Patent ID: 7579368

Claim:
A compound of formula I: and the pharmaceutically acceptable salts and esters thereof, wherein X 1 is selected from the group consisting of: lower alkoxy, lower alkoxy substituted by trifluoromethyl or fluorine; X 2 and X 3 are independently selected from the group consisting of: hydrogen, halogen, cyano, lower alkyl, lower alkoxy, —NX 4 X 5 , —SO 2 NX 4 X 5 , —C(O)NX 4 X 5 , —C(O)X 6 , —SOX 6 , —SO 2 X 6 , —NC(O)-lower alkoxy —C≡C—X 7 , with the proviso that X 2 and X 3 are both not hydrogen, lower alkyl, or lower alkoxy, with the proviso that when X 2 or X 3 is hydrogen, the other is not lower alkyl, lower alkoxy, or halogen, X 2 and X 3 can be taken together to form a ring selected from 5 to 7 membered unsaturated rings, and 5 to 7 membered unsaturated rings that contain at least one hetero atom selected from S, N, and O; X 4 and X 5 are independently selected from the group consisting of: hydrogen, lower alkyl, cycloalkyl, lower alkoxy, lower alkyl substituted with lower alkoxy, —C(O)X 6 , —SO 2 X 6 , X 4 and X 5 can be taken together to form a ring selected from 5 to 7 membered unsaturated rings, and 5 to 7 membered unsaturated rings that contain at least one hetero atom selected from S, N, and O; X 6 is selected from the group consisting of: lower alkyl, morpholine, piperidine, piperazine, 2-piperazinone, pyrrolidine; X 7 is selected from the group consisting of: hydrogen, lower alkyl, trifluoromethyl; Y 1 and Y 2 are independently selectect from the group consisting of: halogen, acetylene; R is selected from the group consisting of: lower alkoxy, piperidinyl substituted by five or six membered heterocycle, piperidinyl substituted by hydroxy, —CH 2 OH, or —C(O)NH 2 , piperazinyl substituted by R 1 , [1,4]diazepanyl substituted by R 1 , R 1 is one or two substituents selected from the group consisting of: hydrogen, oxo, lower alkyl substituted by R 2 , —C(O)R 3 , —SO 2 —R 3 ; R 2 is selected from the group consisting of: —SO 2 -lower alkyl, hydroxy, lower alkoxy, trifluoromethyl, —NH—SO 2 -lower alkyl, —NH—C(O)-lower alkyl, —C(O)-lower alkyl, -cyano, —C(O)R 4 ; R 3 is selected from the group consisting of: five membered heterocycle, lower alkyl, cycloalkyl, lower alkyl substituted by lower alkoxy, lower alkyl substituted by piperazinyl substituted by R 1 , —N-cycloalkyl, lower alkoxy; R 4 is selected from the group consisting of: hydroxy, lower alkoxy, morpholine, piperidine, pyrrolidine, piperazinyl substituted by R 1 , aziridine, —NR 5 R 6 ; R 5 and R 6 are independently selected from the group consisting of: hydrogen, lower alkyl, lower alkyl substituted by lower alkoxy or cyano, lower alkoxy.