Patent ID: 7052906

Claim:
A nucleic acid encoding a chimeric receptor comprising an extracellular ligand binding domain comprising a binding domain derived from a V H or V L antibody variable domain; a TCRα, TCRβ, TCRγ, or TRCδ T-cell receptor variable region domain: or a CD8α, CD8β, CD11A, CD11B, CD11C, CD18, CD29, CD49A, CD49B, CD49C, CD49D, CD49E, CD49F, CD61, CD41, or CD51 chain, an extracellular spacer domain, a synthetic transmembrane domain comprising TM24 (SEQ ID NO:22), and an intracellular signaling domain comprising a signaling domain derived from the zeta, eta, or epsilon chain of the T-cell receptor: CD28; CD4; CD8; the gamma chain of the Fc receptor; or a signaling component from an interleukin, TNF, or interferon receptor, or from GMCSF, ZAP-70, fyn, lck, Itk, syk, LFA-1, LFA-2, B29, MB-1, CD3δ, CD3γ, CD5, or CD2.