Patent ID: 7381224

Claim:
A bone implant composite comprising a collagen matrix and calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 μm and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 μm, a density range of 0.02-0.8 g/cm 3 , and a tensile strength range of 0.4-100 kg/cm 2 ; and the bone implant composite is prepared by dispersing collagen fibers and calcium-based mineral in an acidic or basic aqueous solution to form a suspension, freeze-drying the suspension to form a dry mixture, and contacting the dried mixture with a crosslinking agent to crosslink the collagen fibers.