Patent ID: 7989628

Claim:
A compound of formula (I) wherein Z is a bond, —CH 2 —, or —CHCH 3 —; R 1 is alkyl, hydroxyalkyl, haloalkyl, aminoalkyl, cyanoalkyl, cycloalkyl, allyl, -alkylene-C(O)Oalkyl, -alkylene-C(O)NR i R ii , —C(N—R iii )NR iv R v , —C(═N—R iii )-cycloalkyl, —C(═N—R iii )-alkyl, —O-alkyl, —O-cycloalkyl, —O-alkylene-O-alkyl, —O-alkylene-S(O) x -alkyl, or —NR a R b , wherein R a and R b are each independently H, alkyl, cycloalkyl, -alkylene-cycloalkyl, allyl, -alkylene-S(O) x -alkyl, —S(O) 2 NR vi R vii , —S(O) 2 -alkyl, —S(O) 2 -cycloalkyl, -alkylene-NR viii R ix , -alkylene-O-alkyl, —C(O)-cycloalkyl, —C(O)alkyl, —C(O)-alkylene-heterocycloalkyl, —C(O)-heterocycloalkyl, —C(O)NR vi R vii , —C(O)-alkylene-NR viii R ix , —C(O)-alkylene-O-alkyl, or heterocycloalkyl; Ar 1 is phenyl or 5- to 10-membered mono- or bicyclic heteroaryl, each unsubstituted or substituted with one or more alkyl, cycloalkyl, alkoxy, haloalkoxy, haloalkyl, halo, OH, CN, NH 2 , NO 2 , or having two substituents in the ortho-position that form a bridge anellated to the aromatic ring, wherein the bridge is selected from —O—CH 2 CH 2 O—, —O—CHCH 3 CH 2 —, and —O—C(CH 3 ) 2 CH 2 —, and wherein phenyl is not substituted with halo in para-position; R i , R ii , R vi , R vii , R viii and R ix are each independently H, alkyl, cycloalkyl, or -alkylene-N(alkyl) 2 ; R iii , R iv , and R v are each independently H, OH or alkoxy; x is 0, 1 or 2; and heterocycloalkyl is unsubstituted or substituted with one or more oxo, alkyl, halo, haloalkyl, haloalkoxy, alkoxy, hydroxy, hydroxyalkyl, or CN, or a pharmaceutically acceptable salt thereof.