Patent ID: 7557123

Claim:
A novel heterocyclic compound of the formula (I): wherein R 1 is a hydrogen atom or C 1-6 alkyl; R 2 is a hydrogen atom, —CO—R 3 wherein R 3 is C 2-6 alkyl optionally substituted by halogen, —CO—C(R 4 )═C(R 4 )—R 5 wherein R 4 is optionally the same as the other R 4 and is a hydrogen atom or C 1-4 alkyl and R 5 is C 1-8 alkyl, C 2-8 alkenyl, aryl or an aromatic heterocycle, —CO—C≡C—R 6 wherein R 6 is C 1-8 alkyl, wherein m is an integer of 2 to 7, aryl, optionally substituted aryl C 1-3 alkyl, C 1-6 alkyl optionally substituted by halogen, C 2-6 alkenyl, C 3-8 cycloalkyl or C 3-8 cycloalkyl C 1-3 alkyl; Y is wherein R 7 is a hydrogen atom or C 1-4 alkyl, R 8 is C 5-8 alkyl, C 4-8 cycloalkyl, C 1-4 alkylthio C 1-6 alkyl, R 10 —C(R 9 )═C(R 9 )— wherein R 9 is optionally the same as the other R 9 and is a hydrogen atom or C 1-4 alkyl and R 10 is C 1-6 alkyl optionally substituted by halogen, C 2-8 alkenyl, aryl, an aromatic heterocycle, C 3-8 cycloalkyl, C 3-8 cycloalkyl C 1-3 alkyl, C 1-4 alkoxy C 1-6 alkyl, C 1-4 alkylthio C 1-6 alkyl or C 1-6 alkyl substituted by (R 9 ) 2 N— wherein R 9 is optionally the same as the other R 9 and is a hydrogen atom or C 1-4 alkyl, R 12 —CO—N(R 11 )— wherein R 11 is a hydrogen atom or C 1-4 alkyl and R 12 is C 1-6 alkyl or aryl, R 13 -Z- wherein R 13 is C 1-8 alkyl or aryl and Z is an oxygen atom or a sulfur atom, or wherein k is an integer of 2 to 7 and X is an oxygen atom or a sulfur atom, or R 15 —C(R 14 )═N—O— wherein R 14 is a hydrogen atom or C 1-4 alkyl and R 15 is aryl or an aromatic heterocycle; Y—(CH 2 ) n —O— is bonded to the 6- or 7-position of a tetrahydroisoquinoline skeleton; and n is an integer of 1 to 4 or a pharmaceutically acceptable salt thereof.