Patent ID: 6974823

Claim:
A pharmaceutical composition comprising (i) an effective amount of a compound of the formula: where each X independently is O, S, or NR 2 ; R 2 is selected from the group consisting of cyano, nitro, hydrogen, C 1 -C 4 alkyl, hydroxy, and C 1 -C 4 alkoxy; D is a direct bond or C 1 -C 8 alkyl or alkenyl; R is an alicyclic or aromatic, mono-, bi- or tricyclic, carbo- or heterocyclic ring, wherein when R is an alicyclic monocyclic heterocyclic ring containing a nitrogen heteroatom, the alicyclic monocyclic heterocyclic ring contains only one nitrogen heteroatom; wherein R is optionally substituted with one substituent selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, C 1 -C 6 straight or branched chain alkyl, C 2 -C 6 straight or branched chain alkenyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyloxy, phenyl, phenoxy, benzyloxy, and amino; or a pharmaceutically acceptable salt, ester, or solvate thereof; (ii) an additional neurotrophic factor; and (iii) a pharmaceutically acceptable carrier.