Patent ID: 8268834

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are each independently selected from hydrogen and C 1 -C 6 alkyl; Y is selected from —C(O)C 3 -C 8 cycloalkyl, —C(O)aryl, and —C(O)heteroaryl, where the cycloalkyl, aryl and heteroaryl ring systems are each optionally substituted by one or more substituents selected from List X; A is N; List X is represented by hydroxy, halo, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 8 cycloalkyl, C 1 -C 3 alkyl-C 3 -C 8 cycloalkyl, —OC 1 -C 6 -alkyl, —OC 3 -C 8 cycloalkyl, —OC 1 -C 3 alkyl-C 3 -C 8 cycloalkyl, where each of the alkyl groups are optionally substituted by one or more halogen, hydroxy, or cyano; Ar′ is a group wherein E is N or CR e ; R a is selected from H, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, OC 1 -C 6 alkyl and —OC 1 -C 6 haloalkyl; R b is selected from H, —NR 40 R 41 , halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OC 1 -C 6 alkyl and —OH; R c is (CH 2 ) c NR 44 S(O) 2 R 45 ; R d is selected from H, C 1 -C 6 alkyl and —OC 1 -C 6 alkyl; R e is selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl and halo; R 40 , R 42 and R 44 are each independently selected from H and C 1 -C 6 alkyl; R 41 and R 43 are each independently selected from H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 3 alkyl-C 3 -C 6 cycloalkyl, C 1 -C 3 alkyl-aryl, C 1 -C 3 alkyl-heterocyclyl, aryl, heterocyclyl, C(O)C 1 -C 6 alkyl and C 1 -C 3 alkyl-OC 1 -C 3 alkyl, wherein the cycloalkyl ring is optionally substituted by one or more substituents selected from —OH and —NH 2 ; R 45 is selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 3 alkyl-C 3 -C 6 cycloalkyl, —NR 42 R 43 , aryl and heterocyclyl; a and b are each independently 0, 1, 2, or 3; c is 1 or 2; and heterocyclyl is a 5- to 7-membered nitrogen-containing heterocyclic group which is optionally substituted by one or more groups selected from —OH, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 3 alkyl-C 3 -C 6 cycloalkyl and C 1 -C 3 hydroxyalkyl; provided that when Y is a ketone group, then Ar′ is not a phenyl group substituted in the 3-position by a benzyl substituted amide group.