Patent ID: 8193310

Claim:
A compound having a plurality of alpha helical cyclic pentapeptide sequences, which is represented by formula (IV): wherein each Xaa is independently selected from any amino acid residue; R 1 is selected from H, an N-terminal capping group, a peptide of 1 to 5 amino acid residues optionally capped by an N-terminal capping group, a non-peptidic group or a group that mimics an amino acid side chain; R 2 is selected from H, a C-terminal capping group, a peptide of 1 to 5 amino acids optionally capped by a C-terminal capping group, a group that mimics an amino acid side chain or a group that activates the terminal carboxylic acid carbonyl group to nucleophilic substitution; each R9 and R0 are independently selected from H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cylcoalkyl, C 5 -C 10 cycloalkenyl, —OH, —OC 1 -C 10 alkyl, —NH 2 , —NH(C 1 -C 10 alkyl), —N(C 1 -C 10 alkyl) 2 , C 6 -C 10 aryl, C 3 -C 10 heterocyclyl, C 5 -C 10 heteroaryl and halo; L is selected from —NH—C(O)—, —C(O)—NH—, —S—S—, —CH(OH)CH 2 —, CH 2 CH(OH)—, —CH═CH—, —CH 2 —CH 2 —, —NH—CH 2 — —CH 2 —NH—, —CH 2 —S—, —S—CH 2 —, —C(O)—CH 2 —, —CH 2 —C(O)—, —S(O) t —NH—, —NH—S(O) t —, CH 2 —P(═O)(OH)— and —P(═O)(OH)—CH 2 —; m is 4, n is 1, t is 0, 1 or 2, and p is an integer from 2 to 4.