Patent ID: 8680282

Claim:
A compound represented by the following structural formula or a pharmaceutically acceptable salt thereof: wherein R 1 is —OH or —OC 1-6 alkyl; Z is —N + (R 4 R 5 )X − —; Q is —C(═O)—, —C(O)NH—, —S(O) 2 —, —S(O) 2 —NH—, or —S(O) 2 —N(R 3 )—; each of R 4 and R 5 independently is C 1-6 alkyl; X − is a pharmaceutically acceptable counter ion; n and m are each independently 1, or 2, R 2 is an aryl or an heteroaryl group selected from wherein each of rings A-O is optionally and independently substituted with one or more substituents selected from the group consisting of halogen, Ak 1 , Ar 1 , —NO 2 , —CN, —NCS, —C(O)OR 10 , —C(O)R 10 , —C(S)R 10 , —OC(O)R 10 , —C(O)N(R 11 ) 2 , —C(S)N(R 11 ) 2 , —S(O)R 12 , —S(O) 2 R 12 , —SO 2 N(R 11 ) 2 , —SO 2 N(R 11 )—NR 11 , —OR 10 , —SR 10 , —N(R 11 ) 2 , —NR 11 C(O)R 10 , —NR 11 S(O)R 12 , —NR 11 C(O)OR 12 , —N(R 11 )C(O)N(R 11 ) 2 , —NR 11 SO 2 N(R 11 ) 2 , —NR 11 SO 2 R 12 , —O—[CH 2 ] p —O—, —S—[CH 2 ] p —S— and —[CH 2 ] q —; or wherein: Ak 1 is a C 1-20 aliphatic group each R 10 independently is a C 1-20 aliphatic group; each R 11 independently is R 10 , —CO 2 R 10 , —SO 2 R 10 or —C(O)R 10 , or —N(R 11 ) 2 taken together is an optionally substituted non-aromatic heterocyclic group; and each R 12 independently is a C 1-20 aliphatic group; Ar 1 is a C 6-14 aryl or a 5-14 membered heteroaryl group; each p independently is 1, 2, 3 or 4; each q independently is 3, 4, 5 or 6; each R 3 independently is an unsubstituted C 1 -C 10 alkyl group.