Patent ID: 8647820

Claim:
A method for reducing reperfusion injury in a mammal suffering from said reperfusion injury, the method comprising administering into regional blood vessels in a region of the mammal affected by said reperfusion injury a therapeutically effective amount of a circular dumbbell oligodeoxynucleotide (CDODN) comprising two loop structures and a stem structure, and reducing said reperfusion injury, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of NF-κB transcriptional factor, wherein the CDODN comprises two identical stem loop structures covalently linked by enzymatic ligation, wherein each of the identical stem loop structures comprises SEQ ID NO: 15, and wherein the therapeutically effective amount of the CDODN is administered in a Hemagglutinating Virus of Japan (HVJ) liposome composition.