Patent ID: 7235649

Claim:
An isolated nucleic acid molecule encoding a GRP94 ligand binding domain (LBD) polypeptide, the nucleic acid molecule consisting of: (a) a nucleotide sequence of any one of SEQ ID NOs:3 and 5; (b) an isolated nucleic acid molecule of at least 95% sequence identity to any one of SEQ ID NOs:3 and 5; or (c) an isolated nucleic acid molecule differing from the nucleic acid molecule of (a) or (b) above in nucleotide sequence due to the degeneracy of the genetic code, wherein said nucleic acid molecule encodes a GRP94 LBD polypeptide encoded by the nucleic acid molecule of (a) or (b) above, wherein the GRP94 ligand binding domain (LBD) polypeptide encoded by the isolated nucleic acid molecule of (a), (b) or (c) binds a GRP94 ligand selected from the group consisting of 4,4′-dianilino-1,1-binaphthyl-5,5-disulfonic acid (bis-ANS) and N-ethylcarboxamidoadenosine (NECA).