Patent ID: 8431602

Claim:
A compound of formula I in which R 1 denotes Ar or Het, R 2 , R 2′ , R 2″ denote H, R 3 denotes Het, R 4 , R 5 denote H, R 6 denotes H, R 7 , R 8 denote H, R 9 , R 10 denote H, R 11 denotes H or A, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are optionally replaced by F and/or Cl, Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by A, Hal and/or O(CR 9 R 10 ) m R 11 , Het denotes a mono- or bicyclic unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which are optionally mono-, di- or trisubstituted by Hal, A and/or (CR 9 R 10 ) m COOR 11 , Hal denotes F, Cl, Br or I, and m denotes 0, 1, 2, 3 or 4, or a pharmaceutically acceptable salt thereof, excluding the following compounds: N-(5-Bromo-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propionamide, N-(5-Chloro-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propionamide, 3-(3,4-Dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-N-pyridine-2-yl-propionamide, 3-(1-oxo-1,3-dihydro-isoindole-2-yl)-N-pyridine-2-yl-3-(3,4,5-trimethoxy-phenyl)-propionamide, N-(5-Bromo-pyridine-2-yl)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, N-(5-Chloro-pyridine-2-yl)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, N-(5-Methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propionamide, N-(5-Chloro-pyridine-2-yl)-3-(4-fluoro-phenyl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, 3-(3,4-Dimethoxy-phenyl)-N-(5-methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, N-(5-Bromo-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-3-p-tolyl-propionamide, 3-(1-oxo-1,3-dihydro-isoindole-2-yl)-N-pyridin-2-yl-3-thiophene-2-yl-propionamide, 3-(4-Methoxy-phenyl)-N-(6-methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, N-(6-Methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propionamide, 3-(4-Methoxy-phenyl)-N-(4-methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, 3-(3,4-Dimethoxy-phenyl)-N-(6-methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, 3-(4-Methoxy-phenyl)-N-(5-methyl-pyridine-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-propionamide, 3-(4-Methoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-N-pyridine-2-yl-propionamide, N-(4-Methyl-thiazole-2-yl)-3-(1-oxo-1,3-dihydro-isoindole-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propionamide, and 3-(1-oxo-1,3-dihydro-isoindole-2-yl)-N-thiazole-2-yl-3-(3,4,5-trimethoxy-phenyl)-propionamide.