Patent ID: 7741299

Claim:
A compound having the structure: wherein each of A, C, G and U represents a ribonucleotide; wherein in alternating ribonucleotides in each of the antisense and the sense strands, a 2′-O-methyl group is present in the sugar residue; wherein the ribonucleotide at each of the 5′ terminus and the 3′ terminus of the antisense strand comprises a 2′-O-methyl group in the sugar residue; wherein the ribonucleotide at each of the 5′ terminus and the 3′ terminus of the sense strand is unmodified in the sugar residue; wherein each ribonucleotide at the 5′ terminus and the 3′ terminus of the antisense strand and of the sense strand is independently phosphorylated or non-phosphorylated; and wherein each vertical line (|) represents base pairing.