Patent ID: 8536208

Claim:
A pharmaceutical composition for oral administration which is self-emulsifying on contact with an aqueous phase which comprises: (a) an antifungally active compound of formula (I): wherein R 1 , R 2 and R 3 are independently of one another hydrogen, F or Cl; or a pharmaceutically acceptable acid addition salt thereof; and a carrier which self-emulsifies said antifungal compound on contact with the aqueous phase, wherein the carrier comprises: (b) a solubilizer component for the antifungally effective component (a) and having an HLB value of less than 20, said solubilizer component comprising: (b1) a mixture of glycerol mono-, di- and/or triesters and of polyethylene glycol mono- and/or diesters, said esters being formed with at least one fatty acid selected from the group consisting of lauric acid and oleic acid; and/or (b2) a mixture of glycerol mono-, di- and/or triesters and of polyethylene glycol mono- and/or diesters, said esters being formed with caprylic acid and capric acid, wherein the antifungally active compound of formula (I) or the pharmaceutically acceptable acid addition salt thereof is present in an amount of about 5 to 15 percent by weight based on the weight of the total composition, and wherein component (b1) is present in an amount of 50 or more than 50 percent by weight based on the total weight of the composition and in an amount of 70 or more than 70 percent by weight of the total weight of the carrier, when said pharmaceutical composition comprises the antifungally active compound of formula (I) in form of the free base, or component (b2) is present in an amount of 50 or more than 50 percent by weight based on the total weight of the composition and in an amount of 65 or more than 65 percent by weight of the total weight of the carrier, when said pharmaceutical composition comprises a pharmaceutically acceptable acid addition salt of a compound of formula (I).