Patent ID: 7303757

Claim:
A fluid phase invertible composition that goes from a first fluid state to a second non-fluid state in which said composition is incapable of fluid flow, wherein said composition is produced by combining: (a) a fluid substrate comprising a proteinaceous material, wherein said proteinaceous material comprises one or more of: albumin, elastin, fibrin and soluble and insoluble forms of collagen and combinations thereof, and (b) a heat stabilized dialdehyde crosslinking agent that has been produced by maintaining an initial dialdehyde crosslinking composition at a temperature ranging from about 45 to about 55° C. for a period of time ranging from about 1 to about 20 days, wherein said heat stabilized crosslinking agent has been heat stabilized prior to contacting said substrate; wherein said fluid phase invertible composition goes from a first fluid state to a second non-fluid state in which said composition is incapable of fluid flow in a period of time ranging from about 10 seconds to about 10 minutes following crosslinking-of said substrate by said heat stabilized dialdehyde crosslinking agent.