Patent ID: 7109207

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt or solvate wherein X is —CH 2 —, —SO 2 —, carbonyl, —CHCH 3 or —C(CH 3 ) 2 —; Y is —(CR 2 R 3 ) p C(O)NH—, wherein p is a number from 1 to 3 and when p is more than 1, each (CR 2 R 3 ) can be the same or different; n is 0, such that no connecting bond exists between the two carbons adjacent to the nitrogen; r is 1; Ar is aryl or R 6 -substituted aryl; R 1 is hydrogen, methyl, ethyl, hydroxyethyl, cyclobutyl, cyclopentyl, cycloheptyl, -propyl, —SO 2 CH 3 , —SO 2 N(CH 3 ) 2 , —COCH 3 , —C(O)OC(CH 3 ) 3 , isopropyl, cyclopropylmethyl, R 2 and R 3 can be the same or different, each being independently hydrogen or -alkyl; or R 2 and R 3 can be joined together with the carbon to which they are attached to form a 3 to 7-membered ring; R 4 is aryl, R 7 -substituted aryl, or Y—R 4 is R 5 is -alkyl, aryl, aralkyl or heteroaryl; R 6 is 1 to 3 substituents, each R 6 can be the same or different and each is independently selected from the group consisting of —OH, -alkoxy, —OCF 3 , —CN, -alkyl, halogen, —NR 8 R 9 , —C(O)NR 8 R 9 , —NR 8 SO 2 R 5 , —SO 2 NR 8 R 9 , —SO 2 R 5 , —C(O)R 5 , —C(O)OR 5 , —CF 3 , —(CR 2 R 3 ) p″ NR 8 R 9 where p″ is a number from 1 to 3, —CHO, —C═NOR 8 , —NR 8 C(O)R 5 , —C(═NH)NR 8 R 9 , —C(═NCN)NR 8 R 9 , R 7 is hydrogen or 1 to 4 substituents, each R 7 can be the same or different and each is independently selected from the group consisting of —OH, -alkoxy, —OCF 3 , —CN, halogen, -nitro, —NR 8 R 9 , —NR 8 C(O)R 5 , —C(O)NR 8 R 9 , —NR 8 SO 2 R 5 , —SO 2 NR 8 R 9 , —SO 2 R 5 , —C(O)R 5 , —C(O)OR 8 , —CF 3 , —(CR 2 R 3 ) p″ NR 8 R 9 , —(CR 2 R 3 ) p″ NR 8 C(O)R 5 where p″ is a number from 1 to 3, —C(═NH)NR 8 R 9 , —C(═NCN)NR 8 R 9 and —CHO; or two adjacent R 7 groups can be joined together to form a methylenedioxy or ethylenedioxy group; R 8 is hydrogen or -alkyl; R 9 is hydrogen, -alkyl, aryl, substituted aryl, heteroaryl or aralkyl; and R 10 is —OH, -alkoxy, -cycloalkyl, -cycloalkylalkyl, —C(O)NR 8 R 9 , —NR 8 R 9 , —NR 8 SO 2 R 5 , —NR 8 C(O)R 5 , —NR 8 C(O)OR 5 , —NR 8 C(O)NR 8 R 9 , —C(O)OH or —C(O)OR 5 .