Patent ID: 7696309

Claim:
An isolated mutant form of stromal cell derived factor-1 (SDF-1) peptide comprising a mutant SDF-1 (mSDF-1) or X p -mSDF-1, wherein: a) X is proteinogenic amino acid(s) or a protease protective organic group; b) p is any integer from 1 to 4; c) said mSDF-1 comprises the amino acid sequence of SEQ ID NO:53, wherein mSDF-1 maintains chemoattractant activity for T cells and is inactivated by matrix metalloproteinase-2 (MMP-2) at a rate that is less than one-half of the rate of inactivation of native SDF-1; and d) X p -mSDF-1 is a mutant form of said SDF-1 comprising the amino acid sequence of SEQ ID NO: 53, wherein Xe-mSDF-1 maintains chemoattractant activity for T cells, is inactivated by dipeptidyl peptidase IV (DPPIV) at a rate that is less than one-half of the rate at which native SDF-1 is inactivated, and is inactivated by MMP-2 at a rate that is less than one-half of the rate of inactivation of native SDF-1.