Patent ID: 6897291

Claim:
An isolated polypeptide monomer of a pH sensitive potassium channel, the monomer: (i) forming a potassium channel having a unit conductance of 80-120 pS and having increased potassium channel current amplitude above intracellular pH of 7.1, when the monomer is expressed in Xenopus oocyte; and (ii) encoded by a nucleic acid that specifically binds under stringent hybridization conditions to the complement of a nucleic acid encoding an amino acid sequence of SEQ ID NO:16 or SEQ ID NO:18, wherein the hybridization reaction is incubated at 42° C. in a buffer comprising 50% formamide, 5×SSC, and 1% SDS, and washed at 65° C. in a buffer comprising 0.2×SSC and 0.1% SDS.