Patent ID: 8889652

Claim:
A method for treating an arthritic disorder which comprises injecting, into an intra-articular area or a joint, a pharmaceutical composition in the form of an injectable solution of a cross-linked hyaluronate gel wherein a 1% solution of the hyaluronate capable of being extruded from a 23-gauge injection needle at 24° C. under a pressure of 5.0 Kg/cm 2 , comprising: (a) a cross-linked hyaluronic acid derivative wherein part of functional groups of hyaluronic acid are cross-linked to each other with a cross-linking group, said cross-linked hyaluronic acid derivative having following characteristics: (i) a cross-linking extent of functional groups of the hyaluronic acid is 1% to 7.5% based on a total number of constituent disaccharide units of the hyaluronic acid, (ii) the cross-linking group is a residue of cinnamic acid or a cinnamic acid derivative, (iii) a degree of substitution of a cross-linking group is from 10% to 25%, and (iv) a degree of cross-linking in the cross-linked hyaluronic acid derivative is from 10% to 30%, and (b) a pharmaceutically acceptable aqueous medium.