Patent ID: 7071204

Claim:
A camptothecin analog having the structure: where X and Y are each independently SH, S—C 1-6 alkyl, NH—C 1-6 alkyl, CHO, N 3 , —Z—(CH 2 ) a —N—((CH 2 ) b OH) 2 , wherein Z is selected from the group consisting of O, NH and S, and a and b are each independently an integer of 2 or 3, —Z—(CH 2 ) a —N—(C 1-6 alkyl) 2 wherein Z is selected from the group consisting of O, NH and S, and a is an integer of 2 or 3, or —CH 2 -L, where L is halogen, + N 2 , + (OR 1 ) 2 , + S(R 1 ) 2 , + N(R 1 ) 3 , OC(O)R 1 , OSO 2 R 1 , OSO 2 CF 3 , OSO 2 C 4 F 9 , C 1-6 alkyl-C(═O)—, C 4-18 aryl-C(═O)—, C 1-6 alkyl-SO 2 —, perfluoro C 1-6 alkyl-SO 2 — or C 4-18 aryl-SO 2 —, (where each R 1 independently is C 1-6 alkyl, C 4-18 aryl or C 4-18 ArC 1-6 alkyl); R 7 is H; and R 13 and R 14 are each H or combine to form a double bond; and salts thereof.