Patent ID: 7834180

Claim:
A method for preparing a compound having formula 1: or a pharmaceutically acceptable salt thereof, wherein: A, V, and Z are independently H, halo, azido, R 2 , CH 2 R 2 , SR 2 , OR 2 or NR 1 R 2 ; W is NR 1 R 2 or OR 6 wherein R 6 is a C 1-10 alkyl; X is NR 1 ; each R 1 is H or a C 1-6 alkyl; each R 2 is H, or a C 1-10 alkyl or C 2 - 10 alkenyl each optionally substituted with a halogen, a carbocyclic ring, a heterocyclic ring, an aryl or heteroaryl, wherein each ring is optionally substituted; or R 1 and R 2 together with N may form an optionally substituted heterocyclic ring containing one or more N, O, or S; R is a substituent at any position on B′; and is H, OR 2 , amino, alkoxy, amido, halogen, cyano; or R is C 1-6 alkyl, C 2-6 alkenyl, or —CONHR 1 ; B′ is an optionally substituted phenyl ring; n is 0-4; comprising: contacting a compound having formula (6A) wherein each L and L 1 is a leaving group; and A, V, and Z are as defined in formula (1); with a compound having formula (7) or tautomers thereof wherein n, X, B′ and R are as defined in formula (1); and W is OR 6 wherein R 6 is a C 1-10 alkyl; or W is NR 1 R 2 , wherein R 1 and R 2 are as defined in formula (1); wherein said compound having formula (6A) is contacted with said compound having formula (7) or tautomers thereof in the presence of a non-nucleophilic base to produce a compound having formula (1); and wherein each optionally substituted group is unsubstituted or is substituted with one or more halo, OR 2 , NR 1 R 2 , C 1-10 alkyl, C 2-10 alkenyl, each optionally substituted by halo, or aryl; or a carbocyclic or a heterocyclic ring; where R 1 and R 2 are as defined above.