Patent ID: 8513246

Claim:
A method of inhibiting the glycine transporters selected from the group consisting of glyt1 and glyt2 in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or a stereoisomer thereof: wherein R represents a hydrogen atom; n represents 1; X represents a group of formula CH; R 1 represents either a phenyl or naphthyl group optionally substituted with one or more substituents chosen from halogen atoms, linear or branched (C 1 -C 6 )alkyl, hydroxyl and (C 1 -C 6 )alkoxy groups, the trifluoromethyl group, or a cyclohexyl group, or a heteroaryl group chosen from thienyl, pyridinyl, oxazolyl, furanyl, thiazolyl, quinolinyl, and isoquinolinyl groups; R 2 represents either a hydrogen atom, or one or more substituents chosen from halogen atoms, trifluoromethyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, thienyl, phenyloxy, hydroxyl, mercapto, thio(C 1 -C 6 )alkyl and cyano group or a group of formula —NR 4 R 5 , SO 2 NR 4 R 5 , —SO 2 —(C 1 -C 6 )alkyl, —SO 2 -phenyl, —CONR 4 R 5 , —COOR 7 , —CO—(C 1 -C 6 )alkyl, —CO-phenyl, —NHCOR 8 , —NHSO 2 —(C 1 -C 6 ) alkyl, —NHSO 2 -phenyl and —NHSO 2 NR 4 R 5 or a group of formula —OCF 2 O—attached at the 2- and 3-positions of the phenyl group; the groups (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, —SO 2 —(C 1 -C 6 )alkyl, —CO—(C 1 -C 6 )alkyl and —NHSO 2 —(C 1 -C 6 )alkyl being optionally substituted with one or more groups R 3 ; the groups phenyl, —SO 2 -phenyl, —CO-phenyl and —NHSO 2 -phenyl being optionally substituted with a group R 6 ; R 3 represents a halogen atom, or a phenyl, (C 1 -C 6 )alkoxy or —NR 4 R 5 group; R 4 and R 5 represent, independently of each other, a hydrogen atom or a (C 1 -C 6 )alkyl group or R 4 and R 5 form with the nitrogen atom bearing them a pyrrolidine ring, a piperidine ring or a morpholine ring; R 6 represents a hydrogen atom, a halogen atom, a trifluoromethyl group, a cyano group, a hydroxyl group, a mercapto group, a (C 1 -C 6 )alkyl or (C 1 -C 6 )alkoxy group; R 7 represents a hydrogen atom or a (C 1 -C 6 )alkyl group optionally substituted with one or more groups R 3 , or a phenyl group optionally substituted with a group R 6 ; and R 8 represents a (C 1 -C 6 )alkyl group optionally substituted with one or more groups R 3 , or a (C 1 -C 6 )alkoxy group, or a phenyl group optionally substituted with a group R 6 .