Patent ID: 8367857

Claim:
A method for producing an isothiocyanate compound comprising at least one carboxyl group and represented by formula (2): (SCN) m -A-B—(CO 2 H) n (2), wherein m, n, A, and B are, respectively, as defined for formula (1), said method comprising reacting an amino compound comprising at least one carboxyl group and represented by formula (1): (H 2 N) m -A-B—(CO 2 H) n (1), wherein: each of m and n, independent of each other, is 1 or 2; A is a C 6-14 aromatic hydrocarbon group or a C 1-12 saturated hydrocarbon group, wherein said C 6-14 aromatic hydrocarbon group and C 1-12 saturated hydrocarbon group are unsubstituted or substituted by at least one selected from the group consisting of a halogen atom, a nitro group, a cyano group, a C 1-6 alkyl group, a hydroxyl group, a protected hydroxyl group, a C 1-6 alkoxy group, a di C 1-6 alkylamino group, a protected amino group, a protected mono C 1-6 alkylamino group, a carboxyl group, a C 1-6 alkylcarbonyl group, and a C 1-6 alkoxycarbonyl group, and at least one methylene group in said C 1-12 saturated hydrocarbon group may be replaced by an oxygen atom, a nitrogen atom substituted by a C 1-6 alkyl group, or a protected nitrogen atom; and B is a single bond, a second C 6-14 aromatic hydrocarbon group, or a second C 1-12 saturated hydrocarbon group, wherein said second C 6-14 aromatic hydrocarbon group and second C 1-12 saturated hydrocarbon group are unsubstituted or substituted by at least one selected from the group consisting of a halogen atom, a nitro group, a cyano group, a C 1-6 alkyl group, a hydroxyl group, a protected hydroxyl group, a C 1-6 alkoxy group, a di C 1-6 alkylamino group, a protected amino group, a protected mono C 1-6 alkylamino group, a C 1-6 alkylcarbonyl group, and a C 1-6 alkoxycarbonyl group, and at least one methylene group in said second C 1-12 saturated hydrocarbon group may be replaced by an oxygen atom, a nitrogen atom substituted by a C 1-6 alkyl group, or a protected nitrogen atom, in a solvent, with carbon disulfide (CS 2 ); and then further reacting with a halogen as a simple substance.