Patent ID: 7186715

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or steroisomer thereof, wherein G is N; A is C 1 –C 8 alkyl or C 3 –C 7 cycloalkyl; L and L 1 are independently: hydrogen or together oxo; T is: R is: when y is 1; N(R 8 ) 2 , NR 8 COR 8 , NR 8 CON(R 8 ), NR 8 C(O)OR 8 , NR 8 SO 2 R 8 or R is: when y is 0 or 1; heterocyclyl, provided that when y is 0, a heteroatom is not directly connected to oxygen or adjacent to a carbon that is connected to oxygen; and wherein the heterocyclyl having at least one nitrogen in the heterocyclic ring and is optionally substituted with one to five substituents independently selected from R 8 ; R 1 is independently: hydrogen, CONH(C 1 –C 8 alkyl), C 1 –C 8 alkyl, (D)phenyl, (D)C 3 –C 7 cycloalkyl or oxo, provided that oxo is not attached to the ring carbon adjacent to G; R 2 is independently: hydrogen, halo C 1 –C 8 alkyl, C 1 –C 8 alkylsulfonyl, (D)C 3 –C 7 cycloalkyl or C 1 –C 4 haloalkyl; R 3 is independently: aryl or thienyl; wherein aryl and thienyl are optionally substituted with one to three substituents selected from the group consisting of: cyano, halo, C 1 –C 8 alkyl, (D)C 3 –C 7 cycloalkyl, C 1 –C 4 alkoxy, C 1 –C 4 haloalkyl, benzyloxy, and C 1 –C 4 haloalkyloxy; R 4 is independently: hydrogen, C 1 –C 8 alkyl, C(O)R 8 , C(O)OR 8 , C 3 –C 7 cycloalkyl or (CH 2 ) n O(C 1 –C 8 alkyl), wherein n is 2–8; each R 8 is independently: hydrogen, phenyl C 1 –C 8 alkyl, C 1 –C 8 alkylsulfonyl, C(O)C 1 –C 8 alkyl, C(O)aryl, wherein aryl being phenyl or naphthyl, SO 2 -aryl, wherein aryl being phenyl or naphthyl, (D)C 3 –C 7 cycloalkyl or (CH 2 ) n C 1 –C 4 haloalkyl, wherein n is 1–8; each R 9 is independently: hydrogen, hydroxy, (D)cyano, halo, C 1 –C 8 alkyl, C 1 –C 8 alkoxy, C 3 –C 7 cycloalkyl, C 1 –C 4 haloalkyl, (D)C(O)R 8 , (D)OR 8 , (D)OCOR 8 , (D)NR 8 SO 2 R 8 , each R 10 is independently: hydrogen, (C 1 –C 8 )alkyl, C(O)C 1 –C 8 alkyl, aryl or C 3 –C 7 cycloalkyl; each R 11 is independently: hydrogen, C 1 –C 8 alkyl, (CH 2 ) n N(R 8 ) 2 , (CH 2 ) n NR 8 C(O)C 1 –C 4 alkyl, and (CH 2 ) n NR 8 SO 2 C 1 –C 4 alkyl, wherein n is 2–8; D is a bond or —(CH 2 ) n —; n is 0–8; p is 0–4; q is 0–1; y is 0–1.