Patent ID: 7514408

Claim:
A compound capable of inhibiting β-secretase wherein the compound is of formula I: R′-V-X-Y-Z-A-E-F (SEQ ID NO:93) (I) or a variant thereof in which any of V, A, E and F is/are replaced by a conservative substitution, wherein V, A, E and F are valine, alanine, glutamic acid and phenylalanine, respectively; R 1 is chosen from hydrogen, acetyl, t-butoxycarbonyl and carbobenzoyl; X is chosen from methionine, phenylglycine, n-leucine (n-Leu), asparagine, phenylalanine, glycine and valine; Z is chosen from valine, α-aminobutyric acid (Abu), phenylglycine (Phg) and alanine; and Y is statine, acha (cyclohexylmethylstatine) or phenylstatine (Phe-sta) wherein the phenyl group of phenylstatine optionally has mono or di-substitution chosen from the group consisting of Cl, F, Br, methyl and methoxy.