Patent ID: 7064209

Claim:
A process for producing an optically active (E)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-5-hydroxy-3-oxohept-6-enoic acid ester of formula (III) wherein R is an alkyl having 1 to 4 carbon atoms, which comprises reacting 1,3-bis(trimethylsilyloxy)-1-alkoxybuta-1,3-diene of formula (I) wherein R is as defined above, with (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-prop-2-en-1-al of formula (II) in the presence of an optically active binaphthol-titanium complex prepared by reacting 1,1′-bi-2-naphthol with titanium tetraisopropoxide, a metal salt and an amine, and then subjecting the resulting reaction product to desilylation.