Patent ID: 8206593

Claim:
A method for solvent exchange using a microfluidic device, said method comprising: i) providing a microfluidic device comprising a reactor, wherein said reactor a) is configured to fluidically communicate with at least one microfluidic channel; b) is configured to be fluidically isolated; and c) is defined by a wall at least a portion of which is permeable to a gas but substantially impermeable to a liquid corresponding to the gas; ii) introducing into the reactor a first solvent system comprising a first reactant; iii) fluidically isolating the reactor; iv) allowing some or all of the first solvent system to evaporate from the fluidically isolated reactor through said gas permeable wall or wall portion while retaining the first reactant in the reactor; and then v) introducing into the reactor a second solvent system different from the first solvent system.