Patent ID: 7851637

Claim:
A compound of formula 1: or a pharmaceutically acceptable salt thereof, wherein Y is —C(O)—; X is —N(R 11 )—; X′ represents independently for each occurrence O, N(R 10 ), or S; m is 1; n represents 1; R 1 has the formula 1b: wherein R 16 represents independently for each occurrence H, alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, halide, hydroxyl, alkoxyl, aryloxy, acyloxy, amino, alkylamino, arylamino, acylamino, aralkylamino, nitro, acylthio, carboxamide, carboxyl, nitrile, —COR 10 , —CO 2 R 10 , —N(R 10 )CO 2 R 10 , —OC(O)N(R 10 ) 2 , —N(R 10 )SO 2 R 10 , or —N(R 10 )C(X′)N(R 10 ) 2 ; wherein any two instances of R 16 may be connected by a covalent bond to form a ring; Ar 2 represents independently for each occurrence monocyclic or bicyclic aryl with 6-14 ring atoms; X 1 represents a bond; X 2 represents independently for each occurrence halide, hydroxyl, alkoxyl, aryloxy, acyloxy, amino, alkylamino, arylamino, acylamino, aralkylamino, nitro, acylthio, carboxamide, carboxyl, nitrile, —COR 10 , —CO 2 R 10 , —N(R 10 )CO 2 R 10 , —OC(O)N(R 10 ) 2 , —N(R 10 )SO 2 R 10 , —N(R 10 )C(X′)N(R 10 ) 2 , or —CH 2 O-heterocyclyl; and q represents independently for each occurrence 1, 2, 3, 4, or 5; R 2 and R 7 are independently hydroxyl, alkoxyl, amino, alkylamino, or acylamino; R 3 , R 4 , R 5 and R 6 represent independently for each occurrence H or alkyl; R 8 is H, a branched or unbranched alkyl or alkenyl, cycloalkyl, heterocycloalkyl, bicycloalkyl, heterocycloalkyl substituted with an aralkyl group, or has the formula 1c: wherein p is 0, 1, 2, 3, 4, 5, or 6; and R 17 is aryl, cycloalkyl, cycloalkenyl, heterocyclyl, alkoxyl, heteroaryl, —OR 18 , —SR 18 , —N(R 18 ) 2 , —N(R 10 )CO 2 -alkyl, —CO 2 R 10 , —C(O)N(R 10 )aryl, or a polycyclic ring containing 8-14 carbon atoms; wherein R 18 is independently for each occurrence H, alkyl, aryl, aralkyl, acyl, -A l -A 2 -A 3 , or —CR 9 ═CR 9 (C(R 9 ) 2 ) n CR 9 ═C(R 9 ) 2 ; or two R 18 taken together form a ring; R 9 represents independently for each occurrence H or alkyl; R 10 and R 11 represent independently for each occurrence H, alkyl, aryl, cycloalkyl, aralkyl, heteroaryl, or heteroaralkyl; R 19 represents independently for each occurrence H, alkyl, aryl, cycloalkyl, aralkyl, heteroaryl, heteroaralkyl, or -A 1 A 2 -A 3 ; A l and A 3 represent independently for each occurrence alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; A 2 represents independently for each occurrence O, N(R 10 ), S, or a bond; and the stereochemical configuration at any stereocenter of a compound represented by 1 is R, S, or a mixture of these configurations.