Patent ID: 7652025

Claim:
A method of treating septic shock comprising administering by injection 0.0001 mg to 1g, or administering 0.005 mg to 10 g in an oral formulation, of an opioid κ receptor agonist morphinan derivative represented by the following Formula (I) or a pharmaceutically acceptable acid addition salt thereof to a patient: (wherein represents a double bond or single bond; R 1 is methyl, ethyl, propyl, butyl, isobutyl, cyclopropylmethyl, allyl, benzyl or phenethyl; R 2 and R 3 independently arc hydrogen, hydroxy, acetoxy or methoxy; A represents —NR 4 C(═O)— or —NR 4 C(═O)O— or —NR 4 C(═O)NR 4 (wherein R 4 represents C 1 -C 5 linear or branched alkyl and R 4 s in the formula may be the same or different); B is C 1 -C 3 linear alkylene, —CH═CH—, —C≡C—, —CH 2 —O—, —CH 2 —S— or —CH 2 —NH—; R 5 is hydrogen or an organic group having a skeleton selected from those shown below (wherein Q represents O or S; each of said organic groups may have at least one substituent selected from the group consisting of C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 1 -C 5 alkanoyloxy, hydroxy, fluorine, chlorine, bromine, iodine, amino, nitro, cyano, isothiocyanato, trifluoromethyl, trifluoromethoxy and methylenedioxy); R 6 and R 7 cooperatively represent —O—; and R 8 represents hydrogen).