Patent ID: 7038018

Claim:
An antibody or antigen-binding fragment thereof that binds mammalian Bonzo and inhibits the binding of a ligand to said Bonzo, wherein said ligand is selected from the group consisting of: i) a ligand having the amino acid sequence of SEQ ID NO:4; ii) a ligand consisting of an amino acid sequence that is a fragment of SEQ ID NO:4, wherein said fragment is selected from the group consisting of: a) amino acid residues 30–254 of SEQ ID NO:4; b) amino acid residues 1–202 of SEQ ID NO:4; c) amino acid residues 30–202 of SEQ ID NO:4; d) amino acid residues 1–155 of SEQ ID NO:4; e) amino acid residues 30–155 of SEQ ID NO:4; f) amino acid residues 1–117 of SEQ ID NO:4; g) amino acid residues 30–117 of SEQ ID NO:4; and h) amino acid residues 30–95 of SEQ ID NO:4; iii) a ligand having the amino acid sequence of SEQ ID NO:6; iv) a ligand having the amino acid sequence of SEQ ID NO:8; and v) a ligand having the amino acid sequence of amino acid residues 32–101 of SEQ ID NO:8.