Patent ID: 7393869

Claim:
A pharmaceutical composition comprises a pharmaceutically acceptable carrier, diluent or excipient and a compound of formula (Ia): wherein: each p is independently 1 to 5; A is linker of four atoms and is selected from the group consisting of an optionally substituted straight or branched alkylene chain of four carbons, an optionally substituted straight or branched alkenylene chain of four carbons, —R 8a —C(R 2a )—N(R 5a )—, —R 8a —N(R 5a )—C(R 2a )—, —R 8a —O—C(R 2a )—, —R 7a —O—C(R 2a )—R 7a —, —R 8a —O—R 7a —, —R 7a —C(R 2a )—N(R 5a )—S(O) t — (where t is 0 to 2), —R 8a —N(R 5a )—R 7a , —R 8a —S(O) t —R 7a — (where t is 0 to 2), —R 9a —N(R 5a )—, —R 9a —O—, and —R 9a —C(R 2a )—; R 1a and R 2a are each independently ═O or ═S; R 3a is alkyl, alkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, chloro, iodo, bromo, haloalkyl, haloalkoxy, nitro, cyano, —N═N—O—R 11a , —OR 10a , —C(O)OR 10a , —C(O)N(R 10a ) 2 , —N(R 12a ) 2 , —N(R 10a )C(O)R 10a , —N(R 10a )C(O)OR 11a , —S(O) t R 10a (where t is 0 to 2), —S(O) t N(R 10a ) 2 (where t is 0 to 2), or heterocyclylalkyl; R 4a is hydrogen, alkyl, aralkyl, aryl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl; R 5a is hydrogen, alkyl, aralkyl, or aryl; R 6a is alkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxy, nitro, cyano, —N═N—O—R 11a , —C(O)N(R 10a ) 2 , —N(R 10a ) 2 , —N(R 10a )C(O)R 10a , —N(R 10a )C(O)OR 11a , —S(O) t R 10a (where t is 0 to 2), —S(O) t N(R 10a ) 2 (where t is 0 to 2), —S(O) t NH—R 14a , heterocyclyl or heterocyclylalkyl; each R 7a is an optionally substituted alkylene chain of one carbon; each R 8a is an optionally substituted straight or branched alkylene or alkenylene chain of two carbons; each R 9a is an optionally substituted alkylene chain of three carbons; each R 10a is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aralkyl or aryl; R 11a is hydrogen, alkyl or aralkyl; R 12a is hydrogen, aryl or aralkyl; and R 14a is a thiazole; as a single stereoisomer, a mixture of stereoisomers, or as a racemic mixture of stereoisomers; or as a solvate or polymorph; or as a pharmaceutically acceptable salt thereof.