Patent ID: 6891050

Claim:
A process for the preparation of intermediates 2′ comprising: a) suspending 10-DAB in a haloalkane and then treating the suspension with a haloalkyl acid chloride or a dihaloalkyl acid chloride in the presence of an activating agent and an organic base at temperature between −20-40° C. to obtain 7-O-haloacyl taxane 2′a along with minor amount of 7,10-dihaloacyl taxane 2′b; b) treating 7-O-(2-haloacyl)trihydroxyl taxane ie 2′a thus obtained with acetyl chloride or acetic anhydride in the presence of an amine and a solvent at −20 to +4° C. to obtain 7-O-(2-haloacyl)-10-acetyl-dihydroxy taxanes 2′c.