Patent ID: 7928106

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: X 1 is N; X 2 is C(R 7 ); and X 3 is C(R 8 ); and wherein R7 and R8 independently from each other are selected from the group consisting of: (1) hydrogen, (2) halogen, (3) lower-alkyl, (4) fluoro-lower-alkyl, (5) lower-alkoxy, (6) fluoro-lower-alkoxy, and (7) cycloalkyl; Y is selected from the group consisting of: (1) a single bond, (2) O, (3) N(R 9 )C(O), (4) C(O)NR 9 , (5) N(R 9 )C(O)O, (6) OC(O)NR 9 , (7) N(R 9 )C(O)NR 10 , (8) N(R 9 )SO 2 , and (9) SO 2 N(R 9 ); wherein R 9 and R 10 independently from each other are selected from the group consisting of hydrogen, lower-alkyl and fluoro-lower-alkyl; Z is a single bond, or, if n is 1, 2, 3, 4, 5 or 6, Z can also be O; R 1 , R 2 , R 3 and R 4 independently from each other are selected from the group consisting of: (1) hydrogen, (2) fluoro, (3) lower-alkyl, and (4) fluoro-lower-alkyl; or R 1 and R 2 are bound together with the carbon atom to which they are attached to form a ring of 3 to 7 carbon atoms; or R 3 and R 4 are bound together with the carbon atom to which they are attached to form a ring of 3 to 7 carbon atoms; R 5 is aryl or heteroaryl, which aryl or heteroaryl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of: (1) halogen, (2) lower-alkyl, (3) lower-alkoxy, (4) fluoro-lower-alkyl, (5) fluoro-lower-alkoxy, (6) cycloalkyl, (7) fluoro-cycloalkyl, (8) cycloalkyl-oxy, (9) C(O)OH, (10) lower-alkoxy-C(O), (11) NH 2 C(O), (12) N(H,lower-alkyl)C(O), (13) N(lower-alkyl) 2 C(O), (14) OH, (15) lower-alkyl-C(O)O, (16) NH 2 , (17) N(H,lower-alkyl), (18) N(lower-alkyl) 2 , (19) lower-alkyl-C(O)NH, (20) lower-alkyl-C(O)N(lower-alkyl), (21) NH 2 SO 2 , (22) N(H,lower-alkyl)SO 2 , (23) N(lower-alkyl) 2 SO 2 , (24) lower-alkyl-SO 2 —NH, (25) lower-alkyl-SO 2 —N(lower-alkyl), (26) cyano, and (27) phenyl which is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy and fluoro-lower-alkyl; m is 0, 1, 2 or 3; and n is 0, 1, 2, 3, 4, 5 or 6; wherein m+n is ≧1.