Patent ID: 8497273

Claim:
A compound of the formula (I) wherein D is a group of the formula C R 1 is H, C 1 -C 6 -alkyl, C 1 -C 6 -alkyl substituted by C 3 -C 6 -cycloalkyl, C 1 -C 6 -hydroxyalkyl, fluorinated C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, fluorinated C 3 -C 6 -cycloalkyl, C 3 -C 6 -alkenyl, fluorinated C 3 -C 6 -alkenyl, formyl, acetyl, propionyl or benzyl; R 2 , R 2′ , R 3 , R 4 and R 4′ are, independently of each other, H, methyl, fluoromethyl, difluoromethyl, or trifluoromethyl; A is 2,4-pyridylene, 3,5-pyridylene or 2,6-pyridylene, which is optionally substituted by one, two or three substituents selected from halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, fluorinated C 1 -C 4 -alkyl and fluorinated C 1 -C 4 -alkoxy; E is NR 7 , wherein R 7 is H or C 1 -C 3 -alkyl; Ar is a cyclic radical selected from the group consisting of phenyl, where the cyclic radical Ar carries 1 substituent R a in the 3-position of the phenyl ring; each R a is C 1 -C 6 -hydroxyalkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy, fluorinated C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, or fluorinated C 1 -C 6 -alkylthio; and physiologically tolerated acid addition salts thereof.