Patent ID: 8088778

Claim:
A compound of Formula IV: or a pharmaceutically acceptable salt thereof, wherein t is 1 or 2; R 1 , R 2 , R 3 , and R 4 are, independently, H, F, Cl, Br, CF 3 , CH 3 , OH, OCH 3 , CH 2 OCH 3 , or CH 2 OCH 2 CH 3 ; R 5 and R 6 are, independently, H, CH 3 , CH 2 CH 3 , or R 5 and R 6 , together with the carbon to which they are attached, are connected to form a spiro ring of 3 to 7 carbon atoms; and Z is selected from CO 2 H, CONHS(O) 2 -alkyl, CONHS(O) 2 -cycloalkyl, CONHS(O) 2 -heteroalkyl, and tetrazole; in which alkyl is methyl, C 2 , C 3 , C 4 , C 5 or C 6 straight chain alkyl or C 3 , C 4 , C 5 or C 6 branched alkyl; cycloalkyl is C 3 , C 4 , C 5 , C 6 , C 7 , or C 8 cycloalkyl; heteroalkyl is an alkyl or cycloalkyl group which contains at least one heteroatom selected from nitrogen, oxygen, sulfur and phosporus; and tetrazole is provided that the compound is not 3-[4-(1,2-benzisoxazol-3-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid or a pharmaceutically acceptable salt thereof.