Patent ID: 8241620

Claim:
A composition comprising an amphiphilic polysaccharide-PDGF complex solubilized in an aqueous medium, wherein: the amphiphilic polysaccharide comprises a hydrophilic polysaccharide backbone functionalized with hydrophobic substituents and hydrophilic substituents according to the following general formula: R and R′ being a bond or a chain comprising between 1 and 18 carbons, optionally branched, unsaturated, and/or containing one or more heteroatoms, R and R′ being identical to or different from one another, F and F′ being selected from the group consisting of an ester, an amide, a carbamate, and an ether, F and F′ being identical to or different from one another, X being a hydrophilic group that is a carboxylate, Hy being a hydrophobic group that is selected from the group consisting of: a C 8 to C 30 linear or branched alkyl, optionally unsaturated and/or containing one or more heteroatoms, a C 8 to C 18 linear or branched alkylaryl or arylalkyl, optionally unsaturated and/or containing one or more heteroatoms, and an optionally unsaturated C 8 to C 30 polycycle, n and o are between 1 and 3, h represents the molar fraction of hydrophobic groups to saccharide units and is between 0.01 and 0.5, x represents the molar fraction of hydrophilic groups to saccharide units and is between 0 and 2.0, and the PDGF is a platelet-derived growth factor.