Patent ID: 7635695

Claim:
A compound having the formula (Ia.1): or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of —C(O)NR 1a R 1b , —C(O)R 1a , —CH(═NOH), —N(R 1b )C(O)R 1a , —SO 2 NR 1a R 1b , —SO 2 R 1a , —C(O)N(R 1a )OR 1b , —(C 1 -C 4 )alkylene-N(R 1b )C(O)R 1a , and —(C 1 -C 4 )alkylene-C(O)NR 1a R 1b ; wherein R 1a and R 1b are selected from hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 6 )heteroalkyl, hydroxy(C 1 -C 4 )alkyl, fluoro(C 1 -C 4 )alkyl, cyano(C 1 -C 4 )alkyl, cyclo(C 3 -C 8 )alkyl, and mono- or di-hydroxycyclo(C 3 -C 8 )alkyl; R 2 is selected from the group consisting of —C(O)NR 2a R 2b and —OH; wherein R 2 a and R 2b are selected from hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 6 )heteroalkyl, mono- or di-hydroxy(C 1 -C 4 )alkyl, fluoro(C 1 -C 4 )alkyl, cyano(C 1 -C 4 )alkyl, cyclo(C 3 -C 8 )alkyl, mono- or di-hydroxycyclo(C 3 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, —C(O)—(C 1 -C 4 )alkyl, —C(O)—(C 1 -C 4 )alkoxy, and C(O)-fluoro(C 1 -C 4 )alkyl; L is a single bond; Q is selected from the group consisting of(C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, aryl, aryl(C 1 -C 4 )alkyl, cyclo(C 3 -C 8 )alkyl, and cyclo(C 5 -C 8 )alkenyl, wherein each of the moieties is optionally further substituted, X 1 , X 2 and X 3 are independently selected from the group consisting of ═C—, and —CH—; Y 2 is —S(O) m —; Y 1 and Y 3 are independently selected from the group consisting of ═C(R 5a )—, and —C(R 5 )(R 6 )—; Y 4 is ═N— or —N(R 5 )—; Z 1 and Z 2 are independently CH, or ═C—; each R 5 and R 6 is independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, cyclo(C 3 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, hetero(C 1 -C 6 )alkyl, and arylhetero(C 1 -C 4 )alkyl; each R 5a is independently selected from the group consisting of hydrogen, halogen, (C 1 -C 6 )alkyl, cyclo(C 3 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, hetero(C 1 -C 6 )alkyl, and arylhetero(C 1 -C 4 )alkyl; and the subscript m is 0; with the proviso that said compound is other than