Patent ID: 7160677

Claim:
A screening method for identifying putative chemotherapeutic agents which comprises: providing a DRTF1 transcription factor, said transcription factor being a heterodimeric complex of a first component and a second component, the first component being selected from the group consisting of (i) the protein of SEQ ID NO: 2; or (ii) a polypeptide comprising amino acids identical to amino acids 160–220 of SEQ ID NO: 2; and the second component being E2F-1 or an E2F-1 family member having at least 70% homology to E2F-1 over the DNA binding region; providing a putative chemotherapeutic agent; and determining the extent to which said agent is capable of disrupting or inhibiting the formation or activity of said heterodimeric complex whereby the agent is identified as a putative chemotherapeutic agent if it shows ability to disrupt or inhibit the formation or activity of said complex.