Patent ID: 8318941

Claim:
A compound of formula (I) enantiomers, diastereomers, salts, or tautomers thereof wherein: A is a phenyl, wherein said phenyl may be optionally substituted with one or more R 4 's; X is Cl, cyano, haloalkyl or —NO 2 ; W is O, S, SO, NH or SO 2 ; Y is a bond or an alkylene; R 1 is heteroaryl, aryl, or cycloalkyl, all of which may be optionally substituted with one or more R 4a 's; R 4 , at each occurrence, is independently selected from alkyl, aryl, halo, ═O, —CN, —NO 2 , —C(═O)OH, —C(═O)OR 10 , —OR 10 , —OH, —SH, —SR 10 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —C(═O)R 10 , —OC(═O)R 10 , —S(═O)R 10 , or —S(O) 2 R 10 , wherein the alkyl or aryl may be optionally substituted with one or more R 5 's; R 4a , at each occurrence, is independently selected from alkyl, aryl, halo, ═O, —CN, —NO 2 , —C(═O)OH, —C(═O)OR 10 , —OR 10 , —OH, —SR 10 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —C(═O)R 10 , —OC(═O)R 10 , —S(═O)R 10 , or —S(O) 2 R 10 , wherein the alkyl or aryl may be optionally substituted with one or more R 5 's; R 5 , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, halo, —CN, —C(═O)OH, —C(═O)OR 10 , —OR 10 , —SR 10 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —C(═O)R 10 , —OC(═O)R 10 , —S(═O)R 10 , or —S(O) 2 R 10 ; R 9 , at each occurrence, is independently hydrogen, alkyl, aryl, heteroaryl, wherein the heteroaryl contains 1-4 heteroatoms selected from N, O, and S; R 10 , at each occurrence, is independently selected from alkyl or aryl, wherein the alkyl or aryl may be optionally substituted with 0-3 R 10a ; R 10a , at each occurrence, is independently selected from alkyl, aryl, heteroaryl, halo, —C(═O)OH, —C(═O)OR 14 , —OR 14 , —SR 14 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —C(═O)NR 14 S(O) 2 R 9 , —S(O) 2 NR 14 C(═O)OR 9 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 CF 3 , —C(═O)R 14 , —NR 14 C(═O)H, —NR 14 C(═O)R 14 , —OC(═O)R 14 , or —S(O) 2 R 14 ; and R 14 , at each occurrence, is independently selected from hydrogen, alkyl, or aryl.