Patent ID: 7727977

Claim:
A method for treating diabetes or a complication thereof comprising administering to a patient in need thereof an effective amount of one of the following compounds 2-benzylthio-4-phenyl-4-oxobutanoic acid; 2-(4′-methylphenylthio)-4phenyl-4-oxobutanoic acid; 2-(4′-chlorophenylthio)-4phenyl-4-oxobutanoic acid; 2-(4′-fluorophenylthio)-4phenyl-4-oxobutanoic acid; 2-(4′-methoxyphenylthio)4phenyl-4-oxobutanoic acid; 2-phenylthio-4-phenyl-4-oxobutanoic acid; 2-carboxymethylthio-4-phenyl-4-oxobutanoic acid; 2-cyclohexylthio-4-phenyl-4-oxobutanoic acid; 2-(2′-naphthylthio)-4-phenyl-4-oxobutanoic acid; ethyl 2-phenylthio-4-phenyl-4-oxobutanoate; ethyl 2-(4′-fluorophenylithio)-4-phenyl-4-oxobutanoate; ethyl 2-(4′-chlorophenylthio)-4-phenyl-4-oxobutanoate; ethyl 2-(4′-methylphenylthio)-4-phenyl-4- oxobutanoate; ethyl 2-(4′-methoxyphenylthio)-4-phenyl-4- oxobutanoate; ethyl 2-(2′-naphthylthio)-4phenyl-4-oxobutanoate; ethyl 2-cyclohexylthio-4-phenyl-4-oxobutanoate; ethyl 2-benzylthio-4-phenyl-4-oxobutanoate; 2-phenylthio-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-(4′-fluorophenylthio)-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-(4′-chlorophenylthio)-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-(4′-methylphenylithio)-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-(4′-methoxyphenylthio)-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-(2′-naphthylthio)-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-cyclohexylthio-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-benzylthio-4-(4′-methoxyphenyl)-4-oxobutanoic acid; 2-phenylthio-4-(4′-chlorophenyl)-4-oxobutanoic acid; 2-(4′-fluorophenylthio)-4-(4′-chlorophenyl)-4-oxobutanoic acid; 2-(4′-methylphenylthio)-4-(4′-chlorophenyl)-4-oxobutanoic acid; 2-(4′-methoxyphenylithio)-4-(4′-chlorophenyl)-4-oxobutanoic acid; 2-(2′-naphthylthio)4(4′-chlorophenyl)-4-oxobutanoic acid; or or a geometrical or optical isomer thereof, or a tautomeric form thereof; or a salt thereof with a pharmaceutically acceptable acid or base.