Patent ID: 8642636

Claim:
A compound of formula (I): wherein: R 1 and R 1a are independently selected from the group consisting of hydrogen, cyano, halogen, —C(═O)R 6 , —C(═O)R 8 , —C(═O)NR 11 R 12 , —CH(═NR 7 ), —CH(═NR 8 ), —C(═NR 7 )R 7 , —C(═NR 7 )R 8 , —C(═NR 8 )R 7 , —C(═NNR 7 )R 7 , —C(═NNR 7 )R 8 , —C(═NNR 8 )R 7 , and —C(S)NR 7 R 11 ; R 3 and R 3a are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, alkyl, cycloalkyl, haloalkyl, alkoxy, and haloalkoxy; R 4 and R 4a are independently selected from the group consisting of halogen, cyano, nitro, R 7 , R 8 , —C(O)R 11 , —C(═O)NR 11 R 12 , —C(═NR 7 )R 7 , —C(═NR 7 )R 8 , —C(═NR 7 )NR 11 R 12 , —S(O) n R 11 , and SF 5 ; R 5 and R 5a are independently selected from the group consisting of R 10 , R 11 , —C(═NR 7 )R 7 , —C(═NR 7 )R 8 , —C(═NR 8 )R 7 , —C(═NR 7 )NR 11 R 12 , —C(═S)NR 11 R 12 , —NR 11 R 12 , —NR 11 C(═O)R 8 , —NR 11 C(═O)R 11 , and —N═C(R 11 )NR 6 ; Z and Z 1 are independently selected from the group consisting of nitrogen and C—R 3 ; R 6 is selected from the group consisting of alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, alkynyl, aryl, and heteroaryl, wherein said alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, alkynyl, aryl, and heteroaryl groups are optionally substituted with one or more groups independently selected from the group consisting of R 8 , R 9 , and R 10 ; R 7 is selected from the group consisting of hydrogen and R 6 ; R 8 is selected from the group consisting of −OR 9 , —OR 11 , —SR 9 , —SR 11 , —NR 9 R 11 , and —NR 11 R 12 ; R 9 is selected from the group consisting of aryl and heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted with one or more groups independently selected from the group consisting of R 10 and R 11 ; R 10 is selected from the group consisting of cyano, nitro, hydroxyl, halogen, alkyl, cycloalkyl, haloalkyl, alkoxy, haloalkoxy, —S(O) n R 11 , —S(O) n NR 11 R 12 , —NR 11 R 12 , —NR 11 (C═O)R 11 , —NR 11 (C═O)NR 11 R 12 , —NR 11 S(O) n R 11 , —NR 11 S(O) n NR 11 R 12 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)NR 11 R 12 , —C(═S)R 11 , and —C(═S)NR 11 R 12 ; R 11 and R 12 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl, and haloalkynyl; R 13 and R 13a are independently selected from the group consisting of —NR 11 C(═S)—, —NR 11 SO 2 NR 11 , —NR 11 SO 2 —, —C(═NR 7 )—, —C(═NR 8 )—, —C(═S)NR 11 —, and —S(O) n NR 11 —; L is a linker selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aryloxy aryl, heteroaryl, and any combination thereof, which may optionally contain one or more nitrogen, oxygen, sulfur, phosphorus, or silicon atoms; and wherein said linker may optionally be substituted with one or more groups independently selected from cyano, nitro, hydroxy, halogen, oxygen, nitrogen, sulfur, alkyl, cycloalkyl, alkoxy, thioalkyl, oxo, oximino, and alkoxyimino; and n is independently 0, 1, or 2; or a salt thereof.