Patent ID: 8268891

Claim:
A method for inhibiting autotaxin activity through the reaction of autotaxin with at least one thiourea compound wherein said thiourea compound exhibits a molecular weight of at most 527, wherein said thiourea compound includes a terminal carboxylate group; wherein said thiourea compound meets all extended flexibility metrics of Lipinski's rules for biological distribution; and wherein said thiourea compound exhibits an autotaxin inhibition capability of at least 59% through a reduction in available reaction sites thereon to prevent autotaxin conversion of lysophosphatidyl choline to lysophosphatidic acid, wherein said autotaxin inhibition capability involves ligation of autotaxin active site metal ions through the thiourea functional group, as well as the simultaneous electrostatic interactions of said terminal carboxylate group with autotaxin constituent proteins.