Patent ID: 7078203

Claim:
An isolated polynucleotide comprising a nucleic acid encoding Regulator of Cullins 1 (ROC1), said nucleic acid selected from the group consisting of: (a) a nucleic acid consisting of the nucleotide sequence of SEQ ID NO:1; (b) a nucleic acid which encodes a protein that forms a complex with a cullin protein and/or has ubiquitin ligase activity, wherein said nucleic acid hybridizes to the complete complement of a nucleic acid consisting of the nucleotide sequence of SEQ ID NO:1 under stringent conditions defined by a wash of 50% Formamide, 5×Denhardt's solution, 0.5% SDS and 1×SSPE at 42° C.; (c) a nucleic acid which encodes a protein that forms a complex with a cullin protein and/or has ubiquitin ligase activity, wherein said nucleic acid has at least 95% sequence identity to the nucleotide sequence of SEQ ID NO:1; and (d) a nucleic acid that differs from the nucleic acid of (a) to (c) above due to the degeneracy of the genetic code.