Patent ID: 7732628

Claim:
A compound that has formula (I): P 1 -M-X wherein: P 1 is a phosphorous based coupling group selected from the group consisting of phosphoramidite, H-phosphonate and phosphotriester; X is selected from the group consisting of: —NHNH—R 4 , —NHN═C(CH 3 ) 2 , —(C═O)CH 3 , —(C═O)H and —ONHR 4 wherein R 4 is a protecting group; and M is a divalent group of the formula —(CH 2 ) n —NH—(C═R 1 )—R 2 — wherein R 1 is S or O; R 2 is pyrimidinyl group, a quinolinyl group or a pyrrolyl group; and n is 2, 3, 4, 5, 6, 7, 8, 9, or 10.