Patent ID: 7825150

Claim:
A method of treating rheumatoid arthritis or graft-versus-host disease, which comprises administering to a patient in need thereof an immunosuppressant and a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: Z is optionally substituted alkyl; R 1 is hydrogen or optionally substituted alkyl or aryl; R 2 is hydrogen or optionally substituted lower alkyl; R 3 is OR 3A , NHC(O)R 3A , NHSO 2 R 3A or hydrogen; and R 3A is independently hydrogen or optionally substituted alkyl, aryl, alkylaryl, arylalkyl, heteroalkyl, heterocycle, alkylheterocycle, or heterocyclealkyl; and wherein the immunosuppressant is methotrexate or cyclosporin.