Patent ID: 6936600

Claim:
A compound of the formula I a prodrug thereof or a pharmaceutically acceptable salt of said compound or said prodrug, wherein: R 1 is formyl, acetyl, propionyl, carbamoyl or —C(OH)R 4 R 5 ; R 4 and R 5 are each independently hydrogen, methyl, ethyl or hydroxy-(C 1 -C 3 )alkyl; R 2 is hydrogen, (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy; R 3 is wherein R 27 is hydrogen or (C 1 -C 4 )alkyl; R 28 and R 29 are each independently hydrogen, hydroxy, halo, hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro, (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro, phenyl, pyridyl, pyrimidyl, thienyl, furanyl, thiazolyl, oxazolyl, phenoxy, thiophenoxy, SO 2 NR 30 R 31 , CONR 30 R 31 or NR 30 R 31 ; said thienyl, pyrimidyl, furanyl, thiazolyl and oxazelyl in the definition of R 28 and R 29 are optionally substituted by up to two hydroxy, halo, hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro or (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro; said phenyl, pyridyl, phenoxy and thiophenoxy in the definition of R 28 and R 29 are optionally substituted by up to three hydroxy, halo, hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro or (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro; R 30 and R 31 are each independently hydrogen, (C 1 -C 4 )alkyl, (C 3 -C 7 )cycloalkyl or phenyl, said phenyl is optionally substituted with up to three hydroxy, halo, hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro or (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro; or R 30 and R 31 are taken together with the nitrogen to which they are attached to form indolinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl; said pyrrolidinyl and piperidinyl in the definition of R 30 and R 31 are optionally substituted with up to two hydroxy, amino, hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro or (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro; said indolinyl and piperazinyl in the definition of R 30 and R 31 are optionally substituted with up to three hydroxy, amino, hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxycarbonyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro or (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro; said morpholinyl in the definition of R 30 and R 31 is optionally substituted with up to two substituents independently selected from hydroxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyl optionally substituted with up to five fluoro and (C 1 -C 4 )alkoxy optionally substituted with up to five fluoro.