Patent ID: 7939524

Claim:
A compound of Formula I wherein X is N, A is Ring B is 6-membered aryl, optionally substituted by 1-3 R 1 moieties, wherein is R 1 is H, halo, nitro, —CHR 4 —S(O) 2 R 5 , —C(S(O) 2 R 5 )═CHR 4 —, —NR 5 R 6 , —NR 4 S(O) 2 R 5 , or —NR 4 S(O) 2 NR 5 R 6 , wherein R 4 , R 5 , and R 6 are independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C(O)O—(C 1 -C 6 alkyl), aryl, or heterocyclyl, or R 4 and R 5 or R 5 and R 6 combine with the atom(s) to which they are attached to form a 5- or 6-membered heterocyclyl ring, R 2 is H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, —C 1 -C 6 alkylene(C 3 -C 8 cycloalkyl), —C 1 -C 6 alkylene(aryl), —C 1 -C 6 alkylene(heterocyclyl), aryl, or heterocyclyl, Z is —(CR 13 R 14 ) n —, or O, n is 1 or 2, R 7 and R 8 are independently H or C 1 -C 6 alkyl, R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , and R 16 are independently H, C 1 -C 6 alkyl, hydroxy, or halo, wherein the above alkyl, alkylene, aryl, cycloalkyl, or heterocyclyl moieties provided in R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , and R 16 are each optionally and independently substituted by 1-3 substituents selected from alkylamine, amino, aryl, cycloalkyl, heterocyclyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms, carboxyl, cyano, halo, hydroxy, keto, nitro, —C(O)OH, —C(O)NH 2 , —C(O)(C 1 -C 6 alkylamine), —C(O)(C 1 -C 6 dialkylamine), —C(O) 2 —(C 1 -C 6 alkyl), —C(O) 2 —(C 3 -C 8 cycloalkyl), —C(O) 2 -(aryl), —C(O) 2 -(heterocyclyl), —C(O) 2 —(C 1 -C 6 alkylene)aryl, —C(O) 2 —(C 1 -C 6 alkylene)heterocyclyl, —C(O) 2 —(C 1 -C 6 alkylene)cycloalkyl, —C(O)(C 1 -C 6 alkyl), —C(O)(C 3 -C 8 cycloalkyl), —C(O)(aryl), —C(O)(heterocyclyl), —C(O)(C 1 -C 6 alkylene)aryl, —C(O)(C 1 -C 6 alkylene)heterocyclyl, and —C(O)(C 1 -C 6 alkylene)cycloalkyl, wherein each of the above optional substituents can be further optionally substituted by 1-5 substituents selected from amino, cyano, halo, hydroxy, nitro, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkenyl, and C 1 -C 6 hydroxyalkyl, wherein each alkyl is optionally substituted by one or more halo substituents, or a pharmaceutically acceptable salt or stereoisomer thereof.