Patent ID: 8497278

Claim:
A compound having the structure: wherein: R 1 , R 2 , R 3 and R 4 are each members independently selected from H, D, halogen, hydroxyl, dialkylamino, cyano, sulfonamide, acyl, substituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; wherein substituents on said substituted alkyl, substituted alkoxy, substituted heterocycloalkyl, substituted aryl and substituted heteroaryl are chosen from —OR′, ═O, ═NR′, —NR′R″, —SR′, -halogen, —OC(O)R′, —C(O)R′, —CO 2 R′—NR″C(O)R′, —NR′—C(O)NR″R′″, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR′R″, —NRSO 2 R′, —CN and —NO 2 ; wherein R, R′, R″ and R′″ are chosen independently from H, alkyl and aryl; and substituents on said substituted aryl and substituted heteroaryl may additionally be alkyl; Y is a member selected from a single bond, NH, ND, S, and O; and A 3 is selected from: or a pharmaceutically acceptable salt thereof.