Patent ID: 8524862

Claim:
A mutein of the C5a anaphylatoxin which is a C5a receptor antagonist and which comprises a Cys27Ala mutation at position 27 and a C-terminal amino acid sequence wherein the amino acid residue naturally occurring at position 69 is mutated wherein the numbering of the amino acid sequence refers to the amino acid position defined by SEQ ID NO 13; wherein the C-terminal amino acid sequence is selected from SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46, SEQ ID NO: 47, and SEQ ID NO: 48, wherein the C-terminal amino acid sequence begins at position 67 with reference to SEQ ID NO 13; and wherein the fusion proteins of the mutein of SEQ ID NO: 14 with Jun/Fos and/or with Jun/Fos and the minor coat protein of the filamentous M13 phage fused to the N-terminus of the mutein are excluded.