Patent ID: 7312330

Claim:
An amine compound of the formula 1: wherein A, B and Y are CR 2′ R 2′ ; W is N; and Z is CR 4 ; R 1 is selected from phenyl, unsubstituted or substituted with alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, amino, substituted or unsubstituted sulfo, substituted or unsubstituted sulfonyl, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thiol; or R 1 is selected from substituted or unsubstituted pyridyl, substituted or unsubstituted indolyl, substituted or unsubstituted benzimidazolyl, substituted or unsubstituted benzo(1,4)dioxinyl, substituted or unsubstituted indazolyl, substituted or unsubstituted tetrahydroquinoline, and substituted or unsubstituted tetrahydroisoquinoline; R 2 is H; and each R 2′ is independently selected from hydrogen, substituted or unsubstituted C 1 -C 6 alkyl; R 3 is selected from substituted or unsubstituted phenyl; R 4 is selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, amino, substituted or unsubstituted sulfo, substituted or unsubstituted sulfonyl, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thiol; however, provided that when A, B and Y all are CH 2 s, W is N, Z is CR 4 , then R 4 is other than alkylamino, dialkylamino or alkylarylamino; or a pharmaceutically acceptable salt, or solvate or stereoisomers or tautomers thereof.