Patent ID: 7592349

Claim:
A pharmaceutical composition comprising a therapeutically effective amount of a compound having the structure of Formula (1) or Formula (46): wherein: Ar is a group comprising a moiety selected from an optionally substituted five-membered aromatic heterocycle, an optionally substituted five-membered aromatic carbocycle, an optionally substituted six-membered aromatic heterocycle, and a substituted, optionally further substituted phenyl; Q is a group comprising a non-aromatic tertiary amine or a non-aromatic secondary amine, with the proviso that Q is not —NR a R b or —SO 2 NR a R b ; wherein each of R a and R b is independently H or C 1-6 alkyl optionally substituted by mono- or di-alkyl (C 1-6 ) amino; each R 1 is independently an optionally substituted moiety selected from -L 1 -H or -L 1 -C 1-6 alkyl; wherein L 1 is selected from a bond, —O—, —NH—, —S—, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 —, —C(O)NH(CR″ 2 ) 1-6 C(O)O—, —C(O)NR″NR″C(O)O—, and —S(O)NH—; each R″ is independently H, OH, halogen, C 1-6 alkyl, substituted C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkyl, halo-C 1-6 alkoxy, aryl, haloaryl, or heteroaryl; or any two adjacent R 1 groups together may form an optionally substituted 5 to 8-membered heterocyclic, cycloalkyl, or aryl ring; R 5 is H or C 1-6 alkyl; or a pharmaceutically acceptable salt, or pharmaceutically acceptable N-oxide thereof, in admixture with one or more pharmaceutically acceptable excipients.