Patent ID: 7381423

Claim:
A method of preparing a cosmetic formulation of a lipophilic cosmetic active agent in the form of an-oil-in-water nanodispersion, which comprises (α) preparing a nanodispersion prephase by mixing (a) 0.1 to 30% by weight of a phospholipid, (b) 1 to 50% by weight of a polyoxyethylene coemulsifier selected from the group consisting of polyethoxylated fatty alcohols, polyethoxylated fatty acids, polyethoxylated vitamin E derivatives, polyethoxylated lanoline and lanoline derivatives, and polyethoxylated fatty acid glycerides, (c) a lipophilic component comprising a natural or synthetic or a partially synthetic C 4 -C 18 triglyceride, and (d) 3 to 30% by weight of ethanol, until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to a water phase, where component (c) used in step (α), or the water phase in step (β), or both, additionally contain a lipophilic cosmetically active agent, where the total weight of lipophilic cosmetically active agent and C 4 -C 18 triglyceride of component (c) ranges from 20 to 70% by weight, and where the percentages relate to sum of the weight of the components (a), (b), (c), (d) and the lipophilic cosmetically active agent, wherein step (β) is carried out in the absence of high shear or cavitation forces.