Patent ID: 8217062

Claim:
A topical composition consisting essentially of: as an active ingredient a dihydropyridine calcium antagonist and optionally a salt of the dihydropyridine calcium antagonist, wherein 10% or more of the dihydropyridine antagonist is present in uncharged form; and a pharmaceutically acceptable carrier consisting essentially of at least one stiffening agent selected from the group consisting of cetyl alcohol, stearyl alcohol, cetostearyl alcohol, eicosanol, docosanol, sorbitane monopalmitate, sorbitane monostearate, glyceryl monopalmitate, glyceryl monostearate, or glyceryl monopalmitostearate; and at least one release modifier selected from the group consisting of dodecanol, tetradecanol, palmitoyl alcohol, oleyl alcohol, linoleyl alcohol, polyoxyethylene lauryl ether, polyoxyethylene myristyl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, sorbitane monolaurate, sorbitane monooleate, or glyceryl monooleate, wherein the stiffening agent is present in an amount of 10 to 30% by weight and the release modifier is present in an amount of 1 to 15% by weight, the weight % being based on the total weight of the composition.