Patent ID: 7101865

Claim:
A compound of Formula I, and pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof: wherein R 1 is selected from the group consisting of OH, OC 1-4 alkyl, and halo; R 2 is selected from the group consisting of H, OH, OC 1-4 alkyl, and halo; each R 3 are either both H or together form ═CH 2 ; R 4 is C 1-4 alkyl; represents a single or a double bond; each R 5 can be the same or different and is selected from the group consisting of hydrogen, halo and C 1-4 alkyl or each R 5 can be taken together to form a C 3-6 cycloalkyl ring; R 6 is selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, aryl and heteroaryl, wherein each of C 1-6 alkyl, C 3-6 cycloalkyl, aryl and heteroaryl are either unsubstituted or substituted with 1–5 substituents independently selected from the group consisting of C 1-4 alkyl, OC 1-4 alkyl, CF 3 , NO 2 and halo; R 7 is selected from the group consisting of H, C 1-6 alkyl and C(O)R 8 ; and R 8 is selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, aryl-C 1-4 alkyl, aryl and heteroaryl, wherein each of C 1-6 alkyl, C 3-6 cycloalkyl, aryl and heteroaryl are either unsubstituted or substituted with 1–5 substituents independently selected from the group consisting of C 1-4 alkyl, OC 1-4 alkyl, CF 3 , NO 2 and halo, provided that when there is a double bond between C22 and C23, there is only one R 5 group attached to C23 and R 5 is selected from the group consisting of hydrogen, halo and C 1-4 alkyl, wherein the prodrug is a phenyl ester, aliphatic (C 8–C 24 ) ester, acyloxymethyl ester, carbamate or amino acid ester formed from an available hydroxy, thiol, amino or carboxy group of said compound of Formula I.