Patent ID: 8709379

Claim:
A lipid nanoparticle composition comprising a neutral retinoid in a phospholipid component, wherein (a) the nanoparticles have diameters of less than or equal to about 1000 nm; (b) the retinoid is integrated within the phospholipid component to a final retinoid concentration of between about 4 and about 75 mg/ml; (c) the phospholipid component is: (i) a plant lecithin acceptable for use in mammals in vivo; (ii) phospholipids of said lecithin of (i); (iii) cholic acid or a salt thereof and one or more synthetic, chemically-defined phospholipids having two fatty acid chains; or (iv) one or more synthetic chemically-defined phospholipids having two fatty acid chains; and (d) the nanoparticles have a surface charge characterized by a zeta potential of between about −50 millivolts to about +10 millivolts.