Patent ID: 8546564

Claim:
A compound of formula I: or a pharmaceutically acceptable salt, solvate or prodrug thereof, or mixture thereof, wherein: is selected from a single bond and a double bond; when is a single bond, X 1 is selected from CR 4 R 5 and NR 6 , and X 2 is selected from CR 7 R 8 and NR 9 ; when is a double bond, X 1 is selected from CR 4 and N, and X 2 is selected from CR 7 and N; X 3 is NR 12 ; provided that at least one of X 1 , X 2 and X 3 is selected from N, NR 6 , NR 9 , and N 12 ; m is 0 or 1; Z 1 is —OR 13 ; Z 2 is —OR 14 ; n is 0; R 1 and R 2 , taken together with the carbon to which they are bound, form a carbonyl group; R 3 , at each occurrence, independently is selected from halogen, C 1-6 alkyl C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 perhaloalkyl, —OH, C 1-6 alkoxy and —CN; R 4 , R 5 , R 7 , and R 8 each independently is selected from H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 perhaloalkyl, —CN, —OR 16 , NR 17 R 18 ; —C(O)R 19 , C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 6 , R 9 , and R 12 each independently is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(O)R 20 , S(O) 2 R 22 , C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered heterocyclyl, 5-10 membered heteroaryl, and —(CR 27 R 28 ) p —R 23 ; R 13 and R 14 , at each occurrence, each independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 16 , at each occurrence, independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 17 and R 18 , at each occurrence, each independently is selected from H, C 1-6 alkyl, C 7-6 alkenyl, C 2-6 alkynyl, —C(O)R 24 , —C(O)OR 25 , C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 19 and R 20 , at each occurrence, each independently is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 22 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered heterocyclyl, 5-10 membered heteroaryl, and —(CR 29 R 30 ) q —R 26 ; R 23 , at each occurrence, independently is selected from C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 24 and R 25 , at each occurrence, each independently is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 26 , at each occurrence, independently is selected from C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered heterocyclyl, and 5-10 membered heteroaryl; R 27 , R 28 , R 29 and R 30 , at each occurrence, each independently is selected from H and C 1-6 alkyl; and p, and q, at each occurrence, each independently is selected from 1, 2, 3, 4, 5 and 6.