Patent ID: 8420616

Claim:
A method of modulating MAT II activity in a vertebrate subject, the method comprising administering to the vertebrate subject an effective amount of a substance capable of modulating expression of the MAT II β subunit in the vertebrate subject, wherein the substance comprises an RNA interference (RNAi) molecule directed to MAT II β subunit selected from the group consisting of short hairpin RNA (shRNA) and small interfering RNA (siRNA), wherein the shRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, and SEQ ID NO: 11 and wherein the siRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, and SEQ ID NO: 15, whereby modulation of MAT II activity is accomplished.