Patent ID: 8889171

Claim:
A tissue regeneration substrate, comprising: a bioabsorbable porous substrate that contains collagen and alkali-treated gelatin, the bioabsorbable porous substrate being chemically cross-linked and having a basic fibroblast growth factor (bFGF) therein, wherein the content of the alkali-treated gelatin in the bioabsorbable porous substrate is about 10 wt. %, wherein the tissue regeneration substrate has small pores with an average pore diameter of about 10 μm to about 500 μm, wherein the amount of the bFGF released to phosphate buffer saline (PBS) after being dipped in the PBS at 37° C. for three days is not greater than 7 wt. % of the total amount of the bFGF initially contained in the tissue regeneration substrate, and wherein the amount of the bFGF released to phosphate buffer saline (PBS) after being dipped in the PBS at 37° C. for seven days is not greater than 15 wt. % of the total amount of the bFGF initially contained in the tissue regeneration substrate.