Patent ID: 7919496

Claim:
A method of treating, but not preventing, dyslipidemia in a mammal, wherein the method comprises administering to the mammal a therapeutically effective amount of a compound of formula (Ia): x and y are each 1; G is —O— or —S—; L M are both —N═; W is —N(R 1 )C(O)—, —C(O)N(R 1 )—, —OC(O)N(R 1 )—, —N(R 1 )C(O)N(R 1 )—, —O—, —N(R 1 )—, —S(O) t — (where t is 0, 1 or 2), —N(R 1 )S(O) p — (where p is 1 or 2), —S(O) p N(R 1 )— (where p is 1 or 2), —C(O)—, —OS(O) 2 N(R 1 )—, —OC(O)—, —C(O)O—, or —N(R 1 )C(O)O—; V is —C(O)— or —C(S)—; each R 1 is independently selected from the group consisting of hydrogen, C 1 -C 12 alkyl, C 2 -C 12 hydroxyalkyl, C 4 -C 12 cycloalkylalkyl and C 7 -C 19 aralkyl; R 2 is selected from the group consisting of hydrogen, C 1 -C 12 alkyl optionally substituted with —OR 14 where R 14 is alkyl or cycloalkyl, C 2 -C 12 alkenyl, C 2 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl, C 2 -C 12 alkoxyalkyl, C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, aryl, and C 7 -C 19 aralkyl; R 3 is aryl optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, halo, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, —R 15 —OR 14 , —R 15 —OC(O)—R 14 , —R 15 —C(O)R 14 , —R 15 —C(O)OR 14 , and —R 15 —C(O)N(R 14 ) 2 , where each R 14 is independently hydrogen, alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl and each R 15 is independently a direct bond or a straight or branched alkylene chain, and where each R 14 and R 15 is unsubstituted; R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are each independently selected from hydrogen or C 1 -C 3 alkyl; and as a stereoisomer, enantiomer or tautomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof.