Patent ID: 7576198

Claim:
A compound of the formula (I): wherein X is hydroxy; Y is (1) —C(═R 2 )—R 3 —R 4 wherein R 2 is oxygen atom or sulfur atom, R 3 is oxygen atom, sulfur atom or N—R 5 , R 4 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or optionally substituted aralkyl and R 5 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted cycloalkyl or optionally substituted aralkyl, or R 4 and N—R 5 may be taken together to form optionally substituted non-aromatic heterocyclic group; (2) —S(═O) q —R 6 —R 7 wherein R 6 is oxygen atom or N—R 7 , R 7 each is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or optionally substituted aralkyl and q is 1 or 2; (3) —S(═O) q —R 8 wherein R 8 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or optionally substituted aralkyl and q is as defined above; (4) —P(═O)(OH) 2 ; (5) halogenated alkyl; or (6) optionally substituted heteroaryl; Z is hydrogen or optionally substituted aralkyl; Z 1 and Z 3 each is independently a bond, alkylene or alkenylene; Z 2 is alkylene, a C2 to C6 straight or branched alkenylene, —CH(OH)—, —S—, —SO—, —SO 2 —, —SO 2 NR 10 —, —NR 10 SO 2 —, —O—, —NR 10 —, —NR 10 CO—, —CONR 10 —, —C(═O)—O—, —O—C(═O)— or —CO—; R 10 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or optionally substituted aralkyl; R 1 is optionally substituted branched alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted non-aromatic heterocyclic group, optionally substituted aryl or optionally substituted heteroaryl; p is 1 to 2, provided that when p is 2, the groups of the formula: —Z 1 —Z 2 —Z 3 —R 1 are different from each other; ring (A) is optionally further substituted aromatic heterocycle; and the group of the formula: —C(Z)═C(X)Y in the formula (I) substitutes at an atom adjacent to a hetero atom in ring (A), or a tautomer of the compound.