Patent ID: 7279476

Claim:
A compound of formula I: or a pharmaceutically acceptable derivative thereof, wherein: B is selected from a group consisting of C 6-10 aryl, heteroaryl having 5–10 ring atoms, or heterocyclyl having 3–10 ring atoms; wherein B has the substituent -L-A and 0–3 R 2 substituents; and wherein B is optionally furher substituted; L is a bond or an optionally substituted C 1 –C 8 alkylidene chain, wherein up to 2 methylene units are optionally replaced by —O—, —C(O)—, —C(O)C(O)—, —C(O)N(R 8 )—, —C(O)N(R 8 )N(R 8 )—, —O 2 —, —OC(O)—, —N(R 8 )CO 2 —, —N(R 8 )C(O)N(R 8 )—, —OC(O)N(R 8 )—, —N(R 8 )—, —N(R 8 )N(R 8 )—, —N(R 8 )CO—, —S—, —SO—, —SO 2 —, —SO 2 N(R 8 )—, —N(R 8 )SO 2 —, —N(R 8 )SO 2 N(R 8 )—, —N(R 8 )O—, or —ON(R 8 )—; A is -het, het is an optionally substituted group selected from heteroaryl having 5–10 ring atoms, or heterocyclyl having 3–10 ring atoms; Q is an optionally substituted C 1 –C 6 alkylidene chain; wherein up to two methylene units are replaced by —C(O)—, —C(O)C(O)—, —C(O)NR 7 —, —C(O)NR 7 NR 7 —, —CO 2 —, —OC(O)—, —NR 7 CO 2 —, —O—, —NR 7 C(O)NR 7 —, —OC(O)NR 7 —, —NR 7 NR 7 —, —NR 7 C(O)—, —S—, —SO—, —SO 2 —, —NR 7 —, —SO 2 NR 7 —, —NR 7 SO 2 —, or —NR 7 SO 2 NR 7 —; n is zero or one; R 1 is hydrogen, R, fluoro, N(R 7 ) 2 , OR 7 , NR 7 C(O)R 7 , NR 7 C(O)N(R 7 ) 2 , C(O)N(R 7 ) 2 , SO 2 R 7 , NR 7 SO 2 R 7 , or SO 2 N(R 7 ) 2 ; each R 2 is independently R, OH, OR, SN, SR, nitro, N(R 7 ) 2 , halogen, CF 3 , or cyano; R 3 is hydrogen, R, OH, OR, N(R 7 ) 2 , fluoro, or CN; R 4 selected from —(CH 2 ) y R 6 , —(CH 2 ) y R 10 , —(CH 2 ) y CH(R 6 ) 2 , —(CH 2 ) y CH(R 10 ) 2 , —(CH 2 ) y CH(R 10 )CH(R 6 ) 2 , —(CH 2 ) y CH(R 10 )(R 6 ), —N(R 5 ) 2 , or —NR 5 (CH 2 ) y N(R 5 ) 2 ; each R is independently selected from an optionally substituted group selected from the group consisting of C 1-6 aliphatic, C 6-10 aryl, heteroaryl having 5–10 ring atoms, and heterocyclyl having 3–10 ring atoms; each R 5 is independently selected from R, —(CH 2 ) y R 6 , —(CH 2 ) y CH(R 6 ) 2 , R 7 , —C(O)R 7 , —CO 2 R 7 , —C(O)N(R 7 ) 2 , or —SO 2 R 7 ; each y is independently 0–6; each R 6 is independently selected from hydrogen, R, —(CH 2 ) y R, —OH, —OR, —CO 2 R, —(CH 2 ) y N(R 7 ) 2 , —N(R 7 ) 2 , —OS 7 , —SR 7 , —NR 7 C(O)R 7 , —NR 7 C(O)N(R 7 ) 2 , —C(O)N(R 7 ) 2 , —SO 2 R 7 , —NR 7 SO 2 R 7 , —C(O)R 7 , —CN, or —SO 2 N(R 7 ) 2 , each R 7 is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or two R 7 the same nitrogen are taken together with the nitrogen to optionaily form a 5–8 membered heterocydlic or heteroaryl ring; each R 8 is independently selected from hydrogen, R, —(CH 2 ) y R 9 , —(CH 2 ) y CH(R 9 ) 2 , —C(O)R 9 , R 9 , or R 7 ; each R 9 is as defined in R 6 ; each R 10 is independently selected from R, —(CH 2 ) w OR 7 , —(CH 2 ) w N(R 5 ) 2 , or —(CH 2 ) w SR 7 ; and each w is independently 0–4; provided that when Q n -R 4 is R 1 is H, R 3 is H, B is phenyl, and R 2 is a meta substituent Cl, then -L-A is not a para substituent