Patent ID: 7578954

Claim:
A method for constructing a microstructure, said method comprising: (a) providing a substrate of a first material, said substrate having a first substantially planar surface and a second substantially planar surface opposite said first surface, said substrate having a plurality of openings in the form of through-holes formed between said first and second surfaces; and then (b) pressing against the first surface of said substrate of material with an object having a predetermined shape to thereby form a plurality of permanent microelement protrusions in said first surface, said plurality of microelement protrusions being of at least one predetermined shape and size, each of said plurality of microelement protrusions having a base-shape that forms a perimeter along said first surface; wherein at least one of said plurality of microelement protrusions exhibit at least one of said plurality of openings within their said perimeter, and said microelement protrusions are suitable for penetrating the stratum corneum of human skin.