Patent ID: 8445680

Claim:
A compound of formula I and pharmaceutically acceptable salts thereof wherein R 8 is selected from hydrogen, C 1-6 alkyl, optionally substituted with a hydroxy, —SH, —NH 2 or —CO 2 H, and C 3-6 cycloalkyl optionally substituted with a hydroxy, —SH, —NH 2 or —CO 2 H; n is 1 or 2; one of X or Y is —S(O) n , and the other is CR 4 R 5 ; R 1 is selected from —C 1-10 alkyl, —C 2-10 alkenyl, —C 5-10 cycloalkenyl, —C 2-10 alkynyl, —C 0-10 alkylaryl, —C 0-10 alkylheterocyclyl; —C 0-10 alkyl-C 0-10 cycloalkyl, and perfluoroC 1-6 alkyl; wherein in R 1 said alkyl, alkenyl, alkynyl, cycloalkenyl, aryl, heterocycloalkyl, heterocyclyl, and cycloalkyl are each optionally substituted with one or more R 9 substituents; R 2 and R 3 are independently selected from hydrogen, phenyl, heterocyclyl, and —C 1-10 alkyl, wherein C 1-10 alkyl is unsubstituted or substituted with one or more fluorine atoms, and phenyl is unsubstituted or substituted with or more substituents selected from fluoro, chloro, hydroxyl, C 1-10 alkyl, and —OC 1-10 alkyl; R 4 , R 5 , R 6 , and R 7 are independently selected from hydrogen, cyano, oxo, —C 1 -C 10 alkyl, —C 2-10 alkenyl, —C 3-10 cycloalkyl, —(C 1-10 alkyl)aryl, (C 0-10 alkyl)heterocyclyl, —C 5-10 cycloalkenyl, —C 2-10 alkynyl, —SO n (C 1-10 alkyl) and —SO n aryl wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, and heterocyclyl are optionally substituted by one or more substituents R 9 , and optionally one set of substituents, R 4 and R 5 , or R 6 and R 7 , are linked together to form a ring of 5 to 8 atoms optionally substituted with one or more substituents R 9 ; where said ring is partially or fully unsaturated having 0, 1 or 2 heteroatoms independently selected from —NR 6 —, —O— and —S(O) n —; R 9 is selected from halogen, hydroxy, oxo, cyano, aryl, heterocyclyl, —C 1-6 alkyl, —C 1-6 alkoxy, aryloxy, heterocyclyloxy, —CO 2 R a , —NR b R c , —CONR b R c , —OCO 2 R a , —OCONR b R c , —NR d CO 2 R a , —NR d CONR b R c , —SC 0-6 alkyl and —S(O) n R d , wherein said aryl, heterocyclyl, alkoxy, aryloxy, heterocyclyloxy are optionally substituted by one or more substituents R 10 ; R 10 is selected from hydroxy, aryl, heterocyclyl, halogen, —C 1-6 alkyl, C 1-6 alkoxy, halogen, CO 2 H, cyano, O(C═O) 0-1 C 1-6 alkyl, NO 2 , trifluoromethoxy, trifluoroethoxy, —O (0-1) (C 1-10 )perfluoroalkyl, C 0-10 alkylaminocarbonylamino, C 0-10 alkyloxycarbonylaminoC 0-10 alkyl, C 0-10 alkylcarbonylaminoC 0-10 alkyl, C 0-10 alkylaminosulfonylaminoC 0-10 alkyl, C 0-10 alkylsulfonylaminoC 0-10 alkyl, C 0-10 alkylsulfonyl, C 0-10 alkylaminosulfonyl, C 0-10 alkylaminocarbonyl, —(C═O)N(C 0-6 alkyl) 2 , —S(C 0-6 alkyl), and NH 2 ; R a is chosen from hydrogen; —C 1-10 alkyl, —(C 1-6 alkyl)C 3-8 cycloalkyl; and —(C 1-6 alkyl)phenyl; and R b , R c , and R d are each independently chosen from hydrogen, —C 1-10 alkyl, —C 3-10 cycloalkyl, aryl, and heterocyclyl, wherein said alkyl, cycloalkyl, aryl and heterocyclyl are optionally substituted by one or more substituents R 10 .