Patent ID: 7700563

Claim:
A heparin-binding growth factor (HBGF) analog of formula II: wherein: R 3 and R 5 are each independently NH 2 , an acyl group with a linear or branched C 1 to C 17 alkyl, aryl, heteroaryl, alkene, alkenyl or aralkyl chain including an N-terminus NH 2 , NH 3 + , NH group or a corresponding acylated derivative, or is an amino acid, a dipeptide or a tripeptide with an N-terminus NH 2 , NH 3 + , NH group or a corresponding acylated derivative; R 4 is —OH, NH 2 , NH—R 6 , or is an amino acid, a dipeptide or a tripeptide with a C-terminus —OH, NH 2 , or NH—R 6 ; R 6 is an aliphatic C 1 to C 17 chain; each X comprises a peptide chain that is selected from SEQ ID NO: 6, SEQ ID NO:10, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, and SEQ ID NO:19; J 1 and J 2 are each independently a trifunctional alpha amino acid residue, wherein each X is covalently bonded through a side chain of J 1 or J 2 ; Y is a linker comprising three amino hexanoic acid residues; Z is a non-signaling peptide that comprises a heparin binding domain, comprising SEQ ID NO: 2; n is 0 or 1, wherein when n=1 the synthetic peptide chains X are identical.