Patent ID: 8318759

Claim:
A compound of formula I wherein A is —NR′—, —S—, —S(O)— or —S(O) 2 —; R′ is hydrogen or lower alkyl; Ar is a six membered heteroaryl group containing one or two N-atoms; R is a six membered heterocyclic group wherein X 1 is N or CH; and X 2 is —N(R 1 )—, —CH 2 —, —O—, —S—, —S(O)—, or —S(O) 2 —, R 1 is hydrogen, lower alkyl, S(O) 2 -lower alkyl, C(O)-lower alkyl, C(O)-cycloalkyl optionally substituted by lower alkyl; with the proviso that at least one of X 1 or X 2 contains a heteroatom, or is a five or six membered heteroaryl group containing one or two N-atoms, which groups are unsubstituted or are substituted by one or two R 1′ ; wherein R 1′ is lower alkyl or cyano; R 2 is lower alkyl substituted by halogen, cyano or nitro; R 3 is halogen; R 4 is hydrogen or lower alkyl; o is 1 or 2; wherein when o is 2, each R 2 is the same or different; and p is 1 or 2; wherein when p is 2, each R 3 is the same or different; or a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or a tautomeric form thereof.