Patent ID: 7112603

Claim:
A compound of the formula (I): wherein: R 2 is hydrogen; R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethane-sulfonamido, carbonyl, C-carboxy, O-carboxy, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, amino and —NR 11 R 12 where R 11 and R 12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, acetyl, sulfonyl, and trifluoromethanesulfonyl, or R 11 and R 12 together with the nitrogen atom to which they are attached combine to form a five- or six-membered heteroalicyclic ring provided that at least two of R 3 , R 4 , R 5 and R 6 are hydrogen; or R 3 and R 4 , R 4 and R 5 , or R 5 and R 6 combine to form a six-membered aryl ring, a methylenedioxy or an ethylenedioxy group; R 7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, carbonyl, acetyl, C-amido, C-thioamido, amidino, C-carboxy, O-carboxy, sulfonyl and trihalomethane-sulfonyl; R 8 and R 10 are unsubstituted lower alkyl; R 9 is 2-(dimethylaminoethyl)aminocarbonyl, 2-(diethylaminoethyl)aminocarbonyl, 2-(pyrrolidin-1-ylethyl)aminocarbonyl, or 2-(morpholin-4-ylethyl)aminocarbonyl; R 1′ is hydrogen or alkyl; and R 2′ is hydrogen, alkyl, aralkyl, acyl or —P(O)(OR)(OR′) where R and R′ are independently selected from the group consisting of hydrogen, alkyl, aralkyl or aryl; or a pharmaceutically acceptable salt thereof.