Patent ID: 7470658

Claim:
A method of inhibiting a carbohydrate or an antibody from binding to a selectin comprising contacting the selectin with a peptide comprising: a heptapeptide selected from the group consisting of -IX 1 LX 2 QX 3 R- (SEQ ID NO:1); -X 1 X 2 LLX 3 AR- (SEQ ID NO:2); -IX 1 LLX 2 X 3 R- (SEQ ID NO:33), -IX 1 LX 2 QAR- (SEQ ID NO:3); -IX 1 LLQX 2 R- (SEQ ID NO:4); -IX 1 LLX 2 AR- (SEQ ID NO:5); and -IXLLQAR- (SEQ ID NO:6); a hexapeptide selected from the group consisting of -X 1 LX 2 QX 3 R- (SEQ ID NO:14), -X 1 LX 2 QAR- (SEQ ID NO:15), -X 1 LLX 2 AR- (SEQ ID NO:16), and -X 1 LLQX 2 R- (SEQ ID NO:17); or a pentapeptide selected from the group consisting of -LX 1 QX 2 R- (SEQ ID NO:24), -LXQAR- (SEQ ID NO:25), -LLXAR- (SEQ ID NO:26), and -LLQXR- (SEQ ID NO:27), wherein said peptide has no more than about 250 amino acids and wherein the heptapeptide, hexapeptide or pentapeptide sequence of said peptide inhibits binding to sialyl Lewis a (sLe a ) or sialyl Lewis x (sLe x ).