Patent ID: 8644914

Claim:
A non-invasive method of measurement of drug induced changes in cardiac ion channel and electrical function, said method comprising: obtaining a baseline electrocardiogram recorded on a body surface of a person to whom a drug under test has not been administered; using a mathematical transformation or convolution of said baseline electrocardiogram and of a typical epicardial electrocardiogram, in order to obtain a filter function representative of biophysical electrical transmission characteristics between epicardial tissue and body surface, said filter function effectively modifying the typical epicardial electrocardiogram to become a body surface electrocardiogram; obtaining a second electrocardiogram recorded on the body surface of said person to whom the drug under test has been administered; applying said filter function on a mathematical transformation or convolution of said second electrocardiogram in order to obtain a third electrocardiogram representative of a myocardial wedge simulated epicardial electrocardiogram of a person to whom the drug under test has been administered; and using said third electrocardiogram to measure any drug induced changes in cardiac ionic channel and electrical function as a result of said drug under test based on measurements of a shape of the third electrocardiogram.