Patent ID: 7169817

Claim:
A compound of formula I wherein Y is —CH 2 CH 2 —, —CH 2 CH(OH)—, —CH(OH)CH 2 —, —C(O)CH 2 —, —CH 2 C(O)—, —CH═CH—; or 1,2-cyclopropylene; X is phenylene optionally substituted by one to three substituents selected from halogen, nitro, C 1-10 alkyl and halogen-substituted C 1-6 alkyl; R 1 is phenyl or phenyl-C 2-4 alkenyl, each being substituted by (i) one to three substituents selected from hydrogen, halogen, amino, phenyl, heteroaryl, heteroaryl-C 1-4 alkyl, C 1-10 alkyl, cycloalkyl-C 1-4 alkyl, cycloalkyl-C 1-4 alkoxy, C 1-10 alkoxy, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkylthio, C 1-10 alkylsulfonyl, C 1-10 alkylsulfinyl, C 1-4 alkyl-S(O) 2 NH—, phenylC 1-6 alkyl, or phenylC 1-6 alkoxy, in each of which any aliphatic part of the group may be straight or branched chain and optionally substituted by up to three substituents selected from halogen, amino, hydroxy, cyano, or cycloalkyl groups and optionally interrupted by a double or triple bond or one or more C(O), NR 12 , S, S(O), S(O) 2 or O groups, wherein R 12 is hydrogen or C 1-6 alkyl; and any aromatic group may be optionally substituted by one to three substituents selected from halogen, cyano, amino, C 1-4 alkyl halogen-substituted-C 1-4 alkyl and C 1-8 alkoxy; and/or (ii) a group of formula (a): in which R 6 and R 7 , independently, is hydrogen; phenyl, C 1-10 alkyl, cycloalkyl, heteroaryl, heteroaryl-C 1-4 alkyl, C 1-10 alkoxy, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkylthio, C 1-10 alkylsulfonyl, C 1-10 alkylsulfinyl, phenylC 1-8 alkyl, or phenylC 1-6 alkoxy, in each of which any aliphatic part of the group may be straight chain or branched and may be optionally substituted by up to three halogen, hydroxy, cycloalkyl, or C 1-4 alkoxy groups and optionally interrupted by a double or triple bond or one or more C(O), NR 12 , S, S(O), S(O) 2 or O groups, and any aromatic group may be optionally substituted by one to three substituents selected from halogen, CF 3 , C 1-8 alkyl and C 1-8 alkoxy; R 2 is hydrogen; halogen; C 1-4 alkyl optionally substituted with one or more halogens; C 2-6 alkenyl; C 2-6 alkynyl; or cycloalkyl optionally substituted by halogen; aryl optionally substituted with hydroxy; or C 1-4 alkyl optionally substituted on the terminal C atom by OH or a residue of formula (h): in which Z is a direct bond, O, S, (CH 2 ) 1-2 , CF 2 , or NR 11 where R 11 is H, (C 1-4 )alkyl or halogen-substituted (C 1-4 )alkyl; and each of R 9 and R 10 , independently, is H, OH, (C 1-4 )alkyl optionally substituted by one to three halogens, or (C 1-4 )alkoxy optionally substituted by halogen; with the proviso that R 9 and R 10 are not both hydrogen; each of R 3 and R 4 , independently, is H or C 1-4 alkyl optionally substituted by halogen or acyl; and R 5 is H, —OH, —Oacyl, —NHacyl, or a residue of formula (h) as defined above; provided that at least either R 2 comprises a terminal OH or a residue of formula (h) or R 5 is OH or a residue of formula (h), or a salt thereof.