Patent ID: 8642777

Claim:
A process for producing a 3-alkoxy-2-amino-6-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula (I) or a salt thereof, where in the formula (I), R 1 and R 2 , which may be the same or different from each other, are selected from the group consisting of a hydrogen atom, a C 1-10 alkyl group, a C 2-10 alkenyl group, a phenyl group, a naphthyl group, a naphthyl group substituted with 1 to 7 halogen atoms, a heteroaromatic group, and a phenyl group substituted with 1 to 5 substituent groups selected from a group consisting of a halogen atom, a C 1-10 alkyl group, a C 1-10 alkoxy group, a trifluoro methyl group, a phenyl group, a hydroxy carbonyl group, an amino group, a nitro group, a cyano group, and a phenoxy group; R 1 and R 2 may bind to each other to form a cyclic structure, the process comprising: (A) converting a compound represented by the formula (II) or a salt thereof to a compound represented by the formula (III) or 20 a salt thereof, where in the formula (II), R 3 is selected from the group consisting of a C 1-6 alkoxy group, an amino group, and a hydroxyl group, where in the formula (Ill), R 4 represents —SiR 41 R 42 R 43 wherein R 41 , R 42 , and R 43 , which may be the same or different from each other, each represent a C 1-6 alkyl group; R 5 is selected from the group consisting of a C 1-6 alkoxy group, an amino group, and a hydroxyl group, (B) converting the compound represented by the formula (III) or a salt thereof to a compound represented by the formula (IV) or a salt thereof, where in the formula (IV), R 6 is selected from the group consisting of a hydrogen atom, a benzoyl group, a benzoyl group substituted with a halogen atom, and —SiR 61 R 62 R 63 wherein R 61 , R 62 , and R 63 , which may be the same or different from each other, each represent a C 1-6 alkyl group; R 7 is selected from the group consisting of a C 1-6 alkoxy group, an amino group, and a hydroxyl group, (C) converting the compound represented by the formula (IV) or a salt thereof to a compound represented by the formula (V) or a salt thereof, where in the formula (V), R 1 and R 2 are as defined above and R 8 is selected from the group consisting of a C 1-6 alkoxy group, an amino group, and a hydroxyl group, (D) converting the compound represented by the formula (V) or a salt thereof to a compound represented by the formula (VI) or a salt thereof, where in the formula (VI), R 1 and R 2 are as defined above and R 9 is selected from the group consisting of a C 1-6 alkoxy group, an amino group, and a hydroxyl group, and (E) converting the compound represented by the formula (VI) or a salt thereof to the compound represented by the formula (I) or a salt thereof.