Patent ID: 7465555

Claim:
A method of detecting early sepsis in a patient, wherein said method comprising the steps of: a) monitoring expression of markers comprising neutrophil-associated CD11b, neutrophil-associated CD64, and monocyte-associated HLA-DR over a period of time; b) independently deriving marker statistics comprising a maximum of said neutrophil-associated CD11b expression, a maximum of said neutrophil-associated CD64 expression, and minimum of said monocyte-associated HLA-DR expression; and c) applying a decision rule to the marker statistics from step (b) to detect early sepsis in said patient; wherein said decision rule is a classification tree that detects early sepsis if a sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a first threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a second threshold value; or said decision rule is a classification tree that detects early sepsis if a sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a third threshold value, and said maximum of said neutrophil-associated CD64 expression is greater than a fourth threshold value; or a sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is less than said third threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a fifth threshold value.