Patent ID: 7625859

Claim:
An isolated polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOS: 14, 19-28, and fragments thereof of about 50 to 79 contiguous residues in length, wherein the polypeptide binds to the extracellular domain (ECD) of HER-2 with an affinity binding constant of at least 10 8 M −1 , and wherein the polypeptide comprises: with respect to said fragments of SEQ ID NO: 14, at least one of the position 6 Pro and the position 73 Asp; with respect to said fragments of SEQ ID NO: 19, the position 2 Ser; with respect to said fragments of SEQ ID NO:20, the position 5 Pro; with respect to said fragments of SEQ ID NO:21, both the position 6 Leu and the position 73 Asp; with respect to said fragments of SEQ ID NO:22, the position 16 Gln; with respect to said fragments of SEQ ID NO:23, the position 18 Leu; with respect to said fragments of SEQ ID NO:24, the position 21 Asp, Ala or Val; with respect to said fragments of SEQ ID NO:25, the position 36 Ile; with respect to said fragments of SEQ ID NO:26, the position 54 Arg; with respect to said fragments of SEQ ID NO:27, the position 64 Leu; or with respect to said fragments of SEQ ID NO:28, both the position 6 Pro and the position 73 Asn.