Patent ID: 8569332

Claim:
A method of inhibiting metastasis of a lymphatic tumor in a human patient afflicted with a lymphatic cancer, the method comprising administering to the patient, in an amount sufficient to inhibit lymphocyte proliferation, a rapamycin derivative having the chemical structure wherein X is (H, H) or O; Y is (H, OH) or O; each of R 1 and R 2 independently ndependently selected from the group consisting of —H, alkyl, thioalkyl, arylalkyl, hydroxyalkyl, dihydroxyalkyl, hydroxyalkylarylalkyl, dihydroxyalkylarylalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, arylsulfonamidoalkyl, allyl, dihydroxyalkylallyl, dioxolanylallyl, carbalkoxyalkyl, and (R 3 ) 3 Si; each R 3 is independently selected from the group consisting of —H, methyl, ethyl, isopropyl, tert-butyl, and phenyl; and either R 4 is methyl or R 4 and R 1 together form a C 2-5 alkylene moiety.