Patent ID: 8080571

Claim:
A compound of formula I, wherein A represents —CH 2 —, —C(O)—, —C(O)—CH 2 — or —CH 2 —CH 2 —; one of X 1 and X 2 represents —N— and the other represents —C(R 1 )—; X 3 represents —N— or —C(R 2 )—; X 4 represents —N— or —C(R 3 )—; R 1 , R 2 and R 3 independently represent H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl, Ar 1 , Het 1 , C 1-3 alkyl-Ar 2 , C 1-3 alkyl-Het 2 , C 1-3 alkoxy-Ar 3 , C 1-3 alkoxy-Het 3 , halo, —C(O)—C 1-6 alkyl, —C(O)—Ar 4 or —C(O)—Het 4 ; or R 2 and R 3 may be linked to form, along with the carbon atoms to which they are attached, a 5- or 6-membered aromatic ring optionally containing one to three heteroatoms; Ar 1 , Ar 2 , Ar 3 and Ar 4 each independently represent a C 6-10 aryl group, which group is optionally substituted by one or more substituents selected from ═O, —OH, cyano, halo, nitro, C 1-6 alkyl (optionally terminated by —N(H)C(O)OR 11a ), C 1-6 alkoxy, phenyl, —N(R 12a )R 12b , —C(O)R 12c , —C(O)OR 12d , —C(O)N(R 12e )R 12f , —N(R 12g )C(O)R 12h , —N(R 12i )C(O)N(R 12k , —N(R 12m )S(O) 2 R 11b , —S(O) n R 11c , —OS(O) 2 R 11d ; and —S(O) 2 N(R 12n )R 12p ; Het 1 , Het 2 , Het 3 and Het 4 each independently represent a four- to twelve-membered heterocyclic group containing one or more heteroatoms selected from oxygen, nitrogen and/or sulfur, which heterocyclic group is optionally substituted by one or more substituents selected from ═O, —OH, cyano, halo, nitro, C 1-6 alkyl (optionally terminated by —N(H)C(O)OR 11a ), C 1-6 alkoxy, phenyl, —N(R 12a )R 12b , —C(O)R 12c , —C(O)OR 12d , —C(O)N(R 12e )R 12f , —N(R 12g )C(O)R 12h , —N(R 12i )C(O)N(R 12j )R 12k , —N(R 12m )S(O) 2 R 11b , —S(O) n R 11c , —OS(O) 2 R 11d ; and —S(O) 2 N(R 12n )R 12p ; R 11a to R 11d independently represent C 1-6 alkyl; R 12a to R 12p independently represent H or C 1-6 alkyl; n represents 0, 1 or 2; Y 1 , Y 2 , Y 3 and Y 4 independently represent —CH— or —CF—; Z 1 represents —CH—, —O—, —S—, —N— or —CH═CH—; Z 2 represents —CH—, —O—, —S— or —N—; provided that: (a) Z 1 and Z 2 are not the same; (b) when Z 1 represents —CH═CH—, then Z 2 may only represent —CH— or —N—; and (c) other than in the specific case in which Z 1 represents —CH═CH—, and Z 2 represents —CH—, when one Z 1 and Z 2 represents —CH—, then the other represents —O— or —S—; R 4 represents —S(O) 2 N(H)C(O)R 6 , —S(O) 2 N(H)S(O) 2 R 6 , —C(O)N(H)S(O) 2 R 6 , or, when Z 1 represents —CH═CH—, R 4 may represent —N(H)S(O) 2 N(H)C(O)R 7 or —N(H)C(O)N(H)S(O) 2 R 7 ; R 5 represents C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl or di-C 1-3 -alkylamino-C 1-4 -alkyl; R 6 represents C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl, C 1-3 alkoxy-C 1-6 -alkoxy, C 1-6 alkylamino or di-C 1-6 alkylamino; and R 7 represents C 1-6 alkyl, or a pharmaceutically-acceptable salt thereof.