Patent ID: 8193194

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R′ 1 and R 1 are independently —Z A R 4 , wherein each Z A is independently a bond or an optionally substituted branched or straight C 1-12 aliphatic chain wherein up to three carbon units of Z A are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NR A —, —C(O)NR A NR A —, —C(O)O—, —NR A C(O)O—, —O—, —NR A C(O)NR A —, —NR A NR A —, —S—, —SO—, —SO 2 —, —NR A —, —SO 2 NR A —, or —NR A SO 2 NR A —; R 4 is independently R A , halo, —OH, —CN, —NO 2 , —NH 2 , or —OCF 3 ; R A is independently hydrogen, an optionally substituted aryl, or an optionally substituted heteroaryl; or R′ 1 and R 1 together with the nitrogen atom to which they are attached form a heterocycloaliphatic that is substituted with two of —Z B R 5 , wherein each Z B is independently a bond or an optionally substituted branched or straight C 1-6 aliphatic chain wherein up to three carbon units of Z B are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NR B —, —C(O)NR B NR B —, —C(O)O—, —NR B C(O)O—, —O—, —NR B C(O)NR B —, —NR B NR B —, —S—, —SO—, —SO 2 —, —NR B —, —SO 2 NR B —, or —NR B SO 2 NR B —; R 5 is independently R B , halo, —OH, —CN, —NO 2 , —NH 2 , ═O, or —OCF 3 ; R B is independently hydrogen, or an optionally substituted heteroaryl; R 2 is —Z C R 6 , wherein each Z C is independently a bond or an optionally substituted branched or straight C 1-6 aliphatic chain wherein up to two carbon units of Z C are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NR C —, —C(O)NR C NR C —, —C(O)O—, —NR C C(O)O—, —O—, —NR C C(O)NR C —, —NR C NR C —, —S—, —SO—, —SO 2 —, —SO 2 NR C —, or —NR C SO 2 NR C —; R 6 is independently R C , halo, —OH, —CN, —NO 2 , —NH 2 , or —OCF 3 ; R C is independently hydrogen, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl; R 3 is —Z D R 7 , wherein each Z D is independently a bond or an optionally substituted branched or straight C 1-6 aliphatic chain wherein up to two carbon units of Z D are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NR D —, —C(O)NR D NR D —, —C(O)O—, —NR D C(O)O—, —O—, —NR D C(O)NR D —, —NR D NR D —, —S—, —SO—, —SO 2 —, —NR D —, —SO 2 NR D —, or —NR D SO 2 NR D —; R 7 is independently R D , halo, —OH, —CN, —NO 2 , —NH 2 , or —OCF 3 ; and R D is independently hydrogen, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl.