Patent ID: 7126021

Claim:
Process for the manufacture of compounds of general formula: in which R 1 and R 2 , which are identical or different, represent a hydrogen atom, a linear, branched or cyclic alkyl radical having a number of carbon atoms ranging from 1 to 10, an aryl radical, or an aralkyl radical having a number of carbon atoms ranging from 1 to 10, or else R 1 and R 2 are connected to one another so as to form a ring which includes the carbon atom carrying the said R 1 and R 2 radicals, the said ring having a number of carbon atoms, including the carbon carrying the R 1 and R 2 radicals, ranging from 3 to 8; R 3 represents a linear or branched and saturated or unsaturated hydrocarbonaceous radical which can comprise at least one ring, the said radical having a number of carbon atoms ranging from 1 to 30; and R 4 and R 5 , which are identical or different, represent a linear or branched alkyl radical having a number of carbon atoms ranging from 1 to 20 or a cycloalkyl, aryl, alkoxyl, aryloxyl, aralkyloxyl, perfluoroalkyl, aralkyl, dialkyl- or diarylamino, alkylarylamino or thioalkyl radical, or else R 4 and R 5 are connected to one another so as to form a ring which includes the phosphorus atom, the said heterocycle having a number of carbon atoms ranging from 2 to 4 and being able in addition to comprise one or more oxygen, sulphur or nitrogen atoms; the said process consisting in oxidizing an aminophosphonate of formula in a solvent medium using a nonhalogenated organic peracid in a water/solvent two-phase medium with an aqueous phase buffered at a pH ranging from 5 to 12; the said aminophosphonate being obtained by reaction of a carbonyl compound R 1 R 2 C(O), of a primary amine R 3 NH 2 and of a phosphorus compound HP(O)R 4 R 5 , R 1 , R 2 , R 3 , R 4 and R 5 having the meanings given above, by carrying out the following (successive) stages: a) a carbonyl compound R 1 R 2 C(O) is reacted with a primary amine R 3 NH 2 according to an R 1 R 2 C(O)/R 3 NH 2 molar ratio of between 0.8 and 1.5 and preferably of between 0.9 and 1.1 at a temperature of between 0° C. and 120° C. and a pressure ranging from 1 to 10 bar; then the water formed is removed from the reaction medium; and b) the compound obtained in a) is reacted with a phosphorus compound HP(O)R 4 R 5 ; the said process being characterized in that stage b) is carried out in the presence of a Lewis acid using an HP(O)R 4 R 5 /compound obtained in stage a) molar ratio substantially equal to 1 at a temperature at most equal to 100° C. and in that the medium obtained in b) is subjected directly and without purification to an oxidation reaction carried out according to the conditions mentioned above.