Patent ID: 7220753

Claim:
A pharmaceutical composition comprising an effective amount of a compound of the formula I or pharmaceutically acceptable salts thereof in combination with a serotonin reuptake inhibitor, wherein Ar is phenyl, naphthyl, benzoxazolonyl, indolyl, indolonyl, benzimidazolyl, quinolyl, fuzyl, benzofuryl, thienyl, benzothienyl, oxazolyl, or benzoxazolyl; Aris phenyl, pyridinyl, pyridazinyl, pyrimidinyl, or pyrazirmyl; A is O, S, SO 2 , C=O, CHOH or (CR 3 R 4 )—; n is 0, 1 or 2; each of Ar and Ar 1 may be independently and optionally substituted with one to four substiLuents independently selected from the gwup consisting of fluoro, chioro, bromo, iodo, cyano, nitro, thiocyano, —SR, —SOR. —SO 2 R, —NHSO 2 R, —(C 1 –C 6 )alkoxy, —NR 1 R 2 , —NHCOR 1 , —CONR 1 R 2 , Ph, —COR, COOR, —(C 1 –C 6 )alkyl, —(C 1 –C 6 )alkyl substituted with one to six halogens, —(C 3 –C 6 )cycloalkyl and trifluoromethoxy; each and every R, R 1 , and R 2 is independently selected from the group consisting of hydrogen, —(C 1 –C 6 )alkyl, —(C 1 –C 6 )alkyl substituted with one to thirteen halogens selected from the group consisting of fluorine, chlorine, bromine, and iodine, phenyl, benzyl, —(C 2 –C 6 )alkenyl, —(C 3 –C 6 )cycloalkyl and (C 1 –C 6 )alkoxy; and each and every R 3 and R 4 is independently selected from a group consisting of hydrogen, methyl, ethyl, n-propyl and i-propyl, wherein the serotonin reuptake inhibitor is sertraline, fluoxetine, fenfluran,ine, or fluvoxainine.