Patent ID: 7915295

Claim:
A compound of the formula Z: where; A is CH or N; R 1 is a substituent to a carbon atom in the ring containing A selected from —S(═O) p Ra, where Ra is —C 1 -C 4 alkyl, —ORx, —NRxRx, —NHNRxRx, —NHNHC(═O)ORx, —NRxOH; —C(═O)—Rb, where Rb is —C 1 -C 4 -alkyl, ORx, —NRxRx, —NHNRxRx, —NHC 1 -C 3 -alkyl-C(═O)ORx; —NRxRc, where Rc is H, C 1 -C 4 alkyl, —NRxRx; —C(═O)Rd, —CN, S(═O) p Rx where Rd is C 1 -C 4 -alkyl, —ORx, —NRxRx, —C 1 -C 3 -alkyl-O—C 1 -C 3 alkylC(═O)ORx; —C 1 -C 3 -alkyl-COORx; —C 1 -C 3 alkyl-ORx; —(O—C 1 -C 3 alkyl) q -O-Rx; a 5 or 6 membered aromatic ring have 1-3 hetero atoms; p and q are independently selected from 1 or 2; Rx is independently selected from H, C 1 -C 4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a pyrrolidine, piperidine, piperazine or morpholine ring; R 2 is a substituent to a carbon atom in the ring containing A and is H, halo, cyano, C 1 -C 4 -alkyl, haloC 1 -C 4 -alkyl; L is —O—, —S(═O) 1 — or —CH 2 —, where r is 0, 1 or 2; R 3 is H, C 1 -C 3 alkyl; R 4 -R 7 are independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, haloC 1 -C 6 alkyl, C 1 -C 6 alkanoyl, haloC 1 -C 6 alkanoyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, C 1 -C 6 alkyloxyC 1 -C 6 alkyl, haloC 1 -C 6 alkyloxyC 1 -C 6 alkyl, hydroxyC 1 -C 6 alkyl, aminoC 1 -C 6 alkyl, carboxyC 1 -C 6 alkyl, cyanoC 1 -C 6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto; X is —(CR 8 R 8 ′) n -D-(CR 8 R 8 ′) m —; T is O or S; D is a bond, —NR 9 —, —O—, —S—, —S(═O)— or —S(═O) 2 —; n and m are independently 0, 1 or 2, provided that they are not both 0 when D is a bond; R 8 and R 8 ′ are independently H, C 1 -C 3 alkyl, haloC 1 -C 3 alkyl, hydroxy, or R 8 and R 8 ′ together with their adjacent C atom is —C(═O)— R 9 is independently H, C 1 -C 3 alkyl; and pharmaceutically acceptable salts and prodrugs thereof; with the proviso that R 1 as —C(═O)Rb is not morpholinoketo-.