Patent ID: 8461111

Claim:
A method of treating a wound comprising: (a) identifying an individual having a wound, and (b) administering to the individual a composition comprising a therapeutically effective amount of a mutant fibroblast growth factor (FGF) protein, wherein the mutant FGF triggers angiogenesis and proliferation of fibroblasts involved in healing damaged tissue, wherein the mutant FGF protein is a mutant FGF protein having a polypeptide sequence that is at least 90% identical to the polypeptide sequence of wild-type human FGF-1 protein (SEQ ID NO: 1), wherein the alanine (Ala) at an amino acid position of the mutant FGF protein corresponding to amino acid position 66 of wild-type human FGF-1 is replaced with cysteine (Cys), and wherein the numbering of the amino acid positions is based on the numbering scheme for the 140 amino acid form of human FGF-1.