Patent ID: 7504233

Claim:
A method of determining a rate of in vivo metabolism of one or more sugars or fatty acids in an individual, said method comprising: (a) administering a known quantity of 2 H-labeled sugars or 2 H-labeled fatty acids to an individual for a sufficient time for said 2 H-labeled sugars or 2 H-labeled fatty acids to be metabolized in said individual to produce 2 H-labeled water; (b) obtaining one or more bodily tissues or fluids at one or more times from said individual, wherein said one or more bodily tissues or fluids comprise a portion of said 2 H-labeled water; (c) determining a quantity of 2 H present in said portion of said 2 H-labeled water to quantify an amount of 2 H released into body water; and (d) calculating a ratio of said amount of 2 H released into body water to said known amount of 2 H administered to determine said rate of in vivo metabolism of said one or more of sugars or fatty acids in said individual.