Patent ID: 8703139

Claim:
A method for stimulating the appetite of a mammal having a reduced appetite, comprising administering to the mammal having reduced appetite, an isolated monoclonal antibody or binding fragment thereof that binds to the N-terminus of the melanocortin-4 receptor and wherein said isolated monoclonal antibody or binding fragment thereof comprises amino acid sequences set forth in SEQ ID NO:5 and/or SEQ ID NO:7, or amino acids 24 to 31 of SEQ ID NO:5, amino acids 49 to 56 of SEQ ID NO: 5, amino acids 94 to 107 of SEQ ID NO: 5, amino acids 24 to 34 of SEQ ID NO: 7, amino acids 50 to 57 of SEQ ID NO: 7 and amino acids 89 to 97 of SEQ ID NO: 7.