Patent ID: 7407649

Claim:
A compound of formula (I) or formula (II) wherein D is —(CH 2 ) n —, —C(═X)—, —O—, —S(O) m —, —C(═X)N(R e )—, —C(R b ) 2 —, —C(R b )═C(R b )—, —CH(R b )CH(R b )—; E is optionally present and is —(CH 2 ) n —, —N(R d )—, —(CH 2 ) n N(R d )— or —N(R d )(CH 2 ) n —; F is —C(═X)— or —N(R d )—; G is —(CH 2 ) n —, —N(R d )—, —(CH 2 ) n N(R d )— or —N(R d )(CH 2 ) n ; J is optionally present and is —O—, —N(R c )—, —C(═X)N(R c )—, —S(O) m —, —N(R c )S(O) m —, —S(O) m N(R c )— or —N(R e )—; K is optionally present and is alkylene optionally substituted with R b ; or K is cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene, any of which is optionally substituted with R a ; L is hydrogen, halogen, —N(R f ) 2 , cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heterocycloalkenyl or heteroaryl, any of which is optionally substituted with R a , —C(═X)OR d , —OH, —OR c , —C(═X)N(R b )(R c ), —S(O) m N(R b )(R C ) or —CN; each R a is the same or different and is hydrogen, halogen, alkyl, aryl, hydroxy, alkoxy, -alkoxy-(CH 2 ) n C(O) 2 R b , —O-aryl, —C(═X)R c , —NO 2 , —CN, —N(R c )C(═X)R c , —C(═X)N(R c ) 2 , —S(O) 2 N(R c ) 2 or —N(R e ) 2 ; each R b is the same or different and is hydrogen or alkyl; each R c is the same or different and is alkyl, cycloalkyl, -alkyl-aryl, -alkyl-cycloalkyl or aryl optionally substituted with R a ; each R d is the same or different and is hydrogen, alkyl or aryl optionally with R a ; each R e is the same or different and is hydrogen, alkyl; or R e is aryl or heteroaryl, either of which is optionally substituted with R a ; each R f is the same or different and is hydrogen or alkyl; or R f —N—R f taken together form heterocycloalkyl, heterocycloalkenyl or heteroaryl; each X is the same or different and is oxygen or sulphur; Y and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, —CN, —N(R d )C(═X)R c , —C(═X)N(R c )(R d ), —S(O) m —R c , —N(R c )(R d )S(O) 2 , —S(O) 2 N(R c )(R d ), —N(R e ) 2 , —Si(R c ) 3 , -alkyl-Si(R c ) 3 , aryl optionally substituted with R a or —O- aryl optionally substituted with R a ; Rings 1 and 2 are the same or different and are each arylene or heteroarylene, either of which is optionally substituted with R a ; each m is the same or different and is 0, 1 or 2; and each n is the same or different and is 0, 1, 2, or 3; with the provisos that at least one of Y and Z comprises a silicon atom and that the compound does not comprise a N—N single bond; or a pharmaceutically acceptable salt thereof.