Patent ID: 7388014

Claim:
A method for treating tumors comprising administering a composition comprising a compound of the formula: wherein: n=1 or 2; when n=1, (R 1 ) 1 is selected from 6-NHCH 2 R 3 , H, 6-nitro, 6-bromo, 6-iodo, 7-fluoro, and 5-methyl; when n=2, (R 1 ) 2 is selected from 6,7-dimethoxy, 6,7-diethoxy, and imidazol[4,5-g]-; and wherein R 3 is selected from the group consisting of —CH(CH 3 ) 2 , and Ar, where Ar is selected from (a) 4-substituted phenyl, wherein the 4-substituent is selected from —CH(CH 3 ) 2 , —OCH 2 Ph, —OCH 2 CH 2 CH 3 , and -Ph; (b) 3-substituted phenyl, wherein the 3-substituent is selected from methoxy, 4-chlorophenoxy, benzyloxy, 4-methoxyphenoxy, 4-methylphenoxy, 3-trifluoromethylphenoxy and methyl; (c) 2-substituted phenyl, wherein the 2-substituent is selected from methyl, nitro, and benzyloxy; (d) disubstituted phenyl selected from 2,4-dimethoxyphenyl, 2,6-dimethoxyphenyl, 2,5-dimethoxyphenyl, 3,5-dimethoxyphenyl, 2,5-dimethylphenyl, and 4,4-ethylenedioxy; (e) pyridine-3-yl; and (f) naphthylen-1-yl, optionally substituted with methoxy in the 2-position; and (i) when (R 1 ) 1 is 6-NHCH 2 R 3 , then R 2 is selected from 3-bromophenyl, 3-chloro-4-fluorphenyl, and (ii) when (R 1 ) 1 is H, 6-nitro, 6-bromo, 6-iodo, 7-fluoro, or 5-methyl, then R 2 is selected from (a) cyclohexyl; (b) a substituted phenyl, selected from 2,4,6-trimethylphenyl, 2-fluoro-4-chlorophenyl, 4-fluorophenyl, and 2-chlorophenyl; (c) CH 2 Ar, wherein Ar is selected from naphthylen-1-yl; 2-trifluoromethylphenyl, and 3-trifluoromethylphenyl; (d) (CH 2 ) 2 Ar, wherein Ar is selected from phenyl, 3-fluorophenyl, and 4-fluorophenyl; (e) α-methylbenzyl; and (f) 4-phenylbutyl; (iii) when (R 1 ) 2 is 6,7-dimethoxy, then R 2 is selected from (a) (CH 2 ) m Ar, wherein, m is 1, 2 or 4 and, when m=1, Ar is selected from 2-chlorophenyl, 4-chlorophenyl, 2-fluorophenyl, 2-chloro-6-fluorophenyl, and 3-trifluoromethylphenyl; when m=2 then Ar is selected from phenyl and 3-fluorophenyl and when m=4, Ar is phenyl; and (b) α-methylbenzyl; (iv) when (R 1 ) 2 is 6,7-diethoxy, then R 2 is selected from (a) (CH 2 ) m Ar, wherein, m is 1, 2 or 4 and, when m=1, Ar is selected from 2-chlorophenyl, 4-chlorophenyl, 2-fluorophenyl, 2-chloro-6-fluorophenyl, 3-trifluoromethylphenyl, and 3,5-dimethoxyphenyl; when m=2 then Ar is selected from phenyl and 3-fluorophenyl and when m=4, Ar is phenyl; and (b) α-methylbenzyl; and (v) when (R 1 ) 2 is imidazol[4,5-g]-, then R 2 is selected from (a) isopropyl; (b) phenyl, optionally substituted in the 2-position with a methyl group or in the 4-position with a substituent selected from methoxy, ethyl, isopropyl, and n-butyl; (c) 2,4,6,-trimethyl phenyl; (d) CH 2 Ar, wherein Ar is selected from 3-fluorophenyl and 2,5-difluorophenyl; (e) (CH 2 ) m Ar, wherein m is 2 or 4 and, when m=2, Ar is selected from phenyl, 3-fluorophenyl, 4-methylphenyl and when m=4, Ar is phenyl; and (f) α-methylbenzyl or a pharmaceutically acceptable salt thereof to a subject in need of such treatment, thereby treating the tumor.