Patent ID: 8921306

Claim:
A peptide of formula (I): R 1 -Xaa 1 Xaa 2 Xaa 3 Xaa 4 Xaa 5 Xaa 6 Lys 1 Xaa 7 Xaa 8 Xaa 9 Asp 1 Arg 1 Lys 2 Lys 3 Xaa 10 Xaa 11 Xaa 12 Asp 2 -R 2 (I) wherein Xaa 1 is Phe or N-BzlGly; Xaa 2 is Gly; Xaa 3 is Gly or Ala; Xaa 4 is Phe or 4-R 3 -Phe; Xaa 5 is Thr or Ser; Xaa 6 is selected from Gly, L-Ala, L-Ser, L-Lys, L-Arg, L-Pro, L-Glu, L-Ile, L-Met and L-Val; Xaa 7 is selected from L-Arg, L-Lys, L-Orn, L-Ala, L-Leu, L-Met, L-Glu, L-Gln, L-Cys, L-Val, L-Ile, L-Phe, L-Tyr, L-Trp, L-Thr, L-Ser and L-Asp; Xaa 8 is selected from L-Lys, L-Orn, L-Arg, L-His, L-2,3-diaminopropionic acid and L-2,4-diaminobutanoic acid; Xaa 9 is selected from L-Ser, L-Thr, L-Cys, L-Asn, L-Gln, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Met, L-Phe, L-Trp and L-Arg; Xaa 10 is selected from L-Ala, L-Lys, L-Arg, L-Orn, L-Leu, L-Ile, L-Val, L-Met, L-Phe, L-Trp, L-Ser, L-Thr, L-Cys, L-Gln, L-Asn, L-Tyr and L-His; Xaa 11 is selected from L-Asn, L-Ser, L-Thr, L-Cys, L-Gln, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Met, L-Phe and L-Trp; Xaa 12 is selected from L-Gln, L-Asn, L-Arg, L-Lys, L-Ser, L-Thr, L-Cys, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Met, L-Phe and L-Trp; R 1 is hydrogen or an N-terminal capping group, with the proviso that when Xaa 1 is N-BzlGly, R 1 is absent; R 2 is —OH or a C-terminal capping group; and R 3 is an electron withdrawing substituent; wherein the side chains of Lys 1 and Asp 1 are linked to form a lactam bridge and the side chains of Lys 3 and Asp 2 are linked to form a lactam bridge; or a pharmaceutically acceptable salt thereof.