Patent ID: 8722048

Claim:
An isolated T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID NO: 1) when presented by a major histocompatibility complex (MHC) molecule, the TCR comprising an α chain and a β chain, wherein the α chain comprises three complementarity determining regions (CDRs) having the following amino acid sequences: (SEQ ID NO: 4) CDR1α - SSNFYA, (SEQ ID NO: 5) CDR2α - MTLNGD, and (SEQ ID NO: 2) CDR3α - ARNTGNQFYFGTGTSLTVIPN, and wherein the β chain comprises three complementarity determining regions (CDRs) having the following amino acid sequences: (SEQ ID NO: 6) CDR1β - MNHEY, (SEQ ID NO: 7) CDR2β - SVGAGI, and (SEQ ID NO: 3) CDR3β - ASSFQTGASYGYTFGSGTRLTVL.