Patent ID: 8143236

Claim:
A method for mitigating or alleviating intermittent and cumulative neuropathy in a subject, wherein said method is comprised of a Formula (I) Compound which is administered to the subject in a medically sufficient dosage; and wherein said Formula (I) compound has the structural formula: X—S—S—R 1 —R 2 ; wherein; R 1 is a lower alkylene, wherein R 1 is optionally substituted by a member of the group consisting of: lower alkyl, aryl, hydroxy, alkoxy, aryloxy, mercapto, arylthio, for a corresponding hydrogen atom, or R 2 and R 4 is sulfonate or phosphonate; R 5 is hydrogen, hydroxy, or sulfhydryl; m is 0, 1, 2, 3, 4, 5, or 6; and X is a sulfur-containing amino acid or a peptide consisting of from 2-10 amino acids; or wherein X is a member of the group consisting of: lower thioalkyl (lower mercapto alkyl), lower alkylsulfonate, lower alkylphosphonate, lower alkylsulfonate, lower alkyl, lower alkenyl, lower alkynyl, aryl, alkoxy, aryloxy, mercapto, alkylthio or hydroxy for a corresponding hydrogen atom; and pharmaceutically acceptable salts, conjugates, hydrates, solvates and polymorphs thereof.