Patent ID: 8470818

Claim:
A method for treating a subject suffering from a B-Raf or c-Raf-1 protein kinase mediated disease or condition, said method comprising administering to the subject a compound effective for the treatment of the B-Raf or c-Raf-1 protein kinase mediated disease or condition, said compound having the structure of Formula IIIm: or a pharmaceutically acceptable salt thereof, R 81 is selected from the group consisting of hydrogen; halogen; C 1-6 alkyl optionally substituted with carboxylic acid; C 2-6 alkenyl optionally substituted with carboxylic acid; C 1-6 alkoxy optionally substituted with methoxy or diethylamine; carboxylic acid; carboxylic acid methyl ester; carboxylic acid ethylamide; 4-methyl-piperidin-1-yl; 4-methyl-piperazin-1-yl; morpholin-4-yl; phenyl-amino; phenyl optionally substituted with halogen, —CN, optionally fluoro substituted C 1-6 alkyl, dimethylamine, methoxy, carboxylic acid, carboxylic acid amide, carboxylic acid-dimethyl amide, morpholine-4-carbonyl, morpholine, morpholine-4-methyl, or 2-methoxy-ethoxy; pyridinyl optionally substituted with methoxy, morpholine, or 4-methyl-piperazin-1-yl; 4-methyl-1H-imidazol-2-yl; and N-methyl-pyrazolyl; R 83 is selected from the group consisting of hydrogen, fluoro and chloro; R 112 is selected from the group consisting of C 2-6 alkyl; phenyl optionally substituted with —CN, —NO 2 , acetamide, halogen, optionally fluoro substituted C 1-6 alkyl, optionally fluoro substituted C 1-6 alkoxy, or oxazolyl; 2,3-dihydro-benzo[1,4]dioxin-6-yl; methyl substituted thiazole, methyl substituted imidazole, thiophene optionally substituted with methyl, oxazole, isoxazole, or pyridine; furan substituted with methyl or carboxylic acid methyl ester; benzothiazol-6-yl; benzo[b]thiophen-2-yl; piperidin-1-yl; and dimethylamine wherein said disease or condition is selected from the group consisting of acute myeloid leukemia, melanoma, gliomas, sarcomas, histiocytic lymphoma, neurofibromatosis, myelodysplastic syndrome, tumor angiogenesis, thyroid cancer, liver cancer, colorectal cancer, pancreatic cancer, breast cancer, ovarian cancer, lung cancer, polycystic kidney disease and cardio-faciocutaneous syndrome.