Patent ID: 8759524

Claim:
A process for producing an optically active 3-quinuclidinol derivative represented by formula (III-1): wherein, R represents a hydrogen atom or an unsubstituted or substituted C7 to C18 aralkyl group, and * represents an optically active carbon atom, and ** represents an optically active carbon atom in the case R is other than a hydrogen atom, comprising: asymmetrically hydrogenating a 3-quinuclidinone derivative represented by formula (I-1): wherein, R is the same as previously defined in the presence of a ruthenium compound represented by the formula (II-2): Ru(X)(Y)(Px) n [R 1 H(NH 2 )C*-A-C*R 1 H(NH 2 )] (II-2) wherein, X and Y represent a hydrogen atom or a chlorine atom; Px represents a phosphine ligand selected from the group consisting of 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl and 2,2′-bis[bis(3,5-dimethylphenyl)phosphine]-1,1′-binaphthyl; n represents 1; R 1 represents an unsubstituted or substituted C1 alkyl group or an unsubstituted or substituted C6 aryl group; * is the same as previously defined; and, A represents an unsubstituted or substituted C1 to C3 alkanediyl group or an unsubstituted or substituted divalent heterocyclic group.