Patent ID: 7115740

Claim:
A compound of formula wherein R 1 is selected from the group consisting of —H, —(CH 2 ) n -heterocycle, -lower alkyl substituted by up to three groups selected from —OR 9 , —COR 10 , —CO 2 R 10 , —CONR 10 R 11 , —SO 2 NR 10 R 11 , SO 2 R 10 or —CN; -alkyl, -cycloalkyl, -alkenyl, and -alkynyl, where n is 0, 1, 2, or 3, and the heterocycle, cycloalkyl, alkenyl, and alkynyl groups are each independently, optionally substituted by up to 3 groups selected from —OR 9 , —COR 10 , —CO 2 R 10 , —CONR 10 R 11 , —SO 2 NR 10 R 11 , —SO 2 R 10 , and —CN; R 2 and R 3 are independently selected from the group consisting of —H, —OR 9 , -halogen, —COR 10 , —(CH 2 ) n -heterocycle, -alkyl, -cycloalkyl, -alkenyl, and -alkynyl, where n is 0, 1, 2, or 3, and the heterocycle, alkyl, cycloalkyl, alkenyl, and alkynyl groups are each independently, optionally substituted by up to 3 groups selected from —OR 9 , -halogen, —COR 10 , and —CO 2 R 10 ; R 4 , R 5 , R 6 , R 7 and R 8 are each independently selected from the group consisting of —H, -lower alkyl that optionally may be substituted by hydroxy or alkoxy, —OR 12 , -halogen, —COR 13 , and —CO 2 R 13 ; R 9 is selected from the group consisting of —H, —COR 10 , -lower alkyl that optionally may be substituted by hydroxy or alkoxy, -cycloalkyl that optionally may be substituted by hydroxy, alkoxy, and lower alkyl, and -heterocycle that optionally may be substituted by hydroxy, alkoxy or lower alkyl; R 10 and R 11 are each independently selected from the group consisting of —H, -lower alkyl that optionally may be substituted by hydroxy or alkoxy, -cycloalkyl that optionally may be substituted by hydroxy, alkoxy or lower alkyl, and -heterocycle that optionally may be substituted by hydroxy, alkoxy or lower alkyl; R 12 is selected from the group consisting of —H, lower alkyl and —COR 13 ; and R 13 is selected from the group consisting of —H and lower alkyl; or the pharmaceutically acceptable salts thereof.