Patent ID: 8247414

Claim:
A compound according to formula I*: or a stereoisomeric form, mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof; wherein: X and X a are each CH; Y is S(O) q or O; R 1 is selected from piperidinyl or pyrrolidinyl optionally substituted with 1 to 3 R 20 groups; R 2 is wherein: R 2 is para to the Y—(CHR 4 ) m —R 1 group; and each R 3 is: independently H, F, Cl, Br, I, OR 21 , NR 23 R 24 , NO 2 , CN, CF 3 , C 1 -C 6 alkyl, C(═O )R 21 , CO 2 R 21 , or C(═O)NR 23 R 24 ; or when R 3 is ortho to R 2 , then R 3 and R 14 taken together may form —(CH 2 ) s —, —CH 2 Z—, —ZCH 2 —, —ZCH 2 CH 2 — or CH 2 CH 2 Z—; wherein Z is O or S(O) y ; each R 4 is independently H or C 1 -C 6 alkyl, wherein the alkyl group is optionally substituted with 1 to 3 R 20 groups; R 12 is H, C 1 -C 6 alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, C(═O)R 27 , or CO 2 R 27 , wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heterocycloalkyl group is optionally substituted with 1 to 3 R 20 groups; R 13 and R 14 are each independently H, C 1 -C 6 alkyl, aryl, arylalkyl C 1 -C 6 alkoxyl, S(═O) y —C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, or heteroaryl; or R 13 and R 14 , taken together with the carbon atoms through which they are connected form a fused thienyl, pyrrolyl, isoxazolyl, or C 3 -C 6 cycloalkyl ring; and wherein the fused thienyl, pyrrolyl, isoxazolyl, or cycloalkyl ring is optionally substituted with 1 to 3 R 20 groups; R 20 at each occurrence is independently, H, F, Cl, Br, I, NR 23 R 24 , C 1 -C 6 alkyl optionally substituted with OR 26 , C 3 -C 7 cycloalkylC 0 -C 4 alkyl, or 3- to 7-membered heterocycloalkylC 0 -C 4 alkyl; each R 23 and R 24 is independently selected from H, C 1 -C 6 alkyl, and aryl, or R 23 and R 24 , together with the nitrogen atom to which they are attached, form a 3 to 7 membered heterocyclic ring optionally substituted with ═O; R 26 is H, C 1 -C 6 alkyl, aryl, or alkylaryl; R 27 is H or C 1 -C 6 alkyl; m is 1, 2, 3, 4, or 5 when R 1 is attached via a nitrogen atom, and m is 0, 1, 2, 3, 4, or 5 when R 1 is attached via a carbon atom; n is 1 or 2; q is 0, 1, or 2; s is 1, 2, or 3; and y is 0, 1, or 2; provided that: (1) when Y is O, n is 2, R 3 is H, each R 4 is H, m is 2, 3, or 4, and R 1 is pyrolidin-1-yl or piperidin-1-yl, then R 2 is other than 4,5-dihydro-2H-pyridazin-3-one-6-yl.