Patent ID: 8173133

Claim:
An immunomodulatory composition comprising N-acyl-dipeptide-like adjuvant bearing an acid group in neutral or charged state, at one end portion of said dipeptide-like adjuvant and bearing an accessory functional side chain spacer at the other end portion thereof, having the general formula I: wherein R 1 and R 2 each designate an acyl group derived from a saturated or unsaturated, straight or branched chain-carboxylic acid having from 2 to 24 carbon atoms, which is unsubstituted or bears one or more substituents selected from a group consisting of hydroxyl, alkyl, alkoxy, acyloxy, amino, acylamino, acylthio and (C 1-24 )alkylthio groups, subscripts m, n are integers ranging from 0 to 10, subscripts p, q are integers ranging from 1 to 10, Y designates O or NH, and wherein one of X or Z designates an acid group either in neutral or charged state selected from the a group consisting of carboxyl, carboxy [(C 1-5 )alkoxy], carboxy [(C 1-5 )alkylthio], phosphono [(C 1-5 )alkoxy], phosphono [(C 1-5 )alkylthio], dihydroxyphosphoryloxy[C 1-5 )alkoxy], dihydroxyphosphoryloxy[C 1-5 )alkylthio], dihydroxyphosphoryloxy, hydroxysulfonyloxy, hydroxysulfonyl[(C 1-5 )alkoxy], hydroxysulfonyl [(C 1-5 ) alkylthio], hydroxysulfonyloxy [(C 1-5 )alkoxy], hydroxysulfonyloxy [(C 1-5 )alkylthio], [carboxy(C 1-5 )alkyl]aminocarbonyl, [dicarboxy(C 1-5 )alkyl]aminocarbonyl, [ammonio(C 1-5 )alkyl]aminocarbonyl, and {carboxy[amino(C 1-5 )alkyl}aminocarbonyl, and the other X or Z designates an accessory functional side chain spacer having the formula (II) A-(CO) r —(CH 2 ) s —W (II) wherein A designates either O, S or NH, subscript r is an integer equal to 0 or 1, subscript s is an integer ranging from 1 to 10, and W is selected from a group consisting of Formyl, acetyl, cyano, halogeno, amino, bromo- or iodo-acetamido, acylamido, diacylimido, sulfhydril, alkylthio, hydroxyl, 1,2-dihydroxyethyl, alkoxy, acyloxy, vinyl, ethynyl, free carboxyl, esterified carboxyl or in the form of a mixed anhydride, amide or hydrazide, azido, and thiocyano, provided that one of substituents X or Z designates said accessory functional side chain spacer, and the pharmaceutically acceptable salts, enantiomers and diastereomers of the N-acyl-dipeptide-like adjuvant.