Patent ID: 8748465

Claim:
A method for lowering blood glucose in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of a compound of formula I wherein: R1 is H or (C 1 -C 6 )-alkyl; R6, R7, R8, R9 and R10 are, independently of one another, H, F, Cl, Br, CN, CF 3 , OH, OCF 3 , OCHF 2 , SCH 3 , SCF 3 , phenyl, O-phenyl, COOH, COO—(C 1 -C 6 )-alkyl, CO—(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, O—(C 1 -C 6 )-alkyl, OBn, SO 3 H, SO 2 NR3R4, NR3R4 or SO 2 —N-piperidinyl, wherein the alkyl and phenyl moieties are optionally substituted one or more times by R2, or two of the radicals R6, R7, R8, R9 and R10, in adjacent position on the phenyl ring may together form a radical —O—CH 2 —O—, —O—(CH 2 ) 2 —O— or —CH═CH—CH═CH—; m is 0, 1, 2 or 3; X is bond, (C 2 -C 10 )-alkylene, (C 3 -C 12 )-cycloalkyl, (C 1 -C 8 )-alkylene-(C 3 -C 12 )-cycloalkyl-(C 1 -C 8 )-alkylene, (C 1 -C 8 )-alkylene-(C 3 -C 12 )-cycloalkyl, (C 3 -C 12 )-cycloalkyl-(C 1 -C 8 )-alkylene, (C 2 -C 8 )-alkenylene-(C 3 -C 12 )-cycloalkyl-(C 1 -C 8 )-alkylene, (C 1 -C 8 )-alkylene-(C 3 -C 12 )-cycloalkyl-(C 2 -C 8 )-alkenylene, (C 2 -C 8 )-alkenylene-(C 3 -C 12 )-cycloalkyl, (C 3 -C 12 )-cycloalkyl-(C 2 -C 8 )-alkenylene, (C 2 -C 10 )-alkenylene or (C 2 -C 10 )-alkynylene, wherein the alkylene, cycloalkyl, alkenylene and alkynylene moieties are optionally substituted one or more times by R5; R2 is OH, F, Cl, Br, CN, OCH 3 , OCF 3 , CH 3 , CF 3 , (C 1 -C 6 )-alkyl or O—(C 1 -C 6 )-alkyl, wherein the alkyl moiety is optionally substituted one or more times by OH, F, Cl, Br or CN; R3 and R4 are, independently of one another, H or (C 1 -C 6 )-alkyl, wherein the alkyl is optionally substituted one or more times by OH, F, Cl or Br; and R5 is NH 2 , NH(C 1 -C 4 )-alkyl, N[(C 1 -C 4 )-alkyl] 2 , F, Cl, Br, CN, OH, O—(C 1 -C 6 )-alkyl, (C 1 - 6 )-alkyl, (C 2 -C 6 )-alkenyl or (C 2 -C 6 )-alkynyl, or a physiologically tolerated salt thereof.