Patent ID: 8420856

Claim:
A process for preparation of Teriflunomide (I) comprising steps of: (i) condensing ethylacetoacetate (II) with 4-trifluoromethyl aniline (III) in a solvent to give 3-oxo-N-(4-trifluoromethylphenyl)butanamide (IV); (ii) brominating 3-oxo-N-(4-trifluoromethylphenyl)butanamide (IV) with brominating agent optionally in presence of a solvent to give 2-bromo-3-oxo-N-[4-(trifluoromethyl)phenyl]butanamide (V); (iii) reacting 2-bromo-3-oxo-N-[4-(trifluoromethyl)phenyl]butanamide (V) with alkali cyanide in the presence of a solvent to give Teriflunomide (I).