Patent ID: 6916957

Claim:
A tryptase inhibitor compound of formula (I) where: R 5 represents amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen; R 6a represents hydrogen or methyl; X—X is selected from the group consisting of —CH═CH—, —CONR 1a —, —NH—CO—, —NR 1a —CH 2 —, —CH 2 —NR 1a , —CH 2 —, —OCH 2 —, —COO—, —OC—O— and —CH 2 CH 2 —; R 1a represents hydrogen, (1-6C)alkyl or phenyl(1-6C)alkyl; L is CO or CONR 1d (CH 2 ) m in which m is 0 or 1 and R 1d is hydrogen, (1-6C)alkyl or phenyl(1-6C)alkyl; Cy is phenyl optionally substituted by R 3a or R 31 X i in which X i is a bond, O, NH or CH 2 and R 3i is phenyl optionally substituted by R 3a ; each R 3a independently is hydrogen, hydroxyl, (1-6C)alkoxy, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkanoyl, (1-6C)alkylaminoalkyl, hydroxy(1-6C)alkyl, carboxy, (1-6C)alkoxyalkyl, (1-6C)alkoxycarbonyl, (1-6C) alkylaminocarbonyl, amino(1-6C)alkyl CONH 2 , CH 2 CONH 2 , aminoacetyl, (1-6C)alkanoylamino, (1-6C)alkoxycarbonylamino, amino, halo, cyano, nitro, thiol, (1-6C)alkylthio, (1-6C)alkylsulphonyl, (1-6C)alkylsulphenyl, imidazolyl, hydrazido, (1-6C)alkylimidazolyl, (1-6C)alkylsulphonamido, (1-6C)alkylaminosulphonyl, aminosulphonyl, (1-6C)haloalkoxy, or (1-6C)haloalkyl; and Lp is an alkyl, alkenyl or carbocyclic group, or a combination of two or more such groups linked by a spiro linkage or a single or double bond or by C═O, O, OCO, COO, S, SO, SO 2 , CONR 1e, NR 1e —CO— or NR 1e linkage (where R 1e is as defined for R 1a ), optionally substituted by one or more oxo or R 3 groups in which R 3 is an amino acid residue, N-(1-6C)alkylaminocarbonyl, N,N-di(1-6C)alkylaminocarbonyl, N-(1-6C)alkylaminoalkanoyl, N-(1-6C)alkanoylamino(1-6C)alkanonyl, C-hydroxyamino(1-6C)alkanoyl, hydroxy(2-6C)alkanoylamino(1-6C)alkanoyl, di(1-6C)alkylaminosulfonyl, hydrogen, hydroxyl, (1-6C)alkoxy, (1-6C)alkanoyloxy, (1-6C)alkyl, (2-6C)alkenyl (2-6C)alkynyl, (3-6C)alkenyloxycarbonyl, (1-6C)alkanoyl, amino(1-6C)alkyl, amido (CONH 2 ), amino(1-6C)alkanoyl, aminocarbonyl(1-5C)alkanoyl, hydroxy(1-6C)alkyl, carboxy, hydroxy(1-6C)alkanoyl, (1-6C)alkoxy(1-6C)alkyl, (1-6C)alkoxycarbonyl (1-5C)alkyl, (1-6C)alkoxycarbonyl, (1-6C)alkanoylamino, amino, halo, cyano, nitro, thiol, (1-6C)alkylthio, (1-6C)alkylsulfonyl, (1-6C)alkylsulphenyl or hydrazido; provided that the compound of formula I is not 3-aminomethylbenzoyl-D-phenylglycine-4-aminomethylcyclohexyl-methylamide or 3-aminomethylbenzoyl-D-phenylglycine-1-adamantylamide; or a physiologically tolerable salt thereof.