Patent ID: 7473432

Claim:
A vesicular composition comprising: 1) vesicles having a lipid bilayer and consisting essentially of: i) a phosphatidylcholine; ii) a polyethyleneglycol-sorbitan-monooleate, a polyoxyethylene-oleoyl ether, or a nonaethyleneglycoloctylphenyl ether surfactant; and iii) a salt of an NSAID wherein said NSAID is diclofenac, ibuprofen or ketoprofen; and 2) a pharmaceutically acceptable, polar liquid medium, wherein the phosphatidylcholine and the surfactant of the vesicles are present in a molar ratio of between about 20/1 and about 7.5/1, the molar ratio of phosphatidylcholine to NSAID is between about 10/1 to about 1/1, the lipid bilayer is in the fluid lamellar phase, and the pH of the composition is above the pKa of the NSAID.