Patent ID: 7138418

Claim:
A compound having the formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is —S(O)— or —SO 2 —; and Z is NR 1 R 2 ; wherein R 2 is an optionally substituted heteroaryl group having only one or two heteroatoms in the heteroaryl ring system thereof, and R 1 is selected from hydrogen, substituted or unsubstituted (C2–C10)alkyl, substituted or unsubstituted (C1–C10)alkoxy, substituted or unsubstituted (C3–C6)alkenyl, substituted or unsubstituted (C2–C6)heteroalkyl, substituted or unsubstituted (C3–C6)heteroalkenyl, substituted or unsubstituted (C3–C6)alkynyl, substituted or unsubstituted (C3–C8)cycloalkyl, substituted or unsubstituted (C5–C7)cycloalkenyl, substituted or unsubstituted (C5–C7)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryl-(C3–C8)cycloalkyl, substituted or unsubstituted aryl-(C5–C7)cycloalkenyl, substituted or unsubstituted aryloxy-(C3–C8)cycloalkyl, substituted or unsubstituted aryl-(C1–C4)alkyl, substituted or unsubstituted aryl-(C1–C4)alkoxy, substituted or unsubstituted aryl-(C3–C6)alkenyl, substituted or unsubstituted aryloxy-(C1–C4)alkyl, and substituted or unsubstituted aryloxy-(C2–C4)heteroalkyl, provided that in the case that Y is —S(O 2 )—, and R 1 is hydrogen or methyl, then R 2 is a substituted heteroaryl group: in the case that Y is —S(O 2 )—, and R 2 is a ring system chosen from 5-quinolyl, or 4-pyridyl, then either R 1 is not hydrogen or R 2 is substituted by at least one substituent that is not hydrogen; in the case that Y is —S(O 2 )— and R 2 is 2-methylbenzothiazol-5-yl, 6-hydroxy-4-methyl-pyrimidin-2-yl, 3-carbomethoxypyrazin-2-yl, 5-carbomethoxypyrazin-2-yl, 4-carboethoxy-1-phenylpyrazol-5-yl, 3-methylpyrazol-5-yl, 4-chloro-2-methylthiopyrimidin-6-yl, 2-trifluoromethyl-1-,3-,4-thiadiazol-5-yl, 4-methylthiazol-2-yl, 6,7-dihydroindan-5-yl, 7-chloro-5-methyl-1,8-naphthyridin-2-yl, 5,7-dimethyl-1,8-naphthyridin 2-yl, or 3-cyanopyrazol-4-yl, then R 1 is a group other than hydrogen; wherein said compound has pharmacological activity; and with the proviso that heteroaryl is other than 4-pyrimidyl.