Patent ID: 7514422

Claim:
A method of decreasing food intake, inducing satiety, or controlling weight gain; or of treatment of a disorder selected from schizophrenia, anxiety, and obesity; in a patient in need thereof, comprising administering to said patient a pharmaceutically effective amount of a compound of Formula (I): wherein: R 1 is H or C 1-8 alkyl; R 2 is C 1-8 alkyl, —CH 2 —O—C 1-8 alkyl, —C(═O)—O—C 1-8 alkyl, —C(═O)—NH—C 1-8 alkyl, OH, or CH 2 OH; R 2a is H; or R 2 and R 2a together form —CH 2 —CH 2 —; R 3 and R 4 are each independently H, halogen, perhaloalkyl, CN, OR 5 , SR 5 , NHR 5 , N(R 5 ) 2 , OH, aryl, or heteroaryl, wherein said aryl can be optionally substituted with up to two substituents selected from C 1-8 alkyl, halogen, perhaloalkyl, and alkoxy, and said heteroaryl can be optionally substituted with up to two substituents selected from halogen and C 1-8 alkyl; or R 3 and R 4 together with the atoms to which they are attached can form a 5- or 6-member heterocyclic ring having one O atom; each R 5 is independently C 1-8 alkyl, C 1-8 alkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl or perhaloalkyl, or allyl; and R 6 is H or C 1-8 alkyl; or a pharmaceutically acceptable salt, solvate or hydrate thereof; provided that: (A) if R 2 is methyl and R 1 and R 3 are both H, then R 4 is not thiazole, substituted thiazole or a thiazole derivative: (B) if R 6 is other than H, then neither R 3 nor R 4 can be H; (C) if R 1 and R 2 are methyl, and R 4 is H, then R 3 cannot be NHR 5 or N(R 5 ) 2 ; (D) if R 1 and R 2 are methyl, and R 4 is H, then R 3 cannot be imidazole, substituted imidazole, or an imidazole derivative; and (E) if R 3 is OH, and R 1 is methyl then R 2 cannot be cyclopentyl, —CH 2 -cyclohexyl, cyclopropylmethyl, or cyclohexyl.