Patent ID: 8877765

Claim:
A method of treating a subject suffering from colon cancer, comprising determining that the subject has cancer cells that comprise a wild type p53 gene, and administering to the subject an effective amount of a compound according to Formula I: wherein: R 1 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, or optionally substituted heteroalicyclic; R 2 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted heteroalicyclic; R 3 is, for each occurrence, selected from the group consisting of H, amino, hydroxy, cyano, nitro, carboxylate, carboxamide, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclic aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted mono- or di-alkyl amino, optionally substituted cycloalkyl, optionally substituted heteroalicyclic, optionally substituted aminoalkyl, —OR a , —NR a R b , —S(O) q R a , —C(O)R a ,—OC(O)R a , —NR a C(O)R a —C(S)R a , —OC(S)R a , —SC(S)R a , —NR a C(S)R a , —C(NR a )R a , —OC(NR a )R a , —SC(NR a )R a , —NR a SO 2 R c , —OS(O) 2 R a ; Z is selected from N, O, or S(O) q ; wherein R a is absent if not allowed; R a , for each instance is independently selected from the group consisting of H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl, haloalkyl, hydroxylalkyl, alkylcarbonylalkyl, mercaptoalkyl, aminoalkyl, sulfonylalkyl, sulfonylaryl, or thioalkoxy; R b , for each instance is independently selected from the group consisting of H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted heterocycloalkyl, an optionally substituted araalkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl, haloalkyl, —(CH 2 ) n OR c , —(CH 2 ) n SR c , —(CH 2 ) n NR c R c , hydroxylalkyl, alkylcarbonylalkyl, mercaptoalkyl, aminoalkyl, sulfonylalkyl, sulfonylaryl, or thioalkoxy; R c , for each instance is independently selected from the group consisting of H or an optionally substituted alkyl; n is an integer from 0 to 3; q is an integer from 0 to 2; or a pharmaceutically acceptable salt thereof.