Patent ID: 7772257

Claim:
A compound of formula I: wherein R1 is selected from the group consisting of (C1-C6) alkyl, (C0-C6) alkylene (C3-C6) cycloalkyl, (C0-C6) alkylene-O—(C1-C6) alkyl, (C0-C6) alkylene-O—(C3-C6) cycloalkyl (C0-C6) alkylene-(C6-C14) aryl and (C0-C6) alkylene-(C5-C15) heteroaryl, wherein the alkyl, alkylene, aryl, heteroaryl and cycloalkyl can be unsubstituted or mono-, di- or tri-substituted by F, Cl, Br, OCF 3 , CN, CO—(C1-C6) alkyl, COO(C1-C6) alkyl, CON((C0-C6) alkylene-H)((C0-C6) alkylene-H), or S(O) m (C1-C6) alkyl; R2, R3, R4 and R5 are independently selected from the group consisting of H, halogen, (C1-C6) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, CN, COO(C1-C6) alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H) and S(O) m (C1-C6) alkyl, wherein the alkyl and alkylene are unsubstituted or mono-, di- or tri-substituted by F; A is (C4-C10) heteroaryl; n is 1, 2, or 3; m and z are independently 0, 1, or 2; and R6, R7 and R8 are independently selected from the group consisting of H, (C1-C6) alkyl, CN, CO—(C1-C6) alkyl, COO—(C1-C6) alkyl, CON((C0-C6) alkylene-H((C0-C6) alkylene-H), S(O) m (C1-C6) alkyl, N((C0-C6) alkylene-H)((C0-C6) alkylene-H), N((C0-C6) alkylene-H)—CO—(C1-C6) alkyl, N((C0-C6) alkylene-H)—CO—(C1-C6) alkyl, halogen, (C0-C6) alkylene-(C6-C14) aryl (C0-C6) alkylene-O—(C0-C6) alkylene-H, (C0-C6) alkylene-O—(C6-C14) aryl, SCF3, S(O)2CF3 and NO2, wherein the alkyl, aryl and alkylene are unsubstituted or mono-, di- or tri-substituted by F, and the aryl can also be unsubstituted or monosubstituted by CF3; or a stereoisomer, enantiomer, tautomer, or physiologically acceptable salt thereof.