Patent ID: 8158129

Claim:
A method of treating cancer or a viral infection comprising: a) obtaining a PEGylated interferon-α (IFN-α) or interferon-β (IFN-β) complex comprising; i) a PEG (polyethylene glycol) moiety covalently attached to a first peptide; ii) a fusion protein comprising IFN-α or IFN-β and a second peptide; and b) administering the PEGylated IFN-α or IFN-β complex to a subject with cancer, a viral infection or autoimmune disease; wherein two copies of the second peptide form a dimer that binds to the first peptide to form a PEGylated complex, wherein the amino acid sequence of the second peptide is selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2, and the amino acid sequence of the first peptide is selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9.