Patent ID: 8278297

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein Y is O or NR 9 ; R 1 is aryl or 5-14 membered heteroaryl having 1-3 heteroatoms independently selected from N, O, or S, either of which is optionally substituted with 1-3 substituents independently selected from alkyl, halo, amino, alkoxy, haloalkyl, alkylsulfonyl, nitro, phenyl, piperazinyl, or alkylpiperazin-1-yl; R 2 is H, alkyl, or cycloalkyl; each of R 3 and R 4 is independently H, alkyl, cycloalkyl, aryl, or 5-14 membered heteroaryl having 1-3 heteroatoms independently selected from N, O, or S; or R 3 and R 4 , together with the carbon atom to which they are attached, form a cycloalkyl; each of R 5 and R 6 is independently H, alkyl, cycloalkyl, aryl, or 5-14 membered heteroaryl having 1-3 heteroatoms independently selected from N, O, or S; R 7 is H, alkyl, cycloalkyl, aryl, 5-14 membered heteroaryl having 1-3 heteroatoms independently selected from N, O, or S, or 3-14 membered heterocyclyl having 1-3 heteroatoms independently selected from N, O, or S; R 8 is alkyl optionally substituted with halo, —OH, or alkoxy; R 9 is H or alkyl; or R 2 and R 9 , together with the atoms to which they are attached, form a 5- to 8-membered monocyclic ring containing additional 0 to 2 heteroatoms each independently selected from O, N, and S, wherein said monocyclic ring is optionally substituted with 0 to 4 groups each independently being alkyl, halo, alkoxy, or hydroxy; and q is 0 or 1, Provided that when q is 0, then Y is NR 9 , and R 2 and R 9 , together with the atoms to which they are attached, form a 5- to 8-membered monocyclic ring containing additional 0-2 hetero atoms each independently selected from O, N, and S, wherein said monocyclic ring is optionally substituted with 0 to 4 groups each independently being halo or alkyl.