Patent ID: 7557114

Claim:
A compound of formula I wherein R 1 is halogen, —OR 1′ , —SR 1″ , morpholin, heterocycloalkyl, aryl or 5-or 6-membered heteroaryl; R 1′ and R 1″ are each independently hydrogen, lower alkyl, lower alkyl substituted by halogen, —(CH 2 ) x -cycloalkyl or —(CH 2 ) x -aryl; R 2 is —S(O) 2 -lower alkyl, —S(O) 2 NH-lower alkyl, or CN; is an aromatic or partially aromatic bicyclic amine, having one or two additional N-atoms selected from the group consisting of and wherein one additional N-ring atom of the aromatic or partially aromatic bicyclic amine can be available in form of its oxide R 3 to R 10 are each independently hydrogen, hydroxy, halogen, ═O, lower alkyl, cycloalkyl, heterocycloalkyl, lower alkoxy, CN, NO 2 , NH 2 , aryl, 5- or 6-membered heteroaryl containing one, two or three heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen, —NH-lower alkyl, —N(lower alkyl) 2 , cyclic amide, —C(O)-cyclic amide, S-lower alkyl, —S(O) 2 -lower alkyl, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, lower alkyl substituted by hydroxy, —O—(CH 2 ) y -lower alkoxy, —O(CH 2 ) y C(O)N(lower alkyl) 2 , —C(O)-lower alkyl, —O—(CH 2 ) x -aryl, —O—(CH 2 ) x -cycloalkyl, —O—(CH 2 ) x -heterocycloalkyl, —C(O)O-lower alkyl, —C(O)—NH-lower alkyl, —C(O)—N(lower alkyl) 2 , 2-oxy-5-aza-bicyclo[2.2.1]hept-5-yl or 3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl; R and R′, are each independently hydrogen or lower alkyl; wherein heteroaryl is selected from the group consisting of furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, thiazolyl, isothiazolyl, isoxazolyl, pyridinyl, pyrazinyl, and pyrimidinyl; and heterocycloalkyl is selected from the group consisting of tetrahydropyran-2, 3 or 4-yl, tetrahydrofuran-2 or 3-yl, oxetan-3-yl, and [1,4]dioxin-2-yl; and wherein all aryl-, morpholin, heterocycloalkyl- or 5 or 6 membered heteroaryl groups as defined for R 1 , R 1′ , R 1″ and R 3 to R 10 are unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxy, ═O, halogen, lower alkyl, phenyl, lower alkyl substituted by halogen and lower alkoxy; n, m, o, p, q, r, s and t are each independently 1 or 2; x is 0, 1 or 2; and y is 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.