Patent ID: 8071316

Claim:
A method for diagnosing Celiac Sprue in an individual, said method comprising: contacting a biological sample comprising a tissue, bodily fluid, or stool from said individual with a gluten oligopeptide having the amino acid sequence LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF (SEQ ID NO:12) or a deamidated counterpart thereof comprising one or more deamidated glutamine residues, wherein at least one deamidated glutamine residue is at position 10 or position 24 of SEQ ID NO:12; and detecting the presence of an antibody that specifically binds to said gluten oligopeptide; wherein the presence of increased levels of said antibody that binds to said gluten oligopeptide, relative to a normal control, is indicative of Celiac Sprue in said individual.