Patent ID: 8232309

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein A is cyclopently R 1 is alkyl, cycloalkyl, alkenyl, halogen or haloalkyl; R 2 is hydrogen; R 3 is wherein R 4 is —C(O)—O—(CH 2 ) m R 5 , —C(O)(CH 2 ) n —R 6 , —(CH 2 ) r —R 7 , —C(O)R 8 , or —CH 2 (H)(OH)R 9 ; m is 1, 2, or 3; n is 1, 2 or 3; r is 1, 2 or 3; t is 0, 1, 2, 3 or 4; u is 0, 1, 2 or 3; R 5 is —O—P(O)(OR A )(OR A ), —P(O)(OR A )(OR A ), —OR A , —OC(O)(R A ), heterocycle, —C(O)OR A , —C(O)N(R B ) 2 , —C(O)(R A ), —NR A R B , or —N(R B )C(O)OR A , R 6 is —OC(O)(R A ), —OR A , —C(O)OR A , —NR A R B , —OP(O)(OR A )(OR A ), or —P(O)(OR A )(OR A ); R 7 is heterocycle, —OC(O)(R A ), —OC(O)(hydroxyalkyl), —OP(O)(OR A )(OR A ), or —P(O)(OR A )(OR A ), R 8 is heterocycle or N(R 8a )(R 8b ) wherein R 8a and R 8b are independently hydrogen or alkyl; R 9 is alkoxyalkyl, —C(O)OR A , -alkyl-N(R B )C(O)OR A , or heterocyclealkyl; R A is hydrogen, alkyl, alkoxyalkyl, aryl or arylalkyl; R B is hydrogen or alkyl; the heterocycle and the heterocycle moiety of the heterocyclealkyl, represented by R 5 , R 7 , R 8 , and R 9 , are each independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, haloalkyl, alkoxy, haloalkoxy, —C(O)OH, -alkyl-C(O)OH, and —N(Z A )(Z B ); Z A and Z B are each independently hydrogen, alkyl, —C(O)alkyl, formyl, aryl, or arylalkyl; and the aryl and the aryl moiety of the arylalkyl, represented by R A , Z A and Z B are each independently substituted with 0, 1, 2 or 3 substituents selected from the group consisting of alkyl, haloalkyl, alkoxy and haloalkoxy.