Patent ID: 8158798

Claim:
A process for preparing a substituted quinolone according to Formula I: wherein: R 1 is C 1 -C 4 alkyl; R 2 is C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl; R 4 and R 5 are each independently selected from a group consisting of amino, C 1 -C 4 alkylamino, protected amino, and C 1 -C 4 alkyl; and n is 1 or 2; said process comprising: the step of reacting a compound of Formula II with compound of Formula III in the presence of a suitable base at about 20° C. to about 80° C., followed by hydrolysis: wherein R 3 is unsubstituted or substituted C 1 -C 4 acyloxy; and R 1 , R 2 , R 4 , R 5 , and n are as defined for Formula I above.