Patent ID: 8404829

Claim:
A composition comprising: an RNA interference oligonucleotide inhibitor of PVT1 expression adapted for interacting with an RNA sequence at locus 8q24 of a human chromosome, and a pharmaceutically acceptable carrier, wherein the RNA interference inhibitor is capable of inhibiting PVT1 expression in an ovarian tumor cell having elevated PVT1 expression, wherein the RNA interference inhibitor comprises double-stranded siRNA oligonucleotide selected from the group consisting of SEQ ID NOS: 3 and 4, wherein the siRNA oligonucleotide is adapted to act at a sequence comprises an overlapping region of M34428 (SEQ ID NO:1) and a coding portion of XM — 372058 predicted coding region, base pairs 379 to 777 (SEQ ID NO:2), and wherein the siRNA oligonucleotide is 18-22 nucleotide bases in length.