Patent ID: 7557118

Claim:
A compound of Formula (Ia): prepared by a method comprising the step of cyclizing an azomethine ylide of general Formula (IIa): wherein R 1 -R 8 , R 14 and Y may be the same or different and each are selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally protected hydroxy, optionally substituted amino, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkynoxy, optionally substituted aryl, optionally substituted heterocyclyl, carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, optionally substituted alkylthio, halogen, nitro, sulfate, phosphate and cyano; Z is CH 2 , NH, or O; and n is selected from 0, 1, 2 or 3; wherein when n is 1, Z is CH 2 , or NH; and when n is 2 or 3, Z is selected from the group consisting of CH 2, NH and O, wherein at least one of Z is CH 2 ; and when n is 3, heteroatoms cannot be adjacent to each other.