Patent ID: 8722714

Claim:
A compound of formula (I): or pharmaceutically acceptable salts and solvates thereof; wherein: R 1 is selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )heteroalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-alkyl, heterocycloalkyl, heterocycloalkyl-(C 1 -C 6 )alkyl, heterocyclyl-alkyl, aryl, phenyl-(C 1 -C 6 )alkyl, imidazolyl-C 1 C 6 alkyl, pyrazolyl-(C 1 -C 6 )alkyl, oxazolyl-(C 1 -C 6 )alkyl, isoxazoyl-(C 1 -C 6 )alkyl, thiazolyl-(C 1 -C 6 )alkyl, isothiazolyl-(C 1 -C 6 )alkyl, furanyl-(C 1 -C 6 )alkyl, and thiophenyl-(C 1 -C 6 )alkyl; R 2 is (C 1 -C 8 )alkyl; R 3 is selected from the group consisting of —H, (C 1 -C 8 )alkyl, (C 1 -C 8 )heteroalkyl, heteroaryl-alkyl and aryl; R 4 is selected from the group consisting of —H, (C 1 -C 8 )alkyl, (C 1 -C 8 )heteroalkyl, arylalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-alkyl, X1S(O)R a , X 1 S(O) 2 R a , X 1 SO 2 NH 2 , X 1 S(O) 2 NHR a , —X 1 S(O) 2 N(R a ) 2 , —X 1 C(O)NH 2 , —X 1 C(O)NHR a , —X 1 C(O)N(R a ) 2 , —X 1 C(O)R a , —X 1 C(O)H, —X 1 C(═S)R a , —X 1 CO 2 H, —X 1 CO 2 R a , —X 1 P(O)(OR a ) 2 and an amino protecting group; wherein R a is (C 1 -C 8 )alkyl or aryl and each X 1 is independently a bond or an (C 1 -C 4 )alkylene; the wavy line denoted by indicates the carbon to which the wavy line is attached has a stereoconfiguration of R, S or a mixture thereof; optionally, R 1 and R 4 together with the atoms to which they are attached form a 5-membered heterocyclic ring containing 0-1 additional ring heteroatom selected from O or N; and wherein each of R 1 -R 4 groups is optionally substituted with from 1-3 R b substituents independently selected from the group consisting of halogen, —OH, —OR c , —OSi(R c ) 3 , —OC(O)O—R c , —OC(O)Rc, —OC(O)NHRc, —OC(O)N(R c ) 2 , —SH, —SR c , —S(O)R c , —S(O) 2 R c , —SO 2 NH 2 , —S(O) 2 NHR c , —S(O) 2 N(R c ) 2 , —NHS(O) 2 R c , —NR c S(O) 2 R c , —C(O)NH 2 , —C(O)NHR c , —C(O)N(R c ) 2 , —C(O)R c , —C(O)H, —C(═S)R c , —NHC(O)R c , —NR c C(O)R c , —NHC(O)NH 2 , —NR c C(O)NH 2 , —NR c C(O)NHR c , —NHC(O)NHR c , —NR c C(O)N(R c ) 2 , —NHC(O)N(R c ) 2 , —CO 2 H, —CO 2 R c , —NHCO 2 R c , —NR c CO 2 R c , —R c , —CN, —NO 2 , —NH 2 , —NHR c , —N(R c ) 2 , —NR c S(O)NH 2 , —NR c S(O) 2 NHR c , —NH 2 C(═NR c )NH 2 , —N═C(NH 2 )NH 2 , —C(═NR c )NH 2 , —N 3 , —NH—OH, —NR c —OH, —NR c —OR c , —N═C═O, —N═C═S, —Si(R c ) 3 , —NH—NHR c , —NHC(O)NHNH 2 , —P(O)(OR c ) 2 , —N═C═NR c and —S—CN, wherein each R c is independently an alkyl or aryl, wherein R c is optionally further substituted with from 1-3 substituents selected from the group consisting of halogen, —OH, —OR d , —SH, —SR d , —S(O) 2 R d , —SO 2 NH 2 , —C(O)NH 2 , —C(O)NHR d , —C(O)N(R d ) 2 , —C(O)R d , —C(O)H, —NHC(O)R d , —NR d C(O)R d , —CO 2 H, —CO 2 R d , —R d , —CN, —NO 2 , —NH 2 , —NHR d , —N(R d ) 2 , —NH—OH, —NR d —OH, —NR d —OR d , —N═C═O, —N═C═S, —NH—NHR d and —S—CN, wherein each R d is independently an (C 1 -C 6 )alkyl.