Patent ID: 6916605

Claim:
A method of producing a member of a specific binding pair which comprises a synthetic antibody VH domain encoded by a V, a D, and a J gene segment, which method comprises: expressing in recombinant host cells: a library of nucleic acid sequences encoding a genetically diverse population of specific binding pair members, wherein each specific binding pair member comprises a synthetic antibody VH domain provided by artificial rearrangement of V, D and J gene segments, wherein said specific binding pair members are displayed at the surface of a filamentous bacteriophage particles, and wherein specific binding pair members displayed at the surface of the filamentous bacteriophage particles are in a functional form comprising a binding domain for a complementary specific binding pair member, and wherein genetic material of each bacteriophage particle at the surface of which is displayed a specific binding pair member in a functional form comprising a binding domain for a complementary specific binding pair member encodes said specific binding pair member which is displayed at the surface of the bacteriophage particle or a polypeptide chain of the specific binding pair member which is displayed at the surface of the bacteriophage particle.