Patent ID: 8785594

Claim:
A method for the preparation of a carbohydrate-peptide conjugate, said method comprising: reacting a cyclic carbamate (1) with a peptide, wherein R 3 and R 4 are independently selected from the group consisting of hydroxyl, acetamido, and a carbohydrate moiety, R 5 is selected from the group consisting of hydrogen, methyl, hydroxymethyl, acetamidomethyl, carboxyl, and X—(CH 2 ) r —, wherein X is a carbohydrate moiety and r is an integer selected from 0, 1, 2 and 3, and said peptide includes at least one primary amino group, and said peptide is a cell surface or cell membrane bound protein, and said carbohydrate-peptide conjugate includes at least one moiety selected from the group consisting of General Formulae 1 and 2 wherein, in General Formula 1, R 1 and R 2 together with the intervening lysine moiety represent a cell surface or cell membrane bound protein; R 3 , R 4 and R 5 are as defined at cyclic carbamate (1), and pharmaceutically acceptable salts thereof, and wherein, in General Formula 2, R 11 is an amino acid side chain; R 12 together with —NH—CHR 11 —C(═O)— represents a cell surface or cell membrane bound protein, R 3 , R 4 and R 5 are as defined at cyclic carbamate (1), and pharmaceutically acceptable salts thereof.