Patent ID: 8298791

Claim:
A method for producing a purine-derived substance comprising: A) culturing a Bacillus bacterium in a medium, and B) collecting said purine-derived substance, wherein said Bacillus bacterium is able to produce a purine-derived substance and has been modified to increase ribose-5-phosphate isomerase activity by increasing the copy number of a gene encoding the ribose-5-phosphate isomerase or modifying an expression control sequence of the gene encoding the ribose-5-phosphate isomerase, wherein said ribose-5-phosphate isomerase is selected from the group consisting of: (A) a protein comprising the amino acid sequence of SEQ ID NO: 50; and (B) a modified protein comprising the amino acid sequence of SEQ ID NO: 50 wherein one to 10 amino acids are substituted, deleted, inserted, or added, and said modified protein has ribose-5-phosphate isomerase activity.