Patent ID: 8455652

Claim:
A compound having a formula: and their pharmaceutically acceptable salts, wherein R 1 is adamantyl; P 1 is a primary pharmacophore selected from the group consisting of —NHC(O)NH—, —OC(O)NH—, and —NHC(O)O—; P 2 is a secondary pharmacophore selected from the group consisting of —C(O)—, —CH(OH)—, —O(CH 2 CH 2 O) q —, —C(O)O—, —OC(O)—, —NHC(O)NH—, —OC(O)NH—, —NHC(O)O—, —C(O)NH— and —NHC(O)—; P 3 is a tertiary pharmacophore selected from the group consisting of C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, aryl, —C(O)NHR 2 , —C(O)NHS(O) 2 R 2 , —NHS(O) 2 R 2 , and —C(O)OR 2 , wherein R 2 is a member selected from the group consisting of hydrogen, substituted or unsubstituted C 1 -C 4 alkyl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted aryl C 1 -C 4 alkyl; the subscripts n and m are each 1, and the subscript q is 0 to 3; L 1 is a first linker selected from unsubstituted C 2 -C 6 alkylene; and L 2 is a second linker selected from the group consisting of substituted and unsubstituted C 2 -C 12 alkylene, substituted and unsubstituted arylene, and combinations thereof.