Patent ID: 8604051

Claim:
A process for preparing a thieno-pyridine compound of Formula I or pharmaceutically acceptable salt or N-oxide thereof: (I) wherein: R 1 is hydrogen, halogen or C 1-6 alkyl; R 2 is halogen or C 1-6 alkyl; R 3 is hydrogen, cyano, —CO 2 R a , —CONR b R c or —CON(OR b )R c ; R a is C 1-6 alkyl; R b is hydrogen, optionally substituted C 1-6 alkyl, optionally substituted C 3-7 cycloalkyl, optionally substituted C 3-7 cycloalkyl(C 1-6 )alkyl, optionally substituted aryl, optionally substituted aryl(C 1-6 )alkyl, optionally substituted C 3-7 heterocycloalkyl, optionally substituted C 3-7 heterocycloalkyl(C 1-6 ) alkyl, optionally substituted heteroaryl or optionally substituted heteroaryl(C 1-6 ) alkyl; and R c is hydrogen or C 1-6 alkyl optionally substituted with one or more hydroxyl groups; or R b and R c , are taken together with the nitrogen atom to which they are attached to form a cyclic group selected from optionally substituted azetidinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted morpholinyl, optionally substituted thiomorpholinyl, optionally substituted piperazinyl, optionally substituted homopiperidinyl, optionally substituted homomorpholinyl and optionally substituted homopiperazinyl; said process comprising: contacting a compound of Formula III or an N-oxide thereof: wherein L 1 is a leaving group; with a compound of Formula IV: for a time and under conditions effective to provide the compound of Formula I or pharmaceutically acceptable salt or N-oxide thereof.