Patent ID: 8883987

Claim:
An immune stimulating composition comprising: a) bacterial DNA fragments; and b) non-toxic bacterial lipopolysaccharides, wherein CpG sequences of bacterial DNA fragments are methylated, wherein the bacterial DNA fragments have size ranging from 0.5 kb to 2.0 kb and exclude unmethylated CpG, and wherein the non-toxic bacterial lipopolysaccharides are Escherichia coli lipopolysaccharides or mycobacteria lipopolysaccharides, have size ranging from 3,000 to 10,000 daltons, and have a degraded lipid A; wherein the degraded lipid A is produced from non-degraded lipid A by treatment with an alkaline; and wherein the non-toxic bacterial lipopolysaccharides produce an inflammatory reaction that is at least 50 fold less than an inflammatory reaction produced by control lipopolysaccharides.