Patent ID: 8647665

Claim:
A method for treating hot flushes, comprising administering to a patient in need thereof a daily dosage for a period of at least 5 weeks of 0.1 g to 1.0 g of a topical or transmucosal formulation comprising: from 0.01% to 0.5% by weight of estrogen, from 20% to 65% by weight of a C2-C4 alkanol, from 1% to 15% by weight of a polyalcohol, wherein the polyalcohol is elected from the group consisting of propylene glycol, butylene glycol, hexylene glycol and ethylene glycol; from 1% to 15% by weight of a permeation enhancer, wherein the permeation enhancer is selected from the group consisting of: diethylene glycol monoethyl ether and diethylene glycol monomethyl ether'; from 0.05% to about 4% by weight of a gelling agent, from 0.05% to 1% of a neutralizing agent; from 20% to 65% of water; wherein the amount of formulation and percentage weight of estrogen in the formulation are selected to apply a daily dosage from 0.45 mg to about 0.6 mg per day of estrogen.