Patent ID: 8648196

Claim:
A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, or a salt thereof, comprising: (k) reacting a compound having formula (VII) or a salt thereof, wherein R 4 is alkyl, wherein R 5 is hydrogen or C(O)R 6 , wherein R 6 is alkyl, phenyl or naphthyl, each of which is unsubstituted or substituted with one or two or three of independently selected OCH 3 , OCH 2 CH 3 , F, Cl or Br, and a chlorinating agent and isolating or not isolating the product; and (l) reacting the product of step (k) and a hydroxide base.