Patent ID: 8481738

Claim:
A compound having the following structure (I): and stereoisomers, and pharmaceutically acceptable salts thereof, wherein: A is naphthyridinyl or thienopyrimidinyl, wherein the thienopyrimidinyl is substituted with 0-5 R 4 ; R 1a is H, halogen, C 1-4 alkyl, alkoxy or trifluoromethyl; R 1b and R 1c are the same or different and are independently H, halogen, hydroxy, haloC 1-4 alkyl, —C 1-6 alkyl-(R 5 ) p , —O—C 1-6 alkyl-(R 5 ) p , —C 1-6 alkyl-O—C 1-6 alkyl-(R 5 ) p , —NR 7 —C 1-6 alkyl-(R 5 ) p , or —S(O) m —C 1-6 alkyl-(R 5 ) p ; R 1d is Cl, F, methyl, CF 3 or cyano; R 2 is —C 1-4 alkyl-(R 5 ) p ; R 2a is phenyl substituted with 0-4 R 3 , pyridyl substituted with 0-4 R 3 , C 1-6 alkyl substituted with 0-4 R 3 , aryl-C 1-4 alkyl substituted with 0-4 R 3 , or heteroaryl-C 1-4 alkyl substituted with 0-4 R 3 ; R 3 at each occurrence is independently halogen, cyano, halo-C 1-4 alkyl, R 5 , —C 1-6 alkyl-(R 5 ) p , —C 1-6 alkyl-O—C 1-6 alkyl-(R 5 ) p , —O—C 1-6 alkyl-(R 5 ) p , —NR 7 —C 1-6 alkyl-(R 5 ) p , —S(O) m —C 1-6 alkyl-(R 5 ) p , —O—C 1-6 alkyl-NR 7 —C 1-6 alkyl-(R 5 ) p , pyridyl-(R 5 ) p ; R 4 at each occurrence is independently halogen, C 1-6 alkyl, haloC 1-4 alkyl, C 1-6 alkoxy, hydroxy, cyano, thioC 1-6 alkyl, or —C(O)NR 7 R 8 ; R 5 at each occurrence is independently H, hydroxy, —OC(O)—C 1-6 alkyl, —OC(O)O—C 1-6 alkyl, —OC(O)—C 1-6 alkyl-NR 7 R 8 , —COOR 6 , —C(O)NR 7 R 8 , —NR 7 C(O)NR 7 R 8 , —S(O) 2 NR 9 R 9 , —S(O) m —C 1-4 alkyl, —NR 7 R 8 , C 1-6 alkoxy, —O-heterocycle, or pyridyl wherein said pyridyl and said —O-heterocycle are substituted with 0-4 groups selected from halogen, C 1-6 alkyl, C 1-4 haloalkyl, hydroxy, oxo, thio, —NH 2 , —S(O) 2 C 1-4 alkyl and —COOH; R 6 at each occurrence is independently H, C 1-4 alkyl, C 1-4 alkyl-O—C(O)—C 1-6 alkyl, or C 1-4 alkyl-O—C(O)—O—C 1-6 alkyl; R 7 at each occurrence is independently H, C 1-4 alkyl, hydroxy, or pyridyl where said pyridyl is substituted with 0-4 groups selected from halogen, C 1-6 alkyl, hydroxy, keto, —NH 2 and —COOH; R 8 at each occurrence is independently H, C 1-4 alkyl, haloC 1-4 alkyl, —C(O)—C 1-4 alkyl, —C(O)-haloC 1-4 alkyl, —S(O) m -haloC 1-4 alkyl or —S(O) m —C 1-4 alkyl; R 9 at each occurrence is independently H, C 1-4 alkyl, or —C(O)C 1-4 alkyl; m is 0-2; and p at each occurrence is independently 1-3.