Patent ID: 8202688

Claim:
A method for inducing an immune response against hepatitis virus comprising: administering to a subject infected with hepatitis virus, a synthetic oligonucleotide having a sequence including at least the following formula: 5′X 1 X 2 CGX 3 X 4 3′ wherein the oligonucleotide is 8 to 100 nucleotides in length wherein C is unmethylated and wherein X 1 X 2 and X 3 X 4 are nucleotides, wherein the oligonucleotide is SEQ ID NO. 77, in an effective amount to produce an immune response against the hepatitis virus, and further comprising administering an antigen and a non-nucleic acid adjuvant, wherein the oligonucleotide and the non-nucleic acid adjuvant are administered in an amount specific for inducing a synergistic antigen-specific immune response.