Patent ID: 8399671

Claim:
A method for preparing a compound of Formula III from a compound of Formula I: the method comprising contacting the compound of Formula I and a hydrazide reagent of Formula II in a first reaction mixture for at least 6 hours, to convert the compound of Formula I to the compound of Formula III, wherein: R 1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted allyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted aryl sulfonyl, substituted or unsubstituted alkyl sulfonyl, substituted or unsubstituted acyl, substituted or unsubstituted formyl, hydroxyl, substituted or unsubstituted carboxyester, and substituted or unsubstituted carboxyamide; R 2 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted acyl, substituted or unsubstituted aryl sulfonyl, substituted or unsubstituted alkyl sulfonyl, substituted or unsubstituted carboxyester, substituted or unsubstituted carboxyamide, substituted or unsubstituted trialkylsilyl, substituted or unsubstituted heterocycloalkyl; R 3 is selected from the group consisting of substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted acyl, substituted or unsubstituted aryl sulfonyl, substituted or unsubstituted alkyl sulfonyl, substituted or unsubstituted carboxyester, substituted or unsubstituted carboxyamide, substituted or unsubstituted trialkylsilyl, substituted or unsubstituted heterocycloalkyl; R 8 and R 9 are independently selected from the group consisting of hydrogen, hydroxyl, and substituted or unsubstituted hydrocarbyl, or R 8 and R 9 together form a carbonyl group; R 10 , R 11 , R 14 and R 15 are independently selected from the group consisting of hydrogen, substituted and unsubstituted hydrocarbyl, and a halogen, or R 14 and R 15 together form a carbonyl group; R 16 is selected from the group consisting of hydrogen, and substituted or unsubstituted hydrocarbyl; and, R 18 is either an acyl group having the formula R 19 —C(O)— or a sulfonyl group having the formula R 20 —S(O) 2 —, wherein R 19 and R 20 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and substituted or unsubstituted heteroaryl.