Patent ID: 7105292

Claim:
A screening method for the detection of a compound that modulates a response of a cell to ultraviolet radiation exposure, comprising: (a) contacting the cell with the compound; (b) exposing the cell to ultraviolet radiation that would otherwise induce the response, the response being a pattern of expression comprising a first response, a second response, and a third response, the third response comprising altered expression of at least one nucleic acid molecule encoding an actin-binding protein, at least one nucleic acid molecule encoding a desmosomal protein, and at least one nucleic acid molecule encoding a tubulin protein; and (c) measuring the levels of a plurality of RNA molecules in the cell for at least one time point after ultraviolet radiation exposure so as to determine whether a change in the altered expression of the third response has occurred, wherein a change in the altered expression of the third response indicates that the compound modulates the response of the cell to ultraviolet radiation exposure.