Patent ID: 7741493

Claim:
A compound of formula II or a pharmaceutically acceptable salt thereof: wherein: R is hydrogen, or C 1-6 alkyl; R 1 and R 3 taken together with the carbon atoms to which they are attached form a cyclopentane, cyclohexane, cycloheptane or cyclooctane; R 2 and R 4 are the same or different and are each independently selected from: hydrogen, C 1-6 alkyl or fluoroalkyl of the formula C n H x F y , wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1; R 5 is phenyl, which is optionally substituted with one or more substituents selected from the group consisting of halogen, C 1-4 alkyl, fluoroalkyl of the formula C n H x F y and fluoroalkoxy OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, C 1-4 alkoxy, C 1-4 thioalkyl, hydroxy, C 1-4 acyloxy, nitro, amino, C 1-4 alkylamino, C 1-4 dialkylamino, amino C 1-4 alkyl, C 1-4 alkylamino C 1-4 alkyl, C 1-4 dialkylamino C 1-4 alkyl, —CN, —CO 2 H, —CO 2 C 1-4 alkyl, phenyl, phenoxy and benzyloxy; X—Y is —(CH 2 ) a —Z—(CH 2 ) b —, wherein (CH 2 ) is optionally substituted with one or more groups selected independently from: hydroxy, C 1-6 alkoxy, arylaminocarbonyloxy, C 3-8 cycloalkyl, and fluoroalkyl of the formula C n H x F y , wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, wherein said alkoxy or fluoroalkyl is optionally substituted with a substituent selected from the group consisting of: hydroxy, —SH, C 1-4 alkoxy, C 1-4 thioalkyl, C 1-4 acyloxy, nitro, amino, C 1-4 alkylamino, C 1-4 dialkylamino, —CN, —CO 2 H, —CO 2 C 1-4 alkyl and aryl; Z is NR 6 , wherein R 6 is selected from: hydrogen, C 1-6 alkoxy, C 1-6 alkyl or fluoroalkyl of the formula C n H x F y , wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, wherein said alkoxy or alkyl or fluoroalkyl is optionally substituted with at least one substituent selected from the group consisting of: hydroxy, —SH, C 1-4 alkoxy, C 1-4 thioalkyl, C 1-4 acyloxy, nitro, amino, C 1-4 alkylamino, C 1-4 dialkylamino, —CN, —CO 2 H, —CO 2 C 1-4 alkyl and aryl; and a is 0 and b is an integer from 1 to 4.