Patent ID: 8367418

Claim:
A method for lowering cardiovascular risk for a Type 2 diabetic patient who is being treated with at least one anti-diabetes drug, the method comprising: obtaining from the Type 2 diabetic a first biological sample at a first time point, and from the first biological sample a) determining one or more physiological parameters and a ratio of a Glucose Supply Index (S) to an Insulin Demand Index (D) by determining (S) for the Type 2 diabetic patient calculated as follows: 1+[aggregate of carbohydrate exposure (CE)+hepatic glucose uptake (HGU)+hepatic gluconeogenesis (GNG) and+insulin resistance (IR) for the at least one drug], and (D) calculated as follows: 1+[aggregate of peripheral glucose uptake (PGU)+peripheral insulin exposure (PIE) for the at least one drug]; to obtain an S/D ratio for the at least one drug in the Type 2 diabetic patient; b) assign a first cardiovascular risk score for the Type 2 diabetic patient by summing values for one or more physiological parameters in look-up table provided in FIG. 6 and the S/D ratio; c) obtaining a second biological sample at a second time point from the Type 2 diabetic and repeat steps a) and b) for the second biological sample to obtain a second cardiovascular risk score; d) comparing the first cardiovascular risk score to the second cardiovascular risk score and determining from the comparing that the Type 2 diabetes patient is at greater cardiovascular risk, and administering to the Type 2 diabetes patient a drug, wherein the drug is pH-encapsulated glucose, wherein glucose is released at or above pH of 7.0.