Patent ID: 8491909

Claim:
A method for immunotherapy, comprising, administering to oral mucosa of a human, having an allergic response to at least one allergen, a first dose of a composition comprising a single concentration of the at least one allergen; wherein the at least one allergen is AMB a 1, house dust mite extract, cat hair extract, grass pollen extract, short ragweed pollen extract, or combinations thereof; wherein the at least one allergen is provided at a dose of at least 15 units of AMB a 1, 500 BAU of cat hair extract, 1000 AU of dust mite extract, 1000 BAU of grass pollen extract, 1:20 w/v of short ragweed pollen extract, or combinations thereof; wherein the dose of the at least one allergen does not exceed an amount that causes discomfort or adverse immune responses (maximum tolerable dose); and wherein a portion of the first dose is absorbed by the oral mucosa; administering to the oral mucosa of the human having the allergic response to the at least one allergen, one or more subsequent doses of the composition comprising a single concentration of the at least one allergen; wherein the volume of the one or more subsequent doses are larger than the first dose; wherein the first dose and each of the one or more subsequent doses are administered at the same concentration; wherein a portion of the subsequent dose is absorbed by the oral mucosa; and wherein the subsequent dose of the at least one allergen does not exceed an amount that causes discomfort or adverse immune responses; and inducing a decrease in the allergic response of the human to the at least one allergen.