Patent ID: 6989138

Claim:
A composition comprising, (1) a radiopharmaceutical precursor comprising a target moiety selected from the group consisting of an antibody, a Fab antibody fragment, a F(ab)′ 2 antibody fragment, an epitope binding complementarity determining region derived from an antibody, a peptide, a growth factor, a receptor binding fragment of a growth factor, a hormone, a steroid, a receptor binding nucleic acid, a receptor binding monosaccharide, a receptor binding disaccharide, a receptor binding oligosaccharide, a receptor-binding lipid, a receptor binding benzodiazepine and a receptor binding antibiotic; and (2) a stabilizing amount of a mixture of a hydrophilic thioether of the formula: R—S—CH 2 C(R 1 R 2 R 3 ) wherein: R is C 1 to C 4 alkyl or a C 1 to C 4 alkyl containing at least one hydrophilic group selected from —COOH, —NH 2 , —NHR 4 , —NR 42 , —OH, —SO 2 R 4 , —SOR 4 , —SO 3 H, —CONH 2 , —CONHR 4 , —CONR 4 2 , —COOR 4 , —OR 4 , —SR 4 , —NO 2 , —SO 2 NH 2 , —SO 2 NHR 4 , and —SO 2 NR 4 2 ; with the proviso that, when R is methyl, the hydrophilic group is not NH 2 , NHR 4 , NR 4 2 or OH; R 1 , R 2 , and R 3 are each independently selected from the group consisting of H, —COOH, —NH 2 , —NHR 4 , —NR 4 2 , —OH, —SO 2 R 4 , —SOR 4 , —SO 3 H, CONH 2 , —CONHR 4 , —CONR 4 2 , —COOR 4 , —OR 4 , —SR 4 , —NO 2 , —SO 2 NH 2 , and —SO 2 NHR 4 , —SO 2 NR 4 2 , C 1 to C 4 alkyl, and a C 1 to C 3 alkyl containing at least one hydrophilic group selected from the group consisting of —COOH, —NH 2 , —NHR 4 , —NR 4 2 , —OH, —SO 2 ; —SO 3 R 4 , —SO 3 H, —CONH 2 , —CONHR 4 , —CONR 4 2 , —COOR 4 , OR 4 , SR 4 , —NO 2 , —SO 2 NH 2 , and —SO 2 NHR 4 , —SO 2 NR 4 2 with the proviso that only one of R 1 , R 2 , and R 3 is NH 2 , NHR 4 , NR 4 2 or OH; and R 4 is selected from the group consisting of C 1 to C 3 alkyl; and with the further proviso that the hydrophilic thioether comprise at least one of said hydrophilic groups and (3) a 6-hydroxy-chroman derivative of the formula wherein one of Y and Z is selected from the group consisting of O, S, C═O, and (CHR 3 ) n , where n is an integer from 0 to 3, and the other of Y and Z is selected from the group consisting of C═O and (CHR 3 ) n where n is an integer from 0-3; each R 3 group is independently selected from the group consisting of H, alkyl, halogen, —OR 4 , —SO 3 H, —SO 3 R 4 , —S(O) m R 4 , —COOR 4 , —NO 2 , μCONH m (R 4 ) 2-m , —NH m (R 4 ) 2-m , —COR 4 ,—CH 2 OR 4 , —COR 5 , —SO 2 NH m (R 4 ) 2-m , —R 5 , and —CH 2 R 5 , where m is an integer from 0 to 2; R 4 is H or C 1 to C 3 alkyl; and R 5 is selected from the group consisting of a monosaccharide, disaccharide, and a hydrophilic peptide sequence of up to 5 amino acids comprising at least one hydrophilic amino acid residue.