Patent ID: 7649005

Claim:
A compound according to formula I: wherein, X is oxygen, sulphur or a NR 7 group; R 1 is C 3 -C 8 alkyl or C 1 -C 8 alkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one or more fluoro, chloro, trifluotomethyl, C 1 -C 6 alkyl, hydroxyl, or C 1 -C 6 alkoxy; R 2 and R 3 are independently hydrogen, C 1 -C 6 alkyl, halogen, trifluoromethyl, hydroxy or C 1 -C 6 alkoxy; R 4 is hydrogen or C 1 -C 8 alkyl; R 5 and R 6 are independently hydrogen or C 1 -C 3 alkyl, optionally substituted by hydroxy or phenyl; R 7 is hydrogen or straight or branched C 1 -C 3 alkyl; Het is a five to seven membered, saturated or unsaturated, heteromonocyclic or an eight to ten membered, saturated or unsaturated, heterobicyclic group, containing one or more heteroatoms chosen independently from nitrogen, oxygen and sulphur, said monocyclic or bicyclic groups being optionally substituted by C 1 -C 6 alkyl, halogen, hydroxyl or C 1 -C 6 alkoxy; or the pharmaceutically acceptable salt thereof, with the proviso that: Het cannot be indole, benzo[b]furan, benzo[b]thiophen, chroman, when R 5 and R 6 are both hydrogen, or Het cannot be 2-pyridyl; when R 1 is unsubstituted or substituted benzyl, and R 2 and R 3 are hydrogen, halogen or alkoxy, R 4 is other than hydrogen; when R 1 is propyl or butyl, R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is hydrogen, methyl or ethyl, Het cannot be 1,4-benzodioxan; when X—R 1 is a para butyloxy group and R 2 , R 3 , R 4 , R 5 and R 6 are hydrogen, Het cannot be 2-thiophenyl, or 4-(2,2′-dimethyl)-pyranyl; when X—R 1 is an ortho heptyloxy or octyloxy group and R 2 , R 3 , R 4 , R 5 and R 6 are hydrogen, Het cannot be 2-furyl; and when X—R 1 is an ortho O—(CH 2 ) m -p-CF 3 -phenyl group, where m is an integer from 1 to 3, and R 2 , R 3 , R 5 and R 6 are hydrogen, Het cannot be pyridyl.