Patent ID: 7560563

Claim:
A production method of a pyridine compound having a substituent at the 2-position of an aromatic heterocyclic structure, which is represented by the formula (III′) wherein R 2 , R 3 , R 4 and R 5 are each a hydrogen atom, a halogen atom, an alkyl group optionally having substituent(s), an aryl group optionally having substituent(s), an alkoxyl group optionally having substituent(s), an aryloxy group optionally having substituent(s), an acyloxy group optionally having substituent(s), an alkylthio group optionally having substituent(s), an arylthio group optionally having substituent(s), an arylthio group optionally having substituent(s), a protected amino group optionally having substituent(s), a nitro group, a cyano group, an acyl group optionally having substituent(s), an alkoxycarbonyl group optionally having substituent(s), a carbamoyl group optionally having substituent(s) or a sulfonyl group optionally having substituent(s), or R 2 and R 3 ,R 3 and R 4 , or R 4 and R 5 optionally form, together with a carbon atom bonded thereto, a ring optionally having substituent(s), is an aromatic heterocycle optionally having substituent(s), wherein the aromatic heterocycle is selected from the group consisting of a pyridine ring, pyrimidine ring, a pyridazine ring, a pyrazine ring, a thiophene ring, a furan ring, a pyrrole ring, an imidazole ring, a pyrazole ring, a thiazole ring, an oxazole ring and an isoxazole ring; and the substituent(s) are selected from the group consisting of a halogen atom, an alkyl group optionally having substituent(s), an aryl group optionally having substituent(s), an alkoxyl group optionally having substituent(s), an aryloxy group optionally having substituent(s), an acyloxy group optionally having substituent(s), an alkylthio group optionally having substituent(s), an arylthio group optionally having substituent(s), an acylthio group optionally having substituent(s), a protected amino group optionally having substituent(s), a nitro group, a cyano group, an acyl group optionally having substituent(s), an alkoxycarbonyl group optionally having substituent(s), a carbamoyl group optionally having substituent(s) and a sulfonyl group optionally having substituent(s), which comprises reacting a 2-sulfonylpyridine compound represented by the formula (I) wherein R 1 is an alkyl group optionally having substituent(s) or an aryl group optionally having substituent(s), and R 2 , R 3 , R 4 and R 5 are as defined above, with an organometallic compound represented by the formula (II′) wherein M is an atom of an element belonging to Group 1 , Group 2 , Group 12 or Group 13 of the periodic table except a hydrogen atom, and is as defined above.