Patent ID: 7674907

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is NR 6 R 7 , OR 6 or SR 6 ; R 2 is phenyl substituted by 0, 1, 2, 3 or 4 substituents independently selected from R b or R c ; R 3 is phenyl substituted by 0, 1, 2, 3 or 4 substituents independently selected from R b or R c ; R 4 is R a or R c ; R 5 is R a or R c ; R 6 is —R 61 , —R 62 , —R 61 —R 62 , —R 61 —R 64 , —R 62 —R 64 , —R 61 —R 62 —R 64 , —R 61 —R 63 —R 62 , —R 61 —R 63 —R 64 , —R 62 —R 63 —R 64 , —R 61 —R 63 —R 62 —R 64 or —R 61 —R 62 —R 63 —R 64 , any of which is substituted by 0, 1, 2, 3 or 4 substituents independently selected from R c ; R 7 is R a or R c ; R 61 is, independently at each instance, a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups; R 62 is, independently at each instance, C 1-8 alkyl or C 1-8 alkoxyl; R 63 is, independently at each instance, —C(═O)—, —C(═O)O—, —C(═O)NR a —, —C(═NR a )NR a —, —O—, —OC(═O)—, —OC(═O)NR a —, —OC(═O)N(R a )S(═O) 2 —, —OC 2-6 alkylNR a —, —OC 2-6 alkylO—, —S—, —S(═O)—, —S(═O) 2 —, —S(═O) 2 NR a —, —S(═O) 2 N(R a )C(═O)—, —S(═O) 2 N(R a )C(═O)O—, —S(═O) 2 N(R a )C(═O)NR a —, —N(R a )—, —N(R a )C(═O)—, —N(R a )C(═O)O—, —N(R a )C(═O)N(R a )—, —N(R a )C(═NR a )N(R a )—, —N(R a )S(═O) 2 —, —N(R a )S(═O) 2 N(R a )—, —NR a C 2-6 alkylN(R a )— or —NR a C 2-6 alkylO—; R 64 is, independently at each instance, a saturated or unsaturated 5-, 6-or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups; R a is, independently at each instance, H or R b ; R b is, independently at each instance, C 1-8 alkyl, phenyl, piperizinyl, pyridyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrrolyl, imidazolyl, pyrrolidinonyl, pyranyl, tetrahydrofuryl, tetrahydropyranyl, dithiolidinyl, trialkoxysilyl, trialkylsilyl, cyclobutyl, cyclopentyl, cyclolhexyl, or benzyl, each of which is optionally substituted with C 1-8 alkyl, C 1-4 haloalky, F, Cl, Br, I, CN and NO 2 ; and R c is, independently at each instance, C 1-8 alkyl, C 1-4 haloalkyl, F, Cl, Br, I, CN, NO 2 , —C(═O)R b , —C(═O)OR a , —C(═O)NR a R a , —C(═NR a )NR a R a , —OR a , —OC 2-6 alkylR a , —OC(═O)R b , —OC(═O)NR a R a , —OC(═O)N(R a )S(═O) 2 R b , —OC 2-6 alkylNR a R a , —OC 2-6 alkylOR a , —SR a , —S(═O)R b , —S(═O) 2 R b , —S(═O) 2 NR a R a , —S(═O) 2 N(R a )C(═O)R b , —S(═O) 2 N(R a )C(═O)OR b , —S(═O) 2 N(R a )C(═O)NR a R a , —NR a R a , —N(R a )C(═O)R b , —N(R a )C(═O)OR b , —N(R a )C(═O)NR a R a , —N(R a )C(═NR a )NR a R a , —N(R a )S(═O) 2 R b , —N(R a )S(═O) 2 NR a R a , —NR a C 2-6 alkylNR a R a or —NR a C 2-6 alkylOR a .