Patent ID: 6900219

Claim:
A method of treating a disease state or condition in a mammal that is alleviable by treatment with an agent capable of increasing ABCA-1 expression, comprising administering to a mammal in need thereof a therapetically effective dose of a compound of the Formula I: wherein: R 1 , R 2 , R 3 and R 4 are independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted cycloalkyl, acyl, acylamino, acyloxy, optionally substituted amino, aminocarbonyl, cyano, halogen, hydroxy, carboxy, carboxyalkyl, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heteroaryl, optionally substituted heterocyclyl, SO 2 NR a R b , —SO-alkyl, —SO-aryl, —SO-heteroaryl, —SO 2 -alkyl, SO 2 -aryl, and trifluoromethyl; in which R a and R b are independently hydrogen, lower alkyl, or cycloalkyl; R 5 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R 6 is hydrogen, optionally substituted alkyl, or optionally substituted cycloalkyl; R 7 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R 8 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; X is independently oxygen or sulfur; and Y is oxygen or —NR 9 , in which R 9 is hydrogen or lower alkyl.