Patent ID: 8293915

Claim:
A compound of Formula (1): or pharmaceutically acceptable salts thereof; wherein B is Y is —SO 2 —, or —O—C(═O)—; J is OH, OCH 3 , NH—CH(phenyl) 2 , NH(CH 2 ) 1 —OR 6 , NH(CH 2 ) 1 —SO 2 —R 6 , NH(CR 2 ) 1 —R 6 or wherein R 6 is C 1-6 alkyl, or phenyl, pyridyl, cyclopropyl, cyclohexyl, benzothiazolyl, 2,3-dihydro-1H-indenyl, morpholinyl, imidazolyl, tetrahydropyranyl, piperidinyl, thiophenyl, 2,3-dihydrobenzo[b][1,4]-dioxinyl or benzothiophenyl, each of which is optionally substituted by C 1-6 alkyl, halo, hydroxyl, C 1-6 alkoxy, SO 2 NR 2 , CONR 8 R 9 , O(CR 2 ) 1 R 5 wherein R 5 is phenyl, or CONR(CR 2 ) 1 R 6 wherein R 6 is phenyl; R 1 is —(CH 2 ) m —NH 2 , —(CH 2 ) m —NHC(═NH)—NH 2 , or (CR 2 ) m —X wherein X is piperidinyl, C 3-7 cycloalkyl or phenyl; or R 1 is C 1-6 alkyl; R 2 is a substituent at any position on ring A and is —O—(CR 2 ) p —R 7 or —OC(O)—NR 8 R 9 ; R 3 is C 1-6 alkyl, cyclohexyl, or —(CR 2 ) 1 —R 7 ; R 4 is C 2-6 alkenyl or —CR═CR—R 6 wherein R 6 is C 1-6 alkyl or phenyl substituted by C 1-6 alkoxy; or R 4 is phenyl, piperidinyl or wherein ring E is cyclohexyl unsubstituted or substituted by NR 2 ; or ring E is piperidinyl; R 5 is thiazolyl; R 7 is a phenyl unsubstituted or substituted by halo; R 8 and R 9 together with N form a 6 membered heterocyclic ring; each R is H or C 1-6 alkyl; 1 is 0-4; m is 1-4; n is 1-2; and k, p and q are 1.