Patent ID: 7863266

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , and R 4 are each independently selected from the group consisting of hydrogen, hydroxy, halo, cyano, â€”CONR a R b , â€”NR a R b , hydroxy(C 1 -C 6 )alkyl, amino(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl optionally substituted with up to 5 fluoro, and (C 1 -C 6 )alkoxy optionally substituted with up to 5 fluoro; each R a and R b are independently hydrogen, (C 1 -C 6 )alkyl, or (C 1 -C 6 )alkylOC(O)â€”, or R a and R b are taken together with the nitrogen to which they are attached to form a heterocycle group optionally substituted with one or more R d ; wherein the heterocycle group optionally include one or more groups selected from O (oxygen), S(O) z , and NR c ; each z is an integer selected from 0, 1, and 2; each R c is independently hydrogen, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, â€”C(O)O(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylO(CH 2 ) m â€”, hydroxy(C 1 -C 6 )alkyl, aryl, â€”C(O)NR g (C 1 -C 6 )alkyl, â€”S(O) z (C 1 -C 6 )alkyl, â€”C(O)(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl optionally substituted with up to 5 fluoro, or (C 1 -C 6 )alkoxy optionally substituted with up to 5 fluoro; each m is an integer selected from 2, 3, 4, 5, and 6; each R d is independently selected from the group consisting of hydrogen, halo, oxo, hydroxy, â€”C(O)NR e R f , â€”NR e R f , hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl optionally substituted with up to 5 fluoro, and (C 1 -C 6 )alkoxy optionally substituted with up to 5 fluoro; R e and R f are each independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, â€”S(O) z (C 1 -C 6 )alkyl, â€”CONR g (C 1 -C 6 alkyl), (C 1 -C 6 )alkylC(O)â€”, and (C 1 -C 6 )alkylOC(O)â€”; R g is hydrogen or (C 1 -C 6 )alkyl; R 5 and R 6 are each independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, and aryl, or R 5 and R 6 are taken together with the nitrogen to which they are attached to form a heterocycle group optionally substituted with one or more R d ; wherein the heterocycle group optionally include one or more groups selected from O (oxygen), S(O) z , and NR c ; R 7 is selected from the group consisting of hydrogen, hydroxy, halo, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl optionally substituted with up to 5 fluoro, and (C 1 -C 6 )alkoxy optionally substituted with up to 5 fluoro; Ar is aryl, or heteroaryl, each optionally substituted with one or more R 8 ; and each R 8 is independently hydrogen, halo, CF 3 , CF 2 H, hydroxy, cyano, nitro, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, or â€”NR a R b .