Patent ID: 7498342

Claim:
A compound having the structure or a salt or isomer thereof, wherein: R 2 is X 1 is selected from the group consisting of lower alkylene, substituted lower alkylene, —C(O)—, —CH 2 —C(O)—, —C(O)CH 2 —, —C(S)—, —CH 2 —C(S)—, —C(S)CH 2 —, —O—, —S—, —S(O 2 )— and —NR a , wherein R a is selected from the group consisting of hydrogen, lower alkyl and lower alkyl substituted with fluoro, hydroxyl, alkoxy, thiol, thioalkoxy, or amino, provided, however, that hydroxyl, alkoxy, thiol, thioalkyoxy or amino are not substituted at the carbon bound to the nitrogen of —NR a ; X 3 is selected from the group consisting of wherein R b at each occurrence is independently selected from the group consisting of hydrogen, lower alkyl and lower alkyl substituted with fluoro, hydroxyl, alkoxy, thiol, thioalkoxy, or amino, provided, however, that hydroxyl, alkoxy, thiol, thioalkyoxy or amino are not substituted at the carbon bound to the nitrogen of NR b ; and R c is selected from the group consisting of alkylene and substituted alkylene; C 2 is selected group consisting of aryl and heteroaryl; R d is selected from the group consisting of halogen, lower alkyl, substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted alkylthio, optionally substituted alkenyl, optionally substituted alkyknyl, optionally substituted amine, optionally substituted amido, carboxyl, hydroxyl, optionally substituted aryl, aryloxy, optionally substituted heterocycle, optionally substituted heteroaryl, nitro, cyano, thiol, and sulfonylamino; and m is in the range 0-2.