Patent ID: 8501189

Claim:
A synthetic human multitarget polypeptide comprising amino acid sequences of at least one immunogenic epitopic cluster (IEC) of at least four different autoantigens related to insulin-dependent diabetes mellitus (IDDM), said at least four autoantigens related to IDDM being selected from the group consisting of preproinsulin (PPI), 67kDa glutamic acid decarboxylase (Gad67), 65kDa glutamic acid decarboxylase (Gad65), islet cell antigen p69 (ICA69), tyrosine phosphatase islet antigen 2(IA-2), imogen and 60kDa human heat shock protein (Hsp60), wherein one or more cystein residue in a native IEC is optionally substituted by a serine residue, provided that any said Cys→Ser substituted IEC improves the solubility of the native IEC.