Patent ID: 8303978

Claim:
Pendant polymer or oligomer providing monomer according to formula B or C: wherein: A and B are independently —OH, —NH 2 or —CO 2 H; L is —O—, —COO— or —NH—, L′ is L with opposite orientation, and L″ is L; D′ is: together or separately from L′ or L″, a biologically active substance; P is one of (i) —[—X—] p —, wherein 1 or more independently selected repeats X are repeats X′, wherein each repeat X is polyester polymerization compatible with the repeats X′, or (ii) —[—Y—] p —, wherein 1 or more independently selected repeats Y are repeats Y′, wherein each repeat Y is polyester polymerization compatible with the repeats Y′, wherein p is independently an integer from 1 to 20 inclusive; repeats Y′ are: —CH 2 COO— (glycolic acid moiety); —CH(CH 3 )COO— (lactic acid moiety); —CH 2 CH 2 OCH 2 COO— (dioxanone moiety); —CH 2 CH 2 CH 2 CH 2 CH 2 COO— (caprolactone moiety); —(CH 2 ) y COO— where y is one of the numbers 2, 3 or 4, or a number from 6 to 24 inclusive; or —(CH 2 CH 2 O) z CH 2 COO— where z is an integer between 2-24, inclusive; the order and composition of repeats X is selected to provide a desired degradation; repeats Y′ are: —COCH 2 O— (glycolic ester moiety); —COCH(CH 3 )O— (lactic ester moiety); —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety); —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety); —CO(CH 2 ) m O— where m is one of the numbers 2, 3 or 4, or a number from 6 to 24 inclusive; or, —COCH 2 —O—(CH 2 CH 2 O) n — where n is integer between 2-24 inclusive; the order and composition of repeats Y is selected to provide a desired degradation of moiety -L-P—R; and R is according to one of the applicable following options (a) or (b): (a) where P is —[—X—] p , R can be an alkyl group, aryl, alkyl-aryl, an alicyclic group or alkyl-alicyclic, substituted with one or more —O—NO 2 ; and (b) where P is —[—Y—] p , R can be —NO 2 ; P′ is P, and R′ is R; and E is a moiety consisting predominantly of C and H, and optionally including O, S or N; wherein: if L is —COO—, then the corresponding P is —[—X—] p —, and the last repeat X lacks the terminal O and L′ is —O— or —NH—; and if L is —NH—, then the corresponding P is —[—Y—] p —, and the last repeat Y lacks the terminal O and L′ is —O— or —OC(O)—.