Patent ID: 8063038

Claim:
A compound according to formula 1, or a compound which is a tautomer or a pharmaceutically acceptable salt thereof, wherein: W is selected from N and CR 4 ; X is selected from CH(R 8 ), O, S, N(R 8 ), C(═O), C(═O)O, C(═O)N(R 8 ), OC(═O), N(R 8 )C(═O), C(R 8 )═CH, and C(═R 8 ); G 1 is a bicyclic or tricyclic fused azepine derivative selected from general formulae 2 to 9 or an aniline derivative according to general formula 10 A 1 , A 4 , A 7 and A 10 are each independently selected from CH 2 , C═O, O, and NR 10 ; A 2 , A 3 , A 9 , A 11 , A 13 , A 14 , A 15 , A 19 , and A 20 are each independently selected from CH and N; either A 5 is a covalent bond, and A 6 is S; or A 5 is N═CH, and A 6 is a covalent bond; A 8 , A 12 , A 18 , and A 21 are each independently selected from CH═CH, NH, NCH 3 , and S; A 16 and A 17 are both CH 2 , or one of A 16 and A 17 is CH 2 , and the other is selected from C═O, CH(OH), CF 2 , O, SO c , and NR 10 ; Y is selected from CH═CH or S; R 1 and R 2 are independently selected from H, F, Cl, Br, alkyl, CF 3 , and O-alkyl; R 3 is selected from H and alkyl; R 4 -R 7 are independently selected from H, F, Cl, Br, alkyl, CF 3 , OH, and O-alkyl; R 8 is selected from H, (CH 2 ) b R 9 , and (C═O)(CH 2 ) b R 9 ; R 9 is selected from H, alkyl, optionally substituted aryl, optionally substituted heteroaryl, OH, O-alkyl, OC(═O)alkyl, NH 2 , NHalkyl, N(alkyl) 2 , CHO, CO 2 H, CO 2 alkyl, CONH 2 , CONHalkyl, CON(alkyl) 2 , and CN; R 10 is selected from H, alkyl, COalkyl, and (CH 2 ) d OH; R 11 is selected from alkyl, (CH 2 ) d Ar, (CH 2 ) d OH, (CH 2 ) d NH 2 , (CH 2 ) d COOalkyl, (CH 2 ) d COOH, and (CH 2 ) d OAr; R 12 and R 13 are each independently selected from H, alkyl, F, Cl, Br, CH(OCH 3 ) 2 , CHF 2 , CF 3 , COOalkyl, CONHalkyl, (CH 2 ) d NHCH 2 Ar, CON(alkyl) 2 , CHO, COOH, (CH 2 ) d OH, (CH 2 ) d NH 2 , N(alkyl) 2 , CONH(CH 2 ) d Ar, and Ar; Ar is selected from optionally substituted heterocycles or optionally substituted phenyl; a is selected among 1, 2 and 3; b is selected among 1, 2, 3 and 4; c is selected among 0, 1 and 2; and d is selected among 0, 1, 2 and 3.