Patent ID: 8232271

Claim:
A compound according to formula I wherein: R 1 is (alkylene) 0-6 COX, (alkylene) 0-6 NR a R b , (alkylene) 0-6 CN, C 1-6 hydroxyalkyl, or C 1-3 alkylsulfonyl-(alkylene) 0-3 ; X is hydrogen, hydroxy, C 1-6 alkoxy or NR c R d ; R 2 is hydrogen, C 1-6 alkoxy, C 1-3 alkyl or halogen; R a is (a) hydrogen, (b) C 1-6 alkyl, (c) C 1-6 acyl, (d) aroyl, (e) —SO 2 —C 1-6 alkyl, (f) —SO 2 -aryl, (g) —SO 2 —C 1-3 arylalkyl, (h) aryl-C 1-3 alkyl, or (i) SO 2 NR e R f wherein R e and R f are independently hydrogen or C 1-3 alkyl, (j) pyridinoyl, (k) C 3-7 cycloalkyl-carbonyl or (l) CONHR e R f , (m) —SO 2 —C 3-6 cycloalkyl or (n) 4-methanesulfonylamino-pyrrolidine-2-carbonyl wherein said cycloalkane moiety is substituted by C 1-3 alkylsulfonylamino and wherein said aryl, said aroyl and said pyridinoyl are each independently optionally substituted with one to three groups independently selected from hydroxy, C 1-6 alkoxy, C 1-6 alkoxy, amino, C 1-3 alkylamino, C 1-3 dialkylamino, C 1-6 acylamino, C 1-6 alkylsulfonylamino, bis-(C 1-6 alkylsulfonyl)amino, C 1-6 alkyl and halogen; R b is hydrogen C 1-6 alkyl, optionally substituted aryl, C 1-6 hydroxyalkyl, C 1-3 acyloxy-C 1-6 alkyl, heterocyclyl-C 1-3 alkyl; C 3-6 cycloalkyl-C 1-3 alkyl, pyrrolidin-3-ylmethyl, 1-acetyl-pyrrolidin-3-ylmethyl, piperidin-4-yl, or pyridinyl; or, R a and R b together are C(═O)C(Me) 2 NHC(═O), (CH 2 ) 3-5 S(═O) 2 , (CH 2 ) 2-5 C(═O), C(═O)CH 2 C(Me) 2 CH 2 C(═O), HC═CC(Br)═CHC(═O), C(═O)(CH 2 ) 2-4 C(═O), HC═CC(═O)CEt 2 (═O) or S(═O) 2 NR 6 (CH 2 ) 3-5 wherein R 6 is hydrogen, C 1-6 alkyl or Boc; or, R a and R b together with the nitrogen to which they are attached are (a) phthaloyl (b) 1-methyl-1,3-dihydro-2-oxo-benzoimidazol-3-yl, (c) 5-oxo-pyrrolidin-1-yl optionally substituted by C 1-6 carboalkoxy, carboxyl or C 1-3 hydroxymethyl, (d) 3-hydroxymethyl-pyrrolidin-1-yl, (e) 2-oxo-oxazolidin-3-yl optionally substituted with C 1-6 alkyl or (f) 3-oxo-2,3-dihydro-1H-isoindolyl optionally substituted with C 1-6 alkylsulfonylamino or C 3-6 cycloalkylsulfonylamino; R c is hydrogen, C 1-6 alkyl; R d is hydrogen, C 1-6 alkyl; pyridinyl-C 1-3 alkyl, cyano-C 1-3 alkyl, 4-C 1-3 alkoxy-C 1-6 alkyl or aryl-C 1-3 alkyl optionally substituted with halogen; or, R c and R d together are (CH 2 ) 2 X 1 (CH 2 ) 2 wherein X 1 is O, SO 2 or NR 7 wherein R 7 is hydrogen, C 1-6 alkyl, C 1-3 alkoxy-C 1-3 alkyl or C 1-3 acyl, or, R c and R d together with the nitrogen to which they are attached are 4,4-difluoro-piperidin-1-yl, 4-phenoxy-piperidin-1-yl, 3-hydroxy-azetidine, 4-cyano-piperidin-1-yl, 3-(hydroxylmethyl)pyrrolidin-1-yl or 2-hydroxymethyl-morpholin-4-yl; R 3a , R 3b and R 3c (i) when taken independently are selected independently from C 1-3 alkyl, C 1-2 alkoxy or C 1-2 fluoroalkyl or (ii) when taken together, R 3a and R 3b together are C 2-4 methylene and R 3c is C 1-3 alkyl; R 4 is hydrogen, C 1-6 alkyl; R 5 is hydrogen, halogen or C 1-3 alkyl; p is zero to three; or, a pharmaceutically acceptable salt thereof.