Patent ID: 7259250

Claim:
A C-nitroso compound having a molecular weight ranging from 225 to 600 on a monomeric basis, wherein a nitroso group is attached to a tertiary carbon atom, wherein a substituent Q is attached to the tertiary carbon atom and consists of a chain moiety containing from 1 to 12 chain atoms consisting of 1 to 10 carbon atoms, 0 to 2 nitrogen atoms, and 0 to 2 oxygen atoms covalently bonded to a cyclic moiety which is monocyclic, bicyclic, tricyclic, tetracyclic or pentacyclic, and contains 5 to 24 ring atoms consisting of 2 to 20 carbon atoms, 0 to 4 nitrogen atoms, 0 to 1 oxygen atoms and 0 to 1 sulfur atoms, and where the tertiary carbon atom is attached to at least one carbonyl group, and which is obtained by nitrosylation of a therapeutic agent without NO donor effect having a carbon acid pKa less than about 25 or a therapeutic agent without NO donor effect modified to have a carbon acid pKa less than about 25, in dimeric form where two moieties of the same chemical composition are joined by nitrogen to nitrogen bonding.