Patent ID: 8404858

Claim:
A compound represented by formula (I-3): wherein E 1 is oxygen or optionally oxidized sulfur, R is hydrogen or C1-8 aliphatic hydrocarbon group, is α-configuration, is β-configuration, R 1 is hydrogen or C1-4 aliphatic hydrocarbon group, R 2 is hydrocarbon group which may have a substituent(s), with the proviso that R 2 is not C2-8 alkenyl which may have 1 to 5 halogen atom(s), excluding 2-[(2-{(1R,2R)-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(1R,2R)-2-[(1E,3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-5-oxocyclopentyl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(1R,2R)-2-[(1E)-4-hydroxy-4-methyl-1-nonenyl]-5-oxocyclopentyl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid, 2-[(2-{(1R,2R)-2-[(1E)-5-cyclohexyl-4-hydroxy-4-methyl-1-pentenyl]-5-oxocyclopentyl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid and 2-[(2-{(1R,2R)-2-[(1E)-5-cyclohexyl-4-hydroxy-4-methyl-1-pentenyl]-5-oxocyclopentyl}ethyl)sulfonyl]-1,3-thiazole-4-carboxylic acid, a salt thereof, an N-oxide thereof, an S-oxide thereof, or a cyclodextrin clathrate thereof.