Patent ID: 7115647

Claim:
A method for inhibiting the growth of neoplastic cells sensitive to the compounds of formula I comprising exposings the cells to a growth inhibiting effective amount of a compound of Formula I: wherein R 1 to R 3 each represent hydrogen, a lower alkyl group, an oxy group, an oxy-lower alkyl group, a lower alkyloxy group, a carbonyl group, a lower alkenyl group, an optionally-substituted imino group, a lower alkylimino group optionally substituted at its nitrogen atom, a thio-lower alkyl group, or a lower alkylthio group, wherein any of said group is optionally substituted by an aryl or a heterocyclic ssubstituent, wherein said substituent optionally is further substituted by any of a halogen atom, a nitro group, a lower alkylamino group, an acylamino group, a lower alkyl group, a lower alkoxy group, a halo-lower alkyl group, a lower cycloalkyl group, or an aryl, heterocyclic, aryl-lower alkyl, heterocyclic-lower alkyl, aryl-lower alkyloxy, heterocyclic-lower alkyloxy, aryl-lower alkenyl or heterocyclic-lower alkenyl group that in turn is optionally substituted by any of a halogen atom or a lower alkyl group, with the proviso that R 1 to R 3 are not simultaneously hydrogen atoms; R 4 is selected from the group consisting of hydrogen atom or lower alkyl; R 5 is selected from the group consisting of carboxyl, an esterified carboxyl group, or an amidated carboxyl group.