Patent ID: 6995237

Claim:
An immunomodulatory peptide construct with the formula P 1 -X-P 2 where P 1 is a peptide associated with autoimmune disease, allergy or asthma, or host-versus-graft rejection and which will bind to an antigen receptor on a set or subset of T cells; P 2 is an immune modulating peptide which will (i) cause a directed immune response by said set or subset of T cells to which the peptide P 1 is attached or (ii) bind to a T cell receptor which will cause said set or subset of T cells to which the peptide P 1 is attached to initiate, but not complete, an immune response causing said set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P 1 and P 2 wherein the immunomodulatory peptide construct with the formula P 1 -X-P 2 is selected from the group consisting of SEQ ID NO: 14, SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38 and SEQ ID NO: 39.