Patent ID: 6964956

Claim:
A compound of formula (I): wherein: R 1 is (a) phenyl or heteroaryl selected from furanyl, thienyl and pyridyl, optionally substituted with one to two R 3 , (b) R 6 (CH 2 ) m O—, (c) R 6 OCH 2 —, (d) R 6 (CH 2 ) m NH—, (e) R 6 (CH 2 ) p (CH═CH) m —, (t) C 1-6 alkyl, (g) C 1-6 alkylOH, (h) —CF 3 , (i) C 1-8 alkoxy, (j) —OC 1-6 alkylOH, (k) C 1-8 alkylthio, (l) —N(R 4 )(R 5 ), or (m)-C(O)NHR′, wherein R′ is R 6 , or pyridyl; R 2 is heterocyclyl wherein said heterocycle is selected from 1-piperidinyl, 1-piperazinyl, 4-morpholinyl, 1-azepanyl, 1-pyrrolidinyl, 1,4-diazacycloheptan-1-yl, 1-azepanyl 2,5-diazabicyclo[2.2.1]heptan-2-yl, oxazepan-4-yl and 4-thiomorpholino and is optionally substituted with one to three R 7 , R 3 is chosen from C 1-6 alkyl, C 1-6 alkoxy, hydroxyC 1-6 alkyl, halogen, —CN, —CO 2 H, —CO 2 C 1-6 alkyl, —S(O) n C 1-6 alkyl, —NO 2 , —OH, —CF 3 , —N(R 4 )(R 5 ), —NHC(O)NHC 1-6 alkyl, —C(O)N(R 4 )(R 5 ) and phenyl optionally substituted with halogen, C 1-6 alkyl, —CN or C 1-6 alkoxy; R 4 and R 5 are independently selected from H, C 1-6 alkyl, —C(O)C 1-6 alkyl, pyridyl, benzyl, piperidinyl and phenylethyl; R 6 is a phenyl group optionally substituted with one or two groups selected from Cl, F, C 1-6 alkyl, —CN, —CO 2 C 1-6 alkyl, —C(O)NR 4 R 5 , —SO 2 NH 2 , —NO 2 , —OH, —NH 2, —CF 3 and C 1-6 alkoxy, or R 6 is C 3-6 cycloalkyl, —CH 2 OH, naphthalene-2-yl, naphthalene-1-yl or 2-thienyl; R 7 is selected from —OH, —CN, oxo, —CO 2 C 1-6 alkyl, —CO 2 H, —C(O)N(R 4 )(R 5 ), —N(R 4 )(R 5 ), —CH 2 N(R 4 )(R 5 ), —CH 2 OH, C 1-6 alkyl, —C(O)C 1-6 alkylN(R 4 )(R 5 ), —NHC(O)N(R 4 )(R 5 ), —S(O) n C 1-6 alkyl, phenyl, pyridyl, H 2 NCH(R 8 )C(O)—, HO(CH 2 ) m CH 2 CH(NH 2 )C(O)—, —, R 6 CH 2 CH(OH)CH 2 NH—, R 6 OCH 2 CH(OH)CH 2 NH— and —C(O)heterocyclyl, wherein said heterocyclyl is selected from piperidinyl, piperazinyl, morpholinyl and pyrrolidinyl, or R 7 is 2-hydroxyethylamino, methylcarbamimidoyl, hydroxyimino, hydrozinocarbonyl, sulfamoyl, methanesulfonylamino, methylsulfonyihydrazino, 2-hydroxypropylamino, 2,3-dihydroxypropylamino, 2-hydroxy-1-methylethylamino, carbamoylmethylamino, N′-phenyihydrazinocarbonyl or toluene-4-sulfonylamino; R 8 is selected from C 1-6 alkyl, —(CH 2 ) 1-4 NH 2 , phenyl or benzyl; m is 0 or 1, n is 0, 1 or 2; and p is 0, 1, 2 or 3; or a pharmaceutically acceptable salt, racemate, racemic mixture, single enantiomer, diastereomeric mixture or individual diastereomer thereof.