Patent ID: 7022883

Claim:
A process of making a compound of the formula (A): wherein P is a nitrogen protecting group chemically suitable for Grignard reagents, Y is defined herein below; the phenyl ring in (A) is optionally benzo-fused to form naphthyl wherein substituents Y or NH—P can be independently at any position on each of the one or two rings, where the phenyl is not benzo-fused then substitution can be para, meta or ortho; said method comprising, in a one pot reaction: reacting a compound of the formula (B) with 2 equivalents of R 3 MgLi, wherein and R 3 is C 1-5 alkyl, in an aprotic solvent at a temperature between −40° C. to 40° C.: wherein X is bromine or iodine, subsequently adding an electrophile E as defined herein below, to produce a compound of the formula (A) wherein E and Y have the following corresponding relationship in the table below: E Y B(O—C 1–5 alkyl) 3 —B(OH) 2 R′HC═O —CHR′—OH R′ 2 C(═O) —CR′ 2 —OH R′X —R′ R′CO 2 R′ R′C(═O)— R′ 3 SnX SnR′ 3 R′ 3 SiX R′ 3 Si R′ 2 (OR′)SiX or SiR′ 2 (OR′) (R′ 2 SiO) 3 wherein R′ alkyl or aryl, X is halogen.