Patent ID: 7351834

Claim:
A compound of Formula I: A—D—B (I) or a pharmaceutically acceptable salt thereof, wherein D is —NH—C(O)—NH—, A is a substituted moiety of the formula: —L—M—L 1 , wherein L is phenyl, optionally substituted by halogen, up to per-halo, and Wn, where n is 0-3; wherein each W is independently selected from the group consisting of C 1 -C 5 linear or branched alkyl, C 1 -C 5 linear or branched haloalkyl up to perhaloalkyl and C 1 -C 3 alkoxy L 1 is selected from pyridinyl substituted by —C(O)R x , and optionally substituted with 1-3 additional substituents independently selected from the group consisting of R 7 and halogen; wherein R x is NR a R b and R a and R b are A) independently a) hydrogen, b) C 1 -C 10 alkyl, c) C 6 aryl, d) pyridinyl e) substituted C 1-10 alkyl, f) substituted C 6 aryl, g) substituted pyridinyl h) -phenylpiperazine(pyridinyl), i) -phenylmorpholinyl, j) -ethylmorpholinyl, k) -ethylpiperidyl, l) -methyl pyrrolidinyl, m) -methyl tetrahydrofuryl, or n) —C 2 H 4 NH(phenyl); where when R a and R b are a substituted group, they are substituted by a) halogen up to per halo, b) hydroxy, c) —N(CH 3 ) 2 , d) C 1 -C 10 alkyl, e) C 1 -C 10 alkoxy, f) halosubstituted C 1-6 alkyl, or g) —OSi(Pr-i) 3 ; or B) R a and R b together form piperazine or a substituted piperazine with substituents selected from the group consisting of a) halogen, b) hydroxy, c) C 1-10 alkyl, d) pyridinyl e) C 1-10 alkoxy, f) C 6 aryl, g) halo substituted C 6 aryl, and h) N-(4-acetylphenyl); M is selected from the group consisting of oxygen and sulfur; and B is phenyl, substituted with 1-3 substituents independently selected from the group consisting of halogen and R 7 , and R 7 is (a) C 1 -C 6 linear or branched alkyl, optionally substituted with 1-3 halogen substituents; or (b) C 1 -C 6 linear or branched alkoxy.