Patent ID: 8541565

Claim:
At least a first polynucleotide and a second polynucleotide which together encode a fusion protein, wherein said first and second polynucleotides are a part of the same nucleic acid molecule or a different nucleic acid molecule, and wherein said first polynucleotide encodes a polypeptide comprising (Ia) and (II), below, and said second polynucleotide encodes a polypeptide comprising (Ib), below, or said first polynucleotide encodes a polypeptide comprising (Ia), below, and said second polynucleotide encodes a polypeptide comprising (Ib) and (II), below, wherein (Ia) is a heavy chain of an anti-CD14 antibody or its CD14 binding fragment, wherein said antibody or the fragment has an antigen binding activity and an inhibitory activity for LPS-induced IL-6 production in a TLR expressing cell, and wherein (Ib) is a light chain of an anti-CD14 antibody or its CD14 binding fragment, wherein said antibody or the fragment has an antigen binding activity and an inhibitory activity for LPS-induced IL-6 production in a TLR expressing cell, and wherein (II) is an inhibitor for a protease recited in 1), 2) or 3) below; 1) a polypeptide consisting of any one of amino acid sequences selected from the group consisting of a human UTI domain 2 (hereinafter referred to “UTI-D2”) represented by from 474th to 543rd amino acid residues of SEQ ID NO 10 and a mutant of human UTI domain 2 with 3 amino acid substitutions (R11S/Q19K/Y46D) (hereinafter referred to “UTI-D2(3)”) represented by from 474th to 543rd amino acid residues of SEQ ID NO 12, 2) a mutant of UTI-D2, wherein the mutant has one or more mutations, and wherein the one or more mutations are selected from the group consisting of: a deletion of the 474th amino acid of SEQ ID NO: 10, a deletion of the 475th amino acid of SEQ ID NO: 10, a substitution of the 484th amino acid of SEQ ID NO: 10, a substitution of the 492nd amino acid of SEQ ID NO: 10, and a substitution of the 519th amino acid of SEQ ID NO: 10 to the amino acid sequence recited in 1) above, wherein said mutant has an anticoagulant action, or an inhibitory action for a blood coagulation factor, 3) a polypeptide consisting of any one of amino acid sequences selected from the group consisting of the amino acid sequences of the mutant UTI domain 2 of SEQ ID NOS: 34, 36, 42, 43, 46, 47, 48, 49, 62 and 63.