Patent ID: 8524902

Claim:
A compound of formula I: wherein Ring A is a [1,2,4] triazolyl ring; X 1 is [a]-NR 8 ; R 1 is phenyl, wherein said R 1 is optionally substituted with 0-5 J 1 ; Each R 2 and R 3 is independently H or C 1-10 aliphatic; R 4 is C 3-10 cycloaliphatic or 3-10 membered heterocyclyl, wherein said R 4 is optionally substituted with 0-5 J 4 ; R 8 is H; Each J 1 is independently halo, Q, or —Z-Q; Each Z is independently C 1-6 aliphatic in which 0-3-CH 2 — units in said C 1-6 aliphatic are optionally replaced with —NR—, —O—, or —C(O)—, wherein any non-replaced —CH 2 — units in said C 1-6 aliphatic are optionally substituted with 0-2 J Z ; Each Q is independently H, C 1-6 aliphatic, a 3-8-membered aromatic or non-aromatic monocyclic ring having 0-3 heteroatoms independently selected from O, N, and S, or an 8-12 membered aromatic or non-aromatic bicyclic ring system having 0-5 heteroatoms independently selected from O, N, and S, wherein each Q is independently optionally substituted with 0-5 J Q ; Each J Q and J 4 is -M or —Y-M; Each Y is independently an unsubstituted C 1-6 aliphatic in which 0-3-CH 2 — units in said C 1-6 aliphatic are optionally replaced with —NR—, —O—, —S—, —C(O)—, —S(O)—, or —S(O) 2 —; Each M is independently H, C 1-6 aliphatic, C 3-6 cycloaliphatic, halo(C 1-4 aliphatic), O(haloC 1-4 aliphatic), 3-6 membered heterocyclyl, halo, NO 2 , CN, OH, OR′, SH, SR′, NH 2 , NHR′, N(R′) 2 , COH, COR′, CO 2 H, CO 2 R′, CONH 2 , CONHR′, CONR′ 2 , OCOR′, OCONH 2 , OCONHR′, OCON(R′) 2 , NHCOR′, NR′COR′, NHCO 2 R′, NR′CO 2 R′, NHCO 2 H, NR′CO 2 H, NHCONH 2 , NHCONHR′, NHCON(R′) 2 , SO 2 NH 2 , SO 2 NHR′, SO 2 N(R′) 2 , NHSO 2 R′, or NR′SO 2 R′; Each R is independently H or unsubstituted C 1-6 aliphatic; and Each R′ is unsubstituted C 1-6 aliphatic, or two R′ groups, together with the atom to which they are bound, form an unsubstituted 3-8 membered saturated or partially unsaturated monocyclic ring having 0-1 heteroatoms independently selected from O, N, and S.