Patent ID: 8410069

Claim:
A double-stranded RNA compound having the structure: 5′ (N) x -Z 3′ (antisense strand) 3′ Z′-(N′) y 5′ (sense strand) wherein each N and N′ is a ribonucleotide which may independently be modified or unmodified in its sugar residue; wherein each of (N) x and (N′) y is an oligomer in which each consecutive N or N′ is joined to the next N or N′ by a covalent bond; wherein each of x and y is an integer between 19 and 40; wherein each of Z and Z′ may be present or absent, but if present is 1-5 consecutive nucleotides covalently attached at the 3′ terminus of the strand in which it is present; and wherein the sequences of (N) x and (N′) y are complementary and the sequence of (N) x comprises SEQ ID NO. 622 and the sequence of (N′) y comprises SEQ ID NO:119.