Patent ID: 7932234

Claim:
A method for treating a CNS malignancy in a subject suffering from a CNS malignancy, comprising administering to the subject an antisense oligonucleotide, wherein substantially all of the antisense oligonucleotide is complementary to a portion of a gene encoding IGFBP-2 and substantially all of the oligonucleotide is also complementary to a gene encoding IGFBP-5, and wherein the oligonucleotide is of sufficient length to act as an antisense inhibitor of IGFBP-2 and IGFBP-5, and wherein the antisense oligonucleotide is administered in an amount effective to reduce levels of IGFBP-2 and IGFBP-5 in cells of the CNS malignancy, and wherein said CNS malignancy is a glioma.