Patent ID: 7320987

Claim:
A method for treating rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohns disease, irritable bowel syndrome, inflammatory bowel disease, psoriasis, adult respiratory distress syndrome, asthma, or chronic obstructive pulmonary disease, comprising: administering to a patient in need of such treatment, an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: Z is CH: X 1 is O, NR 4 (where R 4 is hydrogen or alkyl), S or C═O: R 1 is alkyl, cycloalkyl, cycloalkylalkyl or —CH 2 -alkenyl: R 2 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, alkylene-C(O)—R 21 (where R 21 is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), amino, monoalkylamino, dialkylamino, acyl, or NR 22 —Y—R 23 (where Y is —C(O), —C(O)O—, —C(O)NR 24 , S(O) 2 or S(O) 2 NR 25 ; R 22 , R 24 and R 25 are independently hydrogen or alkyl; and R 23 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or optionally-substituted phenyl); and R 3 is alkyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl, cyanoalkyl, heterocyclyl, heterocyclylalkyl, or -heterocycloamino-SO 2 —R 12 (where R 12 is haloalkyl, aryl, aryalkyl, heteroaryl or heteroaralkyl).