Patent ID: 7560110

Claim:
A method of treating or diagnosing a disease or a condition that may lead to a disease comprising: (A) administering to a subject a bi-specific antibody or fragment thereof having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct; (B) optionally, administering to said subject a clearing composition to clear unbound bi-specific antibodies or fragments thereof from circulation; and (C) administering to said subject a targetable construct comprising a compound of the formula X-Phe-Lys(HSG)-D-Tyr-Lys(HSG)-Lys(Y)—NH 2 (SEQ ID NO: 1), wherein the compound includes a hard acid cation chelator at X or Y, and a soft acid cation chelator at the remaining X or Y, further comprising at least one therapeutic agent, diagnostic agent, or enzyme attached to the targetable construct.