Patent ID: 7829085

Claim:
A method of treatment of a thrombotic pathological condition involving Factor VIII in a mammal, wherein, in said condition, the risk of clot formation is increased, said method comprising administering to said mammal in need of such treatment a therapeutically effective amount of a composition comprising an antibody directed against the C1 domain of Factor VIII or an antigen binding fragment of said antibody, wherein said antibody is a partially inhibitory antibody of Factor VIII, said antibody comprising a variable heavy chain sequence of which the sequence of the CDR1, CDR2, and CDR3 correspond to the sequence of SEQ ID NO: 33, 34, and 35, respectively and comprising a variable light chain sequence of which the sequence of the CDR1, CDR2, and CDR3 correspond to the sequence of SEQ ID NO: 36, 37, and 38, respectively.