Patent ID: 7910756

Claim:
A process for the preparation of 2-substituted-derivatives of estrone and estradiol comprising i) the preparation of a compound of formula (II) by reacting a compound of formula (I) in one or more steps to a compound of formula II wherein R1 is a C1-C10 alkyl, alkenyl or aryl group; —Cl, —Br, —I, —F; —CN; —OH; or a —OR2, —O(CO)R2 or —R2—OH group, wherein R2 is an alkyl or alkylene group having 1-6 C atoms; and the bonding between atoms 9 and 10 is a single or a double bond ii) aromatization of the compound of formula II to a compound of formula III wherein R1 and R2 have the above defined meanings; and iii) optionally, reduction of the compound of formula III to a compound of formula IV wherein R1 and R2 have the above defined meanings.