Patent ID: 8759324

Claim:
A method of treating a subject in need thereof with cyclophosphamide, the improvement comprising: concurrently administering said subject a metalloporphyrin in an amount effective to enhance the efficacy of said cyclophosphamide in said subject; wherein said metalloporphyrin comprises a transition metal(III)-substituted macrocyclic ligand complex containing a coordinated metal selected from the group consisting of iron, manganese, cobalt, nickel, ruthenium, and copper; and a pharmaceutically acceptable carrier; said subject having cancer, thrombotic thrombocytopenic purpura, Sjogren's syndrome, Reiter's syndrome, progressive systemic sclerosis, pemphigus, pemphigoid, necrotizing vasculitis, myasthenia gravis, multiple sclerosis, lupus erythematosus, sarcoidosis, granulomatosis, vasculitis, glomerulonephritis, chronic active hepatitis, ankylosing spondylitis, or Addison's disease.