Patent ID: 8207304

Claim:
An isolated antibody that binds to human interleukin 13 receptor alpha 1, wherein (a) the heavy chain variable region of said antibody comprises CDR1, CDR2 and CDR3 amino acid sequences as set forth in SEQ ID NOs:22, 15 and 23, respectively; and (b) the light chain variable region of said antibody comprises CDR1, CDR2 and CDR3 sequences as set forth in: (i) SEQ ID NOs:18, 19 and 24, respectively; (ii) SEQ ID NOs:18, 19 and 27, respectively; or (iii) SEQ ID NOs:18, 19 and 29, respectively, wherein the antibody has a K D for the interaction of the antibody with hIL-13Rα1 of less than 100 pM, and wherein the antibody antagonizes interleukin 13-induced human interleukin 13 receptor alpha 1-mediated eotaxin release from NHDF cells.