Patent ID: 8349812

Claim:
An isolated oligoribonucleotide (ORN) comprising a 5′-triphosphate analog provided as or a pharmaceutically acceptable salt of said ORN; wherein X 1 is selected from O, S, and NH and is linked to a 5′ carbon of a 5′ terminal nucleotide of the ORN; X 2 and each X 3 , when present, are independently selected from O, S, NH, CH 2 , CCl 2 , CHF, and CF 2 ; X 4 is selected from OH, OR, SH, NHR, R, imidazole, and Nu-O—P(Z)(Y)X 3 , wherein R is selected from a C 1 -C 12 alkyl and a C 6 -C 10 aryl, and wherein Nu is a nucleoside; each Y is independently selected from O, S, and NH; and each Z is independently selected from H, OH, SH, NH 2 , NHR′, BH 3 , CF 2 H, OPO 3 H, OR′, and R′, wherein R′ is selected from C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkinyl, C 6 -C 10 aryl, and C 7 -C 22 alkylaryl; and n is an integer between 0 and 3, inclusive, provided that n is 0 only when X 4 is imidazole; with the proviso that the 5′-triphosphate analog is not 5′-triphosphate.