Patent ID: 7276286

Claim:
An article, comprising: a substrate having covalently bonded thereon a chemical chain, the chemical chain comprising a terminal group comprising the structure: wherein the terminal group is hydrophilic; E is selected from the group consisting of nitrogen, oxygen, phosphorus and sulfur; X is an organic substituent and m is an integer less than or equal to 3; Y is selected from the group consisting of amides, amide derivatives, amines, amine derivatives, cyclic ethers, sugar derivatives, amino acids, amino acid derivatives, and multiple nitriles and p is an integer greater than 0; X and Y are both free of a hydrogen-bond donor; R 1 is selected from the group consisting of hydrogen, a C 1 -C 6 alkyl and an aryl, and n is an integer less than or equal to 2; represents one or more single bonds, a double bond, or any combination thereof; q is an integer greater than 0; optionally R 1 can bond to X or Y to form a cyclic structure; the chemical chain further comprising a linker covalently bonded to the terminal group and to the substrate; and the article being resistant to the adsorption of proteins, cells or bacteria.