Patent ID: 7655753

Claim:
A polypeptide comprising a mutant form of ‘rop’ (represser of primer) having four alpha-helices having synthetically attached thereto a plurality of therapeutic or diagnostic moieties, and further comprising a targeting element, wherein at least one alpha-helix of the four alpha-helices is a 19-residue helix having functional amino acids conjugated to said therapeutic agents or diagnostic moieties at positions 2, 8, 10, 14, and 16, wherein the functional amino d1 acids are independently selected from the group consisting of lysine and cvsteine, and said therapeutic agents or diagnostic moieties may be the same or different, and wherein said targeting element is selected from a recombinant antibody, a Fab fragment, a F(ab′)2 fragment, a single chain Fv, a diabody, a disulfide linked Fv, a single antibody domain and a CDR.