Patent ID: 7166634

Claim:
A method of treating a microbial infection comprising administering a compound having a structure of Formula I, and pharmaceutically acceptable salts and pro-drug esters thereof: wherein a ring can include one or more additional hetero-atoms, such as nitrogen, sulfur or oxygen; and can include a non-nitrogen hetero-atom, such as sulfur or oxygen, in place of a nitrogen(s) in Formula I; and wherein each of a R 1 , a R 2 , five R 3 , five R 4 , a R 5 , and two R 6 is independently selected from the group consisting of a hydrogen atom, a halogen, a sugar, an aminoalkyl, mono-substituted, poly-substituted or unsubstituted variants of the following residues: saturated C 1 –C 24 alkyl, unsaturated C 2 –C 24 alkenyl or C 2 –C 24 alkynyl, acyl, acyloxy, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, amino, aminocarbonyl, aminocarboyloxy, nitro, azido, phenyl, hydroxy, alkylthio, arylthio, oxysulfonyl, carboxy, cyano, and halogenated alkyl including polyhalogenated alkyl, —CO—O—R 7 , carbonyl —CCO—R 7 , —CO—NR 8 R 9 , —(CH 2 ) n —COOR 7 , —CO—(CH 2 ) n —COOR 7 , —(CH 2 ) n —NR 8 R 9 , ester, alkoxycarbonyl, aryloxycarbonyl, wherein n is an integer from 1 to 6, wherein each R 7 , R 8 and R 9 is separately selected from the group consisting of a hydrogen atom, halogen atom, mono-substituted, poly-substituted or unsubstituted variants of the following residues: saturated C 1 –C 24 alkyl, unsaturated C 2 –C 24 alkenyl or C 2 –C 24 alkynyl, acyl, acyloxy, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, amino, aminocarbonyl, aminocarboyloxy, nitro, azido, phenyl, hydroxy, alkylthio, arylthio, oxysulfonyl, carboxy, cyano, and halogenated alkyl including polyhalogenated alkyl, a 5-membered ring, a 6-membered ring, or combination thereof.