Patent ID: 8623891

Claim:
A method for treating a cognitive disorder, the method comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one compound of the following structure: an enantiomer, a diastereomer, racemic mixture, or a pharmaceutically acceptable salt thereof; where: R 1 and R 2 groups together with the nitrogen form a saturated 5 or 6 membered ring, said 5 or 6 membered ring optionally being substituted with one or two COOH, CH 2 OH, OH, B(OH) 2 , halogen groups, cyano groups, or with one or two alkyl groups having 1 to 6 carbons; R 3 is independently selected from the group consisting of H, and alkyl of 1 to 20 carbons; R 4 is H, or alkyl of 1 to 6 carbons; the wavy lines represent bonds connected to carbons having R or S configuration; the dashed lines represent a bond or absence of a bond with the proviso that the ring containing the dashed lines is aromatic; m, n and q are independently 1; s is zero (0); X represents N; W, and Y independently represent CH; R 5 and R 6 are independently selected from the group consisting of H, halogen, alkyl of 1 to 6 carbons, halogen substituted alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons, thioxy of 1 to 3 carbons, and phenyl; or R 5 and R 6 together with the atoms to which they are attached jointly form a carbocyclic ring, the carbocyclic ring having 5 or 6 atoms in the ring; said carbocyclic ring jointly formed by R 5 and R 6 and the atoms to which they are attached being optionally substituted with 1 to 6 R 9 groups where R 9 is independently selected from the group consisting of halogen, alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons and thioxy of 1 to 3 carbons; and wherein said cognitive disorder is associated with a neurodegenerative disease selected from the group consisting of Alzheimer's disease, corticobasal degeneration, Creutzfeldt-Jacob disease, frontotemporal lobar degeneration, Huntington disease, multiple sclerosis, normal pressure hydrocephalus, organic chronic brain syndrome, Parkinson's disease, Pick disease, progressive supranuclear palsy, and senile dementia (Alzheimer type).