Patent ID: 8222272

Claim:
A pharmaceutical formulation comprising: a. a solid dispersion of a macrolide compound of formula (I); and b. a non-dispersed, non-dissolved, crystalline form of the macrolide compound; wherein the amount of the solid dispersion of the macrolide compound is from about 50% to about 85% of the combined amount of the solid dispersion and the non-dispersed, non-dissolved crystalline form, wherein the combined amount equals 100% of a pharmaceutically acceptable amount, wherein the compound of formula (I) is represented by the following: wherein each vicinal pair of R 1 and R 2 , R 3 and R 4 , R 5 and R 6 independently may, a) represent two vicinal hydrogen atoms, or b) form a second bond between the vicinal carbon atoms to which they are attached; in addition to the meanings above, R 2 may represent an alkyl group; R 7 represents hydrogen, hydroxy group, protected hydroxy or alkyloxy group or, in conjunction with R 1 , it may represent oxo group; R 8 and R 9 independently represent hydrogen or hydroxy group; R 10 represents hydrogen, alkyl group, alkyl group substituted by one or more hydroxy groups, alkenyl group, alkenyl group substituted by one or more hydroxy groups, or alkyl group substituted by oxo group; X represents oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom) or —CH 2 O—; Y represents oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom) or N—NR 11 R 12 or N—OR 13 ; R 11 and R 12 independently represent hydrogen atom, or alkyl, aryl or tosyl group; R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 22 and R 23 independently represent hydrogen atom or alkyl group; R 20 and R 21 independently represent oxo group, or they may independently represent (R 20 a , hydrogen atom) and (R 21 a , hydrogen atom) respectively; R 20 a and R 21 a independently represent hydroxy group, alkyloxy group, or OCH 2 OCH 2 CH 2 OCH 3 or R 21 a is protected hydroxy group; in addition R 20 a and R 21 a may together represent an oxygen atom in an epoxide ring; n is 1, 2 or 3; in addition to the meanings above, Y, R 10 and R 23 , together with the carbon atoms to which they are attached, may represent a 5- or 6-membered N- , S- and/or O-containing heterocyclic ring, which may be saturated or unsaturated, and which may be substituted by one or more groups selected from alkyl group, hydroxy group, alkyl group substituted by one or more hydroxy groups, alkyloxy group, benzyl and —CH 2 Se(C 6 H 5 ).