Patent ID: 8524913

Claim:
A process of producing a α-trifluoromethyl-β-substituted-β-amino acid represented by formula [4] comprising: allowing a α-trifluoromethyl-β-substituted-α,β-unsaturated ester represented by formula [1] to react with a hydroxylamine represented by formula [2] H 2 N—OH [2] to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester into a dehydrogenated closed-ring body of the α-trifluoromethyl-β-substituted-β-amino acid represented by formula [3] to react with a hydroxylamine represented by formula [2] H 2 N—OH [2] to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester into a dehydrogenated closed-ring body of the α-trifluoromethyl-β-substituted-β-amino acid represented by formula [6] and hydrogenolyzing the dehydrogenated closed-ring body, wherein, in the formulae, R 3 is an alkyl group or a substituted alkyl group; R 4 is an alkyl group; the wavy line in formula [5] indicates that the stereochemistry of the double bond is E, Z or a mixture of E and Z; the representation of the relative configuration in formula [6] indicates that the stereochemistry of R 3 to the trifluoromethyl group is anti; and and hydrogenolyzing the dehydrogenated closed-ring body, wherein, in the formulae, R 1 is an alkyl group, a substituted alkyl group, an aromatic ring group, a substituted aromatic ring group, an alkoxycarbonyl group or a substituted alkoxycarbonyl group; R 2 is an alkyl group or a substituted alkyl group; the wavy line in formula [1] indicates that the stereochemistry of the double bond is E, Z or a mixture of E and Z; and the wavy line in formula [3] and in formula [4] indicates that the stereochemistry of R 1 to the trifluoromethyl group is syn, anti, or a mixture of syn and anti.