Patent ID: 8546588

Claim:
A compound of formula (I-i), (I-v), or (I-xi): or a pharmaceutically acceptable salt thereof; wherein: each occurrence of R 1 is independently hydrogen, halogen, C 1-4 alkyl, C 1-3 fluoroalkyl, —O—C 1-3 alkyl, —O—C 1-3 fluoroalkyl, cyano, hydroxy, —NHC(O)C 1-3 alkyl, —C(O)NHC 1-3 alkyl, —NHC(O)NHC 1-3 alkyl, or —NHS(O) 2 C 1-3 alkyl; R 2 is C 1-6 aliphatic, C 1-6 fluoroaliphatic, or unsubstituted or substituted 6-10-membered aryl; R 4b is hydrogen, or C 1-4 aliphatic; G is —R 3 , —V 1 —R 3 , —V 1 -L 1 -R 3 , -L 2 -V 1 —R 3 , -L 2 -V 2 —R 3 , or -L 1 -R 3 , L 1 is an unsubstituted or substituted C 1-3 alkylene chain; L 2 is an unsubstituted or substituted C 2-3 alkylene chain; V 1 is —C(O)—, —C(O)—CR A ═CR A —, —C(O)—N(R 4a )—, —C(O)—O—, or —S(O) 2 —; V 2 is —C(S)—, —N(R 4a )—, —N(R 4a )—C(O)—, —SO 2 —N(R 4a )—, —N(R 4a )—SO 2 —, —O—, —S—, —S(O)—, —N(R 4a )—C(O)—N(R 4a )—, —N(R 4a )—C(O)—O—, —O—C(O)—N(R 4a )—, or —N(R 4a )—SO 2 —N(R 4a )—; R 3 is unsubstituted or substituted C 1-6 aliphatic, unsubstituted or substituted 3-10-membered cycloaliphatic, unsubstituted or substituted 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, unsubstituted or substituted 6-10-membered aryl, or unsubstituted or substituted 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each occurrence of R A is independently hydrogen, fluoro, or unsubstituted or substituted C 1-4 aliphatic; and each occurrence of R 4a is independently hydrogen, or unsubstituted or substituted C 1-4 aliphatic.