Patent ID: 7105549

Claim:
A compound having the Formula II: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: R 1 is selected from the group consisting of an optionally substituted alkyl, amino, alkylthiol, C(O)R 10 , SO 2 R 10 , OC(O)NH 2 , 2-imidazolinyl, 2-imidazolyl, 3-pyrazolyl, 5-isoxazolyl, and 3-(1,2,4)-triazolyl; R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, alkenyl, or alkynyl, halogen, hydroxy, cycloalkyl, cyano, amino, alkylamino, dialkylamino, alkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, and aralkylcarbonylamino; provided that the pyridyl ring is other than 2,6-disubstituted with regard to the aryl radical and R 1 or any of R 2 –R 4 that is other than hydrogen; R 5 , R 6 , R 7 , and R 8 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido and alkylthiol; and R 10 is selected from the group consisting of alkyl, alkenyl, alkynyl, OR 11 , amino, alkylamino, dialkylamino, alkenylamino, dialkylaminoalkenyl, dialkylaminoalkylamino, dialkylaminoalkenylamino, alkylaminoalkenyl-amino, hydroxyaminoalkenylamino, cycloalkyl, heterocycloalkyl, cycloalkylalkylamino, heterocycloalkylamino, aryl, arylalkyl, arylalkenyl, arylalkynyl, and arylalkylamino, all of which can be optionally substituted, provided that R 10 is not OR 11 when R 1 is SO 2 R 10 ; wherein R 11 is selected from the group consisting of hydrogen, optionally substituted alkyl, and an alkali metal; and X is one of O, S, NH, or CH 2 ; with the proviso that when X is O, R 5 , R 6 and R 7 are each hydrogen, and R 1 is an alkyl group, then R 8 is other than an optionally substituted alkoxy group.