Patent ID: 8420114

Claim:
A composition comprising one or more implantable drug depots useful for reducing or treating pain and/or inflammation in a patient in need of such treatment, the implantable drug depot comprising an alpha adrenergic agonist comprising clonidine hydrochloride and a beta adrenergic receptor agonist comprising ritodrine, salbutamol, or terbutaline, the drug depot being implantable at a site beneath the skin to reduce or treat pain and/or inflammation, wherein the one or more drug depots contain sufficient amounts to release about 0.01 to about 0.4 mg/kg/day of clonidine hydrochloride, and 160 to 500 mg/day of ritodrine, 20 to 500 mg/day of salbutamol, or 20 to 500 mg/day of terbutaline, over a period of 3 days to 6 months, and wherein the drug depot contains no water and comprises at least one biodegradable polymer comprising one or more of poly(lactide-co-glycolide) (PLGA), polylactide (PLA), polyglycolide (PGA), D-lactide, D,L-lactide, L-lactide, poly(D,L-lactide), poly(D,L-lactide-co-caprolactone) or poly(L-lactide-co-caprolactone) or a combination thereof and the polymer has an average molecular weight of from about 5,000 to about 500,000 daltons and the drug depot has a diameter of about 0.01 mm to about 2 mm wherein the drug depot further comprises methoxypolyethylene glycol (mPEG).