Patent ID: 8764968

Claim:
A method for controlling a molecule in a nanodevice, comprising: filling a reservoir with ionic fluid; configuring a membrane to separate the reservoir, the membrane comprises electrode layers separated by insulating layers in which the electrode layers have an organic coating; forming a nanopore through the membrane, the organic coating on the electrode layers forms transient bonds to a base of the molecule in the nanopore; wherein, when a first voltage is applied to the electrode layers, a tunneling current is generated by the base in the nanopore, such that the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base; and breaking the transient bonds of the organic coating by applying an electric field above a threshold for breaking the transient bonds; wherein to attach to the electrode layers, the organic coating includes a selection from thiols, isocyanides, diazonium salts, phosphonic acid, hydroxamic acid, and resorcinol based on a type of material of the electrode layers; and wherein to form the transient bonds with the base, the organic coating includes a selection from alcohols, carboxylic acids, carboxamides, sulfonamides, and sulfonic acids.