Patent ID: 8414898

Claim:
A method of delivering a cytotoxic agent, a therapeutic agent or a diagnostic agent to a cell that expresses a STEAP-1 protein (SEQ ID NO:2), comprising providing a cytotoxic agent, a therapeutic agent or a diagnostic agent conjugated to an antibody or antibody fragment that (a) specifically binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:2; (b) binds to an extracellular domain of the polypeptide of SEQ ID NO:2; (c) binds to a peptide selected from SEQ ID NO:19, SEQ ID NO:20, and SEQ ID NO:21; (d) binds to a cell surface epitope of the polypeptide of SEQ ID NO:2 on NIH3T3 cells expressing the polypeptide; or (e) immunohistochemically stains 293T cells transfected with an expression plasmid encoding and expressing a polypeptide having the amino acid sequence of SEQ ID NO:2 and does not immunohistochemically stain untransfected 293T cells, wherein the antibody or antibody fragment of (a)-(e) binds to the STEAP-1 protein (SEQ ID NO: 2), to form an antibody-agent or antibody fragment-agent conjugate; and exposing the cell to the antibody-agent or antibody fragment-agent conjugate.