Patent ID: 8546579

Claim:
A bicycloheteroaryl compound having a formula: wherein B and Y are independently selected from CR 2a ; W, W′ and Z are each independently CR 4 ; L 1 is substituted or unsubstituted C 1 C 5 alkylene; n is 1, 2, 3 or 4; R 1 is selected from a substituted or unsubstituted heterocycloalkyl, aryl and heteroaryl ring; each of R 2a , R 2′ and R 2″ is independently selected from hydrogen, halo, and substituted or unsubstituted C 1 -C 6 alkyl; or any of R 2′ and R 2″ join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms; R 3 is hydrogen or a functional group selected from acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted dialkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, nitro, and thio; provided that R 3 is other than hydrogen bond donor group; R 4 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted dihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio; and the dotted bond is a double bond; or a pharmaceutically acceptable salt thereof; and stereoisomers, isotopic variants and tautomers thereof.