Patent ID: 8263346

Claim:
A method for screening a suppressor of lymphocyte migration activity, comprising the following steps (a) to (c): (a) activating Rac with DOCK2 by stimulating lymphocytes with one or more chemokines in vitro in the presence or absence of a test substance; (b) performing at least one of the following steps (b1) to (b3): (b1) detecting a GTP-bound activated Rac; (b2) measuring a change in actin polymerization; and (b3) measuring lymphocyte migration; and (c) determining the test substance to be a DOCK2-mediated suppressor of lymphocyte migration activity when at least one of Rac activation, actin polymerization, and lymphocyte migration in the above step (b) is suppressed in the presence of the test substance as compared to a case in the absence of the test substance.