Patent ID: 8506993

Claim:
A method for making multifunctional polymerized liposomes comprising the steps of: providing a lipid solution comprising clickable lipids of the general formula R 1 —(CH 2 ) m —≡—≡—((CH 2 ) n —R 2 , wherein R 1 and R 2 are organic groups containing at least one clickable group chosen from an ethynyl group and an azido group, and m and n are integers that vary independently from 1-30; treating the lipid solution to form clickable liposomes; polymerizing the clickable liposomes by cooling and UV light irradiation; and clicking the polymerized clickable liposomes with the at least one clickable group chosen from an azido group and an ethynyl group in the presence of a catalyst for the click reaction; wherein the catalyst comprises a compound formed in situ by the addition of a water soluble triazole ligand and ascorbic acid to copper sulfate, wherein the water soluble triazole ligand comprises oligo-ethylene glycol.