Patent ID: 8357679

Claim:
A hexafluoroisopropanol derivative having the general Formula I wherein B represents a five or six membered aromatic ring which is substituted at a carbon atom by a hexafluoroisopropanol moiety, the ring optionally comprising one or two nitrogens, sulphur or oxygen; n is 1 or 2; Z is CH 2 or CO; Y is CO, SO 2 , CH 2 or a bond; and can be of meta or para substitution pattern; A is a 6-membered aromatic ring optionally containing 1 or 2 nitrogen atoms; X is NR 4 , O or a bond; W is NH, O or CH 2 ; R 1 is (C 1-8 )alkyl, (C 3-8 )cycloalkyl or (C 3-8 )cycloalkyl(C( 1-4 )alkyl, each of the alkyl groups being optionally substituted with hydroxyl, hydroxymethyl, (C 1-3 )alkyloxy, cyano, halogen, CF 3 , NR 7 R 8 , NR 7 R 8 CO or R 9 OCO; or R 1 is 5- or 6-membered aromatic ring, optionally comprising 1-3 heteroatoms selected from O, S and N, the ring being optionally substituted by (C 1-3 )alkyl, (C 3-6 )cycloalkyl, (C 1-3 )alkyloxy, (C 1-3 )alkylsulfonyl, cyano, CF 3 , OCF 3 , halogen or R 9 OCO, and the ring being optionally linked to X via a (C 1-3 )alkylene group which is optionally substituted by hydroxyl; or R 1 is a 5- or 6-membered saturated or unsaturated heterocyclic ring, comprising 1 or 2 heteroatoms selected from NR 10 , O, S, SO and SO 2 , the ring being optionally substituted by (C 1-3 )alkyl, hydroxyl, oxo, NR 11 R 12 CH 2 or R 9 OCO, and the ring being optionally linked to X via a (C 1-3 )alkylene group which is optionally substituted by hydroxyl; or when X is NR 4 , R 1 , may together with R 4 and the N to which they are bonded form a 4-8 membered ring, which can be optionally substituted with hydroxyl or hydroxymethyl; R 2 optionally represents 1-3 substituents independently selected from (C 1-4 )alkyl, (C 1-4 )alkyloxy, CF 3 , OCF 3 and halogen; R 3 optionally represents 1-4 substituents independently selected from (C 1-4 )alkyl and (C 1-4 )alkyl substituted by OH or 1 or more halogens; or R 3 represents oxo or COOR 5 ; R 4 , when present is H or (C 1-3 )alkyl; R 5 , when present is H or (C 1-3 )alkyl; R 6 , when present is H or (C 1-3 )alkyl; R 7 and R 8 , when present, are independently H, (C 1-3 )alkyl or (C 3-5 )cycloalkyl; R 9 , when present, is H, (C 1-3 )alkyl or (C 3-5 )cycloalkyl(C 1-3 )alkyl; R 10 , when present, is H, (C 1-3 )alkyl or CO(C 1-3 )alkyl; R 11 , and R 12 , when present, are independently H or (C 1-3 )alkyl; or a pharmaceutically acceptable salt thereof.