Patent ID: 7351711

Claim:
A compound of Formula (I): wherein: R is selected from the group consisting of hetercyclyl and heteroaryl; R 1 is one to two substituents selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, —NR A R B , and halogen; wherein alkyl and alkoxy are optionally substituted on a terminal carbon one to three substituents independently selected from the group halogen, hydroxy, and —NR A R B ; wherein R A and R B are substituents independently selected from hydrogen or C 1-6 alkyl; R 2 is one to two substituents independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 alkoxy, —NR C R D , hydroxy, and halogen; wherein alkyl, alkenyl, alkynyl, and alkoxy are optionally substituted on a terminal carbon with one to three substituents independently selected from the group halogen, hydroxy, C 1-4 alkoxy, and —NR C R D ; wherein R C and R D are substituents independently selected from hydrogen or C 1-6 alkyl; R C and R D are optionally taken together with the atoms to which they are attached to form a five to seven membered monocyclic ring; Z is selected from the group consisting of —CH 2 — and —CH—; A is selected from the group consisting of aryl, —CH(CH 2 ) 1-3 —, and —(CH 2 ) 1-3 —; provided that when A is —CH(CH 2 ) 1-2 — and Z is —CH— then a double bond is formed between A and Z; B is —NH— when optionally present; m and n are integers from 1 to 3; X is selected from the group consisting of O, S, and two hydrogen atoms; U is independently selected from the group consisting of —CH—, N, and S, provided that no more than one U represents S or N; and that U can only be S when W is not present; W is selected from the group consisting of —CH— and N when optionally present; and enantiomers, diastereomers, tautomers, or pharmaceutically acceptable salts thereof.