Patent ID: 7974789

Claim:
A method of selecting one or more polymorphisms from a genomic region of interest for use in genotyping, comprising the steps of: a. obtaining an SPC map from unphased diploid genotypes on a computer-readable medium by: i. obtaining the unphased diploid genotypes of a genomic region of interest from a plurality of subjects; ii. determining the major and minor metatypes found in said unphased diploid genotypes; iii. identifying one or more SPCs, wherein each SPC comprises a subset of polymorphisms from said metatypes wherein said polymorphisms of said subset coincide with each other polymorphism of said subset; and iv. assembling using a computer an SPC map of said genomic region of interest wherein said SPC map comprises a plurality of SPCs identified according to steps (i)-(iii), each SPC comprising a subset of polymorphisms from said genomic region wherein said polymorphisms if said subset co-segregates with each other polymorphism of said subset; b. selecting at least one cluster tag polymorphism which identifies a unique SPC in said SPC map; and c. selecting a sufficient number of cluster tag polymorphisms for use in a genotyping study of the genomic region of interest.