Patent ID: 7167802

Claim:
A method for identifying an agent that interacts with MAP Kinase Activated Protein Kinase 2 (MK2), comprising: providing a crystallized MK2; determining the three dimensional structure of MK2; generating a three dimensional model of MK2 using the structural coordinates of (i) molecules A, B, C, or D of MK2 according to FIGS. 2 through 2 A- 204 , (ii) a portion of molecules A, B, C, or D of MK2 according to FIGS. 2 through 2 A- 204 , (iii) molecule A of MK2 according to FIGS. 3 through 3 A- 40 , or (iv) a portion of molecule A according to FIGS. 3 through 3 A- 40 , ± a root mean square deviation from the backbone atoms of said amino acids of not more than 1.5 Å; identifying a putative agent that interacts with MK2 by performing computer fitting analysis of the putative agent with said three dimensional model; and obtaining the agent.