Patent ID: 8476309

Claim:
A compound of the formula wherein one of R 1 and R 2 can be hydrogen and the other is selected from the group consisting of cycloalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteralkylalkyl and heteroarylalkyl, wherein the ring portion of each can be optionally substituted with one, two, three, four or five substituents independently selected from a group consisting of halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, trifluoromethyl, carboxy, alkylcarboxy, carbonyl, hydroxyalkyl, oxoalkyl, carboxyalkyl, cyanoalkyl and carbamoyl; R 4 is selected from the group consisting of cycloalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteralkylalkyl and heteroarylalkyl, wherein each the ring portion of each can be optionally substituted with one, two, three, four or five substituents independently selected from a group consisting of halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, trifluoromethyl, carboxy, alkylcarboxy and carbamoyl; X is selected from the group consisting of S, CH 2 , CH(CH 3 ), CH(OH), C(CH 3 )(OH), C(CH 3 ) 2 , C(—U(CH 2 ) 1 U—), C((CH 2 ) 1 CH3) 2 , C(O), NH, S(O), S(O) 2 , C(O)NH, S(O)NH, and S(O) 2 NH; n is an integer from 1 to 6; U is selected from the group consisting of CH 2 , S, and O; and R 3 is selected from the group consisting of H, OH, OCH 3 , O((CH 2 ) 1 CH 3 ), SH, SCH 3 , NH 2 , NHCH 3 , and N(CH 3 ) 2 , and pharmaceutically acceptable salts thereof.