Patent ID: 8168225

Claim:
A method of continuous microencapsulation or multi-microencapsulation of biologically active materials by means of in situ interfacial polymerization under continuous agitation wherein the method comprises: forming a water in oil emulsion comprising a water phase, an oil phase, a polymerization initiator, an emulsifier and at least one biologically active ingredient(s), wherein: the polymerization initiator exists in the water phase, the emulsifier exists in the oil phase or in the water phase, the biologically active ingredient(s) exists in the oil phase and/or in the water phase; adding an aqueous solution or dispersion containing at least one hydrocolloid(s) which is polymerizable due to the polymerization initiator and thereby producing a phase inversion whereby there are drops of water in oil and polymerization and cross-linking of the hydrocolloid(s) onto the drops of water in oil; adding an aqueous solution or dispersion containing at least one protective colloid(s) and thereby depositing the protective colloid(s) on the surface of the drops of water in oil, whereby the protective colloid(s) polymerizes and cross-links with itself and the hydrocolloid(s); adding an aqueous solution or dispersion containing a surfactant and thereby reducing the size of the water in oil drops, whereby microcapsules or multi-microcapsules having a wall and suspended in water result; and subjecting the microcapsules or multi-microcapsules having a wall and suspended in water to a temperature increase to strengthen the wall.