Patent ID: 8828973

Claim:
A method of treating an immunosuppressant disorder associated with the sphingosine-1-phosphate receptor modulation, wherein the immunosuppressant disorder is selected from: rheumatoid arthritis, psoriasis, atherosclerosis, autoimmune uveitis, dry eye, inflammatory bowel diseases, atopic allergy, atopic dermatitis, contact dermatitis, multiple sclerosis, Sjogren's syndrome and organ transplant rejection, in a mammal in need thereof, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound represented by Formula I or a pharmaceutically acceptable salt thereof: wherein: R 1 is N or C—R 10 ; R 2 is optionally substituted aromatic heterocycle, optionally substituted non-aromatic heterocycle, optionally substituted cycloalkyl, or optionally substituted cycloalkenyl; R 3 is O, N—R 11 , CH—R 12 or S; R 4 is H or optionally substituted aryl; R 5 is H, halogen, hydroxyl, —OC 1-3 alkyl, or optionally substituted C 1-3 alkyl; R 6 is H, optionally substituted C 1-3 alkyl, halogen, hydroxyl or —OC 1-3 alkyl; R 7 is H or optionally substituted C 1-6 alkyl; R 8 is H or optionally substituted C 1-6 alkyl; R 9 is —OPO 3 H 2 , —P(O)(OH) 2 , —S(O) 2 OH, —P(O)MeOH, —P(O)(H)OH or —OR 15 ; R 10 is H, optionally substituted C 1-6 alkyl, halogen, hydroxyl or —OC 1-3 alkyl; R 11 is H or optionally substituted C 1-3 alkyl; R 12 is H, optionally substituted C 1-3 alkyl, halogen, hydroxyl, —OC 1-3 alkyl or amino; R 13 is H or optionally substituted C 1-3 alkyl; R 14 is H or optionally substituted C 1-3 alkyl; R 15 is H or optionally substituted C 1-3 alkyl; L is CHR 16 ; a is 0, 1, 2, 3, 4 or 5; b is 0, 1, 2, 3, 4 or 5; c is 0 or 1; d is 0, 1, 2 or 3; R 16 is H, optionally substituted C 1-3 alkyl, —OC 1-3 alkyl, halogen, hydroxyl or amino, and R 17 is H or optionally substituted C 1-3 alkyl; with the provisos: a). when R 9 is —OPO 3 H 2 , —P(O)(OH) 2 , —S(O) 2 OH, —P(O)MeOH or —P(O)(H)OH then d is not 0; and b). when R 9 is OR 15 then d is not 0 or 1.