Patent ID: 7498319

Claim:
A compound of formula I wherein: R is (C 3-5 )alkyl, di(C 1-4 )alkoxymethyl, (C 3-6 )cycloalkyl(C 1-4 )alkyl or benzyl optionally substituted in the aromatic ring by one to three radicals selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy and halo, R 1 is hydrogen or hydroxy, R 2 is a group of formula wherein R a is (C 1-4 )alkoxy, and R 3 is hydrogen or (C 1-4 )alkyl, or a salt thereof; wherein the compound of formula I is selected from the group consisting of: {3-[(6-methoxy-3-pyridylmethyl)-amino]-2-(S)-hydroxy-propyl}-(cyclohexylmethyl)-phosphinic acid; {3-[(2-methoxy-4-pyridylmethyl)-amino]-2-(S)-hydroxy-propyl}-(cyclohexylmethyl)-phosphinic acid; {3-[(6-methoxy-3-pyridylmethyl)-amino]-2-(S)-hydroxy-propyl}-(benzyl)-phosphinic acid; {3-[(2-methoxy-4-pyridylmethyl)-amino]-2-(S)-hydroxy-propyl}-(benzyl)phosphinic acid; {3-[6-methoxy-3-pyridylmethyl)-amino]-2-(S)-hydroxy-propyl}-(diethoxy-methyl)-phosphinic acid; {3-[2-methoxy-4-pyridylmethyl)-amino]-2-(S)-hydroxy-propyl}-(diethoxy-methyl)-phosphinic acid; {2-(S)-hydroxy-3-[6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-amino]-propyl}-(cyclohexylmethyl)-phosphinic acid; {2-(S)-hydroxy-3-[(2-oxo-1,2-dihydro-pyridin-4-ylmethyl)amino]-propyl}-(cyclohexylmethyl)-phosphinic acid; {2-(S)-hydroxy-3-[(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-amino]-propyl}-(benzyl)-phosphinic acid; and {2-(S)-hydroxy-3-[(2-oxo-1,2-dihydro-pyridin-4-ylmethyl)-amino]-propyl}-(benzyl)-phosphinic acid.