Patent ID: 8202858

Claim:
A compound according to general formula 1a, or a compound which is a tautomer or a pharmaceutically acceptable salt thereof, wherein G is a group of formula 4a or 5a, wherein: A 3 and A 12 are independently —C(R 8 )═CH—; A 4 and A 13 are independently C(R 9 ); A 5 and A 14 are independently C(R 10 ); A 6 is NH or N-alkyl; A 7 and A 11 are C; A 8 is NH or N(CH 2 ) b R 11 ; A 9 is N; A 10 is CH; wherein the ring constituted by A 7 , A 8 , A 9 , A 10 and A 11 is aromatic; R 1 , R 2 and R 3 are independently selected among H, alkyl, O-alkyl, NO 2 , F, Cl and Br; R 4 is selected among H, alkyl, aryl, heteroaryl, —(CH 2 ) c —R 12 and R 7 is selected among H, alkyl, aryl, heteroaryl and —(CH 2 ) g —R 14 ; R 8 is selected among alkoxy, F, Cl, Br, CN, NH 2 , NO 2 , NH(alkyl), and N(alkyl) 2 ; R 9 and R 10 are independently H, alkyl, alkoxy, F, Cl, Br, CN, NH 2 , NO 2 , NH(alkyl), or N(alkyl) 2 ; R 11 is independently selected among H, alkyl, aryl, heteroaryl, F, OH, O-alkyl, S-alkyl, O-acyl, NH 2 , NH-alkyl, N(alkyl) 2 , NH-acyl, N(alkyl)-acyl, CO 2 H, CO 2 -alkyl, CONH 2 , CONH-alkyl, CON(alkyl) 2 , CN and CF 3 ; R 12 is selected among aryl, heteroaryl, F, OH, O-alkyl, S-alkyl, O-acyl, NH 2 , NH-alkyl, N(alkyl) 2 , NH-acyl, N(alkyl)-acyl, CO 2 H, CO 2 -alkyl, CONH 2 , CONH-alkyl, CON(alkyl) 2 , CN and CF 3 ; R 13 is selected among H, alkyl, aryl, heteroaryl, (CH 2 ) h —R 15 and Z—R 16 ; R 14 and R 15 are independently selected among H, alkyl, alkenyl, aryl, heteroaryl, F, OH, O-alkyl, S-alkyl, O-acyl, NH 2 , NH-alkyl, N(alkyl) 2 , NH-acyl, N(alkyl)-acyl, CO 2 H, CO 2 -alkyl, CO-alkyl, CO-aryl, CONH 2 , CONH-alkyl, CON(alkyl) 2 , alkenyl-CO 2 -alkyl, alkenyl-aryl, CN and CF 3 ; R 16 is selected among H, alkyl, alkenyl, aryl, heteroaryl, O-aryl, —(CH 2 ), R 17 , cyclopropyl-aryl and O—(CH 2 ) i —R 17 ; R 17 is selected among H, alkyl, aryl, heteroaryl, F, OH, O-alkyl, S-alkyl, O-acyl, NH 2 , NH-alkyl, N(alkyl) 2 , NH-acyl, N(alkyl)-acyl, CO 2 H, CO 2 -alkyl, CONH 2 , CONH-alkyl, CON(alkyl) 2 , CN and CF 3 ; W is selected among O and NH; X is selected among (CH 2 ) m , C(═O) and S(═O) j ; Y is selected among O, S, NH and N-alkyl; Z is selected among —C(═O), —C(═O)—O and —S(═O) k ; b and c are independently selected among 0, 1, 2 and 3; d and e are independently selected among 1 and 2; g, h and i are independently selected among 1, 2 and 3; j and k are independently selected among 1 and 2; and m and n are independently selected among 0, 1 and 2; wherein heteroaryl is pyridyl, 2-chloropyridyl, 4-methylpyridyl, thienyl, 3-chlorothienyl, 2,3-dimethylthiophenyl, furyl, 2-methylfuryl, pyrrole, N-methylpyrrole, oxazole, imidazole, pyrazole, or triazole; and wherein at least one of R 1 , R 2 , or R 3 is other than hydrogen.