Patent ID: 7504513

Claim:
A compound of formula (1) that inhibits the activity of the enzyme PLK1 wherein: n is 1 or 2; Q 2 is lower alkoxy; R1 is selected from the group consisting of —C(O)OH and heterocyclyl; and R2 is aryl optionally substituted with one or more substituents independently selected from the group consisting of halogen, lower alkoxy, lower alkyl, hydroxyl, lower alkenyl, halo-loweralkyl, hydroxy-loweralkyl, and —C(O)NR8R9 wherein R8 and R9 are each independently selected from the group consisting of hydrogen and lower alkyl, wherein two of said optional substituents can, together with the atoms to which they are bound, form a four to six-membered heterocyclic ring containing at least one atom independently selected from the group consisting of oxygen, nitrogen, and sulfur; and pharmaceutically acceptable salts thereof.