Patent ID: 7294637

Claim:
A method of treating a mammal afflicted with or suffering from a drug addiction or a drug dependency for which a dopamine, serotonin, or norepinephrine receptor or transporter antagonist is indicated, comprising the step of: administering to a mammal in need thereof a therapeutically effective amount of a compound, wherein said compound is represented by A: wherein X represents C(R 3 ) 2 or C═O; Z represents C(R 3 ) 2 , C(O), or O; m is 1, 2, 3, 4 or 5; n is 1; p is 0, 1, 2, or 3; y is 0, 1, or 2; R represents H, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; R 1 represents; R 2 represents independently for each occurrence H, alkyl, fluoroalkyl, aryl, heteroaryl, or cycloalkyl; R 3 represents independently for each occurrence H, alkyl, aryl, OR 2 , OC(O)R 2 , CH 2 OR 2 , or CO 2 R 2 ; R 4 represents H, alkyl, cycloalkyl, aryl, heteroaryl, alkenyl, or OR; R 5 and R 6 are selected independently for each occurrence from the group consisting of H, alkyl, (CH 2 ) p Y, aryl, heteroaryl, F, OR 2 , and OC(O)R 2 ; or an instance of CR 5 R 6 taken together is C(O); R 8 and R 9 are selected independently for each occurrence from the group consisting of H, alkyl, (CH 2 ) p Y, aryl, heteroaryl, F, OR 2 , and OC(O)R 2 ; or an instance of CR 8 R 9 taken together is C(O); Y represents independently for each occurrence OR 2 , N(R 2 ) 2 , SR 2 , S(O)R 2 , S(O) 2 R 2 , or P(O)(OR 2 ) 2 ; a covalent bond may connect R 4 and an instance of R 5 or R 6 ; any two instances of R 5 and R 6 may be connected through a covalent bond; and the stereochemical configuration at any stereocenter of a compound represented by A is R, S, or a mixture of these configurations.