Patent ID: 8278311

Claim:
A compound of formula (I): or a pharmaceutically acceptable, salt, ester, or amide thereof, wherein p is 1; q is 0; r is 0; and X is O; v and w are single or double bonds; with the proviso that w can be a single or a double bond when p is 1; R 1 is selected from hydrogen, —(C═O)—NH-alkylene(NR 13 R 14 ), —(C═O)—(NR 13 R 14 ), NH 2 , —NH(acyl), —NH(alkyl), —N(alkyl) 2 , —NH-alkylene-heteroaryl, —NH-alkylene(NR 13 R 14 ), —NH(C═O)-alkylene(NR 13 R 14 ), —NH(C═O)aryl, —NR 13 (C═O)NR 13 R 14 , —NHOH, —NHOCH 3 , —O-alkylene(NR 13 R 14 ), alkoxy, alkoxycarbonyl, alkyl, carboxy, cyano, cyanoalkyl, cycloalkyl, fluoroalkyl, fluorocycloalkyl, hydroxyalkyl, and piperazine; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkylthio, alkynyl, amido, aryl, carboxy, cyano, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, fluoroalkoxy, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, formyl, halogen, heteroaryl, heterocycle, hydrogen, hydroxy, hydroxyalkyl, mercapto, nitro, C(O)NR 13 R 14 , NR 11 COalkyl, —NR 13 R 14 , —N(R 13 )SO 2 (R 14 ), —O-aryl, —O-heteroaryl, —S-aryl, and —SO 2 (NR 13 R 14 ); R 2 and R 4 together with the atom they are attached may form a ring, alternatively, any two of R 2 , R 4 , R 6 , and R 8 that are on non-adjacent carbon atoms, may optionally be taken together to form a bridge selected from —CH═CH—, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, or —CH 2 CH 2 CH 2 CH 2 CH 2 —; R 11 is selected from alkoxyalkyl, alkyl, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, hydrogen, and hydroxyalkyl; R 12 is selected from the group consisting of alkoxyalkyl, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, and hydroxyalkyl; R 13 and R 14 are each independently selected from acyl, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylsulfonyl, amido, aryl, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, formyl, heteroaryl, heterocycle, hydrogen, hydroxy, and hydroxyalkyl; A 1 is a group of structure A 2 or A 3 wherein A 2 is and A 3 is selected from wherein G 1 is O, S, S(O), or S(O) 2 ; n is 1,2, or 3; m is 0,1, or 2; wherein each carbon atom of groups A 1 may be optionally substituted with one or more groups selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylsulfonyl, alkylthio, alkynyl, amido, carboxy, cyano, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, fluorine, fluoroalkoxy, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, formyl, hydroxy, hydroxyalkyl, mercapto, and nitro.