Patent ID: 8283137

Claim:
A process for preparing a recombinant fibrinogen-producing cell which produces a high level of fibrinogen of 100 μg/ml or more, comprising transfecting, into an animal cell, genes encoding (i) an α chain and/or an αE variant thereof, (ii) a β chain, and (iii) a γ chain and/or a γ′ variant thereof which are polypeptides constituting fibrinogen, wherein the number of genes encoding a γ chain and/or a γ′ variant thereof is 1 to 3 times the sum of the number of genes encoding an α chain and/or an αE variant thereof and the number of genes encoding a β chain, wherein the animal cell transfected with the genes encoding the chains produces a high level of fibrinogen of 100 μg/ml or more.