Patent ID: 7041705

Claim:
A method of reducing or substantially completely eliminating irritation around the site of injection upon injection of a formulation containing propofol comprising: administering as a bolus intravenous injection or as an intravenous infusion at the injection site, a stable, sterile and antimicrobial aqueous dispersion comprising a water-insoluble microdroplet matrix of mean diameter from about 50 nm to about 1000 nm consisting essentially of about 1% to about 15% of propofol, 1% up to about 7% of a propofol-soluble diluent, and about 0.8% to about 4% of a surface stabilizing agent, and an aqueous phase comprising a pharmaceutically acceptable water-soluble polyhydroxy tonicity modifier in a quantity sufficient to sufficient to render the final composition isotonic with blood, wherein the dispersion is devoid of additional bactericidal or bacteriostatic preservative agents.