Patent ID: 7074560

Claim:
An isolated nucleic acid encoding an affinity ligand, said ligand comprising: Arg-X 1 -Cys-X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -Cys-X 8 (SEQ ID NO:43), wherein X 1 is Trp or Leu; X 2 is Pro, Ser, Thr or Ile; X 3 is Arg, Lys or Thr; X 4 is Ser, Tyr, Thr or Ala; X 5 is Ser, Tyr, Asp, Val, Pro, Ala, His, Asn or Thr; X 6 is Leu, Met, Gln, Arg or Lys; X 7 is Glu, Gly or Arg; and X 8 is Lys, Met, Ala, Val, Leu, Ile, Phe, Pro or Trp; and wherein said affinity ligand binds tPA.