Patent ID: 8450334

Claim:
A method for substantially impairing cancer progression or metastasis in a subject known to have, or suspected of being at risk for having, prostate cancer, ovarian carcinoma, endometrial cancer or renal cell carcinoma, comprising: administering to the subject a therapeutically effective amount of a hepsin inhibitor that comprises at least one compound that is selected from a compound of formula (IV) and a compound of formula (V): wherein: each n is 1, 2, 3, 4 or 5; each r is 1, 2, 3 or 4; q is 1, 2, 3, 4, 5 or 6; each R 1a and R 1b is independently selected from the group consisting of hydrogen, alkyl, halo, haloalkyl, optionally substituted aryl, optionally substituted aralkyl, —OR 7 , —CN, —C(O)R 7 , —C(O)OR 7 , —C(O)N(R 7 )R 8 , —NO 2 , —N(R 7 )R 8 , —N(R 7 )C(O)R 8 , and —N(R 7 )C(O)OR 8 ; each R 2 is independently selected from the group consisting of hydrogen, alkyl, halo, haloalkyl, optionally substituted aryl and optionally substituted aralkyl; each R 3 and R 4 is independently selected from the group consisting of hydrogen, alkyl, optionally substituted aryl and optionally substituted aralkyl; and each R 7 and R 8 is independently selected from the group consisting of hydrogen, alkyl, optionally substituted aryl and optionally substituted aralkyl; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof