Patent ID: 8071586

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: A is phenyl or naphthyl, wherein said phenyl and naphthyl are optionally substituted by one to three substituents selected from the group consisting of halogen, halo C 1-6 alkyl, and aryl; X is â€”N(R 1 )(R 2 ), wherein R 1 and R 2 , together with the nitrogen atom to which they are attached, form a piperindyl or 6-aza-spiro[2.5]oct-6-yl, optionally substituted by one to three substituents independently selected from the group consisting of hydroxy, C 1-6 alkyl and hydroxy C 1-6 alkyl; Y 1 is C(O) or S(O) 2 ; Y 2 is O or S; and Y 3 is NH or O; R 3 and R 4 are independently selected from the group consisting of: (1) hydrogen, (2) hydroxy, (3) C 1-6 alkyl, (4) C 1-6 alkoxy, (5) C 3-7 cycloalkyl, (6) C 3-7 cycloalkyl C 1-6 alkyl, (7) C 1-6 alkoxycarbonyl, (8) carboxyl, (9) carbamoyl, (10) mono- or di-C 1-6 alkyl substituted carbamoyl, (11) C 1-6 alkoxycarbonyloxy, (12) mono- or di-C 1-6 alkyl substituted aminocarbonyloxy, (13) C 1-20 alkylcarbonyloxy-C 1-6 alkyl, (14) C 1-20 alkoxycarbonyloxy-C 1-6 alkyl, (15) arylcarbonyloxy-C 1-6 alkyl, (16) mono- or di-C 1-6 alkyl substituted aminocarbonyloxy-C 1-6 alkyl, (17) hydroxy-C 1-6 alkyl, (18) C 1-6 alkoxy-C 1-6 alkyl, (19) halogen or halo C 1-6 alkyl, and (20) aryl substituted aminocarbonyloxy-C 1-6 alkyl, wherein said aryl substituent is optionally substituted by one to three substituents independently selected from the group consisting of halogen, C 1-6 alkyl, halo C 1-6 alkyl, C 1-6 alkoxy and halo C 1-6 alkoxy; or alternatively, R 3 and R 4 , together with the carbon atom to which they are attached, form a C 3-7 cycloalkyl or heterocyclyl which is optionally substituted by one to three substituents independently selected from the group consisting of C 1-4 alkyl, halo C 1-4 alkyl and halogen; R 5 and R 6 are independently hydrogen or C 1-6 alkyl; R 7 , R 8 , R 9 and R 10 are independently hydrogen or C 1-6 alkyl; n is an integer of 0 to 3; m is an integer of 0 to 3; and m+n is an integer of 1 to 5; and p is 0 or 1.