Patent ID: 8153792

Claim:
A process for manufacturing a compound of formula (I): or a salt thereof, wherein each of R 1 and R 2 is one substituent selected from the group consisting of hydrogen, halogen, a linear or branched alkyl, cycloalkyl group containing from 1 to 10 carbon atoms, trifluoromethyl, alkoxy, cyano, dialkylamino, and a solubilising group, the substituents for R 1 and R 2 being selected independently from one another, m is 0-5 and n is 0-4, R 3 is one of the following (i)-(iii): (i) an aryl group optionally substituted with at least one substituent selected from the group consisting of a halogen, an alkyl group containing from 1 to 10 carbon atoms, trifluoromethyl, cyano and alkoxy; (ii) a heteroaryl group optionally substituted with at least one substituent selected from the group consisting of a halogen, an alkyl group containing from 1 to 10 carbon atoms, trifluoromethyl and alkoxy; (iii) a five-membered ring aromatic heterocyclic group optionally substituted with at least one substituent selected from the group consisting of a halogen, an alkyl group containing from 1 to 10 carbon atoms, trifluoromethyl, and alkoxy; the process comprising: a) cyclizing, at room temperature, a compound of formula (IV): with an intermediate of formula (Int4): wherein Ra can be methyl, trifluoromethyl, isopropyl or a phenyl optionally substituted and R 2 , R 3 and n are as described above, to form a compound of formula (III): wherein R 2 , R 3 and n are as described above; b) reducing the nitro group of said compound of formula (III) to form a compound of formula (II): wherein R 2 , R 3 and n are as described above; and c) coupling, in an aprotic solvent, the compound of formula (II) with a compound of formula (Int5) wherein Rb is a hydroxyl, an alkoxy or a halogen group and R 1 and m are as described above, to form the compound of formula (I).