Patent ID: 8022192

Claim:
A method for preparing a glucopyranosyloxypyrazole derivative represented by the general formula: wherein Q 11 is a group represented by the general formula: in which PG 11 is an arylcarbonyl group, a pivaloyl group or an arylmethyl group, and R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different, each of them is a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a haloC 1-6 alkyl group, a C 3-6 cycloalkyl group, a C 3-6 cycloalkyloxy group, a C 3-6 cycloalkyl(C 1-6 alkoxy)group, a C 1-6 alkoxy group, a C 1-6 alkylthio group, a haloC 1-6 alkoxy group, an aryl group, an aryloxy group, a heteroaryl group, an aryl(C 1-6 alkyl) group, an aryl(C 1-6 alkoxy) group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a heteroC 3-6 cycloalkyl group, a heteroC 3-6 cycloalkyloxy group, a heteroC 3-6 cycloalkyl(C 1-6 alkyl)group, a C 1-6 alkoxy group substituted by an amino group which is mono-substituted by a C 1-6 alkyl group or a C 1-6 alkoxy group substituted by an amino group which is di-substituted by a C 1-6 alkyl group, and R 6 is a C 1-6 alkyl group, a haloC 1-6 alkyl group or a C 3-6 cycloalkyl group, which comprises allowing a benzylpyrazole derivative represented by the general formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the same meanings as defined above, and R 7 is a hydrogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group or an arylmethyloxy group to react with a compound represented by the general formula: in which PG 11 has the same meaning as defined above, and X 1 is a bromine atom or a chlorine atom in the presence of a base selected from the group consisting of potassium tert-butoxide, potassium carbonate, sodium carbonate and cesium carbonate to yield a glucopyranosyloxypyrazole derivative represented by the general formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have the same meanings as defined above, and subsequently removing R 7 CO— on the pyrazole ring.