Patent ID: 7635769

Claim:
A single strand oligonucleotide of the formula I 5′-(M)x-(Z)n Formula I where M comprises naturally or not naturally occurring ribonucleotides which are complementary to a target RNA, x is independently 10 to 100, n is 2 to 20, Z comprises naturally or not naturally occurring nucleotides which are linked via a 2′5′ internucleoside bond, with the proviso that its homologous target RNA has one of the following sequence patterns: 5′-(U)v-(N)z-(U)w 5′-(U)v-(N)z-UX 5′-UX-(N)z-UX and 5′-(U)v-(N)z, where v is independently 2 to 20, where w is independently 2 to 20, z is independently 15 to 25, U is uridine, N is adenosine (A), guanosine (G), cytidine (C) or U and X is A, G or C, or physiologically tolerated salts thereof.