Patent ID: 8758286

Claim:
A device for removing at least one adsorbate selected from cytokines, pathogens and toxins from blood which comprises a container, said container comprising a solid substrate of high surface area having at least one polysaccharide adsorbent on the surface thereof with a binding affinity for the adsorbate, wherein said substrate is sufficiently solid such that the adsorbate does not pass through pores in said substrate, and wherein the size of interstitial channel spaces within said substrate is large enough to permit the transport of blood cells, and the amount of interstitial surface area within said substrate is such that when flowing blood is in contact with said substrate through said device, said cytokine, pathogen or toxin binds to binding sites on said at least one polysaccharide adsorbent, becoming separated from said blood and the transport of said adsorbates from blood to adsorbent sites on said substrate is primarily by convection transport, such that adsorbate binding does not require the Brownian diffusion of adsorbates into pores within said substrate.