Patent ID: 8143421

Claim:
A compound having the formula or N-oxide, salt, stereoisomeric form, racemic mixture, or ester thereof, wherein R 1 is a bicyclic heterocycle comprising at least 7 atoms, of which at least one is O; L is —O—C(═O)—, —C(═O)—, —CH 2 —O—C(═O)— or —O—CH 2 —C(═O)—; R 2 is —H; R 3 is C 1-4 alkylphenyl; R 4 is C 1-4 alkyl; R 12 is —H; —NH 2 —N(R 5 )(AR 6 ), —C 1-6 alkyl or C 1-6 alkyl —W—R 14 , wherein said C 1-6 alkyl is optionally substituted with hydroxy or amino wherein said amino is optionally mono- or di-substituted with C 1-4 alkyl; A is C 1-6 alkanediyl or —C(═O)—; R 5 is hydrogen; R 6 is C 1-6 alkyloxy, Het 1 , amino; and in case -A- is other than C 1-6 alkanediyl then R 6 may also be C 1-6 alkyl, Het 1 C 1-4 alkyl or aminoC 1-4 alkyl; whereby each of the amino groups may optionally be substituted; W is oxycarbonyloxy; R 14 is Het 1 ; R 13 is H, C 1-4 alkyl, C 1-4 alkylaryl, C 1-4 alkylHet 1 or C 1-4 alkylHet 2 ; Het 1 is a saturated or partially unsaturated monocyclic, bicyclic or tricyclic heterocycle having 5 to 10 ring members, which contains one or more heteroatom ring members selected from nitrogen, oxygen or sulphur and which is optionally substituted on one or more carbon atoms by C 1-6 alkyl, C 1-6 alkyloxy, aminoC 1-6 alkyl, halogen, hydroxy, oxo, amino, mono- or disubstituted amino, aminoalkyl, mono- or disubstituted aminoalkyl, nitro, cyano, haloC 1-6 alkyl, carboxyl, C 1-6 alkoxycarbonyl, C 3-7 cycloalkyl, aminocarbonyl, mono- or disubstituted aminocarbonyl, methylthio, methylsulfonyl, or phenyl; and Het 2 is an aromatic monocyclic, bicyclic or tricyclic heterocycle having 5 to 10 ring members, which contains one or more heteroatom ring members selected from nitrogen, oxygen or sulphur and which is optionally substituted on one or more carbon atoms by C 1-6 alkyl, C 1-6 alkyloxy, aminoC 1-6 alkyl, halogen, hydroxy, amino, mono- or disubstituted amino, nitro, cyano, haloC 1-6 alkyl, carboxyl, C 1-6 alkoxycarbonyl, C 3-7 cycloalkyl, aminocarbonyl, mono- or disubstituted aminocarbonyl, methylthio, methylsulfonyl, or phenyl.