Patent ID: 7652009

Claim:
A compound of Formula I R 1 —X—W—A—Y—R (I) wherein R is selected from substituted or unsubstituted phenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, H, —OH, alkylamino, substituted or unsubstituted alkyl, and substituted or unsubstituted alkenyl and substituted or unsubstituted alkynyl; wherein R 1 is wherein ring T is phenyl; wherein Z is CH; wherein R 10 is one or more substituents selected from C 1-6 -alkoxy, C 1-6 -haloalkoxy, C 1-6 -alkylamino-C 1-6 -alkoxy, aryl-C 1-6 -alkoxy, heterocyclyl-C 1-6 -alkoxy, cycloalkyl-C 1-6 -alkoxy, heterocyclyl-C 1-6 -(hydroxyalkoxy), cycloalkyl-C 1-6 -(hydroxyalkoxy), aryl-C 1-6 -(hydroxyalkoxy), C 1-6 -alkoxyalkoxy, aryloxy-C 1-6 -alkoxy, heterocyclyloxy-C 1-6 -alkoxy, cycloalkyloxy-C 1-6 -alkoxy, aryloxy, heterocyclyloxy, and cycloalkyloxy; wherein W is an substituted or unsubstituted phenyl; wherein A is an substituted or unsubstituted pyrimidine or pyridazine ring; wherein X is selected from O, S, NR 2 and CR 3 R 4 ; wherein Y is a direct bond; wherein R a is selected from H, alkyl, heterocyclyl, aryl, arylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, R 5 R 5 N—(C═O)—, and R 5 —(═O)—; wherein R a is optionally substituted; wherein R 2 is selected from H, alkyl, haloalkyl, aryl, heterocyclyl, arylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl, alkylthioalkyl, alkenyl, alkynyl and R 5 -carbonyl; wherein R 3 and R 4 is each independently selected from H, alkyl, aryl, heterocyclyl, arylalkyl, heterocyclylalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, R 6 and alkyl substituted with R 6 ; wherein R 5 is selected from H, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl, alkylthioalkyl, arylalkyl, heterocyclylalkyl, cycloalkylalkyl, aryl, heterocyclyl, alkenyl, alkynyl and cycloalkyl; wherein R 5a is selected from H, alkyl, haloalkyl, arylalkyl, heterocyclylalkyl, cycloalkylalkyl, aryl, heterocyclyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl, alkylthioalkyl, alkenyl, alkynyl and cycloalkyl; wherein R 6 is selected from cyano, —OR 2 , —SR 2 , halo, —SO 2 R 2 , —C(═O)R 2 , —SO 2 NR 2 R 5 , —NR 5 C(═O)OR 2 , —NR 5 C(═O)NR 5 R 2 , NR 5 C(═O)R 2 , CO 2 R 2 , C(═O)NR 2 R 5 and —NR 2 R 5 ; wherein R 6a is selected from cyano, —OR 2 , —SR 2 , halo, —SO 2 R 2 , —C(═O)R 2 , —SO 2 NR 2 R 5 , —NR 5 C(═O)OR 2 , —NR 5 C(═O)NR 5 R 2 , —NR 5 C(═O)R 2 , ——CO 2 R 2 , —C(═O)NR 2 R 5 and —NR 2 R 5 ; wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, and alkoxy moiety of any R, R 1 , R 2 , R 3 , R 4 , R 5 , and R a is optionally substituted with one or more groups selected from halo, R 6a , —NH 2 , —OR 5a , —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl; and pharmaceutically acceptable salts thereof.