Patent ID: 7868021

Claim:
A compound having the following formula: wherein: (a) X is selected from the group consisting of (b) R1 is selected from the group consisting of C 3 to C 5 cycloalkyl, C 1 to C 2 alkanyl, C 2 to C 3 linear alkenyl, C 3 to C 4 branched alkanyl or alkenyl, all such alkyl or cycloalkyl moieties being unsubstituted or substituted with from 1 to 3 fluoro; and phenyl, unsubstituted or substituted with from 1 to 3 fluoro, or with one hydroxy in the 4-position; (c) R3 is hydrogen or hydroxy; (d) R5 is selected from the group consisting of hydrogen, hydroxy, amino, halo, C 1 to C 2 alkanyl, C 2 alkenyl, and methoxy, all such alkyl and methoxy moieties being unsubstituted or substituted with from 1 to 3 fluoro; (e) R6 is hydrogen; (f) R8 is selected from the group consisting of chloro, bromo, methoxy, methylthio, C 1 to C 2 alkanyl, C 2 to C 4 alkenyl, all such alkyl, methoxy and methylthio moieties being unsubstituted or substituted with from 1 to 3 fluoro; (g) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C 1 to C 3 alkanyl; or aminoalkanyl which is attached to any ring carbon of X and is C 1 to C 3 alkanyl substituted with one amino, the amino being unsubstituted or substituted with one or two C 1 to C 3 alkanyl; (h) each R9 is independently selected from the group consisting of hydrogen, C 1 to C 4 alkanyl, C 2 to C 6 alkenyl or alkynyl, and a C 3 to C 6 fused or spirocycle alkyl ring, all such alkyl moieties being unsubstituted or substituted with from 1 to 3 fluoro; and (j) a R7 moiety described in (g) and a R9 moiety described in (h) may optionally be connected thus forming a fused or spirocycle ring with the N-containing ring shown in (a), the fused or spirocycle ring comprising from 2 to 5 ring carbons and 0 or 1 ring nitrogen, but if such rings are fused, R8 is other than chloro or bromo; an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.