Patent ID: 7314937

Claim:
A compound structurally represented by Formula I or pharmaceutically acceptable salts thereof wherein: X is NR 7 ; R 1 is hydrogen, C 1 -C 8 alkyl optionally substituted with 1 to 4 halogens, (CHR 5 ) n —C 3 -C 7 cycloalkyl, (CHR 5 ) n aryl, (CHR 5 ) n heteroaryl, or (CHR 5 ) n —O(CHR 5 ) n -aryl; R 2 is independently R 1 , or COR 1 , or cyclized with the attached nitrogen atom at the R 1 position to form a 4, 5, or 6 member carbon ring, wherein one of said carbons is optionally replaced by one of O, S, NR 1 or CO, or wherein the ring formed by R 1 and R 2 is optionally substituted one to two times with C 1 -C 4 alkyl; R 3 is independently C 3 -C 7 cycloalkylene, or C 1 -C 5 alkylene optionally substituted one or two times with C 1 -C 3 alkyl; R 4 is hydrogen, halogen, C 1 -C 4 alkyl, (CHR 5 ) n —C 3 -C 7 cycloalkyl, (CHR 5 ) n aryl, (CHR 5 ) n heteroaryl, (CHR 5 ) n —O(CHR 5 ) n -aryl or CO or cyclized with R 5 to from a cyclopropyl ring; R 5 is hydrogen, or C 1 -C 4 alkyl; R 6 is cyclized with the attached carbon atom at R 7 to form, including the fused benzene ring, a substituted tetrahydroisoquinoline ring; R 8 is hydrogen, a bond, C 1 -C 8 alkyl, —SO 2 R 9 , —CO 2 R 10 , —CO R 9 , —CONH R 10 ; R 9 is hydrogen, halogen, C 1 -C 8 alkyl optionally substituted with 1 to 4 halogens, C 3 -C 7 cycloalkyl, aryl, CH 2 aryl, heteroaryl, heterocycle, —O(CHR 5 ) n -aryl, —COR 1 , —CONR 1 R 2 , —SO 2 R 1 , —OR 1 , —N(R 1 ) 2 , —NR 1 R 2 , —CH 2 NR 1 R 2 , —CONR 1 R 2 —NHSO 2 R 1 , —NO 2 , —CO 2 R 1 , —SO 2 N(R 1 ) 2 , —S(O) n R 1 , —OCF 3 , —CH 2 SR 5 ; R 10 is hydrogen, halogen, C 1 -C 8 alkyl optionally substituted with 1 to 4 halogens, C 3 -C 7 cycloalkyl, aryl, CH 2 aryl, heteroaryl, heterocycle, —COR 1 , —CONR 1 R 2 , —SO 2 R 1 , —N(R 1 ) 2 , —NR 1 R 2 , —CH 2 NR 1 R 2 , —CONR 1 R 2 —CO 2 R 1 , —SO 2 N(R 1 ) 2 , —S(O) n R 1 , —CH 2 SR 5 ; and n is 0-4: provided the compound is not 1,2,3,4-tetrahydro-1-(4-hydroxyphenyl)-6-[2-(1-pyrrolidinyl)ethoxy]-2-(trifluoroacetyl)-isoquinoline, or 1,2,3,4-tetrahydro-5-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]-isoquinoline.