Patent ID: 6878813

Claim:
An elastase-resistant antithrombin III (ATIII) comprising at least two modifications, wherein the modifications occur at positions P4 and P5 of the ATIII, wherein P4 and P5 are the fourth and fifth amino acids towards the amino terminal side of the scissile bond of the reactive center respectively, wherein P4 comprises an amino acid selected from the group consisting of alanine; phenylalanine; glycine; and proline, and wherein P5 comprises an amino acid selected from the group consisting of glutamic acid; phenylalanine; glycine; and proline wherein the elastase-resistant ATIII has greater resistance to human neutrophil elastase as compared to plasma ATIII wherein the ATIII retains a thrombin inhibitory activity defined by a k app of at least about 0.2M −1 sec −1 ×10 3 .