Patent ID: 7749994

Claim:
A compound of formula I: wherein ring A is a 5, 6 or 7 member ring carbocycle or heterocycle; X, Y and Z are independently absent, CR 4 R 4′ , NR 5 , S, SO, SO 2 or O; wherein at least one of X, Y and Z is not absent; or X and Y together are CR 4 ═CR 4 ; or Y and Z together are CR 4 ═CR 4 ; R a and R b are independently H or a protecting group; R c is H, hydroxyl, halogen, alkyl, haloalkyl; R 1 is H, hydroxyl, halogen, amino, or is alkyl, acyl, alkoxy or alkylthio optionally substituted with hydroxyl, halogen, carbonyl, thiocarbonyl, amino, carboxyl and alkoxy; R 2 is H, halogen, hydroxyl, mercapto, amino, alkyl, a carbocycle or a heterocycle, wherein said alkyl, carbocycle and heterocycle are optionally substituted with halogen, hydroxyl, mercapto, amino, carboxyl, alkyl, a carbocycle or a heterocycle and wherein one or more CH 2 groups of an alkyl group is optionally replaced with —O—, —S—, —S(O)—, —S(O) 2 —, —N(R 5 )—, —C(O)—, —C(S)—, —C(O)—NR 5 —, —NR 5 —C(O)—, —SO 2 —NR 5 —, —NR 5 —SO 2 —, —NR 5 —C(O)—NR 5 —, —C(O)—O— or —O—C(O)—; R 3 is hydroxyl, mercapto, halogen, amino, nitro, cyano, carbonyl, thiocarbonyl, alkyl, a carbocycle or a heterocycle, or two R 3 groups together form a carbocycle or a heterocycle; wherein said alkyl, carbocycles and heterocycles are optionally substituted with halogen, hydroxyl, mercapto, carboxyl, carbonyl, thiocarbonyl, amino, nitro, cyano, alkyl, haloalkyl, a carbocycle or a heterocycle and wherein one or more CH 2 groups of an alkyl group is optionally replaced with —O—, —S—, —S(O)—, —S(O) 2 —, —N(R 5 )—, —C(O)—, —C(O)—NR 5 —, —NR 5 —C(O)—, —SO 2 —NR 5 —, —NR 5 —SO 2 —, —NR 5 C(O)—NR 5 —, —C(O)—O— or —O—C(O)—; R 4 and R 4 ′ are independently H, hydroxyl, halogen, amino, carbonyl, thiocarbonyl, alkyl, a carbocycle or a heterocycle, or R 4 and R 4′ together form a carbocycle or heterocycle, wherein said alkyl, carbocycles and heterocycles are optionally substituted with halogen, hydroxyl, carboxyl, amino, alkyl, a carbocycle or a heterocycle and wherein one or more CH 2 groups of an alkyl group is optionally replaced with —O—, —S—, —S(O)—, —S(O) 2 —, —N(R 5 )—, —C(O)—, —C(O)—NR 5 —, —NR 5 —C(O)—, —SO 2 —NR 5 —, —NR 5 —SO 2 —, —NR 5 —C(O)—NR 5 —, —C(O)—O— or —O—C(O)—; R 5 is H, alkyl, a carbocycle or a heterocycle wherein one or more CH 2 or CH groups of said alkyl is optionally replaced with —O—, —S—, —S(O)—, —S(O) 2 —, —NH—, or —C(O)—; and said alkyl, carbocycle and heterocycle is optionally substituted with hydroxyl, alkoxy, acyl, halogen, mercapto, carbonyl, carboxyl, acyl, halo-substituted alkyl, amino, cyano nitro, amidino, guanidino an optionally substituted carbocycle or an optionally substituted heterocycle; m is 0 to 10; or a salt thereof.