Patent ID: 7375238

Claim:
A process for the preparation of a N-(N′-substituted glycyl)-2-cyanopyrrolidine comprising at least (a) reacting, in the presence of dimethylformamide, a compound of formula (V) wherein, independently of each other, X1 and X3 are halogen; X2 is halogen, OH, O—C(═O)—CH 2 X 3 , —O—SO 2 —(C 1-8 )alkyl or —O—SO 2 -(aryl), with L-prolinamide, followed by (b) reacting the resultant compound without isolation with a dehydration agent selected from (haloalkylene)dialkylammonium halide followed by (c) reacting, in the presence of a base, the resultant compound without isolation with an appropriate amine and (d) recovering the resultant compound in free form or in acid addition salt form.