Patent ID: 8518948

Claim:
A compound of Formula (I): or a pharmaceutically acceptable salt, polymorph, tautomers or stereoisomers thereof wherein: R a is H or methyl; R 1 is selected from the group consisting of: carbocyclic or —C 1-6 alkyl-carbocyclic, wherein the carbocyclic group is cyclohexyl or cyclopentyl; heterocyclic or —C 1-6 alkyl-heterocyclic group, wherein the heterocyclic group is piperidine, piperazine, morpholine or pyrrolidine; aryl or —C 1-6 alkyl-aryl; heteroaryl or —C 1-6 alkyl-heteroaryl, wherein the heteroaryl group is pyridine, thiazole or thiophene; wherein any of the aforesaid carbocyclic, heterocyclic, aryl or heteroaryl groups may optionally be substituted by one or more groups independently selected from: halo, OH, NH 2 and, for carbocyclic and heterocyclic groups, ═O; or C 1-4 alkyl, —O(C 1-4 alkyl), —NH(C 1-4 alkyl), —NHC(O)(C 1-4 alkyl), —S(C 1-4 alkyl), —SO(C 1-4 alkyl), —SO 2 (C 1-4 alkyl) or —SO 2 NH(C 1-4 alkyl) any of which may be further substituted with halo or OH; or R 3 , —C 1-4 alkyl-R 3 , OR 3 , NHR 3 , —NHC 1-4 alkyl-R 3 , —OC 1-4 alkyl-R 3 , SR 3 , SOR 3 or SO 2 R 3 ; wherein R 3 is an aryl, heteroaryl, carbocyclic or heterocyclic group any of which may be substituted with one or more halo, C 1-4 alkyl, —O(C 1-4 alkyl), NH 2 , —NH(C 1-4 alkyl), —C(O)(C 1-4 alkyl), —NHC(O)(C 1-4 alkyl) groups, any of which alkyl groups may be substituted with halo or OH; each R 2 is independently halo, OH, NH 2 ; or C 1-4 alkyl, —O(C 1-4 alkyl), —NH(C 1-4 alkyl), —C(O)(C 1-4 alkyl), any of which may be further substituted with halo or OH; or R 4 , —C 1-4 alkyl-R 4 , OR 4 , NHR 4 , —NHC 1-4 alkyl-R 4 , —OC 1-4 alkyl-R 4 , SR 4 , SOR 4 or SO 2 R 4 ; wherein R 4 is an aryl, heteroaryl, carbocyclic or heterocyclic group any of which may be further substituted with one or more halo, OH, C 1-4 alkyl, —O(C 1-4 alkyl), NH 2 , —NH(C 1-4 alkyl), —C(O)(C 1-4 alkyl), —NHC(O)(C 1-4 alkyl) groups, any of which alkyl groups may be substituted with halo or OH; and x is 0-4.