Patent ID: 7846915

Claim:
A method for increasing expression of ApoA-I in a mammal comprising administering a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof wherein: X is selected from CR 11 , and N; Y is selected from CR 12 , and N; R 3 and R 8 are each hydroxyl; R 11 and R 12 are each independently selected from alkoxy, aryloxy, alkenyl, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, phosphate, sulfide, sulfinyl, sulfonyl, sulfonic acid, sulfonamide and thioketone; R 1 , R 5 , R 6 , and R 10 are each independently selected from alkoxy, aryloxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydrogen, hydroxyl, ketone, nitro, phosphate, sulfide, sulfinyl, sulfonyl, sulfonic acid, sulfonamide and thioketone; R 2 , R 4 , R 7 , and R 9 , are each independently selected from aryloxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydrogen, hydroxyl, ketone, nitro, phosphate, sulfide, sulfinyl, sulfonyl, sulfonic acid, sulfonamide and thioketone, or two adjacent substituents selected from R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 11 , and R 12 are connected in a 5 or 6-membered ring to form a bicyclic aryl or bicyclic heteroaryl; each W is independently selected from C and N; and Z is a double bond; provided that: R 2 and R 4 are not each hydroxyl; at least one W is N; when W is N, then p is 0; and when W is C, then p is 1