Patent ID: 8212071

Claim:
A process for the preparation of (S)-Pregabalin comprising: one or more of steps i)-iv): i) conversion of compound 24 to compound 25: whereby said conversion of compound 24 occurs by process comprising reacting compound 24 with an amidation reagent, ii) conversion of compound 25 to compound 26: whereby said conversion of compound 25 occurs by process comprising a Hoffman reaction, iii) conversion of compound 26 to compound 27: whereby said conversion of compound 26 occurs by process comprising reacting compound 26 with ammonia and an alkali metal, iv) conversion of compound 27 to compound (S)-pregabalin: whereby said conversion of compound 27 occurs by process comprising reacting compound 27 with an acid, wherein Ar is a C 6-10 aromatic group, R is a straight or branched C 1-4 alkyl, ester, or carboxylic acid group and R′ is methyl.