Patent ID: 8721584

Claim:
A system for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient, the system comprising: (a) a measurement receiver configured to receive a glycemic measurement of a patient; and (b) an insulin infusion rate calculator configured to: (i) estimate a maintenance rate (MR) of insulin infusion to maintain euglycemia in the patient; (ii) determine a relationship between a current blood glucose concentration of the patient and a target blood glucose concentration; (iii) determine an MR-dependent insulin infusion rate (IR) based on the estimated MR and based on the relationship between the current blood glucose concentration and the target blood glucose concentration, wherein determining the MR-dependent IR includes assigning the patient to an iso-MR function that defines a relationship between IR values and blood glucose concentrations based on distance from target, and which during hyperglycemia is based on an ideal rate of descent of blood glucose concentration; (iv) measure a glycemic response of the patient while using the determined IR; (v) re-estimate the MR based on the glycemic response of the patient at a previous IR; and (vi) repeatedly perform steps (ii)-(v), wherein the estimated MR in step (v) during each n th iteration is utilized to determine the IR in step (iii) of each (n+1) th iteration, n being an integer.