Patent ID: 7048946

Claim:
An implant for controlled, sustained drug release comprising: a pharmacologically acceptable biodegradable polymer which is degraded at the site of implantation, wherein said biodegradable polymer comprises at least about 20 weight percent of the implant; a first therapeutically active agent at a concentration from 10 to 50 weight percent of the implant; a release modulator comprising hydroxy-propylmethylcellulose at a concentration from 10 to 50 weight percent of the implant, and said release modulator further comprising a second therapeutically active agent having a different activity than the first therapeutically active agent; wherein said implant is an anhydrous solid structure which is degraded at the site of implantation and releases said first therapeutically active agent within a therapeutic dosage which does not vary by more than about 100% for a period of at least about 3 days after implantation; wherein said anhydrous solid structure is a particle, sheet, plaque, fiber, microcapsule or disc.