Patent ID: 7792645

Claim:
A method for identifying a compound that binds to chalcone isomerase, said method comprising: a) employing a three-dimensional (3-D) model of chalcone isomerase having the structural coordinates of Table 1, Table 5, Table 6, Table 7 or Table 8, to generate a 3-D model of a chalcone isomerase active site defined by the coordinates of residues 36, 37, 38, 47, 48, 49, 50, 97, 101, 106, 109, 110, 112, 113, 152, 190, 191, and 200 of SEQ ID NO:1, b) designing or selecting a compound that potentially binds to said chalcone isomerase active site, and c) contacting said compound with a chalcone isomerase in vitro and determining its ability to bind thereto, wherein said chalcone isomerase has at least 90% identity with respect to the sequence set forth in SEQ ID NO:1, and has chalcone isomerase enzymatic activity, whereby compounds that bind chalcone isomerase are identified.