Patent ID: 7960427

Claim:
A compound of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts thereof: wherein: R 1 is H, C 1 -C 6 alkyl, or C 3 -C 7 cycloalkyl, wherein said alkyl and cycloalkyl are optionally substituted with 1 to 2 substituents selected from the group consisting of hydroxyl, nitro, halo, cyano, trifluoromethyl and trifluoromethoxy; R 2 is C 1 -C 6 alkyl, wherein the alkyl is optionally substituted with 1 to 2 substituents selected from the group consisting of hydroxyl, nitro, halo, cyano, trifluoromethyl and trifluoromethoxy; X is H, nitro, halo, cyano, trifluoromethyl or trifluoromethoxy; Y is —NR 3 R 4 ; Z is or wherein p represents an integer from 0 to 4, q represents the integer 0 or 1, and when p represents the integer 0, q represents the integer 0; R 3 and R 4 are covalently bonded together with the nitrogen to which they are attached to form guanidyl, 5- to 10-membered heterocyclic radical or 5- to 10-membered heteroaryl radical, wherein except for the nitrogen atom to which R 3 and R 4 are attached, said heterocyclic and heteraryl radicals may have optionally 1 to 4 heteroatoms selected from N, O or S, and wherein except for the nitrogen atom to which R 3 and R 4 are attached, said heterocyclic radical may optionally have 1 to 2 carbon-carbon double bond or triple bond, said heterocyclic and heteroaryl radicals can be optionally substituted with 1 to 3 same or different R 8 ; Ar 2 represents C 6 -C 10 aryl, 5- to 10-membered heteroaryl radical or 5- to 10-membered heterocyclic radical, wherein said heteroaryl and heterocyclic radicals can have 1 to 3 heteroatoms selected from N, O or S and Ar 2 can be optionally substituted with 1 to 3 same or different R 9 ; R 8 represents C 1 -C 4 alkyl, C 1 -C 4 alkoxyl, halo, hydroxyl, cyano, carboxyl, ester group or nitro; and R 9 represents C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, hydroxyl, C 1 -C 6 alkyl or C 1 -C 6 alkoxyl which is optionally substituted with hydroxyl, amino or halo, C 1 -C 6 alkylsulfanyl, carboxyl group which can be free or form ester group, amide, or salts, halo, C 1 -C 6 alkylacyl, nitro, cyano, amino, C 1 -C 6 alkylamide group, or amine group substituted with (C 1 -C 6 alkyl) n , where n is 1 or 2.