Patent ID: 7220859

Claim:
A compound or a pharmaceutically acceptable salt or a stereoisomer according to Formula I: wherein, A is selected from the group consisting of CO and SO 2 ; B is selected from the group consisting of a direct bond, oxygen, NR 8 and alkyl; R 1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl and CF 3 ; R 2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, COOR 7 and CONR 7 R 7a ; R 3 and R 3a are hydrogen or R 3 and R 3a taken together form a double bond with oxygen; R 4 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; R 7 and R 7a are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 7 and R 7a taken together can form cycloalkyl or heterocyclyl; R 8 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 4 and R 8 taken together can form cycloalkyl or heterocyclyl; n is an integer of 0 or 1.