Patent ID: 6972287

Claim:
A method of inhibiting the aggregation of amyloid proteins to form amyloid deposits, the method comprising administering to a patient in need of inhibition of the aggregation of amyloid protein an amyloid protein aggregation inhibiting amount of a compound of Formula I wherein n is 0 to 5 inclusive; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are independently hydrogen, halogen, —OH, —NH 2 , NR b R c , —CO 2 H, —CO 2 C 1 -C 6 alkyl, —NO 2 , —OC 1 -C 12 alkyl, —C 1 -C 8 alkyl, —CF 3 , —CN, —OCH 2 phenyl, —OCH 2 -substituted phenyl, —(CH 2 ) m -phenyl, —O-phenyl, —O-substituted phenyl, —NH(CH 2 ) p NR b R c , —N(C 1 -C 6 alkyl)(CH 2 ) p NR b R c , R 8 is COOH, tetrazolyl, —SO 2 R d , or —CONHSO 2 R d ; R b and R c are independently hydrogen, —C 1 -C 6 alkyl, —(CH 2 ) m -phenyl, or R b and R c taken together with the nitrogen atom to which they are attached form a cyclic ring selected from piperidinyl, pyrrolyl, imidazolyl, piperazinyl, 4-C 1 -C 6 alkylpiperazinyl, morpholino, thiomorpholino, decahydroisoquinoline, or pyrazolyl; R d is hydrogen, —C 1 -C 6 alkyl, —CF 3 , or phenyl; m is 0 to 5 inclusive; p is 1 to 5 inclusive; A is CH; R 1 and R 2 , when adjacent to one another, can be methylene-dioxy; or the pharmaceutically acceptable salts thereof.