Patent ID: 8664356

Claim:
A peptide comprising one or more γ-amino acid residues, wherein at least one γ-amino acid residue is a residue of Formula IX or a residue of Formula X, wherein the structure of Formula IX is: wherein A is H, a nitrogen protecting group, an amino acid, or a chain of two or more amino acids; B is H, or a carboxylic acid protecting group, or —OB is an amino acid, or a chain of two or more amino acids; R 1 is alkyl, cycloalkyl, aryl, heteroaryl, or heterocycle; A 3 is carbon; A 4 is carbon or nitrogen; A 5 is carbon, or nitrogen provided A 6 is not a direct bond; A 6 is carbon or a direct bond; and each of A 3 -A 6 are optionally substituted with one or two alkyl, alkoxy, fluoro, optionally protected hydroxy, aryl, (aryl)alkyl, heteroaryl, heterocycle, cycloalkyl, alkanoyl, alkoxycarbonyl, optionally protected amino, optionally protected aminoalkyl, optionally protected alkylamino, dialkylamino, acylamino, trifluoromethyl, trifluoromethoxy, optionally protected carboxy, optionally protected carboxyalkyl, keto, arylsulfonyl, cyano, or azide groups, or when nitrogen, one nitrogen protecting group; and wherein each alkyl, cycloalkyl, aryl, heteroaryl, or heterocycle is optionally substituted with one to five alkyl, alkoxy, fluoro, optionally protected hydroxy, aryl, (aryl)alkyl, heteroaryl, heterocycle, cycloalkyl, alkanoyl, alkoxycarbonyl, optionally protected amino, optionally protected aminoalkyl, optionally protected alkylamino, dialkylamino, alkylaminoalkyl, dialkylaminoalkyl, acylamino, trifluoromethyl, trifluoromethoxy, optionally protected carboxy, optionally protected carboxyalkyl, keto, arylsulfonyl, cyano, or azide groups; and the structure of Formula X is: wherein A is H, a nitrogen protecting group, an amino acid, or a chain of two or more amino acids; B is H, or a carboxylic acid protecting group, or —OB is an amino acid, or a chain of two or more amino acids; R 1 is alkyl, cycloalkyl, aryl, heteroaryl, or heterocycle, or hydrogen provided that the peptide comprises a residue of Formula IX; wherein the alkyl, cycloalkyl, aryl, heteroaryl, or heterocycle of R 1 is optionally substituted with one to five alkyl, alkoxy, fluoro, protected hydroxy, aryl, (aryl)alkyl, heteroaryl, heterocycle, cycloalkyl, alkanoyl, alkoxycarbonyl, protected amino, alkylamino, dialkylamino, acylamino, trifluoromethyl, trifluoromethoxy, carboxy, carboxyalkyl, keto, arylsulfonyl, cyano, or azide groups; A 3 is carbon; A 4 is carbon; A 5 is carbon; and A 6 is carbon, or a direct bond.