Patent ID: 8658650

Claim:
A compound having a structure represented by a formula: wherein R is four substituents independently selected from hydrogen, halogen, hydroxyl, methoxy, nitrile, nitro, thiol, optionally substituted amino, alkyl, C 1-6 alkyl, cycloalkyl, C 3-10 cycloalkyl, alkoxy, aryl, heteroaryl, and CONR 7 R 8 , CF 3 ; wherein each R 1 is one or more substituents independently selected from hydrogen, halogen, hydroxyl, methoxy, alkoxy, nitrile, nitro, thiol, optionally substituted amino, aryl, heteroaryl, CF 3 , alkyl, C 1-6 alkyl, cycloalkyl, C 3-10 cycloalkyl, and CONR 7 R 8 ; wherein each R 2 is one or more substituents independently selected from hydrogen, halogen, hydroxyl, methoxy, alkoxy, nitrile, nitro, thiol, optionally substituted amino, aryl, heteroaryl, CF 3 , NR 7 R 8 , alkyl, C 1-6 alkyl, cycloalkyl, C 3-10 cycloalkyl, and CONR 7 R 8 , SO 2 NR 7 R 8 ; wherein R 3 is hydrogen, NH, alkyl, substituted alkyl, alkoxy, substituted alkoxy, mono or disubstituted amino, and amide; wherein R 5 and R 6 are independently hydrogen, halogen, carbonyl, thiocarbonyl, CF 3 , nitrile, alkyl, C 1-6 alkyl, cycloalkyl, C 3-10 cycloalkyl, or 3-8 membered ring comprising C, O, S, and/or N; wherein R 7 and R 8 are independently hydrogen, halogen, alkyl, C 1-6 alkyl, cycloalkyl, C 3-10 cycloalkyl, alkoxy, aryl, heteroaryl, nitrile, CF 3 ; wherein M is NR 3 , CR 5 R 6 ; wherein K is NR 3 , CR 5 R 6 ; wherein Y is C 3 -C 12 cycloalkyl or C 3 -C 12 cycloalkenyl or aryl or heteroaryl or C 3 -C 12 heterocycloalkyl or C 3 -C 12 heterocycloalkenyl or 3-8 membered ring comprising C, O, S, and/or N; wherein Z is C 3 -C 12 cycloalkylene or C 3 -C 12 cycloalkenylene or arylene or heteroarylene or C 3 -C 12 heterocycloalkylene or C 3 -C 12 heterocycloalkenylene; wherein k is an integer from 0 to 25; wherein m is an integer from 0 to 24; and wherein each n is independently an integer from 0 to 1; or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof; provided that (i) when all of R and R 3 are hydrogen and Z is 1,4-phenylene, Y is not furan-2-yl, thiophen-2-yl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2-fluorophenyl, 2-methoxyphenyl, or cyclohexyl; (ii) when all of R are hydrogen, and either R 3 is hydrogen or Z is 1,4-phenylene, Y is not furan-2-yl, thiophen-2-yl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2-fluorophenyl, 2-methoxyphenyl, or cyclohexyl; (iii) when all of R are hydrogen, Y is not furan-2-yl, thiophen-2-yl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2-fluorophenyl, 2-methoxyphenyl, or cyclohexyl; (iv) when R 3 is hydrogen, Y is not furan-2-yl, thiophen-2-yl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2-fluorophenyl, 2-methoxyphenyl, or cyclohexyl; (v) when Z is 1,4-phenylene, Y is not furan-2-yl, thiophen-2-yl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2-fluorophenyl, 2-methoxyphenyl, or cyclohexyl; and (vi) Y is not furan-2-yl, thiophen-2-yl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2-fluorophenyl, 2-methoxyphenyl, or cyclohexyl.