Patent ID: 7056903

Claim:
A compound of the Formula I: wherein: R 1 and R 3 each independently is optionally substituted aryl; R 2 is phenyl optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythlo, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, arylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfnylamino, alkylsulfnylamino and trifluoromethyl; R 4 is —COOH or tetrazolyl; A is a single bond, —O(CH 2 ) p —, —S(CH 2 ) p —, —NR′(CH 2 ) p —, —(CH 2 ) p O—, —O(CH 2 ) p O—,—(CH 2 ) p O(CH 2 ) n CO(CH 2 ) n —, —CON—, —NCO—; —(CH 2 ) p —, —C═C—, or —C═C— B is —(CH 2 ) q ; m, p, and q are each independently in each occurrence an integer from 1 to 3 inclusive; n and r are each 0; wherein each aryl is independently phenyl, naphthyl or indanyl, and is optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, alkylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfonylamino, arylsulfonylamino and trifluoromethyl; and or an individual isomer, a racemic or non-racemic mixture of isomers, or a pharmaceutically acceptable salt or solvate thereof.