Patent ID: 8828992

Claim:
A compound of Formula (I): or pharmaceutically acceptable salt thereof, wherein: R is selected from the group consisting of C 4 -C 15 arylalkyl optionally substituted with one or more groups selected from the group consisting of halo, trifluoromethyl, trifluoroalkoxy, —NO 2 , —C(═O)OCH 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenyloxy, benzyloxy, —C(═O)H, —OH, and —CH(═N—OH); C 4 -C 15 heteroarylalkyl optionally substituted with one or more groups selected from the group consisting of halo, —C(═O)OCH 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenyloxy and benzyloxy; and C 1 -C 10 alkyl substituted with one or more groups selected from the group consisting of C 1 -C 3 alkoxy, C 1 -C 3 alkylthio, carbamate, tert-butyl-OC(═O)NH—, —NH 3 + , —NH 2 , —OH, —C(═O)OCH 2 CH 3 , —NHC(═O)NH 2 , trifluoromethylsulfanyl, trifluoromethyl and —CN; Y is —O— or —NR 1 —; R 1 is —H or C 1 -C 3 alkyl; R 2 is halo; A is —O— or —S—; B is —CH═ or —N═; Z is selected from the group consisting of imidazolyl, tetrazolyl, —OC(═O)NR 3 R 4 , —NR 5 R 6 , —NHC(═NH)NH 2 , and —NHC(═O)NH 2 , wherein imidazolyl or tetrazolyl is optionally substituted with one or more groups selected from the group consisting of —OH, carbamate, C 1 -C 4 alkyl, halo, —NO 2 , —NH 2 , —CF 3 , —CN and phenyl; each of R 3 and R 4 is independently selected from the group consisting of —H, C 1 -C 5 alkyl optionally substituted with —NH 2 , —NR 7 R 8 or a heterocyclic ring optionally substituted with C 1 -C 3 alkyl, or R 3 and R 4 are taken together to form a 5- or 7-membered heterocyclic ring optionally substituted with C 1 -C 3 alkyl; each of R 5 and R 6 is independently selected from the group consisting of —H, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl and C 1 -C 7 alkyl substituted with one or more groups selected from the group consisting of —OH, —C(═O)NH 2 , C 1 -C 3 alkoxy and carbamate, wherein at least one of R 5 and R 6 is other than —H; each of R 7 and R 8 is independently selected from the group consisting of —H and C 1 -C 3 alkyl; m is 0, 1, 2, 3 or 4; and n is 0, 1, 2, 3, 4 or 5.