Patent ID: 7186708

Claim:
A steroidal compound or a salt thereof having the following general formula: A—B—T c —Y—NO 2 (I) wherein: A=R—, wherein R is a steroidal drug radical as defined hereunder, B=—T B —X 2 —T BI — wherein T B is (CO); T BI is S, NH; X 2 is a bivalent bridging group such that the corresponding precursor of B, having the formula Z—T B —X 2 —T BI —Z′ in which Z and Z′ are independently H or OH, is selected from the following compounds: T c is (CO); Y has the following meanings: a linear or branched C 1 to C 20 alkylenoxy group or a cycloalkylene having from 5 to 7 carbon atoms, in the cycloalkylenic ring one or more carbon atoms can be substituted by heteroatoms, the ring can have side chains of R′ type, R′ being a linear or branched C 1 to C 20 alkyl; or wherein n3 is an integer from 0 to 3 and n3′ is an integer from 1 to 3, wherein R 1f =H, CH 3 and nf′ is an integer from 1 to 6; R has the following formula: wherein in substitution of the hydrogen atom of the CH groups or of the two hydrogen atoms of the CH 2 groups mentioned in the general formula, the following substituents can be present: in position 1–2: there may be a double bond; in position 3: there may be C═O, —OH; in position 4–5: there may be a double bond; in position 6: there may be —Cl, —F, —CH 3 ; in position 7: there may be —Cl, —OH; in position 9: there may be —Cl, —F; in position 11: there may be —OH, C═O, —Cl, —CH 3 ; in position 16: there may be —CH 3 , —OH; in position 17: there may be —OH, —CH 3 ; in position 16–17: there may be the following groups: R′″ and R′, equal or different from each other, are hydrogen or CH 3 ; and R″ is C(O)CH 2 O—.