Patent ID: 8129427

Claim:
A compound of formula I wherein: J is hydrogen; W is a group A-[(CH 2 ) n —O] r — wherein: n is zero, 1 or 2; and r is zero or 1; A is (C 1 -C 4 )alkyl, trifluoromethyl; cyclopropyl; cyclopentyl; phenyl optionally substituted with a group selected from halo, methyl, methoxy, trifluoromethyl, acetylamino, and dimethylaminomethyl; thienyl optionally substituted with a chloro group; furanyl; isoxazolyl optionally substituted with one or two methyl groups; piperidinyl; morpholinyl; pyridinyl or pyrimidinyl, the pyridinyl and pyrimidinyl ring being optionally substituted with one or two methoxy groups; R is hydrogen; or fluoro; R 0 is hydrogen; or (C 1 -C 2 )alkyl; R 1 is cyclopropylmethyl; furanylmethyl; tetrahydrofuranyl; or tetrahydrofuranylmethyl; R 2 is hydrogen; or (C 1 -C 4 )alkyl; R 3 is hydrogen; or (C 1 -C 4 )alkyl; and R 4 is hydrogen; (C 1 -C 4 )alkyl optionally substituted with a group selected from (C 1 -C 2 )alkoxy, amino, (C 1 -C 4 )alkylamino and di-(C 1 -C 4 )alkylamino; or heterocyclyl wherein the heterocyclyl is selected from isoxazolyl, pyrazolyl, imidazolyl, thiazolyl and 1,3,4 thiadiazolyl and may be optionally substituted with a (C 1 -C 2 )alkyl group; or R 3 and R 4 taken together with the adjacent nitrogen atom form a pyrrolidine ring; with the proviso that when A is (C 1 -C 4 )alkyl, trifluoromethyl, cyclopropyl or cyclopentyl, then r is 1; either as a single optical isomer or mixtures thereof, or pharmaceutically acceptable salts of the single optical isomer or mixtures thereof.