Patent ID: 8410115

Claim:
A method of using an alpha-4 inhibitor compound to treat a patient with an inflammatory, or autoimmune disease comprising: (a) administering a pharmaceutically effective amount of the alpha-4 inhibitor compound; (b) monitoring the patient for at least one indicator of progressive multifocal leukoencephalopathy; and (c) discontinuing administration of the alpha-4 inhibitor compound when at least one indicator of progressive multifocal leukoencephalopathy is present; wherein the monitoring improves safety of treatment; wherein the alpha-4 inhibitor compound is a compound of Formula V, a pharmaceutically acceptable salt or ester of any of the foregoing: wherein: R 1 is selected from the group consisting of C 1 to C 4 alkyl and C 1 to C 4 haloalkyl; and R 2 is selected from the group consisting of C 1 to C 4 alkyl, C 2 to C 4 alkenyl, C 2 to C 4 alkynyl, C 3 -C 6 cycloalkyl and benzyl.