Patent ID: 8691585

Claim:
A method for reducing the risk of pregnancy loss in a subject which comprises: (a) obtaining a sample from the subject; (b) quantitatively determining the amount of an early pregnancy associated molecular isoform of human chorionic gonadotropin (hCG) which isoform is recognized by the antibody produced by hybridoma cell line B152 (ATCC Designation No. HB-12467) in the sample; (c) comparing the amount of the early pregnancy associated molecular isoform of hCG in the sample determined in step (b) with a reference amount determined for samples from either temporally matched, normal pregnant subjects or non-pregnant subjects; and (d) administering to the subject an effective amount of the early pregnancy associated molecular isoform of hCG to reduce the risk of pregnancy loss, if the amount of the early pregnancy associated molecular isoform of hCG in the sample from the subject is less than the reference amount present in the samples from the temporally matched, normal pregnant subjects or from non-pregnant subjects, so as to thereby reduce the risk of pregnancy loss in the subject.