Patent ID: 7772192

Claim:
A method of treating disease in a mammalian subject comprising administering a therapeutically effective amount of a composition comprising a pharmaceutically-acceptable carrier and a disaccharide inhibitor of glycosyltransferase comprising the structure: sugar-X-sugar-Y—R, wherein: the sugars are glucose, galactose, N-acetylglucosamine, glucosamine, N-acetylgalactosamine, galactosamine, sialic acid, fucose or mannose; X is a bridging atom, O, C, S, or N, and wherein X is a 1-2, 1-3, 1-4, or 1-6 linkage with anomeric configuration, α or β, between the sugars; Y is a bridging atom, O, C, S, or N, with anomeric configuration, α or β; R is a benzyl, phenyl, naphthol, naphthalenemethanol, an indenol, an alkyl group of 1-16 carbons, or a polyisoprenoid; and wherein, independently, the sugar is O-alkyl, O-acyl, or O-aryl substituted for a hydroxyl group; the sugar is alkyl-, aryl-, epoxy-, amid-, thiol- or halo-substituted for a hydroxyl group; or the sugar is S-alkyl, N-alkyl, S-acyl, N-acyl, C-acyl, S-aryl, or N-aryl substituted for a hydroxyl group; wherein the disease is a cancer selected from the group consisting of lung cancer, breast cancer, colon cancer, gastric cancer, prostate cancer and melanoma.