Patent ID: 8575160

Claim:
A compound of Formula I: wherein: R 1 and R 2 are independently OH, C 2-7 alkenyloxy, C 2-7 alkoxy, C 6-10 aryl, aryl-C 2-7 alkenyl, C 2-7 alkenyl, C 3-8 cycloalkyl, C 2-7 alkynyl, C 1-7 cycloalkyl-C 2-7 alkynyl, heteroaryl, heteroaryl-C 1-7 alkyl, —CH 2 C(O)OH, —CH 2 C(O)O—C 1-7 alkyl, —CH 2 C(O)NH—C 6-10 aryl, —CH 2 C(O)NH-heteroaryl, —CH 2 C(O)-heterocyclyl, —CH 2 C(O)NH-heterocyclyl, —CH 2 C(O)NH—C 1-7 alkyl, —C(O)O—C 1-7 alkyl or —C(O)—C 1-7 alkyl; wherein aryl, heterocyclyl and heteroaryl are optionally substituted with one or more R 6 ; with the proviso that one of R 1 and R 2 is other than C 1-7 alkyl; or R 1 and R 2 form together ═O, ═N(OH) or ═N(O—C 1-7 alkyl); and R 3 and R 4 are independently selected from the group consisting of H, hydroxy, aryl-C 1-7 alkyl or halo; wherein aryl is optionally substituted with one or more R 8 ; and R 5 is H, halo, hydroxy or C 2-7 alkenyl; and R 6 and R 8 for each occurrence, is independently C 1-7 alkyl, C 3-7 cycloalkyl, CN, OH, NH 2 , C 1-7 alkylamino, di-(C 1-7 alkyl)amino, C 6-10 aryl, heteroaryl, C 1-7 alkoxy, halo, heterocyclyl, benzyloxy, halo-C 1-7 alkoxy, —OS(O) 2 —C 1-7 alkyl or —OS(O) 2 -halo C 1-7 alkyl; wherein C 8-10 aryl, heterocyclyl and heteroaryl are optionally substituted with one or more R 9 ; for each occurrence, R 7 is independently hydrogen, C 2-7 alkenyl, C 3-8 cycloalkyl, halo, nitro, cyano, NH 2 , haloC 1-7 alkyl, C 1-7 alkoxy, C 3-8 cycloalkoxy, C 8-10 aryloxy, C 8-10 aryl, heteroaryl, heteroaryl-C 1-7 alkyl, heterocyclyl, heterocyclyl-C 1-7 alkyl, C(O)OR 10 or N(R 11 R 12 ), wherein said alkyl, alkenyl, alkoxy, aryl, heterocyclyl and heteroaryl each are optionally substituted with one or more substituent independently selected from C 1-7 hydroxy, halo, halo C 1-7 alkyl, C 1-7 alkoxy, nitro, cyano, C 1-7 alkylamino and C 1-7 alkoxy-C 1-7 alkyl; R 9 for each occurrence, is independently C 1-7 alkyl, C 1-7 alkoxy, halo, haloC 1-7 alkyl, NH 2 , C 1-7 alkylamino, di-(C 1-7 alkyl)amino, haloC 1-7 alkoxy, CN, OH, C(O)O—C 1-7 alkyl, C(O)O-haloC 1-7 alkyl, carbamoyl, C 1-7 -alkylaminocarbonyl or di-C 1-7 alkylaminocarbonyl; R 10 , R 11 and R 12 for each occurrence are independently H, C 3-8 cycloalkyl, halo-C 1-7 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-7 alkyl, heteroaryl, heteroaryl-C 1-7 alkyl, heterocyclyl, heterocyclyl-C 1-7 alkyl; or R 11 and R 13 taken together with the nitrogen to which they are attached form a 3 to 8-membered heterocyclyl ring or a 5-membered heteroaryl ring; n is 0 or 1; p is 0, 1, 2, 3, 4 and 5; or a pharmaceutically acceptable salt thereof.