Patent ID: 6864253

Claim:
A compound of the formula (I): wherein R 1 is independently selected from the group consisting of halogen, nitro, hydroxy, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, —NH 2 , —NHR A , —N(R A ) 2 , —O—R A , —C(O)NH 2 , —C(O)NHR A , —C(O)N(R A ) 2 , —NC(O)—R A , —SO 2 NHR A , —SO 2 N(R A ) 2 , phenyl (optionally substituted with 1 to 3 R B ) and heteroaryl (optionally substituted with 1 to 3 R B ); where each R A is independently is independently selected from the group consisting of C 1 -C 8 alkyl, aryl (optionally substituted with 1 to 3 R B ), C 1 -C 8 aralkyl (optionally substituted with 1 to 3 R B ) and heteroaryl (optionally substituted with 1 to 3 R B ); where each R B is independently selected from the group consisting of halogen, hydroxy, nitro, cyano, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, C 1 -C 8 alkoxycarbonyl, carboxyC 1 -C 8 alkyl, C 1 -C 8 alkylsulfonyl, trifluoromethyl, trifluoromethoxy, amino, acetylamino, di(C 1 -C 8 alkyl)amino, di(C 1 -C 8 alkyl)aminoC 1 -C 8 alkoxy, di(C 1 -C 8 alkyl)aminoacetylC 1 -C 8 alkyl, di(C 1 -C 8 alkyl)aminoacetylamino, carboxyC 1 -C 8 alkylcarbonylamino, hydroxyC 1 -C 8 alkylamino, NHR A, N(R A ) 2 and heterocycloalkylC 1 -C 8 alkoxy; n is an integer from 0 to 4; X is selected from the group consisting of O and S; R 2 is selected from the group consisting of C 5 -C 10 alkyl (optionally substituted with 1 to 3 R C ), aryl (optionally substituted with 1 to 3 R B ), heteroaryl (optionally substituted with 1 to 3 R B ) and heterocycloalkyl (optionally substituted with 1 to 3 R B ); where each R C is independently selected from the group consisting of halogen, hydroxy, nitro, NH 2 , NHR A and N(R A ) 2 ; Z is CH 2 ; R 4 is selected from the group consisting of hydrogen, hydroxy, carboxy, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxylcarbonyl, di-(C 1 -C 8 alkyl)aminoalkoxycarbonyl, di(C 1 -C 8 alkyl)aminoC 1 -C 8 alkylaminocarbonyl, and —COR F ; where R F is selected from the group consisting of C 1 C 8 alkyl, NH 2 , NHR A , NR A 2 , —C 1 -C 8 alkyl-NH 2 , —C 1 -C 8 alkyl-NHR A , —C 1 -C 8 alkyl-NR A 2 and —NH—C 1 -C 8 alkyl-NR A 2 ; a is an integer from 0 to 1; Y is selected from the group consisting of CH 2 , C(O), C(O)O, C(O)—NH and SO 2 ; is selected from the group consisting of naphthyl, heteroaryl and heterocycloalkyl; m is an integer from 0 to 2; R 3 is independently selected from the group consisting of halogen, nitro, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, trifluoromethyl, trifluoromethoxy, phenyl (optionally substituted with 1 to 3 R B ), phenylsulfonyl, naphthyl, C 1 -C 8 aralkyl, heteroaryl (optionally substituted with 1 to 3 R B ), NH 2 , NHR A and N(R A ) 2 ; provided that when is 2-furyl or 2-thienyl, then in is an integer from 1 to 2; and pharmaceutically acceptable salts thereof.