Patent ID: 8324212

Claim:
A compound of formula I where: R 1 is halo, alkyl, cycloalkyl, alkoxy, dioxothiazinyl, (R 5 )(R 6 )N, pyridinyl or phenyl, where said pyridinyl or phenyl is substituted with 1-2 substituents selected from the group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, ((R 7 )(R 8 )N)alkyl, hydroxy, alkoxy, (R 7 )(R 8 )N, carboxy, alkoxycarbonyl, and CON(R 16 )(R 17 ), and where said pyridinyl or phenyl is also substituted with 0-2 halo, alkyl, alkoxy, pyridinyl, phenyl, halophenyl, (halo)(CON(R 7 )(R 8 ))phenyl, or (alkoxy)(CON(R 7 )(R 8 ))phenyl substituents; R 2 is hydrogen, halo, alkyl, cycloalkyl, alkoxy, or (R 5 )(R 6 )N; R 3 is cyano, alkoxycarbonyl, (cycloalkyl)oxycarbonyl, (alkylsulfonyl)aminocarbonyl, CON(R 11 )(R 12 ), (R 13 )(R 14 )NCONH, triazolyl, thiazolyl, or tetrazolyl; R 4 is phenyl substituted with 0-2 halo, alkoxy, phenoxy, or halophenoxy substituents; R 5 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, benzyl, alkylcarbonyl, haloalkylcarbonyl, phenylcarbonyl, (alkoxyphenyl)carbonyl, alkylsulfonyl, phenylsulfonyl, (alkoxyphenyl)sulfonyl or (haloalkoxyphenyl)sulfonyl; R 6 is hydrogen, alkyl, hydroxyalkyl, or alkoxyalkyl; or R 5 and R 6 taken together with the nitrogen to which they are attached is dioxothiazinyl; R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; or R 9 and R 10 taken together is ethylene, propylene, butylene, or pentylene, and is substituted with 0-2 flourine atoms; R 11 is hydrogen or alkyl; R 12 is hydrogen or alkyl; or R 11 and R 12 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl; R 13 is hydrogen or alkyl; R 14 is hydrogen or alkyl; or R 13 and R 14 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl; R 15 is alkyl or cycloalkyl; R 16 is hydrogen, alkyl, R 17 is hydrogen or alkyl; R 18 is hydrogen, halo, alkyl or alkoxy; and Ar 1 is isoxazolyl, oxazolyl, oxadiazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, or phenyl; and is substituted with 0-3 halo, alkyl, haloalkyl, alkoxy, (R 7 )(R 8 )N, or phenyl substituents; or a pharmaceutically acceptable salt thereof.