Patent ID: 7189729

Claim:
A compound of formula I: in which: n is 0, 1, 2 or 3; Z is ═CH—; R 1 is selected from hydrogen and —NR 4 R 5 ; wherein R 4 is selected from hydrogen and C 1-6 alkyl; and R 5 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl, wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 5 can he optionally substituted by 1 to 3 radicals independently selected from cyano, nitro, halo, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy and —NR 6 R 7 ; wherein R 6 and R 7 are independently selected from hydrogen and R 1-6 alkyl; R 2 is selected from hydrogen and C 1-6 alkyl; R 3 is selected from halo, cyano, nitro, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, —XNR 8 R 8 , —XNR 8 R 9 , —XC(O)R 8 , —XNR 8 C(O)R 9 and —XC(O)NR 8 R 9 ; wherein X is a bond or C 1-4 alkylene, R 8 is selected from hydrogen and C 1-6 alkyl, and R 9 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-6 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 9 is optionally substituted by a radical selected from halo-substituted-C 1-6 alkyl, —XOR 8 , —XR 10 , —XS(O) 2 N(OR 8 ) 2 , —XS(O)N(XOR 8 ) 2 , —XSN(OR 8 ) 2 , —XSR 10 , —XS(O)R 10 and —XS(O) 2 R 10 ; wherein X is a bond or C 1-6 alkylene, R 8 is hydrogen or C 1-6 alkyl, and R 10 is a radical selected from C 3-8 heterocycloalkyl and C 5-10 heteroaryl; wherein any heterocycloalkyl or heteroaryl of R 10 is optionally substituted by 1 to 3 radicals independently selected from halo, cyano, nitro, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy; and any one ring carbon of R 10 is optionally replaced by —C(O)—; and wherein the phenyl rings A and B can have up to four —C═ groups replaced by —N═; or a pharmaceutically acceptable salt thereof.