Patent ID: 6867183

Claim:
A pharmaceutical composition comprising: an insulin drug-oligomer conjugate comprising an insulin polypeptide covalently coupled to an oligomeric moiety, wherein the insulin polypeptide is an insulin analog selected from the group consisting of Gly A21 insulin, human; Gly A21 Gln B3 insulin, human; Ala A21 insulin, human; Ala A21 Gln B3 insulin, human; Gln B3 insulin, human; Gln B30 insulin, human; Gly A21 Glu B30 insulin, human; Gly A21 Gln B3 Glu B30 insulin, human; Gln B3 Glu B30 insulin, human; Asp B28 insulin, human; Lys B28 insulin, human; Leu B28 insulin, human; Val B28 insulin, human; Ala B28 insulin, human; Asp B28 Pro B29 insulin, human; Lys B28 Pro B29 insulin, human; Leu B28 Pro B29 insulin, human; Val B28 Pro B29 insulin, human; and Ala B28 Pro B29 insulin, human; a fatty acid component comprising a fatty acid; and a bile salt component comprising a bile salt; wherein the fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1, wherein the fatty acid component is present in an amount sufficient to lower the precipitation point of the bile salt compared to a precipitation point of the bile salt if the fatty acid component were not present in the pharmaceutical composition, and wherein the bile salt component is present in an amount sufficient to lower the solubility point of the fatty acid compared to a solubility point of the fatty acid if the bile salt were not present in the pharmaceutical composition.