Patent ID: 7419823

Claim:
A system for monitoring leukocyte migration comprising: a device including a housing having a base member and a top member defining a plurality of chambers therein, each of the plurality of chambers including: a first well region including at least one first well; a second well region including at least one second well; and a channel region including at least one channel connecting the first well region and the second well region with one another, wherein the at least one channel is formed as a through-hole in the top member; a first fluid stream having a first concentration of a first substance; and a second fluid stream having a second concentration of a second substance, wherein the first and second concentrations are different from one another and the first and second fluid streams are in fluid communication with at least one of the plurality of chambers, and wherein the first fluid stream and the second fluid stream flow adjacent and parallel to each other without mixing, to create a dynamic concentration gradient.