Patent ID: 7524845

Claim:
A compound having a formula selected from the group consisting of: or a pharmaceutically acceptable salt, hydrate or N-oxide thereof, wherein the subscript m is an integer of from 0 to 2; each R 1 is independently selected from the group consisting of —CO 2 H and C 1-4 alkyl, optionally substituted with —OH, —OR m , —S(O) 2 R m , —CO 2 H or —CO 2 R m wherein R m is an unsubstituted C 1-6 alkyl; R 2a , R 2c and R 2d are each independently selected from the group consisting of hydrogen, halogen, cyano, oxazolyl, —NO 2, —CO 2 R c , —CONR c R d , —C(O)R c , —S(O) 2 R e , —R e , —C(NOR c )R d , —OR c , —SR c , —NR d C(O)R c , —X 2 OR c , —O—X 2 OR c , —X 2 NR c R d , —NR c S(O) 2 R e , —OC(O)R c , and —NR c R d ; wherein within each of R 2a , R 2c and R 2d , X 2 is C 1-4 alkylene and each R c and R d is independently selected from hydrogen, C 1-8 alkyl, C 1-8 haloalkyl, and C 3-6 cycloalkyl and each R e is independently selected from the group consisting of C 1-8 alkyl, C 1-8 haloalkyl, and C 3-6 cycloalkyl; each of ring vertices a, b, c and d in formulae Ia and Ib is independently selected from N and CH, and one of said ring vertices is N; and R 3a is selected from the group consisting of hydrogen, halogen, —NR f R g , —R h , —S(O) 2 R h , and —Y, wherein Y is selected from the group consisting of homopiperidinyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, piperidinyl, azetidinyl, pyranyl, tetrahydrofuranyl, piperazinyl, phenyl, thienyl, furanyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, triazolyl, tetrazolyl and oxadiazolyl, optionally substituted with from one to three substitutents selected from the group consisting of halogen, —OR f , —NR f R g , —R h ,—CN, —NO 2, —CO 2 R f , —CONR f R g , and —C(O)R f , wherein each R f and R g is independently selected from hydrogen, C 1-8 alkyl, C 1-8 haloalkyl, and C 3-6 cycloalkyl, and each R h is independently selected from the group consisting of C 1-8 alkyl, C 1-8 haloalkyl, and C 3-6 cycloalkyl.