Patent ID: 8193214

Claim:
A compound of the formula (I): R1 and R2 are independently hydrogen, halogen, trihaloalkyl, trihaloalkoxy, cyano, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, —CORd, —COORd, —CON(Rc)Rd, —N(Rc)Rd, —N(Rc)CORd wherein each Rd is independently a hydrogen, C 1-6 linear or branched alkyl or cycloalkyl, C 1-6 linear or branched alkenyl or heterocyclyl or where R1 and R2 together represent —O—CH 2 —O, —O—CH 2 —CH 2 —O— or —CH 2 —CH 2 —CH 2 —, wherein each group is optionally independently substituted with one to three substituents chosen from C 1-4 acyl, C 1-4 alkyl, C 1-4 alkoxy, amino, dialkylamino, cyano, carboxy, carboxamido, halogen, hydroxyl and phenyl optionally substituted with halogens; A is C 1 -C 7 linear, branched or cyclic alkyl group optionally interrupted by one or more —O—, —S—, —SO—, and —SO 2 — optionally substituted with one to three substituents chosen from halogen, C 1-6 linear or branched alkyl, C 1-6 linear or branched alkoxy, C 1-6 linear or branched alkylthio, C 1-6 linear or branched alkylsulfonyl, phenyl and oxo; E is —COORe, —SO 3 Re, —CONHRe, —SO 2 NHRe, —NHSO 2 Re, —CONHSO 2 Re, —SO 2 NH—CO(Rf), heteroaryl, heterocycyl, wherein each Re is independently hydrogen, C 1-4 alkyl or aryl, and Rf is C 1-4 alkyl or aryl; G is C 1-6 linear or branched alkyl optionally interrupted by one or more of —O—, —S—, —SO 2 or —NRa—, wherein the alkyl group is optionally substituted with hydroxyl, cyano, C 1-6 linear or branched alkyl or C 1-6 linear or branched alkoxy; M is a methylene group, oxygen, or —S(O) m —, where m is an integer of 0-2; and, wherein the said methylene group is optionally substituted by one to two substituents chosen from hydroxyl, cyano, C 1-6 linear or branched alkyl, C 1-6 linear or branched alkoxy, trihalomethyl, trihalomethoxy, phenyl and oxo; J is an optionally mono- or poly-substituted aromatic carbocycle or a heteroaromatic group having 4-10 carbon atoms containing one or more hetero atoms chosen from the group consisting of an oxygen atom, a nitrogen atom and a sulfur atom in its ring(s); each substituent on said aromatic or heteroaromatic groups is chosen from halogen, hydroxyl, cyano, C 1-6 linear or branched alkyl, C 1-6 linear or branched alkoxy, C 1-6 linear or branched alkylthio, C 1-6 linear or branched alkylsulfonyl, phenylsulfonyl, C 1-6 linear or branched acyl, C 1-6 linear or branched acylamino, trihalomethyl, trihalomethoxy, phenyl, oxo, —COORa, —CON(Rc)Ra, SO 2 N(Rc)Ra, —N(Rc)Ra and phenoxy optionally substituted by one or more halogens; Ra, and Rc are each independently C1-3 alkyl or hydrogen; or the pharmaceutically acceptable salts thereof.