Patent ID: 7767810

Claim:
A macrocyclic module of the formula: wherein: J is 2-23; Q 1 are synthons each independently selected from (a) phenyl synthons coupled to linkages L at 1,2-phenyl positions, (b) phenyl synthons coupled to linkages L at 1,3-phenyl positions, and (c) cyclohexane synthons coupled to linkages L at 1,2-cyclohexyl positions; wherein each ring position of each Q 1 not coupled to a linkage L is independently substituted with hydrogen or a functional group; Q 2 is a cyclohexane synthon coupled to linkages L at 1,2-cyclohexyl positions; wherein each ring position of Q 2 not coupled to an L is independently substituted with hydrogen or a functional group, and wherein at least one of the ring positions of Q 1 or Q 2 that is not coupled to an L is substituted with a lipophilic moiety independently selected from -(8C-28C)alkyl, —O(8C-28C)alkyl, —NH(8C-28C)alkyl, —OC(O)-(8C-28C)alkyl, —C(O)O-(8C-28C)alkyl, —NHC(O)-(8C-28C)alkyl, C(O)NH-(8C-28C)alkyl, —CH═CH-(8C-28C)alkyl and —C≡C-(8C-28C)alkyl, each of which groups optionally being interrupted within the (8C-28C)alkyl portion of the group by one or more —S—, double bond, triple bond or —SiR′R″— groups, and optionally being substituted within the (8C-28C)alkyl portion of the group with one or more fluorine atoms, and wherein R′ and R″ are independently selected from (1C-18C)alkyl; wherein each functional group is independently selected from —C(O)F, —C(O)O-4-nitrophenyl, —C(O)O-pentafluorophenyl, —C(O)O-N-hydroxysuccinimide, a lipophilic group, —OH, —C(O)OH, —C(O)H, —C(O)OCH 3 , —C(O)Cl, —NRR, —NRRR + A − , -MgX, -Li, -OLi, —OK, —ONa, —SH, —C(O)(CH 2 ) 2 C(O)OCH 3 , —NH-alkyl-C(O)CH 2 CH(NH 2 )CO 2 -alkyl, —CH═CH 2 , —CH═CHR, —CH═CR 2 , 4-vinylaryl, —C(O)CH═CH 2 , —NHC(O)CH═CH 2 , — wherein R are each independently selected from hydrogen and (1C-6C)alkyl; X is selected from Cl, Br, and I; A − is an anion; r is 1-50; and s is 1-4; and L are linkages between the synthons each independently selected from —NHC(O)—, —CH═N—, and —CH 2 NH— wherein linkages L are each independently configured in either of two possible configurations, forward and reverse, with respect to the synthons it couples together, if the two configurations are different structures.