Patent ID: 6861539

Claim:
Compound represented by the formula: or a pharmaceutically acceptable salt, or ester thereof, wherein R represents alkyl of 1-5 carbon atoms, alkenyl of 2-5 carbon atoms, alkynyl of 2-5 carbon atoms, hydroxyalkyl of 1-3 carbon atoms, alkoxyalkyl of 1-3 alkyl and 1-3 alkoxy carbon atoms, cyanoalkyl of 1-3 alkyl carbon atoms, imidazolylmethyl, —CH 2 CONH 2 , —CH 2 CH 2 CONH 2 , —CH 2 S(O) 2 NH 2 , —CH 2 SCH 3 , —CH 2 S(O)CH 3 , —CH 2 S(O) 2 CH 3 , —C(CH 3 ) 2 SCH 3 , —C(CH 3 ) 2 S(O)CH 3 or —C(CH 3 ) 2 S(O) 2 CH 3 ; R 3 represents alkyl of 1-5 carbon atoms, cycloalkyl of 5-8 ring members or cycloalkylmethyl of 3-6 ring members; R 10 represents hydrogen, alkyl, hydroxyalkyl or alkoxyalkyl, wherein alkyl and alkoxy are each 1-3 carbon atoms; R 11 represents alkyl of 1-5 carbon atoms, hydroxyalkyl of 1-4 carbon atoms, alkoxyalkyl of 1-4 alkyl carbon atoms, benzyl, imidazolylmethyl, —CH 2 CH 2 CONH 2 , —CH 2 CONH 2 , —CH 2 CH 2 SCH 3 or —CH 2 SCH 3 or sulfone or sulfoxide derivatives thereof; R 4 represents aryl benzo fused 5 to 6 ring member heteroaryl or benzo fused 5 to 6 ring member heterocyclo; or a radical of the formula wherein A and B each independently represent O, S, SO or SO 2 ; R 6 represents deuterium, alkyl of 1-5 carbon atoms, fluoro or chloro; R 7 represents hydrogen, deuterium, methyl, fluoro or chloro; or a radical of the formula wherein Z represents O, S or NH; and R 9 represents a radical of formula wherein Y represents O, S or NH; X represents a bond, O or NR 21 ; R 20 represents hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 2 to 5 carbon atoms, aralkyl of 1 to 5 alkyl carbon atoms, heteroaralkyl of 5 to 6 ring members and 1 to 5 alkyl carbon atoms, heterocycloalkyl of 5 to 6 ring members and 1 to 5 alkyl carbon atoms, aminoalkyl of 2 to 5 carbon atoms, N-mono-substituted or N,N-disubstituted aminoalkyl of 2 to 5 alkyl carbon atoms wherein said substituents are alkyl of 1 to 3 carbon atoms, aralkyl of 1 to 3 alkyl carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, alkoxycarbonylalkyl of 1 to 5 alkyl carbon atoms, cyanoalkyl of 1 to 5 carbon atoms or hydroxyalkyl of 2 to 5 carbon atoms; R 21 represents hydrogen or alkyl of 1 to 3 carbon atoms; or the radical of formula —NR 20 R 21 represents a 5 to 6 ring member heterocyclo; and R 22 represents alkyl of 1 to 3 carbon atoms or R 20 R 21 N-alkyl radical of 1 to 3 alkyl carbon atoms; and R 12 and R 13 each independently represent hydrogen, alkyl, aralkyl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, aryl or heteroaryl, wherein alkyl is 1-5 carbon atoms, cycloalkyl is 3-6 ring membered cycloalkyl optionally benzo fused, and heteroaryl is 5 to 6 ring membered heteroaryl optionally benzo fused.