Patent ID: 8916714

Claim:
A production method comprising reacting a compound represented by the following formula (1) (wherein in formula (1), R 1 represents a hydrogen atom or halogen atom; R 2 represents a hydrogen atom, a cyano group, a nitro group, a halogen atom, a formyl group or a halomethyl group; A represents a hydrogen atom, a C 1 to C 8 alkyl group, a C 3 to C 6 cycloalkyl group, a phenyl group, a fluorine atom (only when X is bond), or protecting group for a hydroxyl group (only when X is an oxygen atom), A may be substituted with 1 to 3 substituents, such substituents include a group selected from the group consisting of a halogen atom, a C 1 to C 4 alkyl group, a C 1 to C 4 alkoxy group, a C 1 to C 4 alkylthio group, a C 3 to C 6 cycloalkyl group, a phenyl group, a phenoxy group, and a pyridyl group; X represents a bond (only when A is a phenyl group or a fluorine atom), or an oxygen atom; and Y represents a leaving group), and a compound represented by the following formula (2) (wherein in formula (2), H represents a hydrogen atom; R 3 represents a —COOR 3a or —COR 3b ; R 3a represents a hydrogen atom, a C 1 to C 4 alkyl group, or an ester protecting group of a carboxyl group; R 3b represents an amide-type protecting group of a carboxyl group formed an amide with an adjacent carbonyl group; and R 4 represents a hydrogen atom, a halogen atom, or C i to C 4 alkyl, in the presence of (i) a palladium compound, (ii) a ligand capable of coordinating to the palladium compound or a salt thereof, (iii) a base, (iv) a C 1 to C 40 carboxylic acid or a salt thereof (v) at least one additive selected from the group of consisting of copper, silver, and salts thereof, and complexes thereof; to produce a phenyl-substituted heterocyclic derivative represented by the following formula (3) (Wherein in formula (3), the definition of A, X, R 1 and R 2 is the same as defined in formula (1), and that of R 3 and R 4 is the same as in formula (2)).