Patent ID: 7244604

Claim:
An isolated nucleic acid molecule selected from the group: a) an isolated nucleic acid comprising SEQ ID NO: 1; b) a full complement of an isolated nucleic acid comprising SEQ ID NO: 1; c) a nucleic acid molecule that is hybridizable under high stringency conditions to a nucleic acid comprising SEQ ID NO: 1, wherein the high-stringency conditions comprise washes in a solution containing 0.1×SSC/0.1% SDS for 15 minutes at 68° C.; d) an isolated nucleic acid molecule encoding an HDAC polypeptide that has at least 95% sequence identity with SEQ ID NO: 2, or a full complement thereof, and e) an isolated nucleic acid molecule encoding an HDAC polypeptide that has at least 95% sequence identity with a histone deacetylase domain of SEQ ID NO: 2 encoded by exons 14–21 of SEQ ID NO: 1, or a full complement thereof, wherein the isolated nucleic acid molecule encodes a polypeptide that exhibits at least one activity selected from the group consisting of histone deacetylase activity, transcription repressor activity, and ability to deacetylate cellular substrates.