Patent ID: 8153633

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein Cy 1 is a partially or fully saturated or unsaturated 3-8 membered monocyclic, or 6-12 membered bicyclic ring system, the ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, or 1-6 heteroatoms if bicyclic, and wherein each ring of the ring system is optionally substituted independently with 1-5 substituents, wherein the substituents are selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, halogen, cyano, hydroxy, oxo, —OR c , —NR a R b , NR a C(═O)R b , —C(═O)OR c , —R c OC(═O)NR a R b , —R c OH, —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and S(═O) m R c ; R 1 , R 2 , R 3 , and R 4 are each H; R 5 , R 6 , R 7 , and R 8 are each independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, oxo, —C(═O)OR a , —R c OH, —OR c , —NR a R b , NR a C(═O)R b , —C(═O)OR c , —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and S(═O) m R c , provided that at least one of R 5 , R 6 , R 7 , and R 8 is not H; R a , R b , and R c are each independently selected from H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, heterocyclyl, aryl, and heteroaryl; m is 1 or 2; L is —C(═O)—, —S(═O) m — or —CH 2 —; Cy 2 is a partially or fully saturated or unsaturated 3-8 membered monocyclic ring system, the ring system formed of carbon atoms optionally including 1-3 heteroatoms, and wherein the ring system is optionally substituted independently with 1-5 substituents, wherein the substituents are selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, halogen, cyano, hydroxy, oxo, —C(═O)OR c , —R c OH, —OR c , —NR a R b , NR a C(═O)R b , —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and S(═O) m R c .