Patent ID: 8609860

Claim:
A compound of the following general formula (I): wherein Ar is a phenyl group having one or more hydrogens substituted with a substituent independently selected from the group consisting of an C 1-6 alkyl group, a C 1-6 thioalkyl group, a C 3-7 cycloalkyl group which may contain one or more heteroatoms, an C 1-6 alkoxy group, a C 1-6 dialkylamine group, an C 1-6 alkoxycarbonyl group, a C 1-6 trialkylammonium group, a nitro group, a hydroxy group, a C 1-6 perfluoroalkyl group, fluorine, chlorine and bromine, n is 0 or 1, R 1 , R 2 , R 5 and R 6 are independently selected from hydrogen, a linear or branched C 1-8 alkyl group, a phenyl group, a naphthyl group, a biphenyl group or a vinyl benzene group, or a group C, R 3 , R 4 , R 7 and R 8 are independently selected from hydrogen or a group C, with the proviso that not more than one of R 1 to R 8 is a group C, E is a moiety comprising at least one cytostatic agent as an effector unit which is selected from the group consisting of N-nitrosoureas, the anthracyclines doxorubicin, daunorubicin, epirubicin, idarubicin, 2-(4-diacetoxybutyl)doxorubicin; the anthraquinones mitoxantrone and ametantrone; the alkylating agents chlorambucil, bendamustine, melphalan, and oxazaphosphorines; the antimetabolites 5-fluorouracil, 2′-deoxy-5-fluorouridine, cytarabine, cladhbine, fludarabine, pentostatine, gemcitabine, 6-thioguanine and 6-mercaptopurine; the folic acid antagonists methotrexate, raltitrexed, pemetrexed and plevitrexed, the taxanes paclitaxel and docetaxel; the camptothecins topotecan, irinotecan (CPT-11), SN-38, 10-hydroxycamptothecin, GG211, lurtotecan, 9-aminocamptothecin and camptothecin; the lignans etoposide and podophyllotoxin; the Vinca alkaloids vinblastine, vincristine, vindesine and vinorelbine; calicheamicins; maytansinoids; auristatins; epothilones; tubulysins, rapamycin, salinosporamide, combretastatin, bleomycin; dactinomycin; plicamycin; mitomycin C and cis-configured platinum(II) complexes, and C is a carrier group selected from the group consisting of serum proteins, antibodies or antibody fragments, synthetic polymers, dendrimers, peptides, growth factors, receptor-binding ligands, polysaccharids, microparticles, nanoparticles and protein-binding moieties capable of binding to a carrier molecule, wherein the carrier group may be bound to the phenyl ring or to the benzylic carbon atom directly or via a linker.