Patent ID: 7173053

Claim:
A compound of formula (I) or a pharmaceutical or veterinarily acceptable salt, hydrate or solvate thereof: wherein: Z represents a radical of formula â€”N(OH)CH(â•O); R 1 represents hydrogen, methyl or trifluoromethyl; R 2 represents methyl, ethyl, n-or iso-propyl, n- and iso-butyl, n-pentyl, iso-pentyl, 3-methyl-but-1-yl, n-hexyl, n-heptyl, n-acetyl, n-octyl, methylsulfanylethyl, ethylsulfanylmethyl, 2-methoxyethyl, 2-ethoxyethyl, 2-ethoxymethyl, 3-hydroxypropyl, allyl, 3-phenylprop-3-en-1-yl, prop-2-yn-1-yl, 3-phenylprop-2-yn-1-yl, 3-(2-chlorophenyl)prop-2-yn-1-yl, but-2-yn-1-yl, cyclopentyl, cyclohexyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylpropyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, furan-2-ylmethyl, furan-3-methyl, tetrahydrofuran-2-ylmethyl, tetrahydrofuran-2-ylmethyl, phenylpropyl, 4-chlorophenylpropyl, 4-methylphenylpropyl, 4-methoxyphenylpropyl, benzyl, 4-chlorobenzyl, 4-methylbenzyl, or 4-methoxybenzyl; R 3 represents hydrogen, methyl, ethyl, benzyl, 4-chlorobenzyl, 4-hydroxybenzyl, phenyl, cyclohexyl, cyclohexylmethyl, pyridin-3-ylmethyl, tert-butoxymethyl, naphthylmethyl, iso-butyl, sec-butyl, tert-butyl, 1-benzylthio-1-methylethyl, 1-methylthio-1-methylethyl, 1-mercapto-1-methylethyl, 1-methoxy-1-methylethyl, 1-hydroxy-1-methylethyl, 1-fluoro-1-methylethyl, hydroxymethyl, 2-hydroxethyl, 2-carboxyethyl, 2-methylcarbamoylethyl, 2-carbamoylethyl, or 4-aminobutyl; and R 4 represents hydrogen, or methyl; and (a) R 5 and R 6 independently represent: hydrogen, halogen, trifluoromethyl, or (C 1 â€“C 6 )alkyl, (C 2 â€“C 6 )alkenyl, (C 2 â€“C 6 )alkynyl, aryl, heterocyclyl, aryl(C 1 â€“C 6 )alkyl-, or heterocyclyl(C 1 â€“C 6 )alkyl-, any of which may be optionally substituted by (C 1 â€“C 6 )alkyl, halogen, trifluoromethyl, cyano, nitro, oxo, phenoxy or phenylthio-, â€”OR A , â€”SR A , â€”NHR A , â€”NR A R B , â€”NHCOR A , â€”CONHR A , â€”CONR A R B , or â€”COOR A , wherein R A and R B are independently hydrogen or (C 1 â€“C 4 )alkyl, or in the case where R A and R B are attached to a nitrogen atom then R A and R B taken together with the nitrogen atom to which they are attached form a monocyclic 5â€“7 membered ring; or (b) R 5 and R 6 taken together with the carbon atoms to which they are attached form a fused monocyclic or bicyclic carbocyclic ring which may be further substituted with any of the substituent groups listed under (a).