Patent ID: 7119089

Claim:
A method of inhibiting KSP kinesin in vitro comprising contacting KSP kinesin with a compound of formula wherein R 1 is hydrogen, halogen or CF 3 ; R 2 is chosen from hydrogen and lower alkyl; R 5 is chosen from hydrogen, alkyl, substituted alkyl, alkylaryl, substituted alkylaryl, alkylheteroaryl and substituted alkylheteroaryl; or R 3 and R 4 taken together with the intervening atoms form five- to seven-membered heterocycloalkyl ring chosen from imidazoline, piperidine, piperazine, pyrrolidine, pyrazole, pyrrole, tetrazole, and morpholine, said ring optionally substituted with one or more alkyl, aryl, alkoxy, halo, alkylaryl or substituted alkylaryl substituents, or a pharmaceutically acceptable salt thereof.