Patent ID: 6867284

Claim:
A fluorine containing oligopeptide of formula: Y—B—A—X (FORMULA I) wherein: A is an amino acid residue of formula: where m is 0, B is a naturally or non-naturally occurring amino acid residue of formula: wherein R 2 contains from 1 to 20 carbon atoms is a non- polar, or polar but uncharged sidechain or is a side chain containing an acidic functionality; X is selected from the following: —CO 2 R 8 ; —H; —OR 8 ; —CF 3 ; —CONR 9 R 10 ; —CF 2 CONR 9 R 10 ; —NH.SO 2 R 25 or a heterocyclic group of formula: wherein U is sulphur, oxygen or NR 11 ; R 8 , R 9 , R 10 , R 11 and R 25 are, independently, hydrogen or a lower alkyl, lower alkenyl, aryl, or aralkyl group, and S and T are each independently either H or R 12 , where R 12 is a lower alkyl, lower alkenyl, aryl or aralkyl group, or can together form a ring; and Y is selected from (i) and (ii) below: wherein C is a natural or non-natural amino acid residue having a non-polar, polar but uncharged, or acidic side chain containing from 1 to 20 carbon atoms; D may be absent, but where present is a natural or non-natural amino acid having a hydrophobic side chain containing 1 to 20 carbon atoms; E may be absent, but where present is a natural or non-natural amino acid having an acidic side chain containing from 1 to 20 carbon atoms, or is a dicarboxylic acid containing up to 10 carbon atoms; F may be absent, but where present is a natural or non-natural amino acid having an acidic side chain containing from 1 to 20 carbon atoms, or is a dicarboxylic acid containing up to 10 carbon atoms; and Z may be absent, —H, or a group of formula R 7 CO − , where R 7 is a group containing from 1 to 20 carbon atoms which is chosen such that the group R 7 CO − together with the nitrogen atom to which it is attached forms an amide, urethane or urea linkage; where R 13 is an aliphatic or aromatic group containing from 1 to 25, carbon atoms and 0-5 oxygen atoms, 0-3 nitrogen atoms, 0 to 2 sulphur atoms and up to 9 other heteroatoms which may be the same or different; or a pharmaceutically acceptable salt or ester thereof.