Patent ID: 8034557

Claim:
A method of detecting Hutchinson-Gilford Progeria Syndrome in a subject, comprising determining whether the subject has a mutant LMNA sequence, wherein determining whether the subject has a mutant LMNA sequence comprises reacting at least one LMNA nucleic acid molecule contained in a sample from the subject with a reagent comprising a LMNA-specific oligonucleotide to form a LMNA:oligonucleotide complex, wherein the mutant LMNA sequence encodes: (a) a sequence having at least 95% sequence identity to SEQ ID NO: 2 and comprising the variant E145K; (b) a sequence having at least 95% sequence identity to SEQ ID NO: 2 and comprising the variant R471C; (c) a sequence having at least 95% sequence identity to SEQ ID NO: 2 and comprising the variant R527C; or (d) a sequence having at least 95% sequence identity to SEQ ID NO: 2 and comprising the variant A269V.