Patent ID: 7365094

Claim:
A compound of the general formula (II) and salts and physiologically functional derivatives thereof, wherein A is a heteroaromatic 5-membered ring system containing one or more groups X selected from the group consisting of S, O, N, NR 4 , SO 2 and SO; D is O, S, SO 2 , NR 4 , or CH 2 ; Z 1 and Z 2 are independent from each other O, S, or NR 5 ; R 1 independently represents H, halogen, haloalkyl, haloalkyloxy —CO 2 R″, —SO 3 H, —OH, —CONR*R″, —CR″O, —SO 2 —NR*R″, —NO 2 , —SO 2 —R″, —SO—R*, —CN, alkoxy, alkylthio, aryl, —NR″—CO 2 —R′; —NR″—CO—R*, —NR″—SO 2 —R′, —O—CO—R*, —O—CO 2 —R*, —O—CO—NR*R″; cycloalkyl, alkylamino, hydroxyalkylamino, —SH, heteroaryl, or alkyl; R* independently represents H, alkyl, cycloalkyl, aminoalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R′ independently represents H, —CO 2 R″, —CONHR″, —CR″O, —SO 2 NR″, —NR″—CO-haloalkyl, —NO 2 , —NR″—SO 2 -haloalkyl, —NR″—SO 2 -alkyl, —SO 2 -alkyl, —NR″—CO-alkyl, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkyloxy, aryl, arylalkyl or heteroaryl; R″ independently represents hydrogen, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, heteroaryl or aminoalkyl; R 2 is H or OR 6 ; R 3 is H, alkyl, cycloalkyl, aryl, alkoxy, O-aryl; O-cycloalkyl, halogen, aminoalkyl, alkylamino, hydroxylamino, hydroxylalkyl, halo alkyloxy, heteroaryl, alkylthio, S-aryl; S-cycloalkyl, arylalkyl, or haloalkyl; R 4 is H, alkyl, cycloalkyl, aryl or heteroaryl; R 5 is H, OH, alkoxy, O-aryl, alkyl or aryl; R 6 is H, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, alkylaryl, alkoxyalkyl, acylmethyl, (acyloxy)alkyl, non-symmetrical (acyloxy)alkyldiester, or dialkyiphosphate; R 7 is H, OH, alkyl, aryl, alkoxy, O-aryl, cycloalkyl, or O-cycloalkyl; R 8 is R hydrogen, or alkyl; E is a monocyclic or polycyclic substituted or unsubstituted ring system which contains at least one aromatic ring and which may also contain one or more groups X selected form S, O, N, NR 4 , SO, or SO 2 ; Y is a phenyl substituted by one or more substituents R′; m is 0 or 1; n is 0 or 1; p is 0 or 1; q is 0 or 1; s is 0 to 2; and t is 0 to 3; with the proviso that the following compounds are excluded: compounds wherein ring A contains five atoms, Z′=Z 2 =O, and R 2 together with the nitrogen atom which is attached to R 8 forms a 5 membered heteroyclic ring with the proviso that R 2 is—[CH 2 ] 8 , R 8 is absent and s is 0; compounds wherein ring A contains three carbon atoms and two nitrogen atoms, Z 1 =Z 2 =O, and R 2 together with the nitrogen atom which is attached to R 8 form a 5 membered heteroyclic ring with the proviso that R 2 is —[CH 2 ] 8 , R 8 is absent and s is 0; 4-[4-(naphthalin-2-yl) thiazol-2-ylaminocarbonyl]-furan-3-carboxylic acid; and 5-[4-(naphthalin-2-yl) thiazol-2-ylaminocarbonyl]-2H-[1,2,3]-triazole-4-carboxylic acid.