Patent ID: 7179907

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: wherein X is CH 2 , NH, or O; R 1 , is selected from the group consisting of C 1 –C 20 alkyl, C 2 –C 20 akenyl, C 2 –C 20 alkynyl, OR 6 , C(O)R 6 , carboalkoxyalkyl, a heterocyclyl selected from the group consisting of furanyl, pyridyl, pyrrolyl and imidazolyl, aromatic hydrocarbon and cycloalkyl, all of which may be optionally substituted by one or more of the groups selected from C 1 –C 20 alkyl, C 2 –C 20 alkenyl, C 2 –C 20 alkynyl, cycloalkyl, a heterocyclyl selected from the group consisting of furanyl, pyridyl, pyrrolyl and imidazolyl, aryl, halogen, cyano, nitro, amino, alkylamino, dialkylamino, aminoalkyl, dialkylaminoalkyl, arylamino, aminoaryl, alkylaminoaryl, alkylcarbonylamino, carboxy, carboxyalkyl, C(O)R 6 , OR 6 , CONR 6, wherein all said substituents may be optionally substituted with one or more selected from the group consisting of halogen, C 1 –C 20 alkyl, C 2 –C 20 alkenyl, C 2 –C 20 alkynyl, cycloalkyl, OR 6 , C(O)R 6 , carboalkoxyalkyl, cyano, and nitro; R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of hydrogen, C 1 –C 20 alkyl, C 2 –C 20 akenyl, C 2 –C 20 alkynyl, OR 6 , C(O)R 6 , carboalkoxyalkyl, a heterocyclyl selected from the group consisting of furanyl, pyridyl, pyrrolyl and imidazolyl, aromatic hydrocarbon and cycloalkyl, all of which may be optionally substituted by one or more of the groups selected from C 1 –C 20 alkyl, C 2 –C 20 alkenyl, C 2 –C 20 alkynyl, cycloalkyl, a heterocyclyl selected from the group consisting of furanyl, pyridyl, pyrrolyl and imidazolyl, aryl, halogen, cyano, nitro, amino, alkylamino, dialkylamino, aminoalkyl, dialkylaminoalkyl, arylamino, aminoaryl, alkylaminoaryl, alkylcarbonylamino, carboxy, carboxyalkyl, C(O)R 6 , OR 6 , CONR 6, wherein all said substituents may be optionally substituted with one or more selected from the group consisting of halogen, C 1 –C 20 alkyl, C 2 –C 20 alkenyl, C 2 –C 20 alkynyl, cycloalkyl, OR 6 , C(O)R 6 , carboalkoxyalkyl, cyano, and nitro; and R 6 is selected from the group consisting of hydrogen, halogen, C 1 –C 20 alkyl, aromatic hydrocarbon, and alkylaryl, wherein all said substituents may be optionally substituted by one or more carboalkoxy, amino, hydroxyl, carboxyl, lower alkyl, lower alkenyl, lower alkynyl, halo, cyano, nitro, carboxyalkyl, and unsubstituted carbamoyl.