Patent ID: 7622594

Claim:
A compound of Formula (IA) wherein: R 1 is aryl or C 3 -C 7 cycloalkyl, each optionally independently substituted with one to three substituent groups selected from C 1 -C 3 alkyl, hydroxy, halogen, oxo, methoxy, amino wherein the nitrogen atom is optionally independently mono- or disubstituted with a methyl group, or thiomethyl wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone; R 2 is hydrogen or a halogen; A is N; B is CH; C and E are each a bond; D is —CR 4 R 5 —, where R 4 is —CF 3 and R 5 is —OH; and R 3 is heteroaryl independently substituted with one to three substituent groups, wherein each substituent group of R 3 is independently aryl, C 1 -C 5 alkyl, C 1 -C 5 alkenyl, cycloalkyl, cycloalkenyl, acyl, alkoxycarbonyl, C 1 -C 5 alkanoyloxy, C 1 -C 5 alkanoyl, aroyl, C 1 -C 5 alkanoylamino, alkylaminocarbonyl, dialkylaminocarbonyl, aminocarbonyloxy, C 1 -C 5 alkylaminocarbonyloxy, C 1 -C 5 dialkylaminocarbonyloxy, C 1 -C 5 alkanoylamino, C 1 -C 5 alkoxycarbonylamino, C 1 -C 5 alkylsulfonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, C 1 -C 5 alkyloxy, aryloxy, halogen, hydroxy, oxo, cyano, trifluoromethyl, nitro, carboxyl, aminocarbonyl, amino wherein the nitrogen atom is optionally independently mono- or disubstituted with a C 1 -C 5 alkyl, or C 1 -C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone, wherein each substituent group of R 3 is optionally independently substituted with one to three substituents selected from aryl, acyl, C 1 -C 5 alkyl, C 1 -C 5 alkanoyloxy, C 1 -C 5 alkanoyl, C 1 -C 5 alkanoylamino, alkylaminocarbonyl, dialkylaminocarbonyl, C 1 -C 5 alkylsulfonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, C 1 -C 5 alkyloxy, C 1 -C 5 cycloalkyl, aryloxy, halogen, hydroxy, oxo, cyano, trifluoromethyl, nitro, aminocarbonyl, amino wherein the nitrogen atom is optionally independently mono- or disubstituted with a C 1 -C 5 alkyl, or alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone, or a tautomer ester, amide or salt thereof.