Patent ID: 7087411

Claim:
An isolated nucleic acid molecule encoding a fusion polypeptide capable of binding vascular endothelial growth factor (VEGF) consisting of components (R1R2) X , and a multimerizing component (MC) capable of interacting with another MC to form a multimeric structure, wherein X≧1, R1 is VEGF receptor component Ig domain 2 of Flt-1 consisting of amino acids 27–126 of SEQ ID NO: 8 or 27–129 of SEQ ID NO: 10, R2 is Ig domain 3 of Flk-1 consisting of amino acids 127–228 of SEQ ID NO: 8 or 130–231 of SEQ ID NO: 10, and MC is an amino acid sequence between 1 to about 200 amino acids in length having at least one cysteine residue.