Patent ID: 7247611

Claim:
A method of inhibiting PAI-1 binding to scuPA and tcuPA in a mammal, the method comprising administering to a mammal in need thereof a composition comprising a peptide consisting of the amino acid sequence X 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 , wherein: X 1 is a hydrogen or an amino-terminal blocking group; X 2 is an amino acid selected from the group consisting of D, E, H, K, and R; X 3 is an amino acid selected from the group consisting of D and E; X 4 is an amino acid selected from the group consisting of I, L, and V; X 5 is an amino acid selected from the group consisting of I, L, and V; X 6 is an amino acid selected from the group consisting of M; X 7 is an amino acid selected from the group consisting of D, E, H, K, and R; and X 8 is hydrogen or a carboxyl-terminal blocking group.