Patent ID: 8354448

Claim:
A method of treating Type 2 diabetes in a mammal, comprising: administering to said mammal a therapeutically effective amount of the (−) stereoisomer of a compound of Formula I, wherein: R is a hydroxy group, a benzyloxy, phenethyloxy, formamidoethoxy, acetamidoethoxy, acetamidopropoxy, benzamidoethoxy, benzamidopropoxy, carbamoylmethoxy, carbamoylethoxy, 2-(4-chlorophenoxy)ethoxy, 2-(4-chlorophenoxy)-2-methylpropoxy or a 2-carbamoylphenoxy group forming an ester linkage capable of being hydrolyzed in vivo to provide a compound of formula I wherein R is OH; each X is independently a halogen; or a pharmaceutically acceptable salt thereof, wherein the compound contains the (−) stereoisomer in an enantiomeric excess of at least 80%.