Patent ID: 7674886

Claim:
A compound of the formula: wherein: n=0 or 1; R 1 and R 2 are independently selected from hydrogen, ═O, with the proviso that both are not ═O, —(CH 2 ) m —Z where m is 0-10 and Z represents a conjugation group or targeting moiety, and —(CH 2 ) m —W where m is 0-10 and W represents a hydrolyzable group, or R 1 and R 2 are taken together to form a cyclic anhydride or a benzene ring, wherein the benzene ring is optionally substituted with a carboxyl group; R 3 is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m —Z or —(CH 2 ) m —W; R 4 and R 5 are attached at one or more of the ring positions and are independently selected from hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m —Z and —(CH 2 ) m —W; R 6 and R 7 are independently selected from hydrogen with the proviso that both are not hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m —Z, —(CH 2 ) m —W— and where Q represents a multivalent acid functionality group able to coordinate with metal ions, and p=0 to 1; R 12 and R 13 are independently selected from hydrogen, hydroxyl, carboxyl, phosphoric, and hydrocarbon radicals having from 1-10 carbon atoms, and physiologically acceptable salts of the acid radicals; X, X′, and Y and Y′ are independently selected from carbon and nitrogen to independently form 5 member aromatic rings wherein the remaining ring atoms are carbon; A and A′ are independently selected from sulfur, nitrogen and oxygen, where sulfur may bear a hydrogen or a sulfur protecting group, or where A and A′ are both sulfur, A and A′ may be joined together by a bond; where an oxygen or a nitrogen may bear a hydrogen; or where A or A′ is nitrogen, A may bear R 8 or R 10 or both and A′ may bear R 9 or R 11 or both, wherein R 8 , R 9 , R 10 and R 11 are independently selected from lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m —Z, —(CH 2 ) m —W and or R 8 and R 10 may be joined to form a cyclic anhydride or R 9 and R 11 may be joined to form a cyclic anhydride; or when A and A′ are both nitrogen, R 10 and R 11 are joined to form T, where T is and n is 0 to 1, and R 1 ′ and R 2 ′ are independently selected from hydrogen, ═O, with the proviso that both are not ═O, —(CH 2 ) m —Z, or R 1 ′ and R 2 ′ are taken together to form a cyclic anhydride or a benzene ring, wherein the benzene ring is optionally substituted with a carboxyl group; and R 3 ′ is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH 2 ) m —Z or —(CH 2 ) m —W; and the compound has at least one Z, W or Q.