Patent ID: 7317025

Claim:
A compound of the formula: wherein the fused pyrrolidine ring optionally contains a single carbon-carbon double bond or a single carbon ring member adjacent to the nitrogen is optionally ═O substituted; n is 1 or 2; m is 0, 1, or 2; Y 1 is a C 0-5 alkylene, C 0-5 alkenylene, C 0-5 alkynylene, C 0-5 acylene; —CH(CONR f R g )— (where R f and R g are independently H or C 1-4 alkyl), or —CH(CO 2 C 1-4 alkyl)—; Y 2 is H, phenyl, C 4-8 cycloalkyl or C 4-8 cycloalkenyl, each ring optionally substituted with R q ; Y 3 is —CH 2 —, carbonyl or sulfone; Y 4 is a substituted or unsubstituted C 2-7 alkyl, C 2-7 alkenyl, C 2-7 alkynyl or C 3-7 cycloalkyl; Y 5 is phenyl, furanyl, thiophenyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, dioxolanyl, oxazolyl, thiazolyl, imidazolyl, imidazolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, oxadiazolyl, triazolyl, thiadiazolyl, pyranyl, pyridyl, piperidinyl, dioxanyl, morpholinyl, dithianyl, thiomorpholinyl, pyridazinyl, pyrimidinyl, pyrazinyl, piperazinyl, naphthalenyl, quinolonyl, purinyl, indolyl, benzofuranyl, or benzothiophenyl, each optionally mono-, di- or tri-substituted with R q ; R 1 is H or is where R a is H, a substituted or unsubstituted C 1-5 alkyl, C 1-5 alkenyl, C 1-5 alkynyl or C 1-5 acyl, where the substituent is C 1-4 alkoxy or one or more fluoro; R 2 and R 3 are independently selected from H, a substituted or unsubstituted C 1-5 alkyl, C 1-5 alkenyl, or C 1-5 alkynyl, or R 2 and R 3 may be taken together with the nitrogen of R 3 attachment to form piperidine or pyrrolidine or azepine; and R q is selected from the group consisting of —OH, —C 1-6 alkyl, —OC 1-6 alkyl, Ph—, —OPh, benzyl, —Obenzyl, —C 3-6 cycloalkyl, —OC 3-6 cycloalkyl, —CN, —NO 2 , —N(R y )R z (wherein R y and R z are independently selected from H, C 1-6 alkyl, C 1-6 alkenyl, or R y and R z may be taken together with the nitrogen of attachment to form an otherwise aliphatic hydrocarbon ring, said ring having 4 to 7 members, optionally having one carbon replaced with O, ═N—, NH or N(C 1-4 alkyl), optionally having one carbon substituted with —OH, and optionally having one or two unsaturated bonds in the ring), —(C═O)N(R y )R z , —(N—R t )COR t , —(N—R t )SO 2 C 1-6 alkyl (wherein R t is H or C 1-6 alkyl or two R 1 in the same substituent may be taken together with the amide of attachment to form an otherwise aliphatic hydrocarbon ring, said ring having 4 to 6 members), —(C═O)C 1-6 alkyl, —(S═(O) n )—C 1-6 alkyl (wherein n is selected from 0, 1 or 2), —SO 2 N(R y )R z , —SCF 3 , halo, —CF 3 , —OCF 3 , —COOH and —COOC 1-6 alkyl; and enantiomers, diastereomers, hydrates, solvates and pharmaceutically acceptable salts, esters and amides thereof, with the proviso that the compound of formula (I) cannot include a compound of the formula: