Patent ID: 7928060

Claim:
An Amylin Family Polypeptide-6 (AFP-6) agonist analog having the amino acid sequence: X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -QVQNLSHRLWQL-X 21 -X 22 -X 23 -X 24 -X 25 -X 26 -X 27 -X 28 -SAPV-X 33 -PSSPHSY (SEQ ID NO: 41) wherein X 1 is absent, TQAQLLRVG (SEQ ID NO: 42), any of one or more consecutive amino acids of SEQ ID NO:42, N-aryl, or N-acyl with a substituent selected from a C1-C18 alkyl, a substituted alkyl or a heteroaryl moiety; X 2 is M, S, C, substituted L, K, D or E, where the side chain can be linked via an amide bond, or any amino acid that can form a bond with X 8 ; X 3 is V, D, L, G, N, A, or S; X 4 is V, D, L, G, N, A, S or T; X 5 is V, D, L, G, N, A, or S; X 6 is V, D, L, G, N, A, S, or absent; X 7 is T, S, homoserine, (S)-2-Amino-3-hydroxy-3-methylbutanoic acid (Ab) or (2R,3R)-2-Amino-3-hydroxy-4-methylpentanoic acid (Ap); X 8 is M, S, C, substituted L, K, D or E, or any amino acid that can form a bond with X 2 ; X 21 is M, G, P, A, or absent; X 22 is M, G, P, A, or absent; X 23 is M, G, P, A, or absent; X 24 is M, G, P, A, or absent; X 25 is M, G, P, A, or absent; X 26 is R or absent, wherein when X 26 is absent, X 27 is absent; X 27 is Q or absent, wherein when X 27 is absent, X 26 is absent; X 28 is D or E; X 33 is D or E; wherein the amino acid sequence is not SEQ ID NO: 1 or SEQ ID NO: 2.