Patent ID: 8309593

Claim:
A method of treating polycystic kidney disease in a subject, the method comprising administering to the subject having polycystic kidney disease an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein X is —(CR 5 R 6 ) n -Q-; Q is —O—, —S—, —C(O)—, —C(S)—, —C(O)O—, —C(S)O—, —C(S)S—, —C(O)NR 7 —, —NR 7 —, —NR 7 C(O)—, —NR 7 C(O)NR 7 —, —OC(O)—, —SO 3 —, —SO—, —S(O) 2 —, —SO 2 NR 7 —, or —NR 7 SO 2 —; and R 4 is —H, a substituted or unsubstituted aliphatic group, or a substituted or unsubstituted aryl group; or X is —O—, —S— or —NR 7 —; and R 4 is a substituted or unsubstituted aliphatic group, or substituted or unsubstituted aryl group; or X is —(CR 5 R 6 ) n —; and R 4 is a substituted or unsubstituted cyclic alkyl group, or a substituted or unsubstituted cyclic alkenyl group, a substituted or unsubstituted aryl group, —CN, —NCS, —NO 2 or a halogen; or X is a covalent bond; and R 4 is a substituted or unsubstituted aryl group; and R 5 and R 6 are each independently —H, —OH, —SH, a halogen, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted lower alkylthio group, or a substituted or unsubstituted lower aliphatic group; n is 1, 2, 3, 4, 5 or 6; and each R 7 is independently —H, a substituted or unsubstituted aliphatic group, or a substituted or unsubstituted aryl group, or R 7 and R 4 taken together with the nitrogen atom of NR 7 R 4 form a substituted or unsubstituted non-aromatic heterocyclic group; R 30 is i) hydrogen; ii) an aryl group optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl, amino, alkylamino, dialkylamino, alkoxy, nitro, cyano, hydroxy, haloalkoxy, alkoxycarbonyl, alkylcarbonyl and haloalkyl; or iii) an alkyl group optionally substituted with one or more substituents selected from the group consisting of halogen, amino, alkylamino, dialkylamino, alkoxy, nitro, cyano, hydroxy, haloalkoxy, alkoxycarbonyl, alkylcarbonyl and haloalkyl; each of A and B independently is halogen, hydroxy, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy or C1-C6 haloalkoxy; each k′ is independently 0, 1 or 2; each k″ is independently 0, 1 or 2; and each m′ is independently 0, 1 or 2.