Patent ID: 7566727

Claim:
A compound in accord with formula II: wherein: E represents or CH 2 , NH, O or S; R 1 is selected from hydrogen, halogen or a substituted or unsubstituted 5- or 6-membered aromatic or heteroaromatic ring having 0, 1 or 2 nitrogen atoms, 0 or 1 oxygen atoms, and 0 or 1 sulfur atoms, or selected from a substituted or unsubstituted 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system having 0, 1, 2 or 3 nitrogen atoms, 0 or 1 oxygen atoms, and 0 or 1 sulfur atoms, said aromatic or heteroaromatic rings or ring systems, when substituted, having substituents selected from —C 1 -C 6 alkyl, —C 3 -C 6 cycloalkyl, —C 1 -C 6 alkoxy, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, halogen, —CN, —NO 2 , —CF3, —S(O) m R 2 wherein m is 0, 1 or 2, —NR 2 R 3 , —NR 2 (CO)R 3 , —CH 2 NR 2 R 3 , OR 2 , —CH 2 OR 2 , —C(O)NR 2 R 3 , or —CO 2 R 4 ; R 2 and R 3 are independently selected at each occurrence from hydrogen, —C 1 -C 4 alkyl, —C 1 - C 4 alkoxy, —C 3 -C 6 cycloalkyl, aryl, heteroaryl, —C(O)R 4 , —CO 2 R 4 or —SO 2 R 4 , or R 2 and R 3 in combination is —(CH 2 ) j G(CH 2 ) k —or -G(CH 2 ) j G- wherein G is oxygen, sulfur, NR 4 , or a bond, j is 0, 1, 2, 3 or 4 and k is 0, 1, 2, 3 or 4, and R 4 is independently selected at each occurrence from hydrogen, —C 1 -C 4 alkyl, aryl, or heteroaryl; or a stereoisomer, enantiomer, in vivo-hydrolysable precursor or pharmaceutically-acceptable salt thereof.