Patent ID: 7132456

Claim:
A compound of formula I: or a pharmaceutically acceptable salt, solvate, enantiomer, mixture of diastereomers, or prodrug thereof; wherein Ar 1 is phenyl optionally substituted with one to five groups selected from C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, hydroxy, C 1 –C 8 alkoxy, C 1 –C 8 alkylaryl, phenyl, aryl, C 3 –C 8 cycloalkyl, C 1 –C 8 alkylcycloalkyl, cyano, —(CH 2 ) n NR 1 R 2 , C 1 –C 8 haloalkyl, halo, (CH 2 ) n COR 6 , (CH 2 ) n NR 5 SO 2 R 6 , —(CH 2 ) n C(O)NR 1 R 2 , and C 1 –C 8 alkylheterocyclic; L 1 is OCH 2 CH 2 SCH 2 or SCH 2 ; Ar 2 is phenyl optionally substituted with one to three substitutents selected from C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, hydroxy, C 1 –C 8 alkoxy, C 1 –C 8 alkylaryl, phenyl, aryl, C 3 –C 8 cycloalkyl, C 1 –C 8 alkylcycloalkyl, cyano, C 1 –C 8 haloalkyl, halo, (CH 2 ) n C(O)R 6 , (CH 2 ) n C(O)OR 6 , (CH 2 ) n NR 5 SO 2 R 6 , (CH 2 ) n C(O)NR 1 R 2 , and C 1 –C 8 alkylheterocyclic; Ar 3 is phenyl optionally substituted with one to three substitutents independently selected from halo, —NHR 5 , C 1 –C 8 haloalkyl, C 3 –C 8 cycloalkyl, C 1 –C 8 alkyl, hydroxy, alkoxy, (CH 2 ) n C(O)R 6 , (CH 2 ) n C(O)OR 6 , (CH 2 ) n NR 5 SO 2 R 6 , (CH 2 ) n C(O)NR 1 R 2 , phenyl, C 1 –C 8 alkylaryl, and aryl; provided that Ar 2 and Ar 3 or positional isomers thereof are linked by a bond; L 2 is CONHCH 2 CH 2 , CONHCH 2 CH 2 CH 2 or CONHCH 2 CH 2 CH 2 CH 2 ; Q is a group represented by —NR 1 R 2 ; wherein R 1 and R 2 are independently selected from hydrogen, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 3 –C 8 cycloalkane, C 1 –C 8 alkylaryl, —C(O)C 1 –C 8 alkyl, —C(O)OC 1 –C 8 alkyl, C 1 –C 8 alkylcycloalkane, (CH 2 ) n C(O)OR 5 , (CH 2 ) n C(O)R 5 , (CH 2 ) n C(O)NR 1 R 2 , and (CH 2 ) n NSO 2 R 5 ; and wherein R 1 and R 2 may combine together, and with the nitrogen atom to which they are attached or with 0, 1, or 2 atoms adjacent to the nitrogen atom to form a nitrogen containing heterocycle which may have substituents; R 5 is hydrogen, C 1 –C 8 alkyl, C 2 –C 8 alkenyl; and R 6 is a group independently selected from hydrogen, C 1 –C 8 alkyl, and C 3 –C 8 cycloalkyl; wherein m is an integer from 0 to 4; and n is an integer from 0 to 3.