Patent ID: 7919095

Claim:
An isolated monoclonal antibody comprising: (a) a variable heavy chain region (VH) comprising: (i) a VH-CDR1 comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, and SEQ ID NO:55; (ii) a VH-CDR2 comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ NO:59, SEQ ID NO:60, SEQ ID NO:61, SEQ ID NO:97 and SEQ ID NO:101; (iii) a VH-CDR3 comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, and SEQ ID NO:98; and (b) a variable light chain region (VL) comprising: (i) a VL-CDR1 comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, and SEQ ID NO:79; (ii) a VL-CDR2 comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, and SEQ ID NO:85; (iii) a VL-CDR3 comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, and SEQ ID NO:96; wherein said antibody binds specifically to an IL-6 antigen.