Patent ID: 7432392

Claim:
An ester compound of the formula (1): wherein R 1 is hydrogen or C 1 -C 6 alkyl; ring A is phenyl; X is —CON(R 10 )—(CH 2 ) n — (wherein R 10 is hydrogen, C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl, and n is 0 or an integer of 1 to 3); R 2 is optionally substituted phenyl; R 3 , R 4 and R 200 are each independently hydrogen, hydroxy, halogen, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo-C 1 -C 6 alkyl, C 1 -C 6 acyl, C 3 -C 10 alkoxycarbonylalkyl, —CON(R 11 )(R 12 ) (wherein R 11 and R 12 are each independently hydrogen, optionally substituted C 1 -C 6 alkyl or C 1 -C 6 alkoxy, or R 11 and R 12 taken together with the nitrogen atom to which they are attached may form (wherein R 0 is hydrogen and p is 0)); —(CH 2 ) q′ —N(R 13 )(R 14 ) (wherein R 13 and R 14 are each independently hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkoxycarbonyl; or C 1 -C 6 acyl; or R 13 and R 14 taken together with the nitrogen atom to which they are attached may form (wherein p has the same meaning as defined above) and q′ is 0 or an integer of 1 to 3)); —CO—(R 15 ) (wherein R 15 is hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, optionally substituted C 6 -C 14 aryloxy or C 7 -C 16 aralkyloxy); or —(CH 2 ) r′ —O—CO—R 100′ (wherein R 100′ is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 12 alkoxyalkyl or —N(R 40 )(R 41 ) (wherein R 40 and R 41 are each independently hydrogen, C 1 -C 6 alkyl or optionally substituted C 6 -C 14 aryl, and r′ is 0 or an integer of 1 to 3)); ring B is Alk 1 is methylene; Alk 2 is methylene; l is 0 or an integer of 1 to 3; m is 0 or an integer of 1 to 3; ring C is R 5 , R 6 and R 7 are each independently hydrogen or C 1 -C 6 alkyl; R 8 and R 9 are each independently hydrogen or C 1 -C 6 alkyl; E is —O— or —N(R 90 )— wherein R 90 is hydrogen or C 1 -C 6 alkyl; and Y is —O—CO—O—, —O—CO—, —CO—O—, —CO—O—C(R 110 )(R 111 )—O—CO—, —CO—O—C(R 110 )(R 111 )—O—CO—O—, —O—CO—O—C(R 110 )(R 111 )—O—CO—, —O—CO—C(R 110 )(R 111 )—O—, —O—CO—C(R 110 )(R 111 )—C(R 110 )(R 111 )—O— or —O—C(R 110 )(R 111 )—CO—O— (wherein R 110 and R 111 are each independently hydrogen or C 1 -C 6 alkyl), provided that when Y is —CO—O—, then R 3 is —(CH 2 ) r′ —O—CO—R 100′ wherein R 100′ and r′ each has the same meaning as defined above; or a pharmaceutically acceptable salt thereof.