Patent ID: 8846620

Claim:
A method of enhancing blood coagulation in a subject, the method comprising: orally administering to the subject a procoagulant amount of a non-anticoagulant sulfated polysaccharide (NASP) selected from the group consisting of N-acetyl-heparin (NAH), N-acetyl-de-O-sulfated-heparin (NA-de-o-SH), de-N-sulfated-heparin (De-NSH), de-N-sulfated-acetylated-heparin (De-NSAH), periodate-oxidized heparin (POH), chemically sulfated laminarin (CSL), chemically sulfated alginic acid (CSAA), chemically sulfated pectin (CSP), dextran sulfate (DXS), heparin-derived oligosaccharides (HDO), pentosan polysulfate (PPS), fucoidans, sulfated maltopentoses, sulfated beta-cyclodextrins, sulfated 6-Carboxyicodextrin in combination with a gastrointestinal epithelial barrier permeation enhancer in a manner sufficient to enhance blood coagulation in the subject, wherein the gastrointestinal epithelial barrier permeation enhancer comprises a ratio of chitosan to bromelain sufficient to enhance permeation 2-fold or greater than would be achieved by the sum of chitosan or bromelain individually.