Patent ID: 6969730

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt, ester, or amide thereof, wherein A is a covalent bond; D is O; L is selected from the group consisting of lower alkylene, fluoroalkylene, and hydroxyalkylene; P and Q taken together form a covalent bond or are both hydrogen; R 1 and R 2 are each independently selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocyclealkyl, hydroxyalkyl, alkenyl, and alkynyl; or R 1 and R 2 taken together with the nitrogen atom to which they are attached, together form a heterocycle; R 3 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfinyl, alkylsulfonyl, alkylthio, aryl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, halogen, haloalkoxy, haloalkyl, heterocycle, hydroxy, hydroxyalkyl, mercapto, nitro, â€”NR A R B , (NR A R B )alkyl, (NR A R B )carbonyl, and (NR A R B )sulfonyl; R 4 , R 5 , R 6 and R 7 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfinyl, alkylsulfonyl, alkylthio, aryl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, formyl, halogen, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, mercapto, nitro, â€”NR A R B , (NR A R B )alkyl, (NR A R B )carbonyl, (NR A R B )sulfonyl, â€”L 2 R 20 , and â€”R 20 L 3 R 22 ; L 2 is selected from the group consisting of alkylene, alkenylene, O, S, S(O), S(O) 2 , C(â•O), Câ•(NOR 21 ), and N(R A ); L 3 is selected from the group consisting of a covalent bond, alkylene, alkenylene, O, S, C(â•O), N(â•OR 21 ), and N(R A ) R 20 is selected from the group consisting of aryl, heterocycle, and cycloalkyl; R 21 is selected from the group consisting of hydrogen and alkyl; R 22 is selected from the group consisting of aryl, heterocycle, and cycloalkyl; R A and R B are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl and formyl; provided that at least one of R 4 , R 5 , R 6 , or R 7 is aryl, cycloalkyl, â€”L 2 R 20 or â€”R 20 L 3 R 22 .