Patent ID: 7144901

Claim:
An oxadiazole compound of formula (I), wherein R is R 16 is CycA wherein CycA is mono-, bi- or tri-cyclic C3–15 carboring AA 1 is a single bond AA 2 is wherein R 48 is hydrogen, C1–4 alkyl, phenyl or C1–4 alkyl substituted with phenyl CycD is a C3–14 mono- or bi-cyclic carboring, R 7 and R 8 are the same or different to represent (i) hydrogen, (ii) C1–8 alkyl, or (iii) C1–8 alkyl substituted with 1–5 of groups selected from the following (1)˜(7): (1) —NR 61 R 62 , (2) —OR 63 , (3) —SR 64 , (4) —COR 65 , (5)-NR 66 CONR 61 R 62 , (6) CycA, (7)-NR 66 SO 2 R 61 , R 61 , R 62 , R 63 , R 64 and R 66 are the same or different to represent hydrogen, C1–4 alkyl, phenyl or C1–4 alkyl substituted with phenyl, R 65 is C1–4 alkyl, phenyl, —NR 61 R 62 , wherein all symbols are the same meanings as above, —OR 63 , wherein R 63 is the same meaning as above, or C1–4 alkyl substituted with phenyl, R 9 is hydrogen, C1–8 alkyl, phenyl or C1–8 alkyl substituted with phenyl R 10 is (i) C1–8 alkyl, (ii) C2–8 alkenyl, (iii) CycA, (iv) —COR 71 or (v) C1–8 alkyl substituted with 1–3 of group selected from CycA, —COR 71 , —NR 72 R 73 , —OR 74 , cyano or —P(O)(OR 78 ) 2 , wherein R 71 is (1) C1–4 alkyl, (2) C1–4 alkoxy, (3) CycA, (4) —O-CycA, (5) —NR 72 R 73 , (6) C1–4 alkyl substituted with CycA, (7) C1–4 alkoxy substituted with CycA, or (8) hydroxy, R 72 and R 73 are the same or different to represent hydrogen, C1–8 alkyl, CycA or C1–8 alkyl substituted with CycA, R 74 is (1) hydrogen, (2) C1–8 alkyl, (3) CycA, (4) C1–8 alkyl substituted with —SiR 75 R 76 R 77 , wherein R 75 , R 76 and R 77 are the same or different to represent C1–8 alkyl, phenyl or C1–8 alkyl substituted with phenyl, or (5) C1–8 alkyl substituted with CycA, R 78 is C1–8 alkyl, phenyl, or C1–8 alkyl substituted with phenyl; and, CycA's included in R 10 and R 16 are the same or different and CycA and CycD, independently, may be substituted with 1–5 of R 27 : R 27 is (1) C1–8 alkyl, (2) halogen, (3) —NR 11 R 12 , (4) —OR 3 , (5) a C5–10 mono- or bi-cyclic carboring, (6) nitro, (7) CF 3 , (8) cyano, (9) —SR 14 , (10) —COR 15 , (11) oxo, (12) —SO 2 R 15 , (13) —OCF 3 , or (14) C1–8 alkyl substituted with 1–5 of group selected from the following (a)˜(k): (a) halogen, (b) —NR 11 R 12 , (c) —OR 13 , (d) a C5–10 mono- or bi-cyclic carboring, (e) nitro, (f) CF 3 , (g) cyano, (h) —SR 14 , (i) —COR 15 , (j) —SO 2 R 15 , or (k) —OCF 3 , wherein R 11 and R 12 are the same or different to represent hydrogen, C1–4 alkyl, —COO-(C1–4 alkyl), phenyl or C1–4 alkyl substituted with phenyl, R 13 and R 14 are the same or different to represent hydrogen, C1–4 alkyl, phenyl or C1–4 alkyl substituted with phenyl, R 15 is C1–4 alkyl, phenyl, —NR 11 R 12 , wherein all symbols are the same meanings as above, —OR 13 wherein R 13 is the same meaning as above, or C1–4 alkyl substituted with phenyl or a non-toxic salt thereof.