Patent ID: 7504208

Claim:
A process for the production of an 18 F-labeled tracer which comprises treatment of a solid support-bound precursor of formula (I): wherein the TRACER is of formula (A): wherein Y − is an anion, preferably trifluoromethylsulphonate (triflate) anion; and R 1 is either (i) a group CH—NP 1A P 2A in which P 1A and P 2A are each independently hydrogen or a protecting group, or (ii) a carbonyl group; with 18 F to produce the labelled tracer of formula (II) wherein R 1 is as defined for the compound of formula (I): optionally followed by: (i) removal of excess 18 F − , by ion-exchange chromatography; and/or (ii) removal of any protecting groups; and/or (iii) removal of organic solvent; and/or (iv) formulation of the resultant compound of formula (II) as an aqueous solution.