Patent ID: 7919468

Claim:
A method for treating diseases wherein a proteasome is involved, comprising administering to a human or animal organism in need thereof an effective amount of a compound represented by the following general formula (IV): wherein, only one of the bonds c or d is present, provided that: when the bond c is present and d is absent, then R 9 is H; when the bond d is present and c is absent, then R 9 is an oxygen atom O; n 0 is 0 or 1, and when n 0 is 1, X=CH 2 or NCH 2 C 6 H 5 ; R 1 is OH, or a OR 10 group in which R 10 is a linear or branched alkyl group of from 1 to 5 carbon atoms, or a group of formula NH—(CH 2 ) n1 —R 11 in which n 1 =0 or an integer from 1 to 5, R 11 is a linear or branched alkyl group of from 1 to 5 carbon atoms, an aryl group, wherein said alkyl group or said aryl group is optionally substituted, NH 2 , or NHR 12 in which R 12 is a protecting group of amine functions; R 2 is H, or a linear or branched alkyl group of from 1 to 5 carbon atoms, or a group of formula (CH 2 ) n2 —(CO) n3 —NR 13 R 14 , in which n 2 is an integer from 1 to 5, n 3 =0 or 1, R 13 and R 14 , independently from one another, are H, a protecting group of amine functions or a group of formula C(═NH)NHR 15 in which R 15 is H, a protecting group of amine functions or a side chain from proteinogenic amino acids; R 3 is H, or a linear or branched alkyl group of from 1 to 5 carbon atoms, optionally substituted with an aryl group; R 4 is a protecting group of amine functions; and R 7 and R 8 , independently from one another, are H or a halogen atom.