Patent ID: 7704543

Claim:
A method for modifying an amino-terminated surface of a solid support with carboxy groups comprising the steps of: a) providing an amino-terminated surface; and b) contacting the surface with a compound of the general formula (I): wherein at least three of R 1 to R 6 are, independent from each other, selected from —(CH 2 ) n —(C═O)—X—Y—Z, and the remaining R groups are H; or R 1 and R 6 form a ring; X is a group selected from C 1 -C 10 alkyl, C 1 -C 10 alkenyl, a C 3 -C 8 cycloalkyl, aryl, heteroaryl, or a polyethylene glycol chain of the general form (CH 2 —CH 2 —O) m , wherein m is an integer from 1 to 450, or X is a bond; Y is a carbonyl group, or a bond; Z is OH or an electron withdrawing group; and n is an integer from 0 to 10, under conditions allowing the formation of an amide bond between a carbon of a carboxy group of the compound of the general formula (I) and a nitrogen of the amino group of the solid surface.