Patent ID: 7541352

Claim:
A compound of formula I where: R 1 is CO 2 R 6 or CONR 7 R 8 ; R 2 is COR 12 , COCOR 13 , SO 2 N(R 14 )(R 15 ), or SO 2 R 16 ; R 3 is hydrogen or alkyl; R 4 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 5 is cycloalkyl; R 6 is hydrogen or alkyl; R 7 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 ) 2 NSO 2 , or (R 10 )SO 2 ; R 8 is hydrogen or alkyl; R 9 is hydrogen or alkyl; R 10 is azetidinyl, pyrrolidinyl, piperidinyl, N—(R 11 )piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, N—(R 11 )homopiperazinyl, or homomorpholinyl; R 11 is hydrogen or alkyl; and R 12 is amino, alkylamino, or dialkylamino; or R 12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from alkyl, alkoxy, and phenyl wherein phenyl is substituted with 0-3 substituents selected from cyano, halo, alkyl, and alkoxy; or R 12 is R 13 is hydroxy, alkoxy, amino, alkylamino, or dialkylamino; or R 13 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from alkyl, alkoxy, and phenyl wherein phenyl is substituted with 0-3 substituents selected from cyano, halo, alkyl, and alkoxy; or R 13 is R 14 is hydrogen, or alkyl; R 15 is hydrogen or alkyl; R 16 is alkyl, cycloalkyl, or haloalkyl; or R 16 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from alkyl, alkylcarbonyl, alkoxycarbonyl, benzyl, and benzyloxycarbonyl; or R 16 is phenyl substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; R 17 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, benzyl, alkylcarbonyl, alkoxycarbonyl, benzyloxycarbonyl, alkylSO 2 , or pyridinyl; and X is absent, a bond, or methylene; or a pharmaceutically acceptable salt thereof.