Patent ID: 8691882

Claim:
An organic-inorganic hybrid scaffold comprising: a chitosan comprising primary amine terminals; and a nano-hydroxyapatite particle immobilized to the chitosan via a polymeric link linking between the chitosan and the nano-hyproxyapatite particle, wherein the nano-hydroxyapatite particle comprises a polymeric moiety grafted onto a surface thereof, wherein the grafted polymeric moiety comprises at least one of a phosphonic acid terminal and a carboxylic acid terminal, and wherein the polymeric link comprises a peptide or phosphoramidate bond formed by a reaction in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) between one of the primary amine terminals of the chitosan and the carboxylic acid terminal or the phosphonic acid terminal of the grafted polymeric moiety.