Patent ID: 8518407

Claim:
An isolated antibody or antigen binding fragment thereof that specifically binds human interleukin-1 receptor type 1 (IL-1R1), comprising: (a) a heavy chain and a light chain, wherein the heavy chain comprises a heavy chain variable region comprising SEQ ID NO: 84, or the antigen binding fragment thereof, and the light chain comprises a light chain variable region comprising SEQ ID NO: 83, or the antigen binding fragment thereof, wherein the antigen binding fragment of the heavy chain variable region comprises an N-terminal or C-terminal deletion of SEQ ID NO: 84 comprising at least SEQ ID NO: 61, SEQ ID NO:64, and SEQ ID NO: 67, and the antigen binding fragment of the light chain variable region comprises an N-terminal or C-terminal deletion of SEQ ID NO: 83 comprising at least SEQ ID NO: 70, SEQ ID NO: 72, and SEQ ID NO: 74; or (b) a heavy chain and a light chain, wherein the heavy chain comprises a heavy chain variable region comprising SEQ ID NO: 82, or the antigen binding fragment thereof, and the light chain comprises a light chain variable region comprising SEQ ID NO: 83, or the antigen binding fragment thereof, wherein the antigen binding fragment of the heavy chain variable region comprises an N-terminal or C-terminal deletion of SEQ ID NO: 82 comprising at least SEQ ID NO: 62, SEQ ID NO:65, and SEQ ID NO: 68, and the antigen binding fragment of the light chain variable region comprises an N-terminal or C-terminal deletion of SEQ ID NO: 83 comprising at least SEQ ID NO: 70, SEQ ID NO: 72, and SEQ ID NO: 74.