Patent ID: 8138143

Claim:
A method of inducing migration of a progenitor cell or a progeny thereof to a site of neurological injury or damage in the central nervous system of a subject having neurological injury or damage, comprising: (a) administering a composition comprising a therapeutically effective amount of an exogenous TGF-α polypeptide to the subject, wherein the administration is parenteral, at an administration site outside the central nervous system and remote from the site of neurological injury or damage; (b) inducing proliferation of the progenitor cell or a progeny thereof to obtain proliferated cells; (c) inducing directed migration of proliferated cells to the site of neurological injury or damage; and (d) obtaining neurogenesis of functional neurons at or near the site of injury or damage, all of steps (b), (c) and (d) being evidenced by an amelioration of behavioral effects attributable to the injury or damage.