Patent ID: 7825154

Claim:
A method of inhibiting the activity of Botulinum neurotoxin A metalloprotease which comprises contacting Botulinum neurotoxin A metalloprotease with at least one compound having the following structural formula: wherein X 1 is S, O or NR 8 ; X 2 is CR 7 ; L is a linker which may be a direct bond or where Z is an optionally substituted alkyl, alkenyl, dialkenyl, trialkenyl, or aryl; and R 1 , R 2 , R 5 and R 7 are each independently hydrogen, amino, amine with stabilized carbocations, carboxyl, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryloxy, aryoxy, cycloalkoxy, heteroaryloxy, alkoxycarbonyl, alkylamino, carbamoyl, alkylaminocarbonyl, alkylsulfhydryl, alkylhydroxymate; and R 8 is hydrogen, OH, a halogen, or an optionally substituted alkyl.