Patent ID: 7396818

Claim:
A method of inhibiting a heparin/heparan sulfate sulfotransferase by contacting the heparin/heparan sulfate sulfotransferase with a hexuronic acid derivative represented by the following formula 1 or a salt thereof, wherein the heparin/heparan sulfate sulfotransferase has activity to transfer a sulfate group to a hydroxyl group at 6-position of a glucosamine residue or to a hydroxyl group at 2-position of a hexuronic acid residue in a heparin skeleton, wherein each of R 1 , R 2 , and R 3 independently represent(s) SO 3 − or H, provided that at least one thereof represents SO 3 − ; X represents OR 4 , R 4 independently represents H, alkyl which may have a substituent selected from alkoxy group and acyloxy group, alkenyl, alkynyl, acyl, aryl, or aralkyl group; one of R 5 and R 6 represents COOH while the other represents H; and the wavy line represents α-glycosidic bond or β-glycosidic bond, wherein said acyl group is represented as —CO—R 7 in which R 7 represents a group selected from alkyl which may have a substituent selected from alkoxy group and acyloxy group, alkenyl, alkynyl, aryl, and aralkyl groups.