Patent ID: 8871908

Claim:
An isolated antibody, or an antigen binding fragment thereof, which specifically binds to trophoblast cell-surface antigen-2 (Trop-2), wherein the antibody comprises (a) a heavy chain variable (VH) region comprising (i) a VH complementary determining region one (CDR1) comprising the sequence SYGVH (SEQ ID NO: 30), GGSISSY (SEQ ID NO: 36), or GGSISSYGVH (SEQ ID NO: 37); (ii) a VH CDR2 comprising the sequence VIWTX 1 GX 2 TDYNSALMX 3 , wherein X 1 is G or S; X 2 is S or V; X 3 is S or G (SEQ ID NO: 49), or WTX 1 GX 2 , wherein X 1 is G or S, X 2 is S or V (SEQ ID NO: 50); and iii) a VH CDR3 comprising the sequence DGDYDRYTMDY (SEQ ID NO: 35); and (b) a light chain variable region (VL) comprising (i) a VL CDR1 comprising the sequence RASKSVSTSX 1 YSYMH, wherein X 1 is G, L, or N (SEQ ID NO: 63); (ii) a VL CDR2 comprising the sequence LASNLES (SEQ ID NO: 55); and (iii) a VL CDR3 comprising the sequence QHSRELPYT (SEQ ID NO: 56).