Patent ID: 8303954

Claim:
A humanized antibody which does not bind to an amyloid β protein monomer and binds to an amyloid β oligomer, and which comprises the following (a) antibody heavy chain variable region and (b) antibody light chain variable region: (a) an antibody heavy chain variable region comprising the amino acid sequence represented by SEQ ID NO:12 or an amino acid sequence in which at least one modification among amino acid modifications for substituting Leu at position 18 with Arg, Gln at position 46 with Glu, Met at position 48 with Val, Val at position 49 with Ala, Ser at position 77 with Asn, Val at position 93 with Met, and Arg at position 98 with Gly is carried out in the amino acid sequence represented by SEQ ID NO:12, (b) an antibody light chain variable region comprising the amino acid sequence represented by SEQ ID NO:14 or an amino acid sequence in which at least one modifications among amino acid modifications for substituting Ile at position 2 with Val, Val at position 3 with Leu, Pro at position 15 with Leu, Gln at position 50 with Lys, and Gln at position 105 with Gly is carried out in the amino acid sequence represented by SEQ ID NO:14.