Patent ID: 8318674

Claim:
A method of locally treating non-healthy bone areas in a patient, comprising locally administering to a site in bone in need of treatment only one bioactive factor, wherein the bioactive factor is provided in a formulation comprising a composition capable of forming a matrix at the site, wherein the bioactive factor is selected from the group consisting of parathyroid hormone (PTH 1-84 ) or a parathyroid hormone (PTH) fragment selected from the group consisting of PTH 1-34 , PTH 1-31 and PTH 1-38 ; and a fusion peptide comprising (PTH 1-84 ) or a PTH fragment selected from the group consisting of PTH 1-34 , PTH 1-31 , and PTH 1-38 in a first domain and a covalently crosslinkable substrate domain in a second domain, and forming a supplemented matrix at the site, wherein the bioactive factor is capable of causing bone growth, wherein no other bioactive factor capable of causing bone growth is administered in the method, and wherein the site is a non-healthy bone area selected from the group consisting of bone areas affected by osteoporosis and bone cysts.