Patent ID: 8465759

Claim:
A bioadhesive bi-layered hot-melt extruded laminate comprising a hydrophilic bioadhesive reservoir layer and a hydrophobic backing layer, wherein a) the bioadhesive reservoir layer comprises an active agent; b) each of the bioadhesive reservoir layer and the backing layer comprises poly(ethylene) oxide (PEO); and c) the backing layer comprises a hydrophilic polymer in a sufficiently low amount such that the backing layer is hydrophobic, wherein the PEO in each layer is selected from the group consisting of PEO Grade 1, PEO Grade 2, PEO Grade 3, and a combination thereof, wherein: PEO Grade 1 is polyethylene oxide with (i) a solution viscosity in the range of 12-8800 mPa·s at 25° C. in a 5% solution, or (ii) an approximate molecular weight range from 100,000-600,000; PEO Grade 2 is polyethylene oxide with (i) a solution viscosity in the range of 8800 mPa·S at 25° C. in a 5% solution to 4000 mPa·s at 25° C. in a 2% solution, or (ii) an approximate molecular weight range from 900,000-2,000,000; and PEO Grade 3 is polyethylene oxide with (i) a solution viscosity in the range of 1650-15,000 mPa-s at 25° C. in a 1% solution, or (ii) an approximate molecular weight range from 4,000,000-8,000,000, wherein the PEO in the bioadhesive reservoir layer comprises PEO Grade 1, PEO Grade 2, and PEO Grade 3.