Patent ID: 7625931

Claim:
A compound of Formula 1 or a pharmaceutically acceptable salt thereof, wherein A O; B and D are CH R represents 0 to 2 substituents independently chosen from hydroxy, nitro, cyano, optionally substituted amino, aminocarbonyl, halo, carboxy, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted C 1 -C6 alkyl, optionally substituted C 1 -C 6 alkoxy, sulfanyl, sulfinyl, sulfonyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocycloalkyl; R 1 is optionally substituted heteroaryl; W is chosen from 5-membered heteroaryl wherein the heteroaryl ring contains at least one nitrogen and optionally includes one, two, or three additional heteroatoms, selected from N, O, and S in the ring; Z 1 is —CR 5 R 6 — wherein each R 5 and R 5 is independently chosen from hydrogen, optionally substituted C 1 -C 6 alkyl, and halo; m is chosen from 0, 1, and 2; Z 2 is —CR 7 R 8 — wherein each R 7 and R 8 is independently chosen from hydrogen, optionally substituted C 1 -C 6 alkyl, and halo; n is chosen from 0, 1, and 2; R 2 is optionally substituted phenyl; and R 3 and R 4 are each independently chosen from hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted aryl, and optionally substituted heteroaryl, provided that when n is 0, m is 0, and R is absent, W is not where R 10 is chosen from CF 3 , halo; CN, C 1 -C 8 alkyl, C 1 -C 6 alkenyl; C 3 -C 8 cycloalkyl optionally substituted with a group chosen from hydroxy, cyano, and methoxy, C 1 -C 8 alkoxy; C 1 -C 4 alkyloxyalkyl; C 1 -C 8 alkylthio; C 1 -C 4 alkylthioalkyl; C 1 -C 8 dialkylamino; C 1 -C 4 dialkylaminoalkyl; alkoxycarbonyl optionally substituted with a group chosen from carbocyclyl and heterocyclyl; aryl and heterocyclyl, wherein the aryl and heterocyclyl groups may be optionally substituted with a group chosen from halo, C 1 -C 4 alkyl, C 1 -C 4 alkenyl, CN, dimethylamino, methoxycarbonyl, methoxy, aryl, and heterocyclyl; and when n is 0, m is 0, R is absent, and R 2 is chosen from phenyl and 2-fluoro-5-(trifluoromethyl)phenyl, W is not where R 1 is 4-aminoethieno[2,3-d]pyrimidin-6-yl.