Patent ID: 7153833

Claim:
A method for treating or reducing the severity of a disease or disorder mediated by a membrane metalloproteinase comprising: administering to a subject in need thereof an amount of a SMR-1 (submandibular rat 1 protein) peptide sufficient to modulate the activity of a metalloproteinase, wherein the SMR1-peptide comprises a sequence shown by formula (1): X 1 QHX 2 X 3 X 4 (SEQ ID NO: 11) wherein X 1 is absent from formula (1) or is selected from the group consisting of R, G, RR, PRR, GPRR, RGPRR and VRGPRR, X 2 is N, G or D, X 3 is P or L and X 4 is R or T.