Patent ID: 8008316

Claim:
A compound of Formula I: wherein n is 1-8; p is 2-4; X is —(CH 2 ) q NH-A, —(CH 2 ) q NH-A-B, —(CH 2 ) q NH-A-W—B, -A, -A-B, -A-W—B, -W-A, —W-A-B, or —W-A-W—B, wherein A is a peptide comprising two or more amino acids, B is a cell-targeting construct, W is a coupling moiety selected from the group consisting of —(CH 2 ) m NH—, —C(O)(CH 2 ) m C(O)—, —C(O)(CH 2 ) m —, and m is 1-16 and q is 1-8; Z is hydrogen, methyl, or, when n is 2 and R 2 is —(CH 2 ) 2 —, Z is a bond between R 2 and the nitrogen to which Z is attached; R 1 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkynoyl, alkylthiol, formyl, halogen, aryl, nitro, sulfanyl, hydrazino, amino, oxyamino, alkylamino, dialkylamino, and combinations thereof; and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkynoyl, alkylthiol, formyl, halogen, aryl, nitro, sulfanyl, hydrazino, amino, oxyamino, alkylamino, dialkylamino, and combinations thereof, or R 2 is —(CH 2 ) 2 —.