Patent ID: 8507522

Claim:
A compound of Formula (II), or a pharmaceutically acceptable salt thereof: E is absent or a cyclic group independently selected from aryl, heteroaryl, heterocyclic, C 3 -C 8 cycloalkyl, and C 3 -C 8 cycloalkenyl, each optionally substituted; T is absent or an optionally substituted aliphatic group: Ring G is a 5/6-membered fused heteroaryl other than benzimidazolyl, wherein the 6-membered ring of said 5/6-membered fused heteroaryl is attached to T, and wherein the 5-membered ring of said 5/6-membered fused heteroaryl is attached to group Q and contains one or more nitrogen atoms; and wherein said 5/6-membered fused heteroaryl is optionally substituted: Wherein Q in Formula II is represented by R 12 at each occurrence is independently selected from the group consisting of —O— and R 11 , —NR a R b , —R 13 , and —NR c R d ; R 11 at each occurrence is independently hydrogen or optionally substituted C 1 -C 8 alkyl; and R a and R b at each occurrence are each independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 8 alkyl, and optionally substituted C 2 -C 8 alkenyl; or R a and R b can be taken together with the nitrogen atom to which they are attached to form an optionally substituted heterocyclic or optionally substituted heteroaryl group; R 13 at each occurrence is independently selected from the group consisting of: hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 -alkynyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, heterocyclic, aryl, and heteroaryl, each optionally substituted; and R c and R d at each occurrence are each independently selected from the group consisting of hydrogen, —R 13 , —C(O)—R 13 , —C(O)—OR 13 , —S(O) 2 —R 13 , —C(O)N(R 13 ) 2 , and —S(O) 2 N(R 13 ) 2 ; m is 0, 1, or 2; n is 1, 2, 3, or 4; X at each occurrence is independently selected from O, S, S(O), SO 2 , and C(R 7 ) 2 ; provided that when m is 0, X is C(R 7 ) 2 ; and R 7 at each occurrence is independently selected from the group consisting of: hydrogen, halogen, cyano, —O—R 11 , —NR a R b , optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted —C 1 -C 4 alkyl; or two vicinal R 7 groups are taken together with the two adjacent atoms to which they are attached to form a fused, optionally substituted C 3 -C 8 cycloalkyl or optionally substituted heterocyclic ring: or alternatively two geminal R 7 groups are taken together with the carbon atom to which they are attached to form a spiro, optionally substituted C 3 -C 8 cycloalkyl or optionally substituted heterocyclic ring.