Patent ID: 7378437

Claim:
A method of treating type 2 diabetes comprising administering to a subject a compound or salt thereof of the following formula: A-(B) b0 -(D) c0 -NO 2 (I) wherein c0 is an integer and is 0 or 1; b0 is an integer and is 0 or 1; with the proviso that at least one between c0 and b0 is different from zero; A=R-T 1 -, wherein R-T 1 - is a radical or a precursor drug acetylsalicylic acid of formula R-T 1 -OH, wherein T 1 =(CO); and R is a remaining radical of acetylsalicylic acid; B=T B -X 2 -T BI -wherein T B =X, wherein X=O, S, N or NR 1C , wherein R 1C is H or a linear or branched alkyl having from 1 to 5 carbon atoms; T BI =(CO) or X, wherein X is as above defined; and X 2 is a radical of a compound of formula H-X 2 -H selected from the following compounds: hydroxyacids, selected from the group consisting of: gallic acid, ferulic acid, gentisic acid, citric acid, caffeic acid, p-cumaric acid and vanillic acid; D is a bivalent radical -T c -Y- wherein: when b0 is 1, T c =(CO) when T BI =X, or T c =X when T BI =(CO), wherein X is as above defined; when b0 is 0, T c =X wherein X is as above defined; Y is: Y p : wherein: nIX is an integer in the range 0-3; nIIX is an integer in the range 1-3; R TIX , R TIX′ , R TIIX , R TIIX′ , equal to or different from each other are H or linear or branched C 1 -C 4 alkyl, Y 3 is a saturated, unsaturated or aromatic heterocyclic ring containing one or two nitrogen atoms, having 6 atoms; Y 0 , which is selected from the group consisting of: an alkylenoxy group R′ wherein R′ is C 1 -C 20 linear or branched; or one of the following groups: wherein nf′ is an integer from 1 to 6; wherein R 1f =H, CH 3 and nf is an integer from 1 to 6; or Y Ar , which is selected from the group consisting of: wherein n3 is an integer from 0 to 3 and n3′ is an integer from 1 to 3; wherein n3 and n3′ have the above indicated meaning; and when b0=1 then c0=1 and Y is Y 0 ; or when b0=0 then c0=1 and Y is Y p or Y Ar .