Patent ID: 8318783

Claim:
A compound represented by Formula I, its individual enantiomers, individual diastereoisomers, individual tautomers or a pharmaceutically acceptable salt thereof wherein: R is H, C 1-10 alkyl, C 3-10 cycloalkyl, —OR 6 , NR 7 R 8 , halogen, nitrile, nitrogen dioxide, C(O)R 9 , aryl or heterocycle; R 1 is H, C 1-10 alkyl, C 3-10 cycloalkyl, —OR 10 , NR 11 R 12 , halogen, nitrile, nitrogen dioxide, C(O)R 13 , aryl or heterocycle; R 2 is H, C 1-10 alkyl, halogen, aryl or heterocycle; R 3 is C 1-10 alkyl, C 3-10 cycloalkyl, —OR 14 ,NR 15 R 16 , halogen, nitrile, nitrogen dioxide, C(O)R 17 , aryl or heterocycle; R 4 is C 1-10 alkyl, C 3-10 cycloalkyl, —OR 18 ,NR 19 R 20 , halogen, nitrile, nitrogen dioxide, C(O)R 21 , aryl or heterocycle; R 5 is C 1-10 alkyl, C 3-10 cycloalkyl, —OR 22 , NR 23 R 24 , halogen, nitrile, nitrogen dioxide, C(O)R 25 , aryl or heterocycle; a is 0, 1, 2 or 3; b is 0, 1, 2 or 3; c is 0, 1, 2 or 3; R 6 is H, C 3-10 cycloalkyl or C 1-10 alkyl; R 7 is H or C 1-10 alkyl; R 8 is H or C 1-10 alkyl; R 9 is H, C 3-10 cycloalkyl, —OH, —OC 3-10 cycloalkyl, —OC 1-10 alkyl or C 1-10 alkyl; R 10 is H, C 3-10 cycloalkyl or C 1-10 alkyl; R 11 is H or C 1-10 alkyl; R 12 is H or C 1-10 alkyl; R 13 is H, C 3-10 cycloalkyl, —OH, —OC 3-10 cycloalkyl, —OC 1-10 alkyl or C 1-10 alkyl; R 14 is H, C 3-10 cycloalkyl or C 1-10 alkyl; R 15 is H or C 1-10 alkyl; R 16 is H or C 1-10 alkyl; R 17 is H, C 3-10 cycloalkyl, —OH, —OC 3-10 cycloalkyl, —OC 1-10 alkyl or C 1-10 alkyl; R 18 is H, C 3-10 cycloalkyl or C 1-10 alkyl; R 19 is H or C 1-10 alkyl; R 20 is H or C 1-10 alkyl; R 21 is H, C 3-10 cycloalkyl, —OH, —OC 3-10 cycloalkyl, —OC 1-10 alkyl or C 1-10 alkyl; R 22 is H, C 3-10 cycloalkyl or C 1-10 alkyl; R 23 is H or C 1-10 alkyl; R 24 is H or C 1-10 alkyl; and R 25 is H, C 3-10 cycloalkyl, —OH, —OC 3-10 cycloalkyl, —OC 1-10 alkyl or C 1-10 alkyl.