Patent ID: 6994977

Claim:
A method of identifying an inhibitor of a human C—C chemokine receptor 3 comprising: a) combining a compound to be tested, a host cell expressing a recombinant protein comprising a C—C chemokine receptor 3 polypeptide, and a ligand of said C—C chemokine receptor 3 under conditions suitable for binding of ligand to said C—C chemokine receptor 3 polypeptide, wherein said C—C chemokine receptor 3 polypeptide has at least 90% amino acid sequence identity with SEQ ID NO:2 or SEQ ID NO:6 and binds RANTES and/or MCP-3; and b) monitoring formation of a complex between said C—C chemokine receptor 3 polypeptide and said ligand; wherein formation of a complex is monitored by detecting or measuring a signalling activity or cellular response upon binding of said ligand to said C—C chemokine receptor 3 polypeptide, and inhibition of complex formation by the compound is indicative that the compound is an inhibitor.