Patent ID: 8420637

Claim:
A method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person suffering from ocular hypertension or glaucoma an effective amount of a compound having the following formula wherein a dotted line represents the presence or absence of a double bond, wherein when said dotted line the represents the absence of a double bond, R 3 , R 5 , R 6 and R 7 are all present, and when said dotted line represents the presence of double bond only one of R 3 and R 5 and one of R 6 and R 7 are present; R is H, halogen or C 1-5 alkyl; R 1 is H or halogen; R 2 is H, C 1-5 alkyl, halogen, XC 1-5 alkyl, C 1-5 alkylOR 13 , C 1-5 alkylN(R 13 ) 2 , N(R 13 ) 2 , XC 1-5 alkylN(R 13 ) 2 , or XC 1-5 alkylO—R 13 ; wherein X is O or S(O)n; n is 0 or an integer of from 1 to 2; R 3 is H, hydroxyl, C 1-5 alkyl, C 1-5 alkylOR 13 , or C 1-5 alkylN(R 13 ) 2 ; R 4 is H, C 2-5 alkenyl, C 1-5 alkyl, C 1-5 alkylOR 13 , or C 1-5 alkylN(R 13 ) 2 ; R 5 is H, O, C 1-5 alkyl, C 1-5 alkylOR 13 , or OR 13 ; R 6 , R 7 , R 9 , R 10 , R 11 , and R 12 are independently H, C 1-5 alkyl, C 1-5 alkylOR 13 , or OR 13 ; R 13 is H, C 1-5 alkyl, or C 3-8 cyclic alkyl; and Y is OH.