Patent ID: 7414036

Claim:
A compound having a formula: wherein D is N or CH; E is O, S or CH 2 ; X 1 is a group of the formula —CR 20 R 21 -CYCLE, where R 20 and R 21 are the same or different and are H, F or CH 3 ; CYCLE is a bicyclic ring of the formula V: where G is N, CH, CF, CCH 3 or CCF 3 , M is H, Y is —O— or —N═, and Z is —N═ when Y is O, or is O when Y is —N═; R 5 is H, CH 3 , I, Br, Cl, CF 3 , OH or NH 2 ; and R 8 is H, —NR 9 R 10 —CHR 9 R 10 or —N═CR 9 R 10 , where R 9 and R 10 are the same or different and are hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkenyl or C 1 -C 4 alkoxyalkyl X 2 is mono-N— or di-N,N-(C 1 -C 4 )alkylaminocarbonyl, mono-N— or di-N,N-(C 3 -C 5 )cycloalkyl-aminocarbonyl or N—(C 1 -C 4 )alkyl-N—(C 3 -C 5 )cycloalkylamino-carbonyl; X 3 is OH or NH2; X 4 is OH; X 5 is H, halogen, (C 1 -C 10 )alkyl, trifluoromethyl (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, or either of the latter two groups optionally being terminally substituted by an aryl or heteroaryl group and, when having a terminal methyl group, optionally further terminally substituted by hydroxy, or a pharmaceutically acceptable salt or prodrug thereof or a pharmaceutically acceptable salt of such a prodrug.