Patent ID: 7144899

Claim:
A compound of the general formula, wherein u is CH or N; Q is 1) —N(R 25 )CH(R 30 )— wherein the nitrogen atom is attached to R 1 , and R 25 and R 30 are independently selected from the group consisting of hydrogen, C 3-6 cycloalkyl, and C 1-6 alkyl, or wherein the nitrogen atom is attached to R 1 , and m is 0, 1, or 2; R 1 is selected from the group consisting of wherein R 4 and R 5 are independently selected from the group consisting of hydrogen, halogen, C 14 alkoxy, C 1 alkyl, —OH, and cyano, and X is a bond, O, CH 2 , S or NH, wherein R 6 is selected from the group consisting of a) hydrogen, b) —OH, and c) —NR 19 R 20 , where R 19 and R 20 are independently selected from the group consisting of 1) hydrogen, and 2) C 1-6 alkyl, unsubstituted or substituted with one or more of —OH, —COOH, C 3-7 cycloalkyl, or COOR 17 , where R 17 is C 1-4 alkyl, 3) C 3-7 cycloalkyl, 4) C(O)OR 18 , 5) C(O)R 18 , 6) C(O)NHR 18 , 7) SO 2 R 18 , 8) C(O)NH 2 , and 9) CN, wherein R 18 is selected from the group consisting of C 1-4 alkyl, aryl, and C 3-7 cycloalkyl, and R 7 and R 8 are independently selected from the group consisting of a) hydrogen, b) —CF 3 , c) unsubstituted C 1-6 alkyl, d) a ring slected from the group consisting of wherein R 91 and R 99 are independently selected from the group consisting of 1) hydrogen, 2) halogen, 3) C 1-4 alkoxy, 4) C 1-4 alkyl, 5) hydroxy, 6) CF 3 , and 7) cyano, e) C 3-6 cycloalkyl, f) C 1-6 alkyl substituted with one of the group consisting of 1) C 3-6 cycloalkyl, 2) —COOH, 3) —OH, wherein R 9 and R 10 are independently selected from the group consisting of aa) hydrogen, bb) halogen, cc) C 1-4 alkoxy, dd) C 1-4 alkyl, ee) hydroxy, ff) CF 3 and gg) cyano, and wherein y is 0, 1 or 2, and R 35 and R 40 are independently selected from the group consisting of hydrogen and C 1-6 alkyl; R 2 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C 1-4 alkyl, 4) C 3-7 cycloalkyl, 5) CF 3 , 6) OCF 3 , 7) C 1-4 alkoxy, and 8) cyano; and R 12 is 1) a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 2 heteroatoms are N, and at most 1 of the heteroatoms is S or O, said ring being unsubstituted or substituted, at any one ring atom, with C 1-6 alkyl or halogen, or 2) a 6-membered heteroaryl ring with 1–2 nitrogen atoms, said ring being unsubstituted or substituted with with C 1-6 alkyl or halogen, or a pharmaceutically acceptable salt thereof.