Patent ID: 7671052

Claim:
A compound of formula I: wherein: R 1 , R 2 , R 3 , and R 4 are each independently H, alkyl, —OR 9a , —N(R 10 )(R 11 ), —C(═O)N(R 12 )(R 13 ), —C(═O)—OR 9b , —OP(═O)(OR 9c )(OR 9d ), —CN, or R 5 and R 6 are each independently H or alkyl, or taken together with the carbon atom to which they are attached form a 3- to 8-membered carbocyclic ring, wherein 1 to 3 of the ring carbon atoms independently may be optionally replaced by —O—, —S—, —S(═O)—, —S(═O) 2 —, or —N(R 9e )—; R 7 is H, alkyl, halogen, or —OR 9f ; each R 8 is independently H or alkyl; A, B, D, and E are each independently N, CR 14a , C—[C(R 15a )(R 16a )] p —N(R 17 )-G 1 , or C—[C(R 15b )(R 16b )] p —OC(═O)—N(R 18a )(R 18b ); J is N or CR 14b , provided that no more than two of A, B, D, E, and J are N; each G 1 is independently —S(═O) 2 R 19 , —S(═O) 2 N(R 20a )(R 20b ), —C(═O)-heterocycloalkyl, —C(═O)-heteroaryl, —C(═O)—N(R 18c )(R 18d ), —C(═CHNO 2 )—N(R 18c )(R 18d ), or —C(═N—CN)—N(R 18e )(R 18f ); G 2 is acyl; each R 9a , R 9b , R 9c , R 9d , R 9e , and R 9f is independently H or alkyl; each R 10 , R 11 , R 12 , and R 13 is independently H, alkyl, alkenyl, aryl, or heteroaryl, or each R 10 and R 11 or R 12 and R 13 , taken together with the nitrogen atom to which they are attached, independently form a 4- to 8-membered heterocyclic ring wherein 1 or 2 of the ring carbon atoms independently may be optionally replaced by —O—, —S—, —S(═O)—, —S(═O) 2 —, —NH—, —N(alkyl)-, —N(C(═O)—R 9a )—, or —N(S(═O) 2 —R 9a )—; each R 14a and R 14b is independently H, halogen, alkyl, —CH 2 F, —CHF 2 , —CF 3 , —CN, —(CH 2 ) r- OH, or —(CH 2 ) r —O-alkyl; each R 18a , R 18b , R 18c , R 18d , R 18e , R 18f , R 20a , and R 20b is independently H, alkyl, alkenyl, or aryl, or each R 18a and R 18b or R 18c and R 18d or R 20a and R 20b , taken together with the nitrogen atom to which they are attached independently form a 4- to 8-membered heterocyclic ring wherein 1 or 2 of the ring carbon atoms independently may be optionally replaced by —O—, —S—, —S(═O) 2 —, —NH—, —N(alkyl)-, —N(C(═O)—R 9a )—, or —N(S(═O) 2 —R 9a ) —; each R 19 is independently H, alkyl, aryl, OH, or —O-alkyl; W is a single bond; X is —N(R 21 )—; each R 15a , R 15b , R 16a , R 16b , R 17 , and R 21 is independently H or alkyl; or R 17 and R 18c , taken together with the atoms through which they are connected form a 4- to 8-membered heterocyclic ring wherein 1 or 2 of the ring carbon atoms independently may be optionally replaced by —O—, —S—, —S(═O)—, —S(═O) 2 —, —NH—, —N(alkyl)-, —N(C(═O)—R 9a )—, or —N(S(═O) 2 —R 9a )—; m is 1; n is 2; each p is independently an integer from 0 to 5; and each r is independently an integer from 0 to 4; with the proviso that: at least one of A, B, D, and E is C—[C(R 15a )(R 16a )] p —N(R 17 )-G 1 or C—[C(R 15b )(R 16b )] p —OC(═O)—N(R 18a )(R 18b ); or a pharmaceutically acceptable salt thereof.