Patent ID: 6998502

Claim:
A process to manufacture-Difluoromethylornithine, its analogs and derivatives represented by formula I wherein R 1 is hydrogen; R 2 is hydroxy, C 1 –C 8 alkoxy, —NR′R″, wherein R′ and R″ are independently hydrogen, C 1 –C 8 alkyl groups; R 3 is hydrogen; R 4 is —CH 2 F, —CHF 2 , —CF 3 and the salts thereof, and the process comprising the step of hydrolyzing the halomethylated compounds of formula IIA, under acid conditions; wherein: R 4 is —CH 2 F, —CHF 2 , —CF 3 , R 5 is hydrogen, C 1 –C 8 alkyl groups; R 6 is monohalogen substituents such as o,m,p-chloro or o,m,p-bromo; or dihalogen substituents such as 3,4-dichloro; 2,6-dichloro; 3,4-dibromo and other positional isomers thereof; or polyalkoxy substituents; and R 7 is C 1 –C 4 alkyl, halogens such as chlorine or bromine.