Patent ID: 8729249

Claim:
An isolated nucleic acid chosen from: a) a DNA or RNA nucleic acid, coding for a monoclonal antibody comprising a heavy chain comprising complementarity determining regions (CDR) CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences SEQ ID Nos. 1, 2, and 3, respectively; a light chain comprising CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences SEQ ID Nos. 5, 6, and 7, respectively; and a modified hinge region comprising the amino acid sequence SEQ ID No. 28; b) a DNA or RNA nucleic acid comprising a DNA sequence comprising the sequences SEQ ID No. 11, SEQ ID No. 12, SEQ ID No. 13, and the sequences SEQ ID No. 15, SEQ ID No. 16, and SEQ ID No. 17; c) a DNA or RNA nucleic acid comprising a DNA sequence comprising the sequences SEQ ID No. 14 and SEQ ID No. 18, 19 or 20; d) the corresponding RNA nucleic acids of the DNA nucleic acids as defined in b) and c).