Patent ID: 6972340

Claim:
A compound of formula (I) or a therapeutically acceptable salt, wherein A is selected from the group consisting of wherein the dotted line is either absent or is a single bond; B is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, D is selected from the group consisting of wherein Z is selected from the group consisting of alkoxy, alkyl, amino, cyano, nitro, CO 2 P 1 , SO 3 H, PO(OH) 2 , CH 2 PO(OH) 2 , CHFPO(OH) 2 , CF 2 PO(OH) 2 , and C(═NH)NH 2 ; wherein P 1 and P 2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, arylalkyl, cycloalkyl and (cycloalkyl)alkyl; R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of hydrogen, alkoxy, alkyl, aryl, arylalkyl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, nitro, NR A R B , NR A R B C(O), NR A R B C(O)alkyl and NR A R B C(O)alkenyl, wherein R A and R B are independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, alkylsulfonyl, aryl, arylalkylcarbonyl, arylcarbonyl, arylsulfonyl and (R C R D N)carbonyl wherein R C and R D are independently selected from the group consisting of hydrogen, alkyl, aryl, and arylalkyl; L is selected from the group consisting of —(CH 2 ) m X 1 (CH 2 ) n CH(R 8 )C(R 9A )(R 9B )X 2 (CH 2 ) p C(O)N(R 10 )CH(CO 2 R 11 )(CH 2 ) q X 3 —; —(CH 2 ) m X 1 (CH 2 ) n CH(R 8 )C(R 9A )(R 9B )X 2 (CH 2 ) p EC(O)N(R 10 )CH(CO 2 R 11 )(CH 2 ) q X 3 —; —(CH 2 ) m X 1 (CH 2 ) n CH(R 8 )C(R 9A )(R 9B )X 2 (CH 2 ) p X 3 —; —(CH 2 ) m X 1 (CH 2 ) n CH(R 8 )C(R 9A )(R 9B )X 2 (CH 2 ) p X 3 (CH 2 ) q X 4 —; and —(CH 2 ) m X 1 (CH 2 ) n CH(R 8 )C(R 9A )(R 9B )X 2 (CH 2 ) p E(CH 2 ) q X 3 —, wherein each group is drawn with the left end attached to A and the right end attached to B; m, n, p and q are independently between 0-4; R 8 is selected from the group consisting of hydrogen, hydroxy, NR A R B and (NR A R B )alkyl; R 9A and R 9B are independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl and R E R F Nalkyl, wherein R E and R F are independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl and alkanoyl, or R 9A and R 9B taken together are oxo; R 10 is selected from the group consisting of hydrogen, alkyl, alkanoyl and alkoxycarbonyl; R 11 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, arylalkyl, cycloalkyl, and (cycloalkyl)alkyl; E is selected from the group consisting of aryl and cycloalkyl; X 1 , X 2 , X 3 , and X 4 are independently absent or are independently selected from the group consisting of NR G , O, S, S(O) and S(O) 2 , wherein R G is selected from the group consisting of hydrogen, alkyl, alkanoyl and alkoxycarbonyl; and W 1 , W 2 , W 3 and W 4 are independently selected from the group consisting of CH, CH 2 , N, NH and O.