Patent ID: 7094777

Claim:
A compound of the formula I: wherein n is 0, 1, 2 or 3; W is CH 2 , CO, CHF or CH(OH); X is SO 2 , SO, CO or CH(OH); Y is CH 2 , CHF or CF 2 ; Z is H, F or OH; Ar 1 is phenyl or heteroaryl, wherein heteroaryl is selected from thiazole, imidazole and triazole, and wherein said phenyl or heteroaryl is unsubstituted or substituted with up to 3 substituents selected from halogen, CN, NO 2 , R 1 , OR 2 , COR 2 , CO 2 R 2 , OCOR 1 , SR 2 , S(O) t R 1 where t is 1 or 2, N(R 2 ) 2 , CON(R 2 ) 2 , NR 2 COR 1 and SO 2 N(R 2 ) 2 ; Ar 2 is a mono- or bicyclic ring system selected from phenyl, naphthyl, pyrrole, oxazole, isoxazole, thiazole, isothiazole, and imidazole, and their benzo-fused and tetrahydrobenzo-fused derivatives, wherein said ring system is unsubstituted or substituted with up to 3 substituents selected from halogen, CN, NO 2 , R 1 and OR 2 ; R 1 is C 1-6 alkyl or phenyl, which is unsubstituted or substituted with up to 5 fluorine substituents; and R 2 is R 1 or H; or two R 2 groups attached to the same nitrogen atom may form a pyrrolidine, imidazole or triazole ring, or a pharmaceutically acceptable salt or hydrate thereof.