Patent ID: 8921559

Claim:
A compound of Formula (I) wherein: R 1 is 2,3-dihydroindol-3-yl, indol-3-yl, pyridyl, pyrimidyl, pyridazyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, or pyrrolyl; wherein said pyridyl, pyrimidyl, pyridazyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, or pyrrolyl is optionally substituted with OCH 3 , CH 3 , OCF 3 , CF 3 , OCF 3 , —CN, or C(O)CH 3 ; R 2 is H, Cl, CH 3 , OC (1-4) alkyl, or F; R 3 is H, F, Cl, CO 2 C (1-4) alkyl, C (1-4) alkyl, OC (1-4) alkyl, SC (1-4) alkyl, OCF 3 , OCH 2 CF 3 , —CN, CO 2 H, C(O)C (1-4) alkyl, C(O)NH 2 , C(O)NHC (1-4) alkyl, C(O)N(C (1-4) alkyl) 2 , or CF 3 ; R 4 is H, CH 3 , OC (1-4) alkyl, or F; or R 4 may be taken together with R 3 and their attached phenyl to form a bicyclic ring selected from the group consisting of 2,3-dihydro-1H-inden-5-yl, 2,3-dihydrobenzofuran-5-yl, 2,2-difluoro-benzo[d][1,3]dioxole-5-yl, 2,2-dimethyl-benzo[d][1,3]dioxole-5-yl, 2,2-difluoro-2,3-dihydrobenzofuran-5-yl, 2,2-dimethyl-2,3-dihydrobenzofuran-5-yl, chroman-6-yl, and 2,3-dihydrobenzo[b][1,4]dioxin-6-yl; X is H, OH, NH 2 , or F; Y is NH 2 ; Z is NH or —HC═CH—; and tautomers, and pharmaceutically acceptable salts thereof.