Patent ID: 7038041

Claim:
An estrogen/anti-estrogen-porphyrin conjugate having the structure: wherein R 1 ═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20, R 2 ,R 3 ═H; or R 1 ═X—Y—(CH 2 ) n —Y—X—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20, R 2 ,R 3 ═H; or R 1 =Z-(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S); Z=C≡C, C═CH, CH 2 —CH 2 , n=1–20, R 2 ,R 3 ═H; or R 2 ═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20, R 1 ,R 3 ═H; or R 2 ═X—Y—(CH 2 ) n —Y—X—P, where X═O, NH, S; Y═(═O), C(═S), n=1–20, R 1 ,R 3 ═H; or R 2 =Z-(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S); Z=C≡C, C═CH, CH 2 —CH 2 , n=1–20, R 1 ,R 3 ═H; or R 3 ═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20, R 1 ,R 2 ═H; or R 3 ═X—Y—(CH 2 ) n —Y—X—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20, R 1 ,R 2 ═H; or R 3 =Z—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═(═O), C(═S); Z=C≡C, C═CH, CH 2 —CH 2 , n=1–20, R 1 ,R 2 ═H; or the structure: wherein R 1 ═O—(CH 2 ) 2 —N(CH 3 ) 2 , R 2 ═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═CH 2 , C(═O), C(═S), n=1–20; or R 1 ═O—(CH 2 ) 2 —N (CH 3 ) 2 , R 2 ═X—Y—(CH 2 ) n —Y—X—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20; or R 1 ═O—(CH 2 ) 2 —N (CH 3 ) 2 , R 2 =Z-(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S); Z=C≡C, C═CH, CH 2 —CH 2 , n=1–20; or R 1 ═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═CH 2 , C(═O), C(═S), n=1–20, R 2 ═H, OH; or R 1 ═X—Y—(CH 2 ) n —Y—X—P, where X═O, NH, S; Y═C(═O), C(═S), n=1–20, R 2 ═H, OH; or R 1 =Z-(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═(═O), C(═S); Z=C≡C, C═CH, CH 2 —CH 2 , n=1–20, R 2 ═H, OH; or R 1 ═O—(CH 2 ) 2 —N(CH 2 —W)CH 3 , where W═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═CH 2 , C(═O), C(═S), n=1–20, R 2 ═H, OH; or R 1 ═O—(CH 2 ) 2 —N(CH 2 —W)CH 3 , where W═X—Y—(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═CH 2 , C(═O), C(═S), n=1–20, R 2 ═H, OH; or R 1 ═O—(CH 2 ) 2 —N(CH 2 —W)CH 3 , where W=Z-(CH 2 ) n —X—Y—P, where X═O, NH, S; Y═C(═O), C(═S); Z=C≡C, C═CH, CH 2 —CH 2 , n=1–20, R 2 ═H, OH, and wherein, for either said structure, P=a natural or synthetic porphyrin.