Patent ID: 8282396

Claim:
A method of preparing a paste for bone and tooth restoration, said method comprising the following steps: (a) formulating a composition of components by mixing in a substantially anhydrous condition: (i) a powdered calcium compound in the form of selectively sized powder particles, said particle size in the range of about 1 μm to 50 μm, said particles comprising a calcium compound selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dehydrate, octacalcium phosphate, a-tricalcium phosphate, B-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, non-stoichiometric hydroxyapatite, tetracalcium phosphate, CaSO 4 , CASO 4 .0.5H 2 O, CASO 4 .2H 2 O, CaO, Ca(OH) 2 , CaCO 3 and mixtures thereof; (ii) a carboxylic acid for accelerating hardening of said composition when said composition is exposed to water at a delivery site, said acid comprising an acid selected from the group consisting of glycolic, citric, tartaric, malonic, malic, maleic acids and combinations thereof; (ii) a non-toxic, non-aqueous water-miscible liquid; and (iii) a gelling agent; said powder to liquid mass ratio is at least about 1.5, said components blended to obtain a substantially homogeneous formable anhydrous paste mixture having a hardening time of less than about 35 minutes and a diametral tensile strength (DTS) in the range of about 2.7 to 3.8±0.3 MPa within seven days after hardening; and (b) storing said paste mixture under substantially anhydrous conditions.