Patent ID: 7432263

Claim:
An amino-plithalazinone compound represented by formula (I) wherein Ra and Rb are, each independently, a hydrogen atom or a group, optionally further substituted, selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or cycloalkyl C 1 -C 6 alkyl, aryl, aryl C 1 -C 6 alkyl, 5 to 7 membered heterocyclyl or heterocyclyl C 1 -C 6 alkyl with from 1 to 3 heteroatoms selected among nitrogen, oxygen or sulfur; or one of Ra or Rb is hydrogen or an optionally substituted straight or branched C 1 -C 6 alkyl group, and the other is a group selected from —COR′, —CONHR′, —COOR′ or —SO 2 R′, wherein R′ is hydrogen or an optionally substituted group selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, as set forth above; R 1 is a group of formula —CHR 4 R 5 wherein R 4 and R 5 are, each independently, hydrogen or an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or cycloalkyl C 1 -C 6 alkyl, aryl, aryl C 1 -C 6 alkyl, 5 to 7 membered heterocyclyl or heterocyclyl C 1 -C 6 alkyl with from 1 to 3 heteroatoms selected among nitrogen, oxygen or sulfur; or R 1 is a group of formula —NHR′, —NR′COR″, —NR′CONHR″ or —NR′SO 2 R″, wherein R′ has the above reported meanings other than hydrogen, and R″ is hydrogen or has the meanings set forth above for R′; R 2 is a hydrogen atom or it is a group, optionally further substituted, selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or cycloalkyl C 1 -C 6 alkyl, aryl, aryl C 1 -C 6 alkyl, 5 to 7 membered heterocyclyl or heterocyclyl C 1 -C 6 alkyl with from 1 to 3 heteroatoms selected among nitrogen, oxygen or sulfur; any R 3 , being placed in one or more of the free positions 5, 6 and 8 of the phthalazinone ring are, independently from each other, halogen, nitro, carboxy, cyano or a group optionally further substituted selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or cycloalkyl C 1 -C 6 alkyl, aryl, aryl C 1 -C 6 alkyl, 5 to 7 membered heterocyclyl or heterocyclyt C 1 -C 6 alkyl with from 1 to 3 hetero atoms selected among nitrogen, oxygen or sulfur; or R 3 is a group selected from —COR′, —CONHR′, —SO 2 R′, —NR′R″, —NR′COR″, —NR′CONHR′ or —NR′SO 2 R″, wherein R′ and R″ are, the same or different, hydrogen or a group as set forth above; m is 0 or an integer from 1 to 3; or a pharmaceutically acceptable salt thereof with the proviso that i) R 1 can not be 4-methylpyridine when Ra and Rb are hydrogen and ii) R 1 can not be CH 3 ; the compounds N-[3,4-dihydro-4-oxo-1-(4-pyridinylmethyl)-6-phthalazinyl]-acetamide and N-[3,4-dihydro-4-oxo-1-(4-pyridinylmethyl)-6-phthalazinyl]-2,2,2-trifluoro-acetamide, being excluded.