Patent ID: 8298527

Claim:
A method of expressing a non- Helicobacter pharmacologically active molecule of interest in a mammal, the method comprising: (a) providing a composition comprising a Helicobacter cell comprising a nucleic acid comprising: (i) at least one non- Helicobacter sequence encoding a non- Helicobacter pharmacologically active molecule of interest linked to a secretory signal peptide; and (ii) a regulatory sequence capable of controlling expression of the non- Helicobacter sequence in the Helicobacter cell, wherein the Helicobacter cell is not a DapE mutant strain; and (b) administering to the mammal an effective amount of the composition, wherein the Helicobacter cell chronically colonizes the mucosa of said mammal and the non- Helicobacter sequence encoding a non- Helicobacter pharmacologically active molecule of interest is expressed in the mammal.