Patent ID: 7569586

Claim:
A compound of formula I: wherein W represents O; R 1 is (2-9C)heteroaryl containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen and sulfur or (3-7C)cycloalkyl; wherein the heteroaryl or cycloalkyl group is unsubstituted or substituted with from 1 to 3 substituents independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C) cycloalkyl, (6-10C)aryl, (2-9C)heteroaryl, (3-5C)heterocyclic, cyano, halo, —OR 1a , —C(O)OR 1b , —SR 1c , —S(O)R 1d , —S(O) 2 R 1e , —NR 1f R 1g , —C(O)R 1h , —NR 1i C(O)OR 1j , —OC(O)NR 1k R 1l , —NR 1m C(O)R 1n , —C(O)NR 1o R 1p and —NHS(O) 2 R 1q ; where each of R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 1g , R 1h , R 1i , R 1j , R 1k , R 1l , R 1m , R 1n , R 1o , R 1p and R 1q is independently selected from hydrogen, (1-4C)alkyl or phenyl-(1-4C)alkyl; and where each (3-6C)cycloalkyl, (6-10C)aryl, (2-9C)heteroaryl and (3-5C)heterocyclic group is unsubstituted or substituted with from 1 to 3 substituents selected from (1-4C)alkyl, halo and —OR 1a ; and where each alkyl group present in R 1 is unsubstituted or substituted with from 1 to 3 fluoro substituents; each R 2 is independently selected from halo; each R 3 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 3a , —C(O)OR 3b , —SR 3c , —S(O)R 3d , —S(O) 2 R 3e and —NR 3f R 3g ; or two R 3 groups are joined to form (1-3C)alkylene, (2-3C)alkenylene or oxiran-2,3-diyl; where each of R 3a , R 3b , R 3c , R 3d , R 3e , R 3f and R 3g is independently selected from hydrogen, (1-4C)alkyl or phenyl-(1-4C)alkyl; R 4 represents a divalent hydrocarbon group containing from 4 to 28 carbon atoms and optionally containing from 1 to 10 heteroatoms selected independently from halo, oxygen, nitrogen and sulfur, provided that the number of contiguous atoms in the shortest chain between the two nitrogen atoms to which R 4 is attached is in the range of from 4 to 16; R 5 represents hydrogen or (1-4C)alkyl; R 6 is —N(R 6a )C(O)R 6b or —CR 6c R 6d OR 6e and R 7 is hydrogen; or R 6 and R 7 together form —N(R 7a )C(O)C(R 7b )═C(R 7c )—, —C(R 7d )═C(R 7c )C(O)N(R 7f )—, —N(R 7g )C(O)CR 7h R 7i —CR 7j R 7k — or —CR 7l R 7m —CR 7n R 7o C(O)—N(R 7p )—; where each of R 6a , R 6b , R 6c , R 6d and R 6e is independently selected from hydrogen and (1-4C)alkyl; and each of R 7a , R 7b , R 7c , R 7d , R 7e , R 7f , R 7g , R 7h , R 7i , R 7j , R 7k , R 7l , R 7m , R 7n , R 7o and R 7p is independently selected from hydrogen and (1-4C)alkyl; each R 8a and R 8b is independently selected from hydrogen, (1-4C)alkyl, hydroxy and fluoro, or R 8a and R 8b together with the atoms to which they are attached form a (3-6C)cycloalkyl ring or a (2-5C)heterocyclic ring containing 1 or 2 heteroatoms independently selected from oxygen, nitrogen and sulfur; a is 0 or an integer of from 1 to 3; b is 0 or an integer of from 1 to 5; c is 0 or an integer of from 1 to 4; m is 2; or a pharmaceutically acceptable salt or solvate or stereoisomer thereof.