Patent ID: 7671078

Claim:
A compound of formula I: wherein R 1 is a residue of formula (b) or (c) R 2 is —(CR 22 R 23 ) 1-3 — or —C(O)—; each of R 3 and R 8 is S; each of R 4 and R 5 , independently, is optionally R 25 -substituted C 3 -C 12 -cycloalkyl, C 1 -C 12 -alkyl or saturated C 8-12 -polycyclic residue; or optionally R 26 - and/or R 27 -substituted aryl, arylC 1-4 -alkyl or heteroaryl; R 6 is H; C 1 -C 6 -alkyl; C 3 -C 6 -cycloalkyl; or optionally R 26 - and/or R 27 -substituted aryl, arylC 1-4 -alkyl or heteroaryl; R 7 is CR 28 ; R 9 is a direct bond; each of R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , R 23 and R 28 , independently, is H; F; Cl; Br; C 1 -C 6 -alkyl; C 2 -C 6 -alkoxyalkyl; C 1 -C 6 -halogenoalkyl; C 3 -C 6 -cycloalkyl; optionally R 26 - and/or R 27 -substituted aryl or heteroaryl; CONR 29 R 30 ; COOR 29 ; CN; NO 2 ; or OR 31 ; each of R 29 and R 30 , independently, is H; C 1 -C 6 -alkyl; C 2 -C 6 -alkoxyalkyl; C 1 -C 6 -halogenoalkyl; C 3 -C 7 -cycloalkyl; or optionally R 26 - and/or R 27 -substituted aryl, arylC 1-4 -alkyl or heteroaryl; R 25 represents 1-to-4 substituents each, independently, H; F; Cl; Br; C 1 -C 6 -alkyl; C 2 -C 6 -alkoxyalkyl; C 1 -C 6 -halogenoalkyl; C 3 -C 6 -cycloalkyl; optionally R 26 - and/or R 27 -substituted aryl or heteroaryl; CONR 29 R 30 ; COOR 29 ; CN; NO 2 ; or OR 31 ; R 26 represents 1-to-4 substituents each, independently, selected from C 1 -C 6 -alkyl; C 1 -C 6 -hydroxyalkyl; C 2 -C 6 -alkoxyalkyl; C 1 -C 6 -halogenoalkyl; C 3 -C 6 -cycloalkyl; C 2 -C 6 -alkenyl; C 3 -C 6 -cycloalkenyl; C 2 -C 6 -alkynyl; aryl; heteroaryl; heteroaryl N-oxide; F; Cl; Br; I; OH; OR 4 ; CONH 2 ; CONHR 4 ; CONR 4 R 4 ; OC(O)R 4 ; OC(O)OR 4 ; OC(O)NHR 4 ; OC(O)NR 4 R 4 ; OSO 2 R 4 ; COOH; COOR 4 ; CF 3 ; CHF 2 ; CH 2 F; CN; NO 2 ; NH 2 ; NHR 4 ; NR 4 R 4 ; NHC(O)R 4 ; NR 4 C(O)R 4 ; NHC(O)NHR 4 ; NHC(O)NH 2 ; NR 4 C(O)NHR 4 ; NR 4 C(O)NR 4 R 4 ; NHC(O)OR 4 ; NR 4 C(O)OR 4 ; NHSO 2 R 4 ; N(SO 2 R 4 ) 2 ; NR 4 SO 2 R 4 ; SR 4 ; S(O)R 4 ; SO 2 R 4 ; Si(CH 3 ) 3 and B(OC(CH 3 ) 2 ) 2 ; R 27 represents two adjacent substituents which form an annulated 4-7-membered nonaromatic ring optionally containing up to two heteroatoms selected, independently, from N, O and S; R 31 is C 1 -C 6 -alkyl; C 3 -C 7 -cycloalkyl; optionally R 26 - and/or R 27 -substituted aryl, arylC 1-4 -alkyl or heteroaryl; or CF 3 ; or a pharmaceutically-acceptable salt thereof.