Patent ID: 7723379

Claim:
An article of manufacture adapted for human or veterinary administration comprising (i) a compound selected from the group of polymeric compound of formula A n , and a pharmaceutically acceptable salt, derivative, or oxidation product thereof, in the amount effective to modulate nitric oxide (NO), and (ii) an additional NO-modulating agent, wherein A n is of the formula: wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(α)-OH, 3-(β)-OH, 3-(α)-O-sugar, or 3-(β)-O-sugar; bonding between adjacent monomers takes place at positions selected from the group consisting of 4,6 and 8; a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y and Z are selected from the group consisting of monomeric unit A, and hydrogen, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto is at position 4 and optionally Y=Z=hydrogen; and the sugar is optionally substituted with a phenolic moiety via an ester bond; and wherein the effective amount has a therapeutic or prophylactic effect when the product is administered for an effective period of time.