Patent ID: 8563715

Claim:
A compound represented by Formula (1a), or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 , and R 3 are each selected independently from Formula (2a): wherein n is 1, 2, or 3; R 5 represents —H, carboxyl, (C1-C6) alkyl, (C1-C6) alkoxycarbonyl, (C1-C6) alkoxycarbonylmethyl, amino (C1-C6) alkyl (said amino group may be substituted with 1 or 2 (C1-C6) alkyl groups; or 1 (C1-C6) alkoxycarbonyl group; additionally, a carbonyl group may be contained in the carbon chain), piperazinyl (C1-C6) alkyl, (C1-C6) alkoxycarbonylpiperazinyl (C1-C6) alkyl, morpholino (C1-C6) alkyl, (C1-C6) alkylpiperizine, (C2-C6) alkenyl, (C2-C6) alkynyl, or phenyl group, wherein said phenyl group may further be substituted with 1 or 2 of R 6 ; R 6 represents —H, —F, —Cl, —Br, —I, (C1-C6) alkyl, (C1-C6) alkylamino, di (C1-C6) alkylamino, (C1-C6) alkoxy, (C1-C6) alkylthio, (C1-C6) acyl, pyrrolidinyl, piperidino, piperazinyl, (C1-C6) alkoxycarbonyl, (C1-C6) alkoxycarbonylamino, phenyl, benzyl, phenyl (C1-C6) alkyloxy, nitro, amino or hydroxyl group; Ar represents a phenyl, benzyl, pyridyl, pyrimidyl, thienyl, pyrrole, quinolinyl, thiazolyl, benzothiazolyl, thiadiazolyl, imidazolyl, tetrazolyl or pyridazinyl group which may be substituted with 1 or 2 of R 6 ; or a condensed ring group wherein 2 or more phenyl, benzyl, pyridyl, pyrimidyl, thienyl, pyrrole, quinolinyl, thiazolyl, benzothiazolyl, thiadiazolyl, imidazolyl, tetrazolyl or pyridazinyl groups, which may be substituted with 1 or 2 of R 6 , are condensed; G 1 is an oxygen atom, a sulfur atom, or a carbon atom or nitrogen atom substituted with R 7 ; further, in cases where it is a carbon atom substituted with R 7 , said carbon atom may form an unsaturated bond with an adjacent carbon atom; R 7 represents —H, (C1-C6) alkyl, amino (C1-C6) alkyl (which may contain a carbonyl group in the carbon chain), (C1-C6) alkylaminocarbonyl, (C1-C6) alkylaminothiocarbonyl, di (C1-C6) alkylaminosulfamoyl, (C1-C6) alkoxycarbonyl, (C1-C6) alkoxycarbonyl (C1-C6) alkyl, carboxy (C1-C6) alkyl, (C1-C6) alkoxycarbonylamino, (C1-C6) alkoxycarbonylamino (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C6) cycloalkyl, (C1-C6) acyl, nitro, cyano, hydroxyl or amino group; or a phenyl, benzyl, pyridyl, picolyl, pyrimidyl, quinolinyl, thiazolyl, benzothiazolyl, thiadiazolyl, imidazolyl, tetrazolyl or pyridazinyl group, which may be substituted with R 6 ; or, one of them is an amino group substituted with 1 or 2 of R 5 , or is a phenyl (C1-C6) alkyl group, and the remaining two are independently selected from said Formula (2a), and R 4 represents —F, —Cl, —Br, —I, formyl, phenyl, or (C1-C6) alkoxy group, wherein said phenyl group may be substituted with 1 or 2 of R 6 , provided that if any one of R 1 , R 2 , or R 3 is a phenyl (C1-C6) alkyl group, or Formula (4): then R 4 is —F, —Cl, —Br, —I, formyl, (C1-C6) alkyl, (C1-C6) alkoxy, amino, acetylamino, (C1-C6) alkylamino, di (C1-C6) alkylamino or cyano group, wherein said phenyl group may be substituted with 1 or 2 of R 6 .