Patent ID: 7101915

Claim:
A compound of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl, X is —O—, —CH 2 —, —NR 14 — wherein R 14 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O) p — wherein p is an integer of 0 to 2, Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH 2 — and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR 14 —, R 1 and R 4 , R 1 and R 2 , R 2 and R 3 , R 4 and R 5 , R 6 and R 7 , R 8 and R 9 , R 10 and R 11 , R 12 and R 13 , R 1 and —X—Y, or R 13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR 15 wherein R 15 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted arylsulfonyl and which may optionally be substituted, excluding compounds wherein one or more of R 6 , R 7 , R 8 and R 9 are halogen and the others are hydrogen, compounds wherein all of R 6 , R 7 , R 8 and R 9 are halogen and compounds wherein all of R 2 –R 13 are each independently selected from the group consisting of hydrogen, halogen and cyano, provided that R 1 is not hydrogen, fluorine, optionally substituted lower alkyl or optionally substituted lower alkoxy, all of R 2 , R 3 , R 4 , R 5 and R 12 are hydrogen, or R 13 is not hydrogen or halogen when R 6 , R 7 , R 8 and R 9 are all simultaneously hydrogen, and further provided that R 1 is not methyl or acetyloxy, R 13 is not hydrogen, optionally substituted lower alkoxycarbonyl or optionally substituted carbamoyl, or —X—Y is not methoxy when at least one of R 6 , R 7 , R 8 and R 9 is a substituent other than hydrogen, and excluding a compound of the formula (I′): wherein R 1′ is hydrogen or hydroxy and R 13′ is hydroxy or methoxy; or a pharmaceutically acceptable salt thereof.