Patent ID: 8658666

Claim:
A compound of the Formula II: wherein: R 3 is selected from the group consisting of: -Z-Y-R 4 , and -Z-R 5 ; R is selected from the group consisting of alkyl, alkoxy, hydroxy, halogen, and trifluoromethyl; n is 0 or 1; R 1 is selected from the group consisting of alkyl, alkoxyalkylenyl, dihydroxyalkylenyl, hydroxyalkylenyl, and alkyl substituted by a group selected from the group consisting of —NH—C(O)-alkyl, —NH—S(O) 2 -alkyl, —NH—C(O)—NH-alkyl, tetrahydropyranyl, phenoxy, 1,1-dioxidoisothiazolidin-2-yl, and 2-oxo-pyrroldin-1-yl;: R 2 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and hydroxyalkylenyl; Z is selected from the group consisting of a bond, and alkylene; Y is selected from the group consisting of: —S(O) 0-2 —, —S(O) 2 —N(R 8 )—, —C(R 6 )—, —N(R 8 )-Q-, —C(R 6 )—N(R 8 )—, and —O—C(R 6 )—N(R 8 )—, R 4 is selected from the group consisting of hydrogen, alkyl, and heterocyclyl wherein the alkyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, hydroxy, amino, alkylamino, dialkylamino, and in the case of alkyl, and heterocyclyl, oxo; R 5 is selected from the group consisting of: R 6 is ═O; R 7 is C 2-7 alkylene; R 8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and hydroxyalkylenyl; A is selected from the group consisting of —O—, —CH 2 —, —C(O)—, —S(O) 0-2 —, and —N(R 4 )—; Q is selected from the group consisting of a bond, —C(R 6 )—, —S(O) 2 —, —C(R 6 )—N(R 8 )—W—, —S(O) 2 —N(R 8 )—, —C(R 6 )—O—, and V is selected from the group consisting of —C(R 6 )—, —O—C(R 6 )—, —N(R 8 )—C(R 6 )—, and —S(O) 2 —; W is a bond; and a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7; with the proviso that when R 3 is -Z-Y-R 4 and Z is a bond, then Y is selected from the group consisting of —N(R 8 )-Q-, S(O) 0-2 , and —C(R 6 )— wherein Q is selected from the group consisting of —C(R 6 )—, S(O) 2 —, —C(R 6 )—N(R 8 )—W—; and with the further proviso that when R 3 is -Z-R 5 , then Z is alkylene or alkenylene; or a pharmaceutically acceptable salt thereof.