Patent ID: 8426441

Claim:
A compound of formula III: wherein: R is —R 1 , —R 1 —R 2 —R 3 , —R 1 —R 3 , or —R 2 —R 3 ; R 1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, and is optionally substituted with lower alkyl, hydroxy, lower alkoxy, halo, nitro, amino, cyano, or halo-lower alkyl; R 2 is —C(═O) or —C(═O)NH; R 3 is R 4 ; R 4 is lower alkoxy, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl, and is optionally substituted with lower alkyl, hydroxy, lower alkoxy, halo, nitro, amino, cyano, lower alkyl sulfonyl, heterocycloalkyl, or halo-lower alkyl; X is H, lower alkyl, hydroxy, hydroxy lower alkyl, or lower alkoxy; Y is H, —R 5 —R 6 , —R 6 or —R 5 —R 6 —R 7 ; R 5 is —NHC(═O), —NHC(═O)NR 5′ , —(CH 2 ) n C(═O)NR 5′ , —NH, or —(CH 2 ) n C(═O); n is 0, 1, or 2; and R 5′ is H, lower alkyl, lower alkoxy, or hydroxy lower alkyl; R 6 is lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl and is optionally substituted with one or more substituents selected from the group consisting of lower alkyl, hydroxy, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, halo, nitro, amino, cyano, or trialkylsilanyl; and R 7 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, hydroxy, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, halo, nitro, amino, oxo, cyano, or trialkylsilanyl, or is optionally connected to an aryl, heteroaryl, cycloalkyl, or heterocycloalkyl ring, such that the two rings form a bicyclic fused or spirocyclic ring system, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, hydroxy, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, halo, nitro, amino, oxo, cyano, or trialkylsilanyl; with the proviso that if R is C(═O)CH 3 and X is H, then Y is not CF 3 or H; or a pharmaceutically acceptable salt thereof.