Patent ID: 7687637

Claim:
A compound of formula I in free or salt form, wherein R 1 is C 1 -C 8 -alkylcarbonyl optionally substituted by the group consisting of, hydroxy, C 1 -C 8 -alkylamino, carboxy, C 1 -C 8 -alkoxycarbonyl, nitrile, phenyl, C 1 -C 8 -haloalkyl, C 1 -C 8 -alkyl optionally substituted by hydroxy, C 3 -C 8 -cycloalkyl optionally substituted by hydroxy, C 1 -C 8 -alkoxy optionally substituted by hydroxy, phenyl substituted by hydroxy or C 1 -C 8 -alkyl and, 5- or 6-membered unsaturated heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that heterocyclic ring being optionally substituted by hydroxy, C 1 -C 8 -alkyl or C 1 -C 8 -alkoxy, R 2 is C 1 -C 3 -alkyl or halogen; R 5 is hydrogen or halogen; R 3 is hydrogen, hydroxy, amino, —SOR 8 , —SO 2 R 8 , —SO 2 NH 2 , —SO 2 NR 9 R 10 , —COR 8 , —CONHR 8 , —NHSO 2 R 8 , nitrile, carboxy, —OR 8 or C 1 -C 8 -haloalkyl; R 4 is —NR 12 R 13 ; R 8 is C 1 -C 8 -alkyl or C 3 -C 8 -cycloalkyl, optionally substituted by halogen, hydroxy, C 1 -C 8 -alkoxy, nitrile, amino, C 1 -C 8 -alkylamino or di(C 1 -C 8 -alkyl)amino; R 9 is C 1 -C 8 -alkyl or C 3 -C 8 -cycloalkyl, optionally substituted by hydroxy, C 1 -C 8 -alkoxy, nitrile, amino, C 1 -C 8 -alkylamino, di(C 1 -C 8 -alkyl)amino or a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by C 1 -C 8 -alkyl; R 10 is hydrogen or C 1 -C 8 -alkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring that contains one or more further hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by C 1 -C 8 -alkyl; and R 12 and R 13 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring that contains one or more further hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by C 1 -C 8 -alkyl.