Patent ID: 7572934

Claim:
A compound having the formula I: or a pharmaceutically acceptable salt, solvate, stereoisomer, or C 1 -C 6 alkyl ester thereof; or a tautomer or a pharmaceutically acceptable salt, solvate, stereoisomer, or C 1 -C 6 alkyl ester thereof; or a mixture thereof, wherein X is O or S; W, Y, and Z are selected from N or C—H; wherein no more than one of W, Y, and Z is N; and further wherein Z is not N if R 2 is F; R 1 is selected from H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, heterocyclyl, or heteroaryl; R 1a is selectod from H and (C 1 -C 4 )alkyl; R 2 is selected from F or (C 3 -C 6 )alkoxy; R 3 is (C 1 -C 2 )alkoxy; R 4 , R 5 , and R 6 are independently slected from H, (C 1 -C 4 )alkyl, or substituted (C 1 -C 4 )alkyl, and two of R 4 , R 5 , and R 6 may join together to form a 3-7 membered ring; wherein at least two of R 4 , R 5 , and R 6 are other than H; R 7 and R 8 are independently selected from H and (C 1 -C 4 )alkyl; R 9 and R 10 are independently selected from H and (C 1 -C 4 )alkyl; Each R 11 is independently selected from F, Cl, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkoxy and m is 0, 1, or 2; and Each R 12 is independently selected from F, Cl, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkoxy and n is 0, 1, or 2.