Patent ID: 7071307

Claim:
A variant thioredoxin reductase (TR) protein with altered cofactor specificity as compared to a naturally occurring thioredoxin reductase protein comprising an isolated polypeptide molecule having the formula: S1-A1-A2-S2-A3-A4-A5-S3-A6-S4 wherein a) S1 comprises SEQ ID NO:6; b) S2 comprises SEQ ID NO:13; c) S3 comprises SEQ ID NO:20; d) S4 comprises SEQ ID NO:27; e) A1 is the amino acid serine; f) A2 is the amino acid is the amino acid alanine; g) A3 is the amino acid is the amino acid histidine; h) A4 is an amino acid moiety selected from the group consisting of arginine and tryptophan; i) A5 is an amino acid moiety selected from the group consisting of arginine, valine, leucine, isoleucine, methionine, phenylalanine, and tyrosine; j) A6 is an amino acid moiety selected from the group consisting of arginine, glycine, asparagine, glutamine, serine, and threonine, wherein only zero, one, or two of A4, A5 or A6 are arginine.