Patent ID: 7427631

Claim:
A compound of the formula I or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof wherein X is selected from NR1; Y1 and Y2 are independently selected from O, S; Z is selected from SO, SO 2 ; m is 1; A is a direct bond; R1 is selected from H, (C1-3)alkyl, or haloalkyl; R2 is: (i) H; or (ii) alkyl, which is optionally substituted with one or more groups independently selected from cyano, amino, N-alkylamino, N,N-dialkylamino, amido, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, in which the aryl or heteroaryl is optionally further substituted with one or more groups independently selected from alkyl, halo, amino, N-alkylamino, N,N-dialkylamino, amido, or alkylsulfonylamino; or (iii) cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, in which the aryl or heteroaryl is optionally substituted with one or more groups independently selected from alkyl, halo, amino, N-alkylamino, N,N-dialkylamino, amido, or alkylsulfonylamino; Each of R3 and R4 is independently selected from H or (C1-3)alkyl; R5 is a bicyclic group of the following formula: wherein G1 is pyridyl, optionally substituted by one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, alkylsulfonamino, alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, haloalkylsulfonyl, alkylaminosulfonyl, carboxylate, alkylcarboxylate, aminocarboxy, N-alkylamino-carboxy, N,N-dialkylamino-carboxy, wherein any alkyl radical within any substituent may itself be optionally substituted with one or more groups selected from halogen, hydroxy, alkoxy, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, N-alkylsulfonamino, N-alkylcarboxyamino, cyano, nitro, thiol, alkylthiol, alkylsulfonyl, N-alkylaminosulfonyl, carboxylate, alkylcarboxy, aminocarboxy, N-alkylaminocarboxy, N,N-dialkylaminocarboxy, carbonate; B is a direct bond or —O—; and G2 is: