Patent ID: 8404277

Claim:
A matrix-type transdermal drug delivery system, comprising: a drug protecting layer; a first adhesive layer that is formed on the drug protecting layer and comprises 20-75 wt % of an adhesive comprising a water-insoluble acrylic polymer, 0.1-10 wt % of a nonionic surfactant, 0.1-15 wt % of an alcohol having a molecular weight of 600 Daltons or less, and 0.1-5 wt % of a solubilizing agent comprising a hydrophilic polymer said first adhesive layer absent an active component; a drug containing layer that is formed on the first adhesive layer and comprises 0.1-25 wt % of one material or a mixture of two or more materials selected from the group consisting of capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, homocapsaicin, capsazepine, N-vanillylnonanamide, (Z)-capsaicin, (E)-capsaicin, and 6-iodonordihydrocapsaicin, 0-5 wt % of a nonionic surfactant, 1-15 wt % of an alcohol having a molecular weight of 600 Daltons or less, and 0.1-5 wt % of a solubilizing agent comprising a hydrophilic polymer; a second adhesive layer that is formed on the drug containing layer and comprises 20-75 wt % of an adhesive including a water-insoluble acrylic polymer, 0.1-10 wt % of a nonionic surfactant, 0.1-15 wt % of an alcohol having a molecular weight of 600 Daltons or less, and 0.1-5 wt % of a solubilizing agent comprising a hydrophilic polymer said second adhesive layer absent an active component; and a release liner formed on the second adhesive layer, wherein the concentrations of the components are based on the total weight of the first adhesive layer, the drug containing layer, and the second adhesive layer, wherein the alcohol in the first adhesive layer, the drug containing layer, and the second adhesive layer is present in a weight ratio of 1:1-6:0.5-3 respectively, wherein the nonionic surfactant in the first adhesive layer, the drug containing layer, and the second adhesive layer is present in a weight ratio of 1:0-1:0.5-2 respectively, wherein the solubilizing agent in the first adhesive layer, the drug containing layer, and the second adhesive layer is present in a weight ratio of 1:0.1-1:0.2-5 respectively, and wherein said first adhesive layer, drug containing matrix layer and second adhesive layer are laminated in order.