Patent ID: 7691415

Claim:
A method for reducing the severity of graft-versus-host disease (GvHD) caused by bone marrow transplantation in a mammal, comprising administering to the mammal: (a) bone marrow cells, and (b) isolated pluri-differentiated mesenchymal progenitor cells, wherein the isolated pluri-differentiated mesenchymal progenitor cells are obtained directly from a primary Dexter cell culture, wherein each of the pluri-differentiated mesenchymal progenitor cells simultaneously expresses a plurality of genes that are markers for multiple cell lineages, wherein the multiple cell lineages comprise at least four different mesenchymal cell lineages, wherein each of the markers is specific for a single cell lineage, and wherein the isolated pluri-differentiated mesenchymal progenitor cells are administered in an amount effective to reduce the severity of GvHD in the mammal.