Patent ID: 8288525

Claim:
A double-stranded ribonucleic acid (dsRNA), wherein said dsRNA comprises a sense strand and an antisense strand that form a duplex structure, wherein the antisense strand consists of the sequence of SEQ ID NO:90 and the sense strand consists of the sequence of SEQ ID NO:89, wherein each strand is modified as follows to include a 2â€²-O-methyl ribonucleotide as indicated by a lower case letter â€œcâ€ or â€œuâ€ and a phosphorothioate as indicated by a lower case letter â€œsâ€; SEQ ID NO:89 is cuGGcuGAAuuucAGAGcATsT and SEQ ID NO:90 is UGCUCUGAAAUUcAGCcAGTsT, and wherein said dsRNA targets cleavage of a CD45 mRNA.