Patent ID: 7192978

Claim:
A compound of formula (I): wherein B represents a group chosen from phenyl, naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl, benzo[1,3]dioxolyl, biphenyl, and a 5 to 10-membered heteroaromatic group containing one or more heteroatoms chosen from N, O and S; R 1 , R 2 and R 3 each independently represent a group chosen from a hydrogen atom, a halogen atom, hydroxy, phenyl, —OR 5 , —SR 5 , —NR 5 R 6 , —NHCOR 5 , —CONR 5 R 6 , —CN, —NO 2 , —COOR 5 , —CF 3 , a straight optionally substituted lower alkyl group, and a branched optionally substituted lower alkyl group; or R 1 and R 2 together form an aromatic or alicyclic ring or a heterocyclic group; R 5 and R 6 each independently represent a group chosen from a hydrogen atom, a straight optionally substituted lower alkyl group and a branched optionally substituted lower alkyl group, or R 5 and R 6 together form an alicyclic ring; n is an integer from 0 to 4; A represents a group chosen from O—, —S—, —S(O)—, and —S(O) 2 —; m is an integer from 0 to 8; R 4 represents a lower alkyl group; D represents a group of formula i) wherein R 9 represents a group chosen from phenyl, 2-furyl, 3-furyl, 2-thienyl and 3-thienyl; R 10 represents a group chosen from phenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl and C 3 –C 7 cycloalkyl; and R 11 represents a group chosen from a hydrogen atom, hydroxy, methyl, or - and CH 2 OH; wherein each of the cyclic groups represented by R 9 and R 10 is independently optionally substituted by one or two substituents chosen from halogen, straight optionally substituted lower alkyl, branched optionally substituted lower alkyl, hydroxy, optionally substituted lower alkoxy, nitro, cyano, —CO 2 R 12 and —NR 12 R 13 , wherein R 12 and R 13 are identical or different and are each independently chosen from a hydrogen atom, straight optionally substituted lower alkyl groups and branched optionally substituted lower alkyl groups; and X − represents a pharmaceutically acceptable anion of a mono or polyvalent acid; or an individual stereoisomers of a compound of formula (I) or mixture of stereoisomers of a compound of formula (I); with the proviso that in those compounds of formula (I) wherein B is phenyl, R 9 is unsubstituted phenyl, R 10 is unsubstituted phenyl or unsubstituted C 3 –C 7 cycloalkyl, and R 11 is hydrogen or hydroxy, the sequence —(CH 2 ) n —A—(CH 2 ) m — is not one of methylene, ethylene or propylene.