Patent ID: 6949569

Claim:
Dual molecules comprising coupling products complying with the formula (I) wherein A represents a residue of a molecule with anti-malarial activity, wherein A is selected from the group consisting of molecules (IIa) and (IIb), and wherein (IIa) comprises Y 1 and Y 2 , identical or different, represent a linear or ramified alkylene chain at C1 to C5, containing if applicable one or more amine, amide, sulfonamide, carboxyl, hydroxyl, ether or thioether radicals, with the possibility of either Y 1 or Y 2 being absent; U is an amine function, said function linking Y 1 and Y 2 ; Z 1 and Z 2 , identical or different, represent a saturated or unsaturated, linear, ramified or cyclic alkylene radical, with the possibility of either Z 1 or Z 2 being absent, or Z 1 +Z 2 together represent a polycyclic structure including the junction carbons Ci and Cj; R 1 and R 2 , identical or different, represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, advantageously selected from —COOH, —OH, —N(R a , R b ) where R a and R b , identical or different, represent a hydrogen atom or alkyl radical at C1 to C5; R x or R y form a cyclic peroxide with 4 to 8 chain links, which may comprise 1 to 2 additional oxygen atoms in the cyclic structure, Cj being one of the peaks of said cyclic peroxide, or; R 3 represents one or more identical or different substituents occupying separate positions, at least one representing a halogen atom, an —OH group, a —CF 3 group, an aryl radical, an alkyl or alkoxy radical at C 1 to C 5 , a —NO 2 group, the other substituent or substituents having one of these correspondences or a hydrogen atom; R 4 represents a linear, ramified or cyclic alkyl radical at C1 to C5, or a hydrogen atom; and their addition salts with pharmacological acceptable acids.