Patent ID: 8703907

Claim:
A dendrimer coupled to a multiplicity of substituents of the formula at least one or both R 1 and R 2 is independently CN; NO 2 ; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted alkenyl; optionally substituted alkynyl; COR 3 or SOR 3 or SO 2 R 3 wherein R 3 is H or optionally substituted alkyl; aryl or arylalkyl, each optionally substituted; heteroaryl or heteroarylalkyl, each optionally substituted; or OR or NR 2 wherein each R is independently H or optionally substituted alkyl; SR 4 wherein R 4 is optionally substituted alkyl; aryl or arylalkyl, each optionally substituted; or heteroaryl or heteroarylalkyl, each optionally substituted; wherein R 1 and R 2 may be joined to form a 3-8 member ring; and wherein one and only one of R 1 and R 2 may be H or may be alkyl, arylalkyl or heteroarylalkyl, each optionally substituted; each R 5 is independently H or is alkyl, alkenylalkyl, alkynylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, each optionally substituted; D is a residue of a drug or prodrug coupled through O, S, or N; Y is absent and X is O or S; or Y is NBCH 2 and X is O; wherein B is alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, each optionally substituted; and wherein said coupling to the dendrimer is through any of R 1 , R 2 , R 5 or B.