Patent ID: 8748428

Claim:
A method for inhibiting the growth of B-cell lymphoma having chronic active B-cell-receptor signaling comprising administering to a patient in need of such treatment (i) a PKC inhibitor selected from the group consisting of sotrastaurin, 3-(1H-Indol-3-yl)-4-[2-(piperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione; 3-[2-chloro-7-[(dimethylamino)methyl]-1-naphthalenyl]-4-[7-[2-(2-methoxyethoxy)ethoxy]-1H-indol-3-yl]-1H-pyrrole-2,5-dione; 3-[3-(4,7-diaza-spiro[2,5]oct-7-yl)-isoquinolin-1-yl]-4-(7-methyl-1H-indol-3-yl)-pyrrole-2,5-dione; 3-[2-chloro-7-[(dimethylamino)methyl]-1-naphthalenyl]-4-[7-[2-(2-methoxyethoxy)ethoxy]-1H-indol-3-yl]-1H-pyrrole-2,5-dione; and (9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5, 21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione; and (ii) an mTOR inhibitor which is everolimus.