Patent ID: 6881728

Claim:
A steroid compound satisfying the structural formula: wherein R 1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C 1-6 )alkyl, (C 1-6 )acyl; R 2 is hydrogen, (C 1-6 )alkyl, or halogen; R 3 is hydrogen, (C 1-6 )alkyl, (C 2-6 )alkenyl, or (C 2-6 )alkynyl; R 4 is hydrogen, halogen, or cyano; or R 4 is (C 1-6 )alkyl, (C 2-6 )alkenyl or (C 2-6 )alkynyl, each optionally substituted by hydroxy, (C 1-4 )alkoxy, oxo, halogen, or cyano; R 5 is hydrogen, or (C 1-6 )alkyl; R 6 is hydrogen, (C 1-6 )alkoxy, or halogen; or R 6 is (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 2-6 )alkynyl, a (C 1-6 )alkylidene group, or a (C 2-6 )alkenylidene group, each optionally substituted by hydroxy, (C 1-4 )alkoxy, oxo, halogen, or cyano; R 7 is hydrogen, or (C 1-6 )alkyl; R 8 is (C 1-4 )alkyl; R 9 is hydrogen, halogen or cyano; or R 9 is (C 1-6 )alkyl, (C 2-6 )alkenyl, or (C 2-6 )alkynyl, each optionally substituted by hydroxy, (C 1-4 )alkoxy, oxo, halogen, or cyano; R 10 is hydrogen, (C 1-6 )alkoxy, halogen, or cyano; or R 10 is (C 1-6 )alkyl, (C 2-6 )alkenyl or (C 2-6 )alkynyl, each optionally substituted by hydroxy, (C 1-4 )alkoxy, oxo, halogen, or cyano; or R 10 together with R 11 and the carbon atoms at which they are placed form a cyclopropane ring; R 11 is hydrogen, (C 1-6 )alkoxy, halogen, or cyano; or R 11 is (C 1-6 )alkyl, (C 2-6 )alkenyl or (C 2-6 )alkynyl, each optionally substituted by hydroxy, (C 1-4 )alkoxy, oxo, halogen, or cyano; or R 11 together with R 10 and the carbon atoms at which they are placed form a cyclopropane ring; R 12 is hydrogen, hydroxy, halogen, or cyano; or R 12 is (C 1-6 )alkyl, (C 2-6 )akenyl, (C 2-6 )alknyl, each optionally substituted by hydroxy, (C 1-4 )alkoxy, oxo, halogen, or cyano; R 13 and R 14 are independently hydrogen, cyano, or phenyl, the latter optionally substituted by hydroxy, (C 1-4 )alkoxy, (C 1-4 )alkyl or halogen; or R 13 and R 14 are independently (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 3-6 )cycloalkyl, (C 5-6 )cycloalkenyl or (C 2-6 ) alkynyl, each optionally substituted by hydroxy, (C 1-4 )alkoxy, phenyl, oxo, halogen, or cyano; or R 13 and R 14 together with the carbon atom at which they are placed form a (C 3-6 )cycloalkene ring or a (C 5-6 )cycloalkene ring; R 15 is hydrogen, SO 3 H, (C 1-6 )alkyl, (C 1-15 )acyl; and the dotted lines indicate optional bonds, with the proviso that the compound is not any one of 20-hydroxy-14β,17α-19-norpregn-4en-3one, (3β,5α,14β,17α)-pregna-3,20-diol, (3β,14β,17α)-pregna-5,9(11)dien-3,20-diol, (14β,17α)-20hydroxy-19-norpregn-4-en-3-one, and 5α,14β,17α-pregnane-3β,17,20-triol 3,20-diacetate.