Patent ID: 8226598

Claim:
A coupling syringe system comprising: a first syringe including a first syringe barrel having a first syringe distal end, the first syringe further including a first syringe tip with an integral male end portion, an inner surface of the male end portion forming a single fluid passage, and a locking ring at the first syringe distal end, wherein the locking ring is spaced from an outer surface of the male portion; a first syringe plunger slidably disposed within the first syringe barrel and configured to move to a position at the first syringe distal end, a first volume of a first composition is retained within the first syringe barrel including the first syringe tip; a second syringe including a second syringe barrel having a second syringe distal end, the second syringe further including at the second syringe distal end a second syringe tip with an integral female end portion coupled with the second syringe barrel and one or more exteriorly protruding members adapted to detachably fit the locking ring, wherein the female end portion has an opening defined by an opening wall, which supports the one or more exteriorly protruding members; a second syringe plunger slidably disposed within the second syringe barrel and configured to move to a position at the second syringe distal end, a second volume of a second composition is retained within the second syringe barrel; wherein the first syringe and the second syringe are each sized to contain a single dose; and wherein, when the first and second syringes are coupled, the male end portion is received by the opening of the female end portion at the first and second syringe distal ends, the single fluid passage of the integral male end portion extends into the female end portion between the first and second syringe barrels, and the opening wall and the one or more exteriorly protruding members are received by the spacing between the locking ring and the outer surface of the male end portion, thereby allowing for a single, fluid tight attachment site configured for back and forth transfer and mixing of the first and second volumes of the first and second compositions between the first and second syringes through the single fluid passage, wherein a mixing volume including the first and second volumes is substantially fully transitioned between the first and second syringes in corresponding first and second mixing configurations: in the first mixing configuration, the mixing volume is substantially fully retained within the first syringe barrel, and in the second mixing configuration, the mixing volume is substantially fully retained within the second syringe barrel.