Patent ID: 8637521

Claim:
A compound of Formula I: wherein R 3 is selected from the group consisting of H, OH, OC 1-6 alkyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , NHNH 2 and OY, where Y is a cation selected from a lithium, sodium, potassium, calcium, magnesium, barium, zinc, aliphatic ammonium, aromatic ammonium and NH 4 + cation; R 4 is 1 to 4 substituents independently selected from the group consisting of H, halo, OH, OC 1-6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkenyloxy, NH 2 , NH(C 1-6 alkyl), N(C 1-6 alkyl)(C 1-6 alkyl), CN, CF 3 , OCF 3 , NO 2 , C(O)C 1-6 alkyl, C(O)OC 1-6 alkyl, SO 2 C 1-6 alkyl, SO 2 NH 2 , SO 2 NHC 1-6 alkyl, phenyl and C 1-6 alkylenephenyl; L 1 and L 2 are each independently a linker group selected from the group consisting of a single bond, —C(O)—, —C(O)NR 2 —, —NR 2 C(O)—, —NR 2 —, —C(O)—O—, —OC(O)—, —S—S—, —SO 2 NR 2 —, —NR 2 SO 2 —, —S— and —O—; R 2 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkylenearyl, C(O)C 1-6 alkyl, C(O)aryl, SO 2 C 1-6 alkyl and SO 2 aryl; R 5 is H or C 1-6 alkyl; * is the L or D configuration or mixtures thereof; ** is the L or D configuration or mixtures thereof; m is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50; n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50; and D is selected from the group consisting of H, C 1-6 alkyl, a side chain of an amino acid, and a biologically active moiety; or a pharmaceutically acceptable salt, or ester or amide prodrug thereof.