Patent ID: 7241737

Claim:
A urotensin-II polypeptide antagonist having the formula: (R 1 ) a -AA 1 -cyclo[AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -Cys]-AA 7 -R 2 wherein AA 1 is the L isomer of an aromatic amino acid; AA 2 is the L or D isomer of Cys; AA 3 is an L isomer of an aromatic amino acid; AA 4 is L-Trp; AA 5 is the L or D isomer of Lys or Orn; AA 6 is the L or D isomer of Val, Thr, Leu, Ile, tert-Leu, Abu, Nle, or an aromatic amino acid; AA 7 is the L or D isomer of Val, Thr, Leu, Ile, tert-Leu, Abu, Nle, or an aromatic amino acid; R 1 is H, (C 2 -C 6 )lower alkyl, lower alkanoyl, or a lower acyl; a is 2; and R 2 is OH, OR 3 , N(R 3 ) 2 or NHR 3 , where R 3 is H, a lower alkyl, or arylalkyl; or a pharmaceutically acceptable salt of said polypeptide.