Patent ID: 8637706

Claim:
A nuclear receptor binding agent (NRBA) compound or its isomer, pharmaceutically acceptable salt, ester, or any combination thereof, represented by the structure of formula VI: wherein X is CO; R 1 and R 3 , are independently halogen, —CHO, —CHNOH, CH═CHCO 2 H, hydroxyalkyl group of 1 to 7 carbon atoms, hydroxyl, alkoxy group of 1 to 7 carbon atoms, cyano, CF 3 , NH 2 , NHR, NHCOR, sulfonamide, SO 2 R, aryl or protected hydroxyl; R 2 is —CHO, —CHNOH, CH═CHCO 2 H, hydroxyalkyl, hydroxyl, alkoxy, cyano, CF 3 , NH 2 , NHR, NHCOR, sulfonamide, SO 2 R, aryl, or protected hydroxyl; R 8 , R 9 , and R 10 are independently hydrogen, halogen, CHO, CHNOH, CH═CHCO 2 H, hydroxyalkyl group of 1 to 7 carbon atoms, hydroxyl, alkoxy group of 1 to 7 carbon atoms, cyano, CF 3 , NH 2 , NHR, NHCOR, sulfonamide, SO 2 R, aryl, or protected hydroxyl; R is alkyl group of 1 to 7 carbon atoms, hydrogen, haloalkyl group of 1 to 7 carbon atoms, dihaloalkyl group of 1 to 7 carbon atoms, trihaloalkyl group of 1 to 7 carbon atoms, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl group of 1 to 7 carbon atoms, CN, NO 2 , or OH; and j, k, l are independently 1-4.