Patent ID: 8338486

Claim:
A method of treating a patient with a neurological condition selected from the group consisting of Alzheimer's disease, dementia, Parkinson's disease, and neuropathic pain, comprising orally administering to a human subject in need thereof: (a) 22.5 mg to 30 mg memantine or a pharmaceutically acceptable salt thereof provided in a sustained release dosage form, wherein said sustained release memantine provides a change in mean plasma concentration of memantine as a function of time (dC/dT) that is: (1) less than about 50% of the dC/dT provided by the same quantity of an immediate release form of memantine, determined in a time period between 0-Tmax of the immediate release form of memantine; and (2) 2.1 ng/ml/hr or less, determined in a time period of 0 to 4 hours; wherein dC/dT is measured in a single dose human PK study; and (b) a therapeutically effective amount of immediate release donepezil.