Patent ID: 8703745

Claim:
A method of treating a disorder associated with sphingosine-1-phosphate (S1P) receptor modulation, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I wherein: R 1 is N or C—R 10 ; R 2 is aromatic heterocycle, non-aromatic heterocycle, cycloalkyl, cycloalkenyl or aryl; R 3 is O; R 4 is H or aryl; R 5 is H, halogen, —OC 1-3 alkyl; R 6 is H, halogen or C 1-3 alkyl; R 7 is H or C 1-6 alkyl; R 8 is H; R 9 is —OPO 3 H 2 , —P(O)(OH) 2 , —S(O) 2 OH, —P(O)MeOH, or —OR 15 ; R 10 is H, C 1-6 alkyl; R 15 is H or C 1-3 alkyl; L is CHR 16 ; a is 0, 1, 2, 3, 4 or 5; b is 0, 1, 2, 3, 4 or 5; c is 0 or 1; d is 0, 1, 2 or 3; R 16 is H, C 1-3 alkyl, —OC 1-3 alkyl, halogen, hydroxyl or amino, and with the proviso: when R 9 is OR 15 then d is not 1.