Patent ID: 7815912

Claim:
A method of controlled ovarian hyperstimulation in a mammalian female, said method comprising the co-administration to said female of: a substance having follicle stimulating hormone activity (FSH substance) in an amount effective to stimulate multiple follicular development, said FSH substance selected from the group consisting of recombinant FSH (recFSH) and urinary FSH (uFSH); a gonadotropin releasing hormone (GnRH) antagonist in an amount equivalent to a daily subcutaneous dose of 1.0-4.0 mg ganirelix to prevent a premature LH-surge, said GnRH antagonist selected from the group consisting of ganirelix, cetrorelix, and mixtures thereof; and an LH substance being recombinant LH (recLH) in an amount equivalent to a daily subcutaneous dose of between 1 and 40 I.U. recLH per kg of bodyweight to prevent or supress symptoms of luteinising hormone (LH) deficiency resulting from the admistration of the GnRH antagonist; followed by the administration of a meiosis and luteinisation inducing substance (ML substance) in an amount effective to stimulate resumption of meiosis and luteinisation, said ML substance selected from the group consisting of recLH, urinary chorionic gonadotropin (uCG), recombinant CG, and mixtures thereof.