Patent ID: 8088931

Claim:
A method of preparing a compound of Formula X, comprising: a) condensing a compound of Formula 1 with a compound of Formula 2, to form a compound of Formula 3; b) condensing the compound of Formula 3 with a compound of Formula 4 and a compound of Formula 5 to form a compound, and reacting that compound with an amine having Formula HNR 10 R 11 , to give a compound of Formula 6; and c) treating the compound of Formula 6 with an oxidizing agent to form a compound of Formula X; wherein: R 1 is optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclic, CO 2 R′, OCOR′, CONR′R″, NR″COR′, NR′SO 2 R″, SO 2 NR′R″, (C═NR′)NR″R′″, or NR′R″; R 5 is H or optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclic, CO 2 R′, OCOR′, CONR′R″, NR″COR′, NR′SO 2 R″, SO 2 NR′R″, (C═NR′)NR″R′″, or NR′R″; R 7 is H; R 9 is one to four groups independently selected from H, F, Cl, Br, I, OH, NO 2 , alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclic, OR′, CO 2 R′, OCOR′, CONR′R″, NR″COR′, NR′SO 2 R″, SO 2 NR′R″, (C═NR′)NR″R′″, or NR′R″; R 10 and R 11 are independently H, OH or optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclic, (CH 2 ) n —R′, (CH 2 ) n —NR′R″, (CH 2 ) n —NR′COR″, (CH 2 ) n —NR′SO 2 R″, (CH 2 ) n —NR′(C═NR″)NR′″, (CH 2 ) n —COOH, (CH 2 ) n —COOR′, (CH 2 ) n —CONR′R″, (CH 2 ) n —OR′, (CH 2 ) n —SR′, (CH 2 ) n —COR′, (CH 2 ) n —SO 3 H, (CH 2 ) n —SONR′R″, (CH 2 ) n —SO 2 NR′R″, (CH 2 CH 2 O) n —(CH 2 ) m —OH, (CH 2 CH 2 O) n —(CH 2 ) m —OR′, (CH 2 CH 2 O) n —(CH 2 ) m —COOR′, (CH 2 CH 2 O) n —(CH 2 ) m —CONR′R″, (CH 2 CH 2 O) n —(CH 2 ) m —NR′R″, (CH 2 CH 2 O) n —(CH 2 ) m —NR′COR″, (CH 2 CH 2 O) n —(CH 2 ) m —NR′(C═NR″)NR′″, (CH 2 CH 2 O) n —(CH 2 ) m —NR′SO 2 R″, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —OH, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —OR′, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —COOR′, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —CONR′R″, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —NR′R″, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —NR′COR″, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —NR′(C═NR″)NR′″, (CH 2 ) p —(CH 2 CH 2 O) n —(CH 2 ) m —NR′SO 2 R″, —CO—R′, —SOR′, or —SO 2 R′; n, m, and p are each independently 1-6; and each R′, R″ and R′″ is independently H or optionally substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heterocyclic; or R′ and R″, or R″ and R′″, form a ring.