Patent ID: 7968577

Claim:
A compound according to formula (I), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein: M is aryl; M a is a linker between C and M and is a bond; Q is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, and substituted C 1 -C 4 alkyl; Z is selected from the group consisting of cycloalkyl, heterocyclo, aryl, and heteroaryl; Z a is a linker between N and Z and is a bond; R 1 , R 2 , R 3 , and R 4 at each occurrence are independently selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, nitro, cyano, —OR 10 —SR 10 —NR 10 R 11 , —C(═O)R 10 , —CO 2 R 10 , —C(═O)NR 10 R 11 , —O—C(═O)R 10 , —NR 10 C(═O)NR 10 R 11 , —NR 10 C(═O)R 11 , —NR 10 C(═O)OR 11 , —NR 10 C(S)OR 11 , —S(═O) p R 12 , —NR 10 SO p R 12 , —SO p NR 10 R 11 , cycloalkyl, heterocyclo, aryl, and heteroaryl; R 6 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, —C(═O)R 17 , —CO 2 R 17 , —C(═O)NR 16 R 17 , cycloalkyl, heterocyclo, and heteroaryl, provided that the point of attachment occurs at a carbon atom on the heterocyclo or heteroaryl; R 7 is selected from the group consisting of halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, nitro, —OR 19 , —SR 19 , —NR 19 R 20 , —C(═O)R 19 , —CO 2 R 19 , —C(═O)NR 19 R 20 , —O—C(═O)R 19 , —NR 19 C(═O)R 20 , —NR 19 C(═O)OR 20 , —NR 19 C(═S)OR 20 , —S(═O) p R 21 , —NR 19 SO 2 R 21 , —SO 2 NR 19 R 20 , cycloalkyl, heterocyclo, aryl, and heteroaryl, provided that if R 7 is OH then R 6 is selected from a group other than unsubstituted or substituted alkyl; or R 6 and R 7 are taken together with the carbon to which they are attached to form a cycloalkyl, or heterocyclo group; R 10 , R 11 , R 16 , R 17 , R 19 , and R 20 at each occurrence are independently selected from the group consisting of (i) hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; or (ii) R 10 is taken together with R 11 , and/or R 16 is taken together with R 17 ; and/or R 19 is taken together with R 20 to form a 4- to 7-membered heteroaryl ring, or a 4- to 7-membered heterocyclo ring; R 12 and R 21 are independently selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; R 22 is hydrogen; and p is 1 or 2.