Patent ID: 7229620

Claim:
A method for radiolabeling a chelator-conjugated antibody or antibody fragment with 90 Y for administration to a patient comprising: (i) mixing the chelator-conjugated antibody or antibody fragment with a solution comprising 90 Y or a salt thereof, and (ii) incubating the mixture for a sufficient amount of time under amiable conditions such that a 90 Y-labeled antibody or antibody fragment is produced having sufficient radioincorporation, immunoreactivity of at least 50%, and a specific activity of at least about 5 mCi/mg, such that the 90 Y-labeled antibody or antibody fragment may be administered directly to the patient without further purification of the 90 Y-labeled radiolabeled antibody or antibody fragment from unincorporated 90 Y; wherein said chelator is a bifunctional chelator selected from the group consisting of MX-DTPA, phenyl-DTPA, benzyl-DTPA, CHX-DTPA, DOTA and derivatives thereof.