Patent ID: 8268326

Claim:
A method of delaying progression of a breast tumor in a subject, said method comprising the step of administering to said subject a composition comprising a recombinant Listeria strain expressing a recombinant nucleotide sequence encoding a recombinant polypeptide comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA) protein fused to a listeriolysin (LLO) protein, an ActA protein, or a PEST sequence, wherein said recombinant nucleotide sequence encoding said fragment is selected from the group consisting of SEQ ID NOs 21, 22, or 23, whereby said subject mounts an immune response against a HMW-MAA-expressing pericyte of a vasculature of said tumor, whereby said subject mounts an immune response against said pericyte of said vasculature of said tumor, thereby delaying progression of a breast tumor in a subject.