Patent ID: 7893260

Claim:
A method for treating or alleviating acute or chronic pain in an animal by inhibiting a TRPV3 mediated current in the animal, comprising the step of administering to the animal an effective amount of a compound of Formula I or a salt thereof: wherein Ar represents phenyl or pyridyl, each optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, lower cycloalkyl, halogen, thiocarbonyl, acyl, formyl, hydroxy, alkoxy, acyloxy, amino, acylamino, amido, alkylsulfonyl, sulfamoyl, alkylsulfonamido, cyano, nitro, alkylthio, azido, —NHSO 2 NH 2 , and —NHSO 2 CH 3 , wherein said alkyl, alkenyl, alkynyl, lower cycloalkyl, thiocarbonyl, acyl, alkoxy, acyloxy, amino, acylamino, amido, alkylsulfonyl, sulfamoyl, alkylsufoamido, and alkylthio are each optionally substituted with one or more substituents selected from the group consisting of halogen, acyl, thiocarbonyl, amino, acylamino, amido, amidino, cyano, nitro, azido, sulfonyl, sulfoxido, sulfate, sulfonate, sulfamoyl, sulfonamido, and phosphoryl; Ar′ represents phenyl or pyridyl, each optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, lower cycloalkyl, halogen, thiocarbonyl, acyl, formyl, hydroxy, alkoxy, acyloxy, amino, acylamino, amido, alkylsulfonyl, sulfamoyl, alkylsulfonamido, cyano, nitro, alkylthio, —NHSO 2 NH 2 , —OCH 2 CH 2 NHR 7 , and azido, wherein said alkyl, alkenyl, alkynyl, lower cycloalkyl, thiocarbonyl, acyl, alkoxy, acyloxy, amino, acylamino, amido, alkylsulfonyl, sulfamoyl, alkylsufoamido, and alkylthio are each optionally substituted with one or more substituents selected from the group consisting of halogen, acyl, thiocarbonyl, amino, acylamino, amido, amidino, cyano, nitro, azido, sulfonyl, sulfoxido, sulfate, sulfonate, sulfamoyl, sulfonamido, and phosphoryl; R 7 is lower alkyl; G1 and G2, together with the carbons to which they are attached, form a phenyl group fused to the pyrimidinone ring wherein the phenyl group is optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, carboxyl, ester, acyl, amido, sulfonamide, heterocyclyl, cycloalkyl, hydroxyl, amino, acylamino, thioether, sulfonylamino, nitro, halogen, trifluoromethyl, cyano, and —NHSO 2 NH 2 ; and L represents cis- or trans-ethene.