Patent ID: 6887867

Claim:
A compound of Formula I: wherein R 1 , R 2 , R 3 and R 4 are independently H, HO, R 13 Oâ€”, R 13 Sâ€”, halogen, C1-C3-alkyl, CF 3 , R 14 CO 2 â€”, R 14 COâ€” R 14 CONHâ€”, R 14 NHCOâ€”, R 14 NHCO 2 â€”, R 14 OCONHâ€”, R 14 O 2 Sâ€”, R 14 OSâ€”, or R 15 R 16 Nâ€”; or R 1 and R 2 , or R 2 and R 3 , or R 3 and R 4 taken together can be â€”SCH 2 Sâ€”, â€”SCH 2 Oâ€”, â€”OCH 2 Sâ€”, â€”SCH 2 CH 2 Sâ€”, â€”SCH 2 CH 2 Oâ€”, or â€”OCH 2 CH 2 Sâ€”; wherein one of R 1 , R 3 and R 4 must be C1-C3-alkoxy or C1-C3-alkylthio group; R 5 , R 6 , R 7 and R 8 are independently H, C1-C6-alkyl, C3-C6-alkenyl, C3-C6-cycloalkyl, phenyl or substituted phenyl, wherein the phenyl is substituted with one or two substituents, C1-C3-alkyl, halogen, R 13 Oâ€”, CF 3 â€”, R 14 O 2 Sâ€”, R 14 OSâ€”, R 14 COâ€”, R 14 CO 2 â€”, R 14 O 2 Câ€”, R 14 CONHâ€”, R 14 NHCOâ€”; or R 5 and R 6 taken together can be C3-C6-cycloalkyl; R 7 and R 8 taken together can be C3-C6-cycloalkyl; R 9 is R 15 R 16 NCOâ€”, R 15 R 16 NCSâ€”, R 17 OCOâ€”, R 15 COâ€”, R 15 R 16 NCH 2 COâ€”, R 14 O 2 Câ€”(CH 2 ) n â€”, R 15 R 16 NCOâ€”(CH 2 ) n â€”, NCâ€”(CH 2 ) n â€”, H C1-C6-alkyl, C3-C6-alkenyl, or C3-C6-cycloalkyl; or R 8 and R 9 taken together can be â€”(CH 2 ) m CH 2 (R 15 )NCOâ€”, â€”(CH 2 ) m CH 2 OCOâ€”, or â€”(CH 2 ) m CH 2 CH 2 COâ€”; R 10 and R 11 are independently H, R 15 R 16 Nâ€”, R 14 HNCOâ€”, or R 14 CONHâ€”; R 12 is H, halogen, HO, R 13 Oâ€”, R 15 R 16 Nâ€”, C1-C3-alkyl, CF 3 , R 14 CO 2 â€”, R 14 COâ€”, or R 14 CONHâ€”; R 13 is C1-C3-alkyl; R 14 is H or C1-C3-alkyl; R 15 and R 16 are independently H, C1-C10-alkyl, C1-C6-perfluoroalkyl, C3-C10-alkenyl, or C3-C6-cycloalkyl; or R 15 and R 16 taken together can be C3-C6-cycloalkyl; R 17 is C1-C6-alkyl, C3-C6-alkenyl, or C3-C6-cycloalkyl; n is 1 to 6; m is 0 to 2; and pharmaceutically acceptable salts thereof; wherein R 10 and H 11 cannot be both H.