Patent ID: 7414052

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: the dotted line represents an optional double bond between U and V or V and W; U is O; W is CH or CH 2 ; V is C(R 8 ) or C(R 8 ) 2 ; R 1 is, independently at each occurrence, alkyl, alkoxy, halo, CF 3 , OCF 3 , arylalkyloxy substituted with 0-3 R 9 , aryloxy substituted with 0-3 R 9 , aryl substituted with 0-3 R 9 , heteroaryl substituted with 0-3 R 9 , hydroxy, alkanoyloxy, nitro, nitrile, alkenyl, alkynyl, alkylsulfoxide, phenylsulfoxide substituted with 0-3 R 9 , alkylsulfone, phenylsulfone substituted with 0-3 R 9 , alkylsulfonamide, phenylsulfonamide substituted with 0-3 R 9 , heteroaryloxy substituted with 0-3 R 9 , heteroarylmethyloxy substituted with 0-3 R 9 , alkylamido, or phenylamido substituted with 0-3 R 9 ; or two adjacent R 1 also represent methylenedioxy; R 2 is aryl substituted with 0-3 R 1 or heteroaryl substituted with 0-3 R 1 ; R 3 is H, C 1 -C 4 alkyl substituted with 0-3 R 1 , C 3 -C 6 cycloalkyl, or phenyl substituted with 0-3 R 1 ; R 4 is, independently at each occurrence, H, C 1 -C 4 alkyl, arylalkyl, heteroarylmethyl, cycloheptylmethyl, cyclohexylmethyl, cyclopentylmethyl, or cyclobutylmethyl, or both R 4 groups, together with the nitrogen through which they are attached, form a heterocyclic ring of 4 to 6 ring atoms, where one carbon may be optionally replaced with N, O, S, or SO 2 , and where any carbon ring atom or additional N atom may be optionally substituted with C 1 -C 4 alkyl, F, or CF 3 ; R 5 is H or C 1 -C 4 alkyl; R 6 is H or C 1 -C 4 alkyl; R 7 is, independently at each occurrence, H, or C 1 -C 4 alkyl, or R 7 and R 4 together with the nitrogen to which R 4 is attached form a nitrogen-containing ring containing 3-6 carbon atoms; R 8 is, independently at each occurrence, H, C 1 -C 4 alkyl, C 3 -C 6 heteroalkyl, or aryl substituted with 0-3 R 1 ; R 9 is, independently at each occurrence, alkyl, alkoxy, halo, CF 3 , OCF 3 , hydroxy, alkanoyloxy, nitro, nitrile, alkenyl, alkynyl, alkylsulfoxide, alkylsulfone, alkylsulfonamide, or alkylamido; or two adjacent R 9 also represent methylenedioxy; n is an integer from 0 to 4; x is an integer from 1 to 2; and wherein 1-3 carbon atoms in ring A may optionally be replaced with N.