Patent ID: 8785124

Claim:
A method of treating a biological specimen on an analytic substrate, comprising: disposing a liquid mixture upon an analytic substrate having a biological specimen disposed thereon and a residual wash buffer with at least one detergent present in the buffer disposed over the biological specimen, the liquid mixture comprising an oil-based carrier solution having dispersed therein a quantity of at least one of a plurality of microcapsules and a plurality of nanocapsules encapsulating at least one of a DNA probe and a RNA probe disposed in at least one detergent containing an aqueous solution; and exposing the analytic substrate and the liquid mixture thereon to a temperature change sufficient to cause the release of the at least one of DNA probe and RNA probe and the detergent containing aqueous solution into the oil-based carrier solution such that at least one of the DNA probe and the RNA probe and the detergent containing aqueous solution separate from the oil-based carrier solution so as to become available to act on or react with the biological specimen and the residual wash buffer.