Patent ID: 8912186

Claim:
A compound of formula I: wherein, Y is C; W is C; X 1 taken together with X 3 forms a double bond between Y and W; X 2 is Q 2 ; X 3 taken together with X 1 forms a double bond between W and Y; Q 2 H; Q 1 is COOH or COOR 1 ; P is absent and Q 1 is bonded to Y by a single bond; V is CH 2 ; U is CH 2 ; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are at each occurrence in the compound of formula I C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, optionally substituted heteroaryl or optionally substituted aryl; Ar 2 is a phenyl ring, a naphthyl ring, or an indenyl ring carrying 0-4 substituents R 12 ; Ar 1 is an aryl or a heteroaryl group selected from the group consisting of phenyl, naphthyl, indolyl, benzofuranyl, benzothiophenyl, isoindolyl, indazolyl, benzo[d]isothiazolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, isoquinolinyl, quinolinyl, phthalazinyl, quinoxalinyl, quinazolinyl, cinnolinyl, and naphthoimidazolyl, wherein the aryl group or the heteroaryl group carry 1-4 substituents R 12 , and wherein any stable S or N ring atom of said heteroaryl group may be substituted with oxo; R 12 is at each occurrence in the compound of formula I selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted aryl, —F, —Cl, —Br, —I, —CF 3 , —Z—OR 13 , —Z—NO 2 , —Z—NR 13 OOR 14 , —Z—NR 13 R 14 , —Z—SR 13 , —Z—COOR 13 , —Z—CONR 13 R 14 , —Z—C(O)SR 13 , —Z—C(O)NR 13 OR 14 , —Z—CN, —Z—COR 13 , —Z—COOCH 2 C(O) R 13 , —Z—COOCH 2 C(O)NR 13 R 14 , —Z—SOR 13 , —Z—SO 2 R 13 , —Z—SO 2 NR 13 R 14 , —Z—P(O)(OR 13 )OR 14 and —Z-tetrazol-5-yl; Z is a single bond or a bivalent spacer group; R 13 and R 14 are at each occurrence in the compound of formula I independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, optionally substituted heteroaryl and optionally substituted aryl, or a pharmaceutically acceptable salt, solvate, diastereomer, enantiomer, tautomer or racemate thereof.