Patent ID: 7294737

Claim:
A process of manufacturing a compound of Formula I or its ester or salt thereof, wherein Z 1 , Z 2 , Z 3 , and Z 4 are independently selected from the group consisting of hydrogen and alkyl, said alkyl optionally substituted by hydroxy, alkyl, alkenyl, acyl, nitro, amino, halo, carboxy and cyano; Z 5 and Z 6 are the same or different and independently selected from the group consisting of alkyl, alkenyl, and aryl all of which can be optionally substituted by hydroxy, alkyl, alkenyl, acyl, nitro, amino, halo, carboxy and cyano; M is selected from the group consisting of hydrogen, an optionally substituted unsaturated acyl having from 1 to 18 carbon atoms, and an optionally substituted saturated acyl having from 1 to 18 carbon atoms, said optionally substituted unsaturated acyl and optionally substituted saturated acyl optionally containing a polar or charged functionality; and J is selected from the group consisting of an optionally substituted unsaturated acyl having from 1 to 18 carbon atoms and an optionally substituted saturated acyl having from 1 to 18 carbon atoms, said optionally substituted unsaturated acyl and optionally substituted saturated acyl optionally containing a polar or charged functionality; the process comprising: reacting a compound of Formula II wherein Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and Z 6 are as previously defined, with a compound of Formula III, wherein Y is R or NR 2 R 5 ; R 1 , R 2 , R 3 and R 4 and R 5 are independently selected from an optionally substituted C 1 -C 10 alkyl or an optionally substituted C 2 -C 10 alkenyl; R 1 and R 2 can optionally come together to form a ring; R 3 and R 4 can optionally come together to form a ring; and a compound selected from the group consisting of a saturated or unsaturated acyl halide, saturated or unsaturated carboxylic acid anhydride and a saturated or unsaturated activated carboxylic acid ester, all of which may optionally be substituted by one or more substituents selected from the group consisting of protected hydroxy, alkyl, alkenyl, acyl, nitro, protected amino, amino, halo, protected carboxy and cyano; and separating and isolating the compound of Formula I.