Patent ID: 8207216

Claim:
A compound of formula: and pharmaceutically acceptable salts, and esters thereof, where: C and D are selected from: where w and z are 1 or 0, and w and z are not both 0; where doted lines in the central ring above and in the group indicate single or double bonds as appropriate to satisfy valency; R 1 and R 2 are independently selected from hydrogen, alkyl,alkenyl, alkynyl, aryl, heterocyclic, arylalkyl, heteroaryl, heteroarylalkyl, alkoxyalkyl, aryloxyalkyl, aminoalkyl, hydroxyalkyl, haloalkyl, thioalkyl, thioalkoxy, ether or thioether; R 3 is selected from alkyl, alkenyl, alkynyl, aryl, heterocyclic, arylalkyl, heteroaryl, heteroarylalkyl, alkoxyalkyl, aryloxyalkyl, aminoalkyl, hydroxyalkyl, haloalkyl, thioalkyl, thioalkoxy, ether or thioether; R 5 is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclic, arylalkyl, heteroaryl, heteroarylalkyl, alkoxyalkyl, aryloxyalkyl, aminoalkyl, hydroxyalkyl, haloalkyl, thioalkyl, thioalkoxy, ether or thioether; R 6 takes any value of R 3 or —OR 4 , where R 4 is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclic, arylalkyl, heteroaryl, heteroarylalkyl, alkoxyalkyl, aryloxyalkyl, aminoalkyl, hydroxyalkyl, haloalkyl, thioalkyl, thioalkoxy, ether or thioether and X and Y represent one, two, three or four non-hydrogen substituents on the indicated ring, wherein each X and Y is independently selected from halogen, —OH, —CN, —NO 2 , alkyl, alkenyl, alkynyl, aryl, heterocyclic, heteroaryl, —OR′, —N(R) 2 , —N(R) 3 + , —CO—N(R) 2 , —NHCO—R, —NR′—CO—R, —NR—CO—N(R) 2 , —CS—N(R) 2 , —NHCSR, —NR′—CS—R, —NR—CS—N(R) 2 , amidine, —COH, —CO—R′, —CO 2 H, —CO 2 − , —CO 2 R′, —CS—R, —OCO—R, —SO 2 N(R) 2 , —NR—SO 2 R, —SO 2 —R, —SO—R, —SH or —SR; and X and Y may also be hydrogens except that when R 1 is methyl and R 2 is hydrogen or methyl at least one of the X or Y substituents is a non-hydrogen substituent; where each R is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl or arylalkyl groups and each R′ is independently selected from alkyl, alkenyl, alkynyl, aryl or arylalkyl groups; wherein two X or two Y, substituted ortho to one another on the indicated ring, optionally can together form a 5- to 8-member carbon ring between the points of attachment of the X's and Y's, which ring may contain one or two heteroatoms; wherein one of R 3 , R 4 , or R 5 together with one of X or Y substituted at the 4-position on the indicated ring, can together form a carbon ring which ring may contain one or two heteroatoms, and wherein any carbon atoms of any R 1 , R 2 , X, Y, R and R′ group are optionally substituted with one or more halogens, —OH, —CN, alkyl, alkenyl, alkynyl, aryl, heterocyclic, heteroaryl, OR′, —N(R) 2 , —N(R) 3 + , —CO—N(R) 2 , —NHCO—R, —NR′—CO—R, —NR—CO—N(R) 2 , —CS—N(R) 2 , —NHCSR, —NR′—CS—R, —NR—CS—N(R) 2 , amidine, —COH, —CO—R′, —CO 2 H, —CO 2 − , —CO 2 R′, —CS—R, —OCO—R, —SO 2 N(R) 2 , —NR—SO 2 R, —SO 2 —R, —SO—R, —SH or —SR.