Patent ID: 7838680

Claim:
A process for preparing triazole derivatives of formula (I) in which X is nitrogen; Het is aryl or heteroaryl; each of which may be substituted by 1 to 4 groups J selected from the group consisting of: halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halo C 1 -C 6 alkoxy, —C(O)R 1 , nitro, hydroxy, —NR 2 R 3 , and cyano; R 1 is C 1 -C 4 alkyl, —OR 3 or —NR 3 R 4 ; R 2 is hydrogen or C 1 -C 6 alkyl; R 3 is hydrogen or C 1 -C 6 alkyl; R is methyl; according to the following Scheme 1: in which step a is (i) a reaction in basic conditions of a compound (IIA) with, (ii) 4-methyl-3 -thiosemicarbazide, (iii) followed by a treatment with an inorganic base and n-propane phosphonic cyclic anhydride, and (iv) finally pH adjustement with an inorganic acid to give a compound of formula (I).