Patent ID: 7166622

Claim:
A compound of Formula Ia: wherein: R 1 is selected from the group consisting of H, halogen, and O; R 2 is selected from the group consisting of H, halogen, and N═N; R 3 is selected from the group consisting of H and halogen; R 4 is selected from the group consisting of H, halogen, amino, and N═N; R 5 is selected from the group consisting of H, halogen, methoxy, methyl, and O; R 6 is selected from the group consisting of H, lower alkyl, lower alkenyl, 3-phenyl-2-propyn-1-yl, benzyl, substituted benzyl, CH 2 cycloalkyl, CH 2 -2-furan, (CH 2 ) 2 SCH 3 , and (CH 2 ) 2 NHBOC; R 8 is selected from the group consisting of a lower alkyl of S-stereochemistry at the carbon atom to which N and T are attached, cycloalkyl, CH 2 cycloalkyl, CH(lower alkyl)-2-furan, CH(lower alkyl)-4-methoxyphenyl, CH(lower alkyl)phenyl, CH(OH)-4-SCH 3 -phenyl, and (CH 2 ) 2 -S-lower alkyl; T is R 9 and R 10 are H; or R 9 is H and R 10 is selected from the group consisting of lower alkyl, lower alkenyl, CF 3 , methyl-substituted alkenyl, lower alkynyl, cycloalkyl, substituted phenyl, 1-naphthyl, and CH 2 CH 2 -1,3-dioxolane; or R 9 and R 10 are independently selected from the group consisting of lower alkyl, lower alkenyl, phenyl, 4-substituted-phenyl, and 1-naphthyl; wherein: (i) when R 5 is a methoxy; R 2 is halogen and R 1 , R 3 , and R 4 are H; (ii) when R 5 is a methyl; R 1 is halogen and R 2 , R 3 , and R 4 are H; (iii) when R 4 is an amino; R 3 is halogen and R 1 , R 2 , and R 5 are H; (iv) when R 2 is N═N, R 1 is O and R 2 is bound to R 1 to form a heterocyclic ring; (v) when R 4 is N═N, R 5 is O and R 4 is bound to R 5 to form a heterocyclic ring; (vi) one or more of R 1 to R 5 is a halogen; (vii) when R 3 is halogen, R 8 is butyl and R 9 and R 10 are H, at least one of R 1 , R 2 , R 4 , and R 5 is not H; and (viii) when R 3 is halogen, R 8 is butyl and T is —C═O, at least one of R 1 , R 2 , R 4 , and R 5 is not H; or a pharmaceutically acceptable salt, hydrate, or prodrug thereof.