Patent ID: 7705153

Claim:
A compound represented by the structural formula II or a pharmaceutically acceptable salt thereof, wherein n is 1; X a is —C(R 13 ) 2 —; R a is R 6a -phenyl; R 1 is hydrogen, halogen, —OH, alkyl, hydroxyalkyl, alkoxy or alkoxyalkyl; R 2a is R 6a is 1 to 3 substituents independently selected from the group consisting of hydrogen, halogen, —CF 3 , CF 3 O—, —CN, —NHCOCF 3 , 5-membered heteroaryl and wherein Z is —O—, —NH— or —N(CH 3 )—; R 13 and R 16 are independently selected from the group consisting of hydrogen and alkyl; R 14 is alkyl, alkenyl, haloalkyl, hydroxy, hydroxyalkyl, —CN, —(CR 20 R 21 ) q —O-alkyl, —(CR 20 R 21 ) q —NR 20 R 24 , —(CR 20 R 21 ) q —N 3 , —(CR 20 R 21 ) q —C(O)-alkyl, —(CR 20 R 21 ) q —C(O)-phenyl, —(CR 20 R 21 ) q —COOR 20 , —(CR 20 R 21 ) q —C(O)NR 20 R 24 , —(CR 20 R 21 ) q —S(O) 0-2 —R 23 , —(CR 20 R 21 ) q —N(R 20 )—C(O)NR 20 R 24 , —(CR 20 R 21 ) q —N(R 20 )—C(O)OR 23 or —(CR 20 R 21 ) q —O—C(O)R 23 ; R 14a is hydrogen or alkyl; q is 0, 1, 2 or 3; R 15 and R 15a are each 1 or 2 substituents independently selected from the group consisting of H, halogen, OH, alkyl, alkoxy, —CF 3 , —OCF 3 , —CN, —C(O)R 25 , —COOR 25 , —S(O) 0-2 R 25 , —S(O) 0-2 CF 3 , —NR 20 R 24 , phenyl; R 20 and R 21 are independently selected from the group consisting of H and alkyl; R 23 is alkyl or phenyl; and R 24 is H, alkyl or R 12 -phenyl; provided that when R 14 is —(CR 20 R 21 ) q —NR 20 R 24 and R 24 is H, R 20 is alkyl.