Patent ID: 8252803

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or hydrate thereof; wherein: R a and R b independently represent H, F, C 1-4 -alkyl or phenyl provided R a and R b are not both phenyl; Z is selected from: (a) a spiro-linked moiety of formula: where m and n are integers of from 0-4 such that m+n is 3 or 4; (b) a moiety CH—NR 1 R 2 where R 1 and R 2 independently represent H or C 1-6 alkyl, or together with the nitrogen atom to which they are attached complete a non-aromatic N-heterocyclyl group of 5 or 6 ring atoms bearing 0-3 substituents selected from C 1-4 -alkyl, halogen, CF 3 , OR 3 and CO 2 R 3 , or said N-heterocyclyl group may be fused to a benzene ring which bears 0-3 substituents selected from C 1-4 -alkyl, halogen, CF 3 , OR 3 and CO 2 R 3 , where R 3 represents H or C 1-4 alkyl, and (c) a moiety CH-Het where Het represents a 5-membered heteroaryl group which optionally bears a substituent selected from halogen, C 1-4 -alkyl, CF 3 and phenyl; W represents N or CH, V represents S, CR 4 ═CR 5 , CR 4 ═N or N═CR 4 ; with the proviso that when V represents N═CR 4 , W represents CH; R 4 and R 5 independently represent H or (CH 2 ) p —X, where p is 0 or 1 and X represents halogen, 5- or 6-membered heteroaryl, CN, CF 3 , R 6 , OR 6 , N(R 6 ) 2 , SO 2 R 6 , CO 2 R 6 or CON(R 6 ) 2 where each R 6 independently represents H, phenyl, C 1-4 -alkyl or hydroxyC 1-4 -alkyl; or R 4 and R 5 together may complete a fused 5- or 6-membered carbocyclic or heterocyclic ring; and Ar represents a phenyl ring bearing from 2 to 4 substituents selected from: (a) C 1-6 alkyl; (b) C 3-6 cycloalkyl; (d) C 3-6 cyclo alkylC 1-6 alkyl; (e) C 2-6 alkenyl; (f) mono-or bicyclic aryl groups of up to 10 ring atoms, optionally bearing up to 2 substituents selected from halogen, CF 3 and C 1-6 alkyl; (g) OR 7 ; (h) CO 2 R 7 ; (i) N(R 7 ) 2 (j) SR 7 ; and (k) CF 3 ; where each R 7 represents C 1-6 alkyl or two R 7 groups attached to the same nitrogen may complete an N-heterocyclyl group bearing 0-2 substituents selected from halogen, CF 3 , C 1-4 -alkyl and C 1-4 alkoxy; or the ring represented by Ar may be fused to a mono- or bicyclic carbocyclic or heterocyclic ring system of up to 10 ring atoms.