Patent ID: 6989153

Claim:
An unpolymerized ionizing radiation sensitive liposome delivery system at room temperature, produced by the method of: (i) selecting a stable liposome-forming lipid or lipids, and an ionizing radiation polymerizable colipid or colipids, wherein said polymerizable colipid comprises a polymerizable group selected from the group consisting of diacetylenyl, acryloyl, methacryloyl, dienoyl, dienyl, sorbyl, muconyl, styryl, vinyl, and lipoyl; (ii) drying the lipids and colipids that comprise the liposome; (iii) hydrating said lipids and colipids with a buffer comprising releasable agents to be encapsulated or associated in a desired molar ratio to form liposomes at a temperature which enables the colipids to cluster in discrete domains in said liposomes; and (iv) purifying the liposomes, wherein after administration to a patient the colipids in said liposomes remain clustered in discrete domains.