Patent ID: 8338596

Claim:
A process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]-pyrimidin-2-amines of the formula (I), in which X represents halogen or OR; and R represents C 1 -C 4 alkyl; which comprises: i) contacting a 2-substituted-4-amino-5-alkoxypyrimidine of the formula in which X and R are as previously defined with an isothiocyanatidocarbonate of the formula in which R is as previously defined, in a polar aprotic solvent to provide a (pyrimidinylamino)carbonothioylcarbamate of the formula in which X and R are as previously defined; ii) contacting the (pyrimidinylamino)carbonothioylcarbamate with hydroxylamine in the presence of a base to provide a (pyrimidinylamino)hydroxyimino)methylcarbamate of the formula in which X and R are as previously defined; and iii) cyclizing the (pyrimidinylamino)hydroxyimino)methylcarbamate by heating in an inert solvent to provide the 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amine.