Patent ID: 8492372

Claim:
A compound of Formula 1: any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein X is O, S, NH or CH 2 ; R 1 is selected from the group consisting of OSO 2 CF 3 , OSO 2 OH 3 , NHSO 2 CH 3 , NHSO 2 CF 3 , SOR 8 , SO 2 R 8 , SO 2 NH 2 , SO 2 NHCH 3 , SO 2 N(CH 3 ) 2 , COR 8 , CSR 8 , CN, OCF 3 , SCF 3 , OCHF 2 , SCHF 2 , CF 3 , F, Cl Br, I, NO 2 , SF 5 , SCN, OCN, OCOCF 3 , SCOCF 3 , OCOCH 3 , SCOCH 3 and CH(OH)CF 3 ; R 2 is selected from the group consisting of H, CN, F, Cl, Br, I and CH 3 ; R 3 is selected from the group consisting of C 1 -C 5 alkyl, allyl, CH 2 CH 2 OCH 3 , CH 2 CH 2 CH 2 F, CH 2 CH 2 CHF 2 , CH 2 CH 2 F, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, CH 2 CH 2 OH, CH 2 CH 2 CH 2 OH, CH 2 CH(OH)CH 3 , CH 2 CH 2 COCH 3 , C 3 -C 6 cycloalkyl, and R 4 is selected from the group consisting of H, C 1 -C 5 alkyl, allyl, CH 2 CH 2 OCH 3 , CH 2 CH 2 CH 2 F, CH 2 CH 2 CHF 2 , CH 2 CH 2 F, 3,3,3-trifluorpropyl, 4,4,4-trifluorobutyl, CH 2 CH 2 OH, CH 2 CH 2 CH 2 OH, CH 2 CH(OH)CH 3 , CH 2 CH 2 COCH 3 , or R 3 and R 4 together with the nitrogen atom to which they are attached form a four- to six-membered heterocyclic ring, which heterocyclic ring may optionally comprise as a ring member, one oxygen atom, and/or one additional nitrogen atom; and which heterocyclic ring may optionally be substituted with C 1 -C 5 alkyl; and R 5 , R 6 and R 7 are selected from the group consisting of H and CH 3 ; R 8 is selected from the group consisting of C 1 -C 3 alkyl, CF 3 , CHF 2 , CH 2 F and CN.