Patent ID: 8716217

Claim:
Polyamino acid, or a pharmaceutically acceptable salt thereof, comprising glutamic residues, wherein at least one glutamic residue carries a pendant cationic group which, if it can be deprotonated, exhibits a pKa equal to or greater than 7, said pendant cationic groups being identical to or different from one another, and wherein at least one glutamic residue carries a pendant nonionizable hydrophobic group (GH), the pendant hydrophobic groups (GH) being identical to or different from one another, said hydrophobic groups (GH) being selected from the group consisting of: linear or branched C 8 to C 30 alkyls; linear or branched C 8 to C 30 alkyl comprising at least one unsaturation or at least one heteroatom; C 8 to C 30 alkylaryls or arylalkyls; C 8 to C 30 alkylaryls or arylalkyls comprising at least one unsaturation or at least one heteroatom; C 8 to C 30 (poly)cyclic compounds; or C 8 to C 30 (poly)cyclic compounds comprising at least one unsaturation or at least one heteroatom; said pendant cationic groups: having the formula of: in which: X is an O or NH, Y is independently an H or CH 3 , Z − is selected from the group consisting of: a chloride, a sulfate, a phosphate and an acetate, L comprises a linear (C 2 to C 6 ) alkylene, a linear (C 2 to C 6 ) alkylene substituted by a functional carboxyl group, or being selected from the group consisting of: where Ra is a hydroxyl, alkoxy or alkylamino group and Z − is selected from the group consisting of: a chloride, a sulfate, a phosphate and an acetate, —NH—(CH 2 ) 4 —NH—C(═NH)—NH 3 + , Z − , where Z − is selected from the group consisting of: a chloride, a sulfate, a phosphate and an acetate.