Patent ID: 8288408

Claim:
A method of treating a cancer characterized by elevated MEK signaling wherein the cancer is melanoma, pancreatic cancer, thyroid cancer, colorectal cancer, lung cancer, breast cancer, prostate cancer, endometrial cancer and ovarian cancer in a mammal comprising administering to said mammal a therapeutically effective amount of a compound according to formula I: and salts thereof, wherein: Z 1 is CR 1 ; R 1 is H, C 1 -C 3 alkyl, halo, CF 3 , CHF 2 , CN, OR A or NR A R A ; R 1â€² is H, C 1 -C 3 alkyl, halo, CF 3 , CHF 2 , CN, OR A , or NR A R A ; wherein each R A is independently H or C 1 -C 3 alkyl; Z 2 is CR 2 ; Z 3 is CR 3 or N; R 2 and R 3 are independently selected from H, halo, CN, CF 3 , â€”OCF 3 , or C 1-6 alkoxy; R 4 is H or C 1 -C 6 alkyl; Y is Wâ€”C(O)â€”; W is R 5 is H or C 1 -C 12 alkyl; X 1 is OR 11â€² ; R 11â€² is independently H or C 1 -C 12 alkyl; X 4 is R 6 is H, halo, C 1 -C 6 alkyl, SR 16 , C 2 -C 8 alkenyl or C 2 -C 8 alkynyl; R 6â€² is H, halo or C 1 -C 6 alkyl; p is 0, 1 or 2; n is 0, 1, 2 or 3; wherein said alkyl of R 11â€² is optionally substituted with one or more groups independently selected from (CR 19 R 20 ) n OR 16 or R 21 ; R 16 is independently H or C 1 -C 12 alkyl; R 19 and R 20 are independently selected from H or C 1 -C 12 alkyl; R 21 is C 1 -C 12 alkyl or carbocyclyl.