Patent ID: 7741362

Claim:
A compound of Formula II or a pharmaceutically acceptable salt or ester thereof, wherein Q is 1) H, 2) aryl or 3) heteroaryl, wherein aryl and heteroaryl are unsubstituted or substituted with 1 to 4 substituents selected from R a , or 4) a group of formula wherein R4 is 1) H, 2) (C 1 -C 6 )alkyl, 3) (C 2 -C 6 )alkenyl, 4) (C 2 -C 6 )alkynyl, 5) Cy, 6) Cy-(C 1 -C 6 )alkyl, 7) Cy-(C 2 -C 6 )alkenyl or 8) Cy-(C 2 -C 6 )alkynyl, wherein alkyl, alkenyl, alkynyl and Cy are unsubstituted or substituted with 1 or 2 substituents selected from R d , R5 is 1) H, 2) (C 1 -C 6 )alkyl, 3) (C 2 -C 6 )alkenyl, 4) (C 2 -C 6 )alkynyl, 5) aryl, 6) aryl-(C 1 -C 6 )alkyl, 7) heteroaryl or 8) heteroaryl-(C 1 -C 6 )alkyl, wherein aryl and heteroaryl are unsubstituted or substituted with 1 to 4 substituents selected from R d , or R4 and R5 together with the atom to which they are attached form a 3- to 8-membered ring containing 0 to 2 heteroatoms selected from the group consisting of N, O and S, wherein said ring is unsubstituted or substituted with 1 to 3 substituents selected from R d , or said ring is fused to aryl or heteroaryl, either of which is unsubstituted or substituted with 1 to 3 substituents selected from R d ; A is 1) H, 2) (C 1 -C 6 )alkyl or 3) (C 3 -C 5 )cycloalkyl; B is independently 1) H, 2) halogen or 3) (C 1 -C 6 )alkyl, or symbols B together form a double or triple bond between the atoms to which they are attached; R1 is 1) H, 2) (C 1 -C 6 )alkyl or 3) (C 3 -C 7 )cycloalkyl; R2 is independently 1) H, 2) (C 1 -C 6 )alkyl, 3) (C 2 -C 6 )alkenyl, 4) (C 2 -C 6 )alkynyl, 5) (C 3 -C 7 )cycloalkyl or 6) (C 3 -C 7 )cycloalkyl(C 1 -C 6 )alkyl, or symbols R2 together with the nitrogen to which they are attached form a saturated 5- to 7-membered ring containing 1 or 2 heteroatoms selected from the group consisting of N, O and S; R3 is 1) H, 2) (C 1 -C 6 )alkyl, 3) (C 2 -C 6 )alkenyl, 4) (C 2 -C 6 )alkynyl or 5) (C 3 -C 7 )cycloalkyl; R6 is independently 1) H, 2) halogen, 3) —NO 2 , 4) —NR b R b , 5) —CN, 6) —OR b , 7) —SR b , 8) —C(O)R b , 9) (C 1 -C 6 )alkyl, 10) (C 2 -C 6 )alkenyl, 11) (C 2 -C 6 )alkynyl, 12) (C 3 -C 7 )cycloalkyl or 13) —CF 3 ; R a is independently 1) H, 2) halogen, 3) —OR b , 4) (C 1 -C 6 )alkyl or 5) —CF 3 ; R b is independently 1) hydrogen, 2) (C 1 -C 6 )alkyl, 3) (C 2 -C 6 )alkenyl, 4) (C 2 -C 6 )alkynyl, 5) Cy or 6) Cy-(C 1 -C 4 )alkyl; R d is independently 1) a group selected from R c , 2) (C 1 -C 6 )alkyl, 3) (C 2 -C 6 )alkenyl, 4) (C 2 -C 6 )alkynyl, 5) aryl, 6) aryl-(C 1 -C 6 )alkyl, 7) heteroaryl-(C 1 -C 6 )alkyl, 8) (C 3 -C 7 )cycloalkyl or 9) heterocyclyl, wherein alkyl, alkenyl, alkynyl, aryl and heteroaryl are unsubstituted or substituted with 1 to 4 substituents independently selected from R c ; R c is independently 1) a group selected from R a , 2) —NO 2 , 3) —SR b , 4) —NR b R b , 5) —CN or 6) —NR b C(O)R b ; Cy is cycloalkyl, heterocyclyl, aryl or heteroaryl; t is an integer from 0 to 3; n is the integer 1 or 2; X is a bond or C(R6); and L is C(R6), S or N.