Patent ID: 8637477

Claim:
A method for inhibiting expression of a target gene within a target cell, the method comprising the steps of: providing a nucleic acid molecule suitable for effecting RNAi of a target gene; providing fusion protein comprising a target binding domain for binding to a receptor on the surface of the target cell, the target binding domain comprising a hinge region, at least a portion of a C H 1 region and an Fc antibody fragment comprising a C H 2 and a C H 3 domain; an immune response domain operatively attached to the target binding domain; a first nucleic acid interaction domain corresponding to a HBV core protein or a fragment thereof operatively attached to the immune response domain; and a second nucleic acid interaction domain operatively attached at the C-terminus of the target binding domain corresponding to the HBV core protein or a fragment thereof having at least the protamine domain of the HBV core protein; and administering the nucleic acid molecule and the fusion protein to contact the target cell.