Patent ID: 8785632

Claim:
An enantiomerically pure compound of formula 1 wherein: Y is CR 12 ; R 1 is 5-12 membered heteroaryl; and each hydrogen in R 1 is optionally replaced by one or more R 3 groups; R 2 is hydrogen; each R 3 is independently halogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 3-12 cycloalkyl, C 6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, —S(O) m R 4 , —SO 2 NR 4 R 5 , —S(O) 2 OR 4 , —NO 2 , —NR 4 R 5 , —(CR 6 R 7 ) n OR 4 , —CN, —C(O)R 4 , —OC(O)R 4 , —O(CR 6 R 7 ) n R 4 , —NR 4 C(O)R 5 , —(CR 6 R 7 ) n C(O)OR 4 , —(CR 6 R 7 ) n C(O)NR 4 R 5 , —(CR 6 R 7 ) n NCR 4 R 5 , —C(═NR 6 )NR 4 R 5 , —NR 4 C(O)NR 5 R 6 , or —NR 4 S(O) p R 5 , each hydrogen in R 3 is optionally replaced by R 8 , and R 3 groups on adjacent atoms may combine to form a C 6-12 aryl, 5-12 membered heteroaryl, C 3-12 cycloalkyl or 3-12 membered heteroalicyclic group; each R 4 , R 5 , R 6 and R 7 is independently hydrogen, halogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 3-12 cycloalkyl, C 6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl; or any two of R 4 , R 5 , R 6 and R 7 bound to the same nitrogen atom may, together with the nitrogen to which they are bound, be combined to form a 3 to 12 membered heteroalicyclic or 5-12 membered heteroaryl group optionally containing 1 to 3 additional heteroatoms selected from N, O, and S; or any two of R 4 , R 5 , R 6 and R 7 bound to the same carbon atom may be combined to form a C 3-12 cycloalkyl, C 6-12 aryl, 3-12 membered heteroalicyclic or 5-12 membered heteroaryl group; and each hydrogen in R 4 , R 5 , R 6 and R 7 is optionally replaced by R 8 ; each R 8 is independently halogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 3-12 cycloalkyl, C 6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, —NH 2 , —CN, —OH, —O—C 1-12 alkyl, —O—(CH 2 ) n C 3-12 cycloalkyl, —O—(CH 2 ) n C 6-12 aryl, —O—(CH 2 ) n (3-12 membered heteroalicyclic) or —O—(CH 2 ) n (5-12 membered heteroaryl); and each hydrogen in R 8 is optionally replaced by R 11 ; each R 11 is independently halogen, C 1-12 alkyl, C 3-12 cycloalkyl, C 6-12 aryl, 3-12 membered heteroalicyclic, 5-12 membered heteroaryl, —O—C 1-12 alkyl, —O—(CH 2 ) n C 3-12 cycloalkyl, —O—(CH 2 ) n C 6-12 aryl, —O—(CH 2 ) n (3-12 membered heteroalicyclic), —O—(CH 2 ) n (5-12 membered heteroaryl) or —CN, and each hydrogen in R 11 is optionally substituted by halogen, —OH, —CN, —C 1-12 alkyl which may be partially or fully halogenated, or —O—C 1-12 alkyl which may be partially or fully halogenated; R 12 is hydrogen; each m is independently 0, 1 or 2; each n is independently 0, 1, 2, 3 or 4; and each p is independently 1 or 2; or a pharmaceutically acceptable salt thereof.