Patent ID: 7060438

Claim:
A method for analyzing a patient's genetic predisposition to rheumatoid arthritis, said method comprising: (1) placing a liquid sample containing at least one type of amplicon, derived from the amplification of at least one polymorphic region of the HLA-DR locus of nucleic acid from said patient, in the presence of probes including: one or more specific “low-resolution” typing probe(s) having the ability to hybridize with the DRB 1*gr04 group of alleles, one or more specific “high-resolution” subtyping probe(s) associated with genetic susceptibility to rheumatoid arthritis and having the ability to hybridize with the following alleles: DRB1*0101, DRB1*gr0401, DRB1*gr0404, DRB1*gr0405, DRB1*gr0408 and DRB1*gr1402, and one or more specific “high-resolution” subtyping probe(s) associated with genetic resistance to rheumatoid arthritis and having the ability to hybridize with the following alleles: DRB1*gr0402, DRB1*gr0403, DRB1*gr0406 and DRB1*gr0407, wherein the high resolution subtyping probes make it possible to distinguish between allele(s) associated with susceptibility and allele(s) associated with resistance, to rheumatoid arthritis, according to whether or not they hybridize; and (2) determining the hybridization pattern between said sample and said probes to analyze the patient's genetic predisposition to rheumatoid arthritis.