Patent ID: 7435743

Claim:
A pyridine derivative of the formula (I) wherein —R 1 represents in which R 11 is hydrogen, C 1-6 alkyl, halogen, hydroxy, C 1-12 alkoxy, nitro, amino, C 1-6 alkylsulfonylamino, C 1-6 alkoxycarbonyl, C 1-6 alkylamino, di (C 1-6 alkyl)amino, C 1-6 alkanoylamino, phenyl C 1-6 alkylamino, phenylsulfonylamino, or —O—(CH 2 ) n —R 111 , wherein n represents an integer selected from 0 to 6, and R 111 is C 2-6 alkenyl, benzoyl, diphenylmethyl, di (C 1-6 alkyl)amino, C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, or a 3 to 10 membered saturated or unsaturated ring having 0 to 3 heteroatoms selected from the group consisting of S, O and N as heteroatoms and is optionally substituted by C 1-6 alkyl, mono or di halogen, halogen substituted C 1-6 alkyl, nitro, cyano, C 1-6 alkoxycarbonyl, phenyl, hydroxy, amino, C 1-6 alkylamino, di (C 1-6 alkyl)amino, C 1-6 alkanoylamino, C 1-6 alkoxy, or carbamoyl; R 2 represents hydrogen or halogen; R 3 represents hydrogen or, —CR 31 R 32 R 33 , wherein R 31 is hydrogen or C 1-6 alkyl, R 32 is hydrogen, α-aminobenzyl, C 1-6 alkyl optionally substituted by one or two substituents selected from the group consisting of hydroxy, amino, amino substituted phenyl, phenyl, halogen substituted phenyl, and C 1-6 alkoxysubstituted phenyl, or a 5 to 8 membered saturated ring having 0 to 3 atoms selected from the group consisting of S, O and N as heteroatoms and optionally substituted by C 1-6 alkyl, and R 33 is hydrogen, amino, C 1-6 alkoxycarbonylamino, C 2-6 alkenyloxycarbonylamino, or piperidino-C 1-6 alkylcarbonylamino, or R 4 represents hydroxycarbonyl, C 1-6 alkanoyl, carbamoyl, cyano, nitro, carboxyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbamoyl, C 1-6 alkylamino, 5 to 10 membered heteroaryl (hydroxy) methyl, 5 to 10 membered heteroaryl-C 1-6 alkyl, or methyl substituted by hydroxy and a 5 to 7 membered saturated cyclic ring, C 1-6 alkyl optionally substituted by one selected from the group consisting of hydroxy, C 1-6 alkoxy, C 1-6 alkylsulfonylamino, C 1-6 alkylcarbonylamino, C 5-10 aryl, C 5-10 arylsulfonyl, C 5-10 arylsulfanyl, C 5-10 aryloxy, imidazolyl, or dioxo substituted pyrolidino-oxy, —(CH 2 ) p NHCOR 41 , —(CH 2 ) p NHC(═S)R 41 wherein p represents any of integer from 1 to 6 and R 41 represents C 1-6 alkoxy, amino, phenylamino, C 1-6 alkyl, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 3-10 cycloalkylamino, R 5 represents NR 51 R 52 , wherein R 51 is hydrogen, C 1-6 alkyl, R 52 is hydrogen, C 1-6 alkyl, phenyl, benzyl, C 1-6 alkanoyl, or NR51 R52 may form saturated 5-6 membered ring optionally contain NH or O as other heteroatom than the adjacent N atom, or a salt thereof.