Patent ID: 8242175

Claim:
A compound of formula (I) wherein: Q is a bond, CH 2 , CH—NR 3 R 4 , NR 5 or oxygen; X is CH or nitrogen; Y is a bond, CH 2 , oxygen or NR 6 ; Z is CH or nitrogen; R 1 , R 2 are, independently, hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl: R 3 , R 4 are, independently, hydrogen, C 1 -C 6 alkyl, phenyl or benzyl; R 5 is hydrogen, C 1 -C 6 alkyl, (CO)R 7 , SO 2 —C 1 -C 6 alkyl, phenyl or benzyl; R 6 is hydrogen, C 1 -C 6 alkyl or benzyl; R 7 is hydrogen, C 1 -C 6 alkyl, phenyl, benzyl, OR 8 or NR 9 R 10 ; R 8 is C 1 -C 6 alkyl; R 9 is hydrogen, C 1 -C 6 alkyl, phenyl or benzyl; R 10 is hydrogen, C 1 -C 6 alkyl or benzyl; R 11 , R 12 are, independently, hydrogen or C 1 -C 6 alkyl; and the pharmaceutically acceptable salts thereof; with the proviso that when X is nitrogen, Y cannot be oxygen or NR 6 ; and with the exclusion of the following compounds: (E)-N-Hydroxy-3-(4-{(E)-3-[4-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide; (E)-N-Hydroxy-3-{4-[(E)-3-(4-morpholin-4-yl-phenyl)-3-oxo-propenyl]-phenyl}-acrylamide; (E)-3-{3-Fluoro-4-[(E)-3-(4-morpholin-4-yl-phenyl)-3-oxo-propenyl]-phenyl}-N-hydroxy-acrylamide.