Patent ID: 7205296

Claim:
A compound having the formula: wherein R 1 is a member selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 3-5 cycloalkyl, C 3-5 cycloalkyl-alkyl, benzyl, and substituted benzyl; R 2 is a member selected from the group consisting of H, and C 1-6 alkyl; R 3 is a member selected from the group consisting of H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-5 cycloalkyl, C 3-5 cycloalkyl-alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, halogen, cyano and —C(O)R 3a , wherein R 3a is a member selected from the group consisting of H, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, amino, C 1-6 alkylamino and di-C 1-6 alkylamino; R 4 is a member selected from the group consisting of H and C 1-6 alkyl; R 5 is a member selected from the group consisting of H, C 1-6 alkyl, C 1-6 haloalkyl, benzyl, aryl, C 1-6 alkyl-N—(R 5a ) 2 ; C 1-6 alkyl-O—(R 5a ); wherein each R 5a is a member independently selected from the group consisting of H, C 1-6 alkyl, and optionally, two R 5a groups attached to nitrogen are combined with the nitrogen atom to form an azetidine, pyrrolidine, piperidine or morpholine ring; Ar is an aromatic ring selected from the group consisting of benzene, pyridine, pyrazine and pyrimidine, each of which is optionally substituted with from 1–2 R 6 substituents, wherein each R 6 is independently selected from the group consisting of halogen, cyano, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 3-5 cycloalkyl-alkoxy, amino, C 1-6 alkylamino, di-C 1-6 alkylamino, —C(═NR 6a )—N(R 6b ) 2 , —C(O)R 6a , —O(CH 2 ) m OR 6b , —(CH 2 ) m OR 6b , —O(CH 2 ) m N(R 6b ) 2 and —(CH 2 ) m N(R 6b ) 2 , wherein each subscript m is independently an integer of from 1 to 3, each R 6a is a member independently selected from the group consisting of H, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, amino, C 1-6 alkylamino and di-C 1-6 alkylamino, and each R 6b is a member independently selected from the group consisting of H, C 1-4 alkyl and C 1-4 alkanoyl, and optionally, two R 6b groups attached to nitrogen are combined with the nitrogen atom to form an azetidine, pyrrolidine, piperidine or morpholine ring; L is a linking group selected from the group consisting of a bond and —NH—; R 7 is a member selected from the group consisting of H, halogen, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy and C 1-6 haloalkyl; and pharmaceutically acceptable salts thereof.