Patent ID: 8329682

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: X being selected from the group consisting of carbon and nitrogen; R 1 and R 2 each being independently selected from the group consisting of hydrogen and alkyl; R 3 being selected from the group consisting of alkyl, trifluoromethyl, aryl, aralkyl, and methyl, at least one of said alkyl, aryl, aralkyl, and methyl being optionally further substituted by halogen; R 4 being selected from the group consisting of alkyl, cycloalkyl, heterocyclo alkyl, aryl, heteroaryl, —(CH 2 ) n (OCH 2 CH 2 ) r R 11 , —[CH 2 CH(OH)] r CH 2 NR 9 R 10 and —(CH 2 ) n NR 9 R 10 , at least one said alkyl, cylcoalkyl, heterocyclo alkyl, aryl and heteroaryl is optionally further substituted by the group consisting of aryl, hydroxyl, amino, carboxamido, alkoxyl, aryloxy, aminoalkyl, hydroxyalkyl, heterocyclo alkyl, carboxyl, alkoxycarbonyl and —NR 9 R 10 ; when X is nitrogen, R 5 is absent, R 6 , R 7 , R 8 are each independently selected from the group consisting of hydrogen and halogen; when X is carbon, R 5 , R 6 , R 7 , R 8 are each independently selected from the group consisting of hydrogen, halogen, hydroxyalkyl, alkyl, cycloalkyl, heterocyclo alkyl, aryl, heteroaryl, hydroxyl, cyano, nitro, —OR 9 , —O[CH 2 CH 2 O] r R 11 , —NR 9 R 10 , —(CH 2 ) n CO 2 R 9 , —(CH 2 ) n CONR 9 R 10 , —COR 9 , —NR 9 COR 10 , —SO 2 R 9 and —NHCO 2 R 10 , at least one of said aryl, heteroaryl, cycloalkyl and heterocyclo alkyl is optionally further substituted by the group consisting of alkyl, alkoxyl and halogen; R 9 and R 10 each being independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heterocyclo alkyl and heteroaryl, at least one of said alkyl, cycloalkyl, aryl, heterocyclo alkyl and heteroaryl being optionally further substituted by the group consisting of alkyl, aryl, haloaryl, hydroxyl, amino, cyano, alkoxyl, aryloxy, hydroxyalkyl, heterocyclo alkyl, carboxyl, alkoxycarbonyl and —NR 9 R 10 ; R 9 and R 10 being taken together with the attached atom to form 4 to 8 membered hetero rings, wherein said 4 to 8 membered hetero rings contain at least one heteroatom selected from the group consisting of N, O and S, and said 4 to 8 membered rings being optionally further substituted by the group consisting of alkyl, halogen, aryl, heteroaryl, haloalkyl, hydroxyl, cyano, alkoxyl, aryloxy, aminoalkyl, hydroxyalkyl, heterocyclo alkyl, carboxyl, alkoxycarbonyl and —NR 9 R 10 ; R 11 is selected from the group consisting of hydrogen and alkyl; n is an integer from 2 to 6; z is an integer from 1 to 4; and r is an integer from 1 to 6.