Patent ID: 8024048

Claim:
A method of treating abnormal tissue growth, comprising: implanting a first electrode at the site of the abnormal tissue growth; implanting a generator that functions as a second electrode at a position at least about 5 cm away from the abnormal tissue growth from the abnormal tissue growth; administering a therapeutic agent having an electrical charge near the second electrode; applying a first form of electrical therapy at a voltage of between about 3V to 5V between the first and second electrodes in which the second electrode is provided with a polarity similar to the charge of the therapeutic agent and the first electrode is provided with a polarity dissimilar to the charge of the therapeutic agent so that the first form of electrical therapy is effective for causing said therapeutic agent to migrate through bodily tissue to the first electrode implanted at the site of the abnormal tissue growth, administering a second form of electrical therapy between the first and second electrodes effective for achieving electroporation of cellular membranes, said second form of electrical therapy being delivered at a voltage between about 200 V and about 1300 V; wherein the first form of electrical therapy is applied for a sufficient amount of time to cause a change in pH of at least about 2 at the site of the abnormal tissue growth.