Patent ID: 7345095

Claim:
A method of treating Alzheimer's disease in a mammal, comprising administering to said mammal an amount of the compound of Formula I, wherein said compound of Formula I has the following structure: wherein R 1 and R 2 are each independently selected from —H, —C 1 -C 8 alkyl, —C 2 -C 8 alkenyl, —C 1 -C 8 alkoxy, —C 2 -C 8 alkenoxy, —C 1 -C 8 hydroxyalkyl, —C 2 -C 8 hydroxyalkenyl, -halo, —CN, —NO 2 , —(CH 2 ) q NC(═O)R 6 , —(CH 2 ) q C(═O)OR 5 , —(CH 2 ) q C(═O)NR 6 R 7 , —(CH 2 )q NR 6 R 7 , C 3 -C 8 cycloalkyl and —C 5 -C 8 cycloalkenyl, wherein R 1 and R 2 are each optionally independently substituted with from one to three substituents independently selected from —C 1 -C 6 alkoxy, —C 1 -C 6 alkyl -halo and —OH; R 3 is a group of the Formula II or the Formula III, each as depicted below wherein B is absent or is selected from C 1 -C 8 alkylene and C 2 -C 4 alkenylene; D is selected from —C 1 -C 8 alkyl, —C 3 -C 10 cycloalkyl, -(3-10 membered) heterocycloalkyl and -(5-7 membered) heteroaryl; X, Y and Z are each independently selected from —H, —C 1 -C 8 alkyl, —C 2 -C 8 alkenyl, —C 1 -C 8 alkoxy, —C 2 -C 8 alkenoxy, —C 1 -C 8 hydroxyalkyl, —C 2 -C 8 hydroxyalkenyl, -halo, —OH, —CN, —NO 2 , —(CH 2 ) q —NR 7 R 8 , —(CH 2 ) q —NHC(═O)R 9 , —(CH 2 ) q —C(═O)R 9 , —(CH 2 ) q —C(═O)NR 7 R 8 , —(CH 2 ) q —C(═O)OR 9 , —(CH 2 ) q —SO 2 R 9 , —S(C 1 -C 8 alkyl), —C 3 -C 8 cycloalkyl, —(CH 2 ) q -((3-10 membered) heterocycloalkyl), —(CH 2 ) q —(C 6 -C 14 aryl), —(CH 2 ) q -((4-10 membered) heteroaryl) and —(CH 2 ) q —(C 6 -C 14 aryloxy); wherein said X, Y and Z are each optionally independently substituted with from one to three substituents independently selected from —C 1 -C 8 alkyl, —C 2 -C 8 alkenyl, —C 1 -C 8 alkoxy, —C 2 -C 8 alkenoxy, C 1 -C 8 hydroxyalkyl, —C 2 -C 8 hydroxyalkenyl, halo, —OH and —CN; and wherein said alkoxy substituent of X, Y and Z is optionally independently substituted with from one to three substituents independently selected from halo; R 5 , R 6 R 7 , R 8 and R 9 are each independently selected from —H, —C 1 -C 12 alkyl, —C 2 -C 12 alkenyl, —C 3 -C 10 cycloalkyl, —C 5 -C 10 cycloalkenyl, —C 5 -C 13 bicycloalkyl, —C 7 -C 13 bicycloalkenyl, -(3-10 membered) heterocycloalkyl, —C 6 -C 14 aryl and -(5-8 membered) heteroaryl; wherein NR 6 R 7 or NR 7 R 8 may in each instance independently optionally form a -(3-8 membered) heterocycloalkyl; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; and q is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.