Patent ID: 8865885

Claim:
A pharmaceutical composition for treating a subject exhibiting a cancer and/or a myeloproliferative disorder associated with overexpression of a transcription factor gene product from the homeobox gene family (HOXA1), wherein the cancer and/or myeloproliferative disorder is selected from the group consisting of: acute myeloid leukemia (AML), acute megakaryoblastic leukemia (AMKL), multiple myeloma (MM), and chronic myelogenous leukemia (CML), the composition comprising an effective amount of at least one miR-10a gene product and a pharmaceutically-acceptable carrier, wherein the at least one miR-10a gene product binds to, and decreases expression of, the HOXA1 gene product in the subject, wherein the at least one miR-10a gene product comprises one or more chemical modifications selected from the group consisting of: sugar modifications, backbone modifications, and combinations thereof; and wherein the subject has been diagnosed with acute myeloid leukemia (AML).