Patent ID: 7504389

Claim:
A compound of Formula IIa: wherein R a and R b are independently halogen; R 26 , R 27 , R 29 and R 30 are each independently H, halo, —OH, —NO 2 , —CN, —CF 3 , —CHF 2 , —CH 2 CH 3 , —CH 2 CF 3 , —CF 2 CF 3 , —CH 2 Cl, —CH 2 OH, —CH 2 CH 2 OH, —CH 2 NH 2 , —CH 2 CH 2 NH 2 , —CH 2 SO 2 CH 3 , —OR 23 , —C(O)R 23 , —C(O)OR 23 , —C(O)N(R 23 )(R 24 ), —OC(O)R 23 , —OC(O)R 23 , —OC(O)N(R 23 )(R 24 ), —N(R 23 )(R 24 ), —S(O) 2 N(R 23 )(R 24 ), —NR 23 C(O)R 24 , —NR 23 C(O)OR 24 , —NR 23 SOOR 24 , —NR 23 C(O)N(R 24 )(R 25 ), —NR 23 SO 2 R 24 , —NR 23 SO 2 N(R 24 )(R 25 ) or optionally substituted C 1-6 alkyl, C 1-6 alkoxy, or aryl; where R 23 , R 24 and R 25 are each independently H, C 1-4 alkyl or C 3-8 cycloalkyl, or aryl; R 31 and R 32 are each independently H, alkyl or C 5-6 aryl; R 28 is —(CH 2 ) n —CH(R 34 )(R 35 ) or R 28 taken together with either R 27 or R 29 form an optionally substituted ring comprising 3 to 8 carbon atoms; R 34 is —N(R 37 )(R 38 ); R 35 is —C(O)R 34 , —C(O)OR 39 or —N(NH 2 )C(O)NH(CH 2 ) n Ph; R 37 and R 38 are each independently H, —C(O)OR 39 , —C(O)cycloalkyl-Ph, —S(O) 2 R 39 , —C(O)R 39 , —OC(O)R 39 , —C(O)(CH 2 ) q R 39 , —S(O) 2 , —S(O) 2 NHR 39 , —S(O) 2 N(R 44 )(R 39 ), —N(R 44 )(R 39 ), —C(O)N(R 44 )(R 39 ) or —NHC(O)N(R 44 )(R 39 ); or optionally substituted C 1-6 alkyl, C 3-8 cycloalkyl, or C 5-8 aryl; and R 39 and R 44 are each independently H or optionally substituted C 1-6 alkyl, C 3-8 cycloalkyl or C 3-8 aryl; wherein each of the phenyl ring A carbon atoms 2-6 including its respective substituents are optionally replaced by N; or any pair of adjacent phenyl ring A carbons atoms 2-6 and their respective substituents are optionally replaced by S, N or O; and wherein n is an integer from 0 to 4; m is 0, 1 or 2; p is an integer from 1 to 3; q is an integer from 0 to 6; and x is either 0 or 1, provided that when x is 0, p is 1; or a pharmaceutically acceptable salt, ester or prodrug thereof.