Patent ID: 8309770

Claim:
A method for preparing compound (I) wherein, * denotes a [ 11 C], R 1 & R 2 = alkyl, aryl, alkoxide, or a halide; R 3 = H, CH 2 COOH, CH 2 CONHR′, or CH 2 CONR′R″ wherein R′ or R″ is alkyl, aryl, or a combination thereof, comprising the steps: flushing a solution of tris(dibenzylideneactone) palladium (0) and tri-o- tolylphosphine in anhydrous DMSO with nitrogen to form a mixture; then adding either an aryl halide, or aryl triflate to the mixture; thereafter filtering the mixture; next adding either aromatic or aliphatic boronic acid or an aliphatic organostannyl compound to form a compound mixture; then injecting the compound mixture into a microautoclave pre-charged with [11C] carbon monoxide to form a crude product; finally transferring the crude product to a vial at reduced pressure whereby the crude product is then diluted with water and thereafter the crude product is purified and identified by positron emission tomography.