Patent ID: 8877970

Claim:
A complex of formula I, its stereoisomer or pharmaceutically acceptable salt: wherein: V is a bond, O, C═O, C(═X)—NH, a group of or a group of wherein X is O or S; U is a bond or a group of (O—CH 2 —CH 2 —O) p —CH 2 —CH 2 wherein p is an integer ranging from 1 to 3; each W is independently a bond, O, or NH; Z is an aromatic, bicyclic aromatic, heteroaromatic, bicyclic heteroaromatic or heterocyclic ring; m is an integer ranging from 0 to 6; n is an integer ranging from 0 to 6; Metal represents a radionuclide selected from the group consisting of 99m Tc, 68 Ga, 62 Cu, 111 In, 186 Re, 188 Re, 90 Y, 212 Bi, 211 At, 89 Sr, 166 Ho, 153 Sm, 67 Cu, 64 Cu, 100 Pd, 212 Pb, 109 Pd, 68 Ga, 94 Tc, 105 Rh, 95 Ru, 177 Lu, and 170 Lu; and Chelate represents a chelating moiety that coordinates with said radionuclide to form said complex, and the Chelate is selected from the group consisting of tetra-azacyclododecanetetra-acetic acid (DOTA), diethylenetriaminepentaacetic acid (DTPA), bis(pyridin-2-ylmethyl)amine (DPA), quinolinemethylamino acetic acid (QAA), bis(isoquinolinemethyl)amine, bis(quinolinemethyl)amine (DQA), pyridine-2-ylmethylamino acetic acid (PAMA), isoquinolin-3-ylmethylamino acetic acid, bis(thiazol-2-ylmethyl)amine (DTK), and thiazol-2-ylmethylamino acetic acid (MTMA), bis(N-carboxymethylimidazoylamine) (DCMI), bis(N-1,1-dimethoxyethylimidazoylamine) (DMEI), bis(N-methylimidazoylamine) (DMI) and bis(N-hydroxyethylimidazoylamine) (DHI).