Patent ID: 7642275

Claim:
A compound consisting of the formula: or steroisomers, or pharmaceutically acceptable salts thereof, wherein: n is 4; p is 0, 1, 2, 3, or 4; A 1 is selected from the group consisting of (C 3-12 )cycloalkylene, hetero(C 3-12 )cycloalkylene, arylene, and heteroarylene, each unsubstituted or substituted; L is a linker consisting of a backbone chain of 1 to 10 carbon atoms, and may be optionally substituted with a substituent selected from the group consisting of halo, halo(C 1-6 )alkyl, amino, nitro, cyano, thio, (C 1-6 )alkyl, (C 3-7 )cycloalkyl, (C 1-6 )alkyl(C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-6 )alkyl, hetero(C 3-7 )cycloalkyl, (C 1-6 alkylhetero(C 3-7 )cycloalkyl, hetero(C 3-7 )cycloalkyl(C 1-6 )alkyl, (C 1-6 )heteroalkyl, aryl, (C 1-6 )alkylaryl, aryl(C 1-6 )alkyl, heteroaryl, (C 1-6 )alkylheteroaryl, heteroaryl(C 1-6 )alkyl, carbonyl(C 1-6 )alkyl, thiocarbonyl(C 1-5 )alkyl, sulfonyl(C 1-6 )alkyl, sulfinyl(C 1-6 )alkyl, and imino(C 1-6 )alkyl; Y 1 is selected from the group consisting NR 9 , O, and S; Z 1 is selected from the group consisting of O and S; R 4 is selected from the group consisting of hydrogen, halo, perhalo(C 1-10 )alkyl, amino cyano, nitro, thio, (C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, aryl(C 1-10 )alkyl, heteroaryl (C 1-5 )alkyl, (C 9-12 )bicycloaryl, hetero(C 8-12 )bicycloaryl, carbonyl (C 1-3 )alkyl, thiocarbonyl (C 1-3 )alkyl, sulfonyl (C 1-3 )alkyl, sulfinyl (C 1-3 )alkyl, imino (C 1-3 )alkyl, aryl, heteroaryl, hydroxy, alkoxy, aryloxy, heteroaryloxy, alkenyl, alkynyl, carbonyl, imino, sulfonyl, and sulfinyl, each substituted or unsubstituted; each R 6 is independently selected from the group consisting of hydrogen, halo, perhalo(C 1-10 )alkyl, amino, cyano, nitro, thio, (C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero( 3-12 )cycloalkyl, aryl(C 1-10 )alkyl, heteroaryl (C 1-5 )alkyl, (C 9-12 )bicycloaryl, hetero( 8-12 )bicycloaryl, carbonyl (C 1-3 )alkyl, thiocarbonyl (C 1-3 )alkyl, sulfonyl (C 1-3 )alkyl, sulfinyl (C 1-3 )alkyl, imino (C 1-3 )akyl, aryl, heteroaryl, hydroxy, alkoxy, aryloxy, heteroaryloxy, alkenyl, alkynyl, carbonyl, imino, sulfonyl, and sulfinyl, each substituted or unsubstituted; and R 9 is selected from the group consisting of hydrogen, (C 1-10 )alkyl, (C 3-12 )cycloalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl(C 1-5 )alkyl, aryl(C 1-10 )alkyl, heteroaryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 4-12 )bicycloaryl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, carbonyl (C 1-3 )alkyl, thiocarbonyl (C 1-3 )alkyl, sulfonyl (C 1-3 )alkyl, sulfinyl (C 1-3 )alkyl, imino (C 1-3 )alkyl, amino, aryl, heteroaryl, hydroxy, alkoxy, aryloxy, heteroaryloxy, carbonyl, imino, sulfonyl, and sulfinyl, each substituted or unsubstituted.