Patent ID: 8492430

Claim:
A method for the prophylaxis or treatment of diabetes comprising administering to a mammal in need thereof a therapeutically effective amount of (a) a compound represented by the formula (I): wherein R 1 is R 6 —SO 2 — (wherein R 6 is a substituent) or an optionally substituted 1,1-dioxidotetrahydrothiopyranyl group; X is a bond or a divalent hydrocarbon group; R 2 and R 3 are the same or different and each is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an optionally substituted hydroxy group; R 4 and R 5 are the same or different and each is a C 1-6 alkyl group optionally substituted by hydroxy group(s); ring A is a benzene ring optionally further having substituent(s) selected from the group consisting of a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxy group and an optionally substituted amino group; ring B is a 5- to 7-membered ring; Y is a bond or CH 2 ; and R is an optionally substituted hydroxy group, or a salt thereof; in combination with (b) another pharmaceutically active ingredient.