Patent ID: 7476676

Claim:
A method of treating a bone fracture in a mammal comprising: administering to a mammal having a bone fracture an effective amount of a GSK-3β inhibitor of Formula (I) wherein: R 1 and R 2 independently represent hydrogen, alkyl, halo, haloalkyl, alkylthio, hydroxy, alkoxy, cyano, nitro, amino, acylamino, monoalkylamino, or dialkylamino; R 3 represents hydrogen, alkyl, cycloalkyl, heteroalkyl, —COR 7 (wherein R 7 is hydrogen or alkyl), or phenyl optionally substituted with one or two substituents independently selected from the group consisting of hydrogen, alkyl, haloalkyl, alkylthio, hydroxy, alkoxy, cyano, nitro, amino, acylamino, monoalkylamino, and dialkylamino; R 4 and R 5 independently represent hydrogen, alkyl, halo, haloalkyl, alkylthio, hydroxy, alkoxy, cyano, nitro, amino, acylamino, monoalkylamino, or dialkylamino; R 6 is heteroalkyl, heterocyclyl, heterocyclylalkyl, heteroalkylsubstituted heterocyclyl, heteroalkylsubstituted cycloalkyl, hetereosubstituted cycloalkyl, —OR 8 , —S(O) n R 8 (wherein n is 0 to 2; and R 8 is heteroalkyl, heteroaralkyl, heterocyclyl, or heterocyclylalkyl), —NR 9 R 10 (wherein R 9 is hydrogen or alkyl and R 10 is heteroalkyl, heteroaralkyl, heterosubstituted cycloalkyl, heterocyclyl, or heterocyclylalkyl), or —X-(alkylene)-Y-Z (wherein X is a covalent bond, —O—, —NH—, or —S(O) n1 — where n1 is 0 to 2, and Y is —O—, —NH—, or —S—, and Z is heteroalkyl or SiR 11 R 12 R 13 where R 11 , R 12 and R 13 are independently hydrogen or alkyl), or R 6 together with R 4 forms a methylenedioxy or ethylenedioxy group when they are adjacent to each other; or a pharmaceutically acceptable salt thereof.