Patent ID: 6914160

Claim:
A compound of formula (I) wherein: R 1 is selected from: a) phenyl, which is optionally substituted by 1-3 groups each independently selected from C 1- C 6 alkyl, CF 3 , halo, CN, NR 7 R 8 . SO 2 R 6 and OC 1- C 6 alkyl, and b) Aromatic Heterocycle, wherein said Aromatic Heterocycle is selected from pyridyl, pyrazinyl, pyrimidinyl, quinolinyl, quinoxalinyl, isoxazolyl and pyrazolyl, each aromatic heterocycle optionally substituted by 1-3 groups each independently selected from C 1- C 6 alkyl, SR 6 , SO 2 R 6 . NH 2 , CF 3 , halo, OH, OC 1- C 6 alkyl, NR 7 R 8 wherein R 8 may be optionally substituted by NH 2 , phenyl or Heterocycle, and OPh wherein Ph may be optionally substituted by 1-3 groups each independently selected from halo and C 1- C 6 alkyl; R 2 is selected from: a) phenyl, which is optionally substituted by methyl, fluoro, chloro, methoxy, CF 3 or SO 2 CH 3 , b) pyrazolyl, which is optionally substituted by methyl, and c) C(O)N(CH 3 ) 2 ; R 3 is selected from: a) phenyl, said phenyl being optionally fused to Heterocycle and said phenyl or said fused phenyl being optionally substituted by 1-3 groups each independently selected from C 1- C 6 alkyl, halo, CN and OC 1- C 6 alkyl, b) R 5 , c) cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, which is optionally substituted by C 1- C 6 alkyl; and d) Aromatic Heterocycle, wherein said Aromatic Heterocycle may be defined as a 5-6 membered aromatic heterocycle containing 1 or 2 nitrogen atoms, said ring optionally fused with a phenyl or a 3-8 membered cycloalkyl group. R 4 is H; R 5 is CONH 2 R 6 ; R 6 is methyl; R 7 is hydrogen or C 1- C 6 alkyl; R 8 is C 1- C 6 alkyl; or NR 7 R 8 forms a monocyclic saturated ring system containing between 3 and 7 ring atoms; x is 1; y is 0; and z is 0 or 1 wherein: Aromatic Heterocycle may be defined as a 5-6 membered aromatic heterocycle containing 1-4 heteroatoms each independently selected from N, O and S, said ring optionally fused with a phenyl or a 3-8 membered cycloalkyl group; Heterocycle is a 5-8 membered saturated or partially saturated ring containing 1-3 heteroatoms each independently selected from N. O and S, said ring optionally fused with phenyl; a tautomer thereof or a pharmaceutically acceptable salt, solvate or polymorph of said compound or tautomer.