Patent ID: 8309572

Claim:
A method of inhibiting the binding of acetylcholine to an acetylcholine receptor in a human in need thereof, which comprises contacting the acetylcholine receptor with an effective amount of a compound of Formula (I) wherein R1 is R2 and R3 are independently selected from the group consisting of F, G, H, K and L are independently selected from the group consisting of hydrogen, halogen, C 1-4 alkyl, halosubstituted C 1-4 alkyl, hydroxy substituted alkyl, and C 1-4 alkoxy; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-4 alkyl, aryl, —C1-4 alkyl aryl, cyano, nitro, —(CR7R7)pORb and (CR7R7)pNRbRb; R6 is selected from the group consisting of hydrogen, C1-4 alkyl; m is an integer having a value of 1 to 15; t is 0 or an integer having a value of 1 to 5; p is 0 or an integer having a value of 1 to 4; Rb is selected from the group consisting of hydrogen, —C1-4 alkyl, aryl and —C1-4 alkyl aryl; R7 is selected from the group consisting of hydrogen, C1-4 alkyl, halosubstituted C1-4 alkyl, and hydroxy substituted C1-4 alkyl; and X − is a pharmaceutically acceptable anion, and wherein the method of contacting the receptor is by topical application to said human.