Patent ID: 8680279

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt or ester thereof: wherein: Ar 1 and Ar 2 are independently substituted or unsubstituted aryl; m, n, p and q are each independently 0, 1 or 2; A is a bond, CH 2 , CH═CH, C≡C, NR, O or S; Each R 3 is independently selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, —OH, O-alkyl, O-aryl, —SH, —S-alkyl, fluoro, chloro, bromo, iodo, nitro, or cyano; Q is selected from CH 2 , CHR, CR 2 , NH, NR, O and S; Each Y is independently CR 2 or CR 2 CR 2 ; each R is independently selected from H, OH or alkyl, in particular C 1-4 alkyl; X is O or S; and Z is OH, NR 6 R 7 , NR 8 SO 2 (C 1 -C 6 alkyl), NR 8 C(O)NR 6 R 7 , NR 8 C(S)NR 6 R 7 , NR 8 CHO, NR 8 C(O)(C 1 -C 6 alkyl), NR 8 C(O)O(C 1 -C 6 alkyl), NR 8 -dihydrothiazole, or NR 8 -dihydroimidazole wherein each R 6 , R 7 and R 8 is independently H, C 1 -C 6 alkyl or C 6 -C 12 aralkyl or Z comes together with Ar 2 to form a heterocyclic ring wherein X 2 is —O—, —S—, —N(H)—, —N(R)—, —NH—CH 2 —, —N═CH—, —NR—CH 2 —, —CH 2 —N(H)—, —CH 2 —N(R)—, —CH 2 —, —CH 2 —CH 2 —, —CH═CH—, —CR—CH 2 —, or —CR═CH—; or Z comes together with Ar 2 to form a heterocyclic ring selected from: wherein R 9 and R 10 are each independently H, C 1 -C 6 alkyl or aralkyl.