Patent ID: 7390824

Claim:
A method for treating diabetes which comprises administering to a mammalian species in need of treatment a therapeutically effective amount of an aP2 inhibitor, wherein the aP2 inhibitor includes (a) an oxazole or analogous ring selected from the group consisting of a substituted benzoyl or biphenyl-2-oxazole-alkanoic acid derivative, an oxazole derivative, a 2-thio-4,5-diphenyloxazole S-derivative, a phenyl-heterocyclic oxazole derivative, a diaryloxazole derivative, a 4,5-diphenyloxazole derivative, an oxazole carboxylic acid derivative, a phenyloxazolyloxazole derivative, or a 2-(4,5-diaryl)-2-oxazolyl substituted phenoxyalkanoic acid derivative; and (b) a hydrogen bond donor or acceptor group and (c) an additional substituent which binds within and/or interacts with a discrete pocket within the aP2 protein defined by the amino acid residues designated Phe 16, Tyr 19, Met 20, Val 23, Val 25, Ala 33, Phe 57, Thr 74, Ala 75, Asp 76, Arg 78 in human aP2 (SEQ ID NO: 1).