Patent ID: 7754189

Claim:
A radiolabeled compound having a structure of the formula: wherein: m and n individually are 1 or 2; p is 1, 2, 3, or 4; X is oxygen or NR′; Y is oxygen or sulfur; Z is NR′, a covalent bond, or a linker species, A; A is selected from the group —CR′R″—, —CR′R″—CR′R″—, —CR′═CR′—, and —C≡C—, provided that when Z is a covalent bond or A, X must be nitrogen; Ar is an unsubstituted or substituted, carbocyclic or 3- to 10-membered heterocyclic, monocyclic or fused polycyclic aryl group; Cy is a pyridinyl; the depicted wavy lines indicate variable stereochemistry; and substituents are selected from the group consisting of alkyl, alkenyl, 3- to 10-membered heterocyclyl, cycloalkyl, 5- or 6-membered carbocyclic or heterocyclic aromatic ring which may include monocyclic or fused polycyclic rings, substituted aryl, arylalkyl wherein the aryl is a 5- or 6-membered carbocyclic or heterocyclic aromatic ring which may include monocyclic or fused polycyclic rings, substituted arylalkyl wherein the aryl is a 5- or 6-membered carbocyclic or heterocyclic aromatic ring which may include monocyclic or fused polycyclic rings, halo, —OR′, —NR′R″, —CF 3 , —CN, —NO 2 , —C≡CR′, —SR′, —N 3 , —C(═O)NR′R″, —NR′C(═O)R″, —C(═O)R′, —C(═O)OR′, —OC(═O)R′, —O(CR′R″) r C(═O)R′, —O(CR′R″) r NR″C(═O)R′, —O(CR′R″) r NR″SO 2 R′, —OC(═O)NR′R″, —NR′C(═O)OR″, —SO 2 R′, —SO 2 NR′R″, and —NR′SO 2 R″, where R′ and R″ are individually hydrogen, straight chain or branched C 1 -C 8 alkyl, C 3-8 cycloalkyl, 3- to 10-membered heterocyclyl, aryl, or arylalkyl wherein the aryl is a 5- or 6-membered carbocyclic or heterocyclic aromatic ring which may include monocyclic or fused polycyclic rings, or R′ and R″ can combine with the nitrogen atom to which the R′ and R″ are attached to form a 3- to 10-membered cyclic functionality, and r is an integer from 1 to 6; or a salt thereof, wherein the compound includes a radiolabel selected from the group consisting of 11 C, 18 F , 76 Br, 123 I, and 125 I.