Patent ID: 8003406

Claim:
A method of aiding a determination of whether a subject has a susceptibility for development of Attention Deficit Hyperactivity Disorder (ADHD), the method comprising a) obtaining a sample from the subject, b) analyzing the sample for an ADHD susceptibility haplotype of latrophilin 3 receptor gene (LPHN3) by detecting nucleic acid in the sample with a sequence comprising at least one genetic marker selected from the group consisting of the rs7678046, rs 1901223, rs6813183, and rs 1355368 polymorphisms associated with the ADHD susceptibility haplotype of LPHN3 receptor, wherein rs7678046 refers to (i) an adenosine at nucleotide position 5 in SEQ ID NO: 1 within the subject's LPHN3 locus or (ii) a thymine on the complementary strand at the position complementary to the adenosine at position 5, wherein rs1901223 refers to (i) a guanine at nucleotide position 8 in SEQ ID NO:I within the subject's LPHN3 locus or (ii) a cytosine on the complementary strand at the position that is complementary to the guanine at position 8, wherein rs6813183 refers to (i) a cytosine at nucleotide position 17 in SEQ ID NO: 1 within the subject's LPHN3 locus or (ii) a guanine on the complementary strand at the position that is complementary to the cytosine at position 17, and wherein rs1355368 refers to (i) a guanine at nucleotide position 18 in SEQ ID NO:I within the subject's LPHN3 locus or (ii) a cytosine on the complementary strand at the position that is complementary to the guanine at position 18; and c) determining if the subject has a susceptibility to develop ADHD, whereby the presence of the haplotype is indicative of susceptibility to develop ADHD.