Patent ID: 8747847

Claim:
A method of treating a tumor or enhancing survival of a subject having a tumor, the method comprising (i) administering to a subject in need thereof an effective amount of a humanized monoclonal antibody BAT (mBAT-1) or a fragment thereof, wherein the antibody or the fragment thereof has all complementarity determining regions of mBAT-1 and a framework region (FR) from an acceptor human immunoglobulin, or modified therefrom; and (ii) administering to the subject an effective amount of at least one chemotherapeutic agent selected from the group consisting of 5-fluorouracil, cytarabine, oxaliplatin, paclitaxel and combinations thereof, and the humanized antibody is administered between 1 and 30 days prior to commencing chemotherapy; thereby treating the tumor or enhancing survival of the subject having the tumor.