Patent ID: 8501982

Claim:
A method of activation or agonism of a glucagon-like peptide 1 (GLP-1) receptor comprising contacting the receptor with an effective amount of a compound having the structure of Formula I-R or I-S or a pharmaceutically acceptable isomer, enantiomer, racemate, or salt thereof: wherein each R 1 is independently H or C 1-4 alkyl; R 2 is —N(R 1 )—SO 2 —R 8 , —N(R 1 )—(CR a R b ) m —COOH, or —N(R 1 )-tetrazolyl; each R 3 and R 4 is independently H, alkyl, alkoxy, halo, —NO 2 , —CN, perhaloalkyl, perhaloalkoxy, haloalkyl, alkyl substituted with R 31 , —OR 40 , —NR 41 R 42 ;. each R 40 is independently H or alkyl; each R 41 and R 42 is independently H or alkyl, —(CH 2 )—COO—R 40 , —C(O)—R 40 , aryl, heteroaryl, or two taken together with the N atom to which they are attached can form a 3- to 7-membered heterocyclic ring; each R 31 is independently H, halo, hydroxyl, —NR 41 R 42 , or alkoxy; each A is independently, from the proximal to distal end of the structure of Formula I-R or I-S, —(O)—, —OC(O)—, —NR 1 —, —NR 1 —CH 2 —, —C(O)NR 1 —, —N(R 1 )—C(O)—, or —N(R 1 )—S(O 2 )—, W 1 is null or -L 1 -(CR a R b ) m -L 1 -R 6 ; each L 1 is independently, from the proximal to distal end of the structure of Formula I-R or I-S, null, A, —C(O)O—, —S(O 2 )—, —S—, —N(R 1 )—C(O)—N(R 1 )—, —N(R 1 )—C(O)—O—, —C(O)— or —S(O 2 )—NR 1 —; each R a and R b is independently H, alkyl, alkoxy, aralkyl, or two taken together with the carbon to which they are attached form a cycloalkyl; R 6 is H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocycloalkyl, any of which may be optionally singly or multiply substituted with R 7 or —(CH 2 ) m -L 2 -(CH 2 ) m —R 7 ; R 7 is H, halo, alkyl, alkoxy, —OH, —CN, —S(O)—R 8 , —S(O) 2 —R 8 , —S(O) 2 —NR 1 R 8 , —NR 1 —S(O) 2 —R 8 , or a ring moiety selected from cycloalkyl, phenyl, aryl, heteroaryl, heterocyclyl, or heterocycloalkyl, where such ring moiety may be optionally singly or multiply substitutued with halo, alkyl, alkoxy, perhaloalkyl, perhaloalkoxy, haloalkyl, hydroxy, cyano, —S(O)—R 8 , —S(O) 2 —R 8 , —S(O) 2 —NR 1 R 8 , or —NR 1 —S(O) 2 —R 8 ; L 2 is independently, from the proximal to distal end of the structure of Formula I-R or I-S, null, —(O)—, —OC(O)—, —NR 1 —, —C(O)NR 1 —, —N(R 1 )—C(O)—, —S(O 2 )—, —C(O)— or —S(O 2 )—N(R 1 )—; R 5 is R 7 , —(CH 2 ) m -L 2 -(CH 2 ) m —R 7 , or -(-L 3 -(CR a R b ) r —) s -L 3 -R 7 . each L 3 is independently null, —O—, or —N(R 1 )— each R 8 is independently H, C 1-7 alkyl, cycloalkyl or aryl; each m is independently 0, 1, 2, 3, 4, 5, or 6; each n is independently 0 or 1; p is 0, 1, 2, or 3; q is 0, 1, 2, or 3; each r is independently 2, 3, or 4; and each s is independently 1, 2, 3, or 4.