Patent ID: 7338974

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R 1 is hydrogen, C 1-6 alkyl or NHR 3 ; R 2 is hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 cycloalkyl or C 3-6 cyloalkyl(C 1-4 alkyl) in which each group is optionally substituted with a group selected from halogen, CF 3 , CF 2 H, OH, OCF 3 and C 1-4 alkoxy; R 3 is —C(═O)R 9 , —C(═O)OR 9 , —C(═O)NHR 9 , or C 1-6 alkyl optionally substituted with a group selected from C 3-6 cycloalkyl, halogen, CF 3 , OCF 3 , OH, C 1-4 alkoxy and CN; R 4 is C 1-6 alkyl, phenyl or phenyl(C 1-4 alkyl) in which each group is optionally substituted with one to two groups selected from halogen, C 1-4 alkyl, OH, CF 3 , OCF 3 and CN; R 5 is hydrogen, halogen, C 1-4 alkyl, OH, C 1-4 alkoxy, CF 3 , CF 2 H, OCF 3 or CN; n is 0, 1 or 2; Z is O or NR 6 ; R 6 is hydrogen or C 1-4 alkyl; L is —CH(R 7 )—CH(R 8 )— or —C(R 7 )═C(R 8 )—; R 7 and R 8 are each independently hydrogen or methyl; and R 9 is C 1-4 alkyl optionally substituted with the group selected from halogen, OH, CF 3 , NH 2 and C 1-4 alkoxy; or a nontoxic pharmaceutically acceptable salt thereof.