Patent ID: 8871920

Claim:
An L-nucleic acid molecule that binds sphingosine 1-phosphate, wherein the L-nucleic acid molecule comprises in 5′→3′ direction, (a) a first terminal stretch of nucleotides, a central stretch of nucleotides and a second terminal stretch of nucleotides, or (b) the second terminal stretch of nucleotides, the central stretch of nucleotides and the first terminal stretch of nucleotides, wherein the first terminal stretch of nucleotides comprises three to six nucleotides, and the second terminal stretch of nucleotides comprises three to six nucleotides, and the central stretch of nucleotides comprises (SEQ ID NO: 43) 5′ AAUAGCCGUUGAAACGCCUUUAGAGAAGCACUAG 3′, (SEQ ID NO: 44) 5′ AAUAGCCGAUGAAACGCCUUUAGAGAAGCACUAG 3′ or (SEQ ID NO: 45) 5′ AAUAGCCGAAUGAAACGCCUUAAGAGAAGCACUAG 3′.