Patent ID: 7482454

Claim:
A process for preparing a compound according to the steps shown in Scheme I: wherein B1 and P are protecting groups; and n is 1-3; wherein the resulting compound is a compound according to Formula (I): wherein: (a) X is selected from the group consisting of (b) R1 is selected from the group consisting of C 3 to about C 5 cycloalkyl, C 1 to about C 2 alkanyl, C 2 to about C 3 linear alkenyl, C 3 to about C 4 branched alkanyl or alkenyl, all such alkyl or cycloalkyl moieties being unsubstituted or substituted with from 1 to about 3 fluoro; and phenyl, unsubstituted or substituted with from 1 to about 3 fluoro, or with one hydroxy in the 4-position; (c) R3 is hydroxy; (d) R5 is selected from the group consisting of hydrogen, hydroxy, amino, halo, C 1 to about C 2 alkanyl, C 2 alkenyl, and methoxy, all such alkyl and methoxy moieties being unsubstituted or substituted with from 1 to about 3 fluoro; (e) R6 is hydrogen; (f) R8 is unsubstituted methoxy, methylthio, or C 1 to about C 2 alkanyl; (g) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C 1 to about C 3 alkanyl; or aminoalkanyl which is attached to any ring carbon of X and is C 1 to about C 3 alkanyl substituted with one amino, the amino being unsubstituted or substituted with one or two C 1 to about C 3 alkanyl; wherein when X comprises a pyrrolidinyl ring, R7 is aminoalkanyl which is attached to any ring carbon of X and is C 1 to about C 3 alkanyl substituted with one amino, the amino being unsubstituted or substituted with one or two C 1 to about C 3 alkanyl; (h) each R9 is independently selected from the group consisting of hydrogen, C 1 to about C 4 alkanyl, C 2 to about C 6 alkenyl or alkynyl, and a C 3 to about C 6 fused or spirocycle alkyl ring; or one R9 may optionally be selected from the group consisting of hydroxy, C 1 to about C 4 alkoxy, aryl and heteroaryl, all other R9 being hydrogen; all alkyl and aryl portions of R9 moieties being unsubstituted or substituted with one hydroxy or with from 1 to about 3 fluoro; and (i) a R7 moiety described in (g) and a R9 moiety described in (h) may optionally be connected thus forming a fused or spirocycle ring with the N-containing ring shown in (a), the fused or spirocycle ring comprising from 2 to about 5 ring carbons and 0 or 1 ring nitrogen; or an optical isomer, diastereomer or enantiomer thereof; or a pharmaceutically-acceptable salt, thereof.