Patent ID: 8338459

Claim:
A compound of formula I: or a pharmaceutically acceptable salt, ester, enol ether, enol ester, acetal, ketal, orthoester, hemiacetal, hemiketal, hydrate, or prodrug thereof, wherein: Y is COOH, COOR 5 , CONR 7 R 8 , tetrazolyl, CONHOH, B(OH) 2 , or CONHSO 2 Ar, CONHCH(R 6 )COOH,; X is O; Het is pyridyl, optionally substituted with halo, OR, alkyl or haloalkyl; Ar is aryl, optionally substituted with halo, OR, alkyl or haloalkyl; R is hydrogen, methyl, ethyl, propyl, isopropyl, isobutyl, n-butyl, sec-butyl, tert-butyl, isopentyl, neopentyl, tert-pentyl, isohexyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 5 is haloalkyl, cycloalkyl or heterocyclyl; R 6 is the side chain of a naturally occurring α-amino carboxylic acid; R 7 and R 8 are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl or heteroaryl; and n is an integer from 0-3.