Patent ID: 7132392

Claim:
A method of inhibiting cell motility in a mammal comprising administering to said mammal a peptide of formula (I) having cell signal inhibiting activity and cell motility inhibiting activity, wherein said peptide is substantially free of cytotoxicity; wherein n is 1–6; PTI is a phenylalanyl radical having a phenyl ring, an amine end, and a carboxyl end, the phenyl ring having one or more substituents selected from the group consisting of hydroxyl, carboxyl, formyl, carboxyalkyl, carboxyalkyloxy, dicarboxyalkyl, dicarboxyalkyloxy, dicarboxyhaloalkyl, dicarboxyhaloalkyloxy, phosphonoalkyl, and phosphonohaloalkyl, wherein the alkyl portion of the substituents may be unsubstituted or substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; X is a moiety attached to the nitrogen of PTI and is selected from the group consisting of alkylcarbonyl, oxalyl, alkylaminooxalyl, arylaminooxalyl, arylalkylaminooxalyl, alkoxyoxalyl, carboxyalkyl carbonyl, heterocyclyl carbonyl, heterocyclylalkyl carbonyl, arylalkyl heterocyclylalkyl carbonyl, aryloxycarbonyl, and arylalkoxycarbonyl, wherein the aryl and alkyl portions of the substituents may be unsubstituted or substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; and the heterocyclyl portion of X contains at least 4 hetero atoms selected from the group consisting of O, N, and S; AA is an amino acid, the amine end of which is attached to the carboxyl end of PTI; and Y is an arylalkylamino or arylheterocyclyl alkylamino, which may be unsubstituted or substituted; or a salt thereof, with provisos that when X is acetyl, n=2, the AA attached to the carboxyl end of PTI is aminocyclohexane carboxylic acid, and Y is hydroxynaphthylpropylamino, the substituent on the phenyl ring of PTI is not phosphonomethyl and when X is oxalyl, n=2, the AA attached to the carboxyl end of PTI is aminocyclohexane carboxylic acid, and Y is naphthylpropylamino, the substituent on the phenyl ring of PTI is not dicarboxymethoxy.