Patent ID: 7569236

Claim:
Sustained release microgranules containing a Ginkgo biloba extract, comprising: a neutral core coated with a layer, said layer containing Ginkgo biloba extract with at least one pharmaceutically acceptable excipient; an intermediate water-repellent layer, coating said core, comprising a thermoplastic excipient selected from the group consisting of partially hydrogenated oils, beeswax, carnauba wax, paraffin waxes, silicone waxes, C12-C18 fatty alcohols and fatty acids, solid, semi-synthetic glycerides, glycerol monoesters, diesters or triesters, polyoxyethylene glycols and glycosylated polyoxyethylenated glycerides, monostearate glycerides and mixtures thereof; and an outer polymeric layer which sustains the release of said extract from the active core; wherein the release of total flavone glycosides having the following profile of dissolution rates measured at 37.0° C.±0.5° C., with a Dissolution Test Apparatus I (Basket method at 100 rpm, 900 mL of purified water UV Detection: 272 nm): T (h) DISSOLUTION (w/w) 0.5 hour ≦45% 2 hours <75% 8 hours >60%.