Patent ID: 8293789

Claim:
Method of solubilizing latanoprost for preparing a chemically stable ophthalmic aqueous solution for the treatment of distinct ocular ailments, the method comprising: a) placing 5.000 g of latanoprost in a container; b) adding to the container, approximately 15 L of a solution containing 7.5% of hydroxypropylbetacyclodextrins, 0.7% of monobasic phosphate of monohydrated sodium, 0.6% of dibasic phosphate of anhydrous sodium and 0.2% of sodium hyaluronate, and agitate at 500 to 550 rpm in order to dissolve the latanoprost; c) waiting until it is fully dissolved and add to the solution, 0.005% to 0.02% of benzalkonium chloride, and always rinsing with the same solution with which the latanoprost was dissolved; and d) agitating until the solution is homogenized.