Patent ID: 7939492

Claim:
A method for treating a gram negative bacterial infection in a subject comprising administering an amount of a recombinant Factor C peptide effective for producing bacteriostasis, wherein the Factor C peptide: (a) is encoded by a nucleic acid having the sequence of SEQ ID NO:3, or (b) comprises a lipopolysaccharide binding peptide selected from at least one of sushi-1 Δ (SEQ ID NO:6), sushi-3 Δ peptide (SEQ ID NO:8), sushi-4 peptide (SEQ ID NO:9), sushi-5 peptide (SEQ ID NO: 10), sushi-6-vg1 peptide (SEQ ID NO: 11), sushi-7-vg2peptide (SEQ ID NO: 12), sushi-8-vg3 peptide (SEQ ID NO: 13), and sushi-9-vg4 peptide (SEQ ID NO: 14); or (c) consists of an endotoxin/lipid A binding fragment within the first 350 residues of SEQ ID NO:4, and wherein the fragment comprises residues 29-330 of SEQ ID NO:4, residues 29-201 of SEQ ID NO:4, or residues 264-330 of SEQ ID NO:4; or (d) consists of an endotoxin/lipid A binding fragment within the first 350 residues of SEQ ID NO:4, and wherein the fragment comprises amino acid residues 60-70, 170-185,270-280, or any combination thereof, of SEQ ID NO:4; or (e) consists essentially of sushi-1 peptide (SEQ ID NO:5), or sushi-3 peptide (SEQ ID NO:7).