Patent ID: 8063094

Claim:
A compound having the following formula (I): wherein: R 1 and R 2 are H or C 1-3 alkyl; R 3 is C(O)NR 5 R 6 wherein R 5 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, or C 3-7 cycloalkyl; and R 6 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, hydroxy, C 3-7 cycloalkyl, heterocyclyl, aryl, aryloxy, acyl, heteroaryl, C 3-7 cycloalkyl -C 1-6 alkyl, aryl-C 1-6 alkyl, aryl-C 1-6 haloalkyl, heterocyclyl-C 1-6 alkyl, heteroaryl-C 1-6 alkyl, C 3-7 cycloalkyl-C 2-6 alkenyl, aryl-C 2-6 alkenyl, heterocyclyl-C 2-6 alkenyl, heteroaryl-C 2-6 alkenyl, diC 1 -3 alkylamino(CH 2 ) 2-4 , or C 2-6 alkylthio, wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone; wherein each aryl, heterocycle or heteroaryl may be singly or multiply substituted with R y , wherein R y is chosen from: halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, hydroxy, C 3-7 cycloalkyl, heterocyclyl, aryl optionally substituted with R x , aryloxy, acyl, heteroaryl optionally substituted with R x , C 3-7 cycloalkyl —C 1-6 alkyl, aryl-C 1-6 alkyl, aryl-C 1-6 haloalkyl, aryl-C 1-6 aminoalkyl, heterocyclyl-C 1-6 alkyl, heteroaryl-C 1-6 alkyl, C 3-7 cycloalkyl-C 2-6 alkenyl, aryl-C 2-6 alkenyl, heterocyclyl-C 2-6 alkenyl, heteroaryl-C 2-6 alkenyl, C 2-6 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone, —OCF 3 , amino, C 1 -3 alkylamino, diC 1-3 alkylamino, acylamino, hydroxyethylamino, —CN, —CO 2 C 1-3 alkyl, —CH 2 NH 2 , —C(O)N(R a )(R b ) where R a and R b are independently selected from H, C 1-3 alkyl, —CH 2 C(O)NH 2 , —(CH 2 ) n OH,—(CH 2 ) n NR c R d , where n is 2 or 3 and R c and R d are independently selected from H, C 1-3 alkyl and C(O)CH 3 , or —C(O)NH-N═C-R e , where R e is aryl or heteroaryl optionally substituted with R x , or R a and R b together with the N they are connected to form a pyrrolidine, piperazine, piperidine or morpholine ring optionally substituted with one to three groups selected from —CO 2 C 1-3 alkyl, —C(O)NH 2 , —OH, C 1-3 alkyl, amino, C 1-3 alkylamino and diC 1-3 alkylamino; or R 5 and R 6 are taken together with the nitrogen they are connected to form a heterocyclyl ring; R 4 is selected from H, C 1-6 alkyl, halogen and CF 3 ; R x is selected from: amino, C 1-6 alkyl, C 2-6 alkenyl, amino C 1-6 alkyl, hydroxyC 1-6 alkyl, cyano C 1-6 alkyl , C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, hydroxy, C 3-7 cycloalkyl, heterocyclyl, aryl, aryloxy, acyl, heteroaryl, C 3-7 cycloalkyl-C 1-6 alkyl, aryl -C 1-6 alkyl, aryl-C 1-6 haloalkyl, heterocyclyl-C 1-6 alkyl, heteroaryl-C 1-6 alkyl, C 3-7 cycloalkyl -C 2-6 alkenyl, aryl-C 2 - 6 alkenyl, heterocyclyl-C 2-6 alkenyl, heteroaryl-C 2-6 alkenyl, carbonyl, carbamoyl, ureido, or C 2-6 alkylthio wherein the sulfur atom is oxidized to a sulfoxide or sulfone; and n is 3 .