Patent ID: 7314879

Claim:
A compound of formula I: or a pharmaceutically acceptable salt, or stereoisomer thereof, wherein: L and L 1 combine together to form an oxo group; E is: O, S, NR 1b , SO, SO 2 , CR 9 , or C(R 9 ) 2 wherein R 9 combines with an adjacent R 1 to form a 5, 6, or 7-member saturated or unsaturated carbocycle; wherein the Z ring has 0 or 1 double bond between the C(R 9 ) carbon and an adjacent carbon attached to R 1 ; R 1 is selected from the group consisting of: hydrogen, and C 1 -C 8 alkyl, R 1a is C 1 -C 8 alkyl, (D)C 3 -C 7 cycloalkyl, (D)phenyl, (D)aryl, wherein C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, phenyl, and aryl are optionally substituted with one to five substituents independently selected from the group consisting of halo, hydroxy, C 1 -C 8 alkyl, C 1 -C 4 alkoxy, and C 1 -C 4 haloalkyl; provided that halo and hydroxy groups are not substituted on a carbon atom adjacent to a heteroatom; R 1b is: hydrogen, C 1 -C 8 alkyl, (D)C 3 -C 7 cycloalkyl, SO 2 (C 1 -C 8 alkyl), (D)C(O)C 1 -C 4 alkyl, (D)C(O)OC 1 -C 4 alkyl, or SO 2 (D)phenyl, wherein the phenyl group is optionally substituted with one to five substituents selected from halo, and C 1 -C 8 alkyl; R 2 is: hydrogen, or C 1 -C 8 alkyl; R 3 is: phenyl, aryl or thienyl; wherein phenyl, aryl and thienyl are optionally substituted with one to three substituents independently selected from the group consisting of: cyano, perfluoroC 1 -C 4 alkoxy, halo, C 1 -C 8 alkyl, (D)C 3 -C 7 cycloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl; R 4 is: hydrogen, C 1 -C 8 alkyl, T is: R 9 is independently: hydrogen, (C 1 -C 8 ) alkyl, C 2 -C 8 alkenyl, C(O)C 1 -C 8 alkyl, or phenyl, R 10 is: hydrogen, (C 1 -C 8 ) alkyl, C(O)C 1 -C 8 alkyl, or phenyl, R 11 is independently: hydrogen, (C 1 -C 8 ) alkyl, (D)phenyl, or aryl; R 12 is independently: C 1 -C 8 alkyl, phenyl, aryl; D is: a bond or C 1 -C 4 alkyl; g is: 0, 1, or 2; y is: 1 n is: 0-8; and p is 0-4.