Patent ID: 7959917

Claim:
An isolated antibody molecule specific for human immunoglobulin E, the antibody molecule comprising a set of CDRs: HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 in which: HCDR1 comprises the amino acid sequence of SEQ. ID. NO: 103; HCDR2 comprises the amino acid sequence of SEQ. ID. NO: 104; HCDR3 comprises the amino acid sequence of SEQ. ID. NO: 105; wherein SEQ. ID. NO: 105 may comprise one or more of the following substitutions: M at position 2 is substituted for L, S, or T; G at position 3 is substituted for L or H; K at position 4 is substituted for R; W at position 5 is substituted for D, S, A, R, or T; and I at position 6 is substituted for A or L; LCDR1 comprises the amino acid sequence of SEQ. ID. NO: 108; LCDR2 comprises the amino acid sequence of SEQ. ID. NO: 109; LCDR3 comprises the amino acid sequence of SEQ. ID. NO: 110, wherein SEQ. ID. NO: 110 may comprise one or more of the following substitutions: P at position 6 is substituted for T, S, N, S, R, H, Q, D, A, or E; T at position 7 is substituted for L, K, S, I, G, H, M, F, R, Q, or N, L at position is 8 substituted for S, H, D, G, R, N, or G; T at position 9 is substituted for H, S, Y, H, L, N, or G, S at position 10 is substituted for G or A, and P at position 11 is substituted for S, L, or G.