Patent ID: 8273917

Claim:
A method for preparing (R)-Baclofen of formula (I), comprising the steps of: reacting p-chlorocinamic acid with a chiral auxiliary compound of formula II to form a compound of formula III; performing Michael addition of nitromethane to a compound of formula III to give a compound of formula IV via diastereomeric selection; performing hydrolysis of the compound of formula IV to obtain a compound of formula V and recover the chiral auxiliary compound of formula II; and reducing a nitro group of the compound of formula V to yield (R)-Baclofen of formula I, wherein R 1 and R 2 are independently a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an aryl group having 6 to 10 carbon atoms; R 3 is an alkyl group having 1 to 8 carbon atoms or an aryl group having 6 to 10 carbon atoms; and X is N, O or S.