Patent ID: 8198258

Claim:
A double-stranded RNA compound having the structure: 5′(N) x —Z3′(antisense strand) 3′Z′—(N′) y 5′(sense strand) wherein each of N and N′ is a ribonucleotide which may independently be modified or unmodified in its sugar residue; wherein each of (N) x and (N′) y is an oligomer in which each consecutive N or N′ is joined to the next N or N′ by a covalent bond; wherein each of x and y is an integer from 19 to 23; wherein each of Z and Z′ may be present or absent, but if present is 1-5 consecutive nucleotides covalently attached at the 3′ terminus of the strand in which it is present; and wherein the sequence of (N) x comprises a sequence selected from one of the following sequences: (a) UUCUUCAGGAACUUGGGGU; (SEQ ID NO: 23) (b) GGAACGGUUGAUGGAUUUG. (SEQ ID NO: 25)