Patent ID: 8426645

Claim:
A process for producing a protected optically active fluoroamine of the formula [3], comprising: reacting an imine-protected optically active hydroxyamine of the formula [1], an oxazolidine-protected optically active hydroxyamine of the formula [2] or a mixture thereof with sulfuryl fluoride (SO 2 F 2 ) in the presence of a tertiary amine in which all of three ammonia hydrogen atoms have been replaced by alkyl groups and which has a carbon number of 7 to 18 where R 1 and R 2 each independently represent an alkyl group or an aromatic ring group; * represents an asymmetric carbon; the stereochemistry of the asymmetric carbon is maintained through the reacting; and the wavy line indicates in the formula (1) and in the formula (3) that the nitrogen-carbon group is in an E-configuration, a Z-configuration or a mixture thereof and indicates in the formula (2) that the substituent group R 1 is in a syn-configuration,an anti-configuration or a mixture thereof.