Patent ID: 7618650

Claim:
A combination comprising at least one short acting hypnotic agent selected from the group consisting of zolpidem, zopiclone, eszopiclone, zaleplon, ramelteon, triazolam, etizolam, brotizolam and indiplon, and a compound defined by formula I, an enantiomer, a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof: wherein: X═Y denotes either a single or double bond between X and Y; X is CR, N, or O; Y is CR, CHR, CO, or N; Z is NR; A, B and E are the same or different and independently from each other are CR; D is CH 2 ; Ar is substituted or unsubstituted phenyl or furan; each R is independently chosen from hydrogen, halogen, CN, or C 1-4 alkyl C 1-4 alkoxy, C 1-4 alkenyl, R 1 and R 2 are the same or different and selected independently of each other from substituted or unsubstituted phenyl, benzyl, benzoyl, pyrrolidinylmethyl, and diC 1-4 alkylaminoalkyl; or R 1 and R 2 taken together with the nitrogen atom to which they are attached form an unsubstituted or at least monosubstituted piperazine; and wherein the substituents are selected from the group consisting of substituted or unsubstituted phenyl, C 3-8 cycloalkyl, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkenyl, fluoroalkyl of the formula C n H x F y , and fluoroalkoxy of the formula OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1.