Patent ID: 7288267

Claim:
A stable bioadhesive nanoparticulate composition which adsorbs to a biological surface and which comprises: (a) active agent particles in a crystalline state, wherein the active agent particles have an effective average particle size of less than about 4000 nm; and (b) adsorbed to the surface thereof at least one cationic surface stabilizer selected from the group consisting of a polymer, a biopolymer, a polysaccharide, a cellulosic, an alginate, and a nonpolymeric compound, wherein: (i) the nonpolymeric compound is not benzalkonium chloride; and (ii) the composition does not comprise a phospholipid; and (c) wherein the cationic surface stabilizer is in an amount effective to cause nanoparticles of the stable bioadhesive nanoparticulate composition to adhere to a biological surface.