Patent ID: 7994174

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: ring Z is thiazolyl or thiadiazolyl, wherein Z is optionally substituted with up to q occurrences of R Z substitutents, wherein each R Z is independently selected from R 1 , R 2 , R 4 , or R 5 ; and q is 0-2; W and Y 1 each is independently CH or N, provided that at least one of W and Y 1 is N; x and y each is independently 0-3; provided that x+y is 2, 3, or 4; w is 0-4; v is 0 or 1; z is 0-4; V is a bond; X is a bond or, —NH— C(R 2 ) 2 ; Q is a bond or a C1-C6 straight or branched alkylidene chain, wherein up to two non-adjacent methylene units of Q are optionally and independently replaced by —O—, —S—, or —NR 2 —; R Q is a phenyl, quinoline, 1,2,3,4-tetrahydroquinoline, indoline or indole ring; wherein R Q is optionally substituted with up to 4 substituents independently selected from R 1 , or R 2 ; R 11 is R 2 or Y; R 22 is R 1 or R 2 ; R 1 is oxo or (CH 2 ) n —Y; n is 0, 1 or 2; Y is halo, CN, NO 2 , CF 3 , OCF 3 , or OH; and R 2 is hydrogen or C1-C6 aliphatic, wherein each R 2 is optionally substituted with up to 2 substituents independently selected from R 1 .