Patent ID: 8642580

Claim:
A method of treating a mammal suffering from a neoplastic disease state, the neoplastic disease state selected from the group consisting of colon cancer and leukemia, which method comprises administering to said mammal an acryloyl distamycin derivative, N-(5-{[(5-{[(5-{[(2-{[amino(imino)methyl]amino}ethyl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)amino]carbonyl}-1-methyl-1H-pyrrol-3-yl)-4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carboxamide hydrochloride, optionally in the form of a pharmaceutically acceptable salt, at a concentration of about 0.26 mg/kg/day to about 0.4 mg/kg/day; and cisplatin at a concentration of about 2.0 mg/kg/day to about 5.9 mg/kg/day, in amounts effective to produce a synergistic antineoplastic effect.