Patent ID: 7989430

Claim:
A compound of formula I: R 1 -L-R 2 —B (I) wherein: R 1 is a ring selected from phenyl, furyl, thienyl, pyridyl, pyrrolyl, cyclohexyl, cyclopentyl, pyranyl, 1,2-dihydro-2-oxo-1H-pyrid-3-yl, and 2-oxopyranyl; which ring is optionally substituted with one or more R a ; or R 1 -L- together are a group of the following formula: L is selected from —C(═O)—NH—S(═O) 2 —O—, —C(═O)—NH—S(═O) 2 —NH—, —C(═O)—C(R b ) 2 —S(═O) 2 —NH—, —C(R b ) 2 —NH—S(═O) 2 —O—, —C(═O)—C(R b ) 2 —P(═O)(OH)O—, —C(═O)—C(R b ) 2 —C(═O)—NH—, —CH═CH—S(═O) 2 —NH—, —C(═O)—C(═N 2 )—S(═O) 2 —NH—, —S(═O) 2 —C(R b ) 2 —S(═O) 2 —NH—, —S(═O)(═NH)—C(R b ) 2 —S(═O) 2 —NH—, —C(═O)—C(═O)—C(R b ) 2 —NH—, —C(═O)—C(═O)—C(═O)—NH—, —C(═O)—C(R b ) 2 —S(═O) 2 —NH—, —CH(OH)—C(R b ) 2 —P(═O)(OH)O—, —C(═O)—NH—C(═O)—NH—, —CH═CH—P(═O)(OH)O—, —CH═CH—C(═O)—NH—, —C(═O)—NH—, —C(═O)—NH—S(═O) 2 —CH 2 —, —S(═O) 2 —NH—C(═O)—NH—, —C(═O)—NH—NH—C(═O)—CH 2 —, —C(═O)—NH—O—C(═O)—CH 2 —, —S(═O) 2 —NH—S(═O) 2 —NH—, —C(═O)—CH═CH—C(═O)—NH—, R 2 has the following formula: wherein the bond represented by ------ is a single bond and each R c is independently hydrogen, hydroxy, fluoro, azido, (C 1 -C 12 )alkoxy, (C 1 -C 12 )alkanoyloxy, or amino; or the bond represented by ------ is a double bond and each R c is absent; B is: W is O or NH: X is —C(═O)— or —S(═O) 2 —; Y is —NH— or —O—; Z is O, —NH—, —CH 2 —CH 2 —, or CH 2 ; each R a is independently hydroxy, amino, halo, (C 1 -C 6 )alkanoyloxy, nitro, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, or (C 1 -C 6 )alkanoylthio; each R b is independently hydrogen, fluoro, or chloro; each R d is independently azido, hydrogen, halo, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio, (C 2 -C 6 )alkenyloxy, (C 1 -C 6 )alkenylthio, (C 2 -C 6 )alkynyloxy, (C 1 -C 6 )alkynylthio, aryl, aryl(C 1 -C 6 )alkyl, aryl(C 2 -C 6 )alkenyl, aryl(C 2 -C 6 )alkynyl, carboxy(C 1 -C 6 )alkyl, carboxy(C 1 -C 6 )alkenyl, or NR f R g ; wherein each R f and R g is independently hydrogen, aryl, aryloxy, or (C 1 -C 6 )alkyl; each R e is independently hydrogen, hydroxy, (C 1 -C 6 )alkylthio, or NR k R m ; wherein each R k and R m is independently hydrogen, (C 3 -C 6 )cycloalkyl aryl, or (C 1 -C 6 )alkyl; and each R n is independently hydrogen, halo, azido, or amino; or a salt thereof; excluding the compound 5′-O—(N-(2-Hydroxybenzoyl)sulfamoyl)-adenosine.