Patent ID: 8598317

Claim:
A mutein of human tear lipocalin, wherein the mutein comprises at least two amino acid mutations of wild type mature human tear lipocalin (SEQ ID NO: 1), and where said mutations are at two positions selected from the group consisting of positions 24-36, 53-66, 79-84, and 102-110 of said wild type mature human tear lipocalin, wherein said mutations includes at least one substitution selected from the group consisting of: Arg60→Lys, His; Gln62→Lys, Arg, His, Ile, Thr; and Gln64→His, Aro, Trp, Tyr and at least one substitution selected from Glu104→Ser, Ala, Leu, Trp, Tyr, Ile, and wherein the mutein binds to the extracellular region of the T-cell coreceptor CD4 with detectable affinity.