Patent ID: 8859591

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is a 5 membered heteroaryl group attached through either a carbon or nitrogen atom and which is optionally fused to a (C 4 -C 7 )cycloalkyl, phenyl or 6 membered heteroaryl; wherein the optionally fused 5 membered heteroaryl is optionally substituted with one to four substituents each independently selected from halo, —S(O) 2 —(C 1 -C 3 )alkyl, —S—(C 1 -C 3 )alkyl, hydroxy, —C(O)NR a R b , (C 3 -C 5 )cycloalkyl, cyano, phenyl which is optionally substituted with one to three halo, cyano, (C 1 -C 3 )alkyl or (C 1 -C 3 )alkoxy, 6 membered heteroaryl which is optionally substituted with one to three halo, cyano, (C 1 -C 3 )alkyl or (C 1 -C 3 )alkoxy, (C 1 -C 6 )alkyl optionally substituted with one to three fluoro, or (C 1 -C 6 )alkoxy optionally substituted with one to three fluoro; R a and R b are each independently H or (C 1 -C 3 )alkyl; R 2 is H or methyl; R 3 is tetrazolyl, —CH 2 -tetrazolyl, —(CH 2 ) 2 SO 3 H or —(CH 2 ) 2 CO 2 H, —CH 2 CHFCO 2 H or —CH 2 CHOHCO 2 H; A 1 , A 2 , A 3 and A 4 are each independently CR 4 or N, with the proviso that no more than two of A 1 , A 2 , A 3 and A 4 are N; R 4 at each occurrence is independently H, halo, cyano, (C 1 -C 3 )alkyl optionally substituted with one to three fluoro, or (C 1 -C 3 )alkoxy optionally substituted with one to three fluoro; L is —X—CH(R 5 )— or —CH(R 5 )—X—; X is CH 2 , 0 or NH; R 5 is (C 1 -C 6 )alkyl which is optionally substituted with one to three fluoro, hydroxy or methoxy; (C 3 -C 7 )cycloalkyl which is optionally substituted with one to two (C 1 -C 3 )alkyl which are optionally substituted with one to three fluoro and wherein one to two carbons of the (C 3 -C 7 )cycloalkyl can be replaced with a NH, N(C 1 -C 3 )alkyl, O or S; or (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl wherein the (C 3 -C 7 )cycloalkyl group of said (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl is optionally substituted with one to two (C 1 -C 3 )alkyl which are optionally substituted with one to three fluoro; B 1 , B 2 , B 3 and B 4 are each independently CR 6 or N, with the proviso that no more than two of B 1 , B 2 , B 3 and B 4 are N; and R 6 at each occurrence is independently H, halo, (C 1 -C 3 )alkyl optionally substituted with one to three fluoro, or (C 1 -C 3 )alkoxy optionally substituted with one to three fluoro.