Patent ID: 8546389

Claim:
A compound of formula (I), salts, N-oxides, solvates, hydrates, racemates, or enantiomers thereof: Z 1 and Z 2 are each independently selected from C—H, C-halo, C—C 1-4 alkyl, C—C 1-4 alkylhalo, C—C 1-4 alkoxy, C—C 1-4 alkoxyhalo and N; R 1 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, halo, C 1-4 alkylhalo, C 1-4 alkoxyhalo, C 3-7 cycloalkyl, C 3-7 cycloalkenyl, 5-6-membered heterocyclyl and 5-6 membered heteroaryl and wherein alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl and heteroaryl in each occurrence may be optionally substituted; R 2 is selected from halo, C 1-6 alkyl, C 2-6 alkenyl, NO 2 , N(R 5 ) 2 , NR 5 R 6 , NR 6 (SO 2 R 5 ), SO 2 N(R 8 ) 2 , SR 8 , C(R 5 ) 2 SO 2 R 8 , and NR 5 C(═O)R 8 ; R 3 is selected from aryl, aryl-X-aryl, aryl-X-heteroaryl, heteroaryl, heteroaryl-X-heteroaryl, and heteroaryl-X-aryl wherein X is [C(R 5 ) 2 ] p , O, S, S(═O), SO 2 , NR 5 , C═O, CF 2 , C(═O)NR 5 or NR 5 C(═O) wherein p is 1, 2 or 3 and wherein aryl and heteroaryl in each occurrence may be optionally substituted; R 4 is H, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, or C 3-7 cycloalkyl; R 5 in each occurrence is independently H or optionally substituted C 1-6 alkyl; R 6 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylhalo, C 1-6 alkoxyhalo, R 8 , C 1-6 alkyl-R 8 , C 1-6 alkyl-OR 8 , C 1-6 alkyl-SR 8 , C 1-6 alkyl-S(═O)R 8 , C 1-6 alkyl-SO 2 R 8 , C 1-6 alkyl-N(R 8 ) 2 , C 1-6 alkyl-C(═O)-R 8 , C 1-6 alkyl-O(C═O)—R 8 , C 1-6 alkyl-C(═O)O—R 8 , C 1-6 alkyl-C(═O)N(R 8 ) 2 , C 1-6 alkyl-NR 5 C(═O)—R 8 , C 1-6 alkyl-NR 5 SO 2 —R 8 , C 1-6 alkyl-SO 2 NR 5 —R 8 and C 1-6 alkyl-C(═O)NR 5 SO 2 R 8 and wherein alkyl, alkenyl, alkynyl, alkoxy, aryl, cycloalkyl, heterocyclyl and heteroaryl in each occurrence of R 6 may be optionally substituted; R 8 in each occurrence is independently H, an optionally substituted C 1-6 alkyl, an optionally substituted C 2-6 alkenyl, an optionally substituted (C 1-6 alkyl) q -aryl, an optionally substituted (C 1-6 alkyl) q -C 3-7 cycloalkyl, an optionally substituted (C 1-6 alkyl) q -5-6-membered heterocyclyl or an optionally substituted (C 1-6 alkyl) q -5-6-membered heteroaryl; and q is 0 or 1.