Patent ID: 8481541

Claim:
A compound of formula I wherein: Y is C(R 1 ) 2 (C(R 1′ ) 2 ) m m is 0 or 1; each R 1 is H or R 1a ; each R 1a is independently lower alkyl, lower alkoxy, phenyl, benzyl, heteroaryl, cycloalkyl, heterocycloalkyl, or cycloalkyl lower alkyl, optionally substituted with one or more R 1a′ ; R 1a′ is halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower hydroxyalkyl, oxo, hydroxy, or cyano; each R 1′ is independently H, lower alkyl, or lower haloalkyl; R 2 is independently H or R 2a ; R 2a is independently lower alkyl, lower haloalkyl, lower alkoxy, lower hydroxyalkyl, cyano lower alkyl, cycloalkyl, or heterocycloalkyl; or R 2a and R 1a come together to form a ring, optionally substituted with one or more halogen, lower alkyl, cyano, cyano lower alkyl, hydroxy, lower haloalkyl, lower hydroxyalkyl, lower alkoxy, lower alkylamino, or lower dialkylamino; R 3 is independently H or R 3a ; R 3a is independently lower alkyl, lower haloalkyl, lower alkoxy, lower hydroxyalkyl, cyano lower alkyl, C(═O)R 3a′ or S(═O) 2 R 3a′ ; each R 3a′ is independently H or lower alkyl; Q is H, halogen, hydroxy, cyano or Q′; Q′ is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, phenyl, cycloalkenyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q a ; Q a is Q b or Q c ; Q b is halogen, oxo, hydroxy, —CN, —SCH 3 , —S(O) 2 CH 3 , or —S(═O)CH 3 ; Q c is Q d or Q e ; or two Q a come together to form a bicyclic ring system, optionally substituted with one or more Q b or Q c ; Q d is —O(Q e ), —S(═O) 2 (Q e ), —C(═O)N(Q e ) 2 , —S(O) 2 (Q e ), —C(═O)(Q e ), —C(═O)O(Q e ), —N(Q e ) 2 ; —N(Q e )C(═O)(Q e ), —N(Q e )C(═O)O(Q e ), or —N(Q e )C(═O)N(Q e ) 2 ; each Q e is independently H or Q e′ ; each Q e′ is independently lower alkyl, phenyl, benzyl, lower haloalkyl, lower alkoxy, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q f ; Q f is Q g or Q h ; Q g is halogen, hydroxy, cyano, oxo, or —C(═O)(Q h ); Q h is lower alkyl, lower haloalkyl, lower alkoxy, amino, phenyl, benzyl, cycloalkyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q i ; and Q i is halogen, hydroxy, cyano, lower alkyl, lower haloalkyl, or lower alkoxy; or a pharmaceutically acceptable salt thereof.