Patent ID: 8852603

Claim:
A method of suppressing hypersecretion from an inflammatory cell in a patient in need thereof, said method comprising; administering an effective amount of a modified clostridial neurotoxin to said patient; wherein the modified clostridial neurotoxin comprises a clostridial toxin light chain and a clostridial toxin translocation domain in which the neuronal targeting activity of the clostridial neurotoxin has been removed; wherein said modified clostridial neurotoxin is covalently linked to a ligand that binds to a receptor on an inflammatory cell; wherein the inflammatory cell is an inflammatory cell selected from the group consisting of a mast cell, an eosinophil, a macrophage, a monocyte, a neutrophil, and a fibroblast; and wherein upon binding of the ligand to a receptor on an inflammatory cell, the light chain is translocated into the cytosol of the cell by the translocation domain and cleaves one or more SNARE proteins essential to exocytosis in the cell.