Patent ID: RE44768

Claim:
A compound of the structure wherein R 1 and R 2 are each, independently, hydrogen or —CO(CR 3 R 4 ) b (CR 5 R 6 ) d CR 7 R 8 R 9 ; R 3 and R 4 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, trifluoromethyl, or —F; R 5 and R 6 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, —(CR 3 R 4 ) f OR 10 , —CF 3 , —F, or —CO 2 R 11 , or R 5 and R 6 may be taken together to form X or a cycloalkyl ring of 3-8 carbon atoms that is optionally mono-, di-, or tri-substituted with —(CR 3 R 4 ) f OR 10 ; R 7 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2--7 carbon atoms, —(CR 3 R 4 ) f OR 10 , —CF 3 —F, or—CO 2 R 11 ; R 8 and R 9 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, —(CR 3 R 4 ) f OR 10 , —CF 3 , —F, or —CO 2 R 11 , or R 8 and R 9 may be taken together to form X or a cycloalkyl ring of 3-8 carbon atoms that is optionally mono-, di-, or tri-substituted with —(CR 3 R 4 ) f OR 10 ; R 10 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms alkynyl of 2-7 carbon atoms, tri-(alkyl of 1-6 carbon atoms)silyl, tri-(alkyl of 1-6 carbon atoms)silylethyl, triphenylmethyl, benzyl, alkoxymethyl of 2-7 carbon atoms, tri-(alkyl of 1-6 carbon atoms)silylethoxymethyl, chloroethyl, or tetrahydropyranyl; R 11 is hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, or phenylalkyl of 7-10 carbon atoms; X is 5-(2,2-di-(alkyl of 1-6 carbon atoms))[1,3]dioxanyl, 5-(2,2-di-(cycloalkyl of 3-8 carbon atoms))[1,3]dioxanyl, 4-(2,2-di-(alkyl of 1-6 carbon atoms))[1,3]dioxanyl, 4-(2,2-di-(cycloalkyl of 3-8 carbon atoms))[1,3]dioxanyl, 4-(2,2-di-(alkyl of 1-6 carbon atoms))[1,3]dioxalanyl, or 4-(2,2-di-(cycloalkyl of 3-8 carbon atoms))[1,3]dioxalanyl; b=0-6; d=0-6 ; and f=0-6 with the proviso that R 1 and R 2 are both not hydrogen and further provided that either R 1 or R 2 contains at least one —(CR 3 R 4 ) f OR 10 , X, or —(CR 3 R 4 ) f OR 10 substituted cycloalkyl of 3-8 carbon atoms group, or a pharmaceutically acceptable salt thereof.