Patent ID: 8067412

Claim:
A compound of formula 1, tautomers thereof, or a pharmaceutically acceptable salt, solvate, or ester thereof: wherein: R 1 , R 2 , R 3 , R 4 and R 5 are independently hydrogen, halogen, nitro, cyano, alkyl, substituted alkyl, alkenyl, alkynyl, alkylaryl, aralkyl, aryl, heteroalkyl, alkylheteroaryl, heterocyclyl, heteroaryl, OH, OR, NH 2 , N(R) 2 , SR, S(O)R, S(O) 2 R, —SO 2 N(R) 2 , —N(R)SO 2 R, —N(CO)R, —N(CO)N(R) 2 , —N(CO)OR, —O(CO)R, —(CO)R, —(CO)OR, —(CO)N(R) 2 , —O(CO)OR, or —O(CO)N(R) 2 , wherein each R can be the same or different; when B 1 and B 2 together are —CH 2 —CH 2 —, then A 1 and A 2 together are —CH 2 —CH 2 —, or —CH═CH—; or when B 1 and B 2 together represent a covalent bond, then A 1 and A 2 together are —CH 2 —CH 2 —, —CH═CH—, —CH(OH)—CH(OH)—, —CH(OH)—CH(halogen)- , —CH(halogen)-CH(OH)—, 1,2-cyclopropadiyl; X 1 is hydrogen, halogen, OH, OR, NH 2 , N(R) 2 , NH—OR, SR, S(O)R, S(O) 2 R, —NH—O—(CH 2 ) n —CO 2 —R, —NH—O—(CH 2 ) n —CON(R) 2 ; or X 1 together with X 2 or X 3 represents a covalent bond, wherein each R can be the same or different; X 2 and X 3 are both hydrogen, or one of X 2 and X 3 is hydrogen and the other together with X 1 represents a covalent bond; X 4 and X 5 together are ═N—OR, ═N—O—(CH 2 ) n COOR, ═N—O—(CH 2 ) n CON(R) 2 , =N—N(R) 2 , ═N—N—SOR or ═N—N—SO 2 R; or one of X 4 and X 5 is hydrogen and the other is OH, OR, O(CO)R, O(CO)OR, O(CO)N(R) 2 , —(CH 2 ) n C(O)OR, or —(CH 2 )C(O)N(R) 2 , and n is 0, 1, 2, or 3; or one of X 4 and X 5 together with X 6 represents a covalent bond and the other of X 4 and X 5 is OH, OR, O(CO)R, O(CO)OR, —N(R) 2 or O(CO)N(R) 2 , wherein each R can be the same or different; X 6 is hydrogen or X 6 together with one of X 4 and X 5 represents a covalent bond; and R is hydrogen, alkyl, acyl, aryl, alkaryl, arylalkyl including benzyl, heteroalkyl, heteroaryl, heterocyclyl, a protecting group; or two R on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclic or heteroaryl ring; and n is 0, 1, 2 or 3.