Patent ID: 8518984

Claim:
A compound having Formula I: wherein: R 1a , R 1b , R 1c , and R 1d are independently selected from the group consisting of hydrogen, halogen, hydroxy, amino, nitro, cyano, alkoxy, aryloxy, optionally substituted alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, carboxamido, and sulfonamido; R 2 is selected from the group consisting of optionally substituted aryl and optionally substituted heteroaryl; R 3 is selected from the group consisting of optionally substituted alkyl, optionally substituted (cycloalkyl)alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted cycloalkenyl, optionally substituted aryl, and optionally substituted heteroaryl; R 4 is selected from the group consisting of hydrogen and optionally substituted C 1 -C 6 alkyl; R 5 is: wherein: each R 12a , R 12b , R 12c and R 12d is independently selected from the group consisting of hydrogen and optionally substituted C 1 -C 6 alkyl; R 13 is selected from the group consisting of hydrogen and optionally substituted C 1 -C 6 alkyl; R 14 is selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, and optionally substituted cycloalkyl; Z is selected from the group consisting of —OR 15 and —NR 16a R 16b ; or Z and R 14 taken together form a carbonyl group; R 15 is selected from the group consisting of hydrogen and metabolically cleavable group; R 16a is selected from the group consisting of —SO 2 R 16c and —CONR 16d R 16e ; R 16b is selected from the group consisting of hydrogen and optionally substituted alkyl; R 16c is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; R 16d and R 16e are each independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; or R 16d and R 16e taken together with the nitrogen atom to which they are attached form a 4- to 8-membered heterocyclo; o is 1, 2, or 3; p is 0, 1, 2, or 3; X is selected from the group consisting of O, S, and NR′; Y is selected from the group consisting of O, S, and NR″; R′ is selected from the group consisting of hydrogen, optionally substituted alkyl, aralkyl, and optionally substituted cycloalkyl; R″ is selected from the group consisting of hydrogen, optionally substituted alkyl, aralkyl, and optionally substituted cycloalkyl; and represents a single or a double bond, or a pharmaceutically acceptable salt thereof.