Patent ID: 8569512

Claim:
A compound of structural formula III and VII: or pharmaceutically acceptable salts and individual enantiomers and diastereomers thereof wherein: R 2 represents H, C 1-6 alkyl, CF 3 , OH; R 3 is selected from the group consisting of (CHR Y ) n pyridyl, (CHR Y ) n oxidopyridyl, (CHR Y ) n pyrimidinyl, (CHR Y ) n triazolyl, (CHR Y ) n phenyl, (CHR Y ) n pyrazinyl, (CHR Y ) n pyrazolyl, (CHR Y ) n oxadiazolyl, (CHR Y ) n thiazolyl, (CHR Y ) n thiadiazolyl, (CHR Y ) n indazopyridyl, C 1-6 alkyl, and (CHR Y ) n C 3-6 cycloalkyl, wherein R Y represents H, C 1-6 alkyl optionally substituted with R a , CF 3 , or OH or R 2 and R 3 can be combined with the nitrogen to which they are attached to form a C 5-10 heterocyclyl optionally substituted with 1 to 3 groups of R a ; R 6 represents hydrogen, OR 2 , (CH 2 ) n CF 3 , halogen, C(R 2 ) 2 OR 2 , C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocyclyl, said alkyl, cycloalkyl, aryl and heterocyclyl optionally substituted with 1 to 3 groups of R a ; R 6a is R 6 ; R a represents C 1-6 alkyl, halogen, hydroxyl, OR 2 (CH 2 ) n CF 3 , —O—, C 3-6 cycloalkyl, NR 2 C(O)R 2 , C(O)N(R 2 ) 2 , C(R 2 ) 2 OR 2 , C(O)R 2 , O(CH 2 ) n C(O)N(R 2 ) 2 , O(CH 2 ) n C(O)OR 2 , C(O)C 5-10 heterocyclyl, NO 2 , CN, N(R 2 ) 2 , C(O)OR 2 , SO 2 R 2 , OR 2 , (CH 2 ) n C 5-10 heterocyclyl, or (CH 2 ) n C 6-10 aryl, said alkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of C 1-6 alkyl, halogen, hydroxyl, (CH 2 ) n CF 3 , or CN; and n represents 0 to 4.