Patent ID: 6861072

Claim:
A controlled-release pharmaceutical composition with gastric residence comprising two or three layers and consisting essentially of: (a) an active principle combined with an excipient which modifies its release, (b) a carbon dioxide-generating system in a swelling hydrophilic polymer matrix consisting of a hydrophilic polymer chosen from the following families of hydrophilic polymers: natural polysaccharides, cellulose derivatives, polyvinylpyrrolidones, polymers derived from acrylic acid and methacrylic acid and salts thereof, or aminoacid polymers, or a mixture of 2 or 3 hyrdophilic polymers chosen from the same family wherein (a) and (b) are included in the same layer [(a)+(b)] or in separate layers ](a)[ and [(b)] and wherein multiple layers containing (a), (b) or (a) and (b) in the same tablet have the same or different compositions and dimensions, and (c) a hydrophilic excipient capable of promoting the hydration of swelling polymer matrices, chosen from lactose, mannitol, sorbitol, microcrystalline cellulose, sodium lauryl sulfate, sodium ricinoleate, sodium tetradecyl sulfate, sodium dioctyl sulfosulfonate, ketomagrocol, poloxamer and polysorbates.