Patent ID: 7888504

Claim:
A compound having the structure wherein in the ring represents one or two double bonds; R 1 is selected from the group consisting of aryl and heteroaryl; R 2 is selected from the group consisting of cycloalkyl and heterocyclyl; X is S; Y is CR 4 ; Z is selected from the group consisting of O, S, S(O), S(O) 2 , and NR 5a ; R 4 and R 5 are the same or different and are independently selected from the group consisting of H, halogen, alkyl, aryl, heteroaryl, alkylaryl, and alkylheteroaryl R 5a is selected from the group consisting of H, alkyl, and aryl; R 6 and R 7 are the same or different and are independently selected from the group consisting of H, halogen, and alkyl; R 8 is selected from the group consisting of optionally substituted aryl, and optionally substituted heteroaryl; m is 0; n is 0, 1, 2, or 3; stereoisomers thereof, or a pharmaceutically acceptable salt thereof; with the proviso that where Z is S, S(O) or S(O) 2 , then R 8 must be substituted with a substituent selected from 1) —C(O)NR f R g ; 2) —NHC(O)OR h ; 3) —OC(O)NHR h ; 4) alkoxy; 5) tetrazolyl; and 6) SO 2 NR i R j ; where R f and R g are independently selected from H, alkyl and aryl or R f and R g can be taken together with the N atom to which they are attached to form a 3 to 7 membered heterocyclo ring; R h is alkyl or aryl; and R i and R are independently selected from H, alkyl and aryl; provided that at least one of R i and R j is other than H.