Patent ID: 8507696

Claim:
A crystalline intermediate of formula (VII): wherein R 1 and R 2 are each independently selected from the group consisting of hydrogen, and C 1-6 alkyl; R 3 is selected from benzoyl or benzyl, wherein the benzoyl or benzyl are each substituted with 0, 1, 2 or 3 substituents independently selected from —OH, —O(C 1-4 alkyl), —NH 2 , —NH(C 1-4 -alkyl), —N(C 1-4 -alkyl) 2 , amides, —OCO(C 1-4 -alkyl) and (C 1-4 -alkyl); R 5 and R 6 are each independently selected from the group consisting of hydrogen, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, phenyl and benzyl, wherein the phenyl or benzyl are substituted with 0, 1, 2, or 3 substituents independently selected from halogen, hydroxyl, C 1-3 alkyl, and NH 2 ; or R 5 and R 6 are taken together with the carbons on which they are attached to form a 5-6 unconjugated membered carbocyclic ring; R 11 and R 12 are each independently selected from the group consisting of hydrogen and a base stable oxygen protecting group; or R 11 and R 12 are taken together to form a 5 membered heterocyclyldiyl of structure (a): wherein R 19 and R 20 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and phenyl, or R 19 and R 20 together represent a fluorenyl moiety of structure (b): and R 13 is wherein R 14 , R 15 , R 16 , R 17 , and R 18 are each independently selected from the group consisting of H, NO 2 , —NH 3 + , —COH, —CO(C 1-4 alkyl), —COCl, —COOH, —COO(C 1-4 alkyl), —NR 3 + , —SO 3 H, nitrile, —CF 3 and halogen, wherein at least one of R 14 , R 15 , R 16 , R 17 , and R 18 is selected from the group consisting of NO 2 —NH 3 + , —COH, —CO(C 1-4 alkyl), —COCl, —COOH, —COO(C 1-4 alkyl), —NR 3 + , —SO 3 H, nitrile, —CF 3 and halogen and the other of R 14 , R 15 , R 16 , R 17 and R 18 are hydrogen.