Patent ID: 7667055

Claim:
A process for the production of a polycyclic fused ring compound corresponding to Formula (10): the process comprising treating a polycyclic fused ring polyol with a bridging silicon-based protecting group and a side chain precursor, wherein the polycyclic fused ring polyol corresponds to Formula (3): the bridging silicon-based protecting group corresponds to Formula (4): the side chain precursor corresponds to Formula (6) X 2 is alkyl, alkenyl, alkynyl, aryl, heterocyclo, —OX 6 , —SX 7 , or —NX 8 X 9 ; X 3 is substituted or unsubstituted alkyl, alkenyl, alkynyl, phenyl, or heterocyclo; X 5 is —COX 10 , —COOX 10 , or —CONHX 10 ; X 6 is acyl, alkyl, alkenyl, alkynyl, aryl, heteroaryl, hydrogen, or hydroxy protecting group; X 7 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or sulfhydryl protecting group; X 8 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or heterocyclo; X 9 is an amino protecting group; X 10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo; L 1 and L 2 are independently amine, halide, or sulfonate leaving groups; Z is —CH 2 —CH 2 —, —O—Si(CH 3 )(CH 3 )—O—, or —O—; and the dashed lines denote the skeletal structure of the polycyclic fused ring polyol.