Patent ID: 7153878

Claim:
A compound of the formula Formula I: and pharmaceutically acceptable salts thereof, wherein; (a) R3 is selected from the group consisting of hydrogen, (C 1 –C 4 )alkyl, halo, and (C 1 –C 6 )alkoxy; (b) R4 is methyl; (c) R30 and R40 are each hydrogen; (d) R5 is selected from the group consisting of (C 2 –C 4 )alkyl, (C 1 –C 6 )alkenyl, aryl(C 0 –C 4 )alkyl, aryloxy(C 0 –C 4 )alkyl, arylthio(C 0 –C 4 )alkyl, wherein said aryl(C 0 –C 4 )alkyl, aryloxy(C 0 –C 4 )alkyl, and arylthio(C 0 –C 4 )alkyl are each independently optionally substituted with from one to three substituents each independently selected from R5′, and further wherein when R5 is alkyl, R5 can optionally combine with W to form a 6 membered cycloheteroalkyl ring that is fused with the oxazole or thiazole ring to which the R5 group is attached; (e) R5′ are each independently selected from the group consisting of halo, —(O)—(C 1 –C 5 )alkylCOOH, C 1 –C 5 alkyl, C 1 –C 5 alkylCOOH, and CF 3 ; (f) R6 is selected from the group consisting of trihalomethyl, trihalomethoxy, hydroxyl(C 0 –C 3 )alkyl, (C 1 –C 4 )alkyl, (C 1 –C 6 )alkyINC(O)—, tetramethyldioxaborolanyl, halo, —C(O)(C 1 –C 4 )alkyl, —O—(C 1 –C 2 )alkyl-CO 2 H, aryloxy, arylthio, —C(O)N(C 1 –C 6 )alkyl, (C 1 –C 4 )alkoxy, tetrahydropyranyloxy, morpholinyl, (C 5 –C 6 )cycloalkyloxy, (C 5 –C 6 )heterocyclo-oxy, pyridinyl, pyrimidinyl, pyrazinyl and aryl(C 0 –C 4 )alkyl, wherein said pyridinyl, pyrimidinyl, pyrazinyl, aryl(C 0 –C 4 )alkyl, aryloxy, (C 5 –C 6 )heterocyclo-oxy, and arylthio are each optionally substituted with from one to three substituents independently selected from R6′; (g) R6′ and R9′ are each independently selected from the group consisting of CF 3 , C 1 –C 4 alkyl, halo, hydroxy(C 1 –C 3 )alkyl, C 1 –C 3 alkoxy, and —C(O)CH 3 ; (h) R7 and R8 are each independently selected from the group consisting of hydrogen, CF 3 , and (C 1 –C 3 )alkyl; (i) R9 is selected from the group consisting of C 1 –C 5 alkyl, C 1 –C 5 alkenyl, and arylC 0 –C 3 alkyl, wherein said arylalkyl is optionally substituted with from one to three substituents each independently selected from R9′; (j) R10 is selected from the group consisting of hydrogen, and C 1 –C 5 alkyl; (k) Q is selected from the group consisting of O, a single bond, and CH 2 ; (l) T 1 is C; (m) W is selected from the group consisting of CH 2 , C(O)N(R21), N(R21), N(R21)CH 2 , O, OCH 2 , S, and SO 2 ; (n) R21 is selected from the group consisting of hydrogen and C 1 –C 2 alkyl; (o) X is selected from the group consisting of C, CH 2 C, and CCH 2 ; (p) Y and Z are each independently selected from the group consisting of O, N and S, wherein at least one of Y and Z is selected from the group consisting of O and S; (q) A is an functional group selected from the group consisting of carboxyl, C 1 –C 3 alkylnitrile, carboxamide, and (CH 2 ) n COOR19; (r) n is 0, 1, 2 or 3; (s) R19 is selected from the group consisting of hydrogen, and C 1 –C 3 alkyl; and (t) Further provided that when O is O and R5 is methyl, then R9 is benzyl.