Patent ID: 7670626

Claim:
A solid oral pharmaceutical composition which consists essentially of: (A) about 0.0005 to about 70 wt. % of a pharmaceutically effective amount of solid particles of a water-soluble bioactive material which is a bisphosphonate and which has a low bioavailability in the gastrointestinal tract of an animal and which is a solid at room temperature and which has a predetermined melting point; (B) about 5 to about 80 wt. % of a glyceride enhancer which is normally a solid at room temperature and which has a melting point lower than the melting point of the bioactive material and which is present in an amount that increases the bioavailability of the bioactive material when it is present within the gastrointestinal tract of an animal; (C) about 10 to about 50 wt. % of a polyoxyethylene/polyoxypropylene block copolymer surfactant; and optionally (D) about 0.01 to about 20 wt. % of another surfactant which has an HLB of about 9 to about 20 and/or about 0.1 to about 50 wt. % of a biocompatible oil; wherein the enhancer is present in the composition in the form of a continuous solid phase in which the solid particles of bioactive material are dispersed uniformly and encapsulated in the composition, wherein the composition is stable, and wherein the solid particles have a mean particle size of about 1 nm to about 1 mm.