Patent ID: 7402684

Claim:
A compound of formula: wherein Ar is selected from the group consisting of phenyl; and phenyl substituted with from one to three substituents independently selected from the group consisting of halogen, loweralkyl, loweracyl, loweralkoxy, fluoroloweralkyl, fluoroloweralkoxy, hydroxy, hydroxy(C 1 -C 4 )alkyl, formyl, formyl(C 1 -C 4 )alkyl, cyano, cyano(C 1 -C 4 )alkyl, benzyl, benzyloxy, phenyl, substituted phenyl, heteroaryl, heterocyclylalkyl, substituted heteroaryl, and nitro; X is selected from the group consisting of direct bond, O, SO, S(O 2 ), NR 1 , CH 2 , CF 2 , CH 2 CH 2 , CH 2 NR 1 , NR 1 CH 2 , CH═CH, C═O, CH 2 C═O, CR 1a R 1b , OCR 1a R 1b , CR 1a R 1b O; SO 2 NR 1 , NR 1 SO 2 , C(═O)NR 1 and NR 1 C(═O); R 1 is selected separately in each occurrence from the group consisting of H and lower alkyl; R 1a is selected from the group consisting of H, OH and lower alkyl; R 1b is selected from the group consisting of H and lower alkyl, or R 1a and R 1b taken together may form a 3-6 membered ring, which may optionally contain a heteroatom chosen from O, S, and N; HetAr is a phenyl ring attached via a ring carbon to Q, further characterized in that Q and X cannot be on adjacent positions in said aryl ring; Q is —O—; n is an integer selected from 1-5; HET is selected from the group consisting of pyrrolidine and pyrrolidine substituted with one or two substituents independently selected from the group consisting of halogen, hydroxyl, amino, carboxy, loweralkyl, loweracyl, loweralkoxy, N-oxide, fluoroloweralkyl, fluoroloweralkoxy, formyl, cyano, benzyl, benzyloxy, phenyl, heteroaryl and nitro; and taken together ZW is H or Z is (CH 2 ) 1-10 , in which one or two (CH 2 ) may optionally be replaced by —O—, —NR 1 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)—, provided that said —O—, —NR 1 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)— are not at the point of attachment to HET and are separated by at least one —(CH 2 )—; W is selected from the group consisting of acyl, hydroxyl, carboxyl, amino, —C(O)NHR 4 , aminoacyl, —COOalkyl, —CHO, heterocyclyl, substituted aryl, substituted heterocyclyl, sulfonamide, —C(O)fluoroalkyl, —C(O)CH 2 C(O)Oalkyl, —C(O)CH 2 C(O)Ofluoroalkyl, —SH, —C(O)NH(OH), —C(O)N(OH)R 4 , —N(OH)C(O)OH, —N(OH)C(O)R 4 ; and R 4 is selected from the group consisting of H, (C 1 -C 4 ) alkyl, and phenyl(C 1 -C 4 ) alkyl; with the provisos that; (a) when HET is (S)-pyrrolidine or rac-pyrrolidine Ar is phenyl or halo-substituted phenyl, and HetAr is p-phenylene, then the Z—W combination is other than H.