Patent ID: 7166627

Claim:
A pharmaceutical composition which comprises: a. a 5-isoxazolidinone compound, a pharmaceutically acceptable salt thereof, or an in-vivo-hydrolysable ester thereof, having the general formula (II): wherein R 1 , and R 2 , are the same or different, selected from the group consisting of: (a) hydrogen; (b) alkyl, aryl, aralkoxy, aralkyl, cycloalkyl, alkynyl, alkenyl, alkoxy, carboxy, carbalkoxy, carbalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, hydroxyalkyl, acyl, carbamoyloxy, acyloxy, aryloxy, alkylthio, alkylsulfinyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, isomeric alkyl among other groups, each which may be saturated and unsaturated and each which may be substituted with Z 1 , Z 2 and Z 3 ; (c) halogen; (d) hydroxyl; (e) cyano; (f) nitro; (g) —C(O)H or —C(O)R 6 ; (h) —CO 2 H or —CO 2 R 6 ; (i) -Z 4 -NR 7 R 8 ; or (j) -Z 4 -N(R 11 )-Z 5 -NR 9 R 11 ; wherein R 6 , R 7 , R 8 , R 9 , R 10 , and R 11 , are each independently (a) hydrogen; or (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1 , Z 2 and Z 3 ; wherein Z 1 , Z 2 and Z 3 are each independently (a) hydrogen; (b) halo; (c) hydroxy; (d) alkyl; (e) alkenyl; (f) aryl; (g) aralkyl; (h) alkoxy; (i) aryloxy; (j) aralkoxy; (k) heterocycle, substituted heterocycle or heterocyclooxy; (l) —SH, —S(O)n Z 4 , —S(O)m—OH, —S(O)m—OZ 4 , —O—S(O)m-Z 4 , —O—S(O)m OH or —O—S(O)m—OZ 4 ; (m) oxo; (n) nitro; (o) cyano; (p) —C(O)H or —C(O)Z 4 ; (q) —CO 2 H or —CO 2 Z 4 ; and wherein Z 4 is alkyl; alkyl substituted with one to three groups selected from halogen, aryl, aryloxy and alkoxy; alkenyl; alkynyl; cycloalkyl; cycloalkyl substituted with one to three groups selected from alkyl, aryl, alkenyl and alkoxyaryl; cycloalkyl to which is fused a benzene ring; aryloxy substituted with one or two halogens; cycloalkylalkyl; cycloalkenyl; cycloalkenylalkyl; aryl; aryl substituted with methylenedioxy or one to four groups selected from alkyl, dialkylamino, cyano, halogen, trihaloalkyl, alkoxy, trihaloalkoxy, dialkylaminocarbonyl, alkylcarbonylamino, arylalkoxy, aryloxyalkyl, alkylaryloxyalkyl and heterocycle; and substituted compounds thereof; and b. a pharmaceutically acceptable diluent or carrier.