Patent ID: 7897595

Claim:
A compound of formula I: wherein R 1 , R 1a , R 4 and R 4a are each independently hydrogen, hydroxyl, alkyl, alkenyl, aryl, alkoxy, aryloxy, amino, alkylamino or arylamino; R 2 , R 2a , R 3 and R 3a are each independently hydrogen or alkyl; or R 1 and R 1a or R 2 and R 2a or R 3 and R 3a or R 4 and R 4a , together with the carbon atom to which they are attached, independently form a C═O or C═CRR′ group where R and R′ are independently hydrogen or alkyl; R 5 and R 6 are each independently hydrogen, halogen, hydroxyl, alkyl, alkenyl, aryl, arylalkyl, alkoxy, alkenyloxy, aryloxy, nitro, amino, alkylamino, dialkylamino, arylamino, diarylamino or —C(O)OR 8 in which R 8 is hydrogen, alkyl or aryl; R 7 is hydrogen, —C(O)R 9 , —C(O)OR 9 , C(O)NR 9 R 10 , —S(O) 2 R 11 or —S(O)R 11 , in which R 9 and R 10 are each independently hydrogen, halogen, alkyl or aryl and R 11 is alkyl or aryl; X 1 and X 2 are independently N, or CR 12 in which R 12 is hydrogen, halogen, hydroxyl, alkoxy, alkyl, or alkenyl, with the proviso that when X 1 is N, then X 2 is CR 12 and when X 2 is N, then X 1 is CR 12 , and pharmaceutically acceptable salts thereof; with the proviso that said compound is not: 6,7,8,9-tetrahydro-2,3-diphenyl-5H-Pyrido [2,3-d] azepine, 2-amino-5,6,8,9-tetrahydro-7H-Pyrido [2,3-d]azepine-7- carboxylic acid 1,1-dimethylethyl ester, 6,7,8,9-tetrahydro-5H-Pyrido[2,3-d]azepin-2-amine, 5,6,8,9-tetrahydro-7H-Pyrido[2,3-d]azepine-3,7-dicarboxylic acid diethyl ester, 1,2,5,6,8,9-hexahydro-2-oxo-7H-Pyrido[2,3-d]azepine-7-carboxylic acid ethyl ester, 1,2,5,6,8,9-hexahydro-2-oxo-7H-Pyrido[2,3-d]azepine-3,7-dicarboxylic acid diethyl ester, 4-chloro-1,2,5,6,8,9-hexahydro-2-oxo-7H-Pyrido[2,3-d]azepine-7-carboxylic acid ethyl ester, 4-chloro-1,2,5,6,8,9-hexahydro-2-oxo-7H-Pyrido[2,3-d]azepine-3,7-dicarboxylic acid diethyl ester, 2,4-dichloro-5,6,8,9-tetrahydro-7H-Pyrido[2,3-d]azepine-3,7-dicarboxylic acid diethyl ester, 1,2,5,6,8,9-hexahydro-4-hydroxy-2-oxo-7H-Pyrido[2,3-d]azepine-7-carboxylic acid ethyl ester, or 1,2,5,6,8,9-hexahydro-4-hydroxy-2-oxo-7H-Pyrido[2,3-d]azepine-3,7-dicarboxylic acid diethyl ester.