Patent ID: 7358253

Claim:
A method for treating acute or chronic rejection of organ or tissue allo- or xenografts or graft versus host disease in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a compound of formula I wherein R a is H; CH 3 ; CH 2 -CH 3 ; or isopropyl, R b is H; halogen; C 1-6 alkoxy; or C 1-6 alkyl, and either I. R is a radical of formula (a) wherein R 1 is piperazin-1-yl optionally substituted by CH 3 in position 3 or 4; or 4,7-diaza-spiro [2.5] oct-7-yl; R 2 is Cl; Br; CF 3 ; or CH 3 ; and R 3 is H; CH 3 ; or CF 3 ; R 2 being other than CH 3 or Cl when R 3 is H, R a is H or CH 3 , R b is H and R 1 is 4-methyl-1-piperazinyl; or II. R is a radical of formula (b) wherein R 4 is piperazin-1-yl substituted in positions 3 and/or 4 by CH 3 ; or 4,7-diaza-spiro [2.5] oct-7-yl; R a being other than H or CH 3 when R 4 is 4-methyl-1-piperazinyl; or II. R is a residue of formula (c) wherein R 14 is 4,7-diaza-spiro [2.5] oct-7-yl; R 15 is halogen; CF 3 ; or CH 3 ; R 15 being other than CH 3 when R 16 is CH 3 , R a is H or CH 3 , and R b is H; and R 16 is H; CH 3 ; CH 2 -CH 3 ; or CF 3 ; R 16 being other than H when R 15 is Cl, R a is H or CH 3 , and R b is H; or IV. R is a radical of formula (d) wherein R 8 is 1-piperazinyl, 3-methyl-piperazin-1-yl or 4-benzyl-piperazin-1-yl; or V. R is a radical of formula (e) wherein R 9 is 4,7-diaza-spiro [2.5] oct-7-yl; or 1-piperazinyl substituted in position 3 by methyl or ethyl and optionally in position 4 by methyl; or a pharmaceutically acceptable salt thereof.