Patent ID: 7291645

Claim:
A compound of formula I: wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, or R 1 and R 2 , together with the nitrogen atom to which they are attached, are joined to form an optionally substituted heterocyclic ring provided that said substituted alkyl, substituted alkenyl and substituted cycloalkyl do not carry an aryl, substituted aryl, heteroaryl or substituted heteroaryl group; R 4 and R 5 are independently selected from the group consisting of -L 2 (Alk 3 ) t L 3 (R 7 ) u in which L 2 and L 3 are independently selected from the group consisting of a covalent bond, a linker atom, and a linker group, wherein the linker atom is selected from —O—and —S—, and the linker group is selected from —C(O)—, —C(O)O—, —OC(O)—, —C(S)—, —S(O)—, —S(O) 2 —, —NR 11 —, —CON(R 11 )—, —OC(O)N(R 11 )—, —CSN(R 11 —, —N(R 11 )CO—, —N(R 11 )C(O)O—, —N(R 11 )CS—, —S(O) 2 N(R 11 )—, —N(R 11 )S(O) 2 —, —N(R 11 )CON(R 11 ), —N(R 11 )CSN(R 11 )—, and —N(R 11 )SO 2 N(R 11 )— groups, t is zero or the integer 1, u is an integer 1, 2, or 3, Alk 3 is an aliphatic or heteroaliphatic chain, and R 7 is hydrogen or halogen atom or a group selected from alkyl, —OR 8 , —SR 8 , —NR 8 R 9 , —NO 2 , —CN, —CO 2 R 8 , —SO 3 H, —SOR 8 , —SO 2 R 8 , —OCO 2 R 8 , —CONR 8 R 9 , —CSNR 8 R 9 , —COR 8 , —OCOR 8 , —N(R 8 )COR 9 , —N(R 8 )CSR 9 , —SO 2 N(R 8 )(R 9 ), —N(R 8 )SO 2 R 9 , —N(R 8 )CON(R 9 )(R 10 ), —N(R 8 )CSN(R 9 )(R 10 ) or —N(R 8 )SO 2 N(R 9 )(R 10 ); R 8 is a hydrogen atom or an optionally substituted alkyl group; R 9 is a hydrogen atom or an optionally substituted alkyl group; R 10 is a hydrogen atom or an optionally substituted alkyl group; R 11 is a hydrogen atom or an optionally substituted alkyl group; Alk 2 is a straight or branched alkylene chain; m is zero or an integer 1; R 6 is a hydrogen atom or a methyl group; R is a carboxylic acid (—CO 2 H) group or a derivative thereof selected from lower alkyl ester derivative, a carboxamide group, or an N-lower alkyl carboxamide group, R a is a hydrogen or a methyl group; Ar is an optionally substituted aromatic group; and the salts, hydrates and N-oxides thereof.