Patent ID: 8614209

Claim:
A compound selected from compounds of the following formula, and pharmaceutically acceptable salts thereof: wherein: —R 2 is —R 2B ; —R 3 is —H; —R 5 is —H; and —Z is -J 3 ; wherein: —R 2B is independently pyrazolyl, isoxazolyl, or pyridyl, and is optionally substituted with one or more substituents independently selected from: —R X1 , —F, —Cl, —Br, —OH, —OR X1 , —CN, —NH 2 , —NHR X1 , and —NR X1 2 , wherein each —R X1 is independently saturated aliphatic C 1-4 alkyl or phenyl; -J 3 is a bridged non-aromatic heterocyclyl group having from 7 to 11 ring atoms, wherein exactly 1 of said ring atoms is a ring heteroatom, and is N, or exactly 2 of said ring atoms are ring heteroatoms, and are both N, or exactly 2 of said ring atoms are ring heteroatoms, and are N and O, or exactly 2 of said ring atoms are ring heteroatoms, and are N and S; with the proviso that -J 3 is not: wherein: -J 3 is optionally substituted with one or more substituents independently selected from: substituents on carbon, independently selected from: —R Q , —R R , —R L —R R , —F, —Cl, —Br, —OH, —OR P , —R L —OH, —R L —OR P , —NH 2 , —NHR P , —NR P 2 , and —CN; substituents on nitrogen, if present, independently selected from: —R Q , —R R , —R L —R R , and —S(═O) 2 R P ; wherein: each —R P is independently —R Q , —R R , or R L —R R ; each —R Q is saturated aliphatic C 1-4 alkyl, and is optionally substituted with one or more fluorine atoms; each —R R is independently phenyl, furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, or pyridazinyl, and is optionally substituted with one or more substitutents independently selected from: —F, —Cl, —Br, —R K1 , —CF 3 , —OH, —OR K1 , —OCF 3 , —NH 2 , —NHR K1 , —NR K1 2 , and —CN, wherein each —R K1 is saturated aliphatic C 1-4 alkyl; and each —R L — is saturated aliphatic C 1-4 alkylene.