Patent ID: 7175913

Claim:
A hybrid particle for chromatographic separations, said particle having an interior area and an exterior surface, said particle having a composition represented by: [A] y [B] x (Formula 1), wherein x and y are whole number integers and A is SiO 2 /(R 1 p R 2 q SiO t ) n (Formula II) and/or SiO 2 /[R 3 (R 1 r SiO t ) m ] n (Formula III) wherein R 1 and R 2 are independently a substituted or unsubstituted C 1 to C 7 alkyl group, or a substituted or unsubstituted aryl group, R 3 is a substituted or unsubstituted C 1 to C 7 alkylene, alkenylene, alkynylene, or arylene group bridging two or more silicon atoms, p and q are 0, 1, or 2, provided that p+q=1 or 2, and provided that in Formula II, when p+q=1, t=1.5, and when p+q=2, t=1; r is 0 or 1, provided that in Formula III, when r=0, t=1.5, and when r=1, t=1; m is an integer greater than or equal to 2, and n is a number from 0.01 to 100; and further provided that when p is 0, q is 1, and t is 1.5, then n is 0.2 to 0.5; B is: SiO 2 /(R 4 v SiO t ) n (Formula IV) wherein R 4 is hydroxyl, fluorine, alkoxy, aryloxy, substituted siloxane, protein, peptide, carbohydrate, nucleic acid, or combinations thereof, R 4 is not R 1 , R 2 , or R 3 ; v is 1 or 2, provided that in Formula IV, when v=1, t=1.5, and when v=2, t=1; and n is a number from 0.01 to 100; said interior of said particle having a composition of A; said exterior surface of said particle having a composition represented by A and B, and wherein said exterior composition is between about 1 and about 99% of the composition of B and the remainder comprising A.