Patent ID: 8067186

Claim:
A method of identifying a competing antibody selected from the group consisting of: (i) an antibody that specifically binds to the same epitope on a cell expressing a CA6 antigen that is bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449 or the same epitope on a CA6 antigen that is bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449, and (ii) an antigen-binding fragment of the antibody of (i) that specifically binds to the same epitope on a cell expressing a CA6 antigen that is bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449 or the same epitope on a CA6 antigen that is bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449, the method comprising: (a) contacting the antibody and labeled monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449 with a cell expressing a CA6 antigen containing an epitope specifically bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449 or with a CA6 antigen containing the same epitope bound by a monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449; and (b) determining if the antibody competes with the labeled monoclonal antibody produced by the hybridoma cell line DS6 deposited with the American Type Culture Collection as deposit number PTA-4449 for binding to the epitope on the cell expressing the CA6 antigen or to the epitope on the CA6 antigen.