Patent ID: 6974817

Claim:
A compound of the formula or the pharmaceutically acceptable salts thereof; wherein a=0-5, b=0-2, c=0-2 d=0-4 X is —O—, —S—, —CH 2 —, —NR 6 — Y is (C 6 -C 10 )aryl, or (C 2 -C 9 )heteroaryl, each R 1 is independently selected from the group consisting of: H—, HO—, halo-, (C 1 -C 8 )alkyl-optionally substituted with 1-3 fluorine atoms, (C 1 -C 8 )alkyl-O— wherein the alkyl group is optionally substituted with 1-3 fluorine atoms, HO—(C 1 -C 8 )alkyl-, NC—, H 2 N—, H 2 N—(C 1 -C 8 )alkyl-, HO—(C═O)—, (C 1 -C 8 )alkyl-(C═O)—, (C 1 -C 8 )alkyl-(C═O)—(C 1 -C 8 )alkyl-, H 2 N—(C═O)—, H 2 N—(C═O)—(C 1 -C 8 )alkyl-; each R 2 and R 3 is independently selected from the group consisting of: H—, oxo, (C 1 -C 8 )alkyl- substituted with 1-3 fluorine atoms, (C 1 -C 8 )alkyl-, (C 3 -C 8 )cycloalkyl-, (C 3 -C 8 )cycloalkyl-(C 1 -C 8 )alkyl-, (C 6 -C 10 )aryl-, (C 6 -C 10 )aryl-(C 1 -C 8 )alkyl-, HO—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-O—(C 1 -C 8 )alkyl-, H 2 N—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-NH—(C 1 -C 8 )alkyl-, [(C 1 -C 8 )alkyl] 2 N—(C 1 -C 8 )alkyl-, (C 2 -C 9 )heterocyclyl-(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-(C═O)—NH—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-O—(C═O)—NH—(C 1 -C 8 )alkyl-, H 2 N—(C═O)—NH—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-SO 2 —NH—(C 1 -C 8 )alkyl-, (C 2 -C 9 )heteroaryl-(C 1 -C 8 )alkyl-, H 2 N—(C═O)—, H 2 N—(C═O)—(C 1 -C 8 )alkyl-; each R 4 is independently selected from the group consisting of: H—, HO—, halo-, NC—, HO—(C═O)—, H 2 N—, (C 1 -C 8 )alkyl-NH—, [(C 1 -C 8 )alkyl] 2 N—, (C 1 -C 8 )alkyl-optionally substituted with 1-3 fluorine atoms, (C 1 -C 8 )alkyl-O— wherein the alkyl group is optionally substituted with 1-3 fluorine atoms, HO—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-O—(C 1 -C 8 )alkyl-, H 2 N—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-NH—(C 1 -C 8 )alkyl-, [(C 1 -C 8 )alkyl] 2 N—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-(C═O)—, (C 1 -C 8 )alkyl-(C═O)—(C 1 -C 8 )alkyl-, (C 6 -C 10 )aryl-, (C 2 -C 9 )heteroaryl-, (C 6 -C 10 )aryloxy-, H 2 N—(C═O)—, H 2 N—(C═O)—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-NH—(C═O)—, (C 1 -C 8 )alkyl-NH—(C═O)—(C 1 -C 8 )alkyl-, [(C 1 -C 8 )alkyl] 2 N—(C═O)—, [(C 1 -C 8 )alkyl] 2 —N—(C═O)—(C 1 -C 8 )alkyl-, (C 3 -C 8 )cycloalkyl-, (C 1 -C 8 )alkyl-SO 2 —, NC—(C 1 -C 8 )alkyl-, (C 1 -C 8 )alkyl-(C═O)—NH—, H 2 N—(C═O)—NH—, H 2 N—(C═O)—NH—(C 1 -C 8 )alkyl-; R 5 is (C 1 -C 8 )alkyl-.