Patent ID: 7423010

Claim:
A composition of matter comprising a prodrug of a biologically-active compound, a nonporous microparticle, and an organic coating material, wherein the prodrug comprises a biologically active compound, a polar lipid moiety comprised of one or a plurality of polar lipid molecules and a specific linker moiety, wherein the specific linker moiety is covalently linked to both the biologically active compound and the polar lipid moiety, wherein the nonporous microparticle is first coated with the prodrug and said coated microparticle is further coated with the organic coating material, and wherein the organic coating material is nonspecifically degraded inside a phagocytic mammalian cell infected with a microorganism to allow release of the prodrug within the infected cell, and wherein the specific linker moiety is specifically cleaved in a phagocytic mammalian cell infected with a microorganism and the prodrug is specifically activated thereby, wherein the polar lipid is selected from the group consisting of acyl carnitine, acylated carnitine, sphingosine, ceramide, phosphatidyl choline, phosphatidyl glycerol, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl serine, cardiolipin and phosphatidic acid.