Patent ID: 7317007

Claim:
A compound of formula IA wherein R 1 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, cycloalkyloxy, halogen, hydroxy or trifluoromethyloxy; R 2 , R 3 are independently from each other hydrogen, halogen, lower alkyl or lower alkyloxy; R 4 is morpholino, which may be attached to the benzo group via the linker —(O) m —(CH 2 ) n or —N═C(CH3)— and is unsubstituted or substituted by one or two group(s) R 7 , wherein R 7 is defined below; R′ is (CH 2 ) n -piperidine which is unsubstituted or substituted by 2-oxo-pyrrolidin, piperidinyl, phenyl, —(CH 2 ) n OH, halogen, CF 3 , ═O, lower alkyl, cycloalkyl, —(CH 2 ) n —O—-lower alkyl, —(CH 2 ) n NH 2 , —(CH 2 ) n CH, —C(O)O-lower alkyl, —CH 2 —O—S(O) 2 CH 3 , —C(O)—lower alkyl, —C(O)—(CH 2 ) n -lower alkoxy, —CH 2 —N(R 6 )C 6 H 4 F, —CH 2 —N(R 6 )C(O)O-lower alkyl, —N(R 6 )—C(O)—N(R 5 )—(CH 2 ) n —O-lower alkyl, -or by tetrahydrofuran, substituted by 4-Cl-phenyl, or by piperazin-1-yl, morpholinyl, thiomorpholinyl, thiomorpholin-1-oxo, pyrrolidin-1-yl or by piperidin-1-yl or is benzopiperidin-1-yl or benzothien-2-yl, X is O, S or two hydrogen atoms; R 5 , R 6 are independently from each other hydrogen or lower alkyl, R 7 is lower alkyl, lower alkoxy, —C(O)-lower alkyl, —C(O)O-benzyl, —C(O)O-lower alkyl, —(CH 2 ) n NR 5 R 6 , pyridinyl, unsubstituted or substituted by lower alkyl, or is —CH 2 N(R 5 )—C(O)O-lower alkyl, —NH—C(phenyl)3, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, unsubstituted or substituted by lower alkyl; n is 0, 1, 2, 3 or 4; m is 0 or 1; o is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.