Patent ID: 8003078

Claim:
A composition which comprises a chelating moiety, said chelating moiety linked to a spacer, which spacer is attached, distal to the chelating moiety, to a nanoparticle having a fluorocarbon core coated with a lipid surfactant, or a pharmaceutically acceptable salt of the chelating moiety; wherein said chelating moiety is of the formula: wherein each n is independently 1-3, and wherein each X is independently O, OH, N, NH or NH 2 as mandated by the position of X in said formulas, and wherein at least one H in said formula (1), (2) or (3) is replaced by a substituent of formula (6): wherein A is an optionally substituted alkylene (1-5C) and Y is unsubstituted alkyl (1-8C) or (CH 2 ) m COOR″ wherein m is 1-8 and R″ is H, alkyl, alkenyl or aryl, and wherein one H in said formula (1), (2) or (3) is replaced by said spacer; and wherein said nanoparticle further comprises a targeting ligand.