Patent ID: 8231897

Claim:
A dosage form for oral administration, consisting of: I) a compressed homogeneous mixture comprising: a pharmacologically-active substance; one or more pharmaceutical excipients selected from the group consisting of a viscosity enhancers, enteric polymers, diluents, anti-adherents, glidants, binders, solubilizer, stabilizers, compaction enhancers, channeling agents, wetting agents, buffering agents, flavorants, adsorbents, sweetening agents, plasticizers, fillers, surfactants, colorants, and lubricants; and a hydrostatic couple consisting of: a) at least one crosslinked hydrodynamic fluid-imbibing polymer selected from the group consisting of: i) an acrylic-acid polymer cross-linked with allylsucrose or allylpentaerythritol; ii) one or more starch derivatives cross-linked by epichlorhydrin, phosphorous oxychloride (POCl 3 ), or sodium trimetaphosphate; iii) a crosslinked polyglucan; iv) a crosslinked polyethylenimine; v) a crosslinked polyallylamine, and vi) combinations thereof; and b) at least one crosslinked hydrostatic pressure-modulating agent selected from the group consisting of: i) a homopolymer of cross-linked N-vinyl-2-pyrollidone; ii) a rapidly expanding cross-linked cellulose derivative; and iii) combinations thereof; and II) an outer coating.