Patent ID: 7754747

Claim:
A compound of Formula 1: or pharmaceutically acceptable salt or ester form thereof; wherein: Ar is phenyl, naphthyl, fluorenyl, furanyl, thienyl, benzofuranyl, benzothienyl, indolyl, pyrazolyl, or oxazolyl; R 1 is hydrogen, C 1 -C 6 alkyl, —(CH 2 ) p -phenyl or halogen; R 2 and R 3 are independently hydrogen, unsubstituted C 1 -C 6 alkyl, phenyl-(CH 2 ) p —, halogen or C 1 -C 3 perfluoroalkyl; R 4 is —CH(R 6 )(CH 2 ) n R 5 , —C(CH 3 ) 2 R 6 , —CH(R 5 )(CH 2 ) n R 6 , —CH(R 5 )C 6 H 4 R 6 , —CH(R 5 )C 6 H 3 (CO 2 H) 2 , —CH(R 5 )C 6 H 2 (CO 2 H) 3 , or an acid mimic; R 5 is hydrogen, C 1 -C 6 alkyl, C 6 -C 12 aryl, aralkyl, C 3 -C 8 cycloalkyl, or —(CH 2 ) n (R 7 ); R 6 is CO 2 H, tetrazole, or PO 3 H; R 7 is n is from 0 to 6; p is from 0 to 3; b is from 0 to 6; and a is from 0 to 6, with the proviso that when b is from 1 to 6, Ar is phenyl, furanyl, thienyl, pyrazolyl, oxazolyl, or fluorenyl.