Patent ID: 6884801

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R 2 , R 3 , R 4 , and R 5 are independently H, halogen, —OH, —C 1-3 alkyl, —C 1-3 alkoxy, —SC 1-2 alkyl, or —CF 3 , with the proviso that at least 2 of R 2 , R 3 , R 4 , and R 5 are H; R 6 is H or —CH 3 ; R 1 is —S(O) n R 7 where n is 1 or 2, —S(O) 2 NHR 8 , —C(O)R 9 , —NR 14 R 15 , —C(R 17 )═NOR 16 , or a 5, 6, or 7 membered heteroalkyl or heteroaryl group optionally substituted with 1 or two groups selected from the group consisting of the following substituents for carbon: C 1-3 alkyl, —CH 2 CF 3 , —CF 3 , F, Cl, C 1-2 alkoxy, C 1-2 thioalkyl, and the following substituents for nitrogen: C 1-3 alkyl and —CH 2 C 1-2 fluoroalkyl; R 7 is C 1-3 alkyl or C 1-2 fluoroalkyl; R 8 is C 1-3 alkyl or —CH 2 C 1-2 fluoroalkyl; R 9 is C 1-3 alkyl optionally substituted with 1-3 fluorine atoms, —NR 10 R 11 , —NHNR 12 R 13 , —CH 2 SO 2 CH 3 , R 10 is H or C 1-2 alkyl; R 11 is H, cyclopropyl, cyclopropylmethyl, C 3-6 alkenyl with the proviso that any unsaturation is not adjacent to the depicted nitrogen, or C 1-6 alkyl optionally substituted with hydroxy, C 1-3 alkoxy, or 1-3 fluorine atoms with the proviso that the carbon atom in R 11 that is bonded to the depicted nitrogen is not bonded to either a fluorine or an oxygen; R 12 is H or C 1-2 alkyl; R 13 is H, C 3-5 cycloalkyl, cyclopropylmethyl, —SO 2 CH 3 , —C(O)CH 3 , C 3-6 alkenyl with the proviso that any unsaturation is not adjacent to the depicted nitrogen, or C 1-6 alkyl optionally substituted with hydroxy, C 1-3 alkoxy, or 1-3 fluorine atoms with the proviso that the carbon atom in R 13 that is bonded to the depicted nitrogen is not bonded to either a fluorine or an oxygen; R 14 is H or C 1-2 alkyl; R 15 is C 3-5 cycloalkyl, cyclopropylmethyl, C 3-6 alkenyl with the proviso that any unsaturation is not adjacent to the depicted nitrogen, or C 1-6 alkyl optionally substituted with hydroxy, C 1-3 alkoxy, or 1-3 fluorine atoms with the proviso that the carbon atom in R 15 that is bonded to the depicted nitrogen is not bonded to either a fluorine or an oxygen; R 16 is C 1-2 alkyl; R 17 is H or C 1-3 alkyl; R 20 is H; and R 18 , R 19 , R 21 , and R 22 are independently H, halogen, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —SC 1-2 alkyl, or —CF 3 with the proviso that at least one of R 18 , R 19 , R 21 , or R 22 is other than H.