Patent ID: 7097849

Claim:
A composition comprising a stable, sterile, and injectable aqueous dispersion of a water-insoluble microdroplet matrix of mean diameter from about 50 nm to about 1000 nm, the dispersion consisting essentially of (a) between about 1% to about 15% of propofol; (b) between about 1% to about 4% of a propofol soluble diluent selected from a medium chain triglyceride comprising medium chain fatty acids of synthetic or natural origin, or mixtures of said medium chain triglycerides; (c) between about 0.5% to about 5% of one or more surface stabilizing amphiphilic agents; and (d) from about 2.5% to about 20% of a pharmaceutically acceptable water-soluble polyhydroxy additive that acts as a tonicity modifier; and (e) water; wherein the ratio of propofol to diluent is about 1:4 to about 1:0.1 and the ratio of propofol to amphiphilic agent is about 1:0.8 to about 1:2.5, and the composition has a viscosity of greater than about 1.2 centipoise, and further wherein the dispersion inhibits microbial growth, is non-irritating at the site of injection and decreases hemolytic potential.