Patent ID: 7405225

Claim:
A compound of formula (I): wherein: R 1 is (a) phenyl or heteroaryl selected from furanyl, thienyl, pyridyl, optionally substituted with one to two R 3 , (b) R 6 (CH 2 ) m O—, (c) R 6 OCH 2 —, (d) R 6 (CH 2 ) m NH—, (e) R 6 (CH 2 ) p (CH═CH) m —, (f) C 1-6 alkyl, optionally partially or fully halogenated and optionally substituted with one to two R 9 , (g) C 1-8 alkoxy, optionally partially of fully halogenated and optionally substituted with one to two R 9 , (h) C 1-8 alkylthio, (i) —N(R 4 )(R 5 ), or (j) —C(O)NHR′, wherein R′ is R 6 , pyridyl or —CH 3 , R 2 is (a) heterocyclyl wherein said heterocycle is selected from from 1-piperidinyl, 1-piperazinyl, 4-morpholinyl, 1-pyrrolidinyl, 1,4-diazacycloheptan-1-yl, 1-azepanyl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, oxazepan-4-yl and 4-thiomorpholino and is optionally substituted with one to three R 7 , (b) heterocyclylCH 2 O— wherein the heterocyclyl is selected from 1-piperidinyl, 1-piperazinyl, 4-morpholinyl and 1-pyrrolidinyl, optionally substituted with C 1-6 alkyl, or C—N(R 4 )(R 5 ); R 3 is chosen from C 1-6 alkyl, C 1-6 alkoxy, hydroxyC 1-6 alkyl, halogen, —CN, —CO 2 H, —CO 2 C 1-6 alkyl, —S(O) n C 1-6 alkyl, —NO 2 , —OH, —CF 3 , —N(R 4 )(R 5 ), —NHC(O)NHC 1-6 alkyl, —C(O)N(R 4 )(R 5 ) and phenyl optionally substituted with halogen, C 1-6 alkyl, —CN or C 1-6 alkoxy; R 4 and R 5 are independently selected from H, C 1-6 alkyl, —C(O)C 1-6 alkyl, pyridyl, benzyl, piperidinyl and phenylethyl; R 6 is a phenyl group optionally substituted with one or two groups selected from Cl, F, C 1-6 alkyl, —CN, CO 2 C 1-6 alkyl, C(O)NR 4 R 5 , —SO 2 NR 2 , —NO 2 , —OH, —NH 2 , —CF 3 and C 1-6 alkoxy or R 6 is C 3-6 cycloalkyl, —CH 2 OH, naphthalene-2-yl, naphthalene-1-yl or 2-thienyl; R 7 is selected from —OH, —CN, oxo, —CO 2 C 1-6 alkyl, —C(O)N(R 4 )(R 5 ), —N(R 4 )(R 5 ), —CH 2 N(R 4 (R 5 ), CH 2 OH, C 1-6 alkyl, —C(O)C 1-6 alkylN(R 4 )(R 5 ), —NHC(O)N(R 4 )(R 5 ), —S(O) n C 1-6 alkyl, H 2 NCH(R 8 )C(O)—, HO(CH 2 ) m CH 2 CH(NH 2 )C(O)—, HOCH(R 6 )CH 2 NH— and —C(O)heterocyclyl, wherein said heterocyclyl is selected from piperidinyl, piperazinyl, morpholinyl and pyrrolidinyl, or R 7 is 2-hydroxyethylamino, methylcarbamimidoyl, hydroxyimino, hydrozinocarbonyl, sulfamoyl, methanesulfonylamino, methylsulfonylhydrazino, 2-hydroxypropylamino, 2,3-dihydroxypropylamino, 2-hydroxy-1-methylethylamino, carbamoylmethylamino, N′-phenylhydrazinocarbonyl or toluene-4-sulfonylamino; R 8 is selected from C 1-6 alkyl, —(CH 2 ) 1-4 NH 2 , phenyl or benzyl; R 9 is —OH; R 10 is selected from —OH, —N(R 4 (R 5 ), C 1-6 alkoxy and heteroaryl selected from furanyl, thienyl and pyridyl; m is 0 or 1; n is 0, 1 or 2; and p is 0, 1, 2 or 3; or a pharmaceutically acceptable salt, racemate, racemic mixture, single enantiomer, diastereomeric mixture or an individual diastereomer thereof.