Patent ID: 7317024

Claim:
A compound having the structure of formula (II) or a stereoisomer thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein R is NH 2 , —NHC(O)C 1-4 alkyl, or C 1-4 alkyl; R a and R b are independently selected from hydrogen, halogen, C 1-4 alkyl, cyano, nitro, amino, formyl, CO 2 alkyl, and CONR e R f ; one of R 1 and R 2 is heteroaryl; R 4 and R 5 are independently at each occurence hydroxy, alkoxy, aryloxy, cyano, nitro, NR e R f , CHO, —CO 2 alkyl, OCONR e R f , OCO t R e , OCO t -aryl, OCO t -heteroaryl, CONR e R f , CH 2 NR e R f , CO 2 H, OCSO t R e R f , CSNR e R f , NR g CO t R i , NR g CONR e R f , NR g CSNR e R f , NR g SO t R i , NR g SO 2 R i , SO 2 NR e R f , or NR g SO 2 NR e R f ; R 6 is hydrogen, S(O) t R h , or C(O) t R h ; R a and R b are independently selected from hydrogen, halogen, C 1-4 alkyl, cyano, nitro, amino, formyl, CO 2 alkyl, and CONR e R f ; R c and R d are independently H or OH; R e and R f are independently at each occurrence selected from hydrogen, aryl, alkyl, alkenyl, alkynyl, alkoxy, amino, substituted amino, alkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, heteroaryl, cycloheteroalkyl, heteroarylalkyl, cycloheteroalkylalkyl, cycloalkyl, and cycloalkylalkyl, provided R e and R f are not both alkoxy or amino; or R e and R f at each occurrence can be taken together with the nitrogen to which they are attached to form a 5-, 6- or 7-membered heteroaryl or cycloheteroalkyl ring which contains 1, 2 or 3 hetero atoms which can be N, O or S; R g , R h and R i are independently at each occurrence selected from hydrogen, aryl, alkyl, alkenyl, alkynyl, alkoxy, amino, substituted amino, alkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, heteroaryl, cycloheteroalkyl, heteroarylalkyl, cycloheteroalkylalkyl, and cycloalkyl and cycloalkylalkyl; and R 2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloalkenyl, monoalkylaminoalkyl, dialkylaminoalkyl, cycloheteroalkylalkyl, hydroxyaryl, aryloxyalkyl, alkoxyalkyl and hydroxyalkyl; r and s are independently 0, 1, 2, 3, or 4, provided r+s is ≧1; and t is 1 or 2.