Patent ID: 8461164

Claim:
A compound of Formula I-A: wherein: R is a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl-SO q , and aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Z is a single bond, CH 2 , NH, O, S, CH 2 O, OCH 2 , CH 2 CH 2 O, or OCH 2 CH 2 ; q is 0, 1, or 2; R 1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Y is a single bond, C(R 5 ) n O or C(R 5 ) n ; n is 2; alternatively R 1 , Z, and R may be taken together to form a fused 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkylcarbonyl, lower alkoxycarbonyl and lower alkyl-SO q ; R 2 is independently H or lower alkyl; R 4 is H, halogen, lower alkyl, lower alkoxy or lower haloalkyl; R 5 is independently H or lower alkyl; X 1 is NR 3 , O, and S, where R 3 is selected from H, lower alkyl, lower alkylcarbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SO q , or phenyl-SO q optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl-SO q , and aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; X 2 is H, halogen or lower alkyl; and X 3 is H, halogen or lower alkyl; with the proviso that when Y is C(R 5 ) n , R 2 and R 1 may be taken together to form