Patent ID: 7625932

Claim:
A compound of Formula I: wherein X represents N or CR 1 ; R represents hydrogen, methyl, ethyl, n-propyl, or —SO 2 (1-4C)alkyl; R 1 represents hydrogen, F, Cl, Br, I, CHO, —CN, —S(phenyl), CF 3 , -(1-4C)alkyl, -(1-4C)alkoxy, —S(1-4C)alkyl, —SO(1-4C)alkyl, —SO 2 (1-4C)alkyl, —C(═O)(1-3C)alkyl, NH 2 , —NH(1-4C)alkyl, —N[(1-4C)alkyl] 2 , or —NH(4-7C)cycloalkyl; R 2 represents —CO 2 H, —C(═O)NHR 13 ; —C(═O)NHOH, and —C(═O)NHCN; R 4 represents hydrogen, OH, —CH 2 OH, —CH 2 O(1-4C)alkyl, F, Cl, CF 3 , OCF 3 , —CN, NO 2 , NH 2 , -(1-4C)alkyl, -(1-4C)alkoxy, —C(═O)NH(1-4C)alkyl, —C(═O)NH 2 , —NHC(═O)(1-4C)alkyl, —(CH 2 ) m NHSO 2 R 10 , —(CH 2 ) n CN, —(CH 2 ) m CO 2 H, —(CH 2 ) m CO 2 (1-6C)alkyl, —C(═O)H, —C(═O)(1-4C)alkyl, —NH(1-4C)alkyl, —N[(1-4C)alkyl] 2 , —SR 10 , —SOR 10 , —SO 2 R 10 , or SH; R 5 represents hydrogen; F, Cl, —CN, NO 2 , NH 2 , —(CH 2 ) m NHSO 2 R 10 , -(1-4C)alkyl, or -(1-4C)alkoxy; R 8 represents hydrogen, F, Cl, Br, -(1-4C)alkyl, -(1-4C)alkoxy, NO 2 , NH 2 , —CN, —NHSO 2 R 11 , or —C(═O)(1-4C)alkyl; R 10 , R 11 , and R 12 each independently represent -(1-4C)alkyl, CF 3 , N[(1-4C)alkyl] 2 , —(CH 2 ) 3 Cl, thienyl, phenyl, —CH 2 phenyl, or —(CH 2 ) 2 phenyl, wherein phenyl, as used in substituent R 10 , R 11 or R 12 , is unsubstituted or substituted with F, Cl, Br, —CN, CF 3 , -(1-4C)alkyl, -(1-4)alkoxy, or acetyl; R 13 represents hydrogen, -(1-4C)alkyl, —CH 2 CF 3 , triazole, or tetrazole; A is selected from the group consisting of and the pharmaceutically acceptable salts thereof, with the proviso that when R is methyl, X is CR 1 wherein R 1 is SCH 3 , and R 2 is CO 2 H, A is other than 4-tert-butyl-phenyl; and provided that when R is methyl, X is CR 1 wherein R 1 is hydrogen, and R 2 is CO 2 H, A is other than 2,6-dimethylphenyl.