Patent ID: 7314887

Claim:
A compound of Formula III: or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: R 1 is selected from CO 2 R 10 , CONR 10 R 11 , SO 3 R 10 , and a carboxylic acid bioisostere; R 2 and R 3 are each independently selected from null, hydrogen, OR 12 , NR 12 R 13 , an optionally substituted C 1 -C 4 aliphatic, an optionally substituted C 1 -C 4 haloaliphatic, an optionally substituted C 1 -C 4 heteroaliphatic, an optionally substituted ring, and (CH 2 ) m R 14 ; or R 2 and R 3 taken together form an optionally substituted olefin; or R 2 and R 3 are linked to form an optionally substituted C 3 -C 8 ring; R 4 is selected from hydrogen, F, Cl, Br, C 1 -C 4 aliphatic, C 1 -C 4 haloaliphatic, C 1 -C 4 heteroaliphatic, and a ring; R 5 is selected from hydrogen, OR 10 , SR 10 , NHR 11 , and CO 2 H; R 6 is selected from hydrogen, OR 12 , NR 12 R 13 , F, Cl, Br, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, and C 1 -C 4 heteroalkyl; R 7 is selected from hydrogen, an optionally substituted C 1 -C 8 aliphatic, an optionally substituted C 1 -C 8 haloaliphatic, an optionally substituted C 1 -C 8 heteroaliphatic, an optionally substituted C 1 -C 8 heterohaloaliphatic, an optionally substituted ring, and (CH 2 ) m R 14 ; R 8 and R 9 are each independently selected from hydrogen, F, Cl, Br, CO 2 R 10 , NO 2 , CN, SO 2 R 10 , (CH 2 ) m R 14 , C 1 -C 4 aliphatic, C 1 -C 4 haloaliphatic, C 1 -C 4 heteroaliphatic, and C 1 -C 4 heterohaloaliphatic; R 10 is selected from hydrogen, an optionally substituted C 1 -C 4 aliphatic, C 1 -C 4 haloaliphatic, C 1 -C 4 heteroaliphatic, and a ring; R 11 is selected from hydrogen, SO 2 R 15 , C 1 -C 4 aliphatic, C 1 -C 4 haloaliphatic, C 1 -C 4 heteroaliphatic, and a ring; R 12 and R 13 are each independently selected from hydrogen, an optionally substituted C 1 -C 4 aliphatic, an optionally substituted C 1 -C 4 haloaliphatic, an optionally substituted C 1 -C 4 heteroaliphatic, an optionally substituted ring, and (CH 2 ) m R 14 ; or one of R 12 and R 13 is an optionally substituted C 2 -C 6 aliphatic or an optionally substituted ring and the other of R 12 and R 13 is null; or R 12 and R 13 are linked to form an optionally substituted C 3 -C 8 ring; R 14 is selected from an optionally substituted aryl and an optionally substituted heteroaryl; R 15 is selected from hydrogen, C 1 -C 3 aliphatic, C 1 -C 3 haloaliphatic, and a ring; m is 0, 1, or 2; and n is 0 or 1.