Patent ID: 8273861

Claim:
A method for labeling synthesis, comprising: (a) providing a UV reactor assembly comprising a high pressure reaction chamber with a gas inlet and a liquid inlet, a UV spot light source with a light guide, wherein the light guide is used to provide photo irradiation of a reaction mixture through a window in the reaction chamber, (b) preparing a carbanion solution by reacting a base with a carbanion precursor in a solution, (c) adding an alkyl or aryl iodide to the carbanion solution of step (b) to give a reagent volume to be labeled, (d) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber of the UV reactor assembly via the gas inlet, (e) introducing at high pressure said reagent volume into the reaction chamber via the liquid inlet, (f) turning on the UV spot light source and waiting for a predetermined time while the labeling synthesis occur, and (g) collecting the labeled ketone from the reaction chamber.