Patent ID: 7674791

Claim:
A compound of the following formula: or a pharmaceutically acceptable salt or N-oxide thereof; wherein A is aryl or furanyl; R 2 and R 3 are hydrogen; X 1 is alkynylene; X 2 , and X 3 are a bond; L is a linker of the following formula: wherein: R′ is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, sulfoxy, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; provided that two adjacent R′ groups can join together to form a 4- to 8-membered optionally substituted cyclic moiety; each of p, q, and m, independently, is 0-3; Y is a bond; and R 1 is hydrogen.