Patent ID: 8207168

Claim:
A compound according to formula Ie: or a stereoisomeric form, mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof; wherein: R 1 is selected from a piperidinyl or pyrrolidinyl ring, optionally substituted with 1 to 3 R 20 groups; R 12 is H, C 1 -C 6 alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, C(═O)R 27 , or CO 2 R 27 , wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heterocycloalkyl group is optionally substituted with 1 to 3 R 20 groups; R 13 and R 14 are each independently H, C 1 -C 6 alkyl, aryl, arylalkyl C 1 -C 6 alkoxyl, S(═O) y —C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, or heteroaryl; or R 13 and R 14 , are taken together with the carbon atoms through which they are connected to form a fused phenyl, thienyl, pyrrolyl, oxazolyl, pyridinyl, cyclopentyl or cyclohexyl ring, wherein the fused phenyl, thienyl, pyrrolyl, oxazolyl, pyridinyl, or cyclopentyl or cyclohexyl ring ring is optionally substituted with 1 to 3 R 20 groups; R 20 at each occurrence is independently, H, F, Cl, Br, I, OR 21 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 -C 6 alkyl optionally substituted with OR 26 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkylC 0 -C 4 alkyl, 3- to 7-membered heterocycloalkylC 0 -C 4 alkyl, phenyl, 5- or 6-membered heteroarylC 0 -C 4 alkyl, arylalkyl, (═O), C(═O)R 21 , CO 2 R 21 , OC(═O)R 21 , C(═O)NR 23 R 24 , NR 27 C(═O)R 21 , NR 27 C(═O)OR 21 , OC(═O)NR 23 R 24 , NR 27 C(═S)R 21 , or S(O) q R 21 ; each R 21 is independently H, C 1 -C 6 alkyl, aryl, or arylalkyl; each R 23 and R 24 is independently selected from H, C 1 -C 6 alkyl, and aryl, or R 23 and R 24 , together with the nitrogen atom to which they are attached, form a 3 to 7 membered heterocyclic ring optionally substituted with ═O; R 26 is H, C 1 -C 6 alkyl, aryl, or alkylaryl; and R 27 is H, or C 1 -C 6 alkyl.