Patent ID: 7001729

Claim:
A method for identifying an agent that binds to an adenine nucleotide translocator (ANT) polypeptide, comprising: contacting a candidate agent with a host cell expressing a recombinant ANT polypeptide having at least 95% identity to an ANT polypeptide selected from the group consisting of human ANT1; as set forth in SEQ ID NO:31, human ANT2, as set forth in SEQ ID NO:32, and human ANT3; as set forth in SEQ ID NO:33, under conditions and for a time sufficient to permit binding of the agent to said recombinant polypeptide, wherein the host cell comprises a recombinant expression construct comprising at least one regulated promoter operably linked to a nucleic acid encoding the recombinant ANT polypeptide; and detecting binding of said agent to the recombinant ANT polypeptide.