Patent ID: 7368452

Claim:
A method of inhibiting the replication of hepatitis C virus, the method comprising supplying a hepatitis C viral NS3 protease inhibitory amount of the pharmaceutical composition comprising a compound of Formula I or II: Wherein A is independently selected from hydrogen; —(C═O)—O—R 1 , —(C═O)—R 2 , —C(═O)—NH—R 2 , —C(═S)—NH—R 2 , —S(O) 2 —R 2 ; G is independently selected from —OH, —O—(C 1 -C 12 alkyl), —NHS(O) 2 —R 1 , —(C═O)—R 2 , —(C═O)—O—R 1 , or —(C═O)—NH—R 2 ; L is absent or independently selected from —S—, —SCH 2 —, —SCH 2 CH 2 —, —S(O) 2 —, —S(O) 2 CH 2 CH 2 —, —S(O)—, —S(O)CH 2 CH 2 —, —O—, —OCH 2 —, —OCH 2 CH 2 —, —(C═O)—CH 2 —, —CH(CH 3 )CH 2 —, —CFHCH 2 —, or —CF 2 CH 2 —; X and Y taken together with the carbon atoms to which they are attached form a cyclic moiety selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; W is absent, or independently selected from —O—, —S—, —NH—, or —NR 1 —; Z is independently selected from hydrogen, —CN, —SCN, —NCO, —NCS, —NHNH 2 , —N 3 , halogen, —R 4 , —C 3 -C 12 cycloalkyl, substituted —C 3 -C 12 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, and substituted heterocycloalkyl and —NH—N═CH(R 1 ); wherein R 1 is independently selected from hydrogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, substituted C 1 -C 6 alkynyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; wherein R 2 is independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, substituted C 1 -C 6 alkynyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, alkylamino, dialkylamino, arylamino, diarylamino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; wherein R 4 is independently selected from: (i) —C 1 -C 6 alkyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, (ii) —C 2 -C 6 alkenyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; (iii) —C 2 -C 6 alkynyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituent selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; R 5 and R 6 are each independently hydrogen or methyl j=0, 1, 2, 3, or 4; m=0, 1, or 2; and s=0, 1 or 2.