Patent ID: 7833532

Claim:
A lipopeptide comprising a polypeptide conjugated to one or more lipid moieties wherein: (i) said polypeptide comprises an amino acid sequence that comprises: (a) the amino acid sequence of a T helper cell (Th) epitope and the amino acid sequence of a CTL epitope, wherein said amino acid sequences are different; and (b) one or more internal lysine or lysine analogue residues for covalent attachment of each of said lipid moieties via the epsilon-amino group of said one or more lysine or lysine analogue residues; (ii) each of said one or more lipid moieties is covalently attached to an epsilon-amino group of said one or more internal lysine residues; and (iii) said lipopeptide has the general Formula (VI): wherein: epitope is a T-helper epitope or CTL epitope; A is either present or absent and consists of an amino acid spacer of about 1 to about 6 amino acids in length; n is an integer having a value of 1, 2, 3, or 4; X is a terminal side-chain group selected from the group consisting of NH, O and S; Y is either present or absent and consists of an amino acid spacer of about 1 to about 6 amino acids in length; and Z is a lipid moiety.