Patent ID: 8809377

Claim:
A compound having a formula (II) or (IIa): wherein R 1 is selected from the group consisting of —O(CH 2 ) m NEt 2 ; —O(CH 2 ) m NMe 2 ; —O(CH 2 ) m NHEt; —O(CH 2 ) m NHMe; —O(CH 2 ) m morpholinyl; —O(CH 2 ) m substituted morpholinyl; —O(CH 2 ) m sulfoxymorpholinyl; —O(CH 2 ) m substituted sulfoxymorpholinyl; —O(CH 2 ) m pyrrolidinyl; —O(CH 2 ) m substituted pyrrolidinyl; —O(CH 2 ) m piperazinyl; —O(CH 2 ) m substituted piperazinyl; —O(CH 2 ) m piperidinyl; —O(CH 2 ) m substituted piperidinyl; —O(CH 2 ) m N(Me)(CH 2 ) 2 NMe 2 ; —O(CH 2 ) m N(Me)(CH 2 ) 2 NHMe; —O(CH 2 ) m N(Me)(CH 2 ) 2 NEt 2 ; —O(CH 2 ) m N(Me)(CH 2 ) 2 NHEt; —O(CH 2 ) m O(CH 2 ) 2 NMe 2 ; —O(CH 2 ) m O(CH 2 ) 2 NHMe; —O(CH 2 ) m O(CH 2 ) 2 NEt 2 ; —O(CH 2 ) m O(CH 2 ) 2 NHEt, —O(CH 2 ) m O(CH 2 ) 2 heterocycloalkyl; and —O(CH 2 ) m O(CH 2 ) 2 substituted heterocycloalkyl; R 1A is selected from the group consisting of H, amido, substituted amido, halide, —(CH 2 ) m R 9 , —NH(CH 2 ) m R 9 , —NHC(O)(CH 2 ) m R 9 , —C(O)NH(CH 2 ) m R 9 and —O(CH 2 ) m R 9 ; X is fluoro or chloro; R 2 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, R 9 is amino, substituted amino, hydroxy, alkoxy, substituted alkoxy, cycloheteroalkyl, or substituted cycloheteroalkyl; and m is 2, 3, or 4, or a pharmaceutically acceptable salt thereof.