Patent ID: 8470544

Claim:
A method of determining the presence or absence of dysplastic or neoplastic cervical cells in a test sample containing cells from an individual, wherein the test sample comprises a cervical cytology sample, the method comprising: contacting the test sample with an antibody or antibody fragment directed against Minichromosome Maintenance protein 3 (MCM3 protein); determining the amount and/or pattern of binding of said antibody or antibody fragment to said test sample; whereby an increase in said amount and/or a difference in said pattern if detected for the test sample compared with a normal sample is indicative of presence of dysplastic or neoplastic cervical cells in said test sample; and if an increase in said amount and/or a difference in said pattern is detected for the test sample compared with a normal sample, selecting the individual from which the test sample was obtained for a Pap smear test, a human papilloma virus (HPV) test and/or biopsy testing.