Patent ID: 8853230

Claim:
A method for inhibiting JAK or a signal transduction pathway mediated at least in part by JAK activity comprising the step of contacting a cell with a compound having the formula I: or a tautomer or pharmaceutically acceptable salt thereof, wherein: Y 1 is N or CR 1c ; R 1a is benzyl, optionally substituted with from 1 to 3 substituents selected from the group consisting of C 2-8 alkenyl, C 2-8 alkynyl, amino, hydroxy, halogen, C 1-8 heteroalkyl, cyano, C 3-8 cycloalkyl, aryl, haloaryl, C 1-8 alkylaryl, and C 1-8 alkoxyaryl, heteroaryl, C 3-8 heterocyclyl and C 3-8 heterocyclylcarbonyl ; R 1b is H or C 1-8 alkyl; R 1c is H, C 1-8 alkyl or halogen; R 2 is H, C 1-8 alkyl, C 1-8 heteroalkyl, heterocyclylC 1-8 alkoxy, halogen or heterocyclyl; R 3 is H or C 1-8 alkyl or C 3-8 cycloalkyl; R 4 is selected from the group consisting amino, C 1-8 alkyl, aminoC 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 heteroalkyl, C 3-8 cycloalkyl, aryl, heteroaryl and C 3-8 heterocyclyl; and m is 0,1,2 or 3.