Patent ID: 6906181

Claim:
An isolated antibody that binds to a polypeptide selected from the group consisting of: a) a polypeptide encoded by a nucleic acid molecule which hybridizes in 0.1×SSC at 68° C. to a nucleic acid molecule consisting of SEQ ID NO:1, wherein 1) the polypeptide is a GPCR, 2) failure to express the polypeptide results in embryonic lethality in Drosophila, and 3) hypomorphic expression of the polypeptide increases resistance to heat stress in Drosophila; and b) a polypeptide consisting of an amino acid sequence which is at least 85% homologous to the amino acid sequence of SEQ ID NO:2, wherein 1) the polypeptide is a GPCR, 2) failure to express the polypeptide results in embryonic lethality in Drosophila, and 3) hypomorphic expression of the polypeptide increases resistance to heat stress in Drosophila, wherein the antibody binds to the amino acid sequence that is at least 85% homologous to SEQ ID NO:2.