Patent ID: 8916611

Claim:
A method for treating back or neck pain with or without radiculopathy comprising locally delivering a depot, wherein the depot comprises a bolus of microbubbles comprising a biopolymer containing polylactide and a therapeutic agent to a disc region comprising a disc, the therapeutic agent adapted to disrupt a neuronal element in the disc region, wherein the therapeutic agent comprises 2,3,4-Trihydroxy-6-methyl-5-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]benzaldehyde (Scutigeral); ReN-1820 for reducing the levels of NGF that can bind to NGF receptors found on neuronal elements; and a synthetic neurotoxin; and subjecting the bolus of microbubbles to sonic energy to activate the therapeutic agent within the disc region.