Patent ID: 8907153

Claim:
An adhesive peel-forming formulation for dermal delivery of a drug, comprising: a) a drug, wherein the drug comprises less than 10 wt % of the formulation; b) a solvent vehicle, comprising: i) a volatile solvent system comprising one or more volatile solvent, and ii) a non-volatile solvent system comprising one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility with respect to the drug that is within a window of operable solubility such that the drug is deliverable at therapeutically effective rates over a sustained period of time, and wherein the non-volatile solvent system comprises greater than 20 wt % of the formulation; and c) a peel-forming agent, wherein the peel-forming agent comprises 20.8 wt % to 40.9 wt % of the formulation excluding the drug, wherein the formulation has a viscosity suitable for application ranging from 1,000 cPs to 1,000,000 cPs, and adhesion to a skin surface prior to evaporation of the volatile solvent system, wherein the formulation applied to the skin surface forms a coherent and soft solidified peelable layer without a backing after at least partial evaporation of the volatile solvent system, and wherein the drug continues to be delivered after the volatile solvent system is substantially evaporated, and wherein the solidified peelable layer has sufficient tensile strength so that it can be peeled off the skin in one piece or several large pieces.