Patent ID: 6852538

Claim:
An isolated oligonucleotide sequence comprising a response element that binds to a nuclear receptor of the Nur family of nuclear receptors, said response element comprising nucleotide sequence X 8 L 6 Y 8 , wherein: a) X 8 and Y 8 are two half site sequences of 8 nucleotides which are configured as an exerted repeat; b) L 6 separates said half site sequences, with L being 6 nucleotides and being independently selected from A,T,C,or G; c) X 8 having nucleotide sequence N 6 TT, and Y 8 having nucleotide sequence AAN 6 , wherein N is selected from A,T,C,or G, such that said sequence of X 8 and Y 8 share homology with the NBRE sequence defined by the hexanucleotide sequence AGGTCA (SEQ ID NO: 3) and its complement TGACCT (SEQ ID NO: 29), respectively, and wherein said response element is capable of binding to a dimer consisting of two partners which are selected from members of the Nur family of nuclear receptors.