Patent ID: 8344114

Claim:
An isolated antibody or antigen-binding fragment thereof that specifically binds to PCSK9 and antagonizes PCSK9-mediated inhibition of cellular LDL uptake and comprises: (a) a heavy chain immunoglobulin variable region polypeptide comprising: a heavy chain CDR1 comprising the amino acid sequence set forth in SEQ ID NO: 81; a heavy chain CDR2 comprising the amino acid sequence set forth in SEQ ID NO: 83; and a heavy chain CDR3 comprising the amino acid sequence set forth in SEQ ID NO: 85; and (b) a light chain immunoglobulin variable region polypeptide comprising a light chain CDR1 comprising the amino acid sequence set forth in SEQ ID NO:71; a light chain CDR2 comprising the amino acid sequence set forth in SEQ ID NO: 73; and a light chain CDR3 comprising the amino acid sequence set forth in SEQ ID NO: 75.