Patent ID: 7651997

Claim:
A pharmaceutical composition comprising a tamandarin analog having the structure wherein: i) R 1 is selected from the group consisting of —(N-methyl)leucine-deoxo-proline, —(N-methyl)leucine-deoxo-proline-lactate, —(N-methyl)leucine-deoxo-proline-pyruvate, —(N-methyl)leucine-deoxo-proline-lactate-(a first fluorophore), —(N-methyl)leucine-deoxo-proline-lactate-glutamine-pyroglutamate, —(N-methyl)leucine-deoxo-proline-lactate-glutamine-cyclopentanoate, —(N-methyl)leucine-deoxo-proline-alanine-leucine-pyroglutamate, —(N-methyl)leucine-deoxo-proline-(N-methyl-alanine)-leucine-pyroglutamate, —(N-methyl)leucine-dehydro-proline, —(N-methyl)leucine-dehydro-proline-lactate, —(N-methyl)leucine-dehydro-proline-pyruvate, —(N-methyl)leucine-dehydro-proline-lactate-(a first fluorophore), —(N-methyl)leucine-dehydro-proline-lactate-glutamine-pyroglutamate, —(N-methyl)leucine-dehydro-proline-lactate-glutamine-cyclopentanoate, —(N-methyl)leucine-dehydro-proline-alanine-leucine-pyroglutamate and —(N-methyl)leucine-dehydro-proline-(N-methyl-alanine)-leucine-pyroglutamate ii) R 2 and R 3 are one of (a) R 2 is selected from the group consisting of an isoleucine side chain, a valine side chain, an alanine side chain, a norleucine side chain, a norvaline side chain, a leucine side chain, a histidine side chain, a tryptophan side chain, an arginine side chain, a lysine side chain, a second fluorophore, and a substituent having the structure and R 3 is selected from the group consisting of —CH 3 and —H; or (b) R 2 and R 3 form the structure iii) each of R 5 , R 6 , R 7 , R 8 , and R 9 , when present, is independently selected from the group consisting of —H, —OH, —OCH 3 , —CO(C 6 H 5 ), —Br, —I, —F, —Cl, —CH 3 , and —C 2 H 5 ; iv) R 4 is selected from the group consisting of an isoleucine side chain and a valine side chain; v) X is selected from the group consisting of —O— and —(NH)—; vi) Y is selected from the group consisting of —H and a hydroxyl protecting group; and vii) R 10 is selected from the group consisting of a leucine side chain and a lysine side chain; and a pharmaceutically acceptable carrier.