Patent ID: 7435833

Claim:
A compound of formula (I) wherein: n is 1; R 1 is each of which is independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, —CN,—NO 2 ,—OR b , —SR b , —S(O)R Z ,—S(O) 2 R Z ,—NR a R b ,—C(O)R b , —C(O)OR b ,—C(O)NR a R b , —S(O) 2 NR a R b , —C(═NOH)NH 2 , —C(═NH)NH 2 , —R c , —(CR d R c ) m —CN, —(CR d R c ) m —OR b , —(CR d R c ) m—SR b ,—(CR d R c ) m —S(O) 2 R Z , —(CR d R c ) m —NR a R b , —(CR d R c ) m —C(O)R b , —(CR d R c ) m —C(O)OR b , —(CR d R c ) m —S(O) 2 NR a R b , —(CR d R c ) m —R c , —N(R a )—(CR d R c ) m —C(O)OR b , —N(R a )—(CR d R c ) m —C(O)OR b , —N(R a )—(CR d R c ) m —C(O)NR a R b , —O—(CR d R c ) m —C(O)R b , —O—(CR d R c ) m —C(O)OR b , and —O—(CR d R c ) m —C(O)NR a R b ; R 2 and R 3 , at each occurrence, are each independently hydrogen or alkyl; R 4 is —(CR d R c ) m -E-G, wherein E, at each occurrence, is independently O or N(R c ), and G, at each occurrence, is independently phenyl or pyridinyl, wherein each G is independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, —CN, —NO 2 , —OR d , —S(R d ), —S(O)(alkyl), —S(O)(haloalkyl), —S(O) 2 (alkyl), —S(O) 2 (haloalkyl), —NR d R c , —C(O)(R d ), —C(O)OR d , —C(O)NR d R c , —S(O) 2 NR d R c , —R c , —(CR d R c ) m —CN, —(CR d R c ) m —NO 2 , —(CR d R c ) m —OR d , —(CR d R c ) m —S(R d ), —(CR d R c ) m —S(O)(alkyl), —(CR d R c ) m —S(O)(haloalkyl), —(CR d R c ) m —S(O) 2 (alkyl), —(CR d R c ) m —S(O) 2 (haloalkyl), —(CR d R c ) m —NR d R c , —(CR d R c ) m —C(O)(R d ), —(CR d R c ) m —C(O)OR d , —(CR d R c ) m —C(O)NR d R c , —(CR d R c ) m —S(O) 2 NR d R c , and —(CR d R c ) m —R c ; R a , at each occurrence, is independently hydrogen or alkyl; R b , at each occurrence, is independently hydrogen, alkyl,. haloalkyl, R c or —(CR d R c ) m —R c ; R Z , at each occurrence, is independently alkyl, haloalkyl, R c or —(CR d R c ) m —R c ; R c , at each occurrence, is heteroaryl wherein heteroaryl is imidiazolyl, triazolyl and tetrazolyl, wherein each R c is independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, —CN, —NO 2 , —OR d ,—S(R d ), —S(O)(alkyl), —S(O)(haloalkyl), —S(O) 2 (alkyl), —S(O) 2 (haloalkyl), —NR d R c , —C(O)(R d ), —C(O)OR d , —C(O)NR d R c , —S(O) 2 NR d R c , —(CR d R c ) m —CN, —(CR d R c ) m —NO 2 , —(CR d R c ) m —OR d , —(CR d R c ) m —S(R d ), —(CR d R c ) m —S(O)(alkyl), —(CR d R c ) m —S(O)(haloalkyl), —(CR d R c ) m —S(O) 2 )(alkyl), —CR d R c ) m —S(O) 2 (haloalkyl), —(CR d R c ) m —NR d R c , —(CR d R c ) m —C(O)(R d ), —(CR d R c ) m —C(O)OR d , —(CR d R c ) m —C(O)NR d R c , and —(CR d R c ) m —S(O) 2 NR d R c ; R d and R c , at each occurrence, are independently hydrogen or alkyl; and m is 1; or a pharmaceutically acceptable salt thereof, or a combination thereof.