Patent ID: 8080421

Claim:
A method of predicting a solution condition that yield beneficial solubility or stability conditions for a polypeptide of interest, the method comprising the steps of: a. conducting an initial screen, the initial screen comprising a plurality of conditions, each condition having one or more condition variables; b. obtaining at least one dilute solution thermodynamic virial coefficient (B) parameter for one or more of the conditions in the initial screen; c. inputting a data set into a predictive function, the data set comprising the B parameter for one or more of the conditions and optionally information regarding the condition variables for one or more of the conditions comprising the initial screen; d. training the predictive function using the data set; and e. generating the solution condition that yield beneficial solubility or stability conditions for a polypeptide of interest using the trained predictive function, the predicted solution condition not being contained in the initial screen.