Patent ID: 8828413

Claim:
A peptoid oligomer according to formula (Ia) or (Ib): wherein the peptoid oligomer consists of a repeating unit of a monomer wherein each R 1 is independently R 1a , R 1b , or R 1c ; each R 2 is independently hydrogen, or unsubstituted alkyl; or each R 1 and R 2 are joined together to form a 4-7 membered heterocyclic ring; each R 1a is independently Et, n-Pr, i-Pr, n-Bu, sec-Bu, i-Bu, or alkyl substituted with halo, hydroxy, nitro, or alkoxy; each R 1c is independently substituted or unsubstituted aryl, substituted or unsubstituted phenylalkyl, substituted or unsubstituted naphth-2-ylalkyl, substituted or unsubstituted furanyl, substituted or unsubstituted thienyl, or substituted or unsubstituted diarylalkyl; X is H, C(O)R 20 , or C(O)R 21 ; and each R 1b is independently 5-aminopentyl, 6-aminohexyl, guanidinoalkyl (H 2 N—C(═NH)—NH-alkyl), imidazolylmethyl, 2-imidazolylethyl, 4-imidazolylbutyl, 5-imidazolylpentyl, 6-imidazolylhexyl, or alkyl substituted with pyrrolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, thiadiazolyl, triazolyl, or tetrazolyl, and wherein each R 1b is unsubstituted or substituted with one or more F; or X is C(O)R 20 , or C(O)R 21 ; and each R 1b is independently 3-aminopropyl, or 4-aminobutyl; R 20 is unsubstituted C 1 -C 30 alkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkylmethyl, 4-10 membered heterocycloalkyl, aryl, arylalkyl, 5-10 membered heteroaryl or heteroarylalkyl; R 21 is C 1 -C 8 alkyl, C 3 -C 10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6 -C 10 aryl, arylalkyl, 5-10 membered heteroaryl or heteroarylalkyl, wherein the alkyl is substituted with halo or hydroxyl, and wherein the cycloalkyl, the heterocycloalkyl, the aryl, the arylalkyl, the heteroaryl, the heteroarylalkyl are substituted with unsubstituted C 1 -C 4 alkyl, halo, unsubstituted C 1 -C 4 alkoxy, unsubstituted C 1 -C 4 haloalkyl, unsubstituted C 1 -C 4 hydroxyalkyl, unsubstituted C 1 -C 4 haloalkoxy, or hydroxyl; Y is NH 2 , OH, acylamino, or acyloxy; n is an integer between 2 and 20, when the peptoid oligomer is of formula (Ia); and n is an integer between 4 and 20, when the peptoid oligomer is of formula (Ib); provided that: i) at least one instance of R 1 is R 1b ; ii) when the peptoid oligomer is of formula (Ia) and R 1b is 2-imidazol-4-ylethyl, then X is other than H; and iii) when the peptoid oligomer is of formula (Ia), then the oligomer further consists of the terminal groups X and Y; a pharmaceutically acceptable salt, a solvate, a prodrug, stereoisomers, isotopic variants, or tautomers thereof.