Patent ID: 8420626

Claim:
A compound of formula (I), wherein: O represents a macro ring which is (1,4,8,11-tetraazacyclotetradecan-1-yl); (1,4,7,10-tetraazacyclododecan-1-yl); [3,7,11-triaza-dicyclo[11.3.1]heptadecan-1(16),13(17),14-trien-7-yl]; or [3,7,11,17-tetraaza-dicyclo[11.3.1]heptadecan-1(16),13(17),14-trien-7-yl]; R 1 represents a radical selected from the group consisting of: hydrogen, halogen; perfluoroalkyl; alkoxyalkyl; amino; alkylamino; dialkylamino; amido; alkylaminoalkyl; unsubstituted or substituted, saturated or unsaturated straight or branched alkyl; carboxyl; substituted or unsubstituted phenyl, the substituents of the phenyl being at least one radical selected from the group consisting of: hydroxyl, alkoxy, alkoxyalkyl, halogen, perfluoroalkyl, thio, nitro, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, carboxyamido, carboxyamidoalkyl, alkyl, cycloalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, aminosulfonyl, amidino, cyano, amino, amido, alkylamino, dialkylamino, alkylaminoalkyl, or alkoxy mono-substituted by substituent selected from the group consisting of carboxyl, amino, alkylamino or dialkylamino; cycloalkyl; or heterocyclic radical selected from the group consisting of: pyridyl, thienyl, pyrazolyl, tetrazolyl, furyl, pyrrolyl, imidazolyl, triazolyl and thiazolyl; R 2 represents a radical selected from the group consisting of: hydrogen, hydroxyl, mercapto, alkoxy, carboxyl, carboxyalkyl, amino, alkylamino, dialkylamino, carboxyamido, carboxyamidoalkyl, aminosulfonyl or acetamido; and X represents a divalent linking radical selected from the group consisting of: —N═CH—, —CH═N—, —(CH 2 ) n —NH—, —NH—(CH 2 )—, —(CH 2 ) n —, —CH═CH— or —N═N—, n is an integer from 1 to 8, or an optical isomer, a pharmaceutically acceptable salt, or a hydrate thereof.