Patent ID: 7750186

Claim:
A method for the manufacture of a biphenyl amine of the general Formula (I) where R 1 stands for hydrogen, fluorine, chlorine, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio or C 1 -C 4 -halogenalkyl, X 1 stands for fluorine, chlorine or bromine, X 2 stands for fluorine, chlorine or bromine, comprising, (1) reacting an anilide of Formula (II) with 2-methylbut-3-yn-2-ol of Formula (III) to obtain an alkynyl anilide of Formula (IV) where Hal stands for chlorine, bromine or iodine, R 2 stands for hydrogen, C 1 -C 4 -alkyl or C 1 -C 4 -alkoxy, and R 1 stands for hydrogen, fluorine, chlorine, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio or C 1 -C 4 -halogenalkyl, where R 1 and R 2 have the meanings specified above, (2) removing an acetone molecule from said alkynyl anilide of Formula (IV) in the presence of a base to form an ethynyl anilide of Formula (V) where R 1 and R 2 have the meanings specified above, (3) reacting said ethynyl anilide of Formula (V) with an thiophene dioxide of Formula (VI) to obtain a biphenyl amide of Formula (VII) where X 1 and X 2 have the meanings specified above, where R 1 , R 2 , X 1 and X 2 have the meanings specified above, and (4) removing the [—C(═O)R 2 ] protective group from said biphenyl amide of Formula (VII).