Patent ID: 6849267

Claim:
A composition comprising a compound in an amount sufficient to detectably inhibit ERK protein kinase activity, and a pharmaceutically acceptable carrier, wherein said compound comprises Grp1, Grp2 and Grp3, wherein; Grp 1 is an optionally substituted phenyl ring; Grp 2 is selected from wherein Grp2 has a hydrogen bond acceptor HBA2, and wherein HBA2 is optionally bonded to a hydrogen bond donor HBD2; and Grp3 is a 5-membered heteroaromatic ring having 1-4 nitrogens and a hydrogen bond donor HBD1; wherein said compound optionally comprises a hydrogen bond acceptor HBA1; and wherein Grp1 is within about 2.5-10.0 Å of Grp2; Grp2 is within about 4.0-8.0 Å of Grp3; Grp3 is within about 5.0-12.0 Å of Grp1; HBA2 is within about 6.5-11.0 Å of Grp1; HBD1 is within about 6.5-8.5 Å of Grp2; HBD1 is within about 3.5-5.5 Å of HBA1; and HBA1 is within about 6.7-14.0 Å of HBD2.