Patent ID: 7528274

Claim:
A compound of Template III-V: A 1 , A 2 , A 3 , and A 4 are each independently selected from the group consisting of CH, CR 5 , CR 6 , CR 7 and CR 8 ; R 5 , R 6 , R 7 and R 8 are independently selected from the group consisting of halogen, CF 3 , alkyl, alkoxy, aryl, NO 2 , alkylthio, amino, acylamino, arylamino, acylthio, acyl, acyloxy, hydroxy, mercapto, cycloalkyl, heterocycloallcyl, heteroaryl and thioamido; each of which is optionally substituted with a member independently selected from the group consisting of lower alkyl, aryl, acyl, halogen, alkylhalo, hydroxy, amino, alkoxy, alkylamino, acylamino, thioamido, acyloxy, aryloxy, arylamino, aryloxyallcyl, mercapto, thia, aza, oxo, alkoxycarbonyl, alkylaminocarbonyl, saturated and unsaturated cyclic hydrocarbons and heterocycle; Z 1 is a member selected from the group consisting of O, S, and NR 4 ; R 11 is a member selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, cycloatkylallcyl, heterocycloalkyl, and heteroaryl; each of which is optionally substituted with a member independently selected from the group consisting of lower alkyl, aryl, acyl, halogen, alkylhalo, hydroxy, amino, alkoxy, alkylamino, acylamino, thioamido, acyloxy, aryloxy, arylamino, aryloxyalkyl, mercapto, thia, aza, oxo, alkoxycarbonyl, alkylaminocarbonyl, saturated and unsaturated cyclic hydrocarbons and heterocycle; and wherein R 11 does not contain a cationic group that cannot be neutralized by loss of a proton near physiological pH; R 4 is a member selected from the group consisting of H, alkyl, ailcoxy, aryl, and acyl; each of which is optionally substituted with a member independently selected from the group consisting of lower alkyl, aryl, acyl, halogen, alkylhalo, hydroxy, amino, alkoxy, alkylamino, acylamino, thioamido, acyloxy, aryloxy, arylamino, aryloxyalkyl, mercapto, thia, aza, oxo, alkoxycarbonyl, alkylaminocarbonyl, saturated and unsaturated cyclic hydrocarbons and heterocycle; R 16 is H; R 10 is a member selected from the group consisting of alkylene, alkylene-C(O), phenylene, cycloalkylene, aikylcycloalkylene, cycloalkylenealkyl; wherein L 1 and L 2 are members independently selected from the group consisting of a bond and an alkylene chain of up to 4 carbons; each of which is optionally substituted with a member independently selected from the group consisting of lower alkyl, aryl, acyl, halogen, alkylhalo, hydroxy, amino, alkoxy, alkylamino, acylamino, thioamido, acyloxy, aryloxy, arylamino, aryloxyalkyl, mercapto, thia, aza, oxo, alkoxycarbonyl, alkylaminocarbonyl, saturated and unsaturated cyclic hydrocarbons and heterocycle; R 17 is H; R 12 , R 13 , R 14 and R 15 are members independently selected from the group consisting of H, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkylamino, arylamino, alkylthio, acyl, acylamino, acyloxy, acylthio, halogen, hydroxy, amino, thioamido, and mercapto; and pharmaceutically acceptable salts thereof.