Patent ID: 7060728

Claim:
A compound of the following formula I: wherein: R 1 is CO 2 R, CONR 2 R 3 , CH 2 OR 4 , CH 2 NR 5 R 6 , CH 2 N 3 , CH 2 Hal, CH 2 NO 2 , CH 2 SR 20 , COSR 21 , or 2,3,4,5-tetrazol-1-yl, wherein: R is H or CO 2 R forms a pharmaceutically acceptable salt or a pharmaceutically acceptable ester; NR 2 R 3 and NR 5 R 6 are the same or different and comprise a free or functionally modified amino group, with the proviso that at most only one of R 2 and R 3 is OH or alkoxy and at most only one of R 5 and R 6 is OH or alkoxy; OR 4 comprises a free or functionally modified hydroxy group; Hal is F, Cl, Br, or I; SR 20 comprises a free or functionally modified thiol group; and R 21 is H or COSR 21 forms a pharmaceutically acceptable salt or a pharmaceutically acceptable thioester; A, B and D are the same or different and are C 1 –C 5 alkyl, C 2 –C 5 alkenyl, C 2 –C 5 alkynyl, or a C 3 –C 5 allenyl group; C is cyclopropyl; X is (CH 2 ) m or (CH 2 ) m O, wherein m is 1–6; and Y is a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, acyl, or a free or functionally modified hydroxy, amino, or thiol group; or X—Y is (CH 2 ) p Y 1 ; wherein p is 0–6; and wherein: W is CH 2 , O, S(O) q , NR 8 , CH 2 CH 2 , CH═CH, CH 2 O, CH 2 S(O) q , CH═N, or CH 2 NR 8 ; wherein q is 0–2, and R 8 is H, alkyl, or acyl; Z is H, alkyl, acyl, halo, trihalomethyl, or a free or functionally modified amino, thiol, or hydroxy group; and ---- is a single or double bond; or X—Y is cyclohexyl or n-C 5 H 11 .