Patent ID: 8084583

Claim:
An isolated humanized antibody or fragment thereof that competes for binding to EGP-1 (TROP2) glycoprotein with a murine antibody comprising light chain complementarity-determining region (CDR) sequences CDR1 (KASQDVSIAVA, SEQ ID NO:28); CDR2 (SASYRYT, SEQ ID NO:29); and CDR3 (QQHYITPLT, SEQ ID NO:30) and heavy chain CDR sequences CDR1 (NYGMN, SEQ ID NO:31); CDR2 (WINTYTGEPTYTDDFKG, SEQ ID NO:32) and CDR3 (GGFGSSYWYFDV, SEQ ID NO:33), wherein said humanized antibody comprises human antibody framework region (FR) sequences and said FR sequences comprise at least one amino acid residue substituted by an amino acid residue selected from the group consisting of amino acid residues 38, 46, 68 and 91 of the murine antibody heavy chain variable region of SEQ ID NO:4 and residues 20, 85 and 100 of the murine antibody light chain variable region of SEQ ID NO:2.