Patent ID: 8679460

Claim:
An injectable radiological composition for x-ray visualization during radiological examinations, the composition comprising a pharmaceutically acceptable vehicle and a mixture of at least one monomer and at least one dimer, the monomer corresponding to Formula I and the dimer corresponding to Formula II wherein, with regard to Formula I: A 1 and B 1 are —CON(R 3 )R 1 ; D 1 is —N(R)C(O)R 2 ; each R and R 2 is independently H, or a linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted by one or more hydroxy, alkoxy or hydroxyalkoxy groups or combinations thereof; each R 1 is independently (i) hydrogen, or (ii) a linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted with one or more hydroxy, alkoxy, hydroxyalkoxy groups or combinations thereof; each R 3 is independently linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted with one or more hydroxy, alkoxy or hydroxyalkoxy groups or combinations thereof; and wherein with regard to Formula II: A 2 and A 3 are —CONH 2 ; B 3 and D 2 are —CON(R)R 1 ; E 2 and E 3 are independently selected from the group consisting of —CON(R)—, —N(R)C(O)—and —N(COR 2 )—; each R is independently H, or a linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted by one or more hydroxyl, alkoxy or hydroxyalkoxy groups or combinations thereof; each R 1 is independently (i) hydrogen, (ii) a linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted by one or more hydroxyl, alkoxy or hydroxyalkoxy groups or combinations thereof, or (iii) the residue of a carbohydrate; or R and R 1 are each members of a (C 3 -C 7 ) cyclic residue further comprising the nitrogen atom to which each of R and R 1 is bonded, said cyclic residue being optionally interrupted by —O—, —S— or —NR 4 —, and/or optionally substituted by one or more hydroxy, alkoxy or hydroxyalkoxy groups or combinations thereof; each R 2 is independently a linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted by one or more hydroxyl, alkoxy or hydroxyalkoxy groups or combinations thereof; each R 4 is independently hydrogen or a linear or branched (C 1 -C 8 ) alkyl residue, optionally substituted by one or more hydroxyl, alkoxy or hydroxyalkoxy groups or combinations thereof; and X is a bond or a linear or branched (C 1 -C 8 ) alkylene chain which is optionally substituted by up to six hydroxyl groups, said alkylene chain being optionally interrupted by —O—, —S—, —NR 4 — or —N(R)C(O)— groups.