Patent ID: 8299276

Claim:
A [c2] daisy chain macromer, comprising a binding site and a corresponding recognition moiety, the binding site presenting a secondary amine and the corresponding recognition moiety comprising a first polyether chain and a second polyether chain, the first polyether chain presenting a first olefin and the second polyether chain presenting a second olefin, the first and second polyether chains being configured to allow binding of the first olefin with the second olefin through a metathesis reaction; a backbone portion located between the binding site and the recognition moiety, wherein the backbone portion comprises structurally rigid functionalities configured to minimize intramolecular interactions between the binding site and the corresponding recognition moiety; and a cap portion adjacent to the binding site, the cap portion configured to constrain movements of the recognition moiety when coordinately bound to the binding site, the cap portion and the recognition moiety being located at opposite ends of the macromer, wherein the binding site and the recognition moiety are configured to allow a coordinate binding of the recognition moiety to the binding site with an association constant (K a ) equal to or greater than about 75 M −1 ; and wherein the cap portion, the binding site, the backbone and the recognition moiety are attached together to form a linear [c2]daisy chain macromer structure.