Patent ID: 8637650

Claim:
Macromolecular compounds having the structure: (nuc-linker) n -marker wherein: nuc is a nucleotide or nucleoside (nuc-component); linker is a linker component wherein the linker links the nuc component to a marker, and the linker comprises the following parts: a) coupling unit L, which provides linkage between the nuc and one end of a water soluble-polymer, said polymer comprising an average length between 100 and 20,000 atoms, and, b) coupling unit T which provides linkage between the marker and the water soluble polymer, wherein, the marker is a marker component comprising at least one macromolecule of at least 2000 Da, a plurality of low molecular weight marker units or a combination of at least one low molecular weight marker unit with a molecular weight below 2000 Da and at least one macromolecular marker unit with a molecular weight of at least 2000 Da; and (n) is a positive integer between 1 and 100, and wherein, the linker is covalently or non-covalently bound to the nuc and the marker.