Patent ID: 7943646

Claim:
A benzamidine derivative represented by the following formula 1: wherein R 1 is C 1 to C 6 alkyl which is unsubstituted or substituted with one group selected from pyridine and C 3 to C 6 cycloalkyl ; phenyl; benzyl; pyridinyl which is unsubstituted or substituted with C 1 to C 6 alkyl; guanidino; NR 6 R 7 ; (wherein A is C 1 to C 6 alkyl, and m is an integer of 2 to 6); or group which is unsubstituted or substituted with C 1 to C 6 alkyl; R 2 is a primary or secondary amine, which is NR 8 R 9 , pyrrolidine, piperidine or imidazole; R 3 and R 4 are each independently hydrogen; halogen; hydroxy; C 1 to C 6 alkyl which is unsubstituted or substituted with halogen; C 3 to C 6 cycloalkylamino; C 1 to C 6 alkoxy; C 1 to C 6 alkanoyloxy; C 2 to C 6 alkenyloxy; phenyl -C 1 to C 6 alkoxy; phenoxy; C 2 to C 6 alkenoyloxy or phenyl -C 1 to C 6 alkanoyloxy; or C 3 to C 6 cyeloalkyloxy which is substituted with one group selected from carboxy, esterified carboxy and amidated carboxy; or aminooxy; R 5 is hydrogen or hydroxy group; R 6 and R 7 are each independently hydrogen; C 1 to C 6 alkyl which is unsubstituted or substituted with one group selected from hydroxy, C 1 to C 6 alkoxy, pyridine and phenyl; benzyl; pyridinyl; carbonyl which is unsubstituted or substituted with one group selected from C 1 to C 6 alkyl, hydroxy, C 1 to C 6 alkoxy, phenyl, benzyl, pyridine and or C 1 to C 6 alkanesulfonyl; R 8 and R 9 are each independently hydrogen; C 1 to C 6 alkyl which is unsubstituted or substituted with one group selected from hydroxy, C 1 to C 6 alkoxy, morpholine, imidazole and NR 6 R 7 ; C 1 to C 6 alkoxy; C 3 to C 6 cycloalkyl; phenyl; benzyl; pyridinyl; morpholine; carbonyl which is unsubstituted or substituted with one group selected from C 1 to C 6 alkyl, C 1 to C 6 alkoxy, phenyl, benzyl, pyridine and carbonyl substituted with C 1 to C 6 alkyl which is substituted with one group selected from halogen, C 1 to C 6 alkoxy and imidazole; or C 1 to C 6 alkanesulfonyl; R 10 and R 11 are each independently hydrogen, C 1 to C 2 alkyl, C 1 to C 3 alkoxy or halide; X 1 and X 3 are each independently O; S; NH; or N—C 1 to C 6 alkyl, N—C 3 to C 6 cycloalkyl, N-benzyl or N-phenyl; X 2 is C 3 to C 7 alkylene; C 1 to C 3 alkylene-C 2 to C 7 alkenylene-C 1 to C 3 alkylene; C 1 to C 3 alkylene-O—C 1 to C 3 alkylene; C 1 to C 3 alkylene-S—C 1 to C 3 alkylene; C 1 to C 3 alkylene-NH—C 1 to C 3 alkylene; C 1 to C 3 alkylene -phenylene-C 1 -C 3 alkylene; C 1 -C 3 alkylene-pyridylene-C 1 -C 3 alkylene or C 1 -C 3 alkylene -naphthylene-C 1 to C 3 alkylene; C 3 to C 7 alkylene which is substituted with C 1 to C 3 alkyl and hydroxyl; C 3 to C 7 alkylene carbonyl; or C 3 to C 7 alkylene which is interrupted by piperazine; Y is O, S, NR 6 or CH 2 ; Q is CH 2 or carbonyl; and n is an integer of 0 to 6, or a pharmaceutically acceptable salt thereof.