Patent ID: 8552180

Claim:
A method for separating an amide from an amino acid ionic liquid in Beckman rearrangement reaction, comprising the steps of: catalyzing a ketoxime in the Beckman rearrangement reaction in the presence of the amino acid ionic liquid, the organic solvent and a Bronsted acid to produce the amide; and providing a polar solvent and an extracting agent to the amino acid ionic liquid, so as to separate the amide from the amino acid ionic liquid, wherein the amino acid ionic liquid comprises an anion selected from an inorganic acid group and an organic acid group of the Bronsted acid, and a cation of formula (I): wherein R 1 and R 2 are independently hydrogen or C 1-8 alkyl, and R 3 is hydrogen, cycloimino, or C 1-8 alkyl, wherein the C 1-8 alkyl is unsubstituted or substituted by a substituent selected from the group consisting of hydroxyl, carboxyl, guanidino, amino, amido, ester group, sulfonate, chlorosulfinyl, hydroxyphenyl, C 1-8 alkylthio, thiol, C 6-10 aryl and 5- to 10-membered heteroaryl.