Patent ID: 8420820

Claim:
A compound of formula I wherein R 1 denotes H or A, R 2 denotes A, Hal, CN, (CH 2 ) n CONH(CH 2 ) p Ar, —C(OH)R 5 —Ar, —[C(R 5 ) 2 ] n —Ar, —[C(R 5 ) 2 ] n -Het, —[C(R 5 ) 2 ] n -cycloalkyl, —NR 5 A, —NR 5 Ar, NR 5 Het, —[C(R 5 ) 2 ] m N(R 5 ) 2 , 1-hydroxycyclopentan-1-yl or 1-hydroxycyclohexan-1-yl, R 3 denotes H, R 5 , —[C(R 5 ) 2 ] n —Ar, —[C(R 5 ) 2 ] n -Het, or —[C(R 5 ) 2 ] n -cycloalkyl, R 4 denotes H, Het-, Ar—, —R 5 , —OR 5 , —[C(R 6 ) 2 ] n C(O)N(R 6 ) 2 , CO-Het or O(CH 2 ) p Het 1 , R 5 denotes H, A or cycloalkyl, R 6 denotes H or A′, A′ denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are each optionally replaced by F, cycloalkyl denotes a cyclic alkyl having 3-7 C atoms, which is optionally substituted by alkyl having 1-6 C atoms, A denotes unbranched or branched alkyl having 1-10 C atoms, in which one or two CH and/or CH 2 groups are each optionally replaced by N, O, S atoms and/or by —CH═CH— groups and/or in addition 1-7 H atoms are each optionally replaced by F, X denotes NH, O, S or SO 2 , Ar denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR 5 , N(R 5 ) 2 , NO 2 , CN, COOR 5 , CON(R 5 ) 2 , NR 5 COA, NR 5 SO 2 A, COR 5 , SO 2 N(R 5 ) 2 and/or S(O) p A, Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, and/or O and/or S atoms which is unsubstituted or mono- or disubstituted by Hal, A, OR 5 , (CH 2 ) p N(R 5 ) 2 , NO 2 , CN, (CH 2 ) p COOR 5 , (CH 2 ) p CON(R 5 ) 2 , NR 5 COA, (CH 2 ) p Het 1 , (CH 2 ) p COHet 1 , NR 5 SO 2 A, COR 5 , SO 2 NR 5 and/or S(O) p A, Het 1 denotes a saturated heterocycle having 1 to 4 N, O, and or S atoms which is unsubstituted or mono- or disubstituted by A, S(O) p A and/or COA, Hal denotes F, Cl, Br or I, m denotes 1, 2, 3 or 4, n denotes 0, 1, 2, 3 or 4, p denotes 0, 1 or 2, or a pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.