Patent ID: RE39192

Claim:
A biocompatible, supplemented tissue sealant composition comprising: (i) at least one supplement selected from the group consisting of an antibiotic, an anesthetic, an anticoagulant, a cardiovascular drug, an anti-inflammatory compound, a cytotoxin or cell proliferation inhibiting compound, an osteogenic compound, a cartilage inducing compound, a protease inhibitor, a steroid, an analgesic, an antifungal, an antiangiogenin, an antifibrinolytic compound, an antimicrobial compound, an antiparsitic agent, an antiseptic, an antiviral compound, a chemotherapeutic drug, a lipid or liposome, an oligonucleotide or polynucleotide, an osteoconductive compound, a polysaccharide, a vascoconstrictor, a vasodilator, a vitamin, a nutritional supplement and a mineral; and (ii) fibrinogen in an amount which forms a fibrin matrix; wherein said fibrinogen forms a fibrin matrix when in the presence of thrombin and Ca ++ and water, further wherein said supplement is released from said fibrin matrix into the external environment of use for a sustained period, further wherein the amount of said supplement in said composition is greater than the amount of said supplemented which is soluble in said fibrin matrix, and further wherein said sustained period is greater than then period obtained according to simple diffusion kinetics.