Patent ID: 8921346

Claim:
A preparation method of drospirenone, comprising the following steps: providing 3β,5-dyhydroxy-6β,7β,15β,16β-dimethylene-5β-androstane-17,20-epoxy of Formula I as raw material; oxidizing a hydroxyl at the 3 rd position to obtain an oxide of Formula II, and then protecting the 3-ketone group by ketalization to obtain the ketal product of Formula III; the obtained ketal product being made into the compound of Formula, IV after condensation reaction, and then obtaining the lactone compound of Formula V after deesterification; the hydroxyl at the 5 th position being subject to sulfonation and esterification to obtain the sulfonyl compound of Formula VI; and the deketalization and desulphonation being performed in the reaction system of the glacial acetic acid and sodium acetate to produce a 3-keto-4-alkenyl compound, thus obtaining drospirenone of Formula VII in formula VI, R being C 1 -C 10 alkyl, phenyl, or tolyl.