Patent ID: 8182463

Claim:
A method comprising: positioning a catheter into a blood vessel; and locally administering a therapeutic agent to the blood vessel through the catheter in a direction opposite blood flow; wherein said agent is administered by the catheter, the catheter comprising: a shaft comprising a proximal end and a distal end, and defining a delivery lumen through a portion thereof, the delivery lumen comprising a proximal end and a distal end; a delivery port coupled to the distal end of the delivery lumen; a pressure monitoring lumen, a portion of the pressure monitoring lumen disposed within the shaft, comprising a proximal end and a distal end; a pressure port coupled to the distal end of the pressure monitoring lumen; a balloon inflation lumen, a portion of the balloon inflation lumen disposed within the shaft, comprising a proximal end and a distal end; a low-pressure high-compliance balloon adjacent to the distal end of the flexible shaft, the balloon comprising at least one material selected from the group consisting of polyether block amide resins, blends of polyether block amide resins, a composite including an elastomeric material and EPTFE, a styrene-isoprene-styrene tri-Block co-polymer, and blends and mixtures thereof; wherein, prior to administering, inflating the balloon to a diameter that is at least 40% of a maximum outer diameter of the balloon at a pre-determined gauge pressure of about 0.5 to about 6.0 atmospheres and once it is determined that a venous pressure waveform within the vessel is ventricularized, administering the therapeutic agent to the vessel such that the vessel remains occluded during administering.