Patent ID: 7501430

Claim:
A compound of formula II, or pharmaceutically acceptable salts thereof: wherein X is O, S(O) p ; m is an integer from 1 to 3; n is an integer from 1 to 3; p is an integer from 0 to 2; Z is hydrogen, a bond, —C(O)—, —C(O)NR 11 —, —S(O) 2 —, —C(O)NH—S(O) 2 —, or CH(OH)—CH 2 —Y—, wherein Y is CH 2 , O, S, NH, or a bond; R 1 is —(CH 2 ) 0-3 —C(O)NR 6 R 7 , —NR 8 SO 2 R 9 , —NR 8 C(O)NR 6 R 7 , —NR 8 C(S)NR 6 R 7 , —OSO 2 NR 6 R 7 , —C(N—OH)NH 2 , —C(N—OH)R 8 , —CH 2 OR 8 , —OC(O)NR 6 R 7 , —SR 9 , or —C(O)NR 8 SO 2 R 9 ; R 2 is hydrogen, —(CH 2 ) 0-3 —C(O)NR 6 R 7 , —NR 8 SO 2 R 9 , —NR 8 C(O)NR 6 R 7 , —NR 8 C(S)NR 6 R 7 , —OSO 2 NR 6 R 7 , —C(N—OH)NH 2 , —C(N—OH)R 8 , —CH 2 OR 8 , —OC(O)NR 6 R 7 , —SR 9 , or —C(O)NR 8 SO 2 R 9 , or R 1 and R 2 , taken together, may form a ring; R 3 and R 4 are independently hydrogen, substituted or unsubstituted lower alkyl, —COOH, —COOR 8 , or —C(O)NR 10 R 11 ; each R 6 and each R 7 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl, or R 6 and R 7 , taken together, may form a ring; each R 8 is independently hydrogen, or substituted or unsubstituted lower alkyl; each R 9 is independently substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heteroaryl; R 10 is substituted or unsubstituted lower alkyl, or substituted or unsubstituted aryl; R 11 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heteroaryl, or R 11 , taken together with R 10 , may form a ring; R 12 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heteroaryl; and R 13 is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, C 1 -C 8 fluoro-substituted alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 fluoro-substituted cycloalkyl, aryl, halogen-substituted aryl, heteroaryl, and halogen-substituted heteroaryl.