Patent ID: 8754226

Claim:
A compound having the general formula I or a pharmaceutically acceptable salt or solvate thereof, wherein: L is O, NH or N(1-3C)alkyl; X 1 is N or CR 1 and X 2 is N or CR 2 , wherein only one of X 1 and X 2 may be N; R 1 , R 2 , R 3 and R 4 are independently selected from H, halogen, CF 3 , (1-6C)alkyl and (1-6C)alkoxy; R 5 is (1-3C)alkylsulfonyl, (3-6C)cycloalkylsulfonyl, (cyclopropylmethyl)sulfonyl, phenylsulfonyl, CN, Br, CF 3 , triazolyl, (1-4C)alkoxycarbonyl, R x R y NC(═O)—, oxadiazolyl optionally substituted with (1-3C)alkyl, and tetrazolyl optionally substituted with (1-3C)alkyl; or when X 1 is CR 1 and X 2 is CR 2 , then R 4 and R 5 optionally together with the atoms to which they are attached form a 5-6 membered saturated heterocyclic ring having 1-2 ring heteroatoms independently selected from O and S and optionally substituted with an oxo group, wherein the S when present is optionally oxidized; R x and R y are independently (1-4C)alkyl optionally substituted with OH, or R x and R y together with the atom to which they are attached form a 5-6 membered saturated azacyclic ring optionally substituted with OH; R 6 is H, OH or methyl; R 6a is H or methyl; R 7 is a group having the structure A 1 is N or CR a ; A 2 is N or CR b ; A 3 is N or CR c ; A 4 is N or CR d , wherein at least one of A 1 , A 2 , A 3 and A 4 is N, and no more than two of A 1 , A 2 , A 3 and A 4 may be N; R a , R b , R c and R d are independently H, CF 3 , halogen, (1-4C)alkyl or CN; R 8 is selected from hydrogen, halogen, CF 3 , CN, (1-10C)alkyl, hydroxy(1-6C)alkyl, (1-6C)alkoxy, (1-6C alkyl)sulfanyl, phenyl, pyridyl, pyrimidyl, pyrazolyl, and di(1-3C)alkylcarbamyl, wherein each of said phenyl, pyridyl, pyrimidyl, and pyrazolyl is optionally substituted with one or more substituents independently selected from halogen, (1-4C)alkyl, (1-4C)alkoxy and CF 3 ; R 9 and R 9a are independently hydrogen or methyl; and n is 1, 2 or 3.