Patent ID: 8703727

Claim:
A method of making one or more spheres having a diameter of about 50 to 500 nanometers having a shell comprising at least one of the polymers selected from poly (D,L-lactide-coglycolide polymer) and polycaprolactone containing a poorly soluble drug selected from the group consisting of indole hydrazinecarbothioamide; fenretinide; safingol; 17-allylamino demethoxygeldanamycin and an aminoflavone drug [NSC 686288] and poorly soluble derivatives of such compounds; said method comprising the steps of forming a mixture of at least one of the polymers selected from poly (D,L-lactide-coglycolide polymer) and polycaprolactone containing a poorly soluble drug in supercritical, critical or near critical fluid selected from the compounds nitrogen, carbon dioxide, propane, nitrous oxide and fluorinated hydrocarbons, injecting said mixture in a stream in a solution comprising a cross-linking agent in a buffer to form one of more spheres having a diameter of 50 to 500 nanometers or forming a mixture of at least one of the polymers selected from poly (D,L-lactide-coglycolide polymer) and polycaprolactone in supercritical, critical or near critical fluid selected from the compounds nitrogen, carbon dioxide, propane, nitrous oxide and fluorinated hydrocarbons, injecting said mixture in a stream in a solution containing a poorly soluble drug comprising a cross-linking agent in a buffer to form one of more spheres having a diameter of 50 to 500 nanometers having a shell comprising at least one of the polymers selected from poly (D,L-lactide-coglycolide polymer) and polycaprolactone containing a poorly soluble drug.