Patent ID: 6844358

Claim:
A compound of formula I having the structure wherein A is O, or S; B is —(CH 2 ) m —, —CH(OH)—, or carbonyl; R 1 is hydrogen, nitro, halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or trifluoromethyl; R 2 is Het-alkyl wherein the alkyl moiety is 1-6 carbon atoms; Het is R 2a is alkylene of 1-3 carbon atoms; G is oxygen, sulfur, or nitrogen; R 3 , R 4 are each, independently, hydrogen, halogen, alkyl of 1-3 carbon atoms, aryl of 6-10 carbon atoms or a heterocyclic ring of 5 to 7 ring atom containing 1 to 3 heteroatoms selected from oxygen, nitrogen, sulfur; R 5 is hydrogen, alkyl of 1-6 carbon atoms, —CH(R 7 )R 8 , —C(CH 2 ) n CO 2 R 9 , —C(CH 3 ) 2 CO 2 R 9 , —CH(R 7 )(CH 2 ) n CO 2 R 9 , or CH(R 7 )C 6 H 4 CO 2 R 9 ; R 6 is hydrogen, halogen, alkyl of 1-6 carbon atoms, or —OR 5 ; m=1-6; n=1-6; R 7 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms; R 8 is —CO 2 R 10 , —CONHR 10 , tetrazole, or —PO 3 ; R 9 and R 10 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms; or a pharmaceutically acceptable salt thereof.