Patent ID: 7901679

Claim:
A humanized monoclonal antibody or antigen-binding portion thereof, which binds human ghrelin, wherein: each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:4 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:5; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:32 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:45; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:33 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:46; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:34 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:47; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:35 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:48; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:36 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:49; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:37 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:50; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:38 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:51; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:39 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:52; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:40 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:53; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:41 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:54; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:42 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:55; each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:43 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:56; or each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:44 and each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:57.