Patent ID: 7577470

Claim:
An analyte sensing device for sensing at least one analyte, the analyte sensing device comprising: an array of sealable wells; wherein each sealable well comprises an analyte sensor having a plurality of analyte sensor elements adapted to contact and sense analyte, the analyte sensor elements comprising: a base layer; at least three working electrodes disposed on the base layer; a glucose oxidase layer disposed upon the at least three working electrodes, wherein the least three working electrodes are coated with the glucose oxidase layer so as to allow the analyte sensing device to sense glucose; an analyte modulating layer disposed on the glucose oxidase layer, wherein the analyte modulating layer comprises a hydrogel composition that includes a compound selected for its ability to crosslink to a siloxane composition; an adhesion promoting layer disposed between the glucose oxidase layer and the analyte modulating layer that functions to promote adhesion between the glucose oxidase layer and the analyte modulating layer, wherein the adhesion promoting layer comprises a siloxane composition crosslinked to the compound in the analyte modulating layer and; at least one analyte sensor membrane disposed upon at least one sealable well in a manner that reversibly prevents an analyte from contacting the at least one of the plurality of analyte sensors, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and at least one structure operatively coupled to the analyte sensing device for relaying information away from the analyte sensing device.