Patent ID: 8236844

Claim:
A histidine derivative represented by the following formula (I) or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 1 is alkyl having 1 to 6 carbon(s) or benzyl which may be substituted with alkyl having 1 to 4 carbon(s) or halogen; R 2 is hydrogen or alkyl having 1 to 4 carbon(s); R 3 and R 4 are same or different and each is hydrogen, alkyl having 1 to 4 carbon(s) or phenyl which may be substituted with any one or two of alkyl having 1 to 6 carbon(s), alkoxy having 1 to 6 carbon(s), halogen, trifluoromethyl, nitro and cyano; and R 5 is hydrogen or an alkyl group having 1 to 4 carbon(s).