Patent ID: 7314873

Claim:
A compound represented by chemical formula (I) or a pharmaceutically acceptable salt thereof: wherein B is —C 1-6 alkyl-, —C 0-3 alkyl-O—C 0-3 alkyl-, —C 0-3 alkyl-NH—C 0-3 alkyl-, —C 0-3 alkyl-S—C 0-3 alkyl-, —C 0-3 alkyl-PH—C 0-3 alkyl-. —C 0-3 alkyl-C(O)—C 0-3 alkyl-, or a direct bond; X is —C 1-6 alkyl-, —C 0-3 alkyl-O—C 0-3 alkyl-, —C 0-3 alkyl-NH—C 0-3 alkyl-, —C 0-3 alkyl-S—C 0-3 alkyl-, —C 0-3 alkyl-PH—C 0-3 alkyl-, —C 0-3 alkyl-C(O)—C 0-3 alkyl-, or a direct bond; R, R 71 , and R 72 each independently is hydrogen, OH, or C 1-4 alkyl, any alkyl optionally substituted with 1-6 groups, each group independently being —OH, —NH 2 , —NH—CH 3 , —N(CH 3 ) 2 , or halogen; n is 1, 2, 3, or 4; m is 0, 1, 2, 3, or 4; n+m is 2, 3, 4, 5, or 6; optionally, one of n CH 2 and one of m CH 2 are bridged by a —C 0-2 alkyl- linkage; E 1 is CH, N, or CR 6 ; E 2 is CH2, CHR, NH, NR, O, S, —S(O)—, or —S(O)2—; R 1 is halogen or C 1-4 alkyl; R 2 , R 3 , R 4 , and R 6 are each independently halogen, Cl4alkyl, or hydrogen; and R 5 is H, CH 3 , or CH 2 CH 3 .