Patent ID: 8349330

Claim:
A method of treating multiple myeloma, comprising the step of administering to a patient in need thereof a therapeutically effective amount of a combination of: (a) a monoclonal anti-CS1 antibody or an anti-CS1 antigen binding fragment, wherein said monoclonal anti-CS1 antibody or anti-CS1 antigen binding fragment binds to a protein encoded by SEQ ID NO:1 and comprises (i) a heavy chain variable region with complementarity determining region (CDR) sequences having amino acid sequences of SEQ ID NO:15, SEQ ID NO:16 or SEQ ID NO:87, and SEQ ID NO:17; and (ii) a light chain variable region with CDR sequences having amino acid sequences of SEQ ID NO:18, SEQ ID NO:19, and SEQ ID NO:20; and (b) velcade.