Patent ID: 7528282

Claim:
A compound of formula (I), wherein one of A 1 , A 2 , A 3 and A 4 is —CO 2 R 17 and —C(O)—N(R 18 R 19 ) and the remaining members of the group consisting of A 1 , A 2 , A 3 and A 4 are each individually selected from the group consisting of hydrogen, and alkyl; D is a bond; E is aryl; R 1 is selected from the group consisting of hydrogen and alkyl; R 2 is selected from the group consisting of hydrogen, alkyl and cycloalkyl; R 3 and R 4 are each independently selected from the group consisting of hydrogen, alkyl, carboxyalkyl, carboxycycloalkyl, cycloalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle and heterocyclealkyl, or R 3 and R 4 together with the atom to which they are attached form a ring selected from the group consisting of cycloalkyl and heterocycle; R 17 is selected from the group consisting of hydrogen, alkyl, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, heteroaryl, heteroarylalkyl, heteroaryloxyalkyl, heterocycle, heterocyclealkyl and heterocycleoxyalkyl; R 18 and R 19 are each independently selected from the group consisting of hydrogen, alkoxy, alkyl, alkylsufonyl, carboxy, carboxyalkyl, carboxycycloalkyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfonyl, aryl, arylalkyl, aryloxy, aryloxyalkyl, alylsulfonyl, heteroaryl, heteroarylalkyl, heteroaryloxyalkyl, heteroarylsulfonyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, heterocycleoxy, heterocyclesulfonyl and hydroxy, or R 18 and R 19 together with the atom to which they are attached form a heterocycle; or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof.