Patent ID: 7829572

Claim:
A compound of formula I wherein R 1 is -Q or (C 1 -C 6 )alkyl-Q; R 2 is pyridyl wherein said pyridyl is substituted with hydroxy and additionally is optionally substituted with one to three substituents independently selected from halo, cyano, trifluoromethyl, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or hydroxy; R 3 is hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )alkyl-Q, aryl, heteroaryl, OR 6 , or NR 7 R 8 ; wherein said (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, aryl or heteroaryl is optionally substituted with one to three substituents independently selected from halo, cyano, trifluoromethyl, trifluoromethoxy, (C 1 -C 6 )alkyl; (C 1 -C 6 )alkoxy, NR 7 R 8 or hydroxy; R 4 and R 5 are each independently hydrogen, halo, cyano, (C 1 -C 6 )alkyl optionally substituted with one to three fluoro, aryl, heteroaryl, or OR 6 ; R 6 at each occurrence is independently (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl, aryl, heteroaryl, (C 1 -C 6 )alkylaryl, or (C 1 -C 6 )alkylheteroaryl; each of said (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl, aryl, heteroaryl, (C 1 -C 6 )alkylaryl, or (C 1 -C 6 )alkylheteroaryl optionally substituted with one to three substituents independently selected from halo, hydroxy or (C 1 -C 3 )alkyl; R 7 and R 8 , at each occurrence, are independently hydrogen, (C 1 -C 6 )alkyl, or (C 3 -C 7 )cycloalkyl; or R 7 and R 8 taken together with the nitrogen to which they are attached form a 3 to 7 membered fully saturated ring optionally containing one to two additional heteroatoms independently selected from N(R 9 ) n ; O or S(O) p ; n is 1; p is 0, 1 or 2; R 9 is hydrogen or (C 1 -C 6 )alkyl; Q, at each occurrence, is independently aryl or heteroaryl; wherein said aryl or heteroaryl is optionally substituted with one to three substituents independently selected from halo, cyano, trifluoromethyl, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or hydroxy; or a pharmaceutically acceptable salt thereof.