Patent ID: 8906394

Claim:
A crosslinked hyaluronic acid (HA) composition produced by a process comprising crosslinking HA with a crosslinker by a chemical reaction, wherein the crosslinker comprises a hydrophobic moiety and two or more crosslinking moieties, wherein the hydrophobic moiety is selected from the group consisting of poly (ester amides), poly(caprolactone), polylactide, polyglycolide, poly(lactide-co-glycolide), poly(DL- lactide-co-glycolide), polyhydroxyalkanoate (PHA), poly(3-hydroxybutyrate) (PHB), poly(3- hydroxybutyrate-co-valerate) (PHBV), poly(3-hydroxyproprionate) (PHP), poly(3-hydroxyhexanoate) (PHH), poly(4-hydroxybutyrate), poly(4-hydroxyvalerate); poly(4-hydroxyhexanoate), poly(dioxanone), and a combination thereof, wherein the two or more crosslinking moieties are selected from the group consisting of azeridines, aldehydes, amines, diacrylate, bisacrylamide, and combinations thereof.