Patent ID: 8709732

Claim:
A method of diagnosing an early onset of gastric cancer in a subject, the method comprising the steps of: (a) detecting in a sample from a subject suspected of having an early onset of gastric cancer at least 3-fold over-expression of at least one first protein biomarker selected from the group consisting of albumin, high molecular weight kininogen, α-2-HS glycoprotein, α-1-antitrypsin, afamin and γ-actin; (b) detecting in the sample from the subject suspected of having an early onset of gastric cancer at least 3-fold under-expression of at least three second protein biomarkers selected from the group consisting of stress 70 protein, apolipoprotein A-I, apolipoprotein A-IV, transthyretin, and α2-macroglobulin; and (c) identifying the subject as having an early onset of gastric cancer upon detecting the at least one first protein biomarker being at least 3-fold over-expressed in the sample when compared to the expression of the same at least first protein biomarker in a control sample and upon detecting at least one of the three second protein biomarkers being at least 3-fold under-expressed in the sample when compared to the expression of the same second protein biomarker in a control sample.