Patent ID: 8916591

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 , R 5 and R 6 are independently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxymethyl, methoxy, trifluoromethoxy, methylamino and dimethylamino; R 3 , and R 4 are independently selected from hydrogen, hydroxy, C 1 -C 3 alkyl, fluoro-(C 1 -C 3 )-alkyl, hydroxy-(C 1 -C 3 )-alkyl, C 1 -C 3 alkoxy, fluoro-(C 1 -C 3 )-alkoxy, hydroxy-(C 1 -C 3 )-alkoxy, —N(R 11 )—R 12 , -Alk-N(R 11 )—R 12 , —O-Alk-N(R 11 )—R 12 , —C(═O)OH, carboxy-(C 1 -C 3 )-alkyl, or —C(═O)—NH—R 13 ; Alk is a straight or branched chain divalent C 1 -C 6 alkylene radical; R 7 and R 8 are independently selected from hydrogen, hydroxy, or C 1 -C 3 alkoxy; X is a straight chain divalent C 1 -C 3 alkylene radical, optionally substituted on one or more carbons by R 9 and/or R 10 ; R 9 and R 10 are independently selected from methyl, hydroxy, or fluoro; R 11 is hydrogen, C 1 -C 3 alkyl, or fluoro-(C 1 -C 3 )-alkyl, and R 12 is C 1 -C 3 alkyl or hydroxy-(C 1 -C 6 )-alkyl, either of which may be optionally substituted on the alkyl portion by phenyl, C 1 -C 3 alkoxy-(C 1 -C 3 )-alkyl-, halo-(C 1 -C 4 )-alkyl, C 3 -C 6 cycloalkyl, methylsulfonyl-(C 1 -C 3 )-alkyl or —N(R 18 )—R 19 ; R 13 is hydrogen, C 1 -C 3 alkyl, fluoro-(C 1 -C 3 )-alkyl, or a radical of formula -Alk-N(R 14 )—R 15 ; R 14 and R 15 are independently selected from hydrogen, C 1 -C 3 alkyl, or fluoro-(C 1 -C 3 )-alkyl; W is selected from —C(═O)—N(—R 16 )— or —N(—R 17 )—C(═O)—; R 16 or R 17 is selected from hydrogen, C 1 -C 3 alkyl, or fluoro-(C 1 -C 3 )-alkyl; R 18 and R 19 are selected from hydrogen, C 1 -C 3 alkyl, or fluoro-(C 1 -C 3 )-alkyl; Y is hydrogen, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, or halo; and Q is selected from optionally substituted phenyl or optionally substituted cyclohexyl; wherein optionally substituted means optionally substituted by at least one substituent selected from the group consisting of (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, hydroxy(C 1 -C 6 )alkyl, mercapto, mercapto(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile (—CN), oxo, phenyl, —COOH, —COOR A , —COR A , —SO 2 R A , —CONH 2 , —SO 2 NH 2 , —CONHR A , —SO 2 NHR A , —CONR A R B , —SO 2 NR A R B , —NH 2 , —NHR A , —NR A R B , —OCONH 2 , —OCONHR A , —OCONR A R B , —NHCOR A , —NHCOOR A , —NR B COOR A , —NHSO 2 OR A , —NR B SO 2 OR A , —NHCONH 2 , —NR A CONH 2 , —NHCONHR B , —NR A CONHR B , —NHCONR A R B , and —NR A CONR A R B wherein R A and R B are independently a (C 1 -C 6 )alkyl group.