Patent ID: 7943170

Claim:
A pharmaceutical composition comprising a bilayer tablet having an immediate release phase of paracetamol and a sustained release phase of paracetamol, the immediate release phase being in one layer and comprising from about 25 to 35% by weight of the total paracetamol; and the sustained release phase being in the other layer, and the sustained release layer comprising paracetamol comprising from about 65 to 75% by weight of the total paracetamol in admixture with a matrix forming water soluble polymer which is selected from two different viscosities of hydroxypropylmethylcellulose present in an amount from 0.5 to 10% by weight of the sustained release phase and wherein the hydroxypropylmethylcellulose is present as a low viscosity hydroxypropylmethylcellulose and a high viscosity hydroxypropylmethylcellulose in a ratio of about 1:2; said composition comprising from 600 to 700 mg of paracetamol per unit dose and a pharmaceutically acceptable carrier, characterised in having an in vitro paracetamol dissolution profile (as determined by the USP type III apparatus, reciprocating basket, with 250 ml of 0.1M HCl at 37° C. set at a cycle speed of 15 strokes/min) with the following constraints: 30 to 48% released after 15 minutes 56 to 75% released after 60 minutes >85% released after 180 minutes.