Patent ID: 8461384

Claim:
A process for the preparation of an amide corresponding to Formula 502, the process comprising treating an acid corresponding to Formula 301 with an amine corresponding to Formula 400 under anhydrous conditions and at a temperature of from about 25° C. to about 100° C. to form the amide corresponding to Formula 502: wherein R 1 and R 7 are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or —OR 111 ; R 2 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 211 ; R 3 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or —OR 311; R 4 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 411 ; R 5 and R 6 are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or —OR 511 ; R 12 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 121 ; R 13 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 511 ; R 111 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; R 211 is hydrogen, hydrocarbyl, —C(O)R 212 , —C(O)NHR 213 , or SO 2 R 214 ; R 212 , R 213 , and R 214 are independently hydrocarbyl or substituted hydrocarbyl; R 311 is hydrogen, hydrocarbyl, —C(O)R 312 , —C(O)NHR 313 , or —SO 2 R 314 : R 312 is alkyl or aryl, provided, R 312 is other than methyl or phenyl; R 313 is hydrocarbyl or substituted hydrocarbyl; R 314 is alkyl or aryl, provided, R 314 is other than methyl; R 411 is hydrogen, hydrocarbyl, —C(O)R 412 , —C(O)NHR 413 , or —SO 2 R 414 ; R 412 is alkyl or aryl, provided, R 412 is other than methyl or phenyl; R 413 and R 414 are independently hydrocarbyl or substituted hydrocarbyl; R 511 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; and R 121 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; wherein at least one of R 2 , R 3 , or R 4 is —OC(O)R 212 , —OC(O)NHR 213 , —OSO 2 R 214 , —OC(O)R 312 , —OC(O)NHR 313 , —OSO 2 R 314 , —OC(O)R 412 , —OC(O)NHR 413 , or —OSO 2 R 414 .