Patent ID: 7420083

Claim:
A compound of the formula: or a pharmaceutically acceptable salt or ester form thereof wherein: R 1 is a direct bond to A, unsubstituted straight-chain C 1 -C 4 alkylene, or —O—C 1 -C 4 alkylene; R 2 and R 3 are, independently hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OH, —NH 2 , —NO 2 , —O(CH 2 ) p -aryl, —O(CH 2 ) p -heteroaryl, aryl, heteroaryl, —NH(CH 2 ) p -aryl, —NH(CH 2 ) p -heteroaryl, —NH(CO)-aryl, —NH(CO)-heteroaryl, —O(CO)-aryl, —O(CO)-heteroaryl, —NH(CO)—CH═CH-aryl, or —NH(CO)—CH═CH-heteroaryl; p is an integer from 0-6; R 4 is hydrogen, C 1 -C 8 alkyl, or C 3 -C 6 cycloalkyl; A is COOH or an acid mimic; X is C 1 -C 8 alkylene, C 3 -C 6 cycloalkylene, —(CH 2 ) m O—, or —(CH 2 ) m NH—; m is an integer from 1-6; R 5 and R 6 , are, independently, hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 perfluoroalkyl, —O—C 1 -C 6 perfluoroalkyl, C 1 -C 6 alkoxy, —OH, —NH 2 , —NO 2 , —O(CH 2 ) n -aryl, —O(CH 2 ) n -heteroaryl, aryl, or heteroaryl; and n is an integer from 0-6, wherein C 1 -C 4 alkylene, —O—C 1 -C 4 alkylene, alkyl, aryl and heteroaryl are each optionally substituted by one or more substituents.