Patent ID: 7696201

Claim:
A compound of formula Ia or a pharmaceutically acceptable salt thereof, wherein X is —NR 50 — or —O—, R 50 is independently hydrogen or optionally substituted C 1-6 aliphatic; Each R 1a is a group containing at least four carbon atoms and is independently, aliphatic, cycloaliphatic, heteroaliphatic or heterocycloaliphatic, optionally substituted with aliphatic, cycloaliphatic, heteroaliphatic or heterocycloaliphatic, acyl, alkoxycarbonyl, cycloalkoxycarbonyl, heterocycloalkoxycarbonyl or amido, wherein the alkoxycarbonyl can be further substituted with aliphatic; R 2 is —Z B R 5 , wherein each Z B is independently a bond or an optionally substituted branched or straight C 1-6 aliphatic chain wherein up to two carbon units of Z B are optionally and independently replaced by —CO—, —CS—, —CONR B —, —CONR B NR B —, —CO 2 —, —OCO—, —NR B CO 2 —, —O—, —NR B CONR B —, —OCONR B —, —NR B NR B —, —NR B CO—, —S—, —SO—, —SO 2 —, —NR B —, —SO 2 NR B —, —NR B SO 2 —, or —NR B SO 2 NR B —; Each R 5 is independently R B , halo, —OH, —NH 2 , —NO 2 , —CN, or —OCF 3 ; and Each R B is independently hydrogen, optionally substituted C 1-4 aliphatic, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or an optionally substituted heteroaryl; Each R 3 is independently hydrogen, halo, optionally substituted aliphatic, optionally substituted (aliphatic)oxy, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl; and n is 0-4, Provided that when R 1a is substituted aliphatic, R 1a is substituted with 1-3 of halo, cyano, nitro, hydroxy, —NH 2 , optionally substituted alkoxy, optionally substituted cycloaliphatic, or optionally substituted heterocycloaliphatic; when R 1a is aliphatic substituted with a monocyclic heterocycloaliphatic, the monocyclic heterocycloaliphatic is not substituted with aryl; and when R 1a is optionally substituted cycloaliphatic, R 1a is not substituted with a substituted monocyclic heterocycloaliphic.