Patent ID: 8623856

Claim:
A compound represented by Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and, tautomers or a pharmaceutically acceptable salt thereof, wherein: A is optionally substituted C 6-10 aryl, optionally substituted heterocycle, optionally substituted C 3-8 cycloalkyl or optionally substituted C 3-8 cycloalkenyl; B is optionally substituted C 6-10 aryl, optionally substituted heterocycle, optionally substituted C 3-8 cycloalkyl or optionally substituted C 3-8 cycloalkenyl; R 1 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 2 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 3 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 4 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 5 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 6 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 7 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , optionally substituted C 6-10 aryl, optionally substituted heterocycle, optionally substituted C 3-8 cycloakyl, optionally substituted C 3-8 cycloalkenyl, NR 12 R 13 or hydroxyl; R 8 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , optionally substituted C 6-10 aryl, optionally substituted heterocycle, optionally substituted C 3-8 cycloakyl, optionally substituted C 3-8 cycloalkenyl, NR 12 R 13 or hydroxyl; R 9 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , optionally substituted C 6-10 aryl, optionally substituted heterocycle, optionally substituted C 3-8 cycloakyl, optionally substituted C 3-8 cycloalkenyl, NR 12 R 13 or hydroxyl; R 10 is H, halogen, —OC 1-8 alkyl, optionally substituted C 1-8 alkyl, CN, C(O)R 11 , C 6-10 aryl, optionally substituted heterocycle, optionally substituted C cycloakyl, optionally substituted C 3-8 cycloalkenyl, NR 12 R 13 or hydroxyl; L 1 is O, S, NH or CHR 12 ; L 2 is O, S or CHR 12 ; R 11 is H, OH or C 1-8 alkyl; a is 1, 2, 3, 4, 5 or 6; R 12 is H or C 1-8 alkyl; and R 13 is H or C 1-8 alkyl.