Patent ID: 8840933

Claim:
A method of reducing the volume of lesion due to a spinal cord injury or a traumatic brain injury in a subject in need thereof, the method comprising: a) delivering to the subject a first injectable composition comprising magnesium chloride and 20-30% weight/volume of polyethylene glycol (PEG) in saline, wherein said magnesium chloride and PEG act synergistically to treat the injury; b) providing the dose of Mg in said magnesium chloride to be within a range from 0.115 to 0.230 mmol of Mg/kg of the subject's weight and providing the dose for PEG to be within a range from 0.7 to 1.4 g of PEG/kg of the subject's weight for the first injectable composition; c) delivering to the subject a second injectable composition comprising magnesium chloride and 20-30% weight/volume of PEG in saline within 24 hours of delivering the first injectable composition wherein said magnesium chloride and PEG act synergistically to treat the injury; d) providing the dose of Mg in said magnesium chloride to be within a range from 0.115 to 0.230 mmol of Mg/kg of the subject's weight and the dose for PEG to be within a range from 0.7 to 1.4 g of PEG/kg of the subject's weight for the second injectable composition; and e) observing at least 29% improvement in lesion volume over a similar dosage of Mg administered alone in saline due to the synergistic effect of co-administering Mg and PEG.