Patent ID: 7390820

Claim:
A compound of Formula I wherein bond a is either a single bond or a double bond; wherein X is CH; wherein Y is NR 4 ; wherein Z is CR 5 if bond a is a double bond; wherein Z is CHR 5 if bond a is a single bond; wherein R is selected from a) substituted or unsubstituted 6-10 membered aryl, b) substituted or unsubstituted 4-6 membered heterocyclyl, c) substituted or unsubstituted 9-14 membered fused heterocyclyl, d) substituted or unsubstituted aryl-C 1-2 -alkyl, e) substituted or unsubstituted heterocyclyl-C 1-2 -alkyl, and f) lower alkyl; where substituted R is substituted with one or more substituents selected from halo, —OR 3 , —SR 3 , —SO 2 R 3 , —CO 2 R 3 , —C(O)NR 3 R 3 , —C(O)R 3 , —NR 3 R 3 , —SO 2 NR 3 R 3 , —NR 3 C(O)OR 3 , —NR 3 C(O)R 3 , optionally substituted 3-6 membered heterocyclyl, optionally substituted phenyl, alkylaminoalkoxyalkoxy, nitro, cyano, oxo, lower alkyl substituted with one or more R 2 ; wherein R 1 is selected from unsubstituted or substituted a) 6-10 membered aryl, b) 5-6 membered heterocyclyl, c) 9-14 membered fused heterocyclyl, d) cycloalkyl, e) cycloalkenyl, f) lower alkyl, and g) lower alkenyl, wherein substituted R 1 is substituted with one or more substituents independently selected from halo, —OR 3 , —SR 3 , —CO 2 R 3 , —C(O)NR 3 R 3 , —C(O)R 3 , —NR 3 R 3 , oxo, —OC(O)R 3 , —SO 2 R 3 , —SO 2 NR 3 R 3 , —NR 3 C(O)OR 3 , —NR 3 C(O)R 3 , —NR 3 C(O)NR 3 R 3 , optionally substituted cycloalkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted phenyl, cyano, aminoalkylcarbonylamino, alkylaminoalkylcarbonylamino, alkylaminoalkoxy, alkylaminoalkoxyalkoxy, nitro, and lower alkyl substituted with one or more R 2 ; wherein R 2 is selected from H, halo, —OR 3 , amino, C 1-3 -alkylamino, C 1-3 -dialkylamino, C 1-3 -alkyl, optionally substituted phenyl, optionally substituted phenyl-C 1-3 -alkyl, 4-6 membered heterocyclyl, and optionally substituted 4-6 membered heterocyclyl-C 1 -C 3 -alkyl; wherein R 3 is independently selected from H, lower alkyl, optionally substituted phenyl, optionally substituted 3-6 membered heterocyclyl, optionally substituted C 3 -C 6 -cycloalkyl, optionally substituted phenylalkyl, optionally substituted 3-6 membered heterocyclylalkyl, optionally substituted C 3 -C 6 cycloalkylalkyl and lower haloalkyl; wherein R 4 is independently selected from H, and lower alkyl; wherein R 5 is independently selected from H, —OR 3 , and lower alkyl; wherein R 5a is independently selected from H, and lower alkyl; and wherein R 6 is selected from H, halo, —OR 3 , —SR 3 , —CO 2 R 3 , —SOR 3 , —C(O)NR 3 R 3 , —C(O)R 3 , —NR 3 R 3 , —SO 2 R 3 , —SO 2 NR 3 R 3 , —NR 3 C(O)OR 3 , —NR 3 C(O)R 3 , —NR 3 C(O)NR 3 R 3 , optionally substituted cycloalkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted phenyl, cyano, nitro, lower alkyl substituted with one or more R 2 , lower alkenyl substituted with one or more R 2 and lower alkynyl substituted with one or more R 2 ; or a pharmaceutically acceptable derivative thereof.