Patent ID: 8853249

Claim:
A method for producing a macrocycle compound according to the following general formula (I) wherein R 1 and R 2 independently are hydrogen, C 1 -C 4 alkyl which is unsubstituted or substituted by OH, or C 1 -C 4 alkoxy; R 3 is hydrogen, C 1 -C 4 alkoxy, C 1 -C 8 alkyl which is unsubstituted or substituted by OH or OR, wherein R is selected from hydrogen, C 1 -C 4 alkyl, aryl or acetyl, or C 1 -C 4 alkoxy, R 4 is hydrogen, halogen, C 1 -C 4 alkyl which is unsubstituted or substituted by OH, or C 1 -C 4 alkoxy; R 5 is hydrogen or halogen; R 6 is hydrogen or C 1 -C 1 alkyl; R 7 is hydrogen or C 1 -C 4 alkyl which is unsubstituted or substituted by OH, or C 1 -C 4 alkoxy; and X is C=CH 2 or CHR 8 wherein R 8 is C 1 -C 4 alkyl which is unsubstituted or substituted by —S—C 1 -C 4 alkyl, and stereoisomers and pharmaceutically acceptable salts thereof, comprising a synthesis of optionally protected 4-methoxy-tryptophan according to formula 2: or the formula: