Patent ID: 7135586

Claim:
A compound of formula (I) the N-oxides, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein p 1 , p 2 and p 3 are integers each independently from 1 to 3; each R 1 is independently selected from hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, hydroxy, mercapto, cyano, nitro, C 1-4 alkylthio or polyhaloC 1-6 alkyl, amino, C 1-4 alkylamino and di(C 1-4 alkyl)amino; each R 2 is independently selected from hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, or trifluoromethyl; R 3 is hydrogen of C 1-4 alkyl; each R 4 is independently selected from hydrogen C 1-4 alkyl, C 1-4 alkyloxy, halo, or trifluoromethyl; Z is a bivalent radical of formula wherein n is an integer from 2 to 4 and the —(CH 2 ) n — moiety in radical (a-1) may optionally be substituted with one or two C 1-4 alkyl; R 5 and R 6 are each independently selected from hydrogen, C 1-6 alkyl or aryl; X 1 and X 2 are each N; A represents a bond, C 1-6 alkanediyl optionally substituted with one or two groups selected from aryl, and C 3-10 cycloalkyl; B represents hydrogen; C 1-10 alkyl; or aryl each optionally substituted with a group selected from halo, cyano, nitro, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkoxycarbonyl, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl; C 3-10 cycloalkyl; polyhaloC 1-6 alkyl; C 3-6 alkenyl; C 3-6 alkynyl; NR 7 R 8 ; or OR 9 ; wherein R 7 and R 8 each independently represent hydrogen, C 1-10 alkyl, or aryl each optionally substituted with a group selected from halo, cyano, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl, C 3-10 cycloalkyl, C 7-10 polycycloalkyl, polyhaloC 1-6 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, fused benzo-C 5-8 cycloalkyl, and wherein R 9 represents C 1-10 alkyl, or aryl each optionally substituted with a group selected from halo, cyano, nitro, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl; C 3-10 cycloalkyl; C 7-10 polycycloalkyl; polyhaloC 1-6 alkyl; C 3-8 alkenyl; C 3-8 alkynyl; or fused benzoC 5-8 cycloalkyl.