Patent ID: 8680122

Claim:
A compound of Formula (I) wherein X is C 1-4 alkylene, wherein the C 1-4 alkylene is optionally substituted with one to three groups selected from C 1-3 alkyl and halo; wherein said C 1-3 alkyl is optionally substituted with one to three groups selected from oxo, amino, alkoxy, carboxy, nitro, hydroxyl, and halo; Y is S or S(O); R 1 is H or C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted with aryl; wherein said aryl is optionally substituted with C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo, nitro, hydroxyl, ethynyl, —CN, aryl, —SO 3 H, —C(O)OH, —C(O)O—C 1-4 alkyl, —C(O)NR′R″, —SR′, —OR′, —C(O)R′, —N(R′)(R″), —S(O) 2 —R′, and —S(O) 2 —N(R′)(R″), wherein R′ and R″ are independently selected from H, C 1-6 -alkyl, and aryl; R 2 is 0-3 members independently selected from halo, —OR 4 , —SR 4 , —S(O) 2 —R 4 , carboxy, nitro, hydroxyl, amido, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and amino C 1-6 alkyl, or aryl, wherein R 4 is selected from H, C 1-6 alkyl, and aryl; and wherein the C 1-6 alkyl is optionally substituted with aryl; wherein the C 2-6 alkenyl is optionally substituted with one to three groups selected from amino, alkoxy, carboxy, nitro, hydroxyl, and halo; wherein the amino is optionally substituted with C 1-6 alkyl, and aryl; wherein said C 1-6 alkyl is optionally substituted with aryl; wherein said aryl is optionally substituted with C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo, nitro, hydroxyl, ethynyl, —CN, aryl, —SO 3 H, —C(O)OH, —C(O)O—C 1-4 alkyl, —C(O)NR′R″, —SR′, —OR′, —C(O)R′, —N(R′)(R″), —S(O) 2 —R′, and —S(O) 2 —N(R′)(R″), wherein R′ and R″ are independently selected from H, C 1-6 -alkyl, and aryl; A is pyridine, said pyridine being connected to N(1) through a ring carbon atom adjacent to a ring nitrogen, and said pyridine being further optionally substituted with 1 or 2 members selected from C 1-4 alkyl, C 2-4 alkenyl, halo, —CN, aryl, —SO 3 H, —C(O)OH, —C(O)O—C 1-4 alkyl, —OR 4 , —SR 4 , —C(O)R 4 , —N(R 4 )(R 5 ), —C(O)—N(R 4 )(R 5 ), —S(O) 2 —R 4 , and —S(O) 2 —N(R 4 )(R 5 ), wherein R 4 and R 5 are independently selected from H, C 1-6 alkyl, and aryl; wherein the C 1-4 alkyl is optionally substituted with aryl; wherein the C 2-4 alkenyl is optionally substituted with one to three groups selected from amino, alkoxy, carboxy, nitro, hydroxyl, and halo; or an optical isomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salt thereof.