Patent ID: 8017115

Claim:
A method of promoting oligodendrocyte survival in a human suffering from stroke, which comprises administering to said human a therapeutically effective amount of an altered anti-myelin associated glycoprotein (anti-MAG) antibody or functional fragment thereof, wherein the altered antibody or functional fragment thereof binds to MAG and comprises: a heavy chain variable domain (V H ) which comprises in sequence hypervariable regions CDRH1 (SEQ ID NO: 4), CDRH2 (SEQ ID NO: 5), and CDRH3 (SEQ ID NO: 6) and a light chain variable domain (V L ) which comprises in sequence hypervariable regions CDRL1 (SEQ ID NO: 1), CDRL2 (SEQ ID NO: 2), and CDRL3 (SEQ ID NO: 3).