Patent ID: 7094790

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein: X is O, S, NH, or N(alkyl); Y, and Y′ are each independently selected from the group consisting of CH, CF, and N; Z is C or N, provided that when X is O or S, Z is N; one of R 1 and R 2 is selected from the group consisting of heteroaryl, and heterocycle; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, and alkoxy; R 3 is absent when Z is N and, when present, R 3 is selected from the group consisting of hydrogen, methyl, alkoxy, halo, and cyano; R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the structure (a): R 7 , R 8 , R 9 , and R 10 are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl; R 11 , and R 12 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro; R 13 and R 14 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, and fluoro; L is —[C(R 15 )(R 16 )] n —; R 15 and R 16 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro; m is 1; and n is an integer from 2–3.