Patent ID: 8481518

Claim:
A method for treating urge incontinence in a subject, said method comprising: administering intravesically to the subject a pharmaceutical composition comprising: a therapeutic amount of a compound selected from the group consisting of: (1) a compound having the formula wherein Q is a group of the formula R and R 1 are each independently C 1 -C 4 -alkyl, R 1 is thienyl, phenyl, cyclopentyl or cyclohexyl and X − is a physiologically acceptable anion; (2) a compound having the formula wherein X − is a physiologically acceptable ion; (3) a compound having the formula wherein X − is a physiologically acceptable ion; (4) a compound having the formula wherein R 1 is 2-thienyl or cyclopentyl, and A is 3α-(6,7-dehydro)-tropanyl methobromide, 3β-tropanyl methobromide, or 3α-(N-isopropyl)-nortropanyl methobromide; (5) a compound having the formula wherein R is an optionally halo- or hydroxyl-substituted C 1-4 alkyl group, R 1 is a C 1-4 alkyl group, or R and R 1 together form a C 4-6 alkylene group; X − is a physiologically acceptable anion, and R 1 is H, OH, CH 2 OH, C 1-4 alkyl or C 1-4 alkoxy; (6) a compound having the formula wherein R is an optionally halo- or hydroxy-substituted C 1-4 -alkyl group, R 1 is a C 1-4 -alkyl group, or R and R 1 together form a C 4-6 -alkylene group, X − is a physiologically acceptable anion and R 1 is H, OH, CH 3 , CH 2 OH, C 1-4 -alkyl, or C 1-4 -alkoxy; (7) a compound having the formula (8) a compound having the formula and (9) a compound having the formula wherein X − is a physiologically acceptable anion and an additive which enhances adherence of said compound to the subject's bladder-wall and prolongs duration of action compared to when the compound is not in a composition containing the additive.