Patent ID: 8507511

Claim:
A compound according to the general Formula I wherein R 1 is —XSO 2 NR 5 R 6 or —XSO 2 R 8 ; X is a branched or unbranched C 1-4 alkylene, wherein said C 1-4 alkylene optionally can be bound to R 5 or R 6 to form a 5- or 6-membered heterocycle; R 5 and R 6 independently of each other are selected from the group consisting of hydrogen, C 1-4 alkyl, hydroxy-C 1-4 alkyl, C 3-4 alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-4 -alkyl, C 4-7 -heterocycloalkyl-C 0-4 alkyl, C 4-7 -aryl-C 0-4 alkyl, and C 4-7 -heteroaryl-C 0-4 alkyl; or wherein R 5 and R 6 together with the N-atom to which they are bound form a 5- to 8-membered heterocycloalkyl, wherein said cycloalkyl, heterocycloalkyl, aryl, heteroaryl or alkyl is further optionally substituted by up to 2 radicals selected from the group consisting of halo, hydroxy, aminocarbonyl, C 1-4 alkyl, hydroxy-C 1-4 alkyl, C 1-4 alkyl-O—C 1-4 alkyl, C 1-4 alkyl-O—, and —NR 5 R 6 ; R 8 is C 1-4 alkyl, hydroxy-C 2-4 alkyl, C 3-4 alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-4 alkyl, or C 4-7 -heterocycloalkyl-C 0-4 alkyl; wherein said cycloalkyl, heterocycloalkyl or alkyl is further optionally substituted by up to 2 radicals selected from the group consisting of halo, hydroxy, C 1-4 alkyl, hydroxy-C 1-4 alkyl, C 1-4 alkyl-O—C 1-4 alkyl, C 1-4 alkyl-O, and —NR 5 R 6 ; R 2 is one or two substituents independently selected from halogen and hydrogen; R 3 can be 1 to 3 substituents each independently selected from the group consisting of hydrogen, halo, hydroxy, C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkyl-cycloalkyl, C 1-4 alkyl-heterocycloalkyl, —O-heterocycloalkyl, C 1-4 alkoxy, C 2-4 alkenyloxy, —OCF 3 , C 2-4 alkanoyl, C 1-4 alkylsulfonyl, mono- and di-(C 1 -C 4 alkyl)sulfonamido, aminocarbonyl, mono- and di-(C 1 -C 4 alkyl)aminocarbonyl, aryl-C 1-4 alkoxy, heteroaryl-C 1-4 alkoxy, heterocycloalkyl-C 1-4 -alkoxy, heterocycloalkyl-C 1-4 -alkyl, heteroaryl-C 1-4 -alkyl, C 1-4 alkyloxymethyl, hydroxy-C 1-4 alkyloxymethyl, cyano, —COOH, and C 1 -C 4 alkoxycarbonyl, wherein the above mentioned substituents can be further substituted by radicals selected from the group consisting of C 1-4 -alkyl, hydroxyl-C 0-4 -alkyl, C 1-4 -alkoxy, aminocarbonyl, halo, and NR 5 R 6 ; R 4a and R 4b are the same or different and each is independently hydrogen, C 1-4 alkyl, or —NR′R″, wherein R′ and R″ are each independently hydrogen or C 1-4 alkyl; and the N-oxide derivatives, protected derivatives, and the pharmaceutically acceptable salts of such compounds.