Patent ID: 8367347

Claim:
A method for the estimation of a prognosis for human patients having a brain tumor, comprising (a) obtaining a brain tumor sample from a patient; and (b) determining the presence of a mutation at position 132 of isocitrate dehydrogenase (IDH1) on the protein level using an antibody that can distinguish between an IDH1 protein harbouring said mutation and an unmutated version of the protein, wherein the mutation is R132H and wherein said antibody is raised using the peptide CKPIIIGHHAYGD (SEQ ID NO: 1) as an immunogen and generated by a hybridoma having accession number DSM ACC3009; whereby a patient having a brain tumor and harbouring said mutation has a better prognosis than a patient without said mutation wherein the tumor is a glioma and selected from anaplastic astrocytoma WHO grade III, anaplastic oligoastrocytoma WHO grade III, and anaplastic oligodendroglioma grade III.