Patent ID: 7173024

Claim:
A compound of the formula (I) wherein in the formula, the symbol Q is: a straight or branched alkylene chain having 1 to 6 carbon atoms optionally substituted with 1 to 2 substituent(s) each independently being hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, halogen, carboxyl or lower acyl, a phenylene group optionally substituted with 1 to 2 substituent(s) each independently being lower alkyl, hydroxy, lower alkoxy, amino, lower alkyl amino, halogen, carboxyl or lower acyl, or a cycloalkylene group with 5 to 7 carbon atoms optionally substituted with 1 to 2 substituent(s) each independently being lower alkyl, hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, halogen, carboxyl or lower acyl; the symbol A is: a straight or branched alkyl chain having 1 to 3 carbon atoms optionally substituted with COOR 1 , COR 1 , COCH 2 OR 3 , cyano, hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, or halogen, wherein R 1 is H or lower alkyl and R 3 is H, a 5 to 7 membered saturated or unsaturated carbocyclic ring optionally substituted with lower alkyl, COOR 1 , COR 1 , COCH 2 OR 3 , cyano, hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, or halogen, wherein R 1 is H or lower alkyl and R 3 is H, or a 5 to 7 membered saturated heterocyclic ring optionally substituted with lower alkyl, COOR 1 , COR 1 , COCH 2 OR 3 , cyano, hydroxy, oxo, lower alkoxy, amino, lower alkyl amino, or halogen, wherein R 1 is H or lower alkyl and R 3 is H; the symbol G is -aaâ€²-E, wherein E is: a straight or branched alkyl chain having 1 to 5 carbon atoms optionally substituted with COOR 1 , COR 1 , COCH 2 OR 3 , cyano, hydroxy, oxo, lower alkoxy, aryloxy, aryl lower alkoxy, amino, lower alkyl amino, aryl amino, aryl lower alkyl amino, or halogen, wherein R 1 is H or lower alkyl and R 3 is H, a 5 to 7 membered, saturated or unsaturated, carbocyclic ring optionally substituted with lower alkyl, COOR 1 , COR 1 , COCH 2 OR 3 , cyano, hydroxy, oxo, lower alkoxy, aryloxy, aryl lower alkoxy, amino, lower alkyl amino, aryl amino, aryl lower alkyl amino, or halogen, wherein R 1 or lower alkyl and R 3 is H; or a 5 to 7 membered, saturated or unsaturated, heterocyclic ring optionally substituted with lower alkyl, COOR 1 , COR 1 , COCH 2 OR 3 , cyano, hydroxy, oxo, lower alkoxy, aryloxy, aryl lower alkoxy, amino, lower alkyl amino, aryl amino, aryl lower alkyl amino, or halogen, wherein R 1 or lower alkyl and R 3 is H; the symbols aa and aaâ€² mean a residue of an Î±-amino acid, whereby aa can be the same or different from aaâ€², wherein at least one of aa and aaâ€² is L-prolyl, and the other of aa and aaâ€² is L-prolyl, L-alanyl, L-methionyl, L-phenylalanyl, or L-thioprolyl, or a pharmaceutically acceptable salt thereof.