Patent ID: 8618103

Claim:
A compound of Formula I wherein: R is lower alkyl, lower haloalkyl, lower alkoxy, hydroxy lower alkyl, hydroxy, or halogen; n is 0 or 1; Z 1 is NH; Z 2 is CH; Z 3 is CR 1 ; R 1 is H, lower alkyl, cycloalkyl, cyano, cyano lower alkyl, or halogen; X is CH, CRâ€², or N; Xâ€² is CH, CRâ€², or N; r is 0 or 1; Y is CH, CRâ€², or N; Râ€² is Râ€² a or Râ€² b ; Râ€² a is halogen or cyano; Râ€² b is lower alkyl, cycloalkyl, heterocycloalkyl, ORâ€³, SRâ€³, S(â•O) 2 Râ€³, or NRâ€³Râ€³, optionally substituted with one or more Râ€² c ; Râ€² c is hydroxy, halogen, oxo, cyano, lower alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, carboxy lower alkyl, amino, amino carboxy lower alkyl, lower alkyl amino, lower dialkyl amino, lower haloalkyl, or lower alkoxy; m is 0 or 1; Râ€³ is H, lower alkyl, hydroxy lower alkyl, heteroaryl, or lower alkoxy; Q is H, S(â•O) 2 Q 1 , C(â•O)Q 2 , C(â•O)OQ 3 , or Q 4 ; Q 1 is lower alkyl, cycloalkyl lower alkyl, lower alkyl amino, lower dialkyl amino, or cycloalkyl, optionally substituted with one or more Q 1â€² ; each Q 1â€² is independently halogen, lower alkyl, cyano, or lower alkoxy; Q 2 is lower alkyl, cycloalkyl lower alkyl, or cycloalkyl, optionally substituted with one or more Q 2â€² ; each Q 2â€² is independently halogen, lower alkyl, cyano, or lower alkoxy; Q 3 is lower alkyl, cycloalkyl lower alkyl, or cycloalkyl, optionally substituted with one or more Q 3â€² ; each Q 3â€² is independently halogen, lower alkyl, or lower alkoxy; Q 4 is lower alkyl, cycloalkyl lower alkyl, heterocycloalkyl, or cycloalkyl, optionally substituted with one or more Q 4â€² ; each Q 4â€² is independently halogen, cyano, cyano lower alkyl, lower alkyl, or lower alkoxy; p is 0, 1, or 2; q is 1 or 2; each represents a single bond or a double bond; and with the proviso that the bonds between Z 1 and Z 2 and Z 2 and Z 3 are not both double bonds and are not both single bonds; or a pharmaceutically acceptable salt thereof.