Patent ID: 7632980

Claim:
A method for producing Plasmodium falciparum protein MSP-1 in milk of a non-human transgenic mammal, comprising: 1) providing a non-human transgenic mammal whose genome comprises a modified nucleic acid sequence encoding said MSP-1 operably linked to a promoter which directs expression in a mammary gland and a signal sequence directing secretion of said MSP-1 into milk, wherein said modified nucleic acid sequence has been modified by replacing a number of AT-containing codons of a nucleic acid sequence encoding said MSP-1, as it naturally occurs in Plasmodium falciparum , with a codon or codons preferred by a mammalian cell for the purpose of expression and encoding the same amino acid as the replaced AT-containing codon or codons, wherein the number of codons replaced is sufficient to allow expression of said MSP-1 in said non-human transgenic mammal; and 2) allowing said non-human transgenic mammal to express said MSP-1 in its milk.