Patent ID: 8298783

Claim:
A process for increasing the relative abundance of a molecule having a low relative abundance in a test sample including: a) fractionating all or a portion of a test sample which includes molecules of high and low relative abundance according to a property of the molecules of the test sample, to form at least two fractions of the test sample; b) providing a population of hosts for producing a group of antibodies for binding to molecules of the test sample that have a high relative abundance in each fraction of the test sample; c) introducing each fraction of the test sample into a host of the population so that each host of the population receives one of the fractions of the test sample, to produce the group of antibodies; d) contacting the group of antibodies produced in step c) with the test sample or a test sample, wherein the antibodies deplete molecules from the test sample or a test sample to produce a first depleted sample having an increased relative abundance of a molecule having a low relative abundance in the test sample or a test sample.