Patent ID: 8034945

Claim:
A 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivative according to Formula I, wherein R 1 is (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl; R 2 is halogen, (1-4C)alkoxy, fluorinated (1-4C)alkoxy, (1-4C)alkyl, or fluorinated (1-4C)alkyl; or R 2 may be H when R 3 is R 9 ,R 10 -aminosulfonyl; R 3 is OH, NO 2 , CN, fluorinated (1-4C)alkoxy, (1-4C)alkoxy(2-4C)alkoxy, hydroxy(2-4C)alkoxy, (1-4C)alkoxycarbonyl, (3-4C)alkenyloxycarbonyl, (1-4C)alkoxycarbonyloxy, (3-4C)alkenyloxycarbonyloxy, R 7 ,R 8 -amino, R 9 ,R 10 -amino, R 9 ,R 10 -aminocarbonyl, R 9 ,R 10 -aminosulfonyl or phenyl(1-4C)alkoxy, wherein the phenyl ring is optionally substituted with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (di)(1-4C)alkylamino; R 4 is R 11 -phenyl or R 11 -(2-5C)heteroaryl, wherein the phenyl or heteroaryl group is optionally further substituted with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluromethyl, cyano, (1-4C)alkyl, (1-4C)alkylthio, (1-4C)alkoxy, (2-4C)alkenyl, (2-4C)alkynyl; R 7 is H, (1-4C)alkyl; R 8 is (1-4C)alkylsulfonyl, (1-4C)alkylcarbonyl, (2-4C)alkenylcarbonyl, (3-6C)cycloalkylcarbonyl, (1-4C)alkoxycarbonyl, (3-4C)alkenyloxycarbonyl, (1-4C)alkoxy(1-4C)alkylcarbonyl, (3-4C)alkenyloxy(1-4C)alkylcarbonyl phenylcarbonyl, (2-5C)heteroarylcarbonyl, phenyl(1-4C)alkylcarbonyl, (2-5C)heteroaryl(1-4C)alkylcarbonyl, wherein the phenyl ring or the heteroaromatic ring is optionally substituted with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (di)(1-4C)alkylamino; R 9 and R 10 are independently selected from H, (1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-4C)alkyl and (1-4C)alkoxy(2-4C)alkyl; or R 9 and R 10 may be joined in a (4-6C)heterocycloalkenyl ring or a (2-6C)heterocycloalkyl ring, optionally substituted with one or more (1-4C)alkyl substituents; R 11 is H, (1-6C)alkoxycarbonyl, R 12 ,R 13 -amino, (1-6C)alkylcarbonyl, (1-6C)alkylsulfonyl, R 14 -oxy, R 14 ,R 15 -amino, R 14 ,R 15 -aminocarbonyl, R 14 ,R 15 -aminosulfonyl; R 12 is H, (1-4C)alkyl; R 13 is (1-4C)alkylsulfonyl, (1-4C)alkylcarbonyl, (3-6C)cycloalkylcarbonyl, (1-4C)alkoxycarbonyl, (3-4C)alkenyloxycarbonyl, (di)(1-4C)alkylamino-(1-4C)alkylcarbonyl, (2-6C)heterocycloalkyl(1-4C)alkylcarbonyl, (4-6C)heterocyclo-alkenyl(1-4C)alkylcarbonyl or (1-4C)alkoxy(1-4C)alkylcarbonyl; R 14 and R 15 are independently selected from H, (1-6C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-4C)alkyl, hydroxy(2-4C)alkyl, amino(2-4C)alkyl, (1-4C)alkoxy(2-4C)alkyl, (di)(1-4C)alkylamino(2-4C)alkyl, (2-6C)heterocycloalkyl(2-4C)alkyl, (4-6C)heterocycloalkenyl(2-4C)alkyl, phenyl(1-4C)alkyl and (2-5C)heteroaryl(1-4C)alkyl; X is O or R 16 —N; Y is CH 2 , C(O) or SO 2 ; Z is CN or NO 2 ; R 16 is H, (1-4C)alkyl, (1-4C)alkylcarbonyl; or a pharmaceutically acceptable salt thereof.