Patent ID: 7084140

Claim:
A compound of Formula I wherein: Ar is an unsubstituted or mono- to penta-substituted phenyl, or unsubstituted or mono- or disubstituted naphthyl, wherein the substituents of the phenyl and naphthyl group of Ar independently of one another are selected from F, Cl, Br, I, (C 1-4 )alkyl, O—(C 1-4 )alkyl, CF 3 , OCF 3 , or NR 12 R 13 wherein R 12 and R 13 independently of one another are H, methyl, or acetyl, or Ar is phenyl substituted by —O—CH 2 —O— or —O—(CH 2 ) 2 —O—; R 1 and R 2 together with the N to which they are bound are a ring of the formula R 7 has one of the definitions (a) to (d): (a) hydroxy, (b) 4-piperidinopiperidyl, wherein R 16 and R 17 independently of one another are H, (C 1-4 )alkyl, (C 3-6 )cycloalkyl, hydroxy(C 2-4 )alkyl, (C 1-3 )alkoxy(C 2-4 )alkyl, phenyl(C 1-4 )alkyl, or di(C 1-3 )alkylamino(C 2-4 )alkyl, or if R 16 is H or (C 1-4 )alkyl, R 17 is also —CH 2 C(O)NR 18 R 19 , wherein: R 18 is H or (C 1-4 )alkyl, and R 19 is H, (C 1-4 )alkyl, (C 3-6 )cycloalkyl, hydroxy(C 2-4 )alkyl, alkoxy(C 2-3 )alkyl, phenyl(C 1-4 )alkyl, or R 18 and R 19 together with the N to which they are bound form a 1-pyrrolidinyl, piperidino, morpholino, or 1-methylpiperazin-4-yl ring; wherein R 20 is H, (C 1-4 )alkyl, (C 4-6 )cycloalkyl, or —CH 2 C(O)NR 21 R 22 , wherein: R 21 is H or (C 1-4 )alkyl, and R 22 is H, (C 1-4 )alkyl, (C 3-6 )cycloalkyl, hydroxy(C 2-4 )alkyl, alkoxy(C 2-3 )alkyl, phenyl(C 1-4 )alkyl; R 3 is H or (C 1-4 alkyl; R 4 is phenyl(C 1-4 )alkyl or naphthyl(C 1-4 )alkyl, wherein phenyl is optionally substituted by 1 to 3 substituents, wherein the substituents independently of one another are F, Cl, Br, I, (C 1-4 )alkyl, O—(C 1-4 )alkyl, CF 3 , OCF 3 , or NR 27 R 28 wherein R 27 and R 28 independently of one another are H, methyl, or acetyl; and R 5 is H, (C 1-4 )alkyl, (C 3-6 )cycloalkyl, CH 2 COOH, CH 2 C(O)NH 2 , OH or phenyl(C 1-4 )alkyl, or a pharmaceutically acceptable salt thereof.