Patent ID: 7879815

Claim:
A compound of the structural formula I: or a pharmaceutically acceptable salts thereof; wherein n is 0, 1, or 2; Ar is phenyl, naphthyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, quinolinyl, or isoquinolinyl, wherein Ar is optionally substituted with one to five substituents independently selected from the group consisting of halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, cyano, nitro, amino, carboxy, trifluoromethyl, trifluoromethoxy, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 alkylcarbonyl, C 1-4 alkylcarbonyloxy, and C 1-4 alkyloxycarbonyl; R 1 is hydrogen or fluoro; R 2 is fluoro, methoxy, or OR 10 ; R 3 is selected from the group consisting of hydrogen, C 1-16 alkylcarbonyl, C 2-18 alkenylcarbonyl, C 1-10 alkyloxycarbonyl, C 3-6 cycloalkylcarbonyl, C 3-6 cycloalkyloxycarbonyl, and an amino acyl residue of structural formula: R 10 is selected from the group consisting of hydrogen, C 1-16 alkylcarbonyl, C 2-18 alkenylcarbonyl, C 1-10 alkyloxycarbonyl, C 3-6 cycloalkylcarbonyl, C 3-6 cycloalkyloxycarbonyl, and an amino acyl residue of structural formula: or R 3 and R 10 together with the oxygen atoms to which they are attached form a five-membered cyclic carbonate; R 4 is hydrogen, C 1-5 alkyl, phenyl, or benzyl; wherein alkyl is optionally substituted with one substituent selected from the group consisting of fluorine, hydroxy, methoxy, amino, carboxy, carbamoyl, guanidino, mercapto, methylthio, 1H-imidazolyl, and 1H-indol-3-yl; and wherein phenyl and benzyl are optionally substituted with one to two substituents independently selected from the group consisting of halogen, hydroxy, and methoxy; R 5 is hydrogen or methyl; or R 4 and R 5 together with the carbon atom to which they attached form a 3- to 6-membered aliphatic spirocyclic ring system; R 6 is hydrogen, C 1-16 alkyl, C 2-20 alkenyl, (CH 2 ) n C 3-6 cycloalkyl, phenyl, benzyl, or adamantyl; wherein alkyl, alkenyl, cycloalkyl, and adamantyl are optionally substituted with one to three substituents independently selected from halogen, hydroxy, carboxy, C 1-4 alkoxy; and wherein phenyl and benzyl are optionally substituted with one to three substituents independently selected from halogen, hydroxy, cyano, C 1-4 alkoxy, trifluoromethyl, and trifluoromethoxy; R 7 is hydrogen, C 1-5 alkyl, or phenyl C 0-2 alkyl; R 8 is hydrogen, C 1-4 alkyl, C 1-4 acyl, benzoyl, C 1-4 alkyloxycarbonyl, phenyl C 0-2 alkyloxycarbonyl, C 1-4 alkylaminocarbonyl, phenyl C 0-2 alkylaminocarbonyl, C 1-4 alkylsulfonyl, or phenyl C 0-2 alkylsulfonyl; and R 9 is hydrogen, C 1-8 alkylcarbonyl, or C 1-8 alkyloxycarbonyl.