Patent ID: 7902248

Claim:
A compound of formula (I): wherein: R 1 , R 2 are, independently, hydrogen, halo, amino, hydroxyamino, cyano, nitro, lower alkyl, -OR 5 , -C(O)OR 6 , perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, lower alkoxy lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, lower alkoxy lower alkyl sulfinyl, perfluoro-lower alkyl sulfinyl or sulfonamido; R 3 is cycloalkyl, having from 3 to 7 carbon atoms, or lower alkyl; R 4 is benzothiazole, unsubstituted or substituted with lower alkyl, halo, alkoxy or oxo, urea, or an unsubstituted or monosubstituted five-or six-membered heteroaromatic ring connected by a ring carbon atom to the amine group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom, said monosubstituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom or nitrogen other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, perfluoro- lower alkyl, oxo, —(CH 2 ) n —OR 7 , —(CH 2 ) n —C(O)—OR 7 , —(CH 2 ) n —C(O)—NH—R 7 , —C(O)C(O)—OR 7 , —(CH 2 ) n —NHR 7 , —(CH 2 ) m -Ph, —(CH 2 ) m —Ph—C(O)OR 7 , —(CH 2 ) m —Ph—C(O)NH 2 , —(CH 2 ) m —Ph—NH—C(O)R 7 or —(CH 2 ) m -het; R 5 is hydrogen, lower alkyl, or perfluoro-lower alkyl; R 6 is lower alkyl; R 7 is hydrogen or lower alkyl; n is 0, 1, 2, 3 or 4; wherein n is not zero if a nitrogen-oxygen bond results; m is 1, 2, 3 or 4; het is a five- or six-membered heteroaromatic ring; and Δ is a trans configuration across the double bond; or a pharmaceutically acceptable salt thereof.