Patent ID: 6861043

Claim:
A method for radiotherapy in a human or animal patient which comprises administering a radiotherapeutic effective amount of a nitrogen-containing cascade polymer having complexing ligands which complex at least 16 ions of a radioisotope of an element of atomic numbers 27, 29, 31, 32, 37-39, 43, 49, 62, 64, 70, 75 or 77, which results in radiotherapy on the patient, wherein cascade polymer comprising: a) a complexing ligand of general formula I A-{X—[Y-(Z-(W—K W ) Z ) y ] x } a (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two cascade reproduction units are different and that for the product of the multiplicities, 16 ≦a·x·y·z·w ≦64 holds true, b) at least 16 ions of an element of atomic numbers 27, 29, 32, 37-39, 43, 49, 62, 64, 70, 75 or 77, c) optionally one or more cations of inorganic and/or organic bases, amino acids or amino acid amides, and d) optionally, one or more acylated terminal amino groups.