Patent ID: 6887670

Claim:
A method for determining the presence of a human adenine nucleotide translocator (ANT) polypeptide in a biological sample comprising: contacting a biological sample suspected of containing a human ANT polypeptide with an ANT ligand under conditions and for a time sufficient to allow binding of the ANT ligand to a human ANT polypeptide; and detecting the binding of the ANT ligand to a human ANT polypeptide, and therefrom determining the presence of the human ANT polypeptide in said biological sample, wherein the ANT ligand comprises an atractyloside derivative having the following structure: and stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 is halogen, â€”OC(â•O)R 4 or â€”NHR 4 ; R 2 is hydrogen or â€”C(â•O)R 5 ; R 3 is â€”CH 3 or â•CH 2 ; R 4 is â€”X-arylalkyl, â€”X-substituted arylalkyl, X-heteroaryl, or â€”Xâ€”heteroarylalkyl, wherein X is an optional amido or alkylamido linker moiety and R 5 is alkyl.