Patent ID: 7521444

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is a [4.4.0], [4.3.0] or [3.3.0] bicyclic diamine attached to the carbonyl through one nitrogen, and is substituted with 0-2 R 8 substituents; R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 )(R 10 )NSO 2 , or (R 11 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, (cycloalkyl)carbonyl, alkoxycarbonyl, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, (R 12 )carbonyl, benzyl, or benzyloxycarbonyl; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N—(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; and R 12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N—(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; or a pharmaceutically acceptable salt thereof.