Patent ID: 8324211

Claim:
A compound of Formula IV, wherein: R is H, —R 1 , —R 1 —R 2 —R 3 , —R 1 —R 3 , or —R 2 —R 3 ; R 1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, and is optionally substituted with R 1′ ; R 1′ is lower alkyl, hydroxy, lower hydroxyalkyl, lower alkoxy, halogen, nitro, amino, cycloalkyl, heterocycloalkyl, cyano, or lower haloalkyl; R 2 is —C(=O), —C(=O)O, —C(=O)N(R 2′ ), —(CH 2 ) q , or —S(=O) 2 ; R 2′ is H or lower alkyl; q is 1, 2, or 3; R 3 is H or R 4 ; R 4 is lower alkyl, lower alkoxy, lower heteroalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl, and is optionally substituted with one or more lower alkyl, hydroxy, oxo, lower hydroxyalkyl, lower alkoxy, halogen, nitro, amino, cyano, lower alkylsulfonyl, or lower haloalkyl; X is CH or N; each Y 1 is independently Y 1a or Y 1b ; Y 1a is halogen; Y 1b is lower alkyl, optionally substituted with one or more Y 1b′ ; Y 1b′ is hydroxy, lower alkoxy, or halogen; n is 0, 1, 2, or 3; Y 2 is Y 2a or Y 2b ; Y 2a is H or halogen; Y 2b is lower alkyl, optionally substituted with one or more Y 2b′ ; Y 2b ′ is hydroxy, lower alkoxy, or halogen; Y 3 is halogen or lower alkyl, wherein the lower alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, lower alkoxy, amino, and halogen; m is 0 or 1; Y 4 is Y 4a , Y 4b , Y 4c , or Y 4d ; Y 4a is H or halogen; Y 4b is lower alkyl, optionally substituted with one or more substituents selected from the group consisting of haloalkyl, halogen, hydroxy, amino, cyano and lower alkoxy; Y 4c is lower cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower haloalkyl, halogen, hydroxy, amino, and lower alkoxy; and Y 4d is amino, optionally susbstituted with one or more lower alkyl; or a pharmaceutically acceptable salt thereof.