Patent ID: 7595402

Claim:
A prodrug of a selective androgen receptor modulator (SARM) compound, wherein said prodrug is represented by a structure of formula II-B: wherein X is a bond, O, CH 2 , NH, Se, PR, NO or NR; Z is NO 2 , CN, COOH, COR, NHCOR or CONHR; Y is CF 3 , F, I, Br, Cl, CN, C(R) 3 or Sn(R) 3 ; Q is alkyl, F, I, Br, Cl, CF 3 , CN, C(R) 3 , Sn(R) 3 , N(R) 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH 3 , NHCSCF 3 , NHCSR, NHSO 2 CH 3 , NHSO 2 R, OR, COR, OCOR, OSO 2 R, SO 2 R, SR, SCN, NCS, OCN, or NCO; R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, F, I, Br, Cl, alkenyl or OH; and R 1 is one of the stuctures: and wherein R 5 , R 6 , and R 9 are independently of each other a hydrogen, alkyl, F, I, Br, Cl, CF 3 , CN, CR 3 , Sn(R) 3 , N(R) 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH 3 , NHCSCF 3 , NHCSR NHSO 2 CH 3 , NHSO 2 R, OR, COR, OCOR, OSO 2 R, SO 2 R, SR, SCN, NCS, OCN, NCO, wherein Q 3 and Q 4 are independently of each other a hydrogen, alkyl, F, I, Br, Cl, CF 3 , CN, C(R) 3 , Sn(R) 3 , N(R) 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH 3 , NHCSCF 3 , NHCSR NHSO 2 CH 3 , NHSO 2 R, OR, COR, OCOR, OSO 2 R, SO 2 R or SR, SCN, NCS, OCN, or NCO.