Patent ID: 7923239

Claim:
A detection system comprising: (a) a biosensor, wherein the biosensor comprises: (i) a one-dimensional grating surface structure comprised of a material having a low refractive index; (2) a high refractive index material layer that is applied on top of the low refractive index one-dimensional grating layer; and (3) one or more specific binding substances immobilized on a surface of the high refractive index layer opposite of the one-dimensional grating surface structure comprised of a material having a low refractive index; wherein the one or more specific binding substances do not comprise detection labels; wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum; and wherein the cross-sectional period of the one-dimensional grating is less than the wavelength of the resonant grating effect; (b) a light source that directs light to the biosensor; and (c) a detector that detects light reflected or transmitted from the biosensor.