Patent ID: 8536161

Claim:
A method for the treatment of a hematopoietic malignancy comprising administering a therapeutic combination as a combined formulation or by alternation to a mammal in need thereof, wherein the therapeutic combination comprises a synergistically effective amount of a compound having Formula I or pharmaceutically acceptable salt thereof, and a synergistically effective amount of one or more chemotherapeutic agents selected from dexamethasone, doxorubicin, rituximab, prednisone, lenalidomide, bortezomib, and rapamycin; wherein the Formula I compound is 4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine having Formula Ia: