Patent ID: 8318710

Claim:
A method for reducing chronoageing and/or photoageing of the skin by providing at least one skin care benefit selected from reducing wrinkles, fine lines, sagging, loss of elasticity, loss of firmness, dermal thinning, epidermal thinning and age spots; said method comprising administering to an individual a composition comprising (i) an LXR activator other than 25-hydroxycholesterol and (ii) a retinoid selected from retinyl esters of all-trans rentinol, all-trans retinol, all-trans retinal, all-trans retinoic acid and mixtures thereof; wherein the LXR activator comprises a compound of formula (B): wherein; R is a C 1 to C 10 unsubstituted, branched and unsaturated alkyl group, and wherein R 1 ; R 2 , R 4 , R 5 , X, and Y are all hydrogen, wherein the mixture of LXR activator and retinoic acid act synergistically to upregulate CRAB P II expression when tested in vitro in dermal fibroblasts, and wherein the composition is either a topical composition comprising from 0.01% to 10% by weight of the LXR activator and from 0.001 to 10% by weight of the retinoid, the balance comprising at least one dermatologically acceptable carrier; or the composition is a systemic composition comprising from 0.01% to 10% by weight of the LXR activator and from 0.001 to 10% by weight of the retinoid, the balance comprising at least one pharmaceutically acceptable carrier.