Patent ID: 7815939

Claim:
Drug containing coated microparticles having an average particle diameter of 350 μm or less, for quickly disintegrating preparations in the oral cavity, wherein microparticles containing the drug solifenacin or a salt thereof and polyethylene glycol which are present in a homogeneously mixed state are coated with a film comprising a water-soluble polymer, said water-soluble polymer selected from the group consisting of hydroxypropylmethylcellulose, hydroxypropylcellulose, methyl cellulose and a mixture thereof, and are further coated with an outer film comprising: (1) a pH-independent water-insoluble polymer accounting for 60% or more and less than 79% of the film, wherein the pH-independent water-insoluble polymer is ethyl cellulose; and (2) hydroxypropylcellulose accounting for more than 21% and 40% or less of the film, wherein the rate of dissolution of drug from the drug-containing coated microparticles using a test liquid simulating inside of the oral cavity is from 0% to 25% in 3 minutes.