Patent ID: 7566791

Claim:
Compounds of formula (I): wherein: R 1 is hydrogen, C 2 -C 6 alkyl, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl, wherein the alkyl and cycloalkyl groups may be optionally substituted with halogen, —CN, C 1 -C 6 alkoxy, —OH, —NH 2 , or —NO 2 ; R 2 is hydrogen, C 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, phenyl, benzyl, or CH 2 -naphthyl, wherein the alkyl group and the rings of the cycloalkyl, phenyl, benzyl, and napthyl groups may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 3 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, —S—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 6 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 3 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, —NH 2 , or —NO 2 ; R 4 is C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, phenyl, or naphthyl, wherein the rings of the cycloalkyl, phenyl, and napthyl groups may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 3 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, —S—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OCHF 2 , —CN, —COOH, CH 2 CO 2 H, —C(O)CH 3 , —C(O)OR 6 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 5 is thienyl, CH 2 -thienyl, furanyl, CH 2 -furanyl, oxazoyl, CH 2 -oxazoyl, benzo[b]furan-2-yl, benzo[b]thien-2-yl, or benzo[1,3]dioxol-5-yl, the rings of the thienyl, furanyl, oxazoyl, benzofuranyl, and benzothienyl, groups may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, —S—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, phenoxy, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 6 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 , wherein the phenoxy group may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 3 alkyl, or C 1 -C 3 perfluoroalkyl; and R 6 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, or benzyl; or a pharmaceutically acceptable salt or ester form thereof.