Patent ID: 8163699

Claim:
A method for treating an aortic valve stenosis in a subject, said method comprising administering to a subject in need of treatment for an aortic valve stenosis a therapeutically effective amount of a peptide/phospholipid complex, wherein the peptide is of the following Formula (I): X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 -X 14 -X 15 -X 16 -X 17 -X 18 -X 19 -X 20 -X 21 -X 22 Formula (I) or a pharmaceutically acceptable salt thereof, wherein: X 1 is Pro (P), Ala (A), Gly (G), Gln (0), Asn (N), Asp (D) or D-Pro (p); X 2 is an aliphatic amino acid; X 3 is Leu (L) or Phe (F); X 4 is an acidic amino acid; X 5 is Leu (L) or Phe (F); X 6 is Leu (L) or Phe (F); X 7 is a hydrophilic amino acid; X 8 is an acidic or a basic amino acid; X 9 is Leu (L) or Gly (G); X 10 is Leu (L), Trp (W) or Gly (G); X 11 is a hydrophilic amino acid; X 12 is a hydrophilic amino acid; X 13 is Gly (G) or an aliphatic amino acid; X 14 is Leu (L), Trp (W), Gly (G) or NaI; X 15 is a hydrophilic amino acid; X 16 is a hydrophobic amino acid; X 17 is a hydrophobic amino acid; X 18 is Gln (Q), Asn (N) or a basic amino acid; X 19 is Gln (Q), Asn (N) or a basic amino acid; X 20 is a basic amino acid; X 21 is an aliphatic amino acid; and X 22 is a basic amino acid.