Patent ID: 7507720

Claim:
A compound of general formula (I): including all stereoisomers and racemic mixtures thereof, a pharmaceutically acceptable salt of any of the compounds of general formula (I), wherein: in the general formula (I): R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 10 , are, independently of each other, either H, OH; ═O, and OR wherein R=optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl; R 9 , R 12 , R 11 , R 13 can be either a H, OH, OR wherein R=optionally substituted alkyl, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl; R 14 =optionally substituted alkyl group; R 3 =OR wherein R=optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl; represents an optional double bond, and excluding where simultaneously: R 1 ═R 2 ═R 4 ═R 5 ═R 6 ═R 7 ═R 8 ═R 9 ═R 10 ═R 11 ═R 12 ═R 13 ═H R 14 ═CH 3 no double bonds are present and (i) when the stereochemistry of C25 is S, R 3 =αOR wherein OR=acetate or R 3 =βOR wherein OR=acetate, tert-butyloxycarbonyloxy, or succinate; and (ii) when the stereochemistry of C25 is S, R 3 =αOR wherein OR=acetate or R 3 =βOR, wherein OR=acetate, propionate, isobutyrate, butyrate, tert-butyloxycarbonyloxy, valerate, isovalerate, isovalerate, caproate, iaocaproate, diethylacetate, octanoate, decanoate, laurate, myristate, palmitate, stearate, benzoate, phenylacetate, octanoate, cinnamate, p-nitrobenzoate, 3,5-dinitrobenzoate, p-cholorobenzoate, 2,4-dichlorobenzoate, p- bromobenzoate, m-bromobenzoate, p-methoxybenzoate, cyclopentylpropionate, furoate, succinate or phthalate; and excluding where simultaneously: R 4 ═R 5 ═R 6 ═R 9 ═R 10 ═R 11 ═R 12 ═R 13 ═H R 1 ═H or OCOCH 3 R 2 ═OCOCH 3 R 3 ═OCOCH 3 R 7 ═H, (═O), or OH R 8 ═H, OCOCH 3 , or (═O) R 14 ═CH 3 and no double bonds are present; and excluding where simultaneously: R 1 ═R 4 ═R 4 R 6 ═R 7 ═R 8 ═R 9 ═R 10 ═R 11 ═R 12═R 13 ═H R 2 ═βOR wherein OR═OCOOCH 2 CH 3 R 3 ═αOR wherein OR═OCOOCH 2 CH 3 ═R 14 ═CH 3 the stereochemistry of C25 is R and no double bonds are present; and excluding where simultaneously: R 1 ═R 2 ═R 5 ═R 6 ═R 7 ═R 9 ═R 10 ═R 11 ═R 12 ═R 13 ═H, R 3 ═β—OCOCH 3 and either (i) R 4 ═H and R 8 ═(═O); or (ii) R 4 ═β—OCOCH 3 and R 8 ═H R 14 ═CH 3 and no double bonds are present.