Patent ID: 7695735

Claim:
Improved multiparticulate tablet which disintegrates in contact with the saliva in the mouth in less than 40 seconds, consisting of particles of coated active substance, and mixture of excipients being free of effervescent agents, the ratio of excipient mixture to coated active substance particles being 0.4 to 6 parts by weight, the mixture of excipients consisting of: 1 to 15% by weight based on the weight of the tablet of a disintegration agent selected from the group consisting of croscarmellose, crospovidone and mixtures thereof; 30 to 90% by weight, based on the weight of the tablet of a soluble diluent agent with binding properties which consists of a directly compressible polyol selected from the group consisting of mannitol, xylitol and, with an average particle diameter of 100 to 500 μm; 0.05 to 2% by weight based on the weight of the tablet of a lubricant selected from the group consisting of magnesium stearate, sodium stearyl fumarate, stearic acid, micronized polyoxyethylene glycol and mixtures thereof; at least one from the group consisting of sweeteners, flavorings, colors and mixtures thereof; and 0.5 to 5% by weight based on the weight of the tablet of a permeabilizing agent selected from the group consisting of precipitated silicas with a high affinity for aqueous solvents, maltodextrins, β-cyclodextrines and mixtures thereof, in an amount sufficient to create a hydrophilic network which facilitates the penetration of the saliva.