Patent ID: 7833730

Claim:
A method for identifying a Glucose-dependent Insulinotropic Peptide (GIP) secretagogue, comprising: (a) contacting in vitro a test compound with a host cell expressing a G Protein-Coupled Receptor (GPCR), or with a membrane of a host cell expressing a GPCR, wherein the GPCR comprises an amino acid sequence selected from the group consisting of: (i) SEQ ID NO:2; and (ii) an amino acid sequence of a GPCR encoded by the nucleotide sequence set forth in SEQ ID NO:1; (b) determining the ability of the test compound to stimulate functionality of the GPCR; (c) administering the test compound that stimulates functionality of the GPCR in step (b) to a mammal; and (d) determining whether the test compound increases a blood GIP level in the mammal; wherein the ability of the test compound to increase a blood GIP level in the mammal identifies the test compound as a GIP secretagogue.