Patent ID: 8916701

Claim:
A method of making a compound of formula (I): comprising allowing a compound of formula (II): to react in the presence of base to form the compound of formula (I), wherein: m and n are each independently 0, 1 or 2; R 1 is a leaving group selected from chloro, bromo, iodo, methoxy, arylsulfonyloxy and trifluoromethanesulfonyloxy; or R 1 is a carbocyclic or heterocyclic ring selected from phenyl, thienyl, pyridyl, N-oxo-pyridyl, cyclopropyl, piperidinyl, piperazinyl, morpholinyl, thiazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, S,S-dioxothiazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzimidazolyl, benztriazolyl, oxodihydropyridyl, oxodihydropyridazinyl, oxodihydropyrimidinyl and oxodihydropyrazinyl; wherein each of the foregoing R 1 carbocyclic or heterocyclic rings may be optionally substituted by 1 to 4 groups; wherein substituents for ring carbon atoms of said carbocyclic or heterocyclic rings are independently selected from halogen, cyano, oxo, nitro, —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl; and wherein substituents for ring nitrogen atoms of said heterocyclic rings, when present, are selected from —(C 1 -C 6 )alkyl and —(C 3 -C 6 )cycloalkyl; each R 2 and R 3 is independently selected from —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl; wherein each of the —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl of said R 2 and R 3 is optionally independently substituted with one to three R 6 groups; R 4 is selected from —(C 1 -C 6 )alkyl and —(C 3 -C 6 )cycloalkyl; wherein the —(C 1 -C 6 )alkyl and —(C 3 -C 6 )cycloalkyl of said R 4 is optionally substituted with one to three R 6 groups; R 5 is selected from —(C 1 -C 6 )alkyl, —(C 3 -C 6 )cycloalkyl, and phenyl; and each R 6 is independently selected from halo, —(C 1 -C 6 )alkyl, —O(C 1 -C 6 )alkyl, and —(C 3 -C 6 )cycloalkyl.