Patent ID: 8648074

Claim:
A compound of Formula (I): or a salt thereof, wherein: Z′ is CH 2 or C(O); Z″ is CH 2 ; one of R 1 and R 2 is hydrogen and the other of R 1 and R 2 is G 1 -L 1 -; L 1 is —C(R c )(R d )—, —C(O)NR a —, —NR a C(O)—, —S(O) 2 NR a —, —NR a S(O) 2 —; —NR a —, or —O—; G 1 is C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, Ar 1 , —(CR a R b ) j —Ar 1 , —CH(Ar 1 ) 2 , or —Ar 1 -G a ; R a and R b , at each occurrence, are each independently hydrogen, C 1 -C 4 -alkyl, or C 1 -C 4 -haloalkyl; R c and R d are each independently hydrogen, hydroxy, C 1 -C 4 -alkyl, or C 1 -C 4 -haloalkyl; j is 1, 2, 3, 4, or 5; Ar 1 is, at each occurrence, independently aryl or heteroaryl, wherein Ar 1 is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, halogen, cyano, —NO 2 , —OR s , —OC(O)R s , —OC(O)N(R s )(R t ), —SR s , —S(O)R s , —S(O) 2 R s , —S(O) 2 N(R s )(R t ), —C(O)R s , —C(O)OR s , —C(O)N(R s )(R t ), —N(R s )(R t ), —N(R s )C(O)R t , —N(R s )C(O)O(R t ), —N(R s )S(O) 2 (R t ), C 1 -C 4 -cyanoalkyl, and C 1 -C 4 -haloalkyl; R s and R t are, at each occurrence, independently hydrogen, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, or C 1 -C 4 -haloalkyl; G a is C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkenyl, heterocyclyl, or heteroaryl, wherein the C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkenyl, heterocyclyl, or heteroaryl are unsubstituted or substituted with 1, 2, or 3 C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, or halogen; L 2 is —S(O) 2 —, —S(O) 2 CH 2 —, or —S(O)—; G 2 is C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, C 3 -C 8 -cycloalkyl, Ar 2 or Ar 3 ; Ar 2 is aryl or heteroaryl, wherein Ar 2 is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, halogen, cyano, —NO 2 , -alkyl-OR u , —OC(O)R u , —OC(O)N(R u )(R v ), —SR u , —S(O)R u , —S(O) 2 R u , —S(O) 2 N(R u )(R v ), —C(O)R u , —C(O)OR u , —C(O)N(R u )(R v ), —N(R u )(R v ), —N(R u )C(O)R v , —N(R u )C(O)O(R v ), —N(R u )S(O) 2 (R v ), C 1 -C 4 -cyanoalkyl, C 1 -C 4 -haloalkyl, and -G b ; G b is C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkenyl, heterocyclyl, aryl, or heteroaryl, wherein the C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkenyl, heterocyclyl, aryl, or heteroaryl are unsubstituted or substituted with 1, 2, or 3 C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, or halogen; R u and R v are, at each occurrence, independently hydrogen, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, or C 1 -C 4 -haloalkyl; Ar 3 is (i), wherein: X is O, S, NR w , or CH 2 ; wherein R w is hydrogen or alkyl; Y is C(O) or CH 2 ; R z and R y are independently, at each occurrence, hydrogen or C 1 -C 4 -alkyl; and m is 1, 2 or 3.