Patent ID: 8354434

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein: Z is Z 1 , wherein R 1 and R 2 are both hydrogen or R 1 and R 2 , together with the carbon atoms to which they are attached, form a fused cyclopropyl ring; R 3 is selected from the group consisting of (i) hydrogen; (ii) alkyl; (iii) C 3-6 cycloalkyl; (iv) —(CH 2 ) p —Y; R 4 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, cyano, amino, aminoalkyl, alkylamino, and dialkylamino; R 9 and R 10 are each independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, cyano, hydroxy, and hydroxyalkyl; R 11 and R 12 are each independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, cyano, hydroxy, and hydroxyalkyl; wherein Y is a 3-7 membered saturated heterocyclic ring optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, cyano, hydroxy, and hydroxyalkyl; m is 0, 1, 2, 3, 4, or 5; p is 0, 1, 2, 3, or 4; q and s are each independently 0, 1, 2, 3, 4, or 5; r is 0 or 1; t is 1, 2, 3, or 4; and u is 0, 1, 2, 3, or 4.