Patent ID: 8883159

Claim:
An isolated antibody that specifically binds to human CDCP1, characterized in that (a) the heavy chain variable domain comprises a CDRH1 region of SEQ ID NO:9, a CDRH2 region of SEQ ID NO:10, and a CDRH3 region of SEQ ID NO:11, and the light chain variable domain comprises a CDRL1 region of SEQ ID NO:12, a CDRL2 region of SEQ ID NO:13, and a CDRL3 region of SEQ ID NO:14, or (b) the heavy chain variable domain comprises a CDRH1 region of SEQ ID NO:17, a CDRH2 region of SEQ ID NO:18, and a CDRH3 region of SEQ ID NO:19, and the light chain variable domain comprises a CDRL1 region of SEQ ID NO:20, a CDRL2 region of SEQ ID NO:21, and a CDRL3 region of SEQ ID NO:22, or (c) the heavy chain variable domain comprises a CDRH1 region of SEQ ID NO:25, a CDRH2 region of SEQ ID NO:26, and a CDRH3 region of SEQ ID NO:27, and the light chain variable domain comprises a CDRL1 region of SEQ ID NO:28, a CDRL2 region of SEQ ID NO:29, and a CDRL3 region of SEQ ID NO:30, or (d) a humanized version of (a), (b) or (c), wherein the isolated antibody shows more than 50% internalization after 5 hours in MDAMB-231 cells as compared to an untreated control.