Patent ID: 8809342

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is phenyl substituted with halo or trifluoromethyl; or a 6-membered heteroaryl group which is optionally fused with a (C 4 -C 7 )cycloalkyl, phenyl or 5 to 6 membered heteroaryl, and wherein the optionally fused 6-membered heteroaryl group is optionally substituted with one to four substituents each independently selected from halo, —S(O) 2 —(C 1-3 )alkyl, hydroxy, —C(O)NR a R b , cyano, (C 1 -C 6 )alkyl optionally substituted with one to three fluoro, or (C 1 -C 6 )alkoxy optionally substituted with one to three fluoro; R a and R b are each independently H or (C 1 -C 3 )alkyl; R 2 is H; R 3 is —(CH 2 ) 2 CO 2 H; A 1 , A 2 , A 3 and A 4 are each independently CR 4 or N, with the proviso that two of A 1 , A 2 , A 3 and A 4 are N and the remaining are CR 4 ; R 4 at each occurrence is independently H, halo, cyano, (C 1 -C 3 )alkyl optionally substituted with one to three fluoro, or (C 1 -C 3 )alkoxy optionally substituted with one to three fluoro; L is —CH(R 5 )—X—; X is NH; R 5 is (C 1 -C 6 )alkyl which is optionally substituted with one to three fluoro, hydroxy or methoxy; (C 3 -C 7 )cycloalkyl which is optionally substituted with one to two (C 1 -C 3 )alkyl which are optionally substituted with one to three fluoro or one to two (C 1 -C 3 )alkyl and wherein one to two carbons of the (C 3 -C 7 )cycloalkyl can be replaced with a NH, N(C 1 -C 3 )alkyl, O or S; or (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl wherein the (C 3 -C 7 )cycloalkyl group of said (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl is optionally substituted with one to two (C 1 -C 3 )alkyl which are optionally substituted with one to three fluoro; B 1 , B 2 , B 3 and B 4 are each independently CR 6 or N, with the proviso that one of B 1 , B 2 , B 3 and B 4 is N and the remaining are CR 6 ; and R 6 at each occurrence is independently H, halo, (C 1 -C 3 )alkyl optionally substituted with one to three fluoro, or (C 1 -C 3 )alkoxy optionally substituted with one to three fluoro.