Patent ID: 7863288

Claim:
A compound having the structure of Formula IIIm: or a pharmaceutically acceptable salt thereof, wherein: R 81 is selected from the group consisting of hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, â€”OH, â€”NH 2 , â€”CN, â€”NO 2 , â€”C(O)OH, â€”S(O) 2 NH 2 , â€”C(O)NH 2 , â€”C(S)NH 2 , â€”NHC(O)NH 2 , â€”NHC(S)NH 2 , â€”NHS(O) 2 NH 2 , â€”OR 68 , â€”SR 68 , â€”NR 69 R 68 , â€”C(O)R 68 , â€”C(S)R 68 , â€”C(O)OR 68 , â€”C(O)NR 69 R 68 , â€”C(S)NR 69 R 68 , â€”S(O) 2 NR 69 R 68 , â€”NR 69 C(O)R 68 , â€”NR 69 C(S)R 68 , â€”NR 69 S(O) 2 R 68 , â€”NR 69 C(O)NH 2 , â€”NR 69 C(O)NR 69 R 68 , â€”NR 69 C(S)NH 2 , â€”NR 69 C(S)NR 69 R 68 , â€”NR 69 S(O) 2 NH 2 , â€”NR 69 S(O) 2 NR 69 R 68 , â€”S(O)R 68 , and â€”S(O) 2 R 68 ; R 83 is selected from the group consisting of hydrogen, fluoro and chloro; R 112 is selected from the group consisting of optionally substituted C 2-6 alkyl, optionally substituted aryl, optionally substituted heteroaryl, and â€”NR 79 R 80 ; R 68 is selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R 68 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to N, S, O, S(O), S(O) 2 , C(O) or C(S) of â€”OR 68 , â€”SR 68 , â€”NR 69 R 68 , â€”C(O)R 68 , â€”C(S)R 68 , â€”C(O)OR 68 , â€”C(O)NR 69 R 68 , â€”C(S)NR 69 R 68 , â€”S(O) 2 NR 69 R 68 , â€”NR 69 C(O)R 68 , â€”NR 69 C(S)R 68 , â€”NR 69 S(O) 2 R 68 , â€”NR 69 C(O)NH 2 , â€”NR 69 C(O)NR 69 R 68 , â€”NR 69 C(S)NH 2 , â€”NR 69 C(S)NR 69 R 68 , â€”NR 69 S(O) 2 NH 2 , â€”NR 69 S(O) 2 NR 69 R 68 , â€”S(O)R 68 , or â€”S(O) 2 R 68 , optionally substituted lower alkynyl, provided, however, that when R 68 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to N, S, O, S(O), S(O) 2 , C(O) or C(S) of â€”OR 68 , â€”SR 68 , â€”NR 69 R 68 , â€”C(O)R 68 , â€”C(S)R 68 , â€”C(O)OR 68 , â€”C(O)NR 69 R 68 , â€”C(S)NR 69 R 68 , â€”S(O) 2 NR 69 R 68 , â€”NR 69 C(O)R 68 , â€”NR 69 C(S)R 68 , â€”NR 69 S(O) 2 R 68 , â€”NR 69 C(O)NH 2 , â€”NR 69 C(O)NR 69 R 68 , â€”NR 69 C(S)NH 2 , â€”NR 69 C(S)NR 69 R 68 , â€”NR 69 S(O) 2 NH 2 , â€”NR 69 S(O) 2 NR 69 R 68 , â€”S(O)R 68 , or â€”S(O) 2 R 68 , optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; R 69 is selected from the group consisting of hydrogen and optionally substituted lower alkyl; and R 79 and R 80 are independently hydrogen or optionally substituted lower alkyl, or R 79 and R 80 combine with the nitrogen to which they are attached to form optionally substituted 5-7 membered heterocycloalkyl.