Patent ID: 7026305

Claim:
A compound according to Formula I: wherein: a is 1; R 10 and R 11 are each either H or loweralkyl; R 12 is H, loweralkyl, or —CR 2 R 3 R 4 ; R 13 and R 14 are each either H or form a bond with one another; R is a substituent of the formula: wherein: R′ and R″ are the same or different, are hydrogen atoms or alkyl radicals, X is a bond or represents a carbamoyl, N-methylcarbamoyl, aminocarbonyl or N-methylaminocarbonyl radical, Y is a bond or represents a phenylene radical, R o and R oo are the same or different, and are hydrogen atoms or alkyl radicals, or R o is hydroxyl, hydroxyalkyl, phenyl, benzyl, carbamoylmethyl or else, when Y is a bond and X is carbamoyl, R o can form a 5- or 6-membered ring with the nitrogen atom contained in X, it being possible for this ring to additionally comprise another hetero atom chosen from oxygen or sulphur and, n, m and p are each integers from 0 to 16, and m+n+p is between 4 and 16; or R is a substituent of the formula where R″, R o , R oo , X, Y, n, m and p are as given above and Z is an amino acid radical joined to the adjacent nitrogen atom by a peptide bond to the amino terminus of the amino acid radical; R 1 is a C 2 to C 20 substituted or unsubstituted carboxyacyl; or R 1 is a substituent of the formula where R a and R b are the same or different and are each either hydrogen or loweralkyl, and i is an integer of from 0 to 3; R 2 is a methyl radical or forms with R 4 a methylene radical or an oxo radical, R 3 is a hydroxyl, methyl or hydroxymethyl radical or a radical —CH 2 OR′ 2 , —CH 2 SR′ 2 or —CH 2 NHR′ 2 for which R′ 2 is alkyl, hydroxyalkyl, dihydroxyalkyl, acetamidoalkyl or acetyl, or R′ 2 is an amino radical substituted with a hydroxyalkyl or carboxyhydroxyalkyl radical, or a dialkylamino radical, the alkyl parts of which can form, with the nitrogen atom to which they are joined, a 5- or 6-membered heterocycle optionally containing another hetero atom chosen from oxygen, sulphur or nitrogen and, optionally, N-alkyl, R 4 is a hydrogen atom or forms, with R 2 or R 3 , a methylene radical or an oxo radical, R 5 and R 6 are each hydrogen or together form an oxo radical; or a pharmaceutically acceptable salt thereof.