Patent ID: 7981409

Claim:
A method for reducing a sign of aging skin in a subject in need thereof, the method comprising a step of applying to the skin, a composition comprising an effective amount of interleukin-1 alpha and a dermatologically acceptable carrier, wherein applying the composition to the skin has an effect selected from the group consisting of: reducing the depth and volume of skin wrinkles; improving skin elasticity; improving skin firmness; improving epidermis plus dermis thickness; improving dermis density; improving dermis collagen; and reducing transepidermal water loss, wherein the content of interleukin-1 alpha in said composition is in the range from 10 −7 to 10 −2 wt. %, and wherein the composition further comprises a buffer at a concentration effective to maintain the pH of the composition at between about 4.0 to about 7.5.