Patent ID: 8741894

Claim:
A compound of Formula I: or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, or a mixture of two or more tautomers thereof; or a pharmaceutically acceptable salt, hydrate, or prodrug thereof; wherein: R 1 , R 2 , R 3 , R 4 , and R 5 are each independently hydrogen, halo, or C 1-6 alkyl; R 6 is cyano or nitro; R 7 is hydrogen or C 1-6 alkyl; R 8 is hydrogen or C 1-6 alkyl; X is O or S; m is 0, 1, or 2; n is 1 or 2; p is 1, 2, 3, or 4; and Y is —C(O)R 1a , —C(S)R 1a , —C(O)NR 1b R 1c , —C(S)NR 1b R 1c , —C(O)OR 1e , —S(O)R 1a or —S(O) 2 R 1a ; wherein R 1a , R 1c , and R 1e are each independently (a) C 1-6 alkyl, optionally substituted with one or more halo, C 1-6 alkoxy, C 1-6 alkylthio, heterocyclyl or heteroaryl; (b) C 2-6 alkenyl, optionally substituted with one or more halo; (c) C 3-7 cycloalkyl, optionally substituted with one or more halo, or one or two C 1-6 alkyl; (d) C 6-14 aryl, optionally substituted with one or more halo, C 1-6 alkyl, where the alkyl is further optionally substituted with one, two, or three halo, or C 1-6 alkoxy, where the alkoxy is further optionally substituted with one, two, or three halo; (e) heteroaryl, optionally substituted with one or two C 1-6 alkyl; or (f) C 7-15 aralkyl optionally substituted with one or more halo, C 1-6 alkyl, where the alkyl is further optionally substituted with one, two, or three halo, or C 1-6 alkoxy, where the alkoxy is further optionally substituted with one, two, or three halo; and R 1b is hydrogen or methyl; or R 1b and R 1c together with the N atom to which they are attached form heterocyclyl; with the proviso that R 1e is not t-butyl or benzyl.