Patent ID: 7495006

Claim:
A cyclobutyl nucleoside of the formula (I)-(IV): or a pharmaceutically acceptable salt, ester, salt of an ester, prodrug, salt of a prodrug, enantiomer, diastereomer, or tautomer thereof, wherein; Base is a purine or pyrimidine base; Z is independently phosphate selected from the group consisting of monophosphate, diphosphate, triphosphate and a stabilized phosphate prodrug, P(O)Z′Z″, CH 2 P(O)Z′Z″, alkyl, sulfonate ester, or sulfonyl Z′ and Z″ each independently is OH, OAlkyl, OAryl, alkyl, aryl, SH, SAlkyl, SAryl, NH 2 , mono or di-alkylamino, mono- or di-arylamino, or a residue of an amino acid; A is O, S, or CH 2 ; or alternatively A can be a covalent bond when Z is P(O)Z′Z″ or CH 2 P(O)Z′Z″; R 1 , R 2 , and R 3 are independently hydrogen, lower alkyl, halogenated lower alkyl, CF 3 , 2-Br-ethyl, lower alkenyl, halogenated lower alkenyl, Br-vinyl, lower alkynyl, halogenated lower alkynyl, halo, cyano, azido, NO 2 , NH 2 , —NH(lower alkyl), NH(acyl), N(lower alkyl) 2 , —N(acyl) 2 , OZ, O(lower alkyl), O(alkenyl), C(O)O(alkyl), C(O)O(lower alkyl); or alternatively, R 1 and R 2 together are ═CH 2 or ═CHY; or alternatively R 1 and R 2 can come together to form a three-membered carbocyclic or heterocyclic ring, such as an epoxide ring; such that if R 1 is H, then R 2 is not CH 2 OH, and if R 2 is H, then R 1 is not CH 2 OH; X is CH 2 , CHY, or S; and Y is independently H, methyl, halogenated methyl, CF 3 , halogen, N 3 , cyano, or NO 2 .