Patent ID: 8603974

Claim:
A biologically active salmon follitropin glycoprotein hormone analog, capable of binding to a follicle stimulating hormone receptor, said analog consisting essentially of a heterodimer comprising a glycosylated α subunit polypeptide and a glycosylated β subunit polypeptide, wherein: said α subunit polypeptide comprising the sequence set forth in SEQ ID NO: 66; said β subunit polypeptide comprising the sequence set forth in SEQ ID NO: 53; said α subunit polypeptide and β subunit polypeptide are linked by a peptide bond; said β subunit polypeptide comprises a seatbelt region that wraps around said alpha α subunit polypeptide; said α and β subunit polypeptides are covalently linked via two disulfide bonds consisting of a first disulfide bond and a second disulfide bond; said first disulfide bond is between cys29 of said α subunit polypeptide and a cysteine residue on the N-terminus end of said β subunit polypeptide; and said second disulfide bond is between cys110 of said α subunit polypeptide and cys98 of said β subunit polypeptide.