Patent ID: 8354406

Claim:
A compound according to formula (I): wherein: R1 is the group -XYZ; X is 2- or 3-thiophenyl; Y is a bond or C 1 -C 4 alkylene; Z is —NR4R5 or heterocycloalkyl, where said heterocycloalkyl is optionally substituted with one or two substituents each independently selected from the following: 1) C 1 -C 6 -alkyl optionally substituted by one OR4 or one heterocycloalkyl group, 2) C 3 -C 7 -cycloalkyl, 3) methoxy, 4) —CONH 2 , 5) hydroxy, 6) heteroaryl; 7) CF 3 , 8) phenyl, 9) heterocycloalkyl, and 10) N(CH 3 ) 2 ; R2 is H; R3 is H; R4 is selected from 1) H and 2) C 1 -C 6 -alkyl, where said C 1 -C 6 -alkyl is optionally substituted with one hydroxy or one methoxy group; R5 is selected from 1) C 3 -C 7 -cycloalkyl, 2) C 1 -C 6 -alkyl, where said C 3 -C 7 -cycloalkyl and C 1 -C 6 -alkyl are optionally substituted with one to three substituents selected from R6; each R6 is independently selected from 1) —NR7R8, 2) —CONH 2 , 3) —CN, 4) —OCH 2 CH 2 OR7, 5) C 3 -C 4 alkenyl, 6) OH, 7) C 1 -C 6 -alkoxy, 8) heteroaryl, 9) C 3 -C 7 -cycloalkyl, 10) phenyl, 11) heterocycloalkyl, and 12) halo, where said heteroaryl, cycloalkyl, phenyl and heterocycloalkyl are optionally substituted with one to two substituents selected from R9; R7 is selected from 1) H, 2) C 1 -C 3 -alkyl, and 3) phenyl; R8 is selected from 1) H, 2) C 1 -C 3 -alkyl, and 3) —C(O)R4; each R9 is independently selected from 1) C 1 -C 6 -alkyl; U is a bond; V is 4-piperidinyl substituted by —S(O) 2 R12; and R12 is ethyl or isopropyl; or a pharmaceutically acceptable salt thereof.