Patent ID: 7094781

Claim:
A compound of general formula I or an optically pure enantiomer or diastereomer, a mixture of enantiomers or diastereomers, a diastereomeric racemate, a mixture of diastereomeric racemates or a meso-form or a pharmaceutically acceptable salt thereof; wherein R 1 represents aryl; aryl-lower alkyl; heteroaryl; heteroaryl-lower alkyl; cycloalkyl; cycloalkyl-lower alkyl; heterocyclyl; heterocyclyl-lower alkyl; lower alkyl; or hydrogen; R 2 represents —CH 3 ; —(CH 2 ) n —Y—R a ; —(CH 2 ) m —C≡C—(CH 2 ) p -Z-R a ; —(CH 2 ) k —C(R b )═CR c R d ; or —CH 2 -tetrahydrofuran-2-yl; R 3 represents aryl; or heteroaryl; R 4 represents hydrogen; trifluoromethyl; lower alkyl; lower alkyl-amino; lower alkyloxy; lower alkyloxy-lower alkyloxy; hydroxy-lower alkoxy; lower alkyl-sulfinyl; lower alkylthio; lower alkylthio-lower alkyl; hydroxy-lower alkyl; lower alkyl-oxylower alkyl; hydroxy-lower alkyl-oxy-lower alkyl; hydroxy-lower alkyl-amino; lower alkyl-amino-lower alkyl; amino; di-lower alkyl-amino; [N-(hydroxy-lower alkyl)-N(lower alkyl)]-amino; aryl; aryl-amino; aryl-lower alkyl-amino; aryl-thio; aryl-lower alkyl-thio; aryloxy; aryl-lower alkyl-oxy; aryl-lower alkyl; aryl-sulfinyl; heteroaryl; heteroaryl-oxy; heteroaryl-lower alkyl-oxy; heteroaryl-amino; heteroaryl-lower alkyl-amino; heteroaryl-thio; heteroaryl-lower alkyl-thio; heteroaryl-lower alkyl; heteroaryl-sulfinyl; heterocyclyl; heterocyclyl-lower alkyl-oxy; heterocyclyl-oxy; heterocyclyl-amino; heterocyclyl-lower alkyl-amino; heterocyclyl-thio; heterocyclyl-lower alkyl-thio; heterocyclyl-lower alkyl; heterocyclyl-sulfinyl; cycloalkyl; cycloalkyl-oxy; cycloalkyl-lower alkyl-oxy; cycloalkyl-amino; cycloalkyl-lower alkyl-amino; cycloalkyl-thio; cycloalkyl-lower alkyl-thio; cycloalkyl-lower alkyl; or cycloalkylsulfinyl; R 6 represents hydrogen; or lower alkyl; X represents oxygen; sulfur; —CH 2 — or a bond; Y represents a bond, —O—; —NH—; —NH—SO 2 —; —NH—SO 2 —NH—; O—CO—; —CO—O—; —O—CO—NH—; —NH—CO—O—; or —NH—CO—NH—; Z represents oxygen or a bond; k represents 1, 2, 3, 4, 5 or 6; n represents 2, 3, 4, 5 or 6; m represents 1, 2, 3, 4 or 5; p represents 0 (zero), 1, 2 or 3 and if p represents 0 (zero), Z cannot represent oxygen; R a represents aryl; heteroaryl; lower alkyl; cycloalkyl; or hydrogen; R b and R c independently represent hydrogen or lower alkyl; and R d represents hydrogen; lower alkyl; aryl; or heteroaryl.