Patent ID: 7291621

Claim:
A compound of Formula VIII: or a pharmaceutically acceptable salt thereof, wherein: R is (i) halogen, hydroxy, C 1 -C 3 haloalkyl, or C 1 -C 3 haloalkoxy, or (ii) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, mono- or di-(C 1 -C 6 alkyl)amino, or C 3 -C 7 cycloalkyl(C 0 -C 4 alkyl), each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, amino, oxo, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and mono- and di(C 1 -C 4 )alkylamino, or (iii) phenyl, or (iv) a heterocyclic ring, having from 4 to 8 ring atoms, and 1 to 3 heteroatoms independently selected from N, O, and S; wherein each of (iii) and (iv) is substituted with from 0 to 3 substituents independently chosen from hydroxy, halogen, amino, cyano, nitro, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, mono- and di-C 1 -C 6 alkylamino, mono- and di-C 1 -C 6 alkylaminoC 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, C 1 -C 2 alkylthio, and —NHC(═O)C 1 -C 2 alkyl; R 2 is benzyl or indanyl; each of which is substituted with from 0 to 3 groups independently selected from halogen, hydroxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, COOH, —NC(═O)C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 3 and R 4 are hydrogen; R 5 and R 6 each represent 0 or more substituents independently chosen from halogen, hydroxy, cyano, nitro, amino, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, mono- and di-(C 1 -C 6 )alkylamino, C 1 -C 3 haloalkyl, C 1 -C 3 haloalkoxy, C 1 -C 2 alkylthio, and —NHC(═O) C 1 -C 2 alkyl; Ar 2 represents phenyl substituted with from 0 to 5 substituents independently selected from a) halogen, hydroxy, cyano, amino, —COOH, —CONH 2 , C 1 -C 3 haloalkyl, and C 1 -C 3 haloalkoxy, b) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, mono- and di-(C 1 -C 6 alkyl)amino, and (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, each of which is substituted with from 0 to 5 substituents independently chosen from halogen, hydroxy, amino, oxo, cyano, —COOH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di(C 1 -C 4 )alkylamino, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, C 1 -C 4 alkylcarboxamide, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulfonate, C 2 -C 4 alkylester, and C 1 -C 4 alkoxycarbonyl, c) C 1 -C 4 alkylcarboxamide, C 1 -C 4 alkanoyl, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulfonate, C 2 -C 4 alkylester, C 1 -C 4 alkoxycarbonyl, and heterocycloalkyl(C 0 -C 4 alkyl), and d) (heterocycle)C 0 -C 4 alkyl, having 1 or 2 rings, 3 to 8 atoms in each ring, and 1 to 3 heteroatoms independently selected from N, O, and S, substituted with from 0 to 3 groups independently chosen from halogen, hydroxy, nitro, amino, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and 5- to 7-membered heterocycloalkyl substituents.