Patent ID: 8222291

Claim:
A compound having the formula (1): or a pharmaceutically acceptable salt or hydrate form thereof; and including any stereoisomeric forms thereof; wherein each J and J′ is independently H, CN, C1-C4 alkyl or C1-C4 alkyloxycarbonyl; each Y and Y′ independently represents optionally substituted C1-C8 alkyl, C5-C12 aryl, C5-C20 arylalkyl, or a heteroform of one of these; or is ═O, OR, SR, S(O)R, SO 2 R, SO 2 NR 2 , NR 2 , OC(O)R, NRC(O)R, NRCOOR, NRC(O)NR 2 , NRSO 2 R, CN, C(O)NR 2 , C(O)R, COOR, NO 2 or halo, wherein each R is independently H, C 1 -C 8 alkyl, C5-C12 aryl or C5-C20 arylalkyl, or a heteroform of one of these; or is any other substituent suitable for an alkyl group; and wherein two Y or Y′ groups on the same ring can cyclize to form a 3-6 membered ring that can be saturated, unsaturated or aromatic, and which ring may include a heteroatom selected from O, S and N as a ring member and may be substituted; each W and W′ independently represents C═O, C═S, or an optionally substituted C 2 -C 6 alkylene or C 2 -C 6 heteroalkylene; or W can be a bond where X comprises an optionally substituted C5-C6 aryl or heteroaryl ring; and/or W′ can be a bond where X′ comprises an optionally substituted C5-C6 or heteroaryl ring; each X and X′ independently represents an optionally substituted C5-C20 ring system comprising at least one aromatic ring and up to four heteroatoms selected from N, O and S, as a ring member, and can represent either a single 5-15 membered cyclic group or two 5-10 membered cyclic groups that are both attached to the same atom of W or W′, provided that each X and X′ comprises at least one aryl or heteroaryl ring; each Q and Q′ independently represents —CH 2 —, —CH(OR)—, —CH(R)—, —(CH 2 ) r D-, —CH(R)D-, or —CR═CR— or —C≡C—, wherein r is 1-4, each D is independently O, NR, or S, and wherein each R is independently H, or optionally substituted C 1 -C 8 alkyl or optionally substituted C 1 -C 8 heteroalkyl; or one or both of Q and Q′ can be a bond where L comprises a ring; each n and n′ is independently 0-3; each m and m′ is independently 0-4; each R 1 and R 1′ is independently H or optionally substituted C1-C4 alkyl; each Z and Z′ is independently an optionally substituted C1-C6 aminoalkyl; and L represents a linker that is a C2-C20 hydrocarbyl group, optionally containing from 1-6 heteroatoms selected from N, O and S, which linker is 2 to 10 atoms in length when counted along the shortest path between Q and Q′, and which may be optionally substituted; with the proviso that L does not comprise a disulfide bond.