Patent ID: 8268826

Claim:
A compound of Formula I: or pharmaceutically acceptable salt thereof, wherein: R 1 is heteroaryl optionally substituted by one or more R 6 ; R 2 is H, halo, cyano, nitro, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, C 3 -C 7 cycloalkyl, heterocycloalkyl, SOR 7 , SO 2 R 7 , COR 8 , OR 9 , SR 9 , COOR 9 , NR 10 R 11 or NR 10 COR 8 ; R 3 is F, Cl, Br, I, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy or heteroaryl; R 4 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 1 -C 6 haloalkyl; R 5 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 1 -C 6 haloalkyl; R 6 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, amino, (C 1 -C 6 alkyl)amino or di(C 1 -C 6 alkyl)amino; R 7 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, aryl, heteroaryl, C 3 -C 7 cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, (C 3 -C 7 cycloalkyl)alkyl, heterocycloalkylalkyl, or NR 12 R 13 ; R 8 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, aryl, heteroaryl, C 3 -C 7 cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, (C 3 -C 7 cycloalkyl)alkyl, heterocycloalkylalkyl, or NR 12 R 13 ; R 9 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, alkoxyalkyl, haloalkoxyalkyl, aryloxyalkyl, heteroaryloxyalkyl, cycloalkyloxyalkyl, heterocycloalkyloxyalkyl, aryl, heteroaryl, C 3 -C 7 cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl; (C 3 -C 7 cycloalkyl)alkyl or heterocycloalkylalkyl; R 10 and R 11 are each, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, aryl, heteroaryl, C 3 -C 7 cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl; (C 3 -C 7 cycloalkyl)alkyl or heterocycloalkylalkyl; or R 10 and R 11 together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R 12 and R 13 are each, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, aryl, heteroaryl, C 3 -C 7 cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl; (C 3 -C 7 cycloalkyl)alkyl or heterocycloalkylalkyl; or R 12 and R 13 together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group; r is 1, 2 or 3.