Patent ID: 8178520

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1 or 2; R 1 is CO 2 R 5 , CONR 5 SO 2 R 5 , CONR 5 SO 2 N(R 5 ) 2 or tetrazolyl; R a and R b , together with the carbon atom to which they are attached, form a C 3-6 cycloalkyl group, optionally substituted by R 2 ; R 2 is C 1-6 alkyl or C 2-6 alkenyl, wherein said alkyl or alkenyl is optionally substituted with 1 to 3 halo; R 3 is C 1-6 alkyl, (CH 2 ) 0-3 C 3-8 cycloalkyl, (CH 2 ) 0-3 aryl or (CH 2 ) 0-3 Het, optionally substituted by halo, OR 5 , SR 5 , N(R 5 ) 2 , C 1-6 alkyl, NO 2 , CN, CF 3 , NR 5 SO 2 R 5 , SO 2 N(R 5 ) 2 , NHCO 2 R 5 , NHCOR 5 , NHCONHR 5 , CO 2 R 5 , C(O)R 5 or CON(R 5 ) 2 ; R 4 is hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, CN, NO 2 , C 3-8 cycloalkyl, N(R 5 ) 2 , aryl or heteroaryl, optionally substituted by 1 to 8 halo or C 1-4 -alkyl; each R 5 is independently hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl; each W is independently halo, OR 5 , C 1-6 alkyl, CN, NO 2 , CF 3 , CO 2 R 5 , CON(R 5 ) 2 , COR 5 , NR 5 C(O)R 5 , aryl or heteroaryl; Z is a bond or C═O; M is C 2-12 alkylene or C 2-12 alkenylene, optionally substituted by C 1-6 alkyl, (CH 2 ) 0-3 C 3-8 cycloalkyl or (CH 2 ) 0-3 aryl, and optionally containing one O or S atom; ring A is a 8- to 10-membered fused heterobicyclic ring system containing 1 to 4 heteroatoms selected from N, O and S; and ring B is a C-linked 5- or 6-membered heteroaromatic ring containing 1 to 4 heteroatoms selected from N, O and S.