Patent ID: 8778972

Claim:
A compound of Formula I: a pharmaceutically acceptable salt thereof, wherein: X is CH 2 ; each R 1 are independently C 1-7 alkyl or C 3-8 cycloalkyl; each of R 2 and R 6 are independently hydrogen, halogen, cyano, hydroxy-C 1-7 alkyl, —OR 7 , C 3-8 cycloalkyl, halo-C 1-7 alkyl or —CH 2 —NR 8 —SO 2 —R 10 ; R 3 and R 4 are independently hydrogen, halogen or cyano; R 5 is C 1-7 alkyl, cyano, hydroxy, hydroxy-C 1-7 alkyl, hydroxy-C 3-8 cycloalkylalkyl, C 1-7 alkoxy-C 3-8 alkyl, C 6-10 aryl, C 3-8 cycloalkyl, halo-C 1-7 alkyl, —NR 8 R 9 , —CH 2 —NR 8 —C(O)NR 8 R 9 , —CH 2 —NR 8 —SO 2 —R 10 , —C(O)—R 10 , —SO 2 R 10 , —C(O)—NR 8 R 9 , —SO 2 —NR 8 R 9 , —NR 8 C(O)—R 10 , —CH 2 CN, or —NR 8 —SO 2 —R 10 ; R 7 is C 1-7 alkyl, C 3-8 cycloalkyl-C 1-7 alkyl, C 6-10 aryl-C 1-7 alkyl, or —C(O)—R 10 ; in which C 6-10 aryl, C 1-7 alkyl and C 3-8 cycloalkyl are optionally substituted with C 1-7 alkoxy, halo, halo-C 3-8 alkoxy, C 1-7 alkyl, OH or halo-C 1-7 alkyl; each of R 8 , R 9 are independently hydrogen, C 1-7 alkyl, halo-C 1-7 alkyl, or C 6-10 aryl-C 1-7 alkyl; R 10 is hydrogen, C 1-7 alkyl, halo-C 1-7 alkyl, C 6-10 aryl-C 1-7 alkyl, or —NR 8 R 9 ; or a pharmaceutically acceptable salt thereof.