Patent ID: 8354092

Claim:
A compound comprising the Formula IIa 2 : or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixtures of stereoisomers thereof, wherein: G is a bond or is selected from the group consisting of cycloalkyl, aryl-CH(Y)—, heterocyclyl, aryl and heteroaryl, wherein said cycloalkyl, aryl-CH(Y)—, heterocyclyl, aryl and heteroaryl are substituted or unsubstituted; n is 0, 1, 2 or 3; X is a bond or is selected from the group consisting of —O—, —S—, —S(O)—, —S(O) 2 —, —NR°— where R° is H, C 1-5 alkyl or CH 2 CO 2 R″ wherein R″ is H or C 1 -C 3 -alkyl; —NR°—C(O)—CH(R°)— where R° is H or C 1-5 alkyl; heterocyclyl, aryl, heteroaryl and C 1-6 alkyl wherein 1 or 2 carbon atoms of the C 1-6 alkyl is replaced by a —O—, —C(O)—, —S—, —S(O)—, —S(O) 2 — or —NR″′— where R″′ is H or C 1-5 alkyl, and where the C 1-6 alkyl is optionally substituted with 1 or 2 substituents selected from the group consisting of —OH, —SH, NH 2 , heterocyclyl, aryl and heteroaryl; X′ is selected from the group consisting of a quaternary ammonium salt, imidate salt, thiolate salt, oxonium cation, boron-amine salt, pyridinium salt, and Z′-D, where D comprises a charged moiety that is at least one of a cation or anion, —SO 2 H, —SO 3 H, —PO 3 H, —OPO 3 H, N-oxide, —B(OH) 2 , —OH, amino, halo, —CF 3 , —CH 2 F, —CHF 2 , —COOH, —COOC 1-5 alkyl, —COC 1-5 alkyl, —CO-aryl, —CO-heteroaryl, C 1-6 alkyl, amino-C 1-5 alkyl-, optionally substituted aryl, optionally substituted heteroaryl, halo-C 1-5 alkyl, halo-C 1-5 alkoxy-; Z′—C 1-6 alkyl, Z′—C 2-6 alkyl-O—, Z′—C 2-6 alkyl-O—C 1-3 alkyl-, Z′—C 2-6 alkyl-S—, Z′—C 2-6 alkyl-NH—, Z′—C 2-6 alkyl-NH—C 1-3 alkyl-, Z′—C 2-6 alkyl-N(C 1-3 alkyl)-C 1-3 alkyl-, Z′—(CH 2 CH 2 —O) 1-5 —, wherein Z′ is selected from the group consisting of halo, radionuclide, —CF 3 , —CH 2 F, —CHF 2 , aryl, and heteroaryl, wherein at least one H of aryl or heteroaryl is substituted with a halo or a radionuclide; Y is H or is selected from the group consisting of a quaternary ammonium salt, imidate salt, thiolate salt, oxonium cation, boron-amine salt, pyridinium salt, —SO 2 H, N-oxide, —B(OH) 2 , —COOR″, —SO 3 R″, —P(O) 2 OR″ and —OP(O) 2 OR″ wherein R″ is H or C 1-3 alkyl; R is H, or is selected from the group consisting of a side chain of an amino acid, halobenzyl, —C 1-5 alkyl-, —C 1-5 alkyl-OR″, —C 1-5 alkyl-N(R″) 2 ,—C 1-5 alkyl-NR″C(O)—(CH 2 CH 2 O) m —C 1 -C 5 -alkyl-CO 2 R″ wherein m is 0-8, —C 1-5 alkyl-NR″C(O)—C 1 -C 5 -alkyl wherein the —C 1-5 alkyl is optionally substituted with OR″ or CH 2 OR″, —C 1-5 alkyl-o, m, or p-aryl- (O—CH 2 CH 2 ) 1-5 -halo wherein the —(O—CH 2 CH 2 ) 1-5 -halo is optionally substituted with one or more OR″, or —C 1-5 alkyl-o, m, or p-aryl-(CH 2 CH 2 ) 1-5 -halo, wherein R″ is H or C 1 -C 3 -alkyl; and Z is a bond or is selected from the group consisting of —C(O)—NH—CH 2 —, —CH 2 O—, and —OCH 2 — wherein at least one of X′ or Y is comprised of an ionizable group.