Patent ID: 7282496

Claim:
A compound of Formula (I): wherein: X is —S—, —SO—, —SO 2 — or —P(O)—R 8 ; Y is aryl or heteroaryl, with the proviso that X and Z may not be bonded to adjacent atoms of Y; Z is —O—, —NH—, —CH 2 — or —S—; R 1 is hydrogen, aryl, heteroaryl, C 5 -C 8 cycloheteroalkyl, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, or alkynyl of 2 to 6 carbon atoms; R 2 is hydrogen, aryl, heteroaryl, cycloalkyl of 3 to 6 carbon atoms, C 5 -C 8 cycloheteroalkyl, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, or alkynyl of 2 to 6 carbon atoms; or R 1 and R 2 , taken together with the atoms to which they are attached, may form a 3 to 7 membered cycloalkyl or cycloheteroalkyl ring; R 3 is hydrogen, cycloalkyl of 3 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms; or R 1 and R 3 , together with the atoms to which they are attached, may form a 5 to 8 membered ring wherein R 1 and R 3 represent divalent moieties of the formulae: A is aryl or heteroaryl; Q is a C—C single or double bond, —O—, —S—, —SO—, —SO 2 —, —NR 11 , or —CONR 12 ; s is an integer of 0 to 3; u is an integer of 1 to 4; m is an integer of 1 to 3; R 4 and R 5 are each, independently, hydrogen or alkyl of 1 to 6 carbon atoms; R 6 and R 7 are each, independently, hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, aryl, heteroaryl or C 5 -C 8 -cycloheteroalkyl; or R 6 and R 7 , together with the atom to which they are attached, may form 3 to 7 membered cycloalkyl or cycloheteroalkyl ring; R 8 is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, aryl or heteroaryl; R 9 and R 10 are each, independently, selected from H, —OR 13 , —NR 13 R 14 , alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, aryl, heteroaryl, —COOR 13 ; or —CONR 13 R 14 ; or R 9 and R 10 taken together form a C 3 -C 6 -cycloalkyl of 3 to 6 carbon atoms or a C 5 -C 8 -cycloheteroalkyl ring; or R 9 and R 10 taken together with the carbon to which they are attached, form a carbonyl group; R 11 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloheteroalkyl of 3 to 6 carbon atoms, aryl, heteroaryl, —S(O) n R 13 , —COOR 13 , —CONR 13 R 14 , —SO 2 NR 13 R 14 or —COR 13 , and n is an integer of 0 to 2; R 12 is hydrogen, aryl, heteroaryl, alkyl of 1-6 carbon atoms or cycloalkyl of 3-6 carbon atoms; and R 13 and R 14 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl or C 5 -C 8 -cycloheteroalkyl; or a pharmaceutically acceptable salt thereof.