Patent ID: 6872742

Claim:
A method of preventing or treating a chronic heart failure comprising administering to a mammal in need of such treatment, a safe and effective amount of a compound of having a structure according to Formula (I): wherein A is alkyl, heteroalkyl, aryl or heteroaryl, substituted or unsubstituted; R 1 is NHOR 2 , where R 2 is hydrogen or alkyl; W is one or more of hydrogen, lower alkyl, or an alkylene bridge that forms a ring in addition to the ring depicted in Formula (I); Y is independently one or more of hydroxy, SR 3 , SOR 4 , SO 2 R 8 , alkoxy, or amino, wherein the amino is of formula NR 6 ,R 7 , wherein R 6 and R 7 are independently chosen from hydrogen, alkyl, heteroalkyl, heteroaryl, aryl, OR 3 , SO 2 R 8 , COR 9 , CSR 10 , and PO(R 11 ) 2 ; R 3 is hydrogen, alkyl, aryl, or heteroaryl; R 4 is alkyl, aryl, or heteroaryl; each R 8 is independently chosen from group consisting of alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino and alkylarylamino; R 9 is hydrogen, alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino or alkylarylamino; R 10 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino or alkylarylamino; R 11 is alkyl, aryl, heteroaryl, or heteroalkyl; Z is hydrogen, hydroxy, alkyl, or an alkylene or heteroalkylene bridge that forms a ring in addition to the ring depicted in Formula (I); n is 1; and provided that (i) when any one or more of R 3 , R 4 , R 8 , R 9 , R 10 , R 11 , W, Y or Z is itself, or together with another moiety forms, a heterocyclic moiety, that heterocyclic moiety is furan, and (ii) when W or Z is an alkylene or heteroalkylene bridge that forms a second ring fused to the ring depicted in Formula (I), that second ring does not include the ring carbon atom depicted in Formula (I) that is bonded to C(═O)—R 1 ; or an optical isomer, diastereomer or enantiomer for Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.