Patent ID: 8119628

Claim:
A compound of formula I R 1 is CO 2 R 7 or CONR 8 R 9 ; R 2 is hydrogen or alkyl; R 3 is hydrogen or alkyl; or NR 2 R 3 taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl, and is substituted with 0-3 alkyl substituents; or NR 2 R 3 taken together is R 4 is hydrogen, alkyl, alkylCO, (R 13 )alkyl, ((R 13 )alkyl)CO, (R 13 )CO, (R 13 )COCO, (Ar 1 )alkyl, (Ar 1 )CO, or (Ar 1 )COCO; R 5 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 6 is cycloalkyl; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 ,(R 10 )(R 11 )NSO 2 , or(R 12 )SO 2 ; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; R 11 is hydrogen or alkyl; R 12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; R 13 is amino, alkylamino, or dialkylamino, or R 13 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl, and is substituted with 0-3 alkyl substituents; R 14 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl; and Ar 1 is phenyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl, and is substituted with 0-2 alkyl substituents; or a pharmaceutically acceptable salt thereof.