Patent ID: 7405212

Claim:
A fused bicyclo compound having the structure: or pharmaceutically acceptable salt or stereoisomer thereof, wherein Y is SO 2 —, —SO— or —S—; A is —(CR 4 R 4a ) m —; B is —(CR 5 R 5a ) n —; m is 1; n is 1; R 4 and R 5 are, at each occurrence, the same or different and independently an amino acid side chain moiety or an amino acid side chain derivative; R 4a and R 5a are, at each occurrence, the same or different and independently hydrogen, hydroxy, —COOH, —CONH 2 , —R 6 , —OR 6 , —COOR 6 , —COR 6 or —CONHR 6 ; R 6 is a lower alkyl optionally substituted with halogen or hydroxy; R 2 is -Z-(amino acid side chain moiety) or -Z-(amino acid side chain derivative), where Z is a direct bond or —C(═O)—, —C(═O)O—, —C(═O)NH—, —C(═NH)—, —SO 2 — or —P(O) 2,3 —; and R 1 is independently selected from a solid support, an amino acid side chain moiety, an amino acid side chain derivative, a peptide, a peptide derivative, a protein, -Z-(amino acid side chain moiety) or -Z-(amino acid side chain derivative), wherein Z is a direct bond or —C(═O)—, —C(═O)O—, —C(═O)NH—, —C(═NH)—, —SO 2 — or —P(O) 2,3 —; wherein any two adjacent CH groups or adjacent NH and CH groups of the fused bicyclo compound optionally form a double bond; and with the provisos that: (a) when Y is —S— or —SO—, R 1 is not hydrogen; and (b) when Y is —S— and m is 1, R 4 and R 4a are not both methyl when R 1 is —C(═O)W, where W is phenyl, benzyl, —CH 2 O(phenyl) or —OC(═O)(benzyl).