Patent ID: 6861445

Claim:
A method of treating, or inhibiting a ras-associated disease selected from lung cancer, lung adenocarcinoma, pancreatic cancers, pancreatic carcinoma, exocrine pancreatic carcinoma, colon cancers, colorectal carcinomas, colon adenocarcinoma, colon adenoma, myeloid leukemias, acute myelogenous leukemia (AML), thyroid cancer, thyroid follicular cancer, myelodysplastic syndrome (MDS), bladder carcinoma, epidermal carcinoma, breast cancer, prostate cancer, neuro-fibromatosis, restenosis, endometriosis, and psoriasis, and controlling metastasis, suppressing angiogenesis, and inducing apoptosis, by inhibiting farnesyl-protein transferase(FPTase) enzyme in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I) wherein: R 1 is a moiety R 2 is a moiety n is an integer of 1 and 3 to 9; m is an integer of 0 or 2; R 3 and R 4 are independently selected from the group consisting of hydrogen, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, halogen, nitro, trifluoromethoxy, phenoxy said phenoxy being optionally mono or disubstituted with substituents independently selected from alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, halogen, nitro, trifluoromethyl, trifluoromethoxy, methanesulphonyl, phenyl, phenoxy, and benzyloxy, said benzyloxy being optionally mono or disubstituted with substituents independently selected from alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, halogen, nitro, trifluoromethyl, trifluoromethoxy, methanesulphonyl, phenyl, phenoxy, and benzyloxy; R 5 , and R 6 , are independently selected from the group consisting of hydrogen, alkyl of 1 to 10 carbon atoms, halogen, nitro, phenyl said phenyl being optionally mono or disubstituted with substituents independently selected from alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, halogen, nitro, trifluoromethyl, trifluoromethoxy, methanesulphonyl, phenyl, phenoxy, and benzyloxy, said phenoxy being optionally mono or disubstituted with substituents independently selected from alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, halogen, nitro, trifluoromethyl, trifluoromethoxy, methanesulphonyl, phenyl, phenoxy, and benzyloxy, trifluoromethyl, trifluoromethoxy, and methanesulphonyl; or a pharmaceutically acceptable salt thereof.