Patent ID: 7144728

Claim:
A method of inducing anergic T helper cells which comprises: a) incubating antigen presenting cells (APC) with allospecific T suppressor cells (Ts); b) overexpressing in the APC mRNA which encodes at least one monocyte inhibitory receptor (MIR), wherein the MIR is ILT4 (MIR-10), ILT2 (MIR7) or ILT3, in a mixture of cells comprising the APCs from step (a), wherein overexpression of the MIR transmits negative inhibitory signals to recruit an inhibitory signaling molecule, tyrosine phosphate SHP-1 such that the APC are rendered tolerogenic; and c) isolating and further incubating the APCs from step (b) with T helper cells (Th) to induce Th anergy.