Patent ID: 7645792

Claim:
A method for treating migraine, nausea, vomiting, anxiety, seizures, convulsions, trauma of the central nervous system, and neurodegenerative conditions of Friedrich's disease, Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Pick disease in a patient, comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound according to the structural Formula (I), or pharmaceutically acceptable salts thereof: wherein: each R 1 and R 2 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, or substituted arylalkyl, or optionally, R 1 and R 2 together with the carbon atom to which they are bonded form a cycloalkyl or substituted cycloalkyl ring; A is hydrogen or [H 2 NCHR 5 C(O)]—, and R 5 is hydrogen, C 1-6 alkyl, substituted C 1-6 alkyl, C 5-7 aryl, substituted C 5-7 aryl, C 6-11 arylalkyl, substituted C 6-11 arylalkyl, C 1-6 heteroalkyl, substituted C 1-6 heteroalkyl, C 5-7 heteroaryl, substituted C 5-7 heteroaryl, C 6-11 heteroarylalkyl, or substituted C 6-11 heteroarylalkyl or optionally, R 5 and the alpha amino group together with the atoms to which they are bonded form a C 5-7 cycloheteroalkyl or substituted C 5-7 cycloheteroalkyl ring; Y is —O— or —NR 3 —; R 3 is hydrogen, alkyl, substituted alkyl, arylalkyl or substituted arylalkyl; n is an integer from 1 to 5; X is —NR 4 —, —O—, —CH 2 — or —S—; and R 4 is hydrogen, alkyl, substituted alkyl, arylalkyl or substituted arylalkyl; wherein each substituent is halogen, —NH 2 , —OH, —CN, —COOH, —C(O)NH 2 , C(O)OR 7 or —NR 7 3 + , and each R 7 is independently C 1-3 alkyl.