Patent ID: 7858090

Claim:
A composition comprising a protein having a fibronectin type III domain that binds to a specific binding partner (SBP), wherein the fibronectin type III domain comprises at least two fibronectin type III β-strand domains from the 10th type III domain of human fibronectin with a loop region linked between each β-strand domain, wherein the integrin-binding domain has been removed from the FG loop of the fibronectin type III domain, wherein at least one loop region comprises an AB, BC, CD, DE, or the FG loop region sequence that is randomized or varies as compared to the wild-type fibronectin type III loop region (SEQ ID NO: 110; FIG. 2 ) by deletion of two to twelve amino acids in the loop region, insertion of at least two to 25 amino acids in the loop region, or replacement of at least two amino acids in the loop region.