Patent ID: 7776330

Claim:
A method of treating a subject having a tumor expressing CEA, comprising administering to said subject a humanized antibody comprising: a) a variable light chain of a humanized antibody 4D5 version 8, wherein the L4, L24-L34, L50-L56, L66-L69, and L89-L97 residues of said humanized antibody 4D5 version 8 variable light chain (residues 4, 24-34, 50-56, 66-69, and 89-97, respectively of SEQ ID NO:6) have been replaced with a corresponding set of residues from the murine T84.66 monoclonal antibody variable light chain (residues 4, 24-38, 54-60, 70-73, and 93-101, respectively, or SEQ ID NO:4); and b) a variable heavy chain of a humanized antibody 4D5 version 8, wherein the H30-H35, H50-H58, and H93-H102 residues of said humanized antibody 4D5 version 8 variable heavy chain (residues 30-35, 50-58, and 93-102, respectively of SEQ ID NO:7) have been replaced with a corresponding set of residues from the murine T84.66 monoclonal antibody variable heavy chain (residues 30-35, 50-59, and 97-110, respectively, of SEQ ID NO:5); wherein said humanized antibody recognizes the same epitope as the murine monoclonal antibody T84.66.