Patent ID: 7286970

Claim:
A method for tailoring multidrug chemotherapy treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to drugs used in such treatments, said method comprising the steps of: providing a set of differential equations representing a mathematical model of rates of population change of proliferating and quiescent diseased cells, said mathematical model including parameters corresponding to cell kinetics and evolution of drug resistance of the diseased cells to cell-cycle phase-specific cytotoxic drugs, cell-cycle phase non-specific cytotoxic drugs, and cytostatic drugs; obtaining cell kinetic parameter values from an individual patient including proliferative index, apoptotic index, S-phase fraction, cell cycle time, and level of drug resistance; using the cell kinetic parameter values obtained from the patient to solve the set of differential equations of the mathematical model to determine a plurality of treatment regimens for the patient, each of said treatment regimens having a quantitative efficacy value associated therewith representing the efficacy thereof in reducing the diseased cell population of the patient; and selecting one of the treatment regimens having an efficacy value that is desirable for treating the patient, said selected treatment regimen thereby being tailored to the patient.