Patent ID: 8399465

Claim:
A chemical entity selected from compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutically acceptable prodrugs of compounds of Formula (I) wherein A is O, bound at site a or at site b; Z is O or S; G 1 , G 2 and G 3 are each independently CR 4 or N; R 4 is H, —C 1-4 alkyl, or halo; X is CH or N; Y is O, S, or NR 3 ; R 3 is H or —C 1-4 alkyl; when Y is O, then L is —CH 2 —, —CH 2 CH 2 —, or —C(O)—; when Y is S or NR 3 , then L is —CH 2 — or —CH 2 CH 2 —; R 1 and R 2 are each independently H, —C 1-4 alkyl, —C(O)R i , —(CH 2 ) 2 C(O)OR 3 , —(CH 2 ) 2 N(CH 2 CH 3 ) 2 , —(CH 2 ) 3 N(CH 3 ) 2 , —C 3-6 cycloalkyl, —(CH 2 ) 1-4 OCH 3 , indan-2-yl, or —(CH 2 ) 0-2 —(O) 0-1 -phenyl wherein said phenyl is optionally substituted with halo, —OCH 3 , or —SO 2 NH 2 ; provided that R 1 and R 2 are not both H simultaneously; R i is —CH 3 , 4-acetyl-piperazin-1-ylmethyl, 3-methyl-isoxazol-5-ylmethyl, 4-hydroxy-cyclohexyl, or or R 1 and R 2 are taken together as in one of the following assignments (i) and (ii); (i) R 1 and R 2 taken together with the nitrogen member to which they are attached form an unbridged monocyclic moiety, said moiety optionally containing one additional heteroatom member selected from N, O, and S; said moiety being optionally substituted with R 5 and (R 5′ ) m ; m is 0 or 1; when m is 1, R 5′ is —C 1-4 alkyl, halo, or OH; R 5 is selected from H; halo; ═O; —OH; —OR 3 ; —CF 3 ; —S(O)(O)CH 3 ; —C 1-4 alkyl; —OC 1-4 alkyl; —C(CH 3 ) 2 OH; —(CH 2 ) 0-1 C(O)OR 3 ; —N(R 3 ) 2 ; —CH 2 OH; —CH 2 OCH 3 ; —(CH 2 ) 0-2 NR 9 C(O)R 7 ; —(CH 2 ) 0-2 NHS(O)(O)CH 3 ; —C(O)R 8 ; —C 3-6 cycloalkyl; pyrimidin-2-yloxy; 1-piperidinyl; 1-piperidinyl-2-one; 1-pyrrolidinyl; 4-morpholinyl; pyridinyl; pyrimidyl; thiophenylmethyl; 5-oxo-1; 5-dihydro-[1,2,4]triazol-4-yl; —(CH 2 ) 0-2 -phenyl wherein said phenyl is optionally substituted with halo or OCH 3 ; and 1-pyrrolidinyl-2-one optionally substituted with —OH; Q is CH 2 or O; R 7 is —C 1-4 alkyl, —NH 2 , or —OC 1-4 alkyl; R 8 is —C 1-4 alkyl; —NH 2 ; —NHCH 3 ; —C 3-6 cycloalkyl; —(CH 2 ) 0-1 phenyl wherein said phenyl is optionally substituted with halo or CO 2 H; 1-pyrrolidinyl; or E is CH 2 , O, or N(CH 3 ); R 9 is H, —C 1-4 alkyl, or —C 3-6 cycloalkyl; (ii) R 1 and R 2 taken together with the nitrogen member to which they are attached form one of the following R e is H, —C 1-4 alkyl, —C(O)C 1-4 alkyl, —C(O)OC 1-4 alkyl, —C(O)NH 2 , —C(O)-tetrahydrofuranyl, —C(O)CH 2 OH, —C(O)isoxazol-5-yl, —C(O)furan-3-yl, —C(O)pyrazin-2-yl, —C(O)cyclobutyl, —S(O)(O)CH 3 , or 4-methoxycarbonyl-benzyl; R f is H, —CH 3 , or —CH 2 C(O)OR 3 ; R g is H or halo; and R h is bound at site c or d and is selected from H, CF 3 , and halo.