Patent ID: 8685383

Claim:
A polymeric scaffold of Formula (Ia) useful to conjugate with a protein based recognition-molecule (PBRM) that has a molecular weight of greater than 40 kDa: wherein: the scaffold comprises poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) having a molecular weight ranging from 2 kDa to 40 kDa; each occurrence of D is independently a therapeutic agent having a molecular weight of â‰¦5 kDa; L D1 is a carbonyl-containing moiety; each occurrence of is independently a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; and the between L D1 and D denotes direct or indirect attachment of D to L D1 ; each occurrence of is independently a second linker not yet connected to the PBRM, in which L P2 is a moiety containing a functional group that is yet to form a covalent bond with a functional group of the PBRM, and the between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1 , and each occurrence of the second linker is distinct from each occurrence of the first linker; m is an integer from 1 to 300, m 1 is an integer from 1 to 140, m 2 is an integer from 1 to 40, m 3 is an integer from 1 to 18, and the sum of m, m 1 , m 2 and m 3 ranges from 15 to about 300.