Patent ID: 7662977

Claim:
A compound produced by a process comprising reacting Compound 2 of the formula: with a halomethyl ester of the formula: wherein, hal is a halogen atom; Z 1 and Z 2 represent O; Z 3 and Z 4 represent O; R 1 and R 2 independently represent H, optionally substituted aliphatic, optionally substituted aryl, hydroxyl, halogen, alkoxy, heterocycle, cyano, amino, or, are taken together to form an optionally substituted cycloaliphatic or optionally substituted aryl; R 3 represents H, optionally substituted aliphatic, and optionally substituted aryl; R 4 and R 5 independently represent H, optionally substituted aliphatic, optionally substituted aryl, heterocycle, aryloxy, alkoxy, carboxy, or, are taken together to form an optionally substituted heterocycle or optionally substituted heteroaryl; R 6 independently represent H, optionally substituted aliphatic, optionally substituted aryl, heterocycle, aryloxy, alkoxy, amino, or carboxy, and any of which are optionally substituted with a targeting agent (T); and R 7 represents —CH 2 —, —CH(CH 3 ), —CH(Ph), —C(CH 3 )(COOH) or CH(CH(CH 3 ) 2 .