Patent ID: 8679751

Claim:
A method for particle filtration comprising: introducing a feed comprising particles into a feed inlet of a filtration device including at least one filtration module, the filtration module comprising a first flow chamber including at least one feed inlet, and at least one retentate outlet; a second flow chamber including a distal end having at least one filtrate outlet, and a first filter positioned between the first flow chamber and the second flow chamber, the first filter including a first row of pillars, a plurality of pores defined by spacings between adjacent pillars, and a plurality of sections, a first section having a small angle with a side wall of the filtration module and configured to draw a small amount of flow across the first section, and a second section having a large angle with the side wall of the filtration module and configured to draw a larger amount of flow through the second section than the small amount of flow, an effective pore size of the second section being larger than an effective pore size of the first section, each pore of the first filter having a physical pore size larger than the effective pore size of the second section; passing the feed through the filtration device, fluid flow configurations around the filter achieving the effective pore size of the first section and the effective pore size of the second section; collecting retentate comprising particles having a size larger than the effective pore size of the second section at the retentate outlet; and collecting filtrate comprising particles smaller than the effective pore size of the second section at the filtrate outlet.