Patent ID: 8551526

Claim:
A method of producing poorly water soluble drug particles for release comprising the steps of: providing a drug; providing a container comprising aqueous solution; spraying the drug and one or more excipients below the surface level of the aqueous solution wherein the one or more excipients selected from polyoxyethylene sorbitan monolaurate, phosphatidyl choline, a poly(ethylene)-poly(propylene) copolymer, sodium lauryl sulfate (SLS), Poly(vinyl pyrrolidone) (PVP), Poloxamer, polyoxyethylene monostearate, gelation agent, deoxycholic acid, poly(vinyl alcohol) (PVA), cetostearyl alcohol, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, noncrystalline cellulose, magnesium aluminum silicate, and triethanolamine; forming one or more stabilized drug particles by solution precipitation, anti-solvent precipitation, spray freezing, evaporative precipitation or lyophilization; separating said one or more stabilized drug particles from a suspension solution; removing said solution from the one or more stabilized drug particles; and producing one or more stabilized drug particles having a drug-to-excipient ratio of greater than about 4:1 and an average particle diameter from 50 nanometers to about 20 microns; and a dissolution rate greater than about 65% drug in about 60 minutes; wherein the drug-to-excipient ratio is about 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1 or greater; wherein the drug particles have a surface area greater than about 2.5 m 2 /g, 5 m 2 /g, 10 m 2 /g, 20 m 2 /g or 30 m 2 /g; and wherein the drug potency is about 80% or 100%.