Patent ID: 8246981

Claim:
A composition for transdermal administration of an antiemetic comprising: a skin-contacting composition comprising a mixture of: i. an antiemetically effective amount of a 5-HT 3 receptor antagonist that is granisetron; ii. a permeation enhancing amount of permeation enhancer comprising at least 4% but less than 10% by weight of fatty acid ester wherein said fatty acid ester is of fatty acyl chain length C 12 -C 18 , and wherein said permeation enhancer is less than 10% by weight of the skin-contacting composition; and iii. an adhesive, wherein a single application of the composition provides a plasma concentration of the 5-HT 3 receptor antagonist in a therapeutically effective range period of time from an onset time to 12 hours or more after the composition is removed, wherein the onset time is 6 hours or less after application time; and provides 75% or more of the area under the curve achieved by a standard of oral dosing of the same 5-HT 3 receptor antagonist (either in single or divided doses) for 3 days and, if the composition is applied for five days, provides a mean cumulative irritation score less than 2; and provides a plasma concentration of the 5-HT 3 , receptor antagonist of from 1 ng/ml to 12 ng/ml from 6 hours after application to 120 hours after application, and from 2 ng/ml to 12 ng/ml from 24 hours after application to 96 hours after application, wherein properties provided by a single application would be provided by a single application of the skin-contacting composition to 25 cm 2 of skin.