Patent ID: 7566784

Claim:
A compound having formula I: or an enantiomer, diastereomer, pharmaceutically acceptable salt, thereof, wherein: R 1 is selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, and substituted aryl; V is CH 2 or NR 8 ; W and X are each CH; Y is O, S, or NR 9 ; Z is —CR 10 R 11 — or —(CR 10 R 11 ) m NR 12 —; m is 0 to 2; A is: wherein G is CR 14 or N; R 3 , R 8 and R 12 are independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, and/or substituted aryl; R 9 is H, alkyl, substituted alkyl, CN, NO 2 or SO 2 Amino; R 10 and R 11 are independently H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, and/or substituted aryl, or taken together to form a carbocyclic ring having from 3 to 8 atoms; R 13 , R 15 , R 16 , R 17 , are independently H, halogen, NR 27 R 28 , OR 29 , CO 2 R 30 , CO 2 NR 31 R 32 , SO 2 R 33 , alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, aryl, and/or substituted aryl; R 14 is H, halogen, NR 27 R 28 , COR 30 , CONR 31 R 32 , SO 2 R 33 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, and/or substituted aryl; and R 27 , R 28 , R 29 , R 30 , R 31 , R 32 and R 33 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, and/or substituted aryl; wherein: each of said substituted alkyl, each of said substituted alkenyl, and each of said substituted alkynyl are substituted with one or more substituents independently selected from the group consisting of alkyl, cycloalkyl, aryl, halogen, haloalkyl, alkoxy, alkylthio, hydroxy, —COOH, alkyloxycarbonyl, alkylcarbonyloxy, —NH 2 , and thiol; each of said substituted cycloalkyl is substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, —NH 2 , nitro, cyano, thiol, and alkylthio; and each of said substituted aryl is substituted with one or more substituents independently selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, —COOH, alkyloxycarbonyl, nitro, trifluoromethyl, —NH 2 , cyano, and thiol.