Patent ID: 8618097

Claim:
A compound of the Formula: and enantiomers and salts thereof, wherein: G is phenyl, naphthalene, a 5-6 membered heteroaryl or a 9-10 membered bicyclic heteroaryl wherein the phenyl, naphthalene, 5-6 membered heteroaryl or 9-10 membered bicyclic heteroaryl is optionally substituted with one to four R a groups; R 1 and R 1a are independently selected from H, Me, Et, â€”CHâ•CH 2 , â€”CH 2 OH, CF 3 , CHF 2 or CH 2 F; R 2 is H, â€”OH, â€”OMe or F; R 2a is H, Me or F, or R 2 and R 2a are oxo; R 3 is H, Me, Et, or CF 3 ; R 4 is H, 4-6 membered heterocycle, cyclopropylmethyl or C 1 -C 4 alkyl optionally substituted with F, â€”OH or â€”O(C 1 -C 3 alkyl); R 5 and R 5a are independently selected from H and C 1 -C 4 alkyl, or R 5 and R 5a together with the atom to which they are attached form a carbonyl group, a 5-6 membered cycloalkyl or a 5-6 membered heterocycle, wherein the heterocycle has an oxygen heteroatom; each R a is independently halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, â€”Oâ€”(C 1 -C 6 -alkyl), CF 3 , â€”OCF 3 , S(C 1 -C 6 -alkyl), CN, phenyl, â€”OCH 2 -phenyl, NH 2 , â€”NO 2 , â€”NHâ€”(C 1 -C 6 -alkyl), â€”Nâ€”(C 1 -C 6 -alkyl) 2 , piperidine, pyrrolidine, pyrazole, pyridine, 2-aminopyrimidine, CH 2 F, CHF 2 , â€”OCH 2 F, â€”OCHF 2 , â€”OH, â€”SO 2 (C 1 -C 6 -alkyl), C(O)NH 2 , C(O)NH(C 1 -C 6 -alkyl), and C(O)N(C 1 -C 6 -alkyl) 2 ; and j is 1 or 2; and when j is 2, the j ring carbon opposite NR 4 may be replaced with an O heteroatom.