Patent ID: 8252792

Claim:
A compound which is a thienopyrimidine of formula (Ia) or (Ib): wherein R 1 is a group of formula: R 2 is H, halo or C 1 -C 6 alkyl; R 3 is an indole group which is unsubstituted or substituted; R 4 and R 5 form, together with the N atom to which they are attached, a group selected from piperazine, piperidine and pyrrolidine, which group is unsubstituted or substituted by one or more groups selected from C 1 -C 6 alkyl, —S(O) 2 R 10 , —S(O) 2 -(alk) q -NR 11 R 12 , oxo (═O), -alk-OR 10 , -(alk) q -Het, a heterocyclyl group and —NR 13 R 14 ; or one of R 4 and R 5 is C 1 -C 6 alkyl and the other is a piperazine, piperidine or pyrrolidine group, which group is unsubstituted or substituted; R 10 is H or C 1 -C 6 alkyl which is unsubstituted; R 11 and R 12 are each independently selected from H and C 1 -C 6 alkyl which is unsubstituted, or R 11 and R 12 together form, with the N atom to which they are attached, a 5- or 6-membered saturated heterocyclic group; R 13 and R 14 are each independently selected from C 1 -C 6 alkyl, —S(O) 2 R 10 , alk-OR 10 , -(alk) q -Ph and -(alk) q -Het; Ph is phenyl; q is 0 or 1; Het is a thiazole, imidazole, pyrrole, pyridine or pyrimidine group, which group is unsubstituted or substituted; and alk is C 1 -C 6 alkylene; or a pharmaceutically acceptable salt thereof; with the proviso that, in formula (Ia) only, when R 2 is H and R 3 is unsubstituted indole, then —NR 4 R 5 is other than (i) piperazine which is unsubstituted or substituted by one substituent selected from methyl, —S(O) 2 Me and —CH 2 CH 2 OH; and (ii) piperidine which is substituted by one substituent selected from —NMe 2 , —N(Me)(CH 2 CH 2 OMe) and morpholino.