Patent ID: 8357688

Claim:
A compound of formula (I): wherein A 1 is N and A 2 is CR 6 , one of R 1 and R 2 is hydrogen; halogen; or lower alkyl, —O-lower alkyl, or cycloalkyl, each of which may be substituted with one or more substituents selected from the group consisting of —OH, —O-lower alkyl, —NH 2 , —NH-lower alkyl, —N(lower alkyl) 2 , and a monocyclic nitrogen-containing hetero ring which may be substituted with lower alkyl; and the other is a group of formula (II), R 3 is lower alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or a saturated hetero ring, each of which may be substituted with one or more substituents selected from the group consisting of halogen, lower alkyl, cycloalkyl, —OH, oxo, —O-lower alkyl, —COOH, —CO—O-lower alkyl, —CO—O-lower alkenyl, —CO—O-lower alkynyl, —CO—O-lower alkylene-O-lower alkyl, —CO—O-lower alkylene-aryl, —CO—O-lower alkylene-O-aryl, —CO—NH 2 , —CO—NH-lower alkyl, —CO—N(lower alkyl) 2 , —CO—N(lower alkyl)-aryl, —CO—N(lower alkyl)-(lower alkylene-aryl), —CO—NH-lower alkylene-OH, —CO—NH-lower alkylene-CO 2 H, and a monocyclic sulfur-containing saturated hetero ring, R 4 and R 5 are the same or different, and each is hydrogen or lower alkyl, R 6 is hydrogen or lower alkyl, and R a and R b are combined with the adjacent nitrogen atom to form a polycyclic nitrogen-containing hetero ring, which may be substituted with one or more substituents selected from the group consisting of halogen; —OH; oxo; —O-lower alkyl; cyano; nitro; halogeno-lower alkyl; cycloalkyl; aryl which may be further substituted with a group selected from a group G 1 ; a hetero ring which may be further substituted with a group selected from a group G 2 ; lower alkylene-(aryl which may be further substituted with a group selected from a group G 1 ); lower alkylene-SO 2 —NR 7 R 8 ; lower alkylene-hetero ring; lower alkyl which may be further substituted with —OH, —O-lower alkyl, cyano, or cycloalkyl; —COOH; —CO—O-lower alkyl; —CO—O-lower alkenyl; —CO—O-lower alkynyl; —CO—O-lower alkylene-O-lower alkyl; —CO—O-lower alkylene-aryl; —CO—O-lower alkylene-O-aryl; —CO—NH 2 ; —CO—NH-lower alkyl; —CO—N lower alkyl) 2 , —CO—N(lower alkyl)-aryl; —CO—N(lower alkyl)-(lower alkylene-aryl); —CO—NH-lower alkylene-OH; —CO—NH-lower alkylene-CO 2 H; —NH—SO 2 —R 9 ; —SO 2 —NR 7 R 8 ; and a monocyclic nitrogen-containing hetero ring, wherein R 7 and R 8 are the same or different, and each is hydrogen or lower alkyl, R 9 is lower alkyl, or aryl which may be substituted with lower alkyl; group G 1 contains halogen, lower alkyl, halogeno-lower alkyl, —OH, —O-lower alkyl, —O-lower alkylene-aryl, —O-lower alkylene-hetero ring, —O-halogeno-lower alkyl, aryl, and a hetero ring, and group G 2 contains halogen, lower alkyl, halogeno-lower alkyl, —OH, —O-lower alkyl, —O-lower alkylene-aryl, —O-lower alkylene-hetero ring, —O-halogeno-lower alkyl, aryl, and a hetero ring, or a pharmaceutically acceptable salt thereof.