Patent ID: 8349824

Claim:
A compound of formula (I) wherein R 1 is halogen, lower-alkyl, lower-haloalkyl, lower-hydroxyalkyl, lower-alkoxy, lower-alkoxy-lower-alkyl, —C(O)—NR 9 R 10 , aryl, heteroaryl or NR 7 R 8 , wherein said aryl and said heteroaryl are each optionally substituted by 1 to 3 substituents independently selected from the group consisting of hydroxyl, halogen, lower-alkyl, lower-alkoxy, lower-alkoxy-lower-alkyl, lower-haloalkyl and lower-haloalkoxy; R 2 is hydrogen, halogen, lower-alkyl, lower-haloalkyl, lower-hydroxyalkyl, lower-alkoxy or lower-alkoxy-lower-alkyl; R 3 is hydrogen, lower-alkyl, lower-haloalkyl, lower-hydroxyalkyl, lower-alkoxy or lower-alkoxy-lower-alkyl; R 4 is hydroxyl, lower-alkoxy or NR 5 R 6 ; R 5 and R 6 are each independently hydrogen, lower-alkyl, lower-haloalkyl, lower-hydroxyalkyl, lower-alkoxy-lower-alkyl, cycloalkyl or heterocyclyl, or R 5 and/or R 6 are lower-alkyl substituted by a substituent selected from the group consisting of heteroaryl, lower-alkyl-heteroaryl and lower-alkoxy-C(O)—, or R 5 and R 6 , together with the nitrogen atom to which they are attached, form a heterocyclyl, bicyclo-heterocyclyl or spiro-heterocyclyl, wherein said heterocyclyl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of hydroxyl, halogen, lower-alkyl, lower-alkoxy, lower-alkoxy-lower-alkyl, lower-haloalkyl and oxo; R 7 and R 8 are each independently hydrogen, lower-alkyl, lower-haloalkyl, lower-hydroxyalkyl, lower-alkoxy-lower-alkyl or cycloalkyl, or R 7 and R 8 , together with the nitrogen atom to which they are attached, form a heterocyclyl optionally substituted by a substituent selected from the group consisting of hydroxyl, halogen and oxo; and R 9 and R 10 are each independently hydrogen, lower-alkyl, lower-haloalkyl, lower-hydroxyalkyl or lower-alkoxy-lower-alkyl, or a pharmaceutically acceptable salt thereof.