Patent ID: 7700739

Claim:
An isolated binding protein comprising an antigen binding domain, said binding protein capable of binding a p40 subunit of IL-12, said antigen binding domain comprising six CDRs: CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, as defined below: CDR-H1. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 (SEQ ID NO: 55), wherein; X 1 is D, K, T, or S; X 2 is Y, S, or T; X 3 is Y, V, G, W, S, or F; X 4 is I, or M; X is H, G, E, or V; X 6 is V, or is not present; and X 7 is S, or is not present; CDR-H2. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 -X 14 -X 15 -X 16 -X 17 -X 18 -X 19 -X 20 (SEQ ID NO: 56), wherein; X 1 is H, D, G, W, S, Y or R; X 2 is I, or F; X 3 is Y, W, L, S, N, D or G; X 4 is W, P, H, T, or S; X 5 is D, G, E, A, or I; X 6 is D, G, S, T, or N; X 7 is D, G, S, or P; X 8 is K, N, S, E, T, or H; X 9 is Y, T, P, I, or N; X 10 is Y, N, T, H, K, S, or G; X 11 is N, or Y; X 12 is P, N, A, D, or S; X 13 is S, E, D, or P; X 14 is L, K, D, T, or Y; X 15 is K, F, V, M, R, or A; X 16 is S, K, Q, P, or is not present; X 17 is D, G, R, or is not present; X 18 is F, or is not present; X 19 is Q, or is not present; and X 20 is D, or is not present; CDR-H3. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 (SEQ ID NO: 57), wherein; X 1 is R, N, or W; X 2 is G, T, R, P, or H; X 3 is I, R, F, Y, or Q; X 4 is R, V, Y, F, or A; X 5 is S, N, G, A, or R; X 6 is A, Y, L, F, or M; X 7 is M, A, D, L, or F; X 8 is D, M, Y, or W; X 9 is Y, D, or N; X 10 is Y, A, or is not present; X 11 is M, or is not present; X 12 is D, or is not present; and X 13 is Y, or is not present; CDR-L1. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 -X 14 -X 15 (SEQ ID NO: 58) r wherein; X 1 is K, or R; X 2 is A; X 3 is S; X 4 is Q, or E; X 5 is S, or N; X 6 is V, or I; X 7 is S, G, or D; X 8 is N, T, or K; X 9 is D, N, or Y; X 10 is V, G, or L; X 11 is A, I, or H; X 12 is S, or is not present; X 13 is F, or is not present; X 14 is M, or is not present; and X 15 is N, or is not present; CDR-L2. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 (SEQ ID NO: 59), wherein; X 1 is Y, or S; X 2 is A, or T; X 3 is S, or A; X 4 is N, H, S, or Q; X 5 is R, N, or S; X 6 is Y, Q, or I; X 7 is T, S, or G; and X 8 is S, or is not present; and CDR-L3. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 (SEQ ID NO: 60), wherein; X 1 is Q; X 2 is Q; X 3 is D, Y, or S; X 4 is Y, N, K, or I; X 5 is N, T, S, or E; X 6 is S, Y, V, or W; X 7 is P; X 8 is W, F, Y, L, or P; and X 9 is T, or S.