Patent ID: 7915012

Claim:
A method for screening a TRPV2 (transient receptor potential vanilloid 2) blocker comprising the following steps: 1) treating TRPV2 positive neurons with probenecid and TRPV2 blocker candidates; 2) treating TRPV2 negative neurons with the TRPV2 blocker candidates of step 1) and a non-specific TRPV2 activator; 3) measuring TRPV2 activities of both TRPV2 positive neurons treated in step 1) and TRPV2 negative neurons treated in step 2); and 4) selecting candidates which inhibit TRPV2 activity of TRPV2 positive neurons treated with probenecid and TRPV2 blocker candidates but do not affect the TRPV2 activities of TRPV2 negative neurons treated with the TRPV2 blocker candidates and the non-specific TRPV2 activator by comparing the TRPV2 activities of step 3) with that of TRPV2 positive neurons treated with probenecid alone.