Patent ID: 7662971

Claim:
An inhibitor of fatty acid amide hydrolase represented by the following formula: A-B—C wherein A is an inhibition subunit in the form of an α-keto heterocyclic pharmacophore for inhibiting the fatty acid amide hydrolase, B is a linkage subunit, and C is a binding subunit wherein A-B—C is represented by the formula: wherein R 1 and R 2 are radicals independently selected from the group consisting of hydrogen, C1-C6 alkyl, aromatic ring, and heteroaromatic ring; with the proviso that R 1 and R 2 cannot both be hydrogen; the linkage subunit B is a linear chain of 3 to 9 carbon atoms for linking the inhibition subunit A and the binding subunit C and for enabling the binding subunit C to bind to the binding region on the fatty acid amide hydrolase, the linear skeleton having a first end and a second end, the first end being covalently bonded to the α-keto group of A, wherein the first end of B is an α-carbon with respect to the α-keto group of the inhibition subunit A, and then the α-carbon is optionally mono- or bis-functionalized with substituents selected from the group consisting of fluoro, chloro, hydroxyl, alkoxy, trifluoromethyl, and alkyl; and the binding subunit C is a π-bond containing radical having a π-unsaturation and being selected from a group consisting of aryl, alkynyl, and ring structures having at least one unsaturation, with or without one or more heteroatoms, the binding subunit C being covalently bonded to the second end of the linkage subunit B, the π-unsaturation within the π-bond containing radical being separated from the α-keto group of A by a sequence of no less than 3 and no more than 9 atoms bonded sequentially to one another, inclusive of the linear skeleton for enabling the π-unsaturation to bind to the binding region of the fatty acid amide hydrolase while the inhibition subunit A inhibits the fatty acid amide hydrolase.