Patent ID: 7019109

Claim:
A cyclic somatostatin (SRIF) analog peptide which selectively binds SRIF receptor SSTR1, which peptide has the amino acid sequence (cyclo 3-14) X 1 -X 2 -X 3 -Lys-Phe-X 7 -X 8 -X 9 -Thr-X 11 -Thr-X 13 -Cys wherein: X 1 is des-X 1 , Ala, D-Ala, Cbm, Biu, (lower alkyl)Cbm, L-Hor, an acyl group having up to 20 carbon atoms, lower alkyl or a conjugating/complexing agent; X 2 is Tyr, ITyr, D-Tyr, D-ITyr, Gly, or des-X 2 ; X 3 is Cys or D-Cys; X 7 is (A)Phe wherein A is H, Cl, F, Br, NO 2 , Me, or NH(Q), where Q is H, Cbm, or L-Hor; X 8 is a D-isomer amino acid having an aromatic side chain; X 9 is an aminomethyl Phe wherein the side chain is (C 2 to C 5 )alkylated and which is N α methylated; X 11 is Phe, Tyr or ITyr; and X 13 is Ser, N α MeSer or D-Ser.