Patent ID: 8545897

Claim:
A method of alleviating symptoms of, diminishing extent of, stabilizing state of, delaying or slowing progression of, amelioration of, palliation of, or causing remission of cancer, comprising administering to a mammal a compound of Formula I: or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein: A is selected from a direct bond or CR a R b ; R 1 is selected from hydrogen, halogen, C 1 -C 6 alkyl, —S(C 1 -C 6 alkyl), C 3 -C 6 cycloalkyl, a 5 or 6 membered heterocyclic, phenyl, and a 5 or 6 membered heteroaryl, wherein the alkyls, cycloalkyl, heterocyclic, phenyl or heteroaryl are optionally substituted with one or more groups selected from halogen, CN, CF 3 , C 1 -C 3 alkyl, —O(C 1 -C 3 alkyl), and NR c R d ; R 2 is selected from a saturated or partially unsaturated C 3 -C 6 cycloalkyl, phenyl, a saturated or partially unsaturated 5 or 6 membered heterocycle, a 5 or 6 membered heteroaryl, an 8 to 10 membered bicyclic aryl, an 8 to 10 membered bicyclic heterocyclic, and an 8 to 10 membered bicyclic heteroaryl, wherein the cycloalkyl, phenyl, heterocyclics, heteroaryls and aryl are optionally substituted with one or more groups selected from OH, CN, halogen, oxo (except not on phenyl, aryl or heteroaryl), CF 3 , C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), and NR e R f ; R 3 and R 4 are independently selected from hydrogen or C 1 -C 4 alkyl optionally substituted with OH, F or C 3 -C 6 cycloalkyl, or R 3 and R 4 together with the atoms to which they are attached form a 5 or 6 membered ring; R 5 is selected from hydrogen and CH 3 , or A is CR a R b , R a and R b are hydrogen, and R 3 and R 5 together with the atoms to which they are attached form a 5 or 6 membered ring; R 6 is selected from hydrogen, F, OH, —OCH 3 , and C 1 -C 3 alkyl, or A is a direct bond, R 6a is hydrogen and R 3 and R 6 together with the atoms to which they are attached form a 5 or 6 membered ring; R 6a is selected from hydrogen, F, OH, and CH 3 ; R 7 is hydrogen, or A is CR a R b and R 3 and R 7 together with the atoms to which they are attached form a 5 or 6 membered ring; R a is hydrogen, or R 4 and R b are absent and R 3 and R a together with the atoms to which they are attached form an aromatic 5 or 6 membered ring; R b is hydrogen or absent; R c and R d are independently selected hydrogen and C 1 -C 3 alkyl, or R c and R d together with the atom to which they are attached form a 5 or 6 membered ring; R e and R f are independently selected hydrogen and C 1 -C 3 alkyl; and p is 2.