Patent ID: 8586070

Claim:
A composition for treating bone and/or cartilage defects, wherein said composition is prepared by a method comprising the following steps: contacting a mammalian recombinant collagen with a peptidase or protease, wherein the mammalian collagen is of human, bovine, porcine, or equine origin and has at least one of an osteo-inductive activity or a chondro-inductive activity, and is filter sterilized; adding at least one scaffold material, wherein the scaffold material has osteo-conductive properties and is selected from the group of ceramic materials, biologically compatible metals, biologically compatible polymers and extracts of native bone, and mixing with the collagen; adding at least one differentiation or growth factor having osteo-stimulative and/or chondro-stimulative activity, and; co-lyophilizing the components to obtain an at least partly form-stable, spongy body, wherein the method is performed under aseptic conditions, thereby aseptically manufacturing the composition.