Patent ID: 6992088

Claim:
A compound of formula I: wherein: one of R 1 and R 2 is nitro or NR a R b ; the other of R 1 and R 2 is hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, NR a R b , COOR c , or OR d ; and R 3 and R 4 are each independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, NR a R b , COOR c , or OR d , or R 3 and R 4 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy; or R 1 and R 2 are each independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, NR a R b , COOR c , or OR d , or R 1 and R 2 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy; one of R 3 and R 4 is nitro or NR a R b ; and the other of R 3 and R 4 is hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, NR a R b , COOR c , or OR d ; R 5 is (C 1 -C 6 )alkyl substituted with one or more (C 1 -C 6 )alkoxycarbonyl, cyano, halo, hydroxy, mercapto, oxo, carboxy, nitro, pyrrolidinyl, piperidinyl, imidazolidinyl, imidazolinyl, piperazinyl, morpholinyl, thiomorpholinyl, or —NR f R g groups, wherein R f and R g may be the same or different and are chosen from hydrogen, (C 1 -C 6 )alkyl, and (C 3 -C 6 )cycloalkyl; X is two hydrogens, ═O, ═S, or ═NR e ; the bond marked “a” is a single bond or a double bond; R a and R b are each independently hydrogen or (C 1 -C 6 )alkyl, or R a and R b together with the nitrogen to which they are attached form a pyrrolidino, piperidino or morpholino ring; each R c is hydrogen, (C 1 -C 6 )alkyl, aryl, or aryl(C 1 -C 6 )alkyl; each R d is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, aryl, or aryl(C 1 -C 6 )alkyl; and R e is hydrogen, (C 1 -C 6 )alkyl, aryl, or aryl(C 1 -C 6 )alkyl; or a pharmaceutically acceptable salt thereof.