Patent ID: 8771346

Claim:
A valve prosthesis for implantation at a native valve of a subject, the prosthesis comprising: a frame expandable from a compressed state to an expanded state, the frame comprising: a first portion configured to be positioned within an annulus of the native valve upon implantation of the prosthesis; a second portion configured to be positioned upstream of the annulus of the native valve, wherein the second portion is configured such that, upon implantation of the prosthesis, the second portion extends radially outward from a proximal portion of the frame, wherein the second portion is configured to be positioned around an inflow side of the annulus of the native valve upon implantation of the prosthesis; a third portion configured to be positioned downstream of the annulus of the native valve, the third portion comprising leaflet engagement members extending from a distal portion of the frame and circumferentially spaced apart to define gaps therebetween, wherein the leaflet engagement members, upon implantation of the prosthesis, are rotationally aligned with leaflets of the native valve and the gaps are rotationally aligned with commissures of the native valve, the gaps being configured to span the width of the commissures of the native valve, the leaflet engagement members being configured such that at least a portion of each leaflet engagement member contacts a downstream side of a leaflet of the native valve upon implantation of the prosthesis; and a prosthetic valve positioned inside and coupled to the frame.