Patent ID: 7648961

Claim:
A method of accelerating the start of growth of quiescent follicles in non-menopausat women comprising administering to a patient in need thereof a medicament comprising a somatostatin antagonist analog having the general formula (III) in which: A 1 is an optionally substituted aromatic α-amino acid; A 2 is an optionally substituted aromatic α-amino acid; A 3 is Dab, Dap, Lys, or Orn; A 4 is β-Hydroxyvaline, Ser, Hser, or Thr; A 5 is an optionally substituted aromatic D- or L- α-amino acid; and Y 1 is OH, NH 2 or NHR 1 , R 1 is (C 1-6 )alkyl; each aromatic α-amino acid being optionally substituted with one or more substituents independently selected from a halogen atom, NO 2 , OH, CN, (C 1-6 ) alkyl, (C 2-6 ) alkenyl, (C 2-6 ) alkynyl, (C 1-6 ) alkoxy, Bzl, O-Bzl or NR 9 R 10 , wherein R 9 and R 10 are each independently H, O, or (C 1-6 ) alkyl; and each nitrogen atom of a peptide amide bond and the amino group of A 1 are optionally substituted with a methyl group, with the proviso that there is at least one said methyl group in a peptide of general formula (III); or a phannaceutic ally acceptable salt or protected form, or a combination thereof.