Patent ID: 8580748

Claim:
A method of treating noise-induced hearing loss, the method comprising administering to a subject in need or want of relief thereof a therapeutically-effective amount of a peptide that is: a peptide of Formula (I) or Formula (II), (cap N )(cap N )N-tran N -pep N -(X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 ) x -pep C -tran C -C(O)-cap C Formula (I), (cap N )(cap N )N-tran N -pep N -(X 12 -X 11 -X 10 -X 9 -X 8 -X 7 -X 6 -X 5 -X 4 -X 3 -X 2 -X 1 ) x -pep C -tran C -C(O)-cap C Formula (II), wherein each cap N is independently H, alkyl, aryl, aralkyl, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, or an aminocarbonyl group, or both cap N groups together with N form a heterocycle; tran N and tran C are each independently a transducing sequence or absent; pep N and pep C are each independently an amino acid sequence or absent; X 1 is A, K, an acidic amino acid residue, or is absent; X 2 is A, I, L, or V; X 3 is A, D, I, L, P, or V; X 4 is A, E, I, Y, or a basic amino acid residue; X 5 is A, I, L, or V; X 6 is A, G, S, T, or Y; X 7 is A, E, I, L, or V; X 8 is A, P, S, T, or an aromatic amino acid residue; X 9 is A, K, or an acidic amino acid residue; X 10 is A, C, M, S, α-aminobutyric acid, or norvaline; X 11 is A, I, L, V, or is absent; X 12 is G or is absent; x is 1, 2, or 3; cap C is OH, alkoxy, aryloxy, arylalkoxy, amino, alkylamino, dialkylamino, or a heterocycle; and each amino acid residue side chain is independently uncapped or capped with a capping group, or a stereoisomer or pharmaceutically-acceptable salt of any of the foregoing peptides, wherein the amino acid sequence of the peptide is not SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID NO: 186, SEQ ID NO: 369, or SEQ ID NO: 378.