Patent ID: 8314934

Claim:
A method of detecting and collecting one or more sample components within a first sample stream in a chromatography system during a chromatographic run comprising: separating one or more sample components from a fluid mixture using a chromatography column to form the first sample stream; separating the first sample stream into two distinct streams by actively moving a portion of the first sample stream to a second sample stream, which is in fluid communication with at least one destructive detector, including at least one evaporative particle detector; generating a first signal during the chromatographic run from the destructive detector; generating a second signal during the chromatographic run from at least one non-destructive detector, which is in fluid communication with either said first stream or said second stream; and collecting the one or more components from the first sample stream in a fraction collector during the chromatographic run in response to a change in at least one of the signals during said chromatographic run.