Patent ID: 8137553

Claim:
A dialysis treatment system capable of operating in a priming mode and a treatment mode, comprising: a. a housing defining a cavity, said cavity capable of receiving a manifold wherein said manifold comprises: i. a plastic substrate comprising a first layer and a second layer; ii. a first flow path defined by a first surface of the first layer and a first surface of the second layer; iii. a second flow path defined by a first surface of the first layer and a first surface of the second layer; and iv. a valve in fluid communication with both said first flow path and said second flow path wherein said valve has first state and a second state and wherein, when in said first state, the first flow path and second flow path are in fluid isolation and when in said second state, the first flow path and second flow path are in fluid communication v. a diaphragm molded into said manifold and positioned over said valve; and b. a valve interface physically attached to said housing, wherein said valve interface is configured to apply pressure to, or remove pressure from, said diaphragm to cause said valve to switch between said first state and said second state.