Patent ID: 7160902

Claim:
A compound of formula Ia or Ib: wherein: R 1 is H or OH; R a is alkyl; R 2 is alkyl, aryl, or aralkyl; R 3 is alkyl, or R 2 and R 3 taken together with the atoms through which they are connected form a 4- to 8-membered heterocyclic ring; R 4 is H, alkyl, cycloalkyl, alkylcycloalkyl, aryl, aralkyl, heteroaryl, or heteroarylalkyl; Z is —(CH 2 ) o —NR 5 R 6 or —(CH 2 ) o —C(═O)NR 7 R 8 ; R 5 is H, alkyl, or aryl; R 6 is aryl, alkaryl, —CO(NH) p R 9 , or —SO 2 R 9 , provided that at least one of R 5 and R 6 is other than aryl; R 7 is H or alkyl; R 8 is alkyl, aryl, aralkyl, alkaryl, heteroaryl, heteroarylalkyl, cycloalkyl or cycloalkylalkyl; R 9 is alkyl, cycloalkyl, alkylcycloalkyl, aryl, aralkyl, heteroaryl, or heteroarylalkyl; m is the integer 1, 2, or 3; n is the integer 1, 2, or 3; o is the integer 0, 1, 2, or 3; p is the integer 0 or 1; and the quantity (m+n) is an integer in the range of 2 to 5; or a stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate, N-oxide or isomorphic crystalline form thereof.