Patent ID: 7415358

Claim:
A method for determining whether a test compound is a renal toxin, comprising: (a) exposing kidney tissue or kidney cells to the test compound; (b) preparing a normalized gene expression profile of at least ten genes for said kidney tissue or kidney cells, wherein the gene expression profile contains the differential gene expression values for said at least ten genes upon exposure to the test compound, and wherein said at least ten genes correspond to sequences listed in one of Tables 5-5CC; (c) comparing the gene expression profile to a renal toxicity model, the renal toxicity model comprising information from one or more of Tables 5-5CC, and comprising: (i) the normalized mean expression levels of said at least ten genes in kidney tissue or kidney cells exposed to a known renal toxin, and (ii) the normalized mean expression levels of said at least ten genes in unexposed kidney tissue or kidney cells; and (d) scoring the comparison to determine whether the test compound is a renal toxin.