Patent ID: 7087615

Claim:
A pharmaceutical composition comprising: a) an effective amount of one or more bicyclic pyrazolones including all enantiomeric and diastereomeric forms and pharmaceutically acceptable salts thereof, said compound having the formula: wherein R is: a) —O[CH 2 ] k R 3 ; or b) —NR 4a R 4b ; R 3 is substituted or unsubstituted C 1 –C 4 alkyl, substituted or unsubstituted hydrocarbyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl or alkylenearyl, substituted or unsubstituted heteroaryl or alkyleneheteroaryl; the index k is from 0 to 5; R 4a and R 4b are each independently: a) hydrogen; or b) —[C(R 5a R 5b )] m R 6 ; each R 5a and R 5b are independently hydrogen, or C 1 –C 4 linear, branched, or cyclic alkyl, and mixtures thereof; R 6 is hydrogen, —OR 7 , —N(R 7 ) 2 , —CO 2 R 7 , −CON(R 7 ) 2 ; substituted or unsubstituted C 1 –C 4 alkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7 is hydrogen, a water-soluble cation, C 1 –C 4 alkyl, or substituted or unsubstituted aryl; the index m is from 0 to 5; R 1 is: a) substituted or unsubstituted aryl; or b) substituted or unsubstituted heteroaryl; each R 2 unit is independently selected from the group consisting of: a) hydrogen; b) —(CH 2 ) j O(CH 2 ) n R 8 ; c) —(CH 2 ) j NR 9a R 9b ; d) —(CH 2 ) j CO 2 R 10 ; e) —(CH 2 ) j OCO 2 R 10 ; f) —(CH 2 ) j CON(R 10 ) 2 ; g) —(CH 2 ) j OCON(R 10 ) 2 ; h) two R 2 units can be taken together to form a carbonyl unit; i) and mixtures thereof; R 8 , R 9a , R 9b , and R 10 are each independently hydrogen, C 1 –C 4 alkyl, and mixtures thereof; R 9a and R 9b can be taken together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; two R 10 units can be taken together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; j is an index from 0 to 5, n is an index from 0 to 5; Z is O, S, NR 11 , or NOR 11 ; R 11 is hydrogen or C 1 –C 4 alkyl; b) an effective amount of one or more compounds having pain relief properties; and b) one or more pharmaceutically acceptable excipients.