Patent ID: 6921774

Claim:
A compound represented by the formula I: wherein R 1 is hydrogen, C 1-6 -alkyl, cycloalkyl or cycloalkylalkyl; R 2 and R 3 are independently hydrogen, halogen, C 1-6 -alkyl, C 3-8 cycloalkyl or C 3-8 cycloalkyl-C 1-6 -alkyl or R 2 and R 3 together form a C 3-8 cycloalkyl; R 4 , R 5 , R 6 and R 7 are independently hydrogen, halogen, CF 3 , NO 2 , CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, OH, SH, NR 14 R 15 , wherein R 14 and R 15 are independently hydrogen or C 1-6 -alkyl; —COR 16 wherein R 16 is OH, C 1-6 alkyl, C 1-6 -alkoxy, NR 17 R 18 , wherein R 17 and R 18 are independently hydrogen or C 1-6 -alkyl; aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted one or more times with halogen, CF 3 , OCF 3 , CN, NO 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 thioalkyl, OH, SH or NR 24 R 25 , wherein R 24 and R 25 are independently hydrogen or C 1-6 alkyl; or R 4 and R 5 , or R 5 and R 6 , or R 6 and R 7 together form a fused, aromatic, saturated or partly saturated ring which optionally contains one or more heteroatoms O, N or S; R 8 , R 9 , R 10 , R 11 , and R 12 are independently hydrogen, halogen, CF 3 , OCF 3 , CN, NO 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, OH, SH, NR 19 R 20 , wherein R 19 and R 20 are independently hydrogen or C 1-6 alkyl; or R 8 , R 9 , R 10 , R 11 and R 12 are independently —COR 21 , wherein R 21 represents OH, C 1-6 alkoxy, NR 22 R 23 wherein R 22 and R 23 are independently hydrogen or C 1-6 -alkyl; or R 8 , R 9 , R 10 , R 11 and R 12 are independently aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted one or more times with halogen, CF 3 , OCF 3 , CN, NO 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, OH, SH, COR 26 , wherein R 26 is OH, C 1-6 alkoxy or C 1-6 alkyl; or NR 30 R 31 , wherein R 30 and R 31 are independently hydrogen or C 1-6 alkyl; R 8 and R 9 , or R 9 and R 10 , or R 10 and R 11 or R 11 and R 12 together form a fused, aromatic, saturated or partly saturated ring which optionally contains one or more heteroatoms O, N or S; Y is O, S, CH 2 or CH, and when Y is CH then the dotted line is a bond; n is 2, 3, 4, 5 or 6; Q represents C, P—OR 29 or S═O, wherein R 29 represents hydrogen or C 1-6 -alkyl; X is OR 13 or NR 27 R 28 , wherein R 13 , R 27 , and R 28 are independently hydrogen, C 1-6 -alkyl, aryl or aryl-C 1-6 -alkyl, wherein aryl may be substituted with halogen, CF 3 , OCF 3 , CN, NO 2 , or C 1-6 -alkyl, optionally R 27 and R 28 together form a ring which may contain further nitrogen, oxygen or sulfur atoms and the ring may optionally be partly saturated, R 29 and R 30 represent hydrogen, C 1-6 -alkyl, cycloalkyl or cycloalkylalkyl; or a pharmaceutically acceptable addition salt thereof.