Patent ID: 7250399

Claim:
A method of promoting the release and elevation of blood growth hormone levels by administering a compound having the formula A 1″ -Y, wherein A 1″ is Aib, inip, ABU, βAla, His, Sar or any of their respective D-isomers; Y is A 2′ -A 3 -A 4 -A 5 -A 6 -Z′; A 2′ -A 3 -A 4 -A 5 -Z′ or A 2′ -A 3 -A 4 -Z′; wherein A 2′ is A 5 -A 2″ or A 2″ ; wherein A 5 is a spacer amino acid; A 2″ is any natural L-amino acid, Pal, or their respective D-isomers, DαNal or DβNal; A 3 , A 4 and A 5 are any natural L-amino acid, Pal, αNal, βNal, Nle, Arg-DPro, DPCl, D or L cyclohexyl-amino acid, or any of their respective D-isomers; and Z′ is NH 2 , OH, C 1 -C 10 alkylamino, di(C 1 -C 10 alkyl) amino, amino-C 1 -C 10 alkylamino or di(amino C 1 -C 10 alkyl) amino; or pharmaceutically acceptable salts thereof; or a compound having the formula A 1 -A 2 -X, wherein A 1 is Aib, inip or ABU; A 2 is any natural L-amino acid or Pal, or their respective D-isomers, DαNal or DβNal; and X is (1) R 1 -R 2 -Z, wherein R 1 and R 2 are any natural L-amino acid, Pal, αNal, βNal, DpCl, CHx, where CH x is cyclohexyl, CHxAla, or any of their respective D-isomers; and Z is CONH 2 or COOH; (2) DpR 3 Phe-R 4 -Z, wherein R 3 is a halogen; R 4 is L-amino acid or Pal, or their respective D-isomers; and Z is CONH 2 or COOH; (3) NH(CH 2 ) n NH, where n is 1 to 8; (4) R 5 -R 6 , wherein R 5 is any natural L-amino acid, Pal, αNal, βNal, DpCl, CHx, or any of their respective D-isomers; and R 6 is diisobutylamide, dipropylamide, butylamide, pentylamide, dipentylamide, or C(=0)(substituted heteroalicyclic or heteroaromatic); (5) DTrp Phe ArgR 7 , wherein R 7 is NH(CH 2 ) n NH, where n is 1 to 8; or (6) R 8 -R 9 -R 10 -Z, wherein R 8 is DTrp, DPro, DαNal or DβNal; R 9 is any natural L-amino acid or Pal, or their respective D-isomers; R 10 is any natural L-amino acid or Pal, or their respective D-isomers; and Z is CONH 2 or COOH; or pharmaceutically acceptable salts thereof; or of the formula A 1′ -X′, wherein A 1′ is Aib, inip, ABU, IMC, Ava, 4-IMA, βAla, Ileu, Trp, His, DpCl, CHx where CH x is cyclohexyl, or any of their respective D-isomers; and X′ is (1) R 1 -R 2 -Z′, wherein R 1 is any natural L-amino acid or Pal, or their respective D-isomers, DαNal or DβNal; and R2 is any natural L-amino acid, Pal, αNal, βNal, DpCl, Aib, CHx, or CHxAla, or any of their respective D-isomers; and Z is CONH 2 or COOH; or (2) R 3 -R 4 , wherein R 3 is any natural L-amino acid or Pal, or their respective D-isomers, DαNal or DβNal; and R 4 is NH(CH 2 ) n NH, where n is 1 to 8; or pharmaceutically acceptable salts thereof in an effective amount with a second compound, wherein the second compound is a compound which acts as an agonist at the growth hormone releasing hormone receptor or inhibits the release of somatostatin.