Patent ID: 8143426

Claim:
A compound of Formula I: wherein Z 1 and Z 2 are each independently CH or N; R 1 is H or optionally substituted hydroxy, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 2 and R 2 ′ are each independently H or optionally substituted alkyl, cycloalkyl, or heterocycloalkyl, or when R 2 ′ is H then R 2 and R 1 can together form an aziridine or azetidine ring; R 3 and R 4 are each independently H or optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; or, R 3 and R 4 are each carbon and are linked by a covalent bond or by an optionally-substituted alkylene or alkenylene group of 1 to 8 carbon atoms where one to three carbon atoms can be replaced by N, O, S(O) n , or C═O; R 5 and R 6 are each independently H or optionally substituted hydroxy, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; or R 5 and R 6 are each carbon and are linked by a covalent bond or by an optionally-substituted alkylene or alkenylene group of 1 to 8 carbon atoms where one to three carbon atoms can be replaced by N, O, S(O) n , or C═O; M is a bond, optionally substituted alkylene group of 1 to 5 carbon atoms, optionally substituted with a lower alkyl; or M and G together form a bond; G is a bond, a heteroatom, —S(O) n —, —NR 8 —, —NCOR 8 —, or —NS(O) n R 8 —, where R 8 is selected from the group consisting of lower alkyl, optionally-substituted lower alkyl and C 3-8 cycloalkyl; or M and G together form a bond; R 7 is a cycloalkyl, a heterocycloalkyl, an aryl, or a heteroaryl, each substituted with -L1-R 10 and each cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally further substituted; L1 is a covalent bond or C 1-6 alkylene, alkenylene, or alkynylene; R 10 is an optionally substituted 5-, 6-, or 7-membered heterocycloalkyl with at least one N or O atom in the ring or R 10 is heteroaryl with at least one N atom in the ring; each n can be the same or different and is 0, 1, or 2; or a pharmaceutically acceptable salt thereof.