Patent ID: 8623837

Claim:
A method of treating a hyperproliferative disorder in a subject in need thereof comprising administering a pharmaceutical composition comprising: (1) a DNA plasmid that encodes an anti-proliferative molecule selected from the group consisting of interleukin-2, interleukin-4, interleukin-7, IL-15, interferon-α, interferon-β, interferon-γ, colony stimulating factor, granulocyte-macrophage colony stimulating factor, anti-proliferative anti-angiogenic agents, TNF-α, eNOS, iNOS, IP10, p16, thymidine kinase, p53, Fas-ligand, anti-proliferative bacterial antigens, anti-proliferative viral antigens, anti-proliferative tumor antigens and any combination thereof; and (2) a lipopolymer, wherein the lipopolymer comprises a polyethylenimine backbone, wherein cholesterol and polyethylene glycol are each covalently linked to the polyethylenimine backbone; to the subject, wherein the anti-proliferative molecule is expressed in the subject such that a hyperproliferative disorder is treated.