Patent ID: 7589200

Claim:
A compound according to structural Formula (II): and salts, hydrates, solvates, N-oxides and prodrugs thereof wherein: R 4 is selected from the group consisting of phenyl mono-substituted at the 3-position with an R 8 groups, phenyl di-substituted at the 3,4- or 3,5-positions with the same or different R 8 groups and phenyl trisubstituted at the 2,3,4-, 2,3,5- or 3,4,5-positions with the same or different R 8 groups; R 8 is selected from the group consisting of R e , R b , or R e substituted with one or more of the same or different R a or R b , —OR a substituted with one or more of the same or different R a or R b , —B(OR a ) 2 , —B(NR c R c ) 2 , —(CH 2 ) m —R b , —(CHR a ) m —R b , —O—(CH 2 ) m —R b , —O—CHR a R b , —O—CR a (R b ) 2 , —O—(CHR a ) m —R b , —O—(CH 2 ) m —CH[(CH 2 ) m R b ]R b , —O—(CH 2 ) m —C(O)NH—(CH 2 ) m —R b , —O—(CHR a ) m —C(O)NH—(CHR a ) m —R b , —NH—(CH 2 ) m —R b , —NH—(CHR a ) m —R b , —NH[(CH 2 ) m R b ] and —N[(CH 2 ) m R b ] 2 ; each R a is independently selected from the group consisting of hydrogen, (C1–C6) alkyl, (C3–C8) cycloalkyl, cyclohexyl, (C4–C11) cycloalkylalkyl, (C5–C10) aryl, phenyl, (C6–C16) arylalkyl, benzyl, 2–6 membered heteroalkyl, 3–9 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4–11 membered cycloheteroalkylalkyl, 5–10 membered heteroaryl and 6–16 membered heteroarylalkyl; each R b is a suitable group independently selected from the group consisting of ═O, —OR d , (C1–C3) haloalkyloxy, —OCF 3 , —SR d , —NR c R c , halogen, —CF 3 , —CN, —NO 2 , —S(O)R d , —S(O) 2 R d , —S(O) 2 OR d , —S(O)NR c R c , —S(O) 2 NR c R c , —C(O)R d , —C(O)OR d , —C(O)NR c R c , —OC(O)R d , —OC(O)OR d and —OC(O)NR c R c ; each R c is independently a protecting group or R a , or, alternatively, two R c are taken together with the nitrogen atom to which they are bonded to form a 5 to 8-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the same or different additional heteroatoms and which may optionally be substituted with one or more of the same or different R a or suitable R b groups; each R d is independently a protecting group or R a ; each R e is independently selected from the group consisting (C1–C6) alkyl, (C3–C8) cycloalkyl, cyclohexyl, (C4–C11) cycloalkylalkyl, (C5–C10) aryl, phenyl, (C6–C16) arylalkyl, benzyl, 2–6 membered heteroalkyl, 3–9 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4–11 membered cycloheteroalkylalkyl, 5–10 membered heteroaryl and 6–16 membered heteroarylalkyl; each m is independently an integer from 1 to 3; and LG is a leaving group.