Patent ID: 8450350

Claim:
A compound of the formula (I): or a pharmaceutically acceptable form thereof; wherein: R A is selected from C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, 5-14 membered heteroaryl, and hydrogen; X is selected from —CN, —C(═O)N(R X2 ) 2 , and —CO 2 R X1 R B is selected from C 6-14 aryl, 5-14 membered heteroaryl, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, and 3-14 membered heterocyclyl; R C is selected from hydrogen, —OH, —OR C1 , —ON(R C2 ) 2 , —N(R C2 ) 2 , —C(═O)R C1 , —CHO, —CO 2 R C1 , —C(═O)N(R C2 ) 2 , —C(═NR C2 )OR C1 , —C(═NR C2 )N(R C2 ) 2 , —SO 2 R C1 , —S(═O)R C1 , —Si(R C1 ) 3 , C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl; or R B and R C together with the nitrogen (N) atom to which each is attached are joined to form a 5-14 membered carbocyclyl, heterocyclyl, aryl or heteroaryl ring; each R C1 and R X1 is, independently, selected from C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl; each R C2 is, independently, selected from hydrogen, —OH, —OR C1 , —N(R C3 ) 2 , —CN, —C(═O)R C1 , —C(═O)N(R C3 ) 2 , —CO 2 R C1 , —SO 2 R C1 , —C(═NR C3 )OR C1 , —C(═NR C3 )N(R C3 ) 2 , —SO 2 N(R C3 ) 2 , —SO 2 R C3 , —SO 2 OR C3 , —SOR C1 , —C(═S)N(R C3 ) 2 , —C(═O)SR C3 , —C(═S)SR C3 , —P(═O) 2 R C1 , —P(═O)(R C1 ) 2 , —P(═O) 2 N(R C3 ) 2 , —P(═O)(NR C3 ) 2 , C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl; each R X2 is, independently, selected from hydrogen, —OH, —OR X1 , —N(R X3 ) 2 , —CN, —C(═O)R X1 , —C(═O)N(R X3 ) 2 , —CO 2 R X1 , —SO 2 R X1 , —C(═NR X3 )OR X1 , —C(═NR X3 )N(R X3 ) 2 , —SO 2 N(R X3 ) 2 , —SO 2 R X3 , —SO 2 OR X3 , —SOR X1 , —C(═S)N(R X3 ) 2 , —C(═O)SR X3 , —C(═S)SR X3 , —P(═O) 2 R X1 , —P(═O)(R X1 ) 2 , —P(═O) 2 N(R X3 ) 2 , —P(═O)(NR X3 ) 2 , C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl; and each R C3 and R X3 is, independently, selected from hydrogen, C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl.