Patent ID: 8846640

Claim:
A biomaterial for use as a filler and/or as a body shaping product prepared by a process comprising: (a1) mixing an autocrosslinked hyaluronic acid (ACP) powder with (HBC) a hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (HBC) in a weight ratio of between 10:90 and 90:10, wherein the hyaluronic acid in said ACP and HBC has a mean molecular weight of between 200,000 and 1×10 6 Da; (b1) hydrating with saline solution or phosphate buffer, leading to a total hyaluronic acid concentration of between 12 and 27 mg/ml; (c1) extruding at a temperature of between 25 and 65° C. through a sieve with a mesh of between 50 and 500 □m; and (d1) sterilizing by heat from saturated steam at a temperature of between 120 and 124° C. for at least 10 min; or (a2) mixing an autocrosslinked hyaluronic acid (ACP) gel or powder with a hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (HBC) in gel form in a weight ratio of between 10:90 and 90:10; (b2) crushing and homogenizing by passing through a filter with a particulate matter retention coefficient of between 25 and 150 μm; and (c2) sterilizing by heat from saturated steam at a temperature of between 120 and 124° C. for at least 10 min.