Patent ID: 8658194

Claim:
A medical article, comprising an implantable substrate and a polymer coating disposed at least on a portion of the substrate, the coating comprises a primer layer and a reservoir layer, wherein the reservoir layer includes a segmented polyurethane comprising a soft segment and a hard segment; wherein the soft segment is derived from a polyol and the hard segment is derived from an isocyanate, wherein the polymer coating further includes a hydrophilic therapeutic agent selected from the group consisting of cyclic-RGD peptide, poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(L-lysine), poly(D-lysine), poly(δ-guanidino-α-aminobutyric acid), a racemic mixture of poly(L-arginine) with poly(D-arginine), elastin mimetic polypeptides, and combinations thereof, wherein the hydrophilic therapeutic agent and the segmented polyurethane has a mass ratio that is between about 1:10 and about 1:3; wherein the primer layer comprises an acrylic polymer.