Patent ID: 8247413

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein X 1 is CR 1 ; X 2 is CR 2 ; X 3 is N; X 4 is N; X 5 is N ; Z 1 is O; Z 2 is NH; L is selected from the group consisting of alkenylenyl, alkylenyl, alkynylenyl, cycloalkylenyl, —(CH 2 ) m O(CH 2 ) n —, and N(R Y ), wherein the left end of —(CH 2 ) m O(CH 2 ) n — is attached to Z 2 and the right end is attached to R 9 ; m and n are each independently 1-6; R Y is selected from the group consisting of hydrogen and alkyl; R 1 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, —NR A S(O) 2 R B , —S(O) 2 R B , —NZ A Z B , (NZ A Z B )alkyl, (NZ A Z B )carbonylalkyl and (NZ A Z B )sulfonyl, wherein Z A and Z B are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, and arylalkyl; R 2 is selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, allyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, —NR A S(O) 2 R B , —S(O) 2 OR A , —S(O) 2 R B , —NZ A Z B , (NZ A Z B )alkyl, (NZ A Z B )alkylcarbonyl, (NZ A Z B )carbonyl, (NZ A Z B )carbonylalkyl, and (NZ A Z B )sulfonyl; R A is selected from the group consisting of hydrogen and alkyl; R B is selected from the group consisting of alkyl, aryl, and arylalkyl; R 8a , is selected from the group consisting of hydrogen and alkyl; R 8b is absent; and R 9 is selected from the group consisting of hydrogen, aryl, cycloalkyl, and heterocyclyl.