Patent ID: 8062653

Claim:
A nitric oxide oligomer of formula A: wherein: L is —O— or —COO—; D is: (i) together or separately from L, a biologically active substance, in which case q is 1 to 4 inclusive; P is a polyester that is one of —[—X—] p —, where monomer X is polymerization compatible with —CH 2 COO—, or —[—Y—] p —, where monomer Y is polymerization compatible with —COCH 2 O—, wherein p is independently an integer from 2 to 100 inclusive; 1 or more independently selected repeats X are: —CH 2 COO— (glycolic acid moiety); —CH(CH 3 )COO— (lactic acid moiety); —CH 2 CH 2 OCH 2 COO— (dioxanone moiety); —CH 2 CH 2 CH 2 CH 2 CH 2 COO— (caprolactone moiety); —(CH 2 ) y COO— where y is one of the numbers 2, 3 or 4, or a number from 6 to 24 inclusive; or —(CH 2 CH 2 O) z CH 2 COO— where z is an integer between 2-24, inclusive; the order and composition of repeats X is selected to provide a desired degradation of moiety -L-P—R; 1 or more independently selected repeats Y are: —COCH 2 O— (glycolic ester moiety); —COCH(CH 3 )O— (lactic ester moiety); —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety); —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety); —CO(CH 2 ) m O— where m is one of the numbers 2, 3 or 4, or a number from 6 to 24 inclusive; or, —COCH 2 O(CH 2 CH 2 O) n — where n is integer between 2-24 inclusive; the order and composition of repeats Y is selected to provide a desired degradation of moiety -L-P—R; and R is according to one of the applicable following options (a) or (b): (a) where P is —[—X—] p , R can be an alkyl group, aryl, alkyl-aryl, an alicyclic group or alkyl-alicyclic, substituted with one or more —O—NO 2 ; and (b) where P is —[—Y—] p , R can be —NO 2 ; wherein if L is —COO—, then the corresponding P is —[—X—] p —; and wherein the biologically active substances are selected from the group consisting of phenols, thiophenols, naphthols, flavonoids, isoflavonoids, coumarins, chromones, chalcones, cinnamic acids, benzoic acids, acetophenones, benzophenones, alkaloids, catechins, catechols, aminoalcohols, aminosalicyclic acids, hydrocinnamic acids, phenolic acids, resorcinols, indoles and hydroquinones.