Patent ID: 8383188

Claim:
A process for making a suture comprising a jacket comprising a plurality of braided yarns of ultrahigh molecular weight polyethylene coated with arginine-glycine-aspartate (RGD) peptide, comprising the steps of: soaking the suture in a MES buffer; removing the suture from the MES buffer, performing acid hydrolysis on the suture, and subsequently placing the suture back in the MES buffer; removing the suture from the MES buffer and placing the suture into a MES buffer comprising 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysulfosuccinimide (sulfo-NHS); and washing the suture with the MES buffer comprising EDC and sulfo-NHS and immersing the suture into a RGD peptide solution to allow peptides to couple to the suture to form the RGD peptide coated suture.