Patent ID: 7238694

Claim:
A compound having a structural formula I: wherein: X is a linker group selected from one or a combination of two to three of the following groups: (a) (C 1 -C 6 )alkylene, (b) (C 3 -C 8 )cycloalkylene, (c) arylene, (d) bivalent heterocyclic group containing 1 to 3 heteroatoms, (e) —C(═O)—, (f) —C(═N—O—R 11 )—, wherein R 11 represents hydrogen, (C 1 -C 6 )alkyl, or substituted (C 1 -C 6 alkyl), (g) —C═N—, (h) —O—, (i) —S(O) n —, wherein n is number between 0 and 2, and (j) —N(R 12 )—, wherein R 12 represents hydrogen, (C 1 -C 6 )alkyl, or substituted (C 1 -C 6 alkyl), wherein the carbon or nitrogen atoms of the linker group are optionally substituted by 1 to 3 substituents selected from (C 1 -C 6 )alkyl, substituted (C 1 -C 6 )alkyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, hydroxyl, or (C 1 -C 6 )alkoxy; R i is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, substituted (C 3 -C 6 )cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; R ii is hydrogen, halogen, amino, nitro or methyl group; Y is C—H, C—F, or N; Z is C—H, C—F, C—CN, C—CF 3 , C—Cl, C—Me, C—OMe, C—OCH 2 F, C—OCHF 2 , or N; and R is hydrogen, or acetyl, or a pharmaceutically acceptable salt of the structural formula I.