Patent ID: 8784843

Claim:
A stabilizer for a freeze-dried live attenuated canine distemper (CDV) and canine parainfluenza type 2 (cPi2) immunogenic composition comprising at least one reducing monosaccharide and at least one acid antioxidant compound, wherein the at least one acid antioxidant compound consists of aspartic acid; and wherein the at least one reducing monosaccharide consists of glucose, galactose, fructose, mannose, sorbose, or combinations thereof; wherein the at least one reducing monosaccharide is at a concentration from 20% to 50% w/w and the at least one acid antioxidant is at a concentration from 1.5% to 6% w/w; and wherein the stabilizer further consists of: (a) a bulking agent selected from dextran, maltodextrin, polyvinylpymolidone, hydroxyethyl starch, and combinations thereof, or (b) a sugar alcohol selected from sorbitol, mannitol, xylitol, maltitol and combinations thereof, or (c) a combination thereof; and wherein the stabilizer is capable of reducing the amount of CDV and cPi2 titer lost during the freezing process by at least 0.5 logs.