Patent ID: 7232879

Claim:
A Glucagon Like Peptide-1 GLP-1 analog comprising a valine substitution for alanine at position 8 of GLP-1 (7-36) NH 2 or GLP-1 (7-37) and further comprising one or more amino acid additions or deletions, to GLP-1 (7-36) NH 2 or GLP-1 (7-37) providing that the GLP-1 analog is not found in the formula: R1-X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Y-Gly-Gln-Ala-Ala-Lys-Z-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-R2 wherein: R1 is selected from the group consisting of L-histidine, D-histidine, desamino-histidine, 2-amino-histidine, -hydroxy-histidine, homohistidine, alpha-fluoromethyl-histidine, and alpha-methyl-histidine; X is Val; Y is selected from the group consisting of Glu, Gln, Ala, Thr, Ser, and Gly; Z is selected from the group consisting of Glu, Gln, Ala, Thr, Ser, and Gly; R2 is selected from the group consisting of NH2, and Gly-OH and further providing that the GLP-1 analog demonstrates insulinotropic activity.