Patent ID: 7273856

Claim:
Linear compounds of general formula (I) wherein: X1 is a —CO— group; R1 is an aromatic group selected from the group consisting of biphenyl, phenyl-ethylene, naphthyl, phenyl-thiophene, benzothiophene, benzofurane, and indole possibly N-substituted by a C1–C6 alkyl group, which can be possibly substituted by one, two or three groups independently selected from the group consisting of halogen, C1–C6 alkyl possibly substituted by not more than three fluorine atoms, C1–C6 alkyloxy, OH, NHR10, and N(R10) 2 , wherein R10 is selected from H and C1–C6 alkyl; R6 is H; in the amoniacidic residue of general formula (III) A is methyl; B is selelected from the group consisting of ethyl and phenyl; or A and B are joined together and form, with the carbon atom to which they are linked, a group selected from the group consisting of cyclohexyl, cyclopentyl, indanyl, cyclopent-3-enyl; R2 is a phenyl-methyl group, having the phenyl group possibly substituted by a C1–C6 alkyl group; X2 is selected from —CONH— and CH 2 NH—; R3 includes at least one basic amino group having the following formula: —R 4 —X 3 —R 5 wherein: R4 is selected from the group consisting of a group —(CH 2 ) n — wherein n ranges from 1 to 3, a C5–C8 cycloalkylene group selected from cyclopentylene and cyclohexylene, and an aliphatic heterocycle selected from piperidine, pyrrolidine and piperazine possibly substituted by one or two C1–C6 alkyl groups; X3 is a bond or it is a group selected from —CO—, —CH 2 —, —CH 2 —CH 2 —, and —NH—CO—; R5 is selected from: a) an aliphatic heterocycle selected from the group consisting of piperidine, pyrrolidine, morpholine, diazepan, tetrahydropyran, and 1,4-dioxa-8-s7nspiro[4,5]decane, possibly substituted by one or two groups selected from C1–C6 alkyl, C1–C6 alkyloxy, OH, and cyanomethyl; b)an azetidine substituted by a group —(CH2) n —R17, wherein R17 is tetrahydropyran; c) a piperidine possibly C-substituted by a C1–C6 alkyl group, and substituted by a group X5-R18 wherein X5 is a bond or it is selected from the group consisting of —C(R11)(R12)-, —CO—, —CH 2 CH 2 —, and —COCH 2 —, and R18 is a group selected from thiophene, tetrahydropyran, tetrahydrothiopyran, pyrrolidine, cyclohexane, cyclopentane, and 1-3-dioxane, possibly substituted by one or more groups selected from C1–C6 alkyl, —NHR10, and —N(R10) 21 wherein R10, R11 and R12 are selected from H and linear or branched C1–C6 alkyl; d) a piperazine possibly C-substituted by one or two C1–C6 alkyl group, and possibly N-substituted by a group selected from —CH 2 CN and X4-R16, wherein X4 is a bond or it is selected from —CH 2 — and —COCH 2 —, and R16 is selected from the group consisting of pyridine, thiophene, tetrahydropyran, morpholine, tetrahydrofurane, and 1,3-dioxane; e) an amino group selected from —NR11R12 and —NH—(CH 2 )m-NR11R12, wherein R11, R12 and in are as defined above; f) an amino-cyclohexane or a cyclohexane possibly substituted on the ring by the group —NR11R12, wherein R11 and R12 are as defined above; g) an heteroaromatic group represented by pyridine.