Patent ID: 7550489

Claim:
A composition comprising: (A) a compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from: (1) aryl, and (2) aryl-C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a , and each aryl is optionally substituted with one to four substituents independently selected from R b ; R 2 is selected from: (1) aryl, and (2) aryl-C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a , and each aryl is optionally substituted with one to four substituents independently selected from R b ; R 3 is selected from: (1) hydrogen, and (2) C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a ; R 4 is selected from: (1) hydrogen, and (2) C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a ; R 5 is selected from pyridyloxy and C 1-8 alkyl substituted with pyridyloxy, wherein alkyl is optionally substituted with one to four substituents independently selected from R a , and pyridyl is unsubstituted or substituted with one to three substituents independently selected from R h ; each R a is independently selected from: (1) —OR d , (2) —NR c S(O) m R d , (3) halogen, (4) —SR d , (5) —S(O) m NR c R d , (6) —NR c R d , (7) —C(O)R d , (8) —CO 2 R d , (9) —CN, (10) —C(O)NR c R d , (11) —NR c C(O)R d , (12) —NR c C(O)OR d , (13) —NR c C(O)NR c R d , (14) —CF 3 , and (15) —OCF 3 ; each R b is independently selected from: (1) R a , (2) C 1-10 alkyl, (3) oxo, (4) aryl, and (5) arylC 1-4 alkyl; R c and R d are independently selected from: (1) hydrogen, (2) C 1-10 alkyl, (3) C 2-10 alkenyl, (4) cycloalkyl, (5) cycloalkyl-C 1-10 alkyl; (6) aryl, and (7) aryl-C 1-10 alkyl, each R c and R d may be unsubstituted or substituted with one to three substituents selected from R h ; each R h is independently selected from: (1) halogen, (2) C 1-10 alkyl, (3) —OC 1-4 alkyl, (4) —SC 1-4 alkyl, (5) —CN, (6) —CF 3 , and (7) —OCF 3 ; and m is selected from 1 and 2; and (B) a second therapeutic agent selected from the group consisting of: an anorectic agents; or a pharmaceutically acceptable salt thereof.