Patent ID: 8003647

Claim:
An (aza)indole derivative represented by the general formula (I): wherein T represents nitro, cyano or trifluoromethyl; ring J represents an aryl ring or a 6-membered heteroaryl ring; Q represents carboxy, lower alkoxycarbonyl, carbamoyl, mono(di)(lower alkyl)carbamoyl, sulfo, sulfamoyl or 5-tetrazolyl; Y represents hydroxy; X 1 , X 2 and X 3 independently represent CR 2 or N with the proviso that all of X 1 , X 2 and X 3 do not represent N at the same time, and when two or more R 2 exist, these R 2 are optionally the same or different from each other; and R 1 and R 2 independently represent a halogen atom, cyano, perfluoro(lower alkyl), -A A , -A-D-E-G or —N(-D-E-G) 2 with the proviso that two (-D-E-G) are optionally different from each other; in the formula, A A represents a hydrogen atom, hydroxy, thiol, —CHO, carboxy, —CONHR 3 , —NHR 3 , —N(R 3 )CHO, —N(R 3 )CONHR 4 or —SO 2 NHR 3 ; A represents a single bond, —O—, —S—, —CO—, —COO—, —CON(R 3 )—, —SO 2 —, —SO 2 N(R 3 )—, —N(R 3 )—, —N(R 3 )CO—, —N(R 3 )COO—, —N(R 3 )SO 2 — or —N(R 3 )CONR 4 — wherein R 3 and R 4 independently represent a hydrogen atom or lower alkyl; D represents optionally substituted lower alkylene, optionally substituted lower alkenylene, optionally substituted lower alkynylene, optionally substituted cycloalkylene, optionally substituted heterocycloalkylene, optionally substituted arylene or optionally substituted heteroarylene with the proviso that D is optionally further substituted by -E-G; E represents a single bond, —O—, —N(R 5 )—, —S—, —CO—, —COO—, —CON(R 5 )—, —SO 2 —, —SO 2 N(R 5 )—, —N(R 5 )CO—, —N(R 5 )COO—, —N(R 5 )SO 2 — or —N(R 5 )CON(R 6 )— with the proviso that R 5 and R 6 independently represent a hydrogen atom or lower alkyl; and G represents a hydrogen atom, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl(lower alkyl), optionally substituted heterocycloalkyl(lower alkyl), optionally substituted aryl(lower alkyl) or optionally substituted heteroaryl(lower alkyl) with the proviso that when G is a hydrogen atom, E is a single bond, —O—,—N(R 5 )—, —S—, —COO—, —CON(R 5 )—, —N(R 5 )CO—, —N(R 5 )CON(R 6 )— or —SO 2 N(R 5 )—, or R 5 and R 6 optionally bind together to form a ring, or with the proviso that when R 1 and R 2 or two R 2 bound to the neighboring atoms exist, these R 1 and R 2 or two R 2 optionally bind together to form a ring; respectively, or a prodrug thereof, or a pharmaceutically acceptable salt thereof.