Patent ID: 8454964

Claim:
A medicament for allergen-specific immunotherapy, said medicament containing a therapeutically effective amount of microparticles in a pharmaceutical formulation suitable for in vivo administration selected from the group consisting of an injectable solution, rectal foam, nasal spray, ointment and plaster, said microparticles consisting of: (a) a three dimensionally cross-linked agarose bead; and (b) at least one purified recombinant polypeptide allergen derived from plant pollen bound to said bead by means of a covalent bond between said cross-linked agarose and a reactive group of said allergen, wherein said medicament is capable of inducing a strong allergen-specific IgG response comparable to that of an equivalent Alum-bound allergen with less granulomatous tissue reactions as compared to said Alum-bound allergen, further wherein the microparticles have a mean diameter that ranges from 0.1 μm to 10 μm.