Patent ID: 7456167

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is hydroxy, alkoxy, benzyloxy, amino, alkylamino, dialkylamino, (aminoalkyl)amino, (aminoalkyl)(alkyl)amino, di(aminoalkyl)amino, ((alkylamino)alkyl)amino, ((alkylamino)alkyl)(alkyl)amino, di((alkylamino)alkyl)amino, ((dialkylamino)alkyl)amino, ((dialkylamino)alkyl)(alkyl)amino, di((dialkylamino)alkyl)amino, ((COR 11 )alkyl)amino, ((COR 11 )alkyl)(alkyl)amino, alkyl, haloalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or (R 12 )alkyl; or R 2 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from the group consisting of hydroxy, amino, alkylamino, dialkylamino, alkyl, alkoxyalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, alkylSO 2 , and haloalkylSO 2 ; or R 2 is a [4.3.0] or [3.3.0] bicyclic diamine attached to the SO 2 moiety through one nitrogen, and is substituted with 0-2 R 8 substituents; R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, alkoxy, or haloalkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 ) 2 NSO 2 , or (R 10 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl; R 9 is hydrogen, alkyl, or cycloalkyl; and R 10 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 alkyl substituents; R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, N-alkylhomopiperazinyl, or homomorpholinyl; and R 12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, N-alkylhomopiperazinyl, or homomorpholinyl; or a pharmaceutically acceptable salt thereof.