Patent ID: 7135467

Claim:
A compound having the formula wherein: R 1 is —C 1 –C 6 alkyl, C 3 –C 6 cycloalkyl, -aryl, —C 1 –C 6 alkyl-aryl, or —C 1 –C 6 alkyl-diaryl; R 2 is —H, —OH, —C 1 –C 6 alkyl unsubstituted or substituted with 1–3 R 3 , or —OR 4 ; Each R 3 is independently selected from the group consisting of —H, -halo, —CN, —C 1 –C 2 perfluoroalkyl, —C 1 –C 6 alkyl, —C 1 –C 2 perfluoroalkoxy, and —C 1 –C 6 alkoxy; R 4 is —C 1–C 6 alkyl or —C 3 –C 6 cycloalkyl; B is selected from the group consisting of R 5 is —NR 7 R 8 ; or Het where Het is selected from the group consisting of fluorooxindole, methyltriazole, [1,2]thiazinane-1,1-dioxide, azetidinyl, and wherein X is a bond, O, S, NH, N-methyl, N-propyl, N-acetyl, N-(2-hydroxyethyl), N-pyridinyl, N-pyrazinyl, N-pyrimidinyl, N-(N-morpholinyl)carbonyl, N—SO 2 Me, N-phenyl, CH(CONH 2 ), CH 2 , and CHOH, and wherein the bond attaching R 5 is made to a nitrogen atom in said Het; R 6 is —H, —C 1 –C 6 alkyl unsubstituted or substituted with 1–3 R 3 ; and R 7 and R 8 are independently —H or —C 1 –C 6 alkyl; or pharmaceutically acceptable enantiomer, diastereomer, or salt, thereof.