Patent ID: 8912319

Claim:
A method of synthesizing 2′-deoxy-2′-[ 18 F]-fluoro-5-substituted-1-β-D-arabinofuranosyl-uracil or -cytosine compounds in a one-pot reaction comprising: a) radiolabeling a precursor sugar with 18 F; b) contacting the 18 F radiolabeled sugar with a silylated uracil or cytosine in the presence of trimethylsilyl trifluorosulfonate (TMS-O-Tf) and hexamethyldisilazane (HMDS); c) incubating the components in step (b) under conditions which allow for conjugation of the 18 F radiolabeled sugar and the silylated uracil or cytosine; d) removing the protecting groups of the components in step (c); and e) purifying the deprotected product.