Patent ID: 8686146

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: each of R A , R B , R C and R D is independently hydrogen, hydroxy, acyloxy, halo, cyano, nitro, optionally substituted (1-6C) alkyl or optionally substituted (1-6C) alkoxy; or two adjacent R A , R B , R C and R D radicals form a methylenedioxy or ethylenedioxy group and each of the others is defined as above; R E is â€”(CH 2 ) n R N ; n is 2, 3 or 4; R N is 1-imidazolyl or 1,2,4-triazol-2-yl; or R N is â€”NR 1 R 2 ; in which each of R 1 and R 2 is independently hydrogen or (1-3C) alkyl or in which one of R 1 and R 2 is hydrogen and the other of R 1 and R 2 is 2-hydroxyethyl; or â€”NR 1 R 2 forms a pyrrolidino, piperidino, piperazino, morpholino or thiomorpholino group, each of which may bear one or more methyl substituents; in which a pyrrolidino or piperidino may bear a hydroxy substituent on a carbon not bound to nitrogen; and in which a pyrrolidino or piperidino may be a 3,4-didehydro moiety; W is N or CR W ; X is N or CR X ; Y is N or CR Y ; Z is N or CR Z ; one of W, X, Y and Z is N, and each of the others of W, X, Y and Z is CR W , CR X , CR Y or CR Z , respectively; and each of R W , R X , R Y and R Z , is independently hydrogen, (1-3C) alkyl, (1-3C) alkoxy, or acyloxy.