Patent ID: 7115738

Claim:
A compound comprising the structure: wherein G is selected from a group consisting of H and a protecting group; wherein E is selected from a group consisting of O—, OH, a protecting group, and an activating group; wherein each B 1 and B 2 is independently selected from the group consisting of H and a nucleobaso, and wherein amino groups, if present, are, optionally, protected by amino protecting groups; wherein each A 1 and each A 2 is, independently, a group of formula (Ia), (Ib), or (Ic); wherein r and s are, for I(a), I(b), and I(c) independently of one another, values from 0 to 5; wherein each R 1 and each R 2 is, independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, hydroxy, alkoxy, alkylthio, amino, or halogen; wherein each R 4 and each R 5 , is, independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, hydroxy, alkoxy, amino, aryl, aralkyl, heteroaryl, or an amino acid side chain; Y is a single bond, O, S, or NR 4 ; and X is O, S, Se, NR 4 , CH 2 , or C(CH 3) 2 ; wherein each R 6 is, independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkylthio-substituted (C 1 –C 6 )alkyl, aryl, aralkyl, heteroaryl, or an amino acid side chain; wherein R 7 is, independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino, or alkythio-substituted (C 1 –C 6 )alkyl, hydroxy, alkoxy, alkylthio, amino, aryl, aralkyl, heteroaryl, or hydrogen, and R 8 is hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, aryl, aralkyl, or heteroaryl; or R 7 is hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, aryl, aralkyl, or heteroaryl, and R 8 is hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, hydroxy, alkoxy, alkylthio, amino, aryl, aralkyl, heteroaryl, or halogen; wherein each R 9 independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, alkoxy, aryl, arylkyl, or heteroaryl; wherein each R 10 and each R 11 is, independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, aryl, aralkyl, heteroaryl, or an amino acid side chain; wherein each R 12 , R 13 , R 14 , R 15 , R 16 , and each R 17 is, independently, hydrogen, (C 1 –C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, hydroxy, alkoxy, alkylthio, aryl, aralkyl, heteroaryl, or an amino acid side chain; wherein T is hydrogen, (C 1 C 6 )alkyl, hydroxy-, alkoxy-, amino-, or alkythio-substituted (C 1 –C 6 )alkyl, hydroxy, alkoxy, alkylthio, aryl, aralkyl, heteroaryl, or an amino acid side chain; and n is 1 or greater, and salts thereof.