Patent ID: 7235569

Claim:
The compound of formula I: or an N-oxide, stereoisomer or pharmaceutically acceptable salt thereof; wherein: A is a heterocycle having the formula: X is O; R 1 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, fluoro, alkoxy, cycloalkoxy, hydroxy, nitrile, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, fluorinated alkyl, aryl, aryloxy, alkylaryl, NH 2 , NHR 11 , NR 11 R 11 , —O-alkyl-NR 11 R 11 , or -aryl-O-alkyl-NR 11 R 11 ; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are, independently, hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, halo, cyano, alkoxy, cycloalkoxy, hydroxy, nitro, nitrile, NH 2 , NHR 11 , NR 11 R 11 , CHO, alkylcarbonyl, arylcarbonyl, carboxy, alkoxycarbonyl, alkoxycarbonylalkyl, alkylcarbonyloxy aminocarbonyl, alkylaminocarbonyl, fluorinated alkyl, aryl, aryloxy, alkylaryl, —O-alkyl-NR 11 R 11 , or -aryl-O-alkyl-NR 11 R 11 ; R 10 is hydrogen, alkyl, cycloalkyl, alkenyl of 3 to 6 carbon atoms (with the proviso that the carbon bearing the double bond should not be directly connected to N), alkynyl of 3 to 6 carbon atoms (with the proviso that the carbon bearing the triple bond should not be directly connected to N), alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, fluorinated alkyl, aryl, alkylaryl, SO 2 -aryl, or SO 2 -alkyl; R 2 and R 3 , R 3 and R 4 , or R 4 and R 5 can be attached together to form a cycloalkyl; R 11 is hydrogen, optionally substituted with R 2 , alkenyl, optionally substituted with R 2 (with the proviso that the carbon bearing the double bond is not bonded directly to the heteroatoms such as O, S or N—R 11 ), alkynyl optionally substituted R 2 (with the proviso that the carbon bearing the triple bond is not bonded directly to the heteroatoms such as O, S or N—R 11 ), aryl optionally substituted with R 2 , alkylaryl optionally substituted with R 2 , SO 2 -aryl, or SO 2 -alkyl; with the proviso that if two R 11 groups are attached to nitrogen, then they can together form a 4 to 7 membered cyclic system having 0 to 2 hetero atoms selected from O, S═(O) r , r is an integer from 0 to 2, and NR 11 ; and n is an integer from 1 to 6.