Patent ID: 8588881

Claim:
An analyte measurement system, comprising: at least one sensor introducer; a first electrochemical sensor having at least one electrode with an analyte response enzyme thereon, the first electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the first electrochemical sensor under a skin surface; a second electrochemical sensor having at least one electrode with an analyte response enzyme thereon, the second electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the second electrochemical sensor under a skin surface; and a device configured to normalize a signal obtained from the first electrochemical sensor with respect to a signal obtained from the second electrochemical sensor, to determine a standard deviation for a difference between the normalized signal of the first electrochemical sensor and the signal obtained from the second electrochemical sensor, to reject the signals of the first electrochemical sensor and the second electrochemical sensor that differ by more than the standard deviation, and to calibrate the signal obtained from the first electrochemical sensor based on a calibration factor.