Patent ID: 7129263

Claim:
A process for preparing a compound of formula wherein X is halogen, —OH, —CN, —C 1 to C 4 alkyl substituted with one to three halogen atom, —NH 2 , —NH(C 1 –C 4 alkyl), —N(C 1 –C 4 alkyl)(C 1 –C 4 alkyl), —C(═O)NH 2 , —C(═O)NH(C 1 –C 4 alkyl), —C(═O)N(C 1 –C 4 alkyl)(C 1 –C 4 alkyl), —NHS(═O) 2 H, or —NHS(═O) 2 R 4 ; R 1 and R 2 are, with the carbon to which they are attached, connected to form a C 3 –C 7 cycloalkyl or a 4–7 membered heterocycloalkyl comprising from one to three hetero moities selected from O, S, —C(═O), and N; and wherein said cycloalkyl or heterocycloalkyl optionally contains one or two double bonds; and wherein said cycloalkyl or heterocycloalkyl is optionally fused or attached to a C 6 –C 14 aryl or 5–14 membered heteroaryl group; R 3 is C 1 –C 4 alkyl which may optionally contain one or two unsaturated bonds, —OH, —CN, —NO 2 , —OC 1 –C 4 alkyl, —NH 2 amide or alkyl substituted amide; and n is one or zero; R 4 is selected from C 1 –C 4 alkyl, -(C 1 –C 4 alkylene)—O—(C 1 –C 4 alkyl), 4-(1-methylimidazole), -(C 1 –C 4 alkylene)—NH 2 , -(C 1 –C 4 alkylene)—NH(C 1 –C 4 alkyl), -(C 1 –C 4 alkylene)—N(C 1 –C 4 alkyl)(C 1 –C 4 alkyl); comprising reacting a compound of formula with a compound of formula in the presence of a reducing agent and an organic solvent.