Patent ID: 8507673

Claim:
A process for preparing compounds of Formula I: or salts thereof, wherein R 1 is H, halo, alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, amino; R 2 is alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, amino; R 3 is H, alkyl, aryl, cycloalkyl; R 4 is alkyl, alkenyl, aryl, arylalkyl, arylalkenyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl; comprising: (a) reacting a compound of Formula II: wherein R 8 is C 1-8 alkyl, C 6-14 aryl, C 7-20 arylalkyl, C 4-7 heterocyclic, C 5-15 heterocyclicalkyl, C 4-7 heteroaryl, C 5-15 heteroaralkyl, C 1-8 alkoxy, C 6-14 aryloxy, C 7-20 arylalkoxy, C 4-7 heterocyclicoxy, C 5-15 heterocyclicalkoxy, C 4-7 heteroaryloxy, or C 5-15 heteroaralkyloxy; X is F, Cl, Br, or I; R 1 is as defined above; and R 2 is as defined above and is, optionally, protected with a protecting group; with a compound of Formula III: R 3 R 4 NH Formula III wherein R 3 is as defined above and is, optionally, protected with a protecting group; R 4 is as defined above and is, optionally, protected with a protecting group; in a solvent system comprising water and one or more organic solvents, optionally in the presence of a base; and (b) deprotecting the resulting compound to produce a compound of Formula I or a salt thereof; wherein each alkyl group may be optionally substituted by one or more halo, alkyl, lower alkyl, alkenyl, cycloalkyl, acyl, hydroxy, hydroxyalkyl, heterocyclic, heteroaryl, aryl, amino, aminoalkyl, —NR x R y , oxo, cyano, carboxy, carboxyalkyl, alkoxycarbonyl, —OR x , —C(O)R x , —C(O)—NH 2 , —C(O)—N(H)R x , —C(O)—N(H)O R x , —C(O)—NR x R y , —NR y C(O)R x , —NR y C(O)NR x R y , —OC(O)NR x R y , —NR y C(O)OR x , —S(O) n —R x , —S(O) 2 —NH 2 , —S(O) n —N(H)R x and/or —S(O) 2 —NR x R y , wherein R x and R y are each independently C 1-6 alkyl.