Patent ID: 7745457

Claim:
A compound of the structure: wherein: R 1 and R 2 are, independently selected from the group consisting of, OH, oxo, O(C 1 to C 6 alkyl), O(substituted C 1 to C 6 alkyl), O(acyl), O(aryl), O(substituted aryl), O(heterocyclyl), or O(substituted heterocyclyl); R 3 , R 5 , and R 6 are independently are selected from the group consisting of OH, oxo, O(C 1 to C 6 alkyl), O(substituted C 1 to C 6 alkyl), O(acyl), O(aryl), O(substituted aryl), O(heterocyclyl), and O(substituted heterocyclyl); R 4 is selected from the group consisting of oxo, O(C 1 to C 6 alkyl), O(substituted C 1 to C 6 alkyl), O(acyl), O(aryl), O(substituted aryl), O(heterocyclyl), and O(substituted heterocyclyl); or R 3 and R 4 and/or R 5 and R 6 are joined together to form a structure: or, R 4 and R 5 are joined to form a structure: wherein X and Y are independently selected from the group consisting of H, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl; wherein the alkyl is substituted with one to three substituents each independently selected from halogen, CN, OH, NO 2 , amino, aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, alkylcarbonyl, alkylcarboxy, alkylamino, and arylthio; wherein aryl is a carbocyclic aromatic system having a single ring or multiple aromatic rings fused or linked together forming a conjugated aromatic system and wherein the aryl can be optionally substituted with one to four substituents each independently selected from halogen, CN, OH NO 2 , amino, aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, alkylcarbonyl, alkylcarboxy, alkylamino, and arylthio; wherein heterocyclyl is a 4- to 7-membered monocyclic or stable multicyclic heterocyclyl ring, which is saturated, partially saturated, or unsaturated, including carbon atoms and from one to four heteroatoms selected from N, O and S; and may be optionally substituted with one to four substituents each independently selected from halogen, CN, OH NO 2 , amino, aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, alkylcarbonyl, alkylcarboxy, alkylamino, and arylthio; wherein the acyl is an RCO group, where R is a C 1 to C 6 alkyl or substituted C 1 to C 6 alkyl as defined above and the point of attachment is on the carbon atom R 7 is CH 2 , CHOH, or C═O; and n is 1 or 2; or a pharmaceutically acceptable salt thereof.