Patent ID: 8563597

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein X 1 is a bond or optionally substituted alkylene; X 2 is a bond, C(O), S(O), S(O) 2 , optionally substituted amino, or optionally substituted alkylene; R 1 and R 2 are in each instance independently selected from the group consisting of hydrogen, P(O)(OR) 2 , and a prodrug forming group, where R is independently selected in each instance from hydrogen or alkyl; R 3 is sulfonyl, acyl, amino, alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted; R 4 is hydrogen, halogen, —OH, or —NO 2 , or R 4 is amino, alkoxyl, sulfonyl, acyl, alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, and heteroaryl, each of which is optionally substituted; or R 3 , R 4 , X 2 and the attached nitrogen form an optionally substituted heterocyclyl; R 5 and R 6 are independently in each instance hydrogen or selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, each of which is optionally substituted; Z is wherein * indicates the point of attachment; m is 0, 1, or 2; W 1 and W 2 are in each instance independently selected from the group consisting of optionally substituted alkylene, alkyleneoxy, alkyleneamino, alkylenethio, alkylenesulfoxyl, and alkylenesulfonyl; W 3 and W 4 are in each instance independently selected from the group consisting of amino, oxygen, alkylene, alkyleneoxy, alkyleneamino, and heteroalkylene, wherein at least one of W 1 or W 2 is oxygen, and wherein when one of W 1 or W 2 is optionally substituted methylene, at least one of W 3 or W 4 is oxygen or alkyleneoxy, and wherein Z does not include a peroxide bond, a sulfenate bond, or a sulfenamide bond; X 3 is a bond or optionally substituted methylene; and Y is hydrogen, hydroxyl, or carbonyl, or amino, acyl, sulfonyl, alkyl, or heteroalkyl, each of which is optionally substituted is described; or Z is wherein * indicates the point of attachment; n is 1, 2, or 3; W 1 and W 2 are in each instance independently selected from the group consisting of optionally substituted methylene, oxygen, and amino; W 3 and W 4 are in each instance independently selected from the group consisting of amino, oxygen, alkylene, and heteroalkylene, wherein at least one of W 1 or W 2 is oxygen, and wherein when one of W 1 or W 2 is optionally substituted methylene, at least one of W 3 or W 4 is oxygen, and wherein Z does not include a peroxide bond, a sulfenate bond, or a sulfenamide bond; X 3 is a bond or optionally substituted methylene; and Y is hydrogen, hydroxyl, or carbonyl, or amino, acyl, sulfonyl, alkyl, or heteroalkyl, each of which is optionally substituted.