Patent ID: 7141592

Claim:
A compound of the formula: or a pharmaceutically acceptable salt or ester form thereof wherein: R 1 is hydrogen or —(CH 2 ) n COOH; n is an integer from 1 to 3; X is R 2 is hydrogen, C 1 –C 8 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, aryl, benzyl, heteroaryl or —CH 2 -heteroaryl; R 3 is hydrogen, C 1 –C 8 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, phenyl, benzyl, heteroaryl or —CH 2 -heteroaryl; R 4 is hydrogen, C 1 –C 8 alkyl, —(CH 2 ) q —CH═CH 2 , —(CH 2 ) q —CH═CH-alkyl, —CH 2 ) q C≡CH, —(CH 2 ) q C≡C-alkyl, aryl, (CH 2 ) q -aryl, heteroaryl, (CH 2 ) q -heteroaryl, —CO-aryl, —CO-heteroaryl, —CO-alkyl, —SO 2 -alkyl, —SO 2 -aryl, or —SO 2 -heteroaryl; R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 14 , R 17 , R 18 and R 19 are, independently, hydrogen, halogen, C 1 –C 6 alkyl, C 1 –C 3 perfluoroalkyl, —O—C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, —OH, —NH 2 , —NO 2 , —O(CH 2 ) q -aryl, —O(CH 2 ) q -heteroaryl, aryl, or heteroaryl; R 13 is hydrogen, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, —(CH 2 ) p -aryl, —(CH 2 ) p -heteroaryl, —(CH 2 ) p —O-aryl, —(CH 2 ) p —O-heteroaryl, —(CH 2 ) p —O—(CH 2 ) m -aryl, —(CH 2 ) p —O—(CH 2 ) m -heteroaryl, aryl, or heteroaryl; q is an integer from 0 to 5; m is an integer from 0 to 5; R 15 and R 16 are, independently, hydrogen, C 1 –C 8 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, aryl, benzyl, heteroaryl or —CH 2 -heteroaryl; W is aryl or heteroaryl; and p is an integer from 1 to 5.