Patent ID: 8846681

Claim:
A method of inhibiting the activity of AKT in a mammal, said method comprising administering to said mammal an effective amount of a compound of the Formula: and enantiomers and salts thereof, wherein: R 1 and R 1a are independently selected from H, Me, Et, CH═CH 2 , CH 2 OH, CF 3 , CHF 2 or CH 2 F; R 2 and R 2a are independently selected from H or F; R 5 is H, Me, Et, or CF 3 ; A is wherein G is phenyl optionally substituted with one to four R 9 groups or a 5-6 membered monocyclic or 9 member bicyclic heteroaryl optionally substituted by a halogen; R 6 and R 7 are independently H, (C 3 -C 6 cycloalkyl)-(CH 2 ), (C 3 -C 6 cycloalkyl)-(CH 2 CH 2 ), V—(CH 2 ) 0-1 wherein V is a 5-6 membered heteroaryl, W—(CH 2 ) 1-2 wherein W is phenyl optionally substituted with F, Cl, Br, I, OMe, CF 3 or Me, C 3 -C 6 -cycloalkyl, hydroxy-(C 3 -C 6 -cycloalkyl), fluoro-(C 3 -C 6 -cycloalkyl), CH(CH 3 )CH(OH)phenyl, 4-6 membered heterocycle optionally substituted with F, OH, cyclopropylmethyl, C 1 -C 3 alkyl or C(═O)(C 1 -C 3 alkyl), or C 1 -C 6 -alkyl optionally substituted with one or more groups independently selected from OH, oxo, O(C 1 -C 6 -alkyl), CN, F, NH 2 , NH(C 1 -C 6 -alkyl), N(C 1 -C 6 -alkyl) 2 , tetrahydropyranyl, tetrahydrofuranyl, morpholinyl, oxetanyl, piperidinyl, and pyrrolidinyl, or R 6 and R 7 together with the nitrogen to which they are attached form a 3-6 membered heterocyclic ring optionally substituted with one or more groups independently selected from OH, halogen, oxo, CF 3 , CH 2 CF 3 , CH 2 CH 2 OH, C(═O)CH 3 , and (C 1 -C 3 )alkyl; R a and R b are H, or R a is H, and R b and R 6 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having one or two ring nitrogen atoms; R c and R d are H or Me, or R c and R d together with the atom to which they are attached form a cyclopropyl ring; R 8 is H, Me, or OH, or R 8 and R 6 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having one or two ring nitrogen atoms; each R 9 is independently halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, O—(C 1 -C 6 -alkyl), CF 3 , OCF 3 , S(C 1 -C 6 -alkyl), CN, OCH 2 -phenyl, CH 2 O-phenyl, NH 2 , NO 2 , NH—(C 1 -C 6 -alkyl), N—(C 1 -C 6 -alkyl) 2 , piperidine, pyrrolidine, CH 2 F, CHF 2 , OCH 2 F, OCHF 2 , OH, SO 2 (C 1 -C 6 -alkyl), C(O)NH 2 , C(O)NH(C 1 -C 6 -alkyl), and C(O)N(C 1 -C 6 -alkyl) 2 ; and m, n and p are independently 0 or 1.