Patent ID: 8871744

Claim:
A method for treating a subject having breast cancer, ovarian cancer, or pancreatic cancer in need of therapy thereof comprising administering to the subject a compound in an amount effective in reducing the migration or metastatic dissemination of mesenchymal tumor cells, said compound having the formula or a compound having the formula or a compound having the formula where R is an alkyl, Y=0 or 1, R1, R2 and R3 are independently hydrogen, alkyl, aryl, aralkyl or cycloalkyl, R4 is independently hydrogen or lower alkyl, n is an integer from 1 to 6, Z is a linker, X is 0 or 1, R5 is hydrogen or a pharmacologically active residue of an ALK5 inhibitor, with the proviso said compound contains at least one pharmacologically active residue of an ALK5 inhibitor; and pharmaceutically acceptable salts thereof, in combination with pharmaceutically acceptable carriers and diluents.