Patent ID: 7919315

Claim:
A method for stratifying mammalian subjects having at least one cardiovascular disease, comprising: a) isolating, from a biological sample obtained from a mammalian subject having at least one cardiovascular disease, bone marrow-precursor-cells (BMP) and/or blood-derived circulating precursor-cells (BDP) by means of at least one cell specific surface marker; b) performing a cell migration assay on the BMP and/or BDP to provide an assessment of migratory capacity thereof; c) determining, based on the assessed migratory capacity, the cardiovascular functionality of BMP and/or BDP; and d) determining, based on the determined cardiovascular functionality, whether the subject would benefit from cell therapy and/or an ex vivo pretreatment of their BMPs or BDPs before retransplantation of the cells to provide for improvement of subject's cardiovascular functionality, wherein a method for stratifying mammalian subjects having at least one cardiovascular disease is afforded.