Patent ID: 6849634

Claim:
A compound having potassium channel inhibitory activity of formula (I), or a pharmaceutically acceptable salt thereof: wherein, A, B, and D are substituted carbon atoms; E is hydrogen, or alkyl; G is hydrogen, or alkyl; or E and G taken together form a bond (site of unsaturation); R 1 is selected from hydrogen, alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, and (heteroaryl)alkyl; R 2 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (hetercyclo)alkyl, heteroaryl, and (heteroaryl)alkyl, each of which may be optionally substituted; R 3 is selected from hydrogen (H), alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, (heteroaryl)alkyl, aminoalkyl; substituted aminoalkyl, carboxyalkyl, alkoxyalkanoyl, aminoalkanoyl, substituted aminoalkanoyl, alkanoylamidoalkyl, alkanoyl(substituted amido)alkyl, aroylamidoalkyl, aroyl(substituted amido)alkyl, heterocyclocarbonylamidoalkyl, heterocyclocarbonyl(substituted amido)alkyl, heteroaroylamidoalkyl, and heteroaroyl(substituted amido)alkyl; R 4 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heteroaryl and heterocyclo; R 5 and R 6 are each independently selected from hydrogen, fluoro and alkyl; R 7 is independently selected from hydrogen, alkyl, hydroxy, alkoxy, amino, substituted amino, nitro, cyano, halo, carboxy, alkoxycarbonyl, aminocarbonyl, substituted aminocarbonyl and n is 1, 2 or 3; and Z is selected from hydrogen, alkyl, hydroxy, SH, alkoxy, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted) amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido, and heterocyclocarbonyl(alkyl substituted)amido.