Patent ID: 7001899

Claim:
A compound or its enantiomeric or diasteriomeric form or a pharmaceutically acceptable salt thereof, said compound having the formula: wherein each W is hydrogen of a unit having the formula —(L 2 ) j —R 2 , the index j is 0 or 1; wherein R is a ring chosen from: i) substituted or unsubstituted C 3 –C 10 non-aromatic carbocyclic; ii) substituted or unsubstituted C 6 –C 10 aryl; iii) substituted or unsubstituted C 1 –C 10 heterocyclic; and iv) substituted or unsubstituted C 1 –C 10 heteroaryl; R 1 is a cysteine trap; each R 3 is independently selected from the group consisting of: i) hydrogen; ii) a hydrocarbyl unit having the formula: —[C(R 3 ) 2 ] p (CH═CH) q R 3 ; iii) —C(═Z)R 3 ; iv) —C(═Z)AR 3 ; v) —C(═Z)[C(R 3 ) 2 ] p (CH═CH) q R 3 ; vi) —C(═Z)N(R 3 ) 2; vii) —C(═Z)NR 3 N(R 3 ) 2 ; viii) —CN; xix) —CF 3 ; x) —N(R 3 ) 2 ; xi) —NR 3 CN; xii) —NR 3 C(═Z)R 3 ; xiii) —NR 3 C(═Z)N(R 3 ) 2 ; xiv) —NHN(R 3 ) 2 ; xv) —NHOR 3 ; xvi) —NO 2 ; xvii) —OR 3 ; xviii) —OCF 3 ; xix) —F, —Cl, —Br, or —I; —xx) —SO 3 M; —xxi) —OSO 3 M; xxii) —SO 2 N(R 3 ) 2 ; xxiii) —SO 2 R 3 ; xxiv) —P(O)(OR 3 )R 3 ; xxv) —P(O)(OR 3 ) 2 ; xxvi) and mixtures thereof; each R 3 is independently hydrogen, substituted or unsubstituted C 1 –C 20 linear, branched, or cyclic alkyl, substituted or unsubstituted C 6 –C 20 aryl, C 1 –C 20 substituted or unsubstituted heterocyclic, C 1 –C 20 substituted or unsubstituted heteroaryl; Z is O, S, or NR 3 ; M is hydrogen, or a salt forming cation; the index p is from 0 to 12; the index q is from 0 to 12; L, L 1 , and L 2 are each independently a linking group having the formula: T, T 1 , and T 2 are each independently selected from the group consisting of: i) —NR 6 —; ii) —O—; iii) —S(O) 2 —; iv) —NR 6 S(O) 2 —; and v) —S(O) 2 NR 6 —; R 6 is hydrogen, substituted or unsubstituted C 1 –C 10 linear, branched, or cyclic alkyl, C 6 –C 10 aryl, and C 7 –C 12 alkylenearyl; the indices w, w 1 , and w 2 are each independently 0 or 1; R 4a , R 4b , R 5a , and R 5b are each independently: i) hydrogen; ii) C 1 –C 4 linear, branched, and cyclic alkyl; iii) R 4a and R 4b or R 5a , and R 5b can be taken together to form a carbonyl unit; and iv) two R 3a or two R 3b units from adjacent carbon atoms or two R 4a or two R 4b units from adjacent carbon atoms can be taken together to form a double bond; the index m is from 0 to 5; the index n is from 0 to 5.