Patent ID: 8669374

Claim:
A compound having the formula: wherein Q is: R m is a substituted or unsubstituted heteroaryl; R c , and R d are independently selected from alkyl and heteroalkyl, substituted with a member selected from sulfonic acid, carboxylic acid, phosphonic acid, and phosphoric acid; each R a and each R e , is independently selected from C(O)R 9 , OR 12 , NR 12 R 13 , CR 12 C(O)R 13 , NR 12 C(O) 2 R 13 , SO 3 H, and C(O)NR 12 R 13 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, and a ring structure formed by joining a member selected from two R a moieties together with the atoms to which they are attached, two R e moieties together with the atoms to which they are attached, and a combination thereof, to form said ring structure, which is a member selected from a substituted or unsubstituted aryl and a substituted or unsubstituted heteroaryl, said ring substituted with at least one SO 3 H, wherein R 9 is a member selected from OR 10 , and NH(CH 2 ) t OR 11 wherein R 10 is a member selected from H and substituted or unsubstituted alkyl; t is selected from the integers from 1 to 12; R 11 is a member selected from H, and wherein u is selected from the integers from 1 to 8; and Y is a nucleobase; and R 12 and R 13 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl; a and e are integers independently selected from 0, 1, 2, 3 and 4; R f , R g , R h , and R i are independently selected from unsubstituted alkyl, alkylsulfonic acid, and wherein s is selected from the integers from 1 to 12; and R 9a is a member selected from OH, and NH(CH 2 ) tt —O—R 10a wherein tt is selected from the integers from 1 to 12; and R 10a is a member selected from H, a moiety comprising poly(ethylene glycol), and wherein Y is a nucleobase; and u is selected from the integers from 1 to 8.