Patent ID: 8420649

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is C 1-8 -alkyl, —OC 1-8 -alkyl, —SC 1-8 -alkyl, —NHC 1-8 -alkyl, —N(C 1-8 -alkyl) 2 , C 2-8 -alkenyl, C 2-8 -alkynyl or C 3-8 -cycloalkyl, each of which is optionally substituted with 1-5 substituents of R 6 , or R 1 is a 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein said ring system is optionally substituted independently with 1-5 substituents of R 6 ; each of R 2 and R 3 , independently, is H, halo, haloalkyl, NO 2 , CN, C 1-6 -alkyl, C 1-6 -alkoxyl, C 1-6 -thioalkyl, C 1-6 -aminoalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl or C 3-6 -cycloalkyl, each of the C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl and C 3-10 -cycloalkyl optionally substituted with 1-5 substituents of R 6 ; R 4 is CN, C(O)R 6 , C 1-6 -alkyl, —OC 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl or C 3-6 -cycloalkyl, each of the C 1-6 -alkyl, —OC 1-6 -alkyl, C 2-6 -alkenyl, C 2-10 -alkynyl and C 3-6 -cycloalkyl optionally substituted with 1-5 substituents of R 6 ; R 5 is a partially or fully saturated or fully unsaturated 3-6 membered monocyclic, ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R 6 ; each R 6 , independently, is F, Cl, Br, I, CF 3 , C 2 F 5 , CN, OH, NO 2 , NH 2 , acetyl, oxo, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-6 -cycloalkyl, C 1-6 -alkylamino-, C 1-6 -dialkylamino-, C 1-6 -alkoxyl, C 1-6 -thioalkoxyl, —SO 2 C 1-6 -alkyl or a saturated or partially or fully unsaturated 5-6 membered monocyclic ring formed of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S and optionally substituted independently with 1-3 substituents of halo, haloalkyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, methylamine, dimethylamine, ethylamine, diethylamine, propylamine, isopropylamine, dipropylamine or diisopropylamine; W is O, S, NH or NCH 3 ; and X is O or S.