Patent ID: 7862995

Claim:
A method of predicting whether a subject will respond to treatment with a dual tyrosine kinase inhibitor, the method comprising: (a.) analyzing a sample obtained from the subject to determine expression levels for a panel of targeted therapy markers, wherein the panel comprises neu differentiation factor (NDF), P70 S6 kinase protein (P-S6), and insulin-like growth factor-1 receptor (IGF-1R); and (b.) predicting that the subject will be responsive to treatment with the dual tyrosine kinase inhibitor where the sample is NDF positive, P-S6 positive and IGF-1R negative; or predicting that the subject will be non-responsive to treatment with the dual tyrosine kinase inhibitor where the sample is NDF negative, P-S6 negative and IGF-1R positive or NDF negative, P-S6 positive and IGF-1R positive.