Patent ID: 7148252

Claim:
A method for treating a glioma, comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1, 2, 3 or 4; p is 0, 1 or 2; R 1 is an unsubstituted or substituted C 6-12 aryl, C 7-12 arylalkyl, C 3-12 heterocycle or C 4-16 heterocyclealkyl; R 2 is NR a R b wherein R a and R b are independently hydrogen, C 1-8 alkyl, C 6-12 aryl, or heterocycle, and wherein R a and R b are optionally substituted with up to three substituents independently selected from C 1-6 alkyl, halogen, C 1-6 alkoxy, hydroxy and carboxyl; or R 2 is a heterocyclic ring of the following structure: wherein m 1 and m 2 are independently 0, 1 or 2, and both of m 1 and m 2 are not 0, A is CH 2 , O, S or NH, Z represents 0, 1, 2 or 3 heterocyclic ring substituents selected from halogen, C 1-8 alkyl, C 6-12 aryl, C 7-12 arylalky, C 3-12 heterocycle, or C 4-16 heterocyclealkyl, and wherein any hydrogen atom on the heterocyclic ring may, taken together with a hydrogen atom on an adjacent atom of the heterocylic ring, form a double bond; R 3 is hydrogen, R 4 , C(═O)R 4 , C(═O)OR 4 , CONHR 4 , CONR 4 R 5 , or SO 2 NR 5 R 5 ; R 4 and R 5 are independently C 1-8 alkyl, C 6-12 aryl, C 7-12 aralkyl, or a five- or six-membered heterocycle containing up to two heteroatoms selected from O, NR 6 and S(O) q , wherein each of the above groups are optionally substituted with one to three substituents independently selected from R 7 and q is 0, 1 or 2; R 6 is hydrogen or C 1-4 alkyl; and R 7 is hydrogen, halogen, hydroxy, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 acyloxy, C 1-4 thio, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, (hydroxy)C 1-4 alkyl, C 6-12 aryl, C 7-12 aralkyl, COOH, CN, CONHOR 8 , SO 2 NHR 8 , NH 2 , C 1-4 alkylamino, C 1-4 dialkylamino, NHSO 2 R 8 , NO 2 , or a five- or six-membered heterocycle, where each occurrence of R 8 is independently C 1-6 alkyl.