Patent ID: 7704992

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein u and u′ are independently 0, 1, 2, or 3; D and E are each five-membered aromatic rings containing one, two, or three heteroatoms independently selected from nitrogen, oxygen, and sulfur; each R 1 and R 1′ is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, arylalkoxycarbonyl, carboxy, formyl, halo, haloalkyl, hydroxy, hydroxyalkyl, —NR a R b , (NR a R b )alkyl, and (NR a R b )carbonyl; R 2 and R 2′ , together with the carbon atoms to which they are attached, form a five- to eight-membered unsaturated ring optionally containing one or two heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein the five- to eight-membered unsaturated ring is optionally substituted with one, two, or three substituents independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylsulfonyl, aryl, arylalkyl, arylsulfonyl, carboxy, formyl, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, —NR a R b , (NR a R b )alkyl, (NR a R b )carbonyl, oxo, and spirocycle; R 3 and R 3′ are each independently selected from hydrogen, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, arylalkoxycarbonyl, carboxy, haloalkyl, heterocyclylalkyl, hydroxyalkyl, (NR a R b )carbonyl, and trialkylsilylalkoxyalkyl; R 4 and R 4′ are each independently selected from each m is independently 0, 1, or 2; each o is independently 1, 2, or 3; each s is independently 0, 1, 2, 3, or 4; each X is independently selected from O, S, S(O), SO 2 , CH 2 , CHR 5 , and C(R 5 ) 2 ; provided that when n is O, X is selected from CH 2 , CHR 5 , and C(R 5 ) 2 ; each R 5 is independently selected from alkoxy, alkyl, aryl, halo, haloalkyl, hydroxy, and —NR a R b , wherein the alkyl can optionally form a fused three- to six-membered ring with an adjacent carbon atom, wherein the three- to six-membered ring is optionally substituted with one or two alkyl groups; each R 6 is independently selected from hydrogen and R 10 —C(O)—, and R 10 —C(S)—; R 7 is selected from hydrogen and alkyl; R 8 and R 9 are each independently selected from hydrogen, alkenyl, alkoxyalkyl, alkyl, haloalkyl, and (NR a R b )alkyl; or, R 8 and R 9 , together with the carbon atom to which they are attached, form a five or six membered saturated ring optionally containing one or two heteroatoms selected from NR z , O, and S; wherein R z is selected from hydrogen and alkyl; and each R 10 is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonylalkyl, aryl, arylalkenyl, arylalkoxy, arylalkyl, aryloxyalkyl, cycloalkyl, (cycloalkyl)alkenyl, (cycloalkyl)alkyl, cycloalkyloxyalkyl, haloalkyl, heterocyclyl, heterocyclylalkenyl, heterocyclylalkoxy, heterocyclylalkyl, heterocyclyloxyalkyl, hydroxyalkyl, —NR c R d , (NR c R d )alkenyl, (NR c R d )alkyl, and (NR c R d )carbonyl.