Patent ID: 8846909

Claim:
A compound of structural Formula VI or a salt thereof, wherein: Y 3 is chosen from a bond, lower alkyl, lower carboxyl, and lower heteroalkyl; Y 4 is chosen from O, S, C(O), SO, SO 2 , NH, N(CH 3 ), CH 2 , CHF, CF 2 , CH(CH 3 ), C(CH 3 ) 2 , CH 2 O—, and —CH 2 N—; and R 2 is chosen from phenyl and 6-membered monocyclic heteroaryl, either of which is optionally substituted with one or more substituents chosen from deuterium, halogen, hydroxy, lower amino, lower amido, C 1 -C 3 alkoxy, and C 1 -C 3 alkyl; R 3 is chosen from cycloalkyl, aryl, heteroaryl, bicyclic heteroaryl, any of which is optionally substituted with one or more substituents chosen from deuterium, halogen, hydroxy, lower amino, lower amido, lower carboxyl, C 1 -C 3 alkoxy, C 1 -C 3 alkyl, (O), (S), cyano, haloalkyl, phenyl, cycloalkyl, heteroaryl, and cycloheteroalkyl; R 14 is chosen from lower heteroalkyl, lower heterocycloalkyl, and lower heteroaryl, any of which is optionally substituted with one or more substituents chosen from deuterium, halogen, hydroxy, lower amino, lower amido, lower carboxyl, C 1 -C 3 alkoxy, C 1 -C 3 alkyl, (O), (S), haloalkyl, phenyl, benzyl, and lower cycloalkyl.