Patent ID: 7157577

Claim:
A compound selected from the group consisting of Formula IV and VI: wherein R 10 –R 11 are independently selected from the group consisting of H, lower alkyl, phenyl substituted with halo, thiazolyl and cycloalkyl; R 12 is selected from the group consisting of —CH 2 —C(O)—X′—(CH 2 ) n -Z, —CH 2 -Z, where D is O or N—CH 3 ; X′ is NH, S, O or a bond; Z is a polar group selected from the group consisting of —C(O)OR 13 , —C(O)NR 13 R 14 , amino, alkylamino, dialkylamino, piperazinyl, pyrrolidinyl and morpholinyl, Z may be further substituted by —(CH 2 ) 0-1 -Z 1 , where Z 1 is a polar group selected from the group consisting of —C(O)OR 13 , —C(O)NR 13 R 14 , amino, alkylamino, dialkylamino, hydroxy, piperazinyl, pyrrolidinyl and morpholinyl; when Z is further substituted, R13 is not present; R13 is lower alkyl; R14 is H or lower alkyl; n is 0–3; and Alk is lower alkyl of 1–4 carbons; and pharmaceutically acceptable salts thereof.