Patent ID: 8501724

Claim:
A compound of Formula (I) having the structure: wherein: L a is a bond, —CH 2 —, —CH(OH)—, —C(O)—, —CH 2 O—, —OCH 2 —, —SCH 2 , —CH 2 S—, —N(R 21 )—, —N(R 21 )C(O)—, —C(O)N(R 21 )—, —N(R 21 )C(O)N(R 21 )—, —O—, —S—, —S(O)—, —S(O) 2 —, —N(R 21 )S(O) 2 —, or —S(O) 2 N(R 21 )—; Ar is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl; R 3 is optionally substituted C 3 -C 6 alkyl, substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —(C═O)C 1 -C 6 alkyl, —(C═O)OR 4 , —(C═O)NR 4 R 4 , —(C═O)SR 4 , -G-X, or optionally substituted aryl, or optionally substituted heteroaryl; X is optionally substituted cycloalkyl; optionally substituted heterocycloalkyl; optionally substituted aryl, optionally substituted heteroaryl, —OR 4 , —SR 4 , or —NR 4 R 4 ; each R 4 is each independently H, C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 3 -C 6 cycloalkyl, or C 2 -C 6 heterocycloalkyl; Y is an optionally substituted group selected from among alkyl, heteroalkyl, cycloalkyl, aryl, and heteroaryl; Z is C(═O), OC(═O), N(R 21 )C(═O), C(═S), S(═O) x , OS(═O) x , or N(R 21 )S(═O) x , where x is 1 or 2; each R 24 is each independently halogen, —CN, —NO 2 , —OH, —OCF 3 , —OCH 2 F, —OCF 2 H, —CF 3 , —SR 21 , —N(R 21 )S(═O) 2 R 23 , —S(═O) 2 N(R 21 )(R 22 ), —S(═O)R 23 , —S(═O) 2 R 23 , —C(═O)R 23 , —OC(═O)R 23 , —CO 2 R 21 , —N(R 21 )(R 22 ), —C(═O)N(R 21 )(R 22 ), —N(R 21 )C(O)R 23 , —N(R 21 )C(═O)OR 22 , —N(R 21 )C(═O)N(R 21 )(R 22 ), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted heteroalkyl, or substituted or unsubstituted heterocycloalkyl; or substituted or unsubstituted cycloalkyl; R 21 and R 22 are each independently H, substituted or unsubstituted C 1 -C 6 alkyl, or substituted or unsubstituted C 3 -C 8 cycloalkyl; R 23 is each independently substituted or unsubstituted C 1 -C 6 alkyl, or substituted or unsubstituted C 3 -C 8 cycloalkyl; n is 0-4; p is 0-2; R 6 is H or L-J-W; R 7 and R 8 are independently H or L-J-W; or R 7 and R 8 taken together form a bond; L and J are each independently a bond, substituted or unsubstituted C 1 -C 6 alkylene, substituted or unsubstituted C 3 -C 6 cycloalkylene, substituted or unsubstituted C 1 -C 6 heteroalkylene, substituted or unsubstituted C 2 -C 7 heterocycloalkylene, substituted or unsubstituted C 6 -C 12 arylene, substituted or unsubstituted C 3 -C 12 heteroarylene, —CO—, —O—, or —S—; W is H, or NR 25 R 26 ; R 25 and R 26 are each independently H, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 2 -C 7 heterocycloalkyl, substituted or unsubstituted C 6 -C 12 aryl, or substituted or unsubstituted C 3 -C 12 heteroaryl; and, or pharmaceutically acceptable solvates, pharmaceutically acceptable salts, or pharmaceutically acceptable prodrugs thereof.