Patent ID: 6878720

Claim:
A method of treating a warm-blooded animal with a neoplastic disease that responds to an inhibitor of VEGF receptor tyrosine kinase, which comprises administering to the warm-blooded animal an effective amount of a compound of formula I, wherein W is O or S; X is NR 8 ; Y is CR 9 R 10 —(CH 2 ) n wherein R 9 and R 10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO 2 ; R 1 is aryl; R 2 is a bicyclic heteroaryl group comprising one ring heteroatom wherein the heteroatom is nitrogen with the exception that R 2 cannot represent 2-phthalimidyl; any of R 3 , R 4 , R 5 and R 6 , independently of the other, is H, halogen, or lower alkyl; and R 7 and R 8 , independently of each other, are H or lower alkyl; or an N-oxide or a pharmaceutically acceptable salt thereof; wherein the neoplastic disease is selected from solid tumors, leukemias, liquid tumors expressing c-kit, KDR or fit-1; breast cancer; cancer of the colon; lung cancer; small-cell lung cancer; cancer of the prostate; and Kaposi's sarcoma.