Patent ID: 7385050

Claim:
A compound having the structure (I) Phos-Cgp-Trl-Cgp′-Nucl (I) wherein: Phos is a reactive phosphorus group which specifically reacts with a reactive group on a solid support to produce a phosphorous containing linkage group, Trl is a triaryl methyl linker group having three aryl groups, wherein each of the three aryl groups are bound to a central methyl carbon, and at least one of said three aryl groups has one or more substituents, wherein one of said substituents is bound to Cgp and the central methyl carbon is bound to Cgp′, Cgp is a linking group linking the reactive phosphorus group and the triaryl methyl linker group, or is a bond linking the reactive phosphorus group and the triaryl methyl linker group, Nucl is a nucleoside moiety, and Cgp′ is a linking group linking the nucleoside moiety at the 3′O or the 5′O and the triaryl methyl linker group, or is a bond linking the nucleoside moiety at the 3′O or the 5′O and the central methyl carbon of the triaryl methyl linker group; and wherein the reactive phosphorous group has the structure (VI) wherein: the broken line indicates the bond to the Cgp; X is selected from a halo group and a secondary amino group; and Y is selected from hydrido, hydrocarbyl, and substituted hydrocarbyl.