Patent ID: 7435791

Claim:
A process for solution synthesis of a peptide in an organic solvent or a mixture of organic solvents, the process comprising repetitive cycles of steps (a)-(c): wherein step (a) comprises a coupling step, using an excess of a molecule comprising an activated carboxylic component comprising at least one temporary protecting group to acylate an amino component, wherein step (b) comprises a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the at least one temporary protecting group on the growing peptide; wherein step (c) comprises one or more aqueous extractions, and wherein the process comprises at least one step (b), referred to as step (b′), in which an amine comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions, and wherein the anion is selected from the group consisting of carboxylate, sulfonate, sulfate, phosphonate, phosphate and phenolate.