Patent ID: 7928111

Claim:
A comestible composition comprising at least a sweet flavor entity selected from the group consisting of sucrose, sucralose, and combinations thereof; and a compound of structural Formula (IIc): or a pharmaceutically acceptable salt thereof, wherein: A is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, —CN, —OR 9 , —NR 9 COR 10 , —NHOR 9 ,—NR 9 R 10 , —NR 9 CO 2 R 10 , —NR 9 CONR 10 R 11 , —NR 9 CSNR 10 R 11 , or —NR 9 C(═NH)NR 10 R 11 ; R 17 is hydrogen, alkyl, substituted alkyl; W is —S—; Y is —C(R 26 )—; Z is —C(R 27 )—; R 26 is hydrogen, alkyl, substituted alkyl, —OR 31 , —CONR 31 R 32 , or —CO 2 R 31 ; R 27 is hydrogen, alkyl, substituted alkyl, —OR 33 , —CONR 33 R 34 , or —CO 2 R 33 and R 9 , R 10 , R 11 , R 31 , R 32 , R 33 , and R 34 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; alternatively R 10 and R 11 , R 31 and R 32 , or R 33 and R 34 together with the atoms to which they are bonded form a heterocycloalkyl or substituted heterocycloalkyl ring; wherein the substituted alkyl, substituted aryl, substituted arylalkyl, substituted heteroalkyl, substituted heteroaryl, substituted heteroarylalkyl, and substituted heterocycloalkyl each independently comprises one or more substituent groups selected from the group consisting of —R a , halo, ═O, —OR b , —SR b , ═S, —NR c R c , ═NR b , ═N—OR b , trihalomethyl, —CN, —NO 2 , S(O) 2 R b , —S(O) 2 NR b , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 OR b , —P(O)(OR b )(OR b ), —C(O)R b , —C(NR b )R b , —C(O)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC(O)OR b , —NR b C(O)R b , —NR b C(O)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b and —NR b C(NR b )NR c R c , where R a is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; each R b is independently hydrogen or R a ; and each R c is independently R b or alternatively, the two R c s are taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl.