Patent ID: 7364847

Claim:
A method for screening an inhibitor for binding between exon 5 of presenilin-2 gene and high mobility group box 1 (HMG-I) protein, comprising: detecting the presence or absence of a substance to be tested, a binding between HMG-I protein and a nucleic acid capable of binding to HMG-I protein wherein said nucleic acid consists of the sequence of SEQ ID NO: 4, or determining a binding strength of the binding, wherein the following I) or II): I) the binding between the nucleic acid and the HMG-I protein is not detected in the presence of the substance to be tested, or II) a binding strength of binding between the nucleic acid and the HMG-I protein in the presence of the substance to be tested is smaller than a binding strength of binding between the nucleic acid and the HMG-I protein in the absence of the substance to be tested Is used as an index, thereby showing that the substance to be tested is an inhibitor for binding between exon 5 of presenilin-2 gene and HMG-I protein.