Patent ID: 8349847

Claim:
A compound of formula-I, or a pharmaceutically acceptable salt thereof, where in m is 1, 2, or 3; W is single bond; R 1 is C 2 -C 6 alkyl, when n=1; C 1 -C 6 alkyl, when n=2 or 3; or C 1 -C 6 alkenyl, alkynyl, NH, S, SO, SO2, O, C═O or an amide group, when n=1, 2 and 3; or each R 1 is independently selected from halo, hydroxy, amino, hydroxyamino, carboxy, nitro, guanidino, ureido, carbamoyl, cyano, trifluoromethyl; or each R 1 is independently selected from the group consisting of C 2 -C 6 alkyl, when n=1; C 1 -C 6 alkyl, when n=2 or 3; and C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkoxy; (C 1 -C 6 ) alkoxycarbonyl, aryloxy, heteroaryloxy, C 1 -C 6 thioalkoxy, C 3 -C 6 thiocycloalkoxy, thioaryloxy, thioheteroaryloxy, nitro, amino, N-mono(C 1 -C 6 ) alkylamino, N,N-di(C 1 -C 6 ) alkylamino, formamido, amido, acetamido, hydroxylamino, C 1 -C 6 alkoxyamino, hydrazino, trifluoromethyl, trifluoromethoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heterocyclyl, fused aryl, fused heteroaryl and fused heterocyclyl, when n=1, 2 and 3; or each R 1 is independently selected from R 3 -sulfonylamino, phthalimido-(C 1 -C 4 )-alkylsulfonylamino, benzamido, benzenesulfonylamino, 3-phenylureido, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, and C 2 -C 4 alkanoylamino and wherein said benzenesulfonylamino or phenyl or phenoxy or anilino or phenylsulfanyl substituent in R 1 may optionally bear one or two halogens, (C 1 -C 4 ) alkyl, cyano, methansulfonyl or (C 1 -C 4 ) alkoxy substituents; or any two R 1 taken together with the carbons to which they are attached comprise a 5-8 membered ring comprising at least one or two heteroatoms selected from oxygen, sulfur or nitrogen; and wherein the alkyl groups and alkyl portions of the alkoxy or alkylamino groups may be straight chained or if comprising at least three carbons may be branched or cyclic; where R 3 is selected from C 1 -C 6 -alkyl, C 3 -C 6 cycloalkyl when n=1, 2 and 3; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxycarbonyl, aryl, heteroaryl, C 1 -C 6 thioalkyl, trifluoromethyl, trifluoromethoxy, heterocyclyl, fused aryl, fused heteroaryl and fused heterocyclyl; or R 2 is selected from the group consisting of phenyl or benzyl and substituted with 1, 2, 3 or 4 groups and the substituents are independently selected from R4, where R4 is selected from hydrogen, halo, hydroxy, amino, hydroxyamino, carboxy, nitro, guanidino, ureido, carbamoyl, cyano, trifluoromethyl, C 1 -C 6 -alkyl, C 3 -C 6 cycloalkyl, hydroxy, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkoxy, C 1 -C 6 alkoxycarbonyl, aryloxy, heteroaryloxy, C 1 -C 6 thioalkoxy, C 3 -C 6 thiocycloalkoxy, thioaryloxy, thioheteroaryloxy, nitro, amino, N-mono (C 1 -C 6 ) alkylamino, N,N-di(C 1 -C 6 ) alkylamino, formamido, amido, acetamido, hydroxylamino, C 1 -C 6 alkoxyamino, hydrazino, trifluoromethyl, trifluoromethoxy, alkenyl, alkynyl, aryl, heterocyclyl, fused aryl, fused heteroaryl and fused heterocyclyl.