Patent ID: 7267829

Claim:
A liquid transdermal delivery system (TDS) for treatment of a living body by rapidly delivering an effective dose of at least 0.25 mg/cm2/day of at least one active agent across the skin by application of said TDS to an area of the skin, said TDS comprising, in combination, said at least one active agent and a solvent system in which the active agent is at least substantially soluble, said solvent system including at least one solvent modifying compound to facilitate transdermal delivery of the active agent and to increase solubility of said active agent in said solvent system; and at least one active agent modifying compound forming a non-covalently bonded complex with the active agent, said at least one active agent having a molecular weight in excess of 300 Daltons, wherein said solvent system is selected so as to exhibit van der Waals forces subsequent to inclusion of said active agent which closely approximate those exhibited by said solvent system alone; said act of solvent system selection including determining the van der Waals forces of the active agent, selecting a solvent system such that the weighted average of van der Waals forces of components of said solvent system closely approximate the van der Waals forces of said active agent, and such that upon combination of said solvent system and said active agent to form said TDS, the van der Waals forces of said TDS closely approximate the van der Waals forces of said active agent and said solvent system prior to formation of said TDS; wherein said transdermal delivery system includes (a) a medically effective active ingredient, and (b) a carrier composition comprising: (i) at least one non-agueous non-toxic solvent selected from the group consisting of lower aliphatic mono-hydroxy and poly-hydroxy compounds; (ii) limonene, lemon oil or mixture of limonene and lemon oil; (iii) methylsulfonylmethane; (iv) a skin stabilizer which comprises at least one compound selected from the group consisting of an aliphatic carboxylic acid having from 8 to 32 carbon atoms, an ester of said aliphatic carboxylic acid with an aliphatic alcohol having from 1 to 20 carbon atoms, wherein said ester has a total of from 9 to 36 carbon atoms; and Vitamin D3; and (v) a solute modifier which comprises a compound selected from the group consisting of 3,3′-thiodipropionic acid, Uncaris Tormentosa, an oxindole alkaloid, a polyphenolic flavonoid, a sugar adduct of a gluconuide, isoflavones, phosphatidyl serine, phosphatidyl choline, Vitamin D3 and Vitamin K1.