Patent ID: 8735344

Claim:
A composition comprising: an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide in a form suitable for delivery into a blood vessel; and a bioactive attached to a spatially distinct hydrophobic or charged domain of the mimetic peptide wherein the bioactive comprises at least one of a statin; nitroglycerin; an Acyl CoA cholesterol:acyltransferase (ACAT) inhibitor; an anti-inflammatory steroid; a singlet oxygen generator; a phthalocyanine; a porphyrin; a sub-class of a porphyrin; or an immunosuppressant wherein the Apo A-I synthetic mimetic peptide is selected from the group consisting of: (SEQ ID NO: 1) (i) An 18 amino acid peptide, DWFKAFYDKVAEKFKEAF; (SEQ ID NO: 2) (ii) An 18 amino acid peptide, DWLKAFYDKVAEKLKEAF; (SEQ ID NO: 3) (iii) A 33 amino acid peptide, PALEDLRQGLLPVLESFKV FLSALEEYTKKLNTQ; (SEQ ID NO: 4) (iv) Ac-DWFKAFYDKVAEKFKEAF-NH 2 ; (SEQ ID NO: 5) (v) Ac-PALEDLRQGLLPVLESFKVFLSALEEYTKKNTQ-NH 2 ; (SEQ ID NO: 6) (vi) Ac-FAEKFKEAVKDYFAKFWD-NH 2 ; (SEQ ID NO: 7) (vii) Ac-FAEKLKEAVKDYFAKLWD-NH 2 ; (SEQ ID NO: 8) (viii) Ac-NLKKTYEELASLFSVKFSELVPLLGQRLDELAP-NH 2 ; (SEQ ID NO: 9) (ix) Ac-LKLLDNWDSVTSTFSKLREQLGPALEDLRQGLL-NH 2 ; and (SEQ ID NO: 10) (x) Ac-PALEDLRQGLLPKLLDNWDSVTSTFSKLREQLG-NH 2 .