Patent ID: 8048892

Claim:
A compound of Formula I: a pharmaceutically acceptable salt thereof, and mixtures of any of the foregoing, wherein: n is 1; each R 1 is independently chosen from H, lower alkyl or substituted lower alkyl; R 2 is chosen from H, lower alkyl and substituted lower alkyl; R 3 and R 4 are independently chosen from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R 3 and R 4 can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring; R 5 is chosen from OH, SH, NH 2 , lower alkyl, substituted lower alkyl, lower alkoxy, substituted lower alkoxy or sulfanyl; R 6 is OH; each of R 7 , R 8 , and R 9 is independently chosen from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, NR 3a R 4a , C(O)OH, OR 12a , SR 12a , SO 2 R 12 , CN, NO 2 , halo, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclo, substituted heterocyclo, heterocycloalkyl, substituted heterocycloalkyl, alkoxycarbonyl, substituted alkoxycarbonyl, or —X—R 11 , wherein: R 3a and R 4a are independently chosen from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R 3a and R 4a can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring; X is chosen from —N(R 10 )—Y— and —Y—N(R 10 )—; Y is chosen from C(O), SO 2 , alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, and substituted alkynylene; R 10 is chosen from H, lower alkyl, and substituted lower alkyl, R 11 is chosen from H, heterocyclo, substituted heterocyclo, aryl, substituted aryl, heteroaryl and substituted heteroaryl; R 12 is chosen from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl or NR 3a R 4a ; and R 12a is chosen from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl; wherein optionally at least one of adjacent pairs R 6 and R 7 , R 7 and R 8 , R 8 and R 9 , and R 9 and R 1 , join together to form a 4 to 7 membered ring or a substituted 4 to 7 membered ring; and further wherein R 3 and R 4 are not both H.