Patent ID: 8772343

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: Z is a group selected from naphthyl, phenyl and Het 1 , said group being optionally independently substituted by one to three substituents selected from Y 1 and Y 2 ; Y 1 and Y 2 are independently selected from F; CI; CN; (C 1 -C 8 )alkyl, optionally substituted by (C 3 -C 8 )cycloalkyl or one to three F; (C 3 -C 8 )cycloalkyl, optionally substituted by one to three F; NR 7 R 8 ; (C 1 -C 8 )alkyloxy, optionally independently substituted by one to three R 9 ; (C 3 -C 8 )cycloalkyloxy; phenyl, optionally independently substituted by one to three R 10 ; Het 2 ; and Het 3 ; wherein (C 3 -C 8 )cycloalkyloxy may be optionally fused to a phenyl ring or may be independently substituted by one to three R 10 ; R 1 is (C 1 -C 6 )alkyl or (C 3 -C 8 )cycloalkyl, each of which is optionally substituted by one to three F; R 2 , R 3 , R 4 are independently H, F, Cl or —OCH 3 ; R 5 is phenyl optionally substituted by one to three substituents independently selected from CN, CI, F and R 6 ; or Het 3 ; R 6 is a group selected from (C 1 -C 6 )alkyl and (C 1 -C 6 )alkyloxy, wherein each group is optionally substituted, valency permitting, by one to five F; R 7 and R 8 are independently H; (C 1 -C 8 )alkyl, optionally independently substituted by one to three R 11 ; (C 3 -C 8 )cycloalkyl; or ‘C-linked’ Het 2 ; wherein (C3-C8)cycloalkyl may be optionally fused to a phenyl ring or may be independently substituted by one to three R 10 ; or R 7 and R 8 , taken together with the nitrogen atom to which they are attached, form a saturated, bridged, 7- to 9-membered ring; R 9 is F; (C 1 -C 6 )alkyloxy; (C 3 -C 8 )cycloalkyl, optionally substituted by one to three F; Het 1 ; or phenyl, optionally independently substituted by one to three R 6 ; R 10 is F, Cl or R 6 ; R 11 is F; (C 1 -C 6 )alkyloxy; (C 3 -C 8 )cycloalkyl, optionally substituted by one to three F; ‘C-linked’ Het 1 ; or phenyl, optionally independently substituted by one to three R 6 ; Het 1 is a 6-, 9- or 10-membered heteroaryl comprising one to three nitrogen atoms; Het 2 is a 3- to 8-membered saturated monoheterocycloalkyl comprising one or two ring members selected from —NR 12 — and —O—, said monoheterocycloalkyl being optionally substituted on a ring carbon atom by one to three substituents independently selected from F, (C 1 -C 6 )alkyl, (C 1 -C 4 )alkyloxy(C 0 -C 4 )alkylene and (C 3 -C 8 )cycloalkyl; Het 3 is a 5- or 6-membered heteroaryl comprising one to three nitrogen atoms, said heteroaryl being optionally substituted by one to three substituents selected from F, Cl, CN and R 6 ; and R 12 is H, (C 1 -C 6 )alkyl or (C 3 -C 8 )cycloalkyl, wherein (C 1 -C 6 )alkyl and (C 3 -C 8 )cycloalkyl are optionally substituted by one to three F; or, when Het 2 is ‘N-linked’, is absent.