Patent ID: 8465741

Claim:
An antibody or antigen-binding fragment thereof comprising at least one variable region having a combination of: (1) light chain BD22084 (SEQ ID NO:225) and heavy chain BD20332 (SEQ ID NO:138); (2) light chain BD22085 (SEQ ID NO:232) and heavy chain BD20335 (SEQ ID NO:143); (3) light chain BD22086 (SEQ ID NO:227) and heavy chain BD20335 SEQ ID NO:143); (4) light chain BD22088 (SEQ ID NO:229) and heavy chain BD20337 (SEQ ID NO:148); (5) light chain BD22087 (SEQ ID NO:240) and heavy chain BD20335 (SEQ ID NO:143); (6) light chain BD22089 (SEQ ID NO:243) and heavy chain BD20335 (SEQ ID NO:143); (7) light chain BD22090 (SEQ ID NO:234) and heavy chain BD20337 (SEQ ID NO:148); (8) light chain BD22095 (SEQ ID NO:244) and heavy chain BD20337 (SEQ ID NO:148); (9) light chain BD22091 (SEQ ID NO:242) and heavy chain BD20337 (SEQ ID NO:148); (10) light chain BD22108 (SEQ ID NO:230) and heavy chain BD20337 (SEQ ID NO:148); (11) light chain BD22092 (SEQ ID NO:235) and heavy chain BD20338 (SEQ ID NO:149); (12) light chain BD22094 (SEQ ID NO:231) and heavy chain BD20337 (SEQ NO: 148); (13) light chain BD22096 (SEQ ID NO:241) and heavy chain BD20337 (SEQ ID NO:148); (14) light chain BD22092 (SEQ ID NO:235) and heavy chain BD20337 (SEQ ID NO:148); (15) light chain BD22102 (SEQ ID NO:248) and heavy chain BD20337 (SEQ ID NO: 148); (16) light chain BD22097 (SEQ ID NO:246) and heavy chain BD20335 (SEQ ID NO:143); (17) light chain BD22104 (SEQ ID NO:239) and heavy chain BD20337 SEQ ID NO:148); (18) light chain BD22085 (SEQ ID NO:232) and heavy chain BD20339 (SEQ ID NO:150); (19) light chain BD22107 (SEQ ID NO:226) and heavy chain BD20339 (SEQ ID NO: 150); (20) light chain BD22100 (SEQ ID NO:236) and heavy chain BD20335 (SEQ ID NO:143); (21) light chain BD22103 (SEQ ID NO:228) and heavy chain BD20337 SEQ ID NO:148); (22) light chain BD22105 (SEQ ID NO:237) and heavy chain BD20337 (SEQ ID NO:148); (23) light chain BD22101 (SEQ ID NO:247) and heavy chain BD20335 (SEQ ID NO:143); (24) light chain BD22106 (SEQ ID NO:245) and heavy chain BD20333 (SEQ ID NO:142); (25) light chain BD22108 (SEQ ID NO:230) and heavy chain BD20338 (SEQ ID NO:149); (26) light chain BD22109 (SEQ ID NO:233) and heavy chain BD20341 (SEQ ID NO:154); or (27) light chain BD22111 (SEQ ID NO:238) and heavy chain BD20336 (SEQ ID NO:144).