Patent ID: 8648208

Claim:
A compound having the following formula (I) or a pharmacologically acceptable salt thereof: wherein: R 1 is hydrogen, halogen, hydroxyl, nitro, amino, cyano, carboxyl, C 1-8 alkyl, cycloalkyl of three-membered to seven-membered ring, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkyl substituted with cycloalkyl of three-membered to seven-membered ring, C 1-8 alkyl substituted with halogen, C 1-8 alkyl substituted with C 1-8 alkoxy, C 1-8 alkoxy substituted with halogen, C 2-8 acyl, C 6-10 aryl, a heterocyclic group of five-membered or six-membered ring, aralkyl consisting of C 6-10 aryl and C 1-8 alkylene, or C 1-8 alkyl substituted with a heterocyclic group of five-membered or six-membered ring; R 2 is hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 1-8 alkyl substituted with cycloalkyl of three-membered to seven-membered ring, C 1-8 alkyl substituted with halogen, C 1 - 8 alkyl substituted with C 1-8 alkoxy, C 2-8 acyl, C 6-10 aryl, or aralkyl consisting of C 6-10 aryl and C 1-8 alkylene; each of R 3 , R 4 , R 5 , and R 6 independently is hydrogen, C 1-8 alkyl, or C 1-8 alkyl substituted with halogen; X is sulfur; Y is a bond: p is 0 or 1: A is oxygen, CH 2 , N—NH 2 or N—OR 9 , wherein R 9 is hydrogen, C 1-8 alkyl, C 1-8 alkyl substituted with halogen, C 2-8 acyl, C 2-8 alkenyl, or aralkyl consisting of C 6-10 aryl and C 1-8 alkylene; when p is 1, B is phenyl, which can have a substituent selected from the group consisting of halogen, hydroxyl, nitro, amino, C 1-8 alkyl, cycloalkyl of three-membered to seven-membered ring, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkyl substituted with cycloalkyl of three-membered to seven-membered ring, C 1-8 alkyl substituted with halogen, C 1-8 alkyl substituted with C 1-8 alkoxy, C 1 - 8 alkoxy substituted with halogen, C 2-8 acyl, C 6-10 aryl, or aralkyl consisting of C 6-10 aryl and C 1-8 alkylene; when p is 0, B is a condensed ring selected from the group consisting of indole, benzofuran, benzisoxazole, or 1,2-benzisothiazole, each of which can have a substituent selected from the group consisting of halogen, hydroxyl, nitro, amino, C 1 - 8 alkyl, cycloalkyl of three-membered to seven-membered ring, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkyl substituted with cycloalkyl of three-membered to seven-membered ring, C 1-8 alkyl substituted with halogen, C 1-8 alkyl substituted with C 1-8 alkoxy, C 1-8 alkoxy substituted with halogen, C 2-8 acyl, C 6-10 aryl, or aralkyl consisting of C 6-10 aryl and C 1-8 alkylene, wherein Y binds to the benzene ring of B, and —(C(R 3 )(R 4 ))m- binds to the condensed ring at the 3-position of B; m is an integer of 1 to 4; n is an integer of 0 to 5; and when n is 0, Y is a bond.