Patent ID: 8202720

Claim:
A myocardial toxicity test chip, comprising: a transparent substrate; a cardiomyocyte population holding area arranged on the transparent substrate and having a first plurality of cell holders (CH G ) holding stably pulsating cardiomyocytes; a cell communication channel formed by a second plurality of cell holders (CH n ) arranged in tandem in which the CH n holds cardiomyocytes or fibroblasts, wherein the cardiomyocyte population holding area adjoins the cell communication channel at a first cell holder (CH 1 ) of the CH n ; a liquid culture medium area defined by a surface of the transparent substrate and a wall formed around the perimeter of the cardiomyocyte population holding area and the cell communication channel; a microelectrode placed in one cell holder (CH G ) in the cardiomyocyte population holding area on the transparent substrate; a further microelectrode placed in each of the second plurality of cell holders (CH n ) of the cell communication channel on the transparent substrate; a reference electrode placed in the liquid culture medium area; and a leading line connected to the microelectrode in the cardiomyocyte population holding area, a leading line connected to the plurality of the further microelectrodes, and a leading line connected to the reference electrode.