Patent ID: 7763618

Claim:
A method of inhibiting human stearoyl-CoA desaturase in vitro (hSCD) activity comprising contacting a source of hSCD with a compound of formula (I): wherein: x and y are each independently 1; W is —C(O)N(R 1 )— or —N(R 1 )C(O)—; V is —C(O)—; each R 1 is independently selected from the group consisting of hydrogen, C 1 -C 12 alkyl, C 2 -C 12 hydroxyalkyl, C 4 -C 12 cycloalkylalkyl and C 7 -C 19 aralkyl; R 2 is selected from the group consisting of C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl, C 2 -C 12 alkoxyalkyl, C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, aryl, C 7 -C 19 aralkyl, C 3 -C 12 heterocyclyl, C 3 -C 12 heterocyclylalkyl, C 1 -C 12 heteroaryl, and C 3 -C 12 heteroarylalkyl; R 3 is phenyl or naphthyl; R 4 , R 5 and R 6 are each independently selected from hydrogen, fluoro, chloro, methyl, methoxy, trifluoromethyl, cyano, nitro or —N(R 13 ) 2 ; R 7 , R 7a , R 8 , R 8a , R 9 , R 9a , R 10 and R 10a are each independently selected from hydrogen or C 1 -C 3 alkyl; and each R 13 is independently selected from hydrogen or C 1 -C 6 alkyl; a stereoisomer, enantiomer or tautomer thereof, or a pharmaceutically acceptable salt thereof.