Patent ID: 7872101

Claim:
A method for identifying a modulator of the G protein-coupled receptor 78 (GPR78) or G protein-coupled receptor 26 (GPR26) polypeptide, comprising: a) contacting the GPR78 or GPR26 polypeptide or a fragment thereof with a ligand of the GPR78 or GPR26 polypeptide in the presence and absence of a test sample, wherein the GPR78 or GPR26 ligand is selected from the group consisting of: isoflavone or an analog thereof, genistein or an analog thereof and daidzein or an analog of thereof; and b) measuring the activity of the GPR78 or GPR26 polypeptide, wherein a modulator of the GPR78 or GPR26 polypeptide in the test sample is identified by measuring a change in the activity of the GPR78 or GPR26 polypeptide in the presence and absence of the test sample.