Patent ID: 8383146

Claim:
A process for the preparation of a particulate composition intended for the oral administration of a particulate active ingredient with unacceptable taste, comprising: mixing the particulate active ingredient in a molten ester of glycerol, wherein the ester of glycerol is present in an amount of between about 50% and about 85% by weight of the total composition; adding a lecithin as a surfactant in an amount of between about 1% and about 3% by weight of the total composition; optionally adding one or more excipients; and spray-cooling the resulting molten mixture using a device equipped with a two-fluid nozzle at the top of a tower into which a cold gaseous counter-current is introduced; wherein the final particulate composition comprises more than 90% of the particles having a particle size of less than about 350 μm, and the dissolution rate of 80 to 100% in 60 min at pH 1.