Patent ID: 7569568

Claim:
A compound of the formula (I) wherein: Ar 1 is carbocycle optionally substituted with one R 1 , and wherein Ar 1 is independently substituted with two R 2 groups; R 1 is hydrogen, NO 2 , —N(R c ) 2 , J-C(O)—N(R c )— or J-S(O) m —N(R c )— m is 0, 1 or 2 and wherein R c is chosen from hydrogen or C1-5 alkyl; J is chosen from C1-10 alkyl and carbocycle each optionally substituted by R b ; R 2 is chosen from C1-6 alkyl or C3-7 cycloalkyl which may optionally be partially or fully halogenated, C1-4 acyl, aroyl, C1-4 alkoxy, which may optionally be partially or fully halogenated, halogen, C1-6 alkoxycarbonyl, carbocyclesulfonyl and —SO 2 —CF 3 ; R 3 , R 4 , R 6 , R 7 and R 8 are each independently chosen from hydrogen, halogen, C1-5 alkyl, C1-5 alkoxy, C1-5 alkyl C1-5 alkoxy, hydroxy, hydroxy C1-5 alkyl or amino optionally mono- or disubstituted by C1-5 alkyl, aryl or aryl C1-5 alkyl; R 5 is chosen from a bond, —O—, —S—, —N<, —NH—, C(O), a linear chain chosen from —NH(CR 7 R 8 ) n —, —(CR 7 R 8 ) n —, —O(CR 7 R 8 ) n —, —C(O)—O(CR 7 R 8 ) n —, —S(CR 7 R 8 ) n —, C(O)(CR 7 R 8 ) n — and —C(O)NH(CR 7 R 8 ) n —, wherein n is 1-5 and each of the aforementioned R 5 is further substituted by R a , R a and R b are each independently chosen from pyridinyl, piperidinyl and morpholinyl each of the aforementioned are optionally partially or fully halogenated, and each X is independently O or S or the pharmaceutically acceptable salt, acid, ester, entiomers, diastereomers, or diasteromeric mixture thereof.