Patent ID: 7122679

Claim:
A compound of formula Ia: wherein: each of A and B is, independently, C(═O), CH(OR 3 ), CH(SR 3 ), CH 2 , CHR 3 , CHR 3 CHR 4 , CR 3 R 4 , C(═O)NR 3 , SO, or SO 2 ; Y and Z, together with the carbon atoms to which they are attached, form: a substituted or unsubstituted aryl group, wherein said aryl group is monocyclic or bicyclic and said substituted aryl group has at least one substituent J; a substituted or unsubstituted bicyclic heteroaryl group, wherein said substituted bicyclic heteroaryl group has at least one substituent J; or a C 3 to C 5 heteroaryl group; E and F, together with the atoms to which they are attached, form: a substituted or unsubstituted C 4 to C 7 cycloalkyl group, wherein said substituted cycloalkyl group has at least one substituent J; R 2 is: hydrogen, lower alkyl, lower alkyl having at least one substituent J, formyl, acetyl, lower alkanoyl, lower alkanoyl having at least one substituent J, lower alkylsulfonyl, arylsulfonyl, an amino acid, or a protected amino acid; each of R 3 and R 4 is, independently, hydrogen, lower alkyl, aryl, lower alkyl having at least one substituent J, or aryl having at least one substituent J; J is: J 3 -(J 2 ) n -(J 1 ) m wherein each of n and m is, independently, 0 or 1; each of J 1 and J 2 is, independently, carbonyl, lower alkylcarbonyl, arylcarbonyl, carbonyloxy, sulfonyl, amino, lower alkylamino, lower dialkylamino, amido, lower alkylamido, lower dialkylamido, lower alkyloxycarbonylamino, aryloxycarbonylamino, amidino, guanidino, lower alkoxy, lower aryloxy, aralkoxy, lower alkyl, C 3 to C 7 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, sulfonylamido, alkylsulfonylamido, arylsulfonylamido, an amino acid, a protected amino acid, aminocarbonyloxy, arylaminocarbonyloxy, or heteroarylaminocarbonyloxy; and J 3 is: hydrogen, halo, hydroxy, thio, cyano, sulfonic acid, carboxyl, lower alkyl, aryloxycarbonyl, alkyloxycarbonyl, phosphonic acid, lower alkyl ester of phosphonic acid, aryl ester of phosphonic acid, aminocarbonyloxy, heteroaryl, or heterocycloalkyl; and any two adjacent J groups can combine to form —X—(CH 2 ) p —X—, wherein X is independently O or NH, and p is 1 or 2.