Patent ID: 8658765

Claim:
A non-natural, monomeric, soluble, mammalian MHC class I chain-related (MIC) molecule comprising an α1-α2 platform domain attached to a targeting motif, wherein the α1-α2 platform domain is at least 80% identical to a native α1-α2 platform domain of a human MICA or MICB protein, and wherein the α1-α2 platform domain binds an NKG2D receptor, and wherein the targeting motif comprises a MIC α3 domain and a heterologous peptide, wherein the heterologous peptide is inserted into the MIC α3 domain at a non-carboxy-terminal site, and wherein the heterologous peptide directs the binding of the targeting motif to a target molecule on a target cell, thereby delivering the attached α1-α2 platform domain to the target cell.