Patent ID: 7655792

Claim:
In a method for the separation and/or purification of a genomic DNA from cells, comprising: a) generating an aqueous solution containing the genomic DNA by lysing said cells with a lysis solution; b) contacting said aqueous solution containing the genomic DNA with an anion exchanger bound to a solid support matrix under conditions such that the anion exchanger binds the genomic DNA; c) eluting the genomic DNA from said anion exchanger with an aqueous mobile phase comprising a basic nucleic acid elution solution; and d) desalting said eluted genomic DNA such that it is suitable for downstream applications; the improvement comprises adding in said basic elution solution potassium carbonate such that the pH of said aqueous mobile phase is between about pH 10 and about pH 12, wherein the presence of said composition in the elution solution provides an increase in the genomic DNA recovery from the anion exchanger, as compared with the recovery of said genomic DNA in the absence of said composition.