Patent ID: 8242271

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: T is —NHC(O)— or —C(O)NH—; W is CH or N; each of R a , R b , R c , and R d is independently selected from R, OR, or halogen; each R is independently hydrogen, lower alkyl, or lower haloalkyl; R 1 is -L-Y, wherein: L is a bivalent C 2-8 straight or branched, hydrocarbon chain wherein L has at least one double bond and at least one methylene unit of L is replaced by cyclopropylene, —NRC(O)—, —C(O)NR—, —S—, —S(O)—, —SO 2 —, —C(═S)—, —C(═NR)—, —N═N—, or —C(═N 2 )—; and one or two additional methylene units of L are optionally and independently replaced by —O—, —N(R)—, or —C(O)—; or L is a bivalent C 2-8 straight or branched, hydrocarbon chain wherein L has at least one triple bond and one or two additional methylene units of L are optionally and independently replaced by —NRC(O)—, —C(O)NR—, —S—, —S(O)—, —SO 2 —, —C(═S)—, —C(═NR)—, —O—, —N(R)—, or —C(O)—; or L is a bivalent C 2-8 straight or branched, hydrocarbon chain wherein one methylene unit of L is replaced by cyclopropylene and one or two additional methylene units of L are independently replaced by —C(O)—, —NRC(O)—, —C(O)NR—, —N(R)SO 2 —, or —SO 2 N(R)—; or L is a bivalent C 1-8 , straight or branched, alkylene chain, wherein at least one methylene unit of L is replaced by —C(═N 2 )—, and one or two additional methylene units of L are optionally and independently replaced by —NRC(O)—, —C(O)NR—, —S—, —S(O)—, —SO 2 —, —C(═S)—, —C(═NR)—, —O—, —N(R)—, or —C(O)—; and Y is hydrogen, C 1-6 aliphatic optionally substituted with oxo, halogen, or CN, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with 1-4 groups independently selected from -Q-Z, oxo, halogen, CN, or C 1-6 aliphatic, wherein: Q is a covalent bond or a bivalent C 1-6 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of Q are optionally and independently replaced by —NR—, —NRC(O)—, —C(O)NR—, —S—, —O—, —C(O)—, —SO—, or —SO 2 —; and Z is hydrogen or C 1-6 aliphatic optionally substituted with oxo, halogen, or CN; R 2 is selected from R, halogen, —N(R)C(O)OR, or 1-imidazoyl substituted with R, or: R 1 and R 2 are taken together with their intervening atoms to form a 5-7 membered saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted -L-Y and 0-3 groups independently selected from oxo, halogen, CN, or C 1-6 aliphatic; and R 3 is selected from hydrogen, lower alkyl, or halogen.