Patent ID: 6878716

Claim:
A compound having the structure: wherein R 1 is trans-4-hydroxy cyclohexyl, 2-methylamino carbonylamino cyclohexyl, acetylamino ethyl, or methylamino carbonylamino ethyl; wherein R 3 is a substituted or unsubstituted phenyl, pyrrole, thiophene, furan, thiazole, imidazole, pyrazole, 1,2,4-triazole, 2(1H)-pyridone, 4(1H)-pyridone, pyrazine, pyrimidine, pyridazine, isothiazole, isoxazole, oxazole, tetrazole, naphthalene, tetralin, naphthyridine, benzofuran, benzothiophene, indole, 2,3-dihydroindole, 1H-indole, indoline, benzopyrazole, 1,3-benzodioxole, benzoxazole, purine, coumarin, chromone, quinoline, tetrahydroquinoline, isoquinoline, benzimidazole, quinazoline, pyrido[2,3-b]pyrazine, pyrido[3,4-b)pyrazine, pyrido[3,2-c]pyridazine, pyrido[3,4-b]-pyridine, 1H-pyrazole[3,4-d]pyrimidine, pteridine, 2(1H)-quinolone, 1(2H)-isoquinolone, 1,4-benzisoxazine, benzothiazole, quinoxaline, quinoline-N-oxide, isoquinoline-N-oxide, quinoxaline-N-oxide, quinazoline-N-oxide, benzoxazine, phthalazine or cinnoline; wherein R 5 is H, or a substituted or unsubstituted C 1 -C 30 alkyl, amino, benzene, pyrrole, furan, thiophene, imidazole, benzoxazole, benzothiazole, triazole, tetrazole, pyrazole, pyridine, pyrazine, pyridazine, pyrimidine, naphthyl, quinolyl, or indolyl, wherein said substituted alkyl is —C(R 7 ) (Ra)XR 9 , wherein X is O, S, or NR 10 ; wherein R 7 and R 8 are each independently H or alkyl; wherein R 9 and R 10 are each independently alkyl or cycloalkyl, or R 9 , R 10 and the nitrogen together form a substituted or unsubstituted morpholino, thiomorpholino, N-4-substituted piperazino, 2-substituted piperazine, R 8 substituted pyrrolidino, or piperidine ring; wherein R 8 is H, OH, CH 2 OH, —C(═O)NR 9 R 10 , or NR 11 ; wherein R 11 is —C(═O)CH 3 , or —SO 2 Me; and wherein R 6 is H, C 1 -C 30 alkyl, substituted C 1 -C 30 alkyl, or cycloalkyl, or a pharmaceutically acceptable salt of the compound, wherein any substituent, if present, is halogen, hydroxyl, alkoxy, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylthiocarbonyl, phosphate, phosphonato, phosphinato, cyano, amino, alkyl amino, dialkylamino, arylamino, diarylamino, alkylarylamino, acylamino, alkylcarbonylamino, arylcarbonylamino, carbamoyl, ureido, amidino, imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfate, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, cyano, or azido.