Patent ID: 6890936

Claim:
A compound having the structural formula (I): or pharmaceutically acceptable salts or solvates thereof; wherein: R 1 is selected from the group consisting of H alkyl, alkenyl and alkynyl; R 2 is p is 0-4; m is 0-4; n is 0-4; R 3 is selected from the group consisting of H, alkyl, halo, alkoxy, hydroxy, nitro, aminoalkyl, and acyl, wherein R 3 can be the same or different and is independently selected when m is 2-4; R 4 and R 5 , which can be the same or different, are each independently selected from the group consisting of H and halogen; R 6 is selected from the group consisting of H, halo, alkyl, hydroxy, hydroxyalkyl, arylalkyl, aminoalkyl, haloalkyl, and thioalkyl, wherein R 6 can be the same or different and is independently selected when n is 2-4; R 7 is selected from the group consisting of hydrogen, acyl, alkyl, alkoxy, alkenyl, cycloalkyl, cycloalkyl substituted with 0-2 alkyl groups which can be the same or different and are independently selected, cycloalkenyl, bicycloalkyl, arylalkenyl and arylalkyl; R 8 is selected from the group consisting of H, alkyl, aryl, heteroaryl, halo, and cycloalkyl; R 9 is selected from the group consisting of H, alkyl, aryl, halo, hydroxy and cycloalkyl, wherein R 9 can be the same or different and is independently selected when (p) is 2-4, or two R 9 groups can be joined together to form the group —(CH 2 ) r —, wherein r is 1 to 6; R 10 is selected from the group consisting of substituted or unsubstituted alkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, with the proviso that when R 10 is a substituted or unsubstituted heteroaryl, the bond to M is from a carbon atom in the R 10 group; Z is N; X is selected from the group consisting of —O—, —S—, —S(O)—, —S(O) 2 —, —C(O)—, -alkylene-, —C(S)—, —C(alkyl) 2 - and —C(H)(alkyl)-; and M is —S(O) 2 — or —C(O)—.