Patent ID: 8889146

Claim:
An immunogenic composition comprising at least two F protein antigens of different paramyxoviruses selected from the group of: human metapneumovirus (hMPV), parainfluenza virus 3 (PIV-3), and respiratory syncytial virus (RSV), wherein the at least two paramyxovirus F protein antigens each comprise a recombinant F protein polypeptide comprising an F 2 domain and an F 1 domain of a paramyxovirus F protein polypeptide, wherein the F protein polypeptide of hMPV and PIV-3 comprise a deletion of a furin cleavage site and a heterologous coiled-coil trimerization domain and wherein the F protein polypeptide of RSV lacks a transmembrane domain and comprises a deletion of two furin cleavage sites, a deletion of pep27, and a heterologous coiled-coil trimerization domain.