Patent ID: 8071781

Claim:
A process for preparing rabeprazole sodium comprising the steps of: (a) contacting rabeprazole sodium compound with a solvent system to thereby obtain a clear solution under a first temperature ranging from 25 to 50, wherein said solvent system is a mixture comprising a ketone solvent and a cyclic hydrocarbon solvent, a mixture comprising a ketone solvent and an ether solvent, or a mixture comprising a heterocyclic organic solvent and a cyclic hydrocarbon solvent, and wherein: when said solvent system is the mixture comprising the ketone solvent and the cyclic hydrocarbon solvent, and the cyclic hydrocarbon solvent is present in a vol/vol ratio of the cyclic hydrocarbon solvent to the ketone solvent of 0.3 to 5; when said solvent system is the mixture comprising the ketone solvent and the ether solvent, and the ketone solvent is present in a vol/vol ratio of the ketone solvent to the ether solvent of 1.5 to 5; and when said solvent system is the mixture comprising the heterocyclic organic solvent and the cyclic hydrocarbon solvent, and the cyclic hydrocarbon solvent is present in a vol/vol ratio of the cyclic hydrocarbon solvent to the heterocyclic organic solvent of 0.2 to 5; (b) stirring said clear solution of step (a) under a second temperature for more than 3 hours to obtain a solution containing resultant separated solid, wherein said second temperature ranges from 25 to 50; (c) filtering said solution containing resultant separated solid obtained from step (b) to obtain a wet solid; and (d) drying said wet solid to obtain an amorphous rabeprazole sodium compound.