Patent ID: 8586765

Claim:
A process for preparing 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide of the Formula I: said process comprising: (i) reacting acetone cyanohydrin with a solution comprising a compound of Formula VI, and a solvent which is substantially dimethyl sulfoxide (DMSO), thereby forming a compound of Formula VII, wherein, “P” is an acid-labile protecting group and wherein the reaction is catalyzed by up to 0.1× w/w of potassium carbonate; (ii) reacting the reaction mixture obtained from Step (i) with peroxide, thereby forming in situ a compound of Formula VIII, and (iii) reacting the reaction mixture obtained in Step (ii) with an acid, thereby deprotecting the compound of Formula VIII and yielding the compound of the Formula I.