Patent ID: 8017105

Claim:
A composition of matter having the following formula: IEM-L-BHEM-PPBM, or a pharmaceutically acceptable salt thereof, wherein PPBM is a plasma protein binding moiety, wherein the plasma protein is human serum albumin (HSA); wherein the PPBM has 7-18 carbon atoms and comprises at least 1 aryl ring selected from phenyl, napthyl, biphenyl, and benzyl; wherein IEM is an image enhancing moiety and is selected from the following group: wherein one of R 1 -R 11 is L-BHEM-PPBM and the R 1 -R 11 groups that are not L-BHEM-PPBM are hydrogen; wherein R 12 , R 13 , and R 14 can be the same or different and are selected from the group consisting of O − and NH 2 ; wherein R 15 is H, CH 2 CH(OH)CH 3 , hydroxyl alkyl, or CH 2 COR 12 ; wherein said M is a paramagnetic metal ion chelated by the IEM and selected from the group consisting of Gd(III), Fe(III), Mn(II), Mn(III), Cr(III), Cu(II), Dy(III), Tb(III), Ho(III), Er(III), and Eu(III); wherein L is a linker connecting the IEM to the BHEM consisting of 1 to 4 —CH 2 — groups; and wherein the BHEM moiety is a blood half-life extending moiety and is a phosphodiester.