Patent ID: 8703973

Claim:
A method of treating a digestive disorder requiring prokinetic therapy comprising effective amount of a compound of formula including any stereochemically isomeric form thereof, wherein A represents phenyl, thienyl, furanyl or a 6-membered aromatic heterocycle containing 1 or 2 nitrogen atoms; wherein said phenyl, thienyl, furanyl or 6-membered aromatic heterocycle may optionally be fused with phenyl or a 6-membered aromatic heterocycle containing 1 or 2 nitrogen atoms; Z represents CH 2 or O; R 1 represents halo, hydroxyl, C 1-4 alkyl, C 1-4 alkyloxy, polyhaloC 1-4 alkyl, cyano, nitro, amino, mono or di(C 1-4 alkyl)amino; or in case A represents phenyl then two adjacent R 1 substituents may be taken together to form a radical of formula —O—CH 2 —O— (a-1); or —O—CH 2 —CH 2 —O— (a-2); R 2 represents hydrogen or C 1-4 alkyl; R 3 and R 4 each independently represent hydrogen, C 1-6 alkyl, C 1-4 alkyloxyC 1-6 alkyl or phenylC 1-4 alkyl; or R 3 and R 4 are taken together with the nitrogen to which they are attached to form a radical of formula (b-1) or (b-2) with X 1 representing CH 2 or CHOH; and X 2 representing CH 2 , O or NR 6 ; R 5 represents hydrogen, halo, C 1-4 alkyl, C 1-4 alkyloxy or trifluoromethyl; R 6 represents hydrogen, C 1-4 alkyl, C 1-4 alkylcarbonyl, C 1-4 alkyloxycarbonyl, or phenyloxycarbonyl; n represents an integer of value 0, 1, 2, 3, 4 or 5; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof; provided that the compound is other than or a pharmaceutically acceptable salt thereof.