Patent ID: 7452896

Claim:
A compound of the general formula I, wherein R 1 represents lower alkyl-O—(CH 2 ) n —, cycloalkyl-O—(CH 2 ) n —, cycloalkyl-CH 2 —O—(CH 2 ) n —; R 2 represents —CH 3 ; R a —Y—(CH 2 ) m —; R 3 represents aryl; heteroaryl; R 4 represents hydrogen; trifluoromethyl; lower alkyl; lower alkyl-amino; lower alkyloxy; lower alkyloxy-lower alkyloxy; hydroxy-lower alkyloxy; lower alkyl-sulfinyl; lower alkylthio; lower alkylthio-lower alkyl; hydroxy-lower alkyl; lower alkyloxy-lower alkyl; hydroxy-lower alkyloxy-lower alkyl; hydroxy-lower alkyl-amino; lower alkylamino-lower alkyl; amino; di-lower alkylamino; [N-(hydroxy-lower alkyl)-N-(lower alkyl)]-amino; aryl; arylamino; aryl-lower alkylamino; aryl-thio; aryl-lower alkylthio; aryloxy; aryl-lower alkyloxy; aryl-lower alkyl; arylsulfinyl; heteroaryl; heteroaryl-oxy; heteroarylamino; heteroarylthio; heteroaryl-lower alkyl; heteroarylsulfinyl; heterocyclyl; heterocyclyl-lower alkyloxy; heterocyclyloxy; heterocyclylamino; heterocyclyl-lower alkylamino; heterocyclylthio; heterocyclyl-lower alkylthio; heterocyclyl-lower alkyl; heterocyclylsulfinyl; cycloalkyl; cycloalkyloxy; cycloalkyl-lower alkyloxy; cycloalkylamino; cycloalkyl-lower alkylamino; cycloalkylthio; cycloalkyl-lower alkylthio; cycloalkyl-lower alkyl; cycloalkylsulfinyl; R 6 represents hydrogen or methyl; X represents oxygen; sulfur; —CH 2 — or a bond; Y represents a bond, —O—; —NH—; —SO 2 —NH—; —NH—SO 2 —NH—; —O—CO—; —CO—O—; —O—CO—NH—; —NH—CO—O—; —NH—CO—NH—; n represents the integers 2, 3, or 4; m represents the integers 2, 3, or 4; and R a represents aryl, heteroaryl, lower alkyl, cycloalkyl, hydrogen; and optically pure enantiomers, mixtures of enantiomers, optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and the meso-forms and pharmaceutically acceptable salts thereof.