Patent ID: 7109229

Claim:
A compound of Formula I wherein A and B are independently O or S; R 1 is hydrogen, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, hydroxy, hydroxy(C 1 –C 4 )alkyl, halogen, cyano, halo(C 1 –C 4 )alkyl, (C 1 –C 4 alkyl)-NR 5 R 6 , or (C 1 –C 4 alkyl)-(C 1 –C 4 alkyl ester of an amino acid residue); R 2 is hydrogen, C 1 –C 4 alkyl, hydroxy(C 1 –C 4 )alkyl, (C 1 –C 4 alkyl)-NR 5 R 6 , (C 1 –C 4 alkyl)-C(O)NR 5 R 6 , or (C 1 –C 4 alkyl)-(C 1 –C 4 alkyl ester of an amino acid residue); R 3 and R 3 ′ are independently hydrogen, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, or halogen; R 4 is hydrogen or C 1 –C 4 alkyl; R 5 is independently at each occurrence hydrogen, C 1 –C 4 alkyl, hydroxy(C 1 –C 4 )alkyl, (C 1 –C 4 alkyl)-NR 7 R 8 , C(O)NR 7 R 8 , C(O)—(C 1 –C 4 alkyl), or optionally substituted C 3 –C 8 cycloalkyl; and R 6 is independently at each occurrence hydrogen or C 1 –C 4 alkyl; R 7 and R 8 are independently at each occurrence hydrogen or C 1 –C 4 alkyl; or a pharmaceutically acceptable salt thereof.