Patent ID: 8841096

Claim:
A process for aminating at least one keto group in a multicyclic ring system comprising at least one keto group to give an amino group, the method comprising: contacting the multicyclic ring system with at least one enzyme E with transaminase activity, wherein the enzyme E with transaminase activity comprises the polypeptide sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 27, SEQ ID NO: 29, and SEQ ID NO: 31, or a functional equivalent of the enzyme comprising SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 27, SEQ ID NO: 29, and SEQ ID NO: 31, wherein up to 5% of the amino acid residues have been modified over the corresponding sequence of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 27, SEQ ID NO: 29 and SEQ ID NO: 31 respectively, by deletion, insertion, substitution, insertion or a combination of deletion, substitution and insertion and which retains at least 50% of the enzymatic activity of the corresponding enzyme of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 27, SEQ ID NO: 29, and SEQ ID NO: 31, respectively.