Patent ID: 8211934

Claim:
A method for treating melanoma, lung carcinoma, or mesothelioma in a patient comprising administering to the patient, a therapeutically effective amount of a compound of the formula in which: n is 0, 1 or 2; X 1 is NH, N(CH 3 ), or N(C 2 H 5 ); R 0 is selected from the group consisting of C 1 -C 3 alkyl, cyclopropyl, halo, OR 5 and S(O) m R 5 in which m is 0, 1 or 2; R 1 and R 2 are independently selected from the group consisting of phenyl, alkyl, C 2 -C 8 alkenyl, phenylcyclopropyl, phenylpropenyl, R 6 —X 2 —C(R 8 )(R 9 )—R 7 —, R 6 —X 2 —N(R 8 )—R 7 —, and R 10 X 3 R 7 —; R 3 and R 4 are independently hydrogen, methyl or ethyl; R 5 is methyl or ethyl; R 6 is selected from the group consisting of hydrogen, C 1 -C 10 alkyl, aryl, W, Y, NH 2 , NHCONR 3 R 4 , NHCOOR 3 and NHSO 2 R 9 ; R 7 is selected from the group consisting of a direct bond, an alkyl group having from 1 to 10 carbon atoms, aryl, —(NH) p (CH 2 CH 2 O) q (NH) p — in which p is 0 or 1 and q is an integer from 1 to 4, and W; R 8 is selected from the group consisting of H, Y, OH, —NHCON 3 R 4 ; —NHCOOR 3 ; —NHSO 2 R 9 , —(CH 2 ) r CO 2 R 3 , and (CH 2 ) r CONR 3 R 4 in which r is an integer from 1 to 3; R 9 is aryl or C 1 -C 6 alkyl; R 10 is selected from C 1 -C 10 alkyl, aryl and W; X 2 is selected from the group consisting of a direct bond, —NH—, —N(CH 3 )—, —NCONR 3 R 4 , —NCOOR 3 , and —NSO 2 R 9 ; X 3 is selected from O, S, SO and SO 2 ; W is a saturated carbocyclic or heterocyclic group; Y is selected from the group consisting of COOH, COOR 3 , CONR 3 R 4 , CONHSO 2 R 5 , hydroxymethyl, —CH 2 COOH, CH 2 CONR 3 R 4 ; and 5-tetrazolyl; and hydrates and salts thereof, and labeled derivatives thereof.