Patent ID: 7026282

Claim:
A peptide comprising at least one peptide fragment of the general formula I: -X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 - (I) wherein X 1 , X 5 , X 6 , X 7 and X 9 are independently selected from amino acids and X 1 is the N-terminal amino acid of the fragment and X 9 is the C-terminal amino acid of the fragment; X 2 is selected from the group consisting of (a) amino acids of the general formula IIa wherein n is an integer in the range from 0 to 3; R 1 is selected from the group consisting of optionally substituted five-, six- and seven-membered non-aromatic rings; R 2 is selected from the group consisting of hydrogen and C 1-4 -alkyl; or, R 1 and R 2 together with the carbon atom to which they are bound form an optionally substituted cyclopentyl, cyclohexyl, cycloheptyl or decahydronaphthalenyl ring; and (b) N-substituted amino acids of the general formula IIb wherein n and R 1 are as defined above; X 3 and X 8 are each independently selected from the group consisting of amino acids having hydrophobic side chains and amino acids having hydrophobic N-substituents; X 4 is selected from the group consisting of (a) amino acids of the general formula IIIa wherein m is an integer in the range from 1 to 3, and Y is selected from the group consisting of OH, SH, NH 2 , CONH 2 , COOH and OPO 3 H; and (b) N-substituted amino acids of the general formula IIIb wherein m and Y are as defined above.