Patent ID: 8450353

Claim:
A method of treating one or more signs of skin aging associated with a loss of elastin comprising topically applying to the skin a composition effective in treating said one or more signs of skin aging associated with loss of elastin, said composition comprising: (i) an effective amount of a compound of Formula I: wherein: n is an integer from 3 to 12; X 0 and X 4 are each O; X 1 is selected from the group consisting of O, S, and NR N , where R N represents hydrogen, lower alkyl, COR 3 , CO 2 R 3 , or CH(OR 3 ) 2 ; wherein R 3 in each case is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, alkylaryl; X 2 and X 3 are each NR N , where R N represents hydrogen, lower alkyl, COR 3 , CO 2 R 3 , or CH(OR 3 ) 2 ; wherein R 3 in each case is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, alkylaryl, and heteroaryl; R 1 is selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl, alkoxyalkyl, and carboxyamidoalkyl; and R 2 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, alkylaryl, heteroaryl, alkoxy, aryloxy, and thioalkoxy; or a topically acceptable salt or prodrug thereof; and (ii) a cosmetically acceptable vehicle.