Patent ID: 8889176

Claim:
A method of treating or managing pain comprising intranasally administering to an animal in need thereof in a single dosage regimen in an amount to effectively treat or manage pain, a pharmaceutical composition comprising an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof in an amount to effectively treat or manage pain and a pectin having a degree of esterification (DE value) of less than 30%, provided that the composition is substantially free of divalent metal ions; wherein the animal administered the composition is provided with a peak plasma concentration of fentanyl (C max ) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose; and wherein the intranasal administration of the composition provides a time to achieve peak plasma concentration (T max ) of fentanyl in the animal's plasma of 5 to 30 minutes.