Patent ID: 7831392

Claim:
A process for comparing ordered segments of a first DNA map with ordered segments of a second DNA map to determine a level of accuracy of the second DNA map with respect to the first DNA map, comprising the steps of: a) receiving in a processing device the first and second DNA maps, wherein the first DNA map is a sequence DNA map generated by cutting a DNA molecule using one or more restriction enzymes, and the second DNA map is a genomic consensus DNA map in an ordered restriction DNA map; and b) validating in the processing device the level of accuracy of and the second DNA map with respect to the first DNA map based on information associated with the first and second DNA maps by comparing ordered segments of the first DNA map with ordered segments of the second DNA map using the following probability density function: Pr(D|Ĥ(σ,p c p f )) where: D is the second DNA map, Ĥ is the first DNA map, σ is a standard deviation summarizing map-wide standard deviation data, p c is a probability of a positive cut of a DNA sequence, and p f is a probability of a false-positive cut of the DNA sequence, whereby a level of accuracy the second DNA map with respect to the first DNA map is determined.