Patent ID: 8222414

Claim:
An indole compound of the following formula (1): in which n denotes a number of 0 to 3, A represents 5 membered heteroaryl or heterocycle each of which has 1 to 3 hetero atoms selected from N, O and S, R 1 represents R 5 —X—B—X′—, B represents a direct bond, or represents 3˜10 membered heterocycle or heteroaryl each of which has 1 to 4 hetero atoms selected from N, O and S, X and X′ independently of one another represent a direct bond, or are selected from the group consisting of —NR 6 —, —CO—, —CONR 6 —, —CO 2 —, —OC(O)—, —S(O) m —, —O—(CH 2 ) m —, —(CH 2 ) m —O—, —(CH 2 ) m —, —NR 6 CO—, —(R 6 O) 2 P(O)— and —NHCO 2 —, wherein m denotes a number of 0 to 3, and R 6 represents hydrogen or alkyl, R 5 represents hydrogen, hydroxy, alkyl, alkoxy, cycloalkyl or 4˜10 membered aryl, or represents 3˜10 membered monocyclic or fused cyclic heterocycle or heteroaryl each of which has 1 to 3 hetero atoms selected from N, O and S, and is optionally substituted by oxo or alkyl, or R 2 represents —(CR 8 R 9 ) p —Y—R 7 , p denotes a number of 0 to 2, R 8 and R 9 independently of one another represent hydrogen or alkyl, Y represents a direct bond, or is selected from the group consisting of —O—, —S—, —NR 6 —, —NR 6 C(O)—, C(O)NR 6 — and —S(O) q —, wherein q denotes a number of 0 to 2, R 7 represents hydrogen, halogen, hydroxy, alkyl, 4˜10 membered aryl, or represents 3˜10 membered heterocycle or heteroaryl each of which has 1 to 3 hetero atoms selected from N, S and O and which optionally contains oxo, R 3 represents hydrogen, alkyl, or —(CH 2 ) q -cycloalkyl, R 4 represents cycloalkyl, where alkyl, alkoxy, aryl, cycloalkyl, heterocycle and heteroaryl may be optionally substituted, and the substituents are one or more selected from the group consisting of hydroxy, halogen, nitrile, amino, alkylamino, dialkylamino, alkyl, haloalkyl, alkylsulfonyl, carboxyalkyl, alkylcarbonyloxy, alkylthio, alkyloxycarbonyl, alkylaminocarbonyl, arylalkoxy and oxo, or pharmaceutically acceptable salt or stereoisomer thereof.