Patent ID: 7759513

Claim:
A compound having the formula (1): wherein R 1 is selected from the group consisting of H, NO 2 , CN, OCH 3 , a halogen, an alkyl having up to 4 carbon atoms, and an alkoxyl having up to 4 carbon atoms; R 2 is selected from the group consisting of an aryl group, a substituted aryl group, a heteroaryl group, substituted heteroaryl group, an aroyl group, and a substituted aroyl group; R 3 is selected from the group consisting of H, NO 2 and a halogen; R 4 is selected from the group consisting of H, OCH 3 and an alkyl group having up to 4 carbon atoms; X is selected from the group consisting of oxygen and sulfur; and Z is selected from the group consisting of a leaving group, an alcoholate group, —OH, a N-atom of an amine compound, a deoxyribonucleoside and a ribonucleoside as represented by either of the following formulae (2) or (3): wherein R 5 is selected from the group consisting of a H, an oligonucleotide, a phosphoramidite group and a protecting group; R 6 is selected from the group consisting of H, OH , an alkoxyl having up to 4 carbon atoms, an alkenoxyl group having up to 4 carbon atoms, a substituted alkenoxyl group having up to 4 carbon atoms, or R 6 is WR 8 wherein W is selected from oxygen and sulfur and R 8 is a protective group useful in oligonucleotide synthesis; B is a base selected from the group consisting of adenine, cytosine, guanine, thymine, and uracil, and when B is any one of adenosine, cytosine and guanine the amino functions on the heterocycle may bear a protective group useful in oligonucleotide synthesis.