Patent ID: 8338423

Claim:
A method of treating an individual with hyperphenylalaninemia (HPA), said method comprising: administering to the individual a pharmacological chaperon having a stabilizing activity on phenylalanine hydroxylase (PAH) enzyme and its physiologically compatible addition salts and solvates, comprising, as an active ingredient, a compound of formula IV wherein: X 3 and X 5 are independently selected from the group of O and S; X 4 is O, S or NR B ′ wherein R B is selected from the group of H and C 1 to C 6 alkyl; R 12 and R 13 are independently selected from H, C 1 to C 6 alkyl, aryl, substituted aryl, heterocyclic, or substituted heterocyclic; and R 14 and R 15 are independently selected from H, C 1 to C 6 alkyl, C 3 to C 6 alkenyl, aryl, substituted aryl, heterocyclic, or substituted heterocyclic.