Patent ID: 8440681

Claim:
A compound of Formula (1): or a pharmaceutically acceptable salt thereof; wherein R 1a is halo, C 1-6 alkyl, or a halo-substituted C 1-6 alkyl; R 1b is H; R 2 is a C 6-10 carbocyclic, or a 5-10 membered heteroaryl or 5-7 membered heterocyclic ring each having 1-3 heteroatoms selected from N, O and S; each of which is optionally substituted with C 1-6 alkyl, -L-Y, -L-C(O)O 0-1 —(CR 2 ) q —R 8 or -L-C(O)—NRR 8 ; R 3 is H or CO(R 7 ) wherein R 7 is C 1-6 alkyl; R 4 is H; R 5 and R 6 are independently C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl or C 2-6 alkynyl, each of which may be optionally substituted with halo, amino or hydroxyl groups; or R 5 and R 6 are independently halo, nitro, cyano, OR 8 , O(CR 2 ) p —OR 8 , -L-NR(R 8 ), -L-NR(CR 2 ) p OR 8 , -L-NR—(CR 2 ) q —C(O)R 9 , -L-Y, -L-C(O)O 0-1 —(CR 2 ) q —R 8 , -L-C(O)—NRR 8 , -L-C(O)—NR—(CR 2 ) p —NRR 8 , -L-C(O)NR(CR 2 ) p OR 8 , -L-C(O)—(CR 2 ) q —NR—C(O)—R 9 , -L-C(O)NR(CR 2 ) p SR 8 , -L-C(O)NR(CR 2 ) p S(O) 1-2 R 9 , -L-S(O) 2 R 9 , -L-S(O) 2 NRR 8 , -L-S(O) 2 NR(CR 2 ) p NR(R 8 ), -L-S(O) 2 NR(CR 2 ) p OR 8 ; alternatively, two adjacent R 5 groups together with the carbon atoms they are attached to may form a 9-14 membered ring; R 8 and R 9 are independently (CR 2 ) 9 Y or C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl or C 2-6 alkynyl, each of which may be optionally substituted with halo, amino or hydroxyl; or R 8 is H; each R is H or C 1-6 alkyl; Y is a C 3-12 carbocyclic ring, C 6-10 aryl or a 5-10 membered heteroaryl or heterocyclic ring, each having 1-4 heteroatoms selected from N, O and S; wherein Y is optionally substituted with 1-3 C 1-6 alkyl; L is (CR 2 ) 1-4 or a bond; m is 2-4; p is 1-4; and n and q are independently 0-4.