Patent ID: 7452891

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein m is 1; n is 1; X 1 is N; X 2 is N—R 5 ; X 3 is O or N—R 6 ; X 4 is NH, N—R 7 or N, and when X 4 is N, R 2 and X 4 can join together to form a heterocycloalkyl group wherein said heterocycloalkyl group is piperidine, pyrrolidine, morpholine, piperazine, thiomorpholine, where the N of X 4 is the heteroatom of said heterocycloalkyl group, wherein said heterocycloalkyl group can be optionally substituted with one or more alkyl, aryl, aralkyl, or cycloalkylalkyl; Ar is an arylene group; R is R 4 -phenyl, R 4 -pyridyl, R 4 -pyridyl-N-oxide, or R 4 -pyrimidyl; R 1 is hydrogen or (C 1 -C 3 )alkyl; R 2 is R 8 -phenyl; R 3 is hydrogen, OH, —O(C 1 -C 3 )alkyl, or non-substituted or halosubstituted (C 1 -C 3 )alkyl; R 4 and R 8 maybe the same or different, may number 0 to 3, each being independently selected from the group consisting of hydrogen, —(C 1 -C 6 )alkyl, —(C 3 -C 7 )cycloalkyl, halo, —CN, (C 1 -C 6 )alkoxy, —CF 3 , —OCF 3 , —CONH 2 , —CONH(C 1 -C 6 )alkyl, —CON(C 1 -C 6 )alkyl (C 1 -C 6 )alkyl, —NH 2 , —NHC(O)(C 1 -C 6 )alkyl, —NHC(O)NH(C 1 -C 6 )alkyl, —NHC(O)N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), —NHSO 2 (C 1 -C 6 )alkyl, —S(C 1 -C 6 )alkyl, —SO(C 1 -C 6 )alkyl, —SO 2 (C 1 -C 6 )alkyl, —SO 2 NH(C 1 -C 6 )alkyl, —O(C 1 -C 3 )alkyleneO—, and NO 2 or two adjacent R 4 or two adjacent R 8 groups together may form a methylenedioxy, propylenedioxy or ethylenedioxy group; R 5 is hydrogen, nonsubstituted or halosubstituted —(C 1 -C 6 )alkyl, or nonsubstituted or halosubstituted (C 3 -C 7 )cycloalkyl; R 6 and R 7 may be the same or different, each being independently selected from hydrogen, nonsubstituted or halosubstituted (C 1 -C 3 )alkyl; or R 6 and R 7 can be joined together to form an imidazolone ring.