Patent ID: 8198304

Claim:
A compound of formula I: wherein: R 1 is selected from —C 1-6 alkyl, —C 2-6 alkenyl, —C 3-9 cycloalkyl, and thiophenyl; R 2 is selected from aryl and thiophenyl; R 3 is selected from H and —C 0-1 alkylene-OH, or R 3 forms a double bond with R 1 ; or —CR 1 R 2 R 3 together form a group of formula: where A is selected from a bond, —O—, —S—, —CH 2 —, —CH═CH—, —CH 2 CH 2 —, —NH—, and —N(CH 3 )—; and R 4 is selected from H, halo, —OH, —C 1-8 alkyl, and —C 1-8 alkoxy; X is selected from —O— and —O—CH 2 —; Y′ is —CH—, Y is a bond and Y″ is —(CH 2 ) 2 —, or Y is —CH 2 — and Y″ is —CH 2 —; R 5 is selected from fluoro and —C 1-4 alkyl; and a is 0 or an integer of from 1 to 3; R 6 and R 7 are independently selected from H and —C 1-4 alkyl, and further wherein one of R 6 or R 7 may be —NH 2 ; Z is selected from —C 1-3 alkylene-Q and —NH—C 0-1 alkylene-Q; Q is selected from —C 3-7 cycloalkyl, aryl, and heteroaryl; and Q is optionally substituted with 1-5 R 8 groups independently selected from halo, —C 1-4 -alkyl, —C 0-4 alkylene-OH, cyano, —C 0-2 alkylene-COOH, —C(O)O—C 1-4 alkyl, —O—C 1-4 -alkyl, —S—C 1-4 -alkyl, —CONR 8a R 8b , and —N + (O)O; R 8a and R 8b are independently selected from H and —C 1-4 alkyl; wherein R 1 and R 2 are optionally substituted with 1 to 5 R a groups independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —C 3-6 cycloalkyl, cyano, halo, —OR b , —C(O)OR b , —SR b , —S(O)R b , —S(O) 2 R b , —C(O)NR c R d , and —NR c R d ; each R b is independently selected from H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; each R c and R d is independently selected from H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; wherein each alkyl, alkenyl, alkynyl, alkylene, and cycloalkyl group in R a-d , R 4-8 , and Z, is optionally substituted with 1 to 5 fluoro atoms; wherein each cycloalkyl in R a-d is optionally substituted with 1 to 3 substituents independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, cyano, halo, —O(C 1-4 -alkyl), —S(C 1-4 alkyl), —S(O)(C 1-4 alkyl), —S(O) 2 (C 1-4 alkyl), —NH 2 , —NH(C 1-4 alkyl), and —N(C 1-4 alkyl) 2 , wherein each alkyl, alkenyl and alkynyl group is optionally substituted with 1 to 5 fluoro substituents; and the alkylene group in Z is optionally substituted with 1 or 2 substituents independently selected from —C 1-2 alkyl and —OH; or a pharmaceutically acceptable salt thereof.