Patent ID: 7599800

Claim:
A method for predicting probe hybridization to a DNA chip, comprising: receiving sample genetic information, wild-type probe genetic information, mutant-type probe genetic information, and a mutation position for each type of genetic information from a user of a DNA chip; aligning the sample genetic information, the wild-type probe genetic information, and the mutant-type probe genetic information at the mutation position in each type of genetic information; coding the aligned genetic information by creating first code strings and second code strings, the first code strings being created by assigning first orthogonal codes, sequentially from left to right excluding the mutation position, to bases in the aligned genetic information and adding a flag to the assigned first orthogonal codes that represents the presence or absence of a corresponding base in each type of genetic information, and the second code strings being created by assigning second orthogonal codes to a base located at the mutation position and adding a flag to the assigned second orthogonal codes that represents whether the base located at the mutation position of the sample genetic information is wild-type or mutant-type; inputting the coded aligned genetic information into a neural network trained to predict results of hybridization to the DNA chip; and outputting from the neural network the hybridization intensity ratios between wild-type probes and mutant-type probes, or the transformed values thereof, to the user of the DNA chip.