Patent ID: 8555878

Claim:
A manually-actuated device for delivering a substance to the nasal airway of a subject, comprising: a flow resistor; and a nosepiece shaped and sized for insertion into a nostril of the subject comprising an outlet through which a substance may be delivered into the nasal airway of the subject, and a sealing member configured to seal the one nostril of the subject to the outlet, the sealing member having a first, distal end and a second, proximal end and being enlarged towards the proximal end to cause an anterior region of the nasal cavity into which the nosepiece is inserted to be enlarged; and a substance supply unit in fluid communication with the outlet of the nosepiece and including a dispensing unit which is manually actuated to dispense a metered dose of substance into an exhalation air flow, wherein the exhalation air flow has a flow rate of at least 10 liters per minute; wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject.