Patent ID: 8258145

Claim:
A method of treating anaplastic astrocytoma, glioblastoma, meningioma, or mesenchymal tumor in a mammal in need of such treatment, comprising intravenously administering to the mammal an effective amount of a compound according to Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 is C 1-3 alkyl; R 2 is halo, R 14 , OR 14 , SR 14 , NR 15 R 14 , or NR 14 (C═O)C 1-6 alkyl wherein R 15 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-8 carbocycle, C 3-8 heterocycle, C 6-10 aryl, or arylalkyl and R 14 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-8 carbocycle, C 3-8 heterocycle, C 6-10 aryl, or arylalkyl; R 3 , R 4 , R 6 -R 8 , R 10 -R 13 are independently halo, R 16 , NR 16 R 17 , OR 16 , or SR 16 wherein R 16 and R 17 are independently H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl provided that R 16 and R 17 are not both H; R 5 is H or C 1-3 alkyl; R 9 is H, halo, R 18 , OR 18 , SR 18 , NR 18 R 19 , or optionally R 9 and one of R 8 and R 10 together form a heterocycle, wherein R 18 and R 19 are independently H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 haloalkyl provided that R 18 and R 19 are not both H; and B, D, W, X, Y and Z are independently C or N, provided that at least one of B and D is N, no more than one of W, X, Y and Z are N, and when B, D, W, X, Y or Z is N then there is no substituent at the N.