Patent ID: 8178727

Claim:
An inhibitor of Ki-Ras, ErbB2, c-Myc, or Cyclin D1 expression; a β-catenin-degrading agent; a p53 expression enhancer; an anti-cancer agent; or a carcinogenesis chemopreventive agent, which comprises an effective amount of a bis(arylmethylidene)-acetone compound having the Formula: (wherein R 44 is a hydrogen atom or OR 34 , R 33 and R 38 , which may be identical or different, are independently a member selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, an alkoxy group, a hydroxy-alkoxy group, an alkoxyalkoxy group, an alkoxyalkoxyalkoxy group, an alkynyloxy group, and an azido-alkoxy group, or R 33 may be taken together with the adjacent substituent OR 32 or OR 34 to form an alkylene-dioxy bridge, and/or R 38 may be taken together with the adjacent substituent OR 37 or OR 39 to form an alkylene-dioxy bridge, and R 32 , R 34 , R 37 or R 39 , which may be identical or different, are independently a member selected from the group consisting of a hydrogen atom, an alkyl group, an alkynyl group, an alkoxyalkyl group, an alkoxyalkoxyalkyl group and an azido-alkyl group, or may be taken together with the adjacent substituent R 33 or R 38 to form the aforementioned bridge, provided that (1) when R 44 is a hydrogen atom, R 32 =R 39 =an alkyl group, and R 33 =R 38 =an hydroxyl atom or an alkoxy group, and (2) a compound wherein: (a) R 44 is OR 34 , R 32 =R 39 =an alkyl group, and R 33 =R 38 =a member selected from a hydrogen atom and an alkoxy group, and (b) R 44 is OCH 3 , R 32 =R 37 =R 39 =CH 3 , and R 33 =R 38 ═OH is excluded.