Patent ID: 7727535

Claim:
An isolated polypeptide comprising SEQ ID NO: 2, provided said polypeptide comprises substitutions K237V and C65S; wherein said polypeptide binds to von Willebrand factor with an affinity that is at least 10-fold higher than a GP1bα polypeptide comprising SEQ ID NO: 1; and wherein said polypeptide has at least one activity selected from the group consisting of: 1) lower affinity binding to alpha thrombin relative to binding to alpha thrombin of a protein sequence with the amino acid sequence of SEQ ID NO: 2; 2) lower aggregation relative to aggregation of a protein sequence with the amino acid sequence of SEQ ID NO: 2; and 3) increased resistance to proteolysis relative to a protein sequence with the amino acid sequence of SEQ ID NO: 2.