Patent ID: 7608740

Claim:
A process for preparing 2-amino-5-hydroxypropiophenone to synthesize camptothecin analogs, wherein compound (13) is produced by dropping a Grignard reagent under an inert atmosphere to compound (12) wherein compound (14) is produced by mixing compound (13) with an oxidizing agent and stirring the mixture in a solvent; wherein compound (15) is produced by dropping a nitrating agent to compound (14); wherein compound (16) is produced by mixing compound (15), a metal hydroxide and an alcohol, and stirring the mixture; wherein compound (17) is produced by deprotection of compound (16), or by stirring a mixture of compound (15) and an aqueous base; wherein compound (11) is produced by reduction of compound (17) by mixing with a base and a reducing agent, and stirring the mixture in an aqueous alcoholic solution; and wherein X is a halogen, and R is hydrogen or a protective group which can be deprotected.