Patent ID: 8748573

Claim:
A method of treating chronic constipation or constipation-predominant irritable bowel syndrome in a patient in need thereof, comprising administering to the patient an oral, solid pharmaceutical dosage form comprising: between 100 μg and 300 μg of a peptide consisting of the amino acid sequence Cys 1 Cys 2 Glu 3 Tyr 4 Cys 5 Cys 6 Asn 7 Pro 8 Ala 9 Cys 10 Thr 11 Gly 12 Cys 13 Tyr 14 (SEQ ID NO:1) or a pharmaceutically acceptable salt thereof, wherein the peptide includes disulfide bonds between Cys 1 and Cys 6 , Cys 2 and Cys 10 , and Cys 5 and Cys 13 ; leucine in a molar ratio of leucine to the peptide between 40:1 and 20:1; and Ca 2+ or a salt thereof in a molar ratio of Ca 2+ the peptide between 70:1 and 50:1.