Patent ID: 7268132

Claim:
A compound of the formula (II): wherein ring A, together with the carbon atoms to which it is attached is selected from: a) a 6-membered carbocyclic ring in which from 1 to 3 carbon atoms may be replaced by hetero atoms selected from oxygen, nitrogen and sulfur; and b) a 5-membered carbocyclic ring in which either: i) one carbon atom may be replaced with an oxygen, nitrogen, or sulfur atom; ii) two carbon atoms may be replaced with a sulfur and a nitrogen atom, an oxygen and a nitrogen atom, or two nitrogen atoms; or iii) three carbon atoms maybe replaced with three nitrogen atoms, one oxygen and two nitrogen atoms) or one sulfur and two nitrogen atoms; ring A and the phenylene ring are each independently optionally substituted with ore to three groups selected from F, Cl, Br, I, OH, OR 8 , NH 2 , NR a R b , NHOH, NO 2 , CN, CF 3 , CF 2 CF 3 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 3 -C 7 cycloalkyl, heterocyclyl, C 6 -C 10 aryl, heteroaryl, arylalkyl, C(═O)R a , COOH, CO 2 R a , O—C(═O)R a , C(═O)NR a R b , NR a C(═O)R b , NR a CO 2 R b , OC(═O)NR a R b , —NR a C(═O)NR a R b , —NR a C(═S)NR a R b , and —SO 2 NR a R b , wherein R a and R b are each independently hydrogen, C 1 -C 6 alkyl, or C 6 -C 10 aryl; X is —(CH 2 ) m —, —O—, —S(O) n —, —N(R 5 )—, —CH═CH—, or —CH 2 —CH═CH—; R 1 -R 4 are the same or different and are each selected from H, lower alkyl, —OH, and —CH(R 6 )—CONR 7 R 8 ; or any of R 1 -R 4 can be taken together to form a 3-7 member carbocyclic or heterocyclic ring; R 5 is H, lower alkyl, or —OH; R 6 , R 7 and R 8 are each independently H or lower alkyl; m is 0, 1, 2 or 3; n is; or the stereoisomeric forms, mixtures of stereoisomeric forms, or pharmaceutically acceptable salt or ester forms thereof.