Patent ID: 8637537

Claim:
A compound according to formula I wherein: A is A-1 or A-2; Z is N or CR 2 ; R 1a and R 1b are (i) each independently hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl or C 1-3 alkoxy-C 1-6 alkyl, or, (ii) R 1a and R 1b together are (CH 2 ) 2-5 ; R 2 is hydrogen, C 1-6 alkyl, C 1-6 alkoxy or C 3-6 cycloalkyl; R a is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-3 alkoxy-C 1-6 alkyl, C 4-7 cycloalkyl, pyrrolidinyl, piperidinyl or R c R d N[C(R 10 ) 2 ] 2-6 ; R b is hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R c and R d are independently (i) hydrogen or C 1-6 alkyl or (ii) R c and R d together with the nitrogen to which they are attached are a pyrrolidine and piperidine ring; R 3 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, halogen, C 1-6 acyl or C 1-3 haloalkanoyl; R 4 is independently in each occurrence hydroxy, thiol, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, halogen, C 1-6 alkoxycarbonyl, carboxyl, C 1-6 alkylthio, C 1-6 hydroxyalkyl, nitro, amino, C 1-3 alkylamino, C 1-3 dialkylamino, amino-C 1-3 alkyl, C 1-3 alkylamino-C 1-3 alkyl, C 1-3 dialkylamino C 1-3 alkyl, C 1-6 alkylsulfonyl, arylsulfonyl, C 1-6 alkylaminosulfonyl, arylaminosulfonyl, C 1-6 alkylsulfonylamido, arylsulfonylamido, carbamoyl, C 1-3 alkylcarbamoyl and C 1-3 dialkylcarbamoyl, arylcarbamoyl, C 1-6 alkylcarbonylamino, arylcarbonylamino; n is zero, one, two or three; R 5 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-3 alkoxy-C 1-6 alkyl, cyano or OR 9 ; R 6 is hydrogen, halogen, C 1-6 alkyl, C 1-6 haloalkyl, cyano, C 1-6 hydroxyalkyl or C 1-3 alkoxy-C 1-6 alkyl; R 7 is selected from the group consisting of (i) C 1-10 alkyl, (ii) C 1-10 haloalkyl, (iii) optionally substituted C 3-7 cycloalkyl (iv) C 3-7 cycloalkyl-C 1-6 alkyl, (v))R 9 O[C(R 10 ) 2 ] 0-6 , (vi) C 3-7 heterocyclyl and (vii) C 3-7 heterocyclyl-C 1-6 alkyl (viii) C 1-6 cyanoalkyl; R 9 is independently in each occurrence C 1-10 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, phenyl-C 1-6 alkyl, pyridinyl-C 1-6 alkyl, pyridinyl or phenyl; R 10 is independently in each occurrence hydrogen or C 1-6 alkyl; said cycloalkyl in each occurrence is independently optionally substituted with C 1-6 alkyl, halogen or optionally substituted phenyl; said phenyl in each occurrence is independently optionally substituted with C 1-6 alkyl, halogen or C 1-6 alkoxy; said heterocyclyl is independently substituted with halogen or C 1-6 alkyl; or, a pharmaceutically acceptable salt thereof.