Patent ID: 7989608

Claim:
A method of treating a mammalian subject infected with a pathogen which acts to up-regulate IL-10 during infection in a mammalian host, as evidenced by increased serum levels of IL-10, comprising administering to the subject, a therapeutically effective amount of an antisense composition containing an antisense oligonucleotide compound (i) composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, (ii) capable of uptake by monocytes, lymphocytes, and dendritic cells in a mammalian subject, (iii) containing between 10-40 nucleotide bases, and (iv) having a targeting sequence complementary to at least 12 contiguous bases of the 5′-most 25 bases of exon 2 or exon 4 of the preprocessed human IL-10 transcript contained within SEQ ID NO:6, and identified by SEQ ID NOS:2 and 5, respectively.