Patent ID: 8721711

Claim:
A device for the local delivery of a drug-containing solution into a natural tissue conduit in a mammalian body, comprising: a prosthetic graft configured to be affixed to the natural tissue conduit to provide a lumen connecting at least two segments of the natural tissue conduit, the prosthetic graft comprising a reservoir comprising a microporous membrane, the microporous membrane being microporous relative to a drug-containing solution; and a pump provided to introduce the drug-containing solution to the reservoir at an infusion rate no greater than 1.0 ml/day and produce a threshold pressure within the reservoir, wherein the microporous membrane has a porosity to restrain the drug-containing solution within the reservoir and release the drug-containing solution from the reservoir to bloodstream in the lumen of the prosthetic graft upon application of the threshold pressure, wherein the microporous membrane releases the drug-containing solution locally and substantially uniformly around an internal circumference of the prosthetic graft lumen and thereby to at least one of the at least two segments of the natural tissue conduit.