Patent ID: 8546349

Claim:
A method for decreasing expression of VEGFA in vivo, comprising administering an siRNA to a subject, wherein the siRNA comprises: a sense strand; and an antisense strand, wherein each of said sense strand and said antisense strand is 19-36 nucleotides in length and the antisense strand comprises SEQ ID NO: 54 and wherein: (a) within the sense strand, nucleotides at positions 1 and 2, all C nucleotides and all U nucleotides have 2′—O—methyl modifications, and all other nucleotides of the sense strand have 2′OH groups; and (b) within the antisense strand, all C nucleotides and all U nucleotides have 2′Fluoro modifications and all other nucleotides of the antisense strand have 2′OH groups, and the nucleotide at position 1 of the antisense strand is 5′phosphorylated.