Patent ID: 7439232

Claim:
A 5-thio-β-D-glucopyranoside compound of the following formula or a pharmaceutically acceptable salt thereof or a hydrate thereof: wherein B represents a heteroaryl group which may be substituted with any substituent, R 1A , R 2A , R 3A and R 4A , which may be the same or different, each represent a hydrogen atom, a C 2-10 acyl group, a C 7-10 aralkyl group, a C 2-6 alkoxycarbonyl group, a C 1-6 alkoxy-C 2-10 acyl group or a C 1-6 alkoxy-C 2-6 alkoxycarbonyl group, Q X represents N or C, X A represents —(CH 2 )n-, —CO(CH 2 )n-, —C(OH)(CH 2 )n-, —O—(CH 2 )n-, —CONH(CH 2 )n-, —NHCO(CH 2 )n- (wherein n is an integer of 0 to 3), —COCH═CH—, —S— or —NH—, provided that when Q X is N, X A represents —(CH 2 )n-, —CO(CH 2 )n-, —C(OH)(CH 2 )n-, —CONH(CH 2 )n- wherein n is an integer of 0 to 3 or —COCH═CH—, and R 5 , R 6 , R 7 , R 8 and R 9 , which may be the same or different, each represent: a hydrogen atom; a halogen atom; a hydroxyl group; a C 1-6 alkyl group which may be substituted with one or more substituents selected from the group consisting of a halogen atom and a hydroxyl group; a group represented by the formula: —(CH 2 )m′-Q′ wherein m′ represents an integer of 0 to 4, and Q′ represents a formyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a sulfonic acid group, an optionally halogen-substituted C 1-6 alkoxy group, a C 1-6 alkoxy-C 1-6 alkoxy group, a C 2-10 acyloxy group, a C 2-10 acyl group, a C 2-6 alkoxycarbonyl group, a C 1-6 alkylthio group, a C 1-6 alkylsulfinyl group, a C 1-6 alkylsulfonyl group, —NHC(═O)H, a C 2-10 acylamino group, a C 1-6 alkylsulfonylamino group, a C 1-6 alkylamino group, an N,N-di(C 1-6 alkyl)amino group, a carbamoyl group, an N—(C 1-6 alkyl)aminocarbonyl group, or an N,N-di(C 1-6 alkyl)aminocarbonyl group; or a C 3-7 cycloalkyl group, a C 3-7 cycloalkyloxy group, an aryl group, a C 7-10 aralkyl group, an aryloxy group, a C 7-10 aralkyloxy group, a C 7-10 aralkylamino group, a heteroaryl group, or a 4- to 6-membered heterocycloalkyl group, provided that each of these groups may be substituted with 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxyl group, a C 1-6 alkyl group and a C 1-6 alkoxy group.