Patent ID: 7998922

Claim:
A process for treating fibroses comprising administering a therapeutically effective amount of a pharmaceutical composition comprising at least one biocompatible polymer having the general formula (I): A a X x Y y Z z , wherein A is a glucose monomer; X is —CH 2 —COOH or —CH 2 —COO—Na + ; Y is SO 3 ; Z is selected from the group consisting of: phenylalanine, tyrosine, phenylalanine methylester and tyrosine methylester; a represents the number of monomers A such that the mass of said at least one biocompatible polymer of formula (I) is greater than approximately 5,000 Da; x represents the substitution rate of the monomers A by the group X, and x is 28.9% when Z is phenylalanine or phenylalanine methylester and 19.8% when Z is tyrosine or tyrosine methylester; y represents the substitution rate of the monomers A by the group Y, and y is 56.2% when Z is phenylalanine or phenylalanine methylester and 65.9% when Z is tyrosine or tyrosine methylester; and z represents the substitution rate of the monomers A by the group Z and z is 17.9% when Z is phenylalanine or phenylalanine methylester and 28.9% when Z is tyrosine or tyrosine methylester, wherein when Z is phenylalanine or phenylalanine methylester, A is a glucose monomer on which X is grafted by the intermediary of the hydroxyl function in position 2, Y is bonded to the nitrogen of Z or grafted by the intermediary of the hydroxyl function in positions 3 or 4 of A, and Z is bonded to X, and wherein when Z is tyrosine or tyrosine methylester, A is a glucose monomer on which X is grafted by the intermediary of the hydroxyl function in position 2, Y is bonded to the nitrogen and hydroxyl group of Z or grafted by the intermediary of the hydroxyl function in positions 3 or 4 of A, and Z is bonded to X, and wherein in an in vitro assay of pig aorta smooth muscle cells cultured on a medium with fetal calf serum, L-glutamine, and penicillin-streptomycin, said at least one biocompatible polymer decreases the rate of Type I and Type III collagen synthesis and increases the secretion of Type V collagen by the pig aorta smooth muscle cells.