Patent ID: 8518983

Claim:
A compound of the Formula: wherein: R 1 is H, PO 3 H 2 , SO 3 H 2 , alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n —Ar 1 , wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n —Ar 1 may be substituted or unsubstituted; Z is alkylene of from 1 to 4 carbons, or alkenylene or alkynylene each of from 2 to 4 carbons, wherein said alkylene, alkenylene, or alkynylene may be substituted or unsubstituted; Ar 1 is aryl which may be optionally substituted by one or more substituents selected from halo, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, Z n —OR 1a , Z n —NO 2 , Z n —CN, Z n —(C═O)R 1a , Z n —O(C═O)R 1a , Z n —O-alkyl, Z n —OAr, Z n —SH, Z n —SR 1a , Z n —SOR 1a , Z n —SO 2 R 1a , Z n —S—Ar Z n —SOAr, Z n —SO 2 Ar, aryl, heteroaryl, Z n —Ar, Z n —(C═O)NR 2a R 3a , Z n —NR 2a R 3a , Z n —NR 1a (C═O)R 1a , Z n —SO 2 NR 2a R 3a , PO 3 H 2 , and SO 3 H 2 ; R 1a , R 2a , and R 3a are alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, or Z n -heterocycloalkyl, and Ar is aryl or heteroaryl, A is OH, an amine protecting group, Z n —NR 2 R 3 , Z n —NR 2 (C═O)R 2 , Z n —SO 2 R 2 , Z n —SOR 2 , Z n —SR 2 , Z n —OR 2 , Z n —(C═O)R 2 , Z n —(C═O)OR 2 , Z n —O—(C═O)R 2 , alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n —Ar 1 , wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n —Ar 1 may be substituted or unsubstituted; R 2 and R 3 are independently H, OH, an amine protecting group, an alcohol protecting group, an acid protecting group, a sulfur protecting group, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n —Ar 1 , wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n —Ar 1 may be substituted or unsubstituted, or R 2 together with R 3 and N forms a saturated or partially unsaturated heterocycle ring having 1 or more heteroatoms in said ring, wherein said heterocycle may be substituted or unsubstituted and wherein said heterocycle may be fused to an aromatic ring; B is H, NH 2 , or substituted or unsubstituted methyl; E is H; and n is 0 or 1, or a resolved enantiomer, diastereomer or pharmaceutically acceptable salt thereof.