Patent ID: 8889827

Claim:
A method of treatment of pain in a subject in need of such treatment, wherein, the method comprising administering to the subject a peptide derivative of formula (I): ζ-AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -OH, (I) (SEQ ID NO: 44) wherein: ζ is hydrogen atom, tyrosine, Y-[linker]- or a Zn chelating group, AA 1 is Q or Glp, AA 2 is K, R or H, AA 3 is Y, G, N, F or F(X), AA 4 is P, S or S(OAlk), AA 5 is K or R, Y-[linker]- meaning Tyr-[NH—(CH 2 ) n′ —CO]—, wherein n′ is an integer between 1 and 20, F(X) meaning a phenylalanine, the phenyl group of which is substituted by one or more halogen atoms, S(OAlk) meaning a serine, the hydroxyl group of which is substituted by a linear or branched alkanoyl group having from 1 to 20 carbon atoms, said AA 1 , AA 2 , AA 3 , AA 4 , and AA 5 are independently either in the L-configuration or D-configuration, and any one of AA 1 , AA 2 , AA 3 , AA 4 , and AA 5 is optionally a β aminoacid, an aza-aminoacid or a β-aza-aminoacid; wherein if the peptide derivative comprises a cysteine, said peptide derivative is optionally a dimer, with the proviso that the peptide is not QRFSR (SEQ ID NO:1), QHNPR (SEQ ID NO:4), QRGPR (SEQ ID NO:3), YQRFSR (SEQ ID NO:9), GlpRFSR (SEQ ID NO:26), CQRFSR (SEQ ID NO:13), GlpHNPK (SEQ ID NO:55) and GlpHNPR (SEQ ID NO:56) in an effective amount to treat pain, wherein the treatment inhibits an activity of a membrane metallo-ectopeptidase selected from the group consisting of NEP and AP-N.