Patent ID: 7351725

Claim:
A compound of Formula I or a pharmaceutically acceptable salt or hydrate thereof, wherein: Ar is phenyl; A is —CO 2 H; n is 2, 3 or 4; each R 1 and R 2 is independently selected from the group consisting of: hydrogen, halo, hydroxy, —CO 2 H, C 1-6 alkyl and phenyl, said C 1-6 alkyl and phenyl optionally substituted with 1-3 halo groups; R 3 is selected from the group consisting of: hydrogen and C 1-4 alkyl, optionally substituted with 1-3 hydroxy or halo groups; each R 4 is independently selected from the group consisting of: hydroxy, halo, —CO 2 H, C 1-4 alkyl, —S(O) k C 1-3 alkyl, wherein k is 0, 1 or 2, C 1-3 alkoxy, C 3-6 cycloalkoxy, aryl and aralkoxy, the alkyl portions of said C 1-4 alkyl, —S(O) k C 1-3 alkyl, C 1-3 alkoxy and C 3-6 cycloalkoxy optionally substituted with 1-3 halo groups; C is HET, wherein HET is thienyl; B is selected from the group consisting of: C 1-6 alkyl, C 1-5 alkoxy, —(C═O)—C 1-5 alkyl, —(C═O)—O—C 1-4 alkyl, —(C═O)—N(R 6 )(R 7 )—C 1-4 alkyl, phenyl and HET; and R 6 and R 7 are independently selected from the group consisting of: hydrogen, C 1-9 alkyl and —(CH 2 ) p -phenyl, wherein p is 1 to 5 and phenyl is optionally substituted with 1-3 substituents independently selected from the group consisting of: C 1-3 alkyl and C 1-3 alkoxy, each optionally substituted with 1-3 halo groups.