Patent ID: 8435511

Claim:
An isolated anti-hepsin antibody, wherein the antibody comprises (i) a variable heavy chain comprising (a) HVR-H1 comprising SEQ ID NO:4; (b) HVR-H2 comprising sequence SEQ ID NO:5; and (c) HVR-H3 comprising sequence SEQ ID NO:6 and (ii) a variable light chain comprising (a) HVR-L1 comprising sequence SEQ ID NO: 1; (b) HVR-L2 comprising sequence SEQ ID NO:2; and (c) HVR-L3 comprising sequence SEQ ID NO:3, wherein a monovalent form of the antibody binds human hepsin, wherein human hepsin comprises SEQ ID NO:47, with an affinity of less than or equal to 10 nM or better.