Patent ID: 6960574

Claim:
An article of manufacture comprising packaging material and a pharmaceutical agent contained within said packaging material, wherein said pharmaceutical agent is effective for the treatment of a subject suffering from opiate addiction, and wherein said packaging material comprises a label which indicates that said pharmaceutical agent can be used for ameliorating the symptoms associated with opiate addiction, and wherein said pharmaceutical agent is selected from the group consisting of compounds having the formula: where R 1 =H, C 1 -C 6 alkyl, cycloalkyl, R 2 =H, C 1 -C 6 alkyl, cycloalkyl W=C n H 2n-m —NH (n=1-6, m=0, 2, or 4), X= R 3 = Y= Z=CONR 8 (CH 2 ) n , CONR 8 (CH 2 ) n CO, P(CH 3 )OCHR 8 OCOR 9 , SO 2 , SO 2 (CH 2 ) n , SO 2 (CH 2 ) n CO, SO 2 NR 8 (CH 2 ) n , SO 2 NR 8 (CH 2 ) n CO, n=1-4 R 4 =H, (CH 2 ) n OH, (CH 2 ) n OCOR 10 , (CH 2 ) n NR 10 R 11 , (CH 2 ) n CONR 10 R 11 , n=0-4 R 5 =H, (CH 2 ) n NR 12 R 13 , n=0-4 R 6 =H, (CH 2 ) n NR 14 R 15 , n=0-4 R 7 =H, C 1 -C 6 alkyl, cycloalkyl; R 8 =H, C 1 -C 6 alkyl, cycloalkyl; R 9 =H, C 1 -C 6 alkyl, cycloalkyl; R 10 =H, C 1 -C 6 alkyl, cycloalkyl; R 11 =H, C 1 -C 6 alkyl, cycloalkyl; R 12 =H, C 1 -C 6 alkyl, cycloalkyl; R 13 =H, C 1 -C 6 alkyl, cycloalkyl; R 14 =H, C 1 -C 6 alkyl, cycloalkyl; R 15 =H, C 1 -C 6 alkyl, cycloalkyl Dashed lines: optional; conformational constraint by (CH 2 ) n , n=1-3; R′=H or O(═).