Patent ID: 7282500

Claim:
A compound of formula (I): wherein: X is O, CH 2 , S or NH, or the moiety X-R 1 is hydrogen; Y 1 and Y 2 independently represent CH; R 1 _is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, arylC 1-6 alkyl, any of which except hydrogen is unsubstituted or substituted with substituent or substituents as defined below; R 2 and R 3 independently represent hydrogen, heterocyclyl, or heterocyclylC 1-6 alkyl-, wherein the heterocycl or heterocyclylC 1-6 alkyl is morpholine; Ar is a group of the formula a) or b): wherein A represents a fused 5 membered ring; R a and R 4 are independently selected from hydrogen, halogen, C 1-6 alkyl, aryl, arylC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, haloC 1-6 alkyl, arylC 1-6 alkoxy, hydroxy, nitro, cyano, azido, amino, mono- and di-N—C 1-6 alkylamino, acylamino, arylcarbonylamino, acyloxy, carboxy, carbamoyl, mono- and di-N—C 1-6 alkylcarbamoyl, C 1-6 alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkylamidino, sulphonylamino, aminosulphonyl, C 1-6 alkylthio, C 1-6 alkyl sulphinyl or C 1-6 alkylsulphonyl; and one of X 1 and X 2 is N and the other is NR 6 , wherein R 6 is hydrogen, C 1-6 alkyl, or arylC 1-6 alkyl; or a pharmaceutically acceptable salt thereof wherein the substituent or substituents for C 1-6 alkyl or C 1-6 cycloalkyl of R 1 as defined above is or are selected from: aryl, C 1-6 alkoxy, C 1-6 alkylthio, arylC 1-6 alkoxy, aryl C 1-6 alkylthio, amino, mono- or di-C 1-6 alkylamino, aminosulphonyl, cycloalkyl, cycloalkenyl, COOH, amide, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkylamidino, hydroxy, and halogen or a combination thereof; and wherein the substituent or substituents for an aryl, arylC 1-6 alkyl, of R 1 as defined above is or are selected from: halogen, C 1-6 alkyl, aryl, aryl C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy C 1-6 alkyl, haloC 1-6 alkyl, aryl C 1-6 alkoxy, hydroxy, nitro, cyano, azido, amino, mono- and di-N—C 1-6 alkylamino, acylamino, arylcarbonylamino, COOH, carbamoyl, mono- and di-N—C 1-6 alkylcarbamoyl, C 1-6 alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkyl amidino, sulphonylamino, aminosulphonyl, C 1-6 alkylthio, C 1-6 alkylsulphinyl, C 1-6 alkylsulphonyl, or hydroxyimino-C 1-6 alkyl or a combination thereof.