Patent ID: 7348433

Claim:
A compound of Formula B or a pharmaceutically acceptable salt, hydrate, ester or tautomer thereof, wherein: X is selected from a bond, O or S(O)k, wherein k is 0, 1 or 2, R 1 is selected from the group consisting of: (1) hydrogen, (2) halo, (3) hydroxy, (4) C 1-6 alkyl, (5) C 1-6 alkenyl, (6) C 1-6 alkoxy, (7) C 1-6 alkyl-S(O) m —, wherein m is 0, 1, 2 or 3 (8) C 1-6 alkyl-C(O)— (7) C 1-6 alkoxy-C(O)— (9) C 1-6 alkyl-C(O)—O— (10) aryl, (11) aralkyl, (12) aryloxy, (13) aralkoxy, (14) arylthio, (15) aroyl, (16) aroyloxy and wherein the alkyl , alkenyl and aryl portions of items (4)-(16) above are optionally substituted from one up to the maximum number of substituable positions with a member independently selected from the group consisting of: halo, heterocycle, C 1-6 alkoxy, C 1-6 alkyl-S(O) k —, C 1-6 alkyl-C(O)—, C 1-6 alkoxy-C(O), C 1-6 alkyl-C(O)—O, carboxy, hydroxy and aralkoxy, the alkyl portions of said C 1-6 alkoxy, C 1-6 alkyl-S(O) k —, C 1-6 alkyl-C(O)—, C 1-6 alkoxy-C(O) and C 1-6 alkyl-C(O)—O groups optionally substituted with 1-3 substituents independently selected from: halo and hydroxy, said aryl portions of items (10)-(16) above further optionally substituted from one up to the maximum number of substituable positions with C 1-6 alkyl, optionally substituted with 1-3 substituents independently selected from the group consisting of: halo and hydroxy; R 3 is selected from the group consisting of: (1) C 1-6 alkyl, C 2-6 alkenyl or C 3-6 alkynyl, each optionally substituted with 1-3 halo groups. (2) aryl, optionally substituted with 1-3 halo groups, (3) aralkyl, optionally substituted with a substituent independently selected from the group consisting of: C 1-6 alkylsulfonyl and halo, R 4 , R 5 , R 6 and R 7 are each independently selected from the group consisting of: (1) hydrogen, (2) halo, and (3) C 1-6 alkyl, optionally substituted with 1-3 halo groups, R 8 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkyl-C(O)—and aryl, the aryl, alkyl and alkenyl portions are optionally substituted with 1-3 halo groups, R 9 and R 10 are independently selected from the group consisting of: (1) halo, (2) C 1-6 alkyl, (3) C 1-6 alkenyl, (4) C 1-6 alkoxy, (5) C 1-6 alkyl-S(O) k —, wherein k is 0, 1 or 2, (6) C 1-6 alkyl-C(O)—, (7) C 1-6 alkoxy-C(O), (8) C 1-6 alkyl-C(O)—O—, (9) carboxy, (10) hydroxy, and (11) N(R8)2, wherein the alkyl and alkenyl portions of items (2)-(8) above are optionally substituted from one up to the maximum number of substituable positions with a member independently selected from the group consisting of: halo, heterocycle, C 1-6 alkoxy, C 1-6 alkyl-S(O) k —, C 1-6 alkyl-C(O)—, C 1-6 alkoxy-C(O)—, C 1-6 alkyl-C(O)—O—, aralkoxy, carboxy and hydroxy, the alkyl portions of said C 1-6 alkoxy, C 1-6 alkyl-S(O) k —, C 1-6 alkyl-C(O)—, C 1-6 alkoxy-C(O) and C 1-6 alkyl-C(O)—O groups optionally substituted with 1-3 substituents independently selected from halo and hydroxy.