Patent ID: 8278426

Claim:
A bicyclic nucleoside having Formula I: wherein: Bx is a heterocyclic base moiety; one of T 1 and T 2 is H or a hydroxyl protecting group and the other of T 1 and T 2 is H, a hydroxyl protecting group or a reactive phosphorus group; Q is C(q 1 )(q 2 )C(q 3 )(q 4 ), C(q 1 )=C(q 3 ), C[═C(q 1 )(q 2 )]-C(q 3 )(q 4 ) or C(q 1 )(q 2 )-C [═(q 3 )(q 4 )]; q 1 , q 2 , q 3 and q 4 are each, independently, H, halogen, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 1 -C 12 alkoxy, substituted C 1 -C 12 alkoxy, OJ 1 , SJ 1 , SOJ 1 , SO 2 J 1 , NJ 1 J 2 , N 3 , CN, C(═O)OJ 1 , C(═O)NJ 1 J 2 , C(═O)J 1 , O—C(═O)NJ 1 J 2 , N(H)C(═NH)NJ 1 J 2 , N(H)C(═O)NJ 1 J 2 or N(H)C(═S)NJ 1 J 2 ; wherein each substituted group is, independently, mono or poly substituted with substituent groups independently selected from halogen, OJ 1 , SJ 1 , NJ 1 J 2 , N 3 , CN, C(═O)OJ 1 , C(═O)NJ 1 J 2 , C(═O)J 1 , O—C(═O)NJ 1 J 2 , N(H)C(═O)NJ 1 J 2 or N(H)C(═S)NJ 1 J 2 ; each J 1 and J 2 is, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 aminoalkyl or a protecting group; and wherein when Q is C(q 1 )(q 2 )C(q 3 )(q 4 ) and one of q 3 or q 4 is CH 3 then at least one of the other of q 3 or q 4 or one of q 1 and q 2 is other than H.