Patent ID: 8247445

Claim:
A platinum complex having the structure shown in formula I: wherein X and Y are, independently, any halogen, —NO 2 , —ONO, or the structure: or X and Y together form the structure: R 1 is —NO 2 or —ONO; R 2 is any halogen, —NH 2 , —OH, —ONO, —ONO 2 , —COR 10 , —OPO 3 R 10 R 11 , —OSO 3 H, —OSeOOH, —SeOOH, —AsO 2 , —OAsO 2 , —NR 10 R 11 , —NHR 10 R 11 , OCR 15 , alkyl, alkoxy, cycloalkyl, cycloalkoxy, aryl, aryloxy, alkycarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, heteroalkyl, heterocycloalkyl, heterocycloalkylcarbonyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocycloalkoxy, or heterocycloalkoxycarbonyl, any of which can be optionally substituted with any halogen, —COOH, —OH, —NO 2 , —NH 2 , —N-alkyl, alkyl, alkoxy, cycloalkyl, cycloalkoxy, aryl, aryloxy, alkycarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, heteroalkyl, heterocycloalkyl, heterocycloalkylcarbonyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocycloalkoxy, or heterocycloalkoxycarbonyl, or the structure: any of which can be substituted with any halogen, —NH 2 , —COOH, —OH, alkoxy, cycloalkoxy; R 3 is, independently, —NH 3 , or —NHR 7 ; R 7 is H, C 1-6 alkyl, alkoxy, or aryl, optionally substituted with —NO 2 or —COOH; R 10 and R 11 are, independently, H, —NH 2 , —OH, —NHR 7 , CONHR 7 , CON(R 7 ), C 1-6 alkyl, aryl, or heteroaryl, any of which can be optionally substituted with any halogen, —COOH, —OH, —NO 2 , —NH 2 , alkyl, alkoxy, cycloalkyl, cycloalkoxy, aryl, aryloxy, alkycarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, heteroalkyl, heterocycloalkyl, heterocycloalkylcarbonyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocycloalkoxy, or heterocycloalkoxycarbonyl, and wherein R 10 and R 11 are not both H; R 15 is alkyl, alkoxy, cycloalkyl, cycloalkoxy, aryl, aryloxy, alkycarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, heteroalkyl, heterocycloalkyl, heterocycloalkylcarbonyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocycloalkoxy, or heterocycloalkoxycarbonyl, any of which can be optionally substituted with any halogen, —COOH, —OH, —NO 2 , —NH 2 , —N-alkyl, alkyl, alkoxy, cycloalkyl, cycloalkoxy, aryl, aryloxy, alkycarbonyl, alkoxycarbonyl, cycloalkylcarbonyl, heteroalkyl, heterocycloalkyl, heterocycloalkylcarbonyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocycloalkoxy, or heterocycloalkoxycarbonyl; or a pharmaceutically acceptable salt thereof.