Patent ID: 7501508

Claim:
A method of making a porphyrin of Formula I: wherein: A and B are each independently H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, alkoxy, halo, mercapto, azido, cyano, hydroxyl, nitro, acyl, alkoxy, alkyhhio, amino, alkylamino, arylalkylamino, disubstituted amino, acylamino, acyloxy, amide, sulfonamide, urea, alkoxylacylamino, aminoacyloxy, hydrophilic groups, surface attachment groups, cross-coupling groups or bioconjugatable groups; R 1 is selected from the group consisting of H, alkyl and aryl; R 2 , R 3 , R 4 , R 5 , R 7 , R 8 , R 9 , and R 10 are each independently selected from the group consisting of H, halo, loweralkoxy, and loweralkylthio; and M is a metal or a pair of hydrogen atoms; said method comprising: (a) condensing (i) a 1,9-bis(N,N-dialkylaminomethyl)dipyrromethane of Formula II: wherein R a and R b are each independently selected loweralkyl and A, R 1 , R 2 , R 3 , R 4 , and R 5 are as given above, with (ii) a dipyrromethane of Formula III: wherein B, R 7 , R 8 , R 9 and R 10 are as given above in an alcohol solvent containing a metal salt to produce a reaction product; and then (b) oxidizing said reaction product with an oxidizing agent and then (c) optionally demetallating said reaction product to produce the porphyrin of Formula I.