Patent ID: 8304539

Claim:
A compound according to formula I an enantiomer, diastereomer, tautomer, or a pharmaceutically-acceptable salt thereof, wherein: Z is selected from heterocyclo, heteroaryl, and cyano; J 1 is an O, S, SO or SO 2 ; R 1 , R 2 , R 4 , R 5 , R 7 , and R 8 are the same or different and at each occurrence are independently selected from (i) hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, nitro, cyano, OR 12 , —NR 12 R 13 , —C(═O)R 12 , —CO 2 R 12 , —C(═O)NR 12 R 13 , —OC(═O)NR 12 ,R 13 , —OC(═O)R 12 , —NR 12 C(═O)R 13 , —NR 12 C(O)OR 13 , —NR 12 C(S)OR 13 , —S(O) p R 16 , NR 12 SO 2 R 16 , dialkylaminoalkoxy, alkoxyalkyloxyalkyloxy, SO 2 NR 12 R 13 , cycloalkyl, cycloalkenyl, cycloalkynyl, heterocyclo, aryl, and heteroaryl; and/or (ii) where possible, together with the atoms to which they are attached, each one of R 1 , R 2 , R 4 , R 5 , R 7 , and R 8 is taken together with any one of R 1 , R 2 , R 4 , R 5 , R 7 , and R 8 located on an adjacent atom to form a fused ring; R 9 and R 10 are the same or different and at each occurrence are independently selected from (i) hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, nitro, cyano, OR 14 , NR 14 R 15 , C(═O)R 14 , CO 2 R 14 , C(═O)NR 14 R 15 , —O—C(═O)R 14 , NR 14 C(═O)R 15 , NR 14 C(═O)OR 15 , NR 14 C(═S)OR 15 , S(O) p R 17 , NR 14 SO 2 R 17 , SO 2 NR 14 R 15 , cycloalkyl, cycloalkenyl, heterocyclo, aryl, and heteroaryl; or (ii) together with the atom to which they are attached, R 9 and R 10 are taken together to form a carbonyl, alkenyl, substituted alkenyl, cycloalkyl, cycloalkenyl, or heterocyclo group; R 11 at each occurrence is independently selected from hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, heterocyclo, and cycloalkyl; R 12 , R 13 , R 14 , and R 15 are the same or different and at each occurrence are independently selected from (i) hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, and heterocyclo; or (ii) where possible R 12 is taken together with R 13 , and/or where possible R 14 is taken together with R 15 to form a heteroaryl or heterocyclo ring; R 16 and R 17 are the same or different and at each occurrence are independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, and heterocyclo; and p is 0, 1 or 2.