Patent ID: 7244727

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein X is N; Y is selected from the group consisting of N and N(R 2 ); Z is O; W 1 is a substituted or unsubstituted member selected from the group consisting of cyclo(C 3 -C 8 )alkyl, heterocyclo(C 3 -C 8 )alkyl, aryl and heteroaryl; W 2 is a substituted or unsubstituted member selected from the group consisting of cyclo(C 3 -C 8 )alkyl, heterocyclo(C 3 -C 8 )alkyl, aryl and heteroaryl; L 1 is selected from the group consisting of a bond, (C 1 -C 4 )alkylene, (C 2 -C 4 )alkenylene, O and N(R a )C(O); L 2 is selected from the group consisting of a bond, O, (C 1 -C 4 )alkylene, (C 2 -C 4 )alkenylene, (C 1 -C 4 )heteroalkylene and N(R a )C(O); the subscript m is 0 or 1; optionally, when m is 1 and L 2 is a bond, a substituent on W 2 may be combined with a substituent on W 1 to form a 5-, 6- or 7-membered ring fused to W 1 and spiro or fused to W 2 , wherein said ring is saturated or unsaturated and has 0, 1 or 2 heteroatoms selected from the group consisting of N, O and S as ring members; each R 1 is independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, fluoro(C 1 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, C(O)R a , CO 2 R a and C(O)NR a R b ; each R 2 is independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, fluoro(C 1 -C 8 )alkyl, C(O)R a , CO 2 R a , C(O)NR a R b , aryl and aryl(C 1 -C 4 )alkyl; R 3 and R 4 are independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, C(O)R a , CO 2 R a , C(O)NR a R b and (C 1 -C 4 )alkylene-OR a ; optionally, R 3 and R 4 may be combined to form a 3-, 4-, 5- or 6-membered spiro ring; optionally, R 2 , R 3 or R 4 may be combined with W 1 to form a 5-, 6- or 7-membered fused ring having from 0 to 3 heteroatoms selected from the group consisting of N, O and S; R 5 and R 6 are independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, C(O)R a and CO 2 R a ; optionally, R 5 and R 6 may be combined with the nitrogen atom to form a 5-, 6- or 7-membered ring; optionally, when X is C(R 1 ) or when Y includes an R 1 or R 2 group, R 5 or R 6 may be combined with R 1 or R 2 to form a 5-, 6- or 7-membered fused ring containing the nitrogen atom to which R 5 or R 6 is attached; R 7 is selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 4 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, and C(O)R a , optionally, when X is C(R 1 ), R 7 may be combined with R 1 to form a 5-, 6- or 7-membered fused ring; each R a and R b is independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, fluoro(C 1 -C 8 )alkyl, aryl and aryl(C 1 -C 4 )alkyl; and the dotted line indicates an optional bond.