Patent ID: 7691860

Claim:
A compound of the general formula (I): wherein: A, B, C and D are each independently a methine group or a nitrogen atom, said methine group optionally having a substituent(s) selected from the group consisting of a halogen atom, a cyano group, a lower alkyl group, a C 3 -C 9 cycloalkyl group, a halo-lower alkyl group, a hydroxy group, a lower alkoxy group, a halo-lower alkoxy group, a lower alkoxycarbonyl group, a lower alkylsulfonyl group, a lower alkylsulfonyloxy group, a group represented by —N(R 2 )R 3 , and a group represented by —Q 1 —Ar 1 , wherein at least one of A, B, C and D is a methine group; Ar 1 is an aryl group or a heteroaryl group, each of which may optionally have a substituent(s) selected from the group consisting of a halogen atom, a nitro group, a hydroxy group, a lower alkyl group, a halo-lower alkyl group, a hydroxy-lower alkyl group, a C 3 -C 6 cycloalkyl group, a lower alkenyl group, a lower alkoxy group, a halo-lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group, a carboxy group, a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkanoylamino group and a group represented by —Q 2 —Ar 2 ; Ar 2 is an aryl group or a heteroaryl group, each of which may optionally have a substituent(s) selected from the group consisting of a halogen atom, a cyano group, a lower alkyl group, a halo-lower alkyl group, a hydroxy-lower alkyl group, a hydroxy group, a lower alkoxy group, a halo-lower alkoxy group, a lower alkylamino group, a di-lower alkylamino group, a lower alkanoyl group and an aryl group; E is a group represented by the following formulae (E1): R 4 is a hydrogen atom, a lower alkyl group, an aralkyl group or an aryl group; Q 1 and Q 2 are each independently a single bond, an oxygen atom, a carbonyl group or a group represented by —N(R 5 )—; R 1 is a lower alkyl group or an aryl group, said aryl group optionally having a substituent(s) selected from the group consisting of a halogen atom, a cyano group, a lower alkyl group, a halo-lower alkyl group, a hydroxy-lower alkyl group, a hydroxy group, a lower alkoxy group, a halo-lower alkoxy group, a lower alkylamino group, a di-lower alkylamino group, a lower alkanoyl group and an aryl group, or is a lower alkylene group linked to linkable position(s) of E; R 2 and R 3 are each independently a hydrogen atom or a lower alkyl group, or are taken together to form a lower alkylene group which may be intervened by an oxygen atom, a sulfur atom or an imino group; and R 5 is a hydrogen atom or a lower alkyl group; or a pharmaceutically acceptable salt or ester thereof.