Patent ID: 8685919

Claim:
A compound having the formula R 1 -X-Z-R 2 wherein R 1 is H, C 1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; R 2 is OH or NH 2 ; X is a peptide which has the formula I: (SEQâ€ƒIDâ€ƒNO:â€ƒ4) His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys- Tyr-Leu-Asp-Ser-Lys-Ala-Ala-His-Asp-Phe-Val-Glu- Trp-Leu-Leu-Arg-Ala or differs from formula I at up to 4 of the following positions whereby, if different from formula I: the residue at position 2 is selected from: Aib, D-Ser; the residue at position 16 is Lys; the residue at position 17 is selected from: Arg, Leu; the residue at position 18 is Arg; the residue at position 20 is selected from: Gln, Lys, Arg; the residue at position 24 is selected from: Gln, Lys, Arg; the residue at position 27 is selected from: Met, Lys; the residue at position 28 is selected from: Asn, Leu; and the residue at position 29 is Thr; and Z is absent or a peptide sequence of 1-20 amino acid units selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr and Orn; or a pharmaceutically acceptable salt thereof.