Patent ID: 7714131

Claim:
A method for preparing a compound of formula (I): wherein R 1 is a member selected from the group consisting of: each R 2 is a member independently selected from the group consisting of (C 1 -C 4 )alkyl, halo, (C 1 -C 4 )haloalkyl, amino, (C 1 -C 4 )aminoalkyl, amido, (C 1 -C 4 )amidoalkyl, (C 1 -C 4 )sulfonylalkyl, (C 1 -C 4 )sulfamylalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )heteroalkyl, carboxy and nitro; the subscript n is 1 when R 1 has the formula (a) or (b) and 2 when R 1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R 1 ; the method comprising: (a) contacting a compound of formula (II): with a carboxylic acid activating reagent selected from the group consisting of thionyl halides, anhydrides and thioester generating reagents; in a compatible solvent; (b) brominating the product of step (a) with bromine in a compatible solvent; (c) esterifying the product of step (b) with a chiral alcohol selected from the group consisting of: in a compatible solvent to stereoselectively produce a compound of formula (I).