Patent ID: 8637263

Claim:
A method for screening candidate compounds, comprising the steps of: contacting one or more candidate compounds with a 5-HT 1a receptor and determining the binding affinity and compound efficacy of the candidate compounds with respect to binding of the 5-HT 1a receptor; contacting one or more candidate compounds with a 5-HT 1d receptor and determining the binding affinity and compound efficacy of the candidate compounds with respect to binding of the 5-HT 1d receptor; contacting one or more candidate compounds with a 5-HT 7 receptor and determining the binding affinity and compound efficacy of the candidate compounds for the 5-HT 7 receptor; selecting a candidate compound, wherein the selected candidate compound is an agonist of at least one of the 5-HT 1a receptor and the 5-HT 1d receptor, wherein the selected candidate compound is an antagonist of the 5-HT 7 receptor, and wherein the candidate compound has an EC50 value for the 5-HT 7 receptor of greater than 10 μM; and treating a subject for emesis by administering the selected candidate compound to the subject.