Patent ID: 7883688

Claim:
A supramolecular polycation assembly capable of forming a complex with a nucleic acid for carriage thereof, the supramolecular polycation assembly comprising: at least one amino-substituted cyclodextrin having a cavity extending therethrough, wherein the amino-substituted cyclodextrin comprises one or a plurality of aminated D-glucose units of the formula: wherein: p is an integer from 0 to 8; and T is optional and is an alkyl selected from the group consisting of methyl, ethyl and propyl; a co-polymer backbone threaded into the cavity of the cyclodextrin; and a pair of bulky moieties capping the terminals of the co-polymer backbone to inhibit dethreading of the cyclodextrin from the co-polymer backbone, wherein the net positive charge of the supramolecular polycation assembly enables a complex to form with the nucleic acid.