Patent ID: 8212047

Claim:
A method for synthesizing a functionalized pyridyl-amine product comprising the following steps: (a) providing a di-substituted pyridine reactant having the following formula: where X b , X c , and X d are each independently selected from hydrogen and optionally substituted linear, branched, cyclic, heterocyclic, and/or aromatic hydrocarbyl, and where both of X a and X e are halides; (b) selectively activating one of the X a and X e halide moieties on the di-substituted pyridine by contacting the di-substituted pyridine with a hydrocarbyl-mixed metal organometallic compound having a hydrocarbyl portion and a mixed metal portion under conditions sufficient to form a mono-metallated, halo-substituted pyridine intermediate; (c) reacting the mono-metallated, halo-substituted pyridine intermediate with one or more other reactants under conditions sufficient to form a halo-substituted pyridinyl aldehyde intermediate; (d) arylating the halo-substituted pyridinyl aldehyde intermediate by contacting it with an optionally substituted aryl-dihydroxyborane under conditions sufficient to form an (optionally substituted aryl)-substituted pyridinyl aldehyde intermediate; and (e) aminating the (optionally substituted aryl)-substituted pyridinyl aldehyde intermediate by contacting it with one or more other reactants under conditions sufficient to form the functionalized pyridyl-amine product.