Patent ID: 7598398

Claim:
A compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein: each R 1 represents H or is independently selected from the group consisting of: a) OH, halo, CO 2 R a , C(O)NR b R c , NR b R c , CN or S(O) p R d ; and b) C 1-10 alkyl, C 2-10 alkenyl, OC 1-10 alkyl and OC 3-10 alkenyl, said groups being optionally substituted with: (1) 1-5 halo groups up to a perhaloalkyl group; (2) 1 oxo group; (3) 1-2 OH groups; (4) 1 phenyl ring, which is optionally substituted as follows: 1-5 halo groups up to perhalo, 1-3 C 1-10 alkyl or alkoxy groups, each being further optionally substituted with 1-5 halo up to perhalo; R 2 represents phenyl optionally substituted with 1-3 halo, C 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkyl and haloC 1-6 alkoxy groups; R 3 represents H, C 1-6 alkyl; 3 R 4 groups are present, 0-3 of which are C 1-8 alkyl, C 2-6 alkenyl, C 2-6 alkynyl or C 1-8 alkoxy groups, said groups being optionally substituted with: (1) 1-5 halo atoms up to perhaloalkyl; (2) 1 oxo group; (3) 1-2 OH groups; (4) 1-2 C 1-10 alkoxy groups, each optionally substituted with up to five halo atoms or a perhaloalkoxy, 1 OH or CO 2 R a group; (5) 1-2 Aryl groups, each optionally substituted as follows: (i) 1-5 halo atoms, (ii) 1 OH, CO 2 R a , CN, S(O) p R d , NO 2 or C(O)NR b R c group, (iii) 1-2 C 1-10 alkyl or alkoxy groups, each optionally substituted with: 1-5 halo atoms, up to perhaloalkyl; and 0-1 of which is Aryl optionally substituted as follows: (1) 1-3 halo atoms; (2) 1-2 OH, CO 2 R a , CN or S(O) p R d groups; (3) 1-3 C 1-8 alkyl groups optionally substituted with 1-5 halo groups, and (4) 1-3 C 1-10 alkoxy groups, the alkyl portion of which is optionally substituted with 1-5 halo groups, and the remainder are hydrogen atoms; R 5 represents H, halo, C 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkyl or haloC 1-6 alkoxy; G represents —CHR x — wherein R x represents H or C 1-8 alkyl; R a is H or C 1-10 alkyl, optionally substituted with phenyl, OH, OC 1-6 alkyl, CO 2 H, CO 2 C 1-6 alkyl and 1-3 halo groups; R b is H or C 1-10 alkyl; R c is H or is independently selected from: (a) C 1-10 alkyl, (b) Aryl or Ar—C 1-6 alkyl, each optionally substituted with 1-5 halos and 1-3 members selected from the group consisting of: CN, OH, C 1-10 alkyl and OC 1-10 alkyl, said alkyl and alkoxy being further optionally substituted with 1-5 halo groups up to perhalo; R d is C 1-10 alkyl, Aryl or Ar—C 1-10 alkyl; p is an integer selected from 0, 1 and 2, and and Z is selected from CH 2 CH 2 CO 2 R a , CH 2 CH(OH)CO 2 R a and 5-tetrazolyl.