Patent ID: 6867230

Claim:
A compound of the formula or a pharmaceutically acceptable prodrug, salt or solvate thereof wherein: R 1 and R 10 are each independently H or OH; R 2 is H or C 1 -C 6 alkyl wherein the foregoing R 2 alkyl group is optionally substituted by 1 or 2 R 4 groups; R 3 is independently selected from C 1 -C 10 aryl or 5 to 10 membered heteroaromatic, and the heteroaromatic and aryl moieties of the foregoing R 3 groups are substituted by a —CHR 9 NR 11 R 12 group and optionally substituted by 1 to 4 R 4 groups; R 4 is independently selected from, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, halo, cyano, nitro, trifluoromethyl, difluoromethyl, trifluoromethoxy, azido, hydroxy, C 1 -C 6 alkoxy, —C(O)R 5 , —C(O)OR 5 , —NR 6 C(O)OR 8 , —OC(O)R 5 , —NR 6 SO 2 R 8 , —SO 2 NR 5 R 6 , —NR 6 C(O)R 5 , —C(O)NR 5 R 6 , —NR 5 R 6 , —S(O) j (CR 6 R 7 ) m (C 6 -C 10 aryl), —S(O) j (C 1 -C 6 alkyl), —(CR 6 R 7 ) m (C 6 -C 10 aryl), —O(CR 6 R 7 ) m (C 6 -C 10 aryl), —NR 6 (CR 6 R 7 ) m (C 6 -C 10 aryl), —(CR 6 R 7 ) m (4 to 10 membered heterocyclic), —C(O)(CR 6 R 7 ) m (C 6 -C 10 aryl), and —C(O)(CR 6 R 7 ) m (4 to 10 membered heterocyclic), wherein m is an integer from 0 to 4; j is an integer from 0 to 2, and said alkyl, alkenyl, alkynyl, aryl and heterocyclic moieties of the foregoing R 4 groups are optionally substituted by 1 to 3 substituents independently selected from halo, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, —NR 6 SO 2 R 8 , —SO 2 NR 5 R 6 , —C(O)R 5 , —C(O)OR 5 , —OC(O)R 5 , —NR 6 C(O)OR 8 , —NR 6 C(O)R 5 , —C(O)NR 5 R 6 , —NR 5 R 6 , —OR 5 , C 1 -C 10 alkyl, —(CR 6 R 7 ) m (C 6 -C 10 aryl), and —(CR 6 R 7 ) m (4 to 10 membered heterocyclic), wherein m is an integer from 0 to 4; each R 5 , R 9 , R 11 , R 12 , R 13 and R 14 is independently selected from H, C 1 -C 10 alkyl, —(CR 6 R 7 ) m (C 6 -C 10 aryl), —(CR 6 R 7 ) m (C 3 -C 10 cycloalkyl), indanyl and —(CR 6 R 7 ) m (4 to 10 membered heterocyclic), wherein m is an integer from 0 to 4, and the foregoing R 5 , R 11 , R 9 and R 12 substituents, except H, are optionally substituted by 1 to 3 substituents independently selected from halo, cyano, nitro, benzyl, trifluoromethyl, trifluoromethoxy, azido, —CH 2 (C 2 -C 6 alkenyl), —C(O)R 6 , —C(O)OR 6 , —OC(O)R 6 , —NR 6 C(O)R 7 , —C(O)NR 6 R 7 , —NR 6 R 7 , hydroxy, C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; or R 11 and R 12 can be taken together to form a 4 to 7 membered heterocyclic group optionally substituted by one R 14 group; R 6 and R 7 are each independently selected from H, —C(O)(C 1 -C 6 alkyl), C 1 -C 6 alkyl or —(CH 2 ) n (C 6 -C 10 aryl) wherein n is an integer from 0 to 2, and the foregoing aryl substituents are optionally substituted by 1 to 3 substituents independently selected from halo, cyano, nitro, trifluoromethyl, trifluoromethoxy, and azido; —NR 6 R 7 can be taken together to form the following structure and R 8 is selected from the substituents provided in the definition of R 5 except R 8 is not H.