Patent ID: 8741281

Claim:
A composition comprising: a) adipose tissue; b) a silk fibroin material; and c) a therapeutically effective amount of a compound of the structure of formula I wherein each dashed line represents the presence or absence of a bond; R 1 , R 2 and R 3 are each independently selected from H or C 1-6 alkyl; R 6 is CO 2 H, CO 2 R 7 , CON(R 7 ) 2 , CONHCH 2 CH 2 OH, CON(CH 2 CH 2 OH) 2 , CH 2 OR 7 , P(O)(OR 7 ) 2 , R 7 is independently H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; X and Y are each independently selected from H, OH, ═O, Cl, Br, I, or CF 3 ; Z 1 and Z 2 are each independently selected from CH or N; W 1 and W 2 are each independently selected from CH, CH 2 , optionally substituted aryl, or optionally substituted heteroaryl; m is 0, 1, 2, 3, 4, 5 or 6; o is 0, 1, 2, 3, or 4; p is 0 or 1; and V is methyl, optionally substituted aryl, or optionally substituted heteroaryl; wherein, when V is methyl, Z 1 or Z 2 is N; a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof.