Patent ID: 6884889

Claim:
A process for the preparation of a compound of the formula wherein R 1 , R 3 and R 4 are each independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 4 -C 6 cycloalkenyl, C 2 -C 6 alkynyl, halogen, cyano, phenyl, C(O)R 5 , C(O)NR 8 R 9 , OR 10 , SR 11 , and NR 12 R 13 ; R 5 is independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, and C 4 -C 6 cycloalkenyl; R 8 and R 9 are each independently selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 alkenyl, C 4 -C 6 cycloalkenyl and C 3 -C 6 alkynyl; provided the carbon atoms which comprise the carbon-carbon double bond of said C 3 -C 6 alkenyl or the carbon-carbon triple bond of said C 3 -C 6 alkynyl are not the point of attachment to the nitrogen to which R 8 or R 9 is attached; R 10 and R 11 are each independently selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one to three halogen atoms, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 4 -C 6 cycloalkenyl and C 3 -C 6 alkynyl; provided the carbon atoms which comprise said carbon-carbon triple bond of said C 3 -C 6 alkynyl are not the point of attachment to the oxygen or sulfur to which R 10 or R 11 is attached; R 12 and R 13 are each independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 alkenyl, C 4 -C 6 cycloalkenyl and C 3 -C 6 alkynyl; and C(O)R 14 ; provided the carbon atoms which comprise the carbon-carbon double bond of said C 3 -C 6 alkenyl, C 4 -C 6 cycloalkenyl or the carbon-carbon triple bond of said C 3 -C 6 alkynyl are not the point of attachment to the nitrogen to which R 12 or R 13 is attached; R 14 is selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 4 -C 6 cycloalkenyl and C 2 -C 6 alkynyl; R 6 is selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 4 -C 6 cycloalkenyl, C(O)NR 16 R 17 , benzyl, C 3 -C 6 alkenyl and C 3 -C 6 alkynyl; provided the carbon atoms which comprise the carbon-carbon double bond of said C 3 -C 6 alkenyl or the carbon-carbon triple bond of said C 3 -C 6 alkynyl are not the point of attachment to the nitrogen to which R 6 is attached; R 16 and R 17 are each independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 alkenyl, C 5 -C 6 cycloalkenyl and C 3 -C 6 alkynl; provided the carbon atoms which comprise the carbon-carbon double bond of said C 3 -C 6 alkenyl, C 5 -C 6 cycloalkenyl or the carbon-carbon triple bond of the C 3 -C 6 alkynyl are not the point of attachment to the nitrogen to which R 16 and R 17 are attached; and R 7 is selected from the group consisting of CH 3 , CH 2 CH 3 , CH 2 CF 3 and CH 2 CH 2 CH 3 ; and the process comprising; treating a compound of the formula. with a potassium alkoxide of the formula R 7 O—K+ in the presence of a carbocyclic aromatic solvent.