Patent ID: 6897211

Claim:
A compound of formula I or pharmacologically acceptable salts thereof and hydrates thereof wherein X represents CH 2 , or a heteroatom selected from the group consisting of O, S, S(═O), S(═O) 2 or NR 13 wherein R 13 is hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, arylcarbonyl, C 1-6 alkylsulfonyl, or arylsulfonyl; each R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 , independently represents hydrogen, fluoro, chloro, bromo; or C 1 -C 7 alkyl, C 2 -C 7 alkenyl; monocyclic or bicyclic aryl group having from 6 to 10 carbon atoms and alternating double bonds between carbon atoms and said aryl group can be unsubstituted or substituted with fluoro, chloro, bromo, hydroxy, C 1 -C 7 alkyl, C 1 -C 7 alkoxy, aryloxy, wherein aryl has the meaning as defined above, C 1 -C 7 alkylthio, arylthio wherein aryl has the meaning as defined above, C 1 -C 7 alkylsulfonyl, cyano, or amino; C 1 -C 7 mono or di-C 1 -C 7 substituted amino, heteroaryl which is a monocyclic or bicyclic aromatic hydrocarbon containing at least one heteroatom selected from O, S or N optionally said heteroaryl can be unsubstituted or substituted with fluoro, chloro, bromo, CF 3 , methyl, ethyl or propyl; or halomethyl, hydroxy, C 1 -C 7 alkoxy, aryloxy wherein aryl has the meaning as defined above, C 1 -C 7 alkylthio, arylthio wherein aryl has the meaning as defined above, C 1 -C 7 alkylsulfonyl, cyano, amino, C 1 -C 7 mono- or di-C 1 -C 7 substituted amino, C 1 -C 7 hydroxycarbonyl, C 1 -C 7 alkanoyloxycarbonyl, carbamoyl, mono-N-(C 1 -C 7 )alkylcarbamoyl, di-N,N-(C 1 -C 7 )alkylcarbamoyl, C 1 -C 7 alkyloxycarbonyl, aryloxycarbonyl, C 1 -C 7 alkylcarbonyl, arylcarbonyl; R 10 represents C 2 -C 15 alkyl, C 2 -C 15 alkenyl, C 2 -C 15 alkynyl, aryl or heteroaryl wherein aryl and heteroaryl have the meaning as defined above, C 1 -C 15 haloalkyl, C 1 -C 15 hydroxyalkyl, C 1 -C 15 alkyloxy, C 1 -C 15 alkylthio, C 3 -C 15 alkylcarbonyl, C 2 -C 15 hydroxycarbonyl, C 3 -C 15 alkyloxycarbonyl, C 1 -C 15 alkylsulfonyl, arylsulfonyl or C 1 -C 15 alkylarylsulfonyl wherein aryl has the meaning as defined above, CH═CHCH 2 OH, CH═CHCH 2 O(CH 2 ) n -A, or C 1 -C 15 alkylamino represented by the formula (CH 2 )n-A wherein n is an integer from 1 to 15, optionally one or more methylene groups can be substituted with an oxygen or sulphur atom A represents saturated or unsaturated a five- or six-membered ring having from one to three heteroatoms selected from the group consisting of O, S, N or combinations thereof, or a group of the formula wherein R 11 and R 12 independently represent hydrogen, C 1 -C 7 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, aryl or heteroaryl wherein aryl and heteroaryl have the meaning as defined above, or a saturated or unsaturated five- or six-membered ring having from one to three heteroatoms selected from the group consisting of O, S, N or combinations thereof.