Patent ID: 6930116

Claim:
A compound of formula IA: or a pharmaceutically acceptable salt thereof, wherein R 1 is an optionally substituted group selected from a C 1-6 aliphatic group, —C(R 4 ) 2 (CH 2 ) n NRCOR, —C(R 4 )═N—OR, —C(R 4 )═N—OC(═O)(C 1-6 aliphatic), —C(R 4 )═NNRCO 2 (C 1-6 aliphatic), —C(R 4 )═NNRCOR, —C(R 4 )═NN(R) 2 , —C(R 4 ) 2 (CH 2 ) n NRCO 2 (C 1-6 aliphatic), —CO 2 (C 1-6 aliphatic), —CON(R) 2 , —C(R 4 ) 2 (CH 2 ) n CON(R) 2 , —C(R 4 ) 2 (CH 2 ) n SO 2 N(R) 2 , —CONH—OR, —SO 2 N(R) 2 , or —C(R 4 ) 2 (CH 2 ) n NRSO 2 (C 1-6 aliphatic); n is zero or one; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group; R 2 is selected from hydrogen or, when R 1 is —CO 2 (C 1-3 aliphatic) or —CONH(C 1-3 aliphatic), R 2 is further selected from -halo, —CN, —C 1-4 aliphatic, a three to five-membered heterocyclyl, or a five-membered heteroaryl; Ring A is a heteroaryl ring selected from thiazole, oxazole, imidazole or pyrazole, wherein said imidazole is optionally attached by a C 1-3 bridge from an imidazole ring nitrogen to Ar to form a five- to seven-membered fused ring; Z is C—R 3 or N—R 3 ; R 3 is —(CH 2 ) p N(R 5 ) 2 or an optionally substituted group selected from C 1-8 aliphatic, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; each R 4 is indepependently selected from hydrogen, an optionally subtituted C 1-6 aliphatic group, or two R 4 taken together with the carbon to which they are attached form a three to six membered aliphatic ring; each R 5 is independently selected from hydrogen, an optionally subtituted C 1-4 aliphatic group, or two R 5 taken together with the nitrogen to which they are attached form a five or six membered heterocyclic ring; p is an integer from zero to four when Z is C—R 3 or an integer from one to four when Z is N—R 3 ; and Ar is an optionally substituted aryl, heteroaryl, or heterocyclyl ring.