Patent ID: 8614065

Claim:
A method for detecting in vivo or in vitro the presence of EGFR in a sample comprising: (a) contacting a sample to be tested, optionally with a control sample, with an antigen binding molecule (ABM) that specifically binds EGFR under conditions that allow for formation of a complex between the ABM and EGFR; and (b) detecting the ABM-EGFR complexes; wherein the ABM comprises a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain comprises: (1) a CDR1 selected from the group consisting of: SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:123, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:71, SEQ ID NO:73, and SEQ ID NO:125; (2) the CDR2 of SEQ ID NO:79; (3) the CDR3 of SEQ ID NO:107; and wherein the light chain variable domain comprises: (1) the CDR1 of SEQ ID NO:111 or SEQ ID NO:113; (2) the CDR2 of SEQ ID NO:115; and (3) the CDR3 of SEQ ID NO:117.