Patent ID: 8658661

Claim:
A compound of Formula I wherein: R 1 and R 2 are each independently hydrogen, C 1-7 alkyl or C 3-10 carbocycle, with the proviso that both R 1 and R 2 are not hydrogen; R 3 is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, imidazolyl, thienyl, or furanyl, wherein each heteroaryl ring is optionally independently substituted with one to three groups selected from C 1-3 alkyl optionally substituted with one to three halogen atoms, C 1-3 alkoxy, C 1-3 hydroxy, halogen, hydroxy, —O-benzyl, oxo, cyano, amino, —NH—C 3-6 carbocycle, C 1-6 alkylamino and C 1-3 dialkylamino; or R 3 is pyridooxazinyl, dihydro-pyridooxazinyl, dihydro-pyrrolopyridinyl, pyrrolopyridinyl, pyrrolopyrazinyl, wherein each heteroaryl ring is optionally independently substituted with one to three groups selected from C 1-3 alkyl optionally substituted with one to three halogen atoms, C 1-3 alkoxy, C 1-3 hydroxy, halogen, hydroxy, —O-benzyl, oxo, cyano, amino, —NH—C 3-6 carbocycle, C 1-3 alkylamino and C 1-3 dialkylamino; R 4 is hydrogen, C 1-3 alkyl, halogen or nitrile; R 5 is C 1-6 alkyl, C 3-10 carbocycle, 3-11 membered heterocycle, aryl, 5-11 membered heteroaryl, —C(O)—R 6 , hydroxy or —NR 7 R 8 , wherein each R 5 is optionally independently substituted with one to three groups selected from R 9 , R 10 and R 11 ; R 6 is C 3-8 heterocycle or —NH-5-6 membered heterocycle, each optionally independently substituted with one to three groups selected from R 9 , R 10 and R 11 ; R 7 and R 8 are each independently hydrogen, 5-6 membered heterocycle optionally substituted with C 1-6 alkyl, C 3-10 carbocycle optionally substituted with hydroxy or C 1-6 alkyl; R 9 , R 10 and R 11 are independently selected from (a) —H, (b) —OH, (c) halogen, (d) —CN, (e) —CF 3 , (f) C 1-6 alkyl optionally substituted with one to three —OH, —N(R 12 )(R 13 ), 3-6 membered heterocycle, C 1-6 alkoxy, C 1-6 alkoxy-O—C 1-6 alkyl, —CO 2 R 12 , —C(O)N(R 12 )(R 13 ) or —S(O) n C 1-6 alkyl, (g) C 1-6 alkoxy, (h) —N(R 12 )(R 13 ), (i) —S(O) n C 1-6 alkyl, (j) —CO 2 R 12 , (k) —C(O)N(R 12 )(R 13 ), (l) —S(O) 2 N(R 12 )(R 13 ), (m) a 3-10 membered heterocyclic group optionally substituted with one to three C 1-6 alkyl groups, (n′) oxo, (o) —C(O)—C 1-3 alkyl; R 12 and R 13 are each independently selected from —H, —C 1-6 alkyl, C(O)C 1-6 alkyl, and a 3-6 membered heterocyclic group, each of which is optionally independently substituted with one to three C 1-6 alkyl groups, —OH, C 1-6 alkoxy, —C(O)N(R 14 )(R 15 ), —S(O) n C 1-6 alkyl, CN, a 3-6 membered heterocyclic group, —OC 1-6 alkyl, CF 3 , or; R 12 and R 13 taken together with the nitrogen ring to which they are attached form a heterocyclyl ring optionally substituted with one to three —OH, CN, —OC 1-6 alkyl or oxo; R 14 and R 15 are each independently selected from —H and —C 1-6 alkyl; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.