Patent ID: 7427610

Claim:
A method of treating a tumor disease which is selected from the group consisting of breast cancer, prostate cancer, colon cancer, non-small-cell-lung cancer and primary dermal microvascular endothelial cell proliferation comprising administering to a subject in need thereof an effective amount of a compound of formula I wherein R 1 is hydrogen or C 1 -C 5 -alkyl, R 2 is C 1 -C 5 -alkoxy, C 1 -C 5 -alkyl, or —O—C n F m H o , n=1,2,3,4,5 or 6, m>1, m+o=2n+1, R 6 is hydrogen, R 7 is hydrogen, hydroxy, amino, or acylamino, or R 6 and R 7 together are an oxygen, oxime or O(C 1 -C 5 -alkyl)-oxime group, R 14 and R 15 are each hydrogen or together a methylene group or an additional bond, R 16 is hydrogen, or fluorine, R 17 is fluorine, or if R 16 is hydrogen, R 17 is also a CHXY, X is fluorine, or hydroxyl, Y is hydrogen or fluorine, if X is hydroxyl, Y is hydrogen, or X and Y together can be oxygen, R 18 is hydrogen or methyl, wherein in the B- and D-ring of the compound of formula I, the dotted lines can be up to two double bonds, provided that when a double bond is present in the D ring, only R 17 is present, or a pharmaceutically acceptable salt thereof.