Patent ID: 8901116

Claim:
A method for treating pain, anxiety or depression, comprising: administering to a patient in need of treatment thereof a therapeutically effective amount of a compound of Formula 1: or a pharmaceutically acceptable salt or hydrate thereof, wherein - - - denotes an optional bond forming a cyclic moiety; each of R 1 and R 2 is independently selected from the group consisting of H- and straight- or branched-chain C 1 -C 6 alkyl, or R 1 and R 2 are taken together to form piperidinyl or piperazinyl, or R 1 and R 2 are taken together with Ar 1 to form benzo[d][1,3]oxazin-2-one moiety; Ar 1 is selected from the group consisting of furanyl, methylenedioxyphenyl and phenyl which is optionally substituted by one or more substituents independently selected from the group consisting of H-, straight- or branched-chain C 1 -C 6 alkyl, fluoro, chloro, bromo, straight- or branched-chain C 1 -C 6 alkoxy, nitro and trifluoromethyl; z is H— or fluoro; Ar 2 is selected from the group consisting of phenyl, methylenedioxyphenyl, pyridinyl, pyrimidinyl, naphthyl, and quinoxalinyl, wherein Ar 2 is optionally substituted by one or more substituents independently selected from the group consisting of H-, straight- or branched-chain C 1 -C 6 alkyl, hydroxy, halo, straight- or branched-chain C 1 -C 6 alkoxy, nitro, acetyl, t-butylacetyl, trifluoromethyl, amino and acetyloxy; n is 1 or 2; and m is 0, 1 or 2.