Patent ID: 8128920

Claim:
A method of treating acute disseminated encephalomyelitis (ADEM), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), Guillain-Barré syndrome (GBS), peripheral neuropathy, traumatic nerve injury, traumatic brain injury or amyotrophic lateral sclerosis (ALS) comprising administering a composition comprising an IL-18 binding protein (IL-18BP) isoform to an individual having a disease selected from acute disseminated encephalomyelitis (ADEM), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), Guillain-Barré syndrome (GBS), peripheral neuropathy, traumatic nerve injury, traumatic brain injury or amyotrophic lateral sclerosis (ALS), wherein said composition is administered in an amount effective to treat said disease and said IL-18BP isoform is selected from the group consisting of: (a) polypeptide comprising amino acids 1 to 113 of SEQ ID NO: 1; (b) a polypeptide comprising amino acids 29 to 113 of SEQ ID NO: 1; (c) a polypeptide comprising amino acids 78 to 113 of SEQ ID NO: 1; (d) a polypeptide comprising amino acids 1 to 161 of SEQ ID NO: 2; (e) a polypeptide comprising amino acids 29 to 161 of SEQ ID NO: 2; and (f) a fusion protein comprising a polypeptide according to any one of (a)-(e).