Patent ID: 7253192

Claim:
A compound of the formula I wherein: X 1 is O or S; R 1 is hydrogen or C 1-7 -alkyl; R 2 is hydrogen or C 1-7 -alkyl, R 3 is hydrogen or C 1-7 -alkyl; R 4 and R 8 independently from each other are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 alkyl, fluoro-C 1-7 -alkoxy, cyano-C 1-7 -alkyl and cyano; R 5 , R 6 and R 7 independently from each other are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 -alkyl, fluoro-C 1-7 -alkoxy, cyano-C 1-7 -alkyl and cyano; and one of R 5 , R 6 and R 7 is wherein X 2 is selected from the group consisting of S, O, NR 9 , (CH 2 ) P NR 9 CO and (CH 2 ) P CONR 9 ; R 9 is selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl, hydroxy-C 2-7 -alkyl and C 1-7 -alkoxy-C 2-7 -alkyl; R 10 is selected from the group consisting of C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl and C 1-7 -alkoxy-C 1-7 -alkyl; R 11 is selected from the group consisting of hydrogen, C 1-7 -alkyl, and C 1-7 -alkoxy-C 1-7 -alkyl; or R 10 and R 11 together with the carbon atom they are attached to form a C 3-6 -cycloalkyl ring; m, o, p is 0, 1 or 2; n is 0, 1, 2 or 3; and the sum of m, n and o is 1 to 5; R 12 is unsubstituted phenyl, phenyl substituted with one to three groups selected from the group consisting of C 1-7 -alkyl, C 1-7 -alkoxy, halogen, fluoro-C 1-7 -alkyl, fluoro-C 1-7 -alkoxy and cyano, unsubstituted pyridyl or pyridyl substituted with one to three groups selected from the group consisting of C 1-7 -alkyl, C 1-7 -alkoxy, halogen, fluoro-C 1-7 -alkyl, fluoro-C 1-7 -alkoxy and cyano; and pharmaceutically acceptable salts or esters thereof.