Patent ID: 8298564

Claim:
A method comprising: incorporating a first therapeutic agent in a first polymeric material, wherein the first therapeutic agent is selected from minocycline and rifampin, wherein the only therapeutic agent incorporated into the first polymeric material is the minocycline or the rifampin; disposing the first polymeric material on or about an implantable medical device; sterilizing the first polymeric material and the implantable medical device by a first sterilization method, wherein if the first therapeutic agent is rifampin, the first sterilization method is a method other than ethylene oxide sterilization, and wherein if the first therapeutic agent is minocycline, the first sterilization method comprises ethylene oxide sterilization; incorporating a second therapeutic material in a second polymeric material, wherein if the first therapeutic agent is minocycline, then the second therapeutic agent is rifampin, wherein if the first therapeutic agent is rifampin, then the second therapeutic agent is minocycline wherein the only therapeutic agent incorporated into the second polymeric material is the minocycline or the rifampin; disposing the second polymeric material on or about the sterilized first polymeric material and implantable medical device; and sterilizing the second polymeric material by a second sterilization method, wherein if the second therapeutic agent is rifampin, the second sterilization method is a method other than ethylene oxide sterilization, and wherein if the second therapeutic agent is minocycline, the second sterilization method comprises ethylene oxide sterilization.