Patent ID: 6916812

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof wherein n is 1; p is selected from an integer of 0 to 4; A is a bond or O; B is selected from the group consisting of a bond, O, S, NH and —N(C 1-4 )alkyl; R 1 and R 2 each are independently selected from the group consisting of hydrogen, (C 1-4 )alkyl, phenyl(C 1-4 )alkyl, imidazolyl(C 1-4 )alkyl, imidazolyl(C 1-4 )alkylcarbonyl, imidazolyloarbonyl, morpholinyl(C 1-4 )alkyl, piperidinyl(C 1-4 )alkyl, and di(C 1-4 )alkylamino(C 1-4 )alkyl; R 3 is selected from the group consisting of (C 1-8 )alkyl, Q is N or CR 8 , W is selected from the group consisting of a bond, NH, O, S, and C 6 H 5 CH; Y is selected from the group consisting of CHR 11 , NR 11 , O, and S; q is 0 or 1; r is 0 or 1; R 4 is selected from the group consisting of C 1-4 alkyl, C 3-7 cycloalkyl, phenyl, phenyl(C 1-4 alkyl, napthalenyl, benzodioxolyl, benzodioxanyl, pyridinyl, quinolinyl, thienyl, benzothienyl, dibenzothienyl, and phenoxathiinyl; and wherein said phenyl, thienyl and pyridyl are optionally substituted with one to three substituents each independently selected from halogen, trifluoromethyl, trifluoromethoxy, nitro, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 thioalkoxy, C 1-4 alkylcarbonyl, di(C 1-4 alkyl)amino, amino, carboxyl, phenyl, phenyl(C 1-4 )alkyl, phenyloxy, and phenylmethoxy; R 5 , R 6 , R 7 and R 8 each are independently selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, trifluoromethyl, nitro, XR 9 , phenyl, and phenyl(C 2-6 )alkenyl, wherein said phenyl is optionally substituted with one to two halogen or nitro groups; or any two variables selected from the group consisting of R 5 , R 6 , R 7 and R 8 , when attached to adjacent carbon atoms in a ring containing Q or Y and taken together can be —OCH 2 O—, —O(CH 2 ) 2 O—, —CH═CH—CH═CH—, or —CH═CH—N(R 11 )—; X is selected from the group consisting of NR 10 , O, and S(O) m , wherein m is 0, 1, or 2; R 9 is selected from the group consisting of hydrogen, C 1-8 alkyl, phenyl, phenyl(C 1-4 )alkyl, and wherein said phenyl and phenyl(C 1-4 )alkyl are optionally substituted with one to three substituents each independently selected from nitro, trifluoromethyl, halogen and C 1-4 alkyl; R 10 is selected from the group consisting of hydrogen, C 1-8 alkyl, and phenyl; and R 11 is selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkylsulfonyl, phenyl, phenyl(C 1-4 )alkyl, and phenylsulfonyl, wherein said phenyl, phenyl(C 1-4 )alkyl, and phenylsulfonyl are optionally substituted with one to three substituents each independently selected from C 1-4 alkyl or halogen.