Patent ID: 8168584

Claim:
A method of treating age-related macular degeneration (ARMD), comprising the step of: administering a composition comprising an effective amount of a compstatin analog to a subject suffering from ARMD, wherein the compstatin analog is a compound that comprises a cyclic peptide comprising a cyclic portion 11 amino acids in length having a core sequence of X′aa-Gln-Asp-Xaa-Gly-X″aa (SEQ ID NO: 4), where X′aa and Xaa are each independently selected from Trp and analogs of Trp and X″aa is selected from Ala, single methyl unbranched amino acids, Phe, Trp, and analogs of Trp, and wherein, when the core sequence is aligned with the sequence of compstatin (i) X′aa corresponds to position 4 of compstatin; (ii) X″aa corresponds to position 9 of compstatin; and (iii) the peptide is cyclized via a bond between amino acids at positions that correspond to position 2 and position 12 of compstatin.