Patent ID: 7375112

Claim:
A method of treating hypertriglyceridemia comprising administering a therapeutically effective amount for treating hypertriglyceridemia of a compound selected from the group consisting of pyridoxal, pyridoxal-5′-phosphate, pyridoxamine, a 3-acylated analogue of pyridoxal, a 3-acylated analogue of pyridoxal-4,5-aminal, a pharmaceutically acceptable salt thereof, and a mixture thereof to a patient in need thereof; a) wherein the 3-acylated analogue of pyridoxal comprises: wherein R 1 is alkyl, alkenyl, in which alkyl or alkenyl can be interrupted by nitrogen, oxygen, or sulfur, and can be unsubstituted or substituted at the terminal carbon by hydroxy, alkoxy, alkanoyloxy, alkanoyloxyaryl, alkoxyalkanoyl, alkoxycarbonyl, or dialkylcarbamoyloxy; alkoxy; dialkylamino; alkanoyloxy; alkanoyloxyaryl; alkoxyalkanoyl; alkoxycarbonyl; dialkylcarbamoyloxy; aryl, in which aryl can be substituted by alkyl, alkoxy, amino, hydroxy, halo, nitro, or alkanoyloxy; aryloxy; arylthio; or aralkyl; and b) wherein the 3-acylated analogue of pyridoxal-4,5-aminal comprises: wherein R 1 is alkyl, alkenyl, in which alkyl or alkenyl can be interrupted by nitrogen, oxygen, or sulfur, and can be unsubstituted or substituted at the terminal carbon by hydroxy, alkoxy, alkanoyloxy, alkanoyloxyaryl, alkoxyalkanoyl, alkoxycarbonyl, or dialkylcarbamoyloxy; alkoxy; dialkylamino; alkanoyloxy; alkanoyloxyaryl; alkoxyalkanoyl; alkoxycarbonyl; dialkylcarbamoyloxy; aryl, in which aryl can be substituted by alkyl, alkoxy, amino, hydroxy, halo, nitro, or alkanoyloxy; aryloxy; arylthio; or aralkyl; and R 2 is of the formula wherein R 3 and R 4 are each independently alkyl, alkenyl, cycloalkyl, aryl, or, when R 3 and R 4 are taken together to form a ring with the nitrogen atom, which may optionally be interrupted by a heteroatom, or a pharmaceutically acceptable acid addition salt thereof.