Patent ID: 8758448

Claim:
An article for wound healing and tissue regeneration, comprising: a first sheet comprising a first mammalian extracellular matrix and a second sheet comprising a second mammalian extracellular matrix, said first and second extracellular matrices comprising small intestine submucosa, said first extracellular matrix sheet having a first outer edge, said second extracellular matrix sheet having a second outer edge, said first and second extracellular matrix sheets being laminated to each other proximate said first and second edges to form a laminated article having a cavity therein, said article further comprising an extracellular matrix composition comprising a third extracellular matrix comprising liver basement membrane, a fourth extracellular matrix comprising urinary bladder submucosa, a cell comprising a mesenchymal stem cell and a protein comprising a growth factor, said growth factor comprising fibroblast growth factor-2 (FGF-2) vascular epithelial growth factor (VEGF), and said extracellular matrix composition being disposed in said article cavity.