Patent ID: 8338173

Claim:
A method for cross-presentation of antigen to a CD8 + αβ T cell, comprising: obtaining an enriched γδ T cell population from a population of human peripheral blood mononuclear cells; stimulating an antigen-presenting function in the enriched γδ T cell population by exposing the enriched γδ T cell population to a non-peptide stimulus effective for inducing an antigen-presenting function, said non-peptide stimulus being specifically presented to the enriched γδ T cell population by a B cell population; obtaining a viable antigen-presenting γδ T cell population by exposing the stimulated γδ T cell population to a tumor- or microbial organism-derived antigen for uptake, processing, and presentation by the stimulated γδ T cell population; and specifically presenting the tumor- or microbial organism-derived antigen to a population of CD8 + αβ T cells contained in a human blood cell population via the viable antigen-presenting γδ T cell population.