Patent ID: 8329911

Claim:
A compound of formula I: where: a is 0 or 1; R 1 is halo; b is 0 or 1; R 2 is halo; A is selected from: where m is 0 or 1; s is 0, 1 or 2; t is 0, 1 or 2; R 4 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; and Ar 1 represents a phenylene group substituted with (R 5 ) q where q is 0 or an integer from 1 to 4 and each R 5 is independently selected from halo, hydroxy, (1-4C)alkyl and (1-4C)alkoxy; R 6 is selected from hydrogen and (1-4C)alkyl; X 1 is selected from (1-3C)alkylene and —SO 2 —; where the alkylene is optionally substituted with 1 or 2 substituents independently selected from (1-4C)alkyl and —NR Xa R Xb ; wherein R Xa and R Xb independently selected from hydrogen and (1-4C)alkyl; p is 0 or 1; R 7 is —OR 7a , where R 7a is (1-4C)alkyl or (3-6C)cycloalkyl; and R 8 is selected from (1-4C)alkyl, (1-4C)alkyleneNR 8a R 8b , and phenyl, where each of R 8a and R 8b is independently hydrogen or (1-4C)alkyl; or R 8 is taken together with R 7 to form a ring having 1 to 2 oxygen atoms, where said ring is unsubstituted or substituted by 1 or 2 (1-4C)alkyl substituents; wherein each alkyl and alkoxy group in R 7 , R 7a , R 8 , and R 8a-8b is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.