Patent ID: 7202225

Claim:
A composition comprising, a nonionic block copolymer, wherein the block copolymer has the following formula: HO(C 2 H 4 O) b (C 3 H 6 O) a (C 2 H 4 O) b H wherein “a” is a number such that the molecular weight of the hydrophobe (C 3 H 6 O) a , represented by the polyoxypropylene portion of the copolymer, is between approximately 750 and 15,000 Daltons; and “b” is a number such that the hydrophile (C 2 H 4 O) b portions of the block copolymer, represented by the polyoxyethylene portions of the block copolymer, together are approximately 1% to approximately 50% of the total weight of the block copolymer, and one or more nucleic acid molecules selected from the group consisting of: oligonucleotides, antisense oligonucleotides, triplex DNA compounds, ribozymes, and mixtures thereof; wherein the composition further comprises an antimicrobial drug selected from the group consisting of; rifampin, isoniazid, ethambutol, gentamicin, tetracycline, erythromycin, pyrazinamide, streptomycin, clofazimine, rifabutin, fluoroquninolones, azithromycin, clarithromycin, dapsone, doxycyline, ciprofloxacin, ampicillin, amphotericin B, fluconazole, ketoconazole, pyrimethamine, sulfadiazine, clindamycin, paromycin, diclazaril, atovaquone, pentamidine, acyclovir, trifluorouridine, AZT, DDI, DDC, forscarnet, viral protease inhibitors, ganciclovir, ribavirn, antiviral nucleoside analogs, and a combination thereof.