Patent ID: 8158625

Claim:
A compound having the structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein R 1 is selected from the structures: where the wavy line indicates the site of attachment; R 2 is C 1 -C 12 alkyl optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CH 3 , —CH 2 OH, —CN, —CF 3 , —CO 2 H, —COCH 3 , —CO 2 CH 3 , —CONH 2 , —CONHCH 3 , —CON(CH 3 ) 2 , —NO 2 , —NH 2 , —NHCH 3 , —NHCOCH 3 , —NHS(O) 2 CH 3 , —OH, —OCH 3 , —S(O) 2 N(CH 3 ) 2 , —SCH 3 , —CH 2 OCH 3 , and —S(O) 2 CH 3 ; and R 3 is selected from: wherein the IC50 binding activity to p110 delta is ten or more times lower than the binding activity to p110 alpha.