Patent ID: 6908934

Claim:
A compound of Formula I: and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia and (b) Formula lb wherein Formula Ib represents a saturated heterocyclic ring containing one tertiary nitrogen atom and 5 or 6 carbon atoms, wherein each carbon atom is independently unsubstituted or substituted with at least one substituent selected from the group consisting of: (i) —C 1-4 alkyl, (ii) phenyl, unsubstituted or substituted with at least one —C 1-4 alkyl substituent, (iii) —CH 2 -phenyl, wherein phenyl is unsubstituted or substituted with at leant one —C 1-4 alkyl substituent, (iv) —COOH and (v) —COOC 1-4 alkyl; X is selected from the group consisting of: (a) —NH, and (b) —CH 2 —; R 1 is selected from the group consisting of: (a) —H, (b) —OH and (c) —OC(O)CH 3 ; R 2 and R 3 are independently selected from the group consisting of: (a) —H and (b) —C 1-4 alkyl, or R 2 and R 3 together represent ═O; n is an integer selected from zero and 1; R 4 and R 5 represent moieties selected from those defined in the following groups: (a) R 4 and R 5 are independently selected from the group consisting of (i) —H and (ii) phenyl, unsubstituted or substituted with a group selected from halo, —C 1-4 alkyl and —O—C 1-4 alkyl, (b) R 4 and R 5 together represent —(CH 2 ) m — which joins together with the carbon in Formula Ia to which R 4 and R 5 are commonly attached to form a cycloalkyl ring, and wherein m is an integer selected from 2 through 5, (c) R 4 and R 5 are each alkyl groups joined together with the carbon in Formula Ia to which they are commonly attached to form a carbon-bridged polycycloalkyl ring system selected from isopinylcampheyl and adamantyl, wherein the ring system is unsubstituted or substituted with —C 1-4 alkyl, (d) R 4 , R 5 and R 6 are each alkyl groups joined together with the carbon in Formula Ia to which they are commonly attached to form a carbon-bridged polycycloalkyl ring system which is adamantyl, wherein the ring system is unsubstituted or substituted with —C 1-4 alkyl, and (e) R 4 , R 5 and R 6 together with the carbon in Formula Ia to which they are commonly attached represent provided R 6 is not joined together with R 4 and R 5 as described above, then R 6 is selected from the group consisting of: (a) —H and (b) phenyl, unsubstituted or substituted with a group selected from halo, —C 1-4 alkyl and —O—C 1-4 alkyl, except that when R 4 and R 5 are each alkyl groups joined together with the carbon in Formula Ia to which they are commonly attached to form a carbon-bridged polycycloalkyl ring system, then R 6 is —H; R 7 is selected from the group consisting of: (a) —H, (b) —OH and (c) —OC(O)CH 3 ; and provided that when n is 1, and R 2 and R 3 together represent ═O, R 4 , R 5 and R 6 together with the carbon in Formula I to which they are commonly attached represent and R 1 is —OC(O)CH 3 and R 7 is —OC(O)CH 3 , then X is not —O—.