Patent ID: 7923445

Claim:
A method of inducing apoptosis in an immune cell, the method comprising contacting the immune cell with a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is independently selected at each occurrence from hydrogen, halogen, (C 1 -C 6 )alkyl; (C 1 -C 6 )alkenyl; (C 1 -C 6 )alkoxy; OH; NO 2 ; C≡N; C(═O)OR 7 ; C(═O)NR 7 2 ; NR 7 2 ; NR 7 C(═O)(C 1 -C 6 )alkyl; NR 7 C(═O)O(C 1 -C 6 )alkyl; NR 7 C(═O)NR 7 2 ; NR 7 SO 2 (C 1 -C 6 )alkyl; SO 2 NR 7 2 ; OC(═O)(C 1 -C 6 )alkyl; O(C 2 -C 6 )alkylene-NR 7 2 ; (C 2 -C 6 )alkylene-OR 7 ; and (C 1 -C 3 )perfluoroalkyl; R 2 is independently selected at each occurrence from hydrogen, halogen, (C 1 -C 6 )alkyl; (C 1 -C 6 )alkenyl; (C 1 -C 6 )alkoxy; OH; NO 2 ; C≡N; C(═O)OR 7 ; C(═O)NR 7 2 ; NR 7 2 ; NR 7 C(═O)(C 1 -C 6 )alkyl; NR 7 C(═O)O(C 1 -C 6 )alkyl; NR 7 C(═O)NR 7 2 ; NR 7 SO 2 (C 1 -C 6 )alkyl; SO 2 NR 7 2 ; OC(═O)(C 1 -C 6 )alkyl; O(C 2 -C 6 )alkylene-NR 7 2 ; (C 2 -C 6 )alkylene-OR 7 ; and (C 1 -C 3 )perfluoroalkyl; R 3 is hydrogen, C(═O)OR 7 , or C(═O)NR 7 2 ; A 1 is CH 2 or NR 4 ; A 2 is CH or N; provided that if A 1 is CH 2 , then A 2 is N, and if A 2 is CH, then A 1 is NR 4 ; R 4 is (CH 2 ) p NHC(O)R 5 ; (CH 2 ) p O(CH 2 ) p OR 7 ; (CH 2 ) p O(CH 2 ) p NR 7 2 ; (CH 2 ) p NR 4 (CH 2 ) p NR 7 2 ; (CH 2 ) p O(CH 2 ) p NHC(O)R 5 ; (CH 2 ) p NR 7 (CH 2 ) p NHC(O)R 5 ; (CH 2 ) q C(═O)OR 7 ; (CH 2 ) q C(═O)NR 7 2 ; (CH 2 ) p O(CH 2 ) q C(═O)OR 7 ; (CH 2 ) p O(CH 2 ) q C(═O)NR 7 2 ; (CH 2 ) p NR 7 (CH 2 ) q C(═O)OR 7 ; or (CH 2 ) p NR 7 (CH 2 ) q C(═O)NR 7 2 ; R 5 is (C 1 -C 6 )alkyl; NR 7 C(═O)(C 1 -C 6 )alkyl; NR 7 C(═O)O(C 1 -C 6 )alkyl; NR 7 C(═O)NR 7 2 ; CH(R 6 )NR 7 2 ; CH(R 6 )NR 7 C(═O)(C 1 -C 6 )alkyl; or CH(R 6 )NR 7 C(═O)O(C 1 -C 6 )alkyl; R 6 is H, (C 1 -C 6 )alkyl; (C 2 -C 6 )alkylene-OR 7 ; (CH 2 ) q C(═O)OR 7 ; or (CH 2 ) q C(═O)NR 7 2 ; R 7 is independently selected at each occurrence from the group consisting of hydrogen and (C 1 -C 6 )alkyl; m is independently at each occurrence 1, 2, or 3; n is 0, 1, or 2; p is independently at each occurrence 2 or 3; and q is independently at each occurrence 1 or 2.