Patent ID: 8742078

Claim:
A compound of formula I: wherein: each R 1 and R 2 is, independently, H or an amino protecting group; each R 3 is, independently, H or a hydroxyl protecting group; R 4 and R 5 are each, independently, H, amino protecting group, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl or substituted C 2 -C 12 alkynyl; Q 1 is hydroxyl, a protected hydroxyl, cyano, azido, or NR 8 R 9 ; R 8 and R 9 are each, independently, H, CN, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 7 -C 9 alicyclic radical, substituted C 7 -C 9 alicyclic radical, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl or substituted C 2 -C 12 alkynyl; Q 2 is NH 2 or N(CH 2 R 6 )R 7 ; R 6 and R 7 are each, independently, H, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 7 -C 9 alicyclic radical, substituted C 7 -C 9 alicyclic radical, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl or substituted C 2 -C 12 alkynyl; wherein said substituents are each, independently, halogen, trifluoromethyl, cyano, OJ 3 , NJ 1 J 2 , C(═O)—NJ 1 J 2 , N(H)C(═O)-J 1 , N(J 1 )—(CH 2 ) n —OJ 3 , N(J 1 )—(CH 2 ) n —NJ 1 J 2 , C 5 -C 20 aryl, C 7 -C 9 alicyclic radical, heterocycle radical, heteroaryl, azido, carboxy, acyl (C(═O)—X), ═O, cyano, sulfonyl (S(═O) 2 —X) or sulfoxyl (S(═O)—X); each X is, independently, H or C 1 -C 12 alkyl; each J 1 and J 2 is, independently, H, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 5 -C 20 aryl, acyl (C(═O)—X), a heterocycle radical or heteroaryl; each J 3 is, independently, H, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 12 aminoalkyl or a hydroxyl protecting group; each n is, independently, from 1 to 20; and with the proviso that when Q 1 is hydroxyl or protected hydroxyl, Q 2 is other than NH 2 , NH(CH 3 ) or NH(CH 2 CH 3 ).