Patent ID: 8575145

Claim:
A compound of general Formula I: or a pharmaceutically acceptable salt thereof, wherein: A is OR 10 or NR 11 R 12 ; B is H, F, Cl, OR a , (1-6C alkyl)NR b R c , (1-6C alkyl)OH, CH(OH)CH 2 OH, or (1-4C alkyl); R 1 is H, F, Cl, Br, Me, cyclopropyl or CN; R 1a , R 2 , R 3 and R 4 are independently H, F, Cl, Br, Me or CN; R 5 and R 7 are independently H, F, Me or CN; R 6 is H, F, Me, Br, CN, cyclopropyl, phenyl, MeO— or MeOCH 2 CH 2 O—; R 10 is H, hetCyc 1 , -(1-3C alkyl)hetCyc 1a , hetCyc 2 , (CR 17 R 18 ) p (CR 13 R 14 )CH 2 NR 15 R 16 , —(CR 17 R 18 ) p (CR 13 R 14 )CH 2 OH, (1-6C alkyl), hetAr 1 , (1-3C alkyl)hetAr 1a , or (3-7C)cycloalkyl substituted with NH 2 , NH(1-6C alkyl) or N(1-6C alkyl) 2 ; R 11 is H or (1-6C)alkyl; R 12 is hetCyc 3 , (1-6C alkyl)NR 15 R 16 , C(O)(1-6C alkyl)NR 15 R 16 , (1-6C alkyl)NHC(O)O(1-6C alkyl), or (4-7C)cycloalkyl optionally substituted with OH, NH 2 , NH(1-6C alkyl) or N(1-6C alkyl) 2 ; R 13 is H, (1-6C)alkyl, F or OH, and R 14 is H, (1-6C)alkyl or F, or R 13 and R 14 together with the carbon atom to which they are attached form a 3-6 membered carbocyclic ring; each R 15 , R 16 , R 17 and R 18 is independently H or (1-6C) alkyl, or each R 15 , R 17 and R 18 is independently H or (1-6C)alkyl and R 16 is H, (1-6C)alkyl, C(═O)CH 2 F, CH 2 CHF 2 or CH 2 CF 3 ; or NR 15 R 16 forms a 5-6 membered heterocyclic ring having a first ring heteroatom which is N and optionally having a second ring heteroatom selected from N and O; hetCyc 1 , hetCyc 1a , and hetCyc 3 are independently a 4-7 membered heterocycle having a ring nitrogen atom and optionally substituted with one or more R 9 groups, or hetCyc 1 and hetCyc 3 are independently a 4-7 membered heterocycle having a ring nitrogen atom and optionally substituted with one or more R 9 groups, and hetCyc 1a is selected from a morpholinyl and 4-7 membered azacyclic ring optionally substituted with one or more R 9 groups; each R 9 is independently selected from halogen, (1-6C)alkyl, cyclopropylmethyl, benzyl, NR f R g , -(1-6C alkyl)NR h R i , OR j , (1-6C alkyl)OR k , (1-6C)fluoroalkyl, C(O)NR m R n , (1-6C alkyl)C(O)NR p R q , and C(O)O(1-6C alkyl); hetCyc 2 is an 8-membered bridged heterocycle having a ring nitrogen atom; hetAr 1 and hetAr 1a are independently a 5 or 6 membered heteroaryl having 1-2 ring nitrogen atoms and optionally substituted with one or more substituents independently selected from F, Cl, Br, Me, cyclopropyl, CN, NH 2 , NH(1-6C alkyl) and N(1-6C alkyl) 2 ; R a is H, (1-6C alkyl), -(1-6C alkyl)-O-(1-6C alkyl) or -(1-6C alkyl)-O-(3-6C cycloalkyl); each R b , R c , R f , R g , R h , R i , R k , R m , R p and R q is independently selected from H and (1-6C alkyl); R j is H, (1-6C alkyl) or cyclopropyl; R n is H, (1-6C alkyl), —O(1-6C alkyl) or —O(3-6C cycloalkyl); and p is 0, 1 or 2.