Patent ID: 8685967

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein â€”Xâ€”Yâ€” is â€”Nâ•C(R 4 )â€”, â€”C(R 4 )â•Nâ€”; R 1 is H, halo, alkyl, alkoxy, â€”CF 3 , cycloalkyl, alkoxyalkoxy, OH, hydroxyalkyl, â€”OCF 3 , â€”O-cycloalkyl, benzyloxy, â€”C(O)Oalkyl, â€”O-alkyl-CO 2 H, â€”C(O)N(R 6 ) 2 , â€”N(R 6 ) 2 , -alkylN(R 6 ) 2 , â€”NR 6 â€”C(O)N(R 6 ) 2 , â€”N(R 6 )C(O)Oalkyl, â€”N(R 6 )SO 2 -alkyl, CN, â€”SF 5 , â€”OSF 5 , â€”SO 2 R 6 , â€”SR 6 , trimethylsilylphenyl, aryl, â€”Câ‰¡Câ€”CH 2 OH, â€”Câ‰¡C-aryl, arylalkyl-, â€”C(O)NHCH 2 -aryl, heteroaryl, â€”Câ‰¡C-heteroaryl, heteroarylalkyl-, â€”C(O)NHCH 2 -heteroaryl, R 1A is H, halo, alkyl, alkoxy, â€”CF 3 , cycloalkyl, alkoxyalkoxy, OH, hydroxyalkyl, â€”OCF 3 , â€”O-cycloalkyl, benzyloxy, â€”C(O)Oalkyl, â€”O-alkyl-CO 2 H, â€”C(O)N(R 6 ) 2 , â€”N(R 6 ) 2 , -alkylN(R 6 ) 2 , â€”NR 6 â€”C(O)N(R 6 ) 2 , â€”N(R 6 )C(O)Oalkyl, â€”N(R 6 )SO 2 -alkyl, CN, â€”SF 5 , â€”OSF 5 , â€”SO 2 R 6 , â€”SR 6 , trimethylsilylphenyl, â€”Câ‰¡Câ€”CH 2 OH, â€”Câ‰¡C-aryl, or arylalkyl-; Q is â€”Oâ€”, â€”N(R 10 )â€”, â€”Sâ€”, â€”SOâ€”, â€”SO 2 â€” or â€”CH 2 â€”; Z is: â€”(CH(R 2 )) n â€”(CH(R 2A )) m â€”, optionally substituted by 1 or 2 alkyl groups, or optionally substituted by 1 or 2 alkyl groups, wherein G is â€”N(R 8 )â€”, â€”Oâ€” or â€”Sâ€”; or â€”N(R 5 )â€” and â€”Zâ€” together form a 4 to 7 membered ring optionally substituted by 1 or 2 alkyl groups; n is 1 or 2; m is 0, 1 or 2; p is 0, 1 or 2; q is 0, 1, 2 or 3; each R 2 is independently selected from the group consisting of H, alkyl or cycloalkyl; each R 2A is independently selected from the group consisting of H, alkyl, cycloalkyl, fluoro, OH, alkoxy, â€”N(R 8 ) 2 or -alkyl-N(R 8 ) 2 ; R 3 is selected from the group consisting of pyridine, pyrazine, each R 4 is independently selected from the group consisting of H, alkyl, cycloalkyl, halo, â€”CF 3 , alkoxyalkyl, heteroaryl, â€”CN, hydroxyalkyl, aryl, arylalkyl-, heteroarylalkyl-, â€”OCF 3 , â€”SF 5 , â€”OSF 5 and â€”N(R 6 ) 2 ; R 5 is H, alkyl or cycloalkyl; each R 6 is independently selected from the group consisting of H, alkyl, cycloalkyl and arylalkyl; R 7 is 1 or 2 substituents independently selected from the group consisting of H, halo, alkyl, alkoxy, â€”CF 3 , cycloalkyl, alkoxyalkoxy, OH, hydroxyalkyl, â€”OCF 3 , â€”O-cycloalkyl, benzyloxy, â€”C(O)Oalkyl, â€”O-alkyl-CO 2 H, â€”C(O)N(R 6 ) 2 , â€”N(R 6 ) 2 , -alkylN(R 6 ) 2 , â€”NR 6 â€”C(O)N(R 6 ) 2 , â€”N(R 6 )C(O)Oalkyl, â€”N(R 6 )SO 2 -alkyl, phenyl, CN, â€”SF 5 , â€”OSF 5 , â€”SO 2 R 6 , â€”SR 6 and trimethylsilyl; each R 8 is independently selected from the group consisting of H and alkyl; R 9 is 1 to 3 substituents independently selected from the group consisting of H and alkyl, and when Q is â€”CH 2 â€”, R 9 can also be halo, OH, alkoxy or â€”CF 3 ; and R 10 is H, alkyl, â€”C(O)N(R 6 ) 2 , â€”C(O)Oalkyl, or â€”SO 2 -alkyl.