Patent ID: 8431157

Claim:
A pharmaceutical form comprising a core having an active pharmaceutical ingredient and a polymer coating of a partially neutralized anionic (meth)acrylate copolymer comprising free-radical polymerized units of 25 to 95% by weight C1- to C4-alkyl esters of acrylic or of methacrylic acid and 5 to 75% by weight (meth)acrylate monomers having an anionic group, where 0.1 to 25% of the contained anionic groups are neutralized by a base, wherein the base is lysine or a cationic, organic base having a molecular weight above 150 selected from the group consisting of histidine, arginine, a polyhistidine, a polyarginine, a polylysine, a phospholipid, a ribonucleoside, a deoxyribonucleoside, and a base from cationic surface active excipients or emulsifiers, wherein the coating, in the USP 28 release test for 2 hours at pH 1.2 followed by a change in the buffer to obtain a pH in the range of 5.5 to 7.5 at which active ingredient release starts, releases 90% of the contained active ingredient in not more than 90% of the time which elapses in the same release test for 2 hours at pH 1.2 followed by a change in the buffer to obtain the same pH at which active ingredient release starts with a comparable pharmaceutical form with the same active ingredient and partially neutralized anionic polymer but with partial neutralization by bases other than lysine or a cationic, organic base having a molecular weight above 150.