Patent ID: 7181349

Claim:
A method of determining whether a compound modulates insulin receptor activity, comprising comparing all or part of the structure of the compound to all or part of the fitted quaternary structure of an insulin receptor to determine how the compound interacts with the insulin receptor, the comparing step comprising: providing a computer program on a processor, the computer program including structural coordinates defining a ligand binding site conformation including at least one residue from monomer A in Table 1 and at least one residue from monomer B in Table 1, wherein the ligand binding site is defined by the approximate amino acid intersidechain distances listed in Table 1; said program displaying all or part of the fitted quaternary structure of the insulin receptor including the ligand binding site; comparing the structural coordinates of the compound to the structural coordinates of the ligand binding site and determining whether the compound fits spatially into the ligand binding site; wherein if the compound fits spatially into the ligand binding site, next determining whether the compound modulates the insulin receptor by determining if the compound agonizes the insulin receptor activity by performing an insulin receptor activity assay.