Patent ID: 8768451

Claim:
A method of delivering a therapeutic agent to a target location, the method comprising: (a) using a therapeutic agent delivery device comprising: (i) a conductive element; and (ii) an electrochemical layer including an electroactive polymer matrix, a neurotoxin, a first linking element adapted to bind to the electroactive polymer matrix, a second linking element adapted to bind to the neurotoxin, and a bridging element adapted to form a first bond to the first linking element and a second bond to the second linking element, thereby forming a bridge to connect the electroactive polymer matrix and the neurotoxin; wherein the conductive element is adapted to be connected to a voltage source; (b) positioning a therapeutic agent delivery area of the therapeutic agent delivery device at a target location; and (c) connecting the conductive element to the voltage source, thereby causing an electrochemical reaction resulting in at least one of the first bond and the second bond being severed, thereby causing the neurotoxin to release from the therapeutic agent delivery device and elute to a target location.