Patent ID: 8217017

Claim:
A composition comprising an antisense compound consisting of a modified oligonucleotide consisting of 20 linked nucleosides and consisting of a nucleobase sequence recited in SEQ ID NO: 125, wherein said compound inhibits the expression of IGF-IR, and wherein said modified oligonucleotide consists of a ten deoxynucleotide region flanked on both the 5′ and 3′ end of said ten deoxynucleotide region with five 2′-O-(2-methoxyethoxy)nucleotides, wherein each internucleoside linkage in said modified oligonucleotide is a phosphorothioate linkage and each cytosine in said modified oligonucleotide is a 5-methylcytosine, said composition further comprising one or more pharmaceutically acceptable carriers and/or diluents.