Patent ID: 8133707

Claim:
A method of preparing a polymer having a lone electron pair-containing moiety thereon, comprising: reacting a polymer of formula (I) R 2 -R 1 -(L 1 ) n -LG (I) wherein R 1 is a substantially non-antigenic polymer; R 2 is a capping group, LG or LG-(L 1 ) n -; L 1 is a bifunctional linker; LG is a leaving group selected from the group consisting of wherein R 3 is methyl, halogen, nitro, fluoromethyl, difluoromethyl, trifluoromethyl, or substituted carboxyl; a multi-halogen substituted benzenesulfonyl; mesylate; brosylate; tresylate, and nosylate; and n is 0 or positive integer, with a compound of Formula (III) in an aqueous base at a temperature of from about 45 to about 50° C. and for a reaction time of less than about 18 hours, wherein the compound of Formula (III) is wherein Z is NR 7 ; X is O, S or NR 8 ; m is a positive integer; R 4 is H; R 5 , R 6 , R 7 and R 8 are independently selected from the group consisting of H, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy, provided that R 4 and R 7 are both not H; and the aqueous base is selected from the group consisting of NaOH, KOH, LiOH, Mg(OH) 2 , Ca(OH) 2 and mixtures thereof, wherein 10 molar equivalent of compound of Formula (III) is employed for each equivalent of LG; and the purity of the polymer having the lone electron pair-containing moiety thereon formed by said method is greater than 95%.