Patent ID: 8895545

Claim:
A compound of formula I: wherein, independently for each occurrence, A is a monocyclic ring of 4-7 atoms containing 0-2 heteroatoms, a bicyclic ring of 8-12 atoms containing 0-4 heteroatoms or a tricyclic ring of 8-12 atoms containing 0-6 heteroatoms wherein the rings are independently aliphatic, aromatic, heteroaryl or heterocyclic in nature, the heteroatoms are selected from the group consisting of N, S, and O, and the rings are optionally substituted with one or more groups selected from the group consisting of C 1-4 alkyl, OR″, CN, OCF 3 , F, Cl, Br, and I; wherein R″ is selected from the group consisting of H, alkyl, aralkyl, and heteroaralkyl, wherein the heteroaryl group of the heteroaralkyl is a 3-10 membered ring structure containing 1-4 heteroatoms selected from the group consisting of N, S, and O; R′ is selected from the group consisting of H and alkyl; R is selected from the group consisting of: wherein, independently for each occurrence, R 1 is OH; R 2 is OH; and R 3 is selected from the group consisting of H, alkyl, carbonyl, sulfonyl, or aryl; or a pharmaceutically acceptable salt thereof; wherein: carbonyl is —C(O)—X 50 —R 55 or —X 50 —C(O)—R 56 , where X 50 is a bond, oxygen, or sulfur; R 55 and R 56 are hydrogen, alkyl, alkenyl, or —(CH 2 ) m —R 61 ; R 61 is aryl, c cloalkyl, cycloalkenyl, or heterocyclyl; and m is zero or an integer in the range of 1 to 8; and sulfonyl is —S(O) 2 —R 58 , where R 58 is alkyl, alkenyl, alkenyl, cycloalkyl, heterocyclyl, aryl, or hetero aryl.