Patent ID: 8791108

Claim:
A compound of Formula I where: R 1 is CONR 6 R 7 ; R 2 is hydrogen, halo, or alkyl; R 3 is alkyl; alkenyl; cycloalkyl or cycloalkenyl substituted with 0-2 alkyl substituents; azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, carboxy, and carboxamido; or Ar 2 ; R 4 is alkyl or haloalkyl; R 5 is alkyl; R 6 is alkyl, (R 5 )alkyl, Ar 1 , (Ar 1 )alkyl, (Ar 1 )alkenyl, (Ar 1 )alkynyl, (Ar 1 )cycloalkyl, alkylSO 2 , (Ar 1 )SO 2 , or (Ar 1 )alkylSO 2 ; R 7 is hydrogen, alkyl, or alkoxy; or where NR 6 R 7 together form piperidinyl, piperazinyl, morpholinyl, or tetrahydronapthalinyl, and is substituted with 0-1 substituents selected from alkyl, hydroxyalkyl, alkoxyalkyl, (benzodioxolyl)alkyl, piperidinyl, (morpholinyl)alkyl, (Ar 3 )alkyl, and Ar 3 ; R 8 is adamantyl, hydroxyadamantyl, hydroxycycloalkyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinonyl, alkoxy, alkylthio, phenoxy, or (phenyl)NH; or R 8 is piperidinyl, piperazinyl, morpholinyl, or tetrahydronapthalinyl, and is substituted with 0-1 substituents selected from alkyl, alkylCO, alkylCO 2 , cycloalkylCO, cycloalkylCO 2 , (Ar 3 )alkyl, Ar 3 , benzodioxolyl, piperidinyl morpholinyl, and (morpholinyl)ethyl; R 9 is piperidinyl, piperazinyl, or morpholinyl; R 10 is hydrogen or alkyl; R 11 is hydrogen or alkyl; or NR 10 R 11 is piperidinyl, piperazinyl, or morpholinyl; Ar 1 is phenyl, pyridinyl, pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, benzodioxolyl, or benzthiazolyl, and is substituted with 0-5 substituents selected from halo, hydroxy, alkoxy, cyano, alkyl, cycloalkyl, haloalkyl, haloalkoxy, phenoxy, NR 10 R 11 , CONR 10 R 11 , alkylSO 2 , SO 2 NR 10 R 11 , Ar 3 SO 2 , (Ar 3 )alkylSO 2 , R 9 , and Ar 4 ; Ar 2 is phenyl, pyridinyl, indanyl, naphthyl, tetrahydronaphthalenyl, benzofuranyl, dihydrobenzofuranyl, benzodioxyl, chromanyl, isochromanyl, benzodioxanyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, dihydrobenzoxazinyl, indolyl, dihydroindolyl, benzthiazolyl, or benzothiazolyl, and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, hydroxy, alkoxy, haloalkoxy, phenoxy, benzyloxy, thioalkyl, and acetamido; or Ar 2 is Ar 3 is phenyl substituted with 0-3 substituents selected from halo, alkyl, and alkoxy; and Ar 4 is phenyl, pyridinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl, and is substituted with 0-1 alkyl substituents; or a pharmaceutically acceptable salt thereof.