Patent ID: 8003660

Claim:
A compound of formula Ie: or a pharmaceutically acceptable salt thereof, wherein: R 1 is a branched or straight C 1-12 aliphatic optionally substituted with 1-3 of R A , wherein up to 3 carbon units of R 1 are optionally and independently replaced by —CONR F —, —O—, —NR F CO—, or —S—; Each R A is halo, —OH, —NH 2 , —NO 2 , —CN, or —OCF 3 ; Each R F is hydrogen, or a branched or straight C 1-8 aliphatic group optionally substituted with 1-3 of R A ; R 2a is —Z B R 5 , wherein each Z B is independently a bond or an optionally substituted branched or straight C 1-4 aliphatic chain wherein up to two carbon units of Z B are optionally and independently replaced by —CO—, —CS—, —CONR B —, —CONR B NR B —, —CO 2 —, —OCO—, —NR B CO 2 —, —O—, —NR B CONR B —, —OCONR B —, —NR B NR B —, —NR B CO—, —S—, —SO—, —SO 2 —, —NR B —, —SO 2 NR B —, —NR B SO 2 —, or —NR B SO 2 NR B —; Each R 5 is independently R B , halo, —OH, —CN, or —OCF 3 ; Each R B is independently hydrogen, an optionally substituted C 1-8 aliphatic group, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, or R 2a and R 3 together with the atoms to which they are attached form a 5-7 membered partially unsaturated optionally substituted cyclic group optionally having 1-2 heteroatoms independently selected from N, O, and S; Each R 2b is hydrogen, fluoro or methyl; or R 2a and one R 2b together with the atoms to which they are attached form a 5-7 membered partially unsaturated optionally substituted cyclic group optionally having 1-2 heteroatoms independently selected from N, O, and S, wherein R 2b is attached to a carbon atom vicinal to the carbon atom to which R 2a is attached on the fused phenyl of formula I, or Two of R 2b together with the atoms to which they are attached form a 5-7 membered partially unsaturated optionally substituted cyclic group optionally having 1-2 heteroatoms independently selected from N, O, and S, wherein each R 2b is attached to a vicinal carbon atom on the fused phenyl of formula Ie; one of R 3 and R′ 3 is hydrogen and the other of R 3 and R′ 3 is independently —Z C R 6 , wherein each Z C is independently an optionally substituted branched or straight C 1-4 aliphatic chain wherein up to two carbon units of Z C are optionally and independently replaced by —CO—, —CS—, —CONR C —, —CONR C NR C —, —CO 2 —, —OCO—, —NR C CO 2 —, —O—, —NR C CONR C —, —OCNR C —, —NR C NR C —, —NR C CO—, —S—, —SO—, —SO 2 —, —SO 2 NR C —, —NR C SO 2 —, or —NR C SO 2 NR C —; Each R 6 is independently R C , halo, —OH, —NH 2 , —NO 2 , —CN, or —OCF 3 ; Each R C is independently hydrogen, an optionally substituted C 1-8 aliphatic group; an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl having 1-3 heteroatoms R 4 and R′ 4 are each independently hydrogen or fluoro; m is 2, p is 2; n is 0-2; and q is 0-3.