Patent ID: 8288540

Claim:
A compound having the structure of Formula (2A), Formula (2B) or Formula (2C), or a pharmaceutically acceptable salt thereof: wherein: R 1 and R 2 are independently C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, each of which is optionally substituted with halo, amino or hydroxyl groups; halo, cyano, nitro, (CR 2 ) k OR 7 , (CR 2 ) k O(CR 2 ) 1-4 R 7 , (CR 2 ) k SR 7 , (CR 2 ) k NR 9 R 10 , (CR 2 ) k (O)O 0-1 R 7 , OC(O)R 7 , (CR 2 ) k C(S)R 7 , (CR 2 ) k C(O)NR 9 R 10 , (CR 2 ) k C(O)NR(CR 2 ) 0-6 C(O)O 0-1 R 7 , (CR 2 ) k NRC(O)O 0-1 R 7 , (CR 2 ) k S(O) 1-2 NR 9 R 10 , (CR 2 ) k S(O) 1-2 R 8 , (CR 2 ) k NRS(O) 1-2 R 8 or (CR 2 ) k R 6 ; or any two adjacent R 2 groups together with the atoms they are attached to form an optionally substituted 5-8 membered carbocyclic, heterocyclic, aryl or heteroaryl ring; R 3 is -L-NR 4 R 5 , â€”Xâ€”NRâ€”C(O)R 8 or â€”Xâ€”NRâ€”C(O)NR 4 R 5 wherein L is â€”Xâ€”C(O), â€”Xâ€”OC(O), â€”SO 0-2 (CR 2 ) j , (CR 2 ) 1-4 , â€”O(CR 2 ) 1-4 , or and X is (CR 2 ) j or [C(R)(CR 2 OR)]; R 4 , R 5 , R 9 and R 10 are independently H; C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, each of which is optionally substituted with halo, amino, hydroxyl, alkoxy, cyano, carboxyl or R 6 ; (CR 2 ) k CN, (CR 2 ) 1-6 NR 7 R 7 , (CR 2 ) 1-6 OR 7 , (CR 2 ) k C(O)O 0-1 R 7 , (CR 2 ) k C(O)NR 7 R 7 or (CR 2 ) k â€”R 6 ; R 6 is an optionally substituted C 3-7 cycloalkyl, C 6-10 aryl, or a 5-10 membered heteroaryl or 5-7 membered heterocyclic ring; R 7 and R 8 are independently (CR 2 ) k â€”R 6 or C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, each of which is optionally substituted with halo, amino, amido, hydroxyl, alkoxy, cyano, carboxyl or R 6 ; or R 7 is H; alternatively, R 4 and R 5 together with N in each NR 4 R 5 , R 7 and R 7 together with N in NR 7 R 7 or R 9 and R 10 together with N in NR 9 R 10 form a 4-7 membered heterocyclic ring optionally substituted with 1-3 R 11 groups and optionally containing NR 12 , O, S, â•O or a double bond; R 11 is R 8 , (CR 2 ) k â€”OR 7 , CO 2 R 7 , (CR 2 ) k â€”C(O)â€”(CR 2 ) k â€”R 8 , (CR 2 ) k C(O)NR 7 R 7 , (CR 2 ) k C(O)NR(CR 2 ) 0-6 C(O)O 0-1 R 7 , (CR 2 ) k NRC(O)O 0-1 R 7 , (CR 2 ) k S(O) 1-2 NR 7 R 7 , (CR 2 ) k S(O) 1-2 R 8 or (CR 2 ) k NRS(O) 1-2 R 8 ; R 12 is H, R 8 , â€”(CR 2 ) 1-4 CO 2 R 7 , (CR 2 ) k â€”C(O)â€”(CR 2 )â€”R 8 , (CR 2 ) k C(O)NR 7 R 7 , (CR 2 ) k C(O)NR(CR 2 ) 0-6 C(O)O 0-1 R 7 , (CR 2 ) 1-4 NRC(O)O 0-1 R 7 , (CR 2 ) k S(O) 1-2 NR 7 R 7 , (CR 2 ) k S(O) 1-2 R 8 or (CR 2 ) k NRS(O) 1-2 R 8 ; each R is H or C 1-6 alkyl; each k is 0-6; j is 0-4; m is 0, 1, 2 or 3; provided R 8 in â€”Xâ€”NRâ€”C(O)R 8 is not phenyl when X is (CR 2 ) 0 .