Patent ID: 7601361

Claim:
A medical device having a durable antimicrobial polymeric surface, said surface comprising a chemically modified polymer substrate selected from the group consisting of polyamides, polyurethanes and polyureas and at least one linear cationic antimicrobial peptide having a net positive charge of greater than 1 at physiological pH, wherein said peptide is selected from the group consisting of: PKGLKKLLKGLKKLLKL (SEQ ID NO: 1); KGLKKLLKGLKKLLKL (SEQ ID NO: 2); KGLKKLLKLLKKLLKL (SEQ ID NO: 3); LKKLLKLLKKLLKL (SEQ ID NO: 4); and LKKLLKLLKKLL (SEQ ID NO: 5); and wherein said chemically modified surface is provided by a treating a polymer substrate with a first fluid comprising formaldehyde and a co-reactant selected from the group consisting of acid, anhydride, reactive halide, and mixtures thereof; wherein the formaldehyde and co-reactant are present in amounts effective to provide a polymer substrate with a chemically modified surface and wherein said peptide is bonded to the chemically modified polymer substrate.