Patent ID: 7767879

Claim:
A transgenic mouse produced by: (a) crossing a first transgenic mouse whose genome comprises a transgene comprising a nucleotide sequence operably linked to a Syrian hamster prion protein gene promoter and encoding a human amyloid precursor protein 695 (APP695) polypeptide wherein the lysine residue at position 670 is substituted by asparagine, the methionine residue at position 671 is substituted by leucine and the valine residue at position 717 is substituted by phenylalanine, and wherein the transgene is expressed, with a second mouse having a genome comprising a second gene comprising a nucleotide sequence operably linked to a promoter and encoding a selected protein having at least one selected mutation, and wherein the gene is expressed, to produce first generation offspring; and (b) selecting from the first generation offspring a transgenic mouse having a genome comprising at least one first transgene comprising a nucleotide sequence operably linked to a Syrian hamster prion protein gene promoter and encoding a human APP695 polypeptide wherein the lysine residue at position 670 is substituted by asparagine, the methionine residue at position 671 is substituted by leucine and the valine residue at position 717 is substituted by phenylalanine, and at least one second gene comprising a nucleotide sequence operably linked to a promoter and encoding said selected protein having at least one selected mutation, wherein at least both the first transgene and the second gene are expressed and expressing both said at least one first transgene and said at least one second gene.