Patent ID: 8211421

Claim:
A method for treating cancer of the liver, the method comprising: administering, to an organism in need of treatment, a recombinant modified vaccinia virus Ankara (MVA) expression vector comprising: a promoter operably-linked to a nucleotide sequence encoding a fusion protein comprising a CDase that exhibits cytosine deaminase activity at a higher level than that of a native CDase, wherein the CDase comprises the amino acid sequence of SEQ ID NO: 2; and a mutant UPRTase that exhibits uracil phosphoribosyltransferase activity at a higher level than that of a native UPRTase, wherein the mutant UPRTase comprises the amino acid sequence of SEQ ID NO: 1; wherein the recombinant modified vaccinia virus Ankara (MVA) expression vector is intratumorally administered.