Patent ID: 6984661

Claim:
Compound of the structural formula I: and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen. C 1 -C 8 alkyl, substituted C 1 -C 8 alkyl, aryl-C 0-4 -alkyl, substituted aryl-C 0-4 -alkyl, C 3 -C 6 cycloalkyl, substituted C 3 -C 6 cycloalkyl, heteroaryl-C 0-4 -alkyl, substituted heteroaryl-C 0-4 -alkyl, C 3 -C 6 cycloheteroalkylaryl-C 0-2 -alkyl, substituted C 3 -C 6 cycloheteroalkylaryl-C 0-2 -alkyl, C 3 -C 6 cycloalkylaryl-C 0-2 -alkyl and substituted C 3 -C 6 cycloalkylaryl-C 0-2 -alkyl; wherein the substituents for said substituted alkyl, arylalkyl, cycloalkyl, heteroarylalkyl, cycloheteroalkylarylalkyl, and cycloalkylarylalkyl are from one to three substituents each independently selected from R1′: (b) R1′, R3′, and R4′ are each independently selected from the group consisting of H, C1-C5 alkyl, C1-C5 alkoxy, C1-C5 haloalkyl, C1-C5 haloalkoxy, nitro, cyano, CHO, hydroxyl, arylC 0 -C5 5 alkoxy, arylC 0 -C5 5 alkyl, alkylcarboxamido and COOH; (c) Y is C, O, S, NH or a single bond; (d) m is 0, 1, or 2; and (e) R21 is selected from the group consisting of phenyl, substituted phenyl, and C 1 -C 6 alkyl.