Patent ID: 8598135

Claim:
A method of treating a tumor in a subject, the method comprising: identifying a subject having, at risk for, or suspected of having a tumor; providing a sample comprising a cell from the tumor; detecting in the sample one or more of: (i) a level of Ras-BRAF-MEK-Erk signaling; (ii) dependence of growth or survival of the cell on Ras-BRAF-MEK-Erk signaling; or (iii) expression of an activated or oncogenic BRAF or RAS; determining that a cell of the tumor has increased Ras-BRAF-MEK-Erk signaling as compared to a predetermined reference level of Ras-BRAF-MEK-Erk signaling, is dependent for growth and/or survival upon the Ras-BRAF-MEK-Erk signaling pathway, and/or expresses an activated or oncogenic BRAF or RAS; and administering to the subject an effective amount of an IGFBP7 polypeptide, thereby treating the tumor.