Patent ID: 7989467

Claim:
A method of treating a disease related to a pre-messenger RNA splicing process within a cell wherein said disease is Frasier syndrome, frontotemporal dementia related to chromosome 17 (a form of Parkinson's), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, a certain neuropathology related to Tau protein mutation, Alzheimer's disease, amyotrophy that influences the SMN (survival motor neuron) gene, depression related to disturbances in serotonin splicing and AIDS, comprising administering to a patient in need thereof a medicine comprising a compound of benzo-indole or pyrido-indole derivative corresponding to the following formula I: or a pharmaceutically acceptable salt, isomer and/or mixture thereof, wherein X represents N or N + R4 anhydro base, and ring A, which is in position b corresponds to wherein R1 represents an atom of hydrogen or halogen or a —C═N—OH or —O—C(═O) (CH 3 ) or —C≡N group, or a —N—R6R7 group, wherein R6 and R7 represent independently of one another a hydrogen atom, a saturated or unsaturated ring having C6, optionally containing an atom of nitrogen and possibly substituted by one or more alkyl groups at C1 to C3, or a linear, branched and/or unsaturated alkyl group having C1 to C13 in which one or more atoms of carbon is optionally substituted by an atom of nitrogen, said alkyl group being optionally substituted by one or more —OH and/or ═O groups and/or by a group selected from the following compounds: said group being optionally substituted by an alkyl group at C1 to C3 which itself is possibly substituted by an amino group, or a —NH—R8 group wherein R8 represents an alkyl-N—R9R10 group, wherein the alkyl group of said alkyl-N—R9R10 group represents a linear or branched group having C1 to C13 optionally unsaturated and/or substituted by one or more alkyl groups at C1 to C3 and/or hydroxyl groups, and R9 and R10 represent independently of one another a hydrogen atom or an alkyl group having C1 to C4 optionally substituted by one or more hydroxyl and/or oxo groups, R2 represents a hydrogen atom, a methyl group or a —NH—(CH 2 ) 3 —N(CH 3 ) 2 group, R3 represents a hydrogen atom, a halogen atom or a methyl, amino or methoxymethyl group, or said —NH—R8 group, R4 represents a hydrogen atom, a hydroxyl or alkyl group having C1-C6 or a methoxy group optionally substituted by a phenyl group, R5 represents a hydrogen atom or a methyl or methoxymethyl group when X represents N or R5 is absent when X represents N + R4 anhydro base, R11 and R12 represent independently of one another a hydrogen atom or an alkyl group having C1-C3 and R13 represents a hydrogen atom or a methyl group.