Patent ID: 7179910

Claim:
A method of synthesizing a compound of Formula (I): wherein: R 1 is selected from the group consisting of hydrogen, halo, alkyl, haloalkoxy, cycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, —(CO)R 8 , —NR 9 R 10 , —(CHR 3 ) i R 11 and —C(O)NR 12 R 13 ; R 2 is selected from the group consisting of hydrogen, halo, alkyl, trihalomethyl, hydroxy, alkoxy, cyano, —NR 9 R 10 , —NR 9 C(O)R 10 , —C(O)R 8 , aryl, heteroaryl, —S(O) 2 NR 9 R 10 and —SO 2 R 14 wherein R 14 is alkyl, aryl, aralkyl, heteroaryl and heteroaralkyl; R 3 , R 4 and R 5 are independently hydrogen or alkyl; Z is aryl, heteroaryl, heterocycle, or —NR 15 R 16 wherein R 15 and R 16 are independently hydrogen or alkyl; or R 15 and R 16 together with the nitrogen atom to which they are attached form a heterocycloamino group; R 6 is selected from the group consisting of hydrogen and alkyl; R 7 is selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, and —C(O)R 17 as defined below; R 8 is selected from the group consisting of hydrogen, hydroxy, alkoxy and aryloxy; R 9 and R 10 are independently selected from the group consisting of hydrogen, alkyl, cyanoalkyl, cycloalkyl, aryl and heteroaryl; or R 9 and R 10 combine to form a heterocycloamino group; R 11 is selected from the group consisting of hydroxy, —C(O)R 8 , —NR 9 R 10 and —C(O)NR 9 R 10 wherein R 8 , R 9 and R 10 are as defined above; R 12 and R 13 are independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, and aryl; or R 12 and R 13 together with the nitrogen atom to which they are attached form a heterocycloamino; and R 17 is selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl comprising reacting a compound of Formula (II) with a compound of Formula (III) H 2 N—CH(R 3 )—CR 4 (OH)—CH(R 5 )Z in the presence of an organic solvent and a coupling agent, to form compound (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 7 and Z are as defined above.