Patent ID: 8053431

Claim:
A compound of Formula IA or a pharmaceutically acceptable salt thereof: wherein: R 1 is —(CH 2 ) 2 —R 6 ; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, and —C(═O)R 13 ; the ring Rx is hydrogen or C 1-6 alkyl, and is substituted once with —OH; R 6 is selected from the group consisting of cyano, aryl, hetaryl, -oxoC 1 -C 6 alkyl-S(═O) n R 13 , —C(═O)R 13 , —S(═O) n R 13 , —S(═O) n NR 18 R 19 , —N(R 18 )S(═O) n R 13 , —N(R 23 )C(═O)NR 18 R 19 , —C(═NR 15 )NR 15 , —N(R 18 )C(═O)R 13 , —N(R 18 )C(═O)—C 3 -C 6 cycloalkyl, and —N(R 18 )C(═O)—(3-6 membered hetcycloalkyl), wherein the cycloalky l, hetcycloalkyl, aryl, and hetaryl groups are substituted with 0-3 R 16 ; R 13 is selected from the group consisting of —OH, C 1 -C 4 alkyl, C 1 -C 4 alkyloxy, C 1 -C 4 alkyloxyC 1 -C 4 alkylene, aryl, hetaryl, aryloxy, hetaryloxy, and NR 18 R 19 ; R 15 and R 16 are independently selected from the group consisting of H, C 1 -C 4 alkyl, 3-6-membered cycloalkyl, halo, OH, cyano, —C(═O)R 13 , —S(═O ) n R 13 , —S(═O ) n NR 18 R 19 , —N(R 18 )S(═O) n R 13 , aryl, and hetaryl, wherein the alkyl and cycloalkyl groups are substituted with 0-1 R 20 ; R 18 and R 19 are independently selected from the group consisting of H, C 1 -C 4 alkyl, C 1 -C 4 alkyloxy, aryl, hetaryl, arylC 1 -C 4 alkylene, and hetarylC 1 -C 4 alkylene, wherein the alkyl, alkylene, aryl, and hetaryl groups are independently substituted with 0-1 R 20 ; alternatively, R 18 and R 19 , together with the nitrogen atom to which they are attached, form a saturated or partially saturated monocyclic, bicyclic, or tricyclic ring consisting of the shown nitrogen, 4-5 carbon atoms, and 0-1 additional heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein this ring is substituted 0-1 times with substituents selected from the group consisting of C 1 -C 4 alkyl, aryl, hetaryl, arylC 1 -C 4 alkylene, hetarylC 1 -C 4 alkylene, hydroxy, and C 1 -C 4 alkyloxy; R 20 is selected from the group consisting of H, OH, oxo, halo, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkyloxy, NR 21 R 22 , trihalomethyl, and trihalomethyloxy; R 21 and R 22 are independently selected from the group consisting of H, C 1 -C 4 alkyl, and arylC 1 -C 4 alkyl; R 23 is selected from the group consisting of H and C 1 -C 6 alkyl; and n is 2.