Patent ID: 6887877

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein, M is A 1 is a bond; A is COOH; R 1 is benzyl, thiophene, CH 2 -thiophene, CH 2 -imidazole, or CH 2 -cyclohexyl which in each case is unsubstituted or substituted by at least one substituent chosen from halogen, OH or benzyl; R 2 is H or methyl; R 3 is 2,4-dichlorophenyl, 4-methoxy-2,3,6-trimethylphenyl, 2-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 4-chloro-2-iodo-phenyl, 2,4-dimethylphenyl, 4-chloro-2-methylphenyl, 4-chloro-2-bromo-phenyl, 4-chloro-2-ethylphenyl or 4-chloro-2-vinyl-phenyl; Y is â€”CH 2 â€”; Z is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-14 aryl, or C 3-10 heterocycle; R 4 is H, halogen, CN, NO 2 , C 1-6 alkyl, C 6-12 aryl, C 3-10 heterocycle, C 6-12 aralkyl C 3-10 heteroaralkyl, NR 5 R 5 , SO 2 CH 3 , Oâ€”C 1-6 alkyl, Oâ€”C 6-12 aryl, Oâ€”C 6-12 aralkyl, or COR 7 , R 5 is in each case independently H or C 1-6 alkyl, and R 7 is C 6-12 aryl or C 3-10 heterocycle.