Patent ID: 7754730

Claim:
A method of treating a subject having Parkinson's Disease, which comprises administering to the subject a therapeutically effective dose of the compound having the structure of Formula I or a pharmaceutically acceptable salt thereof, wherein (a) R 2 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl, furyl, pyridyl, thiazole and optionally substituted C 3-7 cycloalkyl, or —NR 24 R 25 Wherein R 24 and R 25 are independently selected from H, C 1-8 straight or branched chain alkyl, arylalkyl, C 3-7 cycloalkyl, carboxyalkyl, aryl, furyl, pyridyl and thiazole, (b) R 3 is from one to four groups independently selected from the group consisting of: hydrogen, halo, C 1-8 straight or branched chain alkyl, arylalkyl, C 3-7 cycloalkyl, C 1-8 alkoxy, cyano, C 1-4 carboalkoxy, trifluoromethyl, C 1-8 alkylsulfonyl, halogen, nitro, hydroxy, trifluoromethoxy, C 1-8 carboxylate, aryl, piperazine, morpholine, piperidine, furyl, pyridyl, —NR 11 R 12 , wherein R 11 and R 12 are independently selected from H, C 1-8 straight or branched chain alkyl, arylalkyl, C 3-7 cycloalkyl, carboxyalkyl, aryl, heteroaryl, and heterocyclyl or R 10 and R 11 taken together with the nitrogen form a piperazine, morpholine, piperidine, furyl, pyridyl group, —NR 13 COR 14 , wherein R 13 is selected from hydrogen or alkyl and R 14 is selected from hydrogen, alkyl, substituted alkyl, C 1-3 alkoxyl, carboxyalkyl, aryl, arylalkyl, piperazine, morpholine, piperidine, furyl, pyridyl, R 15 R 16 N(CH 2 ) p —, or R 15 R 16 NCO(CH 2 ) p —, wherein R 15 and R 16 are independently selected from H, OH, alkyl, and alkoxy, and p is an integer from 1-6, wherein the alkyl group may be substituted with carboxyl, alkyl, aryl, substituted aryl, piperazine, morpholine, piperidine, furyl, pyridyl, substituted piperazine, morpholine, piperidine, furyl, pyridyl hydroxamic acid, sulfonamide, sulfonyl, hydroxy, thiol, alkoxy or arylalkyl, or R 13 and R 14 taken together with the carbonyl form a carbonyl containing piperazine, morpholine, piperidine, furyl, pyridyl, group; (c) R 4 is selected from the group consisting of —OR 17 , and —NR 17 R 18 , Wherein R 17 and R 18 are independently selected from hydrogen, and optionally substituted C 1-6 alkyl or aryl; and (d) X is selected from C═S, C═O; CH 2 , CHOH, CHOR 19 , or CHNR 20 R 21 where R 19 , R 20 , and R 21 are selected from optionally substituted C 1-8 straight of branched chain alkyl, wherein the substituents on the alkyl group are selected from C 1-8 alkoxy, hydroxy, halogen, amino, cyano, or NR 22 R 23 wherein R 22 and R 23 are independently selected from the group consisting of hydrogen, C 1-8 straight or branched chain alkyl, C 3-7 cycloalkyl, benzyl, aryl.