Patent ID: 7256007

Claim:
A method for identifying a modulator of interaction between a human or murine SOCS-3 molecule and a gp130 receptor, said method comprising: immobilizing said SOCS-3 molecule or a part thereof to a solid support, wherein said part comprises the SH2 domain of said SOCS-3 molecule; contacting the immobilized SOCS-3 molecule or the part thereof with said gp 130 receptor or a part of said gp130 receptor in the presence of a potential agonist or antagonist, wherein said part of said gp130 receptor comprises the cytoplasmic domain of said gp130 receptor or at least SEQ ID NO:5; and measuring qualitatively or quantitatively a change in binding between said SOCS-3 or said part of said SCOS-3 and said gp130 receptor or said part of said gp130 receptor, as compared to binding in the absence of said potential agonist or antagonist, thereby identifying a modulator of interaction between said SOCS-3 molecule and said gp130 receptor.