Patent ID: 8912220

Claim:
A compound of formula (I): wherein R 1a and R 2a are each independently selected from H and optionally substituted C 1-8 alkyl; R 3 is selected from H and optionally substituted C 1-8 alkyl; W is optionally substituted arylC 2 -C 6 alkyl, optionally substituted with —OR d , —NR d R d′ , or —C(O)NR d R d′ , optionally substituted arylheteroalkyl, optionally substituted heteroarylheteroalkyl, -alkyl-O—O 0-2 alkyl-aryl, -alkyl-O—C 0-2 alkyl-heteroaryl, —(CH 2 ) 2 —O-phenyl, or is selected from the group: A is optionally substituted C 1-4 alkylene, wherein alkylene is optionally substituted with 1-3 substituents, each of which is independently selected from the group consisting of halogen, oxo, optionally substituted C 1-6 alkyl, —S(O) 0-2 alkyl, —OR d —NR d R d′ , aryl, heteroaryl, C 3 -C 8 cycloalkyl and 4-8 membered heterocycle; R 4 is selected from optionally substituted C 1-8 alkyl, optionally substituted C 1-8 heteroalkyl, C 3-8 cycloalkyl, and cycloalkylalkyl, wherein the alkyl and cycloalkyl are optionally substituted with 1-3 substituents, halo, alkyl, haloalkyl, heteroalkyl, —OR d , —NR d R d′ ; each R 6 is independently selected from halo, C 1-8 alkyl, aryl, heteroaryl, heteroalkyl, C 3-8 cycloalkyl, heterocyclyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkyl, —SH, —OR d , C 1-8 haloalkoxy, C 1-8 haloalkyl, —S(O) 0-2 C 1-8 alkyl, —S(O) 0-2 aryl, —S(O) 0-2 heteroaryl, —S(O) 0-2 arylalkyl, —S(O) 0-2 heteroarylalkyl, —S(O) 0-2 cycloalkyl, —S(O) 0-2 heterocycloalkyl, —S(O) 0-2 heterocycloalkylalkyl, —S(O) 0-2 cycloalkylalkyl, —OC(O)NR d R d′ , —NR d C(O)NR d′ R d″ , —NR d C(O)OR a , —NR d S(O) 2 alkyl, —NR d S(O) 2 aryl, —NR d S(O) 2 heteroaryl, —NR d S(O) 2 cycloalkyl, —NR d S(O) 2 heterocycloalkyl, —NR d S(O) 2 —C 1-4 alkyl-aryl, —NR d S(O) 2 -heteroarylalkyl, —NR d S(O) 2 -cycloalkylalkyl, —NR a S(O) 2 -heterocycloalkyl, —SO 2 NR d R d′ , cyano, nitro, C 1-6 haloalkyl, C 1-6 haloalkoxy, —NR d R d′ , —C 1-4 alkyl-NR d R d′ , optionally substituted C 1-6 alkyl, —NR d C(O)R a , —C(O)NR d R d′ , and —C(O)OR d ; wherein alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl are optionally substituted; each R a is independently selected from optionally substituted C 1-8 alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3-8 cycloalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl and optionally substituted heterocycloalkyl; R d , R d′ , and R d″ are each independently selected from H and R a , or when taken together with the atom to which they are attached, two of R d , R d′ and R d″ form a 4-8 membered heterocyclic moiety; and g is 1, 2 or 3.