Patent ID: 8686011

Claim:
A compound represented by the following formula and pharmaceutically acceptable salts, tautomers, optical isomers, and N-oxide forms thereof: wherein X is S; R 5 is selected from C 3-10 -cycloalkyl and C 3-10 -cycloalkyl-C 1-8 -alkyl, wherein any cycloalkyl is optionally independently substituted by one or more C 1-8 -alkyl, aryl, halogen, halo-C 1 -C 8 -alkyl, HOâ€”C 1 -C 8 -alkyl, R 8 R 9 Nâ€”C 1 -C 8 -alkyl, C 1 -C 8 -alkyl-OR 10 , â€”OR 10 , (C 3 -C 10 )-cycloalkyl or C 1 -C 8 -alkyl-sulfonyl; R 6 is unsubstituted C 1-8 -alkyl; wherein R 8 and R 9 are each independently selected from hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, â€”NR 10 R 10 , â€”Sâ€”(C 1 -C 8 )alkyl, aryl and heterocyclyl; wherein any alkyl, alkoxy, heterocyclyl or aryl may be substituted with one to three substituents selected from halo, unsubstituted C 1 -C 8 alkyl, unsubstituted C 1 -C 8 alkoxy, unsubstituted C 1 -C 8 thioalkoxy and unsubstituted aryl(C 1 -C 4 )alkyl; wherein R 10 is independently selected from hydrogen, C 1 -C 8 alkyl, aryl-C 1 -C 8 alkyl, C 1 -C 8 alkoxy, â€”Sâ€”(C 1 -C 8 )alkyl, heterocyclyl and aryl; wherein any alkyl, heterocyclyl or aryl may be substituted with one to three substituents selected from -halo, unsubstituted C 1 -C 8 alkyl, unsubstituted C 1 -C 8 alkoxy, unsubstituted C 1 -C 8 thioalkoxy and unsubstituted aryl(C 1 -C 4 )alkyl.