Patent ID: 8222231

Claim:
A method of inhibiting angiogenesis, comprising administering to a subject suffering from abnormal angiogenesis a 2-O-desulfated glycosaminoglycan derivative with a iduronic acid desulfation degree not greater than 60% of the total uronic units, which has the following formula (I): where X and X′ are —CH 2 -D group, where D is selected from the group consisting of hydroxyl, amino acid,NH 2 , HN(CH 2 ) 2 SO 3 Na; R and R1, which are the same or different, are an SO 3 or acetyl residue; n and m, which are the same or different, vary from 1 to 40; the sum of n+m ranges from 6 to 40; the m:n ratio ranges from 10:2 to 1:1, and the symbol indicates that the units marked m and n are statistically distributed along the polysaccharide chain and are not necessarily in sequence.