Patent ID: 7144917

Claim:
A method for treating cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, imflammation or an autoimmune disease in a mammal inflicted with or at risk thereof, the method comprising administering to the mammal in need of such treatment an effective amount of a compound of formula (I): wherein A—X—M is a hydrophobic group that can fit into the deep hydrophobic pocket of a matrix metalloproteinase and has a favorable interaction with the matrix metalloproteinase; D is O, S, (C 1 –C 6 )alkyl, a direct bond, SO 2 , SO, C(═O)NR, C(═O)O, NRC(═O), or OC(═O); E is a direct bond, (C 1 –C 6 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 6 )alkenyl, or (C 2 –C 6 )alkynyl, wherein any alkyl, cycloalkyl, alkenyl, or alkynyl of E is optionally substituted with one or more (C 1 –C 6 )alkyl, hydroxy, (C 1 –C 6 )alkoxy, cyano, nitro, halo, SR, NRR, or COOR, wherein each R is independently H or (C 1 –C 6 )alkyl; J is S or O; G, T, and Q are each independently H, (C 1 –C 6 )alkyl, or cyano; or a pharmaceutically acceptable salt thereof.