Patent ID: 8227498

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, including all tautomers and stereoisomers thereof wherein: R 1 represents alkyl; alkenyl, wherein the double bond is not adjacent to the nitrogen; carbocyclyl; —C 1-6 alkyl-carbocyclyl; heterocyclyl; —C 1-6 alkyl-heterocyclyl; aryl; heteroaryl; —C 1-6 alkylaryl; —C 1-6 alkylheteroaryl; -phenyl fused to carbocyclyl or -phenyl fused to heterocyclyl; in which any of the aforesaid carbocyclyl and heterocyclyl groups may optionally be substituted by one or more groups selected from methyl and oxo; and in which any of the aforesaid phenyl, aryl and heteroaryl groups may optionally be substituted by one or more substituents selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —C 1-6 thioalkyl, —SO 2 C 1-4 alkyl, C 1-6 alkoxy-, —O—C 3-8 cycloalkyl, C 3-8 cycloalkyl, —SO 2 C 3-8 cycloalkyl, C 3-6 alkenyloxy-, C 3-6 alkynyloxy-, —C(O)C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl), —C(O)OC 1-6 alkyl, —SOC 1-4 alkyl and —SOC 3-6 cycloalkyl; or R 1 represents phenyl substituted by phenyl, or phenyl substituted by an optionally substituted monocyclic heteroaryl group in which any of the aforesaid phenyl and monocyclic heteroaryl groups may optionally be substituted by one or more groups selected from C 1-4 alkyl, halogen and C 1-4 alkoxy; or R 1 represents phenyl substituted by benzyloxy- in which any of the aforesaid phenyl or benzyloxy groups may optionally be substituted on the ring by one or more groups selected from C 1-4 alkyl, halogen and C 1-4 alkoxy; X represents C or N; and A represents wherein Y represents a C 2-5 alkylene chain, which may optionally be substituted by one or two methyl groups or may optionally be substituted by two alkylene substituents at the same position wherein the two alkylene substituents are joined to each other to form a C 3-5 spiro-cycloalkyl group and R 2 , R 3 and R 4 independently represent H or C 1-2 alkyl, provided that R 2 and R 3 and R 4 do not all represent H; or A represents wherein Z represents a bond, —CH 2 —, —CH 2 —CH 2 —, —CH(Me)—, —CH(Me)—CH 2 — or —CH 2 —CH(Me)— and R 5 and R 6 independently represent H or C 1-2 alkyl and B represents H or methyl.