Patent ID: 8222246

Claim:
A compound of formula I wherein R 1 is lower-alkyl, aryl or heteroaryl, wherein lower-alkyl is optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, hydroxy and lower-alkoxy, and wherein aryl and heteroaryl are optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, cyano, lower-alkyl, lower-alkyl substituted by halogen, lower-alkyl substituted by hydroxy, lower-alkyl-C(O)OH, lower-alkyl-C(O)O-lower-alkyl, lower-alkyl-CO—NH 2 , lower-alkyl-CO—N(H,lower-alkyl), lower-alkyl-CO—N(lower-alkyl) 2 , lower-alkyl-N(H,lower-alkyl), lower-alkyl-N(lower-alkyl) 2 , lower-alkoxy-lower-alkyl, CO-lower-alkyl, COOH, COO-lower-alkyl, CONH 2 , CON(H,lower-alkyl), CON(lower-alkyl) 2 , cycloalkyl, heterocyclyl, aryl, heteroaryl, NH 2 , N(H, lower-alkyl), N(lower-alkyl) 2 , hydroxy, lower-alkoxy, phenyloxy, SO 2 -lower-alkyl, SO 2 —NH 2 , SO 2 —N(H,lower-alkyl) and SO 2 —N(lower-alkyl) 2 ; R 2 is hydrogen or lower-alkyl; R 3 is lower-alkyl, lower-alkyl substituted by halogen, lower-alkyl substituted by hydroxy, cycloalkyl, cycloalkyl substituted by hydroxy, heterocyclyl, heterocyclyl substituted by lower-alkyl, heteroaryl, heteroaryl substituted by lower-alkyl, (CH 2 ) n —O-lower-alkyl or NR 4 R 5 ; or wherein R 2 and R 3 , together with the nitrogen atom to which they are attached, form a heterocyclyl; n is 1 or 2; R 4 and R 5 are each independently selected from hydrogen and lower-alkyl; or a pharmaceutically acceptable salt or ester thereof.