Patent ID: 7803571

Claim:
A method for identifying an IRS protein kinase inhibitor, the method comprising the steps of a) contacting, in the presence of at least one possible inhibitor, PKC-ζ with at least one IRS peptide comprising amino acid sequence of SEQ ID NO:17 comprising at least one PKC-ζ-Ser-phosphorylation site, and b) measuring the phosphorylation of a PKC-ζ-Ser-phosphorylation site at a residue selected from the group consisting of residues 498, 570, and 612, wherein phosphorylation at one or more of residues 498, 570 or 612 inhibits insulin-stimulated tyrosine phosphorylation of the IRS peptide or inhibits interaction of p85α regulatory subunit of phosphatidylinositol 3-kinase with the IRS peptide.