Patent ID: 8293892

Claim:
A method of treating a cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a composition, wherein said composition comprises a compound or a salt thereof and a pharmaceutically acceptable carrier or excipient, and wherein said compound is of formula I: wherein: X 1 , X 2 and X 3 , together with the two carbon atoms numbered “1” and “2”, form a ring selected from R x1 and R x2 are each independently selected from Q x -R x ; Q x is a bond, unsubstituted or substituted C 1 -C 6 alkyl linker, C(O), S(O) 2 , C(O)NR x′ or S(O) 2 NR x′ ; and R x and R x′ are each independently H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted C 6 -C 10 aryl-C 1 -C 6 alkyl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S; T is CH 2 or C(O); X is N or C-Q 4 -R 4 ; Y is H, NR 6 R 7 , OR 6 or SR 6 , unsubstituted or substituted C 1 -C 6 alkyl, substituted C 6 -C 10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S; Q 3 and Q 4 are each independently a bond, unsubstituted or substituted C 1 -C 6 alkyl linker, C(O), S(O) 2 , C(O)NR 5 or S(O) 2 NR 5 ; R 3 , R 4 and R 5 are each independently H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted C 6 -C 10 aryl-C 1 -C 6 alkyl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S; and R 6 and R 7 are each independently H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S.