Patent ID: 7041685

Claim:
A compound having the Formula II or a pharmaceutically acceptable salt or prodrug thereof, wherein: Ar 1 is substituted aryl or substituted heteroaryl, wherein said substituents are selected from the group consisting of halo, C 1 -C 6 haloalkyl, C 6 -C 10 aryl, C 4 -C 7 cycloalkyl, C 2 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 6 -C 10 aryl(C 1 -C 6 )alkyl, C 6 -C 10 aryl(C 2 -C 6 )alkenyl, C 6 -C 10 aryl(C 2 -C 6 )alkynyl, C 1 -C 6 hydroxyalkyl, amino, ureido, cyano, C 1 -C 6 acylamino, hydroxy, thiol, C 1 -C 6 acyloxy, azido, C 1 -C 6 alkoxy and carboxy; Ar 3 is optionally substituted arylalkyl, aryloxy, phenoxymethyl, anilino, benzylamino, benzylideneamino, benzoylamino or Ar 2 , wherein Ar 2 is optionally substituted aryl or optionally substituted heteroaryl, wherein said substituents are selected from the group consisting of halo, C 1 -C 6 haloalkyl, C 6 -C 10 aryl, C 4 -C 7 cycloalkyl, C 2 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 6 -C 10 aryl(C 1 -C 6 )alkyl, C 6 -C 10 aryl(C 2 -C 6 )alkenyl, C 6 -C 10 aryl(C 2 -C 6 )alkynyl, C 1 -C 6 hydroxyalkyl, amino, ureido, cyano, C 1 -C 6 acylamino, hydroxy, thiol, C 1 -C 6 acyloxy, azido, C 1 -C 6 alkoxy and carboxy; with the provisos that: (a) when Ar 1 is substituted thienyl, then Ar 3 is other than phenyl substituted by chloro or trifluoromethyl; (b) when Ar 1 is substituted isoxazolyl, then Ar 3 is other than unsubstituted phenyl; (c) when Ar 1 is substituted pyrazolyl, then Ar 3 is other than pyridinyl substituted by trifluoromethyl and other than phenyl substituted by trifluoromethyl; and (d) when Ar 1 is substituted pyrrolyl, then Ar 3 is other than unsubstituted pyridinyl.