Patent ID: 7579435

Claim:
A somatostatin-dopamine chimeric compound of the formula (I), wherein: X is H, Cl, Br, I, F, —CN, or C 1-5 alkyl; R1 is H, C 1-4 alkyl, allyl, alkenyl or —CN; R2 and R3, each are, independently H or absent, provided that R2 and R3 are not both absent; R4 is H or —CH 3 ; Y is —O—, —C(O)—, —S—, —S—(CH 2 )s-C(O)—, —S(O)—, —S(O) 2 —, —SC(O)—, —OC(O)—, —N(R5)-C(O)—, or —N(R6)-; R5, R6, R7 and R8 each is, independently, H or C 1-5 aikyl; m is 0 or 1; n is 0-10; L is —(CH 2 )p-C(O)—, when Y is —S—, —S(O)—, —S(O) 2 —, —O— or —N(R6)-; L is —C(O)—(CR7R8)q-C(O)—, when Y is —N(R6)-, —O—, or —S—; L is -(Doc)t-, when Y is —C(O)—, SC(O)—, —OC(O)—, —S—(CH 2 )s-C(O)—, or —N(R5)-C(O)—; p is 1-10; q is 2-4; s is 1-10; t is 1-10; wherein said dopamine moiety binds to a dopamine D2 receptor; and Z is an SSTR-2 peptide somatostatin analog selected from the group consisting of; D-Nal-cyclo[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH 2 ; D-Phe-cyclo[Cys-Tyr-D-Trp-Lys-Thr-Cys]-Nal-NH 2 ; D-Phe-cyclo[Cys-Tyr-D-Trp-Lys-Abu-Cys]-Thr-NH 2 ; D-Phe-cyclo[Cys-(3-Bromo-Tyr)-D-Trp-Lys-Thr-Cys]-Thr-NH 2 ; D-Ser-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-NH 2 ; D-Ser-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol; D-Tyr-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-NH 2 ; D-Tyr-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol; D-Phe-cyclo[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol; D-Phe-cyclo[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH 2 ; D-Ser-cyclo[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH 2 ; D-Tyr-cyclo[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH 2 ; D-Phe-cyclo[D-Cys-Pal-D-Trp-Lys-D-Cys]-Thr-(Bzl)-Tyr-NH 2 ; cyclo[Cys-Phe-Phe-D-Trp-Lys-Thr-Phe-Cys]-NH 2 ; D-Tyr-cyclo[Cys-Phe-Phe-D-Trp-Lys-Thx-Phe-Cys]-NH 2 ; cyclo[Cys-Phe-Tyr-D-Trp-Lys-Thr-Phe-Cys]-NH 2 ; D-Tyr-cyclo[Cys-Phe-Tyr-D-Trp-Lys-Thr-Phe-Cys]-NH 2 ; Ser-cyclo[Cys-Phe-Phe-D-Trp-Lys-Thr-Phe-Cys]-NH 2 ; D-Phe-cyclo[Cys-Phe-D-Trp-Lys-Val-Cys]-Thr-NH 2 ; D-Tyr-cyclo[Cys-Phe-D-Trp-Lys-Val-Cys]-Thr-NH 2 ; D-Tyr-cyclo[Cys-Tyr-D-Trp-Lys-Abu-Cys]-Thr-NH 2 ; D-Phe-cyclo[Cys-(3-Iodo-Tyr)-D-Trp-Lys-Val-Cys]-Thr-NH 2 ; or a pharmaceutically acceptable salt thereof.