Patent ID: 6998412

Claim:
A heterocyclic compound of the formula [1], or a pharmaceutically acceptable salt thereof: R 1 -Het-D-E [1] wherein: R 1 is aryl; said aryl being optionally substituted by the same or different one to three groups selected from alkyl, haloalkyl, trihaloalkyl, alkoxy, halogen and nitro; E is a group of the formula [3]: wherein Y is oxygen or sulfur; R 3 is hydrogen or alkyl; p is an integer of 0–2; Z is carboxy, alkoxycarbonyl, hydroxymethyl, carbamoyl, N-hydroxycarbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, cyano, 1H-5-tetrazolyl, 1-alkyl-5-tetrazolyl, or 2-alkyl-5-tetrazolyl; Het and D correspond to any one of the following cases (1) to (2) (1) Het is a thiazole which is optionally substituted by alkyl or trihaloalkyl; D is alkylene, alkenylene, or alkynylene; and (2) Het is an oxazole which is optionally substituted by alkyl or trihaloalkyl; and D is a group of the formula [2]: wherein m is an integer of 1–10 and n is an integer of 0–9, with the proviso that m+n is an integer of 1–10.