Patent ID: 8618144

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof: wherein m is 0, 1, 2, 3, or 4; n is 0, 1, 2, 3, 4, or 5; p is 0, 1, or 2; q is 0, 1, 2, 3, or 4; X is â€”COâ€” or â€”SO 2 â€”; Y is selected from the group consisting of: (1) C 1 -C 3 alkylene, optionally substituted with â€”NR 2 R 2 or hydroxy, (2) â€”N(R 6 )â€”, (3) â€”Oâ€”, (4) a bond, and (5) phenylene, optionally substituted with 1 to 3 groups independently selected from R 1 ; Z is selected from the group consisting of: (4) a 5- or 6-membered heterocyclic ring with from 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen, R 1 is selected from the group consisting of: (1) C 1 -C 10 alkyl, optionally substituted with 1 to 5 groups selected from the group consisting of: (a) hydroxy, (b) halogen, (c) cyano, (d) QR 2 , (e) C 3 -C 8 cycloalkyl, (f) Qâ€²COR 3 , (g) â€”S(O) p â€”NR 2 R 2 , (h) â€”N(R 2 )SO 2 R 3 , and (i) Qâ€²CO 2 R 2 , (2) C 3 -C 8 cycloalkyl, (3) oxo, (4) halogen, (5) cyano, (6) QR 2 , (7) â€”S(O) p â€”NR 2 R 2 , (8) Qâ€²COR 3 , (9) â€”N(R 2 )SO 2 R 3 , (10) Qâ€²CO 2 R 2 , and (11) Z, optionally substituted with 1 to 5 groups selected from the group consisting of: (a) R 2 , (b) QR 2 , (e) halogen, and (d) oxo; R 2 is selected from the group consisting of (1) hydrogen, (2) C 1 -C 10 alkyl, optionally substituted with 1 to 5 groups selected from the group consisting of: (a) hydroxy, (b) halogen, (c) â€”CO 2 R 4 , (d) â€”S(O) p â€”C 1 -C 10 alkyl, (e) C 3 -C 8 cycloalkyl, (f) C 1 -C 10 alkoxy, optionally substituted with 1 to 5 halogens, and (g) Z, optionally substituted with 1 to 5 groups selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, C 1 -C 10 alkyl and C 1 -C 10 alkoxy; (3) C 3 -C 8 cycloalkyl, (4) Z, optionally substituted with 1 to 5 groups selected from the group consisting of: (a) halogen, (b) nitro, (c) oxo, (d) â€”NR 4 R 4 , (e) C 1 -C 10 alkoxy, optionally substituted with 1 to 5 halogens, (f) â€”S(O) p â€”C 1 -C 10 alkyl, and (g) C 1 -C 10 alkyl, optionally substituted with 1 to 5 groups selected from hydroxy, halogen, trifluoromethyl, cyano, â€”CO 2 R 4 , C 3 -C 8 cycloalkyl, and QR 5 ; R 3 is selected from the group consisting of: (1) oxo, (2) halogen, (3) R 2 , and (4) â€”NR 2 R 2 ; R 4 is selected from the group consisting of: (1) hydrogen, and (2) C 1 -C 10 alkyl; R 5 is selected from the group consisting of: (1) Z, optionally substituted with 1 to 5 groups selected from the group consisting of halogen, trifluoromethyl, cyano, C 1 -C 10 alkyl, and C 1 -C 10 alkoxy, and (2) C 1 -C 10 alkyl; R 6 is selected from the group consisting of: (1) hydrogen, and (2) C 1 -C 10 alkyl; Q is selected from the group consisting of: (1) â€”N(R 2 )â€”, (2) â€”Oâ€”, and (3) â€”S(O) p â€”; and Qâ€² is selected from the group consisting of: (1) â€”N(R 2 )â€”, (2) â€”Oâ€”, and (3) a bond.