Patent ID: 7427613

Claim:
A compound of general formula I wherein X and W represent a —CH— group; V represents —(CH 2 ) r ; -A-(CH 2 ) s —; —CH 2 -A-(CH 2 ) t —; —(CH 2 ) s -A-; —(CH 2 ) 2 -A-(CH 2 ) u —; -A-(CH 2 ) v —B—; —CH 2 —CH 2 —CH 2 -A-CH 2 —; -A-CH 2 —CH 2 —B—CH 2 —; —CH 2 -A-CH 2 —CH 2 —B—; —CH 2 —CH 2 —CH 2 -A-CH 2 —CH 2 —; CH 2 —CH 2 —CH 2 —CH 2 -A-CH 2 —; -A-CH 2 —CH 2 —B—CH 2 —CH 2 —; —CH 2 -A-CH 2 —CH 2 —B—CH 2 —; —CH 2 -A-CH 2 —CH 2 —CH 2 —B—; or —CH 2 —CH 2 -A-CH 2 —CH 2 —B—; A and B independently represent —O—; —S—; —SO—; or —SO 2 —; U represents aryl; or heteroaryl; T represents —CONR 1 —; —CH 2 ) p OCO—; —(CH 2 ) p N(R 1 )CO—; —(CH 2 ) p N(R 1 )SO 2 —; or —COO—; Q represents lower alkylene; or lower alkenylene; M represents hydrogen; cycloalkyl; aryl; heterocyclyl; or heteroaryl; L represents —R 3 ; —COR 3 ; —COOR 3 ; —CONR 2 R 3 ; —SO 2 R 3 ; —SO 2 NR 2 R 3 ; or —COCH (Aryl) 2 ; R 1 represents hydrogen; lower alkyl; lower alkenyl; lower alkinyl; cycloalkyl; aryl; or cycloalkyl-lower alkyl; R 2 and R 2 ′, independently represent hydrogen; lower alkyl; lower alkenyl; cycloalkyl; or cycloalkyl-lower alkyl; R 3 represents hydrogen; lower alkyl; lower alkenyl; cycloalkyl; aryl; heteroaryl; heterocyclyl; cycloalkyl-lower alkyl; aryl-lower alkyl; heteroaryl-lower alkyl; heterocyclyl-lower alkyl; aryloxy-lower alkyl; or heteroaryloxy-lower alkyl; wherein these groups may be unsubstituted or mono-, di- or tri-substituted with hydroxy, —OCOR 2 , —COOR 2 , lower alkoxy, cyano, —CONR 2 R 2 ′, —CO-morpholin-4-yl, —CO-((4-lower alkyl)piperazin-1-yl), —NH(NH)NH 2 , —NR 4 R 4 ′, or lower alkyl, with the proviso that a carbon atom is attached at the most to one heteroatom in case this carbon atom is sp3-hybridized; R 4 and R 4 ′ independently represent hydrogen; lower alkyl; cycloalkyl; cycloalkyl-lower alkyl; hydroxyl-lower alkyl; —COOR 2 ; or —CONH 2 ; m represents the integer 1 and n represents the integer 0; p is the integer 1, 2, 3 or 4; r is the integer 3, 4, 5, or 6; s is the integer 2, 3, 4, or 5; t is the integer 1, 2, 3, or 4; u is the integer 1, 2, or 3; and v is the integer 2, 3, or 4; or optically pure enantiomers, mixtures of enantiomers, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates, or the meso-form; or pharmaceutically acceptable salts, of said compound.