Patent ID: 7022699

Claim:
A compound of the formula: R 1 and R 2 are, independently, selected from hydrogen, (C 1 –C 6 )lower alkyl, halogen, cyano, trifluoromethyl, hydroxy, amino, (C 1 –C 6 ) lower alkylamino, (C 1 –C 6 ) lower alkoxy, —OCF 3 , (C 1 –C 6 ) lower alkoxycarbonyl, —NHCO[lower alkyl], carboxy, —CONH 2 , —CONH (C 1 –C 6 ) lower alkyl, or —CON[(C 1 –C 6 ) lower alkyl] 2 ; R 3 is a substituent selected from hydrogen, (C 1 –C 6 ) lower alkyl, (C 1 –C 6 ) lower alkoxy, hydroxy, amino, (C 1 –C 6 ) lower alkylamino, —CO lower alkyl (C 1 –C 6 ), or halogen; R 4 consists of the moiety B-C; wherein B is selected from the group of wherein: A is CH or N; R 5 , R 6 , R 7 and R 8 are independently, selected from hydrogen, (C 1 –C 6 ) lower alkyl, (C 1 –C 6 ) lower alkoxy, hydroxy (C 1 –C 6 ) lower alkyl, alkoxy (C 1 –C 6 ) lower alkyl, acyloxy (C 1 –C 6 ) lower alkyl, (C 1 –C 6 ) lower alkylcarbonyl, (C 3 –C 6 ) lower alkenyl, (C 3 –C 6 ) lower alkynyl, (C 3 –C 8 ) cycloalkyl, formyl, cycloalkylcarbonyl, carboxy, alkoxycarbonyl, cycloalkyloxycarbonyl, aryl alkyloxycarbonyl, carbamoyl, —O—CH 2 —CH═CH 2 , halogen, halo lower alkyl, trifluoromethyl, —OCF 3 , —S(lower alkyl), —OC(O)N[lower alkyl] 2 , —CONH(lower alkyl), —CON[lower alkyl] 2 , lower alkylamino, di-lower alkylamino, lower alkyl di-lower alkylamino, hydroxy, cyano, trifluoromethylthio, nitro, amino, lower alkylsulfonyl, aminosulfonyl, lower alkylaminosulfonyl, naphthyl, phenyl, or R 9 is chosen from the group of hydrogen, (C 1 –C 6 ) lower alkyl, hydroxy (C 1 –C 6 ) lower alkyl, alkoxy (C 1 –C 6 ) lower alkyl, acyloxy (C 1 –C 6 ) lower alkyl, alkoxycarbonyl, —CON[(C 1 –C 6 ) lower alkyl] 2 , cyano; or aryl, optionally substituted by halogen, or lower alkoxy; R 10 represents one to two substituents chosen independently, from the group of hydrogen, (C 1 –C 6 ) lower alkyl, hydroxy (C 1 –C 6 ) lower alkyl, alkoxy (C 1 –C 6 ) lower alkyl, acyloxy (C 1 –C 6 ) lower alkyl, [(C 1 –C 6 ) lower alkyl] 2 , carbonyl, azido, amino, —NH[lower alkyl], —N[lower alkyl] 2 , amino carbonyl lower alkyl, phthalimido, cyano, halogen, thio lower alkyl, aryloxy, arylthio, aryl optionally substituted with one to three substituents chosen from (C 1 –C 6 ) lower alkyl, alkoxy or halogen; hydroxy, lower alkoxy, —OSO 2 R 12 , or OP′ wherein P′ is tert-butyl dimethylsilyl, tert-butyl diphenylsilyl, carbonyl loweralkyl, carbonyl trifluoro lower alkyl, aryl lower alkyl, arylcarbonyl, methoxymethyl, or methylthiomethyl; with the proviso that when R 10 represents two substituents, the two substituents may be joined together to form with the cyclohexene ring to which they are attached a bicyclic system selected from the group consisting of bicyclo[3.2.1]oct-2-ene and (6,6-dimethyl)-bicyclo[3.1.1]hept-2-ene; R 11 is selected from the group of hydrogen, or (C 1 –C 6 ) lower alkyl; R 12 is selected from the group of (C 1 –C 6 ) lower alkyl, trifluoro lower alkyl, or aryl optionally substituted by halogen or lower alkyl; or a pharmaceutically acceptable salts form thereof.