Patent ID: 7625950

Claim:
A compound of formula I wherein R 1 is C 1-6 alkyl; C 1-6 alkyl substituted by hydroxy, C 1-2 alkoxy or 1 to 6 fluorine atoms; C 2-6 alkenyl; or C 2-6 alkynyl; X is O; Y is O; R 2 is phenyl; naphthyl; C 3-6 cycloalkyl; heteroaryl; a heterocyclic residue; phenyl-C 1-2 alkyl; C 3-6 cycloalkylC 1-2 alkyl; heteroarylC 1-2 alkyl; heterocyclic-C 1-2 alkyl residue; wherein each may be ring-substituted by 1 to 5 substituents selected from hydroxy, halogen, C 1-4 alkyl, C 1-4 alkyl substituted by 1 to 5 fluorine atoms, C 3-6 cycloalkyl, C 1-4 alkoxy, C 1-4 alkoxy substituted by 1 to 5 fluorine atoms, C 3-6 cycloalkoxy, C 3-6 cycloalkylC 1-2 alkyl, cyano, phenyl, and phenyl substituted by hydroxy, halogen, C 1-4 alkyl, C 1-4 alkyl substituted by 1 to 5 fluorine atoms, C 1-4 alkoxy, C 1-4 alkoxy substituted by 1 to 5 fluorine atoms, or cyano, and where heteroaryl is a 5-to-8-membered aromatic ring comprising 1-to-4 heteroatoms selected from N, O and S, and heterocyclic is a 3-to-8-membered saturated heterocyclic ring comprising 1-to-4 heteroatoms selected from O, N and S, which ring may be fused to a phenyl; R 3 is Z—X 2 wherein Z is CH 2 , CF 2 or CF 2 and X 2 is OH or a residue of formula (a) wherein Z 1 is a direct bond, CH 2 , CHF, CF 2 or O, and each of R 8 and R 9 , independently, is H or C 1-4 alkyl optionally substituted by 1, 2 or 3 halogen atoms; and each of R 4 and R 5 , independently, is H; C 1-4 alkyl optionally substituted by 1, 2 or 3 halogen atoms; or R—CO, where R is C 1-6 -alkyl, C 3-6 -cycloalkyl, phenyl or phenyl-C 1-4 -alkyl; each of R 6 and R 7 , independently, is H; hydroxy; halogen; C 1-4 alkyl; C 1-6 cycloalkyl; C 1-4 alkoxy; C 3-6 -cycloalkoxy; C 3-6 cycloalkylC 1-2 alkyl; or cyano; and n is 2 or 3; in free form or in salt form.