Patent ID: 7902218

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R is R 1 is hydrogen, C 1-6 alkyl or NHR 3 ; R 2 is C 1-6 alkyl, C 3-6 alkenyl, C 3-6 cycloalkyl or C 3-6 cycloalkyl(C 1-4 alkyl) in which each group is optionally substituted with a group selected from halogen, CF 3 , CF 2 H, OH, OCF 3 and C 1-4 alkoxy; R 3 is —C(═O)R 10 , —C(═O)OR 10 , —C(═O)NHR 10 , —S(O) n R 10 or C 1-6 alkyl optionally substituted with a group selected from C 3-6 cycloalkyl, halogen, CF 3 , OCF 3 , OH, C 1-4 alkoxy and CN; R 4 is C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 alkyl), phenyl or phenyl (C 1-4 alkyl) in which each group is optionally substituted with the group selected from halogen, C 1-4 alkyl, OH, C 1-4 alkoxy, CF 3 , CF 2 H, OCF 3 and CN; R 5 is H or C 1-6 alkyl; R 6 is H or C 1-6 alkyl, or R 5 and R 6 together form a five or six-membered carbocyclic ring which can optionally be substituted with C 1-6 alkyl or CH 2 OCH 3 ; R 7 is H, halogen, or CF 3 ; R 8 is C 1-6 alkyl, phenyl or phenyl(C 1-4 alkyl) in which each group is optionally substituted with one to two groups selected from halogen, C 1-4 alkyl, OH, CF 3 , OCF 3 and CN; X is CH or N; R 9 is OH, C 1-6 alkoxy or C 1-6 alkyl optionally substituted with halogen, OH, CF 3 , OCF 3 , or C 1-6 alkoxy; and R 10 is C 1-4 alkyl optionally substituted with the group selected from halogen, OH, CF 3 , NH 2 and C 1-4 alkoxy; or a nontoxic pharmaceutically acceptable salt thereof.