Patent ID: 7544707

Claim:
A compound of the structural Formula II: and stereoisomers, pharmaceutically acceptable salts thereof, wherein: (a) R1 is hydrogen or C 1 -C 8 alkyl; (b) R31 is selected from the group consisting of hydrogen, hydroxy, cyano, nitro, halo, oxo, C 1 -C 6 alkyl, C 1 -C 6 alkyl-COOR12, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkyloxy, C 3 -C 7 cycloalkyl, aryloxy, aryl-C 0-4 -alkyl, heteroaryl, heterocycloalkyl, C(O)R13, COOR14, OC(O)R15, OS(O) 2 R16, N(R17) 2 , NR18C(O)R19, NR20SO 2 R21, SR22, S(O)R23, S(O) 2 R24, and S(O)2N(R25)2; R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24 and R25 are each independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl and aryl; (c) R2 is a bond; (d) X is selected from the group consisting of a single bond, O and S; (e) U is C 1 -C 3 alkyl, and wherein such alkyl is substituted with from one to four substituents each independently selected from R30; (f) Y is selected from the group consisting of C, O and S; (g) E is C(R3)(R4)A and wherein (i) A is carboxyl; (iii) R3is selected from the group consisting of hydrogen, C 1 -C 5 alkyl, and C 1 -C 5 alkoxy; and (iv) R4 is selected from the group consisting of H, C 1 -C 5 alkyl, C 1 -C 5 alkoxy, aryloxy, C 3 -C 6 cycloalkyl, and aryl C 0 -C 4 alkyl, and R3and R4 are optionally combined to form a C 3 -C 4 cycloalkyl, and wherein alkyl, alkoxy, aryloxy, cycloalkyl and aryl-alkyl are each optionally substituted with one to three substituents each independently selected from R26; (h) R8 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, and C 1 -C 4 alkylenyl; (i) R9 is selected from the group consisting of hydrogen and C 1 -C 4 alkyl; R8 and R9 optionally combine to form a five membered fused bicyclic with the phenyl to which R8 and R9 attach, provided that when R8 and R9 form a fused ring, the group E-Y— is bonded at any available position on the five membered ring of such R8 and R9 fused bicyclic; (j) R10, is CF 3 ; (k) R11 is hydrogen; (l) R30 is selected from the group consisting of C 1 -C 6 alkyl, aryl-C 0-4 -alkyl, aryl-C 1-4 -heteroalkyl, heteroaryl-C 0-4 -alkyl, and C 3 -C 6 cycloalkylaryl-C 0-2 -alkyl, and wherein C 1 -C 6 alkyl, aryl-C 0-4 -alkyl, aryl-C 1-4 -heteroakyl, heteroaryl-C 0-4 -alkyl, and C 3 -C 6 cycloalkylaryl-C 0-2 -alkyl are each optionally substituted with from one to three substituents each independently selected from R31; (m)R32 is selected from the group consisting of hydrogen, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, and C 1 -C 6 alkyloxo; (n) AL is a fused phenyl; and (o) - - - is each optionally a bond to form a double bond at the indicated position.