Patent ID: 7425340

Claim:
A non-occlusive composition for topical or transdermal administration of an anticholinergic or antispasmodic agent, the composition comprising: at least one anticholinergic or antispasmodic agent of at least one of oxybutynin, flavoxate, imipramine, propantheline, phenylpropanolamine, darifenacin, duloxetine, tolterodine tartrate, trospium, or solifenacin succinate or a pharmaceutically acceptable salt thereof in an amount between about 0.1 to 20% by weight of the formulation; a compound selected from the group consisting of urea, 1,3-dimethylurea, 1,1-diethylurea, 1-acetyl-1-phenylurea, isopropylideneurea, allophanic acid, hydantoic acid, allophanoyl, pyrrolidone carboxylic acid, biuret, thiobiuret, dithiobiuret, triuret and 2-(3-methylureido)-1-naphthoic acid in an amount of between about 1 to 20% by weight of the formulation for enhancing permeation of the anticholinergic or antispasmodic agent; and a carrier suitable for transdermal or topical administration and comprising the combination of an alcohol, a polyalcohol, and either a monoalkyl ether of diethylene glycol or a tetraglycol furol present in the carrier in a combined amount effective with the amount of urea-containing compound to enhance permeation of the anticholinergic or antispasmodic agent through dermal or mucosal surfaces; wherein the alcohol is present in an amount of about 30 to 70% by weight of the formulation, the polyalcohol is present in an amount of about 1 to 15% by weight of the formulation, and the monoalkyl ether of diethylene glycol or tetraglycol furol is present in an amount between about 1 to 15% by weight of the formulation.