Patent ID: 7345070

Claim:
A compound represented by the following structural formula: or a pharmaceutically acceptable salt and hydrate thereof, wherein: (a) R1 is a non-heterocyclic group selected from the group consisting of aryl, cycloalkyl, aryl-C1-C4 alkyl, cycloalkyl-C1-C4 alkyl, and t-butyl, wherein the aryl and cycloalkyl groups are each optionally substituted with substituents selected from the group consisting of halo, carboxyl, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, nitro, cyano, CHO, hydroxyl, C1-C4 alkanoic acid and —C(O)NR13R13 in which each R13, independently, H or a C1-C4 alkyl; (b) R2 is selected from the group consisting of H, C1-C4 alkyl, C1-C4 haloalkyl and phenyl; (c) n is 2, 3, or 4; (d) W is selected from the group consisting of CH 2 , CH(OH), C(O) and O; (e) Y is an unsubstituted or substituted group selected from the group consisting of thiophen-2,5-diyl and phenylene wherein the thiophen-2,5-diyl substituents are selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl and C1-C4 haloalkoxy; (f) R3 is a C1-C4 alkyl or C1-C4 haloalkyl; (g) R4 is selected from the group consisting of a substituted or unsubstituted phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, and benzo[1,3]dioxol-5-yl group, wherein the substituents are selected from the group consisting of halo, carboxyl, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, nitro, cyano, CHO, hydroxyl, C1-C4 alkanoic acid and —C(O)NR13R13 in which each R13, independently, H or a C1-C4 alkyl; and (h) R5 is selected from the group consisting of H, C1-C4 alkyl, and aminoalkyl.