Patent ID: 7943619

Claim:
A compound of formula I wherein X is O or NH; R 1 is phenyl, pyridinyl, or pyrimidinyl each optionally substituted with one, two or three halo, R 2 is C 1-4 alkyl, H or C 1-4 haloalkyl; R 3 , R 4 , and R 5 each are independently H, C 1-7 alkyl, optionally substituted with one or more halo, cyano, or hydroxy, C 1-7 alkoxy, optionally substituted with one or more halo, CN, halo, NO 2 , —C(O)—R a , wherein R a is hydroxy, C 1-7 alkoxy, C 1-7 alkyl, phenoxy or phenyl, —NR b R c , wherein R b and R c are each independently hydrogen, C 1-7 alkyl, —C(O)C 1-7 alkyl, optionally substituted with one or more halo, —C(O)(CH 2 ) m —O—C 1-7 alkyl, wherein m is 0, 1, 2, 3, 4, 5 or 6, —C(O)C(O)OC 1-7 -alkyl, —C(O)CH 2 C(O)OC 1-7 -alkyl, —C(O)R i , wherein R i is phenyl or 5- to 6-membered heteroaryl, each optionally substituted with one or more E, —C(O)—C 3-7 cycloalkyl, optionally substituted with one or more B, —C(O)—R ii , wherein R ii is 3- to 7-membered heterocyclyl, optionally substituted by one or more A, 3- to 7-membered heterocyclyl, optionally substituted with one or more A, 5- or 6-membered heteroaryl, optionally substituted with one or more E, —C(O)—NR d R e , wherein R d and R e are each independently H, C 1-7 alkyl, optionally substituted with one or more halo, hydroxy, or cyano, —(CH 2 ) t —C 3-7 cycloalkyl, optionally substituted by one or more B, and t is 0, 1, 2, 3 or 4, —(CH 2 ) u —O—C 1-7 alkyl, wherein u is 2, 3, 4, 5 or 6, —(CH 2 ) x -heterocyclyl, wherein x is 0, 1, 2, 3 or 4, and wherein heterocyclyl is optionally substituted by one or more A R d and R e together with the nitrogen to which they are bound form a heterocyclyl moiety, optionally substituted with one or more A, or R 3 together with the neighboring pyridazine-nitrogen form a 5-membered annelated aromatic ring with two additional ring nitrogen atoms, the annelated ring is optionally substituted by R f , wherein R f is C 1-7 -alkyl, —C(O)OC 1-7 alkyl, —C(O)C 1-7 alkyl, 5- or 6-membered heteroaryl or phenyl, each optionally substituted by one or more E, A is hydroxy, oxo, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 haloalkyl, C 1-7 hydroxyalkyl, halo, or CN, B is halo, hydroxy, CN, C 1-4 alkyl, or C 1-4 haloalkyl, E is halo, CN, NO 2 , hydroxy, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 haloalkyl, C 1-7 hydroxyalkyl, C 1-7 cyanoalkyl, C 1-7 haloalkoxy, or C 3-7 cycloalkyl, or a pharmaceutically acceptable salt thereof.