Patent ID: 7304062

Claim:
A compound represented by the following structural Formula I: and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C 1 -C 8 alkyl, aryl-C 0-4 -alkyl, heteroaryl-C 0-4 -alkyl, C3-C6 cycloalkylaryl-C 0-2 -alkyl, and —CH 2 —C(O)—R17-R18, wherein R17 is O or NH and R18 is optionally substituted benzyl; (b) W is O; (c) R2 is H or a substituted or unsubstituted group selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 allyl, aryl-C 0-4 -alkyl, heteroaryl-C 0-4 -alkyl, sulfonamide, amide, OR10 and C 3 -C 6 cycloalkyl; (d) X is an optionally substituted C 2 C 5 alkylene linker; (e) Y is O, S, or NH; and (f) E is selected from the group consisting of A, C(R3)(R4)A, (CH 2 ) n COOR19 wherein the (CH 2 ) n COOR19 moiety is substituted or unsubstituted with from one to three substituents each independently selected from the group consisting of C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 1 -C 5 haloalkyl, C 1 -C 5 haloalkoxy, nitro, cyano, CHO, hydroxyl, C 1 -C 4 alkanoic acid phenyl, aryloxy, SO 2 R7, SR7, benzyloxy, alkylcarboxamido, and COOH, wherein R7 is alkyl or haloalkyl, wherein (i) n is 0, 1, 2 or 3, (ii) A is a moiety selected from the group consisting of carboxyl, C 1 -C 3 alkylnitrile, carboxamide, substituted or unsubstituted sulfonamide, substituted or unsubstituted acylsulfonamide and substituted or unsubstituted tetrazole; (iii) R3 is H, saturated or unsaturated C 1 -C 5 alkyl, C 1 -C 5 alkoxy, and (iv) R4 is H, halo, a substituted or unsubstituted group selected from C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 3 -C 6 cycloalkyl, aryl C 0 -C 4 alkyl and phenyl, or R3 and R4 are combined to form a C 3 -C 4 cycloalkyl; (v) R19 is selected from the group consisting of hydrogen, optionally substituted arylmethyl and optionally substituted C 1 -C 4 alkyl; (vi) R14 is selected from the group consisting of CF 3 , substituted or unsubstituted phenyl, substituted or unsubstituted aryl-C 0 -C 4 alkyl, and C 1 -C 6 alkyl; (g) R8 is independently selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkylenyl, and halo; (h) R9 is independently selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkylenyl, halo, substituted or unsubstituted aryl, substituted or unsubstituted aryl-C-C 4 alkyl, substituted or unsubstituted heteroaryl, C 1 -C 6 allyl, and OR10; and R10 is independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl.