Patent ID: 8153385

Claim:
A screening method comprising determining whether or not a test substance regulates the expression or function of a nucleic acid encoding caspase recruitment domain containing protein (CARP), wherein the test substance is a substance that regulates allergic symptoms, a substance that regulates the release of a chemical mediator, or a substance that regulates arrhythmic symptoms, which comprises the following steps (a)-(c): (a) a step for bringing the test substance in contact with (i) CARP or (ii) a mutant protein thereof that consists of the amino acid sequence of SEQ ID NO: 2, wherein 1-30 amino acids have been deleted, substituted, added, or inserted; (b) a step for measuring the functional level of CARP or the mutant protein thereof in the presence of the test substance, and comparing the functional level with that of CARP or the mutant protein thereof in the absence of the test substance; (c) a step for selecting a test substance that alters the functional level of CARP or the mutant protein thereof on the basis of the results of the comparison in step (b) above.