Patent ID: 8048901

Claim:
A compound of the formula I wherein ring A is cyclohexandiyl; R1, R2 are each independently H, F, Br, Cl, SF 5 , S—(C 1 -C 6 )-alkyl, CF 3 , OCF 3 , (C 1 -C 6 )-alkyl, O—(C 1 -C 6 )-alkyl, SCF 3 , phenoxy, OCF 2 CHF 2 , OCF 2 CF 3 , (C 1 -C 6 )-alkyl-(C 1 -C 6 )-alkoxy, O(C 1 -C 6 )-alkyl-(C 1 -C 6 )-alkoxy or benzyloxy; R3 is H, CF 3 , (C 1 -C 6 )-alkyl, (C 3 -C 8 )-cycloalkyl or phenyl; X is (C 1 -C 6 )-alkanediyl, wherein one or more carbon atoms therein are optionally replaced by oxygen atoms; Y is S, O or a bond; m is 1, 2 or 3; n is 0 or 1; Z is O, S, CO or CO—NH; R is H, OH, CH 2 —CO—NH—OH, CH 2 —CO—NH—(C 1 -C 6 )-alkyl, CH 2 —CO—NH—(C 1 -C 6 )-alkoxy, NR4R5 or a 5-, 6-, 7-, 8-, 9-, 10-, 11- or 12-membered mono or bicyclic ring that is unsaturated, partially unsaturated or saturated, and optionally contains one to four heteroatoms selected from the group consisting of N, O and S, and wherein said 5-, 6-, 7-, 8-, 9-, 10-, 11- or 12-membered mono or bicyclic ring is optionally benzo-fused, and optionally substituted by F, Cl, Br, CN, SH, COOH, (C 1 C 4 )-alkyl, (C 1 -C 6 )-alkoxy, SO 2 —(C 1 -C 4 )-alkyl, NO 2 , CF 3 , OCF 3 , (C 1 -C 6 )-alkyl-(C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy-phenyl, phenoxy, NHSO 2 CF 3 or B(OH) 2 ; R4 is H or (C 1 -C 6 )-alkyl; R5 is OH, NH 2 , SO 2 —CF 3 , SO 2 -phenyl-CF 3 , CO—CF 3 , (C 1 -C 6 )-alkoxy or phenyl optionally substituted by CH 3 or COOH; or R4 and R5, taken together with the nitrogen atom to which they are attached, form a 5-membered aromatic heterocycle which is optionally fused to an aromatic 5-, 6-, or 7-membered ring, said aromatic 5-, 6-, or 7-membered ring optionally having one, two, three or four nitrogen atoms, and optionally substituted by F, Cl, Br, CF 3 , OCF 3 , COOH, SO 2 CH 3 , CN, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkyl, (C 1 -C 6 )-alkyl-phenyl, (C 1 -C 6 )-alkyl-(C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy-phenyl or phenoxy; and pharmaceutically acceptable salts thereof.