Patent ID: 7935692

Claim:
A method to mobilize progenitor and/or stem cells to treat ischemia by effecting myocardial repair in a subject in need thereof which method comprises: administering to said subject a compound of the formula: Z-linker-Z′ (1) or a pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 2-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ is either embodied in a form as defined by Z above, or is of the formula —N(R)—(CR 2 ) n —X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, and/or oxygen atoms contained in an alkylene chain, and/or may contain keto groups and/or nitrogen or sulfur atoms; in an amount effective to mobilize said progenitor and/or stem cells into the peripheral blood of said subject; whereby said cells are mobilized and myocardium is repaired.