Patent ID: 8921412

Claim:
A compound of formula I, or a pharmaceutically acceptable salt or a prodrug thereof: wherein, X is methylene or cyclopropane; ring A is benzene, naphthalene, or indole; ring B is said ring D being C 3-10 cycloalkyl, C 5-10 cycloalkenyl, C 6-14 aryl, 5 to 13-membered heteroaryl, or 5 to 10-membered heterocycloalkyl; ring C is a macrocycle formed by connecting ansa bridge between the tetrahydropyran ring and ring A; and n is an integer of 5 to 10, wherein, said ring A and ring B are each independently optionally substituted with at least one selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, cyano, nitro, amino, carboxy, C 1-7 alkyl, C 2-7 alkenyl, C 2-7 alkynyl, hydroxy-C 1-7 alkyl, C 1-7 alkoxy, C 1-7 alkoxy-C 1-7 alkyl, C 2-7 alkenyl-C 1-7 alkyloxy, C 2-7 alkynyl-C 1-7 alkyloxy, C 3-10 cycloalkyl, C 5-10 cycloalkenyl, C 3-10 cycloalkyloxy, phenyl-C 1-7 alkoxy, mono- or di-C 1-7 alkylamino, C 1-7 alkanoyl, C 1-7 alkanoylamino, C 1-7 alkoxycarbonyl, carbamoyl, mono- or di-C 1-7 alkylcarbamoyl, C 1-7 alkylsulfonylamino, phenylsulfonylamino, C 1-7 alkylsulfanyl, C 1-7 alkylsulfinyl, C 1-7 alkylsulfonyl, C 6-14 arylsulfanyl, C 6-14 arylsulfonyl, C 6-14 aryl, 5 to 13-membered heteroaryl, and 5 to 10-membered heterocycloalkyl; said R 5a , R 5b , R 6a , and R 6b are each independently selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, cyano, nitro, amino, carboxy, C 1-7 alkyl, C 2-7 alkenyl, C 2-7 alkynyl, hydroxy-C 1-7 alkyl, C 1-7 alkoxy, C 1-7 alkoxy-C 1-7 alkyl, C 2-7 alkenyl-C 1-7 alkyloxy, C 2-7 alkynyl-C 1-7 alkyloxy, C 3-10 cycloalkyl, C 5-10 cycloalkenyl, C 3-10 cycloalkyloxy, phenyl-C 1-7 alkoxy, mono- or di-C 1-7 alkylamino, C 1-7 alkanoyl, C 1-7 alkanoylamino, C 1-7 alkoxycarbonyl, carbamoyl, mono- or di-C 1-7 alkylcarbamoyl, C 1-7 alkylsulfonylamino, phenylsulfonylamino, C 1-7 alkylsulfanyl, C 1-7 alkylsulfinyl, C 1-7 alkylsulfonyl, C 6-14 arylsulfanyl, C 6-14 arylsulfonyl, C 6-14 aryl, 5 to 13-membered heteroaryl, and 5 to 10-membered heterocycloalkyl; said alkyl, alkenyl, alkynyl, or alkoxy is optionally substituted with at least one selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C 1-7 alkyl, and C 2-7 alkynyl; and said cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocycloalkyl is optionally substituted with at least one selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C 1-4 alkyl, and C 1-4 alkoxy.