Patent ID: 7601751

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R 1 is phenyl optionally substituted with one or more groups selected from halogen, CN, CF 3 , OH, —NH 2 , —CH═CH-phenyl, pyridyl, thienyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 2-6 alkenyl, OR 21 , C 1-6 alkyl optionally substituted with OH or —NH 2 , —CH═CH—C 1-4 alkyl optionally substituted with C 1-4 alkoxy or OH, phenyl optionally substituted with halogen, —(CH 2 ) m —NHC(═O)OC 1-6 alkyl optionally substituted with R 17 , —(CH 2 ) m —NHC(═O)Ophenyl optionally substituted with halogen, —(CH 2 ) m —NHC(═O)R 18 , —NH(C═O)R 19 , —CH 2 NH(SO 2 )R 20 , —CH 2 morpholino and 4-methylpiperazinyl; R 2 and R 3 are each independently hydrogen, methyl or hydroxymethyl; m is 0 or 1; R 4 and R 5 are each independently hydrogen or methyl; R 6 is hydrogen, C 1-6 alkyl, C 1-6 alkyl NHC(═O) or CN; R 7 is hydrogen, C 1-6 alkyl, or phenylmethyl in which said phenyl is optionally substituted with one or more groups selected from halogen, CN, CF 3 , and OCH 3 ; R 8 is hydrogen, halogen, C 1-6 alkyl, C 1-4 alkoxy, CN, OH, NH 2 , benzyloxy or CF 3 ; R 17 is C 1-4 alkoxy, halogen, C 2-3 alkynyl, 4-nitrophenyl, benzyloxy or benzothiophene 1,1-dioxide; R 18 is C 1-6 alkyl or C 3-6 cycloalkyl in which each are optionally substituted with a group selected from halogen, CN, CF 3 , —N(CH 3 ) 2 , C 1-4 alkoxy, C 3-6 cycloalkyl, morpholino, thienyl, imidazolyl, pyridyl, azepinyl, benzothienyl, benzofuranyl, phenyl and methoxyphenyl; R 19 is C 1-6 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl optionally substituted with —N(CH 3 ) 2 or methylthio, phenyl, pyridyl optionally substituted with one or two halogen and C 1-4 alkyl, benzothienyl, 1-methyl-2-pyrrolyl or furanyl; R 20 is C 1-6 alkyl, 1,2-dimethyl-1H-imidazolyl, thienyl or phenyl in which said phenyl is optionally substituted with a group selected from acetyl, C 1-4 alkoxy, benzyloxy, halogen, NH(C═O)CH 3 and nitro; and R 21 is C 1-6 alkyl optionally substituted with a group selected from C 1-4 alkoxy, halogen, phenyl, furanyl and methylamino; or a nontoxic pharmaceutically acceptable salt thereof.