Patent ID: 6984660

Claim:
A method for the treatment of endothelial dysfunction, which comprises administering to a patient in need thereof a pharmaceutically effective amount of one or more compounds of formula (I): in which the indicated radicals have the following meanings: R(1) is chosen from among 1. (C 1 -C 5 )-alkyl, unsubstituted or substituted by a radical chosen from among NH 2 , halogen, O—(C 1 -C 3 )-alkyl, CO—O—(C 1 -C 3 )-alkyl and CO 2 H; 2. (C 3 -C 8 )-cycloalkyl; 3. (C 1 -C 3 )-alkyl-(C 3 -C 8 )-cycloalkyl; 4. (C 6 -C 10 )-aryl, unsubstituted or substituted by a radical chosen from halogen and O—(C 1 -C 3 )-alkyl; 5. (C 1 -C 3 )-alkyl-(C 6 -C 10 )-aryl, where the aryl radical is unsubstituted or substituted by a radical chosen from halogen and O—(C 1 -C 3 )-alkyl; 6. (C 1 -C 5 )-heteroaryl; and 7. (C 1 -C 3 )-alkyl-(C 1 -C 5 )-heteroaryl; R(2) is chosen from among 1. hydrogen; 2. (C 1 -C 6 )-alkyl, unsubstituted or substituted by a radical chosen from halogen and O—(C 1 -C 3 )-alkyl; 3. (C 3 -C 8 )-cycloalkyl; 4. (C 1 -C 3 )-alkyl-(C 3 -C 8 )-cycloalkyl; 5. (C 6 -C 10 )-aryl, unsubstituted or substituted by a radical chosen from among halogen, O—(C 1 -C 3 )-alkyl and CO—O—(C 1 -C 3 )-alkyl; and 6. (C 1-C 3 )-alkyl-(C 6 -C 10 )-aryl, unsubstituted or substituted by a radical chosen from halogen and O—(C 1 -C 3 )-alkyl; R(3) is chosen from among 1. hydrogen; 2. COOH; and 3. COO—(C 1 -C 4 )-alkyl; R(4) is chosen from among 1. hydrogen; 2. halogen; and 3. (C 1 -C 4 -alkyl; R(5) is chosen from 1. hydrogen, and 2. (C 1 -C 6 )-alkyl; R(6) is chosen from among 1. hydrogen; 2. (C 1 -C 6 )-alkyl; 3. (C 1 -C 3 )-alkyl-(C 3 -C 8 )-cycloalkyl; and 4. (C 2 -C 6 )-alkenyl; X is chosen from 1. oxygen, and 2. NH; in all the stereoisomeric forms thereof, and mixtures thereof in all ratios, and the physiologically tolerated salts thereof.