Patent ID: 8357694

Claim:
A compound having the formula I: or a salt thereof, wherein: X is N, or CR c ; each R p is independently halogen, hydroxyl, unsubstituted or substituted C 1 -C 6 alkoxy, or unsubstituted or substituted C 1 -C 6 alkyl; one of R z and R z′ is H and the other is —(CH 2 ) 1 -unsubstituted or substituted C 6 -C 10 aryl, —(CH 2 ) 1 -unsubstituted or substituted C 6 -C 10 heteroaryl, or R z and R z′ , together with the carbon atom to which they are attached, form an unsubstituted or substituted 5- to 8-member heterocycle, optionally containing from 0-4 additional heteroatoms selected from N, O and S; R 1 and R 2 are each independently H, -T 1 -Q 1 , or R 1 and R 2 , together with the nitrogen atom to which they are attached, form an unsubstituted or substituted 5- to 10-member heterocycle comprising 0-4 additional heteroatoms selected from N, O and S; T 1 and T 3 are each independently unsubstituted or substituted C 1 -C 6 alkyl linker, or a bond; Q 1 is H, hydroxyl, halogen, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 1 -C 6 alkoxy, unsubstituted or substituted C 6 -C 10 aryloxy, unsubstituted or substituted amino, unsubstituted or substituted C 6 -C 10 arylamino, unsubstituted or substituted C 1 -C 6 alkylamino, unsubstituted or substituted di-C 1 -C 6 alkylamino, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, —C(O)R 7 , —C(O)OR 7 , or —C(O)NR 7 R 8 ; R 7 and R 8 are each independently -T 3 -Q 3 , or R 7 and R 8 , together with the nitrogen atom to which they are attached, form an unsubstituted or substituted 5- to 8-member heterocycle optionally containing from 0-4 additional heteroatoms selected from N, O and S; Q 3 is H, hydroxyl, halogen, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 1 -C 6 alkoxy, unsubstituted or substituted C 6 -C 10 aryloxy, unsubstituted or substituted amino, unsubstituted or substituted C 1 -C 6 alkylamino, unsubstituted or substituted di-C 1 -C 6 alkylamino, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, or unsubstituted or substituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; R c is H, cyano, halogen, or —C(O)NR 14 R 15 ; R 14 and R 15 are each independently H, or unsubstituted or substituted C 1 -C 6 alkyl; l is 0; and n is 0, 1, 2, 3 or 4.