Patent ID: 8653036

Claim:
A method of treating retinitis pigmentosa in a subject in need thereof comprising administering to said subject an effective amount of a β-turn peptidomimetic cyclic compound, wherein said β-turn peptidomimetic cyclic compound is represented by structural Formula (I): wherein R 1 and R 3 are independently selected from hydrogen, C 1 to C 6 alkyl, aryl, or amino acid side chain substituent found in the twenty protein-amino acids; R 2 and R 4 are independently hydrogen or alkyl; or R 1 and R 2 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group; or R 3 and R 4 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group; R 5 and R 6 are hydrogen or C 1 to C 6 alkyl; Y is hydrogen or one or two aromatic substituents; X is selected from O, N, S, P, Se, C, alkylene of 1 to 6 carbon atoms, SO, SO 2 or NH; n is 0, 1, 2, 3, 4 or 5; and LINKER selected from the group consisting of: NH 2 , OH, SH, COOH, CH 3 CO, CHO, and NH—CH 2 —COOH.