Patent ID: 6867294

Claim:
An oligomeric compound of the formula: 5′-(Nu 1 —L 1 ) n —Y—(L 2 -Nu 2 ) p —3′ wherein: each Nu 1 and Nu 2 , independently, has the formula: wherein Bx is a heterocyclic base moiety; Lx is hydrogen, a protecting group or a substituent group; one of R 12 , R 13 and R 14 is hydroxyl, a protected hydroxyl, a covalent attachment to a solid support, a nucleoside, an oligonucleoside, a nucleotide, an oligonucleotide, a conjugate group or an optionally protected substituent group; another of R 12 , R 13 and R 14 is hydrogen, hydroxyl, a protected hydroxyl or an optionally protected substituent group; the remaining of R 12 , R 13 and R 14 , of Nu 1 , is L 1 ; the remaining of R 12 , R 13 and R 14 , of Nu 2 , is L 2 ; each L 1 and each L 2 is, independently, a phosphodiester, phosphorodithioate; chiral Sp phosphorothioate; phosphoramidate; thiophosphoramidate; phosphonate; methylene phosphonate; phosphotriesters; thionoalkylphosphonate; thionoalkylphosphotriester; boranophosphate; boranothiophosphate; thiodiester; thionocarbamate; siloxane; carbamate; sulfamate; morpholino sulfamide; sulfonamide; sulfide; sulfonate; N,N′-dimethylhvdrazine; thioformacetal; formacetal; thioketal; ketal; amine (—NH—CH 2 —CH 2 —); hydroxylamine; hydroxylimine; hydrazinyl; amide (—CH 2 —N(JJ)—C(O)—) and (—CH 2 —C(O)—N(JJ)—); oxime (—CH 2 —O—N═CH—); or alkylphosphorus (—C(JJ) 2 —P(═O)(OJJ)—C(JJ) 2 —C(JJ) 2 —) internucleoside linkage, wherein each JJ is, independently, hydrogen or C 1 to C 10 alkyl wherein at least one of L 1 and L 2 is other than phosphodiester; Y has the formula: wherein; each Rp is a chiral Rp phosphorothioate internucleotide linkage; and each n, m and p is, independently, from 1 to 100; where the sum of n, m and p is from 3 to about 200; wherein the oligomeric compound comprises from 5 to about 50 nucleosides.