Patent ID: 7511013

Claim:
A compound of Formula Ia: wherein: X is OH or OAc; R 0 is H or CH 2 OR 3 ; R 1 is H or D; R 2 is selected from the group consisting of: halogen, C 3 -C 6 unsubstituted cycloalkyl, â€”CHâ•Nâ€”OR 4 , and â€”CHâ•Nâ€”NR 4 R 5 ; R 3 is selected from the group consisting of: hydrogen, alkanoyl, alkenoyl, alkynoyl, aryloyl, arylalkanoyl, alkylaminocarbonyl, arylaminocarbonyl, arylalkylaminocarbonyl, alkyloxycarbonyl, aryloxycarbonyl, and arylalkyloxycarbonyl; R 4 and R 5 are the same or different and independently selected from the group consisting of: hydrogen, C 1 -C 6 saturated straight or branched carbon chain, C 3 -C 6 unsaturated straight or branched carbon chain, C 3 -C 6 -substituted and unsubstituted cycloalkyl, C 1 -C 4 carbon chain containing an aryl or heteroaryl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, alkanoyl, alkenoyl, alkynoyl, aryloyl, arylalkanoyl, alkylaminocarbonyl, arylaminocarbonyl, arylalkylaminocarbonyl, alkyloxycarbonyl, aryloxycarbonyl, arylalkyloxycarbonyl, alkylsulfonyl, and arylsulfonyl; and R 4 together with R 5 results in the formation of a cyclic moiety of C 2 -C 6 optionally containing heteroatom or heteroatoms, wherein the compound is a cis geometric isomer, a trans geometric isomer, or a mixture of the cis and the trans geometric isomers or a pharmaceutically acceptable salt thereof.