Patent ID: 8088814

Claim:
A method for the treatment of schizophrenia comprising administering to a subject in need an effective amount of a selective COX-2 inhibitor or prodrug thereof, wherein the selective COX-2 inhibitor is a selective COX-2 inhibitor of the following formula IV: wherein Z is selected from the group consisting of partially unsaturated or unsaturated heterocyclyl and partially unsaturated or unsaturated carbocyclic rings; R 1 is selected from the group consisting of methyl or amino; and R 2 is selected from the group consisting of heterocyclyl, cycloalkyl, cycloalkenyl and aryl, wherein R 2 is optionally substituted at a substitutable position with one or more radicals selected from alkyl, haloalkyl, cyano, carboxyl, alkoxycarbonyl, hydroxyl, hydroxyalkyl, haloalkoxy, amino, alkylamino, arylamino, nitro, alkoxyalkyl, alkylsulfinyl, halo, alkoxy and alkylthio; and R 3 is selected from the group consisting of a radical selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, oxygen, cyano, carboxyl, cyanoalkyl, alkyloxy, alkylthio, alkylcarbonyl, haloalkyl, alkylthioalkyl, hydroxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonylalkyl, alkylaminocarbonyl, alkylaminocarbonylalkyl, carboxyalkyl, alkylamino, aminoalkyl, alkylaminoalkyl, alkylsulfinyl, alkylsulfonyl, aminosulfonyl, and alkylaminosulfonyl.