Patent ID: 7507420

Claim:
A compound having the structure: wherein A is a member selected from substituted or unsubstituted phenyl and substituted or unsubstituted pyrrole; Z is a member selected from O, S and NR 23 ; X is a member selected from O, S and NR 23 wherein each R 23 is independently a member selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and acyl; R 3 is a member selected from the group consisting of (=O), SR 11 , NHR 11 and OR 11 , wherein R 11 is a member selected from the group consisting of H, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, diphosphates, triphosphates, acyl, C(O)R 12 , C(O)OR 12 , C(O)NR 12 R 13 , P(O)(OR 12 ) 2 , C(O)CHR 12 R 13 , SR 12 and SiR 12 R 13 R 14 , in which R 12 , R 13 , and R 14 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl and substituted or unsubstituted aryl, wherein R 12 and R 13 together with the nitrogen or carbon atom to which they are attached are optionally joined to form a substituted or unsubstituted heterocycloalkyl ring system having from 4 to 6 members, optionally containing two or more heteroatoms; R 4 and R 5 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, halogen, NO 2 , NR 15 R 16 , NC(O)R 15 , OC(O)NR 15 R 16 , OC(O)OR 15 , C(O)R 15 , SR 15 , and OR 15 wherein R 15 and R 16 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl and substituted or unsubstituted peptidyl; and R 6 is a single bond which is either present or absent and when present R 6 and R 7 are joined to form a cyclopropyl ring; and R 7 is CH 2 —X 1 or —CH 2 — joined in said cyclopropyl ring with R 6 , wherein X 1 is a leaving group; wherein the compound comprises at least one member selected from R 15 or R 16 having the structure: wherein X 4 is member selected from protected or unprotected reactive functional groups, detectable labels and targeting agents; L 3 is a linker selected from substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl groups; AA 1 , AA C and AA c+1 are members independently selected from natural and unnatural α-amino acids; L 4 is a linker selected from substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl groups, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted cycloalkyl; p and t are integers independently selected from 0 and 1; and c is an integer from 0 to 20; or a pharmaceutically acceptable salt thereof.