Patent ID: 8535799

Claim:
A method for preparing particulate material, comprising: (i) spraying a first hydrophilic composition on a second composition, where the second composition is at a temperature at least about 10° C. below the melting point of the first composition, wherein the first hydrophilic composition consists essentially of a hydrophilic carrier in liquid form, wherein the carrier has a melting point of at least about 5° C., the second composition comprises a material in solid form, and the second composition comprises one or more therapeutically or prophylactically active substances, and (ii) agglomerating the composition by mixing the resulting composition to obtain particulate material; wherein the therapeutically or prophylactically active substance has an aqueous solubility of at most about 3 mg/ml at 25° C. and a pH of about 7.4 and wherein the particulate material obtained has a geometric weight mean diameter d gw of between about 20 micrometers and about 2000 micrometers.