Patent ID: 7790752

Claim:
A compound of formula (I): wherein R 1 is H, C 1-6 -alkyl, aryl, 5 or 6 membered heteroaryl or sulfonylaryl, each of which is optionally substituted by one or more B, —(CH 2 ) m —R a wherein R a is: CN, OR i , NR i R ii , or C 3-6 -cycloalkyl, 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl, each of which is optionally substituted by one or more B, or —(CH 2 ) n —(CO)—R b or —(CH 2 ) n —(SO 2 )—R b , wherein R b is: C 1-6 -alkyl, C 1-6 -alkoxy, C 3-6 -cycloalkyl, —(CH 2 ) m —NR iii R iv , NR i R ii , or C 3-6 -cycloalkyl, 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl, each of which is optionally substituted by one or more B, or R 1 and R 3 together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which is optionally substituted by ═O; there is one or more R 2 , wherein each R 2 is the same or different, R 2 is one or more H, OH, halo, CN, nitro, C 1-6 -alkyl optionally substituted by —NR iii R iv , C 1-6 -alkoxy, —O—CH 2 —C 2-6 -alkenyl, or benzyloxy, or two R 2 together with the indole ring to which they are attached form an oxo or dioxo bridge; R 3 is H, halo, or —(CO)—R c , wherein R c is: C 1-6 -alkyl, —(CH 2 ) n —NR i R ii , —(CH 2 ) n —NR iii R iv , or 5 or 6 membered heterocycloalkyl optionally substituted by C 1-6 -alkyl, or C 1-6 -alkyl or aryl, each of which is optionally substituted by halo, —O(CO)—C 1-6 -alkyl, or —NH(CO)R d , wherein R d is C 1-6 -alkyl optionally substituted by halo or nitro, or R d is aryl or a 5 or 6 membered heteroaryl, each of which is optionally substituted by halo, nitro, C 1-6 -alkyl or C 1-6 -haloalkyl; B is halo, CN, NR i R ii , C 1-6 -alkyl optionally substituted by CN, halo or C 1-6 -alkoxy, C 1-6 -alkoxy, C 1-6 -haloalkoxy, C 3-6 -cycloalkyl, —C(O)O—C 1-6 -alkyl, —C(O)NR i R ii , —C(O)—C 1-6 -alkyl, —S(O) 2 —C 1-6 -alkyl, —S(O) 2 —NR i R ii , or (CR iii R iv ) n -phenyl or (CR iii R iv ) n -5 or 6 membered heteroaryl, wherein the phenyl or 5 or 6 membered heteroaryl moiety is optionally substituted by one or more substituent(s) selected from the group consisting of halo, CN, NR i R ii , C 1-6 -alkyl optionally substituted by CN or C 1-6 -alkoxy, C 1-6 -alkoxy, C 1-6 -haloalkoxy, C 3-6 -cycloalkyl, —C(O)O—C 1-6 -alkyl, —C(O)—NR i R ii , —C(O)—C 1-6 -alkyl, —S(O) 2 —C 1-6 -alkyl, and —S(O) 2 —NR i R ii ; R i and R ii are each independently H, C 1-6 -alkyl, C 1-6 -alkyl-NR iii R iv , —(CO)O—C 1-6 -alkyl, —C(O)—NR iii R iv , —C(O)—C 1-6 -alkyl, —S(O) 2 —C 1-6 -alkyl or —S(O) 2 —NR iii R iv ; R iii and R iv are each independently H or C 1-6 -alkyl; m is 1 to 6; n is 0 to 4; and A is either a group of the formula (a) or (b): wherein R 4 is H or C 1-6 -alkyl; and R 5 is aryl optionally substituted by halo; or a pharmaceutically acceptable salt thereof.