Patent ID: 6951882

Claim:
A pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: R 2 is H, F, Cl, Br, I, cyano, nitro, COR a , COOR a , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, C 2-9 heterocyclyl, (phenyl)-C 1-6 alkylene, (C 2-9 heterocyclyl)-C 1-6 alkylene, or (C 3-7 cycloalkyl)-C 1-6 alkylene; wherein R a is H, C 1-6 alkyl, C 3-7 cycloalkyl, or (C 3-7 cycloalkyl)-C 1-6 alkylene; R 3 is H, F, Cl, Br, I, cyano, hydroxy, nitro, amino, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, C 2-9 heterocyclyl, (phenyl)-C 1-6 alkylene, (C 2-9 heterocyclyl)-C 1-6 alkylene, or (C 3-7 cycloalkyl)-C 1-6 alkylene or R 2 and R 3 taken together with the phenyl ring to which they are attached form a naphthyl; R 4 is H, F, Cl, Br, I, cyano, hydroxy, nitro, amino, COR b , COOR b , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, C 2-9 heterocyclyl, (phenyl)-C 1-6 alkylene, (C 2-9 heterocyclyl)-C 1-6 alkylene, or (C 3-7 cycloalkyl)-C 1-6 alkylene; wherein R b is H, C 1-6 alkyl, C 3-7 cycloalkyl, or (C 3-7 cycloalkyl)-C 1-6 alkylene; R 5 is H, F, Cl, Br, I, cyano, hydroxy, nitro, amino, C 1-6 alkyl, C 1-4 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, or C 3-7 cycloalkyl; R 6 is H, F, Cl, Br, I, cyano, hydroxy, nitro, amino, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, C 2-9 heterocyclyl, (phenyl)-C 1-6 alkylene, (C 2-9 heterocyclyl)-C 1-6 alkylene, or (C 3-7 cycloalkyl)-C 1-6 alkylene; X is NH, O, or CH 2 ; W is S, O, or ═N—CN; each of R 7 and R 8 is independently selected from H, C 1-6 alkyl, C 3-7 cycloalkyl, (C 3-7 cycloalkyl)-C 1-6 alkylene, phenyl, and (phenyl)-C 1-6 alkylene, provided at least one of R 7 and R 8 is not H; wherein each of the above hydrocarbyl or heterocarbyl moieties can be optionally substituted with between 1 and 3 substituents selected from F, Cl, Br, I, cyano, hydroxy, nitro, amino, COR c , COOR c , C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylthio, C 1-3 haloalkyl, and C 3-6 cycloalkyl; wherein R c is H or C 1-6 alkyl; provided when W is O, X is NH, and R 7 and R 8 are each methyl, and R 3 , R 4 , R 5 , and R 6 are each H, then R 2 is not H, 2-chlorophenyl, or 3-quinolinyl; and pharmaceutically acceptable salts, esters, amides, and hydrates thereof.