Patent ID: 8637559

Claim:
An oxazole compound represented by Formula (1) wherein R 1 is an aryl group which may have one or more substituents selected from the following (1-1) to (1-11): (1-1) hydroxy groups, (1-2) unsubstituted or halogen-substituted lower alkoxy groups, (1-3) lower alkenyloxy groups, (1-4) lower alkynyloxy groups, (1-5) cyclo C 3-8 alkyl lower alkoxy groups, (1-6) cyclo C 3-8 alkyloxy groups, (1-7) cyclo C 3-8 alkenyloxy groups, (1-8) dihydroindenyloxy groups, (1-9) hydroxy lower alkoxy groups, (1-10) oxiranyl lower alkoxy groups, and (1-11) protected hydroxy groups; R 2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents selected from the following (2-1) to (2-10): (2-1) hydroxy groups, (2-2) unsubstituted or halogen-substituted lower alkoxy groups, (2-3) unsubstituted lower alkyl groups, (2-4) lower alkenyloxy groups, (2-5) halogen atoms, (2-6) lower alkanoyl groups other than a formyl group, (2-7) lower alkylthio groups, (2-8) lower alkylsulfonyl groups, (2-9) oxo groups, and (2-10) lower alkoxy lower alkoxy groups; and the nitrogen atom-containing heterocyclic group in R 2 is selected from imidazolidinyl, hexahydropyrimidinyl, piperazinyl, octahydroisoindolyl, azocanyl, pyrrolyl, dihydropyrrolyl, imidazolyl, dihydroimidazolyl, triazolyl, dihydrotriazolyl, pyrazolyl, pyridyl and N-oxides thereof, dihydropyridyl, pyrimidinyl, dihydropyrimidinyl, pyrazinyl, dihydropyrazinyl, pyridazinyl, tetrazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, hexahydroisoindolinyl, benzoimidazolyl, quinolyl, isoquinolyl, indazolyl, quinazolinyl, dihydroquinazolinyl, benzotriazolyl, carbazolyl, oxazolyl, isooxazolyl, oxadiazolyl, oxazolidinyl, isooxazolidinyl, dihydrobenzoxazolyl, benzoxazinyl, dihydrobenzoxazinyl, benzoxazolyl, benzooxadiazolyl, thiazolyl, dihydrothiazolyl, isothiazolyl, thiadiazolyl, dihydrothiazinyl, thiazolyzinyl, benzothiazolyl, and benzothiadiazolyl; and W is a divalent group represented by Formula (i) or (ii): —Y 1 -A 1 - Formula (i) —Y 2 —C(═O)— Formula (ii) wherein A 1 is a lower alkenylene group, or a lower alkylene group which may have one or more substituents selected from the group consisting of hydroxy groups and lower alkoxycarbonyl groups, Y 1 is —C(═O)—, —C(═O)—N(R 3 )—, —S(O) m —NH—, or —S(O) n — wherein R 3 is a hydrogen atom or a lower alkyl group, and m and n are each independently an integer from 0 to 2, and Y 2 is a piperazinediyl group, or a divalent group represented by Formula (iii): —C(═O)-A 2 -N(R 5 )— Formula (iii) wherein A 2 is a lower alkylene group, and R 5 is a hydrogen atom or a lower alkyl group; or a pharmaceutically acceptable salt thereof.