Patent ID: 8236953

Claim:
A process for the preparation of a compound of formula (I): wherein: A is phenyl or pyridyl, optionally substituted with halogen, C (1-4) alkyl or C (1-4) alkoxy; R 1 and R 2 are independently H or C (1-4) alkyl; R 3 is an optionally substituted phenyl, wherein when R 3 is a substituted phenyl, said substituted phenyl has 1, 2 or 3 substituents, each independently selected from halogen, C (1-4) alkyl, C (1-4) alkoxy, C (3-7) cycloalkyl, hydroxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, phenyl, NH 2 , NHR 5 , NR 5 R 6 , NHCOR 5 , NHSO 2 R 5 , C(O)CF 3 , C(O)C (1-4) alkyl, C(O)C (3-7) cycloalkyl, C(O)OC (1-4) alkyl, C(O)OC (3-7) cycloalkyl, OC(O)C (1-4) alkyl, OC(O)C (3-7) cycloalkyl, CONH 2 , CONHR 5 , CONR 5 R 6 , SOR 6 , SO 2 CF 3 , SO 2 R 6 , OSO 2 R 6 , OSO 2 CF 3 , SO 2 NH 2 , SO 2 NHR 5 and SO 2 NR 5 R 6 ; wherein R 5 and R 6 may be the same or different and are independently selected from C (1-4) alkyl, phenyl optionally substituted with halogen, and 5 or 6 membered heteroaryl optionally substituted with halogen; Y is NH, O, CH 2 or a bond; and R 4 is C (1-4) alkyl or C (1-4) alkoxy C (1-4) alkyl; or a pharmaceutically acceptable salt thereof, which method comprises: (a) reacting a compound of formula (II): wherein Q is hydrogen or a suitable nitrogen protecting group, with a compound of formula (III): using reaction conditions suitable for urea formation; and (b) thereafter optionally carrying out one or both of the following reactions: 1. removing any protecting group; 2. forming a suitable pharmaceutical acceptable salt of the compound so formed.