Patent ID: 8741967

Claim:
A method of treating colon cancer in a mammal, wherein the method comprises administering to the mammal a therapeutically effective amount of a compound of formula (I): wherein: R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl, —C(O)R 6 , —C(O)N(R 6 )R 7 , —S(O) t R 6 (where t is 1 or 2), —S(O) 2 N(R 6 )R 7 , —P(O) z OR 6 and —C(S)R 6 ; R 3 and R 4 are independently selected from the group consisting of hydrogen, alkyl, optionally substituted aralkyl, —C(O)R 6 , and —C(O)OR 6 , or R 3 and R 4 , together with the common nitrogen to which they are both attached, form an optionally substituted N-heterocyclyl or an optionally substituted N-heteroaryl; R 5 is selected from the group consisting of —C(R 9 )═C(R 9 )—[C(R 10 )] m —R 8 —[C(R 10 )] n —CH 3 where m+n is 6 to 10, —[C(R 10 )] 2 —C(R 9 )═C(R 9 )—[C(R 10 )] q —R 8 —[C(R 10 )] r —CH 3 where q+r is 4 to 8 and —C(R 9 )═C(R 9 )—C(R 9 )═C(R 9 )—[C(R 10 )] u —R 8 —[C(R 10 )] v —CH 3 where u+v is 4 to 8; each R 6 and R 7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocycylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, and optionally substituted heteroarylalkynyl; each R 8 is selected from the group consisting of a direct bond, an optionally substituted arylene and an optionally substituted heteroarylene; each R 9 is independently hydrogen or alkyl; each R 10 is independently selected from the group consisting of hydrogen, halo, haloalkyl, alkyl, alkenyl, alkynyl, —R 11 —OR 6 , —R 11 —OC(O)R 6 , R 11 —S(O) p R 6 (where p is 0, 1 or 2), —R 11 C(O)R 6 , —R 11 C(O)OR 6 , —R 11 —N(R 6 )R 7 , and —R 11 —C(O)N(R 6 )R 7 ; and each R 11 is independently selected from a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; where the compound of formula (I) is not as an isolated stereoisomer or mixture thereof, or a pharmaceutically acceptable salt thereof.