Patent ID: 8129397

Claim:
A heterocyclic compound according to formula I wherein L is (CH 2 ) m , wherein m is 1 or 2; R 1 is C 1-4 alkyl, C 3-5 cycloalkyl, C 1-4 alkyloxy, halogen or CN, said C 1-4 alkyl, C 3-5 cycloalkyl and C 1-4 alkyloxy being optionally substituted with one or more halogens; R 2 is C 1-4 alkyl, C 3-5 cycloalkyl or C 1-4 alkyloxy, said C 1-4 alkyl, C 3-5 cycloalkyl and C 1-4 alkyloxy being substituted with a substituent selected from OH, C 1-4 alkyloxy and NR 9 R 10 ; X 1 , X 2 or X 3 are independently N or CR 3 , wherein R 3 is H or methyl; Y 1 is NR 4 , wherein R 4 is H or C 1-4 alkyl; Y 2 is CR 5 , wherein R 5 is H, C 1-4 alkyl, C 3-8 cycloalkyl or C 6-10 aryl; R 6 is H, C 1-4 alkyl or C 3-5 cycloalkyl; Y 3 is S; Y 4 is N; R 9 and R 10 are independently H or C 1-4 alkyl optionally substituted with a 5-9 membered heteroaryl ring system comprising 1-2 heteroatoms selected from O, S and N, or R 9 and R 10 together with the N to which they are bonded form a 4-6 membered saturated or unsaturated heterocyclic ring optionally comprising another heteroatom selected from O, S and N; or a pharmaceutically acceptable salt thereof.