Patent ID: 6878715

Claim:
A therapeutic compound, including resolved enantiomers, diastereomers, tautomers, salts and solvates thereof, having the following formula (I): wherein: X is N(R 3 ), Y is NH or N(CH 3 ) and Z is C(R 4 ), where R 3 is H, CH 3 or CH 2 OCH 2 CH 3 , and R 4 is selected from the group consisting of C (1-20) alkylamino, C (1-20) alkylaminoalkyl, C (1-20) aminoalkyl, C (1-20) aminoalkoxyalkenyl, C (1-20) aminoalkoxyalkenyl, C (1-20) diaminoalkyl, C (1-20) triaminoalkyl, C (1-20) tetraaminoalkyl, C (5-15) aminotrialkoxyamino, C (1-20) alkylamido, C (1-20) alkylamidoalkyl, C (1-20) amidoalkyl, C (1-20) acetamidoalkyl; R 1 is —(CH 2 ) n —CHOH—CH 3 which may be substituted with a member of the group consisting of acylamino and —NR a R b , wherein each of R a and R b may be the same or different and each is selected from the group consisting of hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl and heterocyclic group; and n is 3-7; and R 2 is hydrogen or methyl and the dot line represent a single bond or double bond.