Patent ID: 6890725

Claim:
A method of screening for an immunosuppressant, comprising: a) combining a candidate bioactive agent and a myosin-1F protein, wherein said myosin-1F protein has at least 95% identity to SEQ ID NO:2; b) detecting modulation in the ATPase activity of said myosin-1F protein in the presence of said candidate bioactive agent; c) contacting said candidate bioactive agent to a B-lymphocyte; d) inducing activation of said lymphocyte; and e) determining the activation of said lymphocyte in the presence of said candidate bioactive agent; wherein said myosin-1F protein exhibits ATPase activity in the absence of said candidate bioactive agent, and wherein a decrease in the activation of said lymphocyte in the presence of said candidate bioactive agent indicates that said candidate bioactive agent is an immunosuppressant.