Patent ID: 8575327

Claim:
A method for inhibiting expression of a polynucleotide sequence of hepatitis B virus in an in vivo mammalian cell comprising administering to said cell a double-stranded RNA effector molecule selected from the group consisting of: 1) a molecule consisting of the sequence of SEQ ID NO: 58 hybridized to a molecule with the reverse complement sequence of SEQ ID NO: 58; 2) a molecule consisting of the sequence of SEQ ID NO: 59 hybridized to a molecule with the reverse complement of SEQ ID NO: 59; and 3) a combination of the molecules of (1) and (2); wherein U is substituted for T, and wherein each effector dsRNA optionally comprises a single-stranded nucleotide sequence linking the sequence of SEQ ID NO: 58 or SEQ ID NO: 59 to its respective reverse-complement sequence.