Patent ID: 7927799

Claim:
A method for identifying inhibitors of prostaglandin-endoperoxide H synthase-2 (PGHS-2) transactivation activity, the method comprising: a) contacting a nucleic acid probe comprising at least one region of a PGHS-2 promoter with PGHS-2 protein in the presence and absence of a test compound; and b) determining the level of binding of PGHS-2 protein to the probe; wherein the at least one region of the PGHS-2 promoter is selected from the group consisting of a c/EBP site, a CRE site and a NF-kB site, and wherein a decrease in amount of protein bound in the presence of said test compound compared to amount of protein bound in the absence of said test compound indicates that the compound is an inhibitor of PGHS-2 transactivation activity.