Patent ID: 8521259

Claim:
A method comprising: positioning a distal portion of a delivery device at a location in a blood vessel the distal portion of the delivery device comprising a balloon and a delivery lumen coupled to an exterior surface of the balloon; imaging a thickness of at least a portion of a wall of the blood vessel at the location with an imaging assembly disposed in a second lumen of the delivery device; identifying a treatment site beyond an external elastic lamina of the blood vessel based on the imaging; inflating the balloon to cause a portion of the delivery lumen to pivot from a first position toward a direction of the wall of the blood vessel; after inflating the balloon to pivot the delivery lumen, advancing a needle beyond the delivery lumen of the delivery device a distance into the wall of the blood vessel to the treatment site beyond the external elastic lamina of the blood vessel; and after advancing the needle, introducing a treatment agent in a sustained release composition through the needle.