Patent ID: 7666855

Claim:
A compound of Formula II: wherein: B is selected from the group consisting of V is selected from the group consisting of optionally substituted monocyclic aryl and unsubstituted or substituted monocyclic heteroaryl wherein said substituted monocyclic aryl and said substituted monocyclic heteroaryl are substituted with 1-6 substituents selected from the group consisting of lower alkyl, lower alkoxy, lower perhaloalkyl, halogen, hydroxy, cyano, amino, —OR 3 , —OR 12 , —COR 3 , —CO 2 R 3 , —NR 3 2 , —NR 12 2 , —CO 2 NR 2 2 , —SR 3 , —SO 2 R 3 , and —SO 2 NR 2 2 ; W and W′ are independently selected from the group consisting of —H, methyl, and V, or W and W′ are each methyl, with the proviso that when W is V, then W′ is H; Z is selected from the group consisting of —H, —OMe, —OEt, phenyl, C 1 -C 3 alkyl, —NR 4 2 , —SR 4 , —(CH 2 ) p —OR 6 , —(CH 2 ) p —SR 6 and —OCOR 5 ; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group, containing 0-1 heteroatom, that is fused to an aryl group at the beta and gamma position to the O attached to the phosphorus; or together Z and W are connected via an additional 3-5 atoms to form a cyclic group, containing 0-1 heteroatom; or together W and W′ are connected via an additional 2-5 atoms to form a cyclic group; R 2 is selected from the group consisting of R 3 and hydrogen; R 3 is selected from the group consisting of alkyl, aryl, heterocycloalkyl, and aralkyl; R 4 is C 1 -C 4 alkyl; R 5 is selected from the group consisting of C 1 -C 4 alkyl, monocyclic aryl, and monocyclic aralkyl; and R 6 is C 1 -C 4 acyl; and together R 7 and R 8 form a cyclic carbonate; and R 10 is selected from the group consisting of OR 4 , OR 6 , NH 2 , NHR 4 , halogen, and H; or a pharmaceutically acceptable salt thereof.