Patent ID: 7601528

Claim:
A crystal of beta secretase co-crystallized with a ligand, wherein the amino acid sequence of said beta secretase is SEQ ID NO:1, said crystal has space group symmetry P3 2 21, a unit cell defined by dimensions a, b, c, α, β and γ, wherein a is 99.4±35 Å, b is 99.4±35 Å, c is 117±35 Å, α=β=90°, γ=120°, and wherein said ligand is bound at the active site of said beta secretase, and is N1-((2S,3R)-4-(3-iodobenzylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)-5-methyl-N3,N3-dipropylbenzene-1,3-diamide.