Patent ID: 6916460

Claim:
A compound of formula (II): and pharmaceutically acceptable salts thereof wherein: R 1 , R 2 , R 3 and R 4 are independently selected at each occurrence from the group: C 1 -C 10 alkyl substituted with 0-5 R 5 , C 2 -C 10 alkenyl substituted with 0-5 R 5 and aryl substituted with 0-5 R 5 ; R 5 is independently elected at each occurrence from the group: H, C(═O)OR 18 , C 1 -C 10 alkyl substituted with 0-5 R 13 , C 2 -C 10 alkenyl substituted with 0-5 R 13 , aryl substituted with 0-5 R 13 and heterocycle substituted with 0-5 R 13 ; X is P(═O)R 9 ; A is CH 2 ; Q 1 , Q 2 , and Q 3 are independently —(CR 11 R 12 ) n − , wherein: n is 2-5; R 9 is selected from the group: OR 14 , NR 15 R 16 and CH 2 NR 15 R 16 ; R 11 and R 12 are independently selected from the group: H, C 1 -C 10 alkyl substituted with 0-5 R 17 , C 2 -C 10 alkenyl substituted with 0-5 R 17 and aryl substituted with 0-3 R 17 ; R 13 is independently selected at each occurrence from the group: H, OH, NHR 18 , C(═O)R 18 , OC(═O)R 18 , OC(═O)OR 18 , C(═O)OR 18 , C(═O)NR 2 18 , PO 3 R 2 18 , SR 18 , SOR 18 , SO 2 R 18 , NHC(═O)R 18 , NHC(═O)NHR 18 , CH 2 OR 18 , CH 3 and NHC(═S)NHR 18 ; R 14 , R 15 and R 16 are independently selected from the group: hydrogen, C 1 -C 10 alkyl substituted with 0-5 R 13 , C 2 -C 10 alkenyl substituted with 0-5 R 13 and aryl substituted with 0-5 R 13 ; or, alternatively, two R 14 or R 15 and R 16 may be taken together to form a transannular bridge, said bridge selected from the group: C 3 -C 10 alkyl substituted with 0-5 R 13 and ortho-aryl substituted with 0-3 R 13 ; R 17 is independently selected at each occurrence from the group: H, OH, NHR 18 , C(═O)R 18 , OC(═O)R 18 , OC(═O)OR 18 , C(═O)OR 18 , C(═O)NR 2 18 , PO 3 R 2 18 , SR 18 , SOR 18 , SO 2 R 18 , NHC(═O)R 18 , NHC(═O)NHR 18 and NHC(═S)NHR 18 ; and R 18 is independently selected at each occurrence from the group: H, C 1 -C 6 alkyl, benzyl and phenyl.