Patent ID: 8575360

Claim:
A compound of formula I: wherein: R 1 is selected from —CN, —OCF 3 , —CF 3 , halogen, heteroaryl optionally substituted with halogen or C 1-3 alkyl and phenyl optionally substituted with halogen; R 2 is —Cl or —CF 3 ; R 3 is H or halogen; X is a group wherein R 4 is selected from: (A)-H; (B) C 1-3 alkyl optionally substituted with one or two groups selected from: a) C 3-6 cycloalkyl; b) —OR 9 ; c) —NR 9 R 10 ; d) —SOR 9 ; e) —SO 2 R 9 ; f) —C(O)NR 9 R 10 ; g) —C(O)OR 9 ; h) heteroaryl, optionally substituted with C 1-3 alkyl; i) heterocycyl, optionally substituted with C 1-3 alkyl; and j) phenyl optionally substituted with C 1-3 alkyl; (C) C 3-6 cycloalkyl; (D)heteroaryl; and (E) phenyl, optionally substituted with halogen, —OR 9 , —CN or —CF 3 ; R 5 is H or C 1-3 alkyl; or R 4 and R 5 , together with the carbon they are bonded to, form a saturated hydrocarbon ring with 3-7 carbon atoms and wherein one carbon atom in said hydrocarbon ring may be optionally replaced by —O—, —S—, —S(O)—, —SO 2 —, —NH—, —NCH 3 —, or —NC(O)CH 3 —; Y is a group wherein R 6 is H or C 1-3 alkyl; R 7 is H or C 1-3 alkyl; or R 6 and R 7 , together with the carbon they are bonded to, form a saturated hydrocarbon ring with 3-7 carbon atoms wherein one carbon atom in said hydrocarbon ring may be optionally replaced by —O—, —S—, —S(O) —, —SO 2 —, —NH—, —NCH 3 —, or —NC(O)CH 3 —; Z is aryl or heteroaryl; R 8 is selected from: (A) aryl optionally substituted with one or two groups selected from: (a) C 1-3 alkyl optionally substituted with —OR 9 , —NR 9 R 10 or —NR 9 SO 2 R 10 ; (b) C 3-7 cycloalkyl optionally substituted with —OR 9 or —NR 9 R 10 ; (a) —OR 9 ; (c) halogen; (d) —C(O)NR 9 R 10 ; (e) —SO 2 NR 9 R 10 ; (f) —NR 9 (CO)R 10 ; (g) —SO 2 R 9 ; (h) —NR 9 R 10 ; (i) —CN; (j) —C(O)OR 9 ; (k) —NR 9 SO 2 R 10 ; and (l) —C(O)R 9 ; and (B) heteroaryl optionally substituted with one to two groups selected from: (a) C 1-3 alkyl optionally substituted with —OR 9 , NR 9 R 10 or halogen; (b) C 3-7 cycloalkyl optionally substituted with —OR 9 , NR 9 R 10 ; (a) —OR 9 ; (c) halogen; (d) —C(O)NR 9 R 10 ; (e) —SO 2 NR 9 R 10 ; (f) —NR 9 (CO)R 10 ; (g) —SO 2 R 9 ; (h) —NR 9 R 10 ; and (i) —CN; R 9 is selected from H, C 1-5 alkyl or C 3-7 cycloalkyl; R 10 is selected from H, C 1-5 alkyl or C 3-7 cycloalkyl; or a pharmaceutically acceptable salt thereof.