Patent ID: 8444624

Claim:
A method for treating an isolated portion of a blood vessel, the method comprising: positioning an isolation device within the blood vessel wherein the isolation device comprises a sealing catheter and an introducer sheath, and the positioning of the isolation device comprises positioning the introducer sheath into the femoral artery in one of the legs of a patient and delivering the sealing catheter through the introducer sheath to place the first extendable element in the aorta, wherein the sealing catheter comprises a first extendable element, a first fluid exchange opening, a first fluid exchange lumen, and a first proximal connection port, wherein the introducer sheath comprises a second extendable element, a second fluid exchange opening, and a second fluid exchange lumen, wherein the extendable elements are movable relative to each other, wherein a first flow path extends from the first proximal connection port through the first fluid exchange lumen to the first fluid exchange opening of the sealing catheter, and wherein a second flow path extends from the second proximal connection port through the second fluid exchange lumen to the second fluid exchange opening of the introducer sheath; isolating the selected portion of the blood vessel by adjusting the relative positions of the extendable elements and extending the two extendable elements to contact the walls of the vessel to form the isolated portion; aspirating fluid from the isolated portion through the second flow path; and delivering a therapeutic composition to the isolated segment of the blood vessel through the first flow path after aspiration of fluid from the isolated portion of the blood vessel.