Patent ID: 8835456

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: m is 1 or 2; n is 0, 1, or 2; where A is a group of the formula or where X 1 , X 2 , and X 3 are independently N or CH, where each CH is unsubstituted or substituted with a substituent independently chosen from hydroxyl, halogen, C 1 -C 2 alkyl, and C 1 -C 2 alkoxy; where A 2 is chosen from phenyl, pyridyl, thienyl, benzylfuranyl, and pyrimidinyl, each of which is unsubstituted or substituted with one or more substituents independently chosen from amino, cyano, hydroxyl, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, mono- and di-C 1 -C 4 alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; U 1 and U 2 are independently chosen from hydrogen, C 2 -C 6 alkanoyl, C 1 -C 6 alkylester, mono- and di-C 1 -C 6 alkylcarbamate, mono- and di-C 1 -C 6 alkylcarboxamide, mono- and di-C 1 -C 6 alkylsulfonamide, and C 1 -C 6 alkylsulfonamide; each of which U 1 and U 2 other than hydrogen is unsubstituted or substituted with 1 or more substituents independently chosen from amino, cyano, hydroxyl, halogen, mono- and di-C 1 -C 4 alkylamino, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; V 1 and V 2 are independently chosen C 1 -C 4 alkylene, each of which is unsubstituted or substituted with one or more substituents independently chosen from amino, cyano, hydroxyl, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, mono- and di-C 1 -C 4 alkylamino, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; Z 1 and Z 2 are independently chosen from —SO 2 —, —NHSO 2 , —(C═O)—, —(C═O)O—, —NH—, and —(C═O)NH—, each of which may be in either orientation; R 1 is absent or R 1 is one or more substituents independently chosen from hydroxyl, halogen, C 1 -C 2 alkyl, and C 1 -C 2 alkoxy; R 3 is chosen from hydrogen, from hydroxyl, halogen, C 1 -C 2 alkyl, and C 1 -C 2 alkoxy; R 4 is absent or R 4 is one or more substituents present on either ring of the bicyclic system on which it is shown, which substituents are independently chosen from hydroxyl, halogen, C 1 -C 2 alkyl, and C 1 -C 2 alkoxy.