Patent ID: 8409568

Claim:
An isolated antibody comprising a variant human IgG1 Fc region having a reduced affinity for an effector molecule wherein said human IgG1 Fc region comprises an amino acid substitution, insertion or combination thereof selected from the group consisting of: W277T; K246R/L251E/T260R; InR234/235; InV235/236; InR236/237; InR237/238; InV238/239; InN238/239; InL238/239; InE238/239; InG238/239; InS239/240; InG240/241; InE240/241; InG240/241/1198T; InL238/239/P238Q; InE238/239N348A; InS239/240/V266A; InR237/238/G236A, wherein the numbering is according to EU index as set forth in Kabat.