Patent ID: 7387623

Claim:
An article of manufacture comprising a vial having (a) a first chamber that is substantially filled with a parenterally deliverable aqueous suspension that comprises (i) an aqueous medium; (ii) a drug in solid particulate form in a therapeutically effective amount suspended in the medium; and (iii) one or more wetting and/or suspending agents in an amount effective to provide controlled flocculation of the drug, at least one ingredient of the formulation being susceptible to oxidative degradation; (b) a second chamber that is substantially empty but for a gaseous medium; (c) a septum separating the first and second chambers and impermeable to the gaseous medium; and (d) actuating means effective to bring the aqueous suspension and the gaseous medium into contact by breach of the septum such that the gaseous medium acts as an effective headspace for agitation of the formulation.