Patent ID: 7384915

Claim:
A method of treating a patient selected from the group consisting of patients predicted to be at risk of developing Type 1 diabetes and patients suffering from Type I diabetes, said method comprising the repeated administration of a dose of a measured amount of a chimeric fusion protein in a pharmaceutically effective carrier to said patient, said chimeric fusion protein comprising an amino terminus and a carboxyl terminus, wherein the protein comprises insulin chain B, the first 7 amino acid residues of insulin chain C, and individual peptide moieties consisting of at least two glutamate decarboxylase (GAD) 65 peptides capable of eliciting a human T cell response, wherein the insulin chain B, insulin chain C, and the at least two human GAD 65 peptides are covalently linked and the chimeric fusion protein is capable of eliciting a human T cell response to insulin chain B and to each of the at least two GAD 65 peptides.