Patent ID: 8099245

Claim:
A method of identifying a candidate substance which can bind to Trypanosoma cruzi proline racemase (TcPRAC), said method comprising: providing a computer containing the data of Table 2 converted into a three-dimensional model of TcPRAC by the computer; fitting a three-dimensional model of a candidate substance into an active site of the three-dimensional model of TcPRAC on the computer, wherein the active site comprises amino acids Leu127, Cys130, Gly131, His132, Phe290, Asp296, Cys300, Gly301, and Thr302 having the atomic coordinates of Table 2; determining whether the three-dimensional model of the candidate substance interacts with Cys130 of the three-dimensional model of TcPRAC; and selecting a candidate substance based on whether it interacts with Cys130 in the active site of the model of TcPRAC.