Patent ID: 7256254

Claim:
An immunomodulatory peptide construct with the formula P 1 −X−P 2 where P 1 is a peptide associated with autoimmune disease, allergy or asthma, or host-versus-graft rejection and which binds to an antigen receptor on a set or subset of T cells; P 2 is an immune modulating peptide which (i) causes a directed immune response by said set or subset of T cells to which the peptide P 1 is attached or bound or (ii) binds to a T cell receptor which causes said set or subset of T cells to which the peptide P 1 is bound to initiate, but not complete, an immune response causing said set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P 1 and P 2 wherein peptide P 2 is selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 50, SEQ ID NO: 18, SEQ ID NO: 21, SEQ ID NO: 24, and SEQ ID NO: 28 and SEQ ID NO: 51.