Patent ID: 7037902

Claim:
A pharmaceutical composition comprising in an effective amount for modulating EPO-R activity: a non-peptide organic molecule of from 12 to 36 atoms other than hydrogen, from 9 to 20 carbon atoms, from 4 to 12 of the heteroatoms chalcogen, nitrogen, halogen, and metal ion of Groups I or II of the periodic chart, wherein said non-peptide organic molecule is of the formula (1): wherein: X is of from 1 to 3 atoms other than hydrogen, and is amino, alkyl substituted amino, oxygen, or sulfur bonded to 0 to 2 oxygen atoms; n is 0 or 1; R 1 is substituted phenyl having from 0 to 3 substituents that are CH 3 , Cl, NO 2 , or CF 3 , and R 1 is optionally bonded directly to an annular carbon atom or through a linking group of from 1 to 3 carbon and nitrogen atoms or N-hydroxyamidinyl; R 2 is CH 3 , NH 2 , OH, or aroylamido of from 7 to 8 carbon atoms having optional substituents that are CH 3 , Cl, NO 2 , or CF 3 ; R 3 is H, carboxy, or unsubstituted or halo substituted cycloalkylalkyl of from 4 to 8 carbon atoms, having from 3 to 4 annular atoms; R 4 is H, unsubstituted or halo substituted lower alkyl of from 1 to 3 carbon atoms, or alkoxymethyl of from 2 to 4 carbon atoms; with the proviso that R 3 and R 4 may be taken together to define 1,2-dimethylene-alpha-halo, or alpha-CH 3 -halobenzene, where halo is F or Cl; and a pharmaceutically acceptable vehicle.