Patent ID: 7790720

Claim:
A compound of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and mixtures thereof, wherein A 1 is CH; R 1 is hydrogen or halogen; R 2 is A 3 is O or S; R 3 is hydrogen, halogen, C 1-4 alkyl or C 1-4 alkoxy; R 4 is hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy or —O—(CH 2 ) n —NR 12a R 12b ; R 5 is hydrogen or —O—(CH 2 ) m —NR 13a R 13b ; R 10 is hydrogen, C 1-8 alkyl or —(CH 2 ) w —(C═O) t —NR 15 R 16 ; R 11 is hydrogen, C 1-8 alkyl, ester, carboxylic acid, halogen, or —(CH 2 ) r —(C═O) z —NR 17 R 18 ; R 12a and R 12b are linked together to form a C 3-6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1-4 alkyl; R 13a and R 13b are linked together to form a C 3-6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1-4 alkyl, an amino group or a C 1-6 alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a C 1-8 alkyl, C 3-6 cycloalkyl or C 1-6 alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C 3-6 alkylene; R 15 is hydrogen or C 1-4 alkyl; R 16 is aryl or C 1-8 alkyl; or R 15 and R 16 are linked together to form a C 3-6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1-4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by an C 1-6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C 3-6 cycloalkyl; or one methylene of the alkylene being optionally replaced by a C 3-8 cycloalkyl or a carbonyl; or R 15 and R 16 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a C 1-4 alkyl; R 17 is hydrogen or a C 1-8 alkyl; R 18 is C 1-8 alkyl, C 1-6 alkyl aryl or C 1-6 alkyl cycloalkyl; or R 17 and R 18 are linked together to form a C 3-6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1-4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C 1-8 alkyl or C 3-6 cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independently an integer comprised between 0 and 4; t and z are independently an integer equal to 0 or 1; with the proviso that R 4 is —O—(CH 2 ) n —NR 12a R 12b , when R 5 is hydrogen and that R 5 is —O—(CH 2 ) m —NR 13a R 13b , when R 4 is hydrogen, halogen, C 1-4 alkyl or C 1-4 alkoxy; with the proviso that when R 11 is an ester or a carboxylic acid, R 4 is hydrogen, C 1-4 alkyl or C 1-4 alkoxy; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.