Patent ID: 7776872

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: X is: —O—; D is an optional oxygen; A is N and E, G, J, Y and Z are CR a ; R 1 is: alkyl; alkenyl; alkynyl; cycloalkyl; cycloalkenyl; halo; haloalkyl; or hydroxyalkyl; each R a is independently: hydrogen; alkyl; alkenyl; amino; aminosulfonyl; halo; amido; haloalkyl; alkoxy; hydroxy; haloalkoxy; nitro; hydroxyalkyl; alkoxyalkyl; hydroxyalkoxy; alkynylalkoxy; alkylsulfonyl; arylsulfonyl; cyano; aryl; heteroaryl; heterocyclyl; heterocyclylalkoxy; aryloxy; heteroaryloxy; aralkyloxy; heteroaralkyloxy; optionally substituted phenoxy; —C≡C—R b —; —(CH 2 ) m —(Z) n —(CO)—R c ; —(CH 2 ) m —(Z) n —SO 2 —(NR d ) n —R c ; wherein m and n each independently is 0 or 1, Z is O or NR d , R b is hydrogen; alkyl; aryl; aralkyl; heteroaryl; heteroaralkyl; hydroxyalkyl; alkoxyalkyl; alkylsulfonylalkyl; aminoalkyl; cyanoalkyl; alkylsilyl, cycloalkyl, cycloalkylalkyl; heterocyclyl; and heterocyclylalkyl; R c is hydrogen, alkyl, hydroxy, alkoxy, amino, hydroxyalkyl or alkoxyalkyl, and each R d is independently hydrogen or alkyl; R 6 is: hydrogen; alkyl; halo; haloalkyl; amino; or alkoxy; R 7 and R 8 each independently is: hydrogen; alkyl; cycloalkyl; cycloalkylalkyl; haloalkyl; haloalkoxy; hydroxyalkyl; alkoxyalkyl; alkylsulfonyl; alkylsulfonylalkyl; aminocarbonyloxyalkyl; hydroxycarbonylalkyl; hydroxyalkyloxycarbonylalkyl; aryl; aralkyl; arylsulfonyl; heteroaryl; heteroarylalkyl; heteroarylsulfonyl; heterocyclyl; heterocyclylalkyl; or —(C═O)—R e ; wherein R e is alkyl, alkoxy, cycloalkyl, cycloalkoxy, cycloalkylalkyl, cycloalkylalkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aralkyl, aralkoxy, heteroaralkyl, heteroaralkoxy, —(CH 2 ) p —C(═O)—R f , —(CH═CH)—C(═O)—R f , or —CH(NH 2 )—R g wherein R f is hydrogen, hydroxy, alkyl, alkoxy, cycloalkyl, cycloalkoxy, cycloalkylalkyl, cycloalkylalkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aralkyl, aralkoxy, heteroaralkyl, heteroaralkoxy, or amino; p is 2 or 3; R g is hydrogen, alkyl, hydroxyalkyl, aminoalkyl, optionally substituted phenyl, benzyl, guanidinylalkyl, carboxyalkyl, amidoalkyl, thioalkyl or imidazolalkyl.