Patent ID: 7820803

Claim:
A probe having any of the following general formulae: wherein: R=aryl or alkyl group; R=C m H 2m+1 , where m=8-20; R 3 =P(O)(OM) 2 ; R 4 =H; R 5 =H (PI(3)P); R 3 =H; R 4 =P(O)(OM) 2 , R 5 =H (PI(4)P); R 3 =H; R 4 =H; R 5 =P(O)(OM) 2 (PI(5)P); R 3 =P(O)(OM) 2 ; R 4 =P(O)(OM) 2 ; R 5 =H (PI(3,4)P 2 ); R 3 =P(O)(OM) 2 ; R 4 =H; R 5 =P(O)(OM) 2 (PI(3,5)P 2 ); R 3 =H; R 4 =P(O)(OM) 2 ; R 5 =P(O)(OM) 2 (PI(4,5)P 2 ); or R 3 =P(O)(OM) 2 ; R 4 =P(O)(OM) 2 ; R 5 =P(O)(OM) 2 (PI(3,4,5)P 3 ); M=any cation including Na + , NH4 + ; *Denotes a stereogenic centre; Linker=(CH 2 ) n with n=8-20; X=O, S, or NH; FG=Carbonyl from a carboxylate, thiolo(ester), or an amide; unsaturations are allowed, including in an arachidonyl side chain; =solid support with attachment to functional group; wherein: R=aryl or alkyl group; R=C m H 2m+1 , where m=8-20; R 3 =P(O)(OM) 2 ; R 4 =H; R 5 =H (PI(3)P); R 3 =H; R 4 =P(O)(OM) 2 ; R 5 =H (PI(4)P); R 3 =H; R 4 =H; R 5 =P(O)(OM) 2 (PI(5)P); R 3 =P(O)(OM) 2 ; R 4 =P(O)(OM) 2 ; R 5 =H (PI(3,4)P 2 ); R 3 =P(O)(OM) 2 ; R 4 =H; R 5 =P(O)(OM) 2 (PI(3,5)P 2 ); R 3 =H; R 4 =P(O)(OM) 2 , R 5 =P(O)(OM) 2 (PI(4,5)P 2 ); or R 3 =P(O)(OM) 2 ; R 4 =P(O)(OM) 2 , R 5 =P(O)(OM) 2 (PI(3,4,5)P 3 ); M=any cation including Na + and NH4 + ; *Denotes a stereogenic centre; X=O, S, or NH; FG A=Carbonyl from a carboxylate, thiolo(ester), or an amide; Linker A=(CH 2 ) n with n=8-20; Linker B=aryl, heteroaryl, alkyl with possible heteroatoms and/or saturations; these could be any atoms, including C, N, O, S, or methylene groups linked via amide and ester bonds; FG B=Amide, thiolo(ester), or ester; unsaturations are allowed, including in an arachidonyl side chain; =solid support with attachment to functional group.