Patent ID: 8658665

Claim:
A method of treatment of a tauopathy condition or a disease of tau protein aggregation in a patient in need thereof comprising administering to the patient a compound of formula (I): wherein: X − is a counter ion; —R 5 is independently —H, or saturated C 1-6 alkyl, which is unsubstituted or substituted with one or more substituents —R 5A , or phenyl, which is unsubstituted or substituted with one or more substituents —R 5A ; each —R 5A is independently selected from —F, —Cl, —Br, —I, —OH, —OR 6 , —SH, —SR 6 , —CN, —NO 2 , —NH 2 , —NHR 6 , —NR 6 2 , —NHC(═O)R 6 , —NR 6 C(═O)R 6 , —C(═O)OR 6 , —OC(═O)R 6 , —C(═O)NH 2 , —C(═O)NHR 6 , and —C(═O)NR 6 2 , —C(═O)R 6 , —C(═O)OH, —S(═O)R 6 , —S(═O) 2 R 6 , and —S(═O) 2 OH; each —R 6 is independently saturated aliphatic C 1-4 alkyl, phenyl, or benzyl; —R 13a , —R 13b , —R 14a , —R 14b , —R 15a , —R 15b , —R 16a , and —R 16b are each independently selected from H and saturated aliphatic C 1-4 alkyl.