Patent ID: 7824707

Claim:
A transdermal therapeutic system (TTS) for administering at least one active pharmaceutical ingredient through the skin of a person in need of continuous administration of said active pharmaceutical ingredient over a period of time of at least 24 hours to about 168 hours, wherein this time period includes at least one time segment of intensive exposure to water of the TTS comprising a backing layer which is: (a) impermeable to the active pharmaceutical ingredient; (b) permeable to water vapor; (c) impermeable to water in liquid form; and (d) is in the form of a film web a reservoir layer comprising the at least one active pharmaceutical ingredient in an amount sufficient for the at least one active pharmaceutical ingredient to be delivered in an effective amount to the blood circulation over the period of time of at least 24 hours to about 168 hours, and an adhesive which retains its adhesive properties over the period of time of at least 24 hours to about 168 hours, and wherein said film web is perforated has between 200 and 2500 pores per cm 2 with a diameter between 2 μm and 150 μm.