Patent ID: 8685999

Claim:
A compound of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein: x is 0, 1, or 2; y is 0, 1, or 2; n is 1, 2, 3, 4, 5 or 6; R 1 , R 2 are each independently selected from hydrogen, halogen, C 1-6 alkyl, C 3-6 cycloalkyl, aryl, heteroaryl, NR a R b , S(O) x R a , C(O) y R a , and OR a , wherein said alkyl, cycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents R 7 ; R 3 is selected from hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, aryl, and heteroaryl, wherein said alkyl, cycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents R 7 ; R 4 is hydrogen or the two R 4 groups are (CH 2 ) n and together with the carbon atom to which they are attached form a 3 to 6 membered ring; R 5 , R 6 are each independently selected from hydrogen, halogen, C 1-6 alkyl, C 3-6 cycloalkyl, aryl, heteroaryl, NR a R b , S(O) x R a , and OR a , wherein said alkyl, cycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents R 7 ; R a , R b are each independently selected from hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 3-10 cycloalkyl, aryl, and heterocyclyl, wherein said alkyl, cycloalkyl, aryl and heterocyclyl are optionally substituted with one or more substituents R 7 ; R 7 is selected from hydroxy, aryl, halogen, â€”C 1-6 alkyl, C 1-6 alkoxy, hydrogen, S(O) x R a , and C 3-6 cycloalkyl.