Patent ID: 8084585

Claim:
An isolated monoclonal antibody or an antigen binding fragment thereof which binds to an extracellular domain of human ILT7, wherein the monoclonal antibody or antibody fragment comprises the amino acid sequences according to any of the following i) to iii) as CDR1, CDR2, and CDR3 in the heavy chain variable region and the light chain variable region: CDR1 of a heavy chain variable region: SDYAWN (SEQ ID NO: 58); CDR2 of a heavy chain variable region: YISYSGSTSYNPSLKSR (SEQ ID NO: 59); and CDR3 of a heavy chain variable region: SPPYYAMDY (SEQ ID NO: 60); CDR1 of light chain variable region: KASQDVGTAVA (SEQ ID NO: 61): CDR2 of a light chain variable region: WASTRIAT (SEQ ID NO: 62); and CDR3 of a light chain variable region: QQYSSYPLT (SEQ ID NO: 63); ii) CDR1 of a heavy chain variable region: SYWIH (SEQ ID NO: 64); CDR2 of a heavy chain variable region: RIYPGTGSTYNNEKFKG (SEQ ID NO: 65); and CDR3 of a heavy chain variable region: YPTYDWYFDV (SEQ ID NO: 66): CDR1 of a light chain variable region: RASQSISNYLH (SEQ ID NO: 67); CDR2 of a light chain variable region: YASQSIS (SEQ ID NO: 68); and CDR3 of a light chain variable region: QQSNSWPLT (SEQ ID NO: 69); iii) CDR1 of a heavy chain variable region: SDYAWN (SEQ ID NO: 70); CDR2 of a heavy chain variable region: YISYSGSTSYNPSLKSR (SEQ ID NO: 71); CDR3 of a heavy chain variable region: ALPLPWFAY (SEQ ID NO: 72); CDR1 of a light chain able region: KASQDVGTAVA (SEQ ID NO: 73); CDR2 of a light chain variable region: WASTRHT (SEQ ID NO: 74); and CDR3 of a light chain variable region: QQYSSYPYT (SEQ ID NO: 75).