Patent ID: 8747891

Claim:
A pharmaceutical composition, comprising: a antineoplastic chemotherapeutic encapsulated in ceramide anionic liposomes, wherein the liposomes comprise at least one pegylated neutral lipid, wherein the total amount of pegylated neutral lipid is an amount in the range of 5-20 Molar percent, inclusive, and wherein at least half of the amount of the pegylated neutral lipid is N-Octanoyl-Sphingosine-1-succinyl(methoxy(polyethylene)glycol)750 (PEG(750) C8); at least one anionic lipid, wherein the total amount of anionic lipid is an amount in the range of 5-15 Molar percent, inclusive; one or more ceramides selected from C4 ceramide, C6 ceramide, C8 ceramide, C10 ceramide, C12 ceramide, C14 ceramide, C16 ceramide and C18 ceramide, in an amount in the range of 1-40 Molar percent, inclusive; and cationic or neutral lipids, with the proviso that the resulting ceramide anionic liposomes have a net negative charge at physiological pH.