Patent ID: 7098211

Claim:
A compound of formula II or a pharmaceutically acceptable equivalent, an isomer or a mixture of isomers thereof, wherein: R 2 and R 3 are independently —COOR 7 , nitro, cyano or trifluoromethyl; R 7 is C 1 –C 8 alkyl, C 2 –C 8 alkenyl or C 2 –C 8 alkynyl, wherein the alkyl, alkenyl or alkynyl is optionally substituted with C 1 –C 4 alkoxy or —NR 5 R 6 ; R 4 is hydrogen, halo, nitro, cyano, trifluoromethyl, amino, —NR 5 R 6 , C 1 –C 4 alkoxy, C 1 –C 4 alkylthio, C 1 –C 8 alkyl, C 2 –C 8 alkenyl or C 2 –C 8 alkynyl, wherein one or more —CH 2 — group(s) of the alkyl, alkenyl or alkynyl is/are optionally replaced with —O—, —S—, —SO 2 — and/or —NR 5 —, and the alkyl, alkenyl or alkynyl is optionally substituted with one or more oxo(s) and/or hydroxyl(s); R 5 and R 6 are independently hydrogen, C 1 –C 8 alkyl, C 2 –C 8 alkenyl or C 2 –C 8 alkynyl, wherein the alkyl, alkenyl or alkynyl is optionally substituted with phenyl or substituted phenyl; L is a direct bond, C 1 –C 12 alkylene, C 2 –C 12 alkenylene or C 2 –C 12 alkynylene, wherein one or more —CH 2 — group(s) of the alkylene, alkenylene or alkynylene is/are optionally replaced with —O—, —S—, —SO 2 — and/or —NR 5 —, and the alkylene, alkenylene or alkynylene is optionally substituted with one or more oxo(s) and/or hydroxyl(s); and X is a moiety of formula J or Q with X connected to L through any one R; each R is independently a direct bond connecting X to L, hydrogen, halo, nitro, cyano, trifluoromethyl, amino, —NR 5 R 6 , C 1 –C 4 alkoxy, C 1 –C 4 alkylthio, —COOR 7 , C 1 –C 12 alkyl, C 2 –C 12 alkenyl or C 2 –C 12 alkynyl, wherein one or more —CH 2 — group(s) of the alkyl, alkenyl or alkynyl is/are optionally replaced with —O—, —S—, —SO 2 — and/or —NR 5 —, and the alkyl, alkenyl or alkynyl is optionally substituted with one or more oxo(s) and/or hydroxyl(s), wherein only one R may be a direct bond connecting X to L; and Ar is an aryl that is optionally substituted in 1 to 3 position(s) with halo, nitro, cyano, trifluoromethyl, amino, —NR 5 R 6 , C 1 –C 4 alkoxy, C 1 –C 4 alkylthio, —COOR 7 , C 1 –C 8 alkyl, C 2 –C 8 alkenyl or C 2 –C 8 alkynyl, wherein one or more —CH 2 — group(s) of the alkyl, alkenyl or alkynyl is/are optionally replaced with —O—, —S—, —SO 2 — and/or —NR 5 —, and the alkyl, alkenyl or alkynyl is optionally substituted with one or more oxo(s) and/or hydroxyl(s).