Patent ID: 8470297

Claim:
A method for treating a Ewing's sarcoma tumor, in a subject, comprising evaluating glucose metabolism of the tumor after the subject has received a first dose of IGF1R inhibitor, but before a second dose of the inhibitor; or within 14 days of a first dose of IGF1R inhibitor but before a second dose of said inhibitor; wherein treatment with the IGF1R inhibitor is discontinued if glucose metabolism does not significantly decrease or remain constant after said first dose; and continuing treatment with the IGF1R inhibitor if glucose metabolism does significantly decrease or remain constant after said first dose; wherein the IGF1R inhibitor is an isolated antibody or antigen-binding fragment thereof comprising a light chain immunoglobulin comprising CDR1, CDR2 and CDR3 of an immunoglobulin light chain whose amino acid sequence is set forth in SEQ ID NO: 24; and, a heavy chain immunoglobulin comprising CDR1, CDR2 and CDR3 of an immunoglobulin heavy chain whose amino acid sequence is set forth in SEQ ID NO: 18.