Patent ID: 7838254

Claim:
A method for identifying a peptide YY (PYY) secretagogue, comprising: (a) contacting in vitro a test compound with a host cell or with a membrane of a host cell comprising a G protein-coupled receptor (GPCR) wherein the GPCR comprises an amino acid sequence selected from the group consisting of: (i) amino acids 1-335 of SEQ ID NO:2; and (ii) an amino acid sequence of a GPCR encoded by the nucleotide sequence set forth in SEQ ID NO:1; (b) determining the ability of the test compound to stimulate functionality of the GPCR; (c) administering a compound which stimulates functionality of the GPCR in step (b) to a vertebrate; and (d) determining whether the compound increases a PYY level in the vertebrate, wherein the ability of the test compound to increase a PYY level in the vertebrate is indicative of the test compound being a PYY secretagogue.