Patent ID: 7235535

Claim:
A method of enhancing drainage of the lacrimal system comprising the step of administering to the eyes of a subject an effective amount of a preparation comprising a compound selected from the group consisting of uridine 5′-triphosphate and derivatives as depicted in Formula I, adenosine 5′-triphosphate derivatives as depicted in Formula III, and cytidine 5′-triphosphate derivatives as depicted in Formula IV, or their pharmaceutically acceptable salts; whereby said preparation is effective in enhancing drainage of the lacrimal system in the eyes in the subject: wherein: X 1 , X 2 and X 3 are each independently either O − or S; R 1 is O, imido, methylene or dihalomethylene; R 2 is H or Br; wherein: R 1 , X 1 , X 2 and X 3 are defined as in Formula I; R 3 and R 4 are H while R 2 is nothing and there is a double bond between N-1 and C-6, or R 3 and R 4 are H while R 2 is O and there is a double bond between N-1 and C-6, or R 3 , R 4 and R 2 taken together are —CH═CH—, forming a ring from N-6 to N-1 with a double bond between N-6 and C-6; wherein: R 1 , X 1 , X 2 and X 3 are defined as in Formula I; R 5 and R 6 are H while R 7 is nothing and there is a double bond between N-3 and C-4, or R 5 , R 6 and R 7 taken together are —CH═CH—, forming a ring from N-3 to N-4 with a double bond between N-4 and C-4 optionally substituted at the 4- or 5-position of the etheno ring.