Patent ID: 7547692

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein (a) A is H, OH, O—(C 1-6 alkyl), O—(C 1-4 alkaryl), O—(C 6-12 aryl), O—(C 1-9 heteroaryl), or O—(C 1-4 alkheteroaryl); W is O, S, or NR 1 , wherein R 1 is H, C 1-6 alkyl, C 1-4 alkaryl, or C 1-4 alkheteroaryl; X is H or COR 2 , wherein R 2 is C 1-6 alkyl, which can be substituted with 1-5 OH groups, O—(C 3-7 alkyl), which can be substituted with 1-4 OH groups, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, wherein each alkyl carbon is bonded to no more than one oxygen atom; Y is H, Hal, or OR Y3 , wherein R Y3 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl; Z is H, Hal, or OR Z3 wherein R Z3 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl; and R 4 has the formula: wherein R 5 is H, C 1-6 alkyl, C 1-4 alkaryl, C 1-4 alkheteroaryl, COR 10 , CO 2 R 11 , CONR 10 R 11 CSR 10 , COSR 11 , CSOR 10 , CSNR 10 R 11 , SO 2 R 11 , or SO 2 NR 10 R 11 , wherein R 10 is H, C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, R 11 is H, C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, or R 10 and R 11 together form a C 2-6 linkage, optionally containing a non-vicinal O; R 6 is H, C 1-6 alkyl, C 1-4 alkaryl, C 1-4 alkheteroaryl; R 7 is H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 2-9 heterocyclyl, C 1-4 alkaryl, C 1-4 alkheteroaryl, OR 12 , or NR 12 R 13 , wherein R 12 is H, C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, R 13 is C 1-6 alkyl, C 6-12 aryl, C 1-4 alkaryl, C 1-9 heteroaryl, or C 1-4 alkheteroaryl, or R 12 and R 13 together from a C 2-6 linkage, optionally containing a non-vicinal O; T is O, S, NR 5 , or a bond; each of R 8 and R 9 is, independently H, C 1-6 alkyl, C 6-12 aryl, C 1-9 heteroaryl, C 2-9 heterocyclyl, C 1-4 alkaryl, or C 1-4 alkheteroaryl, or R 8 and R 5 together form a 3-8-membered ring, with the ring optionally containing a non-vicinal oxygen; and each of r and s is, independently, 1 or 2, wherein said C 1-9 heteroaryl is selected from the group consisting of furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, tetrazolyl, oxadiazolyl, oxatriazolyl, pyridyl, pyridazyl, pyrimidyl, pyrazyl, triazyl, benzofuranyl, isobenzofuranyl, benzothienyl, indole, indazolyl, indolizinyl, benzisoxazolyl, quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, naphtyridinyl, phthalazinyl, phenanthrolinyl, purinyl, and carbazolyl, and wherein, when W is O or NR 1 , T is a bond, R 8 and R 9 are H, and X is COR 2 , R 4 is not and when W is O, and X is COR 2 , R 4 is not