Patent ID: 7803823

Claim:
A compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein L is imidazothiazolyl; Q is C 3-6 cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, each of said rings optionally being substituted with up to three substituents each independently selected from halo; hydroxy; cyano; carboxyl; azido; amino; mono- or di(C 1-6 alkyl)amino; C 1-6 alkylcarbonylamino; C 1-6 alkyl; C 2-6 alkenyl; C 2-6 alkynyl; C 3-6 cycloalkyl; C 1-6 alkyl substituted with hydroxy, C 1-6 alkyloxy, amino or mono- or di(C 1-4 alkyl)amino; C 1-6 alkyloxy; C 1-6 alkylthio; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; arylC 1-6 alkyloxy; aryloxy; polyhaloC 1-6 alkyl; polyhalo-C 1-6 alkyloxy; polyhaloC 1-6 alkylcarbonyl; piperidinylamino; 1-methyl-4-piperidinylamino; morpholinyl, C 1-4 alkyl-S(═O) n — or H 2 N—S(═O) n —; and n is an integer of 1 or 2; or Q is a radical of formula and wherein r is an integer from 1 to 3; q is an integer from 1 to 4; X and Y are each independently O, NR 3 , CH 2 or S, with R 3 being hydrogen or C 1-4 alkyl; W is O or NR 4 , with R 4 being hydrogen or C 1-4 alkyl; and wherein aryl is phenyl, optionally substituted with up to five substituents each independently selected from halo, hydroxy, C 1-6 alkyl, polyhaloC 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, cyano, nitro, amino or mono- or di(C 1-6 alkyl)amino; and Z is halo; C 1-6 alkyl; C 1-6 alkyl substituted with amino; C 1-6 alkyl substituted with hydroxy; 4-piperidinylaminomethyl; or 1-methyl-4-piperidinylaminomethyl.