Patent ID: 8367684

Claim:
A compound of formula IA-1a wherein R 5 is C 3 -C 6 alkyl or CH 2 —C 3 —C 6 -cycloalkyl and where R 5 is optionally substituted with halogen, hydroxy, or methoxy; at least one of W and Z is N, and the other is C; R 1 is H, CN, halogen, CH 2 CN, OH, NO 2 , CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , C 1 -C 6 alkyl, C(═O)C 1 -C 6 alkyl, NH—C 1 -C 6 alkyl, NHC(═O)C 1 -C 6 alkyl, C(═O)N(CH 3 ) 2 , C(═O)N(Et) 2 , C(═O)NH—C 1 -C 6 alkyl, C(═O)OC 1 -C 6 alkyl, OC(═O)C 1 -C 6 alkyl, OC 1 -C 6 alkyl, SC 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, (CH 2 ) m C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl, (CH 2 ) m C 3 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Ar 1 , (CH 2 ) m Ar 1 , phenyl, pyridyl, pyrrolyl, (CH 2 ) m imidazolyl, (CH 2 ) m pyrazyl, furyl, thienyl, (CH 2 ) m oxazolyl, (CH 2 ) m isoxazolyl, (CH 2 ) m thiazolyl, (CH 2 ) m isothiazolyl, (CH 2 ) m phenyl, (CH 2 ) m pyrrolyl, (CH 2 ) m pyridyl, or (CH 2 ) m pyrimidyl, which cycloalkyl and said cycloalkenyl groups optionally contain one or two heteroatoms selected independently from O, N, and S, and which alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, imidazolyl, pyrazyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, phenyl, pyrrolyl, pyridyl, or pyrimidyl groups are optionally substituted with one or two groups selected, independently, from OH, halogen, cyano, methyl, ethyl, or trifluoromethyl, where m is zero, 1, or 2; R 3 and R 4 are, independently, H, halogen, methyl, methoxy, or trifluoromethyl; R′ and R 2 are, independently, H, halogen, methyl, or trifluoromethyl; and pharmaceutically acceptable salts thereof.