Patent ID: 7132421

Claim:
At least one compound selected from a compound of formula I wherein X 1 and X 2 are each independently selected from the group consisting of hydrogen, —OR 3 , —SR 4 , —NR 5 R 6 , —CONR 5 R 6 , —COOR 7 , halogen, nitro, trifluoromethyl, lower alkyl, lower alkyl substituted by R 8 , cycloalkyl; R 1 is selected from the group consisting of C1–C8 alkyl, C1–C4 alkyl attached to C4–C8 cycloalkyl and C4–C8 cycloalkyl; R 2 is —C═OR 9 ; R 3 is selected from the group consisting of hydrogen, lower alkyl, lower alkyl substituted by R 8 , and cycloalkyl; R 4 is selected from the group consisting of hydrogen and lower alkyl; R 5 and R 6 are each independently selected from the group consisting of hydrogen, lower alkyl and cycloalkyl; or R 5 and R 6 together with the two carbon atoms and the bonds between them from the benzene ring to which they are substituted form a ring selected from a 5- or 6-membered unsaturated ring or a 5- or 6-membered saturated ring that contains at least one hetero atom selected from S, N and O; R 7 is selected from the group consisting of hydrogen, lower alkyl and cycloalkyl; R 8 is selected from the group consisting of —CONR 5 R 6 , —NR 5 R 6 , COOR 7 , aryl, halogen, lower alkoxy, morpholinyl and heterocycles; R 9 is selected from C1–C4 alkyl, —CH═CHCOOH, —NHCH 2 CH 2 R 10 , —N(CH 2 CH 2 OH)CH 2 CH 2 OH, —N(CH 3 )CH 2 CH 2 NCH 3 , —N(CH 3 )CH 2 CH 2 N(CH 3 )CH 3 , saturated 4-, 5- and 6-membered rings, and saturated and unsaturated 5- and 6-membered rings containing at least one hetero atom wherein the hetero atom is selected from S, N and O and being optionally substituted with a group selected from lower alkyl, —C═O—R 11 , —OH, lower alkyl substituted with hydroxy, lower alkyl substituted with —NH 2 , N-lower alkyl, —SO 2 CH 3 , ═O, —CH 2 C═OCH 3 , and 5- and 6-membered saturated rings containing at least one hetero atom selected from S, N and O, R 10 is selected from the group consisting of —N(CH 3 )CH 3 , —NHCH 2 CH 2 NH 2 , —NH 2 , morpholinyl and piperazinyl; and R 11 is selected from H, lower alkyl, —NH 2 , —N-lower alkyl, lower alkyl substituted with hydroxy, and lower alkyl substituted with NH 2 , or a pharmaceutically acceptable salt or ester thereof.