Patent ID: 8178564

Claim:
A method of treatment of metastatic colorectal cancer comprising administering to a patient afflicted with metastatic colorectal cancer and not previously treated systemically for said cancer, leucovorin, at a dosage of about 400 mg/m 2 , as a 2 hour infusion, the administration of the leucovorin being followed by a 5-fluorouracil (5-FU) bolus at a dosage of about 400 mg/m 2 ; the 5-FU bolus being followed by 5-FU at a dosage of about 2,400 mg/m 2 administered as a 46 hour continuous infusion; wherein the leucovorin and the 5-FU are administered to the patient every 2 weeks and administering about 60-150 mg/m 2 of picoplatin to the patient simultaneously with the leucovorin every 4 weeks, wherein at least the initial dose of picoplatin is about 150 mg/m 2 wherein a cumulative dose of picoplatin of greater than about 900 mg/m 2 is delivered to the patient.