Patent ID: 8058244

Claim:
A method of inhibiting DNA synthesis in human pancreatic cancer cells, said method comprising: providing a compound of formula wherein each of R 1 -R 5 is independently selected from H and alkyl moieties; X 1 is selected from O and NR 4 ; R 1 â€² is X 2 ArCH 2 â€”, wherein X 2 is selected from Br, Cl and alkyl, and Ar is selected from aryl and heteroaromatic moieties; and each of R 2 â€²-R 5 â€² is independently selected from R 1 â€², CH 3 â€”, (CH 3 ) 2 CHâ€”, (CH 3 ) 2 CHCH 2 â€”, CH 3 CH 2 (CH 3 )CHâ€” and CH 3 S CH 2 CH 2 â€” moieties; and contacting human pancreatic cancer cells with said compound, said compound in an amount sufficient for said inhibition measurable by reduction of thymidine incorporation into said cells.