Patent ID: 6852713

Claim:
A compound of Formula I: wherein: A and B are each H, or when taken together with the carbon atoms to which they are attached, form a carbon—carbon double bond; X is —O— or a single bond; Y is —O—, —CH 2 —, or a single bond, provided that when X is —O—, Y cannot be —O—; Z is H or —OH; R 1 is optionally substituted alkyl, optionally substituted aralkyl, or optionally substituted aryl; R 2 is optionally substituted alkyl, optionally substituted aryl, or —NR 3 R 4 provided that when Y is —O—, R 2 cannot be —NR 3 R 4 ; m and n are each independently an integer from 1 to 4, and the sum of (m+n) is an integer from 2 to 5; p is the integer 1 or 2; R 3 is H or optionally substituted alkyl; R 4 is —C(═O)R 5 , —C(═O)NR 5 R 6 , —SO 2 R 5 , —C(═O)NHR 6 , optionally substituted aryl, or an optionally substituted mono- or multi-cyclic aromatic ring system having from 1 to 50 ring carbon atoms and 1 to 4 ring heteroatoms selected from the group consisting of O, N, and S; R 5 is optionally substituted alkyl, optionally substituted cycloalkyl, an optionally substituted mono- or multi-cyclic aliphatic ring system having from 3 to 20 ring carbon atoms and 1 to 4 rine heteroatoms selected from the group consisting of O, N, and S, optionally substituted aralkyl, optionally substituted aryl, or an optionally substituted mono- or multi-cyclic aromatic ring system having from 1 to 50 ring carbon atoms and 1 to 4 ring heteroatoms selected from the group consisting of O, N, and S; and R 6 is H, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, or together with the nitrogen atom to which they are attached, R 5 and R 6 form a 4-8 membered optionally substituted heterocycloalkyl ring, said heterocycloalkyl ring optionally interrupted by one or more additional heteroatoms selected from nitrogen, oxygen, and sulfur; or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or N-oxide thereof; wherein said optional substituents are selected from the group consisting of halo, alkyl, cycloalkyl, alkylcycloalkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl, heteroaralkyl, spiroalkyl, heterocycloalkyl, hydroxyl (—OH), alkoxyl, aryloxyl, aralkoxyl, nitro (—NO 2 ), cyano (—CN), amino (—NH 2 ), -N-substituted amino (—NHR″), -N,N-disubstituted amino (—N(R″)R″), carboxyl (—COOH), —C(═O)R″, —OR″, —C(═O)OR″, —NHC(═O)R″, aminocarbonyl (—C(═O)NH 2 , -N-substituted aminocarbonyl (—C(═O)NHR″), -N,N-disubstituted aminocarbonyl (—C(═O)N(R″)R″), thiol, thiolato (SR″), sulfonic acid (SO 3 H), phosphonic acid (PO 3 H), S(═O) 2 R″, S(═O) 2 NH 2 , S(═O) 2 NHR″, S(═O) 2 NR″R″, NHS(═O) 2 R″, NR″S(═O) 2 R″, CF 3 , CF 2 CF 3 , NHC(═O)NHR″, NHC(═O)NR″R″, NR″C(═O)NHR″, NR″C(═O)NR″R″, and NR″C(═O)R″, wherein each R″ is independently H, alkyl, cycloalkyl, alkenyl, aryl, aralkyl, heteroaryl, or heterocycloalkyl.