Patent ID: 8168792

Claim:
A compound according to formula I: A-R (I) wherein: A is 2 oxo-1,2-dihydro-pyridin-3-yl; R is Ia, Ib or Ic; X is NR 4 or O; X 1 and X 2 together are oxo; R 3a is hydrogen and R 3b is CH 2 Ar or R 3a and R 3b together are ═CHAr; Ar is phenyl optionally independently substituted with one to three substitutents selected from the group consisting of (a) hydroxy, (b) C 1-6 alkoxy, (c) C 1-6 alkyl, (d) C 1-6 hydroxyalkyl, (f) halogen, (h) cyano, (i) CO 2 R 5 , (j) CONR c R d , (k) C 1-3 acylamino, (l) (CH 2 ) n NR a R b , (m) (CH 2 ) n CONR c R d , (n) (CH 2 ) n SO 2 NR c R d , (o) (CH 2 ) n SO 2 R 5 and (p) O(CH 2 ) n CONR c R d ; R a and R b are independently in each occurrence (a) hydrogen, (b) C 1-6 alkyl, (c) C 1-6 acyl, (d) C 1-6 alkylsulfonyl, (e) C 1-6 haloalkylsulfonyl, (f) C 3-7 cycloalkylsulfonyl, (g) C 3-7 cycloalkyl-C 1-3 alkyl-sulfonyl or (h) C 1-6 alkoxy-C 1-6 alkylsulfonyl, (i) SO 2 (CH 2 ) n NR c R d , (j) carbamoyl, (k) C 1-3 alkylcarbamoyl, (l) C 1-3 dialkylcarbamoyl or (m) benzoyl said benzoyl optionally independently substituted with one or two groups selected from the group consisting of amino, halogen, C 1-6 alkyl or C 1-3 alkylsulfonylamino; R c and R d are independently in each occurrence hydrogen, C 1-6 alkyl, C 1-6 acyl, or together with the nitrogen to which they are attached form a cyclic amine; R 1 is hydrogen, C 1-6 alkyloxy or C 1-6 haloalkyloxy or R 1 and R 2a together are CH 2 —O and together with atoms to which they are attached form a 2,3-dihydrobenzofuran; R 6 is hydrogen; R 4 is hydrogen or C 1-6 alkyl; R 5 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-3 alkoxy-C 1-3 alkyl or optionally substituted benzyl; R 2a , R 2b and R 2c each are independently C 1-3 alkyl; n is independently in each occurrence an integer from zero to three; or, a pharmaceutically acceptable salt thereof.