Patent ID: 7709448

Claim:
A compound of Formula I wherein R 1 is NH 2 or —N═CHNR 6 R 7 , R 2 is H, OH, or —OR 5 , R 3 is OH, —OC(O)C 1 -C 18 alkyl, —OCO 2 R 5 , —OC(O)NR 6 R 7 , or a racemic, L-, or D-amino acid group —OC(O)CHR 8 NHR 9 , R 4 is OH, —OC(O)C 1 -C 18 alkyl, —OCO 2 R 5 , —OC(O)NR 6 R 7 , or a racemic, L-, or D-amino acid group —OC(O)CHR 8 NHR 9 , R 5 is —C 1 -C 7 alkyl, R 6 and R 7 are independently —C 1 -C 7 alkyl or together with nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring, R 8 is H or —C 1 -C 7 alkyl, R 9 is H, —C 1 -C 7 alkyl, —C(O)R 5 , or —CO 2 R 5 , wherein at least one of R 3 or R 4 is —OCO 2 R 5 , —OC(O)NR 6 R 7 , or a racemic, L-, or D-amino acid group —OC(O)CHR 8 NHR 9 , wherein the above alkyl is optionally substituted by 1-4 substituents selected from hydrogen, alkylamine, amino, aryl, cycloalkyl, heterocyclyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms, carboxyl, cyano, halo, hydroxy, mercapto, oxo, thioalkyl, —C(O) 2 —(C 1 -C 6 alkyl), —C(O) 2 -(aryl), —C(O) 2 -(cycloalkyl), —C(O) 2 -(heterocyclyl), —O—(C 1 -C 6 haloalkyl), —O-aryl, —O-heterocyclyl, —NHC(O)—(C 1 -C 6 alkyl), —NHC(O)—(C 1 -C 6 alkenyl), —NHC(O)-(aryl), —NHC(O)-(cycloalkyl), —NHC(O)-(heterocyclyl), —NHS(O) 2 —(C 1 -C 6 alkyl), —NHS(O) 2 -(aryl), —NHS(O) 2 -(cycloalkyl), and —NHS(O) 2 -(heterocyclyl), wherein each of the above substituents can be further optionally substituted by 1-5 substituents selected from amino, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkenyl, C 1 -C 6 hydroxyl, and C 1 -C 6 hydroxyalkyl, each optionally substituted by cyano, halo, and nitro, or a pharmaceutically acceptable salt or stereoisomer thereof.