Patent ID: 7005538

Claim:
Compounds with the general formula: or pharmaceutically acceptable salts thereof, wherein: R 1 is selected from: C 5-10 aryl; C 5-10 heteroaryl; and C 5-10 cycloalkyl; said aryl, heteroaryl, cycloalkyl optionally being substituted with 1 to 3 groups of R a ; R 2 is selected from: hydrogen; C 1-4 alkyl; C 2-4 alkenyl; C 2-4 alkynyl and C 1-4 alkoxy; R 1 may be linked through the available carbons to R 2 , thus forming a C 4 –C 8 cycloalkyl, saturated or partially unsaturated, and optionally substituted with 1 to 3 groups of R a ; X is selected from the group consisting of: —O—; —S—; and Se—; R 3 and R 4 are the same or different and are selected from: halogen; C 1-4 alkyl; C 3-7 cycloalkyl; C 2-4 alkenyl; C 2-4 alkynyl; C 1-4 alkoxy; —CF 3 ; —OCF 3 ; —OCF 2 H; —SCH 3 ; —SCF 3 ; and COOH; with the proviso that when R 3 is C 1-4 alkoxy; —OCF 3 ; OCF 2 H; —SCH 3 ; —SCF 3 ; or —COOH, then R 4 must be selected from: halogen; C 1-4 alkyl; C 2-4 alkenyl; C 2-4 alkynyl; C 3-7 cycloalkyl; and —CF 3 ; n is an integer of 0, 1, 2 or 3; Y is selected from the group consisting of: —CO—; —O—; —S—; —CH 2 — and —N(R c )— with the proviso that when Y is —N(R c )—, R 5 is not a carboxylic acid (—CO 2 H), and with the further proviso that when Y is —CH 2 —, n is not zero; R 5 is independently selected from: carboxylic acid (—CO 2 H); phosphonic acid (—PO(OH) 2 ); phosphamic acid (—PO(OH)NH 2 ); sulphonic acid (—SO 2 OH); α-keto carboxylic acid (COCO 2 H); sulphonamide (—SO 2 NHR′); sulphonamide (—NHSO 2 R′), with the proviso that then Y is CO and n is 0; acylsulphonamide (—CONHSO 2 R′) or (—SO 2 NHCOR′); wherein R′ is selected from the group consisting of phenyl, m-nitrophenyl, p-nitrophenyl, and methyl; R a represents a member selected from: hydrogen; halogen; CF 3 ; C 1-4 alkyl; C 2-4 alkenyl; C 2-4 alkynyl; C 1-4 alkoxy; —SMe; —CN; —NO 2 ; and —N(C 0-4 ) 2 ; R c represents a member selected from: hydrogen; C 1-4 alkyl; C 3-4 alkenyl; and C 3-4 alkynyl; included for the variables above are all the possible stereoisomers thereof.