Patent ID: 7662773

Claim:
A natriuretic compound conjugate comprising: (a) a biologically active natriuretic compound comprising: (i) a natriuretic molecule NPR-A binding site; and (ii) at least one modifying moiety conjugation site wherein the biologically active natriuretic compound is a brain natriuretic peptide, atrial natriuretic peptide, C-type natriuretic peptide, dendroaspis natriuretic peptide or a biologically active segment thereof; and (b) a modifying moiety attached to said modifying moiety conjugation site, wherein the modifying moiety has a formula: each C is independently selected and is an alkyl moiety having m carbons and m is from 1 to 20; and each PAG is independently selected and is a polyalkylene glycol moiety having n subunits and n is from 2 to 25; each X is independently selected and is a linking moiety selected from the group consisting of —C—, —O—, —C(O)—, —NH—, —NHC(O)—, and —C(O)NH—, and o is from 1 to 15, and wherein said natriuretic compound conjugate exhibits one or more advantages selected from the group consisting of increased resistance to enzymatic degradation relative to a corresponding unconjugated natriuretic compound, increased circulating half life, increased bioavailability, and prolonged duration of effect.