Patent ID: 8084610

Claim:
A compound structured to be selectively sequestered in acidic areas of a tissue, comprising: (a) at least one advanced pH-switch which includes i) a non-aromatic ring selected from the group consisting of: a 4-membered ring, a 5-membered ring, and a 6-membered ring; ii) a single carboxylic acid linked directly to said non-aromatic ring; iii) said carboxylic acid is separated from any linked electron-withdrawing group by at least two carbons; iv) an H-bond acceptor having a pKa of less than 7, wherein said H-bond acceptor meets one of the following criteria: said H-bond acceptor is part of said non-aromatic ring, said H-bond acceptor is linked directly to said non-aromatic ring, or said H-bond acceptor is linked through a one-atom spacer to said non-aromatic ring; v) said H-bond acceptor in its non-ionic form cannot serve as an H-bond donor; vi) said carboxylic acid and said H-bond acceptor are positioned and oriented so that they can form an internal acid-specific H-bond; and, (b) at least one advanced cargo which includes i) a structure selected from the group consisting of: an alkene, a 5-membered aromatic ring, a 6-membered aromatic ring; and, ii) linked directly to said structure is a radiohalogen having a chemical form selected from: a vinyl halide; and, an aryl halide.