Patent ID: 7053069

Claim:
A pharmaceutical composition comprising: a) a C-21 modified epothilone compound of formula I: wherein: P-Q is a C,C double bond or an epoxide; G is R is selected from the group consisting of H, alkyl, and substituted alkyl; R 1 is selected from the group consisting of G 1 is selected from the group consisting of H, halogen, CN, alkyl and substituted alkyl; G 2 is selected from the group consisting of H, alkyl, and substituted alkyl; G 3 is selected from the group consisting of O, S, and NZ 1 ; G 4 selected from the group consisting of H, alkyl, substituted alkyl, OZ 2 , NZ 2 Z 3 , Z 2 C═O, Z 4 SO 2 , and optionally substituted glycosyl; G 5 is selected from the group consisting of halogen, N 3 , NCS, SH, CN, NC, N(Z 1 ) 3 + and heteroaryl; G 6 is selected from the group consisting of H, alkyl, substituted alkyl, CF 3 , OZ 5 , SZ 5 , and NZ 5 Z 6 ; G 7 is CZ 7 or N; G 8 is selected from the group consisting of H, halogen, alkyl, substituted alkyl, OZ 10 , SZ 10 , and NZ 10 Z 11 ; G 9 selected from the group consisting of O, S, —NH—NH— and —N═N—; G 10 is N or CZ 12 ; G 11 is selected from the group consisting of H 2 N, substituted H 2 N, alkyl, substituted alkyl, aryl, and substituted aryl; Z 1 , Z 6 , Z 9 , and Z 11 are independently selected from the group consisting of H, alkyl, substituted alkyl, acyl, and substituted acyl; Z 2 is selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, and heterocyclic; Z 3 , Z 5 , Z 8 , and Z 10 are independently selected from the group consisting of H, alkyl, substituted alkyl, acyl, substituted acyl, aryl, and substituted aryl; Z 4 is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, and heterocyclic; Z 7 is selected from the group consisting of H, halogen, alkyl, substituted alkyl, aryl, substituted aryl, OZ 8 , SZ 8 , and NZ 8 Z 9 ; and Z 12 is selected from the group consisting of H, halogen, alkyl, substituted alkyl, aryl, and substituted aryl; with the proviso that when R 1 is G 1 , G 2 , G 3 and G 4 cannot simultaneously have the following meanings: G 1 and G 2 =H, G 3 =O and G 4 =H or Z 2 C═O where Z 2 =alkyl, and with the proviso that when R 2 is G 1 , G 2 or G 5 cannot simultaneously have the following meanings: G 1 and G 2 =H, and G 5 =F; or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof; b) a dibasic carboxylic acid; and c) a dextran polymer.