Patent ID: 7247471

Claim:
A roller bottle for use in culturing cells, comprising: a bottom; a top; and, a continuous side wall extending between said bottom and said top, said side wall having an interior surface and an exterior surface, and being spaced about a longitudinal axis of said bottle for allowing said bottle to rotate along said side wall about the longitudinal axis for distributing, along said side wall, a liquid medium contained in said bottle to wet said side wall, said side wall including at least one pleat extending from a first point proximate said top to a first point proximate said bottom, said pleat being arranged at an angle offset with respect to a plane perpendicular to the longitudinal axis of said bottle, said pleat defining at least one interior channel on said inner surface of said side wall for permitting laminar flow and distribution of said liquid along said pleat, said interior channel providing a surface for culturing the cells, wherein at least one smooth land is formed in said side wall, said land interrupting said pleat.