Patent ID: 7157594

Claim:
A 2-amino-3-alkoxy-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: [wherein R 1 and R 2 , which may be the same or different, each represent a hydroxyl group, a C 1-10 alkoxy group, a phenoxy group, a naphthyloxy group, a C 1-6 alkoxy group which is substituted with one or two phenyl groups, a C 1-6 alkoxy-C 1-6 alkoxy group, a hydroxy-C 2-6 alkoxy group, an amino group, an amino group which is substituted with the same or different one or two C 1-6 alkyl groups, an amino group which is substituted with the same or different one or two C 1-6 alkoxy-C 1-6 alkyl groups, an amino group which is substituted with the same or different one or two hydroxy-C 2-6 alkyl groups, an amino group which is substituted with the same or different one or two C 1-6 alkoxycarbonyl-C 1-6 alkyl groups, or a native or non-native amino acid residue represented by NR 6 —CHR 7 -A-CO 2 R 8 (wherein R 6 and R 7 , which may be the same or different, each represent a hydrogen atom, a hydroxy-C 1-6 alkyl group, a hydroxycarbonyl-C 1-6 alkyl group, a C 1-10 alkyl group, a phenyl group, a phenyl-C 1-6 alkyl group, a hydroxyphenyl group, a hydroxyphenyl-C 1-6 alkyl group, a naphthyl group, a naphthyl-C 1-6 alkyl group, an aromatic heterocyclic C 1-6 alkyl group, a C 1-6 alkoxy-C 1-6 alkyl group, an amino-C 2-6 alkyl group, a guanidino-C 2-6 alkyl group, a mercapto-C 2-6 alkyl group, a C 1-6 alkylthio-C 1-6 alkyl group or an aminocarbonyl-C 1-6 alkyl group, or R 6 and R 7 may together represent a group capable of forming a methylene group, an ethylene group or a propylene group, or may together form a cyclic amino group; R 8 represents a hydrogen atom or a protecting group for a carboxyl group; and A represents a single bond, a methylene group, an ethylene group or a propylene group); R 3 represents a hydrogen atom, a C 1-10 acyl group, a C 1-6 alkoxy-C 1-6 acyl group, a hydroxy-C 2-10 acyl group, a C 1-6 alkoxycarbonyl-C 1-6 acyl group, a hydroxycarbonyl-C 1-6 acyl group, or an amino acid residue represented by R 9 —NH-A-CHR 7 —CO (wherein R 7 and A are as defined above, and R 9 represents a hydrogen atom or a protecting group for an amino group); and R 4 and R 5 , which may be the same or different, each represent a hydrogen atom, a C 1-10 alkyl group, a C 2-10 alkenyl group, a phenyl group, a naphthyl group, a 5-membered heteroaromatic ring containing one or more heteroatoms, or a phenyl group substituted with 1 to 5 substituents selected from the group consisting of a halogen atom, a C 1-10 alkyl group, a C 1-10 alkoxy group, a trifluoromethyl group, a phenyl group, a hydroxycarbonyl group, an amino group, a nitro group, a cyano group and a phenoxy group, or R 4 and R 5 may together form a cyclic structure] or a pharmaceutically acceptable salt or hydrate thereof.