Patent ID: 7417041

Claim:
A compound of the formula (Ia) or (Ib): or a pharmaceutically acceptable salt or tautomer thereof wherein: R 1 is an optionally substituted saturated, unsaturated, or aromatic C 3 -C 20 mono-, bi- or polycyclic ring optionally containing at least one heteroatom selected from the group consisting of N, O and S; each R 3 is independently selected from the group consisting of: hydrogen, halo, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, perhalo(C 1 -C 6 )alkyl, (C 5 -C 10 )heteroaryl, (C 5 -C 10 )heterocycle, (C 3 -C 10 )cycloalkyl, hydroxy, (C 1 -C 6 )alkoxy, perhalo(C 1 -C 6 )alkoxy, phenoxy, (C 5 -C 10 )heteroaryl-O—, (C 5 -C 10 )heterocycle-O—, (C 3 -C 10 )cycloalkyl-O—, (C 1 -C 6 )alkyl-S—, (C 1 -C 6 )alkyl-SO 2 —, (C 1 -C 6 )alkyl-NH—SO 2 —, nitro, cyano, amino, Ph(CH 2 ) 1-6 NH—, (C 1 -C 6 )alkylamino, [(C 1 -C 6 )alkyl] 2 -amino, (C 1 -C 6 )alkyl-SO 2 —NH—, amino(C═O)—, aminoSO 2 —, (C 1 -C 6 )alkyl-(C═O)—NH—, (C 1 -C 6 )alkyl-(C═O)—[((C 1 -C 6 )alkyl)-N]—, phenyl-(C═O)—NH—, phenyl-(C═O)—[((C 1 -C 6 )alkyl)-N]—, (C 1 -C 6 )alkyl-(C═O)—, phenyl-(C═O)—, (C 5 -C 10 )heteroaryl-(C═O)—, (C 5 -C 10 )heterocycle-(C═O)—, (C 3 -C 10 )cycloalkyl-(C═O)—, HO—(C═O)—, (C 1 -C 6 )alkyl-O—(C═O)—, H 2 N(C═O)—(C 1 -C 6 )alkyl-NH—(C═O)—, [(C 1 -C 6 )alkyl] 2 -N—(C═O)—, phenyl-NH—(C═O)—, phenyl-[((C 1 -C 6 )alkyl)-N]—(C═O)—, (C 5 -C 10 )heteroaryl-NH—(C═O)—, (C 5 -C 10 )heterocycle-NH—(C═O)—, (C 3 -C 10 )cycloalkyl-NH—(C═O)— and (C 1 -C 6 )alkyl-(C═O)—O—, where R 3 is optionally substituted by at least one substituent independently selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, halo, H 2 N—, Ph(CH 2 ) 1 - 6 NH—, and (C 1 -C 6 )alkylNH—; s is an integer from one to four; and R 4 and R 6 taken together with the atoms to which they are attached form a core fused heteroaromatic.