Patent ID: 8821920

Claim:
A topical patch comprising a therapeutic compound-impermeable backing layer, a self-adhesive amine-resistant polysiloxane matrix consisting of: (i) a therapeutic compound for treating neuropathic pain consisting of about 5%-about 10% by weight of capsaicin or a capsaicin analog or mixture thereof as the therapeutic compound, based on the total weight of the matrix; and (ii) about 10%-about 25% by weight of diethylene glycol monoethyl ether (DGME) based on the total weight of the matrix, wherein the polysiloxane matrix is a mixture of a polysiloxane of medium tack and a polysiloxane of high tack, wherein the matrix contains from about 0.5 to about 5% by weight of a silicone oil, wherein the matrix comprises 58-85% by weight of self adhesive polysiloxane and the coating weight of the matrix is between 30 and 200 g/m 2 , and a protective film to be removed before use, in which a. the matrix contains liquid microreservoir droplets comprising an amphiphilic solvent, in which the therapeutic compound is dissolved, wherein the microreservoir droplets are in an amount between 20 and 40% by weight, based on the total weight of the matrix, wherein the microreservoir droplets comprise a viscosity-increasing additive dissolved in the solvent, and b. the concentration of the therapeutic compound in the microreservoir droplets is between 40 and 70% by weight of the saturation concentration, wherein the amphiphilic solvent is diethylene glycol monoethyl ether.