Patent ID: 8278313

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: G 1 is CH 2 CH 2 ; G 2 is CH 2 ; wherein each carbon of G 1 and G 2 may be optionally substituted with one or more groups selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkyl, alkoxyalkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcycloalkyl, alkylsulfonyl, alkylthio, alkynyl, amido, carboxy, cyano, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, fluoroalkoxy, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, and oxo; G 4 is a bond; R 1 is selected from hydrogen, NH 2 , —NH(acyl), —NH(alkyl), —N(alkyl) 2 , —NH(C═O)aryl, —NH-alkylene(NR 8 R 9 ), —NH(C═O)-alkylene(NR 8 R 9 ), —NR 8 (C═O)NR 8 R 9 , —NH-alkylene-heteroaryl, —NHOH, —NHOCH 3 , —O-alkylene(NR 8 R 9 ), alkoxy, alkoxycarbonyl, alkyl, carboxy, —(C═O)—(NR 8 R 9 ), —(C═O)—NH-alkylene(NR 8 R 9 ), cyano, cyanoalkyl, cycloalkyl, fluoroalkyl, fluorocycloalkyl, hydroxyalkyl, and piperazinyl; R 8 and R 9 each are each independently selected from acyl, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcycloalkyl, alkylsulfonyl, amido, aryl, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, heteroaryl, heterocyclyl, hydrogen, formyl, hydroxy, and hydroxyalkyl; R 10 and R 11 taken together are alkylene, —OCH 2 CH 2 O—, —OCH 2 CH 2 CH 2 O—, or —CH 2 CH 2 OCH 2 CH 2 —, A 1 is and wherein each carbon atom of groups A 1 may be optionally substituted with one or more groups selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcycloalkyl, alkylsulfonyl, alkylthio, alkynyl, amido, carboxy, cyano, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, fluoroalkoxy, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, formyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, and nitro.