Patent ID: 8357684

Claim:
A chemical entity selected from compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and solvates of compounds of Formula (I) wherein X 4 , X 5 , X 6 , and X 7 are defined as one of the following a) and b): a) one of X 4 , X 5 , X 6 and X 7 is N and the others are CR a ; where each R a is independently H, methyl, chloro, fluoro, or trifluoromethyl; b) each of X 4 and X 7 is N and each of X 5 and X 6 is CH; R 1 and R 2 taken together with the nitrogen to which they are attached form i) a saturated monocyclic heterocycloalkyl ring, optionally fused to a phenyl ring, and unsubstituted or substituted with one or two R d substituents; where each R d substituent is independently C 1-4 alkyl unsubstituted or substituted with —OH; ═O; —(CH 2 ) 0-2 N(CH 3 ) 2 ; —CF 3 ; halo; —CO 2 C 1-4 alkyl; —(CH 2 ) 0-2 CO 2 H; —C(O)NH 2 ; phenyl; benzyl; morpholin-4-yl; pyridyl; pyrimidinyl; 1-piperidyl; phenoxy; 2-oxo-pyrrolidin-1-yl; 4-hydroxy-2-oxo-pyrrolidin-1-yl; —C(O)NR f C 1-4 alkyl; —C(O)NHC(CH 3 ) 2 CH 2 OH; —O-pyridinyl, —O-pyrimidinyl; —S-phenyl; (4-methylphenyl)sulfanyl; —S-pyridinyl; —C(O)—C 1-4 alkyl; —C(O)-saturated monocyclic cycloalkyl; —C(O)—(CH 2 ) 0-1 -2-thiophene-yl; —C(O)-2-furanyl; —C(O)-4-morpholinyl; —C(O)-pyridyl; —C(O)-1-pyrrolidinyl; —C(O)-phenyl optionally substituted with a chloro; —C(O)-1-piperazinyl optionally substituted with C 1-4 alkyl; —(CH 2 ) 0-1 NHC(O)—C 1-4 alkyl; —NHC(O)-saturated monocyclic cycloalkyl; —NHS(O)(O)CH 3 ; —NHC(O)—CH 2 OCH 3 ; —NHC(O)-pyridinyl; or —NHC(O)-2-thiophene-yl, where each phenyl in R d is unsubstituted or substituted with —CF 3 , halo, or methoxy; or ii) one of the following moieties where R e is —C 1-4 alkyl, —C(O)C 1-4 alkyl, —SO 2 CH 3 , —C(O)CH 2 NH 2 , or —C(O)NH 2 ; R f is H or —CH 3 ; and A is —CH 2 —, —CH 2 CH 2 —, or —OCH 2 CH 2 —.