Patent ID: 7141672

Claim:
A compound of formula I having the structure wherein R 1 is alkyl of 1–6 carbon atoms, cycloalkyl of 3–8 carbon atoms, thienyl, furyl, pyridyl, R 2 is hydrogen, alkyl of 1–6 carbon atoms, or aryl of 6 to 10 carbon atoms; R 3 and R 4 are independently halogen, hydrogen, alkyl of 1–12 carbon atoms, aryl of 6 to 10 carbon atoms, trifluoromethyl, alkoxyaryl of 7–14 carbon atoms, nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfonamide, —NR 7 (CH 2 ) m CO 2 H, arylsulfonamide, cycloalkyl of 3–8 carbon atoms, or heterocycle of 5 to 7 atom rings containing from 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur; R 5 is hydrogen, alkyl of 1–6 carbon atoms, —CH(R 8 )R 9 , —CH 2 (CH 2 ) n CO 2 R 10 , —C(CH 3 ) 2 CO 2 R 10 , —CH(R 8 )(CH 2 ) n CO 2 R 10 , —CH(R 8 )C 6 H 4 CO 2 R 10 , or —CH 2 -tetrazole; R 6 is hydrogen, alkyl of 1–6 carbon atoms, halogen, alkoxy of 1–6 carbon atoms, trifluoroalkyl of 1–6 carbon atoms or trifluoroalkoxy of 1–6 carbon atoms; R 7 is hydrogen or alkyl of 1 to 6 carbon atoms; R 8 is hydrogen, alkyl of 1–6 carbon atoms, aryl of 6–10 carbon atoms, arylalkyl of 7–15 carbon atoms, cycloalkyl of 3–8 carbon atoms, phthalic acid, R 9 is CO 2 R 12 , CONHR 12 , tetrazole, or PO 3 R 12 ; R 10 is hydrogen, alkyl of 1–6 carbon atoms, aryl of 6–12 carbon atoms, or aralkyl of 7–15 carbon atoms; R 11 is alkyl of 1 to 3 carbon atoms; R 12 is hydrogen, alkyl of 1–6 carbon atoms, aryl of 6–12 carbon atoms, or aralkyl of 7–15 carbon atoms; X is S; Y is O, NH, or S; Z is C, or N; Q is O, N, or S; m=1–3; n=1–6, or a pharmaceutically acceptable salt thereof.