Patent ID: 7273859

Claim:
A compound of Formula I wherein: R 1 is C 1-6 (Ar 1 )alkyl; R 2 is hydrogen, C 1-6 alkyl, or OR 6 ; R 3 is hydrogen, halo, hydroxy, cyano, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkoxy, CON(R 6 )(R 6 ), SOR 7 , SO 2 R 7 , SO 2 N(R 6 )(R 6 ), or Ar 2 ; R 4 is hydrogen, halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, or C 1-6 haloalkoxy; R 5 is hydrogen, halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, or C 1-6 haloalkoxy; R 6 is hydrogen or C 1-6 alkyl; R 7 is C 1-6 alkyl; R 8 and R 9 taken together are CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 2 CH 2 CH 2 CH 2 , CH 2 CH 2 CH 2 CH 2 CH 2 , CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 , OCH 2 CH 2 , CH 2 OCH 2 , OCH 2 CH 2 CH 2 , CH 2 OCH 2 CH 2 , OCH 2 CH 2 CH 2 CH 2 , CH 2 OCH 2 CH 2 CH 2 , CH 2 CH 2 OCH 2 CH 2 , OCH 2 CH 2 CH 2 CH 2 CH 2 , CH 2 OCH 2 CH 2 CH 2 CH 2 , CH 2 CH 2 OCH 2 CH 2 CH 2 , N(R 6 )CH 2 CH 2 , CH 2 N(R 6 )CH 2 , N(R 6 )CH 2 CH 2 CH 2 , CH 2 N(R 6 )CH 2 CH 2 , N(R 6 )CH 2 CH 2 CH 2 CH 2 , CH 2 N(R 6 )CH 2 CH 2 CH 2 , CH 2 CH 2 N(R 6 )CH 2 CH 2 , N(R 6 )CH 2 CH 2 CH 2 CH 2 CH 2 , CH 2 N(R 6 )CH 2 CH 2 CH 2 CH 2 , or CH 2 CH 2 N(R 6 )CH 2 CH 2 CH 2 ; Ar 1 is Ar 2 is tetrazolyl, triazolyl, imidazolyl, pyrazolyl, pyrrolyl, or dioxothiazinyl, and is substituted with 0-2 substituents selected from the group consisting of amino, oxo, halo, cyano, and C 1-6 alkyl; and X—Y-Z is C(R 8 )(R 9 )CH 2 CH 2 , C(R 8 )(R 9 )CH 2 CH 2 CH 2 , C(R 8 )(R 9 )CH 2 CH 2 CH 2 CH 2 , C(R 8 )(R 9 )OCH 2 , C(R 8 )(R 9 )OCH 2 CH 2 , or C(R 8 )(R 9 )OCH 2 CH 2 CH 2 ; or a pharmaceutically acceptable salt or solvate thereof.