Patent ID: 7259165

Claim:
A compound of formula I wherein W is CR 2 ; X is N or CR 4 ; Y is N or CR 5 ; Z is N or CR 6 ; Q is N or CR 7 with the proviso that one and only one of X, Y, Z and Q must be N; R 1 is an optionally substituted C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, aryl, or heteroaryl group or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S; R 2 is H, halogen, or a C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 3 -C 7 cycloalkyl, aryl or heteroaryl group each optionally substituted; R 3 is H or a, C 3 -C 7 cycloalkyl, aryl or heteroaryl group each optionally substituted; R 4 , R 5 , R 6 and R 7 are each independently H, halogen, CN, COR 8 , OCO 2 R 9 , CO 2 R 10 , CONR 11 R 12 , SO n R 13 , NR 14 R 15 , OR 16 or a C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, aryl or heteroaryl group each optionally substituted or a group M having the structure with the proviso that at least one of R 4 , R 5 , R 6 or R 7 must be a group M and with the further proviso that when W is CR 2 and X or Z is N, then R 7 must be other than a group M; R 8 , R 9 , R 10 and R 13 are each independently H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 11 , R 12 , R 14 and R 15 are each independently H or an optionally substituted C 1 -C 4 alkyl group or R 11 and R 12 or R 14 and R 15 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, NR 22 or SO n ; R 16 is H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; n is 0 or an integer of 1 or 2; R 17 is H or a C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl group each optionally substituted; R 18 , R 19 , R 20 , R 21 and R 23 are each independently H or a C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl group each optionally substituted; m is 1 or 2; and R 22 is H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.