Patent ID: 7550498

Claim:
A compound of the formula I wherein X is CH 2 or a hetero atom selected from O, S, S(═O), S(═O) 2 , and NR a , wherein R a is hydrogen or a protecting group; Y and Z independently from each other denote one or more identical or different substituents linked to any available carbon atom, selected from H, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkinyl, halo-C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, trifluoromethoxy, C 1 -C 4 alkanoyl, amino, amino-C 1 -C 4 alkyl, N—(C 1 -C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, thiol, C 1 -C 4 alkylthio, sulfonyl, C 1 -C 4 alkylsulfonyl, sulfinyl, C 1 -C 4 alkylsulfinyl, carboxy, C 1 -C 4 alkoxycarbonyl, cyano, and nitro; R 1 is H, halogen, an optionally substituted heteroaryl or heterocycle, hydroxy, C 1 -C 7 alkoxy, aryloxy, amino, N—(C 1 -C 7 )alkylamino, N,N-di(C 1 -C 7 -alkyl)amino, (C 1 -C 7 -alkyl)amino, amino-C 1 -C 7 alkoxy, C 1 -C 7 alkanoyl, aroyl, C 1 -C 7 alkanoyloxy, carboxy, an optionally substituted C 1 -C 7 alkyloxycarbonyl or aryloxycarbonyl, carbamoyl, N—(C 1 -C 7 -alkyl)carbamoyl, N,N-di(C 1 -C 7 -alkyl)carbamoyl, cyano, nitro, or a substituent of the formula II: wherein R 3 and R 4 simultaneously or independently from each other are selected from hydrogen, C 1 -C 4 alkyl, aryl or together with N have the meaning of an optionally substituted heterocycle and heteroaryl; m and n represent an integer from 0 to 3; Q 1 and Q 2 represent, independently from each other, oxygen, sulfur or groups wherein the substituents Y 1 and Y 2 independently from each other are selected from hydrogen, halogen, an optionally substituted C 1 -C 4 alkyl or aryl, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkanoyl, thiol, C 1 -C 4 alkylthio, sulfonyl, C 1 -C 4 alkylsulfonyl, sulfinyl, C 1 -C 4 alkylsulfinyl, cyano, nitro or together form carbonyl and imino group; R 2 has the meaning of hydrogen, optionally substituted C 1 -C 7 alkyl or aryl or a protecting group: formyl, C 1 -C 7 alkanoyl, C 1 -C 7 alkoxycarbonyl, arylalkyloxycarbonyl, aroyl, arylalkyl, C 1 -C 7 alkylsilyl; or Dimethyl-{2-[2-(8-thia-1,2-diaza-dibenzo[e,h]azulene-1-yl)-ethoxy]-ethyl}-amine; Dimethyl-{3-[2-(8-thia-1,2-diaza-dibenzo[e,h]azulene-1-yl)-ethoxy]-propyl}-amine; Dimethyl-{2-[2-(8-thia-1,2-diaza-dibenzo[e,h]azulene-2-yl)-ethoxy]-ethyl}-amine; Dimethyl-{3-[2-(8-thia-1,2-diaza-dibenzo[e,h]azulene-2-yl)-ethoxy]-propyl}-amine; as well as pharmacologically acceptable salts thereof.