Patent ID: 8334272

Claim:
A method for increasing nucleic acid expression in cells comprising: a) providing: i) a gene transfer system, wherein said gene transfer system comprises lipids, ii) a specific inhibitor of major tubulin deacetylase 6 (HDAC6), wherein said specific inhibitor inhibits HDAC6 without inhibiting other HDACs, iii) mammalian cells, and iv) a vector, and b) contacting said cells with said vector and said specific inhibitor of HDAC6 in the presence of said gene transfer system such that gene expression from said vector is increased at least 2.5 fold in the presence of said specific inhibitor of HDAC6 compared to expression when said specific inhibitor of HDAC6 is absent, wherein said cells are contacted with said specific inhibitor of HDAC6 together with, or immediately after said contacting with, said vector.