Patent ID: 8236965

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, in racemic, enantiomeric form or any combination of these forms and in which: A is —C(O)—; Y is —NH—; R 1 and R 2 are, independently, hydrogen, (C 1 -C 8 )alkyl or (C 5 -C 9 )bicycloalkyl optionally substituted by at least one (C 1 -C 6 )alkyl or R 1 and R 2 form, together with the nitrogen atom to which they are attached, a heterocycloalkyl, a heterobicycloalkyl or the groups said group being optionally substituted by at least one: —(CH 2 ) n″ —X″—Y″, oxo, hydroxy, halo, nitro or cyano; wherein X″ is —O—, —C(O)—, —C(O)—O— or a covalent bond; Y″ is (C 1 -C 6 )alkyl, amino, (C 1 -C 6 )alkylamino, di((C 1 -C 6 )alkyl)amino, (C 3 -C 7 )cycloalkyl, heterocycloalkyl, arylalkyl, or aryl or heteroaryl optionally substituted by at least one: (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkyl-carbonyl, halo, hydroxy, nitro, cyano, CF 3 , OCF 3 , amino, (C 1 -C 6 )alkylamino or di((C 1 -C 6 )alkyl)amino; or Y″ is wherein n″ is an integer from 0 to 4; R 3 is —(CH 2 ) p —W 3 —(CH 2 ) p′ —Z 3 wherein W 3 is a covalent bond, —CH(OH)— or —C(O)—; Z 3 is (C 1 -C 6 )alkyl, adamantyl, aryl, heteroaryl, the aryl being optionally substituted by at least one —(CH 2 ) p″ —V 3 —Y 3 , halo, nitro, cyano, N 3 , or hydroxy; wherein V 3 is —O—, —S—, —C(O)—, —C(O)—O—, —SO 2 — or a covalent bond; Y 3 is (C 1 -C 6 )alkyl optionally substituted by at least one halo, amino, (C 1 -C 6 )alkylamino, di((C 1 -C 6 )alkyl)amino, phenylcarbonylmethyl, heterocycloalkyl or aryl; p, p′, and p″ represent, independently, an integer from 0 to 4; R 4 is —(CH 2 ) s —R″ 4 wherein R″ 4 is a heterocycloalkyl including at least one nitrogen atom and optionally substituted by (C 1 -C 6 )alkyl or aralkyl; a heteroaryl including at least one nitrogen atom and optionally substituted by (C 1 -C 6 )alkyl; or —NW 4 W′ 4 wherein W 4 is hydrogen, (C 1 -C 8 )alkyl or (C 3 -C 7 )cycloalkyl; W′ 4 is —(CH 2 ) s′ -Q 4 -Z 4 ; Q 4 is a covalent bond, —CH 2 —CH(OH)—[CH 2 ] t —[O] t′ —[CH 2 ] t″ — or —C(O)—O—; t, t′, and t″ are, independently, 0 or 1; Z 4 is hydrogen, (C 1 -C 8 )alkyl optionally substituted by at least one: (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkyldithio or hydroxy; (C 2 -C 6 )alkenyl; (C 2 -C 6 )alkynyl; (C 3 -C 7 )cycloalkyl optionally substituted by at least one: (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-carbonyl or (C 1 -C 6 )hydroxyalkyl; cyclohexene; adamantyl; heteroaryl; aryl optionally substituted by at least one —(CH 2 ) q″ —V 4 —Y 4 , hydroxy, halo, nitro, or cyano; wherein V 4 is —O—, —S—, —NH—C(O)— or a covalent bond; Y 4 is (C 1 -C 6 )alkyl optionally substituted by di((C 1 -C 6 )alkyl)amino or at least one halo; amino; (C 1 -C 6 )alkylamino; di((C 1 -C 6 )alkyl)amino; aralkyl; or heterocycloalkyl; q″ is an integer from 0 to 4; or Z 4 is a group of the formula s and s′ represent, independently, an integer from 0 to 6.