Patent ID: 7910728

Claim:
A process for the manufacture of a macrocyclic compound of formula VII comprising the steps of: (a) contacting a diene of formula II wherein R 1 is an amino protecting group and X is a halogen atom, with a penta-coordinated ruthenium (II) carbene complex ring-closing catalyst to form a macrocyclic ester of formula I wherein R 1 is an amino protecting group, R 2 is C 1-4 -alkyl and X is halogen; b) hydrolyzing the macrocyclic ester of formula I in the presence of a base to form a macrocyclic acid of the formula XX wherein R 1 is an amino protecting group and X is halogen; c) coupling the macrocyclic acid of formula XX with cyclopropyl sulfonamide to form a macrocyclic sulfonamide of formula; and, d) treating the macrocyclic sulfonamide of formula XXI with a sodium base to form a macrocyclic compound of formula VII.