Patent ID: 7767815

Claim:
A compound of formula I: or a pharmaceutically acceptable salt, or ester thereof, wherein: J 1 is N; J 2 , and J 3 are independently C; is a single or double bond; R 1 is phenyl optionally substituted with at least one R 8 ; X is —NR 5 R 6 ; Z is S; R 2 and R 3 are each independently H; R 4 is H; w is an integer ranging from 1-2; R 5 is selected from the group consisting of H, —NH 2 , alkyl, alkenyl, alkynyl, and cycloalkyl groups optionally substituted with at least one R 8 ; R 6 and R 7 are independently selected from the group consisting of H and alkyl, alkenyl, alkynyl, and cycloalkyl, R 8 is selected from the group consisting of H, halo, —OR 9 , NO 2 , —CN, —NR 9 C(O)R 10 , —NR 9 SO 2 R 11 , —NR 9 R 10 , —C(O)R 10 , —C(O)NR 5 R 6 , S(O 2 )NR 5 R 6 , and alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, cycloalkyl, cycloalkoxy, aryl, aryloxy, and arylalkyl, groups optionally substituted with at least one of halo, —CN, —NO 2 , —OR 6 , —SR 11 , —NR 5 R 6 , —C(O)R 6 , —C(O 2 )R 6 , —OC(O)R 6 , —C(O)NR 6 R 7 , —N(R 6 )C(O)R 6 , —OS(O 2 )R 11 , —S(O 2 )R 11 , —S(O 2 )NR 5 R 6 , —N(R 6 )S(O 2 )R 11 , —N(R 6 )C(O)NR 5 R 6 , and —NR 9 SO 2 R 11 ; R 9 is selected from the group consisting of H, and alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and arylalkyl, groups optionally substituted with at least one of halo, —CN, —NO 2 , —OR 6 , —SR 11 , —NR 5 R 6 , —C(O)R 6 , —C(O 2 )R 6 , —OC(O)R 6 , —C(O)NR 6 R 7 , —N(R 6 )C(O)R 6 , —OS(O 2 )R 11 , —S(O 2 )R 11 , —S(O 2 )NR 5 R 6 , —N(R 6 )S(O 2 )R 11 , and —N(R 6 )C(O)NR 5 R 6 ; R 10 is selected from the group consisting of H and alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, cycloalkyl, cycloalkoxy, aryl, aryloxy, and arylalkyl, groups optionally substituted with at least one of halo, —CN, —NO 2 , —OR 6 , —SR 11 , —NR 5 R 6 , —C(O)R 6 , —C(O 2 )R 6 , —OC(O)R 6 , —C(O)NR 6 R 7 , —N(R 6 )C(O)R 6 , —OS(O 2 )R 11 , —S(O 2 )R 11 , —S(O 2 )NR 5 R 6 , —N(R 6 )S(O 2 )R 11 , and —N(R 6 )C(O)NR 5 R 6 ; and R 11 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and arylalkyl, groups optionally substituted with at least one R 8 .