Patent ID: 8193389

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein R 1 is C 1 -C 8 alkyl which is substituted with OH; R 2 is C 3 -C 6 alkenyl, substituted with 1 or 2 groups that are independently phenyl, halogen, 2H-chromenyl, 1,2,3,4-tetrahydronaphthalenyl, indolyl, 3,4-dihydronaphthalenyl, naphthyl, C 3 -C 8 cycloalkyl, benzofuranyl, indolyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, pyridyl, halogen, —CO 2 —(C 1 -C 4 alkyl), pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, triazolyl, or pyrimidyl; wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 4 alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 ) alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 ) alkyl, C 1 -C 4 alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4 alkyl, —S(O) x R 25 , —(C 1 -C 4 alkyl)S(O) x —R 25 , or OH; wherein x is 0, 1, or 2; R 25 is C 1 -C 6 alkyl, OH, NR 26 R 27 ; R 26 and R 27 are independently H, C 1 -C 6 alkyl, phenyl(C 1 -C 4 alkyl), phenyl, or pyridyl; or R 26 , R 27 and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl; R 3 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, CF 3 , CN; R 4 is halogen; and R 3′ is H, or halogen.