Patent ID: 8058305

Claim:
A compound according to the following Formula IV, or a pharmaceutically acceptable salt thereof: wherein A is O, or S; B is (CR 2 R 3 ) n , or absent; or A and B taken in combination form an optionally substituted 1,2-vinylene group or an ethynyl group; V is (CR 2 R 3 ) m , optionally substituted divalent aryl, or optionally substituted divalent heteroaryl; L is C(O)Z; G is oxo (â•O), hydroxyl, or optionally substituted alkoxy; Q is (CR 2 R 3 ) q which may include 0 or 1 carbon-carbon double or triple bonds; U is an optionally substituted alkyl group; Z is hydroxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, amino, NR 4 R 5 , optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, or optionally substituted heteroarylalkyl; n is an integer selected from 0-3; m is an integer selected from 1-6; q is an integer selected from 0-5; R 2 and R 3 are independently selected at each occurrence from the group consisting of hydrogen, hydroxy, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, and optionally substituted heteroalkynyl; and R 4 and R 5 are independently are independently selected at each occurrence from the group consisting of hydrogen optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroaryl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, and optionally substituted heteroarylalkyl, or R 4 and R 5 taken in combination is an optionally substituted heterocycloalkyl.