Patent ID: 8512710

Claim:
A fusion protein, comprising at least one catalytic domain of a sialidase and at least one anchoring domain, wherein the catalytic domain sequence comprises: a) the sequence of amino acids extending from amino acid 274 to amino acid 681 of SEQ ID NO:12, inclusive and lacks the sequence that consists of the sequence extending from amino acid 1 to amino acid 273 and from amino acid 682 to amino acid 901 of SEQ ID NO:12; b) the sequence of amino acids extending from amino acid 290 to amino acid 666 of SEQ ID NO:12, inclusive and lacks the sequence that consists of the sequence extending from amino acid 1 to amino acid 289 and from amino acid 667 to amino acid 901 of SEQ ID NO:12; or c) the sequence of amino acids extending from amino acid 290 to amino acid 681 of SEQ ID NO:12, inclusive and lacks the sequence that consists of the sequence extending from amino acid 1 to amino acid 289 and from amino acid 682 to amino acid 901 of SEQ ID NO:12; and the anchoring domain comprises the GAG-binding domain of human platelet factor 4 (SEQ ID NO:2), the GAG-binding domain of human interleukin 8 (SEQ ID NO:3), the GAG-binding domain of human antithrombin III (SEQ ID NO:4), the GAG-binding domain of human apoprotein E (SEQ ID NO:5), the GAG-binding domain of human angio-associated migratory protein (SEQ ID NO:6), or the GAG-binding domain of human amphiregulin (SEQ ID NO:7).