Patent ID: 8802722

Claim:
A method for inhibiting melanogenesis or a method for promoting skin lightening comprising administering to a mammal an effective amount of a compound of formula I: wherein R 3 is selected from H, halo, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted aryl; and substituted or unsubstituted heteroaryl; R 4 is selected from H, halo, hydroxy, alkoxy, alkenyloxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted phenyl; each R 5 , R 6 , and R 8 is independently selected from H, halo, hydroxy, alkoxy, alkenyloxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted phenyl; R 7 is substituted alkyl, substituted or unsubstituted alkenyl, or heterocycloalkyl; or R 7 is —P(═O)(alkoxy) 2 , or —P(═S)(alkoxy) 2 ; or R 6 and R 7 or R 7 and R 8 are joined to form a 5- or 6-membered heterocycloalkyl or heterocycloalkenyl; and the heterocycloalkyl or heterocycloalkenyl is unsubstituted or substituted with one more groups selected from alkyl, alkenyl, hydroxyalkyl, acyloxyalkyl, hydroxy, and alkoxy; or pharmaceutically acceptable salts, solvates, isomers, tautomers, metabolites, analogs, isotopic variants or prodrugs thereof.