Patent ID: 7264792

Claim:
A process for the production of an 18 F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO 2 —O-TRACER (I) wherein the TRACER is of formula (A): wherein P 1 is hydroxy or a protecting group, P 2 and P 3 are independently hydrogen or a protecting group, R 1 is a bond, —CH═CH—, or together with R 2 forms R 3 ; R 2 is hydrogen or together with R 1 forms R 3 ; such that is formed wherein x is 0 or 1; y is 1 or 2; z is 1, 2, 3, or 4 and z>y if y is 2; q is 1 or 0 if n is 1 and j is 0; n is 1 or 2, but 0 if m is 0; m is 0 or 1; and j is 0 or 1; with 18 F − to produce the labelled tracer of formula (II) wherein R 1 , R 2 , y, z, P 1 , P 2 and P 3 are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18 F −, for example by ion-exchange chromatography; and/or (ii) removal of any protecting groups; and/or (iii) removal of organic solvent; and/or (iv) formulation of the resultant compound of formula (II) as an aqueous solution.