Patent ID: 7049330

Claim:
A compound having a formula I wherein: X is selected from the group consisting of: n is selected from the integers 1 through 5; R 1 is C 6 –C 10 -aryl or mono or bicyclic heteroaryl having 5–10 atoms, 1 to 3 of which are heteroatoms selected independently from N, S or O, wherein the aryl or heteroaryl group is optionally substituted by F, Cl, Br, I, —OH, —NH 2 , CO 2 H, —CO 2 —C 1 –C 6 alkyl, —CN, —NO 2 , C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 perhaloalkyl, OR 4 , or C 1 –C 6 perhaloalkoxy, with a proviso that heteroaryl is not thiadiazole; R 2 is selected from the group consisting of H and C 1 –C 6 alkyl; R 3 is selected from the group consisting of COR 5 , COOR 5 , and CONR 5 R 6 ; R 4 is H, C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 6 –C 10 aryl or mono or bicyclic heteroaryl as defined above, C 7 –C 14 aralkyl, or mono or bicyclic heteroaralkyl, where the aryl or heteroaryl portion of the araalkyl or heteroaralkyl group is as defined above, and where the aryl, heteroaryl, aralkyl or heteroaralkyl group is optionally substituted with one to three substituents independently selected from the group consisting of F, Cl, Br, I, CN, —NH 2 , —NO 2 , —OH, alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 1 –C 6 perhaloalkyl, C 1 –C 6 alkoxy, and C 1 –C 6 perhaloalkoxy; R 5 and R 6 are selected independently from the group consisting of H, C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 6 cycloalkyl, C 3 –C 6 cycloalkenyl, adamantyl and noradamantyl, or R 5 and R 6 taken together with the interposed nitrogen atom may form a 5–7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR 4 ; wherein when R 5 or R 6 are chosen from C 3 –C 6 cycloalkyl or C 3 –C 6 cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C 1 –C 3 alkyl group; or an optical isomer thereof, a pharmaceutically acceptable salt thereof, or both.