Patent ID: 8759528

Claim:
A compound of the formula I wherein either X is N and Y is CH, or X is CH and Y is N; Ar 1 is selected from the group consisting of: phenylene, pyridinylene and pyrimidinylene, wherein each of the beforementioned groups may be substituted with a substituent R A ; R A is selected from the group consisting of: H, F, Cl, Br, I, CN, OH, —NO 2 , C 1-4 -alkyl, C 2-4 -alkenyl, C 1-4 -alkyl-O—, C 1-4 -alkyl-C(═O)—, H 2 N—, H 2 N—C(═O)—, H 2 N—S(═O) 2 —, HO—C(═O)—, C 1-4 -alkyl-O—C(═O)—, phenyl and phenyl-C 1-3 -alkyl, wherein in each NH 2 -group, one or both hydrogen atoms may independently be replaced by C 1-4 -alkyl; R 1 is selected from the group consisting of: OH, C 1-4 -alkyl-O—, C 3-7 -cycloalkyl-O—, C 3-7 -cycloalkyl-C 1-3 -alkyl-O—, H 2 N —, (C 1-4 -alkyl)NH—, (C 1-4 -alkyl) 2 N—, C 3-7 -cycloalkyl-NH—, C 3-7 -cycloalkyl-N(C 1-4 -alkyl)-, C 1-4 -alkyl-C(═O)—, C 1-4 -alkyl-S(═O) 2 -, HO—C(═O)—, C 1-4 -alkyl-O —C(═O)—, H 2 N—C(═O)—, (C 1-4 -alkyl)HN—C(═O)— and (C 1-4 -alkyl) 2 N—C(═O)—, wherein each alkyl or cycloalkyl may be optionally substituted with one or more substituents selected from F and OH; Ar 2 is selected from the group consisting of: phenylene and a 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 heteroatoms selected from N, O, or S, R 2 is selected from the group consisting of: H and C 1 -alkyl; R 3 is selected from the group consisting of: H and methyl; R 4 is selected from the group consisting of: H, C 1-4 -alkyl, C 3-7 -cycloalkyl, C 3-7 -cycloalkyl-C 1-3 -alkyl, phenyl, and phenyl-C 1-3 -alkyl, wherein each alkyl and cycloalkyl may be optionally substituted with one or more groups independently selected from the group consisting of: F, Cl, Br, CN, OH and —O—(C 1-4 -alkyl), and wherein each phenyl group may be optionally substituted with one or more substituents L; or R 3 and R 4 may be connected with each other and together with the N-atom to which they are attached form a group selected from the group consisting of: azetidinyl, pyrrolidinyl, piperidinyl and azepanyl, wherein in each of these groups one or two CH 2 -groups may be independently replaced by N, O, S, C(═O) or SO 2 , and/or wherein each of these groups may be substituted by one or more C 1-4 -alkyl; and L is selected from the group consisting of: F, Cl, Br, CN, OH, C 1 -alkyl-, C 1-4 -alkyl-O—, C 1-4 -alkyl-S—, C 1-4 -alkyl-S(═O) 2 -, H 2 N—, (C 1-4 -alkyl)NH—, (C 1-4 -alkyl) 2 N— and heterocyclyl, wherein each alkyl may be optionally substituted with one or more F-atoms and/ or with a substituent selected from OH, C 1-3 -alkyl-O— and CN; and wherein two substituents L attached to an aryl or heteroaryl group may be linked to each other and form a C 2-5 -alkylene bridging group in which 1 or 2 —CH 2 -groups may be replaced by a group independently of each other selected from O, S, NH and N(C 1-4 -alkyl)-, wherein the C 2-5 -alkylene bridging group is optionally be substituted by 1 or 2 C 1-3 -alkyl groups; or a pharmaceutically acceptable salt thereof.