Patent ID: 7618962

Claim:
A compound of formula I: wherein: R is hydrogen or is selected from the group consisting of (C 1-5 )alkyl, halo(C 1-8 )alkyl, (C 3-8 )cycloalkyl, (C 3-8 )cycloalkyl(C 1-8 )alkyl-, (C 3-5 )alkenyl and (C 3-5 )alkynyl, each substituted or unsubstituted; one of R 1 and R 2 is selected from the group consisting of cyclopropyl, cyclopropylmethyl, cyclobutyl, hydroxycyclobutyl, trihalomethylcyclobutyl and cyclopentyl; the other of R 1 and R 2 is selected from the group consisting of hydrogen, substituted or unsubstituted (C 1-8 )alkyl, halo(C 1-8 )alkyl, (C 3-8 )alkenyl, (C 3-8 )alkenyl(C 1-8 )alkyl, (C 3-8 )alkynyl, (C 3-8 )alkynyl(C 1-8 )alkyl, (C 1-8 )alkoxy, (C 3-8 )cycloalkyl, (C 3-8 )cycloalkyl(C 1-8 )alkyl-, (C 4-10 )heterocyclyl, (C 4-10 )heterocyclyl(C 1-8 )alkyl-, (C 6-10 )aryl, (C 6-10 )aryloxy, (C 6-10 )aryl(C 1-8 )alkyl-, (C 5-10 )heteroaryl and (C 5-10 )heteroaryl(C 1-8 )alkyl-; L and L 1 are each independently a linker selected from the group consisting of substituted or unsubstituted —NR o —C(O)—, —NCH 3 —C(O)—, —NR o —S(O)—, —NCH 3 —S(O)—, —NR o —S(O) 2 —, —NCH 3 —S(O) 2 —, —C(O)NR o —, —C(O)NCH 3 —, —NR o C(O)CH 2 —, —NR o C(O)CH 2 CH 2 —, —C(O)NR o CH 2 —, —C(O)NR o CH 2 CH 2 —, —C(O)CH 2 NR o —, —C(O)CH 2 CH 2 NR o —, —CH 2 NR o C(O)—, —CH 2 CH 2 NR o C(O)—, —CH 2 C(O)NR o —, —CH 2 CH 2 C(O)NR o —, —NR o CH 2 C(O)— and —NR o CH 2 CH 2 C(O)—, wherein each R o is independently hydrogen or substituted or unsubstituted (C 1-4 )alkyl, (C 1-4 )alkylC(O)—, (C 6-10 )arylC(O)— and (C 5-10 ) heteroarylC(O)—, Z is a substituted or unsubstituted heteroaryl ring selected from the group consisting of imidazolyl, triazolyl, pyrrolyl, pyrazolyl and tetrazolyl; Z 1 is a 5-14 member substituted or unsubstituted heteroaryl ring; where m is 0, 1 or 2; n is 1 or 2; or a pharmaceutically acceptable salt thereof.