Patent ID: 7687541

Claim:
A compound of Formula I or Formula II or pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of (a) phenyl, optionally substituted at positions 3 and 4 halogens, (b) —O-isopropyl, (c) —O-cyclopropyl, and (d) —O—CH 2 -cyclopropyl; R 2 is selected from the group consisting of: (a) —S(O) 2 CH 3 , and (b) —S(O) 2 NH 2 ; R 3 is selected from the group consisting of (a) hydrogen, (b) methyl, (c) ethyl, (d) hydroxyl, (e) F, Cl, and (f) CF 3 ; R 4 is selected from the group consisting of (a) methyl, and (b) ethyl; X 1 is selected from the group consisting of: (a) —OCH 2 —, (b) —OC(R 3 )(R 4 )—, (c) —CH 2 -linker —O—, and (d) —C(R 3 )(R 4 )-linker-O—, wherein the oxygen end of X 1 is attached to the carbonyl carbon of Formula I; X 2 is selected from the group consisting of: (a) —OCH 2 —, (b) —OC(R 3 )(R 4 )—, (c) —CH 2 -linker-O—, and (d) —C(R 3 )(R 4 )-linker-O—; wherein the carbon end of X 2 is attached to the carbon adjacent to the R 2 -phenyl explicitly shown; -linker—is selected from the group consisting of (a) —C(O)—(CH2) m —O—, (b) —C(O)—(CH 2 ) m (—O—(CH 2 )n) p —O—, and (c) —C(O)-aryl-O—, wherein m, n and p are each independently integers ranging from 0 to 6; Y is selected from the group consisting of (a) hydrogen, and (b) acyl, wherein the acyl group is selected from the group consisting of (a) —C(O)—C 1-6 alkyl, optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of halo, hydroxyl, amino, C 1-3 alkoxy, aminoC 1-3 alkyl, (b) —C(O)-aryl, and (c) an amino acid; Z is selected from the group consisting of: (a) —OR 5 , (b) —NR 5 R 6 , wherein R 5 and R 6 are each independently selected from (a) hydrogen, (b) C 1-6 alkyl, (c) phenyl, and (d) C 1-2 -phenyl, wherein R 5 and R 6 choices (b), (c) and (d) are optionally substituted with 1, 2, or 3 substituents selected from halo, hydroxyl, amino, C 1-3 alkyl, and C 1-3 alkoxy; X is selected from the group consisting of: (a) —OCH 2 —, and (b) —C(R 3 )(R 4 )O—, wherein the carbon at the end of X is attached to the carbon adjacent to the phenyl; Y 1 is -linker1-, which is selected from the group consisting of (a) —C(O)—(CH 2 ) r —C(O)—, (b) —C(O)-aryl-C(O)—, (c) —C(O)—(CH 2 ) r —(O—(CH 2 ) s ) t —C(O)—, and (d) —C(O)—(CH 2 ) r —CH—(CH 2 ) s —C(O)—, wherein r, s and t are each independently integers ranging from 0 to 6; and Z 1 is selected from the group consisting of: (a) —OR 5 , and (b) —NR 5 R 6 .