Patent ID: 7022730

Claim:
A compound of Formula (I): wherein R 1 and R 2 are independently selected from the group consisting of R 3 is (a) hydrogen; (b) alkyl; (c) alkenyl; or (d) alkynyl; R 4 in combination with R 5 is: 5-carboxy -2-furyl; 5-hydroxymethylfuran-2-yl; or 5-methoxycarbonylmethoxymethyl-2-furyl; R 6 , R 6 ′, R 7 , R 7 ′, R 8 , and R 8 ′ are independently selected from the group consisting of (a) hydrogen; (b) aryl; (c) heteroaryl; (d) heterocyclyl; (e) cycloalkyl; (f) halogen; and (g) -alkylene-Y-aryl; -alkenylene-Y-aryl; -alkynylene-Y-aryl; -alkylene-Y-heteroaryl; -alkenylene-Y-heteroaryl; -alkynlene-Y-heteroaryl; -alkylene-Y-cycloalkyl -alkenylene-Y-cycloalkyl; -alkynlene-Y-cycloalkyl; -alkylene-Y-heterocyclyl; -alkenylene-Y-heterocyclyl; -alkynlene-Y-heterocyclyl; —Y-alkyl; —Y-aryl; —Y-alkylene-aryl; —Y-alkylene-NR 11 R 12 ; —Y—O—Si-(alkyl) 3 ; and —Y—O—Si-(alkylene-aryl) 3 ; wherein Y is —CH 2 —, —C(O)—, —O—, —N(H)—, —S—, —S(O)—, —S(O 2 )—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHS(O 2 )—, —S(O 2 )N(H)—, —C(O)—O—, —NHS(O 2 )NH—, or —O—CO—; and R 11 and R 12 are independently selected from the group consisting of: hydrogen, aryl, alkyl, and alkylene-aryl; or R 11 and R 12 are taken together to form a ring having the formula —(CH 2 ) q -Q-(CH 2 ) r — bonded to the nitrogen atom to which R 11 and R 12 are attached, wherein q and r are, independently, 1, 2, 3, or 4; Q is —CH 2 —, —C(O)—, —O—, —N(H)—, —S—, —S(O)—, —SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —(O)CO—, —NHSO 2 NH—, —OC(O)—, —N(R 13 )—, —N(C(O)R 13 )—, —N(C(O)NHR 13 )—, —N(SO 2 NHR 13 )—, —N(SO 2 R 13 )—, or —N(C(O)OR 13 )—; or R 11 and R 12 are taken together, with the nitrogen atom to which they are attached, to form a heterocyclyl or heteroaryl ring; R 9 , R 10 , and R 13 are independently selected from the group consisting of hydrogen, aryl, alkyl, and alkylene-aryl; A 1 and A 2 are N—R 14 , where R 14 is (a) alkyl; or (b) -alkylene-aryl R 17 and R 18 are independently selected from the group consisting of hydrogen, alkyl, and halogen; Ar 1 and Ar 2 are phenyl; or a pharmaceutically acceptable salt, solvate or prodrug thereof.