Patent ID: 8386189

Claim:
An article of manufacture for analysis of a decoy protein to determine whether a decoy protein has a structure of a native globular protein, comprising: a computer-readable medium having computer-readable code embodied thereon, the computer-readable code comprising: a step to determine a normalized second-order hydrophobic moment profile for the decoy protein; a step to use the normalized second-order hydrophobic moment profile to determine a scoring function for analysis of the decoy protein; a step to use the scoring function to generate a score for the decoy protein, wherein the scoring function comprises S H =∫ 0 1 |{tilde over (H)} 2 |ds, wherein the score comprises an integral of an area under the normalized second-order hydrophobic moment profile of the decoy protein, and wherein the score measures a prominence of a hydrophobic core and a prominence of a hydrophilic exterior of the decoy protein; and a step to use the score of the decoy protein to determine whether the decoy protein has a structure of a native globular protein.