Patent ID: 7166587

Claim:
A compound of formula wherein R 1 is —(CHR′) q -aryl or —(CHR′) q -heteroaryl, which is unsubstituted or mono, di- or tri-substituted by lower alkyl, lower alkoxy, CF 3 or halogen, wherein heteroaryl is selected from the group consisting of pyridyl, pyrazinyl, pyrimidinyl, triazinyl, thiazolyl, thiophenyl, furyl, pyrazol, pyrrolyl, and imidzaolyl; or is lower alkyl, lower alkenyl, —(CH 2 ) n —Si(CH 3 ) 3 , —(CH 2 ) n —O-lower alkyl, —(CH 2 ) n —S-lower alkyl, —(CH 2 ) q -cycloalkyl, or —(CH 2 ) n —[CH(OH)] m —(CF 2 ) p —CH q F (3-q) , or is —(CH 2 ) n —CR 2 —CF 3 , wherein the two R radicals form together with the carbon atom a cycloalkyl ring; R′ is hydrogen or lower alkyl; n is 1, 2 or 3; m is 0 or 1; p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2 or 3; R 2 is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl, —CH 2 CF 2 CF 3 , CH 2 CF 3 , (CH 2 ) 2 CF 3 , CF 3 , CHF 2 , CH 2 F or is aryl optionally mono, di or tri-substituted by halogen, or is —(CH 2 ) n NR 5 R 6 wherein R 5 and R 6 are each independently selected from hydrogen or lower alkyl; R 4 is one of the following groups wherein R 7 is hydrogen, lower alkyl, —(CH 2 ) n —CF 3 or —(CH 2 ) n -cycloalkyl; R 8 is hydrogen, lower alkyl, —C(O)-phenyl, —C(O)-lower alkyl, —C(O)O—(CH 2 ) n -cycloalkyl, —C(O)O—(CH 2 ) n -lower alkyl, —C(O)NH—(CH 2 ) n -lower alkyl or —C(O)NH—(CH 2 ) n -cycloalkyl; R 9 is hydrogen, lower alkyl, —(CH 2 ) n -cycloalkyl or —(CH 2 ) n —CF 3 ; or a pharmaceutically acceptable salt, optically pure enantiomer, racemate or diastereomeric mixture thereof.