Patent ID: 7407939

Claim:
A compound of Formula I: wherein: R 1 and R 2 are independently selected from the group consisting of hydrogen, a lower alkyl group, a lower alkoxy group, substituted or unsubstituted phenyl group, a lower alkyl substituted with at least one substituent selected from the group consisting of a phenyl group, a halogen, hydroxyl, thiol, nitro, cyano, or amino group; m and n are each independently 0-3; X is selected from the group consisting of SO 2 —NH, S and O; M represents substituted or unsubstituted alkylene of 1-4 carbon atoms; Y is selected from the group consisting of amide, amine, urea, carbamate, hydrazine or sulfonamide; Z is Arg-Pro-Arg-R 4 -R 5 -R 6 -R 7 ; R 4 , R 5 , and R 6 are each independently selected from the group consisting of threonine, serine, glutamic acid allyl ester, homocitrulline, lysine, methionine, norleucine, ornithine, arginine, glycine, diaminopropionic acid, diaminobutyric acid, GlyNH 2 , and alanine; or are an N α -ω-functionalized derivative of an amino acid selected from the group of glycine, alanine and tyrosine; R 7 is selected from the group consisting of phenylalanine, homoleucine, norleucine, glutamic acid allyl ester; W may be absent so that Y is connected to L or R 4 , or W is N-(8-sulfonamide-5-isoquinoline) ethylenediamine; and L may be absent so that W (if present) or Y is connected to R 4 , or L is selected from the group consisting of glycine, β-alanine, phenylalanine, aminobutyric acid and aminopentanoic acid and connects W (if present) or Y with R 4 .