Patent ID: 8278357

Claim:
A method of modulating a voltage-dependent potassium channel, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound having a general Formula I: wherein: Z is an A-G(=K)—X—Y group, and wherein: A is alkyl or absent; G is C; K is selected from the group consisting of O and S; X is selected from the group consisting of O and NRb; and Y is selected from the group consisting of hydroxyalkyl and a polyalkylene glycol residue, R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl or aryl; each of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, amino and —NR 15 R 16 , or, alternatively, at least two of R 2 , R 3 , R 4 , R 5 and R 6 , of R 7 , R 8 , R 9 and R 10 form a five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring; R 15 and R 16 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl and sulfonyl, or, alternatively R 15 and R 16 form a five- or six-member heteroalicyclic ring; and Rb is selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl, wherein said modulating of said voltage-dependent potassium channel is for a treatment of a condition or disorder selected from the group consisting of epilepsy, and schizophrenia.