Patent ID: 7901574

Claim:
A chromatography column, having a longitudinal axis, for use in a liquid chromatography process, said column comprising: a chromatography tube with an opening at both ends; a piston tube with an opening at both ends and an outer diameter smaller than an inner diameter of said chromatography tube; said piston tube having at least one porous layer obstructing a transverse cross section of its interior; at least one chromatography clamp; said chromatography clamp being selectively movable between open and closed positions, and configured to extend substantially 360 degrees about the periphery of said chromatography tube when closed, with no single component of said chromatography clamp extending substantially 360 degrees of said chromatography tube; said chromatography clamp configured to releasably maintain said chromatography tube and piston tube in fluid communication with one another; an interior surface of said chromatography clamp being threaded, sized and shaped to threadably engage an outer surface of said piston tube; said chromatography clamp configured to rotate relative to a periphery of said chromatography tube, while said piston tube is held rotationally static relative to said chromatography tube, wherein rotation of said chromatography clamp is configured to move said piston tube axially within said chromatography tube.