Patent ID: 8173652

Claim:
A compound of formula I, wherein R 1 is lower alkyl, optionally substituted by halogen, cyano, hydroxy, lower-alkoxy or halogen-lower-alkoxy, aryl, heteroaryl, cycloalkyl, or heterocyclyl; each of which is optionally substituted by halogen, cyano, hydroxy, lower alkyl, halogen-lower alkyl, cyano-lower alkyl, hydroxy-lower alkyl, lower alkyl-C(═O)OH, lower alkyl-C(═O)O-lower alkyl, lower alkyl-CO—NR 5 R 6 , lower alkyl-NR 5 R 6 , lower-alkoxy-lower alkyl, —CO-lower alkyl, —C(═O)OH, —C(═O)O-lower alkyl, —CONR 5 R 6 , —NR 5 R 6 , lower-alkoxy, halogen-lower-alkoxy, —SO 2 -lower alkyl, —SO 2 —NR 5 R 6 , cycloalkyl, phenyloxy or phenyl, R 2 is lower alkyl optionally substituted by halogen, cyano, hydroxy, lower-alkoxy or halogen-lower-alkoxy, R 3 is lower alkyl, optionally substituted by carboxy, halogen or hydroxyl; aryl, heteroaryl, cycloalkyl, or heterocyclyl; each of which is optionally substituted by carboxy, halogen, hydroxy or lower alkyl; or —NR 7 R 8 , R 4 is H or lower alkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached form a heterocyclic ring, R 5 is H or lower alkyl, R 6 is H or lower alkyl, R 7 is H or lower alkyl, R 8 is H or lower alkyl, Y is O or S, and X is CH 2 —O— or —CH═CH—, or a pharmaceutically active salt or ester thereof.