Patent ID: 8304425

Claim:
A compound of formula I, II, III, or IV, or pharmaceutically acceptable salts thereof: wherein: R1, R2, and R3 are independently selected from the group consisting of H, F, Cl, Br, I, —NR7R8, —(C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —(C3-C9) substituted cycloalkyl, —O—(C1-C6) alkyl, —O—(C3-C9) cycloalkyl, and —O—(C3-C9) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl; R4 is selected from the group consisting of H, —(C1-C4) alkyl, and —(C1-C4) substituted alkyl; R5 is selected from the group consisting of H, —(C1-C6) alkyl, —CH 2 R6, —CONHR9, —COR10, and —SO 2 R11; R6 is selected from the group consisting of —O—P(═O)(OH) 2 , —O—P(═O)(—OH)(—O—(C1-C6) alkyl), —O—P(═O)(—O—(C1-C6) alkyl) 2 , —O—P(═O)(—OH) (—O—(CH 2 )-phenyl), —O—P(═O)(—O—(CH 2 )-phenyl) 2 , a carboxylic acid group, an amino carboxylic acid group, and a peptide; R7 and R8 are independently selected from the group consisting of H and —(C1-C6) alkyl; R9, R10, and R11 are independently selected from the group consisting of H, NHR12, —(C1-C6)alkyl, —(C1-C6) substituted alkyl, —(C3-C9)cycloalkyl, —(C3-C9) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl; Q is selected from the group consisting of indolyl, substituted indolyl, aryl, heteroaryl, heterocyclyl, and alkyl; V and Z are independently selected from the group consisting of O, S, H 2 ; provided that at least one of V and Z is H 2 ; X is selected from the group consisting of —CH 2 —, —NR12, S, O, and a bond; R12 is selected from the group consisting of H, —(C1-C6) alkyl, —(C1-C6) substituted alkyl, —(C3-C9) cycloalkyl, —(C3-C9) substituted cycloalkyl, —O—(C1-C6) alkyl, —C(═O)—O—(C1-C6) alkyl, and —C(═O)—O—(C1-C6) substituted alkyl; W is selected from the group consisting of —CH 2 —, CO, and a bond; and m is 0, 1 or 2.