Patent ID: 7745591

Claim:
An oligonucleotide containing at least one internucleotide linkage having the structure of formula (VIII) wherein: R 1 is hydrogen, a protecting group removable by an elimination reaction, hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl or substituted heteroatom-containing hydrocarbyl; X is O, S, NH or NR 7 wherein R 7 is hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl or substituted heteroatom-containing hydrocarbyl; n is zero or 1; Y is —(Y′) m —(CR 8 R 9 )— wherein m is zero or 1, Y′ is hydrocarbylene, substituted hydrocarbylene, heteroatom-containing hydrocarbylene, or substituted heteroatom-containing hydrocarbylene, wherein R 8 and R 9 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl and substituted heteroatom-containing hydrocarbyl; and Z is O, S, NH or NR 10 wherein R 10 is as defined for R 7 , wherein in any substituted hydrocarbyl, substituted heteroatom-containing hydrocarbyl, substituted hydrocarbylene, and substituted heteroatom-containing hydrocarbylene at least one hydrogen atom bound to a carbon atom is replaced by at least one of the following: hydroxyl, alkoxy, thio, thioester, halo, amino, nitrile, nitro, sulfonyl, phosphoro, carboxyl and thienyl.