Patent ID: 7030113

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt or solvate thereof, wherein the dashed line in represents either (i) an optional bond which may be present or absent, and if present, forms a double bond with the single bond it is adjacent to, or (ii) —C(R 5 R 8 )—, —C(R 5 R 8 )—C(R 5 R 8 )— or —C(R 11 R 12 )—; m is 1, 2, 3 or 4; n is 0, 1 or 2; p is 0, 1 or 2; Ar is aryl, heteroaryl, R 4 -substituted aryl or R 4 -substituted heteroaryl; Z is —NR 5 R 6 , —NR 5 C(O)R 3 , —C(O)NR 5 R 6 , —NR 5 C(O)NR 5 R 6 , —NR 5 C(O)OR 3 , —NR 5 S(O 2 )R 3 , —S(O 2 )NR 5 R 6 , —S(O 2 )R 3 , —C(O)R 3 , —C(O)OR 6 , —OH, alkoxy, R 1 is 1 to 4 moieties, each R 1 is independently selected from the group consisting of hydrogen, —OH, halogen, alkyl, alkoxy, —OCF 3 , —CF 3 or —CN, or two R 1 moieties on adjacent carbons of the cycloalkyl ring can be joined together to form a methylenedioxy or ethylenedioxy group; R 2 is hydrogen, alkyl, R 10 -substituted alkyl, cycloalkyl, R 10 -substituted cycloalkyl, aralkyl, heterocyclyl, —C(O)R 3 , —S(O 2 )R 3 or —C(O)NR 5 R 6 ; R 3 is alkyl, aryl, aralkyl, heteroaryl, R 4 -substituted aralkyl, R 4 -substituted aryl or R 4 -substituted heteroaryl; R 4 is 1 to 5 moieties, each R 4 is independently selected from the consisting of hydrogen, heterocyclyl, R 9 -substituted heterocyclyl, heterocyclylalkyl-, R 9 -substituted heterocyclylalkyl, —OH, -alkoxy, —OCF 3 , —CN, alkyl, halogen, —NR 5 R 6 , —NR 5 C(O)R 7 , —C(O)NR 5 R 6 , —NR 5 S(O 2 )R 7 , —S(O 2 )NR 5 R 6 , —S(O 2 )R 7 , —COR 7 , —C(O)OR 5 , —CF 3 , -(alkylene)NR 5 R 6 , -(alkylene)NR 6 C(O)R 7 , -(alkylene)NR 6 S(O 2 )R 7 , -(alkylene), —NR 5 C(O)NR 5 R 6 , -(alkylene)NR 5 C(O)OR 7 , CHO, —C═(NOR 5 ) and R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, aryl, aralkyl or heteroaryl; R 7 is alkyl, aryl, aralkyl or heteroaryl; R 8 is hydrogen or alkyl; R 9 is alkyl, —OH or hydroxyalkyl; R 10 is alkoxy, halogen, —C(O)NR 5 R 6 , —C(O)OR 6 , —NR 5 R 6 or —OH; R 11 is hydrogen or halogen; and R 12 is hydrogen or halogen.