Patent ID: 7731987

Claim:
An implantable medical device, comprising: a device body and at least one layer comprising a poly(ester-amide) having the formula: an optional primer layer disposed over the device body; a drug reservoir layer disposed over the device body or the primer layer, if opted, wherein the drug reservoir layer comprises one or more therapeutic agents; an optional rate-controlling layer disposed over at least a portion of the drug reservoir layer, if opted; and, an optional top-coat layer disposed as an outermost layer over the device body, the primer layer, if opted, the drug reservoir layer, if opted, or the rate-limiting layer, if opted, wherein: m is an integer from 0 to about 200; p is an integer from 0 to about 200; n is an integer from 1 to about 200; r is an integer from 1 to about 3000; Mw is from about 10,000 Da to about 1,000,000 Da; s is a number from 0 to 1, inclusive; t is a number from 0 to 1, inclusive; v is a number from 0 to 1, inclusive; wherein: s+t+v=1; X has the chemical structure: Y has the chemical structure: Z has the chemical structure: wherein: R 1 , R 1′ and R 4 are independently selected from the group consisting of (1C-12C)alkyl and (2C-12C)alkenyl; R 2 , R 2′ , R 2″ and R 2′″ are independently selected from the group consisting of hydrogen and (1C-4C)alkyl, wherein: the alkyl group is optionally substituted with a moiety selected from the group consisting of —OH, —O(1C-4C)alkyl, —SH, —S(1C-4C)alkyl, —SeH, —COR 6 , —NHC(NH)NH 2 , imidazol-2-yl, imidazole-5-yl, indol-3-yl, phenyl, 4-hydroxyphenyl and 4-[(1C-4C)alkylO]phenyl, wherein: R 6 is selected from the group consisting of —OH, —O(1C-4C)alkyl, —NH 2 , —NH(1C-4C)alkyl, —N(1C-4C)alkyl 1 (1C-4C)alkyl 2 , a stable nitroxide, —O(CH 2 ) 2 OP(═O)(O − )OCH 2 CH 2 N 30 (CH 3 ) 3 , —O(CH 2 CH 2 O) q CH 2 CH 2 OR 7 and where: the stable nitroxide is selected from the group consisting of R 7 is selected from the group consisting of hydrogen, (1C-4C)alkyl, —C(O)CH═CH 2 , —C(O)C(CH 3 )═CH 2 and —O(CH 2 ) 2 OP(═O)(O − )OCH 2 CH 2 N + (CH 3 ) 3 ; or one or more of R 2 , R 2′ , R 2″ and R 2′″ may form a bridge between the carbon to which it is attached and the adjacent nitrogen, the bridge comprising —CH 2 CH 2 CH 2 —; R 3 is selected from the group consisting of (1C-12C)alkyl and(2C-12C)alkenyl, (3C-8C) cycloalkyl, (3C-8C)bicycloalkyl and —(CH 2 CH 2 O) q CH 2 CH 2 —; R 5 is selected from the group consisting of —CH(COR 6 )CH 2 S—, —CH(COR 6 )CH 2 O—, —(CH 2 ) 4 CH(COR 6 )NH—, —CH(COR 6 )CH(CH 3 )O—, and and, q is an integer from 1 to 600, inclusive.