Patent ID: 8546608

Claim:
A compound having Formula (I): or a pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein: R 1 is C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 3 -C 7 cycloalkyl; R 2 is H; Q is —B(OH) 2 , —B(OR 14 ) 2 , or a cyclic boronic ester wherein said cyclic boronic ester contains from 2 to 20 carbon atoms, and, optionally, a heteroatom which can be N, S, or O; R 14 is H, C 1 -C 4 alkyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl; X is R A C(═O)—; R A NHC(═O)—, R A S(O) 2 —, R A SC(═O)—, or R A ; R A is C 1 -C 20 alkyl optionally substituted with R 20 ; C 2 -C 20 alkenyl optionally substituted with R 20 ; C 2 -C 20 alkynyl optionally substituted with R 20 ; carbocyclyl optionally substituted with 1-5 R 22 ; or heterocarbocyclyl optionally substituted with 1-5 R 22 ; R 20 is selected from the group consisting of: —OR 20a , —SR 20a , —S(═O)R 20a , —S(═O) 2 R 20a , —S(═O) 2 —NHR 20a , —SC(═O)R 20a , —C(═O)R 20a , —C(═O)NHR 20a , —C(═O)O—R 20a , phthalimido, —(O-alkyl) r , —O-alkyl-OH, —(O-alkyl) r —OH, —OR 20c , —SR 20c , —O-alkyl-R 20c , —S- alkyl-R 20c , —S(═O)—R 20c , —S(═O) 2 —R 20c , —S(═O) 2 —NHR 20c , —SC(═O)R 20c , —C(═O)R 20c , —C(═O)OR 20c , —C(═O)NHR 20c , carbocyclyl optionally substituted with 1-5 R 22 ; and heterocarbocyclyl optionally substituted with 1-5 R 22 ; R 20a is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, or C 2 -C 20 alkynyl; wherein said alkyl, alkenyl, or alkynyl is optionally substituted by one or more halo, C 1 -C 4 alkyl, aryl, heteroaryl or —NHR 20b ; R 20c is carbocyclyl optionally substituted with 1-5 R 22 ; or heterocarbocyclyl optionally substituted with 1-5 R 22 ; R 22 is selected from the group consisting of: C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, phenyl, halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino, carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—, alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—, (alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS, alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —; and r is 2, 3, 4, 5, 6, 7, 8, 9, or 10.