Patent ID: 8513414

Claim:
A process for preparing a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is —H, —Cl or —F; R 2 is —H or —F; R 3 is —C 1-4 aliphatic optionally substituted with 1-5 occurrences of R 5 ; R 4 is —C 1-2 alkyl optionally substituted with 1-3 occurrences of R 5 ; or R 3 and R 4 are taken together to form a 3-7 membered carbocyclic or heterocyclic saturated ring optionally substituted with 1-5 occurrences of R 5 ; each R 5 is independently selected from halogen, —OCH 3 , —OH, —NO 2 , —NH 2 , —SH, —SCH 3 , —NHCH 3 , —CN, or unsubstituted —C 1-2 aliphatic, or two R 5 groups, together with the carbon to which they are attached, form a cyclopropyl ring; R 6 is —H or unsubstituted —C 1-2 alkyl; and R 7 is a —CH 2 CR 3 or —(CH 2 ) 2 CR 3 wherein each R is independently —H or —F; comprising the step of: i) reacting a compound of Formula 1 with a hydrochloride salt of a compound Formula 2 in the presence of water, an organic solvent, a base, and a transition metal catalyst to generate a compound of Formula I.