Patent ID: 8729251

Claim:
A method for synthesizing an oligonucleotide comprising attaching a linker to a substrate, wherein the linker has a first linker protecting group protecting a first linker reactive group, removing the first linker protecting group and attaching a first nucleic acid monomer to the first linker reactive group to provide an attached first nucleic acid monomer, wherein the first nucleic acid monomer includes a first reactive group and a first protecting group protecting a first reactive site, removing the first protecting group and attaching a second nucleic acid monomer to the first reactive site of the first nucleic acid monomer to provide an attached second nucleic acid monomer, wherein the second nucleic acid monomer includes a second reactive group and a second protecting group protecting a second reactive site, removing the second protecting group and attaching a third nucleic acid monomer to the second reactive site of the second nucleic acid monomer to provide an attached third nucleic acid monomer, wherein the third nucleic acid monomer includes a third reactive group and a third protecting group protecting a third reactive site, repeating steps of removing a protecting group and attaching a nucleic acid monomer to a reactive site until a desired oligonucleotide is complete, wherein at least one of the first linker protecting group, first protecting group, second protecting group, third protecting group or protecting group is a compound represented by the following structural formula: wherein: X is a nucleic acid monomer; R 1 and R 2 form a fused aryl ring, R 3 is H; and Ar is aryl.