Patent ID: 7534890

Claim:
A process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one salt comprising: (i) reacting 8-substituted oxy-5-(R)-oxiranyl-(1H)-quinolin-2-one having Formula (I) with 2-amino-(5-6-diethyl)-indan to form a reaction mixture containing compounds having Formulae (II), (III) and (IV) wherein R is a protecting group; (ii) treating the reaction mixture prepared in Step (i) with an acid in the presence of a solvent to form a corresponding salt; (iii) isolating and crystallizing a salt having Formula (V) wherein R is a protecting group and A − is an anion; (iv) removing the protecting group from the salt having Formula (V) in the presence of a solvent to form a salt having Formula (VI): wherein A − is an anion; and (v) treating the salt having Formula (VI) with an acid in the presence of a solvent to form a 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one salt having Formula (VII) wherein X − is an anion.