Patent ID: 7335635

Claim:
A method of enhancing the death of a neoplastic cell in vitro comprising providing to said neoplastic cell a therapeutically effective amount of a 14-3-3 antagonist and at least one antineoplastic therapeutic agent, wherein said 14-3-3 antagonist is a 14-3-3 amphipathic groove binding antagonist, and wherein said 14-3-3 antagonist is selected from the group consisting of: a) an amino acid sequence having at least 80% sequence identity across the entirety of SEQ ID NO:2, wherein said sequence disrupts the interaction between a 14-3-3 polypeptide and a 14-3-3 ligand and, b) an amino acid sequence having at least 25 contiguous amino acids of SEQ ID NO:2, wherein said sequence disrupts the interaction between a 14-3-3 polypeptide and a 14-3-3 ligand; wherein said enhancement is relative to the death of a neoplastic cell by administration of either of said antineoplastic agent or said 14-3-3 antagonist alone.