Patent ID: 8592177

Claim:
A process for the fermentative production of an organic chemical compound, comprising: a) producing a fermentation broth by fermenting a recombinant coryneform bacterium in a medium comprising a carbon source selected from the group consisting of: glucose, fructose, sucrose, and acetic acid, wherein said recombinant coryneform bacterium: i) secretes said organic chemical compound; ii) has the ability to utilize as a carbon source one or more of the sugars selected from the group consisting of: glucose, fructose; sucrose, and acetic acid; iii) comprises a feedback resistant aspartate kinase; and iv) comprises a SugR regulator that comprises the sequence of SEQ ID NO:2 except for one or more differences selected from the group consisting of: aa) the amino acid at position 37 is selected from the group consisting of: L-alanine, glycine, L-isoleucine and L-proline; bb) the amino acid at position 38 is selected from the group consisting of: L-alanine, glycine, L-isoleucine and L-proline; cc) the amino acid at position 39 is selected from the group consisting of: L-alanine, glycine, L-isoleucine and L-proline; dd) the amino acid at position 40 is L-proline; ee) the amino acid at position 72 is selected from the group consisting of: L-alanine, glycine, L-glutamic acid and L-aspartic acid; ff) the amino acid at position 101 is selected from the group consisting of: L-arginine, L-lysine, L-phenylalanine, L-methionine, L-glutamine, L-tryptophan, L-tyrosine and L-glutamic acid; gg) the amino acid at position 105 is selected from the group consisting of: L-proline, L-phenylalanine, L-isoleucine, L-methionine, L-glutamine, L-tryptophan and L-tyrosine; hh) the amino acid at position 210 is selected from the group consisting of: L-alanine, L-arginine, and L-proline; and ii) the amino acid at position 216 is selected from the group consisting of: L-alanine, L-glutamic acid, L-isoleucine and L-tryptophan; and b) collecting said fermentation broth containing said organic chemical compound.