Patent ID: 7148378

Claim:
A method of treating a patient suffering from bipolar disorder comprising administering thereto a therapeutically effective amount of a compound for treating bipolar disorder, said compound having the formula: wherein R is aryl lower alkyl, and R is unsubstituted or is substituted with at least one electron withdrawing group or electron donating group; R 1 is lower alkyl and is unsubstituted or substituted with at least one electron withdrawing group or electron donating group; R 2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, halo, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, or Z—Y, R 3 is lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, halo, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl or ZY; wherein R 2 and R 3 may be unsubstituted or substituted with at least one electron withdrawing group or electron donating group, and wherein heterocyclic in R 2 and R 3 is furyl, thienyl, pyrazolyl, pyrrolyl, imidazolyl, indolyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, piperidyl, pyrrolinyl, piperazinyl, quinolyl, triazolyl, tetrazolyl, isoquinolyl, benzofuryl, benzothienyl, morpholinyl, benzoxazolyl, tetrahydrofuryl, pyranyl, indazolyl, purinyl, indolinyl, pyrazolindinyl, imidazolinyl, imidazolindinyl, pyrrolidinyl, furazanyl, N-methylindolyl, methylfuryl, pyridazinyl, pyrimidinyl, pyrazinyl, epoxy, aziridino, oxetanyl or azetidinyl; Z is O, S, or NR 6 ′; Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, and Y may be unsubstituted or substituted with an electron donating group or an electron withdrawing group, or ZY taken together is NR 4 NR 5 R 7 , NR 4 OR 5 , or ONR 4 R 7 ; R 6 ′ is hydrogen or lower alkyl and R 6 ′ may be unsubstituted or substituted with an electron withdrawing group or an electron donating group; R 4 and R 5 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, wherein R 4 and R 5 are independently unsubstituted or substituted with an electron withdrawing group or an electron donating group; and R 7 is COOR 8 , COR 8 , hydrogen, lower alkyl, aryl, or aryl lower alkyl wherein R 7 may be unsubstituted or substituted with an electron withdrawing group or electron donating group; R 8 is hydrogen or lower alkyl, or aryl lower alkyl, and the aryl or alkyl group may be unsubstituted or substituted with an electron withdrawing group or an electron donating group; and n is 1; wherein the electron withdrawing group and electron donating group are selected from the group consisting of halo, nitro, lower alkenyl, lower alkynyl, formyl, aryl, trifluoromethyl, aryl lower alkanoyl, lower alkoxy carbonyl, hydroxy, lower alkoxy, lower alkyl, mercapto, lower alkylthio and lower alkyldithio.