Patent ID: 8367719

Claim:
A chemical entity selected from compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I): wherein R 1 is H; —CH 2 CO 2 H; —(CH 2 ) 1-3 CO 2 C 1-4 alkyl; —CH 2 -aryl substituted with CO 2 R a ; —C(O)C 1-4 alkyl; —C(O)C(R a )(R b )—OH; —C(O)C(R a )(R b )—F; —C(O)C(R a )(R b )—CF 3 ; —C(O)C(R a )(R b )—OC 1-4 alkyl; —C(O)C(R a )(R b )—N(R c )R d ; —C(O)N(R c )(R d ); —C(O)-cycloalkyl; —C(O)-(monocyclic heteroaryl) optionally substituted with methyl; —C(O)-(monocyclic heterocycloalkyl) optionally substituted with methyl or —CO 2 C 1-4 alkyl; —SO 2 C 1-4 alkyl; —SO 2 NH 2 ; —SO 2 -cycloalkyl; or —SO 2 — (monocyclic heteroaryl) optionally substituted with methyl; where R a and R b are each independently H or methyl; or R a and R b taken together with the carbon to which they are attached form a saturated monocyclic cycloalkyl or heterocycloalkyl ring, optionally substituted with one or two methyl groups; R c is H; and R d is H, C 1-4 alkyl, —CO 2 C 1-4 alkyl, —C(O)CF 3 , or —(CH 2 ) 0-1 -monocyclic heteroaryl optionally substituted with one or two methyl groups; X is N or >CHNR e —; where R e is H or methyl; Z is N or >CHNR f —; where R f is H or methyl; and at least one of X and Z is N; m, n, p, and q are independently 0, 1, or 2 wherein the sum (m+n+p+q) may not exceed 6; and provided that when the sum of m, n, p, and q is 2, then Y is a bond, —CH 2 —, or —CH 2 CH 2 —; and when the sum of m, n, p, and q is 4, 5 or 6, then Y is a bond; Q is O or CH 2 , and said Q is linked at the “a” or “b” position of the phenyl ring; D is O; R 2 is H, CH 3 , OCH 3 , halo, OH, NH 2 , or CN; R 3 is H or F; and A is —CH 2 —, —CH 2 CH 2 —, or —OCH 2 CH 2 —.