Patent ID: 7135491

Claim:
A method for treating an inflammation disease in an animal, comprising administering to an animal in need thereof an effective amount of a compound having the formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 1 is —H, —CO 2 R 4 , —C(O)R 5 , or —C(O)N(R 5 )(R 5 ); R 2 is —(C 1 –C 10 )alkyl or —O(C 1 –C 10 )alkyl; R 4 is —(C 5 )heteroaryl, —(C 6 )heteroaryl, phenyl, naphthyl, or benzyl; and each occurrence of R 5 is independently —H, —CF 3 , —(C 1 –C 10 )alkyl, -benzyl, —(C 2 –C 10 )alkenyl, —(C 2 –C 10 )alkynyl, —(C 3 –C 10 )cycloalkyl, —(C 8 –C 14 )bicycloalkyl, or —(C 3 –C 10 )heterocycle, wherein the inflammation is related to or associated with arthritis, psoriasis, gingivitis, colitis, uveitis, diabetes, adult respiratory distress syndrome, autoimmune disease, lupus erythematosus, ileitis, ulcerative colitis, Crohn's disease, asthma, periodontitis, ophthalmitis, endophthalmitis, nephrosis, AIDS-related neurodegeneration, stroke, neurotrauma, Alzheimer's disease, encephalomyelitis, cardiomyopathy, or transplant rejection.