Patent ID: 8133728

Claim:
Isolated CD8+ T cells that are specifically cytotoxic for a target cell, wherein the target cell has on its surface one or more non tumor self antigenic peptides associated with Class 1 MHC molecules wherein said self antigenic peptides are peptides from human CD40L and are selected from the group consisting of: FELQPGASV (SEQ ID NO:40), QLTVKRQRL (SEQ ID NO: 41), QMIGSALFA (SEQ ID NO:42), SQAPFIASL (SEQ ID NO:43), ISMKIFMYL (SEQ ID NO:44), VTLENGKQLL (SEQ ID NO:45), VISEASSKT (SEQ ID NO:46), GVFELQPGA (SEQ ID NO:47), SMKIFMYLL (SEQ ID NO:48), and RQGLYYIYA (SEQ ID NO:49), and wherein the CD8+ T cells have been selectively activated by culturing said CD8+ T cells in the presence of antigen presenting cells (APCs) loaded with one or more of said self antigenic peptides from human CD40L.