Patent ID: 8133885

Claim:
A compound according to formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is H or (1-4C)alkyl; R 2 is —C(O)R 15 or —S(O) 2 R 15 ; R 3 is H, (1-4C)alkyl or —OR 16 ; R 4 is H, (1-4C)alkyl or —OR 16 ; R 6 is H, —C(H)NOR 16 ; R 7 is H, halogen or cyano; or R 7 is (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl, all three optionally substituted with OH, halogen or NH 2 ; or R 7 is —C(H)NOR 16 , —OR 16 , —C(O)OR 16 or —C(O)R 16 ; R 8 is cyano; or R 8 is (1-6C) alkyl, (2-6C)alkenyl, (2-6C)alkynyl or —O(1-6C)alkyl, all substituted with amino, hydroxyl or halogen; or R 8 is (hetero)aryl, optionally substituted with cyano, halogen, (1-4C)alkyl, (1-4C)alkoxy or (1-4C)alkoxy(1-4C)alkyl; or R 8 is —C(H)NOR 16 , —C(O)NHR 17 , —C(O)R 18 , —C(O)OR 19 , or —C(1-4C)alkylNOR 21 ; R 9 is H, halogen, cyano or (1-4C)alkyl optionally substituted with halogen R 10 is H or (1-4C)alkyl; R 11 is H; R 12 is H, cyano or (1-4C)alkyl; R 13 is H, (1-4C)alkyl, halogen or formyl; R 14 is H, halogen, cyano, (1-4C)alkyl, (2-6C)alkenyl, C(O)R 21 or (hetero)aryl; R 15 is H; or R 15 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, —O(2-6C)alkyl, —O(2-6C)alkenyl or —O(2-6C)alkynyl, all optionally substituted with one or more OH, halogen, cyano or (hetero)aryl; or R 15 is (hetero)aryl, optionally substituted with (1-4C)alkyl, halogen, cyano, nitro or amino; or R 15 is NH 2 , (di)(1-4C)alkylamino, (1-4C)alkyl(1-4C)alkoxyamine, (1-4C)alkylthio(1-4C)alkyl or (1-4C)alkoxy(1-4C)alkyl; each R 16 independently is H, (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl; R 17 is H, (1-4C)alkoxy or (3-6C)cycloalkyl; or R 17 is (1-6C)alkyl, optionally substituted with halogen; or R 17 is (hetero)aryl, optionally substituted with halogen, (1-4C)alkyl or (1-4C)alkoxy; R 18 is H, NH 2 , —C(O)R 21 or —S(1-4C)alkyl; or R 18 is (1-4C)alkyl, optionally substituted with OH, halogen or cyano; R 19 is H or (1-6C)alkyl, optionally substituted with OH or halogen, and each R 21 independently is H or (1-6C)alkyl.