Patent ID: 7659317

Claim:
A method for labeling synthesis of organohalides, comprising: (a) providing a high pressure reaction chamber having a liquid/gas inlet and a gas inlet in a bottom surface thereof, (b) providing a substrate solution to be labeled mixed with a transition metal complex, (c) providing H 2 gas or HOR, with optional water, where R is independently linear or lower cyclic alkyl or aryl, (d) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber via the gas inlet, (e) introducing at high-pressure said H 2 gas or HOR, with optional water, into the reaction chamber via the liquid/gas inlet, (f) introducing at high-pressure said substrate solution mixed with transition metal complex into the reaction chamber via the liquid/gas inlet, (g) waiting a predetermined time while the labeling synthesis occur, and (h) removing the labeled compounds from the reaction chamber, (i) reducing the labeled compounds to alcohol, (j) substituting with a halogen atom to obtain the labeled organohalides.