Patent ID: 7071335

Claim:
A compound of formula: or a pharmaceutically acceptable salt thereof, wherein: X is O or S; R 1 is methyl or halo; R 2 is: (a) —(C 2 –C 6 )alkyl, —(C 2 –C 3 )alkenyl, —CH 3 , —CH 2 F, or —CHF 2 , which is substituted with one or more of —NO 2 , —CH═NR 6 , or —NR 6 OH; or (b) —(CH 2 ) m C(O)R 6 , —(CH 2 ) m OR 6 , or —(CH 2 ) m SR 6 , which is unsubstituted or substituted with one or more of —CN, —OH, -halo, —NO 2 , —CH═NR 6 , or —NR 6 OH; R 3 is: (a) —(C 1 –C 6 )alkyl, —(C 2 –C 6 )alkenyl, —(C 2 –C 6 )alkynyl, —(CH 2 ) n OR 6 , which is unsubstituted or substituted with one or more of —CN, —OH, -halo, —NO 2 , —CH═NR 6 , or —NR 6 OH; or (b) —H, -halo, —NO 2 , —CN, or —NH 2 ; R 4 is —H; R 5 is: (a) —(C 2 –C 6 )alkenyl, or —(C 2 –C 6 )alkynyl; or (b) —(C 3 –C 8 )cycloalkyl, —(C 5 –C 8 )cycloalkenyl, —(C 6 )aryl, —(C 10 )aryl, —(C 14 )aryl, —(C 3 –C 7 )heterocycle, —(C 1 –C 6 )alkyl(C 6 )aryl, —(C 1 –C 6 )alkyl(C 10 )aryl, —(C 1 –C 6 )alkyl(C 14 )aryl, —(C 1 –C 6 )alkyl(C 3 –C 7 )heterocycle, —(C 2 –C 6 )alkenyl(C 6 )aryl, —(C 2 –C 6 )alkenyl(C 10 )aryl, —(C 2 –C 6 )alkenyl(C 14 )aryl, —(C 2 –C 6 )alkenyl(C 3 –C 7 )heterocycle, —(C 2 –C 6 )alkynyl(C 3 –C 8 )cycloalkyl, —(C 2 –C 6 )alkynyl(C 5 –C 8 )cycloalkenyl, —(C 2 –C 6 )alkynyl(C 6 )aryl, —(C 2 –C 6 )alkynyl(C 10 )aryl, —(C 2 –C 6 )alkynyl(C 14 )aryl, or —(C 2 –C 6 )alkynyl(C 3 –C 7 )heterocycle, which is unsubstituted or substituted with one or more R 7 groups; each R 6 is independently —H, —(C 1 –C 6 )alkyl, —(C 2 –C 6 )alkenyl, —(C 2 –C 6 )alkynyl, —(C 3 –C 8 )cycloalkyl, —(C 5 –C 8 )cycloalkenyl, —(C 6 )aryl, —(C 3 –C 5 )heterocycle, —C(halo) 3 , or —CH(halo) 2 ; each R 7 is independently —(C 1 –C 6 )alkyl, —(C 2 –C 6 )alkenyl, —(C 2 –C 6 )alkynyl, —(CH 2 ) n (C 3 –C 8 )cycloalkyl, —(CH 2 ) n (C 5 –C 8 )cycloalkenyl, —(CH 2 ) n (C 6 )aryl, —(CH 2 ) n SR 6 , —(CH 2 ) n CH(halo) 2 , —(CH 2 ) n C(halo) 3 , -halo, or —(CH 2 ) n OR 6 ; m is 1 or 2; and n is an integer ranging from 0 to 2.