Patent ID: 8048659

Claim:
A water-soluble polymer linked to a solid support, comprising: a solid support optionally comprising a spacer sequence comprising one or more spacer monomer units attached to the solid support; and a water-soluble polymer covalently linked to the solid support or to the spacer sequence, the water-soluble polymer comprising a first cleavage segment of known composition and/or sequence comprising at least one monomer unit comprising a selectively cleavable link to the solid support or to the spacer sequence, wherein cleavage of the selectively cleavable link separates the water-soluble polymer from the solid support, a second segment of known composition and/or sequence comprising at least one monomer unit selected from the group consisting of a monomer unit linked to a reactive functionality able to be covalently coupled to a tag and a monomer unit linked to a tag, a third segment of known composition and/or sequence comprising one or more monomer units linked to a reactive functionality that can form a covalent bond with a member of a specific combining pair, and optionally one or more spacer monomer units provided adjacent to any segment and/or between any two segments and/or within any one or more of the second segment and the third segment.