Patent ID: 7960436

Claim:
A compound of formula I where Ar 1 is a 5- to 10- member mono- or bicyclic aromatic group, optionally containing 1 -4 heteroatoms selected independently from N, O, and S; R 1 and R 2 are selected, independently, from H, CN, halogen, CH 2 CN, OH, NO 2 , CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , C 1 -C 6 alkyl, OR 8 , C(═O)R 9 , C(═O)OR 10 , OC(═O)R 11 , SR 12 , NR 13 C(═O)R 14 , C(═O)NR 15 R 16 , CH 2 C(═O)NR 15 R 16 , NR 17 R 18 , SO 2 R 19 , N(R 20 )SO 2 R 21 , SO 2 NR 22 R 23 , C 3 -C 6 cycloalkyl, C 5 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; where the —NR 3 R 4 group is situated ortho to the NHC(═X) group and R 3 and R 4 are, independently, H or C 1-6 alkyl, which C 1-6 alkyl group optionally substituted with 1 or 2 groups selected, independently, from methyl, halogen, methoxy, and hydroxy, or R 3 and R 4 together form a 5- or 6- membered ring, optionally substituted with halogen, methyl, methoxy, or hydroxy and optionally containing one or two double bonds; n=1 or 2; X═O or S; Y is O or S; q=1 or 0; R 5 is C 1 -C 6 alkyl, (CHR 6 ) w C 3 -C 6 cycloalkyl, (CHR 6 ) w CH 2 C 3 -C 6 cycloalkyl, CH 2 (CHR 6 ) w C 3 -C 6 cycloalkyl, (CHR 6 ) w C 5 -C 6 cycloalkenyl, CH 2 (CHR 6 ) w C 5 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Ar 2 , (CHR 6 ) w Ar 2 , CH 2 (CHR 6 ) w Ar 2 , or (CHR 6 ) w CH 2 Ar 2 , where w=0−3, Ar 2 is a 5- to 10-member mono- or bicyclic aromatic group, optionally containing 1−4 ring heteroatoms selected independently from N, O, and S; R 6 is C 1 -C 3 alkyl; and R 8 -R 23 are, independently, H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, (CHR 6 ) w C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, , C 2 -C 6 alkynyl, where all said alkyl, cycloalkyl, alkenyl, alkynyl, aryl, groups are optionally substituted with one or two substituents selected independently from C 1 -C 3 alkyl, halogen, OH, OMe, CN, CH 2 F, and trifluoromethyl; where, additionally, said alkenyl and alkynyl groups are optionally substituted with phenyl or C 3 -C 6 cycloalkyl; and where all said cycloalkyl groups optionally contain one or two ring heteroatoms selected independently from N, O, and S.