Patent ID: 7348001

Claim:
An isolated antibody comprising a heavy chain immunoglobulin variable domain sequence and a light chain immunoglobulin variable domain sequence, wherein the antibody binds to Tie1 ectodomain and comprises: (1) the heavy chain immunoglobulin variable domain comprising a CDR1 that consists of MYGMV (amino acids 31-35 of SEQ ID NO:114), a CDR2 that consists of VISPSGGNTGYADSVKG (amino acids 50-66 of SEQ ID NO:114), and a CDR3 that consists of APRGYSYGYYY (amino acids 99-109 of SEQ ID NO:114) and the light chain immunoglobulin variable domain comprising a CDR1 that consists of RASQGIGHYLA (amino acids 24-34 of SEQ ID NO:116), a CDR2 that consists of TASTLQS (amino acids 50-56 of SEQ ID NO:116), and a CDR3 that consists of QQFNSYPHT (amino acids 89-96 of SEQ ID NO:116); (2) the heavy chain immunoglobulin variable domain comprising a CDR1 that consists of IYGMA (amino acids 31-35 of SEQ ID NO:64), a CDR2 that consists of VISPSGGQTFYADSVKG (amino acids 50-66 of SEQ ID NO:64), and a CDR3 that consists of VYYYGMDV (amino acids 99-106 of SEQ ID NO:64) and the light chain immunoglobulin variable domain comprising a CDR1 that consists of RASQSVSSYLA (amino acids 28-38 of SEQ ID NO:66), a CDR2 that consists of DASNRAT (amino acids 54-60 of SEQ ID NO:66), and a CDR3 that consists of QQRSKWPRT (amino acids 93-101 of SEQ ID NO:66); or (3) the heavy chain immunoglobulin variable domain comprising a CDR1 that consists of GYAMW (amino acids 31-35 of SEQ ID NO:84), a CDR2 that consists of SISPSGGATAYADSVKG (amino acids 50-66 of SEQ ID NO:84), and a CDR3 that consists of DAGSYYWGWFDP (amino acids 99-110 of SEQ ID NO:84) and the light chain immunoglobulin variable domain comprising a CDR1 that consists of RASQSISSYLA (amino acids 28-38 of SEQ ID NO:86), a CDR2 that consists of DASSRVT (amino acids 54-60 of SEQ ID NO:86), and a CDR3 that consists of LQRSSWPRT (amino acids 93-101 of SEQ ID NO:86).