Patent ID: 8614311

Claim:
A double-stranded RNA compound having the following structure: 5′ (N)x-Z 3′ (antisense strand) 3′ Z′-(N′)y-z″ 5′ (sense strand) wherein each of N and N′ is a ribonucleotide which may be unmodified or modified, or is an unconventional moiety; wherein each of (N)x and (N′)y is an oligonucleotide in which each consecutive N or N′ is joined to the next N or N′ by a covalent bond; wherein Z and Z′ may be present or absent, but if present is independently 1-5 consecutive nucleotides covalently attached at the 3′ terminus of the strand in which it is present; wherein z″ may be present or absent, but if present is a capping moiety covalently attached at the 5′ terminus of (N′)y; wherein each of x and y is 19; wherein (N)x comprises at least five unmodified and at least five 2′-O-methyl sugar modified ribonucleotides in an alternating pattern beginning at the 3′ end and at least nine 2′-O-methyl sugar modified ribonucleotides in total and each remaining N is an unmodified ribonucleotide; wherein (N′)y comprises at least one unconventional moiety selected from the group consisting of a modified deoxyribonucleotide, an unmodified deoxyribonucleotide, a mirror nucleotide, and a nucleotide joined to an adjacent nucleotide by a 2′-5′ internucleotide phosphate bond; wherein the sequence of (N′)y is 5′ ACGUGAACUUGGAAAUUGA (SEQ ID NO:6898); and wherein the sequence of (N)x is 5′ UCAAUUUCCAAGUUCACGU 3′ (SEQ ID NO:6914).