Patent ID: 7108846

Claim:
A method for the synthesis of a [ 18 F]-labeled perfluorinated-nitroaromatic compound having the formula: wherein R 1 is CH 2 and R 2 is an alkyl group having up to about 6 halogen atoms, wherein said alkyl group has the formula CHXCX 2 CY 3 where X is halogen or hydrogen and Y is fluorine, comprising (1) perfluroinating a first intermediate which is an amino acid derivative which is N-protected by an imido group or a synthetically equivalent group having a carboxyl function transformed into a dithioester function or a synthetically equivalent persulphurated moiety thereby obtaining a [ 18 F]-labeled perfluorinated amino acid derivative which is N-protected by an imido group or a synthetically equivalent group as a second intermediate and (2) deprotecting the nitrogen function of said second intermediate, resulting in a [ 18 F] labeled perfluoroalkyl amine derivative, and coupling 2-(2-nitro-imidazol-1-yl) acetic acid with a [ 18 F] labeled perfluoroalkyl amine derivative.