Patent ID: 8198344

Claim:
A method of preparing a sterile cyanoacrylate adhesive composition with a controlled level of high viscosity and a fast curing speed comprising: a. mixing at least one poloxamer with a cyanoacrylate adhesive at a temperature of about 30° C. to about 70° C. for about 1 hour to about 3 hours to dissolve the poloxamer, initiate partial polymerization of the cyanoacrylate adhesive, and increase the viscosity of the adhesive composition to a desired level; b. after increasing the viscosity of the adhesive composition to the desired level according to step (a), adding a free radical polymerization inhibitor, an anionic polymerization inhibitor, or a combination thereof to the adhesive composition to quench the partial polymerization of the cyanoacrylate adhesive; and c. sterilizing the adhesive composition after quenching the partial polymerization according to step (b) to produce the sterile cyanoacrylate adhesive composition.