Patent ID: 8497289

Claim:
A compound having a structure represented by a formula: wherein R 1 is optionally substituted organic residue comprising 1 to 12 carbon atoms; wherein each of R 2a and R 2b is independently selected from hydrogen, halogen, OR, nitrile, nitro, SR, N(R) 2 , and optionally substituted organic residue having 1 to 6 carbons; wherein each R is independently hydrogen or optionally substituted C 1-6 aliphatic, or two R groups on the same nitrogen are taken together with the nitrogen to form a 4-8 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein R 3a and R 3b are two substituents oriented in a syn geometry relative to each other, wherein R 3a and R 3b are independently selected from hydrogen and optionally substituted organic residue having 1 to 6 carbons; wherein R 4 is selected from hydrogen, halogen, OR, cyano, nitro, SR, N(R) 2 , and optionally substituted organic residue having 1 to 12 carbons; wherein R 5 is two substituents and each is independently selected from hydrogen, halogen, OR, cyano, nitro, SR, N(R) 2 , and optionally substituted organic residue comprising 1 to 6 carbons; wherein R 6 is five substituents and each is independently selected from hydrogen, halogen, OR, cyano, nitro SR, N(R) 2 , and optionally substituted organic residue comprising from 1 to 6 carbon atoms; wherein the carbon at position “a” has a stereochemistry of R or S or a mixture thereof; or a pharmaceutically acceptable salt thereof.