Patent ID: 8778921

Claim:
A solid composition, comprising a sulfite; and a compound of formula (I): wherein: R 1 is —H, —OR 8 , —SR 8 —N(R 8 )(R 9 ), —N(R 8 )C(O)R 9 , —N(R 8 )C(O)OR 9 , —N(R 8 )C(O)N(R 8 )(R 9 ), —OC(O)R 8 , —OC(O)OR 8 , —OS(O) 2 R 8 , —OS(O) 2 OR 8 , —OP(O) 2 OR 8 or —CN; each of R 2 and R 3 is, independently, selected from —H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, aralkyl, heteroaryl, heteroaralkyl, or —C(═O)CH 3 ; or R 2 and R 3 taken together with the nitrogen to which they are bonded represent a 3- to 8-membered heterocyclyl ring which contains 1 to 3 heteroatoms selected from O, N, S, and P; R 4 is —H, alkyl, alkenyl or aralkyl; R 5 and R 6 are each —H, or R 5 and R 6 taken together form a bond; R 7 is —H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; and each instance of R 8 and R 9 is, independently, selected from —H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or R 8 and R 9 taken together represent a 3 to 8 membered optionally substituted heterocyclyl ring which contains 1 to 3 heteroatoms selected from O, N, S, and P; the sulfur content of the composition is greater than 0.5 percent as measured by Elemental Analysis; at least about 80% of the original amount of the compound of formula (I) remains after said composition is stored for 14 days at 40° C. and 75% relative humidity; and the sulfite is selected from the group consisting of potassium bisulfite, sodium bisulfite, calcium bisulfite, magnesium bisulfite, potassium metabisulfite, sodium metabisulfite, calcium metabisulfite, magnesium metabisulfite, potassium sulfite, sodium sulfite, calcium sulfite, magnesium sulfite, potassium hydrosulfite, sodium hydrosulfite, calcium hydrosulfite, magnesium hydrosulfite, and sodium formaldehyde sulfoxylate.