Patent ID: 7902184

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: (a) R 1 is lower alkyl or C 3 -C 7 -cycloalkyl; (b) X, Y, and Z are defined in one of three groups selected from the group consisting of: (1) wherein X is N, Y is C and Z is N, (2) wherein X is N, Y is N and Z is C, and (3) wherein X is C, Y is N and Z is N; (c) R 2 is selected from the group consisting of: (1) lower alkyl, (2) lower halogenalkyl, (3) lower hydroxyalkyl, (4) lower alkoxyalkyl, (5) C 3 -C 7 -cycloalkyl or C 3 -C 7 -cycloalkyl substituted by phenyl or lower alkyl, (6) lower C 3 -C 7 -cycloalkylalkyl, (7) phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or lower halogenalkyl, (8) lower phenylalkyl wherein the phenyl ring is mono- or disubstituted by lower alkyl, lower alkoxy, halogen or lower halogenalkyl, and (9) —NR 3 R 4 ; (d) R 3 is hydrogen or lower alkyl, and R 4 is selected from the group consisting of: (1) lower alkyl, (2) lower alkoxyalkyl, (3) C 3 -C 7 -cycloalkyl or C 3 -C 7 -cycloalkyl substituted by phenyl, (4) lower C 3 -C 7 -cycloalkylalkyl, (5) unsubstituted phenyl or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or lower halogenalkyl, (6) lower phenylalkyl wherein the phenyl ring is unsubstituted or mono- or disubstituted by lower alkyl, lower alkoxy, halogen or lower halogenalkyl, and (7) indanyl; or alternatively, R 3 and R 4 together with the nitrogen atom to which they are attached form a 4-, 5-, 6- or 7-membered saturated or partly unsaturated heterocyclic ring optionally containing a further heteroatom of nitrogen, oxygen or sulfur; wherein said heterocyclic ring is optionally substituted by one, two or three substituents independently selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halogen and halogenalkyl; or said heterocyclic ring is optionally condensed with a phenyl or cyclohexyl ring, wherein said phenyl or cyclohexyl ring is optionally substituted by one, two or three substituents independently selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, halogen and halogenalkyl.