Patent ID: 7449457

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein A 3 , A 4 , A 5 and A 6 , together with the two carbons to which they are attached, complete a substituted benzene in which A 3 is CR 3 , A 4 is CR 4 , A 5 is CR 5 , and A 6 is CR 6 ; wherein each of R 3 , R 4 and R 6 is hydrogen; and R 5 is fluoro or chloro; R 1 is 2-pyridinyl which bears a fluoro or chloro substituent at the 5-position; X 2 is N and each of X 3 , X 5 and X 6 is CH; or X 3 is N and each of X 2 , X 5 and X 6 is CH; and R 2 is —NR s R t in which R s is hydrogen and R t is hexahydro-2-oxoazepin-3-yl or 1-azabicyclo[2.2.2]oct-3-yl, or —NR s R t is pyrrolidin-1yl, 3-aminopyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl, 3-aminocarbonylpiperidin-1-yl, 3-hydroxypiperidin-1-yl, 3-hydroxymethylpiperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, 4-methylpiperazin-1-yl, 4-isopropylpiperazin-1-yl, 4-formyl-piperazin-1-yl, 4-(2-hydroxyethyl)piperazin-1-yl, or 3-oxopiperazin-1-yl.