Patent ID: 8309562

Claim:
A compound represented by Formula VIb: or pharmaceutically acceptable salt thereof, wherein: R 1 is methyl or ethyl; R 5 is H or F; and R 2 is: (i) cyano-C 1-6 alkyl, or tetrazolyl; (ii) C 1-6 alkoxy substituted with either C 1-6 alkoxy or amino; or (iii) —N(R a )(R b ) or —N(R a )( R b )—C 1-6 alkyl-, wherein R a is C 1-6 alkoxy, halo-C 1-6 alkyl, —C(═O)—C 1-6 alkyl (substituted with —C(═O)OH or amino), —C(═O)—pyridinyl, or —C 1-6 alkyl-C(═O)O—C 1-6 alkyl and R b is H or C 1-6 alkyl, or R a and R b together with the nitrogen atom to which they are both linked form either (a) a bicyclic heterocycle substituted with at least one oxo group or (b) piperidinyl or pyrrolidinyl substituted with at least one oxo group; R 3 , R 4 , and R 6 -R 11 are independently H, halo, N 3 , OH, thiol, nitro, CN, NH 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthiol, halo-C 1-6 alkyl, C 2-6 alkenyl-O—, C 2-6 alkynyl-O—, hydroxy-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 acyl, C 1-6 acyloxy, —C 1-6 alkyl-C(O)O—C 1-6 alkyl, —C(O)O—C 1-6 alkyl, C 1-6 alkyl-C(O)O—C 1-6 alkyl-, C 1-6 acylamido, —N(R a )(R b ), —C 1-6 alkyl-C(O)N(R a )(R b ), —C(O)N(R a )(R b ), N(R a )(R b )—C 1-6 alkyl-, 3, 4, 5, or 6-membered carbocycle, heterocycle, aryl, or heteroaryl, wherein R a and R b are independently H, OH (R a and R b are not both OH), C 2-6 hydroxyalkyl, or C 1-6 alkyl, or R a and R b together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle; wherein any of the groups is optionally substituted with 1-3 substituents wherein each substituent is independently halo, N 3 , OH, thiol, nitro, CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthiol, C 2-6 alkenyl-O—, C 2-6 alkynyl-O—, hydroxy-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 acyl, C 1-6 acyloxy, C 1-6 alkyl-C(O)O—C 1-6 alkyl-, C 1-6 alkyl-OC(O)—C 1-6 alkyl-, C 1-6 acylamido, —N(R a )(R b ), —C 1-6 alkyl-C(O)N(Ra)(Rb), —C(O)N(R a )(R b ), N(R a )(R b )—C 1-6 alkyl-, wherein R a and R b are independently H, OH (R a and R b are not both OH), C 2-6 hydroxyalkyl, or C 1-6 alkyl or R a and R b together with the nitrogen atom to which they are both linked form a 3, 4, 5 or 6-membered heterocycle, wherein optionally any two adjacent R 7 R 11 groups together form a 3, 4, 5 or 6-membered carbocycle or heterocycle; provided that R 9 is not —O(C 1-6 alkyl)C(O)O(C 1-6 alkyl), and when R 9 is H, then R 8 and R 10 are not both H, or one H and the other halo.