Patent ID: 7371748

Claim:
A compound of formula I wherein R 1 is selected from 1,4-dioxepanyl and tetrahydropyran-4-yl; R 2 is selected from —N(R)—(CH 2 ) n -5 membered non aromatic heterocycle, —N(R)—(CH 2 ) n -5 membered non aromatic heterocycle substituted by one or two substituents selected from lower alkyl, (CH 2 ) n —OH and —NR 2 , —N(R)—(CH 2 ) n -6 membered non aromatic heterocycle, —N(R)—(CH 2 ) n -6 membered non aromatic heterocycle substituted by one or two substituents selected from lower alkyl, (CH 2 ) n —OH and —NR 2 , —(CH 2 ) n -5 membered non aromatic heterocycle, —(CH 2 ) n -5 membered non aromatic heterocycle substituted by one or two substituents selected from —(CH 2 ) n —OH, lower alkyl and lower alkoxy, —(CH 2 ) n -6 membered non aromatic heterocycle, —(CH 2 ) n -6 membered non aromatic heterocycle substituted by one or two substituents selected from —(CH 2 ) n —OH, lower alkyl and lower alkoxy —(CH 2 ) n -5 membered aromatic heterocycle, —(CH 2 ) n -5 membered aromatic heterocycle substituted by one or two substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, halogen-lower alkyl, —CH 2 N(R)(CH 2 ) 2 OCH 3 , —N(R)(CH 2 ) 2 OCH 3 , —CH 2 -morpholinyl and —CH 2 -pyrrolidinyl, —(CH 2 ) n -6 membered aromatic heterocycle, —(CH 2 ) n -6 membered aromatic heterocycle substituted by one or two substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, halogen-lower alkyl, —CH 2 N(R)(CH 2 ) 2 OCH 3 , —N(R)(CH 2 ) 2 OCH 3 , —CH 2 -morpholinyl and —(CH 2 ) n -pyrrolidinyl, (CH 2 ) n -cycloalkyl, (CH 2 ) n -cycloalkyl substituted by hydroxy, —N(R)—(CH 2 ) n -cycloalkyl, —N(R)—(CH 2 ) n -cycloalkyl substituted by a substituent selected from hydroxy and lower alkyl, —N(R)—(CH 2 ) n -phenyl, phenyl, phenyl substituted by one or two substituents selected from the group consisting of lower alkoxy, halogen, halogen-lower alkyl, lower alkyl, —CH 2 -pyrrolidin-1-yl, —CH 2 -morpholinyl, —CH 2 N(R)(CH 2 ) 2 OCH 3 and —CH 2 —N(R)C(O)-lower alkyl, 1,4-dioxa-8-aza-spiro[4,5]decane, 2-oxa-5-aza-bicyclo[2.2.1]heptane, 1-oxa-8-aza-spiro[4,5]decane, —N(R)—(CH 2 ) n -7-oxa-bicyclo[2.2.1]hept-2-yl, and 2-aza-bicyclo[2.2.2]decane; R is selected from hydrogen or lower alkyl; n is 0 or 1; or a pharmaceutically acceptable salt thereof.