Patent ID: 7629377

Claim:
A method for the treatment of Alzheimer's disease in a mammal, comprising administering to a mammal in need thereof a pharmaceutically effective amount of a compound of Formula 1: wherein: R 1 , R 2 , R 3 , and R 4 are each, independently, hydrogen, alkyl of 1-3 carbons, cycloalkyl of 3-5 carbon atoms, —CH 2 -cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-3 carbons, halogen, hydroxy, aryl optionally substituted with from 1 to 3 groups selected from R 8 , perfluoroalkyl of 1-3 carbons, alkoxy of 1-3 carbons, amino, alkylamino of 1-3 carbons, dialkylamino of 1-3 carbons, perfluoroalkoxy of 1-3 carbons; R 5 is hydrogen, alkyl of 1-6 carbons, perfluoroalkyl of 1-6 carbons, aryl substituted with R 8 , alkanoyl of 1-6 carbons, aroyl optionally substituted with from 1 to 3 groups selected from R 8 ; R 6 is hydrogen, alkyl of 1-6 carbons, alkylaryl, benzyl substituted with R 8 , alkanoyl of 1-6 carbons, aroyl optionally substituted with from 1 to 3 groups selected from R 8 ; R 7 is hydrogen, alkyl of 1-6 carbons, alkylaryl, aryl optionally substituted with from 1 to 3 groups selected from R 8 ; n is an integer of 0-6; A is COOH, or an acid mimic selected from tetrazole, SO 3 H, PO 3 H 2 and tetronic acid; R 8 is hydrogen, alkyl of 1-3 carbons, cycloalkyl of 3-5 carbons, —CH 2 -cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-3 carbons, halogen, hydroxy, perfluoroalkyl of 1-3 carbons, alkoxy of 1-3 carbons, amino, alkylamino of 1-3 carbons, dialkylamino of 1-3 carbons, perfluoroalkoxy of 1-3 carbons; or a pharmaceutically acceptable salt or ester form thereof.