Patent ID: 8088748

Claim:
A method, comprising: immunizing a subject against pulmonary inflammation and airway hyperresponsiveness associated with infantile respiratory syncytial virus infection by administering an antisense oligonucleotide to a subject, wherein: a) the subject is an infant and said antisense oligonucleotide is administered as part of a respiratory syncytial virus vaccination; b) said antisense oligonucleotide is between 10 and 40 nucleotides in length; c) said antisense oligonucleotide is targeted to a nucleic acid molecule encoding IL-4Rα; d) the first 5 and last 5 nucleotides at the 5′ and 3′ ends of the antisense oligonucleotide are 2′-O-methoxyethyl nucleotides, the nucleotides between the first 5 and last 5 nucleotides at the 5′ and 3′ ends are 2′-deoxynucleotides, every intemucleoside linkage is a phosphorothioate linkage, and every cytidine residue is a 5-methylcytidine.