Patent ID: 7226925

Claim:
A compound of Formula (I): wherein nx is 2–4, R 0 and R 1 are each independently H or CH 3 ; R 2 is H, C 1 –C 4 -alkyl, 2-hydroxyethyl, 2-cyanoethyl or tetrahydropyran-2-yl, C 1 –C 4 -acyl or C 1 –C 4 -alkoxycarbonyl; R 3 –R 5 are each independently H, halogen, methyl or methoxy, provided that at least one of R 3 –R 5 is hydrogen; X, Y, and Z are each independently CH or N; A 1 is O, CH or CH 2 ; A 2 is O, CH or (CH 2 ) n2 , wherein n2 is an integer 0–2; the bond between A 1 and A 2 is a single or double bond; A 3 is (CH 2 ) n3 , wherein n3 an integer 0–10; A 4 is (CMe 2 ) n4 , wherein n4 is an integer 0–1; A 5 is N or O; A 6 and A 7 are each independently H, C 1 –C 4 -alkyl, amino-C 2 –C 4 -alkyl, N,N-di-C 1 –C 4 -alkylamino-C 2 –C 4 -alkyl, C 3 –C 6 -cycloalkyl; or when A 5 is nitrogen, A 6 and A 7 together with A 5 form a saturated heterocyclic ring; A 8 is (CH 2 ) n8 , wherein n8 is an integer 0–2; A 9 is H or CH 2 ; or pharmaceutically acceptable salts, hydrates, geometrical isomers, tautomers, optical isomers, and N-oxides thereof; and provided that when A 5 is N, then A 5 is substituted by only two of A 6 , A 7 and A 8 ; when A 5 is O, then A 5 is substituted by only one of A 6 , A 7 and A 8 ; and when A 9 is H, then A 8 is not a single bond between A 5 and A 9 .