Patent ID: 8222226

Claim:
A molecule comprising an aptamer linked to a Dicer substrate siRNA, wherein the aptamer is an anti-HIV gp120 aptamer, wherein the Dicer substrate siRNA is a double stranded nucleic acid that targets an HIV-1 target sequence, and wherein the anti-HIV gp120 aptamer is selected from the group consisting of: (a) an anti-HIV gp120 aptamer comprises the nucleotide sequence set forth in SEQ ID NO:12, (b) an anti-HIV gp120 aptamer comprises the nucleotide sequence set forth in SEQ ID NO:8, (c) an anti-HIV gp120 aptamer comprises the nucleotide sequence set forth in SEQ ID NO:9, and (d) an anti-HIV gp120 aptamer of (a), (b) or (c) which is modified to contain 2′-F substituted nucleotides.