Patent ID: 7776847

Claim:
A compound of Formula II, or a pharmaceutically acceptable salt or S-oxide thereof, wherein, each R 1 is independently selected from —H, halogen, mono- to trihalomethyl, —NO 2 , —N(R 3 )R 3 , —S(O) 0-2 R 3 , —SO 2 N(R 3 )R 3 , optionally substituted C 1-12 alkoxy, optionally substituted C 1-6 alkyl, and optionally substituted aryl C 0-6 alkyl B is selected from absent, optionally substituted C 1-6 alkylene, —C═O, —C(═O)C(═O)—, —S(O) 2 , —C(═O)N(R 4 )—, —C(═NR 5 )N(R 4 )—, —C(═S)N(R 4 )—, —C(═S)O—, and —C(═O)O— R 2 is an optionally substituted aryl-aryl; each R 3 is independently selected from —H, optionally substituted C 1-6 alkyl, optionally substituted —C(═O)C 1-6 alkyl, optionally substituted aryl C 0-6 alkyl, optionally substituted heteroaryl C 0-6 alkyl and optionally substituted heterocyclyl C 0-6 alkyl; optionally two of R 3 , together with the nitrogen to which they are attached, combine to form an optionally substituted heterocyclyl containing one to three heteroatoms; each R 4 is independently selected from —H and optionally substituted C 1-6 alkyl, —S(O) 0-2 R 3 , —C(═O)N(R 3 )(R 3 ), optionally substituted aryl C 1-6 alkyl; each R 5 is independently selected from —H, —CN, —NO 2 , —OR 3 , —S(O) 0-2 R 3 , —CO 2 R 3 , optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, and optionally substituted C 2-6 alkynyl; M is C 2-4 alkylene, C 2-4 alkenylene, or C 2-4 alkynylene; and each R 9 is independently selected from —H, optionally substituted C 1-6 alkyl, optionally substituted aryl C 0-6 alkyl and optionally substituted heterocyclyl C 0-6 alkyl; and optionally two of R 9 , together with the nitrogen to which they are attached, combine to form an optionally substituted heterocyclyl containing one to three heteroatoms.