Patent ID: 6881754

Claim:
A compound of general formula wherein D represents CH 2 or CH 2 CH 2 ; E represents C(O)NH or NHC(O); R 1 and R 2 each independently represent hydrogen, halogen, amino, nitro, C 1 -C 6 alkyl or trifluoromethyl, but R 1 and R 2 may not both simultaneously represent hydrogen; R 3 represents a group of formula R 4 represents a C 1 -C 6 alkyl group; X represents an oxygen or sulphur atom or a group NR 13 , SO or SO 2 ; R 5 represents hydrogen, or R 5 represents C 1 -C 6 alkyl or C 2 -C 6 alkenyl, each of which may be optionally substituted by at least one substituent selected from halogen, hydroxyl, (di)—C 1 -C 6 —alkylamino, —Y—R 6 , and a 5- or 6-membered heteroaromatic ring comprising from 1 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur which heteroaromatic ring may itself be optionally substituted by at least one substituent selected from halogen, hydroxyl and C 1 -C 6 alkyl; Y represents an oxygen or sulphur atom or a group NH, SO or SO 2 ; R 6 represents a group —R 7 Z where R 7 represents a C 2 -C 6 alkyl group and Z represents an —OH, —CO 2 H, —NR 8 R 9 , —C(O)NR 10 R 11 or —N(R 12 )C(O)—C 1 -C 6 alkyl group, and, in the case where Y represents an oxygen or sulphur atom or a group NH, R 6 additionally represents hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl, —C(O)NR 14 R 15 , —CH 2 OC(O)R 16 , —CH 2 OC(O)OR 17 or —C(O)OCH 2 OR 18 ; R 8 , R 9 , R 10 , R 11 and R 12 each independently represent a hydrogen atom or a C 1 -C 6 alkyl group; R 13 represents hydrogen, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkylmethyl, or R 13 represents a C 1 -C 6 alkyl group optionally substituted by at least one substituent selected from hydroxyl and C 1 -C 6 alkoxy; and R 14 , R 15 , R 16 , R 17 and R 18 each independently represent a C 1 -C 6 alkyl group; with the proviso that when E is C(O)NH, X is O, NH or N(C 1 -C 6 alkyl), then R 5 is other than an unsubstituted C 1 -C 6 alkyl group; or a pharmaceutically acceptable salt or solvate thereof.