Patent ID: 8389560

Claim:
A compound of formula (I): wherein R 1 is —H, —OH, C 1-6 alkyl, C 1-6 alkoxyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, heteroaryl, —Z—R, or —NH—Z—R; in which R is H, or is a moiety selected from C 1-6 alkyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl, each of which is optionally mono-, di- or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, or heteroaryl; and Z is —C(O)—, —C(O)O—, —C(O)C(O)O—, —C(O)C(O)NH—, —C(O)NR′—, —OC(S)—, —C(S)NR′—, or —C(NH)O—, R′ being H, C 1-6 alkyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl; R 2 is H, or is a moiety selected from C 1-6 alkyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl, each of which is optionally mono-, di-, or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, or heteroaryl; A is N or CH; U is —O—, —NH—, —NH(CO)—, —NHSO—, or —NHSO 2 —; W is —(CH 2 ) m —, —NH(CH 2 ) n —, —(CH 2 ) n NH—,—O(CH 2 ) n —, —(CH 2 ) n O—, —S(CH 2 ) n —, —(CH 2 ) n S—, —SO—, —SO(CH 2 ) n —, —(CH 2 ) n SO—, —SO 2 (CH 2 ) n —, or —(CH 2 ) n SO 2 —, m being 1,2, or 3 and n being 0, 1, or 2; X is —O—, —S—, or —NH; Y is in which each of V and T, independently, is —CH— or —N—; each of A 1 and A 2 , independently, is a moiety selected from C 4-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl, each of which is optionally mono-, di-, or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, or heteroaryl, or optionally fused with C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl; and R i is H, halo, nitro, cyano, or amino, or is a moiety selected from C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl, each of C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, and C 2-6 alkynyl being optionally mono-, di- or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl, and each of C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, and heteroaryl being optionally mono-, di- or tri-substituted with halo, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl, or optionally fused with C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl; and is a single bond or a double bond.