Patent ID: 6987092

Claim:
Cell membrane penetrating indirubin derivative having the general formula (I): wherein Y is O, and X represents a group N—A—B—R 14 in which A represents an oxygen atom, B represents a group [(CD 2 ) n Z] m wherein D represents a hydrogen atom, a straight chain or branched-chain alkyl group having 1 to 18 carbon atoms which can additionally carry one or more hydroxy and/or amino groups, Z is an oxygen atom or —NH—, n is an integer and m is an integer, wherein n and m are not 0, the group R 14 represents a hydrogen atom, a straight-chain or branched-chain alkyl group having 1 to 18 carbon atoms which can carry one or more hydroxy groups and/or amino groups, a substituted or unsubstituted aryl group, which can comprise one or more heteroatoms, an aralkyl group or a glycoside selected from monosaccharides, disaccharides or oligosaccharides, or a derivative of the glycoside, R 2 , R 3 , R 4 , R 5 , R 7 , R 8 , R 9 and R 10 can be the same or different and represent a hydrogen atom; a halogen atom; a hydroxy group; a nitroso group; a nitro group; an aryloxy group; an alkoxy group; a straight-chain or branched-chain alkyl group having 1 to 18 carbon atoms which can additionally carry one or more hydroxy and/or amino groups; a cycloalkyl group having 3 to 7 carbon atoms which can comprise one or more heteroatoms; a substituted or unsubstituted aryl group which can comprise one or more heteroatoms; an aralkyl group; a trifluoromethyl group; a —COOM group; a —CH 2 COOM group, wherein M is hydrogen, a straight-chain or branched-chain alkyl group having 1 to 18 carbon atoms which can additionally carry one or more hydroxy and/or amino groups; a NR 11 R 12 group, or a SO 2 NR 11 R 12 group, wherein R 11 and R 12 can be the same or different and represent a hydrogen atom, a straight-chain or branched-chain alkyl group having 1 to 18 carbon atoms which can additionally carry one or more hydroxy and/or amino groups, and R 1 and R 6 each represents a hydrogen atom.