Patent ID: 7893112

Claim:
A method for ameliorating a disease selected from neuropathic pain, Hashimoto's thyroiditis, osteoarthritis, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, psoriasis, pemphigus vulgaris, Graves' disease, myasthenia gravis, systemic lupus erythemotasus, asthma, inflammatory pain or atherosclerosis in an animal mediated by Cathepsin S, which method comprises administering to the animal a pharmaceutical composition comprising a compound of Formula (I): in admixture with one or more suitable excipients, wherein R 1 and R 2 taken together with the carbon atom to which both R 1 and R 2 are attached form cycloalkylene optionally substituted with one or two R b independently selected from alkyl, halo, alkylamino, dialkylamino, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, alkoxycarbonyl, or aryloxycarbonyl; wherein the aromatic or alicyclic ring in the groups attached to cycloalkylene is optionally substituted with one, two, or three substituents independently selected from alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxycarbonyl, alkoxy, hydroxy, haloalkoxy, halo, carboxy, alkoxycarbonyl, amino, monsubstituted amino, disubstituted amino, or acyl; R 3 is hydrogen or alkyl; R 5 is hydrogen or alkyl; R 6 is aryl, optionally substituted by one, two, or three R e independently selected from alkyl, halo, hydroxy, hydroxyalkyl, hydroxyalkoxy, alkoxy, alkoxyalkyl, alkoxyalkyloxy, haloalkyl, haloalkoxy, oxo, cyano, nitro, acyl, cycloalkyl, cycloalkylalkyl, carboxy, alkoxycarbonyl, alkylsulfonyl, aminosulfonyl, or aminoalkyl, and further where the aromatic or alicyclic ring in R e is optionally substituted with one, two or three R f independently selected from alkyl, alkoxy, haloalkyl, haloalkoxy, halo, hydroxy, carboxy, cyano, nitro, aryl or cycloalkyl; R 7 is haloalkyl; R 8 is hydrogen, alkyl, alkoxyalkyl or haloalkyl; R 22 is cycloalkyl, cycloalkylalkyl, aryl or aralkyl, wherein the aromatic or alicyclic ring in R 22 is optionally substituted with one, two, or three R d independently selected from alkyl, haloalkyl, alkoxy, hydroxy, haloalkoxy, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryl, heteroaryl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, amino, monsubstituted amino, disubstituted amino, or acyl; Y is -alkylene-, wherein the alkylene group is optionally substituted with one to six fluoro atoms; and Z is a direct bond or -alkylene-, wherein the alkylene portion is optionally substituted with one to six fluoro atoms.