Patent ID: 7589095

Claim:
A 4-phenyl-pyrimidine-2-carbonitrile compound having the general formula I wherein R represents 1-3 optional substituents independently selected from (C 1-6 )alkyl (optionally substituted with one or more halogens), (C 1-6 )alkyloxy (optionally substituted with one or more halogens), cyano, halogen, hydroxy, nitro, (C 3-6 )cycloalkyl, CO(C 1-6 )alkyl, S(C 1-6 )alkyl, SO(C 1-6 )alkyl, SO 2 (C 1-6 )alkyl, SO 2 NH(C 1-8 )alkyl, SO 2 NH 2 , NHCO(C 1-8 )alkyl and CO 2 H; or 2 substituents R on adjacent positions represent together OCH 2 O, OCH 2 CH 2 O or CH 2 CH 2 O; R 1 is H or (C 1-6 )alkyl; R 2 is (C 2-6 )alkyl, optionally substituted with OH, (C 1-4 )alkyloxy, (C 6-10 )aryloxy, (C 6-10 )aryl(C 1-4 )alkyloxy, one or more halogens, NR 3 R 4 , CO 2 H or CONR 6 R 7 ; R 3 and R 4 are independently H, (C 1-8 )alkyl [optionally substituted with one or more halogens, (C 1-4 )alkyloxy or (C 6-10 )aryloxy], (C 3-8 )cycloalkyl [optionally substituted with one or more halogens], (C 1-4 )alkyl substituted with a 4-8 membered saturated heterocyclic ring comprising a heteroatom selected from O, S and NR 5 , a 4-8 membered saturated heterocyclic ring comprising a heteroatom selected from O, S and NR 5 , (C 6-10 )aryl, (C 2-9 )heteroaryl [optionally substituted with 1-3 substituents selected from halogen, CF 3 , (C 1-4 )alkyl and (C 1-4 )alkyloxy], (C 6-10 )aryl(C 1-4 )alkyl or (C 2-9 )heteroaryl(C 1-4 )alkyl; or R 3 and R 4 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally substituted with one or more halogens or with CONR 8 R 9 , and optionally further comprising 1 or more heteroatoms selected from O, S and NR 5 ; or R 3 is H or (C 1-4 )alkyl; and R 4 is (C 1-4 )alkyl substituted with CONR 8 R 9 , COOR 10 , NR 8 , R 9 , NR 8 COR 9 , or NR 8 CONR 9 R 10 ; R 5 is H, (C 1-4 )alkyl [optionally substituted with (C 3-8 )cycloalkyl, (C 6-10 )aryl or (C 2-5 )heteroaryl], (C 3-8 )cycloalkyl, (C 6-10 )aryl or (C 2-5 )heteroaryl; R 6 and R 7 are independently H, (C 1-4 )alkyl or a 4-8 membered saturated heterocyclic ring comprising a heteroatom selected from O, S and NR 5 ; or R 6 and R 7 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally substituted with one or more halogens, and optionally further comprising 1 or more heteroatoms selected from O, S and NR 5 ; R 8 and R 9 are independently H or (C 1-4 )alkyl; or R 8 and R 9 together with the atoms to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally comprising 1 or more heteroatoms selected from O, S and NR 5 : R 10 is H or (C 1-4 )alkyl; or a pharmaceutically acceptable salt thereof.