Patent ID: 6992079

Claim:
A method of treating a disorder characterized by abnormal cell proliferation, said method comprising the step of administering to a subject in need thereof a therapeutically effective amount of at least one compound having the formula (I): or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 1 is —R′, (C 6 -C 20 ) aryl or substituted (C 6 -C 20 ) aryl; R 2 is —R′, —OR′, —SR′, halogen or trihalomethyl; R 3 is —R′, —OR′, —SR′, halogen or trihalomethyl or, when taken together with R 4 , is (C 6 -C 20 ) aryleno; R 4 is —R′, —OR′, —SR′, halogen or trihalomethyl or, when taken together with R 3 , is (C 6 -C 20 ) aryleno; each of R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and R 14 is independently selected from the group consisting of —R′, halogen and trihalomethyl; R 15 is —R″, —C(O)R″, —C(S)R″, —C(O)OR″, —C(S)OR″, —C(O)SR″, —C(S)SR″, —C(O)N(R″) 2 , —C(S)N(R″) 2 , —C(O)C(O)R″, —C(S)C(O)R″, —C(O)C(S)R″, —C(S)C(S)R″, —C(O)C(O)OR″, —C(S)C(O)OR″, —C(O)C(S)OR″, —C(O)C(O)SR″, —C(S)C(S)OR″, —C(S)C(O)SR″, —C(O)C(S)SR″, —C(S)C(S)SR″, —C(O)C(O)N(R″) 2 , —C(S)C(O)N(R″) 2 , —C(O)C(S)N(R″) 2 or —C(S)C(S)N(R″) 2 ; each R′ is independently selected from the group consisting of —H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl and (C 2 -C 6 ) alkynyl; each R″ is independently selected from the group consisting of —H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 6 -C 20 ) aryl, (C 6 -C 20 ) substituted aryl, (C 6 -C 26 ) alkaryl and substituted (C 6 -C 26 ) alkaryl; and the aryl and alkaryl substituents are each independently selected from the group consisting of —CN, —OR′, —SR′, —NO 2 , —NR′R′, halogen, (C 1 -C 6 )alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl and trihalomethyl, wherein said disorder is a solid tumor or a hematological neoplasm or an angiogenic disorder or a vasculogenic disorder.