Patent ID: 8329873

Claim:
A bispecific antibody comprising a first antibody joined to a second antibody, wherein: said first antibody comprises a VH domain comprising the C6B1D2 VH CDR1 sequence SYWIA (SEQ ID NO:59), the C6B1D2 VH CDR2 sequence LIYPGDSDTKYSPSFQG (SEQ ID NO:60), and the C6B1D2 VH CDR3 sequence HDVGYCTDRTCAKWPEWLGV (SEQ ID NO:61); and a VL domain comprising C6B1D2 VL CDR1 sequence SGSSSNIGNNYVS (SEQ ID NO:62), the C6B1D2 VL CDR2 sequence DHTNRPA (SEQ ID NO:63), and the C6B1D2 VL CDR3 sequence ASWDYTLSGWV (SEQ ID NO:64); and said second antibody comprises three VH CDRs and three VL CDRs of an antibody selected from the group consisting of HER3.F4 (SEQ ID NO:2), HER3.H1 (SEQ ID NO:3), HER3.H3 (SEQ ID NO:4), HER3.E12 (SEQ ID NO:5), HER3.B12 (SEQ ID NO:6), EGFR.E12 (SEQ ID NO:7), EGFR.C10 (SEQ ID NO:8), EGFR.B11 (SEQ ID NO:9), EGFR.E8 (SEQ ID NO:10), HER4.B6 (SEQ ID NO:19), and C6B1D2 (SEQ ID NOs:52 and 57).