Patent ID: 7217794

Claim:
A purified human Factor XI protein comprising amino acids 370–607 as set forth in SEQ ID NO: 15 and one of the following mutations at a position relative to the sequence set forth in SEQ ID NO: 15: (i) S434A; (ii) T475A; (iii) S434A, T475A; (iv) S434A, T475A, K422A (v) S434A, T475A, K437A; (vi) S434A, T475A, K486A; (vii) S434A, T475A, K505A; (viii) S434A, T475A, K509A; (ix) S434A, T475A, C482S; (x) S434A, T475A, C482S, K437A; (xi) S434A, T475A, C482S, R479A; (xii) S434A, T475A, C482S, K505A; (xiii) S434A, T475A, C482S, D476A; (xiv) S434A, T475A, C-terminal truncation of A606 and V607; or (xv) S434A, T475A, C482S, Y416S.