Patent ID: 7868003

Claim:
A compound of formula I wherein: R1, R2, R3 and R4 are each independently hydrogen, F, Cl, Br, I, CN, NO 2 or R11—(C m H 2m )—A n —; m is zero, 1, 2, 3 or 4; n is zero or 1; R11 is hydrogen, methyl or C p F 2p+1 ; A is oxygen, NH, N(CH 3 ) or S(O) q ; p is 1, 2 or 3; q is zero, 1 or 2; R5 is hydrogen, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or cycloalkyl having 3, 4, 5 or 6 carbon atoms; R6 is hydrogen, OH, F, CF 3 , alkyl having 1, 2, 3 or 4 carbon atoms or cycloalkyl having 3, 4, 5 or 6 carbon atoms; R7 and R8 are each independently hydrogen, F, Cl, Br, CN, CO 2 R12, NR13R14 or R16—(C mm H 2mm )—B nn —; R12 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or cycloalkyl having 3, 4, 5 or 6 carbon atoms; R13 and R14 are each independently hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or cycloalkyl having 3, 4, 5 or 6 carbon atoms; or R13 and R14, which, including the nitrogen atom to which they are bonded, form a 4-, 5-, 6- or 7-membered ring in which one CH 2 group may be replaced by NR15, S or oxygen; R15 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or cycloalkyl having 3, 4, 5 or 6 carbon atoms; mm is zero, 1, 2, 3 or 4; nn is zero or 1; R16 is hydrogen, methyl or C pp F 2pp+1 ; B is oxygen or S(O) qq ; pp is 1, 2 or 3; qq is zero, 1 or 2; W is C r H 2r or C s H 2s−2 ; wherein one or more CH 2 groups in C r H 2r and C s H 2s−2 may be replaced by NR17, oxygen or S; R17 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or cycloalkyl having 3, 4, 5 or 6 carbon atoms; r is 1, 2, 3, 4, 5, 6, 7 or 8; s is 2, 3, 4, 5, 6, 7 or 8; X is —C(O)— or —S(O) 2 —; and Z is —C(O)— or a bond; or a pharmaceutically acceptable salt or trifluoroacetate thereof.