Patent ID: 8574592

Claim:
An immunogenic composition comprising (a) a recombinant influenza virus H5 hemagglutinin (HA) molecule, wherein said recombinant H5 HA molecule: (i) comprises one or more amino acid sequence changes as compared to a naturally occurring HA molecule that comprises an amino acid other than asparagine at an amino acid position corresponding to amino acid position 223 in H5 HA; (ii) comprises an asparagine at an amino acid position corresponding to amino acid position 223 in H5 HA; (iii) has an increased reactivity with antisera derived from an animal exposed to an H5 influenza virus or an H5 influenza vaccine as compared to said naturally occurring HA molecule; and (iv) is not A/HK/213/03 HA molecule, and (b) a carrier.