Patent ID: 8093353

Claim:
A composition comprising an isolated peptide of 10 to 29 amino acids in length, wherein the isolated peptide comprises the sequence: LRDIWDWICEVLSDFKTWLKA; (SEQ ID NO: 2) WLRDVWDWICTVLTDFKTWLQSKL; (SEQ ID NO: 5) WLRDVWDWVCTILTDFKNWLTSKL; (SEQ ID NO: 6) WLRDIWEWVLSILTDFKNWLSAKL; (SEQ ID NO: 7) WLRIIWDWVCSVVSDFKTWLSAKI; (SEQ ID NO: 8) WLRTIWDWVCSVLADFKAWLSAKI; (SEQ ID NO: 9) WLHDIWDWVCIVLSDFKTWLSAKI; (SEQ ID NO: 10) WLWDVWDWVLHVLSDFKTCLKAKF; (SEQ ID NO: 11) WLYDIVNWVCTVLADFKLWLGAKI; (SEQ ID NO: 12) WLRDIWDWVCTVLSDFRVWLKSKL; (SEQ ID NO: 13) SGSWLRDVWDWICTVLTDFKTWLQSKL; (SEQ ID NO: 14) LRDVWDWICTVLTDFKT; (SEQ ID NO: 463) LRDVWDWICT; (SEQ ID NO: 464) DVWDWICTVLTD; (SEQ ID NO: 465) and SWLRDVWDWIC; (SEQ ID NO: 466) LRDVWDWICVLTD; (SEQ ID NO: 471) SGSWLRDVWDWICTVATDFKTWLQSKL; (SEQ ID NO: 472) SGSWLRDVWDWICTVKTDFKTWLQSKL; (SEQ ID NO: 473) SGSWLRDVWDWICTVLADFKTWLQSKL; (SEQ ID NO: 474) SGSWLRDVWDWICTVLTAFKTWLQSKL; (SEQ ID NO: 475) SGSWLRDVWDWICTVLTDAKTWLQSKL; (SEQ ID NO: 476) SGSWLRDVWDWICTVLTDFKTALQSKL; (SEQ ID NO: 478) or SGSWLRDVWDWICTVLTDFKTWKQSKL, (SEQ ID NO: 479) wherein the peptide comprises a non-natural amino acid, wherein the peptide retains the ability to form an amphipathic helix, and wherein the isolated peptide inhibits infection by and/or replication of Hepatitis C Virus in vitro.