Patent ID: 6921544

Claim:
A method for the preparation of biocompatible phase-pure crystalline magnesium-substituted hydroxyapatite comprising mechanochemically comminuting and dissolving while hydrothermally reacting without external heating a source of calcium ions, a source of magnesium ions, a source of phosphate ions and a source of hydroxide ions, at least one of which is soluble in water, in a aqueous reaction medium until said magnesium substituted-hydroxyapatite is formed, wherein at least one of said source of calcium ions, source of magnesium ions, source of phosphate ions and source of hydroxide ions is water-insoluble or forms a water-insoluble apatite precursor, and said ion sources are stoichiometrically selected to provide a level of magnesium substitution in the hydroxyapatite lattice structure between about 2.0 and about 29 wt %.