Patent ID: 8889411

Claim:
A method of treating an individual in need of granulocytes comprising: contacting mammalian CD34 + or CD133 + hematopoietic stem cells with 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione or 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, under conditions under which said hematopoietic stem cells differentiate, wherein said contacting increases the number of CFU-GM and decreases the number of BFU-E differentiated from said stem cells relative to the numbers of CFU-GM and BFU-E differentiated from said hematopoietic stem cells not contacted with said compound; and administering said differentiated cells to said individual.