Patent ID: 8431589

Claim:
A compound of formula I wherein X is ═CR 0 —; R 0 is hydrogen; R 2 is —SO 2 N(R 10 )R 11 ; each of R 1 and R 3 independently is hydrogen; hydroxy; C 1 -C 8 alkyl; C 2 -C 8 alkenyl; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkyl-C 1 -C 8 alkyl; hydroxyC 1 -C 8 alkyl; C 1 -C 8 alkoxyC 1 -C 8 alkyl; hydroxyC 1 -C 8 alkoxyC 1 -C 8 alkyl; arylC 1 -C 8 alkyl which optionally may be substituted on the ring by hydroxy, C 1 -C 8 alkoxy, carboxy or C 1 -C 8 alkoxycarbonyl; or each of R 1 and and R 3 , independently, is halogen; halo-C 1 -C 8 alkyl; C 1 -C 8 alkoxy; halo-C 1 -C 8 alkoxy; hydroxyC 1 -C 8 alkoxy; C 1 -C 8 alkoxyC 1 -C 8 alkoxy; aryl; arylC 1 -C 8 alkoxy; heteroaryl; heteroaryl-C 1 -C 4 alkyl; 5 to 10 membered heterocyclic ring; nitro; carboxy; C 2 -C 8 alkoxycarbonyl; C 2 -C 8 alkylcarbonyl; —N(C 1 -C 8 alkyl)C(O) C 1 -C 8 alkyl; —N(R 10 )R 11 ; —CON(R 10 )R 11 ; or —C 1 -C 4 -alkylene-SO 2 N(R 10 )R 11 ; wherein each of R 10 and R 11 independently is hydrogen; hydroxy; C 1 -C 8 alkyl; C 2 -C 8 alkenyl; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkyl-C 1 -C 8 alkyl; C 1 -C 8 alkoxyC 1 -C 8 alkyl; hydroxyC 1 -C 8 alkoxyC 1 -C 8 alkyl; hydroxyC 1 -C 8 alkyl; (C 1 -C 8 alkyl)-carbonyl; arylC 1 -C 8 alkyl which optionally may be substituted on the ring by hydroxy, C 1 -C 8 alkoxy, carboxy or C 2 -C 8 alkoxycarbonyl; or 5 to 10 membered heterocyclic ring; R 4 is hydrogen; R 5 is hydrogen; halogen; C 1-4 alkyl; or CF3; R 6 is hydrogen; each of R 7 , R 8 and R 9 is independently hydrogen; hydroxy; C 1 -C 8 alkyl; C 2 -C 8 alkenyl; halo-C 1 -C 8 alkyl; C 1 -C 8 alkoxy; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkylC 1 -C 8 alkyl; arylC 1 -C 8 alkyl; —Y—R 12 wherein Y is a direct bond or O and R 12 is a substituted or unsubstituted 5, 6 or 7 membered heterocyclic ring comprising 1, 2 or 3 heteroatoms selected from N, O and S; carboxy; (C 1 -C 8 alkoxy)-carbonyl; —N(C 1-8 alkyl)—CO—NR 10 R 11 ; —CONR 10 R 11 ; —N(R 10 )(R 11 ); —SO 2 N(R 10 )R 11 ; R 7 and R 8 or R 8 and R 9 , respectively form together with the carbon atoms to which they are attached, a 5 or 6 membered heteroaryl comprising 1, 2 or 3 heteroatoms selected from N, O and S; or a 5 or 6 membered carbocyclic ring; wherein any alkyl, alkoxy, alkenyl, cycloalkyl, heterocyclic ring, aryl or heteroaryl may be unsubstituted or substituted by one or more substituents selected from halogen; OH; C 1 -C 8 alkyl; C 1 -C 8 alkoxy; nitro; cyano; COOH; carbamoyl; C(NH 2 )═NOH; —N(R 10 )R 11 ; C 3 -C 6 cycloalkyl; 3 to 7 membered heterocyclic ring; phenyl; phenyl-C 1-4 alkyl; 5 or 6 membered heteroaryl; in free form or salt form.