Patent ID: 8298581

Claim:
A controlled release pharmaceutical composition for oral use in the form of a coated matrix composition, the matrix composition comprising i) a mixture of a first polymer and a second polymer that have plasticizing properties and which have melting points or melting intervals of a temperature of at the most 200° C., the first polymer being selected from the group consisting of polyethylene glycols and polyethylene oxides having a molecular weight of at least about 20,000 in crystalline and/or amorphous form, or a mixture such polymers, and the second polymer being selected from poloxamers having an HLB value of at least 18, ii) a therapeutically, prophylactically and/or diagnostically active substance, wherein the concentration of the second polymer in the matrix composition is from about 5 to about 90% w/w, the matrix composition being provided with a coating having at least one opening exposing at least one surface of said matrix, the coating comprising a first cellulose derivative which has thermoplastic properties and which is substantially insoluble in the aqueous medium in which the composition is to be used, and at least one of: a second cellulose derivative which is soluble or dispersible in water, a plasticizer, and a filler, wherein the active substance is released with a substantially zero order release.