Patent ID: 7119214

Claim:
A compound of formula (A): wherein: Ar is: wherein: U is O or S; rings A and B are optionally substituted with one to three groups selected from F, cl, Br, I, OR 22 , OR 27 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, 3–7 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, arylalkyl, C(═O)R 22 , CO 2 R 22 , OC(═O)R 22 , C(═O)NR 23 R 24 , NR 21 C(═O)R 22 , NR 21 CO 2 R 22 , OC(═O)NR 23 R 24 , NR 21 C(═S)R 22 , and S(O) y R 22 ; Y is C 1 –C 6 alkylene; wherein said alkylene groups are optionally substituted with one to three R 20 groups; R 1 is C(═O)NR 12 R 13 , R 12 and R 13 at each occurrence are each independently selected from H, C 1 –C 6 alkyl, or R 12 and R 13 , together with the nitrogen to which they are attached, form a 3–7 membered heterocyclic ring; wherein said alkyl groups and heterocyclic ring are optionally substituted with one to three R 20 groups; R 20 at each occurrence is independently selected from F, Cl, Br, I, OR 22 , OR 27 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 –C 6 alkyl optionally substituted with OH, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, 3–7 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, arylalkyl, ═O, C(═O)R 22 , CO 2 R 22 , OC(═O)R 22 , C(═O)NR 23 R 24 , NR 21 C(═O)R 22 , NR 21 C(═O)OR 22 , OC(═O)NR 23 R 24 , NR 21 C(═S)R 22 , and S(O) y R 22 ; R 21 at each occurrence is independently selected from H and C 1 –C 6 alkyl; R 22 at each occurrence is independently selected from H, C 1 –C 6 alkyl optionally substituted with OH, arylalkyl and C 6 –C 10 aryl; R 23 and R 24 at each occurrence are each independently selected from H, C 1 –C 6 alkyl, and C 6 –C 10 aryl, or R 23 and R 24 , together with the nitrogen to which they are attached, form a 3–7 membered heterocyclic ring optionally substituted with ═O; R 27 at each occurrence is independently the residue of an naturally occurred amino acid after the hydroxyl group of the carboxyl group is removed; q is 1, or 2; y is 0, 1, or 2; and the stereoisomeric forms, mixtures of stereoisomeric forms or pharmaceutically acceptable salts forms thereof.