Patent ID: 8206907

Claim:
A method of detecting or prognosing acute myeloid leukemia (AML) in a test individual, said method comprising, for each of a plurality of sCD antigens, wherein at least one sCD antigen is selected from the group consisting of: sCD14, sCD30, sCD54, sCD117 and sCD130, (a) quantifying a level of expression of said sCD antigen in a serum, plasma or other body fluid sample of said test individual, and (b) comparing said level of sCD antigen quantified in step (a) to a quantified level of control sCD antigen in serum, plasma or other body fluid samples of control subjects classified as healthy (normal) subjects; and/or (c) comparing said level of sCD antigen quantified in step (a) to a quantified level of control sCD antigen in serum, plasma or other body fluid samples of control subjects classified as having AML; wherein a determination from step (b) that said level of step (a) is statistically different from said level in step (b) in said serum, plasma or other body fluid samples of control subjects classified as healthy (normal) samples of said subjects classified as healthy subjects, results in a classification of said sCD antigen expression in said test individual with that of said subjects classified as having AML; wherein a determination from steps (b) and (c) that said level of step (a) is statistically different from said level in step (c) in said serum, plasma or other body fluid samples of said subjects classified as having AML and is statistically similar to said level in step (b) in said serum, plasma or other body fluid samples of said subjects classified as healthy subjects, results in a classification of said sCD antigen expression in said test individual with that of said subjects who classified as healthy subjects, and wherein a determination from steps (b) and (c) that said level of step (a) is statistically similar to said level in step (c) in said serum, plasma or other body fluid samples of said subjects classified as having AML, and is statistically different from said level in step (b) in said serum, plasma or other body fluid samples of said subjects classified as healthy subjects, results in a classification of said sCD antigen expression in said test individual with that of said subjects classified as having AML.