Patent ID: 8703738

Claim:
A method of treating a pathology consecutive to a modification in the homeostasis of the clotting system appearing during disorders of the cardiovascular and cerebrovascular system, comprising: administering to a patient in need thereof an effective amount of a biotinylated hexadecasaccharide of general formula I: in which: T represents a sequence T 1 or T 2 having the following formulae: Biot represents the group: R represents a (C 1 -C 6 )alkoxy radical, or an —OSO 3 − radical; R 1 represents a (C 1 -C 6 )alkoxy radical, or an —OSO 3 − radical; R 2 represents a (C 1 -C 6 )alkoxy radical or an —OSO 3 − radical; R 3 represents a (C 1 -C 6 )alkoxy radical, or an —OSO 3 − radical, or alternatively R 3 constitutes an —O—CH 2 — bridge, the —CH 2 — group being linked to the carbon atom bearing the carboxylic function on the same ring; and Pe represents a saccharide sequence having the following formula: and a pharmaceutically acceptable salt thereof; wherein the pathology is selected from: unstable angina, apoplexy, post-angioplasty restenosis, thromboembolic disorders associated with post-thrombolysis rethrombosis, infarction, dementia of ischaemic origin, peripheral arterial diseases, blood dialysis, auricular fibrillations, thrombosis during the use of vascular prostheses for aorto-coronary bypasses, thromboembolic pathologies of venous origin, pulmonary embolism, thrombotic complications observed following surgical operations, the development of tumours or the disruption of clotting, induced by bacterial, viral or enzymatic activators and thrombosis associated with endarterectomy or the insertion of endovascular prostheses.