Patent ID: 7642270

Claim:
A compound of Formula I: or a salt, stereoisomer, tautomer or ester thereof, wherein: W is N or CH; A is absent or alkyl; Y is a ring selected from cycloalkyl, bicycloalkyl, aryl, alkylaryl, cycloalkylaryl, arylcycloalkyl, or heteroaryl provided that Y is not thiazole; R 101 is hydrogen, hydroxyl, methyl, halogen, —CF 3 , or methoxy; R 200 is halogen, alkoxy optionally substituted with —CH(OH)—CH 2 —NR 203 R 204 , alkyl optionally substituted with R 201 , heterocyclyl optionally substituted with one alkyl and optionally substituted with one R 202 , amino, alkylamino, dialkylamino, —C(O)(CH 2 ) n NR 203 R 204 , heteroaryl, or —R 300 —R 400 ; wherein n is 0, 1, 2, 3, or 4; R 201 is hydroxyl, methyl, halogen, —CF 3 , amino, alkyl amino, dialkylamino or methoxy; R 202 is alkyl, —C(O)—CH 3 , —CH 2 —C(O)—CH 3 , —C(O)(CH 2 ) n NR 203 R 204 , or —CON-alkyl-NR 203 R 204 ; wherein n is 0, 1, 2, 3, or 4; R 203 and R 204 are independently hydrogen, alkyl, or R 203 and R 204 may be taken together to form a ring selected from the following: wherein R a , R c and R d are independently hydrogen or alkyl; R 300 is alkyl; R 400 is —NR 403 R 404 , —SO 2 NR 405 R 406 , oxazolidinonyl wherein said oxazolidinonyl is optionally substituted with one or two R 401 , piperazinyl wherein said piperazinyl is optionally substituted with R 202 or pyrrolidinonyl wherein said pyrrolidinonyl is optionally substituted with one or two R 401 ; wherein R 401 is methyl, —C(O)—CH 3 , or —CH 2 —C(O)—CH 3 ; wherein R 403 and R 404 are independently hydrogen, alkyl, or R 403 and R 404 may be taken together to form a ring selected from the following: wherein R a , R c and R d are independently hydrogen or alkyl; R 405 and R 406 are independently hydrogen, alkyl, or R 405 and R 406 may be taken together to form a ring selected from the following: wherein R a , R c and R d are independently hydrogen or alkyl; and Z is CO 2 H, CO 2 alkyl, or CONR 1 R 2 ; wherein R 1 is hydrogen or alkyl; and R 2 is hydrogen, alkyl, cycloalkyl, or alkoxy.