Patent ID: 8367111

Claim:
A pharmaceutical dosage form comprising sustained release (SR) beads and optionally immediate release (IR) beads, wherein: a. said IR beads comprise core particles comprising propranolol or a pharmaceutically acceptable salt thereof, and mixtures thereof; and b. said SR beads comprise core particles comprising propranolol or a pharmaceutically acceptable salt thereof, and mixtures thereof; and a membrane comprising a water insoluble polymer or a combination of a water insoluble polymer and a water soluble polymer, wherein said pharmaceutical dosage form when tested according to United States Pharmacopoeia dissolution test method USP Apparatus 1, Baskets @ 100 rpm, Drug Release Test 1 using 900 mL of pH 1.2 buffer for 1.5 hours followed by testing in 900 mL of pH 6.8 at 4, 8, 14, and 24 hours, exhibits the following dissolution profile: after 1.5 hours, not more than about 30% of the total propranolol is released; after 4 hours, about 45±15% of the total propranolol is released; after 8 hours, about 65±15% of the total propranolol is released; after 14 hours, about 80±15% of the total propranolol is released; and after 24 hours, not less than about 85% of the total propranolol is released.