Patent ID: 7856319

Claim:
A method for diagnosis of alcoholic steato-hepatitis in a patient or from a serum or plasma sample of a patient, comprising the steps of: a) studying 7 biochemical markers by measuring the values of their concentration in the serum or plasma of said patient, wherein said markers are: ApoA1 (apolipoprotein A1), ALT (alanine aminotransferase), AST (aspartate aminotransferase), alpha.2-macroglobulin, GGT (gammaglutamyl transpeptidase), total bilirubin, and haptoglobin; b) combining said values through a logistic function including said markers in order to obtain an end value, wherein said logistic function further takes the age and gender of the patient into account and is obtained through the following method: i) classification of a cohort of patients in different groups according to the extent of their disease; ii) identification of factors which differ significantly between these groups by unidimensional analysis; iii) logistic regression analysis to assess the independent discriminative value of markers for the diagnosis of alcoholic steato-hepatitis; iv) construction of the logistic function by combination of these identified independent factors; and c) analyzing said end value of said logistic function in order to determine the presence or absence of alcoholic steato-hepatitis in said patient.