Patent ID: 7393872

Claim:
A method of treating or ameliorating neuropathic pain, comprising administering to a patient in need thereof a first agent which is a semicarbazone represented by Formula I where R 1 -R 4 are independently hydrogen, halogen, C 1-9 alkyl, C 3-9 cycloalkyl, cyano, C 1-9 alkoxy, or C 6-10 aryloxy; R 5 is hydrogen, C 1-9 alkyl, C 3-9 cycloalkyl, or C 6-10 aryl; and X is oxygen or sulfur; and a second agent selected from the group consisting of gabapentin, pregabalin, salts thereof and combinations thereof; wherein said first agent and said second agent are present in synergistic amounts effective to treat or ameliorate neuropathic pain.