Patent ID: 8658670

Claim:
A method of treating a Clostridium difficile based infection in a mammal comprising administering to the mammal an effective amount of a MetRS inhibitor compound represented by a compound of formula (IIa): in which: X is selected from the group consisting of NH, O, S, SO, SO 2 , or CH 2 ; n is 1, 2 or 3; * indicates an asymmetric carbon atom, wherein when n is 2 or 3, then * is R configuration; wherein when n is 1 and X is CH 2 , then * is R configuration; and wherein when n is 1 and X is selected from the group consisting of NH, O, S, SO, or SO 2 , then * is S configuration; m is 0, 1, 2, 3, or 4; R 1 is independently selected from halo, cyano, hydroxyl, (C 1-6 )alkyl (optionally substituted by halo, hydroxyl, amino, carboxy, or (C 1-6 )alkoxycarbonyl), (C 3-7 )cycloalkyl, C( 1-6 )alkoxy, amino, mono- or di-(C 1-6 )alkylamino, acylamino, carboxy, (C 1-6 )alkoxycarbonyl, carboxy(C 1-6 )alkyloxy, (C 1-6 )alkylthio, (C 1-6 )alkylsulphinyl, (C 1-6 )alkylsulphonyl, sulphamoyl, mono- and di-(C 1-6 )alkylsulphamoyl, carbamoyl, mono- and di-(C 1-6 )alkylcarbamoyl and heterocyclic; R 2 is independently selected from halo, cyano, hydroxyl, (C 1-6 )alkyl (optionally substituted by halo, hydroxyl, amino, carboxy, or (C 1-6 )alkoxycarbonyl), (C 3-7 )cycloalkyl, C( 1-6 )alkoxy, amino, mono- or di-(C 1-6 )alkylamino, acylamino, carboxy, (C 1-6 )alkoxycarbonyl, carboxy(C 1-6 )alkyloxy, (C 1-6 )alkylthio, (C 1-6 )alkylsulphinyl, (C 1-6 )alkylsulphonyl, sulphamoyl, mono- and di-(C 1-6 )alkylsulphamoyl, carbamoyl, mono- and di-(C 1-6 )alkylcarbamoyl and heterocyclic; and when Z 1 is S, Z 2 and Z 3 are CH; when Z 2 is S, Z 1 and Z 3 are CH; and when Z 3 is S, Z 1 and Z 2 are CH.