Patent ID: 8775090

Claim:
A method of identifying a compound that binds a human IgG or a human IgG Fc region, comprising (a) computationally screening a candidate compound for an ability to bind the human IgG or the human IgG Fc region using a three-dimensional structural representation of a human IgG Fc variant comprising SEQ ID NO:7 or SEQ ID NO:11, and having amino acid residue mutations M252Y, S254T and T256E, as numbered by the EU index as set forth in Kabat, wherein the three-dimensional structural representation of a human IgG Fc variant is generated from the coordinates provided in Table V; (b) contacting the compound with a human IgG or human IgG Fc region; and (c) determining the binding affinity of the compound for human IgG or human IgG Fc region.