Patent ID: 8232055

Claim:
A method for comparing the copy number of at least one nucleic acid sequence in at least two genomic sources, said method comprising: (a) preparing at least a first collection of nucleic acid molecules from a first genomic source and a second collection of nucleic acid molecules from a second genomic source, wherein said first and second genomic sources have a complexity of 1×10 8 base pairs or more and said first and second collections are of non-reduced complexity; (b) contacting said first and second collections of nucleic acid molecules with one or more pluralities of distinct oligonucleotide feature elements bound to a surface of a solid support, wherein said one or more pluralities of distinct oligonucleotide feature elements each consists essentially of oligonucleotide feature nucleic acids that range in size from 20 nt to 200 nt in length and said contacting occurs under stringent assay conditions; (c) measuring the binding of the first and second collections of nucleic acid molecules to said feature elements to produce data; and (d) identifying a quantitative difference in the copy number of at least one nucleic acid sequence in said at least two genomic sources using said data