Patent ID: 7579008

Claim:
A method of inducing an immune response against a rotavirus a G1 serotype and a rotavirus from at least one non-G1 serotype selected from the group of: G2, G3, G4, and G9 serotypes, said method comprising the step of administering to a subject a composition comprising a single rotavirus variant from an attenuated human rotavirus strain from a G1 serotype, wherein the single rotavirus variant comprises: a VP4 gene comprising a nucleotide sequence comprising an adenine base (A) at position 788; an adenine base (A) at position 802; and a thymine base (T) at position 501 from the start codon; and a VP7 gene comprising a nucleotide sequence comprising a thymine (T) at position 605; an adenine (A) at position 897; and an adenine (A) at position 108 from the start codon.