Patent ID: 7994121

Claim:
A DPP IV-resistant analog of a biologically active peptide or polypeptide factor, wherein the peptide or polypeptide factor is capable of binding a GLP-1-receptor; the analog of the peptide or polypeptide factor is capable of binding a GLP-1 receptor; the analog of the peptide or polypeptide factor is represented by Xaa-Ala-Yaa-R or Xaa-Pro-Yaa-R; Xaa is an N-terminal amino acid residue; R is GTFTSDVSSYLEGQAAKEFIAWLVKGR (SEQ ID NO: 19), GTFTSDVSSYLEGQAAKEFIAWLVKGRPSSGAPPPS-NH2 (SEQ ID NO: 20), GTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2 (SEQ ID NO: 21), GSFSDEMNTILDNLAARDFINWLIQTKITD (SEQ ID NO: 22), GTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ (SEQ ID NO: 23), KPDNPGEDAPAEDMARYYSALRHYINLITRQRY (SEQ ID NO: 24), EPVYPGDNATPEQMAQYAADLRRY (SEQ ID NO: 25) or KPEAPGEDASPEELNRYYASLRHYLNLVTRQRY (SEQ ID NO: 26); Yaa is an amino acid residue represented by Formula I: R 1 and R 2 are, independently for each occurrence, lower alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxyl, carboxyl, carboxamide, carbonyl, halogen, hydroxyl, amine, or cyano; or R 1 and R 2 taken together form a ring of 4-7 atoms; R 3 is lower alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, amino, alkoxyl, halogen, carboxyl, carboxamide, carbonyl, cyano, thioalkyl, acylamino, amido, cyano, nitro, azido, sulfate, sulfonate, sulfonamido, —(CH 2 ) m R 4 , —(CH 2 ) m OH, —(CH 2 ) m COOH, —(CH 2 ) m O-lower alkyl, —(CH 2 ) m O-lower alkenyl, —(CH 2 ) n O(CH 2 ) m R 4 , —(CH 2 ) m SH, —(CH 2 ) m S-lower alkyl, —(CH 2 ) m S-lower alkenyl, —(CH 2 ) n S(CH 2 ) m R 4 , —(CH 2 ) m NH 2 , —(CH 2 ) m NC(═NH)NH 2 , —(CH 2 ) m C(═O)NH 2 , or —(CH 2 ) m NH 2 ; R 4 is, independently for each occurrence, aryl, aralkyl, cycloalkyl, cycloalkenyl, or heterocyclyl; m is 0, 1, or 2; and n is 0, 1, or 2.