Patent ID: 7524663

Claim:
A method for selecting phage displaying catalytic antibodies on the surface, comprising exposing said phage to a covalently reactive transition state analog (CRTSA) and isolating those phage that express antibodies that form a covalent link with said CRTSA; wherein said CRTSA comprises the following structural formula: R 1 —NH—CH(4-amidinophenyl)-P(═O)(O—)—O—R 2 wherein R 1 is a peptide sequence of about 5 to about 15 amino acids of an epitope of a target protein antigen for the displayed catalytic antibody, R 2 is an electron withdrawing or electron donating substituent that is a phenyl group substituted with one or more of a halogen, alkyl, aryl, NO 2 , CN, OH, O-alkyl, O-aryl C(O)O-alkyl, C(O)O-aryl or C(O)O-halo.