Patent ID: 7375099

Claim:
A compound of formula wherein L is a bond, —(CH 2 ) m —, —CH(CH 3 )—, or is R 1 and R 1′ are the same or different and are hydrogen, lower alkyl, halogen, benzyl or lower alkenyl; each R 2 is independently selected from the group consisting of hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy and trifluoromethyl; R 3 is phenyl or benzyl, each of which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen and cyano, or is lower alkyl, two hydrogen atoms, (CH 2 ) m —S-lower alkyl, (CH 2 ) m -cycloalkyl, (CH 2 ) m —OH, CH 2 OCH 2 -phenyl, R 4 is lower alkoxy, mono- or dialkyl amino, N(CH 3 )(CH 2 ) m —C≡CH, or is a mono-, di or tricyclic group, unsubstituted or substituted by R 5 to R 10 , and which groups can be linked by —N(CH 3 )(CH 2 ) o , to the —C(O)-group in formula IB, selected from the group consisting of wherein each R 5 is independently selected from the group consisting of hydrogen, halogen, lower alkyl and —(CH 2 ) m OH; R 6 hydrogen, halogen or lower alkoxy; R 7 is hydrogen or —CH 2 OCH 3 ; R 8 is hydrogen or halogen; R 9 is hydrogen, lower alkoxy, lower alkyl or amino; each R 10 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, lower cycloalkyl, halogen, hydroxy, ═O, amino, nitro, —CH 2 CN, m is 1 or 2; n is 1, 2 or 3; is selected from the group consisting of wherein X is —CH 2 , —S(O) 2 or —C(O)—; R 11 is hydrogen or lower alkyl; R 12 is hydrogen or halogen; R 13 is hydrogen, CN, hydroxy, —C(O)NH 2 , R 14 is hydrogen, lower alkyl, —(CH 2 ) 2 OH or —(CH 2 ) 2 CN; or a pharmaceutically acceptable acid addition salt thereof.