Patent ID: 7625933

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from (a) —X-Aryl-Y-Z, and (b) —X-Heteroaryl-Y-Z, wherein Aryl and Heteroaryl are optionally substituted with 1-3 groups independently selected from A, where A can be on any position of Heteroaryl when R 1 is —X-Heteroaryl-Y-Z; Aryl is phenyl or naphthyl; Heteroaryl is a monocyclic or fused bicyclic aromatic ring containing 1-4 heteroatoms independently selected from N, O and S, including —S(O)— and —S(O) 2 —, wherein each ring contains 5 to 6 atoms; X and Y are independently selected from the group consisting of a bond and —CR 5 R 6 —; Z is Q is selected from the group consisting of S and O; A is selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, —OC 1 -C 4 alkyl, and halogen, wherein alkyl, alkenyl, and —Oalkyl are each optionally substituted with 1-5 halogens; R 2 is C 1 -C 4 alkyl, which is optionally substituted with 1-5 halogens; R 3 is selected from the group consisting of (a) Benzisoxazolyl, (b) Aryl, (c) —C(═O)Aryl, (d) —OAryl, and (e) —S(O) n Aryl, wherein R 3 is optionally substituted with 1-3 substituent groups independently selected from halogen, C 1 -C 3 alkyl, and —OC 1 -C 3 alkyl, wherein C 1 -C 3 alkyl and —OC 1 -C 3 alkyl are optionally substituted with 1-5 halogens; R 4 , R 5 , and R 6 are independently selected from the group consisting of hydrogen, halogen, C 1 -C 3 alkyl, and —OC 1 -C 3 alkyl, wherein C 1 -C 3 alkyl and —OC 1 -C 3 alkyl are optionally substituted with 1-5 halogens; R 7 is selected from the group consisting of H, C 1 -C 3 alkyl, and halogen, wherein C 1 -C 3 alkyl is optionally substituted with 1-3 F; R 8 is selected from the group consisting of H and CH 3 ; n is an integer from 0 to 2; and p is an integer from 0 to 3.