Patent ID: 7683076

Claim:
A urea derivative of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: wherein m represents 0, 1, 2, or 3; p represents 0, 1, 2, or 3; —X— represents a bond, —O— or —N(R 10 )— (wherein R 10 is hydrogen or C 1-6 alkyl); with the proviso that when m is 0, —X— represents a bond, R A and R B represent hydrogen, or R A and R B together form a carbonyl-group with the carbon-atom to which they are connected, R 1 represents aryl or heteroaryl wherein said aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of halogen, nitro, hydroxy, carboxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 3-8 cycloalkylamino, C 1-6 alkoxycarbonyl, phenyl (which phenyl is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 3-8 cycloalkylamino, or C 1-6 alkoxycarbonyl), benzyl (in which phenyl moiety is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 3-8 cycloalkylamino, or C 1-6 alkoxycarbonyl), sulfonamide, C 1-6 alkanoyl, C 1-6 alkanoylamino, carbamoyl, C 1-6 alkylcarbamoyl, cyano, C 1-6 alkyl (which alkyl is optionally substituted by cyano, nitro, hydroxy, carboxy, amino, C 1-6 alkoxycarbonyl or mono-, di-, or tri-halogen), C 1-6 alkoxy (which alkoxy is optionally substituted by mono-, di-, or tri-halogen), phenoxy (in which phenyl moiety is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 3-8 cycloalkylamino, or C 1-6 alkoxycarbonyl or C 1-6 alkyl), C 1-6 alkylthio (which alkylthio is optionally substituted by mono-, di-, or tri-halogen), C 3-8 cycloalkyl, and heterocycle; and R 2 represents C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl, hydrogen, hydroxy, aryl, heteroaryl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, arylsulfonyl, or heteroarylsulfonyl, wherein said alkyl, alkenyl or alkynyl are optionally substituted by mono-, di-, or tri-halogen, hydroxy, carboxyl, nitro, cyano, C 1-6 alkoxy, C 1-6 alkoxycarbonyl, C 3-8 cycloalkyl, amino, N-(C 1-6 alkyl)amino, N,N-di(C 1-6 alkyl)amino, N-(aryl)amino, N-(heteroaryl)amino, carbamoyl, N-(C 1-6 alkyl)aminocarbonyl, or N,N,-di(C 1-6 alkyl)aminocarbonyl, and said cycloalkyl, aryl, heteroaryl, aryl moiety of said arylsulfonyl, or heteroaryl moiety of said heteroarylsulfonyl are optionally substituted by mono-, di-, or tri-halogen, hydroxy, carboxyl, cyano, nitro, (C 1-6 alkoxy)carbonyl, C 3-8 cycloalkyl, amino, N-(C 1-6 alkyl)amino, N,N-di(C 1-6 alkyl)amino, N-(aryl)amino, N-(heteroaryl)amino, carbamoyl, N-(C 1-6 alkyl)aminocarbonyl, N,N-di(C 1-6 alkyl)aminocarbonyl, C 1-6 alkyl optionally substituted by mono-, di-, or tri-halogen, or C 1-6 alkoxy optionally substituted by mono-, di-, or tri-halogen.