Patent ID: 6995143

Claim:
A compound of the formula wherein R 1 is —Y—X—Q; Y is S, SO, SO 2 , H 3 , CH 2 O, or CO; X is a bond or a linear group with up to 9 atoms selected from the group consisting of C, N, O and S, of which up to 2 atoms can be N, one atom can be O or S, one carbon atom can appear as a CO group, one sulfur atom can appear as an SO 2 group and two adjacent C atoms can be present as —CH═CH— or —C≡C—; Q is hydrogen, alkyl, heterocyclyl or aryl, which heterocyclyl and aryl groups may be further substituted; R 2 is hydrogen or fluorine; R 3 is methyl, —(CH 2 ) 3 —R 5 , —CH 2 CH═CH—R 5 or —CH 2 C≡C—R 5 ; R 5 is heterocyclyl or aryl, which heterocyclyl and aryl groups may be further substituted; Z is O or NOR 4 ; R 4 is hydrogen, alkyl, heterocyclyl, aryl, heterocyclyl alkyl or aralkyl; * indicates a chiral centre which is in the (R) or (S) form, and/or pharmaceutically acceptable acid addition salts or in vivo cleavable esters thereof, provided that not simultaneously R 2 is hydrogen, R 3 is methyl and Z is O when simultaneously R 1 is —S(L) m R 6 , —S(O)(L) m R 6 , or —S(O) 2 (L) m R 6 ; L represents —(CH 2 ) n — or —(CH 2 )nZ 1 (CH 2 ) n′ —; m is 0 or 1; n is 1, 2, 3, or 4; N′ is 0, 1, 2, 3, or 4; Z 1 is O, S or NH; and R 6 is hydrogen, alkyl, heterocyclyl or aryl; which heterocyclyl and aryl groups may be further substituted.