Patent ID: 7625889

Claim:
A compound, including enantiomers, stereoisomers, and tautomers of said compound and pharmaceutically acceptable salts thereof, with said compound having the general structure shown in formula I: wherein: denotes a single bond between X and Y; X is O or S; Y is CHR or CO; Z is NR; A, B and E are the same or different and independently from each other are CR; D is either CH 2 or CO; Ar is selected from the group consisting of substituted or unsubstituted phenyl, pyridinyl, pyrazinyl, furanyl and thiophenyl wherein the substituents are selected from the group consisting of fluorine, chlorine, C 1-4 alkyl, C 1-4 alkoxy and —CF 3; each R is independently chosen from hydrogen, halogen, CN, C(O)NR 3 R 4 , C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkenyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1; wherein R 3 and R 4 are hydrogen or C 1 alkyl; and R 1 and R 2 taken together with the nitrogen atom to which they are attached form an unsubstituted or at least monosubstituted piperazine or diazepane; and wherein the substituents are selected from the group consisting of phenyl, fluorophenyl, trifluoromethylphenyl, pyridinyl, thiophenyl, furanyl C 3-8 cycloalkyl, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkenyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, —NO 2 , —NH 2 , —NH(C 1-4 alkyl), —N(C 1-4 alkyl) 2 , —CN, —C(O)R 5 , —NHC(O)(C 1-4 alkyl), —SO 2 Cl, —SO 2 (C 1-4 alkyl), halogen and hydroxy; wherein R 5 is hydroxy, C 1-3 alkoxy, —O-phenyl, —NH 2 , —NH(C 1-3 alkyl), —N(C 1-3 alkyl) 2 or phenyl.