Patent ID: 8410434

Claim:
A liquid chromatography interface system comprising: an integrated column/electrospray ionization (ESI) tip assembly including, a liquid chromatography separation column, an ESI tip for generating ions having at least one emitting channel with an internal size less than or equal to 30 microns, and a temperature-controlled enclosure enclosing the liquid chromatography separation column; said enclosure having at least one opening and said ESI tip exposed outside the enclosure through said at least one opening; said enclosure having a heating or cooling device providing a substantially homogeneous distribution of temperature throughout an internal space of the enclosure where the liquid chromatography separation column is disposed; said enclosure including at least one gas flow mixing element to permit heat exchange by directing a flow of gas toward the ESI tip, wherein the integrated column/ESI tip assembly resides within a thermo-stabilized volume of substantially the same temperature from an entrance of the liquid chromatography separation column to an end of the ESI tip.