Patent ID: 7591949

Claim:
A method for controlling the flux of penetrants across an adaptable semi-permeable porous barrier, the method comprising the steps of: preparing a formulation by suspending or dispersing said penetrants in a polar liquid, the penetrants comprising at least two kinds or forms of amphiphilic substances with a tendency to aggregate, wherein said at least two substances differ by at least a factor of 10 in solubility in said polar liquid, and wherein said penetrants are able to transport a drug agent through the pores of said barrier or enable drug agent permeation through the pores of said barrier after the penetrants have entered the pores, the formulation further comprising a thickening agent and having a viscosity that is 0.2 kN s/m 2 to 5 kN s/m 2 ; selecting a dose amount of said penetrants to be applied on a predetermined area of said barrier to control the flux of said penetrants across said barrier; and applying said formulation containing the selected dose amount of said penetrants onto said area of said porous barrier, the formulation having a viscosity that enables retention of the drug agent at the area, and wherein the drug agent is a peptide or a protein.