Patent ID: 7271170

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: Z 1 is nitrogen, Z 2 is nitrogen or CR 2 , and Z 3 is nitrogen or CR 3 , such that no more than two, of Z 1 , Z 2 and Z 3 are nitrogen; or Z 1 is CR 1 , Z 2 is nitrogen, and Z 3 is CR 3 ; R 1 , R 2 , and R 3 are each independently selected from: (a) hydrogen, halogen, nitro and cyano; and (b) groups of the formula: wherein: L is a bond or C 1 –C 8 alkylene; G is a bond, N(R B ), O C(═O), C(═O)O, C(═O)N(R B ), N(R B )C(═O), S(O) m , CH 2 C(═O), S(O) m N(R B ) or N(R B )S(O) m ; wherein m is 0, 1 or 2; and R A and each R B are independently selected from: (i) hydrogen; and (ii) C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, (C 3 –C 8 cycloalkyl)C 0 –C 4 alkyl, (3-to 7-membered heterocycloalkyl)C 0 –C 4 alkyl, (C 6 –C 10 aryl)C 0 –C 2 alkyl or (5-to 10-membered heteroaryl)C 0 –C 2 alkyl, each of which is substituted with from 0 to 4 substituents independently selected from halogen, hydroxy, nitro, cyano, amino, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, C 1 –C 4 alkanoyl, mono- and di(C 1 –C 4 alkyl)amino, C 1 –C 4 haloalkyl and C 1 –C 4 haloalkoxy; R 4 is hydrogen, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, or (C 3 –C 8 cycloalkyl)C 0 –C 4 alkyl; R 5 is: (a) hydrogen, halogen or cyano; or (b) C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 4 alkoxy or mono- or di-(C 1–C 4 alkyl)amino, each of which is substituted with from 0 to 5 substituents independently chosen from halogen, hydroxy, nitro, cyano, amino, C 1 –C 4 alkoxy, C 1 –C 2 haloalkyl, C 1 –C 2 haloalkoxy, mono- and di-(C 1 –C 4 alkyl)amino, C 3 -C 8 cycloalkyl, phenyl, phenylC 1 –C 4 alkoxy and 5- or 6-membered heteroaryl; R 6 and R 7 are independently hydrogen, methyl, ethyl or halogen; R 8 represents 0, 1 or 2 substituents independently chosen from halogen, hydroxy, nitro, cyano, amino, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, mono- and di(C 1 –C 4 alkyl)amino, C 3 -C 7 cycloalkyl, C 1 –C 2 haloalkyl and C 1 –C 2 haloalkoxy; and Ar represents phenyl, naphthyl, pyridyl, pyridazinyl, pyrimidinyl, thiazolyl or thienyl, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, nitro, cyano, amino, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, C 1 -C 8 alkoxy, (C 3 –C 7 cycloalkyl )C 0 –C 4 alkyl, (C 3 –C 7 cycloalkyl)C 1 –C 4 alkoxy, C 2 –C 8 alky ether, C 3 –C 8 alkanone, C 1 –C 8 alkanoyl, (3- to 7-membered heterocycloalkyl)C 0 –C 4 alkyl, C 1 –C 8 haloalkyl, C 1 –C 8 haloalkoxy, C 1 –C 8 hydroxyalkyl, C 1 –C 8 aminoalkyl, and mono- and di-(C 1 –C 8 alkyl)amino C 0 –C 8 alkyl.