Patent ID: 7795265

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein X is N or CR 16 ; R 1 , R 2 , R 3 and R 4 are each selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —OH, (4) —C 1-6 alkyl, and (5) —C 1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to five substituents selected from halogen, OH, C 1-6 alkyl, and C 1-6 alkoxy, and R 2 and R 3 or R 3 and R 4 together with the atoms to which they are attached form a 4-8 membered ring containing 0-2 heteroatoms independently selected from oxygen, and wherein the 4-8 membered ring is unsubstituted or substituted with a substituent selected from OH, halogen, C 1-6 alkyl, and C 1-6 alkoxy; R 5 , R 6 and R 7 are each independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —C 1-6 alkyl, and (4) —C 1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to five substituents selected from halogen, OH, C 1-6 alkyl, and C 1-6 alkoxy; R 8 is hydrogen; R 9 is hydrogen; each R 10 is independently selected from the group consisting of: (1) Cl, (2) —CH═CHCO 2 H, (3) —C(O)morpholine, (4) —C(O)pyrrolidine, (5) —C(O)piperidine, (6) —CO 2 H, (7) —CO 2 CH 2 phenyl, (8) —CO 2 CH 3 , (9) —(CH 2 ) 2 CO 2 H, (10) —CO 2 tetrahydropyran, (11) —CONH 2 , (12) —CONHCH 3 , (13) —CONHCH 2 CH 3 , (14) —CON(CH 2 CH 3 ) 2 , (15) —CON(CH 3 ) 2 , (16) —CONHCH(CH 3 ,) 2 , (17) —CONHcyclopropyl, (18) —CONHphenyl, (19) —C(O)NHcyclopentyl, (20) —C(O)NH(CH 2 ) 1-6 OH, (21) —C(O)NHtetrahydropyran, (22) —CONHCH 2 CO 2 H, (23) —CON(CH 3 )CH 2 CO 2 H, (24) —CONHCOC(CH 3 ) 3 , (25) —C(O)NHCH(CO 2 CH 2 phenyl) 2 , (26) —C(O)NHCH(CO 2 CH 2 CH 3 ) 2 , and (27) tetrazole, wherein the alkyl, alkene, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl substituents and —(CH 2 ) n as described in the above R 10 substituents are unsubstituted or substituted with one to eight substituents selected from —C 1-6 alkyl, oxo, halogen, —C 1-6 alkoxy, —(CH 2 ) n OH, —(CH 2 ) n CN, —(CH 2 ) n CF 3 , —(CH 2 ) n SO 3 H, —(CH 2 ) n CO 2 H, —(CH 2 ) n CO 2 C 1-6 alky, and —(CH 2 ) n CO 2 C 2-6 alkene, and alkyl and alkoxy are unsubstituted or substituted with one to five substituents independently selected from halogen, —OH, —SO 3 H, —CO 2 H, and —CO 2 C 1 - 6 alkyl; R 16 is selected from the group consisting of: hydrogen, —OH, —C 1-6 alkyl unsubstituted or substituted with —OH or phenyl, and —C 1-6 alkoxy; each n is independently 0, 1, 2, 3, 4, 5, 6, 7 or 8; and m is 1 and p is 0.