Patent ID: 7888384

Claim:
A compound having formula I-A, or formula I-B: or a pharmaceutically acceptable salt thereof, wherein: R 5 and R 7 are independently defined by —ZR 6 , wherein Z is a bond or is an optionally substituted C 1 -C 6 alkyl, alkenyl, or alkynyl, chain wherein up to two carbon units of Z are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR′—, —CONR′NR′—, —CO 2 —, —OCO—, —NR′CO 2 —, —O—, —NR′CONR′—, —OCONR′—, —NR′NR′, —NR′NR′CO—, —NR′CO—, —S—, —SO, —SO 2 —, —NR′—, —SO 2 NR′—, NR′SO 2 —, or —NR′SO 2 NR′—; wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, polycyclic hydrocarbon, substituted polycyclic hydrocarbon; or R 1 and R 2 together form an unsubstituted or substituted 3 to 7-membered ring, wherein the members of the ring contain 0-4 heteroatoms selected from nitrogen, oxygen, and sulfur; R 3 and R 4 together form an unsubstituted or substituted 3 to 7-membered ring, wherein the members of the ring are selected from the group consisting of carbon, nitrogen, oxygen, and sulfur; the group SO 2 NR 3 R 4 is linked to the phenyl ring either at position 5 or 6; X is N—Z—R 6 ; n is 0-3; R 6 is independently R′, halogen, NO 2 , CN, CF 3 , or OCF 3 ; R′ is independently selected from hydrogen or an optionally substituted group selected from a C 1 -C 8 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or two occurrences of R′ are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; provided that in compounds of formula I-A: when R 3 and R 4 , together with the intervening nitrogen atom, form a 4-benzyl-piperidin-1-yl ring, R 5 is hydrogen, then R 1 and R 2 are not simultaneously hydrogen.