Patent ID: 8852626

Claim:
A method of treating an otic disease or condition comprising administering an intratympanic composition on or near the round window membrane of an individual in need thereof, the intratympanic composition comprising: between about 0.01% to about 20% by weight of a micronized Central Nervous System (CNS) modulator, or pharmaceutically acceptable salt thereof; and a polyoxyethylene-polyoxypropylene copolymer in an amount sufficient to provide a gelation temperature between about 19° C. to about 42° C., and a gelation viscosity between about 15,000 cP and about 1,000,000 cP; and the intratympanic composition having an osmolarity of less than about 1000 mOsm/L; wherein the intratympanic composition provides a sustained release of a therapeutically effective amount of the CNS modulator across the round window membrane into the cochlea for a period of at least 5 days after a single administration.