Patent ID: 7385066

Claim:
A racemic or homochiral compound of Formula I: or a solvate, hydrate, pharmaceutically acceptable salt, or prodrug thereof; wherein: Z is —CO—, —SO 2 —, —SO 2 CH 2 —, —COCH 2 —, —CONH—, or a direct bond wherein the carbonyl carbon or the sulfur is bonded to the nitrogen; Q is C 1-4 alkyl, halo, amino, C 1-6 alkylthio, C 2-6 alkenylthio, C 1-6 alkoxy, trifluoromethyl, methylsulfonyl, or benzylthio; R 1 is hydrogen, C 1-4 alkyl, or aryl, any of which except hydrogen is optionally substituted with one or two substituents independently selected from: guanidinyl, halogen, —CF 3 , —CN, —NO 2 , —NR d COR e , —CONR d R e , —NR d SO 2 R e , —SO 2 NR d R e , —NR d CONHR e , —R d , —NR d R e , —CO 2 R d , or —SO 2 R d ,; R 2 is hydrogen, halogen, or aryl, wherein the aryl is optionally substituted with up to three substituents independently selected from the group consisting of: C(1-4)alkyl, —NR f R g , and guanidinyl; A is aryl; and R a , R b R c , R d R e , R f and R g are independently hydrogen, C 1-4 alkyl, C 6-10 aryl, C 1-4 hydroxyalkyl, C 1-4 aminoalkyl, mono (C 1-4 )alkylamino(C 2-6 )alkyl, di(C 1-4 ) alkylamino(C 2-6 )alkyl, carboxy(C 1-4 )alkyl, cyano, nitro, amino, C 1-4 alkoxy, hydroxy, or —CO 2 R w , wherein R w is hydrogen, hydroxy, C 1-4 alkoxy, cyano, C 1-4 alkoxycarbonyl, C 1-4 alkyl, C 3-8 cycloalkyl, phenyl, or benzyl.