Patent ID: 8790898

Claim:
A method to induce neutralizing antibodies against HIV-1 comprising administering to a mammal a chimeric peptide comprising a caveolin-1 binding domain (CBD1) of an HIV-1 gp41 peptide fused to a T helper epitope or at least two chimeric peptides comprising a caveolin-1 binding domain (CBD1) of an HIV-1 gp41 peptide fused to a T helper epitope, wherein: a. said caveolin-1 binding domain (CBD1) of an HIV-1 gp41 peptide consists of a peptide selected from the group consisting of: (a) X n WNNMTW (SEQ ID No: 28), wherein X is any amino acid and n is a number from 1 to 3; (b) X n WNNMTWMQWZ p (SEQ ID No: 29), wherein X and Z are any amino acid or Z is DK, n is 1, 2 or 3 and p is a number from 1 to 3; (c) IWNNMTW (SEQ ID NO:50); and (d) IWNNMTWMQW (SEQ ID NO:51); and, b. said T helper epitope is from a peptide selected from the group consisting of a tetanus toxin peptide, an HIV-1 Gag 24 peptide and an HIV-1 Env-gp120 peptide.