Patent ID: 8558001

Claim:
A compound of Formula (Ia): wherein: R 1 is hydrogen, optionally substituted C 1-6 alkyl, —CH 2 OH, —CH 2 OP(O)(OR 20 )(OR 21 ), —C(O)R 22 , or —SO 2 R 23 ; R 2 is hydrogen, optionally substituted C 1-6 alkyl, C 3 -C 6 cycloalkyl, or halo; each of R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , R 11 , R 12 and R 13 is independently hydrogen, hydroxyl, —OP (O)(OR 20 )(OR 21 ), —CH 2 OH, —CH 2 OP(O)(OR 20 )(OR 21 ), optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkylene, optionally substituted C 2 -C 6 alkynyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 3 -C 6 cycloalkyl, aminocarbonyl, acyl, acylamino, —O—(C 1 to C 6 -alkyl)—O—(C 1 to C 6 -alkyl), cyano, halo, —SO 2 NR 24 R 25 ; or —NR 24 R 25 ; R 7 is hydrogen or optionally substituted C 1-6 alkyl; each of R 20 and R 21 is independently Na + , Li + , K + , hydrogen, C 1-6 alkyl; or R 20 and R 21 can be combined to represent a single divalent cation Zn 2+ , Ca 2+ , or Mg 2+ . each of R 22 and R 23 is independently optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted aryl, or —NR 24 R 25 ; and each of R 24 and R 25 is independently chosen from hydrogen or C 1-6 alkyl or when combined together with the nitrogen to which they are attached form a heterocycle; or a pharmaceutically acceptable salt, ester, single stereoisomer, mixture of stereoisomers, or tautomer thereof.