Patent ID: 7807659

Claim:
A compound of the formula I: wherein: R 1 is hydrogen, CN, CHN 2 , R, or —CH 2 Y; R is an aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, an aralkyl group, a substituted aralkyl group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group; Y is an electronegative leaving group, —OR, —SR, —OC═O(R), or —OPO(R 3 )(R 4 ); R 3 and R 4 are independently R or OR; R 2 is CO 2 H, CH 2 CO 2 H, or optionally substituted esters, amides or isosteres thereof; A is C═O or SO 2 ; X 1 is oxygen, sulfur, —NH, or —CH 2 , wherein —NH is optionally substituted by an alkyl group, a cycloalkyl group, a (cycloalkyl)alkyl group, an amino acid N-terminal protecting group, or COR and —CH 2 is optionally substituted by fluorine, an alkyl group, a cycloalkyl group, a (cycloalkyl)alkyl group, an aralkyl group, an aryl group, an alkyloxy group, an alkylthioxy group, an aryloxy group, an arylthioxy group, an oxo group (i.e., ═O), or a NHCOR group; X 2 is oxygen, sulfur, —NH, or —CH 2 , wherein —NH is optionally substituted by an alkyl group, or an amino acid N-terminal protecting group and —CH 2 is optionally substituted by an alkyl group, an aryl group, an alkyloxy group, an alkylthioxy group, an aryloxy group, an arylthioxy group, or an oxo (i.e., ═O) group, a NHCOR group; X 1 and X 2 optionally form part of a phenyl ring that is fused to the adjoining ring Q; X 3 is CH 2 or X 2 and X 3 optionally form part of a phenyl ring that is fused to the adjoining ring Q, provided that when X 2 forms a ring with X 3 , then X 2 does not form a ring with X 1 ; any two hydrogens attached to adjacent positions in ring Q are optionally replaced by a double bond; and Z is an optionally substituted ring selected from the group consisting of a carbocyclic, an aryl, a saturated heterocycle, a partially saturated heterocycle, and a heteroaryl wherein the ring is connected to A at a ring carbon; or a pharmaceutically acceptable derivative thereof.