Patent ID: 7973060

Claim:
A compound having a formula (I) or a pharmaceutically acceptable salt, acid, or ester: wherein, R 1 is C 2-8 alkyl which contains one or more substituents selected from the group consisting of: C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, benzyloxy, aryl, heteroaryl, substituted aryl, and substituted heteroaryl, wherein said substituted aryl and substituted heteroaryl each contain one or more substituents selected from the group consisting of C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, alkyloxy, amino, alkylamino, carboxyl, nitro, sulfonylamide, alkylsulfonyl, amide, dioxoisoindole, trihaloalkyl, and aryl; A is CH; B is CH 2 ; R 4 is a substituted aryl containing one or more substituents selected from the group consisting of: hydroxyl, halogen, C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, alkyloxy, amino, alkylamino, carboxyl, nitro, sulfonylamide, alkylsulfonyl, amide, dioxoisoindole, trihaloalkyl, aryl, heteroaryl, and substituted heteroaryl, wherein said substituted aryl and substituted heteroaryl each contain one or more substituents selected from the group consisting of: C 1 - 6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, alkyloxy, amino, alkylamino, carboxyl, nitro, sulfonylamide, alkylsulfonyl, amide, dioxoisoindole, trihaloalkyl, and aryl; W is CH; Z is CH ; and X is O.