Patent ID: 7829063

Claim:
A compound consisting of the Formula Ia or Ib: wherein for Ia and Ib: each G is independently a bond or is independently selected from the group consisting of cycloalkyl, aryl-CH(Y)—, heterocyclyl, aryl and heteroaryl, wherein said cycloalkyl, aryl-CH(Y)—, heterocyclyl, aryl and heteroaryl are substituted or unsubstituted; n is 0, 1, 2 or 3; X is a bond, or is selected from the group consisting of —O—, —S—, —S(O)—, —S(O) 2 —, —NR o — where R o is H, C 1-5 alkyl or CH 2 CO 2 R″ wherein R″═H or C 1 -C 3 -alkyl; —NR o —C(O)—CH(R)— where R o is H or C 1-5 alkyl; heterocyclyl, aryl, heteroaryl, C 1-6 alkyl and C 1-6 alkyl wherein 1 or 2 carbon atoms of the C 1-6 alkyl is replaced by a —O—, —C(O)—, —S—, —S(O)—, —S(O) 2 — or —NR′″— where R′″ is H or C 1-5 alkyl, and where the C 1-6 alkyl is optionally substituted with 1 or 2 substituents selected from the group consisting of —OH, —SH, NH 2 , heterocyclyl, aryl and heteroaryl; X′ is selected from the group consisting of a quaternary ammonium salt, imidate salt, thiolate salt, oxonium cation, boron-amine salt, pyridinium salt, —SO 2 H, —SO 3 H, —PO 3 H, —OPO 3 H, N-oxide, —B(OH) 2 , —OH, amino, halo, —CF 3 , —CH 2 F, —CHF 2 , —COOH, —COOC 1-5 alkyl, —COC 1-5 alkyl, —CO-aryl, —CO-heteroaryl, C 1-6 alkyl, amino-C 1-5 alkyl-, optionally substituted aryl, optionally substituted heteroaryl, halo-C 1-5 alkyl, halo-C 1-5 alkoxy; Z′—C 1-6 alkyl, Z′—C 2-6 alkyl-O—, Z′-C 2-6 alkyl-O-C 1-3 alkyl-, Z′—C 2-6 alkyl-S—, Z′—C 2-6 alkyl-NH—, Z′—C 2-6 alkyl-NH—C 1-3 alkyl-, Z′—C 2-6 alkyl-N(C 1-3 alkyl)-C 1-3 alkyl-, Z′—(CH 2 CH 2 —O) 1-5 —, wherein Z′ is selected from the group consisting of halo, —CF 3 , —CH 2 F, —CHF 2 , aryl, substituted aryl, heteroaryl, and substituted heteroaryl; Y is H or is selected from the group consisting of a quaternary ammonium salt, imidate salt, thiolate salt, oxonium cation, boron-amine salt, pyridinium salt, —SO 2 H, N-oxide, —B(OH) 2 , —COOR″, —SO 3 R″, —P(O) 2 OR″ and —OP(O) 2 OR″ wherein R″ is H or C 1-3 alkyl; R is H or a side chain of an encoded amino acid, halobenzyl, —C 1-5 alkyl-OR″-C 1-5 alkyl-N(R″) 2 , —C 1-5 alkyl-NR″C(O)—(CH 2 CH 2 O) m —C 1 -C 5 -alkyl-CO 2 R″ wherein m is 0-8, —C 1-5 alkyl-NR″C(O)—C 1 -C 5 -alkyl-X′ wherein said —C 1-5 alkyl is optionally substituted with OR″ or CH 2 OR″, —C 1-5 alkyl-o, m, or p-aryl-(O—CH 2 CH 2 ) 1-5 -halo wherein said —(O—CH 2 CH 2 ) 1-5 -halo is optionally substituted with one or more OR″, or —C 1-5 alkyl-o, m, or p-aryl-(CH 2 CH 2 ) 1-5 -halo, wherein R″═H or C 1 -C 3 -alkyl; and Z is —CH 2 O—; wherein at least one of the group X, X′, G, X and Y optionally comprises a radionuclide; or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixtures of stereoisomers thereof.