Patent ID: 8101726

Claim:
An antibody ligand or an antigen-binding fragment thereof that binds to a binary uPA-uPAR complex and to a ternary complex of uPA-uPAR with an additional molecule X, which ligand is further characterized by the following properties: (a) does not substantially bind to (i) free uPA or (ii) the region of uPAR that recognizes and binds to uPA, so that the ligand does not inhibit uPA-uPAR binding (b) does not substantially bind to any of the following: (i) a uPA-X complex, (ii) the uPA-recognizing and uPA-binding region of X, (iii) free uPA, and (iv) free X; and (c) does not substantially inhibit uPA binding with uPAR or with X, and wherein the antibody or fragment comprises the structural properties of (1) or (2), below (1) the antibody or antigen-binding fragment comprises: (A) a V L chain comprising three CDR's which have the respective combination of amino acids sequences (1) SEQ ID NO:3, SEQ ID NO:4 and SEQ ID NO:5; or (2) SEQ ID NO:11, SEQ ID NO:12 and SEQ ID NO:13; and /(B) a V H chain comprising three CDR's which have the respective combination of amino acids sequences (1) SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8, or (2) SEQ ID NO:14, SEQ ID NO:15 and SEQ ID NO:16, or (2) the antibody or antigen-binding fragment comprises: (A) a V L chain that has the sequence SEQ ID NO:1 or SEQ ID NO:9; and (B) a V H chain that has the sequence SEQ ID NO:2 or SEQ ID NO:10.