Patent ID: 8618138

Claim:
A compound of structural formula (A5), or a stereoisomer, enantiomer, or tautomer thereof, wherein, R 5 is selected from the group consisting of halogen; â€”OH; â€”OR 10 ; â€”SH; â€”SR 10 ; â€”S(O)R 11 ; â€”S(O) 2 R 11 ; â€”SO 2 NR 12 R 13 ; trifluoromethyl; trifluoromethoxy; nitro; â€”NHC(O)R 10 ; â€”NHS(O) 2 R 10 ; â€”NHC(O)NR 12 R 13 ; â€”NR 10 C(O)R 10 ; â€”NR 10 S(O) 2 R 10 ; â€”NR 10 C(O)NR 12 R 13 ; â€”NR 12 R 13 ; -cyano; â€”COOH; â€”COOR 10 ; â€”C(O)NR 12 R 13 ; â€”C(O)R 11 ; alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene; and heterocycle-alkynylene; L is a single bond or is independently selected from the group consisting of â€”Oâ€”; â€”NHâ€”; â€”NR 10 â€”; C 1-6 alkylene; C 1-6 alkenylene; and C 1-6 alkynylene, wherein each of said C 1-6 alkylene, C 1-6 alkenylene or C 1-6 alkynylene optionally includes one or more heteroatoms, said heteroatoms being selected from the heteroatoms consisting of S and N, and wherein each of said C 1-6 alkylene, C 1-6 alkenylene or C 1-6 alkynylene, can be unsubstituted or substituted; and wherein a carbon atom or heteroatom of said C 1-6 alkylene, C 1-6 alkenylene or C 1-6 alkynylene, can be oxidized to form a Câ•O, Câ•S, Nâ•O, Nâ•S, Sâ•O or S(O) 2 ; B is cyclic structure selected from the group consisting of cycloalkyl; cycloalkenyl; cycloalkynyl; aryl; and heterocycle; R 8 is independently selected from the group consisting of hydrogen; halogen; alkyl; alkenyl; alkynyl; â€”OH; â€”OR 10 ; â€”SH; â€”SR 10 ; â€”S(O)R 11 ; â€”S(O) 2 R 11 ; â€”SO 2 NR 12 R 13 ; trifluoromethyl; trifluoromethoxy; nitro; â€”NHC(O)R 10 ; â€”NHS(O) 2 R 10 ; â€”NHC(O)NR 12 R 13 ; â€”NR 10 C(O)R 10 ; â€”NR 10 S(O) 2 R 10 ; â€”NR 10 C(O)NR 12 R 13 ; â€”NR 12 R 13 ; -cyano; â€”COOH; â€”COOR 10 ; â€”C(O)NR 12 R 13 ; and â€”C(O)R 11 ; m is selected from the group consisting of 0; 1; 2; 3; 4 and 5; each R 10 is independently selected from the group consisting of alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene; and heterocycle-alkynylene; each R 11 is independently selected from the group consisting of hydroxyl; alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene; and heterocycle-alkynylene; each R 12 and R 13 is independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene; and heterocycle-alkynylene; or wherein R 12 and R 13 are taken together to form a 5-, 6-, or 7-membered unsubstituted or substituted heterocycle; or a solvate, hydrate, salt or prodrug thereof, wherein the compound is not 3-isoxazolecarboxamide, 5-(4-chlorophenyl)-N-[2-(5-methyl-1H-indol-3-yl)ethyl]-.