Patent ID: 7534419

Claim:
A method of detecting osteoporosis in an individual to be tested comprising: a) obtaining a sample of a bone related tissue or cells; b) assaying a concentration of at least one marker selected from the group consisting of (i) a bacteria is selected from the group consisting of Staphylococcus aureus, Porphyromonas gingivallis, Eikenella corrodens, Acrinobacilus actinomycetemcomitans, Prevotella intermedia, Campylobacter rectus, Staphylococcus epidermidis, Salmonella spp., Neisseria gonorrhoea, NeisseHa meningitis, Myeobacterial tuberculosis, Haemophius influenzae, Pasteurella multocida, B. bronchiseptica , and Fusobacterium nucleatum, (ii) a bacterially produced factor selected from the group consisting of endotoxin-LPS, gapstatin, and dermonecrotic toxin (DNT), and (iii) a heat shock protein (HSP) produced in response to an infectious agent, the HSP selected from the group consisting of HSP 60, gp 96, cpn20, ubiquitin, and cpn 30; and c) comparing the concentration of the at least one marker with the concentration of the marker in a sample of the same bone related tissue or cells from a control individual who does not have osteoporosis.