Patent ID: 7727990

Claim:
A compound having the formula of structure I: or an enantiomer, stereoisomer or diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein J is a ring structure selected from the group consisting of substituted or unsubstituted aromatic carbocyclic rings, substituted or unsubstituted non-aromatic carbocyclic rings, substituted or unsubstituted aromatic fused carbobicyclic ring groups, two substituted or unsubstituted aromatic carbocyclic rings wherein the rings are joined by a bond, —CH 2 —, or —O—, and substituted or unsubstituted aromatic fused heterobicyclic ring groups, wherein in each instance the rings include 5 or 6 ring atoms; W is R 4 is O, CH 2 , provided that R 5 comprises N or O, C 6 H 5 , provided that R 5 comprises N or O, C(═O), C(═O)—O, or O—C(═O); R 5 is OH, CH 3 , provided that R 4 comprises O, NH—(CH 2 ) z where NH—(CH 2 ) z together with R 4 forms a ring, NH—(CH 2 ) y —CH 3 , N(—(CH 2 ) y —CH 3 ) 2 , N(—(CH 2 ) y —CH 3 )—C(═NH)—NH 2 , N(—(CH 2 ) y —CH 3 )—C(═N((CH 2 ) y —CH 3 ))—NH 2 , NH—C(═NH)—NH 2 , NH—C(═N((CH 2 ) y —CH 3 ))—NH 2 , N(—(CH 2 ) y —CH 3 )—C(═N((CH 2 ) y —CH 3 ))—NH(CH 2 ) y —CH 3 , NH—C(═N((CH 2 ) y —CH 3 ))—NH—(CH 2 ) y —CH 3 , N(—(CH 2 ) y —CH 3 )—C(═NH)—NH(CH 2 ) y —CH 3 , NH—C(═N((CH 2 ) y —CH 3 ))—N((CH 2 ) y —CH 3 ) 2 , N(—(CH 2 ) y —CH 3 )—C(═NH)—N((CH 2 ) y —CH 3 ) 2 , O—(CH 2 ) y —CH 3 , SO 2 —NH 2 , SO 2 —NH—(CH 2 ) y —CH 3 , SO 2 —N(—(CH 2 ) y —CH 3 ) 2 or SO 2 —(CH 2 ) y —CH 3 , wherein any NH or NH 2 in the foregoing may be substituted by N-Prg or NH-Prg, respectively, where each Prg is independently an amine protecting group; Q is an aromatic carbocyclic ring selected from the group consisting of phenyl, substituted phenyl, naphthyl and substituted naphthyl; L 1 is a bond or a linker unit consisting of from one to eight backbone atoms selected from the group consisting of carbon, sulfur, oxygen or nitrogen; L 2 is a bond or —(CH 2 ) z —; L 3 is a bond or a linker unit consisting of from one to nine backbone atoms selected from the group consisting of carbon, sulfur, oxygen or nitrogen; R 1a , R 1b , R 2a and R 2b are selected such that: one of R 2a and R 2b are and the remaining of R 2a and R 2b is hydrogen and R 1a and R 1b are each hydrogen, R 1a and R 1b together form ═O, or one of R 1a and R 1b is a C 1 to C 6 aliphatic linear or branched chain and the remaining of R 1a and R 2b is hydrogen, or R 2a and R 2b are each hydrogen and one of R 1a and R 1b are and the remaining of R 1a and R 1b is hydrogen; X is CH 2 , C═O or C═S; t is an index value from 0 to 5; z is an index value from 1 to 6; and each y is independently an index value from 0 to 5; wherein the carbon atom marked with an asterisk can have any stereochemical configuration.