Patent ID: 7223757

Claim:
A compound according to formula I its enantiomers, diastereomers, pharmaceutically acceptable salts, hydrates, prodrugs and solvates thereof; wherein X is selected from the group consisting of C, C 1 –C 3 alkyl, C 1 –C 3 alkyl substituted with one or more R 7 , and a direct bond; Y is O or S; W is N; R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each independently selected from the group consisting of H, C 1-6 alkyl, alkenyl, alkynyl, cycloalkyl, halo, amino, —OR 60 , —NO 2 , —OH, —SR 60 , —NR 60 R 61 , —CN, —CO 2 R 60 , —CONR 60 R 61 , —NR 62 CONR 60 R 61 , —NR 60 SO 2 R 61 , —SO 2 NR 60 R 61 , —SO 2 R 63 , —C(NR 62 )NR 60 R 61 , aryl, —(CH 2 ) n OR 60 , —(CH 2 ) n NR 60 R 61 , —(CH 2 ) n SR 60 , —(CH 2 ) n aryl, n is 1 to 3; R 3 is piperazinyl or substituted piperazinyl; R 60 , R 61 , R 62 , and R 63 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, hydroxy, alkoxy, aryl, and alkyl-R 25 ; R 25 is hydrogen, alkenyl, hydroxy, thiol, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, cyano, halo, sulfoxy, sulfonyl, —NR 30 COOR 31 , —NR 30 C(O)R 31 , —NR 30 SO 2 R 31 , —C(O)NR 30 R 31 ; and R 30 and R 31 are, independently, hydrogen, alkyl, or cycloalkyl.