Patent ID: 8410286

Claim:
A compound of formula (I): wherein: 1) A and Ar are independently selected from the group consisting of: aryl, and substituted aryl, 2) L is O—CO—NH; 3) R 1 is selected from the group consisting of: H, R 6 , COR 6 , SO 2 R 6 , in which R 6 is chosen from H, OR 7 , NR 8 R 9 , alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, in which R 7 is chosen from H, phenyl and alkyl, and in which R 8 and R 9 are independently selected from the group consisting of H, alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, or alternatively R 8 and R 9 are linked together to form a saturated 5- to 8-membered ring containing from 0 to 3 heteroatoms chosen from O, S and N; 4) X is selected from the group consisting of: O and NH; 5) R 3 is selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl; 6) R 4a is selected from the group consisting of: H and (C1-C4)alkyl; 7) R 4b is selected from the group consisting of: H and (C1-C4)alkyl; 8) R 5 is selected from the group consisting of H, halogen, R 10 , CN, O(R 10 ), OC(O)(R 10 ), OC(O)N(R 10 )(R 11 ), OS(O 2 )(R 10 ), N(R 10 )(R 11 ), N═C(R 10 )(R 11 ), N(R 10 )C(O)(R 11 ), N(R 10 )C(O)O(R 11 ), N(R 12 )C(O)N(R 10 )(R 11 ), N(R 12 )C(S)N(R 10 )(R 11 ), N(R 10 )S(O 2 )(R 11 ), C(O)(R 10 ), C(O)O(R 10 ), C(O)N(R 10 )(R 11 ), C(═N(R 11 ))(R 10 ), C(═N(OR 11 ))(R 10 ), S(R 10 ), S(O)(R 10 ), S(O 2 )(R 10 ), S(O 2 )O(R 10 ), S(O 2 )N(R 10 )(R 11 ); in which each R 10 , R 11 , R 12 is independently selected from the group consisting of H, alkyl, alkylene, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, substituted alkyl, substituted alkylene, substituted alkynyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl and substituted heterocyclyl.