Patent ID: 8680139

Claim:
A compound of the formula wherein X represents nitro or cyano; Y represents —S— or —O—; R 1 represents substituted aryl or substituted heteroaryl; R 2 represents (i) —CONR 4 R 5 , or (ii) —COR a or —CH(OH)R a , wherein R a represents an unsubstituted or substituted lower alkyl group; R 3 represents —H, lower alkyl, —NR′R″ or an unsubstituted or substituted aryl group wherein R′ and R″ independently represent —H, unsubstituted or substituted lower alkyl or unsubstituted or substituted phenyl; R 4 and R 5 each, independently, represent —H, an unsubstituted or substituted lower alkyl group, an unsubstituted or substituted cycloalkyl group, an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group, an unsubstituted or substituted heterocycle group, or R 4 and R 5 together with the nitrogen atom to which they are attached form an unsubstituted or substituted heterocycle group; R 6 represents —H or an unsubstituted or substituted alkyl (C 1 -C 6 ) group; said substituted lower alkyl group, and said substituted cycloalky group have 1-3 substituents selected from the group of —NR′R″, —OR′, oxo, unsubstituted or substituted phenyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycle, unsubstituted or substituted cycloalkyl, —SR 6 , —COOR 6 , —CONR 4a R 5a , —SOR 6 , —SO 2 R 6 , wherein R′ and R″ are as previously defined, and R 4a and R 5a independently represent —H, unsubstituted or substituted lower alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycle or R 4a and R 5a together with the nitrogen atom to which they are attached form an unsubstituted or substituted heterocycle group; said substituted aryl group, and said substituted phenyl group have 1-5substituents selected from the group of —NO 2 , unsubstituted or substituted lower alkyl, —NR′R″, —SO 2 R 6 , halogen, —OR 6 , heterocycle, —SO 2 NR′R″, —SR 6 , lower alkanoyl, —NRCOOR 6 , —NHC(═NH)—NH 2 , —NHCOR, —C(═NH)—NH 2 and —CN; said substituted heteroaryl group and substituted heterocycle group have 1-5 substituents selected from the group of unsubstituted or substituted lower alkyl, unsubstituted or substituted cycloalkyl, —OR 6 , —NR′R″, —COOR 6 , lower alkanoyl, oxo, —SO 2 R 6 ,—C(═NH)—NH 2 , _NHC(═NH)—NH 2 , —C(═NH)—NH 2 and —CN; and the stereoisomer, pharmaceutically acceptable salt and N-oxide forms of said compound; and with the proviso that said formula does not include the compounds selected from the group consisting of 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone; 1-[5-(4-chlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone.