Patent ID: 8404736

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 are independently selected from the group consisting of: hydrogen, C 1-6 alkyl, C 1-6 cyclolkyl, C 1-6 fluorocycloalkyl, and C 1-6 fluoroalkyl; or R 1 , R 2 , together with the carbon atom to which they are both attached, complete a three- to six-membered carbocyclic ring which is optionally substituted with R c , or complete a three- to six-membered ring which contains one or two heteroatom(s) each independently selected from S, O or NR b , wherein R b is selected from the group consisting of: hydrogen, C 1-6 alkyl, C 1-6 cyclolkyl, C 1-6 fluorocycloalkyl, C 1-6 fluoroalkyl, aryl, heteroaryl, C(O)C 1-6 alkyl, C(O)aryl, S(O) 2 alkyl, and S(O) 2 aryl; Y is O or S; X is a bond, ═CH—, CH 2 , O, or S; Ar 1 and Ar 2 are independently aryl, wherein Ar 1 and Ar 2 are optionally substituted with one to three R c groups; R c is independently halo or R 1 , R a is —CO 2 H, —CO 2 M, —C(O)NHS(O) 2 R aa or R aa is C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 cycloalkyl, C 1-6 cyclohaloalkyl, aryl, or heteroaryl; M is a pharmaceutically acceptable salt or an ester prodrug group; has the structure wherein —K-L-M- is —C(R 3 )═C(R 4 )—N—, R 3 is hydrogen, and R 4 is hydrogen.