Patent ID: 7700717

Claim:
A backbone cyclized analog of somatostatin having the general Formula No. 1 Z-Q-PTR Formula No. 1 wherein Z is a photo-active moiety selected from the group consisting of 5-(4-((oxocarbonyl)methyl)phenyl)-10,15,20-triphenyl-21,23H-porphyrin; 5-(4-carboxyphenyl)-10,15,20-triphenyl-21,23H-porphyrin; 5-(4-((aminocarbonyl)methyl)phenyl)-10,15,20-triphenyl-21,23H-porphyrin; 5-(4-((oxocarbonyl)methyl)phenyl)-10,15,20-triphenyl-21,23H-chlorine (mixed isomers); 5-(aminothionyl)fluorescein; 4-sulfonyl-2-sulfo-rhodamine B; 2-sulfonyl-4-sulfo-rhodamine B (mixed isomers); and 5- and 6-carboxyfluorescein (mixed isomers); Q comprises a covalent bond selected from the group consisting of amide, carbamate, urea, thiourea, amine, and sulfonamide and PTR is selected from the group consisting of: DPhe-Cys*-Phe-Trp-DTrp-Lys-Thr-Phe-GlyS2*-NH 2 (SEQ ID NO: 1) denoted PTR 3207; GlyS2*-Phe-Trp-DTrp-Lys-Thr-Phe-GlyS2*-NH 2 (SEQ ID NO: 2) denoted PTR 3213; DPhe-GlyS2*-Phe-Trp-DTrp-Lys-Thr-Phe-GlyS2*-NH 2 (SEQ ID NO: 3) denoted PTR 3219; and GABA*-Phe-Trp-DTrp-Lys-Thr-Phe-GlyC3*-NH 2 (SEQ ID NO: 4) denoted PTR 3173; and wherein the asterisks denote the cyclization points.