Patent ID: 8592432

Claim:
A compound of Formula (1): or a physiologically acceptable salt thereof; R 1 and R 2 are independently H, C 1-6 alkyl or halo-substituted C 1-6 alkyl; R 3 is halo, C 1-6 alkyl, or a halo-substituted C 1-6 alkyl; R 4 is H; alternatively, R 3 and R 4 together with the carbon atoms to which they are attached may form a 5-6 membered ring containing 1-3 heteroatoms selected from N, O and S, and optionally substituted with 1-2 R 10 groups wherein R 10 is halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, optionally substituted phenyl or NR 2 ; R 5 and R 6 are independently C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl or C 2-6 alkynyl, each of which may be optionally substituted with halo, amino or hydroxyl groups; halo, nitro, cyano, CR(OR 17 )R 17 , OR 17 , NR(R 17 ), CR(R 17 )NRR 17 , (CR 2 ) q Y, C(O)O 0-1 R 17 , C(O)NR(R 17 ), C(O)CRR 17 —NR(R 17 ), C(O)NR(CR 2 ) p NR(R 17 ), C(O)NR(CR 2 ) p OR 17 , C(O)NR(CR 2 ) p SR 17 , C(O)NR(CR 2 ) p S(O) 1-2 R 18 , S(O) 0-2 R 18 , (CR 2 ) 1-6 NR(CR 2 ) p OR 17 , (CR 2 ) 1-6 NR(CR 2 ) q C(O)R 18 , S(O) 2 NRR 17 , S(O) 2 NR(CR 2 ) p NR(R 17 ), or S(O) 2 NR(CR 2 ) p OR 17 ; R 7 is S(O) 0-2 R 19 , S(O) 2 NRR 20 or C(O)NR(R 20 ); wherein R 19 and R 20 are independently C 1-6 alkyl, halo-substituted C 1-6 alkyl or C 3-7 cycloalkyl; or R 20 is H; each R 9 is independently -L-CR(OR 17 )—C t F (2t+1) wherein t is 1-3; -L-C(O)—CR(R 17 )—NRR 17 , -L-C(O)—NR—(CR 2 ) p —NRR 17 , -L-C(O)NR(CR 2 ) p OR 17 , -L-C(O)—(CR 2 ) q —NR—C(O)—R 18 , -L-C(O)NR(CR 2 ) p SR 17 , -L-C(O)NR(CR 2 ) p S(O) 1-2 R 18 , (CR 2 ) p NR(CR 2 ) p OR 17 or (CR 2 ) p NR-L-C(O)R 18 , -L-S(O) 2 R 18 , -L-S(O) 2 NRR 17 , -L-S(O) 2 NR(CR 2 ) p NR(R 17 ), or -L -S(O) 2 NR(CR 2 ) p OR 17 ; or R 9 is selected from formula (a), (b), (c) or (d): wherein R 11 ,R 12 ,R 13 , R 14 , R 15 and R 16 are independently selected from H, or C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl or C 2-6 alkynyl, each of which may be optionally substituted with halo, amino or hydroxyl groups; or R 11 and R 12 , R 12 and R 15 , R 15 and R 16 , R 13 and R 14 , or R 13 and R 15 together with the carbon and/or nitrogen atoms to which they are attached may form a 3-7 membered saturated, unsaturated or partially unsaturated ring optionally containing up to 3 atoms or groups selected from C(O), N, O and S(O) 0-2 ; L is (CR 2 ) 1-4 or a bond; R 17 and R 18 are independently C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; or R 17 is H; Y is a C 3-12 carbocyclic ring, C 6-10 aryl; or a 5-10 membered heteroaryl or 4-10 membered heterocyclic ring; each of which is optionally substituted with 1-3 R 6 groups; each R is H or C 1-6 alkyl; p is 2-4; and q is 0-4.