Patent ID: 6861535

Claim:
A method for preparing pyrrolidine derivatives comprising cyclizing a compound of formula (I): wherein R 1 represents a mesyl group, a tosyl group, a nosyl group or a trityl group, R 2 and R 4 , which can be the same or different, represent a hydrogen atom, a halogen atom, a hydroxyl group, an alkyloxy group, an aryloxy group, a mesyl group, a mesylate group, a tosyl group, a nosyl group, a trityl group, an alkyl group or together represent a double bond, R 3 and R 5 , which can be the same or different, represent a hydrogen atom, a halogen atom, a hydroxyl group, an alkyloxy group, an aryloxy group, a mesyl group, a tosyl group, a nosyl group, a trityl group, an alkyl group or together represent a saturated or unsaturated C 3-9 cycloalkyl group or a C 5-10 aryl group, said cycloalkyl or aryl groups are optionally substituted by a C 1-5 alkyl group, a halogen atom, a hydroxy group, a C 1-5 alkoxy group and n is a whole number of 1, in the presence of: a) a catalyst. b) a primary amine of formula R 6 NH 3 wherein R 6 represents a hydrogen atom, an alkyl group, an aryl group or an alkylaryl group and c) a base, in a solvent to obtain pyrrolidine derivative of formula (II) below: wherein R 2 , R 3 , R 4 R 5 and n have the same meanings as in formula (I) and R 6 represents a hydrogen atom, an alkyl group, an aryl group or an alkylaryl group.