Patent ID: 8049038

Claim:
A compound, or its pharmaceutically-acceptable salts, of Formula (I) below, wherein: Z is a trialicyclic adamantane as shown by Formulae (A), wherein: R, R 1 , and R 2 are each independently H or CH 3 ; C 1 -C 6 straight chain or branched alkyls, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl; C 6 -C 10 aryl unsubstituted or substituted with straight chain or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, nitro, trihaloalkyl, C 1 -C 6 acyl, C 1 -C 6 , dialkylamino, C 1 -C 6 acylamino, C 1 -C 6 mercaptoalkyl; alkylaryl (C 6 -C 10 ), such as a benzyl group unsubstituted or substituted with straight chain or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C 1 -C 6 acyl, C 1 -C 6 dialkylamino, and C 1 -C 6 mercaptoalkyl; and alkyldiaryls such as diphenylmethyl in which the aryls may be bridged by —CH 2 —CH 2 — or O or S, where the alkyldiaryls may be unsubstituted or substituted with straight chain or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C 1 -C 6 acyl, C 1 -C 6 dialkylamino, and C 1 -C 6 mercaptoalkyl; n=0 or an integer from 1 through 6; Ŕ is H or C 1 -C 4 straight-chain alkyl; Y is a moiety of Formulae (D), and shown below, wherein: R 1 is independently selected from the group consisting of straight or branched chain C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl; C 2 -C 6 alkenyl; C 2 -C 6 alkynyl; C 6 -C 10 aryl such as phenyl, naphthyl, and the like, or a heteroaryl such as furanyl, imidazolyl, pyrollyl, triazolyl, pyridyl, and the like, unsubstituted or substituted with one or more straight chain or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, nitro, trihaloalkyl, C 1 -C 6 acyl, C 1 -C 6 dialkylamino, C 1 -C 6 acylamino, C 1 -C 6 mercaptoalkyl; and straight or branched chain alkylaryl (C 6 -C 10 ), such as a benzyl group, or an alkyl heteroaryl wherein the aryl or the hetroaryl group may be unsubstituted or substituted with one or more straight chain or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C 1 -C 6 acyl, C 1 -C 6 dialkylamino, and C 1 -C 6 mercaptoalkyl, and alkyldiaryls such as diphenylmethyl in which the aryls may be bridged by —CH 2 —CH 2 — or O or S, where the alkyldiaryls may be unsubstituted or substituted with straight chain or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C 1 -C 6 acyl, C 1 -C 6 dialkylamino, and C 1 -C 6 mercaptoalkyl; and X − is a pharmaceutically-acceptable inorganic or organic counter ion.