Patent ID: 6884886

Claim:
A process for preparing a 6-aryl-4H-s-triazolo[3,4-c]-thieno [2,3-e]-1,4-diazepine of the formula I, wherein R 1 denotes a hydrogen or halogen atom or a C 1 -C 6 alkyl group, R 2 denotes a hydrogen or halogen atom or a C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, C 3 -C 6 cycloalkyl group or a 5- or 6-membered oxygen-, sulphur- or nitrogen containing heterocyclic group which may optionally be substituted at the nitrogen atom by a C 1 -C 3 alkyl group, and R 3 denotes a hydrogen or halogen atom, in which process, (a) a 5-aryl-1,3-dihydrothieno[2,3-e]-1,4-diazepine-2-one of the formula II wherein R 1 and R 3 are as herein defined, is treated with a chlorinating agent, to produce a corresponding 5-aryl-2-chlorothieno[2,3-e]-1,4-diazepine of the formula III wherein R 1 and R 3 are as herein defined, (b) the 5-aryl-2-chlorothieno[2,3-e]-1,4-diazepine of the formula III thus obtained is reacted with an acylhydrazine of the formula IV R2—CO—NH—NH2 (IV) wherein R 2 is as hereinbefore defined, and (c) the compound obtained in step (b) is treated with a base.