Patent ID: 8546440

Claim:
A compound of formula (I) or a stereoisomeric form thereof, wherein R 0 is hydrogen, or C 1-4 alkyl; R 1 is hydrogen, or C 1-4 alkyl; X is CR 7 or N; wherein R 7 is hydrogen; A 1 is CR 2 or N; A 2 is CR 8 or N; A 3 and A 4 each independently are CH or N; provided that no more than two of A 1 , A 2 , A 3 and A 4 are N; R 2 is hydrogen, halo or C 1-4 alkyloxy; R 8 is hydrogen or halo; R 3 is hydrogen; C 1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of hydroxyl, halo, morpholinyl, piperidinyl, pyrrolidinyl, tetrahydropyranyl, Ar, C 1-6 alkyloxy, cycloC 3-7 alkyloxy, and cycloC 3-7 alkyl; carboxyl; C 2-4 alkenyl; NR 5 R 6 -carbonyl; cycloC 3-7 alkyl; Ar; tetrahydropyranyl; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; or Ar—O—CH 2 —; wherein each Ar independently is phenyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy, cyano, NR 5 R 6 , morpholinyl, C 1-4 alkyl, and C 1-4 alkyl substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy, and NR 5 R 6 ; benzimidazolyl optionally substituted with one or more substituents each independently selected from C 1-4 alkyl; or pyridinyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy, cyano, C 1-4 alkyl, and C 1-4 alkyl substituted with one or more substituents each independently selected from halo; each R 5 independently is hydrogen, C 1-4 alkyl, C 1-6 alkylcarbonyl, or C 1-4 alkyloxy(CH 2 CH 2 O) n —CH 2 -carbonyl; n is an integer selected from 1, 2, 3, 4, 5 or 6, each R 6 independently is hydrogen or C 1-4 alkyl; R 4 is hydrogen; cyano; halo; phenyl optionally substituted with one or more substituents each independently selected from the group consisting of halo and phenyl; phenylcarbonyl optionally substituted with one or more substituents each independently selected from halo; C 1-4 alkyloxy; C 1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, NR 5 R 6 , C 1-4 alkyloxy, hydroxyl, and formylamino; Y 1 is CH; Y 2 is CR 9 ; Y 3 is CH; R 9 is hydrogen; halo; tetrahydropyranyl; C 2-4 alkenyl; phenyl optionally substituted with one or more substituents each independently selected from C 1-4 alkyloxy; or C 1-4 alkyl optionally substituted with one or more substituents each independently selected from halo; or a pharmaceutically acceptable addition salt or a solvate thereof.