Patent ID: 8088726

Claim:
A method for producing a sustained-release microsphere, which comprises mixing an aqueous solution containing a compound represented by the general formula: 5-oxo-Pro-His-Trp-Ser-Tyr-Y-Leu-Arg-Pro-Z (SEQ ID NO: 1) wherein Y represents DLeu, DAla, DTrp, DSer (tBu), D2Nal or DHis (ImBzl) and Z represents NH—C 2 H 5 or Gly-NH 2 and acetic acid in a molar amount of 1.5 to about 5 times that of the compound with a solution of a lactic acid-glycolic acid polymer in a low water-soluble organic solvent to obtain a W/O type emulsion, and then drying the emulsion to obtain microspheres.