Patent ID: 8047204

Claim:
A dosage form for delivery of a pharmaceutical composition, the dosage form comprising: a first dosage blister chamber containing a first component of the pharmaceutical composition; a second dosage blister chamber containing a second component of the pharmaceutical composition; and a dispensing blister chamber comprising: a piercable membrane and a piercing device comprising: a substantially hollow, elongate member with a base end and a piercing tip opposite the base end and providing a discharge nozzle; one or more inlet openings on or near the base end and an internal conduit providing fluid communication between the one or more inlet ports and the discharge nozzle; and structural features on the surface of the internal conduit to control the spray pattern and droplet size of a fluid forced through the piercing device during use; wherein the dosage form further comprises: a first delamination seal, wherein the first delamination seal prevents mixing of the contents of the first dosage blister chamber with the contents of the second dosage blister chamber; a second delamination seal, wherein the second delamination seal prevents mixing of the contents of the first dosage blister chamber and the second dosage blister chamber with the dispensing chamber; and a permanent seal, wherein the permanent seal surrounds the outer perimeter of the first dosage blister chamber, the second dosage blister chamber and the dispensing blister chamber; wherein the first and second delamination seals have less adhesion than the permanent seal, such that the first and second delamination seals delaminate under significantly less pressure than the permanent seal.