Patent ID: 8546114

Claim:
A compound of Formula 1A, which is enriched in the R configuration and has an optical purity of at least 95% enantiomeric excess, wherein X 1 is H or a protective group for a hydroxy group selected from the group consisting of methoxymethyl, methoxythiomethyl, 2-methoxyethoxymethyl, bis(2-chloroethoxy)methyl, tetrahydropyranyl, tetrahydrothiopyranyl, 4-methoxytetrahydropyranyl, 4-methoxytetrahydrothiopyranyl, tetrahydrofuranyl, tetrahydrothiofuranyl, 1-ethoxyethyl, 1-methyl-1-methoxyethyl, triphenylmethyl, allyl, benzyl, substituted benzyl, and SiR a R b R c wherein R a , R b and R c are each independently C 1-4 alkyl, phenyl, benzyl, substituted phenyl, or substituted benzyl; and R 1 is (a) aryl or aralkyl, each of which is unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, alkyl, aryl, alkoxyl, aryloxy, thioalkoxyl, thioaryloxy, alkylamino, arylamino, cyano, alkoxycarbonyl, arylcarbonyl, arylaminocarbonyl, alkylaminocarbonyl, pyridinyl, thiophenyl, furanyl, imidazolyl, morpholinyl, oxazolinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, and pyrrolidinonyl, or (b) menthyl or an unsubstituted C 3 -C 10 cycloalkyl.