Patent ID: 7785787

Claim:
A method of isolating nucleic acids from a nucleic acid-containing sample, the method comprising: reacting an anion exchanger with a silanized solid support to form a silane-anion exchanger complex; contacting a nucleic acid-containing sample to the silane-anion exchanger complex formed on the silanized solid support to capture nucleic acids to form a silane-anion exchanger-nucleic acid complex; and treating the silanized solid support with an alkaline solution of pH 9 to 14 such that the silane layer is removed from the solid support resulting in removal of the silane-anion exchanger-nucleic acid complex, wherein the content of silane is in the range from 0.0001 to less than 1% by volume based on the total of the resultant solution after the alkaline solution treatment.