Patent ID: 8809275

Claim:
A method of using a pharmaceutical composition to inhibit amyloid β aggregation or to slow the progression of Alzheimer's disease comprising administering the composition to a subject in need of inhibition of amyloid β aggregation, wherein the pharmaceutical composition comprises a peptoid and a pharmaceutically acceptable carrier, the peptoid having the following formula: X—(—NR a —CH 2 —CO—) b —Y wherein b is an integer between 8 and 35, wherein a is an integer between 1 and b and each consecutive a representing the R in each consecutive monomer, wherein X is H, wherein Y is selected from NH 2 , H and OH, wherein R 1 and R 6 of the peptoid are independently either an unbranched, saturated or unsaturated, C 1 -C 10 alkyl group substituted with a nitrogen and lacking a chiral center or a unbranched, unsubstituted, saturated or unsaturated C 1 -C 10 alkyl group having an (S) chiral center; wherein R 2 and R 3 are unbranched. unsubstituted C 1 -C 10 alkyl groups with an (S) chiral center or lacking a chiral center wherein at least R 4 , R 5 , R 7 and R 8 of the peptoid comprise a branched or unbranched, substituted or unsubstituted arylalkyl group with an (S) chiral center, wherein the remaining R groups are branched or unbranched, substituted or unsubstituted, saturated or unsaturated, C 1 -C 10 alky, C 4 -C 10 aryl, or C 4 -C 10 cycloalkyl groups, wherein the peptoid forms a helical structure with three monomers per such that the R groups comprising the arylalkyl groups are positioned on the same face of the peptoid, and wherein the R groups with chiral centers have an (S) chiral center.