Patent ID: 6878714

Claim:
A compound of formula XIII: wherein R is selected from a) unsubstituted or substituted 5- or 6-membered rings selected from 4-pyridyl, 2-pyridyl, 4-pyrimidinyl, and tetrahydro-2H-pyran-4-yl, and b) unsubstituted or substituted 9- or 10-membered fused rings selected from 4-quinolyl, 6-quinolyl, 2,3-dihydro-5-benzofuryl, 5-benzoxazolyl, 1H-pyrrolo[2,3-b]pyridin-4-yl, and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl, where substituted R is substituted with one or more substituents selected from halo, amino, hydroxy, oxo, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkylaminocarbonyl, C 1-6 -alkoxy, optionally substituted heterocyclyl-C 1-6 -alkoxy, optionally substituted heterocyclyl-C 1-6 -alkylamino, optionally substituted heterocyclyl-C 1-6 -alkyl, C 1-6 -alkylamino-C 2-4 -alkynyl, C 1-6 -alkylamino-C 1-6 -alkoxy, C 1-6 -alkylamino-C 1-6 -alkoxy-C 1-6 -alkoxy, and optionally substituted heterocyclyl-C 2-4 -alkynyl; and wherein R 1 is 4,4-dimethyl-3,4-dihydro-2-oxo-1H-quinolinyl; or wherein R 1 is 4,4-dimethyl-1,2,3,4-tetrahydro-1H-quinolinyl; or wherein R 1 is 4,4-dimethyl-3,4-dihydro-2-oxo-1H-[1,8]naphthyridinyl; or wherein R 1 is 3,3-dimethyl-2,3-dihydro-1H-indolyl optionally substituted with a substituent selected from pyrrolidin-1-yl-carbonyl, methylcarbonyl, and methylsulfonyl; or wherein R 1 is 4,4-dimethyl-1,2,3,4-tetrahydro-1H-isoquinolinyl; or wherein R 1 is 2-oxo-3,3-bis(trifluoromethyl)-2,3-dihydro-1H-indol-6-yl; or wherein R 1 is 1′,2′-dihydro-spiro[cyclopropane-1,3′-[3H]indol]-6′-yl; and pharmaceutically acceptable derivatives thereof.