Patent ID: 7030153

Claim:
A compound of Formula I: wherein Y is S; wherein X is one or more substituents selected from a) hydrido, halo, cyano, nitro, hydroxy, acyl, lower alkyl substituted at a substitutable position with a substituent selected from halo, hydroxyl, amino, acylamino, lower alkylamino, lower alkyl(acyl)amino, acyl, aryl optionally substituted with hydroxyl, a heterocyclic group, hydroxyimine and lower alkoxyimino, lower alkenyl optionally substituted at a substitutable position with cyano, amino optionally substituted at a substitutable position with a radical selected from acyl and lower alkylsulfonyl, sulfo, sulfamoyl optionally substituted with a substituent selected from the group consisting of lower alkyl, halo(lower)alkyl, aryl, hydroxyl, lower alkylamino(lower)alkyl, a heterocyclic group and (esterified carboxy)lower alkyl, N-containing heterocyclicsulfonyl, a heterocyclic group optionally substituted at a substitutable position with a substituent selected from the group consisting of hydroxyl, oxo, amino and lower alkylamino, b) S(O) n R 5 , wherein R 5 is C 1 -C 7 alkyl optionally substituted at a substitutable position with fluoro, and n is 0, 1 or 2, c) C(R 6 ) (OR 8 ) (R 7 ) wherein R 6 and R 7 independently are selected from CF 3 , CF 2 H, CFCl 2 , CF 2 Cl, CClFH, CCl 2 F, CF 3 CF 2 and C 1 -C 2 alkyl, and wherein R 8 is selected from hydrido, C 1 -C 4 alkyl, (C 1 -C 3 alkyl)C(O) and CO 2 R 9 , wherein R 9 is C 1 -C 4 alkyl, d) C(O)ZR 4 , wherein Z is O, N, or S, and R 4 is selected from hydrido, C 1 -C 6 alkyl and aryl, and when Z is N then R4 is independently taken twice, and e) C(R 9 ) (NHR 11 ) (R 10 ), wherein R 9 and R 10 are independently selected from CF 3 , CF 2 H, CFCl 2 , CF 2 Cl, CClFH and CCl 2 H, and R 11 is selected from hydrido and C 1 -C 3 alkyl; and wherein R 2 and R 3 are independently selected from aryl or heteroaryl, wherein the aryl or heteroaryl radical is optionally substituted at a substitutable position with a radical selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amide, amino, lower alkylamino, sulfamyl and lower alkylsulfonylamino; provided that at least one of R 2 or R 3 is substituted with lower alkylsulfonyl or sulfamyl; or a pharmaceutically-acceptable salt thereof.