Patent ID: 8034806

Claim:
A compound that exhibits potentiation of mGluR5 response to glutamate as an increase in response to non-maximal concentrations of glutamate in human embryonic kidney cells transfected with rat mGluR5 in the presence of the compound, compared to the response to glutamate in the absence of the compound, comprising: wherein n is 2, 3 or 4; wherein R 1 is hydrogen or an organic radical comprising 1 to 12 carbon atoms; wherein R 2a and R 2b together comprise ═O or ═S or each R 2a and R 2b is independently hydrogen, halogen, hydroxyl, cyano, nitro, thiol, amino, or an organic radical comprising 1 to 6 carbon atoms; and wherein R 5 is an organic radical comprising 4 to 14 carbon atoms, or a pharmaceutically acceptable salt or N-oxide thereof, wherein Y 1 is selected from N and C—R 4 ; wherein Y 2 is selected from N and C—H; wherein each R 3a and R 3b is independently hydrogen, halogen, hydroxyl, cyano, nitro, thiol, amino, or an organic radical comprising 1 to 6 carbon atoms; wherein R 4 is hydrogen, halogen, hydroxyl, cyano, nitro, thiol, or an organic radical comprising 1 to 12 carbon atoms.