Patent ID: 7939538

Claim:
A compound having the formula (I): or a pharmaceutically acceptable salt or prodrug thereof, wherein A 1 is C(R b ); A 4 or N; Q is a member selected from the group consisting of a bond, (C 1 -C 8 )alkylene, (C 2 -C 8 )heteroalkylene, —C(O)—, —OC(O)—, —CH 2 CO—, —CH 2 SO— and —CH 2 SO 2 —; L is a bond or (C 1 -C 5 )alkylene; X is —CH 2 —, or —C(O)—; R a is selected from the group consisting of hydrogen, —OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, —CO 2 R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O) 2 R′, —NH—C(NH 2 )═NH, —NR′C(NH 2 )═NH, —NH—C(NH 2 )═NR′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR′R″, —CN and —NO 2 ; R b is selected from the group consisting of hydrogen, —OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, —CO 2 R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O) 2 R′, —NH—C(NH 2 )═NH, —NR′C(NH 2 )═NH, —NH—C(NH 2 )═NR′, —R′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR′R″, —CN and —NO 2 ; the subscript n is 0, 1 or 2: each R′, R″ and R′″ independently is H, unsubstituted (C 1 -C 8 )alkyl, heteroalkyl, unsubstituted aryl, or substituted aryl; R 1 is heteroaryl or aryl; R 2 is a member selected from the group consisting of hydrogen, halogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )heteroalkyl, hetero(C 1 -C 10 )cycloalkyl, (C 1 -C 10 )alkylaryl, and (C 2 -C 10 )heteroalkylaryl; R 3 is a member selected from the group consisting of —S(O) m R 5 , —S(O) m N(R 8 )R 9 , —S(O) m N(R 8 )CH 2 R 6 , —N(R 8 )SO 2 R 5 , R 4 is a member selected from the group consisting of (C 1 -C 20 )alkyl, (C 2 -C 20 )heteroalkyl, heteroaryl, aryl, heteroaryl(C 1 -C 6 )alkyl, heteroaryl(C 2 -C 6 )heteroalkyl, aryl(C 1 -C 6 )alkyl and aryl(C 2 -C 6 )heteroalkyl; R 5 is selected from the group consisting of (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, aryl and heteroaryl; R 6 and R 7 independently are hydrogen, (C 1 -C 8 )alkyl or (C 2 -C 8 )heteroalkyl; R 8 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, heteroaryl or aryl; R 9 is (C 1 -C 8 )alkyl; Z is CH or N; X 1 is a bond, (C 1 -C 6 )alkylene or (C 1 -C 6 )heteroalkylene; Y 1 is (C 1 -C 6 )alkylene; and the subscript m is 0, 1 or 2.