Patent ID: 7544790

Claim:
An isolated nucleic acid encoding the heavy chain of a CDR-grafted antibody capable of inhibiting human tissue factor, wherein the complementarity determining regions (CDRs) are obtained from a murine monoclonal antibody against human tissue factor and the constant (C) and framework (FR) regions are obtained from one or more human antibodies, wherein said CDRs of the heavy chain have the amino acid sequences: CDR1 DYYMH (SEQ ID NO: 5) CDR2 LIDPENGNTIYDPKFQG (SEQ ID NO: 6) CDR3 DNSYYFDY (SEQ ID NO: 7) and said CDRs of the light chain have the amino acid sequences: CDR1 KASQDIRKYLN (SEQ ID NO: 8) CDR2 YATSLAD (SEQ ID NO: 9) CDR3 LQHGESPYT (SEQ ID NO: 10) wherein the heavy chain comprises residues obtained from the murine monoclonal antibody at positions 23, 24, 28, 29, 30, 48, 49, 71, 88 and 91 and the light chain comprises residues obtained from the murine monoclonal antibody at positions 39 and 105, wherein the residues are numbered according to the Kabat numbering system.