Patent ID: RE42275

Claim:
The A compound or pharmaceutically acceptable salt thereof, of the formula, wherein each n is independently 1, 2, 3, 4, 5 or 6; each R 1 and R 2 are independently —C(O)OR 3 , —C(O)N (R 3 ) 2 , —P(O)(OR 3 ) 2 , —OP(O)(OR 3 ) 2 , —S(O) 2 R 3 , —S(O) 2 OR 3 , —S(O) 2 N(R 3 ) 2 , or tetrazolyl; each R 3 is independently —H or C 1 -C 6 alkyl; R 4 is —H, —C(O)OR 3 , —C(O)N(R 3 ) 2 , —P(O)(OR 3 ) 2 , —OP(O)(OR 3 ) 2 , —S(O) 2 R 3 , —S(O) 2 OR 3 , —S(O) 2 N (R 3 ) 2 , or tetrazolyl; L is —P(O)(OR 3 )—, or —P(O)(N(R 3 ) 2 )—; M is —O—, —S—, —N( R 3 )—, or —CH 2 —; M and T are independently T is —O—, —S—, or —N(R 3 )— , or —CH 2 —; ; R 10 is —H, —C 1 -C 6 alkyl, aryl, —C 1 -C 6 alkyl-aryl, -aryl-aryl, —X—R 6 , —R 7 , —C(O)R 5 , —S(O) 2 R 5 , peptide, dendrimer, or peptide dendrimer, wherein X is —O—, —S—, or —N(R 3 )—; R 5 is —CH(R 51 )N(R 52 ) 2 ; C 1 -C 6 alkyl optionally substituted with 1 to 3 groups which are independently -halogen, COOR 53 , or —N(R 52 ) 2 ; aryl; or heteroaryl, wherein R 51 is —H, aryl, heteroaryl, C 1 -C 6 alkyl-aryl optionally substituted with —OH; C 1 -C 6 alkyl-heteroaryl, or C 1 -C 6 alkyl optionally substituted with —OR 53 , —SR 53 , —NH 2 , —N(H)C(═NH)NH 2 , —COOR 53 , or —C(O)N(R 53 ) 2 ; and R 52 is —H, C 1 -C 6 alkyl, —C(O)R 53 , C(O)OR 53 , —C(O)NH(C 1 -C 6 alkyl), —C(O)N(R 53 ) 2 , —C(O) aryl, or —C(O)heteroaryl; R 53 is —H, C 1 -C 6 alkyl, or C 1 -C 6 alkyl-aryl; R 6 is —H or C 1 -C 6 alkyl; and R 7 is —L 1 —R 8 , wherein L 1 is —C(O)N(R 3 )—, —C(S)N(R 3 )—, —C(O)CH (R 21 )—, —C(O)(O), or —C(O)—L 2 —, wherein R 21 is —H, aryl, heteroaryl, C 1 -C 6 alkyl-aryl optionally substituted with —OH; C 1 -C 6 alkyl-heteroaryl, or C 1 -C 6 alkyl optionally substituted with —OR 23 , —SR 23 , —NH 2 , —N(H)C(═NH)NH 2 , —COOR 23 , or —C(O)N(R 23 ) 2 ; and R 23 is —H, C 1 -C 6 alkyl, or C 1 -C 6 alkyl-aryl; L 2 is —C 1 -C 24 alkyl- or -phenyl-C 1 -C 24 alkyl-, wherein each alkyl group is optionally substituted with 1 to 4 groups which are oxo, ═S, or —COOH; and one to six of the methylene groups in each alkyl group is optionally replaced by —O—, —S—, or —N(R 3 )—, provided that no two adjacent methylene groups are both replaced by —O—, —S—, or —N(R 3 )—; and R 8 is —H, —NH 2 , or —OH; and Q is —O—, —S—, —N(R 3 )—, —N(R 3 )O—, —ON (R 3 )—, —CH 2 —, or ═NO—.