Patent ID: 7259164

Claim:
A compound having the Formula I wherein: n is 0, 1, 2, or 3; R 1 is independently chosen from hydroxy, nitro, cyano, amino, amido, sulfonamido, halo, —CHO, —COOH, C 1 -C 6 alkyl, such as C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 7 cycloalkyl, mono- and di(C 1 -C 6 alkyl)amino, mono- and di(C 1 -C 6 alkyl)amino(C 1 -C 6 alkyl), C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, (C 1 -C 6 alkoxy)C 1 -C 6 alkoxy, amino(C 1 -C 6 alkyl), C 1 -C 6 alkylthio, oxo, heteroaryl, and —(C═O)R 13 wherein R 13 is chosen from C 1 -C 6 alkyl, such as C 3 -C 6 cycloalkyl, C 7 cycloalkyl, C 2 -C 6 alkanoyl, C 1 -C 6 alkoxycarbonyl, heterocycloalkyl, phenyl, and heteroaryl; R 3 is chosen from hydrogen, optionally substituted C 1 -C 6 alkyl, such as optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 7 cycloalkyl, optionally substituted (heterocycloalkyl)C 0 -C 4 alkyl, and optionally substituted (heteroaryl)C 0 -C 4 alkyl; A is 1, 2, 3, or4; Z 1 is —CR 4 R 5 — wherein each R 4 and R 5 is independently chosen from hydrogen, C 1 -C 6 alkyl, and halo; Z 2 is a divalent linking group chosen from para-phenylene, meta-phenylene, ortho-phenylene, and naphthylene, said divalent linking group being substituted with one group R 2 —Q—, where Q is wherein R 6 and R 7 are each independently chosen from hydrogen; C 1 -C 6 alkyl; optionally substituted phenyl, and optionally substituted heteroaryl; X is O, S or —CH 2 —; and R 2 is chosen from optionally substituted C 1 -C 7 alkyl, such as optionally substituted C 3 -C 7 cycloalkyl, optionally substituted (C 3 -C 7 cycloalkyl)C 1 -C 7 alkyl, optionally substituted heterocycloalkyl, optionally substituted (heterocycloalkyl)C 1 -C 2 alkyl, optionally substituted (C 1 -C 6 alkoxy)C 0 -C 6 alkyl, optionally substituted (C 1 -C 6 alkoxy)C 1 -C 6 alkoxy, optionally substituted phenyl, and optionally substituted heteroaryl.