Patent ID: 7339035

Claim:
A recombinant antibody or antigen-binding fragment thereof having specificity for GM1 ganglioside-bound amyloid β-protein and which inhibits the formation of amyloid fibrils comprising: a heavy chain variable region; and a light chain variable region, wherein the heavy chain variable region comprises complementarity determining regions (CDRs) described in g), h) and i), and the light chain variable region comprises CDRs described in j), k) and l); g) CDR 1 consisting of the amino acid sequence of SEQ ID NO. 1; h) CDR 2 consisting of the amino acid sequence of SEQ ID NO. 2; i) CDR 3 consisting of the amino acid sequence of SEQ ID NO. 3; j) CDR 1 consisting of the amino acid sequence of SEQ ID NO. 4; k) CDR 2 consisting of the amino acid sequence of SEQ ID NO. 5; and l) CDR 3 consisting of the amino acid sequence of SEQ ID NO. 6.