Patent ID: 7291643

Claim:
A compound having the structure of formula I, or a pharmaceutically acceptable salt thereof: wherein: R 1 is selected from the group consisting of: H, CN, SO 2 —C 1 -C 6 alkyl, SO 2 —C 3 -C 8 cycloalkyl, SO 2 -substituted C 1 -C 6 alkyl, SO 2 -aryl, SO 2 -substituted aryl, SO 2 -heteroaryl, SO 2 -heterocycle, SO 2 —C 3 -C 6 alkenyl, SO 2 —C 3 -C 6 alkynyl, SO 2 —C 3 -C 6 substituted alkenyl, SO 2 —C 3 -C 6 substituted alkynyl, C(O)—C 1 -C 6 alkyl, C(O)—C 3 -C 8 cycloalkyl, C(O)-substituted C 1 -C 6 alkyl, C(O)-aryl, C(O)-substituted aryl, C(O)-heteroaryl, C(O)-heterocycle, C(O)—C 3 -C 6 alkenyl, C(O)—C 3 -C 6 alkynyl, C(O)-substituted C 3 -C 6 alkenyl, C(O)-substituted C 3 -C 6 alkynyl, C(O)O—C 1 -C 6 alkyl, C(O)O—C 3 -C 8 cycloalkyl, C(O)O-substituted C 1 -C 6 alkyl, C(O)O-aryl, C(O)O-substituted aryl, C(O)O-heteroaryl, C(O)O-heterocycle, C(O)O—C 3 -C 6 alkenyl, C(O)O—C 3 -C 6 alkynyl, C(O)O—C 3 -C 6 substituted alkenyl, C(O)O—C 3 -C 6 substituted alkynyl, C(O)NH—C 1 -C 6 alkyl, C(O)NH—C 3 -C 8 cycloalkyl, C(O)N-di-C 3 -C 8 cycloalkyl, C(O)N-di-C 1 -C 6 alkyl, C(O)N-di-substituted C 1 -C 6 alkyl, C(O)NH-substituted C 1 -C 6 alkyl, C(O)NH-aryl, C(O)N-di-aryl, C(O)NH-substituted aryl, C(O)N-diaryl, C(O)NH-heteroaryl, C(O)NH-heterocycle, C(O)N-diheteroaryl, C(O)N-diheterocycle, C(O)NH—C 3 -C 6 alkenyl, C(O)NH—C 3 -C 6 alkynyl, C(O)NH-substituted C 3 -C 6 alkenyl, and C(O)NH-substituted C 3 -C 6 alkynyl; or R 1 is a linking group to a second structure of formula I to form a dimer of formula I, said linking group selected from the group consisting of C(O)— and S(O) 2 —; R 2 is selected from the group consisting of H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, SO 2 -alkyl, and SO 2 -substituted alkyl; provided that at least one of R 1 or R 2 contain a group having an SO 2 — bound to the N or R 1 is a S(O) 2 — linking group; or R 1 and R 2 are joined to form —(C(R 8 ) a (R 9 ) b ) c —SO 2 —(C(R 5 ) d (R 9 ) e ) f —; R 8 and R 9 are, independently, H, halogen, or C 1 to C 6 alkyl; a and b are, independently, 0 to 2, provided that a+b=2; d and e are, independently, 0 to 2, provided that a+b=2; c and f are, independently, 0 to 5, provided that one of c or f is greater than 0; R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of H, halogen, CN, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, —(CH m X n ) z CH p X q , C 3 -C 6 cycloalkyl, O—C 1 -C 6 alkyl, O—C 1 -C 6 substituted alkyl, O—(CH m X n ) z CH p X q , aryl, heteroaryl, heterocycle, substituted aryl, substituted heteroaryl, substituted heterocycle; X is halogen; m and n are, independently, 0 to 2, provided that m+n=2; p and q are, independently, 0 to 3, provided that p+q=3; and z is 0 to 10; R 7 is selected from the group consisting of H, C 1 -C 6 alkyl, C(O)O—C 1 -C 6 alkyl, C 2 to C 6 alkenyl, C 2 to C 6 alkynyl, substituted C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, and substituted C 3 -C 6 cycloalkyl.