Patent ID: 8236349

Claim:
A pharmaceutical composition comprising a plurality of multiparticulates, each of said multiparticulates comprising: (a) a core comprising a drug, said core being surrounded by a coating selected from the group consisting of (i) a water-permeable, substantially drug impermeable coating and (ii) an anti-enteric coating; (b) said core further comprising a dissolution enhancer and a matrix material that is solid at 25° C. and having a melting point lower than the melting point of said drug and being present in an amount of at least 30 wt % of said core and wherein said matrix material is selected from the group consisting of alkyl-containing glycerols, hydrogenated cottonseed oil, and mixtures thereof; (c) said core further comprising a water-swellable swelling agent, said water-swellable swelling agent being capable of imbibing fluid and swelling so as to rupture said coating or disintegrate said core, thereby releasing said drug.