Patent ID: 8871944

Claim:
A process for producing a thiazole derivative, comprising: dissolving a secondary N-arylmethyl thioamide or secondary N-pyridylmethyl thioamide in a solvent; adding a strong base to the solution with mixing, while maintaining said solution between −78° C. and ambient temperature, wherein the strong base is selected from the group consisting of n-butyllithium, lithium, diisopropylamide, sodium hydride, potassium hydride, potassium t-butoxide, calcium hydride, sodium hydroxide, and sodium amide; adding a thioformamide selected from the group consisting of N,N-dimethylthioformamide, N-morpholinothioformamide, and N,N-diphenylthioformamide to form the thiazole derivative; and adding a thioformamide to form the thiazole derivative.