Patent ID: 8044045

Claim:
A method of treating a disorder of reduced motility of the gastrointestinal tract in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: R 1 is hydrogen, halo, hydroxy, C 1-4 alkyl, or C 1-4 alkoxy; R 2 is C 3-4 alkyl, or C 3-6 cycloalkyl; and W is selected from: (i) a group of formula (II): wherein X is: NC(O)R a , wherein R a is C 1-3 alkyl or tetrahydrofuranyl, wherein C 1-3 alkyl is optionally substituted with —OH or C 1-3 alkoxy; S(O) 2 ; or NS(O) 2 R b , wherein R b is methyl, optionally substituted with —OH, C 1-3 alkoxy, C 5-6 cycloalkyl, or —S(O) 2 —C 1-3 alkyl; (ii) a group of formula (III): wherein: R y is —OH or C 1-3 alkoxy; p is 0 or 1; n is 1 or 2; and Y is: NR c C(O)R d , wherein R c is hydrogen or C 1-3 alkyl and R d is C 1-3 alkyl, optionally substituted with —OH or C 1-3 alkoxy, or NR e S(O) 2 R f , wherein R e is hydrogen and R f is C 1-3 alkyl, optionally substituted with —OH, C 1-3 alkoxy, C 5-6 cycloalkyl, or —S(O) 2 —C 1-3 alkyl; and (iii) a group of formula (IV): wherein: R z is hydrogen, C 1-3 alkyl, or C 2-3 alkyl substituted with —OH or C 1-3 alkoxy; m is 1 or 2; q is 1 or 2, provided that the sum of m and q is not equal to 4; and Z is: NC(O)R g , wherein R g is C 1-3 alkyl, optionally substituted with —OH or C 1-3 alkoxy, S(O) 2 ; or NS(O) 2 R h , wherein R h is methyl, optionally substituted with —OH, C 1-3 alkoxy, C 5-6 cycloalkyl, or —S(O) 2 —C 1-3 alkyl; or a pharmaceutically-acceptable salt or stereoisomer thereof.