Patent ID: 8252783

Claim:
A process of preparing a fluoroquinolone having formula I or a salt or ester thereof, the process comprising: (a) contacting a first compound having Formula II with a second compound having Formula III to produce a crude product comprising a mixture including a fluoroquinolone having Formula I, wherein said fluoroquinolone, the first compound, and the second compound are represented by wherein R 1 is selected from the group consisting of hydrogen, C 1 -C 5 substituted and unsubstituted alkyl groups, C 3 -C 10 cycloalkyl groups, C 6 -C 14 substituted and unsubstituted aryl groups, and C 5 -C 14 substituted and unsubstituted heteroaryl groups; R 2 is selected from the group consisting of unsubstituted amino group and amino groups substituted with one or two C 1 -C 5 alkyl groups; R 3 is selected from the group consisting of hydrogen, C 1 -C 5 substituted and unsubstituted alkyl groups, C 3 -C 10 cycloalkyl groups, C 1 -C 5 substituted and unsubstituted alkoxy groups, C 5 -C 14 substituted and unsubstituted aryl groups, C 5 -C 14 substituted and unsubstituted heteroaryl groups, and C 5 -C 14 substituted and unsubstituted aryloxy groups; X and W are independently selected from the group consisting of Cl, F, and Br; Y is selected from the group consisting of CH 2 , O, S, SO, SO 2 , and NR 4 , wherein R 4 is selected from the group consisting of hydrogen, unsubstituted lower alkyl groups, substituted lower alkyl groups, and cycloalkyl groups; and Z is selected from the group consisting of oxygen and two hydrogen atoms; (b) contacting the crude product with an aqueous medium to produce an aqueous mixture; and (c) recovering said fluoroquinolone having Formula I from said aqueous mixture.