Patent ID: 7071355

Claim:
A compound of the general formula (I) or a salt or a physiologically functional derivative thereof: wherein A is a non-heterocyclic non-aromatic ring system containing 4 to 8 carbon atoms, wherein the ring system comprises at least one double bond and wherein one or more of the carbon atoms in the ring represented X may optionally be carbonyl (C═O); D is O, S, SO 2 , NR 4 or CH 2 ; z 1 and z 2 are independent from each other O, S, or NR 5 ; R 1 is independently —CO 2 R″, —SO 3 H, —CONR*R″, —CR″O, —SO 2 —NR*R″, —NO 2 , —SO 2 —R″, —SO—R*, —CN, alkoxy, —OH, —SH, alkylthio, —NR″—CO 2 —R′, —NR″—CO—R*, —NR″—SO 2 —R′, —O—CO—R*, —O—CO 2 —R*, —O—CO—NR*R″; cycloalkyl, alkylamino, hydroxyalkylamino, aryl, or heteroaryl; R 9 is independently H, halogen, haloalkyl, haloalkyloxy or alkyl; R* is independently H, alkyl, cycloalkyl, aminoalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R′ is independently H, —CO 2 R″, —CONHR″, —CR″O, —SO 2 NR″, —NR″—CO-haloalkyl, —NO 2 , —NR″—SO 2 -haloalkyl, —NR″—SO 2 -alkyl, —SO 2 -alkyl, —NR″—CO-alkyl, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkyloxy, aryl arylalkyl or heteroaryl; R″ is independently hydrogen, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, heteroaryl or aminoalkyl; R 2 is H, OR 6 , or NHR 7 ; R 3 is H, alkyl, cycloalkyl, aryl, arylalkyl, alkoxy, O-aryl, O-cycloalkyl, halogen, aminoalkyl, alkylamino, hydroxylamino, hydroxylalkyl, haloalkyl, haloalkyloxy, heteroaryl, alkylthio, S-aryl, or S-cycloalkyl; R 4 is H, alkyl, cycloalkyl, aryl, or heteroaryl; R 5 is H, OH, alkoxy, O-aryl, alkyl, or aryl; R 6 is H, alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, alkoxyalkyl, acylmethyl, (acyloxy)alkyl, non-symmetrical (acyloxy)alkyldiester, or dialkylphosphate; R 7 is H, alkyl, aryl, alkoxy, O-aryl, cycloalkyl, or O-cycloalkyl; R 8 is hydrogen or alkyl; E is an alkyl or cycloalkyl group which is substituted by [D m -(CHR 3 ) n ] q Y or a monocyclic or polycyclic substituted or unsubstituted ring system which contains at least one aromatic ring; Y is hydrogen, halogen, haloalkyl, haloalkyloxy, alkyl, cycloalkyl, a monocyclic or polycyclic substituted or unsubstituted ring system and which contains at least one aromatic ring or m is 0 or 1; n is 0 or 1; p is 0 or 1; r is 0 or 1; q is 0 or 1; t is 1 to 3; and v is 0 to 3.