Patent ID: 7638138

Claim:
A granular composition for nasal administration, which comprises: a) a powdered pharmaceutical, and b) as a carrier thereof, a substantially water-insoluble crystalline cellulose powder, wherein the pharmaceutical is selected from growth hormone, calcitonin, glucagon, glucagon-like peptide-1, interferon, interleukin, erythropoietin, luteinizing hormone-releasing hormone, somatostatin, vasopressin, oxytocin, enkephalin, adrenocorticotropic hormone, growth hormone-releasing hormone, granulocyte colony formation-stimulating factor, parathyroid hormone, thyroid-stimulating hormone-releasing hormone, angiotensin, prolactin, luteinizing hormone, gastric inhibitory polypeptide (GIP), C-peptide, cyclosporine, and FK-506, and parathyroid hormone (1-34); wherein the crystalline cellulose powder has a sieving particle diameter distribution of: 10 wt % or fewer particles with a diameter smaller than 25 μm; 20 to 60 wt % particles with a diameter of 25 to 38 μm; 20 to 60 wt % particles with a diameter greater than 38 μm and smaller than or equal to 53 μm; and the remaining particles having a diameter greater than 53; and wherein the crystalline cellulose powder has a bulk density of 0.22 to 0.40 g/cm 3 .