Patent ID: 8178546

Claim:
A compound of structural formula II: or a pharmaceutically acceptable salt thereof; wherein each n is 0, 1, or 2; each p is 0, 1, or 2; R 8 is naphthyl or heteroaryl wherein heteroaryl is selected from the group consisting of pyridyl, thienyl, furyl, pyrazolyl, thiazolyl, oxazolyl, imidazolyl, indolyl, benzothiophenyl, benzofuryl, and benzimidazolyl; in which naphthyl and heteroaryl are substituted with one to three substituents independently selected from R 3 , R 4 , and R 5 ; R 2 is methyl or cyclopropyl; R 3 , R 4 , and R 5 are each independently selected from the group consisting of hydrogen, formyl, C 1-6 alkyl, C 2-6 alkenyl, (CH 2 ) n -aryl, (CH 2 ) n -heteroaryl, (CH 2 ) n -heterocyclyl, (CH 2 ) n C 3-7 cycloalkyl, halogen, OR 7 , (CH 2 ) n N(R 7 ) 2 , cyano, (CH 2 ) n CO 2 R 7 , NO 2 , (CH 2 ) n NR 7 SO 2 R 6 , (CH 2 ) n SO 2 N(R 7 ) 2 , (CH 2 ) n S(O) p R 6 , (CH 2 ) n SO 2 OR 7 , (CH 2 ) n NR 7 C(O)N(R 7 ) 2 , (CH 2 ) n C(O)N(R 7 ) 2 , (CH 2 ) n NR 6 C(O)R 6 , (CH 2 ) n NR 6 CO 2 R 7 , O(CH 2 ) n C(O)N(R 7 ) 2 , CF 3 , CH 2 CF 3 , OCF 3 , OCHCF 2 , and OCH 2 CF 3 ; wherein aryl, heteroaryl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, trifluoromethyl, trifluoromethoxy, and C 1-4 alkoxy; and wherein any methylene (CH 2 ) carbon atom in R 3 , R 4 , and R 5 is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; or two substituents when on the same methylene (CH 2 ) carbon atom are taken together with the carbon atom to which they are attached to form a cyclopropyl group; each R 6 is independently selected from the group consisting of C 1-8 alkyl, (CH 2 ) n -aryl, (CH 2 ) n -heteroaryl, and (CH 2 ) n C 3-7 cycloalkyl; wherein alkyl and cycloalkyl are unsubstituted or substituted with one to five substituents independently selected from halogen, oxo, C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, amino; and aryl and heteroaryl are unsubstituted or substituted with one to three substituents independently selected from cyano, halogen, hydroxy, amino, carboxy, trifluoromethyl, trifluoromethoxy, C 1-4 alkyl, and C 1-4 alkoxy; or two R 6 groups together with the atom to which they are attached form a 5- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, and NC 1-4 alkyl; and each R 7 is hydrogen or R 6 .