Patent ID: 8278446

Claim:
A process for preparing a compound of Formula (I) and an acid salt thereof: wherein L is selected from a bond, C 1-6 alkyl or F—C 1-6 alkyl; Ar is selected from aryl, heteroaryl, benzofused-heterocyclyl or benzofused-C 3-12 cycloalkyl; R A is selected from C═N—O—R 1 ; R 1 is selected from hydrogen, C 1-8 alkyl, C 1-8 alkenyl, C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, hydroxy-C 1-8 alkyl, hydroxy-C 1-8 alkoxy, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkyl-amino-C 1-8 alkyl, C 1-8 alkyl-sulfonyl-C 1-8 alkyl, C 1-8 alkyl-sulfonyloxy-C 1-8 alkyl, aryl, aryl-C 1-8 alkyl, aryloxy-C 1-8 alkyl, heterocyclyl-C 1-8 alkyl, heterocyclyl-carbonyl-C 1-8 alkyl, benzofused-heterocyclyl-C 1-8 alkyl or heteroaryl-C 1-8 alkyl, wherein aryl-C 1-8 alkyl is optionally substituted on aryl with one, two, three, four or five substituents each selected from hydroxy, C 1-8 alkyl, C 1-8 alkoxy, amino, C 1-8 alkyl-amino or C 1-8 alkoxycarbonyl, and wherein heterocyclyl-C 1-8 alkyl is optionally substituted on heterocyclyl with one, two, three or four substituents each selected from hydroxy, C 1-8 alkyl, C 1-8 alkoxy, amino, C 1-8 alkyl-amino or C 1-8 alkoxycarbonyl; R 2 is selected from hydrogen, C 1-8 alkyl or C 1-8 alkoxy; and R 3 , R 4 , R 5 , R 6 and R 7 is each selected from hydrogen, halogen, hydroxy, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, F—C 1-8 alkyl, F—C 1-8 alkoxy, cyano-C 1-8 alkyl, C 3-12 cycloalkyl, aryl, aryloxy, aryl-C 1-8 alkyl, aryl-C 1-8 alkoxy, heteroaryl, heteroaryloxy, heteroaryl-C 1-8 alkoxy, benzofused-heterocyclyl or heterocyclyl, wherein aryl, aryloxy, aryl-C 1-8 alkyl and aryl-C 1-8 alkoxy is each optionally substituted on aryl with one, two, three, four or five substituents each selected from cyano, halogen, C 1-8 alkyl, C 1-8 alkoxy, or C 1-8 alkoxycarbonyl, wherein benzofused-heterocyclyl is optionally substituted on the heterocyclyl portion with one or two oxo substituents, and wherein heteroaryl, and heteroaryloxy is each optionally substituted on heteroaryl with one, two, three, four or five substituents each selected from C 1-8 alkyl or C 1-8 acyl; comprising the steps of: Step 1. reacting a Compound 1a** (wherein Ra represents a halogen leaving group), a Compound A1 in an aqueous solvent and a catalytic amount of acid to provide a Compound A2 acid salt: Step 2. reacting the Compound A2 acid salt with a Compound A3 bis-acid salt (wherein the acid of the bis-acid salt is HRa) and a base to provide a Compound A4 acid salt, representative of a compound of Formula (I):