Patent ID: 8580713

Claim:
A method of detecting the type of mature B-cell neoplasm present in a sample, said method comprising: (a) providing a microarray, said microarray comprising a substrate with a plurality of distinct genomic regions and a backbone probe set that covers the entire human chromosomal complement arrayed thereon, wherein the backbone probe set covers the entire chromosomal complement at a resolution with an average density of approximately 1 Mbp, wherein each of the distinct genomic regions is individually capable of hybridizing to material present in said sample, wherein the genomic regions arrayed on the substrate are regions, wherein an alteration therein is correlated to one or more types of mature B-cell neoplasm, wherein the plurality of distinct genomic regions is all of the human genomic regions set forth in Table 6 and wherein the distinct genomic regions are between 0.3 to 21.3 Mbp in size and are represented on the microarray at a resolution with an average density of about 35 kbp; (b) providing the sample with labeled sample genetic material therein and labeled reference genetic material; (c) hybridizing the labeled sample genetic material and the labeled reference genetic material with the genomic regions and the backbone probe set arrayed on the substrate; (d) analyzing the hybridization pattern of the labeled sample genetic material to the genomic regions relative to the hybridization pattern of the reference genetic material to the genomic regions to detect the presence of alterations in the genetic material from the sample; and (e) correlating any detected alterations to the type of mature B-cell neoplasm associated with the alteration.