Patent ID: 8680275

Claim:
A chemical entity that is a compound of Formula (I): wherein: n is 0-1; R 1 is a member selected from the group consisting of: A) phenyl substituted or unsubstituted with one or two R a members, and substituted in the ortho position with R b ; R a is independently selected from the group consisting of: halo, —C 1-4 alkyl, and —C 1-4 alkoxy, wherein two adjacent R a members may come together to form a six membered aromatic ring; R b is a member selected from the group consisting of: a) halo, —C 1-4 alkoxy, —CF 3 , or —CF 2 CHF 2 ; b) 5-membered heteroaryl ring containing one oxygen or one sulfur members; c) 5-6 membered heteroaryl ring containing one to three nitrogen members, optionally containing one oxygen member, substituted or unsubstituted with halo, —C 1-4 alkyl, tetrahydropyran-2-yl, or —N(CH 3 ) 2 ; and d) phenyl substituted or unsubstituted with —F, or —CH 3 ; B) pyridine substituted or unsubstituted with one or two R c members and substituted with R d , wherein R d is positioned adjacent to the point of attachment by R 1 ; R c is a member independently selected from the group consisting of: —C 1-4 -alkyl, —CF 3 , and —C 1-4 alkoxy; R d is a member selected from the group consisting of: a) 5-6 membered heteroaryl ring selected from the group consisting of: 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1H-pyrazol-3-yl, and 6-methyl-pyridin-2-yl; and b) —CF 3 , —Br, or —C 1-4 alkoxy; C) 6-membered heteroaryl ring selected from the group consisting of: pyrimidin-yl or pyrazin-yl, substituted or unsubstituted with a member independently selected from —CH 3 , —OCH 3 , or phenyl; D) 5-membered heteroaryl ring selected from the group consisting of: 2-methyl-1,3-thiazol-yl, 5-methyl-isoxazol-4-yl, 2H-pyrazol-3-yl, 1H-pyrazol-4-yl, isoxazolyl, and 1,3-oxazol-4-yl, each substituted with phenyl substituted or unsubstituted with —F or —Cl; and E) 3-methylfuran-2-yl, 9H-fluorene, 9H-fluoren-9-one, 3,5′-biisoxazole, [3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazol-4-yl], or naphthyridine; R 2 is a member selected from the group consisting of: A) 6-membered heteroaryl ring containing two nitrogen members substituted or unsubstituted with one or more members independently selected from the group consisting of: halo, —C 1-4 alkyl, —C 1-4 alkoxy, —CF 3 , —NH 2 , —NHCH 3 , —N(C 1-4 -alkyl) 1-2 , —NHcyclopropyl, and phenyl; B) pyridine substituted or unsubstituted with one or two members independently selected from the group consisting of: —C 1-4 alkyl, —N(C 1-4 alkyl) 2 , and —CF 3 ; and C) quinoxalin-2-yl, benzooxazol-2-yl, or 5-chloro-1,3-benzoxazole; and pharmaceutically acceptable salts of compounds of Formula (I).