Patent ID: 7078191

Claim:
A composition comprising (a) a nucleic acid molecule encoding a fusion protein comprising (aa) a glutathione S-transferase (GST) (poly)peptide that enhances solubility and/or prevents aggregation of said fusion protein; and (ab) a huntingtin (poly)peptide that has the ability to self-assemble into fibrils or protein aggregates, wherein connection of polypeptides (aa) and (ab) is via a linker or by a direct attachment, and wherein at least one of the linker, (poly)peptide (aa) and (poly)peptide (ab) includes a cleavable site, and wherein said huntingtin (poly)peptide self-assembles subsequent to release from said fusion protein, (b) a vector containing the nucleic acid molecule of (a); (c) a host transformed with the vector of (b); and/or (d) a fusion protein encoded by the nucleic acid of (a).