Patent ID: 8383657

Claim:
A pharmaceutical compostition comprising a therapeutically effective amount of a compound of formula (I): wherein R 1 is hydrogen, methyl, phenyl, pyrazolyl, or hydroxyl; R 2 is hydrogen, alkyl, alkenyl, ═CH 2 , or ═CHR c wherein the alkyl group and the alkenyl group are substituted with 0, 1, 2, or 3 substituents independently selected from the group consisting of alkoxycarbonyl, alkylcarbonyloxy, aryl, aryloxy, arylalkoxy, carboxy, cyano, cycloalkyl, haloalkoxy, heteroaryl, heterocycle, hydroxyl, nitro, and R d R e N—, wherein a group represented by R 2 can be further substituted with 0, 1, or 2 groups selected from halo and alkoxy; R c is alkyl or halo; R d and R e are each independently hydrogen, alkyl, alkoxyalkyl, aryl, arylalkyl, cyanoalkyl, heteroaryl, heteroarylalkyl, heterocycle, or heterocyclealkyl; R 3 is optionally substituted phenyl or naphthyl; R 4 is optionally substituted heterocycle; and a is single or double bond; provided that when R 1 is hydroxyl or when R 2 is a radical attached to the thiazole ring through an exocyclic double bond, then a is single bond; and provided that when a is double bond, R 1 is hydrogen, R 2 is methyl, R 3 is phenyl substituted with 3-haloalkyl, 3-halo, 3-haloalkoxy, 2,5-dihalo, 2,3-dihalo, 3,4-dihalo, or 3,5-dihalo, then R 4 is heterocycle; or a pharmaceutically acceptable salt, thereof, in combinaton with a pharmaceutically acceptable carrier.