Patent ID: 8232295

Claim:
A method of treating a vascular disorder associated with increased PAR-1, PAR-4 or both in an individual, wherein the method comprises: a) selecting an individual diagnosed with a vascular disorder characterized by having an elevated G-coupled Protease Activating Receptor (PAR)-1 level, an elevated PAR-4 level, or both; b) administering to said individual an amount of a statin, wherein the statin is administered in an amount between 5 mg and 250 mg to thereby inhibit PAR-1, PAR-4 or both; and c) detecting in said individual the level of PAR-1, PAR-4 or both and comparing said level to step a); wherein the statin reduces the PAR-1 level, the PAR-4 level or both, as compared to the level prior to step b), to thereby treat the vascular disorder.