Patent ID: 8119821

Claim:
A process of preparing a compound having structural Formula (a): comprising: mixing a compound having structural Formula (b): with a compound having structural Formula (c): in the presence of an organic amine at a temperature of about 0° C. or below to obtain a reaction mixture; maintaining the reaction mixture at a temperature of about 0° C. or below for about 30 to about 90 minutes; concentrating the reaction mixture to obtain a slurry; and filtering the slurry to obtain the compound having structural Formula (a) as solid particles; wherein: R 1 is hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; R 2 is hydrogen, alkyl, heteroalkyl, alkenyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or alternatively, R 1 and R 2 , together with the atoms to which they are attached, form a carbocyclic ring or heterocyclic ring; X is CN or —C(O)R 3 ; R 3 is alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, OR 4 , or N(R 4) 2 ; and each R 4 is independently hydrogen, alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl.