Patent ID: 7456304

Claim:
A method for improving a conversion rate of oil soluble unsaturated lipid into water-soluble unsaturated lipid comprising: (1-1) dissolving an oil soluble unsaturated lipid in a pyridine; (1-2) adding a thionyl chloride by split injections to the resulting solution from step (1-1) to form an unsaturated lipid-chloride derivative; (1-3) adding the unsaturated lipid-chloride derivative found in step (1-2) to a solution containing dehydrated ethanol and an amino acid to form an amino acid-unsaturated lipid complex in the presence of a pyridine and a thionyl chloride as a catalyst; (1-4) removing the ethanol from the resulting solution formed in step (1-3) by vacuum drying; and (1-5) dissolving a water-soluble unsaturated lipid complex resulting from step (1-4) in water and collecting the water-soluble unsaturated lipid complex using a lyophilizer.