Patent ID: 7122207

Claim:
A pharmaceutical composition comprising a core in the form of a beadlet, an enteric coating for said core, and an anti-adherent coating disposed on the exterior of said enteric coating, said core comprising about 80% to about 100% by weight of an acid labile medicament which is 2′,3′-dideoxyinosine, about 0% to about 10% by weight of a disintegrant, and about 0% to about 10% by weight of a binder selected from the group consisting of sodium carboxymethyl cellulose, hydroxypropylmethyl celiulose, potassium alginate, sodium alginate and partially pregelatinized corn starch, said composition being devoid of a protective coat or subcoat between the core and the enteric coating, wherein the weight ratio of enteric coating to core is between about 0.0:5:1 to about 0.6:1, and wherein the enteric coating should provide protection of the medicament at a pH less than 3 but will permit drug release at a pH of 4.5 or higher, said enteric coating comprising a polymer which is selected from the group consisting of polyvinyl acetate phthalate, cellulose acetate phthalate and a methacrylic acid copolymer.