Patent ID: 8323917

Claim:
A method of screening for a sample that comprises a compound that inhibits the activity of the GWT1 protein, wherein the compound decreases GlcN-(acyl)PI, wherein the method comprises the steps of: (1) contacting a test sample with an overexpressed protein encoded by the GWT1 gene of the following (a) or (b); (a) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO:2; (b) a DNA comprising the nucleotide sequence of SEQ ID NO: 1; (2) adding glucosaminyl-acylphosphatidylinositol (GlcN-(acyl)PI) precursor to the mixture of the test sample and the protein; (3) detecting GlcN-(acyl)PI; and (4) selecting the test sample that comprises a compound that inhibits the activity of the GWT1 protein, wherein the compound decreases GlcN-(acyl)PI.