Patent ID: 7622612

Claim:
Colchicine derivatives represented by the formula (I) or pharmaceutically acceptable salts thereof: wherein: when R 1 is N(R 5 )C(X 1 )—A, R 2 is hydrogen, X 2 R 6 , or X 2 (O)n 1 R 6 ; R 3 and R 4 are independently hydrogen, a methyl group, or a lower straight chain or branched alkyl, wherein R 5 and R 6 are independently hydrogen, or a lower straight chain or branched alkyl; X, X 1 , and X 2 are independently O or S; n 1 is an integer of 1 or 2; and A is selected from the group represented by the following formula: wherein R 7 is a phenyl, a C 1 to C 3 straight chain or branched alkyl, a C 1 to C 3 straight chain or branched alkoxy, halogen selected from F, Cl, Br or I, a nitro, or a cyano group; R 8 is hydrogen, —ONO 2 , halogen selected from F, Cl, Br, or I; n 2 is an integer from 1 to 3.