Patent ID: 7999067

Claim:
An isolated mutant form of stromal cell derived factor-1 (SDF-1) peptide comprising the formula of X p -mSDF-1, wherein said mSDF-1 in said X p -mSDF-1 comprises the amino acid sequence of at least amino acids 1-8 of SDF-1 amino acid sequence consisting of SEQ ID NO:52 and which is optionally extended at the C terminus of amino acids 1-8 of SEQ ID NO: 52 by all or any portion of the remaining sequence of SEQ ID NO:52, shown as amino acids 9-68 of the full-length of SEQ ID NO: 52 and said amino acids 1-8 comprises a mutation at the fourth or the fourth and the fifth amino acids from the N terminus of said amino acids 1-8 of SEQ ID NO:52, and wherein: a) X is serine; b) p equals one; and c) said mutant form comprising X p -mSDF-1 has chemoattractant activity for T cells, is inactivated by dipeptidyl peptidase IV (DPPIV) at a rate that is less than one-half of the rate at which native SDF-1 is inactivated, and is inactivated by MMP-2 at a rate that is less than one-half of the rate at which native SDF-1 is inactivated.