Patent ID: 7524853

Claim:
A method of treating or inhibiting a steroid hormone dependent disease or disorder selected from the group consisting of breast cancer, prostate carcinoma, ovarian cancer, uterine cancer, endometrial cancer, endometrial hyperplasia, endometriosis, uterine fibroids, uterine leiomyoma, adenomyosis, dysmenorrhea, menorrhagia, metrorrhagia, prostadyna, benign prostatic hyperplasia, prostatitis, acne, seborrhoea, hirsutism, androgenic alopecia, precocious puberty, adrenal hyperplasia, polycystic ovarian syndrome and osteoporosis, said method comprising administering to a patient in need thereof an effective amount of a compound corresponding to formula (I) wherein X is S, SO or SO 2 R1 and R2 are individually selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloheteroalkyl, substituted cycloheteroalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, cycloheteroalkyl-alkyl, substituted cycloheteroalkyl-alkyl, whereby the cycloheteroalkyl moiety of cycloheteroalkyl-alkyl and substituted cycloheteroalkyl-alkyl is a four- to eight-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the number of N atoms being 0-3 and the number of O and S atoms each being 0-1, which ring may be saturated, partly unsaturated or hydroaromatic; whereby the cycloheteroalkyl moiety is optionally substituted by up to three substituents independently selected from the group consisting of oxo, alkyl, aryl or aryl-(C 1 -C 4 )-alkyl both optionally substituted in the aryl moiety, hydroxyl, (C 1 -C 6 )alkoxy, halogenated (C 1 -C 6 )alkyl, halogenated (C 1 -C 6 )alkoxy, carboxyl-(C 1 -C 6 )alkyl, thiol, nitrile, sulfamoyl, sulphonamide, carboxyl, aryloxy or arylalkyloxy both optionally substituted in the aryl moiety, (C 1 -C 6 )alkylthio, arylthio or arylalkyloxy both optionally substituted in the aryl moiety, (C 1 -C 6 )alkylthio, arylthio or arylalkylthio both optionally substituted in the aryl moiety, amino, amido, acyl, and acylamino; or R2 itself may be independently selected from acyl, carboxyl, or amido, wherein R1 and R2 cannot be simultaneously unsubstituted alkyl, the hydrocarbon chain —C(R3)-C(R4)-C(R5)-C(R6)- of the six-membered ring is saturated or contains one or two double bonds between the carbon atoms; R3 and R4 are individually selected from the group consisting of hydrogen, oxo, halogen or dihalogen, acyl, alkyl, substituted alkyl, hydroxyl, carboxyl, amido, amino, nitrile, thio, alkoxy, acyloxy, aryloxy, alkylthio and arylthio; R5 and R6 are individually selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, hydroxyl, alkoxy, aryloxy, acyl or carboxyl, or a pharmaceutically acceptable salt thereof.