Patent ID: 7960134

Claim:
A process for screening or designing wild type c-Met inhibitors comprising: a) crystallizing the wild type c-Met kinase domain of SEQ ID NO:2 bound to (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione, wherein the resultant crystal is in space group P1 and having unit cell dimensions of a=53.47 Å, b=58.67 Å, c=64.96 Å, α=88.41°, β=68.10° and y=85.52°, b) obtaining the three dimensional atomic coordinates and constructing a three-dimensional model for the c-Met kinase domain, c) utilizing the model to identify inhibitor of cMet activity.