Patent ID: 7128897

Claim:
An aerosolized pharmaceutical solution, comprising: aerosolized particles of the solution, which contains an antibiotic for treating sinusitis, and a surfactant, wherein: the solution is formulated for nasal administration as an aqueous solution; the solution as formulated has an osmolality of about 300 mOsm/kg to about 880 mOsm/kg; the solution as formulated has a surface tension of about 30 to about 50 dynes/cm, wherein the surface tension is effective for retention of the solution in the nasal sinuses; the solution as formulated contains at least about 0.02% (w/v) surfactant; the antibiotic for treating sinusitis is selected from the group consisting of aminoglycosides; and wherein at least about 80% of the aerosolized particles of the pharmaceutical solution have a mass median aerodynamic diameter (MMAD) in the size range of about 0.5 μm to about 5.0 μm in diameter, whereby the aerosolized pharmaceutical solution is effective for treatment of chronic sinusitis.