Patent ID: 8463365

Claim:
A method for the treatment of diseased tissue in a subject in need thereof comprising: (a) illuminating an in vivo exposed body cavity, integument, or organ of a subject containing diseased tissue with light having at least one excitation wavelength in the range from 350 nm to 510 nm; (b) directly viewing fluorescence emanating from a fluorescent targeting construct bound to diseased tissue in the illuminated body cavity, integument, or organ, the construct comprising: a fluorophore-tagged tumor-specific antibody and a therapeutic isotope molecule; or a fluorophore-tagged tumor avid moiety and a therapeutic isotope molecule, wherein the fluorophore-tagged tumor-specific antibody or fluorophore-tagged tumor avid moiety is responsive to the excitation wavelength administered to the subject and has specifically bound to or been taken up by the diseased tissue in the exposed body cavity, integument, or organ; (c) identifying diseased tissue in the subject by direct visualization of the fluorescence provided by the fluorescent targeting construct without the aid of a capture device; (d) removing diseased tissue identified by the direct visualization; and (e) allowing the therapeutic isotope molecule to remain in contact with residual diseased tissue not removed in step (d).