Patent ID: 6933300

Claim:
A method for inhibiting JAK-3 tyrosine kinase activity comprising contacting JAK-3 tyrosine kinase with a compound of formula: wherein X is HN, R 11 N, S, O, CH 2 , or R 11 CH; R 11 is (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkanoyl; R 1 -R 8 are each independently hydrogen, hydroxy, mercapto, amino, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkylthio, or halo; R 9 -R 10 are each independently hydrogen, (C 1 -C 4 )alkyl, (C 1 C 4 )alkoxy, (C 1 -C 4 )alkanoyl or halo; or R 9 and R 10 together are methylenedioxy; or a pharmaceutically acceptable salt thereof; wherein two adjacent groups of R 1 -R 5 together with the phenyl ring to which they are attached may optionally form a fused ring; and wherein the ring formed by the two adjacent groups of R 1 -R 5 may optionally each be independently hydroxy, mercapto, amino, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkylthio, or halo.