Patent ID: 8343542

Claim:
A method for producing a pharmaceutical composition that when placed in the mouth immediately disintegrates releasing active ingredient (a) comprising: vigorously mixing (a) an anionic active pharmaceutical ingredient with (b) a copolymer consisting of free-radical polymerized C 1 to C 4 esters of acrylic or methacrylic acid and further (meth)acrylate monomers which have functional tertiary amino groups, (c) 5 to 50% by weight, based on (b), of a C 12 to C 22 carboxylic acid, and (d) 0.1 to 10% by weight, based on the weight of the powder, of a release agent selected from the group consisting of talc, Mg stearate or Ca stearate, ground silica, kaolin or nonionic emulsifiers having an HLB of between 3 and 8 in a melt, solidifying the mixture, and grinding to an active ingredient-containing powder with an average particle size of 200 μm or less, incorporating the powder into a water-soluble matrix of at least one pharmaceutically acceptable excipient, with the proviso that not more than 3% by weight, based on the copolymer (b) of emulsifiers having an HLB of at least 14 may be present.