Patent ID: 7960115

Claim:
A method for screening compounds capable of modulating an interaction between a DNA binding protein comprising an amino acid sequence as set forth in SEQ ID NO: 2 and DNA comprising a c-myc replication origin, said method comprising the steps of: a) contacting in a medium a peptide comprising an amino acid sequence as set forth in SEQ ID NO:2 and a polynucleotide comprising a sequence of a c-myc replication origin; wherein the peptide is detectably bindable to at least a portion of the c-myc replication origin polynucleotide sequence; b) adding to said medium a compound to be screened for its capacity to modulate the binding of the peptide to the polynucleotide; c) determining binding of said compound to said peptide; and d) detecting change in binding of said peptide to said polynucleotide; wherein detection of binding of said compound to said peptide and change in binding of said peptide to said polynucleotide is indicative that said compound is capable of modulating an interaction between a DNA binding protein comprising an amino acid sequence as set forth in SEQ ID NO: 2 and DNA comprising a c-myc replication origin.