Patent ID: 8536328

Claim:
A method for preparing a compound of Formula I, comprising the step of reacting a compound of Formula IA: with a compound of Formula II: wherein X is —S— or —O—; Each n, m and a is independently selected from 0, 1, 2 or 3; X 1 is selected from absent, —S—, —O—, —S(O)—, —S(O) 2 —, —N(R 10 )—, —C(O)—, —C(OR 10 )(R 11 )—, —[C(R 10 )(R 11 )] v —, —C(R 10 )(R 11 )═C(R 10 )(R 11 )—; wherein v is 0, 1, 2, 3, 4, 5; wherein each R 10 and R 11 is independently absent, hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two R 10 and R 11 together with the atoms to which they are attached may form an additional optionally substituted, 3, 4, 5, 6 or 7 membered ring; Each R 1 , R 2 and R 3 is independently absent, hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two or more R 1 , R 2 and R 3 together with the atoms to which they are attached may form one or two additional optionally substituted, 3, 4, 5, 6 or 7 membered ring; Each R A , R B , R C , and R D is independently selected from hydrogen, halogen, —CN, NH 2 , NR 100 R 101 , SR 100 , OR 100 , aliphatic, substituted aliphatic, aryl and substituted aryl; wherein R 100 and R 101 , are independently selected from hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl; in the presence of an acid; wherein said compound of Formula IA contains a primary, secondary or tertiary amine having a pKa of about 6 to about 45.