Patent ID: 7718412

Claim:
A method for making a sterile hemostatic composition, comprising: providing a biocompatible liquid having thrombin dissolved therein, combining said liquid comprising said thrombin with particles of a biocompatible polymer suitable for use in hemostasis and which is substantially insoluble in said liquid, mixing said liquid comprising said thrombin and said particles under conditions effective to form a continuous liquid phase comprising said thrombin and said particles substantially homogenously dispersed there through, thereby forming a substantially homogeneous hemostatic composition; and irradiating said substantially homogeneous hemostatic composition with an amount of ionizing radiation and for a time effective to provide a sterile, substantially homogeneous hemostatic composition, wherein the ratio of said continuous liquid phase and said particles is effective to provide said composition with hemostatic properties and wherein said thrombin maintains at least a portion of its enzymatic activity.