Patent ID: 8496968

Claim:
A method for production of S/O type microcapsules in which a hydrophilic bioactive substance is polydispersed in a solid fat matrix, said method comprising the following steps (1) to (4) of: (1) emulsifying and dispersing a mixture of the solid fat and an aqueous solution containing the hydrophilic bioactive substance at a temperature of at least the melting point of the solid fat to obtain a W/O emulsion; (2) removing moisture in the W/O emulsion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O suspension; (3) adding the S/O suspension into an aqueous phase containing at least one selected from the group consisting of a surfactant (B), a thickening agent and a hydrophilic organic solvent, and permitting liquid droplet dispersion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O/W emulsion; and (4) cooling the S/O/W emulsion to lower than the melting point of the solid fat to harden the solid fat, and further removing the moisture at a temperature lower than the melting point of the solid fat.