Patent ID: 7884113

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: R 1 is selected from the group consisting of hydrogen, alkyl, halo and CN; R 2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, acyl, halo, CF 3 , CN, nitro, phenyl, thienyl, pyridinyl, oxopyridinyl, oxopyrrolidinyl, oxopiperidinyl, imidazolyl, pyrazolyl and OR 11 , NR 12 R 12a , wherein phenyl, thienyl, pyridinyl, oxopyridinyl, oxopyrrolidinyl, oxopiperidinyl, imidazolyl and pyrazolyl may each be optionally substituted; R 3 is selected from the group consisting of hydrogen, alkyl, halo and CN; R 4 is selected from the group consisting of hydrogen, alkyl, halo and CN; R 5 is selected from the group consisting of cycloalkyl, phenyl, thienyl, pyrazinyl, pyridinyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyranyl, thiazolyl and isothiazolyl, wherein phenyl, thienyl, pyrazinyl, pyridinyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyranyl, thiazolyl and isothiazolyl may each optionally be substituted; R 6 and R 6a are each independently selected from the group consisting of hydrogen and alkyl; R 7 and R 7a are each independently selected from the group consisting of hydrogen and alkyl; R 8 is selected from the group consisting of hydrogen and alkyl; R 9 is selected from the group consisting of hydrogen and alkyl; R 10 is selected from the group consisting of optionally substituted phenyl; R 11 is phenyl; R 12 and R 12a are each independently selected from the group consisting of hydrogen and alkyl, or R 12 and R 12a taken together form morpholine, piperidine or pyrrolidine; X is selected from the group consisting of (CR 14 R 14a ) n , CO and S(O) 2 ; Y is S(O) 2 ; R 14 and R 14a are each independently selected from the group consisting of hydrogen and alkyl; n is an integer of 0, 1 or 2.