Patent ID: 7041465

Claim:
An isolated compound which inhibits pilus assembly, or a pharmaceutically-acceptable salt thereof, said compound comprising a mimic of a chaperone G1 beta-strand or a mimic of an amino terminal motif of a pilus subunit, wherein the mimic is a 10 to 20 residue peptide, having an amino terminus and a carboxy terminus, according to formula (I): Z 1 ˜Z 2 -X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -Z 3 ˜Z 4 (I) wherein: Z 1 is the amino terminus of the mimic peptide, Z 1 having the formula R—C(O)—NR— or RRN—; Z 2 is (i) a first peptide sequence consisting of 1 to 5 amino acid residues or (ii) a bond connecting Z 1 to X 1 ; X 1 is any amino acid residue; X 2 is any amino acid residue; X 3 is a hydrophobic residue or a hydroxyl-substituted aliphatic residue; X 4 is any amino acid residue; X 5 is a hydrophobic residue or Gly; X 6 is a hydrophobic or a hydrophilic residue; X 7 is Gly, an amide-substituted polar residue or a hydrophobic residue; X 8 is an amino acid residue other than an aliphatic residue; X 9 is an aliphatic residue; X 10 is any amino acid residue; Z 3 is (i) a second peptide sequence consisting of 1 to 5 amino acid residues or (ii) a bond connecting Z 4 to X 10 ; Z 4 is the carboxy terminus of the peptide, Z4 having the formula —C(O)OR or —C(O)NRR; each R is independently hydrogen, (C 1 –C 6 ) alkyl, (C 2 –C 6 ) alkenyl, (C 2 –C 6 ) alkynyl or (C 6 –C 14 ) aryl; each “-” between residues X 1 through X 10 , Z 2 and X 1 and X 10 and Z 3 independently represents an amide linkage, a substituted amide linkage or an isostere of an amide linkage; and each “˜” represents a bond.