Patent ID: 8133996

Claim:
A process for preparing anagrelide of Formula (II): which comprises: (i) alkylating a compound of Formula (V): where R is a leaving group other than hydrogen with glycine ethyl ester in a suitable solvent, using a base, to produce a compound of Formula (I′): (ii) converting the compound of Formula (I′) to the hydrochloride salt in a suitable solvent, to obtain compound of Formula (I): (iii) reducing the nitro group of Formula (I) with a suitable reducing agent to convert it to an amine of Formula (VI): (iv) reacting the compound of Formula (VI) with a cyanogen halide to form compound of Formula (VII): wherein halide is chloro, bromo or iodo; and (v) cyclising compound of Formula (VII), to form compound of Formula (II).