Patent ID: 8258296

Claim:
A process for preparing a crystalline Form VI of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one comprising recrystallizing (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one from a solution or suspension of (1R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one in water and an organic solvent selected from the group consisting of ethanol, methanol, isopropanol, n-propanol, and acetone; and wherein Form VI has at least one property selected from the group consisting of: a characteristic X-ray powder diffraction (XRPD) pattern comprising 2-theta positions at about 10.1, 12.1, 13.3, 14.5, 15.0, 16.0, 16.6, 17.0, 17.4, 18.8, 19.2, 19.7, 21.1, 22.3, 23.9, 24.2, 24.8, 25.7, 26.7, 27.6, 28.6, 28.9, 29.3, 29.7, 30.0, 30.5, 30.8, 31.3, 33.3, 33.7, 34.3, 35.0, 35.5, 36.5, 36.7, 37.4, and 39.5+/−0.2; a characteristic X-ray powder diffraction (XRPD) pattern comprising 2-theta positions at about 10.1, 14.5, 16.0, 21.1, 24.8, and 25.7+/−0.2; a characteristic X-ray powder diffraction (XRPD) pattern comprising 2-theta positions at about 14.5, 16.0, 21.1, 24.8, and 25.7+/−0.2; a characteristic X-ray powder diffraction (XRPD) pattern comprising 2-theta positions at about 21.1, 24.8, and 25.7+/−0.2; a characteristic X-ray powder diffraction (XRPD) pattern comprising a 2-theta position at about 10.1+/−0.2; an X-ray powder diffraction pattern substantially similar to that presented in FIG. 16 ; an infrared spectra substantially similar to that presented in a figure selected from the group consisting of FIG. 17 a , FIG. 17 b , FIG. 17 c , and FIG. 17 d; an infrared spectra having characteristic infrared spectral peak positions at 1607, 1555, 1468, 1400, 1361, 1316, 1280, 1218, 1165, 1102, 1014, 976, 938, 760, and 698 cm −1 ; and a differential scanning calorimetry thermogram substantially similar to that presented in a figure selected from the group consisting of FIG. 18 a , FIG. 18 b , and FIG. 18 c.