Patent ID: 7094794

Claim:
A compound of the formula I wherein R1, R2 are each, independently of one another, H, aryl, COOH, (C 1 –C 6 )-alkylene-COOH, —COO(C 1 –C 6 )-akyl, (C 1 –C 6 -alkylene-COO(C 1 –C 6 )-alkyl, (C 1 –C 6 )-alkyl, (C 2 –C 6 )-alkenyl, (C 1 –C 6 )-alkylene-aryl, heterocycle, (C 1 –C 6 )-alkylene-heterocycle, CF 3 , OCF 3 , CN, (CH 2 ) 1-6 —OH, O—(C 1 –C 6 )-alkyl, CO—(C 1 –C 6 )-alkyl, —C(O)O-alkyl, COOH or CON(R9)(R10), wherein said aryl, (C 1 –C 6 )-alkylene-aryl, heterocycle and (C 1 –C 6 )-alkylene-heterocycle radicals are optionally substituted one or more times by F, Cl, Br, (CH 2 ) 0-2 OH, (C 1 –C 6 )-alkyl, (C 2 –C 6 )-alkenyl, (C 2 –C 6 )-alkynyl, CF 3 , OCF 3 , N(R9)(R10), piperidinone, piperazine, piperazinone, N—(C 1 –C 6 -alkylene)piperazine, N—(C 1 –C 6 -alkylene)piperazinone, morpholine, thiomorpholine, NO 2 , CN, O—(C 1 –C 6 )-alkyl, S(O) 0-2 —(C 1 –C 6 )-alkyl, SO 2 —N(R9)(R10), CO—(C 1 –C 6 )-alkyl, —COOH, (C 1 –C 6 )-alkylene-COOH, COO(C 1 –C 6 )-alkyl, (C 1 –C 6 )-alkylene-COO(C 1 –C 6 )-alkyl, (C 3 –C 10 )-cycloalkyl or phenyl, wherein said piperidinone, pirazine, piperazinone, N—(C 1 –C 6 )-alkylene)piperazine, N—(C 1 –C 6 -alkylene)piperazinone, morpholine, thiomorpholine and phenyl are optionally substituted one or more times by F, Cl, Br (CH 2 ) 0-2 OH, COOH, CN, NO 2 , —O—(C 1 –C 6 )-alkyl, —NH—O—(C 1 –C 6 )-alkyl, —(CO)—NH—O—(C 1 –C 6 )-alkylene-N(R9)(R10), —(CO)—(C 1 –C 6 )-alkyl, —(C 1 –C 6 )-alkyl, CF 3 , OCF 3 or N(R9)(R10); R3 is H, (C 1 –C 6 )-alkyl, (C 1 –C 6 )-alkylene aryl, —C(O)-aryl, (C 1 –C 6 )-alkylene-heterocycle or CO—(C 1 –C 6 )-alkyl, wherein said (C 1 –C 6 )-alkylene aryl, —C(O)-aryl and (C 1 –C 6 )-alkylene-heterocycle radicals are optionally substituted one or more times by F, Cl, Br, (C 1 –C 6 )-alkyl, COOH, COO—(C 1 –C 6 )-alkyl, CF 3 or OCF 3 ; R4, R5 are each, independently of one another, H, F, Cl, Br, (C 1 –C 6 )-alkyl, CF 3 , OCF 3 , NO 2 , N(R9)(R10), CN, O—(C 1 –C 6 )-alkyl, CO—(C 1 –C 6 )-alkyl, COOH, (C 1 –C 6 )-alkylene-COOH, CON(R9)(R10), (C 1 –C 6 )-alkylene-CON(R9)(R10), COO(C 1 –C 6 )-alkyl, (C 1 –C 6 )-alkylene-COO(C 1 –C 6 )-alkyl, S(O) 0-2 —(C 1 –C 6 )-alkyl, S(O) 2 —N(R9)(R10) or CH 2 OH, CH 2 OCH 3 ; R6, R7 are each, independently of one another, H, F, Cl, Br, (C 1 –C 6 )-alkyl, cyclopropyl, tetrafluorocyclopropyl, or difluorocyclopropyl; or R6 and R7 together form the group ═CH 2 ; R8 is H, CH 3 , CF 3 or CH 2 OH; R9 is H or (C 1 –C 4 )-alkyl; R10 is H or (C 1 –C 4 )-alkyl; or R9 and R10 form together, with the N atom to which they are bonded, a 3–9 membered ring system; and pharmaceutically acceptable salts thereof.