Patent ID: 8637523

Claim:
A compound of formula (I) including pharmaceutically acceptable salts thereof, wherein R 1 is a nitrile group, or is a five- or six-membered heteroaromatic ring containing from one to three heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein said heteroaromatic ring is optionally substituted with one or two groups selected from halo, haloC 1-6 alkyl, hydroxyl, amino, C 1-6 alkoxy, and C 1-6 alkyl; A is selected from O and CH 2 , or is a bond; B-D-E is —CH 2 —CH═CH—CH 2 — (cis), —CH 2 —CH═CH—CH 2 — (trans), —(CH 2 ) 3 —, —(CH 2 ) 4 —. —CH 2 —CH(OH)—CH 2 —CH 2 —, —CH 2 —CH 2 —CH(OH)—CH 2 —, —CH 2 —CH 2 —N(R 3 )—CH 2 —CH 2 —, or —CH 2 —CH 2 —O—CH 2 —CH 2 —; F is selected from O and NR 3 , or is a bond; G is selected from —CH 2 —, —CH 2 —CH 2 —, NR 3 , and —N(R 3 )—CH 2 —; S, T, and U are independently selected from carbon and nitrogen, with the proviso that no more than one of S, T, and U is nitrogen; R 2 is optionally one, two, or three of the following: halogen, C 1-4 alkoxy, OCF 3 , C 1-4 alkyl, CN; R 3 is independently C 1-4 alkyl or hydrogen.