Patent ID: 7531526

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof; wherein: P is hydrogen or an amino-group-protecting moiety; B 1 , at each occurrence, is CH; X 1 , at each occurrence, is —C(O)—NH—; X 2 is —C(O)—NH—; R is hydrogen or alkyl, or R forms together with the adjacent R 1 , or when A is zero, forms together with the adjacent R 2 , a nitrogen-containing mono-, bi- or tri-cyclic, saturated or partially saturated ring system having 4-14 ring members, and one or two optional substituents selected from the group consisting of keto, hydroxy, aryl, alkoxy and aryloxy; R 1 , at each occurrence, and R 2 and R 3 are each independently one of hydrogen, alkyl, cycloalkyl, aryl, a 5-10 membered saturated, partially unsaturated or aromatic heterocycle or —CH 2 —R 5 , where the ring portion of any of said aryl or heterocycle can be optionally substituted; R 5 , in each instance, is one of aryl, aralkyl, alkaryl, cycloalkyl, a 5-10 membered saturated, partially unsaturated or aromatic heterocycle or —W—R 6 , where W is a chalcogen and R 6 is alkyl, where the ring portion of any of said aryl, aralkyl, alkaryl, or heterocycle can be optionally substituted; provided that at least one of R 1 , R 2 , or R 3 is where R 9 is one of alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroarylalkyl; wherein the alkyl is optionally substituted with one of C 1-6 alkyl, halogen, monohalo(C 1-6 )alkyl, and trifluoromethyl; and wherein said cycloalkyl, aryl, aralkyl, heteroaryl and heteroarylalkyl groups are optionally substituted with one or two of C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyl(C 3-8 )cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, cyano, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, benzylamino, dibenzylamino, nitro, carboxy, carbo(C 1-6 )alkoxy, trifluoromethyl, halogen, C 1-6 alkoxy, C 6-10 aryl, C 6-10 aryl(C 1-6 )alkyl, C 6-10 aryl(C 1-6 )alkoxy, hydroxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 6-10 arylthio, C 6-10 arylsulfinyl, C 6-10 arylsulfonyl, C 6-10 aryl, C 1-6 alkyl(C 6-10 )aryl, and halo(C 6-10 )aryl; A 1 and A 2 are independently one of hydrogen, halogen, C 1-6 alkyl, monohalo(C 1-6 )alkyl, or trifluoromethyl; Z 1 and Z 2 are independently one of alkyl, hydroxy, alkoxy, or aryloxy, or together Z 1 and Z 2 form a moiety derived from a dihydroxy compound having at least two hydroxy groups separated by at least two connecting atoms in a chain or ring, said chain or ring comprising carbon atoms, and optionally, a heteroatom or heteroatoms which can be N, S, or O; and A is 0, 1, or 2.