Patent ID: 8921560

Claim:
A compound of formula I, N-oxide, addition salt, quaternary amine, or a stereochemically isomeric form thereof; wherein each X independently is C or N; each R 1 is independently selected from the group consisting of H, halogen, C 1 -C 6 alkoxy, —CF 3 , and OCF 3 ; R 2 is selected from the group consisting of H, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, and CO(R 7 ); R 3 is —(CR 8 R 9 ) n —R 10 ; R 4 is selected from the group consisting of H, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, C 2 -C 10 alkenyl, SO 2 —R 8 , CH 2 CF 3 , SO 2 CH 3 or a 4 to 6 membered saturated ring containing an oxygen atom; R 5 is present where X is C, and is independently selected from the group consisting of H, C 1 C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, CO(R 7 ), CF 3 and halogen; R 5 is absent where X is N; R 7 is selected from the group consisting of OH, O(C 1 -C 6 alkyl), NH 2 , NHSO 2 N(C 1 -C 6 alkyl) 2 , NHSO 2 NHCH 3 , NHSO 2 (C 1 -C 6 alkyl), NHSO 2 (C 3 -C 7 cycloalkyl), and N(C 1 -C 6 -alkyl) 2 , NR 8 R 9 , NR 9 R 10 ; n is an integer from 2 to 6; R 8 and R 9 are each independently chosen from H, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl or R 8 and R 9 taken together form a 4 to 6 membered aliphatic ring that optionally contains one or more heteroatoms selected from the group N, S, O; R 10 is selected from the group consisting of H, C 1 -C 6 alkyl, OH, CN, F, CF 2 H, CF 3 , C(═NOH)NH 2 , CONR 8 R 9 , COOR 8 , CONR 8 SO 2 R 9 , CON(R 8 )SO 2 N(R 8 R 9 ), NR 8 R 9 , NR 8 COOR 9 , OCOR 8 , NR 8 SO 2 R 9 , SO 2 NR 8 R 9 , SO 2 R 8 or a 4 to 6 membered saturated ring containing an oxygen atom.