Patent ID: 7176229

Claim:
A method of treating a mammal for asthma, chronic bronchitis, allergic rhinitis, adult respiratory distress syndrome, chronic pulmonary inflammatory disease, chronic obstructive pulmonary disease, silicosis, or pulmonary sarcoidosis, said method comprising administering to said mammal a therapeutically effective amount of the compound having a formula wherein R 1 is selected from the group consisting of hydrogen, lower alkyl, bridged alkyl, aryl, cycloalkyl, a 4-, 5-, or 6-membered saturated heterocycle, heteroaryl, C 1-4 alkylenearyl, C 1-4 alkyleneOaryl, C 1-4 alkyleneheteroaryl, C 1-4 alkyleneHet, C 2-4 alkylenearylOaryl, C 1-4 alkylene bridged alkyl, C 1-4 alkylenecycloalkyl, substituted or unsubstituted propargyl, substituted or unsubstituted allyl, and halocycloalkyl; R 2 is selected from the group consisting of hydrogen, methyl, and halo-substituted methyl; R 3 is selected from the group consisting of C(═O)OR 7 , C(═O)R 7 , NHC(═O)OR 7 , C 1-3 alkyleneC(═O)OR 8 , C 1-3 alkyleneC(═O)R 8 , C(═NH)NR 8 R 9 , C(═O)NR 8 R 9 , C(═O)C(═O)NR 8 R 9 , C(═O)C(═O)OR 8 , C 1-4 alkyleneOR 8 , aryl, C 1-3 alkylenearyl, C 1-3 alkyleneheteroaryl, SO 2 heteroaryl, Het, and heteroaryl; R 4 is selected from the group consisting of hydrogen, lower alkyl, haloalkyl, cycloalkyl, and aryl; R 5 is selected from the group consisting of hydrogen, lower alkyl, alkynyl, haloalkyl, hydroxyalkyl, cycloalkyl, and aryl; R 6 is selected from the group consisting of hydrogen, lower alkyl, and C(═O)R 7 ; R 7 is selected from the group consisting of lower alkyl, branched or unbranched, C 1-4 alkylenearyl, cycloalkyl, Het, C 1-4 alkylenecycloalkyl, heteroaryl, and aryl, each optionally substituted with one or more of OC(═O)R 8 , C(═O)OR 8 , OR 8 , NR 8 R 9 , or SR 8 ; R 8 and R 9 , same or different, are selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryl, heteroaryl, C(═O)Oalkyl, C(═O)Oaryl, C(═O)alkyl, alkylSO 2 , haloalkylSO 2 , C(═O)C 1-3 alkylenearyl, C(═O)OC 1-4 alkylenearyl, C 1-4 alkylenearyl, and Het, or R 8 and R 9 together form a 4-membered to 7-membered ring; R 10 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, aryl, C(═O)alkyl, C(═O)cycloalkyl, C(═O)aryl, C(═O)Oalkyl, C(═O)Ocycloalkyl, C(═O)aryl, CH 2 OH, CH 2 Oalkyl, CHO, CN, NO 2 , and SO 2 R 11 ; R 11 is selected from the group consisting of alkyl, cycloalkyl, trifluoromethyl, aryl, aralkyl, and NR 8 R 9 ; or a salt thereof.