Patent ID: 7812013

Claim:
A compound having the structural formula or a pharmaceutically acceptable salt or ester thereof, wherein R 1 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylcycloalkyl, —OR 19 , —CN, —C(O)R 20 , —C(O)OR 19 , —S(O) 1-2 R 21 , —C(O)N(R 22 )(R 23 ), —S(O) 1-2 N(R 22 )(R 23 ), —NO 2 , —N═C(R 22 )(R 23 ) and —N(R 22 )(R 23 ); R 2 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylal kyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylcycloalkyl, —CF 3 , —CN, —C(O)R 20 , —C(O)OR 19 , and —C(O)N(R 22 )(R 23 ); e is 3; R 11 and R 12 are each independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylcycloalkyl, halo, —CF 3 —SH, —OR 19 , —CN, —C(O)R 20 , —C(O)OR 19 , —S(O) 0-2 R 21 , —S(O) 1-2 N(R 22 )(R 23 ), —C(O)N(R 22 )(R 23 ), —N(R 22 )C(O)R 20 , —N(R 22 )C(O)N(R 22 )(R 23 ), —N(R 22 )C(O)OR 19 , —N(R 22 )S(O) 1-2 R 21 , —NO 2 , —N═C(R 22 )(R 23 ) and —N(R 22 )(R 23 ), Y is selected from the group consisting of —O—, —N(R 5 )—. —C(O)—. —S(O) 0-2 —, —C(O)N(R 22 )—. —N(R 22 )C(O)—. —S(O) 1-2 N(R 22 )—, —N(R 22 )S(O) 1-2 — or a bond; R 19 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, arylalkyl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R 20 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, arylalkyl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, —NH 2 , —NH(alkyl), or —N(alkyl) 2; R 21 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, arylalkyl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R 22 and R 23 are H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, arylalkyl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; and each R 24 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylcycloalkyl, halo, —CF 3 , —SH, —OR 19 , —CN, —C(O)R 20 , —C(O)OR 19 , —S(O) 0-2 R 21 , —S(O) 1-2 N(R 22 )(R 23 ), —C(O)N(R 22 )(R 23 ), —N(R 22 )C(O)R 20 , —N(R 22 )C(O)N(R 22 )(R 23 ), —N(R 22 )C(O)OR 19 , —N(R 22 )S(O) 1-2 R 21 , —NO 2 , —N═C(R 22 )(R 23 ) and —N(R 22 )(R 23 ); wherein s is 1 or 2 and t is 1 or 2.