Patent ID: 7834014

Claim:
A compound of the following formula: or a pharmaceutically acceptable salt or N-oxide thereof; wherein A is an aryl or heteroaryl; each of B, B 1 , and B 2 is N; each of R 2 and R 3 is independently hydrogen, alkyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkenyl, heteroaryl, or heteroaralkyl; X 1 is a bond or C 1-6 alkylene, C 2-6 alkenylene, or C 2-6 alkynylene, each of which being optionally interrupted by or linked terminally to —O—, —S—, or —N(R 2 )—; X 2 is a bond, C 1-6 alkylene, C 2-6 alkenylene, or C 2-6 alkynylene; L is a linker selected from the group consisting of: wherein: each of R′ and R″ is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, sulfoxy, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; X is —C(R 2 )(R 3 )—, —N(R 2 )—, —O—, or —S—; each of p, p1 and p2 is independently 0-2; each of q1 and q2 is independently 0-2; each of m1 and m2 is independently 0-2; each of r and r1 is independently is 1-2; and r2 is 0-1; Y is —C(R 2 )(R 3 )—, —N(R′″)—, —O—, —S—, —SO—, —SO 2 —, —CO—, —CO 2 —, or a bond where R″′ is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclyl, or heterocyclylalkyl; and R 1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclyl, or heterocyclylalkyl.