Patent ID: 8343490

Claim:
An isolated antibody which binds Colo205 and directly induces cell death without the need for immune effector cells, wherein the antibody binding domain of the heavy chain comprises CDR1, CDR2 and CDR3 and wherein the sequence of CDR1 of the antibody binding domain is amino acids 44 to 54 or 49 to 54 of SEQ ID NO: 23 and the sequence of CDR2 of the antibody binding domain is amino acids 69 to 84 of SEQ ID NO: 23 and the sequence of CDR3 of the antibody binding domain is amino acids 117 to 127 of SEQ ID NO: 23 and wherein the antibody binding domain of the light chain comprises CDR1, CDR2 and CDR3 and the sequence of CDR1 of the antibody binding domain is amino acids 46 to 55 of SEQ ID NO: 27 and the sequence of CDR2 of the antibody binding domain is amino acids 71 to 77 of SEQ ID NO: 27 and the sequence of CDR3 of the antibody binding domain is amino acids 110 to 118 of SEQ ID NO: 27.