Patent ID: 7858623

Claim:
A compound of formula I R—X—W—Y—R 1 I enantiomers, diastereomers, salts and N-oxides thereof, wherein R is Z is selected from N or CR 7 ; Z 1 is selected from N or CR 7 ; W is an substituted or unsubstituted phenyl, X is O; Y is —NR a C(═O)—(CR 3 R 4 ) p —; R a is selected from H, alkyl, heterocyclyl, aryl, arylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; wherein R a is optionally substituted; R 1 is wherein R b is independently selected at each occurrence from H, optionally substituted arylalkyl, optionally substituted C 1-6 -alkyl, and optionally substituted C 6-10 aryl; wherein R c is one or more substituents selected from H, methyl, isopropyl, and tert-butyl, R 3 and R 4 are each independently selected from H, alkyl, aryl, and heterocyclyl, R 7 is selected from H, halo, and alkyl; R 8 * is one or more substituents independently selected at each occurrence from —NR a C(═O)—R 5 , R 5 is independently selected at each occurrence from H, alkyl, heterocyclylalkyl, cycloalkylalkyl, aryl, and heterocyclyl; and p is 0, 1, 2, or 3; wherein each alkyl, aryl, heteroaryl, cycloakyl, alkenyl, alkynyl, heterocyclyl, and alkoxy moiety of any R, R 1 , R 3 , R 4 , R 5 , R 7 , R 8 * and R a is optionally independently substituted with one or more groups independently selected at each occurrence from halo, oxo, —(C 1 -C 6 )alkylamino, —NH—N═NH, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkyl amino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, heterocyclic, and heteroaryl.