Patent ID: 8754107

Claim:
A compound of formula I or a stereoisomer thereof, or a pharmaceutically acceptable salt of the compound or stereoisomer, wherein X is optionally substituted with one or more substituents selected from the group consisting of (C 1 -C 5 )alkyl, —O(C 1 -C 3 )alkyl, CN, Cl, F, CF 3 and OH; D is C(R 5 ) 2 ; E is C(R 5 ) 2 ; W is C(R 4 ); M is a bond or C(O); or M is selected from the optionally substituted group consisting of —(C 1 -C 4 )alkyl, —C(O)N(R 2 ), —N(R 2 )C(O), —N(R 2 ), -aryl, -heterocyclyl and -heteroaryl; or M is selected from the optionally substituted group consisting of —(C 1 -C 4 )alkyl-heterocyclyl, —(C 1 -C 4 )alkyl-C(O), —(C 1 -C 4 )alkyl-C(O)N(R 2 ), —(C 1 -C 4 )alkyl-C(O)O, —(C 1 -C 4 )alkyl-N(R 2 )C(O)O, —(C 1 -C 4 ))alkyl-N(R 2 )C(O) and —CH 2 —NH—C(O) wherein the alkyl portion of the moiety is connected to W; T is H or is selected from the optionally substituted group consisting of indanyl, indenyl and phenyl; A is a bond or CH 2 ; G is NH, NH—CH 2 , or NH—C(O), wherein the N is attached to A; Q is H or is selected from the optionally substituted group consisting of (C 1 -C 5 )alkyl, (C 3 -C 7 )cycloalkyl, —O—(C 3 -C 7 )cycloalkyl and —(C 1 -C 3 )alkyl-O—(C 1 -C 3 )alkyl; R 1 is selected from the optionally substituted group consisting of 5,6,7,8-tetrahydro-[1,6]naphthyridinyl, phenyl, piperidinyl and quinazolinyl; R 2 is independently selected from the optionally substituted group consisting of H, (C 1 -C 4 )alkyl and (C 3 -C 5 )cycloalkyl; R 3 is independently H, OH, CN, F, CF 3 , C(O)N(R 2 ) 2 , N(R 2 ) 2 , or oxo; or R 3 is independently selected from the optionally substituted group consisting of (C 1 -C 3 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 3 )alkyl-O—(C 1 -C 3 )alkyl, —(C 1 -C 3 )alkyl-C(O)—O—(C 1 -C 3 )alkyl, aryl, -D-aryl, heteroaryl, heterocyclyl, —(C 1 -C 3 )alkyl-aryl, —N(R 2 )aryl, —O-aryl, —C(O)—O—(C 1 -C 3 )alkyl, —NH-phenyl and phenyl; R 4 is H, OH, CN or F or R 4 is selected from the optionally substituted group consisting of —O—(C 1 -C 3 )alkyl, —O—(C 3 -C 7 )cycloalkyl, aryl and heteroaryl; R 5 is H or CH 3 ; m and n are independently 0, 1, or 2; p is 1 or 2; x is 1 or 2; and y is 0, 1 or 2.