Patent ID: 8101583

Claim:
A compound of the formula I wherein X is O, NH, CH 2 or a bond; R1 is (C 1 -C 6 )-alkyl; R2, R2′, R3, R3′, R4, R4′, R5, R5′ are, independently of one another, H, F, Cl, Br, I, OH, —(CH 2 )—OH, CH 2 F, CHF 2 , CF 3 , NO 2 , N 3 , CN, S(O) p —R6, (C 1 -C 6 )-alkylene-S(O) p —R6, COOH, COO(C 1 -C 6 )alkyl, CONH 2 , CONH(C 1 -C 6 )alkyl, CON[(C 1 -C 6 )alkyl] 2 , (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, O—(C 1 -C 6 )-alkyl, where one, more than one, or all hydrogen(s) in the alkyl radicals may be replaced by fluorine; phenyl, —(CH 2 )-phenyl, —(CH 2 ) n -phenyl, O-phenyl, O—(CH 2 ) m -phenyl, —(CH 2 )—O—(CH 2 ) m -phenyl, where the phenyl ring may be substituted one to 3 times by F, Cl, Br, I, OH, CF 3 , NO 2 , CN, OCF 3 , O—(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, NH 2 , NH(C 1 -C 6 )-alkyl, N((C 1 -C 6 )-alkyl) 2 , SO 2 —CH 3 , COOH, COO—(C 1 -C 6 )-alkyl or CONH 2 ; wherein at least one of the radicals R2, R2′, R3, R3′, R4, R4′ has the meaning of fluorine or R5, R5′ has the meaning of CH 2 F, CHF 2 or CF 3 ; R6 is H, OH, (C 1 -C 6 )-alkyl, NH 2 , NH(C 1 -C 6 )-alkyl or N((C 1 -C 6 )-alkyl) 2 ; n is 2, 3, 4, 5 or 6; m is 1, 2, 3, 4, 5 or 6; p is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.