Patent ID: 8637681

Claim:
A pyrrolyl substituted dihydroindol-2-one derivative of formula I, a pharmaceutically acceptable salt thereof, a solvate of said derivative, or a solvate of said salt, wherein, R 1 is selected from the group consisting of hydrogen atom and C 1-4 alkyl; R 2 is selected from the group consisting of C 1-4 alkyl, C 1-4 alkyl substituted with one or more halogen or hydroxyl groups, allyl, propargyl, —(CH 2 ) m NR 11 R 12 ,—SO j R 11 , —(CH 2 ) m SO j (CH 2 ) n NR 11 R 12 , —CO(CH 2 ) k NR 11 R 12 , —SO j (CH 2 ) m CH═CH(CH 2 ) n NR 11 R 12 , and —CO(CH 2 ) m CH═CH(CH 2 ) n NR 11 R 12 ; wherein R 11 and R 12 are each independently selected from the group consisting of hydrogen atom, C 1-4 alkyl, cycloalkyl, and heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl can be substituted with one or more substituents selected from the group consisting of halogen, alkyl, hydroxy, amino, and alkoxy groups; or R 11 and R 12 together with the N atom to which they are attached may form a 4- to 8-membered heterocycle, the heterocycle may further comprise 0 to 2 heteroatoms wherein the heteroatom is N, S, or O and the heterocycle can be substituted at any other positions, except S or O atom, with one or more substituents selected from the group consisting of C 1-4 alkyl, hydroxy-substituted C 1-4 alkyl, and —(CH 2 ) m NR 11 R 12 ; and wherein m, n each independently can be an integer of 0 to 4, k is an integer of 1 to 4, and j is 1 or 2; R 3 , R 4 are each independently selected from the group consisting of hydrogen atom, halogen, and C 1-4 alkyl; and R 5 , R 6 , R 7 , R 8 are each independently selected from the group consisting of hydrogen atom, halogen, C 1-4 alkyl, C 1-4 alkyl substituted with one or more halogens, C 1-4 alkoxy, alkoxy substituted with one or more halogens, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, hydroxy, —NR 9 R 10 , —SOR 9 , —SO 2 R 9 , —NR 9 SO 2 R 10 , —SO 2 NR 9 R 10 , —COR 9 , —NR 9 COR 10 , —OCOR 9 , —CN, and —NO 2 , wherein the aryl, heteroaryl, and cycloalkyl groups may be further substituted at any positions with a substituent selected from the group consisting of alkyl, halogen, haloalkyl, alkoxy, and haloalkoxy; R 9 and R 10 are each independently selected from the group consisting of hydrogen atom, C 1-4 alkyl, and C 1-4 alkyl substituted with one or more substituents selected from the group consisting of halogen, cycloalkyl, aryl, and heteroaryl, wherein the cycloalkyl, aryl, or heteroaryl can be substituted with one or more substituent selected from the group consisting of halogen, alkyl, hydroxy, amino, haloalkyl, alkoxy, and haloalkoxy, and wherein halogen is independently fluorine, chlorine, or bromine.