Patent ID: 8785127

Claim:
A method for determining sequence information for a polynucleotide, comprising: (a) providing an array of DNA molecules, wherein each DNA molecule comprises a fragment of said polynucleotide; (b) contacting the array with a set of informative oligonucleotide probes, wherein each probe comprises a label and a nucleotide sequence comprising the formula N x B y N z , wherein: (i) each N is independently a degenerate base; (ii) each B is independently an informative base; (iii) x and z are each at least one; and (iv) y is 2 to 20; (c) detecting labeled probes once the probes have hybridized to DNA molecules in the array, thereby obtaining data indicating which of the labeled probes are hybridized to each DNA molecule; and (d) processing the data to obtain said sequence information for the polynucleotide.