Patent ID: 8071370

Claim:
A fusion protein comprising: a) a zinc finger DNA binding domain, wherein the zinc finger DNA binding domain has been designed or selected to recognize a particular target site in chromosomal cellular chromatin; and b) an enzymatic component of a chromatin remodeling complex that catalyzes modification of chromosomal cellular DNA or of chromatin structure, wherein the enzymatic component is selected from the group consisting of an enzyme that exhibits DNA-dependent ATPase activity, a SWI/SNF complex family member, an Mi-2 complex family member, an ISWI complex family member, a BRM family member, a BRG/BAF complex family member, a Mot-1 complex family member, a Chd-1 family member, a Chd-2 family member, a Chd-3 family member, and a Chd-4 family member.