Patent ID: 6909001

Claim:
A method of making a tricyclic aminocyanopyridine compound, the method comprising: reacting a substituted benzaldehyde having the structure: with a tricarbonitrile having the structure: to form an aminocyanopyridine compound having the structure: wherein: Z is selected from the group consisting of —OH, —SH, and —NR a Y; R a is selected from the group consisting of alkyl, aryl, and heteroaryl; Y is a protecting group for nitrogen that is selected from the group consisting of benzyl, allyl, alkyl carbamates and benzyl carbamate; G is selected from the group consisting of oxygen, sulfur, and nitrogen; when G is oxygen, it is unsubstituted; when G is sulfur, it is either unsubstituted or is substituted with one or two oxo groups; when G is nitrogen, it is substituted with C 1 -C 4 alkyl; R b is selected from the group consisting of furyl and —NH—R 2 ; R 2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkylaryl, arylalkyl, alkoxyaryl, aminoalkyl, alkylaminoalkyl, arylaminoalkyl, alkoxyalkyl, alkylcarboxy, and carboxyalkyl; R 3 and R 4 are each independently selected from the group consisting of hydrogen, dicyanoalkyl, and substituted or unsubstituted heterocyclyl and cyclyl, where substituents, if any, comprise halo moieties; and R 5 , R 6 , R 7 and R 8 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, halo, alkyl, alkenyl, alkylyl, arylalkyl, alkylaryl, amino, alkylamino, arylamino, alkylaminoalkyl, carboxy, aminoalkoxy, alkylcarboxyalkyl, alkylamino, aminoalkyl, nitro, aryl, arylamino, alkenoxy, hydroxyalkoxy, alkoxyalkoxy, heterocyclylalkyl, heterocyclylalkoxy, carboxyalkoxy, alkylaminoalkoxy, alkylcarboxyalkoxy, pyrrolidylethoxy, hydroxyalkoxy, and alkylcarboxy, where R 6 and R 7 are such that they optionally join to form a six membered heterocyclic ring.