Patent ID: 7723322

Claim:
A compound having the formula: wherein R 1 is wherein R 2a , R 2b , R 3a and R 3b are each hydrogen; R 4a and R 5a and R 4b and R 5b are each hydrogen, or combined to form ═O; each R 6 is independently a member selected from the group consisting of H, optionally substituted C 1 -C 10 alkyl, C 1 -C 6 alkyl-CO 2 H, C 1 -C 6 alkyl-CONHR 7 , optionally substituted C 6 -C 12 aryl and L, wherein L is a linker selected from the group consisting of each R 7 is independently a member selected from the group consisting of H and C 1 -C 6 alkyl; or R 4a , R 5a and R 6 or R 4b , R 5b and R 6 are combined to form a 5-6 membered heteroaryl ring having from 1-3 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-3 R 8 ; or R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5a , R 5b and R 6 are combined to form a 11-14 membered heteroaryl ring having from 1-3 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-3 R 8 ; each R 8 is independently a member selected from the group consisting of H, optionally substituted C 1 -C 6 alkyl, optionally substituted C 5 -C 10 cycloalkyl, optionally substituted C 6 -C 12 aryl, optionally substituted C 5 -C 12 heteroaryl and L; wherein the substituted alkyl and substituted cycloalkyl groups are substituted with a member selected from the group consisting of —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, —CO 2 R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O) 2 R′, —NH—C(NH 2 )═NH, —NR′C(NH 2 )═NH, —NH—C(NH 2 )═NR′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR′R″, —CN and —NO 2 , wherein R′, R″and R′″ are each independently selected from the group consisting of hydrogen, unsubstituted (C 1 -C 8 )alkyl and heteroalkyl, unsubstituted aryl, unsubstituted alkyl, alkoxy or thioalkoxy groups, or aryl-(C 1 -C 4 )alkyl groups; wherein the substituted aryl and substituted heteroaryl groups are substituted with a member selected from the group consisting of -halogen, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO 2 , —CO 2 R′, —CONR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″C(O) 2 R′, —NR′—C(O)NR″R′″, —NH—C(NH 2 )═NH, —NR′C(NH 2 )═NH, —NH—C(NH 2 )═NR′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR′R″, —N 3 , —CH(Ph) 2 , perfluoro(C 1 -C 4 )alkoxy, and perfluoro(C 1 -C 4 )alkyl, wherein R′, R″ and R′″ are independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl and heteroalkyl, unsubstituted aryl and heteroaryl, (unsubstituted aryl)-(C 1 -C 4 )alkyl, and (unsubstituted aryl)oxy-(C 1 -C 4 )alkyl; and pharmaceutically acceptable salts and isomers thereof.