Patent ID: 7407958

Claim:
A compound of formula (I): wherein: R1 is wherein X1 is N; R2 is H, OH, —O—C1-6 alkyl, —S—C1-6 alkyl, C1-6 alkyl, phenyl, C1-6 haloalkyl, NH 2 , NH(CH 2 )n-Ph, NH—C 1-6 alkyl, halo, CN, NO 2 , CONHR or SO 2 NHR, wherein R is H or C1-6 alkyl, and n is 0, 1, 2, or 3; R3 is H, C1-6 alkyl, C3-7 cycloalkyl, —(CH 2 )p-NO 2 , —(CH 2 )p-NR 4 R 5 , —(CH 2 )p-CHO, —(CH 2 )p-CONHOH, —(CH 2 )p-CN, —(CH 2 )p-CO 2 H, —(CH 2 )p-CO 2 R 4 , —(CH 2 )p-CONR 4 R 5 , —(CH 2 )p-tetrazole, —(CH 2 )p-COR 4 , —(CH 2 )q-(COR 6 ) 2 , —(CH 2 )p-OR 4 , (CH 2 )p-CH═CH—CN, —(CH 2 )p-CH═CH—CO 2 H, —(CH 2 )p-CH═CHCO 2 R 4 , —(CH 2 )pCH═CH—CONR 4 R 5 , —(CH 2 )p-NHCOR 4 , —(CH 2 )p-NHCO 2 R 4 , —(CH 2 )p-CONHSO 2 R 4 , (CH 2 )p-NHSO 2 R 4 or —(CH 2 )p-CH═CH-tetrazole; R 4 and R 5 are independently H or C1-6 alkyl; R 6 is C1-6 alkyl; p is 0, 1, 2, 3, or 4; q is 1, 2, 3, or 4; X is C1-10 alkylene, C2-10 alkenylene or C2-10 alkynylene; one of A1 and A2 is N and the other is NR 7 ; and R 7 is H, OH, C1-6 alkyl, or C3-7 cycloalkyl; or a pharmaceutically-acceptable salt or hydrate thereof.