Patent ID: 8124358

Claim:
A method of screening for a compound that inhibits binding between amyloid β (Aβ) and Fcγ receptor IIb (FcγRIIb), comprising the steps of: 1) adding a test compound and Aβ or an N-terminal fragment of Aβ to: a) FcγRIIb or an FcγRIIb extracellular domain; or b) a cell expressing FcγRIIb or an FcγRIIb extracellular domain, wherein the N-terminal fragment of Aβ binds to FcγRIIb or the FcγRIIb extracellular domain; 2) measuring binding between FcγRIIb or the FcγRIIb extracellular domain and Aβ or the N-terminal fragment of Aβ; 3) determining whether the test compound reduces binding between Aβ or the N-terminal fragment of Aβ and FcγRIIb or the FcγRIIb extracellular domain in comparison with a control; and 4) selecting a test compound that inhibits binding between Aβ and FcγRIIb.