Patent ID: 6956053

Claim:
A compound of the formula (I), (IIa) or (IIb) wherein n is from 1 to 4; R 1 is C 1 to C 15 hydrocarbyl wherein up to three C atoms may optionally be replaced by an atom independently selected from the group consisting of N, O, and S, and up to three H atoms may optionally be replaced by halogen atoms; R 2 is selected from the group consisting of H, Me, Et, Pr and OH, each R 2 being independently selected from the group consisting of H, Me, Et, Pr and OH when n is greater than 1; R 3 is selected from the group consisting of H, Me, Et and Pr when n is 1; or, when n is greater than 1, each R 3 is independently selected from the group consisting of H, Me, Et and Pr, or two R 3 groups on neighbouring carbon atoms are linked to form a C 3 to C 6 carbocylic ring, or two R 3 groups are absent from neighbouring carbon atoms which are linked by a double bond; or R 2 and R 3 on the same carbon atom together represent an ═O group; R 4 is C 1 to C 15 hydrocarbyl wherein up to two C atoms may optionally be replaced by an atom independently selected from the group of N, O, and S and up to three H atoms may optionally be replaced by halogen atoms; R 5 is H, OH or C 1 to C 15 hydrocarbyl wherein up to two C atoms may optionally be replaced by an atom independently selected from the group consisting of N, O, and S and up to three H atoms may optionally be replaced by halogen atoms; R 6 is H or C 1 to C 15 hydrocarbyl wherein up to two C atoms may optionally be replaced by an atom independently selected from the group consisting of N, O, and S and up to three H atoms may optionally be replaced by halogen atoms; Z is selected from the group consisting of: —(NR 7 ) a —CO—(NR 8 ) b —, (wherein a is 0 or 1, b is 0 or 1, and R 7 and R 8 are independently selected from the group consisting of H, Me, Et, Pr or Bn; —CO—NR 7 —CH 2 —CO—NR 8 —; —CO—O—; —CH 2 —CH 2 —; —CH═CH—; —CH 2 —NR 8 —; and a bond; Q is —R 9 V, or wherein R 9 is —CH 2 —; —CH 2 —CH 2 —; or or R 9 and R 8 , together with the nitrogen atom to which R 8 is attached, form a piperidine or pyrrolidine ring which is substituted by V; V is selected from the group consisting of —CO—NH—SO 2 -Ph, —SO 2 —NH—CO-Ph, and a group of the formula —R 10 U, wherein U is selected from the group consisting of —COOH, tetrazolyl, —CONHOH— or —SO 3 H; and R 10 is selected from the group consisting of a bond; C 1 to C 6 hydrocarbylene, optionally substituted by hydroxy, amino or acetamido; —O—(C 1 to C 3 alkylene)-; —SO 2 NR 11 —CHR 12 —; —CO—NR 11 —CHR 12 —, wherein R 11 and R 12 are independently selected from H and methyl; or —NH—(CO) c —CH 2 —, c being 0 or 1; T is selected from the group consisting of C 1 to C 6 hydrocarbyl, —NR 7 R 8 (wherein R 7 and R 8 wherein R 7 and R 8 are as defined above, —OMe, —OH, —CH 2 OH, halogen and trihalomethyl; m is 1 or 2; p is from 0 to 3; and q is from 0 to 2, with the proviso that q is 1 or 2 when Z is a bond; or a pharmaceutically acceptable salt thereof.