Patent ID: 6872727

Claim:
A method of inhibiting collagenase/MMP activities in a mammal comprising administering to the mammal in need thereof an effective amount of one or more polycyclic (pyrimidine-2,4(1H, 3H)-diones) with functionalized alkyl groups in the 1-, 3-, or both positions with the general structures Ia and Ib, where: R 1 is hydrogen, methyl, or ethyl; R 2 is hydrogen or methyl; R 3 is mercapto or hydroxyaminoacylalkylthio (—SAlkCONHOH); Alk is C 1 -C 5 branched or unbranched alkyl; R 4 is hydrogen, benzyl, or phenyl; n is 0, 1 or 2; Alk* is C 2 -C 12 branched or unbranched alkylene, with the exception of 3-methylpropylene [—CH 2 —CH 2 —CH(CH 3 )-]; X is mercapto or hydroxyaminoacylalkylthio (—SAlkCONHOH); A is an annealed benzene ring or a 2,3-annealed thiophene ring, wherein the 4,5-positions are optionally substituted with methyl groups or are optionally annealed with a cyclopentene, cyclohexene, or cycloheptene ring, R 5 is hydrogen, 6-methyl, 8-methyl, 6-fluoro, 6-choloro, 6-bromo, 6-methylthio, or 6,7-dimethoxy, as well as the tautomers and pharmacologically relevant salts of these compounds.