Patent ID: 8715670

Claim:
A human monoclonal antibody, or an antigen binding fragment thereof, that specifically binds to human vascular cell adhesion molecule-1 (VCAM-1) to inhibit the interaction between leukocytes and activated endothelial cells wherein the human monoclonal antibody comprises: (a) a heavy chain variable region that contains a heavy chain CDR1 as defined by SEQ ID NO. 2; a heavy chain CDR2 as defined by SEQ ID NO. 3; and a heavy chain CDR3 as defined by SEQ ID NO. 4, and a light chain variable region that contains a light chain CDR1 as defined by SEQ ID NO. 14; a light chain CDR2 as defined by SEQ ID NO. 15; and a light chain CDR3 as defined by SEQ ID NO. 16; (b) a heavy chain variable region that contains a heavy chain CDR1 as defined by SEQ ID NO. 6; a heavy chain CDR2 as defined by SEQ ID NO. 7; and a heavy chain CDR3 as defined by SEQ ID NO. 8, and a light chain variable region that contains a light chain CDR1 as defined by SEQ ID NO. 18; a light chain CDR2 as defined by SEQ ID NO. 19; and a light chain CDR3 as defined by SEQ ID NO. 20; (c) a heavy chain variable region that contains a heavy chain CDR1 as defined by SEQ ID NO. 10; a heavy chain CDR2 as defined by SEQ ID NO. 11; and a heavy chain CDR3 as defined by SEQ ID NO. 12, and a light chain variable region that contains a light chain CDR1 as defined by SEQ ID NO. 22; a light chain CDR2 as defined by SEQ ID NO. 23; and a light chain CDR3 as defined by SEQ ID NO. 24; or (d) an antigen binding fragment of (a), (b), or (c).