Patent ID: 8242146

Claim:
A method of minimizing gastrointestinal side effects frequently associated with the use of conventional NSAIDs comprising the simultaneous, sequential or separate administration to a patient in need thereof of (i) a first amount of 2-(2,6- dichlorophenyl) amino]benzeneacetic acid [INN: DICLOFENAC] or a pharmaceutically acceptable salt, ester, solvate, solvate of a salt, or solvate of an ester thereof; and (ii) a second amount of 3-Cyclopropylmethoxy-4-difluoro methoxy-N-(3,5-dichloro pyrid-4- yl)-benzamide [INN: ROFLUMILAST] or a pharmaceutically acceptable salt, solvate, N-oxide, solvate of a salt, or solvate of an N-oxide thereof; wherein the sum of the first and second amounts is a therapeutically effective amount.