Patent ID: 7579348

Claim:
A compound of formula I: wherein: R is hydrogen or is selected from the group consisting of (C 1-5 )alkyl, halo(C 1-8 )alkyl, (C 3-8 )cycloalkyl, (C 3-8 )cycloalkyl(C 1-8 )alkyl-, (C 3-5 )alkenyl and (C 3-5 )alkynyl, each substituted or unsubstituted; R 1 and R 2 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted (C 1-8 )alkyl, halo(C 1-8 )alkyl, (C 3-8 )alkenyl, (C 3-8 )alkenyl(C 1-8 )alkyl, (C 3-8 )alkynyl, (C 3-8 )alkynyl(C 1-8 )alkyl, (C 1-8 )alkoxy, (C 3-8 )cycloalkyl, (C 3-8 )cycloalkyl(C 1-8 )alkyl, (C 4-10 )heterocyclyl, (C 4-10 )heterocyclyl(C 1-8 )alkyl, (C 6-10 )aryl, (C 6-10 )aryloxy, (C 6-10 )aryl(C 1-8 )alkyl-, (C 5-10 )heteroaryl and (C 5-10 )heteroaryl(C 1-8 )alkyl-; L 1 is a linker selected from the group consisting of substituted or unsubstituted——NR o —C(O)—, —NCH 3 —C(O)—, —C(O)NR o —, —C(O)NCH 3 —, —NR o C(O)CH 2 —, —NR o C(O)CH 2 CH 2 —, —C(O)NR o CH 2 —, —C(O)NR o CH 2 CH 2 —, —C(O)CH 2 NR o —, —C(O)CH 2 CH 2 NR o —, —CH 2 NR o C(O)—, —CH 2 CH 2 NR o C(O)—, —CH 2 C(O)NR o —, —CH 2 CH 2 C(O)NR o —, —NR o CH 2 C(O)—, and —NR o CH 2 CH 2 C(O)—, wherein each R o is independently hydrogen or substituted or unsubstituted (C 1-4 )alkyl, (C 1-4 )alkylC(O)—, (C 6-10 )arylC(O)— and (C 5-10 )heteroarylC(O)—; Z is a 5-14 member substituted or unsubstituted heteroaryl ring selected from the group consisting of benzo[b]furan, benzo[b]thiophene, benzimidazole, imidazo[4,5-c]pyridine, quinazoline, thieno[2,3-c]pyridine, thieno[3,2-]pyridine, thieno[2,3-b]pyridine, indolizine, imidazo[1,2a]pyridine, quinoline, isoquinoline, phthalazine, quinoxaline, naphthyridine, quinolizine, indole, isoindole, indazole, indoline, benzoxazole, benzopyrazole, benzothiazole, imidazo[1,5-a]pyridine, pyrazolo[1,5-a]pyridine, pteridine, purine, carbazole, and acridine; Z 1 is a 5-14 member substituted or unsubstituted aryl or heteroaryl ring; where n is 1 or 2; or a pharmaceutically acceptable salt thereof.