Patent ID: 8466179

Claim:
A method for making a pharmaceutical composition for intravenous administration comprising: providing an aqueous solution comprising a tonicity agent, a buffer, and at least one active ingredient selected from the group consisting of nicardipine and/or pharmaceutically acceptable salts thereof; adjusting the pH of the aqueous solution as necessary to achieve a pH within the range of from about 3.6 to 4.7; further diluting the aqueous solution to a final active ingredient concentration from about 0.1 to 0.4 mg/mL; and filling pharmaceutically acceptable containers with the aqueous solution such that the solution is in contact with non-polar polymers, the aqueous solution when stored in the container for at least three months at room temperature exhibiting (i) less than a 10% decrease in the concentration of nicardipine or pharmaceutically acceptable salt thereof and (ii) a total impurity formation of less than about 3%.