Patent ID: 7029680

Claim:
A method of stimulating or enhancing a CTL response to a biologically active molecule in a mammalian subject in need of such CTL response stimulation and enhancement, comprising administering to said subject by injection into the body of said subject, in a manner so as to elicit a CTL response, an effective amount of a composition comprising the biologically active molecule, either entrapped within the interior of an HBsAg particle or exposed or present at the surface of an HBsAg particle by incubating said HBsAg particle at a temperature of about 35° C. to about 60° C. in an aqueous medium in the presence of the biologically active molecule, wherein said biologically active molecule is not covalently attached to said HBsAg particle, and wherein said CTL response is enhanced relative to that produced by the biologically active molecule alone.