Patent ID: 7037530

Claim:
A dry granulation process for manufacturing a pharmaceutical composition having uniform drug distribution and potency, the process comprising in the following order the steps of: (1) blending silicon dioxide and at least one pharmaceutically acceptable excipient, carrier or diluent in a high shear granulator for an appropriate amount of time to produce a blended mixture; (2) adding an active ingredient to the granulator and blending for an additional period of time to form an active blend; (3) transferring the active blend from the granulator to a blender; (4) optionally, adding one or more additional pharmaceutically acceptable excipients, carriers or diluents to the active blend; and (5) blending for a suitable period of time to form a pharmaceutical composition having uniform distribution of the active ingredient and uniform potency, wherein said active ingredient is a compound of Formula (I) where E and B are independently selected from CH and N; R 1 is hydrogen, hydroxy, fluoro or chloro; and G is or a pharmaceutically acceptable salt, hydrate or solvate of said compound.