Patent ID: 8309596

Claim:
A modulator of kallikrein 7 which is a compound of formula Or a salt thereof wherein R 1 is cyano, (C 1-8 )alkyl, (C 2-8 )alkenyl, (C 2-8 )alkynyl, halogen, (C 1-8 )alkylamino, (C 1-8 )alkylamino(C 1-8 )alkyl, (C 1-8 )alkoxy, or halo(C 1-8 )alkyl, X is CH═CH, NH, N═CH, O or S, Y is a group of formula wherein the N-containing ring system is optionally annelated with (C 3-8 )cycloalkyl, (C 6-18 )aryl or heterocyclyl having 5 to 6 ring members and 1 to 4 heteroatoms selected from N, O, S, n is 1, 2 or 3, R 2 is (C 1-8 )alkyl, (C 1-8 )alkylamino, (C 1-8 )alkylamino(C 1-8 )alkyl, di(C 1-8 )alkylamino(C 1-8 )alkyl, halo(C 1-8 )alkyl, (C 1-8 )alkoxy, (C 1-8 )alkoxy(C 1-8 )alkyl, or (CH 2 ) m —Z, wherein Z is unsubstituted or substituted (C 3-8 )cycloalkyl, (C 6-18 )aryl or heterocyclyl having 5 to 6 ring members and 1 to 4 heteroatoms selected from N, O, S; and m is 1 or 2, R 3 is hydrogen, (C 1-8 )alkyl, (C 1-8 )alkoxy, (C 6-18 )aryl or heterocyclyl having 5 to 6 ring members and 1 to 4 heteroatoms selected from N, O, S.