Patent ID: 8623353

Claim:
An isolated cross-reactive antibody or a fragment thereof, which specifically inhibits or blocks mammalian Toll-like Receptor 2 (TLR2)-mediated immune cell activation by specifically binding to the C-terminal portion of the extracellular domains of at least human and murine TLR2, wherein the antibody or fragment thereof specifically binds through the variable regions of the heavy and light chains, wherein the heavy chain variable region comprises a complementarity determining region 1 (CDR1) region comprising the amino acid sequence Gly-Phe-Thr-Phe-Thr-Thr-Tyr-Gly (residues 58-65 of SEQ ID NO:6), a CDR2 region comprising the amino acid sequence Ile-Tyr-Pro-Arg-Asp-Gly-Ser-Thr (residues 83-90 of SEQ ID NO:-6) and a CDR3 region comprising the amino acid sequence Ala-Arg-Leu-Thr-Gly-Gly-Thr-Phe-Leu-Asp-Tyr (residues 129-139 of SEQ ID NO:6), and wherein the light chain variable region comprises a CDR1 region comprising the amino acid sequence Glu-Ser-Val-Glu-Tyr-Tyr-Gly-Thr-Ser-Leu (residues 47-56 of SEQ ID NO:7), a CDR2 region comprising the amino acid sequence Gly-Ala-Ser (residues 74-76 of SEQ ID NO:7) and a CDR3 region comprising the amino acid sequence Gln-Gln-Ser-Arg-Lys-Leu-Pro-Trp-Thr (residues 113-121 of SEQ ID NO:7).