Patent ID: 8611981

Claim:
An MRI-CEST diagnostic system, comprising: an input module configured to provide an input map including a plurality of input elements each one for a corresponding selected location of a body-part, each input element being indicative of a spectrum of a magnetic response of the corresponding selected location including the magnetic response at an agent frequency of resonance of a CEST agent providing a magnetization transfer with a bulk substrate of the body-part, the agent frequency being at an agent offset of frequency from a bulk frequency of resonance of the bulk substrate, and at a reference frequency at the opposite of the agent offset from the bulk frequency, a calculation module configured to calculate an agent value and a reference value for each one of a set of the selected locations, the agent value being calculated according to multiple magnetic responses of the selected location in a non-punctual agent range of frequencies centered around the agent frequency, and the reference value being calculated according to multiple magnetic responses of the selected location in a non-punctual reference range of frequencies centered around the reference frequency, the reference range being symmetric to the agent range with respect to the bulk frequency, and a comparator module configured to calculate a parametric value for each one of the set of selected locations, the parametric value being calculated according to a comparison between the agent value and the reference value of the selected location.