Patent ID: 7883848

Claim:
A method of detecting functional interactions between at least two molecules of interest, the method comprising: a. forming a plurality of interactors by coupling each molecule of interest with at least one nucleic acid moiety, the nucleic acid moiety comprising an identification sequence element and an association element; b. forming a plurality of cis-reactive cells wherein a cis-reactive cell comprises at least two interactors bound in proximity to one another by an associated oligonucleotide formed from the association between at least two nucleic acid moieties, wherein the associated oligonucleotide comprises at least two identification elements derived from the at least two nucleic acid moieties; c. subjecting the plurality of cis-reactive cells to conditions which stimulate a desired functional interaction having a detectable trace; d. selecting all cis-reactive cells exhibiting the detectable trace; and e. subjecting the associated oligonucleotides from the cis-reactive cells selected in step (d) to an analysis that permits detection of the at least two identification sequence elements.