Patent ID: 8679780

Claim:
A method of stimulating the immune system of a mammal afflicted with an A-protein displaying carcinoma to produce an immune response thereto, the mammal having a detectable blood level of unacylated A-protein, the method comprising the steps of: (a) isolating an immunologically active antigen presenting cell (APC) from the mammal; (b) sensitizing the APC to A-protein by contacting the APC with a compound selected from the group consisting of an acylated peptide comprising a peptide having at least 10 amino acids including the amino terminal amino acid sequence SEQ ID NO:2 with a myristoyl group attached to the glycine residue of the peptide and a homopolymer of acylated A-protein monomers; and (c) administering the sensitized APC to the mammal, thereby relieving the immune system of its tolerance to unacylated A-protein and stimulating a T-cell-dependent response against the carcinoma.