Patent ID: 8846862

Claim:
A process for the solid phase synthesis of peptides, which comprises: deprotecting a first Fmoc-protected amino acid linked to solid phase resin particles selected from the group consisting of Wang resins, Trityl resins and Rink resins by removing the Fmoc protective chemical group from the first acid; activating chemical groups on a second Fmoc-protected amino acid to prepare the second amino acid for coupling with the first amino acid; coupling the activated second amino acid to the deprotected first amino acid to form a peptide from the first and second amino acids; accelerating at least the deprotecting and coupling steps by applying microwave energy during the deprotecting and coupling steps; controlling the application of microwave energy to avoid excessive heat; and successively deprotecting, and coupling a plurality of Fmoc-protected amino acids into a peptide in the single microwave transparent vessel without removing the peptide from the single vessel between cycles.