Patent ID: 8865711

Claim:
A compound having the structure I wherein HET is selected from the group consisting of imidazo[1,2-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, and [1,2,4]triazolo[1,5-c]pyrimidine, and wherein HET may optionally be substituted with up to three substituents R 7 -R 9 individually selected from hydrogen, C 1 -C 6 alkyl; halogen; cyano, halo(C 1 -C 6 )alkyl; aryl, alkoxy and C 1 -C 6 hydroxyalkyl, -L- is a linker selected from —CH 2 —CH 2 —, —S—CH 2 —, —CH 2 —S— or —CH═CH—, R 1 is selected from hydrogen, C 1 -C 6 alkyl; C 1 -C 6 alkyl(C 3 -C 8 )cycloalkyl; C 1 -C 6 hydroxyalkyl, CH 2 CN, CH 2 C(O)NH 2 , C 1 -C 6 arylalkyl, and C 1 -C 6 alkyl-heterocycloalkyl, R 2 -R 6 are selected individually from hydrogen, C 1 -C 6 alkoxy and halogen, and tautomers and pharmaceutically acceptable acid addition salts thereof, and polymorphic forms thereof.