Patent ID: 8440649

Claim:
A method for treating a coronavirus infection, comprising administering to a subject in need thereof an effective amount of a compound of Formula I, wherein n is 1, 2 or 3; each of and , independently, is a single bond or a double bond; each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , and R 15 , independently, is H, halogen, alkyl, aryl, cyclyl, heteroaryl, heterocyclyl, OH, alkoxy, carbonyloxy, or amino; each of R 16 and R 17 , independently, is H, halogen, alkyl, aryl, cyclyl, heteroaryl, heterocyclyl, OH, alkoxy, carbonyloxy, or amino, or R 16 and R 17 together are a single bond; and when is a single bond, X is C═O or CR′R″ and Y is N or N + →O − , and when is a double bond, X is CR′, Y is N + , and a counterion coexists in the compound; each of R′ and R″, independently, being H, halo, alkyl, aryl, cyclyl, heteroaryl, heterocyclyl, OH, alkoxy, or amino, and the coronavirus infection is caused by human CoV 229E, transmissible gastroenteritis virus, bovine CoV, feline CoV, or severe acute respiratory syndrome-associated coronavirus.