Patent ID: 8114995

Claim:
A method of preparing a compound of Formula I: and solvates, hydrates, tautomers, and pharmaceutically acceptable salts thereof, wherein: R 1 , R 2 , R 3 , and R 4 are each independently selected from alkoxy, alkyl, amido, aryloxy, cycloalkyl, halogen, heterocyclyl, hydrogen, and nitro; R 6 is selected from alkyl, alkoxy, and halogen; R 5 is hydrogen, or R 5 and R 6 may be taken together with the carbon atoms to which they are attached, to form a ring selected from aryl, cycloalkyl, and heterocycyl; R 8 is selected from alkyl, alkoxy, halogen, and hydrogen; W is C and p is 1; comprising a) reacting an aldehyde of Formula II: wherein R 5 , R 6 and R 8 are as defined above, with ethylene carbonate to form a compound of Formula III: b) reacting the compound of Formula III with a compound of Formula IV wherein R 1 , R 2 , R 3 , and R 4 are as defined above, to form the compound of Formula I.