Patent ID: 7834047

Claim:
A compound having the formula: or pharmaceutically acceptable salts or stereoisomers thereof, wherein: R 1 is a member selected from the group consisting of —OH, (C 1 -C 8 )alkyl and (C 1 -C 8 )haloalkyl; R 2 and R 3 are members independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl and (C 3 -C 8 )cycloalkyl; N cyc is a nitrogen heterocycle having a formula selected from the group consisting of formula (a), formula (c) and formula (d): wherein: R 2a , R 2a′ and R 5a are each H; R 3a and R 4a are each members independently selected from the group consisting of H, halogen, —CN, —NO 2 , unsubstituted (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 5 -C 14 )heterocycloalkyl, heteroaryl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkyl, —C(O)R′, —C(O)OR′, —C(O)N(R′) 2 , —OR″, —OC(O)R′, —NR′C(O)OR″, —S(O)R″, —SO 2 R″, —SO 2 N(R′) 2 , —N(R′) 2 , and —NR′C(O)R′; and optionally two adjacent R 3a , R 4a and R 5a members are combined to form a benzene or pyridine ring, fused to the remainder of N cyc ; and within formula (a), at least one of R 2a , R 2a′ , R 3a , R 4a and R 5a is other than H; any fused benzene or pyridine ring portion of N cyc is optionally substituted with from one to four members selected from the group consisting of H, halogen, —CN, —NO 2 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 5 -C 14 )heterocycloalkyl, heteroaryl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR″, —OR′, —SR′, —OC(O)R′, —C(O)N(R′) 2 , —S(O)R″, —SO 2 R″, —SO 2 N(R′) 2 , —N(R′) 2 and —NR′C(O)R′; each occurrence of R′ is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 5 -C 14 )heterocycloalkyl, heteroaryl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkyl, or two R′ groups, when attached to the same nitrogen atom, can be combined with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl group; each occurrence of R″ is independently (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 5 -C 14 )heterocycloalkyl, heteroaryl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, heterocyclyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl or aryl(C 1 -C 6 )alkyl.