Patent ID: 6995284

Claim:
A process for preparing a selective androgen receptor modulator (SARM) compound having in-vivo androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor, said compound represented by the structure of formula I: wherein X is O, T is OH, OR, NHCOCH 3 , or NHCOR; Z is NO 2 , CN, COOH, COR, NHCOR or CONHR; Y is CF 3 , F, I, Br, Cl, CN, CR 3 or SnR 3 ; Q is halogen, CN NHCOCH 3 or NHCOCF 3 , R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 . CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ; said process comprising the step of coupling an amide of formula II: wherein Z, Y R 1 and T are as defined above and L is a leaving group, with a compound of formula III: wherein Q and X are as defined above.