Patent ID: 7223768

Claim:
A compound of the formula: in which A is six-membered substituted aryl; X is a member selected from CO and CS; W is N; Z is a member selected from the group consisting of —CH 2 —, —CHF—, —CF 2 —, and —NR 4 (CR 4a R 4b ) s — wherein R 4 is a member selected from H and a substituted or unsubstituted C 1 –C 5 alkyl group; R 4a and R 4b are members independently selected from H, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 3 –C 8 cycloalkyl, substituted or unsubstituted 5–7 membered heterocyclyl, and substituted or unsubstituted C 1 –C 8 alkyl; s is an integer from 1 to 3; Y is (CR 5 R 6 ) n , wherein n is an integer from 0–4; and R 5 and R 6 are members independently selected from H, F, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 3 –C 8 cycloalkyl, substituted or unsubstituted 5–7 membered heterocyclyl, and substituted or unsubstituted C 1 –C 8 alkyl; R 1 is a member selected from substituted or unsubstituted aryl, and R 2 is a member selected from the group consisting of CF 3 , substituted or unsubstituted C 1 –C 8 alkyl, substituted or unsubstituted aryl, such that when X is C(O); A is a substituted phenyl forming a 1,3-benzodioxolyl ring; W is N; and Y—R 2 is unsubstituted acyclic alkyl, acyclic alkyl substituted with an amide or unsubstituted phenyl, then Z—R 1 is other than acyclic alkyl substituted with unsubstituted phenyl, and acyclic alkyl substituted with 4-phenyl-1-halo.