Patent ID: 8263635

Claim:
A compound of Formula (Ib) wherein R 50 , R 51 and R 52 are each independently H, halo, -OH, -CN, (C 1 -C 4 )alkyl, halo-substituted(C 1 -C 4 )alkyl, hydroxy-substituted (C 1 -C 4 )alkyl, -(CH 2 ) r -O(C 1 -C 4 )alkyl, -(CH 2 ) r —CH(O(C 1 -C 4 )alkyl) 2 , -NH 2 , -NH(C 1 -C 4 )alkyl, -N((C 1 -C 4 )alkyl) 2 , -NHC(O)-(C 1 -C 4 )alkyl, —C(O)NH 2 , -C(O)-NH(C 1 -C 4 )alkyl, -C(O)-N((C 1 -C 4 )alkyl) 2 , or -C(O)-O(C 1 -C 4 )alkyl; wherein n is 1; R 53 is (i) phenyl optionally substituted with 1 to 3 substituents selected from halo, -CN, -OH, (C 1 -C 6 )alkyl, halo-substituted (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, -NH 2 , -NH(C 1 -C 4 )alkyl, -N((C 1 -C 4 )alkyl) 2 , -NHC(O)-(C 1 -C 4 )alkyl, -C(O)NH 2 , -C(O)-NH(C 1 -C 4 )alkyl, -C(O)-N((C 1 -C 4 )alkyl) 2 , or a 5- to 6-membered heterocycle, (ii) biphenyl optionally substituted with 1 to 3 substituents selected from (C 1 -C 4 )alkyl or halo, (iii) phenyl fused to an additional phenyl, a 5- to 6-membered heteroaryl, a 5- to 6-membered partially or fully saturated cycloalkyl, or a 5- to 6-membered partially or fully saturated heterocycle, where said fused phenyl is optionally substituted with 1 to 4 substituents each independently selected from halo, -CN, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy-substituted (C 1 -C 4 )alkyl, halo-substituted (C 1 -C 4 )alkyl, cyclopropyl, oxo, -NH 2 , -NH(C 1 -C 4 )alkyl, -N((C 1 -C 4 )alkyl) 2 , -NHC(O)-(C 1 -C 4 )alkyl, or ═N-OH, (iv) 5- to 6-membered heteroaryl optionally substituted with 1 to 3 substituents selected from halo, -CN, -OH, (C 1 -C 6 )alkyl, halo-substituted (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, -NH 2 , -NH(C 1 -C 4 )alkyl, -N((C 1 -C 4 )alkyl) 2 , -NHC(O)-(C 1 -C 4 )alkyl, -C(O)NH 2 , -C(O)-NH(C 1 -C 4 )alkyl, -C(O)-N((C 1 -C 4 )alkyl) 2 , or a 5- to 6-membered heterocycle, (v) 5- to 6-membered heteroaryl fused to another 5- to 6-membered heteroaryl, phenyl, 5- to 6-membered partially or fully saturated cycloalkyl, or a 5- to 6-membered partially or fully saturated heterocycle, where said fused heteroaryl is optionally substituted with 1 to 4 substituents each independently selected from halo, -CN, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy-substituted (C 1 -C 4 )alkyl, halo-substituted (C 1 -C 4 )alkyl, cyclopropyl, oxo, -NH 2 , -NH(C 1 -C 4 )alkyl, -N((C 1 -C 4 )alkyl) 2 , -NHC(O)-(C 1 -C 4 )alkyl, or ═N-OH; R 54 is (C 1 -C 4 )alkyl, halo-substituted (C 1 -C 4 )alkyl, or -CH 2 OH, or two R 54 taken together with the carbon atom(s) to which they are attached form a 3- to 6-membered fully or partially saturated carbocyclic; p is 0, 1, 2, or 3; with the proviso that when R 50 , R 51 , and R 52 are H and R 53 is phenyl, R 53 is not unsubstituted or substituted with halogen or CF 3 , or a pharmaceutically acceptable salt thereof.