Patent ID: 8071774

Claim:
A compound of the general formula having a specific configuration at the asymmetric carbon atom labeled â€œ*â€, in which A is aryl; U is â€”C(R 3 )(R 4 )â€”, S(O) m â€”, â€”N(R 5 )â€” or a bond; V is â€”C(R 3 )(R 4 )â€” or a) if U is either a bond or â€”C(R 3 )(R 4 )â€”, V is alternatively â€”S(O) m â€” or â€”N(R 5 )â€”, b) if U is â€”S(O) m â€”, V is alternatively â€”N(R 5 )â€”, or c) if U is â€”N(R 5 )â€”, V is alternatively â€”S(O) m â€”; W is â€”C(R 3 )(R 4 )â€” or a) if U is either a bond or â€”C(R 3 )(R 4 )â€” and V is â€”C(R 3 )(R 4 )â€”, W is alternatively â€”Oâ€”, â€”S(O) m â€” or â€”N(R 5 )â€”, b) if U is either a bond or â€”C(R 3 )(R 4 )â€” and V is â€”S(O) m â€”, W is alternatively â€”N(R 5 )â€”, c) if U is either a bond or â€”C(R 3 )(R 4 )â€” and V is â€”N(R 5 )â€”, W is alternatively â€”S(O) m â€”, or d) if U is â€”N(R 5 )â€” and V is â€”C(O)â€”, W is alternatively â€”N(R 5 )â€”; R is hydrogen, C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy-C 0 -C 4 -alkyl, halogen, tri-C 1 -C 4 -alkylsilyl, deuterium or trifluoromethyl; R 1 is C 1 -C 8 -alkyl, C 0 -C 8 -alkylcarbonyl, amino, mono- or di-C 1 -C 8 -alkylamino, C 0 -C 8 -alkyl-carbonylamino, C 0 -C 8 -alkylcarbonyl-C 1 -C 8 -alkylamino, carbamoyl, mono- or di-C 1 -C 8 -alkyl-aminocarbonyl, carboxyl, carboxy-C 1 -C 4 -alkyl, halogen, cyano, oxo, trifluoromethyl, trifluoromethoxy, C 1 -C 8 -alkoxy, or C 1 -C 8 -alkoxycarbonyl, which radicals may be substituted by 1-4 C 1 -C 8 -alkyl, C 0 -C 8 -alkylcarbonyl, halogen, cyano, oxo, trifluoromethyl, C 0 -C 8 -alkylcarbonylamino, C 0 -C 8 -alkylcarbonyl-C 1 -C 8 -alkylamino, carbamoyl, mono- or di-C 1 -C 8 -alkylaminocarbonyl, carboxy-C 0 -C 4 -alkyl, C 1 -C 8 -alkoxy, or C 1 -C 8 -alkoxycarbonyl, R 2 is hydrogen, C 1 -C 8 -alkyl, C 0 -C 8 -alkylcarbonyl, amino, mono- or di-C 1 -C 8 -alkylamino, C 0 -C 8 -alkylcarbonylamino, C 0 -C 8 -alkylcarbonyl-C 1 -C 8 -alkylamino, carbamoyl, mono- or di-C 1 -C 8 -alkylaminocarbonyl, carboxyl, carboxy-C 1 -C 4 -alkyl, halogen, cyano, oxo, trifluoromethyl, trifluoromethoxy, C 1 -C 8 -alkoxy, or C 1 -C 8 -alkoxycarbonyl, which radicals may be substituted by 1-4 C 1 -C 8 -alkyl, C 0 -C 8 -alkylcarbonyl, halogen, cyano, oxo, trifluoromethyl, trifluoromethoxy, C 0 -C 8 -alkylcarbonylamino, C 0 -C 8 -alkylcarbonyl-C 1 -C 8 -alkylamino, carbamoyl, mono- or di-C 1 -C 8 -alkylaminocarbonyl, carboxy-C 0 -C 4 -alkyl, C 1 -C 8 -alkoxy, or C 1 -C 8 -alkoxycarbonyl; R 3 is hydrogen or C 1 -C 8 -alkyl; R 4 a) is hydrogen or C 1 -C 8 -alkyl; or b) together with R 3 is oxo; R 5 is hydrogen, C 1 -C 8 -alkyl or C 0 -C 8 -alkylcarbonyl; m is a number 0, 1 or 2; p is is a number 1; or its pharmaceutically useful salt.