Patent ID: 7928062

Claim:
An in vivo method of suppressing undesired Janus tyrosine kinase 3 (Jak3)-dependent proliferation of a cell expressing Janus tyrosine kinase 3 in a mammalian subject in need thereof comprising: contacting said cell with at least one compound of the formula (I) wherein R 1 is H, ═CH 2 , CH 2 N(CH 3 ) 2 , CH 2 SC(O)CH 3 , CH 2 SC 6 H 5 , CH 2 SCH 2 -(4-C 6 H 4 OCH 3 ), CH 2 SC(O)C 6 H 5 or CH 2 N(CH 2 CH 3 ) 2 ; R 2 is O; R 3 is CH 2 N(CH 3 ) 2 , CH 2 N(CH 2 CH 3 ) 2 or CH 2 —(N-morphyl); or a salt thereof, in an amount effective to interfere with the signal 3 pathway in the cell and thereby suppressing proliferation of said Jak3-expressing cell, wherein the mammalian subject is an organ transplant recipient or a mammalian subject suffering from T-cell mediated autoimmune disease, airway hypersensitivity, or allergic reaction wherein said contacting comprises administering to said subject a therapeutically effective amount of a pharmaceutical composition containing said at least one compound, or pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.