Patent ID: 7186745

Claim:
A method of treatment, in a warm-blooded animal, to inhibit and/or reverse and/or alleviate symptom of angiogenesis and/or any disease state associated with angiogenesis comprising administering to said warm-blooded animal a therapeutically effective amount of a compound of Formula (I), wherein: X is selected from: —O—, —S—, —S(O)—, —S(O 2 )—,—N(R 5 )—, —C(O)—, —C(O)N(R 5 )— or —N(R 5 )C(O); R 1 is independently selected from: amino, halo, hydroxy, —OPO 3 H 2 , C 1-4 alkyl, or C 1-4 alkoxy, wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R 2 is selected from: hydrogen or C 1-4 alkyl; R 3 is selected from: hydrogen, halo, hydroxy, hydroxyC 1-14 alkyl, cyano, cyanoC 1-4 alkyl, carboxy, carboxyC 1-4 alkyl, C 1-4 alkanoyl, C 1-4 alkanoylC 1-4 alkyl, carbamoyl, carbamoylC 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxycarbonyl, C 1-4 alkoxycarbonylC 1-4 alkyl, C 1-4 alkoxycarbonylamino, amino, N—C 1-4 alkylamino, NN-diC 1-4 alkylamino, aminoC 1-4 alkyl, N—C 1-4 alkylaminoC 1-4 alkyl, NN-diC 1-4 alkylaminoC 1-4 alkyl, ureido, or C 1-4 alkylureyleno; R 4 is independently selected from: C 1-4 alkyl, C 1-4 alkoxy or halo; R 5 is selected from: hydrogen or C 1-4 alkyl; n is 0 or 1; p is 0, 1, 2, or 3; and q is 0, 1 or 2; or a salt, pro-drug or solvate thereof.