Patent ID: 7265132

Claim:
A compound of formula (I): wherein: Het is piperidinyl optionally substituted with one or more R 5 ; Y is O or S; R 1 is C1-5 alkyl, C1-5 alkoxy, aryloxy, C3-7 cycloalkyl, phenyl, benzyl, naphthyl, tetrahydronaphthyl, C1-5alkylsulfonylC1-5alkyl, C3-7 cycloalkylsulfonylC1-5alkyl, arylsulfonylC1-5alkyl or amino; wherein R 1 is optionally substituted by one or more R a ; R a is C1-5 allyl, C3-7 cycloalkyl, phenyl or naphthyl, R a may be further optionally substituted by one or more R b ; R b is C1-5 alkyl, C3-6 cycloalkyl, aryl, C1-5 alkoxy, aryloxy, benzyloxy, halogen, hydroxy, oxo, carboxy, cyano, nitro, amidino or guanidino; R 2 is hydrogen or C1-3 alkyl; R 3 is hydrogen, C1-5 alkyl, C2-5alkylene, C3-7 cycloalkyl, arylC1-3alkyl or aryl wherein R3 is optionally substituted by one or more R c ; R c is C1-5 alkyl, C3-7 cycloalkyl, aryl, aroyl, C1-5 alkoxycarbonyl, aryloxycarbonyl, C1-5 alkanoyloxy, aroyloxy or carbamoyl wherein the nitrogen atom may be independently mono or di-substituted by C1-5 alkyl R c may be further optionally substituted by one or more R d ; R d is C1-5 alkyl, C3-6 cycloalkyl, aryl, arylalkyl, C1-5 alkoxy, aryloxy, arylC1-5alkoxy, aroyl, amino, halogen, hydroxy, oxo, carboxy, cyano, nitro, amidino or guanidino; R 4 is hydrogen or C1-3 alkyl; R 5 is C1-5 alkyl chain optionally interrupted by one or two O or S, phenyl, naphthyl, arylC1-3alkyl, C1-5 alkanoyl, aroyl, C1-5 alkoxycarbonyl, aryloxycarbonyl, benzyloxycarbonyl, carbamoyl wherein the nitrogen atom may be independantly mono or disubstituted by C1-5 alkyl, X is O or S and pharmaceutically acceptable salts, esters, tautomers, individual isomers and mixtures of isomers thereof.