Patent ID: 6992103

Claim:
A compound of formula (I): wherein R 1 represents a group of formula (Z a) or (Z b ): A 1 represents CH 2 , O, S or NR 5 ; A 2 represents O, S or NR 5 ; n 1 represents an integer from 1 to 3; R 5 represents hydrogen, C 1-6 alkyl optionally substituted by one or more R 11 groups, C 3-8 cycloalkyl optionally substituted by one or more R 11 groups, —C 1-2 alkyl-C 3-8 cycloalkyl or aryl; R a represents halogen; R b represents —C 1-6 alkyl optionally substituted by one or more R 11 groups, or —C 1-6 alkyl-aryl; X 1 represents N, —C(—R 6 )— or —C(—O—R 7 )—; X 2 represents N, —C(—R 8 )— or —C(—Y—R 9 )—; Y represents a bond, CH 2 , O, S, CO, NR 10 , —N(R 10 )C(O)—, —C(O)N(R 10 )—, COO, aryl, heterocyclyl or heteroaryl; R 6 represents hydrogen, halogen, —C 1-6 alkyl optionally substituted by one or more R 11 groups, —C 2-6 alkenyl, —C 3-8 cycloalkyl optionally substituted by one or more R 11 groups, —C 1-2 alkyl-C 3-8 cycloalkyl, heteroaryl, heterocyclyl or aryl; R 8 represents halogen or trifluoromethyl; R 7 , R 9 and R 10 independently represent hydrogen, —C 1-6 alkyl optionally substituted by one or more R 11 groups, —C 2-6 alkenyl, —C 3-8 cycloalkyl optionally substituted by one or more R 11 groups, —C 1-2 alkyl-C 3-8 cycloalkyl, heteroaryl, heterocyclyl or aryl; W 1 represents CO or SO 2 ; R 2 represents —C 5-8 alkyl, —C 1-6 alkyl-aryl, —C 1-6 alkyl-heteroaryl, —C 1-6 alkyl-heterocyclyl, —C 1-6 alkyl-C 3-8 cycloalkyl, —C 1-6 alkyl-S-aryl, —C 1-6 alkyl-O-aryl, —C 1-6 alkyl-S-heteroaryl or —C 1-6 alkyl-O-heteroaryl; R 3 represents —C 1-6 alkyl optionally substituted by one or more R 11 groups, or propargyl; R 4 represents —C 1-6 alkyl optionally substituted by one or more R 11 groups, —C 1-6 alkyl-aryl, —C 1-6 alkyl-heteroaryl, —C 1-6 alkyl-heterocyclyl, —C 1-6 alkyl-C 3-8 cycloalkyl, —C 3-8 cycloalkyl optionally substituted by one or more groups selected from R 11 and C 1-6 alkyl, or propargyl; w and x independently represent an integer from 0 to 2; R 11 represents halogen, hydroxy, —COOH, —COOCH 3 , C 1-6 alkoxy, cyano or amino; or a pharmaceutically acceptable salt or solvate thereof.