Patent ID: 8859590

Claim:
A compound of formula or a pharmaceutically acceptable salt, isomer, mixture of isomers, crystalline form, non crystalline form, hydrate, or solvate thereof, wherein R is optionally substituted aryl, X 1 is optionally substituted alkylene, and A is NR 1 , where R 1 is hydrogen or alkyl; or R is optionally substituted heteroaryl, X 1 is CH 2 , A is NR 1 , and R 1 is hydrogen or alkyl; or A is NR 1 , R is heteroaryl, and R 1 , X 1 and the attached nitrogen form a heterocycle; X 2 is C(O); Q 1 is 1,3-phenylene, which is optionally substituted at the 5-position with N-methylmethylsulfonylamido, alkyl, or heteroalkyl; X 3 is C(O); R 2 , R 3 , and R 4 are each hydrogen; R 5 is arylalkyl, which is optionally substituted; R 6a is C(O)NHR 10a , where R 10a is alkyl; and R 6b is alkyl.