Patent ID: 8173680

Claim:
A compound of formula (I) or a salt or N-oxide thereof: wherein: X is a bond, or a divalent radical selected from —C(R 10 )(R 11 )—*, —C(R 10 )(R 11 )—O—*, —C(R 10 )(R 11 )CH 2 —*, —C(R 10 )(R 11 )CH 2 —O—*, —CH 2 C(R 10 )(R 11 )—*, —CH 2 C(R 10 )(R 11 )—O—*, and —CH 2 —O—C(R 10 )(R 11 )—*, wherein the bond indicated by an asterisk is attached to the pyrazole ring; Z is a radical selected from the group consisting of those of formulae (1)-(26) as follows: wherein R is C 1 -C 6 alkyl; phenyl or benzyl optionally ring-substituted by R 5 ; or a monocyclic non-aromatic carbocyclic ring of 3 to 6 ring atoms; R 3 is hydrogen, (C 1 -C 3 )alkyl or (C 1 -C 3 )fluoroalkyl; R 4 is a radical of formula -(Alk 1 ) p -(Q 1 ) r -(L) s -Q 2 wherein p, r and s are independently 0 or 1, provided that at least one of p, r and s is 1; Alk 1 is a divalent (C 1 -C 4 )alkylene radical which (a) is optionally substituted on one carbon by R 10 and/or R 11 or by one or two optional substituents, and/or (b) optionally contains a —O—, —S—, —CO—, —SO—, —SO 2 —, or —NR 9 — link; L is a divalent radical of formula -(Alk 2 ) n -(W) m —, in either orientation, wherein n and m are independently 0 or 1; Alk 2 is —C(R 10 )(R 11 )—; and W is —CO—, —SO 2 —, —O—, —NR 9 — or —SO—; provided that when W and/or Alk 2 are linked to a heteroatom W is not —O—, —NR 9 — or —SO—; Q 1 is a monocyclic carbocyclic ring of 3 to 6 ring atoms, a bicyclic carbocyclic ring system of 7 to 10 ring atoms, a monocyclic heterocyclic ring of 4 to 6 ring atoms or a bicyclic carbocyclic ring system of 8 to 10 ring atoms, any of which rings or ring systems being optionally substituted; Q 2 is (a) in the case where s in -(L) s -Q 2 is 0 or 1, a monocyclic carbocyclic ring of 3 to 6 ring atoms, a bicyclic carbocyclic ring system of 7 to 10 ring atoms, a monocyclic heterocyclic ring of 4 to 6 ring atoms or a bicyclic carbocyclic ring system of 8 to 10 ring atoms, any of which rings or ring systems being optionally substituted; or (b) only in the case where s in -(L) s -Q 2 is 0, hydrogen; or R 3 and R 4 taken together with the nitrogen to which they are attached form a cyclic amino ring of 4 to 7 ring atoms which is optionally substituted by a radical of formula -(L) s -Q 2 wherein s, L and Q 2 are as defined above, or by an optional substituent selected from hydroxy, methoxy, —NH 2 —, or mono- or di-(C 1 -C 3 )alkylamino; R 5 , R 6 , R 7 and R 8 are each independently selected from hydrogen —F, —Cl, —Br, —CN, (C 1 -C 3 )alkyl, (C 1 -C 3 )fluoroalkyl, cyclopropyl, and —OR 9 ; R 9 is hydrogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )fluoroalkyl, or (C 3 -C 6 )cycloalkyl; and R 10 is hydrogen, (C 1 -C 3 )alkyl, hydroxyl or NH 2 , and R 11 is hydrogen or (C 1 -C 3 )alkyl; or R 10 and R 11 taken together with the carbon atom to which they are attached form a (C 3 -C 5 )cycloalkyl ring.