Patent ID: 8399472

Claim:
A compound of formula III or a pharmaceutically acceptable salt thereof, wherein: X is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, substituted amino, carboxyl, carboxyl ester, halo, alkenyl, substituted alkenyl, alkynyl and substituted alkynyl; ring A is phenyl; p is 0, 1, 2 or 3; R is hydrogen; each R 2 independently is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cycloalkyl, substituted cycloalkyl, cycloalkoxy, substituted cycloalkoxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, nitro and halo; Z 1 , Z 2 , and Z 3 are carbon; q is 0, 1, 2 or 3; each R 3 independently is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, halo, heterocyclic and substituted heterocyclic; R 4 and R 5 independently are selected from the group consisting of hydrogen, alkyl, substituted alkyl, acyl and M + , wherein M + is a metal counterion selected from the group consisting of K + , Na + , Li + or + N(R 6 ) 4 , wherein R 6 is hydrogen or alkyl, and the nitrogen of SO 2 NR 4 R 5 is N − ; or R 4 or R 5 is a divalent counterion selected from the group consisting of Ca 2+ , Mg 2+ , and Ba 2+ , and the nitrogen of SO 2 NR 4 R 5 is N − ; or R 4 and R 5 together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; SO 2 NR 4 R 5 is meta to the amino group at the 2 position of the pyrimidine; and provided that: if p=0, then X is not bromo; if p=2 and each of R 2 is methoxy, halo, trihalomethyl or trihalomethoxy, then R 4 and R 5 are not one hydrogen and one methyl; if p=2 and R 2 is fluoro and methyl, then R is not substituted alkenyl; and if p=1 and R 2 is chloro, then R 4 and R 5 are not one hydrogen and one methyl.