Patent ID: 8658618

Claim:
A method for minimizing neurotoxicity associated with treating a cancer patient with a combination comprising a DPD inhibitor and an anticancer agent selected from 5-FU or a 5-FU prodrug, comprising first administering a DPD inhibitor at a dose sufficient to substantially eliminate DPD activity in both nervous and non-nervous tissues, wherein the DPD inhibitor is eniluracil and is administered at a dose of 50 mg, and thereafter administering the 5-FU or 5-FU prodrug, wherein the 5-FU or 5-FU prodrug is administered at a dose such that the 5-FU or 5-FU generated from the 5-FU prodrug is present in the patient in at least 5-fold excess of the DPD inhibitor and at a time when 3-5 elimination half-lives for the DPD inhibitor have passed since the DPD inhibitor was administered.