Patent ID: 7863239

Claim:
A peptidomimetic consisting of a polypeptide attached to a scaffold wherein: i) the polypeptide is the amino acid sequence of a cysteine-knot growth factor family member from position CysIV+x to position CysV+y, wherein âˆ’5â‰¦xâ‰¦1 and 1â‰¦yâ‰¦6, with the proviso that x+y=âˆ’1, 0, 1 or 2, wherein two amino acid residues in said amino acid sequence have been replaced by a cysteine residue, wherein the first cysteine residue is introduced at position CysIV+p, which is located p residues C-terminal from CysIV, wherein 5â‰¦pâ‰¦12, wherein the second cysteine residue is introduced at position CysVâˆ’q, which is located q residues N-terminal from CysV, wherein 4â‰¦qâ‰¦12, wherein (pâˆ’q) is âˆ’3, âˆ’2, âˆ’1, 0, 1, 2 or 3, and wherein the first and second introduced cysteine residues are attached to each other via the scaffold, wherein cysteine residues in the amino acid sequence other than said first and second introduced cysteine residues are optionally replaced by an amino acid residue that is not reactive with the scaffold; and ii) wherein the scaffold is an aromatic molecule with at least two halomethyl substituents.