Patent ID: 7060682

Claim:
An isolated receptor recognition factor implicated in the transcriptional stimulation of genes in target cells in response to the binding of a specific polypeptide ligand to its cellular receptor on said target cell, said receptor recognition factor having the following characteristics: a) apparent direct interaction with the ligand-bound receptor and activation of one or more transcription factors capable of binding with a specific gene; b) an activity demonstrably unaffected by the presence or concentration of second messengers; c) direct interaction with tyrosine kinase domains; and d) a perceived absence of interaction with G-proteins, said isolated receptor recognition factor consisting of a first polypeptide having an amino acid sequence of SEQ ID NO: 2, a second polypeptide having an amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, and a third polypeptide having an amino acid sequence of SEQ ID NO: 6.