Patent ID: 7572809

Claim:
A compound according to wherein: (a) R 1 is selected from the group consisting of: hydrogen, alkyl, and cycloalkyl; (b) R 2 is hydrogen or alkyl; (c) R 3 is selected from the group consisting of: (1) unsubstituted alkyl, (2) alkyl which is substituted one or two times with —C(O)O-alkyl, heteroaryl, phenyl, heterocyclyl or cycloalkyl, (3) alkyl wherein one or more —CH 2 — groups are replaced by oxygen, (4) aryl which is optionally substituted one or more times with halogen, alkyl, halogenated alkyl, halogenated alkoxy, cyano, —C(O)-alkyl, —NH—C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, unsubstituted alkoxy, alkoxy substituted by heterocyclyl, or —NR 2 , (5) heteroaryl which is optionally substituted one or more times with alkyl, (6) cycloalkyl, and (7) heterocyclyl; (d) R 3a is selected from the group consisting of: hydrogen, alkyl, and alkoxy; (e) R 4 is selected from the group consisting of: hydrogen, alkyl, alkoxy, halogen, cyano, —C(O)NR 2 , —(CH 2 ) n —Y—R 7 , and Z-R 8 ; (f) R 5 is selected from the group consisting of: hydrogen, alkyl, alkoxy, halogen, cyano, —C(O)NR 2 , —(CH 2 ) n —Y—R 7 , and Z-R 8 ; and R 6 is selected from the group consisting of: hydrogen, alkyl, alkoxy, halogen, and cyano; or alternatively, R 5 and R 6 form, together with the carbon atoms to which they are attached, a 5- or 6-membered heterocyclic ring; (g) X is selected from the group consisting of: a single bond, —NR—, —O—, —S—, —C(O)—, and —C(O)NR—; (h) Y is selected from the group consisting of: —O—, —NR—, —S—, —S(O) 2 NR—, —NRC(O)—, —NRC(O)O—, and —C(O)NR—; (i) Z is selected from the group consisting of: —C(O)—, —O—, a single bond, and alkylene; (j) R 7 is cycloalkyl; or alkyl, which is optionally substituted one or more times by alkoxy, hydroxyl, alkylsulfonyl, heterocyclyl or NR 2 ; (k) R 8 is heterocyclyl; (l) R is hydrogen or alkyl; and (m) n is 0, 1, 2 or 3; or a pharmaceutically-acceptable salt or ester thereof.