Patent ID: 8202991

Claim:
A process for preparation of 2-fluoroadenine, the method comprising: a) reacting 2,6-diaminopurine in an amount of anhydrous fluorinating agent, the reacting performed in presence of nitrite at a temperature range between −30° C. and −10° C. to produce a reaction mixture; b) heating the reaction mixture for a time interval between 0.5 hours to 4 hours, to provide a heated reaction mixture at a temperature from −5° C. to +5° C.; c) quenching the heated reaction mixture with a first added amount of water to obtain a solid, expressed in kilograms, the added amount of water being 7 to 13 times the amount of anhydrous fluorinating agent expressed in kilograms; d) separating the solid from the heated reaction mixture; e) washing the solid 4 to 7 times with a second added amount of water to obtain a washed solid; f) further separating the washed solid in absence of further additional purification steps, and drying the separated washed solid under vacuum at a temperature of from 70° C. to 85° C., to obtain 2-fluoroadenine in a yield of from 53% to 68% with respect to the 2,6-diaminopurine, and with a purity of at least 98% (HPLC area).