Patent ID: 8288403

Claim:
A method of treating a disorder selected from the group consisting of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome, comprising administering a therapeutically effective amount of a compound of formula I wherein R 1 is a five or six membered heteroaryl group, optionally substituted by one or two Râ€²; Râ€² is lower alkyl; R 2 is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or cyano; Z is N, C, O or S; V is N, C(Râ€³), O or S; W is N, C(Râ€³), O, or S; Y is N or C; with the proviso that only one of Z, V or W is O or S; Râ€³ is hydrogen, lower alkyl, lower alkyl substituted by halogen or hydroxy, or C(O)Oâ€”R 4 ; L is a bond, â€”(CR 4 2 ) n â€”, â€”C(O)NR 4 â€”, â€”C(O)NR 4 CH 2 â€”, or â€”C(O)â€”; each R 4 is the same or different and is hydrogen or lower alkyl; R 3 is lower alkyl, lower alkoxy, lower alkyl substituted by hydroxy, cycloalkyl, or phenyl optionally substituted by one or more Râ€²â€³; Râ€²â€³ is halogen, cyano, lower alkyl, lower alkyl substituted by halogen or hydroxy, lower alkoxy or C(O)Oâ€”R 4 ; and n is 1, 2 or 3; or a pharmaceutically active acid addition salt thereof.