Patent ID: 7470669

Claim:
An isolated polypeptide comprising: a) a leptin polypeptide fragment that modulates an activity of the Lipolysis Stimulated Receptor (LSR) and comprises at least 22 but not more than 50 contiguous amino acids of SEQ ID NO: 32 and contains amino acid residues 117-138 of SEQ ID NO: 32, wherein said activity of the LSR is selected from the group consisting of binding of lipoproteins, uptake of lipoproteins, degradation of lipoproteins, binding of leptin, uptake of leptin, and degradation of leptin; b) a leptin polypeptide fragment that modulates an activity of the LSR and comprises at least 22 but not more than 40 contiguous amino acids of SEQ ID NO: 32 and contains amino acid residues 117-138 of SEQ ID NO: 32, wherein said activity of the LSR is selected from the group consisting of binding of lipoproteins, uptake of lipoproteins, degradation of lipoproteins, binding of leptin, uptake of leptin, and degradation of leptin; c) a leptin polypeptide fragment that modulates an activity of the LSR and comprises at least 22 but not more than 30 contiguous amino acids of SEQ ID NO: 32 and contains amino acid residues 117-138 of SEQ ID NO: 32, wherein said activity of the LSR is selected from the group consisting of binding of lipoproteins, uptake of lipoproteins, degradation of lipoproteins, binding of leptin, uptake of leptin, and degradation of leptin; d) a leptin polypeptide fragment that modulates an activity of the LSR, said leptin polypeptide fragment comprising an amino acid sequence that is at least 85% identical to a polypeptide that comprises at least 22 but not more than 50 contiguous amino acids of SEQ ID NO: 32 wherein said fragment contains amino acid residues 117-138 of SEQ ID NO: 32, wherein said activity of the LSR is selected from the group consisting of binding of lipoproteins, uptake of lipoproteins, degradation of lipoproteins, binding of leptin, uptake of leptin, and degradation of leptin; e) a leptin polypeptide fragment that modulates an activity of the LSR, said leptin polypeptide fragment comprising an amino acid sequence that is at least 95% identical to a polypeptide that comprises at least 22 but not more than 50 contiguous amino acids of SEQ ID NO: 32 wherein said fragment contains amino acid residues 117-138 of SEQ ID NO: 32, wherein said activity of the LSR is selected from the group consisting of binding of lipoproteins, uptake of lipoproteins, degradation of lipoproteins, binding of leptin, uptake of leptin, and degradation of leptin; or f) a leptin polypeptide fragment of at least 22 but not more than 50 contiguous amino acids of SEQ ID NO:32 wherein said fragment contains amino acid residues 117-138 of SEQ ID NO: 32.