Patent ID: 7595318

Claim:
A conjugate of formula I: or a pharmaceutically acceptable salt thereof, wherein R is a POAM moiety or R a , where R a is selected from the group consisting of amino, hydroxyl, alkoxy, substituted alkoxy, substituted amino, alkyl, substituted alkyl, -alkyl-O-alkyl, substituted -alkyl-O-alkyl, wherein each R a is optionally substituted with a POAM moiety covalently bonded to R a optionally by a linker; Ar 1 is selected from the group consisting of heteroaryl and substituted heteroaryl, wherein each Ar 1 is optionally substituted with a POAM moiety covalently bonded to Ar 1 optionally by a linker; Ar 2 is phenyl or substituted phenyl, where each phenyl group is optionally further substituted with a POAM moiety covalently bonded to Ar 2 optionally by a linker; W is —(CH 2 )—; X is selected from the group consisting of —S—, —SO—, —SO 2 and optionally substituted —OH 2 —; Y is selected from the group consisting of —O—, —S— and —NR 1 — wherein R 1 is selected from the group consisting of hydrogen and C 1 -C 5 alkyl; V is —NR 2 R 3 where R 2 and R 3 together with the nitrogen to which they are attached represent a heterocyclic ring or a substituted heterocyclic ring, and wherein V is optionally substituted with a POAM moiety covalently bonded to the heterocyclic ring, or substituted heterocyclic ring optionally by a linker; and n is 0, 1 or 2; provided that at least one of R, Ar 1 , Ar 2 , and V contains a POAM moiety; further provided that when R is a POAM moiety, n is one and X is not —S—, —SO—, or —SO 2 —; and still further provided that the conjugate of formula I has a molecular weight of no more than 100,000.