Patent ID: 7777071

Claim:
A process for the preparation of intermediate compounds, wherein such intermediate compound has the Formula wherein A is —O—; m is 4; n is 4; p is 0; q is 0; B is —CR 1 R 2 ; D is —COOR 5 ; R 1 and R 2 are independently selected from the group consisting of hydrogen; C 1 -C 6 -alkyl; C 3 -C 6 cycloalkyl; C 2 -C 6 alkenyl; C 6 alkynyl; C 5 -C 10 aryl unsubstituted or substituted with C 1 -C 6 alkyl, hydroxyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, nitro, trihaloalkyl, carboxyl, C 1 -C 6 acyl, C 1 -C 6 hydroxyalkyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 acylamino, mercapto, C 1 -C 6 alkylthio, C 1 -C 6 mercaptoalkyl, and C 1 -C 6 alkoxycarbonyl; and C 5 -C 6 arylalkyl unsubstituted or substituted with C 1 -C 6 alkyl, hydroxyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, carboxyl, C 1 -C 6 acyl, C 1 -C 6 hydroxyalkyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, mercapto, C 1 -C 6 alkylthio, C 1 -C 6 mercaptoalkyl, and C 1 -C 6 alkoxycarbonyl; C 1 -C 6 carboxyalkyl; C 1 -C 6 acylamino; C 1 -C 6 sulfonatoalkyl; C 1 -C 6 sulfamylalkyl; and C 1 -C 6 phosphonatoalkyl; R 1 and R 2 may optionally be tethered together to form a 3- to 7-membered alicyclic ring; and R 5 is independently selected from the group consisting of hydrogen; C 1 -C 6 alkyl; and C 5 -C 6 arylalkyl unsubstituted or substituted with C 1 -C 6 alkyl; which comprises the following steps: where X=halogen or a leaving group; and R 1 and R 2 are defined as above; and where R 1 and R 2 are defined as above; and where R 1 , R 2 and R 5 are defined as above, and where R 1 , and R 2 and R 5 are defined as above is Et; and where R 1 , R 2 and R 5 are defined as above; and wherein PG is a protecting group chosen to be hydrogen, t-butyl, or a substituted or unsubstituted benzyl group of the formula wherein R 1 , R 2 and R 5 are as defined as above, and carnitine with a protecting group PG(5Λ) in Step 6 may be of D, L, or DL configuration; and where R 1 and R 2 are defined as above, and R 5 is C 1 -C 6 alkyl; or when R 5 is then Step 7 above yields where R 1 and R 2 are defined as above, and R 5 is hydrogen.