Patent ID: 7087597

Claim:
A compound of the formula wherein R 1 is a heterocycle having a skeleton consisting of 8 to 12 atoms including a nitrogen atom and optionally substituted by substituent(s) selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 7-16 aralkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-14 aryl, C 1-8 alkoxy, C 1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-(C 1-5 alkyl)amino, (C 1-5 alkoxy-carbonyl)amino, (C 1-5 acyl)amino, (C 1-5 acyl)(C 1-5 alkyl)amino, C 1-5 alkylthio, nitrile, nitro, C 1-5 alkoxy-carbonyl, carboxyl, C 1-5 alkyl-carbonyloxy, oxo, thioxo, C 1-6 acyl group, sulfamoyl and (di or mono-C 1-5 alkyl)sulfamoyl; X is an oxygen atom, NH or a sulfur atom optionally oxidized with 1 or 2 oxygens, Y is a bond or a C 1-5 alkylene group, R 2 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C 1-5 alkoxy group, (4) a C 1-5 alkylthio group, (5) a carbocycle having 3 to 15 carbon atoms or (6) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s), provided that when Y is a bond, R 2 is a carbocycle having 3 to 15 carbon atoms or a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s) and; one of R 3 and R 4 is a hydrogen atom or a group of the formula: —Z—R 5 (Z is a bond or C 1-10 alkylene group optionally having substituent(s) and R 5 is (1) a hydrogen atom, (2) a hydroxy group, (3) a (C 1-5 alkoxy group, (4) a nitrile group, (5) a (C 1-5 alkoxy-carbonyl group, (6) a carboxyl group, (7) a carbamoyl group, (8) a (mono or di-C 1-5 alkyl)carbamoyl group, (9) an amino group, (10) a (di or mono-C 1-5 alkyl)amino group, (11) a (C 1-5 alkoxy-carbonyl)amino group, (12) a C 1-5 alkylthio group, (13) a carbocycle having 3 to 15 carbon atoms or (14) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s)); the other is a group of the formula: —Z—R 5 (Z and R 5 are as defined above); or R 3 and R 4 may form, together with the adjacent nitrogen atom, a heterocycle having a skeleton consisting of 3 to 15 atoms, which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle, wherein the above-mentioned heterocycle and a carbocycle having 3 to 15 carbon atoms are each optionally substituted by substituent(s) selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 7-16 aralkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-14 aryl, C 1-8 alkoxy, C 1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-C 1-5 alkyl)amino, (C 1-5 alkoxy-carbonyl)amino, (C 1-5 acyl)amino, (C 1-5 acyl)(C 1-5 alkyl)amino, C 1-5 alkylthio, nitrile, nitro, C 1-5 alkoxy-carbonyl, carboxyl, (C 1-5 alkyl-carbonyloxy, oxo, thioxo, C 1-6 acyl group, sulfamoyl and (di or mono-C 1-5 alkyl)sulfamoyl, or a salt thereof.