Patent ID: 7919504

Claim:
A compound of Formula V wherein: X is selected from NR 2 or CR 2a R 2b ; R 2 may be absent or is selected from —H, C 1 -C 8 alkyl, —(C 1 -C 6 alkyl)aryl, or —C(O)(C 1 -C 6 alkyl); R 2a and R 2b may both be absent or are independently selected from —H, C 1 -C 8 alkyl, —(C 1 -C 6 )alkyl)aryl, or —C(O)(C 1 -C 6 alkyl); R 3 is selected from —H, C 1 -C 8 alkyl, —C(O)(CR 8 R 9 ) t )N(R 7 ) 2 , —(CR 8 R 9 ) t (aryl), —(CR 8 R 9 ) t (heteroaryl), —(CR 8 R 9 ) t (cycloalkyl), or —(CR 8 R 9 ) t (heterocyclyl); R 4 is selected from —H, C 1 -C 8 alkyl, —(C 1 -C 6 alkyl)aryl, or —C(O)(C 1 -C 6 alkyl); R 5 is selected from —H, —OR 10 , —O—(C 1 -C 6 alkyl)- O—R 10 , C 1 -C 6 alkyl, C 1 -C 6 alkenyl, —(C 1 -C 6 alkyl)-O—R 10 , or —(C 1 -C 6 alkyl)-O—C(O)—R 10 ; R 6 is selected from —H, or C 1 -C 6 alkyl; R 7 is selected from —H, —OR 10 , —O—(C 1 -C 6 alkyl)—O—R 10 , C 1 -C 6 alkyl, C 1 -C 6 alkenyl, —(C 1 -C 6 alkyl)-O—R 10 , or —(C 1 -C 6 alkyl)-O—C(O)—R 10 ; R 8 and R 9 , in each instance, are independently selected from —H, C 1 -C 6 alkyl, or aryl; R 10 is selected from —H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —(C 1 -C 6 alky)aryl, aryl, heteroaryl, C 1 -C 6 hydroxyalkyl, or —(C 1 -C 6 alkyl)-O—(C 1 -C 6 alkyl), cycloalkyl, or heterocyclyl; each t is independently selected from 0, 1, 2, or 3; and Z is selected from aryl or heteroaryl; wherein each of the above alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl moieties and heterocyclic and carbocyclic rings are optionally and independently substituted by 1-3 substituents selected from amino, aryl, heteroaryl, cycloalkyl, or heterocyclyl optionally substituted by 1-5 substituents selected from C 1 -C 6 alkoxy, C 1 -C 6 alkyl optionally substituted by halo, aryl, halo, hydroxyl, heteroaryl, C 1 -C 6 hydroxyalkyl, or —NHS(O) 2 —(C 1 -C 6 alkyl); C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 hydroxyalkoxy, C 1 -C 6 alkylamino, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms, cyano, halo, hydroxyl, nitro, oxo, —NH(CO)—O—(C 1 -C 6 alkyl)aryl, —NH(CO)—O—(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)(CO)—O—(C 1 -C 6 alkyl)aryl, —N(C 1 -C 6 alkyl)(CO)—O—(C 1 -C 6 alkyl), —C(O)OH, —C(O)O(C 1 -C 6 alkyl), —C(O)NH 2 , —C(O)N(H)—(C 1 -C 6 alkyl), —C(O)N(C 1 -C 6 alkyl) 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , —(C 2 -C 4 alkenyl)heterocyclyl, or —(C 2 -C 4 alkenyl)cycloalkyl, or —O—aryl; or a pharmaceutically acceptable salt, stereoisomer, or mixture thereof.