Patent ID: 7695627

Claim:
A tangential flow filtration device for preparing a cell population enriched for leukocytes, comprising: a remover unit having a cross-flow chamber, a filtrate chamber and a filter disposed therebetween the filter having a retentate surface and a filtrate surface, the filter in fluid communication with the cross-flow chamber and the filtrate chamber; the cross-flow chamber having an inlet and an outlet, the inlet disposed to introduce the cell population comprising a sample of blood constituents comprising leukocytes into the cross-flow chamber and parallel to the retentate surface of the filter; and the outlet centrally disposed in a portion of the cross-flow chamber opposite the filter retentate surface; the filter having an average pore size ranging from about 1 to about 10 microns; such that flow of the sample of blood constituents across the filter enriches the cell population comprising the sample of blood constituents for leukocytes.