Patent ID: 7981611

Claim:
A method of up-regulating the gene expression of fibroblastic growth factor-2 (FGF-2 mRNA) or FGF-2 protein production in targeted tissue, comprising: generating at least one specific and selective signal having a frequency of approximately 60 kHz that when applied to one or more field generating devices operatively disposed with respect to said targeted tissue causes the generation of an electric and/or electromagnetic field having an amplitude of approximately 20 to 40 mV/cm in the targeted tissue that is specific and selective for the up-regulation of the gene expression of FGF-2 and/or the up-regulation of FGF-2 protein in the targeted tissue as measured by mRNA when said field is applied to the targeted tissue containing said FGF-2; and exposing said targeted tissue to the specific and selective field generated by said one or more field generating devices upon application of said at least one specific and selective signal thereto for a duration of approximately 24 hours per 24 hour period at a duty cycle between 50% and 100% so as to selectively up-regulate the gene expression of FGF-2 as measured by mRNA and/or up-regulate FGF-2 protein in said targeted tissue, wherein the generating step comprises the step of selectively varying the amplitude, duration, duty cycle, frequency, and waveform of the applied specific and selective signal until said at least one specific and selective signal is generated and said exposing step comprises exposing said targeted tissue to the specific and selective field until the gene expression of FGF-2 as measured by mRNA and/or FGF-2 protein in said targeted tissue as a result of exposure to the specific and selective field in the targeted tissue is increased.