Patent ID: 6909029

Claim:
A method for identifying at least one test substance that is an antagonist of a human 7 transmembrane receptor (h7TMR), said method comprising the steps of: (a) providing at least one transgenic C. elegans whose genome comprises a nucleotide sequence encoding a h7TMR, wherein said h7TMR is expressed in sensory neurons of said transgenic C. elegans , and wherein said sensory neurons correlate with behavior, and wherein said transgenic C. elegans exhibits a phenotype; (b) contacting said at least one transgenic C. elegans with at least one test substance, wherein said at least one test substance is distributed in a medium; (c) determining whether said at least one test substance causes a suppression of said phenotype in said at least one transgenic C. elegans ; and (d) identifying said at least one test substance that causes a suppression of said phenotype in said at least one transgenic C. elegans as an antagonist of said 7TMR.