Patent ID: 8148508

Claim:
An isolated nucleic acid encoding a polypeptide for production of a GLP-2 peptide, the encoded polypeptide comprising: two or more copies of the GLP-2 peptide; and a clostripain cleavage recognition sequence; wherein the clostripain cleavage recognition sequence is comprised of amino acids at the N-terminus and/or the C-terminus of the GLP-2 peptide and/or of an optional linker, the clostripain cleavage recognition sequence positioned to allow cleavage by clostripain between the copies of the GLP-2 peptide; wherein the clostripain cleavage recognition sequence comprises Formula I: -Xaa 1 -Xaa 2 -Xaa 3 - (I); wherein Xaa 1 is aspartic acid, glycine, proline or glutamic acid, Xaa 2 is arginine, and Xaa 3 is not an acidic amino acid.