Patent ID: 8637575

Claim:
A compound represented by the structure of formula 1: wherein R 1 , R 2 , R 5 and R 6 are each independently selected from H, C 1 -C 4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 4 alkyl-C 2 -C 6 alkenyl, C 1 -C 4 alkyl-C 2 -C 6 alkynyl, (CH 2 CH 2 O) n H, C 3 -C 7 cycloalkyl, aryl, heterocyclyl, heteroaryl, (C 1 -C 4 )-alkylaryl, (C 1 -C 4 )-alkylheterocyclyl, (C 1 -C 4 )-alkylheteroaryl, haloalkyl, acyl and a functional group that gives rise to hydroxyl upon hydrolysis; R 3 , R 4 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 are each independently selected from H, C 1 -C 4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 4 alkyl-C 2 -C 6 alkenyl, C 1 -C 4 alkyl-C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, aryl, heterocyclyl, heteroaryl, (C 1 -C 4 )-alkylaryl, (C 1 -C 4 )-alkylheterocyclyl; (C 1 -C 4 )-alkylheteroaryl, halogen, haloalkyl, NO 2 , CN, N 3 , SO 2 R a , COOR a , CSNR a R b , CSOR a , OR a , CONR a R b , NR a R b , SR a , and CH 2 SR a , wherein R a and R b are each independently H, C 1 -C 4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 4 alkyl-C 2 -C 6 alkenyl, C 1 -C 4 alkyl-C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, aryl, heterocyclyl, heteroaryl, (C 1 -C 4 )-alkylaryl, (C 1 -C 4 )-alkylheterocyclyl, (C 1 -C 4 )-alkylheteroaryl, haloalkyl, (CH 2 CH 2 O) n H, acyl or a functional group that gives rise to hydroxyl upon hydrolysis; and R 15 is H, C 1 -C 4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 4 alkyl-C 2 -C 6 alkenyl, C 1 -C 4 alkyl-C 2 -C 6 alkynyl, haloalkyl, or OR b wherein R b is independently H or C 1 -C 4 alkyl; provided that when R 1 , R 2 , R 5 and R 6 are H, C 1 -C 4 alkyl, acyl or a functional group that gives rise to hydroxyl upon hydrolysis; R 3 and R 7 are H, halogen, haloalkyl or OR c wherein R c is H, C 1 -C 4 alkyl, acyl or a functional group that gives rise to hydroxyl upon hydrolysis; and R 4 is H or CN; then at least one of R 8 -R 15 is not H, including salts, hydrates, solvates, polymorphs, optical isomers, geometrical isomers, enantiomers, diastereomers, and mixtures thereof.