Patent ID: 7557190

Claim:
A humanized variant anti-EpCAM antibody variable domain relative to antibody 17-1A variable domain, wherein said 17-1A variable domain comprises a heavy chain, SEQ ID NO: 1, and a light chain SEQ ID NO: 105, and, wherein said variant comprises at least one modification selected from the group consisting of: a first variant heavy chain framework region, a second variant heavy chain framework region, a third variant heavy chain framework region, a first variant light chain framework region, a second variant light chain framework region, and a third variant light chain framework region, wherein said first variant heavy chain framework region consists of Q5V and R13Q relative to SEQ ID NO: 1, wherein said second variant heavy chain framework region consists of K38R, R40A and I48M relative to SEQ ID NO: 1, wherein said third variant heavy chain framework region consists of K63S, F64L, G66S, K67R, A68V, L70I and T71S relative to SEQ ID NO: 1, wherein said first variant light chain framework region consists of K9D, M11L, S12A, M13V and V15L relative to SEQ ID NO: 105, wherein said second variant light chain framework region consists of E41G and K45Q relative to SEQ ID NO: 105, and, wherein said third variant light chain framework region consists of S76N, V78L, Q79E, L83A, D85T and H87Y relative to SEQ ID NO: 105, wherein said variant anti-EpCAM antibody variable domain contains an increased human string content relative to antibody 17-1A variable domain.