Patent ID: 7590493

Claim:
A method for determining whether a test compound is a hepatotoxin, comprising: (a) exposing liver tissue or liver cells to the test compound; (b) preparing a normalized gene expression profile of at least ten genes for said liver tissue or liver cells, wherein the gene expression profile contains the differential gene expression levels for said at least ten genes upon exposure to the test compound, and wherein said at least ten genes are listed in one of Tables 3-3DD; (c) comparing the gene expression profile to a hepatotoxicity model, the hepatotoxicity model comprising: (i) the normalized mean expression levels of said at least ten genes in liver tissue or liver cells exposed to a known hepatotoxin, (ii) the normalized mean expression levels of said at least ten genes in liver tissue or liver cells not exposed to a hepatotoxin, and (iii) information from one or more of Tables 3-3DD; and (d) scoring the comparison to determine whether the test compound is a hepatotoxin.