Patent ID: 8497075

Claim:
A method of identifying a modulator that inhibits the binding between 7,25-dihydroxycholesterol (7,25DHC), 7,27-dihydroxycholesterol (7,27DHC), 7-hydroxycholesterol (7HC) or 25-hydroxycholesterol (25HC) and Epstein-Barr Virus induced receptor 2 (EBi2), wherein said method comprises; (a) providing a candidate modulator; (b) incubating said modulator with 7,25DHC, 7,27DHC, 7HC or 25HC and EBi2; (c) determining whether the binding between 7,25DHC, 7,27DHC, 7HC or 25HC and EBi2 is inhibited in the presence of said candidate modulator compared to the binding between 7,25DHC, 7,27DHC, 7HC or 25HC and EBi2 in the absence of said candidate modulator.