Patent ID: 8580756

Claim:
An oligomer 10-14 nucleobase units in length, wherein the nucleobase sequence of said oligomer comprises the formula (5′-3′), AB-C, wherein: region A (5′ region) comprises 1-3 contiguous locked nucleic acid (LNA) nucleobase units; region B (central domain) comprises 7-9 contiguous nucleobase units and is capable of recruiting RNase H when formed in a duplex with a complementary RNA molecule; and region C (3′ region) comprises 1-3 contiguous locked nucleic acid (LNA) nucleobase units; and wherein 1, 2 or 3 internucleoside linkages adjacent to an LNA unit in region A, region C, or in each of regions A and C are phosphodiester linkages; and wherein the remaining internucleoside linkages are phosphorothioate linkages.