Patent ID: 6861060

Claim:
A formulation for application to a mucosal tissue, the formulation comprising: (a) a biologically active agent wherein said biologically active agent is an antibiotic selected from the group consisting of 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-,alpha,-L-ribo-hexopyranosyl)oxy]-11 12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]], [4-S-(4-alpha,4a-alpha,5a-alpha,6-beta,12a-alpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6-11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11 dioxo-2-naphthacenecarboxamide, and D-threo-N-dichloracetyl-1-p-nitrophenyl-2-amino-1,3-propanediol; D-)-(threo-2-dichloroacetamido-1-p-nitrophenyl-1,3-propanediol; an antiviral agent selected from the group consisting of azothymidine, 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl 1}-6 H-purin-6-one, dideoxyuridine, and Cis-1-Acetyl-4-[4-[[2-(2,4-dichloro-phenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxo-1an-4-yl]methoxy]-phenyl]piperazine; an antifungal agent selected from the group consisting of Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, 1H-1,2,4-Triazole-1-ethanol, alpha(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-2-(2,4-Difluorophenyl)-1,3.bis(1H-1,2,4-triazol-1-yl)-2-propanol alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol, 1-[2,4-dichloro-beta-[(2,4-dichlorobenzyl)oxy [phenethyl]imidazole, Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester, Polyene antibiotic produced by Streptomycetes nodosus M4575, and 2-Deoxy-4-O-(2,6-diamine-2,6-dideoxy-alpha-D-glucopyranosyl)-D-strePtamine; a disinfectant selected from the group consisting of N N″-Bis(4-chlorophenyl)-3,12-diimino-2,4,11 13-tetraazatetradecanediimidamide; 1,1′-hexamethylenebis[5-(p-chlorophenyl)biguanide], chlorhexidine salts, 5-Chloro-2-(2,4-dichlorophenoxy)phenol, centrimide, and 1-Hexadecylpyridinium chloride; an anti-inflammatory agent is selected from the group consisting of non-steroidals and steroidals; a local anesthetic selected from the group consisting of omega-diethylamino-2,6-dimethylacetanilide, trimecaine, and 4-aminobenzoic acid ethyl ester; an essential oil selected from the group consisting of menthol, vanillin, peppermint oil, clove oil, eucalyptus oil and lavender oil; and (b) a lipid carrier, said lipid carrier having the property of adhesion capacity to mucosal tissue, said lipid carrier including at least one lipid selected from the group of amphiphilic phospholipids consisting of yolk lecithin, Soya lecithin phosphatidylglycerol and analogs thereof said lipid being characterized as mixed micelles dispersed in an aqueous medium, and said lipid and said biologically active agent being present in a ratio of from about 10:1 to about 1:10.