Patent ID: 7045676

Claim:
A method of producing a recombinant protein comprising the steps of: (a) inserting into an embryo of a nonhuman mammal a DNA construct comprising a gene encoding said protein, said gene being under transcriptional control of a milk protein promoter sequence that does not naturally control transcription of said gene, said DNA construct further comprising a DNA sequence encoding a signal peptide for enabling secretion of said protein into the milk of said mammal, (b) transferring the embryo to a female mammal of the same species, (c) allowing said embryo to develop into an adult nonhuman mammal whose genome comprises said DNA construct, (d) inducing lactation in said mammal or transgenic progeny of said mammal, wherein the progeny's genome comprises said DNA construct, (e) collecting milk from said lactating mammal or lactating progeny, and (f) isolating said protein from said collected milk.