Patent ID: 8497384

Claim:
A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula:CR 1 R 2 , in a reaction vessel, optionally in the presence of a solvent, wherein, R 1 and R 2 are each independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R 7 or —NR 8 2 ; R 3 , R 4 , R 5 and R 6 are each independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R 9 , —NR 10 2 , —SR 11 , —S(O)R 11 , or —SO 2 R 11 , or R 3 and R 6 are as defined above and R 4 and R 5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R 7 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl, aryloxy, heteroaryl or —NR 10 2 ; R 8 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R 9 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl, aryloxy or heteroaryl; R 10 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R 12 ; R 11 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and R 12 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process.