Patent ID: 8906844

Claim:
A peptide having the sequence: wherein: at least one of A, B, and Y is present and comprises a hydrophilic polymer; and wherein A, if present, comprises a hydrophilic polymer or is hydrogen, acyl, or an amino protecting group; B, if present, comprises a hydrophilic polymer or is an amino group, a hydroxyl group, or a carboxy protecting group; X 0 , if present, is an optionally derivatized amino acid or an analog thereof or an optionally derivatized peptide of 2-15 amino acids or an analog thereof; X 1 , if present, is an optionally derivatized amino acid or an analog thereof; X 2 , if present, is an amino acid or an analog thereof; X 3 is an amino acid or analog thereof that is capable of forming a bridge with X 10 , X 12 or X 13 , X 4 is an optionally derivatized amino acid or an analog thereof or an optionally derivatized peptide of 2 or 4 amino acids or an analog thereof; X 6 is a basic amino acid or an analog thereof, an aromatic amino acid or an analog thereof, or a basic aromatic amino acid or an analog thereof; X 7 is phenylalanine or an analog thereof; X 8 and X 9 are each independently chosen from glycine or an analog thereof, sarcosine or an analog thereof, aspartic acid or an analog thereof, a D -amino acid or an analog thereof, and α-aminoisobutyric acid or an analog thereof, or X 8 , when taken together with X 9 , forms a dipeptide analog; X 10 is an amino acid or an analog thereof, or X 10 , when taken together with X 9 , forms a dipeptide analog; X 11 is tyrosine or an analog thereof; X 12 is an optionally derivatized amino acid or an analog thereof; X 13 , if present, is an amino acid or an analog thereof; X 14 , if present, is an optionally derivatized amino acid or an analog thereof or an optionally derivatized peptide of 2-15 amino acids or an analog thereof; Y comprises a hydrophilic polymer; Z is a linker that attaches to each peptide monomer through A; B; the amino terminus or a side chain of X 0 , if X 0 is present; to the amino terminus or side chain of X 1 , if X 0 is absent; to the amino terminus or side chain of X 2 , if both X 0 and X 1 are absent; or to the amino terminus or side chain of X 3 , if X 0 , X 1 and X 2 are absent; or the carboxy terminus or a side chain of X 14 , if X 14 is present; to the carboxy terminus or a side chain of X 13 , if X 14 is absent; or to the carboxy terminus or a side chain of X 12 if both X 13 and X 14 are absent; m is an integer chosen from 1, 2, and 3; and n is an integer chosen from 1, 2, and 3; wherein: each A, B, X 0 , X 1 , X 2 , X 3 , X 4 , X 6 , X 7 , X 8 , X 9 , X1 0 , X 11 , X 12 , X 13 , and X 14 is chosen independently; and each monomer of the peptide ranges from 10 to 50 amino acids in length.