Patent ID: 8653054

Claim:
A 2-(N-substituted piperazinyl) steroid derivative of Formula I and having antiproliferative activity: wherein; a) Y and Y 1 are OH, OMe, OSO 2 NH 2 , CHOHMe, or b) Z is H, C≡CH, or Me; c) Y and Z on the same carbon atom may be a double bonded oxygen (═O); d) R is H; and e) V is L-proline, L-phenyialanine, D-proline, D-phenylalanine, or tetrahydroisoquinolone; and wherein the variables W and X are linked to form the linkage W—X, and wherein W—X is selected from the group consisting of or a pharmaceutically acceptable salt thereof, an N-oxide thereof or a solvate thereof.