Patent ID: 8067030

Claim:
A method of treating prostatic cancer, prostatic hyperplasia, endometriosis, uterine myoma, uterine fibroma, precocious puberty, dysmenorrhea or breast cancer or a method of contraception, comprising administrating administering to a mammal in need thereof an effective amount of a controlled release composition comprising a LH-RH derivative or salt thereof wherein the LH-RH derivative is a peptide of the formula: 5-oxo-Pro-His-Trp-Ser-Tyr-Y-Leu-Arg-Pro-Z [wherein, Y represents DLeu, DAla, DTrp, DSer(tBu), D2Nal or DHis(ImBzl), and Z represents NH—C 2 H 5 or Gly-NH 2 ] or a salt thereof, and a lactic acid polymer or salt thereof having a weight-average molecular weight of 15,000 to 50,000, in which a content of polymers having molecular weights of 5,000 or less is about 5% by weight or less; wherein the controlled release composition does not contain hydroxynaphthoic acid or salt thereof.