Patent ID: 7994315

Claim:
A production method of an optically active morpholine compound represented by the formula 10, which comprises the following steps: wherein R is an aryl optionally having substituent(s) or a heteroaryl optionally having substituent(s), R 1 is a C 1 -C 6 alkyl, an aralkyl optionally having substituent(s) or a C 2 -C 6 alkenyl, R 2 is a C 1 -C 6 alkyl, a C 1 -C 6 haloalkyl, an aryl optionally having substituent(s) or a benzyl optionally having substituent(s), and X 2 is a halogen, step 1) reacting a compound of the formula 5 with an activated chloroacetic acid or bromoacetic acid in a solvent to give a compound of the formula 6, step 2) reacting the compound of the formula 6 with a base to give a compound of the formula 7, step 3) reacting the compound of the formula 7 with a reducing agent in a solvent to give a compound of the formula 8, step 4) reacting the compound of the formula 8 with a chloroformate to give a compound of the formula 9, and step 5) subjecting the compound of the formula 9 to hydrolysis to give the compound of the formula 10.