Patent ID: 7427625

Claim:
A compound of Formula (I) wherein R 1 is selected from the group consisting of —N(Ra,Rb), —O(Ra) and —N(Ra)—(CH 2 ) p —Ar 1 ; Ra is selected from the group consisting of hydrogen and C 1-8 alkyl; Rb is selected from the group consisting of hydrogen, C 1-8 alkyl and hydroxy-(C 1-8 )alkyl; alternatively, when R 1 is —N(Ra,Rb), then Ra and Rb may be taken together with the nitrogen of attachment to form a heterocyclyl ring having at least one said nitrogen atom, wherein said ring is optionally substituted with one, two or three substituents each selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, halogen, hydroxy, hydroxy-(C 1-8 )alkyl, hydroxy-(C 1-8 )alkoxy, amino and C 1-8 alkyl-amino; p is 0, 1, 2, 3 or 4; Ar 1 is selected from the group consisting of aryl, heteroaryl, benzofused heteroaryl, heterocyclyl and benzofused heterocyclyl each optionally substituted with one, two or three substituents each selected from the group consisting of R 4 —(C 1-8 )alkyl, R 4 —(C 2-8 )alkenyl, R 4 —(C 2-8 )alkynyl, R 4 —(C 1-8 )alkoxy, cyano, halogen, nitro, halo-(C 1-8 )alkyl, halo-(C 1-8 )alkoxy, hydroxy, hydroxy-(C 1-8 )alkyl, hydroxy-(C 1-8 )alkoxy, C 1-8 alkoxy-carbonyl, C 1-8 alkoxy-carbonyl-amino, amino-(C 1-8 )alkyl, C 1-8 alkyl-amino-(C 1-8 )alkyl, amino, C 1-8 alkyl-amino, C 3-8 cycloalkyl-amino, heterocyclyl-amino (optionally substituted on heterocyclyl with one or two C 1-8 alkyl substituents) and heterocyclyl-(C 1-8 )alkyl-amino (optionally substituted on heterocyclyl with one or two C 1-8 alkyl substituents); R 4 is hydrogen or is one, two or three substituents each selected from the group consisting of C 3-8 cycloalkyl, aryl, heteroaryl and heterocyclyl each optionally substituted with one, two or three substituents each selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkoxy-(C 1-8 )alkyl, cyano, halogen, hydroxy, halo-(C 1-8 )alkyl, halo-(C 1-8 )alkoxy, hydroxy-(C 1-8 )alkyl, hydroxy-(C 1-8 )alkoxy, C 1-8 alkoxy-carbonyl, amino-(C 1-8 )alkyl, C 1-8 alkyl-amino-(C 1-8 )alkyl, amino, C 1-8 alkyl-amino, C 1-8 alkoxy-carbonyl-amino; R 2 is selected from the group consisting of aryl, heteroaryl, benzofused heteroaryl, heterocyclyl and benzofused heterocyclyl each optionally substituted with one, two or three substituents each selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, cyano, halogen, halo-(C 1-8 )alkyl, halo-(C 1-8 )alkoxy, hydroxy, heteroaryl-oxy, aryl-oxy (optionally substituted on heteroaryl and aryl with one, two or three substituents each selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy and halogen); and R 3 is hydrogen or is selected from the group consisting of R 4 —(C 1-8 )alkyl, R 4 —(C 2-8 )alkenyl, R 4 —(C 2-8 )alkynyl, halogen, hydroxy, C 3- cycloalkyl, heteroaryl, aryl and heterocyclyl, optionally substituted on heteroaryl and aryl with one, two or three substituents each selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy and halogen.