Patent ID: 7985715

Claim:
A composition comprising: a support; and a region on the support comprising 2, 3, 4, 5, or 6 different building block molecules; each of the building block molecules being independently immobilized to the support; the region being a contiguous portion of the surface of the solid support with the different building block molecules distributed randomly throughout the contiguous region; 2 or more of the different building block molecules together forming a candidate artificial receptor, a lead artificial receptor, a working artificial receptor, or a combination thereof; one or more of the building block molecules is a peptide of formula: R 1 R 2 NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)—R 6 (SEQ ID NO:133), Tether-R 1 NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)—R 6 (SEQ ID NO:133), R 1 R 2 NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)-Tether (SEQ ID NO:133), Linker-R 1 NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)—R 6 (SEQ ID NO:133), or R 1 R 2 NH—Z-Ala-Gly-Ala-Gly-X-Ala-Y—C(O)-Linker (SEQ ID NO:133); in which: R 1 and R 2 are hydrogen or R 1 is hydrogen and R 2 is R 7 (O)C—, in which R 7 is unsubstituted C1 to C6 alkyl, substituted C1 to C6 alkyl, aryl, or substituted aryl; Z is lysine; X and Y are independently arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine; R 6 is hydrogen or —XR 10 , in which X is a heteroatom and R 10 is unsubstituted C1 to C6 alkyl, substituted C1 to C6 alkyl, aryl, or substituted aryl; the tether is a polyethylene glycol, a polyamide, a linear polymer, an oligosaccharide, or a polysaccharide; the tether being covalently coupled to the peptide and to the support; the linker is an unsubstituted alkyl, substituted alkyl, cycloalkyl, heterocyclic, substituted heterocyclic, aryl alkyl, aryl, heteroaryl, heteroaryl alkyl, ethoxy or propoxy oligomer, or glycoside moiety; substituted with a carboxyl, alcohol, phenol, thiol, amine, carbonyl, or maleimide group; the linker being covalently coupled to the peptide and to the support.