Patent ID: 7544207

Claim:
A prosthetic valve for selectively permitting fluid flow through a body vessel in a first direction and substantially preventing fluid flow through said body vessel in a second, opposite direction, said prosthetic valve comprising: a support frame having radially expanded and radially compressed configurations; a first bioremodellable leaflet attached to the support frame and including a first base portion attached to the support frame and a first free edge that is moveable within said body vessel; a second bioremodellable leaflet attached to the support frame and including a second base portion attached to the support frame and a second free edge that is moveable within said body vessel; and an antiproliferative agent associated with at least one of the first and second free edges; wherein the first and second free edges cooperatively define a valve orifice that opens and closes in response to movement of the first and second free edges; and wherein the first and second base portions are free of the antiproliferative agent such that remodelling of the at least one free edge with which the antiproliferative agent is associated is delayed with respect to remodelling of the first and second base portions.