Patent ID: 8404637

Claim:
A gastric inhibitory peptide (GIP) hybrid polypeptide exhibiting at least two hormonal activities, said hybrid polypeptide comprising a first bio-active peptide hormone covalently linked to at least one additional bio-active peptide hormone; wherein: the first bio-active peptide hormone is a GIP, a bio-active fragment of the GIP of at least 21 amino acids that exhibits at least one hormonal activity of the GIP, a bio-active analog of the GIP that exhibits at least one hormonal activity of the GIP or a bio-active derivative with a water soluble polymer thereof that exhibits at least one hormonal activity of the GIP, GIP analog or GIP fragment; the at least one additional bio-active peptide is an amylin, a bio-active fragment of the amylin that exhibits at least one hormonal activity of the amylin, a bio-active analog of the amylin that exhibits at least one hormonal activity of the amylin or a bio-active derivative with a water soluble polymer thereof that exhibits at least one hormonal activity of the amylin, amylin analog or amylin fragment; and each of the bio-active peptide hormones exhibits at least one hormonal activity of its parent peptide hormone.