Patent ID: 7335776

Claim:
A method for the treatment of depression, comprising administering to a subject in need thereof an effective amount of EP 1 antagonist, wherein EP 1 antagonist is N-arylsulfonylamide compound of formula (IK) wherein R 1K is COOH, hydroxymethyl, 5-tetrazolyl, 5-oxo-1,2,4-oxadiazolyl or 5-oxo-1,2,4-thiadiazolyl, R 2K is hydrogen, methyl, methoxy or chloro, R 3K and R 4K are a combination of (1) methyl and methyl, (2) methyl and chloro, (3) chloro and methyl, or (4) trifluoromethyl and hydrogen; or R 3 and R 4 are taken together with the carbon to which R 3 and R 4 are attached to form (5) cyclopentene, (6) cyclohexene or (7) benzene ring, R 5K is isopropyl, isobutyl, 2-methyl-2-propenyl, cyclopropylmethyl, methyl, ethyl, propyl, 2-propenyl or 2-hydroxy-2-methylpropyl, Ar k is thiazolyl optionally substituted with methyl, pyridyl or 5-methyl-2-furyl, n K is 0 or 1, with the proviso that n is 0 when R 1K is 5-tetrazolyl, 5-oxo-1,2,4-oxadiazolyl or 5-oxo-1,2,4-thiadiazolyl, an alkyl ester thereof or a non-toxic salt thereof.