Patent ID: 8129394

Claim:
A compound of the following Formula: wherein Y is NR 4 ; R 1 is an optionally substituted heteroaryl ring selected from pyrimidine, triazine, pyrazine, pyridazine, or an optionally substituted bicyclic heteroaryl ring system, comprising pyrazinyl, pyridazinyl, triazinyl, or pyrimidinyl fused to a second ring selected from phenyl, pyrrole, pyrazole, triazole, imidazole, piperidine, piperidinone, pyrrolidine, and pyrrolidinone; R 2 is an optionally substituted pyrimidine, or an optionally substituted bicyclic group, comprising a pyrimidinyl ring fused to an additional cyclopentyl, cyclohexyl, pyrrole, imidazole, pyrazole, or piperidine ring; R 3 is optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted cycloalkyl; and R 4 is hydrogen or optionally substituted alkyl, including tautomers of the central imidazole ring when Y is NH or a stereoisomer or pharmaceutically acceptable salt thereof.