Patent ID: 8084470

Claim:
A substituted nicotinamide compound corresponding to formula I wherein n=0, 1 or 2; p=0 or 1; q=0 or 1; R 1 denotes aryl or heteroaryl, each unsubstituted or mono- or poly-substituted; C 1-6 -alkyl, C 3-10 -cycloalkyl or heterocyclyl, each unsubstituted or mono- or poly-substituted; R 2 denotes H or C 1-6 -alkyl, unsubstituted or mono- or poly-substituted; R 3 denotes aryl or heteroaryl, unsubstituted or mono- or poly-substituted; C 1-6 -alkyl or C 3-10 -cycloalkyl, in each case unsubstituted or mono- or poly-substituted; R 4 , R 5 , R 6 and R 7 each independently denote H or C 1-6 -alkyl, unsubstituted or mono- or poly-substituted; and R 8 , R 9 and R 10 each independently denote H, F, Cl, Br, O—C 1-6 -alkyl, CF 3 , OCF 3 , SCF 3 , or C 1-6 -alkyl; with the proviso that when R 3 is 3-trifluoromethylphenyl or 4-trifluoromethyl-2-pyridyl, R 2 , R 4 and R 5 each denote H, and n is 0, then R 1 is not 2-pyridyl or 2-thienyl; and when R 3 is phenyl or methyl, R 2 , R 4 and R 5 each denote H, and n is 0, then R 1 is not 2-thienyl; wherein the substituents on the alkyl, heterocyclyl or cycloalkyl groups replace one or more hydrogen atoms with one or more identical or different substituents selected from the group consisting of F, Cl, Br, I, —CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH) 2 , NO 2 , SH, S—C 1-6 -alkyl, S-benzyl, O—C 1-6 -alkyl, OH, O—C 1-6 -alkyl-OH, ═O, O-benzyl, C(═O)C 1-6 -alkyl, CO 2 H, CO 2 —C 1-6 -alkyl, phenyl, phenoxy, morpholinyl, piperidinyl, pyrrolidinyl and benzyl; and the substituents on the aryl or heteroaryl groups replace one or more hydrogen atoms with one or more identical or different substituents selected from the group consisting of F, Cl, Br, I, CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH 2 , NO 2 , SH, S—C 1-6 -alkyl, OH, O—C 1-6 -alkyl, O—C 1-6 alkyl-OH, C(═O)C 1-6 -alkyl, C(═O)NHC 1-6 -alkyl; o-pyridyl; C(═O)-aryl; C(═O)—N-morpholine; C(═O)-piperidine; (C═O)-pyrrolidine; (C═O)-piperazine; NHSO 2 C 1-6 -alkyl, NHCOC 1-6 -alkyl, CO 2 H, CH 2 SO 2 -phenyl, CO 2 —C 1-6 -alkyl, OCF 3 , SCF 3 , CF 3 , C 1-6 -alkyl, pyrrolidinyl, piperidinyl, morpholinyl, benzyloxy, phenoxy, phenyl, pyridyl, alkylaryl, imidazolyl, pyrazolyl, thienyl and furyl; or a salt thereof with a physiologically acceptable acid.