Patent ID: 8710243

Claim:
A compound of formula(I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein R 1 is selected from the group consisting of halogen, cyano, nitro, OR A , N(R B ) 2 , —C(O)C 1-4 alkyl, —SO 2 C 1-4 alkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl, trihaloC 1-6 alkyl, haloC 2-6 alkenyl, dihaloC 2-6 alkenyl, trihaloC 2-6 alkenyl, cyanoC 1-6 alkyl, C 1-4 alkoxyC 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, phenyl, benzyl, and 5-10 membered heterocyclyl, wherein said phenyl, benzyl or heterocyclyl group can be either unsubstituted or substituted with from 1 to 3 substituents, each substituent being independently selected from the group consisting of OR A , halogen, cyano, nitro, —C(O)C 1-4 alkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl and trihaloC 1-6 alkyl; R 2 is selected from the group consisting of cyano, nitro, N(OH) 2 , —CHO, —CH═N—OH, —C(O)C 1-4 alkyl optionally substituted with from 1 to 3 halogens, —SO 2 C 1-4 alkyl, —C(O)NH—OH, —C(NH 2 )═N—OH, —C(CO 2 H)═N—OH, —C(NH 2 )═NH, —C(NH 2 )═N—NH 2 , —NH—C(NH 2 )═NH, —NH—C(O) NH 2 , —N═C(—NH—CH 2 CH 2 —NH—), —S—CN, —S—C(NH 2 )═NH, —S—C(NH 2 )═N—OH, —CO 2 H, —CH(OH) CO 2 H, —C(O)N(R C ) 2 , —SO 2 C 1-6 alkyl, SO 2 N(R C ) 2 , —C(O)—C(O)—NH 2 , —CH 2 NH—CONH 2 , —SO 2 OR C , —C(O)CO 2 H, —CH 2 SO 3 H and 5-10 membered heterocyclyl wherein said heterocyclyl group can be either unsubstituted or substituted with from 1 to 3 substituents each substituent being independently selected from the group consisting of OR A , halogen, cyano, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl and trihaloC 1-6 alkyl; each of R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is independently selected from the group consisting of hydrogen, OR A , halogen, cyano, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl and trihaloC 1-6 alkyl; each R A is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, phenyl, benzyl and 5-10 membered heterocyclyl, each optionally substituted by from 1 to 3 halogen atoms; and each R B is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, phenyl, benzyl and 5-10 membered heterocyclyl, each optionally substituted by from 1 to 3 halogen atoms; and each R C is independently selected from the group consisting of hydrogen and C 1-6 alkyl.