Patent ID: 8173433

Claim:
A method for determining a change in endogenous angiogenic activity of a subject, the method comprising: (a) detecting expression of one or more platelet-associated biomarkers in a platelet sample from the subject, wherein expression of at least one detected biomarker is modified in relation to the change in endogenous angiogenic activity; and (b) correlating the expression of at least one detected biomarker with the change in endogenous angiogenic activity by comparing the expression of the detected biomarker with previously determined expression for the same biomarker, wherein the platelet-associated biomarker is selected from the group consisting of connective tissue activating protein III (CTAP III), apolipoprotein A1, and IL-8, and wherein the change in endogenous angiogenic activity of the subject is categorized as dormant, aggressive, sustained aggressive, regressive or no change.