Patent ID: 7589123

Claim:
A method of treatment comprising administering to a human or nonhuman animal a compound for the treatment of one or more conditions selected from the group consisting of hypersensitivity, smooth muscle disorders, spasmodic conditions, allergic conditions, inflammatory conditions and pain, the compound having general formula I: wherein: R 1 and R 2 are, independently of each other, selected from hydrogen, optionally substituted C 1-10 alkyl, optionally substituted —CO—(C 1-10 alkyl), optionally substituted C 3-10 cycloalkyl, optionally substituted —CO—(C 3-10 cycloalkyl), optionally substituted C 2-10 alkenyl, optionally substituted —CO—(C 2-10 alkenyl), optionally substituted aryl, and optionally substituted —CO-aryl, or R 1 and R 2 together represent an optionally substituted saturated or unsaturated C 1-10 alkylidene group, or an optionally substituted saturated or unsaturated C 3-10 cycloalkylidene group, or R 1 and R 2 together with the carbon atom to which they are attached represent an optionally substituted saturated or unsaturated organic ring containing 3, 4, 5, 6, 7 or 8 ring carbon atoms and optionally 1, 2 or 3 ring heteroatoms selected from O, N and S; R 3 is selected from the group consisting of C 1-10 alkyl, optionally substituted C 3-10 cycloalkyl, optionally substituted C 2-10 alkenyl, optionally substituted aryl, and C 1-10 alkyl substituted with one or more substituents, which may be the same or different, selected from: halo, C 1-6 alkyl, C 3-6 cycloalkyl, hydroxy, C 1-6 alkoxy, C 2-6 alkenyloxy, amino, nitro, C 1-6 alkylamino, C 2-6 alkenylamino, di-C 1-6 alkylamino, C 1-6 acylamino, di-C 1-6 acylamino, C 6-12 aryl, C 6-12 arylamino, di-C 6-12 arylamino, C 6-12 aroylamino, di-C 6-12 aroylamino, C 6-12 arylamido, carboxy, C 1-6 alkoxycarbonyl, (C 6-12 ar)(C 1-10 alkoxy)carbonyl, carbamoyl, and any of the above in which a hydrocarbyl moiety is itself substituted by halo, hydroxy, amino, nitro, carbamoyl or carboxy, but R 3 not being phenylethyl; R 4 , R 5 and R 6 are, independently of each other, selected from the group consisting of hydrogen, optionally substituted C 1-10 alkyl, OH, optionally substituted C 1-10 alkoxy, halo, optionally substituted aryloxy, optionally substituted (C 1-10 alkyl)-S(O) n — where n=0, 1 or 2, optionally substituted aryl-S(O) n — where n=0, 1 or 2, or R 4 and R 5 together represent an optionally substituted saturated or unsaturated organic chain containing 1, 2, 3, 4, 5, 6 or 7 chain carbon atoms and optionally 1, 2 or 3 chain heteroatoms selected from O, N and S, provided that the chain is at least 3 atoms long; with the proviso that, when R 1 ═R 2 =hydrogen, then any optionally substituted C 1-10 alkyl or optionally substituted C 2-10 alkenyl for R 3 must have a branch point at one or more of the α and β positions counted from the carbonyl group (or tautomeric form thereof) to which R 3 is attached; or a physiologically acceptable salt or complex thereof; excluding 2-[4-[3-oxo-5-phenyl-2-(3,4,5 -trimethoxybenzoyl)-pentyl]-phenoxy]-benzoic acid and its benzyl ester.