Patent ID: 8541421

Claim:
A method of enhancing the sweet taste of a comestible composition comprising contacting the comestible composition with a compound of Formula (IIa): or a pharmaceutically acceptable salt thereof; wherein: A is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —CN, —OR 9 , —S(O) c R 9 , —NR 9 COR 10 , —NHOR 9 , —NR 9 R 10 , —CONR 9 R 10 , —CO 2 R 9 , —NR 9 CO 2 R 10 , —NR 9 CONR 10 R 11 , —NR 9 CSNR 10 R 11 , or —NR 9 C(═NH)NR 10 R 11 ; R 17 is hydrogen, alkyl, or substituted alkyl; B is —N—; Y forms a single bond with W and a double bond with Z; W is —S—; Y is —C(R 26 )—; Z is —C(R 27 )—; R 26 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —OR 31 , —OCOR 31 , —NR 31 R 32 , —CONR 31 R 32 , or —CO 2 R 31 ; R 27 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —OR 33 , —OCOR 33 , —NR 33 R 34 , —CONR 33 R 34 , or —CO 2 R 33 ; R 9 , R 10 , R 11 , R 19 , R 31 , R 32 , R 33 , and R 34 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; alternatively R 9 and R 10 , R 10 and R 11 , R 31 and R 32 , or R 33 and R 34 , together with the atoms to which they are bonded, form a cycloheteroalkyl or substituted cycloheteroalkyl ring; wherein the substituted acyl, substituted alkyl, substituted cycloheteroalkyl, substituted aryl, substituted arylalkyl, substituted heteroalkyl, substituted heteroaryl, and substituted heteroarylalkyl, and substituted cycloheteroalkyl each independently comprises one or more substituent groups selected from the group consisting of —R a , halo, ═O, —OR b , —SR b , ═S, —NR c R c , ═NR b , ═N—OR b , trihalomethyl, —CN, —NO 2 , —S(O) 2 R b , —S(O) 2 NR b , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 OR b , —P(O)(OR b )(OR b ), —C(O)R b , —C(NR b )R b , —C(O)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC(O)OR b , —NR b C(O)R b , —NR b C(O)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b and —NR b C(NR b )NR c R c , where R a is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; each R b is independently hydrogen or R a ; and each R c is independently R b or alternatively, the two R c s are taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered cycloheteroalkyl; and the comestible composition comprises at least one sweetener selected from the group consisting of sucrose and sucralose.