Patent ID: 7754735

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof: in which R 1 is hydrogen, halogen, CN, nitro, SO 2 R 4 , OH, OR 4 , SR 4 , SOR 4 , SO 2 NR 5 R 6 , CONR 5 R 6 , NR 5 R 6 , NR 9 SO 2 R 4 , NR 9 CO 2 R 4 , NR 9 COR 4 , heteroaryl, aryl (optionally substituted by chlorine or fluorine), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 1 -C 6 alkyl, the latter three groups being optionally substituted by one or more substituents independently selected from halogen, OR 8 and NR 5 R 6 , S(O) x R 7 where x is 0, 1 or 2; R 2 is hydrogen, halogen, CN, SO 2 R 4 or CONR 5 R 6 , CH 2 OH, CH 2 OR 4 or C 1 -C 7 alkyl, the latter group being optionally substituted by one or more substituents independently selected from halogen atoms, OR 8 and NR 5 R 6 , S(O) x R 7 where x is 0, 1 or 2; R 3 is quinoline, which is optionally substituted by one or more substituents independently selected from hydrogen, halogen, CN, nitro, OH, SO 2 R 4 , OR 4 , SR 4 , SOR 4 , SO 2 NR 5 R 6 , CONR 5 R 6 , NR 5 R 6 , NR 9 SO 2 R 4 , NR 9 CO 2 R 4 , NR 9 CO 2 H, NR 9 COR 4 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1-6 alkyl, the latter three groups being optionally substituted by one or more substituents independently selected from halogen atoms, OR 8 and NR 5 R 6 , S(O) x R 7 where x=0, 1 or 2; R 4 represents aryl, heteroaryl, or C 1-6 alkyl all of which may be optionally substituted by one or more substituents independently selected from halogen atoms, aryl, heteroaryl, OR 10 and NR 11 R 12 , S(O) x R 13 (where x=0, 1 or 2), CONR 14 R 15 , NR 14 COR 15 , SO 2 NR 14 R 15 , NR 14 SO 2 R 15 ; R 5 and R 6 independently represent a hydrogen atom, a C 1-6 alkyl group, or an aryl, or a heteroaryl, the latter three of which may be optionally substituted by one or more substituents independently selected from halogen atoms, aryl, OR 8 and NR 14 R 15 , CONR 14 R 15 , NR 14 COR 15 , SO 2 NR 14 R 15 , NR 14 SO 2 R 15 ; or R 5 and R 6 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocylic ring optionally containing one or more atoms selected from O, S(O) x where x=0, 1 or 2, NR 16 , and itself optionally substituted by C 1-3 alkyl; R 7 and R 13 independently represent a C 1 -C 6 , alkyl, an aryl or a heteroaryl group all of which maybe optionally substituted by one or more halogen atoms; R 8 represents a hydrogen atom, C(O)R 9 , C 1 -C 6 alkyl an aryl or a heteroaryl group, all of which may be optionally substituted by halogen atoms or an aryl group; each of R 9 R 10 , R 11 , R 12 , R 14 , R 15 , independently represents a hydrogen atom, C 1 -C 6 alkyl, an aryl or a heteroaryl group, all of which may be optionally substituted by a halogen atom; and R 16 is hydrogen, C 1 - 4 alkyl, —COC 1 —C 4 alkyl, COYC 1 —C 4 alkyl where Y is O or NR 7 .