Patent ID: 8183380

Claim:
A compound of formula (I) wherein A is —CH 2 — or —O—; R 1 is hydrogen or alkyl; R 2 is hydrogen, heterocycloalkyl, —(CH 2 ) a —R a , wherein R a is hydrogen, alkoxy, hydroxy, cyano, or NR i R ii , wherein R i and R ii are each independently hydrogen, alkyl or C(O)O-alkyl, allyl, —C(NH)—S—R b , wherein R b is alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, cyanoalkyl, or alkenyl, —C(NR c )NR d R e , wherein R c , R d , and R e are each independently hydrogen, alkyl, cycloalkyl, heterocycloalkyl, or wherein R d and R e together with the nitrogen to which they are bound form a heterocycloalkyl, —C(O)R f , wherein R f is alkyl, —(CH 2 ) b -cycloalkyl, —(CH 2 ) b —Oalkyl, —(CH 2 ) b -heterocycloalkyl, —O-heterocycloalkyl, or —(CH 2 ) b —NR iii R iv , wherein R iii and R iv are each independently hydrogen, alkyl, —C(O)Oalkyl, —(CH 2 ) b -cycloalkyl, —(CH 2 ) a —Oalkyl, bicyclic cycloalkyl, bicyclic cycloalkenyl, —(CH 2 ) b -heterocycloalkyl, —(CH 2 ) a —O-heterocycloalkyl, or —(CH 2 ) a —NR′R″, wherein R′ and R″ are each independently hydrogen, alkyl or cycloalkyl, —C(S)NR v R vi , wherein R v and R vi are each independently H, alkyl or cycloalkyl, —S(O) 2 NR vii R viii , wherein R vii and R viii are each independently H, alkyl, —C(O)Oalkyl, alkylene-O alkyl, cycloalkyl, or heterocycloalkyl, or —S(O) 2 -heterocycloalkyl, or R 1 and R 2 together with the N atom to which they are bound form a 5- or 6-membered heterocycloalkyl; R 3 , R 4 , R 5 and R 6 are each independently selected from the group consisting of H, halo, alkyl, haloalkyl, hydroxyalkyl, cyanoalkyl, alkoxy, haloalkoxy, —O-alkylene-O-alkyl, hydroxyl, oxo, cyano, nitro and NR ix R x , wherein R ix and R x are each independently H or alkyl; a is 1 to 6; b is 0 to 6; and n is 1 or 2, and wherein heterocycloalkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxy, hydroxyalkyl, benzyl, oxo, —C(O)Oalkyl, cycloalkyl, alkylene-O-alkyl, —C(O)haloalkyl, cyanoalkyl, alkylene-S(O) 2 -alkyl, -alkylene-C(O)N(alkyl) 2 , halo, haloalkyl and alkyoxy; and wherein cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxy, hydroxyalkyl, phenyl, oxo, cyanoalkyl, -alkylene-C(O)N(alkyl) 2 , hydroxyalkyl, haloalkyl, halo, and alkyoxy; or a pharmaceutically acceptable salt thereof.