Patent ID: 8071575

Claim:
A compound of the formula or pharmaceutically acceptable salts or solvates thereof, wherein R T is wherein R T is connected to the compound at R 1 , R 2 , or R 4 ; wherein R 1 is hydrogen, lower alkyl, alkyl, aryl lower alkyl, aryl, or a covalent bond when R T is connected to the compound at R 1 ; R 2 is hydrogen, lower alkyl, alkyl, aryl lower alkyl, aryl, or a covalent bond when R T is connected to the compound at R 2 ; R 3 is hydrogen, lower alkyl, alkyl, aryl lower alkyl, aryl, or carbonyl-containing; R 4 is hydrogen, lower alkyl, alkyl, aryl lower alkyl, aryl, carbonyl-containing, or a covalent bond when R T is connected to the compound at R 4 ;. R 5 and R 6 are independently hydrogen, lower alkyl, or alkyl, or R 5 and R 6 , taken together with the carbon atoms to which they are bonded, form a ring containing about 6 to about 14 ring carbon atoms and up to a total of about 18 carbon atoms, which formed ring can be monocyclic, bicyclic, or tricyclic, wherein the ring can optionally have substituents, including heteroatoms; R 7 is hydroxy, lower alkoxy, or NR 8 R 9 ; R 8 and R 9 are independently hydrogen, or lower alkyl; wherein each R s is independently hydrogen, hydroxy, lower alkyl, or lower alkyl with heteroatoms; wherein D and G are independently covalent bond, carbonyl, epoxy, or anhydride; wherein E is covalent bond, (CT 2 ) r , where T is hydrogen, hydroxy, or lower alkyl, and where r is 0-8, or (C) r , where r is 2-8, and where the carbons are unsaturated or partially saturated with hydrogen; and wherein R A is hydrogen, hydroxyl, a protecting group, or a Bone Active Portion derived from a bone active agent.