Patent ID: 8329750

Claim:
A method for improving quality of sleep at night in a subject experiencing vasomotor symptoms, comprising: administering to a subject experiencing vasomotor symptoms a twice-daily dose of gabapentin in a dosage form comprising a hydrophilic polymer, wherein after administration the dosage form swells to a size that is retained in the stomach of the subject in a fed mode, and wherein the administering comprises administering a first dose of 600 mg with a morning meal and a second dose of 1200 mg with an evening meal; whereby the dose of gabapentin improves the quality of sleep at night in the subject, as measured by the Pittsburgh Quality Sleep Index, relative to a subject experiencing vasomotor symptoms untreated with the dose of gabapentin; and wherein the subject experiences minimal daytime somnolence or reduced daytime somnolence relative to somnolence experienced with an immediate release dose of gabapentin.