Patent ID: 7576112

Claim:
A compound which is a carboxylic acid or a bioisostere thereof, said carboxylic acid having a structure or a pharmaceutically acceptable salt thereof; wherein a dashed line represents the presence or absence of a bond; A is —(CH 2 ) 6 —, cis —CH 2 CH═CH—(CH 2 ) 3 —, or —CH 2 C≡C—(CH 2 ) 3 —, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is —(CH 2 ) m —Ar—(CH 2 ) o — wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH 2 — may be replaced by S or O, and 1 —CH 2 —CH 2 — may be replaced by —CH═CH— or —C≡C—; U 1 and U 2 are independently O, or S; J 1 is H; O; OH; O-alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms; alkyl having 1, 2, 3, 4, 5, or 6 carbon atoms; F; Cl; Br; I; CN; or CF 3 ; B is substituted aryl or substituted heteroaryl; and R is C 1 -C 6 alkyl or —CH 2 CH 2 OH.