Patent ID: 8519159

Claim:
A 3,6-substituted pyran group-containing compound having the structural formula: wherein A, A′, and B are individually selected from the group of optionally substituted C 4 -C 14 aryl and heteroaryl wherein heteroatoms of heteroaryl A and/or A′ are selected from the group consisting of O, N, and S; Z is selected from the group consisting of a chemical bond and —Y—(CH 2 ) o — wherein Y is NH or O and o is 0, 1, 2, 3, or 4; R is H or C 1-8 alkyl; W is selected from the group consisting of hydrogen and —OH wherein when W is hydrogen, B is phenyl or a phenyl substituted with C 1-4 alkyl, C 2-6 alkenyl, C 2-6 optionally halogenated alkynyl, C 2-6 hydroxyalkynyl, COOR′, —OH, or —NH 2 ; R′ is C 1-18 alkyl, C 5-10 cycloalkyl, or C 2-18 alkenyl; R 2 is C 1-8 alkyl, C 5-6 cycloalkyl, or C 2-8 alkenyl; and n and m individually are 0, 1, 2, 3, or 4, and wherein any carbon of —(CH 2 ) n may be substituted by OR 4 wherein R 4 is C 1-8 alkyl, C 2-18 alkylene, or —COOR 5 wherein R 5 is C 1-18 alkyl or C 2-18 alkylene, or a pharmaceutically acceptable salt, ester, ether or carbamate thereof.