Patent ID: 8664392

Claim:
A compound of the formula: E1-L-Ar—X-PA (Formula IX), wherein: Ar is E1 is hydrogen; X is selected from a single bond, —(CH 2 ) a —, —CO—, —OCO—, —HNCO—, —(CH 2 ) a CO—, —(CH 2 ) a OCO—, C5-C10 aryl, C5-C10 heteroaryl, —NR 1 CO—, —(CH 2 ) a CONR 1 —, —(CH 2 ) a SO—, —(CH 2 ) a CON(R 1 )—, —(CH 2 ) a N(R 1 )CO—, —(CH 2 ) a N(R 1 )CON(R 2 )— and —(CH 2 ) a N(R 1 )CSN(R 2 )—, —CON(R 1 )(CH 2 ) a —; L is selected from a single bond, —HNCO—, —CONR 3 , —(CH 2 ) b —, —(CH 2 ) b CONR 3 —, —N(R 3 )CO(CH 2 ) b —, —OCO(CH 2 ) b —, —(CH 2 ) b CO 2 —, —OCONH—, —OCO 2 —, —HNCONH—, —HNCSNH—, —HNNHCO—, —OSO 2 —, —NR 3 (CH 2 ) b CONR 4 —, —CONR 3 (CH 2 ) b NR 4 CO—, —NR 3 CO(CH 2 ) b CONR 4 —, —(CH 2 ) b CON(R 3 )—, —(CH 2 ) b N(R 3 )CO—, —(CH 2 ) b N(R 3 )CON(R 4 )— and —(CH 2 ) b N(R 3 )CSN(R 4 )—; PA is —OZ or —NR 9 Z; Z is selected from —(CH 2 ) c CO 2 H, —(CH 2 ) c NR 9 R 10 , —(CH 2 ) c NCO, —(CH 2 ) c NCS, ——(CH 2 ) c SH, —(CH 2 ) c C≡CH, —(CH 2 ) c C≡N, —(CH 2 ) c N 3 , each R 1 , R 2 , R 3 , and R 4 is independently selected from hydrogen, C1-C10 alkyl, —OH, C5-C10 aryl, C1-C10 hydroxyalkyl, C1-C10 polyhydroxyalkyl, C1-C10 alkoxyl, C1-C10 alkoxyalkyl, —(CH 2 ) c CO 2 H, and —(CH 2 ) c NR 9 R 10 ; R 5 and R 6 are each independently —(CH 2 ) f NR 16 R 17 ; R 9 and R 10 are each independently selected from hydrogen, C1-C10 alkyl, C5-C10 aryl, and C1-C10 maleimidoalkylcarbonyl; R 16 and R 17 are each independently hydrogen, C 1 -C 10 alkyl, C5-C10 aryl, C 1 -C 10 hydroxyalkyl, and C 1 -C 10 alkoxyalkyl; each a is an integer independently selected from 0 to 10; each b is an integer independently selected from 0 to 10; each c is an integer independently selected from 0 to 10; and each f is an integer independently selected from 0 to 10.