Patent ID: 6887889

Claim:
A compound, including enantiomers, stereoisomers, rotamers, tautomers, and racemates of said compound, and pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formula I: wherein: Ar 1 : Z is a moiety selected from the group consisting of R 4 COâ€”; R 4 SO 2 â€”; R 4 N(R 2 â€²)COâ€”; R 4 â€²â€”; and R 4 â€²â€”Oâ€”C(O)â€”; R 2 is H; alkyl; or alkyl (substituted with cycloalkyl); R 2 â€² is H or alkyl; R 3 is a moiety selected from the group consisting of H; alkyl; cycloalkyl; alkyl substituted with cycloalkyl; alkyl substituted with alkoxy; alkyl substituted with CF 3 ; arylalkyl; alkylaryl; tetrahydrofuranyl; tetrahydropyranyl; R 8 SO 2 â€”; and n is a number 1 to 5; R 4 is phenyl substituted with R 7 or phenylalkyl substituted on the phenyl with R 7 ; R 4 â€² is a moiety selected from the group consisting of H; alkyl; cycloalkyl; alkyl substituted with cycloalkyl; alkyl substituted with alkoxy; alkyl substituted with CF 3 ; arylalkyl; alkylaryl; tetrahydrofuranyl; and tetrahydropyranyl; R 5 numbers 1-4 which may be the same or different and are independently selected from phenyl substituted with R 7 ; R 7 numbers 1-3 which may be the same or different and are independently selected from the group consisting of H; halogen; alkyl; OH; alkoxy; NH 2 , NH-alkyl; N(alkyl) 2 ; CN; CF 3 ; NO 2 ; CF 3 O; â€”NHâ€”C(O)-alkyl; â€”CH(O); â€”methylenedioxy; â€”CH 2 OH; benzofuran-2-yl; â€”O(alkyl); â€”C(O)alkyl; and indolyl; and R 8 is selected from the group consisting of alkyl; arylalkyl; alkylaryl; aryl; â€”NH(alkyl); and â€”N(alkyl) 2 .