Patent ID: 8853369

Claim:
An isolated antibody that binds to human Axl, wherein the antibody binds human Axl with an affinity of ≦600 pM, wherein the antibody binds mouse Axl with an affinity of ≦1 nM, and wherein the antibody comprises (a) HVR-H1 comprising GFX 1 X 2 X 3 GX 4 WIH, wherein X 1 is T or S, X 2 is F or L, X 3 is T or S, X 4 is H, S or T (SEQ ID NO:118); (b) HVR-H2 comprising GWIX 1 PYX 2 X 3 X 4 X 5 YYADSVKG, wherein X 1 is S, N or A; X 2 is G, R or S; X 3 is G or R; X 4 is S, Y or H; X 5 is T, A or P (SEQ ID NO:119); (c) HVR-H3 comprising AREYX 1 X 2 WX 3 X 4 SX 5 X 6 GYX 7 MDY, wherein X 1 is S, N or P; X 2 is G or D; X 3 is G, R, or A; X 4 is G or S; X 5 is S or Y; X 6 is V or I; X 7 is A or E (SEQ ID NO:120); (d) HVR-L1 comprising RASQDVSTAVA (SEQ ID NO:10); (e) HVR-L2 comprising SASFLYS (SEQ ID NO:11); and (f) HVR-L3 comprising QQSYX 1 X 2 X 3 X 4 T, wherein X 1 is T, S or Y; X 2 is T, N, S or F; X 3 is P or R; X 4 is P, Y or S (SEQ ID NO:121).