Patent ID: 8501669

Claim:
A system for screening biomarkers in bodily fluids in the presence of stabilization agents, comprising a detection platform, comprising: a plurality of detection sites each capable of receiving a disease state diagnostic biomarker, comprising a biological molecule indicative of a disease state, one or more of a plurality of stabilization agents, wherein the one or more of the stabilizing agents is comprising citric acid sodium hydroxide (Fixanal® Buffer 6.0 (Sigma-Aldrich Co.)), acetic acid, aluminum hydroxide bentonite, aluminum sulfate hydrate, aluminum potassium sulfate dodecahydrate, benzoic acid, caffeine, and 3-tert-butyl-hydroxvanisole, or a combination thereof; and an indicator labeled detection agent; a detection device capable of determining a binding characteristic between the indicator labeled detection agent and the disease state diagnostic biomarker in the detection sites; a computer database capable of receiving a plurality of binding characteristics, the plurality of binding characteristics comprising at least one binding property of a diagnostic biomarker molecule to said indicator labeled detection agent; a processor operably coupled to the computer database and the detection device, the processor having been programmed to: determine the binding characteristic of the indicator labeled detection agent to the disease state diagnostic biomarker in each of the plurality of detection sites; compare the binding characteristic among each of the plurality of detection sites to order the level of effect of the one or more from a plurality of stabilizing agents assayed on the binding characteristic between the indicator labeled detection agent and the disease state diagnostic agent; generate a binding report using the compared binding characteristics; and select the most effective one of said plurality of stabilizing agents at an amount or concentration sufficient to completely or substantially prevent or reduce degradation or inactivation of the disease state biomarker.