Patent ID: 8575222

Claim:
A method of treating muscular dystrophies comprising administering to a subject a nitric oxide releasing compound of formula (Ia) M-X—Y—ONO 2 (Ia) or enantiomers or diastereoisomers thereof, wherein in the general formula (Ia), M, X and Y have the following meanings: M is a residue selected from the group consisting of: X is —O—, —S— or —NR 1 —, wherein R 1 is H or linear or branched C 1 -C 6 alkyl; Y is a bivalent radical having the following meanings: a)—straight or branched C 1 -C 20 alkylene being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO 2 and T, wherein T is —OC(O)(C 1 -C 10 alkyl)-ONO 2 or —O(C 1 -C 10 alkyl) ONO 2 ; C 5 -C 7 cycloalkylene group optionally substituted with linear or branched C 1 -C 10 alkyl group; wherein n is an integer from 0 to 20; n 1 is an integer from 1 to 20 wherein when Y is selected from the bivalent radicals mentioned under b) and c) then the —ONO 2 group of formula is bound to —(CH 2 ) n 1 ; wherein X 1 =—OCO— or —COO— and R 2 is H or CH 3 ; na is an integer from 1 to 20; n 2 is an integer from 0 to 2; wherein: Y 1 is —CH 2 —CH 2 —(CH 2 ) n 2 —; or —CH═CH— (CH 2 ) n 2 ; X 1 , na, n 2 and R 2 are as defined above; wherein: na and R 2 are as defined above, R 3 is H or —COCH 3 ; wherein when Y is selected from the bivalent radicals mentioned under d)-f) then the —ONO 2 group of formula (I) is bound to —(CH 2 ) na ; wherein when X is —NR 1 —, wherein R 1 is as above defined Y cannot be f); and wherein X 2 is —O— or —S—; n 3 is an integer from 1 to 6 and R 2 is as defined above.