Patent ID: 7232835

Claim:
A compound having the structure of Formula I: and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantioners, diastereomers, or N-oxides, wherein Ar represents an aryl or a heteroaryl ring having 1–2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from straight or branched lower alkyl (C 1 –C 4 ), trifluoromethyl, methylenedioxy, cyano, hydroxy, halogen (e.g. F, Cl, Br, I), nitro, lower alkoxy (C 1 –C 4 ), aryloxy, amino or lower alkylamino; R 1 represents C 3 –C 9 cycloalkyl ring, a C 3 –C 9 cyclo alkenyl ring, an aryl or a heteroaryl ring having 1 to 2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or a heteroaryl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 –C 4 ), trifluoromethyl, cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 –C 4 ), unsubstituted amino or lower alkyl (C 1 –C 4 ) amino; R 2 represents a hydrogen, hydroxy, amino, alkoxy, alkenyloxy, alkynyloxy, carbamoyl or halogen (e.g. F, Cl, Br, I); W represents (CH 2 ) p , where p represents 0 to 1; X represents an oxygen, sulphur, NR, or no atom, where R is H or lower alkyl (C 1 –C 4 ); Y represents (CHR 5 )q CO wherein R 5 represents hydrogen or methyl; or y represents (CH 2 )q wherein q represents 0 to 4; m represents 0 to 2; R 3 represents hydrogen, lower alkyl or CO 2 C(CH 3 ) 3 ; R 4 represents hydrogen, C 1 –C 15 saturated or unsaturated aliphatic hydrocarbon groups in which any 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen, arylalkyl, arylalkenyl, heteroarylalkyl or heteroarylalkenyl having 1 to 2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulphur atoms with an option that any 1 to 3 hydrogen atoms on an aryl or heteroaryl ring in said arylalkyl, arylalkenyl, hetero arylalkenyl group may be substituted with lower alkyl, trifluoromethyl, cyano, hydroxyl, carboxylic acid, nitro, lower alkoxycarbonyl, halogen, lower alkoxy, amino, lower alkylamino, loweralkyl carbonyl amino, loweralkyl thiocarbonyl amino or loweralkyl carbonyl amino sulphonyl and pharmaceutically acceptable salts thereof.