Patent ID: 7576102

Claim:
A compound of formula: wherein Ar is selected from the group consisting of phenyl and phenyl substituted with from one to three substituents independently selected from the group consisting of halogen, loweralkyl, loweracyl, loweralkoxy, fluoroloweralkyl, fluoroloweralkoxy, formyl, cyano, benzyl, benzyloxy, phenyl, substituted phenyl, heteroaryl, heterocyclylalkyl and nitro; X is selected from the group consisting of O, CH 2 , CF 2 , C═O, and CR 1a R 1b ; R 1a and R 1b are selected from the group consisting of H and lower alkyl, or R 1a and R 1b taken together may form a 3-6 membered ring, which may optionally contain a heteroatom chosen from O, S, SO, SO 2 , and NR 10 ; R 10 is selected separately in each occurrence from the group consisting of H and lower alkyl; m is zero, 1 or 2; n is 1 or 2; p is 1; Y is selected from H,H; O; and H,R 3 ; R 3 is lower alkyl; Z is (CH 2 ) 1-10 ; in which one or two (CH 2 ) may optionally be replaced by a —O—, —NR 10 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)—, provided that said —O—, —NR 10 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)— are not at the point of attachment to nitrogen and are separated by at least one —(CH 2 ) 2 —; W is carboxyl or carboxamido; and R 4 is selected from the group consisting of H and lower alkyl.