Patent ID: 8637497

Claim:
A compound having the formula: or an enantiomer, diastereomer, solvate, or pharmaceutically acceptable salt thereof, wherein: V is heterocyclyl substituted with 0-5 R e ; V′ is C 3-13 carbocyclyl substituted with 0-5 R e ; R e is H, T, C 1-8 alkylene-T, C 2-8 alkenylene-T, C 2-6 alkynylene-T, C(O)NR a ′(CR b ′R c ′) r -T, C(O)O(CR b ′R c ′) r -T, S(O) p (CR b ′R c ′) r -T, (CR b ′R c ′) r —O—(CR b ′R c ′) r -T, OH, Cl, F, Br, I, CN, NO 2 , NR I R II , COR III , COOR IV , OR IV , CONR I R II , NR I CONR I R II , OCONR I R II , NR I COR II , SO 2 NR I R II , NR I SO 2 R II , NR I SO 2 NR I R II , OSO 2 NR I R II , SO p R V , C 1-8 haloalkyl, C 3-13 carbocyclyl, heterocyclyl, carbocyclylalkyl, or heterocyclylalkyl, wherein each of said carbocyclyl, heterocyclyl, carbocyclylalkyl, and heterocylcylalkyl groups is optionally substituted by one or more C 1-8 alkyl, alkoxy, halo, haloalkyl, haloalkoxy, cyano, nitro, amino, alkylamino, dialkylamino, carboxy, carboxy alkyl ester, carboxy aryl ester, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, sulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylsulfonyl, arylsulfinyl, alkylsulfonyl or arylsulfonyl; T is H, C 1-10 alkyl substituted with 0 to 5 R b ′; C 2-10 alkenyl substituted with 0 to 5 R b ′, C 2-10 alkynyl substituted with 0 to 5 R b ′, C 3-13 carbocyclyl substituted with 0-3 R b ′, heterocyclyl substituted with 0-5 R b ′; R a ′, R b ′ and R c ′ are each, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, OH, Cl, F, Br, I, CN, NO 2 , NR I R II , COR III , COOR IV , OR IV , CONR I R II , R I NCONR I R II , OCONR I R II , R I NCOR II , SO 2 NR I R II , NR I SO 2 R II , NR I SO 2 NR I R II , OSO 2 NR I R II , SO p R V , C 1-8 haloalkyl, carbocyclyl, heterocyclyl, carbocyclylalkyl, heterocyclylalkyl, carbocyclyloxy or heterocarbocyclyloxy, wherein each of said carbocyclyl, heterocyclyl, carbocyclylalkyl, heterocyclylalkyl, carbocyclyloxy or heterocarbocyclyloxy groups is optionally substituted by one or more C 1-8 alkyl, alkoxy, halo, haloalkyl, haloalkoxy, cyano, nitro, amino, alkylamino, dialkylamino, carboxy, carboxy alkyl ester, carboxy aryl ester, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, sulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylsulfonyl, arylsulfinyl, alkylsulfonyl or arylsulfonyl; R I and R II are each, independently, H, C 1-6 alkyl or C 3-13 carbocyclyl; R III and R IV are each, independently, H, C 1-6 alkyl, haloalkyl, carbocyclyl, heterocyclyl, carbocyclylalkyl or heterocyclylalkyl, wherein said carbocyclyl, heterocyclyl, carbocyclylalkyl or heterocyclylalkyl are each optionally substituted by one or more halo, C 1-4 alkyl or C 1-4 alkoxy; R V is C 1-6 alkyl, haloalkyl, carbocyclyl or heterocyclyl; p=1 or 2; and r=0, 1, 2, 3, 4 or 5; with the proviso that the spiro ring is a stable chemical entity.