Patent ID: 6972286

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is a) —NHC(═W)R 1 ; b) —O-het, —S-het, or —NH-het; X is —NR 3 —, W is a) O, or b) S; R 1 is a) H, b) C 1-8 alkyl, c) C 3-6 cycloalkyl, d) OC 1-4 alkyl e) SC 1-4 alkyl, f) NH 2 , g) NHC 1-6 alkyl, or h) N(C 1-6 alkyl) 2 ; R 2 is a) H, b) halo, or c) C 1-4 alkyl; R 3 is a) H, b) C 1-8 alkyl, c) aryl, d) C(═W)R 5 , e) C(═O)OR 6 , or f) S(═O) i R 7 ; R 4 is a) H, or b) C 1-8 alkyl; R 5 is a) H, b) aryl, c) NR 8 R 9 , or d) C 1-8 alkyl; R 6 is a) C 1-8 alkyl, b) aryl, or R 7 is a) aryl, b) NR 8 R 9 , or c) C 1-8 alkyl; R 8 and R 9 are independently a) H, b) C 1-8 alkyl, or c) aryl; wherein >G-E- is >N—C— and Q is a carbon atom; aryl is a phenyl radical or an ortho-fused bicyclic carbocyclic radical wherein at least one ring is aromatic; het is a C-linked five- (5) or six- (6) membered saturated or unsaturated heterocyclic ring having 1, 2, or 3 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen, which is optionally fused to a benzene ring; at each occurrence, alkyl or cycloalkyl is optionally substituted with one or more OR 8 , halo, aryl, S(═O) i R 7 , C(═W)R 8 , OC(═O)C 1-6 alkyl, or NR 8 R 9 ; at each occurrence, aryl is optionally substituted with one or more halo, OH, CF 3 , OC 1-6 alkyl, CN, C 1-6 alkyl, S(═O) i R 7 , C(═W)R 8 , OC(═O)R 8 , NHC(═O)R 8 , or NR 8 R 9 ; at each occurrence, het is optionally substituted with one or more halo, OH, CF 3 , OC 1-6 alkyl, CN, C 1-6 alkyl, S(═O) i R 7 , C(═W)R 8 , OC(═O)R 8 , NHC(═O)R 8 , or NR 8 R 9 , oxo, or oxime; m is 2; n is 2; and i is 0, 1, or 2.