Patent ID: 8241622

Claim:
A vector set comprising at least two recombinant adeno-associated virus (rAAV) vectors, wherein a first rAAV vector has two inverted terminal repeats (ITRs) that are heterologous, and a second rAAV vector has two ITRs, at least one of which is homologous to and is in the same orientation as one of the ITRs in the first rAAV vector, wherein after introduction of the first rAAV vector and the second rAAV vector to a host or a host cell, a chimeric DNA molecule comprising nucleic acid sequences from the first rAAV vector and the second rAAV vector is formed at an increased efficiency relative to a control rAAV vector set comprising two rAAV vectors with four homologous ITRs, the two ITRs of the second rAAV vector may be homologous or heterologous, and wherein the heterologous ITRs are from different AAV serotypes.