Patent ID: 8278103

Claim:
An oligonucleotide comprising alternating first and second segments, wherein: said first segment consists of all arabinonucleotides and comprises at least one arabinonucleotide said second segment consists of all 2′-deoxyribonucleotides and comprises at least one 2′-deoxyribonucleotide said oligonucleotide comprises at least 2 of each of said first and second segments thereby comprising at least 4 alternating segments wherein the number of residues within each first segments and each second segments may be the same or variable from one segment to another, at least one first segment comprises at least two arabinonucleotides and at least one second segment comprises at least two 2′-deoxyribonucleotides, and all internucleotide linkages of the oligonucleotide consist of phosphorothioate linkages.