Patent ID: 8450333

Claim:
A method of inhibiting mitochondrial fission in mammalian cells comprising contacting the cells with a compound of the general formula: wherein R 1 is independently H; a C1-C18 alkyl or C1-C18 heteroalkyl, which may be branched, may be substituted, or combinations thereof; a C1-C18 alkenyl or C1-C18heteroalkenyl, which may be branched, may be substituted, or combinations thereof; a C1-C18alkynyl or C1-C18 heteroalkynyl, which may be branched, may be substituted, or combinations thereof; a C3-C18 aryl or C3-C18 heteroaryl, which may contain a bridge, may be substituted, or combinations thereof; or a C5-C18 cycloalkyl or C5-C18 heterocycle, which may contain a bridge, may be substituted, or combinations thereof; R 2 is H; a C1-C18 alkyl or C1-C18 heteroalkyl, which may be branched, may be substituted, or combinations thereof; or a halogen; R 3 is H; a C1-C18 alkyl or C1-C18 heteroalkyl, which may be branched, or may be substituted, or combinations thereof; R 4 is a halogen; and R 5 is a halogen, thereby inhibiting mitochondrial fission in the mammalian cells.