Patent ID: 7408075

Claim:
A method, comprising the steps of: contacting with a calcium salt of phosphocholine to form and reacting said with to form wherein X is bromo, chloro, iodo, tosyl, or mesyl; R 1 is H or alkyl; Y is —(CH 2 ) n — optionally substituted at any one or more methylene unit with halo, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, heterocyclyl, heterocycloalkyl, aryl, aralkyl, aryloxy, heteroaryl, heteroaralkyl, perfluoroalkyl, alkylamido, acyl, acyloxy, alkanesulfonamido, alkoxy, perfluoroalkoxy, alkylamino, carboxamido, carboalkoxy, or carboxyalkyl, or optionally one or more methylene unit is replaced with O, S, or NH, or a combination thereof; n is an integer from 0 to 20; and Z is an electron withdrawing group.