Patent ID: 8338455

Claim:
A compound of formula I or a salt thereof wherein X is CH; Y is (C 1 -C 6 )alkylene, or (C 1 -C 6 )alkenylene wherein substituents on the same carbon atom or on adjacent carbon atoms may optionally combine to form a C 3 to C 6 -membered cycloalkyl ring, or a C 5 -C 6 heterocyclyl ring; Z is p and p* are each independently absent or a bond; R 1 and R 2 together with the ring to which they are bonded combine to form quinoline, optionally independently substituted with one or more R 10 ; R 3 is H, NHR 7 , C(═O)NHR 7 , NHC(═O)NR 8 R 9 , or NHC(═S)NR 8 R 9 ; R 4 and R 4a are independently selected from H, and alkyl, or R 4 and R 4a combine to form ═O; R 5 is H, C(═O)NHR 7 , NHC(═O)NHR 7 or NHC(═O)R 7 ; R 6 is H, halo, C(═O)NHR 7 , NHC(═O)R 7 , or NHC(═O)NR 8 R 9 ; R 7 is independently at each occurrence a) H, or b) alkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkyl, alkyl, arylalkyl, alkoxyalkyl, heteroarylalkyl, cycloalklyalkyl, or 2,3-dihydroindole, any of which can be optionally substituted with one or more R 10 ; R 10 is halo, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkyl, cyano, nitro, —NR 8 R 9 , —C(═O)NR 8 R 9 , or NHC(═O)NR 8 R 9 ; R 8 and R 9 are independently H, alkyl, haloalkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkyl, any of which may be optionally independently substituted with one or more R 10 provided R 5 is not H, C(═O)NHR 7 , or NHC(═O)R 7 when Z is piperidinyl.