Patent ID: 8153780

Claim:
A reporter unit for detecting a target molecule, said reporter unit comprising either: a. a coenzyme A (CoA) ester selected from the group consisting of (R)-3-Hydroxyacyl-CoA, (R)-3-Hydroxypropyryl-CoA, (R)-3-Hydroxybutyryl-CoA and Lactoyl-CoA, or (R)-3-Hydroxybutyryl-N-acetylcysteamin, where R is H, CH3, C2H5, C3H7, C4H9, C5H11, C6H13, C7H15, C8H17, C9H19, C10H21, C11H23, C12H25, C13H27 or C14H29 attached to a target molecule specific probe, or b. a target molecule specific probe attached to a first enzyme said first enzyme is capable of cleaving a pre-substrate comprising a coenzyme A (CoA) ester selected from the group consisting of (R)-3-Hydroxyacyl-CoA, (R)-3-Hydroxypropyryl-CoA, (R)-3-Hydroxybutyryl-CoA and Lactoyl-CoA, or (R)-3-Hydroxybutyryl-N-acetylcysteamin, where R is H, CH3, C2H5, C3H7, C4H9, C5H11, C6H13, C7H15, C8H17, C9H19, C10H21, C11H23, C12H25, C13H27 or C14H29, or c. a target molecule specific probe attached to a second enzyme, capable of employing a coenzyme A (CoA) ester selected from the group consisting of (R)-3-Hydroxyacyl-CoA, (R)-3-Hydroxypropyryl-CoA, (R)-3-Hydroxybutyryl-CoA and Lactoyl-CoA, or (R)-3-Hydroxybutyryl-N-acetylcysteamin, where R is H, CH3, C2H5, C3H7, C4H9, C5H11, C6H13, C7H15, C8H17, C9H19, C10H21, C11H23, C12H25, C13H27 or C14H29 as a substrate in a polymerization reaction to obtain a detectable structure.