Patent ID: 7816407

Claim:
A method of treating, ameliorating, or preventing seizures associated with epilepsy in a subject in need thereof, the method comprising: administering a pharmaceutical composition comprising about 0.1 to about 500 mg of agmatine or an agmatine analog, or a pharmaceutically acceptable salt thereof per kilogram of the subject's weight to treat, reduce, or prevent seizures associated with epilepsy in the subject, wherein the agmatine analog has the following formula wherein n is 0 to about 10; R 1 , R 2 , R 3 , R 4 , and R 5 , are each independently, or any combination thereof: hydrogen, hydroxy, substituted or unsubstituted C 1-10 alkyl, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted arylalkyl (comprising Ar—(CH 2 ) m ; where Ar is aromatic and m is 0 to about 10) substituted or unsubstituted C 1-10 alkoxyl, substituted or unsubstituted C 1-10 acyl, halogeno, amido, phenyl, thio, or amino; and X and Y are each independently: O, NH, CH 2 , CF 2 , Se, C═O, C═N, or C═S, or X—Y together is HC═CH, C≡C, N═N, N═CH, CH═N, or a saturated or unsaturated ring.