Patent ID: 7407772

Claim:
A method for appropriately selecting a statin and a non-statin drug for co-administration to a patient in need of such co-administered drug treatment to avoid or minimize an increase in the plasma levels of the open-acid form of the statin, wherein the open-acid form of the statin is susceptible to human metabolic glucuronidation to form an acyl glucuronide conjugate by a human uridine 5′-diphosphate-glucuronosyltransferase (UGT) isozyme, comprising: (a) testing the statin in a human UGT-specific glucuronidation assay to identify which one or more UGT isozymes are responsible for glucuronidation of the open-acid form of the statin to form an acyl glucuronide conjugate, and (b) selecting the non-statin as appropriate for co-administration with the statin if: (i) the non-statin is not metabolically glucuronidated as determined by testing the non-statin in a glucuronidation assay, or (ii) the non-statin is not metabolically glucuronidated by any of the one or more UGT isozymes identified in step (a) as determined by testing the non-statin in the UGT-specific glucuronidation assay.