Patent ID: 8664367

Claim:
A binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein: VD1 is a first heavy chain variable domain; VD2 is a second heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; and n is independently 0 or 1; and wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein: VD1 is a first light chain variable domain; VD2 is a second light chain variable domain; C is a light chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 does not comprise an Fc region; and n is independently 0 or 1; wherein, in said first polypeptide chain, VD1 comprises the amino acid sequence of SEQ ID NO: 204; and VD2 comprises the amino acid sequence of SEQ ID NO: 213; wherein, in said second polypeptide chain, VD1 comprises the amino acid sequence of SEQ ID NO: 238; and VD2 comprises the amino acid sequence of SEQ ID NO: 216; and wherein the binding protein binds human IL-1β and human IL-1α.