Patent ID: 8367681

Claim:
A compound of Formula (I): wherein the bicyclic ring system containing Z 1 -Z 4 is aromatic; Z 1 and Z 3 are N; Z 2 is C; and Z 4 is CR 5 ; where R 5 can be H or R 1 ; R 1 is H, halo, CN, optionally substituted C1-C4 alkyl, or optionally substituted C1-C4 alkoxy; R 2 is H, halo, CN, or optionally substituted C1-C4 alkyl; R 3 and R 4 are independently selected from H and optionally substituted C1-C10 alkyl; X is NR 6 , O, or S, where R 6 is H or an optionally substituted group selected from C1-C4 alkyl, C2-C4 alkenyl, and C2-C4 alkynyl; Y is O or S or NR 10 ; R 10 is selected from H, CN, optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, optionally substituted C2-C4 alkynyl, optionally substituted C1-C4 alkoxy, or —NR 7 R 8 , where R 7 and R 8 are independently selected from H, optionally substituted C1-C10 alkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, and optionally substituted heteroarylalkyl, or R 7 and R 8 taken together with the N of —NR 7 R 8 can form an optionally substituted 5-8 membered ring that optionally contains an additional heteroatom selected from N, O and S as a ring member; W is optionally substituted aryl, optionally substituted heteroaryl, —OR 7 , —NR 7 R 8 , or optionally substituted heterocyclyl, wherein n is 0, 1 or 2, each R 7 and R 8 are each independently selected from H, optionally substituted C1-C10 alkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, and optionally substituted heteroarylalkyl; wherein R 7 and R 8 in NR 7 R 8 can be taken together along with N to form a 5-8 membered ring that can be optionally substituted, and can optionally contain an additional heteroatom selected from N, O and S as a ring member; or a pharmaceutically acceptable salt thereof.