Patent ID: 7064117

Claim:
An 8-quinoline metal complex represented by Formula I wherein: X is halogen, and R is formula VI or VII wherein each T 1 , T 2 , and T 3 is independently OR 5 , NR 5 2 , NHCOR 5 , or O(CH 2 ) n NR 5 2 , where each R 5 independently represents H, a C 1-6 alkyl optionally substituted with one or more hydroxy or amino groups, and each n is independently 1, 2, 3, or 4, and • represents the point of attachment of R to Formula I defined above, and wherein ligands L1–L4 represent one of the tetradentate ligands IX or X wherein each R 1′ to R 4′ independently represents H, Me, CH 2 (CH 2 ) n SO 3 H, CH 2 (CH 2 ) n CO 2 H, CH 2 (CH 2 ) n OP(O)(OH) 2 , or CH 2 (CH 2 ) n NMe 2 , where each n is independently 1, 2, 3, or 4, each Z is independently —(CH 2 ) 2 — or —(CH 2 ) 3 —, and wherein the overall charge of the complex is neutral, positive, or negative and wherein in the case of a non-neutral complex F countercharge is selected from a range of physiologically acceptable counterions, including halide − , NO 3 − , NH 4 − , or Na + , and wherein q is the required number to neutralize the overall charge on the complex; or an enantiomer, a diastereomer or a physiologically functional salt thereof.