Patent ID: 7935847

Claim:
A C-nitroso compound having a molecular weight ranging from 75 to 1000 grams per mole which releases nitroxyl ion in human blood in a second order reaction but not in a pseudo first order reaction, comprising a tertiary carbon atom, a nitroso group covalently bonded to the tertiary carbon atom, a carbon acid of pKa less than about 30 covalently bonded to the tertiary carbon atom, and an electron withdrawing moiety covalently bonded to the carbon acid, where the tertiary carbon is covalently bonded to a ring atom of a ring containing 5 or 6 carbon atoms, the C-nitroso compound having a substituent Q which is attached to the tertiary carbon and which consists of a chain moiety containing from 0 to 12 chain atoms consisting of 0 to 10 carbon atoms, 0 to 5 nitrogen atoms and 0 to 5 oxygen atoms covalently bonded to a cyclic moiety which is monocyclic, bicyclic, tricyclic, tetracyclic or pentacyclic and contains 5 to 24 ring atoms consisting of 2 to 20 carbon atoms, 0 to 4 nitrogen atoms, 0 to 2 oxygen atoms and 0 to 2 sulfur atoms and when the chain moiety consists of no chain atoms, the cyclic moiety is covalently bonded to the tertiary carbon; the electron withdrawing moiety being selected from the group consisting of sulfonyl, cyano, fluoro, chloro, iodo, bromo; halobenzyl where the halo is fluoro, chloro, bromo, iodo; acyl selected from the group consisting of acetyl and t-butyroyl; acetylbenzyl; and carbonyl.