Patent ID: 7572619

Claim:
A human factor VIII mutein, the sequence of which corresponds to the mature wild-type factor VIII sequence shown in SEQ ID NO:2, wherein the B-domain including residues Ser741to Arg 1648 has been deleted and replaced by an Arg-rich linker peptide consisting of the sequence of SEQ ID NO: 9, the sequence optionally consisting of up to three point mutations selected from the group consisting of: (a) Val at position 162 has been replaced by a neutral amino acid residue selected from Gly, Ala, Leu, Ile, Met and Pro; (b) Ser at position 2011 has been replaced by a hydrophilic amino acid residue selected from Asn, Thr and GIn; and (c) Val at position 2223 has been replaced by an acidic amino acid residue selected from GIu and Asp, wherein said factor VIII mutein has blood coagulation activity.