Patent ID: 8691824

Claim:
At least one chemical entity chosen from compounds of Formula VI and pharmaceutically acceptable salts and prodrugs thereof wherein: R 1 is chosen from aryl and heteroaryl, each of which is substituted with one, two, or three groups chosen from halo, lower alkyl, lower alkoxy, optionally substituted amino, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, and hydroxy; R 2 and R 3 are independently chosen from hydrogen and lower alkyl; R 5 is chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; n is chosen from 1 and 2; and X is —C(O)O—; R 9 is chosen from hydrogen and lower alkyl provided that —R 1 is not 4-hydroxyphenyl.