Patent ID: 6894047

Claim:
A compound of formula I a stereoisomer thereof, a prodrug of said compound or stereoisomer, or a pharmaceutically acceptable salt of said compound, stereoisomer or prodrug; wherein R 1 is a) hydrogen or b) —C 1 -C 4 )alkyl; R 2 and R 3 are each independently a) hydrogen, b) —(C 1 -C 4 )alkyl, c) —(C 3 -C 6 )cyoloalkyl or d) phenyl which for each occurrence is optionally substituted with one or two substituants, each substituent is independently selected from Group Q; X is a) —C(O)—R 4 -Z, b) —SO 2 —R 4 -Z, c) —C(O)—NR 5 R 6 , d) —SO 2 —NR 5 R 6 or e) 1,3,5-triazin-2-yl having R z1 and R z2 substituents; R 4 is a) a covalent bond or b) —(C 1 -C 4 )alkyl-; Z is a) phenyl or benzyl wherein the phenyl ring in each of these groups is optionally substituted with one or two substitutents, each substituent is independently selected from Group Q, or b) Het; R 5 and R 6 are each independently a) hydrogen, b) —(C 1 -C 4 )alkyl or c) (C 3 -C 8 )cycloalkyl; or R 5 and R 6 are taken together along with the nitrogen atom to which they are attached to form pyrrolidinyl or piperidinyl; Het is a) pyridyl, b) thiazolyl, c) oxazolyl, d) quinolyl, e) isoqulnolyl, f) phthalizinyl, g) quinoxalyl, h) benzthlazolyl, i) benzoxazolyl, j) benzofuranyl, k) benzothinyl, l), furanopyridyl or m) thienopyridyl; wherein each of these groups is optionally substituted with one or two substituents, each substituent is independently selected from Group Q; Group Q is a) fluoro, b) chloro, c) bromo, d) —(C 1 -C 4 )alkyl, e) —(C 3 -G 6 )cycloalkyl, f) —O—(C 1 -C 4 )alkyl, g) —S—(C 1 -C 4 )alkyl, h) —SO 2 —(C 1 -C 4 )alkyl, i) hydroxy or j) —(C 1 -C 4 )alkyl-hydroxy; R z1 and R z2 are each independently selected from a) hydrogen, b) hydroxy, c) chloro, d) —(C 1 -C 4 )alkyl, e) —(C 3 -C 6 )cycloalkyl, f) —O—(C 1 -C 4 )alkyl, g) —(C 1 -C 4 )alkyl-O—(C 1 -C 4 )alkyl, h) —CHO, i) —C(O)—(C 1 -C 4 )alkyl, j) —(C 1 -C 6 )alkyl-hydroxy, k) phenyl which for each occurrence is optionally substituted with one or two substitutents, each substituent is independently selected from Group Q, l) pyrroyl, m) imidazolyl or n) triazolyl.