Patent ID: 6872861

Claim:
A process for preparing polyfluoroalkyllithium compounds comprising deprotonating polyfluoroalkyl compounds of the formula (I) HCF 2 R 1 (I) wherein R 1 is fluorine, (CF 2 ) n CF 3 , (CF 2 ) n R 2 , n is an Integer from 0 to 17, and R 2 is tri(C 1 -C 6 -alkyl)silyl, triphenylsilyl, cyclic alkyl having from 3 to 8 carbon atoms, straight-chain or branched alkyl having from 1 to 24 carbon atoms, aryl having from 6 to 10 carbon atoms, arylalkyl having from 7 to 18 carbon atoms, straight-chain or branched alkenyl having from 2 to 12 carbon atoms, straight-chain or branched alkoxy having from 1 to 12 carbon atoms, aryloxy having from 6 to 10 carbon atoms, heteroaryl having from 4 to 9 carbon atoms, heteroarylalkyl having from 5 to 17 carbon atoms, heteroaryloxy having from 4 to 9 carbon atoms, where (i) the heteroaryl radicals each contain up to 2 hetero atoms selected from the group consisting of oxygen, sulfur, and nitrogen, (ii) the alkyl radicals are optionally substituted further by fluorine, di(C 1 -C 6 -alkyl)amino, or alkylthio or alkyloxy each having from 1 to 12 carbon atoms, and (iii) the aromatic substituents optionally bear 1, 2, or 3 further substituents selected independently from the group consisting of fluorine, cyclic alkyl having from 3 to 6 carbon atoms, straight-chain or branched alkyl having from 1 to 12 carbon atoms, straight-chain or branched alkoxy or alkylthio each having from 1 to 12 carbon atoms, straight-chain or branched alkenyl having from 2 to 12 carbon atoms, di(C 1 -C 6 -alkyl)amino, or N—(C 5 -C 12 )-azacycloalkyl; wherein the deprotonation is carried out with a lithium base.