Patent ID: 6891023

Claim:
A recombinant antibody recognizing IOR C2 antigen, the recombinant antibody being produced from murine monoclonal antibody IOR C5 produced by the hybridoma deposited with the European Collection of Cell Cultures under accession number 97061101, wherein said recombinant antibody comprises Complementary Determining Regions (CDRs) and framework regions (FRs) of the murine monoclonal IOR C5 and humanized constant regions in its light and heavy chains, and wherein the heavy and light chains comprise at least one framework region point mutation selected from the group consisting of: Heavy Chain: Position 10 ASP for GLY Position 17 SER for THR Position 43 ASN for LYS Position 44 LYS for GLY Light Chain: Position 15 ILE for LEU Position 45 LYS for ARG Position 63 THR for SER.