Patent ID: 8575188

Claim:
A compound of Formula I: wherein u is 0 or 1; R 1a , R 1b , and R 1c independently are H, halogen, hydroxyl, nitrile, amino, substituted amino, nitro, carboxyl ester, aminocarbonyl, substituted sulfonyl, aminosulfonyl, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkynyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted C 1 -C 6 alkoxy group, or R 1a and R 1b together with the carbon atoms to which they are bonded form a 5-7 membered heterocycle, or R 1b and R 1c together with the carbon atoms to which they are bonded form a 5-7 membered heterocycle; R 2 is H, halogen, nitrile, formyl, oxime, hydrazone, imine, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted C 2 -C 6 alkenyl, or substituted or unsubstituted C 2 -C 6 alkynyl group; or R 2 and R 1a together with the carbon atoms to which they are attached form a 5-7 membered substituted cycloalkyl ring; X is nitro or —NR 3 R 4 ; each R 3 and R 4 are independently H, substituted or unsubstituted C 1 -C 6 alkyl, —CO 2 R 5 , or —COR 6 ; R 5 is substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 6 is H, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or a carboxyl ester or a pharmaceutically acceptable salt thereof, provided however that the compound is not 14-nitro-20-acetoxycamptothecin.