Patent ID: 7052904

Claim:
An adenoviral vector, comprising: a 5′ retroviral LTR nucleic acid sequence, wherein the 5′ retroviral LTR nucleic acid sequence comprises a U3, R, U5 nucleic acid sequence and a portion of a nucleic acid sequence encoding a retroviral envelope polypeptide, a 3′ retroviral LTR nucleic acid sequence, wherein the 3′ retroviral LTR comprises an U3, R, U5 nucleic acid sequence and a portion of a nucleic acid sequence encoding a retroviral envelope polypeptide, wherein the 5′ and 3′ retroviral LTR nucleic acid sequences are Moloney Leukemia Virus LTR nucleic acid sequences, a nucleic acid sequence encoding a transgene located between the 5′ LTR and the 3′ LTR, and a retroviral packaging sequence, wherein the 5′ retroviral LTR, the 3′ retroviral LTR, the transgene and the retroviral packaging sequence are inserted into a replication-defective adenoviral vector nucleic acid sequence, and wherein the vector does not comprise a nucleic acid sequence encoding a functional retroviral gag or a functional retroviral pol, or both.