Patent ID: 8129423

Claim:
A compound of formula (III): wherein R 1 is a) bornyl, norbornyl, adamantyl or adamantyl substituted with one or two substituents independently selected from hydroxy, alkoxy, halogen, alkyl, hydroxyalkyl, amino, aminocarbonyl, alkoxycarbonyl, hydroxycarbonyl, alkylcarbonylamino, alkyl-S(O) 2 -amino, haloalkyl-S(O) 2 -amino, alkoxycarbonylamino-S(O) 2 -amino, amino-S(O) 2 -amino, hydroxyalkylcarbonylamino, aminocarbonylamino and haloalkoxy; b) trifluoromethylphenyl, methoxyphenyl, haloalkoxyphenyl or difluorophenyl, wherein trifluoromethylphenyl, haloalkoxyphenyl and difluorophenyl are optionally substituted with one or two substituents independently selected from alkyl, halogen, haloalkyl, alkoxy, hydroxy and haloalkoxy; c) trifluoromethylphenylalkyl or trifluoromethylphenylalkyl substituted with one or two substituents independently selected from alkyl, halogen, haloalkyl, alkoxy, hydroxy and haloalkoxy; d) phenylcycloalkyl or phenylcycloalkyl substituted with one to three substituents independently selected from alkyl, halogen, haloalkyl, alkoxy, hydroxy and haloalkoxy; e) cyanophenyl or cyanophenyl substituted with halogen; or f) dihalophenyl, aminocarbonylphenyl or hydroxyphenyl, wherein aminocarbonylphenyl and hydroxyphenyl are optionally substituted with one or two substituents independently selected from alkyl, halogen, haloalkyl, alkoxy and haloalkoxy; R 2 is hydrogen, alkyl, alkenyl, haloalkyl, pyridinylalkyl, cycloalkyl, cycloalkylalkyl or phenylalkyl or R 2 is pyridinylalkyl or phenylalkyl which both are substituted with one to three substituents independently selected from alkyl, hydroxy, alkoxy, halogen, haloalkyl and haloalkoxy; one of R 3 and R 4 is cycloalkyl and the other one is a) hydrogen, alkyl, pyridinyl, cycloalkyl, cycloalkylalkyl or haloalkyl; b) phenyl or phenyl substituted with one to three substituents independently selected from fluoro, chloro, bromo, haloalkyl, alkoxy, hydroxy, haloalkyl and haloalkoxy; c) phenylalkyl or pyridinylalkyl, wherein phenylalkyl and pyridinylalkyl are optionally substituted with one to three substituents independently selected from alkyl, halogen, haloalkyl and hydroxy; d) oxetane or oxetane substituted with alkyl; e) naphthyl or tetrahydronapthyl; f) phenylalkoxyalkyl or phenylalkoxyalkyl substituted with one to three substituents independently selected from alkyl and halogen; g) hydroxyalkyl; or h) pyridinyloxyalkyl or pyridinyloxyalkyl substituted with cyano; one of R 5 and R 6 is hydrogen, isopropyl, isobutyl, cycloalkyl or haloalkyl and the other one is hydrogen; and pharmaceutically acceptable salts and esters thereof.