Patent ID: 7598253

Claim:
A method for treating a cell adhesion-mediated disease comprising administering to a warm-blooded animal in need thereof a composition comprising a therapeutically effective amount of a compound having the structure: wherein Y is selected from —CH(R 5 )—A—N(R 1 )—, —A—N(R 1 )—CH(R′)—, —A—N(R 1 )—C(═O)—, —A—C(═O)—N(R 1 )—, —A—CH(R 1 )—O— and —A—CH(R 1 )—N(R′)—; A is —(CHR′) n —, where n=0, 1 or 2; B is —(CHR″) m —, where m=1, 2 or 3; R′, R″, R 2 , R 3 and R 5 are the same or different and independently selected from an amino acid side chain moiety or an amino acid side chain derivative; and R 1 and R 4 are the same or different and independently selected from an amino acid, and amino acid side chain moiety, an amino acid side chain derivative, a peptide, a peptide derivative, or a protein; and wherein any two adjacent CH groups or adjacent NH and CH groups on the fused bicyclic ring may optionally form a double bond; in combination with a pharmaceutically acceptable carrier or diluent.