Patent ID: 7053070

Claim:
A compound of the Formula I and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, wherein: R 2 , R 7 , R 13 , R 14 , and R 15 are independently hydrogen, or lower alkyl, lower alkenyl, lower alkynyl, or —(CH 2 ) n R 12 each of which is optionally substituted with up to 5 groups independently selected from halogen, cyano, nitro, —R 9 , —NR 9 R 10 , —OR 9 , —(CH 2 ) n CO 2 R 9 , —(CH 2 ) n SO 2 R 11 , —(CH 2 ) n R 11 , —COR 9 , —CONR 9 R 10 , —SO 3 R 9 , —SO 2 NR 9 R 10 , —SO 2 R 9 , —SR 9 , —PO 3 R 9 R 10 , —POR 9 R 10 , —PO(NR 9 R 10 ) 2 , —NR 9 COR 10 , —NR 9 CO 2 R 10 , —NR 9 CONR 9 R 10 , —NR 9 SO 2 R 10 , or a heterocycle optionally substituted with up to 3 groups independently selected from —R 9 , —NR 9 R 10 , —OR 9 , —NR 9 COR 10 , —COR 10 , —(CH 2 ) n SO 2 R 11 , —(CH 2 ) n R 11 ; R 5 is halogen, cyano, nitro, —R 9 , —NR 9 R 10 , or —OR 9 ; R 6 is halogen, cyano, nitro, —R 9 , —NR 9 R 10 , —OR 9 , —CO 2 R 9 , —COR 9 , —CONR 9 R 10 , —NR 9 COR 10 , —SO 2 NR 9 R 10 , —SO 2 R 9 , —SR 9 , —PO 3 R 9 R 10 , —POR 9 R 10 , —PO(NR 9 R 10 ) 2 , or lower alkenyl or lower alkynyl optionally substituted with —R 9 ; R 8 is H, —CO 2 R 13 , —COR 13 , —CONR 13 R 14 , —CSNR 13 R 14 , —C(NR 13 )NR 14 R 15 , —SO 3 R 13 , —SO 2 R 13 , —SO 2 NR 13 R 14 , —PO 3 R 13 R 14 , —POR 13 R 14 , or —PO(NR 13 R 14 ) 2 ; R 9 and R 10 are independently hydrogen, or lower alkyl, optionally substituted with up to 3 groups selected from the group consisting of halogen, amino, mono- or dialkylamino, hydroxy, lower alkoxy, phenyl and substituted phenyl, or when taken together with the nitrogen to which they are attached, R 9 and R 10 form a ring having from 3-7 members, up to four of which may be selected from the group consisting of O, S, and NR 20 , where R 20 is hydrogen, lower alkyl, or —CO lower alkyl; R 11 is a heteroaryl or a heterocyclic group; R 12 is a cycloalkyl, a heterocyclic, an aryl, or a heteroaryl group; and Each n is independently 0, 1, 2, or 3.