Patent ID: 8632776

Claim:
An isolated antibody or fragment thereof having high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers and having a combination of three variable heavy (VH) CDR sequences and three variable light (VL) CDR sequences selected from the following combinations: SEQ ID NOS: 22, 28, 35, 41, 47 and 50, SEQ ID NOS: 23, 29, 36, 42, 47 and 50, SEQ ID NOS: 24, 30, 37, 43, 48 and 51, SEQ ID NOS: 25, 31, 38, 44, 47 and 52, SEQ ID NOS: 26, 32, 39, 45, 47 and 53, SEQ ID NOS: 23, 33, 37, 43, 48 and 54, and SEQ ID NOS: 27, 34, 40, 46, 49 and 55.