Patent ID: 8252306

Claim:
A process for the preparation of a pharmaceutical composition comprising: (A) a semi-solid delivery vehicle, comprising: (i) a polyorthoester consisting of formula I where: R* is ethyl; n is an integer of 5 to 1000; and A is R 1 or R 3 where R 1 is: where: p is an integer of 1 to 20; R 5 is hydrogen; and R 6 is: where: s is an integer of 0 to 10; R 3 is: where: x is an integer of 0 to 30; in which about 0.05-30 mol percent of the A units are of the formula R 1 ; and (ii) polyethylene glycol monomethyl ether; and (B) granisetron in an amount of 1-5 weight % of the composition; the process comprising mixing the components (A)(i) and (A)(ii) and (B) to form the composition.