Patent ID: 7122193

Claim:
A vaccine comprising an immunoretroid form of an immunologically active peptide, said immunoretroid being a derivative of said peptide which binds to an antibody or an antibody fragment to said peptide with at least an equal affinity as said peptide; wherein said immunoretroid form is a retro-inverso peptide or a retro-peptide of a peptide, wherein said immunoretroid form of said peptide has the following formula II: A—CH(R i )—NH—[CO—CH(R k )—NH] j−i —CO—CH(R j+ 1)—B (II) wherein n, which is the number of aminoacyl residues in formula II, is 20, and R i , R k , and R j+1 are side chains of the aminoacyl residues, i, j and k are whole numbers wherein 1≦i≦j<n, and if i=j, k=0; and if i<j, i+1≦k≦j; such that, where i=1 and j+1=n, A is Q and B is M; where i=1 and j+1≠n, A is Q and B is L; where i≠1 and j+1=n, A is T and B is M; and where i≠1 and j+1≠n, A is T and B is L; Q being selected from the group consisting of H—, H 2 N—, P—HN—, RR′N—, H 2 NCO—, RR′NCO—, RCO—; M being selected from the group consisting of H—, —COOH, —COOR, —CONH 2 , —CONRR′ and —NHCOR; L being —CO—NH—CH(R j+2 )—CO— . . . —NH—CH(R n )—CO—Y wherein Y is selected from the group consisting of —OH, —OR, —NH 2 , and —NRR′; and T being X—HN—CH(R 1 )—CO— . . . —NH—CH(R i−1 )CO—NH— wherein X is selected from the group consisting of H—, P—, R— and RCO—; wherein R and R′ are independently selected from the group consisting of hydrogen, C 1-25 alkyl, C 3-25 allyl, C 6-25 aryl, benzyl, 2-phenyl-ethyl, methyl-fluorenyl, glycolamide and benzhydrylglycolamide; and P is a protecting group; and and wherein said immunoretroid form is a retro-inverso peptide or a retro-peptide of a peptide selected from the group consisting of FP peptide of serotype A12 of foot-and-mouth disease virus, FL peptide of serotype A12 of foot-and-mouth disease virus, SL peptide of serotype A12 of foot-and-mouth disease virus, said vaccine further comprising a physiologically acceptable vehicle.