Patent ID: 7390923

Claim:
A compound of formula (I) wherein R1 is (C 1 -C 7 )alkyl, hydroxy(C 1 -C 7 )alkyl or —(CH 2 ) n —CHO, wherein n is 0-6; R2 is nitro, cyano or halogen; R3 is hydrogen, (C 1 -C 7 )alkyl or halo(C 1 -C 7 )alkyl; R4 is hydrogen, (C 1 -C 7 )alkyl, COR 10 or SO 2 R 13 ; X is O or NH; A is a group selected from: wherein R 5 , R 6 , R 7 , R 8 and R 9 are independently selected from hydrogen, halogen, nitro, cyano, (C 1 -C 7 )alkyl, halo(C 1 -C 7 )alkyl, cyano(C 1 -C 7 )alkyl, amino, mono- or di(C 1 -C 7 )alkylamino, amino(C 1 -C 7 )alkyl, hydroxy(C 1 -C 7 )alkyl, (C 1 -C 7 )alkoxy(C 1 -C 7 )alkyl, —NHCOR 10 , —N(COR 10 ) 2 , —COR 11 , —OR 12 , —OSO 2 R 13 , —SO 2 R 14 , —NHSO 2 R 13 , SR 15 and an imide ring; or R 5 and R 6 , R 6 and R 7 , R 7 and R 8 , or R 8 and R 9 form, together with any of the ring atom(s) to which they are attached, a condensed 5 to 7 membered aliphatic or aromatic carbocyclic ring or a condensed 5 to 7 membered heterocyclic ring containing 1 to 3 heteroatom(s) selected from N, O and S; R 10 and R 11 are independently selected from (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, halo(C 1 -C 7 )alkyl, amino(C 1 -C 7 )alkyl, mono- or di(C 1 -C 7 )alkylamino(C 1 -C 7 )alkyl, (C 6 -C 10 )aryl, —N(R 16 ) 2 and —OR 17 ; R 12 and R 15 are independently selected from hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, halo(C 1 -C 7 )alkyl, amino(C 1 -C 7 )alkyl, mono- or di(C 1 -C 7 )alkylamino(C 1 -C 7 )alkyl, (C 6 -C 10 )aryl, and —COR 18 ; R 13 and R 14 are independently selected from (C 1 -C 7 )alkyl or (C 2 -C 7 )alkenyl, halo(C 1 -C 7 )alkyl and (C 6 -C 10 )aryl; R 16 and R 17 are independently selected from hydrogen, (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, halo(C 1 -C 7 )alkyl, amino(C 1 -C 7 )alkyl and (C 6 -C 10 )aryl; R 18 is (C 1 -C 7 )alkyl, (C 2 -C 7 )alkenyl, halo(C 1 -C 7 )alkyl or (C 6 -C 10 )aryl; R 19 and R 20 are independently selected from hydrogen, halogen, (C 1 -C 7 )alkyl and (C 2 -C 7 )alkenyl; and wherein each aryl or ring residue defined above may be substituted; or a pharmaceutically acceptable salt or ester thereof.