Patent ID: 7687514

Claim:
A compound of the formula (I), wherein A, and C are independently methine or nitrogen, said methine being optionally substituted by a substituent selected from the group consisting of halogen, cyano, lower alkyl, halo-lower alkyl, hydroxy, lower alkoxy, halo-lower alkoxy, lower alkoxycarbonyl, lower alkylsulfonyl, lower alkylsulfonyloxy, —N(R 1 )R 2 and —Q 1 —Ar 1 , and at least one of A, and C is said methine group, and B and D are nitrogen; Ar 1 is aryl or heteroaryl, any of which is optionally substituted by a substituent selected from the group consisting of halogen, nitro, hydroxy, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, cyclo-lower alkyl, lower alkenyl, lower alkoxy, halo-lower alkoxy, lower alkylthio, lower alkylsulfonyl, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkanoylamino and —Q 2 —Ar 2 ; Ar 2 is aryl or heteroaryl, any of which is optionally substituted by a substituent selected from the group consisting of halogen, cyano, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxy, lower alkoxy, halo-lower alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl; E is methine or hydroxy substituted methine; n is 0 or 1; Q 1 and Q 2 are independently a single bond, oxygen, carbonyl or —N(R 3 )—; R 1 and R 2 are independently hydrogen or lower alkyl, or R 1 and R 2 , taken together, form lower alkylene which may be intervened by oxygen, sulfur or imino; R 3 is hydrogen or lower alkyl; R 4 is lower alkyl, aralkyl or aryl; R 5 and R 8 are independently hydrogen, lower alkyl, aralkyl or aryl; R 6 and R 7 are independently hydrogen, hydroxy, lower alkyl, aralkyl or aryl; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted by a substituent selected from the group consisting of halogen, lower alkyl, halo-lower alkyl, hydroxy, lower alkoxy and halo-lower alkoxy, and at least two of T, U, V and W are said methine group; X is —N(SO 2 R 4 )—, —N(COR 5 )— or —CO—; Y is —C(R 6 )(R 7 )—, —O— or —N(R 8 )—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO— and Y is —O— is excluded, and a pharmaceutically acceptable salt, ester or N-oxide derivative thereof.