Patent ID: 7603239

Claim:
A method for making an antimicrobial peptide, comprising the steps of determining a set of patterns of primary amino acid sequences being representative of a peptide having antimicrobial activity in a database of antimicrobial peptides selected from the group consisting of AMSDb and SWISS-PROT, providing a set of randomly generated peptide sequences at least ten amino acids in length, correlating the set of patterns with the randomly generated peptide sequences by calculating the S score, selecting at least one of said randomly generated peptide sequences having a score S= 16/21 or 0.73 or higher and mutating the selected peptide sequence, repeating the step of correlating the set of patterns with the mutated peptide sequences to identify mutated peptide sequences having a score S= 16/21 or 0.73 or higher scored peptide sequences, selecting an identified peptide sequence, and synthesizing the peptide sequence.