Patent ID: 6995260

Claim:
A compound of the formula wherein: Y 1 , Y 2 , Y 3 , and Y 4 , are independently on the ortho, meta or para position on the phenyl rings, and are independently hydrogen, alkyl, cycloalkyl, aryl, alkylaryl, arylalkyl, heteroaryl, or an alkyl, cycloalkyl, aryl, alkylaryl, arylalkyl, or heteroaryl group substituted with 1 to 4 hydrophilic groups selected from hydroxy, alkoxy, —C(O)OR 5 , —SOR 6 , —SO 2 R 6 , nitro, amido, ureido, carbamato, —SR 7 , —NR 8 R 9 , or poly-alkyleneoxide; or a substituent represented by the following formula: provided that at least four of (Y 1 ) a , (Y 2 ) b , (Y 3 ) c , and (Y 4 ) d are represented by formula (2); X is oxygen or sulfur; R 1 , R 2 , R 5 , R 6 , R 7 , R 8 , and R 9 are independently selected from hydrogen and C 1 to C 4 alkyl; Z is a carborane cluster comprising at least two carbon atoms and at least three boron atoms, or at least one carbon atom and at least five boron atoms, within a cage structure; r is 0 or an integer from 1 to 20; W 1 , W 1 , W 3 , and W 4 are hydrophilic groups independently selected from hydroxy, alkoxy, —C(O)OR 5 , —SOR 6 , —SO 2 R 6 , nitro, amido, ureido, carbamato, —SR 7 , —NR 8 R 9 , or polyalkylene oxide; a, b, c, and d independently represent an integer from 1 to 4; m, n, p, and q are independently 0 or an integer from 1 to 4; provided that at least one of m, n, p, and q is not zero, and each of the sums a+m, b+n, c+p, and d+q, independently represents an integer from 1 to 5; and M is either two hydrogen ions; a single monovalent metal ion; two monovalent metal ions; a divalent metal ion; a trivalent metal ion; a tetravalent metal ion; a pentavalent metal ion; a hexavalent metal ion; a radioactive metal ion useful in radioisotope-mediated radiation therapy or imageable by single photon emission computed tomography (SPECT) or positron emission tomography (PET); a paramagnetic metal ion detectable by magnetic resonance imaging (MRI); a metal ion suitable for boron neutron capture therapy (BNCT) or photodynamic therapy (PDT); or a combination thereof; wherein when M is a single monovalent metal ion, the compound is charge-balanced by a counter cation; and when M is a trivalent, tetravalent, pentavalent, or hexavalent metal ion, the compound is charge-balanced by an appropriate number of counter anions, dianions, or trianions.