Patent ID: 6890421

Claim:
A method for determining the concentration of an analyte in a physiological sample, said method comprising: (a) introducing said physiological sample into an electrochemical cell comprising: (i) spaced apart working and reference electrodes; and (ii) a redox reagent system comprising an enzyme and a mediator; (b) applying a first electric potential having a first polarity to said reaction cell and measuring cell current as a function of time to obtain a first time-current transient; (c) applying a second electric potential having a second polarity to said cell, wherein said second polarity is opposite said first polarity, and measuring cell current as a function of time to obtain a second time-current transient; (d) deriving a preliminary analyte concentration from said first and second time-current transients; and (e) multiplying said preliminary analyte concentration less a background value by a correction factor to derive said corrected analyte concentration in said sample; whereby the corrected concentration of said analyte in said sample is determined.