Patent ID: 7026281

Claim:
A method of suppressing excessive levels of GH in a patient in need of same which comprises administering to said patient an effective amount of a peptide selected from the group having the formulae: X—R 1 —R 2 -Asp-Ala-R 5 —R 6 -Thr-R 8 —R 9 —R 10 -Arg-R 12 —R 13 —R 14 —R 15 —R 16 Leu-R 18 —R 19 -Arg-R 21 —R 22 -Leu-Gln-Asp-Ile-R 27 —R 28 —R 29 —NH 2 wherein X is PhAc, IndAc, or Nac, R 1 is Tyr or His, R 2 is D-Ag [or D-Cit], R 5 is Ile or Val, R 6 is Phe, Nal or Phe(Y), in which Y=Cl, R 8 is Asn, Gln, Ala, or D-Asn, R 9 is Arg, Har, Lys, Om, D-Arg, D-Har, D-Lys, D-Om, Cit, Nle, Tyr (Me), Ser, Ala or Aib, R 10 is Tyr or or Tyr(Me), R 12 is Lys, R 13 is Val or NIe, R 14 is Leu or Nle, R 15 is Gly, Ala, Abu, Nle or Gln, R 16 is Gln or Arg, R 18 is Ser or Nle, R 19 is Ala, R 21 is Lys, R 22 is Leu, Ala or Aib, R 27 is Met, Leu, Nle, Abu, or D-Arg, R 28 is Arg, D-Arg, or Ser, R 29 is Arg, D-Arg, Har or D-Har, provided that where R 9 and R 28 are Ser, R 29 is other than Arg or Har, and pharmaceutically acceptable salts thereof.