Patent ID: 7378433

Claim:
A method of treating a warm-blooded animal suffering from a keratinization disorder selected from the group consisting of rosacea, acne, and psoriasis comprising administering to the warm-blooded animal a therapeutic effective amount of a compound of formula I: an N-oxide, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein: R 1 represents hydrogen, hydroxy, C 1-6 alkyl or aryl; R 2 represents hydrogen; C 1-12 alkyl; C 3-7 cycloalkyl; C 2-8 alkenyl; aryl; pyrrolidinyl optionally substituted with C 1-4 alkyl or C 1-4 alkyloxycarbonyl; or C 1-12 alkyl substituted with one or two substituents selected from C 3-7 cycloalkyl, hydroxy, C 1-4 alkyloxy, cyano, amino, mono- and di(C 1-4 alkyl)amino, mono- and di(aryl)amino, arylC 1-4 alkylamino, (C 1-4 alkyl)(arylC 1-4 alkyl)amino, pyrrolidinyl, piperidinyl, piperazinyl optionally substituted with C 1-4 alkyl, morpholinyl, perhydro-azepinyl, carboxyl, C 1-4 alkyloxycarbonyl, aminocarbonyl, mono- and di(C 1-4 alkyl)aminocarbonyl, aryl, aryloxy and arylthio; R 3 represents hydrogen, C 1-6 alkyl, aryl or C 1-6 alkyl substituted with aryl; Het represents an unsaturated heterocycle selected from imidazolyl triazolyl, or tetrazolyl; each of said unsaturated heterocycles may optionally be substituted with amino, mercapto, C 1-6 alkyl, C 1-6 alkylthio or aryl; represents a radical of formula wherein each X independently represents S, S(═O) or S(═O) 2 ; R 4 and R 5 each independently represent hydrogen, hydroxy, halo, cyano, nitro, amino, C 1-6 alkyl, hydroxyC 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkyloxy, formyl, carboxyl, mono- or di(C 1-6 alkyl)amino, C 1-6 alkyloxycarbonyl or aryl; —R 6 —R 7 — represents a bivalent radical of formula: —CR 9 ═CR 9 —CR 9 ═CR 9 — (b-1); wherein each R 9 independently represents hydrogen, hydroxy, halo, nitro, amino, C 1-6 alkyl, hydroxyC 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkyloxy, formyl, carboxyl, mono- or di(C 1-6 alkyl)amino, C 1-6 alkyloxycarbonyl or aryl; aryl represents phenyl or phenyl substituted with one, two or three substituents selected from hydroxy, halo, cyano, amino, mono- or di(C 1-6 alkyl)amino, C 1-6 alkyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxy, formyl, carboxyl and C 1-6 alkylcarbonyl; or two adjacent carbon atoms on said phenyl may be substituted by a single bivalent radical having the formula C 1-12 alkanediyl or haloC 1-12 alkanediyl.