Patent ID: 7576105

Claim:
A compound of Formula (I): wherein: Ar is aryl; m is an integer from 0 to 2, n is an integer from 0 to 2, with the proviso that m and n are not both simultaneously 0; R 1 is selected from the group consisting of hydrogen, C 1-8 alkyl, C 2-8 alkenyl, aryl, aryl(C 1-8 )alkyl, amino(C 1-8 )alkyl, C 1-8 alkyl-NH—(C 1-8 )alkyl, (C 1-8 alkyl) 2 —N—(C 1-8 )alkyl, hydroxy(C 1-8 )alkyl and C 1-8 alkoxy(C 1-8 )alkyl; R 2 and R 3 are optionally present and independently selected from C 1-8 alkyl; R 4 is one to three substituents independently selected from the group consisting of hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, aryl(C 1-8 )alkyl, C 1-8 alkoxy, aryloxy, aryl(C 1-8 )alkyloxy, C 1-8 alkylthio, trifluoro(C 1-8 )alkyl, trifluoro(C 1-8 )alkoxy, amino, —NH(C 1-8 )alkyl, —N[(C 1-8 )alkyl] 2 , —NH(aryl), —N(aryl) 2 , —NH(C 1-8 )alkylaryl, —N[(C 1-8 )alkylaryl] 2 , —CO 2 H, —CO 2 (C 1-8 )alkyl, —CO 2 (aryl), —C(O)NH 2 , —C(O)NH(C 1-8 )alkyl, —C(O)N[(C 1-8 )alkyl] 2 , —NHC(O)(C 1-8 )alkyl, —SO 2 H, —SO 2 (C 1-8 )alkyl, —S(O 2 )NH 2 , —S(O 2 )NH(C 1-8 )alkyl, —S(O 2 )N[(C 1-8 )alkyl] 2 , —C(O)(C 1-8 )alkyl, —C(O)aryl, —C(O)(C 1-8 )alkylaryl, aryl, halogen, hydroxy, cyano, and nitro; X is selected from the group consisting of O and S; Z is N(R 5 )(R 6 ); R 5 and R 6 are independently selected from the group consisting of hydrogen, C 1-8 alkyl, hydroxy(C 1-8 )alkyl, C 2-8 alkenyl, C 3-8 cycloalkyl, aryl and aryl(C 1-8 )alkyl, wherein said cycloalkyl, aryl and the aryl portion of aryl(C 1-8 )alkyl are optionally substituted with one to three substituents independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 1-8 alkoxy, trifluoro(C 1-8 )alkyl, trifluoro(C 1-8 )alkoxy, C 3-8 cycloalkyl and halogen; and, the moiety —C(X)Z is attached on the phenyl at the 3 or 4 position; and pharmaceutically acceptable enantiomers, diastereomers and salts thereof.