Patent ID: 8207147

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof: R 1 -V-B—R 2 (I) wherein V represents a 5-membered heteroaryl ring of the formula: wherein W is N and one of X and Y is N and the other is O; B is —CH═CH— or (CH 2 ) n , where one of the CH 2 groups may be replaced by O, NR 5 , S(O) m , C(O) or C(O)NR 12 ; n is 2 or 3; m is 0, 1 or 2; R 1 is 4-pyridyl optionally substituted by 1 or 2 halo, C 1-4 alkyl, C 1-4 fluoroalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-7 cycloalkyl, aryl, OR 6 , CN, NO 2 , S(O) m R 6 , CON(R 6 ) 2 , N(R 6 ) 2 , NR 10 COR 6 , NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl groups; R 2 is 4- to 7-membered cycloalkyl substituted by R 3 , C(O)OR 3 , C(O)R 3 or S(O) 2 R 3 , or R 2 is 4- to 7-membered heterocyclyl, wherein the heterocycle contains one nitrogen atom which is substituted by C(O)OR 4 , C(O)R 3 , S(O) 2 R 3 , C(O)NHR 4 , P(O)(OR 11 ) 2 or a 5- or 6-membered nitrogen containing heteroaryl group; R 3 is C 3-8 alkyl, C 3-8 alkenyl or C 3-8 alkynyl, any of which may be optionally substituted with up to 5 fluoro or chloro atoms, and may contain a CH 2 group that may be replaced by O, or C 3-7 cycloalkyl, aryl, heterocyclyl, heteroaryl, C 1-4 alkylC 3-7 cycloalkyl, C 1-4 alkylaryl, C 1-4 alkylheterocyclyl or C 1-4 alkylheteroaryl, any of which may be optionally substituted with one or more substituents selected from halo, C 1-4 alkyl, C 1-4 fluoroalkyl, OR 6 , CN, CO 2 C 1-4 alkyl, N(R 6 ) 2 and NO 2 ; R 4 is C 2-8 alkyl, C 2-8 alkenyl or C 2-8 alkynyl, any of which may be optionally substituted with up to 5 fluoro or chloro atoms, and may contain a CH 2 group that may be replaced by O, or C 3-7 cycloalkyl, aryl, heterocyclyl, heteroaryl, C 1-4 alkylC 3-7 cycloalkyl, C 1-4 alkylaryl, C 1-4 alkylheterocyclyl or C 1-4 alkylheteroaryl, any of which may be substituted with one or more substituents selected from halo, C 1-4 alkyl, C 1-4 fluoroalkyl, OR 6 , CN, CO 2 C 1-4 alkyl, N(R 6 ) 2 and NO 2 ; R 5 is hydrogen, C(O)R 7 , S(O) 2 R 8 , C 3-7 cycloalkyl or C 1-4 alkyl optionally substituted by OR 6 , C 3-7 cycloalkyl aryl, heterocyclyl or heteroaryl, wherein the cyclic groups may be substituted with one or more substituents selected from halo, C 1-2 alkyl C 1-2 fluoroalkyl, OR 6 , CN, N(R 6 ) 2 and NO 2 ; R 6 are independently hydrogen C 1-4 alkyl, C 3-7 cycloalkyl, aryl, heterocyclyl or heteroaryl, wherein the cyclic groups may be substituted with one or more substituents selected from halo, C 1-4 alkyl C 1-4 fluoroalkyl, OR 9 , CN, SO 2 CH 3 , N(R 10 ) 2 and NO 2 ; or a group N(R 10 ) 2 may form a 4- to 7-membered heterocyclic ring optionally containing a further heteroatom selected from O and NR 10 ; R 7 is hydrogen, C 1-4 alkyl, OR 6 , N(R 6 ) 2 , aryl or heteroaryl; R 8 is C 1-4 alkyl, C 1-4 fluoroalkyl, aryl or heteroaryl; R 9 is hydrogen, C 1-2 alkyl or C 1-2 fluoroalkyl; R 10 is hydrogen or C 1-4 alkyl; R 11 is phenyl; and R 12 is hydrogen, C 1-4 alkyl or C 3-7 cycloalkyl.