Patent ID: 7544812

Claim:
A compound that is represented by the following structural formula: (a) R1 is optionally substituted, aryl-C 1-4 -alkyl; (b) R2 is C 1 -C 6 alkyl; (c) W is O or S; (d) X is an optionally substituted C 1 -C 5 alkylene linker wherein one carbon atom of the linker may optionally be replaced with O, NH, and S, and optionally two carbons together may form a double bond; (e) Y is selected from the group consisting of CH 2 , O, S, NH and a single bond; and (f) E is selected from the group consisting of C(R3)(R4)A, A, and a substituted or unsubstituted group selected from the group consisting of (CH 2 ) n COOR19; and wherein (i) n is 0, 1, 2 or 3; (ii) A is an functional group selected from the group consisting of carboxyl, C 1 -C 3 alkylnitrile, carboxamide, substituted or unsubstituted sulfonamide, substituted or unsubstituted acylsulfonamide, substituted or unsubstituted tetrazole, and substituted or unsubstituted isoxazole; (iii) R3 is selected from the group consisting of H, C 1 -C 5 alkyl, and C 1 -C 5 alkoxy, and (iv) R4 is selected from the group consisting of H, halo, and a substituted or unsubstituted group selected from C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 3 -C 6 cycloalkyl, aryl C 0 -C 4 alkyl, arylC 0 -C 2 alkoxy and phenyl; or R3 and R4 are combined to form a C 3 -C 8 cycloalkyl; (v) R19 is selected from the group consisting of hydrogen, optionally substituted arylmethyl and optionally substituted C1-C4alkyl; (g) R8 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, and halo; (h) R9 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, halo, substituted or unsubstituted aryl, substituted or unsubstituted aryl-C 1 -C 4 alkyl, substituted or unsubstituted heteroaryl, C 2 -C 6 alkenyl, and OR10; (i) R10 is independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl; (k) R22 is selected from the group consisting of hydrogen, and a substituted or unsubstituted group selected from the group consisting of C 1 -C 6 alkyl, aryl, C 1 -C 4 alkylaryl, and heteroaryl; and salts thereof.