Patent ID: 8642729

Claim:
A peptide derivative of formula (I): ζ-AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -OH (I), wherein: ζ is hydrogen atom, tyrosine, Y-[linker]- or a Zn chelating group selected from the group consisting of cysteine, C-[linker]-, N-acetyl-cysteine, N-mercaptoacetyl (HS—CH 2 —CO—), hydroxamic acid (HO—NH—CO—) and an optionally substituted hydroxyquinoline, AA 1 is Q or Glp, AA 2 is K, R or H, AA 3 is Y, G, F or F(X), AA 4 is P, S or S(OAlk), AA 5 is K or R, C-[linker]- meaning Cys-[NH—(CH 2 ) n —CO]—, wherein n is an integer between 1 and 20, Y-[linker]- meaning Tyr-[NH—(CH 2 ) n —CO]—, wherein n′ is an integer between 1 and 20, F(X) meaning a phenylalanine, the phenyl group of which is substituted by one or more halogen atoms, S(OAlk) meaning a serine, the hydroxyl group of which is substituted by a linear or branched alkyl group having from 1 to 20 carbon atoms, said AA 1 , AA 2 , AA 3 , AA 4 , and AA 5 may be independently either in the L-configuration or D-configuration, and any one of AA 1 , AA 2 , AA 3 , AA 4 , and AA 5 may be optionally a β aminoacid, an aza-aminoacid or a β-aza-aminoacid; wherein if the peptide derivative comprises a cysteine, said peptide derivative is optionally a dimer, with the proviso that the peptide is not QRFSR (SEQ ID NO: 1), QRGPR (SEQ ID NO: 9), YQRFSR (SEQ ID NO: 3) or GlpRFSR (SEQ ID NO: 17).