Patent ID: 8841289

Claim:
A heterocyclic derivative of formula I wherein R 1 is H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-2 alkyl, Z—C 1-2 alkyl or a 4-8 membered heterocyclyl comprising one or more heteroatomic moiety independently selected from O, S, SO and SO 2 , wherein Z is a 5-6 membered heteroaryl comprising one or more heteroatom independently selected from O, N, and S, said C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-2 alkyl, 5-6 membered heteroaryl and 4-8 membered heterocyclyl being optionally substituted with one or more substituent independently selected from halogen, hydroxyl, C 1-6 alkoxyl, CONR 3 R 4 , SO 2 NR 5 R 6 and CO 2 C 1-6 alkyl; R 2 is H, C 1-8 alkyl, C 3-8 cycloalkyl or C 3-8 cycloalkylC 1-2 alkyl, said C 1-8 alkyl, C 3-8 cycloalkyl and C 3-8 cycloalkylC 1-2 alkyl being optionally substituted with one or more substituent independently selected from halogen, hydroxyl and methoxy or R 2 is C 6-10 aryl optionally substituted with one or more substituent independently selected from halogen, hydroxy, cyano, C 1-8 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy and C 3-6 cycloalkyloxy, said C 1-8 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy and C 3-6 cycloalkyloxy being optionally substituted with one or more halogens or R 2 is a 5-10 membered heteroaryl ring system comprising a heteroatom selected from N, O and S and optionally substituted with methyl, C 1-6 alkyloxy, halogen or cyano; R 3 and R 4 are independently H or C 1-6 alkyl or R 3 and R 4 together with the N to which they are bonded form a 4-7 membered heterocyclic ring optionally comprising a further heteroatomic moiety selected from 0, S, SO and SO 2 , said C 1-6 alkyl and 4-7 membered heterocyclic ring being optionally substituted with one or more halogens; R 5 and R 6 are independently H or C 1-6 alkyl or R 5 and R 6 together with the N to which they are bonded form a 4-7 membered heterocyclic ring optionally comprising a further heteroatomic moiety selected from 0, S, SO and SO 2 , said C 1-6 alkyl and 4-7 membered heterocyclic ring being optionally substituted with one or more halogens; X 1 is CO; X 2 is N; is a moiety selected from: R 7 is (Y) m R 8 , wherein Y is O, NR 9 or CR 10 R 11 , m is 0 or 1, and R 8 is a moiety selected from the group consisting of: wherein a, b and c are independently 1 or 2; wherein d, e and f are independently 1 or 2; wherein g, h and i are independently 1 or 2; wherein j, and k are independently 1 or 2; wherein l, and o are independently 1 or 2; and wherein w, x, y and z are independently 1 or 2; R 9 is H or C 1-6 alkyl; R 10 and R 11 are independently H or C 1-6 alkyl; R 12 and R 13 are independently H, C 1-6 alkyl or oxo; R 14 is a further optional substituent selected from methyl, halogen and cyano; n is 0 or 1, and p is 0 or 1, with the proviso that when R 7 is 1,4-diazabicyclo[3.2.2]non-4-yl or octahydropyrrolo[1,2-a]pyrazin-2-yl, one or both of R 3 and R 4 cannot be H, or a pharmaceutically acceptable salt thereof.