Patent ID: 7247744

Claim:
A process for the preparation of a water-soluble derivative of probucol having the following formula where R 1 and R 2 are the same or different and are -C 1 -C 6 alkyl, -C 3 -C 6 alkenyl or aryl, R 3 , R 4 , R 5 and R 6 are the same or different and are C 1 -C 6 alkyl, Z and Z′ are the same or different and are hydrogen or the groups that are saturated acyl or unsaturated acyl having from 1 to 8 carbon atoms said saturated acyl or unsaturated acyl containing a polar or charged functionality where Z and Z′ can not both be hydrogen by mixing a probucol compound of the formula where R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as previously defined with a carboxylic acid anhydride selected from the group consisting of succinic acid anhydride, glutaric acid anhydride, adipic acid anhydride, suberic acid anhydride, sebacic acid anhydride, azelaic acid anhydride, phthalic acid anhydride or maleic acid anhydride and a prophosphatrane compound of the formula where R, R′ and R″ are the same or different and are hydrogen or C 1 to C 8 alkyl to form a reaction mixture and then separating the water soluble derivative of probucol or the probucol compound from said reaction mixture.