Patent ID: 8586549

Claim:
A method for two-phase modulating vaginal flora and vaginal acidity thereby maintaining the pH value of vaginal secretion within a range from 3.5 to 4.5, said method is conducted by promoting Gram-positive bacilli to multiply and produce acids in vagina when the Gram-positive bacilli in vagina are rare and the vaginal acidity is over 4.6, and inhibiting the production of acids in the vagina when the Gram-positive bacilli in vagina are abundant and the vaginal acidity is below 4.0; wherein said method comprises administrating an effective amount of a vaginal composition, said vaginal composition consists of the following components: (1) benzoic acid and/or its sodium salt, together with saccharide(s) as the sole active ingredients; wherein the total amount of benzoic acid and/or its sodium salt, calculated based on sodium benzoate, is 0.1-1.0% (w/v), the total amount of saccharide in the composition is 0.1-20% (w/v); (2) one or more inactive excipient(s) suitable for human vagina; wherein said inactive excipient is a non-flowable, viscous, water-soluble gel matrix, and it is selected from Xanthan gum and polycarbophil; wherein said saccharide is glucose, fructose, mannose, or oligosaccharides or polysaccharides that can be hydrolyzed in vivo or in vitro to produce glucose, fructose and/or mannose, or any mixture of these saccharides, wherein said oligosaccharides or polysaccharides are selected from the group consisting of the following: sucrose, maltose, lactulose, trehalose, cellobiose, melibiose, raffinose, malto-oligosaccharide, isomalto-oligosaccharide, fructo-oligosaccharide, dextrin, starch and glycogen; wherein said vaginal composition is a cleaning-nursing product, a deodorizing agent, a cosmetic, an antimicrobial composition or a pharmaceutical composition, said composition is a non-flowable, viscous, water-soluble gel, said composition does not comprise live bacteria, fungi or other microorganisms; the pH value of the composition is within the range from 4.5 to 7.5.