Patent ID: 7511044

Claim:
A compound having the structure: or any pharmaceutically-acceptable salt thereof, wherein: R 2 is independently a partially saturated or unsaturated 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2, 3 or 4 atoms selected from N, O and S, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups and the ring is substituted by 0, 1, 2 or 3 substituents selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, â€”C(â•O)R b , â€”C(â•O)OR b , â€”C(â•O)NR a R a , â€”C(â•NR a )NR a R a , â€”OR a , â€”OC(â•O)R b , â€”OC(â•O)NR a R a , â€”OC(â•O)N(R a )S(â•O) 2 R b , â€”OC 2-6 alkylNR a R a , â€”OC 2-6 alkylOR a , â€”SR a , â€”S(â•O)R b , â€”S(â•O) 2 R b , â€”S(â•O) 2 NR a R a , â€”S(â•O) 2 N(R a )C(â•O)R b , â€”S(â•O) 2 N(R a )C(â•O)OR b , â€”S(â•O) 2 N(R a )C(â•O)NR a R a , â€”NR a R a , â€”N(R a )C(â•O)R b , â€”N(R a )C(â•O)OR b , â€”N(R a )C(â•O)NR a R a , â€”N(R a )C(â•NR a )NR a R a , â€”N(R a )S(â•O) 2 R b , â€”N(R a )S(â•O) 2 NR a R a , â€”NR a C 2-6 alkylNR a R a and â€”NR a C 2-6 alkylOR a ; R 4 is H or methyl; R a is independently, at each instance, H or R b ; and R b is independently, at each instance, phenyl, benzyl or C 1-6 alkyl, the phenyl, benzyl and C 1-6 alkyl being substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, â€”OC 1-4 alkyl, â€”NH 2 , â€”NHC 1-4 alkyl, â€”N(C 1-4 alkyl)C 1-4 alkyl.