Patent ID: 8809539

Claim:
A compound of formula (I): wherein represents a 1,2,4-oxadiazole group; X1 is a mono-, or bi-cyclic aryl; a monocyclic heteroaryl; a mono or bicyclic non-aryl heterocyclic; or a mono or bicyclic cycloalkyl comprising one or more unsaturations; R1 is selected from the group consisting of hydrogen, halo, perfluoro(c1-c6)alkyl, perfluoro(C1-C6)alkoxy, aryl, optionally substituted with halo, arylalkyl, optionally substituted with halo, alkylaryl, alkyl, optionally substituted with alkyl or (C3-C6) cycloalkyl, alkenyl, and cycloalkyl optionally comprising one or more unsaturations; Y1 represents a bond or Y1 is selected from a group consisting of —O—; —SO 2 —, and —C(=Q)-, wherein Q is O; each moiety R1-Y1, identical or different, represents a group that is attached to the cyclic ring structure X1 and m is an integer selected from 1 to 2, wherein m represents the number of positions on X1 substituted with a R1-Y1 moiety; Y2 represents a bond or Y2 is selected from a group consisting of —O—; —CH 2 —; —C(O)O—; —C(O)NH—; —S(O) q —, wherein q is 0, 1 or 2; and —C(=Q)-, wherein Q is O, S, N—(R′) 2 or N—OR′, wherein each R′ is independently selected from hydrogen, -alkyl, -alkenyl, -alkynyl, -alkoxy, -cycloalkyl or perfluoro(C1-C6)alkyl; R3 is hydrogen and p is 4; R4 and R5 are independently selected from the group consisting of hydrogen, methyl and —(C3-C6)cycloalkyl or R4 and R5 together with the C atom to which they are attached form a —(C3-C6)cycloalkyl group; R6 is selected from the group consisting of hydrogen, -alkyl, -alkenyl, -alkynyl and —(C3-C6)cycloalkyl; Z represents a —(C3-C6)cycloalkyl group, or R6 and Z form together with the N atom to which they are attached a 5 to 8 membered heterocyclic ring, wherein the alkyl is a C1-C6 linear or branched alkyl; the alkenyl is a C2-C6 linear or branched alkenyl, and aryl is mono- or bicyclic C6-C10; the —CO 2 R7 and —COR8 groups are attached to the same atom, wherein the —CO 2 R7 group represents a —CO 2 H group or an ester derivative thereof and the —COR8 group represents a —CO 2 H group or an ester or an amide derivative thereof, or enantiomers, diastereomers, mixtures and pharmaceutically acceptable salts, or hydrates or solvates thereof.