Patent ID: 7081458

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: V is —(C═O)—; X is selected from halogen, hydroxy, nitro, cyano, and groups of the formula L–M; Y and Z are each independently: (i) CH; or (ii) nitrogen; with the proviso that Y and Z are not both nitrogen; R 1 and R 2 are each independently selected from hydrogen, halogen, hydroxy, nitro, cyano, and groups of the formula L–M; R 3 is: (i) selected from hydrogen, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl and halo(C 1 –C 6 )alkyl; or (ii) joined with R 10 to form a carbocyclic ring having from 5 to 8 ring members; R 4 is hydrogen, (C 1 –C 6 )alkyl or halo(C 1 –C 6 )alkyl; R 5 is selected from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 1 –C 6 )alkoxy, halo(C 1 –C 6 )alkyl, halo(C 1 –C 6 )alkoxy, mono- and di(C 1 –C 6 )alkylamino, and amino(C 1 –C 6 )alkyl; R 7 is selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L–M; R 8 is selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L–M; U is N CR 9 ; T is N or CR 10 ; R 9 is selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L–M; R 10 is: (i) selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L–M; or (ii) joined with R 3 to form a carbocyclic ring having from 5 to 8 ring members; R 11 is selected from halogen, hydroxy, nitro, —COOH, and groups of the formula L–M; R 12 is independently selected at each occurrence from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 1 –C 6 )alkoxy, halo(C 1 –C 6 )alkyl, halo(C 1 –C 6 )alkoxy, mono- and di(C 1 –C 6 )alkylamino, and amino(C 1 –C 6 )alkyl; L is a bond, —NR 14 —, —O—, —SO 2 —, —SO 2 NH—, —C(═O)NR 14 —, or —NR 14 C(═O)—, wherein R 14 is independently selected at each occurrence from hydrogen, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, and halo(C 1 –C 6 )alkyl; and M is (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, halo(C 1 –C 6 )alkyl, or amino(C 1 –C 6 alkyl).