Patent ID: 7888485

Claim:
An isolated antibody or antigen-binding fragment thereof that specifically binds to pleiotrophin (PTN) comprising any one of the following: (a) a monoclonal antibody or antigen-binding fragment thereof produced by hybridoma cell line 3B10 having ATCC deposit designation PTA-11180; (b) an antibody or antigen-binding fragment thereof that binds to an epitope, which is the same as an epitope of the monoclonal antibody or antigen-binding fragment thereof produced by hybridoma cell line 3B10 having ATCC deposit designation PTA-11180; or (c) an antibody that competitively inhibits binding of a PTN polypeptide to an antibody comprising: (i) a light chain CDR1 sequence of SEQ ID NO:10, (ii) a light chain CDR2 sequence of SEQ ID NO:11, (iii) a light chain CDR3 sequence of SEQ ID NO:12, (iv) a heavy chain CDR1 sequence of SEQ ID NO:5, (v) a heavy chain CDR2 sequence of SEQ ID NO:6 and (vi) a heavy chain CDR3 sequence of SEQ ID NO:7.