Patent ID: 8017585

Claim:
A peptide according to formula (I) or a salt thereof: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 A1-A2-A3-Cys-Tyr-A4-A5-A6-A7-A8-A9-A10-Cys-A11 (I) wherein: A1 is an arginine, lysine, ornithine, citrulline, alanine or glutamic acid residue which optionally is derivatized at the N-terminus by a group selected from the group consisting of a formyl group, an acyl group, a propionyl group, a butyryl group, a pentanoyl group, a C 2-6 alkanoyl group, a benzoyl group, an arylcarbonyl group, a succinyl group, a glutaryl group, a nicotinyl group, an isonicotinyl group, an alkylsulfonyl group and an arylsulfonyl group, or A1 is deleted; A2 represents an arginine or glutamic acid residue if A1 is an arginine, lysine, ornithine, citrulline, alanine or glutamic acid residue which optionally is derivatized at the N-terminus by a group selected from the group consisting of a formyl group, an acyl group, a propionyl group, a butyryl group, a pentanoyl group, a C 2-6 alkanoyl group, a benzoyl group, an arylcarbonyl group, a succinyl group, a glutaryl group, a nicotinyl group, an isonicotinyl group, an alkylsulfonyl group and an arylsulfonyl group, or A2 represents an arginine or glutamic acid residue which optionally is derivatized at the N-terminus by a group selected from the group consisting of a formyl group, an acyl group, a propionyl group, a butyryl group, a pentanoyl group, a C 2-6 alkanoyl group, a benzoyl group, an arylcarbonyl group, a succinyl group, a glutaryl group, a nicotinyl group, an isonicotinyl group, an alkylsulfonyl group and an arylsulfonyl group if A1 is deleted; A3 represents an aromatic amino acid residue; A4 and A5 each independently represents an arginine, lysine, ornithine, citrulline, alanine or glutamic acid residue; A6 represents a D glutamic acid residue; A7 represents a proline residue; A8 represents a tyrosine residue; A9 represents an arginine residue; A10 represents a citrulline residue; A11 represents an arginine residue which optionally is derivatized at the C-terminus by a group selected from the group consisting of —NH 2 , —NHR, —NRR′ and —COOR, wherein R and R′ are selected from the group consisting of C 1-6 alkyl, C 3-8 cycloalkyl, C 6-12 aryl, C 7-14 aralkyl and pivaloyloxymethyl; wherein the cysteines at positions 4 and 13 are optionally disulfide bonded, and wherein any of the amino acids at positions 1-7 and 9-14 in formula (I) is either an L or a D amino acid.