Patent ID: 8383107

Claim:
An isolated antibody fragment comprising: a CDR1/H1 region sequence selected from the group consisting of VRTFSIYAMG (SEQ ID NO: 94), GFKITHYTMG (SEQ ID NO: 95), and VRTFSIYAIG (SEQ ID NO: 96); a CDR2/H2 region sequence selected from the group consisting of GINRSGDVTKYADFVKG (SEQ ID NO: 97) and RITWGGDNTFYSNSVKG (SEQ ID NO: 98); and a CDR3/H3 region sequence selected from the group consisting of TWAYDTVGALTSGYNF (SEQ ID NO: 99) and GSTSTATPLRVDY (SEQ ID NO: 100), wherein said antibody fragment selectively binds to an antigen on the surface of mammalian cells expressing blood-brain barrier antigens and transmigrates across a blood-brain barrier.