Patent ID: 7229959

Claim:
A supplement delivery system comprising: (i) an effective amount of at least one supplement selected from the group consisting of a cytotoxin or cell proliferation inhibiting compound, an osteogenic compound, a cartilage inducing compound, an antibiotic, an anesthetic, an anticoagulant compound, an anti-inflammatory compound, a cardiovascular drug, and a steroid; and (ii) a biocompatible tissue sealant composition comprising fibrinogen in an amount which forms a fibrin matrix; wherein said fibrinogen will form a fibrin matrix when in the presence of thrombin and Ca ++ and water, and further wherein said supplement is delivered from said fibrin matrix into the external environment of use for a sustained period, and further wherein said effective amount of said supplement is greater than the amount which is soluble in said fibrin matrix, and further wherein said composition is substantially free of added protease inhibitors; and further wherein said sustained period is greater than the period obtained when the amount of said supplement is soluble in said fibrin matrix.