Patent ID: 7973059

Claim:
A compound of formula I, or a pharmaceutically acceptable salt, or an optical isomer thereof, wherein: R 1 , R 2 , and R 3 are independently selected from the group consisting of 1) hydrogen, 2) halogen, 3) NO 2 , 4) CN, 5) CR 4= C(R 4 ) 2 , 6) C≡CR 4 , 7) (CR 5 2 ) n OR 4 , 8) (CR 5 2 ) n N(R 4 )2, 9) (CR 5 2 ) n C(O)R 4 , 10) (CR 5 2 ) n C(O)OR 4 , 11) (CR 5 2 ) n R 4 , 12) (CR 5 2 ) n S(O) m R 4 , 13) (CR 5 2 ) n S(O) m N(R 4 )2, 14) OS(O) m R 4 , 15) N(R 4 )C(O)R 4 , 16) N(R 4 )S(O) m R 4 , 17) (CR 5 2 ) n N(R 6 )R 4 , 18) (CR 5 2 ) n N(R 4 )(CR 5 2 ) n C(O)N(R 4 )2, 19) (CR 5 2 ) n N(R 4 )(CR 5 2 ) n C(O)OR 4 , 20) N(R 4 )(CR 5 2 ) n R 4 , 21) N(R 4 )(CR 5 2 ) n N(R 4 )2, 22) (CR 5 2 ) n C(O)N(R 4 )2, 23) (CR 5 2 ) n C(O)NH(CR 5 2 ) n R 4 , 24) (CR 5 2 ) n C(O)NHC(R 4 ) 2 (CR 5 2 ) n N(R 4 )2, 25) C(O)NH(CR 5 2 )(CR 5 3 ), 26) S(O) m R 5 , and 27) N(R 4 )(R 5 ); R 4 , in each instance in which it appears, is independently selected from the group consisting of 1) hydrogen, 2) C 1 -C 6 alkyl, 3) C 3 -C 10 cycloalkyl, 4) aryl, 5) CF 3 , 6) C 2 -C 6 alkenyl, and 7) C 2 -C 6 alkynyl, or in the case where R 4 is attached to a nitrogen atom that is disubstituted with R 4 , each R 4 is independently selected from C 1 -C 6 alkyl, and the nitrogen atom together with each R 4 form a ring; R 5 , in each instance in which it appears, is independently selected from the group consisting of 1) hydrogen, 2) C 1 -C 6 alkyl, 3) halogen, 4) aryl, 5) C 3 -C 10 cycloalkyl, 6) OR 4 , and 7) CH 2 OR 4 ; m is independently selected from 0, 1 and 2; and n is independently selected from 0, 1, 2, 3, 4, 5 and 6.