Patent ID: 8227461

Claim:
A compound of formula I wherein X is CR 6 or N, wherein R 6 is hydrogen or lower-alkyl; R 1 is lower-alkyl, aryl or heteroaryl, wherein lower-alkyl is optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, hydroxy and lower-alkoxy, and wherein aryl and heteroaryl are each optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, lower-alkyl, lower-alkyl substituted by halogen, lower-alkyl substituted by hydroxy, lower-alkyl-C(O)OH, lower-alkyl-C(O)O-lower-alkyl, lower-alkyl-CO—NH 2 , lower-alkyl-CO—N(H,lower-alkyl), lower-alkyl-CO—N(lower-alkyl) 2 , lower-alkyl-NH 2 , lower-alkyl-N(H,lower-alkyl), lower-alkyl-N(lower-alkyl) 2 , lower-alkoxy-lower-alkyl, CO-lower-alkyl, COOH, COO-lower-alkyl, CONH 2 , CON(H,lower-alkyl), CON(lower-alkyl) 2 , cycloalkyl, heterocyclyl, aryl, heteroaryl, NH 2 , N(H, lower-alkyl), N(lower-alkyl) 2 , hydroxy, lower-alkoxy, phenyloxy, SO 2 -lower-alkyl, SO 2 —NH 2 , SO 2 —N(H,lower-alkyl) and SO 2 —N(lower-alkyl) 2 ; R 2 is hydrogen or lower-alkyl which is optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, lower-alkyl and lower-alkoxy; R 3 is hydrogen or lower-alkyl which is optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, hydroxy, lower-alkyl and lower-alkoxy; R 4 and R 5 are each independently selected from the group consisting of hydrogen, lower-alkyl, SO 2 -lower-alkyl, cycloalkyl and heterocyclyl, optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, hydroxy, lower-alkyl and lower-alkoxy, or wherein R 4 and R 5 , together with the nitrogen atom to which they are attached, form a heterocyclyl, optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, lower-alkyl and lower-alkoxy; with the proviso that R 4 and R 5 are not both H; or a pharmaceutically acceptable salt or ester thereof.