Patent ID: 7442719

Claim:
A method for the treatment of a disease associated with reversible airways obstruction selected from the group consisting of asthma, chronic obstructive pulmonary disease (COPD), respiratory tract infection and upper respiratory tract disease, which comprises administrating a therapeutically effective amount of a compound of formula (I): wherein: m is an integer of from 2 to 8; n is an integer of from 3 to 11; with the proviso that m+n is 5 to 19; R 1 is —XSO 2 NR 6 R 7 wherein X is —(CH 2 ) p — or C 2-6 alkenylene; R 6 and R 7 are independently selected from hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C(O)NR 8 R 9 , phenyl, and phenyl(C 1-4 alkyl)-, or R 6 and R 7 , together with the nitrogen to which they are bonded, form a 5-, 6-, or 7-membered nitrogen containing ring, and R 6 and R 7 are each optionally substituted by one or two groups selected from halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, hydroxy-substituted C 1-6 alkoxy, —CO 2 R 8 , —SO 2 NR 8 R 9 , —CONR 8 R 9 , —NR 8 C(O)R 9 , or a 5-, 6- or 7-membered heterocylic ring; R 8 and R 9 are independently selected from hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, and phenyl(C 1-4 alkyl)-; and p is an integer of from 0 to 6; R 2 and R 3 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halo, phenyl, and C 1-6 haloalkyl; and R 4 and R 5 are independently selected from hydrogen and C 1-4 alkyl with the proviso that the total number of carbon atoms in R 4 and R 5 is not more than 4, or a pharmaceutically acceptable salt, or solvate thereof, to the mammal.