Patent ID: 7659294

Claim:
A compound represented by Formula I or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1, or 2; m is 0, 1, or 2, such that when m is 0 then A is bonded directly to the azetidine (n=0), pyrrolidine (n=1), or piperidine (n=2) group shown in Formula I; R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of: —H, —F, C 1 -C 4 alkyl, C 1 -C 4 perfluoroalkyl, —Cl, —Br, C 1 -C 8 alkoxy, and —OCF 3 ; R 5 and R 6 are independently selected from: —H, —OH, —F, C 1 -C 4 alkyl, and C 1 -C 4 perfluoroalkyl; R 7 is selected from the group consisting of: phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridizinyl and thienyl, each optionally substituted with one to three substituents independently selected from the group consisting of: —F, —Cl, —Br, —I, —CN, —OH, —NR 8 R 9 , —NO 2 , phenyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkoxy, C 1 -C 6 alkylthio and C 2 -C 6 acyloxy, wherein said phenyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkoxy, C 1 -C 6 alkylthio and C 1 -C 6 acyloxy are each optionally substituted with one to three substituents independently selected from the group consisting of: —F, —Cl, —Br, —I, —OH and C 1 -C 5 alkoxy; R 8 and R 9 are independently selected from the group consisting of: C 1 -C 6 alkyl, C 1 -C 6 alkenyl and C 1 -C 6 alkynyl, each optionally substituted with one to three substituents independently selected from the group consisting of: —F, —Cl, —Br, —I, —OH and C 1 -C 5 alkoxy, or R 8 and R 9 may be joined together with the nitrogen atom to which they are attached to form a saturated monocyclic ring of 3 to 8 atoms, optionally containing 1 or 2 oxygen atoms, said ring is optionally substituted with one to three substituents independently selected from the group consisting of: —F, —Cl, —Br, —I, —OH and C 1-5 alkoxy; X, Y, and Z are independently selected from the group consisting of: —C═, —CH—, —O—, —N═, —NH—, —N(R 10 )— and —S— such that the resulting ring is an aromatic heterocycle; R 10 is selected from the group consisting of: C 1 -C 6 alkyl, C 1 -C 6 alkenyl and C 1 -C 6 alkynyl, each optionally substituted with one to three substituents independently selected from the group consisting of: —F, —Cl, —Br, —I, —OH and C 1 -C 5 alkoxy; A is selected from the group consisting of: —CO 2 H, —PO 3 H 2 , —PO 2 H 2 , —SO 3 H, —CONHSO 2 R 11 , —PO(R 11 )OH, R 11 is selected from the group consisting of: C 1 -C 4 alkyl, phenyl, —CH 2 OH and CH(OH)-phenyl; and each R 12 is independently selected from the group consisting of: —H and —CH 3 .