Patent ID: 8518969

Claim:
A compound of Formula I wherein: A is X is N; Z is N; J is N or CH; Q is C—R 5 , provided that J is N, or Q is N, provided that J is CH; R 1 is H, phenyl, heteroaryl, CF 3 , —CH═CH 2 , CO 2 C (1-4) alkyl, NHBOC, NHC (1-4) alkyl, N(C (1-4) alkyl)CO 2 CH 2 Ph, NR b C(O)R bb , NR b SO 2 R bb , C(O)N(CH 3 )OCH 3 , C(O)NR b C (1-4) alkyl, C(O)NHCH 2 Ph(OCH 3 ) 2 , —C(OH)(CH 2 CH═CH 2 ) 2 , 3,6-dihydropyran-2-yl, 2,5-dihydrofuran-2-yl, tetrahydropyranyl, cyclopentenyl, cyclopentanyl, cyclohexenyl, cyclohexanyl, tetrahydrofuran-2-yl, cycloheptanyl, or unsubstituted or substituted C (1-6) alkyl wherein said alkyl may be substituted with up to two substituents wherein one substituent is selected from the group consisting of OH, C (2-4) alkenyl, C (3-6) cycloalkyl, NH 2 , NHBOC, N(C (1-4) alkyl) 2 , NHSO 2 R b , NR b C(O)R bb , NHCO 2 R b , NHCONR b R bb , OC (1-2) alkyl, OC(O)C (1-4) alkyl, OC(O)NR b R bb , CO 2 C (1-4) alkyl, C(O)NR b R bb , C (2) alkylnyl, thiazolyl, oxazolyl, furyl, CF 3 , CF 2 CF 2 CF 3 , CH 2 NHCOC (1-3) alkyl, N 3 , SCH 3 , S(O)CH 3 , SO 2 CH 3 and —CN, and the second substituent on the C (1-6) alkyl is OH, and wherein said phenyl or heteroaryl is optionally substituted with one substituent selected from the group consisting of: OH, —CN, CH 2 OH, OC (1-4) alkyl, NH 2 , NHC (1-4) alkyl, OC (1-4) alkyl, C(O)C (1-4) alkyl, CO 2 C (1-4) alkyl, C(O)NHC (1-4) alkyl, CO 2 NHC (1-4) alkyl, SC (1-4) alkyl, SOC (1-4) alkyl, SO 2 C (1-4) alkyl, SO 2 NHC (1-4) alkyl, NHSO 2 C (1-4) alkyl, NHCO 2 C (1-4) alkyl, NHC(O)C (1-4) alkyl, NO 2 , and C (1-4) alkyl; R 2 is H, or OH; or R 1 and R 2 may together form a carbonyl; R 3 is H, C (1-4) alkyl, —CN, CHF 2 , or CF 3 ; R 4 is H or CH 3 ; R 5 is H or deuterium; R a is H, or CH 3 ; R b is H, C (1-4) alkyl, or CF 3 ; R bb is H, C (1-4) alkyl, or CF 3 ; and pharmaceutically acceptable salts thereof.