Patent ID: 8231892

Claim:
A method of manufacturing a drug delivery system which comprises a segmented bioerodible implant, the method comprising: a) blending a first active agent with a first bioerodible polymer to form a first active agent polymer mixture; b) forming the first active agent polymer mixture into a rod shaped first implant segment having a longitudinal axis; c) blending a second active agent with a second bioerodible polymer to form a second active agent polymer mixture; d) forming the second active agent polymer mixture into a rod shaped second implant segment having a longitudinal axis; e) joining the segments at the ends thereof to permit separation from each other in situ into individual segments following implantation into a patient; wherein each of the segments is formed with at least one end having a cut surface that is at an angle to the longitudinal axis of less than 90° or one end having a beveled shaped surface; wherein at least one of the segments is formed by a double extrusion process; and wherein the segments erode at different rates in situ.