Patent ID: 6995180

Claim:
A compound of the formula I: wherein: R 1 is selected from the group consisting of hydrogen (H), C 1 –C 6 alkyl, C 1 –C 6 alkenyl, C 1 –C 6 alkynyl, C 3 –C 8 cycloalkyl and C 3 –C 8 cycloalkenyl; R 2 is a substituted or unsubstituted functional group selected from the group consisting of C 1 –C 6 alkyl, C 3 –C 8 cycloalkyl, C 3 –C 8 cycloalkenyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl and arylalkynyl; R 3 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylthioalkyl, arylalkylthioalkyl, cycloalkenyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl and cycloheteroalkylalkyl, wherein any R 3 group may optionally be substituted through any available carbon atom with 1 to 5 substituents selected from the group consisting of hydrogen, halo, alkyl, polyhaloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroarylamino, —N(R 5 )Ar, cycloheteroalkyl, cycloheteroalkylalkyl, OR 5 , hydroxyalkyl, nitro, cyano, NR 5 R 5′ , alkylamino, thiol, alkylthio, alkylcarbonyl, acyl, alkoxycarbonyl, aminocarbonyl, alkynylaminocarbonyl, alkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyloxy, alkylcarbonylamino, arylcarbonylamino, alkylsulfonylamino, alkylaminocarbonylamino, alkoxycarbonylamino, alkylsulfonyl, aminosulfonyl, alkylsulfinyl, sulfonamido and sulfonyl; R 4 is hydrogen (H), or R 4 can be taken together with R 3 to form a substituted or unsubstituted 4 to 5 membered heterocyclic ring, preferably substituted by NR 5 R 5′ or C 1 –C 6 alkyl; and R 5 and R 5′ for each occurrence are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heterocycle and heteroaryl. including all prodrug esters, pharmaceutically acceptable salts and stereoisomers thereof.