Patent ID: 6916813

Claim:
A compound having the formula (I): or a pharmaceutically-acceptable salt or hydrate, thereof, wherein: R 1 is cyano, —SO 2 R 8 , —C(═O)R 9 , or heteroaryl; R 2 is (i) independently hydrogen, alkyl, or substituted alkyl, or (ii) taken together with R 3 forms a heterocyclo; R 3 is (i) independently alkyl, substituted alkyl, alkylthio, aminoalkyl, carbamyl, A-aryl, A-heterocyclo, A-heteroaryl, or A-cycloalkyl, or (ii) taken together with R 2 forms a heterocyclo; Z is heteroaryl provided that when R 1 is cyano, Z is not 2-pyridinyl; A is a bond, C 1-4 alkylene, C 2-4 alkenylene, substituted C 1-4 alkylene, substituted C 2-4 alkenylene, —C(═O)NR 19 —, —C 1-4 alkylene-C(═O)NR 19 —, or substituted C 1-4 alkylene-C(═O)NR 19 —: R 4 at each occurence is selected independently of each other R 4 from the group consisting of halogen, alkyl, substituted akyl, haloalkyl, nitro, cyano, haloalkoxy, OR 25 , SR 25 , NR 25 R 26 , NR 25 SO 2 R 27 , SO 2 R 27 , SO 2 NR 25 R 26 , CO 2 R 26 , C(═O)R 26 , C(═O)NR 25 R 26 , OC(═O)R 25 , —OC(═O)NR 25 R 26 , NR 25 C(═O)R 26 , NR 25 CO 2 R 26 , aryl, heteroaryl, heterocyclo and cycloalkyl; R 9 is —NR 10 R 11 , alkyl, substituted alkyl, alkoxy, alkylthio, cyoloalkyl, aryl, heteroaryl, heterocyclo, or —CO 2 R 12 ; R 10 and R 11 are (i) independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, heterocyclo, cycloalkyl, aryl, and heteroaryl;or (ii) taken together form a heterocyclo or heteroaryl; R 12 and R 19 are hydrogen or alkyl; R 25 and R 26 are independently selected from hydrogen, alkyl, or substitizted alkyl, or taken together form a heterocyclo or heteroaryl ring; R 27 is alkyl or substituted alkyl, and q is 0, 1, 2, or 3.