Patent ID: 8282934

Claim:
A method of treating a cancer comprising: a) obtaining a cytokine-antibody DNL complex comprising; i) a cytokine moiety attached to a DDD (dimerization and docking domain) moiety, wherein the amino acid sequence of said DDD moiety is selected from the group consisting of SEQ ID NO:10 and SEQ ID NO:12 and wherein the cytokine is selected from the group consisting of interferon (IFN)-α2b, G-CSF, GM-CSF and erythropoietin; ii) an antibody moiety attached to an AD (anchor domain) moiety, wherein the antibody moiety binds to a tumor associated antigen (TAA), wherein the amino acid sequence of the AD moiety is selected from the grou I consisting of SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22 and SEQ ID NO:23 and wherein two copies of the DDD moiety form a dimer that binds to the AD moiety to form the complex; and b) administering the complex to a human subject with the cancer.