Patent ID: 8247443

Claim:
A small molecule characterized by its ability to bind to a Gram-negative bacterial LuxN receptor at the autoinducer-1 (AI-1) binding site of LuxN, wherein said small molecule is represented by the formula: wherein X is O or S; n is 0, 1 or 2; Y is O, S or CH 2 ; wherein the aryl ring substituent Z represents single or multiple substituents, wherein when Z represents a single substituent Z is located at the ortho, meta or para position, when Z represents multiple substituents, the substituents are located at any combination of the ortho, meta or para positions, and wherein Z is selected from the group consisting of halogen, hydroxyl, alkoxyl, cyano, nitro, amido, acetamido, amino, alkylamino, aryl, heteroaryl, acyl, alkyl, cycloalkyl, sulfonamide, and alkyl sulfonamide.