Patent ID: 7033589

Claim:
A method of inhibiting production of IgE in a human subject with an IgE-mediated allergic disorder comprising parenterally administering an IgE production inhibiting amount of an anti-human CD23 monoclonal antibody comprising a human gamma-1 constant region; which antibody comprises the complementarity-determining regions CDR1, CDR2, and CDR3 of the light and heavy chains of antibody 6G5 or of antibody 5E8; wherein CDR1, CDR2, and CDR3 of the light chain of antibody 6G5 are the polypeptides encoded by nucleotides 124-165, 211-231, and 328-357, respectively, of SEQ ID NO. 1; CDR1, CDR2, and CDR3 of the heavy chain of antibody 6G5 are the polypeptides encoded by nucleotides 148-165, 208-258, and 355-390, respectively, of SEQ ID NO. 3; CDR1, CDR2, and CDR3 of the light chain of antibody 5E8 are the polypeptides encoded by nucleotides 136-168, 214-234, and 331-357 respectively, of SEQ ID NO. 5; and CDR1, CDR2, and CDR3 of the heavy chain of antibody 5E8 are the polypeptides encoded by nucleotides 148-168, 211-261, and 358-378, respectively, of SEQ ID NO. 7.