Patent ID: 8835648

Claim:
Compounds of formula I and pharmaceutically acceptable salts thereof wherein, as valence permits, i is 1 or 2 R 1 is H; linear (C 1 -C 4 ) alkyl group, branched or cyclic (C 3 -C 4 ) alkyl group R 2 is H, Cl or F X is either N or CR 3 R 3 is H; halogen; a linear (C 1 -C 4 ) alkyl or alkoxy group, branched or cyclic (C 3 -C 4 ) alkyl or alkoxy group, Y is Z is O or NRx Rx is H or a linear (C 1 -C 4 ) alkyl group, branched or cyclic (C 3 -C 4 ) alkyl group k is 1, 2, 3 or 4 n and p are independently 1, 2 or 3 and the sum n+p cannot exceed 5 T is H or a linear (C 1 -C 4 ) alkyl group or branched (C 3 -C 4 ) alkyl group; T′ is a linear (C 1 -C 3 ) alkyl chain or branched C 3 alkyl chain substituted with either a (C 1 -C 6 )-dialkylamino group or a 4 to 6 membered saturated heterocycle containing one nitrogen atom and optionally containing a second heteroatom selected from N and O, such heterocyclic ring being optionally substituted a the nitrogen atoms with a (C 1 -C 4 ) alkyl chain; or a 4 to 6 membered saturated heterocycle containing one nitrogen atom and optionally containing a second heteroatom selected from N and O, such heterocyclic ring being optionally substituted at the nitrogen atoms with a (C 1 -C 4 ) alkyl chain r is zero, 1, 2 or 3; R′ is halogen; hydroxy; amino; cyano; nitro; oxo; linear (C 1 -C 6 ) alkyl, or branched (C 3 -C 6 ) alkyl, dihaloalkyl, azaalkyl, oxaalkyl, alkylcarbonyl, oxaalkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonylamino, alkenyl, oxaalkenyl, azaalkenyl, alkenylcarbonyl, oxaalkenylcarbonyl, alkenyloxycarbonyl, alkenylaminocarbonyl, alkylamino, dialkylamino, mercaptoalkyl, alkoxy, or alkylthio group optionally substituted with one or more fluorine atoms; or wherein two R′ groups may form a 5- to 8-membered ring with spiro or fused junction; with the exclusion of: