Patent ID: 7297836

Claim:
A method for detecting an amyloid peptide-related neurological disorder in a transgenic mouse model of the disorder, the method comprising: detecting a level of a calcium-responsive gene product in hippocampal tissue of the transgenic mouse model, wherein the calcium-responsive gene product is selected from a calbindin polypeptide, a neuropeptide Y polypeptide, an α-actinin II polypeptide, a Fos polypeptide, an Arc polypeptide, a phospho-ERK polypeptide, a calbindin mRNA, a neuropeptide Y mRNA, an α-actinin II mRNA, and a Fos mRNA, an Arc mRNA, and an ERK mRNA, and wherein the genome of said transgenic mouse comprises a transgene encoding a mutant amyloid precursor protein; wherein detection of a level of calcium-responsive gene product in the hippocampal tissue that differs from a level of the calcium-responsive gene product associated with a normal control mouse is indicative of an amyloid peptide-related neurological disorder in the mouse.