Patent ID: 8822456

Claim:
A compound of Formula I, Wherein R 1 is hydrogen or methyl, wherein said methyl is optionally substituted with one to three substituents independently selected from halogen or methoxy; R 2 is C 1-6 alkyl, —(C(R 5 ) 2 ) m —(C 3-6 cycloalkyl), —(C(R 5 ) 2 ) m —(C 6-10 aryl), —(C(R 5 ) 2 ) m -(5- to 10-membered heteroaryl) or —(C(R 5 ) 2 ) t —OR 6 ; wherein said alkyl, cycloalkyl, aryl or heteroaryl moieties are optionally substituted with one to three substituents independently selected from halogen, C 1-6 alkyl, —CH 2 F, —CHF 2 , —CF 3 , —CN or —OR 7 ; R 3 is —(C(R 5 ) 2 ) m —(CN) or —(C(R 5 ) 2 ) n —(NHR 7 ); R 4 is independently selected from halogen, C 1-6 alkyl or C 1-6 alkoxy; wherein said alkyl or alkoxy is optionally substituted with one to three fluoro; R 5 at each occurrence is independently selected from hydrogen or C 1-3 alkyl, wherein said alkyl is optionally substituted with one to three halogen; R 6 is hydrogen, C 1-6 alkyl or —(C(R 5 ) 2 ) n —(C 6-10 aryl), wherein said alkyl and aryl are optionally substituted with one to three substituents independently selected from halogen, C 1-3 alkyl, —CH 2 F, —CHF 2 , —CF 3 , —CN or —OH; R 7 for each occurrence is hydrogen or C 1-6 alkyl, wherein said alkyl is optionally substituted with one to three substituents independently selected from halogen or C 1-6 alkoxy; m at each occurrence is independently 0, 1 or 2; n at each occurrence is independently is 1 or 2; t is 1 or 2; and x is 0, 1, 2 or 3; or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.