Patent ID: 7678789

Claim:
A compound of formula (I): or a tautomer, stereoisomer, or N-oxide thereof, or a pharmacologically acceptable salt of any of the foregoing, wherein the compound of formula (I) has anti-apoptotic activity, and wherein the dotted lines represent single or double bonds, and wherein the compound of formula (I) is chosen from the compounds listed below: R1 R2 R3 R4 CH 3 CH 3 2-pyridyl — CH 3 CH 3 2-F-phenyl — CH 3 CH 3 2-CH 3 -phenyl — CH 3 CH 3 2-CF 3 -phenyl — CH 3 CH 3 2-CH 3 CH 2 -phenyl — CH 3 CH 3 2-(i-Pr)-phenyl — CH 3 CH 3 2-CH 3 O-phenyl — CH 3 CH 3 2-CH 3 S-phenyl — CH 3 CH 3 2-benzyl-phenyl — CH 3 CH 3 2,6-Cl 2 -phenyl — CH 3 CH 3 2,6-(CH 3 ) 2 -phenyl — CH 3 CH 3 3-Cl-phenyl — CH 3 CH 3 3-CH 3 -phenyl — CH 3 CH 3 3-NO 2 -phenyl — CH 3 CH 3 4-(n-Bu)-phenyl — —(CH 2 ) 4 — 2-CH 3 -phenyl — —(CH 2 ) 5 — 2-CH 3 -phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 2-F-phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 2-CH 3 -phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 2-CF 3 -phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 2-CH 3 CH 2 -phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 2-CH 3 O-phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 2-CH 3 S-phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — 3-CH 3 -phenyl — —(CH 2 ) 2 O(CH 2 ) 2 — — —CH 2 —CH(CH 3 )OCH(CH 3 )—CH 2 — 2-F-phenyl — —CH 2 —CH(CH 3 )OCH(CH 3 )—CH 2 — 2-CH 3 O-phenyl — —CH 2 —CH(CH 3 )OCH(CH 3 )—CH 2 — 2-CH 3 CH 2 -phenyl — —(CH 2 ) 2 S(CH 2 ) 2 — 2-F-phenyl — —(CH 2 ) 2 S(CH 2 ) 2 — 2-CH 3 CH 2 -phenyl — —(CH 2 ) 2 N(CH 3 )(CH 2 ) 2 — 2-CH 3 -phenyl — CH 3 — Cl CH 3 CH 3 — CH 3 CH 3 CH 3 — 2-(i-Pr)-phenyl CH 3 CH 3 — 2-CH 3 O-phenyl CH 3 CH 3 — 2,6-Cl 2 -phenyl CH 3 CH 3 — 3-F-phenyl CH 3 CH 3 — 4-F-phenyl CH 3 .