Patent ID: 8063039

Claim:
A method for treating pain, migraine, inflammation, gastrointestinal tract disorders, disorders of the genito-urinary tract, ophthalmic diseases or obesity in a subject, said method comprising administering to said subject an effective amount of a compound of general formula I and the pharmaceutically acceptable salts thereof, wherein m is an integer from 1 to 3; X is methylene, oxygen, sulphur or a NR 6 group; R 1 is a straight or branched C 1 -C 8 alkyl or C 3 -C 8 alkenylene or C 3 -C 8 alkynylene chain, optionally substituted with CF 3 , phenyl, phenoxy or naphthyl or phenyl, the aromatic 3-(4-Benzyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Benzyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylpentoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenylallyloxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-2-chloro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-fluoro-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-bromo-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-methoxy-benzylamino)-pyrrolidin-2-one; 3-(4-Phenoxyethoxy-3-methyl-benzylamino)-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-bromo-benzylamino]-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-methoxy-benzylamino]-pyrrolidin-2-one; 3-[4-(Naphthalen-1-ylmethoxy)-3-methyl-benzylamino]-pyrrolidin-2-one; 3-(4-Pentyloxy-3-bromo-5-methoxy-benzylamino)-pyrrolidin-2-one; rings optionally substituted by one or more C 1 -C 4 alkyl, halogens, trifluoromethyl, hydroxy or C 1 -C 4 alkoxy groups; R 2 , R 3 are independently hydrogen, aC 1 -C 3 alkyl chain, halogen, trifluoromethyl, hydroxy or C 1 -C 4 alkoxy groups; and R 4 , R 5 , R 6 are independently hydrogen or C 1 -C 6 alkyl.