Patent ID: 8664248

Claim:
A method of treating an HIV infection in a mammal, said method comprising administering to said mammal a compound in an amount effective for the treatment of said HIV infection, wherein said compound is selected from the group consisting of: (i) a compound of formula I, wherein: X is H or OH; Y is H or OH; R 1 is H or halogen (F, Cl, Br, I); R 2 is H or halogen (F, Cl, Br, I); R 3 is H, C 1-6 alkyl, C 1-6 fluoroalkyl, or benzyl; R 4 is H, C 1-6 alkyl, or benzyl; and R 5 is H or C 1-6 alkyl; or pharmaceutically acceptable salts or solvates thereof; (ii) a compound of formula Ic, wherein: X is O or N—OH; Y is H or OH; R 1 is H or halogen (F, Cl, Br, I); R 2 is H or halogen (F, Cl, Br, I); R 3 is H, C 1-6 alkyl or benzyl; R 4 is H, C 1-6 alkyl or benzyl; and R 5 is H or C 1-6 alkyl; or pharmaceutically acceptable salts thereof; and (iii) a compound selected from the group consisting of: (R)-5-((3-chloro-4-fluorophenyl)(hydroxy)methyl)-N,3-dihydroxy-4-(hydroxymethyl)picolinamide; 5-(4-fluorobenzyl)-N,3-dihydroxy-4-(hydroxymethyl)picolinamide; 5-((4-fluorophenyl)(hydroxy)methyl)-N,3-dihydroxy-4-(hydroxymethyl)picolinamide; 5-((4-fluorophenyl)(hydroxy)methyl)-N-hydroxy-N,2,2-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide; 5-((4-fluorophenyl)(hydroxy)methyl)-N,3-dihydroxy-4-(hydroxymethyl)-N-methylpicolinamide; 5-((4-fluorophenyl)(hydroxy)methyl)-3-hydroxy-4-(hydroxymethyl)-N-methoxypicolinamide; 5-(4-fluorobenzyl)-N,3-dihydroxy-4-methylpicolinamide; 5-((4-fluorophenyl)(hydroxy)methyl)-N,3-dihydroxy-4-methylpicolinamide; 5-(4-fluorobenzoyl)-N,3-dihydroxy-4-methylpicolinamide; (E)-5-((4-fluorophenyl)(hydroxyimino)methyl)-N,3-dihydroxy-4-methylpicolinamide; and (S)-5-((3-chloro-4-fluorophenyl)(hydroxy)methyl)-N,3-dihydroxy-4-(hydroxymethyl)picolinamide; or pharmaceutically acceptable salts thereof.