Patent ID: 8039493

Claim:
A compound of formula (I) wherein Y is arylene or heteroarylene, which arylene or heteroarylene can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy; R 1 is lower-alkyl, fluoro-lower-alkyl, aryl, aryl-lower-alkyl, heteroaryl, heteroaryl-lower-alkyl, cycloalkyl or cycloalkyl-lower-alkyl, wherein an aryl, heteroaryl or cycloalkyl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, CN, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, lower-alkoxy-carbonyl and phenyl; R 2 is lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkoxy-carbonyl-lower-alkyl, amino-carbonyl-lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, aryl-lower-alkyl, aryl-C(O), heteroaryl-lower-alkyl, heteroaryl-C(O) or heterocyclyl-lower-alkyl, wherein a cycloalkyl, aryl, heteroaryl or heterocyclyl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl, CN, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy and lower-alkoxy-carbonyl; R 3 is aryl or heteroaryl, which aryl or heteroaryl is substituted with R 4 SO 2 —, N(R 5 R 6 )SO 2 —, R 4 SO 2 NR 7 — or N(R 5 R 6 )SO 2 NR 7 —, and which aryl or heteroaryl can optionally be substituted with 1 to 3 additional substituents independently selected from the group consisting of hydroxy-lower-alkyl, halogen, CN, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy and lower-alkoxy-carbonyl; R 4 is lower-alkyl; R 5 , R 6 and R 7 independently from each other are hydrogen or lower-alkyl; and pharmaceutically acceptable salts and esters thereof; with the proviso that the compound is not N-[[3′-[(methylsulfonyl)amino][1,1′-biphenyl]-3-yl]methyl]-N-(3-pyridinylmethyl)-ethanesulfonamide.