Patent ID: 7858769

Claim:
A multifunctional siNA molecule of Formula I: 5′- p -XZX′-3′ 3′-Y′ZY- p -5′ wherein each 5′-p-XZX′-3′ and 5′-p-YZY′-3′ independently comprise an oligonucleotide of length between 24 and 38 nucleotides, XZ comprises a nucleic acid sequence that is complementary to a first target nucleic acid sequence, YZ comprises an oligonucleotide comprising nucleic acid sequence that is complementary to a second target nucleic acid sequence, Z comprises nucleotide sequence of length 1 to 24 nucleotides that is complementary between regions XZ and YZ, X comprises nucleotide sequence of length 1 to 21 nucleotides that is complementary to nucleotide sequence present in region Y′, Y comprises nucleotide sequence of length 1 to 21 nucleotides that is complementary to nucleotide sequence present in region X′, p comprises a terminal phosphate group that can independently be present or absent, and wherein each said XZ and said YZ are independently of length sufficient to stably interact with said first and said second target nucleic acid sequence, respectively, or a portion thereof.