Patent ID: 8288352

Claim:
A Conjugate Compound having the Formula Ia: or a pharmaceutically acceptable salt thereof; wherein: L- is a Ligand Unit; -A a -W w â€” is a Linker Unit (LU), wherein: -A- is a Stretcher Unit, a is 0 or 1, each â€”Wâ€” is independently an Amino Acid Unit, w is an integer ranging from 0 to 12, p is an integer ranging from 1 to about 20; and -D is a Drug Unit of the formula wherein independently at each location: R 2 is selected from the group consisting of -hydrogen, â€”C 1 -C 8 alkyl, â€”Oâ€”(C 1 -C 8 alkyl), -halogen, â€”NO 2 , â€”COOH, and â€”C(O)OR 11 ; each R 3 is selected independently from the group consisting of -hydrogen and â€”C 1 -C 8 alkyl; I is an integer ranging from 0-10; R 4 is selected from the group consisting of -hydrogen, â€”C 1 -C 8 alkyl, â€”C 3 -C 8 carbocycle, -aryl, â€”C 1 -C 8 alkyl-aryl, â€”C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), â€”C 3 -C 8 heterocycle and â€”C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); and R 5 is selected from the group consisting of â€”H and -methyl; or R 4 and R 5 jointly have the formula â€”(CR a R b ) n â€”, wherein R a and R b are independently selected from the group consisting of â€”H, â€”C 1 -C 8 alkyl and â€”C 3 -C 8 carbocycle, n is selected from the group consisting of 2, 3, 4, 5 and 6, and form a ring with the carbon atom to which they are attached; R 6 is selected from the group consisting of â€”H and â€”C 1 -C 8 alkyl; R 7 is selected from the group consisting of â€”H, â€”C 1 â€”C 8 alkyl, â€”C 3 -C 8 carbocycle, aryl, â€”C 1 -C 8 alkyl-aryl, â€”C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), â€”C 3 -C 8 heterocycle and â€”C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); each R 8 is independently selected from the group consisting of â€”H, â€”OH, â€”C 1 -C 8 alkyl, â€”C 3 -C 8 carbocycle, â€”O-alkyl-(C 1 -C 8 carbocycle) and â€”Oâ€”(C 1 -C 8 alkyl); R 9 is selected from the group consisting of â€”H and â€”C 1 -C 8 alkyl; R 10 is selected from the group consisting of aryl group and â€”C 3 -C 8 heterocycle; Z is selected from the group consisting of â€”Oâ€”, â€”Sâ€”, â€”NHâ€”, and â€”NR 12 â€” where R 12 is C 1 -C 8 alkyl or aryl; and R 11 is selected from the group consisting of â€”H, C 1 -C 8 alkyl, aryl, â€”C 3 -C 8 heterocycle, â€”(CH 2 CH 2 O) r â€”H, â€”(CH 2 CH 2 O) r â€”CH 3 , and â€”(CH 2 CH 2 O) r â€”CH 2 CH 2 C(O)OH; wherein r is an integer ranging from 1-10.