Patent ID: 8367320

Claim:
A method for validating an expression modulating analysis or assay using an apoptosis inducing expression modulating compound as a positive control, the method comprising: introducing the apoptosis inducing expression modulating compound as the positive control into cells of the expression modulating analysis or assay to induce apoptosis in the cells, wherein the apoptosis inducing expression modulating compound is capable of targeting a species specific repetitive element present in untranslated regions of protein coding gene transcripts of more than 50 different genes, wherein the apoptosis inducing expression modulating compound is an RNAi modulating compound that is capable of silencing the expression of the target genes via RNAi, and wherein the RNAi modulating compound has one or more of the following characteristics: a) it is a siRNA, miRNA or a shRNA; or b) it is expressed by a vector; and analyzing the cells into which the apoptosis inducing expression modulating compound has been introduced to detect whether apoptosis has been induced in said cells, wherein detection of apoptosis in said cells constitutes the positive control that validates the expression modulating analysis or assay.