Patent ID: 8618048

Claim:
Insulin derivative or its pharmaceutically acceptable salt containing two polypeptides forming chain A and chain B, characterised by being a new polipeptide of the formula 1: wherein R denotes group of formula Asn-R 2 , where R 2 denotes neutral L-amino acid; and R 1 denotes B31Lys-B32Arg, wherein B3Asn can be optionally replaced by B3Glu, or B31Arg, wherein amino acid sequence of chain A has been chosen from SEQ ID NO: 1-3, while amino acid sequence of chain B has been chosen from SEQ ID NO: 7, 9, and 10 in one of the following combinations: SEQ ID NO: 1 with SEQ ID NO: 7, SEQ ID NO: 1 with SEQ ID NO: 9, SEQ ID NO: 1 with SEQ ID NO: 10, SEQ ID NO: 2 with SEQ ID NO: 7, SEQ ID NO: 3 with SEQ ID NO: 7, SEQ ID NO: 3 with SEQ ID NO: 10, and wherein the new polypeptide of formula 1 is an analogue of recombined human insulin of isoelectric point 5-8.5.