Patent ID: 8722022

Claim:
A method of dosing pharmaceutically active ingredients in a series of at least 10 compressed chewing gum tablets, the method comprising the steps of: providing one or more pharmaceutically active ingredients, mixing a chewing gum composition comprising said one or more pharmaceutically active ingredients and chewing gum granules, said chewing gum granules comprising gum base, wherein said mixing step comprises the steps of: providing an amount of said one or more pharmaceutically active ingredients in the chewing gum composition, and causing said one or more pharmaceutically active ingredients to be evenly distributed within said chewing gum composition; and dosing said chewing gum composition, whereby dosing of said pharmaceutically active ingredient in the chewing gum tablets is performed, wherein the chewing gum granules are granulated to an average particle size of below 1500 μm and subsequently further grinded to an average particle size of below 800 μm and, wherein in the step of dosing the chewing gum composition, the chewing gum composition is dosed to obtain a relative standard deviation (RSD) of dosage of pharmaceutically active ingredient of at most 6% between the series of chewing gum tablets.