Patent ID: 7691969

Claim:
A crystallized complex of a GRP94 ligand binding domain polypeptide and a ligand, wherein: (a) the GRP94 ligand binding domain polypeptide consists of amino acids 48-316 of SEQ ID NO: 6; (b) the ligand comprises N-ethylcarboxamidoadenosine (NECA); and (c) the crystallized complex has a crystalline form selected from the group consisting of: (i) a crystalline form with unit cell lattice constants of a=99.889 Å, b=89.614 Å, c=60.066 Å; β=90.132°; space group symmetry C2; and 2 GRP94+NECA complexes in the asymmetric unit; and (ii) a crystalline form with lattice constants of a=89.200 Å, b=99.180 Å, c=63.071 Å; α=β=γ=90.0°; space group symmetry C222 (1) ; and 1 GRP94+NECA complex in the asymmetric unit.