Patent ID: 7563914

Claim:
A process for preparing paclitaxel, comprising reacting 10-deacetyl baccatin in a “one-pot” reaction, successively: a) protecting the hydroxyl radical in the 7-position of the 10-DAB, with a silylated radical, then b) acetylating the hydroxyl radical in the 10-position, c) optionally, crystallizing a baccatin III compound obtained, followed by condensing (4S,5R)-3-N-benzoyl-2RS-methoxy-4-phenyl-1,3-oxazolidine-5-carboxylic acid of formula: by esterification in the 13-position of the 10-acetylated compound of baccatin III obtained above, of formula: in which Z is a silylated protective radical, so as to obtain a compound of formula: in which Z is a silylated protective radical, and then opening of the oxazolidine of the cyclic side chain and simultaneous deprotection of the hydroxyl radical in the 7-position, from its protective radical, and optional purification of the paclitaxel obtained.