Patent ID: 8513205

Claim:
A compound according to the chemical structure: Where A is a nucleoside reverse transcriptase inhibitor (NRTI) compound or a nucleoside competitive reverse transcriptase inhibitor (NCRIT) compound modified to form a chemical bond with said linker group without significant loss of HIV-1 reverse transcriptase inhibitory activity, B is a non-nucleoside reverse transcriptase inhibitor compound modified to bond to said linker group without significant loss of HIV-1 reverse transcriptase inhibitory activity and said linker is a linker group according to the chemical structure: Where Z and Z′ are each independently a bond, —(CH 2 ) i —O, —(CH 2 ) i —S, —(CH 2 ) i —N—R, wherein said —(CH 2 ) i group, if present in Z or Z′, is bonded to A or B; each R is independently H, or a C 1 -C 3 alkyl or alkanol group; Each R 2 is independently H or a C 1 -C 3 alkyl group; Each Y is independently a bond, O, S or N—R; Each i is independently 0, 1, 2 or 3; D is or a bond, with the proviso that Z, Z′ and D are not each simultaneously bonds; j is 1, 2, 3 or 4, m is 1, 2, 3, 4, 5 or 6; n is 1, 2 or 3; and X′ is O, S or N—R or a pharmaceutically acceptable salt thereof.