Patent ID: 8399207

Claim:
A method of determining the presence of C-terminal fragments of osteopontin in a sample suspected of comprising C-terminal fragments of osteopontin, the method comprising: a) providing i) a sample suspected of containing C terminal osteopontin fragments from which full length osteopontin and fragments of osteopontin comprising N-terminal amino acid residues of osteopontin have been removed or separated from any C-terminal fragments present and ii) one or more antibodies specific for epitopes located on the C-terminal of osteopontin selected from the group consisting of 2E11 produced by a hybridoma deposited as ATCC Accession No. PTA-11449 and 1F11 produced by a hybridoma deposited as ATCC Accession No. PTA-11448; b) determining the presence of C-terminal fragments of osteopontin by determining specific binding of fragments in the sample with the one or more antibodies of step a).