Patent ID: 7553975

Claim:
A compound having the formula wherein: R 1 is H, lower alkyl, cycloalkylthio, or lower alkylthio; each of R 2 and R 3 , independently, is H or lower alkyl; R 4 is O; R 5 is H, or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is lower alkyl, —O—R 10 , —S(O) m R 10 (where m is 0, 1, or 2), —N(R 10 )(R 11 ), —N—C(O)—R 10 , —NH—(SO 2 )—R 10 ; —CO 2 —R 10 , —C(O)—N(R 10 )(R 11 ), or —(SO 2 )—N(R 10 )(R 11 ); R 6 is —C(O)NHCHR 13 CO 2 R 14 ; R 7 is substituted or unsubstituted aryl, wherein the substituent is OH, lower alkyl, lower alkoxy, aryloxy, aryl lower alkoxy, —N(R 10 )(R 11 ), —COOH, —C(O)—N(R 10 )(R 11 ), or halo; R 8 is H, or substituted or unsubstituted lower alkyl, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is OH, lower alkyl, lower alkoxy, —N(R 10 )(R 11 ), —COOH, —C(O)—N(R 10 )(R 11 ), or halo; or R 8 and R 9 , together, form aryl or heterocyclyl; and each of R 10 and R 11 , independently, is H, lower alkyl, aryl, aryl lower alkyl, cycloalkyl, cycloalkyl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl; R 12 is S; R 13 is substituted lower alkyl wherein the substituent is —S(O) m R 10 (wherein m is 0); and R 14 is H; or a pharmaceutically acceptable salt thereof.