Patent ID: 7595063

Claim:
A process for the preparation of a drug loaded compressed tablet containing about 50% efavirenz comprising the following steps: (a) blending efavirenz with a filler/disintegrant, superdisintegrant, binder and surfactant; (b) adding at least 1.1% by weight of water per weight of efavirenz to wet granulate the blended mixture to agglomerate the mixture; (c) drying the granulated mixture to a moisture content of about 0% to about 10%; (d) milling the dried mixture to granulate to a uniform size; (e) blending the milled mixture with a filler/compression aid; (f) lubricating the blended mixture with a lubricant; and (g) compressing the lubricated mixture to a compressed tablet of the desired shape; wherein the superdisintegrant is croscarmellose sodium and has a concentration in the tablet between about 1% to about 5% by weight.