Patent ID: RE40359

Claim:
A bioerodable construct for controlled release of bioactive materials, said construct comprising a blend of at least two poly(ester-amide) polymers (PEA) prepared by polymerizing a diol (D), wherein the diol (D) is not bisphenol; a dicarboxylic acid (C) , wherein the dicarboxylic acid (C) is not phthalic acid; and an alpha-amino acid (A) through ester and amide links in the form (DACA) n . , wherein the PEA polymer has the formula: wherein k= 2 - 12 , m= 2 - 12 , and R=CH 2 CH(CH 3 ) 2 , or CH 2 C 6 H 5 . and, wherein the blend comprises a first PEA polymer in which A is phenylalanine (Phe-PEA) and a second PEA polymer in which A is leucine (Leu-PEA) at a ratio of Phe-PEA to Leu-PEA is from of 10:1 to 1:1.