Patent ID: 8076338

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt, hydrate, thereof, wherein, X 21 is N; X 22 is CR 23 ; X 23 is N; each of R 21 , R 22 , R 23 , R 24 , R 25 , R 26 , R 27 , R 28 , R 29 and R 30 , and each R 31 , R 32 and R 33 is independently selected from —H, halogen, trihalomethyl, —CN, —NO 2 , —NR 35 R 35a , —S(O) 0-2 R 35 , —SO 2 NR 35 R 35a , —CO 2 R 35 , —C(O)NR 35 R 35a ; —N(R 35 )S O 2 R 35 ; —N(R 35 )C(O)R 35 , —N(R 35 )CO 2 R 35 , —OR 35 , —C(O)R 35 , optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, and optionally substituted arylalkyl; R is selected from —H, halogen, trihalomethyl, —S(O) 0-2 R 35 , —SO 2 NR 35 R 35a , —CO 2 R 35 , —C(O)NR 35 R 35a , —OR 35 , —C(O)R 35 , optionally substituted lower alkyl, optionally substituted heterocyclylalkyl; or two of R 25 , R 26 , R 27 , R 28 , R 29 , R 30 , R 31 or R 32 , together with the atom or respective atoms to which they are attached, combine to form an optionally substituted spirocyclic ring system, optionally substituted fused ring system, and optionally substituted saturated bridged ring system; each of R 35 and R 35a is independently selected from —H, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted aryl, optionally substituted lower arylalkyl, optionally substituted lower aryl alkoxy, optionally substituted heterocyclyl, and optionally substituted lower heterocyclylalkyl; or R 35 and R 35a , together with the atom or respective atoms to which they are attached, combine to form an optionally substituted five- to seven-membered heterocyclyl; and m is an integer from 0 to 5; n is 1.