Patent ID: 8501440

Claim:
An insulin analogue comprising a single chain polypeptide of formula I, B-C-A (I) wherein B comprises a polypeptide having the sequence: (SEQ ID NO: 33) FVNQHLCGSX 2 LVEALYLVCGERGFFYTX 3 X 4 T where X 2 is D or H, X 3 is P, D or K, and X 4 is K or P, wherein C is a polypeptide selected from the group consisting of: a polypeptide having the sequence GSEQRR (SEQ ID NO: 21), a polypeptide having the sequence GAGPRR (SEQ ID NO: 24), and a polypeptide having the sequence GPRR (SEQ ID NO: 25), and wherein A comprises a polypeptide having the sequence: (SEQ ID NO: 32) GIVEQCCX 1 SICSLYQLENYCN where X 1 is T or H.