Patent ID: 8921381

Claim:
A pharmaceutical composition comprising: (a) an effective amount of one or more compounds of Formulas I or II, or an enantiomer, N-oxide, prodrug, protected derivative, stereoisomer or mixture of stereoisomers, or pharmaceutically acceptable salt or solvate thereof: wherein R 1 -R 4 are independently phenyl or Het, wherein each phenyl or Het is optionally substituted with at least one substituent independently selected from the group consisting of (C 1-7 )alkyl, (C 2-6 )alkenyl, (C 2-6 )alkynyl, (C 2-7 )alkanoyl, (C 2-7 )atkanoyloxy, (C 3-12 )cycloalkyl, (C 1-7 )acyl, aryl, halo, OR a , trifluoromethoxy, trifluoromethyl, NO 2 , NR a R b , cyano, CONR a R b , SO m R a , S(O) m NR a R b , P(═O)(OR a )(R a ), and Het, wherein (C 1-7 )alkyl or (C 3-12 )cycloalkyl are each independently optionally substituted with from 1 to 5 aryl, Het, OR a , halo, NO 2 , NR a R b , cyano, CONR a R b , CO 2 R, SO m R a , S(O) m NR a R b , or P(═O)(OR a )(R a ); X 1 -X 12 are independently a bond or a saturated or unsaturated alkylene group; R a and R b are each independently H, (C 1-7 )alkyl, (C 3-12 )cycloalkyl, (C 2-7 )alkanoyl, (C 2-7 )alkanoyloxy, or aryl, or R a and R b together with a nitrogen to which they are attached form a Het; m is 0, 1, or 2; n is 0, 1, 2, 3, or 4; and (b) a pharmaceutically acceptable carrier.