Patent ID: 8119798

Claim:
A compound of formula II-3: or a pharmaceutically acceptable salt thereof, wherein: R 1 is (C 1 -C 6 )alkyl optionally substituted with 1, 2, or 3 R 6 ; is (C 3 -C 6 )cycloalkyl or aryl optionally substituted on carbon with 1, 2, or 3 R 6 ; R 2 is hydrogen or (C 1 -C 6 )alkyl which may be optionally substituted on carbon with 1, 2, or 3 R 6 ; R 3 is —OH, —O—(C 1 -C 6 )alkyl, —NH 2 , —NH(C 1 -C 6 )alkyl), —N((C 1 -C 6 )alkyl) 2 , —NH(O—C 1 -C 6 )alkyl), —O-aralkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 R 6 ; R 4a is hydrogen, (C 1 -C 6 )alkyl, or (C 3 -C 6 )cycloalkyl which may be optionally substituted on carbon with 1, 2, or 3 R 6 ; R 4b is hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 R 6 ; or R 4a and R 4b , together with the carbon to which they are attached, form a (C 3 -C 6 )cycloalkyl, aryl or heteroaryl group, any of which may be optionally substituted on carbon with 1, 2, or 3 R 6 ; R 5 is hydrogen, (C 1 -C 6 )alkyl, or (C 3 -C 6 )cycloalkyl; R 6 is halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, —NH(C 1 -C 6 )alkyl, —N((C 1 -C 6 )alkyl) 2 , aryl, heteroaryl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyloxy, (C 2 -C 6 )alkynyloxy, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfonyl, amino, (C 1 -C 6 )alkylamino, di-[(C 1 -C 6 )alkyl]amino, formyl, —C(═O)(C 1 -C 6 )alkyl, —C(═N)(C 1 -C 6 )alkyl, carboxy, —CO 2 (C 1 -C 6 )alkyl, —CONH 2 , —C(═N)NH 2 , —C(═N)NH(C 1 -C 6 )alkyl), —C(═N)N(C 1 -C 6 )alkyl) 2 , —CONH(C 1 -C 6 )alkyl, —CON((C 1 -C 6 )alkyl) 2 , —OC(O)(C 1 -C 6 )alkyl, —OC(O)NH 2 , —OC(O)NH(C 1 -C 6 )alkyl, —OC(O)NH((C 1 -C 6 )alkyl) 2 , —NHC(O)(C 1 -C 6 )alkyl, —N(C 1 -C 6 )alkyl-C(O)(C 1 -C 6 )alkyl, —NH—C(O)NH 2 , —N(C 1 -C 6 )alkyl-C(O)NH 2 , —N(C 1 -C 6 )alkyl-C(O)NH(C 1 -C 6 )alkyl, —N(C 1 -C 6 )alkyl-C(O)NH(C 1 -C 6 )alkyl) 2 , —NH—C(O)NH(C 1 -C 6 )alkyl) 2 , —NH—(C 1 -C 6 )alkylsulfamoyl, N,N-di-[(C 1 -C 6 )alkyl]sulfamoyl, (C 1 -C 6 )alkylsulfonylamino, or —N—(C 1 -C 6 )alkyl-(C 1 -C 6 )alkylsulfonylamino, any of which may be optionally substituted on carbon with R 7 ; R 7 is halogen, trifluoromethyl, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, cyano, nitro, or hydroxyl; and R 8 is selected from hydrogen and (C 1 -C 6 )alkyl.