Patent ID: 8557979

Claim:
A process for preparing a β-methyl carbapenem analog comprising: (a) preparing or obtaining a carbapenem intermediate of the structure (A) wherein P is H, hydroxy, or hydroxyl protected by a hydroxyl protecting group; R is H or alkyl; R 1 is H or alkyl; P′ is a suitable carboxyl protecting group; and R′ is an alkyl or substituted alkyl; (b) coupling the compound of structure (A) with an amine, in the presence of Pd 2 (dba) 3 CHCl 3 (tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct) and a compound selected from 1,4-bis(diphenylphosphine)butane or triethylphosphate, to obtain a β-methyl carbapenem analog; and (c) optionally deprotecting the β-methyl carbapenem analog; wherein the amine is selected from the group consisting from: