Patent ID: 8206701

Claim:
A method for the generation of HLA-haploidentical antigen-presenting cells for the treatment of tumor diseases in a patient comprising the following steps: providing a patient to be treated; providing antigen-presenting cells from a semi-allogeneic donor which are HLA-haploidentical with respect to those of the patient, wherein HLA-haploidentical antigen-presenting cells have class I and class II molecules in common with the patient; and introducing proteins and/or peptides or RNA or DNA or cDNA encoding said proteins and/or peptides into the HLA-haploidentical antigen-presenting cells, wherein said proteins and/or peptides are tumor-defined antigens or wherein said RNA or DNA or cDNA encodes tumor-defined antigens, wherein the tumor-defined antigens are antigens overexpressed in the tumor cells, wherein the tumor-defined antigens are selected from the group consisting of oncogenes, proteins providing a growth advantage to the tumor and/or ensuring its survival, cell cycle regulatory proteins, transcription factors, mucins, and proteins involved in the regulation of cell division.