Patent ID: 8067613

Claim:
A compound of Formula I or a salt thereof, wherein A 1 is heteroaryl which is substituted with A 2 and unfused; A 2 is B 1 is hydrogen or R 3 ; R 3 is alkyl; C 1 , D 1 , E 1 are each independently hydrogen, NO 2 , CN, R 5 , OR 5 , CO(O)R 5 , C(O)NH 2 , C(O)NHR 5 , C(O)N(R 5 ) 2 , NH 2 , NHR 5 , N(R 5 ) 2 , OH F, Cl, Br or I; R 5 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two substituents independently selected from R 6 , NH 2 , NHR 6 , N(R 6 ) 2 , C(O)NH 2 , C(O)NHR 6 , C(O)N(R 6 ) 2 , OH, F, Cl, Br and I; R 6 is alkyl or cycloalkyl; wherein each foregoing cyclic moiety is independently unsubstituted or substituted with one or two or three or four or five substituents independently selected from R 7 , OR 7 , SR 7 , S(O)R 7 , SO 2 R 7 , C(O)R 7 , CO(O)R 7 , OC(O)R 7 , OC(O)OR 7 , NO 2 , NH 2 , NHR 7 , N(R 7 ) 2 , CH 2 R 7 , C(O)NH 2 , C(O)NHR 7 , C(O)N(R 7 ) 2 , C(O)NHOH, C(O)NHOR 7 , C(O)NHSO 2 R 7 , C(O)NR 7 SO 2 R 7 , SO 2 NH 2 , SO 2 NHR 7 , SO 2 N(R 7 ) 2 , CF 3 , CF 2 CF 3 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 7 , C(N)N(R 7 ) 2 , CNOH, CNOCH 3 , OH, (O), N 3 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br and I; R 7 is R 8 , R 9 , R 10 or R 11 ; R 8 is phenyl each of which is unfused or fused with benzene, heteroarene or R 8A ; R 8A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 9 is heteroaryl which is unfused or fused with benzene, heteroarene or R 9A ; R 9A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 10 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 10A ; R 10A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 11 is alkyl, alkenyl, or alkenyl, each of which is unsubstituted or substituted with one, two, three, four or five substituents independently selected from R 12 , OR 12 , SR 12 , S(O)R 12 , SO 2 R 12 , NH 2 , NHR 12 , N(R 12 ) 2 , C(O)R 12 , C(O)NH 2 , C(O)NHR 12 , C(O)N(R 12 ) 2 , NHC(O)R 12 , NR 12 C(O)R 12 , NHSO 2 R 12 , NR 12 SO 2 R 12 , NHC(O)OR 12 , NR 12 C(O)OR 12 , SO 2 NH 2 , SO 2 NHR 12 , SO 2 N(R 12 ) 2 , NHC(O)NH 2 , NHC(O)R 12 NHC(O)N(R 12 ) 2 , NR 12 C(O)N(R 12 ) 2 , OH, (O), C(O)OH, CN, CF 3 , OCF 3 , CF 2 CF 3 , F, Cl, Br and I; R 12 is R 13 , R 14 , R 15 or R 16 ; R 13 is phenyl which is unfused or fused with benzene, heteroarene or R 13A ; R 13A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 14 is heteroaryl which is unfused or fused with benzene, heteroarene or R 14A ; R 14A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 15 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 15A ; R 15A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 16 is alkyl, alkenyl or alkenyl, each of which is unsubstituted or substituted with R 17 ; and R 17 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl or heterocycloalkyl.