Patent ID: 7235657

Claim:
A compound of formula X: wherein R1 is (C1-C6)alkyl, optionally substituted by (C3-C8)cycloalkyl, phenyl, naphthyl, a 5 or 6-membered heterocycloalkyl, or a 5- or 6-membered heteroaryl, wherein each of said (C1-C6)alkyl, (C3-C8)cycloalkyl, phenyl, naphthyl, a 5 or 6-membered heterocycloalkyl, or 5- or 6-membered heteroaryl are optionally substituted by one to three moieties independently selected from the group consisting of hydroxy, halo, —CN, (C1-C6)alkyl, —(C1-C6)alkyl-OH, (C1-C6)alkyl-NH(C═O)—, NH2(C═O)—, (C1-C6)alkoxy, and (C3-C8)cycloalkyl; R 2 is hydrogen, halo, —CN, or (C 1 -C 6 )alkyl, wherein said (C 1 -C 6 )alkyl is optionally substituted by one to three moieties, independently selected from the group consisting of halo, hydroxy, amino, —CN, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, —CF 3 , CF 3 O—, (C 1 -C 6 )alkyl-NH—, [(C 1 -C 6 )alkyl] 2 —N—, (C 1 -C 6 )alkyl-S—, (C 1 -C 6 )alkyl-(S═O)—, (C 1 -C 6 )alkyl-(SO 2 )—, (C 1 -C 6 )alkyl-O—(C═O)—, formyl, (C 1 -C 6 )alkyl-(C═O)—, and (C 3 -C 6 )cycloalkyl; wherein R 4 is independently selected from the group consisting of hydrogen, halo, hydroxy, —CN, HO—(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl optionally substituted with one to three fluoro, (C 1 -C 6 )alkoxy optionally substituted with one to three fluoro, —CO 2 H, (C 1 -C 6 )alkyl-O—(C═O)—, R 5 R 6 N(O 2 S)—, (C 1 -C 6 )alkyl-(O 2 S)—NH—, (C 1 -C 6 )alkyl-O 2 S—[(C 1 -C 6 )alkyl-N]—, R 5 R 6 N(C═O)—, R 5 R 6 N(CH 2 ) m —, phenyl, naphthyl, (C 3 -C 8 )cycloalkyl, a 5- or 6-membered heteroaryl, a 5 or 6-membered heterocycloalkyl, phenyl-O—, naphthyl-O—, (C 3 -C 8 )cycloalkyl-O—, a 5- or 6-membered heteroaryloxy and 5 or 6-membered heterocycloalkyl-O—; PG 2 is selected from the group consisting of: trimethylsilyl, triethylsilyl, tri-isopropylsilyl, dimethylisopropylsilyl, diethylisopropylsilyl diethylisopropylsilyl, dimethylthexylsilyl, tert-butyldimethylsilyl, di-tert-butylmethylsilyl, tert-butyldiphenylsilyl, tribenzylsilyl, tri-p-xylylsilyl, triphenylsilyl, diphenylmethylsilyl, and tert-butyl(methoxy)diphenylsilyl; R 5 and R 6 are each independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, —(C 2 -C 6 )alkyl-OH, and (C 3 -C 8 )cycloalkyl, or R 5 and R 6 may optionally be taken together with the nitrogen atom to which they are attached to form a 5 or 6-membered heterocycloalkyl; R 10 and R 11 are independently selected from the group consisting of: (C 1 -C 6 )alkyl optionally substituted with one to three halos, hydroxy, —CN, (C 1 -C 6 )alkoxy-, ((C 1 -C 6 )alkyl) 2 —N—, (C 1 -C 6 )alkyl-(C═O)—, (C 3 -C 8 )cycloalkyl-(C═O)—, a 5 or 6-membered heterocycloalkyl-(C═O)—, phenyl-(C═O)—, naphthyl-(C═O)—, a 5- or 6-membered heteroaryl-(C═O)—, (C 1 -C 6 )alkyl-(C═O)O—, (C 1 -C 6 )alkyl-O(C═O)—, (C 3 -C 8 )cycloalkyl, phenyl, naphthyl, a 5 or 6-membered heterocycloalkyl, and 5- or 6-membered heteroaryl; and m is one or two.