Patent ID: 7767673

Claim:
A compound represented by Formula (I) wherein: R1 is selected from —NR 3 R 31 , —NR 3 C(O)R 31 , —NR 3 C(O)OR 31 , —NR 3 SO 2 R 31 , —OR 3 , —SR 3 , —SO 2 R 3 , —CO 2 R 3 , —CO 2 H, —CO—NR 3 R 31 , —N(C 0-8 alkyl)(C 0-8 alkyl), or —CN; except when m>1, then R1 is selected from halogen, —CN, NO 2 , —C 0-8 alkyl, —N(C 0-8 alkyl)(C 0-8 alkyl), C 2-8 alkenyl, C 2-8 alkynyl, —NR 3 R 31 , —NR 3 C(O)R 31 , —NR 3 C(O)OR 31 , —NR 3 SO 2 R 31 , —OR 3 , —SR 3 , —SO 2 R 3 , —CO 2 R 3 , —CO 2 H, —CO—NR 3 R 31 , cyclyl, or heterocyclyl; R2 is selected from H, —C 0-8 alkyl, or —C 3-10 cycloalkyl; X is a cyclyl or heterocyclyl group optionally substituted with one or more substituents selected from halogen, —NR 32 R 33 , —NR 32 COR 33 , —NR 32 CO 2 R 33 , —NR 32 SO 2 R 33 , —OR 32 , —SR 32 , —SO 2 R 32 , —SO 2 NR 32 R 33 , —CO 2 R 32 , —CO 2 H, —CONR 32 R 33 , —C 0-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, —CN, —CF 3 , —OCF 3 , —NO 2 , oxo, cyclyl, or heterocyclyl; Y is selected from one of: wherein the point of attachment of Y to X can be from either the left or the right of the linkers as shown above; R a and R b each independently is —C 0-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, —C 3-10 cycloalkyl, —C 3-10 cycloalkenyl, —C 1-8 alkoxy, -thioC 1-8 alkyl, carboxyl, —N(C 0-8 alkyl)(C 0-8 alkyl), oxo, or hydroxy; or taken together with the C to which they are attached, form a saturated or partially unsaturated 3-10 membered ring optionally containing 0-4 N, O, S, SO, or SO 2 at the ring nodes; R c and R d each independently is —C 0-8 alkyl, —C 2-8 alkenyl, benzyl, or acyl; or taken together, or with R a or R b , form a 3-7 membered saturated or partially unsaturated ring; m is 0, 1, 2, 3, 4, or 5; Z is a cyclyl or heterocyclyl group, optionally substituted with one or more substituents selected from halogen, —NR 34 R 35 , —NR 34 COR 35 , —NR 34 CO2R 35 , —NR 34 SO 2 R 35 , —OR 34 , —SR 34 , —SO 2 R 34 , —SO 2 NR 34 R 35 , —CO 2 R 34 , —CO 2 H, —CONR 34 R 35 , —C 0-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, —CN, —CF 3 , —NO 2 , oxo, cyclyl, heterocyclyl, —C 1-8 alkyl, or —C 1-8 alkyl-O—C 1-8 alkyl; and R 3 , R 31 , R 32 , R 33 , R 34 and R 35 are independently (a) C 0-8 alkyl optionally substituted with heterocyclyl or OH; (b) —C 0-8 alkyl-C 3-8 cycloalkyl, CF 3 , —C 0-8 alkyl-O—C 0-8 alkyl, —C 0-8 alkyl-N(C 0-8 alkyl)(C 0-8 alkyl), —C 0-8 alkyl-S(O) 0-2 —C 0-8 alkyl; or (c) heterocyclyl optionally substituted with —C 0-8 alkyl, cyclyl, or substituted cyclyl; or a pharmaceutically acceptable salt or N-oxide thereof.