Patent ID: 7071298

Claim:
A compound having the structural formula: wherein X is a divalent moiety selected from the group consisting of —NR′-, —S(O)—, —S(O) 2 —, or —O—, R′ being selected from the group consisting of H, and linear or branched chain alkyl group (C 1 –C 4 ) and an unsubstituted or substituted aryl group (C 6 –C 10 ) and an aralkyl group (C 7 –C 10 ); R is a substituent selected from the group consisting of H, an amino acid residue, said amino acid including said NR′ moiety, a polyaminoacid residue said polyamino acid including said NR′ moiety, a peptide chain, a linear or branched chain aliphatic group (C 1 –C 8 ), which is unsubstituted or substituted with at least one nitrogen or oxygen-containing substituent, a linear or branched chain aliphatic group (C 1 –C 8 ), which is unsubstituted or substituted with at least one nitrogen- or oxygen-containing substituent and interrupted by at least one —O—, —NH—, or —NR″- moiety, R″ being linear or branched chain alkyl (C 1 –C 6 ) and an unsubstituted or substituted aryl group (C 6 –C 10 ) or aralkyl group (C 7 –C 10 ), with the proviso that when X represents —NR′-, R and R′, together with the nitrogen atom to which they are attached, may also represent a substituted or unsubstituted heterocyclic ring having from 5 to 7 ring atoms, with at least one of nitrogen and oxygen being the only heteroatoms in said ring, said aryl group (C 6 –C 10 ) or aralkyl group (C 7 –C 10 ), and said heterocyclic ring substituents being selected from the group consisting of H, alkyl (C 1 –C 6 ), halogen, CF 3 , CN and —O-alkyl (C 1 –C 6 ); R 1 is a polyol moiety having 1 to 4 linear carbon atoms; Y is a hydroxymethylene moiety —CHOH—; Z is selected from the group consisting of —H, O-alkyl (C 1 –C 6 ), -halogen, —CF 3 , —CN, —COOH and —SO 3 H 2 ; or its pharmaceutically acceptiable salt or its stereoisomer, except that X—R in the above formula does not represent hydroxyl or thiol.