Patent ID: 8383392

Claim:
A transformant of an actinobacterium, originally capable of producing daunorubicin, comprising a ketoreductase gene involved in the biosynthesis of L-epivancosamine, wherein the ketoreductase gene is selected from: a) a gene which encodes a protein comprising the amino acid sequence of SEQ ID NO: 1; b) a gene which encodes a protein comprising an amino acid sequence in which 1-20 amino acids are deleted, substituted, or added in the amino acid sequence of SEQ ID NO: 1 wherein said amino acid sequence has ketoreductase activity; c) a gene which encodes a protein comprising an amino acid sequence having a 95% or more identity with the amino acid sequence of SEQ ID NO: 1 wherein said amino acid sequence has ketoreductase activity; or d) a DNA consisting of the nucleotide sequence of SEQ ID NO: 2.