Patent ID: 8835451

Claim:
The compound of Formula I: A is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl E′ is —L2-E, —L2- is a divalent residue: —[R 1 ] a —[R 2 ] b —[C(O)] c —[N(R 3 )] d —[R 4 ] e —[R 5 ] f — selected from the group consisting of: a divalent alkyl group having from 1 to 4 carbon atoms a divalent alkenyl group having from 2 to 3 carbon atoms —C(O)—, —C(O)—[R 4 ] e —R 5 —, wherein e is 0 and R 5 is selected from the group consisting of a divalent substituted or unsubstituted C 1 -C 4 alkyl group, C 4 -C 8 cycloalkyl group, phenyl group or 5- or 6-membered heterocyclyl group, or e is 1, R 4 is a divalent substituted or unsubstituted C 1 -C 4 alkyl group, and R 5 is a divalent substituted or unsubstituted C 4 -C 8 cycloalkyl cycloalkyl group, phenyl group or 5- or 6-membered heterocyclyl group, —R 1 —R 2 —, wherein R 1 is a divalent substituted or unsubstituted C 1 -C 4 alkyl group and R 2 is a divalent substituted or unsubstituted C 4 -C 8 cycloalkyl group, phenyl group or 5- or 6-membered heterocyclyl group, —C(O)—NH—, —(CH 2 ) 1-3 —C(O)—NH—(CH 2 ) 1-3 —, —C(O)—NH—R 4 —, wherein R 4 is selected from a divalent substituted or unsubstituted C 1-7 alkyl group, cyclohexyl group or cyclopentyl group, —C(O)—N(R 3 )—R 4 —, wherein R 3 and R 4 and the N-atom together form a pyrrolidine ring or a piperidine ring, E is selected from the group consisting of: COOH, a carbocylic ester, a carboxamide, —S(O) 2 —OH, —S(O) 2 —NHR 6 , wherein R 6 is selected from hydrogen, a C 1 -C 8 alkyl group, a cycloalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclyl group, or a carboxylic acid ester group, or pharmaceutically acceptable salt thereof.