Patent ID: 7910314

Claim:
A method of determining, for a subject diagnosed as afflicted with a breast tumor, the likelihood of the subject suffering a recurrence of the tumor following primary treatment, which method comprises determining the amount of p66-She and/or phosphorylated Shc present in the cancerous cells of the tumor, and comparing the amount so determined to a standard, wherein the standard comprises the amount of p66-She and/or phosphorylated Shc present in the cancerous cells of a tumor from a subject with no recurrence of the tumor, and wherein low levels of p66-Shc compared to the levels of p66-She in the standard, high levels of phosphorylated Shc compared to the levels of phosphorylated Shc in the standard, and/or low levels of p66-Shc coupled with high levels of phosphorylated Shc compared to the levels of p66-Shc coupled with the levels of phosphorylated Shc in the standard indicates that the subject will suffer a recurrence of the tumor, thereby determining the likelihood of recurrence.