Patent ID: 7642229

Claim:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and, as active ingredient, an acryloyl distamycin derivative of formula (I): wherein: R 1 is a bromine or chlorine atom; R 2 is a group of formula (II) wherein m is an integer from 0 to 2; n is an integer from 2 to 5; r is 0 or 1; X and Y are the same or different and are independently, for each heterocyclic ring, a nitrogen atom or a CH group; G is phenylene, a 5 or 6 membered saturated or unsaturated heterocyclic ring with from 1 to 3 heteroatoms selected from the group consisting of N, O and S, or a group of formula III whererin Q is a nitrogen atom or a CH group; and W is an oxygen or sulfur atom or an NR 3 group, wherein R 3 is a hydrogen or C 1 -C 4 alkyl; B is selected from the group consisting of —CN; —NR 5 R 6 ; —CONR 5 R 6 ; —NHCONR 5 R 6 wherein R 4 is cyano, amino, hydroxyl or C 1 -C 4 alkoxy; R 5 , R 6 and R 7 are the same or different and are hydrogen or C 1 -C 4 alkyl; or a pharmaceutically acceptable salt thereof and an antimicrotubule agent, wherein the antimicrotubule agent is docetaxel.