Patent ID: 7354585

Claim:
A method of treating a mammal suffering from a coagulapathic or thrombotic disorder comprising administering a therapeutically effective amount of a composition comprising an isolated antibody, antigen binding fragment thereof, or polypeptide comprising such an antigen binding fragment which: (a) specifically binds a factor IX/IXa domain; and (b) comprises a heavy chain and a light chain variable region further wherein: (1) the heavy chain variable region comprises a CDR1 which is SEQ ID NO:10, and CDR2 and CDR3 which are selected from the groups consisting of: (i) SEQ ID NO:11 and SEQ ID NO:12, respectively; (ii) SEQ ID NO:16 and SEQ ID NO:17, respectively; (iii) SEQ ID NO:18 and SEQ ID NO:19, respectively; (iv) SEQ ID NO:20 and SEQ ID NO:12, respectively; and (2) the light chain variable region comprises a CDR1 which is SEQ ID NO:13, CDR2 which is SEQ ID NO:14 and CDR3 which is SEQ ID NO:15.