Patent ID: 7141587

Claim:
A method for treating ophthalmic diseases in a mammal, comprising administering a compound of the Formula I or a pharmaceutically acceptable prodrug, pharmaceutically active metabolite, or a pharmaceutically acceptable salt thereof, wherein: R 1 is a substituted or unsubstituted aryl or heteroaryl, or a group of the formula CH═CH—R 3 or CH═N—R 3 , where R 3 is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and R 2 is a substituted or unsubstituted aryl or Y—Ar, where Y is O, S, C═CH 2 , C═O, S═O, SO 2 , CH 2 , CHCH 3 , NH, or N—(C 1 –C 8 alkyl), and Ar is a substituted or unsubstituted aryl; to the posterior chamber of the mammal's eye proximate the macula.