Patent ID: 8802147

Claim:
A biodegradable polyamide ester of formula VIII or IX, or a pharmaceutically acceptable salt thereof: (C) —[(X 1 ) c O(O═)C—R 9 —C(═O)O—(Y 1 ) d —(Y 2 ) a —CH 2 (O═)C—NH—R 10 —NH—C(═O)CH 2 —(X 2 ) b ] o — VIII wherein the polyamide ester of formula VIII is formed by condensation polymerization of monomers of formula Va and VII: H—(X 1 ) c —O(O═)C—R 9 —C(═O)O—(Y 1 ) d —H Va R 11 —(Y 2 ) a —CH 2 (O═)C—NH—R 10 —NH—C(═O)CH 2 —(X 2 ) b —R 12 VII (D) —[(X) a —O—R 1 —O—(Y) b —(Y 2 ) a —CH 2 (O═)C—NH—R 10 —NH—C(═O)CH 2 —(X 2 ) b ] p — IX wherein the polyamide ester of formula IX is formed by condensation polymerization of monomers of formula I and VII: H—(X) a —O—R 1 —O—(Y) b —H I R 11 —(Y 2 ) a —CH 2 (O═)C—NH—R 10 —NH—C(═O)CH 2 —(X 2 ) b —R 12 VII wherein: o and p are each independently an integer from about 5 to about 1000; R 1 and R 9 are each independently the remaining portion of a biologically active compound; R 10 is the remaining portion of a biologically active compound or non-biologically active compound; R 11 and R 12 are each independently selected from Cl, F, Br, and I; X, X 1 and X 2 are independently at each occurrence —OC(═O)CH 2 — (inverse glycolic acid moiety), —OC(═O)CH(CH 3 )— (inverse lactic acid moiety), —OC(═O)CH 2 OCH 2 CH 2 — (inverse dioxanone acid moiety), —OC(═O)CH 2 CH 2 CH 2 CH 2 CH 2 — (inverse caprolactone acid moiety), —OC(═O)(CH 2 ) y —, or —OC(═O)CH 2 (OCH 2 CH 2 ) z —; Y, Y 1 , and Y 2 are independently at each occurrence —CH 2 C(═O)O— (glycolic acid moiety), —CH(CH 3 )C(═O)O— (lactic acid moiety), —CH 2 CH 2 OCH 2 C(═O)O— (dioxanone moiety), —CH 2 CH 2 CH 2 CH 2 CH 2 C(═O)O— (caprolactone moiety), —(CH 2 ) y C(═O)O—, or —(CH 2 CH 2 O) z CH 2 C(═O)O—; each y and z is independently an integer from about 2 to about 24; each a, b, c, and d is independently an integer from about 1 to about 6.