Patent ID: 7195761

Claim:
A humanized antibody comprising: (a) a light chain comprising a light chain variable region comprising the following sequence: (SEQ ID NO:7) 1 5 10 Asp Xaa Val Met Thr Gln Xaa Pro Leu Ser Leu Pro Val 15 20 25 Xaa Xaa Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 30 35 Gln Ser Leu Xaa Tyr Ser Asp Gly Asn Ala Tyr Leu His 40 45 50 Trp Phe Leu Gln Lys Pro Gly Gln Ser Pro Xaa Leu Leu 55 60 65 Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp 70 75 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 80 85 90 Lys Ile Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr 95 100 Tyr Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly 105 110 Xaa Gly Thr Xaa Xaa Glu Ile Lys Arg wherein: Xaa at position 2 is Vle or Ile; Xaa at position 7 is Ser or Thr; Xaa at position 14 is Thr or Ser; Xaa at position 15 is Leu or Pro; Xaa at position 30 is Ile or Val; Xaa at position 50 is Arg, Gln, or Lys; Xaa at position 88 is Val or Leu; Xaa at position 105 is Gln or Gly; Xaa at position 108 is Lys or Arg; and Xaa at position 109 is Val or Leu; and (b) a heavy chain comprising a heavy chain variable region comprising the following sequence: (SEQ ID NO:8) 1 5 10 Xaa Val Gln Leu Val Glu Xaa Gly Gly Gly Leu Val Gln 15 20 25 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 30 35 Phe Thr Phe Ser Arg Tyr Ser Met Ser Trp Val Arg Gln 40 45 50 Ala Pro Gly Lys Gly Leu Xaa Leu Val Ala Gln Ile Asn 55 60 65 Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Xaa Val Lys 70 75 Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Xaa Asn Thr 80 85 90 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Xaa Asp Thr 95 100 Ala Val Tyr Tyr Cys Ala Ser Gly Asp Tyr Trp Gly Gln 105 100 Gly Thr Xaa Val Thr Val Ser Ser wherein: Xaa at position 1 is Glu or Gln; Xaa at position 7 is Ser or Leu; Xaa at position 46 is Glu, Val, Asp, or Ser; Xaa at position 63 is Thr or Ser; Xaa at position 75 is Ala, Ser, Val or Thr; Xaa at position 76 is Lys or Arg; Xaa at position 89 is Glu or Asp; and Xaa at position 107 is Leu or Thr and wherein the humanized antibody binds to an abeta peptide.