Patent ID: 7338957

Claim:
A compound of formula I: in which: W is N; Y is selected from C, S and S(O); Z is a divalent radical selected from —Y(O)NR 5 — and —NR 5 Y(O)—; wherein Y is selected from C, S and S(O); and R 5 is selected from hydrogen and C 1-12 alkyl; R 1 is selected from hydrogen, halo, hydroxy C 1-6 alkyl, C 1-6 alkoxy and —NR 6 R 7 ; wherein R 6 is selected from hydrogen and C 1-6 alkyl; R 7 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; or R 6 and R 7 together with the nitrogen to which both R 6 and R 7 are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 7 or of the combination of R 6 and R 7 can be optionally substituted with 1 to 3 radicals selected from halo, cyano, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, —XNR 8 R 8 , —XC(O)NR 8 R 8 , —XC(O)NR 8 XOR 8 , —XS(O) 0-2 NR 8 R 8 , —XS(O) 0-2 R 8 , —XNR 8 S(O) 0-2 R 8 , —XNR 8 C(O)R 8 , —XNR 8 SR 8 , —XP(O)NR 8 R 8 , —XCR 8 (OR 8 )R 8 , —XOC(O)R 8 , —XOR 8 and —XOR 9 ; wherein X is a bond or C 1-12 alkylene, R 8 is independently selected from hydrogen and C 1-6 alkyl, R 9 is selected from C 6-10 aryl and C 5-10 heteroaryl; R 2 is selected from hydrogen and C 1-6 alkyl; R 3 is selected from hydrogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, mercapto, halo, nitro and cyano; n is 0, 1 or 2; R 4 is selected from hydrogen, halo, hydroxy, cyano, nitro, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 1-12 alkoxy, halo-substituted-C 1-12 alkoxy and —XR 10 ; wherein X is a bond or C 1-6 alkylene, R 10 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 10 is optionally substituted with a radical selected from halo, hydroxy, cyano, nitro, C 1-6 -alkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy and halo-substituted-C 1-6 alkoxy; m is 1, 2 or 3; and wherein the phenyl rings A and B can independently have up to four —C═ groups replaced by —N═; or the pharmaceutically acceptable salts thereof.