Patent ID: 8809283

Claim:
A method of treating a skin disorder associated with proteasome activity selected from the group consisting of angiosarcoma, hemangioendothelioma, basal cell carcinoma, squamous cell carcinoma, malignant melanoma and Kaposi's sarcoma, psoriasis, lymphangiogenesis, hemangioma of childhood, Sturge-Weber syndrome, verruca vulgaris, neurofibromatosis, tuberous sclerosis, pyogenic granulomas, recessive dystrophic epidermolysis bullosa, venous ulcers, acne, rosacea, eczema, molluscum contagious, seborrheic keratosis, and actinic keratosis, wherein the dihydrocinnamate compound interacts with a proteasome to inhibit proteasome activity, and wherein the inhibition of proteasome activity treats the disorder, comprising administering a topical pharmaceutical composition to a patient in need thereof comprising an effective amount of a dihydrocinnamate compound and a pharmaceutically-acceptable carrier, wherein the dihydrocinnamate compound inhibits proteasome activity, and wherein the dihydrocinnamate compound is wherein W is selected from the group consisting of an alkyl group, a methylene group, an amine group, an acyl group, a carbonyl group, an oxygen atom, a sulfur atom, and wherein X 1 to X 5 are independently selected from the group consisting of a hydrogen atom, a halogen, a hydroxyl group, an ether group, a nitro group, a cyano group, a thiol group, a thioether group, an amino group, an amido group, and an OR group, where R is —C(O)—CH 2 CH 2 -phenyl, such that OR is a dihydrocinnamate moiety, and wherein at least one of X 1 to X 5 is said OR group; wherein W and XI-X4 are as defined above, or (iii) a dihydrocinnamate compound selected from the group consisting of and analogs thereof wherein one or more of the hydrogen atoms on the phenyl ring in the dihydrocinnamate moiety in the listed compounds can be replaced with a moiety selected from the group consisting of halogen, hydroxyl, ether, alkyl, aryl, nitro, cyano, thiol, thioester, amino, and amido.