Patent ID: 8796416

Claim:
A method of prophylactically treating acute kidney injury (AKI) in an individual in need thereof comprising selecting an individual suspected of having, predisposed to, or at risk of developing acute kidney injury and administering an adrenocorticotropic hormone (ACTH) peptide to the individual in need thereof, wherein the ACTH peptide is administered as a first dose and one or more subsequent doses; and wherein the ACTH peptide is selected from the group consisting of: (a) the ACTH 1-39 peptide consisting of the sequence: (SEQ ID NO: 1) H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly- 1 2 3 4 5 6 7 8 9 10 Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val- 11 12 13 14 15 16 17 18 19 20 Lys-Val-Tyr-Pro-Asp-Gly-Ala-Glu-Asp-Gln- 21 22 23 24 25 26 27 28 29 30 Leu-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH; 31 32 33 34 35 36 37 38 39 (b) the ACTH 1-24 peptide consisting of the sequence: (SEQ ID NO: 2) H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly- 1 2 3 4 5 6 7 8 9 10 Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val- 11 12 13 14 15 16 17 18 19 20 Lys-Val-Tyr-Pro; and 21 22 23 24 (c) the ACTH peptide is ACTH 1-17 peptide consisting of the sequence of: (SEQ ID NO: 3) H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly- 1 2 3 4 5 6 7 8 9 10 Lys-Pro-Val-Gly-Lys-Lys-Arg. 11 12 13 14 15 16 17