Patent ID: 8377925

Claim:
A method of treating, preventing, or controlling a melanocortin 5 receptor (MCR5)-associated condition, said condition selected from one or more conditions of the group consisting of acne, seborrhea, and seborrheic dermatitis comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of formula (Ib): wherein Y is CH 2 ; X is —C(═O)—; Z is —(CH 2 ) q —; r is 0 or 1; q is 1, 2, 3, or 4; R 1 is selected from the group consisting of (a) optionally substituted phenyl, biphenyl, or naphthyl; (b) optionally substituted indol-2-yl, indol-3-yl, quinolin-2-yl, quinolin-3-yl, isoquinolin-3-yl, quinoxaline-2-yl, benzo[b]furan-2-yl, benzo[b]thiophen-2-yl, benzo[b]thiophen-5-yl, thiazole-4-yl, benzimidazole-5-yl, benzotriazol-5-yl, furan-2-yl, benzo[d]thiazole-6-yl, pyrazole-1-yl, pyrazole-4-yl or thiophen-2-yl; and (c) optionally substituted alkenyl of the formula: wherein R 1c is optionally substituted C 6 -C 18 aryl wherein the C 6 -C 18 aryl is selected from phenyl and naphthyl; R 2 is H or C 1 -C 6 alkyl; R 3 is H or C 1 -C 6 alkyl; R 4 is NR 4a R 4b ; wherein R 4a is H, —C(═NH)NH 2 , —C(═NH)N(CH 3 ) 2 , —C(═NH)NHCH(CH 3 ) 2 , —C(═O)CH 3 , —C(═O)cyclohexyl, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH 3 , —CH(CH 3 )CH 2 CH 3 , CH 2 CH(CH 3 ) 2 , C(CH 3 ) 3 , cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, benzyl, and phenyl, and R 4b is H, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH 3 , CH(CH 3 )CH 2 CH 3 , CH 2 CH(CH 3 ) 2 , C(CH 3 ) 3 , cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, benzyl, and phenyl; or wherein R 4a and R 4b when taken together with the nitrogen atom to which they are attached form an optionally substituted heterocycloalkyl group selected from the group consisting of piperidin-1-yl, pyrrolidin-1-yl, azetidin-1-yl, azepan-1-yl, piperazin-1-yl, and morpholin-4-yl; R 5a and R 5b are each H; R 6 and R 8 are each independently H, methyl, trifluoromethyl, ethyl, 2,2,2-trifluoroethyl, isopropyl, isopropenyl, propyl, 2-ethyl-propyl, 3,3-dimethyl-propyl, butyl, 2-methylbutyl, isobutyl, 3,3-dimethyl-butyl, 2-ethyl-butyl, pentyl, 2-methyl-pentyl, optionally substituted phenyl or optionally substituted C 1 -C 5 heteroaryl wherein the C 1 -C 5 heteroaryl is thiophene, furan, pyrrole, imidazole, pyrazole, pyridine, pyrazine, or tetrazole; and R 7 is H; wherein each optional substituent is independently selected from the group consisting of F, Cl, Br, I, CH 3 , CH 2 CH 3 , OH, OCH 3 , CF 3 , OCF 3 , NO 2 , NH 2 , and CN; or a pharmaceutically acceptable salt thereof.