Patent ID: 8399674

Claim:
A compound of formula I wherein R 1 is —NR a —Ar 1 , —NR b CH 2 —Ar 1 , —CH 2 NR b —Ar 1 , —NR c C(O)—Ar 1 , —OCH 2 —Ar 1 , —CH 2 O—Ar 1 , —CH 2 CH 2 —Ar 1 , —CH═CH—Ar 1 , —NHC(O)NH—Ar 1 , —NHSO 2 NH—Ar 1 , —NR c C(O)O—Ar 1 , —C(O)NR c CH 2 —Ar 1 , —CH 2 NR b CH 2 —Ar 1 , —NHC(═N—Ar 1 )—Ar 1 , —NR b CH 2 CH 2 CH 2 —Ar 1 , or —NR b CH 2 CH 2 O—Ar 1 , R 2 is —Ar 2 , —CHR d —Ar 2 , or —CH 2 CH 2 O—Ar 2 , R 3 is hydrogen, phenyl, or pyridinyl, optionally substituted with one or more C 1-4 -alkyl, halo, or C 1-4 -alkoxy, —NR e R f , wherein R e and R f are each independently hydrogen, or —(CH 2 ) m —OR g , wherein m is from 2 to 6, Ar 1 and Ar 2 are each independently aryl or heteroaryl, each optionally substituted by one or more B, B is C 1-7 -alkoxy, C 1-7 -haloalkoxy, hydroxy, halo, C 1-7 -alkyl, optionally substituted with one or more halo, hydroxy, or cyano, —S(O) 2 —C 1-7 -alkyl, —NR i R ii , —NR iii S(O) 2 R iv , —NR iii C(O)R iv , —C(O)NR iii R iv , —S(O) 2 —NR iii R iv , —CH 2 —O—R v , —(OCH 2 CH 2 ) n —OR v , wherein n is from 1 to 3, —CH 2 —(OCH 2 CH 2 ) n —OR v , wherein n is from 1 to 3, —C(O)R v , cyano, nitro, allyl, C 3-7 -cycloalkyl, 5- to 7-membered monocyclic heterocycloalkyl, or two residues B in ortho-position to each other form a 3- to 4-membered bridge of the formula —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, —O—C(R vi ) 2 —O—, —OCH 2 CH 2 O—, —OCH(R vii )CH(R viii )—, R a , R b , R c , R d , and R g are each independently hydrogen or C 1-7 -alkyl; R i , R ii , R iii , R iv , and R v are each independently hydrogen, C 1-7 -alkyl or —(CH 2 ) n —C 3-7 -cycloalkyl, wherein n is from 0 to 3; R vi , R vii , and R viii are each independently hydrogen, C 1-4 -alkyl or halogen; or a pharmaceutically acceptable salt thereof.