Patent ID: 7491704

Claim:
A method of treating cancer, comprising administering a compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof, wherein each A is independently selected from C═O, C═S, and SO 2 ; or A is optionally a covalent bond when adjacent to an occurrence of Z; L is absent or is selected from C═O, C═S, and SO 2 ; M is absent or is C 1-12 alkyl; Q is absent or is selected from O, NH, and N—C 1-6 alkyl; X is selected from O, NH, and N—C 1-6 alkyl; Y is absent or is selected from O, NH, N—C 1-6 alkyl, S, SO, SO 2 , CHOR 10 , and CHCO 2 R 10 ; each Z is independently selected from O, S, NH, and N—C 1-6 alkyl; or Z is optionally a covalent bond when adjacent to an occurrence of A; R 1 and R 3 are independently optionally substituted C 1-6 aralkyl; R 2 and R 4 are independently selected from optionally substituted C 1-6 alkyl, C 1-6 hydroxyalkyl, and C 1-6 alkoxyalkyl; R 5 is N(R 6 )LQR 7 ; R 6 is selected from hydrogen, OH, and C 1-6 alkyl; R 7 is selected from hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, aryl, C 1-6 aralkyl, heteroaryl, C 1-6 heteroaralkyl, R 8 ZAZ-C 1-8 alkyl-, R 11 Z-C 1-8 alkyl-, (R 8 O)(R 9 O)P(═O)O—C 1-8 alkyl-ZAZ-C 1-8 alkyl-, R 8 ZAZ-C 1-8 alkyl-ZAZ-C 1-8 alkyl-, heterocyclylMZAZ-C 1-8 alkyl-, (R 8 O)(R 9 O)P(═O)O—C 1-8 alkyl-, (R 10 ) 2 N—C 1-12 alkyl-, (R 10 ) 3 N + —C 1-12 alkyl-, heterocyclylM-, carbocyclylM-, R 11 SO 2 C 1-8 alkyl-, and R 11 SO 2 NH; or R 6 and R 7 together are C 1-6 alkyl-Y—C 1-6 alkyl, C 1-6 alkyl-ZAZ-C 1-6 alkyl, ZAZ-C 1-6 alkyl-ZAZ-C 1-6 alkyl, ZAZ-C 1-6 alkyl-ZAZ, or C 1-6 alkyl-A, thereby forming a ring; R 8 and R 9 are independently selected from hydrogen, metal cation, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, aryl, heteroaryl, C 1-6 aralkyl, and C 1-6 heteroaralkyl, or R 8 and R 9 together are C 1-6 alkyl, thereby forming a ring; each R 10 is independently selected from hydrogen and C 1-6 alkyl; and R 11 is independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, C 1-6 aralkyl, and C 1-6 heteroaralkyl, provided that when R 6 is H or CH 3 and Q is absent, LR 7 is not hydrogen, unsubstituted C 1-6 alkylC═O, a further chain of amino acids, t-butoxycarbonyl (Boc), benzoyl (Bz), fluoren-9-ylmethoxycarbonyl (Fmoc), triphenylmethyl(trityl), benzyloxycarbonyl (Cbz), trichloroethoxycarbonyl (Troc); or substituted or unsubstituted aryl or heteroaryl; and in any occurrence of the sequence ZAZ, at least one member of the sequence must be other than a covalent bond.