Patent ID: 7750004

Claim:
A compound having formula (I), or a therapeutically acceptable salt thereof, wherein A 1 is A 2 ; A 2 is C 1 -C 5 -alkyl, C 2 -C 5 -alkenyl or C 2 -C 5 -alkynyl, each of which is substituted with R 1 ; R 1 is R 2 or R 3 ; R 2 is phenyl which is unfused or fused with benzene, heteroarene or cycloalkane; R 3 is heteroaryl which is unfused or fused with benzene; B 1 is phenyl substituted with one F; and C 1 is C(O)OH; wherein R 2 and R 3 are independently unsubstituted or substituted with one or two or three or four or five of independently selected R 17 , OR 17 , SR 17 , S(O)R 17 , SO 2 R 17 , C(O)R 17 , CO(O)R 17 , OC(O)R 17 , OC(O)OR 17 , NH 2 , NHR 17 , N(R 17 ) 2 , NHC(O)R 17 , C(O)NH 2 , C(O)NHR 17 , C(O)N(R 17 ) 2 , C(O)NHOH, C(O)NHOR 17 , C(O)NHSO 2 R 17 , C(O)NR 17 , NHSO 2 R 17 , N(SO 2 R 17 ) 2 , SO 2 NH 2 , SO 2 NHR 17 , SO 2 N(R 17 ) 2 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 17 , C(N)N(R 17 ) 2 , N═NR 17 , CNOH, CNOCH 3 , OH, (O), N 3 , NO 2 , CF 3 , CF 2 CF 3 , CF 2 Cl, SO 2 CF 3 , SO 2 CF 2 CF 3 , SO 2 CF 2 Cl, NHSO 2 CF 3 , NHSO 2 CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I, wherein R 17 is R 18 , R 20 , R 20 or R 21 ; R 18 is phenyl which is unfused or fused with benzene, heteroarene or R l8A , wherein R 18A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 19 is heteroaryl which is unfused or fused with benzene, heteroarene or R l9A , wherein R 19A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 20 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R 20A wherein R 20A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; R 21 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with one or two of independently selected alkyl, alkenyl, alkynyl, R 22 , OR 22 , NHR 22 , SR 22 , S(O)R 22 or SO 2 R 22 ; and R 22 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with, benzene, heteroarene or R 22A , wherein R 22A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; wherein the cyclic moieties represented by R 18 , R 18A , R 19 , R 19A , R 20 , R 20A , R 22 and R 22A are independently unsubstituted or substituted with one or two or three or four or five of independently selected R 23 , OR 23 , NHR 23 , N(R 23 ) 2 , SR 23 , S(O)R 23 or SO 2 R 23 , CF 3 , CF 2 CF 3 , OH, NH 2 , NHCH 3 , N(CH 3 ) 2 , N 3 , NO 2 , CF 3 , CF 2 CF 3 , NHSO 2 CF 3 , NHSO 2 CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I; wherein R 23 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl or R 24 ; and R 24 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl.