Patent ID: 8323676

Claim:
An implantable medical device comprising: a device body and a coating disposed over the device body, the coating comprising: a drug reservoir layer comprising: a peptide or protein; a hydrophobic drug; and a polymer with a weight average molecular weight between about 10 to about 150 K Daltons; wherein the mass ratio of the peptide or protein to the hydrophobic drug is from about 1:0.1 to about 1:10; wherein the mass ratio of the protein or peptide to the polymer is from about 1:0.1 to about 1:10; wherein the cumulative release of the peptide or protein from the drug reservoir layer is between about 5% and about 50% at 24 hours and between about 10% and about 95% at 7 days; and wherein the polymer is a poly(ester-amide) or a poly(amide) that is of the following formula: wherein: i is an integer from 1 to 10, inclusive; j is an integer from 0 to 10, inclusive; k is an integer from 0 to 15, inclusive; x n is an integer from 0 to 100, inclusive; y m is an integer from 0 to 150, inclusive; p is an integer from 2 to about 4500; M w is from about 10,000 to about 1,000,000 Da; s i , t j , and v k represent the average mole fraction of each of A i , B j , and C k ; s i is a number from 0 to 0.5, inclusive; t j is a number from 0 to 0.5, inclusive; v k is a number from 0 to 0.5, inclusive; with the proviso that Σ i s i +Σ j t j +Σ k v k =1.0; Σ i s i =Σ j t j +Σ k v k =0.5; Σ i s i >0; Σ j t j >0 or Σ k v k >0; each A i has the chemical structure: each B j has the chemical structure and each C k has the chemical structure: wherein: each R bj , and R bj′ are independently selected from the group consisting of hydrogen and (C1-C4)alkyl, wherein: the alkyl group is optionally substituted with a moiety selected from the group consisting of —OH, —SH, —SeH, —C(O)OH, —NHC(NH)NH 2 , phenyl and or one or more of R bj and R bj′ may form a bridge between the carbon to which it is attached and the adjacent nitrogen, the bridge comprising —CH 2 CH 2 CH 2 —; each R ai , and each R cj are independently selected from the group consisting of (C1-C12)alkyl, (C2-C12)alkenyl, (C3-C8)cycloalkyl,-(CH 2 CH 2 O)CH 2 CH 2 — wherein q is an integer from 1 to 10, inclusive, and where z is 0, 1, or 2; subject to the restriction that at least one R ai is selected from the group consisting of where z is 0, 1, or 2; R dk is selected from the group consisting of —H, —OH, —O(C1-C20)alkyl, —O(C1C20)alkenyl and —O(CH 2 CH 2 O) w CH 2 CH 2 OR ek , wherein: w is an integer from 1 to 600, inclusive; R ek is selected from the group consisting of hydrogen, —C(O)CH═CH 2 and —C(O)C(CH 3 )═CH 2 ; and, each R ai , corresponds to the i th A i group, each R bj , R bj′ , and R cj corresponds to the j th B j group, and each R dk and optionally R ek correspond to the k th C k group.