Patent ID: 7078226

Claim:
A process for preparing compounds of the formula I which comprises the following process steps: a) A reaction of compounds of the formula II with compounds of the formula R 2 —XH (III) in the presence of a base to give compounds of the formula IV b) A reaction of the reaction solution of compounds of the formula IV with a compound of the formula NH 2 R 3 (V) to give compounds of the formula VI c) A hydrogenation of compounds of the formula VI in the presence of a hydrogenation catalyst to give compounds of the formula VII d) A resolution of a racemate of compounds of the formula VII using an optically active carboxylic acid or esters of the formula VIII in the presence of a lipase or esterase, giving compounds of the formula I where the substituents and variables in the formulae I, II, III, IV, V, VI VII and VIII are as defined below: R 1 is substituted or unsubstituted, branched or unbranched C 1 –C 10 -alkyl, C 2 –C 10 -alkenyl, C 2 –C 10 -alkynyl, arylalkyl, aryl, hetarylalkyl or hetaryl, R 2 is substituted or unsubstituted, branched or unbranched C 1 –C 10 -alkyl, C 3 –C 10 -alkenyl, C 3 –C 10 -alkynyl, arylalkyl, aryl, hetarylalkyl or hetaryl, R 3 is hydrogen, hydroxyl, substituted or unsubstituted, branched or unbranched C 1 –C 10 -alkyl, C 3 –C 10 -alkenyl or C 3 –C 10 -alkynyl, R 4 is substituted or unsubstituted, branched or unbranched C 1 –C 10 -alkyl, R 5 is hydrogen, substituted or unsubstituted, branched or unbranched C 1 –C 10 -alkyl, R 6 is hydrogen, substituted or unsubstituted, branched or unbranched C 1 –C 10 -alkyl or substituted or unsubstituted phenyl, X=oxygen or nitrogen, n=0 or 1.