Patent ID: 7105507

Claim:
A compound of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: R 1 represents fluoroC 1-6 alkyl or halogen; R 2 represents hydrogen or halogen; R 3 represents hydrogen, halogen, or fluoroC 1-6 alkyl; R 4 is hydrogen, halogen or CF 3 ; R 5 is hydrogen, halogen or CF 3 ; R 6 represents hydrogen, hydroxy or a C 1-4 alkyl group optionally substituted by a hydroxy group; R 7 represents —(CH 2 ) n NR 8 R 9 , where R 8 and R 9 , together with the nitrogen atom to which they are attached, represent a heteroaliphatic ring selected from the group consisting of: R 10 and R 11 each independently represent hydrogen, halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, hydroxyC 1-6 alkyl, fluoroC 1-6 alkyl, C 1-6 alkoxy, (CH 2 ) q C 3-7 cycloalkyl, (CH 2 ) q aryl, (C 2-6 alkenyl)aryl, (C 2-6 alkynyl)aryl, (CH 2 ) q heterocyclyl, (CH 2 ) q NR a R b , O(CH 2 ) q C 3-7 cycloalkyl, O(CH 2 ) q aryl, O(CH 2 ) q heterocyclyl, O(CH 2 ) p NR a R b , OC(O)C 1-6 alkyl, C(O)C 1-6 alkyl, C(O)(CH 2 ) q aryl, C(O)(CH 2 ) q heterocyclyl, C(O)(CH 2 ) q NR a R b , CO 2 H, CO 2 C 1-6 alkyl, CO 2 (CH 2 ) q C 3-7 cycloalkyl, CO 2 (CH 2 ) q aryl, CO 2 (CH 2 ) q heterocyclyl or CO 2 (CH 2 ) p NR a R b , where R a and R b each independently represent hydrogen, C 1-4 alkyl, C 3-5 cycloalkyl, fluoroC 1-4 alkyl or CH 2 CO 2 C 1-4 alkyl; R 12 represents hydrogen, C 1-6 alkyl, (CH 2 ) q C 3-7 cycloalkyl, (CH 2 ) q aryl, (CH 2 ) q heterocyclyl, CHO, C(O)C 1-6 alkyl, C(O)(CH 2 ) q C 3-7 cycloalkyl, C(O)(CH 2 ) q aryl, C(O)(CH 2 ) q heterocyclyl, CO 2 C 1-6 alkyl, CO 2 (CH 2 ) q C 3-7 cycloalkyl, CO 2 (CH 2 ) q aryl, CO 2 (CH 2 ) q heterocyclyl or CO 2 (CH 2 ) p NR a R b ; R 13 represents hydrogen, C 1-6 alkyl or C(O)C 1-6 alkyl; R 14 and R 15 each independently represent hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkenyl, hydroxyC 1-6 alkyl, C 1-4 alkoxyC 1-4 alkyl, (CH 2 ) p NR a R b , CHO, C(O)C 1-6 alkyl or CO 2 C 1-6 alkyl; or, R 14 and R 15 together represent —CH 2 CH 2 —; R 18 and R 19 each independently represent hydrogen, halogen, hydroxy, C 1-6 alkyl or oxo (═O); R 20 represents hydrogen, halogen, hydroxy, C 1-4 alkyl, hydroxyC 1-4 alkyl or fluoroC 1-4 alkyl; R 21a represents hydrogen, halogen or hydroxy and R 21b represents hydrogen; or R 21a and R 21b both represent fluorine or together represent oxo (═O); n is zero, 1 or 2; m is 1 or 2; p is 1, 2, 3 or 4; q is zero, 1, 2, 3 or 4; and s is 1, 2 or 3; or a pharmaceutically acceptable salt or an N-oxide thereof.