Patent ID: 7659424

Claim:
A method for producing enantioselectively allylated N-acylhydrazine represented by the following general formula (3): wherein R 0 represents an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or —COOR 1 (where R 1 represents a hydrocarbon group); R 2 represents an acyl group; R 3 and R 4 each represent a hydrogen atom, or one of R 3 and R 4 represents a hydrogen atom and the other represents a hydrocarbon group; R 5 and R 6 each independently represent a hydrogen atom or a hydrocarbon group; and R 4 and R 6 may together form an alkylene ring or a heterocycle, the method characterized by reacting, in the presence of chiral phosphine oxide, N-acylhydrazone represented by the following general formula (1): wherein R 0 and R 2 are as defined above, with an allylating reagent represented by the following general formula (2): wherein R 3 , R 4 , R 5 , and R 6 are as defined above; R 4 and R 6 may together form an alkylene ring or a heterocycle; and three Xs each represent a chlorine atom or a bromine atom, or two of the three Xs each represent a chlorine atom or a bromine atom and the other one represents an alkyl group.