Patent ID: 8568689

Claim:
A uPAR imaging agent of formula Ia, Z 1 —W 1 —X 0 —X 1 -Phe-X 2 —X 3 —X 4 -Leu-Trp-X 5 —X 6 —W 2 —Z 2 (Ia) wherein, X 0 represents 1-5 amino acids, X 1 , X 2 , X 3 , X 4 and X 5 independently represent one amino acid, Phe represents phenylalanine, Leu represents leucine, Trp represents tryptophan, X 6 represents 0 to 5 amino acids or is identified by formula (Ib), β-Ala-Lys(Z 1 —W 1 —X 0 —X 1 -Phe-X 2 —X 3 —X 4 -Leu-Trp-Xs) (Ib) wherein the denotations are defined as for formula Ia, and wherein β-Ala represents β-Alanine, Lys represents lysine, β-Ala of formula Ib is linked to X 5 of formula Ia, and wherein W 1 and W 2 are independently absent, a monodisperse polyethylene glycol (PEG) building block comprising 1 to 10 units of said building block, or 1 to 10 amino acid residues or combinations thereof; Z 1 and Z 2 are independently absent or a Z group; Z is an imageable moiety capable of detection either directly or indirectly in in vivo diagnostic imaging; with the proviso that at least one of W 1 and W 2 is present and at least one of Z 1 and Z 2 is present.