Patent ID: 8722681

Claim:
A thiazolyl-piperazine derivative represented by the structural formula (I) wherein: W is a single bond or CH 2 ; R 1 is a phenyl ring substituted with two or three halogens or with one or more substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy and trifluoromethyl, or any two adjacent substituents of said phenyl ring form, together with the phenyl ring carbon atoms to which they are attached, a saturated ring fused to said phenyl ring and having 5 ring members, said saturated ring comprising one or two heteroatoms independently selected from the group consisting of oxygen and nitrogen; and each of said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more halogen atoms; or R 1 is a monocyclic saturated or mono-unsaturated heterocyclyl having 5 or 6 members and comprising one or more atoms selected from the group consisting of nitrogen, oxygen, and sulfur and optionally substituted with one or more substituents independently selected from R 8 and R 9 ; or R 1 is a monocyclic polyunsaturated heterocyclyl having 5 or 6 members and comprising one or more atoms selected from the group consisting of nitrogen and oxygen and optionally substituted with one or more substituents independently selected from R 8 and R 9 ; R 2 is a phenyl ring optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, trifluoromethyl and halogen; or any two adjacent substituents of said phenyl ring form, together with the phenyl ring carbon atoms to which they are attached, a saturated ring fused to said phenyl ring and having 5 ring members, said saturated ring comprising one or two heteroatoms independently selected from the group consisting of oxygen and nitrogen; and each of said C 1-6 alkyl and C 1-6 alkoxy is optionally substituted with one or more halogen atoms, or R 2 is a monocyclic heterocyclyl having 5 or 6 members and comprising one or more atoms selected from the group consisting of nitrogen, oxygen, and sulfur and optionally substituted with one or more substituents independently selected from R 8 and R 9 , said heterocyclyl including more than one oxygen atom or including one or more heteroatoms selected from the group consisting of nitrogen and sulfur; R 3 is hydrogen; each R 8 is independently selected from the group consisting of C 1-10 alkyl and C 1-6 alkoxy; and each R 9 is independently selected from the group consisting of OH, NO 2 and halogen, or a stereoisomer thereof, or an enantiomer thereof, or a N-oxide thereof, or a pharmaceutically acceptable salt thereof, provided that said derivative is not: 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine; or 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine.