Patent ID: 8222247

Claim:
A compound according to formula (I), or an enantiomer, diastereomer, tautomer, or a pharmaceutically-acceptable salt, thereof, wherein: A is thienyl substituted with one to four groups, R 1 , R 2 , R 3 , and/or R 4 ; M is aryl; M a is a linker between C and M and is a bond; Q is hydrogen; Z a —Z is R m is selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, nitro, cyano, OR 23 , NR 23 R 24 , C(═O)R 23 , CO 2 R 23 , C(═O)NR 23 R 24 , —O—C(═O)R 23 , NR 23 C(═O)R 24 , NR 23 C(═O)OR 24 , NR 23 C(═S)OR 24 , S(═O) p R 25 , NR 23 SO 2 R 25 , SO 2 NR 23 R 24 , cycloalkyl, heterocyclo, aryl, and heteroaryl; R 23 and R 24 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, C(═O)alkyl, CO 2 (alkyl), SO 2 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, aryl, heteroaryl, heterocyclo, and cycloalkyl; R 25 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, substituted amino, heteroaryl, heterocyclo, cycloalkyl, and aryl; R 1 , R 2 , R 3 , and R 4 at each occurrence are independently selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, nitro, cyano, —OR 10 , —SR 10 , —NR 10 R 11 , —C(═O)R 10 , —CO 2 R 10 , —C(═O)NR 10 R 11 , —O—C(═O)R 10 , —NR 10 C(═O)R 11 , —NR 10 C(═O)OR 11 , —NR 10 C(S)OR 11 , —S(═O) p R 12 , —NR 10 SO 2 R 12 , —SO p NR 10 R 11 , cycloalkyl, heterocyclo, aryl, and heteroaryl; R 6 is selected from alkyl or substituted alkyl; R 7 is selected from hydrogen alkyl, or substituted alkyl; R 10 and R 11 at each occurrence are independently selected from the group consisting of: hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, —SO p alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; R 12 is independently selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; R 22 is hydrogen; and p is 1 or 2.