Patent ID: 7399862

Claim:
A compound of formula (I): or a pharmaceutically-acceptable salt or stereoisomer thereof, wherein: R 1 is hydrogen, halo, hydroxy, C 1-4 alkyl, or C 1-4 alkoxy; R 2 is C 3-4 alkyl or C 3-6 cycloalkyl; R 3 is hydrogen or C 1-3 alkyl; R 4 is —S(O) 2 —C 1-3 alkyl, —C(O)O—C 1-3 alkyl or —C(O)—C 1-3 alkyl; n is an integer of 1, 2, or 3; Y is selected from: (a) a moiety of formula (a) wherein: Z is selected from —N(R 8 )SO 2 R a , —N(R 8 )C(O)R c , —S(O 2 )R 8 , —N(R 8 )C(O)OR d , —N(R 8 )C(O)NR e R f , —N(R 8 )SO 2 NR g R h , —C(O)NR i R j , —OC(O)NR k R l , —C(O)OR m , —OR 8 , —SR n , cyano, hydroxy-substituted C 1-4 alkyl, hydroxy-substituted C 1-3 alkoxy, —CF 3 , pyridinyl, thiomorpholinyl, thiazolidinyl, imidazolyl, indolyl, tetrahydrofuranyl, pyrrolidinyl and piperidinyl, wherein pyrrolidinyl is optionally substituted with oxo and piperidinyl is optionally substituted with 1 to 3 halo; R 5 is selected from hydrogen and C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with 1 to 2 substituents selected from hydroxy, halo, and C 1-3 alkoxy; m is an integer of 0, 1, 2, 3, 4, or 5; R 6 and R 7 are independently selected from hydrogen, hydroxy, halo and C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with 1 to 2 substituents selected from hydroxy, C 1-3 alkoxy, and cyano; R 8 is independently hydrogen or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with 1 to 2 substituents selected from hydroxy, C 1-3 alkoxy, and cyano; R a is hydrogen or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with —SO 2 R b , C 3-6 cycloalkyl or with from 1 to 3 halo; R c is hydrogen or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with 1 to 2 substituents selected from hydroxy and C 3-6 cycloalkyl, or with from 1 to 3 halo; and R b , R d , R e , R f , R g , R h , R i , R j , R k , R l , R m , and R n , are independently hydrogen or C 1-4 alkyl; or R 5 and R 6 , R 5 and R 8 , or R 6 and R 8 , taken together form a C 2-5 alkylene, wherein the C 2-5 alkylene is optionally substituted with 1 to 2 substituents selected from hydroxy, halo and C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with 1 to 2 substituents selected from hydroxy, C 1-3 alkoxy, and cyano; or R 8 and R a taken together form a C 2-5 alkylene; provided that when m is 1, Z forms a carbon-carbon bond with the carbon atom bearing the substituents R 6 and R 7 ; and when m is 0, Z is selected from —S(O 2 )R 8 , —C(O)NR i R j , —C(O)OR m , and —CF 3 ; and (c) —SR 10 , wherein R 10 is hydrogen or C 1-4 alkyl.