Patent ID: 8431570

Claim:
A method of treating psychoses, schizophrenia, acute mania, bipolar disorder, autistic disorder or depression, the method comprising administering to a patient in need thereof a compound of Formula 1: or a pharmaceutically acceptable salt, isomer, racemate, or diastereomeric mixture thereof, wherein: A is —O—(CH 2 ) n —, —S—(CH 2 ) n —, —CH 2 —O—(CH 2 ) n —, —(CH 2 ) n —O—CH 2 —CH 2 —, —CH 2 —S—(CH 2 ) n —, —(CH 2 ) n —S—CH 2 —CH 2 , —NH—C(O)—(CH 2 ) n —, —CH 2 —C(O)—NH—(CH 2 ) n —, —(CH 2 ) n —C(O)—NH—CH 2 —CH 2 —, or —CH 2 —NH—C(O)—(CH 2 ) n —, wherein n is an integer from 1 to 7; B is O; and R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , and R 8 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, heteroaryl, heteroarylalkyl, acylalkyloxycarbonyl, acyloxyalkyloxycarbonyl, acylalkyloxycarbonylamino, acyloxyalkyloxycarbonylamino, alkoxy, alkoxycarbonyl, alkoxycarbonylalkoxy, alkoxycarbonyllalkylamino, alkylsulfinyl, alkylsulfonyl, alkylthio, amino, alkylamino, arylalkylamino, dialkylamino, arylalkoxy, arylalkoxycarbonylalkoxy, arylalkoxycarbonylalkylamino, aryloxycarbonyl, aryloxycarbonylalkoxy, aryloxycarbonylalkylamino, carboxy, carbamoyl, carbamate, carbonate, cyano, halogen, heteroaryloxycarbonyl, hydroxy, phosphate, phosphonate, sulfate, sulfonate, or sulfonamide; wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 and R 8 and A are optionally substituted with isotopes selected from the group consisting of 2 H (deuterium), 3 H (tritium), 13 C, 36 Cl, 18 F, 15 N, 17 O, 18 O, and 35 S.