Patent ID: 6861418

Claim:
A compound of the formula 1: wherein: R 1 is an aryl or heteroaryl substituent, optionally substituted by one or more substituent selected from the group consisting of halogen, —OR 6 , —COR 6 , —COOR 6 , OCOR 6 , —CONR 6 R 7 , —R 6 NCOR 7 , —NR 6 R 7 , —CN, —NO 2 , —CX 3 , —SO 2 R 6 , —SO 2 OR 6 , —SO 2 NR 6 R 7 , —R 6 NSO 2 R 7 , perfluoroalkyl, lower alkyl, lower alkyl further substituted by one or more of R 2 , lower alkenyl, lower alkenyl further substituted by one or more of R 2 , lower alkynyl, lower alkynyl further substituted by one or more of R 2 , cycloalkyl, cycloalkyl further substituted by one or more of R 2 , heterocycle, heterocycle further substituted by one or more of R 2 , aryl and aryl further substituted by one or more of R 2 ; R 2 is selected from the group consisting of hydrogen, halogen, —OR 6 , —COR 6 , —COOR 6 , OCOR 6 , —CONR 6 R 7 , —R 6 NCOR 7 , —NR 6 R 7 , —CN, —NO 2 , —CX 3 , —SO 2 R 6 , —SO 2 R 6 , —SO 2 NR 6 R 7 , —R 6 NSO 2 R 7 , perfluoroalkyl, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, heterocycle and aryl; R 3 is selected from the group consisting of hydrogen, halogen, —OR 6 , —COR 6 , —COOR 6 , OCOR 6 , —CONR 6 R 7 , —R 6 NCOR 7 , —NR 6 R 7 , —CN, —NO 2 , —CX 3 , —SO 2 R 6 , —SO 2 OR 6 , —SO 2 NR 6 R 7 , —R 6 NSO 2 R 7 , perfluoroalkyl, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, heterocycle and aryl; R 4 is selected from the group consisting of hydrogen, halogen, —OR 6 , —COR 6 , —COOR 6 , OCOR 6 , —CONR 6 R 7 , —R 6 NCOR 7 , —NR 6 R 7 , —CN, —NO 2 , —CX 3 , —SO 2 R 6 , —SO 2 OR 6 , —SO 2 NR 6 R 7 , —R 6 NSO 2 R 7 , perfluoroalkyl, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, heterocycle and aryl; R 5 is selected from the group consisting of hydrogen, halogen, —OR 6 , —COR 6 , —COOR 6 , OCOR 6 , —CONR 6 R 7 , —R 6 NCOR 7 , —NR 6 R 7 , —CN, —NO 2 , —CX 3 , —SO 2 R 6 , —SO 2 OR 6 , —SO 2 NR 6 R 7 , —R 6 NSO 2 R 7 , perfluoroalkyl, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, heterocycle and aryl; provided that no more than one of R 3 , R 4 , or R 5 is hydrogen; R 3 and R 4 or R 4 and R 5 may be linked together to form a 4-, 5-, 6- or 7-membered rind optionally containing one or more heteroatoms selected from the group consisting of O, N, S, SO and SO 2 , which ring may contain 1 or 2 double bonds and may be further substituted by one or more of —(CH 2 ) n —NR 6 R 7 , —CH 2 ) n —CR 6 R 7 , —(CH 2 ,) n —C(O)—(CH 2 ) n —NR 6 R 7 , —(CH 2 ) n SO 2 R 6 R 7 , —(CH 2 ) n NSO 2 R 6 R 7 or —CH 2 ) n —C(O)—R 6 , wherein n is 0-4; R 6 and R 7 is selected from the group consisting of hydrogen, halogen, —OR 2 , —CX 3 , perfluoroalkyl, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, heterocycle and aryl; X is fluorine, chlorine, bromine or iodine; and or a pharmaceutically acceptable salt thereof.