Patent ID: 7718691

Claim:
A compound, or enantiomer, stereoisomer, rotamer, tautomer, diastereomer and racemate of said compound, or a pharmaceutically acceptable salt or ester of said compound, said compound of the general structure shown in Formula I: wherein: R 1 is OR 8 , NR 9 R 10 , or CHR 9 R 10 , wherein R 8 , R 9 and R 10 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, aryl-, heteroalkyl-, cycloalkyl-, and arylalkyl-; or R 10 is R 14 , wherein R 14 is selected from the group consisting of: A and M are connected to each other (in other words, A-E-L-M taken together) such that the moiety: shown above in Formula I forms either a three, four, six, seven or eight-membered cycloalkyl; E is C(H)or C(R); L is C(H) or C(R); R, R 2 , and R 3 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, cycloalkyl-, heteroalkyl-, aryl-, (cycloalkyl)alkyl-, and aryl-alkyl-; Y is: wherein Y 30 and Y 31 are selected from G is NH or O; and R 15 , R 16 , R 17 , R 18 , R 19 , T 1 , T 2 , T 3 and T 4 can be the same or different, each being independently selected from the group consisting of H, alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, cycloalkyl, aryl, and arylalkyl, or alternately, R 17 and R 18 are connected to each other to form a three to eight-membered cycloalkyl; wherein each of said alkyl, aryl, or cycloalkyl or can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of: hydroxy, alkoxy, aryloxy, thio, alkylthio arylthio, amino, amido, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, sulfonamido, alkyl, aryl, heteroaryl, alkylsulfonamido, arylsulfonamido, keto, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halo, cyano, and nitro.