Patent ID: 8163903

Claim:
A process for the preparation of N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-acetamide of formula (I) comprising reacting the compound of formula (VI) with an excess of N,N-dimethylformamide dimethyl acetal (NNDMF-DMA) in a proportion of 1.5-2.5 moles of NNDMF-DMA per mole of compound (VI) under reflux, followed by addition of an apolar aromatic solvent selected from the group consisting of toluene, o-xylene, m-xylene, p-xylene, ethylbenzene, styrene and cumene, and the mixtures thereof, at a temperature ranging from 70 to 90° C., and then an apolar aliphatic solvent selected from the group consisting of n-hexane, n-heptane, n-octane, 2,5-dimethylhexane, cyclohexane, methylcyclohexane, and the mixtures thereof, at the same temperature.