Patent ID: 7268159

Claim:
A compound having the formula: or a pharmaceutically acceptable salt or ester form thereof, wherein: X is a bond or C 1 -C 6 alkylene; R 1 and R 2 are, independently, hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 8 cycloalkyl, C 7 -C 11 bicycloalkyl, C 6 -C 10 aryl, heterocycle, —C(═O)C 1 -C 6 alkyl, —C(═O)aryl, —C(═O)heterocycle, —C(═O)N(R 6 )C 1 -C 6 alkyl, —C(═O)N(R 6 )aryl, —C(═O)N(R 6 )heterocycle, —SO 2 —C 1 -C 6 alkyl, —SO 2 -aryl, or —SO 2 -heterocycle; or R 1 and R 2 together with the nitrogen to which they are attached form a heterocycle; R 3 and R 4 are independently, hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 6 alkoxy, C 3 -C 8 cycloalkyl, —C(═O)C 1 -C 3 alkyl, —OH, —NH 2 , or —NO 2 ; R 5 is hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 8 cycloalkyl, C 7 -C 11 bicycloalkyl, C 6 -C 10 aryl, or heterocycle; A is hydrogen, C 6 -C 10 aryl, or heterocycle; and R 6 is hydrogen, C 1 -C 6 alkyl, halogen, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 8 cycloalkyl, aralkyl, C 6 -C 10 aryl, heterocycle, hydroxy, C 1 -C 6 alkoxy, aryl-oxy, —CN, —(═O)H, —CO 2 H, —OCO 2 C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —CO 2 -aryl, —CO 2 (C 1 -C 6 alkyl)aryl, —OCO 2 -aryl, —C(═O)NH 2 , —C(═O)NHOH, amino, C 1 -C 6 alkylamino, dialkylamino of 1-6 carbons per alkyl moiety, —NHC(═O)NH—C 1 -C 6 alkyl, —NHSO 2 —C 1 -C 6 alkyl, —NHSO 2 -aryl, or —NHSO 2 -heterocycle; and wherein each of said alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl and heterocycle groups being optionally substituted by one, two, three or more substituents.