Patent ID: 7601709

Claim:
A compound having the Formula I or a pharmaceutically acceptable salt or ester thereof: wherein: A is selected from the group consisting of H, —(C═O)—R 2 , —(C═O)—O—R 1 , —C═O)—NH—R 2 , —C(═S)—NH—R 2 , —S(O) 2 —R 2 , —(C═NR 1 )—R 1 , and —(C═NR 1 )—NH—R 1 ; G is selected from the group consisting of —OH, —O—(C 1 -C 12 alkyl), —NHS(O) 2 —R 1 , —(C═O)—R 1 , —(C═O)—O—R 1 , and —(C═O)—NH—R 1 ; L is absent; j is 0, 1, 2, 3, or 4; m is 0, 1, or 2; s is 0, 1 or 2; R 1 is selected form the group consisting of H, C 1 -C 6 alkyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, and substituted heterocycloalkyl; R 2 is selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 12 cycloalkyl, alkylamino, dialkylamino, arylamino, diarylamino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, and substituted heterocycloalkyl; R 3 and R 4 are each independently selected from the group consisting of hydrogen, OH, CH 3 , CN, SH, halogen, NO 2 , NH 2 , amide, methoxy, trifluoromethoxy, and trifluoromethyl; E is selected from —CH═CH— or —CH 2 —CH 2 —; and W is a substituted or unsubstituted heterocyclic ring system; wherein the radical being joined to the rest of the molecule via a ring atom.