Patent ID: 8105588

Claim:
A method of treating an inflammatory skin disorder mediated by human IL-8 comprising administering to a subject an effective amount of a monoclonal antibody which binds to human IL-8, wherein the antibody comprises heavy and light chain variable regions comprising CDR1, CDR2, and CDR3 sequences, wherein the heavy and light chain variable region CDR2 sequences comprise the amino acid sequences set forth in SEQ ID NOs:23 and 17, respectively, the heavy and light chain variable region CDR1 sequences comprise the amino acid sequences set forth in SEQ ID NOs:22 and 16, respectively, and wherein the heavy chain CDR3 sequence comprises the amino acid sequence set forth in SEQ ID NO:24 or the amino acid sequence Asp-X 4 -Val-Gly-X 5 -Phe-Asp-Tyr (SEQ ID NO: 47), wherein X 4 is Lys, Arg, or His, and X 5 is Gly, Ala, Val, Leu, or Ile, and the light chain variable region CDR3 sequence comprises the amino acid sequence set forth in SEQ ID NO:18 or the amino acid sequence Gln-Gln-Tyr-X 1 -X 2 -Ser-X 3 -Thr (SEQ ID NO: 46), wherein X 1 , X 2 and X 3 each represents a natural amino acid residue, and X 1 is different from Gly, or X 2 is different from Ser, or X 3 is different from Pro.