Patent ID: 7576239

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein; R 1 is selected from: (1) aryl, (2) aryl-C 1-4 alkyl, (3) heteroaryl, (4) heteroaryl-C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a , and each aryl and heteroaryl are optionally substituted with one to four substituents independently selected from R b ; R 2 is benzyl, unsubstituted or substituted with halogen, cyano, trifluoromethyl or methoxy; R 3 is selected from: (1) hydrogen, and (2) C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a ; R 4 is selected from: (1) hydrogen, and (2) C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a ; R 5 is selected from: (1) C 1-8 alkyl substituted with —OR d or NR c R d , (2) C 2-8 alkenyl substituted with OR d or NR c R d , and (3) phenyl-C 1-8 alkyl wherein phenyl is substituted with one to three R b substitutents; R 6 is selected from: (1) C 1-4 alkyl, (2) C 2-4 alkenyl, (3) C 2-4 alkynyl, (4) halogen, and (5) —CN, wherein alkyl, alkenyl, and alkynyl are optionally substituted with one to four substituents independently selected from R a ; each R a is independently selected from: (1) —OR d , (2) —NR c S(O) m R d , (3) halogen, (4) —S(O) m R d , (5) —S(O) m NR c R d , (6) —NR c R d , (7) —C(O)R d , (8) —CO 2 R d , (9) —CN, (10) —C(O)NR c R d , (11) —NR c C(O)R d , (12) —NR c C(O)OR d , (13) —NR c C(O)NR c R d , (14) —CF 3 , (15) —OCF 3 , and (16) cycloheteroalkyl; each R b is independently selected from: (1) R a , (2) C 1-10 alkyl, (3) oxo, (4) aryl, (5) arylC 1-4 alkyl, (6) heteroaryl, and (7) heteroarylC 1-4 alkyl; R c and R d are independently selected from: (1) hydrogen, (2) C 1-10 alkyl, (3) C 2-10 alkenyl, (4) cycloalkyl, (5) cycloalkyl-C 1-10 alkyl; (6) cycloheteroalkyl, (7) cycloheteroalkyl-C 1-10 alkyl; (8) aryl, (9) heteroaryl, (10) aryl-C 1-10 alkyl, and (11) heteroaryl-C 1-10 alkyl, or R c and R d together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N—R g , each R c and R d may be unsubstituted or substituted with one to three substituents selected from R h ; each R g is independently selected from: C 1-10 alkyl, and —C(O)R c ; each R h is independently selected from: (1) halogen, (2) C 1-10 alkyl, (3) —O C 1-4 alkyl, (4) —S (O) m C 1-4 alkyl, (5) —CN, (6) —CF 3 , and (7) —OCF 3 ; and m is selected from 0, 1 and 2.