Patent ID: 8476253

Claim:
A compound of formula (I) or a pharmacologically acceptable salt thereof: wherein R 1 represents a hydrogen atom, a C 1 -C 6 alkyl group, a (C 3 -C 6 cycloalkyl)methyl group, a C 2 -C 7 alkoxycarbonyl group or a benzyl group, R 2 represents a hydrogen atom, a C 1 -C 6 alkyl group or a C 2 -C 7 alkoxycarbonyl group, R 3 represents a phenyl group optionally substituted with 1 to 5 groups each independently selected from Substituent Group A or a heterocyclic group optionally substituted with 1 to 3 groups each independently selected from Substituent Group A, R 4 represents a phenyl group optionally substituted with 1 to 5 groups each independently selected from Substituent Group A or a heterocyclic group optionally substituted with 1 to 3 groups each independently selected from Substituent Group A, L 1 represents a C 1 -C 10 alkylene group or a C 1 -C 10 alkylene group in which one methylene group is replaced by an oxygen atom and when R 1 is a C 1 -C 6 alkyl group, any carbon atom of R 1 optionally binds to any carbon atom of L 1 , L 2 represents a carbonyl group, a hydroxymethylene group, an ester group, a group represented by a formula —N(R 5 )—, a group represented by a formula —N(R 5 )—C(═O)—, a group represented by a formula —C(═O)—N(R 5 )—, a group represented by a formula —N(R 5 )—C(═O)—O— or a group represented by a formula —O—C(═O)—N(R 5 ) wherein R 5 represents a hydrogen atom, a C 1 -C 6 alkyl group, a C 3 -C 6 cycloalkyl group or a C 1 -C 6 alkoxy group, E represents a phenylene group optionally substituted with 1 to 4 groups each independently selected from Substituent Group A, or a heteroarylene group optionally substituted with 1 or 2 groups each independently selected from Substituent Group A, wherein E binds to a methylene group on either side via a carbon atom thereof and when R 1 or R 5 is a C 1 -C 6 alkyl group, any carbon atom of R 1 or R 5 optionally binds to any carbon atom of E, m represents an integer of 1 to 4, n represents an integer of 0 to 4, p represents an integer of 0 to 2, q represents an integer of 1 to 10, r represents 1 or 2, s represents 0 or 1, and Substituent Group A represents a group consisting of a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a hydroxy group, a C 1 -C 6 alkoxy group, a C 1 -C 6 halogenated alkoxy group, a cyano group, a carboxyl group, a C 2 -C 7 alkylcarbonyloxy group, a C 2 -C 7 alkoxycarbonyloxy group, a carbamoyl group, a nitro group, and an amino group.