Patent ID: 7459468

Claim:
A compound of the formula: wherein A) R 1 is —OH; —O-alkyl; —(CH 2 ) n′ OH where n′ is an integer from 1 to 8; alkyl; cycloalkyl; or O-alkyl-aryl-R 4 , where R 4 is —CN or amidine; R 2 is (CH 2 ) n -aryl-R 5 where n is an integer from 0 to 8 and R 5 is SO 2 NH 2 or SO 2 NHC(CH 3 ) 3 ; (CH 2 ) n -aryl-aryl-R 5 , where n and R 5 are as defined above, or —(CH 2 ) n —NH-aryl-R 5 , where n and R 5 are as defined above; and R 3 is —(CH 2 ) n OH where n is as defined above; (CH 2 ) n —NH-aryl-R 5 , where n and R 5 are as defined above; (CH 2 ) n —NH—CO-aryl-R 5 where n and R 5 are as defined above; (CH 2 ) n —NH-aryl-aryl-R 5 where n and R 5 are as defined above; or (CH 2 ) n —NH—CO-aryl-aryl-R 5 where n and R 5 are as defined above; or B) R 1 is —OH; —O-alkyl; —(CH 2 ) n′ OH where n′ is an integer from 1 to 8; alkyl; cycloalkyl; or O-alkyl-aryl-R 4 , where R 4 is —CN or amidine; R 2 is alkyl; —(CH 2 ) n′ OH where n′ is as defined above; —(CH 2 ) n COOH where n is an integer from 0 to 8; —(CH 2 ) n COO(CH 2 ) n CH 3 where n is as defined above; (CH 2 ) n -aryl-R 5 where n is as defined above and R 5 is SO 2 NH 2 or SO 2 NHC(CH 3 ) 3 ; (CH 2 ) n -aryl-aryl-R 5 , where n and R 5 are as defined above, or —(CH 2 ) n -NH-aryl-R 5 , where n and R 5 are as defined above; R 3 is (CH 2 ) n —NH-aryl-R 5 , where n and R 5 are as defined above; (CH 2 ) n —NH—CO-aryl-R 5 where n and R 5 are as defined above; (CH 2 ) n —NH-aryl-aryl-R 5 where n and R 5 are as defined above; or (CH 2 ) n —NH—CO-aryl-aryl-R 5 where n and R 5 are as defined above and R 1 and R 2 when taken together form a compound of formula II, wherein R 3 is as defined above; or a pharmaceutically acceptable salt thereof.