Patent ID: 8242138

Claim:
A compound of formula I: where: R 1 is selected from C 3-9 cycloalkyl and aryl; R 2 is aryl; R 3 is —C 0-1 alkylene-OH; or —CR 1 R 2 R 3 together form a group of formula: where A is —O—; and where R 4 is Q is a bond, X′ is —N—, X and X″ are each —CH 2 —, Y is —CH— and Z is —NR 6 —; each R 5 is independently fluoro or —C 1-4 alkyl; and a is 0 or an integer from 1 to 3; R 6 and R 7 are independently H or —C 1-4 alkyl; b is an integer from 1 to 4; Ar is aryl or heteroaryl, optionally substituted with 1-5 R 8 groups independently selected from halo, —C 1-4 alkyl, —C 0-4 alkylene-OH, cyano, —C 0-2 alkylene-COOH, —C(O)O—C 1-4 alkyl, —O—C 1-4 alkyl, —S—C 1-4 alkyl, —CONR 8a R 8b , NH—C(O)—C 1-4 alkyl, —N-di-C 1-4 alkyl, and —N + (O)O, where R 8a and R 8b are independently H or —C 1-4 alkyl; where R 1 and R 2 are optionally substituted with 1 to 5 R a groups independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —C 3-6 cycloalkyl, cyano, halo, —OR b , —C(O)OR b , —SR b , —S(O)R b , —S(O) 2 R b , —C(O)NR c R d and —NR c R d ; where each R b is independently selected from H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; and each R c and R d is independently selected from H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; where alkyl, alkenyl, alkynyl, alkylene, and cycloalkyl group in R a-d and R 4-8 is optionally substituted with 1 to 5 fluoro atoms; where each cycloalkyl in R a-d is optionally substituted with 1 to 3 substituents independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, cyano, halo, —O(C 1-4 alkyl), —S(C 1-4 alkyl), —S(O)(C 1-4 alkyl), —S(O) 2 (C 1-4 alkyl), —NH 2 , —NH(C 1-4 alkyl) and —N(C 1-4 alkyl) 2 , where each alkyl, alkenyl and alkynyl group is optionally substituted with 1 to 5 fluoro substituents; and the —(CH 2 ) b — group is optionally substituted with 1 or 2 substituents independently selected from —C 1-2 alkyl and —OH; or a pharmaceutically acceptable salt thereof.