Patent ID: 7078180

Claim:
A method of diagnosing a cancer or a tumor in a mammal, said method comprising a) obtaining a biological sample from said mammal; b) contacting said sample with a composition comprising one or more ZEB specific detection reagent in an amount effective to permit detection and quantitation of a ZEB polypeptide, if present, in said sample, wherein said ZEB polypeptide is selected from the group consisting of SEQ ID NO: 10, the amino acid sequence encoded by nucleotides 2537 to 3473 of SEQ ID NO: 9, and the amino acid sequence encoded by nucleotides 481 to 1132 of SEQ ID NO: 9; c) determining from b) one or more of the amount and the sub-cellular location of said ZEB polypeptide; and d) determining from c) altered expression levels and/or localization of said ZEB polypeptide relative to normal control samples, thereby diagnosing a cancer or a tumor in said mammal.