Patent ID: 8343501

Claim:
An antibody-like protein dimer comprising (a) a tenth fibronectin type III domain ( 10 Fn3) that binds insulin-like growth factor 1 receptor (IGF-IR) with a K D of less than 500 nM covalently or non-covalently linked to (b) a 10 Fn3 that binds epidermal growth factor receptor (EGFR) with a K D of less than 500 nM; wherein the IGF-IR binding 10 Fn3 comprises a BC loop having the amino acid sequence set forth in amino acids 21-30 of SEQ ID NO: 3, a DE loop having the amino acid sequence set forth in amino acids 51-56 of SEQ ID NO: 3, and an FG loop having the amino acid sequence set forth in amino acids 76-83 of SEQ ID NO: 3, and wherein the EGFR binding 10 Fn3 comprises a BC loop having the amino acid sequence set forth in amino acids 21-30 of SEQ ID NO: 112, a DE loop having the amino acid sequence set forth in amino acids 51-56 of SEQ ID NO: 112, and an FG loop having the amino acid sequence set forth in amino acids 76-92 of SEQ ID NO: 112.