Patent ID: 7498025

Claim:
A method for directing the biodistribution of a drug that binds to a protein target, wherein the drug is directed to an intracellular space upon administration to a mammalian host, said method comprising: administering to said mammalian host an effective amount of a bifunctional molecule having a molecular weight that does not exceed about 5000 daltons consisting of a drug moiety comprising said drug or an active derivative thereof and a targeting moiety to an intracellular biodistribution modulating protein optionally joined by a linking group, wherein said drug moiety binds to a naturally occurring protein target and said targeting moiety is a peptidyl-prolyl isomerase ligand, and wherein said bifunctional molecule has a modulated biodistribution upon administration to said mammalian host as compared to a free drug control; to direct said biodistribution of said drug upon administration to said host to an intracellular space as compared to a free drug control.