Patent ID: 6844441

Claim:
A compound of the formula: wherein n is 0, 1, 2 or 3; R 1 is hydrogen or halo; each R 2 is independently hydrogen, halo, trifluoromethyl, cyano, SR 4 , OR 4 , SO 2 R 4 , OCOR 5 , or (C 1 -C 10 )alkyl wherein the alkyl group is optionally substituted by hydroxy, halo, cyano, N(R 4 ) 2 , SR 4 , trifluoromethyl, OR 4 , (C 3 -C 8 )cycloalkyl, (C 6 -C 10 )aryl, NR 4 COR 5 , COR 5 , SO 2 R 5 , OCOR 5 , NR 4 SO 2 R 5 and NR 4 CO 2 R 4 ; R 3 is tetrahydrofuranyl, tetrahydropyranyl or a silyl protecting group; X is halo, methanesulfonyloxy, benzenesulfonyloxy, p-toluenesulfonyloxy, m-nitrobenzenesulfonyloxy or p-nitrobenzenesulfonyloxy; R 4 and R 5 , for each occurrence, are each independently selected from hydrogen, (C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy, (C 3 -C 8 )cycloalkyl,(C 6 -C 10 )aryl, (C 2 -C 9 )heterocycloalkyl, (C 2 -C 9 )heteroaryl or (C 1 -C 6 )aryl wherein the alkyl group is optionally substituted by the group consisting of hydroxy, halo, carboxy, (C 1 -C 10 )alkyl-CO 2 , (C 1 -C 10 )alkylsulfonyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 10 )alkoxy, or (C 1 -C 6 )alkyl; and wherein the aryl, heterocycloalkyl and heteroaryl groups are optionally substituted by one to four groups consisting of halo, nitro, oxo, ((C 1 -C 6 )alkyl) 2 amino, pyrrolidine, piperidine, (C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkylthio and (C 1 -C 10 )alkyl wherein the alkyl group is optionally substituted by one to four groups selected from hydroxy, halo, carboxy, (C 1 -C 6 )alkyl-CO 2 , (C 1 -C 6 )alkylsulfonyl, (C 3 -C 8 )cycloalkyl and (C 1 -C 6 )alkoxy; or R 5 is N(R 4 ) 2 wherein R 4 is as defined above.