Patent ID: 7375075

Claim:
An isolated polypeptide consisting of: (i) a Drosophila Legless (dLgs) protein consisting of amino acids 1 to 1464 of SEQ ID NO:23, or (ii) a peptide fragment of (i), wherein said fragment has the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4 and inhibits tcf-driven luciferase activity in colon cancer cells, or (iii) a peptide fragment of (i) having at least 90% amino acid sequence identity to the amino acid sequence of SEQ ID NO:4 and inhibits tcf-driven luciferase activity in colon cancer cells, or (iv) a peptide having at least 90% amino acid sequence identity to the amino acid sequence of SEQ ID NO:5 and inhibits tcf-driven luciferase activity in colon cancer cells, or (v) a peptide fragment of (i) having at least 90% amino acid sequence identity to the amino acid sequence of SEQ ID NO:2 and inhibits tcf-driven luciferase activity in colon cancer cells, or (vi) a peptide fragment of (i) having at least 90% amino acid sequence identity to the amino acid sequence of SEQ ID NO:3 and inhibits tcf-driven luciferase activity in colon cancer cells.