Patent ID: 8623867

Claim:
A compound having the structural formula: or a pharmaceutically acceptable salt thereof, wherein R 3 is H or alkyl; R 4 is H or alkyl; R 14 is 1 to 4 substituents independently selected from the group consisting of H, alkyl, halo, —CN, and haloalkyl; R 27 and R 28 are independently selected from alkyl; or R 27 and R 28 together with the nitrogen to which they are attached, form an unsubstituted 3-7 membered heterocycloalkyl ring, or a 3-7 membered heterocycloalkyl ring substituted by 1-3 substituents independently selected from the group consisting of alkyl, alkoxyalkyl, haloalkoxyalkyl, cycloalkyl, cycloalkylalkyl and cycloalkyl-alkoxyalkyl; R 8 is H, alkyl, cycloalkylalkyl-, heterocycloalkyl-, arylalkyl-, heterocycloalkylalkyl-, —N(R 15 )(R 16 ), —OR 17 , —C(O)R 18 , or —C(O)OR 17 ; R 12 is selected from the group consisting of H and alkyl; R 30 is H, alkyl, -cycloalkylalkyl-, heterocycloalkyl-, arylalkyl-, heterocycloalkylalkyl-, —N(R 15 )(R 16 ), —OR 17 , —C(O)R 18 , or —C(O)OR 17 ; R 15 is H or alkyl; R 16 is H or alkyl; or R 15 and R 16 , together with the nitrogen to which they are attached, form a heterocycloalkyl ring; R 17 is H, alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; R 18 is H, alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, alkenyl, alkynyl or —N(R 24 )(R 25 ); R 24 and R 25 are each independently selected from H and alkyl; and wherein each of the alkyl, cycloalkylalkyl-, heterocycloalkyl-, arylalkyl-, heterocycloalkylalkyl-groups in R 8 and R 30 are independently unsubstituted or substituted by 1 to 5 R 32 groups independently selected from the group consisting of halo, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, arylalkyl, —NO 2 , —CN, haloalkyl, haloalkoxy, —N(R 33 )(R 34 ), —NH(cycloalkyl), acyloxy, —OR 35 , —SR 35 , —C(O)R 36 , —C(O)OR 35 , —PO(OR 35 ) 2 , —NR 35 C(O)R 36 , —NR 35 C(O)OR 39 , —NR 35 S(O) 0-2 R 39 , and —S(O) 0-2 R 39 ; or two R 32 groups on the same ring carbon atom in cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl together form ═O; R 33 and R 34 are independently selected from the group consisting of H and alkyl; R 35 is H, alkyl, cycloalkyl, aryl, cycloalkylalkyl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; R 36 is H, alkyl, cycloalkyl, aryl, cycloakylalkyl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, alkenyl, alkynyl or —N(R 37 )(R 38 ); R 37 and R 38 are independently selected from the group consisting of H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heterocycloalkyl, arylalkyl, heterocycloalkylalkyl, alkenyl and alkynyl; or R 37 and R 38 together with nitrogen to which they are attached, form a 3-7 membered heterocycloalkyl ring; and R 39 is alkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, alkenyl or alkynyl.