Patent ID: 7846959

Claim:
A compound according Formula IX, or a pharmaceutically acceptable salt thereof, wherein A is ortho-phenylene; n is zero to three; each R 1 is independently selected from —H, halogen, —CN, —NO 2 , —OR 3 , —N(R 3 )R 3 , —S(O) 0-2 R 3 , —SO 2 N(R 3 )R 3 , —CO 2 R 3 , —C(O)N(R 3 )R 3 , —N(R 3 )SO 2 R 3 , —N(R 3 )C(O)R 3 , —N(R 3 )CO 2 R 3 , —C(O)R 3 , —OC(O)R 3 , optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl; Z and X are each independently selected from —C(R 2 )═, —N═, —N(R 2 )—, —S(O) 0-2 —, and —O—; Y is selected from —C(R 2 )(R 2 )—, —C(═O)—, —C(R 2 )═ and —N═, but Y is not —N═ when both Z and X are —N═; each R 2 is independently selected from R 3 , —C(O)N(R 3 )R 3 , —N(R 3 )CO 2 R 3 , —N(R 3 )C(O)N(R 3 )R 3 , and —N(R 3 )C(O)R 3 ; each R 3 is independently selected from —H, optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-3 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-3 alkyl; optionally two of R 3 , when taken together with a common nitrogen to which they are attached, form an optionally substituted five- to seven-membered heterocyclyl, said optionally substituted five- to seven-membered heterocyclyl optionally containing at least one additional heteroatom selected from N, O, S, and P; R 4 is selected from —H, —OH, optionally substituted C 1-6 alkyl and optionally substituted C 1-6 alkoxy; and wherein each optionally substituted alkyl, aryl, and heterocyclyl group can independently be substituted with one to three groups selected from C 1-6 alkyl, aryl, arylC 1-6 alkyl, heterocyclylC 1-6 alkyl, heterocyclyl, alkoxy, amino, amidino, aryloxy, arylalkyloxy, carboxy, acyloxy, carboxyalkyl, carboxamido, benzyloxycarbonylamino, cyano, acyl, halogen, hydroxy, nitro, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, thiol, oxo, carbamyl, acylamino, hydrazino, hydroxylamino, and sulfonamido.