Patent ID: 8168658

Claim:
A compound represented by Formula I: wherein X is 1) —(CR 2 2 ) n C(O)OR 1 , 2) —(CR 2 2 ) n C(O)NR 1 2 , 3) —(CR 2 2 ) n C(O)R 1 , 4) —(CR 2 2 ) n OC(O)NR 1 2 , 5) —(CR 2 2 ) n aryl, wherein aryl is optionally substituted with one or more substituents, 6) —(CR 2 2 ) n C(O)NR 1 (CR 2 2 ) m NR 1 2 , 7) —(CR 2 2 ) n C(O)NR 1 (CR 2 2 ) m NR 1 C(O)R 1 , 8) —(CR 2 2 ) n C(O)NR 1 (CR 2 2 ) n OR 1 , or 9) —(CR 2 2 ) n C(O)NR 1 (CR 2 2 ) n C(O)NR 1 2 ; Y is unsubstituted or substituted aryl or unsubstituted or substituted thienyl or pyridinyl; Z is aryl or heteroaryl; R is H or unsubstituted or substituted C 1 -C 6 alkyl; R 1 is independently selected from H, C 1 -C 6 alkyl, —(CR 2 2 ) n aryl, and —(CR 2 2 ) n heterocyclyl; wherein said alkyl, aryl or heterocyclyl is optionally substituted with one or more substituents; R 2 and R 3 are independently selected from H, unsubstituted or substituted C 1 -C 6 alkyl, and (CR 2 2 ) n aryl; R 4 is 1) —(CR 2 2 ) n NR 5 2 , 2) —(CR 2 2 ) n NR 5 C(O)R 5 , 3) —(CR 2 2 ) n NR 5 C(O)OR 5 , 4) —(CR 2 2 ) n heterocyclyl, 5) —(CR 2 2 ) n NR 5 S(O) 2 R 5 , or 6) —(CR 2 2 ) n NR 5 C(O)NR 5 2 ; wherein heterocyclyl is optionally substituted with one or more substituents; optionally, when R is unsubstituted or substituted C 1 -C 6 alkyl and R 4 is not —(CR 2 2 ) n heterocyclyl, R and R 4 may be cyclized to form a ring system; R 5 is independently selected from H, C 1 -C 6 alkyl, —(CR 2 2 ) n aryl, and —(CR 2 2 ) n heterocyclyl, wherein alkyl, aryl or heterocyclyl may be optionally substituted with one or more substituents; R 8 is unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R 12 is NH 2 , NR 5 C(O)R 5 , NR 5 C(O)OR 5 , OH, or NH-Boc; m is 1, 2 or 3; n is independently 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, or 4; s is 0, 1 or 2; or a stereoisomer or a pharmaceutically acceptable salt thereof.