Patent ID: 8859599

Claim:
A compound of general formula (I): wherein R is: H, aryl, optionally substituted aryl, heteroaryl, optionally substituted heteroaryl, straight or branched C 1-10 alkyl, wherein the alkyl may be substituted with one or more substituents which may be the same or different, and include halo, cycloalkyl containing three to six carbon atoms, hydroxy, alkoxy, amino, acylamino, aroylamino, carboxy, alkoxycarbonyl, aralkyloxycarbonyl; R is also C 1 -C 4 -arylalkyl, C 1-4 heteroarylalkyl or substituted heterocyclylalkyl; R 9 is H, F, Cl, I or Br; R 7 is H, CN, NO 2 , F, Cl, I, Br, carbamoyl, or alkyl, alkoxy, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, perfluoroalkyl, perfluoroalkylthio, perfluoroalkylsulphinyl or perfluoroalkysulphonyl each being substituted or unsubstituted and having up to 4 carbon atoms, or phenyl, phenylthio, phenylsulphinyl or phenylsulphonyl; each being substituted or unsubstituted; R 8 is cyano, carbamoyl, nitro, fluoro, chloro, bromo, iodo or hydrogen, or alkyl, alkoxy, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, perfluoroalkyl, perfluoroalkylthio, perfluoroalkylsulphinyl or perfluoroalkylsulphonyl each being substituted or unsubstituted and having up to 4 carbon atoms, or phenyl, phenylthio, phenylsulphinyl or phenylsulphonyl, each being substituted or unsubstituted; R 10 is C 1 -C 4 alkyl or a bond; R 16 is H, C 1 -C 4 -alkyl, —CO—, —CS—, —SO—, —SO 2 —, —R p CS—, —R p CO—, —R p SO—, —R p SO 2 — wherein R p is a C 1 -C 4 alkyl and with the condition that when R 16 is —CO— or —CS—, it is connected to NHR 11 to form a cycle; C 1 -C 4 -alkyl, —SO—, —SO 2 —, —R p CS—, —R p CO—, —R p SO—, —R p SO 2 — can also be connected to NHR 11 to form a cycle; R 11 is H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 hetero alkyl, substituted C 1 -C 6 hetero alkyl, aryl, substituted aryl, C 1 -C 4 -alkylaryl, hetero aromatic C 1 -C 4 alkyl, aromatic hetero cycle, substituted aromatic hetero cycle, a protecting group or a chiral auxiliary; wherein the protecting group is selected from the group consisting of —COR r , —COOR r , —OSO 2 R r , —SO 2 R r , and —SR r ; wherein the chiral auxiliar is selected from the group consisting of —OS(O)R r and —OP(O)R s R r where R r and R s can be the same or different; R r and R s are selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 halo-alkyl, aryl, substituted aryl, aromatic hetero cycle, and substituted aromatic hetero cycle; and A has the structure of formula II: wherein R 4 is substituted or unsubstituted alkyl (alkylene) having up to 6 carbon atoms; X 4 is oxygen, sulfur, sulfinyl (—SO—), sulfonyl (—SO 2 —) imino (—NH—) or alkylimino (—NR n —) wherein R n is H, C 1 -C 4 alkyl; R 5 is a direct bond or a substituted or unsubstituted alkylene having up to 6 carbon atoms; R 6 is selected from the group consisting of furyl, thienyl, pyrrolyl, pyridyl, imidazolyl, thiazolyl, pyrimidinyl, thiadiazolyl, triazolyl, benzimidazolyl, benzothiazolyl, indolyl, benzothienyl, quinolyl, isoquinolyl, benzofuryl, and 1,2-dihydro-2-oxoquinolyl.