Patent ID: 8501746

Claim:
A compound of Formula (I): wherein, V is selected from —N(R 5 )C(O)—, —C(O)N(R 5 )—, —OC(O)N(R 5 )—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —O—, —N(R 5 )—, —S—, —S(O) t —, —N(R 5 )S(O) t —, —S(O) t N(R 5 )—, —OS(O) 2 —, —OS(O) 2 N(R 5 )—, —N(R 5 )C(═N(R 5a ))NR 5 —, —N(R 5 )C(═S)NR 5 —, —N(R 5 )((R 5a )N═)C—, —C(═N(R 5a ))N(R 5 )—, alkylene, alkenylene, alkynylene, aryl, heteroaryl, cycloalkyl, heterocyclyl or a direct bond; W is selected from —N(R 5 )C(O)—, —C(O)N(R 5 )—, —OC(O)N(R 5 )—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —O—, —N(R 5 )—, —S—, —S(O) t —, —N(R 5 )S(O) t —, —S(O) t N(R 5 )—, —OS(O) 2 N(R 5 )—, —C(O)—, —OC(O)—, —C(O)O—, —N(R 5 )C(═N(R 5 ))NR 5 —, —N(R 5 )((R 5a )N═)C—, —C(═N(R 5 ))N(R 5 )—, aryl, heteroaryl, heterocyclyl, alkynylene, alkenylene, alkylene or a direct bond; X is selected from C(H) or N; Y is selected from S, N(H) or N(CH 3 ); p is 0, 1, 2, or 3; t is 1 or 2; R 1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl; or R 1 is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from the group consisting of cycloalkyl, heterocyclyl, aryl and heteroaryl and where some or all of the rings may be fused to each other; R 2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, haloalkyl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl and heteroarylalkyl; R 3 is selected from the group consisting of alkyl, alkenyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, halo, haloalkyl, haloalkoxyl, cyano and —N(R 5 ) 2 ; R 4 is selected from the group consisting of alkyl, hydroxyalkyl, cycloalkylalkyl, aralkyl, halo, haloalkyl, —OCF 3 and —OC(H)F 2 ; R 5 is selected from the group consisting of hydrogen, aryl, alkyl, heteroaryl, heterocyclyl, haloalkyl, hydroxyalkyl, cycloalkylalkyl and aralkyl; R 5a is selected from the group consisting of hydrogen, alkyl, cycloalkylalkyl and cyano; a stereoisomer, enantiomer or tautomer thereof, a pharmaceutically acceptable salt thereof.