Patent ID: 8722042

Claim:
A method for treating Alzheimer's disease in a subject in need thereof, comprising the sequential steps of: (a) determining ventricular volume in the subject's brain by magnetic resonance imaging (MRI), thereby obtaining a baseline value of ventricular volume; (b) administering a brain preserving therapeutic agent to the subject for the purpose of treating Alzheimer's disease during a first time period; (c) determining ventricular volume in the subject's brain by MRI, thereby obtaining a first intermediate value of ventricular volume; (d) comparing the intermediate value from step (c) with the baseline value from step (a); and (e) increasing administration of the brain preserving therapeutic agent in dose or frequency if step (d) indicates an increase from the baseline value to the first intermediate value and the increase is equal to or greater than an expected increase in ventricular volume in a subject with Alzheimer's disease within a time period of the same duration as the first time period but without receiving treatment for the disease, and maintaining administration of the brain preserving therapeutic agent in dose or frequency if step (d) indicates no increase from the baseline value to the first intermediate value or indicates an increase that is less than an expected increase in ventricular volume in a subject with Alzheimer's disease within a time period of the same duration as the first time period but without receiving treatment for the disease.