Patent ID: 8852887

Claim:
An isolated nucleic acid that encodes an antibody that binds to human TWEAK, comprising: a) a variable heavy chain comprising CDR1H with the amino acid sequence of SEQ ID NO:22, CDR2H with the amino acid sequence of SEQ ID NO:23, CDR3H with the amino acid sequence of SEQ ID NO:24, and a variable light chain comprising CDR1L with the amino acid sequence of SEQ ID NO:18, CDR2L with the amino acid sequence of SEQ ID NO:19, and CDR3L with the amino acid sequence of SEQ ID NO:20; or b) a variable heavy chain comprising CDR1H with the amino acid sequence of SEQ ID NO:22, CDR2H with the amino acid sequence of SEQ ID NO:74, CDR3H with the amino acid sequence of SEQ ID NO:24, and a variable light chain comprising CDR1L with the amino acid sequence of SEQ ID NO:18, CDR1L with the amino acid sequence of SEQ ID NO:19, and CDR3L of SEQ ID NO:20; or c) a variable heavy chain comprising CDR1H with the amino acid sequence of SEQ ID NO:22, CDR2H with the amino acid sequence of SEQ ID NO:75, CDR3H with the amino acid sequence of SEQ ID NO:24, and a variable light chain comprising CDR1L with the amino acid sequence of SEQ ID NO:18, CDR1L with the amino acid sequence of SEQ ID NO:19, and CDR3L with the amino acid sequence of SEQ ID NO:20.