Patent ID: 8722901

Claim:
A compound of formula (I) wherein, Z is selected from unsubstituted or substituted alkylcycloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl and unsubstituted or substituted heterocycle, wherein each of substituted alkylcycloalkyl, cycloalkyl, aryl, heteroaryl and heterocycle is substituted with one or more substituents selected from R a ; R a at each occurrence is selected from halogen, oxo, thio, nitro, —CN, —OR x , —S(═O) m R x , —S(═O) n NR 1 R 2 , —OCOR x , —SCOR x , —NR x R y , —NR x COR y , —NR x COOR y , —NR x SOR y , —NR x SO 2 R y , —NR x CONR x R y , —COR x , —COOR x , —CONR x R y , —(CR x R y ) n —OR x , alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, aryl, alkylaryl, heterocyclyl, alkylheterocyclyl, heteroaryl and alkylheteroaryl; wherein R x and R y are independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, aryl, alkylaryl, heterocyclyl, alkylheterocyclyl, heteroaryl and alkylheteroaryl; said alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, aryl, alkylaryl, heterocyclyl, alkylheterocyclyl, heteroaryl and alkylheteroaryl are optionally substituted with R b ; R b at each occurrence is selected from halogen, nitro, —CN, hydroxy, alkoxy, —COOH, —NH 2 and alkyl; Y is selected from —(CH 2 )—N(R 4 )—, —N(R 4 )—, —N(R 4 )CON(R 5 )—, —N(R 4 )CSN(R 5 )—, —NR 4 C(O)—, —N(R 4 )(C═NR 4 )N(R 5 )—, —CON(R 4 )—, —NR 4 SO 2 — and —SO 2 NR 4 —; U is selected from wherein T is —O— or —S—; V is selected from —CONR 4 —, —CSNR 4 —, —C(O), —C(S)—, —COC(R 4 )(R 5 ) and —SO 2 NR 4 ; R 3 is selected from —COOR p , —CONR p R q , —CONR p SO 2 R q and a carboxylic acid isostere selected from tetrazol-5-yl, 5-trifluoromethyl-1,2,4-triazol-3-yl, 5-(methylsulfonyl)-1,2,4-triazol-3-yl and 2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl; R 1 , R 2 , R 4 and R 5 at each occurence are independently selected from H and unsubstituted or substituted alkyl, wherein substituted alkyl is substituted with substituents selected from R a ; R p and R q are independently selected from H, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocyclyl, or unsubstituted or substituted heteroaryl, wherein each of substituted alkyl, aryl, heterocycle and heteroaryl is substituted with one or more substituents selected from R a ; or R 1 and R 2 together with the carbon to which they are attached form a three- to six-membered carbocylic ring, wherein the ring may be optionally substituted with one or more substituents selected from R a ; m is an integer from 0 to 2; n is an integer from 1 to 2; * indicates the point of attachment to —V— and indicates the point of attachment to phenyl ring; or a stereoisomer, tautomer or a pharmaceutically acceptable salt thereof.