Patent ID: 7407661

Claim:
A method for generating a CD8 + T cell immune response in a human against hepatitis B comprising administering to said human at least one dose of each of the following: (i) a priming composition comprising one or more CD8 + T cell epitopes of hepatitis B, which are present in, or encoded by, a non-viral vector, or a viral vector that is non-replicating or replication-impaired in the human; and (ii) a boosting composition comprising a recombinant poxvirus vector encoding at least one of said one or more CD8 + T cell epitopes of hepatitis B, wherein the recombinant poxvirus vector is non-replicating or replication-impaired in the human; wherein the viral vector in (i) is derived from a different virus than the viral vector in (ii), and wherein the CD8 + T cell immune response against hepatitis B causes a reduction in hepatitis B viral load in the human.