Patent ID: 8217043

Claim:
A compound of Formula I: wherein: q is 0, 1, 2 or 3; R 1 is selected from the group consisting of hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, mercapto, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, arylthio, substituted arylthio, heteroarylthio, substituted heteroarylthio, hetereocyclicthio, substituted heterocyclicthio, amino, substituted amino, and acylamino; R 2 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R 3 is selected from the group consisting of hydrogen, deuterium, alkyl, and substituted alkyl; R 4 is selected from the group consisting of hydrogen, deuterium, alkyl, and substituted alkyl; each R 5 independently is selected from the group consisting of hydroxy, cyano, halo, nitro, acyl, amino, substituted amino, acylamino, sulfonyl, substituted sulfonyl, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, carboxyl, carboxyl ester, carboxylamide, oxycarbonylamino, aminocarbonyloxy, aminocarbonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, arylthio, substituted arylthio, heteroarylthio, substituted heteroarylthio, hetereocyclicthio, substituted heterocyclicthio, heteroaryl, and substituted heteroaryl; or wherein any two adjacent R 5 groups, together with the carbon atoms attached thereto, join to form an aryl, heteroaryl or cycloalkenyl group optionally substituted with 1 to 4 substituents independently selected from halogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aryl, and substituted aryl; R 9 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 10 is —NR 11 R 12 or —OR 13 ; R 11 and R 12 independently are selected from the group consisting of hydrogen, alkyl, cycloalkyl-alkyl, C 3 -C 8 heterocyclic, aryl, and —C(O)C 1 -C 4 alkyl; or R 11 and R 12 taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic or substituted heterocyclic; and R 13 is selected from the group consisting of hydrogen and alkyl optionally substituted with one or more substituents independently selected from the group consisting of cycloalkyl, heterocyclic, aryl, and heteroaryl; or a pharmaceutically acceptable salt, single stereoisomer, mixture of stereoisomers, or tautomer thereof.