Patent ID: 7173027

Claim:
A compound of the formula below, or the physiologically acceptable salts, diasteromers, enantiomers, double bond isomers, or mixtures thereof: wherein: Z is hydrogen; R is hydrogen; R 1 is selected from NH, O, S or CH 2 ; R 2 is selected from CH 3 , CF 3 , CH 2 Câ‰¡CH, CH 2 CH 2 â•CH 2 or CH 2 Ph; and Ar is selected from; phenyl with no more than two substituents each independently selected from amino, halogen, hydroxy, nitro, nitroso, azido, isothiocyanato, cyano; COOH, CONR 3 R 4 where R 3 and R 4 are each independently selected from H, alkyl or substituted alkyl, NCOR 3 R 4 where R b 3 and R 4 are each independently selected from H, alkyl, substituted alkyl or CF 3 and NSO 2 R 3 R 4 where R 3 and R 4 are each independently selected from H, alkyl, substituted alkyl or CF 3 ; naphthyl with no more than two substituents each independently selected from amino, halogen, hydroxy, nitro, nitroso, azido, isothiocyanato, cyano or COOH, CONR 3 R 4 where R 3 and R 4 are each independently selected from H, alkyl or substituted alkyl, NCOR 3 R 4 where R 3 and R 4 are each independently selected from H, alkyl, substituted alkyl or CF 3 , NSO 2 R 3 R 4 where R 3 and R 4 are each independently selected from H, alkyl, substituted alkyl or CF 3 ; or a salt of any of the above, with the provisos that: if R 2 is CH 3 or CH 2 Ph; then Ar cannot be unsubstituted phenyl; phenyl substituted by from one to two substituents selected from the group consisting of fluorine, chlorine, bromine, hydroxy, nitro and amino; 1- or 2-naphthyl or 1- or 2-naphthyl substituted by from one to two substituents selected from the group consisting of fluorine, chlorine and bromine; and if R 1 is CH 2 and R 2 is CH 3 ; then Ar cannot be phenyl substituted by from one to two halogen atoms; 1- or 2-naphthyl or 1- or 2-naphthyl substituted by from one to two substituents selected from the group consisting of halogen, hydroxy, and cyano; anthracenyl or anthracenvl substituted by from one to two substituents selected from the group consisting of fluorine, chlorine, bromine hydroxy, and cyano.