Patent ID: 7947665

Claim:
A method for protecting intestinal and hematopoietic cells of a mammalian subject from apoptosis caused by radiation exposure or chemotherapy, the method comprising administering to the subject a therapeutically effective amount of a composition comprising a compound of formula (I) wherein, X 1 is R 1 —Y 1 -A-; X 2 is —Z 1 —P(S)(OH) 2 ; X 3 is hydrogen; A is a direct link or (CH 2 ) l with l being an integer from 1-30; Y 1 is (CH 2 ) l with l being an integer from 1-30; Z 1 is oxygen; Q 1 and Q 2 are independently selected from the group consisting of two hydrogens, ═NR 4 , ═O, and a combination of H and —NR 5 R 6 ; R 1 is independently a straight or branched-chain C 1 to C 30 alkyl, a straight or branched-chain C 2 to C 30 alkenyl, an aromatic or heteroaromatic ring (optionally substituted), an acyl, an arylalkyl, an aryloxyalkyl, R 4 , R 5 , R 6 , R 7 , and R 8 are independently hydrogen, a straight or branched-chain C 1 to C 30 alkyl, a straight or branched-chain C 2 to C 30 alkenyl, an aromatic or heteroaromatic ring with or without mono-, di-, or tri-substitutions of the ring, an acyl, an arylalkyl, or an aryloxyalkyl including straight or branched-chain C 1 to C 30 alkyl.