Patent ID: 8563730

Claim:
A compound of the formula: or a tautomer, enantiomer or pharmaceutically acceptable salt thereof, wherein R 1 is heteroaryl optionally substituted through available valencies with one or more substituents independently selected from the group consisting of halo, nitro, cyano, hydroxy, alkoxy, amino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, amino(C 1-10 )alkyl, imino(C 1-3 )alkyl, oxa(C 1-5 )alkyl, oxo(C 1-5)alkyl, and -L 1 -R 22 ; R 2 is hydrogen; R 3 is -L-R 18 ; R 4 is hydrogen; R 5 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, and imino(C 1-10 )alkyl; R 6 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, amino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, imino(C 1-10 )alkyl, and -L 1 -R 22 ; or R 5 and R 6 together with the atoms to which they are attached form an aryl or heteroaryl ring which has 6 ring members and is optionally substituted through available valencies with one or more substituents independently selected from the group consisting of halo, nitro, cyano, hydroxy, alkoxy, amino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, amino(C 1-10 )alkyl, imino(C 1-10 )alkyl, and -L 1 -R 22 ; R 7 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, amino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, imino(C 1-10 )alkyl, and -L 1 -R 22 ; L is —(CH 2 )—; L 1 at each occurrence is independently absent or a linker providing 1, 2, 3, 4, 5 or 6 atom separation between R 22 and the ring to which L 1 is attached, wherein, when present, L 1 is selected from the group consisting of —(CH 2 ) s —, —NH—, —O—, —CO—, —SO 2 —, and combinations thereof; s at each occurrence is independently selected from the group consisting of 1, 2, 3, 4, 5 and 6; R 18 is tetrahydro-2H-pyran-4-yl; and R 22 at each occurrence is independently selected from the group consisting of hydroxy, amino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, (C 3-12 )cycloakyl, and phenyl optionally substituted with halo.