Patent ID: 7572808

Claim:
A compound according to Formula I or a pharmaceutically acceptable salt or a stereoisomer thereof wherein R 1 is selected from the group consisting of hydrogen, cyano, halogen, phenyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, imidazolyl, quinolinyl, methylendioxyphenyl, benzopyrazinyl, alkyl, -and OR 6 , any of which may be optionally substituted with 1 to 3 R 11 ; R 2 is selected from the group consisting of phenyl and pyridyl, either of which may be optionally substituted with 1 to 3 R 11 ; R 3 is selected from the group consisting of hydrogen, halogen, cyano, alkyl, alkoxy, phenyl and pyridyl, where the phenyl and pyridyl may be optionally substituted with 1 to 3 R 11 ; R 4 is selected from the group consisting of hydrogen, alkyl, methoxy, phenoxy and phenylamino, R 5 is alkyl which may be optionally substituted with 1 to 3 R 10 , provided that R 5 as substituted is not optionally substituted 2-[4-(indol-3-yl)piperidin-1-yl]ethyl, 2-[4-(indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl, 3-[4-(indol-3-yl)piperidin-1-yl]propyl, 3-[4-(indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]propyl, 4-[4-(indol-3-yl)piperidin-1-yl]butyl, or 4-[4-(indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]butyl; R 6 is selected from the group consisting of H, alkyl, phenyl and pyridyl; R 7 , R 8 , and R 9 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, and alkynyl; R 10 in each instance is independently selected from the group consisting of phenyl, pyridyl, pyridine-N-oxide, benzoxazolyl, and OR 6 , any of which may be optionally substituted with 1 to 3 R 11 ; R 11 in each instance is independently selected from the group consisting of phenyl, isoxazolyl, pyrazolyl, alkyl, OR 6 , NR 7 SO 2 R 6 , SO 2 R 6 , COR 7 , CO 2 R 6 , CONR 7 R 8 , halogen, cyano, hydroxyl, any of which, except for halogen and cyano, may be optionally substituted with 1 to 3 R 12 ; and R 12 in each instance is independently selected from the group consisting of alkyl, alkenyl, alkynyl, heterocyclyl, OR 6 , OCOR 7 , OCONR 7 R 8 , OSO 2 NR 7 R 8 , NR 7 R 8 , NR 7 COR 8 , NR 7 CO 2 R 6 , NR 7 CONR 8 R 9 , NR 7 SO 2 R 6 , NR 7 SO 3 R 6 , NR 7 SO 2 NR 8 R 9 , SR 6 , SO 2 R 6 , SO 2 NR 7 R 8 , COR 7 , CO 2 R 6 , CONR 7 R 8 , halogen, cyano, hydroxyl, carboxyl, and the divalent groups oxo (═O) and oximato (═NOR 7 ); provided that R 1 and R 3 are not both H.