Patent ID: 8013184

Claim:
A method for preparing a compound of formula IV: the method comprising (i) reacting a compound of formula I with a compound of formula II under basic conditions in which at least a portion of the phenolic hydroxy group is present in deprotonated form, in an aprotic solvent, to form a compound of formula III to form the compound of formula IV in the case where R 7 is a carboxy group, or to form a compount of formula III in the case where R 7 is not a carboxy group; (ii) converting R 7 in the compound of formula III to a carboxy group to form the compound of formula IV; and wherein n is from 1 to 8; m is from 1 to 4; R 1 is an alkyl group selected from methyl, ethyl, propyl, isopropyl and tert-butyl; each R 2 is independently selected from —OH, NR 3 R 4 , halogen, C 1 , C 2 , C 3 or C 4 alkyl, C 1 , C 2 , C 3 or C4 haloalkyl, C 1 , C 2 , C 3 or C 4 alkoxy, C 2 , C 3 or C 4 alkenyl; each R 5 and each R 6 are independently selected from Hydrogen, —OH, NR 3 R 4 , halogen, C 1 , C 2 , C 3 or C 4 alkyl, C 1 , C 2 , C 3 or C 4 alkoxy, C 2 , C 3 or C 4 alkenyl; R 3 and R 4 are each independently selected from hydrogen, —OH, C 1 , C 2 , C 3 or C 4 alkyl, C 1 , C 2 , C 3 or C 4 haloalkyl, C 1 , C 2 , C 3 or C 4 alkoxy, C 2 , C 3 or C 4 alkenyl; and R 7 is a carboxylic acid or amide group or nitrile group.