Patent ID: 8580525

Claim:
A method for screening for modulators of LTRPC7 (“Long Transient Receptor Potential Channel”), said method comprising: a) contacting a cell comprising LTRPC7 polypeptide with a candidate bioactive agent; and b) determining whether said agent modulates the multivalent cationic permeability of a multivalent cation other than Ca 2+ through LTRPC7 by measuring a change in the intracellular level of said multivalent cation as compared to the multivalent cation permeability in the absence of said candidate agent, wherein said LTRPC7 has an amino acid sequence having at least 95% sequence identity to the sequence of SEQ ID NO:1 and wherein said LTRPC7 is permeable to a multivalent cation in the presence of intracellular ATP concentrations in the 0-4 millimolar range.