Patent ID: 7279038

Claim:
A method of making a calcium phosphate cement comprising: contacting a composition comprising at least one calcium phosphate compound wherein at least one calcium phosphate compound is Ca 4 (PO 4 ) 2 O, CaHPO 4 .2H 2 O, CaHPO 4 , Ca 8 H 2 (PO 4 ) 6 .5H 2 O, alpha-Ca 3 (PO 4 ) 2 , beta-Ca 3 (PO 4 ) 2 , Ca 2 P 2 O 7 , or Ca 2 H 2 P 2 O 8 with a wetting liquid, wherein the wetting liquid is an acidic aqueous solution, substantially pure water, or ethanol to form a mixture, wherein the ratio of calcium phosphate compound to wetting liquid is less than 10 g/ml; heating the mixture to a temperature between about 50° C. to about 1000° C.; forming calcium phosphate cement particles from the heated mixture; and contacting the calcium phosphate cement particles with a volume of setting liquid that is sufficient to form an injectable paste; wherein one or more of the wetting liquid, the setting liquid and/or the temperature that the mixture is heated to are selected such that the paste has a setting time in the range of 2.5 minutes to 52 minutes.