Patent ID: 7553971

Claim:
A process for preparing a compound of formula (II): wherein: R 4 is —CH 2 OH or —NHCHO and R 5 is hydrogen; or R 4 and R 5 taken together are —NHC(═O)CH═CH—; R 11 is phenyl, wherein each phenyl is optionally substituted with 1 or 2 substituents selected from halo, —OR d , —CN, —NO 2 , —SO 2 R d , —C(═O)R d , —C(═O)NR d R e , and C 1-3 alkyl, wherein C 1-3 alkyl is optionally substituted with 1 or 2 substituents selected from carboxy, hydroxy, and amino, and each R d and R e is independently hydrogen or C 1-3 alkyl; or R 11 is selected from pyridyl, thiophenyl, furanyl, pyrrolyl, isoxazolyl, and indolyl, each of which is optionally substituted with 1 or 2 C 1-3 alkyl substituents; and R 12 is hydrogen or —OC 1-6 alkyl; or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof, the process comprising: (a) deprotecting a compound of formula (III′) wherein Pg 1 is a hydroxy-protecting group and R 15 is hydrogen or Pg 3 , wherein Pg 3 is an amino-protecting group; (b) reacting a compound of formula (IV′): wherein R 16 is hydrogen or Pg 2 , wherein Pg 2 is a hydroxy-protecting group, and X is a leaving group, with a compound of formula (V′): in the presence of a transition metal catalyst; (c) reacting a compound of formula (VII′): wherein R 14 is hydrogen, with a compound of formula (VI′) wherein Z is a leaving group; or (d) reacting a compound of formula (VII′) with a compound of formula (VIII′) wherein R 4a is R 4 or a precursor to R 4 , and then, when R 4a is a precursor, converting the precursor to R 4 ; and optionally removing any protecting groups to provide a compound of formula (II) or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.