Patent ID: 8236801

Claim:
A compound of formula (I) wherein the stereogenic centers are in Absolute (1R,3S,4S)-configuration wherein A represents aryl or heterocyclyl, wherein the aryl or heterocyclyl is unsubstituted or independently mono- or di-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-6 )alkinyl, (C 1-4 )alkoxy, NR 2 R 3 , halogen, (C 1-4 )alkoxy-(C 1-4 )alkoxy, and unsubstituted or independently mono- or di-substituted phenyl or pyridyl, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, trifluoromethyl, trifluoromethoxy, fluorine and chlorine; B represents an aryl- or heterocyclyl-group, wherein the aryl or heterocyclyl is unsubstituted or independently mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, trifluoromethyl, trifluoromethoxy, —NR 4 R 5 , —NHSO 2 —(C 1-4 )alkyl, —N(R 4 )C(O)R 5 and halogen; or B represents a benzo[1,3]dioxolyl group; n represents the integer 0 or 1; R 1 represents heterocyclyl, wherein the heterocyclyl is unsubstituted or mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, trifluoromethyl and —NR 4 R 5 ; or R 1 represents a 1H-indenyl, a 2,3-dihydro-benzofuranyl-, a benzo[1,3]dioxolyl-, a 2,3-dihydro-benzo [1,4]dioxinyl-, a 4H-benzo[1,3]dioxinyl-, a 2H-chromenyl-, a chromanyl-, a 2,3-dihydro-thieno[3,4-b][1,4]dioxinyl-, a 3,4-dihydro-2H-benzo[1,4]oxazinyl- or a 2,3,6,7-tetrahydro-benzo[1,2-b; 4,5-b′]difuranyl-group; wherein said groups are unsubstituted, mono- or di-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy and halogen; R 2 represents hydrogen or (C 1-4 )alkyl; R 3 represents hydrogen or (C 1-4 )alkyl; or R 2 and R 3 together with the nitrogen to which they are attached to form a pyrrolidine ring; R 4 represents hydrogen or (C 1-4 )alkyl; and R 5 represents hydrogen or (C 1-4 )alkyl; or a pharmaceutically acceptable salt of such a compound.