Patent ID: 7771726

Claim:
A method for augmenting the immunogenicity of an antigen in a mammal, comprising immunizing the mammal with a composition comprising (i) the antigen and (ii) an adjuvant in an amount effective to augment the immunogenicity of said antigen, wherein the adjuvant comprises a compound of Formula I: wherein X is O or NH; R 1 is selected from the group consisting of —(CH 2 ) 11 CH 3 , —(CH 2 ) 12 CH 3 , —(CH 2 ) 13 CH 3 , —(CH 2 ) 9 CH(CH 3 ) 2 , —(CH 2 ) 10 CH(CH 3 ) 2 , —(CH 2 ) 11 CH(CH 3 ) 2 and (CH 2 ) 11 CH(CH 3 )—C 2 H 5 ; R 3 is OH or a monosaccharide and R 4 is hydrogen, or R 3 is hydrogen and R 4 is OH or a monosaccharide; R 5 is hydrogen or a monosaccharide; Q 1 is optionally present and is a C 1-10 straight or branched chain alkylene, alkenylene, or alkynylene; X′ is optionally present and is O, S or NR 8 ; Q 2 is optionally present and is a C 1-10 straight or branched chain alkylene, alkenylene or alkynylene; X″ is optionally present and is O, S or NR 8 ; Q 3 is a straight or branched chain C 1-10 alkyl, alkenyl or alkynyl, or is hydrogen, wherein each Q 1 , Q 2 or Q 3 is optionally substituted with hydroxyl, halogen, cyano, nitro, SO 2 , NHR 8 , or C(═O)—R 9 ; and wherein R 8 is hydrogen, C 1-5 alkyl, C 1-5 alkoxy, halogen, cyano, nitro, SO 2 or C(═O)—R 9 ; R 9 is hydrogen, C 1-5 alkyl, C 1-5 alkoxy or NHR 10 ; R 10 is hydrogen, C 1-5 alkyl or C 1-5 alkoxy; a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and wherein the effective amount of the adjuvant is in the range of 10-100 μg per kg of body weight.