Patent ID: 7060284

Claim:
A chimeric peptide for stimulating an immune response to HER-2 protein, wherein said chimeric peptide comprises a HER-2 B cell epitope, a T helper (Th) epitope, and a linker joining said HER-2 B cell epitope to said Th epitope, wherein the sequence of the HER-2 B cell epitope is SEQ ID NO: 6, wherein the Th epitope comprises a sequence selected from the group consisting of: N-S-V-D-D-A-L-I-N-S-T-I-Y-S-Y-F-P-S-V, SEQ. ID. NO: 13; P-G-I-N-G-K-A-I-H-L-V-N-N-Q-S-S-E, SEQ ID NO: 14; Q-Y-I-K-A-N-S-K-F-I-G-I-T-E-L, SEQ ID NO: 15; F-N-N-F-T-V-S-F-W-L-R-V-P-K-V-S-A-S-H-L-E, SEQ ID NO: 16; L-S-E-I-K-G-V-I-V-H-R-L-E-G-V, SEQ ID NO: 17; F-F-L-L-T-R-I-L-T-I-P-Q-S-L-N, SEQ ID NO: 18; and T-C-G-V-G-V-R-V-R-S-R-V-N-A-A-N-K-K-P-E, SEQ ID NO: 19; and wherein the linker consists of from one to fifteen amino acids.