Patent ID: 7566719

Claim:
A compound represented by the formula I: or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein A is (a) hydrogen; (b) —(C═O)—O—R 1 , wherein R 1 is hydrogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, substituted C 1 -C 6 alkynyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; (c) —(C═O)—R 2 , wherein R 2 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, substituted C 1 -C 6 alkynyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, alkylamino, dialkylamino, arylamino, diarylamino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; (d) —C(═O)—NH—R 2 , wherein R 2 is previously defined; (e) —C(═S)—NH—R 2 , wherein R 2 is previously defined; or (f) —S(O) 2 —R 2 , wherein R 2 is previously defined; G is (a) —OH, (b) —O—(C 1 -C 12 alkyl), (c) —NHS(O) 2 —R 1 , wherein R 1 is previously defined; (d) —(C═O)—R 2 , wherein R 2 is previously defined; (e) —(C═O)—O—R 1 , wherein R 1 is previously defined; or (f) —(C═O)—NH—R 2 , wherein R 2 is previously defined; L is absent X and Y taken together with the carbon atoms to which they are attached form a cyclic moiety selected from (e) aryl, (f) substituted aryl, (g) heteroaryl, or (h) substituted heteroaryl; W is absent, —O—, —S—, —NH—, or —NR 1 —, wherein R 1 is previously defined; Z is (a) hydrogen; (b) —CN; (c) —SCN; (d) —NCO; (e) —NCS; (f) —NHNH 2 ; (g) —N 3 ; (h) halogen; (i) —R 4 , wherein R 4 is (i) —C 1 -C 6 alkyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, (ii) —C 2 -C 6 alkenyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, (iii) —C 2 -C 6 alkynyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; (j) —C 3 -C 12 cycloalkyl; (k) substituted —C 3 -C 12 cycloalkyl; (l) aryl; (m) substituted aryl; (n) heteroaryl; (o) substituted heteroaryl; (p) heterocycloalkyl; and (q) substituted heterocycloalkyl; j=3; m=1; s=1; and R 5 and R 6 are hydrogen.