Patent ID: 8685932

Claim:
An isolated Transforming Growth Factor-beta-bound IgG (TIGG), comprising: an immunoglobulin (Ig) portion and a transforming growth factor-beta portion, wherein: the TGF-beta portion contains a TGF-beta protein comprising the amino acid sequence of a polypeptide that has (i) at least 95% sequence identity to SEQ ID NO: 6 and (ii) at least substantially the same binding affinity for a mammalian TGF-beta type II receptor as a polypeptide of SEQ ID NO: 6; the Ig portion contains an Ig protein with an Fc region, which has at least 95% sequence identity to the sequence of amino acids set forth in SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9 or SEQ ID NO: 10 and binds to an Fc gamma receptor; and the Ig protein and TGF-beta protein are associated via a non-covalent bond between the constant region of the Ig protein and the TGF-beta protein.