Patent ID: 8058304

Claim:
A merged compound of the formula (IXXXa): wherein: indicates a bond that gives rise to either R or S stereochemistry; R 1a is hydrogen; R 2a is an aryloxypropanolamine side chain of a Î² 1 -blocker or a substituted propanol-3-yl, wherein the substituted propanol-3-yl is substituted at one or more position with a group selected from hydroxyl, phenyl, or substituted phenyl wherein the substituted phenyl is substituted with C 1 -C 8 alkyloxylalkyl group; and R 21 and R 22 are independently selected from a substituted or unsubstituted C 1 -C 8 alkoxy group wherein the substituted C 1 -C 8 alkoxy is substituted with a hydroxyl and/or a substituted or unsubstituted amino group; as isolated enantiomeric, diastereomeric and geometric isomers thereof, and mixtures thereof.