Patent ID: 8652504

Claim:
A method for making a solid polymer composition for controlled release of a bioactive agent comprising: a) casting or spraying onto a removable solid substrate the following polymer layers: i) a carrier layer comprising a liquid dispersion or solution in a first solvent of at least one bioactive agent and a biodegradable, biocompatible polymer; ii) a coating layer of a liquid solution in a second solvent of a biodegradable, biocompatible polymer; and iii) a liquid barrier layer intermediate between the carrier layer and the coating layer, wherein the barrier layer is insoluble in the first or second solvent, but dissolves under physiological conditions; b) drying each layer before casting or spraying the next layer thereon, wherein the biodegradable, biocompatible polymer of a) i) comprises at least one or a blend of poly(ester-amide)s (PEAs) having formula (I) or formula (IV); and c) removing the removable solid substrate from the composition prior to use, wherein the PEA of formula (I) is: wherein n ranges from about 5 to about 100; R 1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)(C 1 -C 8 )alkane, 3,3′-(alkanedioyldioxy)dicinnamic acid, 4,4′-(alkanedioyldioxy)dicinnamic acid, residues of α,ω-alkylene dicarboxylates of formula (III): (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene and combinations thereof; R 5 and R 6 are independently selected from (C 2 -C 12 )alkylene and (C 1 -C 12 )alkenylene; the R 3 s in individual n monomers are independently selected from hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 6 -C 10 )aryl(C 1 -C 6 )alkyl and —(CH 2 ) 2 S(CH 3 ); and R 4 is independently selected from (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene, (C 2 -C 8 )alkyloxy (C 2 -C 20 )alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II): and combinations thereof; and wherein the PEA of formula (IV) is: wherein n ranges from about 5 to about 150, m ranges about 0.1 to 0.9: p ranges from about 0.9 to 0.1; R 1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)(C 1 -C 8 )alkane, 3,3′-(alkanedioyldioxy)dicinnamic acid, 4,4′-(alkanedioyldioxy)dicinnamic acid, residues of α,ω-alkylene dicarboxylates of formula (III), (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene, and combinations thereof; R 5 and R 6 in Formula (III) are independently selected from (C 2 -C 12 )alkylene and (C 2 -C 12 )alkenylene; each R 2 is independently selected from hydrogen, (C 1 -C 12 )alkyl, (C 2 -C 8 )alkyloxy(C 2 -C 20 ) alkyl, (C 6 -C 10 )aryl, and a protecting group; the R 3 s in individual m monomers are independently selected from hydrogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 )alkenyl, (C 6 -C 10 )aryl(C 1 -C 6 )alkyl and —(CH 2 ) 2 S(CH 3 ); and R 4 is independently selected from (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene, (C 2 -C 8 )alkyloxy (C 2 -C 20 )alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of formula (II), and combinations thereof, and R 7 is independently selected from (C 1 -C 20 ) alkyl and (C 2 -C 20 alkenyl.