Patent ID: 7354576

Claim:
A method of treating diseases caused all or in part by a deficiency in Î±-L-iduronidase, the method comprising administering a pharmaceutical composition comprising a human recombinant Î±-L-iduronidase of SEQ ID NO:2, or a biologically active fragment thereof which possesses the same or similar biological activity to SEQ ID NO:2, a pharmaceutically acceptable carrier, and a polysorbate, wherein said recombinant Î±-L-iduronidase of SEQ ID NO:2 or biologically active fragment thereof has a purity of greater than 99%, to a human subject in need thereof in an amount effective to alleviate symptoms of said deficiency, wherein said treatment reduces lysosomal storage of glycosaminoglycans (GAGs) in the tissue of said human subject caused all or in part by said deficiency.