Patent ID: 8614321

Claim:
A compound of structural formula (I): or a pharmaceutically acceptable salt thereof, wherein: X 1 , X 2 , and X 3 are, independently, CH, CR 1 , or N; L is a linker selected from the group consisting of —NRC(R) 2 —, —C(R) 2 NR—, —C(O)—, —NR—C(O)—, —C(O)—NR—, —C(S)—, —C(NR 8 )—, —NR—C(S)—, —C(S)—NR—, —NR—C(NR 8 )—, —C(NR 8 )—NR—, —NRC(O)NR—, —NRC(S)NR—, —NRC(NR 8 )NR—, —S(O) 2 NR—, —NRS(O) 2 —, —NRS(O) 2 NR—, —NRC(R) 2 NR—, —O—, —S—, —NR—, —CR═CR—, —C≡C—, —N═CR—, —CR═N—, —NR—N═CR—, and —CR═N—NR—; Y is an alkyl, a cycloalkyl, a heterocyclyl, an aryl, or a heteroaryl; wherein each of Y is independently optionally substituted with one or two substituents selected from the group consisting of a halo, nitro, cyano, a haloalkyl, a haloalkoxy, an alkyl, an alkoxy, an alkylsulfanyl, an alkylamino, a dialkylamino, a cycloalkyl, and a heterocyclyl; each Z is independently selected from the group consisting of a lower alkyl, a lower haloalkyl, a halo, a lower alkoxy, a lower alkyl sulfanyl, cyano, nitro, —N(R) 2 , —NRC(O)R, —C(O)N(R) 2 , or lower haloalkoxy; R, for each occurrence, is independently, H or a lower alkyl; R 1 , for each occurrence, is independently a substituent selected from the group consisting of a halo, nitro, cyano, a haloalkyl, a haloalkoxy, —OR 5 , —SR 5 , —NR 6 R 7 , an alkyl, a cycloalkyl, a heterocyclyl, an aryl, a heteroaryl, an aralkyl, a heteraralkyl, —C(O)NR 6 R 7 , —C(O)R 5 , —S(O) p R 5 , —S(O) p NR 6 R 7 , —OC(O)R, —NRC(O)R, and —C(O)OR 5 ; R 4 is a substituent selected from the group consisting of H, a halo, nitro, cyano, a haloalkyl, a haloalkoxy, —OR 5 , —SR 5 , —NR 6 R 7 , an alkyl, a cycloalkyl, a heterocyclyl, an aryl, a heteroaryl, an aralkyl, a heteraralkyl, —C(O)NR 6 R 7 , —C(O)R 5 , —S(O) p R 5 , —S(O) p NR 6 R 7 , and —C(O)OR 5 ; R 5 , for each occurrence, is independently, H, an alkyl, a cycloalkyl, a heterocyclyl, an aryl, a heteroaryl, an aralkyl, or a heteraralkyl; R 6 and R 7 , for each occurrence are, independently, H, an alkyl, a cycloalkyl, a heterocyclyl, an aryl, a heteroaryl, an aralkyl, or a heteraralkyl; or R 6 and R 7 taken together with the nitrogen to which they are attached are a heterocyclyl or heteroaryl; R 8 , for each occurrence, is independently —H, a halo, an alkyl, —OR 5 , —NR 6 R 7 , —C(O)R 5 —, C(O)OR 5 , or —C(O)NR 6 R 7 ; p is 1 or 2; m is 0, 1, or 2; and n is 0, 1 or 2.