Patent ID: 8053447

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R 1 is hydrogen, C 1 -C 4 alkyl, or cyclopropyl; R 2 is adamantyl optionally substituted with 0 to 1 R 18 ; R 4 is hydrogen, C 1 -C 4 alkyl, trifluoromethyl, halogen, C 1 -C 4 alkyloxy, C 1 -C 4 alkyloxyC 1 -C 4 alkyl, or C 1 -C 4 alkylcarbonyl, wherein the alkyl portion of each is substituted with 0 to 1 R 18 ; X is —O—; R 3 is -1,4-cyclohexyl-R 9 , —CH 2 -1,4-cyclohexyl-R 9 , -4-piperidin-1-yl-R 11 , or —CH 2 -4-piperidin-1-yl-R 11 ; R 9 is hydroxy, cyano, C(O)R 13 , —(CR 14 R 15 ) n C(O)NR 7 R 8 , —(CR 14 R 15 ) n NHC(O)R 16 , —(CR 14 R 15 ) n OR 16 , —(CR 14 R 15 ) n S(O) m R 16 , —(CR 14 R 15 ) n S(O) 2 NR 7 R 8 , —(CR 14 R 15 ) n NR 7 R 8 , —(CR 14 R 15 ) n NR 17 C(O)NR 7 R 8 , —(CR 14 R 15 ) n NR 17 S(O) 2 R 16 , —(CR 14 R 15 ) n C═C—R 16 , —(CR 14 R 15 ) n C≡C—R 16 , —(CR 14 R 15 ) n aryl substituted with 0 to 2 R 20 , or —(CR 14 R 15 ) n hetaryl optionally substituted with 0 to 2 R 19 ; R 11 is —C(O)NR 7 R 8 , —CH 2 C(O)NR 7 R 8 , —C(O)R 17 , —S(O) 2 R 16 or —S(O) 2 NR 7 R 8 ; R 13 is hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, cycloalkyl, C 1 -C 6 alkyloxy, aryl, aryloxy, arylC 1 -C 6 alkyloxy, hetaryl, hetaryloxy or hetarylC 1 -C 6 alkyloxy, wherein the C 1 -C 6 alkyl, cycloalkyl, aryl and hetaryl groups are optionally substituted with one or more R 19 ; R 14 and R 15 independently are hydrogen, halogen, C 1 -C 6 alkyl or cycloalkyl, wherein each is optionally substituted with 0 to 2 substituents selected independently from the group consisting of halogen, hydroxyl, and oxo; or R 14 and R 15 , together with the carbon atom to which they are attached, form a cycloalkyl ring; R 16 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, cycloalkyl, hetcycloalkyl, aryl, or hetaryl, wherein the C 1 -C 6 alkyl, cycloalkyl, aryl and hetaryl groups are each optionally substituted with one or more R 19 ; R 17 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkylC(O)R 20 , —(CR 14 R 15 ) n NR 17 S(O) 2 R 16 , cycloalkyl, hetcycloalkyl, aryl, or hetaryl, wherein the alkyl, cycloalkyl, hetcycloalkyl, aryl and hetaryl groups are each optionally are substituted with one or more R 21 ; R 18 is halogen, hydroxy, oxo, —S(O) 2 C 1 -C 4 alkyl, —S(O) 2 NR 7 R 8 or —C(O)R 13 ; R 19 is halogen, hydroxy, oxo, —C(O)R 20 , C 1 -C 6 alkylC(O)R 20 , —S(O) n R 16 , —S(O) n NR 7 R 8 , cyclopropyl, —OR 16 , C 1 -C 6 alkyl, aryl, hetaryl, —NR 22 C(O)NR 7 R 8 , —NR 22 S(O) 2 NR 7 R 8 , or —NC(O)NHS(O) 2 R 16 ; R 20 is hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, cycloalkyl, C 1 -C 6 alkyloxy, aryl, aryloxy, arylC 1 -C 6 alkyloxy, hetaryl, hetaryloxy or hetarylC 1 -C 6 alkyloxy; R 21 is halogen, cyano or hydroxy; and m and n independently are 0, 1 or 2.