Patent ID: 8389546

Claim:
A method for treating a condition involving activation of TRPV3 or for which reduced TRPV3 activity can reduce the severity, comprising administering to a subject in need thereof an effective amount of a compound of Formula I or a salt thereof: wherein: R 1 represents H; R 2 , R 3 and R 4 independently represent H, lower alkyl, alkoxy, carboxyl, ester, amido, sulfonamido, heterocyclyl, cycloalkyl, hydroxyl, amino, acylamino, thioether, sulfonylamino, nitro, halogen, CF 3 , aryl, —CH 2 CH═CF 2 , —CH═CF 2 , or cyano; R 5 is, independently for each occurrence, lower alkyl, alkoxy, carboxyl, ester, amido, sulfonamido, heterocyclyl, cycloalkyl, hydroxyl, amino, acylamino, thioether, sulfonylamino, nitro, halogen, CF 3 , or cyano; X represents S or O; n represents 1 or 2 when X is O, or n represents 1 when X is S; m represents 0, 1, 2, 3, or 4; R 5 represents a substituent on the ring to which it is attached; said compound inhibits TRPV3 with an IC 50 of 10 micromolar or less; and the condition is selected from the group consisting of acute or chronic pain, touch sensitivity, burns, inflammation, diabetic neuropathy, psoriasis, post-herpetic neuralgia (shingles), migraine, incontinence, fever, hot flashes, osteoarthritis, rheumatoid arthritis, and cough.