Patent ID: 8409563

Claim:
A method for producing a purine-derived substance, which comprises (A) culturing a bacterium belonging to the genus Bacillus which is able to produce a purine-derived substance in a medium, and (B) collecting the purine-derived substance from the bacterium or medium, wherein the bacterium has been modified to decrease the enzymatic activity of fructose bisphosphatase, wherein said fructose bisphosphatase is selected from the group consisting of: (i) a protein comprising the amino acid sequence of SEQ ID NO: 2, (ii) a protein comprising the amino acid sequence of SEQ ID NO: 2, but which includes substitutions, deletions, insertions, or additions, of one to 10 amino acid residues and has fructose bisphosphatase activity, and (iii) combinations thereof; wherein the fructose bisphosphatase activity is decreased by disrupting a gene encoding fructose bisphosphatase, or decreasing the expression of a gene encoding fructose bisphosphatase.