Patent ID: 7767646

Claim:
A method of identifying a compound which possesses (i) at least one aspirin activity selected from the group consisting of COX-1 inhibition and COX-2 inhibition, and (ii) no TAFIa-inhibition, comprising the steps of: a) exposing TAFIa to the test compound; b) measuring carboxypeptidase activity of TAFIa in the presence of and in the absence of the test compound; c) determining whether the test compound inhibits carboxypeptidase activity of TAFIa and/or inhibits TAFI activation by measuring the level of carboxypeptidase activity of TAFIa during exposure to the test compound; and d) determining whether at least one aspirin activity is retained by the test compound, thereby identifying a compound that possesses at least one aspirin activity but not TAFIa-inhibitory activity.