Patent ID: 7462612

Claim:
A compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: each R y is independently selected from an optionally substituted C 1-6 aliphatic group, Ar, CN, NO 2 , halogen, N(R) 2 , SR, or OR, provided that two R y groups are not simultaneously Ar; R z is R, C(O)R, C(O)OR, or SO 2 R; Z 1 is C-T (m) R 1 ; T is a valence bond or a C 1-6 alkylidene chain; m is zero or one; R 1 is selected from CN, halogen, OR 3 , SR 3 , N(R)R 3 , or R 4 ; Q is selected from a valence bond, —C(O)N(R)—, —SO 2 N(R)—, —SO 2 —, —N(R)C(O)N(R)—, —N(R)C(O)—, —N(R)SO 2 —, —N(R)SO 2 N(R)—, —N(R)C(O)O—, —C(O)—, or —C(O)O—; R 2 is selected from halogen, CN, (CH 2 ) y R 5 , (CH 2 ) y CH(R 5 ) 2 , (CH 2 ) y CH(R 6 )CH(R 5 ) 2 , (CH 2 ) y N(R 4 ) 2 , or N(R 4 )(CH 2 ) y N(R 4 ) 2 ; each R 3 is independently selected from R or Ar; each y is independently 0-6; each Ar is independently selected from an optionally substituted 3-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or: two R on the same nitrogen atom are taken together with the nitrogen atom attached thereto to form a 4-8 membered saturated, partially unsaturated, or fully unsaturated ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R 4 is independently selected from R 3 , C(O)R 3 , CO 2 R 3 , CON(R 3 ) 2 , SO 2 R 3 ; each R 5 is independently selected from R 3 , OR 3 , C 2 R 3 , (CH 2 ) y N(R 4 ) 2 , N(R 4 ) 2 , N(R)C(O)R 3 , N(R)CON(R 3 ) 2 , CON(R 3 ) 2 , SO 2 R 3 , N(R)SO 2 R 3 , C(O)R 3 , CN, or SO 2 N(R 3 ) 2 ; R 6 is selected from R 3 , (CH 2 ) w OR 3 , (CH 2 ) w N(R 4 ) 2 , or (CH 2 ) w SR 3 ; and each w is independently selected from 0-4.