Patent ID: 8680062

Claim:
An oligomeric compound having the general Formula I: wherein: n is an integer from 3 to 20; each of X 1 -Xn is independently a residue of a building block of the oligomer, wherein said residue or building block is represented by the general structure: -J-O—P(═O)(Ra)—O—; wherein: J is alkyl, cycloalkyl, aryl, ether, amide or carboxy; Ra is hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, phenyl, aryl, cycloalkyl, thiohydroxy, thioalkoxy or thiaryloxy; each of L 1 -Ln is independently a first linking group or absent, wherein said first linking group is methylene, substituted or unsubstituted saturated or unsaturated C 4 -C 10 hydrocarbon chain, or substituted or unsubstituted saturated or unsaturated C 4 -C 10 hydrocarbon chain interrupted by at least one heteroatom selected from oxygen, nitrogen and sulfur; each of A 1 -An is independently a second linking group attached to J or absent, wherein said second linking group is methylene, substituted or unsubstituted saturated or unsaturated C 2 -C 10 hydrocarbon chain, or substituted or unsubstituted saturated or unsaturated C 2 -C 10 hydrocarbon chain interrupted by at least one heteroatom selected from oxygen, nitrogen and sulfur; each of Y 1 -Yn is independently a delivering group, wherein said delivering group is amine; guanidine, histidine or imidazole; each of B 1 and B 2 is independently a spacer or absent, wherein said spacer is allylamine, diaminoethane, diaminohexane, substituted or unsubstituted saturated or unsaturated C 2 -C 10 hydrocarbon chain, or substituted or unsubstituted saturated or unsaturated C 2 -C 10 hydrocarbon chain interrupted by at least one heteroatom selected from oxygen, nitrogen and sulfur; and each of Z 1 and Z 2 is independently a reactive group capable of binding a biologically active moiety or hydrogen, provided that at least one of Z 1 and Z 2 is amine, halide, hydroxy, amide, amide, carboxy, thiol, thioamide, thiocarboxy, alkoxy, thioalkoxy, aryloxy, thioaryloxy, hydrazine, hydrazide, phosphoramidite, phosphate, phosphonate, phosphine or any combination thereof; and wherein Z 1 , Z 2 and/or Y 1 -Y n can each independently be protected by an amine protecting group selected from formyl, acetyl, trifluoroacetyl, benzyl, benzyloxycarbonyl (“CBZ”), tert-butoxycarbonyl (“Boc”), trimethylsilyl (“TMS”), 2-trimethylsilylethanesulfonyl (“SES”), trityl and substituted trityl groups, allyloxycarbonyl, 9-fluorenylmethyloxycarbonyl (“FMOC”), nitro-veratryloxycarbonyl (“NVOC”); hydroxy protecting groups selected from benzyl, and trityl ethers as well as alkyl ethers, tetrahydropyranyl ethers, trialkylsilyl ethers, allyl ethers, monomethoxytrityl and dimethoxytrityl.