Patent ID: 8597239

Claim:
A method of extravasated delivery of a therapeutic and/or diagnostic agent to tissue, comprising the steps of: inserting a catheter into a bodily cavity, said catheter comprising a first balloon; a second balloon; a third balloon positioned between the first and second balloons and having a wall with an abrasive outer surface; and at least one additional balloon positioned between the first and second balloons and having a wall with an abrasive outer surface; inflating the first and second balloons to create a chamber between the first balloon and the second balloon, wherein the boundaries of the chamber are defined by an inner surface of the cavity wall and the catheter; stimulating a flow of blood cells by inflating the third balloon such that the abrasive outer surface abrades tissue in the bodily cavity; and delivering the therapeutic and/or diagnostic agent to the chamber and external of the third balloon after stimulating the flow of blood cells.