Patent ID: 7816089

Claim:
A method for determining whether a subject with neuroblastoma has a stage I, stage II, stage III, or stage IV neuroblastoma, the method comprising: a) obtaining from a subject diagnosed with neuroblastoma a sample comprising neuroblastoma cells from a solid tumor; and b) detecting Id2 protein in intact cells in the sample using an antibody, or Fab or F(ab′) 2 fragment thereof, that is reactive with Id2 protein, wherein a sample with an Id2 labeling index of about 5% of the cells in the sample indicates that the neuroblastoma is a stage I neuroblastoma; wherein a sample with an Id2 labeling index of about 30% of the cells in the sample indicates that the neuroblastoma is a stage II neuroblastoma; wherein a sample with an Id2 labeling index of about 35% of the cells in the sample indicates that the neuroblastoma is a stage III neuroblastoma; and wherein a sample with an Id2 labeling index of about 50% of the cells in the sample indicates that the neuroblastoma is a stage IV neuroblastoma.