Patent ID: 6951860

Claim:
A method for inhibiting calcium channel activity in a cell having a calcium channel comprising: contacting the cell having the calcium channel with a compound in an amount effective to inhibit calcium channels, wherein the compound has the general structural formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 7 , R 8 , R 9 , and R 10 independent of one another, are selected from the group consisting of —H, halogen, piperonyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkenyl, (C 1 -C 6 ) alkynyl, (C 1 -C 6 ) alkoxy —CN, —OR′, —SR′, —NO 2 , —NR′R′, amino acid, —C(O)R′, —C(S)R′, —C(O)OR′, —C(S)OR′, —C(O)SR, —C(S)SR′, —C(O)N(R′) 2 , —C(O)C(O)R′, —C(S)C(O)R′, —C(O)C(S)R′, —C(S)C(S)R′, —C(O)C(O)OR′, —C(S)C(O)OR′, —C(O)C(S)OR′, —C(O)C(O)SR′, —C(S)C(S)OR′, —C(S)C(O)SR′, —C(O)C(S)SR′, —C(S)C(S)SR′, —C(O)C(O)N(R′) 2 , —C(S)C(O)N(R′) 2 , —C(O)C(S)N(R′) 2 , or —C(S)C(S)N(R′) 2 ; wherein R 11 is selected from the group consisting of —NH—CH 2 CH 2 NH 2 , —NH—CH 2 CH 2 N—(CH 2 ) z —H, —N.(CH 2 ) 2 N R 15 .(CH 2 ) 2 , —R′, —OR′, —SR′, —NO 2 , —N(R′) 2 , —CO—R′, —CS—R′, —CO—OR′, —CS—OR′, —CO—SR′, —CS—SR′, —CO—N(R′) 2 , and —CS—N(R′) 2 ; wherein each R′ is (CH 2 ) z —NR″R″ and wherein R″ is independently selected from the group consisting of (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkenyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkynyl, (C 6 -C 20 ) aryl, (C 6 -C 20 ) substituted aryl, (C 6 -C 26 ) alkaryl, substituted (C 6 -C 26 ) alkaryl, and (C 5 -C 7 ) heteroaryl wherein at least one atom of the heteroaryl is selected from the group consisting of a sulfur, a nitrogen, or an oxygen atom, wherein the aryl and alkaryl substituents are each independently selected from the group consisting of hydrogen, halogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkenyl, (C 1 -C 6 ) alkynyl and trihalomethyl; wherein z is 1-6; wherein R 15 is selected from the group consisting of halogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkenyl, (C 1 -C 6 ) alkynyl, and (C 1 -C 6 ) alkoxy; wherein X is a group having the following formula; —(CH 2 ) m —Y—(CH 2 ) n — wherein Y is selected from the group consisting of S, N, and O; and wherein m and n, independent of one another, are integers of 0-5.