Patent ID: 8388972

Claim:
An isolated or purified antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRa), wherein said antibody or fragment thereof is a Fab fragment comprising a light chain and a heavy chain, the light chain having a variable region (V L ) and a constant region (C L ), the heavy chain having a variable region (V H ) and a first constant region (C H1 ), and wherein the variable region (V L ) comprises the following amino acid sequences: RASESVSFLGINLIH, (SEQ ID NO: 3) QASNKDT, (SEQ ID NO: 4) LQSKNFPPYT, (SEQ ID NO: 5) the constant region (C L ) is a kappa constant region, the variable region (V H ) has the amino acid sequence of SEQ ID NO: 2; and the first constant region (C H1 ) is an IgG heavy chain.