Patent ID: 8641903

Claim:
A method to extract out of an aqueous solution, concentrate or reformulate [18F] fluorides without any evaporation step, or without any azeotropic evaporation step, said method comprising: passing aqueous [18F] fluoride solution through a solid phase extraction column containing a modified non-ionic solid support (SS) wherein [18F] fluorides are trapped on the modified non-ionic solid support, optionally purging the modified non-ionic SS with a neutral solvent or flushing it with a gas to remove residual water, eluting the [18F] fluorides in an organic solvent or in a mixture of organic solvents for radiolabelling, wherein modification of a non-ionic SS has been performed prior to [18F] fluoride extraction, concentration or reformulation process, by causing adsorption on a SS of a trapping agent (TA) which is a cationic species that has the ability to trap the [18F] fluoride in an anion exchange process, forming a TA-[18F] species and wherein a couple SS-TA is selected in such a way that the TA is substantially able to remain on the modified non-ionic SS during transit of the aqueous [18F] fluoride solution through the solid phase extraction column, while being eluted in an organic solvent or in a mixture of organic solvents for radiolabelling.