Patent ID: 8664411

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: X is selected from the group consisting of O and CH 2 ; R 1 is selected from the group consisting of: (1) -alkylene-S(O) 2 —(C 1 -C 6 )alkyl, (2) -alkylene-S(O) 2 —(C 1 -C 6 )haloalkyl; (3) -alkylene-S(O) 2 —R 6 , (4) -alkylene-S(O) 2 —R 8 , (5) -alkylene-S(O) 2 -substituted(C 1 -C 6 )alkyl, (6) -alkylene-(tetrahydrothiophene1,1-dioxide), (7) -alkenyl-S(O) 2 —(C 1 -C 6 )alkyl, and (8) -cycloalkyl-S(O) 2 —(C 1 -C 6 )alkyl; wherein said -alkylene-S(O) 2 -substituted(C 1 -C 6 )alkyl R 1 group is substituted with one or more substituents independently selected from the group consisting of: —OH, halo, —CN, —CF 3 , —O—(C 1 -C 6 )alkyl, and —O-(halo(C 1 -C 6 )alkyl); R 2 is selected from the group consisting of: H and alkyl; R 6 is selected from the group consisting of: (1) unsubstituted (C 6 -C 14 )aryl, (2) (C 6 -C 14 )aryl substituted with one or more L 1A groups, (3) unsubstituted (C 5 -C 14 )heteroaryl, (4) (C 5 -C 14 )heteroaryl substituted with one or more L 1A groups, (5) unsubstituted (C 5 -C 14 )heteroarylalkyl-, and (5) (C 5 -C 14 )heteroarylalkyl- substituted with one or more L 1A groups; R 8 is selected from the group consisting of unsubstituted (C 3 -C 10) cycloalkyl and (C 3 -C 10) cycloalkyl substituted with one or more L 3 groups; each L 3 is independently selected from the group consisting of: (1) —CN, (2) ═(O), (3) —CH 2 OH, (4) amino, (5) halo, (6) —CH 2 NH 2 , (7) —CH 2 NHalkyl, (8) —C(O)OH, (9) -alkylene-C(O)NH(C 1 to C 6 )alkyl, (10) -alkylene-C(O)N((C 1 to C 6 )alkyl) 2 wherein each alkyl is independently selected, (11) -alkylene-C(O)NH(C 1 to C 6 )haloalkyl, and (12) -alkylene-C(O)N((C 1 to C 6 )haloalkyl) 2 wherein each alkyl is independently selected); Ar is selected from the group consisting of: (1) unsubstituted aryl, (2) aryl substituted with one or more L 1A groups, (3) unsubstituted heteroaryl, and (4) substituted heteroaryl substituted with one or more L 1A groups; each L 1 is independently selected from the group consisting of: halogen, (C 1 -C 6 ) alkyl, —CN, —CF 3 , —O—(C 1 -C 6 )alkyl, —O-(halo(C 1 -C 6 )alkyl), —C(O)—O—(C 1 -C 6 )alkyl, -alkylene-OH, halo(C 1 -C 6 )alkyl, hydroxyalkoxy-, alkoxyalkoxy-, and —S(O) 2 (C 1 -C 6 )alkyl; each L 1A is independently selected from the group consisting of: halogen, alkyl, —CN, —CF 3 , —O—(C 1 -C 6 )alkyl, —O-(halo(C 1 -C 6 )alkyl), —C(O)—O—(C 1 -C 6 )alkyl, -alkylene-OH, halo(C 1 -C 6 )alkyl, hydroxyalkoxy-, alkoxyalkoxy-, and —S(O) 2 (C 1 -C 6 )alkyl; and n is 0, 1, 2 or 3.