Patent ID: 8591936

Claim:
A coating for an implantable medical device, the coating comprising a differentially permeable topcoat layer having a non-polar polymer, a drug reservoir layer having a polar polymer, an olimus therapeutic agent, and a non-olimus therapeutic agent, and an optional primer layer; wherein the topcoat layer is deposited over the drug reservoir layer; wherein the drug reservoir layer is deposited over the primer layer if present, or over a surface of the implantable medical device if no primer layer is present; wherein the differentially permeable topcoat layer controls the release of the olimus and non-olimus therapeutic agents; wherein the polymer of the differentially permeable topcoat layer is selected from the group consisting of poly(bl-styrene-bl-ethylene-bl-styrene), poly(bl-styrene-bl-butene-bl-styrene), poly(styrene-b-isobutylene-b-styrene) triblock copolymers, poly(silicone-urethane)s, polyisobutylene and ethylene-α-olefin copolymers, and combinations thereof; wherein the polar polymer in the drug reservoir layer is poly(2-hydroxyethyl methacrylate-co-n-butyl methacrylate); wherein the olimus therapeutic agent in the drug reservoir layer is selected from the group consisting of everolimus, zotarolimus, and combinations thereof; and wherein the non-olimus therapeutic agent in the drug reservoir layer is selected from the group consisting of dexamethasone, dexamethasone acetate, dexamethasone phosphate, dexamethasone valerate, momentasone, clobetasol, and combinations thereof.