Patent ID: 7968690

Claim:
An isolated agonist anti-trkC antibody comprising: (a) heavy chain CDRs (CDRHs) comprising: (i) a CDRH1 of the formula GYTFTSYXaaXaaH (SEQ ID NO:16), wherein Xaa at position 8 is R or W, and Xaa at position 9 is I, L, R, or M; (ii) a CDRH2 of the formula EIYPSNXaaRTNYNEKFXaaS (SEQ ID NO:17), wherein Xaa at position 7 is A, T, S, or G; and Xaa at position 16 is K or E, and (iii) a CDRH3 of the formula KYYYGNXaaXaaRSWYFDV (SEQ ID NO:18), wherein Xaa at position 7 is T or S; wherein Xaa at position 8 is R, Q, K, S, or Y; and (b) light chain CDRs (CDRL) comprising: (i) a CDRL1 of the formula RASESXaaDXaaYGISFXaaXaa (SEQ ID NO:19), wherein Xaa at position 6 is I or V; Xaa at position 8 is N or S; Xaa at position 14 is L or M; Xaa at position 15 is A, T, or N; (ii) a CDRL2 of the formula AASNXaaGS (SEQ ID NO:20), wherein Xaa at position 5 is R, L, or Q; and (iii) a CDRL3 of the formula QQSKXaaVPRT (SEQ ID NO:21), wherein Xaa at position 5 is T, A, S, or E; wherein the agonist anti-trkC antibody is not an antibody comprising (a) a heavy chain CDRs comprising a CDRH1 of SEQ ID NO:22, a CDRH2 of SEQ ID NO:23, and a CDRH3 of SEQ ID NO:24; and (b) light chain CDRs comprising a CDRL1 of SEQ ID NO:25, a CDRL2 of SEQ ID NO:26, and a CDRL3 of SEQ ID NO:27.