Patent ID: 7179826

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is sulfur; X is CR; each occurrence of R is independently hydrogen, an optionally substituted C 1-6 aliphatic group, or Ar; Z 1 is nitrogen or CR x ; wherein R x is —R, halogen, —N(R) 2 , —NO 2 , —CN, —CO 2 R, —OR, or —SR; wherein two R bound to the same nitrogen atom may be taken together with that nitrogen atom to form a five or six membered heterocyclic or heteroaryl ring having one to two additional heteratoms independently selected from oxygen, nitrogen, or sulfur; Z 2 is CR y ; wherein R y is —R 1 , —CN, halogen, —NO 2 , -Ar, -T-Ar, or -T-R; or R x and R y are taken together to form a five to seven membered optionally substituted partially unsaturated or fully unsaturated ring having zero to two heteroatoms independently selected from oxygen, sulfur, or nitrogen, wherein: each substitutable ring nitrogen of the ring formed by R x and R y is optionally substituted; R 1 is hydrogen or an optionally substituted C 1-6 aliphatic group; each Ar is independently a three to six membered optionally substituted heterocyclic ring having one to two heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a five or six membered optionally substituted aryl ring having zero to three heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: Ar is optionally fused to a five or six membered optionally substituted partially unsaturated, or fully unsaturated ring having zero to two heteroatoms independently selected from nitrogen, oxygen, or sulfur; T is a C 1-4 alkylidene chain wherein one methylene unit of T is optionally replaced by —O—, —S—, —C(O)—, —CO 2 —, —NR—, —NRC(O)—, —NRC(O)NR—, —OC(O)NR—, —NRCO 2 —, —SO 2 NR—, —NRSO 2 —, or —NRSO 2 NR—; Q is —N(R′)—, —S—, —O—, —C(R′) 2 —, or a valence bond; wherein each R′ is independently hydrogen or C 1-6 aliphatic; and Ring D is a five or six membered optionally substituted monocyclic aryl ring having zero to two heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an eight to ten membered optionally substituted partially unsaturated or fully unsaturated bicyclic ring having zero to four heteroatoms independently selected from nitrogen, oxygen, or sulfur.