Patent ID: 7034051

Claim:
A compound of formula I, wherein: R 1 is H or OH; R 2 is alkyl, aralkyl, or aryl; R 3 is alkyl or aralkyl; n and m are each independently the integer 1 or 2; Z is: Q is —O—, —CH 2 —, or —N(R 8 )—; J is —(CH 2 ) k —, —O—(CH 2 ) k−1 —, —(CH═CH—CH 2 )—, or —C(A)(B)CH 2 —, provided that when Z is Z 1 , k is the integer 1, and J is —O—(CH 2 ) k−1 —, then Q is —CH 2 —; k is the integer 1, 2, or 3; A is H and B is alkyl or H, or when taken together, A and B are ═O or ═CH 2 ; R 4 , R 5 , R 6 , and R 7 are each independently H, alkyl, halo, aryl, heteroaryl, —OH, —OR 9 , —SO 2 NR 10 R 11 , —(CH 2 ) r NR 12 R 13 , nitro, —CN, —CF 3 , —CF 2 CF 3 , —OCF 3 , —SR 9 , —SO 2 R 9 , —(CH 2 ) r C(═O)OR 9 , —(CH 2 ) r C(═O)NR 12 R 12a , or —(CH 2 ) r NHC(═O)NR 12 R 12a , provided that at least two of R 4 , R 5 , R 6 , and R 7 are other than —SO 2 NR 10 R 11 , —(CH 2 ) r NR 12 R 13 , —(CH 2 ) r C(═O)NR 12 R 12a , or —(CH 2 ) r NHC(═O)NR 12 R 12a ; R 8 is H, alkyl, —C(═O)R 9 , or —S(═O) 2 R 9 ; R 9 is alkyl or aralkyl; R 10 and R 11 are each independently H, alkyl, —(CH 2 ) p —OH, —(CH 2 ) p —OR 9 , cycloalkyl, cycloalkylalkyl, aryl, or taken together with the nitrogen atom to which they are attached, R 10 and R 11 form a 4–7 member heterocycle, optionally interrupted by one or more O, S or NR 8 groups; R 12 and R 12a are each independently H, alkyl, or aryl; R 13 is H, alkyl, —C(═O)R 14 , —S(═O) 2 R 14 , or —C(═O)OR 15 ; R 14 is alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, heteroaryl, heteroalkyl, heteroaralkyl, aryl, or aralkyl; R 15 is alkyl, cycloalkyl, alkylcycloalkyl, or aralkyl; r is the integer 0, 1, 2, 3, or 4; and p is the integer 2, 3, 4, 5, or 6; or a stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate, N-oxide or isomorphic crystalline form thereof.