Patent ID: 8350076

Claim:
A sodium channel blocker represented by the structure: wherein R is selected from the group consisting of C 5 -C 12 alkyl, C 2 -C 9 alkenyl, C 6 -C 9 alkynyl, —(CH 2 ) m COOH, —(CH 2 ) m NH 2 , —(CH 2 ) m CONH 2 , —(CH 2 ) n C 3 -C 6 cycloalkyl, —(CH 2 ) n aryl, and —(CH 2 ) p NCH 3 (CH 2 ) p , wherein m is an integer ranging from 3-8, each n is individually an integer ranging from 0-4 and p is an integer ranging from 1-4; R 2 is selected from the group consisting of —(CH 2 ) n COOH, —(CH 2 ) n NH 2 , and —(CH 2 ) n CONHR 10 ; R 3 is selected from the group consisting of hydroxy, amino, C 1 -C 4 alkoxy, —CH 2 OH and —CONH 2 , wherein R 3 is not hydroxy when R 2 is —(CH 2 ) n CONHR 10 and R 10 is H or when R 2 is —(CH 2 ) n COOH; R 4 and R 5 are independently selected from the group consisting of H, halo, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, and C 1 -C 4 alkoxy; and R 6 is selected from the group consisting of H, C 1 -C 8 alkyl, wherein R 7 and R 8 are independently selected from the group consisting of H, C 1 -C 4 alkyl, C 2 -C 4 alkenyl and C 2 -C 4 alkynyl, and R 9 is H, and R 10 is selected from the group consisting of H, benzyl and C 1 -C 4 alkyl; with the proviso that R 2 , R 3 , R 4 , R 5 and R 6 are not simultaneously as follows: R 2 : —(CH 2 ) n CONHR 10 , wherein n is 3 or 4, R 3 : hydroxyl, R 4 : H 5 R 5 : H, and R 6 : wherein n is an integer ranging from 0-2; with the proviso that R 2 , R 3 , R 4 , R 5 and R 6 are not simultaneously as follows: R 2 : —(CH 2 ) n CONHR 10 , wherein n is 3 or 4, R 3 : hydroxyl, R 4 : C 1 -C 4 alkyl, R 5 : C 1 -C 4 alkyl, and R 6 : wherein n is an integer ranging from 0-2; with the proviso that R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are not simultaneously as follows: R: R 2 : —(CH 2 ) n CONHR 10 , wherein n is 3 or 4, R 3 : hydroxyl, R 4 : H, halo or C 1 -C 4 alkoxy, R 5 : H, halo or C 1 -C 4 alkoxy, and R 6 : H.