Patent ID: 7279280

Claim:
A method for identifying nucleic acid mutations comprising; obtaining a sample of target nucleic acid oligomers comprising at least one target sequence; where the target sequence is also known to exist in mutated form; dividing the sample into at least two parts; loading the parts onto at least two portions of binding medium; where each part is loaded onto a separate portion of binding medium; where the binding medium comprises probe nucleic acid oligomers bound to a solid support; where a first portion of binding medium comprises probe oligomers that are complementary to the at least one target sequence; where a second portion of binding medium comprises probe oligomers that are complementary to a mutated form of the at least one target sequence; where the rates of hybridization and dissociation of the target oligomers and the probe oligomers is about the same; flowing the oligomer-containing sample parts through the binding medium portions; detecting oligomer peaks in the fluid exiting from each of the at least two portions of binding medium; analyzing the oligomer peak data from the at least two portions of binding medium to identify the target nucleic acid oligomer mutations.