Patent ID: 7713939

Claim:
A method to treat cancer comprising administering an effective amount of a compound of the formula wherein R 1 is (CH 2 ) n —X—Y, where n is 0 to 4; X is O or S or NH, and Y is —CH 2 OC(O)(C 1 -C 4 )alkyl; (C 1 -C 8 )alkyl optionally substituted with 1-2 OH or 1-2 halo; a monosaccharide; —CH 2 C(O)—O—(CH 2 ) 2 —O—C(O)CH 2 SH; —(CH 2 ) 2 —O—(CH 2 ) 2 W where W is halo; —(C 1 -C 8 )alkyl-O—(C 1 -C 8 )alkyl; (C 6 -C 10 )aryl; (C 6 -C 10 )aryl(C 1 -C 4 )alkyl or —C(O)O(C 6 -C 10 )aryl wherein the aryl group is optionally substituted with 1-2 OH, halo, (C 1 -C 4 )alkyl, or O(C 1 -C 4 )alkyl; —CH 2 CO 2 (C 1 -C 4 )alkyl; —CH 2 CO 2 H; Si((C 1 -C 4 )alkyl) 3 or an amino acid residue; R 3 is H or (C 1 -C 4 )alkyl; R 4 is SCH 2 CO 2 (C 1 -C 4 )alkyl, —S—(C 6 -C 10 )aryl optionally substituted with halo, OH or (C 1 -C 4 )alkyl, or H; R 5 is H, OH or absent; R 6 is (C 1 -C 4 )alkyl or H; R 7 is OH or —O(Si((C 1 -C 4 )alkyl) 3 ; or R 6 and R 7 together are ethylenedioxy; R 8 is (C 1 -C 4 )alkyl optionally comprising OH or halo; the bond represented by ---- is present or absent; or a pharmaceutically acceptable salt thereof to a subject in need thereof, wherein the cancer is lung cancer or hematopoietic cell cancer.