Patent ID: 7601725

Claim:
A compound of the formula: or pharmaceutically acceptable salt thereof; wherein one of - - - - - is a double bond, as valency permits; X 1 is S, X 2 is —CH—; W 1 is NR W1 , where R W1 is hydrogen, lower alkyl, C 3-6 cycloalkyl, lower heteroalkyl, aryl, -(alkyl)aryl, or acyl; Alk 1 is a C 2 alkylene chain wherein up to two non-adjacent methylene units are independently optionally replaced by —C(═O) or —C(═O)C(═O); L 2 is —NR W2 , —N(R W2 )C(═O)G 2 , —N(R W2 )C(═O)N(R W2 )CR W3 R W4 — or —CR W3 R W4 C(═O)N(R W2 )—; wherein G 2 is absent, O or NR W2 ; and R W2 , R W3 , R W4 and R G2 are independently hydrogen, lower alkyl, lower heteroalkyl, aryl, -(alkyl)aryl, or acyl; Y is a thiazolyl ring; and Z is an aliphatic, heteroaliphatic, alicyclic, aromatic, pyrrolidinyl, pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, piperidinyl, piperazinyl, oxazolidinyl, isoxazolidinyl, morpholinyl, thiazolidinyl, isothiazolidinyl, tetrahydrofuryl, pyridyl, quinolinyl, dihydroquinolinyl, isoquinolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, or furanyl moiety, or Z has one of the following structures: wherein Z is optionally substituted with aliphatic; heteroaliphatic; alicyclic; heteroalicyclic; aromatic, aryl; heteroaryl; alkylaryl; alkylheteroaryl; alkoxy; aryloxy; heteroalkoxy; heteroaryloxy; alkylthio; arylthio; heteroalkylthio; heteroarylthio; F; Cl; Br; I; —NO 2 ; —CN; —CF 3 ; —CH 2 CF 3 ; —CHCl 2 ; —CH 2 OH; —CH 2 CH 2 OH; —CH 2 NH 2 ; —CH 2 SO 2 CH 3 ; or —GR G1 wherein G is —O—, —S—, —NR G2 —, —C(═O)—, —S(═O)—, —SO 2 —, —C(═O)O—, —C(═O)NR G2 —, —OC(═O)—, —NR G2 C(═O)—, —OC(═O)O—, —OC(═O)NR G2 —, —NR G2 C(═O)O—, —NR G2 C(═O)NR G2 —, —C(═S)—, —C(═S)S—, —SC(═S)—, —SC(═S)S—, —C(═NR G2 )—, —C(═NR G2 )O—, —C(═NR G2 )NR G3 —, —OC(═NR G2 )—, —NR G2 C(═NR G3 )—, —NR G2 SO 2 —, —NR G2 SO 2 NR G3 —, or —SO 2 NR G2 —, wherein each occurrence of R G1 , R G2 and R G3 is independently hydrogen, halogen, aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic, aryl, heteroaryl, alkylaryl, or alkylheteroaryl, wherein each heteroalicyclic group is selected from pyrrolidinyl, pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, piperidinyl, piperazinyl, oxazolidinyl, isoxazolidinyl, morpholinyl, thiazolidinyl, isothiazolidinyl, tetrahydrofuryl, dihydropyrrolyl, dihydropyridyl, or azetidinyl, and wherein each heteroaryl group is selected from pyridyl, quinolinyl, dihydroquinolinyl, isoquinolinyl, quinazolinyl, dihydroquinazolinyl, tetrahydroquinazolinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, or furanyl.