Patent ID: 8268868

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof wherein R 5 is H or lower alkyl which is optionally substituted by up to 3 halo atoms; m and p are each 0 or 1, provided that m+p is at least 1; R 3 and R 4 are each independently selected from H, —OH and lower alkyl; R is —OH, alkoxy, hydroxyalkoxy, alkoxyalkoxy, or —NR 1 R 2 , wherein (i) R 1 and R 2 are each independently selected from H and optionally substituted alkyl, or (ii) R 1 and R 2 , together with the N atom to which they are attached, form a 4 to 7-membered optionally substituted non-aromatic ring system which optionally contains 1 or 2 heteroatoms in addition to the N atom shown, or (iii) NR 1 R 2 , taken together with CR 3 R 4 and, if present, the CH 2 between NR 1 R 2 and CR 3 R 4 , forms a 5 to 10-membered optionally substituted non-aromatic ring system which optionally contains 1 or 2 heteroatoms in addition to the N atom shown; X is selected from —O—, —NH—, —N-alkyl-, and —CH 2 —; R 6 is selected from H and lower alkyl; or X and CHR 6 are taken together to form —CH═CH—; Y is selected from C 3-10 non-aromatic hydrocarbon and wherein B is an aromatic hydrocarbon or aromatic heterocycle, and R 7 , R 8 and R 9 are each independently selected from H, —OH, —O-alkyl, -alkyl, halo, —S(O)-alkyl, —SO 2 -alkyl, —CF 3 , —CN and phenyl, wherein the compound is not in the form of a solvate or a pharmaceutically acceptable salt thereof.