Patent ID: 7291599

Claim:
A method for the reduction of neurodegenerative lesions caused by the formation of aggregates of mis-folded proteins and for the control and/or modulation of inflammation accelerating such lesions comprising the step of administering to a patient in need thereof an effective amount of a composition comprising: a) an inhibitor of dipeptidyl peptidase IV (DP IV) and/or at least one inhibitor of enzymes having a similar substrate specificity (DP IV-analogous enzymatic activity), in combination with: b) an inhibitor of alanylaminopeptidase (aminopeptidase N; APN) and/or at least one inhibitor of enzymes having a similar substrate specificity (APN-analogous enzymatic activity); wherein the neurodegenerative lesions are reduced, and wherein the reduction of neurodegenerative lesions is greater than the additive effect of administering the DP IV inhibitor alone or the APN inhibitor alone.