Patent ID: 7989445

Claim:
A compound represented by the formula: wherein Ar is benzene or indane; A is —(CH 2 ) 2 —(CH 2 )CO; B is a bond, —CH 2 —, —(CH 2 ) 2 — or —CH(CH 3 )—; R 3 is a hydrogen atom or a hydroxy group; R 5 is a hydrogen atom; R 4 is 4-chlorophenyl or 4-fluorophenyl; and R 1 and R 2 are each independently (1) a hydrogen atom, (2) a C 1-6 alkyl group optionally substituted by 1 to 3 substituents selected from halogen atom, carboxy group, hydroxy group, C 1-6 alkoxy-carbonyl group, and carbamoyl group optionally mono- or di-substituted by C 1-6 alkyl group; (3) an amino group optionally substituted by 1 or 2 substituents selected from C 1-6 alkyl group, C 1-6 alkyl-carbonyl group, C 1-6 alkoxy-carbonyl group, C 6-14 aryl-carbonyl group, C 7-13 aralkyl-carbonyl group, C 1-6 alkylsulfonyl group, C 6-14 arylsulfonyl group and C 7-13 aralkylsulfonyl group; (4) a C 1-6 alkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from halogen atom, and amino group optionally mono- or di-substituted by C 1-6 alkyl group; (5) a C 3-10 cycloalkyl-carbonyl group; (6) a C 1-6 alkoxy-carbonyl group optionally substituted by 1 to 3 halogen atoms; (7) a C 1-6 alkylsulfonyl group optionally substituted by 1 to 3 halogen atoms; (8) a carbamoyl group optionally substituted by 1 or 2 substituents selected from C 1-6 alkyl group optionally substituted by 1 to 3 halogen atoms, C 6-14 aryl group and C 7-13 aralkyl group; or (9) a thiocarbamoyl group optionally mono- or di-substituted by C 1-6 alkyl group optionally substituted by 1 to 3 halogen atoms, or R 1 and R 2 are bonded to form piperidine, piperazine or pyrrolidine each optionally having 1 to 3 substituents selected from (1) a halogen atom; (2) a hydroxy group; (3) an oxo group; (4) a C 1-6 alkyl group optionally substituted by 1 to 3 substituents selected from halogen atom, carboxy group, hydroxy group, C 1-6 alkoxy-carbonyl group, and carbamoyl group optionally mono- or di-substituted by C 1-6 alkyl group; (5) an amino group optionally substituted by 1 or 2 substituents selected from C 1-6 alkyl group, C 1-6 alkyl-carbonyl group, C 1-6 alkoxy-carbonyl group, C 6-14 aryl-carbonyl group, C 7-13 aralkyl-carbonyl group, C 1-6 alkylsulfonyl group, C 6-14 arylsulfonyl group and C 7-13 aralkylsulfonyl group; (6) a C 1-6 alkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from halogen atom, and amino group optionally mono- or di-substituted by C 1-6 alkyl group; and (7) a C 1-6 alkoxy-carbonyl group optionally substituted by 1 to 3 halogen atoms, or R 1 and Ar are bonded to form benzazepane, or a salt thereof.