Patent ID: 7939670

Claim:
A compound of the formula (I): wherein D is a 6 membered aromatic group; A, B and Q are independently hydrogen, C 1-10 alkyl, C 3-12 cycloalkyl, C 1-10 alkoxy, C 3-12 cycloalkoxy, —CH 2 OH, —NHSO 2 , hydroxyC 1-10 alkyl-, aminocarbonyl, C 1-4 alkylaminocarbonyl-, diC 1-4 alkylaminocarbonyl, acylamino-, acylaminoalkyl-, amide, sulfonylaminoC 1-10 alkyl-, or A-B can together form a C 2-6 bridge, or B-Q can together form a C 3-7 bridge, or A-Q can together form a C 1-5 bridge; Z is selected from the group consisting of a bond, straight or branched C 1-6 alkylene,—NH—, —CH 2 O—, —CH 2 NH—, —CH 2 N(CH 3 )—, —NHCH 2 —, —CH2CONH—, —NHCH 2 CO—, —CH 2 CO—, ——CH 2 COCH 2 —, —CH(CH 3 )—, —CH═, —O— and-HC═CH—, wherein the carbon and/or nitrogen atoms are unsubstituted or substituted with one or more lower alkyl, hydroxy, halo or alkoxy group; R 1 is selected from the group consisting of hydrogen, C 3-12 cycloalkyl, C 2-10 alkenyl, amino, C 1-10 alkylamino-, C 3-12 cycloalkylamino-, —C 1-4 COOV 1 , cyano, cyanoC 1-10 alkyl-, cyanoC 3-10 cycloalkyl-, NH 2 SO 2 —, NH 2 SO 2 C 1-4 alkyl-, NH 2 SOC 1-4 alkyl-, aminocarbonyl-, C 1-4 alkylaminocarbonyl-, diC 1-4 alkylaminocarbonyl-, benzyl, C 3-12 cycloalkenyl-, a monocyclic, bicyclic or tricyclic aryl or heteroaryl ring, and a spiro ring system of the formula (V): wherein X 1 and X 2 are independently selected from the group consisting of NH, O, S and CH 2 ; and wherein said alkyl, cycloalkyl, alkenyl, C 1-10 alkylamino-, C 3-12 cycloalkylamino-, or benzyl of R 1 is optionally substituted with 1-3 substituents selected from the group consisting of halogen, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, nitro, trifluoromethyl-, cyano, —COOV 1 , —C 1-4 COOV 1 , cyanoC 1-10 alkyl-, —C 1-5 (═O)W 1 , —C 1-5 NHS(═O) 2 W 1 , —C 1-5 NHS(═O)W 1 , a 5-membered heteroaromaticC 0-4 alkyl-, phenyl, benzyl, benzyloxy, said phenyl, benzyl, and benzyloxy optionally being substituted with 1-3 substituents selected from the group consisting of halogen, C 1-10 alkyl-, C 1-10 alkoxy-, and cyano; and wherein said C 3-12 cycloalkyl, C 3-12 cycloalkenyl, monocyclic, bicyclic or tricyclic aryl, heteroaryl ring, or spiro ring system of the formula (V) is optionally substituted with 1-3 substituents selected from the group consisting of halogen, C 1-10 alkyl, C 1-10 alkoxy, nitro, trifluoromethyl-, phenyl, benzyl, phenyloxy and benzyloxy, wherein said phenyl, benzyl, phenyloxy or benzyloxy is optionally substituted with 1-3 substituents selected from the group consisting of halogen, C 1-10 alkyl, C 1-10 alkoxy, and cyano; W 1 is hydrogen, C 1-10 alkyl, C 3-12 cycloalkyl, C 1-10 alkoxy, C 3-12 cycloalkoxy, —CH 2 OH, amino, C 1-4 alkylamino-, diC 1-4 alkylamino, or a 5-membered heteroaromatic ring optionally substituted with 1-3 lower alkyl; V 1 is H, C 1-6 alkyl, C 3-6 cycloalkyl, benzyl or phenyl; or a pharmaceutically acceptable salt thereof.