Patent ID: 7316819

Claim:
A method of making a dosage form for oral delivery of a peptide comprising the steps of: granulating a pH-lowering agent to form a first layer material; combining a peptide and at least one absorption enhancer to form a second layer material; adding said first layer material to a die and compressing said first layer material to create a first layer such that substantial mixing between the first layer material and the second layer material is prevented when the second layer material is added to the die; adding said second layer material to said die; compressing said first and said second layer materials together to form a lamination consisting of two layers wherein said first and said second layers interface with one another but wherein, at said interface, less than about 0.1% of the peptide contacts the pH-lowering agent to prevent substantial mixing between the first layer material and the second layer material to avoid interaction in the lamination between the pH-lowering agent and the peptide; coating said lamination with a water-soluble coating to form a coated lamination; and applying an enteric coating over said coated lamination to form a tablet, wherein said water-soluble coating substantially prevents said first layer material from contacting said enteric coating.