Patent ID: 7919469

Claim:
A method of reducing mucus hypersecretion in a subject suffering from a medical condition in which mucus hypersecretion is a dominant clinical finding, the method comprising administration to the airways of said subject a pharmaceutical composition comprising a mucus-inhibitory amount of a N-terminal myristoylated peptide selected from the group consisting of the MANS peptide and a N-terminal myristoylated peptide fragment thereof comprising at least the first 10 amino acids of the MANS peptide, wherein said MANS peptide consists of a N-terminal myristoylated peptide of SEQ ID NO: 1, wherein said N-terminal myristoylated peptide reduces MARCKS protein-related mucus hypersecretion, and whereby mucus hypersecretion in the airways of said subject is reduced compared to that which would occur in the absence of said peptide.