Patent ID: 8426426

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Q is —CH 2 —, —NH— or —O—; W is C—R 4 ; X is selected from CH or CF; R 1 is a 5-6 membered aryl ring having 1-3 heteroatoms independently selected from oxygen, nitrogen, or sulfur, wherein: R 1 is substituted with 0-3 groups independently selected from R, oxo, CO 2 R′, OR′, N(R′) 2 , SR′, NO 2 , halogen, CN, C(O)N(R′) 2 , NR′C(O)R′, SO 2 R′, SO 2 N(R) 2 , or NR′SO 2 R′; each R′ is independently selected from hydrogen, C 1-4 aliphatic, or a 5-6 membered saturated, unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: R′ is substituted with 0-3 groups independently selected from halogen, oxo, R o , N(R o ) 2 , OR o , CO 2 R o , NR o C(O)R o , C(O)N(R o ) 2 , SO 2 R o , SO 2 N(R o ) 2 , or NR o SO 2 R o ; each R o is independently selected from hydrogen or C 1-4 aliphatic; R 2 is selected from hydrogen or C 1-3 aliphatic group; R 3 is selected from C(O)NHR, C(O)N(R) 2 , CH(O), C(O)R, C(O)C(O)N(R 2 )R, SO 2 R, SO 2 N(R) 2 , SO 2 NHR, C(R′)═NOR, C(R′)═NOH, C(R′)═NR, C(R′)═N—N(R 2 )R, NO, or NO 2 ; each R is independently selected from T-Ar or a C 1-6 aliphatic group, wherein: said C 1-6 aliphatic group is substituted with 0-3 groups independently selected from R′, oxo, CO 2 R′, OR′, N(R′) 2 , SR′, NO 2 , halogen, CN, C(O)N(R′) 2 , NR′C(O)R′, SO 2 R′, SO 2 N(R′) 2 , or NR′SO 2 R′; T is (CH 2 ) y , wherein y is 0, 1, or 2; Ar is selected from: (a) a 3-8 membered saturated, unsaturated, or aryl ring; (b) a 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (c) a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: Ar is substituted with 0-3 groups independently selected from R′, oxo, CO 2 R′, OR′, N(R′) 2 , SR′, NO 2 , halogen, CN, C(O)N(R′) 2 , NR′C(O)R′, SO 2 R′, SO 2 N(R′) 2 , or NR′SO 2 R′; and R 4 is selected from hydrogen, fluorine, or OCH 3 .