Patent ID: 7186810

Claim:
A composition of matter of the formula (X 1 ) a —F 1 —(X 2 ) b and multimers thereof, wherein: F 1 is an Fc domain; X 1 and X 2 are each independently selected from -(L 1 ) c -P 1 , -(L 1 ) c -P 1 -(L 2 ) d -P 2 , -(L 1 ) c -P 1 -(L 2 ) d -P 2 -(L 3 ) e -P 3 , and -(L 1 ) c -P 1 -(L 2 ) d -P 2 -(L 3 ) e -P 3 -(L 4 ) f -P 4 P 1 , P 2 , P 3 , and P 4 are each independently randomized TNF-α binding peptide sequences; L 1 , L 2 , L 3 , and L 4 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1 and wherein “peptide” refers to molecules 2 to 40 amino acid and wherein neither X 1 nor X 2 is a native protein.