Patent ID: 7980276

Claim:
A method comprising: filling a device defining a chamber, a thermoplastic portion in fluid communication with the chamber, and a penetrable region of the thermoplastic portion, wherein the thermoplastic portion includes a first polymeric material in a first amount by weight including a styrene block copolymer and defining a first elongation, and a second polymeric material in a second amount by weight that is less then the first amount, including at least one of an ethylene alpha-olefin, a polyolefin, and an olefin, and defining a second elongation that is less than the first elongation, the filling step comprising the following steps: penetrating the penetratable region of the thermoplastic portion with a non-coring, conically-pointed tip of an injection member defining at least one flow aperture located adjacent to the tip and connectable in fluid communication with a source of substance such that the flow aperture of the injection member is in fluid communication with the chamber of the device, and substantially preventing the formation of particles released into the chamber from the thermoplastic portion during penetration by the injection member; reducing friction forces at the interface of the injection member and penetrable region with a lubricant; introducing the substance through the injection member and into the chamber of the device, withdrawing the injection member from the penetrable region, and substantially preventing the formation of particles released into the chamber from the thermoplastic portion during withdrawal of the injection member; and hermetically sealing an aperture formed in the penetrable region of the thermoplastic portion.