Patent ID: 7595328

Claim:
A method for modulating inhibiting the growth of a Haemophilus influenzae strain comprising contacting the H. influenzae strain with a composition comprising an antibacterially effective amount of gemifloxacin, gemifloxacin mesylate, or gemifloxacin mesylate sesquihydrate, wherein the H. influenzae strain comprises a mutation in parE that results in at least one of the following changes in the amino acid sequence of the ParE protein: replacement of Gly at position 405 with Ser, replacement of Asp at position 420 with Asn, replacement of Ser at position 458 with Leu, replacement of Ser at position 458 with Ala, insertion of a Ser between the Ser at position 458 and the Thr at position 459, and replacement of the Ser at position 474 with Asn.