Patent ID: 8466182

Claim:
A method for inhibiting activity of kynurenine-3-monooxygenase which method comprises contacting a cell in need of inhibition of kynurenine-3-monooxygenase activity with an effective amount of one or more compounds of Formula II: wherein: T and W independently are selected from the group consisting of N, NR 3 , S, S(O), S(O) 2 , O, and CR 3 and U is selected from the group consisting of N, NR 3 , S, S(O), S(O) 2 , and O with the proviso that no more than one of T, U, and W are S, S(O), S(O) 2 , and O; R 1 and R 2 independently are selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, substituted amino, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, cyano, halo, hydroxyl, acyl, nitro, mercapto, alkylthio, substituted alkylthio, substituted sulfonyl, substituted sulfonyloxy, substituted sulfinyl, and aminocarbonyl, or R 1 and R 2 join together to form a ring selected from the group consisting of C 5 -C 7 cycloalkyl, substituted C 5 -C 7 cycloalkyl, C 5 -C 7 heterocycloalkyl, substituted C 5 -C 7 heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, halo, amino, substituted amino, alkylthio, substituted alkylthio, substituted sulfonyl, substituted sulfinyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 4 and R 5 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, substituted amino, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, cyano, halo, hydroxyl, acyl, nitro, mercapto, alkylthio, substituted alkylthio, substituted sulfonyl, substituted sulfonyloxy, substituted sulfinyl, and aminocarbonyl, or R 4 and R 5 join together to form a ring selected from the group consisting of C 5 -C 7 cycloalkyl, substituted C 5 -C 7 cycloalkyl, C 5 -C 7 heterocycloalkyl, substituted C 5 -C 7 heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; and R 6 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or its tautomer and/or a pharmaceutically acceptable salt thereof, with the proviso that the ring comprising U, W, and T is not 1,3-thiazol-2-yl.