Patent ID: 8906867

Claim:
A production method of a solid preparation, comprising: dissolving a water-insoluble alkaline active pharmaceutical ingredient in an acidifier-containing acid solution to obtain a medicated acid liquid; then homogeneously mixing an alkalizer, adjuvants and the medicated acid liquid, and carrying out wet granulation, wherein the water-insoluble alkaline active pharmaceutical ingredient is eszopiclone, diazepam, estazolam, alprazolam, zopiclone, aripiprazole, risperidone, mifepristone, perphenazine, digoxinum, agomelatine, iloperidone, paliperidone, olanzapine, haloperidol, dipyridamole, carbimazole, metoclopramide, minoxidil or reserpine, and the alkalizer is a reagent that reduces the acidity of the medicated acid liquid.