Patent ID: 8067452

Claim:
A compound of formula III: wherein R 1 is OH; O—C 1 -C 6 alkyl; C 1 -C 6 alkyl, said C 1 -C 6 alkyl groups optionally substituted with one to three groups selected independently from hydroxy, halogen, C 1 -C 3 alkoxy, and phenyl; or R 1 is —CH 2 B or —CH 2 CH 2 B, where B is selected from C 3-7 cycloalkyl, C 7 -C 9 bicycloalkyl, pyridyl, piperazinyl, piperidinyl, N-morpholyl, tetrahydrofuryl, and naphthyl; C 3 -C 7 cycloalkyl; C 7 -C 9 bicycloalkyl, where all cycloalkyl, bicycloalkyl, pyridyl, piperazinyl, piperidinyl, N-morpholyl, tetrahydrofuryl, and naphthyl groups are optionally substituted with one to three groups selected independently from hydroxy, halogen, and methyl; or R 1 is (CH 2 ) n -G, where n is 1 or 2 and G is a five- or six-membered ring or a 9-14-membered fused ring system, wherein each ring optionally contains 1-3 heteroatoms selected independently from O, N, and S; wherein each ring is optionally substituted with 1-3 groups selected independently from the following: halogen, hydroxy, cyano, oxo, and C 1 -C 4 alkyl, wherein said C 1 -C 4 alkyl group is optionally substituted with one to three halogen atoms; and wherein each ring optionally contains one or more double bonds; or R 1 is —CH(CH 2 OH)CH 2 D, where D is selected from imidazolyl, indolyl, carboxamido, phenyl, cyclohexyl, —CH 2 SCH 3 , and adamantin-1-yl; R 2 and R 3 vary independently and are selected from the group consisting of hydrogen; halogen; hydroxy; nitro; cyano; C 1 -C 4 alkyl; OC 1 -C 4 alkyl, where the C 1 -C 4 alkyl groups and the C 1 -C 4 alkyl moieties of the OC 1 -C 4 alkyl groups are optionally substituted with one to three fluorine atoms; NR 6 R 7 , (CH 3 ) 2 N; CH 3 OC(O); CH 3 CH 2 OC(O); —C(O)NR 6 R 7 ; or —S(O) 2 NR 6 R 7 , where R 6 and R 7 are, independently, H, CH 3 , or CH 3 CH 2 ; or R 2 and R 3 are attached to adjacent carbons and, together with the ring atoms to which they are attached, form an additional, fused, five- or six-membered ring, optionally containing one heteroatom, which ring may be aromatic or aliphatic; R 4 and R 5 vary independently and are selected from the group consisting of H, F, Cl, Br, CH 3 , or CF 3 ; and salts thereof.