Patent ID: 8399422

Claim:
Compositions of transfection comprising an oligonucleotide active for gene silencing and an amphiphilic cationic molecule of formula (I) (I) wherein X is N—R 1 , R 1 being a C1-C4 alkyl radical or an hydroxylated C3-C8 alkyl radical, R 2 and R 3 , identical or different, represent H or a C1-C4 alkyl radical, or R 2 and R 3 are linked together to form a saturated or unsaturated cycle or a heterocycle having 5 or 6 elements, E is a C1-C5 alkyl spacer, R 4 and R 5 , identical or different, represent saturated or unsaturated, linear or branched, C10-C36 hydrocarbon or fluorocarbon chains, A − is a biocompatible anion.