Patent ID: 7105562

Claim:
A compound of the Formula: wherein A, B, D and E are each carbon; R 1 and R 6 are each H; R 2 , R 3 , R 4 , R 5 and R 7 are each independently selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, trihaloalkyl, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, —SOR 13 , —SO 2 R 13 , —SO 2 NR 13 R 14 , R 14 SO 2 N(R 13 )—, N-trihalomethanesulfonamido, —C(O)R 15 , —C(O)OR 15 , R 15 C(O)O—, cyano, nitro, halo, cyanato, isocyanato, isocyanato, thiocyanato, isothiocyanato, —OC(O)NR 13 R 14 , R 14 OC(O)NR 13 —, —OC(S)NR 13 R 14 , R 14 OC(S)NR 13 —, —C(O)NR 13 R 14 , R 14 C(O)NR 13 — and —NR 13 R 14 ; R 8 is selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, trihaloalkyl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, —SOR 13 , —SO 2 R 13 , —SO 2 NR 13 R 14 , R 14 SO 2 N(R 13 )—, N-trihalomethanesulfonamido, —C(O)R 15 , —C(O)OR 15 , R 15 C(O)O—, cyano, nitro, halo, cyanato, isocyanato, isocyanato, thiocyanato, isothiocyanato, —OC(O)NR 13 R 14 , R 14 OC(O)NR 13 —, —OC(S)NR 13 R 14 , R 14 OC(S)NR 13 —, —C(O)NR 13 R 14 , R 14 C(O)NR 13 — and —NR 13 R 14 ; R 13 and R 14 are each independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylaryl, arylalkyl, heteroaryl, heteroalicyclic, —C(O)R 15 , acetyl, —SO 2 R 15 and —(CH 2 ) n NR 13 R 14 ; R 15 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl and heteroalicyclic; R 9 , R 10 , R 11 and R 12 are each independently selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, trihaloalkyl, halo, cyano, hydroxy, alkoxy, aryloxy, alkylthio, arylthio, —SO 2 R 15 , —S(O)R 15 , —(CH 2 ) n C(O)OR 15 , cyanato, isocyanato, thiocyanato, isothiocyanato, —C(O)NR 13 R 14 , R 14 C(O)NR 13 — and —NR 13 R 14 ; n is an integer from 0 to 20; and X is nitrogen; or a prodrug or pharmaceutically acceptable salt thereof.