Patent ID: 7329659

Claim:
A compound of formula (I): wherein Ar is phenyl, a six-membered heteroaromatic group containing one, two or three nitrogen atoms or a five-membered heteroaromatic group containing one, two, three or four heteroatoms chosen from oxygen, nitrogen and sulfur, at most one heteroatom being oxygen or sulfur, Ar being optionally substituted with one, two or three groups independently chosen from halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, amino, haloC 1-6 alkyl, haloC 2-6 alkenyl, haloC 2-6 alkynyl, hydroxyC 1-6 alkyl, hydroxyC 2-6 alkenyl, hydroxyC 2-6 alkynyl, cyano, nitro, aminoC 1-6 alkyl, aminoC 2-6 alkenyl, aminoC 2-6 alkynyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfinyl, C 1-6 alkylthio, C 1-6 alkoxycarbonyl, haloC 1-6 alkoxy, haloC 2-6 alkenyloxy, haloC 2-6 alkynyloxy, NR 4 R 5 , CONR 4 R 5 or CO 2 NR 4 R 5 where each R 4 and R 5 is independently hydrogen or C 1-6 alkyl; R 1 is phenyl, a six-membered heteroaromatic group containing one, two or three nitrogen atoms or a five-membered heteroaromatic group containing one, two, three or four heteroatoms chosen from oxygen, nitrogen and sulfur, at most one heteroatom being oxygen or sulfur, Ar being optionally substituted with one, two or three groups independently chosen from halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, amino, haloC 1-6 alkyl, haloC 2-6 alkenyl, haloC 2-6 alkynyl, hydroxyC 1-6 alkyl, hydroxyC 2-6 alkenyl, hydroxyC 2-6 alkynyl, cyano, nitro, aminoC 1-6 alkyl, aminoC 2-6 alkenyl, aminoC 2-6 alkynyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfinyl, C 1-6 alkylthio, C 1-6 alkoxycarbonyl, haloC 1-6 alkoxy, haloC 2-6 alkenyloxy, haloC 2-6 alkynyloxy, NR 4 R 5 , CONR 4 R 5 or CO 2 NR 4 R 5 where R 4 and R 5 are as defined above; R 2 is hydrogen, halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, NR 6 R 7 where R 6 and R 7 are, independently, hydrogen, C 1-6 alkyl or C 1-6 hydroxyalkyl, or R 6 and R 7 , together with the nitrogen atom to which they are attached form a 4, 5 or 6-membered stable heterocycle optionally containing an oxygen ring atom; R 3 is hydrogen or C 1-6 alkyl; one X, Y and Z is N and the other two are CR 8 where R 8 is hydrogen, halogen or C 1-6 alkyl; or a pharmaceutically acceptable salt thereof.