Patent ID: 8383796

Claim:
An isolated nucleic acid encoding a heavy chain variable region of an anti-PD-L1 monoclonal antibody, or antigen-binding portion thereof, comprising CDR1, CDR2, and CDR3 domains, wherein the CDR3 domain comprises (a) amino acids having the sequence set forth in SEQ ID NO:41 and conservative modifications thereof; (b) amino acids having the sequence set forth in SEQ ID NO:42 and conservative modifications thereof; (c) amino acids having the sequence set forth in SEQ ID NO:43 and conservative modifications thereof; (d) amino acids having the sequence set forth in SEQ ID NO:44 and conservative modifications thereof; (e) amino acids having the sequence set forth in SEQ ID NO:45 and conservative modifications thereof; (f) amino acids having the sequence set forth in SEQ ID NO:46 and conservative modifications thereof, (g) amino acids having the sequence set forth in SEQ ID NO:47 and conservative modifications thereof; (h) amino acids having the sequence set forth in SEQ ID NO:48 and conservative modifications thereof; (i) amino acids having the sequence set forth in SEQ ID NO:49 and conservative modifications thereof; or (j) amino acids having the sequence set forth in SEQ ID NO:50 and conservative modifications thereof.