Patent ID: 7985554

Claim:
An isolated polypeptide comprising an amino acid sequence selected from (i) amino acids 529-562 of rat SV2C (SEQ ID NO:6), (ii) amino acids 529-562 of human SV2C (SEQ ID NO:18), (iii) amino acids 486 to 519 of rat SV2B (SEQ ID NO:4), (iv) amino acids 486 to 519 of mouse SV2B (SEQ ID NO:10), (v) amino acids 486 to 519 of human SV2B (SEQ ID NO:16), (vi) amino acids 543 to 576 of rat SV2A (SEQ ID NO:2), (vii) amino acids 454-546 of rat SV2C (SEQ ID NO:6), (viii) amino acids 454-546 of human SV2C (SEQ ID NO:18), (ix) amino acids 411 to 503 of rat SV2B (SEQ ID NO:4), (x) amino acids 411 to 503 of human SV2B (SEQ ID NO:16), (xi) amino acids 468 to 560 of rat SV2A (SEQ ID NO:2), (xii) amino acids 468 to 560 of human SV2A (SEQ ID NO:14), and (xiii) an amino acid sequence that is at least 95% identical to (iii), (iv), (v), (ix), or (x) and is capable of binding to botulinum neurotoxin A (BoNT/A), with the proviso that a polypeptide comprising a full length SV2 protein, a polypeptide consisting of an SV2 luminal domain, and a polypeptide comprising an SV2 luminal domain wherein the domain is flanked at one or both ends by a non-native flanking amino acid sequence are excluded.