Patent ID: 8030483

Claim:
A method for preparing a compound of formula (I), or a salt or N-oxide thereof, comprising contacting a compound of the formula, with a compound of the formula, under suitable reaction conditions to provide the compound of formula (I), wherein each R 1 is independently selected from the group consisting of hydrogen, lower alkyl, —(CH 2 ) n —OH, —OR a , —O(CH 2 ) n —R a , —O(CH 2 ) n —R b , —C(O)OR a , halo, —CF 3 and —OCF 3 ; each R 2 is independently selected from the group consisting of hydrogen, lower alkyl, —OR a , —O(CH 2 ) n —R a , —O(CH 2 ) n —R b , —NHC(O)R a , halo, —CF 3 , —OCF 3 , each R 3 is independently selected from the group consisting of hydrogen, lower alkyl, —(CH 2 ) n —OH, —OR a , —O(CH 2 ) n —R a , —O(CH 2 ) n —R b , halo, —CF 3 , —OCF 3 , each R 4 is independently selected from the group consisting of hydrogen, lower alkyl, arylalkyl, —OR a , —NR c R c , —C(O)R a , —C(O)OR a and —C(O)NR c R c ; R 5 is hydrogen, halo, fluoro, —CN, —NO 2 , CO 2 R a or —CF 3 ; each n is independently an integer from 1 to 3; each R a is independently selected from the group consisting of hydrogen, lower alkyl and lower cycloalkyl; each R b is independently selected from the group consisting of —OR a , —CF 3 , —OCF 3 , —NR c R c , —C(O)R a , —C(O)OR a , —C(O)NR c R c and —C(O)NR a R d ; each R c is independently selected from the group consisting of hydrogen and lower alkyl, or, alternatively, two R c substituents may be taken together with the nitrogen atom to which they are bonded to form a 5-7 membered saturated ring which optionally includes 1-2 additional heteroatomic groups selected from O, NR a , NR a —C(O)R a , NR a —C(O)OR a and NR a —C(O)NR a ; each R d is independently lower mono-hydroxyalkyl or lower di-hydroxyalkyl; and X is a halogen.