Patent ID: 7317114

Claim:
A process to obtain synthetic lignan derivatives from the formula: comprising the following steps: a) reaction of (−)-cubebin with pyridinium chlorine chromate (PCC) in dry dichloromethane under an inert atmosphere (N 2 ) for 24 hours at a temperature of about −6° C. and under constant agitation; b) isolation of (−)-hinokinin having the structural formula: wherein the isolation of (−)-hinokinin is prepared by: 1) pouring the reaction medium in a chromatographic column under vacuum with sinterized plaque n° 2 containing monohydrated MgSO 4 by providing vacuum filtration and collecting a sample; 2) submitting the sample to a chromatographic column with silica gel 60 and the following solvent gradient system: 100% hexane, 8:2 hexane:ethyl acetate, 7:3 hexane:ethyl acetate, 6:4 hexane:ethyl acetate, 100% ethyl acetate and 100% methanol; and c) transferring the organic phase to a collecting flask followed by purification under preparative circular chromatography [CCP] (CROMATOTRON).