Patent ID: 8247609

Claim:
A pharmaceutical composition, wherein it comprises: (a) at least one compound of the following formula (I): H 2 N—CH(R 1 )—CH 2 —S—S—CH 2 —CH(R 2 )—CONH—R 5 wherein: R 1 represents: a hydrocarbon chain, saturated or unsaturated, linear or branched, comprising from 1 to 6 carbon atoms, optionally substituted by: an OR, SR or S(O)R radical, wherein in each of these radicals R represents a hydrogen, a linear or branched hydrocarbon chain of 1 to 4 carbon atoms, a phenyl or benzyl radical, a phenyl or benzyl radical, a phenyl or benzyl radical optionally substituted by: 1 to 5 halogens, an OR, SR or S(O)R radical, wherein in each of these radicals R is defined as above, a methylene radical substituted by a 5- or 6-atom heterocycle, aromatic or saturated, having as a heteroatom an atom of nitrogen or sulfur, optionally oxidized in the form of N-oxide or S-oxide; R 2 represents: a phenyl or benzyl radical, optionally substituted by: 1 to 5 halogen atoms, an OR or SR radical, wherein in each of these radicals R is defined as above, an amino group optionally mono- or di-substituted by an aliphatic, cyclic or linear group of 1 to 6 carbon atoms, a 5- or 6-atom aromatic ring, R 5 represents: a CH(R 3 )—COOR4 radical wherein R 3 represents: hydrogen, an OH or OR group, with R as defined above, a saturated hydrocarbon chain (alkyl), linear or branched, comprising from 1 to 6 carbon atoms, optionally substituted by an OR or SR radical, wherein in each of these radicals R is defined as above, a phenyl or benzyl radical, optionally substituted by: 1 to 5 halogens, an OR or SR radical, with R as defined above; and OR 4 represents an OCH(R″)O(CO)OR′, wherein: R″ represents a hydrogen atom, a C1-C6 alkyl chain, linear or branched, optionally substituted by a C1-C3 alkoxy group, a C5-C8 cycloalkyl group, a phenyl, benzyl, heteroaryl, alkylheteroaryl group, and R′ represents: a saturated hydrocarbon chain (alkyl) with 1 to 6 carbon atoms, linear or branched and optionally substituted by a C1-C3 alkoxy group, a C5-C8 cycloalkyl group, a phenyl, benzyl, heteroaryl, alkylheteroaryl group; and additive salts of the aforesaid compounds (I) with pharmaceutically acceptable mineral or organic acids; (b) at least one compound selected from the group consisting of cannabinoid derivatives, morphine, morphine derivatives, Gabapentin and pregabalin; and (c) a pharmaceutically suitable excipient.