Patent ID: 8796299

Claim:
A method for treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of at least one compound of Formula I: or a pharmaceutically-acceptable salt thereof, wherein Ar 1 is phenyl; X 2 is —O—; R 1 and R 2 are each independently selected from the group consisting of H, C 1 -C 6 alkyl, hydroxy(C 1 -C 3 alkyl), C 3 -C 8 cycloalkyl, —CH 2 F, —CHF 2 and —CF 3 ; or R 1 and R 2 , together with the carbon atom to which they are both attached, form a C 3 to C 6 alkylene ring; or R 1 and R 2 , together with the carbon atom to which they are both attached, form a C═O group; R 3 is selected from the group consisting of H, C 1 -C 6 alkyl, hydroxy(C 1 -C 3 alkyl), C 3 -C 8 cycloalkyl, —CH 2 F, —CHF 2 and —CF 3 ; each R 6 is independently selected from the group consisting of H, C 1 -C 6 alkyl and —OH; each R 7 is independently selected from the group consisting of H and C 1 -C 6 alkyl; n 2 is 2; R 4 and R 5 , together with the carbon atom to which they are both attached, form a 5- or 6-membered heterocycloalkyl ring selected from the group consisting of: wherein said 5- or 6-membered heterocycloalkyl ring is optionally substituted with from 1 to 6 substitutents independently selected from the group consisting of R 30 and R 31 ; R 18 is H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, hydroxy(C 2 -C 6 )alkyl or —P(O)(OH) 2 ; R 30 and R 31 are each independently selected from the group consisting of H and C 1 -C 2 alkyl, or R 30 and R 31 , together with the carbon atom to which they are both attached, form ═O; R 32 and R 33 are each independently selected from the group consisting of H and C 1 -C 6 alkyl; or a, where the physiological disorder, symptom or disease is asthma, emesis, nausea, depression, anxiety, cough or migraine.