Patent ID: 8513199

Claim:
A method for treating cancer in a cancer patient comprising administering an effective amount of an antibody or antibody fragment to the patient, wherein (a) the antibody or antibody fragment binds human c-fms and comprises: (i) a heavy chain variable domain comprising a CDRH1, a CDRH2 and a CDRH3, wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:147, the CDRH2 comprises the amino acid sequence of SEQ ID NO:163, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:186; and (ii) a light chain variable domain comprising a CDRL1, a CDRL2 and a CDRL3, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:193; the CDRL2 comprises the amino acid sequence of SEQ ID NO:214 and the CDRL3 comprises the amino acid sequence of SEQ ID NO:228; and (b) the cancer is selected from the group consisting of breast cancer, prostate cancer, endometrial cancer, bladder cancer, kidney cancer, esophageal cancer, squamous cell cancer, uveal melanoma, follicular lymphoma, renal cancer, cervical cancer, gastric cancer, astrocytic cancer, lung cancer, ovarian cancer, and colorectal cancer.