Patent ID: 8486918

Claim:
A compound is presented by Formula I, its enantiomers, diastereoisomers, hydrates, tautomers or a pharmaceutically acceptable salt thereof, wherein: A is C 6-10 aryl, heterocycle, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; B is C 6-10 aryl, heterocycle, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; R 1 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 2 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 3 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 4 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 5 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 6 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 7 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; R 8 is independently halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 13 , NR 14 R 15 or hydroxyl; L 1 is O, C(O), S or NH; R 9 is O, S, C(O) or CH 2 ; R 10 is H or C 1-8 alkyl; L 2 is CHR 16 , O, S, NR 17 ,direct bond or —C(O)—; R 11 is H, OPO 3 H 2 , carboxylic acid, PO 3 H 2 , C 1-8 alkyl, —S(O) 2 H, —P(O)MeOH, —P(O)(H)OH or OR 12 ; R 12 is H or C 1-8 alkyl; a is 0, 1 or 2; b is 0 or 1; c is 0, 1, 2 or 3; R 13 is H, C 1-8 alkyl; R 14 is H or C 1-8 alkyl; and R 15 is H or C 1-8 alkyl; R 16 is H, OH or C 1-8 alkyl; and R 17 is H or C 1-8 alkyl.