Patent ID: 7513903

Claim:
A method of reducing mammal vessel resistance and increasing blood supply and perfusion to an ischemia tissue, area, or organ with a cultured vessel in situ, comprising: selecting a narrow artery or arteriole which is responsible to a local ischemia tissue, area, or organ, selecting a vein or venule that is capable of drawing blood from said ischemia area and can be spared from vein blood return, multiple vein lateral system, or volume conserve vein system, using a microsurgery device to make a hole or a flap on opposite lateral walls or wall complex of said artery or arteriole and said vein or venule, wherein said hole or flap having equivalent dimensions of approximately 10 microns-1 mm in plane and 1-600 microns in depth, connecting the artery or arteriole to the vein or venule so that at least 20% by volume blood in the artery or arteriole will be lead into the vein network while resistance adjustment of the vessel is remained but total resistance is reduced, wherein said connection is configured to allow blood flow through the lumen created between two openings in said vein or venule and artery or arteriole, and wherein said connection comprises an extravascular wrapping configured to provide extravascular support and promote endothelial cell growth over the interior surface of the connection between vessels, wherein the process is performed on cultured vessels in situ.