Patent ID: 8901118

Claim:
A compound having the chemical structure of Formula I, or a salt, a solvate, a tautomer or a stereoisomer thereof, wherein: X 1 is N; Y 1 is —N═ and R 3 is hydrogen; or Y 1 is —C(H)═ and R 3 is fluoro or chloro; L 1 is —C(H 2 )— or —C(O)—; Cy 1 is cycloalkyl optionally substituted with one or more R 4 , phenyl optionally substituted with one or more R 5 , or 5 or 6 membered heteroaryl optionally substituted on an available carbon atom with one or more R 6 and optionally substituted on an available nitrogen atom with R 7 ; R 2 is selected from the group consisting of hydrogen, cycloalkyl, lower alkyl optionally substituted with one or more R 8 , —N(R 9a )(R 9b ), and —O—R 9 ; each R 4 is independently selected from the group consisting of fluoro, —OH, lower alkyl optionally substituted with one or more fluoro, and lower alkoxy optionally substituted with one or more fluoro; each R 5 is independently selected from the group consisting of fluoro, chloro, —O—R 10 , —S—R 11 , —S(O 2 )—R 12 , and lower alkyl optionally substituted with one or more R 13 ; each R 6 is independently selected from the group consisting of fluoro, chloro, bromo, cycloalkyl, lower alkyl optionally substituted with one or more fluoro, and lower alkoxy optionally substituted with one or more fluoro; or two R 6 bound to adjacent carbon atoms of the heteroaryl ring form a fused cycloalkyl ring; R 7 is cycloalkyl, lower alkoxy or lower alkyl optionally substituted with one or more fluoro; R 8 is fluoro or lower alkoxy optionally substituted with one or more fluoro; R 9a is H and R 9b is selected from the group consisting of (i) H, lower alkyl, lower alkyl substituted with one or more fluoro, lower alkyl substituted with lower alkoxy or lower alkyl substituted with hydroxyl and (ii) cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, each of which is optionally substituted with one to three members selected from lower alkyl, haloalkyl, lower alkoxy or fluoro; or R 9a and R 9b together with the nitrogen to which they are attached form a 5- or 6-membered ring having from 0 to 1 additional heteroatom selected from O, N or S, each of which is optionally substituted with one to three members selected from lower alkyl, haloalkyl, lower alkoxy or fluoro; R 9 is lower alkyl, lower alkyl substituted with one or more fluoro, or lower alkyl substituted with lower alkoxy; each R 10 , R 11 and R 12 are independently lower alkyl optionally substituted with one or more fluoro; and each R 13 is independently selected from the group consisting of fluoro, —OH, and lower alkoxy optionally substituted with one or more fluoro.