Patent ID: 8124778

Claim:
A compound having the following structure: wherein Ar is a phenyl or pyridyl having a carbon as its point of attachment to the oxazole; R 1 is independently selected from the group consisting of hydrogen, —(C 1 -C 6 alkyl), —(C 3 -C 6 alkyl), —CF 3 , —CN, —C(O)C 1 -C 4 alkyl optionally substituted with one, two, or three fluoro substituents, —CO 2 (C 1 -C 4 alkyl), —CO 2 H, —C(O)N(R a )R b , —OH, —O(C 1 -C 6 alkyl), halo, —NO 2 , —NR a R b , —N(R a )C(O)R b , —N(R a )SO 2 R b , —SO 2 N(R a )R b , —SR a , —S(O)R a , and —SO 2 R a ; where R a and R b are each independently selected from the group consisting of —H, —(C 1 -C 6 alkyl), and —(C 3 -C 6 cycloalkyl); and R 2 is independently selected from the group consisting of hydrogen, —(C 1 -C 6 alkyl), —(C 3 -C 6 alkyl), —CF 3 , —CN, —C(O)C 1 -C 4 alkyl optionally substituted with one, two, or three fluoro substituents, —CO 2 (C 1 -C 4 alkyl), —CO 2 H, —C(O)N(R c )R d , —OH, —O(C 1 -C 6 alkyl), -halo, —NO 2 , —NR c R d , —N(R c )C(O)R d , —N(R c )SO 2 R d , —SO 2 N(R c )R d , —SR C , —S(O)R C , —SO 2 R c ; where R c and R d are each independently selected from the group consisting of —H, —(C 1 -C 6 alkyl), and —(C 3 -C 6 cycloalkyl); and Ar 1 is selected from the group consisting of: X is selected from the group of diradicals consisting of —CH 2 —, —O—, —S—, —S(O)—, —S(O) 2 —, —NR 5 —, —CH(OH)—, and —C(O)NH—; and R 3 is selected from the group consisting of —NHBOC, —Cl, —Br, —I, —NH 2 , —NO 2 , —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —S(O) 2 (C 1 -C 6 alkyl), —CF 3 , —COOH, and —CO 2 (C 1 -C 6 alkyl); R 4 is selected from the group consisting of —H, —NHBOC, —Cl, —Br, —I, —NH 2 , —NO 2 , —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —S(O) 2 (C 1 -C 6 alkyl), —CF 3 , —COOH, and —CO 2 (C 1 -C 6 alkyl); and R 5 is selected from the group consisting —H, and —(C 1 -C 6 alkyl); and Z is selected from the group of diradicals consisting of —O—, —S—, and —NR 5 —; and m is an integer between 0 and 6; and n is an integer between 0 and 6; with the following provisos: if m is 0, then n cannot be 0; and if X is —CH 2 —, then Ar 1 cannot be phenyl; or a pharmaceutically acceptable salt thereof.