Patent ID: 7863416

Claim:
A hexapeptide of the formula: Arg-Xaa-Tyr-Arg-Trp-Arg (SEQ ID NO: 17), wherein the hexapeptide binds with the ORL-1 receptor, wherein Xaa is selected from the group consisting of natural amino acids, D-amino acids, non-natural amino acids, and modified natural amino acids, the natural amino acids consisting of Gly, Ala, Val, Leu, Ile, Met, Pro, Phe, Trp, Ser, Thr, Asn, Gln, Cys, Lys, Arg, His, Asp, and Glu, the modified natural amino acids excluding Phe (4-Me), Phe (4-COOH), Phe (4-NO 2 ,), Phe (4-F), Phe (4-CN), Tyr (4-Me), Tyr (3-Cl), and Tyr (BN, 3-Cl), the hexapeptide having an amino terminus and a carboxy terminus, either or both of which may optionally be modified.