Patent ID: 7897328

Claim:
A method for removing anti-blood group antigen reactive antibodies in serum, said method comprising: a) providing a collection of microbeads of different subtypes, wherein each subtype is coated with a different blood group antigen including: A type 1 GalNAcα1,3(Fucα1,2)Galβ1,3GlcNAcβ1-R, A type 2 GalNAcα1,3(Fucα1,2)Galβ1,4GlcNAcβ1-R, A type 3 GalNAcα1,3(Fucα1,2)Galβ1,3GalNAcβ1-R, A type 4 GalNAcα1,3(Fucα1,2)Galβ1,3GalNAcβ1-R, B type 1 Galα1,3(Fucα1,2)Galβ1,3GlcNAcβ1-R, B type 2 Galα1,3(Fucα1,2)Galβ1,4GlcNAcβ1-R, B type 3 Galα1,3(Fucα1,2)Galβ1,3GalNAcα1-R, and B type 4 Galα1,3(Fucα1,2)Galβ1,3GlcNAcβ1-R, wherein R represents a point suitable for attachment to said microbeads; b) contacting said serum with said collection of said blood group antigen coated microbeads; c) incubating said serum and said blood group antigen coated microbeads for sufficient time for anti-blood group antigen reactive antibodies in said serum to bind to said blood group antigens; d) separating said microbeads having anti-blood group reactive antibodies bound thereto from said serum thereby removing said reactive anti-blood group antibodies from said serum.