Patent ID: 7884108

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof or mixture thereof, wherein X is chosen from N and CR 2 ; Y is chosen from N and CR 3′ ; Z is chosen from N and CR 3 ; provided that only one of X, Y and Z is N at a time; W is N; V is CH; R 1 is chosen from: R 2 is chosen from H, CH 3 , F, Cl, CN, OCH 3 , OH and CF 3 ; R 2′ is chosen from H and F; R 3 is chosen from H, CH 3 , CF 3 , F, Cl, CN and OCH 3 ; R 3′ is chosen from H, CH 3 , F, Cl, CN and OCH 3 ; R 4 is m is chosen from 0 and 1; n is chosen from 0 and 1; R 5 is chosen from H, C 1 -C 6 alkyl, and C 3 -C 6 cycloalkyl, wherein said alkyl is optionally substituted with one or more substituents chosen from OH, F, and OCH 3 ; R 6 is chosen from H and C 1 -C 6 alkyl; or R 5 and R 6 are optionally taken together with the nitrogen atom to which they are attached to form a 4- to 6-membered cyclic ring having 0-1 additional N, S or O, wherein the optional additional ring nitrogen is optionally substituted with C 1 -C 3 alkyl and said cyclic ring is optionally substituted with OH; R 7 is chosen from H, C 1 -C 6 alkyl, and C 3 -C 6 cycloalkyl, wherein said alkyl is optionally substituted with one or more substituents chosen from OH and O(C 1 -C 4 alkyl); or R 6 and R 7 are optionally taken together with the —N(R 5 )C(R 9 )(CH 2 ) n C(═O)N(R 8 )— group through the respective nitrogen atoms to which they are directly attached to form a 6-membered cyclic ring; R 8 is chosen from H and C 1 -C 6 alkyl, wherein said alkyl is optionally substituted with one or more substituents chosen from OH, F, and OCH 3 ; or R 7 and R 8 are optionally taken together with the nitrogen atom to which they are attached to form a 4- to 6-membered cyclic ring having 0-1 additional N, S or O, wherein the optional additional ring nitrogen is optionally substituted with C 1 -C 3 alkyl and said cyclic ring is optionally substituted with OH; R 9 is chosen from H and CH 3 ; R 10 is chosen from OH, H and C 1 -C 3 alkyl optionally substituted with N(R 9 ) 2 ; R 11 is chosen from H, CH 3 and CF 3 ; and R 12 is C 1 -C 3 alkyl.