Patent ID: 8399623

Claim:
An isolated human monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody binds human mesothelin and exhibits at least one, two, three, four or all five of the following properties: (a) binds to human mesothelin with a K D of 1×10 −8 M or less; (b) is internalized by mesothelin-expressing cells; (c) inhibits binding of mesothelin to ovarian cancer antigen CA125; (d) exhibits antibody dependent cellular cytotoxicity (ADCC) against mesothelin-expressing cells; or (e) inhibits growth of mesothelin-expressing cells in vivo when conjugated to a cytotoxin; said isolated human monoclonal antibody, or antigen-binding portion thereof comprising (i) a heavy chain variable region CDR1 comprising SEQ ID NO:1; (ii) a heavy chain variable region CDR2 comprising SEQ ID NO:4; (iii) a heavy chain variable region CDR3 comprising SEQ ID NO:7; (iv) a light chain variable region CDR1 comprising SEQ ID NO:10; (v) a light chain variable region CDR2 comprising SEQ ID NO:13; and (vi) a light chain variable region CDR3 comprising SEQ ID NO:16.