Patent ID: 8513002

Claim:
An apparatus for nucleic acid sequencing comprising: a reaction chamber having an immobilization surface for attachment of a nucleic acid molecule to be sequenced; a microfluidic channel coupled to the reaction chamber for transporting nucleotides released from the nucleic acid molecule; a microchannel coupled to the microfluidic channel at an entrance for receiving the nucleotides, a region of nanoparticles positioned within the microchannel, the region of nanoparticles being configured to allow passage of the nucleotides; an excitation source proximate the region of nanoparticles, the excitation source being configured to excite the nucleotides passing through the region of nanoparticles; and a detector configured to detect the excited nucleotides; wherein the detector comprises an analysis chamber comprising a resonant cavity to contain the nucleotides for analysis, a first window to the cavity to transmit a first electromagnetic radiation having a first frequency into the cavity and to transmit a second electromagnetic radiation having a second frequency out of the cavity, a second window to the cavity to transmit a transverse electromagnetic radiation having the second frequency into the cavity and a plurality of reflectors affixed to a housing of the cavity to reflect radiation of a predetermined frequency, the plurality of reflectors separated by a distance that is sufficient to resonate the radiation of the predetermined frequency.