Patent ID: 8754190

Claim:
A compound of the formula wherein m is 0 or 1; wherein at least one, or both R 1 and R 2 is independently CN; NO 2 ; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted alkenyl; optionally substituted alkynyl; COR 3 or SOR 3 or SO 2 R 3 wherein R 3 is H or optionally substituted alkyl; aryl or arylalkyl, each optionally substituted; heteroaryl or heteroarylalkyl, each optionally substituted; or OR 9 or NR 9 2 wherein each R is independently H or optionally substituted alkyl, or both R 9 groups taken together with the nitrogen to which they are attached form a heterocyclic ring; SR 4 wherein R 4 is optionally substituted alkyl; aryl or arylalkyl, each optionally substituted; or heteroaryl or heteroarylalkyl, each optionally substituted; wherein R 1 and R 2 may be joined to form a 3-8 membered ring; and wherein one and only one of R 1 and R 2 may be H or alkyl, arylalkyl or heteroarylalkyl, each optionally substituted; each R 5 is independently H or is alkyl, alkenylalkyl, alkynylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, each optionally substituted; Z is a residue of a drug or prodrug coupled through O, S, or non-basic N or is a nucleofuge that mediates said coupling; B is alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, each optionally substituted; and wherein one of R 1 , R 2 , R 5 or B is coupled to a macromolecule or one of R 1 , R 2 or R 5 comprises a functional group for mediating said coupling.