Patent ID: 8840891

Claim:
An isolated human monoclonal or recombinant antibody for the Thyroid Stimulating Hormone Receptor (TSHR), wherein said antibody is an antagonist of Thyroid Stimulating Hormone (TSH), and has a binding affinity for full length human TSHR of about 10 9 L/mol, and wherein said antibody comprises a V H region comprises the following Complement Determining Regions (CDRs): a) SNYMS (CDR1) (SEQ ID NO: 1); b) VTYSGGSTSYADSVKG (CDR2) (SEQ ID NO: 2); and c) GGRYCSSISCYARSGCDY (CDR3) (SEQ ID NO: 3); and said antibody comprises a V L region comprises the following CDRs: a) RASQSISNYLN (CDR1) (SEQ ID NO: 4); b) AASSLQS (CDR2) (SEQ ID NO: 5); and c) QQSYSSPSTT (CDR3) (SEQ ID NO: 6).