Patent ID: 8778327

Claim:
A composition for treating diabetes, comprising: a) an isolated first plasmid comprising a polynucleotide encoding a secreted glutamic acid decarboxylase (sGAD), but not a pro-apoptotic protein, under the control of a first promoter capable of promoting transcription of the polynucleotide encoding said sGAD; and b) an isolated second plasmid, which is separate and distinct from the first plasmid, the second plasmid comprising a polynucleotide encoding a BAX, but not an autoantigen or a donor antigen, under the control of a second promoter capable of promoting transcription of the polynucleotide encoding said BAX; where the first plasmid comprises a plurality of methylated CpG motifs; and wherein said composition, when administered to a mammalian subject, reduces a blood glucose level in the subject.