Patent ID: 8716345

Claim:
A compound of formula (I) wherein A 1 is —C(O)—N(R 16 R 17 ); A 2 , A 3 and A 4 are hydrogen; D is —O—, —S—, —S(O)— or —S(O) 2 —; E is aryl, wherein aryl is phenyl or substituted phenyl; R 1 is hydrogen or alkyl; R 2 is hydrogen, alkyl or cycloalkyl; R 3 and R 4 are each independently hydrogen, alkyl, carboxyalkyl, carboxycycloalkyl, cycloalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle or heterocyclealkyl, or R 3 and R 4 taken together with the atoms to which they are attached form a ring selected from the group consisting of cycloalkyl and heterocycle; R 16 and R 17 are each independently hydrogen, alkyl, alkoxy, alkylsulfonyl, aryl, arylalkyl, aryloxy, aryloxyalkyl, arylsulfonyl, carboxy, carboxyalkyl, carboxycycloalkyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfonyl, heteroaryl, heteroarylalkyl, heteroaryloxyalkyl, heteroaryloxy, heteroarylsulfonyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, heterocycleoxy, heterocyclesulfonyl, hydroxy, or -alkyl-C(O)N(R 201 R 202 )or R 16 and R 17 taken together with the atom to which they are attached form a heterocycle; and R 201 and R 202 are independently selected from the group consisting of hydrogen and alkyl; or a pharmaceutically acceptable salt thereof.