Patent ID: 7452981

Claim:
A humanized hB-F5 antibody derived from mouse monoclonal anti-CD4 antibody B-F5, wherein said hB-F5 antibody comprises V domains comprising: a) an H chain V domain comprising the sequence, EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGVISVK SENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSASYYRYDV GAWFAYWGQGTLVTVSS (SEQ ID NO: 1); and b) a L chain V domain comprising the sequence: DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSYIYWYQQKPGQPPKLLIYLAS ILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPWTFGQGTKVEIK (SEQ ID NO: 2), wherein said bB-F5 antibody is able to activate a subset of T CD4 + cells comprising CD4 + CD25 + cells.