Patent ID: 7022681

Claim:
A compound of the formula: wherein: R 1 is optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R 2 is hydrogen, halo, trifluoromethyl, or cyano; R 3 is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl, R 4 and R 5 are independently hydrogen or optionally substituted acyl; X is a covalent bond or lower alkylene optionally substituted by cycloalkyl; X 1 is a covalent bond or alkylene; Y is a covalent bond or lower alkylene optionally substituted by hydroxy or cycloalkyl; and Z is —C≡C—, —R 6 C═CR 7 —, or —CHR 6 CHR 7 —, in which R 6 and R 7 at each occurrence are hydrogen or lower alkyl.