Patent ID: 8017735

Claim:
A composition comprising: (a) one or more isolated antibodies or antigen-binding fragments thereof, that specifically bind human insulin-like growth factor receptor 1, comprising a light chain immunoglobulin amino acid sequence which comprises CDR-L1 comprising the amino acid sequence set forth in SEQ ID NO: 5, CDR-L2 comprising the amino acid sequence set forth in SEQ ID NO: 6 and CDR-L3 comprising the amino acid sequence set forth in SEQ ID NO: 7; and a heavy chain immunoglobulin amino acid sequence which comprises CDR-H1 comprising the amino acid sequence set forth in SEQ ID NO: 8 or 12, CDR-H2 comprising the amino acid sequence set forth in SEQ ID NO: 9 and CDR-H3 comprising the amino acid sequence set forth in SEQ ID NO: 10; in association with (b) one or more chemotherapeutic agents selected from the group consisting of: lonafarnib; lapatinib; bevacizumab; VX-745; PD184352; temsirolimus; LY294002; LY292223; LY292696; LY293684; LY293646; wortmannin; sorafenib; ZM336372; L-779,450;