Patent ID: 7531564

Claim:
A method of treating or inhibiting breast cancer, adenomyosis, or colon cancer, in a mammal in need thereof, which comprises providing to said mammal an effective amount of a compound of formula I, having the structure wherein R 1 is alkenyl of 2-7 carbon atoms; wherein the alkenyl moiety is optionally substituted with hydroxyl, —CN, halogen, trifluoroalkyl, trifluoroalkoxy —COR 5 , —CO 2 R 5 , —NO 2 , CONR 5 R 6 , NR 5 R 6 or N(R 5 )COR 6 ; R 2 and R 2a are each, independently, hydrogen, hydroxyl, halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-4 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, trifluoroalkyl of 1-6 carbon atoms, or trifluoroalkoxy of 1-6 carbon atoms, wherein the alkyl, alkenyl, or alkynyl moieties are optionally substituted with hydroxyl, —CN, halogen, trifluoroalkyl, trifluoroalkoxy, —COR 5 , —CO 2 RP—NO 2 , CONR 5 R 6 , NR 5 R 6 or N(R 5 )COR 6 ; R 3 , and R 3a are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, halogen, alkoxy of 1-4 carbon atoms, trifluoroalkyl of 1-6 carbon atoms, or trifluoroalkoxy of 1-6 carbon atoms; wherein the alkyl, alkenyl, or alkynyl moieties are optionally substituted with hydroxyl, —CN, halogen, trifluoroalkyl, trifluoroalkoxy, —COR 5 , —CO 2 RS, —NO 2 , CONR 5 R 6 , NR 5 R 6 or N(R 5 )COR 6 ; R 5 , R 6 are each, independently hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, X is O; or a pharmaceutically acceptable salt thereof.