Patent ID: 8853275

Claim:
A concurrent therapy regime/regimen for inhibiting or treating an acne related disease, comprising: (a) topically applying onto the skin of an individual subject in need of such treatment, a therapeutically effective amount of a fixed-dose combination which comprises a retinoid which is adapalene and a topical antibacterial agent which is benzoyl peroxide, in the same vehicle, for a first predetermined period of time of 12 weeks; concurrently (b) orally administering to said individual subject a therapeutically effective amount of an oral antibiotic which is doxycycline hyclate with the fixed-dose combination for said first predetermined period of time of 12 weeks; and (c) optionally continuing the fixed-dose combination for another period of time as needed; wherein said concurrent steps (a) and (b) provide a synergistic effect; and wherein said synergistic effect is superior in terms of a resulting reduction in total lesions, reduction in inflammatory lesions, and reduction in non-inflammatory lesions when compared to a regime/regimen for inhibiting or treating an acne related disease with said fixed-dose combination or said oral antibiotic alone after 12 weeks of treatment.