Patent ID: 7105668

Claim:
A compound having the following structure: wherein: R 1 is chosen from hydrogen, lower alkyl, substituted lower alkyl, benzyl, substituted benzyl, and naphthyl; R 2 and R 2 ′ are independently chosen from hydrogen, alkyl, oxaalkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, substituted alkyl, substituted aryl, substituted alkylaryl, substituted heteroaryl, and substituted alkylheteroaryl; provided that R 2 and R 2′ are different; R 4 is chosen from substituted benzyl, heterocyclyl and R 16 -alkylene-; R 5 , R 6 , R 7 and R 8 are independently chosen from hydrogen, alkyl, alkoxy, halogen, fluoroalkyl, nitro, dialkylamino, alkylsulfonyl, alkylsulfonamido, sulfonamidoalkyl, sulfonamidoaryl, alkylthio, carboxyalkyl, carboxamido, aminocarbonyl, aryl and heteroaryl; R 16 is chosen from alkoxy, amino, alkylamino, dialkylamino, N-heterocyclyl and substituted N-heterocyclyl; wherein the stereogenic center to which R 2 and R 2′ are attached is of the R configuration and wherein said compound has a chiral purity of >95%, or a pharmaceutically acceptable salt thereof.