Patent ID: 8492398

Claim:
A compound of formula I and pharmaceutically acceptable salts and solvates thereof: wherein A is hydrogen, carboxyl, or A is a heterocyle having at least one heteroatom, X, of formula X is selected from N, O and S; B is a carbocycle or a heterocycle; at least one of D, E, G, and J, is nitrogen and the rest are carbon; p is 0 or 1; R 1 , R 2 , R 15 and R 16 are independently selected from i) hydrogen; ii) C 1 -C 4 alkyl, optionally substituted with a hydroxy, —SH, —NH 2 or —CO 2 H; iii) trifluoromethyl; iv) 2,2,2-trifluoroethyl; and v) —CO 2 H; R 3 , R 4 and R 5 are independently selected from hydrogen, F, OH, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, —OC 1 -C 4 alkyl,)-, (C 0 -C 6 alkyl) 2 NC(O)—, —(C 0 -C 6 alkyl)C(O)NH(C 0 -C 6 alkyl), —(C 0 -C 6 alkyl)C(O)O(C 0 -C 6 alkyl), —(C 0 -C 6 alkyl)aryl, —(C 0 -C 6 alkyl)C(O)aryl, —(C 0 -C 6 alkyl)C(O)heteroaryl, and —(C 0 -C 6 alkyl)heteroaryl, where aryl, heteroaryl and are each optionally substituted with one to three groups independently selected from halo, C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl) and cyano; R 3 and R 4 attached to the same carbon atom together form an oxo group or complete a C 3 -C 6 cycloalkyl ring, or R 3 and R 4 attached to adjacent carbon atoms together complete a C 3 -C 6 cycloalkyl ring, or R 3 and R 4 attached to nonadjacent carbon atoms together represent C 1 -C 2 alkylene; R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 are independently selected from hydrogen, halo, C 1 -C 6 alkyl optionally substituted with one to five fluorine, NH 2 , N(C 1 -C 6 alkyl) 2 , NO 2 , CN, N 3 , —OH, —O(C 1 -C 6 alkyl) optionally substituted with one to five fluorine, C 3 -C 10 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, —O-aryl, aryl-S(O) 0-2 —, (C 0 -C 6 alkyl)S(O) 0-2 (C 0 -C 6 alkylene)-, (C 0 -C 6 alkyl)C(O)NH—, H 2 N—C(NH)—, (C 0 -C 6 alkyl)C(O)—, (C 0 -C 6 alkyl)OC(O)(C 0 -C 6 alkylene)-, (C 0 -C 6 alkyl)O(C 1 -C 6 alkylene)-, (C 0 -C 6 alkyl)C(O) 1-2 (C 0 -C 6 alkylene)-, (C 0 -C 6 alkyl) 2 NC(O)—, (C 0 -C 6 alkyl)OC(O)NH—, aryl, aralkyl, heteroaryl, and heteroaralkyl, where aryl, aralkyl, heteroaryl and heteroaralkyl are each optionally substituted with one to three groups, R 17 , R 18 and R 19 , independently selected from halo, C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl) and cyano; wherein any two of R 12 , R 13 , R 14 , R 17 , R 18 and R 19 together with the atoms of the ring system, B, form a 5 to 8-membered ring.