Patent ID: 8394960

Claim:
A compound having the formula: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the dashed line indicates an optional and additional bond and wherein: M is —O— or —S—; R 1 is H, alkyl, alkenyl, alkynyl, -(alkylene) m -aryl, -(alkylene) m -cycloalkyl, -(alkylene) m -heteroaryl, -(alkylene) m -heterocycloalkyl or -(alkylene) m -heterocycloalkenyl, wherein any aryl, cycloalkyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl group can be optionally substituted on a ring carbon or ring nitrogen atom with up to 3 substituents, which may be the same or different, and are selected from halo, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, —OR 6 , -(alkylene) m -N(R 6 ) 2 , —C(O)OR 6 , —NHC(O)R 6 , —C(O)N(R 6 ) 2 , —S(O) 2 R 7 , —CN, —OH, —NO 2 , -(alkylene) m -aryl, -(alkylene) m -cycloalkyl, -(alkylene) m -heteroaryl, -(alkylene) m -heterocycloalkyl and -(alkylene) m -heterocycloalkenyl; and wherein any aryl or heteroaryl substituent group can be optionally substituted with up to 5 substituents, which may be the same or different, and are selected from halo, —OH, alkyl, —C(O)OR 6 , —N(R 6 ) 2 , —NHC(O)R 6 , —C(O)N(R 6 ) 2 , —S(O) 2 R 7 , —CN, —OH, —NO 2 , and —O-alkyl; and wherein any aryl, cycloalkyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl group can be optionally fused to an aryl, cycloalkyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl group; each occurrence of R 2 is independently H, alkyl, haloalkyl, hydroxyalkyl, -(alkylene) m -C(O)N(R 6 ) 2 , -(alkylene) m -NHC(O)R 6 or -(alkylene) m -N(R 6 ) 2 ; R 3 is H, alkyl, haloalkyl, hydroxyalkyl, -(alkylene) m -C(O)N(R 6 ) 2 , -(alkylene) m -NHC(O)—R 6 or -(alkylene) m -N(R 6 ) 2 ; R 3a is H, alkyl, haloalkyl, hydroxyalkyl, -(alkylene) m -C(O)N(R 6 ) 2 , -(alkylene) m -NHC(O)—R 6 or -(alkylene) m -N(R 6 ) 2 ; each occurrence of R 5 is independently H, alkyl, -(alkylene) m -aryl, -(alkylene) m -heteroaryl, -(alkylene) m -heterocycloalkyl, -(alkylene) m -N(R 6 ) 2 , -(alkylene) m -OH, -(alkylene) m -NHC(O)R 6 , hydroxyalkyl, haloalkyl, —C(O)R 6 , —C(O)OR 6 , —C(O)-(alkylene) m -N(R 6 ) 2 , -(alkylene) m -NHC(O)R 6 , —NHC(O)OR 6 or —NHS(O) 2 R 7 ; each occurrence of R 6 is independently H, alkyl, haloalkyl, cycloalkyl, aryl, heterocycloalkyl or heteroaryl; each occurrence of R 7 is independently H, alkyl, aryl, cycloalkyl or haloalkyl; R 8 is H, alkyl, —OH, —O-alkyl or haloalkyl; R 10 is H, alkyl, haloalkyl, hydroxyalkyl, -(alkylene) m -C(O)N(R 6 ) 2 , -(alkylene) m -NHC(O)R 6 or -(alkylene) m -N(R 6 ) 2 ; R 10a is H, alkyl, haloalkyl, hydroxyalkyl, -(alkylene) m -C(O)N(R 6 ) 2 , -(alkylene) m -NHC(O)—R 6 or -(alkylene) m -N(R 6 ) 2 ; each occurrence of R 11 is independently H, alkyl, haloalkyl, hydroxyalkyl, -(alkylene) m -C(O)N(R 6 ) 2 , -(alkylene) m -NHC(O)—R 6 or -(alkylene) m -N(R 6 ) 2 ; W is —C(R 5 ) 2 ; Y is H, halo, alkyl or —CN; and each occurrence of m is independently 0 or 1.