Patent ID: 7423031

Claim:
A compound of Formula I: in which: R 1 and R 2 taken together with the carbon atoms to which R 1 and R 2 are attached form a phenyl ring optionally substituted by 1 to 3 substituents selected from halo, cyano, nitro, amino, methanesulfonyl, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 3 , R 4 and R 5 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; and —X—Y— is selected from —CH(-Z)—CH 2 — and —CZ=CH—; wherein -Z is selected from formula (c),(d) and (e): wherein R 6 , R 8 and R 9 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 7 is selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —C(O)OR 11 and —C(O)R 11 ; wherein R 11 is hydrogen or C 1-6 alkyl; R 10 is selected from C 1-6 alkyl, —NR 11 R 12 , C 6-10 aryl-C 0-4 alkyl, pyridinyl-C 0-4 alkyl, pyrimidinyl, quinolinyl, isoxazolyl, thiazolyl and C 3-10 cycloalkyl-C 0-4 alkyl; wherein any alkyl is optionally substituted with —NR 11 R 11 , C 1-6 alkoxy or hydroxy; and wherein any cycloalkyl, aryl or heteroaryl is optionally substituted by 1 to 3 substituents selected from halo, hydroxy, cyano, amino, nitro, —C(O)OR 11 , —C(O)NR 11 R 11 , —SNR 11 R 11 , —S(O)NR 11 R 11 , —S(O) 2 NR 11 R 11 , C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; wherein R 11 is hydrogen or C 1-6 alkyl; R 12 is C 3-12 cycloalkyl optionally substituted with amino; or R 9 and R 10 together with the nitrogen to which R 9 and R 10 are attached form piperazinyl or morpholino; or a pharmaceutically acceptable salt thereof.