Patent ID: 8318945

Claim:
A method of inhibiting metalloprotein activity in a mammal or of treating a mammal in need of therapy for a pathology, condition, or symptom associated with metalloprotein activity, which comprises administering to the mammal an effective amount of a compound of formula wherein X is O, and wherein R 1 , R 2 , R 3 , individually are hydrogen, and R 4 is a group of formula (III): [[(C 6 -C 10 )aryl] q -[O] p —[(C 6 -C 10 )aryl]-[O] .r —[(C 1 -C 6 )alkyl] o -[C(O)] s —[N(R)]—[C(O)]-[(C 1 )alkyl]-], wherein q, p, r, o, s are individually is 0 or 1, and R is H, (C 1 -C 4 )alkyl, phenyl, or benzyl; provided that R 4 is not biphenylcarbamyl-(C 1 )alkyl, biphenyl(C 1 -C 6 )alkylcarbamyl-(C 1 )alkyl, or phenoxyphenylcarbamyl-(C 1 )alkyl; or a pharmaceutically-acceptable salt thereof.