Patent ID: 7345062

Claim:
A pharmaceutical composition comprising: (a) a compound of the formula: or an acid addition salts thereof, wherein the carbon atom designated * constitutes a center of chirality, R 4 hydrogen or —(C═O)—R 12 ; each of R 1 and R 12 , independently of each other, is alkyl of 1 to 6 carbon atoms, phenyl, benzyl, pyridyl methyl, pyridyl, imidazoyl, imidazolylmethyl, or CHR*(CH 2 ) n NR*R 0 wherein R* and R 0 , independently of the other, are hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, benzyl, pyridylmethyl, pyridyl, imidazoyl or imidazolylmethyl, and n=0, 1, 2; R 5 is C═O, CH 2 , —CH 2 —CO—, or SO 2 ; each of R 6 and R 7 , independently of the other, is nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, cycloalkoxy of 3 to 8 carbon atoms, halo, bicycloalkyl of up to 18 carbon atoms, tricycloalkoxy of up to 18 carbon atoms, 1-indanyloxy, 2-indanyloxy, C 4 -C 8 -cycloalkylidenemethyl, or C 3 -C 10 -alkylidenemethyl; and each of R 8 , R 9 , R 10 , and R 11 independently of the others, is (i) hydrogen, nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkylamino, dialkylamino, acylamino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, halo, or (ii) one of R 8 , R 9 , R 10 , and R 11 is acylamino comprising a lower alkyl, and the remaining of R 8 , R 9 , R 10 , and R 11 are hydrogen, or (iii) hydrogen if R 8 and R 9 taken together are benzo, quinoline, quinoxaline, benzimidazole, benzodioxole, 2-hydroxybenzimidazole, methylenedioxy, dialkoxy, or dialkyl, or (iv) hydrogen if R 10 and R 11 , taken together are benzo, quinoline, quinoxaline, benzimidazole, benzodioxole, 2-hydroxybenzimidazole, methylenedioxy, dialkoxy, or dialkyl, or (v) hydrogen if R 9 and R 10 together are benzo; and (b) a pharmaceutically acceptable carrier.