Patent ID: 7132539

Claim:
A compound having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R 1 is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyl; R 5a and R 5b are each independently selected from the group consisting of i) hydrogen; ii) C 1 –C 12 hydrocarbyl selected from the group consisting of: a) C 1 –C 12 linear or branched, substituted or unsubstituted alkyl; and b) C 3 –C 12 substituted or unsubstituted cycloalkyl; iii) —COR 4 ; iv) —COOR 4 ; v) —CON(R 4 ) 2 ; vi) —N(R 4 ) 2 ; vii) —NR 4 C(═NR 4 )N(R 4 ) 2 ; viii) —SO 2 N(R 4 ) 2 ; and ix) R 5a and R 5b can be taken together to form a carbocyclic ring having from 3 to 10 atoms; R 4 units are hydrocarbyl units each of which is independently selected from the group consisting of: i) hydrogen; ii) C 1 –C 12 hydrocarbyl selected from the group consisting of: a) C 1 –C 12 linear, branched, or cyclic alkyl; and b) C 6 –C 12 aryl; R 7a is selected from the group consisting of i) hydrogen; ii) —CO 2 H; iii) —CO 2 CH 3 ; iv) —CONH 2 ; v) —CONHCH 3 ; vi) —CON(CH 3 ) 2 ; vii) —CONH(CH 2 CH 2 F); viii) —CONCH(CH 3 ) 2 ; ix) —CONH(C 3 H 5 ); x) —CONHCH 2 (C 3 H 5 ); R 8 is selected from the group consisting of benzyl, (2-chlorophenyl)methyl, (3-chlorophenyl)methyl, (4-chlorophenyl)methyl, (3,4-dichlorophenyl)methyl, (2-fluorophenyl)-methyl, (3-fluorophenyl)methyl, (4-fluorophenyl)methyl, and naphthalen-2-ylmethyl.