Patent ID: 8742118

Claim:
A method for the preparation of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula (I) or of a salt thereof: wherein R is a linear or branched C1-C6 alkyl group, comprising the following steps: (a) converting of a 5-halogen-2-alkoxypyridine of formula (IV) wherein X is selected from the group consisting of: chlorine, bromine and iodine and R is a linear or branched C1-C6 alkyl group, into a halide of (6-alkoxypyridin-3-yl)magnesium of formula (III) or in a lithium chloride complex thereof of formula all-bis): wherein X′ is selected from the group consisting of: chlorine, bromine and iodine, (b) reacting of the compound obtained in the step (a) with a 2-halogenpyridine or 2-pseudohalogenpyridine of formula (II) wherein X′ is selected from the group consisting of: chlorine, bromine, iodine, triflate, nonaflate, mesylate, tosylate and besylate or —O(C═O)NR′ 2 and wherein R′ is a linear or branched C 1 -C 4 alkyl group or is phenyl or benzyl, to provide the compound of formula (I) or a salt thereof.