Patent ID: 8906919

Claim:
A method for the treatment or amelioration of non-neuronal and non-myocardial cell or tissue damage or death, comprising administering to a mammal in need thereof a therapeutically effective amount of a persistent sodium current blocker or a pharmaceutically acceptable salt thereof; wherein the non-neuronal and non-myocardial cell or tissue damage or death occurs in skeletal muscle tissue, smooth muscle tissue, connective tissue or epithelial tissue; and wherein the persistent sodium current blocker is selected from the group consisting of lidocaine, mexiletine, lamotrigine, BW1003C87 ([5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine 1.1 ethanesulphonate]), sipatrigine, phenytoin, fosphetrytoin, riluzole, flunarizine, CP-060S ((−)-(S)-2-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-3-[3-[N-methyl-N-[2-(3,4-methylenedioxy-phenoxy)ethyl]amino]propyl]-1,3-thiazolidin-4-one hydrogen fumarate), R56865 (N-[1-(4-(4-fluorophenoxy)butyl)]-4-piperidinyl-N-methyl-2-benzo-thiazolamine), flecainide, azure A, and F15845 (3-(R)-[3-(2-methoxyphenylthio-2-(S)-methyl-propyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine bromohydrate) or a pharmaceutically acceptable salt thereof.