Patent ID: 7279490

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof: wherein, R 1 represents R 8 , (CH 2 ) n OR 8 , COOR,COOR 8 , (CH 2 ) n N(R)(R 8 ), (CH 2 ) n N + (R) 3 , (CH 2 ) n NRCOR, (CH 2 ) n N(R 8 )CO 2 R, (CH 2 ) n N(R 8 )COR, (CH 2 ) n NRCO 2 R, SO 2 R, SO 2 N(R) 2 , (CH 2 ) n CON(R) 2 , CONRR 8 , CONHC(R) 3 ,COR, COR 8 , CON(R 8 ) 2 , nitro, or cyano; Z represents CH 2 , CO, CHCO 2 R, or SO 2 ; Ar represents (CH 2 ) n 5-11 heterocyclyl, (CH 2 ) n C 5-10 heteroaryl, or (CH 2 ) n C 6-10 aryl, said heterocycle, aryl or heteroaryl optionally substituted with 1-3 groups of R a ; R a represents C 1 -C 6 alkyl optionally substituted with fluoro, C 2-6 alkenyl, C 2-6 alkynyl, F, Cl, I, Br, (CH 2 ) n NR 2 , (CH 2 ) n NRR 8 , NO 2 , CN, —CF 3 , —COR, —COR 8 , —CONRR 8 , —CONR 2 , —(CH 2 ) n COOR, —(CH 2 ) n NHCOR, —(CH 2 ) n NHCOR 8 , —(CH 2 ) n NHCOOR, —SO 2 NR 2 , —SiR 3 , —(CH 2 ) n OR, —(CH 2 ) n OR 8 , —O(CH 2 ) n OR, —(CH 2 ) n O(CH 2 ) n OR, —S(O) m R, —S(O) m R 8 , —C(NH)NH 2 , R 8 R represents hydrogen, C 1-6 alkyl optionally substituted with fluoro, C 2-6 alkenyl, or C 2-6 alkynyl; R 8 represents (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n C 5-11 heterocycle, (CH 2 ) n C 5-10 heteroaryl, (CH 2 ) n C 6-10 aryl, said heterocycle, aryl or heteroaryl optionally substituted with 1-3 groups of R b ; R b represents F, Cl, I, Br, or C 1-6 alkyl n is 0-3 m is 0-2.