Patent ID: 8703947

Claim:
A compound of the formula (III) or a pharmaceutically acceptable salt thereof; wherein a is optionally substituted methylene or C(O), and b is O, S(O), S(O) 2 , or NR 6 ; Q 1 is a divalent carbocycle, heterocycle, unsaturated heterocycle, aryl, or heteroaryl, each of which is optionally substituted; X 2 is NR 1 , C(O), S(O), S(O) 2 , NR 1 —C(O), NR 1 —S(O), NR 1 —S(O) 2 , optionally substituted alkylene, or optionally substituted alkylenoxy; X 3 is C(O), S(O), S(O) 2 or CHR 1 ; R is heteroaryl, aryl, heteroarylalkyl or arylalkyl, each of which is optionally substituted; X 1 is optionally substituted alkylene; A is O or NR 1 ; or A is a nitrogen atom, and A and X 1 are taken together to form an optionally substituted heterocycle; R 1 is independently selected in each instance from hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted; R 2 , R 3 , and R 4 are in each instance hydrogen; R 5 is alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted; R 6 is hydrogen, OR 7 , S(O)R 7 , S(O) 2 R 7 , C(O)R 8 , C(O)OR 7 , C(O)NR 9 R 10 , S(O)NR 9 R 10 , S(O) 2 NR 9 R 10 , alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted; R 7 is in each instance independently selected from the group consisting of alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, each of which is optionally substituted; R 8 is in each instance independently selected from hydrogen, or selected from the group consisting of alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, each of which is optionally substituted; R 9 and R 10 are in each instance independently selected from hydrogen, or selected from the group consisting of alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, alkylsulfonyl, arylsulfonyl, and heteroarylalkyl, each of which is optionally substituted; or R 9 and R 10 and the attached nitrogen form an optionally substituted heterocycle; and R 11 is hydrogen, or R 11 is alkyl, alkenyl, heteroalkyl, alkoxyl, thioalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted.