Patent ID: 7078209

Claim:
A method of inhibiting CAK enzyme from Candida , comprising the step of contacting said CAK with a compound of formula (I): wherein: X is N; ring A, taken together with X, is a pyridinyl ring; Y is ═C; one of Z 1 and Z 3 is selected from —CN, —N 3 , acetenyl or cyclopropyl, and the other of Z 1 and Z 3 is: wherein: n is 0 or 1; W is O or S; V is —NH—; Ar is phenyl or a 5- or 6-membered aromatic heterocyclic ring; wherein Ar has up to 3 substituents selected from halogen, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, (C1–C6)-straight or branched alkyl, (C2–C6)-straight or branched alkenyl, O—(C1–C4)-straight or branched alkyl, O—(C2–C4)-straight or branched alkenyl, O-benzyl, O-phenyl, 1,2-methylenedioxy, amino, carboxyl, N—[(C1–C5)-straight or branched alkyl or (C2–C5)-straight or branched alkenyl]carboxamide, N,N-di-[(C1–C5)-straight or branched alkyl or (C2–C5)-straight or branched alkenyl]carboxamide; Z 2 is N(R 1 ) 2 , wherein each R 1 is independently H, C1–C6 alkyl or C2–C6 alkenyl or alkynyl, wherein a —CH 2 — in said alkyl, alkenyl or alkynyl may be replaced by —C(O)—, —C(O)—O—, —O—C(O)—, —C(O)—NH—, —NH—C(O)—, —O—, or —S—.