Patent ID: 8598180

Claim:
A pharmaceutical composition comprising a compound having the following formula (I): wherein: (a) X is CH or N; (b) R 1 is hydrogen, alkyl, aralkyl, heteroaralkyl, alkenyl, aralkenyl, heteroaralkenyl, aryl, or heteroaryl; (c) R 2 is hydrogen, alkyl, aralkyl, aryl, or heteroaryl; (d) R 2 , is hydrogen unless R 2 is methyl, in which case R 2 , is also methyl; (e) R 3 has the following formula (III): wherein: (i) R 4 is hydrogen, alkyl, halo, hydroxy, alkoxy, cyano, nitro, perfluoroalkyl, perfluoroalkoxy, or hydroxymethyl; (ii) R 5 is hydrogen, alkyl, halo, alkoxy, cyano, nitro, perfluoroalkyl, perfluoroalkoxy, amino, aminocarbonyl, aminosulfonyl, or hydroxymethyl; (iii) R 6 is alkyl, halo, alkoxy, perfluoroalkyl, perfluoroalkoxy, or nitro; (iv) R 4 and R 5 when taken together can form a 5 or 6 membered ring and can contain one or more heteroatoms; (v) R 5 and R 6 when taken together can form a 5 or 6 membered ring and can contain one or more heteroatoms; (f) L is selected from the group consisting of —(CH 2 ) m —, where m is an integer from 1 to 6, and an alkyl substituted hydrocarbyl moiety of the formula (IV): wherein: (i) n is 0, 1 or 2; (ii) R7 and R8 are hydrogen, methyl or ethyl; (iii) R9 and R9′ are hydrogen, methyl or ethyl; (iv) if n is 1 and R7 or R8 is methyl or ethyl, then R9 and R9′ are hydrogen; (v) if n is 1 and R7 and R8 are hydrogen, then R9 and R9′ are methyl or ethyl; and (vi) if n is 2, then R9 and R9′ are hydrogen and one or both of R7 and R8 are methyl or ethyl; and pharmaceutically acceptable salts and esters thereof.