Patent ID: 8795662

Claim:
A method of detecting or diagnosing pancreatic cancer comprising: a) administering to an individual a humanized anti-MUC5ac monoclonal antibody or antigen-binding fragment thereof that binds to the same epitope as or competes for binding to MUC5ac with an antibody that comprises the light chain variable region CDR sequences CDR1 (SASSSVSSSYLY, SEQ ID NO:1); CDR2 (STSNLAS, SEQ ID NO:2); and CDR3 (HQWNRYPYT, SEQ ID NO:3); and the heavy chain variable region CDR sequences CDR1 (SYVLH, SEQ ID NO:4); CDR2 (YINPYNDGTQYNEKFKG, SEQ ID NO:5) and CDR3 (GFGGSYGFAY, SEQ ID NO:6), wherein the anti-MUC5ac antibody is labeled with at least one diagnostic agent; and b) detecting the antibody or fragment thereof bound to pancreatic cancer cells.