Patent ID: 8222202

Claim:
A method of treating a condition selected from: hypertensive gastropathy bleeding; prolonged and severe hypotension; intradialytic hypotension; vasodilatory shock induced by cardio-pulmonary bypass; milrinone-induced vasodilatory shock in congestive heart failure; anaphylactic shock; cardiovascular instability induced by brain death; acute respiratory distress syndrome; acute lung injury; shock induced by metformin intoxication, mitochondrial disease, cyanide poisoning, or by vascular leak syndrome induced by interleukin-2 or another cytokine, denileukin diftitox or another immunotoxin, or ovarian hyperstimulation syndrome; hypertension induced by end-stage renal disease; irritable bowel disease; reperfusion injury; infant respiratory distress syndrome; severe acute respiratory syndrome; ascites; vasodepressor syncope; toxic shock syndrome; and idiopathic systemic capillary leak syndrome (Clarkson's disease); wherein the method comprises administering to an animal patient in need of such treatment a therapeutically effective amount of a compound having the formula (I): wherein: Ar is an aryl group selected from aromatic carbocyclic ring systems, five- or six-membered heteroaromatic ring systems and bicyclic heteroaromatic ring systems; m is selected from 1, 2 and 3; n is selected from 0, 1, 2, 3 and 4; p is selected from 2, 3 and 4; R 1 , R 2 and R 3 are independently selected from H, OH, alkyl, O-alkyl and OC(O)-alkyl; alkyl is selected from C 1-6 straight and C 4-8 branched chain alkyl and optionally has at least one hydroxyl substituent; and when n=0, R 1 and R 2 optionally together form a nitrogen containing ring structure comprising from 2 to 5 carbon atoms; with the proviso that when Ar is phenyl, m=2, n=0, R 1 =R 2 =H, and p is 3 or 4, R 3 is not H; or a pharmaceutically acceptable salt thereof or a solvate thereof.