Patent ID: 8841287

Claim:
A chemical entity selected from the compounds of Formula (I) wherein Z is CH; Y is N; R 1 is: a) —(CH 2 ) 2 OCH 3 , —(CH 2 ) 2 SCH 3 , or C 1-8 alkyl, each independently unsubstituted or substituted with —OH or —CF 3 ; b) —(CH 2 ) 0-2 —Ar 1 , —CHR 2 —Ar 1 , —(CH 2 ) 0-2 —Ar 2 , each of said Ar 1 and Ar 2 independently unsubstituted or substituted with halo, —CH 3 , —OCH 3 , Ar 1 is a 6-membered aromatic carbocyclic ring, Ar 2 is a 5 to 6-membered heteroaromatic ring containing N, S or O; or c) cycloalkyl, —(CH 2 )-(monocyclic cycloalkyl), —(CH 2 )-(bridged polycyclic cycloalkyl) 0-1 , —(CHR 2 )-(monocyclic cycloalkyl), —(CH 2 )-(fused cycloalkyl), —(CH 2 )-(bridged monocyclic cycloalkyl), —(CH 2 ) 0-1 -tetrahydrofuranyl, and —(CH 2 ) 0-1 -tetrahydropyranyl, each independently unsubstituted or substituted with one, two, or three C 1-4 alkyl substituents; R 2 is —C 1-4 alkyl; where R a , R b , and R c are each independently H or C 1-3 alkyl; and pharmaceutically acceptable salts of compounds of Formula (I).