Patent ID: 8715986

Claim:
A ligand-targeted multi-stereoisomer peptide polymer conjugate compound represented by a formula (Pol-L l -sP) n -Pol-L 2 -sP L , wherein: Pol is HPMA, HPMA copolymer, or HPMA derivatives, L 1 is a degradable linker with one end conjugated to a polymer branch and the other end conjugated to a stereoisomer peptide, comprising Gly, Phe, Leu, and Gly amino acids, sP is stereoisomer peptide of SEQ ID NO:10, 34, 47, 97, and 101, n is an integer from 2 to 5 representing different peptides, said peptides target the functional domains of proteins, said proteins are EGFR, HSP90, pl3K, neuropilin-2 (NPR-2), and αvβ3, L 2 is non-degradable linker with one end conjugated to a polymer branch and the other end conjugated to stereoisomer peptide-ligand comprising Gly, Gly amino acids, sP L is stereoisomer peptide-ligand comprising SEQ ID NO:25 or SEQ ID NO:112.