Patent ID: 8404711

Claim:
A method of treating Alzheimer's disease or a cognitive disorder in a patient, the method comprising administering to the patient in need thereof a combination of a 5-HT 4 receptor agonist compound wherein the 5-HT 4 receptor agonist compound is 1-isopropyl-2-oxo-1,2- dihydroquinoline -3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl- methyl -amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a pharmaceutically acceptable salt thereof and donepezil hydrochloride, wherein the 5-HT 4 receptor agonist compound and the donepezil hydrochloride are each administered at a dose that is subefficacious for treating Alzheimer's disease or a cognitive disorder when administered alone.