Patent ID: 8257931

Claim:
A method of inhibiting preferentially cap-dependent protein synthesis in a breast cancer cell, a prostate cancer cell, a lung cancer cell, a pancreatic cancer cell or a colon cancer cell, comprising contacting said cell with a compound of the formula wherein R 1 is a hydrazone thiazole moiety of the structure R 2 is hydrogen, hydroxyl or a nitro group present in one, two or three locations on the ring to which it is attached; R 3 is a group individually present in one, two or three locations on the ring, wherein the group may be halo, hydrogen, conjugated or unconjugated aryl or heteroaryl, a alicyclic or polycyclic group, or R 3 , taken with the ring to which it is attached, forms a conjugated ring structure; R 4 is hydrogen, carboxyl, a lower alkyl ester or carbonyl, in which case the dotted bond is present; R 5 is N, in which case the dotted bond is present, or NH; and R 6 is NH.