Patent ID: 8222288

Claim:
A compound having Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein: X is O, or S; Y is O, S, or NR′; R 1 , R 2 , R 4 , R 5 , R 6 , and R 7 are independently H or optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclic, CO 2 R′, OCOR′, CONR′R″, NR″COR′, NR′SO 2 R″, SO 2 NR′R″, (C═NR′)NR″R′″, or NR′R″; or R 7 forms an aryl, cycloalkyl, or heterocyclic group with one of R 5 or R 6 ; R 8 is absent; R 9 represents a 6-chloro and a 5-fluoro group; and each R′, R″ and R′″ is independently H or optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heterocyclic; or R′ and R″, or R″ and R′″, form a ring; wherein one of R 3 and R 4 is CONRR′, and one of R and R′ is an optionally substituted cycloalkyl-alkyl or monocyclo-heterocycloalkyl group or a dihydroxyalkyl amino group not containing a hydroxyl group at the 3-position of the alkyl group.