Patent ID: 7074923

Claim:
A method for producing a compound having the following formula: wherein, R 1 , R 2 and R 3 are each independently selected from the group consisting of: H, C 1-15 alkyl, C 2-15 alkenyl, C 2-15 alkynyl, C 3-15 cycloalkyl, aryl, heteroaryl, â€”OR 5 , â€”C(O)OR 5 , â€”C(O)R 5 , â€”C(O)N(R 5 ) 2 , â€”NHC(O)R 5 and â€”NHC(O)OR 5 , wherein R 5 is H or C 1-15 alkyl; provided that R 2 and R 3 are not both â€”H; R 4 is C 1-12 alkyl, C 3-15 cycloalkyl, C 3-15 cycloalkenyl, heterocycloalkyl, aryl or heteroaryl; wherein R 1 , R 2 , R 3 and R 4 are optionally substituted with one or more moieties independently selected from the group consisting of: C 1-15 alkyl, C 3-15 cycloalkyl, C 2-15 alkenyl, C 3-15 cycloalkenyl, C 2-15 alkynyl, aryl, heteroaryl, heterocycloalkyl, halo, nitro, oximino, acetate, propionate, pivaloyl, â€”OC(O)R 5 , â€”NC(O)R 5 or â€”SC(O)R 5 , â€”OR 50 , â€”NR 50 R 51 , â€”C(O)OR 50 , â€”C(O)R 50 , â€”SO 0-2 R 50 , â€”SO 2 NR 50 R 51 , NR 52 SO 2 R 50 , â•C(R 50 R 51 ), â•NOR 50 , â•NCN, â•C(halo) 2 â€”C(O)N(R 50 R 51 ), â€”OC(O)R 50 , â€”OC(O)N(R 50 R 51 ), â€”N(R 52 )C(O)(R 50 ), â€”(R 52 )C(O)OR 50 and â€”(R 52 )C(O)N(R 50 R 51 ), wherein R 5 is H or C 1-12 alkyl and wherein R 50 , R 51 and R 52 are each independently selected from the group consisting of: H, Cf 1-6 alkyl, C 3-6 cycloalkyl, C 4-6 heterocycloalkyl, heteroaryl, and aryl; Hal is a halogen atom; the method comprising: a) forming a dihalogenated Compound 7 from compound 6: wherein Hal is selected to be the same halogen moiety for each occurrence; and b) reacting a Compound 7 with Compound 8, R 4 NH 2 , and a base, to form a compound of structure 9: wherein, L is selected to be R 3 .