Patent ID: 7829530

Claim:
A method for treating type II diabetes in an animal, comprising conjointly administering to the animal (i) metformin, and (ii) an inhibitor of dipeptidylpeptidase IV represented in the general formula: or a pharmaceutically acceptable salt thereof, wherein R 1 represents a C-terminally linked amino acid residue or amino acid analog, or a C-terminally linked peptide or peptide analog, or R 6 represents hydrogen, a halogen, an alkyl, an alkenyl, an alkynyl, an aryl, —(CH 2 ) m —R 7 , —(CH 2 ) m —OH, —(CH 2 ) m -O-alkyl, —(CH 2 ) m —O-alkenyl, —(CH 2 ) m —O-alkynyl, —(CH 2 ) m —O—(CH 2 ) m —R 7 , —(CH 2 ) m —SH, —(CH 2 ) m —S-alkyl, —(CH 2 ) m —S-alkenyl, —(CH 2 ) m —S-alkynyl, —(CH 2 ) m —S—(CH 2 ) m —R 7 , R 7 represents an aryl, a cycloalkyl, a cycloalkenyl, or a heterocycle; R 8 and R 9 each independently represent hydrogen, alkyl, alkenyl, —(CH 2 ) m —R 7 , —C(═O)-alkyl, —C(═O)-alkenyl, —C(═O)-alkynyl, —C(═O)—(CH 2 ), —R 7 , or R 8 and R 9 taken together with the N atom to which they are attached complete a heterocyclic ring having from 4 to 8 atoms in the ring structure; R 11 and R 12 each independently represent hydrogen, an alkyl, or a pharmaceutically acceptable salt, or R 11 and R 12 taken together with the O—B—O atoms to which they are attached complete a heterocyclic ring having from 5 to 8 atoms in the ring structure; m is zero or an integer in the range of 1 to 8; and n is an integer in the range of 1 to 8, and wherein the inhibitor inhibits dipeptidylpeptidase proteolysis of GLP-1 with a Ki of less than about 10 nM, wherein the metformin and inhibitor are administered in an amount sufficient to treat Type II diabetes but not sufficient to suppress the immune system of the animal.