Patent ID: 7432260

Claim:
A compound of formula Ib, or a pharmaceutically acceptable Salt thereof, wherein one of X 1 and X 2 is S, and the other of X 1 and X 2 is N; wherein: Z is NH, NHCO, NHSO 2 , NHCH 2 , CH 2 , CH 2 CH 2 , CH═CH, SO 2 , or SO; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently H, alkyl, aryl, aralkyl, halogeno, NO 2 , CN, OH, O-alkyl, O-aryl, NH 2 , NH-alkyl, NH-aryl, N-(alkyl) 2 , N-(aryl) 2 , N-(alkyl)(aryl), COOH, CONH 2 , CONH-alkyl, CONH-aryl, SO 3 H, SO 2 -alkyl, SO 2 -aryl, SO 2 NH 2 , CF 3 , CO-alkyl, CO-aryl, or R 11 , wherein alkyl, aryl, aralkyl groups may be further substituted with one or more groups selected from halogeno, NO 2 , OH, O-methyl, NH 2 , COOH, CONH 2 and CF 3 ; wherein at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 is R 11 ; each R 11 is: Y, wherein Y is an alicyclic group containing one or more of the functions —O—, NH 2 , —NH—, ═N—, and wherein Y is optionally substituted by one of more substituents selected from: SO 2 -alkyl; alkyl optionally substituted by one or more OH groups; CO-alkyl; aralkyl; COO-alkyl; and an ether group optionally substituted by one or more OH groups.