Patent ID: 8198459

Claim:
A process for the preparation of Rufinamide, of formula (I), comprising the regioselective preparation of a compound of formula (II), in which R is COOR 1 wherein R 1 is hydrogen, an alkali metal, a C 1 -C 8 alkyl, aryl-C 1 -C 8 alkyl, or aryl group; CN, CONH 2 , COCH 3 or CH 2 OR 2 wherein R 2 is hydrogen or a hydroxy-protecting group, by a process comprising the 1,3-dipolar cycloaddition reaction of 2,6-difluorobenzyl azide of formula (III) with a terminal alkyne of formula (IV), wherein R is as defined above, in the presence of a catalyst based on a monovalent copper salt; to obtain a compound of formula (II) which is Rufinamide when in a compound of formula (IV) R is CONH 2 ; or a compound of formula (II) wherein R, being as defined above, is different from CONH 2 , and its subsequent conversion to Rufinamide of formula (I).