Patent ID: 7816352

Claim:
A compound of formula I: wherein R 1 is —N(R b )(R c ), (C 3 -C 7 )cycloalkyl, aryl, or heteroaryl, or a 5-6 membered heterocyclic ring, optionally comprising 1, 2, or 3 —N(R b )—, nonperoxide O or S atoms; wherein R 1 is optionally substituted with 1, 2, 3, 4, or 5, halo, —CF 3 , hydroxy, cyano, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 2 -C 7 )alkanoyl, (C 2 -C 7 )alkanoyloxy, —CO 2 R a , (C 3 -C 7 )cycloalkyl, (C 2 -C 6 )alkanoyl, (C 2 -C 6 )alkenyl, or aryl groups; R 2 , R 3 , R 4 , R 5 , and R 6 are independently hydrogen, halo, hydroxy, cyano, —N(R b )(R c ), S(R a ), —NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkynyl, (C 2 -C 6 )alkenyl, (C 2 -C 7 )alkanoyl, (C 2 -C 7 )alkanoyloxy, or (C 3 -C 7 )cycloalkyl; or either R 2 and R 3 or either R 3 and R 4 taken together with the atoms to which they are attached form a benzo ring, optionally substituted with 1, 2, 3, or 4 R 6 groups, or either R 2 and R 3 or either R 3 and R 4 are a 3, 4, or 5 membered alkylene chain (e.g. —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, or —CH 2 CH 2 CH 2 CH 2 —) 3, 4, or 5 membered alkenylene, or methylenedioxy that is fused to the ring; each R 7 is independently hydrogen, halo, hydroxy, cyano, —N(R b )(R c ), —S(R a ), —NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkynyl, (C 2 -C 6 )alkenyl, (C 2 -C 7 )alkanoyl, (C 2 -C 7 )alkanoyloxy, or (C 3 -C 7 )cycloalkyl; wherein each R a is independently hydrogen, (C 1 -C 3 )alkyl, phenyl, benzyl, or phenethyl; and wherein R b and R c are each independently hydrogen, (C 1 -C 3 )alkyl, (C 2 -C 4 )alkanoyl, phenyl, benzyl, or phenethyl; or R b and R c together with the nitrogen to which they are attached are a 5 or 6 membered heterocyclic ring, optionally comprising 1, 2, or 3 —N(R a )—, nonperoxide O or S atoms, Z is —OR a , —SR a , or —N(R b)(R c ); m is 0, 1, 2, 3, or 4; X − is a pharmaceutically acceptable counterion.