Patent ID: 7429593

Claim:
A compound of formula (III): in which Het 2 is 3-furyl, thienyl, pyrrolyl, pyrazolyl, thiazolyl, oxazolyl, isoxazolyl, pyrimidinyl or imidazolyl; R is a hydrogen, or lower alkyl; W 2 is CR 8 or N; Y 1 is hydrogen, halogen, lower alkyl, carboxy, lower alkoxycarbonyl, cyano, or a monocyclic aromatic heterocyclic group selected from the group consisting of pyrrolyl, imidazolyl, pyrazolyl, pyridazinyl, pyrimidyl, pyrazinyl, triazolyl, triazinyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiadiazolyl, furyl and thienyl; Y 2 is hydrogen, halogen, lower alkyl, carboxy, lower alkoxycarbonyl, cyano, or a monocyclic aromatic heterocyclic group; R 6 , R 7 , R 8 , R 9 and R 10 are independently hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, carboxy, lower alkoxycarbonyl, amino, or acyl; any two of R 6 , R 7 , and R 8 may be combined to form a cyclic ring group; wherein the lower alkyl, lower alkoxycarbonyl, lower alkoxy, amino and acyl of R, Y 1 , Y 2 , R 6 , R 7 , R 8 , R 9 and/or R 10 are optionally substituted with a substituent selected from the group consisting of halogen, hydroxy, lower alkoxy, a monocyclic or bicyclic carbocyclic group, acyl, acyloxy, carboxy, lower alkoxycarbonyl, amino, lower alkylamino, nitro, a monocyclic heterocyclic group and a bicyclic heterocyclic group; and the phenyl and monocyclic aromatic heterocyclic group are optionally substituted with a substituent selected from the group consisting of halogen; hydroxy; lower alkyl optionally substituted with halogen, hydroxy, or lower alkoxy; lower alkoxy optionally substituted with halogen, hydroxy, carboxy, or lower alkoxycarbonyl; lower alkenyl optionally substituted with halogen, hydroxy, carboxy, or lower alkoxycarbonyl; lower alkenyloxy optionally substituted with halogen or hydroxy; lower alkylthio; a non-aromatic carbocyclic group optionally substituted with halogen, hydroxy, or lower alkyl; acyl; acyloxy; carboxy; lower alkoxycarbonyl; lower alkenyloxycarbonyl; amino optionally substituted with lower alkyl or acyl; hydrazino, nitro; cyano; a monocyclic or bicyclic aromatic carbocyclic group optionally substituted with halogen, hydroxy, lower alkyl, or lower alkoxy; a monocyclic or bicyclic heterocyclic group; phenoxy optionally substituted with halogen, hydroxy, or lower alkyl; monocyclic aromatic heterocyclic oxy; oxo; and alkylenedioxy; and m is 1 or 2; or a pharmaceutically acceptable salt thereof; provided that both of R 6 and R 7 are hydrogen, when Het 2 is 3-furyl or thienyl.