Patent ID: 7803622

Claim:
A composition comprising: a) a first adeno-associated virus vector comprising linked: i) a first DNA segment comprising a 5′-inverted terminal repeat of adeno-associated virus; ii) a second DNA segment comprising a promoter operably linked to a DNA fragment comprising an exon of a gene and a splice donor site, wherein the second DNA segment does not encode a full-length polypeptide; and iii) a third DNA segment comprising a 3′-inverted terminal repeat of adeno-associated virus; and b) a second adeno-associated virus vector comprising linked: i) a first DNA segment comprising a 5′-inverted terminal repeat of adeno-associated virus; ii) a second DNA segment comprising a splice acceptor site and a DNA fragment with at least one other exon which together with the DNA segment of (a)(ii) encodes a full-length polypeptide; and iii) a third DNA segment comprising a 3′-inverted terminal repeat of adeno-associated virus.