Patent ID: 8680152

Claim:
A method of reducing metastatic cancer bone pain; said method comprising administration to a subject in need thereof a therapeutically effective amount of a cathepsin S/K inhibitor, a cathepsin S/K/B inhibitor, a cathepsin S/K/L inhibitor or a S/K/L/B inhibitor, wherein the inhibitor is a compound of Formula (I): where: R 1 is hydrogen or alkyl; R 2 is cycloalkyl or cycloalkylalkyl optionally substituted with one or two substituents independently selected from alkyl, alkoxy or halo; R 3 is hydrogen or alkyl; R 4 is hydrogen, alakyl, or cycloalkyalkyl; R 5 is haloalkyl, (alkylene or haloalkylene)-X—R 9 (where X is a bond, —O—, —S—, —SO—, —SO 2 —, or —NHSO 2 — and R 9 is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, pyrimidinyl, pyridinylalkyl, phenyl or phenylalkyl) wherein the alicyclic, pyridinyl, or phenyl ring in R 5 is optionally substituted with one, two, or three R a independently selected from alkyl, haloalkyl, alkoxy, hydroxy, halo, or haloalkoxy or optionally substituted with one or two R b independently selected from hydrogen, alkyl, haloalkyl, alkoxy, hydroxy, haloalkoxy, halo, and one R c selected from or —SO 2 R 11 (where R 11 is alkyl); R 6 is hydrogen or haloalkyl; R 7 is hydrogen, alkyl, or haloalkyl; and R 8 is phenyl or phenoxy-CF 2 — wherein the phenyl or phenoxy is optionally substituted with one, two, or three R e independently selected from alkyl, halo, haloalkyl, hydroxy, alkoxy, and haloalkoxy; or a pharmaceutically acceptable salt thereof.