Patent ID: 8653270

Claim:
A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and tautomers or a pharmaceutically acceptable salt thereof, wherein: R 1 is N or C—R 9 ; R 2 is substituted or unsubstituted heterocycle, C 5-8 cycloalkenyl or C 6-10 aryl; R 3 is O, N—R 10 , CH—R 11 , S, —CR 12 ═CR 13 —, —C≡C— or —C(O)—; R 4 is H, C 5-8 cycloalkenyl, C 3-8 cycloalkyl or substituted or unsubstituted C 6-10 aryl; R 5 is H, halogen, —OC 1-3 alkyl, C 1-3 alkyl or hydroxyl; R 6 is H, halogen, —OC 1-3 alkyl, C 1-3 alkyl or hydroxyl; a is 0, 1, 2, 3 or 4; b is 0, 1, 2, 3 or 4; L is CHR 7 , O, S, NR 8 or —C(O)—; R 7 is H, C 1-3 alkyl, —OC 1-3 alkyl, halogen, hydroxyl or NR 9 R 10 ; R 8 is H or C 1-3 alkyl; R 9 is H, halogen or C 1-3 alkyl; R 10 is H or C 1-3 alkyl; R 11 is H or C 1-3 alkyl; R 12 is H or C 1-3 alkyl; R 13 is H or C 1-3 alkyl; Q 1 is —CR 14 R 15 —; R 14 is H, halogen, or C 1-3 alkyl; R 15 is H, halogen, or C 1-3 alkyl; m is 0, 1, 2 or 3; T is —NH-Q 2 , “*” represents the point of attachment to the rest of the molecule; R 18 is NR 9 , O, or S; Q 2 is the same or independently —OPO 3 H 2 , carboxylic acid, —PO 3 H 2 , —S(O) 2 OH, —P(O)MeOH, —P(O)(H)OH, —OH with the proviso that when R 3 is O, N—R 10 , S, —CR 12 ═CR 13 —, —C≡C— or —C(O)— and b is 0 or 1 then L is not O, S, NR 8 or —C(O)—.