Patent ID: 7091203

Claim:
A method for treatment of cardiovascular diseases comprising administering to a mammal in need thereof an effective amount of a compound of Formula (I) in which R 1 represents straight-chain or branched alkyl having up to 4 carbon atoms, R 2 represents straight-chain or branched alkyl having up to 4 carbon atoms or represents cyclopentyl, R 3 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms, R 4 and R 5 are identical or different and represent hydrogen, (C 1 –C 6 )-alkoxy or hydroxyl or represent (C 1 –C 8 )-alkyl which is optionally substituted, up to 3 times, identically or differently, by hydroxyl or (C 1 –C 6 )-alkoxy or by radicals of the formulae in which R 6 and R 7 are identical or different and denote hydrogen or (C 1 –C 6 )-alkyl, and/or, for its part, (C 1 –C 8 )-alkyl is optionally substituted by phenyl or phenoxy which, for their part, are optionally substituted, once to three times, identically or differently, by halogen, hydroxyl, (C 1 –C 6 )-alkoxy or (C 1 –C 6 )-alkyl or by a radical of the formula —SO 2 NR 8 R 9, in which R 8 and R 9 are identical or different and denote hydrogen or (C 1 –C 6 )-alkyl, or R 4 represents hydrogen or methyl, and R 5 represents radicals of the formulae or represents phenyl which is optionally substituted, up to 3 times, identically or differently, by halogen, acetyl or (C 1 –C 6 )-alkoxy or by radicals of the formulae —NR 10 R 11 or —CH 2 —P(O)(OR 12 )(OR 3 ), in which R 10 and R 11 are identical or different and denote hydrogen or (C 1 –C 4 )-alkyl, R 12 and R 13 are identical or different and denote hydrogen or (C 1 –C 6 )-alkyl, or R 4 and R 5, together with the nitrogen atom to which they are bonded, form radicals of the formulae in which R 14 and R 15 are identical or different and denote hydroxyl, hydrogen or (C 1 –C 4 )-alkyl which is optionally substituted by hydroxyl, or R 14 denotes hydrogen, and R 15 denotes a radical of the formula or R 14 and R 15 together form a radical of the formula ═N—O—CH 3, R 16 denotes hydrogen or (C1–C8)-alkyl which is optionally substituted by hydroxyl, or a 5- to 6-membered, aromatic heterocycle having up to 3 heteroatoms from the series S, N and/or O, or the salts, N-oxides and isomeric forms thereof.