Patent ID: 7501255

Claim:
A method of detecting cancer in a mammal, comprising assessing the level of Pin1 protein having the amino acid sequence set forth in SEQ ID NO: 2 in a test sample from the mammal, and comparing the level of Pin1 protein in the test sample to the level of Pin1 protein in a control sample comprising corresponding normal cells, wherein the level of Pin1 protein in the test sample and the control sample is assessed by contacting the test sample and the control sample with an antibody that binds to the amino acid sequence set forth in SEQ ID NO:2 under conditions suitable for binding of the antibody, and wherein a lower level of Pin1 protein in the test sample compared to the level of Pin1 protein in the control sample is indicative that the mammal has cancer selected from the group consisting of endometroid carcinoma, endometrium serous carcinoma, adrenal gland adenoma, pheochromocytoma, pancreatic adenocarcinoma, small intestine adenocarcinoma, stomach diffuse adenocarcinoma, kidney chromophobic carcinoma, kidney oncocytoma, kidney papillary carcinoma, kidney clear cell carcinoma, testis non-seminomatous cancer, testis seminoma and Hodgkin's lymphoma.