Patent ID: 8877225

Claim:
A controlled release formulation comprising a constant release copolymer composition, a bioactive agent, and an organic solvent having at least a slight solubility in body fluid wherein the constant release copolymer composition comprises a mixture of a PLG copolymer and a PLG oligomer, the PLG copolymer is a poly(lactide-glycolide) copolymer without a core diol unit, the poly(lactide-glycolide) copolymer having a monomer molar proportion of up to 100 mole % lactide to 100 mole % glycolide, the PLG oligomer is a poly(lactide-glycolide) oligomer with a core diol unit, the PLG oligomer having a monomer molar proportion of up to 100 mole % lactide, the PLG oligomer having a weight average molecular weight of about 5 to 10 kDa, and the PLG oligomer being present in about 2 wt % to about 10 wt % of the total weight of the PLG copolymer and PLG oligomer.