Patent ID: 7888332

Claim:
A method for inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) ion transport in a cell, the method comprising contacting the cell with a compound, wherein (a) the compound has the following formula (Ia): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein X 1 is hydrogen or a substituted or unsubstituted, saturated linear or branched alkyl; Y is hydrogen or substituted or unsubstituted, saturated linear or branched alkyl; R 1 is unsubstituted phenyl, substituted phenyl wherein phenyl is substituted with one or more of hydroxy, alkyl, and halogen, substituted or unsubstituted anthracenyl, or substituted or unsubstituted naphthalenyl; R 2 is unsubstituted phenyl, substituted phenyl, wherein phenyl is substituted with bromo or carboxy, di(hydroxy)phenyl, mono(halo)-mono(hydroxy)phenyl, mono(halo)-di(hydroxy)phenyl, mono(halo)-tri(hydroxy)phenyl, di(halo)-mono(hydroxy)phenyl, di(halo)-di(hydroxy)phenyl, di(halo)-tri(hydroxy)phenyl, mono(halo)-mono(hydroxy)-mono(alkoxy)phenyl, mono(halo)-di(hydroxy)-mono(alkoxy)phenyl, mono(halo)-mono(hydroxy)-di(alkoxy)phenyl, mono(halo)-di(hydroxy)-di(alkoxy)phenyl, di(halo)-mono(hydroxy)-mono(alkoxy)phenyl, di(halo)-di(hydroxy)-mono(alkoxy)phenyl, di(halo)-mono(hydroxy)-di(alkoxy)phenyl; and R 3 is hydrogen or substituted or unsubstituted alkyl; or (b) the compound has the following formula (Ie): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein Y″ is a substituted or unsubstituted, saturated linear or branched alkyl; or an amide or ether linker attached to a polar molecule, wherein the polar molecule is selected from a substituted or unsubstituted phenyl group, a polyoxyalkyl polyether, a polyethyleneimine, a disaccharide, a trisaccharide, a polyalkylimine, and a small amino dextran; R 1 is unsubstituted or substituted phenyl, substituted or unsubstituted quinolinyl, substituted or unsubstituted anthracenyl, or substituted or unsubstituted naphthalenyl; R 2 is unsubstituted or substituted phenyl; and R 3 is hydrogen or substituted or unsubstituted alkyl, thereby inhibiting CFTR ion transport in the cell.