Patent ID: 8338362

Claim:
A method for the treatment of viral infection controllable by inhibiting SRPK enzymatic activity in a subject in need thereof comprising administering to the subject an effective inhibitory amount of an aniline derivative represented by the following formula (I): or a pharmaceutically acceptable salt or hydrate thereof; wherein, R 1 represents a hydrogen atom, a C 1-6 alkyl group which may have a substituent, a C 2-6 alkenyl group which may have a substituent, a C 2-6 alkynyl group which may have a substituent, a C 6-10 aryl group which may have a substituent, a halogen atom, a nitro group, a cyano group, an azide group, a hydroxy group, a C 1-6 alkoxy group which may have a substituent, a C 1-6 alkylthio group which may have a substituent, a C 1-6 alkylsulfonyl group which may have a substituent, a carboxyl group, a formyl group, a C 1-6 alkoxycarbonyl group which may have a substituent, an acyl group, an acylamino group, or a sulfamoyl group; R 2 represents a hydrogen atom, a C 1-6 alkyl group which may have a substituent, or an aryl group which may have a substituent; R 3 represents a C 1-6 alkyl group which may have a substituent, a C 2-6 alkenyl group which may have a substituent, a C 6-10 aryl group which may have a substituent, a nitrogen-containing heterocycle which may have a substituent, or a condensed aromatic heterocycle which may have a substituent; R 4 represents a hydrogen atom or a halogen atom; Q represents —C(O)—, —C(S)—, —SO 2 —, —C(S)NHC(O)—, —C(O)NHC(O)—, or —C(O)NHC(S)—; W represents a hydrogen atom, a C 1-6 alkyl group which may have a substituent, a C 6-10 aryl group which may have a substituent, a halogen atom, a hydroxy group, a C 1-6 alkoxy group which may have a substituent, a C 1-6 alkylthio group which may have a substituent, a nitrogen-containing heterocycle which may have a substituent, a condensed aromatic heterocycle which may have a substituent, or a group represented by the following formula (II): wherein, R 5 and R 6 are the same or different and each represents a hydrogen atom, a C 1-6 alkyl group which may have a substituent, a nitrogen-containing heterocycle which may have a substituent, a condensed aromatic heterocycle which may have a substituent, an acyl group, or an acylamino group; the above R 5 and R 6 together with the adjacent nitrogen atom may form a heterocycle which may have a substituent, and the heterocycle may be a condensed aromatic heterocycle which may have a substituent; the above R 5 and R 6 may be a cycloalkylidene amino group which may have a substituent, or an aromatic condensed cycloalkylidene group which may have a substituent; wherein the SRPK is SRPK1 or SRPK2.