Patent ID: 8221978

Claim:
A method of selecting a set of normalization probes for use on a comparative genome hybridization array, comprising: a) selecting a first region of a genome to be evaluated by comparative genome hybridization to produce data; b) selecting a second region of said genome for normalization of said data, and c) selecting from a set of candidate probes a sub-set of normalization probes that detect said second region using a computer, wherein candidate probes are ranked and wherein said sub-set of normalization probes are selected using an iterative pairwise elimination method that comprises pairing the probes of said candidate probes that are most proximal to one another to produce a probe pair; eliminating the lowest ranked probe from the probe pair; and repeating said pairing and eliminating steps until a pre-determined number of candidate probes have been eliminated to select said set of normalization probes.