Patent ID: 6962925

Claim:
A benzo(c)quinolizine compound of formula (1): wherein: R 1 , R 2 , R 3 , R 4 and R 6 , which are the same or different, are chosen from the group consisting of: H, CN, COOR, CONRR′, C(═O)R, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, norbornane, camphane, adamantane, phenyl, biphenyl, naphthyl, or naphthyl-C 1-8 ; R 5 is chosen from the group consisting of: H, C 1-8 alkyl, C 1-8 alkyl-phenyl, biphenyl, naphthyl, COOR, CN or phenyl; X is chosen from the group consisting of: O, C(═O)R, COOR, NO 2 , and CONRR′, wherein R and R′ are the same or different and are chosen from the group consisting of H, C 1-8 alkyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, norborane, camphane, adamantane, phenyl, biphenyl, napthyl; Q is chosen from the group consisting of single-bond, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, norbornane, canphane, adamantane, CO, CONR, and NR, where R is as above defined; W is chosen from the group consisting of H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, norbornane, canphane, adamantane, trifluoromethyl, C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, phenyl, biphenyl, naphthyl-C 1-8 alkyl, phenyl, biphenyl, naphthyl, phenyloxy, biphenyloxy, naphthyloxy, phenylamino, biphenylamino, naphthylamino, C 1-8 alkyl-carbonyl, phenylcarbonyl, biphenylcarbonyl, naphthylcarbonyl, phenylcarboxyl, biphenylcarboxyl, naphthylcarboxyl, phenylcarboxyamide, biphenylcarboxyamide, naphthylcarboxyamide, halogen, CN, NRR′, C 1-8 alkylamino; n is an integer of 1 to 4; the symbol ------- means that the corresponding bonds a, b, c, d, e, f, g, h and i are single or double bonds, with the proviso that when b or f are a double bond, the group R 5 is absent; or a pharmaceutical acceptable salt thereof.