Patent ID: 8364228

Claim:
A device for transdermal sampling comprising: a flexible substrate; at least one pair of sample electrodes disposed on the flexible substrate; an anchor layer covering at least a portion of at least one pair of sample electrodes; a first pair of electrically conductive paths coupled to the at least one pair of sample electrodes; a second pair of electrically conductive paths; and at least one resistive element coupled to the second pair of electrically conductive paths, wherein: the at least one resistive element is disposed proximate to the at least one pair of sample electrodes and configured to provide a sequence of thermal heating to generate a temperature sufficient to disrupt stratum corneum cells of a subject without damaging the stratum corneum cells to thereby allow interstitial fluid to pass through capillary openings formed through the stratum corneum cells and into contact with the at least one pair of sample electrodes.