Patent ID: 7446211

Claim:
A method for preparing 2-cyanopyrrole borate salts comprising combining: (a) a boron agent of the formula: (i) B(OR 1 )(OR 2 )OR 3 ), wherein: R 1 , R 2 , and R 3 are, independently, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 8 cycloalkyl, or substituted C 3 to C 8 cycloalkyl; or (ii) B(R 4 )(R 5 )(R 6 ), wherein: R 4 ,R 5 ,and R 6 are, independently, halogen, C 1 to C 6 alkyl, or substituted C 1 to C 6 alkyl; (b) a substituted 2-cyanopyrrole of the formula I: wherein: R 7 is C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or COR A ; R A is H, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 1 to C 6 alkoxy, substituted C 1 to C 6 alkoxy, C 1 to C 6 aminoalkyl, or substituted C 1 to C 6 aminoalkyl; Q a is H, OH, NH 2 , CN, halogen, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 2 to C 6 alkenyl, substituted C 2 to C 6 alkenyl, C 2 to C 6 alkynyl, substituted C 2 to C 6 alkynyl, C 1 to C 6 alkoxy, substituted C 1 to C 6 alkoxy, C 1 to C 6 aminoalkyl, substituted C 1 to C 6 aminoalkyl, or COR B ; a is 0 to 2; R B is H, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 1 to C 6 alkoxy, substituted C 1 to C 6 alkoxy, C 1 to C 6 aminoalkyl, or substituted C 1 to C 6 aminoalkyl; and (c) a strong non-nucleophilic base.