Patent ID: 7217701

Claim:
A boron compound represented by the formula (I) or nontoxic salts thereof, wherein R 1 is (1) a hydrogen atom; (2) —(CH 2 ) n —NR 2 R 3 , wherein n represents an integer of 1 to 3, R 2 and R 3 each independently represent, a hydrogen atom, C1–4 alkyl, mono-cyclic C5–6 carboring, or C1–4 alkyl substituted with mono-cyclic C5–6 carboring, wherein the carbon atom of —(CH 2 ) n — may be substituted with 1 to 2 R 4 , and the carboring may be further substituted with 1 to 2 R 7 , R 4 is (a) C1–8 alkyl, (b) carboxyl, (c) C1–4 alkoxycarbonyl, (d) keto, (e) mono-cyclic C5–6 carboring, (f) guanidino(C1–2)alkyl, (g) C1–6 alkyl substituted with mono-cyclic C5–6 carboring, (h) C1–2 alkyl substituted with 4-chlorophenoxy, or (i) C1–4 alkyl substituted with di(C1–4 alkyl)amino; (3) C1–6 alkyl or C2–6 alkenyl substituted with mono-cyclic C5–6 carboring, wherein the carboring may be substituted with 1 to 5 R 7 , and the C1–6 alkyl or C2–6 alkenyl may be further substituted with 1 to 2 R 10 ; R 10 represents C1–4 alkyl or C2–4 alkenyl; (4) —CHR 5 R 6 , wherein R 5 and R 6 independently represent (i) mono-cyclic C5–6 carboring, or (ii) C1–6 alkyl or C2–6 alkenyl substituted with mono-cyclic C5–6 carboring, wherein the carboring may further be substituted with 1 to 5 R 7 ; or R 7 represents (a) C1–4 alkyl, (b) C1–4 alkoxy, (c) a halogen atom, (d) —CF 3 , (e) nitro, (f) mono-cyclic C5–6 carboring, (g) C1–4 alkyl substituted with mono-cyclic C5–6 carboring, (h) amino, (i) —NHCO(C1–4 alkyl), or (j) C1–4 alkoxycarbonyl; G represents Cyc1; Cyc1 represents mono- or bi-cyclic C5–10 carboring, wherein the carboring may be substituted with 1 to 5 R 8 ; Cyc2 represents mono- or bi-cyclic C5–10 carboring substituted with wherein the carboring may be substituted with 1 to 4 R 9 ; Cyc3 and Cyc4 independently represents mono- or bi-cyclic C5–10 carboring which may be substituted with 1 to 2 R 7 ; R 8 and R 9 independently represents (a) C1–4 alkyl, (b) C2–4 alkenyl, (c) C1–4 alkoxy, (d) a halogen atom, (e) —CF 3 , (f) C1–4 alkylthio, (g) amino, (h) (C1–4 alkyl)amino, (i) di(C1–4 alkyl)amino, (j) formyl, (k) phenyl, (l) phenoxy, (m) hydroxy(C1–2)alkyl, (n) (mono- or bi-cyclic C5–10 carboring)-O—(C1–2)alkyl, (o) C1–4 alkoxycarbonylvinyl, (p) C1–2 alkyl substituted with a group selected from —O—(C1–2 alkylene)-phenyl, wherein phenyl may be substituted with 1 to 3 C1–4 alkoxy, —O—CONH-phenyl, wherein phenyl may be substituted with 1 to 3 C1–4 alkyl, nitro or C1–4 alkoxycarbonyl, or —O—CONH—(C1–4) alkyl, wherein alkyl may be substituted with 1 to 3 C1–4 alkyl, carboxyl or C1–4 alkoxycarbonyl, (q) phenylthio, (r) —CON(C1–4 alkyl) 2 , (s) —SO 2 N(C1–4 alkyl) 2 , (t) C1–4 alkoxy(C1–2)alkyl, or (u) C1–4 alkoxycarbonyloxy(C1–2)alkyl, in R 8 and R 9 , the carboring and phenyl may be substituted with 1 to 2 R 7 ; p represents an integer of 1 to 4; q represents an integer of 1 to 4; and E represents a single bond.