Patent ID: 6906060

Claim:
A compound of the general formula (I): wherein n is 1, 2 or 3, R 1a and R 1b independently are hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl or fluoro, R 2 is hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl or C 3-8 -cycloalkenyl, X is R 3a , R 3b , R 3c and R 3d independently are hydrogen, halogen, C 1-6 -alkyl or C 3-8 -cycloalkyl, or R 3a and R 3b , R 3a and R 3c , or R 3b and R 3d can be taken together to form a C 1-6 -alkylene bridge, R 4 , R 5 , R 6 and R 7 independently are hydrogen, halogen, C 1-6 -alkyl or C 3-8 -cycloalkyl, Z is R 8 , R 9 , R 10 , R 11 and R 12 independently are hydrogen, cyano, nitro, halogen, carboxy, guanidino, or amidino, C 1-6 -alkyl, C 1-6 -alkoxy, C 2-6 -alkenyl, C 2-6 -alkynyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylsulfinyl, C 1-6 -alkylthio, C 1-6 -alkylcarbonyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkylcarbonyl, C 3-8 -cycloalkenyl, aryl, arylsulfonyl, arylsulfinyl or arylthio, each of which may optionally be substituted with one or more groups selected from cyano, nitro, halogen, carboxy, guanidino, amidino, trifluoromethyl, trifluoromethoxy, —NR 13 R 14 , —NHC(═O)R 15 or —C(═O)NR 13 R 14 , —NR 13 R 14 , —NHC(═O)R 15 , —OC(═O)NR 13 R 14 , —NHC(═O)OR 16 or —C(═O)NR 13 R 14 , or R 8 and R 9 , R 9 and R 10 , R 10 and R 11 , or R 11 and R 12 can be taken together to form a bridge selected from C 1-6 -alkylene, —O—(CH 2 ) o —O— and —O—(CH 2 ) o —, o is 1, 2, 3, 4 or 5, R 13 , R 14 and R 15 independently are hydrogen or aryl, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl or C 3-8 -cycloalkenyl, each of which may optionally be substituted with one or more groups selected from cyano, nitro and halogen, R 16 is aryl, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl or C 3-8 -cycloalkenyl, each of which may optionally be substituted with one or more groups selected from cyano, nitro and halogen, as well as any diastereomer or enantiomer or tautomeric form thereof or mixtures of these or a pharmaceutically acceptable salt thereof.