Patent ID: 8487108

Claim:
A compound represented by the following structural formula or a salt thereof, wherein Z is —O— or —CH 2 —; X 1 is a covalent bond, —O—, —S—, —S(O)—, or —S(O) 2 —; Y 1 is a covalent bond, C 1 -C 10 alkylene, C 2 -C 10 alkenylene or C 2 -C 10 alkynylene, each optionally substituted at one or more substitutable carbon atom with halogen, cyano, hydroxyl, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy or halo(C 1 -C 3 )alkoxy, provided that Y 1 is a covalent bond only when X 1 is a covalent bond; n is 0, 1, 2 or 3; E with the ring nitrogen that it protects is a carbamate, amide or sulfonamide; R 2 is —NHC(O)OR 9 ; R 3 is —H, C 1 -C 5 alkyl, —NHC(O)R 10 , or —OR 10 , wherein R 10 is C 1 -C 3 alkyl; R 9 is a straight or branched C 1 -C 5 alkyl, straight or branched C 1 -C 5 haloalkyl, (C 3 -C 4 )cycloalkyl or straight or branched C 1 -C 5 alkoxyalkyl; and R 11 is 1) fluorine, chlorine, bromine, cyano, nitro, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 4 -C 7 )cycloalkylalkyl, (C 2 -C 6 )alkenyl, (C 5 -C 7 )cycloalkylalkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 6 )cycloalkyl(C 2 -C 4 )alkynyl, halo(C 1 -C 6 )alkyl, halo(C 3 -C 6 )cycloalkyl, halo(C 4 -C 7 )cycloalkylalkyl, halo(C 2 -C 6 )alkenyl, halo(C 3 -C 6 )alkynyl, halo(C 5 -C 7 )-cycloalkylalkynyl, (C 1 -C 6 )alkoxy, (C 3 -C 6 )cycloalkoxy, (C 4 -C 7 )cycloalkylalkoxy, halo(C 1 -C 6 )alkoxy, halo(C 3 -C 6 )cycloalkoxy, halo(C 4 -C 7 )cycloalkylalkoxy or (C 1 -C 6 )alkanesulfonyl; or 2) phenyl, heteroaryl, phenoxy, heteroaryloxy, phenylthio, heteroarylthio, benzyl, heteroarylmethyl, benzyloxy or heteroarylmethoxy, each optionally substituted with 1 to 3 groups independently selected from: fluorine, chlorine, cyano, (C 1 -C 3 )alkyl, halo(C 1 -C 3 )alkyl, (C 1 -C 3 )-alkoxy, halo(C 1 -C 3 )alkoxy, and aminocarbonyl.