Patent ID: 7041812

Claim:
A composition comprising a terminal phosphate labeled nucleoside polyphosphate of formula wherein P=phosphate (PO 3 ) and derivatives thereof, n is 3 or greater; Y is an oxygen or sulfur atom; B is a nitrogen-containing heterocyclic base; S is an acyclic moiety, a carbocyclic moiety, or sugar moiety; L is a fluorescent, a fluorogenic, a chemiluminescent, a colored, a chromogenic, a mass tag, or an electrochemical label with or without a linker containing a hydroxyl group, a sulfhydryl group, an amino group or a haloalkyl group suitable for forming a phosphate ester, a thioester, a phosphoramidate or an alkyl phosphonate linkage at the terminal phosphate of a natural or modified nucleotide.