Patent ID: 8884027

Claim:
A melampomagnolide B derivative compound of the formula (I): wherein: R is selected from —P(O)(OR 1 )(OR 2 ); —CH 2 OP(O)(OR 1 )(OR 2 ); —C(O)(CR 3 R 4 ) n X; —CH 2 OC(O)(CR 3 R 4 ) n X; —C(O)O(CR 3 R 4 ) n X; —C(O)NHCH 2 CH 2 NH 2 ; —C(O)NHCH 2 (CH 2 ) 2 NH 2 ; —C(O)NHCH 2 (CH 2 ) 3 NH 2 ; —C(O)NHCH 2 (CH 2 ) 4 NH 2 and —C(O)(CH 2 ) m C(O)NH(CR 3 R 4 ) n X; R 1 , R 2 are independently selected from H; Na; K; NH 3 ; unsubstituted C 1 -C 12 alkyl, optionally substituted alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, and aryl; R 3 , R 4 are independently selected from H, NR 5 R 6 , OR 1 , SR 1 , S(O)R 1 , SO 2 R 1 , optionally substituted C 1 -C 12 alkyl, alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, and aryl; R 5 , R 6 are independently selected from H; optionally substituted C 1 -C 12 alkyl, alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, aryl; —CO 2 C 1 -C 12 alkyl, CO 2 alkenyl, CO 2 alkynyl, CO 2 heterocycloalkyl, CO 2 heteroaryl, CO 2 cycloalkyl, CO 2 aryl; and C 1 -C 12 alkylamino; or R 5 and R 6 optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms; X is selected from NR 5 R 6 , NHC(O)R 2 ; NHC(O)OR 2 ; OR 1 , SR 1 , halo, trifluoromethyl, optionally substituted C 1 -C 12 alkyl, alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, and aryl; n is 1-6, m is 1-2; or a pharmaceutically acceptable salt or ester thereof.