Patent ID: 8084643

Claim:
A compound having the Formula (I) in which: R is selected from the group consisting of A is oxygen and a is zero or 1; L is (a) CH 2 and l is an integer from 1 to 6; (b) CHR 1 where R 1 is an amino acid side chain and l is 1; or (c) CHR 1 NHC(O)CH(NH 2 )R 2 where R 1 and R 2 are amino acid side chains and l is 1; M is (a) oxygen or sulfur and m is zero or one; (b) CH 2 and m is zero or an integer from 1 to 4; or (c) NH and m is 1; X is (a) CH 2 and x is zero or an integer from 1 to 4; or (b) C(O) and x is 1; and Y is (a) NH 2 ; (b) NHR x where R x is methyl, ethyl, n-propyl or isopropyl; (c) NR y R z where R y and R z are independently hydrogen, methyl, ethyl, n-propyl or isopropyl, or R y and R z taken together form a C 2 -C 5 alkylene chain, or a C 2 -C 4 alkylene chain further including a nitrogen or oxygen heteroatom in said chain; (d) C(═NH)NH 2 ; (e) N + R 4 R 5 R 6 where R 4 , R 5 and R 6 are independently hydrogen, methyl or ethyl, or R 4 and R 5 taken together form a C 2 -C 5 alkylene chain, or a C 2 -C 4 alkylene chain further including a nitrogen or oxygen heteroatom in said chain; (f) pyridinium; (g) N-methyl or N-ethyl pyridinium; (h) N′-3-methyl-N-1-imidazolium; (i) a phenyl group substituted by a group having the formula NR 4 R 5 or N + R 4 R 5 R 6 where R 4 , R 5 and R 6 are as defined above; or (j) NH—CR 3 (═NH) where R 3 is hydrogen, methyl or amino; and R 7 is selected from the group consisting of dichloromethyl, difluoromethyl, trifluoromethyl, cyanomethyl, azidomethyl, and aminomethyl; provided that the group A a L l M m X x Y is other than an alpha-N-unfunctionalized glycine, ornithine or lysine residue; and provided that when a is 0; one or more L, M or X are CH 2 ; and Y is NH 2 ; the sum of l, m, and x is 2-6; and pharmaceutically acceptable salts thereof.