Patent ID: 8404731

Claim:
A method of treating type I diabetes, type II diabetes, or glucose intolerance comprising administering to a human a compound of Formula II(d) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are independently selected from the group consisting of hydrogen, fluoro, and chloro, wherein at least one of R 1 , R 2 , R 3 , R 4 , and R 5 is not hydrogen; R 20 is hydrogen; R 23 , R 24 , R 25 , R 26 , and, R 27 are independently selected from the group consisting of: hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, 1-ethyl-propyl, 1-propyl-butyl, 3,3-dimethyl-butyl, 4-methyl-pentyl, 4,4-dimethyl-pentyl, 1-(3,3-dimethyl-butyl)-4,4-dimethyl-pentyl, isobutyl, isopropyl, sec-butyl, tert-butyl, trifluoromethyl, 4,4,4-trifluorobutoxy, methoxy, ethoxy, propoxy, butoxy, pentoxy, hexyloxy, isobutoxy, isopropoxy, tert-butoxy, 2-phenethoxy, 2,2-dimethylpropoxy, 3-methyl-butoxy, 3,3-dimethyl-butoxy, phenethyloxy, 2-cyclohexyl-ethanesulfonyl, 3,3-dimethyl-butane-1-sulfonyl, cyclohexanesulfonyl, cyclohexylmethylsulfonyl, 2-cyclohexyl-ethanesulfinyl, 3,3-dimethyl-butane-1-sulfinyl, cyclohexylmethylsulfinyl, 2-cyclohexyl-ethylsulfanyl, 3,3-dimethyl-butylsulfanyl, phenethylsulfanyl, cyclohexylmethylsulfanyl, cyclopentyl, cyclohexyl, cyclopentyloxy, cyclohexyloxy, cyclopentylmethyl, cyclohexylmethyl, 2-cyclopentylethyl, 2-cyclohexylethyl, cyclopentylmethoxy, cyclohexylmethoxy, 2-cyclopentylethoxy, 2-cyclohexylethoxy, 2-cyclohexyl-vinyl, 3-ethyl-cyclobutyl, chloro, fluoro, and phenyl, wherein at least one of R 23 , R 24 , R 25 , R 26 , and R 27 is not hydrogen; G is wherein q is 2, D is C(R 7 )(R 8 ), E is N, and side f is a single bond wherein R 7 and R 8 are selected from the group consisting of: hydrogen and C 1-4 alkyl; M is hydrogen; r is 1, or a pharmaceutically acceptable salt thereof.