Patent ID: 8338604

Claim:
A compound of Formula I: and isotopes, enantiomers, diastereomers and pharmaceutically-acceptable salts thereof, wherein: R 1 is thiazol-5-yl substituted at the 2 position by an amino group and wherein the amino group is optionally further substituted by a substituent selected from the group consisting of C 1 -C 5 alkyl, C 1 -C 4 alkoxy-C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl-C 1 -C 4 alkyl, aryloxy-C 1 -C 4 alkyl, acetyl, C 5 -C 6 heterocyclo, hydroxy-C 1 -C 4 alkyl, C 5 -C 6 heterocyclo-C 1 -C 4 alkyl, amino-C 1 -C 4 alkyl, C 1 -C 4 alkoxy-C 1 -C 4 alkyl and C 1 -C 4 alkyl-thio; R 2 is phenyl optionally substituted with at least one group selected from C 1 -C 4 alkyl, hydroxy-C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy, halo, cyano, acetyl, C 1 -C 4 alkoxycarbonyl, and carboxyl; R 3 is selected from the group consisting of hydrogen, methyl, hydroxymethyl, hydroxyethyl, carboxy, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkoxy carbonylmethyl, carbamoylmethyl N-substituted with C 1 -C 4 alkyl, R 4 is selected from the group consisting of hydrogen and alkoxycarbonyl, with the proviso that the compound of Formula I is not selected from one of the following compounds: