Patent ID: 7064126

Claim:
A compound of formula (I): wherein: R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 3-6 cycloalkyl which is optionally substituted by C 1-6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R 2 is C 1-6 alkyl; R 3 is a group CO—G or SO 2 —G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally substituted by up to 3 groups selected from hydroxyl and C 1-4 alkyl; Q is CR 5 R 6 where R 5 is hydrogen, C 1-6 alkyl or fluorine and R 6 is hydrogen, OH or fluorine, or R 5 and R 6 together form a ═O group, with the proviso that R 5 cannot be fluorine when R 6 is OH; R 4 is a 5- to 10-membered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by up to 4 groups independently selected from halogen, C 1-4 alkyl, (poly)halo-C 1-4 -alkyl, C 1-4 alkoxy, (poly)halo-C 1-4 -alkoxy, C 1-4 alkylsulphonyl, (poly)halo-C 1-4 -alkylsulphonyl, oxo, thioxo, cyano, hydroxymethyl, methylthio, —NR 7 R 8 , —CO—NR 7 R 8 , —SO 2 NR 7 R 8 , or a 5- to 6-membered aromatic ring system wherein up to 3 ring atoms may be heteroatoms independently selected from oxygen, sulphur and nitrogen, and which may itself be substituted by up to 4 groups selected from halogen, C 1-4 alkyl, (poly)halo-C 1-4 -alkyl, C 1-4 alkoxy, (poly)halo-C 1-4 -alkoxy, C 1-4 alkylsulphonyl, (poly)halo-C 1-4 -alkylsulphonyl, oxo, thioxo, cyano, hydroxymethyl, methylthio, —NR 7 R 8 , —CO—NR 7 R 8 , and —SO 2 —NR 7 R 8 ; R 7 and R 8 are independently hydrogen, or C 1-4 alkyl; or R 7 and R 8 together with the nitrogen atom to which they are attached may form a 5 to 7 membered saturated heterocyclic ring, and pharmaceutically acceptable salts and solvates thereof.