Patent ID: 7635715

Claim:
A compound of Formula I: a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer; or a mixture of any of the foregoing, wherein: m is 0 to 4; n is 1 to 6; R 1 and R 2 are independently selected from halogen, CN, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl, or R 1 and R 2 can join to form a spirocyclic ring system that may be substituted with one or more substituents; X is selected from —NR a —, —O—, —S—, or —(CR b R c )— wherein R a is selected from H or lower alkyl; R 3 and R 4 are independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R 3 and R 4 can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring; R 5 is selected from OH, SH, NH 2 , lower alkyl, substituted lower alkyl, lower alkoxy, substituted lower alkoxy, or sulfanyl; R 6 is selected from H, OH, SH NH 2 , NHSO 2 R 8 , or sulfonyl; each R 7 , if present, is independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, NR d R e , C(O)OR 8 , OR 8 , SR 8 , SO 2 R 8 , CN, NO 2 , halo, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, alkoxycarbonyl, substituted alkoxycarbonyl, haloalkyl, perhaloalkyl, or —Y—R 9 , wherein: Y is selected from —N(R 10 )—Z— or —Z—N(R 10 )—; Z is selected from C(O), SO 2 , alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, or substituted alkynylene; R 8 is selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl; R 9 is selected from H, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; R 10 is selected from H, lower alkyl, or substituted lower alkyl; R b and R c are independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R b and R c can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring; and R d and R e are independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R d and R e can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring.