Patent ID: 8188045

Claim:
A method for inhibiting or reducing blood loss in a patient comprising administering to the patient a non-naturally occurring kallikrein inhibitor polypeptide in combination with an anti-fibrinolytic agent, wherein the kallikrein inhibitor polypeptide comprises the amino acid sequence Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (amino acid residues 3-60 of SEQ ID NO:2), wherein the non-naturally occurring kallikrein inhibitor polypeptide and the anti-fibrinolytic agent are administered in combination with an anticoagulation agent, and wherein the blood loss is perioperative blood loss due to a surgical procedure performed on the patient.