Patent ID: 8859602

Claim:
The compounds of Formula I or a tautomer or pharmaceutically acceptable salt thereof, wherein: W is wherein each R 4 is independently H, F, Cl, Br, I, OH, OCH 3 , OCH 2 CH 3 , SC (1-4) alkyl, SOC (1-4) alkyl, SO 2 C (1-4) alkyl, —C (1-3) alkyl, CO 2 R d , CONR e R f , C≡CR g , or CN; wherein R d is H, or —C (1-3) alkyl; R e is H, or —C (1-3) alkyl; R f is H, or —C (1-3) alkyl; and R g is H, —CH 2 OH, or —CH 2 CH 2 OH; R 2 is cycloalkyl, spiro-substituted cycloalkenyl, or phenyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy, C (1-3) alkyl, or C (1-4) alkyl; Z is H, F, or CH 3 ; J is CH; X is wherein R 1 is —C (1-4) alkyl, —OR a , —CN, —NA 1 A 2 , —SO 2 CH 3 , —COOR a , —CO 2 CH 3 , —CH 2 —NA 1 A 2 , —CONA 1 A 2 , —CH 2 OR a , —OC (1-4) alkylOR a , —NHCH 2 CH 2 CO 2 R a , —NHCH 2 CH 2 OR a , —NR a CH 2 CH 2 NA 1 A 2 , —OC (1-4) alkylNA 1 A 2 , —OCH 2 CO 2 R a , —CH 2 CO 2 R a , —CH 2 CH 2 SO 2 C (1-4) alkyl, —SO 2 CH 2 CH 2 NA 1 A 2 , —SOCH 2 CH 2 NA 1 A 2 , —SCH 2 CH 2 NA 1 A 2 , —NHSO 2 CH 2 CH 2 NA 1 A 2 , phenyl; R z and R y are independently H or —C (1-4) alkyl, wherein both R z may have either syn or anti stereochemistry; alternatively both R z in a syn relationship may be taken together to form —(CH 2 ) n —, where n is 2 or 3; R 3 is H, C (1-4) alkyl, C (1-3) alkyl-CF 3 , CH 2 CH 2 NH 2 , CH 2 CH 2 OR a , —COCH 3 , CONH 2 , or CO 2 R a ; A 1 is H, —C (1-4) alkyl, or CH 2 CH 2 OR a ; A 2 is H, —C (1-4) alkyl, COR a , CH 2 CON(CH 3 ) 2 , —CH 2 CH 2 OR a , —CH 2 CH 2 SC (1-4) alkyl, —CH 2 CH 2 SOC (1-4) alkyl, or —CH 2 CH 2 SO 2 C (1-4) alkyl; wherein R a is H or C (1-4) alkyl.