Patent ID: 8013015

Claim:
A pharmaceutical composition comprising a ghrelin O-acyltransferase (GOAT) inhibitor of the structure 1: wherein: R 1 , is selected from unsubstituted n-heptanyl, unsubstituted n-heptenyl, unsubstituted n-heptynyl and unsubstituted methyl-diethylene glycol (—CH 2 OCH 2 CH 2 OCH 2 CH 3 ); R 2 -R 5 are independently selected from hydrogen, optionally hetero-, optionally substituted alkyl, optionally hetero-, optionally substituted alkenyl, optionally hetero-, optionally substituted alkynyl, optionally hetero-, optionally substituted aryl, and an optionally substituted heteroatom; A is selected from NH, and N-alkyl; G is O; X is selected from hydroxyl, amino, alkylamino, and alkylthio; Y is C; and Z is selected from O, S, NH and N-alkyl, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, wherein said inhibitor inhibits said ghrelin O-acyltransferase (GOAT), and said composition is suitable for pharmaceutical use.