Patent ID: 8198305

Claim:
A compound of Formula I or a salt, hydrate, or solvate thereof, wherein: each of R 1a and R 1b is -CD 3 ; or R 1a is CD 3 and R 1b is CH 3 ; R 2 is selected from CH 2 CH 2 CH 2 , CD 2 CD 2 CD 2 , CD 2 CH 2 CH 2 , and CD 2 CH 2 CD 2 ; a) R 3a is selected from H, and D; and R 3b is —OH; or b) R 3a and R 3b are simultaneously F; or c) R 3a and R 3b are taken together, with the carbon atom to which they are bound, to form a carbonyl group; and at least one of R 1a , R 1b , R 2 , R 3a , and R 3b comprises a deuterium atom, and wherein each atom designated as deuterium has a minimum isotopic enrichment factor of at least 3000 (45% deuterium incorporation).