Patent ID: 7553979

Claim:
A compound of structure IIa or IIb wherein R and R 3 are independently selected from OR 10 , optionally substituted lower alkyl and H; R 2 is —OCH 3 ; R 5 is selected from H, lower alkyl, aryl and perhaloalkyl; R 10 is selected from H, lower alkyl, aryl, C(O)NR 11 2 , C(O)OR 11 and C(O)R 11 ; R 11 is selected from H, optionally substituted alkyl and aryl; L is O; “a-b-” is selected from -E-CH 2 —, -E-C(O)—, and —(O)C-E; “-c-d-” is selected from CH(OH)—CH(OH), CH═CH, O═C—CH 2 , and CH 2 C═O; and E is O; wherein the substituents of an optionally substituted group are independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, aryloxy, haloalkoxy, amino, alkylamino, dialkylamino, alkylthio, arylthio, heteroarylthio, oxo, oximes, carboxyesters, carboxamido, acyloxy, F, Cl, Br, I, ON, NO 2 , N 3 , C(O)CH 3 , CO 2 CH 3 , CO 2 H, C(O)NH 2 , OR 17 , SR 17 and NR 18 R 19 , wherein R 17 is selected from hydrogen C1-C8 alkyl, C1-C8 heteroalkyl, C1-C8 haloalkyl, C2-C8 alkenyl, C2-C8 heteroalkenyl, C2-C8 haloalkenyl, C2-C8 alkynyl, C2-C8 heteroalkynyl, C2-C8 haloalkynyl, aryl, and heteroaryl wherein said alkyl, heteroalkyl, haloalkyl, alkenyl, heteroalkenyl, haloalkenyl, alkynyl, heteroalkynyl, haloalkynyl, aryl and heteroaryl groups are optionally substituted with F, Cl, Br, I, N0 2 , CN, OR 18 , SR 18 , NR 18 R 19 , C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkynyl, C2-C6 alkenyl, or allyl, and wherein R 18 and R 19 are each independently selected from hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, and C1-C6 haloalkyl; or a pharmaceutically acceptable salt thereof.