Patent ID: 8546451

Claim:
A method of treating androgen deprivation therapy (ADT) induced hot flashes in a subject comprising administering a therapeutically effective amount of a compound of formula I, or its optical isomer or pharmaceutical acceptable salt, or any combination thereof: wherein Y is C(O) or CH 2 ; R 1 , R 2 are independently hydrogen, halogen, hydroxyl, alkoxy, cyano, nitro, CF 3 , N(R) 2 , sulfonamide, SO 2 R, alkyl, haloalkyl, aryl, O-Alk-NR 5 R 6 or O-Alk-heterocycle in which the heterocycle is a 3-7 membered substituted or unsubstituted heterocyclic ring, optionally aromatic; R 3 , R 4 are independently hydrogen, halogen, hydroxyalkyl, hydroxyl, alkoxy, cyano, nitro, CF 3 , NHCOR, N(R) 2 , sulfonamide, SO 2 R, alkyl, haloalkyl, aryl or protected hydroxyl; R is alkyl, hydrogen, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl, CN, NO 2 , or OH; R 5 and R 6 are independently hydrogen, phenyl, an alkyl group of 1 to 6 carbon atoms, a 3 to 7 membered cycloalkyl, a 3 to 7 membered heterocycle, a 5 to 7 membered aryl; or R 5 and R 6 form a 3 to 7 membered ring with the nitrogen atom; j and k are independently 1-4; Alk is linear alkyl of 1-7 carbons, branched alkyl of 1-7 carbons, or cyclic alkyl of 3-8 carbons.