Patent ID: 8796437

Claim:
An oligomeric compound having from 8 to 40 linked monomeric subunits comprising: at least one tetrahydropyran nucleoside analog having one of Formulas Ib or Ic: wherein independently for each tetrahydropyran nucleoside analog of said formula: Bx is a heterocyclic base moiety; X is O or S; T 6 is H, a hydroxyl protecting group, a 5′ or 3′-terminal group or an internucleoside linking group linking the tetrahydropyran nucleoside analog to at least one of said monomer subunits; T 7 is at least one of said monomer subunits; X is O or S; and at least one modified nucleoside wherein each of said at least one modified nucleoside is, independently, selected from a bicyclic nucleoside, a 2′-modified nucleoside, a 4′-thio modified nucleoside and a 4′-thio-2′-modified nucleoside; wherein said oligomeric compound is hybridizable to at least a portion of a target nucleic acid.