Patent ID: 8871732

Claim:
A method of modulating an immune response in a mammal comprising: administering to a mammal an immunomodulatory polynucleotide (IMP) in an amount sufficient to modulate an immune response in said-mammal, wherein said IMP comprises: (SEQ ID NO: 156) a) 5′-N x (TCG(N q )) y N w (X 1 X 2 CGX 2 ′X 1 ′CG) p ) z wherein N are nucleosides, x=0-3, y=1-4, w=−2, −1, 0, 1 or 2, p=0 or 1, q=0, 1 or 2, and z=1-20, X 1 and X 1 ′ are self-complimentary nucleosides, X 2 and X 2 ′ are self-complimentary nucleosides, and wherein the 5′ T of the (TCG(N q )) y sequence is 0-3 bases from the 5′ end of the polynucleotide; and b) a palindromic sequence at least 8 bases in length wherein the palindromic sequence comprises the first (X 1 X 2 CGX 2 ′X 1 ′) of the (X 1 X 2 CGX 2 ′X 1 ′(CG) p ) z sequences, and wherein the mammal has cancer.