Patent ID: 8765738

Claim:
A compound having a structural formula: wherein R a is selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, OR e , N(R e ) 2 , and SR e ; alternatively, either R a and R 1 or NR e and R 1 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic or heterocyclic ring; R b is selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, OR e , N(R e ) 2 , and SR e , alternatively, either R b and R 6 or NR e and R 6 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic ring or a five or six-membered aliphatic carbocyclic or heterocyclic ring; R c is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(═O)R e , or R c and R d are taken together to form a five, six, or seven-membered aliphatic ring, optionally containing an oxygen atom; R d is selected from the group consisting of hydrogen, C 1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(═O)R e , or R d and R 7 together with the atoms to which they are attached form a five or six-membered aliphatic ring; R e , independently, is selected from the group consisting of hydrogen, C 1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or two R e groups taken together with a nitrogen to which they are attached to form a five or six-membered aliphatic ring; R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, are selected from the group consisting of hydrogen, C 1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, OR e , C(═O)R e , C(═O)OR e , OC(═O)R e , C(═O)N(R e ) 2 , C(═O)NR e SO 2 R e , N(R e ) 2 , NR e C(═O)R e , NR e C(═O)N(R e ) 2 , CN, NO 2 , CF 3 , OCF 3 , SR e , SOR e , SO 2 R e , SO 2 N(R e ) 2 , and OSO 2 CF 3 ; R 7 is selected from the group consisting of hydrogen, C 1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and n is 1, 2, 3, 4, or 5, or a pharmaceutically acceptable salt or hydrate thereof.