Patent ID: 6897198

Claim:
A method for preventing arteriosclerotic phenomena related to hyperlipidemia, comprising administering to a patient in need thereof a combination, comprising at least one compound of formula I wherein: R 1 is phenyl or heteroaryl, wherein the aromatic or heteroaromatic ring is unsubstituted, or is mono- to trisubstituted by fluorine, chlorine, bromine, iodine, —OH, —CF 3 , —NO 2 , —CN, —(C 1 -C 8 )-alkoxy, —(C 1 -C 8 )-alkyl, —NH 2 , —NH—R 9 , —N(R 9 )R 10 , —CHO, —COOH, —COOR 11 , —(C═O)—R 12 , —(C 1 -C 6 )-alkyl-OH, -(C 1 -C 6 )-alkyl(—OH)-phenyl, —(C 1 -C 6 )-alkyl-CF 3 , —(C 1 -C 6 )-alkyl-NO 2 , —(C 1 -C 6 )-alkyl-CN, —(C 1 -C 6 )-alkyl-NH 2 , —(C 1 -C 6 )-alkyl-NH—R 9 , —(C 1 -C 6 )-alkyl-N(R 9 )R 10 , —(C 1 -C 6 )-alkyl-CHO, —(C 1 -C 6 )-alkyl-COOH, —(C 1 -C 6 )-alkyl-COOR 11 , —(C 1 -C 6 )-alkyl-(C═O)—R 12 , —O—(C 1 -C 6 )-alkyl-OH, —O—(C 1 -C 6 )-alkyl-CF 3 , —O—(C 1 -C 6 )-alkyl-NO 2 , —O—(C 1 -C 6 )-alkyl-CN, —O—(C 1 -C 6 )-alkyl-NH 2 , —O—(C 1 -C 6 )-alkyl-NH—R 9 , —O—(C 1 -C 6 )-alkyl-N(R 9 )R 10 , —O—(C 1 -C 6 )-alkyl-CHO, —O—(C 1 -C 6 )-alkyl-COOH, —O—(C 1 -C 6 )-alkyl-COOR 11 , —O—(C 1 -C 6 )-alkyl-(C═O)—R 12 , —N—SO 3 H, —SO 2 —CH 3 , —O—(C 1 -C 6 )-alkyl-O—(C 1 -C 6 )-alkyl-phenyl, —(C 1 -C 6 )-alkylthio, or pyridyl, wherein one or more hydrogen(s) in the alkyl radicals is optionally replaced by fluorine, and wherein phenyl and pyridyl are unsubstituted or monosubstituted by methyl, methoxy, or halogen; R 2 is H, —OH, —CH 2 OH, —OMe, CHO, or —NH 2 ; R 3 is a sugar residue, disugar residue, trisugar residue, tetrasugar residue, wherein the sugar residue, disugar residue, trisugar residue or tetrasugar residue is unsubstituted or is mono- or polysubstituted by a sugar protective group, HO—SO 2 , or (HO) 2 —PO; R 4 is H, methyl, F, or —OMe; R 9 to R 12 each independently of one another is H or —(C 1 -C 8 )-alkyl; Z is —NH—(C 0 -C 16 )-alkyl-C═O—, —O—(C 0 -C 16 )-alkyl-C═O—, —(C═O) m —(C 1 -C 16 )-alkyl-(C═O) n , an amino acid residue, a diamino acid residue, wherein the amino acid residue or diamino acid residue is unsubstituted, or mono- or polysubstituted by an amino acid protective group, or a covalent bond; n , is 0 or 1; m is 0 or 1; or a pharmaceutically tolerated salt, or a physiologically functional derivative thereof, and at least one statin.