Patent ID: 7052706

Claim:
A method of preparing a sustained release pharmaceutical composition in oral dosage form which comprises (a) blending a medicament and a hydrophobic material and optionally a lubricant and optionally an excipient and optionally an adjuvant polymer at a temperature below that of the melting point of the hydrophobic material to form a substantially homogenous and uniform blend, said medicament being present in an amount greater than about 25% by weight of the pharmaceutical composition and having a water solubility less than about 1 gram per 10 mL of water at 25° C. and 1 atm, and greater than about 100 mg per liter of water at 25° C. and 1 atm, said hydrophobic material having a melting point ranging from at least about 40° C. to about 100° C. at 1 atm pressure, and being present in an amount ranging from about 3% to about 20% by weight of the pharmaceutical composition, and in an amount by weight less than that of the medicament; and (b) compressing the product of step (a) to form a tablet thereof; said pharmaceutical composition being formed in the absence of thermal infusion or melting the hydrophobic material or utilizing a high shear mixer or by heating to temperatures slightly below the melting point of the hydrophobic material, said composition excluding any ingredient in the core that causes disintegration of the tablet.