Patent ID: 6858739

Claim:
A compound of Formula II wherein: R 3 is NHR a , where R a is H, C 1 -C 4 alkyl, C 3 -C 8 cycloalkyl, phenyl, C 2 -C 6 heteroaryl, benzyl, CH 2 —(C 2 -C 6 heterocyclic radical), CONR b , CSNR b , SO 2 R b , SO 2 T, CONR b T, CSNR b T, T is C 1 -C 18 alkyl, phenyl, or C 3 -C 6 heterocyclic radical; and R b is H, C 1 -C 4 alkyl, phenyl, benzyl, C 1 -C 6 alkoxy, C 1 -C 6 alkanoic acid alkyl ester; C 1 -C 6 -alkylamino carbarnate, 1-phenethyl, 2-phenethyl, aminosulfonylphenyl, an amino acid radical selected from serine, phenylalanine, histidine, tryptophan, or tyrosine wherein hydroxy or carboxy groups may be protected or unprotected linked by the amino nitrogen or C 2 -C 6 heterocyclic radical; R 4 is selected from methoxy, ethoxy, thiomethoxy, fluoro, chloro, methyl, and ethyl; (C 1 -C 4 alkyl)oxycarbonyl, (C 3 -C 8 cycloalkyl)-oxycarbonyl, (C 3 -C 8 cycloalkyl)-(C 1 -C 4 alkyl)oxycarbonyl, or (C 6 -C 10 aryl)oxycarbonyl; R 5 is H, [phenyl(C 1 -C 4 alkyl)]oxycarbonyl, (C 1 -C 4 alkyl)oxycarbonyl, (C 3 -C 8 cycloalkyl)oxycarbonyl, (C 3 -C 8 cycloalkyl)-(C 1 -C 4 alkyl)oxycarbonyl, or (C 6 -C 10 aryl)oxycarbonyl; R 6 is H or C 1 -C 6 alkyl; each X is independently H, halo, C 1 -C 4 alkyl, C 1 -C 4 alkenyl, C 1 -C 4 alkynyl, hydroxyl, C 1 -C 4 hydroxyalkyl, amino, (amino)sulfonyl, N-acetyl, O-acetyl, C 1 -C 4 thioalkyl, C 1 -C 4 alkoxy, COOR 6 , SO 3 Na, SO 3 H, SO 2 NH 2 , cyano, phosphonic acid, phosphonic acid esters, C 1 -C 6 alkanoic acid, C 1 -C 6 alkanoic acid caters, carbamic acid, carbamic acid esters, CH 2 NH 2 , acetyl, di(C 1 -C 4 alkyl)amino, or nitro; or a pharmaceutically acceptable salt thereof.