Patent ID: 8178575

Claim:
A compound having formula (IA) or a pharmaceutically acceptable salt thereof: wherein R is the following formula: wherein R 1 is a member selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclo alkyl, aryl, heteroaryl, —C(O)NR 3 R 4 , —C(O)R 3 and —C(O)OR 3 , wherein the alkyl, cycloalkyl, heterocyclo alkyl, aryl or heteroaryl may be substituted with one or more groups selected from the group consisting of alkyl, aryl, hydroxyl, amino, alkoxyl, aryloxyl and heterocyclo alkyl; R 2 is a member selected from the group consisting of hydrogen and methyl; R 3 and R 4 are each independently a member selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl and heterocycle alkyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl or heterocyclo alkyl may be substituted with one or more groups selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, alkoxyl, cycloalkoxyl, aryloxyl, heteroaryloxyl, halogen, hydroxyl, amino, cyano, hydroxyalkyl, heterocyclo alkyl, heterocyclo alkoxyl, trifluoromethyl, carboxylic acid and carboxylic ester; and R 3 and R 4 are attached together with the N atom to form a 3 to 8 membered hetero ring, wherein the 3 to 8 membered hetero ring may contain one or more heteroatoms selected from the group consisting of N, O and S atom, and the 3 to 8 membered rings may be substituted with one or more groups selected from the group consisting of alkyl, aryl, heteroaryl, haloalkyl, haloalkoxyl, hydroxyl, amino, cyano, alkoxyl, aryloxyl, hydroxyalkyl, heterocyclo alkyl, carboxylic acid,carboxylic ester, halogen and —NR 3 R 4 ; and R 5 is a member selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl and heterocyclo alkyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl or heterocyclo alkyl may be substituted with one or more groups selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, alkoxyl, cycloalkoxyl, aryloxyl, heteroaryloxyl, halogen, hydroxyl, amino, alkylamino, cyano, hydroxyalkyl, heterocyclo alkyl, heterocyclo alkoxyl, carboxylic acid and carboxylic ester; R 6 and R 7 are each independently a member selected from the group consisting of alkyl, aryl, heteroaryl, haloalkyl, haloalkoxyl, hydroxyl, amino, cyano, alkynyl, alkoxyl, aryloxyl, hydroxyalkyl, heterocyclo alkyl, carboxylic acid, carboxylic ester and halogen; and W is C.