Patent ID: 8765931

Claim:
A double-stranded oligonucleotide having the structure: 5′ iB-GCCAGAAUGUGGAACUCCU 3′ (sense strand; SEQ ID NO: 9015) 3′ CGGUCUUACACCUUGAGGA 5′ (antisense strand; SEQ ID NO: 9516) wherein each of A, C, U, and G is a nucleotide and each consecutive nucleotide is joined to the next nucleotide by a phosphodiester bond; wherein the sense strand comprises, counting from the 5′ terminus, an unmodified ribonucleotide at each of positions 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 and 19, a L-deoxycytidine at position 18, and an inverted deoxyabasic moiety (iB) covalently attached at the 5′terminus; and wherein the antisense strand comprises, counting from the 5′ terminus, a 2′-O-Methyl sugar-modified ribonucleotide at each of positions 2, 4, 6, 8, 11, 13, 15, 17 and 19 and an unmodified ribonucleotide at each of positions 1, 3, 5, 7, 9, 10, 12, 14, 16 and 18; or a pharmaceutically acceptable salt of the double-stranded oligonucleotide.