Patent ID: 7615553

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0, 1, 2 or 3 and when n is 0 then a direct bond is intended; each Q is each X is nitrogen; each Y is nitrogen; each Z is nitrogen or R 1 is —C(O)NH(OH) or —NHC(O)C 1-6 alkanediylSH; R 2 is hydrogen, halo, hydroxy, amino, nitro, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, di(C 1-6 alkyl)amino, hydroxyamino or naphtalenylsulfonylpyrazinyl; R 3 is hydrogen, C 1-6 alkyl, arylC 2-6 alkenediyl, furanylcarbonyl, naphthalenylcarbonyl, —C(O)phenylR 9 , C 1-6 alkylaminocarbonyl, aminosulfonyl, arylaminosulfonyl, aminosulfonylamino, di(C 1-6 alkyl)aminosulfonylamino, arylaminosulfonylamino, aminosulfonylaminoC 1-6 alkyl, di(C 1-6 alkyl)aminosulfonylaminoC 1-6 alkyl, arylaminosulfonylaminoC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-12 alkylsulfonyl, di(C 1-6 alkyl)aminosulfonyl, trihaloC 1-6 alkylsulfonyl, di(aryl)C 1-6 alkylcarbonyl, thiophenylC 1-6 alkylcarbonyl, pyridinylcarbonyl or arylC 1-6 alkylcarbonyl wherein each R 9 is independently selected from phenyl; phenyl substituted with one, two or three substituents independently selected from halo, amino, C 1-6 alkyl, C 1-6 alkyloxy, hydroxyC 1-4 alkyl, hydroxyC 1-4 alkyloxy, aminoC 1-4 alkyloxy, di(C 1-4 alkyl)aminoC 1-4 alkyloxy, di(C 1-6 alkyl)aminoC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl, hydroxyC 1-4 alkylpiperazinylC 1-4 alkyl, C 1-4 alkyloxypiperidinylC 1-4 alkyl, hydroxyC 1-4 alkyloxyC 1-4 alkylpiperazinyl, C 1-4 alkylpiperazinylC 1-4 alkyl, di(hydroxyC 1-4 alkyl)aminoC 1-4 alkyl, pyrrolidinylC 1-4 alkyloxy, morpholinylC 1-4 alkyloxy, or morpholinylC 1-4 alkyl; thiophenyl; or thiophenyl substituted with di(C 1-4 alkyl)aminoC 1-4 alkyloxy, di(C 1-6 alkyl)aminoC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl, pyrrolidinylC 1-4 alkyloxy, C 1-4 alkylpiperazinylC 1-4 alkyl, di(hydroxyC 1-4 alkyl)aminoC 1-4 alkyl or morpholinylC 1-4 alkyloxy; R 4 is hydrogen, hydroxy, amino, hydroxyC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkyloxy, arylC 1-6 alkyl, aminocarbonyl, hydroxycarbonyl, aminoC 1-6 alkyl, aminocarbonylC 1-6 alkyl, hydroxycarbonylC 1-6 alkyl, hydroxyaminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylaminoC 1-6 alkyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; when R 3 and R 4 are present on the same carbon atom, R 3 and R 4 together may form a bivalent radical of formula —C(O)—NH—CH 2 —NR 10 —(a-1) wherein R 10 is hydrogen or aryl; when R 3 and R 4 are present on adjacent carbon atoms, R 3 and R 4 together may form a bivalent radical of formula ═CH—CH═CH—CH═ (b-1); aryl in the above is phenyl, or phenyl substituted with one or more substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, cyano or hydroxycarbonyl.