Patent ID: 8623899

Claim:
A compound of Formula I including any possible stereoisomers thereof, wherein: R and R′ are independently selected from —CR 1 R 2 R 3 , aryl optionally substituted with 1 or 2 substituents selected from halo and methyl, and heteroC 4-7 cycloalkyl, wherein R 1 is selected from C 1-4 alkyl optionally substituted with methoxy, hydroxyl or dimethylamino; C 3-6 cycloalkyl; phenyl optionally substituted with 1, 2 or 3 substituents independently selected from halo, C 1-4 alkoxy, trifluoromethoxy or 2 substituents on adjacent ring atoms form a 1,3-dioxolane group; benzyl optionally substituted with halo or methoxy; heteroaryl; and heteroarylmethyl; R 2 is selected from hydrogen, hydroxyl, amino, mono- and di-C 1-4 alkylamino, (C 3-6 cycloalkyl)(C 1-4 alkyl)amino, C 1-4 alkylcarbonylamino, phenylamino, C 1-4 alkyloxycarbonylamino, (C 1-4 alkyloxycarbonyl)(C 1-4 alkyl)amino, C 1-4 alkylaminocarbonylamino, tetrahydro-2-oxo-1(2H)-pyrimidinyl, pyrrolidin-1-yl, piperidin-1-yl, 3,3-difluoropiperidin-1-yl, morpholin-1-yl, 7-aza-bicyclo[2.2.1]hept-7-yl, and imidazol-1-yl; and R 3 is hydrogen or C 1-4 alkyl, or CR 2 R 3 together forms carbonyl; or CR 1 R 3 forms a cyclopropyl group; and the pharmaceutically acceptable salts thereof; provided that (a) when R and R′ are identical and represent —CR 1 R 2 R 3 wherein (a-1) R 2 is C 1-4 alkyloxycarbonylamino and R 3 is hydrogen, then R 1 is other than unsubstituted C 1-4 alkyl, or ethyl substituted with hydroxyl or methoxy; or wherein (a-2) R 2 is methyloxycarbonylamino and R 3 is hydrogen, then R 1 is other than unsubstituted phenyl; and (b) when R and R′ are different and each independently represent —CR 1 R 2 R 3 , wherein R 1 is phenyl or 2-propyl, R 2 is dimethylamine and R 3 is hydrogen in one —CR 1 R 2 R 3 group, then the other —CR 1 R 2 R 3 group cannot take the meaning of R 1 being 2-propyl and R 2 being methyloxycarbonylamino and R 3 being hydrogen.