Patent ID: 7125893

Claim:
An epothilone compound of formula I, in which R 1a , R 1b are the same or different and mean hydrogen; C 1 –C 10 alkyl, C 6 –C 12 aryl, or C 7 –C 20 aralkyl, each, except hydrogen, is optionally substituted; R 2a means hydrogen, C 1 –C 10 alkyl, C 6 –C 12 aryl or C 7 –C 20 aralkyl, each, except hydrogen, is optionally substituted; —(CH 2 ) ra —C≡C—(CH 2 ) pa —R 26a ; or —(CH 2 ) ra —CH═CH—(CH 2 ) pa —R 26a , R 2b means —(CH 2 ) rb —C≡C—(CH 2 ) pb —R 26b , or —(CH 2 ) rb —CH═CH—(CH 2 ) pb —R 26b , ra, rb are the same or different and mean 0 to 4, pa, pb are the same or different and mean 0 to 3, R 3a means hydrogen or a C 1 –C 10 alkyl, C 6 –C 12 aryl or C 7 –C 20 aralkyl, each, except hydrogen, is optionally substituted, R 3b means OH or OPG 14 where PG 14 is a protective group, R 14 means hydrogen, OR 14a or Hal, where R 14a is hydrogen, SO 2 -alkyl, SO 2 -aryl or SO 2 -aralkyl, R 4 means hydrogen, C 1 –C 10 alkyl, C 6 –C 12 aryl or C 7 –C 20 aralkyl, each, except hydrogen, is optionally substituted Hal; OR 25 ; or CN; R 25 means hydrogen or a protective group PG 5 , R 26 , R 26b are the same or different and mean hydrogen; C 1 –C 10 alkyl, C 6 –C 12 aryl or C 7 –C 20 aralkyl, each, except hydrogen, is optionally substituted C 1 –C 10 acyl, or, if pa or pb>0, additionally a group OR 27 , R 27 means hydrogen or a protective group PG 6 , R 5 means hydrogen, C 1 –C 10 alkyl, C 6 –C 12 aryl, C 7 –C 20 aralkyl, each optionally substituted; or (CH 2 ) s -T, whereby s stands for 1, 2, 3 or 4, T stands for OR 22 or Hal, R 22 stands for hydrogen or a protective group PG 4 , R 6 , R 7 each mean a hydrogen atom, or taken together an additional bond or an oxygen atom, G means a benzothiazolyl, benzoxazolyl or quinolinyl radical which is optionally substituted by halogen, OH, O-alkyl, CO 2 H, CO 2 -alkyl, —NH 2 , —NO 2 , —N 3 , —CN, C 1 –C 20 alkyl, C 1 –C 20 acyl, or C 1 –C 20 acyloxy groups, D-E means a group —CH 2 —CH 2 —, A-Y means a group O—C(═O), or NR 29 —C(═O), R 29 means hydrogen or C 1 –C 10 alkyl, Z means an oxygen atom, Hal means halogen, wherein, in each occurrence “PG” together means a hydroxy protecting group.