Patent ID: 7259142

Claim:
A compound of formula: in which L is sulfur, sulfoxide, oxygen or methylene, in which (i) aa 1 is L-α-amino-adipic acid (Adi) and aa 4 is Glu or (ii) each of aa 1 and aa 4 is Adi, in which, optionally, one or more of Tyr 3 , Val 6 , Met 8 and Tyr 9 is substituted with a D-configuration analog thereof or Met 8 is substituted with Nle 8 , and in which, optionally, there is a conservative or neutral amino acid substitution at either one or both of Leu 2 and Gly 7 , wherein said compound binds an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, and whereupon binding to a growth factor receptor-bound protein 2 (Grb2), the compound has a turn conformation.