Patent ID: 6867203

Claim:
A compound of formula I or a pharmaceutically-acceptable salt or prodrug thereof, wherein R 1 is haloalkyl; R 2 is haloalkyl; R 3 is trans-cinnamide wherein trans-cinnamide is defined as wherein R 8 and R 9 are hydrogen and R 10 and R 11 together with N are heterocyclyl; R 4 is hydrogen; R 5 is hydrogen; and Ar is aryl, wherein the aryl is substituted with a substituted heterocyclyl, wherein the heterocyclyl is chosen from 4-, 5-, 6- and 7-membered rings containing 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur; the 4- and 5-membered rings have zero to two double bonds and the 6- and 7-membered rings have zero to three double bonds, the heterocyclyl being optionally substituted with alkyl, halogen, hydroxy or alkoxy substituents, wherein the heterocyclyl optionally comprises a group chosen from: (I) bicyclic, tricyclic and tetracyclic groups in which any of the above heterocyclic rings is fused to one or two rings independently selected from an aryl ring, a cyclohexane ring, a cyclohexene ring, a cyclopentane ring, a cyclopentene ring, and another monocyclic heterocyclic ring; (ii) bridged bicyclic groups where a monocyclic heterocyclic group is optionally bridged by an alkylene group selected from (iii) compounds of the formula where X* and Z* are independently selected from —CH 2 —, —CH 2 NH—, —CH 2 O—, —NH— and —O—, with the proviso that at least one of X* and Z* is not —CH 2 —, and Y* is selected from —C(O)— and —(C(R″) 2 ) v —, where R″ is hydrogen or alkyl of one to four carbons, and v is 1-3; and wherein aryl is defined as a mono- or bicyclic carbocyclic, aromatic ring.