Patent ID: 8143299

Claim:
A compound of Formula I: wherein Het is a substituted 1,2,4-triazole; Z 1 , Z 2 , and Z 3 are independently a bond or R 1 —X—R 2 , wherein X is NR 3 , O, S, SO, or SO 2 ; R 1 and R 2 are independently a bond or substituted or unsubstituted, saturated or unsaturated, straight-chained or branched lower alkylene; and R 3 is hydrogen, substituted or unsubstituted phenyl, or substituted or unsubstituted, saturated or unsaturated, straight-chained or branched lower alkyl; Ar 1 is substituted monocyclic aryl; Ar 2 is substituted or unsubstituted indolyl; R a is hydrogen or a substituted or unsubstituted monocyclic, aryl, or heteroaryl ring system of 5 or 6 ring atoms or a bicyclic aryl or heteroaryl ring system of 8 to 12 ring atoms, wherein each monocyclic ring may contain 0 to 3 heteroatoms, each bicyclic ring may contain 0 to 4 heteroatoms, and each heteroatom is independently selected from the group consisting of N, O, and S; and the substituents of Ar 1 , Ar 2 , and R a , when substituted, comprise one to three moieties independently selected from the group consisting of alkyl, alkenyl, alkynyl, phenyl, aralkyl, aralkenyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, aralkoxy, aryloxy, acyloxy, halo, haloalkyl, nitro, cyano, amino, mono- and dialkylamino, acylamino, carboxy, carboxyalkyl, carbalkoxy, carbaralkoxy, carbalkoxyalkyl, carbalkoxyalkenyl, aminoalkoxy, amido, mono-alkylamido , di-alkylamido, N,N-cycloaLkylamido, sulfonyl, mono-alkyl sulfonyl, di-alkyl sulfonyl, sulfamoyl, monoalkyl sulfamoyl, di-alkyl sulfamoyl, halophenyl, benzoyl, alkylthio and alkylsulfmyl; or a pharmaceutically acceptable salt thereof.