Patent ID: 7906283

Claim:
A method of screening human patients to identify those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation after treatment with a selective serotonin reuptake inhibitor (SSRI) and detecting the presence of a genotype in the patients which is associated with an increased risk of treatment-emergent suicidal ideation (TESI) after treatment with a SSRI comprising: (a) obtaining a sample of genetic material from the patients, (b) assaying the sample for the presence of a genotype in the patients which is associated with an increased risk of treatment-emergent suicidal ideation after treatment with a SSRI by performing an assay suitable for detection of a polymorphism, and (c) identifying those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation after treatment with a SSRI based on the presence of the genotype associated with an increased risk of treatment-emergent suicidal ideation in (b), wherein the genotype is characterized by a polymorphism in each of the following genes: glutamine receptor, ionotropic, kainate 2 (GRIK2); glutamate receptor ionotropic AMPA 3 (GRIA3); glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A); neurotrophic tyrosine receptor kinase 2 (NTRK2); 5-hydroxytryptamine (serotonin) receptor 3B (HTR3B), glutamate receptor ionotropic AMPA 1 (GRIA1); papilin (PAPLN); and interleukin 28 receptor alpha (IL28RA); wherein when the gene is GRIK2, the polymorphism is located within intron 1 of GRIK2, and the polymorphism is the cytosine allele of marker rs2518224; wherein when the gene is GRIA3, the polymorphism is located within intron 3 of GRIA3, and the polymorphism is the guanine allele of marker rs4825476; wherein when the gene is GR1N2A, the polymorphism is located within intron 3 of GRIN2A, and the polymorphism is the cytosine allele of marker rs3104703; wherein when the gene is NTRK2, the polymorphism is located within intron 14 of NTRK2, and the polymorphism is the guanine allele of marker rs1573219; wherein when the gene is HTR3B, the polymorphism is located within intron 6 of HTR3B, and the polymorphism is the guanine allele of marker rs2276307; wherein when the gene is GRIA1, the polymorphism is located within intron 5 of GRIA1, and the polymorphism is the cytosine allele of marker rs4958672; wherein when the gene is PAPLN, the polymorphism is located within intron 13 of PAPLN, and the polymorphism is the thymine allele of marker rs11628713; wherein when the gene is IL28RA, the polymorphism is located within exon 7 of IL28RA, and the polymorphism is the guanine allele of marker rs10903034.