Patent ID: 8652471

Claim:
A method of treating a subject with a coagulopathy, comprising administering to said subject a monoclonal antibody that is capable of binding the Kunitz 2 (K2) domain of tissue factor pathway inhibitor (TFPI), wherein the heavy chain of said antibody comprises: a CDR1 sequence of amino acids 31 to 35 (NYAMS) of SEQ ID NO: 18; a CDR2 sequence of amino acids 50 to 66 (TISRSGSYSYFPDSVQG) of SEQ ID NO: 18; and a CDR3 sequence of amino acids 99 to 110 (LGGYDEGDAMDS) of SEQ ID NO: 18, and wherein the light chain of said antibody comprises: a CDR1 sequence of amino acids 24 to 39 (KSSQSLLESDGKTYLN) of SEQ ID NO: 15; a CDR2 sequence of amino acids 55 to 61 (LVSILDS) of SEQ ID NO: 15; and a CDR3 sequence of amino acids 94 to 102 (LQATHFPQT) of SEQ ID NO: 15.