Patent ID: 7468210

Claim:
A method of forming a cross-linked coating on a medical device, comprising the steps of: (a) immersing the medical device in a first solution comprising an organic solvent and a multifunctional crosslinking agent selected from the group consisting of a bis-variant of polyethylene glycol or polyethylene oxide, and (b) immersing the medical device in a second solution wherein the second solution comprises an organic solvent and a cross-linkable biomolecule selected from the group consisting of chondroitin sulfate, heparan sulfate and heparin and rendered surface adsorbable by conjugation with a silyl moiety of formula I through R 3 wherein R 1 is an C 1-8 alkyl or C 6-32 aryl group, each R 2 is independently selected from the group consisting of C 1-8 alkyl and C 6-32 aryl, R 3 is N or O, and n is a number from 1 to 10.