Patent ID: 7026306

Claim:
A method of providing biologically active estrogen compounds to a mammal, wherein said method comprises administering to the mammal an effective amount of a quinol that is convened to a biologically active estrogen compound via enzyme-catalyzed reduction, wherein the quinol has the general structure: wherein R is selected from the group consisting of H, alkyl, cycloalkyl, aryl, heterocycle, heteroaryl, alkylamino, hydroxyalkyl, alkoxyalkyl, and alkylaryl; X is selected from the group consisting of hydrogen, halogen, isopropyl, alkyl, alkenyl, alkynyl, carbocycle, cycloalkyl, aryl, heterocycle, heteroaryl, alkylamino, hydroxyalkyl, alkoxyalkyl, and a linear or branched hydrocarbon from 1–15 carbon atoms in length, that can optionally include one or more heteroatoms in the chain; Y is selected from the group consisting of hydrogen, halogen, isopropyl, alkyl, alkenyl, alkynyl, carbocycle, cycloalkyl, aryl, heterocycle, heteroaryl, alkylamino, hydroxyalkyl, alkoxyalkyl, and a linear or branched hydrocarbon from 1–15 carbon atoms in length, that can optionally include one or more heteroatoms in the chain; and Z is selected from the group consisting of hydrogen, halogen, isopropyl, alkyl, alkenyl, alkynyl, carbocycle, cycloalkyl, aryl, heterocycle, heteroaryl, alkylamino, hydroxyalkyl, alkoxyalkyl, and a linear or branched hydrocarbon from 1–15 carbon atoms in length, that can optionally include one or more heteroatoms in the chain.