Patent ID: 8394816

Claim:
A method of treating resistant Waldenstrom's Macroglobulinemia comprising administering to an animal a compound having the structure of Formula I, or a pharmaceutically acceptable salt or pro-drug ester thereof: wherein R 1 , R 3 , and R 4 are separately selected from the group consisting of a hydrogen, a halogen, a mono-substituted, a poly-substituted or an unsubstituted moiety of the following residues: saturated C 1 -C 24 alkyl, unsaturated C 2 -C 24 alkenyl or C 2 -C 24 alkynyl, acyl, acyloxy, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, amino, aminocarbonyl, aminocarboyloxy, nitro, azido, phenyl, cycloalkylacyl, hydroxy, alkylthio, arylthio, oxysulfonyl, carboxy, cyano, thio, sulfoxide, sulfone, sulfonate esters, thiocyano, boronic acids and esters, and halogenated alkyl including polyhalogenated alkyl; wherein m is equal to 1 or 2; wherein n is equal to 1 or 2; wherein each of E 1 , E 2 , E 3 and E 4 is a substituted or unsubstituted heteroatom; and wherein E 5 is selected from the group consisting of OH, O, OR 10 , S, SR 11 , SO 2 R 11 , NH, NH 2 , NOH, NHOH, NR 12 , and NHOR 13 .