Patent ID: 7560546

Claim:
A compound as illustrated by Formula II: wherein: ----- represents an optional double bond; X is C, N, S(O) m or O; G is H 2 or O; R a is independently selected from: 1) H, 2) C 1 -C 6 alkyl, 3) Halogen, 4) Aryl, 5) Heterocycle, 6) C 3 -C 10 cycloalkyl, and 7) OR 4 ; said alkyl, aryl, heterocycle and cycloalkyl is optionally substituted with at least one substituent selected from R 7 ; R 1 is independently selected from: (CR a 2 ) n R 6 , (CR a 2 ) n C(O)R 4 , C(O)N(R 4 ) 2 , (CR a 2 ) n OR 4 , (CR a 2 ) n N(R 4 ) 2 , S(O) m R 6 , S(O) m R 6 OR 4 , C(O)N(R 4 )(CR a 2 ) n R 6 , C(O)N(R 4 )(CR a 2 ) n OR 4 , C(O)R 6 (CR a 2 ) n R 6 , C(O)N(R 4 )(CR a 2 ) n S(O) m (CR a 2 ) n R 6 , C(O)N(R 4 )(CR a 2 ) n C(O)R 6 , C(O)N(R 4 )(CR a 2 ) n N(R 4 ) 2 , Halogen, N(R 4 )S(O) m R 6 , and (CR a 2 ) n C(O)OR 4 ; R 2 is: NH 2 ; R 4 independently selected from: 1) H, 2) C 1 -C 6 alkyl, 3) C 3 -C 10 cycloalkyl, 4) Aryl, 5) Heterocycle, 6) CF 3 , 7) C 2 -C 6 alkenyl, and 8) C 2 -C 6 alkynyl; said alkyl, cycloalkyl, aryl, heterocycle, alkenyl and alkynyl is optionally substituted with at least one substituent selected from R 7 ; R 5 is independently selected from: 1) H, 2) Halogen, 3) NO 2 , 4) CN, 5) CR 4 ═C(R 4 ) 2 , 6) C≡CR 4 , 7) (CR a 2 ) n OR 4 , 8) (CR a 2 ) n N(R 4 ) 2 , 9) C(O)R 4 , 10) C(O)OR 4 , 11) (CR a 2 ) n R 4 , 12) S(O) m R 6 , 13) S(O) m N(R 4 ) 2 , 14) OS(O) m R 6 , 15) N(R 4 )C(O)R 4 , 16) N(R 4 )S(O) m R 6 , 17) (CR a 2 ) n N(R 4 )R 6 , 18) (CR a 2 ) n N(R 4 )R 6 OR 4 , 19) (CR a 2 ) n N(R 4 )(CR a 2 ) n C(O)N(R 4 ) 2 , 20) N(R 4 )(CR a 2 ) n R 6 , 21) N(R 4 )(CR a 2 ) n N(R 4 ) 2 , and 22) (CR a 2 ) n C(O)N(R 4 ) 2 ; R 6 is independently selected from: 1) C 1 -C 6 alkyl, 2) Aryl, 3) Heterocycle, and 4) C 3 -C 10 cycloalkyl; said alkyl, aryl, heterocycle and cycloalkyl is optionally substituted with at least one substituent of R 7 ; R 7 is independently selected from: 1) Unsubstituted or substituted C 1 -C 6 alkyl, 2) Halogen, 3) OR 4 , 4) CF 3 , 5) Unsubtituted or substituted aryl, 6) Unsubstituted or substituted C 3 -C 10 cycloalkyl, 7) Unsubstituted or substituted heterocycle, 8) S(O) m N(R 4 ) 2 , 9) C(O)OR 4 , 10) C(O)R 4 , 11) CN, 12) C(O)N(R 4 ) 2 , 13) N(R 4 )C(O)R 4 , 14) S(O) m R 6 , and 15) NO 2 ; m is independently 0,1 or 2; n is independently 0, 1, 2, 3, 4, 5 or 6; s is 0 to 6; t is 0, 1, or 2; v is 0, 1 or 2; w is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt or stereoisomer thereof.