Patent ID: 8461385

Claim:
In a method of preparing an N-substituted salicylamide, wherein the N-substituted salicylamide is achieved by reaction of a carsalam derivative with ethyl-8-bromooctoanoate, the improvement comprising: reacting the carsalam derivative with a chloro-substituted compound of formula (III) wherein n is an integer from 1 to 8, Q represents a group readily convertible to a carboxylic acid moiety and R 5 and R 6 are independently selected from hydrogen, —OH, NR 3 R 4 , halogen, C 1 , C 2 , C 3 or C 4 alkyl, C 1 , C 2 , C 3 or C 4 alkoxy, C 2 , C 3 or C 4 alkenyl where R 3 and R 4 are each independently selected from hydrogen, —OH, C 1 , C 2 , C 3 or C 4 alkyl, C 1 , C 2 , C 3 or C 4 haloalkyl, C 1 , C 2 , C 3 or C 4 alkoxy, C 2 , C 3 or C 4 alkenyl, wherein said reacting step is carried out by mixing in an inert atmosphere and in the presence of an aprotic solvent, the carsalam derivative with 1 equivalent of the chloro-substituted compound of formula III and 0.2 equivalents an alkali metal-bromide, heating to 100-105° C., followed by slow addition of 0.55 equivalents of an alkali metal hydroxide base or an alkali metal carbonate base.