Patent ID: 8822447

Claim:
A compound of formula (I) wherein a is an integer from 0 to 1; X is selected from the group consisting of —O— and —S—; R 1 is selected from the group consisting of C 1-4 alkyl and halogenated C 1-4 alkyl; b is an integer from 0 to 2; R 2 is selected from the group consisting of halogen, hydroxy, cyano, nitro, NR A R B , C 1-4 alkyl, —O—C 1-4 alkyl, —S—C 1-4 alkyl and halogenated C 1-4 alkyl; wherein R A and R B are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; R 3 is selected from the group containing of hydrogen, halogen, hydroxy, —O—C 1-4 alkyl and NR C R D ; wherein R C and R D are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; Y is CH and Z is CH; Q is selected from the group consisting of -(L 1 ) c -(Ring A), -(L 1 ) c -(Ring B)-(Ring C) and -(Ring B)-L 1 -(Ring C); c is an integer from 0 to 1; L 1 is selected from the group consisting of —CH 2 —, —CH(OH)—, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, —CH═CH—, —CH═CH—CH 2 —, —O—, —O—CH 2 —, —C(O)—, —C(O)—C(O)—, —C(O)—CH 2 —, —C(O)—N(R 4 )—, —N(R 4 )—, —N(R 4 )—CH 2 —, —N(R 4 )—CH 2 CH 2 —, —N(R 4 )—(CO)—, —N(R 4 )—C(O)—CH 2 —, —N(R 4 )—C(O)—CH 2 —CH 2 — and —N(R 4 )—C(O)—N(R 5 )—; wherein R 4 and R 5 are each independently selected from the group consisting of hydrogen and C 1-2 alkyl; (Ring A) is selected from the group consisting of phenyl and 4 to 10 membered, nitrogen containing ring structure; wherein (Ring A) is optionally substituted with a substituent selected from the group consisting of halogen, C 1-4 alkyl, cyano, NR E R F , —C(═NH)—NR E R F , —C(O)—CH 2 —NR E R F , —C(O)—CH 2 CH 2 —NR E R F and phenyl; wherein R E and R F are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; (Ring B) is selected from the group consisting of phenyl and 4 to 10 membered, nitrogen containing ring structure; (Ring C) is selected from the group consisting of 4 to 10 membered, nitrogen containing ring structure; wherein (Ring C) is optionally substituted with one to two substituents independently selected from the group consisting C 1-4 alkyl; or a pharmaceutically acceptable salt thereof.