Patent ID: 8008479

Claim:
A process for preparing compounds of formula I or a solvate or hydrate thereof, where R is phenyl that is unsubstituted or is substituted by 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 7 -alkyl, trifluoromethyl, hydroxy and C 1 -C 7 -alkoxy; R 1 is hydrogen or C 1 -C 7 -alkyl; R 2 is hydrogen, C 1 -C 7 -alkyl or phenyl that is unsubstituted or is substituted by 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 7 -alkyl, trifluoromethyl, hydroxy and C 1 -C 7 -alkoxy; R 3 is phenyl that is unsubstituted or is substituted by 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 7 -alkyl, trifluoromethyl, hydroxy and C 1 -C 7 -alkoxy, or R 3 is naphthyl, 1H-indol-3-yl or 1-C 1 -C 7 -alkyl-indol-3-yl; and R 5 is C 3 -C 8 -cycloalkyl, D-azacycloheptan-2-on-3-yl or L-azacycloheptan-2-on-3-yl, the process comprising the steps of: (a) reacting a compound of formula II where R 1 , R 2 , R 3 and R 5 are as defined in this claim above and T is a BOC protecting group, with a base to form a compound of formula III where R 1 , R 2 , R 3 and R 5 are defined in this claim above; and (b) reacting a compound of formula III where R 1 , R 2 , R 3 and R 5 are as defined in this claim above with a compound of formula IV where R is phenyl that is unsubstituted or is substituted by 1, 2 or 3 substituents selected from the group consisting of halogen, C 1 -C 7 -alkyl, trifluoromethyl, hydroxy and C 1 -C 7 -alkoxy, and X is halo, in the presence of a base to form a compound of formula I, and (c) optionally, forming a desired solvate or hydrate thereof.