Patent ID: 7642378

Claim:
A compound of formula (I) the N-oxides, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein p 1 , p 2 and p 3 are integers each independently from 1 to 3; p 4 is an integer zero or 1; each R 1 is independently selected from hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, hydroxy, mercapto, cyano, nitro, C 1-4 alkylthio or polyhaloC 1-6 alkyl, amino, C 1-4 alkylamino and di(C 1-4 alkyl)amino; each R 2 is independently selected from hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, or trifluoromethyl; R 3 is hydrogen or C 1-4 alkyl; each R 4 is independently selected from hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, or trifluoromethyl; Z is a bivalent radical of formula wherein X 1 and X 2 are each independently selected from CH, N or an sp 2 hybridized carbon atom; Z 1 is selected from CH 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 2 CH 2 O and OCH 2 CH 2 ; Z 2 is CH 2 or CH 2 CH 2 ; A represents C 1-6 alkanediyl substituted with one or two groups selected from aryl, heteroaryl and C 3-6 cycloalkyl; B represents a radical of formula (b-1) (b-2) (b-3) (b-4) (b-5) (b-6) (b-7) (b-8) (b-9) (b-10) (b-11) R 7 —O—C 1-6 alkanediyl-Y— (b-12) R 7 —S—C 1-6 alkanediyl-Y— (b-13) NC—C 1-6 alkanediyl-Y— (b-14) (b-15) (b-16) (b-17) (b-18) (b-19) (b-20) (b-21) (b-22) (b-23) (b-24) (b-25) (b-26) (b-27) (b-28) (b-29) (b-30) (b-31) (b-32) (b-33) R 12 —C 1-6 alkanediyl-Y— (b-34) (b-35) R 7 -“aminoacid”- (b-36) R 8 —O—C 1-6 alkanediyl-O—C 1-6 alkanediyl-Y— (b-37) wherein i is an integer 1 to 4; j is an integer 1 to 4; k is an integer 1 or 2; Y is O or NR 9 wherein R 9 is hydrogen, C 1-6 alkyl or C 1-4 alkylaminocarbonyl; R 7 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, or phenyl substituted with C 1-4 alkyl, halo, hydroxy or trifluoromethyl; R 8 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, or phenyl substituted with C 1-4 alkyl, halo, hydroxy or trifluoromethyl; R 10 and R 11 are each independently hydrogen or C 1-6 alkyl; optionally R 7 and R 9 can be taken together to form a bivalent radical of formula —(CH 2 ) 3 —, —(CH 2 ) 4 —, —(CH 2 ) 5 —, or —(CH 2 ) 6 —; R 12 is a radical of formula the amino acid is selected from the group consisting of glycine, alanine, valine, leucine, isoleucine, methionine, proline, phenylanaline, tryptophan, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartic acid, esters of aspartic acid, glutamic acid, esters of glutamic acid, lysine, arginine, and histidine; and optionally in radical (b-1) the C 1-6 alkanediyl moiety can be further substituted with phenyl, phenylC 1-4 alkyl, hydroxyphenylC 1-4 alkyl, C 1-4 alkyloxycarbonyl, C 1-4 alkyloxyC 1-4 alkyl, C 1-4 alkylthioC 1-4 alkyl, phenylC 1-4 alkylthioC 1-4 alkyl, hydroxyC 1-4 alkyl, thioC 1-4 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-4 alkyl, or a radical of formula