Patent ID: 8618283

Claim:
A compound of general formula (III) wherein: X is â€”COâ€”(Y) k â€”(Z) n or SO 2 â€”(Y) k â€”(Z) n ; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group; or Y is a cycloalkenyl or polycycloalkenyl group; each Z is independently selected from hydrogen, or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, alkylamino, alkylaminoalkyl, alkylaminodialkyl, charged alkylaminotrialkyl or charged alkylcarboxylate radical of 1 to 20 carbon atoms; or each Z is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl, aminodialkyl, charged aminotrialkyl, or carboxylate radical; and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y; or each Z may be independently a peptido radical; and wherein R 2 is an alkyl, aryl or an acyl group; and wherein R 3 is a side-chain of an Î±-amino acid used in formation of (III); and wherein R 4 is a 2-substituent of a Î²-amino alcohol used in formation of (III).