Patent ID: 6872805

Claim:
A compound having the formula wherein: (a) R 1 is C 1-8 alkyl, C 3-7 cycloalkyl, or C 4-10 (alkylcycloalkyl), which are all optionally substituted from one to three times with halo, cyano, nitro, C 1-6 alkoxy, amido, amino or phenyl, or R 1 is C 6 or C 10 aryl which is optionally substituted from one to three times with halo, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, amido, amino or phenyl; (b) m is 1 or 2; (c) n is 1 or 2; (d) R 2 is C 1-6 alkyl, C 2-6 alkenyl or C 3-7 cycloalkyl, each optionally substituted from one to three times with halogen, or R 2 is H; (e) R 3 is C 1-8 alkyl optionally substituted with phenyl, C 3-12 alkenyl, C 3-7 cycloalkyl, or C 4-10 (alkylcycloalkyl), wherein the cycloalkyl or alkylcycloalkyl are optionally substituted with hydroxy, C 1-6 alkyl, C 2-6 alkenyl; or C 1-6 alkoxy or R 3 together with the carbon atom to which it is attached forms a C 3-7 cycloalkyl group optionally substituted with C 2-6 alkenyl; (f) Y is H, phenyl substituted with nitro, pyridyl substituted with nitro, or C 1-6 alkyl wherein said alkyl is optionally substituted with cyano, OH or C 3-7 cycloalkyl; (g) B is H, C 1-6 alkyl, R 4 —(C═O)—, R 4 O(C═O)—, R 4 —N(R 6 )—C(═O)—, R 4 —N(R 5 )—C(═S)—, R 4 SO 2 —, or R 4 —N(R 5 )—SO 2 —; (h) R 4 is (i) C 1-10 alkyl optionally substituted with phenyl, carboxyl, C 1-6 alkanoyl, 1-3 halogen, hydroxy, —OC(O)C 1-6 alkyl, C 1-6 alkoxy, amino optionally mono-or-di substituted with C 1-6 alkyl, amido, or (lower alkyl) amido; or —O-phenyl optionally substituted with halogen or C 1-6 alkoxy; (ii) C 3-7 cycloalkyl, C 3-7 cycloalkoxy, or C 4-10 alkylcyclo-alklyl, all optionally substituted with hydroxy, carboxyl, (C 1-6 alkoxy)carbonyl, amino optionally mono- or disubstituted with C 1-6 alkyl, amido, or (lower alkyl) amido; (iii) amino optionally mono-or-di-substituted with C 1-6 alkyl; amido; or (lower alkyl)amido; (iv) C 6 or C 10 aryl or C 7-16 aralkyl, all optionally substituted with C 1-6 alkyl, halogen, nitro, hydroxy, amido, (lower alkyl) amido, or amino optionally mono-or-di-substituted with C 1-6 alkyl; or (v) Het or (lower alkyl)-Het, both optionally substituted with C 1-6 alkyl, hydroxy, amido, (lower alkyl) amido, or amino optionally mono-or-di-substituted with C 1-6 alkyl; (vi) bicyclo(1.1.1)pentane; (vii) —C(O)OC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl; and (i) R 5 is H or C 1-6 alkyl, said C 1-6 alkyl optionally substituted with 1-3 halogens; or a pharmaceutically acceptable salt, solvate or prodrug thereof.