Patent ID: 8414489

Claim:
A method of making an analyte sensor apparatus for implantation within a mammal comprising the steps of: providing a substrate layer; forming a plurality of analyte sensor elements on the substrate layer including a first analyte sensor element and a second analyte sensor element, wherein each of the analyte sensor elements is adapted to contact and sense analyte and comprise: at least three working electrodes disposed on the substrate layer; a glucose oxidase layer disposed upon the at least three working electrodes; an analyte modulating layer disposed on the glucose oxidase layer, wherein the analyte modulating layer comprises a hydrogel composition; an adhesion promoting layer disposed between the glucose oxidase layer and the analyte modulating layer that functions to promote adhesion between the glucose oxidase layer and the analyte modulating layer, wherein the adhesion promoting layer comprises a compound having a siloxane moiety and; forming a lid layer upon at least one of the plurality of analyte sensor elements; forming a sealed aperture on the lid layer; forming at least one analyte sensor membrane disposed upon at least one of the plurality of analyte sensor elements in a manner that can reversibly prevent an analyte from contacting the at least one of the plurality of analyte sensor elements, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and forming at least one structure operatively coupled to the analyte sensing apparatus for relaying information to and away from the analyte sensing apparatus, wherein the analyte sensing device is made so that the first and second analyte sensor elements in the analyte sensing device sense different analytes, so that an analyte sensor apparatus is made.