Patent ID: 8329141

Claim:
A method for the locoregional treatment of abnormal tissue, comprising administering a composition comprising an unsealed and non-colloidal radiopharmaceutical to a subject in the region of the abnormal tissue, wherein the radiopharmaceutical is locally sequestered after introduction into the abnormal tissue, and has an effective amount of radioactivity for locoregional ablation of cells in the abnormal tissue, wherein the radiopharmaceutical is selected from the group consisting of Indium-111 chloride ( 111 In—Cl), Yttrium-90 chloride ( 90 YCl 3 ), Copper 61 chloride ( 61 Cu—Cl), Copper 62 chloride ( 62 Cu—Cl), Copper 64 chloride ( 64 Cu—Cl), Gallium 68 chloride ( 68 Ga—Cl), Gallium 67 chloride ( 67 Ga—Cl), Gallium 66 chloride ( 66 Ga—Cl), Gallium 68 citrate ( 68 Ga-citrate), Gallium 67 citrate ( 67 Ga-citrate), Gallium 66 citrate ( 66 Ga-citrate), Iodine-131 sodium iodide (Na 131 I), Holmium-166 DOTMP (166Ho-DOTMP), Samarium-153 EDTMP ( 153 Sm-EDTMP), F-18-2-deoxy-2-fluoro-D-glucose (F-18 FDG), iododeoxyuridine, meta-iodobenzylguanidine, iodocholesterol (NP59), and combinations thereof, wherein the abnormal tissue comprises a neoplasm, tumor, or synovial tissue, wherein the administering comprises intratumoral injection, intralesional injection, intramuscular injection, intracavitary injection, interstitial injection, or intrathecal injection, and wherein the administering comprises administering the composition directly to the abnormal tissue.