Patent ID: 8486974

Claim:
An isosorbide aspirinate compound having the structure: wherein Y is selected from the group consisting of: (i) a C 1 -C 8 alkyl ester, a C 1 -C 8 alkoxy ester, a C 3 -C 10 cycloalkyl ester, an arylester or a C 1 -C 8 alkylaryl ester, which can be unsubstituted or substituted with at least one substituent selected from nitrate ester, C 1 -C 8 alkyl nitrate ester or a C 3 -C 10 cycloalkyl nitrate ester; (ii) a C 1 -C 8 alkyl ester or a C 1 -C 8 alkoxy ester, which can be unsubstituted or substituted with ONO 2 ; or a C 3 -C 10 cycloalkyl ester or a C 1 -C 8 cycloalkoxy ester, which can be unsubstituted or substituted with ONO 2 ; or an unsubstituted or a substituted arylester, alkylaryl ester, benzoate, a nicotinate oxazoleoate, isoxazoleate, thiadiazoleoate group, which may be substituted by at least one of the group comprising hydroxide, —Cl, —Br, a C 1 -C 8 alkyl, benzyl, a C 1 -C 8 alkoxy, benzyloxy, —NHC(O)R, —NH 2 , —NO 2 , —ONO 2 , —(CH 2 ) n ONO 2 , —OC(O)[(CH 2 ) m ] cyclic ONO 2 , —OCOArONO 2 , —OCOAr(CH 2 ) n ONO 2 or a C 1 -C 5 haloalkyl ester, wherein R is a C 1 -C 8 alkyl or a C 1 -C 8 alkoxy group, n=1-8, m=3-10; (iii) a C 1 -C 8 alkyl ester or a C 1 -C 8 alkoxy ester, which can be unsubstituted or substituted with ONO 2 ; or an unsubstituted or a substituted arylester, alkylaryl ester, benzoate, nicotinate, oxazoleoate, isoxazoleate, thiadiazoleoate group, which may be substituted by at least one of the group comprising hydroxide, —Cl, —Br, a C 1 -C 8 alkyl, benzyl, a C 1 -C 8 alkoxy, o-benzyloxy, —NHC(O)R, —NH 2 , —NO 2 , —ONO 2 , —(CH 2 ) n ONO 2 , —C(O)[(CH 2 ) m ] cyclic ONO 2 , —OCOArONO 2 , —OCOAr(CH 2 ) n ONO 2 or a C 1 -C 5 haloalkyl ester, wherein R is a C 1 -C 8 alkyl or a C 1 -C 8 alkoxy group, n=1-8, m=3-10; (iv) a C 1 -C 8 alkoxy ester, which can be unsubstituted or substituted with ONO 2 ; or an unsubstituted or a substituted benzoate or nicotinate group, which may be substituted by at least one of the group comprising hydroxide, —Cl, —Br, a C 1 -C 8 alkyl, benzyl, a C 1 -C 8 alkoxy, o-benzyloxy, —NHC(O)R, —NH 2 , —NO 2 , —ONO 2 , —(CH 2 ) n ONO 2 , —OC(O)[(CH 2 ) m ] cyclic ONO 2 , —OCOArONO 2 , —OCOAr(CH 2 ) n ONO 2 or a C 1 -C 5 haloalkyl ester, wherein R is a C 1 -C 8 alkyl or a C 1 -C 8 alkoxy group, n=1-8, m=3-10; (v) an unsubstituted or a substituted benzoate or nicotinate group, which may be substituted by at least one of hydroxide, C 1 -C 8 alkyl, C 1 -C 8 alkyoxy, o-benzyloxy, —(CH 2 ) n ONO 2 (n=1-8), C 3 -C 10 cycloalkyl ester or haloalkyl ester; and (vi) an unsubstituted or a substituted benzoate or nicotinate group, which may be substituted by at least one of hydroxide, —Cl, methyl, o-benzyloxy, methoxy, —NHC(O)CH 3 , —OC(O)CH 2 Br, —NO 2 , —CH 2 ONO 2 , wherein Y is an unsubstituted or a substituted benzoate or nicotinate group, which may be substituted by at least one of hydroxide, —Cl, methyl, o-benzyloxy, methoxy, —NHC(O)CH 3 , —OC(O)CH 2 Br, —NO 2 , —CH 2 ONO 2 ; wherein the isosorbide aspirinate compound is not a compound having the structure: