Patent ID: 8491790

Claim:
A method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, in an organic solution suitable for a subsequent radiolabelling reaction, said method comprising the following steps of: passing said aqueous [18F] fluoride solution through a solid phase extraction column containing an anion-exchange resin so that said [18F] fluorides are trapped on said resin; eluting said [18F] fluorides with an eluting solution to release said [18F] fluorides from said anion-exchange resin under a form which is reactive and immediately usable for a labelling reaction; using the eluted solution for a radiolabelling reaction; wherein the eluting solution is an organic solution with water content <3%, containing at least the following components: a polar aprotic organic solvent; a first compound (A) which is a molecule containing at least one acidic hydrogen; and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of the first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).