Patent ID: 7659368

Claim:
An isolated recombinant chimeric heteromultimer adhesin comprising: a first amino acid sequence comprising the extracellular domain of the ErbB2 receptor monomer, and a first heterologous multimerization domain; an additional amino acid sequence comprising the extracellular domain of the ErbB3 receptor monomer and a second heterologous multimerization domain; wherein the first amino acid sequence and the additional amino acid sequence are brought together via interaction of the multimerization domain of the first amino acid sequence and the multimerization domain of the additional amino acid sequence to form a monovalent ligand binding domain of the chimeric heteromultimer adhesin having a higher affinity for a ligand relative to a monomer of either receptor or a homomultimer of either receptor; and wherein the chimeric heteromultimer adhesin is soluble in an aqueous solution.