Patent ID: 8318742

Claim:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid or base addition salt thereof, wherein R 1 and R 2 taken together form a bivalent radical of formula —O—CH 2 —O— (a-1) —O—CH 2 —CH 2 —O— (a-3) —O—CH 2 —CH 2 —CH 2 —O— (a-5) wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C 1-6 alkyl, R 3 is hydrogen or halo; R 4 is hydrogen or C 1-6 alkyl; R 5 is hydrogen or C 1-6 alkyl; L is C 3-6 cycloalkyl, C 5-6 cycloalkanone, or C 2-6 alkenyl, or L is a radical of formula -Alk-R 6 (b-1), -Alk-X—R 7 (b-2), -Alk-Y—C(═O)—R 9 (b-3), or -Alk-Y—C(═O)—NR 11 R 12 (b-4), wherein each Alk is C 1-12 alkanediyl; and R 6 is hydrogen, hydroxy, cyano, C 1-6 alkylsulfonylamino, C 3-6 cycloalkyl, C 5-6 cycloalkanone, or Het 1 ; R 7 is hydrogen, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 3-6 cycloalkyl, or Het 2 ; X is O, S, SO 2 or NR 8 ; wherein said R 8 is hydrogen or C 1-6 alkyl; R 9 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxy or hydroxy; Y is NR 10 or a direct bond; said R 10 being hydrogen or C 1-6 alkyl; R 11 and R 12 each independently are hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or R 11 and R 12 combined with the nitrogen atom bearing R 11 and R 12 may form a pyrrolidinyl or piperidinyl ring both being optionally substituted with C 1-6 alkyl, amino or mono or di(C 1-6 alkyl)amino, or said R 11 and R 12 combined with the nitrogen bearing R 11 and R 12 may form a piperazinyl or 4-morpholinyl radical both being optionally substituted with C 1-6 alkyl; and Het 1 and Het 2 each independently are furan; furan substituted with C 1-6 alkyl or halo; tetrahydrofuran; a tetrahydrofuran substituted with C 1-6 alkyl; a dioxolane; a dioxolane substituted with C 1-6 alkyl, a dioxane; a dioxane substituted with C 1-6 alkyl; tetrahydropyran; a tetrahydropyran substituted with C 1-6 alkyl; pyrrolidinyl; pyrrolidinyl substituted with one or two substituents that is each independently halo, hydroxy, cyano, or C 1-6 alkyl; pyridinyl; pyridinyl substituted with one or two substituents that is each independently halo, hydroxy, cyano, C 1-6 alkyl; pyrimidinyl; pyrimidinyl substituted with one or two substituents that is each independently halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkyloxy, amino or mono and di(C 1-6 alkyl)amino; pyridazinyl; pyridazinyl substituted with one or two substituents that is each independently hydroxy, C 1-6 alkyloxy, C 1-6 alkyl or halo; pyrazinyl; pyrazinyl substituted with one ore two substituents that is each independently halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkyloxy, amino, mono- and di(C 1-6 alkyl)amino or C 1-6 alkyloxycarbonyl; Het 1 can also be a radical of formula Het 1 and Het 2 each independently are radicals of formula R 13 and R 14 each independently are hydrogen or C 1-4 alkyl.