Patent ID: 7449183

Claim:
A method for endothelializing a vascular medical device adapted for implantation into a patient, the vascular medical device containing an exposed antigenic collagen, said method comprising the steps of: (a) administering to the patient an effective amount of a bispecific antibody, said bispecific antibody comprising a first antigen binding site and a second antigen binding site, said first antigen binding site being directed against a surface marker of an endothelial progenitor cell, said surface marker being CD34, said second antigen binding site being directed against the collagen of the vascular medical device; and (b) implanting said vascular medical device in the patient, whereby the binding of said bispecific antibody to the collagen of the vascular medical device and to the CD34 on endothelial progenitor cell resulting in endothelialization of the vascular medical device.