Patent ID: 8877706

Claim:
A compound of Formula I or I-1: or a salt thereof, wherein X is hydrogen or halo; Y is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, and —C(═O)R 5 ; R 1 is selected from the group consisting of hydrogen, —OH, —OC(═O)R 5 and —OR 5 ; R 2 is hydrogen or C 1 -C 6 alkyl; R 3 is methyl, —CH 2 OH, or —CH 2 C(═O)R 6 ; R 4 is —OH or —SH; R 5 is C 1 -C 6 alkyl or benzyl; R 6 is C 1 -C 6 alkyl, phenyl or benzyl; R 7 is hydrogen, C 1 -C 6 alkyl or an amino acid side chain; R 8 is hydrogen or C 1 -C 6 alkyl; each Z is independently hydrogen or C 1 -C 4 alkyl, or the two Z with the carbon atom to which they are attached form a C═O; and in Formula I, L is selected from substituted C 1 -C 20 alkylene, C 3 -C 8 cycloalkylene substituted C 1 -C 20 alkylene wherein one or more of the —CH 2 — groups are independently replaced with C 3 -C 8 cycloalkylene, —S—, —NR 8 C(═O)—, —SO 2 NR 8 —, or —NR 8 SO 2 —; substituted C 1 -C 20 alkylene is C 1 -C 20 alkylene substituted with 1 to 4 —SO 3 H, —P(O)(OH) 2 or R 23 , wherein each R 23 is independently C 1-6 alkyl substituted with 1 or 2 substituents independently selected from the group consisting of —SH, —S—C 1-4 alkyl, —CONR 11 R 11 , —CO 2 H, and —NR 11 R 11 , wherein each R 11 is independently hydrogen, alkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, and heterocyclic, or the two R 11 together with the nitrogen form a heterocyclic, wherein the heterocyclic is optionally substituted with one or two oxo; in Formula I-1, L is selected from optionally substituted C 1 -C 20 alkylene, C 3 -C 8 cycloalkylene, optionally substituted C 1 -C 20 alkylene wherein one or more of the —CH 2 — groups are independently replaced with C 3 -C 8 cycloalkylene, —O—, —S—, —NR 8 —, —C(O)—, —C(═O)NR 8 —, —NR 8 C(═O)—, —SO 2 NR 8 —, or —NR 8 SO 2 —; substituted C 1 -C 20 alkylene is C 1 -C 20 alkylene substituted with 1 to 4 —SO 3 H, —P(O)(OH) 2 or R 23 , wherein each R 23 is independently C 1-6 alkyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of —SH, —S—C 1-4 alkyl, —CONR 11 R 11 , —CO 2 H, and —NR 11 R 11 , wherein each R 11 is independently hydrogen, alkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, and heterocyclic, or the two R 11 together with the nitrogen form a heterocyclic, wherein the heterocyclic is optionally substituted with one or two oxo.