Patent ID: 8293914

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein one or two of X 1 , X 2 , X 3 , X 4 and X 5 is NH, and the others are each CR 3 ; R 1 and R 2 are each selected from the group consisting of (1) hydrogen, or (2) fluoro; R 3 is selected from the group consisting of (1) hydrogen, (2) halogen, (3) cyano, (4) —C 1-6 -alkyl, (5) —OC 1-6 -alkyl, (6) —C 3-8 cycloalkyl, (7) —C 6-10 aryl, (8) heteroaryl group having 5 to 12 ring atoms, (9) —NR 6A R 6B , (10) —S(O) m —R 5A , wherein any alkyl, aryl, heteroaryl, and cycloalkyl R 3 moiety is optionally substituted with one or more (a) halogen, (b) hydroxy, (c) cyano, (d) —(CH 2 ) q -aryl, (e) —O—C 1-6 alkyl, (f) —C 1-6 alkyl, (g) —(CH 2 ) p —NR 6C R 6D , (h) —C 3-8 cycloalkyl, (i) heteroaryl group having 5 to 12 ring atoms, (j) —C(═O)—OR 5A , (k) —C(═O)—R 5A , (l) —S(O) m —R 5A , (m) —C(═O)—NR 6A R 6B , (n) —NR 5A SO 2 —R 5B , (o) —NR 5A C(═O)R 5B , (p) —NR 5A C(═O)—O—R 5B , and wherein said alkyl, aryl or heteroaryl moiety is optionally substituted with one or more (i) halogen, (ii) hydroxy, or (iii) cyano; R 4 is selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, and (3) —CH 2 -aryl, wherein said R 3 alkyl or aryl moiety is optionally substituted with one or more (a) halogen, (b) cyano, and (c) —O—C 1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo; R 5A and R 5B are independently selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, and (3) —(CH 2 ) n -aryl, wherein said R 5A or R 5B alkyl or aryl moiety is optionally substituted with one or more (a) halogen, (b) cyano, and (c) —O—C 1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo; R 6A , R 6B , R 6C and R 6D are selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, (3) —C 3-6 cycloalkyl, or R 6A and R 6B , or R 6C and R 6D are linked together with the nitrogen to which they are both attached to form a 3-6 membered carbocyclic ring, wherein one or two of the ring carbon atoms is replaced by a nitrogen, oxygen or sulfur; m is 0, 1 or 2; n is 0 or 1; p is 0 or 1; and q is 0 or 1.