Patent ID: 7053175

Claim:
Synthetic peptides in linear form, or cyclized by means of inter-cysteine disulphide bridges, having the general formula (I): Δ-Z-Trp Gly Cys (residues 5 to 7 of SEQ ID NO: 1)-Θ-Cys Tyr Thr Ser (residues 13 to 16 of SEQ ID NO: 1)-Ω (I) wherein: Δ is selected from the group consisting of a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH 3 CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group and an amine functional group, Z is a peptide sequence selected from the group consisting of: Leu Leu Ser Ser (residues 1 to 4 of SEQ ID NO: 3), Leu Leu Asn Ser (residues 1 to 4 of SEQ ID NO: 6), Arg Leu Asn Ser (residues 1 to 4 of SEQ ID NO: 16), Ala Leu Glu Thr Leu Leu Gln Asn Gln Gln Leu Leu Asn Ser (residues 1 to 14 of SEQ ID NO: 11), Ala Leu Glu Thr Leu Leu Gln Asn Gln Gln Leu Leu Asp Leu (residues 1 to 14 of SEQ ID NO: 13), Ala Leu Glu Thr Leu Leu Gln Asn Gln Gln Leu Leu Asn Ile (residues 1 to 14 of SEQ ID NO: 12), Leu Asn Gln Gln Arg Leu Leu Asn Ser (residues 1 to 9 of SEQ ID NO: 14), and Arg Ala Leu Glu Thr Leu Leu Asn Gln Gln Arg Leu Leu Asn Ser (residues 1 to 15 of SEQ ID NO: 15), Θ is a peptide sequence selected from the group consisting of: Arg Gly Arg Leu Val (residues 8 to 12 of SEQ ID NO: 2), Arg Gly Lys Leu Ile (SEQ ID NO: 17), Arg Gly Lys Leu Val (SEQ ID NO: 18), and Lys Gly Arg Leu Val (residues 8 to 12 of SEQ ID NO: 3), Ω, attached to the —CO— group of Ser, is selected from the group consisting of: a hydroxyl group and a peptide sequence of formula Val-Ψ, Val Arg Trp Asn Glu Thr-Ψ(residues 27-32 of SEQ ID NO: 11), Val Gln Trp Asn Glu Thr-Ψ(residues 27 to 32 of SEQ ID NO: 1), and Val Gln Trp Asn Ser Thr-Ψ(residues 27 to 32 of SEQ ID NO: 4), wherein Ψ, attached to the —CO— residue of Val or Thr, is selected from the group consisting of a OH group, a NH 2 group, and an alkoxy radical comprising from 1 to 6 carbon atoms.