Patent ID: 7635713

Claim:
A compound of the following Formula III, or a pharmaceutically acceptable salt thereof: wherein each R′ is independently hydrogen; optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted heteroalkyl; optionally substituted heteroalkenyl; optionally substituted heteroalkynyl; optionally substituted carbocyclic aryl; optionally substituted aralkyl; optionally substituted heteroalicyclic, optionally substituted heteroaryl; optionally substituted heteroarylalkyl; or optionally substituted heteroalicyclicalkyl; G is oxo (═O), hydroxyl, or optionally substituted alkoxy; p is an integer of from zero to 4; Y is (CR 2 R 3 ) q which may include 0 or 1 C═C double bonds, q is from 1 to 6 and R 2 and R 3 are each independently selected at each occurrence from the group consisting of hydrogen, optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; hydroxy, halogen; and optionally substituted alkoxy; and U and U′ are each independently selected from hydrogen, hydroxy or optionally substituted alkyl; A and B taken in combination form an optionally substituted 1,2-vinylene group or an ethynyl group; V is (CR 2 R 3 ) m , optionally substituted divalent aryl, or optionally substituted divalent heteroaryl; L is C(O)Z; Z is hydroxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, amino, NR 4 R 5 , optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, or optionally substituted heteroarylalkyl; n is an integer selected from 0-3; m is an integer selected from 1-6; R 4 and R 5 are independently selected at each occurrence from the group consisting of hydrogen optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, and optionally substituted heteroarylalkyl, or R 4 and R 5 taken in combination is an optionally substituted heterocycloalkyl.