Patent ID: 7238695

Claim:
A compound of the formula (I), the racemic-diastereomeric mixtures and optical isomers of said compound of formula (I) and pharmaceutically-acceptable salts thereof, wherein — represents an optional bond; R 1 is H; R 2 is H; R 3 is —CH 2 -indol-3-yl, —(CH 2 ) 4 —NH—CO—O-t-Bu or —(CH 2 ) 4 —NH 2 ; R 4 is H or —(CH 2 ) m —A 1 ; A 1 is —C(═Y)—N(X 1 X 2 ), —C(═Y)—X 2 , —C(═NH)—X 2 or X 2 ; Y is O or S; X 1 is H, (C 1 -C 12 )alkyl, —(CH 2 ) m —NH—(C 1 -C 6 )alkyl, —(CH 2 ) m —N-di-(C 1 -C 6 )alkyl or —(CH 2 ) m -aryl; X 2 is —(CH 2 ) m —Y 1 —X 3 or optionally substituted (C 1 -C 12 )alkyl; Y 1 is O, S, NH, C═O, (C 2 -C 12 )alkenyl having one or more double bonds, —NH—CO—, —CO—NH—, —NH—CO—O—(CH 2 ) m —, —C≡C—, SO 2 or a bond; X 3 is H, an optionally substituted moiety selected from the group consisting of (C 1 -C 12 )alkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 12 )alkoxy, aryloxy, (C 1 -C 12 )alkylamino, N,N-di-(C 1 -C 12 )alkylamino, —CH-di-(C 1 -C 12 )alkoxy, pyrrolidinyl, pyridinyl, thiophene, imidazolyl, piperidinyl, piperazinyl, benzothiazolyl, furanyl, indolyl, morpholino, benzo[b]furanyl, quinolinyl, isoquinolinyl, —(CH 2 ) m -phenyl, naphthyl, fluorenyl, phthalamidyl, pyrimidinyl, or X 1 and X 2 are taken together with the nitrogen to which they are attached to form an optionally substituted moiety selected from the group consisting of thiazolyl Y 2 is CH—X 4 , N—X 4 , —C(X 4 X 4 ), O or S; X 4 for each occurrence is independently —(CH 2 ) m —Y 3 —X 5 ; Y 3 is —C(O)—, —C(O)O— or a bond; X 5 is hydroxy, (C 1 -C 12 )alkyl, amino, (C 1 -C 12 )alkylamino, N,N-di-(C 1 -C 12 )alkylamino, or an optionally substituted moiety selected from the group consisting of aryl, aryl(C 1 -C 4 )alkyl, furanyl, pyridinyl, indolyl, —CH(phenyl) 2 , where m for each occurrence is independently 0 or an integer from 1 to 6: R 5 is phenyl, o-methoxyphenyl, p-Br-phenyl, p-nitro-phenyl or p-N,N-diethylamino-phenyl; R 6 is H.