Patent ID: 8071779

Claim:
A compound of Formula II: wherein: Q is (CR 4 R 5 ) n3; n 1 is 1; n 2 is 1; n 3 is 1-3; R 2 is isoquinoline-5-yl: Ar is a monocyclic aryl or bicyclic aryl; X is from 1 to 3 substituents on Ar, and each is independently selected from the group consisting of OR 8 , NR 8 R 9 , SR 8 , SOR 8 , SO 2 R 8 , SO 2 NR 8 R 9 , NR 8 SO 2 R 9 , CONR 8 R 9 , NR 8 C(â•O)R 9 , NR 8 C(â•O)OR 9 , OC(â•O)NR 8 R 9 , and NR 8 C(â•O)NR 9 R 10 ; R 3 is H; R 4 is H; R 5 is H or alkyl; R 8 is H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, or heterocycle; optionally substituted by one or more halogen or heteroatom-containing substituents selected from the group consisting of OR 11 , NR 11 R 12 , NO 2 , SR 11 , SOR 11 , SO 2 R 11 , SO 2 NR 11 R 12 , NR 11 SO 2 R 12 , OCF 3 , CONR 11 R 12 , NR 11 C(â•O)R 12 , NR 11 C(â•O)OR 12 , OC(â•O)NR 11 R 12 , and NR 11 C(â•O)NR 12 R 13 ; R 9 and R 10 are independently H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, or heterocycle; optionally substituted by one or more halogen or heteroatom-containing substituents selected from the group consisting of OR 14 , NR 14 R 15 , NO 2 , SR 14 , SOR 14 , SO 2 R 14 , SO 2 NR 14 R 15 , NR 14 SO 2 R 15 , OCF 3 , CONR 14 R 15 , NR 14 C(â•O)R 15 , NR 14 C(â•O)OR 15 , OC(â•O)NR 14 R 15 , and NR 14 C(â•O)NR 15 R 16 ; R 11 -R 17 are independently H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, or heterocycle; with the proviso that if X is acyclic and is connected to Ar by an oxygen or nitrogen atom, then X contains at least one additional oxygen, nitrogen or sulfur atom.