Patent ID: 7524855

Claim:
A compound of Formula I, wherein R 1 represents wherein R 5 is cyano, carboxylic acid or the group wherein R 9 represents hydrogen, lower alkyloxy, lower alkylamino, lower alkyl with 1 to 6 carbon atoms, aminocarbonylalkyl, mono- or dialkylaminoalkyl, alkyloxyalkyl, arylalkyl, aryl, or heteroaryl, wherein the aryl and heteroaryl groups can be optionally mono-, di-, or tri-substituted with straight or branched chain lower alkyl with 1 to 4 carbon atoms, wherein these substituents may be the same or different; R 10 represents hydrogen, or lower alkyl with 1 to 4 carbon atoms; or R 9 and R 10 together with the nitrogen atom to which they are attached, form a 3-, 4-, 5- or 6- membered heterocyclic ring, wherein the 5- or 6-membered ring optionally contains an additional heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, wherein, if the additional heteroatom is nitrogen, the additional nitrogen can be substituted with lower alkyl with 1 to 4 carbon atoms, mono- or dialkylaminoalkyl or alkyloxyalkyl; R 6 represents hydrogen, halogen, straight or branched chain lower alkyl with 1 to 4 carbon atoms, or lower alkyloxy; R 7 represents hydrogen or halogen; and R 8 represents hydrogen or straight or branched chain lower alkyl with 1 to 4 carbon atoms; R 2 and R 3 independently represent hydrogen, lower alkyl with 1 to 3 carbon atoms; or together a lower alkylene group with 1 to 3 carbon atoms bridging the oxygen atoms and forming a five, six or seven membered ring; and R 4 represents hydrogen or lower alkyl with 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.