Patent ID: 8906869

Claim:
A method for treating ovarian cancer in a mammal comprising: (i) obtaining a biological sample from the tumor or cancer; (ii) determining whether the tumor or cancer overexpresses an Akt kinase, and (iii) if the tumor or cancer overexpresses Akt kinase, administering to said mammal a dose of 10 mg/m 2 or less of at least one compound of the formula: wherein each R 2′ , R 3′ and R 5′ are independently hydrogen, optionally substituted phosphate or phosphate; acyl; alkyl; amide, sulfonate ester; sulfonyl; methanesulfonyl; benzylsulfonyl, wherein the phenyl group is optionally substituted with one or more substituents; optionally substituted arylsulfonyl; a lipid, phospholipid; an amino acid; a carbohydrate; a peptide; or cholesterol; or other pharmaceutically acceptable leaving group that, in vivo, provides a compound wherein R 2′ , R 3′ or R 5′ is independently H or mono-, di- or tri-phosphate; wherein R x and R y are independently hydrogen, optionally substituted phosphate; acyl; amide, alkyl; aromatic, polyoxyalkylene; polyethyleneglycol optionally substituted arylsulfonyl, a lipid, phospholipid; an amino acid; a carbohydrate; a peptide; or cholesterol; or other pharmaceutically acceptable leaving group; wherein R 1 and R 2 each are independently H, optionally substituted straight chained, branched or cyclic alkyl, alkenyl, or alkynyl, CO-alkyl, CO-alkenyl, CO-alkynyl, CO-aryl or heteroaryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, sulfonyl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl.