Patent ID: 7067525

Claim:
A compound of formula (I), or a pharmaceutically-acceptable salt or hydrate, thereof, in which: R 1 is hydrogen or C 1-6 alkyl; R 2 is C 1-6 alkyl or C 2-6 alkenyl optionally substituted with one to three aryl, cycloalkyl, or heteroaryl, provided that where G is —NR 18 CO 2 R 19 , or when y is 0, R 2 is C 1-6 alkyl or C 2-6 alkenyl, each optionally substituted with heteroaryl; E is G is selected from —NR 18 C(═O)R 19 —NR 18 SO 2 R 17 , —NR 18 CO 2 R 19 , and —NR 20 C(═O)NR 18 R 19 , or where G is —NR 18 CO 2 R 19 , or when y is 0, R 2 is C 1-6 alkyl or C 2-6 alkenyl, each optionally substituted with heteroaryl; W is selected from substituted or unsubstituted heterocyclo, or heteroaryl, selected from azetidinyl and imidazolyl, each optionally substituted with lower alkyl; R 13 , R 14 , R 15 and R 16 are hydrogen; R 17 is alkyl, substituted alkyl, cycloalkyl, aryl, heterocyclo, or heteroaryl; R 18 , R 19 , and R 20 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, heterocyclo, or C(═O)R 28 ; or when G is NH(C═O)R 19 , R 19 may be a bond joined to W to define a heterocyclo ring; provided, however, that when y is at least one, W is imidazolyl, and G is —NR 18 C(═O)R 19 , then R 19 is not a C 1 -alkyl having the substituent —NR 29 R 31 ; x is 0, 1, or 2; and y is 0, 1, 2, 3 and 4.