Patent ID: 7943140

Claim:
A water-soluble, self-adjuvanting immunogenic composition comprising 16 immunogens, each immunogen comprising: (a) a different HIV-1 Tat B cell epitope sequence selected from the group consisting of V-D-P-R-L-E-P-W-K-H-P-G-S, SEQ ID NO: 15 V-D-P-K-L-E-P-W-K-H-P-G-S, SEQ ID NO: 16 V-D-P-N-L-E-P-W-K-H-P-G-S, SEQ ID NO: 18 V-D-P-S-L-E-P-W-K-H-P-G-S, SEQ ID NO: 17 V-D-P-K-L-E-P-W-N-H-P-G-S, SEQ ID NO: 21 V-D-P-N-L-E-P-W-N-H-P-G-S, SEQ ID NO: 19 V-D-P-S-L-E-P-W-N-H-P-G-S, SEQ ID NO: 22 V-D-P-N-L-D-P-W-N-H-P-G-S, SEQ ID NO: 20 V-D-P-R-L-D-P-W-K-H-P-G-S, SEQ ID NO: 32 V-D-P-K-L-D-P-W-K-H-P-G-S, SEQ ID NO: 33 V-D-P-N-L-D-P-W-K-H-P-G-S, SEQ ID NO: 34 V-D-P-S-L-D-P-W-K-H-P-G-S, SEQ ID NO: 35 V-D-P-R-L-E-P-W-N-H-P-G-S, SEQ ID NO: 36 V-D-P-R-L-D-P-W-N-H-P-G-S, SEQ ID NO: 37 V-D-P-K-L-D-P-W-N-H-P-G-S, SEQ ID NO: 38 and V-D-P-S-L-D-P-W-N-H-P-G-S. SEQ ID NO: 39 (b) a universal T helper sequence; (c) a lipopeptide cap selected from the group consisting of a dipalmitoyl-S-glyceryl-cysteine, a N-acetyl (dipalmitoyl-S-glyceryl cysteine), and a tripalmitoyl-S-glyceryl cysteine; and (d) a sequence of charged polar amino acids.