Patent ID: 7927622

Claim:
A method for administering a pharmaceutical composition to a patient in need thereof, comprising: transnasally administering to the patient a pharmaceutical composition, the pharmaceutical composition comprising: an active ingredient; and a carrier comprising a penetrant suspended or dispersed in a solvent, the penetrant comprising a minute fluid droplet surrounded by a coating of at least one layer of at least two substances, the substances differing by at least a factor of 10 in solubility in an aqueous medium, the substances forming homoaggregates of one substance and/or heteroaggregates of the at least two substances, the average diameter of homoaggregates of the more soluble substance or the average diameter of the heteroaggregates of the at least two substances being smaller than the average diameter of homoaggregates of the less soluble substance, and/or the more soluble substance solubilizing the droplet and the content of the more soluble substance is up to 99 mol-% of the concentration required to solubilize the droplet or corresponds to up to 99 mol-% of the saturating concentration in an unsolubilized droplet, whichever is higher, and/or wherein the elastic deformation energy of the droplet surrounded by the coating is at least five times lower than the deformation energy of red blood cells or of a phospholipid bilayer having fluid aliphatic chains, and wherein the less soluble substance is a lipid and the more soluble substance is a surfactant or more soluble form of the lipid.