Patent ID: 7067519

Claim:
Compounds of the general formula (I) wherein: X is O or S; n is the integer 1, 2, or 3; m is the integer 0, 1, 2, 3; R 1 , R 2 , R 3 , R 4 independently represent cyano, nitro, halogen, hydrogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, trifluoromethyl, trifluoromethoxy, cycloalkyloxy, aryloxy, aralkyloxy, heterocyclyloxy, heterocyclylalkyloxy, R 8 CO—, NR 9 R 10 CO—, R 9 R 10 N—, R 8 OOC—, R 8 SO 2 NH—, R 11 —CO—NH—; or R 5 represents aryl, aralkyl, lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl; R 6 represents hydrogen, lower alkyl, trifluoromethyl, —(CH 2 ) m —OH, —(CH 2 ) m —O-lower alkyl, —(CH 2 ) m —CO 2 H, —(CH 2 ) m —CO 2 -lower alkyl, —(CH 2 ) m CONH 2 , —(CH 2 ) m —CONH-lower alkyl, or —(CH 2 ) m —CON-(lower alkyl) 2 , or —(CH 2 ) m —N-(lower alkyl) 2 ; R 7 represents aryl, aralkyl, lower alkyl, lower alkenyl, cycloalkyl, cycloalkyl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl; R 8 represents lower alkyl, aryl, aralkyl, heterocyclyl or heterocyclyl-lower alkyl; R 9 and R 10 independently represent hydrogen, alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aralkyl, heterocyclyl or heterocyclyl-lower alkyl; R 11 represents lower alkyl, aryl, cycloalkyl, heterocyclyl, R 9 R 10 N— or R 8 O—; and optically pure enantiomers, mixtures of enantiomers, racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diastereoisomeric racemates, mixture of diastereoisomeric racemates, or meso forms and pharmaceutically acceptable salts thereof.