Patent ID: 8895530

Claim:
A method of reducing intraocular pressure (IOP) in a human subject in need thereof by administering about 0.05 mg/ml to about 7.0 mg/ml of a compound of Formula II, or a pharmaceutically acceptable salt thereof, to an affected eye of the human subject, wherein R 1 is selected from —(CO)C 1 -C 6 alkyl; —(CO)CH(halo) 2 ; —(CO)phenyl; —(CO)C 1 -C 10 optionally branched aliphatic; —(CO)C 3 -C 8 cycloalkyl which is optionally substituted with one or more of hydroxy or —(CH 2 ) n OH wherein n is 1-6; —(CO)aryl which is optionally substituted with one or more of hydroxy or —(CH 2 ) n OH wherein n is 1-6; and —(CO)C 3 -C 7 heterocyclyl which is optionally substituted with one or more of hydroxy or —(CH 2 ) n OH, wherein n is 1-6; R 2 is selected from —H and halo; and R 3 is selected from —H, hydroxy, —O(CO)CH(halo) 2 , —O(CO)(CH 2 ) 2 CH 3 , —O(CO)CH(CH 3 ) 2 , and —O(CO)CH 2 C(CH 3 ) 3 .