Patent ID: 8252744

Claim:
A drug delivery system comprising: an implantable drug infusion pump; and a stable suspension of an effective dosage of an appetite suppressing agent, the appetite suppressing agent comprising a polypeptide having the general formula: (Mp-Lk-V2-Hg—C H 2-C H 3) (t) (I) wherein Mp is an alpha melanocyte-stimulating hormone (α-MSH) peptide, Lk is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, C H 2 is an immunoglobulin heavy chain C H 2 constant region, C H 3 is an immunoglobulin heavy chain C H 3 constant region, and t is an integer of 1 to 10, wherein the appetite suppressing agent binds to a melanocortin receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.