Patent ID: 8067570

Claim:
A double-stranded compound having the structure: 5′ (N) x -Z 3′ (antisense strand) 3′ Z′-(N′) y 5′ (sense strand) wherein each N and N′ is a ribonucleotide which may be modified or unmodified in its sugar residue and each of (N) x and (N′) y is an oligomer in which each consecutive N or N′ is joined to the next N or N′ by a covalent bond; wherein each of x and y is an integer between 19 and 40 inclusive; wherein each of Z and Z′ may be present or absent, but if present is dTdT and is covalently attached at the 3′ terminus of the strand in which it is present; and wherein the sequence of (N) x comprises a sequence set forth in either of SEQ ID NOs: 525 or 528.