Patent ID: 7202371

Claim:
A method of performing a catalytic asymmetric epoxidation comprising: reacting an alkene or cyclic alkene with catalytic amounts of a chiral bishydroxamic acid ligand and a metal, in the presence of an oxidation reagent, to produce a chiral epoxide, where the chiral bishydroxamic acid ligand has a structure I: where: R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxy, alkylamino, heterocyclyl, aryl, heteroaryl, and arylalkyl; or where R 1 and R 2 , together with the atom to which they are attached, form a substituted or unsubstituted ring selected from the group consisting of cycloalkyl, heterocyclyl, and aryl; or where R 4 and R 5 , together with the atom to which they are attached, form a substituted or unsubstituted ring selected from the group consisting of cycloalkyl, heterocyclyl, and aryl; R 7 , R 8 , R 9 , and R 10 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxy, alkylamino, heterocyclyl, aryl, heteroaryl, and arylalkyl; or where R 7 and R 9 , together with the atoms to which they are attached, form a substituted or non-substituted ring selected from the group consisting of cycloalkyl and heterocyclyl; -Z- is selected from the group consisting of —C(O)— and —S(O) 2 —.