Patent ID: 8742110

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein each occurrence of Ra is independently selected from the group consisting of hydrogen, halogen, —C 1 -C 10 alkyl and halogen-substitutedC 1 -C 10 alkyl; R 1 is selected from the group consisting of hydrogen, phenyl and heterocycle, wherein the phenyl or heterocycle is substituted with at least one substituent selected from α; R 2 is selected from the group consisting of aryl and heterocycle, wherein the aryl or heterocycle is substituted with 1-5 substituents independently selected from α; α is selected from the group consisting of: halogen, —C 1 -C 10 alkyl, —C 3 -C 10 cycloalkyl, heterocycle, aryl, —OH, —O—C 1 -C 10 alkyl, —O—C 3 -C 10 cycloalkyl, —O-aryl, —O-heterocycle, —NRbS(O) 2 Rc, —NRbRc, —CN, —NRbC(O)Rc, —S(O) 2 Rb, —S(O) 2 NRbRc, —C(O)NRbRc, —C(O)NRb(C 1 -C 10 alkyl-NH—C 1 -C 10 alkyl), —NRbC(O)ORc, —NRbC(O)NRcRd, —NRbC(O)NH 2 , —NRbS(O) 2 Rc, —NO 2 , —C(O)Rd, —COORd, and —OC(O)Rd, wherein, Rb, Rc and Rd are independently selected from the group consisting of hydrogen, —C 1 -C 10 alkyl, —C 3 -C 10 cycloalkyl, aryl, and heterocycle; and wherein any —C 3 -C 10 cycloalkyl, aryl, or heterocycle is independently unsubstituted or substituted with 1-4 substituents selected from the group consisting of halogen, NH 2 , N(CH 2 ) 2 , —C 3 -C 10 cycloalkyl, hetrocycle, —COORd, —OH, —O—C 1 -C 10 alkyl and —C 1 -C 10 alkyl; and wherein any —C 1 -C 10 alkyl or —OC 1 -C 10 alkyl is independently unsubstituted or substituted with 1-4 substituents selected from the group consisting of halogen, —OH, —COORd, —C 3 -C 10 cycloalkyl and aryl; and wherein n and m are each independently 1.