Patent ID: 8247570

Claim:
A method for preparing a compound of Formula 1 wherein R 1 is NHR 3 ; R 2 is CH 3 or Cl; and R 3 is H, C 1 -C 4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; comprising contacting (1) a compound of Formula 2 wherein X is Br or Cl; with (2) a metal cyanide reagent, (3) a copper(I) salt reagent, (4) an iodide salt reagent and (5) at least one compound of Formula 3 wherein each R 5 , R 6 , R 7 , R 8 and R 9 is independently H, C 1 -C 12 alkyl, C 1 -C 6 alkoxy or NR 10 R 11 ; and each R 10 and R 11 is independently H or C 1 -C 6 alkyl; or a pair of R 10 and R 11 attached to the same nitrogen are taken together as —CH 2 CH 2 CH 2—, —CH 2 CH 2 CH 2 CH 2 —, —CH 2 (CH 2 ) 3 CH 2 —, —CH 2 CH 2 OCH 2 CH 2 —, —CH 2 CH 2 N(R 16 )CH 2 CH 2 — or —CH 2 CH 2 S(O) n CH 2 CH 2 —, each optionally substituted with up to 4 substituents independently selected from C 1 -C 4 alkyl; each R 16 is independently H or C 1 -C 12 alkyl; and each n is independently 0, 1 or 2; provided that when X is Cl , then R 2 is methyl.