Patent ID: 7932037

Claim:
A method of assaying a DNA sample comprising: providing a first encoded particle set comprising encoded particles having attached amplicons, the amplicons obtained by degenerate oligonucleotide primed PCR and the amplicons comprising random nucleic acid sequences together representing substantially an entire first template DNA sequence; hybridizing the amplicons of the first encoded particle set with detectably labeled sample DNA; hybridizing the amplicons of the first encoded particle set with detectably labeled reference DNA; detecting a first signal indicating specific hybridization of the amplicons of the first encoded particle set with delectably labeled sample DNA and a second signal indicating specific hybridization of the amplicons of the first encoded particle set with detectably labeled reference DNA; and comparing the first signal and the second signal to detect differences between the first and second signals, the differences of the first and second signals indicative of differences between the sample DNA and the reference DNA, thereby assaying the DNA sample.