Patent ID: 7396838

Claim:
A method of treating cancer, the cancer being leukemia or colorectal cancer, comprising administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein, R 1 is isoxazolyl, thiazolyl, isothiazolyl, 1,3,4-thiadiazolyl, or 1,3-benzothiazolyl, each being optionally substituted with 1-6 independent R 5 ; R 2 is H; R 3 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, or pyridyl, each being optionally substituted with 1-4 independent R 5 ; each R 4 is independently H, NO 2 , halo, CN, R 7 , or OR 7 ; each n is 0, 1, 2, 3, or 4; each R 5 is independently H, C1-C10 alkyl optionally substituted with 1-4 independent R 6 , C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, aryl optionally substituted with 1-4 independent R 6 , heteroaryl optionally substituted with 1-4 independent R 6 , halo, or haloalkyl; each R 6 is independently C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, halo, haloalkyl, CN, NO 2 , OR 7 , or SO 2 R 7 ; and each R 7 is independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, aryl, or heteroaryl.