Patent ID: 8268880

Claim:
A compound represented by: or a pharmaceutically acceptable salt thereof; wherein A represents a 4-8 membered heterocycle including the N and the Cα carbon; R 1 represents a C-terminally linked amino acid residue or amino acid analog R 6 ; wherein the bond between R 1 and N is a thioxamide bond; R 2 is absent or represents one or more substitutions to the ring A, each of which is independently a halogen, lower alkyl, lower alkenyl, lower alkynyl, carbonyl, carboxyl, ester, formate, ketone, thiocarbonyl, thioester, thioacetate, thioformate, amino, acylamino, amido, nitro, sulfate, sulfonate, sulfonamido, —(CH 2 ) m —R 7 , —(CH 2 ) m —OH, —(CH 2 ) m —O-lower alkyl, —(CH 2 ) m —O-lower alkenyl, —(CH 2 ) n —O—(CH 2 ) m —R 7 , —(CH 2 ) m —SH, —(CH 2 ) m —S-lower alkyl, —(CH 2 ) m —S-lower alkenyl, or —(CH 2 ) n —S—(CH 2 ) m —R 7 , azido, cyano, isocyanato, thiocyanato, isothiocyanato, cyanato, or R 3 represents hydrogen or a halogen, lower alkyl, lower alkenyl, lower alkynyl, carbonyl, thiocarbonyl, amino, acylamino, amido, nitro, sulfate, sulfonate, a sulfonamido, —(CH 2 ) m —R 7 , —(CH 2 ) m —OH, —(CH 2 ) m —O-lower alkyl, —(CH 2 ) m —O-lower alkenyl, —(CH 2 ) n —O—(CH 2 ) m —R 7 , (CH 2 ) m —SH, —(CH 2 ) m —S-lower alkyl, —(CH 2 ) m —S-lower alkenyl, or —(CH 2 ) n —S—(CH 2 ) m —R 7 , azido, cyano, isocyanato, thiocyanato, isothiocyanato, cyanato, or R 6 represents hydrogen, a halogen, alkyl, alkenyl, alkynyl, aryl, —(CH 2 ) m —R 7 , —(CH 2 ) m —OH, —(CH 2 ) m —O-alkyl, —(CH 2 ) m —O-alkenyl, —(CH 2 ) m —O-alkynyl, —(CH 2 ) m —O—(CH 2 ) m —R 7 , —(CH 2 ) m —SH, —(CH 2 ) m —S-alkyl, —(CH 2 ) m —S-alkenyl, —(CH 2 ) m —S-alkynyl, —(CH 2 ) m —S—(CH 2 ) m —R 7 , R 7 represents, for each occurrence, a substituted or unsubstituted aryl, aralkyl, cycloalkyl, cycloalkenyl, or heterocycle; R 8 represents hydrogen, —CH 3 , or —(CH 2 ) n —CH 3 ; Y 1 and Y 2 , independently, are OH, or a group capable of being hydrolyzed to a hydroxyl group, or Y 1 and Y 2 are connected via a ring having from 5 to 8 atoms in the ring structure which is capable of being hydrolyzed to two hydroxyl groups; m is zero or an integer in the range of 1 to 8; and n is an integer in the range of 1 to 8.