Patent ID: 7893208

Claim:
A mutein of human tear lipocalin, wherein the mutein comprises at least 12-16 amino acid mutations with respect to the wild type amino acid sequence of mature human tear lipocalin, wherein said mutations are selected from any of the amino acids 25, 26, 27, 28, 29, 30, 31, 32, 33, 56, 57, 58, 83, 105, 106, 108 and 109 of the linear polypeptide sequence of the mature wild-type form of human tear lipocalin set forth in SEQ ID NO: 58, and wherein the mutein binds a given non-natural target of human tear lipocalin with detectable affinity, wherein said mutein possesses at least 70% sequence identity with SEQ ID NO: 58, wherein sequence identity means the percentage of pair-wise identical residues, following homology alignment of a sequence of a polypeptide with a sequence in question, with respect to the number of residues in the longer of these two sequences.