Patent ID: 7790691

Claim:
A composition comprising a first oligomeric compound and a second oligomeric compound, wherein: the first oligomeric compound is complementary to and capable of hybridizing to the second oligomeric compound and to a selected target nucleic acid; the first oligomeric compound is a compound of the formula: 5′-(N f ) 5 (N m ) 2 (N f ) 2 (N m ) 2 (N f ) 5-6 (N m ) 3 -3′ wherein: each N f is a 2′-F modified nucleoside; each N m is a 2′-OCH 3 modified nucleoside; and at least one of the 2′-fluoro modified nucleosides comprises a purine heterocyclic base; each of the first and second oligomeric compounds independently comprises from about 12 to about 30 nucleosides; and the composition optionally further comprises one or more phosphate groups, overhangs, stabilizing groups or conjugate groups.