Patent ID: 7276364

Claim:
A substantially purified protein, consisting of a protease domain of an endotheliase protein that has catalytic activity, wherein: the protease domain of the endotheliase is selected from the group consisting of: a) a polypeptide consisting of the sequence of amino acid residues set forth as amino acids 320-562 of SEQ ID No. 4; b) a polypeptide consisting of the sequence of amino acid residues set forth as amino acids 320-688 of SEQ ID No. 6; and c) a protease domain of an endotheliase protein consisting of a sequence of amino acid residues that has at least 95% sequence identity to the sequence of amino acids set forth as amino acid residues 320-562 in SEQ IN No. 4 or amino acid residues set forth as amino acid residues 320-688 of SEQ ID No.6.