Patent ID: 8575070

Claim:
A method for producing a library of independent protein secondary structures, said method consisting essentially of the following sequential steps: (i) executing a computer program to thereby obtain a plurality of amino acid sequences of different proteins from bioinformatic data source(s) wherein the sequences are predicted to form secondary structures and/or assemblies of secondary structures in their native contexts; (ii) executing a computer program to simultaneously select from (i) a plurality of amino acid sequences of the different proteins, wherein the simultaneously-selected sequences each consist of a single segment of a protein corresponding to a hydrophobic folding unit is predicted to form a secondary structures independent of any other part of the protein from which it is derived when isolated from those other parts of the protein; (iii) chemically-synthesizing a plurality of peptides that each consist essentially of a sequence selected at (ii) that is predicted to form a secondary structure independent of any other part of the protein from which it is derived when isolated from other parts of the protein; and (iv) displaying a plurality of chemically-synthesized peptides that each consists essentially of a sequence selected at (iii) that is predicted to independently-form a secondary structure such that the displayed peptides form secondary structures independent of other parts of the proteins from which they are derived, thereby producing a peptide library of independent protein secondary structures.