Patent ID: 8519164

Claim:
A process for the preparation of a compound of formula (7): wherein: R is a substituted or unsubstituted alkenyl or aryl group or any combination thereof, or a substituted or unsubstituted heterocyclic group; provided that R is not a compound of Formula (a): wherein: R a is an alkyl group; R b is an aryl group; R c is hydrogen, a protecting group or an alkyl group; and R d is hydrogen, a protecting group or a SO 2 R e group, where R e is an alkyl group, which comprises: a) hydroxylating a compound of formula (1): wherein Y is a halo group, P 1 is hydrogen or a protecting group, and W is ═O or —OP 2 , in which P 2 is hydrogen or a protecting group, to provide a compound of formula (2): b) oxidizing the compound of formula (2) to provide a compound of formula (3): c) coupling the compound of formula (3) with a compound of formula (4): wherein Z is (PR 11 R 12 ) + X − or P(═O)R 11 R 12 , wherein X is an anion and R 11 and R 12 each independently is an alkyl, aryl, alkoxy or aryloxy group, to provide a compound of formula (5): d) when W is —OP 2 , removing any P 2 protecting group and oxidizing the compound of formula (5) to provide a compound of formula (6): and e) subjecting the compound of formula (5) when W is ═O, or compound of formula (6) to ring-opening, removal of any P 1 protecting groups, and optionally removing any additional protecting groups to provide a compound of formula (7).