Patent ID: 7189415

Claim:
A pharmaceutical composition comprising: a poorly water soluble drug having a drug solubility of 100 ml or more as a volume of solvent required for dissolving 1 g; a gel-forming water-soluble polymer; and a salt substance consisting of an alkali and a weak or strong acid and said salt substance having an endothermic standard enthalpy of solution (KJ/mol) or heat of solution (Kcal/mol) wherein said salt substance is selected from the group consisting of sodium bicarbonate, potassium bicarbonate, potassium sulfate, potassium chloride, sodium chloride and potassium dihydrogenphosphate; a surfactant in the range of 0.1 to 3 parts by weight based on 1 part by weight of the poorly water soluble drug; wherein said poorly water soluble drug is held in said gel forming water soluble polymer as a solid dispersion wherein said drug, said gel-forming water-soluble polymer and said salt substance are added in amounts (wt./wt %) of 1 to 30%, 3 to 60%, and 3 to 50%, respectively based on the total amount of the preparation, and without adding any organic acid, and wherein the poorly water soluble drug is 4′-[(2-methyl-1,4,5,6-tetrahydroimidazol[4,5-d][1]benzoazepin-6-yl)carbonyl]-2 phenylbenzanilide or a salt thereof.