Patent ID: 8771379

Claim:
A method of preparing a crystal based on a compound (C), by crystal growth in solution, the method comprising: providing a crystallization system comprising: a solution (S) supersaturated with said compound (C), a crystallization chamber, in fluid communication with a saturation chamber, said saturation chamber including a source of compound (C) in the form of a feeder substance; maintaining a constant crystallization temperature (T c ) in the crystallization chamber and a constant saturation temperature (T s ) in the saturation chamber, wherein T c is different from T s and the solubility of the compound (C) in the solution (S) at the temperature T s is greater than the solubility of the compound (C) in the solution (S) at the temperature T c ; circulating solution (S) in a continuous flow circuit between the saturation chamber and the crystallization chamber, wherein the solution is circulated at a substantially constant flow rate; and carrying out the crystal growth within the crystallization chamber, while maintaining the constant crystallization temperature T c , the constant saturation temperature T s , and the substantially constant flow rate, in order to maintain a constant rate of supersaturation within the crystallization chamber during the crystal growth.