Patent ID: 8450486

Claim:
A method of treating breast cancer comprising administering to the subject a therapeutically effective amount of a compound of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0, 1 or 2; X is N or CR 7 , wherein R 7 is hydrogen; R 1 is C 1-6 alkyl or thiophenyl; R 2 is selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, and C 3-6 alkynyl; R 3 is a radical selected from the group consisting of —(CH 2 ) s —NR 8 R 9 , —O—H, —O—R 10 , —S—R 11 , and —C≡N, wherein s is 0, 1, 2 or 3 and R 8 , R 10 and R 11 are each independently selected from the group consisting of —CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonylaminoC 1-6 alkyl, piperidinyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, thiophenylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindozolylpiperidinylC 1-6 alkyl, andarylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl, and R 9 is hydrogen or C 1-6 alkyl; or R 3 is a group of formula —(CH 2 ) t —Z wherein t is 0, 1, 2 or 3; and —Z is a heterocyclic ring system selected from the group consisting of wherein R 12 is selected from the group consisting of hydrogen, halo, C 1-6 alkyl, aminocarbonyl, amino, hydroxy, aryl, C 1-6 alkylaminoC 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, arylC 1-6 alkyl, di(phenylC 2-6 alkenyl), piperidinyl, piperidinylC 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, arylC 1-6 alkylamino, morpholino, C 1-6 alkylimidazolyl, and pyridinylC 1-6 alkylamino; and R 13 is hydrogen, piperidinyl or aryl; R 4 , R 5 and R 6 are each independently selected from hydrogen, halo, trihalomethyl, trihalomethoxy, C 1-6 alkyl, C 1-6 alkyloxy, amino, aminoC 1-6 alkyl, di(C 1-6 alkyl)amino, di(C 1-6 alkyl)aminoC 1-6 alkyloxy or C 1-6 alkyloxycarbonyl, or C 1-6 alkyl substituted with 1, 2 or 3 substituents independently selected from hydroxy, C 1-6 alkyloxy, or aminoC 1-6 alkyloxy; or when R 5 and R 6 are on adjacent positions they may taken together form a bivalent radical of formula —O—CH 2 —O (d-1), —O—(CH 2 ) 2 —O— (d-2), —CH═CH—CH═CH— (d-3), or —NH—C(O)—NR 14 ═CH— (d-4), wherein R 14 is C 1-6 alkyl; aryl is phenyl, phenyl substituted with halo, C 1-6 alkyl or C 1-6 alkyloxy.