Patent ID: 8221596

Claim:
A high impedance system for generating an electric field comprising: a pair of electrodes comprising a dielectric material wherein each electrode has at least one surface coated with an electrically conductive material, and wherein said dielectric material forms a barrier separating the conductive coating from the subject fluid under treatment, said dielectric material having a combination of permittivity, maximum allowable electric field stress and volume resistivity for substantially forestalling electric conduction current through said subject fluid while simultaneously directing and generating said electric field through said subject fluid with sufficient field intensity and duration causing reversible and/or irreversible electroporation in biologic cells suspended in said subject fluid; a fluid pathway or space area formed between the pair of electrodes such that the conductive material is on an electrode surface not in contact with the subject fluid in the pathway or space; a time variant, time invariant, or pulsed voltage source applied across the electrodes; and a housing containing said pair of electrodes, said housing configured to maintain a subject static or dynamic fluid in said pathway or space.