Patent ID: 7705007

Claim:
The compound of formula I and the pharmaceutically acceptable salts and esters thereof, wherein Ring A is: X 1 is selected from the group consisting of lower alkoxy, and lower alkoxy substituted by trifluoromethyl or fluorine; X 2 is selected from the group consisting of hydrogen, thioalkyl, lower alkyl, lower alkoxy, morpholino, and —NX 3 X 4 ; X 3 and X 4 are independently selected from the group consisting of hydrogen, lower alkyl, lower alkyl substituted by lower alkoxy or cyano, and lower alkoxy; Y and Z are independently selected from the group consisting of: carbon, and nitrogen; V 1 and V 2 are independently selected from the group consisting of halogen, cyano, and acetylene; R is selected from the group consisting of piperidinyl substituted by five or six membered heterocycle, piperidinyl substituted by —NX 3 X 4 , and wherein n=1 or 2, R 1 can be one or more substituents selected from the group consisting of hydrogen, oxo, lower alkyl substituted by R 2 , —C(O)R 3 , and —SO 2 -lower alkyl; R 2 is selected from the group consisting of hydroxy, lower alkoxy, trifluoromethyl, -cyano, —NH—SO 2 -lower alkyl, —NH—C(O)-lower alkyl, —C(O)-lower alkyl, —C(O)R 4 , —C(O)—NX 3 X 4 , —SO 2 -lower alkyl, —SO 2 —NX 3 X 4 , R 3 is selected from the group consisting of five membered heterocycle, lower alkyl, lower alkoxy, and lower alkyl substituted by lower alkoxy and R 4 is selected from the group consisting of hydroxy, lower alkoxy, morpholino, and —NX 3 X 4 with the proviso that at least one of Y and Z above is nitrogen.