Patent ID: 8907091

Claim:
A process for preparing a compound of Formula (A): and pharmaceutically acceptable salts thereof, wherein D is pyridine optionally substituted with 1 to 5 independently selected R 38 ; M is Z is —O—; Ar is phenyl; and G is wherein each R 38 is independently selected from —(CH 2 ) j NR 39 (CH 2 ) n R 36 and —(CH 2 ) n NR 36 R 39 , wherein each j is an integer independently ranging from 0 to 4 and n is an integer ranging from 0 to 6; R 36 is selected from the group consisting of H, —OH, C 1 -C 6 alkyl, —(CH 2 ) n O(CH 2 ) i OR 37 , —(CH 2 ) n CN(CH 2 ) n OR 37 , —(CH 2 ) n CN(CH 2 ) n R 37 , and —(CH 2 ) n OR 37 , wherein each n is an integer independently ranging from 0 to 6 and i is an integer ranging from 2 to 6; R 37 is selected from H, —O—C 1 -C 6 alkyl, and optionally substituted C 1 -C 6 alkyl; R 39 is selected from the group consisting of H and C 1 -C 6 alkyl; R 13 is —H, Q is phenyl optionally substituted with between zero and four halogens; R 11 and R 12 are H the process comprising reacting a compound represented by the Formula (A-1) wherein PG is a R 38 substituent protected with a protecting group; and RG 1 is —NH 2 ; with a compound represented by the Formula (A-2): RG 2 -G 1 (A-2), wherein RG 2 G 1 is wherein the reaction is performed at 70° C. in a mixture of isopropanol and acetonitrile, such that the reaction of —RG 1 with RG 2 -G 1 forms and removing the protecting group.