Patent ID: 7399765

Claim:
A compound of the formula (I): Z-Ar 1 —Ar 2 (I) or a pharmaceutically acceptable salt, ester, or amide, thereof, wherein: Z is a diazabicyclic amine of the formula: Ar 1 is Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl is substituted with 0, 1, 2, or 3 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxysulfonyl, alkyl, alkylcarbonyl, arylcarbonyl, alkylcarbonyloxy, alkylsulfonyl, alkylthio, alkynyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, —NR A R B , (NR A R B )alkyl, (NR A R B )carbonyl, (NR A R B )sulfonyl, and phenyl; R 1 is selected from the group consisting of hydrogen, alkenyl, alkyl alkoxycarbonyl, arylalkyl, and heteroarylalkyl; R 2 at each occurrence is independently selected from the group consisting of hydrogen, alkoxycarbonyl, and alkyl; R 3 is selected from the group consisting of hydrogen, alkoxy, alkyl, cyano, and hydroxyl; R A and R B are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, arylcarbonyl, formyl and (NR C R D )sulfonyl; and R C and R D are each independently selected from the group consisting of hydrogen and alkyl.