Patent ID: 8470361

Claim:
A particulate transmucosal pharmaceutical composition in the form of a tablet suitable for sublingual administration comprising a pharmacologically-effective amount of an opioid analgesic, or a pharmaceutically-acceptable salt thereof, presented in particulate form upon the surfaces of carrier particles comprising a pharmacologically-effective amount of an opioid antagonist, or a pharmaceutically-acceptable salt thereof, which carrier particles are larger in size than the particles of the opioid analgesic, wherein both of said opioid analgesic and said opioid antagonist are delivered transmucosally, wherein the dose of opioid analgesic active ingredient per unit dosage form is in the range of between about 1 μg and about 20 mg, and the dose of opioid antagonist active ingredient per unit dosage form is in the range of between about 0.1 mg and about 4 mg, and wherein the opioid analgesic is selected from the group consisting of fentanyl, alfentanil, sufentanil, remifentanil and buprenorphine, and the opioid antagonist is selected from the group consisting of nalmefene, methylnaltrexone, naltrexone and naloxone.