Patent ID: 8357777

Claim:
A pharmaceutical composition to elicit an immune response comprising an isolated antigen and a carrier, wherein one or more amino acids in said antigen have been chemically modified to introduce αGal epitopes with compounds of structure αGal-N(CH 3 )—O—R 1 —COOR 2 , wherein αGal is a trisaccharide of formula Galα1-3Galβ1-4Glc or Galα1-3Galβ1-4GlcNAc, wherein R 1 is any linear or branched alkyl group of 1 to 30 carbon atoms, wherein one or more carbon atoms in said alkyl group can be substituted by O, S, or N and wherein one or more hydrogens can be substituted by hydroxyl, carbonyl, alkyl, sulphydryl or amino groups, and wherein R 2 is an amino or sulphydryl reacting group.