Patent ID: 8017640

Claim:
A method of inhibiting the growth of tumor cells expressing a cytochrome P450 enzyme comprising contacting the tumor cells with: in which X is H; Y is selected from the group consisting of —OCOOR 17 , —OCONHR 18 , Cl , Br, I, and —OSOOR 19 in which R 17 , R 18 and R 19 are selected from the group consisting of C 1-4 alkyl, optionally substituted phenyl, C 7-12 -aralkyl and optionally substituted heteroaryl; R 1 is —Ar; R 2 , R 3 , R 4 , R 5 and R 6 are each independently selected from the group consisting of H, C 1-4 alkyl, —OH, C 1-4 alkoxy, —CN, Cl, Br, I, —NO 2 , —NH 2 , —NHR 16 , —NR 16 2 , —N + R 16 3 , —NHCOR 8 , —COOH, —CONHR 9 , —NHCOOR 9 and —COOR 9 ; R 8 and R 9 are independently selected from the group consisting of C 1-4 alkyl, optionally substituted phenyl, C 7-12 -aralkyl, optionally substituted heteroaryl and a ligand; Ar is selected from the group consisting of: in which B is N or CR 10 ; R 10 is selected from the group consisting of OH, C 1-4 alkoxy, C 1-4 alkyl, —NO 2 , —NH 2 , —CN, Cl, Br, I, —NHCOR 14 , —COON, —CONHR 15 , —NHCOOR 15 , —COOR 15 and H; Z is selected from the group consisting of O, S, —CH═CH—and NH; the or each R 11 is selected from the group consisting of OH, C 1-4 alkoxy, C 1-4 alkyl, —NO 2 , —NH 2 , —NHR 16 , —NR 16 2 , —N + R 16 3 , —CN, Cl, Br, I, —NHCOR 14 , —COOH, —CONHR 15 —NHCOOR 15 and COOR 15 ; n is an integer in the range 0 to 4; R 12 is selected from the group consisting of H, —COAr 1 , —CONH 2 , —COOH, —COR 15 or —COOR 15 ; the or each R 13 is selected from the group consisting of OH, C 1-4 alkoxy, C 1-4 alkyl, —NO 2 , —NH 2 , —NHR 16 , —NR 16 2 , —N + R 16 3 , —CN, Cl, Br, I, —NHCOR 14 , —COOH, —CONHR 15 , —NHCOOR 15 and —COOR 15 ; m is 0, 1 or 2; R 14 is selected from the group consisting of C 1-4 alkyl, optionally substituted phenyl, optionally substituted heteroaryl, C 7-12 aralkyl, Ar 1 and a ligand; R 15 is selected from the group consisting of C 1-4 alkyl, optionally substituted phenyl, C 7-12 -aralkyl and optionally substituted heteroaryl and a ligand; the or each R 16 is independently selected from the group consisting of C 1-4 alkyl, optionally substituted phenyl, C 7-12 -aralkyl and optionally substituted heteroaryl; and Ar 1 is selected from the same groups as Ar; provided that no more than one group R 11 or R 13 in any one ring includes a group Ar 1 .