Patent ID: 8410261

Claim:
A double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human JC virus genome in a cell, wherein said dsRNA comprises a sense strand and an antisense strand that form a duplex structure, wherein said sense strand consists of uguuGAAuGuuGGGuuccuTsT (SEQ ID NO: 137) and said antisense strand consists of AgGAACCcAAcAUUcAAcATsT (SEQ ID NO:138), wherein each strand is modified to include a 2′-O-methyl ribonucleotide as indicated by a lower case letter “c” and “u” and g” and a phosphorothioate as indicated by a lower case letter “s” and wherein said dsRNA, upon contact with a cell expressing said JC virus, inhibits expression of said JC virus genome.