Patent ID: 7119064

Claim:
A method of modulating an intracellular signaling molecule in a cell, the method comprising contacting the cell with an effective amount of a modulator selected from the group consisting of colostrinin, a constituent peptide of colostrinin, and combinations thereof, under conditions effective to accomplish at least one of the following: reduce 4-hydroxynonenal (4HNE)-protein adduct formation; inhibit 4HNE-mediated glutathione depletion; inhibit 4HNE-induced activation of p53 protein; or inhibit 4HNE-induced activation of c-Jun NH2-tenninal kinases; wherein the constituent peptide of colostrinin is selected from the group consisting of MQPPPLP (SEQ ID NO:1) LQTPQPLLQVMMEPQGD (SEQ ID NO:2), DQPPDVEKPDLQPFQVQS (SEQ ID NO:3), LFFFLPVVNVLP (SEQ ID NO:4), DLEMPVLPVEPFPFV (SEQ ID NO:5), MPQNFYKLPQM (SEQ ID NO:6), VLEMKFPPPPQETVT (SEQ ID NO:7), and LKPFPLKVEVFPFP (SEQ ID NO:8).