Patent ID: 8093214

Claim:
A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to congestive heart failure disease, or for restoring tissue adversely affected by said disease, in a subject, comprising administering to a subject having congestive heart failure disease an effective amount of a composition comprising a peptide agent comprising amino acid sequence LKKTET (SEQ ID NO: 1) or a conservative variant thereof, LKKTNT (SEQ ID NO: 2) or a conservative variant thereof, Thymosin β4 (Tβ4), a Tβ4isoform, KLKKTET (SEQ ID NO: 3), LKKTETQ (SEQ ID NO: 4), oxidized Tβ4, an N-terminal variant of Tβ4, a C-terminal variant of Tβ4, Tβ4 ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DNasel, vilin, fragmin, severin, capping protein, β-actinin or acumentin, in said tissue, so as to inhibit said tissue deterioration, injury or damage due to said disease, or restore tissue adversely affected by said disease, wherein administration of said peptide agent results in at least one of a reduction of left ventricular systolic pressure (LVSP) of a heart, reduction in left ventricular end diastolic pressure (LVEDP) of a heart, attenuation of left ventricular end systolic volume of a heart, attenuation of left ventricular end diastolic volume of a heart, an increase in rate of change (velocity) in left ventricular pressure-rise with time (dP/dt) of a heart, an increase in rate of change (velocity) in left ventricular pressure decrease with time (pdP/dt) of a heart, attenuation of pulmonary edema following heart muscle damage/injury, or attenuation of muscle thickness of a heart left ventricle.