Patent ID: 8178578

Claim:
A method for producing a vascular damaging effect in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an effective amount of a compound represented by Formula I: or a pharmaceutically acceptable salt thereof wherein: R 1 , R 2 and R 3 each independently represent (1-4C)alkoxy; Q 1 , Q 2 , Q 3 and Q 4 each independently represent hydrogen, halogeno, hydroxy, cyano, nitro, trifluoromethyl, thiol, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, amino, (1-4C)alkylamino, di-[(1-4C)alkyl]amino, (1-4C)alkylthio, (1-4C)alkylsulfonyl, (1-4C)alkylsulfonyloxy, an alkali metal phosphato group, or a group of the formula: NR 4 —C(O)—[C(R 5 )(N{R 6 } 3 + (X n− ) 1/n ]—C(R 7 ) 2 (OH) wherein R 4 , R 5 , R 6 and R 7 each independently represent hydrogen, (1-4C)alkyl, (2-4C)alkenyl or (2-4C)alkynyl, X n− represents a suitable anion and n is 1 or 2, or a group of the formula: —BR 8 R 9 wherein R 8 and R 9 each independently represent hydrogen, hydroxy or (1-4C)alkoxy, or any one of Q 2 and Q 3 or Q 3 and Q 4 represents a methylenedioxy group; and wherein any CH 2 or CH 3 group within a R 1 , R 2 , R 3 , Q 1 , Q 2 , Q 3 and/or Q 4 substituent optionally bears on each said CH 2 or CH 3 group one or more halogeno or hydroxy substituents, provided that when Q 1 represents hydrogen or methoxy and Q 4 represents hydrogen, then Q 2 and Q 3 do not both represent methoxy.