Patent ID: 8278467

Claim:
A process for the preparation of a compound of formula (7): wherein R is one of the following: and wherein R 1 is hydrogen, a protecting group or a substituted or unsubstituted hydrocarbyl group; R 2 is a substituted or unsubstituted acyl group; R 3 is a substituted or unsubstituted acyl group; said process comprises: a) hydroxylating a compound of formula (1): wherein Y is a halo group, P 1 is hydrogen or a protecting group, and W is ═O or —OP 2 , wherein P 2 is hydrogen or a protecting group, to provide a compound of formula (2): b) oxidizing the compound of formula (2) to provide a compound of formula (3): c) coupling the compound of formula (3) with a compound of formula (4): wherein Z is (PR 11 R 12 ) + X − or P(═O)R 11 R 12 , wherein X is an anion and R 11 and R 12 are each independently an alkyl, aryl, alkoxy or aryloxy group, to provide a compound of formula (5): wherein when W is —OP 2 , removing at least a portion of the P 2 protecting group and oxidizing the compound of formula (5) to provide a compound of formula (6): and d) subjecting the compound of formula (5) when W is ═O, or the compound of formula (6) to ring-opening, removing at least a portion of the P 1 protecting group, and optionally removing at least a portion of additional protecting groups to provide a compound of formula (7).