Patent ID: 8703735

Claim:
An antisense oligonucleotide compound comprising morpholino subunits linked by phosphorous-containing intersubunit linkages, the intersubunit linkages joining a 3′ morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit in accordance with the following structure: wherein: P j and P i are, at each occurrence, independently a purine or pyrimidine base-pairing moiety effective to bind, by base-specific hydrogen bonding, to a base in a polynucleotide; and X is, at each occurrence, independently alkyl, alkoxy, thioalkoxy, a cyclic amine, or —NR 2 , wherein each R is independently H or lower alkyl, and wherein the antisense oligonucleotide compound is targeted against the Ebola virus VP24 gene and comprises a sequence having at least 90% sequence homology to the sequence set forth in SEQ ID NO:77.