Patent ID: 7608599

Claim:
A compound according to formula I wherein: R 1 is hydrogen or aryl wherein said aryl is phenyl or naphthyl optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, halogen, C 1-6 haloalkyl, —N(R 1a ) 2 , C 1-6 acylamino, —NHSO 2 C 1-6 alkyl, —SO 2 N(R 1a ) 2 , —SO 2 C 1-6 alkyl, COR 1b , nitro and cyano; R 1a is independently hydrogen or C 1-6 alkyl; R 1b is —OR 1a or —N(R 1a ) 2 ; R 2a and R 2b are (i) independently selected from the group consisting of hydrogen, C 1-10 alkyl, —(CH 2 ) r NR 1a 2 , C 1-6 hydroxyalkyl, —CH 2 SH, —(CH 2 ) 2 S(O) p Me, —(CH 2 ) 3 NHC(═NH)NH 2 , (1H-indol-3-yl)methyl, (1H-imidazol-4-yl)methyl, —(CH 2 ) m COR 1b , aryl and aryl C 1-3 alkyl, said aryl groups optionally substituted with a group selected from the group consisting of hydroxyl, C 1-10 alkyl, C 1-6 alkoxy, halogen, nitro and cyano,; (ii) R 2a is hydrogen and R 2b and R 4 together are (CH 2 ) 3 ; (iii) R 2a and R 2b together are (CH 2 ) n ; or, (iv) R 2a and R 2b both are C 1-6 alkyl; R 3 is hydrogen, C 1-10 alkyl, C 1-10 haloalkyl, aryl or aryl-C 1-3 alkyl wherein said aryl is phenyl; R 4 is hydrogen, C 1-3 alkyl, or R 2b and R 4 together are (CH 2 ) 3 ; R 5 is azide, C≡CH or -(Z)-CH═CHCl; R 6 is A, B, C or D wherein R 11 is hydrogen or C 1-3 alkyl; R 7 is hydrogen, methyl, halomethyl or halogen; either (a) R 9 is OR 8b and R 10 is hydrogen wherein R 8a and R 8b are (i) independently hydrogen, benzoyl or C 1-6 acyl or (i) together R 8a and R 8b are C(Me) 2 , C(CH 2 ) 4 , CHPh, or (b) R 9 is hydrogen and R 10 is OR 8b wherein R 8a and R 8b are independently hydrogen or C 1-6 acyl; m is 0 to 3; n is 4 or 5; p is 0 to 2; r is 1 to 6; and, pharmacologically acceptable salts thereof.