Patent ID: 8507685

Claim:
A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof, wherein: represents a single bond or a double bond A is substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 5-8 cycloalkyl, substituted or unsubstituted C 5-8 cycloalkenyl or hydrogen; R 1 is O, S, NH, CH or CH 2 ; R 2 is hydrogen, halogen, —OC 1-3 alkyl, substituted or unsubstituted C 1-3 alkyl, CN, C(O)R 7 , NR 8 R 9 or hydroxyl; R 3 is hydrogen, halogen, —OC 1-3 alkyl, substituted or unsubstituted C 1-3 alkyl, CN, C(O)R 7 , NR 8 R 9 or hydroxyl; R 4 is OPO 3 H 2 , carboxylic acid, PO 3 H 2 , substituted or unsubstituted C 1-6 alkyl, —S(O) 2 H, —P(O)MeOH, —P(O)(H)OH or OR 10 ; R 5 is hydrogen, halogen, —OC 1-3 alkyl, substituted or unsubstituted C 1-3 alkyl, CN, C(O)R 7 , NR 8 R 9 or hydroxyl; R 6 is hydrogen, halogen, —OC 1-3 alkyl, substituted or unsubstituted C 1-3 alkyl, CN, C(O)R 7 , NR 8 R 9 or hydroxyl; R 7 is hydrogen, OR 10 or substituted or unsubstituted C 1-3 alkyl; R 8 is hydrogen or substituted or unsubstituted C 1-3 alkyl; R 9 is hydrogen or substituted or unsubstituted C 1-3 alkyl; R 10 is hydrogen or substituted or unsubstituted C 1-3 alkyl; L 1 is O, S, NH or CH 2 ; L 2 is O, S, NH, a direct bond or CH 2 ; a is 0 or 1; b is 0, 1, 2 or 3; c is 1, 2 or 3; and d is 1, 2 or 3; with the provisos when a is 1 then represents and when a is 0 then R 1 is O, S, NH, or CH 2 .