Patent ID: 6855711

Claim:
A method for prevention of lipid peroxidation in the brain which comprises administering to an individual in need thereof an effective amount of a compound selected from the group consisting of: (a) a compound of formula I: wherein R 1 is H or hydrocarbyl; R 2 is a hydrophobic radical; R 3 is a radical selected from the group consisting of 3-(C 2 -C 6 )acyl-4-hydroxyphenyl, 3-hydroxyimino(C 2 -C 6 )alkyl-4-hydroxyphenyl, and COOZ, wherein Z is H, (C 1 -C 6 )alkyl, aryl or ar(C 1 -C 6 )alkyl; and n is an integer from 1 to 20; and (b) a compound of formula II: wherein R 4 is (C 1 -C 6 )acyl, nitro(C 1 -C 6 )alkyl, cyano(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl or —CH 2 NR 7 R 8 , wherein R 7 and R 8 , the same or different, is each H or (C 1 -C 6 )alkyl, or together with the N atom form a saturated or unsaturated 5-7 membered ring optionally containing a further heteroatom selected from the group consisting of N, O and S, the further N atom in such saturated 5-7 membered ring being optionally substituted by (C 1 -C 6 )-alkyl, (C 1 -C 6 )-acyl, hydroxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl, and 8-hydroxyquinolin-5-yl-(C 1 -C 6 )alkyl, and either R 5 is H and R 6 is (C 2 -C 6 )-acyl or hydroxyimino(C 2 -C 6 )alkyl, or R 5 and R 6 together with the phenyl ring form a quinoline, a 1,2,3,4-tetrahydroquinoline or a perhydroquinoline ring structure, or a pharmaceutically acceptable salt of a compound of formula I or II.