Patent ID: 7176222

Claim:
A method for the synthesis of an enantiomerically pure compound of Formula I: where: R 1.3 is chosen from hydrogen, halo, optionally substituted heteroaryl, and nitro; R 2 is chosen from optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, and optionally substituted heterocyclyl; R 3 is chosen from optionally substituted acyl, optionally substituted alkoxycarbonyl, amidino, and sulfonyl; and n is 1 or 2, wherein the method comprises at least one of the steps: A) contacting a base with an enantiomerically pure compound of Formula 101: B) reacting the product of step A with a compound of Formula 102: and C) converting the product of step B to the compound of Formula I.