Patent ID: 7507813

Claim:
A process for the preparation of amorphous cefuroxime axetil having an average particle size of between about 20 nm to about 30 μm, comprising the steps of: (a) providing a cefuroxime axetil solution and a suitable antisolvent; (b) spraying the cefuroxime axetil solution via an atomizer into a stirred reactor which contains the antisolvent, thereby precipitating and crystallizing the cefuroxime axetil into a slurry via antisolvent recrystallization; (c) collecting the slurry of cefuroxime axetil obtained in step (b); and (d) filtering and then drying the filtered slurry of cefuroxime axetil to obtain cefuroxime axetil powder in an amorphous form wherein the cefuroxime axetil powder has an average particle size of between about 20 nm to about 30 μm.