Patent ID: 7119073

Claim:
A compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof: wherein Q is: wherein X is —CH 2 — or —O—; Y is a group of formula —C(R a ) 2 — where each R a is independently selected from hydrogen, hydroxyl, carboxylic acid, lower alkyl, aryl, heteroaryl, aralkyl and heteroalkyl, or the two R a groups together form a cycloalkyl group containing 3 to 7 carbon atoms; Z is a substituted or unsubstituted aryl or heteroaryl group; R 2 is a lower alkyl group, optionally substituted with one or more fluorine atoms, or is —CH 2 SH; R d is hydrogen, lower alkyl, lower alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxyl, alkoxy, aryloxy, heteroaryloxy, aralkoxy, heteroaralkoxy, thioether, sulfonyl or sulfoxide; R 4 is an alkyl, alkenyl, aralkyl, heteroaralkyl, aryl or heteroaryl group containing from 2 to 16 carbon atoms or is an acidic group; R 5 selected from (R 6 ) 2 NCO—, R 7 CO—, R 7 OCO—, R 7 NHCO—, R 7 CO.CO—, R 7 S(O) 2 — and R 8 pep; each R 6 , independently, is selected from hydrogen and optionally substituted, optionally interrupted lower alkyl or lower alkenyl, aryl, heteroaryl, aralkyl or heteroaralkyl groups, or the two R 6 taken together form a four to seven membered ring optionally containing one or more other heteroatoms in addition to the nitrogen atoms to which the R 6 groups are bonded; R 7 is an optionally substituted, optionally interrupted alkyl, alkenyl, aralkyl, heteroaralkyl, aryl or heteroaryl group containing from 1–18 carbon atoms; R 8 is a group of formula (R 6 ) 2 NCO—, R 7 CO—, R 7 OCO—, R 7 NHCO—, R 7 COCO—, or R 7 S(O) 2 —; “pep” if present is an amino acid, di, or tri peptide of formula C-B-A; wherein A is selected from naturally and non-naturally occurring amino acids having a hydrophobic side chain containing 1–20 carbon atoms; B is optionally absent, in which case C will also be absent, but if present is selected from naturally and non-naturally occurring amino acids having a side chain which includes an acidic functionality; C is optionally absent, either by itself or together with B, but if present is selected from naturally and non-naturally occurring amino acids containing an acidic functionality; R 17 is hydrogen, a lower alkyl, lower alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxyl, alkoxy, aryloxy, aralkoxy, heteroaralkoxy, thioether, sulfonyl or sulfoxide group; R 18 is: R 19 is alkyl, C 3 –C 7 cycloalkyl, or optionally substituted aryl; and each R e is independently hydrogen, lower alkyl, lower alkenyl, lower alkoxy, optionally substituted aryl, heteroaryl, aralkyl or heteroaralkyl; or two R e taken together form a three to seven membered aliphatic or aromatic ring which optionally contains at least one heteroatom, wherein when two R e are taken together in the formation of a ring containing unsaturation, then other R e may be absent.