Patent ID: 8133977

Claim:
A unit dose of a pharmaceutical composition comprising (i) a conjugate comprising one, two or three water-soluble polymers selected from the group consisting of a poly(alkylene glycol), a poly(oxyethylated polyol), a poly(olefinic alcohol), a poly(vinylpyrrolidone), a poly(hydroxyalkylmethacrylamide), a poly(hydroxyalkylmethacrylate), a poly(saccharide), a poly(α-hydroxy acid), a poly(vinyl alcohol), a polyphosphazene, a polyoxazoline, a poly(N-acryloylmorpholine), and combinations of any of the foregoing, covalently attached to a Factor VIII polypeptide selected from the group consisting of Factor VIII, Factor VIIIa, Factor VIII:C, Factor VIII:vWF and B-domain deleted Factor VIII, and (ii) a pharmaceutically acceptable excipient, wherein the Factor VIII polypeptide is present in an amount ranging from 0.001 mg to 100 mg.