Patent ID: 7729761

Claim:
A system, comprising: an implantable pulse generator including: a sensor to sense a physiological signal indicative of a predetermined cardiac condition; an event detector, coupled to the sensor, to detect the predetermined cardiac condition from the physiological signal; an implant telemetry module to receive an external command transmitted to the implantable pulse generator; and an implant controller coupled to the event detector and the implant telemetry module, the implant controller including a gene or protein delivery control module configured to produce an electrical signal to control iontophoretic gene or protein delivery in response to the predetermined cardiac condition and the external command; an implantable lead system including one or more leads, the lead system configured to transmit the electrical signal; and an implantable gene or protein delivery device electrically wired to the implantable pulse generator through the implantable lead system, the implantable gene or protein delivery device configured to receive the electrical signal and including a polymer matrix and isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA, or isolated protein, the nucleic acid or protein contained in the polymer matrix and released from the implantable gene or protein delivery device in response to an electric field applied to the polymer matrix, the electric field created by the electrical signal.