Patent ID: 8293717

Claim:
A method of inhibiting an RNA virus infection in a patient, comprising administering to the patient: (a) a nucleotide sequence encoding at least one enzymatically active fragment of a 2′-5′ oligoadenylate synthetase, wherein the nucleotide sequence is expressed in the patient; or (b) at least one enzymatically active fragment of a 2′-5′ oligoadenylate synthetase; wherein the RNA virus is a type that transiently produces double-stranded RNA during intermediate replication; and wherein the enzymatically active fragment of (a) and (b) comprises between 5 and 42 amino acids of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, or SEQ ID NO:12; or the enzymatically active fragment comprises at least 43 amino acids of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, or SEQ ID NO:12.