Patent ID: 7652135

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: A is —CH 2 —; B is A is —CH 2 —; R 1 is T-Ar; T is a valence bond; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or: two R groups on the same nitrogen, taken together with the nitrogen atom attached thereto, form a 5-7 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Q is —C(O)—; R 2 is selected from C(R)(Ar)R 3 , wherein: R and R 3 optionally form a 5-7 membered saturated or partially unsaturated ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each Ar is independently an optionally substituted ring selected from a 5-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R 3 is independently selected from Ar 1 , W—OR 5 , W—OC(O)R 5 , W—CONHR 5 , W—OC(O)NHR 5 , W—SR 5 , W—N(R 4 ) 2 , N(R)(W—Ar), N(R)C(O)W—N(R 4 ) 2 , or N(R)W—N(R 4 ) 2 , wherein: each W is independently a valence bond or a C 1-6 alkylidene chain; each Ar 1 is independently selected from an optionally substituted 5-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R 4 is independently selected from R, COR 5 , CO 2 R 5 , CON(R 5 ) 2 , SO 2 R 5 , SO 2 N(R 5 ) 2 , or Ar 1 ; and each R 5 is independently selected from R or Ar.