Patent ID: 7456158

Claim:
A method for treating a mammal suffering from a condition that benefits from a non-antimicrobial dose of a tetracycline compound, said condition being characterized by excessive collagen destruction, excessive MMP enzyme activity, excessive TNF activity, excessive nitric oxide activity, excessive IL-1 activity, excessive elastase activity, excessive loss of bone density, excessive protein degradation, excessive muscle wasting, excessive glycosylation of collagen, excessive COX-2 activity, insufficient bone protein synthesis, insufficient interleukin-10 production or excessive phospholipase A 2 activity, the method comprising administering to the mammal an effective amount of a 4-de(dimethylamino) doxycycline compound having structure L, M, N, or O wherein: R7, R8, and R9 taken together in each case, have the following meanings: R7 R8 R9 hydrogen hydrogen palmitamide (COL-803) hydrogen hydrogen nitro (COL-804) hydrogen hydrogen amino (COL-805) wherein said condition is abdominal aortic aneurysm, ulceration of the cornea, periodontal disease, diabetes, diabetes mellitus, scleroderma, progeria, graft versus host disease, disease of depressed bone marrow function, thrombocytopenia, prosthetic joint loosening, spondyloarthropathies, osteoporosis, Paget's disease, systemic lupus erythematosis, inflammatory bowel disease, arthritis, osteoarthritis, rheumatoid arthritis, pancreatitis, nephritis, glomerulonephritis, sepsis, septic shock, lipopolysaccharide endotoxin shock, multisystem organ failure, psoriasis, ARDS, cystic fibrosis, emphysema, acute lung injury resulting from inhalation of toxicants, chronic renal failure, acute renal failure, nephritis or glomerulonephritis.