Patent ID: 8138340

Claim:
A compound selected from the group consisting of bicyclononene compounds of the formula (I) X represents —NH— or —N(L); W represents a five-membered heteroaryl containing a nitrogen and a sulfur, wherein said heteroaryl radical is optionally mono-substituted by C 1-7 -alkyl; V represents —CH 2 CH 2 —O—, —CH 2 CH 2 CH 2 —O—, —O—CH 2 CH 2 —O—, —O—CH 2 CH 2 CH 2 —O—, —CH 2 —O—CH 2 CH 2 —O—, —O—CH 2 CH 2 —O—CH 2 —, or —O—CH 2 CH 2 CH 2 —O—CH 2 —; U represents unsubstituted aryl; mono-, di-, tri- or tetra-substituted aryl, wherein the substituents are independently selected from C 1-7 -alkyl, C 1-7 -alkoxy, —CF 3 , —OCF 3 , halogen and hydroxy-C 1-7 -alkyl; or five-membered heteroaryl containing two heteroatoms independently selected from nitrogen, oxygen and sulfur, wherein said heteroaryl radical is optionally mono-, di- or tri-substituted, wherein the substitutents are independently selected from C 1-7 -alkyl, C 1-7 -alkoxy, —CF 3 , —OCF 3 and halogen; T represents —CONR 1 — or —CH 2 CONR 1 —; Q represents methylene; M represents unsubstituted aryl; mono- di- or tri-substituted aryl, wherein the substituents are independently selected from C 1-7 -alkyl, C 1-7 -alkoxy, —OCF 3 , —CF 3 , hydroxy-C 1-7 -alkyl, and halogen; or mono- or di-substituted pyridinyl, wherein the substituents are independently selected from halogen, C 1-7 -alkyl, —OCF 3 , —CF 3 and C 1-7 -alkoxy; with the proviso, that the halogen substituents are not in 2- or 6-position of the pyridinyl ring; L represents —R 3 , —COR 3 , —COOR 3 , —CONR 2 R 3 , —SO 2 R 3 , or —SO 2 NR 2 R 3 ; R 1 and R 1′ independently represent C 1-7 -alkyl or cycloalkyl; R 2 and R 2′ independently represent hydrogen, C 1-7 -alkyl, C 2-7 -alkenyl, cycloalkyl, or cycloalkyl-C 1-7 -alkyl; R 3 represents C 1-7 -alkyl, cycloalkyl, or cycloalkyl-C 1-7 -alkyl, wherein these groups may be unsubstituted or mono-, di- or tri-substituted, wherein the substituents are independently selected from hydroxy, —NH 2 , —OCOR 2 , —COOR 2 , —SO 3 H, —SO 2 CH 3 , C 1-7 -alkoxy, cyano, —CONR 2 R 2′ , —NH(NH)NH 2 , —NR 1 R 1′ , tetrazolyl, and C 1-7 -alkyl, with the proviso that a carbon atom is attached at the most to one heteroatom in case this carbon atom is sp 3 -hybridized; including its optically pure enantiomers, diastereomers, free base and salt forms.