Patent ID: 8404745

Claim:
A method of enhancing the rate of permeation of cetylated fatty esters through the skin comprising steps: a. Topically applying to a portion of skin a composition comprising: i. four or more cetylated fatty acid esters, said cetylated esters are present in amounts ranging from 4-40%, and are selected from the group consisting of cetyl oleate, cetyl palmitate, cetyl myristoleate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms; and ii. one or more polar solvents present in amounts ranging from 5-30%, wherein the solvents are selected from the group consisting of 1,2,4-butane triol, dimethicone copolyol, ethylene glycol, glycerol, glyceryl monostearate, 1,2,6-hexane triol, propylene glycol ether of methyl glucose or sorbitol, PEG 40 hydrogenated caster oil, polyethylene glycol and propylene glycol; and b. Applying phonophoresis or ionophoresis to the same portion of skin; wherein step b can optionally be performed before step a.