Patent ID: 7439345

Claim:
A cyclohexylnucleooligoamide (CAN) oligomer, comprising monomeric subunits independently selected from a peptide nucleic acid (PNA) monomer and a monomeric subunit of formula (I): wherein: R 1 is NR 3 R 4 , wherein R 3 and R 4 independently of one another, identically or differently, are H or C n H 2n+1 , wherein n is equal to an integer from 1-12; R 2 is C m H 2m —C(X)—Y where X is ═O and Y is OR 3 and wherein m is an integer from 1-4; R 5 and R 6 each independently is H or C n H 2n+1 ; and nucleobase is selected from the group consisting of 1-thyminyl, 1-uracilyl, 9-adeninyl, 1-cytosinyl, 9-guaninyl, 1-isocytosinyl, 9-isoguaninyl, 9-xanthinyl, and 9-hypoxanthinyl, wherein each nucleobase is optionally provided with one or more protective groups; wherein: at least one monomeric subunit of the oligomer is a monomeric subunit of formula (I); the monomeric subunits of the oligomer are linked by amide bonds; and the monomeric subunit(s) of formula (I) in the oligomer are linked 2′→4′.