Patent ID: 8101621

Claim:
A compound of general formula I: wherein: n 1 is 0 or 1; n 2 is 0 or 1; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; R e is hydrogen atom or lower alkyl which may be substituted; with regard to R a1 , R a1 ′, R a2 , R a2 ′, R b1 , R b1 ′, R b2 and R b2 ′, two groups selected from four groups consisting of (i) either one of R a1 and R a1 ′, (ii) either one of R a2 and R a2 ′, (iii) either one of R b1 and R b1 ′, and (iv) either one of R b2 and R b2 ′, are combined to form —(CH 2 ) n — where n is 1, 2 or 3; and among R a1 , R a1 ′, R a2 , R a2 ′, R b1 , R b1 ′, R b2 and R b2 ′, the groups which do not form —(CH 2 ) n — are each independently hydrogen atom or lower alkyl which may be substituted; X 1 is N; X 2 is CH; X 3 is CH; X 4 is N; Y 1 , Y 2 , and Y 3 are each independently CH or N; however, if Y 1 is CH and R e is hydrogen atom, then the two hydrogen atoms may be substituted with oxo; W is the following residue: wherein: W 1 is CH; W 2 is CH; and W 3 is N; or a pharmaceutically acceptable salt or ester thereof.