Patent ID: 7994175

Claim:
A method for providing a benefit to human skin comprising topically applying to the skin of an individual in need thereof an effective amount of 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamide or cosmetically acceptable salt thereof in a cosmetically acceptable vehicle comprising a water-in-oil or oil-in-water emulsion, wherein said 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamide has the structure of formula I: where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are independently hydrogen or a group —R 9 -R 10 ; R 9 represents, independently at each occurrence, a bond; an aliphatic C 1 -C 20 hydrocarbon radical; a C 1 -C 20 aromatic hydrocarbon radical; or a C 1 -C 20 heteroaryl radical; R 10 is selected independently at each occurrence from hydrogen; —F; —Cl; —Br; —I; —OH; —OR; —NH 2 ; —NHR; —N(R) 2 ; —N(R) 3 + ; —N(R)—OH; —N(→O)(R) 2 ; —O—N(R) 2 ; —N(R)—O—R; —N(R)—N(R) 2 ; —C═N—R; —N═C(R) 2 ; —C═N—N(R) 2 ; —C(═NR)—N(R) 2 ; —SH; —SR; —CN; —NC; —CHO; —CO 2 H; —CO 2 − ; —CO 2 R; —(C═O)—S—R; —O—(C═O)—H; —O—(C═O)—R; —S—(C═O)—R; —(C═O)—NH 2 ; —(C═O)—N(R) 2 ; —(C═O)—NHNH 2 ; —O—(C═O)—NHNH 2 ; —(C═S)—NH 2 ; —(C═S)—N(R) 2 ; —N(R)—CHO; —N(R)—(C═O)—R; —(C═NR)—O—R; —O—(C═NR)—R; —SCN; —NCS; —NSO; —SSR; —N(R)—C(═O)—N(R) 2 ; —N(R)—C(═S)—N(R) 2 ; —SO 2 —R; —O—S(═O) 2 —R; —S(═O) 2 —OR; —N(R)—SO 2 —R; —SO 2 —N(R) 2 ; —O—SO 3 − ; —O—S(═O) 2 —OR; —O—S(═O)—OR; —O—S(═O)—R; —S(═O)—OR; —S(═O)—R; —NO; —NO 2 ; —NO 3 ; —O—NO; —O—NO 2 ; —N 3 ; —N 2 —R; —N(C 2 H 4 ); —Si(—R) 3 ; —CF 3 ; —O—CF 3 ; —(C═O)—R; —PR 2 ; —O—P(═O)(OR) 2 ; —P(═O)(OR) 2 ; ═O; ═S; ═NR; an aliphatic C 1 -C 20 hydrocarbon radical; a C 1 -C 20 aromatic hydrocarbon radical; or a C 1 -C 20 heteroaryl radical; where R is independently at each occurrence hydrogen or a saturated, partially saturated, or aromatic C 1 -C 20 hydrocarbon radical or halogenated derivative thereof; and where any two adjacent groups R 1 , R 2 , R 3 , R 4 , and R 5 may, together with the phenyl ring to which they are attached, form a five-membered or six-membered aliphatic or aromatic ring, optionally substituted with one or more groups R 10 and optionally including one or more heteroatoms selected from O, N, or S in the ring.