Patent ID: 8349836

Claim:
A compound of formula I: wherein R 1 and R 2 are each independently hydrogen, carboxyl, alkyl, alkenyl, alkynyl, aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, alkylheterocyclyl, acyl, alkoxy, alkythio, arylthio, or alkoxycarbonyl, wherein, if present, the aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, or alkylheterocyclyl may be substituted, in one or more positions with a substituent selected from halogen, hydroxy, cyano, nitro, amino, carboxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino or alkylthio; R 3 is hydrogen, halogen, hydroxy, cyano, amino, carboxyl, alkyl, alkenyl, alkynyl, aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, alkylheterocyclyl, acyl, alkoxy, alkythio, arylthio, -alkylene-NR a R b , —C(O)R a , —C(O)NR a R b , —C(O)OR a , —C(S)NR a R b , —C(S)R a , —C(O)SR a , NO 2 , NH 2 , —NR a (O)R b , —NR a R b , —NR a OR b , —NR a C(S)R b , —NR a C(O)NR b R c , —NR a C(S)NR b R c , —NR a (COOR b ), —NR a S(O) 2 NR b R c , —NR a S(O)R b , —NR a S(O) 2 R b , —OR a , —OC(O)R a , —ONR a R b , —OC(O)NR a R b , —SR a , —S(O) 2 R a , or —S(O) 2 NR a R b , wherein R a , R b and R c are each independently hydrogen, halogen, hydroxy, cyano, nitro, amino, carboxyl, alkyl, alkenyl, alkynyl, aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, alkylheterocyclyl, acyl, alkoxy, alkythio, arylthio, or alkoxycarbonyl, wherein, if present, the aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, or alkylheterocyclyl may be substituted, in one or more positions with a substituent selected from halogen, hydroxy, cyano, nitro, amino, carboxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino or alkylthio; and R 4 and R 5 are each independently hydrogen, carboxyl, alkyl, alkenyl, alkynyl, aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, alkylheterocyclyl, acyl, alkoxy, alkythio, arylthio, or alkoxycarbonyl, wherein, if present, the aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, heterocyclyl, or alkylheterocycle may be substituted, in one or more positions with a substituent selected from halogen, hydroxy, cyano, nitro, amino, carboxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, alkylthio, —C(O)NR d -alkylheterocyclyl (in which R d is H or alkyl), or O-alkylheterocycle, and pharmaceutically acceptable salts thereof, provided that when R 3 is heterocyclyl, said heterocycle is other than 4-hydroxy-1-piperidinyl.