Patent ID: 8748384

Claim:
A method of treating a neurological disease or a neural disorder comprising administering to a subject in need thereof a therapeutically effective amount of an antibody that binds to: (1) residues 7-10 (RIFR); (2) residues 14-18 (FAKNF); or (3) residues 7-10 (RIFR) and residues 14-18 (FAKNF); of a Sortilin receptor that consists of the amino acid sequence of SEQ ID NO:25, wherein: (i) said antibody inhibits binding of a pro-neurotrophin to a binding site on said Sortilin receptor, thereby treating said neurological disease or neural disorder; and (ii) said neurological disease or neural disorder is selected from the group consisting of Alzheimer's disease, Parkinson's disease, Huntington's chorea, stroke, nerve deafness, peripheral neuropathy, and Fabry's disease.