Patent ID: 7247467

Claim:
A mutant replication control region having a nucleotide sequence as set forth in nucleotides 2478–3765 of SEQ ID NO:1 and having one point mutation independently selected from the group consisting of: a) a mutation of G to A at nucleotide 2490; b) a mutation of C to Tat nucleotide 2496; c) a mutation of T to C at nucleotide 2579; d) a mutation by deletion of C at nucleotide 2633; e) a mutation by deletion of C at nucleotide 2634; f) a mutation of T to C at nucleotide 2663; g) a mutation of A to G at nucleotide 2771; h) a mutation of T to C at nucleotide 2805; i) a mutation of C to A at nucleotide 2838; j) a mutation of T to C at nucleotide 2914; k) a mutation of T to C at nucleotide 2935; l) a mutation of C to T at nucleotide 3003; m) a mutation for substitution of G to A at nucleotide 3165; n) a mutation of T to G at nucleotide 3262; o) a mutation of C to T at nucleotide 3269; p) a mutation of T to C at nucleotide 3344; q) a mutation of C to T at nucleotide 3347; r) a mutation for substitution of C to A at nucleotide 3456; s) a mutation for substitution of T to C at nucleotide 3468; t) a mutation for substitution of A to G at nucleotide 3570; u) a mutation of T to C at nucleotide 3604; v) a mutation of A to C at nucleotide 3641; w) a mutation of A to G at nucleotide 3729; x) a mutation of T to A at nucleotide 3739; and y) a mutation of T to C at nucleotide 3747.