Patent ID: 6979691

Claim:
A compound according to the formula or a pharmaceutically-acceptable salt or hydrate thereof, in which, K is aryl or heteroaryl; R 8 and R 9 are independently alkyl substituted with heteroaryl, cycloalkyl, aryl, and, —C(═O)R 13 ; R 11 is selected from hydrogen, alkyl, halogen, hydroxy, hydroxyalkyl, haloalkyl, amino, aminoalkyl, alkylamino, arylalkyl, cyctoalkylalkyl, heteroarylalkyl, aryl, and cycloalkyl, and where y is at least 1, then R 11 may be heterocyclo or heterocycloalkyl; R 13 is alkyl; W is selected from: 1) —NR 16 R 17 , —NR 16 C(═O)R 22 , —NR 18 CO 2 R 22 , —OR 23 , amidino, and guanidino; 2) heteroaryl or heterocyclo groups selected from pyrrolyl, furyl, thienyl, imidazolyl, pyrazolyl, isoxazolyl, thiazolyl, isothiazolyl, 3-azaisothiazolyl, pyridyl, pyrazinyl, pyridazinyl, 1,2-dihydropyridazinyl, and pyranyl, wherein said heteroaryl and heterocyclo groups may be substituted or unsubstituted and may have an optionally-substituted carbocyclic, heterocyclic or heteraryl ring fused thereto; or 3) a ring selected from: R 16 and R 17 are selected from hydrogen, alkyl and substituted alkyl; R 18 , R 19 and R 21 are independently hydrogen or C 1-6 alkyl optionally substituted with halogen; R 20 is C 1-6 alkyl, aryl, or heteroaryl; R 22 and R 23 are independently selected from hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclo; R 24 and R 25 at each occurrence are attached to any available carbon or nitrogen atom of W and at each occurrence are selected from hydrogen, C 1-6 alkyl, halogen, substituted C 1-6 alkyl, amino, alkylamino, cyano, nitro, trifluoromethoxy, —C(═O)R 26 , —CO 2 R 26 , —SO 2 R 26 , —OR 26 , aryl, heteroaryl, heterocyclo, and cycloalkyl, and/or two R 25 attached to two adjacent carbon atoms or adjacent carbon and nitrogen or carbon atoms may join to form a fused optionally-substituted heteroaryl, heterocyclo or cycloalkyl ring, and/or two R 24 or two R 25 when attached to the same carbon atom may form keto (═O); R 26 is hydrogen, alkyl, substituted alkyl, aryl, heterocyclo, cycloalkyl, or heteroaryl, except when joined to a sulphonyl group as in SO 2 R 26 , then R 26 is not hydrogen; R 30 is attached to any available carbon or nitrogen atom of K and is selected from C 1-4 alkyl, hydroxy, alkoxy, halogen, nitro, cyano, amino, alkylamino, phenyl, and —C(═O)phenyl; and k and m are independently 0, 1, 2 or 3; p is 1, 2, or 3; t is 0, 1 or 2, u and v are 0, 1, 2, or 3; w is 0, 1, or 2; y is 0, 1, 2, 3, or 4; and z is 0, 1 or 2.