Patent ID: 7598250

Claim:
A compound having the structural formula or a pharmaceutically acceptable salt thereof, wherein R 1 is X is —O—, —C(R 14 ) 2 — or —N(R)—; Z is —C(R 14 ) 2 — or —N(R)—; t is 0, 1, 2 or 3; each R is independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl, phenylalkyl, alkenyl, pyridylmethyl, furanylmethyl, thienylmethyl, thiazolylmethyl, cycloalkyl, and cycloalkylalkyl, wherein said alkyl, said alkoxy, said alkoxyalkyl, said phenylalkyl, said alkenyl, said pyridylmethyl, said furanylmethyl, said thienylmethyl, said thiazolylmethyl, said cycloalkyl, and said cycloalkylalkyl are unsubstituted or substituted by from 1 to 5 independently selected R 32 groups; R 2 is H, alkyl, phenyl, or phenylalkyl, wherein said phenyl and said phenylalkyl are unsubstituted or substituted by from 1 to 5 independently selected R 32 groups; R 3 is H or alkyl; R 4 is H or alkyl; R 5 is H or alkyl; each R 14 is independently selected from the group consisting of H, alkyl, alkenyl, halo, —CN, haloalkyl, phenyl, phenylalkyl, cycloalkyl, R 41 is alkyl, cycloalkyl, —SO 2 (alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH 3 ; R 6 and R 7 are independently selected from the group consisting of H and alkyl, or R 6 and R 7 , together with the ring carbon to which they are attached, form —C(O)—; R 8 and R 9 are independently selected from the group consisting of H and alkyl, or R 8 and R 9 , together with the ring carbon to which they are attached, form —C(O)—; R 12 and R 13 are independently selected from the group consisting of H and alkyl, wherein said alkyl is unsubstituted or substituted by from 1 to 5 independently selected R 32 groups, or R 12 and R 13 , together with the ring carbon to which they are attached, form —C(O)—; R 18 is H, alkyl, phenyl, phenylalkyl, pyridyl, oxazolyl, pyrazinyl, thienyl, imidazolyl, pyridylalkyl, oxazolylalkyl, pyrazinylalkyl, thienylalkyl, or imidazolylalkyl, wherein said alkyl, said phenyl, said phenylalkyl, said pyridyl, said oxazolyl, said pyrazinyl, said thienyl, said imidazolyl, said pyridylalkyl, said oxazolylalkyl, said pyrazinylalkyl, said thienylalkyl, and said imidazolylalkyl, are each unsubstituted or substituted by from 1 to 4 independently selected R 32 groups; R 19 is H, alkyl, phenyl, phenylalkyl, pyridyl, oxazolyl, pyrazinyl, thienyl, imidazolyl, pyridylalkyl, oxazolylalkyl, pyrazinylalkyl, thienylalkyl, or imidazolylalkyl, —SOR 18 , —SO 2 R 18 or —CN, wherein said alkyl, said phenyl, said phenylalkyl, said pyridyl, said oxazolyl, said pyrazinyl, said thienyl, said imidazolyl, said pyridylalkyl, said oxazolylalkyl, said pyrazinylalkyl, said thienylalkyl, and said imidazolylalkyl, are each unsubstituted or substituted by from 1 to 4 independently seiected R 32 groups; and each R 32 group is independently selected from the group consisting of halo, alkyl, alkoxy, —OH, phenyl, phenoxy, phenylalkyl, —NO 2 , —CN, haloalkyl, and haloalkoxy, or two R 32 groups on the same ring carbon atom are taken together to form ═O.