Patent ID: 8343961

Claim:
A compound of formula I: or a salt or ester thereof, wherein: one of Z 1 and Z 2 is CR 3 the other is N; X 2 and X 4 are independently C(O) or CH 2 ; X 3 is CR a R b ; Y is unsubstituted or substituted C 1 -C 6 alkyl linker or a bond; m is 0, 1, 2, 3, 4; R 1 is unsubstituted or substituted C 5 -C 10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S, C(O)R c or S(O) 2 R c ; R 3 is H, halogen, unsubstituted or substituted C 1 -C 8 alkyl, unsubstituted or substituted C 5 -C 10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S; each R 4 is independently hydroxyl, halogen, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 1 -C 6 alkoxyl, amino, unsubstituted or substituted C 1 -C 6 alkylamino, unsubstituted or substituted di-(C 1 -C 6 ) alkylamino, unsubstituted or substituted C 5 -C 10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S or any two adjacent R 4 's, together with the atoms to which they are attached, form a 5- to 7-member ring optionally comprising 1-4 heteroatoms selected from N, O and S; R a and R b are independently H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 5 -C 10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S; and R c is H, unsubstituted or substituted C 1 -C 8 alkyl, unsubstituted or substituted C 5 -C 10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S.