Patent ID: 6951945

Claim:
A compound comprising an amide of the formula: wherein, the * indicates an asymmetric carbon atom, R 1 and R 2 are independently hydrogen, halo, amino, hydroxyamino, cyano, nitro, lower alkyl, —OR 5 , —C(O)OR 6 , perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, lower alkoxy lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or sulfonamido; R 3 is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R 4 is an unsubstituted or mono-substituted thiazole or thiadiazole connected by a ring carbon atom to the amide group shown, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; said mono-substituted thiazole or thiadiazole being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, perfluoro-lower alkyl, oxo, —(CH 2 ) n —OR 7 , —(CH 2 ) n —C(O)—OR 7 , —(CH 2 )—C(O)—NH—R 7 , —C(O)C(O)—OR 7 , or —(CH 2 ) n —NHR 7 ; n is 0, 1, 2, 3 or 4; R 5 is hydrogen, lower alkyl, or perfluoro-lower alkyl; R 6 is lower alkyl; and R 7 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof.