Patent ID: 8592444

Claim:
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein: the dotted line is an optional additional bond; n is zero or 1; R 1 is hydrogen; C 1 -C 4 alkyl; C 1 -C 4 alkyl substituted by phenyl or phenyl substituted by halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, amino, C 1 -C 4 alkylamino or phenyl; C 1 -C 4 alkyl substituted by 2-phenyl-thiazolyl, pyridyl, indolyl, quinolyl, or indolyl substituted by halogen or C 1 -C 4 alkyl; (CO)R 3 ; (SO 2 )R 4 ; cyclopentyl; phenyl; or pyrimidinyl; R 2 is phenyl or (CO)NH-phenyl; X is oxygen or NH; Y is a bond; CHR 7 ; NH; N—C 1 -C 4 alkyl; or N—C 1 -C 4 alkyl substituted by phenyl; Z is CR 9 R 10 ; C═O; C═NOH; C═NO—C 1 -C 4 alkyl; or C═NO—C 1 -C 4 alkyl substituted by phenyl; R 3 is C 1 -C 4 alkyl; phenyl; O—C 1 -C 4 alkyl; NH—C 1 -C 4 alkyl; NH—C 1 -C 4 alkyl substituted by phenyl; or NH-phenyl; R 4 is C 1 -C 4 alkyl or phenyl; R 7 is hydrogen; or is absent, when said additional bond is present; R 9 is hydrogen; or is absent, when said additional bond is present; R 10 is hydrogen; hydroxyl; or C 1 -C 4 acylamino; provided that when said additional bond is present, then Y and Z are CH.