Patent ID: 7744923

Claim:
A method of simultaneous precipitation of material within a plurality of containers using an antisolvent gas, said method comprising: locating a plurality of containers within a pressurizable chamber, each container being at least partially open to the atmosphere within the chamber and having a quantity of a liquid therein containing material to be precipitated; heating and pressurizing said chamber with said containers therein; introducing an antisolvent gas into the chamber and establishing temperature and pressure conditions within said chamber that are at near-supercritical or supercritical conditions for said antisolvent gas thereby forming near-supercritical or supercritical, respectively, antisolvent; then with an ultrasonic device remote from the liquid containing material to be precipitated, generating ultrasonic energy waves within said near-supercritical or supercritical antisolvent in said chamber and propagating said waves through said near-supercritical or supercritical antisolvent in the interior of said chamber and into said containers, in order to mix said liquid and said near-supercritical or supercritical antisolvent, supersaturate the liquid with the material to be precipitated, dissolve the liquid in the near-supercritical or supercritical antisolvent, and precipitate the material as particles in said containers; and removing said near-supercritical or supercritical antisolvent and liquid from said chamber and said containers, thereby leaving said particles in said containers.