Patent ID: 7067311

Claim:
An isolated nucleic acid molecule consisting essentially of a variant PAPSS1 nucleic acid sequence, wherein said variant PAPSS1 nucleic acid sequence is selected from the group consisting of: a) at least ten contiguous nucleotides of SEQ ED NO:13, wherein said sequence includes nucleotide 729, 1051, or 1645 of SEQ ID NO:13, with the proviso that the nucleotide at position 729 of SEQ ID NO:13 is cytosine, the nucleotide at position 1051 of SEQ ID NO:13 is thymine, or the nucleotide at position 1645 of SEQ ID NO:13 is cytosine; b) at least ten contiguous nucleotides of SEQ ID NO:1, wherein said sequence includes nucleotide 1764 of SEQ ID NO:1, with the proviso that the nucleotide at position 1764 of SEQ ID NO:1 is guanine; c) at least ten contiguous nucleotides of SEQ ID NO:2, wherein said sequence includes nucleotide 552 of SEQ ID NO:2, with the proviso that the nucleotide at position 552 of SEQ ID NO:2 is guanine; d) at least ten contiguous nucleotides of SEQ ID NO:2, wherein said sequence includes nucleotide 755 of SEQ ID NO:2, with the proviso that the nucleotide at position 755 of SEQ ID NO:2 is thymine; e) at least ten contiguous nucleotides of SEQ ID NO:3, wherein said sequence includes nucleotide 639 of SEQ ID NO:3, with the proviso that the nucleotide at position 639 of SEQ ID NO:3 is guanine; f) at least ten contiguous nucleotides of SEQ ID NO:4, wherein said sequence includes nucleotide 368 or 436 of SEQ ID NO:4, with the proviso that the nucleotide at position 368 of SEQ ID NO:4 is thymine or that position 436 of SEQ ID NO:4 has an insertion of the sequence 5′-AGTGTTAGA-3′; g) at least ten contiguous nucleotides of SEQ ID NO:5, wherein said sequence includes nucleotide 596 of SEQ ID NO:5, with the proviso that the nucleotide at position 596 of SEQ ID NO:5 is cytosine; h) at least ten contiguous nucleotides of SEQ ID NO:9, wherein said sequence includes nucleotide 378 of SEQ ID NO:9, with the proviso that the nucleotide at position 378 of SEQ ID NO:9 is cytosine; i) at least ten contiguous nucleotides of SEQ ID NO:10, wherein said sequence includes nucleotide 584 or 697 of SEQ ID NO:10, with the proviso that the nucleotide at position 584 of SEQ ID NO:10 is thymine or the nucleotide at position 697 of SEQ ID NO:10 is guanine; and j) at least ten contiguous nucleotides of SEQ ID NO:11, wherein said sequence includes nucleotide 373 or 398 of SEQ ID NO:11, with the proviso that the nucleotide at position 373 of SEQ ID NO:11 is guanine or the nucleotide at position 398 of SEQ ID NO:11 is guanine; or k) the complement of (a), (b), (c), (d), (e), (f), (g), (h), (i), or (j).