Patent ID: 7199137

Claim:
A compound of formula (I): wherein X is O, CH 2 , CO, S or NH, or the moiety X—R 1 is hydrogen; Y 1 and Y 2 are CH; R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, or arylC 1-6 alkyl, any of which may be optionally substituted; in addition, when X is CH 2 then R 1 may be hydroxy or C 1-6 alkoxy which may be optionally substituted; R 2 is H, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, C 5-7 cycloalkenyl, or aryl, any of which may be optionally substituted; Ar is a group of the formula a) or b): wherein A represents a fused 5-membered carbocyclic ring which ring is optionally substituted by up to 2 substituents selected from halogen, C 1-6 alkyl, hydroxy, C 1-6 alkoxy and keto; R 3 and R 4 are independently selected from hydrogen, halogen, C 14 alkyl, aryl, aryl C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, haloC 1-6 alkyl, arylC 1-6 alkoxy, hydroxy, nitro, cyano, azido, amino, mono- and di-N-C 1-6 alkylamino, acylamino, arylcarbonylamino, acyloxy, carboxy, carboxy salts, carbamoyl, mono- and di-N-C 1-6 alkylcarbamoyl, C 1-6 alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkylamidino, sulphonylamino, aminosulphonyl, C 1-6 alkylthio, C 1-6 alkylsulphinyl and C 1-6 alkylsulphonyl; R 15 is O or N—OH; one of X 1 and X 2 is N and the other is NR 6 wherein R 6 is hydrogen or C 1-6 alkyl; wherein the optional substituents for alkyl, alkoxy, alkenyl, cycloalkyl and cycloalkenyl groups are selected from aryl, C 1-6 alkoxy, C 1-6 alkylthio, arylC 1-6 alkoxy, aryl C 1-6 alkylthio, amino, mono- or di-Ci 1-6 alkylamino, aminosulphonyl, cycloalkyl, cycloalkenyl, carboxy, amide, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkylamidino, C 1-6 acyloxy, hydroxy, halogen, cyano and any combinations thereof; wherein the aryl groups may be optionally substituted by a substituent selected from halogen, hydroxy, C 1-6 alkyl, aryl, arylC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, haloC 1-6 alkyl, arylC 1-6 alkoxy, nitro, cyano, azido, amino, mono- and di-N-C 1-6 alkylamino, acylamino, arylcarbonylamino, acyloxy, carboxy, carboxy salts, carbamoyl, mono- and di-N-C 1-6 alkylcarbamoyl, C 1-6 alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkylamidino, urea, carbamate, acyl, sulphonylamino, aminosulphonyl, C 1-6 alkylthio, C 1-6 alkylsulphinyl, C 1-6 alkylsulphonyl, and any combination thereof; or a pharmaceutically acceptable salt thereof.