Patent ID: 8414774

Claim:
An auto-injection system for high throughput screening of fluidic samples, the system comprising: a sample injection valve having: i. a first position that applies a reduced pressure to a sample sipper tube for aspirating a fluidic sample into the sample sipper tube, and ii. a second position that delivers the fluidic sample to a sample supply loop; a first column control valve coupled with a first chromatography column and a source of a first elution solvent, said first column control valve having: i. a first position that delivers the fluidic sample from the sample supply loop to said first chromatography column in a first direction, and ii. a second position that flows a first elution solvent over said first chromatography column in a second direction; and a second column control valve coupled with a sample analyzer, a source of a second elution solvent and a second chromatography column, and configured to facilitate a continuous flow of a second elution solvent to the sample analyzer, said second column control valve having: i. a first position that simultaneously delivers the fluidic sample from the sample supply loop to said second chromatography column in said first direction and delivers the second elution solvent to the sample analyzer, and ii. a second position that flows the second elution solvent over said second chromatography column in a second direction to deliver the fluidic sample and the second elution solvent to the sample analyzer.