Patent ID: 7404945

Claim:
A method of evaluating a pharmacological effect of a medicine, comprising: administering to a subject the medicine together with a diagnostic reagent comprising any one of the following substances: a first compound which serves as a substrate for an enzyme contained in the medicine to be evaluated or for an enzyme generated from a prodrug contained in the medicine to be evaluated, or a pharmaceutically acceptable salt thereof; a second compound which serves as a substrate for an enzyme which is directly inhibited by an enzyme inhibitor contained in the medicine to be evaluated or by an enzyme inhibitor generated from a prodrug contained in the medicine to be evaluated, or a pharmaceutically acceptable salt thereof; a third compound which serves as a substrate for an enzyme whose activity is altered by the binding between a receptor and a receptor ligand contained in the medicine to be evaluated or a receptor ligand generated from a prodrug contained in the medicine to be evaluated, or a pharmaceutically acceptable salt thereof; or a labeled form of any one of the first, second, or third compound or any salts thereof; collecting a biological sample from the subject at least once; measuring the amount of the any one of the first to third compounds, a pharmaceutically acceptable salt thereof, or a metabolite thereof in the biological sample; and evaluating the pharmacological effect of the medicine based on the amount obtained in the measurement step.