Patent ID: 7091356

Claim:
A substantially chirally pure (R)- or a substantially chirally pure (S)-, or mixture of (R)- and (S)-hydroxamic acid derivative selected from the group consisting of (a) compounds of the formula: wherein each of R 1 and R 2 , when taken independently of each other, is hydrogen, lower alkyl, or R 1 and R 2 , when taken together, together with the depicted carbon atoms to which each is bound, is o-phenylene, o-naphthylene, or cyclohexene-1,2-diyl, unsubstituted or substituted with 1 to 4 substituents each selected independently from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkylamino, dialkylamino, acylamino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, cycloalkoxy of 3 to 6 carbon atoms, C 4 –C 6 -cycloalkylidenemethyl, C 3 –C 10 -alkylidenemethyl, indanyloxy, and halo; R 3 is phenyl substituted with from one to four substituents selected from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, cycloalkoxy of 3 to 6 carbon atoms, and halo; or C 4 –C 6 -cycloalkylidenemethyl, C 3 –C 10 -alkylidenemethyl; and R 4 is hydrogen, alkyl of 1 to 10 carbon atoms, phenyl, or benzyl; R 4′ is hydrogen or alkyl of 1 to 6 carbon atoms; R 5 is —CH 2 —, —CH 2 —CO—, —CO—, —SO 2 —, —S—, or —NHCO—; and n has a value of 0, 1, or 2; and (b) the acid addition salts of said compounds which contain a nitrogen atom capable of being protonated.