Patent ID: RE43343

Claim:
An inhibitor of histone deacetylase represented by the formula Cy—L 1 —Ar—Y 1 —C(O)—NH—Z wherein Cy is cycloalkyl, or heterocyclyl, any of which may be optionally substituted; L 1 is —(CH 2 ) m —W—, where m is 0, 1, 2, 3, or 4, and W is selected from the group consisting of —C(O)NH—, —S(O) 2 NH—, —NHC(O)—, —NHS(O) 2 —, and —NH—C(O)—NH—; Ar is arylene or heteroarylene , wherein said arylene optionally may be additionally substituted and optionally may be fused to an aryl or heteroaryl ring, or to a saturated or partially unsaturated cycloalkyl or heterocyclic ring, any of which may be optionally substituted; Y 1 is a chemical bond or a straight- or branched-chain saturated alkylene, wherein said alkylene may be optionally substituted; and Z is selected from the group consisting of anilinyl, pyridyl, thiadiazolyl, and —O—M, M being H or a pharmaceutically acceptable cation , wherein said thiadiazolyl may be optionally substituted with a substituent selected from the group consisting of thiol, trifluoromethyl, amino and sulfonamido ; provided that when L 1 is —C(O)NH—, Y 1 is an alklene alkylene of the formula —(CH 2 ) n —, n being 1, 2 or 3, and Z is —O—M, then Cy is not aminophenyl, dimethylaminophenyl, or hydroxyphenyl; and further provided that when L 1 is —C(O)NH— and Z is pyridyl, then Cy is not substituted indolinyl.