Patent ID: 8119800

Claim:
A method of preparing a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 3 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclyl, substituted carbocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, or substituted heterocyclyl, arylalkyl, substituted arylalkyl, heteroarylalkyl; or substituted heteroarylalkyl; X 1 is alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, carbocyclylene, substituted carbocyclylene, heterocyclylene, or substituted heterocyclylene; X 2 is a covalent bond, alkylene, or substituted alkylene; Y is selected from a group consisting of: L 1 and L 2 are each independently a covalent bond, —O—, or —NR 6 —; R 4 and R 5 are each independently H, alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, -alkylene-C(O)—O—R 7 , -(substituted alkylene)-C(O)—O—R 7 , -alkylene-O—C(O)—O—R 7 , or -(substituted alkylene)-O—C(O)—O—R 7 ; and R 6 and R 7 are each independently H, alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, heterocyclylalkyl, or substituted heterocyclylalkyl; comprising: (d) reacting a compound of Formula (II) wherein G is Cl, Br or I with a cyanide reagent: thereby forming a compound of Formula (III): (e) reacting the compound of Formula (III) with R 1 Z 1 , wherein Z 1 is a leaving group, thereby forming a compound of Formula (IV): (f) reacting the compound of Formula (IV) with Y—X 2 —O—X 1 —Z 2 , wherein Z 2 is a leaving group, thereby forming the compound of Formula (I).