Patent ID: 7417144

Claim:
A compound of formula 1 d: or pharmaceutically acceptable salt thereof wherein: R 1 and R 2 are independently selected from the group consisting of: (1) hydrogen, (2) C 1-6 alkyl, (3) C 1-6 alkoxy, (4) fluoro C 1-6 alkoxy, (5) hydroxy C 1-6 alkoxy, (6) C 1-6 alkoxy C 1-6 alkoxy, (7) mono or di C 1-6 alkyl substituted amino C 1-6 alkoxy, (8) halogen, (9) cyano, (10) nitro, (11) —N(R′)—CO—(C 1-6 alkyl optionally substituted by one or more fluorine atoms) wherein R′ is hydrogen, C 1-6 alkyl or fluoro C 1-6 alkyl, (12) —N(R′)—CO—O—(C 1-6 alkyl optionally substituted by one or more fluorine atoms) wherein R′ is hydrogen, C 1-6 alkyl or fluoro C 1-6 alkyl, (13) —N(R′)—CO—N(R″) (R′″) wherein R′, R″ and R′″ are independently hydrogen, C 1-6 alkyl or fluoro C 1-6 alkyl, (14) —N(R′)—SO 2 —(C 1-6 alkyl optionally substituted by one or more fluorine atoms) wherein R′ is hydrogen, C 1-6 alkyl or fluoro C 1-6 alkyl; and (15) —SO 2 —N(R′)(R″), —C(O)—N(R′)(R″) or —N(R′)(R″) wherein R′ and R″ are independently selected from the group consisting of hydrogen, C 1-6 alkyl and fluoro C 1-6 alkyl, or alternatively, R′ and R″, together with the nitrogen atom to which they are attached, form a heterocycyl; X 1 is —C(O)—NH— or —C(O)—; —X 2 —X 3 forms phenyl or pyridyl, wherein said phenyl or pyridyl is optionally substituted by one or more halogen atoms; Y 1 is —C(O)—NH—; Y 2 is 1,4-phenylene optionally substituted by one or more halogen atoms; Y 3 is hydrogen, aryl, heteroaryl or heterocyclyl, wherein one or two carbon atoms of the aryl, heteroaryl or heterocyclyl may be optionally replaced with a carbonyl group and wherein the aryl, heteroaryl or heterocyclyl may be optionally substituted by one or more substituents indepenently selected from the group consisting of: (1) C 1-6 alkyl, (2) C 1-6 alkoxy, (3) halogen, (4) cyano, (5) nitro, (6) amino, (7) mono-C 1-6 alkyl substituted amino, (8) di-C 1-6 alkyl substituted amino (9) mono-C 1-6 alkyl substituted amino-C 1-6 alkyl, (10) di-C 1-6 alkyl substituted amino-C 1-6 alkyl, (11) —SO 2 —C 1-6 alkyl, (12) —SO 2 —NH 2 , (13) —SO 2 —NH—C 1-6 alkyl and (14) —SO 2 —N(C 1-6 alkyl) 2 .