Patent ID: 8871927

Claim:
A process for refining Ceftizoxime sodium compound comprises the following steps: 1) dissolving crude Ceftizoxime sodium into water, extracting from several minutes to 10 hours with cyclohexane or ethyl acetate, then separating the organic phase that contains impurities and an aqueous phase that contains Ceftizoxime sodium; 2) adding ammonia or ammonium hydroxide into the aqueous phase of step 1), stirring from several minutes to 8 hours, filtrating the precipitate, yielding an aqueous filtrate that contains Ceftizoxime sodium, and optionally, removing the ammonia in the aqueous filtrate by heating; 3) adding an alcoholic solvent into the aqueous solution of step 2), and recrystallizing by adjusting the temperature, centrifuging, washing the resultant crystals, drying and yielding the refined Ceftizoxime sodium; 4) optionally, recycling the remaining liquid of step 3) for the recrystallization as step 3).