Patent ID: 7851588

Claim:
A 38-residue or 39-residue CRFR1 ligand cyclic peptide which binds to CRFR1 with an affinity substantially greater than it binds to CRFR2, which peptide has the following formula, or a nontoxic salt thereof: wherein the side chains of Glu and Lys are covalently linked as indicated; Y 1 is an acyl group having not more than 7 carbon atoms or is radioiodinated tyrosine; R 14 is CML or Leu; R 18 is Val or CML; R 32 is His or D-His; R 33 is Aib, Ser, D-Ser or D-Ala; R 36 is Lys or CML; R 37 is CML or Leu; and R 40 is Ile or CML; provided that D-β-(2-napthyl)alanine(D-2Nal) or D-Leu may be substituted for D-Phe.