Patent ID: 8497263

Claim:
A compound of the formula (I′): wherein Z 1 is hydroxy optionally protected, hydroxyamino optionally protected or amino optionally substituted; Z 2 is ═O or ═N-E wherein E is hydrogen, hydroxy, lower alkyl optionally substituted, lower alkoxy optionally substituted, or amino optionally substituted, or in which R 4 and R 5 are independently hydrogen or lower alkyl, R 6 is hydrogen, lower alkyl optionally substituted or acyl, and r is an integer 0 to 2; A is cycloalkyl, cycloalkenyl, cycloalkenyl or aryl; B is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; R 1a and R 1b are independently halogen, hydroxy, lower alkyl optionally substituted, lower alkenyl optionally substituted, lower alkynyl optionally substituted, lower alkoxy optionally substituted, lower alkylthio optionally substituted, acyl optionally substituted, carboxy, lower alkoxycarbonyl optionally substituted, carbamoyl optionally substituted, lower alkylcarbamoyl optionally substituted, amino optionally substituted, sulfamoyl optionally substituted, cyano or nitro; m and p are independently an integer 0 to 2; R 2 is alkyl optionally substituted, lower alkoxy optionally substituted, lower alkylcarbamoyl optionally substituted, cycloalkyl optionally substituted, cycloalkenyl optionally substituted, aryl optionally substituted or heterocyclyl optionally substituted; and R 3 is hydrogen, lower alkyl optionally substituted, cycloalkyl optionally substituted, cycloalkenyl optionally substituted, aryl optionally substituted or heterocyclyl optionally substituted; provided that a compound wherein all of the following conditions are collectively satisfied is excluded: in which R 4 and R 5 are independently hydrogen or lower alkyl, R 6 is hydrogen or lower alkyl optionally substituted and r is 0; A is phenyl and B is heterocyclyl; R 1a and R 1b are independently halogen, hydroxy, lower alkyl optionally substituted, lower alkenyl optionally substituted, lower alkynyl optionally substituted, lower alkoxy optionally substituted, lower alkylthio optionally substituted, acyl optionally substituted, carboxy, lower alkoxycarbonyl optionally substituted, carbamoyl optionally substituted, lower alkylcarbamoyl optionally substituted, amino optionally substituted, sulfamoyl optionally substituted, cyano or nitro; m and p are independently an integer 0 to 2; R 2 is alkyl optionally substituted; and R 3 is hydrogen or lower alkyl optionally substituted, or a pharmaceutically acceptable salt thereof.