Patent ID: 8119641

Claim:
A compound of formula (I): wherein A is an aryl or heteroaryl ring; NHZR 5 is at the ortho position to the CONH linker; R 1 and R 2 are the same or different and, independently from each other, represent a hydrogen atom, a straight or branched C 1 -C 3 alkyl, —CONH 2 , —CH 2 OR′ or —CH 2 NR′R″ or, taken together with the carbon atom to which they are bonded, R 1 and R 2 may form a C 3 -C 6 cycloalkyl group; R′ and R″ are the same or different and, independently from each other, represent a hydrogen atom or a straight or branched C 1 -C 3 alkyl group or, taken together with the nitrogen atom to which they are bonded, R′ and R″ may form a heterocyclic ring having one of the following formula wherein R′″ is a hydrogen atom or a straight or branched C 1 -C 3 alkyl group; R 3 is a hydrogen or halogen atom or a group selected from hydroxy, cyano, straight or branched C 1 -C 3 alkyl, C 1 -C 6 alkylamino and C 1 -C 3 alkoxy; R 4 is a hydrogen or halogen atom or a group selected from hydroxy, straight or branched C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, (1-methyl-piperazin-4-yl), (morpholino-4-yl), (azetidin-1-yl)methyl, (pyrrolidin-1-yl)methyl, (piperidin-1-yl)methyl, (1-methyl-piperazin-4-yl)methyl, (morpholino-4-yl)methyl, (1-methyl-piperidin-4-yloxy)methyl, (C 1 -C 6 alkylamino)methyl and (C 1 -C 6 di-alkylamino)methyl; Z is a direct bond, —(C═O)—, or —C(═O)NH—; R 5 is hydrogen or an optionally substituted group selected from C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 3 -C 6 cycloalkyl, aryl, heteroaryl and saturated heteroaryl; or optical isomers, tautomers and pharmaceutically acceptable salts thereof.