Patent ID: 8399462

Claim:
A compound of formula I: wherein X 1 is N, N—R 3 , C—R 3 , or O; X 2 is N, N—R a , or C—R a ; X 3 is N, where only one or two of X 1 , X 2 , and X 3 are N; X 4 , X 5 are each independently C or N; X 6 is N or C—R 1 ; where not more than two of X 4 , X 5 , and X 6 are N; and where the bonds between X 1 and X 2 , X 2 and X 3 , X 3 and X 4 , X 4 and X 5 , X 5 and X 1 , and X 5 and X 6 may each independently be either single, double, or form an aromatic ring, with the proviso that a chemically stable structure results; R is where R 9 is H, halo, or lower alkyl, or R 2 and R 9 together form ═O or a ketal thereof; n is 0, 1, or 2; Each R 1 is independently halo, nitro, —CN, —CH 2 CN, —OH, —NH 2 , —COOH, —OCH 2 C≡N, H, cyano-lower alkyl, —Y 1 R 4 , -(lower alkyl), —Y 1 R 4 , -(lower alkyl-oxy)-Y 1 R 4 , -(lower alkyl-amino)-Y 1 R 4 , -(lower alkyl(lower alkyl)amino)-Y 1 R 4 , -(lower alkyl-sulfanyl)-Y 1 R 4 , -(lower alkyl-oxy-lower alkyl)-Y 1 R 4 , -(lower alkyl-amino-alkyl)-Y 1 R 4 , where lower alkyl may be substituted with one or two hydroxy, or R 1 is where A 1 is CHR c , O, S, S(O), S(O) 2 , or NR c , where R c is H, OH, lower alkyl, lower acyl, SO 2 CH 3 , or benzyloxy-carbonyl, and A 2 is N or C—R d , where R d is H, —CH 3 , or —OH; Y 1 is —O—, —NH—, —N(lower alkyl)-, —S—, —SO—, —SO 2 —, —NHSO 2 —, —N(lower alkyl)SO 2 —, —NHC(O)—, —C(O)NH—, —C(O)O—, —OC(O)NH—, or a bond; R 4 is —CN, —CF 3 , —NH 2 , —NH(lower alkyl), —N(lower alkyl) 2 , lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, acyl, benzyl, heterocyclyl (having one or two N, O, or S), heterocyclyl-lower alkyl, each of which is substituted with 0-1 methylsulfanyl, 0-3 hydroxy and 0-3 halo; R 3 is lower alkyl, lower alkoxy, —SO 2 NH 2 , —SO 2 -lower alkyl, —C(O)-lower alkyl, —C(O)-lower alkoxy, —C(O)NH 2 , —C(O)NH-lower alkyl, cyano, or hydroxy-lower alkyl; R 2 is halo, —OH, —SO 2 NH 2 , —CN, or —Y 2 —R 5 , where Y 2 is —C(O)—, —C(O)NR a —, —SO 2 —, —O—, —N(hydroxy-lower alkyl), —NHC(O)—, or —NHSO 2 —; R 5 is lower alkyl, cycloalkyl, phenyl, heterocyclyl, or heteroaryl, wherein R 5 is optionally substituted with —OH, halo, lower alkyl, hydroxy-lower alkyl, alkoxy-lower alkyl, oxo, cyano, or —NR a R b wherein each R a and R b is independently H or lower alkyl; R 8 is H, lower alkyl, —OR e , —SO 2 NH 2 , —NHSO 2 R e , —COOR e , —SO 2 R e , —NH 2 , —CONR a R e , —NHC(O)R e , —CF 3 , —NO 2 , halo, or —CN, where R e is H, lower alkyl, benzyl, or phenyl; Z is hydrogen, halo, alkyl, or NH 2 ; or a pharmaceutically acceptable salt thereof.