Patent ID: 8088786

Claim:
A layered pharmaceutical formulation for the administration of two or more active pharmaceutical ingredients comprising: a first pharmaceutical layer comprising between about 2 mg and about 35 mg of sustained-release naltrexone; a second pharmaceutical layer comprising between about 50 mg and about 200 mg of sustained-release bupropion; and an intermediate layer disposed between said first and said second pharmaceutical layers, wherein said intermediate layer comprising a monosaccharide sugar or a disaccharide sugar is configured to rapidly dissolve in vivo, and thereby leave said first and said second pharmaceutical layers substantially intact but physically separated, and wherein the dissolution profile of naltrexone in the pharmaceutical formulation is substantially the same as a single compressed tablet of naltrexone having the same size and shape as said first pharmaceutical layer, and wherein the dissolution profile of bupropion in the layered pharmaceutical formulation is substantially the same as a single compressed tablet of the same pharmaceutical composition, size and shape as said second pharmaceutical layer.