Patent ID: 8809373

Claim:
A method of treating inflammation comprising contacting said receptor with a compound in an amount to treat said inflammation, wherein the compound is of the formula wherein one of W and V is N and the other is C; X is C 3 -C 8 cycloalkyl optionally substituted with one, two or three substituents independently selected from the group consisting of halo, alkyl, alkoxy, hydroxyl, cyano, nitro, amino, thiol, alkylthiol, haloalkyl, carboxy and alkylcarboxy; Y is selected from S, CH 2 , CH(CH 3 ), CH(OH), C(CH 3 )(OH), C(CH 3 ) 2 , C(—U(CH 2 ) n U—), C(O), NH, S(O), and S(O) 2 ; n can be an integer≧1; U is selected from CH 2 , S, and O; Z is selected from H, alkyl optionally substituted with halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, haloalkyl, carboxy, alkylcarboxy and carbamoyl, and cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl, wherein the ring portion of each is optionally substituted with one, two, three, four or five substituents independently selected from halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, haloalkyl, carboxy, alkylcarboxy and carbamoyl; and R 1 and R 2 are independently selected from H and alkyl optionally substituted with halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, haloalkyl, carboxy, alkylcarboxy and carbamoyl.