Patent ID: 8088762

Claim:
A compound of Formula (I), or a pharmaceutically acceptable salt thereof; wherein the compound of Formula (I) is: wherein: R m is a hydrogen or a lower alkyl group; R n is: s is an integer of 0 or 1; X is: (1) —Y—(CH 2 ) o —(W) q —(CH 2 ) o —V—(CR 4 R 4 ′) o -Q′—(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (2) —Y—(CR 4 R 4 ′) o -Q′—(CR 4 R 4 ′) o —V—(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (3) —Y—(CR 4 R 4 ′) p -T-(CR 4 R 4 ′) p -Q′-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (4) —Y—(CR 4 R 4 ′) o -Q′-(CR 4 R 4 ′) o -T-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (5) —Y—(CR 4 R 4 ′) q —V—(CR 4 R 4 ′) o -Q′-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (6) —Y—(CR 4 R 4 ′) o —V—(CR 4 R 4 ′) o -Q′-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (7) —Y—(CR 4 R 4 ′) q —C(Z)-Q′-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (8) —Y—(CR 4 R 4 ′) p -(T) o -Q′-(T) o —(CR 4 R 4 ′) q —(CH 2 )—ONO 2 ; (9) —Y—(CR 4 R 4 ′) q —C(Z)—(CR 4 R 4 ′) q —V—(CR 4 R 4 ′) o -Q′-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (10) —Y—(CR 4 R 4 ′) q —C(Z)—(CR 4 R 4 ′) q —(W) q —(CR 4 R 4 ′) o -Q′-(CR 4 R 4 ′) o —(CH 2 )—ONO 2 ; (11) —Y—(CR 4 R 4 ′) o —V—(CR 4 R 4 ′) o -Q-(CR 4 R 4 ′) o —ONO 2 ; R 4 and R 4 ′ at each occurrence are independently a hydrogen, lower alkyl group, —OH, —CH 2 OH, —ONO 2 , —NO 2 or —CH 2 ONO 2 ; or R 4 and R 4 ′ taken together with the carbon atom to which they are attached are a cycloalkyl group or a heterocyclic ring; V is —C(O)-T-, -T-C(O)—, -T-C(O)-T or T-C(O)—C(O)-T; W is a covalent bond or a carbonyl group; T at each occurrence is independently an oxygen, (S(O) o ) o or NR j ; R j is a hydrogen, an alkyl group, an aryl group, a heterocyclic ring, an alkylcarbonyl group, an alkylaryl group, an alkylsulfinyl group, an alkylsulfonyl group, an arylsulfinyl group, an arylsulfonyl group, a sulfonamido group, a N-alkylsulfonamido group, a N,N-diarylsulfonamido group, a N-arylsulfonamido group, a N-alkyl-N-arylsulfonamido group, a carboxamido group or a hydroxyl group; p at each occurrence is independently an integer from 1 to 6; q at each occurrence is independently an integer from 1 to 3; o at each occurrence is independently an integer from 0 to 2; Y is oxygen or sulfur (—S—); Q′ is a cycloalkyl group, a heterocyclic ring or an aryl group; Z is (═O), (═N—OR 5 ), (═N—NR 5 R′ 5 ) or (═CR 5 R′ 5 ); R 5 and R 5 ′ at each occurrence are independently a hydrogen, a hydroxyl group, an alkyl group, an aryl group, an alkylsulfonyl group, an arylsulfonyl group, a carboxylic ester, an alkylcarbonyl group, an arylcarbonyl group, a carboxamido group, an alkoxyalkyl group, an alkoxyaryl group, a cycloalkyl group or a heterocyclic ring.