Patent ID: 8399437

Claim:
A method for treating spinal muscular atrophy, comprising administering to a subject having spinal muscular atrophy an effective amount of a tetracycline compound; wherein said compound is of formula I: wherein X is CR 6′ R 6 ; R 2 and R 2′ are each hydrogen; R 3 , R 4a , R 11 and R 12 are each hydrogen; R 4 is NR 4′ R 4″; R 4′ and R 4″ are each alkyl; R 5 and R 5′ are each hydrogen, alkyl, or hydroxyl; R 6 and R 6′ are each hydrogen or alkyl; R 7 is hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxyl, alkoxy, halogen, thioether, sulfinyl, sulfonyl, amino, cyano, nitro, carbonyl, aryl, heterocyclic or —(CH 2 ) 0-3 (NR 7c ) 0-1 C(=W′)WR 7a ; R 8 is hydrogen; R 9 is hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxyl, alkoxy, halogen, thioether, sulfinyl, sulfonyl, amino, cyano, nitro, carbonyl, aryl, heterocyclic or —(CH 2 ) 0-3 (NR 9c ) 0-1 C(=Z′)ZR 9a ; R 10 is hydroxyl; R 7a , R 7b , R 7c , R 7d , R 7e , R 7f , R 9a , R 9b , R 9c , R 9d , R 9e , and R 9f are each independently hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxyl, alkoxy, halogen, thioether, sulfinyl, sulfonyl, amino, cyano, nitro, carbonyl, aryl or heterocyclic; W is CR 7d R 7e , S, NR 7b or O; W′ is O, NR 7f , or S; Z is CR 9d R 9e , S, NR 9b or O; and Z′ is O, S, or NR 9f ; or a pharmaceutically acceptable salt, ester or enantiomer thereof.