Patent ID: 8106194

Claim:
A compound represented by the following formula [I]: (wherein E is N or CR 10 ; R 1 is —OR 4 , —S(O) 1 R 4 or —NR 4 R 5 ; R 2 is C 1-6 alkyl; R 3 is hydrogen; R 4 and R 5 are the same or different, and independently hydrogen, C 1-9 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, di(C 3-7 cycloalkyl)-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, di(C 1-6 alkoxy)-C 1-6 alkyl, hydroxy-C 1-6 alkyl, cyano-C 1-6 alkyl, carbamoyl-C 1-6 alkyl or di(C 1-6 alkyl)amino-C 2-6 alkyl; or R 4 and R 5 are taken together to form —(CH 2 ) m -A-(CH 2 ) n — wherein A is CHR 9 ; R 9 is hydrogen, hydroxy, hydroxy-C 1-6 alkyl, cyano or cyano-C 1-6 alkyl; R 10 is hydrogen; l is an integer selected from 0, 1 and 2; m is an integer selected from 1, 2, 3 and 4; n is an integer selected from 0, 1, 2 and 3; Ar is phenyl which phenyl is substituted with 1 or more substituents, which are the same or different, selected from the group consisting of halogen, C 1-6 alkyl, and trifluoromethyl; or pharmaceutically acceptable salts thereof.