Patent ID: 8008440

Claim:
A macrocyclic compound of formula I: and pharmaceutically acceptable salts thereof, wherein A 1 is where the nitrogen is bonded to T and the carbonyl is bonded to A 2 ; X is 0, 1 or 2; R 1 is selected from the group consisting of: wherein (P) indicates the point of attachment to CH; W 1 to W 16 are each independently hydrogen or a protecting group used for orthogonal protection in peptide synthesis; and X is selected from the group consisting of: A 2 is selected from the group consisting of prolinyl, 4-hydroxyprolinyl, 4-tert-butoxyprolinyl; and where the nitrogen is bonded to the carbonyl of A 1 and the carbonyl is bonded to A 3 ; wherein y is 0, 1 or 2; R 2 is selected from the group consisting of: wherein (P) indicates the point of attachment to CH; and W 1 to W 16 are each independently hydrogen or a protecting group used for orthogonal protection in peptide synthesis; A 3 is selected from the group consisting of prolinyl, 4-hydroxyprolinyl, 4-tert-butoxyprolinyl; and where the nitrogen is bonded to the carbonyl of A 2 and the carbonyl is bonded to T; wherein z is 0, 1 or 2; R 3 is selected from the group consisting of: wherein (P) indicates the point of attachment to CH; and W 1 to W 16 are each independently hydrogen or a protecting group used for orthogonal protection in peptide synthesis; and (T) is selected from the group consisting of: wherein (A 3 ) indicates the site of a covalent bond to A 3 of formula I and (A 1 ) indicates the site of a covalent bond to A 1 of formula I; M is selected from the group consisting of —O—, —S—, —NH—, and —N(CH 3 )—; R 10 and R 11 are independently —H or —CH 3 ; and n1, n2, n3, n4, n5, n6 and n7 are independently 1 or 2; with the proviso that compounds wherein R 1 is —(CH 2 ) 3 —NW 3 —C(═NW 2 )—NHW 1 , R 2 is —H and R 3 is —CH 2 CO 2 W 5 are excluded.