Patent ID: 8765815

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is an A-G(=K)—X—Y group, A is alkyl or absent; G is selected from the group consisting of C, S and PRa; K is selected from the group consisting of O and S; X is selected from the group consisting of O, S and NRb, or absent; and Y is hydroxyalkyl, R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl or aryl; each of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro and amino, or, alternatively, at least two of R 2 , R 3 , R 4 , R 5 and R 6 , and/or of R 7 , R 8 , R 9 and R 10 form a five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring; and each of Ra and Rb, is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl, provided that at least one of R 7 , R 8 , R 9 and R 10 is an electron-withdrawing group, and that the compound has at least two electron-withdrawing groups, each of said electron-withdrawing groups being nitro.