Patent ID: 8606526

Claim:
Bio-sensor and electronic label based apparatus for integrated genomic, proteomic and metabolomic sensing to automate host pharmacokinetic or clinical analysis comprising: bio-sensor for sensing a host genomic value, a host proteomic value, and a host metabolomic value associated with a GPCR condition; electronic label processor coupled to the bio-sensor for comparing electronically a first bioinformatic value with the host genomic value to determine one or more genomic mutant or variant associated with the host, a second bioinformatic value with the host proteomic value to determine one or more proteomic mutant or variant associated with the host, and a third bioinformatic value with the host metabolomic value to determine one or more metabolomic mutant or variant associated with the host; and display coupled to the electronic label processor for alerting electronically a physician, nurse, hospital, pharmacy, paramedic or other professional medical staff a pharmacokinetic or clinical indication based upon the compared first, second and third bioinformatic values to alert such staff one or more determined host genomic, proteomic or metabolomic mutant or variant association with such host susceptibility or predisposition to toxicity or adverse reaction to side effect to identified food, drug or medical treatment; wherein the bio-sensor senses the host genomic value, the host proteomic value, and the host metabolomic value associated with the GPCR condition according to integrated chip refractive-index micro-interferometry detection using coherent VCSEL, laser diode, or He—Ne laser source, etched substrate capillary channel for sample reception and analysis, and reflected laser-light reflection photodetector, said bio-sensor further senses the host genomic value, the host proteomic value, and the host metabolomic value associated with the GPCR condition using optical evanescent wave detector using flow-based surface plasmon resonance in micro-fabricated integrated fluidic cartridge to capture tagged proteins, thiol coupling, or coil-coil interaction, wherein resonance angle is continuously monitored to detect changes in refractive resonance angle and refractive index corresponding to changes in mass when certain ligand binds to, or dissociates from, immobilized binding partner, said bio-sensor further senses the host genomic value, the host proteomic value, and the host metabolomic value associated with the GPCR condition using semiconductor nanocrystal or quantum-dot device as detectable label or probe by linking or bonding to one or more affinity molecules of a detectable substance in an analyte, whereupon such nanocrystal probe in response to a first energy associated with a presence of detectable substance within material bonded to the probe, excites the nanocrystal in the probe and causes the probe to provide a second energy or generate or fluoresce a distinct wavelength signal indicating the presence.