Patent ID: 7429661

Claim:
A process for the preparation of 5-aminomethyl substituted oxazolidinones of formula I: wherein X is O, S, SO or SO 2 ; R 1 is H, CH 3 or CN; R 2 is independently H, F or Cl; R 3 is H or CH 3 ; n is 0, 1 or 2; which comprises; a) (i) reacting the compound of formula II: wherein R 1 , R 3 , X, R 2 and n are as defined in formula I; with potassium phthalimide of formula III: to produce compounds of formula IV: wherein R 1 , R 3 , X, R 2 and n are as defined in formula I; (or) ii) reacting the compound of formula V: wherein R 1 , R 3 , X, R 2 and n are as defined in formula I; with phthalimido oxiranyl compound of formula VI: b) converting the product of step (a) to produce a compound of formula VII: and c) converting the product of step (b) to aminomethyl oxazolidinone of formula I.