Patent ID: 7626022

Claim:
β-heteroaryl-α-alanine compounds of the structural formula I, wherein Y′ and Y″ together form a chain wherein X 1 is nitrogen or a CR 3 group, X 2 is nitrogen or a CR 4 group, R 1 , R 2 , R 3 , and R 4 are the same or different and each independently is selected from the group consisting of hydrogen, halogen, a C 1-3 alkyl residue, a C 1-3 alkoxy residue, a CF 3 residue, a CHF 2 residue, and a CH 2 F residue, R is an alkoxycarbonyl residue selected from the group consisting of tert-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, methyloxycarbonyl, ethyloxycarbonyl, allyloxycarbonyl, benzyloxycarbonyl, 9-(2,7-dibromo)-fluorenylmethyloxycarbonyl, 9-[2,7-bis(trimethylsilyl)9-fluorenylmethyloxycarbonyl, 9-(2,6-di-tert-butyl)-fluorenylmethyloxycarbonyl, 9-(2,7-di-tert-butyl)-fluorenylmethyloxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, 2-trimethylsilylethyloxycarbonyl, p-methoxybenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, 4-methysulfinylbenzyloxycarbonyl, and 6-nitroveratryloxycarbonyl residues or an acyl residue selected from the group consisting of acetyl, trifluoroacetyl, propionyl, pivaloyl, 4-pentenoyl, 2,2-dimethyl-4-pentenoyl, benzoyl, and phthalyl residues, R 5 is a hydrogen atom or a CO 2 X″ group in which X″ represents an alkyl, aryl, or amino group —NR 6 R 7 in which R 6 and R 7 are the same or different and each independently represents a hydrogen, an alkyl or aryl residue and, X′ is an alkyl group selected from the group consisting of methyl, ethyl, propyl, butyl, benzyl, aryl-substituted benzyl, trimethysilyethyl, tert-butyl-neopentyl 2,2,2,-trichloroethyl residues, or diastereomers, enantiomers or mixtures thereof, or free bases, salts, or solutions thereof.