Patent ID: 8128907

Claim:
A method for providing a cerebrospinal fluid (CSF) correction factor for CSF obtained from a patient suffering from a disease selected from the group consisting of Alzheimer's Disease and Mild Cognitive Impairment (MCI) for at least one biomarker selected from the group consisting of a Tau protein and an amyloid beta (Aβ), comprising the steps of: (a) measuring levels of said at least one biomarker in samples of CSF obtained from the patient; (b) providing semi-automated measurements of the ventricular system using quantitative anatomical protocols; (c) correcting the concentration dilution level in the CSF of said at least one biomarker measured in step a) by using a computer algorithm that analyzes volume and longitudinal changes in CSF measurements obtained in step (b); and (d) providing the CSF correction factor for level of concentration of said at least one biomarker due to increased ventricular volume of CSF caused by an increase in ventricular size.