Patent ID: 8628792

Claim:
A method of manufacturing a drug insert for an implant body adapted for disposition within or adjacent to a body cavity, tissue, duct or fluid of a patient, the method comprising injecting into a precursor sheath body, at an extrusion temperature of less than about 15° C., a mixture comprising latanoprost and a silicone matrix such that the precursor sheath body is substantially filled therewith, the precursor sheath body being substantially impermeable to the latanoprost, curing the mixture, at a curing temperature greater than about 25° C., in the precursor sheath body to provide a cured, filled precursor sheath body containing a precursor drug core; and dividing the cured filled precursor sheath body to form a plurality of drug inserts, wherein the drug inserts comprise inclusions of the latanoprost with an average diameter of less than about 10 μm.