Patent ID: 7314888

Claim:
A benzene derivative represented by the following formula: wherein R 1 represents a halogen atom, a cyano group, a nitro group, an unprotected or protected hydroxyl group, an unprotected or protected amino group, a mercapto group or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, acyl, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, acylamino, alkylsulfonylamino, arylsulfonylamino or heterocyclic group; R 3 represents a halogen atom, a cyano group, a nitro group, an unprotected or protected carboxyl group, an unprotected or protected hydroxyl group, an unprotected or protected amino group, a mercapto group, a carbamoyl, group or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, acyl, alkoxycarbonyl, aryloxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, acylamino, alkylsulfonylamino, arylsulfonylamino or heterocyclic group; R 4 represents a cyano group, a nitro group, an unprotected or protected carboxyl group, an unprotected or protected hydroxyl group, an unprotected or protected amino group, a mercapto group or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, acyl, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, acylamino, alkylsulfonylamino, arylsulfonylamino or heterocyclic group; X 1 represents —C(O)—, —CH(OH)—, —CH 2 — or a group of the following formula: wherein R 21 represents an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, acyl or heterocycle-lower alkyl group; R 22 and R 23 may be the same or different represent a hydrogen atom or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, acyl, carbamoyl, alkylsulfinyl, alkylsulfonyl, arylsulfonyl or heterocyclic group; and R 24 and R 25 may be the same or different represent a hydrogen atom, a halogen atom, a cyano group, a nitro group, an unprotected or protected carboxyl group, an unprotected or protected hydroxyl group, an unprotected or protected amino group, a mercapto group or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, acyl, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, acylamino, alkylsulfonylamino, arylsulfonylamino or heterocyclic group; the double line of which one line is a broken line denotes a single bond or a double bond; and W represents —Z—COR 26 , —Z—COOR 2 , —O—CH 2 COOR 2 or —O—CH 2 CH 2 COOR 2 , wherein Z represents —(CH 2 ) n — in which n represents 0, 1, 2 or 3 with the proviso that when W is —Z—COOR 2 , n is 2 or 3, —CH 2 CH(CH 3 )—, —CH═CH— or —CH 2 CH═CH—; R 2 represents a hydrogen atom or a protecting group for carboxyl group; and R 26 represents —NHR 27 or —NHSO 2 R 28 in which R 27 and R 28 independently represent an unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl or aralkyl group; or a salt thereof.