Patent ID: 8168409

Claim:
An isolated polynucleotide comprising a nucleotide sequence, or its complement, wherein said nucleotide sequence encodes the light chain, the heavy chain, or both the light chain and the heavy chain of an anti-IGF-1R antibody or an antigen binding fragment of said anti-IGF-1R antibody, wherein: a. the light chain variable region of said anti-IGF-1R antibody or antigen binding fragment comprises the amino acid sequence of SEQ ID NO:32 and the heavy chain variable region of said anti-IGF-1R antibody or antigen binding fragment comprises the amino acid sequence of SEQ ID NO:136; or b. the light chain variable region of said anti-IGF-1R antibody or antigen binding fragment comprises: i. the CDR 1 sequence of residues 24 through 39 of SEQ ID NO:32; and ii. the CDR 2 sequence of residues 55 through 61 of SEQ ID NO:32; and iii. the CDR 3 sequence of residues 94 through 102 of SEQ ID NO:32; and the heavy chain variable region of said anti-IGF-1R antibody or antigen binding fragment comprises: i. the CDR 1 sequence of residues 31 through 36 of SEQ ID NO:136; and ii. the CDR 2 sequence of residues 51 through 66 of SEQ ID NO:136; and iii. the CDR 3 sequence of residues 99 through 108 of SEQ ID NO:136; or c. said nucleotide sequence encodes both the light chain and the heavy chain of said anti-IGF-IR antibody, or of said antigen binding fragment of said anti-IGF1R antibody, and wherein the light chain variable region of said anti-IGF-1R antibody or antigen binding fragment is at least 90% identical to SEQ ID NO:32 and the heavy chain variable region of said anti-IGF-1R antibody or antigen binding fragment is at least 90% identical to SEQ ID NO:136.