Patent ID: 7927792

Claim:
A method of killing malignant glioma cells over expressing epidermal growth factor receptors (EGFR), the method comprising exposing the malignant glioma cells to a composition-of-matter comprising: (i) a double stranded RNA molecule, said molecule consisting of 2 RNA strands which induces viral-like double stranded RNA mediated apoptosis, triggered by up-regulation of interferon (IFN)-α/-β expression in said cell and/or tissue; (ii) a nucleic acid carrier comprising polyethylenimine (PEI); and (iii) a targeting moiety comprising epidermal growth factor (EGF), wherein, said double stranded RNA molecule is associated with said nucleic acid carrier, said nucleic acid carrier is associated with said targeting moiety and said targeting moiety is not covalently bound to said double stranded RNA molecule, and further wherein said double stranded RNA, said targeting moiety and said nucleic acid carrier form a particle which penetrates solid tumor tissue, thereby killing the malignant glioma cells.