Patent ID: 8600479

Claim:
A catheter system for delivery of a pressurized liquid solution or suspension containing a bioactive agent via a spatially defined catheter implantation into a targeted body tissue comprising a tumor, tumor plaque or tissue adjacent to a surgical tumor resection cavity of a patient; the system comprising: a plurality of biocompatible catheters, each catheter being hollow, and linear, curvilinear, or helical; each catheter being adapted for insertion into the body tissue and for bulk flow or convection-enhanced delivery of the solution or suspension of the bioactive agent through the catheter into the tissue; and the catheter system comprising a catheter guide device comprising a plurality of modular tiles, wherein each tile comprises a plurality of passageways therethrough, each modular tile being adapted for emplacement on a respective portion of a surface of the target tissue for guiding insertion of each of the biocompatible catheters through the respective passageway into the tissue to form a spatially defined catheter implantation; wherein as directed by the catheter guide device each catheter is emplaced within the tissue individually, in subsets of a plurality of catheters, or all of a plurality of catheters concurrently, to provide the spatially defined implantation such that the pressurized solution or suspension of the bioactive agent is delivered through each catheter thereby providing the bulk flow or convection-enhanced delivery within a volume of target tissue; the catheter system further comprising a pressurized liquid supply system adapted for delivery of a pressurized liquid via a manifold to each of the plurality of catheters; wherein the liquid supply system comprises a pressurizer adapted to apply a pressure to a liquid solution and a manifold to deliver the liquid under pressure to each of the plurality of catheters such that the liquid can pass through each catheter into the targeted body tissue.