Patent ID: 8461166

Claim:
A radiolabeled compound having the general Formula I*: and comprising a radiolabeled polyalkylene glycol or a non-radiolabeled polyalkylene glycol moiety being covalently attached at position 7 of the compound having said Formula I, wherein: Q1 is X—W(═Y)—Z and Q2 is absent, X is —NR 1 ; W is selected from the group consisting of a non-radioactive carbon and a radioactive carbon; Y is selected from the group consisting of oxygen and sulfur; Z is selected from the group consisting of —R 2 C═CHR 3 and —CR 4 R 5 R 6 ; R a is selected from the group consisting of hydrogen or alkyl having 1-8 carbon atoms; A, B, C and D are each independently selected from the group consisting of hydrogen, a first non-radioactive derivatizing group and a first radioactive derivatizing group selected from a radioactive bromine, a radioactive iodine and a radioactive fluorine; R 1 is selected from the group consisting of hydrogen, and substituted or nonsubstituted alkyl having 1-6 carbon atoms; R 2 is selected from the group consisting of hydrogen, halogen and alkyl having 1-6 carbon atoms; R 3 is selected from the group consisting of hydrogen, halogen, carboxy, alkenyl, alkoxy, carbonyl, substituted or non-substituted alkyl having 1-6 carbon atoms, substituted or non-substituted phenyl and substituted or non-substituted alkyl having 1-6 carbon atoms at least one being a radioactive carbon; R 4 is a leaving group; and R 5 and R 6 are each independently selected from the group consisting of hydrogen and a second derivatizing group, and wherein said polyalkylene glycol moiety has a general Formula II*: —[U(CR′R″)m]nV Formula II* wherein: m is an integer from 1 to 6; n is an integer from 2 to 10; U is O, S or NR′″; V is selected from the group consisting of a radioactive third derivatizing group and a non-radioactive third derivatizing group selected from the group consisting of a radioactive atom, hydroxyl, thiol, amine, alkyl, cycloalkyl, halogen, haloalkyl, alkoxy, thioalkoxy, thiophenyl, alkenyl, alkynyl, amide, carboxylate, thiocarboxylate, sulfinyl, sulfonyl, carbamyl, thiocarbamyl, nitro and cyano; and R′, R″ and R′″ are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl, the compound comprising at least one radioactive atom.