Patent ID: 7798639

Claim:
A method for producing a medical device having a core material and a lubricious coating, comprising the steps of: (a) contacting the core material with a solution of a polyionic material to form a layer of the polyionic material; wherein the polyionic material is a polymeric material that has a plurality of charged groups; (b) optionally rinsing said medical device by contacting said medical device with a first rinsing solution; (c) contacting said medical device with a solution of a lubricious coating material to form a layer of the lubricious material on top of the layer of the polyionic material, wherein the lubricious material is non-covalently bond to the first polymeric material and is selected from the group consisting of PAMAM dendrimers, PAAm-co-PAA, glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextranes, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides; (d) optionally rinsing said medical device by contacting said medical device with a second rinsing solution; (e) contacting said medical device, which comprises the layer of the polyionic material and the layer of the lubricious material, with a solution of a polyvinylpyrrolidone material to form a capping layer onto said medical device; and (f) optionally rinsing said medical device by contacting said medical device with a third rinsing solution; whereby to obtain the lubricious coating characterized by having an average contact angle of about 80 degrees or less.