Patent ID: 8633224

Claim:
A compound having the structure or a pharmaceutically acceptable salt, ester or salt of an ester thereof; wherein g is 0, 1, 2 or 3; X 2 is C(═O), CR A R B , or —SO 2 —; wherein each occurrence of R A and R B is independently hydrogen, or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; R 2 is hydrogen, —(C═O)R C or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; wherein each occurrence of R C is independently hydrogen, OH, OR D , or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; wherein R D is an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; R 5 , R 6 and R 7 are each independently hydrogen, —(C═O)R E or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, wherein each occurrence of R E is independently hydrogen, OH, OR F , or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, or wherein any two R 5 , R 6 and R 7 groups, taken together, form an alicyclic, heteroalicyclic, alicyclic(aryl), heteroalicyclic(aryl), alicyclic(heteroaryl) or heteroalicyclic(heteroaryl) moiety, or an aryl or heteroaryl moiety; wherein R F is an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; R 8a , R 9a and R 10a are each independently hydrogen, or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; R L1 and R L2 are each independently hydrogen or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; and Q is NR Q′ R Q″ ; wherein R Q′ and R Q″ , taken together with the nitrogen atom to which they are attached, form a heteroalicyclic moiety.