Patent ID: 7094900

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof wherein: A is X 1 and Y 1 together form the group —C(═O)N(R 5 )— wherein X 1 is NR 5 and Y 1 is C(═O) Z 1 is (a) NHC(═O)R 1 , or (b) NHC(═S)R 1 ; R 1 is (a) NH 2 , (b) NHC 1-4 alkyl, (c) C 1-4 alkyl, (d) C 2-4 alkenyl, (e) —CH 2 C(═O)C 1-4 alkyl, (f) OC 1-4 alkyl, (g) SC 1-4 alkyl, or (h) C 3-6 cycloalkyl; Each X, Y, and Z is independently selected from (a) H, (b) Cl, (c) F, or (d) CH 3 R 4 is (a) H, (b) C 1-4 alkyl, (c) OC 1-4 alkyl, (d) SC 1-4 alkyl, or (e) NHC 1-4 alkyl; R 5 is (a) H, (b) C 1-4 alkyl, or (c) —(CH 2 ) n —W 1 —(CH 2 ) n -Z 3 ; W 1 is (a) —CH 2 —, (b) —CH═CH—, (c) —C≡C—, or Z 3 is W 2 is (a) —O—, (b) —N(R 25 )—, or (c) —C(═O)—N(R 25 )—, wherein either the carbon or the nitrogen atom of the amide may be bound to a carbon atom of the phenyl ring of Z 3 ; R 22 is (CH 2 ) t NR 23 R 24 , H, halo, C 1-4 alkyl, —CN, —OH, —O—C 1-4 alkyl, —S(O) u C 1-4 alkyl, and —C(═O)NH 2 R 23 is H or C 1-4 alkyl; R 24 is is H, C 1-4 alkyl, —S(O) 2 —C 1-4 alkyl, —C(═O)—C 1-4 alkyl, —C(═NH)—NH 2 , —C(═O)—C(HR 26 )—NR 27 R 28 ; R 25 is H or C 1-4 alkyl; R 26 is H, C 1-4 alkyl which can be optionally substituted by —OH, —NH 2 , —NH—C(═NH)—NH 2 , —SH, —SCH 3 , —COOH, —C(O)NH 2 , and phenyl which can be optionally substituted with —OH, imidazole, indole; R 27 is H or C 1-4 alkyl; R 28 is H, C 1-4 alkyl, —S(O) 2 —C 1-4 alkyl, —C(═O)-C 1-4 alkyl, —C(═NH)—NH 2 , —C(═O)—C(HR 26 )—NR 27 R 27 t is 0, 1; u is 0, 1, 2; n is 1 or 2; and at each occurrence, alkyl, alkenyl, or cycloalkyl is optionally substituted with 1–3 halo, —OH, —OC 1-4 alkyl.