Patent ID: 8580257

Claim:
A method of treating ovarian cancer comprising cells expressing Kidney associated antigen 1 (KAAG1; SEQ ID NO.:2) in a subject, the method comprising administering an isolated antibody or antigen binding fragment thereof capable of binding to KAAG1 to the subject wherein the antibody or antigen binding fragment thereof is selected from the group consisting of antibodies and antigen binding fragment thereof comprising: a. A heavy chain variable region comprising a CDRH3 having the sequence of SEQ ID NO.: 32, a CDRH1 having the sequence of SEQ ID NO.: 30 and a CDRH2 having the sequence of SEQ ID NO.:31 and a light chain variable region comprising a CDRL3 having the sequence of SEQ ID NO.:29, a CDRL1 having the sequence of SEQ ID NO.:27 and a CDRL2 having the sequence of SEQ ID NO.:28; b. A heavy chain variable region comprising the sequence set forth in SEQ ID NO.:18 and a light chain variable region comprising the sequence set forth in SEQ ID NO.:16; c. A heavy chain comprising the sequence set forth in SEQ ID NO.:6 and a light chain comprising the sequence set forth in SEQ ID NO.:4; d. A heavy chain variable region comprising the sequence set forth in SEQ ID NO.:179 and a light chain variable region comprising the sequence set forth in SEQ ID NO.:178; e. A heavy chain comprising the sequence set forth in SEQ ID NO.:177 and a light chain comprising the sequence set forth in SEQ ID NO.:176; f. A heavy chain variable region comprising a CDRH3 having the sequence of SEQ ID NO.: 38, a CDRH1 having the sequence of SEQ ID NO.: 36 and a CDRH2 having the sequence of SEQ ID NO.:37 and a light chain variable region comprising a CDRL3 having the sequence of SEQ ID NO.:35, a CDRL1 having the sequence of SEQ ID NO.:33 and a CDRL2 having the sequence of SEQ ID NO.:34; g. A heavy chain variable region comprising the sequence set forth in SEQ ID NO.:22 and a light chain variable region comprising the sequence set forth in SEQ ID NO.:20; and; h. A heavy chain comprising the sequence as set forth in SEQ ID NO.:10 and a light chain comprising the sequence as set forth in SEQ ID NO.:8.