Patent ID: 8350028

Claim:
A compound of formula (I) wherein R 1 is —C(O)-cycloalkyl, —C(O)-alkyl, —C(O)-alkylene-cycloalkyl, —C(O)-alkylene-heterocycloalkyl, —C(O)-heterocycloalkyl, —C(O)—NR a R b , —S(O) 2 -heterocycloalkyl, —S(O) 2 —NR c R d , alkyl, haloalkyl, cyanoalkyl, hydroxyalkyl, -alkylene-cycloalkyl, -alkylene-heterocycloalkyl, -alkylene-NR e R f , -alkylene-O-alkyl, or -alkylene-S(O) x -alkyl; x is 0, 1 or 2; R a , R b , R c , R d , R e , and R f are each independently selected from H, alkyl, cycloalkyl, and heterocycloalkyl; heterocycloalkyl is unsubstituted or substituted with one or more substituents independently selected from alkyl, hydroxy, hydroxyalkyl, benzyl, oxo, —C(O)Oalkyl, cycloalkyl, alkylene-O-alkyl, —C(O)haloalkyl, —C(O)-alkylene-O-alkyl, cyanoalkyl, alkylene-S(O) x -alkyl, -alkylene-C(O)N(alkyl) 2 , halo, haloalkyl and alkoxy; R 2 is —Ar 1 , —CH 2 —Ar 1 , or —CH 2 CH 2 O—Ar 1 ; Ar 1 is phenyl or 5- or 6-membered heteroaryl, each unsubstituted or substituted with one or more alkyl, cycloalkyl, alkoxy, haloalkoxy, haloalkyl, halo, OH, or CN, or with two substituents in the ortho-position that form a bridge anellated to the aromatic ring, wherein the bridge is selected from —O—CH 2 CH 2 O—, —OCHCH 3 CH 2 —, or —OC(CH 3 ) 2 CH 2 —, and wherein phenyl is not substituted with halo in para-position; or a pharmaceutically acceptable salt thereof.