Patent ID: 8435529

Claim:
A method of treating cancer comprising: a) administering to a subject with cancer an anti-Trop-2 antibody or antigen-binding fragment thereof conjugated to a first therapeutic agent; and b) administering to said subject an anti-pancreatic cancer mucin antibody or antigen-binding fragment thereof conjugated to a second therapeutic agent; wherein the anti-Trop-2 antibody or fragment thereof binds to the same epitope as an anti-Trop-2 antibody comprising the light chain CDR sequences CDR1 (KASQDVSIAVA, SEQ ID NO:7); CDR2 (SASYRYT, SEQ ID NO:8); and CDR3 (QQHYITPLT, SEQ ID NO:9) and the heavy chain CDR sequences CDR1 (NYGMN, SEQ ID NO:10); CDR2 (WINTYTGEPTYTDDFKG, SEQ ID NO:11) and CDR3 (GGFGSSYWYFDV, SEQ ID NO:12) and wherein the anti-pancreatic cancer mucin antibody or fragment thereof binds to the same epitope as an anti-pancreatic cancer mucin antibody comprising the light complementarity determining region (CDR) sequences CDR1 (SASSSVSSSYLY, SEQ ID NO:1); CDR2 (STSNLAS, SEQ ID NO:2); and CDR3 (HQWNRYPYT, SEQ ID NO:3); and the heavy chain CDR sequences CDR1 (SYVLH, SEQ ID NO:4); CDR2 (YINPYNDGTQYNEKFKG, SEQ ID NO:5) and CDR3 (GFGGSYGFAY, SEQ ID NO:6).