Patent ID: 8871511

Claim:
A method of treating a cardiovascular disorder in a subject in need thereof, comprising: administering to said subject a mesothelial composition comprising acellular bioremodelable mesothelial tissue, said mesothelial tissue comprising endogenous proteoglycans, transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), said mesothelial tissue further comprising an exogenously added statin, wherein, when said mesothelial composition is administered to damaged cardiovascular tissue, said statin interacts with said mesothelial tissue, wherein myofibroblast and stem cell migration is induced, differentiation of said stem cells into cardiomyocytes is induced, RhoA activation is restricted and matrix metalloprotinase (MMP) production is reduced in said cardiovascular tissue, wherein said mesothelial composition induces neovascularization and bioremodeling of said cardiovascular tissue; providing a ventricular assist device; and simultaneously providing ventricular assistance to said subject by administering said ventricular assist device and said mesothelial composition to damaged cardiovascular tissue associated with said cardiovascular disorder.