Patent ID: 7091323

Claim:
A purified human antibody, wherein the antibody: binds to a tissue inhibitor of metalloprotease-1 (TIMP-I); neutralizes a matrix metalloprotease (MMP)-inhibiting activity of the TIMP-1; and comprises: a VHCDR1 region comprising an amino acid sequence as set forth in SEQ ID NO:355; a VHCDR2 region comprising an amino acid sequence as set forth in SEQ ID NO:359; a VHCDR3 region comprising an amino acid sequence as set forth in SEQ ID NO:360; a VLCDR1 region comprising an amino acid sequence as set forth in SEQ ID NO:363; a VLCDR2 region comprising an amino acid sequence as set forth in SEQ ID NO:364; and a VLCDR3 region comprising an amino acid sequence as set forth in SEQ ID NO:48.