Patent ID: 7910324

Claim:
A method of screening for compounds which affect the cleavage activity of EphA4 by γ-secretase, comprising the following steps: (i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition that contains EphA4 in the presence of a candidate compound, and separately contacting said first biological composition with said second biological composition in the absence of a candidate compound, to allow EphA4 to be cleaved; (ii) measuring the cleavage of the EphA4 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA4 by γ-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the cleavage activity of EphA4 by γ-secretase.