Patent ID: 7317008

Claim:
A method of treating ischemic reperfusion injury in a subject comprising administering to subject in need of treatment for ischemic reperfusion injury an effective amount of a pharmaceutically acceptable formulation comprising a synthetic analog or derivative of a carotenoid; wherein the synthetic analog or derivative of the carotenoid has the structure where each R 3 is independently hydrogen or methyl; where each Y is independently O or H 2 ; where each R is independently OR 1 or R 4 ; where each R 1 is independently -alkyl-NR 2 3 + , -aryl-NR 2 3 + , -alkyl-CO 2 − , -aryl-CO 2 − , -amino acid-NH 3 + , -phosphorylated amino acid-NH 3 + , polyethylene glycol, dextran, H, alkyl, or aryl; where each R 4 is independently -alkyl-NR 2 3 + , alkyl-NR 2 2 , -aryl-NR 2 3 + ,-alkyl-CO 2 − , alkyl-CO 2 H; -alkyl-CO 2 R 6 , aryl-CO 2 − , -amino acid-NH 2 , amino acid-NH 3 + , -phosphorylated amino acid-NH 3 + , polyethylene glycol, dextran, H, alkyl, aryl, -alkyl-O—PO 2 —O-alkyl-NR 2 3 + , where P′ is-alkyl-O, alkyl, or aryl; where each R 2 is independently H, alkyl, or aryl; where each R 5 is independently H, alkyl, benzyl, or alkali salt; where n is between 0 to 12; where R 6 is alkyl, —CH 2 —CH(OH)—CH 2 —O—PO 2 —O-alkyl-NR 2 3 + , and where R 7 is -alkyl-NR 2 3 + , -aryl-NR 2 3 + , -alkyl-CO 2 − , -aryl-CO 2 − , -amino acid-NH 3 + , -phosphorylated amino acid-NH 3 + , polyethylene glycol, dextran, H, alkyl, or aryl.