Patent ID: 8476420

Claim:
A composition for evaluating the existence or progression of a lung cancer in a mammalian subject, said composition consisting essentially of polynucleotides or oligonucleotides, wherein each polynucleotide or oligonucleotide hybridizes to a gene, gene fragment, or gene transcript of a different marker in a mammalian blood sample, each marker being one of the markers in the combination consisting of: (a) hepatitis B virus x associated protein (HBXAP or RSF1) (b) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) (c) YY1 transcription factor (YY1) (d) chromosome 19 open reading frame 12, transcript variant 1 (C19orf12); (e) thioesterase superfamily member 2 (THEM2) (f) triple functional domain (PTPRF interacting) (TRIO) (g) myeloid-associated differentiation marker, transcript variant 4 (MYADM) (h) BAI1-associated protein 2 (BAIAP2) (i) leucine zipper domain protein (FLJ22386 or ROGDI) (j) DnaJ (Hsp40) homolog, subfamily B, member 14 (DNAJB14) (k) brain and reproductive organ-expressed TNFRSF1A modulator (BRE), (l) transmembrane protein 41A (TMEM41A) (m) chromosome 9 open reading frame 64 (C9orf64) (n) chromosome 20 open reading frame 55, transcript variant 1 (C20orf55 or FAM110A), (o) pecanex-like 2 PCNXL2 (p) RE1-silencing transcription factor (REST) (q) HSPC142 protein (HSPC142 or C19orf62) (r) hypothetical protein BC015148 (LOC93081 or C13orf27) (s) activating signal cointegrator 1 complex subunit 3 (ASCC3) (t) solute carrier family 1, member 5 (SLC1A5) (u) protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1) (v) MRE11meiotic recombination 11 homolog A (MRE11A) (w) hypothetical protein or GTP-binding protein 10 (DKFZP686A10121 or GTPBP10) (y) Soares fetal liver spleen 1NFLS cDNA clone IMAGp998K18127 (z) serpin peptidase inhibitor, clade I (pancpin), member 2 (SERPINI2), (aa) cDNA FLJ44370 fis, clone TRACH3008902 or CAMP responsive element binding protein 1 (CREB1) (bb) coiled-coil domain containing 53 (CCDC53) (cc) ubiquitin specific peptidase 48 (USP48); and (dd) zinc finger and SCAN domain containing 2, transcript variant 3 (ZSCAN2).