Patent ID: 8835571

Claim:
A conjugate comprising a fatty acid derivative and an alkyl substituted polylactide compound, wherein the fatty acid derivative is represented by the formula (I): wherein L, M and N are hydrogen, hydroxy, halogen, straight or branched C1-6 alkyl, hydroxy(straight or branched C1-6)alkyl, straight or branched C1-6 alkanoyloxy or oxo, wherein at least one of L and M is a group other than hydrogen, and the double bond in the five-membered ring is optional; A is —CH 3 , or —CH— 2 OH, —COCH 2 OH, —COOH or a functional derivative thereof; B is single bond, —CH 2 —CH 2 —, —CH═CH—, —C≡C—, —CH 2 —CH 2 —CH 2 —, —CH═CH—CH 2 —, —CH 2 —CH═CH—, —C≡C—CH 2 — or —CH 2 —C≡C—; Z is or single bond wherein R 4 and R 5 are hydrogen, hydroxy, halogen, straight or branched C1-6 alkyl, straight or branched C1-6 alkoxy or hydroxy(straight or branched C1-6)alkyl, wherein R 4 and R 5 are not hydroxy and straight or branched C1-6 alkoxy at the same time; R 1 is a saturated or unsaturated bivalent straight or branched C1-14 aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, straight or branched C1-6 alkyl, hydroxy, oxo, aryl or heterocyclic group, and at least one of carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; Ra is a saturated or unsaturated straight or branched C1-14 aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, oxo, hydroxy, straight or branched C1-6 alkyl, straight or branched C1-6 alkoxy, straight or branched C1-6 alkanoyloxy, cyclo(straight or branched C3-6)alkyl, cyclo(straight or branched C3-6)alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic-oxy group; straight or branched C1-6 alkoxy; straight or branched C1-6 alkanoyloxy; cyclo(straight or branched C3-6)alkyl; cyclo(straight or branched C3-6)alkyloxy; aryl; aryloxy; heterocyclic group; heterocyclic-oxy group, and at least one of carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; and provided that Z is C═O and/or B is —CH 2 —CH 2 —.