Patent ID: 8518943

Claim:
A compound having the form of structural formula (I) or in the form of a geometric isomer, enantiomer, diastereomer, or pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, substituted or unsubstituted C 1-12 alkyl, substituted or unsubstituted aryl or substituted or unsubstituted 3-8 membered heterocycle, R 2 is hydrogen, R 3 is either (a) a substituted or unsubstituted heterocycle linked to the rest of the molecule via one of its C atoms, said heterocycle is selected from the group consisting of: 1H-benzimidazol-6-yl; 1H-benzimidazol-7-yl; imidazo[1,2-a]pyridin-3-yl; imidazo[1,2-a]pyrimidin-3-yl; imidazo[1,2-b][1,2,4]triazin-7-yl; imidazo[1,2-b]pyridazin-3-yl; 5,6,7,8-tetrahydroimidazo[1,2-b]pyridazin-3-yl; imidazo[2,1-b][1,3,4]thiadiazol-5-yl; imidazo[2,1-b][1,3]thiazol-5-yl; 3H-imidazo[4,5-b]pyridin-7-yl; 1H-imidazol-4-yl; 1H-imidazol-5-yl; 1H-indol-2-yl; 1H-indol-3-yl; 1H-indol-4-yl; 1H-indol-7-yl; isoxazol-4-yl; 1H-pyrazol-4-yl; 1H-pyrazol-5-yl; 1H-pyrazolo[1,5-a]pyrimidin-3-yl; 1H-pyrazolo[3,4-b]pyridin-3-yl; pyridazin-4-yl; pyridin-2-yl; pyridin-3-yl; pyridin-4-yl; 1H-pyrrolo[2,3-b]pyridin-3-yl; 1H-pyrrolo[2,3-b]pyridin-4-yl; 1H-pyrrolo[2,3-b]pyridin-5-yl; 1H-pyrrolo[2,3-c]pyridin-2-yl; 1H-pyrrolo[2,3-c]pyridin-3-yl; 1H-pyrrolo[3,2-b]pyridin-3-yl; 1H-pyrrolo[3,2-c]pyridin-2-yl; 1H-pyrrolo[3,2-c]pyridin-3-yl; 1,3,4-thiadiazol-2-yl; 1,3-thiazol-5-yl; [1,2,4]triazolo[4,3-b]pyridazin-7-yl; [1,2,4]triazolo[4,3-b]pyridazin-8-yl; or indolizin-3-yl; or R 3 is (b) a substituted or unsubstituted heterocycle linked to the rest of the molecule via one of its N atoms, said heterocycle is selected from the group consisting of: 1H-1,2,3-benzotriazol-1-yl; 1H-imidazo[4,5-b]pyridin-1-yl; 3H-imidazo[4,5-b]pyridin-3-yl; 7H-imidazo[4,5-c]pyridazin-7-yl; 1H-indol-1-yl; 2,3-dihydro-1H-indol-1yl; 9H-purin-9-yl; 1H-pyrazolo[3,4-b]pyridin-1-yl; 2H-pyrazolo[3,4-b]pyridin-2-yl; 1H-pyrrolo[2,3-b]pyridin-1-yl; 1H-pyrrolo[3,2-b]pyridin-1-yl; 3,4-dihydroquinolin-1(2H)-yl; 8H-isothiazolo[5,4-b]indol-8-yl; 1H-1,2,4-triazol-1-yl; 1H-pyrrol-1-yl; or 2-chloro-1H-benzimidazol-1-yl, R 4 in formula (I) is selected from the group comprising or consisting of C 1-12 alkyl optionally substituted by halogen, C 1-4 alkoxy, C 1-4 alkylthio, azido, nitrooxy or an aryl; C 2-12 alkenyl optionally substituted by halogen; C 2-12 alkynyl optionally substituted by halogen; azido; alkoxycarbonylamino; arylsulfonyloxy; a substituted or unsubstituted aryl; or a 3-8 membered substituted or unsubstituted heterocycle; and R 5 is hydrogen.