Patent ID: 7427632

Claim:
A compound of formula (I) in which: R 1 represents a group of formula in which X represents CH; R 2 represents a hydrogen atom or a (1-6C)alkyl, (3-6C)cycloalkyl, fluoro(1-4C)alkyl, fluoro(2-4C)alkanoyl, hydroxy(2-4C)alkyl or pyridyl group; n represents 1, 2 or 3; Z represents CH 2 , O or NR 5 , in which R 5 represents a hydrogen atom or a (1-4C)alkyl group; R 3 represents: (i) phenyl which is unsubstituted or substituted by methylenedioxy or by a substituent selected from halogen, (1-4C)alkyl, hydroxy, (1-4C)alkoxy, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (1-4C)alkylthio, (1-4C)alkylsulfinyl, (1-4C)alkylsulfonyl, carboxy, aminocarbonyl, amino, (2-4C)alkanoylamino, aminosulfonyl, (1-4C)alkylaminosulfonyl, nitro, phenyl, phenoxy, benzyloxy and pyridyl; (ii) pyridyl, pyrimidyl or pyridazinyl, which is unsubstituted or substituted by a halogen atom; (iii) furyl, thienyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, each of which is unsubstituted or substituted by (1-4C)alkyl or amino; (iv) naphthyl, benzofuryl, benzothienyl, quinolyl or isoquinolyl; (v) (3-6C)cycloalkyl; (vi) piperidinyl or tetrahydropyranyl; or (vii) (1-4C)alkyl, which is unsubstituted or substituted by hydroxy, (1-4C)alkoxy, phenoxy, carboxy, aminocarbonyl, aminosulfonyl, (1-4C)alkylthio, phenylthio, pyridylthio, amino, (1-4C)alkylamino, di(1-4C)alkylamino, piperidin-1-yl, morpholino, trifluoromethyl, phenyl, imidazolyl, pyridyl, (3-6C)cycloalkyl, oxa(4-6C)cycloalkyl, or aza(4-6C)cycloalkyl (which may bear an N-(1-4C)alkyl substituent); and R 4 is selected from in which X 1 represents a hydrogen atom, a halogen atom or an amino group; X 2 represents a hydrogen atom, a methyl group, a chlorine atom or a bromine atom; X 3 represents a hydrogen atom, a methyl group or a halogen atom; X 4 represents a chlorine atom, a methoxy group or a methyl group; and X 5 represents a hydrogen atom, a halogen atom or a methyl group; or a pharmaceutically acceptable salt thereof.