Patent ID: 8003627

Claim:
A compound having the formula (I) and stereoisomeric forms, racemic mixtures, prodrugs, pharmaceutically acceptable salts and N-oxides thereof, wherein R 3 is guanidino, optionally substituted with ethyl or methyl; wherein R 1 , R 2 , R 4 and R 5 are, each independently, chosen from the group consisting of hydrogen, halogen, perhaloalkyl, alkoxy, alkanoyl, alkanoyloxy, and alkoxycarbonyl; wherein A is methylene or ethylene; wherein R 6 is hydrogen or methyl; wherein X is chosen from the group consisting of hydrogen, C 1-6 alkyl, aryl, aralkyl, perhaloalkyl, formyl, alkanoyl, aroyl, aralkanoyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, carbamoyl, alkylcarbamoyl, arylcarbamoyl, aralkylcarbamoyl, alkylsulfinyl, arysulfinyl, aralkylsulfinyl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, aminosulfinyl and aminosulfonyl, optionally substituted with one or more substituents independently chosen from the group comprising or consisting of: halogen, perhaloalkyl, nitro, cyano, alkyl, aryl, aralkyl, hydroxyl, alkoxy, aryloxy, aralkoxy, —OC(═NR∝)R″, mercapto, alkylthio, arylthio, aralkylthio, —SC(═NR′)R″, formyl, alkanoyl, aroyl, aralkanoyl, formyloxy, alkanoyloxy, aroyloxy, aralkanoyloxy, carboxyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, carbamoyl and substituted carbamoyl, alkylcarbamoyl, arylcarbamoyl, aralkyl carbamoyl, formylamino, alkanoylamino, cycloalkylcarbonylamino, aroylamino, aralkanoylamino, sulfo and substituted sulfo, sulfonyl, aminosulfonyl, imino, —C(═NR′)OH, —C(═NR′)OR″, —C(═NR′)SH, —C(═NR′)SR″, oxo, primary amino, alkylamino, dialkylamino, arylamino, aralkylamino, —NR′C(═O)OR″, —NR′C(O)NR″R′″, —NR′C(S)NR″R′″, —N(OH)C(═O)OR′, —NR′C(═O)SR″, —N(OH)C(═O)NR′R″, —N(OH)C(S)NR′R″, —NR′C(O)N(OH)R″, —NR′C(S)N(OH)R″, —NR′S(═O) 2 R″, —NHS(═O) 2 NR′R″, —NR′S(═O) 2 NHR″, and —P(═O)(OR′)(OR″), wherein R′, R″ and R′″ each independently, selected from the group comprising or consisting of hydrogen, hydroxyl, alkyl, aryl, aralkyl, optionally substituted with one or more substituents independently chosen from the group comprising or consisting of halogen, hydroxyl, oxo, alkoxy, aryloxy, aralkoxy, alkanoyl, oxoalkyl, carboxyl, alkyloxycarbonyl, cyano and amino; wherein Z 1 and Z 2 is, each independently, chosen from the group consisting of aryl, wherein any Z 1 and Z 2 groups is, each independently, optionally substituted with one or more substituents independently chosen from the group comprising: halogen, perhaloalkyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkanoyl, aroyl, aralkanoyl, alkanoyloxy, aroyloxy, aralkanoyloxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, oxo, primary amino, alkylamino, dialkylamino, arylamino, and aralkylamine, alkanoylamino, cycloalkylcarbonylamino, aroylamino, and aralkanoylamino.