Patent ID: 8247234

Claim:
A method for synthesizing an isotopically enriched compound, comprising: forming a composition comprised of the formula A-D-E-C(TXZ) wherein A is a support selected from the group consisting of a polymer support, a resin support, a metal support, a nanoparticle support, a magnetic bead support, a silica support, a silicon support, a glass support, a ceramic support, and a core-shell compound support; wherein D comprises aryl having 6-10 ring atoms and an oxygen atom attached to A; wherein E is selected from the group consisting of sulfur, sulfoxide, sulfone, selenium, selenoxide, or selenone; wherein T, X, and Z comprise groups each independently chosen from 1 H, 2 H, a C 1 -C 4 alkyl, fluoro, chloro, bromo, iodo, amino, NHR, NR 2 , and OR; wherein R comprises C 1 -C 4 alkyl, chloro, bromo, amino, a monocyclic aryl, substituted monocyclic aryl, bicyclic aryl, and substituted bicyclic aryl; and wherein at least one of C, T, X, and Z groups comprises a stable isotope, wherein the stable isotope of C is 13 C and wherein the stable isotope of T, X, Z comprises 13 C or 2 H; and subjecting the composition to conditions whereby —C(TXZ) detaches from E and becomes part of an isotopically labeled compound.