Patent ID: 7071338

Claim:
A method of preparing a bis-aryl diamidoxime compound of formula (I): wherein: R, R 1 , and R 2 are the same or different and are selected from the group consisting of H, aryl, linear alkyl, cyclic alkyl, and branched alkyl; Q is selected from the group consisting of O, S, NH and CH 2 ; and pharmaceutically acceptable salts thereof; the method comprising: (a) contacting an amidoxime aryl halide with a 2,5-bis trialkylstannane compound under an anhydrous gas to form a first reaction mixture, wherein the amidoxime aryl halide has the following structure: wherein R, R 1 , and R 2 are the same or different and are selected from the group consisting of H, aryl, linear alkyl, cyclic alkyl, and branched alkyl; and X is halogen; and wherein the 2,5-bis trialkylstannane has the following structure: wherein R 3 is lower alkyl and Q is selected from the group consisting of O, S, NH and CH 2 ; (b) adding an anhydrous aprotic solvent and a palladium catalyst to the first reaction mixture to form a second reaction mixture; and (c) refluxing the second reaction mixture for a period of time, whereby a bis-aryl diamidoxime compound of formula (I) is prepared.