Patent ID: 8901125

Claim:
A compound having a structure represented by a formula: wherein R 1 is aryl or heteroaryl and substituted with 0, 1, 2, or 3 groups each independently selected from cyano, halo, hydroxyl, C1-C4 alkyl, C1-C4 alkyloxy, C1-C4 monohaloalkyl, and C1-C4 polyhaloalkyl; wherein each of R 2a and R 2b is independently selected from hydrogen and C1-C4 alkyl; wherein R 3 is selected from hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 monohaloalkyl, and C1-C4 polyhaloalkyl; wherein each of R 4a and R 4b is selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkyloxy, hydroxy(C1-C4 alkyl), and (C1-C4 alkyloxy)-(C1-C4 alkyl)-; or R 4a and R 4b are covalently bonded and, together with the intermediate carbon, comprise an optionally substituted 3- to 7-membered spirocycloalkyl; wherein each of R 5a and R 5b is selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkyloxy, hydroxy(C1-C4 alkyl), and (C1-C4 alkyloxy)-(C1-C4 alkyl)-; or R 5a and R 5b are covalently bonded and, together with the intermediate carbon, comprise an optionally substituted 3- to 7-membered spirocycloalkyl; wherein R 6 is selected from hydrogen, C1-C8 alkyl, C1-C8 monohaloalkyl, C1-C8 polyhaloalkyl, hydroxy(C1-C8 alkyl), (C1-C6 alkyl)-O—(C1-C6 alkyl)-, (C1-C6 monohaloalkyl)-O—(C1-C6 alkyl)-, (C1-C6 polyhaloalkyl)-O—(C1-C6 alkyl)-, (C1-C6 alkyl)-NH-(C1-C6 alkyl)-, (C1-C6 alkyl)(C1-C6 alkyl)N—(C1-C6 alkyl)-, Cy 1 , Cy 1 -(C2-C6 alkyl)-, and Cy 1 -C(R 8a )(R 8b )—; and wherein Cy 1 , when present, is selected from C3-C8 cycloalkyl, C2-C7 heterocycloalkyl, phenyl, monocyclic heteroaryl, and bicyclic heteroaryl; and wherein Cy 1 , when present, is substituted with 0, 1, 2, or 3 groups each independently selected from halo, cyano, —NH 2 , mono(C1-C6 alkyl)amino, di(C1-C6 alkyl)amino, C1-C4 alkyl, C1-C4 alkyloxy, (C1-C4 alkyloxy)-(C1-4-alkyl)-, (C1-C4 alkyloxy)-(C1-C4 alkyloxy)-, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, (C1-C4 polyhaloalkyl)-(C1-C4 alkyloxy)-, C3-C6 cycloalkyl, C2-C5 heterocycloalkyl, and phenyl; wherein each of R 8a and R 8b , when present, is independently selected from hydrogen, C1-C8 alkyl, C1-C8 monohaloalkyl, C1-C8 polyhaloalkyl, and C1-C8 alkoxy; wherein each of R 7a and R 7b , when present, is selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkyloxy, hydroxy(C1-C4 alkyl), and (C1-C4 alkyloxy)-(C1-C4 alkyl)-; or R 7a and R 7b are covalently bonded and, together with the intermediate carbon, comprise an optionally substituted 3- to 7-membered spirocycloalkyl; or a pharmaceutically acceptable salt thereof.