Patent ID: 8329888

Claim:
An RNA complex, capable of mediating RNA interference, comprising a core substantially double-stranded region of between 18-23 base pairs, said core substantially double stranded region consisting of an antisense strand and a discontinuous passenger strand; wherein the discontinuous passenger strand is hybridized to the antisense strand, and; wherein the discontinuity in the passenger strand is a nick or a gap of 1 nucleotide, and; wherein the RNA complex comprises one or more LNA units, and; wherein the discontinuous passenger strand comprises at least a first and a second RNA-molecule, and; wherein the first RNA molecule of the discontinuous passenger strand is 8-13 nucleobases in length and the second molecule of the discontinuous passenger strand is 8-14 nucleobases in length, and; wherein first and second RNA molecules of the passenger strand each comprises at least one LNA unit.