Patent ID: 8043622

Claim:
A method of reducing the production of a cytokine or chemokine in a subject with an inflammatory lung disease, comprising administering to the subject with the inflammatory lung disease a suppressive oligodeoxynucleotide, wherein the oligodeoxynucleotide comprises from 2 to 4 guanosine-rich sequences and forms a G-tetrad, wherein the oligodeoxynucleotide comprises the nucleic acid sequence set forth as one of SEQ ID NO: 1, SEQ ID NO: 14, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, or SEQ ID NO: 21, wherein the oligodeoxynucleotide is 10 to 30 nucleotides in length, or a combination of two or more thereof, thereby reducing the production of the cytokine or chemokine in the subject with the inflammatory lung disease, wherein the cytokine or chemokine is tumor necrosis factor (TNF), macrophage inflammatory protein (MIP)-2, interleukin (IL)-6 or keratinocyte-derived chemokine (KC).