Patent ID: 8344135

Claim:
A compound represented by the formula wherein R 1c is (1) C 1-6 alkyl-carbonyl optionally having 1 to 3 substituents selected from the group consisting of (i) hydroxy, (ii) C 1-6 alkyl-oxy, (iii) di-C 1-6 alkylamino, and (iv) a 5- or 6-membered nonaromatic heterocyclic group optionally having 1 or 2 substituents selected from (a) hydroxy, (b) halogen, (c) C 1-6 alkyl optionally substituted by hydroxy, and (d) C 3-8 cycloalkyl, (2) C 2-6 alkenyl-carbonyl having substituent(s) selected from the group consisting of (i) C 6-10 aryl optionally having 1 to 3 halogen atoms, and (ii) a 5- or 6-membered monocyclic aromatic heterocyclic group, (3) C 3-8 cycloalkyl-carbonyl optionally having 1 to 3 C 1-6 alkyl, or (4) 5- or 6-membered monocyclic aromatic heterocyclyl-carbonyl R 2c is C 6-10 aryl optionally having 1 or 2 substituents selected from the group consisting of (1) halogen, (2) C 3-8 cycloalkyl optionally having cyano, (3) C 1-6 alkyl-oxy optionally having 1 to 3 substituents selected from the group consisting of halogen and cyano, and (4) C 1-6 alkyl optionally having 1 to 3 substituents selected from the group consisting of halogen, C 2-6 alkynyl, and cyano; R 4c is hydrogen; X c is —O—, —NH—, or —N(CH 3 ) Y c is —NHCO— or —CONH— Z c is —S; Q c is ═CH—; and ring A c is a benzene ring optionally having 1 or 2 substituents selected from the group consisting of (1) C 1-6 alkyl optionally having 1 to 3 halogen atoms, (2) cyano, (3) halogen, and (4) C 1-6 alkyl-oxy; or a salt thereof.