Patent ID: 7094896

Claim:
A compound of formula: or the pharmaceutically acceptable salts or esters thereof, wherein R 1 is selected from the group consisting of H, lower alkyl that optionally may be substituted with a group selected from OR 6 , cycloalkyl, and NR 7 R 8 , cycloalkyl, COR 9 , and SO 2 R 10 ; R 2 is selected from the group consisting of H, F, Cl, and CH 3 ; R 5 is selected from the group consisting of H, lower alkyl, which optionally may be substituted with a group selected from OR 6 and NR 7 R 8 , OR 11 , NR 12 R 13 , halogen, NO 2 , CONR 6 R 9 , NHSO 2 R 14 , CN S-lower alkyl, OCF 3 , and OCHF 2 , R 3 and R 4 taken together with the two carbons and the bond between them from the benzene ring (D) to which R 3 and R 4 are attached form a ring system having up to two additional rings, each of said rings having 5–7 atoms, and the ring attached to the benzene ring (D) optionally including one or more hetero atoms and being optionally substituted by lower alkyl, R 6 and R 9 are independently selected from the group consisting of H, and lower alkyl that optionally may be substituted by OH and halogen; R 7 and R 8 are independently selected from the group consisting of H, and lower alkyl that optionally may be substituted by OR 6 , or, alternatively, R 7 is H and R 8 is OH, or, alternatively, NR 7 R 8 can optionally form a ring having 5–6 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more of OR 6 and lower alkyl which itself may be optionally substituted by OH; R 10 is selected from the group consisting of lower alkyl which optionally may be substituted by one or more chlorine or fluorine, and NH 2 ; R 11 is selected from the group consisting of H, and lower alkyl that optionally may be substituted by OR 6 , COOH, halogen and NR 15 R 16 ; R 12 and R 13 are independently selected from the group consisting of H, lower alkyl that optionally may be substituted with a group selected from OR 6 , COOH and NR 15 R 16 , COR 17 , and SO 2 R 18 , provided that only one of R 12 and R 13 is COR 17 or SO 2 R 18 , or alternatively NR 12 R 13 can optionally form a ring having 5–6 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more of OR 6 and lower alkyl which itself may be optionally substituted by OH; R 14 is tower alkyl; R 15 and R 16 are independently selected from the group consisting of H, and lower alkyl that optionally may be substituted by OH, or alternatively NR 15 R 16 can optionally form a ring having 5–6 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more of OR 6 and lower alkyl which itself may be optionally substituted by OH; R 17 is selected from the group consisting of H, and lower alkyl which optionally may be substituted with a group selected from OH, COOH and NR 15 R 16 ; and R 18 is lower alkyl.