Patent ID: 7074615

Claim:
A cell adhesion promoting (CAP) peptide-modified polymer composition useful for promoting cell attachment or growth, comprising a polymer surface comprising a cell adhesion resistant (CAR) material to which one or more peptides are covalently bound, forming a peptide-modified CAP surface, which peptides/surface promote attachment of cells, which cells substantially do not attach to said CAR surface in the absence of said peptides, wherein each of said one or more peptides comprises: (a) one or more peptide sequences selected from the group consisting of SEQ ID NO: 2 (EFIKY), SEQ ID NO: 3 (EEEKV), SEQ ID NO: 4 (GHK), SEQ ID NO: 6 (KKLVY), SEQ ID NO: 8 (AFAFK), SEQ ID NO: 10 (KMLIY), SEQ ID NO: 11 (KSYYY), SEQ ID NO: 12 (AKKMV), SEQ ID NO: 14 (AFIPV), SEQ ID NO: 15 (KKMYY), and SEQ ID NO: 16 (AIKKK); (b) a chemically or recombinantly prepared peptide multimer that includes at least two repeats of any one or a combination of SEQ ID NOs: 2â€“4, 6, 8, 10â€“12, and 14â€“16; or (c) a cell adhesion promoting variant of any one or more of SEQ ID NOs: 2â€“4, 6, 8, 10â€“12, and 14â€“16, said variant having a conservative substitution of a single amino acid residue, wherein said variant has the ability to promote cell attachment or growth; wherein said CAR material is hyaluronic acid (HA).