Patent ID: 7718769

Claim:
A method of making a compound of Formula (I) or pharmaceutically acceptable salt or ester thereof, wherein A and B are independently selected from R 1 , —C(O)R 1 , —C(O)OR 1 , —C(O)NR 3 R 4 , —C(S)NR 3 R 4 , or —S(O) n R 1 ; G is selected from —R 1 , —OR 1 , —C(O)R 1 , —C(O)OR 1 , —C(O)NR 3 R 4 , —NR 3 R 4 , or —N(R 3 )S(O) n R 1 ; W is selected from a substituted or unsubstituted heterocyclic, or a substituted or unsubstituted heteroaromatic; Each R 1 is independently selected from: hydrogen, deuterium, acyl, silane, a substituted or unsubstituted, saturated or unsaturated aliphatic group, a substituted or unsubstituted, saturated or unsaturated alicyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, or a substituted or unsubstituted heterocyclic group; Each of R 3 and R 4 is independently selected from: hydrogen, acyl, ester, optionally substituted amino acyl, a substituted or unsubstituted, saturated or unsaturated aliphatic group, a substituted or unsubstituted, saturated or unsaturated alicyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted heterocyclic group; or can be taken together with the nitrogen atom to which they are attached to form a substituted or unsubstituted heterocyclic or heteroaromatic ring; Each of R 5 and R 6 are independently selected from: hydrogen, deuterium, acyl, silane, a substituted or unsubstituted, saturated or unsaturated aliphatic group, a substituted or unsubstituted, saturated or unsaturated alicyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, or a substituted or unsubstituted heterocyclic group alkoxy, alkyl amine, hydroxy, hydroxyl amine, carboxy, ester, amine; m is 0, 1, or 2; n is 0, 1, or 2; and s is 1-6; comprising the step of reacting a compound of Formula (II) wherein W is a leaving group or hydroxy and all other variables are as defined in Formula (I), with a nucleophilic substituted or unsubstituted heterocyclic, or a nucleophilic substituted or unsubstituted heteroaromatic, thereby producing the compound of Formula I.