Patent ID: 7851484

Claim:
At least one chemical entity chosen from compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen; R 2 is selected from hydrogen, halo, hydroxy, optionally substituted acyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted alkoxy, aminocarbonyl, sulfonyl, sulfanyl, sulfinyl, carboxy, optionally substituted alkoxycarbonyl, and cyano; R 3 is selected from hydrogen, halo, hydroxy, optionally substituted acyl, substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted O-alkyl oxime, optionally substituted heterocycloalkyl; optionally substituted cycloalkyl, optionally substituted alkoxy, aminocarbonyl, sulfonyl, sulfanyl, sulfinyl, carboxy, optionally substituted alkoxycarbonyl, and cyano; and R 4 is alkyl optionally substituted with one or more groups chosen from hydroxyl, optionally substituted alkoxy, optionally substituted amino and optionally substituted heterocycloalkyl; provided that at least one of R 2 and R 3 is not hydrogen; and further provided that the compound of Formula I is not 6-bromo-1-methyl-1H-imidazo[4,5-b]pyridin-2-ol; or 6-iodo-1-methyl-1H-imidazo[4,5-b]pyridin-2-ol.