Patent ID: 7045514

Claim:
A compound having the formula (I): wherein R 1 is, at each position, independently represented by hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, thiomethoxy, —NHA, —NA 2 , —NHC(═O)A, aminocarbonyl, —C(═O)NHA, —C(═O)NA 2 , halogen, hydroxy, —OA, cyano or aryl; A is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl or optionally substituted alkynyl; R 2 is represented by (i), (ii), (iii), or (iv) below: R 3 is independently at each position represented by —H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl or AOH; n is 2, 3 or 4; P is a heterocyclic ring; R 5 is —H, ═O, —OR 4 , —NR 4 2 ═NR 4 , —SR 4 or ═S; R 6 is —H or methyl; X is O, N, NH or S; Y is —C(═O)NH—, —C(═O)NA-, —C(═O)N(A)-, —NHC(═O)—, —C(═S)NH—, —CH 2 NH—, —C(═O)—, —C(═O)CH 2 —, —CH 2 C(═O)—, —C(═O)-piperazine-, —NAC(═O)—, —C(═S)N(A)-, CH 2 NA, NACH 2 or a 5-membered heterocyclic; R 7 is a monocyclic or bicyclic aromatic ring or a heterocycle optionally substituted by one or more substituents selected from R 8 -R 9 and R 10 ; wherein R 7 is connected to Y either by a single bond as tether, or by a ring fusion comprising a bond and two ring atoms shared by both rings; R 8 is —CH 2 —, —C(═O)—, —SO 2 —, —SO 2 NH—, —C(═O)NH—, —O—, —S—, —S(═O)— a single bond as tether from R 7 to R 9 , or a five-membered heterocyclic connected to R 7 by a ring fusion comprising a bond and two ring atoms shared by both rings, or a single bond as tether; R 9 is optionally substituted heterocycle, optionally substituted aryl, optionally substituted piperazinyl-R11, optionally substituted morpholinyl-R11, optionally substituted thiomorpholinyl, C(═O)A; R 10 is optionally substituted alkyl, optionally substituted cycloalkyl, hydroxy, aryl, cyano, halogen, —C(═O)NH 2 , methylthio, —NHA, —NA 2 , —NHC(═O)A, —C(═O)NHA, —C(═O)NA 2 , or —OA; R 11 is —H, alkyl, AOH, —SO 2 A, —SO 2 NH 2 , —SO 2 NHA, —SO 2 NA 2 , —SO 2 NHAR 9 , —C(═O)R 9 , -alkylR 9 , C(═O)A, C(═O)NH 2 , C(═O)NHA, C(═O)NA 2 or —C(═O)OA; or a pharmaceutically acceptable salt thereof; and represents a bond which may be either a single bond or a double bond, with the proviso that multiple double bonds are separated from one another by at least one single bond.