Patent ID: 8252321

Claim:
A method for delivering an active substance to a human or animal comprising: providing a transdermal drug delivery device coupled to the human or animal, the delivery device having a source of the active substance, an electronic programmable timing mechanism, a mechanism for causing the active substance to be delivered transdermally in response to the timing mechanism by passive absorption, and an expandable waste reservoir for controlled discontinuance of the delivery of the active substance; and providing timing routines implemented by the timing mechanism, wherein the timing routines are selected to deliver the active substance by passive absorption at a time, rate, sequence and/or cycle that is synchronized with a biological rhythm of the human or animal; and removing the active substance from the skin of the human or animal via the expandable waste reservoir to discontinue delivery of the active substance, wherein the device is maintained in contact with the skin during removal of the active substance via the expandable waste reservoir.