Patent ID: 8460708

Claim:
A kit for use in medical applications, comprising: (a) a dry powder composition comprising i. a first component having a first hydrophilic polymer core substituted with m thiol groups, where m≧2; and ii. a second component having a second hydrophilic polymer core substituted with n electrophilic groups, where n≧2 and m+n>4, and wherein the electrophilic group is independently —(CO)—O—(CO)—R (where R is an alkyl group), CH═CH—CH═O, —CH═CH—C(CH 3 )═O, —N═C═O, —N═C═S, —SO 2 CH═CH 2 , —O(CO)—C═CH 2 , —O(CO)—C(CH 3 )═CH 2 , —S—S—(C 5 H 4 N), —O(CO)—C(CH 2 CH 3 )═CH 2 , —CH═CH—C═NH, —COOH, —(CO)O—N(COCH 2 ) 2 , —O—(CO)—O—N(COCH 2 ) 2 , —CHO, —(CO)O—N(COCH 2 ) 2 —S(O) 2 OH, and —N(COCH) 2 ; (b) a first solution having a pH within the range of about 2.1-2.3, and being configured to be mixed with (a) to provide a homogeneous solution of (a) and (b); and (c) a second solution having a pH within the range of about 6.0 to 11.0 and being configured to be mixed with the homogeneous solution of (a) and (b), wherein the thiol group and the electrophilic groups are non-reactive in a dry environment, and wherein each of (a), (b) and (c) is packaged separately and admixed immediately prior to use.