Patent ID: 7211595

Claim:
A compound of formula (I) or a therapeutically acceptable salt thereof, wherein E is a six-membered aromatic carbocyclic ring in which F and G are C; L 1 is O; L 2 is selected from the group consisting of a bond, C 2 alkenylene, C 2 alkynylene, O, NR 9 , C(O), S, S(O), SO 2 , SO 2 NR 9 , NR 9 SO 2 , C(O)NR 9 , NR 9 C(O), and CO 2 ; X is NR 7 ; R 1 is selected from the group consisting of aryl and arylalkyl; R 2 is selected from the group consisting of hydrogen, alkoxy, alkyl, amino, aminoalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, halo, haloalkyl, hydroxy, and hydroxyalkyl; R 3 is selected from the group consisting of aryl, heterocycle, and cycloalkyl, wherein the heterocyle may be substituted or unsubstituted and is selected from the group consisting of benzodioxolyl, thiophenyl, quinolinyl, pyridinyl, and dihydropyridinyl; R 4-6 are each independently selected from the group consisting of hydrogen, NR 9 C(O), C(O)NR 9 , alkanoyl, alkenyl, alkoxy, alkoxyalkyl, alkyl, alkylsulfonyl, alkynyl, amido, amino, aminoalkyl, aminosulfonyl, aryl, arylalkyl, aryloxy, arylsulfonyl, azido, carboxy, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, nitro, nitroalkyl, oxo, and thio(oxo); R 7 is selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, and trialkylsilyl; R 9 is selected from the group consisting of hydrogen, alkoxyalkyl, alkyl, amidoalkyl, aminoalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, carboxyalkyl, hydroxyalkyl; and each R 12 is independently selected from the group consisting of hydrogen, alkoxy, alkyl, amino, halo, and hydroxy; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3 or 4; and q is 0, 1, 2, 3 or 4.