Patent ID: 7168937

Claim:
A process for the separating enantiomers of aminomethyl-aryl-cyclohexanol compounds corresponding to formula I wherein X is chosen from H, F, Cl, Br, I, CF 3 , O—S(O 2 )—C 6 H 4 -pCH 3 , OR 14 or OC(O)R 14 , wherein R 14 is chosen from H; C 1 –C 10 -alkyl, C 2 –C 10 -alkenyl or C 2 –C 10 -alkinyl, in each case branched or unbranched and mono- or polysubstituted or unsubstituted; C 3 –C 7 -cycloalkyl, saturated or unsaturated and mono- or polysubstituted or unsubstituted, or a corresponding heterocyclic radical in which a C atom in the ring is replaced by N, S or O; alkylaryl or alkylheteroaryl, saturated or unsaturated and mono- or polysubstituted or unsubstituted; aryl or heteroaryl, in each case mono- or polysubstituted or unsubstituted; R 3 , R 4 independently of one another are chosen from H, C 1 –C 10 -alkyl, C 2 –C 10 -alkenyl or C 2 –C 10 -alkinyl, in each case branched or unbranched and mono- or polysubstituted or unsubstituted; C 3 –C 7 -cycloalkyl, saturated or unsaturated and mono- or polysubstituted or unsubstituted, or a corresponding heterocyclic radical in which a C atom in the ring is replaced by N, S or O; alkylaryl or alkylheteroaryl, saturated or unsaturated and mono- or polysubstituted or unsubstituted; aryl or heteroaryl, in each case mono- or polysubstituted or unsubstituted; or R 3 and R 4 together form a C 3 –C 7 -cycloalkyl, saturated or unsaturated and mono- or polysubstituted or unsubstituted, or a corresponding heterocyclic radical in which a C atom in the ring is replaced by S, O or NR 15 , where R 15 is chosen from H, C 1 –C 10 -alkyl, C 2 –C 10 -alkenyl or C 2 –C 10 -alkinyl, in each case branched or unbranched and mono- or polysubstituted or unsubstituted; R 1 and R 2 independently of one another are either H or any desired substituent and in each case one of the substituents R 5 and R 6 corresponds to H and the other corresponds to OH, characterized in that, depending on the desired enantiomer of the aminomethyl-aryl-cyclohexanol compounds corresponding to formula I comprising, according to reaction I, esterifying compounds corresponding to formula I and enzymatically transforming the compounds and separating enantiomerically pure compounds or comprising, according to reaction II, enzymatically transforming compounds corresponding to formula I in the presence of an ester and separating enantiomerically pure compounds.