Patent ID: 8877457

Claim:
A myocardial toxicity examining device comprising: a transparent substrate; a cell population comprising a plurality of stably-pulsating myocardial cells arranged on the transparent substrate; a cell communication channel comprising a tandemly-arranged plurality of myocardial cells and fibroblast cells which conduct pulse from the cell population in cooperation with one of the cells of the cell population; a surrounding wall that is formed on the transparent substrate and surrounds the cell population and the cell communication channel such that the region surrounded by the wall is to be filled with a cell culture solution; means for feeding and draining the cell culture solution into and from the region surrounded by the walls; means for adding a drug that acts on the cells to the cell culture solution; a microelectrode provided on the transparent substrate and having thereon one of the cells of the cell population; a plurality of separate microelectrodes provided on the transparent substrate and having thereon some of the cells of the cell communication channel; a comparison electrode provided within the region surrounded by the walls; means for measuring and recording potentials of the cells on the microelectrodes by using readout lines connected to the respective microelectrodes and a readout line connected to the comparison electrode; and means for optically measuring a state of one of the cells arranged on the transparent substrate.