Patent ID: 7776898

Claim:
A method to treat pain comprising administering to a mammal in need of such treatment, an effective amount of a compound of formula (I): wherein: R 1 is aryl, Het, (C 1-7 )alkyl, or (C 3-12 )cycloalkyl, which (C 1-7 )alkyl or (C 3-12 )cycloalkyl are each independently optionally substituted with from 1 to 5 aryl, Het, OR a , halo, NO 2 , NR a R b , cyano, CONR a R b , CO 2 R a , SO m R a , S(O) m NR a R b , or P(═O)(OR a )(R a ); R 2 is H, (C 1-7 )alkyl, (C 3-12 )cycloalkyl, aryl, Het, or a group that includes one or more basic atoms; R 3 is H, or (C 1-7 )alkyl; each R 4 is independently OR a , trifluoromethoxy, trifluoromethyl, halo, NO 2 , NR a R b , cyano, CONR a R b , CO 2 R a , SO m R a , S(O) m NR a R b , P(═O)(OR a )(R a ), (C 1-7 )alkyl, (C 2-7 )alkanoyl, (C 2-7 )alkanoyloxy, or (C 3-12 )cycloalkyl; R a and R b are each independently H, (C 1-7 )alkyl, (C 3-12 )cycloalkyl, (C 2-7 )alkanoyl, (C 2-7 )alkanoyloxy, or aryl, or R a and R b together with a nitrogen to which they are attached form a Het; wherein any aryl or Het of R 1 or R 2 is optionally substituted with from 1 to 4 substituents independently selected from OR a , trifluoromethoxy, trifluoromethyl, halo, NO 2 , NR a R b , cyano, CONR a R b , CO 2 R a , SO m R a , S(O) m NR a R b , P(═O)(OR a )(R a ), (C 1-7 )alkyl, (C 2-7 )alkanoyl, (C 2-7 )alkanoyloxy, or (C 3-12 )cycloalkyl; and m is 0, 1, or 2; n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.