Patent ID: 7884203

Claim:
An improved method for the synthesis of sucralose with an increasing yield comprising: reacting sucrose to produce sucrose-6-acetate in existence of an azo reagent as a catalyst and acetic acid as an acylating agent in a proper solvent at a temperature from 10° C. to 25° C., said azo reagent is selected from diethyl azodicarboxylate and N,N-dicyclohexylcarbodiimide (DCC); crystallizing sucrose-6-acetate from a mixed solution of DMF and acetone at a temperature from 30° C. to 50° C.; reacting the sucrose-6-acetate with a proper chlorinated reagent in the existence of trichloroacetonitrile as a catalyst, in a non-proton polar solvent at a temperature from 5° C. to 80° C. to obtain sucralose-6-acetate; crystallizing and purifying the sucralose-6-acetate from a mixed solution of alcohol and water at a temperature from 55° C. to 75° C.; alcoholyzing sucralose-6-acetate in KOH/methanol at a pH of 10-11 and a temperature from 45° C. to 50° C., thus a product of sucralose being synthesized; said acetic acid used in the synthesis of sucrose-6-acetate is from 1.4 to 1.5 times the amount of sucrose in mole, said catalyst of azo reagent is from 0.1 to 0.3 time the amount of sucrose in mole, and said solvent used in the synthesis of sucrose-6-acetate is selected from N,N-dimethylformamide (DMF) and hexamethyl phosphoramide; and a ratio of acetone and DMF used in the mixed solution in the step of crystallization and purification of sucrose-6-acetate is 2:1˜5:1.