Patent ID: 6974808

Claim:
A compound having the following structure: or a stereoisomers or pharmaceutically acceptable salts thereof, wherein: A, B and C are selected from CR and N, with the proviso that when one of A, B, and C, is N, the other two of A, B, and C are CR; R is selected from hydrogen and C 1-6 alkyl; R 1 is selected from NR 3 R 4 and R 5 ; R 2 is C 1-6 alkyl; R 3 is selected from hydrogen, C 1-6 alkyl, mono- or di(C 3-6 cycloalkyl)methyl, C 3-6 cycloalkyl; C 3-6 alkenyl; hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyloxyC 1-6 alkyl and C 1-6 alkyloxyC 1-6 alkyl; R 4 and R 5 are independently selected from C 1-8 alkyl, mono- or di(C 3-6 cycloalkyl)methyl, Ar 1 CH 2 , C 3-6 alkenyl, C 1-6 alkyloxyC 1-6 alkyl, hydroxyC 1-6 alkyl, thienylmethyl, furanylmethyl, C 1-6 alkylthioC 1-6 alkyl, morpholinyl, mono- or di(C 1-6 alkyl)aminoC 1-6 alkyl, di(C 1-6 alkyl)amino, C 1-6 alkylcarbonylC 1-6 alkyl, C 1-6 alkyl substituted with imidazolyl; or a radical of the formula —(C 1-6 alkanediyl)-O—CO—Ar 1 ; or R 3 and R 4 taken together with the nitrogen atom to which they are attached form a pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group, optionally substituted with C 1-6 alkyl or C 1-6 alkyloxy; Ar is selected from phenyl substituted with 1, 2 or 3 substituents independently selected from halo, C 1-6 alkyl, triflouromethyl, cyano, C 1-6 alkyloxy, benzyloxy, C 1-6 alkylthio, nitro, amino and mono- and di(C 1-6 alkyl)amino; and pyridinyl substituted with 1, 2 or 3 substituents independently selected from halo, C 1-6 alkyl, triflouromethyl, hydroxy, cyano, C 1-6 alkyloxy, benzyloxy, C 1-6 alkylthio, nitro, amino, mono- and di(C 1-6 alkyl)amino and piperidinyl; and Ar 1 is selected from phenyl, pyridinyl, and phenyl substituted with 1, 2 or 3 substituents independently selected from halo, C 1-6 alkyl, C 1-6 alkyloxy, di(C 1-6 alkyl)aminoC 1-6 alkyl, triflouromethyl and C 1-6 alkyl substituted with morpholinyl.