Patent ID: 7816318

Claim:
A pharmaceutical composition in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, a hydrocolloid emulsifying agent, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides and proteins; wherein said macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier; said Hsieh enhancer having the following structure: wherein X and Y are oxygen, sulfur or an imino group of the structure or ═N—R with the proviso that when Y is the imino group of the structure ═N—R, X is an imino group of the structure and when Y is sulfur, X is sulfur or an imino group of the structure A is a group having the structure wherein X and Y are defined above, m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, and each of R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is independently hydrogen or an alkyl group having from 1 to 6 carbon atoms which may be straight chained or branched provided that only one of R 1 to R 6 can be an alkyl group, with the proviso that when p, q and r have a value of 0 and Y is oxygen, m+n is at least 11, and with the further proviso that when X is an imino group, q is equal to 1, Y is oxygen, and p and r are 0, then m+n is at least 11.