Patent ID: 7919627

Claim:
A process for preparing a compound of formula (I): wherein R 1 and R 2 are each independently selected from: (a) hydrogen; and (b) NH 2 ; or one of R 1 or R 2 is hydrogen and the other is selected from: (a) C(O)R 3 , where R 3 is C 1 -C 6 alkyl, optionally substituted with one or more substituents selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; (b) C(O)OR 3 , where R 3 is as previously defined; and (c) wherein A and B are each independently hydrogen, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted cyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alicyclic group, or a substituted or unsubstituted heteroaryl group or A and B taken together with the carbon to which they are attached form a cyclic moiety selected from: aryl, substituted aryl, heterocyclic, substituted heterocyclic, alicyclic, or substituted alicyclic alternatively, R 1 and R 2 are taken together with the nitrogen atom to which they are attached to form N═C(R 4 )(R 5 ), where R 4 and R 5 are each independently selected from a substituted or unsubstituted aliphatic group, a substituted or unsubstituted cyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alicyclic group, or a substituted or unsubstituted heteroaryl group; said process comprising: (1) reacting pyrazole with (6-chloro-pyridin-3-yl)-methanol in the presence of: (a) an acid catalyst; (b) a neat organic acid; or (c) a transition metal catalyst and base; to form a compound of formula III (2) halogenating the compound of formula III with a chlorinating reagent to provide a compound of formula (VI): (3) reacting a compound of the formula R 1 R 2 NOH, with the compound of formula VI to form a compound of formula I: