Patent ID: 7989641

Claim:
A method of synthesizing a 1-(acyloxy)alkyl N-hydroxysuccinimidyl carbonate compound of Formula (I) or a salt thereof comprising: reacting a compound of Formula (V) or a salt thereof with an N-hydroxysuccinimidyl compound of Formula (VII) or a salt thereof to provide the corresponding compound of Formula (I) or a salt thereof: wherein: R 1 is chosen from C 1-6 alkyl, substituted C 1-6 alkyl, C 3-6 cycloalkyl, substituted C 3-6 cycloalkyl, phenyl, substituted phenyl, and C 7-9 phenylalkyl; R 2 and R 3 are independently chosen from hydrogen, C 1-4 alkyl, substituted C 1-4 alkyl, C 1-4 alkoxycarbonyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxycarbonyl, phenyl, substituted phenyl, and C 7-9 phenylalkyl; or R 2 and R 3 together with the carbon atom to which they are bonded form a ring chosen from a cyclobutyl, cyclopentyl, and cyclohexyl ring; R 4 is chosen from C 1-4 alkyl and substituted C 1-4 alkyl wherein each of the one or more substituent groups is independently chosen from halogen, halo-C 1-3 alkyl, hydroxyl, and cyano; each of R 5 , R 6 , R 7 , and R 8 is independently chosen from hydrogen, halogen, C 1-3 alkyl, and halo-C 1-3 alkyl; and R 11 and R 12 are independently chosen from hydrogen, C 1-16 acylamino, C 1-16 acyloxy, C 1-6 alkoxycarbonylamino, C 1-6 alkoxycarbonyloxy, C 1-4 alkyl, substituted C 1-4 alkyl, C 1-6 alkoxy, substituted C 1-6 alkoxy, C 6-12 aryl, substituted C 6-12 aryl, C 7-16 arylalkyl, C 1-6 carbamoyl, C 1-6 dialkylamino, C 5-12 heteroaryl, hydroxyl, and sulfonamide; or R 11 and R 12 together with the atoms to which they are bonded form a ring chosen from a substituted C 3-12 cycloalkyl, substituted C 3-12 heterocycloalkyl, and substituted C 6-12 aryl ring.