Patent ID: 6887474

Claim:
A method of inducing a thrombus in vivo comprising: administering a first agent that is a binding agent having a) a first component comprising an antibody or an antigen binding portion thereof that binds to a pre-selected site selected from the group consisting of tumor-associated antigens and tumor-specific antigens and b) a second component comprising a first ligand; administering an anti-ligand that specifically binds to the first ligand; administering a second agent that specifically binds to platelets, the second agent comprising von Willebrand factor and a second ligand that specifically binds to the anti-ligand; and binding platelets on the second agent and inducing activation of the platelets; thereby inducing a thrombus in vivo, wherein the first and second ligands and the anti-ligand consist of a complementary set of molecules that specifically bind to each other and are selected from the group consisting of biotin/avidin, zinc finger protein/dsDNA fragment, enzyme/inhibitor, hapten/antibody, ligand/receptor, homophylic peptides and leucine zipper sets.