Patent ID: 7476751

Claim:
A process for the synthesis of a compound of formula (I) wherein 7-methoxy-1-tetralone of formula (IV): is reacted with cyanoacetic acid of formula (V): wherein the water formed during the reaction is removed, in the presence of a catalytic amount of a compound of formula (VI): wherein R and R′, which may be the same or different, each represents linear or branched (C 3 -C 10 )alkyl, unsubstituted or substituted aryl, or unsubstituted or substituted linear or branched aryl (C 1 -C 6 )alkyl, to yield, after filtration and washing with a basic solution, (7-methoxy-3,4-dihydro-1-naphthalenyl)acetonitrile of formula (VII): wherein the compound of formula (VII) thus obtained is reacted with a hydrogenation catalyst in the presence of an allyl compound, to yield the compound of formula (I) after filtration and removal of the solvent by evaporation, wherein the compound of formula (I) is isolated in the form of a solid after recrystallisation, it being understood that: aryl may be phenyl, naphthyl or biphenyl, the term substituted associated with the terms aryl and arylalkyl denotes that the aromatic moiety of those groups may be substituted by one or more, identical or different, groups selected from linear or branched (C 1 -C 6 )alkyl, hydroxy and linear or branched (C 1 -C 6 )alkoxy, allyl compound may be any molecule containing from 3 to 10 carbon atoms, which may additionally contain 1 to 5 oxygen atoms, and containing at least one —CH 2 —CH═CH 2 group.