Patent ID: 8476314

Claim:
A method for treatment of pain in a subject in need thereof comprising a step of modulating a slow sodium channel signaling pathway involving ligand-receptor binding in the opioid or opioid-like receptor site area and a tetrodotoxin-resistant slow sodium channel known as NaV1.8, wherein said step is performed by in-vivo administration of a substance comprising a pharmaceutically acceptable carrier and a gamma-pyrone, said gamma-pyrone having a molecule with a carboxy group in position 2 of the pyranone ring and a carbonyl group in position 4 of the pyranone ring, said gamma-pyrone molecule further having a substituent in position 5 capable of participating in Ca2+ chelation, said substance is administered in a dosage containing from about 0.05 mg to about 100 mg of said gamma-pyrone.