Patent ID: 7579483

Claim:
A process for preparing a compound of formula I: wherein R 1 is chosen from: hydrogen; C 1 -C 10 alkyl; C 1 -C 10 alkyl substituted with one or more of halogen, hydroxy, alkoxy, phenoxy, nitro, cyano, carboxyl, —C(═O)O(C 1 -C 4 )alkyl, —CONH 2 , aryl, or heteroaryl; said aryl or heteroaryl substituted with one or more of (C 1 -C 4 )alkyl, halogen, hydroxy, alkoxy, phenoxy, nitro, cyano, carboxyl, —C(═O)O(C 1 -C 4 )alkyl, and —CONH 2 ; aryl and aryl substituted with one or more of (C 1 -C 4 )alkyl, halogen, hydroxy, alkoxy, phenoxy, nitro, cyano, carboxyl, —C(═O)O(C 1 -C 4 )alkyl, and —CONH 2 ; and heteroaryl and heteroaryl substituted with one or more of (C 1 -C 4 )alkyl, halogen, hydroxy, alkoxy, phenoxy, nitro, cyano, carboxyl, —C(═O)O(C 1 -C 4 )alkyl, and —CONH 2 ; R 2 is chosen from: hydrogen; C 1 -C 10 alkyl and C 1 -C 10 alkyl substituted with one or more of halogen, hydroxyl, alkoxy, aryloxy, nitro, cyano, carboxyl, —C(═O)Oalkyl, —C(═O)Oaryl, —CONH 2 , aryl, or heteroaryl; aryl and aryl substituted with one or more of (C 1 -C 4 )alkyl, halogen, hydroxy, alkoxy, phenoxy, nitro, cyano, carboxyl, —C(═O)O(C 1 -C 4 )alkyl, and —CONH 2 ; and heteroaryl and heteroaryl substituted with one or more of (C 1 -C 4 )alkyl, halogen, hydroxy, alkoxy, phenoxy, nitro, cyano, carboxyl, —C(═O)O(C 1 -C 4 )alkyl, and —CONH 2 ; R 3 is chosen from: hydrogen, chlorine, fluorine, hydroxy, cyano, nitro, alkoxy, aryloxy, thioalkyl, amino, aminoalkyl, aminoaryl, fluoroalkyl, C 1 -C 10 alkyl, C 1 -C 10 alkyl substituted with one or more of fluorine, hydroxyl, alkoxy, aryloxy, aryl or heteroaryl; R 4 is chosen from: hydroxyl; C 1 -C 10 alkoxy; C 1 -C 10 alkoxy substituted with one or more of fluorine, alkoxy, aryloxy, aryl, or heteroaryl; NR 5 R 6 , where R 5 and R 6 are the same or different and are chosen from hydrogen; C 1 -C 6 alkyl substituted with one or more of halogen, hydroxyl, alkoxy, aryloxy, nitro, cyano, carboxyl, carboxyalkyl, carboxyaryl, or carbonylamino; and SO 2 R 7 in which R 7 is chosen from alkyl, aryl and heteroaryl, said aryl and heteroaryl substituted with one or more of halogen, hydroxy, amino, nitrile, nitro or C 1 -C 6 alkyl; or R 5 and R 6 taken together form a monocylic 4-7 membered ring or bicyclic 8-12 membered ring; said process comprising the steps of: a) rearranging a compound of formula II wherein X and Y are independently chosen from bromine, chlorine, iodine, and triflate; in the presence of a transition metal catalyst to form a compound of formula III b) followed by reacting said compound of formula III with a compound of formula IV R 4 —C(═O)—CH═CH 2 (IV) in the presence of a transition metal catalyst.