Patent ID: 6991805

Claim:
A composition for temperature controlled cell surface adhesion of liposomes comprising a) poloxamer molecules; and b) liposomes encapsulating a delivery agent, wherein the concentration of the poloxamer in the composition is between 0.01% w/v to 0.2% w/v wherein the critical micellar temperature (CMT) of the poloxamer at a concentration between 0.01% to 0.2% is between 33° C. and 43° C. wherein at above the CMT of the poloxamer, a fraction of the poloxamer molecules forms micelles and another fraction of the poloxamer molecules becomes incorporated into the liposomal bilayers, wherein the concentration of the poloxamer is such that the incorporation of the poloxamer molecules into the liposomal bilayer does not make the liposome leaky, but is sufficient to inhibit the liposome from adhering to cell surfaces, and wherein at below the CMT, the poloxamer molecules are dissociated from the liposome into monomers, allowing the liposomes to adhere to cell surfaces.