Patent ID: 8470763

Claim:
An α-amino-N-substituted amide compound having a structure represented by following formula, or a pharmaceutically acceptable salt thereof: wherein, R 1 is H or a substituted/unsubstituted C1-C10 alkyl, wherein the substituents of the substituted C1-C10 alkyl are selected from the group consisting of C1-C10 alkoxyl, C1-C10 alkylthio, hydroxyl, aminocarbonyl, C1-C10 alkoxylcarbonyl, C1-C10 alkoxylcarbonylamino, aryl, fused heteroaryl or (1-phenyl C1-4 alkoxylenemethylene)imidazolyl; R 2 is one selected from the group consisting of vinyl C1-C10 alkylene; hydroxyl C1-C10 alkylene; C3-C8 cycloalkyl aminocarbonyl C1-C10 alkylene; C3-C8 cycloalkoxyl carbonyl C1-C10 alkylene; C1-C10 alkoxyl carbonyl C1-C10 alkylene; C1-C10 alkoxyl C1-C10 alkylene; C3-C8 cycloalkoxyl C1-C10 alkylene; phenyl C1-C4 alkoxylene C1-C10 alkylene; C3-C8 saturated or unsaturated cycloalkyl carbonyloxy C1-C10 alkylene; C3-C8 cycloalkyl carbonyl amino C1-C4 alkylene; C3-C8 cycloalkyl C1-C4 alkylene carbonyloxy C1-C10 alkylene; adamantyl carbonyloxy C1-C10 alkylene; phenyl carbonyloxy C1-C10 alkylene; furyl carbonyloxy C1-C10 alkylene; phenyl C1-C4 alkylene carbonyloxy C1-C10 alkylene; C1-C15 alkyl carbonyloxy C1-C10 alkylene; acetenyl C1-C10 alkylene carbonyloxy C1-C10 alkylene; C1-C15 alkoxyl carbonyloxy C1-C10 alkylene; C3-C8 cycloalkoxyl carbonyloxy C1-C10 alkylene; phenyl C1-C10 alkoxylene carbonyloxy C1-C10 alkylene; azido C1-C15 alkylene carbonyloxy C1-C10 alkylene; alkylidyne of formula wherein i is an integer of 1 to 6; spirolactone alkylene of formula wherein m is an integer of 0 to 5, and n is an integer of 0 to 4; and lactone methylene of formula wherein m is an integer of 0 to 5, n is an integer of 0 to 4, and Y is phenyl or a C1-C10 alkyl; R 3 is a C1-C10 alkyl; R 4 is a C1-C5 alkyl; in the case of when the carbon atom connected to R 1 is a chiral carbon atom and/or R 2 contains a chiral carbon atom, the said α-amino-N-substituted amide compound may be a optically pure stereoisomer or a mixture thereof.