Patent ID: 7678785

Claim:
A compound having the structure of Formula I: wherein, n is 0; R 1 and R 2 together with the nitrogen atom to which they are attached form a 4- to 8-membered heterocycloalkyl or heterocycloalkenyl group which is optionally substituted with 1 or 2 independently selected R x groups; Ar is phenyl that is substituted with OCH 2 -phenyl wherein the OCH 2 -phenyl is optionally substituted with 1 or 2 independently selected R x groups; R 3 is L 1 -L 2 -R 4 , where L 1 a bond; L 2 is selected from a bond, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 2 -C 6 )heteroalkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 2 -C 8 )heterocycloalkyl and (C 2 -C 8 )heterocycloalkenyl; wherein the (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 2 -C 6 )heteroalkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 2 -C 8 )heterocycloalkyl, and (C 2 -C 8 )heterocycloalkenyl is optionally substituted with 1 or 2 independently selected R x groups; R 4 is selected from H, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl, wherein the cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl is optionally substituted with 1 or 2 independently selected R x groups; R x is L s1 L s2 R s , wherein each L s1 and L s2 is independently selected from a bond, —O, —C(═O)—, —S—, —S(═O)—, —S(═O) 2 —, —NH—, —NHC(O)—, —C(O)NH—, S(═O) 2 NH—, —NHS(═O) 2 , —OC(O)NH—, —NHC(O)O—, (C 1 -C 6 ) alkyl, and —(C 2 -C 6 ) alkenyl; and R s is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, alkylsulfoxide, arylsulfoxide, alkylsulfone, arylsulfone, cyano, halo, isocyanato, thiocyanato, isothiocyanato, nitro, perhaloalkyl, perfluoroalkyl, silyl, and amino, including mono- and di-substituted amino groups; or a pharmaceutically acceptable salt, tautomer, or optical isomer thereof.