Patent ID: 8562987

Claim:
A method for treating a cancer in a human subject, comprising administering to the subject having a CD70 expressing cancer an effective amount of a humanized antibody or antigen binding fragment, comprising: (i) a humanized heavy chain comprising the three CDRs from SEQ ID NO:2 and a variable region framework sequence of human germline V H 1-2 or V H 1-18 and exon J H -6, provided that any of positions H46, H67, H68, H69, H70, H71, H80, H81, H82, H82A and H91 (Kabat numbering) can be occupied by the amino acid occupying the corresponding position from SEQ ID NO:2, and (ii) a humanized light chain comprising the three CDRs from SEQ ID NO:22 and a variable region framework sequence of human germline Vκ exon B3 and Jκ exon Jκ-1, provided that any of positions L25 and L33 can be occupied by the amino acid occupying the corresponding position from SEQ ID NO:22.