Patent ID: 8148410

Claim:
A compound of the Formula (I) wherein A represents wherein the asterisks indicate the bond that is linked to the thiophene group of Formula (I); R 1a represents C 1-5 -alkyl, C 3-5 -cycloalkyl, or 2-hydroxyethyl; R 1b represents hydrogen or C 1-3 -alkyl; or R 1a and R 1b , together with the nitrogen to which they are attached, form an azetidine, a pyrrolidine, a piperidine, or a morpholine ring; R 2 represents hydrogen or C 1-2 -alkyl; R 3 represents hydrogen or C 1-2 -alkyl; R 4 represents hydrogen, C 1-2 -alkyl, methoxy, or halogen; R 5 represents hydrogen, C 1-4 -alkyl, or C 1-4 -alkoxy; R 6 represents hydroxy-C 1-4 -alkyl, di-(hydroxy-C 1-4 -alkyl)-C 1-4 -alkyl, 2,3-dihydroxypropyl, —CH 2 —(CH 2 ) n —NR 61 R 62 , —CH 2 —(CH 2 ) n —NHCOR 64 , —CH 2 —(CH 2 ) n —NHSO 2 R 63 , —CH 2 —CH 2 —COOH, —CH 2 —CH 2 —CONR 61 R 62 , 1-(3-carboxy-azetidinyl)-3-propionyl, 1-(2-carboxy-pyrrolidinyl)-3-propionyl, 1-(3-carboxy-pyrrolidiny)-3-propionyl, —CH 2 —CH(OH)—CH—CH 2 —NR 61 R 62 , —CH 2 —CH(OH)—CH 2 —NHCOR 64 , —CH 2 —CH(OH)—CH 2 —NHSO 2 R 63 , —CO—NHR 61 , hydroxy, hydroxy-C 2-4 -alkoxy, di-(hydroxy-C 1-4 -alkyl)-C 1-4 -alkoxy, 2,3-dihydroxypropoxy, 2-hydroxy-3-methoxy-propoxy, —OCH 2 —(CH 2 ) m —NR 61 R 62 , —OCH 2 —(CH 2 ) m —NHCOR 64 , —OCH 2 —(CH 2 ) m —NHSO 2 R 63 , 2-[(azetidine-3-carboxylic acid)-1-yl]-ethoxy, 2-[(pyrrolidine-2-carboxylic acid)-1-yl]-ethoxy, 2-[(pyrrolidine-3-carboxylic acid)-1-yl]-ethoxy, —OCH 2 —CH(OH)—CH 2 —NR 61 R 62 , —OCH 2 —CH(OH)—CH 2 —NHCOR 64 , —OCH 2 —CH(OH)—CH 2 —NHSO 2 R 63 , 3-[(azetidine-3-carboxylic acid)-1-yl]-2-hydroxypropoxy, 2-hydroxy-3-[(pyrrolidine-2-carboxylic acid)-1-yl]-propoxy, 2-hydroxy-3-[(pyrrolidine-3-carboxylic acid)-1-yl]-propoxy, —NR 61 R 62 , —NHCO—R 64 , or —SO 2 NH—R 61 ; R 61 represents hydrogen, methyl, ethyl, 2-hydroxyethyl, 2-hydroxy-1-hydroxymethyl-ethyl, 2,3-dihydroxy-propyl, 2-C 1-2 -alkoxyethyl, 3-hydroxypropyl, 2-aminoethyl, 2-(C 1-14 -alkylamino)ethyl, 2-(di-(C 1-4 -alkyl)amino)ethyl, carboxymethyl, (C 1-4 -alkylcarboxy)methyl, 2-carboxyethyl, or 2-(C 1-4 -alkylcarboxy)ethyl; R 62 represents hydrogen or methyl; R 63 represents methyl, ethyl, methylamino, ethylamino, or dimethylamino; R 64 represents hydroxymethyl, 2-hydroxyethyl, aminomethyl, methylaminomethyl, dimethylaminomethyl, 2-aminoethyl, or 2-methylamino-ethyl; m represents the integer 1 or 2; n represents 0, 1, or 2; and R 7 represents hydrogen, C 1-2 -alkyl, or halogen; or a salt of such a compound.