Patent ID: 8921383

Claim:
A compound of Formula I wherein: R 1 is phenyl, optionally substituted with one or more lower alkyl, lower haloalkyl, hydroxy, hydroxy lower alkyl, lower alkoxy, lower alkyl sulfonyl, halo, nitro, amino, aminoalkyl, amido, cyano, oxo, or R 1′ ; R 1′ is heterocycloalkyl or spiro heterocycloalkyl, each optionally substituted with one or more R 1″ ; R 1″ is hydroxy, halo, lower alkyl, lower alkoxy, or lower haloalkyl; B is phenyl, pyridinyl, pyrrolidinyl, or piperidinyl; X is OH, lower alkoxy, NHC(═O)Y, C(═O)NH 2 , C(═O)NHY, C(═O)X′, C(═O)Y, CH 2 NHY, CH 2 CH 2 Y, CF═CHY, CH═CHY, CH 2 OH, C(═O)NHCH 2 CH 2 N(CH 3 ) 2 , or C(═O)NHCH 2 CH 2 Y; X′ is OH or lower alkoxy; Y is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each optionally substituted with one or more Y 3 ; Y 3 is hydroxy, lower alkyl, lower alkoxy, halo, oxo, lower haloalkyl, hydroxy lower alkyl, amino, amido, C(═O)NH(CH 3 ), C(═O)OH, C(═O)OY 4 , or heteroaryl optionally substituted by with one or more lower alkyl, oxo or SH; Y 4 is lower alkyl; or a pharmaceutically acceptable salt thereof.