Patent ID: 7053110

Claim:
A compound of the structure including pharmaceutically acceptable salts thereof, and all stereoisomers thereof, wherein R 1 is alkyl, aryl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, arylalkyloxyalkyl, aryloxyalkyl, or cycloalkylalkoxyalkyl, and these groups may be optionally substituted by 1,2 or 3-substituents selected from halogen, —OR 8 , —OC(O)R 8 , alkyl, phenyl, phenoxy, halophenyl, —CF 3 , —OCF 3 , —N(R 8a )C(O)(R 8 ), or —N(R 8 )(R 8a ); R 1a is H, alkyl, or cycloalkyl; X a is heteroaryl, which is R 5 is H, alkyl, aryl, alkenyl, arylalkenyl, alkynyl, arylalkyl, arylalkynyl, cycloalkylalkyl, alkoxyalkyl, aryloxyalkyl, arylalkyloxyalkyl, cycloalkylalkoxyalkyl, —SO 2 T 1 , or —SO 2 N(T 1a )T 1 , and where alkyl, aryl, alkenyl, arylalkenyl, alkynyl, arylalkyl, arylalkynyl, cycloalkylalkyl, alkoxyalkyl, aryloxyalkyl, arylalkyloxyalkyl, or cycloalkylalkoxyalkyl, may be independently optionally substituted with 1 to 3 J1; Y is where x and y are independently 0 to 3; X c is a bond; R 7 and R 7a are the same or different and are independently selected from H, alkyl, —CF 3 , phenyl, aryl, and cycloalkyl; R 6 , are the same or different and are independently H, alkyl, cycloalkyl, alkenyl or aryl; X b is R 9 and R 10 are the same or different and are independently selected from H, alkyl, and substituted alkyl where the substituents may be 1 to 3 hydroxy, 1 to 3 C 1 –C 10 -alkanoyloxy, 1 to 3 C 1-6 alkoxy, phenyl, phenoxy or C 1 –C 6 -alkoxycarbonyl; J1 is nitro, —(CH 2 )vN(T 1a )C(O)T 1 , —(CH 2 ) v CN, —(CH 2 ) v N(T 1a )C(O)OT 1 , —(CH 2 ) v N(T 1a )C(O)N(T 1b )T 1 , —(CH 2 ) v N(T 1a )SO 2 T 1 , —(CH 2 ) v C(O)N(T 1a )T 1 , —(CH 2 ) v C(O)OT 1 , —(CH 2 ) v OC(O)OT 1 , —(CH 2 ) v OC(O)T 1 , —(CH 2 ) v OC(O)N(T 1a )T 1 , —(CH 2 ) v N(T 1a )SO 2 N(T 1b )T 1 , —(CH 2 ) v OT 1 , —(CH 2 ) v SO 2 T 1 , —(CH 2 )vSO 2 N(T 1a )T 1 , —(CH 2 )vC(O)T 1 or —(CH 2 )vCH(OH)T 1 , with v being 0–5; T 1 , T 1a and T 1b are the same or different and are independently H, alkyl, alkenyl, alkynyl, lower alkythioalkyl, alkoxyalkyl, aryl, arylalkyl or cycloalkyl, each of which may be optionally substituted with 1, 2 or 3 substituents selected from halogen, hydroxyl, —NR 8f C(O)NR 8g R 8i , —C(O)NR 8f R 8g , —NR 8f C(O)R 8g , —CN, —N(R 8f )SO 2 R 14 , —OC(O)R 8f , —SO 2 NR 8f R 8g , —SOR 14 , —SO 2 R 14 , alkoxy, —COOH or —C(O)OR 14 ; with the proviso that T 1 can not be hydrogen when it is connected to carbonyl or sulfur, as in —C(O)T 1 or —SO 2 T 1 ; are independently C 1 –C 6 alkyl or aryl, each optionally substituted with —(CH 2 ) s OH, with s being 0–5.