Patent ID: 8162880

Claim:
A device for delivering a therapeutic substance to the interior of a body lumen wall, comprising: a catheter including a catheter lumen; a balloon connected to said catheter, the interior of said balloon in communication with said catheter lumen, said balloon operable to be inflated by an inflation pressure exerted by a gas or liquid passed through said catheter lumen; a flexible lattice frame encircling at least a region including the central one third of said balloon, said frame requiring substantially more force to expand than said balloon, said frame configured to shrink and maintain engagement with said balloon after said balloon has been deflated after inflation, whereby said frame is removed with said balloon when said catheter is removed from the body; and a release coating comprising a first layer including a therapeutic substance applied over at least a portion of said lattice frame and the exterior of said balloon, which adheres to the interior of the body lumen wall upon inflation of the balloon and lattice, and is transferred to the body lumen wall where it remains after substantially concurrent deflation and removal of the balloon and lattice; wherein said balloon expands said lattice frame when inflated by said inflation pressure; and wherein said therapeutic substance within said coating diffuses into the body lumen wall through contact with said body lumen wall by said coating for a substantial amount of time after said balloon and lattice are deflated and removed.