Patent ID: 7803372

Claim:
A composition comprising: a) a naked humanized MN-14 (hMN-14) antibody comprising light chain variable region CDR sequences CDR1 (KASQDVGTSVA, SEQ ID NO: 20); CDR2 (WTSTRHT, SEQ ID NO: 21); and CDR3 (QQYSLYRS, SEQ ID NO: 22); and heavy chain variable region CDR sequences CDR1 (TYWMS, SEQ ID NO: 23); CDR2 (EIHPDSSTINYAPSLKD, SEQ ID NO: 24); and CDR3 (LYFGFPWFAY, SEQ ID NO: 25) and human framework region sequences and an IgG1 human constant region, wherein administration of the naked hMN-14 antibody to a cancer expressing CEA sensitizes the cancer to administration of an apoptosis agent selected from the group consisting of DTIC and CPT-11; and b) an apoptosis agent selected from the group consisting of DTIC and CPT-11, wherein the combination of the naked hMN-14 antibody and the apoptosis agent is more effective for treatment of human medullary thyroid carcinoma or human colorectal cancer than either the naked anti-CEA MAb or the apoptosis agent alone or the sum of the effects of the naked anti-CEA MAb and the apoptosis agent administered individually.