Patent ID: 8153128

Claim:
An isolated antibody, wherein the antibody binds IL-6:IL-6Ra complex formed by IL-6 and IL-6Ra, and does not bind either IL-6 or IL-6Ra alone, wherein the antibody comprises a set of CDRs: HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein: a) HCDR1 comprises the amino acid sequence of SEQ ID NO: 3, HCDR2 comprises the amino acid sequence of SEQ ID NO: 4, HCDR3 comprises the amino acid sequence of SEQ ID NO: 5, LCDR1 comprises the amino acid of sequence SEQ ID NO: 8, LCDR2 comprises the amino acid sequence of SEQ ID NO: 9, and LCDR3 comprises the amino acid sequence of SEQ ID NO: 10; or b) HCDR1 comprises the amino acid sequence of SEQ ID NO: 13, HCDR2 comprises amino the acid sequence of SEQ ID NO: 14, HCDR3 comprises the amino acid sequence of SEQ ID NO: 15, LCDR1 comprises the amino acid of sequence SEQ ID NO: 18, LCDR2 comprises the amino acid sequence of SEQ ID NO: 19, and LCDR3 comprises the amino acid sequence of SEQ ID NO: 20; or c) HCDR1 comprises the amino acid sequence of SEQ ID NO: 23, HCDR2 comprises amino the acid sequence of SEQ ID NO: 24, HCDR3 comprises the amino acid sequence of SEQ ID NO: 25, LCDR1 comprises the amino acid of sequence SEQ ID NO: 28, LCDR2 comprises the amino acid sequence of SEQ ID NO: 29, and LCDR3 comprises the amino acid sequence of SEQ ID NO: 30.