Patent ID: 8314087

Claim:
A compound of the following Formula I an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof wherein n is an integer from 0 to 3; L is C 1-6 alkylene, which may be optionally independently substituted with one or more halo; M is —O—, —NR 6 —, —C(═O)NR 6 —, or —NR 6 (C═O)—; R 1 is (1) —CN, —NR 6 —(C═O)R 7 , —NR 6 —(C═O)OR 7 , —NR 6 —(C═O)NR 8 R 9 , —(C═O)R 7 , —S(O) v R 7 , —SO 2 NR 8 R 9 , or —OR 7 , (2) cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, C 2-6 alkenyl, or C 2-6 alkynyl any of which may be optionally independently substituted with one or more R 10 as allowed by valence; R 2 is quinolinyl which may be optionally independently substituted with one or more as allowed by valence; R 3 is an optional substituent independently selected at each occurrence from halo, cyano, alkyl, alkenyl, alkynyl, —(C═O) 0-1 OR 7 , —(C═O) 0-1 NR 8 R 9 , —S(O) v R 7 , —SO 2 NR 8 R 9 , —C═OR 7 , —NR 8 C═OR 7 , —NR 6 —C═O—NR 8 R 9 and —NR 8 SO 2 R 7 ; R 6 at each occurrence is independently (1) H, or (2) alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl, any of which may be optionally independently substituted with one or more R 10 as allowed by valence; R 7 at each occurrence is independently (1) H, or (2) alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl any of which may be optionally independently substituted with one or more R 10 as allowed by valence; R 8 and R 9 at each occurrence are independently (1) H, or (2) alkyl, cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylalkyl, heteroalkylalkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl any of which may be optionally independently substituted with one or more R 10 as allowed by valence; or R 8 and R 9 together with the nitrogen atom to which they are attached may combine to form a heterocyclyl ring; and R 10 is one or more optional substituent independently selected at each occurrence as allowed by valence from halo, oxo, cyano, alkyl, haloalkyl, cycloalkyl, heterocyclyl, heteroaryl, aryl, heterocyclylalkyl, heteroarylalkyl, arylalkyl, —(CR 4 R 5 ) 0-3 OR 7 , —(CR 4 R 5 ) 0-3 NR 8 R 9 , —(CR 4 R 5 ) 0-3 N(R 6 )C═OR 7 , —(CR 4 R 5 ) 0-3 N(R 6 )(C═O)OR 7 , —(CR 4 R 5 ) 0-3 C═ONR 8 R 9 , —(CR 4 R 5 ) 0-3 O(C═O)NR 8 R 9 , —(CR 4 R 5 ) 0-3 C═OR 7 , —(CR 4 R 5 ) 0-3 N(R 6 )C═ONR 8 R 9 , —(CR 4 R 5 ) 0-3 S(O) v R 7 , —(CR 4 R 5 ) 0-3 SO 2 NR 8 R 9 or —(CR 4 R 5 ) 0-3 NR 6 SO 2 R 7 .