Patent ID: 7166733

Claim:
An amidomalonate N,O—Pt complex having the chemical structure: wherein: X is C═O or SO 2 ; R 1 is selected from the group consisting of an aliphatic group, a water-solubilizing group, a tumor-targeting group and a water-solubilizing group further comprising one or more tumor-targeting group(s); q is 0 or 1; r is 2–500; [Linker] is selected from the group consisting of an alkyl group, an amino acid, a polyaminoacid, a polyethyleneglycol (PEG) and any combination of thereof; R 2 and R 3 are independently selected from the group consisting of NH 3 , a primary amine, a secondary amine, a tertiary amine and a nitrogen-containing heteroalicyclic; or, R 2 and R 3 are independently primary, secondary or tertiary amino groups, both of which are covalently bonded to carbon atoms of an aliphatic, an alicyclic, an aromatic, an aralkyl or a heterocyclic group wherein, when the amino group nitrogen atoms form a chelate with the Pt atom, a 5–7 member ring results; R 4 is selected from the group consisting of hydrogen, a cation and an ester-forming group, wherein, the complex is obtained essentially pure by a process comprising contacting a corresponding amidomalonate O,O′—Pt complex or a mixture of amidomalonate O,O′—Pt and N,O—Pt complexes with an aqueous solution having a pH of 6.0 to 10.0.