Patent ID: 7956185

Claim:
A compound having formula (I) or a therapeutically acceptable salt thereof, wherein X 1 is N(A 1 )(B 1 ); A 1 is R 1 ; B 1 is H; R 1 is R 2 , R 4 or R 5 ; R 2 is phenyl; R 4 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; R 5 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with one, two or three of independently selected R 6 , OR 6 , C(O)OR 6 , C(O)NH 2 , C(O)NHR 6 , C(O)N(R 6 ) 2 , NHC(O)R 6 , NR 6 C(O)R 6 , OH, (O), CN, NH 2 , NHR 6 , N(R 6 ) 2 , F, Cl, Br or I; R 6 is R 7 or R 9 ; R 7 is phenyl; R 9 cycloalkyl or heterocycloalkyl; C 1 is H; D 1 is R 18 or R 20 ; R 18 is pyrimidinyl which is substituted with NHR 21 or N(CH 3 )R 21 ; and optionally substituted with one or two of CN, NO 2 , F, Cl, Br, or I; R 20 is furanyl, imidazolyl, isothiazolyl, isoxazolyl, 1,2,3-oxadiazoyl, 1,2,5-oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyrrolyl, 1,2,4-thiadiazolyl, thiazolyl, thiophenyl, triazinyl or 1,2,3-triazolyl, each of which is substituted with NHR 21 or N(CH 3 )R 21 ; R 21 is R 22 or R 23 ; R 22 is phenyl which is unfused or fused with benzene or R 22A ; R 22A is cycloalkyl or heterocycloalkyl; R 23 is heteroaryl; wherein R 22 and R 23 are independently unsubstituted or substituted with one, two, three, four or five of independently selected R 30 , OR 30 , SR 30 , S(O)R 30 , SO 2 R 30 , C(O)R 30 , CO(O)R 30 , OC(O)R 30 , OC(O)OR 30 , NH 2 , NHR 30 , N(R 30 ) 2 , C(O)NH 2 , C(O)NHR 30 , C(O)N(R 30 ) 2 , SO 2 NH 2 , SO 2 NHR 30 , NHSO 2 R 30 , N(R 30 )SO 2 R 30 , SO 2 N(R 30 ) 2 , CF 3 , CF 2 CF 3 , C(O)H, CN, C(O)OH, (O), OH, NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I; R 31 is R 31 , R 32 , R 33 or R 34 ; R 31 is phenyl; R 32 is heteroaryl; R 33 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocloalkenyl; R 34 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with one, two or three of independently selected R 35 , OR 35 , SR 35 , C(O)OR 35 , NH 2 , NHR 35 , OH, N(R 35 ) 2 , C(O)NH 2 , C(O)NHR 35 , C(O)N(R 35 ) 2 , NHC(O)R 35 , N(R 35 )C(O)R 35 , F, Cl, Br or I; R 35 is R 36 , R 37 , R 38 or R 39 ; R 36 is phenyl; R 37 is heteroaryl; R 38 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocloalkenyl; the moieties represented by R 31 , R 32 , R 33 , R 36 , R 37 , and R 38 are independently unsubstituted or substituted with one, two, three, four or five of independently substituted R 39 , OR 39 , C(O)OR 39 , NH 2 , NHR 39 , N(R 39 ) 2 , C(O)NH 2 , C(O)NHR 39 , C(O)N(R 39 ) 2 , NHC(O)R 39 , N(R 39 )C(O)R 39 , SO 2 NH 2 , SO 2 NHR 39 , SO 2 N(R 39 ) 2 , (O), CN, F, Cl, Br or I; and R 39 is alkyl.