Patent ID: 7314880

Claim:
A method of reducing ischemic damage in cardiac tissue in a subject comprising: administering to the subject in need thereof an effective amount of a composition comprising a non-analgesic diarylmethylpiperazine compound of the general formula: wherein: Z is selected from the group consisting of: hydrogen; halogen; C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl; C 1 -C 6 haloalkyl; C 1 -C 6 alkoxy; C 3 -C 6 cycloalkoxy; sulfides of the formula SR 8 where R 8 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, arylalkyl having a C 5 -C 10 aryl moiety and an C 1 -C 6 alkyl moiety, or C 5 -C 10 aryl; sulfoxides of the formula SOR 8 where R 8 is the same as above; sulfones of the formula SO 2 R 8 where R 8 is the same as above; nitrile; C 1 -C 6 acyl; alkoxycarbonylamino (carbamoyl) of the formula NHCO 2 R 8 where R 8 is the same as above; carboxylic acid, or an ester, amide, or salt thereof; aminomethyl of the formula CH 2 NR 9 R 10 where R 9 and R 10 may be the same or different, and may be hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 hydroxyalkyl, C 2 -C 6 methoxyalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 10 aryl, or R 9 and R 10 together may form a ring of 5 or 6 atoms, the ring atoms selected from the group consisting of N and C; carboxamides of the formula CONR 9 R 10 where R 9 and R 10 are the same as above, or C 2 -C 30 peptide conjugates thereof; and sulfonamides of the formula SO 2 NR 9 R 10 where R 9 and R 10 are the same as above; and X is selected from the group consisting of hydrogen, hydroxyl, halogen and alkoxy, or a pharmaceutically acceptable ester or salt thereof.