Patent ID: 7816117

Claim:
An isolated nucleic acid encoding a mutant of SEQ ID NO: 29, wherein the mutant of SEQ ID NO: 29 comprises: a) the amino acid sequence of SEQ ID NO: 29, except for substitution of one or more residues selected from the group consisting of amino acids 46, 71, 119, 141, 161, 164, 166 and 167 of SEQ ID NO: 29; b) the amino acid sequence of SEQ ID NO: 29, except for insertion of the amino acid sequence QGECVPAK, set forth in SEQ ID NO: 27, in between amino acids 168 and 169 of SEQ ID NO: 29; c) the amino acid sequence of SEQ ID NO: 29, except for deletion of amino acids 172-186 of SEQ ID NO: 29; or d) the amino acid sequence of SEQ ID NO: 29, except for substitution of Ser at position 159 of SEQ ID NO: 29 with Pro; wherein a prokaryotic cell having deletion of a reductase selected from the group consisting of thioredoxin reductase, glutathione reductase, and glutathione oxidoreductase, and expressing the mutant of SEQ ID NO:29 has increased cell growth relative to the same prokaryotic cell that does not express the mutant of SEQ ID NO:29.