Patent ID: 7671092

Claim:
A pharmaceutical composition comprising: a) a pharmaceutically acceptable carrier or diluent; b) a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof; and c) paclitaxel or a paclitaxel analog represented by a structural formula selected from a group consisting of: wherein: R 10 is a lower alkyl group, a substituted lower alkyl group, a phenyl group, a substituted phenyl group, —SR 19 , —NHR 19 or —OR 19; R 11 is a lower alkyl group, a substituted lower alkyl group, an aryl group or a substituted aryl group; R 12 is —H, —OH, lower alkyl, substituted lower alkyl, lower alkoxy, substituted lower alkoxy, —O—C(O)-(lower alkyl), —O—C(O)-(substituted lower alkyl), —O—CH 2 —O-(lower alkyl)-S—CH 2 —O-(lower alkyl); R 13 is —H, —CH 3 , or, taken together with R 14 , —CH 2 —; R 14 is —H, —OH, lower alkoxy, —O—C(O)-(lower alkyl), substituted lower alkoxy, —O—C(O)-(substituted lower alkyl), —O—CH 2 —O—P(O)(OH) 2 , —O—CH 2 —O-(lower alkyl), —O—CH 2 —S-(lower alkyl) or, taken together with R 20 , a double bond; R 15 —H, lower acyl, lower alkyl, substituted lower alkyl, alkoxymethyl, alkthiomethyl, —OC(O)—O(lower alkyl), —OC(O)—O(substituted lower alkyl), —OC(O)—NH(lower alkyl) or —OC(O)—NH(substituted lower alkyl); R 16 is phenyl or substituted phenyl; R 17 is —H, lower acyl, substituted lower acyl, lower alkyl, substituted, lower alkyl, (lower alkoxy)methyl or (lower alkyl)thiomethyl; R 18 —H, —CH 3 or, taken together with R 17 and the carbon atoms to which R 17 and R 18 are bonded, a five or six membered a non-aromatic heterocyclic ring; R 19 is a lower alkyl group, a substituted lower alkyl group, a phenyl group, a substituted phenyl group; R 20 is —H or a halogen; and R 21 is —H, lower alkyl, substituted lower alkyl, lower acyl or substituted lower acyl.