Patent ID: 7611481

Claim:
A microprotrusion transdermal delivery device, comprising: an ingredient-containing reservoir defining a perimeter; a backing member overlying the ingredient containing reservoir, said backing member being made of a material which is substantially impermeable to ingredients contained in the reservoir; a cover for the reservoir, the cover being made of a material substantially impermeable to ingredients contained in the reservoir, but having at least one opening defining a perimeter, such that ingredients to be delivered from the reservoir will flow through the opening, but will not readily flow through the material of which the cover is made; a first seal sealing the cover to the backing member at the perimeter of the reservoir wherein the first seal which is not subject to permeation, disintegration or degradation by any ingredient contained in the reservoir; an adhesive layer adhered to the backing member for adhering the device to a patient's skin or mucosa, the adhesive layer not extending to the perimeter of the opening in the cover, such that a portion of the cover surrounding the perimeter of the opening is exposed to thereby define a cover sealing surface; a microprotrusion layer at least partially adhered to the adhesive layer, the microprotrusion layer including at least one opening therethrough generally aligned with the opening in the cover, such that ingredients to be delivered from the reservoir flow through the opening in the microprotrusion layer, wherein the microprotrusion layer pierces at least a portion of the skin or mucosa when the device is applied to a subject's skin or mucosa; a second seal; a liner covering the cover sealing surface and the opening in the cover, the liner being releasably sealed to the cover sealing surface by the second seal, wherein the second seal is not subject to permeation, disintegration or degradation by any ingredient in the reservoir; whereby ingredients contained in the reservoir are sealed therein during storage and non-use by the first and second seals, but are free to flow through the openings in the microprotrusion layer and the cover and onto a subject's skin or mucosa when the liner is removed from the device and the device is applied to skin or mucosa.