Patent ID: 8048437

Claim:
A medical device comprising: a structure adapted for introduction into a patient or contact with blood or tissue of a patient, wherein the structure comprises a metal surface; a silane-modified surface comprising layer of hydrolyzed and cured silane reagent on the metal surface of the medical device, wherein the silane reagent comprises octadecyltrimethoxysilane (ODtMOS), and wherein the silane-modified surface is deactivating to the complement cascade as compared to the non-coated surface of the medical device; a layer of coating applied on the silane-modified surface of the medical device, wherein the coating on the silane-modified surface of the medical device comprises a block copolymer and a regulator of complement activation coupled to the block copolymer, wherein the regulator of complement activation is selected from the group consisting of factor H, factor H like protein 1 (FHL-1), factor H related proteins, C4 binding protein (C4bp), complement receptor 1 (CR1), compstatin, decay-accelerating factor (DAF), membrane cofactor protein (MCP), vaccinia virus complement control protein (VCP), small pox inhibitor of complement enzymes (SPICE), and fragments thereof such that the surface of the medical device is deactivating to the complement cascade as compared to the non-coated surface of the medical device.