Patent ID: 7348335

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is a phenyl, cyclohexyl, cyclopentyl, pyridyl, naphthyl, morpholino, piperazinyl, or piperidinyl ring, wherein R 1 is optionally substituted with q independent occurrences of Z-R Z ; wherein q is 0-5, Z is a bond or is a C 1 -C 6 alkylidene chain wherein up to two methylene units of Z are optionally and independently replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each occurrence of R Z is independently selected from R′, halogen, NO 2 , CN, OR′, SR′, N(R′) 2 , NR′COR′, NR′CON(R′) 2 , NR′CO 2 R′, COR′, CO 2 R′, OCOR′, CON(R′) 2 , OCON(R′) 2 , SOR′, SO 2 R′, SO 2 N(R′) 2 , NR′SO 2 R′, NR′SO 2 N(R′) 2 , COCOR′, or COCH 2 COR′; each occurrence of R is independently hydrogen or an optionally substituted C 1-6 aliphatic group; and each occurrence of R′ is independently hydrogen or an optionally substituted C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or R and R′, two occurrences of R, or two occurrences of R′, are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Z 1 is N; Z 7 is C—UR Y ; T and U are each independently a bond or a saturated or unsaturated C 1-6 alkylidene chain, wherein up to two methylene units of the chain are optionally and independently replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; R X and R Y are each independently halogen, CN, NO 2 , or R′; Z 2 , Z 5 and Z 6 are each independently N or CH, provided that no more than two of Z 2 , Z 5 , and Z 6 are N; Z 3 is CR 3 ; Z 4 is CR 4 ; wherein one of R 3 or R 4 is R U , and the other of R 3 or R 4 is R V1 , wherein: R U is (CH 2 ) t CN, (CH 2 ) t NO 2 , (CH 2 ) t N(R) 2 , (CH 2 ) t NRC(O)R, (CH 2 ) t CON(R) 2 , (CH 2 ) t COOR, (CH2) t SO 2 N(R) 2 , (CH 2 ) t NRSO 2 R, (CH 2 ) t NRCON(R) 2 , (CH 2 ) t NRSO 2 N(R) 2 , (CH 2 ) t COCOR, (CH 2 ) t Ar 2 , wherein t is 0, 1, or 2, and Ar 2 is an optionally substituted 5-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and R V1 is OR′.