Patent ID: 8772504

Claim:
A compound of formula (I) or a stereoisomeric form thereof, wherein R 1 is hydrogen, cyano, CF 3 , halo, or C 1-4 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of hydroxyl and C 1-4 alkyloxy; R 2 is hydrogen, C 1-4 alkyl or halo; X is CR 5 or N; R 5 is hydrogen or halo; A 1 is CR 6 or N; R 6 is hydrogen, halo or C 1-4 alkyloxy; A 2 , A 3 and A 4 each independently are CH, CF or N; provided that no more than two of A 1 , A 2 , A 3 and A 4 are N; Y 1 is CH Y 2 is CR 4 ; Y 3 is CH; R 4 is hydrogen, halo, C 1-4 alkyloxy, cyano, cycloC 3-7 alkyl, C 2-4 alkenyl, or C 1-4 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo and C 1-4 alkyloxy; R 3 is C 2-6 alkyl substituted with one or more halo substituents; C 1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of piperidinyl, morpholinyl, pyrrolidinyl, Ar, C 1-6 alkyloxy, tetrahydropyranyl, cycloC 3-7 alkyloxy and cycloC 3-7 alkyl; cycloC 3-7 alkyl substituted with one or more phenyl substituents optionally substituted with one or more halo substituents; cycloC 3-7 alkyl; piperidinyl; morpholinyl; pyrrolidinyl; tetrahydropyranyl; O—Ar; NR 7 R 8 ; C 1-6 alkyloxy; C 1-6 alkylthio; Ar; CH 2 —O—Ar; S—Ar; NCH 3 —Ar; NH—Ar; or 1,6-dihydro-1-methyl-6-oxo-3-pyridinyl; wherein each piperidinyl, morpholinyl and pyrrolidinyl may be substituted with one or more substituents each independently selected from the group consisting of C 1-4 alkyl, C 2-6 alkenyl, C 1-4 alkylcarbonyl, halo and C 1-4 alkyloxycarbonyl; wherein each Ar independently is phenyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy, cyano, NR 7 R 8 , morpholinyl, C 1-4 alkyl, C 1-4 alkyloxy substituted with one or more halo substituents, and C 1-4 alkyl substituted with one or more halo substituents; or a 5- or 6-membered heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, oxazolyl, furanyl, thiophenyl, pyrazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, pyridazinyl and pyrazinyl; wherein said 5- or 6-membered heteroaryl is optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy, cyano, C 1-4 alkyl, C 1-4 alkyloxy substituted with one or more halo substituents, and C 1-4 alkyl substituted with one or more halo substituents; each R 7 is selected independently from hydrogen or C 1-4 alkyl; each R 8 is selected independently from hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl; Z is NR 9 ; R 9 is hydrogen, or C 1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, cyano, phenyl, cycloC 3-7 alkyl and C 1-4 alkyloxy; or a pharmaceutically acceptable addition salt thereof.