Patent ID: 8598356

Claim:
A chemical entity selected from compounds of Formula (I): wherein: Ar 1 is pyridyl, independently unsubstituted or substituted with halo, —C 1-4 alkyl, —OC 1-4 alkyl, —OCF 3 , —CN, or —CF 3 ; Ar 2 is (i) phenyl unsubstituted or substituted with one or two R a moieties; where each R a moiety is independently —C 1-8 alkyl, —OC 1-8 alkyl, halo, —CF 3 , —OCF 3 , —OCH 2 CF 3 , —S(O) 0-2 C 1-8 alkyl, —S(O) 0-2 CF 3 , —CO 2 H, —N(R b )R c , —SO 2 NR b R c , —NR b SO 2 R c , —C(O)NR b R c , or —NO 2 ; or two adjacent R a moieties taken together form —O(CH 2 ) 1-2 O— or —OCF 2 O—; where R b and R c are each independently —H or —C 1-8 alkyl, or optionally R b and R c taken together with the atoms of attachment form a 4-8 membered ring; or (ii) phenyl substituted at the 3- or 4-position with -L-Ar 3 , unsubstituted or substituted with one or two R a moieties, wherein: L is a linker selected from the group consisting of —(CH 2 ) 1-6 —, —CH═CH—, —O—, —C 1-6 alkyl-O—C 1-6 alkyl-, —C 1-6 alkyl-N(C 1-6 alkyl)-C 1-6 alkyl-, —C 1-6 alkyl-S(O) 0-2 C 1-6 alkyl-, —C≡C—, —C(O)—, or a covalent bond; Ar 3 is: (a) phenyl unsubstituted or substituted with one or two R a moieties; (b) a monocyclic heteroaryl group unsubstituted or substituted with one or two R a moieties; or (c) a 9- or 10-membered fused bicyclic heteroaryl group unsubstituted or substituted with one or two R a moieties; and pharmaceutically acceptable salts of compounds of Formula (I).