Patent ID: 7674787

Claim:
A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein: A is NR 1 R 2 , or N + R 1 R 2 R 3 ; R 1 , R 2 , and R 3 are independently hydrogen or optionally substituted C 1-8 alkyl, C 2-8 alkenyl, or C 2-8 alkynyl, in which one or more carbons can be replaced by C═O, C═S, or a heteroatom selected from O, S, and N, and one or more hydrogens in CH, CH 2 or CH 3 groups can be replaced by fluorine, a branched or unbranched alkyl or cycloalkyl, an optionally substituted aryl, alkylaryl, heteroaryl, or alkylheteroaryl, or OR 4 , SR 4 , or NR 4 R 5 ;R 4 , and R 5 are independently hydrogen or optionally substituted C 1-4 alkyl, C 2-5 alkenyl, or C 2-5 alkynyl, in which one or more carbons can be replaced by a heteroatom selected from O, S, and N, or optionally substituted aryl, alkylaryl, heteroaryl, or alkylheteroaryl; or any two of R 1 , R 2 , and R 3 taken together with the nitrogen to which they are attached form a heterocyclic group, in which one or more carbon atom can be replaced by C═O, C═S, or a heteroatom selected from O, S, and N, with the proviso that the heteroatom is separated from the nitrogen atom by at least two carbons; B is optionally substituted C 1-4 alkyl, C 2-4 alkenyl, or C 2-4 alkynyl, wherein one or more hydrogens can be replaced by fluorine; U is CONH, C(O)O, C(S)O, C(S)NH, C(NH)NH, or (CH 2 ) 1-5 , wherein one or more carbons can be replaced by a heteroatom selected from O, S, and N; V and W are independently (CH 2 ) 1-5 , wherein one or more carbons can be replaced by C═O, C═S, or a heteroatom selected from O, S, and N, and one or more hydrogens in CH 2 groups can be replaced by a branched or unbranched alkyl or cycloalkyl, an optionally substituted aryl, alkylaryl, heteroaryl, or alkylheteroaryl, or OR 4 , SR 4 , or NR 4 R 5 ; X is optionally substituted C 1-18 alkyl, C 2-18 alkenyl, C 2-18 alkynyl, aryl, or heteroaryl, wherein one or more carbons can be replaced by C═O, C═S, or a heteroatom selected from O, S, and N, and one or more hydrogens in CH, CH 2 or CH 3 groups can be replaced by a branched or unbranched alkyl or cycloalkyl, an optionally substituted aryl, alkylaryl, heteroaryl, or alkylheteroaryl, or OR 4 , SR 4 , or NR 4 R 5 ; Y is N and forms a bicyclic ring system with one of the ring being a seven-membered ring; Z is CH 2 , C═O, C═S, CHSR, CHOR, or CHNR; and R is hydrogen or optionally substituted C 1-4 alkyl, C 2-4 alkenyl, or C 2-4 alkynyl.