Patent ID: 8886274

Claim:
A noninvasive method for estimating a variation of glucose level ΔG in the blood of a person within a time interval Δt, comprising the following steps: placing a first tetrapolar electrode device in contact with skin of the person overlying a portion of soft tissue including muscular fibers oriented parallel to the direction of the muscular fibers; placing a second tetrapolar electrode device in contact with the skin of said person overlying said portion of soft tissue oriented transverse to the direction of the muscular fibers; measuring for a time interval Δt: with the first tetrapolar electron device a relative variation ΔC ∥,LF /C ∥,LF of the conductivity value C ∥,LF of said tissue parallel to the direction of the muscular fibers at a low frequency; with the second tetrapolar electron device a relative variation ΔC ⊥,LF /C ⊥,LF of a conductivity value C ⊥,LF of said tissue transverse to the direction of the muscular fibers at said low frequency; estimating ΔG by a processing apparatus as: 0.0 if Δ C ∥,LF /C ∥,LF ≈ΔC ⊥,LF /C ⊥,LF + a if Δ C ∥,LF /C ∥,LF >ΔC ⊥,LF /C ⊥,LF − a if Δ C ∥,LF /C ∥,LF <ΔC ⊥,LF /C ⊥,LF wherein: a is in the range of 0.15-1.0 μM/l sec; the low frequency is in the range of 1·×10 4 Hz-5·×10 4 Hz; and “≈” means “equal within a range of +/−2.5%-+/−7.5%”.