Patent ID: 8859514

Claim:
A modified compound 12 to 30 nucleobases in length targeted to a nucleic acid molecule encoding C-reactive protein, wherein said compound is at least 90% complementary to said nucleic acid molecule encoding C-reactive protein, wherein said compound comprises at least an 8 nucleobase portion of a sequence selected from any of SEQ ID NOS:77, 78, 79, 82, 83, 86, 87, 88, 93, 94, 95, 96, 103, 104, 105, 106, 107, 108, 109, 112, 113, 114, 115, 116, 117, 118, 119, 122, 123, 124, 125, 126, 127, 128, 129, 133, 135, 136, 137, 138, 143, 144, 147, 148, 158, 159, 160, 161, 162, 163, 167, 168, 169, 173, 177, 178, 179, 180, 181, 189, 192, 193, 194, 195, 196, 199, 204, 206, 207, 208, 211, 213, 214 and 215, wherein said modified compound comprises a modification selected from the group consisting of a modified sugar and a modified nucleobase, and wherein said compound inhibits the expression of C-reactive protein mRNA.