Patent ID: 8124050

Claim:
A method of coating the internal surface of a device with a polymer, wherein the device is a microfabricated device or a reaction vessel with an internal diameter of less than about 2 mm, the method comprising the steps of: (i) introducing into the device a solution of one or more monomers in a suitable solvent; (ii) introducing a flow of an inert gas through the device; and (iii) initiating polymerisation of the monomer solution; wherein polymerisation of the one or more monomers leads to a ROMP polymer of Formula (I): wherein: X is either a C 4-6 cycloalkyl or C 4-6 heterocyclyl moiety; L is a C 1 to C 20 linker group comprising one or more alkyl, alkenyl, alkynyl, C 4-10 cycloalkyl, C 4-10 heterocyclyl, C 4-10 aryl, C 4-10 heteroaryl, ether, PEG, sulphide, amide, sulphamide or a combination thereof; any of which may be substituted with one or more groups R 2 R 1 is hydrogen, C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, C 4-12 cycloalkyl, C 4-12 heterocyclyl, aryl, heteroaryl, C(O)R 3 , C 1-20 alkyl-C(O)R 3 , C 2-20 alkenyl-C(O)R 3 , C 2-20 alkynyl-C(O)R 3 , nitro, isocyanate, C 1-10 alkyl-C(O)—C(R 4 ) 2 -C(O)—C 1-10 alkyl, aminooxy, nitrile, phosphorus chloride, succinimide, sulphonyl chloride, halogen, tosylate, mesylate, triflate, nonaflate, silane, OR 4 , SR 4 , N(R 4 ) 2 , N + (R 4 ) 3 , quaternary phosphorous, C 1-20 alkyl-R 5 , C 2-20 alkenyl-R 5 or C 2-20 alkynyl-R 5 or a group comprising an enzyme or a catalyst; R 2 is C(O)R 3 , C 1-20 alkyl-C(O)R 3 , C 2-20 alkenyl-C(O)R 3 , C 2-20 alkynyl-C(O)R 3 , nitro, isocyanate, C 1-10 alkyl-C(O)—C(R 4 ) 2 -C(O)—C 1-10 alkyl, aminooxy, nitrile, phosphorus chloride, succinimide, sulphonyl chloride, halogen, tosylate, mesylate, triflate, nonaflate, silane, OR 4 , SR 4 , N(R 4 ) 2 , N + (R 4 ) 3 , quaternary phosphorous, C 1-20 alkyl-R 5 , C 2-20 alkenyl-R 5 or C 2-20 alkynyl-R 5 ; R 3 is H, OH, C 1-20 alkyl, OC 1-20 alkyl, N(R 4 ) 2 , N + (R 4 ) 3 ; each R 4 is independently H or C 1-10 alkyl; R 5 is OR 4 , SR 4 , N(R 4 ) 2 , N + (R 4 ) 3 , C 4-10 cycloalkyl, C 4-10 heterocyclyl, aryl or heteroaryl.