Patent ID: 8389794

Claim:
A genetically modified pig as a model for studying Alzheimer's disease, wherein the genome of the modified pig comprises at least one modified gene or combination of modified genes selected from i) human APP gene or an Alzheimer's disease phenotype causing part thereof, ii) human PS1 gene or an Alzheimer's disease phenotype causing part thereof, iii) porcine APP gene or an Alzheimer's disease phenotype causing part thereof, iv) porcine PS1 gene or an Alzheimer's disease phenotype causing part thereof, v) APP gene or an Alzheimer's disease phenotype causing part thereof and at least one PS1 gene or an Alzheimer's disease phenotype causing part thereof, vi) human APP gene comprising a Swedish mutation or an Alzheimer's disease phenotype causing part thereof comprising a Swedish mutation, vii) human APP gene comprising the APPsw695 gene or an Alzheimer's disease phenotype causing part thereof comprising an APPsw695mutation, viii) human PS1 gene encoding a PS1 protein harbouring a Pro117Leu mutation, or an Alzheimer's disease phenotype causing part thereof comprising a mutation encoding a PSi protein harbouring a Pro117Leu mutation, ix) human APP gene encoding a Swedish mutation or an Alzheimer's disease phenotype causing part thereof comprising a Swedish mutation and at least one modified PS1gene encoding a PS1 protein harbouring a Pro117Leu mutation or an Alzheimer's disease phenotype causing part thereof comprising a mutation encoding a PS1 protein harbouring a Pro117Leu mutation, and x) human APP gene comprising the APPsw695 gene or an Alzheimer's disease phenotype causing part thereof comprising an APPsw695 mutation, and at least one human PS1 gene encoding a PS1 protein harbouring a Pro117Leu mutation or an Alzheimer's disease phenotype causing part thereof comprising a mutation encoding a PS1 protein harbouring a Pro117Leu mutation, and wherein the modified pig expresses at least one phenotype associated with Alzheimer's disease.