Patent ID: 7709469

Claim:
A compound having formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R 1 is hydrogen, alkyl, haloalkyl or —CN; R 2 is —N(H)—(CR u R v )—R 2a , —N(H)—R 2b or R 2b ; and R 3 is wherein R 2a is a group of formula (a) or (b); R 2b is a group of formula (c), (d) or (e) or R 2 is and R 3 is R 2b ; wherein R 2b is a group of formula (c), (d) or (e) Z 1 at each occurrence is independently C, C(H), C(H) 2 , O, S, S(O), S(O) 2 , N(H), N(alkyl) or N(acyl); Z 2 at each occurrence is independently C, C(H), or N; Z 3 at each occurrence is independently O, S, S(O), S(O) 2 , N(H), N(alkyl) or N(acyl); R 4 at each occurrence is independently halo, alkyl, —CN, —OR A , —SR A , —N(R A )(R B ) or haloalkyl; R 5 at each occurrence is independently alkyl, halo or haloalkyl; m at each occurrence is independently 0, 1, 2 or 3; n at each occurrence is independently 0, 1, 2 or 3; R a and R b at each occurrence are each independently halo, —CN, haloalkyl, haloalkoxy or alkyl; R c at each occurrence is independently hydrogen, halo, haloalkyl, alkoxy, haloalkoxy or alkyl; each of R u and R v at each occurrence is independently hydrogen, alkyl or haloalkyl; A 1 , A 2 , A 3 and A 4 are —C(R w ); or one or two of A 1 , A 2 , A 3 and A 4 are N, and the others are —C(R w ); or one of A 1 , A 2 , A 3 and A 4 is N + —O − and the others are —C(R w ); wherein R w at each occurrence is independently hydrogen, halo, alkyl, alkenyl, —OR A , —SR A , —N(R A )(R B ) or haloalkyl; A 5 is N, A 6 is O or S and A 7 is C(H) or C(alkyl), or A 5 is N, A 6 is C(H) or C(alkyl), and A 7 is O or S, or one of A 5 , A 6 and A 7 is S and the others are independently C(H) or C(alkyl); G is -W 2 or -L 2 -W 2 ; or G is hydrogen, alkyl, —Oalkyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —S(O)alkyl, —S(O) 2 alkyl, —S(O) 2 NH 2 , —S(O) 2 N(H)(alkyl), —S(O) 2 N(alkyl) 2 , —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , -W 2 or -L 2 -W 2 , when one of A 1 , A 2 , A 3 and A 4 is N; L 2 is N(H), N(alkyl), O, S, S(O), S(O) 2 , S(O) 2 N(H), SO 2 N(alkyl), N(H)S(O) 2 , N(alkyl)S(O) 2 , CON(H), CON(alkyl), N(H)CO, N(alkyl)CO); and W 2 at each occurrence is independently aryl, heteroaryl or heterocycle; and each W 2 is independently unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of ═O, halo, —CN, —NO 2 , alkyl, alkenyl, —OR A , —SR A , —S(O) 2 R A , —S(O) 2 N(R A )(R B ), —N(R A )(R B ), —C(O)R A , —C(O)N(R A )(R B ), —C(O)OR A , haloalkyl, -alkyl-OR A , -alkyl-SR A , -alkyl-S(O) 2 R A , -alkyl-S(O) 2 N(R A )(R B ), -alkyl-N(R A )(R B ), -alkyl-C(O)R A , -alkyl-C(O)N(R A )(R B ), and -alkyl-C(O)OR A ; R A at each occurrence is independently hydrogen, alkyl, alkenyl or haloalkyl; and R B at each occurrence is independently hydrogen, alkyl, or haloalkyl.