Patent ID: 7867998

Claim:
A method of relieving cough in a mammalian subject by administering to said subject a composition, comprising: an isolated compound with structure I or II: a pharmaceutically acceptable carrier, where in said base structure I: R 1 is selected from the group consisting of hydrogen, carbonyl, hydroxyl, methoxy and α-methyl-γ-butyrolactone; R 2 is selected from the group consisting of hydrogen, hydroxyl, methoxy and oxygen bridge to R 4 ; R 3 is selected from the group consisting of hydrogen, hydroxyl and methoxy; R 4 is hydrogen or oxygen bridge to R 2 ; and R 5 is hydrogen, hydroxyl or methoxy; and in said base structure II: R 1 is selected from the group consisting of hydrogen, carbonyl, hydroxyl, methoxy and α-methyl-γ-butyrolactone; R 2 is selected from the group consisting of hydrogen, methyl, ethyl and cyano; and R 3 and R 4 are each independently selected from the group consisting of H (hydrogen), ═O (carbonyl), and —O—C(═O)—C(CH 3 )═C—, which form monosubstituted spirolactone ring fused at C-11 (3-methyl-5H-furan-2-one), or —O—C(═O)—C(CH 3 )═C(OCH 3 )—, which form disubstituted lactone ring (4-methoxy-3-methyl-5H-furan-2-one) attached to C-11 by a double bond.