Patent ID: 7025964

Claim:
A method for treating Japanese cedar pollen allergy in a subject in need thereof, the method comprising: (a) identifying an HLA class II molecule expressed by the subject; (b) selecting an antigenic peptide derived from Japanese cedar pollen allergen Cry j 1 or Cry j 2, wherein the antigenic peptide binds to HLA class II molecule and wherein: (1) when the HLA class II molecule identified in step (a) is DQA1*0102-DQB1*0602, the antigenic peptide is selected from the group consisting of SEQ ID NO: 1, 5, 7, 9, 10, 21, 23, and 142; (2) when the HLA class II molecule identified in step (a) is DPA1*0101-DPB1*0501, the antigenic peptide is selected from the group consisting of SEQ ID NO: 2, 8, and 15; (3) when the HLA class II molecule identified in step (a) is DPA1*0101-DPB1*0201, the antigenic peptide is SEQ ID NO: 17; (4) when the HLA class II molecule identified in step (a) is DPA1*0202-DPB1*0501, the antigenic peptide is SEQ ID NO: 22; (5) when the HLA class II molecule identified in step (a) is DRB5*0101, the antigenic peptide is selected from the group consisting of SEQ ID NO: 3, 4, 14, and 19; (6) when the HLA class II molecule identified in step (a) is DRB1*0901, the antigenic peptide is selected from the group consisting of SEQ ID NO: 6, 7, 12, 16, and 20; (7) when the HLA class II molecule identified in step (a) is DRB4*0101, the antigenic peptide is selected from the group consisting of SEQ ID NO: 7, 12, and 18; and (8) when the HLA class II molecule identified in step (a) is DRB1*0501, the antigenic peptide is selected from the group consisting of SEQ ID NO: 13 and 19; and (c) administering the selected antigenic peptide to the subject.