Patent ID: 8470813

Claim:
A method of treating a disorder or condition selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, Pick's Disease and, dementia associated with Lewy bodies, , in a patient in need of such treatment, comprising administering a therapeutically effective amount of a compound of formula (IIA): or a pharmaceutically acceptable salt, ester or amide thereof, wherein n is 1 or 2; R 1 , is hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein the alkyl group, alkenyl, alkynyl, aryl, and heteroaryl groups are each substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, carboxy, cyano, haloalkoxy, halo, hydroxyl, nitro, and R a R b N—; L is C(O), C(S), S(O), or S(O) 2 ; X is O or S; Z is aryl, cycloalkyl, heteroaryl, heterocycle, R e R f N—, —R 3 or —OR 3 ; R a and R b are each independently hydrogen, alkyl, alkylcarbonyl, arylalkyl, and heteroaryl; R c and R d are each independently hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle, and heterocyclealkyl; R e and R f are each independently hydrogen, alkyl, alkylcarbonyl, alkenyl, alkynyl, aryl, arylalkyl, aryl(hydroxyl)alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocyclealkyl, heteroaryl, heteroaryl(hydroxyl)alkyl, heteroarylalkyl, or hydroxyalkyl, wherein the alkyl group and the alkyl of alkylcarbonyl is substituted with 0, 1, 2 , or 3 substituents selected from alkoxy, cyano, or halo; R 3 is alkyl, alkenyl, alkynyl, arylalkyl, haloalkyl, haloalkenyl, or haloalkynyl; and R 6 is alkyl, alkenyl, formyl, cyano, heteroaryl(hydroxyl)alkyl, or CH═N—(CH 2 ) b —OR g , wherein the alkyl group and the alkenyl group is substituted with 0, 1, 2 , or 3 substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, aryloxy, alkylcarbonyloxy, aryl, arylalkoxy, carboxy, cycloalkyl, cyano, halo, haloalkoxy, heteroaryl, heterocycle, hydroxyl, nitro, and R C R d N—; h is 0, 2, or 3; and R g is hydrogen or alkyl.