Patent ID: 7855276

Claim:
A humanized COL-1 monoclonal antibody, comprising: a heavy chain comprising an amino acid sequence as set forth in SEQ ID NO: 8 and a light chain comprising the amino acid sequence of SEQ ID NO: 4, wherein a framework residue at position 79 of SEQ ID NO: 8 and at least five additional framework residues in SEQ ID NO: 8 are substituted with an amino acid from a corresponding position in the amino acid sequence set forth as SEQ ID NO: 6, and wherein the humanized COL-1 antibody retains binding affinity for carcinoembryonic antigen (CEA) and has reduced immunogenicity, as compared to HuCOL-1 AbrCDR , deposited as ATCC Accession No. PTA-4644.