Patent ID: 6872722

Claim:
A therapeutic method comprising administering to a mammal in need of treatment or prevention of tissue damage resulting from ischemia an effective amount of a compound of formula I or a prodrug of said compound, or a pharmaceutically acceptable salt of said compound or said prodrug, wherein: R 1 and R 2 are each independently hydrogen or methyl; X and Y together are CH 2 —CH(OH)—Ar or CH 2 —C(O)—Ar, or X is a covalent bond, NR 3 or CHR 4 , wherein, R 3 is (C 1 -C 3 )alkyl or a phenyl that is optionally substituted with one or more substituents selected from OH, F, Cl, Br, I, CN, CF 3 , (C 1 -C 6 )alkyl, O—(C 1 -C 6 )alkyl, S(O) n —(C 1 -C 8 )alkyl and SO 2 —NR 5 R 6 , and R 4 is hydrogen or methyl, and Y is a phenyl or naphthyl ring optionally substituted with one or more substituents selected from Ar, OH, F, Cl, Br, I, CN, CF 3 , (C 1 -C 6 )alkyl, O—(C 1 -C 6 )alkyl, S(O) n —(C 1 -C 6 )alkyl and SO 2 —NR 5 R 6 ; Ar is a phenyl or naphthyl ring optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, CF 3 , (C 1 -C 6 )alkyl, O—(C 1 -C 6 )alkyl, S(O) n —(C 1 -C 6 )alkyl and SO 2 —NR 5 R 6 ; n is independently for each occurrence 0, 1 or 2; R 5 is independently for each occurrence H, (C 1 -C 6 )alkyl, phenyl or naphthyl; and R 6 is independently for each occurrence (C 1 -C 6 )alkyl, phenyl or naphthyl.