Patent ID: 8569507

Claim:
A compound having formula (I) and the salts and stereoisomers thereof, wherein R 1 is hydrogen, nitro, cyano, azido, polyhaloC 1-6 alkyl, and polyhaloC 1-6 alkoxy; R 2 is C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or Het; C 2-6 alkenyl optionally substituted with C 3-7 cycloalkyl, aryl or Het; aryl; Het; or —NR 4a R 4b , wherein R 4a and R 4b are, each independently, C 1-6 alkyl, or R 4a and R 4b together with the nitrogen to which they are attached form a 5- or 6-membered saturated heterocyclic ring; R 3 is hydrogen, C 1-6 alkylcarbonyl, C 1-6 alkyl optionally substituted with aryl, C 1-6 alkoxy -C 1-6 alkyl, or C 3-7 cycloalkyl, C 1-6 alkyl optionally substituted with Het; R 4 is hydrogen, hydroxy, halo, nitro, cyano, carboxyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy -C 1-6 alkyl or C 3-7 cycloalkyl, C 1-6 alkylcarbonyl, amino, mono- or diC 1-6 alkylamino, azido, mercapto, polyhaloC 1-6 alkyl, and polyhaloC 1-6 alkoxy, C 1-6 alkyl optionally substituted with aryl or Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or Het; C 2-6 alkenyl optionally substituted with C 3-7 cycloalkyl, aryl or Het; aryl; Het; or —NR 4a R 4b ,wherein R 4a and R 4b are, each independently, C 1-6 alkyl, or R 4a and R 4b together with the nitrogen to which they are attached form a 5- or 6-membered saturated heterocyclic ring; n is one, two, three, four or five; p is one, two, three, four or five, independently of n; each aryl as a group or part of a group is phenyl or naphthalenyl, each optionally substituted with one, two or three substituents selected from halo, hydroxy, nitro, cyano, carboxyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkylcarbonyl, amino, mono- or diC 1-6 alkylamino, azido, mercapto, polyhaloC 1-6 alkyl, and polyhaloC 1-6 alkoxy; and each Het as a group or part of a group is a monocyclic ring with 5 or 6 ring atoms or a bicyclic ring structure comprising a 6 membered ring fused to a 4, 5, or 6 membered ring; each of the rings being saturated, partially unsaturated, or completely unsaturated; at least one of the rings containing 1 to 4 heteroatoms each independently selected from nitrogen, oxygen and sulphur; and any one of the rings being optionally substituted with one, two or three substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, carboxyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkylcarbonyl, amino, mono- or diC 1-6 alkylamino, azido, mercapto, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkoxy, and C 3-7 cycloalkyl.