Patent ID: 7132504

Claim:
A compound having the formula wherein: (a) R 1 and R 2 are each independently C 1-8 alkyl, C 3-7 cycloalkyl C 4-10 alkylcycloalkyl, C 1-6 alkoxy, C 6-10 aryl, C 7-14 alkylaryl, C 9-14 cycloalkylaryl, C 7-14 alkoxyaryl, C 9-14 cycloalkoxyaryl, 5–7 membered heteroaryl or C 7-14 alkylheteroaryl; or R 1 and R 2 , together with the nitrogen atom to which they are attached, join to form a 4–8 membered monocyclic heterocycle; (b) m is 1 or 2; (c) n is 1 or 2; (d) R 3 is H; or C 1-6 alkyl, C 2-6 alkenyl or C 3-7 cycloalkyl, each optionally substituted with halogen; (e) R 4 is C 1-8 alkyl optionally substituted with halo, cyano, amino, C 1-6 dialkylamino, C 6-10 aryl, C 7-14 alkylaryl, C 1-6 alkoxy, carboxy, hydroxy, aryloxy, C 7-14 alkylaryloxy, C 2-6 alkylester or C 8-15 alkylarylester; C 3-12 alkenyl; C 3-7 cycloalkyl or C 4-10 alkylcycloalkyl, wherein the cycloalkyl or alkylcycloalkyl are optionally substituted with hydroxy, C 1-6 alkyl, C 2-6 alkenyl or C 1-6 alkoxy; or R 3 together with the carbon atom to which it is attached forms a C 3-7 cycloalkyl group optionally substituted with C 2-6 alkenyl; (f) Y is H, phenyl substituted with nitro, pyridyl substituted with nitro, or C 1-6 alkyl optionally substituted with cyano, hydroxyl or C 3-7 cycloalkyl; provided that if R 5 or R 6 is H then Y is H; (g) B is H, C 1-6 alkyl, R 5 —(C═O)—, R 5 O(C═O)—, R 5 —N(R 6 )—C(═O)—, R 5 —N(R 6 )—C(═S)—, R 5 SO 2 —, or R 5 —N(R 6 )—SO 2 —; (h) R 5 is (i) C 1-10 alkyl optionally substituted with phenyl, carboxyl, C 1-6 alkanoyl, 1–3 halogen, hydroxy, —OC(O)C 1-6 alkyl, C 1-6 alkoxy, amino optionally substituted with C 1-6 alkyl, amido, or (lower alkyl)amido; (ii) C 3-7 cycloalkyl, C 3-7 cycloalkoxy, or C 4-10 alkylcycloalklyl, each optionally substituted with hydroxy, carboxyl, (C 1-6 alkoxy)carbonyl, amino optionally substituted with C 1-6 alkyl, amido, or (lower alkyl)amido; (iii) C 6-10 aryl or C 7-16 arylalkyl, each optionally substituted with C 1-6 alkyl, halogen, nitro, hydroxy, amido, (lower alkyl)amido, or amino optionally substituted with C 1-6 alkyl; (iv) Het; (v) bicyclo(1.1.1)pentane; or (vi) —C(O)OC 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; (i) R 6 is H; C 1-6 alkyl optionally substituted with 1–3 halogens; or C 1-6 alkoxy provided R 5 is C 1-10 alkyl; (j) X is O, S, SO, SO 2 , OCH 2 , CH 2 O or NH; (k) R′ is isoquinoline, C 6-10 aryl or C 7-14 alkylaryl, each optionally substituted with R a ; and (l) R a is C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkoxy, C 3-7 cycloalkoxy, halo-C 1-6 alkyl, CF 3 , mono- or di-halo-C 1-6 alkoxy, cyano, halo, thioalkyl, hydroxy, alkanoyl, NO 2 , SH, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, di(C 1-6 )alkylamide, carboxyl, (C 1-6 )carboxyester, C 1-6 alkylsulfone, C 1-6 alkylsulfonamide, di(C 1-6 )alkyl(alkoxy)amine, C 6-10 aryl, C 7-14 alkylaryl, or a 5–7 membered monocyclic heterocycle; or a pharmaceutically acceptable salt, solvate or prodrug thereof.