Patent ID: 7232842

Claim:
A compound having the structure of formula (Ia) wherein: m is zero, 1, 2, 3, 4, or 5, and n is zero, 1, 2, 3, 4, or 5, and the sum of m and n is in the range of 2 to 5 inclusive; R 1 is H or lower alkyl; R 2 is H, a heteroatom-protecting group, or -L-NR 7 R 8 wherein L is a linker containing 1 to 6 spacer atoms, and R 7 and R 8 are independently selected from hydrogen, nitrogen-protecting groups, C 1 –C 24 hydrocarbyl, substituted C 1 –C 24 hydrocarbyl, heteroatom-containing C 1 –C 24 hydrocarbyl, and substituted heteroatom-containing C 1 –C 24 hydrocarbyl; R 3 and R 4 are independently selected from hydrogen, C 1 –C 24 hydrocarbyl, substituted C 1 –C 24 hydrocarbyl, heteroatom-containing C 1 –C 24 hydrocarbyl, and substituted heteroatom-containing C 1 –C 24 hydrocarbyl, or R 3 and R 4 taken together form a heterocyclic ring optionally fused to an additional cyclic group; R 5 is a substituent selected from hydrogen, C 1 –C 24 hydrocarbyl, substituted C 1 –C 24 hydrocarbyl, heteroatom-containing C 1 –C 24 hydrocarbyl, or substituted heteroatom-containing C 1 –C 24 hydrocarbyl; R 6 is a substituent selected from hydrogen, halo, hydroxyl, sulfhydryl, C 1 –C 24 alkoxy, C 2 –C 24 alkenyloxy, C 2 –C 24 alkynyloxy, C 5 –C 24 aryloxy, C 2 –C 24 alkylcarbonyl, C 6 –C 24 arylcarbonyl, C 2 –C 24 alkylcarbonyloxy, C 6 –C 24 arylcarbonyloxy, halocarbonyl, C 2 –C 24 alkylcarbonato, C 6 –C 24 arylcarbonato, carboxy, carboxylato, carbamoyl, mono-(C 1 –C 24 alkyl)-substituted carbamoyl, di-(C 1 –C 24 alkyl)-substituted carbamoyl, mono-(C 6 –C 24 aryl)-substituted carbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, isothiocyanato, azido, formyl, thioformyl, amino, mono-(C 1 –C 24 alkyl)-substituted amino, di-(C 1 –C 24 alkyl)-substituted amino, mono-(C 5 –C 24 aryl)-substituted amino, di-(C 5 –C 24 aryl)-substituted amino, C 2 –C 24 alkylamido, C 6 –C 24 arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C 1 –C 24 alkylthio, C 5 –C 24 arylthio, C 1 –C 24 alkylsulfinyl, C 5 –C 24 arylsulfinyl, C 1 –C 24 alkylsulfonyl, C 5 –C 24 arylsulfonyl, phosphono, phosphonato, phosphinato, phosphono, phosphino, C 1 –C 24 alkyl, C 2 –C 24 alkenyl, C 2 –C 24 alkynyl, C 5 –C 24 aryl, C 6 –C 24 alkaryl, and C 6 –C 24 aralkyl, wherein any of the foregoing substituents, if the substituent permits, may be further substituted, or wherein R 5 and R 6 taken together form ═O, ═S, or ═NR 9 where R 9 is selected from hydrogen, C 1 –C 24 hydrocarbyl, substituted C 1 –C 24 hydrocarbyl, heteroatom-containing C 1 –C 24 hydrocarbyl, and substituted heteroatom-containing C 1 –C 24 hydrocarbyl, or a pharmaceutically acceptable, pharmacologically active salt thereof.