Patent ID: 7470680

Claim:
A compound of Formula I where: A is O or NR 1 ; R 1 is alkyl, alkenyl, cycloalkyl, C 5-7 cycloalkenyl, (cycloalkyl)alkyl, haloalkyl, alkoxyalkyl, (Ar 1 )alkyl, (NR 7 R 8 )alkyl, N—(R 9 )-pyrrolidinyl or N—(R 9 )-piperidinyl; R 2 is hydrogen, halo, alkyl, or alkenyl; R 3 is hydrogen, halo, alkyl, or alkenyl; or R 2 and R 3 taken together is N(R 13 )N═C(R 4 ); R 4 is hydrogen, halo, alkyl, or alkenyl; NR 5 R 6 taken together is R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; or NR 7 R 8 taken together is selected from the group consisting of pyrrolidinyl, piperidinyl, N—(R 9 )-piperazinyl, morpholinyl, and thiomorpholinyl; R 9 is hydrogen, alkyl, alkylcarbonyl, or alkoxycarbonyl; R 10 is phenyl, naphthyl, pyridinyl, pyridinyl N-oxide, quinolinyl, quinolinyl N-oxide, isoquinolinyl, or isoquinolinyl N-oxide, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, haloalkyl, alkoxy, hydroxy, and phenyl; or R 10 is selected from the group consisting of R 11 is hydrogen, halo, alkyl, haloalkyl, or alkoxy; R 12 is selected from the group consisting of R 13 is hydrogen, alkyl, alkenyl, alkoxyalkyl, or benzyl; Ar 1 is phenyl, naphthyl, pyridinyl, or imidazolyl, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, and haloalkyl; Ar 2 is phenyl, naphthyl, or pyridinyl, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, and haloalkyl; X—Y is aminocarbonyl, oxycarbonyl, methylenecarbonyl, ethylene, or amino(cyano)iminomethyl; Z is N or CH; and the carbon bearing the asterisk is either the (S) configuration or the (R) configuration; or a pharmaceutically acceptable salt thereof.