Patent ID: 8741910

Claim:
A compound having structural Formula I, or a pharmaceutically acceptable salt thereof: wherein: is an 8- or 9-membered heteroaryl; R a and R b are independently selected at each occurrence from the group consisting of —H and —C 1 -C 6 alkyl; R c is independently selected at each occurrence from the group consisting of —C 1 -C 6 alkyl, —CF 3 , and aryl; R 1 is independently selected at each occurrence from the group consisting of —H, halo, aryl, heteroaryl, —C 1 -C 6 alkyl, —C 3-10 cycloalkyl, —OR, —NO 2 , —CN, —CO 2 R a , —NR a R b , —S(O) p R c , thioxo, azido, —C(═O)R a , —OC(O)R a , —OC(═O)OR a , —OC(═O)NR a R b , —SO 2 NR a NR b , —NR a (C═O)R b , —NR a SO 2 R b , —NR a C(═O)OR b , —NR a C(O)NR a R b , —NR a SO 2 NR a R b , —C 2-10 alkenyl, and —C 2-10 alkynyl, said aryl, heteroaryl, alkyl, cycloalkyl, alkenyl and alkynyl optionally being substituted with one to three substituents selected from halo, —C 1 -C 6 alkyl, —OR, oxo, aryl, heteroaryl, —C 3-10 cycloalkyl, —NO 2 , —CN, CO 2 R a , NR a R b , —S(O) p R c , thioxo, azido, —C(═O)R a , —O(C═O)R a , —OC(═O)OR a , —OC(═O)NR a R b , —SO 2 NR a NR b , —NR a (C═O)R b , —NRaSO 2 R b , —NR a C(═O)OR b , —NR a C(═O)NR a R b , —NR a SO 2 NR a R b and —CF 3 ; R 2 is selected from the group consisting of —C 1 -C 6 alkyl, —(CR a 2 ) r OR, —(CR a 2 ) r S(O) p R c , —(CR a 2 ) r CF 3 , —(CR a 2 ) r —C 3-10 cycloalkyl, —(CR a 2 ) r aryl, —(CR a 2 ) r heteroaryl, —(CR a 2 ) r —C 2-10 alkenyl, —(CR a 2 ) r —C 2-10 alkynyl, and —(CR a 2 ) r C(O)Oalkyl, said alkyl, cycloalkyl, aryl, hetetoaryl, alkenyl and alkynyl being optionally substituted with one to three substituents selected from halo, —C 1 -C 6 alkyl, —CF 3 , —CN and —OR; R is independently selected at each occurrence from the group consisting of —H, —C 1 -C 6 alkyl, —CF 3 , and aryl; R 3 and R 4 are independently selected from the group consisting of —H and —C 1 -C 6 alkyl; when R 3 and R 4 are C 1 -C 6 alkyl they may optionally be joined to form a cycloalkyl; m is 0, 1, 2, or 3; p is 0, 1 or 2; r is 0, 1, 2, 3, 4, 5, or 6; and z is 0 or 1.