Patent ID: 7608632

Claim:
A compound of formula I: wherein: A is selected from the group consisting of —R 1 —C 1 -C 6 alkyl substituted with one or more groups selected from the group consisting of —O-Het A ; each R 1 is independently selected from the group consisting of —C(O); each Het A is independently selected from the group consisting of C 3 -C 7 cycloalkyl; C 5 -C 7 cycloalkenyl; and C 6 -C 10 aryl; and wherein any member of said Het A may be optionally substituted with one or more substituents selected from the group consisting of oxo, —OR 2 , —R 2 , —N(R 2 )(R 2 ), —R 2 —OH, —CN, —CO 2 R 2 , —C(O)—N(R 2 )(R 2 ), —S(O) 2 —N(R 2 )(R 2 ), —N(R 2 )—C(O)—R 2 , —C(O)—R 2 , —S(O) n —R 2 , —OCF 3 , —S(O) n —Ar, methylenedioxy, —N(R 2 )—S(O) 2 (R 2 ), halo, —CF 3 , —NO 2 , Ar and —O—Ar; each R 2 is independently selected from the group consisting of H and C 1 -C 3 alkyl; B, when present, is —N(R 2 )—C(R 3 )(R 3 )—C(O)—; x is 0; each R 3 is independently selected from the group consisting of H, Het, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl and C 5 -C 6 cycloalkenyl, wherein any member of said R 3 , except H, may be optionally substituted with one or more substituents selected from the group consisting of —OR 2 , —C(O)—NH—R 2 , —S(O) n —N(R 2 )(R 2 ), Het, —CN, —SR 2 , —CO 2 R 2 , NR 2 —C(O)—R 2 ; each n is independently 1 or 2; D is C 1 -C 4 alkyl substituted with Ar; D′ is C 1 -C 4 alkyl, which may be optionally substituted with one or more groups selected from C 3 -C 6 cycloalkyl, —OR 2 , —R 3 , —O—Ar and Ar; C 2 -C 4 alkenyl, which may be optionally substituted with one or more groups selected from the group consisting of C 3 -C 6 cycloalkyl, —OR 2 , —R 3 , —O—Ar and Ar; C 3 -C 6 cycloalkyl, which may be optionally substituted with or fused with Ar; and C 5 -C 6 cycloalkenyl, which may be optionally substituted with or fused with Ar; each Ar is independently selected from the group consisting of phenyl; and 3-6 membered carbocyclic ring, wherein said carbocyclic ring may be saturated or unsaturated and optionally substituted with one or more groups selected from the group consisting of oxo, —OR 2 , —R 2 , —N(R 2 )(R 2 ), —N(R 2 )—C(O)—R 2 , C 1 -C 3 alkyl substituted with —OH and optionally substituted with Ar, —CN, —CO 2 R 2 , —C(O)—N(R 2 )(R 2 ), halo and —CF 3 ; E is Het; and each Het is independently selected from the group consisting of 5-7 membered saturated or unsaturated heterocycle, containing one or more heteroatoms selected from N, N(R 2 ), and O wherein said heterocycle may optionally be benzofused; and wherein any member of said Het may be optionally substituted with one or more substituents selected from the group consisting of oxo, —OR 2 , —R 2 , —N(R 2 )(R 2 ), —R 2 —OH, —CN, —CO 2 R 2 , —C(O)—N(R 2 )(R 2 ), —S(O) 2 —N(R 2 )(R 2 ), —N(R 2 )—C(O)—R 2 , —C(O)—R 2 , —S(O) n —R 2 , —OCF 3 , —S(O) n —Ar, methylenedioxy, —N(R 2 )—S(O) 2 (R 2 ), halo, —CF 3 , —NO 2 , Ar and —O—Ar.