Patent ID: 8586712

Claim:
An antibody that binds ICAM-1 comprising: (i) a V H region of SEQ ID NO:9, and a V L region of SEQ ID NO:11; (ii) a V H region of SEQ ID NO:9, and a variant V L region of SEQ ID NO:11; (iii) a variant V H region of SEQ ID NO:9, and a V L region of SEQ ID NO:11; or (iv) a variant V H region of SEQ ID NO:9, and a variant V L region of SEQ ID NO:11; wherein the variant V H region comprises one or more amino acid substitutions at positions 37, 61, 62, 63, 64, 65, 70, 72, 74, and 98 of SEQ ID NO:9; and wherein the variant V L region comprises an amino acid substitution at position 49 of SEQ ID NO:11.