Patent ID: 7521473

Claim:
A compound of formula (I), wherein R 1 is C(O)OR 5 , C(O)R 5 , or C(O)NR 5 R 6 ; R 2 is R 5 ; X is —O—C 1-3 alkylene, —NR 8 —C 1-3 alkylene, —S—C 1-3 alkylene, —SO—C 1-3 alkylene-, —SO 2 —C 1-3 alkylene, —C 1-4 alkylene, —C 2-4 alkenylene, —C 2-4 alkynylene-; wherein any of the alkylene, alkenylene or alkynylene groups is optionally substituted with one or more halogen, oxo, imido, CN, OCF 3 , OH, NH 2 , NO 2 , or Q; Y is absent, —O—, or —NR 6 —; R 3 is H, halogen, CN, CFR 3 , OCF 3 , C 1-3 alkyl, C 3-4 cycloalkyl, C 1-3 alkoxy, or aryl; R 4 is A-B-E-D, where A is arylene or heteroarylene, each A being optionally substituted with one or more of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halogen, CN, OCF 3 , OH, NH 2 , CHO, NO 2 , or Q; where any of the alkyl, alkenyl or alkynyl is optionally substituted with one or more halogen, oxo, CN, OCF 3 , OH, NH 2 , NO 2 , N 3 , or Q; B is absent or —NR 5 —, —NR 7 —, —N(R 5 )CH 2 —, —N(R 9 )—, —N(R 9 )C(O)—, —N(R 9 )C(O)C(R 11 )(R 12 )—, N(R 9 )C(O)C(O)—, —N(R 9 )C(O)N(R 10 )—, —N(R 9 )SO 2 —, —N(R 9 )SO 2 C(R 10 )(R 11 )—, —N(R 9 )(R 10 )C(R 11 )(R 12 )—, —N(R 9 )C(R 11 )(R 12 )C(R 13 )(R 14 )—, —O—, —O—C(R 11 )(R 12 ), —O—C(R 11 )(R 12 )C(R 13 )(R 14 )—, —C(R 11 )(R 12 )—O—, —C(R 11 )(R 12 )—O—C(R 13 )(R 14 )—, —C(R 11 )(R 12 )N(R 9 )—, —C(R 11 )(R 12 )N(R 9 C(R 13 )(R 14 )—, —C(R 11 )(R 12 )S—, —C(R 11 )(R 12 )SC(R 13 )(R 14 )—, or —C(R 11 )(R 12 )SO 2 C(R 13 )(R 14 )—; E is absent or C 3-12 cycloalkylene, 3- to 12-membered heterocycdiyl, arylene, C 1-12 alkylene, C 2-12 alkenylene, or C 2-12 alkynylene, where each E is optionally substituted with one or more C 1-3 alkyl, C 1-3 alkoxy, halogen, CN, OH, NH 2 , or NO 2 ; D is one or more H, halogen, OH, NH 2 , CHO, CN, NO 2 , CF 3 , or Q; each Q, independently, is —R 5 , —R 7 , —OR 5 , —OR 7 , —NR 5 R 6 , —NR 5 R 7 , —N + R 5 R 6 R 8 , S(O) n R 5 , or —S(O) n R 7 , where n is 0, 1, or 2; each R 5 , R 6 , and R 8 , independently, is H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 3-12 cycloalkyl, C 1-12 alkoxyC 1-12 alkyl, cycloalkylC 1-6 alkyl, 3- to 8-membered heterocycyl, heterocycylC 1-6 alkyl, aryl, arylC 1-6 alkyl, arylC 2-6 alkenyl, or arylC 2-6 alkynyl, where each R 5 , R 6 , and R 8 is optionally substituted with one or more R 9 , —OR 9 , —OC(O)OR 9 , —C(O)R 9 , —C(O)OR 9 , —C(O)NR 9 R 10 , —SR 9 , —S(O)R 9 , —S(O) 2 R 9 , —NR 9 R 10 , —N + R 9 R 10 R 11 , —NR 9 C(O)R 10 , —NC(O)NR 9 R 10 , —NR 9 S(O) 2 R 10 , oxo, halogen, CN, OCF 3 , CF 3 , OH, or NO 2 ; R 7 is —C(O)R 5 , —C(O)OR 5 , —C(O)NR 5 R 6 , —S(O) 2 R 5 , —S(O)R 5 , or —S(O) 2 NR 5 R 6 ; and each R 9 , R 10 , R 11 , R 12 , R 13 and R 14 is, independently, H, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 3-12 cycloalkyl, aryl, or arylC 1-12 alkyl; where any of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or arylalkyl, groups is optionally substituted with one or more halogen, oxo, CN, OCF 3 , OH, NH 2 , or NO 2 ; or a salt thereof.