Patent ID: 7863271

Claim:
A compound of formula I, II or III: wherein R 1 , R 2 and R 3 are independently selected from hydrogen, halogen, cyano, alkyl or aryl sulfoxide, alkyl or aryl sulfone, amino, alkylamino, dialkylamino, acylamino, morpholinyl, â€”O-loweralkyl, hydroxy, loweralkyl, fluoroloweralkyl, O lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl and hydroxyloweralkyk;R 4 is a group chosen from: (i) a saturated nitrogen heterocycle or methyl-substituted saturated nitrogen heterocycle, in which said nitrogen is tertiary, said heterocycle containing at least one 5 or 6-membered ring; and (ii) an imidazolylalkyl residue wherein the imidazole of said imidazolylalkyl is optionally substituted with up to three groups chosen from halogen, (C 1 -C 4 )alkyl, substituted (C 1 -C 4 )alkyl and NH 2 ; and R 10 is chosen from the group consisting of (i) hydrogen; (ii) (C 1 -C 10 )alkyl; (iii) substituted (C 1 -C 10 )alkyl; (iv) heterocyclyl; (v) substituted heterocyclyl; (vi) aryl; and (vii) substituted aryl; R 11 is chosen from the group consisting of hydrogen and (C 1 -C 10 )alkyl; or taken together R 10 , R 11 and the nitrogen to which they are attached form a nitrogenous heterocyle or substituted nitrogenous heterocycle, with the proviso that, when R 10 , R 11 and nitrogen form a morpholine ring, the compound is not endo-N-(3,9-dimethyl-3,9-diazabicyclo[3.3.1] nonan-7-yl)-2morpholinobenzoxazole-4-carboxamide.