Patent ID: 8853280

Claim:
A method for topical treatment of onychomycosis in a subject in need thereof, wherein the method comprises applying to a nail of the subject a composition comprising: (a) about 1% weight/weight positively charged terbinafine, (b) about 1% to about 20% weight/weight phospholipid, (c) at least one solubilizer selected from the group consisting of water, ethanol, polyols, glycols, surfactants, phospholipids, polysorbate 20, polysorbate 80, and complexing agents, (d) at least one enhancer selected from the group consisting of ethanol, alkanols, fatty alcohols, fatty acids, fatty acid esters, polyols, polysorbate 20, polysorbate 80, propylene glycol, 1,3-butanediol, terpenes, amides, cyclic amides, pyrrolidone derivatives, essential oils, phospholipids and surfactants, (e) at least one antioxidant, (f) at least one preservative, (g) at least one humectant selected from the group consisting of 1,3-butanediol, propylene glycol, glycerin, sorbitol, lactic acid, methyl gluceth-10, aloe vera extract, sodium PCA, and polyethylene glycol, and (h) at least one viscosity increasing agent, wherein the composition has a pH in the range of about 3.5 to about 7.0.