Patent ID: 8318798

Claim:
A method for treating Parkinson's disease using a compound with a binding energy to the active site of DJ-1 protein being −60 kcal/mol or below, wherein the compound is represented by the following Formula: wherein, R 9 to R 11 may be identical to or different from each other, and denote a hydrogen atom, a hydroxy group, an alkoxy group, an aryloxy group, an acyloxy group (—O—CO—R 14 , R 14 denotes an alkyl group having 1 to 6 carbons or an aryl group) or a sulfonyloxy group (—O—SO 2 —R 15 , R 15 denotes an alkyl group having 1 to 6 carbons or an aryl group), or alternatively R 9 and R 13 may together form the following Formulae: R 12 denotes a hydrogen atom or —(CONH)pR 16 (wherein R 16 denotes an alkyl group, an aryl group or —CH(CONH 2 ) g (CH 2 SO 2 NH 2 ) r (CH 2 CH(CH 3 ) 2 ) s (wherein, q, r and s denote integers of 0 to 2 that satisfy q+r+s=2), and p denotes 1 or 2), R 13 denotes a hydrogen atom, a hydroxy group, or an alkoxy group, n denotes an integer of 0 to 2, o denotes 0 or 1, and n+o=1 or 2.