Patent ID: 7410949

Claim:
A neuropeptide-2 receptor agonist of the formula (I): Y—R 1 —R 2 —X—R 3 —R 4 —R 5 —R 6 —R 7 —R 8 —R 9 —R 10 —R 11 —R 12 —R 13 —R 14 —NH 2 (I) wherein: X is selected from the group consisting of N-piperazin-1-yl-4(3H)-quinozolinone-3-acetic acid (Pqa), N-(5-O-carboxymethyl )-serotonin (Cms), 4-(2-aminoethyl)-6-dibenzofuranpropanoic acid, 4-(1-piperidin-4-yl)-butanoic acid and 4-(2-aminoethyl) -1-carboxymethyl piperazine, Y is H, a substituted or unsubstituted alkyl, a substituted or unsubstituted lower alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted alkoxy or a poly(ethylene) glycol moiety, R 1 is Ile, Ala, (D) Ile, N-methyl Ile, Aib, 1-1 Aic, 2-2 Aic, Ach or Acp, R 2 is Lys, Ala, (D) Lys, NMelys, Nle or (Lys-Gly), R 3 is Arg, Ala, (D)Arg, N-methylArg, Phe, 3,4,5- TrifluoroPhe or 2,3,4,5,6-pentafluoro Phe, R 4 is His, Ala, (D)His, N-methyl His, 4-MeOApc, 3-Pal or 4-Pal, R 5 is Tyr, Ala, (D) Tyr, N- methyl Tyr, Trp, Tic, Bip, Dip, (1)Nal, (2)Nal, 3,4,5-TrifluroPhe or 2,3,4,5,6- Pentafluoro Phe, R 6 is Leu, Ala, (D)Leu or N-methyl Leu, R 7 is Asn, Ala or (D)Asn, R 8 is Leu, Ala, (D)Leu or N-methyl Leu, R 9 is Val, Ala, (D) Val or N-methyl Val, R 10 is Thr, Ala or N-methyl Thr, R 11 is Arg, (D) Arg or N-methyl Arg, R 12 is Gln or Ala, R 13 is Arg, (D)Arg or N-methyl Arg, and R 14 is Tyr, (D) Tyr or N- methyl Tyr, or a pharmaceutically acceptable salt thereof.