Patent ID: 7659407

Claim:
A Pyrazole derivative of formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: R is aryl, not substituted or having from one to five substituents, equal to or different from each other, selected from halogen, C 1 -C 7 alkyl, C 1 -C 7 alkylthio, C 1 -C 7 alkoxy, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkoxy, cyano, nitro, amino, N-alkylamino, N,N-dialkylamino, saturated or unsaturated heterocycle, and phenyl; A is an amidic substituent of formula —C(O)—NH-T′, wherein T′ is a group NR 1 R 2 , wherein R 1 and R 2 are equal or different and have the following meanings: C 1 -C 7 alkyl; aryl, arylalkyl or arylalkenyl not substituted or optionally having on the aromatic rings from one to four substituents, equal to or different from each other, selected from halogen, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkoxy, C 1 -C 7 alkylthio, C 1 -C 7 alkoxy, wherein in the previous substituents comprising C 1 -C 7 aliphatic chains, C 1 -C 3 chains are preferably used; wherein R 1 may additionally be hydrogen; or R 1 and R 2 together with the nitrogen atom to which they are linked form a, saturated or unsaturated, heterocycle from 5 to 10 atoms comprising carbon atoms and including the nitrogen of NR 1 R 2 , and optionally an additional S, O or N atom, not substituted or optionally having from one to four substituents, equal to or different from each other, selected from C 1 -C 7 alkyl, phenyl, and benzyl, said phenyl or benzyl optionally substituted with one or more groups, equal to or different from each other, selected from: halogen, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkoxy, C 1 -C 7 alkylthio and C 1 -C 7 alkoxy; B is a group selected from: hydrogen and C 1 -C 4 alkyl; and D is an heteroaryl with a ring size of from 5 to 6 atoms, selected from the group consisting of thiophene, pyridine, furan, oxazole, thiazole, imidazole, pyrazole, isoxazole, isothiazole, triazole, pyridazine, pyrimidine, pyrazine, triazine and pyrrole; wherein the heteroaryl is optionally substituted with one, two, three or four substituents, equal to or different from each other, selected from the following: halogen, C 1 -C 3 alkyl, C 1 -C 3 alkylthio, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, and C 1 -C 3 haloalkoxy.