Patent ID: 8632774

Claim:
An isolated polypeptide comprising a binding domain which can specifically bind to a human IL6/IL6R (IL6xR) complex, wherein the binding domain (a) specifically binds to the human IL6xR complex with a higher affinity than to either human IL6 or human IL6Rα alone; (b) can compete with a gp130 for binding to a soluble human IL6xR complex; and (c) comprises an antibody light chain variable region, wherein the antibody light chain variable region comprises CDR1, CDR2, and CDR3 sequences found in amino acids 649-758 of SEQ ID NO:608, and an antibody heavy chain variable region, wherein the antibody heavy chain variable region comprises CDR1, CDR2, and CDR3 sequences found in amino acids 512-631 of SEQ ID NO:608, and wherein the CDRs are defined by the Kabat, Chothia, AbM or contact definition.