Patent ID: 7781474

Claim:
A compound of the formula (I): or a pharmaceutically acceptable salt or ester thereof wherein: R 1 and R 2 are each independently substituted or unsubstituted groups selected from H, halogen, CN, CF 3 , C 1-8 alkoxyl, C 1-8 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, C 7-10 arylalkyl, or C 6-12 heteroarylalkyl, or R 1 and R 2 taken together form a substituted or unsubstituted C 3-7 cycloalkyl, aryl or heteroaryl ring; R 3 and R 4 are each independently substituted or unsubstituted moieties selected from the group consisting of H, C 1-8 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, C 7-10 arylalkyl, and C 6-12 heteroarylalkyl, or R 3 and R 4 taken together form a substituted or unsubstituted C 3-7 cycloalkyl ring; R 5 is a substituted or unsubstituted moiety selected from the group consisting of H, C 1-8 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, aryl, C 7-10 arylalkyl, heteroaryl, C 6-12 heteroarylalkyl, —C 1-8 alkyl-NHC(O)OR 1a , —C 3-7 cycloalkyl-NHC(O)OR 1a , —C 4-10 cycloalkyl-alkyl-NHC(O)OR 1a , -aryl-NHC(O)OR 1a , —C 7-10 arylalkyl-NHC(O)OR 1a , -heteroaryl-NHC(O)OR 1a , and —C 6-12 heteroarylalkyl-NHC(O)OR 1a ; Y has a formula selected from the group consisting of —C(O)NHS(O) 2 R 1a , —C(O)NHS(O) 2 NR 1a R 1b , —C(O)C(O)NR 1a R 1b , C(O)C(O)OH, —C(O)NHR 1a , —C(O)R 1a , —C(O)OR 1a , —C(O)NHC(O)R 1a and —C(O)OH; wherein R 1a and R 1b are each independently substituted or unsubstituted groups selected from the group consisting of H, C 1-6 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, aryl, C 7-10 arylalkyl, heteroaryl, and C 6-12 heteroarylalkyl, or NR 1a R 1b forms a substituted or unsubstituted three- to six-membered alkyl cyclic secondary amine, or NR 1a R 1b is a heteroaryl or heterocyclic ring.