Patent ID: 8063068

Claim:
A vinylazacycloalkane compound of Formula (I): wherein: the wavy line represents E geometry about the double bond; X is CR 2 ; R 1 is hydrogen, C 1-6 -alkyl, halogen, —OR 4 , —NR 4 R 5 , or —SR 4 ; R 2 is hydrogen, C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, heteroaryl, heteroaryl-C 1-6 -alkyl, heterocyclyl, heterocyclyl-C 1-6 -alkyl, cycloalkyl, polycycloalkyl, —OR 6 , —NR 6 R 7 , —SR 6 , —SOR 6 , or —SO 2 R 6 , wherein the C 1-6 -alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl groups may be substituted with one or more substituents selected from the group consisting of F, CI, Br, I, —R 8 , —OR 8 , —NR 8 R 9 , —CF 3 , —OCF 3 , —CN, —NO 2 , —SR 8 , —S(O)R 8 , —SO 2 R 8 , —O—SO 2 R 8 , —C(═O)NR 8 R 9 , —NR 8 C(═O)R 9 , —C(═O)OR 8 , —OC(═O)R 8 , —NHSO 2 R 8 , —SO 2 NR 8 R 9 , —C(S)NR 8 R 9 , and —NHC(S)R 8 ; R 3 is hydrogen or methyl; R 4 and R 5 are, independently, hydrogen or C 1-6 -alkyl; R 6 and R 7 are, independently, hydrogen, C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, heteroaryl, heteroaryl-C 1-6 -alkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, or polycycloalkyl, wherein the C 1-6 -alkyl, cycloalkyl, heterocyclyl, heteroaryl and aryl groups can be substituted with one or more substituents selected from the group consisting of F, CI, Br, I, —R 8 , —NR 8 R 9 , —CF 3 , —CN, —NO 2 , —C 2 R 8 , —N 3 , —SO 2 CH 3 , —OR 8 , —SR 8 , —C(═O)NR 8 R 9 , —NR 8 C(═O)R 8 , —C(═O)R 8 , —C(═O)OR 8 , —(CH 2 ) q OR 8 , —OC(═O)R 8 , —OC(═O)NR 8 R 9 , and —NR 8 C(═O)OR 8 ; R 8 and R 9 are, independently, hydrogen, C 1-6 -alkyl, or an aromatic group-containing species, wherein the aromatic group-containing species can be substituted with one or more of C 1-6 -alkyl, halogen, or amino; or either R 6 and R 7 together or R 8 and R 9 together with the atoms to which they are attached form a 3- to 10-membered ring; m is 1, 2, 3, or 4; and n is 1, 2, or 3; or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt thereof.