Patent ID: 7329669

Claim:
A method for treating a sex-hormone related condition selected from the group of prostate cancer, benign prostatic hypertrophy, breast cancer, endometriosis and uterine fibroids in a subject in need thereof, comprising administering to the subject an effective amount of a compound having the following structure: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: R 1a and R 1b are the same or different and independently hydrogen, halogen, C, 1-4 alkyl, or alkoxy; R 2a and R 2b are the same or different and independently hydrogen, halogen, trifluoromethyl, cyano or —SO 2 CH 3 ; R 3 is hydrogen or methyl; R 4 is phenyl or C 3-7 alkyl; R 5 and R 6 are the same or different and independently hydrogen or C 1-4 alkyl; or R 5 and the nitrogen to which it is attached taken together with R 4 and the carbon to which it is attached form 1,2,3,4-tetrahydroisoquinoline or 2,3-dihydro-1H-isoindole; R 7 is —COOH or an acid isostere; and X is —O—(C 1-6 alkanediyl)- or —O—(C 1-6 alkanediyl)-O-(C 1-6 alkanediyl)- wherein each C 1-6 alkanediyl is optionally substituted with from 1 to 3 C 1-4 alkyl groups.