Patent ID: 7687652

Claim:
An oxazaphospholane compound of formula (1): wherein R 1 represents a C 1 -C 24 aliphatic moiety which may be a saturated or unsaturated, branched or linear chain, optionally comprising an aliphatic ring, R 2 represents a hydrogen atom or hydrophobic group, the hydrophobic group is a C 1 -C 24 aliphatic moiety which is a saturated or unsaturated, branched or linear aliphatic chain, the aliphatic chain optionally comprising an aliphatic ring, the aliphatic chain or ring optionally substituted with one or more substituents comprising a heteroatom selected from the group consisting of oxygen, halogen, nitrogen and sulfur, Z represents a protecting group selected from the group consisting of methoxymethyl (MOM), tetrahydropyranyl (THP), diphenylmethyl, triethylsilyl (TES), t-butyldimethylsilyl (TBDMS), mesitoate, 9-fluorenylmethyl carbonate (f-moc) , t-butyl carbamate (t-boc), and Si(R 5 ) 3 , R 5 may be the same or different in the same moiety and represent a C 1 -C 6 branched or straight alkyl group or an aryl group, and X represents a chemical moiety that is replaced under nucleophilic attack in the presence of a nucleophilic reagent and is selected from the group consisting of a halogen atom, borate, ethylene chlorophosphite, methyl phosphodichloridite, chloro-N,N-diisopropylaminomethyxophosphite, and [(isopropyl)2N]2POCH2CH2CN, wherein X is optionally substituted with a group selected from the group consisting of an alcohol, an ether, a polyether and a sugar moiety, wherein the alcohol contains an aliphatic moiety selected from the group consisting of an aliphatic chain, an amino aliphatic chain, a heteroatom comprising an aliphatic chain, an aliphatic chain comprising a cyclic ring which ring may be saturated or partially saturated and an aryl group, the aliphatic chain may be a branched or straight, saturated or unsaturated chain.