Patent ID: 6887895

Claim:
Pseudolaric acid-B derivatives having general formula (I): wherein (a) R 1 is cyano, heterocyclyl, COXRâ€² or CON(Râ€³) 2 , wherein X is O or NH, Râ€² is H, cycloalkyl, alkyl, heterocyclic alkyl or arylalkyl, each Râ€³ is independently alkyl, cycloalkyl or heterocyclicalkyl; (b) R 2 is H, alkylacyl, arylalkylacyl, arylacyl or heterocyclylacyl; and (c) R 3 is COXY, amino or halogen, wherein X is O or NH, Y is H, NH 2 , hydroxy, alkyl, cycloalkyl, heterocyclicalkyl, hetroatom-substituted alkyl, tertiary amino-substituted ammonioalkyl, aryl, arylalkyl or polyhydroxyalkyl, Provided that pseudolaric acid A, pseudolaric acid B, pseudolaric acid C, pseudolaric acid C 2 , deacetoxyl pseudolaric acid A, deacetoxyl pseudolaric acid C 2 , methyl pseudolarate A, deacetoxyl methyl pseudolarate A, p-bromine phenacyl pseudolarate A, methyl pseudolarate B, p-bromine phenacyl pseudolarate B, methyl pseudolarate C, propyl pseudolate C, iso-propyl pseudolate C, 19-demethoxyl iso-propyl pseudolarate B, 19-demethoxyl iso-propyl pseudolarate C, 19-propyoxyl pseudolarate B, 19-propoxyl pseudolaric acid C, 19-butoxyl pseudolaric acid B, and 19-butoxyl pseudolaric acid C are excluded.