Patent ID: 8063075

Claim:
A compound of formula I wherein R 1 is hydrogen or lower alkyl; each R 2 is independently halogen, CN, lower alkyl, or lower alkyl substituted by halogen; Ar is aryl or heteroaryl; R′ is hydrogen, lower alkyl, halogen, cyano or lower alkyl substituted by halogen; R 3 is hydrogen, lower alkyl or hydroxy; X is —CH(R 4 )—, —N(R 4′ )— or —O—; R 4 is hydrogen, hydroxy, ═O, lower alkyl, lower alkynyl, —S(O) 2 -lower alkyl, —C(O)-lower alkyl, —C(O)CH 2 O-lower alkyl, —CH 2 CN, —C(O)CH 2 CN, —C(O)-cycloalkyl wherein the cycloalkyl group is optionally substituted by cyano, lower alkyl, one or two halogen atoms, ═O or amino, or is —C(O)O-lower alkyl, —NH-lower alkyl, —NRC(O)O-lower alkyl, —NRC(O)-lower alkyl or —CH 2 O-lower alkyl; R 4′ is hydrogen, lower alkyl, —S(O) 2 -lower alkyl, —C(O)-lower alkyl, —C(O)CH 2 —O-lower alkyl, —CH 2 CN, —C(O)CN, —C(O)CH 2 CN, —C(O)-cycloalkyl wherein the cycloalkyl group is optionally substituted by cyano, lower alkyl, one or two halogen atoms, ═O or amino, or is —C(O)O-lower alkyl or —CH 2 O-lower alkyl; R is hydrogen or lower alkyl; or R 3 and R 4 together with the carbon atoms to which they are attached form a five or six-membered non aromatic ring or R 3 and R 4′ together with the nitrogen and carbon atoms to which they are attached form a five or six-membered non aromatic ring; n is 0 or 1; m is 0, 1, or 2 when n is 0; or m is 0 or 1 when n is 1; and o is 0, 1, 2 or 3; or a pharmaceutically active salt, racemic mixture, enantiomer, optical isomer or tautomeric form thereof.