Patent ID: RE39464

Claim:
An oligomeric compound comprising a plurality of covalently-bound nucleosides; said compound having the formula: 5′-T 1 —(Nu—Sp) n —(Nu—Lp) m —(NU—Sp) p —Nu—T 2 -3′ wherein: T 1 and T 2 are each, independently, hydroxyl, a protected hydroxyl, a covalent attachment to a solid support, a nucleoside, an oligonucleoside, a nucleotide, an oligonucleotide, a conjugate group or a 5′ or 3′ substituent group; each Sp is a chiral Sp phosphorothioate internucleoside linkage; each Lp is, independently, a chiral Rp phosphorothioate internucleoside linkage, a racemic phosphorothioate internucleoside linkage or an internucleoside linkage other than a chiral phosphorothioate internucleoside linkage; each n and m is, independently, from 1 to 100; each p is from 0 to 100; where the sum of n, m and p is from 3 to about 200; each Nu independently, has the formula: wherein: Bx is a heterocyclic base moiety; and R 1 is H, hydroxyl, a protected hydroxyl, a 2′-substituent group or a protected 2′-substituent group.