Patent ID: 7202244

Claim:
A compound of Formula III: or a pharmaceutically acceptable salt thereof, wherein: X 1 –X 3 are; X 4 is N; Z is O, S, or N—CN; Ring A is optionally substituted at any substitutable carbon by R 4 ; R 1 is —T—NH 2 , —V—T—NH 2 , —T—NHR x , or —V—T—NHR x ; T is a C 1-6 straight or branched alkylidene chain that is optionally interrupted by —O—, —S—, —N(R 5 )—, —S(O)—, —SO 2 —, —C(O)—, —OC(O)—, —N(R 5 )C(O)—, —C(O)N(R 5 )—, —SO 2 N(R 5 )—, or —N(R 5 )SO 2 —, wherein the alkylidene chain or a portion thereof is optionally part of a 3–6 membered ring system; V is —O—, —S—, —N(R 5 )—, —S(O)—, —SO 2 —, —C(O)—, —OC(O)—, —N(R 5 )C(O)—, —C(O)N(R 5 )—, —SO 2 N(R 5 )—, or —N(R 5 )SO 2 —; R 2 and R 3 are each independently selected from hydrogen, C 1-6 alkyl optionally substituted with —N(R 8 ) 2 , —C(═O)R, —CO 2 R, or SO 2 R, or R 2 and R 3 taken together with their intervening atoms form an optionally substituted an optionally substituted 5–6 membered ring; each R 4 is independently selected from halo, —OR, —SR, —CN, —NO 2 , —N(R 5 ) 2 , —N(R 5 )C(O)R, —N(R 5 )CO 2 R, —N(R 5 )C(O)N(R 5 ) 2 , —C(O)N(R 5 ) 2 , —C(O)R 5 , —OC(O)N(R 5 ) 2 , —CO 2 R, —SO 2 R, —S(O)R, —SO 2 N(R 5 ) 2 , —N(R 5 )SO 2 R, and an optionally substituted group selected from C 1-8 aliphatic, aryl, aralkyl, heterocyclyl, heterocycloalkyl, heteroaryl, and heteroaralkyl, or two ortho R 4 s, taken together with the ortho carbon atoms to which they are bonded, form an optionally substituted five or six membered phenyl, pyridyl or heterocyclyl fused to Ring A; each R 5 is independently selected from hydrogen, C 1-6 aliphatic, —CO 2 R, —SO 2 R, and —C(O)R, or two R 5 on the same nitrogen taken together with the nitrogen form a 5–8 membered heteroaryl or heterocycle ring having 1–4 heteroatoms selected from N, O, and S; each R 8 is independently a C 1-3 alkyl or, taken together with the nitrogen atom to which they are bonded, a 5–7 membered nitrogen containing heterocycle; Ring D is optionally substituted by C 1-4 aliphatic or haloaliphatic, —OR 7 , —SR 7 , —C(O)R 7 , —CO 2 R 7 , —SO 2 R 7 , —CN, —C(O)N(R 7 ) 2 , —N(R 7 )C(O)C 1-2 alkyl), or —N(R 7 ) 2 , and is optionally fused to an optionally substituted phenyl or optionally substituted cyclohexyl ring; each R 7 is independently selected from hydrogen or an optionally substituted C 1-3 aliphatic or —N(R 7 ) 2 is a nitrogen-containing heterocyclyl; each R is independently selected from hydrogen and an optionally substituted group selected from C 1-6 aliphatic, aryl, aralkyl, heteroaryl, and heteroaralkyl-butyl; and R x is C1–C8 alkyl.