Patent ID: 8007814

Claim:
A therapeutic delivery system comprising: an extracted yeast cell wall defining an internal space and comprising about 6 to about 90 weight percent beta-glucan; a payload trapping molecule and a payload molecule selected from the group consisting of a nucleic acid, a peptide, a protein and a mixture thereof in an amount effective to supplement the function of a deficient lysosomal enzyme, wherein the deficient lysosomal enzyme results in an affected lysosomal function, and wherein the affected lysosomal function is a defective degradation of sphingolipid components related to a lysosomal storage disorder selected from the group consisting of Gaucher disease type 1, Gaucher disease type 2 and Gaucher disease type 3; wherein the payload molecule and the payload trapping molecule are soluble in the same solvent system; wherein the payload trapping molecule is contained within the internal space defined by the extracted yeast cell wall; and wherein the payload trapping molecule is present in an amount sufficient to facilitate retention of the payload molecule within the extracted yeast cell wall.