Patent ID: 8822649

Claim:
A protein comprising a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second polypeptide or polypeptide domain having a second specific binding activity for Glucose Transporter 2 (GLUT2) or an ectodomain thereof expressed on a pancreatic beta-cell surface, wherein the first and second polypeptide or polypeptide domain are independently an antibody molecule or a specific-binding fragment thereof, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein the protein is multivalent in binding to CTLA-4, wherein said agonist response in the T cell reduces immunoreactivity against pancreatic beta cells.