Patent ID: 7358263

Claim:
A method of treating a condition or disorder affecting or cognition in a mammal in need thereof, wherein the condition or disorder is attention-deficit hyperactivity disorder, bipolar disorder, depression, mild cognitive impairment, migraine, mood and attention alteration, obsessive compulsive disorder, seizure, and wakefulness, comprising administering an effective amount of a compound of the formula: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein: X is S Y, and Y′ are each independently CH or CF; Z is N; one of R 1 and R 2 is heteroaryl or heterocycle; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halo, cyano, and thioalkoxy; R 3 is absent; R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the structure (a): R 7 , R 8 , R 9 , and R 10 are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl; R 11 and R 12 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro; R 13 and R 14 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, and fluoro; L is —[C(R 15 )(R 16 )] n —; R 15 and R 16 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro; m is 1; and n is an integer from 2-3.