Patent ID: 8008335

Claim:
A compound of formula I: wherein: W is ═CH— or ═N—; R 1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; R 2 is selected from the group consisting of hydrogen, optionally substituted alkyl, and aryl; R 3 and R 4 , together with the nitrogen atom bound thereto, form a group selected from the group consisting of heterocyclic, substituted heterocyclic, heteroaryl, and substituted heteroaryl; R 5 is -L-A 1 where L is selected from the group consisting of —S(O) r — where r is one or two and C 1 to C 2 straight chain alkylene, optionally substituted with hydroxy, halo and acylamino; A 1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl and substituted cycloalkyl; each R 6 is independently selected from the group consisting of acyl, acylamino, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, amino, substituted amino, aminoacyl, aryl, substituted aryl, aryloxy, substituted aryloxy, carboxyl, carboxyl ester, cyano, cycloalkyl, substituted cycloalkyl, halo, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, hydroxy, nitro, thiol, alkylthio, substituted alkylthio, arylthio, substituted arylthio, heteroarylthio, and substituted heteroarylthio; p is equal to 1, 2 or 3; or pharmaceutically acceptable salts, esters and prodrugs thereof; with the proviso that when W is ═N—, and A 1 is substituted phenyl, said substituted phenyl does not include an ortho substituent of the formula -Q-NR 7 R 8 where Q is a bond, C 1 to C 3 alkyl, C 2 to C 3 alkenyl, C 2 to C 3 alkynyl and R 7 and R 8 are independently C 1 to C 8 alkyl or C 1 to C 8 cycloalkyl optionally substituted with 1 to 3 substituents selected from the group consisting of hydroxy, halo, amino, cyano, nitro, C 1 to C 8 alkyl, C 1 to C 8 cycloalkyl, halo C 1 to C 8 alkyl, C 1 to C 8 alkoxy, halo C 1 to C 8 alkoxy, or R 7 and R 8 jointly with the nitrogen atom to which they are bound form an optionally substituted 3- to 7-membered heterocyclic or an optionally substituted 3- to 7-membered heteroaryl.