Patent ID: 7534881

Claim:
A method for preparing a compound of formula II, wherein: R 1 and R 3 are each independently hydrogen, halogen, cyano, nitro, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, aryl or substituted aryl, OR a , SR a , S(═O)R e , S(═O) 2 R e , P(═O) 2 R e , S(═O) 2 OR e , P(═O) 2 OR e , NR b R c , NR b S(═O) 2 R e , NR b P(═O) 2 R e , S(═O) 2 NR b R c , P(═O) 2 NR b R c , C(═O)OR e , C(═O)R a , C(═O)NR b R c , OC(═O)R a , OC(═O)NR b R c , NR b C(═O)OR e , NR d C(═O)NR b R c , NR d S(═O) 2 NR b R c , NR d P(═O) 2 NR b R c , NR b C(═O)R a , or NR b P(═O) 2 R e ; X is —O—, —OC(═O)—, —S—, —S(═O)—, —S(═O) 2 —, —C(═O)—, —C(═O)O—, —NR d —, —NR d C(═O)—, —C(═O)NR d —, —NR d C(═O)NR d —, —NR d C(═O)O—, —OC(═O)NR d —, —NR d S(═O) 2 —, —N d S(═O) 2 NR d —, —S(═O) 2 NR d —, halogen, nitro, cyano, or a bond; R 2 is selected from: a) hydrogen, provided that R 2 is not hydrogen if X is —S(═O)—, —SO 2 —, —OC(═O)—, —OC(═O)NR d —, or —S(═O) 2 NR d —; b) alkyl or substituted alkyl, alkenyl or substituted alkenyl, and alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl; and c) heterocycle or substituted heterocycle, aryl or substituted aryl; except that R 2 is absent if X is halogen, nitro, or cyano; R 1 and R 2 together may optionally form a 3-7 membered optionally substituted carbocyclic ring or 3-7 membered optionally substituted heterocyclic ring; D is CHO, CN, C(═O)R a , C(═O)OR e , or C(═O)NR b R c ; R a is hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, or aryl or substituted aryl; R b , R c and R d are each independently hydrogen, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, heterocycle or substituted heterocycle, or aryl or substituted aryl, or said R b and R c together with the N to which they are bonded optionally form a heterocycle or substituted heterocycle; R e is alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, or aryl or substituted aryl; comprising: reacting a compound of formula I, with a benzoyl hydroxyl amine of formula III, wherein R 4 is nitro, cyano, halogen, OMe, or OEt, and n is 1, 2, or 3; in the presence of a base to form the compound of formula II.