Patent ID: 6919423

Claim:
A racemate, diastereoisomer, or optical isomer of a compound of formula (I): wherein B is (C 1-10 )alkyl, (C 3-7 )cycloalkyl, or (C 1-4 )alkyl-(C 3-7 )cycloalkyl, a) wherein said cycloalkyl and alkyl-cycloalkyl may be mono-, di- or tri-substituted with (C 1-3 )alkyl; and b) wherein said alkyl, cycloalkyl, and alkyl-cycloalkyl may be mono- or di-substituted with substituents selected from hydroxy and O—(C 1-4 )alkyl; and c) wherein each of said alkyl groups may be mono-, di- or tri-substituted by halogen; and d) wherein in each of said cycloalkyl groups being 5-, 6- or 7-membered, one or two —CH 2 -groups not being directly linked to each other may be replaced by —O— such that the O-atom is linked to the group X via at least two C-atoms; X is O or NH; R 3 is (C 2-8 )alkyl, (C 3-7 )cycloalkyl, or (C 1-3 )alkyl-(C 3-7 )cycloalkyl, wherein each of said alkyl and cycloalkyl groups may be mono-, di- or tri-substituted with (C 1-4 )alkyl; R 21 is H, halogen, —OH, (C 1-6 )alkyl, (C 3-6 )cycloalkyl, —(C 1-4 )alkyl-(C 3-6 )cycloalkyl, (C 1-6 )alkoxy, —O—(C 3-6 )cycloalkyl, —O—(C 1-4 )alkyl-(C 3-6 )cycloalkyl or —N(R 24 ) 2 , wherein each R 24 is independently: H, (C 1-6 )alkyl, —(C 3-6 )cycloalkyl, or —(C 1-4 )alkyl-(C 3-6 )cycloalkyl; R 22 is NR N2 COOR 0 or —NR N2 CONR N3 R N1 , wherein R 0 is selected from (C 1-8 )alkyl, (C 3-7 )cycloalkyl, and (C 1-4 )alkyl-(C 3-7 )cycloalkyl, wherein said cycloalkyl and alkyl-cycloalkyl may be mono-, di- or tri-substituted with (C 1-3 )alkyl; R N1 is H or R 0 as defined above; and R N2 and R N3 are independently selected from H and methyl; R 1 is ethyl or vinyl; R c is hydroxy or NHSO 2 R S wherein R S is (C 1-6 )alkyl, (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl, phenyl, naphthyl, pyridinyl, (C 1-4 )alkyl-phenyl, (C 1-4 )alkyl-naphthyl or (C 1-4 )alkyl-pyridinyl; each of which optionally being mono-, di- or tri-substituted with substituents selected from halogen, hydroxy, cyano, (C 1-4 )alkyl, O—(C 1-6 )alkyl, —CO—NH 2 , —CO—N H((C 1-4 )alkyl), —CO—N((C 1-4 )alkyl) 2 , —NH 2 , —NH((C 1-4 )alkyl), —N((C 1-4 )alkyl) 2 , wherein (C 1-4 )alkyl and O—(C 1-6 )alkyl are optionally mono-, di- or trisubstituted with halogen; and each of which optionally being monosubstituted with nitro; or a pharmaceutically acceptable salt or ester thereof.