Patent ID: 7160592

Claim:
A coating for a medical device having a body fluid-contacting surface for contacting blood or other body fluids, the coating comprising: a silane derivative covalently bonded to the surface of a medical device, said silane derivative containing hydroxyl or amino functional groups; a layer of lactone polymer chains grown on the hydroxyl or amino functional groups of the silane derivative through in-situ ring opening graft polymerization of lactone monomers, said polymerization initiated by the said hydroxyl or amino functional groups of the silane derivative covalently bonded to the surface of a medical device, said lactone polymer chains and said silane derivative together forming a grafted lactone polymer layer; and at least one polyester polymer/biologically active agent layer deposited on the grafted lactone polymer layer, wherein at least the first of the deposited polymer/biologically active agent layers is chemically compatible with the grafted lactone polymer layer to allow for entanglement of said deposited polyester polymer chains with the chains of said grafted lactone polymer chains for strong adhesion.