Patent ID: 7399749

Claim:
A compound, or enantiomer, stereoisomer, rotamer, tautomer, and racemate of said compound, or a pharmaceutically acceptable salt of said compound, said compound having the general structure shown in Formula I: wherein: Z is selected from the group consisting of a hetero-bicyclic ring system; R 1 is NR 9 R 10 , wherein R 9 and R 10 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, aryl-, heteroalkyl-, heteroaryl-, cycloalkyl-, heterocyclyl-, arylalkyl-, and heteroarylalkyl, or alternately R 9 and R 10 in NR 9 R 10 are connected to each other such that NR 9 R 10 forms a four to eight-membered heterocyclyl, and likewise independently alternately R 9 and R 10 in CHR 9 R 10 are connected to each other such that CHR 9 R 10 forms a four to eight-membered cycloalkyl; R 2 and R 3 can be the same or different, each being independently selected from the group consisting of H, alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl-; Y is selected from the following moieties: wherein G is NH or O; and R 15 , R 16 , R 17 , R 18 , R 19 , R 20 and R 21 can be the same or different, each being independently selected from the group consisting of H, alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, or alternately (i) R 17 and R 18 are independently connected to each other to form a three to eight-membered cycloalkyl or heterocyclyl; (ii) likewise independently R 15 and R 19 are connected to each other to form a four to eight-membered heterocyclyl; (iii) likewise independently R 15 and R 16 are connected to each other to form a four to sight-membered heterocyclyl; and (iv) likewise independently R 15 and R 20 are connected to each other to form a four to eight-membered heterocyclyl; wherein each of said alkyl, aryl, heteroaryl, cycloalkyl or heterocyclyl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, amido, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, sulfonamido, alkyl, aryl, heteroaryl, alkylsulfonamido, arylsulfonamido, keto, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halo, cyano, and nitro.