Patent ID: 8753659

Claim:
An intravascular stent comprising a metal body having a coating comprising a polymer and a restenosis inhibiting agent, wherein: the restenosis inhibiting agent is a sparingly water soluble matrix metallo-proteinase inhibitor (MMPI); and the polymer is a cross-linked amphiphilic polymer formed from a cross-linkable polymer of formula: wherein: B is a straight or branched alkylene, alkyleneoxaalkylene or alkylene oligo-oxaalkylene chain optionally containing one or more fluorine atoms or, if X contains a terminal carbon atom bonded to B, a valence bond; B 2 is a straight or branched alkylene, oxaalkylene or oligo-oxaalkylene chain optionally containing one or more fluorine atoms up to and including perfluorinated chains, or B 2 is a valence bond; A is —O— or —NR 1 —; A 1 is —O— or —NR 15 —; A 2 is —O— or —NR 22 —; D is a non-ionic alkyl(alk)acrylate or hydroxyalkyl(alk)acrylate; R is hydrogen or a C 1 -C 4 alkyl group; R 14 is hydrogen or a C 1 -C 4 alkyl group; R 21 is hydrogen or C 1-4 alkyl; X is a zwitterionic group; R 13 is a straight or branched alkyl, alkoxyalkyl or oligoalkoxyalkyl chain containing four or more carbon atoms unsubstituted or substituted by one or more fluorine atoms optionally containing one or more carbon double or triple bonds, or R 13 is —(C(R 18 ) 2 ) qq (Si(R 19 ) 2 )(OSi(R 18 ) 2 ) pp R 19 ; R 20 is selected from the group consisting of ethylenically and acetylenically unsaturated group containing radicals; aldehyde groups; silane and siloxane groups containing one or more substituents selected from halogen atoms and C 1-4 -alkoxy groups; hydroxyl; amino; carboxyl; epoxy; —CHOHCH 2 Hal; succinimido; tosylate; triflate; imidazole carbonyl amino; optionally substituted triazine groups; acetoxy; mesylate; carbonyl di(cyclo)alkyl carbodiimidoyl; isocyanate, acetoacetoxy; and oximino; R 1 is hydrogen or a C 1 -C 4 alkyl group or R 1 is —B—X; R 15 is hydrogen, a C 1 -C 4 alkyl group or R 13 ; R 22 is hydrogen, a C 1 -C 4 alkyl group, or B 2 R 20 ; each R 18 is the same or different and is hydrogen or alkyl of 1 to 4 carbon atoms, or aralkyl; each R 19 is alkyl of 1 to 4 carbon atoms; Hal is selected from chlorine, bromine and iodine atoms; qq is from 1 to 6; pp is from 0 to 49; l is 1 to 75; m is 0 to 99; n is 0 to 33; i is about 15; and n+m is 25 to 99.