Patent ID: 8648198

Claim:
A compound of Formula (I-c): or a pharmaceutically acceptable salt thereof, wherein: X is CH; each instance of R 6 is independently selected from the group consisting of substituted hydroxyl, substituted thio, silyl, halo, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, provided at least two R 6 groups ortho to each other are joined to form an optionally substituted pyrrolyl ring; x is an integer between 2 and 5, inclusive; y is 0 or 1; and m is 1 or 2; wherein the compound stabilizes the molecular conformation of hydrophobic residues GluN1b A74, GluN2B I82, and GluN2B F114 of the NMDA receptor.