Patent ID: 8138181

Claim:
A compound of general Formula I: or a pharmaceutically acceptable salt thereof, wherein: A is —Z—(CH 2 ) p -(hetCyc 2a ), —Z-(hetCyc 2b ), Z—R 10 or Z—R 11 ; Z is O or NH; p is 0, 1, or 2; hetCyc 2a is a 5 or 6 membered heterocyclic ring optionally substituted with one or more R 9 groups; hetCyc 2b is a 7-12 membered spirocyclic or bridged heterobicyclic ring system optionally substituted with one or more R 9 groups; R 10 is (1-6C)alkyl substituted with NR′R″; R 11 is (5-6C)cycloalkyl substituted with NR′R″; B is H, CN, OR h , Ar 1 , hetAr 2 , C(O)NR i R j , C(O)-hetCyc 3 , C(O)NH(1-6C alkyl)-hetCyc 3 , C(O)(1-6C alkyl)-hetCyc 3 , SR k , SO 2 N(1-6C alkyl) 2 , (1-6C alkyl)NR′R″ or (1-3C)alkyl; R 1 , R 2 , R 3 and R 4 are independently H, F, Cl, CN, Me, Et, isopropyl, cyclopropyl, C(O)NR′R″, CH 2 OH, or hetAr 3 ; R 1a is H, F, Cl, or Me; R 5 , R 6 , R 7 and R 8 are independently H, F, Cl, CN or Me; each R 9 is independently selected from halogen, CN, CF 3 , (1-6C)alkyl, NR a R b , -(1-6C alkyl)NR a R c , OR a , (1-6C alkyl)OR a [optionally substituted with amino], C(O)NR a R c , C(O)(CR x R y )NR a R c , NHC(O)R e , NHC(O)(CR m R n )NR a R c , NHC(O)NR f R g , (1-6C alkyl)-hetAr 1 , (1-6C alkyl)-hetCyc 1 , oxo, and C(O)O(1-6C alkyl); each R a is independently H or (1-6C)alkyl; each R b is independently H, (1-6C)alkyl, (1-6C alkyl)OH, (3-6C)cycloalkyl, CH 2 hetAr 4 , (1-6C fluoroalkyl) or -(1-6C alkyl)-O-(1-6C alkyl), each R c is independently H, (1-6C)alkyl, (3-6C)cycloalkyl, or aryl; each R e is independently (1-6C alkyl); each R f and R g is independently H or (1-6C alkyl); R h is H, CF 3 , (1-6C)alkyl, (1-6Calkyl)-(3-6C cycloalkyl), (1-6C alkyl)-O-(1-6C alkyl), (1-6C alkyl)OH, (1-6C alkyl)-S-(1-6C alkyl), (1-6C alkyl)NR′R″, hetCyc 4 ,(1-6C alkyl)hetCyc 4 , (1-6C alkyl)aryl, or (1-6C alkyl)-hetAr 5 ; R i is H or 1-6C alkyl; R j is (1-6C)alkyl, (1-6C alkyl)-O-(1-6C alkyl), or (1-6C alkyl)-OH; R k is (1-6C)alkyl, (3-6C)cycloalkyl, or (1-6C alkyl)-O-(1-6C alkyl); R m and R n are independently H or (1-6C alkyl); R x and R y are independently H or (1-6C alkyl), or R x and R y together with the atom to which they are attached form a cyclopropyl ring; Ar 1 is aryl optionally substituted with OH, O-(1-6C alkyl), C(O) 2 (1-6C alkyl), or (1-6C alkyl)NR′R″; hetCyc 1 is a 5-6 membered heterocyclic ring which is optionally substituted with (1-6C)alkyl or OH; hetCyc 3 and hetCyc 4 are independently a 5 or 6 membered heterocyclic ring optionally substituted with OH or —O(1-6C alkyl); hetAr 1 and hetAr 2 are a 5-6 membered heteroaryl ring optionally substituted with one to three groups independently selected from (1-6C)alkyl, (3-6C)cycloalkyl, halogen, CN, CF 3 , OCH 2 F, OCF 3 , O(1-6C alkyl), O(3-6C)cycloalkyl, and NR′R″; hetAr 3 and hetAr 4 are independently a 5-6 membered heteroaryl ring; hetAr 5 is a 5-6 membered heteroaryl ring optionally substituted with (1-6C)alkyl; and R′ and R″ are independently H or (1-6C)alkyl.