Patent ID: 8232396

Claim:
A process for the preparation of a compound of Formula (II): the process comprising: (a) forming a reaction mixture by combining a compound of Formula (I), with a dienophile and a solvent comprising an alcohol and at least 10% water, wherein the compound of Formula (I) is: and (b) heating the reaction mixture to form a compound of Formula (II), wherein: R 1 and R 8 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; R 2 and R 3 are independently selected from the group hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {—}OH, {—}NH 2 , {—}SH, {—}SR 8 , and {—}OR 8 ; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; and X is oxygen.