Patent ID: 7446195

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A is O or S; R 20 is: R 21 is —C(O)N(R 25 R 26 ); R 23 is hydrogen, alkyl, alkoxy, alkoxyalkylamino, amino, alkylamino, dialkylamino, alkylheterocyclyl, alkylaryl, alkylheteroaryl, amido, aryl, alkoxyoxo, halo, heteroaryl, heterocyclyl, cyano, oxo, or aminoalkyl, wherein each of said alkyl, alkoxy, alkoxyalkylamino, amino, alkylamino, dialkylamino, alkylheterocyclyl, alkylaryl, alkylheteroaryl, aryl, alkoxyoxo, heteroaryl, heterocyclyl and aminoalkyl is either unsubstituted or optionally independently substituted with 1-3 independently selected P 1 susbtituents, where P 1 is alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkoxy, amino, alkylamino, dialkylamino, or alkylthio, or two P 1 adjacent moieties together form an alkylenedioxy moiety fused to said aryl, heteroaryl, heterocyclyl ring they are attached to; R 24 is hydrogen, halo, alkyl, alkylene, lower alkyl, aryl, heteroaryl, heterocyclyl, alkoxy, amino, aminoalkyl, alkylamino, dialkylamino, alkylthio, trihaloalkyl, wherein each of said alkyl, alkylene, lower alkyl, aryl, heteroaryl, heterocyclyl, alkoxy, amino, aminoalkyl, alkylamino, dialkylamino, alkylthio, trihaloalkyl is either unsubstituted or optionally independently substituted with 1-3 independently selected P 1 susbtituents, where P 1 is alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkoxy, amino, alkylamino, dialkylamino, or alkylthio; or two R 24 groups, which substitute atoms in a 1,2 or 1,3 arrangement on the phenyl ring said R 24 is shown attached to together form —O—(CH 2 ) y —O—, —S—(CH 2 ) y —O—, —S—(CH 2 ) y —S, —CH═CH—CH═N—, —N═CH—CH═N—, or —S—CH═N— where y is 1 or 2; or alternately R 23 and R 24 together form an aryl, heteroaryl or heterocyclyl ring with said aryl, heteroaryl or heterocyclyl ring being fused to the phenyl ring they are shown attached to; and R 25 and R 26 are linked together to form a six-membered heterocyclyl or heteroaryl.