Patent ID: 7557211

Claim:
A compound of formula (I), enantiomers, diastereomers, and salts, thereof wherein R 1 is selected from hydrogen, and C 1-3 alkyl; R 2 is hydrogen; R 5 is —NR 3 R 4 ; R 3 and R 4 are independently selected from (a) hydrogen, (b) alkyl; R 6 is aryl, which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d and Z 3d ; or —SR 7a , or —N(R 8a )C(O)R 7a ; R 7a is independently (a) hydrogen, or (b) alkyl, or aryl; R 8a is hydrogen, Z 1a-1e , Z 2a-2e , Z 3a-3e are optional substituents at each occurrence independently selected from —W 1 —V 1 ; —W 2 —V 2 ; —W 3 —V 3 ; —W 4 —V 4 ; —W 5 —V 5 ; where W 1-5 are independently (1) a bond, or (2) alkyl, cycloalkyl, aryl; or where V 1-5 are independently (1) H (2) alkyl; (3) —U 1 —O—Y 5 , (6) —U 1 —S(O) t Y 5 , where t is 2, (7) —U 1 -halo, (8) —U 1 -cyano, (10) —U 1 —NY 2 Y 3 , (11) —U 1 —N(Y 4 )—C(O)—Y 1 , (15) —U 1 —N(Y 4 )—C(O)O—Y 5 , (18) —U 1 —C(O)—NY 2 Y 3 , (24) oxo; Y 1 , Y 2 , Y 3 , Y 4 and Y 5 (1) are each independently hydrogen, alkyl, cycloalkyl, piperidinyl, pyrroldinyl, 5-oxo-pyrrolidinyl, 6-oxo-piperidinyl, furanyl, isoxazolyl, pyridinyl, pyrazinyl, pyridazinyl, thiadiazolyl, imidazolyl any of which may be optionally independently substituted as valence allows with one or more Z 4 , Z 5 and Z 6 ; or Z 4 , Z 5 , and Z 6 are optional substituents at each occurrence independently selected from (1) H (2) alkyl; (3) —U 1 —O—Y 5a , (6) —U 1 —S(O) t Y 5a , (7) —U 1 -halo, (8) —U 1 -cyano, (10) —U 1 —NY 2a Y 3a , (11) —U 1 —N(Y 4a )—C(O)—Y 1a , (24) oxo; Y 1a , Y 2a , Y 3a , Y 4a and Y 5a (1) are each independently hydrogen, alkyl; U 1 is independently (1) a single bond, (2) alkylene, (3) alkenylene, or (4) alkynylene.