Patent ID: 7078210

Claim:
A DSP-3 substrate trapping mutant polypeptide comprising an amino acid sequence that differs from the amino acid sequence set forth in SEQ ID NO:2 by a substitution at position 57 or position 88 of SEQ ID NO:2, such that the DSP-3 substrate trapping mutant polypeptide binds to a substrate with an affinity that is not substantially diminished relative to the affinity with which a DSP-3 polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2 binds to the substrate, and such that an ability of the DSP-3 substrate trapping mutant polypeptide to dephosphorylate a substrate is reduced relative to the ability of the DSP-3 polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2 to dephosphorylate the substrate.