Patent ID: 7202238

Claim:
Compounds of the formula (1): wherein: R 1 represents phenyl, 2-indolyl, 3-indolyl, 3-indazolyl or benzo[b]thiophen-3-yl, which groups may be substituted with halogen or alkyl (1–3C), R 2 and R 3 independently represent halogen, H, OCH 3 , CH 3 or CF 3 , R 4 , R 5 and R 6 independently represent H, OH, O-alkyl(1–4C), CH 2 OH, NH 2 , dialkyl(1–3C)N, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or morpholin-4-yl substituted with one or two methyl or methoxymethyl groups, morpholin-4-ylamino, morpholin-4-ylmethyl, imidazol-1-yl, thiomorpholin-4-yl, 1,1-dioxothiomorpholin-4-yl or 3-oxa-8-azabicyclo[3.2.1]oct-8-yl; or R 4 and R 5 together represent a keto, a 1,3-dioxan-2-yl or a 1,3-dioxolan-2-yl group, X represents either O or S, n has the value of 1, 2 or 3, a is the asymmetrical carbon atom 8a, 9a or 10a when n equals 1, 2 or 3 respectively, pharmacologically acceptable salts thereof, and including all possible stereo-isomers in which the substituents on the asymmetrical carbon atoms 3 and ‘a’, as well as on the potentially asymmetrical carbon atoms 6 and 7, are in either the R-configuration or the S-configuration, as well as esters thereof.