Patent ID: 7230007

Claim:
A compound of formula I wherein X 1 is N; X 2 , X 3 and X 4 are; CR 2 ; R 2 is H, F, Cl, Br, I, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms, polyfluoroalkyl having 1, 2, 3 or 4 carbon atoms, SO 2 alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, NRaRb, hydroxyl, alkoxy having 1, 2, 3, 4, 5 or 6 carbon atoms, hydroxyalkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or dialkylaminoalkyl with each alkyl having independently 1, 2, 3, 4, 5 or 6 carbon atoms; R1 is aryl, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms, polyfluoroalkyl having 1, 2, 3 or 4 carbon atoms, arylalkyl with alkyl having 1, 2, 3 or 4 carbon atoms, heteroarylalkyl with alkyl having 1, 2, 3 or 4 carbon atoms or heteroaryl, wherein said aryl or heteroaryl is optionally substituted by one or more substituents selected from the group consisting of alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms, F, Cl, Br, I, NO 2 , NH 2 , alkylamino with alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, NRaRb, alkylcarbonylamino having 1, 2, 3, 4, 5 or 6 carbon atoms, hydroxyl, alkoxy having 1, 2, 3, 4, 5 or 6 carbon atoms, S(O) n R 3 , CO 2 H, alkoxycarbonyl having 1, 2, 3, 4, 5 or 6 carbon atoms, alkylcarbonyl having 1, 2, 3, 4, 5 or 6 carbon atoms, CONH 2 , CONRaRb, alkylsulfonylamino with alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cyano, polyfluoroalkyl having 1, 2, 3 or 4 carbon atoms, polyfluoroalkoxy having 1, 2 or 3 carbon atoms and SO 3 H; n is 0,1 or 2; Ra and Rb are, independently of one another, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, or Ra and Rb form together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which can optionally contain another heteroatom chosen from the group consisting of O, S and N; and R 3 is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, alkylamino having 1, 2, 3, 4, 5 or 6 carbon atoms or NH 2 ; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, a tautomers thereof, or a pharmaceutically acceptable salt thereof.