Patent ID: 8841418

Claim:
An antibody linked to a cytotoxic agent, wherein the antibody specifically binds the extracellular domain of human T-cell Immunoglobulin Mucin (TIM) 3, wherein said binding results in internalization into a TIM3-expressing cell, and wherein the antibody is selected from the group consisting of (i) an antibody having light chain complementarity determining region (CDR) sequences of SEQ ID NOs:8-10 and heavy chain CDR sequences of SEQ ID NOs:3-5; (ii) an antibody having light chain CDR sequences of SEQ ID NOs:18-20 and heavy chain CDR sequences of SEQ ID NOs:13-15; (iii) an antibody having light chain CDR sequences of SEQ ID NOs:28-30 and heavy chain CDR sequences of SEQ ID NOs:23-25; (iv) an antibody having light chain CDR sequences of SEQ ID NOs:108-110 and heavy chain CDR sequences of SEQ ID NOs:103-105; and (v) an antibody having light chain CDR sequences of SEQ ID NOs:118-120 and heavy chain CDR sequences of SEQ ID NOs: 113-115.