Patent ID: 8691221

Claim:
A method for treating and/or preventing chronic pain in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a humanized anti-TrkA antibody capable of inhibiting the binding between nerve growth factor (NGF) and TrkA, wherein the variable region of the antibody light chain comprises the sequence of SEQ ID NO:1 comprising all three complementarity determining regions (CDRs) having a sequence selected from aa. 24 to aa. 33 of SEQ ID NO: 1; from aa. 49 to aa. 55 of SEQ ID NO: 1; and from aa. 88 to aa. 96 of SEQ ID NO:1; and wherein the variable region of the antibody heavy chain comprises essentially the sequence of SEQ ID NO: 2 comprising all three of the complementarity determining regions (CDRs) having a sequence selected from aa. 26 to aa. 35 of SEQ ID NO: 2; from aa. 50 to aa. 66 of SEQ ID NO: 2; from aa. 99 to aa. 112 of SEQ ID NO: 2; and variants of the sequence from aa. 99 to aa. 112 of SEQ ID NO: 2, thereby treating and/or preventing chronic pain in said subject.