Patent ID: 8895747

Claim:
A method for synthesis of an N-substituted pyridinium compound comprising the steps of: a) providing a Zincke salt according to any of following Formulas (IV)-(VII) and having at least one counter ion, selected from the group consisting of: Cl, Br, Tosylate, Mesylate, and Triflate: wherein X is O or S, R1 is methyl, ethyl, O-methyl, O-ethyl, NH 2 , N-dimethyl, N-diethyl, and R2 is NH 2 ; wherein X is O or S, R1 is methyl, ethyl, O-methyl, O-ethyl, NH 2 , N-dimethyl, N-diethyl, and R2 is NH 2 or Cl; wherein X is O or S, R1 is methyl, ethyl, O-methyl, O-ethyl, NH 2 , N-dimethyl, N-diethyl, and R2 and R3 independently are O—C1-C3 alkyl or NH 2 ; wherein X is O or S, R1 is methyl, ethyl, O-methyl, O-ethyl, NH 2 , N-dimethyl, N-diethyl, and R2 and R3 independently are O—C1-C3 alkyl and R7=H or Cl; b) reacting the Zincke salt of step (a) with a primary amine of Formula II: wherein the primary amine of Formula II is selected from the group consisting of: an alkyl amine, an alkyenyl amine, a heterocycloalkyl amine, an aryl amine, a heteroaryl amine, an amino alcohol, an amino acid, a furanoxylamine, or a cyclopentylamine, c) obtaining, an N-substituted pyridinium compound of Formula III: having a counter ion, wherein X is O or S, R1, is methyl, ethyl, O-methyl, O-ethyl, NH 2 , N-dimethyl, N-diethyl; and R6 is selected from the group consisting of: alkyl, alkyenyl, heterocycloalkyl, aryl, heteroaryl, hydroxyalkyl, carboxylic acid, a furanoxyl, or cyclopentyl.