Patent ID: 8053458

Claim:
A compound of formula I: wherein: R 1 is selected from the group consisting of aryl, benzyl, C 3-8 cycloalkyl, straight chain C 1-l0 alkyl, C 3-8 cycloalkylC 1-6 alkyl, arylcarbonyl, arylC 1-6 alkylC 3-8 cycloalkylcarbonyl, and C 1-10 alkylcarbonyl; wherein said aryl, or benzyl is optionally substituted with one or more substituents each independently selected from C 1-6 alkyl, C 1-6 perfluoroalkyl, halogen, hydroxy, C n H x F y alkoxy wherein n is 1-4, x is 0-8, y is 1-9 and x+y is 2n+1, C 1 -C 6 alkoxy, nitro, or aryl; R 2 is selected from the group consisting of C 1-6 alkyl, C 3-8 cycloalkyl, and aryl wherein said aryl is optionally substituted with one or more substituents each independently selected from C 1-6 alkyl, C 1-6 perfluoroalkyl, halogen, hydroxy, C n H x F y alkoxy wherein n is 1-4, x is 0-8, y is 1-9 and x+y is 2n+1, C 1 -C 6 alkoxy, nitro, or aryl; R 3 is selected form the group consisting of aryl, C 3-8 cycloalkyl, C 1-6 alkyl and hetero-aryl wherein said aryl or hetero-aryl is optionally substituted with one or more substituents each independently selected from C 1-6 alkyl, C 1-6 perfluoroalkyl, halogen, hydroxy, C n H x F y alkoxy wherein n is 1-4, x is 0-8, y is 1-9 and x+y is 2n+1, C 1 -C 6 alkoxy, nitro, or aryl; R 4 is selected form the group consisting of H, aryl, arylC 2-6 alkyl, benzyl, C 1-6 perfluoroalkyl, C 3-8 cycloalkyl and C 1-6 alkyl wherein said aryl is selected from phenyl, biphenyl, anthracenyl, phenanthrenyl, fluorenyl, indenyl, pentenyl, azulenyl, biphenylenyl and partially hydrogenated derivatives of the same, and said aryl or benzyl is optionally substituted with one or more substituents each independently selected from C 1-6 alkyl, C 1-6 perfluoroalkyl, halogen, hydroxy, C n H x F y alkoxy wherein n is 1-4, x is 0-8, y is 1-9 and x+y is 2n+1, C 1 -C 6 alkoxy, or aryl; R 5 is H, C 1-6 alkyl, or C 3-8 cycloalkyl; and with the proviso that (a) when R 1 and R 4 are phenyl or 4-chlorophenyl, and R 5 is hydrogen then R 2 and R 3 are other than methyl simultaneously; (a) when R 1 is phenyl or 4-chlorophenyl and R 4 and R 5 are hydrogen then R 2 and R 3 are other than methyl simultaneously, or a stereoisomer or pharmaceutically acceptable salt thereof.