Patent ID: 8476224

Claim:
A compound of Formula III: and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, atropisomers or racemates thereof, including pyridine N-oxides thereof; wherein q is 1, or 2 and the fragment is selected from the group consisting of: q is 0 and E-R 1 is selected from the group consisting of: R 1 is selected from the group consisting of hydrogen, hydroxymethyl, and aminomethyl and R 12 : R 2a is hydrogen, hydroxy or amino, or is selected from the group consisting of C 1-8 alkoxy, amino, mono- and di-C 1-8 alkylamino, C 3-7 cycloalkylC 0-6 alkoxy, each of which is substituted with hydroxy, oxo, halo, C 1-8 alkyl, haloC 1-8 alkyl, C 1-8 alkoxy, haloC 1-8 alkoxy, C 3-7 cycloalkylC 0-6 alkyl, COOH, NH 2 , mono- and di-C 1-8 alkylamino, tri-C 1-8 alkylammonium, heterocycleC 0-6 alkyl, heteroarylC 0-6 alkyl, or —(CH 2 —CH 2 —O—) n —R 8 ; R 3 is selected from R 12 , OR 12 , N(R 12 ) 2 or R 13 ; R 4 is selected from hydrogen, CO 2 R 4a , C(O)N(R 4a ) 2 , OR 3a , N(R 3a ) 2 , or C(R 10 )(R 11 )phenyl; R 4a is independently selected at each occurrence from hydrogen, hydroxymethyl, aminomethyl or R 12 ; R 6 is hydrogen or C 1-4 alkyl; R 7 is selected from the group consisting of H, OH, NH 2 , C 1-8 alkyl, C 1-8 alkoxy, and mono- and di-C 1-8 alkylamino; R 7b is independently selected at each occurrence from the group consisting of H, C 1-8 alkyl and —(CH 2 —CH 2 —O—) n —R 8 ; R 8 is independently selected at each occurrence from the group consisting of H, C 1-8 alkyl and CH 2 CO 2 H; R 10 is absent or hydrogen; R 11 is oxo, OR 4a , N(R 4a ) 2 , or ═NR 4a ; R 12 is independently selected at each occurrence from the group consisting of R 13 is independently selected from the group consisting of n is an integer of between 1-60,000 or is a mean of a plurality of integers having a value of between 1-60,000; and p is 0, 1, 2, 3, or 4.