Patent ID: 8722041

Claim:
An isolated monoclonal anti-human Equilibrative Nucleoside Transporter 1 (hENT1) antibody or antigen-binding fragment thereof, wherein said antibody comprises: (a) a variable heavy chain complementarity determining region 1 (VH CDR1) sequence comprising the amino acid sequence GYTFTDYE (SEQ ID NO: 10); (b) a variable heavy chain complementarity determining region 2 (VH CDR2) sequence comprising the amino acid sequence IDPETGAI (SEQ ID NO: 11); (c) a variable heavy chain complementarity determining region 3 (VH CDR3) sequence comprising the amino acid sequence TREFTY (SEQ ID NO: 12); (d) a variable light chain complementarity determining region 1 (VL CDR1) sequence comprising the amino acid sequence QSLLFSNGKTY (SEQ ID NO: 24); (e) a variable light chain complementarity determining region 2 (VL CDR2) sequence comprising the amino acid sequence LVS (SEQ ID NO: 25); and (f) a variable light chain complementarity determining region 3 (VL CDR3) sequence comprising the amino acid sequence VQGTHFPWT (SEQ ID NO: 26) wherein said antibody or antigen-binding fragment thereof binds hENT1.