Patent ID: 8889354

Claim:
A method for determining whether to continue a cancer therapy regimen for treating a hematological cancer in a patient comprising: a) measuring the level of expression of at least one nucleic acid sequence selected from the group consisting of sequences recognized by probesets of predictive marker or markers numbered 1-547 in Table 1A, 658-871 in Table 1B, 873-876 in Table 1B, 912-1062 in Table 2A, 1071-1079, 1081-1087, 1089-1093, 1095-1106, 1108-1185 in Table 2B, and/or 1203-1423 in Table 3 in a first patient sample comprising hematological tumor cells, wherein the sequences recognized by probesets of the predictive marker or markers: i) numbered 1-547 consist of SEQ ID NOs: 1-513, ii) numbered 658-871 and 873-876 consist of SEQ ID NOs:614-830, iii) numbered 912-1062 consist of SEQ ID NOs:866-1014, 434 and 733, iv) numbered 1071-1079, 1081-1087, 1089-1093, 1095-1106 and 1108-1185 consist of SEQ ID NOs:1023-1133, and v) numbered 1203-1423 consist of SEQ ID NOs:201, 398, 1091 and 1151-1365, thereby determining a baseline expression level of the predictive marker or markers; b) treating the patient with the cancer therapy regimen; c) measuring the level of expression of the at least one nucleic acid measured in step a) in a successive patient sample comprising hematological tumor cells; d) comparing the expression level in step c) to the baseline level in step a), thereby identifying whether expression in the successive sample includes a profile of expression of the predictive marker or markers; and e) continuing treatment of the hematological cancer if the expression profile of the predictive marker or markers in the successive sample demonstrates responsiveness, wherein the hematological cancer is multiple myeloma, wherein the hematological tumor cells are multiple myeloma tumor cells, and wherein the cancer therapy regimen is selected from the group consisting of proteasome inhibition therapy and glucocorticoid therapy.