Patent ID: 8309134

Claim:
A method for preparing non-aggregating calcium phosphate nanoparticles comprising: (a) adding an active ingredient to one of a calcium salt solution or a phosphoric acid salt solution; (b) forming a mixed solution by mixing said calcium salt solution with said phosphoric acid salt solution; (c) adjusting the pH of said mixed solution to a level greater than 7.0 and less than or equal to 10.0, thereby forming calcium phosphate nanoparticles; (d) terminating the formation of said calcium phosphate nanoparticles by adding a polycation and/or polyanion to said mixed solution, wherein said polycation or polyanion has a number average molecular weight (Mn) of 100-30,000 and is added from a solution containing said polycation or polyanion, said solution containing said polycation or polyanion being added at a level of 0.05%-10.0% by volume of said mixed solution.