Patent ID: 7399638

Claim:
A prediction method for lipidosis caused by a compound, which comprises: (1) detecting (a) phenylacetylglycine and/or phenylacetylglutamine, or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to phenylacetylglycine or phenylacetylglutamine, and (b) hippuric acid or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to hippuric acid, in a sample collected from a mammal receiving the compound or a mammalian cell or tissue culture exposed to the compound; and (2) predicting the compound's potential for inducing lipidosis with the quantitative ratio of (a):(b), (a):[(a)+(b)] or (b):[(a)+(b)] as an index, wherein when the quantitative ratio differs from the same quantitative ratio obtained in a sample collected from a mammal not receiving the compound or obtained from a mammalian cell or tissue culture not exposed to the compound, the compound is predicted to induce lipidosis.