Patent ID: 8101648

Claim:
A compound of the formula (VI): or a salt, tautomer or N-oxide thereof; wherein the bicyclic group: is selected from the structures C1, C5 and C6: wherein n is 0, 1, 2 or 3; R 1 is hydrogen; R 2a is hydroxy; R 3 is selected from hydrogen; halogen; cyano; C 1-5 hydrocarbyl and C 1-5 hydrocarbyloxy; wherein the C 1-5 hydrocarbyl and C 1-5 hydrocarbyloxy moieties are each optionally substituted by one or more substituents selected from hydroxy, halogen, C 1-2 alkoxy, amino, mono- and di-C 1-2 alkylamino, and aryl and heteroaryl groups of 5 to 12 ring members; R 4a is selected from hydrogen, fluorine, chlorine and methoxy; R 8 is selected from hydrogen and fluorine; and R 10 is selected from: halogen; hydroxy; trifluoromethyl; cyano; nitro; carboxy; amino; mono- or di-C 1-4 hydrocarbylamino; carbocyclic and heterocyclic groups having from 3 to 12 ring members; and a group R a —R b ; wherein: R a is a bond, O, CO, X 1 C(X 2 ), C(X 2 )X 1 , X 1 C(X 2 )X 1 , S, SO, SO 2 , NR c , SO 2 NR c or NR c SO 2 ; and R b is selected from hydrogen; carbocyclic and heterocyclic groups having from 3 to 12 ring members; and C 1-12 hydrocarbyl optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, carboxy, amino, mono- or di-C 1-8 non-aromatic hydrocarbylamino, and carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C 1-12 hydrocarbyl group may optionally be replaced by O, S, SO, SO 2 , NR c , X 1 C(X 2 ), C(X 2 )X 1 or X 1 C(X 2 )X 1 ; R c is selected from R b , hydrogen and C 1-4 hydrocarbyl; and X 1 is O, S or NR c and X 2 is ═O, ═S or ═NR c .