Patent ID: 7205103

Claim:
A method to identify a compound that modulates chromatin remodeling of a specific DNA sequence within chromatin comprising: a) providing chromatin assembled DNA containing a specific DNA sequence, which specific DNA sequence comprises a binding site for a zinc finger DNA binding domain of a nucleic acid regulatory protein, which zinc finger DNA binding domain interacts directly with a SWI/SNF chromatin remodeling complex comprising BRG1; b) contacting the chromatin assembled DNA with: 1) the SWI/SNF chromatin remodeling complex comprising BRG1, and 2) the nucleic acid regulatory protein zinc finger DNA binding domain alone; under conditions that permit the direct interaction of the SWI/SNF chromatin remodeling complex and the zinc finger DNA binding down; and c) determining the level of chromatin remodeling in the presence and absence of a test compound; wherein a difference in the level of chromatin remodeling in the presence and absence of the test compound identifies the test compound as a compound that modulates chromatin remodeling of the specific DNA sequence within chromatin.