Patent ID: 7087617

Claim:
A compound of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof wherein hydroxyl, amine or sulfylhydry groups are bonded to any group that cleaves to form free hydroxyl, amino or sulfhydryl group respectively, or a pharmaceutically acceptable salt of a prodrug thereof, wherein: X is —NR 3 R 4 ; G is N; R 1 and R 2 are independently selected from —H, —NH(alkyl), —N(alkyl) 2 , —NH(substituted alkyl), —N(substituted alkyl) 2 , —O(alkyl), —O(substituted alkyl), halogen, alkyl, substituted alkyl, haloalkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, —CR 5 R 5 Ar, —OAr, —S(O) m Ar, —NR 5 Ar, —S(O) m alkyl, —S(O) m substituted alkyl, —CN, —NO 2 , —OH, —NH 2 , —SH, —C(O)NR 4 R 5 and —C(S)NR 4 R 5 ; R 3 and R 4 are independently selected from and aryl cycloalkyl, substituted aryl cycloalkyl, provided that when both R 3 and R 4 are present one of the R 3 or R 4 is selected from a group provided herein above and the other R 3 or R 4 is selected from —H, alkyl, substituted alkyl, haloalkyl, cycloalkyl, substituted cycloalkyl, aryl, heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, substituted heteroaryl, aryl cycloalkyl, substituted aryl cycloalkyl, heteroaryl cycloalkyl, substituted heteroaryl cycloalkyl, aryl heterocycloalkyl, substituted aryl heterocycloalkyl, heteroaryl heterocycloalkyl, or substituted heteroaryl heterocycloalkyl; Ar is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl; and R 5 each is independently selected from —H, alkyl, cycloalkyl, and haloalkyl, wherein alkyl may be substituted with 1–3 substituents selected from halogen, —O(alkyl), —NH(alkyl), —N(alkyl) 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —NHC(O)alkyl, —N(alkyl)C(O)alkyl, and —S(O) m alkyl, heterocycloalkyl, substituted heterocycloalkyl and Ar.