Patent ID: 7531329

Claim:
An isolated polynucleotide which is the following (a), (b) or (c): (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:2, (b) a polynucleotide capable of hybridizing with a polynucleotide comprising the nucleotide sequence fully complementary to the nucleotide sequence of SEQ ID NO:2 under stringent conditions, wherein said stringent conditions comprise washing a filter with 0.1 to 2×SSC solution at 65° C., and coding for a polypeptide having activity in stereoselectively reducing N-benzyl-3-pyrrolidinone represented by the formula (1): to form (R)-N-benzyl-3-pyrrolidinol represented by the formula (2): (c) a polynucleotide having at least 90% homology to the nucleotide sequence of SEQ ID NO:2, wherein said polynucleotide encodes a polypeptide with carbonyl reductase activity.