Patent ID: 8114987

Claim:
A method of preparing 2-deoxy-L-ribose of the following formula I, comprising the steps of: acylating and halogenating L-arabinose of the following formula (1) to prepare a 1-halo-2,3,4-triacyl compound of the following formula (5); allowing the compound of formula (5) to react with zinc in the presence of ethyl acetate and an organic base so as to prepare glycal of the following formula (6); treating the glycal of formula (6) with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose of formula (7); treating the compound of formula (7) with a base to prepare 1-alkoxy-2-deoxy-L-ribopyranose of the following formula (8); and hydrolyzing the compound of formula (8)in the presence of an acid catalyst: wherein R 1 is a C 1 -C 5 alkyl group, R 2 ′, R 3 ′, R 4 ′ are each benzoyl or toluyl, and Hal is halogen.