Patent ID: 6998131

Claim:
A spot-on formulation for the treatment or prophylaxis of parasite infestation in mammals or birds which comprises (1) a composition comprising (A) an effective amount of at least one compound of the formula in which: R 1 is a halogen, CN or methyl; R 2 is —S(O) n R 3 , 4,5-dicyanoimidazol-2-yl, haloalkyl; R 3 is alkyl or haloalkyl; R 4 represents hydrogen halogen atom, NR 5 R 6 , —S(O) m R 7 , —C(O)R 7 —C(O)OR 7 , alkyl, haloalkyl, OR 8 or —N═C(R 9 )(R 10 ); R 5 and R 6 independently represent hydrogen, alkyl, haloalkyl, —C(O)alkyl, —S(O) r CF 3 or alkoxycarbonyl or R 5 and R 6 together form a divalent alkylene radical which is optionally interrupted by one or two divalent heteroatoms; R 7 represents alkyl or haloalkyl; R 8 represents hydrogen alkyl or haloalkyl; R 9 represents hydrogen or alkyl; R 10 represents an optionally substituted aryl or an optionally substituted heteroaryl group; R 11 and R 12 represent, independently of one another, hydrogen, halogen CN or NO 2 ; R 13 represents halogen haloalkyl, haloalkoxy, S(O) q CF 3 or SF 5 group; m, n, q and r represent, independently of one another, an integer equal to 0, 1 or 2; X represents a trivalent nitrogen atom or a C—R 12 radical, the three other valencies of the carbon atom forming part of the aromatic ring; with the proviso that, when R 1 is methyl, then either R 3 is haloalkyl, R 4 is NH 2 , R 11 is Cl, R 13 is CF 3 and X is N or else R 2 is 4,5-dicyanoimidazol-2-yl, R 4 is Cl, R 11 is Cl, R 13 is CF 3 and X is C—Cl; and (B) an effective amount of emamectin or a salt thereof; (2) a pharmaceutically or veterinary acceptable liquid carrier vehicle; and (3) optionally, a crystallization inhibitor.