Patent ID: 8318735

Claim:
A compound having the formula: or a pharmaceutically acceptable salt, ester, prodrug or stereoisomer thereof, wherein the dashed line indicates an optional and additional bond, and wherein: R 1 is nitrogen-containing heteroaryl, nitrogen-containing heterocyclyl, nitrogen-containing benzofused heteroaryl or nitrogen-containing benzofused heterocyclyl, wherein R 1 is joined to the rest of the compound of formula (I) via a ring nitrogen atom, and wherein one or more ring carbon atoms of the nitrogen-containing heteroaryl, nitrogen-containing heterocyclyl, nitrogen-containing benzofused heteroaryl or nitrogen-containing benzofused heterocyclyl group can be substituted with up to 5 substituents, which may be the same or different, and are independently selected from alkyl, aryl, halo, —OH, —O-alkyl, —O-aryl, —N(R 8 ) 2 —CF 3 , —NO 2 , —C(O)R 8 , —C(O)OR 8 , —C(O)N(R 8 ) 2 , —OC(O)R 8 or —NHC(O)R 8 ; R 2 is —H, -alkyl, —NH 2 or —CH 2 NH 2 ; R 3 is —H, -alkyl, —NH 2 or —CH 2 NH 2 ; each occurrence of R 4 is independently —H, -alkyl, —NH 2 , —OH, -alkylene-OH, —CH 2 NH 2 , —C(O)R 5 , —C(O)NH 2 , —C(O)NH-alkyl, —C(O)N(alkyl) 2 , —NHC(O)R 6 or —NHS(O) 2 R 6 ; R 5 is —H, -alkyl, -aryl, -heteroaryl, —NHOH; R 6 is —H, -alkyl or —CF 3 ; R 7 is —H, —OH, —C 1 -C 6 alkyl, —O—(C 1 -C 6 alkyl), or —CF 3 ; R 8 is —H, alkyl, aryl, heterocyclyl, heteroaryl or cycloalkyl; Ar is -arylene- or -heteroarylene-, wherein the arylene or heteroarylene is joined via 2 of its adjacent ring carbon atoms, and wherein the -arylene- or -heteroarylene- can be substituted with up to 4 substituents, which may be the same or different, and are independently selected from -halo, alkyl, alkoxy, aryloxy, —SR 8 , —S(O)R 8 , —S(O) 2 R 8 , —C(O)R 8 , —C(O)OR 8 , —C(O)N(R 8 ) 2 , —NHC(O)R 8 , —CF 3 , —CN or NO 2 , and such that when Ar is tetrahydronaphthylene, R 1 and R 2 cannot both be hydrogen W is —NH— or —C(R 4 ) 2 —, wherein both R 4 groups and the carbon atom to which they are attached can combine to form a five to seven membered heterocyclyl or heteroaryl group; Y is —H, -halo, -alkyl or —CN; and Z is —CR 7 — or —N—, when the optional additional bond is absent, and —C— when the optional additional bond is present.