Patent ID: 7125860

Claim:
A cross-linked derivative of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I): wherein R 1 is H or a residue C1–C20, substituted or unsubstituted, derived from an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic aldehyde, provided that the said aldehyde is liquid at room temperature; R 2 is an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R is OH, O − , an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic alcoholic group, or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic amino group; the groups R 3 , equal or different from each other, are H, SO 3 − , or a residue of hemiesters of succinic acid or of heavy metal salts of hemiesters of succinic acid; the groups R 4 , equal or different from each other, are a percarboxylic group, or a group CH 2 OR 3 ; and the said hyaluronic acid derivatives are selected from the group consisting of: partial esters of hyaluronic acid esterified with aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic alcohols; hemiesters of succinic acid or heavy metal salts of the hemiesters of succinic acid with hyaluronic acid or with partial esters of hyaluronic acid; O-sulphated hyaluronic acid and derivatives thereof; amides of hyaluronic acid or a derivative thereof with an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic amine; percarboxylated hyaluronic acid and derivatives thereof; and hyaluronic acid salts with heavy metals.