Patent ID: 8841462

Claim:
A compound of formula I or II: or a salt thereof, wherein: Z 1 is NR 1 or S; R 1 is H or C 1 -C 3 alkyl; R 1′ is H, C 1 -C 3 alkyl, cyclopropyl, halo, CF 3 , CHF 2 , CN, NR A R A or OR B ; each R A is independently H or C 1 -C 3 alkyl; R B is H, or C 1 -C 3 alkyl optionally substituted with one or more halo; Z 2 is CR 2 or N; Z 3 is CR 3 ; R 2 and R 3 are independently selected from H, halo, CN, CF 3 , —OCF 3 , —NO 2 , —(CR 14 R 15 ) n OR 11 or C 1 -C 12 alkyl; R 4 is H, C 1 -C 6 alkyl or C 3 -C 4 carbocyclyl; Y is W—C(O)—; W is R 5 is H or C 1 -C 12 alkyl; X 1 is —OR 11′ ; R 11′ is C 1 -C 12 alkyl, tetrahydropyran-4-yl, piperidin-4-yl, piperidiny-3-yl, pyrrolidin-3-yl, azetidinyl-3-yl, 3-hydroxy-azetidin-3-yl, pyrrolidin-2-ylmethyl, 1H-imidazol-5-ylmethyl or 1H-imidazol-2-ylmethyl; R 11 is H or C 1 -C 12 alkyl; R 14 and R 15 are H; R 6 is halo, C 2 -C 8 alkynyl, C 3 -C 5 cycloalkyl or —(CR 19 R 20 ) n SR 16 ; each R 6′ is halo or C 1 -C 6 alkyl; p is 0, 1 or 2 or 3; n is 0,1, 2 or 3; the alkyl group of R 11′ is optionally substituted with one or more (CR 19 R 20 ) n OR 16 or R 21 ; R 16 is hydrogen or C 1 -C 12 alkyl; R 19 and R 20 are H; and, R 21 is carbocyclyl.