Patent ID: 6900213

Claim:
A bisaryl derivative of the formula I, wherein (R,R) is selected from (H,H), O, (H,CH 3 ), (H,OH) and (H,CN); and wherein A is a group of formula II or III: wherein n is 1, R 1 is H, (C 1 -C 6 )alkyl; V is CH; W is CR 2 ′; R 2 and R 2 ′ are independently H, (C 1 -C 4 )alkyl or —CH 2 OH; R 3 is (C 1 -C 15 ) alkyl, which may optionally be branched or unbranched and optionally may contain a double or triple bond at one or more positions, or R 3 is —(CH 2 ) q —O—(C 1 -C 4 )alkyl, —(CH 2 ) q —(C 3 -C 8 )cycloalkyl, —(CH 2 ) q -tetrahydrofuranyl, —(CH 2 ) q -thiophenyl, —(CH 2 ) q -1,4-benzodioxol-6-yl, —(CH 2 ) q -phenyl, —(CH 2 ) q —S-phenyl, or —(CH 2 ) q —O-phenyl, wherein phenyl may be optionally substituted with (C 1 -C 6 )alkyl, (C 1 -C 4 ) alkoxy, halogen, amino, or dimethylamino, wherein q is an integer of 1-10; or R 3 is —(CH 2 ) x —C(O)—NR 5 —R 6 wherein R 5 is H or (C 1 -C 4 )alkyl, R 6 is —(CH 2 ) p —O—(C 1 -C 4 )alkyl, —(CH 2 ) p —(C 3 -C 8 )cycloalkyl, —(CH 2 ) p -tetrahydrofuranyl, —(CH 2 ) p -thiophenyl, —(CH 2 ) p -1,4-benzodioxol-6-yl, —(CH 2 ) p -phenyl, —(CH 2 ) p —S-phenyl, or —(CH 2 ) p —O-phenyl, wherein phenyl may be optionally substituted with (C 1 -C 6 )alkyl, (C 1 -C 4 ) alkoxy, halogen, amino, or dimethylamino, wherein x and p are integers, and x is ≧1 and p>1 and x+p=3-8; or R 3 is —(CH 2 ) y —C(O)—NR 5 —(C 1 -C 12 )alkyl, wherein the alkyl moiety may optionally be branched or unbranched and optionally may contain a double or triple bond at one or more positions, R 5 is as previously defined, y is an integer of 1-12 and the maximal chain length of R 3 is 15 atoms; and Ar is of the formula VI or VII: wherein (i) X, Y, Z are independently H, OH, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, provided that at least one of X, Y and Z is not H; or (ii) two of X, Y and Z are H, the other being —CHO, —CH 2 —NR 7 —CH 2 —R 8 or —CH 2 —NR 7 —CO—R 8 , wherein R 7 is H, (C 1 -C 6 )n-alkyl or —(CH 2 ) m —O—(C 1 -C 4 )alkyl; R 8 is (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxy—(C 1 -C 4 )alkyl, amino or (C 1 -C 4 )alkyl—NH—; and m being 2-6; and (iii) T is —CH 2 —NR 9 R 10 , wherein R 9 is (C 1 -C 6 )n-alkyl and R 10 is (C 2 -C 5 )acyl, (C 1 -C 4 )alkoxycarbonyl or (C 1 -C 4 )alkyl—NH—CO—.