Patent ID: 6924289

Claim:
A compound of the formula I, depicted below, wherein R 1 is a group of the formula G 1 , depicted below, wherein R 6 independently selected from hydrogen, (C 1 -C 8 ) alkyl, [(C 2 -C 4 )alkyl]aryl wherein the aryl moiety is phenyl or naphthyl, and wherein said aryl moiety may optionally be substituted with one or more substituents independently selected from chloro, fluoro, bromo, iodo, (C 1 -C 6 )alkyl, (C 1 -C 8 )alkoxy, trifluoromethyl, cyano and SO g (C 1 -C 5 )alkyl wherein g is zero, one or two; x is zero to eight; each R 13 is, independently, (C 1 -C 4 )alkyl; R 2 is hydrogen, (C 1 -C 4 )alkyl, phenyl or naphthyl, wherein said phenyl or naphthyl may optionally be sustituted with one or more substituents independently selected from chloro, fluoro, brom, iodo, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy, trifuoromethyl, cyano and SO g (C 1 -C 6 )alkyl wherein g is zero, one or two; R 3 is (CH 2 ) m B, wherein m is zero, one, two or three and B is hydrogen, phenyl or naphthyl and wherein each of the foregoing phenyl and naphthyl groups may optionally be substituted with one or more substituents independently selected from chloro, fluoro, bromo, iodo, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, trifluoromethyl, cyano hydroxy, COOH and SO g (C 1 -C 6 )alkyl wherein g is zero, one or two; Z is CR 4 R 5 , wherein R 4 and R 5 are independently selected from hydrogen, (C 1 -C 6 )alkyl and trifluoromethyl; or Z is a combination one CR 4 R 5 and a phenylene or naphthylene wherein two adjacent ring members of said phenylene or naphthylene are also members of ring A; X is hydrogen, chloro, fluoro, bromo, iodo, cyano, (C 1 -C 6 )alkyl, hydroxy, trifluoromethyl, (C 1 -C 6 )alkoxy, —SO g (C 1 -C 6 )alkyl wherein g is zero one or two, CO 2 R 10 or CONR 11 R 12 ; each of R 10 , R 11 and R 12 is selected, independently, from the radicals set forth in the definition of R 2 ; n is three; and the broken line indicates an optional double bond; with the proviso that when Z is a combination of one CR 4 R 5 and a phenylene or naphthylene wherein two adjacent ring members of said phenylene or naphtylene are also members of ring A then n is 1; or a pharmaceutically acceptable salt thereof.