Patent ID: 8450377

Claim:
A compound of the formula: wherein R 1 is Ad- or Ad-(L1)n-, wherein n is 0 or 1, Ad is adamantyl, and L1 is a linking group selected from the group consisting of C1-6 alkylene, C1-6 cycloalkylene, and C1-6 arylene; Y is H; and R 2 is CY1=CHR3, wherein Y1 is H, C1-6 alkyl, aryl, or halo; and R3 is aryl, aryl optionally substituted by X, or HET; X is hydrogen, straight chain or branched C1-6 alkyl, halo, amino, C1-6 alkyl amino, C1-6 dialkyl amino, pyrrolidinyl, piperadinyl, morpholinyl, piperazinyl, C1-6 alkoxy, C1-6 aralkoxyl, aryl, C1-6 aralkyl, nitro, cyano or a phosphorus containing group; and HET is optionally substituted pyrrolidinyl, piperadinyl, morpholinyl, piperazinyl, pyrrolyl, pyridinyl, and pyridazinyl, quinolinyl, or thiophenyl, and wherein the substitutuent is X; or a pharmaceutically acceptable salt or derivative thereof.