Patent ID: 7867753

Claim:
A method of detecting interactions between species on a solid support and species in a liquid, comprising providing a solid support having at least two non-overlapping defined portions, wherein a first species is attached on at least one of said defined portions and at least one other defined portion is an area of the solid support where no interaction takes place, said other portion defining a reference area, wherein the detection of interactions comprises for each defined portion: exposing the defined portion to a liquid containing a second species, so as to cover the defined portion of the solid support; temporarily reducing the amount of said liquid being in contact with the defined portion, said reduction being carried out so that a reduced volume of said liquid remains in contact with said defined portion; performing a measurement of the defined portion covered with the temporarily reduced amount of liquid, said measurement being capable of detecting an interaction between said first and said second species; increasing the amount of liquid in contact with the defined portion so as to again expose the defined portion to said liquid containing a second species; and repeating the exposing to a liquid, reducing the amount of liquid, performing a measurement and increasing the amount of liquid; wherein the liquid in contact with the solid support is stirred; and wherein the non-overlapping defined portions are in contact with the liquid containing the second species while said exposing to a liquid, reducing the amount of liquid, performing a measurement and increasing the amount of liquid are conducted.