Patent ID: 7250414

Claim:
A compound of formula I: wherein: each R 1 and R 2 are independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR a , —SR a , —NR a R b , —S(O)R c and —S(O) 2 R c ; where each R a and R b independently represents hydrogen, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl or (3-6C)cycloalkyl; each R c independently represents (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl or (3-6C)cycloalkyl; or two adjacent R 1 groups or two adjacent R 2 groups are joined together to form (3-6C)alkylene, (2-4C)alkylene-O— or —O—(2-4C)alkylene-O—; a and b each independently are 0 or an integer of from 1 to 5; each R 3 independently is fluoro or (1-4C)alkyl; c is 0 or an integer of from 1 to 3; R 4a and R 4b are independently selected from hydrogen, (1-4C)alkyl and phenyl-(1-4C)alkyl; or R 4a and R 4b together with the carbon atom to which they are attached form a (3-6C)heterocyclic ring optionally containing one additional heteroatom selected from nitrogen, oxygen or sulfur and wherein the heterocyclic ring is unsubstituted or substituted with 1 or 2 substituents selected independently from (1-4C)alkyl and fluoro; e is 1; m is 1, 2, 3 or 4; Ar 1 represents a phenylene group or a (3-5C)heteroarylene group containing 1 or 2 heteroatoms selected independently from oxygen, nitrogen or sulfur; wherein the phenylene and heteroarylene groups are unsubstituted or substituted with 1 to 4 substituents selected independently from halo, (1-4C)alkyl or (1-4C)alkoxy; wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; n is 0, 1, 2, 3 or 4; provided that the values of m, n and Ar 1 are selected such that the number of contiguous atoms in the chain —(CH 2 ) m —Ar 1 —(CH 2 ) n — between the two nitrogen atoms to which it is attached is in the range of from 7 to 12; R 5 is selected from hydrogen, (1-6C)alkyl, Ar 2 , —CH 2 Ar 2 and —CH 2 CH 2 NHC(O)R 5a ; where Ar 2 represents phenyl, (3-6C)cycloalkyl or (3-5C)heteroaryl containing 1 or 2 heteroatoms selected from oxygen, nitrogen or sulfur, wherein the phenyl and heteroaryl groups are unsubstituted or substituted with 1 to 3 substituents selected independently from halo, (1-4C)alkyl, (1-4C)alkoxy and methylenedioxy; and wherein R 5a represents (1-4C)alkyl; R 6 is hydrogen or (1-6C)alkyl; or R 5 and R 6 together with the nitrogen atom to which they are attached form a (3-5C)azacycloalkyl group; or when Ar 1 represents heteroarylene, R 5 and R 6 together with the nitrogen atom to which they are attached can additionally form a morpholin-1-yl or 4-(1-6C)alkylpiperazin-1-yl group; and wherein each alkyl group in R 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 6 and R a-c is optionally substituted with from 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or solvate or stereoisomer thereof.