Patent ID: 8063099

Claim:
A compound of formula (I), wherein the stereogenic centers are in a (1S,2S,5R)-configuration wherein A represents aryl or heterocyclyl, wherein the aryl or heterocyclyl is unsubstituted or independently mono- or di-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 3-6 )cycloalkyl, (C 1-4 )alkoxy, trifluoromethyl, —NR 2 R 3 and halogen; B represents a hydrogen atom or an aryl- or heterocyclyl-group, wherein the aryl or heterocyclyl is unsubstituted or independently mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 3-6 )cycloalkyl, (C 1-4 )alkoxy, trifluoromethyl, cyano, —NR 2 R 3 , —NHSO 2 —(C 1-4 )alkyl, —N(R 2 )C(O)R 3 and halogen; n represents the integer 1; R 1 represents aryl or heterocyclyl, wherein the aryl or heterocyclyl is unsubstituted or independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 3-6 )cycloalkyl, (C 1-4 )alkoxy, halogen, cyano, trifluoromethyl, trifluoromethoxy and —NR 2 R 3 ; or R 1 represents a phenyl group which group is mono-substituted with a group selected from morpholin-4-yl and 4-methyl-piperazinyl; or R 1 represents a 2,3-dihydro-benzofuranyl-, a 2,3-dihydro-benzo[1,4]dioxinyl-, a 4H-benzo[1,3]dioxinyl-, a 2,3-dihydro-thieno[3,4-b][1,4]dioxinyl-, a 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazinyl-, a 2H-chromenyl-, a 3,4-dihydro-2H-benzo[1,4]oxazinyl- or a chromanyl-group which groups are unsubstituted or independently mono- or di-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy and halogen; R 2 represents hydrogen or (C 1-4 )alkyl; and R 3 represents hydrogen or (C 1-4 )alkyl; or a pharmaceutically acceptable salt thereof.