Patent ID: 7045303

Claim:
A method for identifying a compound capable of modulating a polycystin-1 mediated increase in cell adherence to type I collagen coated substrate, comprising; (a) contacting a test compound with a cell expressing a polycystin-1 protein wherein expression of said polycystin-1 protein results in an increase in cell adherence to type I collagen coated substrate; (b) measuring cell adherence to type I collagen coated substrate; and (c) comparing the level of cell adherence to type I collagen coated substrate obtained in (b) to the level of cell adherence to type I collagen coated substrate obtained in the presence of a vehicle control: wherein a decrease in the level of cell adherence to type I collagen coated substrate obtained in (b) compared to that obtained in the presence of a vehicle control, indicates identification of a compound capable of modulating polycystin-1 activity.