Patent ID: 8835469

Claim:
Compounds having the structure of Formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, or diastereomers thereof, wherein X═O, CH 2 , S; Y═O, CH 2 , CR 1 R 2 , NR 1 , NCOR 1 ; HET-1 is a 5- or 6-membered, C-linked heteroaryl ring containing a nitrogen atom in 2-position relative to the amide nitrogen to which the ring is attached and optionally containing 1 or 2 further ring heteroatoms independently selected from O, N and S, which ring is optionally substituted on available carbon, nitrogen and/or sulfur atom with one or more R 3 ; Ring ‘Z’ is selected from phenyl or ‘HET-3’, wherein ‘HET-3’ is a 5- or 6-membered heteroaryl or heterocyclic ring containing 1, 2 or 3 hetero atoms independently selected from O, S and N and wherein either the phenyl or the ‘HET-3’ independently is further substituted with one or more of R 3 ; ‘Het-2’ is selected from the following cyclic groups R 3 at each occurrence is independently selected from hydrogen, halogen, cyano, optionally substituted groups selected from —NR 1 R 2 , C (1-6) alkyl, C (2-6) alkenyl, C (2-6) alkyne, C (1-6) haloalkyl, C (1-6) alkoxy, C (1-6) haloalkoxy, —C (3-6) cycloalkyl, —(CH 2 ) p —COOR 1 , —(CH 2 ) p —CONR 1 R 2 ,CONHR 1 , perfluoroalkyl, C (1-4) alkoxyalkyl, aryl, arylalkyl, amino, aminoalkyl, alkylamino, alkylaminoalkyl, alkylC (1-4) alkoxy, wherein each of R 3 when further substituted, the substituents are independently selected from amino, halo, cyano, nitro, hydroxyl, alkoxy groups; and R 1 and R 2 at each occurrence is independently selected from hydrogen, halogen, amino, cyano, nitro, optionally substituted groups selected from C (1-4) alkyl, C (2-4) alkenyl, C (2-4) alkynyl, C (1-4) alkoxy, C (1-4) haloalkyl groups or alternatively, when possible, R 1 & R 2 together with the atom to which they are attached may further form a cycloalkyl or heterocyclic ring containing heteroatoms selected from O, S and N; m=0, 1, 2; n=0, 1, 2; p=0, 1, 2.