Patent ID: 7998492

Claim:
A method of controlling viral replication and viral spread in a human subject having an HCV infection that was not successfully treated using a previous non-CpG therapy comprising administering to a subject in need thereof an antiviral agent and a C class CpG immunostimulatory nucleic acid having a semi-soft backbone and comprising a sequence of 5′ X 1 DCGHX 2 3′ wherein C is unmethylated, X 1 and X 2 are any nucleic acid sequence 0-10 nucleotides long, D is a nucleotide other than C, and H is a nucleotide other than G, and a sequence of 5′ CGG 3′, wherein the nucleic acid is 8 to 100 nucleotides in length, in an amount effective to control viral replication and viral spread of HCV.