Patent ID: 8299023

Claim:
A neuropeptide-2 receptor agonist of the formula (I): Y—R 1 —R 2 —X—R 3 —R 4 —R 5 —R 6 —R 7 —R 8 —R 9 —R 10 —R 11 —R 12 —R 13 —R 14 —NH 2 (I) (SEQ ID NO: 1), wherein: X is (4-Aminomethyl-biphenyl-3-yl)-acetic acid (Cba), (5-piperazin-1-yl-indole-1-yl)-acetic acid (Cip), 3-(4-oxo-6-piperazin-1-yl-4H-quinazolin-3-yl)-propionic acid (HomPqa), (6-[1,4]diazepan-1-yl-4-oxo-4H-quinazolin-3-yl)-acetic acid (Dqa), (6-Oxo-2-piperazin-1-yl-1,6-dihydropurin-7-yl)-acetic acid (Pdp), (2-Piperazin-1-yl-purin-7-yl)-acetic acid (Ppa), (6-Amino-2-piperazin-1-yl-9H-purin-8-yl)-acetic acid (Appa), ((1R,4S)-6-2-Aza-bicyclo[2.2.1]hept-5-yl-4-oxo-4H-quinazolin)-acetic acid (Bqa) or, (1-Oxo-7-piperazin-1-yl-1H-isoquinolin-2-yl)-acetic acid (Pipa), Y is H or an acyl moiety, R 1 is Ile, Ala, (D)Ile, N-methyl Ile, Aib, 1-1Aic, 2-2 Aic, Ach or Acp, R 2 is Lys, Ala, (D)Lys, N-methyl lys, Nle or (Lys-Gly), R 3 is Arg, Ala, (D)Arg, N-methyl Arg, Phe, 3,4,5-Trifluoro Phe or 2,3,4,5,6-Pentafluoro Phe, R 4 is His, Ala, (D)His, N-methyl His, 4-MeOApc, 3-Pal or 4-Pal, R 5 is Tyr, Ala, (D)Tyr, N-methyl Tyr, Trp, Tic, Bip, Dip, (1)Nal, (2)Nal, 3,4,5-TrifluoroPhe or 2,3,4,5,6-Pentafluoro Phe, R 6 is Leu, Ala, (D)Leu or N-methyl Leu, R 7 is Asn, Ala or (D)Asn, R 8 is Leu or Trp, R 9 is Val, Ala, (D)Val or N-methyl Val, R 10 is Thr, Ala or N-methyl Thr, R 11 is Arg, (D)Arg or N-methyl Arg, R 12 is Gln or Ala, R 13 is Arg, (D)Arg or N-methyl Arg, and R 14 is Tyr, (D) Tyr or N-methyl Tyr, Phe, (1) Nal, (2) Nal, Cha, C-alpha-methyl Tyr, or Trp, or a pharmaceutically acceptable salt thereof.