Patent ID: 8236352

Claim:
A composition comprising: (a) nanoparticles of spray-dried glipizide or a salt thereof, wherein the glipizide nanoparticles have an effective average particle size of less than 2000 nm; and (b) at least one surface stabilizer adsorbed on the surface of the glipizide nanoparticles; wherein: (i) the surface stabilizer is free of intermolecular cross-linkages; (ii) the glipizide nanoparticles or a salt thereof is present in an amount of from about 99.5% to about 0.001%, by weight, based on the total combined weight of the glipizide nanoparticles or a salt thereof and at least one surface stabilizer, not including other excipients; (iii) the at least one surface stabilizer is present in an amount of from about 0.5% to about 99.999% by weight, based on the total combined dry weight of the glipizide nanoparticles or a salt thereof and at least one surface stabilizer, not including other excipients; (iv) upon administration to a mammal, the glipizide nanoparticles redisperse such that the nanoparticles have an effective average particle size of less than 2 microns; and (v) the composition exhibits a C max which is at least 50% greater than the C max exhibited by a non-nanoparticulate glipizide composition when administered at the same dosage.