Patent ID: 8128967

Claim:
A pharmaceutical composition comprising at least one green tea polyphenol in combination with a non-polyphenol cyclooxygenase-2 (COX-2) inhibitor, wherein the composition comprises an effective amount of the polyphenol and the COX-2 inhibitor to reduce tumor incidence in a mammal, wherein the polyphenol is selected from the group consisting of epigallocatechin gallate and polyphenon E, wherein the non-polyphenol COX-2 inhibitor is selected from the group consisting of rofecoxib, celecoxib, and valdecoxib, and wherein the combination of the polyphenol and the COX-2 inhibitor are present in amounts of between 50 and 1500 mg and between 1 to 1000 mg, respectively, that are effective to achieve a synergistic effect to reduce tumor incidence and multiplicity in an amount of at least 10% as compared to tumor incidence and multiplicity without treatment.