Patent ID: 7459473

Claim:
A method of stimulating neuronal regeneration and growth in a mammal having peripheral neuropathies caused by physical injury or disease state, physical damage to the brain, physical damage to the spinal cord, stroke associated with brain damage, or neurological disorders relating to neurodegeneration, comprising: administering to the animal an effective amount of a compound to stimulate growth of damaged peripheral nerves or to promote neuronal regeneration, where the compound has the formula (I): where n is 1; R 1 is selected from the group consisting of hydrogen, C 1 -C 9 straight or branched chain alkyl, C 2 -C 9 straight or branched chain alkenyl, aryl, heteroaryl, carbocycle, and heterocycle; D is selected from the group consisting of a bond, C 1 -C 10 straight or branched chain alkylene, C 2 -C 10 alkenylene, and C 2 -C 10 alkynylene; R 2 is selected from the group consisting of: wherein said alkyl, alkenyl, alkylene, alkenylene, alkynylene, aryl, heteroaryl, carbocycle, heterocycle, or R 2 is optionally substituted with one or more substituents selected from R 3 , where R 3 is selected from the group consisting of hydrogen, hydroxy, halo, haloalkyl, thiocarbonyl, alkoxy, alkenoxy, alkylaryloxy, aryloxy, arylalkyloxy, cyano, nitro, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, alkylthio, sulfonyl, C 1 -C 6 straight or branched chain alkyl, C 2 -C 6 straight or branched chain alkenyl or alkynyl, aryl, heteroaryl, carbocycle, heterocycle, and CO 2 R 4 where R 4 is selected from the group consisting of hydrogen, C 1 -C 9 straight or branched chain alkyl, and C 2 -C 9 straight or branched chain alkenyl; or a pharmaceutically acceptable salt thereof.