Patent ID: 7476740

Claim:
A compound having the formula: Where: the 2-, 3-, 6-, or 7- positions are α or β; the compounds are racemic or 1R- or 1S- configured; X=O, NR 3 , NR 10 , N-L-Ch, CHR 3 , CHR 1 , CH 2 ,CHW 1 , CW 1 W 1 , CO, S, SO, SO 2 , NSO 2 R 3 , NSO 2 R 11 or CX 2 W, with the N, C, O or S atom being a member of the ring; L is a linking moiety comprising a chain of atoms containing 2 to about 6 carbon atoms; Ch is a tridentate or tetradentate chelating ligand that forms a neutral complex with technetium or rhenium; Ar=Phenyl or 1-naphthyl or 2-naphthyl, unsubstituted or substituted with one or more group selected from: —H; —Br; —CI; —I; —F; —OH; —CH 3 ; —OCH 3 ; —CF 3 ; —NO 2 ; —NH 2 ; —CN; —NHCOCH 3 , —C(CH 3 ) 3 , —C(CH 2 )CH 3 , (CH 2 ) q CH 3 , where q=0-6; —COCH 3 ; OAc; alkyl; alkenyl; alkynyl; allyl; isopropyl; isobutyl; wherein each substitutent can be at the 2, 3 and/or 4 position of the ring; W or X 2 =H, OH, OCH 3 , OAc, OCOR 4 , CH 3 , (CH 2 ) n CH 3 , R 4 ; W 1 =H, Br, CI, I, F, OH, OCH 3 , CF 3 , NO 2 , NH 2 , CN, NHCOCH 3 , N(CH 3 ) 2 , (CH 2 ) n CH 3 , COCH 3 , or C(CH 3 ) 3 ; R 3 =independently for each occurrence H, CH 3 , CH 2 Ar, (CH 2 ) n Ar, Ar, alkyl, alkenyl or alkynyl, cycloalkylmethyl, CH 2 CH=CHZ, (CH 2 ) n OH, (CH 2 ) n OR 4 , CH=CHZ; CH 2 J-Maleimide, CH 2 JN-Maleimide where J=CH 2 or O; (CH 2 ) n OCOCH 3 ; (CH 2 ) n OCOCH 2 OCH 3 ; (CH 2 ) n -morpholine; (CH 2 ) n -piperidine; (CH 2 ) n -piperazine; R 4 =CH 3 , CH 2 CH 3 , alkyl, alkenyl, alkynyl, allyl, isopropyl, isobutyl; R 5 =H, CH 3 , (CH 3 ) 2 , (CH 2 ) n SO 3 Q, alkyl, (alkyl) 2 , alkenyl, alkynyl, Ar, OCH 3 ; Q=K + , Na + , Li + , Ca 2+ , NH 4 + , RNH 3 + , or other pharmaceutically acceptable salts; R 10 =COR 4 , CH 2 OH, (CH 2 ) n OH, (CH 2 ) n OR 4 , (CH 2 ) n COOR 3 , (CH 2 ) n OCOR 3 ; R 2 =R 3 , OR 3 , isopropyl, isobutyl, OCOR 4 , OCOR 5 , W 1 , CH 2 R 3 , OCOR 3 , NHR 3 , COR 3 , (CH 2 ) n COOR 3 ; R 1 =H, (CH 2 ) n OH, (CH 2 ) n OR 4 , CR 3 =NOR 3 , CH=NR 3 ; COOR 8 , COR 8 , CONHR 8 , CONR 8 R 8 , CH 2 CH 3 , (CH 2 ) n CH 3 , CHCHR 9 , (CH 2 ) n CCR 9 , (CH 2 ) n COOR 8 , (CH 2 ) n OCOR 8 , OCOR 8 , C 3 HNOR 9 or C 2 N 2 OR 9 ; R 8 =R 3 , Br, CI, I, F, OH, OCH 3 , CF 3 , NO 2 , NH 2 , CN, NHCOCH 3 , N(CH 3 ) 2 , (CH 2 ) n CH 3 , COCH 3 , or C(CH 3 ) 3 ; C(CH 3 ) 3 , C 10 H 7 or C 10 H 6 W 1 ; R 9 =COOR 8 , CH 3 , (CH 2 ) n CH 3 , C 6 H 5 , C 6 H 4 Y, C 10 H 7 or C 10 H 6 W 1 ; n=0-4; m=0-4; and Z=F, CI, I or Br; wherein at least one of X, R 2 or R 1 comprises a COOR 3 group or a OCOR 3 group and wherein at least one R 3 group comprises an alkyl, cycloalkylmethyl, alkenyl or alkynyl group, said alkyl, cycloalkylmethyl, alkenyl or alkynyl group having from 10 to 20 carbon atoms.