Patent ID: 8623844

Claim:
A process for the preparation of dibenzyl{3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl}-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid of formula (II), the process comprising: a) providing a solution of dibenzyl {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl}-5-oxo-4,5-dihydro-[1,2,4]-triazolyl}phosphonic acid in a solvent or a mixture of solvents; b) adding an anti-solvent to the solution of (a); c) recovering dibenzyl {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl}-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid as a crystalline compound.