Patent ID: 8350083

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein L 1 is a bond; Y 1 is —N(R b )—; Y 2 is ═O, ═S or ═N—CN; Y 3 is —N(R c )—; Ar 1 is 1,2,3,4-tetrahydro-quinolin-2-yl, 1,2,3,4-tetrahydro-quinolin-3-yl, or 1 ,2,3,4-tetrahydro-quinolin-4-yl; wherein each Ar 1 is optionally substituted with 1, 2, 3, 4, or 5 substituents as represented by R w , two R w that are attached to the same carbon atom of the monocyclic heterocycle, together with the carbon atom to which they are attached, optionally form a monocyclic cycloalkyl ring wherein said monocyclic cycloalkyl ring is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of oxo, alkyl, and haloalkyl; R 1 is hydrogen, hydroxy or alkoxy; R w , R 2 , R 3 , R 4 , and R 5 , are each independently hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, nitro, R e OS(O) 2 —, R f R g N—, (R f R g N)alkyl, (R j R k N)carbonyl, (R j R k N)carbonylalkyl or (R j R k N)sulfonyl; R b and R c are each independently hydrogen or alkyl; R e is alkyl, haloalkyl, aryl, or arylalkyl; R f and R g , at each occurrence, are each independently hydrogen, alkenyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, arylalkyl, arylcarbonyl, carboxyalkyl, cycloalkylalkyl, haloalkyl, heteroarylalkyl, or heteroarylcarbonyl; or R f and R g taken together with the nitrogen atom to which they are attached form a heterocyclic ring; and R j and R k , at each occurrence, are each independently hydrogen, alkenyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, alkylcarbonylalkyl, carboxyalkyl, cycloalkylalkyl, haloalkyl, or hydroxyalkyl.