Patent ID: 8299252

Claim:
A compound represented by Formula (1) of: a pharmaceutically acceptable salt thereof, wherein Ar is an arylene linking group selected from the following formulae: wherein * represents a binding site to the nitrogen atom, and ** represents a binding site to T; T is —(O) n —R; R is selected from the group consisting of a C 1 -C 6 alkyl group, a C 3 -C 8 cycloalkyl group, a C 2 -C 6 alkenyl group, a C 2 -C 6 alkynyl group, a phenyl group, a tetrahydrofuranyl group, a tetrahydrothiopyranyl group, a 1-oxotetrahydrothiopyranyl group, a 1,1-dioxotetrahydrothiopyranyl group, and a tetrahydropyranyl group, wherein each of these groups may be optionally substituted by one to three substituents independently selected from the group consisting of a hydroxyl group, an oxo group, a halogen atom, and a C 1 -C 6 alkoxy group; n is 0 or 1; X is O, S(O) m , CH 2 , C═O, or NR 1 , wherein m is an integer of 0 to 2, and R 1 is H or a C 1 -C 3 alkyl group; R 2 , R 3 and R 4 are independently selected from the group consisting of a hydrogen atom and C 1 -C 3 alkyl, where the alkyl group may be optionally substituted by one to three substituents independently selected from the group consisting of a hydroxyl group, an oxo group, a C 1 -C 3 alkoxy group, and a C 1 -C 3 alkoxy-C 1 -C 3 alkoxy group; or R 2 and R 3 together with the urea structure containing the nitrogen atoms to which they are bonded may form a 5- or 6-membered heterocycle, which may be optionally substituted by one to three substituents independently selected from the group consisting of an oxo group and a hydroxyl group; and Y is CH or N.