Patent ID: 8420666

Claim:
A compound having the structure of Formula I: or its pharmaceutically acceptable salts, wherein R 1 and R 2 independently are hydrogen, aryl, heteroaryl, —COR 4 , —S(O) m R 4 (wherein R 4 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or heterocyclyl and m is an integer from 0-2), wherein X is —O—, S(O) m (wherein m is an integer from 0-2), C(═O), C═NOH, CR f R q (wherein R f and R q independently are hydrogen, hydroxy, carboxy or cyano) or NR 5 {wherein R 5 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl, —COR 4 , —S(O) m R 4 , —COOR 4 or —CONR 4 R′ 4 (wherein R 4 and R′ 4 independently are hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or heterocyclyl and m is an integer from 0-2)}; R 3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, aralkenyl, cycloalkylalkyl, heterocyclyl, heteroaryl, heterocyclylalkyl or heteroarylalkyl; M is a 3-7 membered saturated, partially saturated or unsaturated ring containing carbon atoms wherein one or more carbon atoms optionally are replaced by heteroatoms selected from O, S(O) m {wherein m is an integer from 0-2} or NR 6 {wherein R 6 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl, —COR 4 , —S(O) m R 4 , —COOR 4 or —CONR 4 R′ 4 (wherein R 4 and R′ 4 independently are hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or heterocyclyl and m is an integer from 0-2)}, or one or more carbon atoms optionally are substituted with oxo, halogen, spiro-attached heterocyclyl, hydroxy, cyano, alkyl, heteroaryl, heteroarylalkyl, —(CH 2 ) m NR 4 R′ 4 , —(CH 2 ) m OR 4 , —(CH 2 ) m CONR 4 R′ 4 , —(CH 2 ) m NR 4 COR 4 , or —(CH 2 ) m COOR 4 (wherein m, R 4 and R′ 4 are the same as defined above).