Patent ID: 8334304

Claim:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof, wherein —R 1 —R 2 — is a bivalent radical of formula —O—CH 2 —CH 2 —CH 2 —O— (a-5), wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C 1-6 alkyl or hydroxy, R 3 is hydrogen, halo, C 1-6 alkyl or C 1-6 alkyloxy; R 4 is hydrogen, halo, C 1-6 alkyl; C 1-6 alkyl substituted with cyano, or C 1-6 alkyloxy; C 1-6 alkyloxy; cyano; amino or mono or di(C 1-6 alkyl)amino; R 5 is hydrogen or C 1-6 alkyl, and the —OR 5 radical is situated at the 3- or 4-position of the piperidine moiety; L is a radical of formula -Alk-R 6 (b-1), -Alk-X—R 7 (b-2), -Alk-Y—C(═O)—R 9 (b-3), -Alk-C(═O)—NH—C(═O)—R 11 (b-4), -Alk-C(═O)—NH—SO 2 —R 11 (b-5), -Alk-SO 2 —NH—C(═O)—R 11 (b-6), -Alk-SO 2 —NH—SO 2 —R 11 (b-7), wherein each Alk is C 1-12 alkanediyl; and R 6 is aminosulfonyl optionally substituted with C 1-4 alkyl, C 3-6 cycloalkyl or phenyl; R 7 is C 1-6 alkylsulfonyl; X is NR 8 ; said R 8 being C 1-6 alkyl; R 9 is C 1-6 alkylsulfonylamino; Y is a O, S, or NR 10 wherein R 10 is hydrogen or C 1-6 alkyl; and R 11 is C 1-6 alkyl or phenyl.