Patent ID: 6977263

Claim:
A compound of formula (I): such that Ar is an aryl or a heteroaryl, and the group is beta to the on the aryl, wherein, is a single or a double bond; R 1 and R 2 are each independently hydrogen or lower alkyl; R 3 is aryl, arylalkenyl, cycloalkenyl, cycloalkyl, heteroaryl, heteroarylalkenyl, heterocycloalkenyl, a carbon linked heterocycloalkyl or alkyl optionally substituted by one or more groups selected from hydroxy, alkoxy, alkyloxycarbonylamino, cycloalkyl, heterocycloalkyl, R 6 , —OR 6 , —S(O) m R 6 or —C(═O)—R 6 ; R 4 is hydrogen, acyl, alkoxy, alkyloxycarbonyl, carboxy, cyano, halo, hydroxy, —C(═O)—NY 1 Y 2 or alkyl optionally substituted with alkoxy, alkylcarbonylamino, alkylsulfonylamino, hydroxy, —S(O) m -alkyl or —NY 1 Y 2 ; R 6 is aryl or heteroaryl; Y 1 and Y 2 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl; or the group —NY 1 Y 2 may form a cyclic amine; m is zero or an integer 1 to 2; and n is 2; or an N-oxide of said compound, a prodrug of said compound, a pharmaceutically acceptable salt of said compound, a solvate of said compound or a hydrate of said compound.