Patent ID: 7956216

Claim:
A compound of formula (I): wherein R 1 is selected from CO 2 H or a carboxylic acid or carboxylate bioisostere; R 2 is selected from an amino acid side chain and a group R a —(CHR′) x -A-(CH 2 ) y — wherein A is a covalent bond or is selected from O, S, SO, SO 2 and NR 6 , R a is H, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, heteroaryl or R b where R b is and R c is selected from heteroaryl, aryl, aryl(C 2-6 alkenyl), aryl(C 2-6 alkynyl), heteroaryl(C 2-6 alkenyl) and heteroaryl(C 2-6 alkynyl), R′ is H or C 1-6 alkyl, x and y are independently 0 or an integer from 1 to 6 provided that the sum of x and y is 1 to 6; R 3 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, heteroaryl and a group R d —(CH 2 ) p —W—(CH 2 ) q — wherein W is selected from a covalent bond, O, S and NR 6 , R d is selected from H, cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl; p is an integer from 1 to 6, q is 0 or an integer from 1 to 5 provided that the sum of p and q is 1 to 6; R 4 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, cycloalkyl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, cycloalkoxy, C 1-6 alkylthio, C 2-6 alkenylthio, C 2-6 alkynylthio, cycloalkylthio, halogen, aryl, aryl(C 1-6 alkyl)-, aryl(C 2-6 alkenyl), aryl(C 2-6 alkynyl), heterocyclyl, heterocyclyl(C 1-6 alkyl)-, heterocyclyl(C 2-6 alkenyl), heterocyclyl(C 2-6 alkynyl), heteroaryl, heteroaryl(C 1-6 alkyl)-, heteroaryl(C 2-6 alkenyl) and heteroaryl(C 2-6 alkynyl); R 5 is selected from H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkyloxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 1-6 alkythio, C 2-6 alkenylthio, C 2-6 alkynylthio, CN and C(R 7 ) 3 or when R 5 is in the 2- or 5-position, R 5 and R 3 taken together may form a 5 to 10 membered ring; R 6 is selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl; each R 7 is independently selected from H and halogen; m is 0 or an integer from 1 to 6; and n is 0 or an integer from 1 to 3; wherein each alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl and heteroaryl is optionally substituted with one or more optional substituents; and pharmaceutically acceptable salts and prodrugs thereof; with the proviso that when R 1 is COOH, R 2 is C 6 H 5 —CH 2 S—CH 2 —, R 4 is 3-C 6 H 5 and R 5 is H, R 3 is not CH 3 CH 2 —.