Patent ID: 8551478

Claim:
A method of alleviating a symptom of rheumatoid arthritis, the method comprising administering an anti-CD3 antibody to a subject in need thereof in an amount sufficient to alleviate the symptom of rheumatoid arthritis in the subject, wherein the anti-CD3 antibody has a heavy chain with three complementarity determining regions (CDRs), comprising a VH CDR1 comprising the amino acid sequence GYGMH (SEQ ID NO:27); a VH CDR2 comprising the amino acid sequence VIWYDGSKKYYVDSVKG (SEQ ID NO:28); and a VH CDR3 comprising the amino acid sequence QMGYWHFDL (SEQ ID NO:29); and a light chain with three CDRs, comprising a VL CDR1 comprising the amino acid sequence RASQSVSSYLA (SEQ ID NO:30); a VL CDR2 comprising the amino acid sequence DASNRAT (SEQ ID NO:31); and a VL CDR3 comprising the amino acid QQRSNWPPLT (SEQ ID NO:32).