Patent ID: 7709488

Claim:
A method for inhibiting inducible NO-synthase activity in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula I in which R1 is hydrogen or 1-4C-alkyl, R2 is hydrogen or 1-4C-alkyl, and R3 is 1-4C-alkyl, trifluoromethyl, or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 is 3-7C-cycloalkyl, phenyl-1-4C-alkyl, hydroxy-2-4C-alkyl, 1-4C-alkoxy-2-4C-alkyl, phenyl, pyridyl, or R11- and/or R12-substituted phenyl, in which R11 is 1-4C-alkyl, halogen, 1-4C-alkoxy, or mono- or di-1-4C-alkylamino, R12 is 1-4C-alkyl or halogen, R2 is hydrogen, hydroxy-2-4C-alkyl, 1-4C-alkoxy-2-4C-alkyl or 1-4C-alkyl, and R3 is hydrogen, halogen, 1-4C-alkoxy, 1-4C-alkyl, trifluoromethyl, or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together and with inclusion of the nitrogen atom, to which they are bonded, form a heterocyclic ring Het, in which Het is a fully saturated or partially unsaturated mono- or fused bicyclic ring or ring system made up of a first constituent being a 3- to 7-membered monocyclic fully saturated non-aromatic heterocyclic ring B, Which heterocyclic ring B comprises one to three heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur, and which heterocyclic ring B is optionally substituted by one or two oxo groups, and, optionally, fused to said first constituent, a second constituent being a benzene ring, and which ring Het is optionally substituted by R21 on a ring carbon atom, and/or which ring Het is optionally substituted by R22 on a further ring carbon atom, and/or which ring Het is optionally substituted by an ethylenedioxy group, and/or which ring Het is optionally substituted by R23 on a ring nitrogen atom, in which R21 is 1-4C-alkyl, 1-4C-alkoxy or phenylcarbonyl, R22 is 1-4C-alkyl or 1-4C-alkoxy, R23 is 1-4C-alkyl, phenyl-1-4C-alkyl, 1-4C-alkylcarbonyl, 1-4C-alkoxy-2-4C-alkyl, mono- or di-1-4C-alkylamino-2-4C-alkyl, phenyl, pyrimidyl, pyridyl, formyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, or R231- and/or R232-substituted phenyl, in which R231 is halogen, cyano or 1-4C-alkyl, R232 is halogen or 1-4C-alkyl, and R3 is hydrogen, halogen, 1-4C-alkoxy, 1-4C-alkyl, trifluoromethyl, or completely or predominantly fluorine-substituted 1-4C-alkoxy, and in which R4 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R5 is 1-4C-alkyl, A is 1-4C-alkylene, or a salt, N-oxide or a salt of an N-oxide thereof.