Patent ID: 8013156

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein, Ar is selected from the following formulae wherein Ar is substituted with —X and —Y-L-Z, in an ortho relationship to each other, and said Ar is optionally substituted with up to four R 1 ; each R 1 is independently selected from —H, halogen, —CN, —NO 2 , —OR 3 , —N(R 3 )R 3 , —S(O) 0-2 R 3 , —SO 2 N(R 3 )R 3 , —CO 2 R 3 , —C(O)N(R 3 )R 3 , —N(R 3 )SO 2 R 3 , —N(R 3 )C(O)R 3 , —N(R 3 )CO 2 R 3 , —C(O)R 3 , —OC(O)R 3 , optionally substituted lower alkyl, optionally substituted aryl, optionally substituted lower arylalkyl, optionally substituted heterocyclyl, and optionally substituted lower heterocyclylalkyl; X is selected from the following formulae wherein R 4a is —C(O)N(R 3 )R 3 ; n=1 or 2; p=0 or 1; q is 1 to 3; M is −OR 3 or —N(R 3 )R 4 ; each R 2 is independently selected from —H, haloalkyl, —C 1-6 alkyl-N(R 3 )R 3 , —C 1-6 alkyl-OR 3 , —C 1-6 alkyl-CO 2 R 3 , and —C 1-6 alkyl-C(O)N(R 3 )R 3 ; each R 3 is independently selected from —H, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted lower arylalkyl, optionally substituted heterocyclyl, and optionally substituted lower heterocyclylalkyl; or two of R 3 , when taken together with a common nitrogen to which they are attached, form an optionally substituted five- to seven-membered heterocyclyl ring, said optionally substituted five- to seven-membered heterocyclyl ring optionally containing at least one additional heteroatom selected from N, O, S, and P; each R 4 is independently selected from R 3 , —SO 2 R 3 , —SO 2 N(R 3 )R 3 , —CO 2 R 3 , —C(O)N(R 3 )R 3 , and —C(O)R 3 ; Y-L-Z is selected from the following formulae, wherein g is zero to two; T is selected from absent, —N(R 3 )—, —S— and —O—; and each methylene between Y and T is optionally substituted; provided that when both Y and T are heteroatoms then g must be two; Y is —O— or optionally substituted —CH 2 —; R 5 is selected from —H, halogen, —CN, —NO 2 , —OR 3 , —N(R 3 )R 4 , —S(O) 0-2 R 3 , —SO 2 N(R 3 )R 3 , —CO 2 R 3 , —C(O)N(R 3 )R 3 , —N(R 3 )SO 2 R 3 , —N(R 3 )C(O)R 3 , —N(R 3 )CO 2 R 3 , —C(O)R 3 , optionally substituted lower alkyl, optionally substituted aryl, optionally substituted lower arylalkyl, optionally substituted heterocyclyl, and optionally substituted lower heterocyclylalkyl; and optionally two of R 5 , together with the atoms to which they are attached, form a second ring system fused with said five- to seven-membered ring system, said second ring system substituted with zero to four of R 5 .