Patent ID: 8840866

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof; wherein n is an integer from one to six; A 4 is N; A 1 , A 2 , A 3 , and A 5 are independently —CH, or —CR 2 , as permitted; R 1 is: —(CH 2 ) p NR a R b , wherein R a and R b are independently hydrogen, ethyl, propyl, isopropyl, butyl, t-butyl, isobutyl hydroxy(C 1-4 )alkyl or halo(C 1-4 )alkyl, and p is an integer from 0 to 5; hydroxy, (C 1-4 ) alkoxy, hydroxy(C 1-4 )alkyl, halogen, cyano, nitro, (C 1-4 )alkyl, halo(C 1-4 )alkyl, formyl, —NHCO(C 1-4 alkyl), or —OCO(C 1-4 alkyl); R 2 is: wherein, q is an integer from 1 to 10, Rx and Ry are hydrogen, hydroxy or C 1-4 alkyl; t is 0, 1, 2 or 3; Z is hydroxy, halogen, benzoyloxy substituted with halogen, benzyloxy substituted with halogen, phenyl(C 1-4 )alkyl substituted with halogen, aryloxy substituted with halogen, or a C 6-10 aryl substituted with halogen; and R 30 , R 31 , R 32 and R 33 are in each instance independently hydrogen, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, or hydroxy(C 1-4 alkyl; wherein Rx and Ry are hydrogen, hydroxy or C 1-4 alkyl; t is 0, 1, 2 or 3; Y is halogen, benzoyloxy substituted with halogen, phenyl(C 1-4 )alkyl substituted with halogen, aryloxy substituted with halogen, or C 6-10 aryl substituted with halogen; U is hydrogen, hydroxy, halogen, benzoyloxy substituted with halogen, phenyl(C 1-4 )alkyl substituted with halogen, aryloxy substituted with halogen, or C 6-10 aryl substituted with halogen; and R 34 , R 35 , R 36 , R 37 , R 38 , R 39 and R 40 are in each instance independently hydrogen, halogen, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, or hydroxy(C 1-4 )alkyl; iii. NR′R″, wherein at least one of R′ and R″ is (CH 2 ) d X, where X is halogen, and d is an integer from 1 to 4; the other of R′ and R″ is hydrogen, C 1-4 -alkyl, halo(C 1-4 )alkyl, or hydroxy(C 1-4 alkyl; iv. halo(C 1-4 )alkyl; or v. an ether having the structure: [halo(C 1-4 )alkyl-O—(C 1-4 )alkyl]-; and R 7 and R 8 are each hydrogen.