Patent ID: 7163922

Claim:
A method for the treatment of a postlesional neuronal disease due to cerebral infarction or traumatic impact characterized by nerve cell necrosis, thereby effecting nerve regeneration, comprising administering an effective amount of a compound to stimulate nerve growth, wherein the compound is of formula (I): wherein X represents NH 2 , NH—(C 1-3 )alkyl or N(C 1-3 alkyl) 2 ; R 1 is a residue derived from the amino acid Phe which may optionally be substituted with one or more methoxy groups, or methyl groups or one or more halogen atoms; or is derived from the amino acid Ile; R 2 is a residue which is derived from any one of the amino acids Gly or Ile; R 3 -and R 4 independently represent H; R 5 represents H; and wherein R 0 represents a group of the formula wherein Y represents —CO—, —CH 2 CO—, —CH═CH—CO— or —OCH 2 CO—, and wherein Z represents a halogen atom, a trifluormethyl group, a methoxy group, or a methyl group; or wherein two neighbouring substituents may form a (C 1-3 ) alkylendioxy group; and wherein n is 0 or an integer of from 1 to 5; or a pharmaceutically acceptable salt thereof.