Patent ID: 7247725

Claim:
A compound of the formula Ib: wherein the dashed line represents a single or a double bond and wherein R 1 is selected from: and positional and stereo isomers thereof; R 2 is selected from: (C 0-6 alkyl)-phenyl and (C 0-6 alkyl)-heterocycle, where the alkyl is unsubstituted or substituted with 1–7 substituents where the substituents are independently selected from: (a) halo, (b) hydroxy, (c) —O—C 1-3 alkyl, (d) trifluoromethyl, (e) —C 1-3 alkyl, (f) —CO 2 R 9 , and (g) oxo; and where the phenyl and the heterocycle may be unsubstituted or substituted with 1–5 substituents where the substituents are independently selected from: (a) halo, (b) trifluoromethyl (c) trifluoromethoxy, (d) hydroxy, (e) C 1-6 alkyl, (f) C 3-7 cycloalkyl, (g) —O—C 1-6 alkyl, (h) —O—C 3-7 cycloalkyl, (i) —SCF 3 , (j) —S—C 1-6 alkyl, (k) —SO 2 —C 1-6 alkyl, (l) phenyl, (m) hetreocycle, (n) —CO 2 R 9 , (o) —CN, (p) —NR 9 R 10 , (q) —NR 9 —SO 2 —R 10 , (r) —SO 2 —NR 9 R 10 , (s) —ONR 9 R 10 , and (t) —O -phenyl; R 5 is selected from: (a) hydrogen, (b) hydroxy, (c) C 1-6 alkyl, (d) C 1-6 alkyl-hydroxy, (e) —O—C 1-3 alkyl, (f) oxo, and (g) halo, (h) C 0-4 CO 2 R 9 , and (i) CF 3 , R 15 and R 16 are independently selected from: (a) hydrogen, (b) halo, (c) trifluoromethyl, (d) hydroxy, (e) C 1-3 alkyl, (f) —O—C 1-3 alkyl, (g) —CO 2 H, (h) –CO 2 C 1-3 alkyl, (i) —CN, and (j) heterocycle; and pharmaceutically acceptable salts and individual diastereomers thereof.