Patent ID: 7381733

Claim:
A method for the inhibiting dopamine reuptake associated with reduced blood flow to the brain or with an instance of a temporary break in blood supply to the brain in a subject, comprising administering to said subject a therapeutically effective amount of a tropane compound having dopamine reuptake inhibitor activity or a pharmaceutically acceptable salt thereof, wherein the tropane compound is a compound of the general formula (I) or a pharmaceutically acceptable addition salt thereof or the N-oxide thereof, wherein: R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R 3 is CH 2 —X—R′ wherein X is O or S and R′ is methyl, ethyl, propyl, or cyclopropylmethyl, or R 3 is CH═NOR′ wherein R′ is hydrogen or alkyl, or R 3 is 1,2,4-oxadiazol-5-yl which may be substituted in the 3 position with alkyl; and R 4 is 3,4-methylenedioxyphenyl or R 4 is phenyl, benzyl, naphthyl, or heteroaryl all of which may be substituted one or more times with substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, and heteroaryl.