Patent ID: 8598366

Claim:
A method of treating cancer in a subject, comprising administering to the subject an effective amount of a compound represented by formula (VA): or a pharmaceutically acceptable salt thereof, wherein: one of R i or R j is —H and the other is represented by the following formula: X 1 and X 2 are each, independently, CH; R 12 , R 13 and R 14 are each, independently, an alkyl, an alkenyl, an alkynyl, cyano, a haloalkyl, an alkoxy, a haloalkoxy, a halo, an amino, an alkylamino, a dialkylamino, —OP(O)(OR 7 ) 2 , —SP(O)(OR 7 ) 2 , nitro, an alkyl ester, or hydroxyl; R 7 , for each occurrence, is, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; R x is (R aa ) m , —R aa —C(O)(CH 2 ) n C(O)OH, —C(O)(CH 2 ) n C(O)OH, —C(O)YR z , (O)NH—R aa , or —(R aa ) q C(O)(Y 1 ); R y is —H or lower alkyl; R w is —H, an alkyl, an alkenyl, an alkynyl, cyano, a haloalkyl, an alkoxy, a haloalkoxy, a halo, an amino, an alkylamino, a dialkylamino, —OP(O)(OR 7 ) 2 , —SP(O)(OR 7 ) 2 , nitro, an alkyl ester, or hydroxyl; R aa is an amino acid residue or an amino acid residue analog; Y is CH 2 , O, or NH; R z is Alk-NH 2 , Alk-C(O)OH, Het, or Y 1 ; Alk is an optionally substituted alkylene; Het is an optionally substituted heteroalkyl; Y 1 is a water soluble polymer with a molecular weight less than 60,000 daltons; n is 1, 2, 3, or 4; m is an integer from 1 to 10; and q is 0 or 1.