Patent ID: 8889691

Claim:
A method for the treatment of necrosis and necrosis-associated diseases comprising administering a composition which comprises an indole compound of the following formula (1), pharmaceutically acceptable salt or stereoisomer thereof as an active ingredient together with a pharmaceutically acceptable carrier or diluent to a subject in need thereof: in which n denotes a number of 0 to 3, A represents 5 membered heteroaryl or heterocycle each of which has 1 to 3 hetero atoms selected from N, O and S, R 1 represents R 5 —X—B—X′—, B represents a direct bond, or represents 3˜10 membered heterocycle or heteroaryl each of which has 1 to 4 hetero atoms selected from N, O and S, X and X′ independently of one another represent a direct bond, or are selected from the group consisting of —NR 6 —, —CO—, —CONR 6 —, —CO 2 —, —OC(O)—, —S(O) m —, —O—(CH 2 ) m —, —(CH 2 ) m —O—, —(CH 2 ) m —, —NR 6 CO—, and —NHCO 2 —, wherein m denotes a number of 0 to 3, and R 6 represents hydrogen or C 1 -C 6 -alkyl, R 5 represents hydrogen, hydroxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 4 -C 6 -cycloalkyl or phenyl, or represents 3˜10 membered monocyclic or fused cyclic heterocycle or heteroaryl each of which has 1 to 3 hetero atoms selected from N, O and S, and is optionally substituted by oxo or C 1 -C 6 -alkyl, R 2 represents —(CR 8 R 9 ) p —Y—R 7 , p denotes a number of 0 to 2, R 8 and R 9 independently of one another represent hydrogen or C 1 -C 6 -alkyl, Y represents a direct bond, or is selected from the group consisting of —O—, —NR 6 —, —NR 6 C(O)—, and —S(O) q —, wherein q denotes a number of 0 to 2, R 7 represents hydrogen, halogen, hydroxyl, C 1 -C 6 -alkyl, phenyl, or represents 3˜10 membered heterocycle or heteroaryl each of which has 1 to 3 hetero atoms selected from N, S and O and which optionally contains oxo, R 3 represents hydrogen or C 1 -C 6 -alkyl, R 4 represents C 3 -C 6 -cycloalkyl, where alkyl, alkoxy, phenyl, cycloalkyl, heterocycle and heteroaryl may be optionally substituted, and the substituents are one or more selected from the group consisting of hydroxy, halogen, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfonyl, carboxy-C 1 -C 6 alkyl, and oxo, and wherein necrosis and necrosis-associated diseases are selected from the group consisting of neurodegenerative disease, diabetes, pancreatitis, bacterial/viral sepsis, bacterial infection, viral infection, leukemia, lymphoma, spinal cord injury, muscular dystrophy and anthrax.