Patent ID: 8809378

Claim:
A method of treating or preventing a metalloenzyme-mediated disease or disorder in or on a plant comprising contacting a compound of Formula I with the plant or seeds: wherein MBG is optionally substituted tetrazolyl, optionally substituted oxazolyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted pyrazolyl; R 1 is halo or haloalkyl; R 2 is H, halo, alkyl, or haloalkyl; R 3 is independently H, alkyl, alkenyl, cycloalkyl, heteroaryl, hydroxyalkyl, cyano, haloalkyl, halo, —C(O)phenyl, —CH(OH)(aryl), —CH 2 (aryl), —CH 2 (heteroaryl), —CF 2 (aryl), —CF 2 (heteroaryl), —CH 2 O(aryl), —CH 2 O(heteroaryl), —CH 2 S(O) x (aryl), and cyclic amino, wherein each of the alkyl, alkenyl, cycloalkyl, heteroaryl, hydroxyalkyl, haloalkyl, —C(O)phenyl, —CH(OH)(aryl), —CH 2 (aryl), —CH 2 (heteroaryl), —CF 2 (aryl), CF 2 (heteroaryl), —CH 2 O(aryl), —CH 2 O(heteroaryl), —CH 2 S(O) x (aryl), and cyclic amino may be optionally substituted with 1, 2 or 3 independent R 7 ; R 4 is aryl, heteroaryl, or cycloalkyl, each optionally substituted with 0, 1, 2 or 3 independent R 8 ; R 5 is independently H, halo, alkyl, alkoxy, cyano, haloalkyl, haloalkoxy, halothioalkyl, thioalkyl, SF 3 , SF 6 , SCN, SO 2 R 11 , cycloalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl; R 6 is independently H, halo, alkyl, alkoxy, cyano, haloalkyl, haloalkoxy, halothioalkyl, thioalkyl, SF 3 , SF 6 , SCN, SO 2 R 11 , cycloalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl; each R 7 is independently cyano, cycloalkyl, haloalkyl, hydroxy, alkoxy, aryl, aryloxy, heteroaryloxy, halo, haloalkoxy, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl; each R 8 is independently cyano, haloalkyl, hydroxy, alkoxy, halo, or haloalkoxy; R 9 is H, halo, or haloalkyl; R 10 is H, alkyl, —Si(R 12 ) 3 , —P(O)(OH) 2 , —CH 2 —O—P(O)(OH) 2 , or —C(O)alkyl optionally substituted with amino; R 11 is independently alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 12 is independently alkyl or aryl; and x is independently 0, 1, or 2.