Patent ID: 8030332

Claim:
A compound of formula I, or a pharmaceutically acceptable salt, wherein: A is pyridyl; L is D is pyridyl; E-G is G, attached to a carbon ring atom of ring E, is selected from the group consisting of —C 1-6 alkylene-L, —CH(OH)-L, —NH-L, —N(C 1-6 alkyl)-L, —NHC(O)NH-L, —NH(C(O)C 1-6 alkyl)-L, —O-L, —O-C 1-6 alkylene-L, —C(O)-L, —C(O)NH-L, —C(O)N(C 1-6 alkyl)-L, —C(O)NH(C 1-6 alkylene)-L, —C(O)N(C 1-6 alkyl)C 1-6 alkylene-L, and -L, wherein C 1-6 alkyl and C 1-6 alkylene are unsubstituted or substituted with halogen; M is selected from the group consisting of O, NH and N(C 1-6 alkyl); R a , in each instance in which it appears, is independently selected from the group consisting of 1) hydrogen, 2) C 1 -C 6 alkyl, 3) halogen, 4) aryl, 5) heterocycle, 6) C 3 -C 10 cycloalkyl, 7) OR 5 , and 8) CH 2 OR 5 , said alkyl, aryl, heterocycle and cycloalkyl is unsubstituted or substituted with at least one substituent selected from R 6 ; R 4 , in each instance in which it appears, is independently selected from the group consisting of 1) hydrogen, 2) halogen, 3) NO 2 , 4) CN, 5) CR 4 ═C(R 5 ) 2 , 6) C≡CR 5 , 7) (CR a 2 ) n OR 5 , 8) (CR a 2 ) n N(R 5 ) 2 , 9) (CR a 2 ) n C(O)R 5 , 10) (CR a 2 ) n C(O)OR 5 , 11) (CR a 2 ) n R 5 , 12) (CR a 2 ) n S(O) m R 5 , 13) (CR a 2 ) n S(O) m N(R 5 ) 2 , 14) OS(O) m R 5 , 15) N(R 5 )C(O)R 5 , 16) N(R 5 )S(O) m R 5 , 17) (CR a 2 ) n N(R 6 )R 5 , 18) (CR a 2 ) n N(R 5 )(CR a 2 ) n C(O)N(R 5 ) 2 , 19) (CR a 2 ) n N(R 5 )(CR a 2 ) n C(O)OR 5 , 20) N(R 5 )(CR a 2 ) n R 5 , 21) N(R 5 )(CR a 2 ) n N(R 5 ) 2 , 22) (CR a 2 ) n C(O)N(R 5 ) 2 , 23) (CR a 2 ) n C(O)NH(CR a 2 ) n R 5 , 24) (CR a 2 ) n C(O)NHC(R 5 ) 2 (CR a 2 ) n N(R 5 ) 2 and 25) C(O)NH(CR a 2 )(CR a 3 ); R 5 , in each instance in which it appears, is independently selected from the group consisting of 1) hydrogen, 2) unsubstituted or substituted C 1 -C 6 alkyl, 3) unsubstituted or substituted C 3 -C 10 cycloalkyl, 4) unsubstituted or substituted aryl, 5) unsubstituted or substituted heterocycle, 6) CF 3 , 7) unsubstituted or substituted C 2 -C 6 alkenyl, and 8) unsubstituted or substituted C 2 -C 6 alkynyl, or in the case where R 5 is attached to a nitrogen atom that is disubstituted with R 5 , each R 5 is independently selected from C 1 -C 6 alkyl, and the nitrogen atom together with each R 5 form a ring; R 6 , in each instance in which it appears, is independently selected from the group consisting of 1) hydrogen, 2) unsubstituted or substituted C 1 -C 6 alkyl, 3) halogen, 4) oxo, 5) OR 5 , 6) CF 3 , 7) unsubstituted or substituted aryl, 8) unsubstituted or substituted C 3 -C 10 cycloalkyl, 9) unsubstituted or substituted heterocycle, 10) S(O) m N(R 5 ) 2 , 11) C(O)OR 5 , 12) C(O)R 5 , 13) CN, 14) C(O)N(R 5 ) 2 , 15) N(R 5 )C(O)R 5 , 16) N(R 5 )C(O)OR 5 , 17) N(R 5 )C(O)N(R 5 ) 2 , 18) OC(O)N(R 5 ) 2 , 19) S(O) m R 5 , 20) OS(O) m R 5 , 21) NO 2 , 22) N(R 5 ) 2 ; 23) SC(O)R 5 , and 24) N(R 5 )S(O) m R 5 ; m is independently 0, 1 or 2; and n, in each instance in which it occurs, is independently selected from 0, 1, 2, 3, 4, 5 or 6.