Patent ID: 7408067

Claim:
A compound represented by Formula (I) or pharmaceutically acceptable salts thereof: wherein: R 1 is —H, C 1-12 alkyl optionally substituted with 1, 2 or 3 groups independently selected from halogen, hydroxyl, thiol, C 1-4 alkoxy or C 1-4 alkylthio, or aryl-C1-4alkyl; R 2 is —H, —OH, —C(O)—NH 2 , —NH 2 , —NH-Q-V-T, wherein Q is —C(O)—, —C(O)—NH—, —C(O)O—, or —SO 2 —; V is H, aryl, aryl-C 1-12 alkyl, diaryl-C 1-12 alkyl, lactonyl, or C 1-18 alkyl optionally substituted with halogen, hydroxyl, C 1-4 alkoxy, —C(O)OC 1-4 alkyl, —OC(O)C 1-4 alkyl, aryl-C 1-4 alkoxy, aryloxy, or SO 2 C 1-4 alkyl; and T is H, halogen, C 1-5 alkyl, C 1-4 alkoxy, nitro, aryl, aryl-C 1-4 alkyl, or aryloxy unless V is H in which case T is absent; or linked back to the aromatic ring so as to form a fused bicyclic compound represented by Formula (Ia) wherein D is O or S; and E is O, S, NR 5 , C(R 5 ) 2 , O—CR 5 2 , NR 5 —CR 5 2 , NR 5 —CO, CR 5 2 —O, CR 5 2 —S(O) r , CR 5 2 —NR 5 , CR 5 2 —CR 5 2 , CO—NR 5 , or CR 5 ═CR 5 ; unless X is N in which case R 2 is absent R 3 is H, halogen, C 1-4 alkyl optionally substituted with from 1 to 3 fluorine atoms, cyano, CF 3 , OC 1-4 alkyl, aryloxy, arylC 1-4 alkyl, arylC 1-4 alkoxy, C 3-10 cycloalkoxy, carboxy, carbonamido, —CO—, —CO 2 H, —NH 2 , NH—C 1-4 alkyl, aryl, hydroxy, —SO 2 NH 2 , —SO 2 NHC 1-4 alkyl, or —C 1-4 alkyl-OH; R 4 is H, halogen, C 1-4 alkyl optionally substituted with from 1 to 3 fluorine atoms, cyano, CF 3 , OC 1-4 alkyl, aryloxy, arylC 1-4 alkyl, arylC 1-4 alkoxy, C 3-10 cycloalkoxy, carboxy, carbonamido, —CO—, —CO 2 H, —NH 2 , NH—C 1-4 alkyl, aryl, hydroxy, —SO 2 NH 2 , —SO 2 NHC 1-4 alkyl, or —C 1-4 alkyl-OH; R 5 is each independently H or C 1-4 alkyl; X is C or N; W is C or N; W′ is C or N; Y is C or N; Y′ is C or N; provided that there are no more than two N atoms in the aryl ring; m is 2; n is 2; and provided that when X, W, W′, Y and Y′ are all C and R 3 and R 4 are H, R 2 may not be —OH; and that when one of X, Y and Y′ is N and R 3 and R 4 are H, R 2 may not be H; and that when R 2 is H, OH or NH 2 and R 3 and R 4 are H, R 1 may not be aryl-C 1-4 alkyl; and excluding compounds represented by Formula I″ or pharmaceutically acceptable salts thereof: wherein: R 1 , X, Y, m and n are as defined above R 2 is —H, —NH 2 , —NH-Q-V-T, wherein Q is —C(O)— or —SO 2 — and V and T are as defined above; unless X is N in which case R 2 is absent R 3 is H, halogen, C 1-4 alkyl, OC 1-4 alkyl, —NH 2 , NH—C 1-4 alkyl, or hydroxy; R 4 is H, halogen, C 1-4 alkyl, OC 1-4 alkyl, CO 2 H, —NH 2 , NH—C 1-4 alkyl, or hydroxy.