Patent ID: 8563288

Claim:
A method for specifically removing or isolating plasminogen or plasmin from a mixture plasma derived cryoprecipitate containing plasminogen or plasmin in the presence of fibrinogen and fibronectin comprising contacting the plasma derived cryoprecipitate with an amino acid having a rigid constitution, wherein the distance between the amino group and the carboxylic group of the amino acid is kept substantially constant by the rigid constitution of the amino acid, wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms apart, and wherein the amino acid is covalently bound to a support via the amino group of the amino acid, such that the plasminogen or plasmin binds to amino acid bound to the support, followed by separating the support-bound plasminogen or plasmin from the plasma derived cryoprecipitate.