Patent ID: 7645861

Claim:
A composition of matter of the formula (X 1 ) a —F 1 —(X 2 ) b and multimers thereof, wherein: F 1 is an immunoglobulin Fc domain comprising SEQ ID NO: 608 modified so that it comprises at least one X 3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS: 621, 622, 628, 624, 627, 632, 636, 639, 644, and 646 within a loop region of the immunoglobulin Fc domain, said loop region being in a non-terminal domain of the Fc domain; X 1 and X 2 are each independently selected from —(L 1 ) c —P 1 , —(L 1 ) c —P 1 —(L 2 ) d —P 2 , —(L 1 ) c —P 1 —(L 2 ) d —P 2 —(L 3 ) e —P 3 , and —(L 1 ) c —P 1 —(L 2 ) d —P 2 —(L 3 ) e —P 3 —(L 4 ) f —P 4 ; X 3 is independently selected from —(L 5 ) c —P 5 , —(L 5 ) c —P 5 —(L 6 ) d —P 6 , —(L 5 ) c —P 5 —(L 6 ) d —P 6 —(L 7 ) e —P 7 , and —(L 5 ) c —P 5 —(L 6 ) d —P 6 —(L 7 ) e —P 7 —(L 8 ) f —P 8 ; P 1 , P 2 , P 3 , and P 4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides; P 5 , P 6 , P 7 , and P 8 are each independently sequences of pharmacologically active peptides; L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , and L 8 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1.