Patent ID: 8487116

Claim:
A process for preparing a compound having structural formula (VIII), wherein, R 1 is hydrogen or alkyl and R 9 , R 10 , R 11 , and R 12 are each individually selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, aryl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, heteroaryl, heterocycle, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, (CF 3 ) 2 (HO)C—, R B (SO) 2 R A N—, R A O(SO) 2 —, R B O(SO) 2 —, Z A Z B N—, (Z A Z B N)alkyl, (Z A Z B N)carbonyl, (Z A Z B N)carbonylalkyl, and (Z A Z B N)sulfonyl, wherein Z A and Z B are each independently hydrogen, alkyl, alkylcarbonyl, formyl, aryl, or arylalkyl, provided that at least one of R 9 , R 10 , R 11 , or R 12 is other than hydrogen, or R 10 and R 11 taken together with the atoms to which they are attached form a cycloalkyl, cycloalkenyl or heterocycle ring; comprising, the steps of: (a) reacting a compound of formula (VI) with a compound of formula (VII) to provide a compound of formula (VIIIa) and (b) treating a compound of formula (VIIIa) with sodium hydroxide in methanol to provide the compound of formula (VIII)