Patent ID: 7491847

Claim:
A process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan having the structure wherein R 1 is H, hydroxyl, alkoxy or wherein Y is O or S; R 2 and R 3 is each, independently, C 1-8 alkyl, C 6-12 aryl, C 6-12 aralkyl, each optionally halo substituted, or hydrogen; where the reaction mixture further comprises a solvent, a primary aminoindan having the structure wherein R 1 is defined as above, and a tertiary aminoindan having the structure the process comprising a) adding an acid to the reaction mixture; b) crystallizing the mono-propargylated aminoindan under conditions suitable for the formation of a crystalline salt of the mono-propargylated aminoindan; and c) recovering the crystalline salt of the mono propargylated aminoindan, wherein the process is performed without addition of an organic solvent.