Patent ID: 7288562

Claim:
A compound having the structure of Formula I and its pharmaceutically acceptable salts, pharmaceutically acceptable enantiomers, diastereomers, N-oxides, wherein Ar represents an aryl ring which may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl (C 1 -C 4 ) amino or N-lower alkyl (C 1 -C 4 ) amino carbonyl; R 1 represents a hydrogen, hydroxy, hydroxymethyl, amino, alkoxy, carbamoyl or halogen (fluorine, chlorine, bromine or iodine); R 2 represents a C 3 -C 7 cycloalkyl ring in which from 1 to 4 hydrogen atoms are substituted with fluorine atoms, amides or sulphonamide derivatives; W represents (CH 2 ) p , where p represents 0 or 1; X represents no atom; Y represents (CH 2 ) q wherein q represents 0; Z represents oxygen, sulphur or NR 10 , wherein R 10 represents hydrogen or C 1-6 alkyl; Q represents (CH 2 ) n wherein n represents 1 to 4, or CHR 8 wherein R 8 represents H, OH, C 1-6 , alkyl, alkenyl, alkoxy, or CH 2 CHR 9 wherein R 9 represents H, OH, lower alkyl (C 1 -C 4 ) or lower alkoxy (C 1 -C 4 ); R 6 and R 7 are independently selected from H, CH 3 , COOH, CONH 2 , NH 2 or CH 2 NH 2 ; and R 4 represents a C 1 -C 15 saturated or unsaturated aliphatic hydrocarbon group in which from 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen, arylalkyl, arylalkenyl, heteroarylalkyl or heteroarylalkenyl having 1 to 2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulphur atoms with an option that any 1 to 3 hydrogen atoms on the ring in said arylalkyl, arylalkenyl, hetero arylalkenyl group may be substituted with lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxyl, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhaloalkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ) or N-lower alkylamino carbonyl (C 1 -C 4 ).