Patent ID: 8193236

Claim:
A compound of formula (I) wherein R a is hydrogen or C 1-6 alkyl optionally substituted by OH, halogen, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , C 1-6 alkoxy, C 3-8 cycloalkyl or heterocyclic residue; R b is hydrogen; halogen; CN; C 1-6 alkyl optionally substituted with OH, halogen, C 1-6 alkoxy, NH 2 , NHC 1-6 alkyl, or N(C 1-6 alkyl) 2 ; optionally substituted C 1-6 alkoxy; or optionally substituted C 1-6 alkoxy-chain; wherein said C 1-6 alkoxy and said C 1-6 alkoxy-chain are optionally substituted with OH, halogen, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , C 1-6 alkoxy, C 3-8 cycloalkyl or heterocyclic residue; R c is hydrogen; halogen; CN; optionally substituted C 1-6 alkyl; optionally substituted C 1-6 alkoxy; wherein C 1-6 alkyl and C 1-6 alkoxy are optionally substituted with OH, halogen, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , C 1-6 alkoxy, C 3-8 cycloalkyl or heterocyclic residue; each of R d and R e independently, is hydrogen; halogen; CN; optionally substituted C 1-6 alkyl; wherein C 1-6 alkyl is optionally substituted with OH, halogen, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , C 1-6 alkoxy, C 3-8 cycloalkyl or heterocyclic residue; wherein R is a radical of formula (a), (b), (c), (d), or (f): wherein either each of R 1 ,R 1a ,R 1b ,R 1c ,R 1d ,R 1e ,R 2 , R 2a ,R 2b ,R 2c ,R 2d , and R 2e independently, is hydrogen; C 1-6 alkyl optionally interrupted by an oxygen atom and optionally substituted by OH, C 1-6 alkoxy, NH 2 , NHC 1-4 alkyl, N(C 1-4 alkyl) 2 ,C 3-8 cycloalkyl or heterocylic residue; C 3-8 cycloalkyl; or haloC 1-6 alkyl; or R 1 and R 2 ,R 1a and R 2a ,R 1b and R 2b ,R 1c and R 2c , R 1d and R 2d , or R 1e and R 2e , respectively, form together with the nitrogen atom to which they are bound a heterocyclic residue; each of R 3 ,R 3a ,R 3b ,R 3c ,R 3d , and R 3e independently, is hydrogen; halogen; CN; NO 2 ; C 1-6 alkyl; haloC 1-6 alkyl; R′ is hydrogen; C 1-6 alkyl; halo-C 1-6 alkyl; CH 2 -C 1-5 alkyl, the C 1-5 alkyl being optionally substituted by OH, C 1-6 alkoxy, NH 2 , NHC 1-6 alkyl, or N(C 1-6 alkyl) 2 ; or a pharmaceutically acceptable salt thereof.