Patent ID: 7045133

Claim:
A monomeric monocyclic peptide which interferes with a biological activity of at least one factor selected from the group consisting of VEGF, VEGF-C, and VEGF-D mediated by at least one receptor selected from the group consisting of VEGF receptor-2 and VEGF receptor 3, wherein the monomeric monocyclic peptide comprises a cyclic core consisting of a core sequence and a first linking group at one end of the core sequence, and a second linking group at the other end of the core sequence, wherein the core sequence consists of (a) a receptor-binding loop 1, 2 or 3 of VEGF-D, selected from the group consisting of SEQ ID NO:7; SEQ ID NO :10; SEQ ID NO:11; SEQ ID NO:12; SEQ ID NO:13 and SEQ ID NO:14, (b) a loop fragment consisting of a sequence selected from the group consisting of SEQ ID NO:5; SEQ ID NO:6; SEQ ID NO:7; SEQ ID NO:10; SEQ ID NO:11; SEQ ID NO:12; SEQ ID NO:13 and SEQ ID NO:14 with one or more conservative amino acid substitutions, or (c) a loop fragment consisting of a sequence selected from the group consisting of SEQ ID NO:5; SEQ ID NO:6;SEQ ID NO:7; SEQ ID NO:10; SEQ ID NO:11; SEQ ID NO:12; SEQ ID NO:13 and SEQ ID NO:14 with one or two amino acid residues deleted or inserted, wherein the first and second linking groups are connected to form a constraint that cyclize the peptide such that receptor-binding loops 1, 2 or 3 or the corresponding loop fragment mimics a native conformation in the corresponding region of VEGF-D.