Patent ID: 7118919

Claim:
A method of diagnosing insulin resistance in a subject, said method comprising: a) collecting a first breath sample from said subject in a first breath collection container; b) administering 13 C-enriched glucose to said subject; c) collecting a second breath sample from said subject in a second breath container at a time point after administration of said 13 C-enriched glucose; d) measuring the 13 CO 2 in each of said first and second breath samples; and e) comparing the amount of 13 CO 2 in said second breath sample with the amount of 13 CO 2 in said first breath sample, wherein the presence of less 13 CO 2 in said second breath sample compared to normal control comparison values indicates insulin resistance in the subject wherein said comparison is made by choosing a cutoff of receiver operated characteristics (ROC) values wherein the sensitivity and specificity are such as to maximize diagnostic accuracy.