Patent ID: 7709018

Claim:
An osteoconductive and osteoinductive multilayer composite material comprising: (I) an inner matrix composite material comprising: (i) hyaluronic acid and a hyaluronic acid derivative, wherein said hyaluronic acid derivative is in a form selected from the group consisting of a non-woven material, a woven material, a compact membrane or film, and a perforated membrane or film; and (ii) demineralised bone and/or biocompatible and biodegradable ceramic and/or bone of autologous or allogenic or animal origin, and (II) at least two layers, each layer comprising a hyaluronic acid derivative, wherein the hyaluronic acid derivatives in (I)(i) and (II) are each selected from the group consisting of: (a) an ester of hyaluronic acid, (b) an inner ester of hyaluronic acid, (c) an amide of hyaluronic acid, (d) an O-sulphated derivative of hyaluronic acid, (e) a deacetylated derivative of hyaluronic acid, and (f) a percarboxylated derivative of hyaluronic acid, and wherein said at least two layers (II) are superimposed on said inner matrix (I) thereby sandwiching said inner matrix (I) between said layers (II).