Patent ID: 7141595

Claim:
A compound of Formula I, and pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof: wherein R 1 is selected from the group consisting of: R 2 is selected from the group consisting of H, —(CH 2 ) n R 8 and —(CH 2 ) m R 9 R 3 is selected from the group consisting of C 1-6 alkyl, SC 1-6 alkyl, thienyl and furanyl; R 4 is selected from the group consisting of H, C 1-6 alkyl, Ph, C(O)Ph and —C(O)C 1-6 alkyl; R 5 and R 6 are independently selected from the group consisting of H and C 1-6 alkyl or together R 5 and R 6 and the nitrogen to which they are attached form a 3 to 7-membered azacarbocylic ring wherein one of the carbon atoms in the ring may optionally be replaced with O, S, or NR 7 ; R 7 is selected from the group consisting of H, C 1-6 alkyl, Ph, Heteroaryl, CH 2 Ph, and CH 2 Heteroaryl, with Ph and Heteroaryl being optionally substituted with 1–3 groups independently selected from the group consisting of C 1-4 alkyl, halo, OH, OC 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl)(C 1-4 alkyl), nitro and cyano; R 8 is selected from the group consisting of H, OH, Ph, naphthyl and heteroaryl, with Ph, naphthyl and heteroaryl being optionally substituted with 1–3 groups independently selected from the group consisting of C 1-4 alkyl, halo, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl)(C 1-4 alkyl), nitro, cyano, OH and OC 1-4 alkyl; R 9 is C 3-7 cycloalkyl optionally substituted with 1–3 groups independently selected from the group consisting of C 1-4 alkyl, halo, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl)(C 1-4 alkyl), nitro, cyano, OH and OC 1-4 alkyl and one or two of the carbon atoms in C 3-7 cycloalkyl may optionally be replaced with O or S; n is 1–6; m is 0–6; o is 0–2; p is 1–2; and the group R 1 NH— is attached to the 5- or 6-position of the aminobenzothiazole ring, with the proviso that, when R 2 is H then R 4 is not C 1-6 alkyl.