Patent ID: 8420084

Claim:
An isolated monoclonal antibody, or an antigen-binding portion thereof, which binds human CADM1 and which comprises heavy and light chain variable regions, wherein the regions are selected from the group consisting of: (a) a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:19, 20, or 21; (b) a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:22, 23, or 24; (c) a heavy chain variable region CDR1 comprising SEQ ID NO:1, a heavy chain variable region CDR2 comprising SEQ ID NO:4, a heavy chain variable region CDR3 comprising SEQ ID NO:7, a light chain variable region CDR1 comprising SEQ ID NO:10, a light chain variable region CDR2 comprising SEQ ID NO:13 and a light chain variable region CDR3 comprising SEQ ID NO:16; (d) a heavy chain variable region CDR1 comprising SEQ ID NO:2, a heavy chain variable region CDR2 comprising SEQ ID NO:5, a heavy chain variable region CDR3 comprising SEQ ID NO:8, a light chain variable region CDR1 comprising SEQ ID NO:11, a light chain variable region CDR2 comprising SEQ ID NO:14 and a light chain variable region CDR3 comprising SEQ ID NO:17; (e) a heavy chain variable region CDR1 comprising SEQ ID NO:3, a heavy chain variable region CDR2 comprising SEQ ID NO:6, a heavy chain variable region CDR3 comprising SEQ ID NO:9, a light chain variable region CDR1 comprising SEQ ID NO:12, a light chain variable region CDR2 comprising SEQ ID NO:15 and a light chain variable region CDR3 comprising SEQ ID NO:18; (f) heavy and light chain variable regions comprising the amino acid sequences set forth in SEQ ID NOs:19 and 22, respectively; (g) heavy and light chain variable regions comprising the amino acid sequences set forth in SEQ ID NOs:20 and 23, respectively; and (h) heavy and light chain variable regions comprising the amino acid sequences set forth in SEQ ID NOs:21 and 24, respectively.