Patent ID: 8324184

Claim:
A composite comprising (1) a first compound comprising, the reaction product between a thiolated compound having at least one SH group with at least one first anti-adhesion compound having at least one thiol-reactive electrophilic functional group, and (2) a first prohealing compound, wherein the thiolated compound comprises the formula III wherein L is a polyalkylene group, a polyether group, a polyamide group, a polyimino group, a polyester, an aryl group, or a polythioether group; and Y is a residue of carboxymethylcellulose, hyaluronan, or a chemically modified-derivative of hyaluronan; the first anti-adhesion compound comprises an anti-cancer drug, an anti-proliferative drug, a PKC inhibitor, an ERK or MAPK inhibitor, a cdc inhibitor, an antimitotic, a DNA intercalator, a covalent modifier of DNA, an anti-inflammatory compound, or an inhibitor of PI3 kinase; and the first prohealing compound is a polysaccharide selected from the group consisting of chondroitin sulfate, dermatan, heparan, heparin, dermatan sulfate, heparan sulfate, alginic acid, pectin, carboxymethylcellulose, and hyaluronan.