Patent ID: 8809264

Claim:
A compound of Formula I: as well as the pharmaceutically acceptable salts thereof, wherein: A is selected from H, —(C═O)—O—R 1 , —(C═O)—R 2 , —C(═O)—NH—R 2 , or —S(O) 2 —R 1 , —S(O) 2 NHR 2 ; each R 1 is independently selected from the group consisting of: (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; (iii) —C 1 -C 8 alkyl, —C 2 -C 8 alkenyl, or —C 2 -C 8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted —C 1 -C 8 alkyl, substituted —C 2 -C 8 alkenyl, or substituted —C 2 -C 8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; —C 3 -C 12 cycloalkyl, or substituted —C 3 -C 12 cycloalkyl; —C 3 -C 12 cycloalkenyl, or substituted —C 3 -C 12 cycloalkenyl; each R 2 is independently selected from the group consisting of: (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; (iv) —C 1 -C 8 alkyl, —C 2 -C 8 alkenyl, or —C 2 -C 8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted —C 1 -C 8 alkyl, substituted —C 2 -C 8 alkenyl, or substituted —C 2 -C 8 alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; —C 3 -C 12 cycloalkyl, or substituted —C 3 -C 12 cycloalkyl; —C 3 -C 12 cycloalkenyl, or substituted —C 3 -C 12 cycloalkenyl; G is selected from-NHS(O) 2 —R 3 ; where each R 3 is independently selected from: (i) heterocycloalkyl or substituted heterocycloalkyl; and (ii) C 3 -C 12 cycloalkyl, or substituted —C 3 -C 12 cycloalkyl; —C 3 -C 12 cycloalkenyl, or substituted —C 3 -C 12 cycloalkenyl; L is selected from —CH 2 —, —O—, —S—, or —S(O) 2 —; X and Y taken together with the carbon atoms to which they are attached to form a cyclic moiety selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; W is absent; Z is selected from the groups consisting of: (vi) aryl, substituted aryl; (vii) heteroaryl, substituted heteroaryl; (viii) —C 3 -C 12 cycloalkyl, substituted —C 3 -C 12 cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl; (ix) —C 1 -C 6 alkyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; (x) —C 2 -C 6 alkenyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; (xi) —C 2 -C 6 alkynyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; j=0, 1, 2, 3, or 4; k=1, 2, or 3; m=0, 1, or 2; and denotes a carbon-carbon single or double bond.