Patent ID: 8309069

Claim:
A stabilized and preserved aqueous pharmaceutical composition free of human serum albumin, comprising: interferon-β1a in an amount of about 10 μg/ml to about 800 μg/ml; acetate buffer present in an amount to maintain the pH of the composition within plus or minus 0.5 units of a specified pH, where the specified pH is about 3.0 to about 5.0; poloxamer 188 surfactant in an amount of about 0.01 mg/ml to about 10 mg/ml; methionine in an amount of about 0.01 to about 5.0 mg/ml; benzyl alcohol in an amount of about 0.1% to about 2.0%; and mannitol in an amount of 0.5 mg/ml to about 500 mg/ml.