Patent ID: 7125990

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof wherein R 1 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 thioalkyl, cyano, halo, C 3-7 cycloalkyl, —C 1-6 alkylene-C 3-7 cycloalkyl, C 2-6 alkenyl or C 3-6 alkynyl; R 2 is C(D)NR 3 R 4 , D′-D″(R 3 )(R 4 ) or CH 2 NR 3 R 4 D′ is CH 2 or a bond; D″ is C, C—OH or CH wherein said C is attached to R 3 by a single or double bond; said C is attached to R 4 by a single or double bond; provided that C is not attached to both R 3 and R 4 by double bonds; said CH is attached to R 3 and R 4 by single bonds; said C of C—OH is attached to R 3 and R 4 by single bonds; D is O or S; R 3 and R 4 are each independently selected from the group consisting of H, C 1-6 alkyl, C 1-6 haloalkyl, —C 1-6 hydroxyalkyl, —C 1-4 alkylene-O—C 1-4 alkyl, —C 1-3 alkylene-C 1-6 thioalkyl, —C 2-6 alkylidene-(C 1-4 alkoxy) 2 , C 3-7 cycloalkyl, —C 1-6 alkylene-C 3-7 cycloalkyl, C 2-6 alkenyl, C 3-6 alkynyl, —C 1-6 alkylene-CN, —C 1-6 alkylene-heterocyclo and —C 1-6 alkylene-aryl; wherein said aryl of said —C 1-6 alkylene-aryl is optionally substituted with one to three of the same or different substituents selected from the group consisting of fluoro, chloro, bromo, cyano, nitro, C 1-4 alkyl and C 1-3 alkoxy; or R 3 and R 4 together with the nitrogen to which they are attached form a five or six-membered heterocycle, said heterocycle optionally containing one additional heteroatom selected from the group consisting of N, S and O; and said heterocycle optionally substituted with one or more groups selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, aryl, —C 1-4 alkylene-aryl, pyridyl and halogen; wherein said aryl of said —C 1-4 alkylene-aryl is optionally substituted with one to three of the same or different substituents selected from the group consisting of fluoro, chloro, bromo, cyano, nitro and C 1-3 alkoxy; X is C; Y is C; A is wherein X 1 is N and is attached to X; Y 1 is N and is attached to Y; G is wherein Y 2 is CE 1 and is attached to Y 1 ; J is a bond; Z 1 is CE 3 and is attached to Z; wherein E 1 and E 3 together form N—CH═CH—CH═, optionally substituted with halogen, —CN, C 1 –C 4 alkyl, C 3 –C 6 cycloalkyl, substituted or unsubstituted phenyl, hydroxy, C 1 –C 4 alkoxy, SH, C 1 –C 4 thioalkyl, NH 2 , NH(C 1 –C 4 alkyl) or N(C 1 –C 4 alkyl) 2 ; Z is N—V, wherein V is phenyl, 2-pyridyl or 3-pyridyl substituted with two to three of the same or different substituents selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-6 thioalkyl, C 1-4 haloalkyl, halogen, N(C 1 –C 4 alkyl) 2 and CN.