Patent ID: 7592356

Claim:
A compound of formula a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently of the other; Y is C 1-4 alkanediyl, C 2-4 alkenediyl, C 2-4 alkynediyl, C(═O), or a direct bond; R 1 is hydrogen, cyano, aryl or a substituted or unsubstituted C 1-14 heterocycle; ═Z 1 —Z 2 ═Z 3 — represents a radical of formula ═N—N═CH— (a-1) ═N—CH═N— (a-2) ═CH—N═N— (a-3) X is SO 2 , (CH 2 ) n wherein n is 1 to 4, C(═O), C(═S), or a direct bond R 2 is aryl, C 3-7 cycloalkyl, C 3-7 cycloalkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted C 1-14 heterocycle, C 3-7 cycloalkyl, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, hydroxyC 1-6 alkyl, hydroxyC 1-6 alkyloxy, hydroxyC 1-6 alkylthio and arylC 1-6 alkylthio, C 1-12 alkyl or C 1-12 alkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted C 1-14 heterocycle, C 3-7 cycloalkyl, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, hydroxyC 1-6 alkyl, hydroxyC 1-6 alkyloxy, hydroxyC 1-6 alkylthio and arylC 1-6 alkylthio; R 3 is aryl, —NR 5 R 6 , a substituted or unsubstituted C 1-14 heterocycle, or C 2-4 alkenediyl substituted with a substituted or unsubstituted C 1-14 heterocycle or aryl; R 4 is hydrogen, aryl, C 3-7 cycloalkyl, C 1-6 alkyl or C 1-6 alkyl substituted with C 3-7 cycloalkyl, hydroxycarbonyl, C 1-4 alkyloxycarbonyl or aryl; R 5 and R 6 are each independently selected from hydrogen, a substituted or unsubstituted C 1-14 heterocycle, aryl, C 1-12 alkyl and C 1-12 alkyl substituted with one or more substituents selected from hydroxy, aryl, aryloxy or a substituted or unsubstituted C 1-14 heterocycle; R 7 is substituted or unsubstituted phenyl, —NR 8 R 9 or a substituted or unsubstituted C 1-14 heterocycle; R 8 and R 9 are independently selected from hydrogen, substituted or unsubstituted phenyl, C 3-6 cycloalkyl, a substituted or unsubstituted C 1-14 heterocycle, C 1-6 alkyl and C 1-6 alkyl substituted with one or more substituents independently selected from C 1-4 alkyloxycarbonyl,hydroxycarbonyl, substituted or unsubstituted phenyl and a substituted or unsubstituted C 1-14 heterocycle; aryl, as a group or part of a group, is naphthyl or phenyl each of which may optionally be substituted with one or more substituents selected from trifluoromethyl, trifluoromethyloxy, halo, cyano, nitro, C 1-12 alkyl, C 1-12 alkyloxy, phenylC 1-6 alkyl, phenylC 1-6 alkyloxy, phenyloxy, phenylcarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl, amino, mono- or di(C 1-4 alkyl)amino, mono- or di(C 1-4 alkyl)amino wherein said C 1-4 alkyl is substituted with one or more substituted or unsubstituted phenyl, S(O) 2 —R 7 , C 1-6 alkylcarbonylamino, substituted or unsubstituted phenyl, and a substituted or unsubstituted C 1-14 heterocycle.