Patent ID: 7087758

Claim:
A compound of Formula I: wherein: R 1 is selected from the group consisting of: —NH—C 1-6 alkyl, —NH—C 3-7 cycloalkyl, —NH—C 3-7 cycloheteroalkyl, —NH-aryl, —NH-Het, —O—C 1-6 alkyl, —O—C 3-7 cycloalkyl, —O—C 3-7 cycloheteroalkyl, —O-aryl, —O-Het, —S—C 1-6 alkyl, —S—C 3-7 cycloalkyl, —S—C 3-7 cycloheteroalkyl, —S-aryl, —S-Het, —C 3-7 cycloalkyl and —C 3-7 cycloheteroalkyl; R 2 is selected from the group consisting of: —CO 2 H, —CONH 2 , and —CO 2 R′; R 3 is selected from the group consisting of: —H, —OH, —C 1-6 alkyl, —C 3-7 cycloalkyl, aryl, Het, —O—C 1-6 alkyl, —O—C 3-7 cycloalkyl, —O-aryl, —O-Het, —S—C 1-6 alkyl, —S—C 3-7 cycloalkyl, —S-aryl, —S-Het, —NH—C 1-6 alkyl, —NH—C 3-7 cycloalkyl, —NH-aryl, —NH-Het and halogen; R 4 is selected from the group consisting of: —H, —C 1-6 alkyl, —C 3-7 cycloalkyl, aryl, Het, —O—C 1-6 alkyl, —O—C 3-7 cycloalkyl, —O-aryl, —O-Het, —S—C 1-6 alkyl, —S—C 3-7 cycloalkyl, —S,-aryl, —S-Het, —NH—C 1-6 alkyl, —NH—C 3-7 cycloalkyl, —NH-aryl, —NH-Het and halogen; R 3 and R 4 can form a 5 to 7 membered ring comprising 0–3 heteroatoms independently selected from the group consisting of: O, N, and S; R 5 is selected from the group —H and halogen; R′ is selected from the group consisting of: —C 1-6 alkyl, —C 3-7 cycloalkyl, and —C 3-7 cycloheteroalkyl; and R″ is selected from the group consisting of: —C 1-6 alkyl, —C 3-7 cycloalkyl, —C 3-7 cycloheteroalkyl, aryl, and Het; or a pharmaceutically acceptable salt, hydrate or solvate thereof.