Patent ID: 8729078

Claim:
A compound of Formula I, wherein: is either a single or double bond; A is 5-membered heteroaryl or a 5,6-membered bicyclic heteroaryl, wherein the CONH 2 is attached to the 5-membered heteroaryl, each optionally substituted with one or more A′; A′ is —NHR or R 4 ; R is H, —R 1 , —R 1 —R 2 —R 3 , or —R 1 —R 3 ; or —R 2 —R 3 ; R 1 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, or heteroaryl fused with a heterocycloalkyl, each of which is optionally substituted with one or more R 1′ or R 1″ ; each R 1′ is independently halo, nitro, cyano, lower alkyl sulfonamido, —S(O) 2 , or oxo; each R 1″ is independently lower alkyl, cycloalkyl, heterocycloalkyl, lower alkoxy, amino, or amido, each optionally substituted with one or more R 1′″ ; each R 1′″ is independently hydroxy, halo, amino, alkyl amino, dialkyl amino, or heterocycloalkyl; R 2 is —C(═O), —C(═O)O, —C(═O)NR 2′ , —NHC(═O)O, —C(R 2′ ) 2 , —O, —C(═NH)NR 2′ , or —S(═O) 2 ; each R 2′ is independently H or lower alkyl; R 3 is H or R 4 ; R 4 is lower alkyl, lower haloalkyl, lower alkoxy, amino, lower alkyl amino, lower dialkyl amino, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, heterocycloalkyl alkyl, bicyclic cycloalkyl, bicyclic heterocycloalkyl, spirocycloalkyl, or spiroheterocycloalkyl, each of which is optionally substituted with one or more lower alkyl, halo, lower alkyl amino, lower dialkyl amino, hydroxy, hydroxy lower alkyl, lower alkoxy, halo, nitro, amino, amido, acyl, cyano, oxo, guanidino, hydroxylamino, carboxy, carbamoyl, carbamate, halo lower alkoxy, or halo lower alkyl, wherein two lower alkyl groups may together form a ring; Q is CH or N; X is CH, N, or N(X′); X′ is lower alkyl; Y 0 is H, halogen or lower alkyl; Y 1 is Y 1a , Y 1b , Y 1c , or Y 1d ; Y 1a is H or halogen; Y 1b is lower alkyl, optionally substituted with one or more substituents selected from the group consisting of lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy; Y 1c is lower cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy; Y 1d is amino, optionally substituted with one or more lower alkyl, alkoxy lower alkyl, or hydroxy lower alkyl; Y 2 is H, halogen or lower alkyl; Y 3 is H, halogen, lower alkyl, lower haloalkyl, lower alkoxy, or lower hydroxy alkyl; and Y 4 is H, lower alkyl, or lower hydroxyalkyl; or a pharmaceutically acceptable salt thereof.