Patent ID: 8716284

Claim:
A method of treating depression, the method comprises administering a therapeutically effective amount of a compound of formula (I): wherein: R 1 and R 2 are each independently alkyl, cycloalkyl, ketocycloalkyl, heterocyclyl, aryl or heteroaryl, wherein each is optionally mono-, di-, or tri-substituted independently with alkyl, alkoxy, halogen, cyano, nitro, trifluoroalkyl, amino, alkylamino, dialkylamino, acyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-R 3 , —NHR 3 , —N(alkyl)R 3 , —C(O)NHR 3 , —C(O)N(alkyl)R 3 , —NHC(O)R 3 , —N(alkyl)C(O)R 3 , —OH or —OR 3 , wherein: R 3 is C 1 -C 6 alkyl or C 1 -C 6 cycloalkyl, which is optionally substituted with halogen, C 1 -C 3 alkoxy, OH, —CN, —NH 2 , —NH(C 1 -C 3 alkyl), —N(C 1 -C 3 alkyl) 2 , C 1 -C 3 alkylheterocyclyl, C 1 -C 3 alkylcarbamate, —C(O)NH(C 1 -C 3 alkyl), —C(O)N(C 1 -C 3 alkyl) 2 , —NHC(O)—C 1 -C 3 alkyl, —N(C 1 -C 3 alkyl)-C(O)—C 1 -C 3 alkyl, OH, or —O—C 1 -C 6 alkyl; with the proviso that the compound of formula (I) is not: N,N′-(1,3-adamantylene)bis(3-methoxy-benzamide); N,N′-(1,3-adamantylene)bis(4-ethoxy-benzamide); N,N′-(1,3-adamantylene)bis(4-methoxy-benzamide); N,N′-(1,3-adamantylene)bis(3,4,5-trimethoxybenzamide); N,N′-(1,3-adamantylene)bis(2-iodo-benzamide); N,N′-(1,3-adamantylene)bis-benzamide; N,N′-(1,3-adamantylene)bis(3-nitrobenzamide); and N,N′-(1,3-adamantylene)bis-(3-pyridinecarboxamide); or a pharmaceutically acceptable salt thereof to a mammal in need thereof.