Patent ID: 7482468

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein: n is 2, 3, 4 or 5; R is a 5- or 6-membered heteroaryl or heterocycloalkyl group, wherein one ring atom of the R group is nitrogen and the remaining ring atoms are carbon, and wherein the R group is optionally substituted with R 3 ; R 1 and R 2 together with the carbon atoms to which they are attached form X is —O—, —S— or —NR 7 —; Z is p is 1-3; q is 1-4 and r is 1-4, provided that the sum of q and r is 3-6; s is 1; R 3 is 1-3 substituents independently selected from the group consisting of H, alkyl, halo, —OH, alkoxy and —NR 11 R 12 ; R 6 is 1-3 substituents independently selected from the group consisting of H, alkyl, —CF 3 , halo, —NO 2 , —CN, —C(O)OR 13 , —C(O)NR 11 R 12 , —NR 14 R 15 , —OR 13 and haloalkyl; R 7 is H, alkyl, —C(O)OR 13 , —C(O)NR 11 R 12 or —C(O)R 13 ; each R 8 is independently selected from the group consisting of H, alkyl, cycloalkyl, R 3 -aryl, R 3 -arylalkyl, R 3 -heteroaryl, heterocycloalkyl, -alkyl-heteroalkyl, -alkyl-heteroaryl, —OR 13 , —C(O)OR 13 , —NR 14 R 15 , —C(O)NR 11 R 12 , —C(O)R 16 , C(═NOR 13 )aryl and —C(═NOR 13 )heteroaryl, wherein the heteroaryl moiety of an -alkyl-heteroaryl group is substituted with R 3 ; or two R 8 groups on the same carbon form a methylenedioxy or ethylenedioxy ring; R 11 and R 12 are independently selected from the group consisting of H, alkyl, cycloalkyl, aryl and arylalkyl; R 13 is H, alkyl, cycloalkyl or arylalkyl; R 14 is H, alkyl, cycloalkyl or arylalkyl; R 15 is H, alkyl, cycloalkyl, —C(O)OR 13 , —C(O)NR 11 R 12 or —C(O)R 13 ; R 16 is H, alkyl, R 3 -cycloalkyl, R 3 -aryl, R 3 -arylalkyl or R 3 -heteroaryl; each R 17 is independently selected from the group consisting of H, alkyl, cycloalkyl, R 3 -aryl, R 3 -arylalkyl, —C(O)OR 13 , —C(O)NR 11 R 12 and —C(O)R 16 ; a heteroaryl group is defined as a 2- to 14-membered carbocyclic group having from 1 to 4 of it's ring carbon atoms independently replaced with an oxygen, nitrogen or sulfur atom such that the heteroaryl group does not have adjacent oxygen and/or sulfur ring atoms, and wherein all available carbon and nitrogen ring atoms can be substituted as defined above; and a heterocycloalkyl group is defined as a 3- to 15 -membered carbocyclic group having from 1 to 3 of it's ring carbon atoms independently replaced with —O—, —S—, —S(O)—, —S(O) 2 — or N(R 40 )—, wherein R 40 is H, C 1 -C 6 alkyl or arylalkyl.