Patent ID: 8354392

Claim:
A drug-introduced photo-reactive hyaluronic acid derivative which comprises a photo-reactive group and a drug both being bound to hyaluronic acid through covalent bonds via a first and second spacer, respectively, wherein the photo-reactive group is a cinnamic acid, the drug is a non-steroidal anti-inflammatory drug or an anti-rheumatic drug, each of the first and second spacers are a residue of an amino alcohol, the photo-reactive group and the drug are each bonded to one of the first and second spacers through an ester bond and each of said first and second spacers bonded to the photo-reactive group and the drug is bonded to a carboxyl group of the hyaluronic acid through an amide bond and the drug-introduced photo-reactive hyaluronic acid derivative is soluble in an aqueous medium.