Patent ID: 8796458

Claim:
A method of treating pulmonary hypertension, glaucoma, neuronal degeneration or Alzheimer's disease in a patient comprising administering to said patient an effective amount of at least one compound of the formulae (I) or (I′): wherein R 1 is H; R 2 is H; R 3 is H; R 4 is H, halogen, OH, CN, (C 1 -C 6 )alkyl; R 5 is H, halogen, CN, NO 2 , (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, —NH 2 , NH—SO 2 H, NH—SO 2 —(C 1 -C 6 )alkyl, NH—C(O)—(C 1 -C 6 )alkyl, C(O)N[(C 1 -C 6 )alkyl] 2 , C(O)OH or C(O)O—(C 1 -C 6 )alkyl; R 6 and R 6 ′ are independently of each other H, R′, (C 1 -C 8 )alkyl, (C 1 -C 6 )alkylene-R′, (C 1 -C 6 )alkylene-O—(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylene-O—R′, (C 1 -C 6 )alkylene-CH[R′] 2 , (C 1 -C 6 )alkylene-C(O)—R′, (C 1 -C 6 )alkylene-C(O)NH 2 , (C 1 -C 6 )alkylene-C(O)NH—R′, or (C 1 -C 6 )alkylene-C(O)N[R′] 2 ; R 7 and R 8 are independently of each other H, halogen, CN, NO 2 , (C 1 -C 6 )alkyl, O—(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, NH 2 , NH—SO 2 H, NH—SO 2 —(C 1 -C 6 )alkyl, SO 2 —NH 2 , NH—C(O)—(C 1 -C 6 )alkyl, C(O)N[(C 1 -C 6 )alkyl] 2 , C(O)OH, or C(O)O—(C 1 -C 6 )alkyl; R 9 is halogen or (C 1 -C 6 )alkyl; R′ is (C 3 -C 8 )cycloalkyl, (C 5 -C 10 )heterocyclyl or (C 6 -C 10 )aryl; n is 0; and L is O or O—(C 1 -C 6 )alkylene; wherein in residues R 4 , R 5 , R 7 and R 8 one alkyl or alkylene hydrogen atom can optionally be substituted by OH, OCH 3 , COOH, COOCH 3 , NH 2 , NHCH 3 , N(CH 3 ) 2 , CONH 2 , CONHCH 3 or CON(CH 3 ) 2 , or a pharmaceutically acceptable salt thereof, or a stereoisomeric form thereof, or a pharmaceutically acceptable salt of a stereoisomeric form thereof.