Patent ID: 8481587

Claim:
A compound of general formula 1, or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 1 is hydrogen, an optionally substituted C 1 -C 5 alkyl, an optionally substituted C 1 -C 5 alkylsulfonyl, an optionally substituted C 1 -C 5 arylsulfonyl, an optionally substituted heterocyclylsulfonyl, or an acyl; R 2 is hydrogen, a substituted amino group, an optionally substituted hydroxy group, a substituted mercapto group, a substituted alkylamino group; R 3 is hydrogen, a C 1 -C 3 alkyl; R 4 is hydrogen, halogen, a C 1 -C 3 alkyl, which is optionally substituted by amino group, an optionally substituted phenyl or a heterocyclyl; R 5 is one or more cyclic system substituents selected from carboxyl, alkyloxycarbonyl, possibly substituted aryl, non-annelated heterocyclyl, substituted aminomethyl, cyano group; or R 5 is hydrogen under the condition when R 1 is substituent selected from hydroxy substituted C 1 -C 3 alkyl, an amino substituted C 1 -C 3 alkyl and R 2 , R 3 , R 4 are said, or when R 2 is a substituted amino group, an optionally substituted hydroxy group, a substituted mercapto group, a substituted alkylamino group and R 1 , R 3 , R 4 are said; or R 5 is fluoro or trifluoromethyl under the condition when R 1 is substituent selected from a lower alkyl, a substituted sulfonyl, a hydroxy substituted C 1 -C 3 alkyl, an amino substituted C 1 -C 3 alkyl and R 2 , R 3 , R 4 are said, or when R 2 is a substituted amino group, an optionally substituted hydroxy group, a substituted mercapto group, an optionally substituted alkylamino group and R 1 , R 3 , R 4 are said; R 6 is hydrogen, an optionally substituted C 1 -C 5 alkyl, or an acyl.