Patent ID: 8097698

Claim:
A glucagon-like peptide 1 (GLP-1) derivative, said derivative containing a single lipophilic substituent of from 8 to 40 carbon atoms attached, optionally via a spacer, to the C-terminal amino acid residue of a parent polypeptide where i) the parent polypeptide is selected from the group consisting of GLP-1 (7-35), GLP-1 (7-36), GLP-1 (7-37), GLP-1 (7-38), GLP-1 (7-39), GLP-1 (7-40), GLP-1 (7-41) and an analogue of any of GLP-1 (7-35), GLP-1 (7-36), GLP-1 (7-37), GLP-1 (7-38), GLP-1 (7-39), GLP-1 (7-40) and GLP-1 (7-41) where the total number of different amino acids between said analogue and the corresponding native form of GLP-1 does not exceed five, and ii) the lipophilic substituent is selected from the group consisting of an acyl group of a straight-chain alkane α,ω-dicarboxylic acid, an acyl group of an alkyl group, and a straight chain alkyl group.