Patent ID: 6908908

Claim:
A compound of Formula (I): or an optical isomer, enantiomer, diastereomer, racemate or racemic mixture thereof, ester, prodrug form, or a pharmaceutically acceptable salt thereof, wherein A is selected from aryl, heterocyclyl, and C 1 -C 10 alkyl, said aryl, heterocyclyl, and C 1 -C 10 alkyl being optionally substituted with one or more members selected from the group consisting of halogen, OH, aryl, C 3 -C 8 cycloalkyl, C 1 -C 10 alkyl substituted with a halogen, C 1 -C 10 alkyl ether, heterocyclyl, carbonyl, oxime, —N(R 1 )(SO 2 R), —C(NNR 3 R 4 )R 1 , —COOR 1 , —CONR 1 R 2 , —OC(O)R 1 , —OC(O)OR 1 , —OC(O)NR 1 R 2 , —NR 1 R 2 , —NR 3 C(O)R 1 , —NR 3 C(O)OR 1 , and —NR 3 C(O)NR 1 R 2 , wherein R is selected from C 1 -C 6 alkyl, trifluoromethyl, phenyl, and substituted phenyl; R 1 and R 2 are independently selected from hydrogen, C 1 -C 10 alkyl, aryl, heterocyclyl, and alkylaryl, or R 1 and R 2 may be taken together to form a 5- to 10-member ring; and R 3 and R 4 are independently selected from hydrogen, C 1 -C 10 alkyl, aryl, heterocyclyl, alkylaryl, —C(O)R 1 , or —C(O)NR 1 R 2 ; Z 1 is selected from hydrogen, C 1 -C 6 alkyl, aryl, heterocyciyl, COOR 1 , CONR 1 R 2 , OH, C 1 -C 6 alkyl ether, —OC(O)R 1 , —OC(O)OR 1 , —OC(O)NR 1 R 2 , —NR 1 R 2 , —NR 3 C(O)R 1 , —NR 3 C(O)OR 1 , —NR 3 C(O)NR 1 R 2 , halogen, —C(O)R 1 , —C(NR 3 )R 1 , —C(NOR 3 )R 1 , and —C(NNR 3 R 4 )R 1 ; Z 2 is selected from hydrogen, halogen, C 1 -C 6 alkyl; Z 1 and Z 2 may together form a fused aromatic ring; n is an integer from 0 to 3; G is selected from —COOR 1 , —C(O)COOR 1 , —CONR 1 R 2 , —CF 3 , —P(O)(OR 1 )(OR 2 ), —S—R 8 , —O—R 8 , R 5 and R 6 are independently hydrogen or C 1 -C 6 alkyl; R 7 is hydrogen, C 1 -C 6 alkyl, or —C(O)R 5 ; R 8 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, and substituted C 1 -C 6 alkyl; and B is oxygen or —NR 5 ; E is selected from hydrogen, C 1 -C 6 alkyl and a moiety of the formula X is hydrogen or oxygen, with the proviso that when E is hydrogen and G is —COOH, —COOCH 3 , or a moiety of the formula of A is selected from the group consisting of aryl, heterocyclyl, substituted C 1 -C 6 alkyl and C 7 -C 10 alkyl, provided that when X is hydrogen, n is 1 and G is a moiety of the formula of A is selected from the group consisting of heterocyclyl, and C 7 -C 10 alkyl.