Patent ID: 6855726

Claim:
A compound according to Formula I or a stereoisomers or pharmaceutically acceptable salts, esters, or amides thereof, wherein: A is selected from CH 2 , CH, C(alkyl); B is selected from H, alkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heteroalkylalkyl, aryl, arylalkyl, heterocycle, heterocycloalkyl, each optionally substituted with R 1 and R 2 ; D is selected from H, alkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heteroalkylalkyl, aryl, arylalkyl, heterocycle, heterocycloalkyl, each optionally substituted with R 1 and R 2 ; E is absent or selected from O, S, NH; F is selected from N or NCH 2 ; G is selected from alkyl, alkyl interrupted by one or more heteroatoms, cycloalkyl, cycloalkyl interrupted by one or more heteroatoms; J is heterocycle optionally substituted with R 1 and R 2 ; K is absent or selected from an alkyl, alkyl interrupted by one or more heteroatoms, cycloalkyl interrupted by one or more heteroatoms, cycloalkylalkyl interrupted by one or more heteroatoms, each optionally substituted with R 1 and R 2 ; L is selected from H, chlorine, fluorine, bromine, iodine, OH, O(alkyl), alkyl, fluoroalkyl, NO 2 , SH, S(O) n (alkyl), SO 3 H, SO 3 alkyl, C(═O)heteroaryl, C(═O)heteroarylalkyl, C(═O)OH, NC(═O)alkyl, NC(═O)aryl, NC(═O)cycloalkyl, NC(═O)cycloalkylalkyl, NC(═O) alkylaryl, R 1 , R 2 ; R 1 is selected from H, C(═NH)NHNH 2 , alkylC(═NH)NHNH 2 , C(═NH)NHOH, alkylC(═NH)NHOH, NHC(═NH)NH 2 , alkylNHC(═NH)NR 2 , C(═S)NH 2 , alkylC(═S)NH 2 , C(═NH)alkyl, alkylC(═NH)alkyl, C(═NR 3 )N(R 4 )(R 5 ), alkylC(═NR 3 )N(R 4 )(R 5 ); R 2 is selected from H, chlorine, fluorine, bromine, iodine, OH, Oalkyl, NC(═O)alkyl, NC(═O)aryl, NC(═O)cycloalkyl, NC(═O)alkylaryl, C(═O)alkyl, C(═O)cycloalkyl. C(═O)cycloalkyl, C(═O)aryl, C(═O)alkyl, C(═O)heteroaryl and C(═O)heteroarylalkyl, NO 2 , SH, S(O) n (C 1-10 alkyl), SO 3 H, SO 3 alkyl, CHO, C(═O)OH, alkyl, C(═NH)alkyl, C(═NH)NHNH 2 , alkylC(═NH)NHNH 2 , C(═NH)NHOH, alkylC(═NH)NHOH, NHC(═NH)NH 2 , alkylNHC(═NH)NHNH 2 , C(═S)NH 2 , alkylC(═S)NH 2 , alkylC(—NH)alkyl, C(═NR 3 )N(R 4 )(R 5 ), alkylC(═NR 3 )N(R 4 )(R 5 ); R 3 , R 4 , and R 5 are a hydrogen atom, alkyl group having 1 to 4 carbon atoms optionally interrupted by a heteroatom, or R 4 and R 5 arc bonded to form —(CH 2 ) p —W—(CH 2 ) q -, wherein p and q are an integer of 2 or 3, a certain position on the methylene chain is unsubstituted or substituted by an alkyl group having 1 to 4 carbon atoms, W is a direct bond, —CH 2 —, —O—, —N(R 6 )—, or —S(O) 2 — wherein R 6 is H or alkyl, and r is 0 or 1 or 2; n is selected from 0, 1, 2; X 1 is C; X 2 is C; X 3 is C; X 4 is C; and --- represents an optional additional bond.