Patent ID: RE39049

Claim:
A method of inhibiting post- menopausal bone loss in a postmenopausal woman in need of treatment to prevent or to treat post- menopausal osteoporosis comprising administering to a human said woman in need of said treatment an amount of a compound of Formula I wherein X is a bond, CH 2 , or CH 2 CH 2 ; R and R 1 , independently, are hydrogen, hydroxyl, C 1 -C 6 -alkoxy, C 1 -C 6 -acyloxy, C 1 -C 6 -akoxy-C 2 -C 6 -acyloxy, R 3 -substituted aryloxy, R 3 -substituted aroyloxy, R 4 -substituted carbonyloxy, chloro, or bromo; R 2 is a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, and hexamethyleneimino; R 3 is C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy, hydrogen, or halo; and R 4 is C 1 -C 6 -alkoxy or aryloxy; or a pharmaceutically acceptable salt thereof, that is effective to inhibit post- menopausal bone loss in a human said woman .