Patent ID: 8084427

Claim:
A monolithic implant comprising: (i) a luteinizing hormone releasing hormone analogue or a pharmaceutically acceptable salt thereof in an amount of less than 25% per weight of the total composition; and (ii) a polylactide polymer that is resistant to degradation caused by gamma-radiation and/or temperature stress, wherein the degradation-resistant polylactide polymer is a homopolymer, wherein all the repeat units of the polymer are of the formula (I); wherein the repeat units may be in the L-, D- or a mixture of the L- and D-configurations; wherein the degradation-resistant polylactide polymer has a weight-average molecular weight of 4800 to 8600 Dalton; and wherein the degradation-resistant polylactide polymer shows a degree of decomposition of less than 1000 Dalton relative to the weight-average molecular weight of the polymer after gamma-irradiation is performed with an irradiation dose of between about 25 and 40 kGy of ionizing gamma-radiation and/or wherein the degradation-resistant polylactide polymer shows a degree of decomposition of less than 1000 Dalton relative to the weight-average molecular weight of the polymer after temperature stress, at a temperature of about 30° C. over a period of at least 24 months.