Patent ID: 7759499

Claim:
A compound, or enantiomers, stereoisomers, rotamers, tautomers, diastereomers and racemates of said compound, or a pharmaceutically acceptable salt, or ester of said compound, said compound of the general structure shown in Formula I: wherein: R 1 is NR 9 R 10 , wherein R 9 and R 10 are the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, aryl-, cycloalkyl- and arylalkyl; A and M are the same or different, each being independently selected from R, NR 9 R 10 , SR, SO 2 R, and halo; E is C(H) or C(R); L is C(H) or C(R); R, R 2 , and R 3 are the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, cycloalkyl-, heteroalkyl- aryl-, (cycloalkyl)alkyl- and aryl-alkyl-; Y is selected from the following moieties: wherein Y 30 is selected from where u is a number 0-6 G is NH; and R 17 , R 18 , R 19 , T 1 and T 3 are the same or different, each being independently selected from the group consisting of H, alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, cycloalkyl, aryl and arylalkyl; wherein each of said alkyl, aryl or cycloalkyl are unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of: hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, amido, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, sulfonamido, alkyl, aryl, heteroaryl, alkylsulfonamido, arylsulfonamido, keto, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halo, cyano, and nitro.