Patent ID: 8034957

Claim:
A compound represented by the following general formula: wherein X is selected from the group consisting of C═O, C═S, CR 4 R 5 , O, S, NH, and NR 4 ; Z is selected from the group consisting of hydrogen, C 1 to C 8 alkyl, phenyl, hydroxymethyl, —CH 2 —N(—CH 2 CH 2 W CH 2 CH 2 —), COCH 3 , CH 2 CH 2 OH, and CH 2 CH 2 CH 2 OH; W is selected from the group consisting of O, S, CH 2 and NCH 3 ; R 1 is selected from the group consisting of hydrogen and CH 3 ; R 3 is selected from the group consisting of hydrogen, halogen, C 1 to C 8 alkyl, phenyl, hydroxymethyl, COCH 3 , CH 2 CH 2 OH, CH 2 CH 2 CH 2 OH and [C(R 2 ) 2 ] c N(R 2 ) 2 , wherein R 2 is selected from the group consisting of hydrogen, halogen, NO 2 , CN, C 1 to C 4 alkyl or aryl, and N(R 2 ) 2 may form a 3 to 7 membered heterocyclic ring, and said heterocyclic ring may be substituted with one or more of R 2 ; and [C(R 2 ) 2 ] c may form a 3 to 7 membered carbocyclic or heterocyclic ring; R 4 and R 5 may be selected from the group consisting of hydrogen, halogen, NO 2 , CN, C 1 to C 8 alkyl and aryl; or CR 4 R 5 may form a 3 to 7 membered carbocyclic or heterocyclic ring; A is 3 to 7 membered heterocyclic ring; X′ is selected from the group consisting of and B may be selected from the group consisting of hydrogen, hydroxy, C 1 to C 8 alkyl, aryl and CR 4 R 5 wherein CR 4 R 5 may form a 3 to 7 membered carbocyclic or heterocyclic ring; c is 0 or an integer of from 1 to 4, the wavy line represents a E or Z bond and pharmaceutically acceptable salts thereof.