Patent ID: 7666647

Claim:
A crystal comprising an unphosphorylated Glycogen Synthase Kinase-3β (GSK-3β) protein complexed to a chemical entity, wherein said GSK-3β protein consists of amino acids 7-420 of SEQ ID NO:1; wherein said crystal is in space group P2 1 2 1 2 1 , and has unit cell dimensions of a=83±2 Å, b=86±2 Å, c=178±2 Å, α=β=γ=90°; and wherein said chemical entity is selected from the group consisting of: (5-Methyl-2H-pyrazol-3-yl)-(2-pyridin-4-yl-quinazolin-4-yl)-amine; 4-(5-Methyl-2-phenylamino-pyrimidin-4-yl)-1H-pyrrole-2-carboxylic acid (2-hydroxy-1-phenyl-ethyl)-amide; and (1H-Indazol-3-yl)-[2-(2-trifluoromethyl-phenyl)-quinazolin-4-yl]-amine).