Patent ID: 7858600

Claim:
A substituted tetracycline compound, wherein said compound is of the formula: wherein: X is CR 6′ R 6 ; R 2 is hydrogen; R 4 and R 4′ are each alkyl; R 2′ , R 3 , R 10 , R 11 and R 12 are each hydrogen; R 5 is hydrogen or hydroxyl; R 6 and R 6′ are each independently hydrogen or alkyl; R 7 is hydrogen or NR 7c C(═W′)WR 7a ; R 8 is hydrogen; R 9 is hydrogen or NR 9c C(═Z′)ZR 9a ; Z is O; Z′ is O or S; R 9a is substituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkoxy, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted arylcarbonyl, or substituted or unsubstituted phenyl, wherein said substituted alkyl is substituted with halogen, amino, hydroxyl, alkoxy, alkylcarbonyloxy, alkyloxycarbonyl, arylcarbonyloxy, alkoxycarbonylamino, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkylaminoacarbonyl, arylalkyl aminocarbonyl, alkenylaminocarbonyl, alkylcarbonyl, arylcarbonyl, aminoalkyl, arylalkylcarbonyl, alkenylcarbonyl, alkoxycarbonyl, silyl, aminocarbonyl, alkylthiocarbonyl, phosphate, aralkyl, phosphonato, phosphinato, cyano, acylamino, amido, imino, sulfhydryl, alkylthio, sulfate, arylthio, thiocarboxylate, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, cyano, azido, heterocyclyl, alkylaryl, aryl or heteroaryl; further wherein said substituted alkenyl, substituted alkynyl, substituted alkoxy substituted arylsulfonyl, substituted alkoxycarbonyl, substituted arylcarbonyl, or substituted phenyl is substituted with halogen, amino, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy, alkylcarbonyloxy, alkyloxycarbonyl, arylcarbonyloxy, alkoxycarbonylamino, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkylaminoacarbonyl, arylalkyl aminocarbonyl, alkenylaminocarbonyl, alkylcarbonyl, arylcarbonyl, aminoalkyl, arylalkylcarbonyl, alkenylcarbonyl, alkoxycarbonyl, silyl, aminocarbonyl, alkylthiocarbonyl, phosphate, aralkyl, phosphonato, phosphinato, cyano, acylamino, amido, imino, sulfhydryl, alkylthio, sulfate, arylthio, thiocarboxylate, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, cyano, azido, heterocyclyl, alkylaryl, aryl or heteroaryl; R 9c is hydrogen; W is CR 7d R 7e , NR 7b or O; W′ is O or S; R 7a , R 7b , R 7c , R 7d , and R 7e are each independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, arylsulfonyl, alkoxycarbonyl, arylcarbonyl, alkylamino, phenyl or absent; or a pharmaceutically acceptable salt thereof, provided that R 9 is not hydrogen when R 7 is hydrogen.