Patent ID: 7148218

Claim:
A method of treating ovarian or colon tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of formula I where A is —CH═C(R 1 )CH 2 —, —CH 2 N(R 2 )CH 2 —, —CH 2 N(R 2 )C(O)—, —C(O)N(R 2 )CH 2 —, —CH 2 N(CO 2 R 3 )CH 2 — or —CH 2 N(COR 2 )CH 2 —; B is —CH(R 1 )CH═CHCH═CH 2 , —CH(R 2 )R 1 , —CH(R 1 )CH═CHR 2 , —CH(R 1 )CH═CHC(O)OR 2 , —CH(R 1 )CH═CHC(O)N(R 1 )R 2 , —CH(R 1 )CH 2 OR 2 or Ar; C is H, —C(O)N(R 1 )R 2 , —C(O)NHCH 2 (CH 2 ) n N(CH 3 ) 2 , or —C(O)NHCH 2 (CH 2 ) n -4-morpholino; R 1 is H or (C 1-6 )alkyl; R 2 is H, (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 2-6 )alkynyl, (C 1-6 )alkyl-Ar or Ar; R 3 is (C 1-6 )alkyl, (C 1-6 )alkyl-Ar or Ar; Ar is an aromatic or heteroaromatic ring selected from R 4 and R 5 are, independently, H, (C 1-6 )alkyl, OH, O(C 1-6 )alkyl, OCH 2 (CH 2 ) n OH, O(CH 2 ) n CO 2 H, OCH 2 (CH 2 ) n N(CH 3 ) 2 , OCH 2 (CH 2 ) n -4-morpholino, F, Cl, Br or CF 3 ; and n is 1 or 2; with the proviso that when A is —CH═C(CH 3 )CH 2 — or —CH═CHCH 2 —, then either: B cannot be —CH(CH 3 )CH═CHCH═CH 2 , —CH(CH 3 )CH 2 Ph, —CH(CH 3 )Ph, —CH(CH 3 )-n-Bu, or C cannot be —C(O)N(R 1 )R 2 or H; or an acid or base addition salt thereof, where possible.