Patent ID: 7582626

Claim:
A compound of Formula I wherein Z is X is N, Y is —(CR 4 R 5 ) n —, n is 2, 3, 4, or 5, R 1 and R 6 are independently H or C 1 -C 6 alkyl, R 2 , R 3 , R 4 , and R 5 are independently H, C 1 -C 6 alkyl, halo, or R 2 and R 3 or R 4 and R 5 combine with the atom to which they are attached to form a 3- to 6-membered spirocyclic ring, R 7 is H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, —C 1 -C 6 alkylene(C 3 -C 8 cycloalkyl), —C 1 -C 6 alkylene(aryl), —C 1 -C 6 alkylene(heterocyclyl), aryl, heterocyclyl, or —NR 10 R 11 , wherein R 10 and R 11 are independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, or C 2 -C 6 alkenyl R 8 is H, halo, nitro, —CHR 12 S(O) 2 R 13 , —C(S(O) 2 R 13 )═CHR 12 —, —NR 13 R 14 , —NR 12 S(O) 2 R 13 , or —NR 12 S(O) 2 NR 13 R 14 , wherein R 12 , R 13 , and R 14 are independently H, C 1 -C 6 alkyl C 3 -C 8 cycloalkyl, aryl, or heterocyclyl, or R 12 and R 13 or R 13 and R 14 combine with the atom(s) to which they are attached to form a 5- or 6-membered heterocyclyl ring, wherein the above alkyl, alkylene, aryl, cycloalkyl, or heterocyclyl moieties provided in R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 10 , R 11 , R 12 ,R 13 , and R 14 are each optionally and independently substituted by 1-3 substituents selected from alkylamine, amino, aryl, cycloalkyl, heterocyclyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms, carboxyl, cyano, halo, hydroxy, nitro, —C(O)OH, —C(O) 2 —(C 1 -C 6 alkyl), —C(O) 2 —(C 3 -C 8 cycloalkyl), —C(O) 2 -(aryl), —C(O) 2 -(heterocyclyl), —C(O) 2 —(C 1 -C 6 alkylene)aryl, —C(O) 2 —(C 1 -C 6 alkylene)heterocyclyl, —C(O) 2 —(C 1 -C 6 alkylene)cycloalkyl, —C(O)(C 1 -C 6 alkyl), —C(O)(C 3 -C 8 cycloalkyl), —C(O)(aryl), —C(O)(heterocyclyl), —C(O)(C 1 -C 6 alkylene)aryl, —C(O)(C 1 -C 6 alkylene)heterocyclyl, and —C(O)(C 1 -C 6 alkylene)cycloalkyl, wherein each of the above optional substituents can be further optionally substituted by 1-5 substituents selected from amino, cyano, halo, hydroxy, nitro, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkenyl, and C 1 -C 6 hydroxyalkyl, wherein each alkyl is optionally substituted by one or more halo substituents, or a pharmaceutically acceptable salt, hydrate, tautomer or stereoisomer thereof.