Patent ID: 8329745

Claim:
A pharmaceutical composition comprising a ghrelin O-acyltransferase (GOAT) inhibitor of structure 1: wherein: R 1 is selected from n-heptanyl, n-heptenyl, n-heptynyl, and methyl-diethylene glycol (—CH 2 OCH 2 CH 2 OCH 2 CH 3 ); R 3 -R 5 are independently selected from an electron pair, hydrogen, optionally hetero-, optionally substituted alkyl, optionally hetero-, optionally substituted alkenyl, optionally hetero-, optionally substituted alkynyl, optionally hetero-, optionally substituted aryl, and an optionally substituted heteroatom; A is selected from CH 2 , O, S, NH, and N-alkyl; G is selected from O, S, NH, and N-alkyl; X is selected from hydroxyl, amino, alkylamino, and alkylthio; Y is C; and Z is selected from CH 2 , O, S, NH and N-alkyl, or a pharmaceutically acceptable salt thereof, wherein said inhibitor inhibits said ghrelin O-acyltransferase (GOAT), and said composition is suitable for pharmaceutical use, wherein R 2 is optionally-substituted, lower (C1-C5) alkyl.