Patent ID: 8133905

Claim:
A compound of formula Ic: wherein: a is 0 or 1; R l is halo; b is 0 or 1; R 2 is halo; m is 0 or 1; Z 1 is selected from —C(O)N(R 4 )— and —N(R 4 )C(O)—, where R 4 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; n is 0 or 1; Ar 1 represents a phenylene group substituted with (R 5 ) p where p is 0 or an integer from 1 to 4 and each R 5 is independently selected from halo, hydroxy, (1-4C)alkyl, and (1-4C)alkoxy; q is 0 or 1; Z 2 is selected from —C(O)N(R 6 )— and —N(R 6 )C(O)—, where R 6 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; r is 0, 1 or 2; Y′ is selected from where: t is 0 or an integer from 1 to 3; v is 0 or an integer from 1 to 4; each R 10 independently represents fluoro or (1-4C)alkyl; R 11 is selected from hydrogen, —OH, -(1-4C)alkyleneOH, —C(O)NR 11a R 11b , and —CH 2 C(O)NR 11a R 11b , where R 11a and R 11b are independently selected from hydrogen, (1-4C)alkyl, hydroxy, (1-4C)alkoxy, (1-4C)alkyleneOR 11c , (3-6C)cycloalkyl, phenyl optionally substituted with hydroxy, and (1-4C)alkyleneC(O)NR 11d R 11e , where said (3-6C)cycloalkyl is unsubstituted or substituted with 1 or 2 (1-6C)alkyl or —NR 11d R 11e groups, and where each of R 11c , R 11d and R 11e is independently hydrogen or (1-4C)alkyl; or R 11a is taken together with R 11b to form a 3-7 membered ring, optionally substituted with hydroxyl; R 12 and R 13 are taken together to form a ring selected from piperazinone, morpholine, and piperazine; and said piperazine is substituted with (R 13c ) w where w is 0 or an integer from 1 to 3 and each R 13c is independently selected from (1-4C)alkyl, phenyl, and benzyl, optionally substituted with 1 to 5 fluoro substituents, or two R 13c groups are joined to form (1-3C)alkylene; wherein each alkyl and alkoxy group in R 5 is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.