Patent ID: 7732405

Claim:
An aqueous and pharmaceutically acceptable composition comprising (i) at least 0.01 mg/mL of a Factor VII polypeptide that exhibits substantially the same or improved biological activity as compared to wild type Factor VII; (ii) a buffering agent suitable for keeping pH of the composition in the range of about 4 to about 9; and (iii) a stabilizing composition comprising a benzamidine compound comprises the motif >N—C 6 H 4 —C(═N-Z 1 -R 1 )—NH-Z 2 -R 2 , wherein (a) C 6 H 4 denotes a substituted benzene ring, and (b) Z 1 and Z 2 independently are selected from the group consisting of —O—, —S—, —NR H — and a single bond, where R H is selected from the group consisting of hydrogen, C 1-4 alkyl, aryl and arylmethyl, and R 1 and R 2 independently are selected from the group consisting of hydrogen, optionally substituted C 1-6 -alkyl, optionally substituted C 2-6 -alkenyl, optionally substituted aryl, and optionally substituted heterocyclyl, wherein —C═N-Z 1 -R 1 optionally forms part of a heterocyclic ring, —C—NH-Z 2 -R 2 optionally forms part of a heterocyclic ring, or —C(═N-Z 1 -R 1 )—NH-Z 2 -R 2 optionally forms a hetercyclic ring wherein -Z-R 1 —R 2 -Z 2 is a biradical.