Patent ID: 7879886

Claim:
A pharmaceutical composition comprising an amount of a compound represented by formula (I) sufficient to reduce the population of Plasmodium in a human infested with Plasmodium protozoans and suffering from malaria, in combination with a pharmaceutically acceptable excipient, wherein formula (I) is where: R is OH, OR 7 , or N(OH)R 8 ; R 1 is H, CH 3 or an available electron; R 2 is H, CH 3 or an available electron; R 3 is H, CH 3 or an available electron and together with either R 1 or R 2 when one is an available electron, forms a double bond with the R 1 /R 2 carbon; R 4 is H, acyl of 1-4 carbons or alkyl of 1-4 carbons; R 5 is H, OH, O-acyl of 1-4 carbons, O-alkyl of 1-4 carbons, or (CH 2 ) a (R 10 ) b (CH 2 ) a R 10 (CH 2 ) a (R 10 ) b X R 6 is H, OH, alkyl of 1-6 carbons, a halogen, (CH 2 ) a (R 10 )(CH 2 ) r (R 10 )Y, or is C═C—C═C—, which, together with R 11 , when R 11 , is an available electron, forms a fused ring system as follows: R 7 is alkyl of one to four carbons or optionally substituted benzyl; R 8 is H, alkyl of one to four carbons, optionally substituted benzyl, R 9 is H, alkyl of one to four carbons or optionally substituted benzyl; R 10 is O or CH 2 , R 11 is H, OH, O-acyl of 1-4 carbons, O-alkyl of 1-4 carbons or an available electron; A is N, CH or COH; B is S, O, N, CH 2 or CH 2 S; a is 2 or 3; b is 0 or 1; m is an integer from 1 to 8; n is 0 or 1; p is 0, 1 or 2; r is 2 or 3; wherein each of the substituents shown is defined above, or a compound of formula (I) where the ring containing the B and N moieties is fully reduced and contains no double bonds, or a pharmaceutically acceptable salt of the compound represented by formula (I) or a stereoisomer of the compound or mixture of stereoisomers.