Patent ID: 8106045

Claim:
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof; wherein each symbol is as defined below; X represents CH or N; R 1 represents a C 1 -C 12 alkyl; R 2 represents a hydrogen atom; R represents a formula (1); in the formula (1), R 3 represents a hydrogen atom, or a C 1 -C 6 alkyl which may be substituted by hydroxyl or a C 1 -C 6 alkoxy; R 4 represents a formula (3) wherein m represents 0 or an integer of 1 to 4, Z 1 represents a carbonyl group, R20 and R21 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl; R 7 represents a C 1 -C 6 alkyl which may be substituted by hydroxyl or halogen atom, a C 3 -C 7 cycloalkyl which may be substituted by C 1 -C 6 alkyl, hydroxyl or C 1 -C 6 alkoxy, a C 6 -C 10 aryl which may be substituted by N,N-di-C 1 -C 6 alkylamino, a heterocyclic group which may be substituted by phenyl or C 1 -C 6 alkyl, or a C 1 -C 6 alkoxy which may be substituted by phenyl.