Patent ID: 8618053

Claim:
A multimer comprising at east a first and a second chain, the first chain comprising: (a.1) the polypeptide of SEQ ID NO:4, wherein (i) the leucine at position 98 is substituted with an arginine; (ii) the proline at position 171 is substituted with glycine; and (iii) the alanine at position 180 is substituted with glutamic acid; (b.1) a linker sequence comprising SEQ ID NO:31; and (c.1) an Fc domain comprising SEQ ID NO:11; and the second chain comprising: (a.2) the polypeptide of SEQ ID NO:4, wherein (i) the leucine at position 98 is substituted with an arginine; (ii) the proline at position 171 is substituted with glycine; and (iii) the alanine at position 180 is substituted with glutamic acid; (b.2) a linker sequence comprising SEQ ID NO:31; and (c.2) an Fc domain comprising SEQ ID NO:11.