Patent ID: 8784633

Claim:
A microelectrode sensing device, comprising: a substrate; and an array of microelectrode sensors formed on the substrate, each sensor comprising a first conductive layer, that at least partially conducts electricity, formed above the substrate and patterned to comprise a recording electrode to measure electrical activities of one or more target cells in a solution; a second conductive layer, that at least partially conducts electricity, elevated above the first layer and patterned to comprise a plurality of positioning electrodes arranged to define a sensing region above the recording electrode in which the solution is located, the positioning electrodes operable to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode; and an insulator material filled between the first conductive layer and the second conductive layer to electrically insulate the recording electrode from the positioning electrodes.