Patent ID: 6943032

Claim:
A method for separating and detecting at least one analyte compound, comprising: providing a sample solution containing a plurality of compounds, including at least one analyte compound; providing elongate containment means that is sufficiently transparent to excitation radiation, at least at a plurality of locations along its length, to permit transmission of excitation radiation effective for generating measurable amounts of surface enhanced Raman scattered radiation, and that is sufficiently transparent to such scattered Raman radiation, at least at said plurality of locations, to permit transmission of measurable amounts of such scattered Raman radiation, said containment means containing a metal-doped, surface-enhanced Raman-active sol-gel medium, comprising or defining an elongate path; transporting into said containment means a quantity of said sample solution with a disusing force applied to promote flow to thereby distribute said sample solution upon said sol-gel medium in sufficiently intimate contact with said sol-gel medium for effecting separation of said at least one analyte compound; irradiating said medium, and sample solution distributed thereon, with excitation radiation, at least at a plurality of locations along said elongate path, to generate thereat surface enhanced Raman scattered radiation; collecting at least a portion of said scattered Raman radiation at said plurality of locations; and analyzing said collected radiation to determine the presence of the analyte compound in said sample solution.