Patent ID: 8710020

Claim:
A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefit in the treatment of cancer comprising administering from 480 mg to 640 mg anti-clusterin antisense oligonucleotide intravenously to a human in need of treatment for a cancer expressing clusterin, which human also receives hormone ablation therapy, radiation therapy or a chemotherapeutic agent, wherein the nucleotide sequence of the anti-clusterin antisense oligonucleotide is CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti-clusterin antisense oligonucleotide has a phosphorothioate backbone throughout, has sugar moieties of nucleotides 1-4 and 18-21 bearing 2′-O-methoxyethyl modifications, has nucleotides 5-17 which are 2′ deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19.