Patent ID: 8536172

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: Y′ is CH or N; X is CH or N; each X 1 is independently halogen, lower alkyl, lower alkoxy, lower haloalkyl, or hydroxy; m is 0, 1, or 2; X 2 is H, lower alkyl, lower alkoxy, amido, lower haloalkyl, or lower haloalkoxy; X 3 is lower alkyl, lower alkoxy, or lower haloalkyl; p is 0 or 1; each X 4 is independently lower alkyl, lower alkoxy, lower haloalkyl, hydroxy, lower hydroxylalkyl, OC(═O)Z 2 , or halogen; X 5 is lower alkyl; s is 0, 1, or 2; q is 0, 1, or 2; r is 0 or 1; Y is H, OH, C(═O)Z 2 , C(═O)OZ 2 , OZ 2 , OC(═O)Z 2 , N(Z 1 )C(═O)(Z 2 ), C(Z 1 ) 2 S(O) 2 Z 2 , N(Z 1 )S(O) 2 Z 2 , N(Z 1 )S(O) 2 N(Z 1 )(Z 2 ), C(Z 1 ) 2 (Z 2 ), or (C═O)N(Z 1 )(Z 2 ); Z 1 is H or Z 1 ′; Z 1 ′ is lower alkyl, optionally substituted with one or more Z″; each Z″ is independently halogen, hydroxy, lower haloalkyl, dialkylamino or amino; Z 2 is H or Z 2 ′; Z 2 ′ is hydroxy, lower alkyl, lower alkoxy, lower hydroxyalkyl, lower haloalkyl, cycloalkyl, cycloalkyl lower alkyl, heterocycloalkyl, heterocycloalkyl lower alkyl, optionally substituted with one or more Z 2 ″; each Z 2 ″ is independently halogen, hydroxy, lower alkyl, cycloalkyl, cyano, lower haloalkyl, amino, carboxylic acid, ester, or lower alkoxy; R 1 is a bond, C(═O), C(═O)O, C(═O)CH 2 OC(═O), C(═O)CH 2 NHC(═O)O, or S(═O) 2 ; R 2 is H or R 2 ′; R 2 ′ is hydroxy, lower alkyl, N(R 3 ) 2 , lower hydroxyalkyl, or lower haloalkyl, optionally substituted with one or more R 2 ″; each R 2 ″ is independently cyano, amino, dialkylamino, hydroxy, lower hydroxyalkyl, or lower alkoxy; and each R 3 is independently H, lower alkyl, lower cycloalkyl, phenyl, lower heterocycloalkyl, or both R 3 together form a heterocyclic ring; with the proviso that when X is N, X 2 is H, Y′ is CH, R 1 is C(═O), R 2 is methyl, r is 1, m is 0, p is 0, q is 0, Y is N(Z 1 )S(O) 2 Z 2 , and Z 2 is methyl, then Z 1 is not H or hydroxyethyl.