Patent ID: 8003128

Claim:
A method of preparing a drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the blood brain barrier of the mammal, the method comprising the steps of: solubilizing poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), at least one pharmacologically active substance, and a lipid compound selected from the group of lipid compounds consisting of cetyl phosphate, potassium cholesteryl sulphate and tocopheryl succinate, in an organic solvent to obtain an organic phase; pouring the organic phase into an aqueous solution containing TPGS to form a mixture; emulsifying the mixture to obtain a primary emulsion; homogenizing the primary emulsion; removing the organic solvent from the primary emulsion to form a nanosuspension comprising drug-loaded nanoparticles; and filtering the resulting nanosuspension comprising drug-loaded nanoparticles.