Patent ID: 7253164

Claim:
A compound of Formula I: in which: n is 1, 2 or 3; Z is selected from —S—, —S(O)—, and —S(O) 2 —; R 1 is selected from hydrogen, C 1-6 alkyl, —XC(O)NR 5 OR 6 , —XNR 5 COR 6 and —XC(O)NR 5 R 6 ; wherein X is selected from a bond, C 1-6 alkylene, C 2-6 alkenylene and C 2-6 alkynylene; wherein X can be optionally substituted with halo, hydroxy and cyano; R 5 is selected from hydrogen, hydroxy and C 1-4 alkyl; and R 6 is selected from hydrogen and C 1-4 alkyl; R 2 is selected from hydrogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, halo-substituted-C 1-12 alkyl, —XOR 5 , —XOR 7 , —XC(O)OR 5 , —XOC(O)R 5 , —XC(O)NR 5 R 6 , —XC(O)NR 5 R 7 , —XC(O)NR 5 OR 6 , —XR 7 , —XCHR 7 R 7 , —XC(O)R 6 , —XOXOR 6 , —XOXOR 7 , —XC(O)R 7 , —XC≡N, —XC(O)XR 7 , —XOXR 7 , —XC(O)NR 5 XR 7 and —XC(O)NR 5 XNR 5 R 6 ; wherein X, R 5 and R 6 are as described above and R 7 is selected from C 3-10 cycloalkyl, C 5-8 heterocycloalkyl, C 6-10 aryl and C 5-8 heteroaryl; wherein any cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 7 can be optionally substituted by one to three radicals selected from halo, C 1-4 alkyl, C 1-4 alkoxy, cyano, halo-substituted-C 1-4 alkyl and —XC(O)OR 5 ; wherein X and R 5 are as described above; with the proviso that R 1 and R 2 cannot both be hydrogen; with the proviso that R 2 is not hydrogen when R 1 is —CH 2 C(O)NHOH; R 3 is selected from hydrogen, halo, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof.