Patent ID: 7160909

Claim:
A tricyclic compound represented by the formula (I), or a pharmaceutically acceptable salt, or solvate thereof; wherein; R 1 is an amide, thioamide or hydrazone group represented by the formulae, wherein X is oxygen or sulfur; R a and R a′ are independently selected from hydrogen, (C 1 –C 8 )alkyl, or aryl; R a″ is hydrogen, NH 2 , (C 1 –C 8 )alkyl, aryl, (C 1 –C 8 )alkylaryl, or arylalkyl; and n is 0, 1, or 2; R 2 , and R 3 are independently selected from the group consisting of hydrogen, (C 1 –C 4 )alkyl, (C 2 –C 4 )alkenyl, —O—(C 1 –C 3 alkyl), —S—(C 1 –C 3 alkyl), (C 3 –C 4 )cycloalkyl, —CF 3 , halo, —NO 2 , —CN, or —SO 3 ; R 4 is the group (C 1 –C 20 )alkyl, (C 1 –C 20 )haloalkyl, (C 2 –C 20 )alkenyl, (C 2 –C 20 )alkynyl, (C 1 –C 10 )alkylaryl, (C 1 –C 5 )alkylcyclohexyl, (C 1 –C 5 )alkylcyclopentyl, (C 1 –C 5 )alkylcycloheptyl, phenyl, benzyl, methylnaphthyl, (C 1 –C 5 )alkylheterocyclic, carbocyclic radical, or heterocyclic radical, or aryl; R 5 , R 6 , and R 7 are independently selected from hydrogen, (C 1 –C 8 )alkyl, (C 2 –C 8 )alkenyl, (C 2 –C 8 ) alkynyl, (C 7 –C 12 )arylalkyl, (C 7 –C 12 )alkylaryl, (C 3 –C 8 )cycloalkyl, (C 3 –C 8 )cycloalkenyl, phenyl, toluyl, xylenyl, benzyl, biphenyl, (C 1 –C 8 )alkoxy, (C 2 –C 8 )alkenyloxy, (C 2 –C 8 )alkynyloxy, (C 2 –C 12 )alkoxyalkyl, (C 2 –C 12 )alkoxyalkyloxy, (C 2 –C 12 )alkylcarbonyl, (C 2 –C 12 )alkylcarbonylamino, (C 2 –C 12 )alkoxyamino, (C 2 –C 12 )alkoxyaminocarbonyl, (C 1 –C 12 )alkylamino, (C 1 –C 6 )alkylthio, (C 2 –C 12 )alkylthiocarbonyl, (C 1 –C 8 )alkylsulfinyl, (C 1 –C 8 )alkylsulfonyl, (C 2 –C 8 )haloalkoxy, (C 1 –C 8 )haloalkylsulfonyl, (C 2 –C 8 )haloalkyl, C 1 –C 8 )hydroxyalkyl, —C(O)O(C 1 –C 8 alkyl), —(CH 2 ) n —O—(C 1 –C 8 )alkyl), benzyloxy, phenoxy, phenylthio, —(CONHSO 2 R), —CHO, amino, amidino, bromo, carbamyl, carboxyl, carbalkoxy, —(CH 2 ) n —CO 2 H, chloro, cyano, cyanoguanidinyl, fluoro, guanidino, hydrazide, hydrazino, hydrazido, hydroxy, hydroxyamino, iodo, nitro, phosphono, —SO 3 H, thioacetal, thiocarbonyl, and carbonyl; where n is from 1 to 8, and R is (C 1 –C 4 )alkyl, phenyl or (C 7 –C 12 )aryl.; R8 is the group, —(La)— (acidic group) wherein —(La)—, is an acid linker having an acid linker length of 1 to 8.