Patent ID: 6884574

Claim:
A method of detecting or identifying an inhibitor of a mammalian GPR-9-6 comprising: a) combining an agent to be tested, TECK and a cell expressing a protein comprising mammalian GPR-9-6 under conditions suitable for detecting a TECK-induced response, wherein said GPR-9-6 binds TECK, mediates a TECK-induced response and comprises an amino acid sequence that is at least about 90% similar to the amino acid sequence of SEQ ID NO:2; and b) determining the ability of the test agent to inhibit said TECK-induced response, wherein inhibition of said TECK-induced response by the agent is indicative that the agent is an inhibitor, and wherein said TECK-induced response is chemotaxis, Ca 2+ flux, GDP/GTP exchange by GPR-9-6 associated G proteins, cellular proliferation, cellular migration, secretion, exocytosis, degranulation, inflammatory mediator release or respiratory burst.