Patent ID: 8617886

Claim:
A composition formulated for oral consumption, comprising: (a) at least about 500 mg of leucine and/or at least about 200 mg of one or more leucine metabolites, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and (b) at least about 10 mg of a sirtuin pathway activator; wherein the components of (a) and (b) are present in an amount that is effective in increasing sirtuin pathway output by at least about 1 fold as compared to that of component (a) or (b) when being used alone, wherein the increased sirtuin-pathway output is evidenced by an increase in a physiological effect selected from the group consisting of fatty acid oxidation, mitochondrial biogenesis, glucose uptake, palmitate uptake, oxygen consumption, weight loss, visceral adipose tissue loss, insulin sensitivity, an inflammation marker level, vasodilatation, and body temperature, when (i) media from myotubes or adipocytes treated with the composition is administered to the other of the myotubes or adipocytes, (ii) the composition is administered to myotubes or adipocytes, or (iii) the composition is administered to a subject, wherein the composition is substantially free of the individual amino acids alanine, glutamic acid, glycine, and proline, and wherein the molar ratio of component (a) to (b) in said composition is greater than about 20.