Patent ID: 7875624

Claim:
A method of reducing cellular adhesion in a cancer patient, comprising: administering to the cancer patient a compound of Structure II, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable salt of the tautomer, or a mixture thereof, and measuring the amount of at least one of inducible cell adhesion molecule, vascular cell adhesion molecule, or endothelial leukocyte adhesion molecule in at least a portion of a blood sample withdrawn from the cancer patient after administration of the compound, the tautomer, the pharmaceutically acceptable salt of the compound, the pharmaceutically acceptable salt of the tautomer, or the mixture thereof, wherein cellular adhesion and the levels of circulating adhesion molecules are reduced in the cancer patient after administration, and Structure II has the following formula: wherein, A is a group having one of the following Structures: wherein, R a is selected from H or straight or branched chain alkyl groups having from 1 to 6 carbon atoms.