Patent ID: 8624027

Claim:
A combination of therapeutic agents for use in treating a patient suffering from cancer, wherein said combination comprises: a) at least one polyploidy inducing agent for use in inducing polyploidization in one or more cancer cells in the patient; and b) at least one Bcl-2 family protein inhibitor having the following structure (II): or a therapeutically acceptable salt thereof; wherein X 3 is chloro or fluoro; and (1) X 4 is azepan-1-yl, morpholin-1-yl, 1,4-oxazepan-4-yl, pyrrolidin-1-yl, N(CH 3 ) 2 , N(CH 3 )(CH(CH 3 ) 2 ), 7-azabicyclo[2.2.1]heptan-1-yl or 2-oxa-5-azabicyclo[2.2.1]hept-5-yl; and R 0 is wherein X 5 is CH 2 , C(CH 3 ) 2 or CH 2 CH 2 ; X 6 and X 7 are both hydrogen or both methyl; and X 8 is fluoro, chloro, bromo or iodo; or, (2) X 4 is azepan-1-yl, morpholin-1-yl, pyrrolidin-1-yl, N(CH 3 )(CH(CH 3 ) 2 ), or 7-azabicyclo[2.2.1]heptan-1-yl; and R 0 is wherein X 6 and X 7 are both hydrogen or both methyl; and X 8 is fluoro, chloro, bromo or iodo; or, (3) X 4 is N(CH 3 ) 2 or morpholin-1-yl; and R 0 is wherein X 8 is fluoro, chloro, bromo or iodo.