Patent ID: 8026236

Claim:
A 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivative having the general Formula I wherein R 1 is H or (C 1-3 )alkyl; R 2 is H or (C 1-3 )alkyl; R 3 is halogen or (C 1-4 )alkyl, optionally substituted with one or more halogens; X is CH 2 , O or S; n is 1-3; Y is selected from NR 4 COR 5 , NR 4 SO 2 R 5 , R 4 is H, (C 1-3 )alkyl or (C 3-5 )cycloalkyl; R 5 is H, (C 1-6 )alkyl, (C 3-5 )cycloalkyl, NR 12 R 13 , CR 16 R 17 NR 12 R 13 , Het or a saturated 4-6-membered NR 11 containing ring; R 6 is (C 3-5 )cycloalkyl, halo(C 1-6 )alkyl,(C 1-3 )alkyloxy(C 1-3 )alkyl, (CH 2 ) m CONR 12 R 13 , CO(C 1-6 )alkyl, COCR 16 R 17 NR 12 R 13 , SO 2 (C 1-6 )alkyl, Het, COHet or CH 2 Het; r=0-3; p=0-2; q=0-2; X 1 and X 2 are independently CH or N; one of R 7 and R 8 is selected from halogen, (C 1-3 )alkyloxy, NR 14 R 15 , CONR 14 R 15 , NR 14 COR 15 , COO(C 1-3 )alkyl and phenyl; the other is H or halogen; R 9 and R 10 are (C 1-3 )alkyl; or R 9 an R 10 form together with the carbon to which they are bonded a 3-5 membered saturated ring; R 11 is H or (C 1-3 )alkyl; m is 0 or 1; Het is a 5- or 6 membered heteroaryl ring comprising 1-3 heteroatoms selected from O, S and N, optionally substituted with (C 1-3 )alkyl; R 12 and R 13 are independently H, (C 1-6 )alkyl, or (C 1-3 )alkyloxy(C 1-3 )alkyl; or R 12 and R 13 form together with the N to which they are bonded a 5-10 membered saturated heterocyclic ring, optionally comprising a further heteroatom selected form O and S; R 14 and R 15 are independently H or (C 1-6 )alkyl; or R 14 and R 15 form together with the N to which they are bonded a 5-7 membered saturated heterocyclic ring; R 16 and R 17 are independently H or (C 1-3 )alkyl; or R 16 and R 17 form together with the carbon atom to which they are bonded a cyclopropyl ring; with the proviso that when r is 0, R 6 is not H or (C 1-4 )alkyl, or a pharmaceutically acceptable salt thereof.