Patent ID: 7687526

Claim:
A compound having the formula I: or a pharmaceutically acceptable salt, stereoisomer, or C 1 -C 6 alkyl ester thereof; or a tautomer or a pharmaceutically acceptable salt, stereoisomer, or C 1 -C 6 alkyl ester thereof; or a mixture thereof, wherein Q is hydrogen; L 1 is a bond; represents an optionally substituted benzo-fused (C 5 -C 8 )cycloalkane ring comprising a benzene ring fused to a (C 5 -C 8 )cycloalkane ring, wherein the benzene ring of the benzo-fused (C 5 -C 8 )cycloalkane ring is bonded to L 2 ; L 2 is oxymethylene; M is an optional substituted benzene ring; X is CR 1 R 1′ ; L 3 is a (C 1 -C 5 )alkylene; A is —CO 2 H; R 1 is cyano, aryl, heteroaryl, heterocycloalkyl, (C 2 -C 8 )alkenyl, (C 3 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 8 )alkynyl, or —C(O)NR 2 R 3 ; R 1′ is hydrogen; and R 2 and R 3 are independently selected from hydrogen, aryl, heteroaryl, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 3 -C 8 )cycloalkyl, or (C 3 -C 8 )heterocycloalkyl; or optionally, R 2 and R 3 are combined to form a 4-, 5-, 6- or 7-membered ring containing the nitrogen atom to which they are attached comprising from 0 to 2 additional heteroatoms selected from N, O, or S; wherein, R 1 is a group other than a group of the following formula: and further wherein, R 1 is a group of the following formula: