Patent ID: 7335660

Claim:
A compound of the formula in which R 1 is —CONR 13 R 14 or —(CH 2 ) t —R 21 , where R 13 and R 14 are each hydrogen or C 1-6 alkyl, or R 13 and R 14 taken together with the nitrogen atom to which they are attached form a morpholino, pyrrolidino or piperidinyl ring optionally substituted with one or two C 1-6 alkyl groups; —R 21 is where R 13 , R 14 , R 22 and R 23 are each hydrogen or C 1-6 alkyl, or R 13 and R 14 taken together with the nitrogen atom to which they are attached form a morpholino, pyrrolidino or piperidinyl ring optionally substituted with one or two C 1-6 alkyl groups; R 24 is selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, carboxy, hydroxy, cyano, halo, trifluoromethyl, nitro, amino, C 1-6 acylamino, C 1-6 alkylthio, phenyl or phenoxy; R 2 is hydrogen, C 1-6 alkyl, C 1-6 alkoxy or halo; R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are each hydrogen or C 1-6 alkyl; R 9 , R 10 , R 11 and R 12 are each hydrogen, C 1-6 alkyl or —(CH 2 ) q —OR 20 , wherein R 20 is C 1-6 alkyl; n is 1 or 2; p is 0, 1 or 2; t is 0, 1, or 2; R 25 is hydrogen or C 1-6 alkyl; —X—Y— is where Z is in which -T- is —CH 2 —, —O—, —S—, C(O)— or —CH═CH—, and m and s are each 0 or 1; and R 15 and R 19 are each hydrogen, halo, C 1-6 alkyl or C 1-6 alkoxy, carboxy-C 1-6 alkyl, cyano, halogen, trifluoromethyl, trifluoromethoxy, nitro, amino, C 1 -C 6 acylamino or C 1 -C 6 alkylthio; and provided that when -T- is —CH 2 —, —O—, —S— or —C(O)—, then (m+s) is 1 or 2; or a pharmaceutically acceptable salt thereof.