Patent ID: 8188084

Claim:
A compound of formula II: wherein: the sum of a and j is 1 or 2; b is 0, 1, 2 or 3; t is 0,1, 2 or 3; when t is 0 then B is CH 2 ; when t is 1, 2 or 3 then B is CH 2 , NH or O; w is 0, 1, 2 or 3; X is N; each R 1 is independently C 1-6 alkyl, haloC 1-6 alkyl, halogen or cyano; each R 2 is independently hydroxy, halogen, cyano, nitro, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy or NR a R b ; each A is independently a direct bond, O, C═O, (C═O)NR 7 , NR 7 (C═O), (C═O)O, O(C═O), (C═S)NR 7 , NR 7 or S(O) r ; each q is independently 0, 1, 2, 3, or 4; r is 0, 1 or 2; each R 6 is independently hydroxy, cyano, halogen, nitro, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, NR a R b or a ring which is: C 3-10 cycloalkyl; C 6-10 aryl; C 6-10 aryloxy; 4 membered saturated heterocyclic ring containing one N atom; a 5, 6 or 7 membered saturated or partially saturated heterocyclic ring containing one, two or three atoms independently selected from N, O and S; a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S; a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms; or a 7-10 membered unsaturated or partially saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of which rings being optionally substituted by one or more groups independently selected from R 8 ; R 7 is hydrogen or R 6 ; each R 8 is independently hydroxy, oxo, cyano, halogen, nitro, C 1-6 alkyl, C 1-6 alkoxy, C 2-10 alkenyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, —O(C═O)C 1-6 alkyl, —(C═O)OC 1-6 alkyl, NR a R b or a ring which is: C 3-10 cycloalkyl, C 6-10 arylC 1-6 alkyl, C 6-10 arylC 1-6 alkoxycarbonyl, C 6-10 aryl, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S or a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms; any of which rings being optionally substituted by one or more groups independently selected from halogen, C 1-6 alkyl or haloC 1-6 alkyl; each of R 9 and R 10 is independently hydrogen, halogen, C 1-6 alkyl or haloC 1-6 alkyl; each of R a and R b is independently selected from hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-6 alkyl, C 1-6 aryl or C 6-10 arylC 1-6 alkyl; or a pharmaceutically acceptable salt or tautomer thereof.