Patent ID: 8889851

Claim:
A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor wherein the cleavable adaptor is represented by —C a —C b —, wherein C a is connected to X and is a direct bond, hydrocarbyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, a nucleoside, each of which is optionally substituted with one to two substituents selected from halo, hydroxyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkyl, amino or alklyamino; C b is a direct bond, a silanyl group, a trityl group, or a vicinyl alcohol group; L is a hydrocarbyl chain which may be optionally substituted with one to four substituent groups independently selected from the group consisting of 5-to 9-membered heteroaryl, 4- to 9-membered heterocyclyl, amino, ether, carboxyl, carbamoyl, (C 6 -C 12 )aryl, —O—R″, —O—CO—R″, —NR′—R″, —NR′—CO—R″, —CO—NR′—R″, —CO—R″, —CN, halogen, or a combination thereof, wherein R′ and R″ are independently H or (C 1 -C 6 )hydrocarbyl; or L is a hydrocarbyl chain interspersed with other atoms, as represented by —(CHR′) a —W b —(CHR′) c —V d —(CHR′) c —, wherein W and V are independently —O—, —S—, or —NR′—; R′ is H or (C 1 -C 6 )alkyl; and a, b, c, d, and e are independently an integer from 0 to 10; and Y is a linkage functional group selected from —O—, —S—, —NR′—, —NH—CO—O—, —O—CO—NH—, or —NH—CO—NH—, wherein R′ is hydrogen or (C 1 -C 6 )hydrocarbyl.