Patent ID: 7629331

Claim:
A composition comprising an excipient and a sulfoalkyl ether cyclodextrin composition, wherein the sulfoalkyl ether cyclodextrin composition comprises: (a) sulfoalkyl ether cyclodextrin; (b) no more than about 20% by weight moisture; (c) a bulk density of about 0.38 g/cm 3 to about 0.66 g/cm 3 ; (d) a tapped density of about 0.49 g/cm 3 to about 0.75 g/cm 3 , wherein the tapped density of the sulfoalkyl ether cyclodextrin composition is higher than the bulk density; and (e) a gravitational-flow minimum orifice diameter of about 3 mm to about 12 mm; and wherein the sulfoalkyl ether cyclodextrin composition comprises agglomerated particles, wherein the agglomerated particles are produced by a process comprising: (i) forming a fluidized bed of SAE-CD particles in a drying chamber of a fluidized bed spray dryer apparatus with an attached 3-chamber fluidization bed; (ii) recycling fine particles from the fluidized bed back into the drying chamber at a location adjacent to a liquid feed atomizer; and (iii) collecting agglomerated particles from the third chamber of the 3-chamber fluidization bed.