Patent ID: 7585522

Claim:
A method for providing a secondary boosting immune response in a mammal to a specific antigen of a non-enteric pathogen (NEPA), the pathogen being a pathogen that invades through a breach in the skin and that does not itself enterically raise a primary protective immune response in mammals in the absence of prior acquired immunity to the pathogen, said method comprising: rendering the mammal immunoreceptive to the NEPA by prior immunization against a non-enteric pathogen by injecting the mammal with a vaccine containing the NEPA to render an immunoreceptive mammal; and then orally administering the NEPA to the immunoreceptive mammal by feeding the mammal with transgenic potato containing the NEPA expressed in the potato to enterically cause a secondary immune response to the oral administration specific to the NEPA stronger than would be caused by orally administering the NEPA in the absence of the prior immunization by injection.