Patent ID: 8106088

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: X is NH or N(alkyl); Y and Y′ are each independently CH or CF; Z is C; one of R 1 and R 2 is selected from the group consisting of aryl substituted with 0, 1, 2, 3, 4, or 5 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, dialkylamino, and dialkylaminosulfonyl, heteroaryl substituted with 0, 1, 2, 3, or 4 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, dialkylamino, and dialkylaminosulfonyl, and heterocycle substituted with 0, 1, 2, 3, or 4 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkynyl, amido, arylalkyl, arylalkoxycarbonyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, oxo, thioalkoxy, dialkylamino, and dialkylaminosulfonyl; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halo, cyano, and thioalkoxy; R 3 is selected from the group consisting of hydrogen, methyl, alkoxy, halo, and cyano; R 4 and R 5 are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, and cycloalkylalkyl, or R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the structure (a): R 7 , R 8 , R 9 , and R 10 are each independently selected from the group consisting of hydrogen, halo, hydroxyalkyl, fluoroalkyl, and alkyl; or one of the pair R 7 and R 8 or the pair R 9 and R 10 is taken together to form a C 3 -C 6 ring, wherein 0, 1, or 2 heteroatoms selected from O, N, or S replace a carbon atom in the ring; R 11 and R 12 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro; R 13 and R 14 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, and fluoro; L is —[C(R 15 )(R 16 )] n —; R 15 and R 16 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro; m is 0, 1, 2 or 3; and n is 2 or 3.