Patent ID: 6951855

Claim:
A compound of Formula (II) or a salt, pro-drug or solvate thereof, wherein: X is selected from: —O—, —S—, —S(O)—, —S(O 2 )—, —N(R 4 )— or —N(R 4 )CH 2 C(O)—; R 1 is independently selected from: amino, halo, hydroxy, —OPO 3 H 2 , C 1-4 alkyl, C 1-4 alkoxy, N-C 1-4 -alkylamino, N,N-di-C 1-4 alkylamino, C 1-4 alkanoylamino or C 1-4 alkylthio wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R 2 is selected from; hydrogen or C 1-4 alkyl; R 3 is selected from; hydrogen or C 1-4 alkyl; R 4 is selected from; hydrogen or C 1-4 alkyl; n is 0, 1 or 2; and p is 0, 1, 2 or 3; with the proviso that the following compounds are excluded: 6-benzyloxy-2H-1,4-benzoxazin-3(4H)-one; 7-benzyloxy-2H-1,4-benzoxazin-3(4H)-one; 2-methyl-7-benzyloxy-2H-1,4-benzoxazin-3(4H)-one; 2,4-dimethyl-7-benzyloxy-2H-1,4-benzoxazin-3(4H)-one; 2-methyl-7-(3,5-dichlorobenzyloxy)-2H-1,4-benzoxazin-3(4H)-one; 2,4-dimethyl-7-(3,5-dichlorobenzyloxy)-2H-1,4-benzoxazin-3(4H)-one; 7-phenylthio-2H-1,4-benzoxazin-3(4H)-one; 4-methyl-7-phenylthio-2H-1,4-benzoxazin-3(4H)-one; 4-methyl-7-phenylsulfinyl-2H-1,4-benzoxazin-3(4H)-one; and 6-phenylsulfonyl-2H-1,4-benzoxazin-3(4H)-one.