Patent ID: 8344003

Claim:
A compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein X 1 represents N, S or O, or a divalent saturated hydrocarbon group of 1 to 6 carbon atoms (when the carbon number of the divalent saturated hydrocarbon group is 2 or more, one of the carbon atoms therein may be replaced by a nitrogen atom, oxygen atom or sulfur atom); R 1 represents a 6- to 10-membered aryl group, a cycloalkyl group of 3 to 7 carbon atoms, or lower alkyl group (wherein R 1 may be substituted on R 1 by 1 or 2 groups selected from the group consisting of amino group, lower alkyl group (the hydrogen atom of the lower alkyl group may be substituted by hydroxy group, lower alkoxy group, halogen atom, carbamoyl group, mono- or di-lower alkyl carbamoyl group, carboxyl group, alkoxy carboyl group, alkanoyl group, amino group, mono- or di-lower alkylamino group), lower alkoxy group (the hydrogen atom of the methylene group or methyl group constituting the lower alkoxy group may be substituted by hydroxyl group, halogen atom, carbamoyl group, mono- or di-loweralkyl carbamoyl group, carboxyl group, alkoxy carboyl group, alkanoyl group, amino group, mono- or di-lower alkylamino group), carbamoyl group, lower alkylcarbamoyl group, di-lower alkylcarbamoyl group, carbamoylamino group, carbamoyloxy group, carboxyl group, cyano group, sulfamoyl group, trifluoromethyl group, halogen atom group, hydroxy group, formyl group, C 2 -C 6 alkanoyl group, N—C 2 -C 6 alkanoylamino group, C 1 -C 6 alkylthio group, N—C 1 -C 6 alkylsulfamoyl group, N,N-di-C 1 -C 6 alkylsulfamoyl group, C 1 -C 6 alkylsulfinyl group, C 1 -C 6 alkylsulfonyl group, N—C 1 -C 6 alkylsulfonylamino group, C 1 -C 6 alkoxycarbonyl group, N—C 1 -C 6 alkylamino group and N,N-di-C 1 -C 6 alkylamino group); D represents O or S; R 2 and R 3 are the same or different, each representing a hydrogen atom, lower alkyl group, lower alkoxy group or halogen atom; the formula (II): represents a 1,2,4-triazolyl group, which may have on the ring 1 or 2 groups selected from the group consisting of lower alkyl group, lower alkoxy group, trifluoromethyl group, hydroxy group, hydroxyalkyl group (the hydrogen atom of the hydroxy group of the hydroxyalkyl group may further be substituted by a lower alkyl group) and halogen atom; the formula (III): represents a 1,2,4-thiadiazolyl group, that may optionally have 1 or 2 substituents selected from the group consisting of lower alkyl group, lower alkoxy group, halogen atom, trifluoromethyl group, hydroxyalkyl group (the hydrogen atom of the hydroxy group in the hydroxyalkyl group may further be substituted by a lower alkyl group), aminoalkyl group (the amino may be substituted by a lower alkyl group), alkanoyl group, carboxyl group, alkoxycarbonyl group and cyano group).