Patent ID: 8629124

Claim:
A pharmaceutical composition comprising: (a) a functionalized dextran of the following general formula: wherein: each R′ independently represents —OH or —F—R-[AA] n , a molar fraction of substituent —F—R-[AA] n , per glycoside unit being from 0.1 to 2, m is the degree of polymerization and is from 10 to 10,000, R represents a chain containing from 1 to 18 carbon atoms and having at least one acid functional group prior to attachment to AA, the chain optionally being branched and/or unsaturated and optionally comprising one or more heteroatoms, F represents an ester, a thioester, an amide, a carbonate, a carbamate, an ether, a thioether or an amine, AA represents a hydrophobic amino acid radical, L- or D-isomer, derived from a coupling between an amine of an amino acid and the at least one acid functional group of R, the amino acid, prior to attachment to R, being selected from the group consisting of tryptophan, phenylalanine, leucine, isoleucine and valine, and alcohol, amide or decarboxylated derivatives thereof, and alkaline cation salts thereof, n represents a molar fraction of R groups substituted by AA and is from 0.05 to 1, when R is not substituted by AA, the acid(s) of the group R are alkaline cation carboxylates, and the functionalized dextran is amphiphilic at neutral pH; and (b) at least one active ingredient selected from the group consisting of proteins, glycoproteins, peptides and non-peptide therapeutic molecules.