Patent ID: 8338374

Claim:
A formulation consisting of a therapeutically effective amount of a human growth hormone in an aqueous solution, a buffer that maintains the pH of the formulation at a pH of 5 to 7, a non-ionic polysorbate surfactant, a polymer stabilizer wherein said polymer stabilizer is a polyethylene glycol which has a molecular weight in the range of about 3000 to about 20,000, methionine, and one or more optional excipients selected from the group consisting of a divalent cation present in a magnesium salt selected from the group consisting of magnesium hydroxide, magnesium chloride, magnesium sulfate, magnesium citrate, and magnesium edentate; a tonicity agent; and a preservative, wherein the formulation remains stable after at least one freezing and subsequent thawing event.