Patent ID: 7601363

Claim:
A cured sustained-release formulation for implantation, which comprises one of particle combinations, which is selected from the group consisting of (a), (b) and (c), and a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed in the carrier: (a) a particle combination which comprises particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which reacts with the carbonate in an aqueous solution to generate carbon dioxide; (b) a particle combination which comprises particles comprising an active ingredient and a carbonate, and particles comprising a substance which reacts with the carbonate in an aqueous solution to generate carbon dioxide; and (c) a particle combination which comprises particles comprising a carbonate, and particles comprising an active ingredient and a substance which reacts with the carbonate in an aqueous solution to generate carbon dioxide; and wherein (i) the active ingredient is either slightly soluble or insoluble in water (ii) the release rate of the active ingredient from the formulation is accelerated in a body fluid, and (iii) wherein the hydrophobic polymer comprises a non-biodegradable polymer.