Patent ID: 8907071

Claim:
A DNA encoding a composition of matter for extending the half-life of a polypeptide, of the formula (X 1 ) a —(F 1 ) d —(X 2 ) b —(F 2 ) e —(X 3 ) c or multimers thereof, wherein: F 1 and F 2 are half-life extending moieties selected from: (i) a human IgG Fc domain or a portion thereof, (ii) a transthyretin protein domain, and (iii) a human serum albumin (HSA) protein domain; and d and e are each independently 0 or 1, provided that at least one of d and e is 1; X 1 , X 2 , and X 3 are each independently -(L) f -P-(L) g -, and f and g are each independently 0 or 1; P is a polypeptide of no more than about 80 amino acid residues in length, comprising the amino acid sequence of SEQ ID NO: 914, SEQ ID NO: 915, SEQ ID NO: 916, or SEQ ID NO: 917; L is a linker; and a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1.