Patent ID: 7378427

Claim:
A method of synthesizing a compound of formula (I): wherein: R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9 , R 10 , R 13 and R 14 are, independently, hydrogen, C 1 -C 12 alkyl, halogen, or C 6 -C 10 aryl; R 5 is C 1 -C 12 alkyl or C 6 -C 10 aryl; and R 11 and R 12 are, independently, hydrogen, C 1 -C 12 alkyl, or —O—PG 1 where PG 1 is hydrogen, a phenol protecting group, sulfamate, or alkylcarbonate; comprising: providing chiral, non-racemic compound of formula (IIa): and reacting said compound of formula (IIa) with an alkylphoshine or arylphosphine and a diarylazodicarboxylate or dialkylazodicarboxylate in an aprotic solvent to form the compound of formula (I), wherein said providing chiral, non-racemic compound of formula (IIa) optionally comprises: (a) providing chiral, non-racemic compound of formula (II) wherein PG is an amino protecting group; and (b) removing said amino protecting group thereby forming the compound of formula (IIa).