Patent ID: 7008941

Claim:
A compound having the structure: or pharmaceutically acceptable salt or stereoisomer thereof, wherein A is —(CR 2 R 2a ) m — where m is 1, 2 or 3; B is —(CR 3 R 3a ) n — where n is 1, 2, 3 or 4; X is —N(R 4 )—, —O—, or —S—; R 2 and R 3 are, at each occurrence, the same or different and independently an amino acid side chain moiety or amino acid side chain derivative, a peptide or peptide derivative or a solid support; R 5 is an amino acid side chain moiety or amino acid side chain derivative; R 2a and R 3a are, at each occurrence, the same or different and independently hydrogen, hydroxy, —COOH, —CONH 2 , —R 6 , —OR 6 , —COOR 6 , —COR 6 or —CONHR 6 , where R 6 is lower alkyl optionally substituted with halogen or hydroxy; R 1 and R 4 are the same or different and chosen from a solid support, amino acid, peptide, protein, amino acid side chain moieties, amino acid side chain derivatives and peptide derivatives; and wherein R 1 and R 2 taken together optionally form a fused heterocycle or substituted heterocycle, wherein a substituted moiety has at least one hydrogen atom replaced with at least one substituent chosen from: halogen, oxo, hydroxy, haloalkyl, —R, —OR, C(═O)R, —C(═O)OR, C(═O)NRR, —NRR, NRC(═O)R, —NRC(═O)OR, NRC(═O)NRR, —OC(═O)R, OC(═O)OR, OC(═O)NRR, SH, —SR, —SOR, —SO 2 R, NRSO 2 R, —Si(R) 3 , and —OP(OR) 3 , wherein each occurrence of R is the same or different and independently an amino acid side chain moiety or an amino acid side chain derivative, hydrogen, alkyl, aryl, arylalkyl, heterocycle or heterocyclealkyl, or wherein any two R groups attached to the same nitrogen atom, taken together with the nitrogen atom to which they are attached, form a heterocyclic ring or a substituted heterocyclic ring.