Patent ID: 8653272

Claim:
A compound represented by formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein Alk l represents an optionally substituted straight or branched C 1-3 alkylene chain; L 1 represents oxygen, sulfur, NR 2 or a covalent bond; Y represents an optionally substituted mono- or bicyclic heteroaryl group containing at least one nitrogen atom; R 1 represents a group of formula (a): in which the asterisk (*) represents the point of attachment of the ring A to the remainder of the molecule; A represents a saturated, partially saturated or unsaturated 4-, 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2, 3 or 4 heteroatoms selected from N, O and S, but containing no more than one O or S atom; R 1a , R 1b and R 1c independently represent hydrogen, halogen, cyano, nitro, oxo, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, C 3-7 heterocycloalkyl (optionally substituted by C 1-6 alkyl), heteroaryl, trifluoromethyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, C 2-6 alkylcarbonylamino, C 2-6 alkoxycarbonylamino, C 1-6 alkylsulfonylamino, formyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di(C 1-6 ) alkylaminocarbon, aminosulfonyl, C 1-6 alkylaminosulfonyl or di (C 1-6 ) alky laminosulfonyl; R 2 represents hydrogen or C 1-6 alkyl; and R y and R z independently represent hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 3 - 7 cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkyl-(C 1-6 ) alkyl, heteroaryl, heteroaryl(C 1-6 )alkyl, hydroxy, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulphinyl, C 1-6 alkylsulphonyl, C 2-6 alkylcarbonyl, amino, C 1-6 alkylamino, di(C 1-6 ) -alkylamino, halogen, cyano or trifluoromethyl.