Patent ID: 7041302

Claim:
A method of inducing tumor cell death in a human patient by inducing a type 1 inflammatory response in a solid tumor, the method comprising i) locally administering an antigen-releasing agent to a solid tumor in the patient, whereby a tumor antigen is released from cells of the tumor; iia) locally administering to the tumor a leukocyte attractant, whereby leukocytes are induced to infiltrate the tumor; and iib) locally administering to the tumor interferon-gamma (IFN-g) as a first tyne 1 inflammatory response promoting agent and a second type 1 inflammatory response-(IR1-)promoting agent selected from the group consisting of tumor necrosis factor-beta (TNF-b), tumor necrosis factor-alpha (TNF-a), interleukin-2 (IL-2), interleukin-12 (IL-12), and a mixture thereof whereby a type 1 inflammatory response is induced in the tumor and tumor cell death is induced.