Patent ID: 7521464

Claim:
A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: A is —C(═O)Z—; Z is selected from —CH 2 —, —CH(OH)—, —CH(NH 2 )—, —CH(CH 2 (CH))—, —CH(CH(C 1 -C 4 alkyl)(OH))—, and —CH(C(C 1 -C 4 alkyl)(C 1 -C 4 alkyl)(OH))—; R 1 is selected from C 3 -C 8 cycloalkyl, (C 4 -C 8 )cycloalkenyl, (C 5 -C 11 )bi- or tricycloalkyl, (C 7 -C 11 )bi- or tricycloalkenyl, and (C 6 -C 14 )aryl wherein each said cycloalkyl, cycloalkenyl, bi- or tricycloalkyl, bi- or tricycloalkenyl, and aryl is optionally substituted with from one to three substituents R 1b ; R 1b is in each instance independently selected from —Cl, —F, —Br, —I, —CN, and —NO 2 ; R 2 is —H or —C 1 -C 4 alkyl; R 3 is selected from C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, and —C 2 -C 6 alkynyl; R 4 is —H or C 1 -C 4 alkyl; R 6 is selected from —H, —C 1 -C 20 alkyl, —Cl, —F, —Br, —I, —CN, and —CF 3 ; R 7 is —(C zero -C 4 alkylene)-((C 6 -C 14 )aryl) or —(C zero -C 4 alkylene)-((5-15 membered) heteroaryl); wherein each R 7 is optionally substituted with from one to three substituents independently selected from —OH, —C 1 -C 6 alkyl, —C 1 -C 6 alkoxy, —Cl, —F, —Br, —I, —CN, and —NO 2 ; and R 8 is —H or —C 1 -C 4 alkyl.