Patent ID: 7776335

Claim:
A method of preventing or treating a Neisseria infection in a subject comprising administering to the subject a pharmaceutical composition that comprises (a) a pharmaceutically acceptable excipient and (b) a pharmaceutically effective amount of a polypeptide wherein the polypeptide is selected from: (i) a polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence set forth in SEQ ID NO:2, wherein the polypeptide is capable of inducing an immunological response against Neisseria and is capable of eliciting an antibody that specifically binds to a protein comprising the amino acid sequence set forth in SEQ ID NO:2; (ii) a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, or SEQ ID NO:8; (iii) a polypeptide comprising a polypeptide fragment of the amino acid sequence set forth in any one of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8, wherein the polypeptide fragment comprises at least one immunogenic epitope, and wherein the polypeptide fragment is capable of eliciting an antibody that specifically binds to a protein comprising the amino acid sequence set forth in SEQ ID NO:2 and is capable of inducing an immunological response against Neisseria; (iv) a polypeptide comprising the amino acid sequence set forth at residue 51 to residue 86 of SEQ ID NO:2 wherein the isolated polypeptide is capable of inducing an immunological response against Neisseria and is capable of eliciting an antibody that specifically binds to a protein comprising the amino acid sequence set forth in SEQ ID NO:2; and (v) a polypeptide comprising the amino acid sequence set forth at residue 110 to residue 140 of SEQ ID NO:2 wherein the isolated polypeptide is capable of inducing an immunological response against Neisseria and is capable of eliciting an antibody that specifically binds to a protein comprising the amino acid sequence set forth in SEQ ID NO:2.