Patent ID: 7943610

Claim:
A compound of the Formula I: wherein: R 1 is selected from the group consisting of: —R 4 , —Y—R 4 , —X—N(R 8 )—Y—R 4 , —X—C(R 6 )—N(R 8 )—R 4 , —X—O—C(R 6 )—N(R 8 )—R 4 , —X—S(O) 2 —N(R 8 )—R 4 , —X—O—R 4 , and —X—R 5 ; R 1 ′ is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and hydroxyalkylenyl wherein the alkylenyl group contains at least two carbon atoms between the hydroxy or alkoxy substituent and the nitrogen atom to which R 1 ′ is bonded; or R 1 and R 1 ′ together with the nitrogen atom to which they are bonded can join to form a group selected from the group consisting of: A is selected from the group consisting of —CH(R 8 )—, —O—, —N(R 8 )—, —N(Y—R 4 )—, and —N(X—N(R 8 )—Y—R 4 )—; X is C 2-20 alkylene; Y is selected from the group consisting of —C(R 6 )—, —C(R 6 )—O—, —S(O) 2 —, —S(O) 2 —N(R 8 )—, and —C(R 6 )—N(R 11 )—; wherein R 11 is selected from the group consisting of hydrogen, alkyl, and arylalkylenyl; or R 11 and R 4 together with the nitrogen atom to which R 11 is bonded can join to form the group a and b are independently integers from 1 to 4 with the proviso that when A is —O—, —N(R 8 )—, —N(Y—R 4 )—, or —N(X—N(R 8 )—Y—R 4 )— then a and b are independently integers from 2 to 4; R A and R B are taken together to form a fused benzo ring unsubstituted or substituted by one or more R′ groups; R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, carboxy, formyl, aryl, aryloxy, arylalkoxy, heteroaryl, heteroaryloxy, heteroarylalkoxy, heterocyclyl, heterocyclylalkylenyl, amino, alkylamino, (arylalkylenyl)amino, dialkylamino, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo, with the proviso that when R 1 is R 4 , R 4 is a substituted alkyl group, and the substituent contains a hetero atom which bonds directly to the alkyl group, then the alkyl group contains at least two carbons between the substituent and the nitrogen atom to which R 1 is bonded; R 5 is selected from the group consisting of: R 6 is selected from the group consisting of ═O and ═S; R 7 is C 2-7 alkylene; R 8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, hydroxyalkylenyl, arylalkylenyl, and heteroarylalkylenyl; R 9 is selected from the group consisting of hydrogen and alkyl; R′ is a non-interfering substituent; and R″ is hydrogen or a non-interfering substituent; or a pharmaceutically acceptable salt thereof.