Patent ID: 8574861

Claim:
A method for identifying putative agents for the treatment of Alzheimer's disease, said method comprising: (a) contacting an agent with a phosphorylated substrate and with a protein phosphatase 1 E having SEQ ID NO:1 or SEQ ID NO:2, (b) measuring the enzymatic activity of said protein phosphatase 1 E having SEQ ID NO:1 or SEQ ID NO:2, (c) comparing the enzymatic activity measured in step (b) with the enzymatic activity of a protein phosphatase 1 E having SEQ ID NO:1 or SEQ ID NO:2 not contacted with said agent, (d) identifying agents that decrease the enzymatic activity of said protein phosphatase 1 E having SEQ ID NO:1 or SEQ ID NO:2 as putative agents for the treatment of Alzheimer's disease.