Patent ID: 7652061

Claim:
A compound of the formula wherein L is a radical of the formula: in which R 1 is hydrogen, optionally substituted alkyl, aryl, heteroaryl, aralkyl or cycloalkyl; R 2 is hydrogen, hydroxy, oxo, optionally substituted alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, alkylthio, arylthio or aralkylthio; R 3 is hydrogen; or R 2 and R 3 combined are alkylene which together with the carbon atoms to which they are attached form a fused 5- to 7-membered ring; or R 2 and R 3 combined are a bond between the carbon atoms to which they are attached; n is zero or an integer of 1 or 2; Y a is hydrogen; or Y a and R 2 combined are a bond between the carbon atoms to which they are attached; R 4a is hydrogen; or R 4a and Y a combined are a bond between the carbon atoms to which they are attached; R and R′ are independently hydrogen, halogen, optionally substituted alkyl, alkoxy, aralkyl or heteroaralkyl; or R and R′ combined together with the carbon atoms to which they are attached form an optionally substituted fused 5- to 6-membered aromatic or heteroaromatic ring provided that R and R′ are attached to carbon atoms adjacent to each other; or R—C and R′—C may independently be replaced by nitrogen; X 1 is -Z-(CH 2 ) p -Q-W wherein Z is a bond, O, S, S(O) or S(O) 2 ; or Z is —C(O)NR 5 — in which R 5 is hydrogen, alkyl or aralkyl; p is an integer from 1 to 8; Q is a bond; or Q is —O(CH 2 ) r — or —S(CH 2 ) r — in which r is zero or an integer from 1 to 8; or Q is —O(CH 2 ) 1-8 O—, —S(CH 2 ) 1-8 O—, —S(CH 2 ) 1-8 S— or —C(O)—; or Q is —C(O)NR 6 — in which R 6 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl; or Q is —NR 7 —, —NR 7 C(O)—, —NR 7 C(O)NR 8 — or —NR 7 C(O)O— in which R 7 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl; R 8 is hydrogen, alkyl or aralkyl; W is oxazole; X 2 is —C(R 9 ) 2 —, O, S or —NR 10 — in which R 9 is hydrogen or lower alkyl; R 10 is hydrogen, alkyl or aralkyl; or an optical isomer thereof; or a mixture of optical isomers thereof; or a pharmaceutically acceptable salt thereof.