Patent ID: 7902227

Claim:
A compound of formula (I) wherein R is selected from the group consisting of hydrogen and lower alkyl; R 1 is selected from the group consisting of C 3 -C 6 cycloalkyl, C 4 -C 6 heterocycloalkyl, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, phenyl and a 5 to 6 membered heteroaryl; wherein the C 3 -C 6 cycloalkyl, C 4 -C 6 heterocycloalkyl, phenyl or 5 to 6 membered heteroaryl is optionally substituted with one to four substituents independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, nitro, amino, (lower alkyl)amino and di(lower alkyl)amino; A is selected from the group consisting of CR 5 ; wherein R 5 is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, halogenated lower alkyl, lower alkoxy, halogenated lower alkoxy, C 1 -C 4 alkylthio, amino, (lower alkyl)amino, di(lower alkyl)amino and cyano; alternatively, A is CR 5 , and R 5 and R 1 are taken together with the atoms to which they are bound to form R 2 and R 3 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, amino, (lower alkyl)amino, di(lower alkyl)amino, lower alkoxy, C 1 -C 4 alkylthio, lower alkyl, C 2 -C 4 alkenyl and C 2 -C 4 alkynyl; R 4 is selected from the group consisting of C 1 -C 8 alkyl, —C(O)O-(lower alkyl), aryl, heteroaryl, heterocycloalkyl, —(C 1 -C 4 alkyl)-C 3 -C 6 cycloalkyl, —(C 1 -C 4 alkyl)-aryl, —(C 1 -C 4 alkyl)-heteroaryl, and —(C 1 -C 1-4 alkyl)-heterocycloalkyl; wherein the C 1 -C 8 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, amino, (lower alkyl)amino, di(lower alkyl)amino, aryloxy, heteroaryloxy, acyloxy, carboxy, carboxamido, acylamino, oxo, thio, and cyano; and wherein the aryl, heteroaryl or heterocycloalkyl, whether alone or as part of a substituent group, is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, oxo, cyano, mercapto, nitro, amino, (lower alkyl)amino, di(lower alkyl)amino, C 1 -C 8 -alkyl, halogenated C 1 -C 8 alkyl, C 1 -C 8 alkoxy, halogenated C 1 -C 8 alkoxy, C 1 -C 8 alkylthio, formyl, carboxy, —C(O)O-(lower alkyl), —O—C(O)—(C 1 -C 8 -alkyl), —NH—C(O)—(C 1 -C 8 -alkyl), carboxamide, a second aryl and a second heteroaryl; and wherein the second aryl or second heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, (lower alkyl)amino, di(lower alkyl)amino, C 1 -C 8 -alkyl, halogenated C 1 -C 8 alkyl, C 1 -C 8 alkoxy, halogenated C 1 -C 8 alkoxy, C 1 -C 8 alkylthio, carboxy and —C(O)O-(lower alkyl); or optical isomer, diastereomer, enantiomer, pharmaceutically acceptable salt thereof.