Patent ID: 7514551

Claim:
A composition of matter comprising a nucleic acid strand or a complex of two or more nucleic acid strand wherein said strand or complex comprises one or more reactive groups and two or more labeled nucleotides or labeled nucleotide analogs, wherein said reactive group is isothiocyanate, isocyanate, monochlorotriazine, dichlorotriazine, mono- or di-halogen substituted pyridine, mono- or di-halogen substituted diazine, maleimide, aziridine, sulfonyl halogen substituted diazine, maleimide, aziridine, sulfonyl halide, acid halide, hydroxysuccinimide ester, hydroxysulfosuccinimide ester, imido ester, hydrazine, azidonitrophenyl, azide, 3-(2-pyridyl dithio)-proprionamide, glyoxal, aldehyde, carbon-carbon double bonds, mercury salts, and/or any group capable of reacting with carbon-carbon double bonds, amines, hydroxyl groups, sulfhydryl groups and/or halogens.