Patent ID: 8518959

Claim:
A compound having a structure of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from H, Z-Q-Z, —C 1-8 alkyl-N(R 2 )(R 4 ), —C 1-8 alkyl-OR 3 , 3- to 8-membered carbocyclic or heterocyclic, aryl, heteroaryl, and C 1-4 aralkyl; R 2 and R 4 are each independently for each occurrence selected from H, C 1-4 alkyl, C 1-4 aralkyl, aryl, and heteroaryl, provided that when both R 2 and R 4 are on the same N atom and not both H they are different; R 3 is selected from H, C 1-4 alkyl, aryl, and heteroaryl; W is selected from Q is selected from O and NR 2 ; and Z is independently for each occurrence selected from C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl, wherein each heterocyclic group is a 3 to 10 membered non-aromatic ring including one to four heteroatoms selected from nitrogen, oxygen, and sulfur; wherein each aryl is phenyl; wherein each heteroaryl is a 5 to 7 membered aromatic ring including one to four heteroatoms selected from nitrogen, oxygen, and sulfur; and wherein each heterocyclic, aryl, and heteroaryl group is optionally substituted by one or more moieties selected from the group consisting of halogen, hydroxyl, carboxyl, alkoxycarbonyl, formyl, acyl, thioester, thioacetate, thioformate, alkoxyl, phosphoryl, phosphate, phosphonate, phosphinate, amino, amido, amidino, imino, cyano, nitro, azido, sulfhydryl, alkylthio, sulfate, sulfonate, sulfamoyl, and sulfonamido.