Patent ID: 8883162

Claim:
A method of treating a cancer that expresses IGF-1R comprising: a) administering a complex to an individual with the cancer, wherein the complex comprises: (i) an anti-IGF-1R IgG antibody or antigen-binding fragment thereof attached to one or more anchor domain (AD) moieties from an AKAP protein; and (ii) two or more copies of an effector attached to a dimerization and docking domain (DDD) moiety from a human protein kinase A (PKA) regulatory subunit RIα, RIβ, RIIα or RIIβ, wherein the effector is a second antigen-binding antibody fragment or a cytokine; and b) administering a therapeutic agent to the individual; wherein two copies of the DDD moiety form a dimer that binds to the AD moiety to form the complex.