Patent ID: 6960609

Claim:
A compound of the formula (I): and pharmaceutically acceptable salts thereof; wherein R 1 is an aryl selected, from phenyl and naphthyl, wherein any of the above aryl moieties of R 1 may optionally be substituted with from one to three substituents independently selected from halogen, (C 1 -C 6 )alkyl optionally substituted with from one to seven fluorine atoms, phenyl, benzyl, hydroxy, acetyl, formyl, amino, cyano, nitro, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylamino, [(C 1 -C 6 )alkyl] 2 amino, benzylamino(C 1 -C 8 )alkyl,(C 1 -C 8 )alkylamino(C 1 -C 8 )alkyl, (R 6 ) 2 amino(C 1 -C 8 )alkyl wherein each R 6 is (C 1 -C 6 )alkyl or two R 6 groups join to form a saturated 4 to 6-membered ring optionally containing one heteroatom selected from O, N or S, said 4 to 6-membered ring optionally substituted by a (C 1 -C 6 )alkyl or a benzo group at any two adjacent carbon atoms, and wherein any of alkyl moieties in R 1 may optionally be substituted with from one to seven fluorine atoms; R 2 is halogen, aryl, heteroaryl, SO 2 R 7 , COR 7 , CONR 8 R 9 , COOR 7 , or C(OH)R 8 R 9 wherein each of R 7 , R 8 and R 9 is defined, independently, as R 1 is defined above, or R 7 and R 8 , together with the carbon or nitrogen to which they are both attached, form a three to seven membered saturated ring containing from zero to three heteroatoms selected, independently, from O, N and S, and wherein said aryl and heteroaryl are defined as such terms are defined above in the definition of R 1 , and wherein any of the aryl, heteroaryl and heterocyclic moieties of R 2 may optionally be substituted with from one to three substituents independently selected from halo, (C 1 -C 6 )alkyl optionally substituted with from one to seven fluorine atoms, phenyl, benzyl, hydroxy, acetyl, amino, cyano, nitro, (C 1 -C 6 )alkoxy optionally substituted with from one to seven fluorine atoms, (C 1 -C 6 )alkylamino and [(C 1 -C 6 )alkyl] 2 amino; R 3 is hydroxy, —(C 1 -C 6 )alkyl-OH, (C 1 -C 6 )alkoxy, —(C 1 -C 7 )alkyl-(C 1 -C 7 )alkoxy, NHSO 2 R 7 , C(OH)R 7 R 8 , fluorine, bromine, chlorine, iodine, triazolyl, tetrazolyl, heteroaryl, as defined for R 1 above or CONHR 7 , wherein R 7 and R 8 are the same or different and are selected from hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy and (C 1 -C 4 )alkoxy-(C 1 -C 4 )alky-1 having a total of 4 or less carbon atoms, and wherein any of the alkyl moieties of R 7 and R 8 may optionally be substituted with from one to seven fluorine atoms; and R 4 and R 5 are each, independently, (C 1 -C 8 )alkyl, (C 3 -C 7 )cycloalkyl-, or (C 3 -C 7 )cycloalkyl-(C 1 -C 8 )alkyl.