Patent ID: 7029860

Claim:
A polypeptide which (a) suppresses or promotes the aggregation of amyloid-β or (b) which is an immunogenic polypeptide, and which is encoded by an isolated polynucleotide selected from the group consisting of: (a) a polynucleotide that comprises a polynucleotide sequence as set forth in SEQ ID NO: 3, 5, 7 or 9, (b) a polynucleotide that encodes a polypeptide having an amino acid sequence as set forth in SEQ ID NO: 4, 6, 8 or 10, (c) a polynucleotide that hybridizes under stringent conditions to a polynucleotide comprising a polynucleotide sequence as set forth in SEQ ID NO: 3, 5, 7 or 9, wherein the stringent conditions comprise washing in 0.1×SSC and 0.1% SDS at 65° C., (d) a polynucleotide that shows at least 95% homology to a polynucleotide sequence as set forth in SEQ ID NO: 3, 5, 7 or 9, and (e) a fragment of the polynucleotide of (a), (b), (c) or (d).