Patent ID: 7569341

Claim:
A method for forming a nucleic acid-directed immobilization array of supramolecular bioconjugates comprising the steps of: a) attaching a first nucleic acid to a support in a regiospecific manner; b) providing at least a second nucleic acid complementary to a sequence within said first nucleic acid, wherein said second nucleic acid is coupled to a bioreactive agent, wherein said second bioreactive agent is a non-nucleic acid bioreactive agent and contains a separate binding moiety that is selected to further react with a specific target; c) providing at least a third nucleic acid complementary to a sequence within said first or second nucleic acid, wherein said third nucleic acid is coupled to a bioreactive agent, wherein said third bioreactive agent is a non-nucleic acid bioreactive agent and contains a separate binding moiety that is selected to further react with a specific target; (d) hybridizing in one step said first nucleic acid to said second nucleic acid and said third nucleic acid to said first or second nucleic acid to form a supramolecular bioconjugate; and d) repeating steps (a)-(d) to form a plurality of immobilized supramolecular bioconjugates, wherein the separate binding moiety of each of said bioreactive agent is selected to further react with a specific target.