Patent ID: 8088357

Claim:
A recombinant recognition molecule comprising variable heavy (VH) and variable light (VL) antibody framework sequences and complementarity determining regions (CDRs) comprising the amino acid sequences set forth in (i) the amino acid sequence SEQ ID NO. 1, (ii) the amino acid sequences SEQ ID NO.2 or 3, (iii) the amino acid sequence SEQ ID NO.4, 5 or 6, (iv) the amino acid sequence SEQ ID NO.7 or 8 or 9, (v) the amino acid sequence SEQ ID NO. 10 or 11, and (vi) the amino acid sequence SEQ ID NO. 12 or 13, wherein the antibody framework sequences a) FRH1, FRH2, FRH3 and FRH4 for the variable heavy chain VH are the following amino acid sequences, the amino acid position corresponding to the numbering according to Kabat: for FRH1 in position 1 Q or E 2 V 3 Q, K or T 4 L 5 K or V 6 E or Q 7 S 8 G 9 A 10 E 11 L or V 1.2 V or K 13 R or K 14 P 15 G 16 T or A 17 S 18 V 19 K 20 I or V 21 S or P 22 C 23 K 24 A, V, S or T 25 S 26 G 27 Y, F, S or D 28 T 29 F, L or I 30 T for FRH2 in position 36 W 37 V 38 K or R 39 Q 40 R or A 41 P 42 G 43 H or Q 44 G 45 L 46 E 47 W or R 48 I or M 49 G for FRH3 in position 66 K or R 67 A or V 68 T 69 L or M 70 T 71 A, L or T 72 D 73 T 74 S 75 S or T 76 S 77 T 78 A 79 Y 80 M 81 Q or E 82 L 82a S 82b S or R 82c L 83 T or R 84 S 85 E 86 D 87 S or T 88 A 89 V 90 Y 91 F or y 92 C 93 A 94 Y, K or R for FRH4 in position 103 W 104 G 105 Q 106 G 107 T 108 T, S or L 109 V or L 110 T 111 V 112 S 113 S or A b) FRL1, FRL2, FRL3 and FRL4 for the variable light chain VT, are the following amino acid sequences, the amino acid position corresponding to the numbering according to Kabat: for FRL1 in position 1 D 2 I, V or L 3 Q or L 4 M 5 T 6 Q 7 T or S 8 P 9 L 10 S 11 L 12 P 13 V 14 S or T 15 L or P 16 G 17 D or E 18 Q or P 19 A 20 S 21 I 22 S 23 C for FRL2 in position 35 W 36 Y 37 L 38 Q 39 K 40 P 41 G 42 Q 43 S 44 P 45 K or Q 46 L 47 L 4B I or V 49 Y for FRL3 in position 57 G 58 V 59 P 60 D 61 R 62 F 63 S 64 G 65 S 66 G 67 S 68 G 69 T 70 D 71 F 72 T 73 L 74 K 75 I 76 S 77 R 78 V 79 E 80 A 81 E 82 D 83 L or V 84 G 85 V 86 Y 87 Y 88 C for FRL4 in position 98 F 99 G 100 G or Q 101 G 102 T 103 K 104 L 105 E 106 I or L 106a K 107 R 108 A. and which specifically binds to the core 1 antigen.