Patent ID: 7598412

Claim:
A compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: A is C(O) or SO 2 ; R C and R D taken together form a 3-6 membered cycloalkyl ring; n is 2 or 3; Z is wherein, W is pyridyl, pyrazolyl, oxazazolyl, furanyl, thienyl, isoxazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, indazolyl, quinolinyl, isoquinolinyl or cinnolinyl and m is 0 to 5; R B is (C1-C4)alkoxy; R Z is independently selected from R 1 , R 2 , R 4 , or R 5 , wherein: R 1 is R 6 , ((C1-C4)aliphatic)-Y, or Y; and Y is halo, CN, NO 2 , CF 3 , OCF 3 , OH, SR 6 , S(O)R 6 , SO 2 R 6 , NH 2 , NHR 6 , N(R 6 ) 2 , COOH, COOR 6 or OR 6 ; R 2 is an aliphatic, wherein each R 2 comprises up to 2 substituents independently selected from R 4 , or R 5 ; R 4 is OR 5 , OR 6 , OC(O)R 6 , OC(O)R 5 , OC(O)OR 6 , OC(O)OR 5 , OC(O)N(R 6 ) 2 , OC(O)N(R 5 ) 2 , OC(O)N(R 6 R 5 ), SR 6 , SR 5 , S(O)R 6 , S(O)R 5 , SO 2 R 6 , SO 2 R 5 , SO 2 N(R 6 ) 2 , SO 2 N(R 5 ) 2 , SO 2 NR 5 R 6 , SO 3 R 6 , SO 3 R 5 , C(O)R 5 , C(O)OR 5 , C(O)R 6 , C(O)OR 6 , C(O)N(R 6 ) 2 , C(O)N(R 5 ) 2 , C(O)N(R 5 R 6 ), C(O)N(OR 6 )R 6 , C(O)N(OR 5 )R 6 , C(O)N(OR 6 )R 5 , C(O)N(OR 5 )R 5 , C(NOR 6 )R 6 , C(NOR 6 )R 5 , C(NOR 5 )R 6 , C(NOR 5 )R 5 , N(R 6 ) 2 , N(R 5 ) 2 , N(R 5 R 6 ), NR 5 C(O)R 5 , NR 6 C(O)R 6 , NR 5 C(O)R 6 , NR 6 C(O)R 5 , NR 6 C(O)OR 6 , NR 5 C(O)OR 6 , NR 6 C(O)OR 5 , NR 5 C(O)OR 5 , NR 6 C(O)N(R 6 ) 2 , NR 6 C(O)NR 5 R 6 , NR 6 C(O)N(R 5 ) 2 , NR 5 C(O)N(R 6 ) 2 , NR 5 C(O)NR 5 R 6 , NR 5 C(O)N(R 5 ) 2 , NR 6 SO 2 R 6 , NR 6 SO 2 R 5 , NR 5 SO 2 R 5 , NR 5 SO 2 R 6 , NR 6 SO 2 N(R 6 ) 2 , NR 5 SO 2 N(R 6 ) 2 , NR 6 SO 2 NR 5 R 6 , NR 6 SO 2 N(R 5 ) 2 , NR 5 SO 2 NR 5 R 6 , NR 5 SO 2 N(R 5 ) 2 , N(OR 6 )R 6 , N(OR 6 )R 5 , N(OR 5 )R 5 , or N(OR 5 )R 6 ; R 5 is a cycloaliphatic, aryl, heterocyclic, or heteroaryl ring, wherein each R 5 is optionally substituted with up to 3 R 1 substituents; and R 6 is H or aliphatic, provided that when A is C(O), then the following compounds are excluded: ring W together with R Z R C & R D together and m ring B with R B & n cyclopentyl benzofuran-2-yl 3,4-dimethoxyphenyl cyclohexyl benzofuran-2-yl 3,4-dimethoxyphenyl cyclopentyl diphenylmethyl 3,4-dimethoxyphenyl cyclopentyl 5-bromo-furan-2-yl 3,4-dimethoxyphenyl.