Patent ID: 8383381

Claim:
A process for producing an N-(5-hydroxy-2-adamantyl)-benzamide compound, comprising contacting a compound selected from the group consisting of i) an N-(2-adamantyl)-benzamide, ii) an N-(2-adamantyl)-benzamide compound, wherein a benzene ring part is substituted with halogen, alkyl, hydroxy, alkoxy, nitro, aryl, arylalkyl, carboxy, ester or carbamoyl, iii) an N-(2-adamantyl)-benzamide compound wherein a part, other than a part to be hydroxylated, of an adamantyl group is substituted with halogen, alkyl, hydroxy, alkoxy, nitro, aryl, arylalkyl, carboxy, ester or carbamoyl; and iv) an N-(2-adamantyl)-benzamide compound wherein a benzene ring part and an adamantane part are substituted with the aforementioned substituents; with a cytochrome P450, wherein the cytochrome P450 is a polypeptide having 95% or more homology with the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 3.