Patent ID: 7108969

Claim:
A method of monitoring a gene expression profile associated with oral cancer comprising: contacting a first array of probes with a first population of nucleic acids derived from a human subject from one or more cells obtained from malignant oral tissue; contacting a second array of probes with a second population of nucleic acids derived from the human subject from one or more cells obtained from normal oral tissue; and determining relative hybridization of the first array of probes to the first population of nucleic acids relative to hybridization of the second array of probes to the second population of nucleic acids, wherein at least one nucleic acid that hybridizes differently is encoded by a gene of a gene expression profile that is associated with oral cancer, wherein the gene of the gene expression profile is selected from the group consisting of p-53 responsive gene 2, beta A inhibin, human alpha-1 collagen type I gene, placental protein 11, BENE protein, neuromedin U, flavin containing monooxygenase 2, runt-related transcription factor 1, alpha 2 collagen type I, fibrillin 1, absent in melanoma 1, nonvoltage-gated 1 alpha sodium channel, protein tyrosine kinase 6 and epithelial membrane protein 1.