Patent ID: 8877913

Claim:
A DNA encoding a monoclonal antibody or antibody fragment thereof, wherein said monoclonal antibody or antibody fragment thereof comprises a heavy chain variable region (VH) and a light chain variable region (VL), and wherein said monoclonal antibody or antibody fragment thereof is selected from the group consisting of (a)-(d): (a) a monoclonal antibody or antibody fragment thereof in which the VH and VL comprise the amino acid sequences of SEQ ID NOs: 16 and 26, respectively, or the VH and VL comprise the amino acid sequences of SEQ ID NOs: 12 and 22, respectively; (b) a monoclonal antibody or antibody fragment thereof in which CDRs 1 to 3 of the VH comprise the amino acid sequences of SEQ ID NOs: 51 to 53, respectively, and CDRs 1 to 3 of the VL comprise the amino acid sequences of SEQ ID NOs: 54 to 56, respectively; (c) a monoclonal antibody or antibody fragment thereof in which CDRs 1 to 3 of the VH comprise the amino acid sequences of SEQ ID NOs: 27 to 29, respectively, and CDRs 1 to 3 of the VL comprise the amino acid sequences of SEQ ID NOs: 30 to32, respectively; and (d) a monoclonal antibody or antibody fragment thereof selected from the group consisting of (1)-(5): (1) a humanized antibody in which the VH and VL comprise the amino acid sequences of SEQ ID NOs: 77 and 78, respectively; (2) a humanized antibody in which the VH and VL comprise the amino acid sequences of SEQ ID NOs: 96 and 78, respectively; (3) a humanized antibody in which the VH and VL comprise the amino acid sequences of SEQ ID NOs: 98 and 78, respectively; (4) a humanized antibody in which the VH and VL comprise the amino acid sequences of SEQ ID NOs: 100 and 78, respectively; and (5) a humanized antibody in which the VH and VL comprise the amino acid sequences of SEQ ID NOs: 100 and 102, respectively.