Patent ID: 7288542

Claim:
A compound according to formula I wherein; R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, acylamino, nitro and cyano; R 5 is aryl or heteroaryl radical said heteroaryl radical selected from the group consisting of pyridinyl, pyridine N-oxide, indole, indole N-oxide, quinoline, quinoline N-oxide, pyrimidinyl, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl radicals are optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 sulfonyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, hydroxy, halogen, amino, C 1-6 alkylamino, C 1-6 dialkylamino, acylamino, acyl, C 1-6 alkoxycarbonyl, carbamoyl, C 1-6 N-alkylcarbamoyl, C 1-6 N,N-dialkylcarbamoyl, nitro and cyano; R 6 is selected from the group consisting of CH 2 OH, CH 2 CH 2 OH, CH 2 OC(═O)XR 9 , CH 2 CH 2 OC(═O)XR 9 , CH 2 OCOCH(R 13 )NHR 14 , CH 2 CO 2 R 10 , CH 2 NR 11 R 12 , CH 2 OP(═O)(OH) 2 and CH(NR 11 R 12 )CO 2 R 10 ; R 7 and R 8 taken independently are selected from the group consisting of hydrogen, amino, C 1-6 alkylamino, C 1-6 dialkylamino, amino-C 1-3 alkyl, C 1-3 alkylamino-C 1-3 alkyl, C 1-3 dialkylamino-C 1-3 alkyl and C 1-6 alkyl optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, alkoxy, thiol, alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, halogen and N-morpholinyl; R 9 is C 1-10 alkyl, C 1-10 heteroalkyl, (CH 2 ) o CO 2 H, CH═CHCO 2 H, aryl, (CH 2 ) n NR 11a R 12a or heteroaryl said aryl and said heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkyl sulfonyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, hydroxy, halogen, amino, C 1-6 alkylamino, C 1-6 dialkylamino, acylamino, acyl, C 1-6 alkoxycarbonyl, carbamoyl, C 1-6 N-alkylcarbamoyl, C 1-6 N,N-dialkylcarbamoyl, nitro and cyano; R 10 is hydrogen or C 1-10 alkyl; R 11 R 11a , R 12 and R 12a are (i) independently hydrogen or C 1-10 alkyl, or (ii) R 11 and R 12 taken together along with the nitrogen atom to which they are attached form a pyrrolidinyl, piperidinyl, azepinyl, or morpholine ring; R 13 taken alone is selected from the group consisting of the side chain of a naturally occurring amino acids, optionally substituted phenyl and C 1-5 unbranched or branched alkyl; R 14 taken alone is hydrogen, or C 1-6 alkyl; or, R 13 and R 14 taken together are (CH 2 ) 3 ; X is a bond, O, S, NH; n is 1 to 3; o is 1 to 6; or, acid or base addition salts thereof.