Patent ID: 8691819

Claim:
A compound having the following general formula (I): wherein A is —(CHR 7 )—; wherein R 7 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl, or optionally substituted heterocycloalkylalkyl; B and E are the same or different and independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl, and wherein B and E do not form an optionally substituted spiro ring indicated by dashed lines; G is —NH—, —NR 6 —, —O—, —CH 2 —, —CHR 6 — or —C(R 6 ) 2 —; wherein each R 6 is the same or different and independently selected from optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl; R l is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl, or optionally substituted heterocycloalkylalkyl; R 2 is —W 21 —W 22 —Rb—R 20 ; wherein W 21 is —(CO)— or —(SO 2 )—; W 22 is bond, —O—, —NH— or optionally substituted lower alkylene; Rb is bond or optionally substituted lower alkylene; and R 20 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, or optionally substituted heterocycloalkyl; and R 3 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl; with the proviso that 1) when Rb is optionally substituted lower alkylene, then W 22 should be —O— or —NH—, 2) when E and B are hydrogen, then R 3 should be hydrogen, 3) when G is —NH—, —CH 2 —, —CHR 6 — or —NR 6 —, then neither B nor E should be hydrogen, and 4) when G is —O—, B and E are hydrogen and R 3 is hydrogen, then R 1 should not be 8-quinolylmethyl; or a pharmaceutically acceptable salt thereof.