Patent ID: 7109204

Claim:
A compound of Formula I wherein R 1a is independently selected from: (1) H, (2) unsubstituted or substituted C 1 –C 10 alkyl, (3) OR 8 , and (4) N(R 8 ) 2 ; R 1 is independently selected from: (1) H, (2) unsubstituted or substituted C 1 –C 10 alkyl, (3) unsubstituted or substituted C 3 –C 10 cycloalkyl, (4) unsubstituted or substituted aryl, (5) unsubstituted or substituted heterocycle, (6) halo, (7) CF 3 , (8) —(CH 2 ) t R 9 C(O)R 8 , (9) —C(O)R 9 , (10) —(CH 2 ) t OR 8 , (11) unsubstituted or substituted C 2 –C 6 alkenyl, (12) unsubstituted or substituted C 2 –C 6 alkynyl, (13) CN, (14) —(CH 2 ) t NR 7 R 8 , (15) —(CH 2 ) t C(O)NR 7 R 8 , (16) —C(O)OR 8 , and (17) —(CH 2 ) t S(O) q (CH 2 ) t NR 7 R 8 ; R 2 is independently selected from: (1) H, (2) unsubstituted or substituted C 1 –C 10 alkyl, (3) unsubstituted or substituted C 3 –C 10 cycloalkyl, (4) unsubstituted or substituted aryl, (5) unsubstituted or substituted heterocycle, (6) halo, (7) CF 3 , (8) —(CH 2 ) t R 9 C(O)R 8 , (9) —C(O)R 9 , (10) —(CH 2 ) t OR 8 , (11) unsubstituted or substituted C 2 –C 6 alkenyl, (12) unsubstituted or substituted C 2 –C 6 alkynyl, (13) CN, (14) —(CH 2 ) t NR 7 R 8 , (15) —(CH 2 ) t C(O)NR 7 R 8 , (16) —C(O)OR 8 , and (17) —(CH 2 ) t S(O) q (CH 2 ) t NR 7 R 8 ; R 3 is independently selected from: (1) H, (2) unsubstituted or substituted C 1 –C 10 alkyl, (3) unsubstituted or substituted aralkyl, (4) CN, (5) halo, (6) N(R 8 ) 2 , (7) OR 8 , and (8) unsubstituted or substituted aryl; R 7 is selected from: (1) H, (2) unsubstituted or substituted C 1 –C 10 alkyl, and (3) unsubstituted or substituted aralkyl; R 8 is independently selected from: (1) H, (2) unsubstituted or substituted C 1 –C 10 alkyl, (3) unsubstituted or substituted aryl, (4) unsubstituted or substituted heterocycle, (5) unsubstituted or substituted C 3 –C 10 cycloalkyl, and (6) unsubstituted or substituted aralkyl; R 7 and R 8 , when attached to the same nitrogen atom may be joined to form a 5–7 membered heterocycle containing, in addition to the nitrogen, one or two more heteroatoms selected from N, O, or S, said heterocycle being optionally substituted with one to three R 2 substituents; R 9 is independently selected from: (1) unsubstituted or substituted C 1 –C 10 alkyl, (2) unsubstituted or substituted heterocycle, and (3) unsubstituted or substituted aryl; V is selected from: (1) a bond, (2) aryl, and (3) heterocycle; W is selected from: (1) aryl, and (2) heterocycle; m is 0, 1, or 2; n is independently 0, 1, 2, 3, 4, 5, or 6; p is 0, 1, 2, 3, or 4; q is independently 0, 1, or 2; t is independently 0, 1, 2, 3, 4, 5, or 6; or a pharmaceutically acceptable salt or stereoisomer thereof.