Patent ID: 6930108

Claim:
A method for the treatment of, psoriasis, female infertility, diabetes, ophthalmic disorders, glaucoma, disorders of gastric motility, cystic fibrosis, premature labour, pulmonary hypertension, nitrate-induced tolerance, pre-eclampsia, alopecia, Parkinson's disease, pain, tinnitus or the renal syndrome comprising administering to a subject in need thereof an effective amount of one or more 2-phenyl-substituted imidazotriazinones of the general formula (I) in which R 1 represents methyl or ethyl, R 2 represents ethyl or propyl, R 3 and R 4 are identical or different and represent a straight-chain or branched alkyl chain having up to 5 carbon atoms, which is optionally up to disubstituted identically or differently by hydroxyl or methoxy, or R 3 and R 4 together with the nitrogen atom form a piperidinyl ring, morpholinyl ring, thio-morpholinyl ring or a radical of the formula in which R 5 denotes hydrogen, formyl, acyl or alkoxycarbonyl in each case having up to 3 carbon atoms, or denotes straight-chain or branched alkyl having up to 3 carbon atoms, which is optionally mono- to disubstituted, identically or differently, by hydroxyl, carboxyl, straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 3 carbon atoms or by groups of the formula —(D) a- NR 6 R 7 or —P(O)(OR 8 )(OR 9 ), in which a denotes a number 0 or 1, D denotes a group of the formula —CO, R 6 and R 7 are identical or different and denote hydrogen or methyl, R 8 and R 9 are identical or different and denote hydrogen, methyl or ethyl, or R 5 denotes cyclopentyl, and the heterocycles mentioned under R 3 and R 4 , formed together with the nitrogen atom, are optionally mono- to disubstituted, identically or differently, optionally also geminally, by hydroxyl, formyl, carboxyl, acyl or alkoxycarbonyl in each case having up to 3 carbon atoms or groups of the formula —P(O)(OR 10 )(OR 11 ) or —(CO) b NR 12 R 13 , in which R 10 and R 11 are identical or different and denote hydrogen, methyl or ethyl, b denotes a number 0 or 1, and R 12 and R 13 are identical or different and denote hydrogen or methyl and/or the heterocycles mentioned under R 3 and R 4 , formed together with the nitrogen atom, are optionally substituted by straight-chain or branched alkyl having up to 3 carbon atoms, which is optionally mono- to disubstituted, identically or differently, by hydroxyl, carboxyl or by a radical of the formula P(O)OR 14 OR 15 , in which R 14 and R 15 are identical or different and denote hydrogen, methyl or ethyl, and/or the heterocycles mentioned under R 3 and R 4 , formed together with the nitrogen atom, are optionally substituted by piperidinyl or pyrrolidinyl linked via N, and R 16 represents ethoxy or propoxy, and their salts, hydrates and/or solvates.