Patent ID: 8168218

Claim:
A press-coated tablet comprising a core containing 5 mg of prednisone and a coating around the core, said core being disposed within said coating such that the coating thickness about an axis (X-Y) is thicker than the coating about an axis (A-B) orthogonal to (X-Y), wherein the thickness of the coating about the axis (X-Y) is selected such that the coating ruptures upon immersion in an aqueous medium after a period of between about 2 to about 6 hours to release the drug, wherein coating material about the (X-Y) axis is relatively less dense than the coating material disposed about the (A-B) axis and the coating material about the (X-Y) axis is more permissive towards ingress of aqueous media than the coating material disposed about the axis (A-B), and wherein the axis (A-B) is the axis of the direction of movement of the punch used in the press-coating of the tablet: said tablet comprising the following ingredients Core of 5 mg prednisone tablet: Prednisone 8.33% as a percentage by weight in said core; Lactose monohydrate 64.47% as a percentage by weight in said core; Povidone 6.67% as a percentage by weight in said core; Croscarmellose sodium 18.33% as a percentage by weight in said core; Red ferric oxide 0.5% as a percentage by weight in said core; Magnesium stearate Vegetable origin 1.0% as a percentage by weight in said core; Colloidal silicon dioxide 0.5% as a percentage by weight in said core; Coating: Dibasic calcium phosphate dihydrate 50% as a percentage by weight in said coating; Glyceryl behenate 40% as a percentage by weight in said coating; Povidone 8.40% as a percentage by weight in said coating; Yellow ferric oxide 0.1% as a percentage by weight in said coating; Magnesium stearate Vegetable origin 1.0% as a percentage by weight in said coating; Colloidal silicon dioxide 0.5% as a percentage by weight in said coating.