Patent ID: 7807832

Claim:
A method of making a compound of Formula (I): wherein: R 1 and R 2 are each independently selected from the group consisting of —H, —C 1-6 alkyl, —C 3-8 cycloalkyl, benzyl, and 1-methylbenzyl; x is 0, 1, 2, or 3; and each R 3 is independently selected from the group consisting of —OH, —Cl, —F, —C 1-6 alkyl, —C 3-8 cycloalkyl, —OC 1-6 alkyl, —CF 3 , —OCF 3 , phenyl, —CN, —NO 2 , —N(R a )R b , —C(O)N(R a )R b , —N(R c )C(O)R d , —N(R c )SO 2 C 1-6 alkyl, —C(O)C 1-6 alkyl, —S(O) 0-2 C 1-6 alkyl, —SO 2 N(R a )R b , —CO 2 H, and —CO 2 C 1-6 alkyl, where R a and R b are each independently —H or —C 1-6 alkyl, and where R c and R d are each independently —H or —C 1-6 alkyl; or an enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof; comprising: oxidizing an alkyne of Formula (II): with finely powdered potassium permanganate, wherein R 1 , R 2 , R 3 , and x are defined as in compound of Formula (I).