Patent ID: 7741457

Claim:
An oligomeric compound having at least one monomer of formula: or of formula: or of formula: wherein independently for each of said at least one monomer of formula I, II or III: Bx is a heterocyclic base moiety; T 3 and T 4 are each, independently, an internucleoside linking group linking the monomer to the oligomeric compound or one of T 3 and T 4 is an internucleoside linking group linking the monomer to the oligomeric compound and the other of T 3 and T 4 is H, a hydroxyl protecting group or a linked conjugate group; Z is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl, substituted C 2 -C 6 alkynyl, acyl, substituted acyl, substituted amide, thiol or substituted thiol; each substituted group is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, oxo, hydroxyl, OJ 1 , NJ 1 J 2 , SJ 1 , N 3 , OC(═X)J 1 , OC(═X)NJ 1 J 2 , NJ 3 C(═X)NJ 1 J 2 and CN, wherein each J 1 , J 2 and J 3 is, independently, H or C 1 -C 6 alkyl, and X is O, S or NJ 1 ; wherein said oligomeric compound further comprises at least one monomeric subunit selected from a β-D-2′-deoxyribonucleoside, a β-D-ribonucleoside and a nucleoside having a modified sugar moiety wherein each of said modified sugar moieties is, independently, selected from a modified sugar moiety that is substituted with a substituent group, substituted at the 4′-O with a 4′-S, 4′-amino or C 1 -C 6 aminoalkyl, or bridged to form a bicyclic nucleic acid (BNA); wherein said oligomeric compound comprises from 8 to 40 nucleosides and/or modified nucleosides or mimetics in length.