Patent ID: 7722872

Claim:
A method for treating a cancer, comprising: administering to an individual in need of such treatment a monoclonal antibody that recognizes a human 8F4 polypeptide, wherein said 8F4 polypeptide: a) is an inducible T cell costimulatory molecule; b) occurs on two-signal-activated CD4 + T lymphocytes from human peripheral blood; c) exhibits a molecular weight of about 55 to 60 kilodaltons as determined by non-reducing SDS-PAGE; d) is a dimer of two peptide chains exhibiting molecular weights of about 27 kilodaltons and 29 kilodaltons, as measured by reducing SDS-PAGE; and e) is recognized by the antibody produced by the hybridoma deposited with the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (“DSMZ”) and assigned accession no. DSM ACC2539, in an amount sufficient to ameliorate a symptom of said cancer, such that the cancer is treated.