Patent ID: 7166583

Claim:
A compound of formula I: wherein X is O, S, S(═O), or S(═O2); Y and Z are each independently selected from the group consisting of hydrogen, halogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl, C 2 –C 4 alkynyl, halo-C 1 –C 4 alkyl, hydroxy, C 1 –C 4 alkoxy, trifluoromethoxy, C 1 –C 4 alkanoyl, amino, amino-C 1 –C 4 -alkyl, N-(C 1 –C 4 -alkyl)amino, N,N-di(C 1 –C 4 -alkyl)amino, thiol, C 1 –C 4 alkylthio, sulfonyl, C 1 –C 4 alkylsulfonyl, sulfinyl, C 1 –C 4 alkylsulfinyl, carboxy, C 1 –C 4 alkoxycarbonyl, cyano, and nitro; R 1 is selected from the group consisting of halogen, hydroxy, C 1 –C 7 -alkoxy, aryloxy, amino, N-(C 1 –C, alkyl)amino, N,N-di(C 1 –C 7 -alkyl)amino, (C 1 –C 7 -alkyl)amino, amino-C 1 –C 7 alkoxy, C 1 –C 7 alkanoyl, aroyl, C 1 –C 7 alkanoyloxy, carboxy, an optionally substituted C 1 –C 7 alkyloxycarbonyl or aryloxycarbonyl, carbamoyl, N-(C 1 –C 7 -alkyl)carbamoyl, N,N-di(C 1 –C 7 -alkyl)carbamoyl, cyano, nitro, and a substituent of the formula II: wherein R 3 and R 4 are each independently selected from the group consisting of hydrogen, C 1 –C 4 alkyl, aryl or together with the nitrogen atom to which they are attached form an optionally substituted heterocycle or heteroaryl; m is an integer from 1 to 3; n is an integer from 0 to 3; Q 1 and Q 2 are each independently selected from the group consisting of oxygen, sulfur, wherein y 1 and y 2 are each independently selected from the group consisting of hydrogen, halogen, an optionally substituted C 1 –C 4 alkyl or aryl, hydroxy, C 1 –C 4 alkoxy, C 1 –C 4 alkanoyl, thiol, C 1 –C 4 alkylthio, sulfonyl, C 1 –C 4 alkylsulfonyl, sulfinyl, C 1 –C 4 alkylsulfinyl, cyano, and nitro or y 1 and y 2 taken together with the carbon atom to which they are attached form a carbonyl or imino group; R 2 is selected from the group consisting of hydrogen, optionally substituted C 1 –C 7 alkyl or aryl, and a protecting group selected from the group consisting of formyl, C 1 –C 7 alkanoyl, C 1 –C 7 alkoxycarbonyl, arylalkyloxycarbonyl, aroyl, arylalkyl, and C 1 –C 7 alkylsilyl; and pharmaceutically acceptable salts and solvates thereof.