Patent ID: 6903112

Claim:
A compound of formula I wherein Q is SO 2 ; either W is N or CR 6 and X is N, or W is CR 6 and X is N or CR 7 ; Y is NR 8 or CR 9 R 10 ; n is an integer of 1; Z is NR 11 or CR 12 R 13 with the proviso that when W is CR 6 then Z must be CR 12 R 13 and with the further provisos that when Y is NR 8 then Z must be CR 12 R 13 and at least one of Y and Z must be NR 8 or NR 11 ; R 1 , R 2 and R 7 , are each independently H, halogen, CN, OCO 2 R 14 , CO 2 R 15 , CONR 29 R 30 , CNR 16 NR 17 R 18 , SO m R 19 , NR 20 R 21 , OR 22 , COR 23 or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 3 , R 4 , R 9 , R 10 , R 12 and R 13 are each independently H or an optionally substituted C 1 -C 6 alkyl group; R 5 is an optionally substituted C 1 -C 6 alkyl, aryl or heteroaryl group; m is 0 or an integer of 1 or 2; R 6 is H, halogen, or an optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl or heteroaryl group; R 8 and R 11 are each independently H, CNR 26 NR 27 R 28 or a C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, cycloheteralkyl, aryl or heteroaryl group; R 14 , R 15 , R 22 and R 23 are each independently H or an optionally substituted C 1- C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group; R 16 , R 17 , R 18 , R 20 , R 21 , R 26 , R 27 , R 28 , R 29 and R 30 are each independently H or C 1 -C 4 alkyl; R 19 , is an optionally substituted C 1 -C 4 alkyl, aryl or heteroaryl group; R 24 and R 25 are each independently H or an optionally substituted C 1 -C 6 alkyl, aryl or heteroaryl group; and represents a single bond or a double bond; or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.