Patent ID: 8580962

Claim:
A compound of Formula I wherein: X is oxygen or sulfur; R 1 is carbon, nitrogen, oxygen or sulfur; R 1a is CH, CH 2 , N, or NH; R 2 is a bond, a CH group or a CH 2 group; R 3 is an alkyl group, an optionally substituted mono-, bi- or tricyclic C 1 -C 13 heterocyclic group containing 1 to 5 heteroatoms selected from N, O, and S; an optionally substituted mono-, bi- or tricyclic C 6 -C 14 aryl group, an optionally substituted C 3 -C 6 cycloalkyl group, or an optionally substituted C 3 -C 6 cycloalkenyl group; R 4 is absent is hydrogen, or is an optionally substituted mono- or bicyclic C 1 -C 9 heterocyclic group containing from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, an optionally substituted mono-, bi- or tricyclic C 6 -C 14 aryl group, an optionally substituted alkyl group, hydroxy, alkoxy, thiol, thioalkyl, amino, N-alkylamino, or N,N-dialkylamino or a halogen atom; R 5 is absent is hydrogen, hydroxyl, thiol, amino, or is optionally substituted alkyl, alkoxy, thioalkyl, alkylamino, dialkylamino, cyano, aminocarbonyl, alkylaminocarbonyl, arylcarbonyl, dialkylaminocarbonyl, N-alkoxy-N-alkylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocyclylcarbonyl, heteroarylcarbonyl, or heterocyclylaminocarbonyl, or a halogen atom; or when R 1 is a carbon atom, R4 and R5 are joined together to form an optionally substituted methylene group, a keto group, an oxime each one optionally substituted with alkyl, cycloalkyl, halogen or a heterocyclic group; or when R 1 is a carbon atom, R 4 and R 5 are each carbon, oxygen, nitrogen, or sulfur linked to each other through an optionally substituted C 1 -C 3 alkylene group; m is 1-2; n is 1-2; o is 0-1; and is a single or double bond; is an optionally substituted phenyl group which is optionally present when m is 1, n is 1 or 2, and o is 1; or enantiomers, diastereomers, or N-oxides thereof; or pharmaceutically acceptable salts thereof.