Patent ID: 7265138

Claim:
A compound having the structure: or any pharmaceutically-acceptable salt thereof, wherein: Q 1 is C(R 5 ); Q 2 is C(R 6 ); Q 3 is C(R 7 ); Q 4 is C(R 6 ); X 1 is NH, S, S═O, S(═O) 2 or O; X 2 is C(R 8 ); X 3 is C(R 9 ); Y is NH, C(R 10 )(R 11 ), or C(═O); R 1 is selected from R 2 is H, C 1-2 alkyl, —CF 3 , —NH 2 , —OH, —OCH 3 , F, Cl or Br; R 3 is halo, C 1-6 alkyl, C 1-4 haloalkyl, —N(H)C 1-4 alkyl, —N(C 1-4 alkyl)C 1-4 alkyl or —OC 1-4 alkyl; R 4 is Br, I, C 2-6 alkyl, C 1-4 haloalkyl, —C(═O)R b , (C 1-4 haloalkyl)OH, —N(C 1-2 alkyl)C 1-2 alkyl or —CN; wherein if Y is CH 2 and R 3 and R 5 are both Cl, then R 4 is other than isopropyl; R 5 is, independently in each instance, H, halo, C 1-6 alkyl, C 1-4 haloalkyl, —N(H)C 1-4 alkyl, —N(C 1-4 alkyl)C 1-4 alkyl or —OC 1-4 alkyl; R 6 is, independently in each instance, H, F, C 1-6 alkyl, C 1-4 haloalkyl, —N(R a )R a , —OR a , —S(═O) 2 N(R a )R a , —C(═O)N(R a )R a , or —N(R a )C(═O)R b ; R 7 is H, F, C 1-6 alkyl, C 1-4 haloalkyl, —N(R a )R a , —OR a , —S(═O) 2 N(R a )R a , —C(═O)N(R a )R a , or —N(R a )C(═O)R b ; R 8 is H, halo, C 1-6 alkyl, C 1-4 haloalkyl, —N(H)C 1-4 alkyl, —N(C 1-4 alkyl)C 1-4 alkyl or —OC 1-4 alkyl; R 9 is H, halo, C 1-6 alkyl, C 1-4 haloalkyl, —N(H)C 1-4 alkyl, —N(C 1-4 alkyl)C 1-4 alkyl or —OC 1-4 alkyl; R 10 is H, F, C 1-6 alkyl, C 1-4 haloalkyl, —N(R a )R a , or —OR a ; R 11 is H, F, C 1-6 alkyl, C 1-4 haloalkyl, —N(R a )R a , or —OR a ; R a is, independently at each instance, H or C 1-6 alkyl; and R b is, independently at each instance, C 1-6 alkyl.