Patent ID: 7189716

Claim:
A compound according to formula I: its enantiomers, diastereomers, pharmaceutically acceptable salts, hydrates, prodrugs and solvates thereof; wherein A, B, and are each C; D is N; X is selected from the group consisting of N or C wherein each of said N or C may be optionally substituted, independently, with R 7 and n is 0, 1, 2, or 3; Y is selected from the group consisting of O and S; W is selected from the group consisting of N, C, O, and S, provided that when W is O or S, R 41 is absent; R 3 is morpholine R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 41 , and R 42 are each independently selected from the group consisting of H, C 1-6 alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, halo, amino, aminoalkyl, alkoxy, thioalkoxy, nitro, aryl, heteroaryl, alkoxyalkyl, thioalkoxyalkyl, aminoalkyl, aralkyl, heteroarylalkyl, heterocycloalkylalkyl, —CN, —CO 2 R 8 , —CONR 9 R 10 , —CO 2 NR 11 R 12 , —NR 13 CONR 14 R 15 , —NR 16 SO 2 R 17 , —SO 2 NR 18 R 19 , —C(NR 20 )NR 21 R 22 , —NH-Z, —NH-Z-aryl, and NH-Z-heteroaryl, or any two of R 2 and R 3 , R 3 and R 4 , or R 4 and R 5 can be taken together to form a heterocyclic ring having at least one nitrogen atom; Z is selected from the group consisting of C 1 –C 6 alkyl, cycloalkyl, alkenyl, cycloalkenyl, and alkynyl; Z optionally having one or more hydroxy, thiol, alkoxy, thioalkoxy, amino, halo, NR 23 S 2 R 24 groups and optionally incorporating one or more groups selected from —CO, —CNOH, —CNOR 26 , —CNNR 27 , —CNNCOR 28 or —CNNSO 2 R 29 ; R 8 ,R 9 ,R 10 ,R 11 ,R 12 ,R 13 ,R 14 ,R 15 ,R 16 ,R 17 ,R 18 ,R 19 ,R 20 ,R 21 ,R 22 ,R 23 ,R 24 , and R 26 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, hydroxy, alkoxy, aryl, heteroaryl, heterocyclyl, heteroarylalkyl, and alkyl-R 25 wherein R 25 is alkenyl, hydroxy, thiol, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, aryl, heteroaryl, cyano, halo, heteroaryl, heterocyloalkyl, sulfoxy, sulfonyl, —NR 27 COOR 28 , —NR 29 C(O)R 30 , —NR 31 SOI 2 R 32 , SO 2 NR 31 R 32 , —C(O)NR 33 R 34 , and; R 27 ,R 28 ,R 29 ,R 30 ,R 31 ,R 32 ,R 33 and R 34 are, independently, hydrogen, alkyl, or cycloalkyl.