Patent ID: 8592596

Claim:
A process for preparing a purified form of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine comprising: (a) combining 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine-1-carboxylic acid t-butyl ester with 1.25M HCl in ethanol to form a slurry; (b) adding ethyl acetate to the slurry to form a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]-piperidine; and (c) isolating the crystalline hydrochloride salt to yield a form of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine having >99% purity, characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2θ values of 4.44+0.20, 10.22+0.20, 17.16+0.20, and 21.78+0.20.