Patent ID: 7642244

Claim:
A neuropeptide-2 receptor agonist of the formula (I): wherein: X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa), Y is H or an acyl moiety, Y′ is a poly(ethylene) glycol moiety, PEG m -SSA, PEG m -β-SBA, PEG m -SPA or PEG m -BTC, R 1 is Ile, Ala, (D) Ile, N-methyl Ile, Aib, 1-1 Aic, 2-2 Aic, Ach or Acp, R 2 is Lys, Ala, (D) Lys, NMelys, Nle or (Lys-Gly), R 3 is Arg, Ala, (D) Arg, N-methyl Arg, Phe, 3,4,5- Trifluoro Phe or 2,3,4,5,6- Pentafluoro Phe, R 4 is His, Ala, (D) His, N-methyl His, 4-MeOApc, 3-Pal or 4-Pal, R 5 is Tyr, Ala, (D) Tyr, N-methyl Tyr, Trp, Tic, Bip, Dip, (1)Nal, (2)Nal, 3,4,5-TrifluroPhe or 2,3,4,5,6-Pentafluoro Phe, R 6 is Leu, Ala, (D) Leu or N-methyl Leu, R 7 is Asn, Ala or (D) Asn, R 8 is Leu or Trp, R 9 is Val, Ala, (D) Val or N-methyl Val, R 10 is Thr, Ala or N-methyl Thr, R 11 is Arg, (D) Arg or N-methyl Arg, R 12 is Gln or Ala, R 13 is Arg, (D) Arg or N-methyl Arg, R 14 is Tyr, (D) Tyr, N-methyl Tyr, modified-Tyr, Phe, modified-Phe or Trp, and m is 1 to 60 KDa, or a pharmaceutically acceptable salt thereof.