Patent ID: 8778940

Claim:
A method of inducing Mef2 expression in a stem cell comprising contacting said stem cell with a compound of formula (II): wherein: R 1 is substituted or unsubstituted thiophenyl or a substituent of formula (A): wherein: R A , R B and R C are each independently selected from the group consisting of hydrogen, halogen, alkyl, aralkyl, aryl, cyano, or nitro, and a heteroatom unsubstituted C 1 -C 10 acyl; and G is O, —NH, or S; R 2 is hydrogen, hydroxy, halogen, nitro, aryl, alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, aralkyl, —CHO, —C(O)R 9 , —OC(O)R 9 , —OC(O)OR 9 , —O(CN)OR 9 , —C(O)NR 9 R 10 , —OC(O)NR 9 R 10 , —NR 9 OR 5 , or —SO 3 R 9 ; wherein R 9 and R 10 are each independently hydrogen, alkyl, aryl, or aralkyl; R 3 is —NH—O-alkyl, —NH—OH, —OR 11 or —NR 11 R 12 , wherein R 11 and R 12 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; or R 11 is H and R 12 is a cyclic group; or R 11 and R 12 together with the nitrogen to which they are bound form a cyclic group; X is O or —NR 13 , wherein R 13 is hydrogen, alkyl, aryl, or aralkyl; or a stereoisomer, solvate, hydrate, or pharmaceutically acceptable salt thereof.