Patent ID: 7186838

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt or an enantiomer thereof; wherein n is 0, 1 or 2; a-b represents CF═CH, CHFCH 2 , or CF 2 CH 2 ; R 1 is hydrogen, hydroxymethyl, or C 1-3 alkyl, wherein alkyl is unsubstituted or substituted with one to seven fluorine atoms; R 2 is hydrogen or C 1-4 alkyl; R 3 is selected from (CH 2 ) n -cycloheteroalkyl, and (CH 2 ) n -aryl, wherein aryl is selected from (1) phenyl, (2) naphthyl, (3) benzimidazolyl, or imidazopyridin (4) benzofuranyl, (5) benzothiophenyl, (6) benzoxazolyl, (7) benzothiazolyl, (8) benzodihydrofuranyl, (9) 1,3-benzodioxolyl, (10) 2,3-dihydro-1,4-benzodioxinyl, (11) indolyl, (12) quinolyl, (13) isoquinolyl, (14) furanyl, (15) thienyl, (16) imidazolyl, (17) oxazolyl, (18) thiazolyl, (19) isoxazolyl, (20) isothiazolyl, (21) pyrazolyl, (22) pyrrolyl, (23) pyridyl, (24) pyrimidyl, (25) pyrazinyl, (26) thiadiazolyl, (27) oxadiazolyl, (28) triazolyl, (29) tetrazolyl, and (30) indanyl; wherein the alkyl group or the cycloheteroalkyl group is unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, and C 1-4 alkoxy; the aryl group as defined in items (1) to (30) is unsubstituted or substituted with one to three groups independently selected from halogen, phenyl, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloheteroalkyl, phenyl-C 1-6 alkyl, amino-C 0-6 alkyl, C 1-6 alkylamino-C 0-6 alkyl, (C 1-6 alkyl) 2 amino-C 0-6 alkyl, phenyl-C 0-6 alkylamino-C 0-6 alkyl, (phenyl-C 0-6 alkyl)2amino-C 0-6 alkyl, C 1-6 alkylthio, phenyl-C 0-6 alkylthio, C 1-6 alkylsulfinyl, phenyl-C 0-6 alkylsulfinyl, C 1-6 alkylsulfonyl, phenyl-C 0-6 alkylsulfonyl, C 1-6 alkoxy-C 0-6 alkyl, phenyl-C 0-6 alkoxy-C 0-6 alkyl, hydroxycarbonyl-C 0-6 alkyl, C 1-6 alkoxycarbonyl-C 0-6 alkyl, phenyl-C 0-6 alkoxycarbonyl-C 0-6 alkyl, hydroxycarbonyl-C 1-6 alkyloxy, hydroxy-C 0-6 alkyl, cyano, nitro, perfluoro-C 1-4 alkyl, perfluoro-C 1-4 alkoxy, oxo, C 1-6 alkylcarbonyloxy, phenyl-C 0-6 alkylcarbonyloxy, C 1-6 alkylcarbonylamino, phenyl-C 0-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, phenyl-C 0-6 alkylsulfonylamino, C 1-6 alkoxycarbonylamino, phenyl-C 0-6 alkoxycarbonylamino, C 1-6 alkylaminocarbonylamino, phenyl-C 0-6 alkylaminocarbonylamino, (C 1-6 alkyl) 2 aminocarbonylamino, (phenyl-C 0-6 alkyl) 2 aminocarbonylamino, (C 1-6 alkyl) 2 aminocarbonyloxy, and (phenyl-C 0-6 alkyl) 2 aminocarbonyloxy; and wherein any methylene (CH 2 ) carbon atom in (CH 2 ) n is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; or two substituents when on the same methylene (CH 2 ) group are taken together with the carbon atom to which they are attached to form a cyclopropyl group; or R 2 and R 3 together form a 5- or 6-membered saturated ring fused with a 5- or 6-membered aromatic ring system having 0, 1, or 2 heteroatoms selected from the N, O, and S.