Patent ID: 8163709

Claim:
A method of inducing apoptosis and/or cell cycle arrest in a lung cancer cell that expresses Tak1-D comprising contacting said cell with a double-stranded (ds) RNA directed to an mRNA for TLK1, wherein said dsRNA has the sequence NC(A/U)(A/U)(A/U)(A/U)GAX 4-6 AUGAN, wherein in N is any base or null and X is any base, GGCUUUUGACCUUUAUGAA (SEQ ID NO: 1), CCAAAAGAAGAUGUGAUGA (SEQ ID NO:6), 5′-GGCUUUUGACCUUUAUGAAU-U (SEQ ID NO:7) or 3′-CCGAAAACUGGAAAUACUUA-A (SEQ ID NO:8).