Patent ID: 7374781

Claim:
A capsule for sustained release of drugs including a combination of acetaminophen of from 100 mg to 1,000 mg and tramadol or its salts of from 15 mg to 150 mg comprising: 1) an immediate release portion comprising 25%-75% of the total effective amount of the acetaminophen and tramadol in the form selected from pellets, beads, granules and mini-tablets; 2) a sustained release portion comprising: a. 25%-75% of the total effective amount of the acetaminophen and tramadol in the form selected from pellets, beads, granules and mini-tablets; and b. a gelling polymer in an amount by weight of the capsule of 6% to 50% and; 3) the capsule releases 25%-60% of the acetaminophen and the tramadol in the first hour in a simulated gastric fluid dissolution media, 50%-90% of the acetaminophen and the tramadol in the first four hours and not less than 80% of the acetaminophen and the tramadol in the first 12 hours in a simulated intestinal fluid dissolution media using USP dissolution method II at 50 rpm.