Patent ID: 8546547

Claim:
A polymer conjugate comprising a polypeptide variant of the human and/or non human HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A, whereby the amino acid sequence of said polypeptide variant differs from the amino acid sequence of the wild type HMGB1 Box-A by the mutation of one or more single amino acid, wherein the polypeptide variant of the human HMGB1 Box-A is selected from the group consisting of amino acid sequences defined by SEQ ID NO: 35, 43, 57, 64, 69, and 104, and at least one linear or branched polymer moiety selected from the group consisting of polyalkylene glycol, polyalkylene oxide, polyacrylic acid, polyacrylate, polyacrylamide, N-alkyl polyacrylate derivatives, polymethacrylic acid, polymethacrylate, polyethylacrylic acid, polyethylacrylate, polyvinylpyrrolidone, poly (vinylalcohol), polyglycolic acid, polyactic acid, poly(lactic-co-glycolic) acid, dextran, chitosan and polyaminoacid.