Patent ID: 7635680

Claim:
A method of attenuating ischemia-reperfusion injury (IRI), said method comprising administering to a patient in need thereof a phosphatidylserine (PS) binding agent wherein the PS binding agent binds with high affinity to PS on cell surfaces, and wherein the PS binding agent is an isolated annexin at least 95% identical to a protein selected from the group consisting of SEQ ID NO: 6, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 19, SEQ ID NO: 23, SEQ ID NO: 3-linker-SEQ ID NO: 3, SEQ ID NO: 12-linker-SEQ ID NO: 12, and SEQ ID NO: 15-linker-SEQ ID NO: 15, SEQ ID NO: 3-linker-SEQ ID NO: 12, SEQ ID NO: 3-linker-SEQ ID NO: 15, SEQ ID NO: 12-linker-SEQ ID NO: 15, SEQ ID NO: 12-linker-SEQ ID NO: 3, SEQ ID NO: 15-linker-SEQ ID NO: 3 and SEQ ID NO: 15-linker-SEQ ID NO: 12, wherein the linker is at least one glycine-serine sequence, and whereby said administering attenuates IRI.