Patent ID: 8461340

Claim:
A method for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, the method comprising: conducting an isomerization of either a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, or a mixture of the trans- and cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivatives, in the presence of an aluminum compound represented by a formula Al(OR 1 ) 3 , wherein R 1 represents a hydrocarbon group in which a carbon atom having an oxygen atom bonded thereto is a secondary carbon atom; and a ketone compound represented by a formula R 2 —CO—R 3 , wherein R 2 and R 3 form a 5- to 10-membered ring together or R 2 and R 3 are different, and wherein R 2 and R 3 independently represent an alkyl group of 1 to 6 carbon atoms, a cycloalkyl group of 3 to 7 carbon atoms, an alkenyl group of 2 to 10 carbon atoms, a cycloalkenyl group of 4 to 10 carbon atoms, an aryl group of 6 to 10 carbon atoms, an aralkyl group of 7 to 10 carbon atoms, or a heterocyclic group formed of a 5- to 7-membered ring.