Patent ID: 7855050

Claim:
A method of diagnosing whether a subject has an increased risk of bleeding, comprising a step of detecting that is selected from: (A) detecting presence or absence of at least two single nucleotide polymorphisms (SNPs) in a nucleic acid of a sample obtained from a Caucasian subject to determine whether the subject is homozygous for a GPVI b allele, wherein presence of the GPVI b allele is indicated by a GPVI allele with a C nucleotide at position 655 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 199 of mature GPVI amino acid sequence, or dbSNP ID rs1613662, and a T nucleotide at position 950 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 297 of mature GPVI amino acid sequence, wherein homozygosity for the GPVI b allele indicates that the Caucasian has an increased risk of bleeding compared to a Caucasian lacking the GPVI b allele, and (B) detecting presence or absence of at least five single nucleotide polymorphisms (SNPs) in a nucleic acid of a sample obtained from a non-Caucasian subject to determine whether the subject is homozygous for a GPVI b allele, wherein presence of the GPVI b allele is indicated by a GPVI allele with a C nucleotide at position 655 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 199 of mature GPVI amino acid sequence, or dbSNP ID rs1613662, a G nucleotide at position 709 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 217 of mature GPVI amino acid sequence, or dbSNP ID rs1654416, a G nucleotide at position 745 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 229 of mature GPVI amino acid sequence, or dbSNP ID rs2304167, a T nucleotide at position 950 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 297 of mature GPVI amino acid sequence, and an A nucleotide at position 964 of SEQ ID NO:1, or at a corresponding position encoding amino acid position 302 of mature GPVI amino acid sequence, wherein homozygosity for the GPVI b allele indicates that the non-Caucasian has an increased risk of bleeding compared to a non-Caucasian lacking the GPVI b allele; and diagnosing that the subject has an increased risk of bleeding if the subject is homozygous for the GPVI b allele.