Patent ID: 7037915

Claim:
A compound which is a fused heteroaryl derivative of general formula (Ib): wherein: B is a thiophene ring; R 1 is a lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl which may have one or more substituents, heteroaryl which may have one or more substituents, halogen, —NO 2 , —CN, a halogenated lower alkyl, —ORb, —SRb, —SO 2 -Rb, —SO-Rb, —COORb, —CO-Rb, —CONRaRb, —SO 2 NRaRb, —NRaRb, —NRa-CORb, —NRa-SO 2 Rb, —O—CO—NRaRb, —NRaCO—COORb, —NRaCOORb, —NRaCO-lower alkylene-aryl, —NRa-SO 2 -lower alkylene-aryl, —NRa-lower alkylene-aryl, -lower alkylene-ORb, -lower alkylene-NRaRb, —CO-a nitrogen-containing saturated heterocyclic group, —CONRa-lower alkylene-ORb, —CONRa-lower alkylene-NRcRb, —CONRa-lower alkylene-nitrogen-containing saturated heterocyclic group, —O-lower alkylene-ORb, —O-lower alkylene-NRaRb, —O-lower alkylene-nitrogen-containing saturated heterocyclic group, —O-lower alkylene-O-lower alkylene-ORb, —O-lower alkylene-O-lower alkylene-NRaRb, —O-lower alkylene-NRc-lower alkylene-NRaRb, —NRc-lower alkylene-NRaRb, —N(a lower alkylene-NRaRb) 2 , —CONRa-ORb, —NRa-CO—NRbRc, or —OCORb; R 2 and R 3 are combined together with the N atom adjacent thereto to form a nitrogen-containing saturated heterocyclic group as —NR 2 R 3 which may have one or more substituents; each of Ra and Rc, which maybe the same or different, represents H or lower alkyl; Rb is H, lower alkyl, cycloalkyl, aryl which may have one or more substituents or a heteroaryl which may have one or more substituents; n is 2; W is N; R4 is -(aryl which may have one or more substituents), lower alkylene-(aryl which may have one or more substituents), lower alkenylene-(aryl which may have one or more substituents), lower alkynylene-(aryl which may have one or more substituents), -(cycloalkyl which may have one or more substituents), -(cycloalkenyl which may have one or more substituents), lower alkylene-(cycloalkyl which may have one or more substituents), lower alkenylene-(cycloalkyl which may have one or more substituents, lower alkylene-(nitrogen-containing saturated heterocyclic group which may have one or more substituents), lower alkenylene-(nitrogen-containing saturated heterocyclic group which may have one or more substituents), (a heteroaryl which may have one or more substituents and which is a 5 or 6 membered monocyclic heteroaryl containing 1 to 4 heteroatoms selected from N and S or a bicyclic heteroaryl which is a monocyclic heteroaryl as defined above is fused to a benzene ring), lower alkylene-(heteroaryl which may have one or more substituents), or lower alkenylene-(heteroaryl which may have one or more substituents); or a pharmaceutically acceptable salt thereof.