Patent ID: 8044035

Claim:
A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin, wherein the trioxopyrimidine derivative is a compound by formula (I): wherein R 1 is C 3 -C 20 alkyl, which may optionally be interrupted once or several times by —S—, —O— or —NH—; or a group W-V, wherein W is a chemical bond or phenyl; and V is phenyl, phenyloxy, phenylthio, phenylsulfinyl, phenylsulfonyl or phenylamino, which phenyl moieties may be unsubstituted or substituted once or several times by halogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 alkylsulfinyl, C 1 -C 6 -alkylamino, cyano, nitro or C 1 -C 6 -alkylsulfonyl; and R 2 is C 1 -C 10 alkyl, which alkyl group is unsubstituted or substituted one or two times by hydroxy or amino and may optionally be interrupted once or several times by —S—, —O— or —NH—; a benzoyl group, which may be unsubstituted or substituted once or several times by halogen, hydroxy, nitro, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl, amidosulfonyl, C 1 -C 6 -alkylamidosulfonyl, bis-C 1 -C 6 -alkylamidosulfonyl; a heteroaromatic acyl group; or a phenyl- or heteroaryl group, which are unsubstituted or substituted once or several times by halogen, hydroxyl, C 1 -C 6 -aloxy, C 1 -C 6 -alkylamino, C 1 -C 6 -dialkylamino, cyano, C 1 -C 6 -alkyl, C 2 -C 6 alkinyl, C 1 -C 6 -acyl, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkyl-aminocarbonyl, aminocarbonyl, C 1 -C 6 -alkylamidosulfonyl, amidosulfonyl, bis-C 1 -C 6 -alkylamidosulfonyl, nitro, C 1 -C 6 -alkoxycarbonyl, carboxy; and wherein the trioxopyrimidine derivative is 5-Biphenyl-4-yl-5[4-(4-nitro-phenyl)-piperazin-1-yl]pyrimidine-2,4,6-trione; 5-(4-Phenoxy-phenyl)-5-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrimidine-2,4,6-trione; 5[4-(4-Chloro-phenoxy)-phenyl]-5-(4-pyrimidin-2-yl-piperazin- -1-yl)- pyrimidine-2,4,6-trione; 5-[4-(3,4-Dichloro-phenoxy)-phenyl]-5-(4-pyrimidin-2-yl-piperazin-1-yl)- pyrimidine-2,4,6-trione; 5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-pyrimidin-2-yl-piperazin-1-yl)- pyrimidine-2,4,6-trione or a salt thereof.