Patent ID: 8759510

Claim:
A compound of formula I: or a stereoisomer, salt, hydrate, solvate, deuterated analogue, or crystalline form thereof, wherein R 1 is n-alkyl, branched alkyl, cycloalkyl, alkaryl, phenyl or naphthyl, where the phenyl or naphthyl is optionally substituted with at least one of F, Cl, Br, I, OH, OR′, SH, SR′, NH 2 , NHR′, NR′ 2 , NHR′ 2 + , NR′ 3 + , C 1 -C 6 alkyl, halogenated C 1 -C 6 alkyl, halogenated C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halogenated C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, halogenated C 1 -C 6 alkoxy, CO 2 H, CO 2 R′, CONH 2 , CONHR′, CONR′ 2 , CH═CHCO 2 H, or CH═CHCO 2 R′; R 2 is of H, optionally substituted alkyl, cyano, CH 3 , vinyl, O-alkyl, O—(C 1 -C 6 alkyl), hydroxyl C 1 -C 6 alkyl, fluoromethyl, azido, CH 2 CN, CH 2 N 3 , CH 2 NH 2 , CH 2 NHCH 3 , CH 2 N(CH 3 ) 2 , optionally substituted ethynyl alkyne, or halogen; R 3 is CH 3 , CH 2 F, CHF 2 , CF 3 , F, or CN; X is F, OCH 3 , halogen, NH 2 , or N 3 ; Base is of formula b: wherein R 4 and R 5 are independently H, F, CI, Br, I, OH, OR′, SH, SR′, NH 2 , NHR′, NR′ 2 , NHR′ 2 + , NR′ 3 + , heterocycle, C 1 -C 6 alkyl, halogenated C 1 -C 6 alkyl, C 2 -C 6 alkenyl, halogenated C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halogenated C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, halogenated C 1 -C 6 alkoxy, CO 2 H, CO 2 R′, CONH 2 , CONHR′, CONR′ 2 , CH═CHCO 2 H, or CH═CHCO 2 R′; and wherein R′ is an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted alkynyl, an optionally substituted alkenyl, an optionally substituted acyl, or an optionally substituted alkoxyalkyl, where for the instance of NR′ 2 or NHR′ 2 + , each R′ is independent of one another or both R′ are joined to form a heterocycle comprising at least two carbon atoms, and where for the instance of NR′ 3 + , each R′ is independent of one another or at least two R′ are joined to form a heterocycle comprising at least two carbon atom.