Patent ID: 8409579

Claim:
A method for treating a cancer associated with expression and/or activity of FGF 19, the method comprising administering an effective amount of an anti-FGF19 antibody, comprising: (a) a light chain comprising: (i) hypervariable region (HVR)-L1 comprising sequence A1-A11, wherein A1-A11 is KASQDINSFLA (SEQ ID NO: 11); (ii) HVR-L2 comprising sequence B I-B7, wherein B1-B7 is RANRLVD (SEQ ID NO:2), RANRLVS (SEQ ID NO: 13), or RANRLVE (SEQ ID NO: 14); and (iii) HVR-L3 comprising sequence C1-C9, wherein C1-C9 is LQYDEFPLT (SEQ ID NO:3); and (b) a heavy chain comprising: (i) HVR-H1 comprising sequence D1-D10, wherein D1-D10 is GFSLTTYGVH (SEQ ID NO:4); (ii) HVR-H2 comprising sequence E1-E17, wherein E1-E17 is GVIWPGGGTDYNAAFIS (SEQ ID NO:7); and (iii) HVR-H3 comprising sequence F1-F13, wherein F1-F13 is VRKEYANLYAMDY (SEQ ID NO:8) to an individual in need of such treatment.