Patent ID: 8829004

Claim:
A method for the treatment of cancer comprising the step of administering to a subject in need thereof an effective amount of a medicament comprising a combination of a nitric oxide dioxygenase inhibitor selected from the group consisting of itraconazole, fluconazole, econazole, bifonazole, ketoconazole, sulconazole, miconazole, hydraconazole, exonazole and zylconazole and an arginase inhibitor selected from the group consisting of (S)-(2-boronoethyl)-L-cysteine (BEC), 2(S)-amino-6-boronohexanoic acid (ABHA), N G -hydroxy-L-arginine (L-NOHA), N omega -hydroxy-nor-L-arginine (nor-NOHA), and DL-alfa-difluoromethylornithine (DFMO), wherein the nitric oxide dioxygenase inhibitor reduces the enzyme activity for catalyzing the formation of nitrate from nitric oxide, and wherein the arginase inhibitor reduces the enzyme activity for catalyzing the formation of citrulline from arginine.