Patent ID: 8106077

Claim:
A compound of wherein p is 0, 1 or 2; X 1 is C and X 2 is C; R 1 and R 2 are independently selected from the group consisting of hydrogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 3 thiohaloalkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, and halo; R 3 is independently selected from the group consisting of hydrogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, and halo; R 4b is selected from the group consisting of hydrogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 3 -C 6 cycloalkyl, and C 4 -C 5 alkylcycloalkyl; R 5 and R 5a are independently selected from the group consisting of hydrogen, and C 1 -C 3 alkyl; R 6 is selected from the group consisting of hydrogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, halo, and —NO 2 ; L 1 is selected from the group consisting of a bond, CR a ═CR b , ethynyl, C 1 -C 3 alkyl-S—, C 1 -C 3 alkyl-O—, N(R c )—C 1 -C 3 alkyl, and —C 1 -C 3 alkyl-N(R c )—, wherein R a and R b are independently selected from the group consisting of hydrogen and C 1 -C 3 alkyl; and R c is independently selected from the group consisting of H, C 1 -C 5 alkyl, C 1 -C 3 alkylphenyl, and C 4 -C 8 alkylcycloalkyl; Ar 1 phenyl, optionally substituted with one or two groups independently selected from the group consisting of hydroxy, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, halo, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, —OC 1 -C 2 alkylphenyl, and NHC(O)R 10 ; R 7 is selected from the group consisting of —COOH, —C 1 -C 3 alkylCOOH, —O—C 1 -C 3 alkylCOOH, —C 3 -C 8 cycloalkylCOOH and, —CONR 11 R 11 ; each R 10 is independently selected from the group consisting of hydrogen, C 1 -C 3 alkyl, and phenyl; each R 11 is independently hydrogen, or C 1 -C 5 alkyl; or a pharmaceutically acceptable salt thereof.