Patent ID: 8426431

Claim:
A method of treating or ameliorating manic depression or anxiety in a mammal, comprising administering to a mammal in need of such treatment an effective amount of a compound having the Formula II: or a pharmaceutically acceptable salt or prodrug thereof, wherein: R 1 , R 2 , R 3 and R 4 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R 5 , R 6 and R 7 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl, or R 5 , is defined as above, and R 6 and R 7 together with the nitrogen atom to which they are attached form a heterocycle; A 1 is aryl, heteroaryl, saturated or partially unsaturated carbocycle or saturated or partially unsaturated heterocycle, any of which is optionally substituted; A 2 is aryl, which is optionally substituted; X is one of O, S, NR 8 , CH 2 , C(O), NR 8 C(O), C(O)NR 8 , SO, SO 2 or a covalent bond; where R 8 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; and n is 0, 1, 2 or 3.