Patent ID: 7579340

Claim:
A method of treating inflammatory bowel disease in a mammal, said method comprising administering to said mammal an effective amount of a compound of the formula: wherein: R 1 , R 2 , and R 3 are independently selected from the group consisting of hydrogen, halogen, C 1-6 alkyl, aryl, aralkyl, CN, CF 3 , arenesulfonyl, C 1-6 alkanesulfonyl, alkanecarbonyl, CONR 7 R 8 and CO 2 R 9 ; X is NR 19 ; where R 19 is hydrogen; Y is CO; W is selected from the group consisting of H, NR 4 R 5 , alkyl, cycloalkyl, alkoxy, aryloxy, aryl and halogen; T is selected from cyclopentyl, pyrrolidinyl, morpholino, piperidinyl, cyclobutyl, dialkylamino and azetidinyl; R 4 is selected from the group consisting of C 1-6 alkyl, aryl, aralkyl and heterocyclyl; R 5 is selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, aralkyl, arenesulfonyl, C 1-6 alkanesulfonyl, alkanecarbonyl, CONR 7 R 8 , CO 2 R 9 and ZNR 7 R 8 or R 4 and R 5 taken together with the N to which they are attached forms a 4, 5, 6 or 7 membered ring; Z is (CH 2 ) n where n is 0-6; R 6 has formula: wherein: V is thiophene attached to Y at the 2-position; A and G are independently selected from the group consisting of [(CR 18 2 )] m and (NR 17 ) n1 where m is an integer from 0-3 and n1 is an integer from 0-1; B is selected from the group consisting of SO 2 , CO, SO and C(R 18 ) 2 ; and R 17 and each R 18 are independently selected from the group consisting of H, alkyl, cycloalkyl, heterocyclylalkyl, and aryl; R 14 is phenyl, naphthyl, indenyl, indanyl, azulenyl, fluorenyl or anthracenyl; where V, R 14 , R 17 and R 18 may be unsubstituted or substituted with at least one electron donating or electron withdrawing group; R 7 and R 8 are independently selected from the group consisting of hydrogen, lower alkyl, aryl, aralkyl and heterocyclyl or taken together with the N to which they are attached form a pyrrolidine, piperazine, piperidine or morpholine ring; and R 9 is selected from the group consisting of hydrogen, C 1-6 alkyl, aryl and aralkyl; where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 may be unsubstituted or substituted with at least one electron donating or electron withdrawing group; or a pharmaceutically acceptable salt thereof.