Patent ID: 8853228

Claim:
A compound of Formula V wherein R is selected from the group consisting of H, C 1 to C 5 alkyl, C 1 to C 3 alkoxy, and hydroxy; wherein R 1 , R 2 , R 3 , R 4 , independently are selected from the group consisting of hydrogen, C 1 to C 5 alkyl, and cycloalkyl; wherein A and B are each independently selected from the group consisting of hydrogen, C 1 to C 5 alkyl, hydroxy, and C 1 to C 6 alkoxy; wherein one of V and W is a methoxy group and the other is selected from the group consisting of hydrogen, C 1 to C 5 alkyl, and C 1 to C 6 alkoxy; wherein two of J, L, and M, are selected from the group consisting of hydrogen, C 1 to C 5 alkyl, halogen, hydroxy, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkoxyalkyl, carboxy, lower alkoxycarbonyl, cyano, nitro, aminocarbonyl, lower alkylsulfinyl, lower alkylcarbonylamino, lower alkylsulfonylamino, lower alkylthio, lower alkylsulfonyl, formyl, lower alkoxycarbonyl, dialkylsilyloxy, phenyl, phenoxy, arylalkoxy, and aryloxyalkoxy, wherein the phenyl, phenoxy, arylalkoxy, and aryloxyalkoxy substituents may themselves be optionally independently substituted one or more times with halogen, lower haloalkyl, lower alkyl, lower alkoxy, or lower alkylsulfonyl, wherein lower used in conjunction with any of the above groups is preferably C 1 to C 6 ; and wherein the other of J, L, and M is a substituent selected from the group consisting of piperidine, perhydropyrimidine, morpholine, pyridine, pyrimidine, indole, isoindole, quinoline, isoquinoline, oxazole, thiazole, and imidazole, wherein the piperidine, perhydropyrimidine, morpholine, pyridine, pyrimidine, indole, isoindole, quinoline, isoquinoline, oxazole, thiazole, or imidazole itself may be optionally substituted one or more times with C 1 to C 5 alkyl, halogen, hydroxy, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkoxyalkyl, carboxy, lower alkoxycarbonyl, cyano, nitro, aminocarbonyl, lower alkylsulfinyl, lower alkylcarbonylamino, lower alkylsulfonylamino, lower alkylthio, lower alkylsulfonyl, formyl, lower alkoxycarbonyl, dialkylsilyloxy, phenyl, phenoxy, arylalkoxy, or aryloxyalkoxy, wherein the phenyl, phenoxy, arylalkoxy, or aryloxyalkoxy substituents may themselves be optionally independently substituted one or more times with halogen, lower haloalkyl, lower alkyl, lower alkoxy, or lower alkylsulfonyl, wherein lower used in conjunction with any of the above groups is preferably C 1 to C 6 , or a pharmaceutically acceptable salt thereof.