Patent ID: 7049310

Claim:
A compound according to formula (I): wherein: R 1 is H, C 1-4 alkyl, —C 0-6 alkyl-Ar, —(CH 2 ) 1-3 N(R′) 2 , or —(CH 2 ) 1-3 OR; R 2 is H, C 1-4 alkyl or C 3-6 cycloalkyl; R 3 is or R 4 is H or C 1-4 alkyl; indicates that one of the two designated bonds is a double bond and the other is a single bond; R 5 is CH 2 when the bond to which it is attached is a double bond; or R 5 is H or C 1-4 alkyl when the bond to which it is attached is a single bond; R 6 is H or C 1-4 alkyl; each R 7 independently is H, C 1-6 alkyl, —C 0-6 alkyl-Ar, —(CH 2 ) 1-3 N(R′) 2 , or —(CH 2 ) 1-3 OR′; R 8 is H or C 1-4 alkyl; R 9 and R 9 ′ independently are H or C 1-4 alkyl; R 10 is C 1-4 alkyl, N(R′) 2 , NHC(O)R′, NHCH 2 C(O)R′ or NHC(O)CH═CHR′; Y* is N(R′) 2 , NHC(O)R′, NHCH 2 C(O)R′ or NHC(O)CH═CHR′; each X independently is H, C 1-4 alkyl, CH 2 OH, OR′, SR′CN, N(R′) 2 , CH 2 N(R′) 2 , NO 2 , CF 3 , CO 2 R′, CON(R′) 2 , COR′, NR′C(O)R′, F, Cl, Br, I or —S(O) r CF 3 ; X* is —(CH 2 ) 1-3 C(O)N(R′)—(CH 2 ) 1-3 —Ar or —(CH 2 ) 1-3 C(O)N(R′)—(CH 2 ) 1-3 -Het; W is S or O; Q is H or C 1-4 alkyl; each R′ independently is H, C 1-6 alkyl, —CO 0-6 alkyl-Ar or —C 0-6 alkyl-Het; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.