Patent ID: 7179892

Claim:
A humanized immunoglobulin which specifically binds to beta amyloid peptide (Aβ) with a binding affinity of at least 10 7 M −1 , or antigen binding fragment thereof, the humanized immunoglobulin or antigen binding fragment comprising: (a) a light chain comprising a variable light chain region comprising the complementarity determining regions (CDRs) and at least one variable light chain framework residue selected from the group consisting of L1, L2, L4, L15, L35, L36, L38, L44, L46, L47, L48, L49, L64, L66, L68, L69, L71, L83, L85, L87, and L98 (Kabat numbering convention) from the 3D6 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:2, wherein the remainder of the variable light chain region is from a human acceptor immunoglobulin light chain; and (b) a heavy chain comprising a variable heavy chain region having the sequence as set forth in residues 1–119 of SEQ ID NO:8 or SEQ ID NO:12.