Patent ID: 7105495

Claim:
A method for modulating the immunostimulatroy effect of a 5′-CpG-3′ dinucleotide containing compound, wherein C is cytosine and G is guanosine or a substituted guanosine, by introducing an immunomodulatory moiety at a position either 5′ or 3′ to the CpG dinucleotide, wherein the immunomodulatory moiety is selected from the group consisting of abasic nucleoside, 1,3-propanediol linker, nitropyrrole, nitroindole, deoxyuridine, inosine, isoguanosine, 2-aminopurine, nebularine, 7-deazaguanosine. 4-thiodeoxyuridine, 4-thiothymidine, d-isoguanosine, d-iso-5-methylcytosine, P-base, and 3′—3′ linkage, and wherein the compound is 12 to 35 nucleotides in length and wherein the compound does not have antisense activity.