Patent ID: 8669284

Claim:
A soft gelatin capsule formulation of a bi-cyclic compound of formula (I): wherein, A is —CH 2 OH, —COCH 2 OH, —COOH or a functional derivative thereof; X 1 and X 2 are hydrogen, lower alkyl or halogen; V 1 and V 2 are carbon or oxygen; W 1 and W 2 are wherein R 4 and R 5 are hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy or hydroxy (lower) alkyl with the proviso that R 4 and R 5 are not hydroxy or lower alkoxy at the same time; Z is a carbon, oxygen, sulfur or nitrogen; R 1 is a saturated or unsaturated bivalent lower-medium aliphatic hydrocarbon residue which is unsubstituted or substituted with halogen, lower alkyl, hydroxy, oxo, aryl or heterocyclic group; R 2 is a saturated or unsaturated, lower or medium aliphatic hydrocarbon residue which is unsubstituted or substituted with halogen, oxo, hydroxy, lower alkyl, lower alkoxy, lower alkanoyloxy, lower cycloalkyl, lower cycloalkyloxy, aryl, aryloxy, heterocyclic group or heterocyclicoxy group; lower cycloalkyl; lower cycloalkyloxy; aryl, aryloxy, heterocyclic group or heterocyclicoxy group; R 3 is hydrogen, a lower alkyl, lower cycloalkyl, aryl or heterocyclic group, which comprises: a soft gelatin capsule shell comprising gelatin and a polyol selected from the group consisting of glycerin, propylene glycol and polyethylene glycol as a plasticizer, and a mixture comprising said bi-cyclic compound and glyceride, which is filled in the shell.