Patent ID: 8846712

Claim:
A compound of formula I wherein R 1 is a) a residue of formula Ia wherein R 6 is H, F, Cl, (C 1 -C 3 )-alkyl or O—(C 1 -C 3 )-alkyl, wherein (C 1 -C 3 )-alkyl is unsubstituted or substituted by one to five F; R 7 is H, F, Cl, (C 1 -C 3 )-alkyl or O—(C 1 -C 3 )-alkyl, wherein (C 1 -C 3 )-alkyl is unsubstituted or substituted by one to five F, or is CN, SO 2 (C 1 -C 3 )-alkyl, N((C 1 -C 4 )-alkyl) 2 1-piperidinyl, or 4-morpholinyl; R 8 is H, F, Cl, (C 1 -C 5 )-alkyl or O—(C 1 -C 5 )-alkyl, wherein (C 1 -C 3 )-alkyl is unsubstituted or substituted by one to five F, or is OH, O-phenyl, SO 2 (C 1 -C 3 )-alkyl, CO—(C 1 -C 4 )-alkyl, or CO—N((C 1 -C 4 )-alkyl) 2 ; or R 7 and R 8 form, together are R 9 is H, F, CH 3 , or O—CH 3 ;and R 10 is H; or b) ethylene-phenyl, wherein phenyl is unsubstituted or substituted by one or two identical or different substituents selected from F, Cl, CH 3 , O—CH 3 , CF 3 , O—CF 3 , CN, SO 2 CH 3 , CO—CH 3 , and CO—N((CH 3 ) 2 ; and R 2 is H, or CH 3 ; R 3 is H, or O—CH 3 ; and R 4 is piperidin-4-yl, piperidin-3-yl or pyrrolidin-3-yl, which are unsubstituted or monosubstituted by (C 1 -C 3 )-alkyl, which is unsubstituted or substituted by one to five F, and R 5 is H, or R 4 and R 5 together with the nitrogen carrying them form a) a residue of formula Ib wherein R 11 is H, CH 3 ,(C 3 -C 5 )-cycloalkyl, or (C 3 -C 4 )-alkyl, and R 12 is H, or R 11 and R 12 together with the C-atoms form 1′-spiro-cyclopentyl; R 13 is H, (C 1 -C 4 )-alkyl, or (C 3 -C 5 )-cycloalkyl, and R 14 is H, or CH 3 or R 13 and R 14 together with the C-atom carrying them is 1′-spiro-cyclo-(C 3 -C 6 )-alkyl; R 15 is H, CH 2 —CO—N((C 1 -C 4 )-alkyl) 2 , CO—(C 1 -C 6 )-alkyl, CO—(C 1 -C 4 )-alkylene-OH, CO—(C 1 -C 4 )-alkylene-O—CH 3 , CO—CH 2 -4-morpholinyl, CO—O—(C 1 -C 4 )-alkyl, CO—N((C 1 -C 4 )-alkyl) 2 , (C 3 -C 6 )-cycloalkyl, or pyridyl; R 16 is H, or (C 1 -C 4 )-alkyl; R 17 is H; R 18 is H; and R 19 is H; or b) a 9 to 11 membered spiro-heterocycloalkyl containing 2 nitrogen atoms, which is attached via a nitrogen atom; or a pharmaceutically acceptable salt thereof.