Patent ID: 8450464

Claim:
A monoclonal antibody, or an antigen-binding portion thereof, which cross-competes for binding to human CXCR4 with a reference antibody or reference antigen-binding portion thereof, wherein the reference antibody or portion thereof comprises: (a) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 25 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 29; (b) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 26 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 30; (c) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 27 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 31; or (d) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 28 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 32; and further wherein the monoclonal antibody or portion thereof comprises a heavy chain variable region comprising amino acids having a sequence derived from a human V H 3-48 germline sequence as set forth in SEQ ID NO:49 and a light chain variable region comprising amino acids having a sequence derived from a human V K L15 germline sequence as set forth in SEQ ID NO:50.