Patent ID: 8637636

Claim:
A peptide synthesis apparatus, comprising: at least one reaction chamber for synthesizing at least one target peptide; a plurality of aminoacylated tRNA (“aa-tRNA”) sources, each of the plurality of aa-tRNA sources including aa-tRNA; a plurality of fluid channels fluidly coupling at least a portion of the plurality of aa-tRNA sources to the reaction chamber; and a computing device coupled to the at least a portion of the plurality of aa-tRNA sources, the computing device including a computer readable medium storing computer executable instructions that when executed by the computing device direct the at least a portion of the plurality of aa-tRNA sources to sequentially flow the aa-tRNA therefrom one type of the aa-tRNA at a time according to a predetermined order into the at least one reaction chamber, in which incorporation of amino acids from at least some of the sequentially flowed aa-tRNA into the at least one target peptide is not guided by the standard genetic code.