Patent ID: 8828442

Claim:
A composition, comprising: (a) a spray-dried solid dispersion comprising a low-solubility drug, a concentration-enhancing polymer and a stabilizing polymer selected from the group consisting of cellulose acetate phthalate, methyl cellulose acetate phthalate, hydroxypropyl methyl cellulose acetate phthalate, cellulose acetate trimellitate, methyl cellulose acetate trimellitate, hydroxypropyl methyl cellulose acetate trimellitate, wherein the amount of drug in crystalline form, once dispersed in said solid dispersion, does not exceed 20%; and (b) wherein said concentration-enhancing polymer is selected from the group consisting of hydroxypropyl methyl cellulose acetate succinate, hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose succinate, hydroxypropyl methyl cellulose phthalate, hydroxypropylcellulose, methyl cellulose, hydroxyethyl cellulose, hydroxy ethyl cellulose acetate, hydroxyethyl ethyl cellulose, hydroxy ethyl methyl cellulose acetate succinate, hydroxyethyl methyl cellulose acetate phthalate, polyvinyl alcohol/polyvinyl acetate copolymers, polyethylene glycol, polyethylene glycol polypropylene glycol copolymers, polyvinyl pyrrolidone, polyethylene polyvinyl alcohol copolymers, carboxylic acid-functionalized polymethacrylates, and amine-functionalized polymethacrylates, and increases the maximum drug concentration in a use environment relative to a control composition comprising an equivalent quantity of undispersed drug wherein, when measured at 50% relative humidity, the glass-transition temperature (Tg) of said stabilizing polymer is greater than the Tg of said concentration-enhancing polymer, and wherein said drug, said stabilizing polymer, and said concentration-enhancing polymer are codispersed in said dispersion.