Patent ID: 8163703

Claim:
A compound of the formula: wherein: R is NR e R f , NR a NR b R c , alkyl, alkenyl, alkynyl, aryl, (CH 2 ) n NR a R b , (CH 2 ) n OR a , C(═NR a )NR b R c , (CH 2 ) n —CH(NHR a )CO 2 R b , (CH 2 ) n —S-alkyl, (CH 2 ) n —S-aryl, Cl, F, Br, I, CN, COOR a , CONR a R b , NHC(═NR a )NHR b , NR a OR b , NR a NO, NHCONHR a , NR a N═NR b , NR a N═CHR b , NR a C(O)NR b R c , NR a C(S)NR b R c , NR a C(O)OR b , CH═N—OR a , NR a C(═NH)NR b R c , NR a C(O)NR b NR c R d , O—C(O)R a , OC(O)—OR a , ONH—C(O)O-alkyl, ONHC(O)O-aryl, ONR a R b , SNR a R b , S—ONR a R b , or SO 2 NR a R b ; n is 1, 2, 3, 4, or 5; R 1 is H, NR a R b , Cl, F, OR a , SR a , NHCOR a , NHSO 2 R a , NHCONHR a , CN, alkyl, aryl, ONR a R b , or NR a C(O)OR b ; R 2 is H and R 3 is OH; or R 2 is OH and R 3 is H; R 4 is OH, alkyl-O—, alkylC(═O)O, alkyl-S—, or alkylC(═O)—S—; R 5 is OH, alkyl-O—, alkylC(═O)O, alkyl-S—, or alkylC(═O)—S— R a , R b , R c , and R d are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic, aryl, acyl, SO 2 -alkyl and NO; or R a and R b together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, azetidino, morpholino, pyrrolino, or thiomorpholino ring; or R b and R c together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, azetidino, morpholino, pyrrolino, or thiomorpholino ring; R e is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic, aryl, acyl, SO 2 -alkyl or NO; and R f is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic, aryl, acyl, SO 2 -alkyl and NO; or R e and R f together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, azetidino, morpholino, pyrrolino, or thiomorpholino ring; which ring is optionally substituted with one or more halo, hydroxyl, alkyl, alkenyl, or alkynyl; wherein any alkyl, cycloalkyl, alkenyl, alkynyl, or acyl is optionally substituted with 1 to 3 substituents selected from the group consisting of alkoxy, acyl, acylamino, acyloxy, oxyacyl, amino, substituted amino, aminoacyl, aryl, aryloxy, cyano, halogen, hydroxyl, nitro, N 3 , carboxyl, carboxyl esters, thiol, thioalkyl, thioaryl, thioheteroaryl, thiocycloalkyl, thioheterocyclic, cycloalkyl, heteroaryl, and heterocyclic; and wherein any aryl, heteroaryl, or heterocycle is optionally substituted with 1 to 3 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, acyl, acylamino, acyloxy, oxyacyl, amino, substituted amino, aminoacyl, aryl, aryloxy, cyano, halogen, hydroxyl, nitro, N 3 , carboxyl, carboxyl esters, thiol, thioalkyl, thioaryl, thioheteroaryl, thiocycloalkyl, thioheterocyclic, cycloalkyl, heteroaryl, and heterocyclic; or a pharmaceutically acceptable salt or prodrug thereof; provided the compound is not 4-methylamino-7-β-(D-ribofuranosyl)-furo[3,2-d]pyrimidine.