Patent ID: 7932406

Claim:
A method for synthesising a halogenohydrate of 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of formula 1 in which X represents a halogen atom selected from the group consisting of chlorine, bromine and iodine; comprising the following stages: reaction, in a pure weak acid, without another solvent, at a temperature greater than ambient temperature of thiourea with 4β-halogenoacetamino-4′-demethyl-4-desoxypodophyllotoxin of formula 3 in which X represents a halogen atom selected from the group composed of chlorine, bromine and iodine, advantageously chlorine; and recovery of the halogenohydrate of 4β-amino-4′-demethyl-4-desoxypodophyllotoxin.