Patent ID: 8067584

Claim:
A compound of formula (I): wherein M 1 is —CH 2 —; M 2 is —NR 24 —; one of R 1 and R 2 is selected from hydrogen or C 1-6 alkyl and the other is selected from C 1-6 alkyl; v is 0; R 4 and R 7 are hydrogen; one of R 5 and R 6 is a group of formula (IA): and the other of R 5 and R 6 is hydrogen or methylthio; Z is —O—; R 8 is hydrogen; R 9 is hydrogen; R 10 is selected from cyclohexyl, and phenyl optionally substituted by one or more substituents R 28 ; R 11 is hydrogen; R 13 is a group of formula (IB): wherein: R 14 is hydrogen; R 15 is hydrogen; R 16 is hydroxy; R 17 is ethyl substituted on each carbon by one R 47 , wherein R 47 is hydroxyl, or R 17 is a group of formula (IC); wherein: R 18 is hydrogen; R 19 is hydrogen; R 20 is C 1-10 alkyl; wherein R 20 may be independently optionally substituted on carbon by one or more R 57 ; wherein R 57 is selected from halo or hydroxyl; p is 1; q is 0; r is 3; m is 0; n is 1; z is 0-3; R 24 is hydrogen; and each R 28 is selected from halo, hydroxy, and C 1-10 alkoxy; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof, wherein the hydrolysable ester is selected from the group consisting of: α-acyloxyalkyl ethers selected from acetoxymethoxy and 2,2-dimethylpropionyloxy-methoxy; and in vivo hydrolysable ester forming groups for hydroxy selected from alkanoyl, benzoyl, phenylacetyl, alkoxycarbonyl, dialkylcarbamoyl, N-(dialkylaminoethyl)-N-alkylcarbamoyl, dialkylaminoacetyl, and carboxyacetyl.