Patent ID: 8465635

Claim:
A system for the electrochemical determination of the evolution of the concentration or activity of at least one proteolytic enzyme for detecting a deficiency or abnormal activity thereof in a small sample of bodily fluid, wherein the system comprises: (a) a plurality of assorted electrochemical sensors, each sensor having a shape of a tongue of small dimensions and carrying at least one reference electrode and one working electrode, and a measuring aperture intended to receive the sample of bodily fluid, and a specific reagent for a given proteolytic enzyme is immobilised on the one working electrode of each sensor, wherein the composition of the specific reagent includes at least one chemical substrate, wherein an end link of the chemical substrate can be cut by the proteolytic enzyme to release leaving groups, wherein each sensor of the plurality of assorted sensors includes a material mark corresponding to a specific enzyme; (b) a measuring apparatus including at least one connecting slot for receiving a sensor, and the measuring apparatus further includes an electronic circuit, powered by an energy source, that imposes, between the electrodes of the sensors, an electric current whose intensity or voltage may or may not be variable, and the electronic circuit is disposed to receive, in return, an electric signal representative of the release of the leaving groups; and (c) an electronic apparatus including software, the electronic apparatus processing a signal transmitted by the measuring apparatus to display on a display screen an indication representative of the release of the leaving groups as a function of time, and wherein each material mark comprises a raised portion located along a unique axis of the corresponding sensor and each connecting slot includes a notch complementary to the corresponding raised portion.