Patent ID: 7429578

Claim:
A method of potentiating cytotoxicity of a DNA-damaging cytotoxic agent or ionizing radiation, comprising contacting cells with an effective amount of a compound of formula (I): wherein: R 1 is: H; halogen; cyano; an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group; or —C(O)—R 10 , where R 10 is: H; an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group; or OR 100 or NR 100 R 110 , where R 100 and R 110 are each independently H or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group R 2 is H or alkyl; R 3 is H or alkyl; R 4 is H, halogen or alkyl; X is O or S; Y is (CR 5 R 6 )(CR 7 R 8 ) n or N═C(R 5 ), where: n is 0 or 1; R 5 and R 6 are each independently H or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group; and R 7 and R 8 are each independently H or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group; wherein said optional substitutions are selected from the group consisting of hydroxy, F, Cl, I, Br, oxo, alkyl, acyl, sulfonyl, mercapto, nitro, alkylthio, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, carboxy, primary amino, secondary amino, tertiary amino, carbamoyl, aryloxy, heteroaryloxy, arylthio, and heteroarylthio; or a pharmaceutically acceptable salt thereof, in combination with the DNA-damaging cytotoxic agent or ionizing radiation.