Patent ID: 7449582

Claim:
A compound of Formula I: in which: n is 0 ,1 or 2; Y is selected from —C(H)═ and —N═; Z is selected from —C(H)═ and —N═; R 1 is selected from hydrogen, halo and —R 4 ; R 2 is selected from hydrogen and C 1-6 alkyl; R 3 is selected from halo, nitro, C 1-6 alkyl and C 1-6 alkoxy; R 4 is selected from C 3-8 heterocycloalkyl, —XNR 5 R 6 , —XNR 5 C(O)R 6 , —XC(O)NR 5 R 6 and —XNR 5 S(O) 0-2 R 6 ; wherein X is a bond or C 1-4 alkylene; R 5 is selected from hydrogen and C 1-6 alkyl; R 6 is selected from C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein any aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R 4 is optionally substituted by 1 to 3 radicals independently selected from halo, hydroxy, nitro, cyano, C 1-6 alkyl optionally substituted with hydroxy, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XOXNR 7 R 8 , —XS(O) 0-2 R 7 , —XS(O) 0-2 NR 7 R 8 , —XOR 7 , —XC(O)NR 7 R 8 , —XNR 7 R 8 , —XNR 7 S(O) 0-2 R 7 and —XR 9 ; wherein X is a bond or C 1-4 alkylene; R 7 and R 8 are independently selected from hydrogen and C 1-6 alkyl; R 9 is selected from C 6-10 aryl, C 5-10 heteroaryl C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 9 is optionally substituted with 1 to 3 C 1-6 alkyl radicals; R 10 is selected from hydrogen, halo and C 1-6 alkyl; and the pharmaceutically acceptable salts, solvates and isomers thereof.