Patent ID: 7915420

Claim:
A compound of the formula: wherein R 1 is H or is a substituted or unsubstituted C 1-5 alkyl, C 1-5 alkenyl, or C 1-5 alkynyl; R 2 and R 3 are taken together with the nitrogen of attachment to form piperidinyl, pyrrolidinyl, pyrrolinyl, tetrahydropyridinyl, dihydropyridinyl, azepanyl or morpholinyl, wherein each R 2 and R 3 substituent taken together, is optionally substituted with hydroxy or C 1-4 alkoxy; R 4 is phenyl optionally substituted at the 2 or 3 position with one or two R q ; Ar 1 is thiophenediyl optionally substituted with R q ; Y 1 and Y 2 are independently selected from a methylene or a ethylene; X is S, O, or is NR 1 , or alternatively, is a covalent bond; and R q is selected from the group consisting of —OH, —C 1-6 alkyl, —OC 1-6 alkyl, -Ph, -PhOH, -ureaPh, —OPh, benzyl, —Obenzyl, -ureabenzyl, thiophenyl, —C 3-6 cycloalkyl, —OC 3-6 cycloalkyl, —CN, —NO 2 , —N(R y )R z wherein R y and R z are independently selected from the group consisting of H, C 1-6 alkyl and C 1-6 alkenyl, —(N—R t )COR t , —(N—R t )SO 2 C 1-6 alkyl wherein R t is independently H or C 1-6 alkyl —(C═O)C 1-6 alkyl, —(S═(O) n )—C 1-6 alkyl wherein n is selected from 0, 1 or 2, —SO 2 N(R y )R z , —SCF 3 , halo, —CF 3 , —OCF 3 , —COOH and —COOC 1-6 alkyl; and stereoisomers and pharmaceutically acceptable salts thereof.