Patent ID: 7201890

Claim:
A method of close-range detection of lesions during an operative, endoscopic, laparoscopic, intravascular catheter, or surgical procedure, wherein the method comprises: (a) injecting a patient who is to undergo such a procedure with a bispecific antibody fragment or subfragment with a molecular weight of 85,000 daltons or less, wherein the bispecific antibody fragment has a first antibody binding site which specifically binds to an antigen produced or associated with a lesion, and has a second antibody binding site which specifically binds to a hapten, and permitting the antibody fragment to accrete at target sites; (b) injecting a bivalent labeled hapten, which quickly localizes at the target site and clears through the kidneys; and (c) detecting the presence of the hapten by close-range detection of elevated levels of accreted label at the target sites with detection means, within 48 hours of the first injection, and conducting said procedure.