Patent ID: 8658433

Claim:
A compound of the formula E-L-DYE-X—Y for use in a medical phototherapeutic procedure, the compound used to cause at least one of necrosis or apoptosis of a target tissue, wherein: DYE is a photoactive type 2 photodynamic therapy (PDT) agent that may further comprise a photoactive diagnostic agent, a photoactive type 1 phototherapeutic agent, another photoactive type 2 PDT agent, or a combination thereof wherein said type 2 PDT agent operates through a type 2 mechanism requiring formation of singlet oxygen for causing tissue damage; Y is a photoactive type 1 phototherapeutic agent that may further comprise another photoactive type 1 phototherapeutic agent, a photoactive type 2 PDT agent, or a combination thereof wherein said type 1 phototherapeutic agent operates through a type 1 mechanism, does not require oxygen for tissue damage and comprises azide or sulfenate moities; E is a targeting component for targeting the compound to an anatomical and/or physiological site of a patient; L is a linking component for linking E to DYE where L is selected from the group consisting of —(CH 2 ) a —, —(CH 2 ) b CONR 1 —, —N(R 2 )CO(CH 2 ) c —, —OCO(CH 2 ) d —, —(CH 2 ) e CO 2 —, —OCONH—, —OCO 2 —, —HNCONH—, —HNCSNH—, —HNNHCO—, —OSO 2 —, —NR 3 (CH 2 ) e CONR 4 —, —CONR 5 (CH 2 ) f NR 6 CO—, and —NR 7 CO(CH 2 ) g CONR 8 —; and X is a linking component for linking DYE to Y where X is selected from the group consisting of —(CH 2 ) h —, —HNCO—, —(CH 2 ) i CO—, and —(CH 2 ) j OCO— where a to j independently range from 0 to 10.