Patent ID: 8030487

Claim:
A compound of structure A: wherein: G 1 is selected from a group consisting of an optionally substituted aryl or an optionally substituted heteroaryl; the moiety L 1 -L 2 is selected from a group consisting of: A 1 is selected from a group consisting of a bond, NR a , C(O), S(O), S(O) 2 , P(O) 2 , O, S, and C(R a ) 2 , wherein if A 1 is a bond, then the phenyl ring is directly connected to the group A 2 ; A 2 is selected from a group consisting of NR, C(O), S(O), S(O) 2 , P(O) 2 , O, and S; and the connectivity between the phenyl ring, A 1 , A 2 and the pyrimidine ring are chemically correct; R a is selected from a group consisting of H, lower alkyl, branched alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, alkylhydroxyl, alklythiol, and alkylamino; R 3 is selected independently for each occurrence from a group consisting of hydrogen, alkyl, branched alkyl, alkoxy, halogen, CF 3 , cyano, substituted alkyl, hydroxyl, alkylhydroxyl, thiol, alkylthiol, thioalkyl, amino, and aminoalkyl; n is an integer having value between 0 and 4 inclusive; the moiety is selected from a group consisting of: L 5 is selected from a group consisting of lower alkyl, branched alkyl, CF 3 , cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, bicyclic aryl, bicyclic heteroaryl, bicyclic with one of the rings being aryl or heteroaryl and the other ring being nonaryl, and bicyclic with both rings being nonaryl; wherein an optionally substituted aryl or heteroaryl, independently for each occurrence, can be substituted on 1, 2, 3, or 4 carbons by alkyl, branched alkyl, alkoxy, halogen, CF 3 , cyano, substituted alkyl, hydroxyl, alkylhydroxyl, thiol, alkylthiol, thioalkyl, amino, and aminoalkyl; or a pharmaceutically acceptable salt or stereoisomer thereof.