Patent ID: 7858790

Claim:
A compound of formula Ia: or a phaimaceutically acceptable salt thereof, wherein R 1 is a C 1-12 aliphatic; or R 1 is a methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, or octyl, each of which is optionally substituted with 1-3 of halo or a cycloaliphatic, a heterocycloaliphatic, an alkylsulfanyl, an alkoxy, an amino, an acyl, or combinations thereof; or R 1 is a 3-8 membered monocyclic cycloaliphatic, a 7-10 membered bicyclic cycloalkyl or a 7-10 membered bicyclic cycloalkenyl; or R 1 is a 3-8 membered monocyclic heterocycloaliphatic having 1-3 heteroatoms selected from N, O, and S, which is optionally substituted with 1-3 of halo, aminocarbonyl, alkoxycarbonyl, acyl, carboxy or combinations thereof; or R 1 is a 7-10 membered bridged bicyclic heterocycloaliphatic, which is optionally substituted with 1-3 of halo, aminocarbonyl, alkoxycarbonyl, acyl, carboxy or combinations thereof; R 2 is a straight or branched (C 1-10 aliphatic(amino))carbonyl; or R 2 is a monocyclic cycloaliphaticaminocarbonyl; or R 2 is hydroxycarbonyl, a straight or branched (C 1-8 aliphatic(oxy))carbonyl group, or a (heterocycloaliphatic)carbonyl; Each R 3 is independently hydrogen, halo, or C 1-6 aliphatic; Z 1 is a bond; m is 0-4; n is 2; and p is 2.