Patent ID: 7101978

Claim:
A TNF-α binding molecule selected from the group consisting of: (i) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1, and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3; (ii) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31L and S54Y substitutions, and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3 with T28K and E61R substitutions; (iii) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31L and S54Y substitutions, and further comprising a heavy chain variable region corny rising a polypeptide with SEQ ID NO: 3 with T28P and E61R substitutions, (iv) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31L and M55R substitutions, and further comprising a heavy chain variable region a polypeptide with SEQ ID NO: 3 with T28K, I53M and E61R substitutions; (v) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31and M55R substitutions, and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3 with T28P, I53M and E61R substitutions; (vi) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31M and M55K substitutes and, and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3 with T28K, I53M and E61R substitutions; (vii) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31M and M55K substitutions, and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3 with T28P, 153M and E61R substitutions; (viii) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31Y sod M55R substitutions (SEQ ID NO:5), and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3 with T28K and I53M substitutions (SEQ ID NO: 7); and (ix) an antibody or antibody fragment comprising a light chain variable region comprising a polypeptide with SEQ ID NO: 1 with S31Y and M55R substitutions and further comprising a heavy chain variable region comprising a polypeptide with SEQ ID NO: 3 with T28P and I53M substitutions.