Patent ID: 7241794

Claim:
A compound according to formula I wherein R 1 is selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-7 cycloalkyl, C 1-3 alkoxy-C 1-3 alkyl, phenyl and benzyl, wherein, said phenyl and said benzyl optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 -haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylthio, nitro, halogen and cyano; R 2 is phenyl optionally substituted with one to three groups independently selected from the group consisting of halogen, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxycarbonyl, and CONR 6 R 7 ; R 3 is substituted C 1-6 alkyl, substituted C 1-3 alkoxy-C 1-3 alkyl, substituted C 3-6 alkenyl, C 3-7 cycloalkyl, optionally substituted C 1-6 alkoxy, (CH 2 ) n R 5 , CH(OH)R 5 , —(CH 2 ) o —O—(CH 2 ) p R 5 , NR 6 R 7 , C(═Y)Z or —X(C═Y)Z; wherein, said alkyl, said C 1-3 alkoxy-C 1-3 alkyl and said alkenyl are substituted by —OH, —NR 6 R 7 , —C(═Y)Z, —X(C—Y)Z, CN, —S(O) q —C 1-6 alkyl; —SO 2 NR 6 R 7 , —SO 2 NHNH 2 , or —NR 6 SO 2 —C 1-6 alkyl; said alkoxy is optionally substituted by —OH, —NR 6 R 7 , —C(═Y)Z, —X(C═Y)Z, —S(O) q —C 1-6 alkyl; —SO 2 NR 6 R 7 or —SO 2 NHNH 2 ; R 3 is a phenyl optionally substituted with halo,—OR 6 , —NR 6 R 7 , —C(═O)Z, —X(C═O)Z; wherein R 4 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl; wherein, said alkyl, said alkenyl and said alkynyl are optionally substituted by —OH, —OR 6 , —NR 8 R 9 , —C(═Y)Z, —X(C═Y)Z, —S(O) q —C 1-6 alkyl, —SO 2 or —SO 2 NHNH 2 ; n, o, p and q are as defined below; R 6 , R 7 , R 8 and R 9 taken independently are selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-3 alkoxy-C 1-3 alkyl C 1-3 alkylamino-C 1-3 alkyl and C 1-3 dialkylamino-C 1-3 alkyl X, and Y are independently O or NR 6 ; Z is hydrogen, hydroxyl, C 1-6 alkoxy, NR 6 R 13 , C 1-6 alkyl, C 1-3 alkoxy-C 1-3 alkyl wherein R 13 is R 7 or phenyl optionally substituted with one to three groups independently selected from the group consisting of halogen, cyano, C 1-3 alkyl, C 1-3 haloalkyl and C 1-3 alkoxy; n is 0 to 3; o and p are independently 0 to 4 and o+p≦5; q is 0 to 2; and, acid addition salts, hydrates and solvates thereof.