Patent ID: 8541586

Claim:
A compound of formula: wherein R is —CH 3 , —CH 2 CH 2 CH(OH)C 6 H 11 , —CH 2 CH(CH 2 Ph)CONHCH 2 CO 2 H, —(CH— 2 ) 3 CH(CH 3 ) 2 or —(CH 2 ) 3 -2-thienyl; wherein Q is wherein is an aryl or heteroaryl residue of one to three rings; A is (CH 2 )n, wherein one or more CH 2 may be replaced by —O—, cycloalkyl or CR 1a R 1b ; R 1a and R 1b are chosen independently from hydrogen, halogen, lower alkyl, lower alkoxy and lower alkylthio; R 10 is one or two residues chosen independently from hydrogen, hydroxyl, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl and halo(C 1 -C 6 )alkoxy and (C 1 -C 6 )alkylthio; R 11 is H or is an aryl or heteroaryl residue of one to three rings; A′ is (CH 2 ) m wherein one or more CH 2 may be replaced by —O—, cycloalkyl, —CR 1a R 1b , —C(═O)— or —NH—; R 12 is chosen from hydrogen and lower alkyl; R 15 is one or two residues chosen independently from hydrogen, hydroxyl, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl and halo(C 1 -C 6 )alkoxy and (C 1 -C 6 )alkylthio; m is zero or an integer from 1 to 6; and n is an integer from 1 to 6; with the proviso that A is other than CH 2 .