Patent ID: 7671051

Claim:
A method for the treatment of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, without causing hypoglycemia, said method comprising administering to a mammal in need of such treatment an effective amount of a compound of formula (I) wherein T is an aryl ring or heteroaryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, aryl, heteroaryl, a heterocyclic ring, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, C 1-6 -alkylsulfonyl, carboxy, cyano, nitro, halogen, amine which is optionally mono- or di-substituted, amide which is optionally mono- or di-substituted, aryloxy, arylsulfonyl, arylamino, wherein aryl, heteroaryl and aryloxy residues and heterocyclic rings are further optionally substituted in one or more positions independently of each other by C 1-6 -acyl, C 1-6 alkylthio, cyano, nitro, hydrogen, halogen, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, amide which is optionally mono- or di-substituted, (benzoylamino)methyl, carboxy, or 2-thienylmethylamino or ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl); R 1 is hydrogen or C 1-6 -alkyl; X is CH 2 or CO; Y is CO; B is hydrogen, C 1-6 -alkyl or dimethylaminomethyl; R 2 is selected from C 1-6 -alkyl, azido, arylthio, heteroarylthio, halogen, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl, 3-oxo-4-morpholinolinylmethylene, C 1-6 -alkoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl; NR 3 R 4 , wherein R 3 and R 4 are each independently selected from hydrogen, C 1-6 -alkyl, optionally halogenated C 1-6 -alkylsulfonyl, C 1-6 -alkoxy, 2-methoxyethyl, 2-hydroxyethyl, 1-methylimidazolylsulfonyl, C 1-6 -acyl, cyclohexylmethyl, cyclopropanecarbonyl, aryl, optionally halogenated arylsulfonyl, furylcarbonyl, tetrahydro-2-furanylmethyl, N-carbethoxypiperidyl or C 1-6 -alkyl substituted with one or more aryl, heterocyclic or heteroaryl, or NR 3 R 4 represent together heterocyclic systems which are imidazole, piperidine, pyrrolidine, piperazine, morpholine, oxazepine, oxazole, thiomorpholine, 1,1-dioxidothiomorpholine, 2-(3,4-dihydro-2 (1H)isoquinolinyl), or (1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl, which heterocyclic systems are optionally substituted by C 1-6 -alkyl, C 1-6 -acyl, hydroxy, oxo, t-butoxycarbonyl; OCONR 3 R 4 , wherein R 3 and R 4 are each independently selected from hydrogen, C 1-6 -alkyl or form together with the N-atom to which they are attached morpholinyl; R 5 O, wherein R 5 is hydrogen, optionally halogenated C 1-6 -alkyl, aryl, heteroaryl, C 1-6 -acyl, C 1-6 -alkylsulfonyl, arylcarbonyl, heteroarylcarbonyl, 2-carbomethoxyphenyl; or a salt or hydrate thereof.