Patent ID: 7598397

Claim:
A compound of formula wherein A and B represent a six-membered carbocycle fused to a five-membered nitrogen heterocycle, said A/B ring system chosen from indole, reduced indole, 2-oxoindole, and reduced 2-oxoindole, and said fused A/B ring system substituted with from zero to four substituents chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl, hydroxylloweralkyl, oxo, oxide, —CN, nitro, —S-loweralkyl, amino, loweralkylamino, diloweralkylamino, diloweralkylaminoalkyl, carboxy, carboalkoxy, orthoester, acyl, acylalkyl, carboxamido, loweralkylsulfoxide, loweralkylsulfone, acylamino, phenyl, benzyl, spirothiazolidinyl, phenoxy and benzyloxy; a and b represent points of attachment of residues Y and W respectively and a and b are in a peri relationship to one another on said fused A/B ring system; d and e represent points of fusion between ring A and ring B in said fused A/B ring system; Each of the nodes a, b, d and e may be either carbon or nitrogen; W is chosen from —CH 2 O—, —OCF 2 —, —OC(CH 3 )—, —CH=CH—, and —NHCH 2 ; Y is chosen from —CH 2 —, —O—, —OCH 2 —, —S—, —SO—, and —SO 2 —; M is chosen from aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl wherein substituents on substituted aryl and heterocyclyl are chosen from halogen, loweralkyl, haloalkyl, hydroxy, loweralkoxy. carboxy, carboalkoxy, carboxamido, cyano, carbonyl, nitro, amino, alkylamino, dialkylamino, mercapto, alkylthio, sulfoxide, sulfone, acylamino, amidino, phenyl, benzyl, heteroaryl, phenoxy, benzyloxy, and heteroaryloxy; Q is chosen from —N(SO 2 R 1 )—, —N(COR 1 )—, —N(CO 2 R 1 )—, —N[PO(O-alkyl) 2 ]—, and —NHNR 10 (SO 2 R 1 )—; R 1 is chosen from phenyl, isoxazole, thienyl, substituted isoxazole, substituted thienyl, C 3 -C 20 alkyl and fluoroalkyl; and R 10 is chosen from alkyl, aryl and heteroaryl.