Patent ID: 8901076

Claim:
A recombinant binding protein comprising at least one ankyrin repeat domain, wherein said ankyrin repeat domain binds VEGF-A165 with Kd below 10 −7 M, and wherein said ankyrin repeat domain comprises a repeat module with the ankyrin repeat sequence motif 1 D 23 GWTPLHL 4 ADLG 5 LEIVEVLLK 6 GADVN 7 (SEQ ID NO: 4) wherein 1 represents an amino acid residue selected from the group consisting of K, T and Y; 2 represents the amino acid residue N or M; 3 represents the amino acid residue T or F; 4 represents the amino acid residue S or A; 5 represents the amino acid residue H or R; 6 represents an amino acid residue selected from the group consisting of A, Y, H, and N; and 7 represents the amino acid residue A or T.