Patent ID: 7462696

Claim:
A purified preparation of a human antibody comprising: a) a variable heavy chain comprising an amino acid sequence of SEQ ID NO: 100, wherein the variable heavy chain CDR3 region of SEQ ID NO: 100 is replaced by an amino acid sequence selected from the group consisting of SEQ ID NOS: 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, and 80, and the variable heavy chain CDR1 region of SEQ ID NO: 100 is optionally replaced by an amino acid sequence selected from the group consisting of SEQ ID NOS: 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, and 60; and b) a variable light chain comprising an amino acid sequence of SEQ ID NO: 94 or 95, wherein the variable light chain CDR3 region of SEO ID NO: 94 or 95 is replaced by an amino acid sequence selected from the group consisting of SEQ ID NOS: 81, 84, 85, 86, 87, 88, and 89, and the variable light chain CDR1 region of SEQ ID NO: 94 or 95 is optionally replaced by an amino acid sequence of SEQ ID NO: 82 or 83, wherein the antibody binds to a GEEDLP (SEQ ID NO: 118) repeat region within a MN protein's proteoglycan domain.