Patent ID: 7393960

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: wherein X is selected from the group consisting of a bond, O, S(O) n , CH 2 , and C 3-6 cycloalkylidene; Y is selected from the group consisting of —OCR 7 R 8— , and —CH 2 CR 5 R 6— ; Z is selected from the group consisting of —CO 2 H and tetrazole; A is selected from the group consisting of H, C 1-4 alkyl, C 1-4 alkenyl, —OC 1-4 alkyl, and halogen, wherein alkyl, alkenyl, and Oalkyl are optionally substituted with 1-5 halogens; R 5 , R 6 , R 7 , and R 8 are each independently selected from the group consisting of H, halogen, C 1 -C 5 alkyl, OC 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkenyl, C 3-6 cycloalkyl, (CH 2 ) 0-2 phenyl, —O(CH 2 ) 0-2 phenyl and CO 2 H, wherein C 1 -C 5 alkyl, OC 1 -C 5 alkyl, C 2 -C 5 alkenyl, OC 2 -C 5 alkenyl, C 3-6 cycloalkyl, and phenyl are optionally substituted with 1-5 halogens, and C 3-6 cycloalkyl and phenyl are further optionally substituted with 1-3 groups independently selected from C 1 -C 3 alkyl and OC 1 -C 3 alkyl, said C 1 -C 3 alkyl and OC 1 -C 3 alkyl being optionally substituted with 1-3 halogens; R 2 is C 1 -C 4 alkyl, which is optionally substituted with 1-5 halogens; R 3 is 3-benzisoxazolyl optionally substituted with 1-3 groups independently selected from halogen, C 1-3 alkyl, and OC 1-3 alkyl, wherein C 1-3 alkyl and OC 1-3 alkyl are optionally substituted with 1-5 halogens; each R 4 is independently selected from the group consisting of halogen, C 1 -C 3 alkyl, and OC 1 -C 5 alkyl, whcrein C 1 -C 3 alkyl and OC 1 -C 5 alkyl are optionally substituted with 1-5 halogens; n is an integer from 0-2; p is an integer from 0-3; and q is an integer from 0-3.