Patent ID: 8088794

Claim:
A compound of formula I R—X—W—Y—R 1 I an enantiomer, a diastereomer, a pharmaceutically acceptable salt, or a N-oxide thereof wherein R is W is a substituted or unsubstituted phenyl or a substituted or unsubstituted 6-membered nitrogen-containing heteroaryl; X is O; Y is —NR a C(═O)—(CR 3 R 4 ) p —; R a is selected from H, alkyl, heterocyclyl, aryl, arylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; wherein R a is optionally substituted; R 1 is selected from R b is independently selected at each occurrence from H, optionally substituted arylalkyl, optionally substituted 5-6-membered heterocyclyl-C 1-3 alkyl, optionally substituted C 1-6 -alkyl, optionally substituted C 6-10 aryl, optionally substituted C 6-10 heteroaryl, optionally substituted 5-6 membered heterocyclyl, optionally substituted C 3-6 cycloalkyl, and R d R 5a N—C 1-3 alkyl; R c is one or more substituents selected from H, methyl, isopropyl, tert-butyl, bromo, fluoro, hydroxyl, methoxymethyl, methoxyethyl, methylthiomethyl, piperidin-1-ylmethyl, pyrrolidin-1-ylmethyl, optionally substituted phenyl, optionally substituted pyridyl, optionally substituted thienyl, R 5a R d N—, R 5a R d N—C 1-3 alkyl and optionally substituted benzyl; R d is selected from H, methyl, ethyl, isopropyl, butyl, sec-butyl, isobutyl, phenyl, and phenylmethyl; R 5a is selected from H, methyl, ethyl, isopropyl, butyl, sec-butyl, isobutyl, phenylmethyl, optionally substituted 5-6 membered heterocyclyl-C 1-2 -alkyl, optionally substituted phenyl, and optionally substituted 5-6-membered heterocyclyl; C 6-10 aryl, nitrile, —C(═O)OR 5a , —C(═O)NR 5a R d , —C(═O)R 5a and optionally substituted heteroaryl; R 3 and R 4 are each independently selected from H, alkyl, aryl, heterocyclyl, arylalkyl, heterocyclylalkyl, haloalkyl, cycloalkyl, and cycloalkylalkyl; R 5 is independently selected at each occurrence from H, alkyl, haloalkyl, heterocyclylalkyl, cycloalkylalkyl, aryl, and heterocyclyl; R 8 is one or more substituents independently selected at each occurrence from H, cyano, hydroxyl, halo, optionally substituted heterocyclyl, —C(═O)NR a R 5 , —OC(═O)NR a R 5 , —NR a C(=O)OR 5 , —NR a C(═O)—R 5 , R 5 R a N—O 2 S—, R 5 O 2 S—, R 5 O 2 SR a N—, R 5 R a N—, alkyl, aminoalkyl, alkylaminoalkyl, alkoxyalkyl, phenylalkyl, heterocyclylalkyl, alkoxy, haloalkoxy, alkylaminoalkoxy, arylalkoxy, heterocyclylalkoxy, cycloalkylalkoxy, heterocyclyl(hydroxyalkoxy), cycloalkyl(hydroxyalkoxy), aryl(hydroxyalkoxy), alkoxyalkoxy, aryloxyalkoxy, heterocyclyloxyalkoxy, cycloalkyloxyalkoxy, aryloxy, heterocyclyloxy, cycloalkyloxy; aryl and heteroaryl; p is 0, 1, 2, or 3; and wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, and alkoxy moiety of any R, R 1 , R 3 , R 4 , R 5 , R 8 and R a is optionally independently substituted with one or more groups independently selected at each occurrence from halo, oxo, —NR a R 5 , —(C 1 -C 6 )alkylamino, —NH—N═NH, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkynyl, and (C 3 -C 6 )cycloalkyl.