Patent ID: 7504423

Claim:
An α-amino acid derivative of the formula (I) wherein R 1 is a hydrogen atom, a halogen atom, alkyl or alkoxy, R 2 is a hydrogen atom, a halogen atom, a hydroxyl group, alkyl or alkoxy, or R 1 and R 2 are joined to form oxo, hydroxyimino, alkoxyimino or alkylidene, X is CH—R 3 , Y is S, Z is a hydrogen atom or cyano, m and n are each 0, 1 or 2, wherein the sum of m and n is 2, when p is 1, R 3 is —NR 7 R 8 wherein R 7 and R 8 are optionally the same or different and each independently is a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, or are optionally bonded to each other to form heterocycle having at least one nitrogen atom, and optionally having other further hetero atom(s), wherein the heterocycle is optionally substituted or condensed with an aromatic ring optionally having substituent(s), —NR 9 COR 10 wherein R 9 and R 10 are optionally the same or different and each independently is a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl or heterocycle, —NR 11 CONR 12 R 13 wherein R 11 , R 12 and R 13 are optionally the same or different and each independently is a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, or R 12 and R 13 are optionally bonded to each other to form heterocycle having at least one nitrogen atom, and optionally having other further hetero atom(s), wherein the heterocycle is optionally substituted or condensed with an aromatic ring optionally having substituent(s), —NR 14 SO 2 R 15 wherein R 14 and R 15 are optionally the same or different and each independently is a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycle, —OR 16 or —OCOR 17 wherein R 16 and R 17 are each a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycle, and when p is 0, and R 3 is of formula (II) wherein is a single bond or a double bond, R 22 is aryl or heteroaryl, Q is 1 or 2, and A is a carbon atom or a nitrogen atom, provided that i) when A is a carbon atom, then A is optionally substituted by a hydroxyl group, carboxyl or alkoxycarbonyl, and ii) when A is a nitrogen atom, then is a single bond, wherein, of the above-mentioned groups, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl and heterocycle optionally have substituent(s), or a pharmaceutically acceptable salt thereof.