Patent ID: 8232286

Claim:
A compound of formula 1; with the proviso that the circular line designated A denotes an aromatic system; wherein Y denotes nitrogen; Z denotes nitrogen; j denotes 3; k denotes 0; R a denotes H, COR 8 , NR 9 R 10 , NO 2 , OR 8 , SR 11 , SOR 11 , SO 2 R 11 , NHCO—C 1-6 -alkyl-NH 2 , or a group selected from among C 1-6 -alkyl, C 2-6 -alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl, C 1-6 -haloalkyl, aryl, C 7-11 -aralkyl, spiro, het, hetaryl and CH 2 —O-aryl, which may optionally be substituted; R 8 denotes C 1-6 -alkyl, C 3-6 -cycloalkyl, NH 2 , hetaryl or aryl, optionally substituted by one or more halogens or C 1-4 -alkyl; R 9 denotes H, COOR 12 , CONHR 12 or C 1-6 -alkyl, optionally substituted by one or more COOH, N(C 1-6 -alkyl) 2 or het, optionally substituted by one or more C 1-6 -alkyl; or R 9 denotes het, optionally substituted by one or more C 1-4 -alkyl; R 10 denotes H, C 1-6 -alkyl, CO—C 1-6 -alkyl or C 2-6 -alkynyl; R 11 denotes C 1-6 -alkyl, optionally substituted by one or more N(C 1-4 -alkyl) 2 ; R 12 denotes C 1-6 alkyl; R b denotes R 4 , OR 4 , —CH 2 OR 4 , COR 4 , COOR 4 , CONR 4 R 5 , NR 4 R 5 , NR 5 COR 4 , NR 5 COOR 4 , NR 5 CONR 4 R 5 , NR 5 SOR 4 or NR 5 SO 2 R 4 ; R 4 and R 5 are independently selected from H, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkylene-OH, C 2-6 -alkenyl, C 7-11 -aralkyl, C 2-4 -alkenyl-aryl, C 2-4 -alkynyl-aryl, C 1-4 -alkyl-hetaryl, C 2-4 -alkenyl-hetaryl, C 2-4 -alkynyl-hetaryl, C 2-6 -alkynyl, optionally substituted by Si(C 1-4 -alkyl) 3 , or R 4 denotes a group selected from among aryl, het or hetaryl and optionally substituted by C 1-4 -alkyl; or R 4 and R 5 together form a five-, six- or seven-membered ring consisting of carbon atoms and optionally a heteroatom selected from among oxygen, nitrogen and sulphur; R c denotes NHR 6 or a group selected from among wherein B denotes a bond, C 1-6 -alkyl, C 2-6 -alkenyl or C 2-6 -alkynyl; R 6 denotes H or a group selected from among C 1-4 -alkyl, C 2-4 -alkenyl, C 2-4 -alkynyl, C 3-6 -cycloalkyl, C 3-6 -cycloalkenyl, het, aryl, hetaryl optionally substituted by one or more groups R 6.1 ; R 6.1 denotes halogen, CF 3 , OH, CN, OMe or SO 2 (C 1-4 -alkyl); R 7 denotes H, C 1-4 -alkyl, C 2-4 -alkenyl, C 2-4 -alkynyl, C 3-6 -cycloalkyl, NR 7.1 R 7.2 , OR 7.2 , SR 7.2 , hetaryl or het, optionally substituted by C 1-4 -alkyl or CONH 2 ; R 7.1 denotes H, C 1-6 -alkyl, (CH 2 ) 1-4 R 7.1.1 or COObutyl; R 7.2 denotes H, C 1-6 -alkyl, optionally substituted by one or more OH; R 7.1.1 denotes NR 7.1.1.1 R 7.1.1.2 , het or 1-imidazolyl, 2-(N-ethylpyrrolidine); R 7.1.1.1 denotes H or C 1-6 -alkyl; R 7.1.1.2 denotes H or C 1-6 -alkyl; or a pharmacologically acceptable salt thereof.