Patent ID: 8853409

Claim:
A compound of general Formula I or a salt thereof, wherein: R 13 is a polyhydroxy-(2-6C) alkyl, methoxy(polyhydroxy-(3-6C)alkyl) or polyhydroxy-(5-6C)cycloalkyl; L is O or S; D 2 is N or CH; R 2 is Ar 1 , hetAr 1 , hetAr 2 , or hetAr 3 ; Ar 1 is phenyl or naphthyl, each of which is optionally substituted with one or more groups independently selected from (1-6C)alkyl, F, Br, CF 3 , OH, CN, SO 2 Me, C(═O)NH(1-3C alkyl)N(alkyl) 2 and C(═O)NH(1-3C alkyl)hetCyc l ; hetAr 1 is a 5-6 membered heteroaryl group having 1-3 ring nitrogen atoms and optionally substituted with one or more groups independently selected from (1-6C alkyl), Cl, CF 3 and (1-6C alkyl)OH; hetAr 2 is a partially unsaturated 5,6 or 6,6 bicyclic heteroaryl ring system having 1-2 ring nitrogen atoms and optionally having a ring oxygen atom; hetAr 3 is a 9-10 membered bicyclic heteroaryl ring having 1-3 ring nitrogen atoms; R 3 is Cl, Br, CF 3 , aryl, hetAr a , SR 6 or OR 6 ; hetAr a is a 6-membered heteroaryl having 1-2 ring nitrogen atoms; R 6 is Ar 2 , hetAr 4 , (1-6C alkyl), -(1-6C alkyl)OH, polyhydroxy(1-6C alkyl), —CH(R 9 )—Ar 3 , —CH(R 10 )-hetAr 5 , hetAr 6 , (5-6C)cycloalkyl substituted with 1 to 4 OH, (1-3 C alkoxy)(1-6C alkyl), or cyclopropyl(1-6C alkyl); Ar 2 is phenyl optionally substituted with one or more groups independently selected from (1-6C)alkyl, F, Br, Cl, CF 3 , CN, OH, O-(1-6C alkyl), C(═O)OH, C(═O)O(1-6C alkyl), C(═O)NH(1-3C alkyl)N(1-3Calkyl) 2 and C(═O)NH(1-3C alkyl)hetCyc 2 ; hetAr 4 is a 5-6 membered heteroaryl ring having 1-3 nitrogen atoms and optionally substituted with one or more groups independently selected from (1-6C)alkyl, F, Br, Cl, CF 3 , CN, OH, O-(1-6C alkyl), C(═O)OH, C(═O)O(1-6C alkyl), C(═O)NH(1-3C alkyl)N(1-3Calkyl) 2 and C(═O)NH(1-3C alkyl)hetCyc 2 ; Ar 3 is phenyl optionally substituted with one or more groups independently selected from F, Cl, Br, and (1-6C)alkyl; hetAr 5 is a 5-6-membered heteroaryl having 1-2 ring nitrogen atoms; hetAr 6 is a 9-10 membered bicyclic heteroaromatic ring having 2-3 heteroatoms independently selected from N, S and O (provided the ring does not contain an O—O bond) which is optionally substituted with one or more groups independently selected from (1-6C)alkyl, F, Br, Cl, CF 3 , CN, OH, —O-(1-6C alkyl), C(═O)OH, C(═O)O(1-6C alkyl) and C(═O)NH(1-3C alkyl)N(1-3Calkyl) 2 ; R 9 and R 10 are independently hydrogen, (1-6C)alkyl, (1-6C)alkylOH, or CF 3 ; and hetCyc 1 and hetCyc 2 are independently a 5-7 membered heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O.