Patent ID: 7351726

Claim:
A compound of the formula: or a pharmaceutically acceptable salt or ester form thereof, wherein: R 1 is hydrogen, halogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, or (C 6 -C 10 )aryl(C 1 -C 6 )alkyl; R 2 is hydrogen, halogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, C 4 -C 10 heteroaryl, (C 6 -C 10 )aryl(C 1 -C 6 )alkyl, or (C 4 -C 10 )heteroaryl(C 1 -C 6 )alkyl; R 3 and R 4 are independently hydrogen, C 1 -C 6 alkyl, or C 3 -C 8 cycloalkyl; X is O, S, or NR 5 ; R 5 is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, or arylalkyl; and n is an integer of 1 to 3, wherein said alkyl, whether used alone or as part of another group, is unsubstituted or substituted with halogen, cyano, nitro, oxo, hydroxy, acyloxy, C 1 -C 6 alkoxy, perhalo-(C 1 -C 6 )alkoxy, amino, amino substituted by one or two C 1 -C 6 alkyl groups, aminoacyl, acylamino, thio(C 1 -C 6 )alkoxy, or trihalomethyl; wherein said aryl, whether used alone or as part of another group, is unsubstituted or substituted with from 1 to 5 substituents selected from acyloxy, hydroxy, acyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, alkyl, perhalo-C 1 -C 6 alkoxy, amino, amino substituted by one or two C 1 -C 6 alkyl groups, aminoacyl, acylamino, azido, cyano, halo, nitro, thio(C 1 -C 6 )alkoxy, or trihalomethyl; and wherein said heteroaryl, whether used alone or as part of another group, is unsubstituted or substituted with from 1 to 5 substituents selected from acyloxy, hydroxy, acyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, amino, amino substituted by one or two C 1 -C 6 alkyl groups, aminoacyl, aclyamino, azido, cyano, halo, nitro, thio(C 1 -C 6 )alkoxy, or trihalomethyl.