Patent ID: 7192582

Claim:
An isolated human monoclonal antibody, or antigen binding portion thereof, selected from the group consisting of: (a) an antibody, or antigen binding portion thereof, comprising (i) a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising amino acid residues 30–35, amino acid residues 50–66, and amino acid residues 99–108 of SEQ ID NO:2, respectively; and (ii) a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising amino acid residues 24–34, amino acid residues 50–56, and amino acid residues of 89–97 of SEQ ID NO:4, respectively, wherein the antibody binds to human CD89; and (b) an antibody, or antigen binding portion thereof, comprising (i) a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising amino acid residues 31–35, amino acid residues 50–66, and amino acid residues 99–108 of SEQ ID NO:6, respectively; and (ii) a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising amino acid residues 24–35, amino acid residues 51–57, and amino acid residues 90–99 of SEQ ID NO:8, respectively, wherein the antibody binds to human CD89.