Patent ID: 8435946

Claim:
A solid pharmaceutical composition suitable for the oral delivery of a pharmacologically active agent comprising a. a pharmacologically active polypeptide agent; b. pharmaceutically acceptable inactive excipients, and c. a delivery agent of formula I for said pharmacologically active polypeptide agent wherein R 1 , R 2 , R 3 , and R 4 are independently hydrogen, —OH, —NR 8 R 7 , halogen, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy; R 5 is a substituted or unsubstituted C 2 -C 16 alkylene, substituted or unsubstituted C 2 -C 16 alkenylene, substituted or unsubstituted C 1 -C 12 alkyl(arylene), or substituted or unsubstituted aryl(C 1 -C 12 alkylene); and R 6 and R 7 are independently hydrogen, oxygen, or C 1 -C 4 alkyl; and hydrates, pharmaceutically acceptable salts and solvates thereof, wherein said delivery agent is in micronized form and has an average particle size of less than 10 microns.