Patent ID: 7452865

Claim:
A peptide selected from the group having the formulae: R 1 -A 0 -A 1 -A 2 -Asp-Ala-A 5 -A 6 -Thr-A 8 -A 9 -A 10 -A 11 -A 12 -Val-Leu-A 15 -A 16 -Leu-Ser-A 19 -A 20 -A 21 -A 22 -Leu-Gln-Asp-Ile-A 27 -A 28 -A 29 -A 30 -R 2 wherein R 1 is a member of the group consisting of a) PhAc, Hca, Dat, IndAc Ipa, 1-Nac, 2-Nac, 1-Npr, 2-Npr, Ibu; CH 3 (CH 2 ) n CO, or HOOC(CH 2 ) n CO, where n is an integer from 2 to 20, and b) any other straight chain, branch chain, saturated, unsaturated or poly unsaturted aliphatic carboxyl group of 2-30 carbon atoms and any carbocyclic or heterocyclic aromatic carboxyl group of 3-8 carbon atoms containing at least one atom of the group S, N, and O in the hetercyclic ring, A 0 is Phe, D-Phe, Arg, D-Arg, or is absent A 1 is Tyr or His, A 2 is D-Arg or D-Cit, A 5 is Ile or Val, A 6 is Phe, Tyr, Nal, or Phe(Y), in which Y=F, Cl, Br, or I, A 8 is Asn, D-Asn, Cit, D-Cit, Gln, D-Gln, Ser, D-Ser, Thr, D-Thr, Ala, D-Ala, Abu, D-Abu or Aib, A 9 is His, D-His, Amp, D-Amp, Gup, or D-Gup, A 10 is Tyr, Tyr(Et), Tyr(Me); Phe(Y), in which Y=H, F, Cl, Br, or I; Amp, His, Cha, Chg, Bpa, Dip, Trp, Trp(For), Tpi, 1-Nal, 2-Nal, 3-Pal, 4-Pal, Phe(NH 2 ), or Phe(NO 2 ), A 11 is His, D-His, Arg, D-Arg, Cit Har, D-Har, Amp, D-Amp, Gup, or D-Gup, A 12 is Lys, D-Lys, Orn, D-Orn, Har, D-Har, Cit, D-Cit, Nle, or Ala, A 15 is Gly, Ala, Abu, Aib, Nle, Gln, Cit or His, A 16 is Gln or Arg, A 19 is Ala or Abu, A 20 is His, D-His, Arg, D-Arg, or Cit, A 21 is Lys, D-Lys, Orn, D-Orn, Cit, or D-Cit, A 22 is Leu, Ala or Aib, A 27 is Met, Leu, Nle, Abu, or D-Arg, A 28 is Arg, D-Arg, Har, D-Har, Ser, Asn, Asp, Ala, Abu, or Cit, A 29 is Arg, D-Arg, Har, D-Har, Cit D-Cit, or Agm, A 30 is Arg, D-Arg, Har, D-Har, Cit, D-Cit Agm, absent, R 2 is —NH 2 , —NH—NH 2 , —NH—OH, —NHR 3 , —NR 3 R 4 , —OH, or —OR 3 , in which R 3 and R 4 are any of C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkinyl, C 7-16 phenylalkyl, —C 6 H 5 , or —CH(C 6 H 5 ) 2 ; provided that if A 29 is Agm then A 30 and R 2 are absent, and if A 30 is Agm then R 2 is absent, and pharmaceutically acceptable salts thereof.