Patent ID: 8822679

Claim:
A method of making an enantioenriched heteroatom-containing compound, the method comprising subjecting a compound of Formula A to palladium-catalyzed decarboxylative alkylation using an electron-poor ligand, a palladium-based catalyst, and a solvent: wherein: z is 1; Q is N; each of R 1 through R 10 is independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom-containing hydrocarbyl group, or a functional group; Y is hydrogen, a heteroatom, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom-containing hydrocarbyl group, or a functional group; and two or more groups selected from R 1 through R 10 and Y optionally combine to form a ring or a carbonyl group.