Patent ID: 8404692

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein Z is NR 11 , NHCO, NHSO 2 , NHCH 2 , CH 2 , CH 2 CH 2 , or CH═CH; X is a hydrocarbyl group optionally substituted by one or more R 12 groups; R 10 and R 11 are each independently H or alkyl; R 1 -R 4 are each independently H or (CH 2 ) m R 12 , where m is 0, 1, 2, or 3; each R 12 is independently (CH 2 ) a R 16 , where each R 16 is independently selected from O(CH 2 ) b R 13 , R 13 , COR 13 , COOR 13 , CN, CONR 13 R 14 , NR 13 R 14 , NR 13 COR 14 , SR 13 , SOR 13 , SO 2 R 13 , NR 13 SO 2 R 14 , SO 2 OR 13 , SO 2 NR 13 R 14 , halogen, CF 3 , and NO 2 , and wherein each a is 0, 1, 2, or 3 and b is 0, 1, 2, or 3; R 13 and R 14 are each independently H or (CH 2 ) n R 15 , where n is 0, 1, 2, or 3; and each R 15 is independently selected from alkyl, cycloalkyl, heteroaryl, aralkyl, aryl and heterocycloalkyl, each of which may be optionally substituted by one or more substituents selected from halogen, OH, CN, COO-alkyl, aralkyl, SO 2 -alkyl, SO 2 -aryl, COOH, CO-alkyl, CO-aryl, NH 2 , NH-alkyl, N(alkyl) 2 , CF 3 , alkyl and alkoxy, wherein said alkyl and alkoxy groups may be further substituted by one or more OH groups.