Patent ID: 8058414

Claim:
A compound having a structure of formula (I) or formula (II): wherein: B is a base selected from the group consisting of adenine, guanine, cytosine, uracil, thymine, or their respective analogs; L 1 is a group that forms a linkage between the base B and F; F is a heteroatom that forms a linkage between L 1 and L 2 ; L 2 is a chemically labile group with respect to its attachment to F and forms a chemical linkage to R 2 ; L 3 is a chemically labile group comprising a heteroatom and forms a chemical linkage to R 2 ; R 2 is a group comprising a reporter; R 1 is a group that suppresses the template directed polymerase incorporation rate of the nucleoside triphosphate onto the 3â€² end of an extending oligonucleotide prior to cleavage of L 2 -R 2 from the previous incorporation event; L 2 -R 2 prevents the template directed polymerase incorporation of the compound of the formula (I) onto the 3â€² end of an extending oligonucleotide onto which a compound of the formula (I) has been incorporated; 1 is an integer; and m=3lâˆ’1.