Patent ID: 7345020

Claim:
A macrocyclic peptidomimetic corresponding to a tetrameric, pentameric or hexameric peptide, having a 10-member ring according to the formula: wherein: R 1 is the α-carbon, amino moiety and side chain of the amino terminal amino acid of a tetrameric peptidomimetic or the amino terminal amino acid and the α-carbon, amine and side chain of the second amino acid of a pentameric or hexameric peptidomimetic; R 2 is the side-chain of the second amino acid of a tetrameric or pentameric peptidomimetic or the side-chain of the third amino acid of a pentameric or hexameric peptidomimetic; R 3 is the side chain of the third amino acid of a tetrameric or pentameric peptidomimetic or the fourth amino acid of a pentameric or hexameric peptidomimetic; and R 4 and 4−N together are the carboxyl terminal amino acid of a tetrameric or pentameric peptidomimetic, or the carboxyl terminal two amino acids of a pentameric or hexameric peptidomimetic; and the sequence of amino acids to which R 1 through R 4 correspond are selected from the following sequences: *-N-Q-L-I-+ SEQ ID NO:7 *-N-Q-L-I-K-+ SEQ ID NO:8 *-N-Q-I-K-+ SEQ ID NO:9 *-S-N-Q-L-+ SEQ ID NO:10 *-S-N-Q-L-I-+ SEQ ID NO:11 *-S-N-Q-L-I-K-+ SEQ ID NO:12 *-S-N-Q-I-+ SEQ ID NO:13 *-S-N-Q-I-K-+ SEQ ID NO:14 *-N-S-N-Q-+ SEQ ID NO:15 *-N-S-N-Q-L-+ SEQ ID NO:16 *-N-S-N-Q-L-I-+ SEQ ID NO:17 *-N-S-N-Q-I-K-+ SEQ ID NO:19 *-N-S-N-Q-I-+ SEQ ID NO:1 *-K-N-S-N-+ SEQ ID NO:20 *-K-N-S-N-Q-+ SEQ ID NO:21 *-K-N-S-N-Q-L-+ SEQ ID NO:22 *-K-N-S-N-Q-I-+ SEQ ID NO:2 *-E-N-K-E-+ SEQ ID NO:24 *-E-N-K-E-A-+ SEQ ID NO:25 *-L-E-N-K-+ SEQ ID NO:26 *-L-E-N-K-E-+ SEQ ID NO:27 *-L-E-N-K-E-A-+ SEQ ID NO:28 *-K-L-E-N-K-+ SEQ ID NO:29 *-K-L-E-N-K-E-+ SEQ ID NO:30 *-S-G-Q-V-+ SEQ ID NO:31 *-S-G-Q-V-L-+ SEQ ID NO:32 *-D-S-G-Q-+ SEQ ID NO:33 *-D-S-G-Q-V-+ SEQ ID NO:34 *-D-S-G-Q-V-L-+ SEQ ID NO:35 *-S-D-S-G-Q-+ SEQ ID NO:36 *-S-D-S-G-Q-V-+ SEQ ID NO:37 and *-L-S-D-S-G-Q-+, SEQ ID NO:39 wherein * denotes the amino terminal and + the carboxyl terminal.