Patent ID: 6953796

Claim:
A method of inhibiting excess nitric oxide (NO) production in a mammal in need thereof to treat an illness selected from the group consisting of multiple sclerosis, cerebral, focal or global ischemia, cerebral or spinal trauma, Parkinson's disease, Huntington's disease, Alzheirner's disease, amyotrophic lateral sclerosis, migraine, depression, schizophrenia, anxiety and epilepsy, said method comprising administering to said mammal an effective inducible nitric oxide synthase (i-NOS) inhibiting amount of a compound of formula (I): wherein either Y is (CH 2 ) and X is chosen from the following group: O, NH, N—(C 1 -C 4 )alkyl, N-benzyl, N-phenyl, N-(2-pyridyl), N-(3-pyridyl), N-(4-pyridyl), N-2-pyrimidyl, N-5-pyrimidyl, S, SO, SO 2 , CH 2 and CHPh; or Y is (C═O) and X is chosen from the following group: NH, N-phenyl, N-(2-pyridyl), N-(3-pyridyl), N-(4-pyridyl), N-2-pyrimidyl and N-5-pyrimidyl; wherein the (C 1 -C 4 )alkyl contains 1 to 4 carbon atoms in a straight or branched chain; or a racemic mixture, an enantiomer, a diastereoisomer or a mixture thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof, optionally in combination with a pharmaceutically acceptable carrier.