Patent ID: 8865170

Claim:
An anti-human-CC-motif-receptor-7 (anti-human-CCR7) antibody capable of specifically binding to an extracellular domain of human CCR7, wherein the antibody comprises complementarity determining regions 1 to 3 (CDRs 1-3) of any one of the following (A1) to (A8): (A1) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 5, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 6, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 7, (A2) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 15, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 16, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 17, (A3) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 25, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 26, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 27, (A4) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 35, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 36, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 37, (A5) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 45, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 46, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 47, (A6) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 55, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 56, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 57, (A7) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 65, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 66, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 67, and (A8) comprising a heavy chain CDR1 containing an amino acid sequence represented by SEQ ID NO: 75, a heavy chain CDR2 containing an amino acid sequence represented by SEQ ID NO: 76, and a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 77, and wherein the antibody is capable of interfering with a CCR7-dependent intracellular signal transduction mechanism caused by CCR7 ligand stimulation without relying on complement-dependent cell lysis action or antibody-dependent cell-mediated cytotoxicity.