Patent ID: 8445721

Claim:
Process for the preparation of a compound of formula (7) wherein R 1 denotes H or C 1 -C 4 alkyl, Spacer denotes a C 1 -C 4 alkylene group optionally interrupted by an oxygen atom, R 2 denotes a bio-molecule residue having at least one free amino function, and X denotes a physiological acceptable anion, comprising the steps of: a) reacting a compound of formula (5): wherein R 1 denotes H or C 1 -C 4 alkyl, Spacer denotes a C 1 -C 4 alkylene group optionally interrupted by an oxygen atom, or R 1 and Spacer together with the adjacent nitrogen atom forms a 4-azonia-spiro[3.5]nonyl group, and X denotes a physiological acceptable anion, with [ 18 F]-fluoride to form a compound of formula (6): wherein R 1 denotes H or C 1 -C 4 alkyl, Spacer denotes a C 1 -C 4 alkylene group optionally interrupted by an oxygen atom, and X denotes a physiological acceptable anion; and b) reacting said compound of formula (6) with a peptide of the formula (8): R 2 NH 2 (8) wherein R 2 denotes a bio-molecule residue having at least one free amino function, to obtain said compound of formula (7).