Patent ID: 8329715

Claim:
A method of treating asthma comprising administering to a human a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: A 1 is O or S; A 2 is O or S; U is N; V is C—(CH 2 ) v R V ; W is C—(CH 2 ) w R W ; X is C—(CH 2 ) x R X ; Y is C—(CH 2 ) y R Y ; Z is C—(CH 2 ) z R Z ; R 1 is —(CH 2 ) q R Q ; R 2 is —(CH 2 ) s R S ; wherein each of q, s, w, x, y, and z individually is 0, 1, 2, 3, or 4; v is zero; R Q is selected from the group consisting of: alkyl, cycloalkyl, phenyl, benzyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, and —OR 8 , wherein the cycloalkyl is optionally substituted with one or more R c ; the phenyl and benzyl are each independently optionally substituted with one or more R a ; and the tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl and piperidinyl are each independently optionally substituted with one or more R hc ; R V is chloro or —OCH 3 ; each of R S , R W , R X , R Y , and R Z is independently selected from the group consisting of alkyl; alkenyl; alkynyl; aryl; aryl substituted with one or more R a ; azido; cyano; cycloalkyl; cycloalkyl substituted with one or more R c ; fused cycloalkylaryl substituted with one or more R f1 ; fused arylcycloalkyl substituted with one or more R f2 ; fused heterocyclyaryl substituted with one or more R f3 ; fused arylheterocyclyl substituted with one or more R f4 ; fused cycloalkylheteroaryl substituted with one or more R f5 ; fused heteroarylcycloalkyl substituted with one or more R f6 ; fused heterocyclylheteroaryl substituted with one or more R f7 ; halogen; haloalkyl; heterocyclyl; heterocyclyl substituted with one or more R hc ; heteroaryl; heteroaryl substituted with one or more R ha ; hydrogen; —NR 3 R 4 ; —C(O)NR 3 R 4 ; —C(O)R 5 ; —C(O) 2 R 6 ; —S(O) j R 7 ; —OR 8 ; and nitro; wherein each of R 3 and R 4 is independently selected from the group consisting of H, acyl, alkyl, alkoxy, alkoxyalkyl, alkylsulfonyl, aryl, cycloalkyl, heterocyclyl and heteroaryl; j is 0, 1, or 2; each R 5 , R 6 , R 7 , and R 8 is independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; alkoxy; aryl; aryl substituted with one or more R a ; cycloalkyl; cycloalkyl substituted with one or more R c ; halogen; haloalkyl; heterocyclyl; heterocyclyl substituted with one or more R hc ; heteroaryl; and heteroaryl substituted with one or more R ha ; wherein each of R a , R c , R f1 , R f2 , R f3 , R f4 , R f5 , R f6 , R f7 , R hc and R ha is independently selected from the group consisting of acyl, alkyl, alkenyl, alkynyl, alkoxy, amide, amino, aryl, cyano, cycloalkyl, halogen, haloalkyl, haloalkoxy, heteroaryl, hydroxy, nitro, —C(O)OR 9 , —SO 2 R 10 , —SR 11 , —C(O)R 12 , —C(O)NR 13 , —NH—SO 2 —R 14 , —SO 2 —NR 15 R 16 , and —SO 2 —CH 2 —SO 2 —CH 3 ; and wherein each of R 9 , R 10 , R 11 , R 12 , R 13 R 14 , and R 16 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclyl, and heteroaryl.