Patent ID: 7087630

Claim:
A compound of Formula (III) or a pharmaceutically acceptable salt thereof: wherein: R 5 is: (a) —(C(R 4 )(R′ 4 )) k —Y—(C(R 4 )(R′ 4 )) k —B—(C(R 4 )(R′ 4 )) k —O—V; (b) —(C(R 4 )(R′ 4 )) k —Y—(C(R 4 )(R 4 )) k —D—(C(R 4 )(R′ 4 )) k —O—V; (c) —C(Z)—(C(R 4 )(R′ 4 )) k —Y—(C(R 4 )(R′ 4 )) k —O—V; (d) —(C(R 4 )(R′ 4 )) k —Y—W—Q—C(R 4 )(R′ 4 )) k —O—V; (e) —C(Z)—W—Q—(C(R 4 )(R′ 4 )) k —O—V; (f) —(C(R 4 )(R′ 4 )) p —E—N(R i )—O—W—Q—(C(R 4 )(R′ 4 ) k —O—V; (g) —(C(R 4 )(R′ 4 )) p —E—N(R i )—O—(C(R 4 )(R′ 4 ) k —O—V; (h) —(C(R 4 )(R′ 4 )) p —N(R i )—O—(C(R 4 )(R′ 4 ) k —O—V; (i) —(C(R 4 )(R′ 4 )) p —O—N(R i )—(C(R 4 )(R′ 4 ) k —O—V; (j) —(C(R 4 )(R′ 4 )) p —O—N(R i )—E—(C(R 4 )(R′ 4 ) k —O—V; or (k) —(C(R 4 )(R′ 4 )) p —O—N(R i )—E—W—Q—(C(R 4 )(R′ 4 ) k —O—V; B is —C(Z)—, —Y— or a covalent bond; D is —S(O) o or —N(R a )(R i ); R 1 is —S(O) 2 —NH 2 ; R 1 ′ at each occurrence is independently a hydrogen, a halogen, a methyl or CH 2 OH; R 2 is a substituted lower alkyl group, a cycloalkyl group, an aryl group or a heterocyclic ring; R 4 and R′ 4 at each occurrence are independently a hydrogen, a halogen, a lower alkyl group or an alkoxy group; or R 4 and R′ 4 taken together with the carbon atom to which they are attached are a substituted lower alkyl, a cycloalkyl group, an aryl group or a heterocyclic ring; V is —NO, —NO 2 , or a hydrogen; with the proviso that when V is hydrogen and R 5 is variable (a), then at least one of R 4 and R′ 4 must be a halogen; Y at each occurrence is independently an oxygen, —S(O) o — or —N(R a )R i —; Z is an oxo, a thial, an oxime or a hydrazone; Q is Y or a covalent bond; W at each occurrence is independently an aryl group, an alkylaryl group, a heterocyclic ring, or an alkylheterocyclic ring; E is —C(O) or —S(O) o ; R a is a lone pair of electron, a hydrogen, or a lower alkyl group; R i is a hydrogen, an alkyl, an aryl, an alkylcarboxylic acid, an arylcarboxylic acid, an alkylcarboxylic ester, an arylcarboxylic ester, an alkylcarboxamido, an arylcarboxamido, an alkylaryl, an alkylsulfinyl, an alkylsulfonyl, an alkylsulfonyloxy, an arylsulfinyl, an arylsulfonyl, arylsulphonyloxy, a sulfonamido, a carboxamido, a carboxylic ester, an aminoalkyl, an aminoaryl, —(C(R 4 )(R′ 4 )) n —O—V, a bond to an adjacent atom creating a double bond to that atom, or —(N 2 O 2 —) − .M + , wherein M + is an organic or inorganic cation; o is an integer from 0 to 2; k is an integer from 1 to 6; p at each occurrence is independently an integer from 0 to 10; and n at each occurrence is independently an integer from 2 to 10.