Patent ID: 8586715

Claim:
A humanized anti-CD4 antibody, wherein the humanized anti-CD4 antibody comprises a sequence comprising the complementarity-determining regions (CDRs) of SEQ ID NOs: 10 and 9, displayed in FIGS. 3 and 4 , and wherein the humanized anti-CD4 antibody is capable of activating CD4 + CD25 + regulatory T cells such that the activated CD4 + CD25 + regulatory T cells are able to suppress CD4 + CD45RA+CD25−T cell proliferation in vitro in an allogenic mixed lymphocyte reaction in which the activated CD4 + CD25 + regulatory T cells are cocultured with allogenic CD4 + CD45RA+CD25−T cell in the presence of CD2-depleted peripheral blood mononuclear cells that are syngenic for the CD4 + CD25 + regulatory T cells.