Patent ID: 7071172

Claim:
A delivery vector comprising: a) an adenovirus associated (AAV) vector genome comprising 5′ and 3′ AAV inverted terminal repeat (ITR) sequences; b) a first nucleotide sequence encoding a polypeptide of interest; and c) a second nucleotide sequence encoding a fibronectin secretory signal sequence that is operatively associated with the first nucleotide sequence of (b), wherein the second nucleotide sequence is selected from the group consisting of: (i) the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:14 or SEQ ID NO:15; (ii) a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:2 or an active fragment thereof having secretory signal activity, SEQ ID NO:5 or an active fragment thereof having secretory signal activity, or SEQ ID NO:6 or an active fragment thereof having secretory signal activity; and a nucleotide sequence that differs from the nucleotide sequence of (ii) above due to the degeneracy of the genetic code, and wherein the second nucleotide sequence does not contain nucleic acids that encode fibronectin amino acid sequence beyond the carboxy terminal side of the cleavage site of the signal sequence.