Patent ID: 7488491

Claim:
A method for augmenting the immune response induced by an antigen in a mammal comprising conjointly administering to said mammal (i) a recombinant vector expressing an antigen selected from the group consisting of a protein, peptide, and glycoprotein, wherein said recombinant vector that expresses said antigen is selected from a recombinant adenovirus, a recombinant Sindbis virus, naked DNA, and naked RNA, and (ii) a pharmaceutical composition comprising an immunogenically effective amount of an adjuvant comprising a glycosylceramide of the general Formula 1: wherein R 1 , R 2 and R 5 represent H or a monosaccharide; R 3 and R 6 represent H or OH, respectively; R 4 represents H, OH or a monosaccharide; X denotes an integer from 1 to 23; R 7 represents any one of the following groups (a)-(g): (a) —(CH 2 ) 11 —CH 3 , (b) —(CH 2 ) 12 —CH 3 , (c) —(CH 2 ) 13 —CH 3 , (d) —(CH 2 ) 9 —CH(CH 3 ) 2 , (e) —(CH 2 ) 10 —CH(CH 3 ) 2 , (f) —(CH 2 ) 11 —CH(CH 3 ) 2 , and (g) —(CH 2 ) 11 —CH(CH 3 )—C 2 H 5 .