Patent ID: 7833974

Claim:
A conjugate consisting of: (a) a polypeptide having the amino acid sequence: [Yn . . . Y 1 ]ZX 1 X 2 X 3 S(p)[W 1 . . . Wm] wherein, m equals 1 or 2; n is an integer from 3 to 7, such that said polypeptide consists of 10 to 13 amino acid residues; S(p) is a phosphorylated serine residue or a phosphorylated threonine residue; Z is any amino acid residue excepting serine residue or threonine residue; and X 1 , X 2 , X 3 , Y 1 -Yn and W 1 -Wm are each independently any amino acid residue; and (b) at least one hydrophobic moiety being attached to said polypeptide, said at least one hydrophobic moiety being selected from the group consisting of a fatty acid and an amino acid residue attached to a fatty acid, the conjugate being capable of inhibiting an activity of glycogen synthase kinase-3 (GSK-3), wherein the hydrophobic moiety provides the conjugate with better (i) membrane permeability and/or (ii) interaction with the hydrophobic patch of the GSK-3.