Patent ID: 8541568

Claim:
A composition comprising at least three isolated siRNA molecules, wherein at least one isolated siRNA molecule (sense: 5′-CUGUAGACACACCCACCCACAUACA-3′ (SEQ ID NO: 10), antisense: 5′-UGUAUGUGGGUGGGUGUGUCUACAG-3′) (SEQ ID NO: 11) binds to an mRNA molecule that encodes a human VEGF protein and binds to an mRNA molecule that encodes a mouse VEGF protein, at least one isolated siRNA molecule (sense: 5′-CCAUCGAUGUCUACAUGAUCAUGGU-3′ (SEQ ID NO: 14), antisense: 5′-ACCAUGAUCAUGUAGACAUCGAUGG-3′) (SEQ ID NO: 15) binds to an mRNA molecule that encodes a human EGFR protein and binds to an mRNA molecule that encodes a mouse EGFR protein, and at least one isolated siRNA molecule (sense: 5′-GCUGAAGGUUGUGAAAUUCGGAGAA-3′ (SEQ ID NO: 18), antisense: 5′-UUCUCCGAAUUUCACAACCUUCAGC-3′) (SEQ ID NO: 19) binds to an mRNA molecule that encodes a human MGMT protein and binds to an mRNA molecule that encodes a mouse MGMT protein.