Patent ID: 7601721

Claim:
A compound of Formula I: wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are hydrogen, lower alkyl, or —C(O)R; in which R is NR 12 R 13 , where R 12 and R 13 are hydrogen or lower alkyl; or R 1 and R 2 , R 3 and R 4 , R 5 and R 6 , R 7 and R 8 , when taken together with the carbon to which they are attached, represent carbonyl; with the proviso that the maximum number of carbonyl groups is 2; R 9 is —NHSO 2 R 12 , —NHC(O)R 12 , or —OR 12 ; in which R 12 is lower alkyl optionally substituted with halo, hydroxyl, or CF 3 ; and R 10 is 2-methylbenzo-1,3-thiazol-5-yl, 2-cyclohexylbenzo-1,3-thiazol-5-yl, 2-phenylbenzo-1,3-thiazol-5-yl, or 2-phenylbenz-1,3-oxazol-5-yl; X is 5-[4-(trifluoromethyl)phenyl](1,2,4-oxadiazol-3-yl, 4,5-dihydroisoxazolyl, 1,3-oxazolinyl, 2,3-dihydro-1,2,4-oxadiazolyl, 4,5-dihydro-1,2,4-oxadiazolyl, 1,4-pyrazolinyl, or 4,5-dihydropyridinyl; Y is (CH 2 ) n , in which n is 0, 1, or 2; and Z is —N<, —NH—C(O)—N<, or —NH—C(O)—CH 2 —N<; or a pharmaceutically acceptable salt thereof.