Patent ID: 7034043

Claim:
A compound of the formula: R 3 -L-L′-R 1 wherein R 1 is piperidinyl N-substituted with —SO 2 —R 14 , where R 14 is 1) C 1-10 alkyl, 2) C 2-10 alkenyl, 3) C 2-10 alkynyl, 4) Cy, 5) Cy-C 1-10 alkyl, 6) Cy-C 2-10 alkenyl, or 7) Cy-C 2-10 alkynyl; L′ is in which Y 1 is —NR c —C(O)—, R 2 is 1) H, 2) C 1-10 alkyl, 3) C 2-10 alkenyl, 4) C 2-10 alkynyl, 5) Cy, 6) Cy-C 1-10 alkyl, 7) Cy-C 1-10 alkenyl, or 8) Cy-C 1-10 alkynyl; Y 2 is a bond; X is —C(O)OR c , L is in which Y 3 is C 1-5 alkylene, Y 4 is —C(O)—NR c —, R 3 is a moiety of the following formula: wherein: Y 5 is —CO—; R 4 is Z 5 -L c -Z 6 , where Z 5 is aryl, L c is —NH—C(O)—NH—, and Z 6 is aryl-C 1-10 alkyl; R 6 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl-fused cycloalkyl, cycloalkenyl, aryl, aralkyl, aryl-substituted alkenyl or alkynyl, cycloalkyl-substituted alkyl, cycloalkenyl-substituted cycloalkyl, biaryl, alkenoxy, alkynoxy, aralkoxy, aryl-substituted alkenoxy or alkynoxy, alkylamino, alkenylamino or alkynylamino, aryl-substituted alkylamino, aryl-substituted alkenylamino or alkynylamino, aryloxy, arylamino, heterocyclyl, heterocyclyl-substituted alkyl, heterocyclyl-substituted amino, carboxyalkyl substituted aralkyl, oxocarbocyclyl-fused aryl, or an amino acid side chain selected from the group consisting of arginine, asparagine, glutamine, S-methyl cysteine, methionine and corresponding sulfoxide and sulfone derivatives thereof, cyclohexylalanine, leucine, isoleucine, allo-isoleucine, tert-leucine, norleucine, phenylalanine, phenylglycine, tyrosine, tryptophan, proline, alanine, ornithine, histidine, glutamine, norvaline, valine, threonine, serine, beta-cyanoalanine, 2-aminobutyric acid and allothreonine; and R 5 is hydrogen, aryl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or aryl-substituted alkyl; and each R c , independently, is 1) H, 2) C 1-10 alkyl, 3) C 2-10 alkenyl, 4) C 2-10 alkynyl, 5) Cy, or 6) Cy-C 1-10 alkyl; wherein each of alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from R g ; R g is 1) halogen, 2) amino, 3) carboxy, 4) —COO—C 1-4 alkyl, 5) —P(O)(OH) 2 , 6) —P(O)(OH)(O—C 1-4 alkyl), 7) —P(O)(C 1-4 alkyl) 2 , 8) —P(O)(OH)(C 1-4 alkyl), 9) —P(O)(O—C 1-4 alkyl)(C 1-4 alkyl), 10) —SO 2 —C 1-4 alkyl, 11) —CO—NH 2 , 12) —CO—NH(C 1-4 alkyl), 13) —CO—N(C 1-4 alkyl)2, 14) —C 1-4 alkyl, 15) C 1-4 alkoxy, 16) aryl, 17) aryl-C 1-4 alkoxy, 18) hydroxy, 19) CF 3 , or 20) aryloxy; or a pharmaceutically acceptable salt thereof.