Patent ID: 8518966

Claim:
A method of treating a mammal having a medical condition ameliorated by treatment with a mu opioid receptor antagonist, wherein the medical condition is opiod-induced bowel dysfunction of post-operative ileus, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: R 1 is —OR a or —C(O)NR b R c ; R 2 is C 4-10 alkyl or C 4-10 alkenyl; R 3 is C 1-6 alkyl substituted with one or two substituents selected from —OR d , —S(O) 2 R e , —NR f R g , and —C(O)R 4 ; R 4 is C 1-3 alkyl, optionally substituted with one —OR d or —S(O) 2 R e ; R a , R b , R c , R d , R f , and R g are each independently hydrogen or C 1-3 alkyl; R e is C 1-3 alkyl; and a is 1, 2, 3, 4, or 5; or a pharmaceutically-acceptable salt thereof.