Patent ID: 7799824

Claim:
A compound which is a quaternary ammonium salt, the cation having Formula (I) or pharmaceutically acceptable forms of said compound thereof, wherein A is carbonyl, thiocarbonyl or sulfonyl; X is a bond —or —CH═CH—; R 1 is selected from (1). aryl optionally substituted by one or more lower alkyl, —(CH 2 ) n —CF 3 , lower alkoxy, alkoxycarbonyl, cyano, halogen or phenyl optionally substituted by lower alkyl, —(CH 2 ) n —CF3, lower alkoxy, alkoxycarbonyl, cyano or halogen; or (2). C 5 -C 15 cycloalkyl optionally substituted by one or more lower alkyl, —(CH 2 ) n —CF 3 , lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen; n is 0, 1, 2, 3, or 4; Y is a bond or —CH 2 —; X 2 is —(CH 2 ) m — wherein m is 1 or 2; R 2 is —N + (R4R 5 )—ZR 3 ; Z is —(CH 2 ) p — wherein p is 0, 1 or 2; R 3 is selected from (1). aryl optionally substituted by one or more lower alkyl, —(CH 2 ) n —CF 3 , lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen; (2). C 5 -C 15 cycloalkyl optionally substituted with one or more lower alkyl, —(CH 2 ) n —CF 3 , lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen; or (3). heterocyclyl optionally substituted with one or more lower alkyl, —(CH 2 ) n —CF 3 , lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen; wherein, when heterocyclyl is attached via a carbon atom ring member and a heteroatom ring member is adjacent to said carbon atom, then p is 1 or 2; R 4 and R 5 are each individually lower alkyl or lower alkenyl; or alternatively, R 4 and R 5 combine with the nitrogen atom of Formula (I) to form a heterocyclyl ring of 5 to 9 total ring atoms optionally containing one of an oxygen or sulfur ring atom, wherein the heterocyclyl ring nitrogen atom is substituted with one of lower alkyl or lower alkenyl to form a quaternary salt, and wherein —ZR 3 is absent and the heterocyclyl ring is optionally substituted with aryl optionally substituted with one or more lower alkyl, —(CH 2 ) n —CF 3 , lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen, said heterocyclyl for ring R 3 being tetrahydropyran, tetrahydrofuran, tetrahydrothiophene, tetrahydrothiopyran, pyrrolidine, morpholine, thiomorpholine, piperidine, thiophene or piperazine.