Patent ID: 7241883

Claim:
A conjugate composition comprising one or more, in any combination, of Structures 1–6: wherein: n is 0, 1, 2, or 3; X and Y are oxygen and/or sulfur in any combination; X 2 and X 3 are chlorine or fluorine; Y 2 is nitrogen or carbon; arom is a substituted or unsubstituted phenyl, naphthyl or other polycyclic aromatic ring structure; Z is chloride, fluoride, 2,3,5,6-tetrafluoro-4-sulfo-phenoxide, N-hydroxysuccinimide or other electrophilic group; and R 1 –R 6 comprise hydrocarbon linker groups containing from 2–1000 atoms, optionally containing one or more halogen or heteroatoms selected from the group consisting of O, N, Si, P and S; wherein said one or more, in any combination, of Structures 1–6 are connected through their respective linker groups, R 1 –R 6, to at least one entity B, wherein B is a polymeric microsphere or a polymeric nanosphere, and wherein the polymeric sphere comprises polystyrene/divinyl benzene and carboxyl functional groups at least on its surface.