Patent ID: 8710209

Claim:
A double stranded nucleic acid molecule having a structure (A2) set forth below: wherein each of N 2 , N and N′ is independently an unmodified or modified ribonucleotide, or an unconventional moiety; wherein each of (N)x and (N′)y is an oligonucleotide in which each consecutive N or N′ is joined to the adjacent N or N′ by a covalent bond; wherein each of x and y is 18; wherein the sequence of (N′)y has complementarity to the sequence of (N)x and the sequence of (N)x has complementarity to a consecutive sequence in a mRNA encoding hsp47; wherein N 1 is covalently bound to (N)x and is mismatched to the mRNA encoding hsp47; or is a complementary DNA moiety to the mRNA encoding hsp47; wherein N 1 is a moiety selected from natural or modified uridine or deoxyribouridine; wherein z″ may be present or absent, but if present is a capping moiety covalently attached at the 5′ terminus of N 2 —(N′)y; wherein each of Z and Z′ is independently present or absent, but if present is independently 1-5 consecutive nucleotides, consecutive non-nucleotide moieties or a combination thereof covalently attached at the 3′ terminus of the strand in which it is present; and wherein the sense strand and the antisense strand comprise the oligonucleotides described as SERPINH1 — 2 (SEQ ID NOS: 60 and 127).