Patent ID: 7901680

Claim:
A DNL (dock and lock) complex comprising: a) an antibody moiety that binds to a dendritic cell antigen selected from the group consisting of CD209 (DC-SIGN), CD34, CD74, CD205, TLR 2 (toll-like receptor 2), TLR 4, TLR 7, TLR 9, BDCA-2, BDCA-3, BDCA-4, and HLA-DR, wherein the antibody moiety is attached to a DDD (dimerization and docking domain) moiety, wherein said DDD moiety has a peptide sequence from a dimerization and docking domain of protein kinase A selected from the group consisting of the amino acid sequence of SEQ ID NO: 10 and SEQ ID NO: 11; and b) a xenoantigen moiety attached to an AD (anchor domain) moiety, wherein the AD moiety has a peptide sequence from an anchoring domain of an AKAP (A-kinase anchoring protein) selected from the group consisting of the amino acid sequence of SEQ ID NO: 13; SEQ ID NO: 12; SEQ ID NO: 19; SEQ ID NO: 20; SEQ ID NO: 21; SEQ ID NO: 22; SEQ ID NO: 23; SEQ ID NO: 24; SEQ ID NO: 25; SEQ ID NO: 26; SEQ ID NO: 27 and SEQ ID NO: 28; wherein two copies of the DDD moiety form a dimer that binds to the AD moiety to form the DNL complex and wherein the DNL complex induces an immune response in vivo.