Patent ID: 8715678

Claim:
A method for treating a cell to inhibit the histone 3 lysine 4 of (H3K4) methylation activity of a Suppressor of variegation Enhancer of Zeste, Trithorax (SET1) protein family core complexes comprising the steps of exposing a cell to a peptide; wherein the cell comprises both a tryptophan-aspartic acid repeat 5 (WDR5) and a SET1 family protein, wherein the WDR5 and SET1 family protein are components of a SET1 family core complex that has H3K4 activity when exposed to histone protein H3, the WDRH5 having a SET receptor site (N-SET) that is N-terminal to a SET domain; wherein the peptide has a primary structure consisting of a cell penetration sequence and an inhibitory motif with a 3 10 -helix, the inhibitory motif having twenty or fewer residues including: (SEQ ID NO. 7) GX 1 ARX 2 where X 1 = S, C or A X 2 = A, S or T allowing the peptide to inhibit the formation of the SET1 family core complex, the inhibition being relative to an identical sample that lacks the peptide.