Patent ID: 8808980

Claim:
Method for the diagnosis of an autoimmune disorder, comprising: providing a sample from a subject suspected of having the autoimmune disorder; contacting the sample with an open form transglutaminase using the open form transglutaminase or antigenically active fragments of the open form transglutaminase; determining if autoantibodies from the sample bind to the open form transglutaminase or antigenically active fragments of the open form transglutaminase, wherein binding of autoantibodies in the sample indicate that the subject has the autoimmune disorder; and wherein the autoimmune disorder is selected from the group consisting of Addisons's disease, autoimmune hepatitis, chronic inflammatory demyelinating polyneuropathy, Hashimoto thyroiditis, multiple sclerosis, polymyositis, ulcerative colitis, psoriasis, gluten sensitive disorders, celiac disease, dermatitis herpetiformis, diabetes mellitus type 1, dementia, epilepsy, headache with white matter abnormalities, neuropathy, gluten ataxia, idiopathic sporadic ataxia, ataxia with enteropathy, and stiff-man syndrome.