Patent ID: 8653067

Claim:
A method for treating Alzheimer's disease, comprising: administering a composition in an amount effective for treating Alzheimer's disease to a subject in need thereof, wherein the composition contains a compound represented by the general formula (I): wherein ring A is R 9 and R 10 are each independently a hydrogen atom, halogen, hydroxy, cyano, nitro, mercapto, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted acyloxy, carboxy, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkoxycarbonyloxy, optionally substituted lower aryloxycarbonyloxy, optionally substituted amino, optionally substituted carbamoyl, optionally substituted carbamoyloxy, optionally substituted lower alkylthio, optionally substituted arylthio, optionally substituted lower alkylsulfonyl, optionally substituted arylsulfonyl, optionally substituted lower alkyl sulfinyl, optionally substituted arylsulfinyl, optionally substituted lower alkylsulfonyloxy, optionally substituted arylsulfonyloxy, optionally substituted sulfamoyl, an optionally substituted carbocyclic group, optionally substituted carbocyclicoxy, an optionally substituted heterocyclic group, or optionally substituted heterocyclicoxy; G is wherein Q 1 and Q 2 are each independently a bond, optionally substituted lower alkylene, or optionally substituted lower alkenylene; W 1 is O or S; R 12 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, lower alkoxycarbonyl lower alkyl, carbocyclic lower alkyl, or acyl; ring B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, wherein Alk 1 is lower alkylene or lower alkenylene; R 0 is a hydrogen atom, lower alkyl, or acyl; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; each of R 2a and R 2b is a hydrogen atom, R 3a , R 3b , R 4a , and R 4b are each independently a hydrogen atom, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted acyl, carboxy, optionally substituted lower alkoxycarbonyl, optionally substituted amino, optionally substituted carbamoyl, an optionally substituted carbocyclic group, or an optionally substituted heterocyclic group; n is 2 and m is 0; each R 3a , each R 3b , each R 4a , and each R 4b may be independently different; R 5 is optionally substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.