Patent ID: 8492428

Claim:
A composition comprising a compound according to Formula I: or a pharmaceutically acceptable salt thereof, wherein: T 1 -T 9 have sp 2 hybridization; T 3 is N, and T 1 -T 7 and T 4 -T 9 are C; wherein T 10 is W; each W is selected, independently, from the group consisting of H, NH 2 , OH, halo, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkyl, aryloxy, heteroaryl, heteroalkyl, and heterocyclyl groups having from 1 to 8 C atoms, provided that when W is attached to X 1 , W is not present when X 1 is N; each X 1 is selected, independently, from N and C; X 2 is S, O, or NH; G is selected from H, halo, NH 2 , OH, NHR, NRR, S(R), R(NH 2 ), R, and O(R), wherein each R is independently an alkyl group having from 1 to 6 carbon atoms, when the X 1 to which G is attached is C; or G is not present when the X 1 to which G is attached is N; B is NHW or G when X 1 to which B is attached is C; or not present when X 1 to which B is attached is N; Y is C(═O)NR′OH, CO 2 H, imidazolyl, SO 2 NH 2 , R′SO 2 NH 2 , R′SH, or CONR′NH 2 , wherein R′ is H or an alkyl group having from 1 to 6 carbon atoms; and Z is selected from the group consisting of (CH 2 ) m A, (CH 2 ) m NH(CH 2 ) n A, CO(CH 2 ) m A, CO(CH 2 ) m NH(CH 2 ) n A, SO 2 (CH 2 ) m A, and SO 2 (CH 2 ) m NH(CH 2 ) n A; wherein m and n are, independently, an integer from 2 to 14, inclusive; wherein A is selected from the group consisting of amino, imidazolyl, piperidinyl, piperazinyl, morpholinyl, E1, E2, E3, and E4: wherein W 2 is selected from the group consisting of H, OH, N(R 1 )(R 2 ), wherein R 1 and R 2 are, independently, H or alkyl having from 1 to 6 C atoms; and alkyl having from 1 to 6 C atoms.