Patent ID: 8628930

Claim:
A method for detecting and treating a renal disorder in a subject, the method comprises: (i) measuring a human megalin level in a urine sample; (ii) determining the status or the degree of the renal disorder based on the human megalin level of step (i), wherein an increased level of human meglin comparing to a normal healthy subject indicates the renal disorder; and (iii) treating the subject with a suitable therapy based on the status or the degree of the renal disorder determined by step (ii), wherein the renal disorder is selected from the group consisting of diabetic nephropathy, IgA nephropathy, acute renal failure, nephritic syndrome, chronic glomerulonephritis, membranous nephropathy, ANCA-associated glomerulonephritis, lupus glomerulonephritis, Henoch-Schönlein purpura nephritis, crescentic glomerulonephritis, focal glomerulosclerosis, acute renal failure, chronic renal failure, scleroderma renal crisis, post-transplant renal disorder, and interstitial glomerulonephritis caused by Sjogren's syndrome.