Patent ID: 7485654

Claim:
A method of recovering corneal sensitivity after corneal surgery, which comprises administering after corneal surgery and topically to the eye of a patient in need thereof an effective amount of an amide compound represented by the formula (I): wherein Ra is a formula: wherein in the formulas (a) and (b), R is hydrogen, alkyl, or cycloalkyl, cycloalkylalkyl, phenyl or aralkyl, each optionally having substituent(s) on the ring, or a formula: wherein R 6 is hydrogen, alkyl or a formula: —NR 8 R 9 wherein R 8 and R 9 are the same or different and each is hydrogen, alkyl, aralkyl or phenyl, and R 7 is hydrogen, alkyl, aralkyl, phenyl, nitro or cyano, or R 6 and R 7 in combination form a heterocyclic group further optionally containing, in the ring, an oxygen atom, a sulfur atom, or a nitrogen atom optionally having a substituent, R 1 is hydrogen, alkyl, or cycloalkyl, cycloalkylalkyl, phenyl or aralkyl, each optionally having substituent(s) on the ring, or R and R 1 in combination form, together with the adjacent nitrogen atom, a heterocyclic group further optionally containing, in the ring, an oxygen atom, a sulfur atom, or a nitrogen atom optionally having a substituent, R 2 is hydrogen or alkyl, R 3 and R 4 are the same or different and each is hydrogen, alkyl, aralkyl, halogen, nitro, amino, alkylamino, acylamino, hydroxy, alkoxy, aralkyloxy, cyano, acyl, mercapto, alkylthio, aralkylthio, carboxy, alkoxycarbonyl, carbamoyl, mono- or di-alkylcarbamoyl or azido, and A is a formula: wherein R 10 and R 11 are the same or different and each is hydrogen, alkyl, haloalkyl, aralkyl, hydroxyalkyl, carboxy or alkoxycarbonyl, or R 10 and R 11 in combination form cycloalkyl, and l, m, n are each 0 or an integer of 1-3, and in the formula (c), L is hydrogen, alkyl, aminoalkyl, mono- or di-alkylaminoalkyl, tetrahydrofurfuryl, carbamoylalkyl, phthalimidoalkyl, amidino, or a formula: wherein B is hydrogen, alkyl, alkoxy, aralkyl, aralkyloxy, aminoalkyl, hydroxyalkyl, alkanoyloxyalkyl, alkoxycarbonylalkyl, α-aminobenzyl, furyl, pyridyl, phenyl, phenylamino, styryl or imidazopyridyl, Q 1 is hydrogen, halogen, a hydroxyl group, aralkyloxy or thienylmethyl, W is alkylene, Q 2 is hydrogen, halogen, a hydroxyl group or aralkyloxy, X is alkylene, Q 3 is hydrogen, halogen, a hydroxyl group, alkoxy, nitro, amino, 2,3-dihydrofuryl or 5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl, and Y is a single bond, alkylene or alkenylene, a bond shown by a broken line and a solid line in the formula (c) is a single bond or a double bond, and R 5 is hydrogen, a hydroxyl group, alkoxy, alkoxycarbonyloxy, alkanoyloxy or aralkyloxycarbonyloxy, Rb is hydrogen, alkyl, aralkyl, aminoalkyl or mono- or di-alkylaminoalkyl, and Rc is a nitrogen-containing heterocycle optionally having substituent(s), an isomer thereof and/or a pharmaceutically acceptable acid addition salt thereof.