Patent ID: 8314124

Claim:
A process for the preparation of a crystalline salt of formula (II) wherein n is an integer of 2 or 3; A n+ is a multivalent metal cation selected from Mg 2+ , Ca 2+ , Mn 2+ , Cu 2+ , Zn 2+ , Al 3+ , and Fe 3+ ; R is a straight or branched C 1 -C 4 -alkyl or -alkenyl or a cyclic C 3 -C 4 -alkyl; R5 is a straight or branched, saturated or unsaturated C 1 -C 4 -alkyl or -alkenyl, a cyclic C 3 -C 4 -alkyl, a straight or branched C 1 -C 4 -alkylthio, a cyclic C 3 -C 4 -alkylthio, a straight or branched C 1 -C 4 -alkylsulfinyl, a cyclic C 3 -C 4 -alkylsulfinyl, fluoro, chloro, bromo, trifluoromethyl or trifluoromethoxy; and R6 is hydrogen; or R5 and R6 taken together are methylenedioxy; R′ is hydrogen, a straight or branched, saturated or unsaturated C 1 -C 4 -alkyl or -alkenyl, a cyclic C 3 -C 4 -alkyl, a straight or branched C 1 -C 4 -alkoxy, a cyclic C 3 -C 4 -alkoxy, fluoro, chloro, bromo or trifluoromethyl; and R″ is hydrogen, fluoro or chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; comprising: reacting a 3-quinolinecarboxamide derivative in neutral form or as a monovalent metal salt, with a salt containing the multivalent metal cation in a liquid phase consisting of water and at least one water miscible organic solvent, in which liquid phase the salt of formula (II) is sparingly soluble.