Patent ID: RE39113

Claim:
A method of treating acute pain, neuropathic pain or nociceptive pain in a mammal which comprises administering to a patient in need thereof an effective amount of a derivative of tetrahydropyridines of formula (II) wherein R 1 , R 2 and R 3 are identical or different and are selected from hydrogen, halogen, C 1 -C 4 alkyl group, trifluoroethyl radical, hydroxyl or alkoxyl radical; and two adjacent radicals can form part of a six-member aromatic ring; A is selected from a carbon atom or a carbon atom bound to a hydroxyl group (C—OH); wherein when A is a carbon atom the dotted line (- - -) represents a bond, and when A is a carbon atom bound to a hydroxyl group (C—OH) the dotted line (- - -) represents no bond; Z 1 , is a nitrogen atom or a substituted carbon atom represented by the formula C—R 4 ; Z 2 is a nitrogen atom or a substituted carbon atom represented by the formula C—R 5 ; Z 4 is a nitrogen atom or a substituted carbon atom represented by the formula C—R 7 ; with the condition that Z 1 ; Z 2 and Z 4 taken together can represent, at most, two nitrogen atoms; and R 4 , R 5 , R 6 and R 7 , are identical or different and are selected from hydrogen, halogen, C 1 -C 4 alkyl group, aryl or substituted aryl group, and two adjacent radicals can form part of a six-member aromatic ring; or physiologically acceptable salts thereof.