Patent ID: 7678815

Claim:
A compound of formula (I): wherein R 1 is aryl or heteroaryl, each of which is optionally substituted by one or more substituents selected from the group consisting of —OH, chloro, fluoro, bromo, cyano, C 1 -C 7 -alkyl, C 1 -C 7 -alkoxy, —O—(CO)—C 1 -C 7 -alkyl, C 3 -C 6 -cycloalkyl, and —(CH 2 ) m —R a , wherein R a is —OH, —CH 2 F, —CHF 2 , —CF 3 , C 1 -C 7 -alkoxy, C 3 -C 6 -cycloalkyl, —NH(CO)—C 1 -C 7 -alkyl, or —O—(CO)—C 1 -C 7 -alkyl; R 2 is H, C 1 -C 7 -alkyl, —(CH 2 ) m —O—C 1 -C 7 -alkyl or C 3 -C 6 -cycloalkyl; R 3 is C 1 -C 7 -alkyl; —(CH 2 ) m —R b , wherein R b is —O—C 1 -C 7 -alkyl, C 3 -C 6 -cycloalkyl, 5 or 6 membered heterocycloalkyl, aryl optionally substituted by fluoro, or heteroaryl optionally substituted by C 1 -C 7 -alkyl; —(CO)—R c , wherein R c is —O—(CH 2 ) m —C 3 -C 6 -cycloalkyl, or aryl; C 3 -C 6 -cycloalkyl; 5 or 6 membered heterocycloalkyl; aryl or heteroaryl, each of which is optionally substituted by cyano, chloro, fluoro, bromo, CF 3 , CHF 2 , C 3 -C 6 -cycloalkyl, or —O—C 1 -C 7 -alkyl; —(CO)—R d , wherein R d is C 1 -C 7 -alkyl, NH 2 , or —O—C 1 -C 7 -alkyl; —(CH 2 ) m —R e , wherein R e is OH, C 1 -C 7 -alkoxy, CHF 2 , CF 3 , NH 2 , —NH—(CO)—C 1 -C 7 -alkyl, or —NH—(CO)—O—C 1 -C 7 -alkyl; —NH—(CO)—C 1 -C 7 -alkyl; —O—CH 2 F; —O—CHF 2 ; —O—CF 3 ; —S(O) 2 —R f , wherein R f is C 1 -C 7 -alkyl, —NH 2 , —NH—C 1 -C 7 -alkyl or —N-di(C 1 -C 7 -alkyl); or heteroaryl optionally substituted by C 1 -C 7 -alkyl; R 4 is H, C 1 -C 7 -alkyl or C 1 -C 7 -alkyl-C 3 -C 6 -cycloalkyl; m is 1 to 4; or a pharmaceutically acceptable salt thereof.