Patent ID: 8357706

Claim:
A compound having the structure of Formula I-R or I-S or a pharmaceutically acceptable salt, ester, hydrate or solvate thereof: wherein X is —NR′R″ or —OR′″; Y is —CN, —Cl, or —CF 3 ; R′ is H, C 1-4 alkyl, n-hydroxy C 1-4 alkyl, —SO 2 —R 1 , or —CO—R 1 ; R″ is H, —SO 2 —R 3 , C 1-4 alkyl optionally substituted with 1 or more R 2 , or a ring moiety optionally substituted with R 4 wherein such ring moiety is piperidinyl, cyclohexyl, morpholinyl, thiazolyl, pyrazolyl, pyrrolidinyl, imidazolyl, or phenyl; or R′ and R″ taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally singly or multiply substituted with substituents independently selected from the group consisting of —OH, oxo, —NH 2 , n-hydroxy-C 1-4 alkyl, —COOH, —(CH 2 ) m —COOH, —(CH 2 ) m —COOR 1 , —N(R 1 R 1 ), and —(CH 2 ) m —CO—N(R 5 R 5 ); R′″ is H, C 1-4 alkyl, or —CO—R 1 ; each R 1 is independently C 1-4 alkyl or H; each R 2 is independently H, halo, OH, oxo, ═NH, NH 2 , —COOH, F, —NHR 1 ,—N(R 5 R 5 ),—SO 2 —R 1 , —SO 2 —N(R 5 R 5 ), —N(R 1 )—SO 2 —R 1 , —COOR 1 , —OCO—R 1 , —CO—N(R 5 R 5 ), —N(R 1 )—COR 1 , C 1-3 alkyl, C 1-3 alkoxy, and a ring moiety optionally substituted with R 4 wherein such ring moiety is piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrazolyl, imidazolyl, benzimidazolyl, azetidinyl, cyclobutinyl, or phenyl; each R 3 is independently R 2 , C 1-4 alkyl, C 3-6 cycloalkyl, or C 1-4 alkyl optionally substituted with 1 or more R 2 ; each R 4 is independently halo, OH, —NH 2 , —NHR 1 , —N(R 1 R 1 ), —COOH, —COOR 1 , —NHCO—R 1 ; each R 5 is independently C 1-4 alkyl or H, or two R 5 taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally substituted with —OH, —NH 2 , —N(R 1 R 1 ), n-hydroxy C 1-4 alkyl, —(CH 2 ) m —COOH, —(CH 2 ) m —COOR 1 ; and each m is independently 0, 1, 2, or 3.