Patent ID: 7989187

Claim:
A process for the enhanced production of pantothenate, comprising culturing a recombinant microorganism selected from the group consisting of Bacillus, Corynebacterium, Lactobacillus, Streptomyces, Salmonella, Escherichia, Klebsiella, Serratia, Proteus , and Saccharomyces having (i) a deregulated pantothenate biosynthetic pathway, and (ii) a deregulated methylenetetrahydrofolate (MTF) biosynthetic pathway, under conditions such that pantothenate production is enhanced as compared to a wild-type microorganism, wherein the deregulated pantothenate biosynthetic pathway is achieved by overexpressing at least one gene selected from the group consisting of panB, panC, panD, and panE1, and wherein the deregulated MTF biosynthetic pathway is achieved by overexpressing at least one gene selected from the group consisting of gcv, serA, serC, serB, glyA, sul, fol, mtrA, pab, panB and purR derived from a microorganism of the genus Bacillus, Corynebacterium, Lactobacillus, Lactococci , or Streptomyces.