Patent ID: 7399645

Claim:
A bioconjugation system, comprising a sterically constrained cis-diol and a borate represented respectively by: wherein: R 1 is C2-C16 alkyl ether, C1-C16 alkoxy or C1-C16 alkyl; R 1 is an aryl, aralkyl, C1-C16 alkyl, or C1-C16 alkoxy group; wherein the cis-diol and borate are bonded through the hydroxyl groups to form a conjugate represented by: X is —NH—, —C(O)NH—, —NHC(O)— or —S—; X′ is a bond, —O—, —S—, —C(O)—, —C(O)O—, —S(O)—, —OSO 2 —, —S(O 2 )O—, —SO 2 —, —NR 3 —, —NR 3 C(O)—, —C(O)NR 3 C—, —R 3 NNR 3 SO 2 —, —SO 2 NR 3 NR 3 —, —NR 3 SO 2 —, —SO 2 NR 3 —, —CR 3 2 C(O)NR 3 —, —NR 3 C(O)CR 3 2 , —CR 3 2 C(O)—, —C(O)CR 3 2 —, —R 3 NNR 3 —, —NR 3 NR 3 —, —R 3 NNR 3 2 —, —NR 3 2 NR 3 —, —CR 3 2 Ph—, —PhCR 3 2 —, —C(NR 3 )NR 3 —, or —NR 3 C(NR 3 )—; each R 3 is independently —H, alkyl, alkoxy, aryloxy or arylalkoxy; Y is a solid support; Y′ is a bioactive molecule comprising one or more peptides; n is an integer from 10 to 10 10 ; and n′ is an integer from 1 to 200.