Patent ID: 7309791

Claim:
New 3-phenylpropionic acid derivatives of formula (I): wherein: W represents COOH group or —COO—C 1 –C 4 -alkyl group; Y represents NH, N—C 1 –C 10 -alkyl, O, or S; Z represents NH, N—C 1 –C 10 -alkyl, S, or O; X represents O, S, NH, N—C 1 –C 10 -alkyl, or NSO 2 —C 1 –C 10 -alkyl; R 1 to R 6 each independently represents hydrogen atom or a substituent selected from the group consisting of: C 1 –C 4 -alkyl, C 1 –C 4 -alkoxy, C 3 –C 7 -cycloalkyl, C 3 –C 7 -cycloalkoxy, C 1 –C 4 -thioalkoxy, C 3 –C 7 -cyclothioalkoxy, halogen atom, halogen-substituted C 1 –C 4 -alkyl, halogen-substituted C 3 –C 7 -cycloalkyl, —NO 2 , —CN, —SO 2 —NH 2 , —SO 2 —NH—C 1 –C 4 -alkyl, —SO 2 —N(C 1 –C 4 -alkyl) 2 , —CO—C 1 –C 4 -alkyl, —O—CO—C 1 –C 4 -alkyl, —CO—O—C 1 –C 4 -alkyl, —CO-aryl, —CO—NH 2 , —CO—NH—C 1 –C 4 -alkyl, —CO—N(C 1 –C 4 -alkyl) 2 , and aryl, said aryl being optionally substituted with one or more substituents independently selected from the group consisting of C 1 –C 4 -alkyl, C 1 –C 4 -alkoxy, C 3 –C 7 -cycloalkyl, C 3 –C 7 -cycloalkoxy, C 1 –C 4 -thioalkoxy, C 3 –C 7 -cyclothioalkoxy, halogen atom; halogen-substituted C 1 –C 4 -alkyl, halogen-substituted C 3 –C 7 -cycloalkyl; —NO 2 , —CN, —SO 2 —NH 2 , —SO 2 —NH—C 1 –C 4 -alkyl, —SO 2 —N(C 1 –C 4 -alkyl) 2 , —CO—C 1 –C 4 -alkyl, —O—CO—C 1 –C 4 -alkyl, —CO—O—C 1 –C 4 -alkyl, —CO-aryl, —CO—NH 2 , —CO—NH—C 1 –C 4 -alkyl, and —CO—N(C 1 –C 4 -alkyl) 2 ; A represents heteroaryl or heterocyclyl excluding six or more membered heteroaryl compounds containing at least one N; and n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof.