Patent ID: 8569294

Claim:
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutically acceptable salt thereof: wherein each symbol is defined as below: R 4 represents a group represented by the following formula (II): A 14 -A 13 -A 12- (II) wherein A 14 represents hydrogen atom, a C 1 -C 6 alkyl group which may be substituted, a C 2 -C 6 alkenyl group which may be substituted, a C 2 -C 6 alkynyl group which may be substituted, a C 3 -C 7 cycloalkyl group which may be substituted, a C 3 -C 7 cycloalkenyl group which may be substituted, or a heterocyclic group which may be substituted; A 13 represents bond, or oxygen atom; A 12 represents bond, or a C 1 -C 3 methylene group, and A 14 and A 13 may combine to each other to form a 5 to 7 membered heterocyclic ring; X represents oxygen atom; R 5 represents a hydrogen atom, a C 1 -C 6 alkyl group which may be substituted, or a group represented by the following formula (IV): wherein n represents 0 or integer of 1 to 3, A represents a C 6 -C 10 aryl group, R 7 may be the same or different and represents a halogen atom, or a group represented by the following formula (IV-a): C 4 —C 3 —C 2 —C 1 — (IV-a) wherein C 4 represents hydrogen atom (except when all of C 3 , C 2 , and C 1 represent bond), a C 1 -C 6 alkyl group which may be substituted, a C 6 -C 10 aryl group which may be substituted, a heterocyclic group which may be substituted, C 3 represents bond, or oxygen atom, C 2 represents bond, or C═O, C 1 represents bond; s represents 0 or an integer of 1 to 5, R 6 may be the same or different and represents a halogen atom, nitro group, cyano group, or a group represented by the following formula (V): B 14 —B 13 —B 12 —B 11 — (V) wherein B 14 represents hydrogen atom(except when all of B 13 , B 12 , and B 11 represent bond), a C 1 -C 6 alkyl group which may be substituted, a heterocyclic group which may be substituted, B 13 represents bond, B 12 represents bond, B 11 represents bond; p represents an integer of 0 to 6; Z represents nitrogen atom, C—H or C—R 20 ; R 20 may be the same or different and represents a halogen atom, or a group represented by the following formula (VI): D 4 -D 3 -D 2 -D 1 - (VI) wherein D 4 represents a C 1 -C 6 alkyl group which may be substituted, D 3 represents bond, or oxygen atom, D 2 represents bond, D 1 represents bond, q represents 0 or an integer of 1 to 3; R 2 represents hydrogen atom, a halogen atom or a C 1 -C 6 alkyl group which may be ubstituted; R 3 represents a C 1 -C 12 alkyl group; any one or more of R 5 and R 6 , R 5 and R 4 , R 6 and R 4 , and R 6 and R 6 may combine to each other to form a fused, carbocyclic or heterocyclic ring, together with the ring which contains X, and R 5 , R 4 and R 6 bind to; and each symbol satisfies the following proviso (1): (1) when R 4 is a hydrogen atom, at least one of R 5 and R 6 , and R 6 and R 6 combine to each other to form a fused carbocyclic or heterocyclic ring, together with the ring which contains X, and R 5 , R 4 and R 6 bind to.