Patent ID: 7129235

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein A is X 1 is N or CR 1 ; X 2 is N or CR 2 ; X 3 is S, O or N; R is absent or O; R 1 is hydrogen, lower alkoxy, lower alkenyl, lower alkyl, lower alkylthio, lower alkynyl, lower haloalkoxy, lower haloalkyl, lower haloalkylthio, halogen, hydroxy, mercapto, nitro, R A R B NS(O) 2 — or R A R B N—; R 2 , R 3 , and R 4 are independently hydrogen or halogen; R 7 is hydrogen, alkenyl, alkoxy, alkoxycarbonyl, alkoxysulfonyl, alkyl, alkylcarbonyl, alkoxycarbonylalkyl, alkylsulfonyl, alkylthio, alkynyl, aryl, arylalkyl, aryloxy, arylthio, cyanoalkyl, cycloalkyl, cycloalkylalkyl, cycloalkyloxy, cycloalkylthio, haloalkoxy, haloalkyl, haloalkylsulfonyl, haloalkylthio, halogen, heteroaryl, heteroarylalkyl, heteroaryloxy, heteroarylthio, heterocycle, heterocyclealkyl, hydroxy, hydroxyalkyl, —R C R D N—, (R A R B N)carbonyl-, (R A R B N)sulfonyl- ; or R A S(O) 2— ; R 6 and R 8 are independently hydrogen, lower alkenyl, lower alkoxy, lower alkyl, lower alkylthio, lower alkynyl, lower haloalkoxy, lower haloalkyl, lower haloalkylthio, halogen, hydroxy, mercapto, or R A R B N—; alternatively, R 7 and R 6 taken together with the atoms they are attached can form a ring selected from the group consisting of 2,2,3,3-tetrafluoro-2,3-dihydro-benzo[1,4]dioxinyl; 2,3-tetrahydro-benzo[1,4]dioxinyl; 2,2-difluoro-benzo[1,3]dioxolyl; and 2,2-dihydro-benzo[1,3]dioxolyl; R A and R B are independently alkyl, hydrogen, haloalkyl, or heterocycle; R C and R D are independently hydrogen, alkenyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkynyl, or (NR A R B )carbonyl; L is — is absent or a single bond; and R 11 , R 12 , R 13 , and R 14 are independently hydrogen, alkoxy, alkyl, or hydroxy.