Patent ID: 7671087

Claim:
A method of treating asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, allergy, arthritis, Crohn's disease, malignant gliomas, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, or stroke, comprising the step of: administering to a patient a therapeutically effective amount of a compound of formula A or B, wherein Z represents alkyl, cycloalkyl, alkenyl, aralkyl, heteroaralkyl, hydroxyalkyl, alkoxyalkyl, heterocyclyl, —(CH 2 ) n —R 80 , or a covalent tether to a solid support; Ar represents aryl or heteroaryl; X represents aryl, heteroaryl, (aryl)alkenyl, (heteroaryl)alkenyl, or —(CH 2 ) n —R 80 ; R A is absent or present 1, 2, 3, 4, or 5 times; R B is absent or present 1, 2, 3, or 4 times; R represents independently for each occurrence alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, halogen, heteroaralkyl, hydroxyl, alkoxyl, amino, alkylamino, carboxylate, carboxamide, nitroso, nitro, sulfhydryl, alkylthio, thioalkyl, silyl, alkylsulfonyl, arylsulfonyl, formyl, acyl, acyloxy, acylamino, alkyloxycarbonyl, alkenyloxycarbonyl, aryloxycarbonyl, or —(CH 2 ) n —R 80 ; R′ represents independently for each occurrence H, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, or —(CH 2 ) n —R 80 ; R 80 represents independently for each occurrence cycloalkyl, alkenyl, aryl, heteroaryl, or heterocyclyl; n is an integer selected independently for each occurrence from the range 0 to 8 inclusive; the absolute stereochemistry at a stereocenter in a compound represented by A is R, S, or a mixture thereof; the absolute stereochemistry at a stereocenter in a compound represented by B is R, S, or a mixture thereof; the configuration of an alkenyl moiety in a compound represented by A is E, Z, or a mixture thereof; and the configuration of an alkenyl moiety in a compound represented by B is E, Z, or a mixture thereof.