Patent ID: 7084171

Claim:
A therapeutic method for treating a Marfan's syndrome, fibrosis, or senile dementia, comprising administering to a mammal in need of such therapy, an effective amount of a compound of formula VI: R 6 is (C 1 –C 6 )alkyl, or aryl, optionally substituted by 1, 2, or 3 V; R 7 is phenyl, optionally substituted by 1, 2, or 3 V; or R 7 is (C 1 –C 12 )alkyl, halo(C 1 –C 12 )alkyl, (C 3 –C 6 )cycloalkyl, (C 1 –C 6 )alkylcyclo(C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkenyl, or (C 1 –C 6 )alkyl(C 3 –C 6 )cycloalkenyl; R 8 is hydrogen or phenyl, optionally substituted at the 2-position with R j , and optionally substituted by 1, 2, or 3 V; R 9 is hydrogen, nitro, halo, aryl, heteroaryl, aryl(C 1 –C 3 )alkyl, heteroaryl(C 1 –C 3 )alkyl, halo(C 1 –C 12 )alkyl, cyano(C 1 –C 12 )alkyl, (C 1 –C 4 )alkoxycarbonyl(C 1 –C 6 )alkyl, (C 1 –C 12 )alkyl, (C 3 –C 6 )cycloalkyl, (C 1 –C 6 )alkylcyclo(C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkenyl, or (C 1 –C 6 )alkyl(C 3 –C 6 )cycloalkenyl, wherein any aryl or heteroaryl may optionally be substituted by 1, 2, or 3, V; or R 9 and R j together are —CH 2 CH 2 —, —S—, —O—, —N(H)—, —N[(C 1 –C 6 )alkyl]—, —OCH 2 —, —OC[(C 1 –C 6 )alkyl] 2 —, or —CH═CH—; — is a single bond or is —C(B)(D)-, wherein B and D are each independently hydrogen, (C 1 –C 6 )alkyl, or halo; V is OPO 3 H 2 , (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, mercapto, (C 1 –C 4 )alkylthio, halo trifluoromethyl, pentafluoroethyl, nitro, N(R n )(R o ), cyano, trifluoromethoxy, pentafluoroethoxy, benzoyl, hydroxy, —(CH 2 ) 0-4 C(═O)(C 1 –C 6 )alkyl, -UC(═O)(C 1 –C 6 )alkyl, benzyl, —OSO 2 (CH 2 ) 0-4 CH 3 , -U(CH 2 ) 1-4 COOR p , —(CH 2 )-4C(═O)R k , -U(CH 2 ) 2-4 OR p , —(CH 2 ) 0-4 OR p , -U(CH 2 ) 1-4 C(═O)R k , —(CH 2 ) 0-4 C(O)R k , -U(CH 2 ) 1-4 R k , —(CH 2 ) 0-4 R k , or -U(CH 2 ) 2-4 OC(═O)R p ; wherein U is O, N(R m ), or S; Z is —(CH 2 )1-3-, —O—, —OCH 2 —, —CH 2 O—, —C(═O)O—, —N(R q )—, C═O, or a covalent bond; R k is amino, optionally substituted with one or two (C 1 –C 6 )alkyl; or an N-heterocyclic ring optionally containing 1 or 2 additional N(R 1 ), S, or nonperoxide O, wherein RI is H (C 1 –C 6 )alkyl, phenyl, or benzyl; R n and R o are independently hydrogen, (C 1 –C 6 )alkyl, phenyl, benzyl, or (C 1 –C 6 )alkanoyl; or R n and R o together with the nitrogen to which they are attached are a 3, 4, 5, or 6 membered heterocyclic ring; R p is H or (C 1 –C 6 )alkyl; and R m and R q are independently hydrogen, (C 1 –C 6 )alkyl, phenyl, benzyl, or (C 1 –C 6 )alkanoyl; the compound is MER25; or a pharmaceutically acceptable salt thereof.