Patent ID: 8258102

Claim:
A non-naturally occurring polypeptide comprising: (i) a leader sequence, the leader sequence comprising: (a) an albumin secretion pre sequence or albumin secretion pre sequence having at least 90% sequence identity to SEQ ID NO:28, and (b) the following motif: -X 1 -X 2 -X 3 -X 4 -X 5 - where X 1 is phenylalanine, tryptophan, or tyrosine, X 2 is isoleucine, leucine, valine, alanine or methionine, X 3 is leucine, valine, alanine or methionine, X 4 is serine or threonine and X 5 is isoleucine, valine, alanine or methionine; and (ii) a sequence of a mature desired protein.