Patent ID: 7074765

Claim:
A compound consisting of an amino acid sequence of formula A 1 -A 2 -A 3 -A 4 -A 5 wherein A 1 is selected from the group consisting of D-arginine (r) and L-arginine (R); A 2 is selected from the group consisting of (2S, 3aS, 7aS)-octahydroindole-2-carboxlic acid (Oic), Hydroxyproline (Hyp), Î±-(2-indanyl)glycine (Idg), proline (P), 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic), Pentafluorophenylalanine (F5F) and Î²-(2-thienyl)-L-alanine (Thi); A 3 is selected from the group consisting of Oic, Hyp, Idg, P, Tic, F5F, and Thi; A 4 is glycine (G); A 5 is selected from the group consisting of L-phenylalanine (F), Oic, Hyp, Idg, Tic, F5F and Thi; wherein at least one of A 1 -A 5 is not a naturally occurring amino acid residue and wherein said compound is an inhibitor of at least one thrombin-mediated activity.