Patent ID: 8013003

Claim:
A compound according to the formula: wherein: W is oxygen; X, Y and Z are each independently —CR, wherein: R is H, —Br, —Cl, —F, —CN, —NO 2 , —OR 1 , —SR 1 , —NR 1 2 , —C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted, wherein: R 1 is H, —C 1 -C 6 branched or un-branched alkyl which, may be un-substituted or substituted, F═O or S, A is H, or —C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted, —C 2 -C 6 branched or un-branched alkenyl, which may be un-substituted or substituted, —C 2 -C 6 branched or un-branched alkynyl, which may be un-substituted or substituted, —C 3 -C 7 cycloalkyl which may be un-substituted or substituted, —C 3 -C 7 alkylcycloalkyl which may be un-substituted or substituted, aryl or heterocycle which may be un-substituted or substituted, alkylaryl which may be un-substituted or substituted, alkylheterocycle which may be un-substituted or substituted n=0, 1, 2, 3, 4, 5, or 6; is a —C 3 -C 7 cycloalkyl which may be un-substituted or substituted, a —C 4 -C 7 azacycloalkyl, which may be un-substituted or substituted, a —C 7 -C 10 bicycloalkyl which may be un-substituted or substituted, a —C 7 -C 10 azabicycloalkyl which may be un-substituted or substituted, aryl which may be un-substituted or substituted or a heterocycle which may be un-substituted or substituted; B is —C═, C—R a , O, N, S, C═O, S═O or SO 2 ; R a is H, a halogen (preferably F), OH, Oalkyl, cyano, or a —C 1 -C 6 alkyl group which is un-substituted or substituted and which optionally, forms a C 3 -C 7 cycloalkyl group with D; and D is absent when B is O, S, C═O, S═O or SO 2 , or if present, is bonded to B when B is —C═, —C—R a or N, and is H, a halogen (preferably F), OR b , a —C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted and which optionally, forms a C 3 -C 7 cycloalkyl group with R a , a —C 2 -C 6 branched or un-branched alkenyl, which may be un-substituted or substituted, a —C 2 -C 6 branched or un-branched alkynyl, which may be un-substituted or substituted, a —C 3 -C 7 cycloalkyl which may be un-substituted or substituted, an aryl which may be un-substituted or substituted, a heterocycle which may be un-substituted or substituted, a —C 2 -C 7 carboxyalkyl which may be un-substituted or substituted, a carboxyaryl which may be un-substituted or substituted, a carboxyheteroaryl which may be un-substituted or substituted, a —C 1 -C 7 sulfonylalkyl which may be un-substituted or substituted, a sulfonylaryl which may be un-substituted or substituted or a sulfonylheteroaryl which may be un-substituted or substituted, or when B is —C—R a , R a and D optionally form a ═N—R c or a ═N—OR c group with B, wherein R c is H or an unsubstituted or substituted C 1 -C 7 alkyl group; and R b is H, a —C 1 -C 7 alkyl group which may be branched or un-branched, un-substituted or substituted or a —C 2 -C 7 acyl group which may be un-substituted or substituted; or a pharmaceutically acceptable salt or pro-drug thereof.