Patent ID: 8497372

Claim:
A method of treating age-related macular degeneration mediated by kinase insert domain receptor activity comprising administering to a subject in need thereof an effective amount of a compound of the following formula: wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , R 9 , and R 10 , independently, is H, halo, amino, hydroxy, alkyl, alkenyl, alkynyl, heterocycloalkyl, alkoxy, alkylthio, carboxy, alkoxycarbonyl, carbonylamino, or sulfonylamino; R 6 is alkyl; R 7 is alkoxycarbonyl, aminocarbonyl, or aminosulfonyl; X is O; and Z is N; wherein each of alkyl, alkenyl, alkynyl, heterocycloalkyl, and alkoxy is optionally substituted with at least one substituent chosen from halo, hydroxy, amino, cyano, nitro, mercapto, alkoxycarbonyl, amido, carboxy, alkanesulfonyl, alkylcarbonyl, carbamido, carbamoyl, thioureido, thiocyanato, sulfonamido, alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl.