Patent ID: 8338375

Claim:
A packaged product useful for dermal correction and sculpting comprising: a syringe; and an injectable dermal filler composition in the syringe, the composition comprising a cross-linked collagen prepared by the steps of incubating collagen selected from a group consisting of type I collagen, type II collagen, type III collagen, type IV collagen, type V collagen, telo-containing collagen, atelo-collagen, derivatized collagen, and a combination thereof, in a suspension or solution having pH in the range of pH 2-5 or pH 9-12, treating said collagen with a cross-linking agent selected from the group consisting of carbodiimides, polyaldehydes, polysulfones, activated PEGs, epoxides, imidazoles and diisocyanates at pH 2-5 or pH 9-12, and isolating the cross-linked collagen to thereby obtain the composition, wherein the cross-linked collagen is in a gel but not in a fibrous state.