Patent ID: 7919623

Claim:
A compound of the formula: (wherein: R 1 is benzyl substituted with halogen; R 2 is hydrogen or lower alkyl; R 3 is optionally substituted alkyl (substituent: lower alkoxy, amino optionally substituted with lower alkyl, cyano, hydroxy, carboxy, or lower alkoxycarbonyl) or optionally substituted amino (substituent: lower alkyl); R 4 is optionally substituted carboxy (substituent: lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, optionally substituted amino lower alkyl, or an optionally substituted heterocyclic group), optionally substituted formylamino (substituent: lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, optionally substituted carbamoyl lower alkyl, optionally substituted lower alkoxy, optionally substituted amino, or optionally substituted carbamoyl), optionally substituted carbamoyl (substituent: lower alkyl, optionally substituted lower alkyl (substituent: hydroxy, lower alkoxy, optionally substituted amino, optionally substituted lower alkoxy, carbamoyl), or optionally substituted heterocyclic group lower alkyl), optionally substituted alkyl (substituent: hydroxy, halogen, an optionally substituted heterocyclic group, optionally substituted lower alkoxy, optionally substituted amino, optionally substituted carbamoyl, or optionally substituted carboxy), or optionally substituted alkenyl (substituent: hydroxy, halogen, an optionally substituted heterocyclic group, optionally substituted lower alkoxy, optionally substituted amino, optionally substituted carbamoyl, or optionally substituted carboxy)), or a pharmaceutically acceptable salt thereof (except for Compound (I-A) shown in Table 1 below) TABLE 1 (I-A) Compound No. R 2 R 3 R 4 20 H CH2CH2OMe H 27 H Me NHMs 28 H CH2CH2OMe NHMs 29 H i-Pr NHMs 85 Me Me H 86 H NHMe H 87 H NMe2 H 88 H OMe H 89 H H H 90 H Me H 91 H Et H 92 H i-Pr H 126 H CH2CH2NMe2 H 160 H CH2CH2OMe NHCOCH2OMe 161 H CH2CH2OMe NHCOCH2CH2CO2Et 162 H CH2CH2OMe NHCOCH2CO2Et 163 H CH2CH2OMe NHCOOEt 164 H CH2CH2OMe NHCOCH2CH2OMe 165 H CH2CH2OMe NHCO-thiophene 180 H CH2CH2OMe Ph-CH2OH 181 H NMe2 Ph-CH2OH (Me = methyl; i-Pr = isopropyl; Et = ethyl; Ms = methanesulfonyl; thiophene = thiophene; Ph = phenyl).