Patent ID: 6875786

Claim:
A compound represented by the following Formula (I): wherein: R, R 1 , R 2 and R 3 are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, —(CH 2 ) p OR 4 , —C(O)OR 4 , formyl, nitro, cyano, halogen, aryl, substituted aryl, substituted alkyl, —S(O) n R 4 , cycloalkyl, —NR 5 R 6 , protected —OH, —CONR 5 R 6 , phosphonic acid, sulfonic acid, phosphinic acid and —SO 2 NR 5 R 6 , where p is 0-6, n is 0-2, R 4 is hydrogen, alkyl, cycloalkyl, C 1 -C 12 aryl, substituted alkyl, substituted cycloalkyl and substituted C 1 —C 12 aryl, and R 5 and R 6 are each independently selected from hydrogen, alkyl, substituted alkyl, C 3-6 cycloalkyl, and aryl, or R 5 and R 6 taken together with the nitrogen to which they are attached represent a 5 to 6 member saturated ring containing up to one other heteroatom selected from oxygen and nitrogen; R 0 is selected from hydrogen, C 1 -C 10 alkyl and substituted C 1 -C 10 ; m is 0-6; and AR is a cyclic or polycyclic aromatic ring containing from 3 to 16 carbon atoms and optionally containing one or more heteroatoms, provided that when the number of carbon atoms is 3 the aromatic ring contains at least two heteroatoms and when the number of carbon atoms is 4 the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of: alkyl, substituted alkyl, aryl, substituted cycloalkyl, substituted aryl, aryloxy, oxo, hydroxy, alkoxy, cycloalkyl, acyloxy, amino, N-acylamino, nitro, cyano, halogen, —C(O)OR 4 , —C(O)NR 10 R 11 , —S(O) 2 NR 10 R 11 , —S(O) n R 4 and protected —OH, where n is 0-2, R 4 is hydrogen, alkyl, cycloalkyl, C 1 -C 12 aryl, substituted alkyl, substituted cycloalkyl and substituted C 1 -C 12 aryl; and R 10 and R 11 are independently hydrogen, cycloalkyl, C 1 -C 12 aryl, substituted cycloalkyl, substituted C 1 -C 12 aryl, alkyl or alkyl substituted with one or more substituents selected from the group consisting of: alkoxy, acyloxy, aryloxy, amino, N-acylamino, oxo, hydroxy, —C(O)OR 4 , —S(O) n R 4 , —C(O)NR 4 R 4 , —C(O) 2 NR 4 R 4 , nitro, cyano, cycloalkyl, substituted cycloalkyl, halogen, aryl, substituted aryl and protected —OH, or R 10 and R 11 taken together with the nitrogen to which they are attached represent a 5 to 6 member saturated ring containing up to one other heteroatom selected from oxygen and nitrogen, where R 4 is as described above and n is 0-2; and pharmaceutically acceptable salts, hydrates, solvates and esters thereof; provided that at least one of R, R 1 , R 2 and R 3 is a substituted aryl group.