Patent ID: 8008309

Claim:
A compound of Formula (D) having the structure: wherein: L a is CH 2 , O, NH or S; Ar is a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl; Y is an optionally substituted group selected from among alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; Z is C(═O), OC(═O), NRC(═O), C(═S), S(═O) x , OS(═O) x , NRS(═O) x , where x is 1 or 2; R 7 and R 8 are each H; or R 7 and R 8 taken together form a bond; R 6 is H; R is H or C 1 -C 6 alkyl; or pharmaceutically acceptable salts thereof.