Patent ID: 8889736

Claim:
A substantially nonaqueous therapeutic formulation for topical administration comprising a uniform liquid binary eutectic mixture of: (a) a capsaicinoid having the structure of formula (I) wherein R 1 is methoxy, R 2 is hydroxyl, X is and R is —(CH 2 ) 4 —CH═CH—CH(CH 3 ) 2 , wherein the capsaicinoid represents about 40 wt. % to about 70 wt. % of the formulation; and (b) a second active agent effective to decrease at least one side effect associated with capsaicin monotherapy, said second agent existing as a solid at 25° C., and wherein the second active agent is a local anesthetic selected from the group consisting of amylocaine, articaine, benzocaine, bupivacaine, butacaine, 2-chloroprocaine, cinchocaine, dexivacaine, diamocaine, dibucaine, etidocaine, ketocaine, lidocaine, mepivacaine, oxybuprocaine, parethoxycaine, prilocaine, procaine, propanocaine, proparacaine, propoxycaine, pyrrocaine, risocaine, rodocaine, ropivacaine, tetracaine, and combinations thereof; and wherein the formulation contains less than 5 wt. % water.