Patent ID: 8703767

Claim:
A compound having a structure represented by a formula: wherein R 1 is halogen or NR 8 Ar 1 , or R 1 and R 2 are covalently bonded and, together with the intermediate carbons, comprise an optionally substituted fused five-membered or six-membered C2-C5 heterocyclic ring; wherein R 8 is selected from hydrogen and C1-C6 alkyl; wherein Ar 1 is phenyl substituted with 0-3 groups independently selected from cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, SO 2 R 9 , C1-C3 alkylamine, and C1-C3 dialkylamino or Ar 1 is monocyclic heteroaryl substituted with 0-3 groups independently selected from halo, cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, SO 2 R 9 , C1-C3 alkylamine, and C1-C3 dialkylamino; wherein R 9 is selected from hydrogen and C1-C6 alkyl; wherein R 2 is hydrogen, or R 1 and R 2 are covalently bonded and, together with the intermediate carbons, comprise an optionally substituted fused five-membered or six-membered C2-C5 heterocyclic ring; wherein R 3 is hydrogen, halogen, C1-C6 alkyl, or a group having a structure represented by the formula: wherein R 10 is selected from hydrogen and C1-C6 alkyl; wherein each of R 11a and R 11b is independently selected from hydrogen, halogen, and C1-C6 alkyl; wherein each of R 12a and R 12b is independently selected from hydrogen, halogen, and C1-C6 alkyl; and wherein R 13 is a five-membered or six-membered C3-C6 heterocycle substituted with 0-3 groups selected from halogen, cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, and C1-C6 polyhaloalkyl; wherein each of R 4a , R 4b , R 4c , and R 4d is independently selected from hydrogen, halogen, and C1-C6 alkyl; wherein R 5 is selected from hydrogen and C1-C6 alkyl; wherein R 6 is selected from hydrogen and C1-C6 alkyl; and wherein each of R 7a and R 7b is independently selected from hydrogen and C1-C6 alkyl, or a pharmaceutically acceptable salt, hydrate, solvate, or polymorph thereof.