Patent ID: 7745451

Claim:
A compound having a formula 1: wherein A and B are independently CR 2′ R 2′ , CO, or CS; Y is CR 2′ R 2′ ; W is N; Z is O or NR 2 ; L is substituted or unsubstituted C 1 -C 9 alkylene or substituted or unsubstituted C 1 -C 9 heteroalkylene; R 1 is a substituted or unsubstituted carbocyclic group or a substituted or unsubstituted heterocyclic group; R 2 is hydrogen, C 1 -C 6 alkyl, or C 3 -C 8 cycloalkyl; each R 2′ is independently hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, aryl, or aralkyl; R 3 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; and R 4′ is R 4 or —Z-L′-R 4 , wherein Z′ is a single bond, NR 2′ , O, S, SO, SO 2 , COO, or CONR 2′ , and L′ is (C 1 -C 6 )alkylene; and wherein R 4 is selected from the group consisting of H, alkyl, —C(O)R 20 , —NR 21 C(O)R 22 , alkylamino, alkylthio, alkoxy, alkoxycarbonyl, alkylarylamino, arylalkyloxy, amino, aryl, arylalkyl, —SO 2 R 23 , substituted sulfanyl, aminosulfonyl, arylsulfonyl, dihydroxyphosphoryl, azido, carbamoyl, carboxyl, cyano, cycloalkyl, cycloheteroalkyl, dialkylamino, halo, heteroaryloxy, heteroaryl, heteroalkyl, hydroxy, nitro, and —SH; wherein R 20 is hydrogen, alkyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroalkyl, heteroaryl, or heteroarylalkyl; R 21 is hydrogen, alkyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroalkyl, heteroaryl, or heteroarylalkyl; R 22 is alkyl, alkoxy, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroalkyl, heteroaryl, or heteroarylalkyl; and R 23 is alkyl, aryl, or heteroaryl; or a pharmaceutically acceptable salt, a stereoisomer, a tautomer or an isotopic variant thereof.