Patent ID: 7371722

Claim:
A pharmaceutical composition comprising: (A) human prothrombin, (B) human coagulation factors V, VIII, IX, X, which may at least partially be present in activated form, and human coagulation factor XIa, and (C) a mixture of phospholipids where the phospholipids are selected from the group consisting of choline-phospholipids, serine-phospholipids, and ethanolamine-phospholipids, where the phospholipids are contained in liposomes, wherein said pharmaceutical composition (i) the presence of an effective amount of calcium ion activity generates thrombin and (ii) when the product of (i) is mixed with a medicinal product containing fibrinogen, results in a mixture which coagulates within 30 to 300 seconds and is suitable for use as a tissue glue or tissue sealant.