Patent ID: 8808532

Claim:
A method of making a sensor apparatus for implantation within a mammal comprising the steps of: providing a base layer; forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode formed from a sputtered platinum composition; forming an electrolyte retaining layer in operable contact with the conductive layer, wherein the electrolyte retaining layer is formed from a composition selected to absorb 10% 10 to 50% water by weight; forming an analyte sensing layer disposed over the conductive layer, wherein the analyte sensing layer comprises glucose oxidase entrapped within a poly(vinyl alcohol)-styrylpyridinium (PVA-SbQ) polymer matrix; and forming an analyte modulating layer disposed over the analyte sensing layer, wherein the method comprises modifying a surface of the analyte sensing layer using a plasma deposition process so that chemical moieties on the surface are crosslinked.