Patent ID: 8318749

Claim:
A compound of formula I wherein R 1 is hydroxy or NR′R″; R′ and R″ are each independently hydrogen, lower alkyl, cycloalkyl, or together with the N-atom to which they are attached form a heteroalkyl ring; R 2 is hydrogen, lower alkyl, lower alkoxy, halogen, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cyano or S(O) 2 -lower alkyl; R 3 is, —(CH 2 ) m -aryl optionally substituted by halogen, or —(CH 2 ) m -cycloalkyl; R 4 and R 5 are each independently hydrogen, lower alkyl substituted by halogen, —(CR 2 ) m -aryl or —(CR 2 ) m -heteroaryl, wherein the aryl or heteroaryl is optionally substituted by one or more substituents selected from halogen, lower alkyl, lower alkyl substituted by halogen, cyano, hydroxy, NR′R″ and lower alkoxy substituted by halogen, —(CR 2 ) m -cycloalkyl optionally substituted by hydroxy or by aryl, a heteroalkyl ring optionally substituted by ═O or —(CR 2 ) m -aryl, or R 4 and R 5 together with the N-atom to which they are attached form a heterocyclic ring system optionally substituted by lower alkyl, aryl or halogen-substituted aryl, each R is independently hydrogen, lower alkyl or lower alkyl substituted by hydroxyl; n is 1 or 2; and m is 0, 1 or 2; or a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or a tautomeric form thereof.