Patent ID: 8563550

Claim:
A compound of formula I, wherein: B represents —S—, —S(O)— or —SO 2 —; Z represents a direct bond, —(CH 2 ) n —O—, —(CH 2 ) n —S—, —(CH 2 ) n —N(R a )—, —(CH 2 ) n1 —S(O)—, —(CH 2 ) n —SO 2 —, —(CH 2 ) n —NH—SO 2 —, —(CH 2 ) n1 —SO 2 —NH—, —(CH 2 ) n —N(R a )—CO—, —(CH 2 ) n —NH—CO—NH— or —(CH 2 ) n —CO—N(R a )—; n represents, on each occasion when used herein, 0, 1 or 2; n1 represents, on each occasion when used herein, 1 or 2; M represents a direct bond; R 1 represents aryl where the aryl is optionally substituted with one or more substituents selected from B 3 ; X represents a direct bond; R 2 represents -T-Q; T represents a direct bond; Q represents C 3-6 heterocycloalkyl where the heterocycloalkyl group is optionally substituted by one or more substituents selected from B 6 , or heteroaryl where the heteroaryl group is optionally substituted by one or more substituents selected from B 8 ; B 3 , B 6 , and B 8 independently represent halo, —OR e , —C(O) 2 R e , —C(O)R e , —C(O)N(R e ) 2 , —N(R e )—C(O)—R e , —CN, —S(O) 2 R e , —S(O) 2 N(R e ) 2 , —N(R e ) 2 and/or C 1-4 alkyl optionally substituted by one or more substituents selected from halo, —OR e and —C(O) 2 R e ; or, B 6 may alternatively and independently represent ═O; R 3 represents hydrogen, halo, —R f , —OR f , —SR f , cyano or —N(R f ) 2 ; R a , R e and R f represent independently, on each occasion when used herein, hydrogen, phenyl optionally substituted by one or more halo and/or C 1-3 alkyl substituents and/or C 1-4 alkyl optionally substituted with one or more substituents selected from halo, —OR h and —N(R h ) 2 ; R h represents, on each occasion when used herein, hydrogen or C 1-3 alkyl optionally substituted by one or more halo atoms, or a pharmaceutically acceptable ester, amide, solvate or salt thereof, provided that when B represents —S—, X, Z and M all represent direct bonds, R 3 represents hydrogen, then R 2 does not represent 1-piperidinyl when R 1 represents unsubstituted phenyl.