Patent ID: 8158623

Claim:
A method for the treatment of diabetes and metabolic syndromes in mammals, which comprises administering to mammals in need thereof a therapeutically effective amount of the compound of Formula (I), geometric isomers, enantiomers, diastereoisomers, racemates, pharmaceutically acceptable salts thereof or their mixtures; wherein, Ar 1 and Ar 2 are selected from benzene or heterocycle; X is O; Y is selected from O, N, S or SO 2 ; R 1 , R 2 , R 4 , R 5 , R 6 and R 8 are independently selected from hydrogen, unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted C 2 -C 10 alkenyl, unsubstituted or substituted C 2 -C 10 alkynyl, halo, —COOR′, —NR′R″, —OR′, —COR′, —CONR′R″, ═O, —SR′, —SO 3 R′, —SO 2 NR′R″, —SO 2 R′, —NO 2 or —CN; R 3 is independently selected from unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted C 2 -C 10 alkenyl, unsubstituted or substituted C 2 -C 10 alkynyl, halo, —COOR′, —NR′R″, —OR′, —COR′, —CONR′R″, ═O, —SR′, —SO 3 R′, —SO 2 NR′R″, —SOR′, —SO 2 R′, —NO 2 or —CN; when R 4 is substituted C 1 -C 10 alkyl, its substituent is selected from C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, halo, —COOR a , —NR a R b , —OR a , —COR a , —CONR a R b , ═O, —SR a , —SO 3 R a , —SO 2 NR a R b , —SOR a , SO 2 R a , —NO 2 , —CN; wherein R a and R b are selected from hydrogen, C 1-10 alkyl, C 2-10 alkenyl, or C 2-10 alkynyl; R 7 is independently selected from unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted C 2 -C 10 alkenyl, unsubstituted or substituted C 2 -C 10 alkynyl, halo, —COOR′, —NR′R″, —OR′, —COR′, ═O, —SR′, —SO 3 R′, —SO 2 NR′R″, —SOR′, —SO 2 R′, —NO 2 or —CN wherein R′ and R″ are independently selected from hydrogen, unsubstituted or substituted phenyl, unsubstituted or substituted benzyl, unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted C 2 -C 10 alkenyl, unsubstituted or substituted C 2 -C 10 alkynyl, or R′ and R″ are taken together to form a 4- to 7-membered ring.