Patent ID: 8716322

Claim:
A method for the treatment of a heme-related malignancy in a patient, comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition comprising a compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof: wherein L is selected from C═O and C═S; X is selected from O, S, NH, and N—C 1-6 alkyl; Z is absent, C 1-6 alkyl, or C 1-6 alkoxy; R 1 , R 2 , and R 3 are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 alkoxyalkyl, aryl, C 1-6 aralkyl, heteroaryl, heterocyclyl, C 1-6 heterocycloalkyl, C 1-6 heteroaralkyl, carbocyclyl, and C 1-6 carbocyclolalkyl; R 4 is selected from hydrogen, C 1-6 aralkyl, and C 1-6 alkyl; R 5 is selected from the group consisting of isoxazole, isothiazole, furan, thiophene, oxazole, thiazole, pyrazole, and imidazole; and R 6 and R 7 are independently selected from hydrogen, C 1-6 alkyl, and C 1-6 aralkyl and a pharmaceutically acceptable diluent or carrier.