Patent ID: 6900317

Claim:
A process for preparing an acid addition salt of 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine, which has the formula the process comprising the following steps: (a) dissolving 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine (the base) in water or an aqueous buffer system with a pH between 4 and 8, (b) combining the solution of step (a) thus prepared with an excess of an acid, and (c) removing the solvent by spray-drying.