Patent ID: 7456260

Claim:
A humanized antibody comprising a heavy chain variable region (V H ) and a light chain variable region (V L ), wherein the CDRs of the heavy chain and light chain variable regions are from a donor antibody, and wherein the heavy chain variable region framework has at least 95% identity to a framework comprised by an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, and SEQ ID NO:11, and wherein the light chain variable region framework has at least 95% identity to a framework comprised by an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:12, SEQ ID NO:13. SEQ ID NO:14 and SEQ ID NO:15.