Patent ID: 7423045

Claim:
A compound having the structure of Formula I: wherein: R 1 and R 2 are independently optionally substituted lower alkyl, optionally substituted aryl, optionally substituted alkenyl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; or R 1 and R 2 when taken together with the carbon atom to which they are attached represent a 5 or 6 membered carbocyclic or heterocyclic ring; R 3 is hydrogen, hydroxyl, optionally substituted lower alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted lower alkoxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, cyano, halo, —SO 2 —NR 9 R 10 , or —C(O)R 11 , in which R 9 and R 10 are independently hydrogen, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, or may joint to form a 5 or 6 membered optionally substituted heterocyclic ring, and R 11 is —OH or optionally substituted lower alkoxy; R 6 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, C(O)R 12 , or —S(O) 2 R 13 , in which R 12 is optionally substituted lower alkyl, lower alkoxy or —NR 14 R 15 , in which R 13 , R 14 , and R 15 are independently hydrogen, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl, or R 14 and R 15 may join to form a 5 or 6 membered optionally substituted heterocyclic ring; R 20 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, —SR 14 , —C(S)R 14 , —C(S)NR 14 R 15 , —S(O) 2 R 13 , or —S(O) 2 NR 9 R 10 ; and X is oxygen, sulfur, —S(O)—, —S(O) 2 — or —NR 16 —, in which R 16 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl, —C(O)R 12 , or —S(O) 2 R 13 .