Patent ID: 8076093

Claim:
A method for diagnosing high-grade cervical disease in a patient, the method comprising: a) obtaining a cervical sample from the patient; b) contacting the sample with at least one monoclonal antibody that specifically binds to MCM2 and is selected from the group consisting of: (i) the monoclonal antibody produced by the hybridoma cell line 27C5.6, deposited with the ATCC as Patent Deposit No. PTA-6668; (ii) the monoclonal antibody produced by the hybridoma cell line 26H6.19, deposited with the ATCC as Patent Deposit No. PTA-6667; (iii) a monoclonal antibody that binds to the amino acid sequence set forth in SEQ ID NO:3; (iv) a monoclonal antibody that binds to the amino acid sequence of SEQ ID NO:14; and (v) an antigen binding fragment of a monoclonal antibody of (i)-(iv), wherein the fragment retains the capability of specifically binding to MCM2; and, c) detecting binding of the antibody to MCM2 in the cervical sample.