Patent ID: 8741580

Claim:
A method for the diagnosis and/or prognosis of renal damage in a human patient, said renal damage being caused by chronic transplant rejection following renal transplantation, the method comprising (i) detecting the presence or amount of an autoantibody against at least one marker protein in a sample from said patient, said autoantibody being at least one of an IgG autoantibody and an IgM autoantibody, said sample being selected from the group consisting of a renal tissue sample, a blood sample, a serum sample, a plasma sample and a urine sample; (ii) comparing the detected autoantibody to a control sample, wherein the presence or altered amount of said at least one marker protein in said patient sample, as represented by said detected presence or amount of the autoantibody, in comparison to said autoantibody level in said control sample, is indicative of said renal damage in said patient, and wherein said at least one marker protein is selected from the group consisting of Ig μ chain C region protein; C4b-binding protein α-chain precursor; heparin cofactor II precursor; N-acetylmuramoyl-L-alanine amidase precursor; complement component C9 precursor; β2-glycoprotein I precursor; leucine-rich α 2 -glycoprotein precursor; complement C3 precursor; AMBP protein precursor (α-1-microglobulin); adiponectin; complement factor D precursor; ceruloplasmin precursor (ferroxidase); pigment epithelium-derived factor precursor; translation initiation factor 3 subunit 10; plasma retinol-binding protein precursor; α 1B -glycoprotein.