Patent ID: 7226913

Claim:
A pharmaceutical composition comprising a compound of the formula (I): wherein (a) each R is individually hydrogen, C 1 –C 6 alkyl, C 3 –C 7 cycloalkyl, phenyl or phenyl(C 1 –C 3 )-alkyl; (b) X is —CH 2 OH, —CO 2 R 2 , —OC(O)R 2 , —CH 2 OC(O)R 2 or —C(O)NR 3 R 4 ; (c) each of R 2 , R 3 and R 4 is individually H, C 1-6 -alkyl; C 1-6 -alkyl substituted with 1–3 C 1-6 -alkoxy, C 3 –C 7 cycloalkyl, C 1-6 -alkylthio, halogen, hydroxy, amino, mono(C 1-6 -alkyl)amino, di(C 1-6 -alkyl)amino, or C 6-10 -aryl, wherein aryl may be substituted with 1–3 halogen, C 1-6 -alkyl, hydroxy, amino, mono(C 1-6 -alkyl)amino, or di(C 1-6 -alkyl)amino; C 6-10 -aryl; or C 6-10 -aryl substituted with 1–3 halogen, hydroxy, amino, mono(C 1-6 -alkyl)amino, di(C 1-6 -alkyl)amino or C 1-6 -alkyl; (d) R 1 is (X-(Z)-) n [(C 3 –C 10 )cycloalkyl]-(Z′)- wherein Z and Z′ are individually (C 1 –C 6 )alkyl, optionally interrupted by 1–3 S or non-peroxide O, or is absent, and n is 1–3; or a pharmaceutically acceptable salt thereof; in combination with a carrier; wherein the composition is suitable for oral administration.