Patent ID: 7769419

Claim:
A method of measuring changes in an apparent depth of the anterior chamber of an eye, the anterior chamber being defined by a first interface between the cornea and the aqueous humor of the eye and a second interface between the aqueous humor and the ocular lens of the eye, the method comprising the steps of: a) focusing light to a measurement location proximate or within the eye; b) scanning the measurement location through the anterior chamber; c) detecting reflected light from the measurement location as the measurement location passes through the first and the second interfaces and generating a signal representative of the detected light; and using a processor: d) deriving from the signal apparent positions of the first and the second interfaces and, therefrom, the apparent depth of the anterior chamber; e) comparing the derived apparent depth with a previous reference measurement of the apparent depth, so as to determine a change in the refractive index of the aqueous humor; and f) calculating a measure of change in concentration of an analyte of interest in the aqueous humor from the determined change of refractive index.