Patent ID: 7056530

Claim:
A selfemulsifiable formulation for oral administration, wherein said formulation is consisting essentially of immunosuppression agent, hydrophilic agent, lipophilic agent, surfactants, antioxidant and preservative, wherein said immunosuppression agent is cyclosporine-A having immunosuppression activity and is taken in an amount of about 2 to 10% by weight of the formulation; said hydrophilic agent is consisting essentially of ethanol taken in a weight ratio of about 1:0.5 to 1:2.5 with respect to said immunosuppression agent; said lipophilic agent is medium chain triglycerides of caprylic and capric acids taken in a ratio of immunosuppression agent to lipophilic agent of about 1:1.5 or about 1:1.7 by weight; said surfactants are combination of polyglycolised transesterified caprylic and capric glycerides having a hydrophilic lipophilic balance (HLB) of about 14 and a saponification value of about 85 to 105, polysorbate 80 and cremophor RH 40; said antioxidant is selected from the group consisting of alpha-tocopherol ascorbyl palmitate, butyl hydroxy anisole, butyl hydroxy toluene, and propyl gallate; and said preservative is selected from one of ethanol and benzyl alcohol wherein said formulation forms microemulsions of particle size less than 200 nm on contact with gastric juice or aqueous medium.