Patent ID: 8859776

Claim:
A compound of Formula 1: or a pharmaceutically acceptable salt thereof, wherein: R 1 is: wherein: E is either present or absent, and when present is selected from the group consisting of H, halo, OH, CN, —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, —C(O)OH, —C(O)NR 8 R 8′ , —(C 1 -C 6 )alkyl-C(O)OH, —(C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-C(O)NR 8 R 8′ , —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, heterocyclyl, and heteroaryl; each J independently is selected from the group consisting of H and halogen; Y and R may or may not be present, when Y is present, it is selected from the group consisting of O, S, NR 8 , SO 2 , and CR 8 R 8′ ; R when present is one or more moieties independently selected from the group consisting of —(C 1 -C 6 )alkyl, and —(CR 8 R 8′ ) n —C(O)OH; G is present and is selected from the group consisting of —(CR 8 R 8′ ) n —C(O)OH, —(CR 8 R 8′ ) n —C(O)NR 8 R 9 , —(CR 8 R 8′ ) n —(C 3 -C 8 )cycloalkyl-C(O)NR 8 R 9 , —(CR 8 R 8′ ) n —(C 3 -C 8 )cycloalkyl-(CR 8 R 8′ ) n —C(O)OH, —(CR 8 R 8′ ) n —O—(CR 8 R 8′ ) n —(C 3 -C 8 )cycloalkyl-(CR 8 R 8′ ) n —C(O)OH, —(CR 8 R 8′ ) n —O—(CR 8 R 8′ ) n —C(O)OH, —(CR 8 R 8′ ) n —S—(CR 8 R 8′ ) n —C(O)OH, C(O)OH, —(CR 8 R 8′ ) n —NH—(CR 8 R 8′ ) n —C(O)OH, —(CR 8 R 8′ ) n —O—(CR 8 R 8′ ) n —CH 3 , —(CR 8 R 8′ ) n —S—(CR 8 R 8′ ) n —CH 3 , —(CR 8 R 8′ ) n —NH—(CR 8 R 8′ ) n —CH 3 , —(CR 8 R 8′ ) n —CH 3 , —(CR 8 R 8′ ) n -heteroaryl, —(CR 8 R 8′ ) n —P(O)OR 8 OR 8′ , and —(CR 8 R 8′ ) n —OH; each R 8 and R 8′ is independently selected from the group consisting of H, D, and (C 1 -C 6 )alkyl; or wherein R 8 and R 8′ together with the carbon to which each is attached form (C 3 -C 8 )cycloalkyl; each R 9 independently is SO 2 (C 1 -C 6 )alkyl or SO 2 (C 3 -C 8 )cycloalkyl; each n independently is 0-10; provided that when n is 0, any oxygen, nitrogen or sulfur atom of Y is not directly linked to any oxygen, nitrogen, sulfur or phosphorus atom of G; ----- represents a single or a double bond, provided that when E is present, ----- represents a single bond; R 2 is R 4 , R 4′ , R 5 , R 5′ , R 6 , R 6′ , R 7 , and R 7′ independently are selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl; and X is