Patent ID: 7217718

Claim:
A method of inhibiting rejection of a transplanted organ, tissue or cell in a recipient mammal, the method comprising the step of administering to the recipient mammal an effective amount of anti-CD40L monoclonal antibody or rapamycin and an effective amount of a compound represented by the following structural formula: or a physiological salt thereof, wherein: R 1 is a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group or a substituted or unsubstituted alkyl group; R 2 is an optionally substituted alkyl group or an alkyl group substituted with —NR 5 R 6 ; R 3 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; R 4 a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; and R 5 and R 6 are independently selected from a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group or R 5 and R 6 taken together with the nitrogen to which they are attached are a non-aromatic heterocyclic group; wherein each substituted aryl group, substituted alkyl group or substituted aralkyl group are independently optionally substituted at a carbon atom with —OH, —Br, —Cl, —I, —F, R, —CH 2 R, —OCH 2 R, —CH 2 OC(O)R, —OR, —O—COR, —COR, —CN, —NO 2 , —COOH, —SO 3 H, —NH 2 , —NHR, —N(R) 2 , —COOR, —CHO, —CONH 2 , —CONHR, —CON(R) 2 , —NHCOR, —NRCOR, —NHCONH 2 , —NHCONRH, —NHCON(R) 2 , —NRCONH 2 , —NRCONRH, —NRCON(R) 2 , —C(═NH)—NH 2 , —C(═NH)—NHR, —C(═NH)—N(R) 2 , —C(═NR)—NH 2 , —C(═NR)—NHR, —C(═NR)—N(R) 2 , —NH—C(═NH)—NH 2 , —NH—C(═NH)—NHR, —NH—C(═NH)—N(R) 2 , —NH—C(═NR)—NH 2 , —NH—C(═NR)—NHR, —NH—C(═NR)—N(R) 2 , —NRH—C(═NH)—NH 2 , —NR—C(═NH)—NHR, —NR—C(═NH)—N(R) 2 , —NR—C(═NR)—NH 2 , —NR—C(═NR)—NHR, —NR—C(═NR)—N(R) 2 , —SO 2 NH 2 , —SO 2 NHR, —SO 2 NR 2 , —SH, —SO k R or —NH—C(═NH)—NH 2 ; wherein each substituted aryl group or substituted aralkyl group are independently optionally substituted at a nitrogen atom, if present, with —R′, —N(R′) 2 , C(O)R′, CO 2 R′, —C(O)C(O)R′, —C(O)CH 2 C(O)R′, —SO 2 R′, —SO 2 N(R′) 2 , —C(═S)N(R′) 2 , —C(═NH)—N(R′) 2 , or —NR′ SO 2 R′; R′ is hydrogen, an alkyl group, phenyl, —O(Ph), CH 2 (Ph), heteroaryl or non-aromatic heterocyclic ring; each R is independently an alkyl, benzyl, or aryl group; or —N(R) 2 , taken together, can also form a non-aromatic heterocyclic group; and k is 0, 1 or 2.