Patent ID: 8426388

Claim:
A method for inhibiting HIV protease activity in mammal comprising the step of administering to said mammal in need of such treatment a therapeutically effective amount of a compound or combination of compounds having formula (I), (II) or (III) wherein L 1 is a bond, —C(O)—, or —C(O)O—; wherein the carbonyl of the —C(O)O— moiety is attached to A of formula (I), (II) or (III); L 2 is —(CR 1 R 2 ) m —; m is 1, 2, 3, 4 or 5; R 1 at each occurrence is independently selected from the group consisting of hydrogen and C 1 -C 12 alkyl; R 2 at each occurrence is independently selected from the group consisting of hydrogen and C 1 -C 12 alkyl; R 3 is hydrogen, C 1 -C 12 alkyl or arylalkyl; R 4 is hydrogen, C 1 -C 12 alkyl or arylalkyl; q is 1 or 2; t is 1 or 2; M a is M 1 or M 2 ; M b is M 1 or M 2 ; M 1 is Na + , K + or + N(R 5 )(R 6 )(R 7 )(R 8 ); M 2 is Ca 2+ , Ba 2+ , Mg 2+ , Zn 2+ or + N(R 9 )(R 10 )(R 11 )(R 12 ), R 5 is hydrogen, alkyl, hydroxyalkyl, arylalkyl or-C(═NH)NH 2 ; R 6 is hydrogen, alkyl, hydroxyalkyl or arylalkyl; R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; alternatively, R 5 and R 6 , together with the nitrogen atom to which they are attached, form a piperidine ring; R 9 is -alkyl-N + (Z 1 )(Z 2 )(Z 3 ); R 10 is hydrogen, alkyl or arylalkyl; R 11 is hydrogen or alkyl; R 12 is hydrogen or alkyl; alternatively, R 9 and R 11 , together with the nitrogen atom to which they are attached, form a piperazine ring; Z 1 is hydrogen or alkyl; Z 2 is hydrogen or alkyl; Z 3 is hydrogen, alkyl or arylalkyl; and A is provided that when q is 1, M a is M 1 ; when q is 2, M a is M 2 ; when t is 1, M b is M 2 ; when t is 2, M b is M 1 ; and provided that when A is and L 1 is a bond, then L 2 is not —CH 2 —.