Patent ID: 7807678

Claim:
A peptidomimetic of the formula: wherein X 1 is (CH 2 ) m ; X 2 bearing the R 5 substituent is N and all other X 2 are CH 2 ; R 5 is R 6 is —(CH 2 ) 4 NH 2 , —(CH 2 ) 3 NHC(NH 2 )═NH, —(CH 2 ) 3 NHCOCH 3 , —(CH 2 ) 3 NHCOOCH 3 , —(CH 2 ) 2 NHC(NH 2 )═NH, —(CH 2 ) 2 NHCONH 2 , —(CH 2 ) 4 NHCOH, —(CH 2 ) 4 NHCOCH 3 , —(CH 2 ) 3 NHCONHCH 3 , —(CH 2 ) 3 NHSO 2 NH 2 , —(CH 2 ) 3 NHSO 2 CH 3 , —(CH 2 ) 3 NH 2 , —(CH 2 ) 2 CONH 2 , —(CH 2 ) 3 NH(C═NH)NHMe, —(CH 2 ) 3 NH(C═NH)NHEt, —(CH 2 ) 3 NH(C═NH)NHPr, —(CH 2 ) 3 NH(C═NH)NHPr-i, —(CH 2 ) 3 NH(C═NH)NH 2 , —(CH 2 ) 4 NHCONH 2 , —(CH 2 ) 4 NH(C═NH)NH 2 , R 7 is R 9 -R 8 -; R 8 is an L- or D-configuration of Phe, Phe(2-Cl), Phe(4-Cl), Phe(2,4-diCl), Phe(3,4-diCl), Phe(4-NO 2 ), Phe(4-Me), Phe(4-Phenyl), HPhe, Phg, Trp, NaI 1, NaI 2, Bip, Dip, Bpa, Ser(Bzl), Lys(Z), Lys(Z-2′Br), Lys(Bz), Thr(Bz1), Cys(Bz1), Tyr(BzlCl 2 ), pF-Phe, Phe(4-Br), Phe(4-CF 3 ), Phe(3,4-diF), Phe(4-I) or Phe(3,4-di-OMe); R 9 is optionally not present or is an L- or D-configuration of H is, Ser(Bzl), Tic, heptanoyl-Ser(Bzl), hexanoyl-Ser(Bzl), Hyp(Bzl), 4-phenylPro, 5-phenylPro, Tiq, Atc, Igl, Hyp(O-2-Naphthyl), Hyp(O-Phenyl), 2-Aic, Idc, 1-Aic, NH 2 (CH 2 ) 6 CO—, Benzyl, Beta-homoSer(Bz1), Ser(O-2-Naphthyl), Ser(O-Phenyl), Ser(O-4-Cl-Phenyl), Ser(O-2-Cl-Phenyl), Thr(Bzl), Tic, heptanoyl-Thr(Bzl), hexanoyl-Thr(Bzl), Beta-homoThr(Bzl), Thr(O-2-Naphthyl), Thr(O-Phenyl), Thr(O-4-Cl-Phenyl) or Thr(O-2-Cl-Phenyl); n is 1; and mist.