Patent ID: 8637484

Claim:
A modified oligonucleotide 20 nucleobases in length targeted to a nucleic acid molecule encoding growth hormone receptor, wherein said modified oligonucleotide consists of a nucleobase sequence recited in SEQ ID NO: 22, 23, 24, 25, 28, 29, 30, 31, 32, 34, 35, 37, 40, 44, 45, 48, 51, 52, 54, 55, 56, 57, 58, 60, 61, 62, 63, 64, 66, 67, 68, 69, 71, 73, 74, 75, 76, 79, 81, 82, 84, 85, 87, 88, 89, 91, 92, or 94; wherein said modified oligonucleotide consists of a ten deoxynucleotide region flanked on both the 5′ and 3′ end of said ten deoxynucleotide region with five 2′-O-(2-methoxyethyl) nucleotides, wherein each internucleoside linkage in said modified oligonucleotide is a phosphorothioate linkage and each cytosine in said modified oligonucleotide is a 5-methylcytosine; and wherein said modified oligonucleotide inhibits the expression of growth hormone receptor.