Patent ID: 8324284

Claim:
A method for inhibiting cancer cell migration in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having one of the following structures: or pharmaceutically acceptable salt thereof; wherein R 1 and R 2 are hydrogen or lower alkyl; R 3 , R 5 and R 6 are C 1-6 alkyl; the bond is a single bond or a double bond; R 4 is halogen or —OR 4A , wherein R 4A is hydrogen or an oxygen protecting group selected from a substituted methyl ether, a substituted ethyl ether, a substituted benzyl ether, a silyl ether, an ester, a carbonate, a cyclic acetal or a ketal; or R 4 , taken together with the carbon atom to which it is attached forms a moiety having the structure: , or R 4A is a C 1-6 alkyl group optionally substituted with one or more of C 1-20 aliphatic; C 1-20 heteroalkoxy,; F; Cl; Br; I; —OH; —NO 2 ; —CN; —CF 3 ; —CH 2 CF 3 ; —CHC1 2 ; —CH 2 OH; —CH 2 CH 2 OH; —CH 2 NH 2 ; —CH 2 SO 2 CH 3 ; —C(O)R x ; —CO 2 (R x ); —CON(R x ) 2 ; —OC(O)R x ; —OCO 2 R x ; —OCON(R x ) 2 ; —N(R x ) 2 ; S(O) 2 R x ; or —NR x (CO)R x , wherein each occurrence of R x is independently C 1-20 aliphatic or heteroC 1-20 aliphatic; X 1 is O, NR X1 or CR X1 R X2 ; wherein R X1 and R X2 are independently hydrogen, halogen, or a substituted or unsubstituted C 1-20 alkyl, heteroC 1-20 alkyl, or a nitrogen protecting group selected from a carbamate, an amide, a cyclic imide derivative, an N-alkyl amine, an N-aryl amine, an imine derivative or an enamine derivative; Q is hydrogen; Y 2 is hydrogen, or a substituted or unsubstituted C 1-20 alkyl or heteroC 1-20 alkyl; W is O or NH; and R Y1 is hydrogen or a substituted or unsubstituted C 1-20 aliphatic or heteroC 1-20 aliphatic moiety.