Patent ID: 8552043

Claim:
A method of inhibiting HIV reverse transcriptase, the method comprising contacting HIV reverse transcriptase with a compound of formula 1: wherein: R 1 is Cl, Br, I, CH 3 , CF 3 , CHF 2 or CH 2 F; R 3 is H or CH 3 ; R o is Cl, Br, CF 3 or methyl; X is O or NH; R 2 is H, a pharmaceutically acceptable cation or C 1-3 alkyl, when X is O; or XR 2 is NHCH 2 CH 2 COOR 13 or NHCH(R 12 )COOR 13 ; where R 12 is C 1-4 alkyl or aryl-C 1-4 alkyl; and R 13 is a pharmaceutically acceptable cation or C 1-3 alkyl; Ar is selected from the group consisting of (a), (b), (c) and (d): wherein R P is selected from the group consisting of methyl, ethyl, propyl, isopropyl, cyclopropylmethyl, and C 3-6 cycloalkyl; R 4 , R 5 and R 6 are independently selected from the group consisting of H, F, Cl, Br, CF 3 , CFH 2 , CF 2 H, ethyl, isopropyl, cyclopropyl, OCH 3 , OH, OCF 3 , NH 2 and NHCH 3 ; R 7 is selected from the group consisting of Cl, Br, I, CF 3 , OCH 3 , isopropyl, cyclopropyl, tent-butyl, and cyclobutyl; and R 8 , R 9 , R 10 and R 11 are independently H or CH 3 .