Patent ID: 7863282

Claim:
A compound of formula Ia: or a pharmaceutically acceptable salt thereof, wherein: R 2 is â€”R, halogen, â€”CN, â€”NO 2 , â€”CO 2 R, -T-Ar, or -T-R; R 2â€² is R, or R 2 and R 2â€² are taken together to form a optionally substituted 5-7 membered, partially unsaturated or fully unsaturated ring having zero to two ring heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: each substitutable ring nitrogen of the ring formed by R 2 and R 2â€² is optionally substituted; each occurrence of R is independently hydrogen, an optionally substituted C 1-6 aliphatic group, or Ar; Z 1 is CR x ; Z 2 is CR y ; R x and R y are taken together to form an optionally substituted 6 membered partially unsaturated or fully unsaturated carbocyclic ring; R 1 is hydrogen or an optionally substituted C 1-6 aliphatic group; each Ar is independently an optionally substituted 3-6 membered heterocyclic ring having one or two heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a 5 or 6 membered aryl ring having zero to three heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: Ar is optionally fused to a five or six membered partially unsaturated, or fully unsaturated ring having zero to two heteroatoms independently selected from nitrogen, oxygen, or sulfur; T is a C 1-4 alkylidene chain wherein one methylene unit of T is optionally replaced by â€”Oâ€”, â€”Sâ€”, â€”C(O)â€”, â€”CO 2 â€”, â€”NRâ€”, â€”NRC(O)â€”, â€”NRC(O)NRâ€”, â€”C(O)C(O)â€”, â€”OC(O)NRâ€”, â€”NRCO 2 â€”, â€”SO 2 NRâ€”, â€”NRSO 2 â€”, or â€”NRSO 2 NRâ€”; Q is â€”N(Râ€²)â€”, â€”Sâ€”, â€”Oâ€”, â€”C(Râ€²) 2 â€”, or a valence bond, wherein each Râ€² is independently hydrogen or C 1-6 aliphatic; and Ring D is a 5 or 6 membered optionally substituted monocyclic aryl ring having zero to two heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an eight to ten membered partially unsaturated or fully unsaturated bicyclic ring having zero to four heteroatoms independently selected from nitrogen, oxygen, or sulfur.