Patent ID: 8022099

Claim:
A compound of formula I wherein Ar is aryl; R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cyano, amino, mono or di-lower alkyl amino, C(O)-lower alkyl, aryl or heteroaryl; R 2 is hydrogen or halogen; R 3 is —(CH 2 ) p -heterocyclyl optionally substituted by one or two substituents R 4 ; or is lower alkyl, lower alkoxy, —(CH 2 ) p —O-lower alkyl, —(CH 2 ) p —CN, —O—(CH 2 ) p —CN, —(CH 2 ) p -heteroaryl, —(CH 2 ) p —C(O)-heteroaryl, —O—(CH 2 ) p -heterocyclyl, —(CH 2 ) p -aryl optionally substituted by lower alkoxy or halogen, —(CH 2 ) p —O-aryl optionally substituted by lower alkyl, —(CH 2 ) p —NR′-heterocyclyl optionally substituted by lower alkyl, —CH 2 ) p —NR′R″, —CH 2 ) p —NR′—CH 2 ) p′ —NR′R″, —CH 2 ) p —NR′—CH 2 ) p′ —CN, —CH 2 ) p —C(O)—NR′R″ or —O—(CH 2 ) p —NR′R″; R 4 is hydroxy, lower alkyl, —(CH 2 ) p —OH, —(CH 2 ) p —NR′R″, —NR′—C(O)-lower alkyl, —(CH 2 ) p —CN, —S(O) 2 -lower alkyl, —NR′—S(O) 2 -lower alkyl, —S(O) 2 —NR′R″, —C(O)-lower alkyl, —C(O)-lower cycloalkyl wherein the cycloalkyl is optionally substituted by lower alkyl, —C(O)—NR′R″, heterocyclyl which is optionally substituted by ═O, heteroaryl which is optionally substituted by alkoxy or cyano, aryl which is optionally substituted by alkoxy or cyano, or is 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; R′ and R″ are each independently hydrogen, lower alkyl or —(CH 2 ) p —OH, n is 1 or 2; wherein when n is 2, each R 1 is the same or different; o is 1 or 2; wherein when o is 2, each R 2 is the same or different; p and p′ are each independently 0, 1, 2, 3 or 4; or a pharmaceutically active salt, racemic mixture, enantiomer, optical isomer or tautomeric form thereof.