Patent ID: 7417170

Claim:
A method for the preparation of a substituted 3-aryl-butyl-amine compound corresponding to formula I wherein R 1 is chosen from H, C 1-3 -alkyl, which is branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R 2 and R 3 in each case independently of one another are chosen from H or C 1-4 -alkyl, which is branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or R 2 and R 3 together form a saturated C 4-7 -cycloalkyl radical, which is unsubstituted or mono- or polysubstituted, R 4 is chosen from H, C 1-3 -alkyl, which is branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R 7 and R 8 in each case independently of one another are chosen from H or C 1-3 -alkyl, which is branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R 9 to R 13 in each case independently of one another are chosen from H, F, Cl, Br, I, CH 2 F, CHF 2 , CF 3 , OH, SH, OR 14 , OCF 3 , SR 14 , NR 17 R 18 , SOCH 3 , SOCF 3 ; SO 2 CH 3 , SO 2 CF 3 , CN, COOR 14 , NO 2 , CONR 17 R 18 ; C 1-6 -alkyl, which is branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, which is unsubstituted or mono- or polysubstituted; where R 14 is chosen from C 1-6 -alkyl; pyridyl, thienyl, thiazolyl, phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted; PO(O—C 1-4 -alkyl) 2 , CO(OC 1-5 -alkyl), CONH—C 6 H 4 -(C 1-3 -alkyl), CO(C 1-5 -alkyl), CO—CHR 17 —NHR 18 , CO—C 6 H 4 —R 15 , where R 15 is ortho-OCOC 1-3 -alkyl or meta- or para-CH 2 N(R 16 ) 2 , where R 16 is C 1-4 -alkyl or 4-morpholino, wherein in the radicals R 14 , R 15 and R 16 the alkyl groups can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; where R 17 and R 18 in each case independently of one another are chosen from H; C 1-6 -alkyl, which is branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted, or R 9 and R 10 or R 10 and R 11 together form an OCH 2 O, OCH 2 CH 2 O, OCH═CH, CH═CHO, CH═C(CH 3 )O, OC(CH 3 )═CH, (CH 2 ) 4 or OCH═CHO ring, in each case in the form of one of its stereoisomers, its racemates or in the form of a mixture of stereoisomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, said method comprising the step of: hydrogenating a substituted 3-aryl-but-3-enyl-amine compound corresponding to formula III in the presence of a platinum or palladium catalyst and hydrogen to produce a substituted 3-aryl-butyl-amine compound corresponding to formula I