Patent ID: 7173041

Claim:
A composition comprising a polyglutamic acid-camptothecin conjugate having the formula: wherein: PG is polyglutamic acid polymer; Camptothecin is 20(S)-camptothecin or a biologically active 20(S)-camptothecin analog linked via the oxygen at position 20 of Camptothecin; wherein the 20(S)-camptothecin analog is of the formula wherein one or more of R 1 â€“R 5 is other than H; PG is attached to the moiety â€”NHâ€”(CH 2 ) 2 â€”C(O)-[Camptothecin] or the moiety â€”NHâ€”C(CH 3 )(H)â€”C(O)-[Camptothecin] through the Î»-carbonyl group of a monomeric unit of said polyglutamic acid polymer.