Patent ID: 7595314

Claim:
A compound of formula wherein Ar is unsubstituted or substituted 6-membered heteroaryl containing one, two or three nitrogen atoms, and wherein the substituted heteroaryl groups are substituted by one or more substituents selected from the group consisting of hydroxy, halogen, NO 2 , CN, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl substituted by halogen, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy substituted by halogen, NR 7 R 8 , C(O)R 9 and SO 2 R 10 ; R 1 is hydrogen or (C 1 -C 6 )-alkyl; R 2 and R 2′ are each independently hydrogen, (CR 2 ) n -hydroxy wherein R is hydrogen or C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 1 -C 6 )-alkyl substituted by halogen, (CH 2 ) n —(C 3 -C 6 )-cycloalkyl, (CH 2 ) n -heterocycloalkyl, (CH 2 ) n —O—(C 1 -C 6 )-alkyl or (CH 2 ) n -aryl or R 2 and R 2′ form together with the N atom to which they are attached a heterocycloalkyl ring, optionally containing in addition to the N atom a further heteroatom selected from the group consisting of N, S and O, which rings are unsubstituted or substituted by (CH 2 ) n -hydroxy, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy, (CH 2 ) n —O—(C 1 -C 6 )-alkyl, or R 2 and R 2′ form together with the N atom to which they are attached a 5-membered heteroaryl group, optionally containing in addition to the N atom one, two or three further nitrogen atoms and wherein the heteroaryl group is optionally substituted by (C 1 -C 6 )-alkyl; R 3 , R 4 and R 6 are each independently hydrogen, halogen, (C 1 -C 6 )-alkyl or (C 1 -C 6 )-alkoxy; R 5 is NO 2 , CN, C(O)R 9 , S—(C 1 -C 6 )-alkyl, SO 2 R 10 or NR 11 R 12 ; R 7 and R 8 are each independently hydrogen, (CH 2 ) n —(C 3 -C 6 )-cycloalkyl or (C 1 -C 6 )-alkyl, or form together with the N atom to which they are attached a heterocycloalkyl ring, optionally containing in addition to the N atom a further heteroatom, selected from the group consisting of N, S and O; R 9 is hydroxy, (C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, (C 1 -C 6 )-alkoxy or NR 7 R 8 ; R 10 is (C 1 -C 6 )-alkyl, (CH 2 ) n —(C 3 -C 6 )-cycloalkyl or NR 7 R 8 ; R 11 and R 12 are each independently hydrogen, C(O)—(C 1 -C 6 )-alkyl, SO 2 —(C 1 -C 6 )-alkyl, or form together with the N-atom to which they are attached a 5-membered heteroaryl group optionally containing in addition to the N atom one, two or three nitrogen atoms and wherein the heteroaryl group is optionally substituted by halogen, (C 1 -C 6 )-alkyl or (CH 2 ) n (C 3 -C 6 )-cycloalkyl; n is 0, 1 or 2; wherein the 5-membered heteroaryl group is selected from the group consisting of pyrrolyl 2,5-dihydro-pyrrol-1-yl, imidazolyl, pyrazolyl, triazolyl, and tetrazolyl; or a pharmaceutically acceptable acid addition salt thereof.