Patent ID: 6947844

Claim:
A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of: (a) providing a molecular model comprising one or more target regions selected from the group consisting of the peptidyl transferase site, the A-site, the P-site, the E-site, the elongation factor binding domain, the polypeptide exit tunnel, and the signal recognition particle (SRP) binding domain, from the atomic co-ordinates for Haloarcula marismortui large ribosomal subunit found on Disk 1 under file names 1ffk.doc or 1ffk.ent or on Disk 2 under file names 1jj2rtf or 1jj2.txt, or a large ribosomal subunit derived from said Haloarcula marismortui atomic co-ordinates by molecular modeling; (b) using the molecular model to identify a candidate molecule that can bind to said one or more target regions in the molecular model; and (c) producing the candidate molecule identified in step (b).