Patent ID: 7319150

Claim:
A method for synthesizing derivatives corresponding to formula (I): in which: R 1 , R 2 , R 3 , at the 2, 3, 4, 5 or 6 position of the phenyl ring, which are identical or different, are chosen from: a hydrogen atom; C 1 -C 6 alkyls; C 2 -C 6 alkenyls; C 2 -C 6 alkynyls; halogens, C 1 -C 6 haloalkyls; —OH; the groups —OR′, —SH, —SR′, —SeH, —SeR′, —C(O)R′, —NHC(O)R′, —C(S)R′, —NHC(S)R′, —CN in which R′ represents a group chosen from C 1 -C 6 alkyls, C 2 -C 6 alkenyls, C 2 -C 6 alkynyls; the groups —C(O)OR″, —OC(O)R″, —NR″R′″ in which R″ and R′″, which are identical or different, represent a group chosen from a hydrogen atom, C 1 -C 6 alkyls, C 2 -C 6 alkenyls, C 2 -C 6 alkynyls; X and Y represent a pair of atoms chosen from: (NR 4 , N) (pyrazole ring), (O, N) (isoxazole ring), (S, N) (isothiazole ring), R 4 being chosen from: a hydrogen atom; C 1 -C 6 alkyls; the groups CH 2 —OR 5 , the groups C(O)OR 5 in which R 5 is chosen from a hydrogen atom, a C 1 -C 6 alkyl group, a benzyl group; the heterocycle is linked to the phenyl ring via its 3- or 5- position in the case of the pyrazole ring, via its 5-position in the case of the isoxazole and isothiazole rings; n represents an integer chosen from 0, 1, 2, 3, 4, 5 and 6; Z, at the 3- or 4-position of the isoxazole, pyrazole or thioxazole ring, represents a group chosen from: a hydrogen atom; C 1 -C 6 alkyls; C 2 -C 6 alkenyls; C 2 -C 6 alkynyls; halogens, C 1 -C 6 haloalkyls; —OH; the groups —OR′, —SH, —SR′, —SeH, —SeR′, —C(O)R′, —NHC(O)R′, —C(S)R′, —NHC(S)R′, —CN in which R′ represents a group chosen from C 1 -C 6 alkyls, C 2 -C 6 alkenyls, C 2 -C 6 alkynyls; the groups —C(O)OR″, —OC(O)R″, —NR″R′″ in which R″ and R′″, which are identical or different, represent a group chosen from a hydrogen atom, C 1 -C 6 alkyls, C 2 -C 6 alkenyls, C 2 -C 6 alkynyls, this method being characterized in that it comprises at least one step consisting in treating the product corresponding to formula (II) below in which R 1, R 2, R 3, X, Y, Z and n have the same definition as in formula (I) above, in alcohol in the presence of a base to give the product of formula (I): A and B being chosen such that one of A and B is H, the other being —OH.