Patent ID: 7906536

Claim:
A process for preparing (−)-3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide, or a pharmaceutically acceptable salt thereof comprising the steps: a) contacting a compound of formula V: with a brominating reagent in the presence of at least one solvent to produce a compound of Formula IV: b) contacting a compound of Formula IV with a hydrolase in the presence of a buffer solution to produce a compond of Formula X: c) contacting a compound of Formula X with an activating reagent in the presence of at least one solvent and then contacting the resulting mixture with methylamine to produce a compound of Formula IX: d) contacting a compound of Formula IX with a 2,4-difluorobenzylhalide in the presence of a base and at least one solvent; wherein R 1 is a C 1 -C 6 alkyl or aryl.