Patent ID: 7415306

Claim:
A system for transdermal delivery of a hydrophilic anti-emetic agent from a pharmaceutical composition comprising: an apparatus for facilitating transdermal delivery of a hydrophilic anti-emetic agent through skin of a subject, said apparatus comprises: (a) an electrode cartridge comprising at least one electrode; and (b) a main unit comprising a control unit which is adapted to apply electrical energy to the electrode when the electrode is in vicinity of the skin, enabling ablation of stratum corneum in an area beneath the electrode, thereby generating at least one micro-channel in an area on the skin of the subject; and a separate patch that does not receive electrical energy from the apparatus, the patch is adapted to be applied to the area on the skin after the at least one microchannel is generated, said patch comprising at least one hydrophilic layer comprising a hydrophilic polymer and a therapeutically effective amount of the hydrophilic anti-emetic agent in a pharmaceutical composition, devoid of permeation enhancers.