Patent ID: 7144883

Claim:
A compound of the formula I or a pharmaceutically acceptable salt thereof, wherein: ring B is in which D is a five-membered heterocyclic or heteroaryl ring, said ring comprising one or two atoms selected from the group consisting of nitrogen, sulfur and oxygen, with the proviso that when D contains an oxygen atom, D is heteroaryl; W is —(CH); P is P and R 3 are bound to the same ring and are disposed in meta- or para-positions relative to each other; R 1 is (a) C 1-6 alkyl, (b) C 1-6 alkoxyalkyl, (c) straight or branched C 1-6 hydroxyalkyl, (d) straight or branched C 1-6 alkylhalides; or (e) a group Ar; Ar is (a) phenyl, (b) 1-naphthyl, (c) 2-naphthyl, (d) benzyl, (e) cinnamoyl, (f) a 5 to 7-membered, optionally aromatic, partially saturated or completely saturated, heterocyclic ring containing 1 to 4 heteroatoms, selected from oxygen, nitrogen and sulfur, or (g) a bicyclic ring system comprising at least one heterocyclic ring according to (f); wherein the group Ar is substituted in one or more positions with (a) H, X or Y, or (b) a 5 to 7-membered, optionally aromatic, partially saturated or completely saturated, heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulfur; R 2 is (a) H, (b) C 1-6 alkyl, (c) C 1-6 alkoxy, (d) straight or branched C 1-6 hydroxyalkyl, or (e) straight or branched C 1-6 alkylhalides; or R 1 and R 2 are linked to form a group (CH 2 ) 4 O; one of R 3 is a group X and Y are independently (a) H, (b) halogen, (c) C 1-6 alkyl, (d) —CF 3 , (e) hydroxy, (f) C 1-6 alkoxy, (g) C 1-4 alkenyl, (h) phenyl, (i) phenoxy, (j) benzyloxy, (k) benzoyl, (l) —OCF 3 , (m) —CN, (n) straight or branched C 1-6 hydroxyalkyl, (o) straight or branched C 1-6 alkylhalides, (p) —NH 2 , (q) —NHR 4 , (r) —NR 4 R 5 , (s) —NO 2 , (t) —CONR 4 R 5 , (u) —NHSO 2 R 4 , (v) —NR 4 COR 5 , (x) —SO 2 NR 4 R 5 , (z) —C(═O)R 4 , (aa) —CO 2 R 4 , (ab) —S(O) n R 4 wherein n is 0, 1, 2 or 3, (ac) —S—(C 1-6 )alkyl, or (ad) —SCF 3 ; R 4 and R 5 are independently (a) H, (b) C 1-6 alkyl, (c) C 3-7 cycloalkyl, or (d) Ar, as defined above for R 1 ; alternatively, R 4 and R 5 are linked to form a group (CH 2 ) 2 O, (CH 2 ) 4 O or (CH 2 ) 3-5 ; and R 6 is (a) H, or (b) straight of branched C 1-6 alkyl.