Patent ID: 8637683

Claim:
A compound of formula (1) having a stereochemical configuration of concanamycin, or a pharmaceutically acceptable salt thereof, wherein R1 is hydroxy or alkoxy; R2 is hydrogen; R3 is methyl; R4 is selected from the following formulae: * indicates point of attachment; R5 is hydroxy; R6 is hydrogen; R7 is hydrogen; R8 is hydroxy; R9 is selected from hydroxy, alkyl, alkoxy, aryl, aralkyl, aryloxy, benzyloxy, heterocyclyl, —O-heterocyclyl, —OCH2COOR17 and —OCH2COR18; R10 is hydroxy; R11 is hydrogen; R12 is hydroxy; R17 is hydrogen or alkyl; R18 is selected from alkyl, —NHCH2R20, aryl and heterocyclyl; and R20 is selected from hydrogen, alkyl, aryl and heterocyclyl; where alkyl is unsubstituted or substituted by one or two of the same or different groups selected from: hydroxy, halogen, amino, hydroxyalkyl, alkoxy, aryl, aryloxy and heterocyclyl; alkoxy is unsubstituted or substituted by one or two of the same or different groups selected from: halogen, hydroxy, alkyl and hydroxyalkyl; aryl is unsubstituted or substituted by one or two of the same or different groups selected from: halogen, hydroxy, amino, alkyl, hydroxyalkyl, alkoxy, aryl and heterocyclyl; heterocyclyl is unsubstituted or substituted by one or two of the same or different groups selected from: halogen, hydroxy, amino, alkyl, hydroxyalkyl, alkoxy, aryl and heterocyclyl.