Patent ID: 8668932

Claim:
A controlled release composition consisting essentially of: (1) an immediate release pellet consisting essentially of: (a) 30-80% of venlafaxine, its o-desmethylvenlafaxine active metabolite, or pharmaceutically acceptable salts thereof; (b) 20-70% of an inert sugar pellet; and (c) 1-20% of a binder; and (2) an extended release pellet consisting essentially of: (i) a core consisting essentially of: (a) 30-80% of venlafaxine, its o-desmethylvenlafaxine active metabolite, or pharmaceutically acceptable salts thereof; (b) 20-70% of an inert sugar pellet; and (c) 1-20% of a binder; (ii) a coating surrounding the core consisting essentially of: (a) 40-99% of a water insoluble polymer; (b) 0-30% of a surfactant; (c) 0-15% of an antisticking agent; and (d) 0-30% of a plasticizer; wherein a single peak plasma concentration of the venlafaxine or o-desmethylvenlafaxine active metabolite is obtained in less than four hours after administration of the controlled release composition when administered in a single dose under fasting conditions, and the extended release pellets comprises about 40-80% of the controlled release composition.