Patent ID: 7691877

Claim:
A compound of formula (I) or a tautomer thereof, wherein: (a) Y is a direct bond, and R 3 is selected from aryl, and —(C 1 -C 4 )alkylene-O—(C 1 -C 4 )alkyl; or (b) Y is (C 1 -C 4 )alkylene, and R 3 is selected from aryl, (C 3 -C 7 )cycloalkyl and a 3 to 10-membered heterocyclyl; Z is an oxygen or is absent; R 1 is selected from H, halo, OH, CN, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )alkoxy, —NHSO 2 R 6 , —NR 6 R 7 , —C(O)R 6 , —CO 2 R 6 , —C(O)NR 6 R 7 , —C(O)NR 6 SO 2 R 8 , aryl and 3 to 10-membered heterocyclyl; R 2 is selected from H, halo, OH, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )alkoxy, —NR 6 R 7 , —CO 2 R 6 , —C(O)NR 6 R 7 , —C(O)NR 6 SO 2 R 8 , and 3 to 10-membered heterocyclyl; or R 1 and R 2 may be joined to form a (C 2 -C 5 )alkylene link, said link optionally incorporating 1 or 2 heteroatoms each independently selected from N, O and S; R 5 is absent and R 4 is selected from H, (C 3 -C 7 )cycloalkyl, aryl, —(CH 2 )aryl, —C(O)R 9 , —CO 2 R 9 , —(C 1 -C 6 )alkylene-O—C(O)R 9 , —(C 1 -C 6 )alkylene-O—CO 2 R 9 ), —C(O)NR 9 R 10 , —(C 1 -C 6 )alkylene-O—C(O)NR 9 R 10 and —(C 1 -C 6 )alkylene-O—P(O)(OH) 2 ; or R 4 is absent and R 5 is selected from R 9 , —C(O)R 9 , —CO 2 R 9 , —(C 1 -C 6 )alkylene-O—C(O)R 9 , —(C 1 -C 6 )alkylene-O—CO 2 R 9 , —C(O)NR 9 R 10 , —(C 1 -C 6 )alkylene-O—C(O)NR 9 R 10 and —(C 1 -C 6 )alkylene-O—P(O)(OH) 2 ; R 6 and R 7 are each independently selected from H, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, and —(C 1 -C 6 )alkylene(C 3 -C 7 )cycloalkyl; or R 6 and R 7 taken together with the nitrogen to which they are attached form a 3 to 6 membered saturated heterocycle optionally containing a further one or two heteroatoms selected from N, O and S; R 8 is selected from (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl and phenyl; R 9 and R 10 are each independently selected from H, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, aryl, —(CH 2 )aryl and 3 to 10-membered heterocyclyl; or R 9 and R 10 , taken together with the nitrogen to which they are attached, form a 3 to 10-membered heterocyclyl group; and R 11 and R 12 are independently selected from H and (C 1 -C 6 )alkyl; or R 11 and R 12 together with the N to which they are attached form a 3 to 6 membered saturated heterocyclyl optionally containing a further one or two heteroatoms selected from N, O and S; wherein said alkyl, cycloalkyl, alkoxy, aryl and heterocyclyl groups being optionally substituted by one or more atoms or groups independently selected from halo, OH, oxo, CF 3 , CN, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )alkoxy, —(C 1 -C 6 )alkylene-O—(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene-OH, —NR 11 R 12 , —(C 1 -C 6 )alkylene-NR 11 R 12 , aryl and 3 to 10-membered heterocyclyl; or a pharmaceutically acceptable salt thereof.