Patent ID: 8772236

Claim:
A proteinmimic of a member of the cystine-knot growth factor superfamily, wherein the proteinmimic comprises a motif X0-C1-X1-C2-X2-C3-X3-C4-X4-C5-X5-C6-X6 (SEQ ID NO:2), wherein C1 to C6 are cysteine residues that form a cystine-knot structure in which C1 is linked to C4, C2 is linked to C5, and C3 is linked to C6, wherein X0 comprises KFMDVYQRSY (amino acids 1-10 of SEQ ID NO:12), X1 comprises HPIETLVDIFQEYPDEIEYIFKPSAVPLMR (amino acids 2-31 of SEQ ID NO:27), X2 comprises GGA, X3 comprises NDEGLE (amino acids 37-42 of SEQ ID NO:27), X4 comprises VPTEESNITMQIMRIKPHQGQHIGEMSFLQHNK (amino acids 44-76 of SEQ ID NO:27), X5 comprises E, and X6 comprises RPKKDRARQE (amino acids 90-99 of SEQ ID NO:12), or wherein said protein mimic consists of a sequence having at least 95% sequence identity to SEQ ID NO:27; wherein said protein mimic comprises the consensus sequence P[PSR]CVXXXRC2[GSTA]GCC3 (SEQ ID NO:5) wherein at least one cysteine, other than C2 or C3, is replaced by another amino acid residue and wherein X means any amino acid, [PSR] means P or S or R and [GSTA] means G or S or T or A.