Patent ID: 8829041

Claim:
A compound of formula: or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: one of R 1 and R 2 is a group of the formula -L 2 -R 6a -L 3 -R 6b ; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, cyano, and thioalkoxy, R 3 , R 3a , and R 3b are each independently selected from the group consisting of hydrogen, alkyl, trifluoroalkyl, trifluoroalkoxy, alkoxy, halogen, cyano, and thioalkoxy; R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the formula: R 7 , R 8 , R 9 , and R 10 at each occurrence are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, cycloalkyl, and alkyl; R 11 , R 12 , R 13 , and R 14 are each independently selected from the group consisting of hydrogen, hydroxyalkyl, alkyl, and fluoroalkyl; R 6a is a cyanophenyl or an unsubstituted or substituted ring selected from the group consisting of furyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, tetrazolyl, [1,2,3]thiadiazolyl, [1,2,3]oxadiazolyl, thiazolyl, thienyl, [1,2,3]triazinyl, [1,2,4]triazinyl, [1,3,5]triazinyl, [1,2,3]triazolyl, [1,2,4]triazolyl, azepanyl, azetidinyl, aziridinyl, azocanyl, dihydropyridazinyl, dihydropyridinyl, dihydropyrimidinyl, morpholinyl, pyrrolinyl, dihydrothiazolyl, dihydropyridinyl, thiomorpholinyl, dioxanyl, dithianyl, tetrahydrofuryl, dihydropyranyl, tetrahydropyranyl, [1,3]dioxolanyl, azetidin-2-onyl, azepan-2-onyl, isoindolin-1,3-dionyl, (Z)-1H-benzo[e][1,4]diazepin-5(4H)-onyl, pyridazin-3(2H)-onyl, pyridin-2(1H)-onyl, pyrimidin-2(1H)-onyl, pyrimidin-2,4(1H,3H)-dionyl, pyrrolidin-2-onyl, benzo [dl thiazol-2(3H)-onyl, pyridin-4(1H)-onyl, imidazolidin-2-onyl, 1H-imidazol-2(3H)onyl, tetrahydropyrimidin-2(1H)-onyl, [1,2,4]thiadiazolonyl, [1,2,5]thiadiazolonyl, [1,3,4]thiadiazinonyl, [1,2,4]oxadiazolonyl, [1,2,5]oxadiazolonyl, [1,3,4]oxadiazin-onyl, and 1H-benzo[d]imidazol-2(3H)-onyl; R 6b is hydrogen; Q is O or S; L is —[C(R 16 )(R 17 )] k ; L 2 is selected from the group consisting of a bond, alkylene, —O—, —C(═O)—, —S—, —NH—, —N(R 16 )C(═O)—, —C(═O)N(R 16 ), and —N(alkyl)-; L 3 is a bond; R 15 is selected from the group consisting of hydrogen, alkyl, acyl, alkoxycarbonyl, amido, and formyl; R 16 and R 17 at each occurrence are independently selected from the group consisting of hydrogen and alkyl; R x and R y at each occurrence are independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, alkoxy, alkylamino, fluoro, and dialkylamino; k is 1, 2 or 3; and m is 2.