Patent ID: 7977114

Claim:
An apparatus for monitoring processes for the presence or absence of one or more compounds of interest in dissolution samples by liquid chromatography, comprising: a. a dissolution assembly for receiving dosage forms capable of dissolution and subjecting such dosage forms to conditions for dissolution during a dissolution period and forming a dissolution fluid which changes concentration of the one or more compounds of interest during said dissolution period; b. an autosampler in communication with said dissolution assembly for withdrawing aliquots of said dissolution fluid at different times to form one or more samples corresponding to the degree of dissolution of the dosage form during the dissolution period; c. a pump for receiving and propelling one or more samples in a fluid path; d. a valve element in fluid communication with said pump for receiving said samples from said pump and directing said sample along one fluid path selected from the group consisting of a first fluid path and a second fluid path; e. said first fluid path comprising a delay path comprising a delay volume wherein said delay path comprises a knitted reaction coil to reduce bandspreading; f. said second fluid path comprising a chromatography assembly having at least on chromatography column; and g. at least one detector in fluid communication with said delay path and said chromatography assembly for detecting the one or more compounds of interest to allow said at least one detector to receive samples from said two fluid paths.