Patent ID: 8492555

Claim:
A crystalline salt of the compound isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester, wherein said crystalline salt consists of: 1 equivalent of compound isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester; 2 equivalents of maleic acid; and 0 equivalents of water; characterised by the presence of peaks in the X-ray powder diffraction diagram at the following angles of refraction 2θ: 10.15°, 20.39°, and 22.63°; wherein said X-ray powder diffraction diagram is obtained by using Cu Kα1 radiation; and the accuracy of the 2θ values is in the range of 2θ+/−0.2°; or said crystalline salt consists of: 1 equivalent of isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester; an acid component consisting of 1.5 equivalents of fumaric acid; and 0 to 5 equivalents of water. characterised by the presence of peaks in the X-ray powder diffraction diagram at the following angles of refraction 2θ: 5.27°, 8.05°, and 20.61°; wherein said X-ray powder diffraction diagram is obtained by using Cu Kα1 radiation; and the accuracy of the 2θ values is in the range of 2θ+/−0.2°, or said crystalline salt consists of: 1 equivalent of isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester; an acid component consisting of 2 equivalents of hydrobromic acid; and 0 to 5 equivalents of water; characterised by the presence of peaks in the X-ray powder diffraction diagram at the following angles of refraction 2θ: 9.3°, 15.6°, and 17.3°; wherein said X-ray powder diffraction diagram is obtained by using Cu Kα1 radiation; and the accuracy of the 2θ values is in the range of 2θ+/−0.2°.