Patent ID: 8188233

Claim:
An isolated PCSK9-specific antagonist antibody or antigen-binding fragment thereof which comprises: (a) a heavy chain variable region comprising CDR1, 2 and 3 domains; said CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 13; said CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 15; and said CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 17; and (b) a light chain variable region comprising CDR1, 2 and 3 domains; said CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 3; said CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 5, and said CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 7; wherein said PCSK9-specific antagonist antibody or fragment antagonizes PCSK9-mediated inhibition of cellular LDL uptake.