Patent ID: 8012485

Claim:
A lyophilized composition comprising (i) a therapeutically effective amount of a conjugate comprising a humanized antibody that binds to an antigen on the surface of a cell wherein the antibody is chemically coupled to a maytansinoid that is N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine (DM1) or N2′-deacetyl-N2′-(4-mercapto-4-methyl-1-oxopentyl)-maytansine (DM4), (ii) about 0.1 mg to about 2 mg of sodium succinate per mg of the conjugate, (iii) about 0.5 mg to about 5 mg of sucrose per mg of the conjugate, and (iv) about 2 mg to about 20 mg of glycine per mg of the conjugate, wherein the composition has a pH of about 5-6 when reconstituted with water.