Patent ID: 7438930

Claim:
An oral controlled release formulation which provides a rapid onset of therapeutic effect and a rapid drop in plasma concentration after a prolonged period of therapeutic effect, comprising a plurality of matrix particulates comprising: a first portion of an effective dose of methylphenidate or a pharmaceutically acceptable salt thereof incorporated in a controlled release matrix, a hydrophobic material comprising an acrylic polymer applied over the controlled release matrix in an amount sufficient to retard the release of the first portion of methylphenidate or a pharmaceutically acceptable salt thereof from the controlled release matrix; an enteric coating applied over the hydrophobic material in an amount sufficient to substantially delay the release of said drug from said substrate until after said formulation passes through the stomach, wherein said enteric coating is derived from an aqueous dispersion comprising an acrylic/methacrylic copolymer, a plasticizer and a glidant; and a topcoat comprising a second portion of the methylphenidate or a pharmaceutically acceptable salt thereof in immediate release form; wherein the formulation provides a time to mean maximum plasma concentration of methylphenidate at about 0.5 to about 4 hours after oral administration.