Patent ID: 7247701

Claim:
A method for preparing a compound represented by formula 5: comprising the steps of: (a) converting a compound represented by formula 1 to a compound represented by formula 2: (b) reacting the compound of formula 2 with an amine derivative represented by formula 3 and an organoboron compound represented by formula 4: thereby forming the compound represented by formula 5, wherein: R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, allyl, alkenyl, aryl, heteroaryl, acyl, sulfonyl, amino, alkylamino, dialkylamino, acylamino, sulfonylamino, and alkoxy, provided that R 1 and R 2 can be connected together forming a ring; or R 2 is a group represented by the following formula: wherein: A 1 and A 2 are independently selected from the group consisting of hydrogen, alkyl, allyl, alkenyl, aryl, heteroaryl, acyl, sulfonyl, amino, alkylamino, dialkylamino, acylamino, sulfonylamino, alkoxy, an amino acid and a peptide; A 3 is alkyl, aryl, heteroaryl, allyl, alkenyl, alkynyl, or allenyl; and R 1 , A 1 , A 2 and A 3 are optionally connected to form one or more rings; Rw is hydrogen, alkyl, aryl, or heteroaryl; Ra and Rb are independently selected from the group consisting of hydrogen, alkyl, allyl, benzyl, aryl, heteroaryl, acyl, sulfonyl, amino, alkylamino, dialkylamino, acylamino, sulfonylamino, and alkoxy, provided that Ra and Rb can be joined together forming a ring; or Ra is hydrogen, alkyl, allyl, alkenyl, aryl, heteroaryl, acyl, sulfonyl, amino, alkylamino, dialkylamino, acylamino, sulfonylamino, or alkoxy and Rb is wherein R 12 is selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, heteroaryl, amino, alkylamino, dialkylamino, hydroxyamino, alkoxyamino, hydroxyl, alkoxy, aryloxy and heteroaryloxy; R 3 and R 11 are independently alkyl, aryl, heteroaryl, allyl, alkenyl, alkynyl, or allenyl; provided that Ra, R 11 and R 12 can be connected together forming one or more rings and X and Y are independently selected from the group consisting of hydroxy, alkoxy, aryloxy, amino, alkylamino, and dialkylamino, provided that X and Y can be joined together forming a ring.