Patent ID: 8580273

Claim:
A fusion protein comprising: (i) a receptor binding domain of a TNF-superfamily cytokine of LIGHT having the amino residues 91-240 of SEQ ID NO: 40; (iii) a bacteriophage RB69 fibritin trimerization domain having 20-30 amino acids residues comprising the amino acid residues 455-480 of SEQ ID NO:24, or the amino acid residues 456-480 of SEQ ID NO:24; and (ii) a flexible linker between (i) and (iii), wherein the linker has 5-20 amino acid residues having the amino acid sequence (GSS) a (SSG) b (GS) c (S) d , and a, b, c, d are independently 0, 1, 2, 3, 4, or 5; wherein the receptor binding domain of the TNF-superfamily cytokine is fused to the N-terminus of the linker and the linker is fused to the N-terminus of the fibritin trimerization domain.