Patent ID: 7846960

Claim:
A compound of formula p is 0 or 1 or 2; X 1 is C or N and X 2 is C or N; provided that both X 1 and X 2 are not N; R 1 and R 2 are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, halo, —SC 1 -C 6 alkyl, and —S—C 1 -C 3 haloalkyl; each R 3 is independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, and halo; R 4a is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, C 4 -C 8 alkylcycloalkyl, C 1 -C 6 alkoxy, and C 1 -C 6 haloalkoxy; R 4b is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, C 4 -C 8 alkylcycloalkyl, C 1 -C 6 alkoxy, and C 1 -C 6 haloalkoxy; R 5 and R 5a are independently selected from the group consisting of hydrogen, and C 1 -C 3 alkyl; R 6 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, NO 2 , C 3 -C 8 cycloalkyl, and C 4 -C 8 alkylcycloalkyl; L 1 is selected from the group consisting of a bond, C 1 -C 6 alkyl, CR a ═CR b , ethynyl, C 1 -C 5 alkylene, C 1 -C 5 alkyl-S—, C 1 -C 5 alkyl-O—, N(R c )—C 1 -C 5 alkyl, and —C 1 -C 5 alkyl-N(R c )—, wherein R a and R b are independently selected from the group consisting of hydrogen and C 1 -C 3 alkyl; and R c is independently selected from the group consisting of H, C 1 -C 5 alkyl, C 1 -C 3 alkylphenyl and C 4 -C 8 alkylcycloalkyl; Ar 1 is selected from the group consisting of indolyl, thienyl, benzothienyl, naphthyl, phenyl, pyridinyl, pyrazolyl, oxazolyl, benzoisoxazolyl, benzofuranyl, pyrrolyl, thiazolyl, benzoisothiazolyl, indazolyl, and furanyl, each optionally substituted with one or two groups independently selected from the group consisting of hydroxy, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, —OC 1 -C 2 alkylphenyl, N(R C )SO 2 C 1 -C 6 alkyl, —C(O)R 10 , and NHC(O)R 10 ; R 7 is selected from the group consisting of COOH, C 1 -C 5 alkylCOOH, —O—C 1 -C 5 alkylCOOH, C 2 -C 4 alkenylCOOH, C 3 -C 8 cycloalkylCOOH, and CONR 11 R 11 ; each R 10 is independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, and phenyl; each R 11 is independently hydrogen, or C 1 -C 6 alkyl; or a pharmaceutically acceptable salt thereof.