Patent ID: 7342024

Claim:
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, pyridyl, pyrimidyl, indolyl, quinolinyl, thienyl, pyridonyl, oxazolyl, oxadiazolyl, thiadiazolyl, or imidazolyl; or oxides thereof when Ar is a heteroaryl; Y is —COOH, or —C 1-6 alkyl(C 1-4 alkyl) n —COOH, wherein the —C 1-6 alkyl is optionally substituted with halogen, alkoxy, hydroxy or nitrile, and the (C 1-4 alkyl) substituents are optionally linked to form a C 3-4 cycloalkyl ; wherein n is 0, 1, 2, 3 or 4; R is H or —C 1-6 alkyl; R 1 is H, or —C 1-6 alkyl, —C 3-6 cycloalkyl, —C 1-6 alkoxy, —C 2-6 alkenyl, —C 3-6 alkynyl, heteroaryl, or heterocycle group, optionally substituted with 1-3 independent haloC 1-6 alkyl, —C 1-6 alkyl, —C 1-6 alkoxy, OH, amino, —(C 0-6 alkyl)—SO p —(C 1-6 alkyl), nitro, CN, ═N—O—C 1-6 alkyl, —O—N═C 1-6 alkyl, or halogen substituents, wherein p is 0, 1 or 2; R 2 is H, halogen, —CN, —NO 2 , —C 1-6 alkyl, C 3-6 cycloalkyl, —O—C 3-6 cycloalkyl, O—C 1-6 alkyl, O—C 3-6 cycloalkyl-C 1-6 alkyl(C 3-6 cycloalkyl)(C 3-6 cycloalkyl), —C 1-6 alkoxy, phenyl, heteroaryl, heterocycle, amino, —C(O)—C 1-6 alkyl, —C(O)—O—C 1-6 alkyl, —C 1-6 alkyl(═N—OH), —C(N═NOH)C 1-6 alkyl, —C 0-6 alkyl(oxy)C 1-6 alkyl-phenyl, —SO k NH(C 0-6 alkyl), or —(C 0-6 alkyl)-SO k —(C 1-6 alkyl), wherein the phenyl, heteroaryl or heterocycle is optionally substituted with halogen, —C 1-6 alkyl, —C 1-6 alkoxy, hydroxy, amino, or —C(O)—O—C 1-6 alkyl, and wherein the alkyl or cycloalkyl is optionally substituted with 1-6 independently selected halogens or —OH, and wherein k is 0, 1, or 2; R 3 is selected from H, halogen, CN, —C 1-6 alkyl, —C 3-6 cycloalkyl, nitro, —C(O)—C 1-6 alkyl, —C(O)—O—C 0-6 alkyl, —SO n′ NH(C 0-6 alkyl), or —(C 0-6 alkyl)-SO n′ —(C 1-6 alkyl), O—C 1-6 alkyl, O—C 3-6 cycloalkyl, wherein n′ is 0, 1, or 2 and wherein the alkyl and cycloalkyl is optionally substituted with 1-6 independently selected halogen or OH.