Patent ID: 7528237

Claim:
An isolated antibody or fragment thereof that specifically binds to mature human TNF-α, wherein when the antibody or fragment thereof binds mature human TNF-α, the induction of endothelial procoagulant activity is inhibited, tumor receptor binding is unaffected; and wherein the antibody or fragment thereof competitively inhibits sheep anti-sera raised against a TNF-α peptide for specific binding to mature human TNF-α, wherein the TNF-α peptide is a peptide consisting of residues Val 1 -Arg 2 -Ser 3 -Ser 4 -Ser 5 -Arg 6 -Thr 7 -Pro 8 -Ser 9 -Asp 10 -Lys 11 -Pro 12 -Val 13 -Ala 14 -His 15 -Val 16 -Val 17 -Ala 18 (peptide 301) of mature human TNF.