Patent ID: 8309720

Claim:
A process for the preparation of a compound of formula (I) wherein L 1 is CN; R c is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, —CF 3 , cyclopropyl, and cyclobutyl; R 6 is hydrogen; R 8 is selected from the group consisting of hydrogen and C 1-4 alkyl; Z is selected from the group consisting of N and CH; n is 1 or 2; R 9 , R 10 and R 11 are each independently selected from the group consisting of hydrogen and C 1-4 -alkyl; and pharmaceutically acceptable salts thereof; comprising reacting a compound of formula (V) wherein PG 1 and PG 2 are each independently a nitrogen protecting group, with a compound of formula (VI), wherein LG 1 is a leaving group, in a first organic solvent; and when LG 1 is —OH, in the presence of a coupling agent system; to yield the corresponding compound of formula (VII); de-protecting the compound of formula (VII), to yield the corresponding compound of formula (VIII); and reacting the compound of formula (VIII) with a compound of formula (IX), in a second organic solvent, to yield the corresponding compound of formula (I), wherein X is selected from the group consisting of —N(R 20 ) 2 and —OR 21 ; wherein each R 20 is independently selected from the group consisting of C 1-4 alkyl; alternatively the two R 20 groups are taken together with the nitrogen atom to which they are bound to form a saturated ring structure selected from the group consisting of piperidinyl, pyrrolidinyl and morpholinyl; and wherein R 21 is selected from the group consisting of C 1-4 alkyl and benzyl.