Patent ID: 6919369

Claim:
A compound having the structure: wherein X is C═O or CH 2 ; R 1 is selected from C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, phenyl, naphthyl, benzyl and heteroaryl, wherein heteroaryl has 5 or 6 ring carbon atoms and 1 or 2 heteroatoms, where the heteroatoms are N, S, or O, and where the heteroaryl group is linked to the sulfonamide group by a carbon atom; and where R 1 is optionally substituted with 1-3 substituents selected from halo, nitro, C 1 -C 6 alkyl, NR 7 R 8 , OR 7 , SR 7 , C 1 -C 6 alkyl-C(O)OR 7 , C 1 -C 6 alkyl-OC(O)R 7 , C 1 -C 6 alkyl-C(O)R 7 , C 1 -C 6 alkyl-OR 7 , C 1 -C 6 haloalkyl, C 1 -C 6 alkyl-NR 7 R 8 , C(O)OR 7 , OC(O)R 7 , C(O)NR 7 R 8 , OC(O)NR 7 R 8 , NHC(O)R 7 , and NHC(O)NR 7 R 8 ; Q is phenyl optionally substituted with one or more groups selected from halo, nitro, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, NR 7 R 8 , OR 7 , SR 7, C 1 -C 6 alkyl-C(O)OR 7 , OC 1 -C 6 alkyl-C(O)OR 7 , C 1 -C 6 alkyl-OR 7 , OC 1 -C 6 alkyl-OR 7 , C 1 -C 6 alkyl-NR 7 R 8 , OC 1 -C 6 alkyl-NR 7 R 8 , C 1 -C 6 alkyl-C(O)NR 7 R 8 , OC 1 -C 6 alkyl-C(O)NR 7 R 8 , C 1 -C 6 alkyl-C(O)R 7, OC 1 -C 6 alkyl-C(O)R 7 , C 1 -C 6 haloalkyl, O-aralkyl, C(O)OR 7 , C(O)NR 7 R 8 , OC(O)NR 7 R 8 , NHC(O)R 7 , NHC(O)NR 7 R 8 , NR 7 S(O) 2 R 1 , NR 7 S(O) 2 R 7 , NR 7 S(O) 2 C 1 -C 6 alkyl-C(O)OR 7, S(O) 2 R 7 , and S(O) 2 NR 7 R 8 ; R 6 is selected from H, C 1 -C 6 alkyl, C 1 -C 6 alkyl-OR 7 , C 1 -C 6 alkyl-NR 7 R 8 , C 1 -C 6 haloalkyl, halo, cyano, OR 7 , SR 7 , NR 7 R 8 , C(O)OR 7 , C(O)R 7 and OC(O)R 7 ; and R 7 and R 8 are independently H, C 1 -C 6 alkyl, or phenyl; and acid and base addition salts thereof.