Patent ID: 7713514

Claim:
A biocompatible organized mobile multicomponent conjugate (OMMC) comprising: (A) a lamellar structure comprising CH 3 —(CH 2 ) e —X, wherein: (1) e ranges from 16 to 32 inclusive; and (2) X is selected from carboxylate, sulfonate, sulfate, phosphate, and phosphonate; and (B) a first binding compound and a second binding compound, each of which is anchored to the lamellar structure, the first binding compound capable of binding to an exogenous first affinity site, and the second binding compound capable of binding to an exogenous second affinity site, wherein the first and second binding compounds are mobile and self-adjust relative to the lamellar structure to allow for cooperative binding of the first and second binding compounds to said first and second affinity sites, respectively, wherein each binding compound independently comprises: (1) an anchor region that anchors the binding compound to the lamellar structure, the anchor region being selected from CH 3 (CH 2 ) a —W, CH 3 (CH 2 ) a —O—(CH 2 ) b —W, CH 3 (CH 2 ) a —S—(CH 2 ) b —W, R 1 O 2 CCH 2 (CHW)CO 2 R 1 , CF 3 (CH 2 ) a —W, CF 3 (CF 2 ) a —W, CF 3 (CF 2 ) a CH 2 CH 2 —W, CF 3 (CF 2 ) 2 —O—(CH 2 ) b —W, and CH 3 (CH 2 ) a —S—S—(CH 2 ) b —W, wherein: (a) each of a and b ranges from 16 to 32, inclusive; (b) W is selected from —O—, —CO—, —CO 2 —, —OCO—, —O 2 CO—, —S—, —SO—, —SO 2 —, —NH—, —NHCO—, —NHCS—, —NHSO 2 —, —PO 2 H—, —OPO 2 H—, —PO 2 —, and —OPO 2 —; and (c) R 1 is an alkyl radical containing 16 to 24 carbon atoms; and (2) a binding region selected from amino acids, peptides, peptidomimics, monosaccharides, disaccharides, oligosaccharides, sialic acid, carminic acid, and anionic compounds of —(CH 2 ) d —CO 2 − , —(CH 2 ) d —SO 3 − , —(CH 2 ) d —OSO 3 − , —(CH 2 ) d —PO 3 = , —(CH 2 ) d —OPO 3 = , —Ar—SO 3 − , DTPA, EDTA, DOTA, and EGTA, wherein d ranges from 1 to 10, inclusive; and (3) a linker that connects the anchor region to the binding region, the linker being selected from polysorbates, polyglycerols, polypeptides, polynucleotides, polysaccharides, polyvinylpyrrolidones, polyvinylalcohols, polyethyleneglycols, polyglycolate, polylactate, and copolymers of any of the members of this group.