Patent ID: 7985755

Claim:
A 2,4-diaminoquinazoline compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein U is —O—; R 2 and R 3 are independently selected in each occurrence from H and lower alkyl; n is 0, 1, 2, or 3; X is selected from the group consisting of N and CH; Y is selected from the group consisting of N, CH, C(OH) and N→O; R 10 , R 11 , R 12 and R 13 are independently selected from H and lower alkyl, or, taken together, R 10 and R 11 or R 12 and R 13 are ═O; Q is selected from the group consisting of —CH 2 —, —C(═O)—, —CH 2 (C═O)—, —SO 2 —, —CR 14 R 15 —, —C(═O)CH 2 S— and a direct bond, wherein R 14 and R 15 are independently selected from hydrogen and lower alkyl; and R 1 is selected from the group consisting of H, alkyl, alkoxy, carbocycle, heterocyclyl, fluoroalkyl, alkoxyalkyl, substituted carbocycle and substituted heterocyclyl; wherein substituted carbocycle or heterocyclyl refers to a carbocycle or heterocyclyl wherein up to three H atoms are replaced with a substituent independently selected from the group consisting of halogen, haloalkyl, hydroxy, loweralkoxy, carboxy, carboalkoxy, carboxamido, cyano, carbonyl, nitro, amino, alkylamino, dialkylamino, mercapto, alkylthio, sulfoxide, sulfone, acylamino, amidino, phenyl, benzyl, halobenzyl, heteroaryl, phenoxy, benzyloxy, heteroaryloxy, benzoyl, halobenzoyl, and loweralkylhydroxy.