Patent ID: 7271271

Claim:
A compound of the formula (I): or a pharmaceutically acceptable salt or prodrug thereof, wherein Q is a member selected from the group consisting of —C(O)—, —CH 2 CO—, —CH 2 SO— and —CH 2 SO 2 —; L is a bond or (C 1 -C 5 )alkylene; R 0 is hydrogen, halogen, unsubstituted or substituted (C 1 -C 8 )alkyl, unsubstituted or substituted (C 1 -C 8 )heteroalkyl, fluoro (C 1 -C 4 )alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted aryl(C 1 -C 8 )alkyl or unsubstituted or substituted heteroaryl(C 1 -C 8 )alkyl, or optionally, R 0 groups on adjacent carbon atoms may be combined to form an unsubstituted or substituted 5- or 6-membered fused ring; the subscript n is 0, 1 or 2; R 1 is unsubstituted or substituted heteroaryl, or unsubstituted or substituted aryl; R 2 is hydrogen, halogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )heteroalkyl, hetero(C 1 -C 10 ) cycloalkyl, (C 1 -C 10 )alkylaryl, or (C 2 -C 10 )heteroalkylaryl; R 3 is a member selected from the group consisting of —S(O) m R 5 , —S(O) m N(R 8 )R 9 , —S(O) m N(R 8 )CH 2 R 6 , —N(R 8 )SO 2 R 5 , —N(R 8 )CH 2 R 10 , wherein R 5 is selected from the group consisting of(C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, aryl and heteroaryl; R 6 and R 7 independently are hydrogen, (C 1 -C 8 )alkyl or (C 2 —C 8 )heteroalkyl, R 8 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, heteroaryl or aryl, R 9 is (C 1 -C 8 )alkyl; R 10 is aryl, Z is CH or N, X is a bond, (C 1 -C 6 )alkylene or (C 1 -C 6 )heteroalkylene, Y is (C 1 -C 6 )alkylene; the subscript m is 0, 1 or 2; and R 4 is a member selected from the group consisting of(C 1 -C 20 )alkyl, (C 2 -C 20 )heteroalkyl, heteroaryl, aryl, heteroaryl(C 1 -C 6 )alkyl, heteroaryl(C 2 -C 6 )heteroalkyl, aryl(C 1 -C 6 )alkyl and aryl(C 2 -C 6 )heteroalkyl.