Patent ID: 8906849

Claim:
A method for treating Type-2 diabetes, obesity, or insulin-resistance syndrome, or for causing weight loss, in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of a PPF polypeptide to treat obesity, Type-2 diabetes, or insulin-resistance syndrome, or to cause weight loss, wherein the PPF polypeptide comprises the amino acid sequence of Formula (VII) (SEQ ID NO: 482): Xaa 1 Xaa 2 Pro Xaa 4 Pro Xaa 6 His Pro Xaa 9 Xaa 10 Xaa 11 Xaa 12 Xaa 13 Xaa 14 Xaa 15 Xaa 16 Xaa 17 Ala Xaa 19 Tyr Xaa 21 Xaa 22 Xaa 23 Leu Xaa 25 Xaa 26 Xaa 27 Xaa 28 Xaa 29 Xaa 30 Xaa 31 Thr Arg Gln Arg Tyr wherein: Xaa 1 is absent; Xaa 2 is absent; Xaa 4 is Lys; Xaa 6 is Glu; Xaa 9 is Gly; Xaa 10 is Glu; Xaa 11 is Asp; Xaa 12 is Ala; Xaa 13 is Ser or Pro; Xaa 14 is Pro, Ala, or Ser; Xaa 15 is Glu; Xaa 16 is Glu; Xaa 17 is Leu; Xaa 19 is Arg, Lys; Xaa 21 is Tyr; Xaa 22 is Ala; Xaa 23 is Ser; Xaa 25 is Arg; Xaa 26 is Ala; Xaa 27 is Tyr; Xaa 28 is Ile; Xaa 29 is Asn; Xaa 30 is Leu; and Xaa 31 is Ile.