Patent ID: 7202348

Claim:
A monoclonal antibody or an antigen binding fragment thereof that specifically recognizes d-methamphetamine, d-amphetamine, (+/−) 3,4-methylenedioxymethamphetamine or (+/−) 3,4-methylenedioxyamphetamine, wherein said monoclonal antibody or the antigen binding fragment thereof is generated using an immunogen comprising a substituted d-methamphetamine as a hapten and an immunogenic carrier, wherein said substituted d-methamphetamine has a structure wherein R is substituted on the aromatic ring at one of C2, C3 or C4; wherein R is —ZR 2 COOR 1 ; Z is O or S; R 1 is H or R 4 ; R 2 is a C 2-9 alkyl chain containing an O or a N(R 3 ) moiety therein, a C 2-9 alkenyl chain or a C 2-9 alkynyl chain; R 3 is C 1-5 alkyl; and R 4 is —CH 2 CH 2 CN, 4-nitrophenyl, 2,3,4,5,6-pentafluorophenyl; or 2,3,5-trichlorophenyl; or a hydrochloride salt thereof.