Patent ID: 7064120

Claim:
A compound of the formula: wherein: R 1 and R 2 are, independently, selected from hydrogen, (C 1 –C 6 )lower alkyl, halogen, cyano, trifluoromethyl, hydroxy, amino, (C 1 –C 6 ) lower alkylamino, (C 1 –C 6 ) lower alkoxy, —OCF 3 , (C 1 –C 6 ) lower alkoxy carbonyl, —NHCO[(C 1 –C 6 )lower alkyl], carboxy, —CONH 2 , —CONH[(C 1 –C 6 ) lower alkyl], or —CON[(C 1 –C 6 ) lower alkyl] 2 ; R 3 is a substituent selected from hydrogen, (C 1 –C 6 ) lower alkyl, (C 1 –C 6 ) lower alkoxy, hydroxy, amino, (C 1 –C 6 ) lower alkylamino, CO lower alkyl (C 1 –C 6 ), or halogen; R 4 is the moiety B–C; wherein: B is selected from the group of: and C is selected from the group of: wherein: A is CH or N; R 5 , R 6 , R 7 , R 8 , R 9 , R 10 are, independently, selected from hydrogen, (C 1 –C 6 ) lower alkyl, (C 1 –C 6 ) lower alkoxy, (C 1 –C 6 ) lower alkylcarbonyl, (C 3 –C 6 ) lower alkenyl, (C 3 –C 6 ) lower alkynyl, (C 3 –C 8 ) cycloalkyl, formyl, cycloalkylcarbonyl, carboxy, alkoxycarbonyl, cycloalkyloxycarbonyl, aryl alkyloxycarbonyl, carbamoyl, —O—CH 2 —CH═CH 2 , halogen, halo lower alkyl, trifluoromethyl, OCF 3 , S(lower alkyl), —OC(O)N[lower alkyl] 2 , —CONH[lower alkyl], —CON[lower alkyl] 2 , lower alkylamino, di-lower alkylamino, lower alkyl di-lower alkylamino, hydroxy, cyano, trifluoromethylthio, nitro, amino, lower alkylsulfonyl, aminosulfonyl, lower alkylaminosulfonyl, phenyl or naphthyl; R 11 and R 12 are, independently, selected from the group of hydrogen, (C 1 –C 6 ) lower alkyl, (C 2 –C 6 ) lower alkenyl, (C 3 –C 6 ) lower alkynyl, hydroxy (C 1 –C 6 ) lower alkyl, alkoxy (C 1 –C 6 ) lower alkyl, acyloxy (C 1 –C 6 ) lower alkyl, cyclo lower alkyl, or aryl, optionally substituted by hydroxy, (C 1 –C 6 ) lower alkoxy, halogen, cyano, SO 2 [(C 1 –C 6 ) lower alkyl], or —S[(C 1 –C 6 ) lower alkyl]; and R is selected from the groups: wherein: R 13 is selected from hydrogen, (C 1 –C 6 ) lower alkyl, cyanoethyl or R 14 is selected from hydrogen or (C 1 –C 6 ) lower alkyl; R 15 is one or two substituents selected from the group of hydrogen, (C 1 –C 6 ) lower alkyl, halogen, trifluoromethyl, (C 1 –C 6 ) lower alkoxy, (C 1 –C 6 ) lower alkoxycarbonyl, or R 16 represents one to two substituents selected from hydrogen, or (C 1 –C 6 ) lower alkyl; m is an integer from 0 to 2; n is an integer from 1 to 2; and p is an integer from 0 to 1; or a pharmaceutically acceptable salt form thereof.