Patent ID: 8399450

Claim:
A compound having Formula (1): or pharmaceutically acceptable salts thereof; wherein W is A 1 and A 4 are independently C; each A 2 and A 3 is C; B and C are independently an optionally substituted 5-7 membered carbocyclic ring, aryl, heteroaryl or heterocyclic ring containing N, O or S; Z 1 , Z 2 and Z 3 are independently NR 11 , C═O, CR—OR, (CR 2 ) 1-2 or ═C—R 12 ; R 1 is halo or C 1-6 alkyl; R 2 is H; R 3 is SO 2 R 12 or cyano; R 4 , R 7 and R 10 are independently H; R, R 5 and R 5′ are independently H or C 1-6 alkyl; R 6 is —OR 12 ; one of R 8 and R 9 is (CR 2 ) q Y and the other is C 1-6 alkyl; R 11 is H, C 1-6 alkyl, C 2-6 alkenyl, (CR 2 ) p CO 1-2 R, (CR 2 ) p OR, (CR 2 ) p R 13 , (CR 2 ) p NRR 12 , (CR 2 ) p CONRR 12 or (CR 2 ) p SO 1-2 R 12 ; R 12 and R 13 are independently an optionally substituted 3-7 membered saturated or partially unsaturated carbocyclic ring, or a 5-7 membered heterocyclic ring comprising N, O and/or S; aryl or heteroaryl; or R 12 is H or C 1-6 alkyl; Y is an optionally substituted 3-12 membered carbocyclic ring, a 5-12 membered aryl, or a 5-12 membered heteroaryl comprising N, O and/or S and attached to A 2 or A 3 or both via a carbon atom of said heteroaryl n is 4; p is 0-4; and q is 0.