Patent ID: 8841345

Claim:
A method of treating premature ejaculation in a patient complaining of premature ejaculation comprising the steps of: administering meatally to a patient in need of treatment of premature ejaculation an ejaculation latency prolonging amount of a semi-solid composition comprising: 0.75 percent by weight based on the weight of the composition of bupivacaine as a topical anesthetic; 0.4 percent by weight based on the total weight of the composition of a vasoactive prostaglandin selected from the group consisting of prostaglandin E 1 , a pharmaceutically acceptable salt thereof a lower alkyl ester thereof wherein the lower alkyl is a straight chain or branched chain alkyl containing one to four carbon atoms, and a mixture thereof; a polymeric thickener selected from the group consisting of a shear-thinning polysaccharide gum and a shear-thinning polyacrylic acid polymer; a lipophilic component that is selected from the group consisting of an aliphatic C 1 to C 8 alcohol, an aliphatic C 8 to C 30 ester, a liquid polyol and a mixture thereof; wherein the composition further comprises 0.5 percent by weight based on the weight of the composition a penetration enhancer that is dodecyl 2-(N,N-dimethylamino)-propionate or a pharmaceutically acceptable salt; water; and a buffer system that provides a buffered pH value for said composition in the range of about 3 to about 7.4; wherein administering the semi-solid composition provides about 0.1 mg to about 0.5 mg of vasoactive prostaglandin and confers prolongation of baseline ejaculation latency time to the patient, thereby treating premature ejaculation in the patient.