Patent ID: 7919455

Claim:
A peptide labeled with fluorine-18 comprising: a peptide sequence (PI) described by SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14, wherein said peptide is labeled with a compound (CI) of general formula: in which: m represents an integer from 0 to 10; n represents an integer from 0 to 10; Y represents a group selected from the group consisting of alkyl, imidazolyl, pyrazolyl, benzimidazolyl, pyridinyl, piridazinyl, pyrimidinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, quinoxalinyl, and purinyl, wherein Y may be optionally substituted with one or more substituents selected independently from the group consisting of hydrogen, non-radioactive halogen, phenyl, C 1-6 alkyl, C 1-6 alkoxy, aryloxy, amino, mono- or di(C 1-6 alkyl)amino, mono- or di(aryl)amino, thio, C 1-6 alkylthio, arylthio, formyl, C 1-6 alkylcarbonyl, arylcarbonyl, carbonyl, C 1-6 alkoxycarbonyl, aryloxycarbonyl, C 1-6 alkylaminocarbonyl, arylaminocarbonyl and trifluoromethyl groups; β represents a radical of formula: (γ) a -((CR 1 R 2 ) b —(V) c ) d —((CR 3 R 4 ) e —(W) f ) g — in which: a, b, c, d, e, f, g each independently represent an integer from 0 to 10; γ, V and W each independently represent —NR— 1 , —O—, —S—, ethynyl, —CR 1 ═CR 2 , —(C═O)—, —(C═S)—, —C(═NR 1 )—, —C(═O)O—, —(C═S)S—, —C(═NR 1 )NR 2 —, —CR 1 R 2 —, —CR 1 OR 2 —, —CR 1 NR 2 R 3 —, where R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, phenyl, C 1-6 alkyl, C 1-6 alkoxy, aryloxy, amino, mono- or di(C 1-6 alkyl)amino, mono- or di(aryl)amino, thio, C 1-6 alkylthio, arylthio, formyl, C 1-6 alkylcarbonyl, arylcarbonyl, carbonyl (C 1-6 )alkoxycarbonyl, aryloxycarbonyl, C 1-6 alkylaminocarbonyl, arylaminocarbonyl, and trifluoromethyl groups; wherein compound (CI) is bound on an —SH group of said peptide.