Patent ID: 8071592

Claim:
This invention provides a compound of formula (I) or a pharmaceutically acceptable salt or N-oxide thereof: wherein: two of Z 1 , Z 2 , Z 3 and Z 4 are independently CR 1c or N and the remainder are independently CR 1c ; or Z 3 and Z 4 together represent S and one of Z 1 and Z 2 is CR 1c or N and the other is independently CR 1c ; R 1a , R 1b and R 1c are independently selected from hydrogen; halogen; cyano; (C 1-6 )alkyl; (C 1-6 )alkylthio; trifluoromethyl; trifluoromethoxy; carboxy; hydroxy optionally substituted with (C 1-6 )alkyl or (C 1-6 )alkoxy-substituted(C1-6)alkyl; (C 1-6 )alkoxy-substituted(C 1-6 )alkyl; hydroxy (C 1-6 )alkyl; an amino group optionally N-substituted by one or two (C 1-6 )alkyl, formyl, (C 1-6 )alkylcarbonyl or (C 1-6 )alkylsulphonyl groups; or aminocarbonyl wherein the amino group is optionally substituted by (C 1-4 )alkyl; or two of R 1a , R 1b and R 1c on adjacent carbon atoms may together form an ethylenedioxy group; R 2 is hydrogen, or (C 1-4 )alkyl, or together with R 6 forms Y as defined below; A is a group (i): in which: R 3 is as defined for R 1a , R 1b and R 1c or is oxo or aminomethyl and n is 1 or 2: or A is a group (ii) W 1 , W 2 and W 3 are CR 4 R 8 or W 2 and W 3 are CR 4 R 8 and W 1 represents a bond between W 3 and N; X is O, CR 4 R 8 , or NR 6 ; one R 4 is as defined for R 1a , R 1b and R 1c and the remainder and R 8 are hydrogen or one R 4 and R 8 are together oxo and the remainder are hydrogen; R 6 is hydrogen or (C 1-6 )alkyl; or together with R 2 forms Y; R 7 is hydrogen; halogen; hydroxy optionally substituted with (C 1-6 )alkyl; or (C 1-6 )alkyl; Y is CR 4 R 8 CH 2 ; CH 2 CR 4 R 8 ; (Câ•O); CR 4 R 8 ; CR 4 R 8 (Câ•O); or (Câ•O)CR 4 R 8 ; or when X is CR 4 R 8 , R 8 and R 7 together represent a bond; U is selected from CO, and CH 2 and R 5 is in which: Y 3 is CH 2 or O; and R 10 is independently selected from hydrogen, halogen, (C 1-6 )alkyl and (C 1-6 )alkoxy.