Patent ID: 7736659

Claim:
A method for treating pain in a patient, the method comprising the step of administering to a patient in need thereof a therapeutically effective amount of an agent to reduce pain, wherein the agent comprises a modified Clostridial toxin comprising, a) a Clostridial toxin light chain or fragment thereof that cleaves a neurosecretory protein; b) a Clostridial toxin H N domain or fragment thereof that translocates a Clostridial toxin light chain or light chain fragment thereof across an endosome membrane; and c) a targeting moiety that is a neuropeptide Y polypeptide that binds to a neuropeptide Y receptor; and wherein the H c domain of the modified Clostridial toxin is removed or modified in order to reduce the binding of the modified Clostridial toxin to Clostridial toxin receptors at the neuromuscular junction.