Patent ID: 6893637

Claim:
A method of reducing cell proliferation or extracellular matrix production caused by zvegf3 in a mammal comprising administering to the mammal a composition comprising a zvegf3 antagonist in combination with a pharmaceutically acceptable delivery vehicle, in an amount sufficient to reduce zvegf3 activity, wherein said zvegf3 antagonist is an antibody that specifically binds to a dimeric protein consisting of two polypeptide chains, wherein each of said polypeptide chains consists of a sequence of amino acid residues selected from the group consisting of: residues 230-345 of SEQ ID NO:2; residues 231-345 of SEQ ID NO:2; residues 232-345 of SEQ ID NO:2; residues 233-345 of SEQ ID NO:2; residues 234-345 of SEQ ID NO:2; residues 235-345 of SEQ ID NO:2; residues 236-345 of SEQ ID NO:2; residues 237-345 of SEQ ID NO:2; residues 238-345 of SEQ ID NO:2; residues 239-345 of SEQ ID NO:2; and residues 240-345 of SEQ ID NO:2, whereby administration of the composition to the mammal results in reduction of cell proliferation or extracellular matrix production caused by zvegf3.