Patent ID: 8853218

Claim:
A compound of formula (I): or a salt thereof, wherein: A is phenyl or a 6-membered heteroaryl ring, optionally substituted with one substituent selected from halogen, C( 1-4 )alkyl and C( 1-4 )alkoxy; R 1 and R 2 are independently H or C( 1-4 )alkyl, wherein one of R 1 and R 2 is other than hydrogen and the piperazinyl C* carbon has the S-configuration; R 3 is an optionally substituted phenyl, heteroaryl ring, or heterocyclic ring; B is an optionally substituted phenyl, 6-membered heteroaryl ring or 6-membered heterocyclic ring connected to the amide carbon via a carbon atom; Y is a bond, NH, N—C( 1-4 )alkyl, O, C═O, or CH 2 ; and R 4 is hydrogen, C( 1-4 )alkyl or C( 1-4 )alkoxyalkyl; wherein R 3 or B is optionally substituted by 1, 2 or 3 substituents, each independently selected from halogen, C (1-4) alkyl, C (1-4) alkoxy, C (3-7) cycloalkyl, hydroxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, phenyl, NH 2 , NHR 5 , NR 5 R 6 , NHCOR 5 , NHSO 2 R 5 , C(O)CF 3 , C(O)C (1-4) alkyl, C(O)C (3-7) cycloalkyl, C(O)OC (1-4) alkyl, C(O)OC ((3-7) cycloalkyl, OC(O)C (1-4) alkyl, OC(O)C (3-7) cycloalkyl, CONH 2 , CONHR 5 , CONR 5 R 6 , SOR 6 , SO 2 CF 3 , SO 2 R 6 , OSO 2 R 6 , OSO 2 CF 3 , SO 2 NH 2 , SO 2 NHR 5 , and SO 2 NR 5 R 6 , where R 5 and R 6 may be the same or different and represent C (1-4) alkyl, phenyl optionally substituted with halogen or 5 or 6 membered heteroaryl optionally substituted with halogen.