Patent ID: 7078430

Claim:
A compound of formula 1 wherein R 1 is C 1 –C 6 alkyl; C 3 –C 7 cycloalkyl; or unsubstituted or optionally substituted phenyl having the phenyl substituents halogen, C 1 –C 6 alkyl, cyano or C 1 –C 3 perfluoroalkyl; R 2 is unsubstituted or optionally substituted phenyl having the phenyl substituents cyano; acetyl; or unsubstituted or optionally substituted amino having the amino substituents C 1 –C 6 alkyl, C 3 –C 7 cycloalkyl, or acetyl; R 3 is unsubstituted or optionally substituted C 1 –C 6 alkyl or C 3 –C 7 cycloalkyl having the alkyl or cycloalkyl substituents halogen; perfluoroalkyl; unsubstituted or optionally substituted amino having the amino substituents C 1 –C 6 alkyl, C 3 –C 7 cycloalkyl, or acetyl; hydroxyl; C 1 –C 3 alkoxy; protected hydroxyl; carboxyl; or C 1 –C 3 alkoxycarbonyl; R 4 and R 5 are independently hydrogen; C 1 –C 6 alkyl; C 1 –C 3 cycloalkyl; or wherein n=0 or 1 and R 6 , R 7 , R 8 , R 9 & R 10 are independently selected from hydrogen; halogen; hydroxyl; protected hydroxyl; C 1 –C 6 alkoxy; unsubstituted or optionally substituted C 1 –C 6 alkyl having the alkyl substituents hydroxyl or protected hydroxyl; unsubstituted or optionally substituted amino having the amino substituents SO 2 R 11 , COR 11 , CONH R 11 , wherein R 11 is C 1 –C 6 alkyl, or aryl; cyano; acetyl; trifluoromethyl; C 1 –C 6 alkoxycarbonyl; or two successive positions of the phenyl ring substituted by an unsubstituted or optionally substituted methylene dioxy group having the structure wherein R 12 is C 1 –C 3 alkyl; with the provisio that when n=0 at least one of R 6 , R 7 , R 8 , R 9 & R 10 is hydroxyl or protected hydroxyl, with the further provisio that if only one of R 6 , R 7 , R 8 , R 9 & R 10 is hydroxyl or protected hydroxyl, then at least one of the other substituents is not hydrogen; wherein Y is including the tautomers, racemates, pure enantiomers and diastereoisomers, N-oxides, or solvates of the compound of formula I.