Patent ID: 7218964

Claim:
A system to perform closed loop controlled delivery of electrical stimulation to excitable neural tissue of a portion of the spine of a body, comprising: a sensing circuit to sense at least one physiologic parameter and provide an output signal related thereto, wherein said sensing circuit operatively couples to a sensor adapted to sense a change in paraspinal muscle tone; a stimulation circuit to provide the electrical stimulation to excitable neural tissue of a portion of the spine in response to the output signal; a drug dispensing apparatus coupled to a catheter and adapted to deliver biologically-active agents via the catheter to the body; and a closed loop control circuit coupled to the sensing circuit, to the stimulation circuit, and to the drug dispensing apparatus configured to control the stimulation circuit and the drug dispensing apparatus based on anticipation of an occurrence of a cardiac insult as indicated by the at least one physiologic parameter, wherein at least one input to said closed loop control circuit includes the output signal from said sensing circuit.