Patent ID: 8273743

Claim:
A compound of formula I: wherein A is a carbocycle; X is NR 4 C(O), NR 4 C(S), NR 4 C(NH), NR 4 SO, NR 4 SO 2 , NR 4 C(O)NH, NR 4 C(S)NH, C(O)NR 4 , C(S)NR 4 , C(NH)NR 4 , or NR 4 PO(OH) wherein R 4 is H or alkyl; Y is N, CH or CR 3 ; R 1 is selected from the group consisting of alkyl, cycloalkyl, aryl or a heterocycle each of which is optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl, haloalkyl or alkoxy; and said cycloalkyl, aryl and heterocycle are optionally further substituted with —(CH 2 ) s -(Q) u -(CH 2 ) t —Z wherein Q is C(O), S(O), SO 2 , C(O)O, OC(O), NR 4 C(O), NR 4 C(S), NR 4 SO, NR 4 SO 2 , NR 4 C(O)NH, NR 4 C(S)NH, C(O)NR 4 , or C(S)NR 4 ; and Z is hydroxy, amino, halogen, alkylsulfonyl, alkoxy, alkoxycarbonyl, haloalkyl, a carbocycle, a heterocycle or a carbocycle or heterocycle substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl, haloalkyl, hydroxyalkyl, alkoxy or alkoxyalkoxy; and s and t are independently 0, 1, 2, 3, 4 or 5 and u is 0 or 1; R 2 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R 3 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; m is 0, 1, 2, or 3; n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.