Patent ID: 8299068

Claim:
A compound of a formula: wherein: Y is —Cl, —F, —Br, —CN, or —CF 3 ; X is C 0 -C 14 alkylene, alkenylene, or alkynylene; Z is optionally substituted methylene or C 2 -C 14 optionally substituted alkylene, optionally substituted alkenylene, or optionally substituted alkynylene; E is interarylene or interheteroarylene; R is H, C 1-6 alkyl, phenyl, —CH 2 CH 2 OH, or —CH 2 CH 2 —N(R 1 ) 2 wherein R 1 is C 1 to C 6 alkyl, or each R 1 taken together with the nitrogen atom forms a ring optionally containing an additional heteroatom; and A is unsubstituted cycloalkyl; or pharmaceutically acceptable salts, tautomers, enantiomers, and diastereomers thereof.