Patent ID: 8062573

Claim:
A method of manufacture of a micro-perforator, comprising: providing a solidifiable material, and forming the solidifiable material, optionally in admixture with a diagnostic or therapeutic agent into a desired micro-perforator shape; wherein the step of forming the solidifiable material includes a step of solidifying the solidifiable material such that the solidified material in the desired micro-perforator shape has a plurality of pores that optionally comprise the diagnostic or therapeutic agent; and optically contacting the solidified material in the desired micro-perforator shape with the diagnostic or therapeutic agent such that the diagnostic or therapeutic agent is at least partially enclosed in the plurality of pores, wherein the solidifiable material shrinks during the step of solidifying the solidifiable material, and wherein shrinking of the solidifiable material is controlled by one of formulation of the solidifiable material and drying the solidifiable material to reduce an apex angle of the micro-perforator.