Patent ID: 6963000

Claim:
A compound of formula IA wherein R 1 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, cycloalkyloxy, halogen, hydroxy or trifluoromethyloxy; R 2 , R 3 are independently from each other hydrogen, halogen, lower alkyl or lower alkyloxy; R 4 is phenyl, which is optionally attached to the benzo group via the linker —(O) m —(CH 2 ) n — and is unsubstituted or substituted by N(R 5 )(R 6 ), halogen or nitro, R′ is phenyl, unsubstituted or substituted by halogen-lower alkyl, —C(O)H or by the following groups —(CH 2 ) n —C(O)—N(R 5 )—(CH 2 ) n lower alkoxy, —(CH 2 ) n O-halogen-lower alkyl, —(CH 2 ) n O—(CH 2 ) n+1 O-lower alkyl, —S(O) 2 —N(R 5 )—(CH 2 ) n O-lower alkyl, —(CH 2 ) n OR 5 , —(CH 2 ) n N(R 5 )—(CH 2 ) o -lower alkoxy, —(CH 2 ) n N[(CH 2 ) o -lower alkoxy] 2 , —(CH 2 ) n N[S(O) 2 CH 3 ] 2 , —(CH 2 ) n N[R 5 ][S(O) 2 CH 3 ], —(CH 2 ) n N(R 5 )-lower alkenyl, —(CH 2 ) n N(R 5 )—(CH 2 ) o -cycloalkyl, —(CH 2 ) n N(R 5 )—C(O)O-lower alkyl, —(CH 2 ) n —S—(CH 2 ) n —N(R 5 )(R 6 ), —(CH 2 ) n N(R 5 )—(CH 2 ) o —S-lower alkyl, —(CH 2 ) n N(R 5 )—S(O) 2 CH 3 —(CH 2 ) n N(R 5 )—(CH 2 ) o -phenyl, —(CH 2 ) n N(R 5 )—(CH 2 ) o CH(OH)—CF 3 , —(CH 2 ) n N(R 5 )—(CH 2 ) o —CF 3 , —(CH 2 ) n N(R 5 )—(CH 2 ) o —O—CH(OH)—C 6 H 3 (OCH 3 ) 2 , —(CH 2 ) n N(R 5 )—(CH 2 ) o —O—C(O)—C 6 H 3 (OCH 3 ) 2 , —N(R 5 )—C(O)-morpholin, —N(R 5 )—C(O)—N(R 5 )-phenyl, substituted by alkoxy, —S(O) 2 -morpholin, or is phenyl, which is unsubstituted or substituted by —(CR 5 R 6 ) n — five to seven membered aromatic or non aromatic heterocycle, and wherein the heterocycle is unsubstituted or substituted by hydroxy, —N(R 5 )(R 6 ) or lower alkyl, or by —(CH 2 ) n N(R 5 )(CH 2 ) o — five or six membered aromatic or non aromatic heterocycle and wherein the heterocycle is unsubstituted or substituted by hydroxy, —N(R 5 )(R 6 ) or lower alkyl, or is —N(R 5 )-phenyl, which is unsubstituted or substituted by lower alkoxy, or X is O,S, or two hydrogen atoms; R 5 , R 6 are independently from each other hydrogen or lower alkyl; n is 0, 1, 2, 3 or 4; m is 0 or 1; o is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.