Patent ID: 7429615

Claim:
A method of treating ocular hypertension or glaucoma which comprises administering to a mammal having ocular hypertension or glaucoma a therapeutically effective amount of a compound represented by formula I: wherein the wavy segment represents an α or β bond, a dashed line represents the presence or absence of a bond, R is selected from the group consisting of CO 2 R 4 , CONR 4 2 , CH 2 OR 4 , CONR 4 SO 2 R 4 , and P(O)(OR 4 ); wherein R 4 is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is 0 or an integer of from 1 to 4, R 1 and R 2 are independently selected from the group consisting of hydrogen, hydroxyl, a lower alkyloxy radical having up to six carbon atoms, or a lower acyloxy radical having up to six carbon atoms, R 3 is selected from the group consisting of hydrogen, a lower alkyl radical having up to six carbon atoms and a lower acyl radical having up to six carbon atoms, W is ═O, Y is a covalent bond or is selected from the group consisting of CH 2 , O, S and N and Z is a cycloalkyl radical including from three to ten carbon atoms or an aromatic radical including a hydrocarbyl aromatic radical having from six to ten carbon atoms or a heterocyclic aromatic radical selected from benzo[b]thiophen-3-yl and 3-chlorobenzo[b]thiophen-2-yl; and pharmaceutically-acceptable salts and esters thereof.