Patent ID: 7384963

Claim:
A compound of formula (I): wherein R 1 is a phenyl group which may be optionally substituted up to three times, independently from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkoxy, trifluoromethyl, benzyloxy, hydroxy, cyano, hydroxyC 1-6 alkyl, —(CH 2 ) p CO(CH 2 ) q NR 5 R 6 , —(CH 2 ) p CO 2 R 7 , —(CH 2 ) p NR 5 COR 7 , —(CH 2 ) p OCOR 7 , —(CH 2 ) p OCONR 5 R 6 , —(CH 2 ) p NR 5 COOR 7 , —(CH 2 ) p COR 7 , —(CH 2 ) p SO 2 NR 5 R 6 , —(CH 2 ) p NR 5 SO 2 R 7 , —SO 2 R 7 , —(CH 2 ) p NR 5 R 6 , —O(CH 2 ) p NR 5 R 6 , —(CH 2 ) p NR 5 CO(CH 2 ) q NR 5 R 6 , —(CH 2 ) p CONR 5 SO 2 R 7 , —(CH 2 ) p SO 2 NR 5 COR 7 , a phenyl group optionally substituted by group A, and a phenyloxy optionally substituted by a group A; R 2 is selected from hydrogen, C 1-6 alkyl and —(CH 2 ) p —C 3-7 cycloalkyl; R 3 is the group R 4 is selected from hydrogen and C 1-4 alkyl; R 5 and R 6 are independently selected from hydrogen, C 1-6 alkyl, benzyl, —(CH 2 ) r OH, —(CH 2 ) r NR 8 R 9 and phenyl optionally substituted by up to three groups selected from C 1-6 alkyl halogen and C 1-6 alkoxy; or R 5 and R 6 together with the nitrogen atom to which they are bound, form a five or six-membered heterocyclic ring optionally containing one additional heteroatom selected from oxygen, sulphur and nitrogen, wherein the ring may be optionally substituted with C 1-4 alkyl; provided that when R 1 is substituted by —(CH 2 ) p NR 5 R 6 , then R 5 and R 6 are independently selected from hydrogen, C 1-6 alkyl, benzyl, —(CH 2 ) r OH, —(CH 2 ) r NR 8 R 9 and phenyl optionally substituted by up to three groups selected from C 1-6 alkyl halogen and C 1-6 alkoxy; R 7 is selected from hydrogen, C 1-6 alkyl, trifluoromethyl, phenyl optionally substituted by up to three groups selected from C 1-6 alkyl, C 1-6 alkoxy, halogen, —(CH 2 ) r OH, and —(CH 2 ) r NR 8 R 9 ; R 8 and R 9 are independently selected from hydrogen and C 1-4 alkyl; A is selected from halogen, —SO 2 NR x R Y , —NR 5 COC 1-6 alkyl and NR 5 SO 2 C 1-6 alkyl; R x and R y independently are hydrogen or C 1-4 alkyl or together with the nitrogen to which they are bound form a five or six-membered heterocyclic ring optionally containing one nitrogen atom, wherein the ring may be optionally substituted with methyl; U is selected from methyl and halogen; X and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4, and may be optionally substituted with up to two groups selected independently from C 1-6 alkyl; n is selected from 0, 1 and 2; p is selected from 0, 1 and 2; q is selected from 0, 1, 2 and 3; r is selected from 2 and 3; or a pharmaceutically acceptable salt or solvate thereof.