Patent ID: 8875704

Claim:
A nasal delivery device for delivering g powdered sumatriptan substance to a nasal cavity of a human subject, the delivery device comprising: a nosepiece for fitting to the nasal cavity of the subject, and a capsule-containing member which contains a capsule, the capsule containing the powdered sumatriptan substance to be delivered to the nasal cavity of the subject, wherein the capsule-containing member includes a flow passage in which the capsule is disposed to be rotatable therewithin when an air flow is delivered therethrough, the flow passage including an inlet and an outlet which is in fluid communication with the nosepiece, wherein the device is configured such that, when the nosepiece is fitted to the nasal cavity of the subject, oral exhalation by the subject through the nosepiece acts to close the velum of the subject and drive an air flow through the nasal cavity, with the air flow passing into one nasal passage and out the other nasal passage, thereby achieving a bi-directional air flow, and wherein the powdered sumatriptan substance has a particle size distribution of 10% less than about 20 μm, 50% less than about 50 μm and 90% less than about 150 μm.