Patent ID: 6951856

Claim:
A compound of the formula I wherein R 1 and R 2 are individually aryl or heteroaryl; R 3 is phenyl, mono-, di- or tri-substituted phenyl substituted with lower alkyl, lower alkenyl, lower alkynyl, phenyl, lower alkyloxy, amino, lower alkylamino, amino-lower alkyl, trifluoromethyl, trifluoromethoxy, halogen, lower alkylthio, hydroxy, hydroxy-lower alkyl, cyano, carboxyl, lower alkanoyl, formyl, benzofuranyl, aryl or heteroaryl; R 4 is hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkyl-amino, lower alkyloxy, lower alkyl-sulfono, lower alkyl-sulfinyl, lower alkylthio, lower alkylthio-lower alkyl, hydroxy-lower alkyl, lower alkyl-oxy-lower alkyl, hydroxy-lower alkyl-oxy-lower alkyl, hydroxy-lower alkyl-amino, lower alkyl-amino-lower alkyl, amino, di-lower alkyl-amino, [N-(hydroxy-lower alkyl)-N-(lower alkyl)]-amino, aryl, aryl-amino, aryl-lower alkyl-amino, aryl-thio, aryl-lower alkyl-thio, aryloxy, aryl-lower alkyl-oxy, aryl-lower alkyl, aryl-sulfinyl, heteroaryl, heteroaryl-oxy, heteroaryl-lower alkyl-oxy, heteroaryl-amino, heteroaryl-lower alkyl-amino, heteroaryl-thio, heteoroaryl-lower alkyl-thio, heteroaryl-lower alkyl, heteroaryl-sulfinyl, heterocyclyl, heterocyclyl-lower alkyl-oxy, heterocyclyl-oxy, heterocyclyl-amino, heterocyclyl-lower alkyl-amino, heterocyclyl-thio, heterocyclyl-lower alkyl-thio, heterocyclyl-lower alkyl, heterocyclyl-sulfinyl, cycloalkyl, cycloalkyl-oxy, cycloalkyl-lower alkyl-oxy, cycloalkyl-amino, cycloalkyl-lower alkyl-amino, cycloalkyl-thio, cycloalkyl-lower alkyl-thio, cycloalkyl-lower alkyl, cycloalkyl-sulfinyl; R 5 and R 6 are individually hydrogen or lower alkyl; X is oxygen, sulfur, NH, CH 2 or a bond; Y is oxygen, sulfur or —NH—; Z is oxygen, sulfur, —NH— or a bond; Q is —(CH 2 ) n or —(CH 2 ) m —C≡C—(CH 2 ) p —, and when p is the whole number 0, Z is a bond or —CH 2 -cyclopropylen-CH 2 —; n is the whole numbers 2, 3, 4, 5 or 6; m is the whole numbers 1, 2 or 3; p is the whole numbers 0, 1, 2 or 3; or pharmaceutically acceptable salts thereof.