Patent ID: 7960578

Claim:
A method for synthesizing a compound of the following formula (I) wherein: n is an integer larger than or equal to 1; Rb and each Rn represent independently of each other a hydrogen atom, an aryl (C 1 -C 6 alkyl) group, or a C 1 -C 6 alkyl group either substituted or not by an aryl group, —COOH, —COO—(C 1 -C 6 alkyl), —CONH 2 , —SH, heteroaryl, —NH 2 , —NHC(NH)(NH 2 ), —S—(C 1 -C 6 alkyl), —OH or phenol; Ra represents an N-protective group; Rc represents an —ORd group wherein Rd represents a C 1 -C 6 alkyl group or an —NReRf group wherein Re and Rf represent independently of each other an N-protective group, wherein it comprises a step (a) consisting of milling in the presence of a base and without any solvent, the compound of the following formula (II): wherein Ra and Rb are as defined earlier, with the compound of the following formula (III): wherein n, Rn and Rc are as defined earlier, as well as its pharmaceutically acceptable salts.