Patent ID: 8299063

Claim:
A compound selected from compounds of the following formula, and pharmaceutically acceptable salts thereof: wherein: —R 2 is independently —R 2B ; —R 3 is independently —H; —R 5 is independently —H; and -Z is independently -J 1 or J 2 ; wherein: —R 2B is independently pyrazolyl, and is optionally substituted with one or more substituents independently selected from: —R X1 , —F, —Cl, —Br, —OH, OR X1 , —CN, —NH 2 , —NHR X1 , or —NR X1 2 ; wherein each —R X1 is independently saturated aliphatic C 1-4 alkyl; wherein: -J 1 is independently a monocyclic non-aromatic heterocyclyl group having from 4 to 8 ring atoms, wherein exactly 1 of said ring atoms is a ring heteroatom, and is N, or exactly 2 of said ring atoms are ring heteroatoms, and are both N, or exactly 2 of said ring atoms are ring heteroatoms, and are N and O, or exactly 2 of said ring atoms are ring heteroatoms, and are N and S, and wherein said non-aromatic heterocyclyl group is optionally substituted; and -J 2 is independently a fused bicyclic non-aromatic heterocyclyl group having from 7 to 12 ring atoms, wherein exactly 1 of said ring atoms is a ring heteroatom, and is N, or exactly 2 of said ring atoms are ring heteroatoms, and are both N, or exactly 2 of said ring atoms are ring heteroatoms, and are N and O, or exactly 2 of said ring atoms are ring heteroatoms, and are N and S, or exactly 3 of said ring atoms are ring heteroatoms, one of which is N, and each of the other two is independently N, O, or S, and wherein said fused bicyclic non-aromatic heterocyclyl group is optionally substituted; wherein: each of -J 1 and J 2 is optionally substituted with one or more substituents independently selected from: substituents on carbon, independently selected from: —R Q , —R R , R L R R , F, —Cl, —Br, —OH, —R L —OH, —OR P , —R L —OR P , —NH 2 , —NHR P , —NR P 2 , and —CN; and substituents on nitrogen, if present, independently selected from: —R Q , —R R , —R L —R R , and —S(═O) 2 R P , wherein: each —R P is independently —Re, —R R , or —R L —R R ; each —R Q is independently saturated aliphatic C 1-4 alkyl, and is optionally substituted with one or more fluorine atoms; each —R R is independently phenyl, furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, or pyridazinyl, and is optionally substituted with one or more substituents independently selected from: —F, —Cl, —Br, —R K1 , —CF 3 , —OH, —OCF 3 , —NH 2 , —NHR K1 , —NR K 12 , and —CN; wherein each —R K1 is independently saturated aliphatic C 1-4 alkyl; and each —R L — is independently saturated aliphatic C 1-4 alkylene.