Patent ID: 8735061

Claim:
A method of treating a subject for cancer, based on measured expression levels of indicators of metastatic potential in a tumour tissue sample from said subject, said method comprising: (a) administering a non-aggressive treatment to said subject, if expression levels of indicators of moderate metastatic potential and indicators of high metastatic potential are less than or substantially equal to a control, (b) administering a moderately aggressive treatment to the subject, if expression levels of said indicators of moderate metastatic potential are elevated compared to said control, and said expression levels of said indicators of high metastatic potential are less than or equal to said control, or (c) administering a highly aggressive treatment to the subject, if expression levels of said indicators of moderate metastatic potential and said indicators of high metastatic potential are elevated compared to said control; wherein (i) the indicators of moderate metastatic potential are CAIX and VEGF-C, and optionally one or more indicators selected from the group consisting of EFNA5, EPHB2, TGF-β3, and PDK3, and (ii) the indicators of high metastatic potential are CAXII, KRT14, and TNC, and optionally HIF-1α.