Patent ID: 8268781

Claim:
Peptide derivatives of exendin-4, wherein their C-terminus is modified by an amine and wherein their N-terminus binds to the GLP-1 receptor, of the formula exendin-4 (1-39)-A, wherein exendin 4 (1-39) corresponds to a sequence identity of over 90% to the amino acid sequence of (SEQ ID NO 3) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys- 1 2 3 4 5 6 7 8 9 10 11 12 Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu- 13 14 15 16 17 18 19 20 21 22 23 24 Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro- 25 26 27 28 29 30 31 32 33 34 35 36 Pro-Pro-Ser-NH 2 ; 37 38 39 with A being an attachment group, which is located at the C-terminus and represents a lysine, and wherein a chelator is coupled with the attachment group A for the labeling with radionuclides.