Patent ID: 8293479

Claim:
A method of monitoring and/or evaluating a ventilation regime in a mammal on a respirator, said method comprising: providing a biological sample comprising a fluid, cell, or tissue from the lung, trachea, or bronchi of said mammal; measuring the level of parathyroid hormone related protein (PTHrP) where a lower level of PTHrP, as compared to the level found in a comparable sample from a normal healthy mammal indicates that said ventilation regime is suboptimal; and where when said level of PTHrP is reduced thereby indicating that the ventilation regime is suboptimal, adjusting said ventilation regime to reduce tidal ventilation volume and/or ventilation pressure thereby reducing alveolar overdistension and increasing PTHrP production which reduces lipofibroblast to myofibroblast transdifferentiation in said mammal.