Patent ID: 8309730

Claim:
A compound of formula (I): or enantiomers, diastereomers, or pharmaceutically-acceptable salts thereof, wherein: is a single bond or double bond; one of A and D is —N— and the other of A and D is —C—; R 1 is hydrogen, C 1-3 alkyl, C 2-3 alkenyl, C 2-3 alkynyl, cyclopropyl, halogen, —CH 2 F, CHF 2 , —CF 3 , —CN, C 1-3 alkoxy, —NR d R e , —C(O)OR d , or —C(O)NR d R e ; R 2 is hydrogen or C 1-3 alkyl; R 3 is hydrogen, OH, F, Cl, or C 1-3 alkyl; R 4 is i) hydrogen, ii) C 1-3 alkyl optionally substituted with OH, F, or phenyl, iii) C 2-4 alkenyl or C 2-4 alkynyl, iv) aryl or aryl substituted with one or more of halogen, C 1-3 alkyl, methoxy, and/or —CN, v) —CR a R b R c , —C(O)R c , —(CH 2 ) p C(O)NHR c , —(CH 2 ) p NHR c , —(CH 2 ) p NHC(O)OR c , or —(CH 2 ) p NHC(O)NHR c , wherein p is zero, 1, 2, or 3, vi) —CR a R b R c wherein R b and R c together with the carbon atom to which they are attached form a 1- or 2-ring heterocycle having at least one heteroatom selected from N, O, and S, or R 3 and R 4 together with the carbon atom to which they are attached, form a 5- to 7-membered saturated heterocyclic ring having 1 to 2 heteroatoms independently selected from N, O, and S, or vii) each R 5 is independently C 1-4 alkyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 2-4 alkenyl, C 2-4 alkynyl, F, Cl, —CN, C 1-3 alkoxy, and/or —OCF 3 ; R 6 is hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 2-4 alkenyl, C 2-4 alkynyl, F, Cl, —CN, C 1-3 alkoxy, or —OCF 3 ; R 7 is aryl or heterocyclo optionally substituted with one or more of C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, CN, and/or halogen; R a is hydrogen, C 1-3 alkyl, or C 1-3 alkyl substituted with OH or F; R b is hydrogen, OH, C 1-3 alkyl, C 1-3 alkoxy, or C 1-3 alkyl substituted with OH or F; R c is: i) C 1-5 alkyl optionally substituted with OH, aryl, or haloaryl, ii) C 1-3 haloalkyl, C 3-6 cycloalkyl, or C 2-4 alkenyl, iii) C 2-4 alkynyl optionally substituted with aryl, iv) aryl optionally substituted with one or more of halogen, methoxy, —S(O)(C 1-3 alkyl), —S(O) 2 (C 1-3 alkyl), —CN, C 1-3 alkyl, C 1-3 hydroxyalkyl, C 1-3 haloalkyl, saturated heterocyclo, and/or —S—(C 1-3 alkyl), v) 1- or 2-ring aryl or heteroaryl optionally substituted with one or more of C 1-4 -alkyl, halogen, —C(O)OH, —C(O)O(C 1-3 alkyl), —C(O)NH(C 1-3 alkyl), or —C(O)N(C 1-3 alkyl) 2 , or vi) tetrahydropyranyl; R d is hydrogen or C 1-3 alkyl; R c is hydrogen or C 1-3 alkyl; and q is zero, 1, 2, or 3.