Patent ID: 7399776

Claim:
A compound of the formula: wherein X is —CH 2 —, —C 2 H 4 —, or —C 3 H 6 —; Y is aryl, heteroaryl, C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl, C 3 -C 8 heterocycloalkyl, or C 5 -C 8 heterocycloalkenyl; each of Z 1 and Z 2 , independently, is —CH 2 —, —C 2 H 4 —, or —C 3 H 6 —; R 1 is aryl or heteroaryl; R 2 is -A 1 -B 1 -D 1 -E 1 ; R 3 is -A 2 -B 2 -D 2 -E 2 ; and R 4 is -A 3 -B 3 -D 3 -E 3 or, together with R 3 , is C 4 -C 20 heterocycloalkyl; in which A 1 is —CH 2 —, —C 2 H 4 —, —C 3 H 6 —, —C 4 H 8 —, or —C 5 H 10 —B 1 is —NR—; D 1 is —CH 2 —, —C 2 H 4 —, or —C 3 H 6 —; and E 1 is aryl or heteroaryl; A 2 deleted; B 2 is deleted; D 2 is deleted; and E 2 is H, C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl, C 3 -C 8 heterocycloalkyl, C 5 -C 8 heterocycloalkenyl, aryl, or heteroaryl; A 3 is —CH 2 —, —C 2 H 4 —, —C 3 H 6 —, —C 4 H 8 —, —C 5 H 10 —, or deleted; B 3 is deleted; D 3 is deleted; and E 3 is C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl, C 3 -C 8 heterocycloalkyl, C 5 -C 8 heterocycloalkenyl, aryl, or heteroaryl; and each R, independently, being H or C 1 -C 10 alkyl.