Patent ID: 7468393

Claim:
A compound of formula I: wherein: m is 0, 1, 2 or 3; n is 0, 1 or 2; t is 1 or 2; A represents a phenyl ring optionally bearing up to 2 additional substituents selected from halogen, CN, CF 3 , OR 8 , CO 2 R a , CONR a R b , NR a R b and C 1-4 alkyl which is optionally substituted with halogen, CN, CF 3 , OR a , CO 2 R a , CONR a R b or NR a R b ; W represents —CR 3 ═CR 5 , where R 3 and R 5 are selected from H, OH and F but mot more than one of R 3 and R 5 is other than H; E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms, optionally incorporating an oxygen atom to form an ether linkage and optionally comprising a hydroxy substituent; Z is selected from H, halogen, CN, nitro, CF 3 , OCF 3 , —R a , —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a R b , —NR a R b , —NR a COR b , —NR a CO 2 R b , —NR a CONR a R b , NR a SOR b , NR a SO 2 R b , CONHCOR a , NHCH 2 CO 2 R a , NHCH 2 CONR a R b , —NR a SO 2 NR a R b , —COR a , —CO 2 R a , —CONR a R b , —CH═NOR a or a five- or six-membered heteroaromatic ring optionally bearing up to 2 substituents selected from halogen, CN, CF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, amino, C 1-6 alkylamino and di(C 1-6 )alkylamino; or the moiety -E-Z may combine with an adjacent R 2 group as defined below; R a and R b independently represent H or a hydrocarbon group of up to 7 carbon atoms which is optionally substituted with up to 3 halogen atoms or with CN, OH, C 1-4 alkoxy, C 1-4 alkylthio, amino, C 1-4 alkylamino or di(C 1-4 )alkylamino; or R a and R b , when linked through a nitrogen atom, together represent a heterocyclic ring of 4, 5 or 6 members, optionally bearing up to 3 substituents selected from halogen, CN, CF 3 , oxo, OH, C 1-4 alkyl and C 1-4 alkoxy; each R 1 independently represents halogen, CN, CF 3 , OCF 3 , C 1-6 alkyl, OH, benzylthio, C 1-6 alkoxy or hydroxymethyl; and each R 2 independently represents halogen, CN, CONH 2 , C 1-4 alkyl or C 1-4 alkoxy; or an R 2 group and the moiety -E-Z when attached to adjacent ring positions may complete a fused 5- or 6-membered carbocyclic or heterocyclic ring optionally bearing up to 3 substituents selected from halogen, CN, CF 3 , oxo, R a and amino; with the proviso that when A represents the residue of a phenyl ring and W represents —CH═CH—, m is not zero and at least one R 1 represents F; or a pharmaceutically acceptable salt or hydrate thereof.