Patent ID: 7793655

Claim:
A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation, comprising: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable to store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; a cannula guide extending from the upper end of the displacing device to the cartridge chamber; a first pierceably sealed opening disposed between the cartridge chamber and the guide; and a second pierceably sealed opening disposed between the cartridge chamber and the container, which is sealed with a sealing film including one or more frangible points between the sealing film and a periphery of the second opening such that when the first opening is pierced by pressure, the sealing film tears at the one or more frangible points, wherein insertion of a cannula through the guide pierces the first pierceably sealed opening causing the second pierceably sealed opening to open and releases pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.