Patent ID: 7378444

Claim:
A compound of structural formula (I): or a pharmaceutically acceptable salt thereof, wherein: D-E and F-G are independently a cis or trans —C═C— or a —C≡C—; R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, —CH 2 R 4 , —CHR 4 R 4 and —CR 4 R 4 R 4 ; each R 4 is independently selected from —CN, —NO 2 and halogen; W is selected from —R 5 , —OR 5 , —SR 5 and —NR 5 R 5 ; each R 5 is independently selected from hydrogen, (C1-C6) alkyl optionally substituted with one or more of the same or different R groups, (C5-C14) aryl optionally substituted with one or more of the same or different R groups, phenyl optionally substituted with one or more of the same or different R groups, (C6-C16) arylalkyl optionally substituted with one or more of the same or different R groups, 5-14 membered heteroaryl optionally substituted with one or more of the same or different R groups, 6-16 membered heteroarylalkyl optionally substituted with one or more of the same or different R groups, and a detectable label; A is selected from (C1-C6) alkylene optionally substituted with 1, 2, 3, 4, 5 or 6 of the same or different halogen atoms, —(CH 2 ) m —O—CH 2 — and —(CH 2 ) m —S—CH 2 —, where m is an integer from 0 to 4; X is selected from —(CH2) n — and —(CH2) n —O—, where n is an integer from 0 to 6; Y is selected from hydrogen, (C1-C6) alkyl optionally substituted with one or more of the same or different R groups, (C5-C14) aryl optionally substituted with one or more of the same or different R groups, phenyl, optionally substituted with one or more of the same or different R groups, (C6-C16) arylalkyl optionally substituted with one or more of the same or different R groups, 5-14 membered heteroaryl optionally substituted with one or more of the same or different R groups, 6-16 membered heteroarylalkyl optionally substituted with one or more of the same or different R groups and a detectable label molecule; each R is independently selected from an electronegative group, ═O, —OR a , (C1-C3) haloalkyloxy, ═S, —SR a , ═NR 3 , ═NONR a , —NR c R c , halogen, —CF 3 , —CN, —NC, —OCN, —SCN, —NO, —NO 2 , ═N 2 , —N 3 , —S(O)R a , —S(O) 2 R a , —S(O)2OR a , —S(O) 2 NR c R c , —OS(O)R a , —OS(O) 2 R a , —OS(O) 2 OR a , —OS(O) 2 NR c R c , —C(O)R a , —C(O)OR a , —C(O)NR c R c , —C(NH)NR c R c , —OC(O)R a , —OC(O)OR a , —OC(O)NR c R c , —OC(NH)NR c R c , —NHC(O)R a , —NHC(O)OR a , —NHC(O)NR c R c and —NHC(NH)NR c R c ; each R a is independently selected from hydrogen and (C1-C4) alkyl; and each R c is independently an R a or, alternatively, R c R c taken together with the nitrogen atom to which it is bonded forms a 5 or 6 membered ring, with the proviso that when X-Y is —CH 2 CH 3 , then at least one of R 1 , R 2 or R 3 is other than hydrogen.