Patent ID: 7572795

Claim:
A compound of Formula I: or a pharmaceutically acceptable salts thereof, wherein at least one of X 1 , X 2 or X 3 is and any remaining X 1 , X 2 or X 3 is hydrogen; A 1 and A 2 are each independently selected from the group consisting of optionally-substituted alkyl, optionally-substituted cycloalkyl, optionally-substituted aryl, optionally-substituted aralkyl, optionally-substituted heterocyclo and optionally-substituted heteroaryl; R 1 , R 3 and R 5 are each independently selected from the group consisting of hydrogen, optionally-substituted alkyl, —OR 14 , —C(═O)NR 14 R 14a , —NR 14 R 14a , —SO 2 NR 14 R 14a , —NR 14 SO 2 NR 14a R 14b , —NR 14a SO 2 R 14 , —NR 14 C(═O)R 14a , —NR 14 CO 2 R 14a , —NR 14 C(═O)NR 14a R 14b , halogen, cyano, optionally-substituted cycloalkyl, optionally-substituted aryl, optionally-substituted heterocyclo and optionally-substituted heteroaryl; R 2 is independently selected from the group consisting of hydrogen and optionally-substituted alkyl; R 4 is independently selected from the group consisting of: R 6 is attached to any available carbon atom of the phenyl ring and at each occurrence is independently selected from the group consisting of optionally-substituted alkyl, halogen, trifluoromethoxy, trifluoromethyl, hydroxy, alkoxy, alkanoyl, alkanoyloxy, thiol, alkylthio, ureido, nitro, cyano, carboxy, carboxyalkyl, alkoxycarbonyl, alkylthiono, arylthiono, arylsulfonylamine, alkylsulfonylamine, sulfonic acid, alkysulfonyl, sulfonamido, phenyl, benzyl, aryloxy and benzyloxy, wherein each R 6 group in turn may be further substituted by one to two R 18 ; R 14 , R 14a and R 14b are independently selected from the group consisting of hydrogen, optionally-substituted alkyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclo, and optionally-substituted heteroaryl, except when R 14 is joined to a sulfonyl group, as in —S(═O)R 14 , —SO 2 R 14 , and —NR 14a SO 2 R 14 , then R 14 is not hydrogen; R 18 is selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, halogen, haloalkyl, haloalkoxy, cyano, nitro, amino, C 1-4 alkylamino, aminoC 1-4 alkyl, hydroxy, hydroxyC 1-4 alkyl, alkoxy, C 1-4 alkylthio, aryl, heterocyclo, (aryl)alkyl, aryloxy, and (aryl)alkoxy; R 27 and R 28 are independently selected from the group consisting of hydrogen, optionally-substituted alkyl, optionally-substituted cycloalkyl, optionally-substituted aryl, optionally-substituted aralkyl, optionally-substituted heterocyclo and optionally-substituted heteroaryl; one of D, E, G, J or L is ═N— and each remaining D, E, G, J or L is ═C—; m is 0, 1, 2 or 3; n is 0 or 1; and k is 0, 1 or 2.