Patent ID: 7166458

Claim:
An analyte sensing device for sensing a concentration of analyte in a fluid, the analyte sensing device comprising: a housing; and an analyte sensing component disposed within the housing and including: a first radiation converting component to convert radiation of a first wavelength to radiation having at least one different wavelength by receiving radiation of the first wavelength and, in response thereto, emitting radiation having at least one wavelength that is different from the first wavelength, wherein an efficiency of conversion by the first radiation converting component to radiation having at least one wavelength that is different from the first wavelength is dependent on the concentration of the analyte in the housing; a second radiation converting component to convert radiation of a second wavelength to radiation having at least one wavelength that is different from the second wavelength by receiving radiation of the second wavelength and, in response thereto, emitting radiation having at least one wavelength that is different from the second wavelength, wherein an efficiency of conversion of the radiation of the second wavelength by the second radiation converting component is independent or substantially independent of the concentration of the analyte in the housing; a plurality of beads or particles, wherein the second radiation converting component is embedded in or attached to at least one of the plurality of beads or particles; an analyte-specific binding ligand; and a macroporous matrix wherein (i) the analyte-specific binding ligand is attached to the macroporous matrix, and (ii) the plurality of beads or particles is embedded in the macroporous matrix.