Patent ID: 7335655

Claim:
A method of treating asthma, which method comprises administering to a patient in need of treatment thereof an effective amount of a compound of formula (I): wherein R 1 and R 2 are independently hydrogen, (C 1 to C 8 )alkyl, (C 2 to C 8 )alkenyl, (C 2 to C 8 )alkynyl, (C 7 to C 14 )aralkyl, (C 8 to C 14 )aralkenyl, or (C 8 to C 14 )aralkynyl; R 3 is hydrogen, (C 1 to C 4 )alkyl, (C 2 to C 5 )alkenyl, or (C 2 to C 5 )alkynyl; A is a carbon-carbon bond, alkyl chain of one to four carbons, alkenyl chain of two to four carbons, or alkynyl chain of two to four carbons; X is an optionally substituted five or six-membered heteroaromatic ring, containing one to four heteroatoms, selected from nitrogen, oxygen, or sulfur, provided that at least one heteroatom is nitrogen; M is a (C 1 to C 8 )alkylene, (C 2 to C 8 )alkenylene, or (C 2 to C 8 )alkynylene, wherein at least one of the carbon atoms of the alkylene, alkenylene, or alkynylene group is present as a carbonyl, and one or more of the remaining carbon atoms of the alkylene, alkenylene, or alkynylene group may be replaced by —O—, —N(R 7 )—, —S—, —S(O)—, or —S(O) 2 —; G 1 and G 2 are independently CH or N; R 4 , R 5 and R 6 are independently hydrogen, (C 1 to C 4 )alkyl, (C 2 to C 5 )alkenyl, (C 2 to C 5 )alkynyl, optionally substituted (C 6 to C 10 )aryl, (C 7 to C 14 )aralkyl, (C 8 to C 14 )aralkenyl, or (C 8 to C 14 )aralkynyl, acyl, optionally substituted alkoxy, aralkoxyalkylthio, amino, substituted amino, disubstituted amino, fluoro, chloro, bromo, iodo, nitro, cyano, azido, hydroxy, sulflhydryl, S(O)alkyl, S(O) 2 alkyl, CO 2 H, SO 3 H; or taken together with the carbon atoms to which they are attached either R 4 and R 5 or R 5 and R 6 form a five or six-membered heterocyclic or heteroaromatic ring containing one to four hetereoatoms selected from nitrogen, oxygen, or sulfur; or taken together with the carbon atoms to which they are attached either R 4 and R 5 or R 5 and R 6 form a carbocyclic or heterocyclic fused ring selected from the group of fused rings comprising —OCH 2 O—, —OCH(R 7 )O—, —OC(R 7 ) 2 O—, —OCH 2 CH 2 O—, —OCH 2 CH 2 —, —CH 2 CH 2 O—, —OCH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 O—, —OCH═CH—, —CH═CH—O—, —O—CH═CH—O—, —CH═CH—CH═CH—, —CH 2 CH 2 CH 2 — and —CH 2 CH 2 CH 2 CH 2 —; R 7 is hydrogen, (C 1 to C 4 )alkyl, (C 2 to C 5 )alkenyl, or (C 2 to C 5 )alkynyl; or a pharmaceutically acceptable salt thereof.