Patent ID: 7932240

Claim:
A compound of Formula IV′: or a single enantiomer, a mixture of an enantiomeric pair, an individual diastereomer, a mixture of diastereomers, or any tautomeric form thereof; or a pharmaceutically acceptable salt or prodrug thereof, wherein: R 1 is H, alkyl, arylalkyl, heteroarylalkyl, —NR 10 SO 2 R 8 , —OR 8 , —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , aryl, alkenyl, alkynyl, heterocyclylalkyl, sulfonyl, or heteroaryl; R 4 is H, alkyl, aryl-CH 2 —, —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , sulfonyl, aryl, arylalkyl, alkenyl, alkynyl, heterocyclylalkyl or heteroaryl; R 4′ is H, alkyl, aryl-CH 2 —, —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , sulfonyl, aryl, arylalkyl, alkenyl, alkynyl, heterocyclylalkyl or heteroaryl; R 5 is H, halogen, —NR 10 SO 2 R 8 , —OR 8 , —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , alkyl, aryl, or heteroaryl, or R 4 and R 5 together form a part of a 3-8 membered heterocycloalkyl ring; R 6 is H, halogen, —NR 10 SO 2 R 8 , —OR 8 , —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , alkyl, aryl, or heteroaryl, or R 5 and R 6 together form a part of a 3-8 membered cycloalkyl or heterocycloalkyl ring; R 5′ is H, halogen, cyano, nitro, —NR 10 SO 2 R 8 , —OR 8 , —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , alkyl, aryl, heteroaryl, —NR 8 R 10 , alkenyl, or alkynl; R 6′ is H, halogen, cyano, nitro, —NR 10 SO 2 R 8 , —OR 8 , —NR 8 R 9 , —C(O)R 8 , —C(O)NR 8 R 9 , —C(O)OR 8 , alkyl, aryl, or heteroaryl, or R 5′ and R 6′ together form a part of a 3-8 membered, aryl ring; R 12 is F, —OR 8 , —SR 8 , —NR 8 R 9 , alkyl, or aryl; each R 8 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-14 aryl, heteroaryl, heterocyclyl, C 1-6 alkyl-C 3-7 cycloalkylene, or C 1-10 alkyl-siloxyl; each R 9 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-14 aryl, heteroaryl, or heterocyclyl; or R 8 and R 9 together with the N atom to which they are attached form heterocyclyl; each R 10 is independently H, alkyl, aryl, sulfonyl, C(O)R 8 , C(O)OR 8 or C(O)NR 8 R 9 ; and each Y is independently O or S, wherein each alkyl, aryl, arylalkyl, heteroaryl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, sulfonyl, or alkyl-cycloalkyl is optionally substituted.