Patent ID: 7910133

Claim:
A suspension of microcapsules in an aqueous liquid phase, said suspension being intended for oral administration and allowing the modified release of amoxicillin, wherein said suspension comprises a plurality of microcapsules and an aqueous liquid phase, wherein the aqueous liquid phase is saturated or becomes saturated with active principle(s) on contact with the microcapsules, and wherein each microcapsule comprises (a) a core comprising amoxicillin and (b) a film coating that: (i) is applied to the core, (ii) controls the modified release of the amoxicillin in gastrointestinal tract fluids, and (iii) comprises: (1) at least one film-forming polymer (P1) insoluble in gastrointestinal tract fluids, present in an amount of 50 to 90% by dry weight based on the total weight of the coating composition, and wherein at least one of said at least one film-forming polymer (P1) is a water-insoluble cellulose derivative; (2) at least one nitrogen-containing polymer (P2) present in an amount of 2 to 25% by dry weight based on the total weight of the coating composition, and wherein at least one of said at least one nitrogen-containing polymer (P2) is selected from the group consisting of: polyacrylamide, poly-N-vinylamide, and poly-N-vinyllactam; and (3) at least one plasticizer present in an amount of 2 to 20% by dry weight based on the total weight of the coating composition, and wherein at least one of said at least one plasticizer is selected from the group consisting of: glycerol esters, phthalates, citrates, sebacates, cetyl alcohol esters, and castor oil; and wherein the in vitro release profile of the suspension of microcapsules in an aqueous liquid phase on day ten is similar to the release profile on day zero, as measured using a type II apparatus according to the European Pharmacopoeia 3rd edition, in a phosphate buffer medium of pH 6.8, at a temperature of 37° C.