Patent ID: 8759539

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein Ar is an aryl or heteroaryl, wherein the aryl or heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of: —OC 1-10 alkyl, —OC 3-6 cycloalkyl, —O-heteroaryl, —O-aryl, aryl, aryl substituted with one to three halogen, aryl substituted with one to three C 1-10 alkyl, heteroaryl, heteroaryl substituted with one to three halogen, heteroaryl substituted with one to three C 1-10 alkyl, halogen, —CO 2 H, —C 1-10 alkoxycarbonyl, —CN, —CF 3 , NH 2 pyrrolidone, cycloheteroalkyl, C 1-10 alkyl, C 3-6 cycloalkyl, and C 3-6 cycloalkyl substituted with one to three C 1-10 alkyl; X is O, NH or OCH 2 ; R 1 is SO 2 H, CONHC 1-10 alkyl, —C 1-10 alkoxycarbonyl, aroyl, heteroaroyl, aryl, heteroaryl, cycloalkyl or cycloheteroalkyl wherein the CONHC 1-10 alkyl, —C 1-10 alkoxycarbonyl, aroyl, heteroaroyl, aryl, heteroaryl, cycloalkyl or cycloheteroalkyl are optionally substituted with one or more substituents independently selected from the group consisting of: —OH, —OC 1-10 alkyl, —OC 3-6 cycloalkyl, —O heteroaryl, —O aryl, aryl substituted with one to three halogen, aryl, aryl substituted with one to three C 1-10 alkyl, heteroaryl, halogen, SO 2 C 1-10 alkyl, SO 2 -aryl, SO 2 -aryl-C 1-10 alkyl, —C(O)H, —C(O)C 1-10 alkyl, —C(O)C 3-6 cycloalkyl, —C(O) cycloalkyl, —C(O) heteroaryl, —C(O) aryl, —OC(O)H, —OC(O)C 1-10 alkyl, —OC(O)C 3-6 cycloalkyl, —OC(O) cycloalkyl, —OC(O) heteroaryl, —OC(O) aryl, —NH 2 , CONH—C 1-10 alkyl-aryl, —CONH 2 , —CO 2 H, —C 1-10 alkoxycarbonyl, —CO 2 C 1-10 alkylaryl, —CN, —CF 3 , —OCF 3 , —OCHF 2 , cycloheteroalkyl, pyrrolidone, C 1-10 alkyl-OH, C 1-10 alkyl, and C 3-6 cycloalkyl.