Patent ID: 8709998

Claim:
A compound according to formula (I): X—B 1 —B 2 —B 3 —B 4 -Z (I) wherein: X is a cytotoxic or cytostatic agent; each of B 1 , B 2 , B 3 , and B 4 is, independently for each occurrence, (Doc) m , (Aepa) n , —(C(O)-A1-A2-A3-A4-A5-C(O)) s — or (amino acid) p , provided that at least one of B 1 , B 2 , B 3 , and B 4 is —(C(O)-A1-A2-A3-A4-A5-C(O)) s —, and that at least one of B 1 , B 2 , B 3 , and B 4 is (Doc) m or (Aepa) n wherein at least one of m and n is not 0; each of A1 and A5 is, independently for each occurrence, CR 1 R 2 ; each of R 1 and R 2 is, independently for each occurrence, H, F, Br, Cl, I, C( 1-30 )alkyl, C( 2-30 )alkenyl, substituted C( 1-30 )alkyl, substituted C( 2-30 )alkenyl, SR 3 , S(O)R 4 , or S(O) 2 R 5 , or R 1 and R 2 together can form a C( 3-30 )cycloalkyl, C( 3-30 )heterocycle, or C( 5-30 )aryl ring; each of R 3 , R 4 , and R 5 is, independently for each occurrence, C( 1-30 )alkyl, C( 2-30 )alkenyl, substituted C( 1-30 )alkyl, or substituted C( 2-30 )alkenyl; each of A2, A3 and A4 is, independently for each occurrence, CR 6 R 7 , O, S, (CH 2 ) t or absent; each of R 6 and R 7 is, independently for each occurrence, H, F, Br, Cl, I, C( 1-30 )alkyl, C( 2-30 )alkenyl, substituted C( 1-30 )alkyl, substituted C( 2-30 )alkenyl, SR 3 , S(O)R 4 , or S(O) 2 R 5 ; or R 6 and R 7 together may form a ring system; m is, independently for each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; n is, independently for each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; p is, independently for each occurrence, 0, 1, or 2; s is, independently for each occurrence, 1, 2, 3, 4, or 5; t is, independently for each occurrence, 0, 1, 2, or 3; and Z is selected from the group consisting of somatostatin, a somatostatin analog, luteinizing hormone-releasing hormone (LHRH), an LHRH analog, bombesin, and a bombesin analog; provided that: when X is doxorubicin or a doxorubicin derivative, at least one of m and n is not 0; and when X is paclitaxel or a paclitaxel derivative, then B 1 is (amino acid) p and p is 1 or 2; or a pharmaceutically acceptable salt thereof.