Patent ID: 7446210

Claim:
A compound having Formula I, wherein X is CF; Z is CH; A and B are independently selected from ethenyl, ethynyl, aryl, heteroaryl, 3-8 numbered carbocycle or 5-8 numbered heterocycle, each of which can be optionally substituted with 1, 2, 3 or 4 R groups; K is selected from a bond, ethenyl, ethynyl, NR′, O, S, SO 2 or CO; Ring P is pyrazole follows: P 4 is substituted or unsubstituted benzene selected from: wherein P 4 is optionally substituted with 1, 2, 3 or 4 R groups; R 1 is selected from hydrogen, halogen, alkyl, haloalkyl, haloalkoxy, alkenyl, alkynyl, cycloalkyl, NCH 2 R, OCH 2 R, SCH 2 R, S(O) p CH 2 R, C(O)NR, OC(O)NR, NR a C(O)NR a CH 2 R, NR a C(O)OCH 2 R, NR a C(O)CH 2 R, hydroxyalkyl, cyano, nitro, trifluoromethyl or-CO 2 R; provided that R 1 forms other than an N-halo, N-N, N-S, N-O, or N-CN bond; R is selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, hydroxy, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cyano, nitro, trifluoromethyl, —CO 2 R x , —CH 2 OR x or —OR x , R X is selected from hydrogen, C 1-6 alkyl; optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl, wherein optionally substituted alkyl, cycloalkyl, aryl and heteroaryl are each optionally substituted with one, two, three or four substituents selected from halogen, hydroxy, amino, mono or dialkyl amino, cyano, nitro, ester, acid or ether; R′ is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted C 6-10 arylalkyl, optionally substituted heteroaryl or optionally substituted heteroaryl-alkyl, wherein optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, C 6-10 aryl, the C 6-10 aryl portion of C 6-10 arylalky, heteroaryl and the heteroaryl portion of heteroaryl-alkyl are each optionally substituted with one, two, three or four substituents selected from halogen. hydroxy, carboxy, amino, monoalkylamino, dialkylamino, cyano, nitro, ester, acid or ether; and R 2 is selected from hydrogen, C 1-4 alkyl or C 6-10 aryl; or a pharmaceutically acceptable salt or stereoisomer thereof.