Patent ID: 7629373

Claim:
The compound of the Formula II: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein a is independently 0 or 1; b is independently 0 or 1; m is independently 0, 1, or 2; R 1 is selected from: 1) C 1 -C 10 alkyl, and 2) C 3 -C 8 cycloalkyl; R 2 is selected from: 1) H, 2) C 1 -C 4 alkyl, 3) halo, and 4) OH, said alkyl optionally substituted with one, two or three substituents selected from R 6 ; R 3 is selected from chloro, fluoro and bromo; R 5 is F; R 6 independently is: 1) (C═O) a O b C 1 -C 10 alkyl, 2) (C═O) a O b aryl, 3) C 2 -C 10 alkenyl, 4) C 2 -C 10 alkynyl, 5) (C═O) a O b heterocyclyl, 6) CO 2 H, 7) halo, 8) CN, 9) OH, 10) O b C 1 -C 6 perfluoroalkyl, 11) O a (C═O) b NR 8 R 9 , 12) S(O) m R a , 13) S(O) 2 NR 8 R 9 , 14) oxo, 15) CHO, 16) (N═O)R 8 R 9 , or 17) (C═O) a O b C 3 -C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 7 ; R 7 is independently selected from: 1) (C═O) a O b (C 1 -C 10 )alkyl, wherein r and s are independently 0 or 1, 2) O b (C 1 -C 3 )perfluoroalkyl, wherein r is 0 or 1, 3) oxo, 4) OH, 5) halo, 6) CN, 7) (C 2 -C 10 )alkenyl, 8) (C 2 -C 10 )alkynyl, 9) (C═O) a O b (C 3 -C 6 )cycloalkyl, 10) (C═O) a O b (C 0 -C 6 )alkylene-aryl, 11) (C═O) a O b (C 0 -C 6 )alkylene-heterocyclyl, 12) (C═O) a O b (C 0 -C 6 )alkylene-N(R b ) 2 , 13) C(O)R a , 14) (C 0 -C 6 )alkylene-CO 2 R a , 15) C(O)H, 16) (C 0 -C 6 )alkylene-CO 2 H, and 17) C(O)N(R b ) 2 , 18) S(O) m R a , and 19) S(O) 2 NR 8 R 9 ; said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b ) 2 ; or two R 7 s, attached to the same carbon atom are combined to form —(CH 2 ) u — wherein u is 3 to 6 and one or two of the carbon atoms is optionally replaced by a moiety selected from O, S(O) m , —N(R a )C(O)—, —N(R b )— and —N(COR a )—; R 8 and R 9 are independently selected from: 1) H, 2) (C═O)O b C 1 -C 10 alkyl, 3) (C═O)O b C 3 -C 8 cycloalkyl, 4) (C═O)O b aryl, 5) (C═O)O b heterocyclyl, 6) C 1 -C 10 alkyl, 7) aryl, 8) C 2 -C 10 alkenyl, 9) C 2 -C 10 alkynyl, 10) heterocyclyl, 11) C 3 -C 8 cycloalkyl, 12) SO 2 R a , and 13) (C═O)NR b 2 , or R 8 and R 9 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 5-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S; R a is independently selected from: (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, and heterocyclyl; and R b is independently selected from: H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O)OC 1 -C 6 alkyl, (C═O)C 1 -C 6 alkyl or S(O) 2 R a .