Patent ID: 7163817

Claim:
A chimeric polypeptide comprising the following components: (a) a streptokinase component capable of plasminogen activation; and (b) a fibrin-binding component, wherein said fibrin-binding component is fibrin-binding domains 4 and 5 of fibronection or is fibrin-binding domains 1 and 2 of fibronection; wherein said streptokinase component and said fibrin-binding component are fused via a peptide bond and are linked through a region that is sufficiently flexible so as to allow plasmin-dependent activation of the streptokinase component, wherein said chimeric polypeptide is encoded by a polynucleotide selected from the group consisting of SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12.