Patent ID: 7435731

Claim:
A compound of the formula Ia; or a pharmaceutically acceptable salt thereof, wherein: R 1 is 2-halophenyl or 2,4-dihalophenyl; R 2 is 2-chlorophenyl, 4-hydroxyphenyl, 4methoxyphenyl, 4-benzyloxyphenyl, 3-benzyloxyphenyl, 4-dimethylaminophenyl, 4-aminophenyl, 4-fluorophenyl, 3-fluorophenyl, 2-fluorophenyl, 3-trifluoromethylphenyl, pyrid-3-yl, 4-(pyrid-2-yl)phenyl, 3-isopropoxyphenyl, 3,5-dimethylphenyl, 1,3-benzodioxol-5-yl, 3-morpholinophenyl, 4-morpholinophenyl, 3-(4-methyl-piperazin-1-yl)-phenyl, 4-(4-methyl-piperazin-1-yl)-phenyl, N-methyl-N-(2-methoxyethyl)-phenyl, 2,4-difluorophenyl, 4-isopropyloxyphenyl, 3-(2-pyridin-2-yl-ethoxy)-phenyl, or thien-2-yl; R 3 is hydrogen or alkyl; R 4 is hydrogen, alkyl, heteroalkyl, heterocyclyl, hydroxycycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, —C(═O)—R b ,or —SO 2 —R b ; wherein R b is alkyl, heteroalkyl, aryl, aralkyl, heteroaryl, or heterocyclyl; X and Y are nitrogen; W is O, S(O) m , CH 2 or NR f , wherein m is from 0 to 2, and R f is hydrogen, alkyl, heteroalkyl, heterocyclyl, hydroxycycloalkyl, —C(═O)—R g or —SO 2 —R g , wherein R g is alkyl, aryl, aralkyl, heteroaryl, heteroalkyl or heterocyclyl; A is O or S; k is 0 or 1 B is O, S(O) j , CH(OR i ), NR j , or C(═O), wherein j is 0, 1 or 2; R i is hydrogen or alkyl, R j is hydrogen, alkyl, —C(═O)—R k , or —SO 2 R m , wherein R k is alkyl, aryl or aralkyl; and R m is alkyl.