Patent ID: 8633215

Claim:
A compound of Formula I: wherein: X is C 1 -C 9 alkylene, C 2 -C 9 alkenylene, or C 2 -C 9 alkynylene; Y is S or O; R 1 is halogen, hydroxy, NH 2 , C 1 -C 6 alkoxy, CN, or C 1 -C 6 perfluoroalkyl; R 2 , R 3 , and R 4 are each, independently, selected from hydrogen, C 1 -C 6 alkyl, halogen, hydroxy, NH 2 , CN, C 1 -C 6 perfluoroalkyl, CO 2 H, OR 8 , COOR 8 , and NHR 8 ; R 5 and R 6 are each, independently, selected from hydrogen, C 1 -C 6 alkyl, C 2 -C 4 alkenyl, C 3 -C 7 cycloalkyl, phenyl, and benzyl, wherein the alkyl, alkenyl and rings of the cycloalkyl, phenyl and benzyl groups are optionally substituted with one or more groups independently selected from hydroxy, C 1 -C 4 alkoxy, —CO 2 H, C 1 -C 6 alkoxycarbonyl, NH 2 , C 1 -C 6 mono- or dialkylamino, and halogen; or R 5 and R 6 together with the nitrogen to which they are attached form a saturated, partially unsaturated, or unsaturated 3 to 12 membered monocyclic or bicyclic heterocyclic ring optionally comprising from one to three additional ring heteroatoms independently selected from N, O, and S, the remaining ring atoms are carbon atoms; R 7 is hydrogen, halogen, hydroxy, NH 2 , C 1 -C 3 alkyl, C 1 -C 3 alkoxy or NO 2 ; R 8 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 3 -C 7 cycloalkyl wherein the alkyl, alkenyl, and rings of the cycloalkyl are optionally substituted with one or more groups independently selected from hydroxy, C 1 -C 4 alkoxy, —CO 2 H, C 1 -C 6 alkoxycarbonyl, NH 2 , C 1 -C 6 mono- or dialkylamino, and halogen; or a pharmaceutically acceptable salt or zwitterionic form thereof.