Patent ID: 8892206

Claim:
A method of performing deep brain stimulation (DBS) of a target location in the brain of a patient, the method comprising: implanting at least one stimulation lead in the brain of the patient, the at least one stimulation lead comprising one or several stimulation electrodes and one or several electrochemical sensors; implanting a pulse generator within the patient and coupling the pulse generator to the at least one stimulation lead; operating the pulse generator to stimulate the target location according to a closed-loop feedback, the operating comprising: (i) measuring an impedance between one or several of the electrochemical sensors and a reference electrode by the pulse generator, wherein the reference electrode is one of the stimulation electrodes; (ii) measuring an extracellular level of one or several neurotransmitters using one or several of the electrochemical sensors; (iii) performing a correction operation on the measured extracellular level using the measured impedance and a previously stored impedance value to generate a feedback-loop parameter; and (iv) generating and delivering pulses in response to the generated feedback-loop parameter.