Patent ID: 7994165

Claim:
A method of treating asthma or chronic obstructive pulmonary disease in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (II): wherein: R 1 and R 2 taken together are —NHC(═O)CH═CH— or —CH═CHC(═O)NH—; one of R 5 and R 6 is —[O—C 1-6 alkylenyl] n -NR 10 R 11 or C 1-6 alkylenyl-NR 12 R 13 , and the other of R 5 and R 6 is selected from hydrogen, hydroxy, C 1-4 alkoxy, and C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with halo, wherein each of R 10 , R 11 , R 12 , and R 13 is independently hydrogen or C 1-4 alkyl; or R 10 and R 11 , together with the nitrogen atom to which they are attached, or R 10 , together with the nitrogen atom to which it is attached and a carbon atom of the adjacent C 1-6 alkylenyl, or R 12 and R 13 , together with the nitrogen atom to which they are attached, or R 12 , together with the nitrogen atom to which it is attached and a carbon atom of the adjacent C 1-6 alkylenyl, form a heterocyclic or heteroaryl ring having from 5 to 7 ring atoms and optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, wherein nitrogen is optionally substituted with —S(O) 2 —C 1-4 alkyl; and n is 1 or 2; or a pharmaceutically-acceptable salt or stereoisomer thereof.