Patent ID: 7807135

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt or prodrug thereof, wherein: R 1 is NR a R b , wherein R a and R b are independently hydrogen or C 1-4 alkyl; R 1′ is hydrogen; R 2 is selected from the group consisting of i. hydroxyl, C 1-4 Alkoxy, (C 1 -C 4 )-alkyloxoAlk(C 1 -C 4 )oxy, (C 1 -C 4 )-alkyloxo(C 1 -C 4 )-alkyloxo(C 1 -C 4 )alkoxy, (C 1 -C 4 )-alkyloxo(C 1 -C 4 )-alkyloxo(C 1 -C 4 )-alkyloxo(C 1 -C 4 )alkoxy, carboxy(C 1 -C 4 )Alkyl, halo(C 1 -C 4 )alkoxy, halo(C 1 -C 4 )-alkyloxo (C 1 -C 4 )alkoxy, halo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxo(C 1 -C 4 )-alkyloxy, halo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxy, halo(C 1 -C 4 )alkyl, NR 6 R 6′ , phenyl(C 1 -C 4 )alkyl, 18 F(C 1 -C 4 )alkoxy, 18 F(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkoxy, 18 F(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxy, 18 F(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxo(C 1 -C 4 )alkyloxy, 18 F(C 1 -C 4 )alkyl, wherein R 6 and R 6′ are independently selected from the group consisting of hydrogen, hydroxy(C 1 -C 4 )alkyl and C 1 -C 4 alkyl; where q is an integer from one to 10; Z is selected from the group consisting of 18 F, 18 F substituted benzoyloxy, 18 F substituted (C 1-4 )alkoxy, 18 F substituted benzyloxy, optionally 18 F-phenoxy, 18 F substituted phenyl(C 1-4 )alkyl, 18 F substituted aryloxy, and a 18 F substituted C 6-10 aryl, optionally 18 F-phenyl; and R 30 , R 31 , R 32 and R 33 are in each instance independently selected from the group consisting of hydrogen, hydroxy, C 1-4 alkoxy, C 1-4 alkyl and hydroxy(C 1-4 )alkyl; where Z, R 30 , R 31 , R 32 and R 33 are as described above; where Y is selected from the group consisting of 18 F, 18 F substituted benzoyloxy, 18 F substituted phenyl(C 1-4 )alkyl, 18 F substituted aryloxy optionally 18 F-phenoxy and 18 F substituted C 6-10 aryl, optionally 18 F-phenyl; U is selected from the group consisting of hydrogen, hydroxy, 18 F, 18 F substituted benzoyloxy, 18 F substituted phenyl(C 1-4 )alkyl, 18 F substituted aryloxy, optionally 18 F-phenoxy and 18 F substituted C 6-10 aryl, optionally 18 F-phenyl; and R 34 , R 35 , R 36 , R 37 , R 38 , R 39 and R 40 are in each instance independently selected from the group consisting of hydrogen, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, and hydroxy(C 1-4 )alkyl; and R 7 and R 8 are in each instance independently selected from the group consisting of halogen, hydrogen, hydroxy, amino, methylamino, dimethylamino, C 1-4 alkoxy, C 1-4 alkyl, and hydroxy(C 1-4 )alkyl, wherein at least one of R 7 and R 8 is halogen.