Patent ID: RE43793

Claim:
An endosseous implant suitable for application to a human or animal bone, said implant having a surface made from titanium or a titanium alloy, said surface having a smooth or rough texture, wherein said surface has a layer formed thereon of at least one pharmaceutically acceptable organic compound or an ester , an amide or a salt thereof, corresponding to the general formula (I): A-[P(O)(OH) 2 ] p (I), wherein A means A 1 , and A 1 is a residue of a linear, branched or cyclic, saturated or unsaturated, hydrocarbon residue with n carbon atoms, wherein n is a number from 1 to 70, whereby said residue is not interrupted or is interrupted by one or more oxygen and/or nitrogen atoms, wherein each residue A 1 carries p phosphonic acid groups, and when n is 1 and p is 2: A is —CH 2 —, or when n is 1: p is 3 or 4, or when n is 2 to 10: p is 2, provided each phosphonic acid group or phosphonic acid ester group is bound to a different carbon atom within the same molecule; or when n is 2 to 10: p is 3, 4, 5 or 6; or when n is 11 to 70: p is 2, 3, 4, 5 or 6; or A means A 2 and A 2 is a residue of an amino acid or of a sequence of amino acids respectively of a protein or of a polypeptide; or a residue of a specific drug molecule, wherein each residue A 2 carries p phosphonic acid groups, and p is 1 to 6 when A 2 is a residue of an amino acid or of a sequence of amino acids respectively of a protein or of a polypeptide; or p is 1 or 3-6 when A 2 is a residue of a specific drug molecule originally not bearing any phosphonate group, optionally falling under the definition given for A 1 .