Patent ID: 8389011

Claim:
A method for forming a pharmaceutical composition, comprising the following steps: (a) forming a solution comprising a cholesteryl ester transfer protein inhibitor (CETPI), a concentration-enhancing polymer, and a solvent; (b) rapidly removing said solvent from said solution of step (a) to form a solid amorphous dispersion comprising said CETPI and said concentration-enhancing polymer; (c) forming particles from said dispersion of step (b); wherein said CETPI has a Clog P greater than 4, a solubility in aqueous solution in the absence of said concentration-enhancing polymer of less than 10 μg/mL at any pH of from 1 to 8, and wherein at least 60 wt % of said CETPI is non-crystalline, and wherein said dispersion has a glass transition temperature that is different than (i) the glass transition temperature of the amorphous form of said CETPI alone and (ii) the glass transition temperature of said concentration-enhancing polymer alone.