Patent ID: 8026382

Claim:
A platinum (IV) compound having efficacy for the treatment of a medical condition, the compound comprising the structure shown in formula I or II: wherein X and Y are, independently, any halogen, —CN, —SCN, —NCS, —NO 2 , —ONO, —OHSO 3 , —OH 2 PO 3 , —OHSO 2 , —SO 3 H, —OH, —OR 2 , —OS(CH 3 ) 2 , —OCOR 2 , —OCOOR 2 , —OSO 2 CH 3 , —SH, —SR 2 , —S 2 CN(R 2 ) 2 , —OSiO 3 , —OBO 2 H, —OHSeO 2 , —NHCOH, —NH 2 CHO,—NH 2 CH 2 OH, —NH 2 C(OH) 3 or —NH 2 CH(OH) 2 or —NHCOR 2 , or X and Y together form a ring structure selected from the group consisting of cyclobutane dicarboxylate (CBDCA) (OCOC 4 H 6 OCO) 2− ; oxalate (C 2 O 4 ) 2− , malanato (OOCCH 2 COO) 2− , dithiocarbamate ((R 2 ) 2 NCS 2 ) − , acetylacetonate (CH 3 COCHCOCH 3 ) − , carboxylate (CO 2 R 2 ) − , sulfate (SO 4 ) 2 , phosphate (HPO 4 ) 2− , selenate (SeO 4 ) 2− , silicate (SiO 4 ) 2− , diborate (B 2 O 5 ) 4− , (acetylacetonate (OCCH 3 CH 2 CH 3 O) − , ethylene diamine (H 2 NC 2 H 4 NH 2 ), bis(diphenylphosphino)ethane (dppe) ((C 6 H 5 ) 2 PC 2 H 4 P(C 6 H 5 ) 2 ), bis(dimethylphosphino)ethane (dmpe) ((CH 3 ) 2 PC 2 H 4 P(CH 3 ) 2 ), 2,2′-bipyridine ((NC 5 H 4 ) 2 ) and glyme (CH 3 OCH 2 CH 2 OCH 3 ); R 1 is —NO 2 , —ONO, —CN, —SCN, —NCS, —COOH, COOR 2 , —CHO, —COR or —SO 3 H; R 2 is folate, N-acetylcysteine, taurine, ethanolamine, safranin, riboflavin, 7-ethoxycoumarin, methylene blue, thiamine hydrochloride, caffeine, N-acetyl galactosamine, naringin, N-acetyl neuraminic acid, methyl alpha-D-mannopyranoside, xanthine, hydantoin, 6-aminonicotinamide, theophylline, N-acetyl glucosamine, alpha-aminoisobutyric acid, cytarabine, pantothenic acid, fluorescein, rhodamine, biotin, inosine, theobromine, histidine, eosin Y, luminol, pyrimidine, thiosalicylic acid, 7-amino-4-methylcoumarin, tris, nicotine, 2,6-dichloro-4-nitropyridine, 2,6-dimethyl-4-nitropyridine, quinoline, pyridoxine, nicotinic acid, pyrimidinecarboxylic acid, imidazole, thiazole, oxazole, succinimidyl ester, pyridine, benzimidazole, benzoxazole, 2-(2-aminophenyl)-benzothiazole, 2-(4-aminophenyl)-benzothiazole, benzothiazole, palmitate, purine, adenine, guanine, hypoxanthine, uric acid, isoguanine, serine, cytosine, thymidine, uracil, myristic acid, oleic acid, succinimide, triethanolamine, diethanolamine, thiazolidinedione, flavin, anthranilic acid, methionine, cysteine, tyrosine, threonine, N-acetyl mannose; R 3 is —NH 3 , —NH 2 R 2 , —NH(R 2 ) 2 , —N(R 2 ) 3 , —NH 2 COR 2 , —NH 2 COH, —NH 2 CHO, —NH 2 CH 2 OH, —NH 2 C(OH) 3 , —NH 2 CH(OH) 2 , —OCH 3 or —OR 2 , or R 3 , R 3 , X, and Y together comprise porphyrin or phthalocyanine; or a pharmaceutically acceptable salt thereof.