Patent ID: 8846836

Claim:
A method of treating a disorder selected from the group consisting of atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof, comprising: implanting in a human being an implantable device comprising a bioactive agent and a hyaluronic acid (HA) conjugate with a biocompatible polymer, wherein the HA is functionalized to bear a hydrazide group, a terminal anhydride group, a terminal aldehyde group, or a combination thereof, wherein the HA conjugate with a biocompatible polymer is formed by coupling the functionalized HA with the biocompatible polymer; and wherein the biocompatible polymer is selected from the group consisting of poly(tyrosine carbonates) and derivatives thereof; poly(tyrosine ester) and derivatives thereof; poly(imino carbonates); poly(n-butyl methacrylate) (PBMA); and combinations thereof.