Patent ID: 7160512

Claim:
A method for manufacturing a biochip with spots of plural kinds of samples densely aligned on a substrate, wherein a sample containing a reagent specifically reactive with a specimen and providing information relating to the structure and functions of the specimen is introduced into a cavity via a sample charge port of a discharge unit having a sample charge port, a cavity, and a sample discharge port formed thereon, a substrate is provided at the position facing to the sample discharge port, the sample having been introduced into the cavity is discharged onto the substrate from the sample discharge port as droplets with a very small volume, thereby forming spots on the substrate, and the process is repeated for a plural kinds of the above-mentioned samples; said biochip manufacturing method comprising the steps of: providing a discharge head equipped with one or more discharge modules each of which being formed from one or more discharge units, providing means for rotating said discharge head by an angle of θ to correct for deviations in the rotational position of the discharge head; introducing at least one of said plural kinds of samples into a cavity from a sample charge port of the discharge unit in the discharge head, so that one discharge unit is provided with only one kind of sample, providing a first moving table, on which one or more trays with one or more substrates fixed thereon are detachably mounted, said first moving table being movable along two axes within the plane of at least one substrate, transferring said first moving table to a sample discharge point of the discharge unit corresponding to a predetermined point on the substrate, and discharging the sample having been introduced into the cavity from the sample discharge port to a predetermined point on the substrate as liquid droplets, thereby spots of plural kinds of samples are densely aligned on the substrate.