Patent ID: 6962772

Claim:
A method for manufacturing 3-D high aspect-ratio microneedle array device, comprising steps of: a) providing a substrate, with a photoresist layer coated thereon; b) performing photolithography on said photoresist layer by using a gray-tone mask so as to form a patterned photoresist layer; c) performing high-selectivity etching on said patterned photoresist layer and said substrate by using inductively coupled plasma etching so as to transfer said pattern onto said substrate and form a mold-structure; d) applying a material on said mold-structure and forming a replicated molded-material structure; and e) de-molding said replicated molded-material structure from said mold-structure, wherein said replicated molded-material structure comprises: a plurality of microneedles, each having a channel passing through its entire thickness; wherein said plurality of microneedles exhibit an adjustable 3-D aspect ratio and have a variable bevel angle at an opening of each of said microneedles.