Patent ID: 8394365

Claim:
A composition comprising a multi-arm polymer prodrug having the structure: R(-Q-POLY 1 -X′-D 0,1 ) q I wherein R is an organic radical possessing from 3 to 25 carbon atoms, Q is a linker, wherein R, when taken together with Q, is a residue of a polyol or a polythiol after removal of “q” hydroxyl or thiol protons, respectively, to form a point of attachment for POLY 1 , POLY 1 is a water-soluble and non-peptidic polymer selected from the group consisting of poly(alkylene glycol), poly(olefinic alcohol), poly(vinylpyrrolidone), poly(hydroxylalkylmethacrylamide), poly(hydroxyalkyl-methacrylate), poly(α-hydroxy acid), poly(acrylic acid), poly(vinyl alcohol), polyphosphazene, polyoxazoline, poly(N-acryloylmorpholine), and copolymers or terpolymers thereof, X is a spacer corresponding to —CH 2 C(O)NHCH 2 C(O)O—, X′ is either (i) the spacer, X, or is (ii) X″, a terminal moiety, D is a camptothecin attached at its 10-, 11- or 20-ring position, where D 1 indicates the presence of D and D 0 indicates its absence, q has a value from 3 to 25, wherein if X′ is X, then D is D 1 , and if X′ is X″, then D is D 0 , and X′ is X in one or more of “q” polymer arms.