Patent ID: 8178526

Claim:
A compound of Formula I: wherein: n is 1; m is selected from 0, 1, 2 and 3; up to 3 groups of Ring A selected from —CR 1 ═, —CR 2 ═ and —CR 5 ═ are optionally replaced with —N═; R 1 , R 2 and R 5 are independently selected from hydrogen, hydroxy, halo, cyano, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkyl and cyano-substituted-C 1-6 alkyl; R 3 and R 4 , together with the carbon atoms to which R 3 and R 4 are attached, form a 5 to 6 member heterocycle fused to ring A containing up to 4 radicals selected from O, C(O), S(O) 2 , CR 11 R 12 and NH; wherein each R 11 and R 12 are independently selected from hydrogen, C 1-3 alkyl, and halo-substituted-C 1-3 alkyl; or R 11 and R 12 , together with the carbon to which they are both attached, forms C 3-7 cycloalkyl; R 6 and R 7 are independently selected from hydrogen, C 1-3 alkyl and halo-substituted-C 1-3 alkyl; or R 6 and R 7 , together with the carbon to which they are both attached, forms C 3-7 cycloalkyl; R 8 is selected from C 1-6 alkyl, C 2-6 alkenyl, halo-substituted-C 1-6 alkyl and hydroxy-substituted-C 1-6 alkyl; or two R 8 groups can combine to form an alkyl bridge; or when two R 8 groups are attached to the same carbon atom, they, together with the carbon to which they are both attached, form C 3-7 cycloalkyl; R 9 is selected from L 1 -C 6-10 aryl, L 1 -C 1-10 heteroaryl, C 1-6 alkyl, L 1 -C 3-12 cycloalkyl and L 1 -C 3-8 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R 9 can be optionally substituted with 1 to 3 radicals independently selected from halo, cyano, hydroxy, C 1-3 alkyl, halo-substituted-C 1-3 alkyl, cyano-substituted-C 1-3 alkyl, hydroxy-substituted-C 1-3 alkyl, —C(O)R 13 , —C(O)NR 13 R 14 ; wherein each R 13 and R 14 are independently selected from hydrogen and C 1-6 alkyl; L 1 is a bond, C 1-3 alkyl or halo-substituted-C 1-3 alkyl; Y is N or CR 10 ; R 10 is selected from hydrogen, C 1-6 alkyl, —NR 15 R 16 , —NR 15 C(O)R 16 and —C(O)NR 15 R 16 ; wherein each R 15 and R 16 are independently selected from hydrogen, C 1-6 alkyl, C 6-10 aryl, C 1-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl and heterocycloalkyl can be optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy and halo-substituted-C 1-6 alkoxy; and the pharmaceutically acceptable salts thereof.