Patent ID: 7091201

Claim:
A compound of the formula I wherein R 1 and R 2 represent aryl or heteroaryl; R 3 represents phenyl; mono-, di- or tri-substituted phenyl substituted with substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, phenyl, lower alkoxy, amino, lower alkylamino, amino-lower alkyl, trifluoromethyl, trifluoromethoxy, halogen, lower alkylthio, hydroxy, hydroxy-lower alkyl, cyano, carboxyl, lower alkanoyl and formyl; benzofuranyl; or heteroaryl; R 4 represents hydrogen; halogen; trifluoromethyl; lower alkyl; lower alkyl-amino; lower alkoxy; lower alkyl-sulfono; lower alkyl-sulfinyl; lower alkylthio; lower alkylthio-lower alkyl; hydroxy-lower alkyl; lower alkyl-oxy-lower alkyl; hydroxy-lower alkyl-oxy-lower alkyl; hydroxy-lower alkyl-amino; lower alkyl-amino-lower alkyl; amino; di-lower alkyl-amino; [N-(hydroxy-lower alkyl)-N-(lower alkyl)]-amino; aryl; aryl-amino; aryl-lower alkyl-amino; aryl-thio; aryl-lower alkyl-thio; aryloxy; aryl-lower alkyl-oxy; aryl-lower alkyl; aryl-sulfinyl; heteroaryl; heteroaryl-oxy; heteroaryl- lower alkyl-oxy; heteroaryl-amino; heteroaryl-lower alkyl-amino; heteroaryl-thio; heteroaryl-lower alkyl-thio; heteroaryl-lower alkyl; heteroaryl-sulfinyl; heterocyclyl; heterocyclyl-lower alkyl-oxy; heterocyclyl-oxy; heterocyclyl-amino; heterocyclyl-lower alkyl-amino; heterocyclyl-thio; heterocyclyl-lower alkyl-thio; heterocyclyl-lower alkyl; heterocyclyl-sulfinyl; cycloalkyl; cycloalkyl-oxy; cycloalkyl-lower alkyl-oxy; cycloalkyl-amino; cycloalkyl-lower alkyl-amino; cycloalkyl-thio; cycloalkyl-lower alkyl-thio; cycloalkyl-lower alkyl; or cycloalkyl-sulfinyl; X represents oxygen; sulfur; NH; CH 2 or a bond; Y represents oxygen; sulfur or —NH—; Z represents oxygen; sulfur, —NH— or a bond; Q represents —(CH 2 ) k —; —(CH 2 ) m —C≡C—(CH 2 ) p —, in case p represents 0 (zero), Z represents a bond; or —CH 2 -cyclopropylen-CH 2 —; k represents the numbers 2, 3, 4, 5, or 6; m represents the numbers 1, 2, or 3; p represents the numbers 0, 1, 2 or 3; n represents the numbers 1, 2, or 3; or pure diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates, the meso-forms or pharmaceutically acceptable salts thereof.