Patent ID: 8273766

Claim:
A tetrahydroisoquinoline compound represented by the following formula (1): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 , which are the same or different, each represent —H, -halogen, C 1-6 alkyl which may be substituted, —OH, —O—C 1-6 alkyl, —SH, —S—C 1-6 alkyl, —COOH, —CO—C 1-6 alkyl, —CO—O—C 1-6 alkyl, —CO—NH—C 1-6 alkyl, —NO 2 , —NH 2 , —NH—C 1-6 alkyl, —N(C 1-6 alkyl) 2 , or —NH—CO—C 1-6 alkyl; R 5 represents C 1-6 alkyl which may be substituted, C 3-10 cycloalkyl which may be substituted, C 6-14 aryl which may be substituted, —C 1-6 alkylene-C 3-10 cycloalkyl which may be substituted, or —C 1-6 alkylene-C 6-14 aryl which may be substituted; R 6 represents —H, —C 1-6 alkyl which may be substituted, or —Y′-A′; X represents C 1-6 alkylene; Y and Y′, which are the same or different, each represent a single bond or C 1-6 alkylene; A and A′, which are the same or different, each represent C 6-14 aryl which may be substituted or 3- to 15-membered heterocyclic group which may be substituted; and n represents 0 or 1.