Patent ID: 6884419

Claim:
A fusion polypeptide which comprises a human granulocyte colony stimulating factor polypeptide and c-mpl ligand polypeptide and has no mouse IL-3 activity as measured by inability to stimulate growth of Ba/F3 cells, wherein the polypeptide comprises the amino acid sequence shown in SEQ ID NO:1 or an amino acid sequence in which the amino acid nos. 155 to 328 of the amino acid sequence shown in SEQ ID NO:1 Is replaced by an amino acid sequence of SEQ ID NO:39 or by an amino acid sequence in which the amino acid nos. 155 to 328 of the amino acid sequence shown in SEQ ID NO:1 is replaced by an amino acid sequence of SEQ ID NO:46 having a set of substitutions selected from the group consisting of those of Table 2 a) to j) and l).