Patent ID: 8597590

Claim:
A system for distribution of a biological sample, the system comprising: a substrate, wherein the substrate comprises a main fluid supply channel connected to and fluidly communicating with a plurality of sample introduction channels, each sample introduction channel being connected to and fluidly communicating with a sample chamber, each sample chamber being connected to and fluidly communicating with a venting channel; a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate; and a sealing instrument, operable to individually isolate each sample chamber from each other so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber, wherein the sealing instrument comprises a plurality of protrusions selected from the group consisting of thermal transfer dies, substantially arc-shaped pins, circumferential disks and circular pins, each of the plurality of protrusions aligned to intersect and deform the sample introduction or venting channel of each sample chamber, wherein the substrate is constructed of detection-compatible and assay-compatible materials.