Patent ID: 6858205

Claim:
A method of administering gene therapy or delivering recombinant or foreign polynucleotides to mammalian cells or organisms, comprising the steps of: a) creating a genetically engineered baculovirus having a deletion, inactivation or downregulation of an envelope protein gene of a progenitor baculovirus, from which said engineered baculovirus is derived, wherein said genetically engineered virus is supplied, in trans or cis, with a heterologous envelope protein or a protein or other molecule that facilitates entry of said engineered baculovirus into a cell that is not normally a host of said progenitor baculovirus; b) further modifying said engineered baculovirus to express a gene therapy agent or recombinant or foreign polynucleotide; and c) delivering said modified baculovirus into said mammalian cell or organism.