Patent ID: 8367697

Claim:
A compound represented by structural formula IA: or a pharmaceutically acceptable salt thereof wherein: A and A′ are independently —N— or —C(R + )—; ring B is five- or six-membered saturated carbocyclic or heterocyclic ring; R 1 is halogen, —CN, —NO 2 , or -T1-Q1; T1 is absent or a C1-10 aliphatic wherein one or more methylene units of T1 are optionally and independently replaced by G wherein G is —O—, —S(O) p —, —N(R′)—, or —C(O)—; and T1 is optionally and independently substituted with one or more J T1 ; Q1 is absent or a 3-8 membered saturated, partially saturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from the groups consisting of O, N, and S, or an 8-12 membered saturated, partially saturated, or fully unsaturated bicyclic ring having 0-5 heteroatoms independently selected from the group consisting of O, N, and S, wherein Q1 is optionally and independently substituted with one or more J Q1 ; wherein when R 1 is T1-Q1, then T1 and Q1 are not both absent; each R 5 and R 6 are independently —H, halogen, C1-10 haloaliphatic, or C1-10 aliphatic; each R 7 is independently C1-10 haloaliphatic, C1-10 aliphatic, halogen, —NO 2 , —(CR ++ 2 ) n CN, —(CR ++ 2 ) n N(R**) 2 , —(CR ++ 2 ) n OR**, or —(CR ++ 2 ) n C(O)N(R**) 2 , or two R 7 groups together with the carbon to which they are attached form C═O; each J T1 is independently halogen, —OR^, —N(R^) 2 , or —CN; each J Q1 is independently halogen, C1-10 alkyl, C1-10 haloalkyl, —OR″, —N(R″) 2 , —CN, —NO 2 , —S(O) p R″, —S(O) p NR″, acyl, carbalkoxyalkyl, or acetoxyalkyl; each R + is independently —H, halogen, or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each R ++ is independently —H or halogen; each R′ is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each R^ is independently —H, C1-10 alkyl, or aralkyl wherein each R^ is optionally and independently substituted with up to five halogen groups; each R″ is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each R** is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; x is 0 or 1; y is 0, 1 or 2; each n is independently 0, 1, 2, or 3; and each p is independently 0, 1, or 2.