Patent ID: 8012471

Claim:
A method for the treatment of a neurodegenerative disease in a mammalian subject, the method comprising the step of administering to said subject an effective amount of a compound inhibiting or decreasing activity of an neprilysin II (IGS5) polypeptide wherein said IGS5 polypeptide has a zinc metallopeptidase activity and comprises a human amino acid sequence having at least 95% sequence identity to SEQ ID NO:2, SEQ ID NO:4 or SEQ ID NO:6 and wherein said compound is selected from the group consisting of: (i) Phosphoramidon; (ii) (3S,2′R)-3-{1-[2′-(ethoxycarbonyl)-4′-phenylbutyl]-cyclopentane-1-carbonylamino}-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid; and (iii) a compound inhibiting expression of IGS5 selected from antisense sequences, oligonucleotides which form triple helices or ribozymes.