Patent ID: 7353152

Claim:
A method for creating a computer model of diabetes, comprising: identifying data relating to diabetes, the data relating changes in biological states to biological attributes of diabetes; identifying a plurality of biological processes related to the data, the plurality of biological processes defining at least one portion of the disease state of diabetes; and combining the plurality of biological processes to form a simulation of glucose metabolism, wherein the simulation comprises a representation of two macronutrient metabolisms selected from the group consisting of fat metabolism, protein metabolism and carbohydrate metabolism, wherein a representation of fat metabolism comprises a representation of at least one biological process selected from the group consisting of regulation of adipose tissue uptake of free fatty acid, regulation of adipose tissue lipolysis, regulation of adipose tissue triglyceride esterification, hepatic lipoprotein regulation, muscle free fatty acid uptake, and muscle free fatty acid utilization; and a representation of protein metabolism comprises a representation of at least one biological process selected from the group consisting of production of amino acids from carbohydrate in muscle, hepatic gluconeogenesis from amino acid substrate, oxidation of amino acids in muscle, oxidation of amino acids in liver, and regulation of skeletal muscle protein turnover in response to a stimulus selected from activity, exercise, fat mass, dietary composition, and insulin; producing a simulated biological attribute associated with at least one biological attribute of diabetes based on the combined plurality of biological processes; and storing the simulated biological attribute in a computer-readable medium.