Patent ID: 8518950

Claim:
A compound represented by structural formula (V): or a pharmaceutically acceptable salt thereof, wherein: each Z is independently selected from the group consisting of a lower alkyl, a lower haloalkyl, a halo, a lower alkoxy, a lower alkyl sufanyl, cyano, nitro, or lower haloalkoxy; R 12 is an aryl or a heteroaryl, wherein the aryl and heteroaryl are optionally substituted with one or more substituent selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, a halo, cyano, nitro, —OR 17 , —SR 17 , —S(O) p R 17 , —S(O) p OR 17 , —OS(O) p R 17 , —OS(O) p OR 17 , —NR 17 S(O) p R 17 , —S(O) p NR 15 R 16 , —NR 15 R 16 , —C(X 3 )R 17 , —C(X 3 )OR 17 , —C(X 3 )SR 17 , —C(X 3 )NR 15 R 16 , —NR 17 C(X 3 )R 18 , —NR 17 C(X 3 )OR 18 , —NR 17 C(X 3 )SR 18 , —NR 17 C(X 3 )NR 15 R 16 , —OC(X 3 )R 17 , —OC(X 3 )OR 17 , —OC(X 3 )SR 17 , —SC(X 3 )OR 17 , —SC(X 3 )SR 17 , —OC(X 3 )NR 15 R 16 , —SC(X 3 )NR 15 R 16 , —P(X 4 )(X 5 R 17 ) 2 , —X 5 P(X 4 )(X 5 R 17 ) 2 , —P(X 4 )(R 17 ) 2 , —P(X 4 )(R 17 )(X 5 R 17 ); R 13 is a cycloalkyl, a cycloalkenyl, an aryl, or a heteroaryl, wherein the cycloalkyl, cycloalkenyl, aryl, or heteroaryl are optionally substituted with one or more substituents selected from the group consisting of a lower alkyl, a halo, cyano, nitro, a lower haloalkyl, a lower alkoxy, a lower sulfanylalkyl, —S(O) p R 31 , —S(O) p NR 29 R 30 , —NR 29 R 30 , —C(O)R 28 , —C(O)OR 28 , —C(O)NR 29 R 30 , —NR 29 C(O)R 30 , —NR 29 C(O)OR 28 , —NR 28 C(O)NR 29 R 30 , —OC(O)R 28 , —OC(O)OR 28 , and —OC(O)NR 29 R 30 ; wherein R 28 , R 29 , R 30 , for each occurrence are, independently, H or a lower alkyl; and R 31 , for each occurrence, is independently a lower alkyl; R 14 , for each occurrence is independently selected from —H, an alkyl, —C(O)R 20 , or —C(O)OR 20 ; R 15 and R 16 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; or R 15 and R 16 taken together with the nitrogen to which they are attached are heterocyclyl or heteroaryl; R 17 and R 18 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; R 19 , for each occurrence, is independently —H, a halo, an alkyl, —OR 17 , —NR 15 R 16 , —C(O)R 17 , —C(O)OR 17 , or —C(O)NR 15 R 16 ; R 20 , for each occurrence, is independently, H or an alkyl; X 3 is ═O, ═S, or ═N—R 19 ; X 4 is ═O or ═S; X 5 is —O— or —S—; n is 0, 1 or 2; and p is 1 or 2.