Patent ID: 7465736

Claim:
An azole compound according to formula (I), a tautomer thereof, a geometrical isomer thereof, an optically active form thereof as an enantiomer thereof, a diastereomer thereof, a racemate form thereof, or a pharmaceutically acceptable salt thereof, wherein X is S; A is a pyrimidinyl, which may be substituted with 1, 2 or 3 moieties R 2 and/or fused with an aryl or a heteroaryl group; R 0 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkyl-aryl, aryl, heteroaryl, C 1 -C 6 -alkyl-heteroaryl, —C(O)—OR 5 , —C(O)—R 5 , —C(O)—NR 5 R 5′ , and —(SO 2 )R 5 , wherein R 5 and R 5′ , being independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, C 1 -C 6 -alkyl aryl, and C 1 -C 6 -alkyl heteroaryl; R 1 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxy, C 1 -C 6 -sulfanyl, primary, secondary or tertiary amino groups, aminoacyl, aminocarbonyl, C 1 -C 6 alkoxycarbonyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 heterocycloalkyl, aryl, heteroaryl, carboxyl, cyano, halogen, hydroxy, nitro, sulfonamide and hydrazide; R 2 is selected from the group consisting of hydrogen, sulfonyl, amino, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, and C 2 -C 6 -alkynyl, wherein said alkyl, alkenyl, alkynyl chains may be interrupted by a heteroatom selected from the group consisting of N, O, S, aryl, heteroaryl, saturated or unsaturated 3-8-membered cycloalkyl, and heterocycloalkyl, wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl groups may be fused with 1-2 further cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, an acyl moiety, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkenyl aryl, C 1 -C 6 -alkenyl heteroaryl, C 1 -C 6 -alkynyl aryl, C 1 -C 6 -alkynyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, C 1 -C 6 -alkenyl cycloalkyl, C 1 -C 6 -alkenyl heterocycloalkyl, C 1 -C 6 -alkynyl cycloalkyl, C 1 -C 6 -alkynyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkyl carboxy, C 1 -C 6 -alkyl acyl, aryl acyl, heteroaryl acyl, C 3 -C 8 -(hetero)cycloalkyl acyl, C 1 -C 6 -alkyl acyloxy, C 1 -C 6 -alkyl alkoxy, C 1 -C 6 -alkyl alkoxycarbonyl, C 1 -C 6 -alkyl aminocarbonyl, C 1 -C 6 -alkyl acylamino, acylamino, C 1 -C 6 -alkyl ureido, C 1 -C 6 -alkyl carbamate, C 1 -C 6 -alkyl amino, C 1 -C 6 -alkyl ammonium, C 1 -C 6 -alkyl sulfonyloxy, C 1 -C 6 -alkyl sulfonyl, C 1 -C 6 -alkyl sulfinyl, C 1 -C 6 -alkyl sulfanyl, C 1 -C 6 -alkyl sulfonylamino, C 1 -C 6 -alkyl aminosulfonyl, hydroxy or halogen, wherein the following compounds are excluded: