Patent ID: 8758725

Claim:
A compound of formula (IIIa) or (IIIb) or stereoisomer or atropisomer thereof: wherein T is a —CH 2 —; R 4 and R 5 are independently hydrogen, deuterium, hydroxy, oxygen, halogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 4 -C 10 cycloalkenyl, C 6 -C 12 aryl, C 6 -C 12 aralkyl, C 1 -C 12 heterocyclyl, C 1 -C 12 heteroaryl, —COR 1 , —(CH 2 ) m OR 1 , —CO 2 H, —CO 2 R 1 , —C(O)N(R 1 ) 2 , —C(O)NH(R 1 ), —C(O)NH 2 or an amino suitable protecting group, said C 1 -C 4 alkylenyl, C 2 -C 4 alkenylenyl, C 1 -C 4 heteroalkylenyl, C 2 -C 4 heteroalkenylenyl, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl C 3 -C 8 cycloalkyl, C 4 -C 10 cycloalkenyl, C 6 -C 12 aryl, C 6 -C 12 aralkyl, C 1 -C 12 heterocyclyl, and C 1 -C 12 heteroaryl being unsubstituted or substituted with at least one substituent selected from the group consisting of a halogen atom, hydroxy, carboxy, thiol, azide, nitro, C 1 -C 8 deuterated alkyl group comprising at least one deuterated atom, —COH, —COR 1 , —(CH 2 ) m OR 1 , —CO 2 H, —CO 2 R 1 , —C(O)N(R 1 ) 2 , —C(O)NH(R 1 ), —C(O)NH 2 , C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 4 -C 10 cycloalkenyl, C 6 -C 12 aryl, C 6 -C 12 aralkyl, C 1 -C 12 heterocyclyl and C 1 -C 12 heteroaryl; R 1 is a hydrogen atom, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 4 -C 10 cycloalkenyl, C 6 -C 12 aralkyl, or C 1 -C 12 heterocyclyl; each R 2 is independently a hydrogen atom, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 4 -C 10 cycloalkenyl, C 6 -C 12 aralkyl, or C 1 -C 12 heterocyclyl; p has a value of 4 so that ring A is a six-membered ring; R 6 is hydrogen; and R 7 is hydrogen; m is an integer having a value of 1 to 13, or a pharmaceutically acceptable salt thereof.