Patent ID: 6900020

Claim:
A method for selecting of a substance capable of controlling activation of prorenin, said prorenin being non-proteolytically activated to have renin-like activity by protein-protein interaction in the profragment region of prorenin without alteration in a primary structure, wherein said method comprising: a) providing prorenin, b) providing an antibody able to activate prorenin non-proteolytically to have renin-like activity by interacting with the profragment region of prorenin, c) providing a candidate substance, and d) measuring the renin-like activity of prorenin activated by the antibody provided in step (b) in the presence of the candidate substance, comparing said activity with the renin-like activity of prorenin activated by the antibody provided in the absence of the candidate substance, and selecting the candidate substance if there is an inhibition of the renin-like activity of prorenin in the presence of the candidate substance in comparison to the renin-like activity of prorenin in the absence of the candidate substance.