Patent ID: 7601367

Claim:
A composition for delivery of siRNA to a mammalian cell comprising: said siRNA, a first amphipathic compound that is a cationic lipid, a second amphipathic compound that is a cationic lipid and a polycation, wherein the polycation is not a DNA-binding protein and is selected from the group consisting of: polyvinylamine, polyallylamine, polyethylenimine and ethoxylated polyethylenimine wherein said second amphipathic compound consists of an amphipathic compound having the structure: wherein R1 and R2 are selected from the group consisting of a C6 to C24 alkane, C6-C24 alkene, mono-substituted alkyl silane, di-substituted alkyl silane, tri-substituted alkyl silane, cycloalkyl, sterol, steroid, substituted lipid, acyl segment of a fatty acid, hydrophobic hormone, and hydrophobic hormone analog.