Patent ID: 8604034

Claim:
A compound of formula (I): wherein represents single or double bonds depending on the required valencies of the ring atoms; each Y is CH; X is CH; X 1 is selected from O, S, NR 6 , and C(R 6 ) 2 wherein each R 6 is independently selected from H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocyclyl and optionally substituted aryl; X 2 is C(R 3 R 4 ) wherein R 3 and R 4 are each independently selected from H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocyclyl and optionally substituted aryl; R 1 is optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocyclyl or optionally substituted aryl; R 2 is H, R 8 , C(═O)R 8 , C(═S)R 8 or S(O) 2 R 8 wherein R 8 is selected from optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, N(R 6 ) 2 , optionally substituted —(NR 6 ) q (R 7 ) q cycloalkyl, optionally substituted —(NR 6 ) q (R 7 ) q heterocyclyl and optionally substituted —(NR 6 ) q (R 7 ) q aryl wherein each R 7 is independently selected from optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocyclyl and optionally substituted aryl and each q independently is 0 or 1; Y 1 is one or more optional substituents, or is absent; Y 2 is H or one or more optionally substituted R 7 ; m is 1; n is 1; p is 2; and wherein the optional substituents are independently selected from R 7 , R 7 —R 7 , (R 7 ) q halo, (R 7 ) q CN, ═O, (R 7 ) q OR 6 , (R 7 ) q OCHF 2 , (R 7 ) q OCF 3 , (R 7 ) q CHF 2 , (R 7 ) q CF 3 , ═S, (R 7 ) q SR 6 , (R 7 ) q SO 3 H, (R 7 ) q SO 2 —R 7 , (R 7 ) q SO 2 N(R 6 ) 2 , (R 7 ) q NO 2 , (R 7 ) q N(R 6 ) 2 (R 7 ) q OC(═O)—R 7 , (R 7 ) q C(═O)OR 6 , (R 7 ) q C(═O)R 6 , (R 7 ) q C(═O)N(R 6 ) 2 , (R 7 ) q NR 6 C(═O)—R 7 , (R 7 ) q NR 6 SO 2 R 7 , (R 7 ) q Si(R 7 ) 3 and (R 7 ) q O—Si(R 7 ) 3 ; or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof.