Patent ID: 8633323

Claim:
A method of preparing a bis(thio-hydrazide amide) represented by formula (I): or a tautomer, pharmaceutically acceptable salt, or prodrug thereof, wherein: R 13 is a covalent bond, or a substituted or unsubstituted C1-C6 alkylene group; R 1 and R 2 are independently an optionally substituted aryl or an optionally substituted heteroaryl; R 3 and R 4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl; R 5 and R 6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl; R 40 is an optionally substituted aryl or an optionally substituted heteroaryl; and R 41 is —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl; comprising a) reacting a compound of formula (V): with S 8 , DMF and a compound of formula (VI): b) deprotecting the resulting compound; and c) coupling the deprotected compound obtained in step b) to obtain a compound of formula (I).