Patent ID: 7399845

Claim:
A bicyclic nucleoside having the formula: wherein: Bx is a heterocyclic base moiety; T 1 is H or a hydroxyl protecting group; T 2 is H, a hydroxyl protecting group or a reactive phosphorus group; Z is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl, substituted C 2 -C 6 alkynyl, acyl, substituted acyl, substituted amide, thiol or substituted thio; and wherein each of the substituted groups, is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, oxo, hydroxyl, OJ 1 , NJ 1 J 2 , SJ 1 , N 3 , OC(═X)J 1 , OC(═X)NJ 1 J 2 , NJ 3 C(═X)NJ 1 J 2 and CN, wherein each J 1 , J 2 and J 3 is, independently, H or C 1 -C 6 alkyl, and X is O, S or NJ 1 .