Patent ID: 8563553

Claim:
A method to treat cancer mediated by Raf kinase, comprising administering to a subject in need of such treatment a pharmaceutically effective amount of a compound of Formula I: wherein: R1 is —X1NHC(O)OR1a, where X1 is a (C1-C4)alkylene optionally substituted with 1 to 3 groups each independently selected from (C1-C4)alkyl or halosubstituted(C1-C4)alkyl and R1a is (C1-C2)alkyl or halosubstituted(C1-C2)alkyl; R1b is H or methyl; R2 is H or F; R3 is H, halogen, (C1-C2)alkoxy, (C1-C2)alkyl, halosubstituted(C1-C2)alkoxy, or halosubstituted(C1-C2)alkyl; R4 is H or methyl; R5 is (C1-C4)alkyl, (C3-C5)branched alkyl, halosubstituted(C1-C4)alkyl, or halosubstituted(C3-C6)branched alkyl; R6 is H, (C1-C2)alkyl, or halogen; and R7 is (C3-C6)cycloalkyl, 1-methyl-(C3-C6)cycloalkyl, or (C3-C6)branched alkyl; or a pharmaceutically acceptable salt thereof.