Patent ID: 8575201

Claim:
A compound of formula I: wherein: R 1 and R 2 together with the carbon atom to which they are attached form a C 3-10 carbocyclic ring or a 5-11 membered heterocyclic ring, wherein each carbocycle or heterocycle is optionally independently substituted with one to two groups selected from C 1-6 alkyl and halogen; R 3 is 5-11 membered heteroaryl ring containing one to three heteroatoms selected from nitrogen, oxygen and sulfur, wherein each R 3 is optionally independently substituted with one to three groups selected from C 1-5 alkyl, C 1-5 alkoxy, C 1-3 alkylhydroxy, —CN, amino, C 1-3 alkylamino and C 1-3 dialkylamino; R 4 is hydrogen, halogen, C 1-3 alkyl or nitrile; R 5 is C 1-6 alkyl, C 3-10 carbocycle, 5-11 membered heterocycle, aryl, 5-11 membered heteroaryl, —C(O)—R 6 or —NR 7 R 8 , wherein each R 5 is optionally independently substituted with one to three groups selected from R 9 , R 10 and R 11 ; R 6 is C 3-8 heterocycle, amino, C 1-3 alkylamino, C 1-3 dialkylamino or —NH-5-6 membered heterocycle, each optionally independently substituted with one to three groups selected from R 9 , R 10 and R 11 ; R 7 and R 8 are each independently hydrogen, —S(O) n C 1-6 alkyl or C 1-6 alkyl; R 9 , R 10 and R 11 are independently selected from (a) —H, (b) —OH, (c) halogen, (d) —CN, (e) —CF 3 , (f) C 1-6 alkyl optionally substituted with one to three —OH, —N(R 12 )(R 13 ), aryl, —O—C 1-2 alkyl-aryl, 3-6 membered heterocycle, —C(O)-3-6 membered heterocycle, C 1-6 alkoxy, —S(O) n C 1-6 alkyl, —CO 2 R 12 , halogen, —CN or —C(O)N(R 12 )(R 13 ), (g) C 1-6 alkoxy, (h) —N(R 12 )(R 13 ), (i) —S(O) n C 1-6 alkyl, (j) —CO 2 R 12 , (k) —C(O)N(R 12 )(R 13 ), (l) —S(O) 2 N(R 12 )(R 13 ), (m) a 3-10 membered heterocyclic group optionally substituted with one to three groups selected from —OH, C 1-6 alkyl, C 1-6 alkylhydroxy, C 1-6 alkyl-CO 2 R 12 , —S(O) n C 1-6 alkyl, oxo, —C(O)N(R 12 )(R 13 ), and —CO 2 R 12 , (n′) oxo, (o) —C(O)—C 1-3 alkyl, (p) —C(O)-3-6 membered heterocycle optionally substituted with one to three groups selected from halogen hydroxy and C 1-6 alkoxy, (q) —OR 12 , (r) 5-11 membered heteroaryl; R 12 and R 13 are each independently selected from —H, —C 1-6 alkyl, —C(O)—C 1-6 alkyl, C 3-10 carbocycle and a 3-6 membered heterocyclic group, each of which is optionally independently substituted with one to three —OH, C 1-6 alkyl, C 1-6 alkoxy, —C(O)N(R 14 )(R 15 ), —S(O) n C 1-6 alkyl, CN, C 3-10 carbocycle, —CO 2 R 14 , CF 3 , 3-6 membered heterocycle, halogen; or R 12 and R 13 together with the nitrogen atom to which they are attached form a heterocyclyl ring optionally substituted with one to three —OH, CN, C 1-6 alkoxy or oxo; R 14 and R 15 are each independently selected from —H and —C 1-6 alkyl; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.