Patent ID: 8637486

Claim:
A method of reducing DNA methylation comprising administering to a subject in need thereof, a compound of Formula (I): wherein R 1 is H, a sugar or substituted sugar moiety, a sugar analogue, or a group which is replaced in vivo by the sugar or substituted sugar moiety or the sugar analogue; wherein R 2 is 2 H or ZX 3 where Z may be 12 C or 13 C and X may be 2 H or 1 H; wherein R 3 is 1 H or 2 H; where Q 1 and Q 2 can be 12 C or 13 C; and with the provision that at least one atom in R 2 , R 3 , Q 1 or Q 2 is a heavy isotope; wherein the 13 C, 2 H or both are enriched at least 20% more individually or collectively in comparison to naturally occurring 13 C, 2 H or both at the same position in the compound, or a pharmaceutically acceptable salt of a compound of Formula (I); wherein the compound of Formula (I) is incorporated into the subject's DNA as an isotopically modified compound following administration; wherein the compound of Formula (I) is administered to the subject in need thereof in an amount that reduces DNA methylation such that harmful disease effects are mitigated.