Patent ID: 8232398

Claim:
A process for the preparation of a compound of Formula (II), the process comprising: (a) forming a reaction mixture that comprises a compound of Formula (I) and R 9 MgX 1 such that a reaction occurs to yield a reaction product that comprises the compound of Formula (II) and an amount of the compound of Formula (I) that is unreacted according to the following reaction scheme: wherein: R 1 , R 8 R 9 , and R 10 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; R 2 and R 3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {—}OH, {—}NH 2 , {—}SH, {—}SR 10 , and {—}OR 10 ; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; X is oxygen; and X 1 is a halogen atom; (b) quenching the reaction product of step (a); (c) filtering the quenched reaction product of step (b) to form a filtrate comprising an amount of the compound of Formula (I) and an amount of the compound of Formula (II); and (d) recycling by combining the filtrate of step (c) with the reaction mixture of step (a) and repeating steps (b) and (c).