Patent ID: 8865150

Claim:
A bi-layer wax-film composite having a total thickness of less than 5 mm, comprising: (a) a pH-sensitive mucoadhesive layer, consisting of: ( 1 ) at least one water-insoluble swellable anionic mucoadhesive polymer of polyacrylic acid cross-linked with polyalkenyl ether or divinyl glycol; and ( 2 ) at least one anionic pH-sensitive film-forming copolymer of methacrylic acid and acrylic or methacrylic ester; (b) a water-insoluble pharmaceutical wax layer bonded to the pH-sensitive mucoadhesive layer; and (c) at least one molecule of interest; wherein the pH-sensitive mucoadhesive layer adheres to a wet mucosal surface for delivery of the molecule of interest thereto.