Patent ID: 8404869

Claim:
A pharmaceutical composition, comprising: (a) a therapeutically effective amount of a compound represented by Formula 1: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently hydrogen, halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkene, C 1 -C 6 alkyloxy, C 3 -C 8 cycloalkyl, or heterocycloalkyl, C 4 -C 10 aryl or heteroaryl, or two substituents thereof may be taken together to form a cyclic structure or form a double bond; R 9 and R 10 are each independently hydrogen, halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkene, C 1 -C 6 alkyloxy, C 3 -C 8 cycloalkyl, or heterocycloalkyl, C 4 -C 10 aryl or heteroaryl; R 11 , R 12 , R 13 , R 14 , R 15 and R 16 are each independently hydrogen, halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkene, C 1 -C 6 alkyloxy, C 3 -C 8 cycloalkyl, or heterocycloalkyl, C 4 -C 10 aryl or heteroaryl, or two substituents thereof may be taken together to form a cyclic structure or form a double bond; m and n are each independently 0 or 1, when m or n is 0, carbon atoms adjacent to m or n may form a cyclic structure via a direct bond; with the proviso that (i) when m is 1, n is 0, carbon atoms adjacent to m or n form a cyclic structure via a direct bond, R 9 , R 10 and R 11 are hydrogen, R 12 and R 13 are hydrogen or are taken together to form a double bond, and R 1 to R 6 are hydrogen and R 7 and R 8 are methyl, R 14 is not methyl, and (ii) when m is 1, n is 0, carbon atoms adjacent to m or n form a cyclic structure via a direct bond, R 9 , R 10 and R 11 are hydrogen, R 12 and R 13 are hydrogen or are taken together to form a double bond, R 1 , R 3 and R 5 are hydrogen, R 2 , R 4 , R 6 and R 8 are taken together to form a double bond, and R 7 is methyl, R 14 is not methyl; and (b) a pharmaceutically acceptable carrier, a diluent, an excipient, or any combination thereof.