Patent ID: 8084479

Claim:
A method for inhibiting PKB in a mammal in need thereof, comprising: administering to the mammal a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt, stereoisomer, or mixture thereof, wherein the compound of Formula I has the following structure: wherein: A is Y is —N(R 5 )R 6 ; X is —N(R 7 ); R 1 is R 8 , —CHR 11 —N(H)—R 8 , —CHR 11 —O—R 8 , C 2 -C 6 alkynyl, C 2 -C 6 hydroxyalkynyl, or —C≡N; R 2 is unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R 3 is —H, or unsubstituted C 1 -C 6 alkyl; R 4 is a —(CR 9 R 10 ) t (aryl) or —(CR 9 R 10 ) t (heteroaryl); R 5 is —H, C 1 -C 8 alkyl, —C(O)(CR 9 R 10 ) t )N(R 7 ) 2 , —(CR 9 R 10 ) t (aryl), —(CR 9 R 10 ) t (heteroaryl), —(CR 9 R 10 ) t (cycloalkyl), or —(CR 9 R 10 ) t (heterocyclyl); R 6 and R 7 are independently selected from —H, C 1 -C 8 alkyl, —(C 1 -C 6 alkyl)aryl, or —C(O)(C 1 -C 6 alkyl), or R 5 and R 6 , together with the nitrogen atom to which they are linked, join to form a 5 to 6-membered heterocyclic or heteroaryl ring; R 8 is —H, C 1 -C 6 alkyl, —(C 1 -C 6 alkyl)aryl, aryl, or heteroaryl; and R 9 , R 10 , and R 11 are independently selected from —H, C 1 -C 6 alkyl, or aryl; wherein n is 1; m is 1; and t is 1; wherein each of the above alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl moieties and heterocyclic and carbocyclic rings are optionally and independently substituted by 1-3 substituents selected from amino, aryl, heteroaryl, cycloalkyl, or heterocyclyl optionally substituted by 1-5 substituents selected from C 1 -C 6 alkoxy, C 1 -C 6 alkyl optionally substituted by halo, aryl, halo, hydroxyl, heteroaryl, C 1 -C 6 hydroxyalkyl, or —NHS(O) 2 —(C 1 -C 6 alkyl); C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylamino, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms, cyano, halo, hydroxyl, nitro, or —O-aryl.