Patent ID: 8703129

Claim:
An isolated binding moiety which specifically binds to an epitope comprising an extended Type I chain comprising Le b , wherein the binding moiety comprises: (a) a heavy chain variable region (V H ) that includes: (i) a V H CDR1 sequence: Gly-Asp-Ser-Val-Ser-Ser-X 1 -X 2 -Val-Ala (SEQ ID NO:42), wherein X 1 is selected from the group consisting of Asn and Lys, and X 2 is selected from the group consisting of Thr and Ser; (ii) a V H CDR2 sequence: Thr-Tyr-Tyr-Arg-Ser-Lys-Trp-Tyr-Asn (SEQ ID NO:32); and (iii) a V H CDR3 sequence: Ala-Arg-Asn-Phe-Asp-X 3 (SEQ ID NO:43), wherein X 3 is selected from the group consisting of Ser and Tyr; and (b) a light chain variable region (V L ) that includes: (i) a V L CDR1 sequence: Thr-Gly-Ala-Val-Thr-Thr-X 4 -Asn-Tyr (SEQ ID NO:44), wherein X 4 is Asp; (ii) a V L CDR2 sequence: Ala-Thr-Ser (SEQ ID NO:36); and (iii) a V L CDR3 sequence: Ala-Leu-Trp-Tyr-Asn-Thr-His-Phe-Val (SEQ ID NO:37); wherein the binding moiety is an antibody or an antigen-binding fragment thereof.