Patent ID: 7563924

Claim:
A compound of formula I where R 1 is CH 2 OH, —COOR 2 , —CONHR 2 or —CONHR 3 ; R 2 is hydrogen, linear or branched C 1 -C 10 -alkyl which is optionally mono- to polyunsaturated and optionally mono- to polysubstituted by halogen, C 1 -C 4 -alkoxy, substituted C 3 -C 10 -aryl, optionally substituted C 3 -C 10 -aroyl, optionally substituted di-C 1 -C 5 -alkylamino, or tri- C 1 -C 5 -alkylamino, C 3 -C 10 -cycloalkyl which is optionally substituted by C 1 -C 4 -alkyl, C 3 -C 10 -aryl which is optionally substituted by phenyl, 1-naphthyl, 2-naphthyl which in turn is optionally substituted in position 3 and in position 4 by fluorine, chlorine, alkoxy or trifluoromethyl or in position 4 by hydroxy, halogen, phenyl, one or more C 1 -C 4 -alkyl groups, chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C 1 -C 4 -alkoxy, or C 3 -C 7 -heterocycloalkyl; R 3 is C 1 -C 15 -carboxylic acid or C 1 -C 15 -sulphonic acid; A is cis-CH═CH— or —CH 2 —CH 2 —; B is trans-CH═CH— or —CH 2 —CH 2 —; W is C 2 -C 6 -alkylene; R 4 is hydroxy, —O—R 6 or —O—R 7 R 6 is tetrahydropyranyl, tetrahydrofuranyl, trimethylsilyl, tert-butyldimethylsilyl, tert-butyldiphenylsilyl or tribenzylsilyl; R 7 is C 1 -C 15 -carboxylic acid; R 5 is hydrogen, C 1 -C 10 -alkyl or C 1 -C 10 -alkenyl; and n is the number 1-4; or a salt thereof or a cyclodextrin clathrate thereof with a physiologically tolerated base.