Patent ID: 8865682

Claim:
A method of treating a disease selected from the group consisting of diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, arthritis, restenosis, hepatic cirrhosis, atherosclerosis, glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, transplant rejection glomerulopathies, psoriasis, diabetes mellitus, wound healing, and inflammation, the method comprising the step of administering to a subject in need thereof a therapeutically effective amount of at least one compound of formula IA: or a pharmaceutically acceptable salt thereof; wherein: X is O; Y is O; the ring system represented by A in formula V, below, is a 6 membered aryl group, wherein said aryl group is: and wherein the ring system represented by B in formula VI is a five membered unsaturated heterocyclic ring having the formula: wherein Z is [C(R 2 ) 2 ] c ; wherein R 1 is —X′-D wherein X′ is selected from the group consisting of and D is a 6 membered carbocyclic aryl ring substituted with one or more substituents selected from the group consisting of (CR 3a R 4a ) d′ C(O)OR 2 , (CR 3a R 4a ) d′ C(O)N(R 2 ) 2 , and NR 2 C(O)(CR 3a R 4a ) d′ R 3a ; wherein each R 2 independently is selected from the group consisting of hydrogen, and C 1 -C 8 alkyl; R in variable R a is (CR 3 R 4 ) d″ R 8 wherein (CR 3 R 4 ) d″ is morpholine, and R 8 is selected from the group consisting of H, F, C 1 -C 4 alkyl and hydroxy; R 3a and R 4a are independently H or C 1 -C 4 alkyl; R 6a is hydrogen; R 7 is selected from the group consisting of hydrogen, and C 1 -C 8 alkyl; a in variable R a is 1; b in the variable —(C═X) b — is 0; b in variable R 1 b is 1; c in the variable [C(R 2 ) 2 ] c is an integer of from 1 to 2; d is 0; d′ is 0; and f in —S(O) f — in the definition of X′ above is 0.