Patent ID: 7601366

Claim:
A modified human catalase polypeptide having a carboxy-terminal peroxisome targeting signal (PTS) that has been modified from a native sequence of Lys-Ala-Asn-Leu (SEQ ID NO: 1) by replacement of SEQ ID NO: 1 in human catalase with a PTS comprising the sequence Xaa −3 Xaa −2 Xaa −1 , wherein, independently, Xaa −3 is Ser, Ala or Cys; Xaa −2 is Lys, Arg or His; and Xaa −1 Leu or Met, and wherein the replacement sequence comprises, to the amino-terminal side of Xaa −3 , n additional amino acid residues wherein n is an integer between 2 and about 17, the additional residues being numbered sequentially from Xaa −4 for the first additional residue to Xaa −20 for the seventeenth additional residue.