Patent ID: 7608263

Claim:
A method for selectively destroying a cell expressing a human RG1 polypeptide having the amino acid sequence of SEQ ID NO: 2, which method comprises reacting an effective amount of an immunoconjugate with the cell wherein (i) the immunoconjugate comprises an isolated antibody or a fragment thereof that binds to RG1 polypeptide having the amino acid sequence of SEQ ID NO: 2, conjugated to a therapeutic agent, and (ii) the isolated antibody or a fragment thereof comprises a) a light chain variable region comprising the amino acid sequence of SEQ ID NO: 26 or SEQ ID NO: 29, or b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 30, or SEQ ID NO: 31 or c) a light chain variable region having the amino acid sequence of SEQ ID NO: 26 and a heavy chain variable region having the amino acid sequence of SEQ ID NO: 27 or SEQ ID NO: 28, or d) a light chain variable region having the amino acid sequence of SEQ ID NO: 29 and a heavy chain variable region having the amino acid sequence of SEQ ID NO: 30 or SEQ ID NO: 31, thereby selectively destroying the cells expressing human RG1 polypeptide having the amino acid sequence of SEQ ID NO: 2.