Patent ID: 7528173

Claim:
A compound of formula I wherein: R 1 is hydrogen; R 2 is —P(O)(OR 5 )—R 7 —N(R 5 )—S(O) 2 —R 9 ; R 3 is tetrazole, —C(O)OR 6 , or —C(O)O—R 7 —OC(O)R 5 ; R 4 is aryl optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, nitro, cyano, —N(R 6 ) 2 , —R 7 —N(R 6 ) 2 , —N(R 6 )—C(O)OR 8 , —R 7 —N(R 6 )—C(O)OR 8 , —N(R 6 )—C(O)R 6 , —R 7 —N(R 6 )—C(O)—R 6 , —C(O)—N(R 6 ) 2 , —C(O)—R 7 —N(R 6 ) 2 , —N(R 5 )—C(NR 5 )—N(R 5 ) 2 , —N(R 5 )—C(O)—N(R 6 ) 2 and —N(R 5 )—C(O)—R 7 —N(R 6 2 ); each R 5 is independently hydrogen, alkyl or aralkyl; each R 6 is independently hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl or aralkenyl; each R 7 is independently cycloalkylene (optionally substituted by alkyl), a straight or branched alkylene chain (optionally substituted by hydroxy, mercapto, alkylthio, aryl, cycloalkyl, —N(R 6 ) 2 , —C(O)OR 6 , or —C(O)N(R 6 ) 2 ), or a straight or branched alkenylene chain (optionally substituted by hydroxy, mercapto, alkylthio, aryl, cycloalkyl, —N(R 6 ) 2 , —C(O)OR 6 , or —C(O)N(R 6 ) 2 ); each R 8 is independently alkyl, alkenyl, aryl, aralkyl or aralkenyl; and R 9 is —R 7 N(R 6 )C(O)OR 8 , haloalkyl, alkyl (optionally substituted by hydroxy, alkoxy, aralkoxy, haloalkoxy, cyano, nitro, —N(R 6 ) 2 , —C(O)OR 6 , —C(O)N(R 6 ) 2 or —N(R 6 )C(O)R 6 ), alkenyl (optionally substituted by hydroxy, alkoxy, haloalkoxy, cyano, nitro, —N(R 6 ) 2 , —C(O)OR 6 , —C(O)N(R 6 ) 2 or —N(R 6 )C(O)R 6 ), aryl (optionally substituted by alkyl, aryl, aralkyl, hydroxy, alkoxy, cyano, nitro, halo, haloalkoxy, —N(R 6 ) 2 , —C(O)OR 6 , —C(O)N(R 6 ) 2 or —N(R 6 )C(O)R 6 ) 2 , aralkyl (wherein the aryl group is optionally substituted by alkyl, aryl, aralkyl, hydroxy, alkoxy, cyano, nitro, halo, haloalkoxy, —N(R 6 ) 2 , —C(O)OR 6 , —C(O)N(R 6 ) 2 or —N(R 6 )C(O)R 6 ), aralkenyl (wherein the aryl group is optionally substituted by alkyl, aryl, aralkyl, hydroxy, alkoxy, cyano, nitro, halo, haloalkoxy, —N(R 6 ) 2 , —C(O)OR 6 , —C(O)N(R 6 ) 2 or —N(R 6 )C(O)R 6 ), or N-heterocyclyl (optionally substituted by alkyl, aryl, aralkyl, hydroxy, alkoxy, cyano, nitro, halo, haloalkoxy, —N(R 6 ) 2 , —C(O)OR 6 , —C(O)N(R 6 ) 2 or —N(R 6 )C(O)R 6 ), as a single stereoisomer, a mixture of stereoisomers, or as a racemic mixture of stereoisomers; or a pharmaceutically acceptable salt thereof.