Patent ID: 6838472

Claim:
A compound according to structural formula (1): or a pharmaceutically available salt, solvate or hydrate thereof wherein: n is an integer from 0 to 2; X is S, O or NR 4 ; R 4 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl; A is aryl or pyridinyl; Y is CO 2 R 6 , C(O)SR 7 or C(O)NR 8 R 9 ; R 1 independently hydrogen, alkyl, arylalkyl wherein the aryl radical is a phenyl ring optionally substituted with one to three, substituents selected from the group consisting of acyl, alkyl, acylamino, alkoxycarbonyl, alkyamino, alkylsulfinyl, alkylsufonyl, alkoxy, amino, carbamoyl, cyano, dialkylamino, ethylenedioxy, halo, haloalkyl, heteroalkyl, hydroxy, hydroxyalkyl, methylenedioxy, and nitro, cycloalkyl, cycloalkyl-alkyl, haloalkyl, heteroarylalkyl wherein the hetecroaryl radical is selected from the group consisting of furanyl, thienyl, thiazolyl, isothiazolyl, imidazolyl, isoxazolyl, pyrrolyl and pyrazolyl, heteroalkyl wherein one or more hydrogen atoms of said heteroalkyl radical have been replaced with the group—OR″ wherein R″ is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl or arylalkyl; R 3 is hydrogen or alkyl; R 2 is hydrogen, alkyl, hydroxy or oxo; R 6 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl; R 7 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl; R 8 and R 9 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl, or together with the nitrogen atom to which they are attached form a heterocyclyl ring; with the proviso that R 1 is not hydrogen or alkyl when R 3 is hydrogen.