Patent ID: 7446118

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: p is 1 or 2; Y is CR c ; Ar is: (a) indolyl selected from indol-4-yl, indol-5-yl, indol-6-yl, and indol-7-yl, each optionally substituted; R 1 is: (a) aryl selected from phenyl and naphthyl, each optionally substituted; or (b) heteroaryl selected from indolyl, indazolyl, pyridinyl, thienyl, furanyl, pyrimidinyl, pyridazinyl, pyrazinyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, imidazolyl, pyrazolyl, quinolinyl, isoquinolinyl, quinoxalinyl, benzothiazolyl, benzofuranyl, benzothiophenyl or benzoxazinyl, each optionally substituted; (c) optionally substituted arylalkyl; (d) optionally substituted heteroarylalkyl; (e) cycloalkyl; or (f) cycloalkylmethyl; R 2 and R 3 each independently is: (a) hydrogen; (b) alkyl; (c) hydroxyalkyl; (d) alkoxyalkyl; (e) benzyl; or (f) R 2 and R 3 together with the nitrogen to which they are attached may form an optionally substituted four to seven membered ring that optionally includes an additional heteroatom selected from N, O and S; R a is: hydrogen; fluoro; or alkyl; R b is: hydrogen; alkyl; hydroxy; alkoxy; fluoro; or hydroxyalkyl; or one of R 2 and R 3 together with one of R a and R b and the atoms to which they are attached may form a five or six membered ring that optionally includes an additional heteroatom selected from O, N and S; R c and R d each independently is: hydrogen; or alkyl; or R c and R d together form ═O, ═S, or ═NR f , wherein R f is hydrogen, alkyl, or —OR g , wherein R g is hydrogen or alkyl; or one of R 2 and R 3 together with one of R c and R d together with the atoms to which they are attached may form a four to six membered ring that optionally includes an additional heteroatom selected from O, N and S; and R e is hydrogen or alkyl.