Patent ID: 6913763

Claim:
A method for enhanced and controlled delivery of a biologically active agent into the spinal structures and/or the brain of a mammal, particularly a human being that circumvents the blood brain barrier, which includes the steps of: providing an agent drug delivery device via catheter to the epidural space of the mammal and positioning said device within the epidural space, advancing a donor iontophoresis electrode into the epidural space of the mammal, applying a second electrode or receptor iontophoresis electrode that is constructed and arranged to be positioned at a determined internal or external position of the mammal's body but in complementary energy gradient positioning to the first electrode, providing a potential gradient so that delivery of the biologically active agent is accomplished in a direction from said first electrode means directly into the spinal structures and/or the brain thereby essentially bypassing the blood brain barrier of the mammal; and thereby, delivering said biologically active agent directly to the spinal structures and/or to the brain of said mammal.