Patent ID: 8710061

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein A is a nitrile group; B is selected from phenyl and pyridinyl, wherein the phenyl and pyridinyl are optionally substituted with one or two substituents independently selected from C 1-6 alkoxy, C 1-6 alkyl, C 1-3 alkylamino-C 1-6 alkoxy, cyano, C 1-3 dialkylamino-C 1-6 alkoxy, halo, haloC 1-6 alkoxy, haloC 1-6 alkyl, hydroxy, methylamino, and amino; D is selected from the group of: “ ” denotes the point of attachment to the nitrogen atom of the parent molecule; “ ” denotes the point of attachment to the ‘E’ moiety; R a is selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl, and hydroxy; R b is —NR x R y , wherein R x and R y are independently selected from hydrogen, C 1-4 alkoxy, C 1-4 alkoxyC 1-4 alkyl, C 1-4 alkoxycarbonyl, C 1-6 alkyl, C 3-7 cycloalkyl, (C 3-7 cycloalkyl)C 1-4 alkyl, hydroxyC 1-4 alkyl, and trideuteromethyl, wherein the alkyl part of the (C 3-7 cycloalkyl)C 1-4 alkyl can be optionally substituted with a C 1-4 alkoxy group; or, R x and R y , together with the nitrogen atom to which they are attached, form a four- to seven-membered monocyclic or bicyclic ring optionally containing one double bond and optionally containing one additional heteroatom selected from O, NR Z , and S; wherein R z is selected from hydrogen, C 1-6 alkyl, and C 1-4 alkoxycarbonyl; and wherein the ring is optionally substituted with one or two substituents independently selected from C 1-6 alkoxy, C 1-6 alkyl, halo, haloC 1-4 alkyl, hydroxy, —NR f R g , oxo, spirocyclic dioxolanyl; wherein R f and R g are independently selected from hydrogen, C 1-4 alkoxycarbonyl, and C 1-6 alkyl; R c is selected from hydrogen, C 1-4 alkylsulfonyl, C 1-4 alkylsulfonylamido, amino, C 1-6 alkylamino, C 1-6 dialkylamino, C 3-7 cycloalkylamino, hydroxy, and C 1-4 alkoxy; R d is selected from hydrogen, C 1-6 alkyl, C 1-4 alkoxyC 1-4 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl, C 3-7 cycloalkylsulfonyl, C 3-7 cycloalkylcarbonyl, C 1-6 dialkylaminoC 1-4 alkylcarbonyl, and haloC 1-4 alkyl, wherein the alkyl part of the alkoxycarbonyl, the alkylcarbonyl, and the alkylsulfonyl are optionally substituted with one substituent selected from C 1-4 dialkylamino, and C 1-4 alkoxy; and E is selected from C 1-6 alkyl, C 4-6 cycloalkyl, (C 4-7 cycloalkyl)C 1-4 alkyl, benzyl, phenyl, and a five- to six-membered heteroaromatic ring containing one or two nitrogen atoms, wherein the phenyl, the phenyl part of the benzyl, and the heteroaromatic ring are each optionally substituted with one, two, or three substituents independently selected from C 1-6 alkyl, C 1-6 alkoxy, cyano, halo, halo C 1-6 alkoxy, and haloC 1-6 alkyl.