Patent ID: 7232815

Claim:
A compound of the formula I wherein X is O, S, S(═O), S(═O) 2 , or NR a , wherein R a is hydrogen or a protecting group; Y and Z are each independently hydrogen, halogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl, C 2 –C 4 alkynyl, halo-C 1 –C 4 alkyl, hydroxy, C 1 –C 4 alkoxy, trifluoromethyl, trifluoromethoxy, C 1 –C 4 alkanoyl, amino, amino-C 1 –C 4 alkyl, N—(C 1 –C 4 alkyl)amino, N,N-di(C 1 –C 4 -alkyl)amino, thiol, C 1 –C 4 alkylthio, sulfonyl, C 1 –C 4 alkylsulfonyl, sulfinyl, C 1 –C 4 alkylsulfinyl, carboxy, C 1 –C 4 alkoxycarbonyl, cyano or nitro; R 1 is hydrogen, C 1 –C 7 alkyl, CHO, (CH 2 ) 2 COOH, (CH 2 ) 2 CO 2 Et, (CH 2 ) m L, wherein m is 1 or 3 and L is OH or Br; or a substituent of the formula II wherein R 2 and R 3 are each independently hydrogen, C 1 –C 4 alkyl, aryl or R 2 and R 3 taken together with the nitrogen atom to which they are attached are an optionally substituted heterocycle or heteroaryl; m is integer from 1 to 3; n is integer from 0 to 3; Q 1 and Q 2 are each independently oxygen, sulphur wherein y 1 and y 2 are each independently hydrogen, halogen, C 1 –C 4 alkyl or aryl, hydroxy, C 1 –C 4 alkoxy, C 1 –C 4 alkanoyl, thiol, C 1 –C 4 alkylthio, sulfonyl, C 1 –C 4 alkylsulfonyl, sulfinyl, C 1 –C 4 alkylsulfinyl, cyano, nitro or y 1 and y 2 taken together with the carbon or nitrogen atom to which they are attached form a carbonyl group or an imino group; and a pharmacologically acceptable salt or solvate salt thereof, wherein an optionally substituted heteroaryl or heterocycle is a heteroaryl or heterocyclic group, which is substituted with one or two substituents, selected from the group consisting of halogen, C 1 –C 4 alkyl, cyano, nitro, hydroxy, C 1 –C 4 alkoxy, thiol, C 1 –C 4 alkylthio, amino, N—(C 1 –C 4 ) alkylamino, N,N-di(C 1 –C 4 -alkyl)-amino, sulfonyl, C 1 –C 4 alkylsulfonyl, sulfinyl, and C 1 –C 4 alkylsulfinyl.