Patent ID: 7595401

Claim:
A compound of Formula I wherein: A is a substituted or unsubstituted indanone group; B is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; R1 is chosen from hydro, alkyl, aryl, heteroaryl, amino, and halo; L 1 can be saturated, partially saturated, or unsaturated, and is chosen from —(CH 2 ) n —(CH 2 ) n —, —(CH 2 ) n C(═O)(CH 2 ) n —, —(CH 2 ) n C(═O)(CH 2 ) n —, —(CH 2 ) n NC(═O)O(CH 2 ) n —, —(CH 2 ) n NC(═O)N(CH 2 ) n —, —(CH 2 ) n NC(═S)S(CH 2 ) n —, —(CH 2 ) n OC(═O)S(CH 2 ) n —, —(CH 2 ) n NH(CH 2 ) n —, —(CH 2 ) n O(CH 2 ) n —, —(CH 2 ) n S(CH 2 ) n —, and —(CH 2 ) n NC(═S)N(CH 2 ) n —, where each n is independently chosen from 0, 1, 2, 3, 4, 5, 6, 7, and 8, and wherein each carbon and nitrogen can be optionally substituted with one or more substituents independently chosen from hydroxyl, halo, alkoxy, alkyl, amino, —NR 2 R 3 , —NSO 2 R 4 , —NC(═O)NR 2 R 3 , heteroaryl, aryl, cycloalkyl, and heterocyclic; wherein —R 2 and —R 3 are independently chosen from —H, alkyl, and —C(═O)OR 4 ; and wherein R 4 is C 1 -C 4 alkyl; L 2 can be saturated, partially saturated, or unsaturated, and is chosen from —(CH 2 ) n —(CH 2 ) n —, —(CH 2 ) n C(═O)(CH 2 ) n —, —(CH 2 ) n C(═O)N(CH 2 ) n —, —(CH 2 ) n NC(═O)O(CH 2 ) n —, —(CH 2 ) n NC(═O)N(CH 2 ) n —, —(CH 2 ) n NC(═S)S(CH 2 ) n —, —(CH 2 ) n OC(═O)S(CH 2 ) n —, —(CH 2 ) n NH(CH 2 ) n —, —(CH 2 ) n O(CH 2 ) n —, —(CH 2 ) n S(CH 2 ) n —, and —(CH 2 ) n NC(═S)N(CH 2 ) n —, where each n is independently chosen from 0, 1, 2, 3, 4, 5, 6, 7, and 8, and wherein each carbon and nitrogen can be optionally substituted with one or more substituents independently chosen from hydroxyl, halo, alkoxy, alkyl, amino, —NR 2 R 3 , —NSO 2 R 4 , —NC(═O)NR 2 R 3 , heteroaryl, aryl, cycloalkyl, and heterocyclic; wherein —R 2 and —R 3 are independently chosen from —H, alkyl, and —C(═O)OR 4 ; and wherein R 4 is C 1 -C 4 alkyl; and pharmaceutically acceptable salts thereof.