Patent ID: 7759377

Claim:
A compound having the general formula (I): in which R 1 represents either a C 1-6 alkyl optionally substituted by one to three substituents selected from halogen, trifluoromethyl, hydroxyl, C 1-6 alkoxy, C 1-6 thioalkyl, thiophene and phenyl; or a C 3-7 cycloalkyl, or a thiophene, or a benzothiophene, or a pyridinyl, or a furanyl or a phenyl; the said phenyl groups being optionally substituted by one to three substituents selected from halogen, C 1-6 alkyl, C 1-6 alkoxy, hydroxyl, methylenedioxy, phenoxy, benzyloxy and trifluoromethyl; R 2 and R′ 2 represent, independently of one another, a substituent selected from hydrogen, halogen, hydroxyl, C 1-3 alkoxy, C 1-3 alkyl, C 3-7 cycloalkyl and O—C(O)—C 1-6 alkyl group, or R 2 and R′ 2 together form an oxo group; R 3 represents either hydrogen or C 1-6 alkyl optionally substituted by hydroxyl, C 1-6 cycloalkyl or C 1-3 alkoxy; R 4 is Z and R 5 is L or R 4 is L and R 5 is Z; wherein the group L is: in which G represents a C 1-7 alkyl or a single bond; M represents a C 3-7 cycloalkyl, a phenyl, a naphthyl or a pyridinyl, the group M being optionally substituted by one or more groups selected from halogen, hydroxyl, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, trifluoromethoxy and —O—CHF 2 ; and J represents hydrogen or a group —Y—K; wherein Y represents a single bond, oxygen, sulphur, —C 1-4 alkylene-, —O—C 1-4 alkylene- or —C 1-4 alkylene-O— or a group —N(W)—, the —C 1-4 alkylene-being optionally substituted by a hydroxyl or C 1-3 alkoxy; W represents either hydrogen, C 1-3 alkyl optionally substituted by phenyl, or phenyl; and K represents a phenyl or pyridinyl group, the group K being optionally substituted by one or more groups selected from halogen, hydroxyl, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, trifluoromethoxy and —O—CHF 2 ; Z represents CN, SO 2 NR 6 R 7 or a heteroaromatic group, the said heteroaromatic group being optionally substituted by a group R 8 ; R 8 representing either a C 1-4 alkyl which is itself optionally substituted by a CN, a phenyl or a phenoxy; or a phenyl; the said phenyl and phenoxy groups being optionally substituted by 1 to 3 groups selected from halogen, C 1-3 alkyl, C 1-3 alkoxy and trifluoromethyl; and R 6 and R 7 represent, independently of one another, either hydrogen, or C 1-6 alkyl optionally substituted by C 3-7 cycloalkyl, C 3-7 cycloalkenyl, C 1-3 alkoxy, phenyl, naphthalenyl, morpholinyl or pyridinyl; or C 3-7 cycloalkyl, C 1-6 alkoxy, phenyl or indanyl; the said C 3-7 cycloalkyl, C 3-7 cycloalkenyl, phenyl, naphthalenyl, morpholinyl, pyridinyl and indanyl groups being optionally substituted by one or two groups selected from C 1-3 alkyl, hydroxyl, C 1-3 alkoxy, phenyl or halogen; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form an aziridine, azetidine, pyrrolidine, piperidine, morpholine or benzopiperidine ring; or a pharmaceutically acceptable salt thereof.