Patent ID: 7407968

Claim:
A compound of formula (I) or pharmaceutically acceptable salts thereof: wherein R F1 and R F2 are independently selected from —CF 3 , —CH 2 CF 3 , —CH 2 CHF 2 , —CHFCF 3 , —CHFCHF 2 , —CHFCH 2 F, —CF 2 CF 3 , —CF 2 CH 3 , —CF 2 CH 2 F, —CF 2 CHF 2 , —CF 3 , —CH 2 CCl 3 , —CH 2 CHCl 2 , —CH 2 CBr 3 , —CH 2 CHBr 3 , —CH 2 NO 2 , —CH 2 CH 2 NO 2 , —CH 2 CN, —CH 2 CH 2 CN, and —CH 2 CH 2 OCH 3 ; Z is selected from O═ and S═; R 1 is selected from C 1-10 alkyl; C 1-10 alkyl substituted by at least one of halogen, cyano, acetoxymethyl and nitro; C 2-10 alkenyl; C 2-10 alkenyl substituted by at least one of halogen, cyano, acetoxymethyl and nitro; C 2-10 alkynyl; C 2-10 alkynyl substituted by at least one of halogen, cyano, acetoxymethyl and nitro; R 3 R 4 N—C 1-6 alkyl; R 3 R 4 NO(═O)—C 1-6 alkyl; R 3 O—C 1-6 alkyl; R 3 OC(═O)—C 1-6 alkyl; R 3 O(═O)—C 1-6 alkyl; R 3 O(═O)NR 3 —C 1-6 alkyl; R 3 R 4 NSO 2 —C 1-6 alkyl; R 3 OSO 2 N(R 4 )—C 1-6 alkyl; R 3 R 4 NO(═O)N(R 5 )—C 1-6 alkyl; R 3 R 4 NSO 2 N(R 5 )—C 1-6 alkyl; aryl-C 1-6 alkyl; aryl-O(═O)—C 1-6 alkyl; heterocyclyl-C 1-6 alkyl; heterocyclyl-O(═O)—C 1-6 alkyl; substituted aryl-C 1-6 alkyl; substituted aryl-O(═O)—C 1-6 alkyl; substituted heterocyclyl-C 1-6 alkyl; substituted heterocyclyl-O(═O)—C 1-6 alkyl; and C 1-10 hydrocarbylamino; R 2 is selected from C 1-6 alkyl, substituted C 1-6 alkyl, C 2-6 alkenyl, substituted C 2-6 alkenyl, C 2-6 alkynyl, substituted C 2-6 alkynyl, C 3-6 cycloalkyl, substituted C 3-6 cycloalkyl, aryl, substituted aryl, and C 5-6 heteroaryl, and substituted C 5-6 heteroaryl; R 3 , R 4 and R 5 are independently selected from —H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and a divalent C 1-6 group that together with another divalent C 1-6 group forms a portion of a ring; X is selected from —NR 6 —, —C(═O)—, —CH 2 —CH 2 —, —CH═CH—, —O—, —C(R 6 )(R 7 )—, and —S(O) n —, wherein n is 0, 1 or 2, wherein R 6 and R 7 are independently C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, —OH, or —H; Ar is selected from an arylene; an heteroarylene; an arylene substituted by at least one group selected from C 1-6 alkyl, halogen, trifluoromethyl, cyano, nitro, hydroxy and C 1-6 alkoxy; and an heteroarylene substituted by at least one group selected from C 1-6 alkyl, halogen, trifluoromethyl, cyano, nitro, hydroxy and C 1-6 alkoxy; and Y is selected from —CH═ and —N═.