Patent ID: 7241799

Claim:
A compound of the formula: including any optical isomers, and physiologically acceptable salts thereof, wherein, Z may be in the 4-, 5-, 6- or 7-position and is selected from the group consisting of hydrogen, halogen, nitro, nitroso, amino, alkylamino, dialkylamino, azido, cyano, isothiocyano, phenyl, hydroxy, methoxy and lower alkyl; X is selected from the group consisting of halogen; hydrogen; hydroxy, lower alkanoate, formyl, amino, cyano, and isothiocyano, and if Z is not hydroxy, methoxy or lower alkyl then X may also be selected from the group consisting of OTs and azido; R 1 is selected from the group consisting of a cyclic aliphatic ring attached to the indole nitrogen with a chain having one or two carbon atoms, a bicyclic aliphatic ring attached to the indole nitrogen with a chain having one or two carbon atoms, and if Z is not hydroxy, methoxy or lower alkyl then R 1 may also be selected from a heterocyclic ring attached to the indole nitrogen with a chain having one or two carbon atoms; R 2 is selected from the group consisting of H and lower alkyl; Y is selected from the group consisting of carbonyl and CH═CH (cis or trans); and R 3 is selected from the group consisting of phenyl; napthyl; 9-anthracenyl; adamantyl; pyrenyl; phenyl with no more than two substituents selected from the group consisting of halogen, nitro, nitroso, amino, alkylamino, dialkylamino, hydroxy, methoxy, lower alkyl, azido, cyano and isothiocyano; napthyl with no more than two substituents selected from the group consisting of halogen, nitro, nitroso, amino, alkylamino, dialkylamino, hydroxy, methoxy, lower alkyl, azido, cyano and isothiocyano; and 9-anthracenyl with no more than two substituents selected from the group consisting of halogen, nitro, nitroso, amino, alkylamino, dialkylamino, hydroxy, methoxy, lower alkyl, azido, cyano and isothiocyano.