Patent ID: 8853213

Claim:
A compound selected from the group consisting of a bicyclic heteroaryl compound of formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof: wherein, X is S or NR 1 , R 1 is H or C 1-4 alkyl; E is C 6-14 aryl or C 2-13 heteroaryl, wherein E is optionally substituted with one to three substituents selected from the group consisting of halogen, —NO 2 , —CN, —CF 3 , C 1-6 alkyl, C 3-8 cycloalkyl, —NH 2 , C 1-6 alkylamino, diC 1-6 alkylamino, C 1-6 alkoxy, —S—C 1-6 alkyl, —S(O) 2 —C 1-6 alkyl, —S(O) 2 —C 1-6 alkylamino, —S(O) 2 -diC 1-6 alkylamino, —C(O)—C 1-6 alkyl, carboxyl, —C(O) 2 —C 1-6 alkyl, —C(O)—C 1-6 alkylamino, —C(O)-diC 1-6 alkylamino, C 6-14 aryl, C 1-13 heteroaryl and C 2-13 heterocycloalkyl, wherein said substitutuents aryl, heteroaryl and heterocycloalkyl are optionally each independently additionally substituted with C 1-6 alkyl, halogen, diC 1-6 alkylamino or C 1-6 alkoxy; and Y is wherein, Z is O, OCH 2 or NR 2 ; wherein R 2 is —H, —OH, C 1-3 alkyl; n is 0, 1 or 2; W is —H, —C 1-6 alkyl, —C(O)—C 1-6 alkyl, —C(O)—C 6-14 aryl, —C(O)—C 1-13 heteroaryl, —C(O) 2 —C 1-6 alkyl, —C(O) 2 —C 6-14 aryl, —C(O)—C 1-6 alkylamino or C 1-13 heteroaryl, wherein said aryl and heteroaryl are optionally each independently substituted with a C 1-6 alkyl, a halogen, a C 1-6 alkoxy, or a C 3-8 cycloalkyl; W′ is —C(O)—C 1-6 alkyl, —C(O)—C 6-14 aryl or C 1-5 heteroaryl, wherein said aryl and heteroaryl are optionally each independently substituted with a C 1-6 alkyl, a halogen, a C 1-6 alkoxy, or a C 3-8 cycloalkyl; and W″ is —C(O 2 )—C 1-6 alkyl or C 1-5 heteroaryl, wherein said heteroaryl is optionally substituted with a C 1-6 alkyl, a halogen, a C 1-6 alkoxy, or a C 3-8 cycloalkyl.