Patent ID: 7227020

Claim:
A compound of formula (Ia): wherein: R 2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z 1 R 8 , —C(═O)—NY 3 Y 4 , —CO 2 R 8 , —NY 3 Y 4 , —N(R 6 )—C(═O)—R 7 , —N(R 6 )—C(═O)—NY 3 Y 4 , —N(R 6 )—C(═O)—OR 7 , —N(R 6 )—SO 2 —R 7 , —N(R 6 )—SO 2 —NY 3 Y 4 and one or more halogen atoms; R 3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, —C(═O)—OR 5; R 4 represents alkyl, cycloalkyl or cycloalkylalkyl each optionally substituted by a substituent selected from aryl, cycloalkyl, cyano, halo, heteroaryl, heterocycloalkyl, —CHO ( or a 5-, 6- or 7-membered cyclic acetal derivative thereof), —C(═O)—NY 1 Y 2 , —C(═O)—OR 5 , —NY 1 Y 2 , —N(R 6 )—C(═O)—R 7 , —N(R 6 )—C(═O)—NY 3 Y 4 , —N(R 6 )—SO 2 —R 7 , —N(R 6 )—SO 2 —NY 3 Y 4 , —OR 7 and one or more groups selected from hydroxy and carboxy; R 5 represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; R 6 represents hydrogen or lower alkyl; R 7 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R 8 represents hydrogen or lower alkyl; X 1 represents CH, C-halo, C-lower alkoxy, C-aryl, or C-CN Y 1 and Y 2 are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl or alkyl optionally substituted by one or more groups selected from aryl, halo, heteroaryl, hydroxy, —C(═O)—NY 3 Y 4 , —C(═O)—OR 5 , —NY 3 Y 4 , —N(R 6 )—C(═O)—R 7 , —N(R 6 )—C(═O)—NY 3 Y 4 , —N(R 6 )—SO 2 —R 7 , —N(R 6 )—SO 2 —NY 3 Y 4 and —OR 7 ; or the group —NY 1 Y 2 may form a cyclic amine; Y 3 and Y 4 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or the group —NY 3 Y 4 may form a cyclic amine; Z 1 represents O or S; Z 2 represents O or S(O) n ; n is zero or an integer 1 or 2; R 9 is hydrogen, R 4 , alkenyl or heterocycloalkyl; R 10 is alkenyloxy, carboxy, cyano, halo, hydroxy, heteroaryl, R 4 , —C(═)—R 4 , —C(═O)—NY 1 Y 2 , —OR 4 , —N(R 6 )—C(═O)—R 7 , —N(R 6 )—SO 2 —R 7 or —NY 1 Y 2 ; and p is zero, an integer 1 or 2; acceptable salt of said compound.