Patent ID: 8410078

Claim:
A method of treating a mammalian subject in need of treatment for a cardiac or vascular disease or condition responsive to activation of the cardiac P2X receptor, comprising administering an effective amount of an N-methanocarba derivative of AMP that activates a cardiac P2X receptor for the treatment of the cardiac or vascular disease or condition responsive to activation of the cardiac P2X receptor, wherein the N-methanocarba derivative of AMP that activates the cardiac P2X receptor is of the formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, alkyl, alkoxy, amino, mono- or di-alkylamino, mono or bicyclic cycloalkyl, cycloalkyloxy, aryl, arylalkyl, acyl, sulfonyl, arylsulfonyl, or a mono- or bicyclic thiazolyl group; and R 2 is hydrogen, halogen, thiol, cyano, alkyl, alkenyl, alkynyl, alkylthio, alkylsulfinyl, alkylsulfonyl, aryl, arylamino, or aryloxy; R 3 is hydrogen, halogen, methyl, or ethyl; and R 4 and R 5 are independently hydrogen, methyl, or methoxy, wherein the cardiac or vascular disease or condition responsive to activation of the cardiac P2X receptor is a post-myocardial infarction condition, or diastolic heart failure.