Patent ID: 7326788

Claim:
A compound of Formula (I): or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein R 1 is —H; R 2 is a 5- to 7-membered mono- or a 8- to 10-membered bicyclic heteroaromatic or heterocyclic ring having from one to four heteroatoms selected from N, O or S, and may be optionally substituted with one or more of —C 1-6 alkyl, amino, aminoalkyl, heteroaryl, halogen, hydroxy, —CF 3 , alkoxy, aryl, aralkyl, heteroaralkyl, aryloxy, arylalkoxy, —OCF 3 , —OCO-alkyl, —COR a , —CN, —COOR a , —CONR a R b , —N(R a )COR b , —NO 2 , —SO 2 R a , —SO 3 R a , —SO 2 NR a R b , —N═C(R a )—NR b R c , —CH 2 NR a R b , —CH 2 NR a R b NR c R d , —NR a SO 2 R b ,—NR a CONR b R c , —N(R a )CON(R b )-alkyl-R c , or —CH 2 N(CH 2 CH 2 ) 2 NR a ; R 3 is phenyl, naphthyl or cycloalkyl, each of which may be optionally substituted with one or more of —C 1-6 alkyl, —C 2-6 alkenyl, amino, aminoalkyl, heteroaryl, halogen, hydroxy, —CF 3 , alkoxy, aryl, aralkyl, heteroaralkyl, aryloxy, arylalkoxy, —OCF 3 , —OCO-alkyl, —COR a , —CN, —COOR a , —CONR a R b , —N(R a )COR b , —NO 2 , —SR a , —SO 2 R a , —SO 3 R a or —SO 2 NR a R b ; or a 5- to 7-membered mono- or a 8- to 10-membered bicyclic heteroaromatic ring having from one to four heteroatoms selected from N, O or S, and may be optionally substituted with one or more of —C 1-6 alkyl, —C 2-6 alkenyl, amino, aminoalkyl, heteroaryl, halogen, hydroxy, —CF 3 , alkoxy, aryl, aralkyl, heteroaralkyl, aryloxy, arylalkoxy, —OCF 3 , —OCO-alkyl, —COR a , —CN, —COOR a , —CONR a R b , —N(R a )COR b , —NO 2 , —SR a , —SO 2 R a , —SO 3 R a or —SO 2 NR a R b ; X is O; and Y 1 , Y 2 , Y 3 and Y 4 are —C(R 4 )—, wherein each R 4 is independently —H, —C 1-6 alkyl, —C 2-6 alkenyl, amino, aminoalkyl, halogen, hydroxy, hydroxyalkyl, —CF 3 , alkoxy, aryl, aralkyl, heteroaryl, heteroaralkyl, aryloxy, heteroaryloxy, arylalkoxy, SR a , NR a R b , PhCF 3 , —OCF 3 , —OCO-alkyl, —COR a , —CN, —COOR a , —CONR a R b , —N(R a )COR b , —NO 2 , —SO 2 R a , —SO 3 R a or —SO 2 NR a R b , —N(R a )SO 2 R b , or wherein R a , R b , R c and R d are independently hydrogen, alkoxy, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, heteroaralkyl or heteroaryl, any one of which except hydrogen may be substituted with one or more of the following: —SO 2 NH 2 , SO 2 -alkyl, or —CO 2 -alkyl.