Patent ID: 7612081

Claim:
Compounds with general formula (I) in which m is the number 0 or 1; Z and Z′ are an integer ranging from 0 to 2 when they are different or are an integer ranging from 1 to 2 when they are the same; Y and Y′, which can be the same or different, are (CH 2 ) n1 ; (CH 2 ) n2 —CH[NR VII (CH 2 ) n4 —NHR I ]—(CH 2 ) n3 ; CH 2 —CH[CH 2 —CH 2 ] 2 — or (CH 2 ) n2 —N[(CH 2 ) n4 —NHR IV ]—(CH 2 ) n3 ; Y″ is selected from the group consisting of H; cycloalkyl C 3 -C 7 ; (CH 2 ) n5 —N[CH 2 —CH 2 ] 2 N—(CH 2 )n 6 NHR V ; (CH 2 )n 7 CH[CH 2 —CH 2 ] 2 NR V ; X is O, or is a simple bond; n-n7, which can be the same or different, are an integer ranging from 0 to 5; R I , R II , R III , R IV , and R V , which can be the same or different, are a protective group for the nitrogen to which they are bound, said protective group is selected from the group consisting of: CO 2 R VI ; CO 2 CH 2 Ar; CO 2 -(9-fluorenylmethyl); (CH 2 ) n5 —NH CO 2 R VI ; (CH 2 ) n5 —NHCO 2 CH 2 Ar; (CH 2 ) n5 —NHCO 2 -(9-fluorenylmethyl); R VI is a straight or branched (C 1 -C 6 )alkyl; R VII is H or R I -R V ; Ar is a C 6 -C 12 aromatic residue, such as phenyl, optionally substituted with one or more groups selected from: halogen, hydroxy, C 1 -C 5 alkyl, C 1 -C 5 alkoxy, phenyl, cyano, nitro, —NR VIII R IX , where R VIII and R IX , which can be the same or different, are hydrogen, straight or branched (C 1 -C 5 ) alkyl, or Ar is a heterocyclic group, said heterocyclic group containing at least one heteroatom selected from a nitrogen atom, optionally substituted with a (C 1 -C 5 ) alkyl group, and/or oxygen and/or sulphur; said heterocycle can be substituted with one or more groups selected from halogen, hydroxy, C 1 -C 5 alkyl, C 1 -C 5 alkoxy, phenyl, cyano, nitro, —NR VIII R IX , where R VIII and R IX , which can be the same or different, are hydrogen, straight or branched (C 1 -C 5 ) alkyl, the N1-oxides, racemic mixtures, their individual enantiomers, their individual diastereoisomers, the E and Z forms, their mixtures, and pharmaceutically acceptable salts.