Patent ID: 7612153

Claim:
A compound of formula I′: wherein: n is 10-2500; R 1 is —X(CH 2 CH 2 Y) m (CH 2 ) n′ R 3 , wherein: X is —O—, —S—, —C≡C—, or —CH 2 —; each Y is independently —O— or —S—; m is 0-10; n_′ is 0-10; and R 3 is —N 3 , —CN, a mono-protected amine, a di-protected amine, a protected aldehyde, a protected hydroxyl, a protected carboxylic acid, a protected thiol, a 9-30 membered crown ether, or an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a detectable moiety; R 2 is halogen, N 3 , CN, a mono-protected amine, a di-protected amine, a protected hydroxyl, a protected aldehyde, a protected thiol, —NHR 4 , —N(R 4 ) 2 , —SR 4 , —O(CH 2 CH 2 O) q (CH 2 ) r R 5 , —OC(O)R 4 , or —OS(O) 2 R 4 ; q and r are each independently 0-4; each R 4 is independently an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10-membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a detectable moiety, or: two R 4 on the same nitrogen atom are taken together with said nitrogen atom to form an optionally substituted 4-7 membered saturated, partially unsaturated, or aryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and R 5 is hydrogen, halogen, N 3 , CN, a mono-protected amine, a di-protected amine, a protected aldehyde, a protected hydroxyl, a protected carboxylic acid, a protected thiol, or an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a detectable moiety, provided that: (a) when either of R 1 or R 2 is (EtO) 2 CH—, then the other of R 1 or R 2 is not —S—S-pyridin-2-yl, —OBn, —OC(O)C(CH 3 )═CH 2 , or —OC(O)CH═CH—CH═CH-Ph; (b) when either of R 1 or R 2 is —OBn, the other is not —OC(O)Cl; (c) R 1 and R 2 are not simultaneously —OC(O)CH═CH 2 ; (d) when either of R 1 or R 2 is —CN, then the other is not -phthalimido; and (e) when either of R 1 or R 2 is acetyl, then the other is not —CN or -phthalimido.