Patent ID: 7626038

Claim:
A method for manufacturing R-(−)-sertaconazole mononitrate (V) which comprises: a) the reaction of R-(−)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol (VI): with an intermediate of general formula (III): wherein L is a leaving group, in the presence of phase-transfer catalyst in a medium constituted by an immiscible solvent in water and water, and in the presence of a base, followed by treatment with nitric acid and recrystallization of the solid formed from an appropriate solvent; b) the conversion of the solid formed in the preceding stage into R-(−)-sertaconazole mononitrate (V) by drying at a temperature between 80 and 90° C.; and c) the purification of R-(−)-sertaconazole mononitrate (V) obtained in the preceding stage.