Patent ID: 7658935

Claim:
A method for inhibiting the growth or proliferation of glioma cancer cells in a subject suffering from glioma wherein said glioma cancer cells express malignin, said method comprising administering to said subject an effective amount of a first dosage of a composition comprising malignin wherein said administration of said dosage stimulates the immune system of said subject to produce and release antimalignin antibody that binds and inhibits said glioma cancer cells and wherein said malignin is a polypeptide of approximately 10,000 Daltons isolated from glioma cancer cells and wherein said polypeptide has an amino acid composition of about 9 aspartic acid residues, about 5 threonine residues, about 5 serine residues, about 13 glutamic acid residues, about 4 proline residues, about 6 glycine residues, about 7 alanine residues, about 6 valine residues, about ½ of a cysteine residue, about 2 methionine residues, about 4 isoleucine residues, about 8 leucine residues, about 3 tyrosine residues, about 3 phenylalanine residues, about 6 lysine residues, about 2 histidine residues, and about 5 arginine residues and wherein said malignin elutes at a discreet spot of approximately 0.91±0.02 with reference to a standard of cytochrome C on a thin layer chromatogram when chromatographed on a plate of superfine SEPHADEX G-200 with a mobile phase of 0.5 M NaCl in 0.02 M Na 2 HPO 4 KH 2 PO 4 phosphate buffer having a pH between 6.6 and 7.0.