Patent ID: 8603458

Claim:
A method for modulating an immune response, comprising administering host cells and an antigen to a mammal, wherein the host cells have been obtained from the mammal and have been genetically modified with an expression vector to produce, or increase production of, p35 and p40 subunits of IL-12, and IFN-γ, by the host cells, wherein the expression vector comprises a nucleic acid encoding the p35 and p40 subunits of IL-12 and IFN-γ operably linked to a promoter, wherein the p35 and p40 subunits of IL-12 and IFN-γ are secreted by the administered host cells in the mammal, and wherein said administering of the host cells and the antigen result in an increase of IFN-γ and IL-2 production, an increase of IgG2a specific to the antigen, a decrease of IL-4 production, and reduced serum IgE in the mammal.