Patent ID: 8058258

Claim:
An epigenetic method of inducing apoptosis in a tumour cell by inhibition of histone methylation, said method comprising administering to said tumour cell a compound of the general formula (I) wherein in formula (I) A is C or N, R 1 , R 4 and R 5 are independently selected from the group consisting of H and aliphatic, cycloaliphatic, aromatic, arylaliphatic, and arylcycloaliphatic hydrocarbyl groups, comprising 0-3 heteroatoms selected from the group N, O, S, and Si, wherein R 4 and R 5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge, R 2 is selected from the group consisting of H and halogen, and R 3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms selected from the group N, O, S, Si, and halogen.