Patent ID: 7429449

Claim:
A process for identifying inhibitors of a human potassium channel, a) providing a mutated S. cerevisiae cell which does not express the three endogenous potassium channels TRK1, TRK2 and TOK1 and which is not complemented by an expressed HERG1; b) treating said mutated cell with a mutated Kv1.5 human potassium channel wherein said human potassium channel is expressed heterologously in this mutated S. cerevisiae cell; c) incubating the S. cerevisiae cell expressing the human potassium channel together with a substance to be tested; and d) determining the effect of the substance to be tested on the human potassium channel, wherein a decrease in the transport of potassium across the human potassium channel indicates that the substance is an inhibitor if the human potassium channel.