Patent ID: 8679535

Claim:
A sustained release oral tablet comprising a sustained release matrix comprising: a therapeutically effective amount of a medicament having an aqueous solubility of more than 10 g/1; a pH modifying agent which is an organic acid; a sustained release excipient comprising a gelling agent, an inert pharmaceutical diluent selected from the group consisting of monosaccharide, a disaccharide, a polyhydric alcohol, and mixtures thereof, said gelling agent comprising a Xanthan gum and a locust bean gum capable of cross-linking said Xanthan gum when exposed to an environmental fluid, the sustained release excipient further comprising an optional surfactant selected from the group consisting of monovalent alkyl carboxylates, acyl lactylates, alkyl ether carboxylates, N-acyl sarcosinates, polyvalent alkyl carbonates, N-acyl glutamates, fatty acid-polypeptide condensates, sulfuric acid esters, alkyl sulfates, ethoxylated alkyl sulfates, ester linked sulfonates, alpha olefin sulfonates, phosphated ethoxylated alcohols, monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium compounds, amidoamines, aminimides, N-substituted alkyl amides, N-alkyl betaines, sulfobetaines, and N-alkyl β-aminoproprionates, an ester of polyethyleneglycol, an ether of polyethyleneglycol, and mixtures of any of the foregoing, and an optional ionizable gel strength enhancing agent selected from the group consisting of an alkali metal sulfate, an alkali metal chloride, an alkali metal chloride, an alkali metal borate, an alkali metal bromide, an alkali metal citrate, an alkali metal acetate, an alkali metal lactate, an alkaline earth metal sulfate, an alkaline earth metal chloride, an alkaline earth metal chloride, an alkaline earth metal borate, an alkaline earth metal bromide, an alkaline earth metal citrate, an alkaline earth metal acetate, an alkaline earth metal lactate, and mixtures of any of the foregoing; the ingredients of the sustained release excipient being granulated together prior to incorporation of the medicament; the medicament being incorporated into the sustained release matrix together with the sustained release excipient and the pH modifying agent such that said tablet provides a sustained release of said medicament after oral administration to human patients for at least about 12 hours or at least about 24 hours, the tablet having a total weight from about 300 mg to about 1000 mg, and wherein the medicament is on oxybutynin.