Patent ID: 7652022

Claim:
A compound of the formula I* wherein A is N or N→O and A′ is N or N→O, with the proviso that not more than one of A and A′ can be N→O; n is 1; m is 0; p is 0, 2 or 3; r is 0 to 5; X is NR if p is 0, wherein R is hydrogen or lower alkyl, or if p is 2 or 3, X is nitrogen which together with (CH 2 ) p and the bonds represented in dotted (interrupted) lines (including the atoms to which they are bound) forms a ring, with the proviso that the bonds represented in dotted lines, if p is zero, are absent; Y 1 is O; each of R 1 , R 2 , R 3 independently of the others, is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy, halo, halo-lower alkyl, halo-lower alkoxy, amino-lower alkyl, amino-lower alkoxy, di-lower alkyl-amino, hydroxy-lower alkyl-amino, bis-(lower alkoxy-lower alkyl)-amino, di-lower alkyl-amino-lower alkyl, phenyl, morpholinyl, piperidyl, piperidyl-lower alkyl, lower alkyl-piperazinyl, lower alkyl-piperazinyl-lower alkyl, pyridyl, or lower alkyl-imidazolyl; or any two of them together form a lower alkylene-dioxy bridge bound via the oxygen atoms, and the remaining one of these moieties is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy, halo, halo-lower alkyl, halo-lower alkoxy, amino-lower alkyl, amino-lower alkoxy, di-lower alkyl-amino, hydroxy-lower alkyl-amino, bis-(lower alkoxy-lower alkyl)-amino, di-lower alkyl-amino-lower alkyl, phenyl, morpholinyl, piperidyl, piperidyl-lower alkyl, lower alkyl-piperazinyl, lower alkyl-piperazinyl-lower alkyl, pyridyl, or lower alkyl-imidazolyl; R 5 is hydrogen, lower alkyl, or halo; and R 4 (if present, that is, if r is not zero) is lower alkyl, hydroxy, aminocarbonyl, lower alkyl-carbonyl, cyclohexyl, halo, halo-lower alkyl, lower alkoxy, amino, lower alkyl-amino, di-lower alkyl-amino, lower alkenyl-amino, lower alkyl-carbonyl-amino, cyano, azido, hydroxyl-phenyl-amino mono or tri-lower alkoxy-phenyl-amino, lower alkoxy-halo-phenyl-amino, phenyl-lower alkylamino, (mono or di-lower alkoxy)-phenyl-lower alkylamino, aminosolfonyl-phenyl-lower alkylamino, amino-lower alkoxy-phenyl-amino, lower alkyl-amino-sulfonyl-lower alkyl-phenylamino, lower alkyl-piperazinyl-lower alkylamino, morpholinyl-lower alkylamino, lower alkyl-piperidyl-amino, tetrazolyl, lower alkyl-tetrazolyl, or (di-lower alkyl)-amino-lower alkyl-tetrazolyl, or a tautomer thereof; or a pharmaceutically acceptable salt thereof.