Patent ID: 8497277

Claim:
A method for treating a B-cell proliferative disorder comprising administering to a subject in need thereof a therapeutically effective amount of an irreversible covalent Btk inhibitor having the structure of Formula (A) wherein A is N; R 1 is L 2 -(substituted aryl), where L 2 is a bond; R 2 and R 3 are independently selected from H, lower alkyl and substituted lower alkyl; R 4 is L 3 -X-L 4 -G, wherein, L 3 , X and L 4 taken together form a nitrogen containing heterocyclic ring; G is wherein, R 6 , R 7 and R 8 are independently selected from among H, lower alkyl or substituted lower alkyl, lower heteroalkyl or substituted lower heteroalkyl, substituted or unsubstituted lower cycloalkyl, and substituted or unsubstituted lower heterocycloalkyl; or a pharmaceutically acceptable salt thereof.