Patent ID: 8710048

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein X is O or S; R 1 is LR 1a wherein L is a covalent bond, alkylidene, or substituted alkylidene, and R 1a is selected from tetrahydropyran-2-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and cyclohexenyl, and each R 1a is unsubstituted or substituted; R 2 is hydrogen or methyl; R 3 is —C(O)NH-L 2 R 3a , wherein L 2 is a covalent bond, alkylidene, or substituted alkylidene, and R 3a is selected from the group consisting of alkyl, haloalkyl, amino, acylamino, (carboxyl ester)amino, hydroxy, alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl, or R 3 is selected from the group consisting of pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyridine-2-yl, pyridine-3-yl, pyridine-4-yl, pyrimidin-4-yl, pyrimidin-3-yl, pyrimidin-2-yl, thiazoyl, tetrazolyl, imidazol-1-yl, imidazol-2-yl, imidazol-3-yl, pyrazinyl, furanyl, oxazole, and oxadiazole, wherein each R 3 is substituted or unsubstituted; each R 6 is independently alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, or halo; n is 0, 1, or 2; and R 4 is hydrogen, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and R 5 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aminocarbonyl, halo, heteroaryl, substituted heteroaryl, cycloalkyl, or substituted cycloalkyl.