Patent ID: 8188101

Claim:
A compound or pharmaceutically acceptable salt thereof of formula (Ia) wherein: R 1 is selected from phenyl substituted in the para position by a heteroaryl group and wherein the phenyl group and the heteroaryl group are optionally and independently substituted by one to three R′ groups; R 2 is Y—R 7 ; Y is —C(R 12 )(R 13 )—, —N(R 8 )—, —O—, —C(R 12 )(R 13 )—N(R 8 )—, —N(R 8 )—C(R 12 )(R 13 )—, —C(R 12 )(R 13 )—O—, or —O—C(R 12 )(R 13 )—; R′ is selected from halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy; R 8 is selected from hydrogen, C 1-6 alkyl, halogenated C 1-6 alkyl and C 3-6 carbocyclyl, wherein said C 1-6 alkyl, is optionally and independently substituted with one to three substituents selected from cyano, hydroxy or heterocyclyl; R 7 is selected from hydrogen, aryl, heteroaryl, C 1-4 alkylaryl, C 1-4 alkylheteroaryl, C 1 - 4 alkylheterocyclyl, halogenated C 1-6 alkyl, C 1-6 alkyl and C 3-6 carbocyclyl, wherein said aryl, heteroaryl, C 1-6 alkyl or carbocyclyl is optionally and independently substituted with one to three hydroxy, alkoxy, cyano, hydroxyalkyl, C(O)C 1-6 alkyl or R′ groups, wherein said C(O)C 1 - 6 alkyl is optionally substituted with hydroxy; or R 8 and R 7 may, when Y is NR 8 , optionally form together with the nitrogen atom a saturated, partially saturated or unsaturated ring system containing one nitrogen atom as a heteroatom, wherein said ring system is optionally and independently substituted by one to three R′ groups R 12 and R 13 are independently selected from C 1-4 alkyl, halogenated C 1-4 alkyl, C 1-4 alkoxy, halogenated C 1-4 alkoxy; Z is N—(R 3b ); R 3b is selected from hydrogen, C 1-6 alkyl, cyano substituted C 1-6 alkyl, halogenated C 1-6 alkyl, C 1-6 alkanoyl, hydroxy substituted C 1-6 alkanoyl, dialkylamino substituted C 1-6 alkanoyl, C 1-6 alkoxy substituted C 1-6 alkanoyl, C 3-6 carbocyclyl-carbonyl, (C 1-6 alkyl) 2 carbamoyl, C 1-6 alkylsulfonyl, and C 1-6 alkoxycarbonyl; provided that compounds according to formula (Ia), wherein Y is NR 8 , Z is N—(R 3b ), R 8 is hydrogen, alkyl or cycloalkyl, and R 7 is arylalkyl are excluded.