Patent ID: 7375129

Claim:
A compound having a structure of Formula I, and pharmaceutically acceptable salts and pro-drug esters thereof: wherein each of R 1 , R 2 , and R 5 is separately selected from the group consisting of hydrogen atom, mono-substituted C 1 -C 24 alkyl, poly-substituted C 1 -C 24 alkyl and unsubstituted C 1 -C 24 alkyl, wherein at least one of five R 3 is a halogen and at least one of five R 4 is a halogen, and wherein each of the remaining R 3 and R 4 is separately selected from the group consisting of hydrogen atom, halogen atom, mono-substituted, poly-substituted or unsubstituted variants of the following residues: saturated C 1 -C 24 alkyl, unsaturated C 2 -C 24 alkenyl or C 2 -C 24 alkynyl, acyl, acyloxy, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, amino, aminocarbonyl, aminocarboyloxy, nitro, azido, phenyl, hydroxy, alkylthio, arylthio, oxysulfonyl, carboxy, cyano, halogenated alkyl including polyhalogenated alkyl, and some combination thereof; wherein each of R 6 represents substituent(s) on a pyrrole ring at a 2- or a 5-position(s), and each of the two R 6 is separately selected from the group consisting of hydrogen atom, halogen atom, mono-substituted, poly-substituted or unsubstituted variants of the following residues: saturated C 1 -C 24 alkyl, unsaturated C 2 -C 24 alkenyl or C 2 -C 24 alkynyl, acyl, acyloxy, amide (—CO—NR 8 R 9 ), ester, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, amino, aminocarbonyl, aminocarboyloxy, nitro, azido, phenyl, hydroxy, alkoxycarbonyl, aryloxycarbonyl, CO—O—R 7 , carbonyl —CCO—R 7 , —(CH 2 ) n —COOR 7 , —CO—(CH 2 ) n —COOR 7 , alkylthio, arylthio, oxysulfonyl, carboxy, cyano, halogenated alkyl including polyhalogenated alkyl, and some combination thereof with the proviso that R 6 at the 5-position and R 6 at the 2-position are not identical, with the further proviso that if there is 1) an alkyl group at R 5 and if 2) R 6 at the 2-position and the 5-position is either hydrogen or oxygen, then R3 and R4 are asymmetrical.