Patent ID: 7939102

Claim:
A multiparticulate controlled release dosage formulation of lamotrigine or a pharmaceutically acceptable salt thereof, which comprises: (a) core particles, comprising lamotrigine and, said core particles being covered with a release rate controlling polymer selected from the group consisting of poly(ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride) 1:2:0.1; poly(ethyl acrylate, methyl methacrylate, trimethylamonioethyl methacrylate chloride) 1:2:0.2; polymethacrylic acid, ethyl acrylate 1:1; poly(ethyl acrylate, methyl methacrylate) 1:1or mixtures thereof wherein said release rate controlling polymer includes a plasticizer in the release rate controlling polymer; and (b) a rapidly disintegrating binder on said core particles which allows said core particles to rapidly disperse in an aqueous environment and is further characterized in that when orally administered to a human subject, said core particles will achieve a peak to trough plasma concentration ratio of between 1 to 1.6.