Patent ID: 7019135

Claim:
A compound having the formula: wherein: R is selected from the group consisting of optionally substituted C 5 to C 20 alkyl and optionally substituted C 5 to C 20 cycloalkyl, wherein said optional substituents are selected from the group consisting of OH, halogens, amino, CN, COOH, CO 2 R 1 , CONH 2 , CONHR 2 , OR 3 , SH, SR 4 , NO 2 , and aryl (5 to 10 ring atoms) optionally substituted with a member selected from the group consisting of OH, halogens, amino, CN, NO 2 , and C 1 to C 10 alkyl, which C 1 to C 10 alkyl moiety is optionally substituted with a member selected from the group consisting of OH, halogens, amino, CN, SH and NO 2 ; R′ is selected from the group consisting of hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyloxy, aryloxy, thiol, alkylthiol, arylthiol, and aryl; R″ is selected from the group consisting of hydrogen, alkyl, cycloalkyl, halogens, alkyloxy, aryloxy and aryl; R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of optionally substituted C 1 to C 5 alkyl, wherein said optional substituents are selected from the group consisting of OH, halogens, amino, CN, SH and NO 2 ; Q is selected from the group consisting of O, NH, S, N-alkyl and CY 2 , where Y may be the same or different and is selected from the group consisting of H, alkyl and halogens; X is selected from the group consisting of O, NH, S, Se, N-alkyl, (CH 2 ) n where n is 1 to 10, and CY 2 where Y may be the same or different and is selected from hydrogen, alkyl and halogens; Z is selected from the group consisting of O, S, NH, and N-alkyl; T is selected from the group consisting of H, halogens, alkyl (C 1 to C 10 ), O-alkyl (C 1 to C 10 ), N 3 and CN; T′ is selected from the group consisting of H, halogens, O-alkyl (C 1 to C 10 ), N 3 and CN; or T and T′ together form a bridge which is selected from the group consisting of —O—, —NH— and —(CH 2 ) p — wherein p is an integer from 1 to 6; T″ is selected from the group consisting of H, OH, halogens, N 3 and CN; T″′ is selected from the group consisting of H, OH, halogens, N 3 and CN; or T″ and T″′ together form a bridge which is selected from the group consisting of —O—, —NH— and —(CH 2 ) p — wherein p is an integer from 1 to 6; or T and T″′ together form ═CH 2 ; and W is selected from the group consisting of H, a phosphate group and a phosphonate group; and a pharmacologically acceptable salt, or pro-drug thereof.