Patent ID: 6890939

Claim:
A compound of Formula (II): R 1 is selected from the group consisting of hydrogen, C 1-8 alkyl, C 3-7 cycloalkyl, aryl, aryl(C 1-8 )alkyl, aryl(C 2-8 )alkenyl, heteroaryl(C 1-8 )alkyl, heteroaryl(C 2-8 )alkenyl and R 4 C(O)CH 2 —; wherein aryl and heteroaryl are optionally substituted with one to two substituents independently selected from R 4 ; R 2 is selected from the group consisting of hydrogen, hydroxy, C 1-8 alkoxy, aryloxy and aryl(C 1-8 )alkoxy; with the proviso that R 2 is bonded to the heterocyclyl ring by a single bond; alternatively, R 2 is oxo; with the proviso that R 2 is bonded to the heterocyclyl ring by a double bond; R 3 is selected from the group consisting of aryl, aryl(C 1-8 )alkyl, aryl(C 2-8 )alkenyl, heteroaryl(C 1-8 )alkyl, heteroaryl(C 2-8 )alkenyl; wherein aryl and heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of halogen, C 1-8 alkyl, C 1-8 alkoxy, amino, (C 1-4 alkyl)amino, di(C 1-4 alkyl)amino, trihalo(C 1-8 )alkyl and trihalo(C 1-8 )alkoxy; R 4 is selected from the group consisting of hydroxy, amino, C 1-8 alkyl, (C 1-4 alkyl)amino, di(C 1-4 alkyl)amino, C 1-8 alkoxy, carboxy, carboxy(C 1-8 )alkyl, carboxy(C 1-8 )alkoxy, (carboxy)amino, (carboxy(C 1-4 )alkyl)amino, (carboxyaryl)amino, (carboxyaryl(C 1-4 )alkyl)amino, (carboxy(C 1-4 )alkylaryl)amino, aryloxy, aryl(C 1-8 )alkoxy, (aryl)amino, (aryl(C 1-4 )alkyl)amino, (C 1-4 alkylaryl)amino, (arylcarboxy)amino, di(aryl)amino, di(aryl(C 1-4 )alkyl)amino, C 1-8 alkoxycarbonyl, C 1-8 alkoxycarbonyl(C 1-8 )alkoxy, aminocarbonyl, (C 1-8 alkyl)aminocarbonyl, (carboxy(C 1-8 )alkyl)aminocarbonyl, (C 1-8 alkoxycarbonyl(C 1-8 )alkyl)aminocarbonyl and guanidino; and, G is selected from the group consisting of hydrogen, halogen, hydroxy, C 1-4 alkyl, C 1-8 alkoxy, aryl, aryloxy, aryl(C 1-8 )alkyl, aryl(C 1-8 )alkoxy, amino, carboxy, alkylaminocarbonyl, alkylcarbonylamino, trihalo(C 1-8 )alkyl and trihalo(C 1-8 )alkoxy; n is 2; and pharmaceutically acceptable salts thereof.