Patent ID: 7361680

Claim:
A method of treating prostate cancer in a patient in need thereof comprising administering to said patient an effective amount of a compound of formula (I): wherein R 1 is lower alkyl, lower alkenyl, lower alkynyl, phenyl, benzyl or 2-thienyl, R 2 , R 3 , R 4 and R 5 are the same or different and are each hydrogen or lower alkyl; each R 6 is individually hydrogen, lower alkyl, hydroxy, (hydroxy)lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, n is 1-3, R 7 is hydrogen, lower alkyl or lower alkenyl, X is oxy or thio, Y is (CH 2 ) 1-3 , (CH 2 ) 1-3 SO 2 or (CH 2 ) 1-3 C(O), and Z is (ω-(4-pyridyl)(C 2 -C 4 alkoxy), (ω-((R 8 )(R 9 )amino)(C 2 -C 4 alkoxy), an amino acid ester of (ω-(HO)(C 2 -C 4 ))alkoxy, N(R 8 )CH(R 8 )CO 2 H, 1′-D-glucuronyloxy, OH, (C 2 -C 4 )acyloxy, SO 3 H, PO 4 H 2 , N(NO)(OH), SO 2 NH 2 , PO(OH)(NH 2 ), OCH 2 CH 2 N(CH 3 ) 3 + , amino, lower alkylamino, di(lower alkyl)amino, phenylamino, or tetrazolyl; wherein R 8 and R 9 are each H, (C 1 -C 3 )alkyl or together with N, are a 5- or 6-membered heterocyclic ring having 1-3 N(R 8 ), S or nonperoxide O; or Y-Z is (CH 2 ) 1-3 R 10 wherein R 10 is OH, (C 2 -C 4 )acyloxy, SO 3 H, PO 4 H 2 , N(NO)(OH), SO 2 NH 2 , PO(OH)NH 2 .