Patent ID: 7247634

Claim:
A rifamycin compound having a structural formula I or II: wherein, A is a quinolone or its pharmacophore, covalently coupled to a linker group “X”; X is a linker group that is covalently coupled to both rifamycin moiety at C-3 position and “A”, wherein “X” is selected from one or a combination of 1 to 3 of the following structural elements: a) —(C 1 -C 6 )alkylene, b) —(C 1 -C 6 )alkenylene, c) —(C 1 -C 6 )alkynylene, d) —(C 3 -C 8 )cycloalkylene, e) —O—, f) —C(H)═N—, provided the group was not directly attached to the C-3 position of the rifamycin moiety, g) —C(═O)—, h) —C(═N—O—R 13 )—, wherein R 13 represents hydrogen, (C 1 -C 6 )alkyl, or substituted (C 1 -C 6 )alkyl, i) —S(O) n —, wherein n is a number between 0 and 2, j) —N(R 14 )—, wherein R 14 represents hydrogen, (C 1 -C 6 )alkyl, or substituted (C 1 -C 6 )alkyl, and k) arylene, wherein, the carbon or nitrogen atoms of the linker group “X” can be substituted by 1 to 3 substituents selected from (C 1 -C 6 )alkyl, substituted (C 1 -C 6 )alkyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, hydroxyl, and (C 1 -C 6 )alkoxy; R 1 is hydrogen, or acetyl, or a pharmaceutically acceptable salt of the structural formula I or II.