Patent ID: 8592149

Claim:
A method for generating a reference index which correlates treatment response to nine FcγRIIIa and FcγRIIa genotype groups, said method comprising: (a) genotyping multiple human subjects, each subject has or had an ADCC-treatable disease or disorder, and is or was administered antibody therapy for said disease or disorder resulting in a treatment response; said genotyping classifies said subject into one of nine genotype groups corresponding to V/V 158 and H/H 131 , designated group I; V/F 158 and H/H 131 , designated group II; F/F 158 and H/H 131 , designated group III; V/V 158 and H/R 131 , designated group IV; V/F 158 and H/R 131 , designated group V; F/F 158 and H/R 131 , designated group VI; V/V 158 and R/R 131 , designated group VII; V/F 158 and R/R 131 , designated group VIII; and F/F 158 and R/R 131 , designated group IX; and (b) further classifying said treatment response of each subject based on its FcγRIIIa V/F 158 and FcγRIIa H/R 131 genotype groups to generate a reference index which correlates said nine categories of treatment response with said nine genotype groups.