Patent ID: 8598154

Claim:
A compound having the formula: wherein L 1 is selected from the group consisting of a bond, —C(O)O—C 0-6 alkylene, C 1-6 alkylene and C 1-6 heteroalkylene; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl, heteroaryl, —OR 1a , NR 1c R 1d , and —C(O)NR 1c R 1d , wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups are optionally substituted with hydrogen, C 1-6 alkyl, hydroxy and C 1-6 alkoxy; each R 1a is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 1-6 alkylC 3-8 cycloalkyl, C 3-8 heterocycloalkyl, C 1-6 alkylC 3-8 heterocycloalkyl, aryl, C 1-6 alkylaryl, heteroaryl and C 1-6 alkylheteroaryl; each of R 1c and R 1d are independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl, and heteroaryl; alternatively, R 1c and R 1d are combined to form a C 3-8 heterocycloalkyl having from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, and optionally substituted with 1 to 3 groups each independently selected from the group consisting of hydrogen, C 1-6 alkyl, hydroxy and C 1-6 alkoxy; ring J is a heteroaryl ring having from 5 to 6 ring members and from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, wherein at least one heteroatom is N; each of R 2 and R 3 are independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl and heteroaryl; R 4 is selected from the group consisting of hydrogen, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl and heteroaryl; alternatively R 2 is combined with R 3 or R 4 to form a C 3-8 heterocycloalkyl having from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, and optionally substituted with 1 to 3 R 2a groups, wherein each R 2a is independently selected from the group consisting of hydrogen, C 1-6 alkyl, halogen, C 1-6 haloalkyl, hydroxy, C 1-6 alkoxy, C 1-6 haloalkoxy, nitro, cyano, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl and heteroaryl; subscript n is 0 or 1; each R 5a is independently selected from the group consisting of hydrogen, halogen, —OR 5a1 , —NR 5a2 R 5a3 , —S(O 2 )NR 5a2 R 5a3 , —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl, and heteroaryl; each of R 5a1 , R 5a2 and R 5a3 are independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl, and heteroaryl; wherein when R 4 is hydrogen, subscript n is 1; and salts and isomers thereof.