Patent ID: 8268865

Claim:
A compound having the structure of formula I: or a pharmaceutically acceptable salt or pro-drug thereof wherein; each bond represented by a dashed and solid line represents a bond selected from the group consisting of a single bond and a double bond; each R 1 is independently selected from C 3 -C 6 carbocyclyl, aryl and heteroaryl, each optionally substituted with up to 3 substituents independently selected from the group consisting of halo, C 1 -C 6 alkyl, carbocyclyl, —(CH 2 ) n aryl, —OR 2 , —OR 14 , —S(R 2 ) 2 , —SO 2 NHR 14 , —(CH 2 ) n SH, —CF 3 , —OCF 3 , —N(R 2 ) 2 , —NO 2 , —CN, —CO 2 alkyl, and —CO 2 aryl; each R 2 is independently selected from H and C 1 -C 6 alkyl; R 3 is —(CH 2 ) n CHR 6 R 7 ; each R 4 is independently selected from —(CH 2 ) m R 9 , allyl, —(CH 2 ) n CO 2 H—, —(CH 2 ) n CONH 2 and —(CH 2 ) n CHR 6 R 7 ; each R 5 is independently selected from —(CH 2 ) m R 9 , —NHR 2 , and —(CH 2 ) n CHR 6 R 7 ; each R 6 is independently selected from H and —(CH 2 ) m NH 2 ; each R 7 is independently selected from —(CH 2 ) m NHR 8 , —(CH 2 ) m NHC(═NH)NH 2 , and —(CH 2 ) m NHC(R 2 )═NH; each R 8 is independently selected from H, C 1 -C 6 alkyl, Alanine, Arginine, Aspartic acid, and Cysteine; each R 9 is independently selected from H, C 1 -C 6 alkyl, SH and OH; R 13 is H, with the proviso that R 13 is directly attached to the nitrogen; R 14 is quinolin, optionally substituted with up to 3 substituents independently selected from the group consisting of a halide, alkyl, carbocyclyl, —(CH 2 ) n R 1 , —OR 2 , —OR 1 , ═O, —S(R 2 ) 2 , —SO 2 NHR 1 , —(CH 2 ) n SH, —CF 3 , —OCF 3 , —N(R 2 ) 2 , —NO 2 , —CN, —(C═X)R 1 , —(C═X)R 2 , —CO 2 alkyl, and —CO 2 aryl, with the proviso that R 14 is directly attached to the nitrogen; A 1 is —(CH 2 ) m — or —[C(R 2 R 9 )] m —; A 2 is —O(CH 2 ) n —; A 3 is H or A 3 is —CH 2 — bonded to R 1 to form a ring; a1, a2, and a3 are independently equal to 0 or 1; D 1 is selected from —CH(NHR 8 )— and —CH(R 2 )—; D 2 , D 3 , and D 4 are independently selected from the group consisting of —(CH 2 ) m —, —CH(R 2 )—, —CH(NHR 8 )—, —N(R 6 )—, —S—, —C(═O)—, and —SO 2 —, D 5 is —(CH 2 ) m —, d1, d2, d3, d4 and d5 are independently equal to 0 or 1; Z 1 is an aryl or carbocyclyl; z1 is 0 or 1; if z1 is 0 then at least two of d1, d2, d3, d4 and d5 are equal to 1; if z1 is 1 then at least one of d1, d2, d3, d4 and d5 is equal to 1; X 1 and X 2 are each hydrogen or taken together are ═O, or X 1 is absent and X 2 is —O— bonded to R 14 to form a 5- or 6-membered heteroaryl, wherein when X 1 is absent, the bond to nitrogen represented by a dashed and solid line is a double bond; each X is independently O or S; each n is independently an integer from 0 to 4; and each m is independently an integer from 1 to 3.