Patent ID: 8247532

Claim:
A process for preparing a salt of an optically enriched compound of Formula 1 wherein: R 1 is independently H, optionally substituted aliphatic, optionally substituted cycloaliphatic, optionally substituted arylaliphatic, optionally substituted heteroaliphatic or optionally substituted heteroarylaliphatic; R′ 1 is deuterium such that the deuterium enrichment is at least 50%; R′ 2 is —NHR 2 or —OE; R 2 is H, optionally substituted aliphatic, optionally substituted cycloaliphatic, optionally substituted arylaliphatic, optionally substituted heteroaliphatic or optionally substituted heteroarylaliphatic; and E is C 1-6 alkyl or benzyl; comprising the steps of: a) forming a salt of a racemic compound of Formula 1, and b) crystallizing said salt to give a compound of greater than 55% enantiomeric excess.