Patent ID: 8227507

Claim:
A method for treating a dermatological condition selected from the group consisting of acne vulgaris, comedonic acne, polymorphic acne, nodulocystic acne, acne conglobata and secondary acne, said method comprising administering to an individual in need of such treatment, an effective amount of a pharmaceutical composition comprising a pharmaceutically effective amount of at least one ligand compound having the formula (I) below: in which: R 1 is a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a —CF 3 radical; R 2 is a hydrogen atom, an alkyl or alkoxy radical of 1 to 4 carbon atoms or a chlorine atom; R 3 is a hydrogen atom or a linear or branched alkyl or alkoxy radical of 1 to 10 carbon atoms optionally substituted with a methoxy group; R 4 is a hydrogen atom or an alkyl radical of 1 to 3 carbon atoms; R 5 is a hydrogen atom or an alkyl radical of 1 to 3 carbon atoms; or alternatively R 4 and R 5 form, together with the bond —N—C(═Y)—, a pyrrolidine, pyrrolidinone, piperidine or piperidinone ring; Y is two hydrogen atoms or a hetero atom; Ar is a 1,4-phenyl, 2,5-pyridyl, 5,2-pyridyl or 2,5-thiophenyl ring; X is an oxygen atom optionally substituted with an alkyl or alkylamine radical or a C—C single bond; and A is a hydrogen atom or the following formula: in which: Q is an oxygen atom or an —NH— bond; R 6 is a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms, a cycloalkyl radical of 3 to 6 carbon atoms or a —C(O)CH 3 or —C(O)CH 2 CH 3 radical; R 7 and R 7 ′ represent, independently of each other, a hydrogen atom or a hydroxyl group, with the provisio that R 7 and R 7 ′ are not simultaneously a hydroxyl group; and n is 0, 1, 2, 3, 4 or 5; or a salt of a compound of formula (I) when R 3 is a hydrogen atom, or a geometrical isomer of a compound of formula (I); formulated into a pharmaceutically and physiologically acceptable medium therefor.