Patent ID: 7012064

Claim:
A method of treating an inflammatory or immune disorder in a subject while reducing the toxicity associated with the administration of cyclosporin A, comprising systemically administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, in combination with a pharmaceutically acceptable carrier or excipient: wherein A is: X is absent, —C 1 –C 6 alkyl-, or —C 3 –C 6 cycloalkyl Y is selected from the group consisting of: (i) C(O)—O—R 1 , where R 1 is hydrogen, C 1 –C 6 alkyl, optionally substituted with halogen, heterocyclic, aryl, C 1 –C 6 -alkoxy, C 1 –C 6 alkylthio, halogen-substituted C 1 –C 6 alkoxy, or halogen-substituted C 1 –C 6 alkylthio; (ii) C(O)—S—R 1 , where R 1 is as previously defined; (iii) C(O)—OCH 2 —OC(O)R 2 , where R 2 is C 1 –C 6 alkyl, optionally substituted with halogen, C 1 –C 6 alkoxy, C 1 –C 6 alkylthio, heterocyclic or aryl; (iv) C(S)—O—R 1 , where R 1 is as previously defined, and (v) C(S)—S—R 1 , where R 1 is as previously defined; B is -αAbu-, -Val-, -Thr- or -Nva-; and U is -(D)Ala-, -(D)Ser-, —[O-(2-hydroxyethyl)(D)Ser]-, —[O-acyl(D)Ser]- or —[O-(2-acyloxyethyl)(D)Ser]-.