Patent ID: 8772304

Claim:
A compound of formula IA wherein: R 1 is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolopyridinyl, imidazopyridinyl, pyrazolopyridinyl or dihydropyrrolopyridinyl optionally substituted with oxo, wherein each heterocycle is optionally independently substituted with one to three groups selected from Ra, Rb and Rc; R 2 is C 1 -C 6 alkyl or C 3-6 cycloalkyl optionally substituted with C 1-3 alkyl; R 3 is H, —OH, halogen, —CN, C 1-6 alkoxy, —COOR 8 , —C(O)NR 8 R 9 or 5-6 membered heteroaryl ring which is optionally substituted with C 1-3 alkyl; R 4 , R 5 , and R 6 are each independently selected from (a) —H, (b) —OH, (c) halogen, (d) —CN, (e) —CF 3 , (f) C 1-6 alkyl optionally substituted with one to three —OH, fluorine, C 1-6 alkoxyl —N(R 8 )(R 9 ), or —C(O)N(R 8 )(R 9 ), (g) C 3-6 cycloalkyl (h) C 1-6 alkoxy optionally substituted with one to three —OH, fluorine, —OC 1-6 alkyl, or —OC 3-6 cycloalkyl (i) —S(O) n C 1-6 alkyl, (j) —S(O) 2 aryl (k) —S(O) 2 heterocycle (l) —CO 2 R 8 , (m) —SCF 3 , (n′) a5-6 membered heterocyclic ring; R 8 and R 9 are each independently selected from —H, C 1-6 alkyl, and 5-6 membered heterocyclic ring; Ra is selected from H, —NH 2 , —NH(C 1 -C 6 )alkyl, —NR 10 R 11 , —NH—C(O)C 1 -C 6 alkyl, NR 11 —C(O)C 1 -C 6 alkyl, —O(C 1 -C 8 )alkyl, —O(C 3 -C 6 )cycloalkyl, —S—(C 1 -C 6 )alkyl, —S(O)—C 1 -C 6 alkyl, —S(O) 2 —C 1 -C 6 alkyl, and —CH 2 —OH; Rb is selected from —H, —(C 1 -C 6 )alkyl, —O—(C 1 -C 6 )alkyl, —NH 2 , —CH 2 —OH, —C≡N, —CH 2 NH 2 and —C(O)OCH 3 ; Rc is selected from —H, —CH 3 and —OH; R 10 and R 11 are each independently selected from —H, C 1-6 alkyl-5-6 membered heterocyclyl, C 1-6 alkyl-5-6 membered heteroaryl optionally substituted with halogen and C 1-6 alkyl-aryl; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.