Patent ID: 8536164

Claim:
A compound of Formula I: wherein X and Y are independently ═N—, —NR 1 —, CR 1 , or —S—, provided that at least one of X and Y is CR 1 ; Ring A is a 4- to 7-membered cycloalkyl or heterocycloalkyl or a 5- to 6-membered heteroaryl, wherein up to 2 carbon atoms are replaced with a heteroatom selected from ═N—, —NR 2 —, —O—, —S and any remaining carbon atom may be substituted with R 3 as valency allows; Each R 1 is independently H, C 1-4 alkyl, C 3-6 cycloalkyl, —CF 3 , —(CH 2 ) 1-3 CF 3 , 4- to 10-membered heterocycloalkyl, wherein said heterocycloalkyl may be substituted with up to two substituents independently selected from halogen, OH, oxo, cyano, C 1-6 alkyl, or C 1-6 alkyl-O—C 1-6 alkyl; Each R 2 is independently H, C 1-6 alkyl, C 4-10 -bicycloalkyl, —(CH 2 ) t —CN, —SO 2 C 1-6 alkyl, —SO 2 (CH 2 ) t C 3-6 cycloalkyl, —C 1-6 alkyl-O—C 1-6 alkyl, —C 1-6 alkyl-C(O)O—C 1-6 alkyl, —C 3-6 cycloalkyl-C(O)O—C 1-6 alkyl, —C(O)—(O) u —C 1-6 alkyl, —C(O)—C 1-6 alkyl-O—C 1-6 alkyl, —C(O)—(O) u —(CH 2 ) t —(C 6-10 aryl), —(CH 2 ) t —(C 6-10 aryl), —C(O)—(O) u —(CH 2 ) t -(5- to 10-membered heteroaryl), —(CH 2 ) t —C(O)—NR 5 R 6 , —(CH 2 ) t -(5- to 10-membered heteroaryl), —C(O)—(O) u —(CH 2 ) t -(3- to 10-membered heterocycloalkyl), —(CH 2 ) t -(4- to 10-membered heterocycloalkyl), —C(O)—(O) u —(CH 2 ) t -(3- to 10-membered cycloalkyl), or —(CH 2 ) t -(3- to 10-membered cycloalkyl), wherein said aryl, heteroaryl, cycloalkyl, and heterocycloalkyl of R 2 may be substituted with up to two substituents independently selected from halogen, OH, cyano, C 1-6 alkyl, or C 1-6 alkyl-O—C 1-6 alkyl, and wherein any alkyl, cycloalkyl, and heterocycloalkyl of R 2 may be further substituted with oxo where valency allows; Each R 3 is independently absent, C 1-3 alkyl, halogen, oxo, —NR 5 R 6 , or —OR 5 ; Each R 4 is independently halogen, —CF 3 , C 1-3 alkyl, —(CH 2 ) t —C 3-4 cycloalkyl, —(CH 2 ) t —O—C 1-3 alkyl, —(CH 2 ) t -cyano, or —(CH 2 ) t -hydroxy; Each R 5 is independently H or C 1-6 alkyl; Each R 6 is independently H or C 1-6 alkyl; R 7 is H, halogen, or C 1-3 alkyl; n is 0, 1, or 2; Each t is independently 0, 1 or 2; and Each u is independently 0 or 1; or a pharmaceutically acceptable salt thereof.