Patent ID: 7816349

Claim:
A compound structurally represented by the formula: or a pharmaceutically acceptable salt thereof, wherein R 1a is -halogen; R 1b is —H or -halogen; R 2 is —H, -halogen, —CH 3 (optionally substituted with 1 to 3 halogens), or —O—CH 3 (optionally substituted with 1 to 3 halogens); R 3 is -halogen, —CH 3 (optionally substituted with 1 to 3 halogens), or —O—CH 3 (optionally substituted with 1 to 3 halogens); R 4 is —H or -halogen; R 5 is wherein the dashed line represents the point of attachment to the R 5 position; wherein n is 0, 1, or 2, and wherein when n is 0, then “(CH 2 ) n” is a bond; wherein m is 1 or 2; R 6 is —H, —(C 1 -C 3 )alkyl (optionally substituted with 1 to 3 halogens), —(C 1 -C 3 )alkyl-O—R 20 , —(C 1 -C 3 )alkyl-pyrrolidinyl, phenyl, -HET 1 , -HET 2 , —CH 2 -phenyl, —CH 2 -HET 1 , —CH 2 -HET 2 , —(C 1 -C 3 )alkyl-N(R 20 )(R 20 ), —(C 1 -C 3 )alkyl-N + (O − )(CH 3 ), —(C 1 -C 3 )alkyl-C(O)N(R 41 )(R 41 ), —CH(C(O)OH)(CH 2 OR 20 ), —CH(C(O)OH)(CH 2 N(R 20 )(R 20 )), —(C 1 -C 3 )alkyl-C(O)O—R 20 , wherein the dashed line indicates the point of attachment to the position indicated by R 6 ; HET 1 is wherein the dashed line indicates the point of attachment to the position indicated by HET 1 ; HET 2 is wherein the dashed line indicates the point of attachment to the position indicated by HET 2 ; R 7 is —H, —(C 1 -C 3 )alkyl(optionally substituted with 1 to 3 halogens), or —(C 1 -C 3 )alkyl-O—R 20 ; R 8 is —H, —OH, —(C 1 -C 6 )alkyl(optionally substituted with 1 to 3 halogens), —(C 2 -C 3 )alkyl-O—R 20 , —C(O)(C 1 -C 6 )alkyl(optionally substituted with 1 to 3 halogens), —C(O)O—(C 1 -C 4 )alkyl(optionally substituted with 1 to 3 halogens), —C(O)—(C 3 -C 8 )cycloalkyl, —S(O 2 )—(C 3 -C 8 )cycloalkyl, —S(O 2 )—(C 1 -C 3 )alkyl (optionally substituted with 1 to 3 halogens) or —C(O)—N(R 20 )(R 20 ); R 9 is —H, -halogen, —CH 3 (optionally substituted with 1 to 3 halogens), or —O—CH 3 (optionally substituted with 1 to 3 halogens); R 10 is independently at each occurrence —H, or -halogen; R 11 is independently at each occurrence —H, —CH 3 or —CH 2 —CH 3 ; R 20 is independently at each occurrence —H, or —(C 1 -C 3 )alkyl (optionally substituted with 1 to 3 halogens); R 21 is independently at each occurrence —H, -halogen, or —(C 1 -C 3 )alkyl; R 22 is independently at each occurrence —H or —(C 1 -C 6 )alkyl (optionally substituted with 1 to 3 halogens); R 23 is independently at each occurrence —H, —(C 1 -C 4 )alkyl, or —C(O)O—(C 1 -C 4 )alkyl; R 24 is independently at each occurrence —H, -halogen, or —(C 1 -C 3 )alkyl (optionally substituted with 1 to 3 halogens); R 31 is independently at each occurrence —H, -halogen, or —C 1 -C 3 )alkyl; and R 41 is independently at each occurrence —H, or —CH 3 .