Patent ID: 8859605

Claim:
A compound of the formula I: wherein R 1a is H; and R 1b C 1 -C 6 alkyl, optionally substituted with 1-3 substituents independently selected from: halo, hydroxy, cyano, azido, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, amine, C 1 -C 4 alkylamine, C 1 -C 4 dialkylamine, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulfonylamino, aminocarbonyl, aminosulphonyl, Carbocyclyl and Het; or R 1b is Carbocyclyl or Het; or R 1a and R 1b together with the N atom to which they are attached define a saturated cyclic amine with 3-6 ring atoms; wherein the Carbocyclyl, Het or cyclic amine is optionally substituted with 1-3 substituents independently selected from halo, hydroxy, cyano, azido, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, amine, C 1 -C 4 alkylamine, C 1 -C 4 dialkylamine, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulfonylamino, aminocarbonyl, aminosulphonyl, RxOOC—C 0 -C2alkylene (where Rx is H, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl), phenyl, benzyl or C 3 -C 6 cycloalkylC 0 -C 2 alkylene; wherein the phenyl, benzyl or cycloalkyl moiety is optionally substituted with 1-3 substituents independently selected from halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl or C 1 -C 4 alkoxy); R 2a and R 2b are independently selected from H, halo, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, or R 2a and R 2b together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl; R 3 is a C 5 -C 10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy; or R 3 is a C 2 -C 4 alkyl chain with at least 2 chloro or 3 fluoro substituents; or R 3 is C 3 -C 7 cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy; R 4 is C 1 -C 6 alkyl, C 1 -C 6 dihaloalkyl, C 1 -C 6 alkylamino or C 1 -C 6 dialkylamino; Het is a stable, monocyclic or bicyclic, saturated, partially saturated or aromatic ring system containing 1-4 heteroatoms independently selected from O, S and N, each ring having 5 or 6 ring atoms; Carbocyclyl is C 3 -C 6 cycloalkyl, C 5 -C 6 cycloalkenyl or phenyl; or a pharmaceutically acceptable salt, hydrate or N-oxide thereof.