Patent ID: 8158149

Claim:
A controlled release pharmaceutical formulation, comprising: an effective amount of threo-3-(3,4-dihydroxyphenyl)serine, a derivative thereof, or a pharmaceutically-acceptable salt thereof, in an extended release form adapted for oral delivery of the active agent such that the active agent is released over a period of time of at least 8 hours by dissolution controlled release, diffusion controlled release, or dissolution and diffusion controlled release; and an effective amount of threo-3-(3,4-dihydroxyphenyl)serine, a derivative thereof, or a pharmaceutically-acceptable salt thereof, in an immediate release form; wherein the formulation comprises 45-85% by weight of total active drug of threo-3-(3,4-dihydroxyphenyl)serine or a derivative or pharmaceutically acceptable salt thereof in extended release form and 15-55% by weight of total active drug of threo-3-(3,4-dihydroxyphenyl)serine or derivative or pharmaceutically acceptable salt thereof in immediate release form.