Patent ID: 8742127

Claim:
A method for synthesizing a 6-halo-3-aryl-pyridine compound comprising: reacting a 2,5-dihalopyridine derivative represented by the following general formula (I): wherein, X 1 represents a chloro atom and X 2 represents a bromo atom; R 1 , R 2 and R 3 each represent a substituent independently selected from the group consisting of a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group and an optionally substituted aryl group; provided that in the alternative R 1 and R 2 may also be selected to form an optionally substituted ring together with the carbon atoms to which they are connected, with a magnesiation reagent to form the product of a magnesiation reaction comprising a 2-halo-5-pyridyl magnesium species; and reacting the magnesiation reaction product in the presence of a palladium compound, with a halogenoaryl derivative represented by the following general formula (II): wherein, X 3 represents a halogen atom; Y 1 represents a CH group or nitrogen atom; each R 4 represents a substituent independently selected from the group consisting of a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted alkoxy group, an optionally substituted cycloalkoxy group and an optionally substituted aryloxy group; and n represents an integer of 0 to 5; to obtain a 6-halo-3-arylpyridine derivative represented by the following general formula (III):