Patent ID: 8835458

Claim:
A compound selected from the group consisting of a quinoline or quinazoline derivative of Formula (I), and a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof: wherein, Z is CH or N; X is C(═O) or CH 2 ; Y is hydrogen, —NR 6 R 7 , —NR 6 C(═O)R 7 , or —NR 6 C(═O)NR 6 R 7 ; n is an integer ranging from 0 to 3; R 1 is hydrogen, C 1-6 alkyl, C 1-6 alkanoyl, C 2-6 alkenoyl, or C 2-6 alkynoyl; R 2 is hydrogen or C 1-3 alkyl; R 3 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or C 3-6 alkynyloxyC 1-4 alkyl; R 4 and R 5 are each independently hydrogen, —O(CH 2 ) m —C 1-6 alkyl, —O(CH 2 ) m —C 3-6 cycloalkyl, —O(CH 2 ) m —C 3-6 heterocycloalkyl, —O(CH 2 ) m —C 5-10 aryl, —O(CH 2 ) m —C 5-10 heteroaryl or —O(CH 2 ) m —C 1-3 alkoxy, in which m is an integer ranging from 0 to 3; R 6 is hydrogen or C 1-6 alkyl; and R 7 is hydrogen, C 1-8 alkyl, —(CH 2 ) l —C 3-6 cycloalkyl, —(CH 2 ) l —C 3-6 heterocycloalkyl, —(CH 2 ) l —C 5-10 aryl or —(CH 2 ) l —C 5-10 heteroaryl, in which l is an integer ranging from 0 to 3; in which: said R 6 and R 7 are optionally linked together to form a ring structure; and said R 7 is optionally substituted with one or more substituents selected from the group consisting of halogen, —CF 3 , —NO 2 , —CN, C 1-8 alkyl, —(CH 2 ) p NR 8 R 9 , —(CH 2 ) p OR 10 , —(CH 2 ) p C(═O)R 11 , —(CH 2 ) p C(═O)OR 10 , —(CH 2 ) p C(═O)NR 8 R 9 , —(CH 2 ) p NR 8 C(═O)R 11 , —(CH 2 ) p SR 12 , —(CH 2 ) p S(═O)R 11 , —(CH 2 ) p S(═O) 2 R 11 , and —(CH 2 ) p —C 3-6 cycloalkyl, —(CH 2 ) p —C 3-6 heterocycloalkyl, —(CH 2 ) p —C 5-10 aryl and —(CH 2 ) p —C 5-10 heteroaryl, in which p is an integer ranging from 0 to 3; in which: said R 8 , R 9 , R 10 , R 11 and R 12 are each independently halogen, —CF 3 , —NO 2 , —CN, C 1-6 alkyl, —(CH 2 ) q —C 3-6 cycloalkyl, —(CH 2 ) q —C 3-6 heterocycloalkyl, —(CH 2 ) q —C 2-4 alkenyl, —(CH 2 ) q —C 2-4 alkynyl, —(CH 2 ) q —C 5-10 aryl or —(CH 2 ) q —C 5-10 heteroaryl, in which q is an integer ranging from 0 to 3; and said R 8 and R 9 are optionally linked together to form a ring structure.