Patent ID: 7126028

Claim:
An enantiomerically pure compound of the formula I wherein X is N and n is 1 wherein A is an enantiomerically pure centre CH; Z is hydrogen or fluoro; and wherein R 1 is selected from hydrogen or from straight chain or branched, saturated or unsaturated C 1-8 hydrocarbon optionally substituted by one or more hydroxy, halo, aryl, cyclo C 1-8 alkyl; each R 3 is independently selected from halo, except when Z=F, then R 3 ≠F; or straight or branched chain, saturated or unsaturated C 1-4 alkyl, alkenyl, alkynyl or aryl; each optionally substituted by hydroxy, halo, saturated or unsaturated C 1-4 alkyl, alkenyl or alkynyl, aryl, cyclo C 1-6 alkyl, carbonyl, carboxyl, amino, amido; each R 2 is independently selected from hydrogen, straight chain or branched, saturated or unsaturated C 1-8 alkyl, alkenyl, or alkynyl; each optionally substituted by hydroxy, aryl, cyclo C 1-6 alkyl, carbonyl, carboxyl, amino, amido, or aryl; and one R 1 and one of R 2 together may form an alkylene group as part of a heterocyclic ring; with the proviso that when two of R 2 are hydrogen, CR 3 2 is CPh 2 and Z is hydrogen, R 1 and the other R 2 do not form together a five membered heterocyclic (pyrrolidone) ring; and wherein CR 3 2 Z does not comprise a chiral center.