Patent ID: 7220754

Claim:
A mono-ester or asymmetrically substituted di-ester pro-drug of a dopamine D 1 agonist selected from the following formulas: wherein one of R 1 and R 2 is hydrogen or acetyl and the other one is selected from the group consisting of (C 3 –C2)alkanoyl; halo-(C 3 –C 20 )alkanoyl; (C 3 –C 20 )alkenoyl; (C 4 –C7)cycloalkanoyl; (C 3 –C6)-cycloalkyl(C 2 –C 16 )alkanoyl; aroyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, cyano, trifluoromethanesulphonyloxy, (C 1 –C 3 )alkyl, and (C 1 –C 3 )alkoxy, which latter may in turn be substituted by 1 to 3 halogen atoms; aryl(C 2 –C 16 )alkanoyl which is unsubstituted or substituted in the aryl moiety by 1 to 3 substituents selected from the group consisting of halogen, (C 1 –C 3 )alkyl, and (C 1 –C 3 )alkoxy, which latter may in turn be substituted by 1 to 3 halogen atoms; and hetero-arylalkanoyl having one to three heteroatoms selected from oxygen, sulfur, and nitrogen in the heteroaryl moiety and 2 to 10 carbon atoms in the ailcanoyl moiety and which is unsubstituted or substituted in the heteroaryl moiety by 1 to 3 substituents selected from the group consisting of halogen, cyano, trifluoromethanesulphonyloxy, (C 1 –C 3 )alkyl, and (C 1 –C 3 )alkoxy, which latter may in turn be substituted by 1 to 3 halogen atoms, and the physiologically acceptable salts thereof; providing that in Formula I, when one of R 1 and R 2 is hydrogen, the other one of R 1 and R 2 is not pivaloyl or benzoyl.