Patent ID: 7217711

Claim:
A compound formula (I): wherein R 1 denotes a heteroaryl-C 1-3 -alkyl group, where the term heteroaryl denotes a pyridinyl, pyrimidinyl, phenylpyridinyl, phenylpyrimidinyl, benzoxazolyl, 1-methyl-1H-benzotriazolyl, benzo[1,2,5]thiadiazolyl, [1,2,4]triazolo[4,3-a]pyridinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, or naphthyridinyl group, and each heteroaryl group is substituted by R 10 and R 11 , where R 10 denotes a fluorine, chlorine or bromine atom or a difluoromethyl, trifluoromethyl, cyano, methoxy, difluoromethoxy, trifluoromethoxy, amino, methylamino, dimethylamino, pyrrolidin-1-yl, piperidin-1-yl or morpholin-4-yl group, and R 11 denotes a methoxy or cyano group or R 1 denotes a naphthyl-C 1-3 -alkyl group wherein the naphthyl moiety is substituted by R 13 wherein R 13 denotes a difluoromethyl, trifluoromethyl, difluoromethoxy or trifluoromethoxy group, R 2 denotes a hydrogen atom or a methyl group, R 3 denotes a 2-butyn-1-yl group or a 1-buten-1-yl, 2-buten-1-yl or 3-methyl-2-buten-1-yl group, and n denotes the number 1 or 2, or a tautomer, enantiomer, diastereomer, mixture or salt thereof, with the exception of the compounds: 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(pyridin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(pyridin-3-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(pyridin-4-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(2-methoxy-pyridin-3-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(6-amino-pyridin-3-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(5-amino-pyridin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(2-fluoro-pyridin-3-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(2-fluoro-pyridin-4-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(6-fluoro-pyridin-2-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 2-(piperazin-1-yl)-3-(butyn-1-yl)-5-[(isoquinolin-1-yl)methyl]-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one.