Patent ID: 8278343

Claim:
A compound of formula (I): wherein: R 1 is a phenyl group optionally substituted by one or two substituents independently selected from F, Cl, Br, CN, C 1-4 alkyl, C 1-4 alkylthio and C 1-4 alkoxy, fluoro-C 1-6 alkyl and fluoro-C 1-6 alkoxy, or a C 3-6 cycloalkyl group; X represents a direct link, NH, or O; Z is selected from R 2 is H or C 1-6 alkyl (optionally substituted with 1 to 3 fluorine atoms); R 3 is C 1-6 alkyl (optionally substituted with 1 to 3 fluorine atoms); Ar is an aromatic group consisting of 1, 2 or 3 aromatic rings, which aromatic rings are independently selected from phenyl and a 5- or 6-membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, and which aromatic rings, if there are 2 or more, can be fused or linked by one or more covalent bond, and which aromatic rings are optionally substituted by 1, 2 or 3 substitutents independently selected from F, Cl, CN, OH, C 1-6 alkyl, C 1-6 alkylthio, fluoro-C 1-6 alkyl, fluoro-C 1-6 alkylthio, fluoro-C 1-6 alkoxy, C 1-6 alkoxy, SO 2 R 4 , NR 5 R 6 , NHSO 2 R 7 , SO 2 NR 8 R 9 , and NHCOR 12 ; R 4 and R 7 are each independently C 1-6 alkyl (optionally substituted by 1 to 3 fluorine atoms); R 5 , R 6 , R 8 , R 9 , R 10 , R 11 and R 12 are each independently H or C 1-6 alkyl (optionally substituted by 1 to 3 fluorine atoms); or a pharmaceutically acceptable salt thereof.