Patent ID: 8168595

Claim:
An antithrombotic compound of the formula (I) oligosaccharide-spacer-A (I), wherein the oligosaccharide is a negatively charged pentasaccharide of the formula (II) wherein R 5 is OSO 3 − or (1-8C)alkoxy, the charge being compensated by positively charged counterions; the spacer is: A is the residue —CH[NH—SO 2 —R 1 ][CO—NR 2 —CH(4-benzamidine)-CO—NR 3 R 4 ], wherein R 1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which groups may optionally be substituted with one or more substituents selected from (1-8C)alkyl or (1-8C)alkoxy; and wherein R 2 and R 3 are independently H or (1-8C)alkyl; R 4 is (1-8C)alkyl or (3-8C)cycloalkyl; or R 3 and R 4 together with the nitrogen atom to which they are bonded are a nonaromatic (4-8) membered ring optionally containing another heteroatom, the ring optionally being substituted with (1-8C)alkyl or SO 2 -(1-8C)alkyl; or a pharmaceutically acceptable salt thereof; wherein the spacer of the compound of formula I comprises at least one covalent bond with a biotin residue or an analogue of the formula —(CH 2 ) 4 —NR—BT, where BT is the residue where R is H or (1-4C)alkyl.