Patent ID: 8906681

Claim:
A chimeric therapeutic polypeptide of a pre-existing therapeutic antibody, said pre-existing therapeutic antibody exhibiting a secondary structure that comprises at least one tight turn containing a sequence of four to about seven amino acid residues in which at least two amino acid side chains extend on the same side of the tight turn and are within less than about 7 Å of each other, said preexisting therapeutic antibody lacking the sequon within that sequence of four to about seven amino acid residues, in the direction from left to right and from N-terminus to C-terminus, Aro-(Xxx)n-(Zzz)p-Asn-Yyy-Thr/Ser, (SEQ ID NO:001) wherein Aro is an aromatic amino acid residue, n is zero, 1, 2, 3 or 4, Xxx is an amino acid residue other than an aromatic residue, P is zero or 1, Zzz is any amino acid residue, Asn is asparagine, Yyy is any amino acid residue other than proline, and Thr/Ser is one or the other of the amino acid residues threonine and serine, said chimeric therapeutic polypeptide having substantially the same length, at least one tight turn and substantially the same sequence as the pre-existing therapeutic polypeptide, the two sequences differing by the presence in the chimeric therapeutic polypeptide of said sequon, Aro-(Xxx)n-(Zzz)p-Asn-Yyy-Thr/Ser (SEQ ID NO:001), and said sequon being located at the same position in said tight turn as said sequence of four to about seven amino acid residues such that the side chains of the Aro, Asn and Thr/Ser amino acid residues project on the same side of the turn and are within less than about 7 Å of each other.