Patent ID: 8071772

Claim:
A compound of the formula I: wherein: B is a bicycloheterocycle selected from the group consisting of: where T, U, V, W, X and Y are each independently a carbon atom or a nitrogen atom, wherein no more than two of T, U, V and W, or no more than three of T, U, V, W, X and Y, are a nitrogen atom, where B is unsubstituted or substituted with 1 to 2 methyl, hydroxymethyl, trifluoromethyl, halogen, benzyl, benzyl alcohol, methoxy, CH 2 C(â•O)N(CH 3 ) 2 , CN, SO 2 N(CH 3 ) 2 , N,N-dimethylcarbamide or a 1-(benzylcarboxylate)piperidene-4-spiro group; A 1 , A 2 and A 3 are each independently selected from: (1) a bond, (2) â€”CR 13 R 14 â€”, wherein R 13 and R 14 are each hydrogen, and (3) â€”C(â•O)â€”; A 5 and A 6 are each â€”CH 2 â€”; both of A 4 and A 7 are absent; E 1 is â•Nâ€”, E 2 is â•Câ€”, E 3 is â•C(H)â€”, E 4 is absent, E 5 is â•C(H)â€”, or E 1 is â€”N(H)â€”, E 3 and E 4 are absent, E 2 is â•Câ€”, E 5 is â•Nâ€”; G 1 and G 2 are each â•C(R 4 )â€”; J is â•C(R 6a )â€”; K is â€”N(R 6b )â€”; R 4 is hydrogen; R 6a and R 6b and the atom(s) to which they are attached may be joined together to form a pyridyl ring, which is unsubstituted or a pharmaceutically acceptable salt thereof and individual enantiomers and diastereomers thereof.