Patent ID: 8877778

Claim:
A compound of formula (I) wherein n is 0, 1, 2, 3 or 4; x is a single bond or double bond; Y is —C(O)— or —S(O) 2 —; R 1 hydrogen, cyano, alkyl, haloalkyl, alkenyl, alkynyl, hydroxy, alkoxy, cycloalkyl, heterocycloalkyl, aryl, aryl annelated to heterocycloalkyl, heteroaryl, —NR 7 R 8 , —C(O)—NR 7 R 8 , or —S(O) 2 —R 7 , wherein alkyl, haloalkyl, and alkoxy are each optionally substituted by one to three independent R 5 and wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted by one to three independent R 6 ; R 2 , R 3 , and R 4 are each independently hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy or haloalkoxy; R 5 is cyano, hydroxy, alkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted by one to three independent R 6 ; R 6 is halogen, cyano, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, oxo, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or —S(O) 2 —R 7 , wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted by one to three independent R 9 ; and R 7 , R 8 , and R 9 are each independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, or heteroaryl; or a pharmaceutically acceptable salt or ester thereof.