Patent ID: 7557121

Claim:
A compound of formula (I): or formula (I′): a stereoisomer thereof, or a pharmaceutically acceptable salt of said compound or stereoisomer, wherein: R 1 is het 1 optionally substituted with one or two halogen; (C 1 -C 4 )alkyl optionally substituted with halogen; (C 1 -C 4 )alkoxy optionally substituted with halogen; CN; morpholino; —NR 2 R 3 ; —(CH 2 ) n C(O)NR 2 R 3 ; —(CH 2 ) n C(O)O—R 4 ; —(CH 2 ) n —NR 5 —C(O)—R 4 ; —(CH 2 ) n —NR 5 —C(O)—NR 2 R 3 ; —SO 2 —NR 2 R 3 ; —SO 2 (C 1 -C 4 alkyl); —R 6 ; or —O—R 6 ; n is 0, 1, 2 or 3; R 2 and R 3 are taken separately and are independently hydrogen or (C 1 -C 4 )alkyl; or R 2 and R 3 are taken together with the N atom to which they are attached to form a 4-, 5-, 6- or 7-membered saturated heterocycle; R 4 and R 5 are taken separately and are independently hydrogen or (C 1 -C 4 )alkyl; R 6 is phenyl optionally substituted with halogen, (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy; A is a group of formula: wherein m is 2, 3, 4, 5 or 6; R 7 and R 8 are taken separately and are independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl or hydroxy(C 1 -C 6 alkyl); or R 7 and R 8 are taken together with the N atom to which they are attached to form a 4-, 5-, 6- or 7-membered saturated heterocycle wherein one ring —CH 2 group of said heterocycle is optionally replaced by NH, O, S, SO or SO 2 and wherein said saturated heterocycle is optionally and independently substituted with one or two (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, hydroxy(C 1 -C 4 )alkyl, hydroxy, C(O)O(C 1 -C 4 )alkyl, —C(O)—(C 1 -C 4 )alkyl-NH 2 , —C(O)NH 2 , halo, amino, (C 1 -C 4 )alkylamino or di[(C 1 -C 4 )alkyl]amino; or A is a group of formula: wherein p is 0, 1 or 2; Q is a 4-, 5- or 6-membered saturated heterocycle optionally substituted with hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, hydroxy(C 1 -C 6 alkyl), —(C 1 -C 4 )alkyl-COOH or —(C 1 -C 4 )alkyl-O—(C 1 -C 4 )alkyl-COOH; het 1 is a monocyclic or bicyclic heteroaromatic group comprising a 5- to 10-membered ring containing 1, 2, 3 or 4 heteroatoms selected from N, O and S.