Patent ID: 8071587

Claim:
A compound according to formula I: or a pharmaceutically acceptable salt thereof wherein the C5-C6 bond can either be saturated or unsaturated; R 1 is phenyl or (2-5C)heteroaryl, both optionally substituted with one or more substituents selected from R 13 or R 1 is (1-6C)alkyl, halogen, cyano, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (5-6C)cycloalkenyl, (2-5C)heterocycloalkyl or (2-5C)-heterocycloalkenyl; R 3 is (di)[(1-6C)alkyl]amino, optionally substituted with hydroxy or R 3 is a group selected from or R 3 is (1-6C)alkyl, (3-6C)cycloalkyl, (di)[(1-4C)alkyl]amino(1-4C)alkyl or R 3 is (2-6C)heterocycloalkyl; (2-6C)heterocycloalkyl(1-4C)alkyl, the (2-6C)heterocycloalkyl moiety of which optionally may be substituted with (1-4C)alkylcarbonyl or (3-6C)cycloalkylcarbonyl, R 3 is pyrrolidin-1-yl, azepin-1-yl, 1,4-oxazepin-1-yl, all optionally substituted with one or more (1-4C)alkyl substituents R 8 is H, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkoxy(1-4C)alkyl, hydroxy or (2-4C)alkenyl; R 9 is H, halogen, hydroxy, amino, (2-6C)alkynyl, (2-5C)heterocycloalkyl, (3-6C)cycloalkoxy, (2-5C)heterocycloalkoxy, (di)[(1-4C)alkyl]aminocarbonyl, (2-5C)heterocycloalkylcarbonyl, (2-5C)heteroarylaminocarbonyl, (2-5C)heterocycloalkylcarbonylamino, (2-5C)heteroarylcarbonylamino, formyl, cyano, nitro, (di)[(1-4C)alkyl]aminocarboxy, (1-6C)alkylcarbonyl, (1-4C)alkoxycarbonyl, (di)[(1-4C)alkyl]amino, (di)[(1-4C)alkyl]aminocarbonylamino, (1-4C)alkoxycarbonylamino, (di)[(1-4C)alkyl]aminosulfonylamino, (1-6C)alkylthio or (1-4C)alkylsulfonylamino or R 9 is (1-6C)alkyl, (1-6C)alkoxy or (2-6C)alkenyl, all optionally substituted with one or more substituents selected from halogen, hydroxy, amine, azide, (1-4C)alkoxy, (1-4C)alkoxycarbonylamino or (1-4C)alkylcarbonylamino or R 9 is (1-5C)heteroaryl, phenyl, (2-5C)heteroaryloxy or phenoxy, all optionally substituted with one or more substituents selected from R 14 or R 9 is (1-6C)alkylcarbonylamino, optionally substituted with hydroxy, amino, (2-5C)heterocycloalkyl or (di)[(1-4C)alkyl]amino or R 9 is phenyl substituted at two adjacent positions together representing a fused Oâ€”(CH 2 ) m â€”O ring wherein m is 1 or 2; R 10 is H, methoxy, halogen or methyl R 11 is H, (1-4C)alkyl or (2-4C)alkenyl; R 12 is (1-4C)alkylcarbonyl or (3-6C)cycloalkylcarbonyl, both optionally substituted with one or more substituents selected from R 15 ; R 13 is hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio or (di)[(1-4C)alkyl]amino; R 14 is hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio, (di)[(1-4C)alkyl]amino, (2-5C)heteroaryl, (di)[(1-4C)alkyl]aminocarbonyl, (1-4C)alkylcarbonylamino or (1-4C)alkylsulfonyl or R 14 is (2-5C)heterocycloalkyl optionally substituted with (1-4C)alkyl or (1-4C)alkoxycarbonyl; and R 15 is hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio or (di)[(1-4C)alkyl]amino.