Patent ID: 7186716

Claim:
A compound of the formula I wherein X is N; R 1 and R 9 are independently selected from the group consisting of H, alkyl, aryl, arylsulfonyl, alkylsulfonyl, and a prodrug group selected from the group consisting of C(O)NRR′, C(O)OR′, SO 2 R and C(O)R′; R 2 and R 4 are independently selected from the group consisting of H, alkyl, aryl, heteroaryl, halogen, cyano, NO 2 , NHR′, C(O)R, NHC(O)R, NHSO 2 R′, (CH 2 ) 2 SO 2 (CH 2 ) n R, (CH 2 ) m SO 2 N(R)(CH 2 ) n R′, C(O)NHNRR′, (CH 2 ) n CO 2 R, (CH 2 ) n C(O)NRR′, NHC(O)NHR, (CH 2 ) n NRR′, (CH 2 ) n OR′, and (CH 2 ) n OC(O)R′ wherein said alkyl, aryl or heteroaryl may be further substituted with halogen, NO 2 , hydroxy, carboxylic acid, amino or a heteroalicyclic; R 3 is selected from the group consisting of halogen, NHC(O)R, (CH 2 ) m SO 2 (CH 2 ) n R, (CH 2 )SO 2 N(R)(CH 2 ) n R′, (CH 2 ) n CO 2 R and (CH 2 ) n C(O)NRR′; R 5 , R 6 , R 7 and R 8 are independently selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heteroaryl, halogen, cyano, NO 2 , NRR′, C(O)R, NHC(O)R, (CH 2 ) m SO 2 (CH 2 ) n R, (CH 2 ) n SO 2 NRR′, NHSO 2 R′, (CH 2 ) n CO 2 R′, (CH 2 ) n C(O)NRR′, NHC(O)NHR, (CH 2 ) n NRR′, (CH 2 ) n OR′ trihalomethyl and (CH 2 ) n OC(O)R′; n is 0–3; m is 0–3; R and R′ are independently selected from the group consisting of H, alkyl, heteroaryl, and aryl, wherein alkyl or aryl may be further substituted with halogen, NO 2 , (CH 2 ) n N(R″) 2 , (CH 2 ) n CO 2 R″, (CH 2 ) n OR″, (CH 2 ) n OC(O)R″, alkoxycarbonyl, aryloxycarbonyl, aminocarbonyl, a heteroalicyclic ring, alkyl, alkoxy, —CZ 3 , —OCZ 3 , aryloxy, C(O)NH 2 or heteroaryl; R″ is H, alkyl or aryl; Z is a halogen; alternatively, R and R′, together with the nitrogen to which they are attached, form a 5–7 membered heteroalicyclic ring or a 5–6 membered heteroaryl ring, wherein the heteroalicyclic ring or heteroaryl ring may contain a N, O or S atom in said heteroalicyclic or heteroaryl ring and wherein said heteroalicyclic or heteroaryl ring may be substituted with a moiety selected from the group consisting of alkyl, haloalkyl, alkoxy, hydroxy and halogen; provided that R 4 is bonded to either the 2 or 3 position of the pyrrole ring and the pyrazole ring is bonded to the 2 or 3 position, provided that both R 4 and the pyrazole ring are not bonded to the same position; or a pharmaceutically acceptable salt thereof.