Patent ID: 7834024

Claim:
A method of inhibiting an activity of a JAK kinase, comprising contacting the JAK kinase with an amount of a compound effective to inhibit an activity of the JAK kinase wherein the compound is a compound of formula IA: or therapeutically acceptable salt thereof, wherein: q is 0, 1, 2 or 3; p is 1; R is hydrogen; X is fluoro; Y is a covalent bond and; alk is a covalent bond; R 1 is —C(O)NR 4 R 5 ; each R 2 independently is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryl, substituted aryl, aryloxy, substituted aryloxy, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, carboxyl, carboxyl ester, alkynyl, substituted alkynyl, hydroxyl, acyl, oxo, halo, acylamino, aminocarbonyl, and cyano; R 3 is 4-(1-methylpiperazin-4-yl); and R 4 and R 5 independently are selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, cycloalkyl, substituted cycloalkyl, and acyl; or R 4 and R 5 together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic.