Patent ID: 7785577

Claim:
Method for the cosmetic treatment of canities comprising the administration to a patient in need thereof of an effective amount of a peptide of formula (I) W-DPhe-Arg-Z (I) or its peptidic conjugate of formula (II) A-W-DPhe-Arg-Z (II) wherein: A represents a radical corresponding to a monocarboxylic acid of general formula (III) HOOC—R (III) wherein R represents a linear or branched aliphatic C 1 -C 24 radical, possibly substituted with a hydroxy group, and which may contain one or several unsaturations. lipoic acid or its reduced form dihydrolipoic acid, N-lipoyl-lysine or phenylbutyric acid W represents His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg, Nle-Ala-Arg, Nle-Ala-DTrp or a bond in the case of peptidic conjugates of formula II Z represents NH 2 , OH, OR1 wherein R1 represents a linear or branched aliphatic C 1 -C 24 radical, TrpNH 2 , NapNH 2 , TpiNH 2 , TicNH 2 , AlaNH 2 , TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH 2 or PheOH with the exception of a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z represents Trp NH 2 , in the form of enantiomers or diastereoisomers as well as mixtures thereof, including racemic mixtures, and wherein the peptide of formula (I) and peptidic conjugate of formula (II) each contains at most six amino acids.