Patent ID: 7473701

Claim:
A compound of the formula (IA): wherein: R1 is substituted or unsubstituted heteroaryl selected from the group consisting of thiophenyl, benzo[b]thiophenyl, indolyl, pyrrol[2,3-b]pyridinyl, furanyl, dibenzofuranyl, benzofuranvl, pyridinyl, pyrrol-1-yl, pyrrol-2-yl, pyrrol-3-yl, benzimidazolyl and quinolinyl; and Z is selected from the group consisting of alkyl, alkenyl, aryl, cycloalkyl, substituted alkyl, substituted alkenyl, substituted aryl, and substituted cycloalkyl; R is chosen from hydrogen or C1-C3 alkyl; X is selected from the group consisting of S(O 2 )—NH; S(O 2 )—O; NH—S(O 2 ); and O—S(O 2 ); or an enantiomer, stereoisomer, rotamer or a tautomer thereof, or a pharmaceutically acceptable salt or solvate thereof; with the proviso that the compound of formula (IA) is not one of the following compounds: wherein (i) Aryl is chosen from 6-(2-dimethylaminomethyl-5-methylmorpholin-4-yl)-1H-benzimidazol-2-yl, 6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl, 6-(1,4′-bipiperidin-1′-yl)-1H-benzimidazol-2-yl and 6-(N,N-dialkylamino)-1H-benzimidazol-2-yl, and Subst is independently chosen from methyl, ethyl, trifluoromethyl, phenyl, or 4-methoxyphenyl, (ii) Aryl is thien-2-yl and Subst is 3,5-bis(trifluoromethyl)phenyl.