Patent ID: 8450280

Claim:
A composition comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide comprising an amino acid sequence having a cleavage site specific for an enzyme having a proteolytic activity of human kallikrein 2 (hK2), wherein the peptide is linked to the therapeutically active drug to inhibit the therapeutic activity of the drug, and wherein the therapeutically active drug is cleaved from the peptide upon proteolysis by an enzyme having a proteolytic activity of hK2, and wherein the peptide comprises an amino acid sequence selected from the group consisting of: SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 70, SEQ ID NO: 71, SEQ ID NO: 72, SEQ ID NO: 73, SEQ ID NO: 74, SEQ ID NO: 93, SEQ ID NO: 102, and SEQ ID NO: 104.