Patent ID: 8461152

Claim:
A method for the treatment of a disorder selected from the group consisting of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior comprising administering a therapeutically effective amount of a compound of formula I wherein R 1 is aryl or heteroaryl, each of which is unsubstituted or substituted with one or more substituents independently selected from A, R 2 is H, C 1-12 -alkyl, unsubstituted or substituted with one or more OH, halo, cyano or C 1-12 -alkoxy, —(CH 2 ) q —R a , wherein R a is phenyl or 5- or 6-membered heteroaryl, each of which is unsubstituted or substituted with one or more substituents independently selected from A, —(CH 2 ) r NR i R ii , —C(O)—C 1-12 -alkyl, wherein C 1-12 -alkyl is unsubstituted or substituted with one or more OH, halo, cyano or C 1-12 -alkoxy, —C(O)(CH 2 ) q OC(O)—C 1-12 -alkyl, —C(O)(CH 2 ) q NR i R ii , —C(O)O—C 1-12 -alkyl, wherein alkyl is unsubstituted or substituted with one or more OH, halo, cyano or C 1-12 -alkoxy, —S(O) 2 —C 1-12 -alkyl, or —S(O) 2 NR i R ii , R i and R ii are each independently H, C 1-12 -alkyl, or together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl containing one or two heteroatoms selected from N, O and S, which heterocycloalkyl is unsubstituted or substituted by one or more substituents independently selected from B, q is 1, 2, 3 or 4, r is 2, 3 or 4, A is halo, cyano, OH, C 1-7 -alkyl, halo-C 1-7 alkyl, C 1-7 -alkoxy, halo-C 1-7 -alkoxy, or hydroxy-C 1-7 -alkyl, B is oxo, halo, OH, C 1-7 -alkyl or C 1-7 -alkoxy, and R 3 is Cl or F, or a pharmaceutically acceptable salt thereof.