Patent ID: 7368457

Claim:
A compound, or pharmaceutically acceptable salts and/or solvates of said compound, said compound having the general structure shown in Formula I: wherein: Ar is aryl or heteroaryl; X is O, NH, or NR 6; m is 1 and a double bond may or may not be present or a triple bond may or may not be present; n is 2; R 1 is 1 to 3 substituents independently selected from the group consisting of: hydrogen, alkyl, cycloalkyl, halogen, —CF 3 , —OCF 3 , —NR 6 R 7 , —CN, —NO 2 , -NH 2 , -alkylene-NR 6 R 7 , -alkylene-O-alkyl, —C(O)O-alkyl, —C(O)NR 6 R 7 , —N(R 6 )C(O)alkyl, —N(R 6 )C(O)cycloalkyl, —N(R 6 )C(O)aryl, —N(R 6 )C(O)heteroaryl, —N(R 6 )C(O)O-alkyl, —N(R 6 )C(O)NR 6 R 7 , —N(R 6 )S(O) 2 alkyl, —OH, —O-alkyl, and —O-cycloalkyl; R 2 is hydrogen, -alkyl, -cycloalkyl, -alkylene-cycloalkyl, -cycloalkyl, —NR 6 R 7 , -alkylene-NR 6 R 7 , -alkylene-O-alkyl, —O-alkyl, -heteroaryl, or -aryl; R 3 is 1 to 6 substituents, which can be the same or different, each being independently selected from hydrogen, halogen, -alkyl, -cycloalkyl, —OH, —OCF3, —CF3, —O-alkyl, —O-cycloalkyl, or —NR 6 R 7 ; R 4 is hydrogen, -alkyl, -cycloalkyl, -aryl or -heteroaryl; or R 3 and R 4 can be joined together to form a 3 to 6 member ring; R 5 is —NR 6 R 7 , —N(R 6 )-alkylene-NR 6 R 7 , -alkyl, -cycloalkyl, -aryl, -heteroaryl, -cycloalkyl, -alkylene-aryl, -alkylene-heteroaryl, -cycloalkylene-aryl, -cycloalkylene-heteroaryl, -heterocycloalkyl-aryl or -heterocycloalkyl-heteroaryl; or R 5 is selected from the group consisting of: R 6 and R 7 can be the same or different, each being independently selected from the group consisting of: hydrogen, -aryl, heteroaryl, -alkyl, -cycloalkyl, -alkylene-aryl, -alkylene-heteroaryl, r is 0, 1, 2, 3 or 4; s is 0, 1, 2 or 3; R 8 is hydrogen, —OH, alkyl, —C(O)NR 6 R 7 , —C(O)O-alkyl, or aryl, wherein said alkyl moiety may be unsubstituted or substituted with 1 to 4 hydroxy groups, and said aryl group may be unsubstituted or substituted with at least one substituent selected from the group consisting of alkyl, cycloalkyl, halogen, —CF 3 , —OCF 3 , —NR 6 R 7 , —CN, —NO 2 , —NH 2 , -alkylene-NR 6 R 7 , -alkylene-O-alkyl, —C(O)O-alkyl, —C(O)NR 6 R 7 , —N(R 6 )C(O)alkyl, —N(R 6 )C(O)cycloalkyl, —N(R 6 )C(O)aryl, —N(R 6 )C(O)heteroaryl, —N(R 6 )C(O)O-alkyl, —N(R 6 )C(O)NR 6 R 7 , —N(R 6 )S(O) 2 alkyl, —OH, —O-alkyl, and —O-cycloalkyl; R 9 is selected from the group consisting of: hydrogen, alkyl, -cycloalkyl, -alkylene-aryl, -alkylene-heteroaryl, -alkyl-cycloalkyl, —C(O)O-alkyl, -alkylene-O-alkylene-OH, -aryl and -heteroaryl, wherein each said alkyl and cycloalkyl moieties may be independently substituted or unsubstituted, and if substituted then substituted with 1 to 4 hydroxy groups or at least one —NR 6 R 7 group; each R 10 is independently selected from hydrogen or alkyl wherein said alkyl group may be substituted or unsubstituted and if substituted then R 10 is substituted with 1 to 4 hydroxy groups; each R 11 and R 12 are each independently selected from hydrogen, alkyl, or aryl; p is 0, 1, 2, 3 or 4; and q is 0, 1 or 2.