Patent ID: 8809317

Claim:
A compound having the structure: and its pharmaceutically acceptable salts and hydrates, wherein: R 1 , R 2 , R 4 , R 5 , R 7 , and R 8 are selected independently from the group consisting of: hydrogen, halo, cyano, nitro, amino, carboxyl, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkycarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalky)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkycarbonyl, cycloheteroalkycarbonyl, aralkycarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalky)alkylcarbonylamino, dialkylamino, arylarmino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulonyl, heteroarylsuonyl, cycloalkylsulfonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycabhonyloxloxycarbonyl, heteroaralkyloxycarbony, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalky)alkyloxycarbony, iminoalkyl, iminocycloalky, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl; at least one of R 1 and R 8 is selected from the group consisting of: halo, nitro, cyano, carboxyl, formyl, and optionally substituted alkyl R 3 and R 6 are selected independently from the group consisting of: imino, and optionally substituted dialkylimino, diarylimino, di-heteroarylimino, alkylarylimino, alkylheteroarylimino, arylheteroarylimino, alkyloxyalkylamino, di-(alkyloxyalkyl)amino, aryloxyalkylamino, di-(aryloxyalkyl)amino, arylaminoalkylamino, di-(arylaminoalky)amino, heteroaryloxyalkylamino, di-(heteroaryloxyalkyl)amino, heteroarylaminoalkylamino, di-(heteroarylaminoalky)amino, and cycloalkylamino; and at least one of R 3 and R 6 is selected from the group consisting of: alkyloxyalkylamino, di-(alkyloxyalkyl)amino, aryloxyalkylamino, di-(aryloxyalkyl)amino, arylaminoalkylamino, di-(arylaminoalkyl)amino, heteroaryloxyalkylamino, di-(heteroaryloxyalky)amino, heteroarylaminoalkylamino, and di(heteroarylaminoalkylene)amino; wherein said optionally substituted is with a group which is hydrooxyl, nitro, amino, imino, cyano, halo, amidino, oxo, α-amidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, lower alkyl, haloloweralkyl, loweralkoxy, haloloweralkoxy, lower alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, heteroaralkylcarbonyl, aminoalkyl, or cyanoalkyl.