Patent ID: 7445771

Claim:
A sterile, aqueous ophthalmic composition comprising a bis-amine of the following formula, in an amount effective to enhance the antimicrobial activity of the composition: wherein: R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of: H; —CH 2 OH; and C 1 -C 5 straight or branched alkyl or alkenyl, optionally containing one or more heteroatoms; provided that at least one of R1, R2, R3, R4, R5 and R6 is —CH 2 OH, and no more than two of R1, R2, R3, R4, R5 and R6 are CH 2 OH; and X is selected from the group consisting of: C 1 -C 16 saturated or unsaturated alkylene, optionally containing one or more heteroatoms; (—CH 2 —) w CHOH—CHOH(—CH 2 —) w , wherein w is a whole number of from 1 to 6 and the hydroxy groups are in either cis or trans configurations; (—CH 2 —O—CH 2 —) x , wherein x is a whole number of from 1 to 6; (—CH═CH—) y , wherein y is a whole number of from 1 to 6; and (—C≡C—) z , wherein z is a whole number from 1 to 6; or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle therefor, said composition having a physiologically compatible pH and an osmolality of 210 to 320 mOsm/kg.