Patent ID: 8420067

Claim:
A macromolecule comprising: (1) a dendrimer comprising: (i) a triamino, tetraamino or pentaamino core moiety having a first nitrogen atom for attachment to a first functional moiety and at least two further nitrogen atoms for attachment to lysine or lysine analogue building units; (ii) one or more layers of lysine or lysine analogue building units, wherein each building unit in a first of the layers is attached to the core moiety by an amide bond, through the at least two further nitrogen atoms of the core moiety, and any building units in subsequent layers are attached to a previous layer through an amide bond, wherein an outermost layer of the one or more lysine or lysine analogue building units has at least one surface amine for attachment to the one or more second functional moieties; (2) a first functional moiety attached to the core moiety through the first nitrogen atom; and (3) one or more second functional moieties attached to the surface amines of the outermost layer of lysine or lysine analogue building units; wherein the second functional moiety is a pharmacokinetic modifying agent selected from the group consisting of polyfluorocarbons, fatty acids, lipids, oligo- and poly-saccharides deoxycholic acids, polyethylene glycol (PEG), polypropyleneglycol (PPG), alkyl capped forms of PEG and PPG, and polyethyloxazoline motif, and the first functional moiety is not lysine or lysine analogue, and is an agent selected from the group consisting of pharmaceutically active agents and interacting agents.