Patent ID: 8404713

Claim:
A compound of formula (I): the N-oxide form, the pharmaceutically acceptable addition salt, the quaternary ammonium salt and the stereochemically isomeric form thereof, wherein n is 0, 1 or 2; R 1 is C 1-3 alkyl; R 2 and R 3 are each independently selected from hydrogen, halogen, C 1-6 alkyl, cyano, hydroxy, C 1-6 alkyloxy, C 3-6 cycloalkyloxy, cyanoC 1-4 alkyl, hydroxyC 1-4 alkyloxy, C 1-4 alkyloxyC 1-4 alkyloxy, aminoC 1-4 alkyloxy, C 1-4 alkylaminoC 1-4 alkyloxy, di(C 1-4 alkyl)aminoC 1-4 alkyloxy, aminocarbonyl or C 2-4 alkynyl; R 4 and R 5 are each independently selected from hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, hydroxy, C 1-6 alkyloxy, C 1-6 alkyloxymethyl or hydroxyC 1-6 alkyl, or R 4 and R 5 together form ═O; Z is a group of formula —NR 6 R 7 wherein R 6 is hydrogen or C 1-4 alkyl; R 7 is C 1-4 alkyloxyC 1-4 alkyl or a group of formula —(CH 2 ) t -L 1 (a-1) wherein t is 0, 1, 2 or 3 and L 1 is phenyl or phenyl substituted with one or two substituents independently selected from hydrogen, halo, cyano, C 1-4 alkyl, C 1-4 alkyloxy, hydroxycarbonyl, C 1-4 alkyloxycarbonyl or aminocarbonyl; or L 1 is a heterocyclic ring system selected from: wherein R 8a is selected from hydrogen, C 1-4 alkyl, hydroxyC 1-4 alkyl or aminocarbonyl; q is 0, 1 or 2; and each R 8b is independently selected from hydrogen, halogen, cyano, C 1-4 alkyl, hydroxyC 1-4 alkyl, C 1-4 alkyloxy or aminocarbonyl; and R 9 is hydrogen, C 1-4 alkyl, phenyl or a heterocyclic ring system selected from: wherein R 10 is selected from hydrogen, halogen, cyano, C 1-4 alkyl or C 1-4 alkyloxy; or Z is a heterocyclic ring system selected from: wherein R 11 is hydrogen, C 1-4 alkyl, hydroxyl, cyano, hydroxyC 1-4 alkyl or aminocarbonyl; and R 12a is hydrogen or C 1-4 alkyloxyC 1-4 alkyl; or —X-L 2 (e-1) R 12b is hydrogen, C 1-4 alkyloxyC 1-4 alkyl or C 1-6 alkyloxyC 1-6 alkylamino; or —X-L 2 (e-1) X is —(CH 2 ) p — in which p is 0, 1, 2 or 3; L 2 is C 3-6 cycloalkyl, phenyl or phenyl substituted with one or two substituents independently selected from halo, C 1-4 alkyl, C 1-4 alkyloxy, amino, cyano or trifluoromethyl; or L 2 is a heterocyclic ring system selected from: wherein R 13 is selected from hydrogen, halo, C 1-4 alkyl, C 1-4 alkyloxy, C 2-4 alkynyl, aminocarbonyl, cyano, trifluoromethyl, amino, hydroxyC 1-4 alkylaminocarbonyl, hydroxycarbonyl or C 1-4 alkyloxycarbonyl.