Patent ID: 8076376

Claim:
A compound having the formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: R 1 , R 2 , and R 3 , together with the carbon atom to which they are attached, are an (S)-trifluoromethyl carbinol group of the formula: or an (R)-trifluoromethyl carbinol group of the formula: R 4 is a member selected from the group consisting of hydrogen, halogen, (C 1 -C 8 )alkyl and (C 3 -C 8 )cycloalkyl; R 5 is selected from the group consisting of hydrogen, —OH, halogen, (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )heteroalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )heterocycloalkyl, C(O)R′, C(O)NR′ 2 , NR′ 2 , NR′C(O)R′, CN, NO 2 , aryl, and heteroaryl; R 6 is aryl or heteroaryl, or R 6 optionally may be combined with R 5 to form a 5- to 6-membered fused ring containing L, the nitrogen atom to which L is attached, and the sulfur atom to which R 6 is attached; L is selected from the group consisting of a direct bond, (C 1 -C 4 )alkylene and (C 2 -C 4 )alkenylene; wherein any cycloalkyl portion, heterocycloalkyl portion, aryl or heteroaryl portion is optionally substituted with from one to four members selected from the group consisting of halogen, —CN, —NO 2 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR″, —OR′, —SR′, —OC(O)R′, —C(O)N(R′) 2 , —S(O)R″, —SO 2 R″, —SO 2 N(R′) 2 , —N(R′) 2 and —NR′C(O)R′; wherein each occurrence of R′ is independently H or an unsubstituted member selected from the group consisting of (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 4 ) alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )heterocycloalkyl, heteroaryl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, (C 3 -C 8 ) heterocycloalkyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkyl, wherein two R′ groups, when attached to the same nitrogen atom, can be combined with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl group; and wherein each occurrence of R″ is independently an unsubstituted member selected from the group consisting of (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )heterocycloalkyl, heteroaryl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl and aryl(C 1 -C 6 )alkyl.