Patent ID: 6946272

Claim:
A catalytic antibody elicited by an antigen comprising the boron-containing hapten of formula I, wherein R 1 and R 2 may be the same or different and each is a side chain of a naturally occurring amino acid, a hydroxy containing side chain of a naturally occurring amino acid wherein said protecting group, a primary amido containing side chain of a naturally occurring amino acid wherein said amido group may be glycosylated, (C 2 –C 4 )alkyl, —CH 2 CH(CO 2 H) 2 , —(CH 2 ) 2 S(O)CH 3 , —(CH 2 ) 2 S(O) 2 CH 3 , —(CH 2 ) 3 NH 2 or —(CH 2 ) 3 ONHC(═NH)NH 2 ; V is O, CH 2 or NH; X is hydrogen, oxygen, amino, amino protected by a terminal amino protecting group, amino bonded to the C terminus of a naturally occurring amino acid to form a peptide bond, amino bonded to the C terminus of a peptide to form a peptide bond, alkene, (C 1 –C 9 )alkyl, (C 1 –C 9 )alkoxy or phenyl, phenoxy, cyclohexyl, phenylthio, phenylsulfinyl or phenylsulfonyl, wherein the aforementioned phenyl groups may be unsubstituted or mono-, di- or trisubstituted by halogen, (C 1 –C 4 )alkoxy or (C 1 –C 4 )alkoxycarbonyl; Y is hydrogen, carboxyl, carboxyl protected by a terminal carboxyl protecting group, a carbonyl bonded to the N terminus of a peptide through a peptide bond, (C 1 –C 9 )alkyl, (C 1 –C 9 )alkoxy, phenyl phenoxy, cyclohexyl, phenylthio, phenylsulfinyl or phenylsulfonyl wherein the aforementioned phenyl groups may be unsubstituted or mono-, di- or trisubstituted by halogen, (C 1 –C 4 )alkyl, (C 1 –C 4 )alkoxy or (C 1 –C 4 )alkoxycarbonyl; and wherein Z is O, CH 2 or NH; m is 0 or an integer from 1 to 10; n is 0 or 1; and q is 1 or 2 provided that if q is 2, then n=0 and there is no bond between X and the carbon bound to Z.