Patent ID: 7604982

Claim:
A high-throughput screening method of antagonistic material of integrin, comprising the steps of; (a) immobilizing integrin α II b β 3 and/or α v β 3 ; (b) reacting ligand protein labeled with fluorescence and peptide pool of peptide library on the protein chip on which the integrin is immobilized; (c) washing the protein chip with buffer solution after the reacting; and (d) measuring the degree of ligand binding after the washing; said method providing a peptide having antagonistic activity of integrin α v β 3 that is selected from the group consisting of HSDVHK peptide (SEQ ID NO: 1), HGDVHK peptide (SEQ ID NO: 2), HHLLHK peptide (SEQ ID NO: 3), HGLVHK peptide (SEQ ID NO: 4), and HGDLHK peptide (SEQ ID NO: 5).