Patent ID: 8586055

Claim:
A method of inducing an immune response in an individual infected with a retrovirus, the method comprising: administering antiretroviral therapy (ART); administering an immunogenic composition by electroporation into a muscle of the individual, wherein the immunogenic composition comprises one or more expression vectors that comprise nucleic acid sequences that encode: a Gag polypeptide linked to a β-catenin destabilizing sequence; a Gag polypeptide linked to a MCP-3 secretory polypeptide; an Env polypeptide; an Env polypeptide linked to an MCP-3 secretory polypeptide; a Pol polypeptide linked to a LAMP degradation signal; a polypeptide comprising Nef, Tat, and Vif antigens, where the polypeptide is linked to a LAMP degradation signal; an IL-15 receptor alpha polypeptide; and an IL-15 polypeptide linked to a secretory signal polypeptide; wherein the immunogenic composition is administered at least three times and administration of the immunogenic composition results in control of viremia upon cessation of ART.