Patent ID: 8178490

Claim:
A compound having the structure of formula IV: or a pharmaceutically acceptable salt thereof, wherein: D 8 is C; each E is independently CH or N; F is selected from the group consisting of: X is O; R 10 is selected from carbocyclyl, heterocyclyl, aryl, heteroaryl, —NHC(O)-aryl, and aralkyl, each optionally substituted with up to 3 substituents independently selected from the group consisting of a halide, alkyl optionally substituted with —CF 3 or —OH, alkylaminoalkoxy, —CF 3 , —OCF 3 , —NO 2 , —CN, —OH,═O, carbocyclyl optionally substituted with halide, heterocyclyl, aryl optionally substituted with halide or —OH, heteroaryl optionally substituted with alkyl, —O-aryl optionally substituted with —O—C 1 - C 6 alkyl, alkyl, or heterocyclyl, —O-heteroaryl optionally substituted with halide or —CF 3 , —O—heterocyclyl, —SO 2 NH-heteroaryl, —O—C 1 -C 6 alkyl optionally substituted with halide, —SO 2 N(alkyl) 2 , —SMe, —SO 2 CF 3 , di(C 1 -C 6 )alkylamino, —CH 2 -heterocyclyl optionally substituted with alkyl, —CH 2 -aryl, —C(O)aryl, and —CH═CH-aryl; R 14 is selected from H, —C(O)—CH(Me)(NH 2 ), —C(O)CH(NH 2 )(arylether), —C(O)CH(NH 2 )(aminoalkyl), —C(O)—CH(CH 2 OH)(NH 2 ), and —(CH 2 ) t NH; R 15 and R 16 are independently selected from —NH 2 , —NHC(═NH)NH 2 , + (CH 3 ) 3 , —NHCH 2 CH 2 NH 2 , —N(CH 2 CH 2 NH 2 ) 2 , —C(O)N(CH 2 CH 2 NH 2 ) 2 , —CH(CH 2 NH 2 ) 2 , and —CH 2 (NH 2 )(CH 2 NH 2 ), or R 15 and R 16 together with F form a heterocyclyl substituted with one or more substituents independently selected from —(CH 2 ) s NH 2 , —(CH 2 ) s NHC(═NH)NH 2 , —(CH 2 ) s N + (CH 3 ) 3 , —(CH 2 ) s NHCH 2 CH 2 NH 2 , —(CH 2 ) s N(CH 2 CH 2 NH 2 ) 2 , —(CH 2 ) s C(O)N(CH 2 CH 2 NH 2 ) 2 , and —(CH 2 ) s CH(CH 2 NH 2 ) 2 ; R 17 is selected from alkyl, aralkyl, arylthioether, arylether, heteroaralkyl, carbocyclyl-alkyl, heterocyclyl-alkyl, aryl, and carbocyclyl, each optionally substituted with up to 3 substituents independently selected from the group consisting of —CF 3 , —OH, —OCF 3 , halide, —CN, alkyl, —O-aralkyl, aryl, —S(CH 3 ) 2 , —C(O )aryl, —S-aralkyl optionally substituted with —OMe, ═O, and ═N—OH; R 18 is H, R 19 is H, —NH 2 , —CH 2 NH 2 , or —CH 2 CH 2 NH 2 ; R 20 is H or C 1 -C 4 alkyl; R 21 is —NH 2 , —OH, alkyl, t is an integer from 0 to 4; each s is independently an integer from 0 to 3; r is 1; v is 0 or 1; and n is an integer from 0 to 4.