Patent ID: 8718950

Claim:
A non-transitory processor-readable medium storing code representing instructions to be executed by a processor, the code comprising code to cause the processor to: receive a plurality of variants identified by a comparison of a test DNA sequence with a reference DNA sequence; associate at least one variant from the plurality of variants with at least one annotation from a plurality of annotations including at least one of: (i) reported to cause a disorder and recognized to cause a disorder, (ii) unreported but expected to cause a disorder, (iii) unreported and of the type that might be causative of a disorder, (iv) unreported and unlikely to cause a disorder, (v) reported and recognized neutral variant, or (vi) unknown or not expected to be causative of disease, but associated with clinical presentation; filter, based on the plurality of annotations, the plurality of variants to identify a set of variants from the plurality of variants, each variant from the set of variants being associated with at least one common annotation from the plurality of annotations; and present the set of variants such that the set of variants can be used to render a clinical diagnosis.