Patent ID: 8178334

Claim:
An isolated nucleic acid comprising a nucleic acid sequence which encodes a uricase selected from the group consisting of: a uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 12; a uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 13; a uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 12 further comprising an amino terminal amino acid, wherein the amino terminal amino acid is alanine, glycine, proline, serine, or threonine; and a uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 12 further comprising an amino terminal amino acid, wherein the amino terminal amino acid is methionine.