Patent ID: 8293773

Claim:
A compound of formula I Ar—X—Y—Z formula I and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Ar is in which R 1 and R 2 each independently represent phenyl, thienyl or pyridyl, each substituted by one or more halo; X is —(CH 2 ) b — in which b is 1, 2, 3 or 4; Y is —C(O)— or —S(O 2 )—; and Z is NR 4 R 5; R 4 is H, —(CH 2 ) r (Ph) s , —C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 5-9 aryl, C 4-9 cycloalkyl, carbamoyl, ureido, adamantyl, —CHR 6 R 7 , or C 4-9 heteroaryl or C 3-10 heterocycloalkyl comprising one to three heteroatoms which each independently are N, O, or S, in which R 6 and R 7 each independently are C 1-4 alkyl alcohol, C 1-4 alkyl or benzyl, with a proviso that one of R 4 and R 5 is not H and one of R 6 and R 7 is not H, wherein R 6 and R 7 are unsubstituted or optionally substituted by thiohydroxy, hydroxy, phenyl, nitro, or C 1-4 alkoxy; R 5 is —(CH 2 ) r (Ph) s or C 4-9 cycloalkyl; wherein R 4 , R 5 , are unsubstituted or optionally further substituted by halo, hydroxy, cyano, nitro, thiohydroxy, amino, carbonyl, carbamoyl, sulfamoyl, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 1-4 alkyl alcohol, C 1-4 haloalkyl, C 1-4 haloalkylthio, C 1-4 alkylamino, C 1-4 alkylamido, C 1-4 alkylsulfonyl, C 1-4 haloalkylsulfonyl, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbamoyl, phenyl or benzyl; r is 1, 2, 3, or 4; and s is 1 or 2.