Patent ID: 8795691

Claim:
A method of promoting osteoblast differentiation and proliferation at a site of a bone injury or defect or bone surgical site comprising providing an implant having a composition including nanotubes formed from modules according to Formula II, nanoparticles, and a matrix material, and optionally nanotubes formed from modules according to Formula I wherein Formula II is wherein X is CH or nitrogen; Y is lysine-arginine-serine-arginine, isoleucine-lysine-valine-alanine-valine or tyrosine-isoleucine-glycine-serine-arginine; R 2 is absent or a linker and R 1 is aliphatic, and wherein Formula I is wherein X is CH or nitrogen; Y is lysine-arginine-serine-arginine, isoleucine-lysine-valine-alanine-valine or tyrosine-isoleucine-glycine-serine-arginine; R 2 is absent or a linker and R 1 is aliphatic, and placing the implant at the site of a bone injury or defect or bone surgical site.