Patent ID: 8754122

Claim:
A compound represented by Formula I: wherein the dashed lines indicate the presence or absence of a bond, the hatched wedges indicate the α (down) configuration, and the solid triangles indicate the β (up) configuration; B is a single, double, or triple covalent bond; n is 0-6; X is CH 2 or O; Y is CO 2 H or any pharmaceutically acceptable salt thereof; or Y is CO 2 R, CONR 2 , CONHCH 2 CH 2 OH, CON(CH 2 CH 2 OH) 2 , CH 2 OR, P(O)(OR) 2 , CONRSO 2 R, SONR 2 , or R is H, C 1-6 alkyl or C 2-6 alkenyl; R 2 and R 3 are each independently_C 1-6 linear alkyl; R 4 is hydrogen, C(═O)R, or any group that is easily removed under physiological conditions such that R 4 is effectively hydrogen; R 5 is hydrogen or R; R 6 is C 6-10 aryl or C 3-10 heteroaryl, wherein one or more carbons is substituted with N, O, or S; and which may contain one or more substituents selected from the group consisting of halogen, trihalomethyl, cyano, nitro, amino, hydroxy, C 6-10 aryl, C 3-10 heteroaryl, aryloxy, heteroaryloxy, C 1-6 alkyl, OR, SR, and SO 2 R; and the compound of Formula I is not a compound of Formula II wherein A is CO 2 H, CO 2 Me, or CO 2 Et; D is a single, double, or triple covalent bond; E is CH 2 R 7 wherein R 7 is phenyl; J is hydrogen, C(═O)R, or any group that is easily removed under physiological conditions such that R 4 is effectively hydrogen; and G is H.