Patent ID: 7354895

Claim:
A compound of general formula I or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 is selected from the group consisting of: C 1 -C 6 alkyl, substituted with one or more basic groups selected from amino, amidino and guanidino; six-membered aromatic heterocyclyl containing a single heteroatom, which heteroatom is nitrogen, and substituted with one or more basic groups selected from amino, amidino and guanidino; and six-membered aliphatic heterocyclyl containing a single heteroatom, which heteroatom is nitrogen; R 2 is selected from the group consisting of H, methyl, halogen, and hydroxy; R 3 is selected from the group consisting of COOR 5 , SO(OR 5 ), SO 3 R 5 , B(OR 5 ) 2 , Pâ•O(R 5 )(OR 5 ), tetrazole, and a carboxylic acid isostere; R 4 represents a -group; R 5 is H, C 1 -C 6 alkyl, or aryl; R 6 is C 1 -C 6 alkyl, aryl, cycloalkyl, or an optionally N-substituted H 2 Nâ€”CH(Z)â€”CONHâ€”CH(Z)â€” or H 2 Nâ€”CH(Z)â€” group; X is C(Z) 2 ; Y is selected from the group consisting of O and S; and Z is independently selected from the group consisting of H, C 1 -C 6 alkyl, aryl, and cycloalkyl.