Patent ID: 8722696

Claim:
A pharmaceutical dosage form, comprising at least one particle combined with pharmaceutically acceptable excipients, wherein the particle comprises a co-precipitate applied in a layer surrounding a neutral hydrophilic carrier, and comprises the antiviral compound 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile, at least one surface-active agent, and at least one hydrophilic polymer, said particle prepared by a process comprising spraying, on a neutral hydrophilic carrier, an organic solution, said solution comprising 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile, at least one surface active agent, and at least one hydrophilic polymer, wherein the spraying of whole of the solution occurs in at least two separate steps, each of these steps followed by a grinding step of the product obtained at the end of the preceding step, and wherein the particle comprises: from 15 to 30% in weight of the antiviral compound; from 30 to 60% in weight of a hydrophilic polymer; from 15 to 40% in weight of a neutral hydrophilic carrier; and from 1 to 10% in weight of a surface-active agent; and wherein the amount of 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile in the dosage form ranges from 100 mg to 800 mg.