Patent ID: 8507521

Claim:
A heterocyclic derivative of formula I wherein R 1 is C 1-4 alkyl, C 0-4 alkylC 3-8 cycloalkyl, or C 0-4 alkylZ 1 , said C 1-4 alkyl and C 0-4 alkylC 3-8 cycloalkyl being optionally substituted with one or more substituent independently selected from hydroxy, C 1-4 alkyl, C 1 - 4 alkyloxy, CN and halogen; Z 1 is a 4-7 membered saturated ring containing a heteroatom selected from O, S and SO 2 ; n is 1 or 2; each R 2 and R 3 is independently H or C 1-4 alkyl; Y is O or NR 8 ; R 4 , R 5 , R 6 and R 7 are independently H or C 1-4 alkyl; or when Y is NR 8 , either R 4 and R 5 , or R 6 and R 7 , may together represent oxo; R 8 is C 1-4 alkyl, C 0-4 alkylC 3-8 cycloalkyl, or C 0-4 alkylZ 2 , said C 1-4 alkyl and C 0-4 alkylC 3-8 cycloalkyl being optionally substituted with one or more substituent independently selected from hydroxy, C 1-4 alkyl, C 1 - 4 alkyloxy, oxo, CN and halogen; Z 2 is a 4-7 membered saturated ring containing a heteroatom selected from O, S and SO 2 ; X 1 -X 7 are CR 9 ; or one of X 1 -X 7 may be N; each R 9 is independently selected from H, C 1-4 alkyl, C 1-4 alkyloxy, nitrile and halogen, said C 1-4 alkyl and C 1-4 alkyloxy being optionally substituted with one or more substituent independently selected from hydroxy and halogen; R 10 and R 11 are independently H or C 1-4 alkyl; or, when R 10 is alkyl and X 1 is CR 9 , R 10 and R 9 together with the atoms to which they are bonded may form a fused ring optionally comprising a heteroatomic moiety selected from O, S and SO 2 ; or a pharmaceutically acceptable salt thereof.