Patent ID: 8575152

Claim:
A compound according to Formula I: or a pharmaceutically acceptable salt thereof, wherein the R groups have the following meanings: —R 1 is —H or —(1-4C)alkyl; —R 2 is —C(O)R 15 or —SO 2 R 15 ; —R 3 is —H, —(1-4C) alkyl or —OR 16 ; —R 4 is —H, —(1-4C)alkyl or —OR 16 ; —R 6 is —H or —C(R 16 )NOR 16 ; —R 7 is —H, -halogen, -cyano; —(1-6C) alkyl, —(2-6C)alkenyl or —(2-6C)alkynyl, all optionally substituted with amino, -hydroxyl or -halogen; —R 8 is —H, -cyano, -halogen, -nitro; —(1-6C) alkyl, —(2-6C)alkenyl, —(2-6C)alkynyl or —O(1-6C)alkyl, all optionally substituted with -amino, -hydroxyl or -halogen; -(hetero)aryl, optionally substituted with -cyano, -halogen, —(1-4C)alkyl, —(1-4C)alkoxy, —(1-4C)alkoxy(1-4C)alkyl or -(hetero)aryl; —C(R 16 )NOR 16 , —C(O)N(R 17 ) 2 , —C(O)R 18 , —C(O)OR 19 , —NHC(O)R 20 , or —NHS(O) 2 R 21 ; —R 9 is —H, -halogen, -cyano, or —(1-4C)alkyl, optionally substituted with -halogen; —R 10 is —(1-4C)alkyl; —R 11 is —H; —R 12 is —H, -cyano or —(1-4C)alkyl; —R 13 is —H, —(1-4C)alkyl, -halogen or -formyl; R 14 is —H, -halogen, -cyano, —(1-4C)alkyl or -(hetero)aryl; —R 15 is —H; —(1-6C)alkyl, —(2-6C)alkenyl, —(2-6C)alkynyl, —O(2-6C)alkyl, -O(2-6C)alkenyl or —O(2-6C)alkynyl, all optionally substituted with one or more —OH, -halogen, -cyano or -(hetero)aryl; -(hetero)aryl, optionally substituted with —(1-4C)alkyl, -halogen or —NH 2 ; —NH 2 , —(di)(1-4C)alkylamino, —(1-4C)alkylthio(1-4C)alkyl, —(1-4C)alkoxy(1-4C)alkyl or —NR 16 OR 16 ; —R 16 is —H, —(1-6C)alkyl, —(2-6C)alkenyl or —(2-6C)alkynyl; —R 17 is —H; —(1-6C)alkyl, optionally substituted with -halogen, —(1-4C)alkoxy or -(hetero)aryl, optionally substituted with -halogen, —(1-4C)alkyl or —(1-4C)alkoxy; —(3-6C)cycloalkyl or -(hetero)aryl, optionally substituted with -halogen, —(1-4C)alkyl or —(1-4C)alkoxy; —R 18 is —H, —NH 2 or —(1-4C)alkyl, optionally substituted with —OH, -halogen, -cyano or —S(1-4C)alkyl; —R 19 is —H or —(1-6C)alkyl, optionally substituted with —OH or -halogen; and —R 20 is —H; —(1-6C)alkyl or —(2-6C)alkenyl, both optionally substituted by -halogen, —O(1-6C)alkyl, -(hetero)aryl, optionally substituted with —(1-4C)alkyl or halogen; —(3-6C)cycloalkyl, —(1-6C)alkoxy; or -(hetero)aryl, optionally substituted with —(1-4C)alkyl); —NH 2 , —NH(1-6C)alkyl or —NH(hetero)aryl); —R 21 is —H or —(1-6C)alkyl.