Patent ID: 8367102

Claim:
A method of treating a skin disorder, which comprises a step of orally administering to a mammal having the skin disorder, an oral pharmaceutical composition of isotretinoin, which comprises a semi-solid preparation containing at least two lipidic excipients, at least one of them being hydrophilic having a Hydrophobic Lipidic Balance (HLB) value equal to or greater than 10, the other being an oily vehicle, whereby the at least one hydrophilic lipidic excipient(s) with a HLB value of at least 10 is selected from the group consisting of glycerol macrogolglycerides; the composition being administered in an amount effective to treat the skin disorder, and wherein the skin disorder is selected from the group consisting of acne, hypertrophic lupus erythematosus, basal cell carcinoma and squamous cell carcinoma.