Patent ID: 8883506

Claim:
A kit for making synthetic mRNAs for the production of induced pluripotent stem (iPS) cells comprising the following components: (a) a linear DNA template for the generation of a synthetic modified RNA, the template encoding an OCT4 mRNA of SEQ ID NO: 788; (b) a linear DNA template for the generation of a synthetic modified RNA, the template encoding a SOX2 mRNA of SEQ ID NO: 941 or SEQ ID NO: 1501; (c) a linear DNA template for the generation of a synthetic modified RNA, the template encoding a KLF4 mRNA of SEQ ID NO: 501; (d) a linear DNA template for the generation of a synthetic modified RNA, the template encoding a c-MYC mRNA of SEQ ID NO: 636; and (e) a ribonucleoside mixture component comprising 5-methylcytidine and pseudouridine.