Patent ID: 8404649

Claim:
A compound of Formula (1) wherein R 1a , R 1b , and R 1c are each independently selected from hydrogen, halo, cyano, C 1− C 6 alkyl, C 1− C 6 haloalkyl, C 1− C 6 alkoxy, C 0− C 6 alkyl C 3− C 6 cycloalkyl, and C 1− C 6 haloalkoxy; R 2 is H, C 1− C 6 alkyl, C 0− C 6 alkyl phenyl, C 0− C 6 alkyl heteroaryl, C 0− C 6 alkyl C 3− C 6 cycloalkyl, or C 0− C 6 alkyl heterocycle; R 3 is H, C 1− C 6 alkyl, C 0− C 6 alkyl C 3− C 6 cycloalkyl, C 2− C 6 alkenyl, C 0− C 6 alkyl phenyl, C 1− C 4 alkyl-O-phenyl, C 0− C 6 alkyl heterocycle, or C 0− C 6 alkyl heteroaryl; each of R 2 and R 3 C 1− C 6 alkyl or C 0− C 6 alkylC 3− C 6 cycloalkyl can be optionally and independently substituted by at least one substituent selected from cyano, halo, hydroxyl, oxo, C 1− C 6 alkoxy, C 1− C 6 haloalkoxy, C 1− C 6 haloalkyl, —S(O) p R c , —SH, —S(O) p NR a R b , —NR a R b , —NR a C(O)R b , —SC(O)R c , —SCN, or —C(O)NR a R b ; and wherein R 2 and R 3 C 0− C 6 alkyl phenyl, C 0− C 6 alkyl heteroaryl, or C 0− C 6 alkyl heterocycle moiety can be further optionally substituted with at least one substituent selected from cyano, halo, oxo, ═S, ═NR d , hydroxyl, C 1− C 6 alkoxy, C 1− C 6 alkyl, C 1− C 6 haloalkyl, —SH, —S(O) p R, C 1− C 6 haloalkoxy, Het, and phenyl; R is C 1− C 6 alkyl or C 3− C 6 cycloalkyl each optionally substituted by at least one halo; R a is hydrogen, C 1− C 6 alkyl, or C 0− C 3 alkylC 3− C 6 cycloalkyl; wherein the alkyl and alkylcycloalkyl is optionally substituted by cyano or at least one halo substituent; R b is hydrogen, C 1− C 6 alkyl, C 3− C 6 cycloalkyl, C 0− C 3 alkylphenyl, C 0− C 3 alkylheteroaryl, or C 0− C 3 alkylheterocycle, each optionally substituted, where chemically possible, with at least one substituent selected from hydroxyl, cyano, halo, or —S(O) p R; or wherein R a and R b , with the N atom to which they are attached can form a 4-7 membered ring which may optionally include at least one additional heteroatom selected from N, O, and S; R c is C 1− C 6 alkyl, C 1− C 6 haloalkyl, C 1− C 6 haloalkylC 3− C 6 cycloalkyl, C 0− C 3 alkylC 3− C 6 cycloalkyl, C 0− C 3 alkylphenyl, C 0− C 3 alkylheteroaryl, or C 0− C 3 alkylheterocycle each optionally substituted with at least one substituent selected from cyano, halo, hydroxyl, oxo, C 1− C 6 alkoxy, C 1− C 6 haloalkoxy, C 1− C 6 haloalkyl, —S(O) p R, —SH, —S(O) p NR a R b , —NR a R b , —NR a C(O)R b , —SC(O)R b , —SCN, or —C(O)NR a R b ; R d is hydrogen, C 1− C 6 alkyl, hydroxyl, cyano, nitro, —S(O) p R c , or C 1− C 6 alkoxy; p is the integer 0, 1, or 2; and is a bond that represents E and Z geometric isomers; stereoisomers thereof, and pharmaceutically or veterinarily acceptable salts thereof.