Patent ID: 7384955

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof: wherein R 1 is optionally substituted C 1-10 hydrocarbyl; optionally substituted C 1-10 acyl; optionally substituted C 4-8 heteroaryl-C(═O)—; R 4 R 5 N—C 1-6 alkyl; R 4 R 5 NC(═O)—C 1-6 alkyl; R 4 O—C 1-6 alkyl; R 4 OC(═O)—C 1-6 alkyl; R 4 C(═O)—C 1-6 alkyl; R 4 C(═O)NR 4 —C 1-6 alkyl; R 4 R 5 NSO 2 —C 1-6 alkyl; R 4 CSO 2 N(R 5 )—C 1-6 alkyl; R 4 R 5 NC(═O)N(R 6 )—C 1-6 alkyl; R 4 R 5 NSO 2 N(R 6 )—C 1-6 alkyl; optionally substituted aryl-C 1-6 alkyl; optionally substituted aryl-C(═O)—C 1-6 alkyl; optionally substituted heterocyclyl-C 1-6 alkyl; optionally substituted heterocyclyl-C(═O)—C 1-6 alkyl; and C 1-10 hydrocarbylamino; wherein R 4 , R 5 and R 6 are independently selected from —H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or a divalent C 1-6 group that together with another divalent C 1-6 group forms a portion of a ring; X is selected from the group consisting of —NR 6 —, —CH 2 —CH 2 —, —CH═CH—, —O—, —C(R 8 )(R 9 )—, and —S(O) q —, wherein a is 0, 1 or 2, wherein R 8 and R 9 are independently C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, —OH, or —H; at most one of R 8 and R 9 is —OH; Ar is a C 4-12 divalent aromatic group; R 2 is optionally substituted C 1-6 hydrocarbyl, optionally substituted C 6-10 aryl, or optionally substituted C 3-6 heteroaryl; R 3 is selected from: wherein R 7 is selected from —H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted C 6-10 aryl, or optionally substituted C 3-6 heteroaryl; R 10 , R 11 , R 12 and R 13 are independently selected from optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted C 6-10 aryl, or optionally substituted C 3-6 heteroaryl; and R a and R b are —R, —NO 2 , —OR, —Cl, —Br, —I, —F, —OF 3 , —C(═O)R, —C(═O)OH, —NH 2 , —SH, —NHR, —NR 2 , —SR, —SO 3 H, —SO 2 R, —S(═O)R, —CN, —OH, —C(═O)OR, or —NRC(═O)R, wherein R is independently —H or C 1-6 hydrocarbyl.