Patent ID: 7345046

Claim:
A compound having the formula: wherein Q is thienyl; X is O or S; R 1 is hydrogen, or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkylsulfonyl, or arylsulfonyl; R 2 is hydrogen, or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkylsulfonyl, arylsulfonyl, alkylcarboxy, aminocarboxy, aminocarbonyl, or alkylsulfonamido; or COR 7 , CO 2 R 7 , CONR 8 R 9 , S(O) m R 10 , or SO 2 NR 11 R 12 ; R 3 is cyano, substituted or unsubstituted arylsulfonyl, or CONR 8 R 9 ; R 4 is hydrogen, or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl; or L-R 13 , wherein L is a C1-C10 saturated or unsaturated branched or unbranched carbon chain comprising one or more methylene groups, wherein one or more methylene groups are optionally independently replaced by O, N, or S; and wherein L is optionally substituted with one or two oxo groups and one or more C1-C10 branched or unbranched alkyl optionally substituted by one or more halogen atoms; R 5 is hydrogen, or substituted or unsubstituted alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, or heterocyclyl; or COR 7 , CO 2 R 7 , CONR 8 R 9 , or SO (m) R 10 ; R 6 is hydrogen, halogen, hydroxy, nitro, amino, cyano, alkoxy, alkylthio, methylenedioxy, or haloalkoxy; or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, alkylcarboxy, carboxyamino, carboxyamido, aminocarboxy, aminocarbonyl, or alkylsulfonamido; R 7 , R 8 , R 9 , R 10 , R 11 , and R 12 are independently selected from hydrogen, or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl; or R 8 and R 9 , or R 11 and R 12 taken together form a 3- to 7-membered carbocyclic or heterocyclic ring; R 13 is amino, alkylamino, or dialkylamino; or substituted or unsubstituted guanidino or heterocyclyl; m=0, 1, or 2; and n=0, 1, 2, or 3; or the tautomers or pharmaceutically acceptable salts thereof.