Patent ID: 8124638

Claim:
A method of treatment of a condition, which method comprises administration of a therapeutically effective amount of a compound of formula I, wherein X 1 represents —C(R 1 )—; X 2 represents —N—; X 3 represents —C(R 2 )—; X 4 represents —C(R 3 )—; R 1 represents H; R 2 and R 3 independently represent H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl or halo; Y 1 , Y 2 , Y 3 , and Y 4 independently represent —CH— or —CF—; Z 1 represents —CH—, —O—, —S—, —N— or —CH═CH—; Z 2 represents —CH—, —O—, —S— or —N—; provided that: (a) Z 1 and Z 2 are not the same; (b) when Z 1 represents —CH═CH—, then Z 2 may only represent —CH— or —N—; and (c) other than in the specific case in which Z 1 represents —CH═CH—, and Z 2 represents —CH—, when one of Z 1 and Z 2 represents —CH—, then the other represents —O— or —S—; R 4 represents —S(O) 2 N(H)C(O)R 6 , —S(O) 2 N(H)S(O) 2 R 6 , —C(O)N(H)S(O) 2 R 6 , or, when Z 1 represents —CH═CH—, R 4 may represent —N(H)S(O) 2 N(H)C(O)R 7 or —N(H)C(O)N(H)S(O) 2 R 7 ; R 5 represents C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl or di-C 1-3 -alkylamino-C 1-4 -alkyl; R 6 represents C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl, C 1-3 alkoxy-C 1-6 -alkoxy, C 1-6 alkylamino or di-C 1-6 alkylamino; and R 7 represents C 1-6 alkyl, or a pharmaceutically acceptable salt thereof, to a person suffering from such a condition, wherein the condition is hypertension or hypertrophy.