Patent ID: 8071570

Claim:
A mixture of sulfated oligosaccharides having the following characteristics: a mean molecular weight of from about 1500 daltons to about 3000 daltons, an anti-Xa activity of between 154.3 IU/mg and 192 IU/mg, an anti-IIa activity of less than about 10 IU/mg, and an anti-Xa activity/anti-IIa activity ratio of greater than about 30; wherein the constituent oligosaccharides of the mixture contain 2 to 26 saccharide units, wherein a portion of the constituent oligosaccharides of the mixture have a 4,5-unsaturated uronic acid 2-O-sulfate unit at one of their ends, and wherein the constituent oligosaccharides of the mixture contain a hexasaccharide fraction, wherein from about 8% to about 15% of the hexasaccharide fraction of the mixture is the hexasaccharide Î”IIa-II s -Is of formula: