Patent ID: 8598123

Claim:
A compound of formula INT1 whereby Ar 1 is phenyl substituted by two or more substituents independently selected from OH, C 1-3 alkyl and halogen, or Ar 1 is phenyl fused to a 5- or 6-membered heterocycle optionally substituted by one or more substituents independently selected from halogen, OH and ═O, Ar 2 is phenyl optionally substituted by one or more substituents independently selected from OH, C 1-3 alkyl and halogen, or Ar 2 is phenyl fused to a 5- or 6-membered heterocycle optionally substituted by one or more substituents independently selected from halogen, OH, and ═O, Gu is guanidinyl (or a tautomeric form thereof) optionally substituted by up to 4 substituents independently selected from C 1-3 alkyl, R 1 is independently H or C 1-5 alkyl optionally substituted by Y, where Y is halogen, S(O) m —(C 1-3 alkyl), CO 2 —R 5 or Gu, where R 5 is H or C 1-6 alkyl, and m is 0, 1 or 2, R 2 is independently H or C 1-3 alkyl, or R 1 and R 2 together with the carbon atom to which they are attached can be a cyclopropyl group, one of R 3 and R 4 is H and the other is Q where Q is NH 2 , NHC(O)(C 1-6 alkyl), Gu, NHC(O)(CH 2 ) n NH 2 , NHC(O)(CH 2 ) n Gu, or (CH 2 ) n Gu, where n is 1, 2, 3, 4 or 5, or a tautomer thereof.