Patent ID: 7589101

Claim:
A compound of Formula I: in which: X 1 is selected from CH and N; Y is selected from S and NR 5 ; wherein R 5 is selected from hydrogen and C 1-6 alkyl; Z is selected from C and S(O); R 1 is selected from hydrogen and C 1-6 alkyl; R 2 is selected from C 6-12 aryl and —NR 3 R 4 ; R 3 is selected from hydrogen and C 1-6 alkyl; R 4 is —XR 5 ; wherein X is selected from a bond, C 1-6 alkylene and C 1-10 heterarylene; wherein R 5 is selected from C 6-10 aryl and C 1-10 heteroaryl; wherein said aryl or heteroaryl of R 5 is optionally substituted with 1 to 3 radicals independently selected from C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 3-8 heterocycloalkyl, —C(O)NR 6 R 7 and —NR 6 C(O)R 7 ; wherein R 6 is selected from hydrogen and C 1-6 alkyl; and R 7 is selected from C 6-10 aryl and C 1-10 heteroaryl; wherein said aryl or heteroaryl of R 7 is optionally substituted with 1 to 3 radicals independently selected from —R 8 and —OR 8 ; wherein R 8 is selected from C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 6-12 aryl, C 1-10 heteroaryl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein said aryl, heteroaryl and heterocycloalkyl substituents of R 8 are optionally substituted with C 1-6 alkyl; or R 3 and R 4 , together with the atoms to which R 3 and R 4 are attached, form C 3-8 heterocycloalkyl optionally substituted with —C(O)NR 6 R 9 ; wherein R 6 is selected from hydrogen and C 1-6 alkyl; and R 9 is selected from C 6-10 aryl and C 1-10 heteroaryl; and the pharmaceutically acceptable salts thereof.