Patent ID: 7625905

Claim:
A compound according to formula I wherein R 1 is selected from the group consisting of (a) phenyl, (b) pyridinyl, (c) pyrimidinyl, each optionally substituted with C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, hydroxy, cyano, NHSO 2 C 1-6 alkyl, SO 2 NR 9a R 10a , —NR 9b R 10b , and halogen, and (d) B1 wherein R 8 is C 3-7 cycloalkyl, phenyl or heteroaryl selected from the group consisting of pyridine, pyrimidine, pyrazine and pyridazine said heteroaryl or said phenyl optionally substituted with C 1-3 alkyl or C 1-3 haloalkyl; One of R 2 and R 3 is hydrogen and the other of R 2 and R 3 is A1, A2 or A3, or R 2 and R 3 together are (CH 2 ) m NR 4 (CH 2 ) n wherein m and n are independently one or two; R 4 is C 1-6 alkyl, C 1-6 haloalkyl, CH 2 C≡N, —C(═O)R 5 or —SO 2 R 5 ; R 5 is (a) C 1-6 alkyl, (b) C 3-6 cycloalkyl optionally independently substituted with one or two C 1-6 alkyl, halogen, hydroxy, cyano, oxo or C 1-6 haloalkyl, (c) C 1-6 haloalkyl, (d) C 1-6 hydroxyalkyl, (e) C 1-3 alkoxy-C 1-3 alkyl, (f) C 3-6 cycloalkyl-C 1-6 alkyl, (g) C 1-6 alkoxy, (h) amino, (i) C 1-6 alkylamino, (j) di-C 1-6 alkylamino (k) C 3-6 cycloalkylamino, (l) phenyl-C 1-3 alkyl (m) phenyl, wherein said phenyl is optionally substituted with one to three groups independently selected in each occurrence from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, halogen, —SO 2 NR 6a R 6b and —NHSO 2 C 1-6 alkyl, (n) tetrahydropyranyl, (o) tetrahydrofuranyl, (p) cycloalkoxy optionally independently substituted with one or two halogen, hydroxy or oxo, (q) C 4-6 cycloalkyl-amino, (r) tetrahydropyranyl-methyl, (s) pyridinyl or (t) cyanomethyl; R 6a and R 6b are independently hydrogen, C 1-6 alkyl or C 1-6 acyl; R 7 is hydrogen or C 1-3 alkyl; R 9a and R 10a (i) taken independently, one of R 9a and R 10a is hydrogen or C 1-6 alkyl and the other of R 9a and R 10a is selected from the group consisting of hydrogen, C 1-6 alkyl and —C(═O)R 7 ; (ii) taken together with the nitrogen atom to which they are attached form an azetidine, pyrrolidine, piperidine or azepine ring said azetidine, pyrrolidine, piperidine or azepine ring optionally substituted with hydroxy, amino, C 1-3 alkylamine or C 1-3 dialkylamine; or, (iii) taken together are (CH 2 ) 2 —X—(CH 2 ) 2 ; R 9b is defined as R 9a and R 10b is defined as R 10a ; R 11 is hydrogen, C 1-6 alkyl or C 1-6 acyl; X is O, S(O) p or NR 11 wherein p is an integer from 0 to 2; Ar is phenyl optionally substituted with one to three substituents independently selected in each occurrence from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkoxy, cyano and nitro; or, pharmaceutically acceptable salts thereof.