Patent ID: 7956049

Claim:
A compound of Formula I wherein A is selected from the group consisting of mono-cyclic aryl, mono-cyclic heteroaryl and bi-cyclic heteroaryl; D is selected from the group consisting of a direct bond, alkyl, cycloalkyl and heterocyclyl; Q is selected from the group consisting of —(CR 8 R 9 ) n —, —C(R 8 R 9 )C(O)—, —C(O)C(R 8 R 9 )—, —(CO) m —, —C(O)CR 8 R 9 C(O)—, and —CR 8 ═CR 9 —; W is selected from the group consisting of a direct bond, —C(O)—, —O—, —N(R 9a )—, —S(O)—, —S(O 2 )—, —S(O 2 )N(R 9a )— and —C(R 10 )(R 11 )—; R 1a , R 1b and R 1c are independently selected from the group consisting of hydrogen, halo, aryl, aryloxy, arylthio, arylalkylthio, and heteroaryl, wherein aryl and heteroaryl, alone or as part of another group, may optionally and independently, be substituted with 1-3 R 4 ; R 2 is selected from the group consisting of hydrogen, hydroxyl, lower alkoxy, hydroxyalkyl, lower cycloalkoxy, OCONR 7 R 7a CN, CONR 7 R 7a , SOR 6 , SO 2 R 6 , NR 7 COR 7b NR 7 CO 2 R 7b , CO 2 R 6 , heterocyclyl, heteroaryl, NR 7 R 7a , NR 7 SO 2 R 6 and COR 6 ; R 3 is selected from the group consisting of hydrogen, hydroxyl, alkoxy, halo, CN, alkyl, perfluoroalkyl, cycloalkyl and cycloalkoxy, wherein R 3 and D may optionally be taken together with the atoms to which they are attached to form a 5 to 7-membered ring; R 4 is selected from the group consisting of alkyl, halo, polyfluoroalkyl, alkoxy, polyfluoroalkyloxy, CN and alkylthio; R 6 is independently selected from the group consisting of lower alkyl and lower cycloalkyl; and R 7 , R 7a and R 7b are independently selected from the group consisting of hydrogen, lower alkyl and lower cycloalkyl, wherein two R 7 and the atom to which they are attached may optionally form a heterocyclyl of 4 to 7 atoms, R 8 , R 9 , and R 9a , R 10 and R 11 are independently selected from the group consisting of hydrogen and alkyl; m is an integer from 1 to 2; and n is an integer from 1 to 4; or a pharmaceutically acceptable salt or a stereoisomer or a prodrug ester thereof.