Patent ID: 7365076

Claim:
A compound of formula I: or a pharmaceutical salt thereof; wherein: W is H or OR 9 ; R 1 is phenyl, naphthyl, heteroaryl, benzyloxy, phenoxy, naphthyloxy, phenylethoxy, phenoxyethoxy, naphthylmethoxy, naphthylethoxy, phenylcarbonylamino, phenylaminocarbonyl, trifluoromethoxy, nitrile, alkenyl, alkynyl, sulfonyl, sulfonamido, alkanoyl, alkoxycarbonyl, alkylaminocarbonyl, or amino; where said phenyl, naphthyl, heteroaryl, benzyloxy, phenoxy, naphthyloxy, phenylethoxy, phenoxyethoxy, naphthylmethoxy, naphthylethoxy, phenylcarbonylamino, and phenylaminocarbonyl are optionally substituted with one or more R 2 ; R 2 is R 1 , H, or one or two substituents, the same or different selected from OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, methylenedioxy, trifluoromethoxy, nitrile, nitro, alkenyl, alkynyl, sulfonyl, or sulfonamido; R 5 is H, (C 1 -C 6 )alkyl, or trifluoromethyl; R 6 and R 7 are, independently, (C 1 -C 6 )alkyl or (C 3 -C 6 )cycloalkyl; or R 6 and R 7 can together form a ring of 4 to 8 carbon atoms; where any carbon atom of said R 6 and R 7 may be optionally replaced with N, S, or O; where R 6 and R 7 may be optionally substituted with R 5 or OH; where R 6 and R 7 can form a ring with 4 to 8 carbons fused onto a cycloalkyl ring of 4 to 6 carbon atoms; R 8 is H, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, benzyl (optionally substituted with benzyloxy or phenyloxy), naphthylmethyl (optionally substituted with one or more R 1 ), phenyl(C 2 -C 6 )alkyl (optionally substituted with one or more R 1 ), heteroarylmethyl (optionally substituted with R 1 ), cycloalkyl, cycloalkenyl, cycloalkylmethyl (where any carbon atom can be optionally replaced with N, S, or O and where said cycloalkylmethyl can be optionally substituted with OH, CF 3 , halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy), cycloalkenylmethyl (where any carbon atom can be optionally replaced with N, S, or O and where said cycloalkenylmethyl can be optionally substituted with OH, CF 3 , halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy); or R 5 and R 8 , together with the nitrogen atom to which R 8 is attached, form a ring optionally substituted with R 5 ; R 9 is H, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkyl-C(═O); t is 1, 2, or 3; and x is 1.