Patent ID: 6878725

Claim:
A serine protease inhibitor compound of formula (I) wherein: R 2 is a 5 or 6 membered aromatic carbon ring optionally interrupted by a nitrogen, oxygen or sulphur ring atom, optionally being substituted in the 3 and/or 4 position (in relation to the point of attachment of X—X) by halo, nitro, thiol, haloalkoxy, hydrazido, alkylhydrazido, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, MeSO 2 — or R 1 , or the substituents at the 3 and 4 positions taken together form a fused ring which is a 5 or 6 membered carbocyclic or heterocyclic ring optionally substituted by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkyithio, alkenyl, alkynyl or R ij , and optionally substituted in the position alpha to the X—X group (i.e. 6 position for a six membered aromatic ring etc) by amino, hydroxy, halo, alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, alkoxy or alkylthio with the proviso that R 2 cannot be aminoisoquinolyl; each X independantly is a C, N, O or S atom or a CO, CR 1a , C(R 1a ) 2 or NR 1a group, at least one X being C, CO, CR 1a or C(R 1a ) 2 ; each R 1a independently represents hydrogen, hydroxyl, alkoxy, alkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkylaminocarbonyl, alkoxycarbonylamino, acyloxymethoxycarbonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl; R 1 is as defined for R 1a , provided that R 1 is not unsubstituted aminoalkyl; Y (the α-atom) is a nitrogen atom or a CR 1b group; Cy is a saturated or unsaturated, mono or poly cyclic, homo or heterocyclic group, optionally substituted by groups R 3a or R 3i X i ; each R 3a independently is R 1c , amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl, triazolyl, imidazolyl, tetrazolyl, hydrazido, alkylimdazolyl, thiazolyl, alkylthiazolyl, alkyloxazolyl, oxazolyl, alkylsulphonamido, alkylaminosulphonyl, aminosulphonyl, haloalkoxy, haloalkyl,a group of the formula —C(X 3 )N(R 11 )R 12 (wherein X 3 is O or S; and R 11 an R 12 are independantly selected from hydrogen, methyl or ethyl or together with the nitrogen atom to which they are attached form a pyrrolidin-1-yl, piperdin-1-yl or morpholino group), or —OCH 2 O— which is bonded to two adjacent ring atoms in Cy; X 1 is a bond, O, Nh or CH 2 ; R 3i is phenyl, pyridyl or pyrimidinyl optionally substtuted by R 3a ; and R 1b , R 1c and R 1j are as defined for R 1a , L is CO; and -Lp(D) n is of the formula: wherein: q is 2; Q is —O— or —NH—; and R q is R c which is pyridyl, pyrimidin-4-yl, pyridazin-3-yl, pyridazin-4-yl or phenyl (which phenyl or pyridyl group may bear a fluoro, chloro, alkyl, CONH 2 , SO 2 NH 2 , dialkylaminosulphonyl, methoxy, methylthio, alkylsulphonyl, alkylaminosulphonyl, alkylaminocarbonyl, amino, alkoxycarbonyl, acetylamino, cyano, ethoxy, nitro, hydroxy, alkylsulphonylamino, triazolyl or tetrazolyl substituent); or a physiologically-tolerable salt thereof.