Patent ID: 8865713

Claim:
A compound having PHD inhibitor activity of the formula (I): wherein: n is 2-4; each R 1 is independently selected from H, halo, —C 1-4 -alkyl, —C 3-8 cycloalkyl, —C 1-4 perhaloalkyl, trifluoroC 1-4 -alkoxy, —OH, —NO 2 , —CN, CO 2 H, —OC 1-4 alkyl, —SC 1-4 -alkyl, —S(C 1-4 -alkyl)-R c , —S(O) 2 (C 1-4 alkyl)-R c , —S(O)—C 1-4 -alkyl, —SO 2 —C 1-4 alkyl, —S—R c , —S(O)—R c , —SO 2 —R c , —SO 2 —NH—R c , —O—R c , —CH 2 —O—R c , —C(O)NH—R c , —NR a R b , benzyloxy optionally substituted with R d , phenyl optionally substituted with R d , —C 3-8 cycloalkyl optionally containing one or more O, S or N wherein said —C 3-8 cycloalkyl is optionally substituted with R d , and two adjacent R 1 groups may be joined to form an optionally substituted 3-8 member ring optionally containing one or more O, S or N; R a and R b are each independently H, C 1-4 -alkyl, —C(O)C 1-4 alkyl, —C(O)—R c , —C(O)CH 2 —R e , C 1-4 alkyl-R e , —SO 2 —R c , —SO 2 —C 1-4 -alkyl, phenyl optionally substituted with R d , benzyl optionally substituted with R d or monocyclic heteroaryl ring optionally substituted with R d ; or R a and R b can be taken together with the nitrogen to which they are attached to form an optionally substituted monocyclic heterocycloalkyl ring optionally containing one or more heteroatoms; R c is —C 3-8 cycloalkyl, phenyl optionally substituted with R d , benzyl optionally substituted with R d , or a monocyclic heteroaryl ring optionally substituted with R d ; R d is independently —H, halo, —OH, —C 1-4 alkyl or —C 1-4 perhaloalkyl, trifluoroC 1-4 alkoxy, —OC 1-4 alkyl, —O-phenyl, or —O-benzyl; R e is —C 3-8 heterocycloalkyl optionally containing one or more O, S or N; R 2 and R 3 are both H, —CF 3 , or C 1-3 alkyl; each Z is C or N, provided that no more than two Z's can simultaneously be N; and further provided that when all Z's are C, two adjacent R 1 groups are joined to form an optionally substituted 3-8 member ring optionally containing one or more O, S or N; or an enantiomer, a diastereomer, a racemate, or a pharmaceutically acceptable salt thereof.