Patent ID: 7179805

Claim:
A compound having a structure according to Formula I wherein: n is an integer from 1 to 3; m is an integer from 1 to 3; z is an integer from 0 to 3; R is selected from hydrogen, hydroxy, and alkoxy; R 2 is hydrogen; R 3 and R 4 are independently selected from hydrogen, halogen, amino, hydroxy, alkoxy, alkylthio, alkyl, alkenyl and alkynyl; R 5 is selected from hydrogen, hydroxy, halogen, alkyl, aryl, alkoxy, and alkylthio; R 6 is independently selected from alkyl, hydroxy, alkoxy, alkylthio, alkenyl, alkynyl, aryl, alkoxyimino, and halogen; or R 5 and R 6 join to form a 4- to 7-membered carbocyclic ring wherein each carbon atom of the ring can be optionally substituted with R 12 , wherein R 12 is selected from the group consisting of halogen, amino, hydroxy, alkoxy, alkylthio, alkyl, alkenyl, alkynyl, oxo, alkoxyimino and hydroxyimino; E is selected from the group consisting of: wherein, q is an integer from 1 to 3; R 7 and R 8 are each independently selected from hydrogen and alkyl, or R 7 and R 8 join to form a 3 to 6 membered carbocyclic ring, or either of R 7 or R 8 can be joined independently to either of R 9 or R 10 to form a heterocyclic ring containing the nitrogen atom to which R 9 or R 10 are bonded,wherein R 9 and R 10 are each independently selected from hydrogen, alkyl, acyl, alkoxycarbonyl, or sulfonyl, or alternatively R 9 and R 10 join to form a heterocyclic ring containing the nitrogen atom to which they are bonded; wherein, q is as defined above; R 7 and R 8 are each independenly selected from hydrogen and alkyl, or R 7 and R 8 join to form a 3- to 6-membered carbocyclic ring, and R 9 is selected from hydrogen, alkyl, acyl, alkoxycarbonyl, or sulfonyl; and 3) alkenyl; A is selected from N and C (R 11 ), wherein R 11 is selected from hydrogen, alkyl, halogen, hydroxy, alkoxy, alkylthio, and cyano; X is selected from C and N, where if X is C, a is a double bond and b is a single bond, and if X is N, a is a single bond and b is a double bond; and Y is selected from N(R 1 ) and C(R 1 ), with the proviso that when Y is N(R 1 ), X is C and when Y is C(R 1 ), X is N, wherein R 1 is selected from C3 to C6 cycloalkyl, C4 to C6 heterocycloalkyl, alkyl, alkene, a 6-membered aryl and a 6-membered heteroaryl; provided that if A is C(R 11 ), X is C and Y is N(R 1 ), then R 11 and R 1 can join to form a 6-membered heterocyclic ring, or if A is C(R 11 ), X is C and Y is N(R 1 ), then R 2 and R 1 can join to form a monocyclic or bicyclic heterocyclic ring, or if A is C(R 11 ), X is C and Y is N(R 1 ), then R 2 and R can join to form a 5-membered heterocyclic ring,; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.