Patent ID: 7232838

Claim:
A compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein L is 3-pyridyl or 4-pyridyl; Q is C 3-6 cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, each of said rings optionally being substituted with up to three substituents each independently selected from halo; hydroxy; cyano; carboxyl; azido; amino; mono- or di(C 1-6 alkyl)amino; C 1-6 alkylcarbonylamino; C 1-6 alkyl; C 2-6 alkenyl; C 2-6 alkynyl; C 3-6 cycloalkyl; C 1-6 alkyl substituted with hydroxy, C 1-6 alkyloxy, amino or mono- or di(C 1-4 alkyl)amino; C 1-6 alkyloxy; C 1-6 alkylthio; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; arylC 1-6 alkyloxy; aryloxy; polyhaloC 1-6 alkyl; polyhalo-C 1-6 alkyloxy; polyhaloC 1-6 alkylcarbonyl; Het; C 1-4 alkyl-S(═O) n —or R 1 HN—S(═O) n —; or Q is a radical of formula and wherein Z is halo; C 1-6 alkyl; C 1-6 alkylcarbonyl; aminocarbonyl; C 1-6 alkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with C 1-4 alkyl substituted piperidinyl, mono- or di(C 1-6 alkyl)amino, aminocarbonyl, mono- or di(C 1-6 alkyl)aminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxy, piperidinyl, piperazinyl, morpholinyl or thiomorpholinyl; polyhaloC 1-4 alkyl; cyano; amino; mono- or di(C 1-6 alkyl)aminocarbonyl; C 1-6 alkyloxycarbonyl; C 1-6 alkylcarbonyloxy; amino-S(═O) 2 —; mono- or di(C 1-6 alkyl)amino-S(═O) 2 or —C(═N—R x )NR y R z ; R x is hydrogen, C 1-6 alkyl, cyano, nitro or —S(═O) 2 — NH 2 ; R y is hydrogen, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; R z is hydrogen or C 1-4 alkyl. r is an integer from 1 to 3; q is an integer from 1 to 4; X and Y are each independently O, NR 3 , CH 2 or S, with R 3 being hydrogen or C 1-4 alkyl; W is O or NR 4 , with R 4 being hydrogen or C 1-4 alkyl; aryl is phenyl, optionally substituted with up to five substituents each independently selected from halo, hydroxy, C 1-6 alkyl, polyhaloC 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkythio, cyano, nitro, amino or mono-or di(C 1-6 alky)amino; and Het is a monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle wherein each of said ring systems may optionally be substituted with up to 3 substituents, each substituent independently being selected from halo; hydroxy; amino; cyano; carboxyl; mono-or di(C 1-6 alkyl)amino: C 1-6 alkyl; C 1-6 alkyl substituted with hydroxy, C 1-4 alkyloxy, amino or mono-or di(C 1-4 alkyl)amino; polyhaloC 1-6 alkyl; C 1-6 alkyloxy; C 1-6 alkylthio; C 1-6 alkyloxycarbonyl; C 1-6 alkylcarbonyloxy; aminocarbonyl, mono-or di(C 1-6 alkyl)aminocarbonyl; C 1-6 alkyl-C(=O)-NH-; C 1-6 alkyloxy- C(=O)-NH-; H 2 N-C(=O)-NH- or mono- or di(C 1-4 alkyl)amino-C(=O)-NH-.