Patent ID: 7888351

Claim:
A compound of Formula (I): wherein the asterisk * designates a chiral centre of (R) or (S) configuration; V is absent or is ethylene; W is —C(O)— or —S(O) l —; X is a linker having 1 to 12 in-chain atoms and comprising one or more linkages selected from —O—, —C(O)—, —S(O) l —, —N(R 9 )— and hydrocarbylene optionally substituted with 1, 2, 3, 4 or 5 R 11 ; Y is a linker selected from —O—, —N(R 9 )—, —C(O)—, —C(O)O—, —C(O)N(R 9 )—, —S(O) l — and S(O) l N(R 9 )—; R 1 is selected from hydrogen; —N(R 9 )(R 10 ) hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 11 ; hydrocarbyloxy optionally substituted with 1, 2, 3, 4 or 5 R 11 ; and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 11 ; or, when Y is —N(R 9 )—, R 1 and R 9 taken together with the nitrogen atom to which they are attached may form a heterocycle, wherein said heterocycle is bound to X via said nitrogen atom and is optionally substituted with 1, 2, 3, 4 or 5 R 11 ; R 2 and R 3 are each independently selected from R 8 , —OR 8 ; —C(O)R 8 ; —C(O)OR 8 and —S(O) l R 9 ; R 4 and R 5 are each independently selected from hydrogen, hydroxy, halogen and C 1-6 alkyl optionally substituted with 1, 2, 3, 4 or 5 R 11 ; R 6 is aryl or heteroaryl, either of which is optionally-substituted with 1, 2, 3, 4 or 5 R 11 ; R 8 is selected from hydrogen; hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 11 ; and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 11 ; R 9 and R 10 are each independently selected from R 8 , —OR 8 , —C(O)R 8 , —C(O)OR 8 and —S(O) l R 8 ; or R 9 and R 10 taken together with a nitrogen atom to which they are attached form heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 11 ; each R 11 is independently selected from R 12 ; hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 12 ; and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 12 ; R 12 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo, ═NR 13 , —OR 13 , —C(O)R 13 , —C(O)N(R 13 )R 14 , C(O)OR 13 , —OC(O)R 13 , —S(O) l R 13 , —S(O) l N(R 13 )R 14 , —N(R 13 )R 14 , —N(R 13 )N(R 13 )R 14 , —N(R 13 )C(O)R 14 and —N(R 13 )S(O) l R 13 ; R 13 and R 14 are each independently hydrogen or selected from hydrocarbyl and —(CH 2 ) k -heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from oxo, halogen, cyano, amino, hydroxy, C 1-6 alkyl and C 1-6 alkoxy; k is 0, 1, 2, 3, 4, 5 or 6; and l is 0, 1 or 2; or a pharmaceutically acceptable salt or prodrug thereof.