Patent ID: 7901881

Claim:
A method for classifying a thyroid lesion in a subject as benign or malignant comprising: a) measuring the expression of differentially expressed thyroid (DET) gene C21orf4, Hs.145049, Hs.296031, KIT, SYNGR2, C11orf8, CDH1, FAM13A1, IMPACT, and KIAA1128, in a test cell population obtained from the thyroid lesion in the subject; b) comparing the expression of said DET genes in the test cell population to the expression of said DET genes in normal thyroid tissue thereby creating an expression ratio pattern for the test cell population; and c) using Principal Component Analysis to compare the expression ratio-based pattern in the test cell population to the expression ratio-based pattern of cells from a benign thyroid lesion and cells from a malignant thyroid lesion, thereby classifying the thyroid lesion in the subject as benign or malignant.