Patent ID: 6867210

Claim:
A compound having the Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: Y is R 7 , provided that when Y is R 7 , R 1 is —C(O)NH 2 ; A 1 is N and A 2 and A 3 are CR 2 , or A 3 is N and A 1 and A 2 are CR 2 ; R 1 is selected from the group consisting an optionally substituted alkyl, amino, alkylthio, C(O)R 8 , SO 2 R 8 , OC(O)NH 2 , 2-imidazolinyl, 2-imidazolyl, 3-pyrazolyl, 5-isoxazolyl, and 3-(1,2,4)-triazolyl; each R 2 is selected from the group consisting of hydrogen, optionally substituted alkyl, alkenyl, or alkynyl, halogen, hydroxy, cycloalkyl, cyano, amino, alkylamino, dialkylamino, alkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, and aralkylcarbonylamino; or R 1 and R 2 are taken together with the carbon atoms to which they are attached to form a heterocyclic ring; R 3 , R 4 , R 5 , and R 6 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, and alkylthiol; R 7 is an optionally substituted alkyl; R 8 is selected from the group consisting of alkyl, alkenyl, alkynyl, OR 9 , amino, alkylamino, dialkylamino, alkenylamino, dialkylaminoalkenyl, dialkylaminoalkylamino, dialkylaminoalkenylamino, alkylaminoalkenyl-amino, hydroxyaminoalkenylamino, cycloalkyl, heterocycloalkyl, cycloalkylalkylamino, heterocycloalkylamino, aryl, arylalkyl, arylalkenyl, arylalkynyl, and arylalkylamino, all of which can be optionally substituted, provided that R 8 is not OR 9 when R 1 is SO 2 R 8 ; wherein R 9 is selected from the group consisting of hydrogen, optionally substituted alkyl, and an alkali metal; and X is one of O, S, NH, or CH 2 when Y is other than R 7 ; or X is one of O, S, NH, CH 2 or absent when Y is R 7 ; with the provisos that R 2 is not methoxy if R 5 is trifluoromethyl, R 6 is H, X is O and R 1 is SO 2 CH 2 Ph; or each R 2 is hydrogen when R 1 is carboxy, X is O, A 1 is N, and Y is