Patent ID: 7439374

Claim:
A compound of Formula 1 or a pharmaceutically acceptable salt thereof, wherein V is C 1 -C 4 alkyl or absent; A 1 is Nitrogen or CR 1 ; A 2 is Nitrogen or CR 2 ; A 3 is Nitrogen or CR 3 ; A 4 is Nitrogen or CR 4 ; where only 1 of A 1 , A 2 , A 3 , or A 4 is Nitrogen; 1 of R 1 -R 4 , is chosen from: hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, and mono- and di-(C 1 -C 6 alkyl)amino; and the remaining R 1 -R 4 are all hydrogen; R 5 is hydrogen or C 1 -C 4 alkoxy; R 6 and R 7 are independently hydrogen or C 1 -C 6 alkyl; and Ar is an aryl or heteroaryl, each of which is substituted with 0 to 5 substituents independently chosen from: (i) halogen, hydroxy, cyano, nitro, oxo, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, and (ii) C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 alkoxy, C 2 -C 8 alkenyloxy, mono- and di-(C 1 -C 8 alkyl)amino, mono- and di-(C 1 -C 4 alkyl)aminoC 1 -C 4 alkyl, C 2 -C 8 alkanoyl, C 2 -C 8 alkanoyloxy, C 1 -C 8 alkoxycarbonyl, mono- and di-(C 1 -C 8 alkyl)carboxamide, (C 3 -C 7 cycloalkyl)carboxamide, and C 1 -C 8 alkylthio, and (iii) -GR a where G is chosen from —(CH 2 ) n —, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, —O(C═O)—, and —(CH 2 ) n O(CH 2 ) m —, —(CH 2 ) n N(CH 2 ) m —, where n and m are independently 0, 1, 2, 3, or 4; and R a is chosen from C 3 -C 8 cycloalkyl, C 2 -C 7 monocyclic heterocycloalkyl, mono-unsaturated 5- to 7-membered heterocyclic rings, 9- to 10-membered bicyclic carbocyclic groups, 9- to 10-membered bicyclic heterocyclic groups containing 1 nitrogen atom, aryl, and heteroaryl; each of which (ii) and (iii) is substituted with 0 to 5 substituents independently chosen from halogen, hydroxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and phenyl.