Patent ID: 8518968

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof; wherein Ar 1 is where G is O, N, or S, and R 6 is nitro, cyano, —PO 4 , —CHO, or —COOH; and Ar 1 is optionally substituted with one or more substituents independently chosen from cyano, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, mono- and di-(C 1 -C 2 )alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; X 1 is CR 1 or N; X 2 is CR 2 or N; X 3 is CR 3 or N; X 4 is CR 4 or N; wherein is not unsubstituted or substituted phenyl, unsubstituted pyridyl, or unsubstituted pyridazine, or 2-methylbenzo[d]thiazole, and no more than 2 of X 1 -X 4 are N; R 1 to R 4 are independently chosen from hydrogen, halogen, hydroxyl, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 )alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; and One of the following three conditions may be present: R 1 and R 2 may be taken together to form a 6-membered carbocyclic ring, or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms independently chosen from N, O, and S, which carbocyclic or heterocyclic R 1 /R 2 ring is substituted with 0 or 1 or more substituents independently chosen from halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 )alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 2 and R 3 may be taken together to form a 6-membered carbocyclic ring, or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms independently chosen from N, O, and S, which carbocyclic or heterocyclic R 2 /R 3 ring is substituted with 0 or 1 or more substituents independently chosen from halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 )alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 3 and R 4 may be taken together to form a 6-membered carbocyclic ring, or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms independently chosen from N, O, and S, which carbocyclic or heterocyclic R 3 /R 4 ring is substituted with 0 or 1 or more substituents independently chosen from halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 )alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; and R 5 is hydrogen, halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- or di-(C 1 -C 4 )alkylamino, C 1 -C 2 haloalkyl, or C 1 -C 2 haloalkoxy.