Patent ID: 8710101

Claim:
A co-crystal of agomelatine, comprising: agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide of formula (I) and an organic acid which is in a solid state at ambient temperature, wherein the co-crystal is selected from: N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/para-hydroxybenzoic acid (2/1); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/para-hydroxybenzoic acid (1/2); N-[2-(7-methoxy-1-napthyl)ethyl]acetamide/citric acid (1/1); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/oxalic acid (2/1); N-[2-(7-methoxy-1-napthyl)ethyl]acetamide/gallic acid (2/1); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/maleic acid (1/1); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/malonic acid (1/1); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/glutaric acid (1/1); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/glycolic acid (1/1); and N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide/ketoglutaric acid (1/1).