Patent ID: 6949552

Claim:
The therapeutic preparation for anxiety neurosis or depression which contains a piperazine derivative having MC 4 receptor antagonist action as an effective ingredient, wherein the piperazine derivative is represented by Formula 1: wherein Ar 1 is a phenyl group, a substituted phenyl group, a naphthyl group or a substituted naphthyl group; Ar 2 is a naphthyl group, a substituted naphthyl group, a quinolyl group, a group represented by the formula: (wherein R 4 is a hydrogen atom or a halogen atom; and X—Y is CH—NH, CH—O, CH—S or N—O) or a group represented by the formula: (wherein R 5 is a hydrogen atom, a hydroxyl group or a C 1-10 alkoxy group); R 1 is a hydrogen atom, a C 1-10 alkyl group, a C 3-8 cycloalkyl group, a C 3-10 alkenyl group, a phenyl group, a 1-cyanoethyl group, or a pyrimidin-2-yl group; R 2 and R 3 are the same or different, and are each a hydrogen atom or a C 1-10 alkyl group; A-B is N—CH 2 , CH—CH 2 , C(OH)—CH 2 or C═CH; T 1 is a single bond, —N(R 60 )— (wherein R 6 is a hydrogen atom or a C 1-10 alkyl group), —O—, —CH═CH— or —C(═O)—; n is an integer of from 1 to 10 when T 1 is single bond, —CH═CH— or —C(═O)—, and n is an integer of from 2 to 10 when T 1 is —N(R 8 )— or —O— , or a pharmaceutically acceptable salt thereof.