Patent ID: 8754068

Claim:
A compound which is selected from the group of: a compound of formula I a compound of formula II a compound of formula III wherein R 1 is isopropenyl or isopropyl; J and E are —H or —CH 3 ; E is absent when the double bond is present; X is a phenyl or heteroaryl ring substituted with A, wherein A is at least one member selected from the group of —H, -halo, -hydroxyl, —C 1-6 alkyl, —C 1-6 alkoxy, —C 1-6 haloalkyl, —NR 2 R 2 , —COOR 2 , —C(O)NR 2 R 2 , —C(O)NR 2 SO 2 R 3 , —SO 2 NR 2 R 2 , —NR 2 SO 2 R 2 , —SO 2 NR 2 R 2 , —C 1-6 cycloalkyl-COOR 2 , —C 1-6 alkenyl-COOR 2 , —C 1-6 alkynyl-COOR 2 , —C 1-6 alkyl-COOR 2 , —NHC(O)(CH 2 ) n —COOR 2 , —SO 2 NR 2 C(O)R 2 , -tetrazole, and -bicyclic heteroaryl-COOR 2 , wherein R 2 is H, —C 1-6 alkyl, or substituted —C 1-6 alkyl and wherein R 3 is C 1-6 alkyl and further wherein n=1-6; Y is selected from the group of —COOR 2 , —C(O)NR 2 R 2 , —C(O)NR 2 SO 2 R 3 , —C(O)NR 2 SO 2 NR 2 R 2 , —NR 2 SO 2 R 2 , —SO 2 NR 2 R 2 , —C 1-6 cycloalkyl-COOR 2 , —C 1-6 alkenyl-COOR 2 , —C 1-6 alkynyl-COOR 2 , —C 1-6 alkyl-COOR 2 , —NHC(O)(CH 2 ) n —COOR 2 , —SO 2 NR 2 C(O)R 2 , -tetrazole, —CONHOH, -bicyclic heteroaryl-COOR 2 , and —B(OH) 2 , wherein n=1-6; and Z is selected from the group of —COOH, —COOR 4 and —CH 2 OH, wherein R 4 is C 1-6 alkyl or C 1-6 alkylphenyl; and pharmaceutically acceptable salts thereof.