Patent ID: 8686022

Claim:
A compound of the formula I wherein Ar denotes a substituent of formula (II), (III) or (IV) wherein R 3 denotes C 1-6 -alkyl, C 3-6 -cycloalkyl, C 1-4 -alkoxy, C 1-2 -perfluoroalkyl, 3-methyl-oxetan-3-yl, C 1-2 -perfluoroalkoxy, morpholinyl, wherein the cycloalkyl group may optionally be substituted by C 1-3 -alkyl, wherein R 4 denotes H, C 1-4 -alkyl, C 1-4 -alkoxy, wherein R 5 denotes H, C 1-5 -alkyl-sulphonyl-amino, C 3-6 -cycloalkyl-sulphonyl-amino, (C 1-5 -alkyl-sulphonyl)-(methyl)-amino, (C 3-6 -cycloalkyl-sulphonyl)-(methyl)-amino, C 1-5 -alkyl-carbonyl-amino, C 3-6 -cycloalkyl-carbonyl-amino, (C 1-5 -alkyl-carbonyl)-(methyl)-amino, (C 3-6 -cycloalkyl-carbonyl)-(methyl)-amino, aminocarbonyl, C 1-5 -alkyl-amino-carbonyl, C 3-6 -cycloalkyl-amino-carbonyl, di-(C 1-3 -alkyl)-amino-carbonyl, di-(C 1-3 -alkyl)-amino-C 1-2 -alkyl, di-(C 1-3 -alkyl)-amino-pyrrolidin-1-yl-C 1-2 -alkyl, 4-C 1-5 -alkyl-piperazin-1-yl-C 1-2 -alkyl, 4-di-(C 1-3 -alkyl)-amino-piperidin-1-yl-C 1-2 -alkyl, 3-di-(C 1-3 -alkyl)-amino-piperidin-1-yl-C 1-2 -alkyl, C 1-5 -alkyl-sulphinyl, C 3-6 -cycloalkyl-sulphinyl, C 1-5 -alkyl-sulphonyl, C 3-6 -cycloalkyl-sulphonyl, hydroxy-C 1-2 -alkyl, C 1-5 -alkyl-sulphinyl-methyl, C 1-5 -alkyl-sulphonyl-methyl, wherein R 6 denotes C 1-3 -alkyl or phenyl, wherein the C 1-3 -alkyl group may optionally be substituted by hydroxy or di-(C 1-3 -alkyl)-amino and the phenyl group may optionally be substituted by fluorine or C 1-3 -alkyl, wherein D or E represents nitrogen, wherein G and Eâ€² independently of one another represent nitrogen or oxygen, wherein R 6 is only bound to Eâ€² if Eâ€² denotes nitrogen, R 1 denotes a C 4-6 -cycloalkyl system, which contains 1 to 2 nitrogen atoms that may optionally be 1- to 2-substituted by R 7 , wherein R 7 may be C 1-3 -alkyl, hydroxy, C 1-3 -alkoxy, amino, C 1-3 -alkyl-amino, di-(C 1-3 -alkyl)-amino, R 2 denotes hydrogen, halogen or C 1-4 -alkyl, L denotes â€”C(H)< or â€”N<, M denotes â€”C(H)< or â€”N<, T denotes a bond or C 1-4 -alkylene, while the C 1-4 -alkylene group may be substituted by C 1-2 -alkyl, m denotes 0, 1, 2 or 3, n denotes 1, 2 or 3, p denotes 0, 1, 2 or 3, while, unless stated otherwise, the above-mentioned alkyl groups may be straight-chain or branched, the tautomers, the stereoisomers, the mixtures and the physiologically acceptable salts thereof.