Patent ID: 6916843

Claim:
A method for reducing cell death from hypoxia-reoxygenation, comprising: contacting a cell undergoing hypoxia reoxygenation with an effective amount of a composition of matter selected from the group consisting of epoxyeicosatrienoic acids (EETs), epoxyeicosatrienoic acid metabolic products, epoxyeicosatrienoic acid analogs, dihydroxycicosatrienoic acid analogs, and combinations thereof, wherein the epoxyeicosatrienoic acid analogs and dihydroxyeicosatrienoic acid analogs comprise an episulfide derivative; a sulfonamide derivative; and analog in which one or more EET olefins are removed; an analog in which an EET olefin is replaced with an acetylene group of a cyclopropane group; an analog in which an eopxide moiety is replaced with an oxitane or furane ring, wherein the composition reduces cell death in the cell undergoing hypoxia-reoxygenation.