Patent ID: 8129426

Claim:
A method of treating lupus erythematosus or rheumatoid arthritis, comprising administering to a subject in need of same an effective amount of a water-soluble artemisinin compound of the following formula: wherein, n=0 or 1; and when n=0, X and Y are H, and Z is NH 2 ; when n=1, X is OH, Y is H, and Z is NH 2 , NHMe, NHEt, NHPr(n), NHBu, NHCH 2 CH 2 OH, when n=1, X is OH, Y is CH 3 or phenyl, and Z is NH 2 , NHR, NHCH 2 CH 2 OH, NR′ 2 , NH(CH 2 ) 2-3 NMe 2 , wherein R and R′ are independently C1-C4 alkyl, and the stereoisomers, optical isomers, and pharmaceutically acceptable salts thereof.