Patent ID: 7368428

Claim:
A method for restoring sensitivity to antitumorigenic effects of antiestrogen therapy, comprising contacting a breast tumor cell that is nonsensitive to the antitumorigenic effects of antiestrogen therapy with a PCDGF antagonist in an amount effective to restore sensitivity to antitumorigenic effects of antiestrogen therapy, wherein the PCDGF antagonist is an antibody or antibody fragment thereof produced from a hybridoma cell line selected from the group consisting of 6B3 hybridoma cell line (ATCC Accession Number PTA-5262), 6B2 hybridoma cell line (ATCC Accession Number PTA-5261), 6C12 hybridoma cell line (ATCC Accession Number PTA-5597), 5B4 hybridoma cell line (ATCC Accession Number PTA-5260), 5G6 hybridoma cell line (ATCC Accession Number PTA-5595), 4D1 hybridoma cell line (ATCC Accession Number PTA-5593), 3F8 hybridoma cell line (ATCC Accession Number PTA-5591), 3F5 hybridoma cell line (ATCC Accession Number PTA-5259), 3F4 hybridoma cell line (ATCC Accession Number PTA-5590), 3G2 (ATCC Accession Number PTA-5592), and 2A5 hybridoma cell line (ATCC Accession Number PTA-5589).