Patent ID: 7229983

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof: wherein: one of A and B denotes hydrogen and the other is a fused bicyclic heteroaryl group or a fused tricyclic heteroaryl group; R 1 is H, optionally substituted —C1–C6 alkyl, optionally substituted -aryl, optionally substituted -heteroaryl or mono or bicyclic saturated heterocycles, optionally substituted —C3–C7 cycloalkyl, optionally substituted —C3–C6 alkenyl, optionally substituted —C3–C6 alkynyl with the proviso that both the double bond and the triple bond should not be present at the carbon atom which is directly linked to N; optionally substituted —C1–C6 per fluoro alkyl, —S(O) p optionally substituted alkyl or aryl where p is 2, optionally substituted —C═Oheteroaryl, optionally substituted —C═Oaryl, optionally substituted —C═O(C1–C6) alkyl, optionally substituted —C═O(C3–C6) cycloalkyl, optionally substituted —C═O mono or bicyclic saturated heterocycles, optionally substituted C1–C6 alkyl aryl, optionally substituted C1–C6 alkyl heteroaryl, optionally substituted aryl-C1–C6 alkyl, optionally substituted heteroaryl-C1–C6 alkyl, optionally substituted C1–C6 alkyl mono or bicyclic saturated heterocycles, optionally substituted arylalkenyl of 8 to 16 carbon atoms, —CONR 6 R 7 , —SO 2 NR 6 R 7 , optionally substituted arylalkyloxyalkyl, optionally substituted -alkyl-O-alkyl-aryl, optionally substituted -alkyl-O-alkyl-heteroaryl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted aryloxyaryl, optionally substituted aryloxyheteroaryl, optionally substituted C1–C6alkyl aryloxyaryl, optionally substituted C1–C6 alkyl aryloxyheteroaryl, optionally substituted alkyl aryloxy alkylamines, optionally substituted alkoxy carbonyl, optionally substituted aryloxy carbonyl, or optionally substituted heteroaryloxy carbonyl; R 3 is hydrogen, C1–C6 alkyl, C3–C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; R 5 is H, C1–C6 alkyl, C5–C6 cycloalkyl, or salts selected from the group Na, K, and Ca; R 6 and R 7 are independently H, optionally substituted C1–C6 alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1–C6 alkyl aryl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted C1–C6 alkyl heteroaryl, R 6 and R 7 can be together to form a 3–7 membered saturated ring system optionally having one or two heteroatoms selected from the group N—R 1 , O, and S═(O) n ; n=0–2; and R 8 is N—R 6 R 7 , optionally substituted C1–C6 alkoxy, hydroxy, optionally substituted —S—C1–C6 alkyl, optionally substituted —O-Aryl, optionally substituted —O—C1–C6-alkyl-aryl, optionally substituted —O-aryl alkyl(C1–C6), optionally. substituted —S-Aryl, optionally substituted —S—C1–C6-alkyl-aryl, optionally substituted —S-aryl-alkyl(C1–C6), —S— optionally substituted C1–C6 alkyl-COO—H, or —S— optionally substituted C1–C6 alkyl-COO—C1–C6 alkyl.