Patent ID: 7304074

Claim:
A compound of the formula: wherein X is —S— or —NH—; R 1 is selected from the group consisting of a) hydrogen, b) lower alkyl that optionally may be substituted by (1) aryl that optionally may be substituted by lower alkyl, OH, lower alkoxy, halogen, or perfluoro-lower alkyl, (2) heteroaromatic that optionally may be substituted by lower alkyl, ═O, and —NH, or (3) heterocyclo lower alkyl, c) cyclo lower alkyl that optionally may be substituted by aryl, d) lower alkoxy-lower alkyl, R 2 is selected from the group consisting of a) cyano, b) hydrogen, c) CONR 6 R 7 , d) CO 2 R 8 , and e) lower alkyl optionally substituted by (1) OR 9 , (2) cyano, or (3) NR 6 R 7 ; R 3 selected from the group consisting of a) O-lower alkyl, b) S-lower alkyl, c) hydrogen, d) lower alkyl, e) cyclo lower alkyl, f) alkene, g) alkylene, h) NR 6 R 7 , i) COOR 8 , and j) CONR 6 R 7 , wherein, in each instance, lower alkyl, cyclo lower alkyl, lower alkene and lower alkylene may optionally be substituted by (1) OR 9 , (2) cyano, and (3) NR 6 R 7 , R 4 is selected from the group consisting of a) hydrogen, b) lower alkyl, c) O-lower alkyl, d) cyclo lower alkyl containing from 3 to 6 carbon atoms, and is selected from (1) an aryl ring, (2) a heterocyclo lower alkyl ring and (3) heteroaromatic ring; R 5 is selected from the group consisting of hydrogen and lower alkyl; R 6 and R 7 are each independently selected from the group consisting of a) hydrogen, b) lower alkyl which optionally may be substituted by (1) OR 9 , (2) halogen, (3) cyano, and (4) NR 12 NR 13 , and c) cyclo lower alkyl; R 8 is selected from the group consisting of lower alkyl that optionally may be substituted by OR 9 , cyano or NR 6 R 7 ; R 9 is selected from the group consisting of a) hydrogen, and b) lower alkyl that optionally may be substituted by (1) OR 12 , (2) cyano, or (3) NR 6 R 7 ; R 10 and R 11 are each independently selected from the group consisting of a) hydroxy, b) hydroxy-lower alkyl, c) hydrogen, d) lower alkyl, e) halogen, f) perfluro lower alkyl, and g) lower alkoxy; R 12 and R 13 are each independently selected from the group consisting of a) hydrogen, b) lower alkyl, and c) cyclo lower alkyl; and p is an integer from 0 to 6; or a pharmaceutically acceptable salt thereof.