Patent ID: 7211576

Claim:
A compound of formula (I): wherein, n is 0 or 1; R 1 and R 2 are each independently selected from the group consisting of H, lower alkyl, CO 2 R 5 , SO 2 R 6 , and COR 6 ; or alternatively, R 1 and R 2 can form a ring having a total of 5–7 ring atoms, said ring comprising carbon atoms, said carbon atoms optionally being replaced by one or two heteroatoms, and said ring atoms optionally being substituted by OR 6 ; R 3 is selected from the group consisting of H, lower alkyl, O-lower alkyl, halogen, OH, CN, NO 2 , and COOH; R 4 is selected from the group consisting of H, lower alkyl, cycloalkyl, O-lower alkyl, halogen, NO 2 , S-lower alkyl, CF 3 , NR 5 R 6 , CONR 7 R 8 , CO 2 R 6 , OH, and CN; or alternatively, R 3 and R 4 , together with the two carbon atoms and bond between them from the benzene ring to which R 3 and R 4 are attached, can form a ring having 5–7 ring atoms, said 5–7 atom ring comprising carbon atoms, said carbon atoms optionally being replaced by one or two heteroatoms, and said ring atoms optionally being substituted by C 1 –C 4 alkyl and CO 2 R 6 ; R 4′ is H or halogen; R 5 and R 6 are each independently selected from the group consisting of H, lower alkyl, cycloalkyl, heterocycle, aryl, and aryl substituted by lower alkoxy, halogen, or CN; R 7 and R 8 are each independently selected from the group consisting of H, lower alkyl, lower alkyl substituted by OR 5 , and NR 5 R 6 ; or alternatively, the group NR 7 R 8 can form a ring having a total of 5–7 ring atoms, said ring atoms comprising in addition to the nitrogen to which R 7 and R 8 are bonded, carbon ring atoms, said carbon ring atoms optionally being replaced by one or two heteroatoms, and said ring atoms being optionally substituted by C 1 –C 4 alkyl, COR 6 , CONR 5 R 6 , or CO 2 R 6 ; or a pharmaceutically acceptable salt or ester thereof.