Patent ID: 7041668

Claim:
A compound of formula (I) wherein A is phenyl or napthyl; R 1 is one or more groups selected from: NH 2 ; NH-alkyl or NH-cycloalkyl optionally substituted by acyl, acyl derivative, hydroxy, amino, alkoxy, heterocyclyl chosen from substituted or unsubstituted tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, 2-oxo-pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl or azepanyl, or aryl; or 1-imidazolyl; R 2 is: —CO-alkyl or —CO-cycloalkyl wherein said —CO-alkyl or —CO-cycloalkyl is optionally substituted by one or more amino, acyl, acyl derivative, alkoxy, aryl, OH, aminoalkyl, aminoalkylamino, hydroxyalkoxy, alkyl, arylalkyl, arylamino or aryloxy; —CO-aralkyl optionally substituted by one or more similar or different groups selected from alkoxy, halogen, amino, acyl, acyl derivative, alkyl, hydroxyalkyl, mono or dialkylamino, arylamino, nitro, perfluoroalkyl, perfluroralkoxy, perfluoroalkylthio, or alkylthio optionally substituted by amino, acyl, acyl derivative, alkyl, arylalkyl or aryl; —CO-aryl optionally substituted by one or more similar or different groups selected from halogen, alkoxy, alkyl, hydroxyalkyl, alkylthio, amino, mono or dialkylamino, heterocyclylamino, arylamino, nitro, perfluoroalkyl, perfluoroalkoxy, perfluoroalkylthio, or acyl; —CO-alkoxy optionally substituted by aryl, amino, acyl, acyl derivative, alkyl, arylalkyl or aryl; —CO-amino, —CO—NHR 3 , —CO—NR 3 R 4 wherein R 3 and R 4 are selected independently from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, fluoroalkyl, alkynyl, heterocyclyl selected from pyrrolidinylalkyl, 2-oxo-pyrrolidinylalkyl, piperidinylalkyl, tetrahydropyranylalkyl or morpholinylalkyl, alkylheterocycloalkyl selected from 4-alkylpiperazinylalkyl or N-alkyl-pyrrolidinylalkyl, aryl, aralkyl, or together form an alkylene chain optionally containing one to 4 heteroatoms selected from azetidine, pyrrolidine or piperidine, and optionally substituted by one or more amino, aminoalkyl, aminoalkylamino, hydroxy, alkoxy, hydroxyalkoxy, hydroxyalkylamino, halogen, acyl, acyl derivative, alkyl, arylalkyl, arylamino, aryloxy or aryl; or aryl or aralkyl optionally substituted by one or more similar or different groups selected from heterocyclyl selected from morpholinyl or alkyl piperazinyl, alkyl, aryl, alkoxy, amino, fluoroalkyl, acyl derivative, halogen, hydroxyalkyl, mono or dialkylamino, arylamino, heteroaryl selected from oxadiazolyl, nitro, perfluoroalkyl, perfluroroalkoxy, perfluoroalkylthio, or alkylthio optionally substituted by amino, acyl, acyl derivative, alkyl, arylalkyl or aryl; wherein when A is phenyl and R 1 is NH 2 , NH-alkyl, NH-cycloalkyl or 1-imidazolyl, said phenyl is substituted at the 4-position with said R 1 ; and when R 2 is —CO-alkoxy, R 1 is NH-cycloalkyl, or a pharmaceutically acceptable salt thereof.