Patent ID: 6838491

Claim:
A process for applying a coating effective amount of at least one carboxyl functional hydrophilic polymer to a biomedical device, wherein said device is formed from a silicone elastomer, hydrogel, or silicone containing hydrogel which comprises hydroxyl groups, amino groups, or mixtures thereof, wherein the process comprises contacting at least one surface of said biomedical device with a coating effective amount of at least one carboxyl functional hydrophilic polymer and a coupling effective amount of at least one coupling agent, to form an ester or amide linkage between carboxyl functionality of said carboxyl functional hydrophilic polymer and said hydroxyl or amino groups, wherein the coupling agent is selected from the group consisting of carbodiimides, N,N′-carbonyldiimidazole, phosphoryl chloride, titanium tetracholoride, sulfuryl chloride fluoride, chlorosulfonyl isocyanate, phosphorus iodide, pyridinium salts of tributyl amine, phenyl dichlorophosphate, polyphosphate ester, chlorosilanes, a mixture of tributyl phosphorous and phenyl isocyanate, a mixture of alkyl chloroformates and triethyl amine, a mixture of 2-chloro- 1,3,5-trinitrobenzene and pyridine, a mixture of methyl sulfuryl chloride and diethyl amine, and a mixture of triphenylphosphine, carbon tetrachloride and triethylamine.