Patent ID: 7273864

Claim:
A compound of formula I: wherein: R 1 is a member selected from the group consisting of hydrogen, halogen and —L—R 2 ; L is a member selected from the group consisting of —O— and —NR 3 —, wherein R 3 is H, or R 3 is optionally taken together with R 2 and the nitrogen to which both are attached to form a heterocycloalkyl, optionally substituted with C 1-4 alkyl; R 2 is a member selected from the group consisting of C 1-4 alkyl, and aryl-C 0-2 alkyl, substituted with 0-2 R 2a groups that are independently selected from the group consisting of halogen, C 1-4 alkyl, C 1-4 alkoxy, —N(R 2b R 2b ), —SO 2 N(R 2b R 2b ), —C(O)N(R 2b R 2b ) and —O-aryl, or when said R 2a groups are on adjacent ring atoms they are optionally taken together to form a member selected from the group consisting of —O—(CH 2 ) 1-2 —O—, —O—C(CH 3 ) 2 CH 2 — and —(CH 2 ) 3-4 —; each R 2b group is a member that is independently selected from the group consisting of hydrogen and C 1-4 alkyl; R 4 is a member selected from the group consisting of C 1-4 alkyl, C 3-8 cycloalkyl, hydroxy-C 1-4 alkyl, aryl-C 0-3 alkyl, substituted with 0-2 R 4a groups, cyclohexylmethyl and optionally substituted with C 1-4 alkyl; each R 4a group is a member independently selected from the group consisting of hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, and aryl, or when said R 4a groups are on adjacent ring atoms they are optionally taken together to form —O—(CH 2 ) 1-2 —O—; R 5 is hydrogen and R 6 is —N(R 7 R 8 ), or when R 5 and R 6 are on adjacent ring atoms they are optionally taken together to form —O—(CH 2 ) 1-2 —O—; R 7a and R 8 are taken together with the nitrogen to which they are attached to form a heterocycloalkyl, optionally substituted with C 1-4 alkyl; and all pharmaceutically acceptable salts and hydrates thereof.