Patent ID: 7659275

Claim:
A compound represented by the structural formula IA: or a pharmaceutically acceptable salt, or ester thereof; wherein: R 1 is selected from the group consisting of R 9 -phenyl, R 9 -pyridyl, R 9 -thiophenyl, R 9 -naphthyl, and R 2 is selected from the group consisting of H and alkyl; R 3 is selected from the group consisting of H, alkyl, alkoxyalkyl-, cycloalkyl, cycloalkylalkyl-, R 9 -aryl, R 9 -arylalkyl-, R 9 -heteroaryl, and R 9 -heteroarylalkyl-; or R 2 and R 3 together are ═O, ═N(OR 12 ), or ═N—N(R 13 )(R 14 ); R 4 , R 5 , R 6 and R 7 are independently selected from the group consisting of H and alkyl; R 8 is selected from the group consisting of R 9 is 1, 2 or 3 substituents independently selected from the group consisting of H, halogen, alkyl, alkoxy, —CF 3 , —OCF 3 , CH 3 C(O)—, —CN, CH 3 S(O 2 )—, CF 3 S(O 2 )—, —N(R 18 )(R 19 ); R 10 is selected from the group consisting of H and alkyl; R 11 is selected from the group consisting of H, alkyl, fluoroalkyl-, R 9 -arylalkyl-, R 9 -heteroaryl-, alkyl, alkyl-S(O 2 )—, cycloalkyl-S(O 2 )—, fluoroalkyl-S(O 2 )—, R 9 -aryl-S(O 2 )—, R 9 -heteroaryl-S(O 2 )—, N(R 18 )(R 19 )-S(O 2 )—, alkyl-C(O)—, cycloalkyl-C(O)—, fluoroalkyl-C(O)—, R 9 -aryl-C(O)—, alkyl-NH—C(O)—and R 9 -aryl-NH—C(O)—; R 12 is H, alkyl, fluoroalkyl-, cycloalkylalkyl-, hydroxyalkyl-, alkyl-O-alkyl-, alkyl-O—C(O)-alkyl- or N(R 18 )(R 19 )—C(O)-alkyl-; R 13 and R 14 are independently selected from the group consisting of H, alkyl and cycloalkyl, or R 13 and R 14 together are (C 2 -C 6 )alkylene and form a ring with the nitrogen atom to which they are shown attached; R 15 and R 16 are independently selected from the group consisting of alkyl, halogen, —NR 18 R 19 , —OH, —CF3, —OCH 3 , —O-acyl and —OCF 3 ; R 17 is R 20 O—; R 18 and R 19 are independently selected from the group consisting of H and alkyl; R 20 is selected from the group consisting of alkyl, haloalkyl cycloalkyl, heterocyclyl, aralkyl, alkylaryl, aryl, and heteroaryl; Q and Z are independently selected from the group consisting of CH and N; n is 0, 1, 2, 3 or 4; s is 0, 1, 2, 3 or 4; and t is 1, 2, 3 or 4; with the proviso that when n is 0, Z is CH.