Patent ID: 7390635

Claim:
A method of humanizing a non-human antibody comprising replacing one or more framework amino acid residues in a variable region of said antibody with corresponding framework amino acids from a human variable region wherein non-human framework residues, as defined by the buried-residue-modification technique, are retained in their original form, wherein the antibody comprises both: (i) a light chain variable region, and (ii) a heavy chain variable region; wherein said variable regions are humanized in a region that is neither contained in a CDR, nor in contact with a CDR, nor in contact with an opposing variable region of Mc3 antibody, with the further proviso that the humanized Mc3 heavy chain variable region has the amino acid sequence shown in SEQ ID NO: 78 and the humanized Mc3 light chain variable region has the amino acid sequence shown in SEQ ID NO: 81.