Patent ID: 6900186

Claim:
A method for ameliorating the effects of a proliferative and/or inflammatory skin disorder in a mammal, said method comprising contacting the proliferating and/or inflamed skin with an effective amount of a nucleic acid molecule selected from the group consisting of 5′-UCCGGAGCCAGACUU-3′ (SEQ ID NO:12); 5′-CACAGUUGCUGCAAG-3′ (SEQ ID NO:13); 5′-UCUCCGCUUCCUUUC-3′ (SEQ ID NO:14); 5′-AGCCCCCACAGCGAG-3′ (SEQ ID NO:15); 5′-GCCULGGAGAUGAGC-3′ (SEQ ID NO:16); 5′-UAACAGAGGUCAGCA-3′ (SEQ ID NO:17); 5′-GGAUCAGGGACCAGU-3′ (SEQ ID NO:18); 5′-CGGCAAGCUACACAG-5′ (SEQ ID NO:19); 5′-GGCAGGCAGGCACAC-3′ (SEQ ID NO:20) or chemical modification of any one of said nucleic acid molecules, wherein said modification produces a modified nucleic acid molecule having a length and nucleotide sequence which is the same as the nucleic acid molecule prior to modification, and wherein the nucleic acid molecule or modified nucleic acid molecule is capable of reducing the level of IGF-I receptor in said mammal.