Patent ID: 7214697

Claim:
A compound of formula I: wherein: R is C 3 –C 8 alkyl or (C 3 –C 7 cycloalkyl)C 1 –C 5 alk-di-yl; R 1 is H, CN, halo, C 1 –C 6 alkyl, C 1 –C 4 haloalkyl, CO 2 R 6 , CONR 6 R 6 , NR 6 COR 7 , NR 6 R 6 , OR 6 , SR 6 , SOR 7 , SO 2 R 7 or SO 2 NR 6 R 6 ; R 1a is H, halo or C 1 –C 6 alkyl; R 2 is H or C 1 –C 6 alkyl; R 3 and R 4 are independently H or C 1 –C 6 alkyl R 5 is hydrogen, optionally substituted phenyl or optionally substituted heterocycle; X is absent or is OCH 2 or SCH 2 ; X 1 is absent or C 1 –C 5 alk-di-yl; and X 2 is absent or is O, S, NH, NHSO 2 , SO 2 NH or CH 2 ; R 6 is independently at each occurrence H, C 1 –C 6 alkyl or phenyl; or when two R 6 moieties are connected to the same nitrogen atom, then said R 6 moieties may combine with the nitrogen to which they are attached to form a pyrollidinyl, piperidinyl or hexamethyleneimino ring; and R 7 is C 1 –C 6 alkyl or phenyl; or a pharmaceutical salt thereof.