Patent ID: 8877172

Claim:
A zwitterionic polymer bioconjugate comprising one or more zwitterionic polymers covalently coupled to a biomolecule, wherein the zwitterionic polymer comprises a plurality of repeating units, each repeating unit having the formula: wherein R 1 is selected from the group consisting of hydrogen, fluorine, trifluoromethyl, C1-C6 alkyl, and C6-C12 aryl groups; R 2 and R 3 are independently selected from the group consisting of alkyl and aryl, and taken together with the nitrogen to which they are attached form a cationic center; L 1 is a linker that covalently couples the cationic center [N + (R 2 )(R 3 )] to the polymer backbone [—(CH 2 —CR 1 ) n —]; L 2 is a linker that covalently couples the anionic center [A(=O)O − ] to the cationic center; A is C; M + is a counterion associated with the (A=O)O − anionic center; X − is a counter ion associated with the cationic center; n is an integer from 1 to about 10,000; and the biomolecule is a protein, a nucleic acid, a glycoprotein, a proteoglycan, or a lipid.