Patent ID: 7563782

Claim:
A method of treating renal injury, the method comprising: administering to a human patient in need thereof, an effective amount of a T-type calcium channel blocker, and a pharmaceutically acceptable excipient, wherein the T-type calcium channel blocker is an optically active 1,4-dihydropyridine compound or a pharmaceutically acceptable salt thereof, of formula (1) wherein: R 1 and R 2 are independently of each other a C 1-6 alkyl group, or R 1 and R 2 together form —CR 5 R 6 —CR 7 R 8 —CR 9 R 10 —, wherein: R 5 to R 10 are independently of each other a hydrogen atom or a C 1-6 alkyl group; X 1 and X 2 are O; Ar is a phenyl group that is unsubstituted or is substituted with one or two substituents selected from the group consisting of NO 2 , CF 3 , Cl, and OR 14 , wherein R 14 is a C 1-6 alkyl group; R a and R b are independently of each other a C 1-6 alkyl group, or CH 2 O—L 2 —NR 16 R 17 , wherein R 16 and R 17 are a hydrogen atom, and L 2 is a C 2-6 alkylene group; Y is: a C 1-20 alkyl group, —L 3 —NR 18 R 19 , wherein: R 18 and R 19 are independently of each other a phenyl group, or a C 1-6 alkyl group that is unsubstituted or is substituted with a phenyl group, L 3 is a C 2-6 alkylene group, and q is 2 or 3; and * is an absolute configuration of R.