Patent ID: 7704740

Claim:
A nanofibrillar structure for the proliferation and/or differentiation of cells in cell culture comprising one or more synthetic polymeric nanofibers and a non-cytotoxic substrate, wherein the nanofibrillar structure is defined by a network of one or more nanofibers, the network having a thickness of a single nanofiber to about 2000 nanometers, wherein the nanofibrillar structure is deposited on a surface of the substrate and comprises one or more nanofibers having a diameter of about 50 to about 1000 nanometers, an average interfiber spacing of about 0.01 microns to about 25 microns, and a solidity of 30 percent to 70 percent; and wherein the nanofibrillar structure promotes the proliferation and/or differentiation of cells cultured on said nanofibrillar structure.