Patent ID: 8071568

Claim:
A compound of the structural formula I: or a pharmaceutically acceptable salt thereof; wherein B is wherein the asterisk (*) denotes the point of attachment to the rest of the compound; n is 0, 1, or 2, X is a bond or O; Ar is phenyl, naphthyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, quinolinyl, or isoquinolinyl, wherein Ar is optionally substituted with one to five substituents independently selected from the group consisting of halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, cyano, nitro, amino, carboxy, trifluoromethyl, trifluoromethoxy, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 alkylcarbonyl, C 1-4 alkylcarbonyloxy, and C 1-4 alkyloxycarbonyl; R 1 is hydrogen, methyl, or, fluoromethyl; R 2 is fluoro or OR 10 ; R 3 is selected from the group consisting or hydrogen, C 1-16 alkylcarbonyl, C 2-18 alkenylcarbonyl, C 1-10 alkyloxycarbonyl, C 3-6 cycloalkylcarbonyl, C 3-6 cycloalkyloxycarbonyl, and an amino acyl residue of structural formula: R 10 is selected from the group consisting of hydrogen, methyl, C 1-16 alkylcarbonyl, C 2-18 alkenylcarbonyl, C 1-10 alkyloxycarbonyl, C 3-6 cycloalkylcarbonyl, C 3-6 cycloalkyloxycarbonyl, and an amino acyl residue of structural formula: or R 3 and R 10 together with the oxygen atoms to which they are attached form a five-membered cyclic carbonate or an acetonide; R 4 is hydrogen, C 1-6 alkyl, phenyl, or benzyl; wherein alkyl is optionally substituted with one substituent selected from the group consisting of fluorine, hydroxy, methoxy, amino, carboxy, carbamoyl, guanidino, mercapto, methylthio, 1H-imidazolyl, and 1H-indol-3-yl; and wherein phenyl and benzyl are optionally substituted with one to two substituents independently selected from the group consisting of halogen, hydroxy, and methoxy; R 5 is hydrogen or C 1-3 alkyl; or R 4 and R 5 together with the carbon atom which they are attached form a 3- to 6-membered aliphatic spirocyclic ring system; R 6 is C 1-16 alkyl, C 2-20 alkenyl, (CH 2 ) n C 3-6 cycloalkyl, phenyl, benzyl, or adamantyl; wherein alkyl, alkenyl, cycloalkyl, and adamantyl are optionally substituted with one to three substituents independently selected from amino C 1-4 alkylamino, di-(C 1-4 alkyl)amino, halogen, hydroxy, carboxy, and C 1-4 alkoxy, and wherein phenyl and benzyl are optionally substituted with one to three substituents independently selected from halogen, hydroxy, cyano, C 1-4 alkoxy, trifluoromethyl; and trifluoromethoxy; R 7 is hydrogen, C 1-5 alkyl, or phenyl C 0-2 alkyl; R 8 is hydrogen, C 1-4 alkyl, C 1-4 acyl, benzoyl, C 1-4 alkyloxycarbonyl, phenyl C 0-2 alkyloxycarbonyl, C 1-4 alkylaminocarbonyl, phenyl C 0-2 alkylaminocarbonyl, C 1-4 alkylsulfonyl, or phenyl C 0-2 alkylsulfonyl; R 9 is hydrogen, alkylcarbonyl, or C 1-8 alkyloxycarbonyl; R 11 is hydrogen C 1-3 alkyl; or R 11 together with R 13 form a ring of formula: R 12 is hydrogen or C 1-3 alkyl; R 13 is hydrogen or C 1-3 alkyl; and R 14 is hydrogen or C 1-3 alkyl, or C 1-8 alkylcarbonyl.