Patent ID: 8791158

Claim:
A method of treating a Meibomian gland dysfunction in the margins of an eye of a subject, comprising administering to the subject in need thereof an effective amount of a compound of formula I: wherein X is O; G is O; Z is NO 2 or CN; Y is CF 3 ; Q is CN; T is OH, OR or NHCOR; R is alkyl, aryl, alkenyl, halogen or OH; R 1 is CH 3 , CF 3 , CH 2 F, CHF 2 , CH 2 CH 3 or CF 2 CF 3 and n is 0 or 1; or its isomer, pharmaceutically acceptable salt, pharmaceutical product, N-oxide, hydrate, or any combination thereof; wherein the treating results in normalization of abnormal Meibomian gland secretions with an improvement in tear lipid composition, an increase in tear fatty acid content and an increase in the palmitate:stearate ratio of the abnormal Meibomian gland secretions in the eye of the subject having Meibomian gland dysfunction.