Patent ID: 7329401

Claim:
A cyclooxygenase-2 selective agent having the formula: wherein: A is a 4-, 5-, or 6-membered ring selected from the group consisting of partially unsaturated heterocyclyl, heteroaryl, cycloalkenyl, and aryl; R 1 is selected from methylsulfone and sulfonamide; R 2 is-selected from heteroaryl, cycloalkyl, cycloalkenyl, and aryl; and R 3 is a linear or branched alkyl; and either: R 3 contains a radioactive or paramagnetic isotope, and R 4 is hydrogen; or R 4 is or contains a radioactive or paramagnetic isotope; and wherein the cyclooxygenase-2 selective agent is not 4-(5-[ 18 F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide or 4-(5-[ 18 F]fluoroethyl-3-phenylisoxazol-4-yl)benzenesulfonamide.