Patent ID: 7777070

Claim:
A method of synthesizing a compound of Formula (II) comprising: reacting trans-4-(aminomethyl)-cyclohexanecarboxylic acid and a silylation reagent to provide an intermediate; and reacting the intermediate and a compound of Formula (IX) to provide a compound of Formula (II), wherein: X is selected from fluoro, chloro, bromo, and iodo; Z is selected from a halide, p-nitrophenolate, and imidazolyl; R 2 and R 3 are independently selected from hydrogen, alkyl, substituted alkyl, alkoxycarbonyl, substituted alkoxycarbonyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, carbamoyl, substituted carbamoyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl, or R 2 and R 3 together with the carbon atom to which they are bonded form a cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, or substituted cycloheteroalkyl ring; and R 4 is selected from aryldialkylsilyl, substituted aryldialkylsilyl, trialkylsilyl, and substituted trialkylsilyl.