Patent ID: 7238528

Claim:
A method of delivering a nucleic acid of interest to a fibroblast-like or a macrophage-like cell in vitro, said fibroblast-like or a macrophage-like cell being isolated from a synovial cavity, the method comprising: providing a recombinant adenovirus of subgroup C comprising the nucleic acid of interest and having a tissue tropism for fibroblast-like or macrophage-like cells, wherein the capsid of said recombinant adenovirus comprises at least one protein of an adenovirus serotype of subgroup C and at least the tissue tropism determining domain of a fiber protein of a second adenovirus serotype, said second adenovirus serotype being selected from the group consisting of adenovirus serotype 11, 16, 35, and 51; and infecting a fibroblast-like or a macrophage-like cell, said fibroblast-like or a macrophage-like cell being isolated from a synovial cavity, with said recombinant adenovirus.