Patent ID: 7544371

Claim:
A matrix controlled diffusion drug delivery system comprising a therapeutically effective amount of one or more pharmaceutically active agents entrapped in a polymerization product of a monomeric mixture comprising one or more silicone-containing monomers of the general formula: wherein x and y are independently integers from 0 to about 300; m and m′ are independently integers from 1 to about 6, R is independently a straight or branched, substituted or unsubstituted, C 1 -C 30 alkyl group, a C 1 -C 30 fluoroalkyl group, an ether or polyether containing group or a C 1 -C 30 alkylamide group, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are independently hydrogen, a straight or branched C 1 -C 30 alkyl group, a C 1 -C 30 fluoroalkyl group, a C 1 -C 20 ester group, an alkyl ether, cycloalkyl ether, cycloalkylalkyl ether, cycloalkenyl ether, aryl ether, arylalkyl ether or polyether containing group, an ureido group, an amide group, an amine group, a substituted or unsubstituted C 1 -C 30 alkoxy group, a substituted or unsubstituted C 3 -C 30 cycloalkyl group, a substituted or unsubstituted C 3 -C 30 cycloalkylalkyl group, a substituted or unsubstituted C 3 -C 30 cycloalkenyl group, a substituted or unsubstituted C 5 -C 30 aryl group, a substituted or unsubstituted C 5 -C 30 arylalkyl group, a substituted or unsubstituted C 5 -C 30 heteroaryl group, a substituted or unsubstituted C 3 -C 30 heterocyclic ring, a substituted or unsubstituted C 4 -C 30 heterocyclolalkyl group, a substituted or unsubstituted C 6 -C 30 heteroarylalkyl group, fluorine, a vinyl group, a C 5 -C 30 fluoroaryl group, or a hydroxyl group; X is independently a straight or branched C 1 -C 30 alkyl group, a C 1 -C 30 fluoroalkyl group, a substituted or unsubstituted C 5 -C 30 arylalkyl group, a substituted or unsubstituted C 1 -C 30 alkoxy group, an ether, polyether, sulfide, or amino containing group and Z and Z′ are independently a polymerizable ethylenically unsaturated organic radical, wherein the matrix controlled diffusion drug delivery system is sized and configured for back of the eye delivery.