Patent ID: 8224414

Claim:
A sensor assembly for a transdermal analyte monitoring system comprising: a polyethylene glycol diacrylate macromer based hydrogel adapted to interface with permeabilized skin of a subject and to receive an analyte through the skin, wherein the polyethylene glycol diacrylate macromer has a molecular weight of 2000 to 8000 Da and is cross-linked in the presence of an enzyme to form a network of cross-linked macromer that entraps at least a portion of the enzyme; an electrode assembly comprising at least a first and second electrode, the first and second electrodes being arranged adjacent to each other on a surface of the a sensor body and positioned adjacent the hydrogel; wherein during operation the sensor assembly is positioned adjacent a permeabilized skin of the subject such that the enzyme reacts continuously with the analyte received through the subject's skin and an electrical signal which correlates to an analyte value is detected by the electrode assembly.