Patent ID: 7989486

Claim:
A method of RSV viral load reduction in acute RSV airway infections comprising administering to a subject having an RSV airway infection a therapeutically effective amount of at least one DIM-related indole and at least one EGFR inhibitor sufficient to reduce the RSV load in said subject, wherein the DIM-related indole is selected from the group consisting of diindolylmethane, hydroxylated DIMs, methoxylated DIMs, 2-(indol-3-ylmethyl)-3,3′-diindolylmethane (LTR), hydroxylated LTRs, methoxylated LTRs, 1-(3-hydroxymethyl)-indolyl-3-indolymethane (HI-IM), 5,5′-dimethylDIM (5-Me-DIM), 2,2′-dimethylDIM (2-Me-DIM), 5,5′-dichloroDIM (5-Cl-DIM), imidazolelyl-3,3′-diindolylmethane, nitro-substituted imidazolelyl-3,3′-diindolylmethanes, 2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-[2,3-b]carbazole, 6-ethoxycarbonyloxy-5,7-dihydro-indolo-[2,3-b]carbazole and 2,10-dicarbethoxy-6-ethoxycarbonyloxy-5,7-dihydro-indolo-[2,3-b]carbazole, and 2,6-dicarbethoxy-3,3′-dimethyl-13,14-diindolylmethane.