Patent ID: 8691832

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salts thereof; wherein W is selected from the group consisting of C 1 -C 6 alkyl, —OC 1 -C 6 alkyl, —NHC 1 -C 6 alkyl or or when taken together with R 1 , W—R 1 is hydrogen; X—Y is selected from the group consisting of —CH═CH—, —(CH 2 ) m CR 3 R 4 (CH 2 ) n — and —C R 3 R 4 C(O)—; R 1 is selected from the group consisting of aryl, heterocycle, aroyl, heteroaroyl, C 3 -C 10 cycloalkyl, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl; wherein the aryl, heterocycle, aroyl, heteroaroyl and C 3 -C 10 cycloalkyl are unsubstituted or substituted with 1-3 substituents from R 5 or when taken together with W, W—R 1 is hydrogen; R 2 is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, benzyl, heterocycle and C 1 -C 6 alkylheterocycle; wherein the C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, benzyl, heterocycle and C 1 -C 6 alkylheterocycle are unsubstituted or substituted with 1-3 substituents each independently selected from R 3 , R 4 and R 5 ; R 3 and R 4 are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkylC 3 -C 10 cycloalkyl, benzyl and aryl, wherein the C 1 -C 6 alkylC 3 -C 10 cycloalkyl, benzyl and aryl are unsubstituted or substituted with R 5 , or when taken together R 3 , R 4 and the carbon on which they are attached form a C 3 -C 10 cycloalkyl or 4-membered heterocycle; and R 5 is selected from the group consisting of hydrogen, halogen, C 1 -C 6 alkyl, halogen-substitutedC 1 -C 6 alkyl, —OH, C 1 -C 6 alkylOH, halogen-substitutedC 1 -C 6 alkylOH, —OC 1 -C 6 alkyl, —Ohalogen-substitutedC 1 C 6 alkyl, —COOH, —COOC 1 -C 6 alkyl, —C 1 -C 6 alkylCOOC 1 -C 6 alkyl, —C 1 -C 6 alkylCOOH, —OC 1 -C 6 alkylCOOH, —CN, C 1 -C 6 alkylCN, NH 2 , NHC 1 -C 6 alkyl, N(C 1 -C 6 alkyl) 2 , —NHCOOC 1 -C 6 alkyl, C 1 -C 6 alkylCONH 2 , —CONH 2 , —CONHC 1 -C 6 alkyl, —NHCOC 1 -C 6 alkyl, —CON(C 1 -C 6 alkyl) 2 , —NHSO 2 C 1 -C 6 alkyl, SO 2 aryl, —SO 2 C 1 -C 6 alkyl, C 1 -C 6 alkyl SO 2 C 1 -C 6 alkyl, aryl, —NHCOaryl, and —NHCOheterocycle; m and n are independently 0-3, wherein m+n>0.