Patent ID: 7071195

Claim:
A compound of the formula wherein R 1 is independently selected from the group consisting of H; alkyl; substituted alkyl; alkoxy; halo; substituted alkoxy; hydroxy; trifluoralkyl; nitro; amino; alkylamino; cycloalkylamino; cyano; carboxy; cycloalkyl; phenyl; and substituted phenyl; R 2 is pyridyl; B 1 is hydrogen; B 2 is hydrogen; or B 1 and/or B 2 are methylene and joined together to form a five or six membered ring; Y is methylene or carbonyl; L is selected from the group consisting of R 3 is independently selected from the group consisting of C 1-6 alkyl; substituted C 1-8 alkyl; cycloalkyl; substituted cycloalkyl; naphthyl; substituted naphthyl; heteroaryl; and substituted heteroaryl; R 4 is independently selected from the group consisting of hydrogen; C 1-8 alkyl; C 1-8 alkoxy; substitued C 1-8 alkoxy; hydroxy; halogen; cyano; nitro; amino; C 1-8 alkylamino; and C 1-8 dialkylamino; R 5 is independently selected from the group consisting of hydrogen; C 1-8 alkyl; C 1-8 alkylcarbonyl; aroyl; carbamoyl; amidino; C 1-8 alkyl; C 1-8 alkylaminocarbonyl; (arylamino)carbonyl; and arylC 1-8 alkylcarbonyl; R 6 is independently selected from hydrogen and C 1-8 alkyl; n is 1–2; m is 0–3; p is 1–3; and q is 1–3; provided that when L is (N-methylene)piperazin-4-yl, then Z is phenyl or naphthyl; when L is (N-methylene)piperidin-4-yl, then Z is N-sulfonamido, N(aryl)sulfonamido, 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl, benzamido, phenylureido, phenylacetamido or (phenoxy)carbonylamino; when L is (N-methylene)-4-acetyl-piperidin-4-yl, then Z is phenyl or naphthyl and Y is carbonyl; and when L is (N-methylene)piperidin-4,4-diyl, then Z is 1-aryl-2,3-dihydro-4-oxo-imidazol-5,5-diyl and Y is carbonyl; and enantiomers, diastereomers and pharamaceutically acceptable salts thereof.