Patent ID: 8703760

Claim:
A compound of formula IIa: wherein: X a is N or CH; R 1e is i) an alkyl optionally substituted with an aryl or a halogen, ii) an alkoxy optionally substituted with an aryl, a halogen, or a cycloalkyl, iii) an alkylthio optionally substituted with an aryl, a halogen, or a cycloalkyl, iv) an alkenyl, v) cyano, vi) a cycloalkyl, vii) a halogen, or viii) an amino optionally substituted with 1 or 2 alkyl; R 1f is hydrogen, an alkyl, an alkoxy, hydroxyl, cyano, or a halogen; R 21 is pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isoxazolyl, oxazolyl, triazolyl, pyrazinyl, pyridazinyl, pyrimidyl, pyridyl, or quinolyl, each of which may be substituted with the same or different 1-3 substituents selected from the group consisting of an optionally substituted alkyl; an optionally substituted alkoxy; an optionally substituted alkylthio; an alkenyl; a halogen; cyano; a carbamoyl optionally substituted with 1 or 2 alkyl; an amino optionally substituted with 1 or 2 alkyl; hydroxyl; an alkanoyl; a cycloalkylcarbonyl; an arylcarbonyl; nitro; an optionally substituted aliphatic heteromonocyclic group; an aryl; and a heteroaryl, and R 31 is pyridyl, pyrazinyl, pyrimidyl, or pyridazinyl, each of which may be substituted with the same or different 1-3 substituents selected from the group consisting of an optionally substituted alkyl; an optionally substituted alkoxy; an optionally substituted alkylthio; a cycloalkyl; an amino optionally substituted with 1 or 2 alkyl; an aliphatic heteromonocycle; and a halogen, or a pharmaceutically acceptable salt thereof.