Patent ID: 7754885

Claim:
A compound of formula I (tubulysin): wherein R, R 1 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , S, T, U, V, W, X, Y and Z have the following meanings: R=OR 1 R 1 =alkyl or aryl S=H U=H T=H or OR 4 R 4 =H, alkyl, aryl, COR 5 , P(O)(OR 6 ) 2 or SO 3 R 6 R 5 =alkyl, alkenyl, or aryl R 6 =H, alkyl or a metal ion V=OR 7 R 7 =COR 8 R 8 =alkyl, alkenyl or aryl W=H X=H, alkyl, alkenyl or CH 2 OR 9 R 9 =H, alkyl, alkenyl, aryl or COR 10 R 10 =alkyl, alkenyl, or aryl Y=free electron pair R 11 =alkyl, CF 3 or aryl and/or Z=CH 3 or COR 11 .