Patent ID: 8703806

Claim:
A method for treating a pulmonary disease or disorder in a patient, the method comprising: providing a metered dose inhaler comprising a canister containing a pharmaceutically acceptable co-suspension, the co-suspension comprising: a suspension medium comprising a pharmaceutically acceptable propellant free of additional constituents; a first species of respirable active agent particles comprising a pharmaceutically acceptable salt, ester, or isomer of glycopyrrolate in crystalline form as a first respirable active agent; one or more additional respirable active agent comprising one or more additional respirable active agent selected from the group consisting of a short-acting beta agonist, a long-acting and ultra long-acting β 2 adrenergic receptor agonist (LABA), a corticosteroid, an anti-inflammatory, an anti-tussive, a bronchodilator, and a muscarinic antagonist; and a plurality of respirable suspending particles, wherein the total mass of the respirable suspending particles exceeds the total mass of the first respirable active agent and the one or more additional respirable active agent, the plurality of suspending particles are formed of a material that is substantially insoluble in the suspension medium, and the first respirable active agent and the one or more additional respirable active agent co-locate with the plurality of suspending particles to form a co-suspension; and administering a therapeutically effective amount of the pharmaceutically acceptable salt, ester, or isomer of glycopyrrolate and the one or more additional respirable active agent to the patient, wherein said administering comprises delivering the co-suspension to the patient by actuating the metered dose inhaler.