Patent ID: 7906649

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein each n is independently 0, 1, 2, or 3; X is selected from the group consisting of : Ar is phenyl unsubstituted or substituted with one to five R 1 substituents; each R 1 is independently selected from the group consisting of halogen, cyano, hydroxy, C 1-6 alkyl, unsubstituted or substituted with one to five halogens, C 1-6 alkoxy, unsubstituted or substituted with one to five halogens, carboxy, C 1-6 alkyloxycarbonyl, amino, NHR 2 , NR 2 R 2 , NHSO 2 R 2 , NR 2 SO 2 R 2 , NHCOR 2 , NR 2 COR 2 , NHCO 2 R 2 , NR 2 CO 2 R 2 , SO 2 R 2 , SO 2 NH 2 , SO 2 NHR 2 , and SO 2 NR 2 R 2 ; each R 2 is independently C 1-6 alkyl, unsubstituted or substituted with one to five substituents independently selected from halogen, CO 2 H, and C 1-6 alkyloxycarbonyl; R 3 is selected from the group consisting of hydrogen, hydroxy, halogen, cyano, CO 2 H, NR 4 R 5 , CONR 4 R 5 , CH 2 CONR 4 R 5 , OCONR 4 R 5 , SO 2 NR 4 R 5 , SO 2 R 6 , NR 7 SO 2 R 6 , NR 7 CONR 4 R 5 , NR 7 COR 6 , NR 7 CO 2 R 6 , 1H-tetrazol-5-yl, C 1-6 alkyloxycarbonyl, C 1-6 alkyl unsubstituted or substituted with hydroxy or one to five halogens, C 1-6 alkoxy unsubstituted or substituted with hydroxy or one to five halogens, C 1-6 alkylthio, C 1-6 alkylsulfonyl, and (CH 2 ) n -C 3-6 cycloalkyl, wherein cycloalkyl is unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, and C 1-4 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to five halogens; wherein any individual methylene (CH 2 ) carbon atom in (CH 2 ) n is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, C 1-4 alkyl, and C 1-4 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to five halogens; R 4 and R 5 are each independently selected from the group consisting of hydrogen, (CH 2 ) n -phenyl, (CH 2 ) n -C 3-6 cycloalkyl, and C 1-6 alkyl, wherein alkyl is unsubstituted or substituted with one to five substituents independently selected from halogen and hydroxy and wherein phenyl and cycloalkyl are unsubstituted or substituted with one to five substituents independently selected from halogen, hydroxy, C 1-6 alkyl, and C 1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to five halogens; or R 4 and R 5 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from azetidine, pyrrolidine, piperidine, piperazine, and morpholine wherein said heterocyclic ring is unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-6 alkyl, and C 1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to five halogens; each R 6 is independently C 1-6 alkyl, wherein alkyl is unsubstituted or substituted with one to five substituents independently selected from halogen and hydroxyl; and R 7 is hydrogen or R 6 .