Patent ID: 8283339

Claim:
A compound having the formula wherein Z is —CY═CH— in the trans (e) configuration; Y is hydrogen or halogen, each R 1 is independently halo, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, —NH 2 , —NH(C 1 -C 6 )alkyl, —N((C 1 -C 6 )alkyl) 2 , or cyano; and R 2 is hydrogen, halo, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkoxyl, (C 3 -C 10 )cycloalkyl, (C 2 -C 12 )alkenyl, (C 2 -C 12 )alkynyl, —NH 2 , —NH(C 1 -C 12 )alkyl, —N((C 1 -C 12 )alkyl) 2 , aryl, (C 1 -C 12 )alkaryl, aryl(C 1 -C 12 )alkyl, or aryl-substituted aryl(C 1 -C 12 )alkyl; each R 3 is independently halo, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkoxyl, (C 3 -C 10 )cycloalkyl, (C 2 -C 12 )alkenyl, (C 2 -C 12 )alkynyl, —NH2, —NH(C 1 -C 12 ) alkyl, —N((C 1 -C 12 )alkyl) 2 , aryl, (C 1 -C 12 )alkaryl, aryl(C 1 -C 12 )alkyl, or aryl-substituted aryl(C 1 -C 12 )alkyl; R 4 is (C 6 -C 24 )alkyl, halo(C 6 -C 24 )alkyl, (C 6 -C 24 )alkoxy, —NH2, —NH(C 1 -C 24 )alkyl, —N((C 1 -C 24 )alkyl) 2 , cyano, (C 3 -C 10 )cycloalkyl, (C 4 -C 15 )bicycloalkyl, (C 6 -C 24 )alkenyl, (C 6 -C 24 )alkenyl, (C 6 -C 24 )-alkynyl, aryl, (C 6 -C 24 )alkaryl, aryl(C 6 -C 24 )alkyl, or aryl-substituted aryl(C 6 -C 24 )alkyl; wherein the alkyl, alkenyl aryl groups of R4 can be optionally substituted with halo, alkoxy or cyano; or R 5 and R 6 are independently hydroxy, (C 1 -C 12 )alkyl-O—, (C 2 -C 12 )alkenyl-O—, (C 2 -C 12 )alkynyl-O—, (C 6 -C 10 )aryl-O—, m is 0, 1, 2, 3, or 4; n is 0, 1, 2, or 3; or a pharmaceutically acceptable salt or ester thereof.