Patent ID: 7678249

Claim:
A pharmacologic measurement instrument for detecting an electric signal caused by a pharmacologic action or electrophysiologic action of a biologic specimen, said pharmacologic measurement instrument comprising: an electrically conductive box provided with an opening section; and a well vessel disposed in said opening section of said electrically conductive box, wherein said well vessel comprises: a base substrate having a top surface and a plurality of well recesses, said plurality of well recesses being configured to hold biologic specimens; a plurality of measurement electrodes provided on bottom surfaces or back surfaces of respective well recesses of said plurality of well recesses; and a plurality of reference electrodes electrically insulated from respective measurement electrodes of said plurality of measurement electrodes, said plurality of reference electrodes being electrically connected to said electrically conductive box, wherein said reference electrodes cover said top surface of said base substrate and extend into said plurality of well recesses such that an upper portion of each of said respective well recesses is covered and a lower portion of each of said respective well recesses is not covered.