Patent ID: 7037897

Claim:
A compound of formula (I) Xaa 1 -Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Xaa 6 (SEQ ID NO: 1) (I), or a therapeutically acceptable salt thereof, wherein Xaa 1 is R—(CH 2 ) n —C(O)—, wherein n is an integer from 0 to 8 and R is selected from the group consisting of alkoxy, alkyl, amino, aryl, carboxyl, cycloalkenyl, cycloalkyl, and heterocycle; Xaa 2 is selected from the group consisting of N-methylalanyl, allothreonyl, allylglycyl, arginyl, beta-alanyl, glutaminyl, D-glutaminyl, glycyl, homoseryl, leucyl, lysyl(N-epsilon acetyl), norleucyl, norvalyl, D-norvalyl, N-methylnorvalyl, omithyl(N-delta acetyl), 3-(3-pyridyl)alanyl, sarcosyl, seryl, D-seryl, N-methylseryl, threonyl, tryptyl, D-tryptyl, valyl, and N-methylvalyl; Xaa 3 is selected from the group consisting of alanyl, alloisoleucyl, aspartyl, citrullyl, isoleucyl, D-isoleucyl, N-methylisoleucyl, leucyl, D-leucyl, lysyl(N-epsilon acetyl), D-lysyl(N-epsilon acetyl), norvalyl, phenylalanyl, prolyl, and D-prolyl; Xaa 4 is selected from the group consisting of arginyl, D-arginyl, citrullyl, histidyl, isoleucyl, lysyl, lysyl(N-epsilon isopropyl), ornithyl, and 3-(3-pyridyl)alanyl; Xaa 5 is absent or selected from the group consisting of N-methyl-D-alanyl, 2-aminobutyryl, 2-aminoisobutyryl, arginyl, D-glutaminyl, homoprolyl, hydroxyprolyl, leucyl, phenylalanyl, prolyl, D-prolyl, and D-valyl; provided that when Xaa 4 is arginyl or D-arginyl then Xaa 5 is other than arginyl; and Xaa 6 is selected from the group consisting of hydroxyl, D-alanylamide, azaglycylamide, glycylamide, D-lysyl(N-epsilon acetyl)amide, prolylethylamide, —NHCH(CH 3 ) 2 , a group represented by the formula —NH—(CH 2 ) n —CHR 1 R 2 , and a group represented by the formula —NHR 3 , wherein n is an integer from 0 to 8; R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkenyl, and cycloalkyl; R 2 is selected from the group consisting of hydrogen, alkoxy, alkyl, aryl, cycloalkenyl, cycloalkyl, heterocycle, and hydroxyl, with the proviso that when n is 0, R 2 is other than alkoxy or hydroxyl; and R 3 is selected from the group consisting of hydrogen, cycloalkenyl, cycloalkyl, and hydroxyl.