Patent ID: 7297796

Claim:
A compound of formula I′: wherein: R 1 is H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroaralkyl, F, Cl, or Br; R 2 and R 3 are each independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl, provided that at least one of R 2 and R 3 is other than H; or R 2 and R 3 when taken together with the nitrogen atom to which they are attached, form a 3- to 8-membered heterocycloalkyl ring, wherein 1 or 2 of the heterocycloalkyl ring carbon atoms independently may each be optionally replaced by —O—, —S—, —N(R 9 )—, —N(R 10 )—C(═O)—, or —C(═O)—N(R 10 )—; R 4 is H or alkyl; R 5 is: R a , R b , and R c are each independently H or alkyl; R d and R e taken together with the carbon atom to which they are attached form a carbocyclic ring; R 6 , R 7 , and R 8 are each independently H, F, Cl, Br, or alkyl; R 9 is H, alkyl, aryl, —C(═O)—R 11 , —C(═O)—OR 11 , —[C(R 11 )(R 11 )] s —C(═O)—OR 11 , —SO 2 R 11 , or —C(═O)N(R 11 )R 11 ; R 10 is H, alkyl, or aryl; each R 11 is independently H or alkyl; r is 0, 1, 2, or 3; and s is 1, 2, 3, or 4; provided that: (1) when R d and R e taken together with the carbon atom to which they are attached form a monocyclic carbocyclic ring, then R c is alkyl; and (2) when R 5 is: then R 2 and R 3 are taken together with the nitrogen atom to which they are attached to form a 3- to 8-membered heterocycloalkyl ring; or a pharmaceutically acceptable salt thereof.