Patent ID: 8202852

Claim:
A compound of Formula (I): a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of any of the foregoing, wherein: n is selected from 1 and 2; Y and Z are independently selected from Formula (1), Formula (2), and Formula (3): wherein: each X is independently selected from O and S; each R 1 and R 2 is independently selected from hydrogen, C 1-8 alkyl, substituted C 1-8 alkyl, C 1-8 heteroalkyl, substituted C 1-8 heteroalkyl, C 3-12 cycloalkyl, substituted C 3-12 cycloalkyl, C 4-20 cycloalkylalkyl, substituted C 4-20 cycloalkylalkyl, C 4-20 heterocycloalkylalkyl, substituted C 4-20 heterocycloalkylalkyl, C 5-12 aryl, substituted C 5-12 aryl, C 5-12 heteroaryl, substituted C 5-12 heteroaryl, C 6-20 arylalkyl, substituted C 6-20 arylalkyl, C 6-20 heteroarylalkyl, and substituted C 6-20 heteroarylalkyl; each R 4 is independently selected from C 1-8 alkyl, substituted C 1-8 alkyl, C 1-8 heteroalkyl, substituted C 1-8 heteroalkyl, C 3-12 cycloalkyl, substituted C 3-12 cycloalkyl, C 4-20 cycloalkylalkyl, substituted C 4-20 cycloalkylalkyl, C 4-20 heterocycloalkylalkyl, substituted C 4-20 heterocycloalkylalkyl, C 5-12 aryl, substituted C 5-12 aryl, C 5-12 heteroaryl, substituted C 5-12 heteroaryl, C 6-20 arylalkyl, substituted C 6-20 arylalkyl, C 6-20 heteroarylalkyl, and substituted C 6-20 heteroarylalkyl; and each R 6 is independently selected from hydrogen, C 1-8 alkyl, substituted C 1-8 alkyl, C 5-12 cycloalkyl, substituted C 5-12 cycloalkyl, C 5-12 aryl, and C 5-12 substituted aryl; R 3 is selected from hydrogen, C 1-8 alkyl, substituted C 1-8 alkyl, C 1-8 heteroalkyl, substituted C 1-8 heteroalkyl, C 5-12 cycloalkyl, substituted C 5-12 cycloalkyl, C 6-20 cycloalkylalkyl, substituted C 6-20 cycloalkylalkyl, C 6-20 heterocycloalkylalkyl, substituted C 6-20 heterocycloalkylalkyl, C 5-12 aryl, substituted C 5-12 aryl, C 5-12 heteroaryl, substituted C 5-12 heteroaryl, C 6-20 arylalkyl, substituted C 6-20 arylalkyl, C 6-20 heteroarylalkyl, and substituted C 6-20 heteroarylalkyl; and each R 7 and R 8 is independently selected from hydrogen, C 1-8 alkyl, and substituted C 1-8 alkyl.