Patent ID: 8158794

Claim:
A compound of Formula I: wherein: n is 1 or 2; R 1 is selected from the group consisting of: —R 4 , —X—R 4 , —X—Y—R 4 , and —X—R 5 ; R 3 is selected from the group consisting of: —Z—Ar, —Z—Ar′—Y—R 4 , and —Z—Ar′—X—Y—R 4 ; Ar is selected from the group consisting of aryl and heteroaryl both of which can be unsubstituted or can be substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, carboxy, formyl, amino, alkylamino, and dialkylamino; Ar′ is selected from the group consisting of arylene and heteroarylene both of which can be unsubstituted or can be substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, carboxy, formyl, amino, alkylamino, and dialkylamino; X is alkylene optionally interrupted by one —O— group; Y is selected from the group consisting of: —O—, —C(R 6 )—, —C(R 6 )—N(R 8 )—, —S(O) 0-2 —, —N(R 8 )-Q-, Z is selected from the group consisting of a bond and alkylene; R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, arylalkylenyl, heteroaryl, heteroarylalkylenyl, and heterocyclyl, wherein the alkyl, alkenyl, aryl, arylalkylenyl, heteroaryl, heteroarylalkylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclyl, amino, alkylamino, dialkylamino, and, in the case of alkyl, alkenyl, and heterocyclyl, oxo; R 5 is selected from the group consisting of: R 6 is selected from the group consisting of ═O and ═S; R 7 is C 2-7 alkylene; R 8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, hydroxyalkylenyl, arylalkylenyl, and heteroarylalkylenyl; R 10 is C 3-8 alkylene; A is selected from the group consisting of —O—, —C(O)—, —CH 2 —, —S(O) 0-2 —, and —N(Q-R 4 )—; Q is selected from the group consisting of a bond, —C(R 6 )—, —S(O) 2 , —C(R 6 )—N(R 8 )—, —S(O) 2 —N(R 8 )—, —C(R 6 )—O—, and —C(R 6 )—S—; and a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7; or a pharmaceutically acceptable salt thereof.