Patent ID: 8609706

Claim:
A method of treating a bcl-mediated disorder selected from cancer and neoplastic disease, comprising the step of: administering to a patient in need thereof a therapeutically effective amount of a compound of formula 1: or a pharmaceutically acceptable salt thereof; wherein independently for each occurrence m is 0, 1, 2, or 3; n, o, and p are independently for each occurrence 1, 2, 3, 4, or 5; R 1 is —OH, —OC(O)R 6 , —OC(O)N(R 6 )(R 7 ), or —N(R 6 )(R 7 ); R 2 is —OH, —OC(O)Me, —OCH 2 CO 2 H, —OCH 2 CO 2 Et, —N 3 , —N(R 8 )(R 9 ), —N(R)C(O)N(R 8 )(R 9 ), or —N(R)C(O)R 10 ; or has the formula 1b; R 3 is alkyl, halide, alkoxy,(cycloalkyl)alkoxy, aralkyloxy, or —O(CH 2 ) 2 —N(R 15 )(R 16 ); R 4 is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, halide, nitro, amino, acyl, amido, acylamino, aminoalkyl, acylaminoalkyl, acylaminoalkylamino, sulfonylaminoalkylamino, carboxylate, or —N═C(N(R) 2 ) 2 ; R 5 is —OH or —N(R 17 )(R 18 ); R 6 and R 7 are independently for each occurrence H, alkyl, aralkyl, heteroaralkyl, or —[C(R 15 )(R 16 )] n —R 19 ; R 8 and R 9 are independently for each occurrence H, alkyl, aralkyl, or heteroaralkyl; R 10 is alkyl, haloalkyl, or —[C(R 15 )(R 16 )] o —COOR; R, R 11 , R 12 , R 13 , R 14 , R 15 , and R 16 are independently for each occurrence H or alkyl; R 17 and R 18 are independently for each occurrence H, alkyl, aralkyl, heteroaralkyl, alkoxy, or —[C(R 19 )(R 20 )] p —R 21 ; R 19 and R 20 are independently for each occurrence H, hydroxy, alkyl, alkoxy, amino, aminoalkyl, acylamino, sulfonylamino, aryl, aralkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroaralkyl; R 21 is independently for each occurrence H, alkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl, alkoxy, alkylsulfonyl, arylsulfonyl, alkylsulfonamido, arylsulfonamido, amino, amido, or carboxyl; R 22 independently for each occurrence is halide or alkyl; R 23 is selected from the group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, and haloalkyl; R 24 is selected from the group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, and haloalkyl; and R 25 is selected from the group consisting of alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, and haloalkyl.