Patent ID: 6967201

Claim:
The compounds of Formula I: where: A is a piperazine of formula: R is hydrogen, halo, trifluoromethyl or C 1 –C 6 alkyl; R 1 is hydrogen, halo, trifluoromethyl, phenyl, or C 1 –C 6 alkyl; R 2 , R 3 , and R 4 are independently hydrogen, halo, dihalomethyl, trifluoromethyl, 1,1-difluoroethy-1-yl, cyano, C 1 –C 4 alkoxy, C 1 –C 4 alkoxycarbonyl, C 1 –C 6 alkyl, C 1 –C 6 alkyl, —C(O)NHR 9 , or C 1 –C 6 alkyl substituted with a substituent selected from the group consisting of halo, C 1 –C 4 alkoxy and hydroxy; R 5 , R 6 , R 7 and R 8 are independently hydrogen, phenyl, benzyl, hydroxymethyl, halomethyl, dihalomethyl, trihalomethyl, or benzyloxymethyl; R 5′ is hydrogen or methyl, provided that R 5′ may be methyl only when R 5 is other than hydrogen; R 6′ is hydrogen or methyl, provided that R 6′ may be methyl only when R 6 is other than hydrogen; R 7′ is hydrogen or methyl, provided that R 7′ may be methyl only when R 7 is other than hydrogen; R 8′ is hydrogen or methyl, provided that R 8′ may be methyl only when R 8 is other than hydrogen; R 9 is C 1 –C 8 alkyl where the alkyl chain is optionally substituted with a substituent selected from the group consisting of phenyl and pyridyl; or pharmaceutically acceptable acid addition salts thereof subject to the following provisos: a) when R 2 , R 3 , and R 4 are all selected from the group consisting of hydrogen, trifluoromethyl, cyano, C 1 –C 4 alkoxy, or C 1 –C 4 alkyl, neither R 6 nor R 7 may be hydrogen unless: 1. R is halo; 2. R 1 is halo or phenyl; 3. R 5 or R 8 are other than hydrogen; b) at least one of R 5 , R 6 , R 7 , or R 8 must be other than hydrogen; c) when R 1 is bromo or R is methyl, at least one of R 2 , R 3 , and R 4 must be other than hydrogen; and d) no more than two of R 5 , R 6 , R 7 , and R 8 may be other than hydrogen.