Patent ID: 7141540

Claim:
A cyclodextrin grafted biocompatible polymer having the formula 1: wherein P is a biocompatible hydrophilic polymer backbone having a molecular weight range from 2,000 to 1,000,000 Daltons; R′ is H or a targeting moiety; X is a linker having the formula -Q-Z-Q′- wherein Q is covalently bonded to the hydrophilic polymer backbone either directly or by means of a pendant alkyl or other functional group and Q′ is covalently bonded to the cylodextrin at the 2, 3 or 6 position thereby replacing either an OR 1 , an OR 2 or an OR 3 group respectively; Q and Q′ are independently members selected from the group consisting of NR 4 , S, O, CO, CONH, and COO; Z is a member selected from the group consisting of an alkylene disulfide, [—(CH 2 ) a S—S(CH 2 ) a —], an alkylene [—(CH 2 ) a —], an alkylene oxide (—[(CH 2 ) a O] b (CH 2 ) a —), or a peptide linker, where a is an integer of 1 to 10 and b is an integer of 1 to 20; R 1 , R 2 , R 3 and R 4 are independently members selected from the group consisting of H, alkyl (C n′ H 2n′+1 ), alkenyl (C n′+1 H 2(n′+1)−1 ) or acyl (C n′ H 2n′+1 CO) where n′ is an integer of 1 to 16; q is an integer of 5, 6 or 7; and w is an integer such that each biocompatible hydrophilic polymer backbone contains between 1.5 and 30 cyclodextrin moieties per 20 KD of biocompatible hydrophilic polymer backbone.