Patent ID: 8877191

Claim:
A method of treating a P. aeruginosa infection in a patient, the method comprising administering a therapeutically effective amount of an anti-PcrV antibody that selectively binds PcrV to a patient infected with P. aeruginosa , wherein the antibody has a K D of less than 50 nM when assayed as a Fab and comprises: a V L region that has a CDR3 having a sequence Q(Q/H)FWGTPYT (SEQ ID NO:41); a CDR1 having a sequence RASEGVDRWLA (SEQ ID NO:69) or RASQSISRWVA (SEQ ID NO:68); and a CDR2 having a sequence, DASTLQS (SEQ ID NO:73) or DASSLKS (SEQ ID NO:71); and a V H region that has a CDR3 having a sequence NRGDIYYDFTYA(M/F)DX 1 (SEQ ID NO:42), wherein X 1 is I, Q, Y or S; a CDR1 having a sequence NYPMH (SEQ ID NO:54) or SYPLH (SEQ ID NO:53); and a CDR2 having a sequence VISYDGSEKWYADSVKG (SEQ ID NO:57) or FISYDGSEKYYASSVKG (SEQ ID NO:56).