Patent ID: 7179918

Claim:
A compound of the Formula I-A: wherein: R 1 is a 3-, 4-, or 7-membered mono-cyclic carbocyclic group; R 2 is an aliphatic group, a carbocyclic group, a carbocyclic-aliphatic group, a heterocyclic group, or a heterocyclic-aliphatic group; R 2′ is H or a C 1 –C 6 alkyl group; or R 2 and R 2′ taken together with the nitrogen atom to which they are attached form an unsubstituted or substituted heterocyclic ring; X is wherein R x is H or one or more substituents independently selected from alkyl, nitro, amino, cyano, halogen, haloalkyl, hydroxyl, alkoxy, alkylenedioxy, alkylcarbonyl, alkyloxycarbonyl, alkylcarbonyloxy, carboxyl, carbamoyl, formyl, alkylamino, dialkylamino, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminothiocarbonyl, dialkylaminothiocarbonyl, alkylsulfonyl, alkylsulfenyl, alkylcarbonylamino, alkylthiocarbonylamino, alkylsulfonyloxy, alkylsulfonylamino, mercapto, and alkylthio; R 8 and R 8′ are each independently H, halo or a C 1 –C 4 aliphatic group; Z is CH 2 , CHF, CF 2 , CH(OH), CH(O—R Z ), CH(N—R Z R Z′ ), CH(S—R Z ), C(═O), or CH(R Z ), where R Z is a C 1 –C 6 aliphatic group or a carbocyclic or heterocyclic group and R Z′ is H or a C 1 –C 6 aliphatic group; R 3 is H or a C 1 –C 6 aliphatic group; R 4 and R 5 are independently selected from H, halo, a C 1 –C 6 aliphatic group or a group having the formula C(O)R 4′ , wherein R 4′ is an aliphatic, carbocyclic or heterocyclic group; R 6 and R 7 are independently selected from H, halo or a C 1 –C 6 aliphatic group; wherein any of said aliphatic groups are unsubstituted or substituted by one or more suitable substituents and saturated, partially unsaturated or fully unsaturated; and wherein any of said carbocyclic or heterocyclic groups are mono-, bi- or tri-cyclic saturated, partially unsaturated or fully unsaturated or unsubstituted or substituted by one or more suitable substituents; provided that R 2 is not an aliphatic group, a phenyl group or a phenyl-substituted aliphatic group, when Z is CHF or CH 2 ; R 2′ , R 3 , R 8 and R 8′ are H or a C 1 –C 4 alkyl group; R 4 , R 5 , R 6 and R 7 are H or a C 1 –C 6 alkyl group; X is and R 1 is a substituted or unsubstituted 5- or 6-membered mono-cyclic carbocyclic group; or a prodrug, pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.