Patent ID: 8802861

Claim:
A thiazole according to Formula (I), wherein R 1 is a moiety of the formula —NR 5 R 6 ; R 2 , R 3 and R 5 are selected independently from the group consisting of H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl and C 2 -C 6 -alkynyl; R 4 is selected from the group consisting of H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl and NR 8 R 9 , wherein R 8 and R 9 are independently selected from the group consisting of H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkyl alkoxy carbonyl and C 1 -C 6 -alkyl acyloxy; R 6 is an unsubstituted group selected from the group consisting of C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkyl alkoxy, C 1 -C 6 alkyl acyl, C 1 -C 6 -alkyl carboxy, C 1 -C 6 alkyl C 3 -C 8 cycloalkyl, C 1 -C 6 alkyl heterocycloalkyl, C 1 -C 6 -alkyl acylamino, C 1 -C 6 -alkyl amino, C 1 -C 6 -alkyl aminocarbonyl, C 1 -C 6 -alkyl alkoxycarbonyl, 2-acetylamino-phenyl, 3-nitro phenyl, 2-nitrophenyl, 2-methylphenyl, 2-chlorophenyl, 3-chlorophenyl, 2-hydroxyphenyl, 4-hydroxyphenyl, cyanophenyl, 3-(1-hydroxyethyl)phenyl, hydroxamic acid phenyl, 3-(N-hydroxycarbamimidoyl)-phenyl-4-yl, benzyl piperazine carbonyl phenyl, phenyl substituted with heteroaryl, dimethylpyrimidine amino sulfonyl phenyl, methyl isoxazol amino sulfonyl phenyl, dimethoxy pyrimidine amino sulfonyl phenyl, pyridinyl amino sulfonyl phenyl, 3-(aminosulfonyl)phenyl, 4[(methylamino)sulfonyl]phenyl, 4-[(dimethylamino)sulfonyl]phenyl, 3 [(butylamino)sulfonyl]phenyl, 4-(morpholin-4-yl-sulfonyl)phenyl, aryl sulfonyl, fused phenyl, 3-pyridine, 4-pyridine, methoxy pyridine, chloro pyridine, fluoro pyridine, cyano pyridine, acetamide pyridine, fused pyridine, C 3 -C 8 cycloalkyl, pyridine-3-yl-methyl, pyridine-4-yl-methyl, 2-(1H-tetrazol-5-yl)ethyl, 2-(2-hydroxy-1,3,4-oxadiazol-5-yl)ethyl, 3-(2-hydroxy-1,3,4-oxadiazol-5-yl)propyl, and 3-(1H-imidazol-1-yl)propyl; or R 5 and R 6 , together with the carbon atoms they are linked to, form an unsubstituted 5-8-membered saturated ring or aromatic ring containing optionally one or more heteroatoms selected from the group consisting of 0, N and S; and X is S; as well as isomers thereof.