Patent ID: 6936590

Claim:
A method for treating diabetes, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, insulin resistance, hyperglycemia, hyperinsulinemia, hyperlipidemia, obesity, hypertriglyceridemia or atherosclerosis via the inhibition of SGLT2 transporters which comprises administering to a mammalian species in need of treatment a therapeutically effective amount of a compound of formula I having the structure wherein R 1 , R 2 and R 2a are independently selected from the group consisting of hydrogen, OH, OR 5 , alkyl, CF 3 , OCHF 2 , OCF 3 , SR 5i or halogen, or two of R 1 , R 2 and R 2a together with the carbons to which they are attached can form an annelated five, six or seven membered carbocycle or heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO 2 ; R 1 and R 4 are each independently selected from the group consisting of hydrogen, OH, OR 5a ,OAryl, OCH 2 Aryl, alkyl, cycloalkyl, CF 3 , —OCHF 2 , —OCF 3 , halogen, —CN, —CO 2 R 5b , —CO 2 H, COR 6b , —CH(OH)R 6c , —CH(OR 5h )R 6d , —CONR 6 R 6a , —NHCOR 5c , —NHSO 2 R 5d , —NHSO 2 Aryl, Aryl, —SR 5e , —SOR 5f , —SO 2 R 5g , —SO 2 Aryl, and a five, six or seven membered heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO 2 , or R 3 and R 4 together with the carbons to which they are attached form an annelated five, six or seven membered carbocycle or heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO 2 ; R 5 , R 5a , R 5b , R 5c , R 5d , R 5e , R 5f , R 5g , R 5h and R 5i are independently alkyl; R 6 , R 6a , R 6b , R 6c , and R 6d are are each independently selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl and cycloalkyl, or R 6 and R 5a together with the nitrogen to which they are attached form an annelated five, six or seven membered heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO 2 ; and A is O or (CH 2 ) n where n is 0-3, or a pharmaceutically acceptable salt, stereoisomer, or prodrug ester thereof.