Patent ID: 8557783

Claim:
A method to modulate wound healing processes in a subject, said method comprising the administration of a composition containing an effective amount of a phosphonate prodrug of a phosphonotetrahydropyran compound of a compound of Formula I, and an acceptable pharmaceutical carrier, wherein the phosphonate prodrug is a mono- or di-ester of the phosphonic acid functionality; and wherein n is an integer from 0 to 3, the —O(CH 2 ) n R group is in an axial or equatorial position, and R is lower alkyl, or optionally substituted heteroaryl or optionally substituted aryl wherein the substituent is selected from the group consisting of —Cl, —F, CF 3 , CH 3 , CH 2 CH 3 , —OCH 3 , —OCF 3 , —(CH 2 ) m CO 2 R 1 , —(CH 2 ) m OR 2 , —(CH 2 ) m CONHR 2 , —(CH 2 ) m NHR 2 , and —(CH 2 ) m CONR 2 R 3 , wherein m is an integer from 0 to 3; R 1 is selected from the group of consisting of H, alkyl and aryl; and R 2 and R 3 are independently selected from the group consisting of H, alkyl, aryl and acyl.