Patent ID: 6936700

Claim:
A complex of the formula: wherein: M is a radionuclide metal or an oxide or nitride thereof: n=0 or 1; R 1 and R 2 are independently selected from hydrogen, ═O, with the proviso that both are not ═O, —(CH 2 ) m -Z where m is 0-10 and Z represents a conjugation group or targeting moiety, and —(CH 2 ) m —W where m is 0-10 and W represents a hydrolyzable group, or R 1 and R 2 are taken together to form a cyclic anhydride or a benzene ring; R 3 is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m -Z or —(CH 2 ) m —W; R 4 and R 5 are attached at one or more of the ring positions and are independently selected from hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m -Z and —(CH 2 ) m —W; R 6 and R 7 are independently selected from hydrogen with the proviso that both are not hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m -Z, —(CH 2 ) m —W— and where Q represents a multivalent acid functionality group able to coordinate with metal ions, and p=0 to 1; R 12 and R 13 are independently selected from hydrogen, hydroxyl, carboxyl, phosphoric, and hydrocarbon radicals having from 1-10 carbon atoms, and physiologically acceptable salts of the acid radicals; X, X′, Y and Y′ are carbon, to form member aromatic rings; A and A′ are oxygen, where an oxygen may bear a hydrogen; and the complex has at least one Z, W or Q.