Patent ID: 7332291

Claim:
A method of identifying an agent that modulates the binding between a Chemerin polypeptide and a ChemerinR polypeptide, said method comprising; contacting a ChemerinR polypeptide having the amino acid sequence of SEQ ID NO: 2 with a Chemerin polypeptide, said Chemerin polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 61 and SEQ ID NO: 47, in the presence or absence of a candidate modulator under conditions permitting the binding of said Chemerin polypeptide to said ChemerinR polypeptide; and measuring the binding of said Chemerin polypeptide to said ChemerinR polypeptide, wherein a decrease in binding in the presence of said candidate modulator, relative to the binding in the absence of said candidate modulator, identifies said candidate modulator as an agent that modulates the binding between said ChemerinR polypeptide and said Chemerin polypeptide.