Patent ID: 8785454

Claim:
A compound of Formula I-A: or a pharmaceutically acceptable salt thereof, wherein W 1 is N or CR 5 , W 2 is N or CR 6 , W 3 is N or CR 7 , W 4 is N or CR 8 , wherein no more than two N atoms are adjacent; R 1 is -(L) n —R 1 ; L is —S—, —N(R 2 )—, —C(R 3 ) 2 —, or —O—; n is 0 or 1; R 1 ′ is hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; R 4 , R 5 , R 6 , R 7 and R 8 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; X is absent or is —(CH(R 10 )) z — and z is an integer of 1, 2, 3, or 4; Y is absent, —O—, —S—, —S(═O)—, —S(═O) 2 —, —N(R 9 )—, —C(═O)—, —N(R 9 )—C(═O)—, —N(R 9 )—C(═O)NH—,)—N(R 9 )C(R 10 2 —, or —C(═O)—(CHR 10 ) z —; each instance of R 2 and R 9 is independently hydrogen, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, heterocycloalkyl, C 2 -C 10 heteroalkyl, aryl, or heteroaryl; each instance of R 3 and R 10 is independently hydrogen, alkyl, aryl, heteroaryl, or halo; and W d is wherein each instance of R a is independently hydrogen or alkyl; R 11 is H, alkyl, halo, amino, amido, hydroxyl, or alkoxy, and R 12 is H, alkyl, cyano, alkynyl, alkenyl, halo, aryl, heteroaryl, heterocyloalkyl, cycloalkyl, amino, carboxylic acid, acyloxy, alkoxycarbonyl, or amino.