Patent ID: 8603970

Claim:
An insulin analogue of the formula I: wherein A-1 corresponds to Lys, Arg or an amino group; A0 corresponds to Lys, Arg or a chemical bond; A1 corresponds to Arg or Gly; A5 corresponds to Asp, Glu or Gln; A15 corresponds to Asp, Glu or Gin; A18 corresponds to Asp, Glu or Asn; A21 corresponds to Ala, Ser, Thr or Gly; B-1 corresponds to Asp, Glu or an amino group; B0 corresponds to Asp, Glu or a chemical bond; B1 corresponds to Asp, Glu, Phe or a chemical bond; B3 corresponds to Asp, Glu or Asn; B4 corresponds to Asp, Glu or Gln; B29 corresponds to Arg, Lys or an amino acid selected from the group comprising the amino acids Phe, Ala, Thr, Ser, Val, Leu, Glu or Asp, or a chemical bond; B30 corresponds to Thr or a chemical bond; B31 corresponds to Arg, Lys or a chemical bond; B32 corresponds to Arg-amide or Lys-amide; and wherein no more than one amino acid residue of the group comprising A5, A15, A18, B-1, B0, B1, B2, B3 and B4 correspond simultaneously and independently of one another to Asp or Glu.