Patent ID: 7531695

Claim:
A compound having the structural formula A wherein: a. R 1 is selected from the group consisting of substances having formulae A 1 , A 2 , A 3 , A 4 , A 5 , and A 6 wherein: i) Z is selected from the group consisting of CH, and nitrogen, ii) Y 3 is selected from the group consisting of C 2-8 alkyl, and C 2-8 substituted alkyl, iii) R 6 is selected from the group consisting of —OH, alkyloxy, aryloxy, alkylcarboxy, arylcarboxy, —SH, alkylthio, arylthio, —NH 2 , alkylamino, arylamino, N-aryl-N-alkylamino, —NHNH 2 , alkylhydrazino, arylhydrazino, N-aryl-N-alkylhydrazino, —NHOR 17 , —O(P═O)(OR 17 )(OR 8 ), —OCH 2 O(P═O)(OR 17 )(OR 8 ), and —OSO 3 R 17 , iv) R 7 is selected from the group consisting of hydrogen, halogen, and alkyl, v) each of R 15 and R 16 is independently selected from the group consisting of —OH, alkyloxy, aryloxy, —NH 2 , alkylamino, arylamino, N-aryl-N-alkylamino, —NHNH 2 , alkylhydrazino, arylhydrazino, N-aryl-N-alkylhydrazino, —NHOR 17 , alkyl, and aryl, vi) each of R 17 and R 18 is independently selected from the group consisting of hydrogen, alkyl, and aryl, vii) ** represents the point of attachment of the R 1 to the molecule of formula A; b. R 2 is selected from the group consisting of wherein: i) each of R 8 , R 9 , R 10 and R 11 is independently selected from the group consisting of hydrogen, halogen and alkyl, ii) each of Y 1 and Y 2 is independently O, S, NH, or CH 2 , or Y 1 is O, S or NH, and Y 2 is CH 2 , with the proviso that Y 1 and Y 2 cannot both be O, S, or NH if n is 0 or 1, and iii) * represents the point of attachment of the R 2 to the molecule of formula A; c. R 3 substituents are independently selected from the group consisting of alkyl, alkyloxy, and halogen; d. R 4 is selected from the group consisting of alkyl, aryl, heteroaryl, and adamantyl; R 5 is selected from the group consisting of alkyl, alkyloxy, alkylthio, aryl, and heteroaryl; or R 4 and R 5 may be linked together to form a substituted or unsubstituted 5- or 6-membered cycloalkyl or cycloalkenyl ring, where said substituents are selected from the group consisting of —OH, ═O, halogen, alkyl, and where 1 or 2 of the carbon atoms on said 5- or 6-membered cycloalkyl or cycloalkenyl ring may be optionally replaced by W where W is selected from the group consisting of O, S, N, NH, alkylamino, and arylamino; e. each of m and n is independently 0, 1, 2 or 3, and pharmaceutically acceptable salts thereof.