Patent ID: 8124634

Claim:
A compound of formula (I), or a salt, single enantiomer, or N-oxide thereof: wherein: A 1 is —COOH, or tetrazolyl, and A 2 is hydrogen, —COOH, tetrazolyl; p is 0 or 1 and A 3 is phenyl or cycloalkyl, either of which is optionally substituted with R 4 and/or R 5 ; q is 0; R 3 is hydrogen, C 1 -C 4 alkyl, cycloalkyl, —CF 3 , or —OR 9 ; R 4 and R 5 independently —R 9 , —CN, —F, —Cl, —Br, —OR 9 , —NR 7 R 8 , —NR 7 COR 6 , —NR 7 SO 2 R 6 , —COR 6 , —SR 9 , —SOR 9 or —SO 2 R 6 ; R 6 is C 1 -C 4 alkyl, cycloalkyl, —CF 3 or —NR 7 R 8 ; R 7 and R 8 are independently hydrogen, C 1 -C 4 alkyl or cycloalkyl; R 9 is hydrogen, C 1 -C 4 alkyl, cycloalkyl, or fully or partially fluorinated C 1 -C 4 alkyl; R 1 is (i) a bond, or (ii) —(CH 2 ) a B 1 (CH 2 ) b — wherein a and b are independently 0, 1, 2 or 3 provided that a+b is not greater than 4; or (iii) —C(R 10 )(R 11 )—*, —C(R 10 )(R 11 )—O—*, —C(R 10 )(R 11 )CH 2 —*, —C(R 10 )(R 11 )CH 2 —O—*, —CH 2 C(R 10 )(R 11 )—*, —CH 2 C(R 10 )(R 11 )—O—*, —CH 2 —O—C(R 10 )(R 11 )—* or —C(R 10 )(R 11 )—O—CH 2 —*, wherein the bond indicated by an asterisk is attached to the pyrazole ring R 2 is a divalent radical of formula -Q 1 -A 4 - A 4 is a monocyclic carbocyclic or monocyclic heterocyclic ring, having 3 to 8 ring atoms, optionally substituted with one or more of —F, —Cl, —Br, —CN, —CF 3 , C 1 -C 4 alkyl, cycloalkyl, —OR 9 , oxo, or —NR 7 R 8 ; Q 1 is —C(R 10 )(R 11 )—, —CH 2 —C(R 10 )(R 11 )—CH 2 —, or in either orientation —C(R 10 )(R 11 )CH 2 —, or —CH 2 —B—C(R 10 )(R 11 )—; and B is —O—, —CH(OH)—, —SO 2 —, —CH 2 —or —NR 7 —; B 1 is —CO—, —O—, —S—, —SO—, —SO 2 —, —CH 2 —, —CHOH—or —NR 7 ; R 10 is hydrogen and R 11 is (C 1 -C 3 )alkyl; or R 10 and R 11 are both (C 1 -C 3 )alkyl; or R 10 and R 11 taken together with the carbon atom to which they are attached form a (C 3 -C 5 )cycloalkyl ring.