Patent ID: 7842309

Claim:
An opioid antagonist composition having a structure comprising an inert core, a first layer, a second layer, and a third layer, the first layer being between the inert core and under the second layer, the second layer being between the first layer and the third layer, wherein the opioid antagonist is in the first layer and is sequestered by (i) a first hydrophobic material and additional excipients in the second layer and (ii) a second hydrophobic material and additional excipients in the third layer, such that the amount of the antagonist released from the opioid antagonist composition at 2 hours is undetectable by High Performance Liquid Chromatography, based on the in-vitro dissolution of the intact opioid antagonist composition, and such that, upon inclusion into a solid oral dosage form containing an opioid agonist, an amount of the opioid antagonist released from the solid oral dosage form which has been orally administered intact is insufficient to produce an antagonistic effect of the opioid antagonist in a human patient, and an amount of the opioid antagonist released from the solid oral dosage which has been tampered with and administered orally, intranasally, parenterally or sublingually will substantially block an effect of the opioid agonist, the second or the third layer is insoluble in a gastrointestinal system of a human, and the opioid antagonist composition is free from an opioid agonist.