Patent ID: 6969726

Claim:
A compound having the formula: or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein: A is phenyl; B is phenyl; Hetâ€”CH 2 â€”R 3 is M is a 5-membered unsaturated heterocycle containing one or more nitrogen heteroatoms optionally substituted with one or more R 5 groups, wherein the heterocycle contains only nitrogen heteroatoms; Mâ€”L is Mâ€”L 1 â€”Xâ€”L 2 , wherein X, at each occurrence, independently is selected from the group consisting of: a)â€”NR 4 â€”, and b) â€”SO 2 NR 4 L 1 is selected from the group consisting of: a) C 1-6 alkyl, b) C 2-6 alkenyl, and c) C 2-6 alkynyl, wherein any of a)-c) optionally is substituted with one or more R 5 groups; and L 2 is selected from the group consisting of: a) C 1-6 alkyl, b) C 2-6 alkenyl, and c) C 2-6 alkynyl, wherein any of a)-c) optionally is substituted with one or more R 5 groups; R 1 , at each occurrence, independently is selected from the group consisting of: a) F, b) Cl, c) Br, and d) ; R 2 , at each occurrence, independently is selected from the group consisting of: a) F, b) Cl, c) Br, and d) ; R 3 is â€”NR 4 C(O)R 4 ; R 4 , at each occurrence, independently is selected from the group consisting of: a) H, and b) C 1-6 alkyl; R 5 , at each occurrence, is independently selected from the group consisting of: a) F, b) Cl, c) Br, d) I, e) â•O, f) â•S, g) â€”CF 3 , h) â€”CN, i) â€”NO 2 , j) â€”NR 6 R 6 , k) â€”C(O)OR 6 , l) â€”C(O)NR 6 R 6 , m) â€”S(O) p R 6 , and n) R 6 ; R 6 , at each occurrence, independently is selected from the group consisting of: a) H, b) C 1-6 alkyl c) C 2-6 alkenyl, and d) C 2-6 alkynyl, wherein any of b)-d) optionally is substituted with one or more R 7 groups; R 7 , at each occurrence, independently is selected from the group consisting of: a) F, b) Cl, c) Br, d) I, e) â•NR 8 , f) â€”CF 3 , g) â€”OR 8 , h) â€”CN, i) â€”NO 2 , j) â€”NR 8 R 8 , k) â€”C(O)R 8 , and l) â€”C(O)OR 8 ; R 8 , at each occurrence, independently is selected from the group consisting of: a) H, b) C 1-6 alkyl, c) C 2-6 alkenyl, and d) C 2-6 alkynyl, wherein any of b)-d) optionally is substituted with one or more moieties selected from the group consisting of F, Cl, Br, I, â€”CF 3 , and â€”OH; m is 0, 1, 2, 3, or 4; n is 0, 1, 2, 3, or 4; and p, at each occurrence, independently is 0, 1, or 2.