Patent ID: 7807670

Claim:
A compound of formula (I″) or formula (I′″) or an enantiomer or diastereoisomer thereof: wherein: X is H and W is OH; or X and W together form a carbonyl group or an epoxide group; R 1 is H; or one or two substituents independently selected from the group consisting of: hydroxy; halo; lower alkyl; lower alkoxy; lower thioalkyl; haloalkyl; or —C(O)R 2 wherein R 2 is lower alkyl, aryloxy or benzyloxy; Y is phenyl optionally mono- or di-substituted with R 5 or C(O)R 6 , wherein R 5 is lower alkyl, lower cycloalkyl, lower alkoxy, halo, hydroxy, nitrile or trifluoromethyl, and R 6 is lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy or trifluoromethyl; said phenyl ring being optionally fused with a saturated or unsaturated 4 to 6-membered carbocyclic ring; or Y is ethylene-phenyl, said ethylene moiety being optionally mono-substituted with lower alkyl wherein said phenyl ring is optionally mono- or di-substituted with R 5 or C(O)R 6 , wherein R 5 and R 6 are as defined above; said phenyl ring being optionally fused with a saturated or unsaturated 4 to 6-membered carbocyclic ring; R 3 is selected from the group consisting of: lower alkyl, lower cycloalkyl, aryl or lower aralkyl, all of which are optionally mono- or di-substituted with: lower alkyl, lower cycloalkyl, haloalkyl, halo, CN, azido, lower alkoxy, (lower alkyl)acyl, C 1-6 thioalkyl, C 1-6 alkylsulfonyl, NHC(O)-lower alkyl, NHC(O)-aryl, NHC(O)—O-lower alkyl or, NHC(O)O-aryl; aryl or aryloxy, hydroxy, nitro, amino or Het, said Het being optionally mono- or di-substituted with lower alkyl lower cycloalkyl, lower alkoxy, halo, hydroxy, nitrile trifluoromethyl, or C(O)R 6 wherein R 6 is as defined above; provided that when R 3 is aryl mono- or disubstituted with Het, Het is not optionally substituted morpholine or an optionally substituted five-membered, unsaturated heterocycle containing from one to three heteroatoms selected from nitrogen, oxygen and sulfur; said lower cycloalkyl, aryl, lower aralkyl or Het being optionally fused with a saturated or unsaturated 4 to 6-membered ring optionally containing a heteroatom selected from N, 0 and S; and R 4 is a carboxylic acid, a salt or an ester thereof.