Patent ID: 8906935

Claim:
A method for inhibiting poly(ADP-ribose) polymerase thereby treating and/or reducing tissue damage due to ischemia with a compound of formula I: wherein: X is C 1 -C 9 alkylene, C 2 -C 9 alkenylene, or C 2 -C 9 alkynylene; Y is O or S; R 1 is hydrogen, hydroxy, or OR 7 ; R 2 , R 3 , and R 4 are hydrogen; R 5 and R 6 are C 1 -C 6 alkyl, optionally substituted with one or more groups selected from hydroxy, C 1 -C 4 alkoxy, —CO 2 H, C 1 -C 6 alkoxycarbonyl, NH 2 , C 1 -C 6 mono- or dialkylamino, and halogen; or R 5 and R 6 together with the nitrogen to which they are attached form a saturated, partially unsaturated, or unsaturated 3 to 12 membered monocyclic or bicyclic heterocyclic ring optionally comprising from one to three additional ring heteroatoms independently selected from N, O, and S, and the remainder of the ring atoms are carbon atoms; R 7 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 3 -C 7 cycloalkyl, wherein the alkyl, alkenyl, and cycloalkyl are optionally substituted with one or more groups independently selected from hydroxy, C 1 -C 4 alkoxy, —CO 2 H, C 1 -C 6 alkoxycarbonyl, NH 2 , C 1 -C 6 mono- or dialkylamino, and halogen; or a pharmaceutically acceptable salt form thereof.