Patent ID: 8252896

Claim:
A process for the preparation of Bivalirudin comprising the steps of: a) condensing the segment AspPheGlu(tBu)Glu(tBu)IleProOBn (SEQ ID NO: 5) (S3) and the segment FmocGlyGlyGlyGlyAsnGlyOH (SEQ ID NO: 2) (S2) in a first organic solvent; b) deprotecting the product of step a); c) condensing the product of step b) and the segment Boc-D-PheProArg(HCl)ProOH (S1) in a second organic solvent; d) deprotecting the benzyl group of the product of step c); e) condensing the product of step d) and the segment Glu(tBu)Glu(tBu)Tyr(tBu)LeuOtBu (SEQ ID NO: 6) (S4) in a third organic solvent; and f) deprotecting the product of step e) to obtain Bivalirudin.