Patent ID: 8324261

Claim:
A histidine derivative represented by the following formula (I) or a pharmaceutically acceptable salt or hydrate thereof; wherein in the formula, R 1 is alkyl having 1 to 6 carbon(s) or benzyl which may be substituted with alkyl having 1 to 4 carbon(s) or halogen; R 2 is hydrogen or alkyl having 1 to 4 carbon(s); R 3 and R 4 are same or different and each is hydrogen, alkyl having 1 to 4 carbon(s) or phenyl which may be substituted with any one or two of alkyl having 1 to 6 carbon(s), alkoxy having 1 to 6 carbon(s), hydroxy, halogen, trifluoromethyl, nitro and cyano; and R 5 is an alkyl group having 5 to 8 carbons, carboxyl-alkyl having 1 to 4 carbon(s), alkoxy having 1 to 4 carbon(s)-carbonyl-alkyl having 1 to 4 carbon(s), 1-(cyclohexyloxycarbonyloxy)ethyl or one or two phenyl(s)-alkyl having 1 to 4 carbon(s) which may be substituted with alkyl having 1 to 6 carbon(s), alkoxy having 1 to 4 carbon(s) or halogen.