Patent ID: 8192743

Claim:
A compound comprising Formula (I): wherein: R 1 is selected from the group consisting of polyethylene glycol, and terminal branching groups; Z and Z′ are the same or different and are independently selected from the group consisting of hydrophobic moieties, bifunctional linking moieties, wherein L 5 is a bifunctional linker and Y 4 is O, S or NR 11 , and combinations thereof; Y 1-3 are the same or different and are selected from the group consisting of O, S and NR 11 ; L 1 and L 3 are independently selected bifunctional linkers; R 3 -R 11 , R 24 and R 25 are the same or different and are selected from the group consisting of hydrogen, C 1-6 alkyls, C 2-6 alkenyls, C 2-6 alkynyls, C 3-19 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 2-6 substituted alkenyls, C 2-6 substituted alkynyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; L 2 is —C(O)(CR 30 R 31 )Y 15 (CR 32 R 33 )C(O)NR 35 — or —C(O)(CR 30 R 31 )(CR 32 R 33 )C(O)NR 35 — wherein: Y 15 is selected from the group consisting of O, S, NR 34 and CH 2 ; and R 30-35 are the same or different and are selected from the group consisting of H, alkyls, alkenyls, alkynyls, heteroalkyls and aryls; A and A′ may be the same or different and are independently selected from the group consisting of alkyl groups, leaving groups, functional groups, diagnostic agents, targeting moieties, biologically active moieties, and OH; a, g, and e are the same or different and are independently 0 or a positive integer from 1 to 5; b, c, d and d′ are the same or different and are independently 0 or 1, and m, n, o, and p are the same or different and are independently a positive integer from 1 to 6, provided that (a+e) is equal to or greater than 1, wherein weight average molecular weight of polyethylene glycol is about 40,000 Da.