Patent ID: 7781418

Claim:
A pharmaceutical composition comprising (1R,6S)-2-azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, or a salt thereof, wherein the pharmaceutical composition is substantially free of (1S6R)-2-azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, and wherein the pharmaceutical composition is characterized by having an enhanced inhibitory effect on farnesyl pyrophosphate synthase compared to the inhibitory effect of racemic 2-azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid or (1S,6R)-2-azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid substantially free of(1R,6S)-2-azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid.