Patent ID: 8481563

Claim:
A method of treating a mammal having a medical condition ameliorated by treatment with a mu opioid receptor antagonist, wherein the medical condition is opioid-induced bowel dysfunction or post-operative ileus, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: R 7 is hydrogen or —CH 2 —R 1 ; R 1 is C 4-10 alkyl, C 3-12 cycloalkyl, or phenyl, wherein C 3-12 cycloalkyl and phenyl are each optionally substituted with one or two halo; R 2 is selected from —C(O)R 3 , —C(O)NHR 4 , —C(O)OR 5 , —S(O) 2 R 6 , and —C(O)R 8 ; R 3 is C 1-6 alkyl substituted with one or two substituents selected from —OR a , —S(O) 2 R b , and —C(O)R c ; R 4 and R 5 are each independently C 1-6 alkyl substituted with one or two substituents selected from —OR a and —S(O) 2 R b ; R 6 is C 1-3 alkyl; R 8 is phenyl, optionally substituted with one or two halo; R a is hydrogen or C 1-3 alkyl; R b is C 1-3 alkyl; R c is selected from hydrogen, C 1-3 alkyl, and benzyl; and m is 1 or 2; provided that when R 7 is hydrogen, R 2 is —C(O)R 8 ; or a pharmaceutically-acceptable salt thereof.