Patent ID: 8389527

Claim:
A compound according to formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 and R 3 are each independently selected from hydrogen, halogen, cyano, and C 1-4 alkyl; R 2 is selected from cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 4 is selected from hydrogen, alkyl, substituted alkyl, —C(═O)alkyl, —S(O) 2 alkyl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 5 is selected from hydrogen and C 1-4 alkyl; R 6 is selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; and R 7 is selected from hydrogen and C 1-4 alkyl; or R 6 and R 7 together with the nitrogen atom to which they are attached form an optionally substituted 5-, 6- or 7-membered monocyclic heteroaryl or heterocyclo ring, or an optionally substituted 7- to 11-membered bicyclic heteroaryl or heterocyclo ring; R 8 is selected from hydrogen and C 1-4 alkyl; and provided that if R 2 is R 4 is R 6 is then R 3 is not hydrogen; wherein: said heterocyclo is a fully saturated or unsaturated, aromatic or nonaromatic cyclic group, which is a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic ring system, which has at least one heteroatom selected from nitrogen, oxygen, and sulfur in at least one carbon atom-containing ring; said heterocyclo may be attached at any heteroatom or carbon atom; said heteroaryl is a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic aromatic ring system, which has at least one heteroatom selected from nitrogen, oxygen, and sulfur and at least one carbon atom-containing ring; and said heterocyclo and heteroaryl are substituted with one to four substituents selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, arylalkyloxy, halo, haloalkyl, hydroxy, alkoxy, oxo, alkanoyl, aryloxy, alkanoyloxy, amino, alkylamino, arylamino, arylalkylamino, disubstituted amines in which the 2 amino substituents are selected from alkyl, aryl or arylalkyl; alkanoylamino, aroylamino, aralkanoylamino, substituted alkanoylamino, substituted arylamino, substituted aralkanoylamino, thiol, alkylthio, arylthio, arylalkylthio, alkylthiono, arylthiono, arylalkylthiono, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, sulfonamido, substituted sulfonamido, ureido, nitro, cyano, carboxy, carboxyalkyl, carbamyl, substituted carbamyl, alkoxycarbonyl, aryl, substituted aryl, guanidino, and heterocyclyl, and substituted heterocyclyl.