Patent ID: 7671057

Claim:
A method for treatment for type II diabetes comprising administering an effective dose of a compound represented by the general formula (I): wherein R 1 and R 2 each independently are a hydrogen atom, a C1-4 alkyl, C1-4 alkoxy or C2-5 acyl group, a halogen atom, a nitro or benzoyl group, or COOR 4 (where R 4 is a C1-3 alkyl group); A is a single bond, a C1-4 alkylene group, or a group represented by the formula: where R 5 and R 6 each independently are a hydrogen atom or a C1-4 alkyl group; R 3 is a group represented by the general formula: where R 7 and R 8 each independently are (1) a hydrogen atom, (2) a phenyl group, (3) a C7-10 phenylalkyl group, (4) a phenyl group substituted by one or more substituents selected from a C1-4 alkyl group, a halogen atom and —R 11 —COOR 12 (where R 11 is a single bond, a C1-8 alkylene, C2-8 alkenylene or C2-8 alkynylene group; R 12 is a hydrogen atom, a C1-4 alkyl, C7-10 phenylalkyl, phenyl, aryl or propargyl group) or a C7-10 phenylalkyl group, (5) a C1-10 alkyl group, (6) a C2-10 alkenyl group having 1 to 3 double bonds, (7) a C2-10 alkynyl group having 1 to 2 triple bonds, (8) —R 11a —COXR 12 (where R 11a is a single bond, a C1-8 alkylene group, a C2-8 alkylene group having one or two carbon atoms in the principal chain being substituted by a sulfur atom or a sulfur atom and a phenylene group, a C2-8 alkenylene group, a C4-8 alkenylene group having one or two carbon atoms in the principal chain being substituted by a sulfur atom, or a sulfur atom and a phenylene group, a C2-8 alkynylene group, or a C4-8 alkynylene group having one or two carbon atoms in the principal chain substituted by a sulfur atom or a sulfur atom and a phenylene group; X is an oxygen atom or NH; R 12 has the same meaning as described above), (9) a C1-4 alkyl group substituted by a 7-14 membered, bi- or tri-cyclic hetero ring containing one nitrogen atom, (10) a C3-7 cycloalkyl group or (11) a C1-6 alkyl group substituted by a C1-4 alkoxy group; R 9 is (1) a hydrogen atom, (2) a C1-8 alkyl group, (3) a C7-10 phenylalkyl group, (4) a C2-10 alkenyl group having 1 to 3 double bonds, (5) a C2-10 alkynyl group having 1 to 2 triple bonds, (6) —R 11 —COOR 12 (where R 11 and R 12 have the same meaning as described above), (7) a C3-7 cycloalkyl group, or (8) a C1-6 alkyl group substituted by a C1-4 alkoxy group; the symbol: is a 4-7 membered, mono-cyclic hetero ring containing one or two nitrogen atoms; R 10 is (1) a hydrogen atom, (2) a C7-10 phenylalkyl group, or (3) COOR 13 (wherein, R 13 is a hydrogen atom, a C1-4 alkyl or C7-10 phenylalkyl group), with the proviso that R 7 and R 8 shall not represent a hydrogen atom at the same time and, when at least one group of R 7 , R 8 and R 9 represents a group containing t-butyl ester, the other groups shall not represent a group containing carboxyl, or a salt thereof.