Patent ID: 8758748

Claim:
A method for reducing side effects of a VEGF-inhibiting anti-angiogenic agent in a therapy for inhibiting undesired angiogenesis, said method comprising decreasing, in said therapy, the effective amount of said VEGF-inhibiting anti-angiogenic agent and adding a PlGF-neutralizing agent, such combined therapy reducing said side effects, said PlGF-neutralizing agent being an antibody comprising a variable heavy chain sequence of which the sequence of the CDR1, CDR2, and CDR3 region corresponds to the sequence of SEQ ID NO: 17, 18, and 19, respectively, and comprising a variable light chain sequence of which the sequence of the CDR1, CDR2, and CDR3 region corresponds to the sequence of SEQ ID NO: 20, 21, and 22, respectively.