Patent ID: 7572904

Claim:
An isolated or recombinant nucleic acid comprising at least one artificially mutated nucleotide relative to SEQ ID NO: 1 or the complementary polynucleotide sequence thereof, wherein the mutated nucleotide comprises one or more of: a deleted nucleotide, an inserted nucleotide, or a substituted nucleotide, and wherein the nucleic acid comprises: (a) a polynucleotide sequence that is greater than 97.8% identical to SEQ ID NO: 1 or the complementary polynucleotide sequence thereof, as determined by Nucleotide-Nucleotide Basic Local Alignment Search Tool (BLASTN) using default parameters, wherein the polynucleotide sequence encodes an infectious, replicating respiratory syncytial virus (RSV); or (b) a polynucleotide sequence encoding an amino acid sequence or unique subsequence selected from the group consisting of (i) an amino acid sequence that is greater than 99.5% identical to SEQ ID NO: 9, and (ii) an amino acid sequence that is greater than 96.4% identical to SEQ ID NO: 10, as determined by BLASTP using default parameters, wherein an RSV that comprises the amino acid sequence is infectious and replicating.