Patent ID: 6858609

Claim:
A compound of formula a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein R 1 and R 2 are each independently selected from hydrogen; hydroxy; amino; C 1-6 alkyl; C 1-6 alkyloxy; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; Ar 1 ; mono- or di(C 1-6 alkyl)amino; mono- or di(C 1-6 alkyl)aminocarbonyl; dihydro-2(3H)-furanone; C 1-6 alkyl substituted with one or two substituents each independently selected from amino, imino, aminocarbonyl, aminocarbonylamino, hydroxy, hydroxyC 1-6 alkyloxy, carboxyl, mono- or di(C 1-6 alkyl)amino, C 1-6 alkyloxycarbonyl and thienyl; or R 1 and R 2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C 1-6 alkyl)aminoC 1-4 alkylidene; R 3 is one of hydrogen, Ar 1 , C 1-6 alkylcarbonyl, C 1-6 alkyl, C 1-6 alkyloxycarbonyl, and C 1-6 alkyl substituted with C 1-6 alkyloxycarbonyl; and R 4 , R 5 , R 7 and R 8 are each independently selected from hydrogen, hydroxy, halo, C 1-6 alkyl, C 1-6 alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; R 6 is aminocarbonyl; L is one of C 1-10 alkyl; C 3-10 alkenyl; C 3-10 alkynyl; and C 3-7 cycloalkyl; or L is C 1-10 alkyl substituted with one or two substituents independently selected from the group consisting of C 3-7 cycloalkyl; indolyl or indolyl substituted with one, two, three or four substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy, or C 1-6 alkylcarbonyl; and phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy, or C 1-6 alkylcarbonyl; and, Ar 1 is phenyl, or phenyl substituted with one, two or three substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyloxy, cyano, nitro or trifluoromethyl.