Patent ID: 8293750

Claim:
A method for treating mild to severe pain in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I wherein R 1 is selected from the group consisting of i) phenyl optionally substituted with one to two substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, chloro, and fluoro; ii) pyridinyl optionally substituted with one substituent selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, fluoro, chloro, and cyano; and iii) pyrimidin-5-yl; or, R 1 is optionally methoxy-methyl when Y is ethynyl; Y is ethynyl or a bond; R 2 is phenyl, benzofuranyl, 2,3-dihydrobenzofuranyl, benzo[1,3]dioxol-5-yl, indolyl, or pyridinyl optionally substituted with methyl; wherein phenyl is optionally substituted with one to two substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, fluoro, chloro, cyano, cyanomethyl, difluoromethoxy, trifluoromethoxy, and hydroxy; or R 2 is phenyl substituted with one C 1-4 alkylcarbonylamino or 1H-imidazol-1-yl substituent; X is O or CH 2 ; L is absent and R 3 is 4-amino-cyclohexyl; or, L is methylene and R 3 is selected from the group consisting of i) pyrrolidin-2-yl; ii) 1-amino-eth-1-yl; and iii) 1-amino-cyclopent-1-yl; or, R 3 is cyclized with L and the nitrogen atom to which L is attached to form piperazinyl optionally substituted with 4-C 1-4 alkyl; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.