Patent ID: 8318145

Claim:
A multi-arm polymer prodrug having the structure: wherein R is an organic radical possessing from 3 to 25 carbon atoms, Q is a linker, wherein R, when taken together with Q to form R(-Q-) q , is a residue of a polyol or a polythiol after removal of “q” hydroxyl or thiol protons, respectively, to form a point of attachment for POLY 1 , POLY 1 is a water-soluble polymer selected from the group consisting of poly(alkylene glycol), poly(olefinic alcohol), poly(vinylpyrrolidone), poly(hydroxylalkyl-methacrylamide), poly(hydroxyalkyl-methacrylate), poly(a-hydroxy acid), poly(acrylic acid), poly(vinyl alcohol), polyphosphazene, polyoxazoline, poly(N-acryloylmorpholine), and copolymers or terpolymers thereof, D is a small molecule anticancer drug, with the proviso that the drug is not paclitaxel or docetaxel, and q has a value from 3 to 10.