Patent ID: 7462629

Claim:
A compound of Formula I: in which: n is 1, 2 or 3; A is chosen from —X 1 C(O)OR 6 , —X 1 OP(O)(OR 6 ) 2 , —X 1 P(O)(OR 6 ) 2 , —X 1 S(O) 2 OR 6 , —X 1 P(O)(R 6 )OR 6 and 1H-tetrazol-5-yl; wherein X 1 is chosen from a bond and C 1-3 alkylene; and each R 6 is independently chosen from hydrogen and C 1-6 alkyl; X is a bond or is chosen from C 1-4 alkyelene, —X 1 OX 2 —, —X 1 NR 7 X 2 —, —X 1 C(O)NR 7 X 2 —, —X 1 NR 7 C(O)X 2 —, —X 1 S(O)X 2 —, —X 1 S(O) 2 X 2 —, —X 1 SX 2 — and C 2-9 heteroarylene; wherein X 1 and X 2 are independently chosen from a bond and C 1-3 alkylene; R 7 is chosen from hydrogen and C 1-6 alkyl; and any heteroarylene of X is optionally substituted by a member of the group chosen from halo and C 1-6 alkyl; Y is C 6-10 aryl, wherein any aryl of Y can be optionally substituted with 1 to 3 radicals chosen from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl and halo-substituted C 1-6 alkoxy; R 1 is chosen from C 6-10 aryl and C 2-9 heteroaryl; wherein any aryl or heteroaryl of R 1 is substituted by a radical chosen from C 6-10 arylC 0-4 alkyl, C 2-9 heteroarylC 0-4 alkyl, C 3-8 cycloalkylC 0-4 alkyl, or C 3-8 heterocycloalkylC 0-4 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl group of R 1 can be optionally substituted by one to five radicals chosen from halo, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; and any alkyl group of R 1 can optionally have a methylene replaced by an atom or group chosen from —S—, —S(O)—, —S(O) 2 —, —NR 7 — and —O—; wherein R 7 is chosen from hydrogen or C 1-6 alkyl; R 2 , R 3 , R 4 and R 5 are independently chosen from hydrogen, C 1-6 alkyl, halo, hydroxy, C 1-6 alkoxy, halo-substituted C 1-6 alkyl and halo-substituted C 1-6 alkoxy; and the pharmaceutically acceptable salts, hydrates, solvates, isomers and prodrugs thereof.