Patent ID: 7517880

Claim:
A compound of formula I B is naphthyl substituted by —Q—Ar and optionally substituted by one or more substituents which is selected from the group consisting of halogen, up to per-halo, and W n , wherein n is 0-2 and each W is independently —CN, —CO 2 R 7 , —C(O)NR 7 R 7 , —C(O)—R 7 , —NO 2 , —OR 7 , —SR 7 , —NR 7 R 7 , —NR 7 C(O)OR 7 , —NR 7 C(O)R 7 , C 1 -C 10 alkyl, C 2-10 -alkenyl, C 1-10 -alkoxy, C 3 -C 10 cycloalkyl, C 6 -C 14 aryl, C 7 -C 24 alkaryl, C 3 -C 13 heteroaryl, C 4 -C 23 alkheteroaryl, substituted C 1 -C 10 alkyl, substituted C 2-10 -alkenyl, substituted C 1-10 -alkoxy, substituted C 3 -C 10 cycloalkyl, substituted C 4 -C 23 alkheteroaryl or Q-Ar; wherein if W is a substituted group, it is substituted by one or more substituents which is independently of —CN, —CO 2 R 7 , —C(O)R 7 , —C(O)NR 7 R 7 , —OR 7 , —SR 7 , —NR 7 R 7 , NO 2 , —NR 7 C(O)R 7 , —NR 7 C(O)OR 7 or halogen up to per-halo; wherein each R 7 is independently H, C 1 -C 10 alkyl, C 2-10 -alkenyl, C 3 -C 10 cycloalkyl, up to per-halosubstituted C 2 -C 10 alkyl, up to per-halosubstituted C 2-10 -alkenyl or up to per-halosubstituted C 3 -C 10 cycloalkyl, wherein Q is —O—, —S—, —N(R 7 )—, —(CH 2 )— m , —C(O)—, —CH(OH)—, —(CH 2 ) m O—, —NR 7 C(O)NR 7 R 7′ —, —NR 7 C(O)—, —C(O)NR 7 —, —(CH 2 ) m S—, —(CH 2 ) m N(R 7 )—, —O(CH 2 ) m —, —CHX a , —CX a 2 —, —S—(CH 2 ) m — or —N(R 7 )(CH 2 ) m —, m=1-3, and X a is halogen; and Ar is a 5-10 member aromatic structure containing 1-2 members of the group consisting of nitrogen, oxygen and sulfur, which is unsubstituted or substituted by halogen up to per-halo and substituted by Z n1 , wherein n1 is 1 to 3 and each Z is independently —CN, —C(O)NR 7 R 7 , —COR 7 , —NR 7 C(O)OR 7 , —NR 7 C(O)R 7 , substituted C 1 -C 10 alkyl or substituted C 3 -C 10 cycloalkyl wherein the one or more substituents of the substituted C 1 -C 10 alkyl and substituted C 1 -C 10 cycloalkyl is are —CN, —C(O)NR 7 R 7 , —NR 7 C(O)R 7 or —NR 7 C(O)OR 7 , R 3′ , R 4′ , R 5′ are each independently H, C 1 -C 10 -alkyl, optionally substituted by halogen, up to perhalo, C 1-10 alkoxy, optionally substituted by halogen, up to perhaloalkoxy, halogen; NO 2 or NH 2 ; R 6′ is H, C 1-10 -alkyl, C 1-10 alkoxy, —NHCOR 1 ; —NR 1 COR 1 ; or NO 2 ; one of R 4′ , R 5′ or R 6′ can be -X-Y, or 2 adjacent R 4′ , R 5′ , or R 6′ can together be an aryl or hetaryl ring with 5-12 atoms, optionally substituted by C 1-10 -alkyl, C 1-10 alkoxy, C 3-10 cycloalkyl, C 2-10 alkenyl, C 1-10 alkanoyl, C 6-12 aryl, C 5-12 hetaryl or C 6-12 aralkyl; R 1 is C 1-10 -alkyl optionally substituted by halogen, up to perhalo; X is —CH 2 —, —S—, —N(CH 3 )—, —NHC(O)—, —CH 2 —S—, —S—CH 2 —, —C(O)—, or —O—; and X is additionally a single bond where Y is pyridyl; Y is phenyl, pyridyl, naphthyl, pyridone, pyrazine, benzodioxane, benzopyridine, pyrimidine or benzothiazole, each optionally substituted by C 1-10 -alkyl, C 1-10 -alkoxy, halogen, OH, —SCH 3 or NO 2 or, where Y is phenyl, by or a pharmaceutically acceptable salt thereof.