Patent ID: 8318202

Claim:
A pharmaceutical composition comprising: a first layer comprising from 750 mg to 850 mg ibuprofen as an active pharmaceutical ingredient and at least one excipient, and a second layer comprising from 24 mg to 28 mg famotidine as an active pharmaceutical ingredient and at least one excipient, wherein the active pharmaceutical ingredients are in direct contact, wherein the pharmaceutical composition is in the form of a tablet, provided that if the pharmaceutical composition is a tablet-in-tablet formulation, the first layer completely surrounds the second layer, wherein the pharmaceutical composition is formulated for immediate release, and wherein none of the pharmaceutical composition, the first layer, the second layer, the famotidine, or the ibuprofen is enterically coated or formulated for sustained or delayed release, wherein the pharmaceutical composition is formulated so that release of the ibuprofen active pharmaceutical ingredient and the famotidine active pharmaceutical ingredient begins to occur at about the same time, wherein the famotidine is not present as barrier coated famotidine multiparticulates dispersed in an ibuprofen matrix, and wherein no more than about 1% of a sulfamide is present when the composition is stored at 40° C. and 75% relative humidity for a period of one month.