Patent ID: 7079956

Claim:
A method of identifying a binding partner of the 30S ribosomal subunit comprising the steps of: (a) characterizing (i) an active site of the 30S ribosomal subunit from Thermus thermophilus from the atomic coordinates found in Table 1A, Table 1B, Table 1C, Table 2, Table 3, or Table 4 or (ii) an active site of a 30S ribosomal subunit by comparison to the atomic coordinates found in Table 1A, Table 1B, Table 1C, Table 2, Table 3, or Table 4, wherein said active site (i) or (ii) is bound by an antibiotic selected from the group consisting of paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin, and hygromycin B and wherein the atomic coordinates of the selected antibiotic appear in the utilized table; (b) designing or selecting a binding partner that interacts with said active site (i) or (ii) in the absence of said selected antibiotic; and (c) obtaining or synthesizing said binding partner.