Patent ID: 7115249

Claim:
A process for the production of 6-L- 18 F-fluorodopa ( 18 F-FDOPA) which comprises treatment of a solid support-bound FDOPA precursor of formula (I): wherein R 1 and R 2 independently selected from C 1-6 alkyl; P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group; with a source of 18 F selected from the group consisting of 18 F 2 , 18 F—CH 3 COOF and 18 F—OF 2 ; to give the labelled tracer of formula (II) wherein P 1 , P 2 , P 3 , and P 4 are each independently hydrogen or a protecting group; optionally followed by: (i) removal of excess fluorinating agent and 18 F − ions produced in the generation of the fluorinating agent or in the reaction of a compound of formula (I) with a source of 18 F; and/or (ii) removal of any protecting groups; and/or (iii) removal of organic solvent; and/or (iv) formulation of the resultant compound of formula (II) as an aqueous solution.