Patent ID: 8513185

Claim:
A peptide comprising an amino acid sequence consisting of R1-AA1-AA2-A1-A2-B1-B2-C1-D1-E1-F1-G1-G2-H1-H2-HH1-HH2-R2, wherein: R1 is absent or is selected from the group consisting of N-terminal sugar conjugate and N-terminal lipid conjugate; AA1 is absent or is selected from the group consisting of Arg, Arg-Arg, Arg-Arg-Arg and Arg-Arg-Arg-Arg; AA2 is absent or is selected from the group consisting of Lys, Lys-Lys, Lys-Lys-Lys and Lys-Lys-Lys-Lys; A1 is absent or is selected from the group consisting of Ser, Thr, Pro, Phe, Leu, Ala, Val, Ile, Met, Trp, a two amino acide peptide, a three amino acide peptide, a four amino acide peptide, a five amino acide peptide and a six amino acid peptide, said peptide consisting of Ser, Thr, Pro, Phe, Leu, Ala, Val, Ile, Met and Trp in any combination; A2 is absent or is a positively charged amino acid selected from the group comprising Arg, Lys and His; B1 is selected from the group consisting of Gln, Ser, Gly, Tyr, Cys, Thr, Asn and a two amino acid peptide, said peptide consisting of Gln, Ser, Gly, Tyr, Cys, Thr and Asn in any combination; B2 is absent or is a positively charged amino acid selected from the group comprising Arg, Lys and His; C1 is selected from the group consisting of Pro, Phe, Leu, Ala, Val, Ile, Met, Trp and a two amino acid peptide, said peptide consisting of Pro, Phe, Leu, Ala, Val, Ile, Met and Trp in any combination; D1 is selected from the group consisting of Gln, Ser, Gly, Tyr, Cys, Thr and Asn; E1 is a positively charged amino acid selected from the group comprising Arg, Lys and His; F1 is selected from the group consisting of Gln, Ser, Gly, Tyr, Cys, Thr and Asn; G1 is selected from the group consisting of Pro, Phe, Leu, Ala, Val, Ile, Met, Trp, a two amino acide peptide and a three amino acide peptide, said peptide consisting of Pro, Phe, Leu, Ala, Val, Ile, Met and Trp in any combination; G2 is absent or is a positively charged amino acid selected from the group comprising Arg, Lys and His; H1 is absent or is selected from the group consisting of Ser, Thr, Pro, Phe, Leu, Ala, Val, Ile, Met, Trp, a two amino acide peptide, a three amino acide peptide, a four amino acide peptide, a five amino acide peptide and a six amino acid peptide, said peptide consisting of Ser, Thr, Pro, Phe, Leu, Ala, Val, Ile, Met and Trp in any combination; H2 is absent or is a positively charged amino acid selected from the group comprising Arg, Lys and His; HH1 is absent or is selected from the group consisting of Arg, Arg-Arg, Arg-Arg-Arg and Arg-Arg-Arg-Arg; HH2 is absent or is selected from the group consisting of Lys, Lys-Lys, Lys-Lys-Lys and Lys-Lys-Lys-Lys; and R2 is absent or is C-terminal lipid conjugate.