Patent ID: 7728157

Claim:
A method for preparing an aminosterol compound comprising the steps of: (a) reacting compound 2: in the presence of liquid ammonia and lithium to form compound 3: (b) reacting compound 3 in the presence of ethylene glycol to form compound 4: (c) reacting compound 4 in the presence of TEMPO and sodium hypochlorite to form compound 5: (d) reacting compound 5 with compound 6 to form compound 7: (e) reacting compound 7 in the presence of borane and (R)-MeCBS to form compound 8: (f) reacting compound 8 in the presence of H 2 and platinum on carbon to form compound 9: (g) reacting compound 9 in the presence of p-toluenesulfonic acid to form compound 10: (h) reacting compound 10 in the presence of sulfur trioxide pyridine complex to form compound 11: (i) reacting compound 11 with either spermine, followed by treatment with sodium borohydride to form compound 1436 or a pharmaceutically acceptable salt thereof: or with H 2 N(CH 2 ) 3 NH(CH 2 ) 4 N 3 , followed by sequential treatment with sodium borohydride and H 2 with RaNi to form squalamine or a pharmaceutically acceptable salt thereof