Patent ID: 7674577

Claim:
A method of detecting a genetically transmitted Carbohydrate Deficient Glycoprotein Syndrome (CDGS) in a mammal, the method comprising: a) providing a sample from a mammal, wherein the sample comprises a plurality of glycoconjugates; b) contacting the sample with at least one of: a first type of diagnostic reagent that binds to a first glycoconjugate that has an oligosaccharide determinant that: i) is present on glycoconjugates in a sample obtained from a mammal that has the CDGS, and ii) is absent or is present at reduced levels on glycoconjugates in a sample obtained from a mammal that does not have the CDGS wherein the first type of diagnostic reagent is a lectin; and a second type of diagnostic reagent that binds to a second glycoconjugate that has an oligosaccharide determinant that: i) is present on glycoconjugates in a sample obtained from a mammal that does not have the CDGS, and ii) is absent or is present at reduced levels on glycoconjugates in a sample obtained from a mammal that has the CDGS; and c) determining whether the diagnostic reagent binds to the glycoconjugates in the sample, wherein the binding of a diagnostic reagent of the first type, or the absence or reduced binding of a diagnostic reagent of the second type, is indicative of the presence of the CDGS in the mammal.