Patent ID: 7678792

Claim:
A compound of Formula (1): or a pharmaceutically acceptable salt thereof, wherein: Y is CR and Z is N; L is NR—C(O), C(O)NR, C(O)NRC(O)NR, NRC(O)NRC(O), NRC(S)NRCO, NRS(O) 0-2 or NRCONRS(O) 0-2 ; R 1 is halo, (CR 2 ) k NR 7 R 8 , (CR 2 ) k OR 9 , (CR 2 ) k SR 9 , aryl or heteroaryl; or R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein each of said C 1-6 alkyl and C 2-6 alkenyl is optionally substituted with ureayl, guanidyl, O(C 1-6 alkyl), or optionally substituted with C 3-7 cycloalkyl, phenyl, or heteroaryl, said phenyl is further optionally substituted with halo or an optionally halogenated C 1-6 alkyl; R 2 is (CR 2 ) 1-4 OR 9 , (CR 2 ) 1-4 NR 7 R 8 or aryl; or R 2 is C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein said C 1-6 alkyl is optionally substituted with phenyl, or heteroaryl; R 3 is halo or C 1-6 alkyl; R 4 is (CR 2 ) k R 6 , dihydroindenyl, C 1-6 alkyl or (CR 2 ) k OR 9 ; R 5 is H, halo or C 1-6 alkyl; R 6 is C 3-7 cycloalkyl, aryl, heterocyclic ring or heteroaryl, each of which is optionally substituted with halo, cyano, nitro, NR 7 R 8 , NRCOR 7 , (CR 2 ) p OR 9′ , (CR 2 ) p R 10 , or a C 1-6 alkyl optionally substituted with halo, hydroxyl, C 1-6 alkoxy or cyano; R 9′ is H, an optionally halogenated C 1-6 alkyl or (CR 2 ) p R 10 ; R 10 is C 3-7 cycloalkyl, aryl, 5-7 membered heterocyclic ring, or heteroaryl, each of which is optionally substituted with halo, cyano, nitro, NR 7 R 8 , NRCOR 7 , NRC(O)(CR 2 ) p NR 7 R 8 (7), NRCONR(CR 2 ) p NR 7 R 8 , OR 9 , or C 1-6 alkyl optionally substituted with hydroxyl; R 7 , R 8 and R 9 are independently H or C 1-6 alkyl; or R 7 and R 8 together with N in each NR 7 R 8 may form a 5-7 membered heterocyclic ring; each R is H or C 1-6 alkyl; k is 0-6; and n is 0-2; provided L is C(O)NRC(O)NR, NRC(O)NRC(O), NRC(S)NRCO or NRCONRS(O) 0-2 when R 1 is halo or (CR 2 ) k NR 7 R 8 and R 2 is C 1-6 alkyl.