Patent ID: 8202990

Claim:
A process form making 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4] diazepin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Form A characterized by peaks at 24.89, 21.78, 20.87, 20.35, 18.70, 16.40, 15.75, or 9.14 degrees 2-theta: comprising crystallization of 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4] diazepin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide from a solvent selected from the group consisting of C 2-4 alkylnitrile, C 3-7 alkylacetate, C 1-6 alcohol, C 2-8 ether, C 3-7 alkanone, C 6-9 aromatic hydrocarbons, and C 3-5 N, N-dimethylcarboxamide.