Patent ID: 7179802

Claim:
A compound represented by Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: A and B may be taken separately or together; when taken separately, A represents halo, C 1-6 alkyl, OC 1-6 alkyl or phenyl, said alkyl, phenyl and the alkyl portion of OC 1-6 alkyl being optionally substituted with 1–3 halo groups; and B represents represents H, halo, C 1-6 alkyl, —OC 1-6 alkyl, —SC 1-6 alkyl, C 2-6 alkenyl, phenyl or naphthyl, said alkyl, alkenyl, phenyl, naphthyl, and the alkyl portions of —OC 1-6 alkyl and —SC 1-6 alkyl being optionally substituted with 1–3 groups selected from halo, OH, CH 3 O, CF 3 and OCF 3 ; and when taken together, A and B together represents (a) C 1-4 alkylene optionally substituted with 1–3 halo groups, and 1–2 R a groups wherein R a represents C 1-3 alkyl, OC 1-3 alkyl, C 6-10 arC 1-6 alkylene or phenyl optionally substituted with 1–3 halo groups, or (b) C 2-5 alkanediyl such that they form a 3–6 membered ring with the carbon atom to which they are attached, said ring optionally containing 1 double bond or 1–2 heteroatoms selected from O, S and N, said 3–6 membered ring being optionally substituted with C 1-4 alkylene, oxo, ethylenedioxy or propylenedioxy, and being further optionally substituted with 1–4 groups selected from halo, C 1-4 alkyl, haloC 1-4 alkyl, C 1-3 acyl, C 1-3 acyloxy, C 1-3 alkoxy, C 1-6 alkylOC(O)—, C 2-4 alkenyl, C 2-4 alkynyl, C 1-3 alkoxyC 1-3 alkyl, C 1-3 alkoxyC 1-3 alkoxy, phenyl, CN, OH, D, NH 2 , NHR a and N(R a ) 2 wherein R a is as previously defined; each R 1 represents H or is independently selected from the group consisting of: OH, halo, C 1-10 alkyl, C 1-6 alkoxy and C 6-10 aryl, said C 1-10 alkyl, C 6-10 aryl and the alkyl portion of C 1-6 alkoxy being optionally substituted with 1–3 halo, OH, OC 1-3 alkyl, phenyl or naphthyl groups, said phenyl and naphthyl being optionally substituted with 1–3 substituents independently selected from halo, OCH 3 , OCF 3 , CH 3 , CF 3 and phenyl, wherein said phenyl is optionally substituted with 1–3 halo groups, or two R 1 groups taken together represent a fused C 5-6 alkyl or aryl ring, which may be optionally substituted with 1–2 OH or R a groups, wherein R a is as defined above; R 2 and R 3 are taken together; and represent (a) a C 3-8 alkanediyl forming a fused 5–10 membered non-aromatic ring optionally interrupted with 1–2 double bonds, and optionally containing 1–2 heteroatoms selected from O, S and N; or (b) a fused 6–10 membered aromatic monocyclic or bicyclic group, said alkanediyl and aromatic monocyclic or bicyclic group being optionally substituted with 1–6 halo atoms, and 1–4 of OH, C 1-3 alkyl, OC 1-3 alkyl, haloC 1-3 alkyl, haloC 1-3 alkoxy, and phenyl, said phenyl being optionally substituted with 1–4 groups independently selected from halo, C 1-3 alkyl, OC 1-3 alkyl , and said C 1-3 alkyl and the C 1-3 alkyl portion of OC 1-3 alkyl being optionally substituted with 1–3 halo groups.