Patent ID: 7840263

Claim:
A system, comprising: an implantable gene regulatory signal delivery device that emits, in response to a gene regulatory control signal, a regulatory signal which regulates transcription from a regulatable transcriptional control element; an implantable cardiac rhythm management (CRM) device including: a sensor to sense a physiological signal indicative of a predetermined cardiac condition; an event detector configured to detect the predetermined cardiac condition from the sensed physiological signal and produce one or more condition parameters related to one of a type and a degree of the predetermined cardiac condition; and a controller coupled to the sensor and electrically connected to the gene regulatory signal delivery device, the controller configured to produce the gene regulatory control signal, transmit the gene regulatory signal to the gene regulatory signal delivery device to trigger an emission of the regulatory signal in response to a detection of the predetermined cardiac condition, and quantitatively control the emission of the regulatory signal based on the one or more condition parameters; and one or more implantable leads providing for electrical connections between the implantable gene regulatory signal delivery device and the implantable CRM device, wherein the controller is electrically wired to the gene regulatory signal delivery device through the electrical connections, and wherein the regulatory signal is selected to regulate the regulatable transcriptional control element in a vector having the regulatable transcriptional control element operably linked to an open reading frame, the expression of which treats the predetermined cardiac condition.