Patent ID: 7423047

Claim:
A compound of formula (1): wherein: the dashed line joining A and C(R a ) is present and represents a bond and A is a —C(R b )═; R a is a hydrogen atom or a C 1-4 alkyl group; R b is a hydrogen atom; R is a hydrogen atom or a straight or branched C 1-6 alkyl group; X is an —S— atom; Y is a —CH═ or —C(R 10 )═ group wherein R 10 is —CN, —CONH 2 , —CONHet 1 , —CON(R 12 )Het, —CON(R 12 )Alk 5 Het or —CO 2 Alk 6 ; —NHet 1 represents pyrrolidinyl, piperazinyl, morpholinyl or piperidinyl; Het represents cyclopentyl, cyclohexyl, pyrrolidinyl, piperazinyl, morpholinyl or piperidinyl; R 12 represents hydrogen or C 1-6 alkyl; Alk 5 is a straight or branched C 1-6 alkylene chain; Alk 6 is a straight or branched C 1-8 alkyl group; n is zero or the integer 1; Alk 1 is —CH 2 — or —CH 2 CH 2 —; L 1 is a covalent bond; Cy 1 is an optionally substituted C 3-7 cycloalkyl, phenyl, thienyl, pyridyl or indolyl group, wherein the optional substituents on Cy 1 are selected from halogen, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, cyano, —CO 2 CH 3 , —CO 2 C(CH 3 ) 3 , nitro, amino, —NHCH 3 , —N(CH 3 ) 2 , —C(O)CH 3 and —NHCOCH 3 ; Ar is an optionally substituted phenyl, wherein the optional substituents on Ar are selected from halogen, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, cyano, —CO 2 CH 3 , —CO 2 C(CH 3 ) 3 , nitro, amino, —NHCH 3 , —N(CH 3 ) 2 , —C(O)CH 3 and —NHCOCH 3 ; or a pharmaceutically acceptable salt thereof.