Patent ID: 7935687

Claim:
A method for treating a subject for spinal muscular atrophy, comprising: administering to said subject an effective amount of a tetracycline compound of formula I: wherein X is CR 6′ R 6 ; R 2 and R 2′ are each hydrogen; R 4 ′ and R 4 ″ are each alkyl; R 3 , R 4a , R 11 and R 12 are each hydrogen; R 4 is NR 4′ R 4″ ; R 5 and R 5 ′ are each hydrogen; R 6 and R 6 ′ are each hydrogen; R 7 is acyl, amino, phenyl, pyridinyl, furanyl, pyrrolyl, tetrahydropyridinyl, quinolinyl, or aminoalkyl; R 8 is hydrogen; R 9 is hydrogen or phenyl; and R 10 is hydroxyl; or a pharmaceutically acceptable salt, ester or enantiomer thereof, such that said spinal muscular atrophy in said subject is treated.