Patent ID: 8231900

Claim:
A single dose of sufentanil, provided as a small volume solid tablet for oral transmucosal administration to a subject, comprising: from about 0.25 micrograms (mcg) to 200 micrograms sufentanil, wherein; a) said solid tablet is bioadhesive and adheres to the oral mucosa of said subject, b) said solid tablet is a substantially homogeneous composition and has a volume of less than 30 microliters (mcl); and wherein complete erosion of said solid tablet is evident by visual examination only after a time selected from the group consisting of about 5 minutes, about 10 minutes and about 15 minutes; and c) after administration of said solid tablet to said subject, said solid tablet provides a minimal saliva response and minimal swallowing of sufentanil; at least 55% of drug delivery of sufentanil occurs via the oral transmucosal route; said solid tablet provides a T max of from about 19.8 minutes to about 60 minutes; and said tablet provides a T max with a coefficient of variation of less than 40%.