Patent ID: 8273887

Claim:
A process for the preparation of a compound of Formula (III), the process comprising a first reaction that comprises contacting a compound of Formula (I) with an aprotic solvent and a dienophile to form a compound of Formula (II), and then a second reaction that comprises contacting the compound of Formula (II) with a catalyst, hydrogen, and the aprotic solvent to form a compound of Formula (III) according to the following reaction scheme: wherein: R 1 and R 8 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; R 2 and R 3 are independently selected from the group hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {—}OH, {—}NH 2 , {—}SH, {—}SR 8 , and {—}OR 8 ; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; and X is oxygen, and wherein the first reaction and the second reaction are both conducted in a one-pot process; and the aprotic solvent used for the first reaction and the aprotic solvent for the second reaction are the same.