Patent ID: 7067532

Claim:
A compound of Formula (Ia), or a pharmaceutically acceptable salt thereof wherein: n is 0 or 1; Y is selected from —NH— or —NR 7 — where R 7 is alkyl of 1–6 carbon atoms; R 5 is cyano, fluoro, chloro or bromo; R 6 is a group —R 8 —X—R 9 where R 8 is a phenyl ring; wherein the phenyl ring may be optionally further substituted with one or more groups selected from halogen, alkyl of 1–6 carbon atoms, alkenyl of 2–6 carbon atoms, alkynyl of 2–6 carbon atoms, azido, hydroxyalkyl of 1–6 carbon atoms, halomethyl, alkoxymethyl of 2–7 carbon atoms, alkanoyloxymethyl of 2–7 carbon atoms, alkoxy of 1–6 carbon atoms, alkylthio of 1–6 carbon atoms, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy of 2–7 carbon atoms, carboalkyl of 2–7 carbon atoms, phenoxy and phenyl; and where X is selected from —NH—, —S—, CH 2 or —NR 7′ — where R 7′ is alkyl of 1–6 carbon atoms, and R 9 is a group (CH 2 ) m R 10 where m is 0 or an integer of from 1–3 and R 10 is an optionally substituted aryl or optionally substituted cycloalkyl ring of up to 10 carbon atoms, or R 10 is a optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; or where X is —O—, and R 9 is a group (CH 2 ) m R 10 where m is 0 or an integer of from 1–3 and R 10 is aryl, a cycloalkyl ring of up to 10 carbon atoms, a heterocyclic ring or an N-oxide of any nitrogen containing ring wherein each R 10 group bears at least one substituent group; R 1 , R 2 , R 4 are independently selected from hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, —NR 11 R 12 — (wherein R 11 and R 12 , which may be the same or different each represents hydrogen, or C 1-3 alkyl), or a group R 13 —X 1 —(CH 2 ) x wherein x is 0 or an integer of from 1 to 3, X 1 represents —O—, —S—, —SO—, —SO 2 —, or —NR 18 —(wherein R 18 is hydrogen, C 1-3 alkyl or C 1-3 alkoxyC 2-3 alkyl)), and R 13 is an optionally substituted hydrocarbyl; and R 3 is a group of formula —X 1 —R x′ —X 1a (C 3-6 cycloalkyl) where X 1 is as defined above, R 1a is as defined for X 1 above and R x′ is an alkylene.