Patent ID: 7169586

Claim:
A DNA coding for the mutant of N-acetylglutamate synthase wherein amino acid residues corresponding to positions 15 to 19 in the N-acetylglutamate synthase of SEQ ID NO: 16 are replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized wherein the N-acetylglutamate synthase is a protein defined in the following (A) or (B): (A) a protein having an amino acid sequence defined in SEQ ID NO: 16; or (B) a protein that is encoded by a DNA which hybridizes with a DNA having the nucleotide sequence defined in SEQ ID NO: 15 under stringent conditions, wherein said stringent conditions entail a temperature ranging from 60° C. to 65° C., a salt concentration ranging from 0.1×SSC to 1×SSC, and 0.1% SDS, and wherein the mutant of N-acetylglutamate synthase has a N-acetylglutamate synthase activity.