Patent ID: 7923561

Claim:
A compound of general formula (I), wherein X is selected from the group consisting of a bond, —NR a —, —O—, —S—, —SO 2 —, —NR b —S(O) 2 —, —NR c —CH 2 —, —OCH 2 —, —CH 2 O—, —SCH 2 —, —CH 2 S—, —NR d —, —C(O)—, —CH 2 —NR c —, —CH 2 CH 2 —, —CH═CH—, —CH 2 —S(O) 2 —, —OCH 2 CH 2 —, —SCH 2 CH 2 —, —NR c CH 2 CH 2 —, —CH 2 —NR d —C(O)—, —CH 2 —NR c —CH 2 —, —C(NR k )—, —C(O)—, —NR b —S(O) 2 —NR b —, and —C(N—OR p )—; R 1 is mono- or bicyclic aryl, or mono- or bicyclic heteroaryl, each optionally substituted by one or more substituents independently selected from the group consisting of: halo, alkyl, optionally substituted by —OH or —CN, alkoxy, —S(O) 2 -alkyl, —NR e R f , —S(O) 2 —NR g R h , haloalkyl, —CH 2 —O-alkyl, —(OCH 2 CH 2 ) m —OR i , wherein m is an integer from 1 to 3, —(OCH 2 CH 2 ) m —NR q R r , wherein m is an integer from 1 to 3, —CH 2 —(N-morpholino), —CH 2 —(OCH 2 CH 2 ) m —OR j , wherein m is an integer from 1 to 3, hydroxy, cyano, nitro, and allyl; R 2 is 5- to 7-membered cycloalkyl or heterocycloalkyl, or bicyclo[2.2.1]heptyl each optionally anellated with an aromatic 5- or 6-membered carbo- or heterocycle, each ring optionally and independently substituted with one or more substituents independently selected from the group consisting of: alkoxy, hydroxy, halo, alkyl, optionally substituted by —OH or —CN, —S(O) 2 -alkyl, —NR e R f , —S(O) 2 —NR g R h , —CH 2 —O-alkyl, —(OCH 2 CH 2 ) m —OR i , wherein m is an integer from 1 to 3, —CH 2 —(OCH 2 CH 2 ) m —OR j , wherein m is an integer from 1 to 3, cyano, nitro, and allyl; R a , R b , R c , R d , R e , R f , R g , R h , R i , R j , R k , R p , R q and R r are each independently selected from the group consisting of: hydrogen, alkyl and —(CH 2 ) n -cycloalkyl, wherein n is an integer from 0 to 3; or a pharmaceutically-acceptable-acid addition salt thereof.