Patent ID: 8106090

Claim:
A compound of the formula III: wherein A is R1 is H or halo; R2 and R3 are H; R4 is H or halo; X is CH; R6 is H; R7 is H or C 1 -C 6 alkyl; R8 is C 1 -C 6 alkyl, C 1 -C 6 alkylaryl, C(O)R9 and —SO 2 R9, or R7 and R8 combine to form R9 is selected from C 1 -C 6 alkyl, aryl, and C 1 -C 6 alkylaryl, R5 is H; Y is selected from —CH 2 —Y′—, —CH 2 —CH 2 —Y′—, —Y′—CH 2 —, —Y′—CH 2 —CH 2 — and —CH 2 —Y″—CH 2 —; Y′ is selected from CR11 and CR15; Y″ is selected from CR11, CR15, NR16, and O; W is CR10; R10 is selected from H, —C(O)NR13R14, aryl, C 1 -C 6 alkyl-O—C 1 -C 6 alkyl and hydroxy C 1 -C 6 alkyl; R11 and R12 are independently selected from H C 1 -C 6 alkyl, and aryl; R13 and R14 are independently selected from H and C 1 -C 6 alkyl; R15 combines with R11 or R12 to form a phenyl ring; R16 combines with R11 or R12 to form a 5-6 membered heteroaryl ring optionally substituted with CF 3 ; where R10, is aryl optionally substituted with F; Het is a N-linked 5-membered heteroaryl ring optionally substituted with aryl, or a N-linked 5-membered heteroaryl ring fused with phenyl; with the proviso that a compound of formula III is not 1-(3-Amino-2-hydroxy-4-phenyl-butyl)-pyrrolidine-2-carboxylic acid (2-pyridin-2-yl-ethyl)-amide.