Patent ID: 8436038

Claim:
An indole compound of the following formula (1): in which n denotes a number of 1 to 3, m denotes 0 or 1, A represents phenyl, X represents C or CH, with the proviso that m is 1 when X is C, R 1 represent hydrogen, alkyl, —(CH 2 ) r NR 7 R 8 , or —(CH 2 ) r CO 2 H, wherein r denotes a number of 1 to 5, and R 7 and R 8 independently of one another represent hydrogen, alkyl or alkylcarbonyl, or may together form an optionally alkyl-substituted alkylene chain wherein optionally one methylene is replaced by N atom, R 2 represents hydrogen, halogen, cyano, nitro, hydroxy, alkyl, alkoxy or trialkylsilyl, represents —(CH 2 ) p CO 2 R 7 , —(CH 2 ) p OR 7 , —(CH 2 ) p NR 7 R 8 , —NHR 10 , —N(H)S(O) 2 R 7 , —NHC(O)R 10 , —(CH 2 ) p S(O) 2 R 7 or (CH 2 ) p -heterocycle-R 10 , wherein p denotes a number of 0 to 3, R 7 and R 8 are as defined above, R 10 represents hydrogen, oxo, alkylsulfonyl, alkylcarbonyl, alkyloxycarbonyl, alkylaminocarbonyl, alkoxy, alkyl or heterocycle, R 3 represents hydrogen, cyano, halogen, alkyl or phenyl, or represents —(CH 2 ) n -heterocycle or —(CH 2 ) n -aryl, wherein n denotes a number of 0 to 3, R 4 represents —YR 11 , wherein Y represents a direct bond or —(CR 7 R 8 ) p Y′—, wherein p denotes a number of 0 to 3, R 7 and R 8 are as defined above, Y′ is selected from the group consisting of —O—, —S—, —NR 12 —, —NR 12 C(O)—, —C(O)—, —C(O)O—, —C(O)NR 12 —, —S(O) q —, and —S(O) q NR 12 —, wherein R 12 represents hydrogen, alkyl, aryl or heteroaryl, q denotes a number of 0 to 2, R 11 is selected from the group consisting of hydrogen, cyano, halogen, hydroxy, thiol, carboxy, alkyl and —(CH 2 ) t B—R 13 , wherein t denotes a number of 0 to 3, B represents heterocycle, heteroaryl or aryl, R 13 represents hydrogen, cyano, halogen, hydroxy, oxo, thiol, carboxy, carboxyalkyl, alkylcarbonyloxy, alkyl, alkoxy, alkylthio, alkylcarbonyl or alkylsulfonyl, R 5 represents hydrogen, alkyl, cycloalkyl, heterocycle or heterocyclylalkyl, R 6 represents —(CR 7 R 8 ) p —Z-D-W—R 14 , wherein Z represents a direct bond, or is selected from the group consisting of —C(O)—, —C(O)O—, —C(O)NR 12 —, and —S(O) y —, y denotes a number of 1 or 2, D represents a direct bond, or represents cycloalkyl, heteroaryl or heterocycle, W represents a direct bond, or represents —NR 7 —, —C(O)—, —C(O)O—, —C(O)NR 12 —, —S(O) y —, —S(O) y NR 12 — or —NR 12 S(O) y —, wherein R 14 represents hydrogen, hydroxy, alkyl, alkoxy, heterocycle, heteroaryl, aryl or aralkyl, R 5 and R 6 together represent alkylene chain, where alkyl, alkoxy, aryl, cycloalkyl, heterocycle and heteroaryl may be optionally substituted, and the substituents are one or more selected from the group consisting of hydroxy, halogen, nitrile, amino, alkylamino, dialkylamino, carboxy, alkyl, alkoxy, carboxyalkyl, alkylcarbonyloxy, alkylthio, alkyloxycarbonyl, alkylaminocarbonyl, arylalkoxy and oxo, provided that R 3 is phenyl when X is CH, and provided that R 6 is not hydrogen when X is C, or a pharmaceutically acceptable salt or a stereoisomer or geometric isomer thereof.