Patent ID: 8030340

Claim:
A compound of formula (I): wherein: A is C 1-10 alkyl, C 5-10 aryl, C 5-10 arylC 1-6 alkyl, C 5-10 heteroaryl, C 5-10 heteroarylC 1-6 alkyl, C 5-10 arylC 1-6 alkoxy, C 1-10 haloalkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, C 1-6 alkylOC(O)C 1-6 alkyl, C 1-6 alkylC(O)OC 1-6 alkyl, C 5-10 aryloxyC 1-10 alkyl or NR 5 R 6 C 0-6 alkyl whereby the aryl is optionally substituted with one or more substituents selected from B; R 1 and R 1a are independently selected from hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl and C 1-4 alkylOC 1-4 alkyl; R 2 is hydrogen or C 1-4 alkyl; R 3 is C 5-10 arylC 0-3 alkyl, C 5-10 arylOC 0-3 alkyl, or C 5-10 heteroarylC 0-3 alkyl, each of which is optionally substituted by one or more B; B is C 0-3 hydroxyalkyl, C 1-4 alkyl, C 1-4 alkoxy, C 0-4 alkylthioC 0-4 alkyl, C 3-6 cycloalkylC 0-4 thioalkyl, C 0-3 alkylS(O) n C 0-4 alkyl, C 1-6 haloalkyl, C 1-4 haloalkoxy, halogen, nitro, cyano, C 1-4 alkylOC 1-6 alkyl, C 0-6 alkylOC 1-4 alkylOC 0-4 alkyl, C 0-6 alkylC(O)C 0-6 alkyl, C 0-4 alkylC(O)OC 0-4 alkyl, C 0-4 alkylOC(O)C 0-4 alkyl, NR 5 R 6 C 0-4 alkyl, NR 5 R 6 C(O)C 0-4 alkyl, NR 5 R 6 OC(O)C 0-4 alkyl, NR 5 R 6 C(O)OC 0-4 alkyl, R 6 C(O)R 5 NC 1-4 alkyl, C 0-4 alkylOC(O)C 0-4 alkylNH, C 0-4 alkylC(O)OC 0-4 alkylNH, C 0-4 alkylC(O)C 0-4 alkylNH or NR 5 R 6 S(O) n C 0-4 alkyl; R 4 is hydrogen, hydroxy, halogen, C 1-4 alkyl or C 1-4 haloalkyl; W is hydrogen, C 3-7 cycloalkyl, C 1-4 alkyl, phenyl, thienyl, isoxazolyl, pyrazolyl, pyridinyl or pyrimidinyl all of optionally substituted with one or more substituents selected from halogen, C 0-3 hydroxyalkyl, C 1-4 alkyl, C 1-4 alkoxy, C 0-4 alkylthioC 0-4 alkyl, C 3-6 cycloalkylC 0-4 thioalkyl, C 0-4 alkylS(O) n C 0-4 alkyl, C 1-6 haloalkyl, C 1-4 haloalkoxy, halo, nitro, cyano, C 1-4 alkylOC 1-6 alkyl, C 1-6 alkylOC 1-6 alkylOC 1-6 alkyl, C 0-6 alkylC(O)C 0-6 alkyl, C 0-4 alkylC(O)OC 0-4 alkyl, C 1-4 alkylOC(O)C 0-4 alkyl, NR 5 R 6 C 0-4 alkyl, NR 5 R 6 C(O)C 0-4 alkyl, NR 5 R 6 C(O)OC 0-4 alkyl, NR 5 R 6 OC(O)C 0-4 alkyl, R 6 C(O)R 5 NC 0-4 alkyl, C 0-4 alkylOC(O)C 0-4 alkylNH, C 0-4 alkylC(O)C 0-4 alkylNH and NR 5 R 6 S(O) n C 0-4 alkyl; X is CH 2 , O, S, S(O), S(O) 2 or NH; Y is hydrogen, halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 thioalkyl, C 1-4 haloalkyl, C 1-4 alkoxyhalo, nitro, cyano, hydroxy, R 5 C(O), R 5 OC(O), R 5 C(O)O, S(O) n C 1-4 alkyl, R 5 R 6 NS(O) n , benzyloxy, imidazolyl, C 1-4 alkylNHC(O), NR 5 R 6 C(O), C 1-4 alkylC(O)NH or NR 5 R 6 ; R 5 and R 6 are independently selected from hydrogen, C 1-4 alkyl and C 3-7 cycloalkyl, or R 5 and R 6 form together a group (O)C 5-10 arylC(O)—; and n is 1 or 2, or a pharmaceutically acceptable salt thereof.