Patent ID: 7459169

Claim:
A medical device comprising: a structure adapted for introduction into a patient, wherein the structure comprises a surface; a layer of coating adsorbed on the surface of the medical device; wherein the coating comprises a block copolymer further comprising at least one regulator of complement activation bound through an end group of the block copolymer; and wherein the regulator of complement activation is selected from the group consisting of factor H, factor H like protein 1 (FHL-1), factor H related proteins, C4 binding protein (C4bp), complement receptor 1 (CR1), compstatin, decay-accelerating factor (DAF), membrane cofactor protein (MCP), vaccinia virus complement control protein (VCP), small pox inhibitor of complement enzymes (SPICE), and fragments thereof such that the surface of the medical device is deactivating to the complement cascade as compared to a non-coated surface of the medical device.