Patent ID: 7112684

Claim:
A compound having a formula selected from the group consisting of: wherein R 1 and R 1′ are each members independently selected from the group consisting of H, halogen, cyano, halo(C 1 –C 8 )alkyl, (C 1 –C 8 )alkyl, (C 1 –C 8 )alkylthio, (C 1 –C 8 )alkoxy, aryl and heteroaryl; each R 5 and R 6 is independently selected from the group consisting of H, (C 1 –C 8 )alkyl, aryl, heteroaryl, aryl(C 1 –C 4 )alkyl and heteroaryl(C 1 –C 4 )alkyl; wherein the alkyl portions of any of R 1 , R 1′ , R 5 and R 6 are optionally substituted with halogen, carboxy, sulfo, amino, mono- or dialkylamino, alkoxy, cyano, haloacetyl or hydroxy, and the alkyl portions of the substituents have from 1 to 6 carbon atoms; and the aryl or heteroaryl portions of any of R 1 , R 1′ , R 5 and R 6 are optionally substituted with from one to four substituents selected from the group consisting of halogen, cyano, carboxy, sulfo, hydroxy, amino, mono- or di(C 1 –C 6 )alkylamino, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkylthio and (C 1 –C 6 )alkoxy; R A and R B are combined to form a substituted or unsubstituted fused ring system having from 1 to 4 five- or six-membered rings; R x is selected from the group consisting of H and hydroxy protecting groups; the subscript p is an integer of from 1 to 3; W is a di-, tri- or tetravalent linker which is acyclic, cyclic, aromatic or a combination thereof, having from 4 to 50 atoms selected from the group consisting of C, N, O, P and S and exclusive of hydrogen atoms that fill available valences, and further having a nitrogen atom directly connected to the adjacent carbonyl group; K is selected from the group consisting of H, OH, SH, NH, (C 1 –C 8 )alkyl, aryl, an amino protecting group and a hydroxy protecting group or is absent when W is O or S; the subscript n is 0 or 1; and when n is 1, Y is a cleavable linking group and L is a solid support; and when n is 0, L is a phosphoramidite or reactive functional group; and tautomeric forms thereof.