Patent ID: 8158643

Claim:
Compound according to Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein: A is a radical according to Formula (II) wherein k, l, m, n are each independently from each other, an integer equal to 0, 1, 2, 3, or 4, with the provision that (k+1) and (m+n) is equal to 2, 3, 4, or 5; wherein one of the —CH 2 -moieties may be replaced by O; and wherein each of the —CH 2 -moieties may be substituted with oxo; X is C or N; R 3 is selected from the group of hydrogen, C 1-5 alkyl, C 3-6 cycloalkyl, and C 1-5 alkyloxycarbonyl; R 4 , R 5 are each, independently from each other, selected from the group of hydrogen, halo, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio, formyl, C 1-3 alkyl, and C 1-3 alkyloxy; p is an integer, equal to zero, 1, 2, or 3; q is an integer, equal to zero, 1, 2, or 3; Y 1 , Y 3 are each, independently from each other, selected from the group of a single bond, O, NR 7 , S, SO, and SO 2 ; wherein R 7 is selected from the group of hydrogen and C 1-3 alkyl; Y 2 is a saturated or unsaturated, straight or branched C 1-6 -hydrocarbon radical, wherein one or more hydrogen atoms may optionally be replaced by a radical selected from the group of halo, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio, and formyl; B is a 6-membered ring containing zero, 1, 2 or 3 nitrogen atoms, optionally substituted with r substituents R 6 , each independently from each other, selected from the group of halo, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio, formyl, C 1-3 alkyl, and C 1-3 alkyloxy; and wherein r is an integer, equal to 1 or 2; or two substituents R 6 may be combined into a radical —CH 2 CH 2 CH 2 — or —OCH 2 O—; alkyl is a straight or branched saturated hydrocarbon radical having the indicated number of carbon atoms; wherein the radical may optionally be substituted on one or more carbon atoms with one or more radicals selected from the group of halo, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio, and formyl; aryl is naphthyl or phenyl, each optionally substituted with 1, 2 or 3 substituents, each independently from each other selected from the group of halo, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio, formyl, C 1-3 alkyl, and C 1-3 alkyloxy; Het is a heterocyclic radical selected from the group of pyrrolidinyl; imida-zolidinyl; pyrazolidinyl; piperidinyl; piperazinyl; pyrrolyl; pyrrolinyl; imidazolinyl; pyrrazolinyl; pyrrolyl; imidazolyl; pyrazolyl; triazolyl; pyridinyl; pyridazinyl; pyrimidinyl; pyrazinyl; triazinyl; azepyl; di-azepyl; morpholinyl; thiomorpholinyl; furyl; thienyl; oxazolyl; isoxazolyl; thiazolyl; thiadiazolyl; isothiazolyl; dioxolyl; dithianyl; tetrahydrofuryl; tetrahydropyranyl; and oxadiazolyl; each Het optionally substituted with 1, 2 or 3 substituents, each independently from each other selected from the group of halo, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio, formyl, C 1-3 alkyl, and C 1-3 alkyloxy; and halo is fluoro, chloro, bromo or iodo.