Patent ID: 8236292

Claim:
A non-liquid crystalline formulation precursor for the in vivo generation of a liquid crystalline lipid composition for the controlled release of at least one bioactive agent following parenteral administration, said formulation precursor comprising: i) a low-viscosity, non-liquid crystalline mixture having a viscosity of 1 to 1000 mPas at 20° C. and comprising: a) a minimum of 18 wt. % of a component consisting of at least one diacyl glycerol or at least one diacyl glycerol and at least one tocopherol; b) at least one phosphatidylcholine; and c) at least one biocompatible solvent comprising ethanol; ii) at least one bioactive agent dissolved or dispersed in the low viscosity mixture; wherein the formulation precursor forms at least one liquid crystalline phase structure in vivo upon contact with an aqueous fluid.