Patent ID: 8829476

Claim:
An apparatus for treatment planning for delivering a biological dose at a treatment site of a patient, the apparatus comprising: a linear energy transfer (LET) determination module and a relative biological effectiveness (RBE) determination module configured to receive tissue specific parameters that describes a site under treatment and the modules configured to determine a variability of relative biological effectiveness (RBE) along a plurality of hadron beams, wherein RBE is a ratio of a dose of reference radiation to a hadron dose required to achieve an equivalent biological effect; a dose calculation module configured to calculate a hadron biological dose for a plurality of Spread-Out Bragg Peak (SOBP) sections based on the RBE and LET determination, wherein the plurality of SOBP sections include a declining distal edge and at least one other section of the SOBP; and an optimization module configured to provide an optimized map of energies of each of a plurality of beams.