Patent ID: 7354389

Claim:
An analytic system for optical detection of a plurality of analytes that are bound to a biochip, the analytic system comprising: a platform functionally coupled to a confocal microscope detector and movable along an x-coordinate, a y-coordinate, and optionally a z-coordinate relative to the detector, wherein the platform is configured to receive a biochip; wherein the biochip has a plurality of registration markers and further has a plurality of analytes in predetermined positions relative to the registration markers; a first light source that is configured to illuminate the registration markers at a first angle relative to the z-coordinate to generate registration marker signals, and further comprising a second light source that is configured to sequentially illuminate at least two of the plurality of analytes at a second angle relative to the z-coordinate to generate at least two individual analyte signals, respectively; a computer configured to determine the position of the biochip with respect to a given x-coordinate value and a given y-coordinate value using the registration marker signals; and wherein the first and the second angles are different.