Patent ID: 7741327

Claim:
A compound of formula (I): wherein: X is O, NH or N(lower alkyl); R 1 is -lower alkyl, -cycloalkyl, —CH 2 -cycloalkyl, -heterocycloalkyl, -aryl, unsubstituted or mono-, bi- or tri-substituted independently with alkenyl, hydroxy, —NH 2 , halogen, alkoxy, —CF 3 , —OCF 3 , —S(CH 3 ), —OCH 3 , —S(O 2 )CH 3 , —CH 2 -aryl, heteroaryl, cyano, alkoyl, —O-aryl, —O—CH 2 -aryl, —N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, —C(O)-heterocycloalkyl, unsubstituted lower alkyl, or lower alkyl mono- or bi-substituted with hydroxy, —CH 2 -aryl, -heteroaryl, unsubstituted or substituted with lower alkyl or halogen, -1-methyl-1H-indazol-4yl, -benzooxazol-4-yl -2-methyl-benzooxazol-4yl, -2,3-dihydro-benzo[1,4]dioxin-5-yl, -2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl -5,6,7,8-tetrahydro-naphthalen-1-yl, -naphthalen-1-yl or -isoquinolin; R 2 is -lower alkyl, -ether, -alkoxy, -cycloalkyl, -heterocycloalkyl, -aryl, unsubstituted or mono- or bi-substituted independently with halogen, or -heteroaryl having at least one ring heteroatom being either O or S; and R 3 is -lower alkyl-carbamoyl or -an unsubstituted or substituted heteroaryl connected by a ring carbon atom to the amine group shown, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom, said substituted heteroaryl being substituted at a position other than adjacent to said connecting carbon atom independently with halogen, ester, cyano, acid, cycloalkyl, aryl, 2-oxo-oxazolidin-5-ylmethyl, —N(lower alkyl) 2 , —CH 2 -dimethyl-[1,3]dioxolane, t-butyl-dimethyl-silanyloxy ethyl, unsubstituted —CH 2 -aryl, —CH 2 -aryl substituted with cyano or alkoxy, heterocycloalkyl, —CH 2 -heterocycloalkyl, -6-(CH 2 )-2,2-dimethyl-[1,3]dioxan-4-yl-acetic acid tert-butyl ester, unsubstituted lower alkyl, or lower alkyl mono-, bi- or tri-substituted independently with hydroxy, alkoxy, —N(lower alkyl) 2 , —NH 2 , ester, acid or carboxamide, or a pharmaceutically acceptable salt thereof.