Patent ID: 7361669

Claim:
A compound of formula V: or a pharmaceutically acceptable salt thereof, wherein: A′ is N or CH; Ring A is optionally substituted by 1-3 R 1 ; Ring B is a heteroaryl ring that is optionally substituted at a substitutable nitrogen by R 3 and optionally substituted at a substitutable carbon by R 2a , wherein (i) W is NH, Z is CH, and Y is N, (ii) W is CH, Z is NH, and Y is N, (iii) W is S, Z is N, and Y is CH, (iv) W is S, Z is N, and Y is N, (v) W is N, Z is S, and Y is CH, or (vi) W is S, Z is CH, and Y is N; X is —NH—, —O—, —CH 2 — or —S—; D is C 1-3 alkylidene; G is an aryl or heteroaryl ring that is optionally substituted by 1-4 R 5 ; Each R 1 is independently selected from -R 2 , -T-R 2 , or —V-T-R 2 ; Each R 2 is independently selected from C 1-3 aliphatic, hydroxy, —N(R 3 ) 2 , halo, cyano, —OR 4 , —C(O)R 4 , —CO 2 R 4 , —SR 4 , —S(O)R 4 , —SO 2 R 4 , —N(R 3 )C(O)R 4 , —N(R 3 )CO 2 R 4 , —N(R 3 )SO 2 R 4 , —C(O)N(R 3 ) 2 , —SO2N(R 3 ) 2 , —N(R 3 )C(O)N(R 3 ) 2 , —OC(O)R 4 , phenyl, 5-6 membered heterocyclyl or 5-6 membered heteroaryl; R 2a is C 1-6 alkyl; Each T is independently a C 1-5 alkylidene that is optionally interrupted by —O—, —C(O)—, —S—, —S(O)—, —SO 2 —, or —N(R 3 )—; Each V is independently selected from —O—, —S—, —S(O)—, —SO 2 —, —C(O)—, —N(R 3 )—, —N(R 3 )C(O)—, or —N(R 3 )CO 2 —, —N(R 3 )SO 2 —, —C(O)N(R 3 )—, —SO 2 N(R 3 )—, —N(R 3 )C(O)N(R 3 )—, or —OC(O)—; Each R 3 is independently selected from hydrogen, C 1-6 aliphatic, —C(O)R 4 , —CO 2 R 4 , —SO 2 R 4 , or two R 3 on the same nitrogen together with their intervening nitrogen form a 5-6 membered heterocyclyl or heteroaryl ring having 1-3 ring heteroatoms selected from N, O, or S; R 4 is a C 1-6 aliphatic group; Each R 5 is independently selected from —R 6 , -Q-R 6 , or —V-Q-R 6 ; Each Q is independently a C 1-5 alkylidene that is optionally interrupted by —O—, —C(O)—, —S—, —S(O)—, —SO 2 —, or —N(R 3 )—; and Each R 6 is independently selected from C 1-3 aliphatic, hydroxy, —N(R 3 ) 2 , halo, cyano, —OR 4 , —C(O)R 4 , —CO 2 R 4 , —SR 4 , —S(O)R 4 , —SO 2 R 4 , —N(R 3 )C(O)R 4 , or —N(R 3 )CO 2 R 4 , —N(R 3 )SO 2 R 4 , —C(O)N(R 3 ) 2 , —SO 2 N(R 3 ) 2 , —N(R 3 )C(O)N(R 3 ) 2 , —OC(O)R 4 , phenyl, 5-6 membered heterocyclyl or 5-6 membered heteroaryl.