Patent ID: 8377480

Claim:
A non-coated, sustained release pharmaceutical composition consisting of a plurality of granules, the granules consisting of: (i) about 10% to about 60% by weight of a non-coated complex particulate consisting of styrene-divinylbenzene sulfonic acid cationic exchange resin particles and different pharmaceutically active materials complexed with the ion exchange resin particles, the pharmaceutically active materials being selected from the group consisting of oxycodone hydrochloride, tramadol hydrochloride, dextromethorphan, hydrocodone bitartrate, chlorpheniramine maleate, codeine, morphine or morphine salt, hydrocodone, phenylpropanolamine, pseudoephedrine, dihydrocodeine, methylephedrine, ephedrin, paramino salicylic acid, phentermine, pilocarpine, metoclopramide and theophylline, wherein each of the different pharmaceutically active materials is complexed with different ion exchange resin particles; and, (ii) a non-coated, granulated water-insoluble matrix consisting of microcrystalline cellulose, wherein the non-coated, complex particulate is embedded into the non-coated, granulated water-insoluble matrix of microcrystalline cellulose, and further wherein the non-coated, granulated water-insoluble matrix of microcrystalline cellulose sustains release of the different pharmaceutically active materials from the non-coated, complex particulate.