Patent ID: 6897217

Claim:
A compound having the structural formula or a pharmaceutically acceptable salt thereof, wherein R is R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of H, alkyl and alkoxyalkyl; R 6 is H, alkyl, hydroxyalkyl or —CH 2 F; R 7 , R 8 and R 9 are independently selected from the group consisting of H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo and —CF 3 ; Z is R 10 -aryl, R 10 -heteroaryl or R 10 is 1 to 5 substituents independently selected from the group consisting of hydrogen, alkyl, alkenyl, hydroxy, alkoxy, hydroxyalkyl, hydroxy-alkoxy, alkoxyalkyl, alkoxyalkoxy, alkoxy-alkoxy-alkyl-, (di-alkoxy)-alkyl, (hydroxy)-alkoxyalkyl, R 15 -cycloalkyl, R 15 -cycloalkylalkyl, cycloalkyl-oxy, cycloalkyl-O-alkoxy, alkyl-SO 2 —, alkyl-SO—, halo, —CN, cyanoalkyl, —CHF 2 , —CF 3 , —OCHF 2 , —OCF 3 , —C(O)R 13 , —O-alkylene-C(O)OR 13 , —C(O)O-alkyl, —N(R 11 )(R 12 ), N(R 11 )(R 12 )-alkyl, N(R 11 )(R 12 )-alkoxy, —C(O)N(R 13 )(R 16 ), R 11 -heteroaryl, R 15 -heterocycloalkyl, R 15 -heterocycloalkyl-alkyl, R 15 -heterocycloalkyl-alkoxy, R 15 -heterocycloalkyl-oxy, CF 3 -alkylene-O-alkyl, CF 3 -hydroxyalkyl, (CF 3 )(hydroxy)alkoxy, cyano-alkoxy, -alkylene-C(O)—O-alkyl, —SO 2 —N(alkyl) 2 , (cycloalkyl)hydroxyalkyl, (hydroxyalkyl)alkoxy, (dihydroxy)alkyl, (dihydroxy)alkoxy, —C(═NOR 17 )-alkyl and —C(═NOR 17 )—CF 3 ; or two R 10 groups on adjacent carbon ring atoms together form —O—CH 2 —O—, —O—(CH 2 ) 2 —O—, —CH 2 —O—(CH 2 ) 2 —O—, —O—(CH 2 ) 2 —, —(CH 2 ) 3 —O—, —O—(CH 2 ) 3 —O—, —(CH 2 ) 3 —, wherein the ring formed by the two R 10 substituents and the ring carbon atoms to which they are attached is substituted by R 16 ; or two R 10 groups on adjacent carbon ring atoms together form —N(R 11 )—C(O)—O—, —N(R 11 )—C(O)—S—, —(CH 2 ) 2 CH(OR 18 )—, —CH 2 CH(OR 18 )CH 2 —, —(CH 2 ) 3 CH(OR 18 )—, —(CH 2 ) 2 CH(OR 18 )CH 2 —, —(CH 2 ) 2 C(O)—, —CH 2 C(O)CH 2 —, —(CH 2 ) 3 C(O)—, —(CH 2 ) 2 C(O)CH 2 —, —O(CH 2 ) 2 CH(OR 18 )— or —OCH 2 CH(OR 18 )CH 2 —, wherein the ring formed by two R 10 substituents and the ring carbon atoms to which they are attached is optionally substituted on a carbon atom by hydroxyalkyl or alkoxyalkyl; each R 11 is independently selected from the group consisting of H and alkyl; each R 12 is independently selected from the group consisting of H, alkyl, hydroxyalkyl, alkoxyalkyl, —C(O)-alkyl, —C(O)O-alkyl, (alkoxy)hydroxyalkyl, alkoxyalkyl-C(O)—, —SO 2 alkyl, -alkylene-C(O)alkyl and -alkylene-C(O)O-alkyl; R 13 is H, alkyl or —CF 3 ; R 14 is H, alkyl, alkoxyalkyl, alkyl-C(O)— or alkoxy-C(O)—; R 15 is 1 to 3 substituents independently selected from the group consisting of H, alkyl, —OH, alkoxy, alkoxyalkyl and hydroxyalkyl; or two R 15 substituents, taken together with the carbon to which they are both attached, form a —C(═O)— group; R 16 is H, alkyl, alkoxyalkyl, OH or hydroxyalkyl; R 17 is H or alkyl; and R 18 is H or alkyl.