Patent ID: 7902349

Claim:
A purified nucleic acid comprising a nucleotide sequence encoding an immunogenic adenyl cyclase-haemolysin (AC-Hyl) polypeptide which induces the formation of antibodies when said nucleic acid or polypeptide is administered to a human or animal host, and wherein said nucleic acid is selected from the group consisting of: a) a nucleic acid comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence from amino acid 913 to the last C-terminal amino acid of SEQ ID NO:2, provided that the polypeptide does not include the amino acid residues 1-384 of SEQ ID NO:2; b) a nucleic acid encoding a polypeptide consisting of the amino acid sequence from amino acid 385 to amino acid 400 of SEQ ID NO:2; and c) a nucleic acid encoding a polypeptide consisting of the amino acid sequence from amino acid 385 to amino acid 500 of SEQ ID NO:2.