Patent ID: 7678374

Claim:
A fusion polypeptide comprising a polypeptide of interest (POI) fused to a particle-associating portion of a large envelope polypeptide (L) of an avian hepadnavirus wherein the POI is not a pre-S region of an avian hepadnavirus and is located N-terminally to said particle-associating portion of the L polypeptide, and wherein the particle-associating portion consists of a fragment of the L polypeptide, wherein said fragment is (i) the S domain, (ii) the S domain minus the TM1 domain, or (iii) a portion of the L polypeptide which is downstream of TM1 and comprises at least TM2, the 5′ cysteine loop between TM1 and TM2, and the sequence downstream of TM2.