Patent ID: 7541358

Claim:
A compound of formula I wherein W is SO 2 , CO, CONH, CSNH or CH 2 ; X is CR 7 or N; Y is CR 8 ; Z is O, SO p or NR 9 ; R 1 and R 2 are each independently H or C 1 -C 6 alkyl; n is an integer of 2, 3 or 4; R 3 and R 4 are taken together with the atom to which they are attached to form an optionally substituted 3- to 6-membered ring optionally containing an additional heteroatom selected from O, N or S; R 5 is H, halogen, CN, OR 13 , CO 2 R 14 , CONR 15 R 16 , CNR 17 NR 18 R 19 , SO 2 NR 20 R 21 , SO q R 22 or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, phenyl or heteroaryl group each optionally substituted; m is an integer of 1, 2 or 3; p and q are each independently 0 or an integer of 1 or 2; R 6 is an optionally substituted heteroaryl group or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S; R 7 and R 8 are each independently H, halogen or a C 1 -C 6 alkyl, aryl, heteroaryl or C 1 - C 6 alkoxy group each optionally substituted; R 9 is H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 15 , R 16 , R 17 , R 18 and R 19 are each independently H or C 1 -C 4 alkyl; R 13 is H, COR 23 or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl or heteroaryl group each optionally substituted; R 14 is H or a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted; R 20 and R 21 are each independently H or a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted; and R 22 and R 23 are each independently an optionally substituted C 1 -C 6 alkyl, aryl or heteroaryl group; or a pharmaceutically acceptable salt thereof.