Patent ID: 6867198

Claim:
A compound of Formula I where: A and B are independently O or S; X and Y are both hydrogen or, taken together, form a bond; R 1 is hydrogen or C 1 -C 4 alkyl; R 2 is optionally up to two substituents independently selected from the group consisting of halo, cyano, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkoxy, aryloxy, benzyloxy, C 1 -C 6 alkylthio and arylthio; R 3 is a substituent optionally selected from the group consisting of aryl heteroaryl, —CH 2 —NH— (1-deoxy-β-D-glucose), and —(CH 2 ) m —Z; R 4 is hydrogen, C 1 -C 4 alkyl, —(CH 2 ) m —Z, or 2-deoxy-α-D-ribofuranos-1-yl; R 5 is optionally up to two substituents independently selected from the group consisting of halo, cyano, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkoxy, aryloxy, benzyloxy, C 1 -C 6 alkylthio and arylthio; R 6 is optionally up to three substituents selected from C 1 -C 4 alkyl; R 7 is a substituent optionally selected from (C 1 -C 6 alkoxy)carbonyl or —(CH 2 ) m —Z; Z is halo, hydroxy, (C 1 -C 6 alkyl) 3 SiO—, (diphenyl) (C 1 -C 6 alkyl)SiO, carboxy, (C 1 -C 4 alkoxy)carbonyl, or NR 8 R 9 ; R 8 is hydrogen, C 1 -C 6 alkyl, or substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl; R 9 is hydrogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkanoyl, substituted C 1 -C 6 alkanoyl, tert-butoxycarbonyl, benzyloxycarbonyl, an amino acid residue, a protected amino acid residue, β-(pyridinyl)alaninyl, aryl, heteroaryl, arylcarbonyl, or heteroarylcarbonyl; or R 8 and R 9 taken together with the nitrogen to which they are attached form a saturated heterocycle optionally substituted with one or two hydroxy, amino, or C 1 -C 6 alkyl groups; Q 1 is O, S(O) n or —(CH 2 ) 1-3 —; Q 2 is a carbon-carbon single bond, a carbon-carbon double bond, —NR 10 —, or —NR 10 —CHR 11 —; Q 3 is —(CH 2 ) 1-3 —; R 10 is hydrogen, (C 1 -C 6 alkyl)sulfonyl, arylsulfonyl, hetroarylsulfonyl, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, (C 1 -C 5 alkyl)carbonyl, substituted (C 1 -C 5 alkyl)carbonyl, an amino acid residue, a protected amino acid residue, β-(pyridinyl)alaninyl, aryl, heteroaryl, arylcarbonyl, or heteroarylcarbonyl; R 11 is hydrogen, C 1 -C 6 alkyl, or substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl; or R 10 and R 11 taken together with the atoms to which they are attached form a 5- or 6-membered saturated heterocycle; m is 0, 1, 2, 3, 4, or 5; n is 0, 1, or 2; or a pharmaceutically acceptable salt thereof.