Patent ID: 8853215

Claim:
A compound represented by the formula wherein ring A is a benzene ring optionally substituted by 1 to 3 substituents selected from the group consisting of (a) a halogen atom, and (b) a C 1-6 alkyl group; ring B is a piperazine ring optionally substituted by 1 to 3 substituents selected from the group consisting of (a) a halogen atom, (b) a C 1-6 alkyl group optionally substituted by 1 to 3 halogen atoms, and (c) a C 1-6 alkoxy group optionally substituted by 1 to 3 halogen atoms; and R is (1) a C 1-10 alkyl group optionally substituted by 1 to 3 substituents selected from the group consisting of: (a) a carbamoyl group optionally mono- or di-substituted by (i) a C 1-6 alkylsulfonyl group, and (ii) a sulfamoyl group optionally substituted by a C 1-6 alkyl group optionally substituted by C 3-10 cycloalkyl, (b) a 5- or 6-membered aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from the group consisting of: (i) a carboxy group, and (ii) a C 1-6 alkyl group, (c) a 5- or 6-membered nonaromatic heterocyclic group optionally substituted by 1 to 3 carboxy groups, and (d) a carboxy group; (2) a C 6-14 aryl group optionally substituted by 1 to 3 substituents selected from the group consisting of: (a) a carboxy group, (b) a C 1-6 alkoxy group optionally substituted by 1 to 3 carboxy groups, and (c) a 5- or 6-membered nonaromatic heterocyclic group optionally substituted by 1 to 3 carboxy groups, and (d) a C 6-14 aryl group optionally substituted by a carboxy-C 1-6 alkyl group; (3) a 5- or 6-membered aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from the group consisting of: (a) a C 1-6 alkyl group optionally substituted by 1 to 3 carboxy groups, and (b) a C 1-6 alkoxy group optionally substituted by 1 to 3 carboxy groups; (4) an amino group optionally mono- or di-substituted by substituents selected from the group consisting of: (a) a C 6-14 aryl group optionally substituted by 1 to 3 carboxy-C 1-6 alkoxy groups, (b) a C 1-6 alkyl group optionally substituted by 1 to 3 carboxy groups, and (c) a 5- or 6-membered aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from the group consisting of: (i) a hydroxy group, and (ii) a carbamoyl group; (5) a carboxy group; and (6) a carbamoyl group optionally mono- or di-substituted by substituents selected from the group consisting of: (a) a C 1-6 alkyl group optionally substituted by 1 to 3 substituents selected from the group consisting of: (i) a C 6-14 aryl group optionally substituted by 1 to 3 substituents selected from the group consisting of: (A) a carboxy group, and (B) a carboxy-C 1-6 alkyl group, (ii) a carboxy group, and (iii) a C 1-6 alkyl-sulfonyl group, and (b) a 5- or 6-membered nonaromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from the group consisting of: (i) a carboxy group, (ii) a carboxy-carbonyl group, and (iii) a carboxy-C 1-6 alkoxy group, or a salt thereof.