Patent ID: 7205410

Claim:
A process for preparing a compound of formula (III) wherein a) an intermediate of formula (VIII), wherein PG is an appropriate protective group, is reacted with an acid of formula (VI), or an appropriate reactive functional derivative thereof, in a reaction-inert solvent and subsequent deprotection of the protecting group PG yielding compounds of formula (III); wherein in the above reaction scheme W is an appropriate leaving group; —R 1 —R 2 — is a bivalent radical of formula —O—CH 2 —O— (a-1), —O—CH 2 —CH 2 — (a-2), —O—CH 2 —CH 2 —O— (a-3), —O—CH 2 —CH 2 —CH 2 — (a-4), —O—CH 2 —CH 2 —CH 2 —O— (a-5), —O—CH 2 —CH 2 —CH 2 —CH 2 — (a-6), —O—CH 2 —CH 2 —CH 2 —CH 2 —O— (a-7), —O—CH 2 —CH 2 —CH 2 —CH 2 —CH 2 — (a-8), wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C 1-6 alkyl or hydroxy, R 3 is hydrogen or halo; R 4 is hydrogen or C 1-6 alkyl; and R 5 is hydrogen or C 1-6 alkyl; b) or, compounds of formula (III) are converted into each other following art-known transformation reactions; or if desired; a compound of formula (III) is converted into an acid addition salt, or conversely, an acid addition salt of a compound of formula (III) is converted into a free bsae form with alkali; and, if desired, preparing stereochemically isomeric forms thereof.