Patent ID: RE43029

Claim:
A process for the synthesis of a creatine orotic acid, thioorotic acid, and dihydroorotic heterocyclic acid salt comprising the steps of: a) mixing creatine with a water appetent organic alcohol solvents, other water appetent organic solvents, solvent or water at a temperature of 1 to 100 degree Celsius, b) reacting the product mixture of step a) with orotic acid, thioorotic acid, or dihydroorotic acid at a temperature of 1 to 100 degree Celsius to produce a residue including the creatine heterocyclic acid salt ; C) filtering to remove the solvent and c) washing the residue with a water appetent organic alcohol solvents, other water appetent organic solvents, solvent or water ; and for the recovery of d) recovering the creatine heterocyclic acid salt from the residue, wherein the creatine heterocyclic acid salt is a mono, di, or tricreatine orotic acid, thioorotic acid, and or dihydroorotic acid salt.