Patent ID: 7423012

Claim:
A compound of general Formula I or a pharmaceutically acceptable salt wherein: R 1 is selected from the group consisting of: C 1 -C 6 alkyl, substituted with one or more basic groups selected from amino, amidino and guanidino; Six-membered aromatic heterocyclyl, containing a single heteroatom, which heteroatom is nitrogen, and substituted with one or more basic groups selected from amino, amidino and guanidino; and Six-membered aliphatic heterocyclyl, containing a single heteratom, which heteroatom is nitrogen; R 2 is selected from the group consisting of H, methyl, halogen, and hydroxy; R3 is selected from the group consisting of COOR 5 , SO(OR 5 ), SO 3 R 5 , B(OR 5 ) 2 , P═O(R 5 )(OR 5 ), tetrazole, and a carboxylic acid isostere; R 4 represents a R 5 is H, C 1 -C 6 alkyl, or aryl; R 6 is C 1 -C 6 alkyl, aryl, cycloalkyl, heterocyclyl, or an optionally N-substituted H 2 N—CH(Z)—CONH—CH(Z)- or H 2 N—CH(Z)- group; X is C(Z) 2 ; Y is C(Z) 2 or a single bond; and Z is independently selected from the group consisting of H, C 1 -C 6 alkyl, aryl, cycloalkyl, and heterocyclyl.