Patent ID: 8389521

Claim:
A compound according to the general Formula I: wherein R 1 is selected from the group consisting of —NR 5 R 6 , —R 8 , —C 1-4 alkyl-OH, and —C 2-4 -alkylene-O—C 1-4 alkyl; wherein R 5 and R 6 independently of each other are selected from the group consisting of hydrogen, C 1-4 alkyl, C 2-4 alkenyl, hydroxy-C 1-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-4 alkyl or C 4-7 heterocycloalkyl-C 0-4 alkylene, C 4-7 aryl-C 0-4 alkylene, and C 4-7 heteroaryl-C 0-4 alkylene, or wherein R 5 and R 6 together with the N-atom to which they are bound also form a 5- to 8-membered heterocycloalkyl or a 5- to 6 membered heteroaryl, wherein said cycloalkyl, heterocycloalkyl, aryl, heteroaryl or alkyl is further optionally substituted by up to 2 radicals selected from the group consisting of halo, hydroxy, C 1-4 alkyl, hydroxy-C 1-4 alkyl, C 1-4 alkyl-O—C 1-4 alkylene, C 1-4 alkyl-O—, and —NR 5 R 6 ; R 8 is C 1-4 alkyl, C 2-4 alkenyl, hydroxy-C 2-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-4 alkyl or C 4-7 heterocycloalkyl-C 0-4 alkyl; wherein said cycloalkyl, heterocycloalkyl or alkyl is further optionally substituted by up to 2 radicals selected from the group consisting of halo, hydroxy, C 1-4 alkyl, hydroxy-C 1-4 alkyl, C 1-4 alkyl-O—C 1-4 alkylene, C 1-4 alkyl-O, and —NR 5 R 6 ; R 2 can be 0 to 2 independent halo substituents; R 3 can be 1 to 3 substituents independently selected from the group consisting of hydrogen, halo, hydroxy, C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkyl-cycloalkyl, C 1-4 alkyl-heterocycloalkyl, —O-heterocycloalkyl, C 1-4 alkoxy, C 1-4 alkenyloxy, —OCF 3 , C 2-4 alkanoyl, C 1-4 -alkylsulfonyl, mono- and di-(C 1 -C 4 alkyl)sulfonamido, aminocarbonyl, mono- and di-(C 1 -C 4 alkyl)aminocarbonyl, alkoxy, heteroaryl-C 1-4 alkoxy, heterocycloalkyl-C 1-4 alkoxy, heterocycloalkyl-C 1-4 alkyl, heteroaryl-C 1-4 -alkyl, C 1-4 alkyloxymethyl, hydroxy-C 1-4 alkyloxymethyl, cyano, —COOH, and C 1 -C 4 alkoxycarbonyl, wherein the above mentioned substituents can be further substituted by radicals selected from the group consisting of C 1-4 -alkyl, hydroxyl-C 0-4 -alkyl, aminocarbonyl, halo, and NR 5 R 6 ; R 4 is hydrogen, C 1-4 alkyl or —NR′R″, wherein R′ and R″ each are independently selected from hydrogen, and C 1-4 alkyl; and N oxides of such compounds.