Patent ID: 7651995

Claim:
A method of enhancing the absorption of an active macromolecular principle which is a polypeptide or protein, polynucleotide or polysaccharide in a patient, which method comprises orally administering to said patient a composition comprising an aromatic alcohol absorption enhancer chosen from propyl gallate, butylated hydroxy toluene (BHT), butylated hydroxy anisole (BHA) and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, wherein the composition is coated with an enteric coating which becomes permeable at a pH of from 3 to 7, and wherein when the aromatic alcohol is propyl gallate or an analogue or derivative thereof, the composition further comprises a solubilization aid capable of increasing the solubility of the aromatic alcohol absorption enhancer in aqueous media.