Patent ID: 7223798

Claim:
A compound of formula (II): wherein: each R 1 , R 2 and R 3 are independently halo, —OR 6 , —SR 6 , —S(O) t R 7 (where t is 1 or 2) or —N(R 7 )R 8 ; or R 1 and R 2 together with the carbons to which they are attached form a monocyclic heterocyclic structure selected from the following: or R 1 and R 2 together with the carbons to which they are attached form the following bicyclical heterocyclic structure: (where q is 0 to 3, p is 1 to 4 and each R 15 is hydrogen, alkyl, aralkyl or aryl); each R 4 is —R 9 —R 12 , —R 9 —R 13 —R 11 , —R 9 —O—R 10 —R 11 , —R 9 —O—R 12 , —R 9 —C(O)—R 10 —R 11 , —R 9 —N(R 7 )—R 10 —R 11 , —R 9 —S(O) t —R 10 —R 11 (where t is 0 to 2), or —R 9 —C(F) 2 —R 9 —R 11 ; each R 5 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halo, haloalkyl and haloalkoxy); each R 6 is independently hydrogen, alkyl, aryl, aralkyl, —C(O)R 7 , —C(S)R 7 , —C(O)OR 14 , —C(S)OR 14 , —C(O)N(R 7 )R 8 , or —C(S)N(R 7 )R 8 ; each R 7 is independently hydrogen, alkyl, cycloalkyl, aryl, or aralkyl; R 8 is independently hydrogen, alkyl, aryl, aralkyl, —C(O)R 7 , —C(O)OR 14 , or cycloalkyl (optionally substituted with one more substituents selected from the group consisting of alkyl, —N(R 7 ) 2 , and —C(O)OR 7 ); each R 9 is independently a direct bond or a straight or branched alkylene chain; each R 10 is independently a straight or branched alkylene chain, a straight or branched alkenylene chain, a straight or branched alkynylene chain or a cycloalkylene; each R 11 is independently —C(O)OR 7 , —C(O)N(R 7 ) 2 , —P(O)(OR 7 ) 2 , —S(O) 2 OR 7 , —S(O) 2 N(H)R 7 or tetrazole; R 12 is aryl (substituted by —C(O)OR 7 or —C(O)N(R 7 ) 2 and optionally by one or more substituents selected from the group consisting of alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (substituted by —C(O)OR 7 or —C(O)N(R 7 ) 2 and optionally by one or more substituents selected from the group consisting of alkyl, alkoxy, halo, haloalkyl and haloalkoxy); R 13 is a branched alkylene chain, a straight or branched alkenylene chain or a cycloalkylene; and R 14 is alkyl, aryl or aralkyl; as a single stereoisomer, a mixture of stereoisomers, a racemic mixture of stereoisomers; or as a cyclodextrin clathrate thereof, or as a pharmaceutically acceptable salt thereof.