Patent ID: 7320754

Claim:
A method of preparing at least one multi-modal anion-exchange ligand, which method comprises the steps of (a) providing at least one scaffold defined by the general formula (I) below wherein A, B and X irrespective of each other are carbon atoms or any heteroatoms, m is any integer between 0 and 4, and the functional group N is a nitrogen, which either replaces one X or is attached to any one of A, B and X; (b) optionally derivatizing the nitrogen of the scaffold(s) to provide an anion-exchanging group and/or to protect the amine, while retaining the cyclic structure of the scaffold; and (c) subjecting said scaffold to aminolysis to open up the cyclic structure of the resulting derivative by adding a reagent comprising an amine coupled to a residue R to add said amine to the carbonyl carbon of the opened scaffold.