Patent ID: 8617573

Claim:
A method for reducing botulinum toxin serotype B (BoNT/B) toxicity in a human or non-human animal subject comprising administering to the subject an agent that reduces binding between BoNT/B and a polypeptide that is at least 95% identical to the amino acid sequences selected from the group consisting of amino acids 32-52 of SEQ ID NO:2 (mouse synaptotagmin I botulinum toxin serotype B (BoNT/B)-binding domain), amino acids 33-53 of SEQ ID NO:5 (human synaptotagmin I botulinum toxin serotype B (BoNT/B)-binding domain), amino acids 40-60 of SEQ ID NO:7 (mouse synaptotagmin II botulinum toxin serotype B (BoNT/B)-binding domain), amino acids 40-60 of SEQ ID NO:9 (rat synaptotagmin II botulinum toxin serotype B (BoNT/B)-binding domain), and amino acids 37-57 of SEQ ID NO:10 (human synaptotagmin II botulinum toxin serotype B (BoNT/B)-binding domain).