Patent ID: 8383616

Claim:
A compound having the general formula I wherein, X is halogen, alkyl, alkenyl, haloalkyl, aryl, heteroaryl, benzyl, amino, alkylamino, or aminocarbonyl; Y and Z, the same or different, are halogen, nitro, haloalkyl, R 3 , OR 3 , amino, alkylamino, or aminocarbonyl; R 3 is hydrogen or alkyl; R 1 is NHC(=D)ER 4 or NR 5 R 6 ; D is O or S; E is O, NR 7 or is absent; R 7 is hydrogen or alkyl; R 4 is alkyl optionally substituted once with alkoxy or amino; alkenyl, aryl optionally substituted once or more with alkoxy, halo or heterocycloalkylalkyl; cycloalkyl optionally substituted once or more with alkyl, haloalkyl, alkoxy, amino or aminoalkyl; norbornyl, adamantyl, heteroaryl optionally substituted once or more with alkyl, alkylaminocarbonyl; heterocycloalkyl optionally substituted once or more with alkyl; or heterocycloalkylalkyl optionally substituted once or more with alkyl; R 5 and R 6 independently are hydrogen, alkyl, cycloalkyl, heterocycloalkyl optionally substituted once or more with alkyl; alkenyl, benzyl, aryl, arylalkyl optionally substituted with alkoxy; heteroaryl, heteroarylalkyl optionally substituted once or more with alkyl, hydroxyalkyl, alkoxy, alkoxycarbonyl; or R 5 and R 6 taken together with the nitrogen atom to which they are attached can form an optionally substituted 5 to seven-membered heterocycle ring, which optional substitution being halogen, hydroxyl, alkoxyl, alkyl, aryl, arylalkyl, alkylcarbonyl or aminocarbonyl; R 2 is NR 8 R 9 ; R 8 and R 9 , the same or different are chosen from H, alkyl optionally substituted with halogen; haloalkyl, aryl, cycloalkyl, heterocycloalkyl and heteroaryl; or R 8 and R 9 , taken together with the nitrogen atom to which they are attached, form a heterocycle that may contain one or two further heteroatoms selected from O, S or N and which can optionally be substituted once or twice with alkyl or halogen; and their tautomers, their geometrical isomers, their optically active forms such as enantiomers, diastereomers and their racemate forms, as well as their pharmaceutically acceptable salts thereof.