Patent ID: 7468367

Claim:
A compound of formula (I): wherein: R represents an optionally substituted (C 1-4 )alkyl group; Y represents hydrogen or an optionally substituted (C 1-4 )alkyl group; Het represents an optionally substituted 5- or 6-membered heteroaryl group containing up to 3 heteroatoms selected from N, O, and S, or an optionally substituted bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; Ar represents a phenyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, pyridyl, triazolyl, triazinyl, pyridazinyl, pyrimidinyl, isothiazolyl, isoxazolyl, pyrazinyl pyrazolyl, naphthyl, quinolinyl, napththyridinyl, benzimidazolyl, benzoxazolyl, isoquinolinyl, quinoxalinyl or quinazolinyl group, wherein said group is optionally substituted and is substituted by R 3 ; R 3 independently represents hydrogen, an optionally substituted (C 1-4 )alkoxy group, halo, an optionally substituted (C 1-6 )alkyl group, an optionally substituted phenyl group, or an optionally substituted 5- or 6-membered heterocyclic ring group containing up to 3 heteroatoms selected from N, O and S; wherein the substituents for the optionally substituted R, Y, Het, Ar, and R 3 groups are selected from halogen, hydroxy, oxo, cyano, nitro, (C 1-4 )alkyl, (C 1-4 )alkoxy, halo(C 1-4 )alkyl, halo(C 1-4 )alkoxy, (C 1-4 )acyl, aryl, aryl(C 1-4 )alkyl, aryl(C 1-4 )alkoxy, (C 1-4 )alkylthio, (C 1-4 )alkylamino(C 1-4 )alkyl, hydroxy(C 1-4 )alkyl, hydroxy(C 1-4 )alkoxy, (C 1-4 )alkoxy(C 1-4 )alkyl, (C 3-6 )cycloalkyl(C 1-4 )alkoxy, (C 1-4 )alkanoyl, (C 1-4 )alkoxycarbonyl, (C 1-4 )alkylsulfonyl, (C 1-4 )alkylsulfonyloxy, (C 1-4 )alkylsulfonyl(C 1-4 )alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl(C 1-4 )alkyl, (C 1-4 )alkylsulfonamido, (C 1-4 )alkylamido, (C 1-4 )alkylsulfonamido(C 1-4 )alkyl, (C 1-4 )alkylamido(C 1-4 )alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamido(C 1-4 )alkyl, arylcarboxamido(C 1-4 )alkyl, aroyl, aroyl(C 1-4 )alkyl, aryl(C 1-4 )alkanoyl, R a R b N—, R a R b N(CH 2 )n-, R a R b N(CH 2 )nO—, R a OCO(CH 2 ) r , R a CON(R b )(CH 2 ) r , R a R b NCO(CH 2 ) r , and R a R b NSO 2 (CH 2 ) r . wherein each of R a and R b independently represents a hydrogen atom or a (C 1-4 )alkyl group or where appropriate R a R b forms part of a (C 3-6 )azacycloalkane or a (C 3-6 )(2-oxo)azacycloalkane ring, n represents an integer from 1 to 4, and r represents zero or an integer from 1 to 4, or wherein when the substituent is R a R b N(CH 2 )n- or R a R b N(CH 2 )nO, R a with at least one CH 2 of the (CH 2 )n portion of the group form a (C 3-6 )azacycloalkane and R b represents hydrogen a (C 1-4 )alkyl group or with the nitrogen to which it is attached forms a second (C 3-6 )azacycloalkane; and wherein, in groups Ar and Het, substituents positioned ortho to each other are optionally linked to from a fused ring, or a pharmaceutically acceptable salt thereof, provided the compound is not N-[2-(7-chloro-quinolin-4-ylamino)ethyl]-N-methyl-phthalamic acid; or N-methyl-n-[2-napthalen-2-ylaminoethyl]benzamide.