Patent ID: 7399779

Claim:
A compound having the structure of Formula I: and its pharmaceutically acceptable salts, pharmaceutically acceptable enantiomers, diastereomers, or N-oxides, wherein Ar represents an aryl or a heteroaryl ring having 1-2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl (C 1 -C 4 ) amino or N-lower alkyl(C 1 -C 4 ) amino carbonyl; R 1 represents a hydrogen, hydroxy, hydroxy methyl, amino, alkoxy, carbamoyl or halogen (e.g. fluorine, chlorine, bromine and iodine); R 2 represents alkyl, C 3 -C 7 cycloalkyl ring, a C 3 -C 7 cyclo alkenyl ring, an aryl or a heteroaryl ring having 1 to 2 hetero atoms selected from a group consisting of oxygen, sulphur and nitrogen atoms; the aryl or a heteroaryl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ), N-lower alkylamino carbonyl (C 1 -C 4 ); W represents (CH 2 ) p , where p represents 0 to 1; X represents an oxygen, sulphur, nitrogen or no atom; Y represents CHR 5 CO wherein R 5 represents hydrogen or methyl or (CH 2 ) q wherein q represents 0 to 4; Z represents oxygen, sulphur, NR 10 , wherein R 10 represents hydrogen, C 1-6 alkyl; Q represents (CH 2 ) n wherein n represents 0 to 4, or CHR 8 wherein R 8 represents H, OH, C 1-6 , alkyl, alkenyl alkoxy or CH 2 CHR 9 wherein R 9 represents H, OH, lower alkyl (C 1 -C 4 ) or lower alkoxy (C 1 -C 4 ); R 6 and R 7 are independently selected from COOH, H, CH 3 , CONH 2 , NH 2 , CH 2 NH 2 ; R 4 represents C 1 -C 15 saturated or unsaturated aliphatic hydrocarbon groups in which any 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen, arylalkyl, arylalkenyl, heteroarylalkyl or heteroarylalkenyl having 1 to 2 hetero atoms selected from a group consisting of nitrogen, oxygen and sulphur atoms with option that any 1 to 3 hydrogen atoms on the ring in said arylalkyl, arylalkenyl, hetero arylalkenyl group may be substituted with lower alkyl(C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxyl, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhaloalkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl(C 1 -C 4 ) amino, N-lower alkyl (C 1 -C 4 ) amino carbonyl.