Patent ID: 8802125

Claim:
A biocompatible delayed release system comprising: (i) a polycaprolactone polymer matrix, wherein the biocompatible delayed release system comprises about 30% to 90% by weight of polymer matrix, and the polymer matrix formulated as a lamellar charged structure; and (ii) an intercalation compound dispersed inside the polycaprolactone polymer matrix, wherein the intercalation compound comprises: (a) an inorganic hydrotalcyte component having a lamellar structure with a neutralized net positive or negative charge; and (b) a diclofenac intercalated within said hydrotalcvte lamellar structure and having an ionic bond with the inorganic hydrotalcyte component, wherein the intercalated combination of the inorganic hydrotalcyte component and of the diclofenac constitutes the intercalation compound, and the diclofenac is present in a quantity ranging from between about 1% to 50% by weight as compared to the inorganic hydrotalcyte component, and the concentration of the intercalation compound in the biocompatible delayed release system is between about 1% and 10%, and wherein the delayed release system has a two stage release profile.