Patent ID: 8410310

Claim:
A method of treating or preventing blood loss, said method comprising administering to a subject in need thereof a compound of the formula (I) or a salt thereof, wherein R 1 is optionally present one or more times and each R 1 is, independently, hydrogen or COOR 5 ; R 2 is an optionally substituted ring system wherein said ring system is an aromatic or nonaromatic cyclic or bicyclic system comprising 5-13 carbon atoms; R 3 is an optionally substituted ring system wherein said ring system is selected from (i) an aromatic cyclic system comprising 5-6 carbon atoms, and (ii) an aromatic heterocycle comprising 3-5 carbon atoms and 1-2 nitrogen atoms, a nitrogen oxide, oxygen atom, or sulfur atom; R 4 is optionally present one or more times and each R 4 is, independently, hydrogen or a halogen; R 5 is hydrogen, a branched or linear lower alkyl group comprising 1-6 carbon atoms, a branched or linear aminoalkyl residue comprising 1-6 carbon atoms, a halogen or pseudohalogen residue, or a polyethylene glycol residue of the formula (II) or (III): CH 3 —O—(CH 2 —CH 2 —O—) n —CH 2 —CH 2 —(C═O)—NH—CH 2 — (II) CH 3 —O—(CH 2 —CH 2 —O—) n —CH 2 —CH 2 —NH—(C═O)—CH 2 —CH 2 —(C═O)—NH—CH 2 — (III) wherein said polyethylene glycol residue has a molecular weight of from 750 Da to 10,000 Da, and n is an integer from 25 to 250; o=1, 2 or 3; p=0, 1, 2, 3 or 4; i=0 or 1.