Patent ID: 6900206

Claim:
A compound of Formula I, including pharmaceutically acceptable salts thereof, wherein: Z is Q is selected from the group consisting of: —W— is R 1 , R 2 , R 3 , R 4 , and R 5 , are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, COOR 8 , XR 9 and B; R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 and R 22 are each independently H or (C 1-6 )alkyl; wherein (C 1-6 )alkyl is optionally substituted with one to three same or different members selected from the group consisting of halogen, amino, OH, CN and NO 2 ; m is 1 or 2; R 6 is O or does not exist; R 7 is (CH 2 ) n R 10 , SO 2 NH 2 , SO 2 NHMe or SO 2 NMe 2 ; n is 0-6; R 10 is selected from the group consisting of H, (C 1-6 )alkyl, —C(O)—(C 1-6 )alkyl, C(O)-phenyl and CONR 11 R 12 ; R 11 and R 12 are each independently H, (C 1-6 )alkyl or phenyl; — represents a carbon-carbon bond or does not exist; A is NR 13 R 14 ; R 13 and R 14 are independently selected from the group consisting of hydrogen, (C 1-6 )alkyl, (C 1-6 )cycloalkyl, and phenyl; or R 13 and R 14 taken together with the nitrogen atom to which they are attached forms a heteroalicyclic ring having 3 to 6 atoms; wherein heteroalicyclic is selected from the group consisting of azetidinyl, piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, tetrahydrofuranyl and tetrahydropyranyl, B is selected from the group consisting of (C 1-6 )alkyl, (C 3-6 )cycloalkyl, C(O)NR 23 R 24 , phenyl and heteroaryl; wherein said heteroaryl is selected from the group consisting of pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, thienyl, benzothienyl, thiazolyl isothiazolyl, oxazolyl, benzooxazolyl, isoxazolyl, imidazolyl, benzoimidazolyl, 1H-imidazo[4,5-b]pyridin-2-yl, 1H-imidazo[4,5-c]pyridin-2-yl, oxadiazolyl, thiadiazolyl, pyrazolyl, tetrazolyl, tetrazinyl, triazinyl and triazolyl; R 8 and R 9 are independently selected from the group consisting of hydrogen and (C 1-6 )alkyl; X is selected from the group consisting of NR 31 , O and S; R 23 , R 24 and R 31 are independently selected from the group consisting of hydrogen, (C 1-6 )alkyl, and heteroaryl; wherein said heteroaryl is selected from the group consisting of furanyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, tetrazolyl, triazolyl, pyridinyl, pyrazinyl, pyridazinyl, and pyrimidinyl.