Patent ID: 7968707

Claim:
A process for the preparation of a compound of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof, said process comprising reacting a compound of the formula: with a compound of the formula: or a salt or activated ester derivative thereof, wherein: R 1 and R 2 are independently selected from the group consisting of loweralkyl, cycloalkylalkyl and arylalkyl; R 3 is loweralkyl, hydroxyalkyl or cycloalkylalkyl; R 4 is aryl; R 5 is wherein n is 1, 2 or 3, X is O, S or NH, and Y is —O— or —N(R 6 )— wherein R 6 is hydrogen, loweralkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl; and L 1 is selected from the group consisting of: a) —O—, b) —S—, c) —N(R 7 )— wherein R 7 is hydrogen loweralkyl, cycloalkyl or cycloalkylalkyl, d) —O-alkylenyl-, e) —S-alkylenyl-, f) —S(O)-alkylenyl-, g) —S(O) 2 -alkylenyl-, h) —N(R 7 )-akylenyl- wherein R 7 is defined as above, i) -alkylenyl-O—, j) -alkylenyl-S—, k) -alkylenyl-N(R 7 )— wherein R 7 is defined as above, l) -alkylenyl-, and m) -alkenylenyl-.