Patent ID: 7659297

Claim:
Compounds of general formula (I), in which R 1 and R 2 , independently of one another, mean a hydrogen atom, a hydroxy group, a halogen atom, an optionally substituted (C 1 -C 10 )-alkyl group, an optionally substituted (C 1 -C 10 )-alkoxy group, a (C 1 -C 10 )-alkylthio group, a (C 1 -C 5 )-perfluoroalkyl group, a cyano group, a nitro group, or R 1 and R 2 together mean —O—(CH 2 ) n —O—, —O—(CH 2 ) n —CH 2 —, —O—CH═CH—, —(CH 2 ) n+2 —, —NH—(CH 2 ) n+1 , —N(C 1 -C 3 -alkyl)-(CH 2 ) n+1 , and —NH—N═CH—, wherein n=1 or 2, and the terminal oxygen atoms and/or carbon atoms and/or nitrogen atoms are linked to directly adjacent ring-carbon atoms, or NR 8 R 9 , R 8 and R 9 , independently of one another, mean hydrogen, C 1 -C 5 -alkyl or (CO)—C 1 -C 5 -alkyl, R 11 means a hydrogen atom, a hydroxy group, a halogen atom, a cyano group, an optionally substituted (C 1 -C 10 )-alkyl group, a (C 1 -C 10 )-alkoxy group, a (C 1 -C 10 )-alkylthio group, or a (C 1 -C 5 )-perfluoroalkyl group, R 12 means a hydrogen atom, a hydroxy group, a halogen atom, a cyano group, an optionally substituted (C 1 -C 10 )-alkyl group, or a (C 1 -C 10 )-alkoxy group, R 3 is indazole that is optionally substituted, independently of one another, by one or more (C 1 -C 5 )-alkyl groups, which are optionally substituted by 1-3 hydroxy or 1-3 COOR 13 groups, wherein R 13 means hydrogen or (C 1 -C 5 )-alkyl, (C 1 -C 5 )-alkoxy groups, halogen atoms, hydroxy groups, NR 8 R 9 groups, exomethylene groups, or oxygen, wherein this group is linked via any position to the amine of the tetrahydronaphthalene system and optionally is hydrogenated at one or more sites, R 4 means a hydroxy group, a group OR 10 or an O(CO)R 10 group, whereby R 10 means a hydroxy protective group or a C 1 -C 10 -alkyl group, R 5 means a (C 1 -C 10 )-alkyl group or an optionally partially or completely fluorinated (C 1 -C 10 )-alkyl group, a (C 3 -C 7 )cycloalkyl group, a (C 1 -C 8 )alkyl(C 3 -C 7 )cycloalkyl group, a (C 2 -C 8 )alkenyl(C 3 -C 7 )cycloalkyl group, a heterocyclyl group, a (C 1 -C 8 )alkylheterocyclyl group, a (C 2 -C 8 )-alkenylheterocyclyl group, an aryl group, a (C 1 -C 8 )alkylaryl group, a (C 2 -C 8 )alkenylaryl group, (C 2 -C 8 )alkinylaryl groups, a monocyclic or bicyclic heteroaryl group that optionally is substituted by 1-2 keto groups, 1-2 (C 1 -C 5 )-alkyl groups, 1-2 (C 1 -C 5 )-alkoxy groups, 1-3 halogen atoms, or 1-2 exomethylene groups and that contains 1-3 nitrogen atoms and/or 1-2 oxygen atoms and/or 1-2 sulfur atoms, a (C 1 -C 8 )alkenylheteroaryl group or a (C 2 -C 8 )alkenylheteroaryl group, or a (C 2 -C 8 )alkinylheteroaryl group, wherein this group is linked via any position to the tetrahydronaphthalene system and optionally is hydrogenated at one or more sites, and R 6 and R 7 , independently of one another, mean a hydrogen atom, a methyl or ethyl group or, together with the carbon atom of the tetrahydronaphthalene system, a (C 3 -C 6 )-cycloalkyl ring.