Patent ID: 7700765

Claim:
A compound of formula I, wherein R 1 represents Het 1 , R 1a C(O)— or D-A-N(H)-[Q] n -C(O)-E-C(O)—; R 1a represents: H, aryl optionally substituted by one or more substituents selected from the group consisting of OH, halo, cyano, nitro, N(R 3a )R 3b , C 1-4 alkyl and C 1-4 alkoxy), aromatic or part-aromatic C 13-14 tricyclic carbocyclyl optionally substituted by one or more substituents selected from the group consisting of OH, halo, cyano, nitro, N(R 3a )R 3b ,C 1-4 alkyl and C 1-4 alkoxy, and when the C 13-14 tricyclic carbocyclyl is part-aromatic, a non-aromatic part of the C 13-14 tricyclic carbocyclyl is optionally substituted by one or two oxo groups or C 1-12 alkyl optionally substituted and/or terminated by one or more substituents selected from the group consisting of halo and aryl, wherein the aryl is optionally substituted by one or more substituents selected from the group consisting of OH, halo, cyano, nitro, N(R 3a )R 3b , C 1-4 alkyl and C 1-4 alkoxy; A represents C 2-6 alkylene or A 1 -C(O)N(H)-A 2 , wherein A 2 is attached to D; A 1 represents C 1-4 alkylene; A 2 represents C 2-5 alkylene; D represents —N(R 2a )R 2b , —C(═NR 2c )N(R 2d )R 2e or —N(R 2f )C(═NR 2g )N(H)R 2h ; R 2a and R 2b independently represent H, C 1-6 alkyl, Het 2 or R 2a and R 2b together represent (CH 2 ) 3-6 , wherein the (CH 2 ) 3-6 is optionally interrupted by NR 4 and/or is optionally substituted by one or more C 1-4 alkyl groups; R 4 represents H, C 1-6 alkyl or Het 3 ; R 2c to R 2h independently represent H or C 1-6 alkyl; E represents -E 1 -Het 4 -, E 2a , —(CH 2 ) 0-3 N(H)C(O)-E 2b -C(O)N(H)(CH 2 ) 0-3 — or is represented by the formula E 3 represents (CH 2 ) 1-2 , CH═CH, CH═N, CH 2 —N(R a ), (CH 2 ) 0-1 C(O), (CH 2 ) 0-1 O or (CH 2 ) 0-1 S; R a represents H or C 1-6 alkyl; E 1 represents (CH 2 ) 0-2 or CH═CH; E 2a and E 2b independently represent C 2-4 alkenylene, C 3-6 cycloalkylene, phenylene or naphthylene; Het 1 to Het 4 independently represent four- to twelve-membered heterocyclic groups containing one or more heteroatoms selected from N, O and S, which heterocyclic groups are optionally substituted by one or more substituents selected from the group consisting of ═O, OH, halo, cyano, nitro, N(R 3a )R 3b , C 1-4 alkyl and C 1-4 alkoxy; R 3a and R 3b independently represent, H or C 1-4 alkyl, or R 3a represents —C(O)R 5 ; R 5 represents H or C 1-4 alkyl; n represents, 2, 3, 4 or 5; each individual Q independently represents a structure represented by formula Ia, Ib, Ic, Id, Ie or If wherein R 6 represents H or C 1-6 alkyl; R 7 represents C 1-12 alkyl; R 8 , R 9 , R 10 and R 11 independently represent H or C 1-12 alkyl; G represents CH or N; L represents O or S; and p, q and r independently represent 0, 1, 2 or 3; provided that the compound comprises at least one structure represented by formula Ib, Ic, Id, Ie or If in which R 6 or R 7 , R 8 , R 9 , R 10 or R 11 , respectively, represents branched, cyclic or part cyclic C 3-5 alkyl; or a pharmaceutically acceptable derivative thereof.