Patent ID: 7868046

Claim:
A method for the treatment of melanoma that involve CXCL1 induced human PMNs chemotaxis said method comprising administering to a subject in need thereof an effective amount of (2R)-phenylpropanamidederivatives of formula (I): R is selected from —H, OH, C 1 -C 5 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 5 -alkenyl, C 1 -C 5 -alkoxy and phenyl; an heteroaryl group selected from substituted and unsubstituted pyrrole, thiophene, furane, indole, imidazole, thiazole, oxazole, pyridine and pirimidine; a residue of formula —CH 2 —CH 2 —O—(CH 2 —CH 2 O)nR″, wherein R″ is H or C 1 -C 5 -alkyl, n is an integer from 0 to 2; or R, together with the NH group to which is coupled, is a radical group of primary amides of natural amino acids such as (2S)-2-aminopropanamide, (2S)-2-amino-3-phenylpropanamide, (2S)-2-amino-3-hydroxypropanamide, (2S)-2-amino-3-carboxypropanamide, (2S)-2,6-diaminoexanamide; R′ is selected from linear or branched C 1 -C 5 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 5 -alkenyl and trifluoromethyl; substituted or unsubstituted phenyl; substituted or unsubstituted benzyl; an heteroaryl group selected from substituted and unsubstituted pyridine, pirimidine, pyrrole, thiophene, furane, indole, thiazole and oxazole.