Patent ID: 8669249

Claim:
A compound of the formula: a tautomer thereof, or a pharmaceutically acceptable salt of the compound or tautomer, wherein: X is O; R 1 is -L 1 -R 9 ; R 2 is selected from the group consisting of hydrogen, halo, and (C 1-3 )alkyl; R 3 is selected from the group consisting of hydrogen, halo, hydroxy, (C 1-3 )alkyl, (C 1-3 )alkoxy, and aryl(C 1-10 )alkyl; R 4 is selected from the group consisting of hydrogen, halo, and (C 1-3 )alkyl; R 5 is methyl; R 6 is hydrogen; R 7 is selected from the group consisting of hydrogen, halo, and (C 1-3 )alkyl; L 1 is selected from the group consisting of —CH 2 — and; R 9 is selected from the group consisting of R 16 and R 17 are each independently selected from the group consisting of (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 6-12 )aryl, (C 1-10 )heteroaryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each unsubstituted or substituted through available valencies with one or more substituents independently selected from the group consisting of halo, nitro, cyano, oxo, hydroxy, (C 1-10 )alkoxy, carbonyl, amido, amino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, sulfonyl(C 1-10 )alkyl, and (C 6-12 )aryl, wherein carbonyl, amido, and amino are each independently substituted with hydrogen, hydroxy, (C 1-10 )alkoxy, (C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl or (C 6-12 )aryl.