Patent ID: 7241804

Claim:
An apoptotic composition that induces apoptosis by binding to a Bcl-2 family member protein and preferentially inducing apoptosis in a cell that over-expresses the Bcl-2 family member protein, the composition having the following formula II, having an absolute configuration of [2R, 3R, 4S, 7S, 8R], and wherein R 1 is hydrogen, a C 1 –C 8 linear or branched alkane, hydroxyl, a C 1 –C 8 hydroxyalkane, amino, a C 1 –C 8 di- or tri-amine, a C 1 –C 8 amide, a C 1 –C 8 carboxylic acid, or a substituted alkyl group; R 2 is hydrogen, a C 1 –C 8 linear or branched alkane, hydroxyl, a C 1 –C 8 hydroxyalkane, amino, a C 1 –C 8 di- or tri-amine, a C 1 –C 8 amide, a C 1 –C 8 carboxylic acid, or a substituted alkyl group; R 3 is hydrogen, a C 1 –C 8 linear or branched alkane, hydroxyl, a C 1 –C 8 hydroxyalkane, amino, a C 1 –C 8 di- or tri-amine, a C 1 –C 8 amide, a C 1 –C 8 carboxylic acid, or a substituted alkyl group; R 4 is hydrogen, a C 1 –C 8 linear or branched alkane, a C 1 –C 8 hydroxyalkane, or a substituted alkyl group; R 5 is hydrogen, a C 1 –C 8 linear or branched alkane, hydroxyl, a C 1 –C 8 hydroxyalkane, amino, a C 3 –C 8 di- or tri-alkylamine, a C 1 –C 8 carboxylic acid, a C 2 –C 8 amide, or a substituted alkyl group; and R 6 is hydrogen, a C 1 –C 8 linear or branched alkane, hydroxyl, a C 1 –C 8 hydroxyalkane, amino, a C 1 –C 8 di- or tri-amine, a C 1 –C 8 amide, a C 1 –C 8 carboxylic acid, or a substituted alkyl group.