Patent ID: 8163475

Claim:
A method for diagnosing bipolar disorder in a subject, said method comprising the steps: (a) obtaining a cell sample from said subject, wherein said sample is a blood sample; (b) subjecting a cell from said sample to stress; and (c) measuring the level of expression in said cell of at least three nuclear encoded mitochondrial energy metabolism nucleic acids or polypeptides, wherein a decrease in said level of expression, as compared to the expression in a cell that is subjected to said stress from a sample obtained from a control subject, is indicative of said subject having bipolar disorder, wherein at least three of said nucleic acids or polypeptides are selected from the group consisting of NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13 kDa (NDUFA5; Entrez Gene ID:4698); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14 kDa (NDUFA6; Entrez Gene ID:4700); NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa (NDUFB1; Entrez Gene ID: 4707); ubiquinol-cytochrome c reductase binding protein (UQCRB; Entrez Gene ID: 7381); ubiquinol-cytochrome c reductase core protein II (UQCRC2; Entrez Gene ID: 7385); ubiquinol-cytochrome c reductase hinge protein (UQCRH; Entrez Gene ID: 7388); cytochrome c oxidase subunit IV isoform 1 (COX4I1; Entrez Gene ID: 1327); cytochrome c oxidase subunit VIIa polypeptide 2 like (COX7A2L; Entrez Gene ID: 9167); cytochrome c oxidase subunit VIIc (COX7C; Entrez Gene ID: 1350); COX11 homolog, cytochrome c oxidase assembly protein (yeast) (COX11; Entrez Gene ID: 1353); COX15 homolog, cytochrome c oxidase assembly protein (yeast) (COX15: Entrez Gene ID: 1355); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) (ATP5G2; Entrez Gene ID: 517); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G (ATP5L; Gene ID: 10632); ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (ATP5O; Entrez Gene ID No: 539); and ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) (ATP5S; Entrez Gene ID No: 27109).