Patent ID: 8460882

Claim:
A method of diagnosing or monitoring the progression of prostate cancer in a subject, comprising detecting and/or quantifying at least one homeodomain containing transcription factor, or fragment thereof, in a urine sample from said subject; comparing the level of the at least one homeodomain containing transcription factor, or fragment thereof, present in the urine sample with the level of the at least one homeodomain containing transcription factor, or fragment thereof, in one or more control samples; and determining that the subject is afflicted with prostate cancer or that the subject's prostate cancer has progressed if the level of the at least one homeodomain containing transcription factor, or fragment thereof, in the urine sample from said subject is increased relative to the level in the control sample; wherein the at least one homeodomain containing transcription factor is an EN-2 peptide comprising SEQ ID NO:4; and wherein the fragment comprises at least ten consecutive amino acids from said SEQ ID NO:4, thereby diagnosing or monitoring the progression of prostate cancer in said subject.