Patent ID: 7662552

Claim:
A method for determining the cataract susceptibility in a subject comprising the steps of: a) obtaining a biological sample from said subject, said biological sample comprising nucleic acids from the subject; b) detecting in said nucleic acids the subject's gamma-S crystalline (CRYGS) gene and determining the nucleic acid sequence of the subject's gamma-S crystalline (CRYGS) gene; c) detecting in the nucleic acid sequence of the subject's gamma-S crystalline (CRYGS) gene homozygous nucleotide content comprising: i) a C at position 424 of SEQ ID NO: 30 resulting from a G to C change at position 76 of intron 1; ii) a G at position 357 of SEQ ID No: 31 resulting from an A to G change at position 11 of intron 2; iii) the sequence ATGTATGT, wherein the first position of the sequence is at position 366 of SEQ ID NO: 31, resulting from a repeat of the ATGT sequence at positions 20-23 of intron 2; and iv) an A at position 1398 of SEQ ID NO: 31 resulting from a G to A change at position 225 of exon 3; wherein said subject is a mouse and said nucleoticle content indicates an increased cataract susceptibility.