Patent ID: 7151101

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: each of Q 1 and Q 2 is independently selected from 5–6 membered aromatic carbocyclic or heterocyclic ring systems, or 8–10 membered bicyclic ring systems wherein each ring of the bicyclic ring system is independently selected from an aromatic carbocyclic ring and an aromatic heterocyclic ring; wherein: Q 1 is substituted with 1 to 4 substituents, independently selected from halo; C 1 –C 3 alkyl optionally substituted with NR′ 2 , OR′, CO 2 R′ or CONR′ 2 ; O—(C 1 –C 3 )-alkyl optionally substituted with NR′ 2 , OR′, CO 2 R′ or CONR′ 2 ; NR′ 2 ; OCF 3 ; CF 3 ; NO 2 ; CO 2 R′; CONHR′; SR′; S(O 2 )N(R′) 2 ; SCF 3 ; CN; N(R′)C(O)R 4 ; N(R′)C(O)OR 4 ; N(R′)C(O)C(O)R 4 ; N(R′)S(O 2 )R 4 ; N(R′)R 4 ; N(R 4 ) 2 ; OR 4 ; OC(O)R 4 ; OP(O) 3 H 2 ; N═CH—N(R′) 2 ; —NHC(O)CH 2 -morpholine: —NHC(O)CH 2 -piperazine; —NHC(O)CH 2 -pyrrolidine; or —NHC(O)OCH 2 -pyridine; Q 2 is optionally substituted with up to 4 substituents, independently selected from halo; C 1 –C 3 straight or branched alkyl optionally substituted with NR′ 2 , OR′, CO 2 R′, S(O 2 )N(R′) 2 , N═CH—N(R′) 2 , R 3 , or CONR′ 2 ; O—(C 1 –C 3 )-alkyl optionally substituted with NR′ 2 , OR′, CO 2 R′, S(O 2 )N(R′) 2 , N═CH—N(R′) 2 , R 3 , or CONR′ 2 ; NR′ 2 ; OCF 3 ; CF 3 ; NO 2 ; CO 2 R′; CONHR′; R 3 ; OR 3 ; NHR 3 ; SR 3 ; C(O)R 3 ; C(O)N(R′)R 3 ; C(O)OR 3 ; SR′; S(O 2 )N(R′) 2 ; SCF 3 ; N═CH—N(R′) 2 ; or CN; R′ is selected from hydrogen; (C 1 –C 3 )-alkyl; (C 2 –C 3 )-alkenyl or alkynyl; phenyl or phenyl substituted with 1 to 3 substituents independently selected from halo, methoxy, cyano, nitro, amino, hydroxy, methyl or ethyl; R 3 is selected from a 5–6 membered aromatic carbocyclic or heterocyclic ring system; R 4 is (C 1 –C 4 )-alkyl optionally substituted with N(R′) 2 , OR′, CO 2 R′, CON(R′) 2 , or SO 2 N(R 2 ) 2 ; or a 5–6 membered carbocyclic or heterocyclic ring system optionally substituted with N(R′) 2 , OR′, CO 2 R′, CON(R′) 2 , or SO 2 N(R 2 ) 2 ; X is selected from —S—, —O—, —S(O 2 )—, —S(O)—, —S(O 2 )—N(R 2 )—, —N(R 2 )—S(O 2 )—, —N(R 2 )—C(O)O—, —O—C(O)—N(R 2 )—, —C(O)—, —C(O)O—, —O—C(O)—, —C(O)—N(R 2 )—, —N(R 2 )—, C(R 2 ) 2 —, or —C(OR 2 ) 2 —; R 2 is selected from hydrogen, (C 1 –C 3 )-alkyl, or (C 1 –C 3 )-alkenyl; wherein each (C 1 –C 3 )-alkyl or (C 1 –C 3 )-alkenyl is optionally substituted with —N(R′) 2 , —OR′, SR′, —C(O)—N(R′) 2 , —S(O 2 )—N(R′) 2 , —C(O)—OR′, or R 3 ; and R′ is selected from hydrogen, (C 1 –C 3 )-alkyl, OH, or O—(C 1 –C 3 )-alkyl.