Patent ID: 8715666

Claim:
A method for treating pain in a subject in need thereof comprising administering to said patient: a therapeutically effective amount of an anti-TrkA antibody, wherein the variable region of the antibody light chain comprises all three complementarity determining regions (CDRs) having a sequence selected from aa. 24 to aa. 33 of SEQ ID NO: 1; from aa. 49 to aa. 55 of SEQ ID NO: 1; and from aa. 88 to aa. 96 of SEQ ID NO: 1, and wherein the variable region of the antibody heavy chain comprises all three complementarity determining regions (CDRs) having a sequence selected from aa. 26 to aa. 35 of SEQ ID NO: 2; from aa. 50 to aa. 66 of SEQ ID NO: 2; from aa. 99 to aa. 112 of SEQ ID NO: 2; and variants of the sequence from aa. 99 to aa. 112 of SEQ ID NO: 2; wherein the antibody is capable of inhibiting the binding between NGF and TrkA; and at least one analgesic opioid; thereby treating and/or preventing pain in said subject.