Patent ID: 8293206

Claim:
A polyfunctional compound of the Formula I: wherein: A is a low molecular weight scaffold being at least one member of the group consisting of: functionalized monocyclic and polycyclic hydrocarbons, functionalized monocyclic and polycyclic heterocycles, an amino acid residue, linear peptides, cyclic peptides, synthetic peptides, semisynthetic peptides, peptidomimetics and hyaluronic acid, and derivatives thereof; each L 1 , L 2 and L 3 is independently a bond, or a linker being at least one member of the group consisting of: an amino acid residue, —O—,—S—,—S(O)—, —S(O) 2 —, —NR a —, C 1-6 alkyl, (CH 2 CH 2 O) 1-15 , wherein R a is at least one member of the group consisting of: H, C 1-5 alkyl, heterocyclyl, aryl, or heteroaryl, and wherein 1 or 2 carbon atoms of the C 1-6 alkyl is replaced by at least one of —O—,—C(O)—, —C(O)NR′—, —S—, —S(O)—, —S(O) 2 —, —S(O) 2 NR′— or —NR′— where R′ is H or C 1-5 alkyl, and where the C 1-6 alkyl is optionally substituted with 1 or 2 substituents selected from the group consisting of —OH, —SH, —NH 2 , heterocyclyl, aryl and heteroaryl; V is —N 3 or C 2 -C 4 alkynyl; X is an activated moiety of a carboxyl group; Y is an electrophilic group; and each m, n and p is independently an integer of 1 to 10; or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixtures of stereoisomers thereof.