Patent ID: 8022033

Claim:
An echinocandin/carbohydrate complex prepared by the steps of: (a) providing an echinocandin compound represented by the following structure wherein R is an alkyl group, an alkenyl group, an alkynyl group, an aryl group, heteroaryl group, or combinations thereof, R 1 , R 2 , R 3 , R 6 , R 7 and R 10 are independently hydroxy or hydrogen, R 4 is hydrogen, methyl or —CH 2 C(O)NH 2 , R 5 and R 11 are independently methyl or hydrogen, R 8 is —OH, —OSO 3 H, —OPO 3 H 2 , —OPO 3 HR a , or —OPO 2 HR a , where R a is hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenoxy, p-halophenyl, p-halophenoxy, p-nitrophenyl, p-nitrophenoxy, benzyl, benzyloxy, p-halobenzyl, p-halobenzyloxy, p-nitrobenzyl, or p-nitrobenzyloxy; R 9 is —H, —OH, or —OSO 3 H, and pharmaceutically acceptable salts or hydrates thereof; (b) mixing together said echinocandin compound of step (a) to a carbohydrate in a solvent to form a mixture; (c) heating said mixture to solubilize said echinocandin compound and to solubilize or disperse said carbohydrate; (d) allowing said mixture to cool to produce said echinocandin/carbohydrate complex; and (e) isolating said echinocandin/carbohydrate complex.