Patent ID: 7687623

Claim:
A compound represented by the Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are independently selected from hydrogen, (C 1 -C 6 )alkyl, halogen, cyano, trifluoromethyl, hydroxyl, (C 1 -C 6 )alkoxy, —OCF 3 , carboxy, (C 1 -C 6 alkoxy)carbonyl, —CONH 2 , —CONH[(C 1 -C 6 )alkyl], —CON[(C 1 -C 6 )alkyl] 2 , amino, (C 1 -C 6 )alkylamino or —NHCO[(C 1 -C 6 )alkyl]; R 3 is a substituent selected from hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, amino, (C 1 -C 6 )alkylamino, —C(O)(C 1 -C 6 )alkyl, or halogen; B is where Q is wherein R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are independently, selected from the group consisting of hydrogen, alkyl, alkoxy, hydroxyalkyl, alkyloxyalkyl, (C 2 -C 7 )acyloxy(C 1 -C 6 )alkyl, (C 1 -C 6 alkyl)carbonyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 8 )cycloalkyl, formyl, (C 3 -C 8 )cycloalkylcarbonyl, carboxy, (C 1 -C 6 )alkoxycarbonyl, (C 3 -C 8 cycloalkyl)oxycarbonyl, aryl(C 1 -C 6 )alkyloxycarbonyl, carbamoyl, —O—CH 2 —CH═CH 2 , (C 1 -C 6 )alkyl substituted with 1-3 halogen atoms, halogen, OCF 3 , thioalkyl, —C(O)alkyl, —C(O)aryl optionally substituted by alkyl; hydroxy, —CH(OH)alkyl, —CH(alkoxy)alkyl, nitro, —SO 2 alkyl, aminosulfonyl, (C 1 -C 6 )alkylaminosulfonyl, —SO 2 NHR 11 , —SO 2 N(R 11 ) 2 , —OC(O)N[(C 1 -C 6 )alkyl] 2 , —CONH[(C 1 -C 6 )alkyl], —CON[(C 1 -C 6 )alkyl] 2 , —(CH 2 ) p CN, (C 1 -C 6 )alkylamino, di-(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl di-(C 1 -C 6 )alkylamino, —(CH 2 ) p NR 13 R 14 , —(CH 2 ) p CONR 13 R 14 , —(CH 2 ) p COOR 12 , —CH═NOH, —CH═NO—(C 1 -C 6 )alkyl, trifluoromethylthio, R 11 and R 12 are hydrogen, C 3 -C 8 cycloalkyl, or (C 1 -C 6 )alkyl; R 13 and R 14 are hydrogen, C 3 -C 8 cycloalkyl, or (C 1 -C 6 )alkyl, or R 13 and R 14 can be taken together with the nitrogen to which they are attached to form a 4-6 membered saturated ring optionally containing O, S or N; p is 0 or 1; R is the moiety R 15 is hydrogen or (C 1 -C 6 )alkyl; Z has the formula —L—M; L has the formula wherein t is an integer from 1 to 2; R 16 is hydrogen or (C 1 -C 6 )alkyl, M is selected from the group consisting of wherein R 17 and R 18 are each, independently, an optionally substituted aryl; R 19 , R 20 , R 21 and R 22 are each, independently, (C 1 -C 6 )alkyl; R 23 is alkyl, or an optionally substituted (C 6 -C 20 )aralkyl.