Patent ID: 8207166

Claim:
A method of treating ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt stereoisomer, alkyl ester prodrug or phenyl(C 1 -C 5 ) alkyl ester prodrug thereof, wherein R 1 and R 2 are independently: (a) hydrogen; (b) (C 1 -C 5 )alkyl, optionally substituted with one or more of hydroxy or fluoro; or (c) halogen; A is phenyl, pyridine, or pyrimidine, optionally substituted with 1 or 2 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen; B is phenylene or naphthalene, optionally substituted with 1 to 4 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen; L is a bridging group which is —O—, —S—, or —CH 2 —; M is phenyl, pyridine or pyrimidine, optionally substituted with 1 to 3 substituents that are independently: (1) (C 1 -C 5 )alkyl; (2) (C 1 -C 5 )haloalkyl; (3) —O—R 3 ; (4) —NR 3 R 4 ; (5) halogen; (6) —C(O)NR 3 R 4 ; (7) cyano; (8) C(O)R 3 ; (9) —C≡C—R 3 or (10) nitro; n is zero or one and X is: (1) —O—; (2) —SO 2 —; (3) —NR 5 —; (4) —NR 5 —SO 2 —; (5) —N(SO 2 NR 7 R 8 )—; (6) —SO 2 —NR 5 —; (7) —NR 5 —C(O)—; (8) —C(O)—NR 5 —; (9) —C(O)— or (10) a single bond; Y is a linear or branched C 1 to C 6 alkyl fragment that is substituted with one or two Z groups, where each Z group is independently: (1) —OR 6 ; (2) —O—C(O)—R 6 ; (3) —NR 7 R 8 ; (4) —SO 2 —(C 1 -C 5 )alkyl; (5) —C(O)—O—R 6 ; (6) —NH—C(O)—R 6 ; (7) —C(O)—NR 7 R 8 or (8) a monocyclic, saturated, partially saturated, or aromatic heterocycle of 5-7 ring atoms containing at least one heteroatom selected from N, O, or S, that is optionally substituted with 1 to 3 substituents selected from (C 1 -C 5 )alkyl, (C 1 -C 5 )haloalkyl, hydroxy, amino, halogen, or oxo; with the proviso that when n is zero and X is —O—, —NR 3 —, or a single bond, then Z is not morpholine, piperidine, imidazole, or tetrazole; with the further proviso that when n is zero and X is a single bond, then Z is not —NR 7 R 8 ; R 3 , R 4 , R 5 and R 6 are each independently hydrogen or (C 1 -C 5 )alkyl optionally substituted with hydroxy; and R 7 and R 8 are independently hydrogen, or (C 1 -C 5 )alkyl optionally substituted with hydroxy; or the group —NR 7 R 8 forms a monocyclic saturated heterocyclic ring having 5 to 7 ring atoms optionally substituted on a carbon atom with hydroxy, where, in addition to the nitrogen atom in the group —NR 7 R 8 , zero to two of the other ring atoms is a hetero atom selected from N, O and S, and the remaining ring atoms are carbon.