Patent ID: 8779118

Claim:
A bicyclic nucleoside having Formula I: wherein: one of T 1 and T 2 is H or a hydroxyl protecting group and the other of T 1 and T 2 is H, a hydroxyl protecting group or a reactive phosphorus group; q 1 and q 2 are each, independently, H, halogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, C 1 -C 6 alkoxyl, substituted C 1 -C 6 alkoxyl, acyl, substituted acyl, C 1 -C 6 aminoalkyl or substituted C 1 -C 6 aminoalkyl; Z 1 is NH 2 or NHPg and Z 2 together with Z 3 comprise a bond wherein Pg is a protecting group; or Z 1 and Z 2 together are ═X 2 and Z 3 is H; Q is thiazolyl or substituted thiazolyl; G is a diradical moiety selected from one or more linked groups, wherein each group is independently selected from —C(R 1 R 2 )—, —C(R 1 )═C(R 2 )—, —C(R 1 )═N—, —C[═C(R 1 R 2 )]—, —C(═O)—, —N(R 1 )—, —N(R 1 )—C(═X 3 )—, —O—, —S—, —S(═O)— or —S(═O) 2 — and wherein G forms a 5 or 6 membered ring with the furanose ring of the nucleoside; X 1 , X 2 and X 3 are each, independently, O or S; R 1 and R 2 are each independently, H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, C 1 -C 6 alkoxyl, substituted C 1 -C 6 alkoxyl, acyl, substituted acyl, C 1 -C 6 aminoalkyl or substituted C 1 -C 6 aminoalkyl; each substituted group comprises one or more optionally protected substituent groups independently selected from halogen, OJ 1 , N(J 1 )(J 2 ), ═NJ 1 , SJ 1 , N 3 , CN, OC(=L)J 1 , OC(=L)-N(J 1 )(J 2 ) and C(=L)N(J 1 )(J 2 ); L is O, S or NJ 3 ; and each J 1 , J 2 and J 3 is, independently, H, C 1 -C 6 alkyl.