Patent ID: 7319163

Claim:
A pharmaceutical composition comprising an effective amount of a compound according to the following formula: wherein: R 1 is selected from: C 5-10 aryl; C 5-10 heteroaryl; and C 5-10 cycloalkyl, said aryl, heteroaryl, and cycloalkyl optionally being substituted with 1 to 3 groups of R a ; R 2 is selected from C 1-4 alkyl; C 2-4 alkenyl; C 2-4 alkynyl; and C 1-4 alkoxy; R 1 may be linked through the available carbons to R 2 , thus forming a C 4 -C 8 cycloalkyl, saturated or partially unsaturated, and optionally substituted with 1 to 3 groups of R a ; X is selected from —O—; —S—; —SO—; SO 2 —; —Se—; —Te—; —N(R c )—; and —S—S—; R 3 and R 4 are the same or different and are selected from —Cl; —Br; C 1-4 alkyl; C 3-7 cycloalkyl; C 2-4 alkenyl; C 2-4 alkynyl; C 1-4 alkoxy; —CF 3 ; —OCF 3 ; —OCF 2 H; —SCH 3 ; —SCF 3 ; —COOH; with the proviso that when R 3 is C 1-4 alkoxy; —OCF 3 ; —OCF 2 H; —SCH 3 ; —SCF 3 ; —COOH, then R 4 must be selected from the group consisting of —Cl, —Br; C 1-4 alkyl; C 2-4 alkenyl, C 2-4 alkenyl, C 3-7 cycloalkyl and —CF 3 ; R 5 is independently selected from: carboxylic acid (—CO 2 H); phosphonic acid (—PO(OH) 2 ); phosphamic acid (—PO(OH)NH 2 ); sulfonic acid (—SO 2 OH); α-keto carboxylic acid (—COCO 2 H); hydroxamic acid (—CONHOH); sulfonamide (—SO 2 NHR′); sulfonamide (—NHSO 2 R′); acylsulfonamide (—CONHSO 2 R′) or (—SO 2 NHCOR′); wherein R′ is selected from the group consisting of phenyl, m-nitrophenyl, p-nitrophenyl, and methyl; R 6 and R 7 are the same or different and are selected from hydrogen; halogen; —CF 3 ; C 1-4 alkyl; C 2-4 alkenyl; C 2-4 alkynyl; C 1-4 alkoxy; and —(CH 2 ) m OH; where m is an integer between 1 and 4; R a is selected from hydrogen; halogen, C 1-4 alkoxy; —Sme; —CN; —NO 2 ; and —N(C 0-4 ) 2 ; R c is selected from hydrogen; C 1-4 alkyl; C 3-4 alkenyl; C 3-4 alkynyl; or pharmaceutically acceptable salts thereof; included for the variables above are all the possible stereoisomers thereof; prodrug ester forms thereof; and radioactive forms thereof; together with a pharmaceutically acceptable carrier.