Patent ID: 7465742

Claim:
A compound of Formula I wherein A is S, O, or N(CH 3 ); R 1 and R 2 are, independently, H, CH 3 , CF 3 , or CH 3 O; R 3 is H; or R 3 is a 5- or 6-membered ring, said ring optionally containing one or more double bonds, optionally containing 1-3 ring heteroatoms independently selected from O, N, and S, and optionally substituted with one or two groups independently selected from CH 3 , OCH 3 , CO 2 CH 3 , OC(O)CH 3 , CN, and halo, wherein all methyl groups are optionally substituted with 1, 2, or 3 halogen atoms; or R 3 is C 1-6 alkyl, C 1-6 alkanoyl, C 1-6 alkenyl, C 1-6 alkoxy, C 1-6 alkenoxy, wherein said alkyl groups, the alkyl moieties of said alkanoyl and said alkoxy groups, said alkenyl groups, and the alkenyl moieties of said alkenoxy groups may be straight-chain, branched, or cyclic, and can all optionally be substituted as follows: a) with one, two, or three halogen atoms; b) with one or two substituents independently selected from hydroxy, carboxyl, cyano, benzyl, benzoyl, and benzoyloxy; c) with one saturated, unsaturated, or aromatic 5- or 6-membered ring containing 0-3 heteroatoms selected from N, O, and S, said ring optionally substituted with one or two groups independently selected from CH 3 , OCH 3 , C(O)CH 3 , CO 2 CH 3 , OC(O)CH 3 , CN, and halo, wherein all methyl groups are optionally substituted with 1, 2, or 3 halogen atoms; and d) with one group selected from C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbamoyl, ethylcarbamoylmethyl, methylcarbamoylmethyl, 2-hydroxy-2-phenyl-ethylcarbamoylmethyl, or N-phthalimido; or R 3 is R 4 NHC(O), R 4 NHC(S), or R 4 NHCH 2 C(O), wherein R 4 is C 1-6 alkyl, wherein said alkyl group may be straight-chain, branched, or cyclic, and is optionally substituted as described for R 3 alkyl groups, or R 4 is a five- or 6-membered aromatic ring containing 0-3 heteroatoms independently selected from O, N, and S, all R 4 optionally substituted with one or two substituents independently selected from halo, methyl, and benzyl, wherein all rings are optionally substituted with one or two groups independently selected from CH 3 , OCH 3 , CO 2 CH 3 , OC(O)CH 3 , CN, and halo, wherein all methyl groups are optionally substituted with 1, 2, or 3 halogen atoms; and m and n are, independently, 1 or 2, provided that m and n are not both 2; and further provided that when n=1, m=2, and R 1 and R 2 are both H, then R 3 is not methyl.