Patent ID: 7902199

Claim:
A compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt thereof wherein: G is —C≡N or X is N; Z is N, or NO; R 1 and R 2 are independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, and hydroxyalkyl; or alternatively, the N taken together with the R 1 and R 2 forms —N═C(NH 2 ) 2 , R 3 , R 5 and R 6 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, CF 3 , OCF 3 , haloalkyl, halogen, —N(R 30 ) 2 and —OR 30 ; R 7 and R 6 are the same or different, each being independently selected from the group consisting of H, and alkyl; or alternatively R 7 and R 8 taken together with the carbon atom to which they are shown attached is —C═O; the R 10 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, hydroxyl, —N(R 30 ) 2 , —OR 30 , and halogen; or wherein two R 10 moieties together on the same carbon atom form —C═O; the R 11 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, hydroxyl, —N(R 30 ) 2 , —OR 30 , and halogen; or wherein two R 11 moieties together on the same carbon atom form —C═O; R 12 is selected from the group consisting of H, alkyl, haloalkyl and CF 3 ; D is a phenyl, which is unsubstituted or substituted with 1-5 independently selected R 20 moieties; the R 20 moieties can be the same or different, each being independently selected from the group consisting of alkyl, cyano, halogen, haloalkyl, haloalkoxy, —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q N(R 31 ) 2 , —N(R 30 ) 2 , OR 30 , —SO 2 N(R 30 ) 2 , and —SO 2 (R 31 ); Y is selected from the group consisting of —(CR 13 R 13 ) r —, —CHR 13 C(═O)—, and —C(═O)—; the R 13 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, and alkoxy; the R 30 moieties can be the same or different, each being independently selected from the group consisting of H and alkyl; the R 31 moieties are independently alkyl; m is 0 to 4; n is 0 to 4; each q can be the same or different, each being independently selected from 1 to 5; and r is 1 to 4; wherein: “alkyl” refers to C 1 -C 6 alkyl; “cycloalkyl” refers to C 3 -C 10 cycloalkyl; and “aryl” refers to C 6 -C 10 aryl.