Patent ID: 8067405

Claim:
A method for treating AMD, DR, and/or retinal edema in a patient which comprises administering to the patient in need of such treatment a pharmaceutical composition formulated for intraocular, periocular, or retrobulbar injection or perfusion, wherein the composition comprises a pharmaceutically effective amount of a compound of formula I: wherein: A is a pharmaceutically acceptable anion; X 1-4 are independently selected from the group consisting of H, halo, aryl, aralkyl, alkyl, cycloalkyl, aryloxy, free or functionally modified hydroxy, and free or functionally modified amino; Y 1-6 are independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, aralkyl, free or functionally modified hydroxy, and free or functionally modified amino; and Z, Z 1 , and Z 2 together can form a cyclohexane, pyridine, or phenyl ring; or Z is a direct bond, and Z 1 and Z 2 are each a CH 2 group, independently and optionally substituted with aryl, heteroaryl, alkyl, alkoxy, aralkyl, acyl, alkoxycarbonyl, or acyloxy.