Patent ID: 7534805

Claim:
A compound of the formula in racemic, enantiomeric form or any combinations of these forms wherein: X is at least one H or halo; Y is —O— or —S—; A is H or (C 1 -C 6 )alkyl; Z is selected from the group consisting of: (C 1 -C 6 )alkyl optionally substituted by at least one halo; aryl optionally substituted by at least one member selected from the group consisting of: halo, nitro, cyano, hydroxy, (C 1 -C 6 )alkyl optionally substituted by at least one halo, —(CH 2 ) n —NR 3 R 4 , (C 1 -C 6 )alkyl-sulfonyl, (C 1 -C 6 )alkyl-thio, (C 1 -C 6 )alkoxy optionally substituted by at least one halo, (C 1 -C 6 )alkoxy-carbonyl, phosphate, sulfate, glycoside and —NH—C(O)—CH(R A )—NR 5 R 6 ; aryl-(C 1 -C 6 )alkyl; heteroaryl; Z 1 -Z′ 1 ; —NR N —C(O)-Z′ 2 and -Z 2 -Z′ 2 ; Z 1 is selected from the group consisting of —O—, —C(O)—O—, —NR N —C(O)— and —C(O)—NR N —; Z′ 1 is selected from the group consisting of (C 1 -C 10 )alkyl; aryl-(C 1 -C 6 )alkyl, the aryl of which is optionally substituted by at least one halo; and (C 1 -C 6 )alkyl substituted by at least one member selected from the group consisting of halo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio and —NR 1 R 2 ; R 1 and R 2 are, independently, H or (C 1 -C 6 )alkyl, or form together with the nitrogen atom to which they are attached, a heterocycloalkyl optionally substituted by (C 1 -C 6 )alkyl; Z 2 is selected from the group consisting from —O—, —S—, —SO 2 —, —C(O)—, —C(O)—NR N — and —NR N —; Z′ 2 is an aryl or heteroaryl, the aryl and heteroaryl being optionally substituted by at least one member selected from the group consisting of: halo, nitro, cyano, hydroxy, (C 1 -C 6 )alkyl optionally substituted by at least one halo, (C 1 -C 6 )alkyl-thio, (C 1 -C 6 )alkyl-sulfonyl, (C 1 -C 6 )alkoxy optionally substituted by at least one halo, aryl-alkoxy, (C 1 -C 6 )alkoxy-carbonyl, phosphate, sulfate, glycoside, —(CH 2 ) n —NR 3 R 4 and —NH—C(O)—CH(R A )—NR 5 R 6 ; R 3 and R 4 are, independently, selected from the group consisting of H or (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-carbonyl and (C 1 -C 6 )alkyl-sulfonyl, or R 3 and R 4 form together with the nitrogen atom to which they are attached, a heteroaryl or a heterocycloalkyl optionally substituted by (C 1 -C 6 )alkyl; R 5 and R 6 are, independently, H or (C 1 -C 6 )alkyl; R A is the residue of an amino acid of the formula NH 2 —CH(R A )—C(O)—OH; R N is hydrogen or (C 1 -C 6 )alkyl; n is an integer from 0 to 3; or a pharmaceutically acceptable salt thereof except compounds in which A is hydrogen and Z is -3-CF 3 .