Patent ID: 7807138

Claim:
A method of determining the efficacy of clofibrate on a subject, the method comprising: analyzing a biological sample from the subject to determine the level(s) of one or more biomarkers for efficacy selected from the group consisting of glycine, 1-alanine, L-aspartic acid, palmitate, stearate, linoleic acid, arachidonic acid, docosahexanoic acid, lactic acid, succinic acid, malate, glycerol-1(3)-phosphate, 1-mono palmitoylglycerol, 1-mono stearoylglycerol, 2-monostearoylglycerol, 1-mono oleoylglycerol, 2-mono oleoylglycerol, 1-mono linoleoylglycerol, β-sitosterol, 2-(4-chlorophenoxy)-2-methyl-propanoic acid, and combinations thereof; comparing the level(s) of the one or more biomarkers in the sample to levels of the one or more biomarkers from a control sample exposed to efficacious level(s) of clofibrate; and determining whether clofibrate is efficacious in a subject.