Patent ID: 7045545

Claim:
The compounds of Formula I: where: A is —CHR 13 — or a bond and is attached at the 7-position of the benzofuran ring; R is hydrogen, halo, cyano, —C(O)NR 6 R 7 , C 1 –C 6 alkyl, C 1 –C 4 alkoxycarbonyl, carboxy, or phenyl optionally substituted with one or two substituents selected from the group consisting of halo, C 1 –C 4 alkyl, and C 1 –C 4 alkoxy; R 1 is hydrogen; R 2 and R 3 are independently hydrogen, halo, amino, nitro, C 1 –C 4 alkoxy, cyano, carboxamido, —C(O)NR 8 R 9 , —NR 10 R 11 , —NHC(O)NHR 14 , C 1 –C 4 alkoxycarbonyl, carboxyl, trifluoromethyl, or C 1 –C 6 alkyl optionally substituted with a substituent selected from the group consisting of C 1 –C 4 alkoxy, hydroxy, phenoxy, and phenyl; R 4 and R 4′ are independently hydrogen, C 1 –C 4 alkyl, or benzyl; or R 4 and R 4′ together with the carbon atom to which they are attached form a cyclopropyl moiety; R 5 is hydrogen, C 1 –C 4 alkyl, or benzyl; R 5′ is hydrogen, or R 5 and R 5′ together with the carbon atom to which they are attached form a cyclopropyl moiety; R 6 and R 7 are independently hydrogen or C 1 –C 4 alkyl; R 8 is hydrogen or C 1 –C 4 alkyl; R 9 is C 1 –C 8 alkyl where the alkyl chain is optionally substituted with a substituent selected from the group consisting of carboxy, phenyl, or pyridyl, said phenyl or pyridyl substituent optionally substituted with one or two substituents selected from the group consisting of halo, C 1 –C 4 alkyl, or C 1 –C 4 alkoxy; R 10 is hydrogen or C 1 –C 4 alkyl; R 11 is C 1 –C 4 alkyl or C 1 –C 4 acyl; R 12 is hydrogen, halo, or C 1 –C 4 alkyl; R 13 is hydrogen, C 1 –C 4 alkyl, or benzyl; R 14 is hydrogen, C 1 –C 4 alkyl, or phenyl optionally substituted with a substituent selected from the group consisting of halo, C 1 –C 4 alkyl, and C 1 –C 4 alkoxy; or pharmaceutically acceptable acid addition salts thereof.