Patent ID: 8212029

Claim:
A process for producing 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine and its derivatives with formulas I and II: or salts thereof, wherein, R 1 is selected from the group consisting of: hydrogen, hydroxy, alkoxy, low alkyl, low alkyl substituted by at least one halogen, low alkenyl, low alkinyl, aryl, aralkyl, aryloxyalkyl, formyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, alkylsulfonyl, aralkylsulfonyl, and arylsulfonyl, R 2 is selected from the group consisting of: hydrogen, formyl, alkyl, alkenyl, aryl, aralkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, alkylsulfonyl, arylsulfonyl and aralkylsulfonyl, and Z″ is an anion of a pharmaceutically acceptable organic acid or an inorganic anion, said process comprising: reaction step 1, debrominating racemic bromine narwedine with palladium (II) acetate and triphenylphosphine to obtain racemic narwedine, reaction step 2, contacting the racemic narwedine with oxygen and converting the racemic narwedine into an enantiomerically pure narwedine, reaction step 3, reducing the enantiomerically pure narwedine to obtain enantiomerically pure galanthamine of formula (I) with R 1 equal to CH 3 , and reaction step 4, alkylating or dealkylating the galanthamine to obtain compounds of formula (I), or reaction step 4′, alkylating or dealkylating the galanthamine and subsequently forming a salt to obtain compounds of formula (II).