Patent ID: 7858116

Claim:
A hepatocyte-targeting composition comprising: free recombinant human insulin isophane, at least one free non-humulin insulin, recombinant human insulin isophane associated with a water insoluble target molecule complex, and at least one non-humulin insulin associated with a water-insoluble target molecule complex; wherein said target molecule complex is comprised of a combination of a supra-molecular lipid construct matrix comprising at least one lipid component, and multiple linked individual units, each of said individual units comprising at least one bridging component selected from the group consisting of a transition element, an inner transition element, and a neighbor element of said transition element; and a complexing component; wherein said complexing component comprises at least one member selected from the group consisting of: N-(2,6-diisopropylphenylcarbamoylmethyl) iminodiacetic acid; N-(2,6-diethylphenylcarbamoylmethyl) iminodiacetic acid; N-(2,6-dimethylphenylcarbamoylmethyl) iminodiacetic acid; N-(4-isopropylphenylcarbamoylmethyl) iminodiacetic acid; N-(4-butylphenylcarbamoylmethyl) iminodiacetic acid; N-(2,3-dimethylphenylcarbamoylmethyl) iminodiacetic acid; N-(2,4-dimethylphenylcarbamoylmethyl) iminodiacetic acid; N-(2,5-dimethylphenylcarbamoylmethyl) iminodiacetic acid; N-(3,4-dimethylphenylcarbamoylmethyl) iminodiacetic acid; N-(3,5-dimethylphenylcarbamoylmethyl) iminodiacetic acid; N-(3-butylphenylcarbamoylmethyl) iminodiacetic acid; N-(2-butylphenylcarbamoylmethyl) iminodiacetic acid; N-(4-tertiary butylphenylcarbamoylmethyl) iminodiacetic acid; N-(3-butoxyphenylcarbamoylmethyl) iminodiacetic acid; N-(2-hexyloxyphenylcarbamoylmethyl) iminodiacetic acid; N-(4-hexyloxyphenylcarbamoylmethyl) iminodiacetic acid; aminopyrrol iminodiacetic acid; N-(3-bromo-2,4,6-trimethylphenylcarbamoylmethyl) iminodiacetic acid; benzimidazole methyl iminodiacetic acid; N-(3-cyano-4,5-dimethyl-2-pyrrylcarbamoylmethyl) iminodiacetic acid; N-(3-cyano-4-methyl-5-benzyl-2-pyrrylcarbamoylmethyl) iminodiacetic acid; and N-(3-cyano-4-methyl-2-pyrrylcarbamoylmethyl) iminodiacetic acid; provided that when said transition element is chromium, a chromium target molecule complex is created; wherein said target molecule complex further comprises a negative charge.