Patent ID: 8263665

Claim:
A drug-loaded micelle comprising a triblock copolymer, wherein said micelle has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell, wherein the multiblock copolymer is of formula III: wherein: n is 10-2500; m is 5-50; m′ is 5-50; L is a metal crosslinked amino acid side-chain group; R y is a hydrophobic or ionic, natural or unnatural amino acid side-chain group; R 1 is —Z(CH 2 CH 2 Y) p (CH 2 ) t R 3 , wherein: Z is —O—; Y is —O—; p is 0-10; t is 0-10; and R 3 is optionally substituted aliphatic group; Q is a valence bond; R 2a is —NR 4 C(O)R 4 ; and each R 4 is independently hydrogen or an optionally substituted aliphatic.