Patent ID: 8440646

Claim:
A method for treating a bacillus anthracis infection in a subject, comprising administering to said subject an effective amount of a substituted tetracycline compound, such that said bacillus anthracis infection in said subject is treated, wherein said substituted tetracycline compound is of the formula I: wherein R 2″ is C(═O)—NR 2 R 2′ ; R 2 , R 2′ , and R 3 are hydrogen; R 4a and R 4b are each alkyl; R 10 , R 11 , and R 12 are each hydrogen; R 4 and R 4′ are each independently NR 4a R 4b or hydrogen; R 5 and R 5′ are each hydrogen; R 6 and R 6′ are each hydrogen; R 7 is hydrogen, dialkylamino, alkyl, aryl, heterocyclic, or alkyl-O—N═C—CR 7g R 7h , wherein R 7g and R 7h are each independently hydrogen or alkyl; R 8 is hydrogen; R 9 is of the formula: wherein: J 5 and J 6 are each independently hydrogen, alkyl, alkenyl, or linked to form a ring; and J 7 and J 8 are each alkyl, halogen, or hydrogen; and X is CR 6′ R 6 ; or a pharmaceutically acceptable salt, ester or enantiomer thereof.