Patent ID: 8309567

Claim:
A compound of formula I: wherein: Y is C═O; R 1 is optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, aminocarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy, cyano, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, formyl, optionally substituted heterocyclyl, optionally substituted alkylthio, NO or NR 13 R 14 where R 13 and R 14 are independently hydrogen, COR 15 , optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl or R 13 and R 14 together with the N atom to which they are attached form a group —N═C(R 16 )—NR 17 R 18 ; R 15 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted aryloxy optionally substituted heteroaryl, optionally substituted heteroaryloxy or NR 19 R 20 ; R 16 , R 17 and R 18 are each independently H or lower alkyl; R 19 and R 20 are each independently optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R 2 and R 3 are each independently hydrogen, halogen, cyano, optionally substituted alkyl or optionally substituted alkoxy; each R 4 is independently halogen, cyano, optionally substituted C 1-8 alkyl, optionally substituted C 3-7 cycloalkyl, optionally substituted alkoxy; n is 0, 1, 2, 3 or 4; R 8 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl or optionally substituted alkenylcarbonyl; A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 and B 4 are each independently hydrogen, halogen, cyano, optionally substituted C 1-8 alkyl, optionally substituted C 3-7 cycloalkyl or optionally substituted alkoxy; or salts or N-oxides thereof provided that when B 1 , B 2 , B 3 and B 4 are all H, either both A 1 and A 2 are different from H or both A 3 and A 4 are different from H.