Patent ID: 7423056

Claim:
A compound of the formula where X is S or O; m is 1 or 2; n is 1 or 2; m+n is ≧2; Y is CR 3 R 3a and Z is a covalent bond or CR 4 R 4a , Y is a covalent bond and Z is CH 2 CH 2 or CR 4 R 4a or Y or CH 2 CH 2 and Z is a covalent bond; R 1 and R 2 are independently selected from the group consisting of H, halogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, perhaloalkyl, CN, OR 5 , SR 5 , N(R 5 ) 2 , COOR 5 , COR 6 , CON(R 5 ) 2 , NR 5 COR 6 , NR 5 CO 2 R 6 , NR 5 SO 2 R 6 , aryl, heteroaryl, C 1-10 alkylaryl, and C 1-10 alkylheteroaryl, wherein said aryl or heteroaryl can be optionally substituted; R 1 and R 2 taken together can form a 5- or 6-member aryl or heteroaryl ring that is optionally substituted; R 3 is selected from the group consisting of H, halogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, perhaloalkyl, CN, OR 5 , SR 5 , N(R 5 ) 2 , OCOR 6 , COOR 5 , COR 6 , CON(R 5 ) 2 , NR 5 COR 6 , NR 5 CO 2 R 6 , NR 5 SO 2 R 6 , aryl, heteroaryl, C 1-10 alkylaryl, and C 1-10 alkylheteroaryl, wherein said aryl or heteroaryl can be optionally substituted; R 3a is H or R 3 and R 3a taken together are —CH 2 CH 2 — or carbonyl; R 4 is selected from the group consisting of H, halogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, perhalo alkyl, CN, OR 5 , SR 5 , N(R 5 ) 2 , OCOR 6 , COOR 5 , CON, CON(R 5 ) 2 , NR 5 COR 6 , NR 5 CO 2 R 6 , NR 5 SO 2 R 6 , aryl, heteroaryl, C 1-10 alkylaryl, and C 1-10 alkylheteroaryl, wherein said aryl or heteroaryl can be optionally substituted; R 4a is H or R 4 and R 4a taken together are —CH 2 CH 2 — or carbonyl; R 5 is selected from the group consisting of H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, perhaloalkyl, C 1-10 alkyl-O—C 1-10 alkyl, aryl, heteroaryl, C 1-10 alkyl-O-aryl, C 1-10 alkyl-O-heteroaryl, C 1-10 alkylaryl, and C 1-10 alkylheteroaryl, wherein said aryl or heteroaryl can be optionally substituted; R 6 is selected from the group consisting of C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, perhaloalkyl, C 1-10 alkyl-O—C 1-10 alkyl, aryl, heteroaryl, C 1-10 alkyl-O-aryl, C 1-10 alkyl-O-heteroaryl, C 1-10 alkylaryl, and C 1-10 alkylhetroaryl, wherein said aryl or heteroaryl can be optionally substituted, and R 7 is selected from the group consisting of H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkyl-O—C 1-10 alkyl, COOR 5 , COR 6 , CON(R 5 ) 2 , aryl, heteroaryl, C 1-10 alkyl-O-aryl, C 1-10 alkyl-O-heteroaryl, C 1-10 alkylaryl, and C 1-10 alkylheteroaryl, wherein said aryl or heteroaryl can be optionally substituted, and the pharmaceutically acceptable salts thereof.