Patent ID: 7488490

Claim:
A method of inducing an antigen specific immune response in a subject, comprising: administering to the subject in order to induce an antigen specific immune response an antigen and a combination of adjuvants, wherein the combination of adjuvants includes at least one oligonucleotide containing at least one unmethylated CpG dinucleotide and at least one non-nucleic acid adjuvant, wherein the non-nucleic acid adjuvant is an immune stimulating adjuvant selected from the group consisting of PCPP polymer, derivatives of lipopolysaccharides, MPL, MDP, t-MDP, OM-174 and Leishmania elongation factor, wherein the combination of adjuvants is administered in an effective amount for inducing a synergistic adjuvant response, and wherein the oligonucleotide is 8-100 nucleotides in length and has at least one phosphorothioate backbone modification.