Patent ID: 6861420

Claim:
A compound of Formula I: wherein X is O, S, or N—R b ; R 1 is —Y-Q-Z; Y is heterocycle, substituted heterocycle, heteroaryl, or substituted heteroaryl, Q is absent, —O—, —S(O) m —, —NR a —, or alkylene; Z is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl, or absent provided that Q is also absent; R 2 is H, C 1-8 alkyl, or aryl(C 1-8 alkylene-); R 3 , R 4 , R 5 , and R 6 are each independently H, hydroxy, nitro, halo, cyano, N 3 , amidine, guanidine, thioguanidine, cyanoguanidine, C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 alkoxy, C 1-8 haloalkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, substituted heteroaryl, —S(O)NR c R d , —S(O) 2 NR c R d , —NR c R d , —S(O) m R a , —C(═O)NR c R d , —C(═S)NR c R d , —N(R a )—S(O)R a , or —N(R a )—S(O) 2 R a ; each R a is independently H, C 1-8 alkyl, C 1-8 alkanoyl, C 1-8 alkoxycarbonyl, aryl, aryl(C 1-8 alkylene-), heteroaryl, heteroaryl(C 1-8 alkylene-), heterocycle, or heterocycle(C 1-8 alkylene-); R b is hydrogen, C 1-8 alkyl, C 1-8 alkanoyl, C 1-8 alkoxycarbonyl, aryl, aryl(C 1-8 alkylene-), heteroaryl, heteroaryl(C 1-8 alkylene-), heterocycle, or heterocycle(C 1-8 alkylene-); each of R c and R d is independently H, C 1-8 alkyl, C 1-8 alkanoyl, C 1-8 alkoxycarbonyl, aryl, aryl(C 1-8 alkylene-), heteroaryl, heteroaryl(C 1-8 alkylene-), heterocycle, or heterocycle(C 1-8 alkylene-); or R c and R d together with the nitrogen to which they are attached form azepino, piperazino, pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each m is independently 0, 1, or 2; wherein heterocycle, heteroaryl, and substituted are as defined in the specification; or a pharmaceutically acceptable salt thereof.