Patent ID: 7553498

Claim:
A method of treating gastroesophageal reflux disease (GERD), ulcers of the stomach or duodenum, or Zollinger-Ellison Syndrome in a human, comprising administering a plurality of pantoprazole sodium multiparticulates to a human, wherein said multiparticulates comprise a core consisting of about 45% w/w pantoprazole sodium sesquihydrate and one or more excipients comprising about 25% to 30% w/w microcrystalline cellulose, about 4% to 6% w/w polysorbate 80, about 14% to 16% w/w crospovidone, about 0.5 to 2% w/w hydroxypropyl methylcellulose, about 5% to 8% w/w sodium carbonate, and about 1 to about 2% water, an inner seal coat surrounding said core, and an enteric coating on the inner seal-coated core, said multiparticulates having an average diameter of about 0.7 mm to about 1.25 mm, and wherein following administration to humans said composition provides a geometric mean AUC of between 5451 to 5629 ng.h/mL and a geometric mean Cmax of between 1865 to 1929 ng/mL.