Patent ID: 8759334

Claim:
A compound according to Formula Ia: wherein L 1 is a single bond, or CR a R b ; L 2 is a single bond, O, NR e or CR c R d ; each of R a , R b , R c , and R d is independently selected from H, and C 1-4 alkyl; or R a and R b together with the carbon to which they are attached may form a C 3-7 cycloalkyl; or R c and R d together with the carbon to which they are attached may form a C 3-7 cycloalkyl; R e is C 1-4 alkyl; Y is C 1-4 alkyl optionally substituted with one or more groups independently selected from fluoro, OH, and phenyl (optionally substituted with one or more groups independently selected from C 1-4 alkyl (optionally substituted with one or more halo), C 1-4 alkoxy, halo and cyano), or C 1-4 alkenyl comprising 1 double bond; each of Cy 1 and Cy 2 is independently C 6-10 aryl, or 5-10 membered heteroaryl; each R 1 is independently selected from halo, C 1-4 alkyl (optionally substituted with one or more halo), and C 1-4 alkoxy (optionally substituted with one or more halo); R 2 is: H, C 1-4 alkyl optionally substituted with one or more independently selected R 2a groups, C 3-7 cycloalkyl optionally substituted with one or more independently selected R 2a groups, R 2a is halo, C 1-6 alkoxy, OH, C(═O)R 4 , S(O) 2 R 4 , CN, NHC(═O)R 5 , NHSO 2 R 5 , 5-7 membered heterocycloalkyl (optionally substituted with one or more groups independently selected from C 1-4 alkyl, and oxo), or 5-6 membered heteroaryl (optionally substituted with one or more groups independently selected from halo, OH, C 1-4 alkoxy and C 1-4 alkyl); R 3 is selected from halo, C 1-6 alkyl (optionally substituted with one or more halo), C 1-6 alkoxy (optionally substituted with one or more halo, or phenyl), C 1-6 thioalkoxy, phenyl (optionally substituted with one or more groups independently selected from halo, C 1-4 alkyl (optionally substituted with one or more halo), C 1-4 alkoxy, C(═O)—C 1-4 alkoxy and CN); R 4 is —OH, —C 1-6 alkoxy, —N-linked 5-7 membered heterocycloalkyl (optionally substituted with one or more groups independently selected from C 1-6 alkyl, and oxo), —NR 4a R 4b , or —NHSO 2 R 4c ; Each of R 4a and R 4b is independently H, C 1-4 alkyl (optionally substituted with phenyl (optionally substituted with one or more groups independently selected from halo, CN, C 1-6 alkyl, and C 1-6 alkoxy)), or C 3-7 cycloalkyl; R 4c is phenyl, 5-6 membered heteroaryl, 5-6 membered heterocycloalkyl (optionally substituted with one or more C 1-4 alkyl) or C 1-4 alkyl (optionally substituted with one or more halo); R 5 is C 1-4 alkyl (optionally substituted with one or more halo) or phenyl; and the subscripts n and m are independently selected from 0, 1, and 2; or a pharmaceutically acceptable salt, or a solvate, or a solvate of the pharmaceutically acceptable salts.