Patent ID: 7553967

Claim:
A compound of formula (A): wherein: R 1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl or (b) CN and —C(NR 10 R 11 )═N—R 12 , any of which may be optionally substituted; R 2 is aryl, which is substituted; R 3 and R 5 -R 8 are independently selected from H, halo, hydroxy, alkyl, haloalkyl, acyl, aryl, cycloalkyl, arylalkyl, heteroarylalkyl, CN, amino, alkylamino, dialkylamino, nitro, —CO 2 H, —C(O)-alkyl, —C(O)-aryl, alkoxy, haloalkoxy, mercapto, alkylthio, arylthio, amido, —SO 2 NH, —SO 3 H, —SO 2 NH-alkyl, —SO 2 N-(alkyl) 2 , aryloxy and heteroaryloxy, any of which may be optionally substituted; R 4 is selected from H, halo, hydroxyl, alkyl, haloalkyl, acyl, aryl, cycloalkyl, arylalkyl, heteroarylalkyl, CN, amino, alkylamino, nitro, —CO 2 H, —C(O)-alkyl, —C(O)-aryl, alkoxy, haloalkoxy, mercapto, alkylthio, arylthio, amido, —SO 2 NH, —SO 3 H, —SO 2 NH-alkyl, —SO 2 N-(alkyl) 2 , aryloxy and heteroaryloxy, any of which may be optionally substituted; R 10 and R 11 are independently selected from H, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl and heterocycloalkylalkyl, any of which may be optionally substituted; R 9 and R 12 are independently selected from alkoxy, —OC(O)-alkyl, —OC(O)-aryl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl and hydroxy, any of which may be optionally substituted; and A is O, NR 9 or S; or a pharmaceutically acceptable salt thereof, provided that R 1 is not alkyl when R 2 is pyridine; provided that at least one of R 3 -R 8 is not H or F when A is O, R 1 is (b) and R 2 is a phenyl ring, a phenyl ring substituted at the para position with halo, —CN, —OCH 3 , —CF 3 or —CO 2 CH 3 , a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety; and provided that R 4 is not methyl when R 3 and R 5 -R 8 are H, A is O, R 1 is (b) and R 2 is 4-chlorophenyl.