Patent ID: 7485432

Claim:
A method of identifying a compound that selectively modulates at least one TLR7-mediated cellular activity or at least one TLR8-mediated cellular activity, the method comprising: contacting a test compound with human cells that naturally express TLR7 and detecting modulation of a TLR7-mediated cellular activity; contacting the test compound with human cells that naturally express TLR8 and detecting modulation of a TLR8-mediated cellular activity; and identifying the test compound as a compound that selectively modulates at least one TLR7-mediated cellular activity if the test compound modulates the TLR7-mediated cellular activity to a greater extent than it modulates the TLR8-mediated cellular activity and identifying the test compound as a compound that selectively modulates at least one TLR8-mediated cellular activity if the test compound modulates the TLR8-mediated cellular activity to a greater extent than it modulates the TLR7-mediated cellular activity, wherein the TLR7 mediated cellular activity or TLR8 mediated cellular activity comprises inducing production of a cytokine, co-stimulatory marker, intercellular adhesion molecule, proliferation/maturation marker, or a combination thereof.