Patent ID: 8026261

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, selected from the group consisting of: (a) a compound of formula (II): (b) a compound of formula (III): (c) a compound of formula (IIIC): and (d) a compound of formula (IV): wherein in formula I: Y is O or NR 1 , R 1 is selected from the group consisting of: hydrogen, C 1 -C 6 alkyl, cyclopropylmethyl, allyl and cyclopropyl: R 2 is selected from the group consisting of: hydrogen, C 1 -C 6 alkyl, CHF 2 , CH 2 CF 3 , CF 3 CHOH and R 5 CHOH, R 5 is selected from the group consisting of: hydrogen, C 1 -C 6 alkyl and trifluoromethyl; R 3 is selected from the group consisting of: methyl, hydrogen, CF 3 CHOH, C 1 -C 6 alkyl, CH 2 CF 3 , and CH(OCH 3 )CF 3 ; and R 4 is selected from the group consisting of: CHF 2 , methyl, hydrogen, C 1 -C 6 alkyl, CH 2 CF 3 , and CF 3 CHOH; provided that (a) when the compound of formula (I) is a compound of formula (II), then Y is NR 1 , wherein R 1 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, cyclopropylmethyl, allyl and cyclopropyl; R 2 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, and R 5 CHOH wherein R 5 is selected from the group consisting of hydrogen, C 1 -C 3 alkyl and trifluoromethyl; R 3 is selected from the group consisting of methyl, hydrogen and CF 3 CHOH; and R 4 is CHF 2 ; and (b) when the compound of formula (I) is a compound of formula (III), then: Y is NR 1 , wherein R 1 is defined as above; R 2 is selected from the group consisting of CHF 2 , CH 2 CF 3 , and CF 3 CHOH; and R 3 and R 4 are each selected from the group consisting of methyl and hydrogen; and (c) when the compound of formula (I) is a compound of formula (IIIC), then; Y is NR 1 and R 1 is defined as above; R 2 is selected from the group consisting of hydrogen and C 1 -C 6 alkyl, with the proviso that when R 4 is hydrogen, R 2 is not hydrogen; R 3 is CF 3 CHOH; and R 4 is selected from the group consisting of hydrogen and methyl; and (d) when the compound of formula (I) is a compound of formula (IV) then: Y is O; R 2 is CF 3 CHOH; R 3 is selected from the group consisting of methyl and hydrogen; and R 4 is selected from the group consisting of hydrogen and C 1 -C 6 alkyl; or Y is O; R 2 is hydrogen; R 3 is hydrogen; and R 4 is difluoromethyl; or; Y is NR 1 , wherein R is defined as above; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, and R 5 CHOH, wherein R 5 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl and trifluoromethyl; R 3 is hydrogen, methyl, C 1 -C 6 alkyl; and R 4 is CH 2 CF 3 , and CF 3 CHOH; or Y is NR 1 , wherein R 1 is defined as above; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, and R 5 CHOH, wherein R 5 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl and trifluoromethyl; R 3 is CH 2 CF 3 , CH(OCH 3 )CF 3 ; and R 4 is hydrogen, methyl, C 1 -C 6 alkyl.