Patent ID: 7879803

Claim:
A method for promoting hemostasis in a patient comprising administering to the patient an effective amount of a pharmaceutical preparation comprising a protease or a mixture of the protease and its proenzyme, wherein the protease a) activates blood clotting factor VII, b) is inhibited by the presence of aprotinin, c) is increased in its activity by the presence of at least one of the following: calcium ions, heparin, or heparin related substances, and d) in SDS-PAGE, on subsequent staining in the non-reduced state, comprises one or more bands in the molecular weight range from 50 to 75 kDa; and in SDS-PAGE, on subsequent staining in the reduced state, comprises a band at 40 to 55 kDa, one or more bands in the molecular weight range from 10 to 35 kDa, and a band, which corresponds to a proenzyme in the molecular weight range from 60 to 65 kDa.