Patent ID: 8410110

Claim:
A process for the inhibition of Bax in a patient in need thereof, the process comprising: administering, in an amount sufficient to inhibit Bax in the patient, a compound of formula (I): as well as a pharmaceutically acceptable salt thereof, in racemic form or in an enantiomeric excess, wherein: R 0 and R 1 are selected independently from each other and are hydrogen; halogen; cyano; sulfonyl of formula —SO 2 —R, wherein R is hydrogen, aryl, heteroaryl, C 1-6 alkyl, or C 1-6 alkyl substituted with a halogen; sulfoxy; substituted or unsubstituted C 1 -C 6 -thio-alkoxy; nitro; primary, secondary or tertiary amine or sulfonamide; aminocarbonyl; amino-thiocarbonyl; hydroxy; substituted or unsubstituted C 1 -C 6 -alkoxy; aryloxy; heteroaryloxy; carboxylic amide; alkoxycarbonyl; carboxylic ester; carboxylic acid; substituted or unsubstituted C 1 -C 6 -alkyl carbonyl; substituted or unsubstituted arylcarbonyl or heteroarylcarbonyl; substituted or unsubstituted saturated or unsaturated C 3 -C 8 -cycloalkylcarbonyl; substituted or unsubstituted C 1 -C 6 -alkyl; substituted or unsubstituted C 2 -C 6 -alkenyl; substituted or unsubstituted C 2 -C 6 -alkynyl; substituted or unsubstituted aryl or heteroaryl; or substituted or unsubstituted 3-8 membered saturated or unsaturated cyclic alkyl; R 2 is hydrogen, substituted or unsubstituted C 1 -C 6 -alkyl, substituted or unsubstituted C 2 -C 6 -alkenyl, substituted or unsubstituted C 2 -C 6 -alkynyl, substituted or unsubstituted aryl or heteroaryl, substituted or unsubstituted 3-8 membered saturated and unsaturated cyclic alkyl, sulfoxy, sulfonyl of formula —SO 2 —R, sulfonamide, carboxylic amide, aminocarbonyl, alkoxycarbonyl, hydrazine acyl, substituted or unsubstituted carbonyl-C 1 -C 6 -alkyl, substituted or unsubstituted arylcarbonyl or heteroarylcarbonyl, substituted or unsubstituted saturated or unsaturated C 3 -C 8 -cycloalkylcarbonyl, alkoxy, or C 1 -C 6 -thioalkoxy; R 3 is hydrogen, halogen, substituted or unsubstituted C 1 -C 6 -alkyl, substituted or unsubstituted C 2 -C 6 -alkenyl, substituted or unsubstituted C 2 -C 6 -alkynyl, substituted or unsubstituted aryl or heteroaryl, substituted or un-substituted 3-8 membered saturated and unsaturated cyclic alkyl, alkoxycarbonyl, carboxylic amide, C 1 -C 6 -alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryloxy, hydroxy, substituted or unsubstituted C 1 -C 6 -alkyl carbonyl, substituted or unsubstituted arylcarbonyl or heteroarylcarbonyl, substituted or unsubstituted saturated or unsaturated C 4 -C 8 -cycloalkylcarbonyl, or an oxo (═O) group; k and l are independently from each other an integer from 0 to 4; X is a group of the formula —(CR′R″)—, wherein R′ is halogen and R″ is hydrogen or halogen; m and n are independently from each other an integer from 1 to 3; and o is an integer from 0 to 8.