Patent ID: 8461209

Claim:
A sulfonyl malonamide derivative represented by the following formula (I) wherein R 1 is optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-10 cycloalkyl, optionally substituted C 3-10 cycloalkyl C 1-6 alkyl, optionally substituted heterocycle, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted aryloxy C 1-6 alkyl, optionally substituted aryl C 2-6 alkenyl, optionally substituted heteroaryl, optionally substituted heteroaryl C 1-6 alkyl, optionally substituted heteroaryloxy C 1-6 alkyl or optionally substituted heteroaryl C 2-6 alkenyl; one of R 2 and R 3 is a hydrogen atom or a halogen atom, and the other is a halogen atom, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkoxy, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, —(CH 2 ) n —C(O)—NR 5 R 6 (wherein n is an integer of 1 to 6, R 5 and R 6 are the same or different and each is a hydrogen atom, C 1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl, or R 5 and R 6 optionally form optionally substituted cyclic amino together with a nitrogen atom bonded thereto), optionally substituted C 3-10 cycloalkyl, optionally substituted heterocycle, optionally substituted C 3-10 cycloalkyl C 1-6 alkyl, optionally substituted heterocycle C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted aryloxy C 1-6 alkyl, optionally substituted aryl C 2-6 alkenyl, optionally substituted heteroaryl, optionally substituted heteroaryl C 1-6 alkyl, optionally substituted heteroaryloxy C 1-6 alkyl or optionally substituted heteroaryl C 2-6 alkenyl, or R 2 and R 3 optionally form, together with a carbon atom bonded thereto, C═CX′Y′ (wherein X′ and Y′ are the same or different and each is a hydrogen atom, optionally substituted C 1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl), or optionally substituted C 3-10 cycloalkyl; and R 4 is the following formula wherein R 7 and R 8 are the same or different and each is a hydrogen atom, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl C 1-6 alkyl, optionally substituted C 3-10 cycloalkyl or optionally substituted heterocycle, or R 7 and R 8 optionally form optionally substituted cyclic amino together with a nitrogen atom bonded thereto, or a pharmacologically acceptable salt thereof.