Patent ID: 8148496

Claim:
A monospecific, homodimeric and tetravalent F v antibody formed by two single-chain F v monomers of the same kind, each of the single-chain F v monomer having the structure: V H -peptide linker 1-V L -peptide linker 2-V H -peptide linker 3-V L , wherein with the proviso that each F v monomer does not have constant domains; V H and V L are heavy chain and light chain variable domains of an antibody specific for an antigen, respectively; peptide linker 1 is a peptide bond or has 1 to about 10 amino acids; peptide linker 2 has about 3 to 10 amino acids; peptide linker 3 is a peptide bond or has 1 to about 10 amino acids; and each V H of one of the single-chain F v monomers associates intermolecularly with each V L of the other single-chain F v monomer, thereby forming said homodimeric and tetravalent Fv antibody having four antigen binding sites for the same antigen.