Patent ID: 8722889

Claim:
A compound of formula (I-E): or pharmaceutically acceptable salts thereof, wherein: R 1 is T-R′ or is —Si(R′) 3 ; R 2 , R 3 , and R 4 are each independently halogen, CN, NO 2 , or V—R′; x is 1, 2, 3, or 4; each occurrence of R 5 is independently halogen, CN, NO 2 , or U—R′, wherein at least one R 5 is other than H; T, V, and U are each independently a bond or an optionally substituted C 1 -C 6 alkylidene chain, wherein up to two methylene units of the chain are optionally and independently replaced by —NR′—, —S—, —O—, —CS—, —CO 2 —, —OCO—, —CO—, —COCO—, —CONR′—, —NR′CO—, —NR′CO 2 —, —SO 2 NR′—, —NR′SO 2 —, —CONR′NR′—, —NR′CONR′—, —OCONR′—, —NR′NR′—, —NR′SO 2 NR′—, —SO—, —SO 2 —, —PO—, —PO 2 —, or —POR′—; and each occurrence of R′ is independently hydrogen or an optionally substituted group selected from a C 1 -C 6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or two occurrences of R′, are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, provided that: a) if R 2 , R 3 and R 4 are simultaneously H, then R 1 is not Si(R′) 3 ; and b) if R 1 , R 2 and R 4 are simultaneously H, then R 3 is not phenyl or phenyl substituted with O-phenyl or N(Me) 2 .