Patent ID: 8840894

Claim:
An isolated human antibody or antigen-binding fragment thereof that specifically binds to, or blocks the biological activity of wild-type mature human GDF8 comprising SEQ ID NO: 340, but (a) does not bind to, or block the biological activity of a chimeric GDF8/TGFβ1 construct having amino acids 48-72 of mature human GDF8 replaced with the corresponding amino acid sequence of TGFβ1, and (b) does not bind to an isolated polypeptide consisting of amino acids 48-72 of SEQ ID NO: 340; and wherein the antibody or antigen-binding fragment comprises a heavy and light chain variable domain amino acid sequence pair (HCVR/LCVR) selected from the group consisting of SEQ ID NOs: 114/122; 360/368; and 376/384.