Patent ID: 7828996

Claim:
A method for forming particles of a material comprising: adding an organic solution comprising a material and an organic solvent to an aqueous solution comprising an emulsifier and water in about 3 minutes to about 60 minutes wherein the ratio (volume:volume) of organic solution to aqueous solution is about 1:3 to about 1:500; and sonicating the aqueous solution during the addition of the organic solution; wherein the material has an aqueous solubility of 50 mg/ml or less, and the organic solvent has an aqueous solubility of 50 mg/ml or less; wherein the sonication apparatus is at least partially submersed in the aqueous solution but does not touch any part of the apparatus used in the addition of the organic solution to the aqueous solution; and wherein the point of addition of the organic solution to the aqueous solution is within the wave funnel produced by the sonication and within a selected distance from the wave source depending on the desired particle size.