Patent ID: 6974588

Claim:
A transdermal patch for administering a volatile liquid drug transdermally to a patient comprising a) a top backing layer that is impermeable to the drug; b) an intermediate, cast, amine-compatible solid silicone adhesive layer which underlies the backing layer, has a thickness of from about 25 microns to about 100 microns, and contains from about 5 to about 50 wt. % of the drug based on the total dry weight of the drug and adhesive, and is a source in the patch of the drug; c) a solid acrylic adhesive layer having a thickness of from about 25 microns to about 100 microns and comprising a copolymer of (i) vinyl acetate, (ii) acrylic acid, and (iii) at least one monomer selected from the group consisting of acrylate and methacrylate, and which underlies and is in diffusional contact with the silicone adhesive layer; and d) a removable release liner layer underlying the acrylic adhesive layer, wherein the relative thickness of layers “b” and “c”, and the concentration of drug initially present in layer “b” is selected to provide a drug flux profile which is characterized by an initial period during which the flux rises to a level suitable for administering a therapeutic amount of the drug, and a second period during which the drug flux is sustained above said level, said second period lasting for at least twice as long as said initial period, and wherein the amount of drug in the patch is sufficient to provide a therapeutically effective amount of drug to the patient over a period of at least about several hours and wherein the drug is a combination of nicotine and mecamylamine and the patch is capable of administering 0.2 to 1.5 mg nicotine per hour and 0.02 to 1 mg mecamylamine per hour to the patient.