Patent ID: 7482345

Claim:
A compound represented by chemical formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is a single covalent bond is selected from the group consisting of: (1) O, (2) C 1 -C 4 alkylene, (3) S(O) n , (4) C 2 -C 6 alkenylene, (5) C(O), (6) CHR a , (7) (8) NR a , (9) arylene, and (10) heteroarylene, said arylene and heteroarylene are each optionally substituted with one or more substituents selected from R 5 and R 6 ; R a is selected from the group consisting of: (1) hydrogen, (2) C 1 -C 6 alkyl, (3) C 1 -C 6 alkoxy, (4) CONH 2 , (5) C(O) 2 R 4 , (6) C 0 -C 4 alkyl-OH, (7) O—C 1 -C 4 alkyl, (8) halogen, (9) aryl, (10) heteroaryl, (11) heterocycloalkyl, (12) COR 4 , (13) N(R 4 )(R 4 ), (14) O—R 4 , (15) N—C 1 -C 4 alkyl-O—R 4 ; said heteroaryl and aryl are each optionally substituted with one or more substituents selected from R 5 and R 6 ; R c and R d are each independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, and O—C 1 -C 6 alkyl, or R c and R d can join together with the carbon atom to which they are attached to form a ring selected from the group consisting of cycloalkyl and heterocycloalkyl; R 1 , R 2 and R 3 are each independently selected from the group consisting of: (1) hydrogen, (2) C 1 -C 6 alkoxy, (3) C 3 -C 6 cycloalkyl, (4) heteroaryl, (5) CN, (6) halogen, (7) C 1 -C 6 alkyl, (8) C 2 -C 6 alkene, (9) (10) C(O)—R 4 , (11) aryl, (12) OR 4 , (13) CON(R 4 ) 2 , (14) N(R 4 ) 2 , (15) C 1 -C 4 —OH, (16) heterocycloalkyl, (17) C(O) 2 —R 4 said aryl, heteroaryl, heterocycloalkyl, and cycloalkyl are each optionally substituted with one or more substituents selected from R 5 and R 6 ; R 4 is selected from the group consisting of: (1) aryl, (2) hydrogen, (3) halogen, (4) heteroaryl, (5) C 1 -C 6 alkyl-aryl, (6) C 3 -C 6 cycloalkyl, (7) C 1 -C 6 alkyl, (8) C 1 -C 6 alkyl-C 3 -C 6 cycloalkyl, (9) C 1 -C 6 alkyl-heteroaryl, (10) (11) C(O)—R 5 , (12) NH—C 1 -C 4 alkyl, (13) NH-aryl, (14) C 1 -C 4 alkyl-heterocycloalkyl, (15) heterocycloalkyl, (16) C 0 -C 4 alkyl-NH 2 , and (17) C 0 -C 4 alkyl-OH; said heteroaryl, aryl, heterocycloalkyl and cycloalkyl are each optionally substituted with one or more substituents selected from R 5 and R 6 ; R 5 and R 6 are each independently selected from: (1) hydrogen, (2) halogen, (3) C 1 -C 6 alkoxy, (4) aryl, (5) C 3 -C 6 cycloalkyl, (6) C 1 -C 6 alkyl, and (7) heteroaryl, said heteroaryl and aryl are each optionally substituted with one or more substituents selected from R 7 , or R 5 and R 6 , together with the nitrogen atom to which they are attached, can join to form a 5- to 7-membered heteroaryl or heterocycloalkyl R 7 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) aryl, (4) C 3 -C 6 cycloalkyl, (5) NH—C 1 -C 4 alkyl, (6) C 1 -C 6 alkyl, (7) heteroaryl, (8) C 1 -C 4 alkyl-heterocycloalkyl, (9) heterocycloalkyl, (10) C 0 -C 4 alkyl-NH 2 , and (11) C 0 -C 4 alkyl-OH; m is 0, 1, 2, or 3; and n is 0, 1, or 2.