Patent ID: 7803827

Claim:
A compound having Formula I: wherein R is optionally substituted phenyl; R 1 is optionally substituted phenyl, optionally substituted C 3 -C 7 cycloalkyl, or optionally substituted heteroaryl; R 2 is hydrogen or is selected from: i) —SO 2 [C(R 5a R 5b )] j R 4 ; ii) —C(O)[C(R 5a R 5b )] k R 4 ; or iii) —[C(R 5a R 5b )] n R 4 ; R 3 is hydrogen or is selected from: i) C 1 -C 4 linear or branched alkyl, or C 3 -C 7 cycloalkyl; ii) —SO 2 [C(R 5a R 5b )] j R 4 ; or iii) —[C(R 5a R 5b )] n R 4 ; or R 2 and R 3 are taken together with the atom to which they are bound to form an optionally substituted ring having from 3 to 7 ring atoms optionally containing one or more additional heteroatom ring atoms selected from N, O, or S; R 5a and R 5b are each independently hydrogen or C 1 -C 4 linear alkyl; R 4 is selected from; i) hydrogen; ii) —N(R 6a R 6b ); iii) —SO 2 R 7 ; iv) —C(O)N(R 8a R 8b ); v) optionally substituted C 1 -C 6 linear or branched alkyl, or optionally substituted C 3 -C 6 cycloalkyl; vi) optionally substituted C 2 -C 6 linear or branched alkenyl; vii) optionally substituted C 1 -C 6 linear or branched alkoxy; viii) optionally substituted C 6 or C 10 aryl; ix) optionally substituted C 6 or C 10 aryloxy; x) optionally substituted heteroaryl; xi) optionally substituted heterocycle; or xii) optionally substituted C(O)O(arylalkyl); R 6a and R 6b are each independently hydrogen, optionally substituted C 1 -C 6 linear or branched alkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted benzyl, optionally substituted phenyl, or —C(O)OR 7a , or R 6a and R 6b are taken together with the atom to which they are bound to form a ring having from 3 to 7 ring atoms optionally containing one or more additional heteroatom ring atoms selected from N, O, or S; R 7 is hydrogen, optionally substituted C 1 -C 6 linear or branched alkyl, optionally substituted C 3 -C 6 cycloalkyl, or N(R 7a ) 2 ; R 7a , at each occurrence, independently, is hydrogen, optionally substituted C 1 -C 6 linear or branched alkyl, or optionally substituted C 3 -C 6 cycloalkyl; R 8a and R 8b are each independently hydrogen, optionally substituted C 1 -C 6 linear or branched alkyl, optionally substituted C 3 -C 6 cycloalkyl, or R 8a and R 8b are taken together with the atom to which they are bound to form a ring having from 3 to 7 ring atoms optionally containing one or more additional heteroatom ring atoms selected from N, O, or S; L and L 1 are, independently, —[C(R 9a R 9b )] m —; R 9a and R 9b are, at each occurrence, each independently hydrogen or methyl, or R 9a and R 9b are taken together with the atom to which they are bound to form a cyclopropyl ring; x and y are independently 0 or 1; m, at each occurrence, independently is 0 to 4; j, at each occurrence, independently is 0 to 4; and k and n, at each occurrence, are independently 0 to 3; or a pharmaceutically acceptable salt form thereof.