Patent ID: 7332272

Claim:
A method for identifying analytes that induce a third expression profile that is more similar to a first expression profile than is a second expression profile, comprising: (a) performing an assay to obtain a first expression profile of a set of representative molecules in a first biological sample; (b) performing an assay to obtain a second expression profile of the set of molecules in a second biological sample, wherein the second biological sample differs from the first biological sample by a known parameter; (c) performing an assay to obtain a third expression profile of the set of molecules in the second biological sample after treatment of the second biological sample with at least one analyte of previously uncharacterized specific pharmacological activity; and (d) comparing the third expression profile with the first and second expression profiles to identify one or more analytes that induces a third expression profile that is more similar to the first expression profile than is the second expression profile, wherein the analytes identified as inducing a third expression profile that is more similar to the first expression profile than is a second expression profile is indicative of the identified analytes possessing pharmacological activity.