Patent ID: 8163694

Claim:
A method of treating a cartilage, bone, connective tissue, periodontal or dental tissue, neural tissue, sensory system tissue, liver, cardiac, blood vessel, renal, or skin disease or condition that is treatable with osteoinductive materials, in a patient suffering from at least one of said diseases or conditions, comprising administering to said patient an effective amount of an osteoinductive material comprising a matrix material and, adsorbed on inner and/or outer surfaces of this matrix material, morphogenetic protein(s), wherein said osteoinductive material is obtained by contacting the matrix material and the morphogenetic protein(s) under suitable conditions to keep the protein stable and dissolved in a solution, thereby allowing the matrix material to become evenly coated with the morphogenetic protein(s), wherein said suitable conditions are (a) using a buffer or solvent which is capable of maintaining a pH above 10.3 during the coating procedure, or (b) using a buffer or solvent which has an ionic concentration of 20 mmol/l or less and is capable of maintaining a pH below 5.2 during the coating procedure, or (c) using a buffer or solvent which has an ionic concentration of 100 mmol/l or less and is capable of maintaining a pH above 9.5 during the coating procedure, wherein said connective tissue is at least one of tendon and ligament.