Patent ID: 8900633

Claim:
A method of producing a product having a polymer matrix comprising the steps of: a) mixing a biodegradable polymer in powder form with an aqueous solution of a bone growth factor of the bone morphogenetic protein (BMP) class to form a slurry in such an amount that the aqueous solution is almost completely absorbed by the polymer in powder form, wherein the slurry comprises no supernatant liquid; wherein the biodegradable polymer has a particle size of less than or equal to 500 μm, and is selected from the group consisting of polylactic acid, polyglycolic acid, and copolymers thereof; wherein the aqueous solution has a concentration of 0.5 mg to 10 mg of bone growth factor per gram of biodegradable polymer in the product and wherein the pH-value of the aqueous solution is 4 to 5 or 9.5 to 10.5; b) drying the slurry obtained in step a); c) introducing the product from step b) into a shaping apparatus; and d) shaping the product introduced into the shaping apparatus into an application form for promoting cell growth, wherein the dried slurry is introduced into an autoclave as the shaping apparatus, subjected in the autoclave to pressure gassing with supercritical carbon dioxide above the glass transition temperature of the biodegradable polymer and below the decomposition temperature of the bone growth factor, and removed from the pressure-relieved autoclave as a product in foam form.