Patent ID: 7678818

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 4 and R 5 are independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or halogen; R 3 is selected from the group consisting of: (1) C 3 -C 6 alkyl, (2) halogen-C 1 -C 6 alkyl, (3) C 3 -C 6 cycloalkyl optionally substituted by halogen or alkoxy, (4) Si(C 1 -C 6 alkyl) 3 , (5) —OR 12 , wherein R 12 is (a) C 1 -C 6 alkyl optionally substituted by halogen, hydroxy, COOC 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or phenyl which phenyl is optionally substituted by halogen or cyano, (b) halogen-C 1 -C 6 alkyl, (c) C 3 -C 6 cycloalkyl, (d) phenyl, (e) benzyl optionally substituted by halogen or cyano, or (f) S(O) 2 -C 1 -C 6 alkyl, and (6) pentafluorosulfuranyl; or R 2 and R 3 taken together with the carbon atoms they are attached to form a 5- or 6-membered carbocyclic ring or a 5- or 6-membered heterocyclic ring containing one or two heteroatoms selected from N, O or S; R 6 is hydrogen or C 1 -C 6 alkyl; R 7 and R 8 are independently hydrogen, C 1 -C 6 alkyl, hydroxy or halogen; R 9 is selected from the group consisting of: (1) hydrogen, (2) C 1 -C 6 alkyl, (3) C 2 -C 6 alkenyl, (4) halogen-C 1 -C 6 alkyl, (5) heterocyclyl, (6) heteroaryl, (7) phenyl, (8) naphthyl, and (9) —NR 14 R 15 , wherein R 14 and R 15 independently are hydrogen, C 1 -C 6 alkyl or phenyl optionally substituted by halogen; wherein said heteroaryl or phenyl is optionally substituted by: (a) halogen, (b) C 1 -C 6 alkyl optionally substituted by halogen, (c) C 1 -C 6 alkoxy optionally substituted by halogen or (d) phenyl R 10 and R 11 are independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) C 1 -C 6 alkyl optionally substituted by hydroxy, (4) —COR wherein R is C 1 -C 6 alkyl optionally substituted by halogen, C 1 -C 6 alkoxy, or C 3 -C 6 cycloalkyl, (5) —CH 2 —COO—CH 2 CH 3 , —CH 2 —COOH, or —CH 2 —CH 2 —COOH, (6) S(O) 2 —C 1 -C 6 alkyl, (7) C 3 -C 6 cycloalkyl, (8) cyano, and (9) phenyl; or together R 10 and R 11 are C 1 -C 6 alkylene; A is CR 17 or N, wherein R 17 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or C 2 -C 6 alkenyl; B is CR 18 or N, wherein R 18 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or C 2 -C 6 alkenyl; D is CR 19 or N, wherein R 19 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl or phenyl; and E is CR 20 or N, wherein R 20 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or C 2 -C 6 alkenyl; or alternatively, E is CR 20 and -A-B-D- is —N—O—, —NR 21 —N—, —S—N—, —S—CH— or —CH—S—, wherein R 21 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or C 2 -C 6 alkenyl; or E is N and -A-B-D- is —N—O—, —S—N—, —S—CH—, —CH—CH— or —CH—S—; or E is S and -A-B-D- is —CH—CH—; and n is 1, 2 or 3.