Patent ID: 8741906

Claim:
A compound of formula (I) wherein A is selected from the group consisting of alkyl, hydroxyalkyl, —CH 2 C(O)—, —C(O)—, —SO 2 — and a bond; R 1 is selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyl, alkoxy, haloalkoxy, phenyl, halophenyl, alkoxyphenyl, haloalkylphenyl, haloalkoxyphenyl, (halo)(haloalkyl)phenyl, cyanophenyl, hydroxyalkoxyphenyl, alkylsulfonylphenyl, alkylsulfonylaminophenyl, cyano, cycloalkyl, cycloalkylalkoxy, amino, (alkylsulfonyl)(alkyl)[1,2,4]triazolyl, (halo)(dialkylamino)pyridinyl, (alkyl)(oxy)pyridinyl, nitro-benzo[1,2,5]oxadiazolylaminopyridinyl, heterocyclyl, alkylheterocyclyl, hydroxyheterocyclyl, alkylheterocyclyl, heteroaryl, haloheteroaryl, alkylheteroaryl, cycloalkylheteroaryl and haloalkylheteroaryl, wherein said heterocyclyl is a three to eight membered carbocyclic ring comprising at least one nitrogen or oxygen atom, and wherein said heteroaryl is pyridinyl, pyrazolyl, oxadiazolyl, furazanyl, tetrazolyl or triazolyl; R 2 is selected from the group consisting of halogen, —NR 3 R 4 and —OR 5 ; one of R 3 and R 4 is hydrogen or alkyl and the other one is alkyl or cycloalkyl; or R 3 and R 4 together with the nitrogen atom to which they are attached form heterocyclyl or substituted heterocyclyl, wherein said heterocyclyl is morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, 2-oxa-6-azaspiro[3.3]heptyl, azetidinyl, thiazolidinyl, thiomorpholinyl, dioxothiomorpholinyl, oxazepanyl, 2-oxa-6-azaspiro[3.4]octyl, 6-oxa-1-azaspiro[3.3]heptyl, 2-oxa-5-aza-spiro[3.4]octyl, isoxazolidinyl, aziridinyl, dioxoisothiazolidinyl or oxopyrrolidinyl and wherein said substituted heterocyclyl is heterocyclyl substituted with one to four substituents independently selected from the group consisting of alkyl, halogen, hydroxyl, alkoxy, hydroxyalkyl, carboxyl, alkoxyalkyl, cyano, alkylamino, dialkylamino, alkylcarbonylamino, alkylcarbonyl(alkylamino), phenyl, alkoxycarbonyl, aminoalkyl, alkylpyrazolyl or alkylisoxazolyl; and R 5 is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl and oxetanyl; or a pharmaceutically acceptable salt or ester thereof; with the proviso that said compound is not 3-[(2-chlorophenyl)methyl]-5-(1,1-dimethylethyl)-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine or N-cyclopropyl-5-(1,1-dimethylethyl)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine.