Patent ID: 7365065

Claim:
A compound of formula 1, or a pharmaceutically acceptable salt thereof, wherein: A 1 , A 2 and A 3 are each independently selected from A 5 and A 6 ; and A 4 is either a covalent bond or A 5 ; provided that when A 4 is a covalent bond then one of A 1 -A 3 is A 6 and the other two are A 5 and that when A 4 is A 5 then all of A 1 -A 3 are A 5 ; A 5 is selected from C—R 13 and N; A 6 is selected from N—R 14 , S and O; R 1 is selected from H, NHY 1 and COY 2 and R 2 is H; or R 1 and R 2 are both methyl or together are ═O; R 3 , R 4 and R 5 are each independently H, lower alkyl or lower alkenyl; R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are each independently selected from H, lower alkyl, lower alkenyl, NH 2 , F, Cl, Br, O-alkyl, O-lower alkenyl, CH 2 NMe 2 and CF 3 ; R 13 is selected from H, F, Cl, Br, NO 2 , NH 2 , OH, Me, Et, OMe, NMe 2 and CF 3 ; R 14 is selected from H, methyl and ethyl; W is CH; X is O; Y 1 is selected from CO-lower alkyl, CO-lower alkenyl, CO(CH 2 ) b Y 3 , CO(CH 2 ) b COY 3 and CO(CH 2 ) b NHCOY 3 ; Y 2 is selected from OR 15 , NR 16 R 17 and NH(CH 2 ) c COY 3 ; Y 3 is selected from alkyl, lower alkenyl, OR 15 and NR 16 R 17 ; R 15 is selected from H, lower alkyl, lower alkenyl and (CH 2 ) a R 18 R 16 and R 17 are each independently selected from H, lower alkyl, lower alkenyl and (CH 2 ) a R 18 , or together are —(CH 2 ) 2 -Z-(CH 2 ) 2 —; R 18 is selected from OH and phenyl, pyridyl, pyrimidinyl, pyrazinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, oxadiazolyl and thiadiazolyl, each of which may optionally have a lower alkyl, lower alkenyl group substituent; Z is selected from O, CH 2 , S, SO 2 , NH, N-lower alkyl and N-lower alkenyl; a is 0-4; and b and c are 1-3.