Patent ID: 8877927

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, ketal, or hemiketal thereof, wherein: one of R 1 and R 2 is H, and the other is Cl; R 3 is selected from the group consisting of cyclopentyl and cyclohexyl; R 4 is an optionally substituted 5- or 6-membered monocyclic aryl or heteroaryl ring, which includes up to two heteroatoms as shown below: wherein R 41 is: H, alkyl, cycloalkyl, Ar-alkyl, Ar, OH, O-alkyl, O-cycloalkyl, O—Ar-alkyl, OAr, SH, S-alkyl, S-cycloalkyl, S—Ar-alkyl, SAr, SO-alkyl, SO-cycloalkyl, SO—Ar-alkyl, SO—Ar, SO 2 H, SO 2 -alkyl, SO 2 -cycloalkyl, SO 2 —Ar-alkyl, SO 2 Ar, NH-alkyl, NH 2 , NH-cycloalkyl, NH—Ar-alkyl, NHAr, NHCO-alkyl, NHCO-cycloalkyl, NHCO—Ar-alkyl, NHCOAr, N(alkyl) 2 , N(cycloalkyl), or N(Ar-alkyl) 2 or, NAr 2 or, when part of a CHR 41 or CR 41 group, R 41 may be halogen; B, D and G are each independently selected from the group consisting of: where R 41 is as defined above, N and N-oxide E is selected from the group consisting of: CH 2 , O, S, and N-oxide where R 41 is defined as above and R 42 is selected from the group consisting of H, alkyl, cycloalkyl, Ar and Ar-Alkyl; J and R are independently selected from the group consisting of: CR 41 , where R 41 is as defined above, N and N-oxide T 5 is selected from the group consisting of: CH and N; R 54 is C 1-6 alkyl optionally substituted by one or more C 1-6 alkoxy or C 3-6 cycloalkyl groups; and ‘q’ is 1, 2 or 3.