Patent ID: 7446114

Claim:
A compound of formula (I): wherein R 1 is hydrogen, halo, or C 1-4 alkyl; R 2 is C 3-4 alkyl or C 3-6 cycloalkyl; a is 0 or 1; Z is a moiety of formula (a): wherein: b is 1, 2 or 3; d is 0 or 1; X is carbon and Q is selected from -A-, -A(CH 2 ) 2 N( 4 )—, and —S(O) 2 (CH 2 ) 2 N(R 4 )—; or X is nitrogen and Q is selected from —S(O) 2 CH 2 C(O)—, —SCH 2 C(O)—, —OC(O)—, —S(O) 2 —, —S(O) 2 (CH 2 ) 2 —, -A(CH 2 ) 2 —, G is W and c is 0, wherein W is selected from —N{C(O)R 9 }—, —N{S(O) 2 R 10 }—, —N{C(O)OR 12 }—, —N{C(O)NR 13 R 14 }—, —N{S(O) 2 NR 13 R 14 }—, —N{R 16 }—, —S(O) 2 —, —O—, and —S—; provided that when G is W, c is 0, and b is 1, then X is carbon; or G is carbon, c is 1, and Y is a moiety of formula (b): wherein: e is 0 or 1; W′ is selected from —N(R 8 )C(O)R 9 , —N(R 8 )S(O) 2 R 10 , —S(R 11 )(O) 2 , —N(R 8 )C(O)OR 12 , —N(R 8 )C(O)NR 13 R 14 , —N(R 8 )S(O) 2 NR 13 R 14 , —C(O)NR 13 R 14 , —OC(O)NR 13 R 14 , —C(O)OR 12 , —OR 15 , and —N(R 8 )R 16 ; provided that when X is nitrogen, e is 0, and W′ is attached to a carbon bonded to X, then W′ is —C(O)NR 13 R 14 or —C(O)OR 12 ; A is selected from —S(O) 2 CH 2 C(O)N(R 3 )—, —N{C(O)R 5 }—, —N{C(O)NR 6a R 6b }—, —N{S(O) 2 C 1-3 alkyl}-, —N{S(O) 2 NR 6a R 6b }—, —S(O) 2 N(R 7a )—, and —OC(O)N(R 7b )—; R 3 and R 4 are independently C 1-4 alkyl; R 5 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, C 4-6 cycloalkyl, or pyrimidin-4-yl; R 6a and R 6b are independently hydrogen, C 5-6 cycloalkyl, or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with hydroxy, C 1-3 alkoxy, or cyano; R 7a and R 7b are independently hydrogen or C 1-4 alkyl; R 8 is hydrogen or C 1-4 alkyl; R 9 is hydrogen, furanyl, tetrahydrofuranyl, pyridinyl, or C 1-4 alkyl; R 10 is C 1-4 alkyl, optionally substituted with S(O) 2 C 1-3 alkyl, or with from 1 to 3 halo; R 11 is —NR 13 R 14 , or C 1-4 alkyl; R 12 is C 1-4 alkyl; R 13 , R 14 , and R 15 are independently hydrogen or C 1-4 alkyl; R 16 is —(CH 2 ) r —R 17 , wherein r is 0, 1, 2, or 3; R 17 is hydrogen, hydroxy, cyano, C 1-3 alkyl, C 1-3 alkoxy, —C(O)NR 13 R 14 , —CF 3 , pyrrolyl, pyrrolidinyl, pyridinyl, tetrahydrofuranyl, —N(R 8 )C(O)OR 12 , —OC(O)NR 13 R 14 , —N(R 8 )S(O) 2 CH 3 , —S(O) 2 NR 13 R 14 , or 2-oxoimidazolidin-1-yl, wherein C 1-3 alkoxy is optionally substituted with hydroxy; provided that when r is 0, R 17 is selected from hydrogen, C 1-3 alkyl, and pyridinyl; and when r is 1, R 17 is hydrogen or R 17 forms a carbon-carbon bond with the —(CH 2 ) r — carbon atom; R 18 is C 1-3 alkyl optionally substituted with hydroxy; or a pharmaceutically-acceptable salt or stereoisomer thereof.