Patent ID: 8835684

Claim:
A process for preparing a compound having the following general formula: said process comprising: (a) combining a halomethyl alcohol (HMA) and an amine in a halogenated solvent with aqueous bicarbonate to form a reaction mixture, and heating said reaction mixture to a temperature ranging from about 10° C. to about 50° C., wherein said HMA has the following general formula: (b) adding to said first reaction mixture nosyl chloride while stirring said reaction mixture, and recovering the organic layer of said reaction mixture to form a solution; and (c) reacting said solution with an acid having a pK a of less than about 4 until the reaction is complete, thereby forming the compound of Formula III; wherein: R 1 is an amino acid side chain or a functionalized amino acid side chain; R 2 is a protecting group; R 3 is a member selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and —NHP, wherein P is selected from the group consisting of H, alkyl, cycloalkyl, aryl and a protecting group; X − is the conjugate base of said acid; and L is a leaving group.