Patent ID: 8101608

Claim:
A compound of Formula I: in which: U, V and W are independently selected from CR 5 and N; Q is selected from N, NNR 5 , NO and CR 5 ; L 1 is selected from —NR 5 C(O)—, —NR 5 C(O)NR 5 —, —C(O)NR 5 —, —NR 5 — and C 5-10 heteroaryl; L 2 is selected from —O—, —NR 5 C(O)—, —NR 5 C(O)NR 5 —, —C(O)NR 5 — and —NR 5 —; n is selected from 0 and 1; m is selected from 0, 1, 2, 3 and 4; R 1 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 1 is optionally substituted by one to three radicals independently selected from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein a methylene of any alkyl group can be optionally replaced by oxygen; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl substituent of R 1 can be optionally substituted by 1 to 3 radicals independently selected from C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy and hydroxy-substituted-C 1-6 alkyl; R 2 is selected from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 2 is optionally substituted by one to three radicals independently selected from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted C 1-6 alkoxy; R 3 is selected from hydrogen and C 1-6 alkyl; and R 4 is selected from hydrogen, —R 6 , —NR 5 R 6 , and —OR 6 ; R 5 is selected from hydrogen and C 1-6 alkyl; and R 6 is selected from pyrrolyl, imidazolyl, indolyl, furanyl, thiazolyl, and cyclopentyl, each of which is optionally substituted with 1 to 3 radicals independently selected from C 1-6 alkyl, hydroxy, cyano, —NR 5 S(O) 0-2 R 5 , —S(O) 0-2 NR 5 R 5 , —NR 5 S(O) 0-2 NR 5 R 5 , —C(O)NR 5 XNR 5 R 5 , —XNR 5 XNR 5 R 5 , —C(O)R 7 , —C(O)NR 5 XOR 5 , —C(O)NR 5 R 5 , —C(O)NR 5 R 7 , —C(O)NR 5 XR 7 and —XC(O)OR 5 ; wherein each X is independently selected from a bond and C 1-4 alkylene; wherein any alkylene of X can be optionally substituted with hydroxy; and R 7 is C 3-10 heterocycloalkyl-C 0-4 alkyl optionally substituted with a radical selected from dimethylamino, pyrimidinyl, pyrazinyl, diethylamino-ethyl, amino and methyl; or the pharmaceutically acceptable salts, thereof.