Patent ID: 7556925

Claim:
A fibronectin type III (Fn3) polypeptide monobody derived from the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 3, the polypeptide monobody comprising: at least two adjacent Fn3 β-strand domain sequences selected from the group of A-G with a loop region sequence linked between adjacent β-strand domain sequences, the loop region sequence being selected from the group of loops AB, BC, CD, DE, EF, and FG; and optionally, an N-terminal tail of at least about 2 to about 25 amino acids, a C-terminal tail of at least about 2 to about 25 amino acids, or both; wherein: at least one loop region sequence, selected from the group of AB, BC, CD, DE, and FG loop region sequences, comprises a modified amino acid sequence which varies from a corresponding loop region sequence present in SEQ ID NO:2 or 3 by deletion of up to all but one amino acid residue, insertion of two to about 25 amino acid residues, or replacement of two to substantially all amino acid residues, one modified amino acid sequence comprises RGDWXE (residues 2-7 of SEQ ID No: 26), and wherein the polypeptide monobody binds selectively to αvβ3 integrin.