Patent ID: 7763732

Claim:
An indole having the general Formula I wherein A represents a 5-membered aromatic heterocyclic oxadiazole or thiadiazole ring, wherein X 1 , X 2 and X 3 are independently selected from N, O, and S; Y is CH 2 , O, S or SO 2 ; R 1 is (C 1-4 )alkyl, (C 1-4 )alkyloxy, CN or halogen; R 2 is H or (C 1-4 )alkyl; or R 2 together with R 3 and the carbon and nitrogen atoms to which they are bonded form pyrrolidine; R 3 is H, (C 1-6 )alkyl or (C 3-7 )cycloalkyl, the alkyl groups being optionally substituted with OH, (C 1-4 )alkyloxy, (C 1-4 )alkylthio, (C 1-4 )alkylsulfonyl, CO—NR 5 R 6 , CO—OR 7 , CN or halogen; R 4 is CO—NR 5 R 6 , CO—OR S , SO 2 —R 8 , SO 2 —NR 9 R 10 , or CO—R 11 ; or R 4 is (C 1-3 )alkyl, substituted with CO—NR 5 R 6 , CO—OR 7 , SO 2 —R 8 , SO 2 —NR 9 R 10 , NH—CO—R 11 , NH—SO 2 —R 12 , or two OH groups; and optionally further substituted with OH; or R 4 together with R 3 and the N to which they are bonded form a 4-8 membered ring optionally containing a further heteroatom selected from O, S and SO 2 , the ring being substituted with CO—NR 13 R 14 , CO—OR 7 , SO 2 —R 8 , SO 2 —NR 9 R 10 , NH—CO—R 11 or NH—SO 2 —R 12 ; or the ring being substituted with (C 1-3 )alkyl, substituted with NH—CO—R 11 or NH—SO 2 —R 12 ; R 5 , when present, is H or (C 1-4 )alkyl, optionally substituted with OH, (C 1-4 )alkyloxy or CONR 7 R 8 ; R 6 , when present, is H or (C 1-4 )alkyl; or R 6 together with R 5 and the N to which they are bonded form a 4-8 membered ring optionally containing a further heteroatom selected from O, S and SO 2 , the ring being optionally substituted with OH; R 7 , when present, is H or (C 1-4 )alkyl; R 8 , when present, is (C 1-4 )alkyl or (C 3-7 )cycloalkyl, optionally substituted with OH or (C 1-4 )alkyloxy; R 9 , when present, is H or (C 1-4 )alkyl, optionally substituted with OH or (C 1-4 )alkyloxy; R 10 , when present, is H or (C 1-4 )alkyl; R 11 , when present, is H or (C 1-4 )alkyl, optionally substituted with OH or (C 1-4 )alkyloxy; R 12 , when present, is (C 1-4 )alkyl, optionally substituted with OH or (C 1-4 )alkyloxy; R 13 , when present, is H or (C 1-4 )alkyl, optionally substituted with OH, (C 1-4 )alkyloxy or CONR 7 R 8 ; R 14 , when present, is H or (C 1-4 )alkyl; or R 14 together with the C atom to which the CO—NR 13 R 14 group is bonded form a 5- or 6-membered spiro-ring; with the proviso that when Y is SO 2 , R 4 may further represent H, (C 1-6 )alkyl or (C 3-7 )cycloalkyl, the alkyl groups being optionally substituted with OH, (C 1-4 )alkyloxy, (C 1-4 )alkylthio, (C 1-4 )alkylsulfonyl, CN or halogen; or R 3 together with R 4 and the N to which they are bonded may form a 4-8 membered ring optionally containing a further heteroatom selected from O, S and SO 2 the ring being optionally substituted with OH; or a pharmaceutically acceptable salt thereof.