Patent ID: 7119115

Claim:
A compound of formula (1) or formula (2) wherein: X and Y are N; Ar is: phenyl optionally substituted with one or more substituents selected from the group consisting of: halogen, (C 1 –C 4 )alkyl, (C 1 –C 4 )alkoxy, thio(C 1 –C 4 )alkyl, NO 2 , NH(C 1 –C 4 )alkyl and N((C 1 –C 4 )alkyl) 2 wherein said alkyl may optionally form a 4 to 6 membered ring together with the heteroatom to which it is attached and an ortho carbon of the phenyl wherein said 4 to 6 membered ring may contain a second hetero atom selected from the group consisting of O, S and N, Z is H, 4-aminophenyl, SO 2 R 3 or COR 3 wherein R 3 is (C 1 –C 4 )alkyl, (C 3 –C 6 )cycloalkyl, Ar as defined above, (C 2 –C 6 )alkenyl or (C 2 –C 6 )alkynyl; R 1 is H, (C 1 –C 4 )alkyl, (C 3 –C 6 )cycloalkyl or Ar as defined above; R′ is H or (C 1 –C 4 )alkyl; and when Z is H, R 2 is selected from the group consisting of: cyano, C(O)—ORa 1 wherein Ra 1 is methyl, ethyl or isopropyl, C(O)—NHRa 2 wherein Ra 2 is cyclopropyl, C(O)—N(Ra 2 ′), wherein N(Ra 2 ′) is aziridinyl or azetidinyl, optionally substituted with (C 1 –C 4 )alkyl or Ar as defined above, C(O)—N(Ra 3 )—ORa 3 wherein each Ra 3 may be identical or different and each Ra 3 is independently selected from the group consisting of methyl, ethyl or cyclopropyl, C(O)Ra 4 wherein Ra 4 is Ar as defined above or (C 3 –C 5 )cycloalkyl optionally substituted with (C 1 –C 4 )alkyl or Ar as defined above, C(Ra 4 )═N—Rb wherein: Ra 4 is H, Ar as defined above, or (C 3 –C 5 )cycloalkyl optionally substituted with (C 1 –C 4 )alkyl or Ar as defined above, and Rb is (C 1 –C 2 )alkyl, (C 3 –C 5 )cycloalkyl, hydroxyl, (C 1 –C 4 )alkoxy, (C 2 –C 4 )alkenyloxy, or (C 1 –C 4 )alkylenoxy wherein said (C 1 –C 4 )alkylenoxy optionally may be substituted with halogen or a group selected from the group consisting of carboxyl, (CH 2 ) n Ar wherein n is 0 or 1 and Ar is as defined above, (C 1 –C 4 )alkoxy, NH 2 , NH(C 1 –C 4 )alkyl, and N((C 1 –C 4 alkyl) 2 wherein said alkyls together with the heteroatom to which they are attached may optionally form a 3 to 6 membered ring which may optionally contain a second hetero atom selected from the group consisting of O, S and N, NH—C(O)Ra 4 wherein Ra 4 is H, Ar as defined above, or (C 3 –C 5 )cycloalkyl optionally substituted with (C 1 –C 4 )alkyl or Ar as defined above, NHRa 4 wherein Ra 4 is H, Ar as defined above, or (C 3 –C 5 )cycloalkyl optionally substituted with (C 1 –C 4 )alkyl or Ar as defined above, phenyl, and 5 to 6 membered aromatic heterocycle containing 1 to 3 hetero atoms selected from the group consisting of O, N and S; and when Z is SO 2 R 3 or COR 3 , R 2 is carboxyl, NH 2 , NR(C 1 –C 4 )alkyl, N((C 1 –C 4 )alkyl) 2 or (C 3 –C 5 )cycloalkylamino; or a stereoisomeric form of the compound of formula (1) or formula (2), or mixtures of the stereoisomeric forms thereof in any ratio; or a pharmaceutically acceptable salt of the compound of formula (1) or formula (2).