Patent ID: 8598347

Claim:
A method for manufacturing dipeptidyl peptidase-IV inhibitor represented by Chemical Formula 1 comprising: (Step 1) reacting a compound represented by Chemical Formula 2 and a compound represented by Chemical Formula 3 in the presence of isochloroformate, a base and a reaction solvent to prepare a compound represented by Chemical Formula 4; and (Step 2) removing an amine-protecting group of the compound represented by Chemical Formula 4 produced in the above Step 1 to prepare a compound represented by Chemical Formula 1, wherein PG is a protecting group; X is OR 1 , SR 1 or NR 1 R 2 , wherein R 1 and R 2 are each independently C 1 -C 5 lower alkyl, or, in the case of NR 1 R 2 , R 1 and R 2 may be 5-membered ring to 7-membered ring containing O; and HY is a free acid.