Patent ID: 7241765

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: V is a bond; W is nitrogen; X is selected from halogen, hydroxy, nitro, and groups of the formula L-M; Y and Z are each CH; n is 1; R 1 and R 2 are each independently selected from hydrogen, halogen, hydroxy, nitro, cyano, and groups of the formula L-M , with the proviso that R 1 and R 2 are not both hydrogen; R 3 is: (i) selected from (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl and halo(C 1 –C 6 )alkyl; or (ii) joined with R 10 to form a carbocyclic ring having from 5 ring members; R 4 is hydrogen, (C 1 –C 6 )alkyl or halo(C 1 –C 6 )alkyl; R 5 is independently selected at each occurrence from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 1 –C 6 )alkoxy, halo(C 1 –C 6 )alkyl, halo(C 1 –C 6 )alkoxy, mono- and di(C 1 –C 6 )alkylamino, and amino(C 1 –C 6 )alkyl; R 6 is selected from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 1 –C 6 )alkoxy, halo(C 1 –C 6 )alkyl, halo(C 1 –C 6 )alkoxy, mono- and di(C 1 –C 6 )alkylamino, and amino(C 1 –C 6 )alkyl; R 7 is selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L-M; R 8 is selected from halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L-M U is CR 9 ; T is CR 10 ; R 9 is selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L-M; R 10 is: (i) selected from hydrogen, halogen, hydroxy, nitro, cyano, —COOH, and groups of the formula L-M; or (ii) joined with R 3 to form a carbocyclic ring having 5 ring members; R 11 is selected from halogen, (C 1 –C 3 )alkyl, and halo(C 1 –C 3 )alkyl; R 12 is selected from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 1 –C 6 )alkoxy, halo(C 1 –C 6 )alkyl, halo(C 1 –C 6 )alkoxy, mono- and di(C 1 –C 6 )alkylamino, and amino(C 1 –C 6 )alkyl; L is a bond, —NR 14 —, —O—, —SO 2 —, or NR 14 C(═O)— wherein R 14 is independently selected at each occurrence from hydrogen, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, and halo(C 1 –C 6 )alkyl; and M is (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, halo(C 1 –C 6 )alkyl, or a 5- to 10-membered carbocycle.