Patent ID: 6849648

Claim:
A compound of Formula II or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein: G 1 is (CH 2 ) m aryl, (CH 2 ) m substituted aryl, (CH 2 ) m heteroaryl, or (CH 2 ) m substituted heteroaryl, wherein E is O; A is NR 1 R 2 ; R 1 is hydrogen; R 2 is (CH 2 ) n aryl, (CH 2 ) n substituted aryl, (CH 2 ) n heteroaryl, or (CH 2 ) n substituted heteroaryl; m is 1; n is 1; R 5 , R 6 , and R 7 independently are hydrogen, halo, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, NO 2 , CN, CF 3 , or NR 9 R 10 , wherein R 9 and R 10 independently are hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, phenyl, or benzyl, or R 9 and R 10 are taken together with the nitrogen atom to which they are attached to complete a 3- to 7-membered ring having carbon atoms, the nitrogen atom bearing R 9 and R 10 , and 0 or 1 heteroatoms selected from N(H), N(CH 3 ), O, and S; wherein each aryl independently is phenyl or naphthyl; wherein each substituted aryl independently is phenyl or naphthyl substituted with from 1 to 3 substituents independently selected from selected from phenyl, cyano, CO 2 H, SO 2 NH 2 , CH 3 SO 2 , CH 3 S, alkyl, alkoxy, thio, thioalkyl, heteroaryl, heterocyclyl, halo, hydroxy, —COOR 9 , trifluoromethyl, nitro, amino of the formula —NR 1 R 2 , and T(CH 2 ) m QR 3 or T(CH 2 ) m CO 2 R 3 , wherein m is 1 to 6; T is O, S, NR 3 , N(O)R 3 , NR 1 R 2 Y, or CR 1 R 2 , Q is O, S, NR 3 , N(O)R 3 , or NR 1 R 2 Y, wherein R 1 and R 2 are described above, and R 9 is alkyl or substituted alkyl; wherein each heteroaryl independently is selected from pyridyl, benzothienyl, furanyl, indolyl, benzotriazolyl, indazolyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, [1,2,3]triazolyl, [1,2,4]triazolyl, benzofuranyl, thienyl, benzisoxazolyl, benzisothiazolyl, isoxazolyl, isothiazolyl, and oxazolyl; wherein each substituted heteroaryl is heteroaryl as defined above substituted with 1 or 2 substituents independently selected from alkyl, thio, and alkoxy.