Patent ID: 7983850

Claim:
A method for diagnosis of multiple myeloma, comprising the steps of: (a) isolating plasma cells from an individual; (b) examining the mRNA levels of a group of genes comprising CCND1, MAF, MAFB, FGFR3, and MMSET or determining chromosomal translocation of genes comprising CCND1, MAF, MAFB, FGFR3, and MMSET; and (c) examining the mRNA levels of a group of genes comprising CST6, RAB7L1, MAP4K3, HRASLS2, TRAIL, IG, FGL2, GNG11, MCM2 and FLJ10709, wherein results from steps (b) and (c) classify the individual into one of multiple myeloma group 1 which has high levels of IG/FLG2 and low levels of GNG11, MCM2, FLJ10709, or group 2 which has high levels of GNG11 and low levels of IG/FLG2, MCM2, FLJ10709, or group 3 which has a spike in levels of CCND1, or group 4 which has high levels of MCM2, FLJ10709 and low levels of IG/FGL2, GNG11, or group 5 which has a spike in levels of MAF/MAFB, or group 6 which has high levels of CST6, RAB7L1, MAP4k3, HRASLS2 and low levels of TRAIL, or group 7 which has a spike in levels of FGFR3/MMSET.