Patent ID: 8420374

Claim:
An oral vaccine comprising a live attenuated Helicobacter pylori cell that chronically colonizes the mucosa of a mammal upon oral administration, said Helicobacter pylori cell being transformed with a nucleic acid molecule comprising: (i) at least one non- Helicobacter sequence encoding a non- Helicobacter immunogen of interest linked to a secretory signal peptide; and (ii) a regulatory sequence capable of controlling expression of the non- Helicobacter sequence in the Helicobacter pylori cell, wherein the Helicobacter pylori cell is not a DapE mutant strain; wherein upon oral administration of said Helicobacter pylori cell, it chronically colonizes the mucosa and the non- Helicobacter sequence encoding a non- Helicobacter immunogen of interest is expressed in sufficient quantities to elicit an immunologically detectable response against said non- Helicobacter immunogen of interest.