Patent ID: 7645886

Claim:
A method for the manufacture of a compound of formula II defined below, comprising a method for the manufacture of amides of the formula II, wherein n is a number from 0 to 4, each R 1 is, independently of the other substituents R 1 , unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocyclyl, alkylsulfonyl, sulfonyl alkyl, N-mono- or N,N-disubstituted or unsubstituted aminosulfonyl alkyl, hydroxy, mercapto, nitro, halogen, cyano, carboxamido, N-mono- or N,N-disubstituted carboxamido, carboxhydrazido, unsubstituted or substituted alkoxycarbonyl, unsubstituted or subsituted alkoxy, formyl or other alkanoyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, alkanoyloxy, N-mono- or N,N-disubstituted or unsubstituted amino, unsubstituted or substituted hydrazino, or is a residue of a boronic acid or an ester thereof; R2 is hydrogen or unsubstituted or substituted alkyl, unsubstituted or substituted alkoxycarbonyl, unsubstituted or substituted arylsulfonyl, unsubstituted or substituted alkylsulfonyl, unsubstituted or substituted aryl, carbamoyl or N-mono- or N,N-disubstituted carbamoyl, silyl substituted by three moieties independently selected from unsubstituted or substituted alkyl and substituted or unsubstituted aryl, or acyl, and R3 and R4 are, independently of each other, unsubstituted or substituted alkyl or together form an unsubstituted or substituted alkylene bridge (thus forming a ring with the binding nitrogen) or an alkylene bridge to which a phenyl or a C 3 -C 8 -cycloalkyl ring is condensed at two vicinal carbon atoms of the alkylene bridge where a starting material of the formula III, wherein n, R 1 and R2 have the meanings given under formula II and NB is a tertiary nitrogen base where the nitrogen is not part of a ring, is reacted (b) with an active amido carbonic acid derivative of the formula V, wherein X is halogen and R3 and R4 are as defined under formula II, to give the corresponding compound of the formula II.