Patent ID: 6934639

Claim:
A method for designing an agent that interacts with MMP-13, comprising: providing a composition including MMP-13: generating a three dimensional model of MMP-13; and utilizing the three dimensional model to design an agent that interacts with MMP-13, wherein the three dimensional model of MMP-13 includes relative structural coordinates of a plurality of atoms of MMP-13, and the relative structural coordinates are selected according to: FIGS. 4 and 4 A- 1 to 4 A- 32 , ± a root mean square deviation from the backbone atoms of amino acids of not more than 1.5 Å; or FIGS. 5 and 5 A- 1 to 5 A- 35 , ± a root mean square deviation from the backbone atoms of amino acids of not more than 1.5 Å.