Patent ID: 7772220

Claim:
A method of ameliorating or eliminating a p53-mediated toxic effect of a pharmaceutical compound in a subject comprising: administering to a subject a clear aqueous solution comprising: (a) a first material selected from the group consisting of a bile acid, a bile acid salt, and a bile acid conjugated with an amine by an amide linkage; (b) a carbohydrate selected from the group consisting of an aqueous soluble starch conversion product or an aqueous soluble non-starch polysaccharide; (c) water, wherein the first material and the carbohydrate both remain in solution for all pH values attainable in an aqueous solution; and administering a pharmaceutical compound that has a toxic effect in the subject, wherein the pharmaceutical compound is selected from the group consisting of cisplatin, carboplatin, oxaliplatin, suramin, bleomycin sulfate, mitomycin, epothitone, sulfasalazine, disulfiram, vincristine, vidarabine, leflunomide, and bortezomib.