Patent ID: 7323483

Claim:
A process comprising reacting a compound of formula (2): wherein: R 1 , R 2 , R 3 , and R 4 are each, independently, hydrogen, alkyl of 1 to 3 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, —CH 2 cycloalkyl of 4 to 6 carbon atoms, alkanoyl of 2 to 4 carbon atoms, halogen, hydroxyl, aryl of 6 to 14 carbon atoms optionally substituted with 1 to 3 R 8 groups, perfluoroalkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, amino, alkylamino of 1 to 3 carbon atoms, dialkylamino of 1 to 3 carbon atoms, or perfluoroalkoxy of 1 to 3 carbon atoms; R 5 is hydrogen, alkyl of 1 to 6 carbon atoms, perfluoroalkyl of 1 to 6 carbon atoms, aryl of 6 to 14 carbon atoms optionally substituted with 1 to 3 R 8 groups, alkanoyl of 2 to 7 carbon atoms, or aroyl of 7 to 15 carbon atoms optionally substituted with 1 to 3 R 8 groups; R 6 is hydrogen, alkyl of 1 to 6 carbon atoms, alkylaryl of 8 to 20 carbon atoms, benzyl optionally substituted with 1 to 3 R 8 groups, alkanoyl of 2 to 7 carbon atoms, or aroyl of 7 to 15 carbon atoms optionally substituted with 1 to 3 R 8 groups; and R 8 is hydrogen, alkyl of 1 to 3 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, —CH 2 cycloalkyl of 4 to 6 carbon atoms, alkanoyl of 2 to 4 carbon atoms, halogen, hydroxy, perfluoroalkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, amino, alkylamino of 1 to 3 carbon atoms, dialkylamino of 1 to 3 carbon atoms, or perfluoroalkoxy of 1 to 3 carbon atoms; with a compound of formula (3): wherein X is a leaving group; R 7 is hydrogen, alkyl of 1 to 6 carbon atoms, alkylaryl of 7 to 20 carbon atoms, or aryl of 6 to 14 carbon atoms optionally substituted with 1 to 3 R 8 groups; and n is an integer from 0 to 6; and an inorganic or organic base, to produce a compound of formula (1): or a pharmaceutically acceptable salt thereof.