Patent ID: 7989434

Claim:
A heterocyclic linker compound selected from the group consisting of Formulas IIa and IIIa: wherein Q is CR 4 or N; V 1 , V 2 and V 3 are independently CR 4 or N provided that for formula IIa and IIIa at least one of Q, V 1 and V 2 is N; R 2 , R 3 and R 4 are independently selected from the group consisting of H, F, Cl, Br, I, OH, —N(R 5 ) 2 , —N(R 5 ) 3 + , C 1 -C 8 alkylhalide, carboxylate, sulfate, sulfamate, sulfonate, —SO 2 R 5 , —S(═O)R 5 , —SR 5 , —SO 2 N(R 5 ) 2 , —C(═O)R 5 , —CO 2 R 5 , —C(═O)N(R 5 ) 2 , —CN, —N 3 , —NO 2 , C 1 -C 8 alkoxy, C 1 -C 8 halosubstituted alkyl, polyethyleneoxy, phosphonate, phosphate, C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 2 -C 8 alkenyl, C 2 -C 8 substituted alkenyl, C 2 -C 8 alkynyl, C 2 -C 8 substituted alkynyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 1 -C 20 heterocycle, and C 1 -C 20 substituted heterocycle; or when taken together, R 2 and R 3 form a carbonyl (═O), or spiro carbocyclic ring of 3 to 7 carbon atoms; and R 5 and R 6 are independently selected from the group consisting of H, C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 2 -C 8 alkenyl, C 2 -C 8 substituted alkenyl, C 2 -C 8 alkynyl, C 2 -C 8 substituted alkynyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 1 -C 20 heterocycle, and C 1 -C 20 substituted heterocycle; where C 1 -C 8 substituted alkyl, C 2 -C 8 substituted alkenyl, C 2 -C 8 substituted alkynyl, C 6 -C 20 substituted aryl, and C 2 -C 20 substituted heterocycle are independently substituted with one or more substituents selected from the group consisting of F, Cl, Br, I, OH, —N(R 5 ) 2 , —N(R 5 ) 3 + , C 1 -C 8 alkylhalide, carboxylate, sulfate, sulfamate, sulfonate, C 1 -C 8 alkylsulfonate, C 1 -C 8 alkylamino, 4-dialkylaminopyridinium, C 1 -C 8 alkylhydroxyl, C 1 -C 8 alkylthiol, —SO 2 R 5 , —S(═O)R 5 , —SR 5 , —SO 2 N(R 5 ) 2 , —C(═O)R 5 , —CO 2 R 5 , —C(═O)N(R 5 ) 2 , —CN, —N 3 , —NO 2 , C 1 -C 8 alkoxy, C 1 -C 8 trifluoroalkyl, C 1 -C 8 alkyl, C 3 -C 12 carbocycle, C 6 -C 20 aryl, C 2 -C 20 heterocycle, polyethyleneoxy, phosphonate, and phosphate; R 7 is the side chain of an amino acid and is optionally protected with a protecting group; X and Y independently: are H; form a protecting group selected from the group consisting of Fmoc, Boc, carbobenzoxy (CBz), benzyhydryl, allyloxycarbonyl, and triphenylmethyl, or; form a reactive functional group selected from the group consisting of N-hydroxysuccinimide, para-nitrophenyl carbonate, para-nitrophenyl carbamate, pentafluorophenyl, haloacetamide, and maleimide; and m is 1, 2, 3, 4, 5, or 6.