Patent ID: 7824866

Claim:
A method of identifying an agent that binds to a GPR72 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 2 and SEQ ID NO:4, wherein said GPR72 polypeptide is capable of binding to a polyunsaturated fatty acid (PUFA), said method comprising: (a) contacting said GPR72 polypeptide with said polyunsaturated fatty acid (PUFA) in the presence or absence of a candidate binding agent under conditions permitting binding of said PUFA to said GPR72 polypeptide; (b) permitting the PUFA to bind to the GPR72 polypeptide; and, (c) measuring binding of said GPR72 polypeptide to said PUFA, wherein a decrease in binding in the presence of said candidate binding agent, relative to binding in the absence of said candidate binding agent, identifies said candidate binding agent as an agent that binds to GPR72 polypeptide.