Patent ID: 7129225

Claim:
A method for protecting against or treating hearing loss in a subject comprising administering an effective amount of a protein tyrosine kinase inhibitor having the formula: wherein R 1 through R 7 may be the same or different, and are selected from the group consisting of H, C(O)R a , C(O)NR a R b , C(O)OR a , C(O)SR a , OH, OR a , OC(O)R a , OC(O)OR a , NH 2 , NR a R b , NR a C(O)R b , NR a C(O)NR b R c , NR a C(O)OR b , NR a C(O)SR b , NR a S(O)R b , NR a S(O) 2 R b , NR a S(O)OR b , NR a S(O) 2 OR b , NR a P(O)OR b OR c , NR a P(O)OR b R c , NR a P(O)OR b OR c , SR a , S(O)R a , S(O) 2 R a , S(O)OR a , S(O) 2 OR a , S(O)NR a R b , S(O) 2 NR a R b , P(O)OR a OR b , B(OH) 2 , halogen, aryl, heteroaryl, biaryl, heterobiaryl, heterocyclic compound, and branched, cyclic, or unbranched alkyl, wherein R a , R b , and R c may be the same or different and are selected from the group consisting of H, aryl, heteroaryl, biaryl, heterobiaryl, and branched, cyclic, or unbranched alkyl; or R 5 and R 6 together form a heterocyclic compound; and wherein any of R 1 through R 7 and R a through R c is substituted or unsubstituted, to the subject to protect against or to treat hearing loss.