Patent ID: 7078565

Claim:
A compound of formula (I): wherein: R 1 is hydrogen; R 2 is (C 1-3 )alkyl; and R 3 is hydrogen or (C 1-3 )alkyl; or R 2 and R 3 together with the carbon to which they are attached form a (C 3-5 ) cycloalkyl group; or R 1 is (C 1-3 )alkyl; R 2 is hydrogen; and R 3 is hydrogen, or (C 1-3 )alkyl; R 4 and R 5 are independently selected from hydrogen, halogen, NC—, optionally substituted (C 1-6 )alkylCO, optionally substituted (C 1-6 )alkyl, optionally substituted (C 1-6 )alkoxy, optionally substituted (C 1-6 )alkylOCO—, and optionally substituted (C 1-6 )alkylNHCO—; provided that R 4 and R 5 are not both hydrogen; R 6 is hydrogen or halogen; Ar represents an optionally substituted aryl or an optionally substituted 5- or 6-membered aromatic heterocyclyl group containing up to 3 heteroatoms selected from N, O and S; or Ar represents an optionally substituted bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; wherein said optionally substituted Ar is substituted by 1 to 3 substituents independently selected from the group consisting of: phenyl optionally substituted by halogen; a 5- or 6-membered aromatic heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, optionally substituted by (C 1-4 )alkyl; halogen; hydroxy; oxo; cyano; nitro; (C 1-4 )alkyl; hvdroxy(C 1-4 )alkyl; (C 1-4 )alkoxy; hydroxy(C 1-4 )alkoxy; halo(C 1-4 )alkyl; halo(C 1-4 )alkoxy; aryl(C 1-4 )alkoxy; (C 1-4 )alkylthio; hydroxy(C 1-4 )alkyl; (C 1-4 )alkoxy(C 1-4 )alkyl; (C 3-6 )cycloalkyl(C 1-4 )alkoxy; (C 1-4 )alkanoyl; (C 1-4 )alkoxycarbonyl; (C 1-4 )alkylsulfonyl; (C 1-4 )alkylsulfonyloxy; (C 1-4 )alkylsulfonyl(C 1-4 )alkyl; arylsulfonyl; arylsulfonyloxy; arylsulfonyl(C 1-4 )alkyl; (C 1-4 )alkylsulfonamido; (C 1-4 )alkylamido; (C 1-4 )alkylsulfonamido(C 1-4 )alkyl; (C 1-4 )alkylamido(C 1-4 )alkyl; arylsulfonamido; arylcarboxamido; arylsulfonamido(C 1-4 )alkyl; arylcarboxamido(C 1-4 )alkyl; aroyl; aroyl(C 1-4 )alkyl; aryl(C 1-4 )alkanoyl group; and a group R x R y N—, R x OCO(CH 2 ) r , R x CON(R y )(CH 2 ) r , R x R y NCO(CH 2 ) r , R x R y N(CH 2 ) r O, R x R y NSO 2 (CH 2 ) r or R x SO 2 NR y (CH 2 ) r where each of R x and R y independently represents a hydrogen atom or a (C 1-4 )alkyl group or where appropriate R x R y forms part of a (C 3-6 )azacycloalkane or (C 3-6 )(2-oxo)azacycloalkane ring and r represents zero or an integer from 1 to 4; wherein when Ar is phenyl, two substituents on adjacent carbon atoms may, together with the ring to which they are attached, form a bicyclic or tricyclic heterocyclyl or carbocyclyl ring system, which may be optionally substituted by halogen or oxo; X is —CH 2 —, or a bond; Y is —NHCO—, or a bond; or a pharmaceutically acceptable salt or solvate thereof.