Patent ID: 7875295

Claim:
A process for the production of nano-sized particles of a drug compound, the process comprising the steps of: (a) providing a solution of said drug compound in a first liquid; (b) providing a second liquid in which said drug compound is insoluble, or substantially insoluble; (c) providing a molecular packing configured to rotate and induce a region of high rotational shear within a mixing zone; wherein said molecular packing is a substantially cylindrical shaped molecular packing formed from at least one mesh layer; (d) combining said first liquids and said second liquid directly onto the molecular packing to impart high rotational shear to said liquids during said combining, and wherein the high rotational shear forms discrete droplets of the first liquid and second liquid leading to high surface area contact therebetween, said high surface area contact of said droplets of the first liquid and second liquid causing precipitation and formation of said particles of the drug compound having a uniform particle size distribution; (e) controlling the uniform particle size of the drug particles to a particle size distribution wherein the median particle size is less than 500 nm and the maximum particle size is less than 1000 nm and wherein the particles are in the nano-size range by controlling the speed of rotation of the molecular packing within said mixing zone; and (f) isolating said nano-sized particles of said drug compound.