Patent ID: 8211904

Claim:
A compound of formula (I): or its tautomer (I′) wherein X is N; X′ is NH; Y is selected from the group consisting of (1) O, and (2) S; R 1 is selected from the group consisting of (1) —C 1-10 alkyl, and (2) —C 3-12 cycloalkyl, wherein one or two of the ring carbon atoms is optionally replaced by a —Si(C 1-6 alkyl) 2 — group, wherein said alkyl and said cycloalkyl R 1 moiety is optionally substituted with one or more (a) halo, and (b) —C 1-10 alkyl; R 2 is selected from the group consisting of phenyl or thienyl, wherein said phenyl or thienyl R 2 moiety is optionally substituted with one or more (a) halo, and (b) —C 0-6 alkyl-aryl, wherein said aryl is optionally substituted with one or more —SO 2 Cl 1-3 alkyl; Q is —C 1-6 alkylene, wherein said alkylene is optionally substituted with one or more (a) halo, (b) —OH, (c) —CN, (d) —C 1-10 alkyl (e) —C 3-12 cycloalkyl, (f) —O—C 1-10 alkyl, (g) aryl, and (h) heteroaryl; R 3 is selected from the group consisting of phenyl or —C 3-12 cycloalkyl, wherein said phenyl or cycloalkyl, R 3 moiety is optionally substituted with one or more (a) halo, (b) —C 2-10 alkenyl, (c) —C 3-12 cycloalkyl, (d) —O—C — 12 cycloalkyl, (e) —O—C 1-10 alkyl, (f) —O—C 3-12 heterocyclic, wherein said heterocyclic group has from 4 to 8 ring atoms, wherein one ring atom is a heteroatom selected from the group consisting of nitrogen, sulfur and oxygen, and (g) heteroaryl; R 4 is —C 2-4 alkenyl; and pharmaceutically acceptable salts thereof, and individual enantiomers and diastereomers thereof.