Patent ID: 8260596

Claim:
A method for analyzing the three dimensional structure of a GPCR on a computer system, comprising: a) accessing a file containing atomic coordinates of a GPCR using a computer system that comprises a modeling program, wherein said atomic coordinates are produced by subjecting crystals of a GPCR fusion protein to X-ray diffraction analysis, wherein said GPCR fusion protein comprises, from N-terminus to C-terminus: i. a first portion of a G-protein coupled receptor (GPCR), wherein said first portion comprises TM1, TM2, TM3, TM4 and TM5 regions of said GPCR; ii. a domain comprising the amino acid sequence of a lysozyme; and iii. a second portion of said GPCR, wherein said second portion comprises TM6 and TM7 regions of said GPCR; b) modeling said atomic coordinates on said computer system using said modeling program to produce a model of the three dimensional structure of at least a portion of the GPCR; and c) displaying the model of said three dimensional structure on the computer system.