Patent ID: 7232829

Claim:
A compound of formula (I): wherein R 1 is (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 3 –C 7 )cycloalkyl, (C 5 –C 7 )cycloalkenyl, (C 3 –C 6 )cycloalkyl(C 1 –C 6 )alkyl, (C 5 –C 7 )cycloalkenyl(C 1 –C 6 )alkyl, aryl, heteroaryl, aryl(C 1 –C 6 )alkyl, or heteroaryl(C 1 –C 6 )alkyl; R 2 is H, OH, (C 1 –C 6 )alkoxy, (C 1 –C 6 )alkanoyloxy, NR a R b or SR c ; R 3 is H, aryl(C 1 –C 6 )alkyl, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkanoyl, or (C 1 –C 6 )alkylC(═S); R 4 is ═O, ═S, or ═NR d ; R d is H, CN, CONH 2 , COCF 3 , (C 1 –C 6 )alkanoyl, (C 1 –C 6 )alkyl, or (CH 2 ) p NR e R f ; or R d together with R 6 is —(CH 2 ) q — and forms a ring; p is 1, 2, 3, or 4; R 5 is NR m ; R 6 is H, (C 1 –C 6 )alkyl, (C 3 –C 7 )cycloalkyl, aryl, heteroaryl, aryl(C 1 –C 6 )alkyl, heteroaryl(C 1 –C 6 )alkyl, NR g R h (C 1 –C 6 )alkyl, or C(═NR j )NHR k ; or when R 4 is ═NR d , R 6 together with R d is —(CH 2 ) q — and forms a ring; q is 2 or 3; X is O, S, or NY; Y is H, (C 1 –C 6 )alkyl, or aryl(C 1 –C 6 )alkyl; n is 0, 1, 2, 3, or 4; R a –R c and R e –R f are each independently H, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkanoyl, or —C(═S)(C 1 –C 6 )alkyl; R g and R h are each independently H, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkanoyl, —C(═NH)NR a R b , or —C(═S)(C 1 –C 6 )alkyl, or R g and R h together with the nitrogen to which they are attached are pyrrolidino, piperidino or morpholino; R j and R k are each independently H, (C 1 –C 6 )alkyl, (C 2 –C 6 )alkenyl, (C 2 –C 6 )alkynyl, (C 3 –C 7 )cycloalkyl, (C 3 –C 7 )cycloalkyl(C 1 –C 6 )alkyl, (C 5 –C 7 )cycloalkenylalkyl, aryl, heteroaryl, aryl(C 1 –C 6 )alkyl, or heteroaryl(C 1 –C 6 )alkyl; and R m is hydrogen or (C 1 –C 6 )alkyl; or a pharmaceutically acceptable salt thereof.