Patent ID: 6878698

Claim:
A method of treatment of COPD comprising the administration by inhalation of a pharmaceutical formulation comprising a compound of formula (I), wherein R 1 represents C 1-6 alkyl or C 1-6 haloalkyl; R 2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R 3 represents hydrogen, methyl (which may be in either the α or β configuration) or methylene; R 4 and R 5 are the same or different and each represents hydrogen or halogen; and represents a single or a double bond; or a salt or solvate thereof, together with a long-acting β 2 -adrenoreceptor agonist wherein said formulation has a therapeutically useful effect in the treatment of COPD over a period of 24 hours or more.