Patent ID: 8828438

Claim:
A composition consisting of a solid amorphous dispersion, said dispersion consisting of (1) a cholesteryl ester transfer protein (CETP) inhibitor, (2) an acid sensitive HMG-CoA reductase inhibitor, and (3) a concentration-enhancing polymer selected from the group consisting of neutral polymers, neutralized acidic polymers, and mixtures thereof; wherein at least 60 wt % of each of said CETP inhibitor and said HMG-CoA reductase inhibitor in said dispersion is amorphous, and said dispersion has a relative degree of improvement in chemical stability of said HMG-CoA reductase inhibitor of at least about 1.1 relative to a control composition consisting essentially of a solid amorphous dispersion of said CETP inhibitor, said HMG-CoA reductase inhibitor, and the acidic polymer hydroxypropyl methyl cellulose acetate succinate, wherein at least a major portion of both said CETP inhibitor and said HMG-CoA reductase inhibitor in said control composition is amorphous.