Patent ID: 7659245

Claim:
A compound of the formula I: and N-oxides, salts, and stereoisomers thereof wherein A is OR 1 , NHS(═O) p R 2 ; wherein; R 1 is hydrogen, C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl; R 2 is C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; denotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C 1 -C 6 alkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxyl, halo, haloC 1 -C 6 alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C 1 -C 6 alkylcarbonylamino, C 0 -C 3 alkylenecarbocyclyl and C 0 -C 3 alkyleneheterocyclyl; R 5 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; and wherein each C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocycyl or C 0 -C 3 alkyleneheterocyclyl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, oxo, nitrile, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl, NH 2 C(═O)—, Y—NRaRb, Y—O—Rb, Y—C(═O)Rb, Y—(C═O)NRaRb, Y—NRaC(═O)Rb, Y—NHS(═O p )Rb, Y—S(═O) p Rb and Y—S(═O) p NRaRb, Y—C(═O)ORb, Y—NRaC(═O)ORb; Y is independently a bond or C 1 -C 3 alkylene; Ra is independently H, C 1 -C 6 alkoxy, C 1 -C 3 alkyl or; Rb is independently H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 0 -C 3 alkylenecarbocyclyl or C 0 -C 3 alkyleneheterocyclyl; or Ra and Rb together with the nitrogen to which they are attached join to form a heterocyclyl group.