Patent ID: 7413854

Claim:
A method for synthesizing a templated molecule, comprising the steps of: a) providing at least one template comprising of one or more codons, b) providing a first functional entity attached to a first zipping oligonucleotide capable of reversible interaction with a second zipping oligonucleotide, c) providing one or more building blocks, each building block comprising a further functional entity linked to an anti-codon by a linker, wherein the anti-codon complements a codon of the template, wherein the further functional entity is connected to the second zipping oligonucleoticle capable of reversible interaction with the first zipping oligonucleotide attached to the first functional entity provided in step b), and wherein the further functional entity is capable of being chemically connected to the first functional entity provided in step b), d) contacting the components provided in steps a), b) and c) with each other under conditions allowing for i) specific hybridization of building block anti-codon(s) to the codon(s) of the template(s) and ii) dimerization of two zipping oligonucleotides attached to different functional entities, e) allowing a further functional entity of the one or more building blocks provided in step c) to form a chemical connection to the first functional entity provided in step b), and f) obtaining a templated molecule attached to the template which directed the synthesis thereof.