Patent ID: 7320793

Claim:
A composition comprising: (a) a non-natural molecular scaffold comprising: (i) a core particle that is a virus-like particle of an RNA bacteriophage; and (ii) an organizer comprising at least one first attachment site, wherein said organizer is connected to said core particle by at least one covalent bond; (b) an antigen or antigenic determinant with at least one second attachment site, wherein said antigen or antigenic determinant is amyloid beta peptide (Aβ 1-42 ) or a fragment thereof, and wherein said second attachment site is selected from the group consisting of: (i) an attachment site not naturally occurring with said antigen or antigenic determinant; and (ii) an attachment site naturally occurring with said antigen or antigenic determinant, wherein said second attachment site associates with said first attachment site through at least one non-peptide bond; and wherein said antigen or antigenic determinant and said non-natural molecular scaffold interact through said association to form an ordered and repetitive antigen array.