Patent ID: 7132427

Claim:
A compound having the structure: or pharmaceutically acceptable derivative thereof; wherein R A is hydrogen, halogen, or an aliphatic or heteroaliphatic moiety; R B is an aryl, heteroaryl, -(alkyl)aryl, -(alkyl)heteroaryl, -(heteroalkyl)aryl, or -(heteroalkyl)heteroaryl moiety, optionally substituted with one or more occurrences of R 3 ; AK is an aliphatic moiety; each occurrence of PCM is independently a phosphorus-containing moiety having one of the following structures: wherein each occurrence of R 1 is independently hydrogen, alkyl or aryl; each occurrence of R 3 is independently hydrogen; halogen; —CN; NO 2 ; N 3 ; R′ 1 ; —GR′ 1 ; —CO(Y′R′ 1 ); —NR 1 (Y′R′ 1 ); S(O) 2 (Y′R′ 1 ); where Y′ is independently —O—, —S—, —NR′ 1 —, —C(O)—, —COO—, or S(O) 2 , wherein R′ 1 is independently a substituted or unsubstituted aliphatic, heteroaliphatic, aryl, -(alkyl)aryl, -(alkyl)heteroaryl, -(heteroalkyl)aryl, or -(heteroalkyl)heteroaryl moiety, and each occurrence of G is independently absent, or is —O—, —S—, —NR′ 1 —, S(O) 2 , or (M) x ; wherein each occurrence of x is independently an integer from 0–6, and each occurrence of M is independently a substituted or unsubstituted C 1 -alkylene moiety, and any two adjacent M moieties may be connected with a single, double or triple bond, as valency permits; each occurrence of R 4 is independently alkyl or aryl; each occurrence of R 6 is independently hydrogen, or an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or a prodrug moiety; t is an integer from 1–3; each occurrence of Z 1 and Z 2 is independently —O—, —S—, NR K , or C(O), wherein each occurrence of R J and R K is independently hydrogen, C(O)R L , COOR L , S(O) 2 R L , —NR L R M , or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, or alkylheteroaryl moiety, wherein each occurrence of R L and R M is independently hydrogen, or an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety; wherein in each of the foregoing groups each aliphatic, heteroaliphatic, alkyl and heteroalkyl moiety may be branched or unbranched, cyclic or acyclic and substituted or unsubstituted, and may contain one or more electronically unsaturated bonds, and each aryl and heteroaryl moiety may be substituted or unsubstituted.