Patent ID: 7232813

Claim:
A method of reducing neural loss in a patient in need thereof, comprising administering to the patient an effective amount of a pharmaceutical composition comprising at least one compound of the general formula (1): wherein: R 1 is a group with formula (2) or (3): A is CH 2 , O or S; R 2 and R 3 independently are hydrogen or halogen; R 4 and R 6 independently are hydrogen or a biolabile carboxylic ester forming group; R 5 is selected from (C 1 –C 6 )alkoxy(C 1 –C 6 )alkyl which may be substituted by a (C 1 –C 6 )alkoxy, phenyl-(C 1 –C 6 )-alkyl and phenyloxy-(C 1 –C 6 )-alkyl wherein the phenylgroup may be substituted with (C 1 –C 6 )alkyl, (C 1 –C 6 )-alkoxy or halogen, and naphtyl-(C 1 –C 6 )-alkyl; and R 7 and R 8 independently are hydrogen or a group forming a biolabile phosphonic acid ester; or a stereoisomer, pharmacologically acceptable salt, or prodrugs thereof.