Patent ID: 6979690

Claim:
Compounds of formula (I) and (II): or the pharmaceutically acceptable esters thereof, and the pharmaceutically acceptable salts thereof wherein R 1 is hydrogen, halo, C 1-6 alkyl, aryl or heteroaryl; R 2 and R 3 are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, amino(C 1-5 )alkyl or hydroxy(C 1-5 )alkyl; or two of R 2 and R 3 , or R 3 and R 4 taken together with the nitrogen atom to which they are attached may form a nitrogen-containing heterocycle selected from morpholino, piperazino, piperidino, pyrrolidino, azetidino, pyrazolidino, (1,2,3,4)-tetrahydroisoquinolino, or perhydroisoquinolino; R 4 and R 5 are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl or C 1-6 alkyl substituted by 1 to 6 halogen atom(s); R 6 is hydrogen, C 1-12 alkyl, C 1-6 alkyl-C(═O)(CH 2 ) n , R 11 R 12 N(CH 2 ) n C(═O), C 1-6 alkoxy (C 1-6 )alkyl, C 2-8 alkenyl, C 2-6 alkynyl, aryl, aryl(C 1-6 )alkyl, aryloxy(C 1-6 )alkyl, aryl (C 1-6 )alkoxy (C 1-6 )alkyl or C 1-12 alkyl substituted by up to 3 substituents selected from the groups consisting of halo, cyano, C(═O)R 10 , NR 11 R 12 , R 11 R 12 NC(═O), NR 11 SO 2 R 12 , C 3-8 cycloalkyl, C 1-6 alkyl-S(O) m , aryl, heteroaryl, aryl-S(O) m , hydroxy, oxo and heterocyclic; R 7 and R 8 are hydrogen; R 9 is C 1-6 alkyl or C 3-8 cycloalkyl; R 10 is C 1-6 alkyl, aryl, OR 11 or NR 11 R 12 ; L is (CR 11 R 12 ) n or NR 11 ; M is O, NR 11 or (CR 11 R 12 ) n ; R 11 and R 12 are independently hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl or aryl(C 1-6 )alkyl; n is an integer from 0 to 5; and m is an integer from 0 to 2; said heterocyclic, aryl and heteroaryl are unsubstituted or are substituted by at least one substituent selected from the group consisting of halo, C 1-6 alkyl, amino, hydroxy, cyano, mono- or di-(C 1-6 )alkylamino, C 1-6 alkoxy, aryloxy, aryl (C 1-6 )alkoxy, (C 1-6 )alkoxy carbonyl, di-(C 1-6 ) alkylaminocarbonyl, di-(C 1-6 )alkylamino(C 1-6 )alkoxy, (C 1-6 )alkylsulfonylamino(C 1-6 )alkoxy, C 1-6 alkyl substituted by 1 to 6 halogen atom(s), C 1-6 alkoxy substituted by 1 to 6 halogen atom(s), phenyl, phenoxy substituted by 1 to 5 halogen atom(s) and (C 1-6 )alkoxy(C 1-6 )alkyl, with the proviso that when R 9 is C 1-6 alkyl, then L is not NR 11 ; and when R 9 is C 1-6 alkyl and L is (CR 11 R 12 ), wherein n is 0, then M is not NR 11 .