Patent ID: 6924297

Claim:
A compound of formula (I): and pharmaceutically acceptable salt or solvate thereof wherein: a=0 or 1; b=0 to 3; R 1 is selected from the group consisting of H, halogen, C 1-6 aLkyl, S—C 1-6 alkyl, C 1-6 alkoxy, OCF 3, OCH 2 CF 3 , O-cyclopropyl, OCH 2 -cyclopropyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , NO 2 , OH, CH 2 OC 1-6 alkyl, and CH 2 OH; R 2 each independently is selected from C 1-4 alkyl; R 3 is H or O; R 4 is H or C 1-6 alkyl; R 5 and R 6 each independently are selected from the group consisting of H, halogen, and C 1-3 alkyl; or R 5 and R 6 are taken together to form a cyclopropyl ring; R 7 to R 10 each independently are selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy substituted by one or more fluorine atoms, O-cyclopropyl, OCH 2 -cyclopropyl, S—C 1-6 alkyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , halogen, NO 2 , OH, CH 2 OC 1-6 alkyl, and CH 2 OH; R 11 is selected from the group consisting of H, OH, halogen, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , C 1-6 alkyl, C 1-6 alkoxy, NHCO(C 1-6 alkyl), and ═O; R 12 is selected from the group consisting of H, C 1-6 alkyl, phenyl, phenyl substituted by one or more R 13 , phenyl fused to a heterocycle, naphthyl, naphthyl substituted by one or more R 13 , C 4-7 cycloalkyl, C 4-7 cycloalkyl fused to a benzene ring, OCOC 1-6 alkyl, heteroaryl, and heteroaryl substituted by one or more R 13 ; R 13 is selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkyl substituted by one or more fluorine atoms, C 1-6 alkoxy, C 1-6 alkoxy substituted by one or more fluorine atoms, phenyl, CN, CO 2 H, CO 2 C 1-6 alkyl, OH, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , S(O) n C 1-6 alkyl wherein n is 0, 1 or 2, SO 2 N(C 1-6 alkyl) 2 , CONH 2 , CONHC 1-6 alkyl CON(C 1-6 alkyl) 2 , COC 1-6 alkyl, benzyloxy, CH 2 CO 2 H, CH 2 CO 2 C 1-6 alkyl, NO 2 , and NHCO(C 1-6 alkyl); and provided that: