Patent ID: 8435343

Claim:
A bone graft composition comprising a plurality of particles of a cementitious substance and a plurality of particles of a non-cementitious substance, wherein the non-cementitious substance comprises calcium sulfate dihydrate and the cementitious substance comprises calcium sulfate hemihydrate, and wherein the plurality of particles of the non-cementitious substance is characterized by at least two non-overlapping ranges of particle size, the composition being characterized by a particle size distribution according to formula I: T=a 0 S 0 +a 1 S 1 +a 2 S 2 +a 3 S 3 +a 4 S 4 + . . . +a i S i + . . . +a n S n wherein: T is the particle size distribution of the composition; S 0 is the particle size range of the cementitious substance; a 0 is a percentage by weight of the particles of the cementitious substance of the total weight of the composition; i is an integer ranging from 1 to n; n is an integer greater than 2; S 1 , S 2 , S 3 , . . . S i . . . Sn are each a particle size range of the non-cementitious substance; at least two of S 1 , S 2 , S 3 , . . . S i . . . Sn are non-overlapping particle size ranges; a 1 , a 2 , a 3 , . . . a i are each a percentage by weight of the particles of the non-cementitious substance having S 1 , S 2 , S 3 , . . . S i particle size range of the total weight of the composition, wherein: when n=2: S 1 is from 1000 μm to 2000 μm; and S 2 is from 500 μm to 1000 μm, when n=3: S 1 is from 900 μm to 1800 μm; S 2 is from 600 μm to 1200 μm; and S 3 is from 200 μm to 600 μm, and when n=4: S 1 is from 800 μm to 1600 μm; S 2 is from 500 μm to 800 μm; S 3 is from 0 μm to 500 μm; and S 4 is from 0 μm to 100 μm, wherein the cementitious substance and the non-cementitious substance form a biocompatible concrete upon contacting a mixture thereof with an aqueous solution.