Patent ID: 8329191

Claim:
A three-branched PEG-G-CSF conjugate of the following general formula (1): in which a bonding ratio of three-branched polyethylene glycol(PEG) and G-CSF is 1:1 (mol/mol), and PEG has an average molecular weight of about 23,000 daltons, wherein, n is an integer of 1 to 1,000; m is an integer of 10 to 1,000; Z is (CH 2 )s or (CH 2 ) s NHCO(CH 2 )s as a linker of G-CSF and PEG wherein S is an integer of 1 to 6; Y is an amide bond formed by combining NH 2 functional group in G-CSF and a functional group of PEG derivative.