Patent ID: 7550146

Claim:
A glycoconjugate having the structure: wherein n′is 1, 2, or 3; p′is 1, 2, 3, or 4; Rc, for each occurrence, is independently hydrogen or a substituted or unsubstituted linear or branched lower alkyl; each occurrence of R B is methyl; each occurrence of R A is independently a carbohydrate domain having the structure: wherein a, b, c, d, e, f, g, h, i, x, y and z are each independently 0, 1, 2 or 3, with the proviso that R A , for each occurrence, is independently a carbohydrate comprised of furanose or pyranose moieties, whereby the sum of b and c is 1 or 2 , the sum of d and f is 1 or 2, and the sum of g and i is 1 or 2, and with the proviso that x, y and z are not simultaneously 0; wherein R 0 is a hydrogen, linear or branched chain alkyl, acyl, arylalkyl or aryl group; wherein each occurrence of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 is independently hydrogen, OH, OR 1 , NH 2 , NHCOR 1 , F, CH 2 OH, CH 2 OR i , a substituted or unsubstituted linear or branched chain alkyl, (mono-, di- or tri)hydroxyalkyl, (mono-, di- or tri)acyloxyalkyl, arylalkyl, or aryl group; wherein each occurrence of R i is independently hydrogen, CHO, CO 2 R ii a substituted or unsubstituted linear or branched chain alkyl, arylalkyl, or aryl group, or a saccharide moiety having the structure: wherein Y and Z are independently NH or O; wherein k, l, r, s, t, u, v and w are each independently 0, 1 or 2, with the proviso that the v and w bracketed structures represent furanose or pyranose moieties and the sum of 1 and k is 1 or 2, and the sum of s and u is 1 or 2, and with the proviso that v and w are not simultaneously 0; wherein R′ 0 is hydrogen, a linear or branched chain alkyl, acyl, arylalkyl or aryl group; wherein each occurrence of R 10 , R 11 , R 12 , R 13 , R 14 and R 15 is independently hydrogen, OH, OR iii , NH 2 , NHCOR iii , F, CH 2 OH, CH 2 OR iii , or a substituted or unsubstituted linear or branched chain alkyl, (mono-, di- or tri)hydroxyalkyl, (mono- di- or tri-) acyloxyalkyl, arylalkyl or aryl group; wherein R 16 is hydrogen, CO 2 H, CO 2 R ii , CONHR ii , a substituted or unsubstituted linear or branched chain alkyl or aryl group; wherein each occurrence of R iii is independently hydrogen, CHO, CO 2 R iv , or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group; and wherein each occurrence of R ii and R iv is independently hydrogen, or a substituted or unsubstituted linear or branched chain alkyl, acyl, arylalkyl or aryl group; with the limitation that each occurrence of R A independently comprises a carbohydrate domain, or truncated or elongated version thereof, that is present on tumor cells.