Patent ID: 8101566

Claim:
A method of suppressing angiogenesis in a mammal comprising the step of administering to the mammal an angiostatically effective amount of a pharmaceutical composition comprising an isolated antiangiogenic truncated tryptophanyl-tRNA synthetase (TrpRS) polypeptide or an isolated nucleic acid that comprises a polynucleotide sequence that encodes the truncated TrpRS polypeptide; wherein the truncated TrpRS polypeptide comprises residues 94-471 of SEQ ID NO: 10, residues 71-471 of SEQ ID NO: 10, residues 48-471 of SEQ ID NO: 10, or a polypeptide of approximately 47 kD molecular weight produced by cleavage of the polypeptide of SEQ ID NO: 10 with polymorphonuclear leucocyte elastase; and wherein the truncated TrpRS polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO:10.