Patent ID: 8598164

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence and optionally substituted, as valency allows, with one or more substituents selected from the group consisting of halo, cyano, oxoalkoxy, hydroxy, amino, nitro, aryl, haloalkyl, and alkyl: R 1 is C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, halo, CN, OH, OR 7 , N(R 7 ) 2 , NR 7 SO 2 R 7 , SO 2 R 7 , SR 7 , SOR 7 , CO 2 R 7 , NR 7 COR 7 , NR 7 CO 2 R 7 , CON(R 7 ) 2 , SO 2 N(R 7 ) 2 , CF 3 , OCF 3 , OCHF 2 , heterocycloalkyl, aryl, heteroaryl or (C1-C6)-R 8 wherein up to two CH 2 units may be replaced with O, CO, S, SO, SO 2 , NR 7 ; R 2 is H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, halo, aryl, an electron withdrawing group, CH 2 CF 3 , CHF 2 , CF 3 , CN, OH, OR 7 , CON(R 7 ) 2 , SO 2 R 7 , SR 7 , SOR 7 , SO 2 N(R 7 ) 2 , or (C1-C6)-R 8 wherein up to two CH 2 units may be replaced with O, CO, S, SO, SO 2 , CF 2 , or NR 7 ; R 3 is halo, C1-C6 alkyl or C3-C8 cycloalkyl, wherein up to two CH 2 units may be replaced by O, CO, S, SO, SO 2 , or NR 8 , or 2 occurrences of R 3 taken together form a C3-C8 cycloalkyl group; R 7 is H, C1-C6 alkyl, CHF 2 , CF 3 , or C3-C8 cycloalkyl, or 2 R 7 taken together with the atoms to which they are attached form a heterocyclic or heteroaromatic ring; R 8 is H, CF 3 , CO 2 R 7 , OH, aryl, heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, N(R 7 ) 2 , NR 7 COR 7 , CON(R 7 ) 2 , CN, or SO 2 R 7 ; A is aryl, heteroaryl or heterocyclic; X is N, S, or CR 2 wherein at least one X is N; W is N or CH, wherein up to 2 W are N; a - - - - line denotes an optionally double bond depending on the identity of X; m is an integer from 0 to 4 inclusive; n is an integer from 0 to 3 inclusive; and o is an integer from 0 to 4 inclusive.