Patent ID: 7408071

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R 1 is phenyl optionally substituted with one or more groups selected from halogen, CN, CF 3 , OH, —NH 2 , C 3-6 cycloalkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 1-6 alkyl optionally substituted with OH, C 3-6 cycloalkyl, or —NH 2 , —(CH 2 ) m —NHC(═O)OC 1-6 alkyl, —(CH 2 ) m —NHC(═O)Ophenyl optionally substituted with halogen, —(CH 2 ) m —NHC(═O)R 8 and —NHC(═O)R 9 ; R 2 and R 3 are each independently hydrogen, methyl or hydroxymethyl; p is 0 or 1; m is 0 or 1; R 4 and R 6 are independently hydrogen, C 1-6 alkyl, C 1-4 alkoxy, CN, OH, NH 2 , benzyloxy, phenyl or CF 3 in which said phenyl is optionally substituted with one or more groups selected from halogen, CN, CF 3 and OCH 3 ; R 5 and R 5′ are each independently hydrogen, C 1-6 alkyl, or C 1-4 alkanol; R 7 is hydrogen, halogen, C 1-6 alkyl, C 1-4 alkoxy, CN, OH, NH 2 , N(CH 3 ) 2 , NO 2 , or CF 3 ; R 8 is C 1-6 alkyl or C 3-6 cycloalkyl in which each is optionally substituted with a group selected from halogen, CN, CF 3 and C 1-4 alkoxy; R 9 is —C 1-6 alkylNR 10 R 11 ; R 10 is hydrogen or C 1-6 alkyl; and R 11 is hydrogen, C 1-6 alkyl optionally substituted with OH, halogen, C 1-4 alkoxy, C 3-6 cycloalkyl, thienyl or C 1-4 alkylcarboxyl, —(CH 2 ) m C 3-6 cycloalkyl optionally substituted with phenyl or C 1-4 alkyl; —(CH 2 ) m phenyl optionally substituted with halogen, hydroxyl, C 1-4 alkyl or C 1-4 alkoxy; or R 10 and R 11 together with the nitrogen to which they are attached is azetidine, aziridine, pyrrolidine, piperidine, homopiperidine, homopiperazine, morpholine or thiomorpholine, in which each is optionally substituted with a group selected from halogen, C 1-6 alkyl and C 1-4 alkoxy; or a nontoxic pharmaceutically acceptable salt thereof.