Patent ID: 7507767

Claim:
A compound of the formula a prodrug thereof, or a pharmaceutically acceptable salt, or stereoisomer of the compound or of said prodrug; wherein: R 1 is H, alkyl, haloC 1 -C 6 alkyl, cycloalkyl, cycloalkylNH—, arylalkyl, heterocycloalkyl, heteroaryl, N(R 2 ) 2 , or NR 2 aryl, unsubstituted aryl or aryl substituted with one to three X; R 2 is the same or different in each occurrence and is independently selected from H or C 1 -C 6 alkyl; R 3 is H, C 1 -C 6 alkyl, Cl, F, CF 3 , OCF 2 H, OCF 3 , OH or C 1 -C 6 alkoxy; R 4 is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, cycloalkyl, alkenyl, aryl, benzyl, arylNH—, cycloalkylNH—, N(R 2 ) 2 , or NR 2 aryl, said alkyl, alkoxy, cycloalkyl, alkenyl, or aryl optionally substituted with one to three X; R 5 is H or C 1 -C 6 alkyl; R 6 is H or C 1 -C 6 alkyl; or R 5 and R 6 taken together with the carbon atom to form a carbonyl group; L 1 is —S(O 2 )—, —S(O)—, or —S—; L 2 is —S(O 2 )—, —S(O)—, or —S—; X is the same or different, and is independently selected from H, halogen, CF 3 , CN, OCF 2 H, OCF 2 CF 3 , OCF 3 , OR 2 , C 1 -C 6 alkyl, cycloalkyl, cycloalkoxy, C 1 -C 6 alkoxy, alkoxyC 1 -C 6 alkoxy, O-cycloalkyl, cycloalkylamino, cycloalkylalkoxy, heteroalkyl, —OSO 2 R 2 , —COOR 2 , —CON(R 2 ) 2 , NHR 2 , arylNH—, N(R 2 ) 2 , or NR 2 aryl; Y is a covalent bond, —CH 2 —, —S(O 2 )—, or Z is a covalent bond, —CH 2 —, —S(O 2 )— or or Y, R 1 , Z and R 2 can be taken together with the nitrogen atom to form a heterocycloalkyl; with the proviso that if Y is a covalent bond, R 1 cannot form a N—N bond with the nitrogen atom; and n is an integer of 0 to 4, with the proviso that, when R 1 ═R 2 ═H or lower alkyl, Y=Z=covalent bond, n=0 or R 3 at each occurrence is H, L 1 =L 2 =S or —S(O 2 )—, X=H, and R 4 is unsubstituted C 1 -C 6 alkyl or phenyl substituted once with —CON(H) 2 or —CON(Me) 2 , then R 5 and R 6 are each independently H or C 1 -C 6 alkyl.