Patent ID: 7572816

Claim:
A compound having structural Formula A and pharmaceutically acceptable salts thereof, wherein: said dashed line indicates an optional double bond; Z is selected from the group consisting of CH and N; Y is attached to any position on Y 4 , wherein Y is selected from the group consisting of cyano, —COOR 21 , —CONR 22 R 23 , —CONR 21 NR 22 R 23 , heteroaryl, and compounds having a structural formula selected from the group consisting of A 1 , A 2 , A 3 , A 4 , A 5 ; Y 3 is selected from the group consisting of C 2-8 alkyl and C 2-8 substituted alkyl; Y 4 is C 1-6 alkyl; Z 2 , Z 5 , Z 7 and Z 11 are each independently selected from the group consisting of C═O, C═S, C═NR 17 , C═NNR 22 R 23 , C═NOR 17 , and CR 24 R 25 ; Z 1 , Z 3 , Z 4 , Z 6 , Z 8 , Z 9 and Z 10 are each independently selected from the group consisting of O, S, N, —NH, alkylamino, arylamino, and CR 24 R 25 , with the proviso that none of Z 1 , Z 3 , Z 4 , Z 6 , Z 8 , Z 9 and Z 10 is O or S if Z 1 , Z 3 , Z 4 , Z 6 , Z 8 , Z 9 or Z 10 is the point of attachment to Y 4 , with the further proviso that Z 3 and Z 4 cannot both be O at the same time, with the further proviso that Z 8 and Z 9 cannot both be O at the same time, with the further proviso that Z 9 and Z 10 cannot both be O at the same time, with the further proviso that Z 3 , Z 4 , Z 8 , Z 9 or Z 10 can form double bonds to each other provided that none of Z 3 , Z 4 , Z 8 , Z 9 or Z 10 is O or S; R 2 is selected from the group consisting of R 6 is selected from the group consisting of —OH, alkyloxy, aryloxy, alkylcarboxy, arylcarboxy, —SH, alkylthio, arylthio, —NH 2 , alkylamino, arylamino, N-aryl-N-alkylamino, —NHNH 2 , alkylhydrazino, arylhydrazino, N-aryl-N-alkylhydrazino, —NHOR 17 , —O(P═O)(OR 17 )(OR 18 ), —OCH 2 O(P═O)(OR 17 )(OR 18 ), and —OSO 3 R 17 , R 15 and R 16 are each independently selected from the group consisting of —OH, alkyloxy, aryloxy, —NH 2 , alikylamino, arylamino, N-aryl-N-alkylamino, —NHNH 2 , alkylhydrazino, arylhydrazino, N-aryl-N-alkylhydrazino, —NHOR 17 , alkyl, and aryl; R 17 and R 18 are each independently selected from the group consisting of hydrogen, alkyl, and aryl; R 21 , R 22 and R 23 are each independently selected from the group consisting of hydrogen, alkyl, aryl, or R 22 and R 23 are taken together with the nitrogen to which they are attached forming a saturated cyclic or unsaturated cyclic system containing 3 to 8 carbon atoms with at least one substituent as defined herein; and R 24 and R 25 are each independently selected from the group consisting of hydrogen, halogen, alkyl, and aryl.