Patent ID: 7119069

Claim:
A method for inhibiting undesired cell migration, cell invasion, cell proliferation or angiogenesis in vivo, or for inducing apoptosis in vivo, comprising administering to a subject in need thereof an effective amount of: (a) a polypeptide that is (i) a variant of native HK-D3 (SEQ ID NO: 1) designated HK-D3v, which has the amino acid sequence SEQ ID NO: 3, or (ii) a variant of native HK-D3 (SEQ ID NO: 1) that has an N-terminal addition and has the sequence SEQ ID NO: 2, wherein the polypeptide has at least 20% of the activity of native HK-D3 (SEQ ID NO: 1) in inhibiting angiogenesis, endothelial cell proliferation or endothelial tube formation in an in vitro or in vivo bioassay, or (b) an anti-angiogenic pharmaceutical composition that comprises the polypeptide of (a) and a pharmaceutically acceptable carrier, thereby inhibiting said undesired cell migration, cell invasion, cell proliferation or angiogenesis, or inducing apoptosis.