Patent ID: 8921561

Claim:
A one-pot process for the preparation of a compound having Formula (III′), the process comprising: (a) contacting a compound having Formula (I) with POCl 3 to form a compound having Formula (II); and (b) contacting the compound having Formula (II) with an asymmetric catalyst and a hydrogen donor comprising a formate ion to form a compound having Formula (III′) according to the following reaction scheme: wherein: R 1 , R 5 , and R 7 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, and —OR 111 ; R 2 , R 4 , and R 6 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, and —OR 211 ; R 3 is chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, and —OR 211 ; R 12 and R 13 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, and —OR 111 ; R 111 is chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 211 is chosen from hydrogen, hydrocarbyl, —C(O)R 212 , —O(O)C(R 212 ) 3 , —C(O)NHR 212 , and —SO 2 R 212 ; R 212 is chosen from hydrocarbyl and substituted hydrocarbyl; and the compound having Formula (II) is not isolated as a solid prior to step (b).