Patent ID: 6946542

Claim:
A method for preparing a peptide, the method comprising: providing an amino derivative of formula 6 wherein: R 1 , R 2 and R 4 are independently selected from a group consisting of hydrogen, alkyl, allyl, alkenyl, aryl, heteroaryl, acyl, sulfonyl, amino, alkylamino, dialkylamino, acylamino, sulfonylamino, and alkoxy, provided that two or more of R 1 , and R 2 R 4 can be connected together forming one or more rings; R 3 is alkyl, aryl, heteroaryl, allyl, alkenyl, alkynyl or allenyl; and Rw is hydrogen, alkyl, aryl, heteroaryl; converting the amino amide derivative of formula 6 to a compound of formula 7 wherein: Rw′ is hydrogen, alkyl, aryl, heteroaryl; contacting the compound of formula 7 with an amine of formula 8 and an organoboron compound of formula 9 to form a reaction mixture wherein: R 5 is alkyl, aryl, heteroaryl, allyl, alkenyl, alkynyl, or allenyl; Rc and Rd are independently selected from a group consisting of hydrogen, alkyl, allyl, benzyl, aryl, heteroaryl, acyl, sulfonyl, amino, acylamino, sulfonylamino, and alkoxy, provided that Rc and Rd can be joined together forming a ring; and X and Y are independently selected from a group consisting of hydroxy, alkoxy, aryloxy, amino, alkylamino, and dialkylamino, provided that X and Y can also be joined together forming a ring; and allowing the reaction mixture to react to form a peptide of formula 10