Patent ID: 8481780

Claim:
A method of preparing bromfenac sodium Form I, comprising crystallizing or recrystallizing bromfenac sodium a solvent mixture comprising water, at least one dialkoxyalkane, and at least one anti-solvent, wherein the bromfenac sodium Form I is characterized by at least one of the following: (a) a powder x-ray diffraction pattern having main peaks expressed as 2-theta at about 4.4, 8.8, 9.4, 12.1, 15.2, 15.9, 17.6, 18.2, 18.8, 20.2, 21.2, 24.7, 28.4, and 32.4 degrees and substantially free of any other physical forms of bromfenac sodium; (b) a powder x-ray diffraction pattern in accordance with that shown in FIG. 1 and substantially free of any other physical forms of bromfenac sodium; (c) an XRPD d-spacing/% intensity pattern in accordance with that shown in Table A and substantially free of any other physical forms of bromfenac sodium; and (d) an FT-IR spectrum in accordance with FIG. 2 and substantially free of any other physical forms of bromfenac sodium.