Patent ID: 8357711

Claim:
A compound of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 5 is a member independently selected from H or a group selected from (C 1 -C 10 )alkyl, heteroalkyl, heterocycloalkyl, (C 3 -C 8 )cycloalkyl, heteroaryl, aryl(C 1 -C 2 )alkyl, aryloxy(C 1 -C 2 )alkyl, heteroaryloxy(C 1 -C 2 )alkyl and heteroaryl(C 1 -C 2 )alkyl, each optionally substituted at any suitable point with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, halo(C 1 -C 4 )alkoxy, amino, (C 1 -C 4 )alkylamino, di(C 1 -C 4 )alkylamino, trifluoromethylthio, (C 3 -C 8 )cycloalkyl or phenyl optionally substituted with halogen, cyano, hydroxy, methyl, methoxy, trifluoromethyl or trifluoromethoxy, R 6 is represented by a member selected from the group consisting of heteroaryl, aryl(C 1 -C 3 )alkyl, heteroaryl(C 1 -C 2 )alkyl, aryloxy(C 1 -C 2 )alkyl, heteroaryloxy(C 1 -C 2 )alkyl, arylamino(C 1 -C 2 )alkyl and heteroarylamino(C 1 -C 2 )alkyl, wherein each is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkoxy, hydroxy(C 1 -C 4 )alkoxy, halo(C 1 -C 4 )alkoxy, (C 3 -C 8 )cycloalkyl(C 1 -C 4 )alkoxy, amino, (C 1 -C 4 )alkylamino, di(C 1 -C 4 )alkylamino, trifluoromethylthio, (C 3 -C 8 )cycloalkyl, pyrazolyl, pyrazolylmethyl, pyrazolylethyl, phenyl, benzyl, phenethyl, pyridyl, pyridylmethyl, phenoxy, phenoxymethyl, pyridyloxy and pyridyloxymethyl, wherein each pyrazolyl, pyrazolylmethyl, pyrazolylethyl, phenyl, benzyl, phenethyl, pyridyl, pyridylmethyl, phenoxy, phenoxymethyl, pyridyloxy or pyridyloxymethyl is optionally substituted at any suitable point with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, methyl, methoxy, trifluoromethyl or trifluoromethoxy; Z is a 5-membered heteroaryl selected from the group consisting of 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, and 1,3-thiazol-5-yl in which said heteroaryl may be optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, halo(C 1 -C 4 )alkoxy, (C 3 -C 8 )cycloalkyl, amino, (C 1 -C 4 )alkylamino and di(C 1 -C 4 )alkylamino; and B is phenyl as depicted below: in which said phenyl is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, halo(C 1 -C 4 )alkoxy.