Patent ID: 8409821

Claim:
A method for identifying an inhibitor which lowers the levels of glucuronidated dihydroxyeicosatrienoic acids (DHETs) in a mammal, including the steps of identifying a mammal with hypertension; measuring levels of glucuronidated DHETs from a test sample selected from urine, blood, liver, and kidney of said mammal with hypertension; comparing the levels of glucuronidated DHETs in said test sample to levels of glucuronidated DHETs in a control sample from a non-hypertension mammal of the same species, and determining if said mammal with hypertension contains comparatively elevated levels of glucuronidated DHETs; and treating said mammal containing comparatively elevated levels of glucuronidated DHETs with a molecule known as an inhibitor of epoxide hydrolase and/or UDP-glycuronosyl transferase and identifying the molecule as an inhibitor which lowers the levels of glucuronidated DHETs if the measured DHETs level in said mammal treated with said molecule is lower than that of the measured DHETs level of said mammal containing comparatively elevated level of glucuronidated DHETs that has not been treated with said molecule.