Patent ID: 8252793

Claim:
A compound of Formula I: wherein, R 1 , R 2 independently=—CH 3 or —Cl; R 3 =C 1 -C 3 alkyl; A is: R 4 =—OR 5 , —NR 7 R 10 or —R 5 ; R 5 =C 1 -C 3 alkyl; X=—(CH 2 ) n —, —CF 2 CH 2 —; n=1-3; Y is: D 1 =N, CH, CR 5 , or COR 5 ; R 6 =—C(O)OR 10 , —N(R 10 )C(O)R 11 , —N(R 10 )S(O 2 )R 11 , —C(O)N(R 10 )(R 11 ), —N(R 10 )C(O)OR 11 , —N(R 10 )C(O)NR 7 R 11 , NR 10 R 12 , or —(CH 2 ) m NR 10 R 12 ; R 7 =H or C 1 -C 3 alkyl; R 8 =O, NC(O)R 11 , NS(O 2 )R 11 , NC(O)OR 11 , NC(O)NR 7 R 11 , or NR 11 ; R 9 =NC(O)R 11 , NS(O 2 )R 11 , NC(O)OR 11 , NC(O)NR 7 R 11 , or NR 11 ; R 10 =H or C 1 -C 3 alkyl; R 11 =H, C1-C4 alkyl, or —(CH 2 ) p —Z; R 12 =H, C 1 -C 3 alkyl, or —C(O)R 7 ; m=, 1-3; p=2-4; Z=—OH or —OR 12 ; R 13 =—N(R 10 )C(O)R 11 , —N(R 10 )S(O 2 )R 11 , —C(O)N(R 10 )(R 11 ), —N(R 10 )C(O)OR 11 , or —N(R 10 )C(O)NR 7 R 11 ; R 14 =—H, —CH 3 , or -cyclopropyl R 15 =—H, C 1 -C 4 alkyl, C(O)OR 11 , —C(O)N(R 10 )(R 11 ) or —(CH 2 ) m NR 10 R 12 ; W=-Q- or —NH—; B 1 is: D 2 =N, CH or CF; ; and B 2 is: D 2 =N, CH or CF.