Patent ID: 7115393

Claim:
An isolated polynucleotide comprising, a polynucleotide sequence coding without interruption for a human MCR-1C (melanocortin receptor 1C), or the complete complement to said polynucleotide sequence, said MCR-1C having 84% or more amino acid sequence identity along its entire length to the sequence consisting of amino acids 1–316 of SEQ ID NO 2, and 90% or more amino acid sequence identity along its entire length to the sequence consisting of amino acids 317–398 of SEQ ID NO 2, and which has ligand-binding activity, G-protein binding activity, or cAMP production activity, wherein said polynucleotide sequence coding for human MCR-1C hybridizes under high stringency conditions to the complete complement of SEQ ID NO: 1 from nucleotide position 342–1535, and the conditions comprise overnight incubation in 5X SSC, 0.5% SDS, 100 μ/ml denatured salmon sperm DNA and 50% formamide, at 42° C. followed by washing in 0.1% SSC and 0.1% SDS for 30 min at 65° C.