Patent ID: 8729274

Claim:
A tricyclic heterocyclic derivative according to Formula I wherein m is 1 and n is 0; R 1 is H; R 2 is H, C 3-5 cycloalkyl or C 3-5 cycloalkylC 1-2 alkyl said C 1-4 alkyl, C 3-5 cycloalkyl and C 3-5 cycloalkylC 1-2 alkyl each being optionally substituted with one or more halogens; R 3 is C 1-4 alkyl, hydroxyC 1-2 alkyl or C 1-2 alkyloxyC 1-2 alkyl said C 1-4 alkyl and C 1-2 alkyloxyC 1-2 alkyl each being optionally substituted with one or more halogens; L 1 is C═O or CR 4 R 5 ; L 2 is CR 4′ R 5′ ; R 4 , R 4′ , R 5 and R 5′ are each independently H, F, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, hydroxy, C 1-4 alkyloxy, C 1-2 alkyloxyC 1-2 alkyl, C 3-5 cycloalkyl or C 3-5 cycloalkylC 1-2 alkyl said C 1-4 alkyl, C 3-5 cycloalkyl and C 3-5 cycloalkylC 1-2 alkyl each being optionally substituted with one or more halogens or one of R 4 and R 4′ together with one of R 5 and R 5′ along with the atoms to which they are bonded form a 3-6 membered ring optionally comprising a heteroatom selected from O, S and NR 4 ″, wherein R 4 ″ is H, C 1-4 alkyl, COC 1-4 alkyl or SO 2 C 1-4 alkyl; Y 1 is N or CR 6 ; Y 2 is N or CR 7 ; Y 3 is N or CR 8 ; Y 4 is N or CR 9 with the proviso that no more than two of Y 1 -Y 4 can be N simultaneously; R 6 is H, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, or halogen, said C 1-6 alkyl, and C 2-6 alkenyl being optionally substituted with one or more halogens; R 7 is H, C 1-6 alkyl, C 3-7 cycloalkyl, C 6-10 arylC 1-2 alkyloxy or halogen, said C 1-6 alkyl, and C 6-10 arylC 1-2 alkyloxy being optionally substituted with one or more halogens; R 8 is H, C 1-6 alkyl, C 3-7 cycloalkyl, C 6-10 arylC 1-2 alkyloxy or halogen, said C 1-6 alkyl, and C 6-10 arylC 1-2 alkyloxy being optionally substituted with one or more halogens; R 9 is H, with the proviso that R 6 -R 9 cannot simultaneously be H; R 10 and R 11 are each independently H or C 1-6 alkyl; and R 12 is C 1-6 alkyl; or a pharmaceutically acceptable salt thereof.