Patent ID: 7465726

Claim:
A compound represented by Formula I: or a pharmaceutically acceptable salt thereof, wherein X is C—CN; Cy is z is hetaryl, —C 1-6 alkyl-O—C 1-6 alkyl-, —C 0-6 alkyl-(heterocyclyl), —C 0-6 alkyl-(hetaryl), —C(O)—C 0-6 alkyl, —C(O)—C 0-6 alkyl-O—C 0-6 alkyl, —C(O)—C 0-6 alkyl-O—C 1-6 alkyl-O—C 0-6 alkyl, —C(O)—C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-(heterocyclyl), —C(O)—C 0-6 alkyl-(heterocyclyl)-C(O)—C 0-6 alkyl, —C(O)—C 0-6 alkyl-(hetaryl), —S(O) 2 —C 0-6 alkyl, —S(O) 2 —N(C 0-6 alkyl)(C 0-6 alkyl), or —S(O) 2 —(hetaryl), wherein any of the alkyl, heterocyclyl, or hetaryl optionally is substituted with 1-6 independent halo, OH, —C 0-6 alkyl-O—C 0-6 alkyl, —C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-(heterocyclyl), or —C 0-6 alkyl; in which the wavy bond is the point of attachment, and wherein the piperazine or morpholine moieties are optionally substituted with 1-6 independent C 0-6 alkyl groups; Y is —C(C 0-6 alkyl)(C 0-6 alkyl)-, —N(C 0-6 alkyl)-, —N(C 0-6 alkyl)-C 1-6 alkyl-, O, S, >N—C 2-6 alkyl-N—(C 0-6 alkyl)(C 0-6 alkyl), >N—C 2-6 alkyl-O—C 0-6 alkyl, >N—C 1-6 alkyl-C(O)—NH—C 0-6 alkyl, or >N—C 2-6 alkyl-N—C(O)—C 1-6 alkyl; and R1 is aryl, hetaryl, or heterocyclyl, optionally substituted with 1-6 independent halo, —CN, —OH, —C 0-6 alkyl, —C 3-10 cycloalkyl, -haloC 1-6 alkyl, —C 2-6 alkynyl, —N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-(heterocyclyl), —C 1-6 alkyl-C(O)—C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —O—C 0-6 alkyl-(heterocyclyl), —C 0-6 alkyl-O—C 0-6 alkyl, —C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —O—C 0-6 alkyl-(hetaryl), —S(O) 2 —N(C 0-6 alkyl)(C 0-6 alkyl), aryl, hetaryl, or heterocyclyl substituents, or substituted with an oxo (═O) using a bond from the aryl, hetaryl, or heterocyclyl ring, wherein any of the substituents optionally is substituted with 1-6 independent halo, CN, OH, —C 0-6 alkyl-O—C 0-6 alkyl, —C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-N(C 0-6 alkyl)(C 0-6 alkyl), —C(O)—C 0-6 alkyl-(heterocyclyl), or C 0-6 alkyl; or a pharmaceutically acceptable salt thereof.