Patent ID: RE39198

Claim:
A compound of the formula: wherein X is —O— or —S—; p is 1 or 2; Y is hydrogen, lower alkyl, hydroxy, chlorine, fluorine, bromine, iodine, lower alkoxy, trifluoromethyl, nitro, or amino, when p is 1; Y is lower alkoxy , hydroxy and halogen when p is 2 and X is —O—; (R 1 ) is R 20 , R 21 , or R 22 , wherein: R 20 is —(CH 2 ) n — where n is 2, 3, 4 or 5; R 21 is —CH 2 —CH═CH—CH 2 —, —CH 2 —C≡C—CH 2 —, —CH 2 —CH═CH—CH 2 —CH 2 , —CH 2 —CH 2 —CH═CH—CH 2 —, —CH 2 —C≡C—CH 2 —CH 2 —, or —CH 2 —CH 2 —C≡C—CH 2 —, the —CH═CH— bond being cis or trans; R 22 is R 20 or R 21 in which one or more carbon atoms of R 20 or R 21 are substituted by at least one C 1 -C 6 linear alkyl group, pheny group or where Z 1 is lower alkyl, —OH, lower alkoxy, —CF 3 , —NO 2 , —NH 2 or halogen; R is hydrogen, lower alkyl, lower alkoxy, hydroxyl, carboxyl, chlorine, fluorine, bromine, iodine, amino, lower mono or dialkylamino, nitro, lower alkyl thio, trifluoromethoxy, cyano, acylamino, trifluoromethyl, trifluoroacetyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, formyl, —C(═O)-alkyl, —C(═O)—O-alkyl, —C(═O)-aryl, —C(═O)-heteroaryl, —CH(OR 7 )-alkyl, —C(═W)-alkyl, —C(═W)-aryl, and —C(═W)-heteroaryl; or —CH( OR 7 )- alkyl; wherein alkyl is lower alkyl; aryl is phenyl or where in R 5 is hydrogen, lower alkyl, lower alkoxy, hydroxy, chlorine, fluorine, bromine, iodine, lower monoalkylamino, lower dialkylamino, nitro, cyano, trifluoromethyl, or trifluoromethoxy; heteroaryl is wherein Q 3 is —O—, —S—, —NH—, or —CH═N—; W is CH 2 or CHR 8 or N—R 9 ; R 7 is hydrogen, lower alkyl, or acyl; R 8 is lower alkyl; R 9 is hydroxy, lower alkoxy, or —NHR 10 ; and R 10 is hydrogen, lower alkyl, C 1 -C 3 acyl, aryl, —C(═)-aryl or —C(═O)-heteroaryl, where aryl and heteroaryl are as defined above; and m is 1, 2, or 3; all geometric, optical and stereoisomers thereof, or a pharmaceutically acceptable acid addition salt thereof.