Patent ID: 8796208

Claim:
A composition adapted for regenerating articular cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising: an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into a partial thickness defect or area of reduced volume of articular cartilage, wherein the infiltration suppressor agent is dexamethasone or a combination of dexamethasone and a cartilage-derived morphogenetic protein (CDMP); and a columnar growth promoting agent that promotes columnar growth of articular chondrocytes in a partial thickness defect or area of reduced volume of articular cartilage, wherein the columnar growth promoting agent is an osteoinductive bone morphogenetic protein (BMP); and wherein TGF-β is not present in said composition.