Patent ID: 7960584

Claim:
A compound of the formula (Ia), or an isomer or pharmaceutically acceptable salt thereof; wherein, X is CR 11 ═CR 12 , or C≡C, wherein, R 11 and R 12 are independently hydrogen, halogen, C1-C5 alkyl, or phenyl; R 1 and R 2 are independently hydrogen, carboxy, C1-C5 alkyl, halogen, nitro, C1-C5 alkoxy, halo (C1-C5) alkyl, C1-C5 alkylcarbonyl, C1-C5 alkylcarbonylamino, C1-C5 alkylsulfonylamino, phenylsulfonylamino, C1-C5 alkylthio, C1-C5 alkylsulfonyl, or C1-C5 alkoxycarbonyl; R 3 is hydrogen, C1-C5 alkyl, C1-C5 alkoxy, or halo (C1-5)alkyl; R 4 , R 5 , R 6 , R 7 , and R 8 are independently hydrogen, carboxy, C1-C5 alkyl, nitro, C2-C5 alkenyl, C1-C5 alkoxy, C2-C5 alkynyl, halo (C1-C5) alkyl, C1-C5 alkylthio, C1-C5 alkylsulfonyl, C1-C5 alkyl carbonyl, C1-C5 alkoxycarbonyl, phenyl, or halogen, wherein, phenyl may be unsubstituted or substituted with one or more substituent selected from carboxy, C1-C5 alkyl, halogen, nitro, C2-C5 alkenyl, C1-C5 alkoxy, halo (C1-C5) alkyl, C1-C5 alkyl carbonyl, C1-C5 alkylthio, C1-C5 alkylsulfonyl, or C1-C5 alkoxy carbonyl; R 9 is C1-C5 alkylsulfonyl or C2-C5 alkenylsulfonyl; and R 10 is hydrogen; provided that if R 3 is different from hydrogen, then R 11 and R 12 are not simultaneously hydrogen.