Patent ID: 7402581

Claim:
A compound of the formula (I), an enantiomer thereof, or a pharmaceutically acceptable salt of the compound or enantiomer, wherein: Het is selected from the group consisting of: A) piperidino, wherein the piperidino is: i) substituted with a substituent selected from the group consisting of hydroxy, hydroxyalkyl, oxo, methylthio, methylsulfinyl, methylsulfonyl, cyano, 1,3-dioxolan-2-yl, C 1 -C 4 alkoxy, amino, acylamino, and (C 1 -C 4 alkylsulfonyl)amino, wherein the amino is unsubstituted or optionally mono or disubstituted with a substituent selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl, and C 2 -C 4 alkynyl, and wherein the acylamino and the (C 1 -C 4 alkylsulfonyl)amino are unsubstituted or optionally N-substituted with a substituent selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl, and C 2 -C 4 alkynyl; ii) substituted with one or two fluoro atoms; or iii) disubstituted by C 1 -C 4 alkyl and/or hydroxy groups; B) morpholino or thiomorpholino, wherein the thiomorpholino is unsubstituted or optionally substituted at its sulfur atom by one or two oxygen atoms; and C) piperazino which is unsubstituted or optionally substituted at the 4-nitrogen atom by a substituent selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 4 cycloalkyl, C 1 -C 4 alkyl sulfonyl, and C 1 -C 4 acyl; R1 is hydrogen; R2 is fluoro attached at the 4-position; R3 is hydrogen; R4 is selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl, and C 2 -C 4 alkynyl; and Ar is phenyl substituted at its 3- and 5-positions by substituents independently selected from the group consisting of halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, cyano, and nitro; wherein one or more of the hydrogen atoms of the alkyl, cycloalkyl, alkenyl, alkynyl, and alkoxy groups may be optionally substituted for a fluorine atom.