Patent ID: 6852711

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof wherein R 1 is H, a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R 2 is H, a straight or branched alkyl of 1-5 carbons; R 3 is H, (CR′ 2 ) n OR, (CR′ 2 ) n N(R) 2 , (CR′ 2 ) n NR′COR, (CR′ 2 ) n CO 2 R, (CR′ 2 ) n OCOR, (CR′ 2 ) n CON(R) 2 , (CR′ 2 ) n OCON(R) 2 , (CR′ 2 ) n R, (CR′ 2 ) n NR′CON(R) 2 , (CR′ 2 ) n NR′CO 2 R, (CR′ 2 ) n OSO 2 N(R) 2 , (CR′ 2 ) n NR′SO 2 OR, (CR′ 2 ) n NR′SO 2 N(R) 2 , (CR′ 2 ) n OSO 2 R, (CR′ 2 ) n NR′SO 2 R, (CR′ 2 ) n SO p R, (CR′ 2 ) n NR′CSN(R) 2 , (CR′ 2 ) n NR′C(NR′)N(R) 2 , (CR′ 2 ) n SO 2 N(R) 2 , (CR′ 2 ) n C(NR′)N(R) 2 , (CR′ 2 ) n COR, O(CR′ 2 ) m OR, NR(CR′ 2 ) m OR, F, Cl, Br, CF 3 , CN, or ═O; R 4 , R 5 , and R 6 are independently H, a straight or branched alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons, (CR′ 2 ) n OR, (CR′ 2 ) n N(R) 2 , F, Cl, Br, CN, CF 3 , ═O, (CR′ 2 ) p NR′COR, (CR′ 2 ) p SO p R, (CR′ 2 ) p R, (CR′ 2 ) p OCOR, O(CR′ 2 ) m OR, NR(CR′ 2 ) m OR, (CR′ 2 ) p NR′CON(R) 2 , (CR′ 2 ) p OCON(R) 2 , (CR′ 2 ) p NR′CO 2 R, (CR′ 2 ) p COR, (CR′ 2 ) p CO 2 R, (CR′ 2 ) p CON(R) 2 , (CR′ 2 ) p NR′SO 2 R, (CR′ 2 ) p SO 2 N(R) 2 , (CR′ 2 ) p NR′SO 2 OR, (CR′ 2 ) p OSO 2 N(R) 2 , (CR′ 2 ) p NR′SO 2 N(R) 2 , (CR′ 2 ) p C(NR′)N(R) 2 , (CR′ 2 ) p NR′C(NR′)N(R) 2 , (CR′ 2 ) p Het; any two of R 1 -R 3 or R 4 -R 6 may together form a ring of 5-6 total atoms which may contain 0-3 heteroatoms; n is an integer of from 0 to 3; m is an integer of from 2 to 4; p is an integer from 0 to 2; R 7 is a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R is independently H, a straight or branched alkyl of 1-4 carbons, (CH 2 ) n Ph, or a (CH 2 ) n heterocycle of 5-6 atoms containing 1-2 heteroatoms and wherein the (R) 2 in N(R) 2 may form a heterocycle containing the nitrogen, all optionally substituted by F, Cl, Br, OR′, CN, CO 2 R′, N(R′) 2 , NR′COR′, CF 3 , or ═O; R′ is independently H, a straight or branched alkyl of 1-4 carbons, or phenyl; R″ is independently H, a straight or branched alkyl of 1-4 carbons, F, Cl, Br, OR′, or N(R′) 2 ; Ar 1 is Het; wherein Het is a heterocycle of from 5-6 atoms having 1-4 heteroatoms selected from pyrrole, thiophene, oxazole, isoxazole, thiazole, pyrazole, 1,2,3-triazole, 1,2,4-triazole, tetrazole, pyridine, pyridazine, pyrimidine, or pyrazine, or a fused heterocycle of from 9-10 atoms having from 1-3 heteroatoms selected from; indole, indoline, benzothiophene, benzthiazole, benzoxazole, quinoline, isoquinoline, cinnoline, quinazoline and quinoxaline; and Ar 2 is phenyl.