Patent ID: 7635708

Claim:
A method for reducing proliferation of a PPARγ-responsive hyperproliferative cell in a subject in need thereof, comprising contacting the cell with a) a PPARγ agonist represented by the formula: or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof in which A 1 represents a substituted or unsubstituted aromatic heterocyclyl group; R 1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; R 2 and R 3 each represent hydrogen, or R 2 and R 3 together represent a bond; A 2 represents a benzyl or chromanyl moiety having, as valence and stability permit, up to five substituents; and n represents an integer in the range of from 1 to 6 in an amount effective to reduce proliferation of the cell, and b) a second antiproliferative agent, wherein the PPARγ-responsive hyperproliferative cell is selected from the group consisting of an adipose cell, an adipose precursor cell, an adipose tumor cell, a liposarcoma cell, a myeloid cell, a hemopoietic cell, a hemopoietic precursor cell, and a prostate cancer cell.