Patent ID: 8097468

Claim:
A method of predicting an increased risk of relapse following therapy or distinguishing between L1/L2 and L3 in a patient with acute lymphoblastic leukemia (ALL) comprising: (a) performing mass spectrometry on a plasma sample from said patient to generate a protein spectra comprising protein peaks; (b) identifying a protein peak or group of protein peaks in the protein spectra corresponding to one or more of Peak 30 (7727.972 Daltons), Peak 31 (61940.76 Daltons), Peak 32 (124797.7 Daltons), Peak 33 (53623.64 Daltons), Peak 34 (10216.72 Daltons), Peak 35 (145023.4 Daltons), Peak 36 (6808.864 Daltons), Peak 37 (7249.661 Daltons), Peak 38 (6588.005 Daltons), Peak 39 (78971.03 Daltons), Peak 40 (4924.562 Daltons), Peak 41 (55864.83 Daltons), Peak 42 (6801.569 Daltons), Peak 43 (13298.19 Daltons), Peak 44 (83531.42 Daltons), Peak 45 (39542.43 Daltons), Peak 46 (159276.8 Daltons), Peak 47 (106256.1 Daltons), Peak 48 (88687.58 Daltons), Peak 49 (135305.2 Daltons), Peak 50 (7727.865343 Daltons), Peak 51 (10214.09619 Daltons), Peak 52 (9263.336516 Daltons), Peak 53 (10217.12293 Daltons), Peak 54 (7722.657526 Daltons), Peak 55 (7728.041349 Daltons), Peak 56 (9268.979905 Daltons), Peak 57 (7741.020002 Daltons), Peak 58 (9248.709422 Daltons), Peak 59 (7720.190664 Daltons), Peak 60 (13870.3916 Daltons), Peak 61 (7725.474001 Daltons), Peak 62 (9275.311795 Daltons), Peak 63 (41782.2775 Daltons), Peak 64 (8896.712054 Daltons), Peak 65 (4911.78345 Daltons), Peak 66 (83363.03733 Daltons), Peak 67 (45087.95748 Daltons), Peak 68 (121673.475 Daltons), or Peak 69 (7727.155842 Daltons), and (c) predicting risk of relapse following therapy or distinguishing between L1/L2 and L3 based on the identification of one or more of Peaks 30-69, wherein Peaks 30-49 are predictive of an increased risk of relapse following therapy, and Peaks 50-69 distinguish between L1/L2 and L3 ALL.