Patent ID: 8022177

Claim:
An isolated calcium channel gamma6 subunit peptide fragment comprising an N-terminal first transmembrane domain segment of at least 15 continuous amino acids of a rat, mouse, or human source; wherein the peptide fragment has a maximum total length of 15 to 40 amino acids, and wherein the segment comprises a Gx 2 x 3 x 4 G-like structural motif located near the cytoplasmic end of the first transmembrane domain, wherein the Gx 2 x 3 x 4 G-like motif is a x 1 x 2 x 3 x 4 x 5 in which x 1 and x 5 are each independently glycine or alanine or serine and wherein x 2 , x 3 , and x 4 are each independently selected from leucine, valine, phenylalanine, glycine, threonine, isoleucine, alanine and serine, and wherein said peptide fragment can reduce voltage dependent calcium current in a cell.