Patent ID: 8227472

Claim:
A compound of formula (I): wherein: R is hydrogen or an optionally further substituted group selected from: saturated or unsaturated, straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl and aryl; A is CH 2 or NH; Ar is an optionally substituted aryl, provided that when A is CH 2 and Ar is phenyl then R is other than 3-bromophenyl, 4-fluorophenyl, 4-tert-butylphenyl, cyclopropyl or 2-naphthyl and when A is CH 2 and Ar is thiophene then R is other than 3-bromophenyl, 4-fluorophenyl, 4-tert-butylphenyl, cyclopropyl, 2-naphthyl or benzyl; and isomers, tautomers, metabolites, prodrugs, carriers, N-oxides and pharmaceutically acceptable salts thereof.