Patent ID: 7642361

Claim:
A compound of Formula I: wherein X represents S; R 1 represents hydrogen, F, Cl, Br, I, CHO, —CN, —S(phenyl), CF 3 , -(1-4C)alkyl, -(1-4C)alkoxy, —S(1-4C)alkyl, —SO(1-4C)alkyl, —SO 2 (1-4C)alkyl, —C(═O)(1-3C)alkyl, NH 2 , —NH(1-4C)alkyl, —N[(1-4C)alkyl] 2 , —NH(4-7C)cycloalkyl, or —N[(1-4C)alkyl](CH 2 ) r N[(1-4C)alkyl] 2 ; R 2 represents —CO 2 H; R 4 represents hydrogen, OH, —CH 2 OH, —CH 2 CH 2 OH, —CH 2 O(1-4C)alkyl, F, Cl, CF 3 , OCF 3 , —CN, NO 2 , NH 2 , —CH 2 NH 2 , -(1-4C)alkyl, -(1-4C)alkoxy, —C(═O)NH(1-4C)alkyl, —C(═O)NH 2 , —CH 2 C(═O)NH 2 , —NHC(═O)(1-4C)alkyl, —(CH 2 ) m NHSO 2 R 10 , —(CH 2 ) n CN, —(CH 2 ) m CO 2 H, —C(═NOH)CH 3 , —(CH 2 ) m CO 2 (1-6C)alkyl, —C(═O)H, —C(═O)(1-4C)alkyl, —NH(1-4C)alkyl, —N[(1-4C)alkyl] 2 , —SR 10 , —SOR 10 , —SO 2 R 10 , SH, —CH 2 SO 2 NH 2 , —CH 2 NHC(═O)CH 3 , R 5 represents hydrogen, F, Cl, —CN, NO 2 , NH 2 , —(CH 2 ) m NHSO 2 R 10 , -(1-4C)alkyl, or -(1-4C)alkoxy; R 6 represents hydrogen, -(1-4C)alkyl, —SO 2 R 11 , or —C(═O)(1-4C)alkyl; R 7 represents hydrogen or -(1-4C)alkyl; R 8 represents hydrogen, F, Cl, Br, -(1-4C)alkyl, -(1-4C)alkoxy, NO 2 , NH 2 , —CN, —NHSO 2 R 11 , or —C(═O)(1-4C)alkyl; R 8a represents hydrogen, F, Cl, Br, -(1-4C)alkyl, NO 2 , NH 2 , NH(1-6C)alkyl, N[(1-6C)alkyl] 2 , —C(═O)NH 2 , —CN, —CO 2 H, —S(1-4C)alkyl, —NHCO 2 (1-4C)alkyl, —C(═O)NHCH 2 CH 2 CN, or —C(═O)(1-4C)alkyl; R 10 , R 11 , and R 12 each independently represent -(1-4C)alkyl, —(CH 2 ) 3 Cl, CF 3 , NH 2 , NH(1-4C)alkyl, N[(1-4C)alkyl)] 2 , thienyl, phenyl, —CH 2 phenyl, or (CH 2 ) 2 phenyl, wherein phenyl, as used in substituent R 10 , R 11 or R 12 , is unsubstituted or substituted with F, Cl, Br, CF 3 , -(1 -4C)alkyl, -(1-4)alkoxy, or acetyl; R 13 represents hydrogen, -(1-4C)alkyl, —CH 2 CF 3 , triazole, or tetrazole; R 14 represents -(1-4C)alkyl; R 15 represents hydrogen or -(1-4C)alkyl; R 19 represents (1-4C)alkyl or CF 3 ; m represents 0, 1, 2, or 3; n represents 1, 2, 3, or 4; p represents 1 or 2; r represents 1 or 2; and A is selected from the group consisting of —(CH 2 ) 2 NHSO 2 R 12 , —CH(CH 3 )(CH 2 )NHSO 2 R 12 , —(CH 2 )CH(CH 3 )NHSO 2 R 12 , and the pharmaceutically acceptable salts thereof.