Patent ID: 8394819

Claim:
A compound of the formula I: or a pharmaceutically acceptable salt thereof, wherein: represents either Y 1 is selected from optionally substituted aryl and —C(R 2 )(R 3 )(R 4 ); Y 2 is selected from H and —C 1-6 alkyl; Z is selected from H and —C 1-6 alkyl; R 1a and R 1b are independently selected from H, halogen, —OC 1-6 alkyl, —O-haloC 1-6 alkyl, —C 1-6 alkyl, haloC 1-6 alkyl, optionally substituted aryl and —(C 1-3 alkylene)-optionally substituted aryl; R 2 is selected from H; —C 1-6 alkyl optionally substituted with halogen, —OH or —NHSO 2 CH 3 ; —OH; —OC 1-6 alkyl; —S(O) n C 1-6 alkyl; —CN; optionally substituted aryl; optionally substituted —O-aryl and optionally substituted heteroaryl, wherein n is 0, 1 or 2; R 3 is selected from H, —C 1-6 alkyl, C 1-6 haloalkyl, optionally substituted aryl and optionally substituted heteroaryl; and R 4 is selected from H, —C 1-6 alkyl, C 1-6 haloalkyl, optionally substituted aryl and optionally substituted heteroaryl; or R 3 , R 4 and the carbon atom to which they are attached together form —C 3-6 cycloalkyl, fluorenyl or —C 3-6 heterocyclyl having a ring heteroatom selected from —N(R a )—, —O— and —S—; or R 3 , R 4 together represent C 1-6 alkylidene; R a is H, C 1-6 alkyl or —C(O)C 1-6 alkyl; and the optional substituent for aryl and heteroaryl is 1 to 4 groups independently selected from halogen, —C 1-3 alkoxy, —C 1-3 haloalkyl, hydroxy-C 1-3 alkyl, —S(O)n-C 1-3 alkyl, amino, and mono- and di-(C 1-3 alkyl)amino.