Patent ID: 7449492

Claim:
A method for effecting the recognition in a host of a latent virus infection, which method comprises administering to said host an amount of a chemical agent effective to activate said virus to cause the virus to replicate itself and, become visible to the host, said chemical agent being an isolated ingenane, or pharmaceutically acceptable salt thereof, said ingenane having the formula: wherein: R 24 , R 25 and R 26 are independently selected from hydrogen, R 27 , R 28 , F, Cl, Br, I, OH, CN, OR 27 , SR 27 , NR 27 R 28 , N(═O) 2 , NR 27 OR 28 , ONR 27 R 28 , SOR 27 , SO 2 R 27 , SO 3 R 27 , SONR 27 R 28 , SO 2 NR 27 R 28 , SO 3 NR 27 R 28 , P(R 27 ) 3 , P(═O)(R 27 ) 3 , Si(R 27 ) 3 , B(R 27 ) 2 , (C═X)R 29 or X(C═X)R 29 where X is selected from sulfur, oxygen and nitrogen; R 27 and R 28 are each independently selected from C 1 -C 20 alkyl (branched and/or straight chained), aryl C 1 -C 20 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 14 aryl, C 1 -C 14 heteroaryl, C 1 -C 14 heterocycle, C 2 -C 10 alkenyl (branched and/or straight chained), C 2 -C 10 alkynyl (branched and/or straight chained), C 1 -C 10 heteroarylalkyl, C 1 -C 10 alkoxyalkyl, C 1 -C 10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C 1 -C 10 alkyl which is unsubstituted or substituted by CN, OR 30 , SR 30 , NR 30 R 31 , N═(O) 2 , NR 30 OR 31 , ONR 30 R 31 , SOR 30 , SO 2 R 30 SO 3 R 30 , SONR 30 R 31 , SO 2 NR 30 R 31 , SO 3 NR 30 R 31 , P(R 30 ) 3 , P═(O)(R 30 ) 3 , Si(R 30 ) 3 , and B(R 30 ) 2 ; R 29 is selected from R 27 , R 28 , CN, COR 27 , CO 2 R 27 , OR 27 , SR 27 , NR 27 R 28 , N(═O) 2 , NR 27 OR 28 , ONR 27 R 28 , SOR 27 , SO 2 R 27 , SO 3 R 27 , SONR 27 R 28 , SO 2 NR 27 R 28 , SO 3 NR 27 R 28 , P(R 27 ) 3 , P(═O)(R 27 ) 3 , Si(R 27 ) 3 , and B(R 27 ) 2 SO 3 NR 27 R 28 , P(R 27 ) 3 , P(═O)(R 27 ) 3 , Si(R 27 ) 3 , and B(R 27 ) 2 ; and each R 30 and R 31 are independently C 1 -C 20 alkyl, aryl C 1 -C 20 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 14 aryl, C 1 -C 14 heteroaryl, C 1 -C 14 -heterocycle, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 1 -C 10 heteroarylalkyl, C 1 -C 10 alkoxyalkyl, C 1 -C 10 haloalkyl, dihaloalkyl, trihaloalkyl, and haloalkoxy.