Patent ID: 7544708

Claim:
A compounds having the structure of Formula I: and its pharmaceutically acceptable salt, pharmaceutically acceptable enantiomer, diastereomer, or N-oxides wherein Ar represents an aryl ring which may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl (C 1 -C 4 ) or -aryl amino, amino carbonyl, or N-lower alkyl (C 1 -C 4 ) or -aryl amino carbonyl; R 1 represents a hydrogen, hydroxy, hydroxy methyl, substituted or unsubstituted amino, alkoxy, carbamoyl or halogen; R 2 represents alkyl, C 3 -C 7 cycloalkyl ring, a C 3 -C 7 cyclo alkenyl ring, an aryl, heterocyclic or a heteroaryl ring having 1 to 2 hetero atoms; the aryl, heteroaryl, heterocyclic or a cycloalkyl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl (C 1 -C 4 ) or -aryl amino, amino carbonyl, or N-lower alkyl (C 1 -C 4 ) or -aryl amino carbonyl; W represents (CH 2 ) p , wherein p represents 0 to 1; X represents no atom; Y represents (CH 2 )q wherein q represents 0; Z represents oxygen, sulphur, or NR 10 , wherein R 10 represents hydrogen or C 1-6 alkyl; Q represents —(CH 2 ) n —, wherein n represents 0 to 4, CHR 8 , wherein R 8 represents H, OH, C 1-6 , alkyl, C 1-6 alkenyl, or C 1-6 alkoxy, or Q represents CH 2 CHR 9 , wherein R 9 represents H, OH, lower alkyl (C 1 -C 4 ) or lower alkoxy (C 1 -C 4 ); and R 6 and R 7 are independently selected from H, CH 3 , COOH, CONH 2 , NH 2 , and CH 2 NH 2 .