Patent ID: 8501959

Claim:
A compound having the structure of Formula (II), or a pharmaceutically acceptable salt thereof: wherein, R 1 , R 2 , R 3 , and R 4 each are independently selected from H, halogen, —CN, —NO 2 , —OR 13 , —SR 12 , —S(═O)R 12 , —S(═O) 2 R 12 , —S(═O) 2 N(R 13 ) 2 , —NR 13 S(═O) 2 R 12 , —C(═O)R 12 , —OC(═O)R 12 , —CO 2 R 13 , —OCO 2 R 12 —, —N(R 13 ) 2 , —C(═O)N(R 13 ) 2 , —OC(═O)N(R 13 ) 2 , —NHC(═O)R 12 , —NHC(═O)OR 12 , C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 fluoroalkoxy, C 1 -C 6 alkoxy, C 1 -C 6 heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, optionally substituted phenyl, and an optionally substituted monocyclic heteroaryl; R 5 is L 5 -X 5 ; L 5 is —C 1 -C 6 alkyl-, —C 1 -C 6 fluoroalkyl-, or —C 3 -C 6 cycloalkyl-, —C 1 -C 6 alkyl- (optionally substituted aryl)-, —C 1 -C 6 alkyl- (optionally substituted heteroaryl)-, an optionally substituted aryl, or an optionally substituted heteroaryl; X 5 is F, —CO 2 R 13 , —CN, —C(═O)NHSO 2 R 12 , —C(═O)N(R 13 ) 2 , —C(═O)NH—OH, —C(═O)NH—CN, tetrazolyl, —NHS(═O) 2 R 12 , —S(═O) 2 N(R 13 ) 2 , —NR 13 S(═O) 7 R 12 , —NHC(═O)R 12 , —NHC(═O)OR 12 , —OH, —OR 13 , —SR 12 , —S(═O)R 12 , —S(═O) 2 R 12 , —N(R 13 ) 2 , —C(═O)NHC(═O)R 12 , —SO 2 NHC(═O)R 12 , —SO 2 NHC(═O)N(R 13 ) 2 , or —C(═NR 14 )N(R 13 ) 2 ; R 6 is C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 heteroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, —C 1 -C 6 alkyl- (optionally substituted cycloalkyl), —C 1 -C 6 alkyl- (optionally substituted heterocycloalkyl), —C 1 -C 6 alkyl- (optionally substituted aryl), or —C 1 -C 6 alkyl- (optionally substituted heteroaryl); R 7 is L 7 -X 7 ; L 7 is C 1 -C 6 alkyl-, C 1 -C 6 fluoroalkyl, or an optionally substituted C 3 -C 6 cycloalkyl; X 7 is —CO 7 H, —CO 7 R 12 , —C(═O)NHSO 2 R 12 , —C(═O)N(R 13 ) 2 , —C(═O)NH—OH, —C(═O)NH—CN, tetrazolyl, —NHS(═O) 2 R 12 , —S(═O) 2 N(R 13 ) 2 , —NR 13 S(═O) 7 R 12 , —NHC(═O)R 12 , —NHC(═O)OR 12 , —OH, —OR 12 , —SR 12 , —S(═O)R 12 , —S(═O) 2 R 12 , —N(R 13 ) 2 , —C(═O)NHC(═O)R 12 , —SO 2 NHC(═O)R 12 , —SO 2 NHC(═O)N(R 13 ) 2 , or —C(═NR 14 )N(R 13 ) 2 ; R 10 is H or C 1 -C 4 alkyl; R 12 is C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 fluoroalkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted benzyl or optionally substituted heteroaryl; each R 13 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 fluoroalkyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted aryl, an optionally substituted benzyl, and an optionally substituted heteroaryl; or two R 13 groups attached to the same N atom are taken together with the N atom to which they are attached to form an optionally substituted heterocycloalkyl; R 14 is selected from among H, —S(═O) 2 R 12 , —S(═O) 2 NH 2 , —C(═O)R 12 , —CN, and —NO 2 .