Patent ID: 8877476

Claim:
An isolated 5-Lipoxygenase polypeptide comprising an amino acid sequence, numbered from the N-terminus, as set forth in SEQ ID NO: 1 with one or more of the following modifications selected from the group consisting of: (a) a replacement of amino acids Tryptophan and Phenylalanine at residues 13-14 with Glutamic acid and Histidine, respectively; (b) a replacement of amino acids Proline, Phenylalanine, Tyrosine, Asparagine and Aspartic Acid at residues 40-44 with Glycine-Serine; (c) a replacement of amino acids Tryptophan and Leucine at residues 75-76 with Glycine and Serine, respectively; (d) a replacement of amino acid Cysteine at residue 240 with Alanine; (e) a replacement of amino acid Cysteine at residue 561 with Alanine; and (f) a replacement of amino acids Lysine, Lysine and Lysine at residues 653-655 with Glutamic acid, Asparagine, and a non-positively charged amino acid, respectively.