Patent ID: 7173031

Claim:
A compound having Formula I or II: or a pharmaceutically acceptable salt thereof, wherein: R 1 is H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; each R 2 is independently, H, halogen, cyano, NO 2 , OR 5 , NR 6 R 7 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo, aryalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; B is O, NR 8 , S, SO, SO 2 , CR 9 R 10 ; V is NR 11 or â€”(CR 47 R 48 ) p â€”; W or X are independently C or N; Y is O, S, or NR 12 ; Z is â€”CR 13 R 14 â€”, â€”(CR 13 R 14 ) m NR 15 â€”; 1 is 0 to 4; m is 0 to 2; n is 0 to 4; p is 0 to 4; R 3 , R 5 , R 6 , R 7 , R 8 , R 11 and R 15 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl; R 4 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl; R 9 and R 10 are independently H, halogen, hydroxyl, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl; R 12 is H, alkyl, substituted alkyl, CN, NO 2 or SO 2 NH 2 R 13 , R 14 , R 15 , R 47 and R 48 are independently H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, substituted heterocyclo or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms; A is: wherein R 16 and R 17 , are independently H, halogen, NO 2 , cyano, OR 26 , NR 27 R 28 , CO 2 R 29 , C(O)NR 30 R 31 , SO 2 R 32 , SO 2 NR 33 R 34 , NR 35 SO 2 R 36 , NR 37 C(O)R 38 , NR 39 CO 2 R 40 , â€”CO(CH 2 ) 1 R 41 , â€”CONH(CH 2 ) 1 R 42 , â€”OCONH(CH 2 ) 1 R 42 , O-alkylaminoalkyl, alkylaminoalkynyl, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 7 cycloalkyl, substituted C 3 to C 7 cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; R 18 and R 60 are H; R 26 , R 27 , R 28 , R 29 , R 30 , R 31 , R 32 , R 33 , R 34 , R 35 , R 36 , R 37 , R 38 , R 39 , R 40 , R 41 , and R 42 are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl.