Patent ID: 6951951

Claim:
A process for preparing a poly-pyrroleamido derivative of formula wherein P is a hydrogen atom or a suitable amino protecting group, which process comprises: a) hydrolysing distamycin A under basic conditions and properly protecting the resulting amino group so as to obtain a compound of formula wherein P is a suitable amino protecting group; b) reacting the compound of formula (II) with diphenylphosphorylazide (DPPA), so as to obtain a compound of formula c) hydrolysing under basic conditions the compound of formula (III) so as to obtain the derivative of formula d) reacting the compound of formula (IV) with a suitable guanylating agent so as to obtain the derivative of formula wherein P 1 and P 2 , the same, are hydrogen atoms or amino protecting groups equal or different to P; and when P 1 and P 2 are other than hydrogen atoms, e) deprotecting the guanidino and the amino group so as to obtain the derivative of formula (I).