Patent ID: 8741883

Claim:
A method of inhibiting binding between A-beta fibrils and amyloid-binding proteins, said method comprising contacting A-beta fibrils with a compound of formula I: wherein R 1 -R 8 are selected from the group consisting of hydrogen, deuterium, tritium, fluoride, chloride, bromide, iodide, hydroxide, amino, methylamino, dimethylamino, trimethylammonium, methyl, ethyl, methoxy, ethoxy, fluoromethyl, difluoromethyl and trifluoromethyl, wherein at least one of R 5 -R 8 and one of R 1 -R 4 is H; and P is selected from the group consisting of wherein m is an integer between 1 and 20; n is 0, 1, or 2; q is an integer between 1 and 20; R 9 -R 16 are selected from the group consisting of hydrogen, deuterium, tritium, fluoride, chloride, bromide, iodide, hydroxide, amino, methylamino, dimethylamino, trimethylammonium, methyl, ethyl, methoxy, ethoxy, fluoromethyl, difluoromethyl and trifluoromethyl, wherein at least one of R 9 -R 12 and one of R 13 -R 16 is H; X is hydrogen, methyl, or ethyl, thereby inhibiting binding between A-beta fibrils and amyloid binding proteins.