Patent ID: 7122551

Claim:
A compound of the formula I, or a pharmaceutically acceptable salt, or an in vivo hydrolysable ester thereof, wherein B is a 2-pyridyl or 2-pyridyloxy group monosubstituted at the 4-, 5-, or 6-position by trifluoromethyl; X is a carbon atom; R 1 is a trimethyl-1-hydantoin C 2-4 alkyl or a trimethyl-3-hydantoin C 2-4 alkyl group; or R 1 is phenyl or C 2-4 alkylphenyl monosubstituted at the 3- or 4-position by halogen, trifluoromethyl, C 1-3 alkyl, or C 1-3 alkoxy; or R 1 is phenyl-SO 2 NHC 2-4 alkyl; or R 1 is 2-pyridyl or 2-pyridyl C 2-4 alkyl; or R 1 is 3-pyridyl or 3-pyridyl C 2-4 alkyl; or R 1 is 2-pyrimidine-SCH 2 CH 2 ; or R 1 is 2- or 4-pyrimidinyl C 2-4 alkyl optionally monosubstituted by one of halogen, trifluoromethyl, C 1-3 alkyl, C 1-3 alkyloxy, 2-pyrazinyl optionally substituted by halogen, or 2-pyrazinylC 2-4 alkyl optionally substituted by halogen.