Patent ID: 8906917

Claim:
A method of modulating a glucocorticoid receptor, comprising contacting a glucocorticoid receptor with an effective amount of a compound of Formula I and detecting a change in the activity of the glucocorticoid receptor, wherein the compound of Formula I has the structure: wherein the dashed line is absent or a bond; X is selected from the group consisting of O and S; R 1 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, optionally substituted with from 1 to 3 R 1a groups; each R 1a is independently selected from the group consisting of H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkyl-OR 1b , halogen, C 1-6 haloalkyl, C 1-6 haloaloxy, —OR 1b , —NR 1b R 1c , —C(O)R 1b , —C(O)OR 1b , —OC(O)R 1b , —C(O)NR 1b R 1c , —NR 1b C(O)R 1c , —SO 2 R 1b , —SO 2 NR 1b R 1c , cycloalkyl, heterocycloalkyl, aryl and heteroaryl; R 1b and R 1c are each independently selected from the group consisting of H and C 1-6 alkyl; R 2 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkyl-OR 1b , C 1-6 alkyl-NR 1b R 1c and C 1-6 alkylene-heterocycloalkyl; R 3 is selected from the group consisting of H and C 1-6 alkyl; Ar is aryl, optionally substituted with 1-4 R 4 groups; each R 4 is independently selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkoxy, halogen, C 1-6 haloalkyl and C 1-6 haloalkoxy; L 1 is a bond or C 1-6 alkylene; subscript n is an integer from 0 to 3, and salts and isomers thereof, thereby modulating the glucocorticoid receptor.