Patent ID: 8883752

Claim:
An oligomeric compound comprising one monomer of Formula IV: wherein: Bx is a heterocyclic base moiety; T 7 is a phosphorus moiety having the formula: wherein: R a and R c are each, independently, OH, SH, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, substituted C 1 -C 6 alkoxy, amino or substituted amino; and R b is O or S; T 8 is an internucleoside linking group linking the monomer of Formula IV to the oligomeric compound; Q 1 , Q 2 , Q 3 and Q 4 are each, independently, H, halogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl; G 1 is O—[C(R 2 )(R 3 )] n —[(C═O) m —X] j —Z or halogen; each R 2 and R 3 is, independently, H or halogen; X is O, S or N(E 1 ); Z is H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl or N(E 2 )(E 3 ); E 1 , E 2 and E 3 are each, independently, H, C 1 -C 6 alkyl or substituted C 1 -C 6 alkyl; n is from 1 to about 6; m is 0 or 1; j is 0 or 1; each substituted group comprises one or more optionally protected substituent groups independently selected from halogen, OJ 1 , N(J 1 )(J 2 ), =NJ 1 , SJ 1 , N 3 , CN, OC(=L)J 1 , OC(=L)N(J 1 )(J 2 ) and C(=L)N(J 1 )(J 2 ); L is O, S or NJ 3 ; each J 1 , J 2 and J 3 is, independently, H or C 1 -C 6 alkyl; provided that when j is 1 then Z is other than N(E 2 )(E 3 ); provided that when Q 1 , Q 2 , Q 3 and Q 4 are each H then G 1 is other than H or OH; and wherein said oligomeric compound comprises from 8 to 40 monomeric subunits and is complementary to at least a portion of a nucleic acid target.