Patent ID: 8912330

Claim:
A compound, tautomer or pharmaceutically acceptable salt of Formula 1: wherein Ring A is selected from: Ring B is a 5-membered heteroaryl ring comprising carbon atoms and 1 to 3 nitrogen atoms; L 1 is CR 4 R 5 or a bond; X is O or NR 4 ; Ring C is an aryl, a 3- to 8-membered carbocyclyl or a 5-, 6- or 7- membered heterocyclic or heteroaryl ring comprising carbon atoms and 1-4 heteroatoms independently selected from O, N, P(O) and S(O) r ; Ring D is an aryl or a 5- or 6-membered heteroaryl ring comprising carbon atoms and 1 to 4 heteroatoms independently selected from O, N and S; R a and R d are independently selected from the group consisting of halo, —CN, —NO 2 , —R 1 , —OR 2 , —O —NR 1 R 2 , —NR 1 R 2 , —NR 1 —NR 1 R 2 , —NR 1 —OR— 2 , —C(O)YR 2 , —OC(O)YR 2 , —NR 1 C(O)YR 2 , —SC(O)YR 2 , —NR 1 C(═S)YR 2 , —OC(═S)YR 2 , —C(═S)YR 2 , —YC(═NR 1 )YR 2 , —YC(═N—OR 1 )YR 2 , —YC(═N—NR 1 R 2 )YR 2 , —YP(═O)(YR 3 )(YR 3 ), —Si(R 3 ) 3 , —NR 1 SO 2 R 2 , —S(O) r R 2 , —SO 2 NR 1 R 2 and —NR 1 SO 2 NR 1 R 2 ; R c is R a or ═O or ═S; or alternatively two adjacent R a moieties, two adjacent R c moieties or two adjacent R d moieties can form with the atoms to which they are attached a 5-, 6- or 7-membered saturated, partially saturated or unsaturated ring, optionally substituted; and which contains 0 -4 heteroatoms selected from N,O, P(O) and S(O) r ; r is 0, 1 or 2; n is 0, 1 or 2; p is 0, 1,2,3,4 or 5; s is 0, 1,2,3,4 or 5; each occurrence of Y is independently a bond, —O —, —S— or —NR 1 —; each occurrence of R 1 and R 2 is independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclic and heteroaryl; each occurrence of R 3 is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclic and heteroaryl; R 4 and R 5 are independently selected from H or a C 1-6 alkyl; alternatively, each NR 1 R 2 moiety may be a 5-, 6- or 7-membered saturated, partially saturated or unsaturated ring, which can be optionally substituted and which contains 0-3 additional heteroatoms selected from N, O,P(O) and S(O) r ; and each of the foregoing alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl and heterocyclic moiety is optionally substituted.