Patent ID: 8063082

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein W 1 is wherein W 1a , W 1b , and W 1c are each N; W 2 is CR 1 R 2 ; Z 1 is aryl; Z 2 is aryl; R 1 and R 2 are each methyl; for each occurrence, R 3 , R 4 , R 5 and R 6 are independently selected from hydrogen, hydroxy, carboxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted aminocarbonyloxy, optionally substituted acyloxy, optionally substituted alkoxycarbonyloxy, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted amino, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted aminocarbonyl, and optionally substituted aminosulfonyl; each R 7 and R 10 is independently selected from hydrogen, cyano, halo, hydroxy, carboxy, azido, nitro, sulfonyl, sulfinyl, sulfanyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbaminodoyl; R 8 and R 14 are independently selected from hydrogen, and optionally substituted alkyl; m is selected from 0, 1, 2 and 3; n is selected from 1 and 2; p is selected from 0, 1, 2, and 3; and q is selected from 0, 1, 2 and 3.