Patent ID: RE38761

Claim:
A method for inhibiting, in a patient, cell proliferation associated with a disorder selected from the group consisting of psoriasis, atherosclerosis and restenosis comprising administering to said patient an effective amount of a composition comprising, in admixture with a pharmaceutically acceptable carrier, a compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of (A) a substituted styrene compound having the formula wherein: one of R 1 and R 2 is alkyl, —H, —CN, —OH, —CONRR or —CSNRR; the other of R 1 and R 2 is alkyl, —H, —CN, —OH, —CONRR, —CSNRR, —CONHR 9 , —CONHCH 2 CN, —CH═C(CN) 2 , —C(NH 2 )═C(CN) 2 or —NHCHO wherein R 1 and R 2 are not both alkyl, —H, —CN or —OH; R is alkyl or —H; R 3 is alkyl, —H, —CN, —OH, —CONRR, —CSNRR, —CH 2 CN or —CH═C(CN)COHN 2 ; R 4 , R 5 , R 6 , R 7 and R 8 are each independently alkyl, —H, —CN, halo, —NO 2 or —NHCOCH 3 ; R 3 and R 7 together may be —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —or, starting from R 3 , —CONH—; R 9 is, —CONH 2 , R 10 is alkyl, halo or —NO 2 ; R 11 is alkyl, —CN, halo, —NO 2 or —NHCOCH 3 ; R 12 is alkyl, —H, halo,; n is 0 to about 6; and m is 2 to about 10, provided that when one of R 1 and R 2 is —CH═C(CN) 2 , at least one of R 3 , R 4 , R 5 , R 6 , R 7 and R 8 is not —H; (B) an α-substituted benzylidene malononitrile compound having the formula wherein: R 3 is alkyl, —CN, —OH, —CONRR, —CSNRR, —CH 2 CN or —CH═C(CN)CONH 2 ; R is alkyl or —H; and R 4 , R 5 , R 6 , R 7 and R 8 are each independently alkyl, —H, —CN, halo, —NO 2 or —NHCOCH 3 ; (C) an α-unsubstituted benzylidene malononitrile compound having the formula wherein: at least one of R 4 , R 5 , R 6 , R 7 and R 8 is C 2 to about C 6 alkyl or —CN; the remainder of R 4 , R 5 , R 6 , R 7 and R 8 are each independently alkyl, —H, —CN, halo, —NO 2 or —NHCOCH 3 ; and R is alkyl or —H; and (D) a bicyclic benzylidene malononitrile compound having the formula wherein: R 3 and R 7 together are —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —or, starting from R 3 , —CONH—; and R 4 , R 5 R 6 and R 8 are each independently alkyl, —H, —CN, halo, —NO 2 or —NHCOCH 3 .