Patent ID: 7960372

Claim:
The compound having Formula II: wherein: A 1 and A 1 ′ are independently selected from the group consisting of hydrogen, CH 3 , CH 2 CH 2 OH, cycloalkyl, and alkyl; A 2 and A 2 ′ are independently selected from the group consisting of hydrogen, CH 2 CH 2 OH, cycloalkyl, alkyl, and COR 1 , wherein A 2 is absent when V is O and A 2 ′ is absent when V′ is O; V and V′ are independently selected from the group consisting of N, CH and O; W and W′ are independently selected from the group consisting of CH and N; X and X′ are independently C 1-3 alkyl, or Y and Y′ are independently selected from the group consisting of CONR 1 , C(O)O, (CR 1 R 2 ) 1-3 , wherein one or more CH 2 groups can be replaced by O, S, aryl, or NR 1 ; D and D′ are independently selected from the group consisting of alkylenyl and (CR 1 R 2 ) n —R 5a —(CR 3 R 4 ) m ; J and J′ are independently selected from the group consisting of alkylenyl and (CR 1 R 2 ) p —R 5b —(CR 3 R 4 ) q ; T and T′ are independently selected from the group consisting of C═O, C═S, C═NR 1 , S, O, NR 1 , CR 1 R 2 , and aryl; U and U′ are independently selected from the group consisting of hydrogen, NR 1 R 2 , OR 1 , SR 1 , alkyl and aryl; n, m, p and q are independently 0-5; each R 1 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted carbocyclic, optionally substituted heterocyclic, optionally substituted aryl, optionally substituted heteroaryl and Z; each R 2 , R 3 and R 4 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted carbocyclic, optionally substituted heterocyclic, optionally substituted aryl and optionally substituted heteroaryl, R 5a and R 5b are independently selected from the group consisting of CO═C═S, C═NR 1 , S, O, NR 1 and CR 1 R 2 ; and Z is a linker covalently linking one of A 1 , Y, D, J, T and U with one of A 1 ′, Y′, D′, J′, T′ and U; or pharmaceutically acceptable salts.