Patent ID: 7202262

Claim:
A compound of the formula: or pharmaceutically acceptable salts, solvates or stereoisomers thereof wherein: Z is substituted aryl, substituted or unsubstituted cycloalkyl, substituted alkyl, substituted or unsubstitued alkenyl, substituted or unsubstituted arylalkyl; R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, —(CH 2 CH 2 O) n R 6 or any biohydrolyzable group; R 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl; substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, alkoxy, aryloxy, halogen, CF 3 , OCF 3 , OCHF 2 , CN, COOH, COOR 7 , SO 2 R 7 , NO 2 , NH 2 , or N(R 7 ) 2 ; each occurrence of R 7 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl; substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, alkoxy, aryloxy, halogen or CF 3 ; n is an integer from 1 to 7, with the proviso that when R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, then Z is not 2-carboxy ethyl or cyanophenyl.