Patent ID: 7939098

Claim:
A composition for transmucosal delivery of a pharmacologically active agent to a systemic circulation through a vaginal, nasal or buccal mucosa, said composition consisting essentially of said pharmacologically active agent, a non-ionizable glycol ether, a lipophilic or hydrophilic carrier, and a mucoadhesive agent, wherein said pharmacologically active agent is a peptide or protein selected from the group consisting of vasopressin, leuprolide, somatostatin, oxytocin, abarelix, calcitonin, bivalirudin, integrilin, natrecor, gastrin G17, ziconotide, cereport, interleukin and humanized antibodies having a partition coefficient logP<2.5, said agent present in amount from about 0.1 to about 200 mg; wherein said non-ionizable glycol derivative is selected from the group consisting of ethoxydiglycol, polyoxyethylene lauryl ether, polyoxyethylene monooleyl ether, polyoxyethylene nonylphenol, polyoxyethylene octylphenol ether, polyoxyethylene cholesterol ether, polyoxyethylene soya sterol ether, or a combination thereof, present from about 0.5 to about 25%, by weight; wherein said lipophilic carrier is a semi-synthetic glycerides of saturated fatty acid of 8-18 carbon chain present from about 60 to about 90%, by weight; wherein the hydrophilic carrier is a polyethylene glycol of from about 200 to about 8000 molecular weight selected from the group consisting of polyethylene glycol (PEG) 8000, PEG 600, PEG 4000, PEG 3350, PEG 1500, PEG 400, PEG 200 or a mixture thereof present in about 50 to about 90%, by weight; wherein said mucoadhesive agent is a cellulose derivative, alginate, pectin, polyacrylic acid, hyaluronic acid, polyvinyl alcohol, polyvinyl pyrrolidone, polycarbophil or carbopol present in from about 0.05 to about 25%, by weight.