Patent ID: 7291732

Claim:
A compound of Formula I: or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein: ring D is selected from phenyl and cyclohexene with double bond a-b; ring B and ring F, independently, and each together with the carbon atoms to which they are attached, are selected from phenyl, pyridyl and thienyl; with the proviso that at least one of rings B and F is phenyl; G-X—W is selected from: a) -(A 1 A 2 )C—NH—C(B 1 B 2 )—; b) —CH 2 —C(═O)—NH—; and c) —NH—C(═O)—CH 2 —; R 3 and R 5 are H; R 2 and R 4 are each independently selected from: a) H, —CN, —OH, —OR 7 , Br, I, —O(CH 2 ) p OR 8 ,F, Cl, —CH 2 OR 8 , —NR 9 R 10 , —(CH 2 ) p NR 9 R 10 and; b) alkyl of 1 to 8 carbons, alkenyl of 2 to 8 carbons, and alkynyl of 2 to 8 carbons, wherein: 1) each alkyl, alkenyl, or alkynyl group is unsubstituted; or 2) each alkyl, alkenyl or alkynyl group is substituted with 1 to 3 groups selected from pyridyl, F, Cl, Br, I, —CN, —NR 9 R 10 , —NR 8 C(═S)NR 9 R 10 , —NR 8 S(═O) 2 R 7 , and —CO 2 R 12 ; R 12 is selected from H, alkyl of 1 to 6 carbons, —OH, and alkoxy of 1 to 6 carbons; Q is selected from —NR 6 , —O—, and —S—; R 6 is selected from H, —SO 2 R 7 , —CO 2 R 7 , —C(═O)R 7 , —C(═O)NR 9 R 10 , alkyl of 1-8 carbons, alkenyl of 2-8 carbons, and alkynyl of 2-8 carbons; and either 1) each alkyl, alkenyl, or alkynyl group is unsubstituted; or 2) each alkyl, alkenyl, or alkynyl group independently is substituted, as defined for R 2 , R 3 , R 4 , and R 5 in e) above; R 7 is substituted or unsubstituted alkyl having from 1 to 6 carbons; R 8 is selected from H and alkyl having from 1 to 6 carbons; R 9 and R 10 are each independently selected from H, unsubstituted alkyl of 1 to 6 carbons, and substituted alkyl of 1 to 6 carbons; Y is selected from: a) an unsubstituted alkylene of 1-3 carbons; and b) a functional group selected from —CH═CH—, —CH 2 Z- and -ZCH 2 —, where Z is selected from —O— and —S—; A 1 and A 2 are selected from H, H; H, OR 12 ; H, —SR 12 ; H, —N(R 12 ) 2 ; and a group where A 1 and A 2 together form a moiety selected from ═O, ═S, and ═NR 12 ; and, B 1 and B 2 are selected from H, H; H, —OR 12 ; H, —SR 12 ; H, —N(R 12 ) 2 ; and a group where B 1 and B 2 together form a moiety selected from ═O, ═S, and ═NR 12 ; p is from 1 to 4; with the proviso that at least one of the pairs A 1 and A 2 , or B 1 and B 2 , form ═O; with the further proviso that when rings B and F are phenyl, Y is —CH 2 Z- or -ZCH 2 —.