Patent ID: 8329709

Claim:
A compound of Formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: R 1 and R 1a are independently selected from hydrogen, methyl, ethyl, —CH═CH 2 , —CH 2 OH, CF 3 , CHF 2 or CH 2 F; R 2 is selected from hydrogen, OH, OCH 3 or F; R 2a is selected from hydrogen, methyl or F, or R 2 and R 2a are oxo; L is selected from: wherein the single wavy line is where L attaches to A and the double wavy line is where L attaches to the pyrimidine; A is: X is a direct bond from L to Y, CH 2 , O, C═O, NH or C(═O)NH; Y is CH or N; Z is absent, CH 2 or O, wherein L, X, Y, Z and b are selected so that any nitrogen is not bonded directly to another nitrogen; G is phenyl optionally substituted with one to four R a groups or a 5-6 membered heteroaryl optionally substituted by a halogen; R 3 and R 4 are independently selected from hydrogen or methyl; R 5 and R 6 are independently selected from hydrogen or C 1 -C 4 alkyl; a is 0 or 1; b is 0, 1 or 2; and each R a is independently halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, —O—(C 1 -C 6 -alkyl), CF 3 , —OCF 3 , S(C 1 -C 6 -alkyl), CN, —OCH 2 -phenyl, NH 2 , —NO 2 , —NH—(C 1 -C 6 -alkyl), —N—(C 1 —C 6 -alkyl) 2 , piperidine, pyrrolidine, CH 2 F, CHF 2 , —OCH 2 F, —OCHF 2 , —OH, —SO 2 (C 1 -C 6 -alkyl), C(O)NH 2 , C(O)NH(C 1 -C 6 -alkyl), and C(O)N(C 1 -C 6 -alkyl) 2 ; or b is 1, R 3 is hydrogen and R 4 and R 5 together with the atoms to which they are attached form an optionally substituted 5-6 membered heterocyclic ring having one ring nitrogen atom, and R 6 is selected from the group consisting of H or C 1 -C 4 alkyl optionally substituted with OH or O(C 1 -C 3 alkyl), such that A has the structure: R c and R d are independently selected from hydrogen and methyl; and c is 1 or 2; or b is 1, Z is CH 2 and R 5 and Y together with the atoms to which they are attached form an optionally substituted 6 membered heterocyclic ring having one ring nitrogen atom, and R 6 is selected from the group consisting of hydrogen or C 1 -C 4 alkyl optionally substituted with OH or O(C 1 -C 3 alkyl), such that A has the structure: