Patent ID: 8372849

Claim:
A compound of the following formula: wherein each Q and U is CH or N, provided that one of Q and U is N; each of X, Y, and Z, independently, is C 1-5 alkylene or deleted; m is 0, 1, 2, 3, 4, or 5; n is 1; p is 1 or 2; R 1 is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 1 -C 20 heterocycloalkyl, aryl, heteroaryl, halo, CN, OR a , COOR a , OC(O)R a , C(O)R a , C(O)NR a R b , or NR a R b ; R 2 is C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 1 -C 20 heterocycloalkyl, aryl, heteroaryl, or C 1 -C 10 alkyl, optionally substituted with C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 1 -C 20 heterocycloalkyl, or N(R c R d ); R 3 , independently, is C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 1 -C 20 heterocycloalkyl, aryl, heteroaryl, halo, CN, OR e , COOR e , OC(O)R e , C(O)R e , C(O)NR e R f , or NR e R f ; or R 3 is C 1-5 alkylene bonded to two carbon atoms of the ring to which it is attached or C 2-8 alkylene bonded to one carbon atom of the ring to which it is attached; and R 4 is P(═O)(OR g )(OR i ), P(═O)(NHR g )(OR i ), P(═O)(NR g )(NR i ), S(═O) 2 OR g , or S(═O) 2 R g ; in which each of R a , R b , R c , R d , R e , R f , R g and R i , independently, is H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 1 -C 20 heterocycloalkyl, aryl, heteroaryl, or —C(O)R, R being H, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, C 1 -C 20 heterocycloalkyl, aryl, or heteroaryl; or R a and R b are linked and together form C 2-8 alkylene, R c and R d are linked and together form C 2-8 alkylene, R e and R f are linked and together form C 2-8 alkylene, or R g and R i are linked and together form C 1-5 alkylene.