Patent ID: 6953806

Claim:
A compound of formula (I): wherein U is O or a lone pair, V is a single bond, or —CH 2 —, W is SO 2 , m and n independently from each other are from 0 to 7 and m+n is from 0 to 7, with the proviso that m is not 0 if V is O or S, A 1 is hydrogen, lower-alkyl, hydroxy-lower-alkyl, or lower-alkenyl, A 2 is 3 to 6 carbon atoms cycloalkyl, 3 or 6 carbon atoms cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkynyl, heteroaryl, which is an aromatic 5- to 6-membered ring comprising 1 to 3 hetero atom selected from nitrogen, oxygen and sulphur, substituted heteroaryl, or lower-alkyl optionally substutited by R 2 , or A 1 and A 2 are bonded to each other to form a ring with the N atom to which they are attached, and —A 1 —A 2 — is lower-alkylene or lower-alkenylene, optionally substituted by R 2 , in which one —CH 2 — group of —A 1 —A 2 — can optionally be replaced by NR 3 , S, or O, or —A 1 —A 2 — is —CH═N—CH═CH— which can optionally be substituted by lower-alkyl, A 3 and A 4 independently from each other are hydrogen or lower-alkyl, or A 3 and A 4 are bonded to each other to form a ring together with the carbon atom to which they are attached and —A 3 —A 4 — is —(CH 2 ) 2-5 —, A 5 , A 6 , A 7 and A 8 independently from each other are hydrogen or lower-alkyl, A 9 is hydrogen, lower-alkyl, lower-alkenyl, or aryl-lower-alkyl, A 10 is aryl or substituted aryl, p is 0 or 1, R 2 is hydroxy, hydroxy-lower-alkyl, lower-alkoxy, lower-alkoxycarbonyl, N(R 4 ,R 5 ), thio-lower-alkoxy or halogen, R 3 , R 4 and R 5 independently from each other are hydrogen or lower-alkyl, substituted aryl and substituted heteroaryl are aryl and heteroaryl, respectively, substituted by 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkynyl, dioxo-lower-alkylene, halogen, hydroxy, CN, CF 3 , NH 2 , N(H, lower-alkyl), N(lower-alkyl) 2 , aminocarbonyl, carboxy, NO 2 , lower-alkoxy, thio-lower-alkoxy, lower-alkylcarbonyl, lower-alkylcarbonyloxy, lower-alkoxycarbonyl, phenyl, and phenyloxy, or a pharmaceutically acceptable salts thereof, with the proviso that the compound of formula (I) is not trans-naphthalene-1-sulfonic acid methyl-(4-methylaminomethyl-cyclohexylmethyl)-amide.