Patent ID: 7214663

Claim:
A compound comprising: (1) a therapeutic agent capable of entering a target cell, (2) an oligopeptide of the formula AA 3 -AA 2 -AA 1 wherein the oligopeptide is selected from the group consisting of: Leu-Ala-GIy (SEQ ID NO: 10), and Leu-Tyr-Leu (SEQ ID NO: 13); (3) a stabilizing group; (4) optionally, a linker group not cleavable by TOP, wherein the oligopeptide is directly linked to the stabilizing group at a first attachment site of the oligopeptide and the oligopeptide is directly linked to the therapeutic agent or indirectly linked through the linker group to the therapeutic agent at a second attachment site of the oligopeptide, wherein the stabilizing group hinders cleavage of the oligopeptide by enzymes present in whole blood, and wherein the compound is cleavable by TOP.