Patent ID: 7109185

Claim:
A pharmaceutical formulation for oral or parenteral administration comprising: a therapeutically effective amount of a compound of Formula (I), (II), (III), or (IV): wherein: R 2 is hydrogen; R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethane-sulfonamido, carbonyl, C-carboxy, O-carboxy, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, amino and —NR 11 R 12 where R 11 and R 12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, acetyl, sulfonyl and trifluoromethanesulfonyl, or R 11 and R 12 , together with the nitrogen atom to which they are attached, combine to form a five- or six-membered heteroalicyclic ring provided that at least two of R 3 , R 4 , R 5 and R 6 are hydrogen; or R 3 and R 4 , R 4 and R 5 , or R 5 and R 6 combine to form a six-membered aryl ring, a methylenedioxy or an ethylenedioxy group; R 7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, carbonyl, acetyl, C-amido, C-thioamido, amidino, C-carboxy, O-carboxy, sulfonyl and trifluoromethanesulfonyl; R 8 , R 9 and R 10 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, carbonyl, C-carboxy, O-carboxy, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, amino, -(alk 1 )Z (where alk 1 is selected from the group consisting of alkyl, alkenyl and alkynyl and Z is hydroxy, alkoxy, carboxy, nitro, cyano, amino, guanidino, amido, ureido, sulfonamido, sulfinyl, sulfonyl, phosphonate, morpholino, piperazinyl or tetrazolyl) and —NR 11 R 12 wherein R 11 and R 12 are as defined above; R 1′ is hydrogen or alkyl; R 2′ is hydrogen, alkyl, aralkyl, acyl or —P(O)(OR)(OR′); R 3′ and R 4′ are independently alkyl, or R 3′ and R 4′ , together with the nitrogen atom to which they are attached, combine to form a heterocyclic ring or a heteroaryl ring; R 5′ is alkyl; R and R′are independently selected from the group consisting of hydrogen, alkyl, aralkyl and aryl; and R a and R b are independently selected from hydrogen and alkyl; or a pharmaceutically acceptable salt thereof; at least one pharmaceutically acceptable complexing agent or surfactant; a pharmaceutically acceptable diluent; and at least one or more of each of a pharmaceutically acceptable acid or base, a polyoxyhydroxycarbyl compound, a pharmaceutically acceptable alcohol, and at least one antioxidant; or a combination of at least one pharmaceutically acceptable acid or base and at least one antioxidant.