Patent ID: 7625880

Claim:
A compound of Formula (III): wherein: R a and R b are each independently selected from among H, halogen, CN, NO 2 , C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, and C 1 -C 4 alkoxy; T is 1 ,6-dimethyl-9-oxo-8,9-dihydro- 1H-imidazo[4,5-h]isoquinolin-2,7-ylene, or 1,7-dimethyl-9-oxo-8,9-dihydro-1H-imidazo[4,5-h]isoquinolin-2,6-ylene; L is —X 250a —Y 250 — or —Y 250 —X 250a —, wherein, X 250a is a substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 haloalkyl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 5 -C 8 cycloalkenyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 haloalkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, or substituted or unsubstituted C 2 -C 6 haloalkynyl; Y 250 is a bond, —O—, —S(═O)—, —S(═O) 2 —, —C(═O)—, —NR 45 —, —NH—, —NHC(═O)—, —NR 45 C(═O)—, —NR 45 C(═O)NR 45 —, —C(═O)NH—, —C(═O)NR 45 —, —OC(═O)—, —C(═O)O—, —NHSO 2 —, —NR 45 SO 2 —, —SO 2 NH—, —SO 2 NR 45 —, —C(R 45 )═NO—, —CH═NO—, —ON═CH—, aryl, —NHC(═O)O—, —OC(═O)NH—, —NR 45 C(═O)O—, or —OC(═O)NR 45 —; where each R 45 is independently selected from among hydrogen, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl; M is N or CH; W is E is oxygen or sulfur; R 100 is halogen, —OH, or an optionally substituted group selected from among C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, phenyl, C 1 -C 4 alkyl(phenyl), C 3 -Cycloalkyl, C 1 -C 4 alkyl(C 3 -C 8 cycloalkyl), C 2 -C 8 heterocycloalkyl, C 1 -C 4 alkyl(C 2 -C 8 heterocycloalkyl), C 1 -C 6 alkoxy, C 1 -C 6 alkenyloxy, C 1 -C 6 alkynyloxy, or —NR 102a R 102b ; R 102a and R 102b are independently hydrogen, or an optionally substituted group selected from among C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, aralkyl, C 3 -C 8 cycloalkyl, C 1 -C 4 alkyl(C 3 -C 8 cycloalkyl), C 2 -C 8 heterocycloalkyl, and C 1 -C 4 alkyl(C 2 -C 8 heterocycloalkyl); R 200 is an optionally substituted group selected from among C 2 -C 10 acyl, C 1 -C 6 alkylsulfonyl, C 2 -C 6 alkenylsulfonyl, arylsulfonyl, C 1 -C 10 alkoxycarbonyl, aminosulfonyl, C 1 -C 6 alkylaminosulfonyl, R 350a is hydrogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 2 -C 6 alkenyl, a substituted or unsubstituted C 2 -C 6 alkynyl, a substituted or unsubstituted C 1 -C 6 haloalkyl, a substituted or unsubstituted C 2 -C 6 haloalkenyl, or a substituted or unsubstituted C 2 -C 6 haloalkynyl; n is 1; or a pharmaceutically acceptable salt or a pharmaceutically acceptable prodrug thereof.