Patent ID: 8349326

Claim:
A method for enhancing clearance of a neurotoxin from a subject, the method comprising: administering to the subject a heterodimer binding agent comprising two monomers and two or more copies of a tag, wherein each of the monomers has a binding region, and the binding region of each monomer binds specifically to a different portion of the toxin; and administering to the subject an anti-tag antibody, wherein binding of the anti-tag antibody enhances the clearance of the toxin from the subject, and wherein at least one of the monomers is a VHH antibody having an amino acid sequence selected from the group consisting of: a. an amino acid sequence encoded by a nucleic acid molecule comprising a sequence of SEQ ID NO: 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51 or a combination thereof; and b. an amino acid sequence set forth in SEQ ID NO: 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52 or a combination thereof.