Patent ID: 7625549

Claim:
A method for observing if a condition of experiment changes a human anti-human antibody (HAHA) response in a transgenic mouse, said method comprising: providing a transgenic mouse that comprises a collection of human immunoglobulin genes in its genome and produces at least one human or humanized antibody from said human immunoglobulin genes, wherein the human or humanized antibody produced by the transgenic mouse binds to a foreign human antibody that is to be administered to the mouse, and wherein the collection of human immunoglobulin genes include genes that encode the human or humanized antibody; administering to said transgenic mouse said foreign human antibody under a condition of experiment, wherein said foreign human antibody was encoded by a human immunoglobulin gene that is not present in the genome of the transgenic mouse, wherein the foreign human antibody is capable of inducing a HAHA response, and wherein the HAHA response comprises the human or humanized antibody produced by the transgenic mouse binding to the foreign human antibody; and observing the mouse to determine if the condition of experiment changes the HAHA response that the foreign human antibody is capable of inducing in the transgenic mouse.