Patent ID: 7335680

Claim:
A compound of the following Formula III: wherein each R′ is independently hydrogen; optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted heteroalkyl; optionally substituted heteroalkenyl; optionally substituted heteroalkynyl; optionally substituted carbocyclic aryl; optionally substituted aralkyl; optionally substituted heteroalicyclic, optionally substituted heteroaryl; optionally substituted heteroarylalkyl; or optionally substituted heteroalicyclicalkyl; G is halogen; optionally substituted alkyl, or optionally substituted alkylcarboxylate ester; p is an integer of from zero to 4; Y is (CR 2 R 3 ) q which may include 0 or 1 C═C double bonds, q is from 1 to 6 and R 2 and R 3 are each independently selected at each occurrence from the group consisting of hydrogen, optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; hydroxy, halogen; and optionally substituted alkoxy; and U and U′ are each independently selected from hydrogen, hydroxy or optionally substituted alkyl; A is (CR 2 R 3 ) q′ where q′ is an integer from 1 to 6; B is (CR 2 R 3 ) n , or absent; or A and B taken in combination form an optionally substituted 1,2-vinylene group or an ethynyl group; V is (CR 2 R 3 ) m , optionally substituted divalent aryl, or optionally substituted divalent heteroaryl; L is C(O)Z; Z is hydroxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, amino, NR 4 R 5 , optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, or optionally substituted heteroarylalkyl; n is an integer selected from 0-3; m is an integer selected from 1-6; R 4 and R 5 are independently selected at each occurrence from the group consisting of hydrogen optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, and optionally substituted heteroarylalkyl, or R 4 and R 5 taken in combination is an optionally substituted heterocycloalkyl; and pharmaceutically acceptable salts thereof.