Patent ID: 8229557

Claim:
A medical system, comprising: an electrode for delivering at least one pacing pulse to a pacing site of a patient's heart during a cardiac cycle; an energy delivery and sensing unit coupled to the electrode; a hemodynamic sensor; another sensor; a memory configured to store at least a threshold that distinguishes between acute responsiveness and non-responsiveness to cardiac resynchronization therapy (CRT) for a patient population, patient population data, and a fusion algorithm; and a controller coupled to the memory, the hemodynamic sensor, the another sensor, and the energy delivery and sensing unit, the controller configured to: measure systolic timing intervals of a plurality of different events of the cardiac cycle derived from a plurality of signals sensed during the cardiac cycle, at least one of the plurality of signals produced by the hemodynamic sensor and indicating a systolic timing interval of a mechanical cardiac event of the plurality of different events of the cardiac cycle, and at least another of the plurality of signals produced by the another sensor, implement the fusion algorithm to combine the measured systolic timing intervals of the plurality of different events of the cardiac cycle and the patient population data to compute an estimate of probability of acute responsiveness to cardiac resynchronization therapy CRT for the pacing site, compare the estimate to the threshold, and generate an output indication of acute responsiveness or non-responsiveness of the pacing site to CRT based on the comparison of the estimate to the threshold.