Patent ID: 8791079

Claim:
A method for ameliorating or reducing the severity of an adverse effect of a cardiac glycoside in a subject being treated with the cardiac glycoside for one or more conditions or symptoms associated with heart failure, the method comprising administering to the subject a therapeutically effective amount of a mitochondrial sodium-calcium exchanger (mNCE) inhibitor, wherein the mNCE inhibitor comprises a compound of Formula I: wherein: m and n are the same or different and are integers independently selected from the group consisting of 0, 1, 2, 3, and 4; Z is selected from the group consisting of O, S, and S(═O); R is selected from the group consisting of H, alkyl, and substituted alkyl; R 1 and R 2 are the same or different and at each occurrence are independently selected from the group consisting of halogen, alkyl, substituted alkyl, and nitro; or stereoisomers, prodrugs, or pharmaceutically acceptable salts thereof.