Patent ID: 7528150

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: P is 5-isoquinolinyl; P′ is phenyl or pyridyl; R 1 and R 2 are independently selected from the group consisting of —H, halo, alkyl, alkoxy, cycloalkyl, aralkyl, aralkoxy, cycloalkylalkyl, cycloalkylalkoxy, —CN, —NO 2 , —OH, —OCF 3 , —CF 3 , —NR 4 R 5 , —S(O) m R 6 , —S(O) 2 NR 4 R 5 , —OS(O) 2 R 6 , —OS(O) 2 CF 3 , —O(CH 2 ) x NR 4 R 5 , —C(O)CF 3 , —C(O)alkyl, —C(O)cycloalkyl, —C(O)aralkyl, —C(O)Ar, —C(O)(CH 2 ) x OR 6 , —C(O)(CH 2 ) x NR 4 R 5 , —C(O)alkoxy, —C(O)NR 4 R 5 , —(CH 2 ) x C(O)alkoxy, —(CH 2 ) x OC(O)R 6 , —(CH 2 ) x OR 6 , —(CH 2 ) x NR 4 R 5 , —(CH 2 ) x C(O)NR 4 R 5 , —(CH 2 ) x N(R 4 )C(O)R 6 , —(CH 2 ) x S(O) 2 NR 4 R 5 , —(CH 2 ) x N(R 4 )S(O) 2 R 6 , -ZAr, —(CH 2 ) x S(O) 2 R 6 , —(OCH 2 ) x S(O) 2 R 6 , —N(R 4 )S(O) 2 R 6 , —N(R 4 )C(O)R 6 or —(CH 2 ) x C(O)alkyl; R 4 and R 5 may be the same or different and represent H or alkyl or R 4 and R 5 together with the nitrogen atom to which they are attached form a C 3-6 azacycloalkane, or a C 3-6 (2-oxo)azacycloalkane ring; Z represents O, S or NR 7 ; W represents a group CHR 3 or (CH 2 )CHR 3 ; R 3 represents hydrogen or alkyl; R 6 represents alkyl or phenyl; R 7 represents hydrogen, alkyl or phenyl; m represents an integer 1 or 2; n represents an integer 0, 1, 2 or 3; p and q independently represent an integer 0, 1, 2, 3 or 4; r represents an integer 0 or 1; s represents 1; t represents 1; and x represents an integer 0, 1, 2, 3, 4, 5 or 6.