Patent ID: 7081469

Claim:
A method for treatment of a solid cancerous tumor in a mammal wherein a composition of formula I is administered to said mammal in a dosage sufficient to damage new vasculature but insufficient to exhibit anti-mitotic activity: wherein: alk is an alkyl group; X is oxygen, sulfur, sulphinyl, sulphonyl, carbonyl (CO), thiocarbonyl (CS), sulphonyloxy, NH, iminomethylene (C═NH), N-hydroxyiminomethylene, N-alkoxyiminomethylene, dialkoxymethylene, 1,3-dioxolan-2yl, 1,1-ethenyl, a group CHR 3 or a bond; R 1 is hydrogen, alkylaminocarbonyl or alkoxycarbonyl; R 2 is hydrogen, alkoxycarbonyl, cyanomethyl, cyanoethyl, alkoxymethyl or acetoxymethyl; R 3 is hydrogen, hydroxy, alkoxy or amino; A is a substituted aromatic or substituted alkyl group; wherein the substituent on A is selected from phosphate, alkylphosphate, NHC(O)R 4, NR 5 C(O)R 4 , R 4 and R 5, which may be the same or different, are each an alkyl group substituted with one or more substituents selected from hydroxy, amino, alkylamino, guanidino, carboxyl, SO 3 H, sulfate and phosphate; and prodrugs and pharmaceutically acceptable salts, solvates and hydrates thereof.