Patent ID: 6903104

Claim:
A compound of formula 1: wherein, R 1 is isoxazolyl, thiazolyl, isothiazolyl, 1,3,4-thiadiazolyl, 1,3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R 5 ; R 2 is H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R 5 ; R 3 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R 5 ; each R 4 is independently H, NO 2 , halo, CN, R 7 , OR 7 , CO 2 R 7 , SR 7 , NR 7 R 7 , C(O)R 7 , C(O)NR 7 R 7 , OC(O)R 7 , S(O) 2 R 7 , S(O) 2 NR 7 R 7 , NR 7 C(O)NR 7 R 7 , NR 7 C(O)R 7 , NR 7 (COOR 7 ), NR 7 S(O) 2 NR 7 R 7 , NR 7 S(O) 2 R 7 , or S(O) 2 OR 7 ; each n is 0, 1, 2, 3, or 4; each R 5 is independently H, C1-C10 alkyl optionally substituted with 1-4 independent R 6 , C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, aryl optionally substituted with 1-4 independent R 6 , heteroaryl optionally substituted with 1-4 independent R 6 , heterocyclyl optionally substituted with 1-4 independent R 6 , halo, haloalkyl, SR 7 , OR 7 , NR 7 R 7 , COOR 7 , NO 2 , CN, C(O)R 7 , C(O)NR 7 R 7 , OC(O)R 7 , S(O) 2 R 7 , S(O) 2 OR 7 , S(O) 2 NR 7 R 7 , NR 7 C(O)NR 7 R 7 , NR 7 C(O)R 7 , NR 7 (COOR 7 ), NR 7 S(O) 2 NR 7 R 7 , or NR 7 S(O) 2 R 7 ; each R 6 is independently C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, halo, haloalkyl, CN, NO 2 , OR 7 , or SO 2 R 7 ; each R 7 is independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted with 1-4 independent R 8 ; each R 8 is independently H, OH, OR 9 , C1-C10 alkyl, halo, aryl, NO 2 , or CN; and each R 9 is independently H, C1-C10 alkyl, or aryl; each being optionally substituted with 1-4 independent OH, halo, CN, NO 2 , or CO 2 H.