Patent ID: 7026348

Claim:
An indole compound represented by the formula (I), or a pharmaceutically acceptable salt, or solvate thereof; wherein; R 1 is selected from groups (a), (b) and (c) wherein; (a) is C 7 -C 20 alkyl, C 7 -C 20 haloalkyl, C 7 -C 20 alkenyl, C 7 -C 20 alkynyl, carbocyclic radical, or (b) is a member of (a) substituted with one or more independently selected non-interfering substituents; or (c) is the group -(L 1 )-R 11 ; where, -(L 1 )- is a divalent linking group selected from —CH 2 — or —CH 2 CH 2 — and R 11 is a group selected from (a) or (b); R 2 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, O(—C 1 -C 3 alkyl), —S—(C 1 -C 3 alkyl, C 3 -C 4 cycloalkyl, CF 3 , halo, NO 2 , CN and —SO 3 ; R 3 is -(L 3 )- Z, where -(L 3 )- is a divalent linker group selected from a bond or a divalent group selected from: and Z is selected from acetamide, thioacetamide, glyoxylamide, thioglyoxylamide, hydrazide or thiohydrazide groups represented by the formulae, where R 31 and R 32 are independently selected from hydrogen, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, and C 3 -C 4 cycloalkyl, and X is oxygen or sulfur; R 4 and R 5 each independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 7 -C 12 aralkyl, C 7 -C 12 alkaryl, C 3 -C 8 cycloalkyl, phenyl, totuyl and C 1 -C 8 alkoxy or the group, -(L a )-(acylsulfonamide group), where -(L a )-, is a divalent linker having a linker length of 1 to 8; provided that at least one of R 4 and R 5 must be the group, -(L a )-(acylsulfonamide group); and R 6 and R 7 are each independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 7 -C 12 aralkyl, C 7 -C 12 alkaryl, C 3 -C 8 cycloalkyl, phenyl, totuyl and C 1 -C 8 alkoxy, carbocyclic radical, carbocyclic radical substituted with C 1 -C 8 alkyl, C 2 -C 8 alkenyl and C 7 -C 12 alkylaryl.