Patent ID: 7608582

Claim:
A delivery vehicle for controlled and/or localized release of therapeutic molecules, said delivery vehicle comprising a channel protein, the channel protein modified with a pH-responsive or light-responsive compound of the general formula Q-C or P-C, wherein Q is a chargeable group selected from the group consisting of Q 1 , Q 2 , and Q 3 as depicted in the following, wherein R 1 , R 2 and R 3 are independently selected from the group consisting of H, methyl (Me), ethyl (Et), propyl (Pr), isopropyl (iPr), phenyl (Ph), and benzyl (Bn), wherein P is a photocleavable chargeable group selected from the group consisting of P 1 , P 2 , P 3 , P 4 , P 5 , P 6 , P 7 and P 8 as depicted in the following, wherein R 1 and R 2 are independently selected from the group of H, Me, Et, Pr, iPr, Ph and Bn and wherein R 3 ═H or OMe, and wherein C is a coupling group selected from the group consisting of C 1 , C 2 , C 3 , C 4 , C 5 and C 6 as depicted in the following, wherein X═Br or I.