Patent ID: 8293803

Claim:
A method of using a retinoid compound to control cell differentiation, said method comprising contacting said cell with an amount of said compound sufficient to control said cell differentiation, wherein the compound is of the formula (V), wherein R 1 , R 4 and R 5 are each independently selected from hydrogen, R 6 , hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 6 , and —(CH 2 )k-heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 6 ; each R 6 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo, ═NR 7 , —OR 7 , —C(O)R 7 , —C(O)OR 7 , —OC(O)R 7 , —S(O) l R 7 , —N(R 7 )R 8 , —C(O)N(R 7 )R 8 , —S(O) l N(R 7 )R 8 and R 9 ; R 7 and R 8 are each independently hydrogen or R 9 ; R 9 is selected from hydrocarbyl and —(CH 2 ) k -heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C 1-6 alkyl and C 1-6 alkoxy; k is 0, 1, 2, 3, 4, 5 or 6; l is 0, 1 or 2; R 11 , R 12 , R 14 and R 15 are each independently selected from hydrogen, R 6 , hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 6 , and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 6 ; and Z is selected from —OH and NHOH; and wherein any one or more of the aliphatic and the aromatic groups of formula V may optionally be substituted with one or more R 6 groups; or a salt thereof.