Patent ID: 7202040

Claim:
A method for screening compounds which change binding properties of (i) a protein, its partial peptide, or a salt of the protein or the partial peptide with (ii) a ligand which binds specifically to the protein, its partial peptide, or a salt of the protein or the partial peptide, said method comprising: (A) contacting (i) the protein, its partial peptide, or a salt of the protein or the partial peptide with (ii) the ligand; (B) contacting (i) the protein, its partial peptide, or a salt of the protein or the partial peptide with (ii) the ligand in the presence of a test compound; (C) detecting an activity or a binding amount of (i) the protein, its partial peptide, or a salt of the protein or the partial peptide with (ii) the ligand in the instance of (A) and (B); and (D) comparing the results to identify compounds which change the binding properties of (i) the protein, its partial peptide, or a salt of the protein or the partial peptide with (ii) the ligand, wherein said protein comprises the same or substantially the same amino acid sequence as an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, and said ligand is a compound represented by the formula below: wherein R 1 represents a hydrogen atom, alkyl, alkenyl, alkynyl, cycloalkyl, or acyl, wherein each alkyl, alkenyl, alkynyl, or cycloalkyl may optionally have a substituent; m represents 0 or 1; and R 2 represents a hydrogen atom, alkyl, alkenyl, alkynyl, cycloalkyl, or acyl, wherein each alkyl, alkenyl, alkynyl, or cycloalkyl may optionally have a substituent, or a group represented by the formula below: wherein R 6 represents a hydrogen atom, alkyl which may optionally have a substituent, or cycloalkyl which may optionally have a substituent, and m is 0 or 1; or a salt thereof.