Patent ID: 8524710

Claim:
A compound of formula (I) wherein R 1 is selected from the group consisting of hydrogen, alkyl, morpholinyl, haloalkylamino, alkyloxadiazolyl, hydroxyl, halopyrrolidinyl, azetidinyl, alkylamino, amino, cyanoalkylamino, halophenylalkylamino and cyanocycloalkylamino; R 2 , R 3 , R 4 , R 5 and R 6 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkyloxy, halogen, hydroxyl, cyanopyrazinyloxy, pyrazolyl, alkylpyrazolyl, imidazolyl, benzoimidazolyl, 6-oxo-6H-pyridazinyl, alkyl-6-oxo-6H-pyridazinyl, piperazinyl, N-alkylpiperazinyl, piperidinyl, difluoropyrrolidinyl, phenylimidazolyl, oxo-pyrrolidinyl, oxo-oxazolidinyl, morpholinyl, oxo-morpholinyl, oxo-pyridinyl, 2-oxo-2H-pyrazinyl, difluoropiperidinyl, haloalkylpiperidinyl, piperidinylalkoxy, oxetanyloxy, alkylpyrazolyl, halopyridinyl, alkylpyridinyl, cycloalkyl, cycloalkylalkyl, halophenyl, alkylcarbonylaminocycloalkylalkyl, haloalkylpiperazinyl, alkylamino, alkoxyalkylpiperazinyl, cycloalkylpiperazinyl, hexahydropyrrolo[1,2-a]pyrazinyl, 5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl, alkylimidazolyl, azetidinyl, cycloalkylpiperazinyl, alkylimidazolyl, alkoxyalkoxy, imidazo[4,5-c]pyridinyl, alkylpiperazinyl, hexahydro-pyrrolo[1,2-a]pyrazinyl, haloazetidinyl, pyrimindinyl and alkenyloxy; A 1 is —CH 2 —, carbonyl, —C(O)O— or absent; A 2 is nitrogen or CR 7 ; A 3 is nitrogen or CR 8 ; A 4 is nitrogen or CR 9 ; R 7 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halogen, hydroxyl, haloalkylaminocarbonyl; halophenylalkylaminocarbonyl, phenylcycloalkylaminocarbonyl, haloalkylphenylalkylaminocarbonyl, halophenylcycloalkylaminocarbonyl and halophenylcycloalkylalkylaminocarbonyl; R 8 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halogen and hydroxyl; or R 7 and R 8 together with the carbon atom to which they are attached form cycloalkyl or substituted pyrrolidine, wherein substituted pyrrolidine is pyrrolidine N-substituted with haloalkyl or formyl; R 9 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halogen and nitro; or R 8 and R 9 together with the carbon atom to which they are attached form cycloalkyl; or a pharmaceutically acceptable salt thereof.