Patent ID: 8778615

Claim:
A method for evaluating renal status in a subject, comprising: performing an immunoassay configured to detect Tissue inhibitor of metalloproteinase 2 by introducing a urine sample obtained from the subject into an assay instrument which contacts the urine sample with an antibody which specifically binds for detection Tissue inhibitor of metalloproteinase 2 and generates an assay result indicative of binding of Tissue inhibitor of metalloproteinase 2 to the antibody; and correlating the assay result generated by the assay instrument to a likelihood that the subject is at risk of a future acute renal injury by using assay result to assign the patient to a predetermined subpopulation of individuals having a known predisposition of a future renal injury; and treating the patient based on the predetermined subpopulation of individuals to which the patient is assigned, wherein the treatment comprises one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.