Patent ID: 6974865

Claim:
An oligomer of formula II: wherein: B x is a protected or unprotected heterocyclic base moiety; T 1 is an oligonucleotide, oligonucleoside, nucleoside, nucleotide, H or a hydroxyl protecting group; each X 1 and X 3 is, independently, O, S or NH; each X 2 is, independantly, OH, SH or NH 2 ; each L is, independantly, C(Y 1 )(Y 2 ) or O, provided that at least one L is C(Y 1 )(Y 2 ); each R 1 , independently, has one of formulas: wherein: Z 0 is, independently, O, S or NH; E 2 is N(Q 1 )(Q 2 ) or N═C(Q 1 )(Q 2 ); E 2 is C 1 -C 10 alkyl; each Q 1 and Q 2 is, independently, H, C 1 -C 10 alkyl, substituted alkyl, dialkylaminoalkyl, a nitrogen protecting group, a tethered or untethered conjugate group, a linker to a solid support; or Q 1 and Q 2 , together, are joined in a nitrogen protecting group or a ring structure that can include at least one additional heteroatom selected from N and O; each q 1 is, independently, from 1 to 10; q 2 is from 1 to 10; q 3 q 4 is zero, 1 or 2; q 5 each M 1 is, independently, H, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C(═NH)N(H)M 2 , C(═O)N(H)M 2 or OC(═O)N(H)M 2 ; M 2 is H or C 1 -C 8 alkyl; Z 1 , Z 2 and Z 3 comprise a ring system having from about 4 to about 7 carbon atoms or having from about 3 to about 6 carbon atoms and 1 or 2 heteroatoms wherein said heteroatoms are selected from oxygen, nitrogen and sulfur and wherein said ring system is aliphatic, unsaturated aliphatic, aromatic, or saturated or unsaturated heterocyclic; and Z 4 is OM 1 , SM 1 , or N(M 1 ) 2 ; Z 5 is alkyl or haloalkyl having 1 to about 10 carbon atoms, alkenyl having 2 to about 10 carbon atoms, alkynyl having 2 to about 10 carbon atoms, aryl having 6 to about 14 carbon atoms, N(Q 1 )(Q 2 ), OQ 1 , halo, SQ 1 or CN; p is 0 or an integer from 1 to 50; and each of Y 1 and Y 2 is, independently, H, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, cyano, carboxyl, ester or a cyclic moiety; wherein said substituted alkyl groups are substituted with one or more of alkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, alcohol, benzyl, phenyl, nitro, thiol, thioalkoxy, thioalkyl, trifluoromethyl, halo, nitrile, trifluoromethoxy or azido, and said substituted aryl groups are substituted with one or more of hydroxyl, alkoxy, alcohol, benzyl, phenyl, nitro, thiol, thioalkoxy, halogen, alkyl, aryl, alkenyl, or alkynyl.