Patent ID: 7935852

Claim:
A method for the production of an aromatic or hetroaromatic fluorine-labelled compound comprising fluoridation of an iodonium salt of Formula (I) or (II): wherein: Q=phenyl, or phenyl substituted with one or more of acetyl, C1-3 alkyl or —O—C1-3 alkyl each of R 1 -R 5 is independently selected from hydrogen, C 1-3 alkyl and —O—(C 1 -C 3 alkyl); and Y − is a counter ion such as trifluoromethane sulfonate (triflate), perfluoro C 2 -C 10 alkyl sulphonate, trifluoroacetate, methane sulfonate (mesylate), toluene sulfonate, (tosylate), tetraphenylborate; to give a product of general formula (III): Q-F (III) and wherein said fluoridation is carried out with a fluoride ion source characterised in that the reaction solvent is either 100% water or a mixture of water and a water miscible solvent.