Patent ID: 8097238

Claim:
A cell targeting conjugate comprising the following components that are covalently conjugated via a hydrazone, disulphide or amide bond linker that is degradable within the target cells: a DNA minor groove binding ligand incorporating an effective Auger electron-emitting, gamma-emitting or positron-emitting atom or photoactive moiety; a target cell specific protein or peptide that is capable of internalisation by target cells; wherein the cell targeting conjugate is represented by Formula (I), wherein: X is carbon or nitrogen; Y 1 and Y 2 are selected from C(R′), nitrogen, N(R′), oxygen and sulfur, wherein R′ is hydrogen, optionally substituted alkyl or optionally substituted alkenyl, and wherein Y 1 and Y 2 are not both either C(R′) or nitrogen; ═ is a double bond unless the attached Y 1 or Y 2 is N(R′), oxygen or sulfur in which case it is a single bond; R 1 to R 12 are selected from hydrogen, halogen, hydroxy, amino, optionally substituted alkyl, optionally substituted alkenyl, a moiety including a target cell specific protein or peptide, an Auger electron-emitting moiety, a gamma-emitting moiety, a positron-emitting moiety and a photoactive moiety, and wherein two of R 1 to R 5 may together form optionally substituted cycloalkyl, cycloalkenyl or aryl; wherein at least one of R 1 to R 12 comprises a target cell specific protein or peptide, and wherein at least one other of R 1 to R 12 comprises an Auger electron-emitting moiety, a gamma-emitting moiety, a positron-emitting moiety and/or a photoactive moiety; and salts and/or tautomers thereof.