Patent ID: 8883772

Claim:
A compound of formula: and pharmacologically acceptable salts thereof wherein: R is an acylamine group; R 1 and R 2 , are independently selected from hydrogen, halogen, a (C1-C6) alkyl group, a (C1-C6) alkoxy group or a (C1-C6) —S-alkyl group; each of which groups is optionally substituted; Y is O—C+ or OR 3 , where R 3 is hydrogen, an alkyl group or an aryl group, each of which groups is optionally substituted, and C+ is a pharmacologically acceptable cation; and M is selected from: where W is O and R 6 and R 7 are hydrogen, halogen or optionally substituted (C1-C6) alkyl groups; or where: each R 8 is independently selected from hydrogen, halogen, or an optionally substituted (C1-C6) alkyl group; each R 10 is independently selected from hydrogen, halogen, an optionally substituted (C1-C6) alkyl group, or a —CH 2 —X group; R 12 is selected from hydrogen, an optionally substituted (C1-C6) alkyl group, or X; R 13 and R 14 are independently selected from hydrogen, an optionally substituted (C1-C6) alkyl group, or X; and X is a leaving group selected from halogen, a pyridinium, SC(O)R′, —OCOR′, —SH, —SR′, phenoxy, pentafluorophenoxy, tosyl, p-fluorotosyl, p-bromotosyl, p-nitrobenzyltosyl, or pentafluorotosyl group, where R′ is selected from optionally substituted alkyl and aryl groups; and wherein the compound contains one R 2 and one M group, and formula B is substituted with at least one —CH 2 —X group and formulas E or F are substituted with at least one —CH 2 —X or X group.