Patent ID: 8044207

Claim:
A process for preparing a 2-halo-6-(piperidin-4-carbonyl)pyridine compound of formula III: where X is bromo or chloro; R 8 is an amino protecting group, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl-C 1 -C 3 alkyl, or a group of formula II: R 6 is hydrogen or C 1 -C 6 alkyl; and n is an integer from 1 to 6 inclusively; comprising 1) reacting a 2,6-dihalopyridine selected from 2,6-dibromopyridine and 2,6-dichloropyridine, with n-butyl lithium to form 2-halo-6-lithium-pyridine, and then 2) reacting the 2-halo-6-lithium-pyridine with a substituted aminocarbonylpiperidine compound of formula IV: wherein R 9 and R 10 are each methyl, or R 9 and R 10 , together with the nitrogen to which they are attached, combine to form azetidinyl, pyrrolidinyl, or piperidinyl.