Patent ID: 7652018

Claim:
A compound of the structure: wherein: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are, independently, H, C 1 to C 10 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) q —O—(CH 2 ) n -aryl, —(CH 2 ) n C(H) 3-p (R 7 ) p , —(CH 2 ) n COOR 8 , or —(CH 2 ) p —O—R 9 ; or R 1 , R 2 or R 3 , R 4 or R 5 , R 6 are taken together to form a 3 to 6 membered cycloalkyl ring; or when m is 0, R 1 or R 2 forms a 5 to 7 membered cycloalkyl ring with R 5 or R 6 ; or when m is 0, R 1 or R 2 forms a 6-membered aryl ring with R 5 or R 6 ; R 7 is halogen; R 8 is C 1 to C 6 alkyl; R 9 is H, C 1 to C 6 alkyl, or C 1 to C 3 perfluoroalkyl; R 10 is H, C 1 to C 6 alkyl, or —(CH 2 ) n -aryl; V is O or S; X and Z are, independently, N or CR 14 ; R 14 is H, C 1 to C 6 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) n —O—(CH 2 ) n -alkyl, —(CH 2 ) n —O—(CH 2 ) n -aryl, halogen, hydroxy, C 1 to C 3 perfluoroalkyl, C 1 to C 3 perfluoroalkoxy, or —(CH 2 ) n —CN; Y is O or S; Q is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; m is 1; n is 0 to 3; p is 1 to 3; q is 1 to 4; or a pharmaceutically acceptable salt thereof.