Patent ID: 8877801

Claim:
A compound of formula I: in which: n is selected from 0, 1 and 2; m is selected from 0, 1 and 2; X is selected from O and NR 6 ; wherein R 6 is C 1-4 alkyl; Y 1 is selected from N and CR 7 ; wherein R 7 is selected from hydrogen and C 1-4 alkyl; R 1 is hydrogen; R 2 is selected from hydrogen and halo; R 3 is selected from —CH 2 CH 2 R 8b and —CR 8a ═CR 8a R 8b ; wherein each R 8a is independently selected from hydrogen, fluoro and C 1-4 alkyl; and R 8b is selected from —C(O)OR 9a , —C(O)NR 9a R 9b , —C(O)NHOR 9a , —C(O)X 2 R 9a and a 5-6 member heteroaryl selected from: wherein the dotted line indicates the point of attachment with —CH 2 CH 2 or —CR 8a ═CR 8a of R 3 ; wherein X 2 is C 1-4 alkylene; R 9a and R 9b are independently selected from hydrogen, C 1-4 alkyl, hydroxy-substituted-C 1-4 alkyl and halo-substituted-C 1-4 alkyl; wherein said heteroaryl of R 8b is unsubstituted or substituted with a group selected from C 1-4 alkyl and C 3-8 cycloalkyl; R 4 is selected from hydrogen, C 1-4 alkyl, halo and C 1-3 alkoxy; R 5 is selected from C 6-10 aryl and a 5-6 member heteroaryl selected from: wherein the dotted line indicates the point of attachment with the benzothiophene core; wherein said C 6-10 aryl or heteroaryl of R 5 is substituted with 1 to 3 R 5a groups independently selected from hydroxy, amino, C 1-4 alkyl, halo, nitro, cyano, halo-substituted-C 1-4 alkyl, cyano-substituted-C 1-4 alkyl, hydroxy-substituted-C 1-4 alkyl, halo-substituted-C 1-4 alkoxy, C 1-4 alkoxy, —SF 5 , —NR 11a R 11b , —C(O)R 11a and a 4-7 member saturated ring containing one other heteroatom or group selected from O, NH, and S(O) 0-2 ; wherein R 11a and R 11b are independently selected from hydrogen and C 1-4 alkyl; or R 11a and R 11b together with the nitrogen to which they are both attached form a 4 to 7 member saturated ring containing one other heteroatom or group selected from O, NH, and S(O) 0-2 ; wherein said 4-7 member ring of R 5a can be unsubstituted or substituted with C 1-4 alkyl; or a pharmaceutically acceptable salt thereof.