Patent ID: 7652004

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is furanyl, pyrrolyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, triazolyl, or tetrazolyl, and is substituted with 0-2 substituents selected from oxo, amino, alkylthio, alkyl, and haloalkyl, and 1 substituent selected from CO 2 R 5 , CON(R 12 ) 2 , and COR 13 ; R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 )(R 10 )NSO 2 , or (R 11 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-1 alkyl substituents; R 12 is hydrogen, alkyl, alkoxyalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or (R 11 )alkyl; R 13 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from alkyl, alkoxyalkyl, amino, alkylamino, dialkylamino, R 11 , aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (R 11 )alkyl, or CO 2 R 5 ; or R 13 is or R 13 is or R 13 is a [4.3.0] or [3.3.0] bicyclic diamine attached to the carbonyl through one nitrogen, and is substituted with 0-2 R 8 substituents; or R 13 is R 14 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or benzyl; R 15 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or benzyl; or NR 14 R 15 taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; R 16 is hydrogen or alkyl; R 17 is hydrogen, alkyl, or cycloalkyl; and X is methylene, a bond, or absent; or a pharmaceutically acceptable salt thereof.