Patent ID: 8685666

Claim:
A method for detecting breast cancer or prostate cancer or a precancerous lesion of the breast or prostate, comprising: contacting, in vitro, a breast tissue sample or a prostate tissue sample from a human with one or more isolated antibodies or antigen-binding fragments thereof that specifically bind to human reductase-like-1 (ARL-1) protein, wherein the one or more isolated antibodies or antigen-binding fragments thereof comprise an isolated antibody produced by immunizing an animal using a peptide antigen with the amino acid sequence identified by SEQ ID NO:1, wherein the antibody is a monoclonal antibody; detecting expression of the ARL-1 protein in the sample based on said contacting step; comparing expression of the ARL-1 protein, detected in said detecting step, with expression of the ARL-1 protein in a normal breast tissue sample or a normal prostate tissue sample; and detecting breast cancer or prostate cancer or precancerous lesion of the breast or the prostate when expression of detected ARL-1 protein is greater than expression of detected ARL-1 protein in said normal breast tissue sample or said normal prostate tissue sample.