Patent ID: 8580957

Claim:
A compound of formula (I) or a salt thereof wherein: A represents a bond or C 1-4 alkyl; X represents: i) a 6 to 10 membered aromatic group, or ii) a 5 to 10 membered heteroaromatic comprising 1, 2 or 3 heteroatoms selected from the group consisting of O, N and S; R 1 represents: i) phenyl optionally substituted by 1 or 2 substituents independently selected from halogen, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, SO 2 C 1-6 alkyl and —COR 7 , ii) a 5 to 10 membered heteroaromatic comprising 1, 2 or 3 heteroatoms selected from the group consisting of O, N and S optionally substituted by 1 or 2 substituents independently selected from halogen, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and —COR 7 , or iii) cyclohexyl; R 2 represents C 1-6 alkyl; R 3 represents C 1-6 alkyl; R 4 represents: i) H, halogen, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 0-6 hydroxyalkyl, SO 2 C 1-6 alkyl, —C(O)NR 8 R 9 , C(O)R 10 , —C 0-6 alkyl—NR 11 R 12 , or ii) —O m C 0-6 alkyl substituted by a 5 or 6 membered heterocyclyl or heteroaromatic each comprising 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S and wherein said hetercyclyl or heteroaromatic is optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano, C 1-6 alkyl, C 1-6 haloalkyl and C 1-6 alkoxy, wherein when the heterocyclyl or heteroatomic is linked through a heteroatom and m is 1, then the heteroatom and O are not directly linked if the resultant arrangement would be unstable; R 4a represents H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy or C 0-6 hydroxyalkyl; R 5 represents H, halogen, —C 1-6 alkyl or —C 1-6 alkoxy; R 6 represents H, —C 1-6 alkyl, —C 0-6 alkylcyano, —C 0-6 alkylC 1-6 alkoxy or C 0-2 alkylCOR 7 ; R 7 represents hydroxyl, C 1-6 alkoxy, —NH 2 , —NHC 1-6 alkyl or N(C 1-6 alkyl) 2 ; R 8 and R 9 independently represent: i) H, C 1-6 alkyl, —C 0-6 alkylphenyl, —C 0-6 alkylheteroaromatic, C 3-6 cycloalkyl, or ii) R 8 and R 9 together with the N to which they are attached form a 5 or 6 membered heterocyclyl or heteroaromatic wherein said heterocyclyl or heteroaromatic may comprise 1, 2 or 3 further heteroatoms independently selected from O, N and S; R 10 represents hydroxyl, C 1-6 alkoxy or a 5 or 6 membered heterocyclyl or heteroaromatic comprising 1, 2, 3 or 4 heteroatoms selected from O, N and S; R 11 and R 12 independently represent: i) H, C 1-6 alkyl; or ii) R 11 and R 12 together with the N to which they are attached form a 5 or 6 membered heterocyclyl or heteroaromatic wherein said heterocyclyl or heteroaromatic may comprise 1, 2 or 3 further heteroatoms independently selected from O, N and S; and m represents 0 or 1.