Patent ID: 8242277

Claim:
A process for the preparation of a 1,2,3,4-tetrahydroisoquinoline corresponding to Formula 700, the process comprising treating a 3,4-dihydroisoquinoline corresponding to Formula 600 with an asymmetric catalyst in the presence of silver tetrafluoroborate, and a hydrogen source wherein R 1 and R 7 are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or —OR 111 ; R 2 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 211 ; R 3 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or —OR 311 ; R 4 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 411 ; R 5 and R 6 are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or —OR 511 ; R 12 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 121 ; R 13 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or —OR 511 ; R 17 is hydrogen, or acyl; R 111 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; R 211 is hydrogen, hydrocarbyl, —(O)R 212 , —(O)NHR 213 , or —SO 2 R 214 , R 212 , R 213 , and R 214 are independently hydrocarbyl or substituted hydrocarbyl; R 311 is hydrogen, hydrocarbyl, —(O)R 312 , —(O)NHR 313 , or —SO 2 R 314 , R 312 , R 313 , and R 314 are independently hydrocarbyl or substituted hydrocarbyl; R 411 is hydrogen, hydrocarbyl, —(O)R 412 , —(O)NHR 413 , or —SO 2 R 414 , R 412 , R 413 , and R 414 are independently hydrocarbyl or substituted hydrocarbyl; R 511 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; and R 121 is hydrogen, hydrocarbyl, or substituted hydrocarbyl.