Patent ID: 8864821

Claim:
A stent capable of being imaged in vivo during asymptomatic stent thrombosis comprising: (a) a stent dimensioned for implantation within a blood vessel; and (b) a stent coating covering at least a portion of the stent and comprising an imaging probe activatable during asymptomatic stent thrombosis, wherein the activatable imaging probe comprises a fluorochrome attachment moiety and a plurality of near-infrared fluorochromes linked to the fluorochrome attachment moiety at fluorescence-quenching interaction-permissive positions separated by a fluorescence activation site selectively cleavable by activated Factor XII, activated Factor XI, activated Factor IX, activated Factor VIII, activated Factor Xa, activated Factor V, thrombin, activated Factor XIII, or activated Factor VII; wherein a first near-infrared fluorochrome quenches a second near-infrared fluorochrome and the probe is activatable by cleavage at the fluorescence activation site whereupon the first fluorochrome no longer quenches the second fluorochrome and the fluorochromes become detectable during asymptomatic stent thrombosis.