Patent ID: 8445505

Claim:
A compound of Formula (4) or (5): or a physiologically acceptable salt thereof; wherein R 1 is halo, C 1-6 alkyl, or a halo-substituted C 1-6 alkyl; each R 3 is H; one of R 4a , R 4b and R 4c is H and the others are independently halo, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl or halo-substituted C 1-6 alkoxy; X is quinolinyl, (1,2,3,4-tetrahydroisoquinolin-6-yl) or a 5-6 membered heteroaryl selected from pyrazolyl, pyridyl, thiophenyl, furanyl, imidazolyl, isoxazolyl, oxazolyl or thiazolyl, each of which is optionally substituted with C 1-6 alkyl, hydroxyl, or C(O)NRR 7 in which R 7 is H or C 1-6 alkyl and R is H or C 1-6 alkyl; ring E is a C 6 carbocycle optionally substituted with oxo, ═N—OH or R 9 ; R 9 is hydroxyl or NRR 7 in which R 7 is C 1-6 alkyl or (CR 2 ) q Y, Y is C 3 cycloalkyl and R is H or C 1-6 alkyl, or alternatively, R and R 7 together with N in NRR 7 of R 9 forms morpholinyl, piperidinyl, piperazinyl, (C 1-6 alkyl)-piperazinyl, or pyrrolidinyl, each of which is optionally substituted with hydroxyl; and q is 0-4.