Patent ID: 8676608

Claim:
A method for warning of an adverse drug reaction or substance-factor interaction in a patient, which comprises: a) providing a computing machine, said computing machine in electronic communication with at least one computer-readable database and at least one user interface, wherein said computing machine is programmed to perform a predictive calculation, said calculation comprising: i) selecting culprits from a list of patient-specific factors stored in said at least one database, said culprits comprising prescription drug usage, substance usage, personal characteristic, phenotype, genotype, clinical factors, or combinations thereof, where a culprit is a factor having the property of being an inhibitor or an inducer, said culprits each having an intensity index INTX, where intensity index INTX indicates relative strength of inhibition or induction by each culprit; ii) selecting a sublist of victims from the list of patient specific factors, where a victim is a factor having the property of being a metabolic substrate of one or more metabolic routes; iii) identifying metabolic mutes associated with said sublist of victims; iv) identifying interaction pairs associated with said metabolic routes, each interaction pair defining a victim and a culprit having a known metabolic interaction on at least one metabolic route of the metabolic routes; v) for each victim of each interaction pair: calculating a CP score by multiplying the intensity index INTX associated with the culprit times a metabolic throughput proportion calculated as the metabolic throughput of each said metabolic route divided by a sum of the throughput of all metabolic pathways acting on the victim in parallel; vi) summing the CP scores for each victim and for each interacting pair, and tabulating the sums ΣCP; vii) from the sums ΣCP, calculating a predicted percent change AUC for each victim of each interacting pair; and, b) displaying a report on said at least one user interface, said report including a patient identifier, and if said percent change AUC for an interaction pair exceeds a threshold level, providing a warning of a potential patient-specific adverse reaction.