Patent ID: 8242098

Claim:
A method of providing hormone replacement therapy, said method comprising delivering to a female a composition comprising a compound of formula I, or a tautomer thereof, in a regimen which involves delivering a pharmaceutically effective amount of one or more of a selective estrogen receptor modulator to said female, wherein formula I is: wherein: R 1 and R 2 are joined to form —CH 2 CH 2 CH 2 —; n is 3 or 4; R 3 is H; R 4 is H; R 5 is a five or six membered heterocyclic ring having in its backbone 1 heteroatom selected from the group consisting of O, S, and NR 6 and having one CN and one substituent selected from the group consisting of H, halogen, C 1 to C 4 alkyl, and CSR D ; R D is NH 2 ; R 6 is H, C 1 to C 3 alkyl or C 1 to C 4 CO 2 alkyl; Q 1 is S; or a pharmaceutically acceptable salt, tautomer, metabolite, or prodrug thereof; wherein said selective estrogen receptor modulator is selected from the group consisting of EM-800, EM-652, raloxifene hydrochloride, arzoxifene, lasofoxifene, droloxifene, tamoxifen citrate, 4-hydroxytamoxifen citrate, clomiphene citrate, toremifene citrate, pipendoxifene, idoxifene, levormeloxifene, centchroman, nafoxidene, and bazedoxifene.