Patent ID: 8367095

Claim:
An implantable delivery system for an active agent formulation, comprising: a reservoir made of an impermeable, metallic material; a partition within the reservoir, the partition defining within the reservoir a first chamber and a second chamber; the first chamber in the reservoir containing an osmotic engine; the second chamber in the reservoir containing the active agent formulation, the active agent formulation comprising an active agent; a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber; and a flow modulator comprising (i) two pieces, an outer shell and an inner core, wherein the outer shell and the inner core are made of a non-metallic, non-reactive polymer material, and (ii) an internal fluid channel, wherein the flow modulator is disposed at a second end of the reservoir adjacent the second chamber, the flow modulator comprising the outer shell positioned in an opening at the second end of the reservoir, the outer shell comprising an inner surface, the inner core inserted in the outer shell, the inner core comprising an outer surface, and the internal fluid channel having a spiral shape defined between the outer shell and the inner core, wherein the fluid channel is (i) formed on the outer surface of the inner core that mates with the inner surface of the outer shell, or (ii) formed on the inner surface of the outer shell that mates with the outer surface of the inner core.