Patent ID: 8501812

Claim:
A method for treating type I diabetes in a subject, comprising administering a compound that inhibits the activity of JNK2 in said subject, wherein said compound has the following formula: wherein: Ar 1 is a substituted or unsubstituted aryl or heteroaryl group; X is O or S; Ar 2 a substituted or unsubstituted aryl or heteroaryl group; R 1 and R 2 are independently selected from the group consisting of hydrogen and a C 1 -C 6 alkyl group; R a , R a′ , R b , R b′ are independently selected from the group consisting of hydrogen and C 1 -C 6 -alkyl; or R a′ and R a or R b′ together with the carbon atoms they are linked, form a substituted or unsubstituted 5-8-membered saturated, partially unsaturated or aromatic ring containing optionally one or more heteroatoms selected from O, N, S; R 3 is selected from the group consisting of H, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, aryl, heteroaryl, 3-8 membered cycloalkyl optionally containing 1-3 heteroatoms selected from the group consisting of N, O, and S; aryl C 1 -C 10 -alkyl and heteroaryl C 1 -C 10 -alkyl; or R 3 and R a or R a′ form, together with the N atom linked to R 3 , a 5-8-membered saturated ring, containing optionally at least one further heteroatom selected from O, N, S; R 4 is selected from the group consisting of H and —C(H)R 5 R 6 ; R 5 and R 6 are independently selected from the group consisting of H, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, aryl, hetero aryl, 3-8 membered cycloalkyl optionally containing 1-3 heteroatoms selected from the group consisting of N, O, and S; aryl C 1 -C 10 -alkyl and heteroaryl C 1 -C 10 -alkyl; m is an integer from 1 to 5, n is an integer from 0 to 2, and p is an integer from 1 to 10.