Patent ID: 7666604

Claim:
A soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof, wherein (i) and (ii) each comprise a variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain cysteine residues substituted for Thr 48 of exon 1 of TRAC*01 and Ser 57 of exon 1 of TRBC1*01 or TRBC2*01, wherein Thr 48 is amino acid 10 of SEQ ID NO:1 and wherein Ser 57 is amino acid 10 of SEQ ID NO:5 characterized in that the sTCR binds a CD1-antigen complex, wherein one or both of (i) and (ii) comprise all of the extracellular constant immunoglobulin domain of the TCR chain.