Patent ID: 8778382

Claim:
A transdermal dosage form comprising: an active agent component having a proximal, skin contacting surface and a distal surface and comprising an opioid agonist; an adverse agent component having a proximal surface and a distal surface and comprising an opioid antagonist; a backing; a barrier having a proximal surface and a distal surface that is interposed between the active agent component and the adverse agent component, wherein one or more channels extend completely from the proximal surface of the active agent component to the distal surface of the barrier and terminate prior to the proximal surface of the adverse agent component; wherein air is disposed in one or more channels; and wherein the barrier is permeable to a solvent selected from the group consisting of water, ethanol, ether, and mixtures thereof, and wherein the barrier is impermeable to diffusion of opioid agonist and opioid antagonist in the absence of said solvent.