Patent ID: 7390485

Claim:
An ADPase enhanced apyrase, which ADPase enhanced apyrase is a modified form of a soluble form of CD39L3 or a fusion protein of said soluble form with heterologous sequence wherein said modification results in increased ADPase activity; or substantially the same ADPase activity combined with decreased ATPase activity as compared with the native apyrase, wherein the enhanced apyrase contains two amino acid substitutions; wherein one of said two amino acid substitutions is either at position 67 or at position 69 of human CD39L3 as set forth in SEQ ID NO: 56 or positions corresponding thereto in an isoenzyme of human CD39L3, wherein said soluble form of human CD39L3 lacks a 43 amino acids sequence from the N-terminus and lacks a 44 amino acid sequence from the C-terminus of SEQ ID NO: 56.