Patent ID: 6887960

Claim:
A process for preparing a bioadhesive composition comprising copolymer particles comprising: a) providing a reaction mixture comprising: i) from 60 weight % to 99 weight % based on weight of said copolymer particles, of at least one ethylenically unsaturated nonionic monomer and ii) from 40 weight % to 1 weight % based on weight of said copolymer particles, of at least one oligomer selected from the group of oligomers with formulas: wherein N is the residue of an ethylenically unsaturated carboxylic acid monomer and has the formula: wherein M is the residue of a second ethylenically unsaturated monomer and has the formula: wherein said N and M residues are randomly arranged in said oligomer; wherein m is the total number of M residues in said oligomer and is in t the range of 0 to 150; wherein n is the total number of N residues in said oligomer and is in the range of 2 to 300; wherein n is greater than or equal to m; wherein the sum of n and m is in the range of 2 to 300; wherein X is selected from the group consisting of â€”COOY and R; wherein R is selected from phenyl radicals, substituted phenyl radicals, â€”CONH 2 , â€”CONHRâ€², â€”CONRâ€²Râ€², â€”CN, â€”COORâ€², â€”OCORâ€², â€”Cl, and mixtures thereof, wherein Râ€² is an alkyl or alkoxyalkyl radical independently selected from the group consisting of branched, unbranched, or cyclic hydrocarbon radicals having 1 to 18 carbon atoms; wherein Y is independently selected from the group consisting of H, NH 4 , alkali metals and alkaline earth metals; and wherein each Z is independently selected from the group consisting of H and CH 3 , b) polymerizing said reaction mixture; and c) forming copolymer particles and d) adding a therapeutic substance.