Patent ID: 6846820

Claim:
A compound of Formula (I) and the pharmaceutically acceptable salts and prodrugs thereof wherein the dotted line (---) is an optional bond; A is —C(H)═, —C((C 1 -C 4 )alkyl)═or —C(halo)═when the dotted line (---) is a bond, or A is methylene or —CH((C 1 -C 4 )alkyl)- when the dotted line (---) is not a bond; R 1 , R 10 or R 11 are each independently H, halo, 4-, 6- or 7-nitro, cyano, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, fluoromethyl, difluoromethyl or trifluoromethyl; R 2 is H; R 3 is H or (C 1 -C 5 )alkyl; R 4 is pyridazine-3- or -4-yl(C 1 -C 4 )alkyl, pyrimidine-2-, -4- or -5- or -6-yl(C 1 -C 4 )alkyl, or pyrazine-2- or -3-yl (C 1 -C 4 )alkyl, wherein said preceding R 4 heterocycles are optionally mono- or di-substituted indepenently with halo, trifluoromethyl, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, amino or hydroxy and said mono- or di-substituents are bonded to carbon; R 5 is H, hydroxy, fluoro, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 6 )alkanoyl, amino(C 1 -C 4 )alkoxy, mono-N— or di-N,N—(C 1 -C 4 )alkylamino (C 1 -C 4 )alkoxy, carboxy(C 1 -C 4 )alkoxy, (C 1 -C 5 )alkoxy-carbonyl(C 1 -C 4 )alkoxy, benzyloxycarbonyl C 1 -C 4 alkoxy, or carbonyloxy wherein said carbonyloxy is carbon-carbon linked with phenyl, and wherein said preceding R 5 ring is optionally mono-substituted with halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, hydroxy, amino or trifluoromethyl; R 7 is H, fluro or (C 1 -C 5 )alkyl; or R 5 and R 7 can be taken together to be oxo; R 6 is carboxy, (C 1 -C 8 )alkoxycarbonyl, C(O)NR 8 R 9 or C(O)R 12 , wherein R 8 is H, (C 1 -C 3 )alkyl, hydroxy or (C 1 -C 3 )alkoxy; and R 9 is pyridazinyl, pyrimidinyl, pyrazinyl, or piperazinyl, wherein said non-aromatic preceding R 9 ring is carbon-nitrogen linked; or R 9 is mono- or di-substituted (C 1 -C 5 )alkyl, wherein said substituents are independently pyridazinyl, pyrimidinyl, pyrazinyl, or piperazinyl wherein the non-aromatic nitrogen-containing R 9 rings are optionally mono-substituted on nitrogen with (C 1 -C 6 )alkyl, benzyl, benzoyl or (C 1 -C 6 )alkoxycarbonyl and wherein the R 9 rings are optionally mono-substituted on carbon with halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, hydroxy, amino or mono-N— and di-N,N—(C 1 -C 5 )alkylamino provided that no quaternized nitrogen is included and there are no nitrogen-oxygen, nitrogen-nitrogen or nitrogen-halo bonds; R 12 is piperazine-1yl, 4-(C 1 -C 4 )alkylpiperazin-1-yl, or 4-formylpiperazin-1-yl; or R 12 is 3-, 4- and/or 5-mono-, di- or tri-substituted piperazin-1-yl wherein said R 12 substituents are independently H, halo, (C 1 -C 5 )alkyl, hydroxy, amino, mono-N— or di-N,N(C 1 -C 5 )alkylamino, formyl, oxo, hydroxyimino, (C 1 -C 5 )alkoxy, carboxy, carbamoyl, mono-N— or di-N,N(C 1 -C 4 )alkylcarbamoyl, (C 1 -C 4 )alkoxyimino, (C 1 -C 4 )alkoxymethoxy, (C 1 -C 6 )alkoxycarbonyl, carboxy (C 1 -C 5 )alkyl, or hydroxy (C 1 -C 5 )alkyl.