Patent ID: 6900214

Claim:
A compound of formula IA its enantiomers, diastereomers, pharmaceutically acceptable salts, and solvates thereof, wherein R 1 is selected from the group consisting of hydrogen, alkyl and cycloalkyl; (Y 1 , Y 2 , Y 3 Y 4 and Y 5 are independently selected from the group consisting of H, halogen, lower alkyl, aryl, heteroaryl, O alkyl, O aryl, NH alkyl, NH aryl, N alkyl alkyl, N alkyl aryl, N aryl aryl with the proviso that at least one of Y 1 , Y 2 , Y 3 Y 4 and Y 5 is aryl or heteroaryl; R 4 is selected from the group consisting of alkyl, arylalkyl, cycloalkylalkyl, aminoalkyl, heteroarylalkyl, heterocycloalkylalkyl, CN, COR 5 , CO 2 R 5 CONR 5 R 6 and COSR 5 ; R 5 and R 6 are independently selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, aminoalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, and heterocycloalkylalkyl; Z is selected from the group consisting of O, S and NR 8 ; R 8 is selected from the group consisting of H, CN, sulfonamido, OR 7 , alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl and heteroarylalkyl; and R 7 is selected from the group consisting of H, alkyl, arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, and heteroarylalkyl.