Patent ID: 7964601

Claim:
A compound having the formula of structure I: or an enantiomer, stereoisomer or diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein X is CH 2 ; R 1 is —L 1 -J; one of R 2a and R 2b is —L 2 —W and the remaining of R 2a and R 2b is hydrogen; R 3 is —L 3 -Q; L 1 is a linker unit selected from the group consisting of —(CH 2 ) 2 —, —(CH 2 ) 3 —, —(CH 2 ) y —C(═O)—, —C(═O)—CH 2 ) y — and —C(═O)—; J is a substituted or unsubstituted ring structure selected from the group consisting of wherein, when substituted, J is substituted with one or more ring substituents independently selected from the group consisting of hydroxyl, halogen, sulfonamide, alkyl or aryl groups attached directly or through an ether linkage; L 2 is —(CH 2 ) y —; W is —NH—C(═NH)—NH 2 ; L 3 is a linker unit selected from the group consisting of —(CH 2 ) y —CH(NR 6a R 6b )—(CH 2 ) y —, —(CH 2 ) y —C(═O)—CH(NR 6a R 6b )—(CH 2 ) y —, —(CH 2 ) y —C(═O)—, —(CH 2 ) y —CH(CH 3 )—C(═O)—, —C(═O)—CH 2 ) y —C(═O)—CH(NR 6a R 6b )—(CH 2 ) y —, —C(═O)—(CH 2 ) y —, —C(═O)—CH 2 ) y —CH(NR 6a R 6b )—, —C(═O)—(CH 2 ) y —CH(NR 6a R 6b )—(CH 2 ) y —, —C(═O)—(CH 2 ) y —CH(NHR 6a R 6b )—C(═O)— and —C(═O)—; Q is naphthyl; R 6a and R 6b are each independently selected from the group consisting of hydrogen and R 7 ; R 7 is an amino acid residue or an amine capping group, wherein the amino acid residue is an L-amino acid and the amine capping group is selected from the group consisting of methyl, ethyl, isopropyl and acetyl; one or two of R 4a , R 4b , R 5a , and R 5b are independently a C 1 to C 6 aliphatic linear or branched chain and the remaining of R 4a , R 4b , R 5a , and R 5b are hydrogen, provided that at least one of R 4a and R 4b and at least one of R 5a and R 5b are hydrogen; and y is from 1 to 6, provided that where any linker unit includes two y index values, the total of such y index values is from 2 to 6.