Patent ID: 8294122

Claim:
A fluorescence analyzer comprising: a substrate including a probe configured to interact with a target substance; an excitation light irradiation optical system configured to irradiate the target substance or the probe with excitation light; a fluorescence detection optical system configured to detect fluorescence generated by the irradiation with the excitation light from the excitation light irradiation optical system; and a noise removing optical system comprising a noise removing source, wherein the noise removing optical system is configured to irradiate the substrate with noise removing light, wherein the target substance and a foreign particle are non-specifically stuck to the surface of the substrate, and the target substance and the foreign particle are decomposed by the noise removing light, under a condition that an evanescent field is generated on the surface of the substrate, wherein: the probe is present outside the evanescent field, and inside an area irradiated with excitation light, and the excitation light irradiation optical system is configured to irradiate the target substance or the probe with excitation light after the noise removing optical system irradiates the substrate with noise removing light.