Patent ID: 8653099

Claim:
A compound of Formula (I) wherein A is phenyl; provided that R 2 is other than 2-chloro, 2-C 1-4 alkoxy, 4-C 1-4 alkoxy, 2-C 1-4 alkoxycarbonyl, or 4-C 1-4 alkoxycarbonyl; or L is —N(R 3 )(CH 2 ) n —, and R 1 and L are attached to adjacent carbon atoms of phenyl, R 1 and R 3 are optionally taken with the atoms to which they are attached to form dihydro-indol-1-yl or dihydro-quinolin-1-yl; R 1 is one to three substituents selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkoxy, fluoro, chloro, and hydroxy; L is —Z —(CH 2 ) n — or —CH 2 —; n is 0 or 1; Z is O, S, or NR 3 ; provided that when Z is O or S, A is phenyl; R 2 is hydrogen, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethyl, chloro, fluoro, bromo, carboxy, or C 1-4 alkoxycarbonyl; R 3 is hydrogen or C 1-3 alkyl; R 4 is hydrogen or C 1-4 alkyl; R 5 is isoquinolinyl and quinolinyl; wherein R 5 is optionally substituted with 1 to 2 substituents independently selected from the group consisting of C 1-4 alkyl, hydroxy, C 1-4 alkoxy, trifluoromethyl, chloro, fluoro, bromo, carboxy, C 1-4 alkoxycarbonyl, and cyano; or an enantiomers, a diastereomer, or a pharmaceutically acceptable salt thereof; provided that a compound of Formula (I) is other than a compound wherein A is phenyl, R 1 is 3-chloro, R 2 is 4-trifluoromethyl, L is —Z—(CH 2 ) n —, n is 1, Z is NR 3 , R 3 is hydrogen, R 4 is hydrogen, and R 5 is isoquinolin-5-yl; and a compound wherein A is phenyl, R 1 is 4-methoxy, R 2 is 4-chloro, L is —Z—(CH 2 ) n —, n is 0, Z is NR 3 , R 3 is hydrogen, R 4 is hydrogen, and R 5 is isoquinolin-5-yl.