Patent ID: 6890928

Claim:
A compound or salt thereof, wherein: the compound corresponds in structure to Formula 122-1: A 1 is selected from the group consisting of —H, alkylcarbonyl, alkoxycarbonyl, carbocyclylcarbonyl, carbocyclyalkylcarbonyl, heterocyclylcarbonyl, heterocyclylalkylcarbonyl, carbocyclyloxycarbonyl, carbocyclylalkoxycarbonyl, aminoalkylcarbonyl, alkyl(thiocarbonyl), alkoxy(thiocarbonyl), carbocyclyl(thiocarbonyl), carbocyclylalkyl(thiocarbonyl), heterocyclyl(thiocarbonyl), heterocyclylalkyl(thiocarbonyl), carbocyclyloxy(thiocarbonyl), carbocyclylalkoxy(thiocarbonyl), and aminoalkyl(thiocarbonyl), wherein any member of such group optionally is substituted; and A 2 and A 3 , together with the carbon atom to which they are both attached, form an optionally-substituted heterocyclyl containing from 5 to 8 ring members; and E 1 is selected from the group consisting of —O—, —S(O) 2 —, —S(O)—, —N(R 1 )—, —C(O)—N(R 1 )—, —N(R 1 )—C(O)—, and —C(R 1 )(R 2 )—; and E 2 is selected from the group consisting of alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, and alkylcycloalkylalkyl, wherein any member of such group optionally is substituted; and E 2 forms a link of at least 2 carbon atoms between E 1 and E 3 ; and E 3 is carbocyclyl wherein the carbocyclyl has 5 or 6 ring members and optionally is substituted; and E 4 is selected from the group consisting of a bond, alkyl, alkenyl, —O—, and, —N(R 3 )—, wherein the alkyl or alkenyl optionally is substituted; and E 5 is selected from the group consisting of carbocyclyl and heterocyclyl, wherein the carbocyclyl or heterocyclyl optionally is substituted; and R 1 and R 2 are independently selected from the group consisting of —H and alkyl, wherein the alkyl optionally is substituted; and R 3 is selected from the group consisting of —H and alkyl, wherein the alkyl optionally is substituted; and neither R 1 nor R 2 forms a ring structure with E 2 , E 3 , E 4 , or E 5 .