Patent ID: 7585845

Claim:
A racemate, diastereoisomer, or optical isomer of a compound of formula (I): wherein B is (C 1-10 )alkyl, (C 3-7 )cycloalkyl, or (C 1-4 )alkyl-(C 3-7 )cycloalkyl, a) wherein said alkyl, cycloalkyl, and alkyl-cycloalkyl may be mono-, di- or tri-substituted with (C 1-3 )alkyl; and b) wherein said alkyl, cycloalkyl, and alkyl-cycloalkyl may be mono- or di-substituted with substituents selected from hydroxy and O—(C 1-4 )alkyl; and c) wherein each of said alkyl groups may be mono-, di- or tri-substituted with halogen; and d) wherein each of said cycloalkyl groups being 4-, 5-, 6- or 7-membered having optionally one (for the 4-, 5, 6, or 7-membered) or two (for the 5-, 6- or 7-membered) —CH 2 -groups not directly linked to each other replaced by —O— such that the O-atom is linked to the group X via at least two C-atoms; X is O or NH; R 3 is (C 2-8 )alkyl, (C 3-7 )cycloalkyl or (C 1-3 )alkyl-(C 3-7 )cycloalkyl, wherein said alkyl, cycloalkyl, and alkyl-cycloalkyl groups may be mono-, di- or tri-substituted with (C 1-4 )alkyl; L 0 is halogen, (C 1-4 )alkyl, —OH, —O—(C 1-4 )alkyl, —NH 2 , —NH(C 1-4 )alkyl or —N((C 1-4 )alkyl) 2 ; L 1 , L 2 are each independently halogen, cyano, (C 1-4 )alkyl, —O—(C 1-4 )alkyl, —S—(C 1-4 )alkyl, —SO—(C 1-4 )alkyl, or —SO 2 —(C 1-4 )alkyl, wherein each of said alkyl groups is optionally substituted with from one to three halogen atoms; and either L 1 or L 2 (but not both at the same time) may also be H; or L 0 and L 1 or L 0 and L 2 may be covalently bonded to form, together with the two C-atoms to which they are linked, a 5- or 6-membered carbocyclic ring wherein one or two —CH 2 -groups not being directly linked to each other may be replaced each independently by —O— or NR a wherein R a is H or (C 1-4 )alkyl, and wherein said carbo- or heterocyclic ring is optionally mono- or di-substituted with (C 1-4 )alkyl; R 2 is R 20 , —NR 22 COR 20 , —NR 22 COOR 20 , —NR 22 R 21 or —NR 22 CONR 21 R 23 , wherein R 20 is selected from (C 1-8 )alkyl, (C 3-7 )cycloalkyl and (C 1-4 )alkyl-(C 3-7 )cycloalkyl, wherein said cycloalkyl and alkyl-cycloalkyl may be mono-, di- or tri-substituted with (C 1-3 )alkyl; R 21 is H or R 20 as defined above, R 22 and R 23 are independently selected from H and methyl, R 1 is ethyl or vinyl; R C is hydroxy; or a pharmaceutically acceptable salt or ester thereof.