Patent ID: 8492394

Claim:
A compound of Formula I wherein Q is NH; A and B are selected independently from CH and N with the proviso that A and B are not both N at the same time; R 1 and R 2 are independently C 1 -C 4 alkyl; R 3 , R 4 , R 5 , R 6 and R 7 are independently selected from the group consisting of: H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, halogen, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy(C 1-6 )alkyl, (C 1 -C 6 )hydroxycycloalkyl, (C 3 -C 8 )cycloalkoxy, (C 1 -C 6 )alkoxy(C 3 -C 8 )cycloalkyl, heterocycloalkyl, hydroxyheterocycloalkyl, and (C 1 -C 6 )alkoxy-heterocycloalkyl, wherein each (C 3 -C 8 )cycloalkyl or heterocycloalkyl moiety may be independently substituted with from one to three (C 1 -C 6 )alkyl; a —NR 8 R 9 group, wherein R 8 and R 9 are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, halo(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, and heterocycloalkyl; and a 6-7-membered aliphatic heterocycle: wherein n is 1 or 2 and Z is oxygen or NR 10 , wherein R 10 is selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, wherein Y is hydrogen or (C 1 -C 6 ) alkyl and X is selected from the group consisting of: a (C 1 -C 6 ) alkyl group unsubstituted or substituted with one or more halogens, —O—(C 1 -C 6 ) alkyl unsubstituted or substituted with one or more halogens, a —NR 11 R 12 group, where R 11 and R 12 are independently selected from hydrogen, C 1 -C 6 alkyl, halo(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, heterocycloalkyl, and a 6-7-membered aliphatic heterocycle: wherein n is 1 or 2; and W is oxygen or NR 13 , wherein R 13 is hydrogen or (C 1 -C 6 ) alkyl, or two adjacent substituents selected from R 3 , R 4 , R 5 , R 6 and R 7 may together with the aromatic ring they are attached to form a 5-7 membered, saturated or unsaturated ring containing carbon and one or two heteroatoms selected from N, O or S, and optionally substituted with an (C 1 -C 6 ) alkoxy group where the remaining three substituents selected from R 3 , R 4 , R 5 , R 6 and R 7 , which do not take part of the ring, are independently selected as stated above; or a pharmaceutically acceptable salt thereof.