Patent ID: 7601847

Claim:
A process comprising: contacting a compound of the formula: wherein: R 2 , R 3 , R 4 , and R 5 , are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, hydroxy, alkoxy of 1-6 carbon atoms, aryloxy of 6-20 carbon atoms, halogen, trifluoromethyl, —CN, —NO 2 , —CHO, or —CO 2 R 11 ; R 6 , R 7 , R 8 , and R 9 , are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, hydroxy, alkoxy of 1-6 carbon atoms, aryloxy of 6-20 carbon atoms, halogen, trifluoromethyl, —CO 2 R 11 , aryl of 6-20 carbon atoms, arylalkyl of 7-26 carbon atoms, or a saturated, unsaturated, or partially unsaturated heterocyclic ring or ring system of 4-14 atoms, containing 1-4 heteroatoms selected from N, O, and S; R 10 is hydrogen, alkyl of 1-6 carbon atoms, —CO 2 R 11 , —CONHR 11 , —P(═O)(OH)OR 11 , —CO(CH 2 ) n CH(NHR 12 )CO 2 R, or a hydroxyl protecting group; R 11 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-20 carbon atoms, or arylalkyl of 7-26 carbon atoms; R 12 hydrogen or —CO 2 R 11 ; and n=0-3; with lithium bis(trimethylsilyl)amide, lithium dicyclohexylamide, or potassium bis(trimethylsilyl)amide in the presence of a dipolar aprotic solvent to produce a first reaction mixture; contacting the first reaction mixture with a compound of the formula R 1 —X, where: R 1 alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkenyl of 4-8 carbon atoms, aryl of 6-20 carbon atoms, arylalkyl of 7-26 carbon atoms, or a saturated, unsaturated, or partially unsaturated heterocyclic ring or ring system of 4-14 atoms, containing 1-4 heteroatoms selected from N, O, and S; and X is a leaving group; to produce a second reaction mixture; mixing the second reaction mixture with at least one alcohol; optionally cooling the second mixture below ambient temperature; precipitating a compound of the formula: isolating the precipitated compound.