Patent ID: 6921752

Claim:
A method for treating chronic bronchitis in a horse, which method comprises administering to the affected horse a therapeutically effective amount of a LTB 4 antagonist, wherein the LTB 4 antagonist is a compound of formula I, wherein A denotes a group of formula —O—C m H 2m —O—(PHE) n — (II) wherein m is an integer from 2 to 6, n is 0 or 1, PHE denotes a 1,4-phenylene group optionally substituted by one or two C 1 -C 8 alkyl groups; or A denotes a group of formula R 1 denotes H, OH, CN, COR 10 , COOR 10 or CHO; R 2 denotes H, Br, Cl, F, CF 3 , CHF 2 , OH, HSO 3 —O, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 5 -C 7 -cycloalkyl, CONR 8 R 9 , aryl, O-aryl, CH 2 -aryl, CR 5 R 6 -aryl, or C(CH 3 ) 2 —R 7 , R 3 denotes H, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, OH, Cl or F, R 4 denotes H or C 1 -C 6 -alkyl; R 5 denotes C 1 -C 4 -alkyl, CF 3 , CH 2 OH, COOH or COO(C 1 -C 4 -alkyl); R 6 denotes H, C 1 -C 4 -alkyl or CF 3 ; R 7 denotes CH 2 OH, COOH, COO(C 1 -C 4 -alkyl), CONR 8 R 9 or CH 2 NR 8 R 9 ; R 8 denotes H, C 1 -C 6 -alkyl, phenyl, phenyl-(C 1 -C 6 -alkyl), COR 10 , COOR 10 , CHO, CONH 2 , CONHR 10 , SO 2 —(C 1 -C 6 -alkyl), SO 2 -phenyl, while the phenyl group may be mono- or disubstituted by Cl, F, CF 3 , C 1 -C 4 -alkyl, OH and/or C 1 -C 4 -alkoxy; R 9 denotes H or C 1 -C 6 -alkyl; or R 8 and R 9 together represent a C 4 -C 6 -alkylene group; R 10 denotes C 1 -C 6 -alkyl, C 5 -C 7 -cycloalkyl, aryl, heteroaryl, aralkyl or heteroaryl-(C 1 -C 6 -alkyl), while the aryl groups mentioned in groups R 2 and R 10 denote phenyl or naphthyl, the heteroaryl groups denote pyrrole, pyrazote, imidazole, furanyl, thienyl, pyridine or pynmidine and may each be mono- or polysubstituted by Cl, F, CF 3 , C 1 -C 4 -alkyl, OH, HSO 3 —O or C 1 -C 4 -alkoxy, and the pharmacologically acceptable acid addition salts thereof, the glycosides and O-sulphates thereof.