Patent ID: 7601750

Claim:
A compound having the formula in which: R 0 is selected from the group consisting of C 1 -C 3 alkyl, cyclopropyl, halo, OR 5 and S(O) m R 5 in which m is 0, 1 or 2; R 1 and R 2 are independently selected from the group consisting of C 2 -C 8 alkenyl, phenylcyclopropyl, phenylpropenyl, R 6 —X 2 —C(R 8 )(R 8 )—R 7 —; and R 6 —X 2 —N(R 8 )—R 7 —; or R 2 is —(CH 2 ) m′ C 6 H 5 , wherein m′ is 0 or an integer from 1 to 3, or R 2 is C 3 -C 6 cycloalkyl; R 3 and R 4 are independently hydrogen, methyl or ethyl; R 5 is methyl or ethyl; R 6 is selected from the group consisting of hydrogen, C 1 -C 10 alkyl, aryl, W, Y, NH 2 , NHCONR 3 R 4 , NHCOOR 3 and NHSO 2 R 9 ; R 7 is selected from the group consisting of a direct bond, an alkyl group having from 1 to 10 carbon atoms, aryl, —(NH) p (CH 2 CH 2 O) q (NH) p — in which p is 0 or 1 and q is an integer from 1 to 4, and W; R 8 is selected from the group consisting of H, Y, OH, —NHCONR 3 R 4 ; —NHCOOR 3 ; —NHSO 2 R 9 , (CH 2 ) r CO 2 R 3 , and (CH 2 ) r CO 2 NR 3 R 4 in which r is an integer from 1 to 3; R 9 is aryl or C 1 -C 6 alkyl; X 2 is selected from the group consisting of a direct bond, —NH—, —N(CH 3 )—, —NCONR 3 R 4 —, NCOOR 3 —, and NSO 2 R 9 ; W is a saturated carbocyclic group; Y is selected from the group consisting of COOH, COOR 3 , CONR 3 R 4 , CONHSO 2 R 5 , hydroxymethyl, —CH 2 COOH, CH 2 CONR 3 R 4 ; and 5-tetrazolyl; and Z is —CH 2 —, —CH(CH 3 )—, C(CH 3 ) 2 — or —CO—; and pharmaceutically acceptable salts thereof.