Patent ID: 6916791

Claim:
A method for inhibiting conception by administering to a male in need thereof an effective amount of a compound of Formula (III): wherein the dotted line represents a single or double bond; the rings P and Q are, independently, saturated or partially unsaturated; R is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue, or R is an orthoester glycoside moiety of the Formula (IV): wherein the semi-dotted ring indicated at “C” is a glycofuranosyl or glycopyranosyl ring; R 8 is hydrogen; C 1-4 alkyl; C 7-10 aralkyl; phenyl; phenyl substituted by chloro, fluoro, bromo, iodo, C 14 alkyl or C 14 alkoxy; or is naphthyl; R 9 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycoside units; R 1 is hydrogen C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkanoyl or R 1 and R, together with the atoms to which they are attached, form a carbonyl group; R 2 is hydrogen or C 1-4 alkyl; R 3 is hydrogen or hydroxy; R 4 , where present, is hydrogen or a halogen atom; R 5 , where present, is hydrogen or C 1-4 alkyl; R 6 is hydrogen or C 1-4 alkyl; R 14 , is hydrogen or C 1-4 alkyl; A is oxygen, ═CH, >C═CHOH, or is the group >CHR 13 , wherein R 13 is hydrogen or a C 1-4 alkyl group, or A and B together form an optionally substituted pyrazole or isoxazole ring; B is a carbonyl group, ═CH, >CH 2 >CHOR 7 or ═C(OR 7 )—, wherein R 7 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycoside units, or R 7 is an orthoester glycoside moiety of the Formula (V): wherein the semi-dotted ring indicated at “D” represents a glycofuranosyl or glycopyranosyl ring; R 10 is hydrogen; C 1-4 alkyl; C 7-10 aralkyl; phenyl; phenyl substituted by chloro, fluoro, bromo, iodo, C 1-4 alkyl or C 1-4 alkoxy; or is naphthyl; and R 11 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycoside units; and esters thereof; provided that when R is hydrogen, then B is >CHOR 7 or ═C(OR 7 )—, and R 7 is a glycosidic residue or orthoester glycoside moiety, wherein said compound is administered orally.