Patent ID: 7563792

Claim:
A compound of formula XIII or a pharmaceutically acceptable salt thereof: wherein: R 1 is R x , substituted aryl, substituted alkyl, substituted fused cycloalkylaryl, substituted aralkyl, substituted cycloalkylarylalkyl, substituted heteroaryl, or substituted heteroarylalkyl, wherein the latter seven groups are substituted with at least one substituent selected from the group consisting of —CN, —OCF 3 , haloalkoxy, —SR 4 , —SCF 3 , haloalkylthio, —NR 5 R 6 , —SO 2 R 4 , —SO 2 NR 5 R 6a , heteroaryl, heterocyclyl or R 10 O—(CH 2 CH 2 O) j —, or combinations thereof; R x is substituted or unsubstituted: wherein each R 1a and R 1b are independently H, alkyl or fluoro; R 2 is branched or straight chain lower alkylidene, or lower alkylene; R 3a and R 3b are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, or taken together form a cycloalkyl group; each R 4 is independently hydrogen, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, aryl, substituted aryl, haloaryl, acyl, or heterocyclyl; each R 5 is independently hydrogen, alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkyl substituted aryl, or acyl; each R 6 is independently hydrogen, alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkyl substituted aryl, acyl, —SO 2 R 5 , or SO 2 NR 5 R 5 ; or R 5 and R 6 taken together with the atom to which they are attached form a heterocycle; each R 6a is independently hydrogen, alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkyl substituted aryl, acyl; or R 5 and R 6a taken together with the atom to which they are attached form a heterocycle; R 7 and R 8 are each, independently, hydrogen, alkyl, or acyl; D is —O—, —S—, or —N(R 9 )—; R 9 is hydrogen, alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkyl-substituted aryl, or acyl; R 10 is alkyl or haloalkyl; j is an integer from 1 to 20; and k is an integer from 1 to 4; provided that, in a compound of formula XIII, when R 3a and R 3b are each independently H, lower alkyl, or taken together form a cycloalkyl group and R 7 and R 8 are each hydrogen, then R 1 is R x or is substituted with at least one substituent from the group consisting of —OCF 3 , haloalkoxy, and R 10 O—(CH 2 CH 2 O) j —.