Patent ID: 8592594

Claim:
A compound of formula (I) wherein A 1 is absent or —CH 2 —; A 2 is nitrogen or —CH—; A 3 is absent or —C(CH 3 ) 2 —; R 1 is hydroxyl or NR 11 R 12 ; R 2 and R 3 are each independently selected from the group consisting of alkyl, alkenyl and phenyl; or R 2 and R 3 together with the carbon atom to which they are attached form cycloalkyl; R 4 , R 5 , R 6 , R 7 and R 8 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, alkylsulfonyl, morpholinyl, piperazinyl and alkylpiperazinyl; R 9 is selected from the group consisting of hydrogen, alkyl, benzyl and alkylaminocarbonyl; R 10 is hydrogen or halogen; and R 11 and R 12 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, hydroxyalkyl, oxetanyl, alkylpiperidinyl, 1,1-dioxothiomorpholinylalkyl and benzylpiperidinyl; or R 11 and R 12 together with the nitrogen atom to which they are attached form morpholinyl, piperazinyl, alkylpiperazinyl, alkylsulfonylpiperazinyl, alkylhydroxypyrrolidinyl or hydroxyalkylpyrrolidinyl; or a pharmaceutically acceptable salt or ester thereof.