Patent ID: 7504412

Claim:
A compound of formula [I] wherein: each R 1 and R 2 are independently selected from the group consisting of: (1) hydrogen (2) halogen (3) C 1-6 alkyl (4) C 3-8 cycloalkyl-C 0-4 alkyl (5) C 1-6 alkylamino (6) di-C 1-6 alkylamino (7) C 1-6 alkylcarbonylamino (8) C 1-6 alkylcarbonyl-(C 1-6 alkyl)amino, and (9) 3 to 8-membered heterocycloalkyl-C 0-4 alkyl, wherein the C 1-6 alkyl moiety may be substituted with R 5 , the cycloalkyl or heterocycloalkyl moiety may be substituted with R 6 , and R 1 and R 2 are not hydrogen at the same time, or R 1 and R 2 together form —(CH 2 ) m —, m standing for an integer of 3-6, wherein 1 or 2 hydrogen atoms constituting methylene may be substituted with R 6 ; R 3 is hydrogen, halogen, C 1-6 alkyl or C 1-6 alkyloxy; R 4 is hydrogen or C 1-6 alkyl; each R 5 is independently selected from the group consisting of halogen, cyano, hydroxyl, amino, optionally fluorine- or hydroxyl-substituted C 1-6 alkyl, mono-C 1-6 alkylamino, di-C 1-6 alkylamino, optionally fluorine-substituted C 1-6 alkyloxy, C 1-6 alkyloxy-C 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxy-carbonylamino, C 1-6 alkyloxycarbonyl-(C 1-6 alkyl)amino, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylcarbonylamino, C 1-6 alkylcarbonyl-(C 1-6 alkyl)amino, carbamoyl, mono-C 1-6 alkylcarbamoyl, di-C 1-6 alkylcarbamoyl, carbamoylamino, mono-C 1-6 alkylcarbamoylamino, di-C 1-6 alkylcarbamoylamino, mono-C 1-6 alkylcarbamoyl-(C 1-6 alkyl)amino, di-C 1-6 alkylcarbamoyl-(C 1-6 alkyl)amino, carbamoyloxy, mono-C 1-6 alkylcarbamoyloxy, di-C 1-6 alkylcarbamoyloxy, C 1-6 alkylsulfonyl, C 1-6 alkylsulfonylamino, C 1-6 alkylsulfonyl-(C 1-6 alkyl)amino, sulfamoyl, mono-C 1-6 alkylsulfamoyl, di-C 1-6 alkylsulfamoyl, sulfamoylamino, mono-C 1-6 alkylsulfamoylamino, di-C 1-6 alkylsulfamoylamino, mono-C 1-6 alkylsulfamoyl-(C 1-6 alkyl)amino, di-C 1-6 alkylsulfamoyl-(C 1-6 alkyl)amino and pyridone; R 6 is R 5 or oxo; W is: (1) 1,4-piperidin-di-yl, (2) mono- or bi-cyclic, 3 to 8-membered aromatic heterocyclic group, (3) mono- or bi-cyclic, 3 to 8 membered aromatic or aliphatic carbocyclic group, (4) C 2-4 alkylene in which the carbon in the main chain may be substituted with oxygen, or (5) C 2-4 alkenylene in which the carbon in the main chain may be substituted with oxygen, wherein those substituents in above (2) through (5) may be optionally substituted with R 5 ; and Ar is an R 7 -substituted aromatic carbocyclic group or aromatic heterocyclic group, said aromatic carbocyclic group or aromatic heterocyclic group selected from the group consisting of: (1) phenyl, (2) naphthyl, (3) pyridinyl, (4) pyrimidinyl, (5) pyridazinyl, (6) pyrazyl, (7) pyrazole, (8) pyrrolyl, (9) imidazolyl, (10) triazolyl, (11) oxazolyl, (12) isoxazolyl, (13) oxadiazolyl, (14) thiazolyl, (15) isothiazolyl, (16) thiadiazolyl, and (17) tetrazolyl; wherein R 7 is selected from R 5 ; or a pharmaceutically acceptable salt thereof.