Patent ID: 8735331

Claim:
A library of antibody molecules, wherein each antibody molecule comprises a VH domain consisting of VH CDR1, CDR2 and CDR3 and framework regions, wherein the VH domain amino acid sequence corresponds to a human germline antibody heavy chain sequence in which the residue at position 52 in VH CDR2 is mutated from germline and wherein residues in VH CDR3 are variably mutated, said VH domain consisting of the sequence SEQ ID NO: 22- R 52 - SEQ ID NO: 23- R 95 -R 96 -R 97 -R 98 -R 99 -R 100 -R 100A - SEQ ID NO: 24 wherein R 52 is Asn or Tyr; R 95 is an amino acid residue; R 96 is an amino acid residue; R 97 is an amino acid residue; R 98 is an amino acid residue; R 99 is an amino acid residue or is not present; R 100 is an amino acid residue or is not present; and R 100A is an amino acid residue or is not present.