Patent ID: 7544806

Claim:
A compound of formula 1 wherein R 1 is phenyl, benzoxazole, benzothiazole, or thiazolo[5,4-b]pyridine, each of which may be substituted with one, two or three R 2 ; R 2 are each independently C 1-6 -alkyl, C 1-6 -haloalkyl, halogen, or COOR 3 ; R 3 is H, or C 1-6 -alkyl; R 5 is C 2-6 -alkyl, C 1-6 -alkoxy, C 1-6 -acyloxy, C 1-6 -aralkyl, C 3-6 -cycloalkyl, (C 3-6 -cycloalkyl)-C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -thioalkyl, halogen, NO 2 or CN; R 6 are each independently C 1-6 -alkyl, C 1-6 -haloalkyl, or halogen; A is (C 3-6 cycloalkyl)-C 2-8 -alkylene or straight or branched chain C 2-8 -alkylene, each optionally substituted with halogen or OH; B is phenyl; D-E is CH—CH 2 — or C═CH—; X—W—V is N—C═CR 7 or C═C—NR 7 ; R 7 is H or C 1-6 -alkyl; Y is CF 2 , NR 4 , O, S(O) n ; i, j are each 1; n is 0, 1 or 2; m is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.