Patent ID: 7777042

Claim:
A compound having the general structure shown in formula I: wherein: R is an aryl selected from the group consisting of phenyl and naphthyl; R 1 is hydrogen or C 1-6 alkyl; R 2 is CONHR 4 ; R 3 is selected from the group consisting of phenyl, phenyl C 1-4 alkyl, indolyl, indolyl C 1-4 alkyl, thiophenyl and thiophenyl C 1-4 alkyl; X is NR 10 ; wherein: R 4 is selected from the group consisting of hydrogen, C 1-10 alkyl, C 3-8 cycloalkyl, hydroxy C 2-20 alkyl, C 1-6 alkoxy-C 2-20 alkyl, aryl, aryl C 1-10 alkyl, wherein the aryl group is selected from phenyl, biphenyl, naphthyl, heteroaryl and heteroaryl C 1-10 alkyl, wherein said heteroaryl is selected from thiophenyl, heterocycloalkyl or heterocycloalkyl C 1-10 alkyl wherein heterocycloalkyl is selected from tetrahydrofuranyl, tetrahydropyranyl, alkyl or unsubstituted piperidinyl, (CH 2 ) n piperazinyl wherein n is 1 or 2, amino, and wherein: the aryl groups of R are optionally substituted with one or more substituents selected from the group consisting of fluorine, chlorine, bromine, C 1-20 alkyl or fluoroalkyl of the formula C n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and the sum of x and y is 2n+1, C 1-20 alkoxy, C 1-20 alkenyloxy, hydroxy C 1-20 alkyl, wherein: the groups of R 3 are optionally substituted with one or more substituents selected from the following: C 3-8 cycloalkyloxy, C 1-10 alkoxy, C 1-10 alkyl, C 3-10 alkenyloxy, di-(C 1-6 alkyl)amino-C 2-6 -alkyloxy, amino-C 2-6 alkyloxy, CF 3 , fluoro-propoxy, C 1-6 -alkoxy-C 2-6 -alkoxy, benzyloxy, cyclopentyloxy, hydroxy, chloro, fluoro, bromo, hydroxy-C 1-10 alkyl, C 1-6 alkyloxo, cyano, amino, benzoyl, C 1-6 alkyloxoamino, dialkylamino-C 1-10 alkyloxy, monoalkylamino-C 1-10 alkyloxy, and amino-C 1-10 alkyloxy; wherein: the aryl or heteroaryl groups of R 4 are optionally substituted with one or more substituents selected from the following: mono- or di-(C 1-6 alkyl)amino, amino, C 1-20 alkoxy, chloro, fluoro, bromo, C 1-10 alkyl, and morpholinyl; and R 10 is H, or C 1-6 alkyl or a pharmaceutically acceptable salt thereof.