Patent ID: 8921576

Claim:
A spiroindoline compound represented by the following formula (1), a salt or solvate thereof: wherein ring A represents a nitrogen-containing 5-10 membered unsaturated heterocyclic group, R 1 and R 2 , which are the same or different, each represent a hydrogen atom, a halogen atom, a halo C 1-6 alkyl group, a C 6-10 aryl group, a cyano group, a C 1-6 alkyl group optionally having a substituent, a C 2-6 alkenyl group optionally having a substituent, —O—R 5 , —S(O) 1 —R 6 , or —CO—R 12 , wherein R 5 represents a C 1-6 alkyl group optionally having a substituent, a halo C 1-6 alkyl group, or a C 6-10 aryl group optionally having a substituent, R 6 represents a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a mono-C 1-6 alkylamino group optionally having a substituent, a di-C 1-6 alkylamino group optionally having a substituent, a mono-C 3-8 cycloalkylamino group, or a nitrogen-containing 3-7 membered saturated heterocyclic group optionally having a substituent, l represents an integer of 0 to 2, and R 12 represents a hydroxyl group, a C 1-6 alkyl group, a mono-C 1-6 alkylamino group optionally having a substituent, or a di-C 1-6 alkylamino group optionally having a substituent, R 3 represents a hydrogen atom, a C 1-6 alkyl group optionally having a substituent, —CO—R 7 , —S(O) m —R 8 , —CS—R 13 , or a group represented by the following formula (2): wherein R 7 represents a hydrogen atom, a C 1-6 alkyl group optionally having a substituent, a halo C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 1-6 alkoxy group, a C 6-10 aryl group, an amino group, a mono-C 1-6 alkylamino group optionally having a substituent, a di-C 1-6 alkylamino group, a carboxyl group, a C 1-6 alkoxycarbonyl group, a mono-C 1-6 alkylaminocarbonyl group, a di-C 1-6 alkylaminocarbonyl group, a carbamoyl group, a C 1-6 alkylcarbonyl group, a mono-C 3-8 cycloalkylamino group optionally having a substituent, a C 1-6 alkoxyamino group, or a hydroxyamino group, R 8 represents a C 1-6 alkyl group or a mono-C 1-6 alkylamino group, m represents an integer of 0 to 2, R 13 represents a mono-C 1-6 alkylamino group, and R 14 represents a C 1-6 alkoxy group or a mono-C 1-6 alkylamino group, and R 4 represents a hydrogen atom, a halogen atom, a cyano group, a C 1-6 alkyl group optionally having a substituent, —O—R 9 , —S(O) n —R 10 , or —CO—R 11 , wherein R 9 represents a C 1-6 alkyl group, a C 6-10 aryl group optionally having a substituent, or a nitrogen-containing 5-10 membered unsaturated heterocyclic group optionally having a substituent, R 10 represents a C 1-6 alkyl group optionally having a substituent, n represents an integer of 0 to 2, and R 11 represents a hydroxyl group, a C 1-6 alkoxy group, an amino group, a mono-C 1-6 alkylamino group, a di-C 1-6 alkylamino group, or a nitrogen-containing 3-7 membered saturated heterocyclic group.