Patent ID: 8058273

Claim:
A method of treating tumor diseases associated to the deregulation of the activity of histone deacetylases in a subject in need thereof, said tumor diseases selected among colon tumor, breast tumor, prostate tumor, lymphoma and cutaneous tumor, said method comprising administering to said subject, in an amount effective to treat said tumor diseases associated to the deregulation of the activity of histone deacetylases, a compound of formula (I) wherein: R 3 is chosen among hydrogen, alkoxyalkyl; Ar is an optionally substituted aryl or heteroaryl group; A is chosen among: wherein R 2 is chosen among hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, haloalkoxy, amino, aminoalkyl, alkylamino, (thio)carbonylamino, (thio)aminocarbonil, sulphonylamino, aminosulphonyl, (thio)acyl, (thio)acyloxy, (thio)alkoxycarbonyl, nitro and nitryl; R 1 is chosen among: wherein Y represents O, S, NH, CH 2 , NOH or NOR 5 where R 5 is an alkyl having from 1 to 4 carbon atoms.