Patent ID: 7049309

Claim:
A compound of formula (I) wherein: R and R 1 are independently hydrogen or methyl; R 2 , R 3 , and R 4 are independently hydrogen, halogen, cyano, nitro, or trifluoromethyl, provided R 2 , R 3 , and R 4 are not all hydrogen; R 5 is bromo, chloro, or nitro; R 6 and R 7 are independently hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 3-7 cycloalkyl, —CH 2 C 3-7 cycloalkyl, —(CH 2 ) 1-3 OH, —(CH 2 ) 2-3 NR 8 R 9 , —(CH 2 ) 1-3 CN, or —(CH 2 ) 1-3 Ar, where Ar is selected from the group consisting of phenyl, naphthyl, furanyl, thienyl, and pyridyl, and Ar is unsubstituted or substituted with 1–2 methoxy substituents; or NR 6 R 7 taken together form or NR 6 R 7 taken together is selected from the group consisting of R 8 and R 9 are independently hydrogen or C 1-6 alkyl; R 10 is a bond, O, S, NR 11 , or CHR 12 ; R 11 is hydrogen, C 1-6 alkyl, CHO, C(O)Me, —(CH 2 ) 2-3 OH, —CH 2 CH 2 OCH 2 CH 2 OH, —(CH 2 ) 2-3 NR 8 R 9 , —(CH 2 ) 2-3 CONR 8 R 9 , —C(O)furanyl, —CH 2 CH═CHPh, pyridinyl, pyrazinyl, or anisolyl; R 12 is hydrogen, hydroxy, C 1-6 alkyl, —CH 2 Ph, —C(O)OR 8 , —CONR 8 R 9 , —(CH 2 ) 1-3 NR 8 R 9 , or 1-piperidinyl; and p is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.