Patent ID: 8614304

Claim:
A nucleic acid encoding an immunogenic peptide (a) (i) consisting of the amino acid sequence SPQNSIRHNL (SEQ ID NO: 3) or a functional portion of the immunogenic peptide consisting of SEQ ID NO: 3 , (ii) comprising a functional variant of an immunogenic peptide comprising the amino acid sequence SPQNSIRHNL (SEQ ID NQ: 3) or a functional portion of the functional variant, or (iii) a pharmaceutically acceptable salt of (i) or (ii), wherein the peptide, functional portion of (i) or (ii), or functional variant, binds to an MHC Class I molecule, wherein the functional variant comprises no more than one conservative amino acid substitution in SEQ ID NO: 3, wherein the functional portion of (i) comprises 50% or more of the immunogenic peptide consisting of SEQ ID NO: 3, wherein the functional portion of (ii) comprises 50% or more of the functional variant of SEC ID NO: 3, and wherein the nucleic acid encoding SEQ ID NO: 3 or a functional portion thereof is a recombinant nucleic acid, (b) comprising the amino acid sequence SPX 1 NX 2 X 3 RHNL (SEQ ID NO: 6), wherein X 1 is any amino acid except for Gln, X 2 is any amino acid except for Ser, and X 3 is any amino acid except for Ile, a functional portion thereof, or a pharmaceutically acceptable salt thereof, wherein the peptide or functional portion thereof binds to an MHC Class I molecule, and wherein the functional portion comprises 50% or more of SEQ ID NO: 6, or (c) a fusion protein comprising (a) or (b), and an MHC Class I molecule, or a functional portion thereof.