Patent ID: 6953787

Claim:
A compound of Formula (I): wherein: R 1 is H or C 1-8 alkyl; R 2 is C 1-8 alkyl, —CH 2 —O—C 1-8 alkyl, —C(═O)—O—C 1-8 alkyl, —C(═O)—NH—C 1-8 alkyl, OH, or CH 2 OH; R 2a is H; or R 2 and R 2a together form —CH 2 —CH 2 —; R 3 is halogen, perhaloalkyl, CN, SR 5 , NHR 5 , N(R 5 ) 2 , aryl, or heteroaryl, wherein said aryl can be optionally substituted with up to two substituents selected from C 1-8 alkyl, halogen, perhalo alkyl, and alkoxy, and said heteroaryl can be optionally substituted with up to two substituents selected from halogen and C 1-8 alkyl; R 4 is H, halogen, perhaloalkyl, CN, SR 5 , NHR 5 , N(R 5 ) 2 , aryl, or heteroaryl, wherein said aryl can be optionally substituted with up to two substituents selected from C 1-8 alkyl, halogen, perhalo alkyl, and alkoxy, and said heteroaryl can be optionally substituted with up to two substituents selected from halogen and C 1-8 alkyl; each R 5 is independently C 1-8 alkyl, C 1-8 alkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl or perhaloalkyl, or allyl; and R 6 is H or C 1-8 alkyl; wherein heteroaryl is pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidinyl, furanyl, pyranyl, thienyl, benzimidazolyl, quinolinyl, isoquinolinyl, oxazolyl, thiazolyl or thiadiazolyl; or a pharmaceutically acceptable salt, solvate or hydrate thereof provided that: (B) if R 6 is other than H, then neither R 3 nor R 4 can be H; (C) if R 1 and R 2 are methyl, and R 4 is H, then R 3 cannot be NHR 5 or N(R 5 ) 2 ; and (D) if R 1 and R 2 are methyl, and R 4 is H, then R 3 cannot be imidazole, substituted imidazole, or an imidazole derivative.