Patent ID: 8377967

Claim:
A piperidine derivative, or salt or hydrate thereof that is pharmaceutically acceptable, wherein the piperidine derivative is represented by the following general formula (I): wherein R 1 stands for a hydrogen or a substituent selected from the following (a) to (i): (a) a cyano, (b) acrylic acid, an alkyl ester of acrylic acid, or a hydroxyalkylamide of acrylic acid, (c) a ureido, (d) an alkenyl, (e) an aminoalkyl which may be substituted with an alkylcarbonyl or an aminocarbonyl, (f) a carbonylalkyl substituted with a hydroxy, an alkoxy or a hydroxyalkylamino, (g) a carbonyl substituted with a hydroxy, a morpholino, an alkoxy, a hydroxyalkylaminoalkoxy or cyclohexyloxycarbonyloxyalkoxy, (h) a carbonylamino substituted with an alkyl or an alkoxy, (i) an aminocarbonyl which may be substituted with one or two substituents selected from an amino, a hydroxy, an alkoxy, an alkenyl, and an alkyl (which may be substituted with a halogen, a thiol, a piperidino, an amino, an alkoxy, an alkoxycarbonyl, an aminocarbonyl, or one or two hydroxys); R 2 stands for a hydrogen or a substituent selected from the following (j) to (q): (j) acrylic acid, an alkylester of acrylic acid, or a hydroxyalkylamide of acrylic acid, (k) an alkyl substituted with a hydroxy or a piperidino, (l) a carbonylalkyl substituted with a hydroxy, an alkoxy (which may be substituted with a cyclohexyloxycarbonyloxy), a piperidino, or a hydroxyalkylamino, (m) a carbonyl substituted with a hydroxy, an alkoxy, or a hydroxyalkylamino, (n) a carbonylalkoxy substituted with a hydroxy or an alkoxy, (o) a carbonylalkylsulfanyl substituted with a hydroxy or an alkoxy, (p) an alkoxy, (q) a halogen; and R 3 stands for a hydrogen or a substituent selected from the following (r) to (v): (r) an alkyl which may be substituted with a carboxy, a cyano, a pyrrolidyl, a piperidino, an alkoxy, an alkylsulfanyl, or one or two hydroxys, (s) a carbonyl substituted with an alkyl or alkoxy, (t) a carbonylalkoxyalkyl substituted with a hydroxy or an alkoxy, (u) a carbonylalkyl substituted with an alkyl, an alkoxy, or an alkylphenyl, (v) an aminoalkyl substituted with an aminocarbonyl or an alkanesulfonyl, wherein one of the above R 1 and R 2 stands for a substituent other than a hydrogen, A stands for a hydrogen or an oxo, B stands for a carbon or an oxygen, one of X and Y stands for a carbon and the other is a sulfur, a broken line part stands for a single bond or a double bond, with the proviso that when R 2 stands for a halogen or an alkoxy, then A stands for a hydrogen, R 1 stands for a substituent other than a hydrogen, and B stands for an oxygen.