Patent ID: 7109186

Claim:
A compound of Formula I, or pharmaceutically acceptable salts or solvates thereof wherein: R 1 is -phenyl substituted with 1–3 R 4 , -naphthyl, furanyl, thienyl, pyridyl, or imidazolyl unsubtituted or substituted with 1–3 R 4 , —C 1 –C 6 alkyl-aryl unsubtituted or substituted with 1–3 R 4 , or —C 1 –C 5 alkyl-O-aryl unsubtituted or substituted with 1–3 R 4 ; R 2 is —H, —C 1 –C 6 alkyl, -aryl unsubstituted or substituted with 1–3 R 4 , or —C 1 –C 6 alkyl aryl unsubstituted or substituted with 1–3 R 4 ; R 3 is —H, —C 1 –C 6 alkyl, —C 1 –C 6 alkyl-aryl unsubstituted or substituted with 1–3 R, or —OR 9 ; R 4 is independently selected from -halo, —CN, —C 1 –C 6 alkyl, —C 3 –C 6 cycloalkyl, —C 1 –C 6 haloalkyl, —OR 5 , —CO 2 R 6 , —N(R 7 )(R 8 ), —CON(R 7 )(R 8 ), —SR 5 , —SOC 1 –C 6 alkyl, and —SO 2 C 1 –C 6 alkyl; R 5 and R 6 are independently selected from —H and —C 1 –C 6 alkyl; R 7 and R 8 are independently selected from —H and —C 1 –C 6 alkyl, or NR 7 R 8 is a heterocycle selected from pyrrolidine, piperidine, 4-hydroxypiperidine, morpholine, thiomorpholine, piperazine, and 4-methylpiperazine; R 9 is —H, —C 1 –C 10 alkyl, —C 1 –C 6 alkyl-aryl, —C 2 –C 10 alkyl-OR 5 , —C 1 –C 10 alkyl-CO 2 R 6 , —C 1 –C 10 alkyl-N(R 7 )(R 8 ), —C 1 –C 10 alkyl-CON(R 7 )(R 8 ), or —C 1 –C 6 alkyl-heterocycle where the heterocycle is selected from pyrrolidine, piperidine, 4-hydroxypiperidine, morpholine, thiomorpholine, piperazine, 4-methylpiperazine, and thiazinanedioxide; B 1 is selected from the group consisting of R 10 is —H, —C 1 –C 6 alkyl, -cycloalkyl, —C 1 –C 6 alkyl-aryl, -phenyl unsubstituted or substituted with 1–3 R 12 , benzofuran, dihydrobenzofuran, benzodioxane, or -heteroaryl selected from furan, thiophene, pyrrole, imidazole, oxazole, thiazole, and pyridine; R 11 is —C 1 –C 6 alkyl, -cycloalkyl, -aryl unsubstituted or substituted with 1–2 R 4 , —C 1 –C 6 alkyl-aryl unsubstituted or substituted with 1–2 R 4 , —C 1 –C 6 alkyl-heteroaryl where the heteroaryl is selected from furan, thiophene, pyrrole, imidazole, oxazole, thiazole, and pyridine, —C 1 –C 6 alkyl-NR 7 R 8 , —C 1 –C 6 alkyl-OR 5 , —C 1 –C 6 alkyl-P(O)(OR 6 ) 2 , —C 1 –C 6 alkyl-CO 2 R 6 , or —C 1 –C 6 alkyl-C(O)N(R 7 )(R 8 ); R 12 is halogen, —C 1 –C 6 alkyl, —C 1 –C 2 haloalkyl, —C 1 –C 3 thioalkyl, —OR 13 , tetrahydrofuran, dihydropyran, —NR 7 R 8 , —CO 2 R 6 , —CONR 7 R 8 , or —CONHCH 2 Ph where Ph is unsubstituted or substituted with 1–2 R 4 ; R 13 is —H, —C 1 –C 6 alkyl, —C 1 –C 6 fluoroalkyl, allyl, propargyl, phenyl, benzyl, —COC 1 –C 6 alkyl, —CH 2 CO 2 R 6 , or —CH 2 CONR 7 R 8 .