Patent ID: 8377932

Claim:
A 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compound, having a structural formula (XIII), Structural formula XIII: wherein R1-R4 and R12 are selected from H, CN, NO 2 , hydroxyl, amino, a halogen atom, C 1 -C 6 alkoxyl, NR 10 R 11 , OR 13 , C(O)R 14 , O—C(O)R 14 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl and a carboxylic ester; wherein R1-R4 and R12 are not simultaneously H, R 14 is selected from C 1 -C 6 alkyl; wherein OR 13 is selected from hydroxyalkyl or alkoxyalkyl; wherein in NR 10 R 11 , R 10 and R 11 are selected from H, C 1 -C 6 hydroxyalkyl, esterified C 1 -C 6 -hydroxyalkyl, C 1 -C 6 alkoxyalkyl, or structural formula XIV, Structural formula XIV: wherein in structural formula XIV, R5 is selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, and C 2 -C 6 alkenyl; R6-R9 are selected from H, C 1 -C 6 alkoxy, ═O, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 hydroxyalkyl, and C 2 -C 4 alkenyl; X is selected from N and CH; Y is selected from N, O, and C, wherein when Y is O, R5 is absent; and n is 1-6; and pharmaceutically acceptable salts thereof.