Patent ID: 8337823

Claim:
A composition comprising a plurality of macromolecules, wherein each of the macromolecules comprises: a) a dendrimer comprising a surface layer and at least one subsurface layer; b) at least one first terminal group, each of which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and c) at least one second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein the first and second terminal groups are attached to the surface layer with a stoichiometry and topology that are not random, such that the abundance of a particular macromolecule within said plurality of macromolecules having a particular stoichiometry and topology is enriched relative to the abundance of said particular macromolecule produced in a randomly surface functionalized plurality of macromolecules, wherein stoichiometry refers to the number and type of terminal groups; and topology refers to the relationship between one terminal group and another in terms of its connection to the surface layer of the macromolecule.