Patent ID: 7329640

Claim:
A method of treating a mammal having a viral hemorrhagic fever which comprises administering to said mammal an effective amount of a Nematode-Extracted Anticoagulant Protein (“NAP”) having Factor VIIa/tissue factor inhibitory activity (“fVIIa/TF”), wherein said NAP comprises one or more NAP domains, wherein each NAP domain includes the sequence: Cys-A1-Cys-A2-Cys-A3-Cys-A4-Cys-A5-Cys-A6-Cys-A7-Cys-A8-Cys-A9-Cys-A10, wherein (a) A1 is an amino acid sequence of 7 to 8 amino acid residues; (b) A2 is an amino acid sequence of 3 to 5 amino acid residues; (c) A3 is an amino acid sequence of 3 amino acid residues; (d) A4 is an amino acid sequence of 6 to 19 amino acid residues; (e) A5 is an amino acid sequence of 3 to 4 amino acid residues; (f) A6 is an amino acid sequence of 3 to 5 amino acid residues; (g) A7 is an amino acid; (h) A8 is an amino acid sequence of 11 to 12 amino acid residues; (i) A9 is an amino acid sequence of 5 to 7 amino acid residues; and (j) A10 is an amino acid sequence of 5 to 25 amino acid residues.