Patent ID: 7498414

Claim:
An isolated human antibody or fragment thereof which binds selectively to KDR, comprising complementarity determining regions represented by amino acid sequences selected from the group consisting of: (a) SEQ ID NO:1 at CDRL1, SEQ ID NO:2 at CDRL2, SEQ ID NO:3 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (b) SEQ ID NO:4 at CDRL1, SEQ ID NO:5 at CDRL2, SEQ ID NO:6 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (c) SEQ ID NO:7 at CDRL1, SEQ ID NO:8 at CDRL2, SEQ ID NO:9 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; d) SEQ ID NO:10 at CDRL1, SEQ ID NO:11 at CDRL2, SEQ ID NO:12 at CDRL3, SEQ ID NO:16 at CDRH1, SEQ ID NO:17 at CDRH2, and SEQ ID NO:18 at CDRH3; (e) SEQ ID NO:54 at CDRL1, SEQ ID NO:55 at CDRL2, SEQ ID NO:56 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (f) SEQ ID NO:57 at CDRL1, SEQ ID NO:58 at CDRL2, SEQ ID NO:59 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (g) SEQ ID NO:60 at CDRL1, SEQ ID NO:61 at CDRL2, SEQ ID NO:62 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (h) SEQ ID NO:63 at CDRL1, SEQ ID NO:64 at CDRL2, SEQ ID NO:65 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; i) SEQ ID NO:66 at CDRL1, SEQ ID NO:67 at CDRL2, SEQ ID NO:68 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (j) SEQ ID NO:69 at CDRL1, SEQ ID NO:70 at CDRL2, SEQ ID NO:71 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (k) SEQ ID NO:72 at CDRL1, SEQ ID NO:73 at CDRL2, SEQ ID NO:74 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (1) SEQ ID NO:75 at CDRL1, SEQ ID NO:76 at CDRL2, SEQ ID NO:77 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; (m) SEQ ID NO:78 at CDRL1, SEQ ID NO:79 at CDRL2, SEQ ID NO:80 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3; and (n) SEQ ID NO:81 at CDRL1, SEQ ID NO:82 at CDRL2, SEQ ID NO:83 at CDRL3, SEQ ID NO:13 at CDRH1, SEQ ID NO:14 at CDRH2, and SEQ ID NO:15 at CDRH3.