Patent ID: 8828922

Claim:
A method for suppression, prevention, delaying the onset or treatment of diabetes by inhibition of insulitus, comprising orally administering to an individual in need thereof a therapeutically effective amount of an active agent consisting of a fragment of Hsp60 or analog thereof in aqueous solution, in conjunction with a low antigenicity diet wherein a diabetogenic protein is replaced with a hydrolyzed or denatured form of the protein, wherein the fragment of Hsp60 or analog thereof consists of residues 437-460 of hsp60 having the sequence Val-Leu-Gly-Gly-Gly-Cys-Ala-Leu-Leu-Arg-Cys-Ile-Pro-Ala-Leu-Asp-Ser-Leu-Thr-Pro-Ala-Asn-Glu-Asp (SEQ ID NO:1) or DiaPep277 having the sequence: Val-Leu-Gly-Gly-Gly-Val-Ala-Leu-Leu-Arg-Val-Ile-Pro-Ala-Leu-Asp-Ser-Leu-Thr-Pro-Ala-Asn-Glu-Asp (SEQ ID NO:2), or a salt or functional derivative thereof, and wherein the Hsp60 fragment or analog is administered in a dosage ranging from about 0.1 mg/kg to about 10 mg/kg.