Patent ID: 7038067

Claim:
A process of forming a d-tocotrienol comprising: a) providing a (2S)-vinylchroman compound having the formula shown by (I), in single enantiomer form; b) converting said (2S)-vinylchroman compound of (I) to an organoborane having the formula shown by (II) by way of a hydroboration reaction; and c) providing 1-bromo-2,6,10-trimethylundeca-1E,5E,9-triene or 1-iodo-2,6,10-trimethylundeca-1E,5E,9-triene; d) coupling said organoborane of (H) with 1-bromo-2,6,10-trimethylundeca-1E,5E,9-triene or 1-iodo-2,6,10-trimethylundeca-1E,5E,9-triene, under conditions of palladium-catalyzed cross-coupling to form a d-tocotrienol product of formula (III), wherein R 1 is a hydrogen atom or methyl group, R 2 is a hydrogen atom or methyl group, and R 3 is a methyl group, except that R 1 and R 2 are not both methyl groups, further wherein P is a hydrogen atom or a protecting group.