Patent ID: 8921411

Claim:
Crystalline cabazitaxel, wherein the crystalline cabazitaxel is crystalline cabazitaxel designated as form III, characterized by: a solid state 13 C NMR spectrum with peaks at 139.8 127.8, 63.4, 25.4 and 23.5 ppm±0.2 ppm; a solid state 13 C NMR spectrum having chemical shift differences between said characteristic peaks at 139.8 127.8, 63.4, 25.4 and 23.5 ppm±0.2 ppm and a reference peak at 125.1±0.2 ppm of 14.8, 2.8, −61.7, −99.6 and −101.6 ppm±0.1 ppm, respectively; a solid state 13 C NMR spectrum substantially as depicted in any one of FIGS. 27-29 ; and combinations thereof; crystalline cabazitaxel designated as form II, characterized by: a solid state 13 C NMR spectrum with peaks at 174.3, 170.8, 166.5, 137.7, and 135.9 ppm±0.2 ppm; a solid state 13 C NMR spectrum having chemical shift differences between said characteristic peaks at 174.3, 170.8, 166.5, 137.7, and 135.9 ppm±0.2 ppm and a reference peak at 125.1±0.2 ppm of 49.2, 45.7, 41.4, 12.6 and 10.8 ppm±0.1 ppm, respectively; a solid state 13 C NMR spectrum substantially as depicted in any one of FIGS. 24-26 ; and combinations thereof; crystalline cabazitaxel form IV, characterized by: a solid state 13 C NMR spectrum with peaks at 128.4, 60.6, 19.0 and 13.6 ppm±0.2 ppm; a solid state 13 C NMR spectrum having chemical shift differences between said characteristic peaks at 128.4, 60.6, 19.0 and 13.6 ppm±0.2 ppm and a reference peak at 125.2±0.2 ppm of 3.2, −64.7, −106.2 and −111.6 ppm±0.1 ppm, respectively; a solid state 13 C NMR spectrum substantially as depicted in any one of FIGS. 30-32 ; and combinations thereof; or crystalline cabazitaxel form V, characterized by: a solid state 13 C NMR spectrum with peaks at 135.5, 70.4, 25.7 and 10.6 ppm±0.2 ppm; a solid state 13 C NMR spectrum having chemical shift differences between said characteristic peaks at 135.5, 70.4, 25.7 and 10.6 ppm±0.2 ppm and a reference peak at 125.1±0.2 ppm of 10.4, −54.7, −99.4 and −114.5 ppm±0.1 ppm, respectively; a solid state 13 C NMR pattern substantially as depicted in any one of FIGS. 33-35 ; and combinations thereof.