Patent ID: 8575113

Claim:
A method of inhibiting apoptosis in a cell comprising contacting the cell with a compound of Formula 1.2a, wherein: n is 0 or 1; m is 0, 1, or 2; Y is NH, O or S; R 1 is C 1 -C 6 optionally substituted with one R 6 substituent, R 1 a is 1) H, or 2) C 1 -C 6 alkyl optionally substituted with one R 6 substituent; R 2 is C 1 -C 6 optionally substituted with one or more halogens; R 3 is C 1 -C 6 alkyl optionally substituted with one R 6 substituent; R 4 is 1) H 2) —C(O)(O) n —R 11 , 3) —C(═Y)NR 8 R 9 , or 4) —S(O) 2 —R 11 R 5 is 1) C 1 -C 6 alkyl, 2) aryl, 3) heteroaryl, 4) C 1 -C 7 cycloalkyl, or 5) heterocyclyl; wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents; and wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; R 6 is: 1) halogen, 2) haloalkyl, 3) C 1 -C 6 alkyl, 4) C 3 -C 7 cycloalkyl, 5) aryl, 6) heteroaryl, 7) heterocyclyl, 8) —OR 7 , 9) —S(O) m R 7 , 10) —NR 8 R 9 , 11) —COR 7 , 12) —C(O)OR 7 13) —OC(O)R 7 , 14) —SC(O)R 7 , 15) —CONR 8 R 9 , 16) —S(O) 2 NR 8 R 9 , or 17) —NC(═Y)NR 8 R 9 wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; R 7 is: 1) H, 2) haloalkyl, 3) C 1 -C 6 alkyl, 4) C 3 -C 7 cycloalkyl, 5) aryl, 6) heteroaryl, 7) heterocyclyl, or 8) —C(═Y)NR 8 R 9 , wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents, and the aryl, heteroaryl, and heterocyclyl, are optionally substituted with one or more R 10 substituents; R 8 and R 9 are each independently 1) H, 2) haloalkyl, 3) C 1 -C 6 alkyl, 4) C 3 -C 7 cycloalkyl, 5) aryl, 6) heteroaryl, 7) heterocyclyl, 8) —C(O)R 11 , 9) —C(O)YR 11 , or 10) —SO 2 R 11 , wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents, and wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; or R 8 and R 9 together with the nitrogen atom to which they are bonded form a five, six, or seven membered heterocyclic ring optionally substituted with one or more R 6 substituents; R 10 is 1) halogen, 2) NO 2 , 3) CN, 4) C 1 -C 6 alkyl, 5) C 3 -C 7 cycloalkyl, 6) haloalkyl, 7) —OR 7 , 8) —NR 8 R 9 , 9) —SR 7 , 10) —COR 7 , 11) —C(O)OR 7 , 12) —S(O) m R 7 , 13) —CONR 8 R 9 , or 14) —SO 2 NR 8 R 9 , wherein the alkyl is optionally substituted with one or more R 6 substituents; and R 11 is 1) haloalkyl, 2) C 1 -C 6 alkyl, 3) C 3 -C 7 cycloalkyl, 4) aryl, 5) heteroaryl, 6) heterocyclyl, or 7) heterobicyclyl, wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents; and wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; or a salt thereof wherein the cell is a breast cancer cell, lung cancer cell, or ovarian cancer cell.