Patent ID: 7019140

Claim:
A process for the synthesis of pergolide 1 comprising the following steps: a) reaction of 9,10-dihydrolysergic acid 6 with propyl iodide to give D-6-methyl-6-n-propyl-8(3-propyloxycarbonyl-6-ergolinium iodide 14; b) reduction of intermediate 14 to give D-6-methyl-6-n-propyl-8(3-hydroxymethyl-6-ergolinium iodide 12; c) demethylation of intermediate 12 with nucleophiles to give D-6-n-propyl-8(3-hydroxymethylergoline 4; d) reaction of D-6-n-propyl-8p-hydroxymethylergoline 4 with an alkylsulfonyl halide or a toluenesulfonyl halide RS02X, in which R is a straight or branched Cl—C alkyl chain, or a C6H5CH2 residue, whereas X is a halogen selected from fluorine, chlorine, bromine and iodine to give D-6-n-propyl-8p-alkylsulfonyloxymethylergoline or D-6-npropyl-8(3-tosyloxymethylergoline 5, in which R has the meanings defined above; e) reaction of compound of formula 5 with sodium thiomethoxide to give pergolide 1.