Patent ID: 7820851

Claim:
A polyfluorinated compound useful as an imaging tracer suitable for administration to a subject or a sample, the compound of the formula: CF 3 (CF 2 ) n R 1 (I) where: R 1 is —C(O)OR 2 , -QR 3 , X, C 1 -C 30 alkyl, C 1 -C 30 haloalkyl, C 1 -C 30 alkoxyl, or C 1 -C 30 perhaloalkyl; R 2 is M Z+ , H, C 1 -C 12 alkyl, C 1 -C 12 alkyl, C 1 -C 12 perhalo alkyl, C 6 -C 30 aryl, C 6 -C 30 perhaloaryl, and a substituted form thereof where one or more protons or halogens is replaced with a plasma solubility enhancing moiety of or -QR 3 ; R 3 is H or F; Q is O or S; M Z+ is a cation that forms a net neutral compound with an anionic (CF 3 (CF 2 ) n C(O)O − ) Z and is an alkali metal cation, an alkali earth cation, a transition metal cation, ammonium, and aluminum cations; Z is an integer value of between 1 and 3 inclusive; X is a fluorine, chlorine, bromine or iodine atom; halo denotes a replacement of at least one and not all protons with X; perhalo denotes a replacement of all protons with X; and n is an integer value of between 1 and 30 inclusive, wherein the Formula (I) comprises at least two 18 F atoms.