Patent ID: 7763612

Claim:
A therapeutic amine-arylsulfonamide conjugate compound, comprising structure (I): wherein R′ is [D-W-], hydroxyl, or alkoxyl; R″ is independently [D-W′-], hydrogen, alkyl, or alkoxyl; D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W′ by a nitrogen or oxygen atom; W and W′ are a chemical bond or linker; wherein either R′ is [D-W-] or at least one R″ is [D-W′-]; and pharmaceutically acceptable esters, amides, salts or solvates thereof; wherein the therapeutic amine radical is derived from amines selected from the group consisting of: manifaxine; 2-(1-(3,5-difluorobenzoyl)-(R,S)-ethylamino)-(R)-2-methylethanol; (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol; radafaxine; 2-(1-(3-chlorobenzoyl)-(R,S)-ethylamino)-2,2-dimethylethanol; bupropion; citalopram; escitalopram; paroxetine; fluoxetine; fluvoxamine; sertraline; phenelzine; tranylcypromine; amitriptyline; amoxapine; clomipramine; desipramine; doxepine; imipramine; nortryptyline; protriptyline; trimipramine; maprotiline; mirtazapine; duloxetine; nefazodone; trazodone; and venlafaxine.