Patent ID: 6841358

Claim:
A recombinant DNA encoding an; immunogenic fusion protein, wherein said recombinant DNA comprises a sequence (1) coding for a polypeptide heterologous with respect to a filamentous hemagglutinin of Bordetella (Fha) fused in the same reading frame with a sequence (2) placed upstream from said sequence (1), said sequence (2) coding for at least a part of the precursor of the Fha, this part comprising the site of interaction of the Fha with heparin, said sequence (2) being placed under the control of a promoter recognized by the polymerases of a cell transformed with said recombinant DNA and when introduced into a cell culture is expressed in said cell culture or exposed at the surface of cells, wherein said recombinant DNA is expressed as an immunogenic translational fusion protein.