Patent ID: 8440193

Claim:
A method for inhibiting bone resorption in a human, the method comprising administering to the human an amount from about 1 mg/kg to about 8 mg/kg of a monoclonal anti-sclerostin antibody or fragment thereof that demonstrates a binding affinity for sclerostin of SEQ ID NO: 1 of less than or equal to 1×10 −9 M, wherein the monoclonal anti-sclerostin antibody or fragment thereof cross-blocks the binding of an antibody comprising heavy chains comprising SEQ ID NOs: 245-247 and light chains comprising SEQ ID NOs: 78-80 to sclerostin and/or is cross-blocked from binding to sclerostin by an antibody comprising heavy chains comprising SEQ ID NOs: 245-247 and light chains comprising SEQ ID NOs: 78-80, wherein bone resorption is inhibited.