Patent ID: 7872128

Claim:
A compound of Formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein A is N or CH; Y is N or CR 3 ; each R 1 ′ , independently, is NR 9 R 9 , OR 9 , R 7 or R 9 and n is 0-3, wherein R 7 is H, C 1-8 -alkyl or C 3-8 -cycloalkyl, each of the C 1-8 -alkyl and C 3-8 -cycloalkyl optionally comprising 1-4 heteroatoms selected from N, O and S and optionally substituted with 1-3 substituents of NR 9 R 9 , OR 9 , SR 9 , C(O)R 9 , OC(O)R 9 , COOR 9 , C(O)NR 8 R 9 , C(O)NR 9 R 9 , NR 9 C(O)R 9 , NR 9 C(O)NR 8 R 9 , NR 9 C(O)NR 9 R 9 , NR 9 (COOR 9 ), S(O) 2 R 9 , S(O) 2 NR 9 R 9 , NR 9 S(O) 2 NR 8 R 9 , NR 9 S(O) 2 NR 9 R 9 , NR 9 S(O) 2 R 9 or R 9 ; each R 9 , independently, of NR 9 R 9 is H, acetyl or C 1-8 alkyl; and R 9 of OR 9 is H, haloalkyl, acetyl or C 1-8 alkyl; R 2 is H, halo, haloalkyl, NO 2 , C 1-8 alkyl, CN, OH, —O—C 1-8 alkyl, —O-haloalkyl, SH, —S—C 1-8 alkyl, NH 2 , —NH—C 1-8 alkyl, —N—(C 1-8 alkyl) 2 or —C(O)—C 1-8 alkyl; R 3 , at each occurrence, is H, halo, haloalkyl, NO 2 , C 1-8 alkyl, CN, OH, —O—C 1-8 alkyl, —O-haloalkyl, SH, —S—C 1-8 alkyl, NH 2 , —NH—C 1-8 alkyl, —N—(C 1-8 alkyl) 2 or —C(O)—C 1-8 alkyl; R 4 is H or C 1-8 alkyl; R 5 is a phenyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, pyridazinyl, thiophenyl, furyl, tetrahydrofuryl, pyrrolyl, pyrazolyl, quinolinyl, isoquinolinyl, quinazolinyl, isoquinazolinyl, phthalazinyl, thieno-pyrazolyl, imidazolyl, triazolyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, benzoxazolyl, benzothiazolyl, benzoxadiazolyl, indolyl, azaindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl or cyclohexyl, each of which is optionally substituted independently with 1-5 substituents of R 9 ; R 6 , at each occurrence, is H or C 1-8 alkyl; and each R 9 , independently, is H, halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, C 3-8 -cycloalkyl, C 1-8 alkylamino-, C 1-8 dialkylamino-, C 1-8 -alkoxyl, C 1-8 -thioalkoxyl or a saturated 6-membered monocyclic ring system formed of carbon atoms including 1-2 heteroatoms, said heteroatoms selected from O, N, or S, wherein each of the C 1-8 alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, C 3-8 -cycloalkyl, C 1-8 alkylamino-, C 1-8 dialkylamino-, C 1-8 -alkoxyl, C 1-8 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-3 substituents of C 1-4 -alkyl, methyl.