Patent ID: 8419710

Claim:
A method for infusing first and second fluid compositions to a target location of a subject using an implantable infusion system including an infusion device and a catheter, the infusion device having a reservoir and a catheter access port, the catheter having a delivery region and being operably couplable to the infusion device such that fluid stored in the reservoir or infused into the access port is deliverable via the delivery region to a target location of the subject, the method comprising: introducing the delivery region of the catheter into the intrathecal space of the subject at a lumbar level of the spinal canal and advancing the delivery region rostrally in the intrathecal space of the spinal canal to a level of C3 or higher; introducing into the reservoir the first fluid composition comprising a first polypeptide configured to function as an endogenous protein; delivering the first fluid composition to the target location via the delivery region of the catheter at a substantially constant low infusion rate sufficient to maintain catheter patency, with intermittent boluses at a higher rate; and delivering to the target location the second fluid composition, wherein the second fluid composition comprises a polynucleic acid encoding a second polypeptide configured to function as the endogenous protein and wherein the second fluid composition is infused into the catheter access port, wherein the first and second polypeptides are the same or different.