Patent ID: 7705050

Claim:
A method for the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis in a mammal, comprising administering to a mammal in need thereof, a therapeutically effective amount of a compound of an isolated (R)-enantiomer of a 2-aryl-propionic amide of formula (I) and pharmaceutically acceptable salts thereof, wherein: Aryl represents a substituted or unsubstituted aryl group; R represents H, C 1 -C 4 -alkyl, allyl, propargyl, CH 2 —CO 2 H or (CH 2 ) 2 —CO 2 H; R′ is: straight or branched C 1 -C 6 -alkyl, alkenyl, cycloalkyl, or phenylalkyl substituted with one or more carboxy groups CO 2 H; straight or branched C 1 -C 6 -alkyl, alkenyl, cycloalkyl, or phenylalkyl substituted with one or more carboxy groups CO 2 H and with a heteroatom selected from oxygen or sulphur; a residue of formula —CH 2 —CH 2 —X—(CH 2 —CH 2 O) n R wherein R is hereinbefore defined, n being an integer from 0 to 5, whilst X is oxygen or sulphur; a residue of formula (R) or (S)—CH(CH 3 )CH 2 —O—CH 2 —CH 2 —OH; a residue of formula OR, wherein R is hereinbefore defined; a residue of formula (III) wherein Φ represents 2-(1-methyl-pyrrolidyl), 2-pyridyl, 4-pyridyl, 1-imidazolyl, 4-imidazolyl, 1-methyl-4-imidazolyl, 1-methyl-5-imidazolyl or a NRaRb group wherein each Ra and Rb, which may be the same or different, represent C 1 -C 6 alkyl or —(CH 2 ) m —OH hydroxyalkyl wherein m is an integer from 2 to 3, and, alternatively, Ra and Rb together with the atom of N to which they are bound, constitute a heterocycle from 3 to 7 members of formula (IV) wherein Y represents a single bond, CH 2 , O, S or N-Rc, Rc being H, C 1 -C 6 alkyl, (CH 2 ) m —OH hydroxyalkyl, a —(CH 2 ) m —Ar′ residue wherein Ar′ is an aryl, heteroaryl, cycloaliphatic and/or heterocycloaliphatic residue, m′ is zero or an integer from 1 to 3, p and q, each independently, is an integer from 1 to 3; or a heteroaryl selected from the group consisting of, 2-pyridyl or 4-pyridyl, 2-pyrimidinyl or 4-pyrimidinyl; 2-pyrazinyl, 5-methyl-2-pyrazinyl; 3-1,2,4-thiazinyl 3-1,2,4-thiazolyl, 3-1-benzyl-1,2,4-thiazolyl 2-1,3-thiazolidinyl, 2-1,3-thiazolyl, 1,3-oxazolyl, 3-isoxazolyl, 4-dihydro-3-oxo-isoxazolyl, 5-methyl-isoxazol-4-yl, 2-imidazolyl, 4-imidazolyl-5-carboxyamide and 2-imidazolyl-4,5-dicarbonitrile, 5-indanyl, 5-indazolyl, 7-aza-indol-3-yl, 2- or 3- or 4-quinolinyl; wherein the compounds of formula I inhibit the chemotaxis of neutrophils induced by interleukin-8.