Patent ID: 8278044

Claim:
A method for the identification of genotoxic compounds, the method comprising: exposing a eukaryotic cell to a potentially genotoxic compound in a culture medium; taking a sample from the cell and/or the culture medium at at least one predetermined time point; analyzing the sample for increased or decreased expression levels of POLR2D, RAD51, XRCC4, SMUG1, POLR2A, DDB2, MBD4, MAD2L2, ERCC1, ERCC3, REV3L and MGMT as compared to a control cell that is not exposed to the potentially genotoxic compound; and identifying the compound as genotoxic based upon the analysis of the expression levels of POLR2D, RAD51, XRCC4, SMUG1, POLR2A, DDB2, MBD4, MAD2L2, ERCC1, ERCC3, REV3L and MGMT.