Patent ID: 8658652

Claim:
A method for treating a subject suffering from an arthritis related condition, the method comprising administering to the subject a first compound according to a first dosing schedule and a second compound according to a second, different dosing schedule, wherein the first compound is methotrexate or a derivative thereof and the second compound is an antifolate compound according to Formula (6): wherein: X is CHR 8 or NR 8 ; Y 1 , Y 2 , and Y 3 independently are O or S; V 1 and V 2 independently are O, S, or NZ; Z is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or alkaryl; R 1 and R 2 independently are H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or alkaryl; R 3 is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, hydroxyl, or halo; and R 4 , R 5 , R 6 , R 7 , and R 8 independently are H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, acyl, —C(O)-alkyl, —C(O)-alkenyl, or —C(O)-alkynyl; or a pharmaceutically acceptable ester, amide, salt, solvate, enantiomer, or prodrug thereof; and wherein the first compound and the second compound are administered in amounts sufficient to provide a synergistic effect in treating the arthritis related condition.