Patent ID: 8541181

Claim:
A method for determining if cells of a tumor in an organ or in a tissue in a subject, are likely to invade another organ or tissue in the subject comprising determining if a sample of the tumor, or a sample obtained from the tumor, comprises human myosin-IIA heavy chain phosphorylated at residue S1943, comprising contacting the sample of the tumor, or the sample obtained from the tumor, with a detectable agent which comprises an antibody or an antigen-binding fragment of an antibody, which selectively binds to phosphorylated S1943 residue of human myosin-IIA heavy chain and detecting any bound detectable agent, wherein cells of the tumor are likely to invade another organ or tissue if the sample comprises the phosphorylated S1943 residue of human myosin-IIA heavy chain, and wherein absence of a phosphorylated S1943 residue of human myosin-IIA heavy chain does not indicate that cells of the tumor are likely to invade another organ or tissue.