Patent ID: 8748594

Claim:
A process for the preparation of topiramate or a pharmaceutically acceptable salt thereof, wherein the process comprises the following steps: Aa) reacting 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose with sulfurylchloride in xylene or a mixture of xylenes as a first organic solvent in the presence of an organic or inorganic base to form 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfuryl chloride, Ab) washing the mixture obtained in step Aa) at least once with a first aqueous washing agent; Ac) collecting the organic layer of the mixture obtained in step Ab); Ad) drying the organic layer obtained in step Ac with a drying agent; B) adding a second organic solvent to the dried organic layer obtained in step Ad), wherein the second organic solvent has a lower boiling point compared to the boiling point of xylene, and C) reacting the mixture obtained in step B) with ammonia to form topiramate.