Patent ID: 7256193

Claim:
A method for treating pain in an animal, comprising administering to an animal in need thereof an effective amount of the compound or a pharmaceutically acceptable salt of the compound of formula: wherein: X is O or S; z is 0 or 1; when z is 0, R 1 is —CH 3 or -halo; when z is 1, R 1 is —H, -halo, —(C 1 -C 6 )alkyl, —NO 2 , —CN, —OH, —OCH 3 , —C(halo) 3 , —CH(halo) 2 , or —CH 2 (halo); R 2 is: (a) —(C 2 -C 6 )alkyl, —(C 2 -C 3 )alkenyl, —(CH 2 ) n C(O)R 6 , —(CH 2 ) n OR 6 , —(CH 2 ) n SR 6 , which is unsubstituted or substituted with one or more of —CN, —OH, -halo, —NO 2 , —CH═NR 6 , or —NR 6 OH; (b) —CH 3 , —CH 2 F, or —CHF 2 , which is unsubstituted or substituted with one or more of —CN, —OH, —Cl, —Br, —I, —NO 2 , —CH═NR 6 , or —NR 6 OH; or (c) —H, -halo, —NO 2 , —CN, or —NH 2 ; R 3 is: (a) —(C 1 -C 6 )alkyl, —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, —(CH 2 ) n OR 6 , which is unsubstituted or substituted with one or more of —CN, —OH, -halo, —NO 2 , —CH═NR 6 , or —NR 6 OH; or (b) —H, -halo, —NO 2 , —CN, or —NH 2 ; R 4 is —H; Ar is —(C 6 )aryl, —(C 10 )aryl, —(C 14 )aryl, —(C 3 -C 8 )cycloalkyl or —(C 5 -C 8 )cycloalkenyl, which is unsubstituted or substituted with one or more R 7 groups; each R 5 is independently —(C 1 -C 6 )alkyl, —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, —(CH 2 ) n (C 3 -C 8 )cycloalkyl, —(CH 2 ) n (C 5 -C 8 )cycloalkenyl, —(CH 2 ) n (C 6 )aryl, —(CH 2 ) n SR 6 , —(CH 2 ) n CH(halo) 2 , —(CH 2 ) n C(halo) 3 , -halo, or —(CH 2 ) n OR 6 ; each R 6 is independently —(C 1 -C 6 )alkyl, —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, or -aryl; each R 7 is independently —(C 1 -C 6 )alkyl, —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, —(CH 2 ) n (C 3 -C 8 )cycloalkyl, —(CH 2 ) n (C 5 -C 8 )cycloalkenyl, —(CH 2 ) n (C 6 )aryl, —(CH 2 ) n SR 6 , —(CH 2 ) n CH(halo) 2 , —(CH 2 ) n C(halo) 3 , -halo, or —(CH 2 ) n OR 6 ; n is an integer ranging from 0 to 2; and p is an integer ranging from 0 to 2.