Patent ID: 7253319

Claim:
A compound of the formula wherein R is selected from the groups consisting of the radicals defined by formulas (a) through (d) where the dashed line in a ring represents a bond, or absence of a bond with the proviso that one and only one dashed line in the ring represents a bond; a * denotes a ring carbon to which the chalcone oxime group is attached; X is (R 5 ) r -substituted alkenyl of 1–6 carbons and 1 or 2 double bonds, (R 5 ) r -substituted alkynyl of 1–6 carbons and 1 or 2 triple bonds, (R 5 ) r -phenyl, (R 5 ) r -naphthyl, (R 5 ) r -heteroaryl where the heteroaryl group has 1 to 3 heteroatoms selected from the group consisting of O, S and N; Y is a phenyl or naphthyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl and heteroaryl groups being optionally substituted with one or two R 4 groups; m is an integer having the values 0 to 5; n is an integer having the values 0 to 3; p is an integer having the values 0 to 2; r is an integer having the values 0 to 5; R 1 is independently alkyl of 1 to 6 carbons, F, Cl, Br or I; R 2 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, OH, SH, alkoxy having 1 to 6 carbons, alkylthio having 1 to 6 carbons, NH 2 , C 1-6 alkylamino or di(C 1-6 alkyl)amino; R 3 is H or alkyl of 1 to 10 carbons; R 4 is independently halogen, alkyl of 1 to 10 carbons, fluoro substituted alkyl of 1 to 6 carbons, alkoxy of 1 to 10 carbons, or alkylthio of 1 to 10 carbons; R 5 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, OH, SH, alkoxy having 1 to 6 carbons, alkylthio having 1 to 6 carbons, NH 2 , C 1-6 alkylamino or di(C 1-6 alkyl)amino; A is (CH 2 ) q where q is 0–5, lower branched chain alkyl having 3–6 carbons, cycloalkyl having 3–6 carbons, alkenyl having 2–6 carbons and 1 or 2 double bonds, alkynyl having 2–6 carbons and 1 or 2 triple bonds; B is COOH or a pharmaceutically acceptable salt thereof, COOR 8 , CONR 9 R 10 , —CH 2 OH, CH 2 OR 11 , CH 2 OCOR 11 , CHO, CH(OR 12 ) 2 , CHOR 13 O, —COR 7 , CR 7 (OR 12 ) 2 , CR 7 OR 13 O, or tri-lower alkylsilyl, where R 7 is an alkyl group of 1 to 6 carbons, cycloalkyl of 3 to 5 carbons, or alkenyl group containing 2 to 5 carbons, R 8 is an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, CH 2 OCH 3 or CH 2 OCH 2 OOC 1-6 alkyl, or R 8 is phenyl or C 1-6 alkylphenyl, R 9 and R 10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5–10 carbons, or phenyl or C 1-6 alkylphenyl, R 11 is alkyl of 1 to 6 carbons, phenyl or C 1-6 alkylphenyl, R 12 is alkyl of 1 to 6 carbons, and R 13 is divalent alkyl radical of 2–5 carbons, or a pharmaceutically acceptable salt of said compound.