Patent ID: 8031335

Claim:
A method for non-invasive detection of a disease, comprising: transferring a body fluid obtained from a patient to a sensor comprising a nano-scale surface structure to allow the body fluid to come in contact with the nano-scale surface structure; illuminating the body fluid and the nano-scale surface structure by a laser beam; scattering the laser beam by the body fluid and the nano-scale surface structure to produce a scattered light; identifying a spectral signature around 560 cm −1 , 1100 cm −1 , or 745 cm −1 in the Raman spectrum of the scattered light using a spectral analyzer, wherein the spectral signature comprises a spectral peak; calculating a signal-to-noise ratio using a peak intensity of the spectral signature and a background level in the Raman spectrum; determining if the signal-to-noise ratio for the spectral signature in the Raman spectrum is above a pre-determined threshold value; and alerting a possibility of a cancer or Human Immunodeficiency Virus (HIV) in the patient if the spectral peak is above the pre-determined threshold value.