Patent ID: 8415095

Claim:
An immunogen comprising a 5′-O-citrate derivative of a nucleoside in which a 5′-O-(3,4-dicarboxy-3-hydroxy)butanoate-2′,3′-dideoxy nucleoside is coupled to a carrier molecule through a carboxy group of the 5′-O-derivative, or a nucleoside analog in which an O-(3,4-dicarboxy-3-hydroxy)butanoate ester group formed from the O atom of a —CH 2 —OH group in the nucleoside analog is coupled to a carrier molecule through a carboxy group of the O-(3,4-dicarboxy-3-hydroxy)butanoate ester group, and which elicits antibodies that bind triphosphorylated nucleosides or triphosphorylated nucleoside analogs.