Patent ID: 8633174

Claim:
A pharmaceutical composition comprising a first compound of Formula I or a physiologically acceptable salt thereof, and a cyto-protective amount of a manganese chelate of N,N′-dipyridoxyl ethylenediamine-N,N′-diacetic acid (MnPLED): wherein X is CH or N, each R 1 independently is hydrogen or —CH 2 COR 5 ; R 5 is hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R 2 independently is a group ZYR 6 ; Z is a bond, CO, or a C 1-3 alkylene or oxoalkylene group optionally substituted by a group R 7 ; Y is a bond, an oxygen atom or a group NR 6 ; R 6 is a hydrogen atom, COOR 8 , an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR 8 , CONR 8 2 , NR 8 2 , OR 8 , ═NR 8 , ═O, OP(O)(OR 8 )R 7 and OSO 3 M; R 7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R 8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation; R 3 is a C 1-8 alkylene group, a 1,2-cykloalkylene group, or a 1,2-arylene group, optionally substituted with R 7 ; and each R 4 independently is hydrogen or C 1-3 alkyl.