Patent ID: 6957150

Claim:
A method for identifying an agent that interacts with an active site of acyl carrier protein synthase (ACPS), comprising the steps of: (a) obtaining a crystallized ACPS, wherein the crystallized ACPS is characterized as being in plate form with space group P2 1 , and having unit cell parameters of a=76.26 Å, b=76.16 Å, c=85.69 Å, and beta=93.3°, and wherein ACPS is cloned and isolated from B. subtilis; (b) obtaining the structural coordinates of the crystallized ACPS of step (a), wherein the structural coordinates are set forth in FIG. 1 and 1 A- 1 to 1 A- 107 ; (c) generating a three dimensional model of ACPS using the structural coordinates of the amino acids of ACPS obtained in step (b), and ± a root mean square deviation from the backbone atoms of not more than 1.5 Å; (d) determining an active site of ACPS from said three dimensional model; and (e) performing computer fitting analysis to identify an agent which interacts with said active site.