Patent ID: 8428884

Claim:
A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of: (a) providing a molecular model of at least a portion of an RNA microhelix binding site of a large subunit of a ribosome created from (i) the atomic co-ordinates for the Haloarcula marismortui large ribosomal subunit found on Replacement Disk 1 under file name microhelix.txt or microhelixa.txt, or (ii) atomic co-ordinates derived by molecular modeling from the Haloarcula marismortui atomic co-ordinates found on Replacement Disk 1 under file name microhelix.txt or microhelixa.txt; (b) using the molecular model to identify a candidate molecule that binds to at least a portion of the RNA microhelix binding site of the molecular model, wherein the RNA microhelix binding site comprises at least a portion of the E-site of the large ribosomal subunit; and (c) producing the candidate molecule identified in step (b).