Patent ID: 8242160

Claim:
A method of inhibiting inflammation in a mammal in need of treatment for an NF-κB-mediated inflammatory disease that is responsive to inhibition of ubiquitin E1 comprising: administering to the subject an effective amount of one or more pyrazolidinyl compounds of Formula (I), or a pharmaceutically acceptable salt thereof: wherein, each X is O, Y is NO 2 , n is 1, and Z is halogen or C(O)OR 3 , wherein R 3 is a C 1 -C 12 straight or branched chain alkyl, wherein the NF-κB-mediated inflammatory disease is sepsis, arthritis, inflammatory myocarditis, glomerulonephritis, psoriasis, Lupus, asthma, lung fibrosis, atherosclerosis, autoimmune encephalomyelitis, cystic fibrosis, rheumatoid arthritis, or systemic inflammatory response syndrome.