Patent ID: 8586550

Claim:
A compound of formula I, or a pharmaceutically acceptable salt or a carboxylate or aminoacetate prodrug thereof: wherein, ring A is benzene, naphthalene, or indole; ring B is thiazole; X is methyl or cyclopropyl; Y is H, C 1-4 alkoxy, or fused with a substituent of ring A to form 3 to 7-membered heterocyclic alkyl or 5 to 14-membered heteroaryl; and Z is methylene or cyclopropane, and optionally, said ring A, ring B, X, Y, and Z are each independently substituted with at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, carboxyl, carbamoyl, tosyl, —CF 3 , C 1-7 alkyl, C 2-7 alkenyl, C 2-7 alkynyl, C 1-4 alkoxy-C 1-4 alkyl, C 1-7 alkoxy, C 1-7 alkenyloxy, C 1-7 alkynyloxy, C 3-7 cycloalkyloxy, phenyl-C 1-4 alkoxy, C 1-4 alkenyloxy-C 1-4 alkyl, C 1-4 alkoxy-C 1-4 alkoxy, C 6-10 aryloxy, 5 to 14-membered heteroaryl-C 1-4 alkoxy, C 3-7 cycloalkyl, C 3-7 cycloalkenyl, 3 to 7-membered heterocyclic alkyl, C 6-10 aryl, 5 to 14-membered heteroaryl, C 1-4 alkylsulfanyl, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, C 6-10 arylsulfanyl, C 6-10 arylsulfinyl, C 6-10 arylsulfonyl, mono- or di-C 1-4 alkylamino, C 1-4 alkanoylamino, C 1-4 alkoxycarbonyl, mono- or di-C 1-4 alkylcarbamoyl, C 1-4 alkanoyl, C 1-4 alkylsulfonylamino, and C 6-10 arylsulfonylamino; and said alkyl, alkenyl, or alkoxy is optionally substituted with a substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, and mercapto; and said cycloalkyl, heterocyclic alkyl, aryl, or heteroaryl is optionally substituted with a substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C 1-4 alkyl, and C 1-4 alkoxy; and said heterocyclic alkyl and heteroaryl each independently contains at least one heteroatom selected from N, O and S; and when X, Y, Z and ring A are respectively hydroxymethyl, H, methylene and chlorobenzene, ring B is neither 2-thiazolyl nor 5-phenylthiazol-2-yl.