Patent ID: 7851638

Claim:
A compound of formula I: wherein: R 1 is —(CH 2 ) n —R 1a , wherein n is independently 0-6, and R 1a is selected from the group consisting of: (1) C 1-6 alkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxy, (2) phenyl substituted with R 2a , R 2b and R 2c , (3) heterocycle substituted with R 2a , R 2b and R 2c , (4) C 3-6 cycloalkyl, which is unsubstituted or substituted with C 1-6 alkyl, 1-6 halogen, hydroxy or —NR 10 R 11 , (5) —O—C 1-6 alkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxy or —NR 10 R 11 , (6) —CO 2 R 9 , wherein R 9 is independently selected from: (a) hydrogen, (b) —C 1-6 alkyl, which is unsubstituted or substituted with 1-6 fluoro, (c) benzyl, and (d) phenyl, (7) —NR 10 R 11 , wherein R 10 and R 11 are independently selected from: (a) hydrogen, (b) —C 1-6 alkyl which is unsubstituted or substituted with hydroxy, 1-6 fluoro or —NR 12 R 13 , where R 12 and R 13 are independently selected from hydrogen and —C 1-6 alkyl, (c) —C 3-6 cycloalkyl, which is unsubstituted or substituted with hydroxy, 1-6 fluoro or —NR 12 R 13 , (d) benzyl, (e) phenyl, and (8) —CONR 10 R 11 ; R 2 is selected from the group consisting of: (1) phenyl, which is substituted with R 2a , R 2b and R 2c , (2) heterocycle, which is substituted with R 2a , R 2b and R 2c , (3) C 1-8 alkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxy, —NR 10 R 11 , phenyl or heterocycle, where the phenyl or heterocycle is substituted with R 2a , R 2b and R 2c , (4) C 3-6 cycloalkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxy or —NR 10 R 11 , and (5) —C 1-6 alkyl-(C 3-6 cycloalkyl), which is unsubstituted or substituted with 1-6 halogen, hydroxy or —NR 10 R 11 ; R 2a , R 2b and R 2c are independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —C 1-6 alkyl, which is unsubstituted or substituted with: (a) 1-6 halogen, (b) phenyl, (c) C 3-6 cycloalkyl, or (d) —NR 10 R 11 , (4) —O—C 1-6 alkyl, which is unsubstituted or substituted with 1-6 halogen, (5) hydroxy, (6) —SCF 3 , (7) —SCHF 2 , (8) —SCH 3 , (9) —CO 2 R 9 , (10) —CN, (11) —SO 2 R 9 , (12) —SO 2 —NR 10 R 11 , (13) —NR 10 R 11 , (14) —CONR 10 R 11 , and (15) —NO 2 , or two of R 2a , R 2b and R 2c are linked to form a group wherein r is 1 to 3; R 3 is selected from the group consisting of: (1) C 1-6 alkyl, which is substituted with heterocycle, which is substituted with R 2a , R 2b and R 2c , and (2) heterocycle, which is substituted with R 2a , R 2b and R 2c ; R 4 and R 5 are independently selected from the group consisting of: (1) hydrogen, and (2) C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, or R 4 and R 5 taken together form a C 3-6 cycloalkyl ring; A is selected from the group consisting of: (1) —O—, and (2) —NR 10 —; m is zero or one, whereby when m is zero R 2 is attached directly to the carbonyl; and pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof.