Patent ID: 7208497

Claim:
A compound of formula (I): wherein designates a single bond or a double bond, R 1 is C 3-8 -cycloalkyl, C 5-8 -cycloalkenyl, di(C 3-8 -cycloalkyl)-C 1-6 -alkyl, C 3-8 -cycloalkyl-C 2-6 -alkenyl, C 3-8 -cycloalkyl-C 2-6 -alkynyl, C 5-8 -cycloalkenyl-C 1-6 -alkyl, C 5-8 -cycloalkenyl-C 2-6 -alkenyl, or C 5-8 -cycloalkenyl-C 2-6 alkynyl, wherein the cyclic moieties may optionally be substituted with one or more substituents selected from the group consisting of C 1-6 -alkyl, halogen, trifluoromethyl, 2,2,2-trifluoroethyl and C 3-8 -cycloalkyl, X is —(CH 2 )—(Z) n —(CR 2 R 3 ) o —(CH 2 ) p —(V) q —, p is 0, 1, 2, 3 or 4, n, o and q independently are 0 or 1, Z and V independently are —O—, —C(═O)—, —S—, —S(═O)—, —S(═O) 2 —, or —C≡C—, R 2 and R 3 independently are hydrogen, C 1-6 -alkyl or hydroxy, Y is aryl which may optionally be substituted with one or more substituents selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1-7 -alkanoyl, C 1-6 -alkylthio, C 1-6 -alkylsulfonyl, C 1-6 -alkyl, C(═O)O—C 1-6 -alkyl, C 3-8 -cycloalkyl, trifluoromethyl, trifluoromethoxy, —NR 4 R 5 and —O(C═O)NR 4 R 5 , or wherein two substituents in adjacent positions together form a radical —O—(CH 2 ) 1-3 —O—, wherein R 4 and R 5 independently are hydrogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, C 1-7 -alkanoyl or aryl, or —R 4 and R 5 together with the nitrogen atom to which they are attached form a 4 to 7 membered, saturated or unsaturated ring, which in addition to the nitrogen atom consists of carbon atoms as ring members, and aryl, aryl-C 1-6 -alkyl, aryloxy and aryl-C 1-6 -alkoxy, wherein the ring moieties optionally may be substituted with one or more substituents selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1-7 -alkanoyl, C 1-6 -alkylthio, C 1-6 -alkylsulfonyl, C 1-6 -alkyl, C 1-6 -alkoxy, C 3-8 -cycloalkyl, trifluoromethyl, trifluoromethoxy, —NR 6 R 7 and —O(C═O)NR 6 R 7 , or wherein two substituents in adjacent positions together form a radical —O—(CH 2 ) 1-3 —O—, wherein R 6 and R 7 independently are hydrogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, C 1-7 -alkanoyl or aryl, or —R 6 and R 7 together with the nitrogen atom to which they are attached form a 4 to 7 membered, saturated or unsaturated ring, which in addition to the nitrogen atom consists of carbon atoms as ring members, with the proviso that the sum of n, o, p and q must be at least 1, as well as any diastereomer or enantiomer or tautomeric form thereof, mixtures of these or a pharmaceutically acceptable salt thereof.