Patent ID: 7378400

Claim:
A therapeutic method for treating an inflammatory response caused by autoimmune stimulation, comprising the administration to a patient in need thereof of an antiinflammatory amount of an A 2A adenosine receptor agonist, wherein the A 2A adenosine receptor agonist is a compound having formula (I): wherein Z is CR 3 R 4 R 5 ; each R 1 is independently hydrogen; each R 2 is independently hydrogen; R 4 and R 5 together with the atoms to which they are attached form a saturated mono- or bicyclic cycloalkyl ring having 3, 4, 5, 6, 7, 8, 9 or 10 ring atoms wherein the cycloalkyl optionally comprises 1-2 N, O, or S; wherein any ring comprising R 4 and R 5 is substituted with from 1 to 3 R 6 groups; wherein each R 6 is independently (C 1 -C 6 )alkyl, CH 2 OH, —CO 2 R a , R a C(═O)O—, or R b R c NC (═O); R 3 is hydrogen; each R 7 is independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, phenyl or phenyl (C 1 -C 6 )alkylene; X is CH 2 OH, —CO 2 R a , —CH 2 OC(O)R a , or —C(O)NR b R c ; wherein any alkyl group of R 6 is optionally substituted on carbon with one or more substituents selected from the group consisting of CH 2 OH, —CO 2 R a , R a C(═O)O—, R a C(═O)—, and R b R c NC(═O)—; wherein each R a , R b and R c is independently hydrogen, (C 1 -C 6 )alkyl, or (C 1 -C 6 )alkyl substituted with 1-3(C 1 -C 6 )alkoxy, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkylthio, aryl, or aryl(C 1 -C 6 )alkylene; m is 0 to 6; or a pharmaceutically acceptable salt thereof.