Patent ID: 8592583

Claim:
A process for preparing a 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamide of the formula (I): wherein R1 and R2 independently represent hydrogen, halogen, C 1 -C 6 alkyl, (C 1 -C 6 ) alkoxy, cycloalkyl, aryl or nitro group, which process comprises: a) coupling an acetal of formula (II): wherein R3 is C 1 -C 6 alkyl and both R4 are independently C 1 -C 6 alkyl or taken together are an alkylene chain having 2 or 3 carbon atoms and forming a cyclic acetal, with a beta-ketoester or a salt thereof of formula (III): wherein R5 is C 1 -C 6 alkyl, first under acidic conditions and then under nucleophilic conditions; b) acetylating the resultant compound of the formula (IV): with an acetyl halide or acetic anhydride in the presence of a Lewis acid; c) reacting the resultant compound of formula (V): with a C 1 -C 6 dialkyl acetal of N,N-dimethyl formamide; d) reacting the resultant enaminone of formula (VI): with guanidine or a salt thereof; e) hydrolyzing the carboxylic ester group of the resultant compound of formula (VII): f) condensing the carboxylic acid group of the resultant compound of formula (VIII): with a form of ammonia, to give the carboxamide of formula (I); and, optionally, converting it into a pharmaceutically acceptable salt.