Patent ID: 7790726

Claim:
A compound having Formula I: or pharmaceutically acceptable salts and N-oxides thereof; wherein each R 1 is independently selected from the group consisting of —CO 2 R a and C 1-8 alkyl, wherein R a is selected from the group consisting of hydrogen, and C 1-8 alkyl; the subscript m is 0 or 1; R 2c is halogen or —OR c ; R 2d is halogen or —OR c ; R 2a , R 2b and R 2e at each occurrence are each independently selected from the group consisting of hydrogen, halogen, and —OR c , wherein each R c is independently selected from hydrogen, and C 1-8 alkyl; B represents a benzoxazoline ring system linked through its nitrogen atom to the remainder of the molecule, and is further substituted with 0 to 4 R 3 substitutents, and at each occurrence, R 3 is independently selected from the group consisting of hydrogen, halogen, —OR f , —CN, unsubstituted C 1-6 alkyl and an oxadiazole ring, or any two R 3 substituents attached to the same atom on B are taken together to form ═O, wherein each R f is independently selected from hydrogen, and C 1-8 alkyl, wherein the aliphatic portions of R f , are optionally further substituted with a member selected from the group consisting of —OH, —CO 2 H, —CO 2 R o , and —NH 2 , wherein R o is unsubstituted C 1-6 alkyl; L 1 is CH 2 ; the symbol U is N; L 2 is a direct bond; and the subscript n is 1.