Patent ID: 7704512

Claim:
A non-cytotoxic agent for treating pain comprising a fusion protein including a botulinum neurotoxin LH N fragment and a substance P peptide, wherein the substance P peptide is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 18, or a fragment of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 18 that binds to a substance P receptor, and wherein the botulinum neurotoxin LH N fragment is a botulinum neurotoxin light chain or a functional fragment thereof coupled to a botulinum neurotoxin H N domain.