Patent ID: 7045529

Claim:
A compound of formula (I) or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: A is N and B is C—R 8 , D is an aryl ring, wherein: said aryl ring is selected from the group consisting of phenyl, naphthyl, indanyl and indenyl; said aryl ring is substituted by 1-2 C 1-4 haloalkoxy groups; and, said aryl ring is substituted by 1-2 moieties selected independently from C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, halogen, C 1-4 haloalkyl, OH, C 1-4 alkoxy, (C 1-4 alkoxy)-C 1-4 alkoxy, CN, SH, C 1-4 alkylthio, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, COR 17 , CO 2 R 17 and NR 17 R 19 ; X is CH—R 9 , N—R 10 , O, S(O) n or a bond; n is equal to 0, 2 or 3; R 1 is selected from the group consisting of H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-8 cycloalkyl, C 4-12 cycloalkylalkyl or (C 1-4 alkoxy)-C 1-4 alkyl, each optionally substituted with 1 to 3 substituents selected independently from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, C 4-8 cycloalkyl, aryl, halogen, C 1-4 haloalkyl, cyano, —OR 13 , —S(O) m R 14 , —COR 13 , —CO 2 R 13 , —NR 15 COR 13 , —N(COR 13 ) 2 , NR 15 CONR 13 R 16 , —NR 15 CO 2 R 14 , —NR 13 R 16 , and —CONR 13 R 16 ; m is equal to 0, 1, or 2; R 2 is C 1-4 alkyl or C 3-8 cycloalkyl, each optionally substituted with 1-3 substituents selected from hydroxy, halo and C 1-4 alkoxy, or where X is a bond, R 2 is optionally cyano; R 3 and R 8 are each independently selected from the group consisting of H, C 1-4 alkyl, C 3-8 cycloalkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, amino, C 1-4 alkylamino, C 2-8 dialkylamino, phenyl and phenyl substituted by 1-3 groups selected from C 1-7 alkyl, C 3-8 cycloalkyl, halogen, nitro, C 1-4 alkoxy, C 1-4 alkylthio and C 2-8 dialkylamino; R 9 and R 10 are each independently H, C 1-4 alkyl or C 3-8 cycloalkyl; R 13 and R 16 are selected independently from the group consisting of at each occurrence thereof from H, C 1-4 alkyl, C 1-4 haloalkyl, C 2-8 alkoxyalkyl, C 3-6 cycloalkyl, C 4-12 cycloalkylalkyl, aryl, and (aryl)C 1-4 alkyl; R 14 is selected from the group consisting of C 1-4 alkyl, C 1-4 haloalkyl, C 2-8 alkoxyalkyl, C 3-6 cycloalkyl, C 4-12 cycloalkylalkyl, aryl, and (aryl)C 1-4 alkyl, R 15 is independently at each occurrence thereof selected from the group consisting of H, C 1-4 alkyl, C 3-7 cycloalkyl, C 4-12 cycloalkylalkyl, benzyl and benzyl substituted with 1-3 groups chosen from C 1-4 alkyl, halogen, nitro, C 1-4 alkoxy, and dimethylamino; and, R 17 , R 18 and R 19 are selected independently at each occurrence from the group consisting of H, C 1-6 alkyl, C 3-10 cycloalkyl and C 4-16 cycloalkylalkyl.