Patent ID: 7763643

Claim:
A method for treating acute kidney failure or chronic kidney failure, in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound of formula I or a pharmaceutically acceptable salt thereof wherein: R1 and R2 are, independently, H, F, Cl, Br, I, CN, NO 2 , —(X) n —C q H 2q —Z, cycloalkyl having 3, 4, 5 or 6 carbon atoms, alkenyl having 2, 3 or 4 carbon atoms, alkenylalkyl having 3 or 4 carbon atoms, ethynyl, or alkylalkynyl having 3 or 4 carbon atoms, wherein n is zero or 1; X is oxygen, NH, N—CH 3 , or S(O) k , wherein k is zero, 1 or 2; q is zero, 1, 2, 3, 4, 5 or 6; and Z is hydrogen or C m F 2m+1 , wherein m is zero, 1, 2, 3 or 4; R3 is hydrogen, methyl, F, Cl, Br, I, CN, S(O) k —CH 3 , —NO 2 , or —O—CH 3 , wherein k is zero, 1 or 2; R4 is hydrogen, cycloalkyl having 3, 4, 5, or 6 carbon atoms, alkenyl having 2, 3 or 4 carbon atoms, alkenylalkyl having 3 or 4 carbon atoms, ethynyl, alkylalkynyl having 3 or 4 carbon atoms, or —C r H 2r —Y, wherein r is zero, 1, 2, 3 or 4; and Y is hydrogen or trifluoromethyl; R5 and R6 are hydrogen or are together a bond; and R7 and R8 are, independently, (C 3 -C 5 )-alkyl, (C 2 -C 5 )-alkenyl, (C 2 -C 5 )-alkynyl, (C 3 -C 6 )-cycloalkyl or (C 4 -C 6 )-cycloalkenyl; or R7 and R8 taken together with the two carbon atoms to which R7 and R8 are attached, form a (C 5 -C 10 ) cycloalkyl ring which may be unsubstituted or substituted with one or more fluorine atoms; or R7 and R8 taken together with the two carbon atoms to which R7 and R8 are attached, form a ring of the following formula wherein R10 and R11 are, independently, hydrogen, fluorine, chlorine, bromine, methyl, CN, OH, —O—CH 3 , NO 2 , NH 2 or —CF 3 ; R9 and R12 are hydrogen or F; or R9 is hydrogen and R12 is F, Cl, Br, I, CN, NO 2 , COOH, CO—NR13R14, SO 2 —NR13R14, alkenyl having 2, 3 or 4 carbon atoms, alkenylalkyl having 3 or 4 carbon atoms, ethynyl, alkylalkynyl having 3 or 4 carbon atoms, or —(XI) n —C q H 2q —Z; or R12 is hydrogen and R9 is F, Cl, Br, I, CN, NO 2 , COOH, CO—NR13R14, SO 2 —NR13R14, alkenyl having 2, 3 or 4 carbon atoms, alkenylalkyl having 3 or 4 carbon atoms, ethynyl, alkylalkynyl having 3 or 4 carbon atoms, or —(XI) n —C q H 2q —Z; wherein: R13 is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms and R14 is hydrogen or alkyl having 1, 2, 3, or 4 carbon atoms; or R13 and R14 together with the nitrogen to which they are attached form a saturated 5-, 6- or 7-membered ring; n is zero or 1; XI is oxygen, NH, N—CH 3 , or S(O) k ; k is zero, 1 or 2; q is zero, 1, 2, 3, 4, 5 or 6; and Z is hydrogen or C m F 2m+1 , wherein m is zero, 1, 2, 3 or 4.