Patent ID: 8372974

Claim:
A method for making a compound of formula III wherein X2 is a leaving group, and R1 and R2 are substituents independently selected from hydrogen, an aromatic group and an aliphatic group, or taken together —N(R1)R2 can form a 4-11 membered aromatic or aliphatic ring, comprising reacting a compound of formula I with an amine of formula II [HN(R1)R2] to form a compound of formula III, wherein X1 is a leaving group selected from the group consisting of: phenyloxy optionally substituted by 1-5 suitable substituents, heterocyclyl N-oxy optionally substituted by 1-5 suitable substituents, and heteroaryl N-oxy optionally substituted by 1-5 suitable substituents; wherein said aromatic group, aliphatic group, or aromatic or aliphatic ring may be substituted with 1-3 suitable substituents selected from hydrogen, halo groups, perfluoroalkyl groups, perfluoroalkoxy groups, alkyl groups, alkenyl groups, alkynyl groups, hydroxy groups, oxo groups, alkylthio groups, arylthio groups, alkylsulfonyl groups, arylsulfonyl groups, heteroarylsulfonyl groups, alkylsulfonate groups, arylsulfonate groups, perfluoroalkylsulfonate groups, alkoxy groups, aryl and heteroaryl groups, cycloalkyl and heterocycloalkyl groups, aryloxy and heteroaryloxy groups, aralkyl and heteroaralkyl groups, aralkoxy and heteroaralkoxy groups, HO—(C═O)— groups, amino groups, alkyl- and dialkylamino groups, carbamoyl groups, alkylcarbonyl groups, alkoxycarbonyl groups, alkylaminocarbonyl groups, dialkylaminocarbonyl groups, sulfonamido groups, alkylsulfonamido groups, dialkylsulfonamido groups, amido groups, N-acyl groups, arylcarbonyl groups, aryloxycarbonyl groups, nitro and cyano.