Patent ID: 8377927

Claim:
A pyrroloquinolinyl-pyrrolidine-2,5-dione compound of formula IVa, IVb, Va, or Vb, or pharmaceutically acceptable salts thereof: where: R1, R2 and R3 are independently selected from the group consisting of hydrogen, F, Cl, Br, I, —NR5R6, —(C 1 -C 6 )alkyl, —(C 1 -C 6 ) substituted alkyl, —(C 3 -C 9 )cycloalkyl, —(C 3 -C 9 ) substituted cycloalkyl, —O—(C 1 -C 6 )alkyl, —O—(C 1 -C 6 ) substituted alkyl, —O—(C 3 -C 9 )cycloalkyl, and —O—(C 3 -C 9 ) substituted cycloalkyl, aryl, heteroaryl, heterocyclyl; R4 is independently selected from the group consisting of hydrogen, —(C 1 -C 6 )alkyl, —CH 2 R7; R5, R6 are independently selected from the group consisting of hydrogen, and —(C 1 -C 6 )alkyl; R7 is independently selected from the group consisting of —O—P(═O)(OH) 2 , —O—P(═O)(—OH)(—O—(C 1 -C 6 )alkyl), —O—P(═O)(—O—(C 1 -C 6 )alkyl) 2 , —O—P(═O)(—OH) (—O—(CH 2 )-phenyl), —O—P(═O)(—O—(CH 2 )-phenyl) 2 , a carboxylic acid group, an amino carboxylic acid group and a peptide; Q is selected from the group consisting of aryl, heteroaryl, —O-aryl, —S-aryl, —O-heteroaryl, and —S-heteroaryl; X is —(NR8)-; R8 is independently selected from the group consisting of hydrogen, —(C 1 -C 6 )alkyl, —(C 1 -C 6 ) substituted alkyl, —(C 3 -C 9 )cycloalkyl, —(C 3 -C 9 ) substituted cycloalkyl, and —O—(C 1 -C 6 )alkyl, —C(═O)—O—(C 1 -C 6 )alkyl and —C(═O)—O—(C 1 -C 6 ) substituted alkyl; Y is —(CH 2 )—; wherein said aryl, heteroaryl, —O-aryl, —S-aryl, —O-heteroaryl, and —S-heteroaryl groups may be substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, —NR5R6, —(C 1 -C 6 )alkyl, —(C 1 -C 6 ) substituted alkyl, —(C 3 -C 9 )cycloalkyl, —(C 3 -C 9 ) substituted cycloalkyl, —O—(C 1 -C 6 )alkyl, —O—(C 1 -C 6 ) substituted alkyl, —O—(C 3 -C 9 )cycloalkyl, —O—(C 3 -C 9 ) substituted cycloalkyl, -aryl, -aryl-(C 1 -C 6 )alkyl, -aryl-O—(C 1 -C 6 )alkyl, —O-aryl, —O—(C 1 -C 4 )alkyl-aryl, heteroaryl, heterocyclyl, —O—(C 1 -C 4 ) alkyl-heterocycle, and —(S(═O) 2 )—(C 1 -C 6 )alkyl; and m is 1.