Patent ID: 6916805

Claim:
A compound according to Formula I or stereoisomers or pharmaceutically acceptable salts, esters, or amides thereof, wherein: A is selected from NCH 2 , N(alkyl)CH 2 , CH 2 N, CH 2 N(alkyl); B is selected from (C 3 -20)alkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heteroalkylalkyl, aryl, arylalkyl, heterocycle, heterocycloalkyl, each optionally substituted with R1 and R2; D is selected from H, (C3-20)alkyl, cycloalkyl, heteroallkyl, cycloalkylalkyl, heteroalkylalkyl, aryl, arylalkyl, heterocycle, heterocycloalkyl, each optionally substituted with R1 and R2; E is absent or selected from O; F is N; G is selected from alkyl, alkyl interrupted by one or more heteroatoms, cycloalkyl, cycloalkyl interrupted by one or more heteroatoms; J is selected from aryl or heterocycle each optionally substituted with R 1 and R 2 ; K is absent or selected from an alkyl, alkyl interrupted by one or more heteroatoms, cycloalkyl interrupted by one or more heteroatoms, cycloalkylalkyl interrupted by one or more heteroatoms, each optionally substituted with R 1 and R 2 ; L is selected from H, chlorine, fluorine, bromine, iodine, OH, O(alkyl), amine, alkyl, fluoroalkyl, amide, NO 2 , SH, S(O) n (alkyl), SO 3 H, SO 3 alkyl, aldehyde, ketone, acid, ester, urea, Oalkylamide, Oalkylester, Oalkylacid, Nalkylacid, alkylamine, alkylamide, alkylketone, alkylacid, alkylester, alkylurea, Nalkylamide, Nalkylester, NC(═O)alkyl, NC(═O)aryl, NC(═O)cycloalkyl, NC(═O)cycloalkylalkyl, NC(═O)alkylaryl, R 1 , R 2 , nitrile; R 1 is selected from H, amine, alkylamine, amide, C(═NH)NHNH 2 , alkylC(═NH)NHNH 2 , C(═NH)NHOH, alkylC(═NH)NHOH, NHC(═NH)NH 2 , alkylNHC(═NH)NH 2 , C(═S)NH 2 , alkylC(═S)NH 2 , C(═NH)alkyl, alkylC(═NH)alkyl, C(═NR 3 )N(R 4 )(R 5 ), alkyC(═NR 3 )N(R 4 )(R 5 ); R 2 is selected from H, chlorine, fluorine, bromine, iodine, OH, Oalkyl, amine, alkylaldehyde, alkylamide, alkylester, alkylketone, alkylacid, Oalkylamide, Oalkylacid, Oalkylester, aminealkylacid, aminealkylamide, aminealkylester, NC(═O)alkyl, NC(═O)aryl, NC(═O)cycloalkyl, NC(═O)alkylaryl, alkylamine, amide, aldehyde, ester, ketone, NO 2 , SH, S(O) n (C 1-10 alkyl), SO 3 H, SO 3 alkyl, CHO, acid, alkyl, C(═NH)alkyl, C(═NH)NHNH 2 , alkylC(═NH)NHNH 2 , C(═NH)NHOH, alkylC(═NH)NHOH, NHC(═NH)NH 2 , alkylNHC(═NH)NH 2 , C(═S)NH 2 , alkylC(═S)NH 2 , alkylC(═NH)alkyl, C(═NR 3 )N(R 4 )(R 5 ), alkylC(═NR 3 )N(R 4 )(R 5 ); R 3 , R 4 and R 5 are a hydrogen atom, alkyl group having 1 to 4 carbon atoms optionally interrupted by a heteroatom, or R 4 and R 5 are bonded to form —(C 2 ) p —W—(CH 2 ) q —, wherein p and q are an integer of 2 or 3, a certain position on the methylene chain is unsubstituted or substituted by an alkyl group having 1 to 4 carbon atoms, W is a direct bond, —CH 2 —, —O—, —N(R 6 )—, or —S(O) r — wherein R 6 is H or alkyl, and r is 0 or 1 or 2; n is selected from 0, 1, 2; X 1 is C; X 2 is C; X 3 is C; X 4 is C; and — represents an optional additional bond when A is N.