Patent ID: 7205418

Claim:
A process for preparing the compound of formula (I) as shown in Scheme 2, characterized in that it comprises the following steps of: (a) reacting an epoxide compound of formula (III) with vinyl magnesium bromide or vinyl magnesium chloride to produce a β-hydroxy compound of formula (IV); (b) protecting the hydroxy group of β-hydroxy compound of formula (IV) with an alkyloxy carbonyl group by reacting the β-hydroxy compound of formula (IV) with dialkyldicarbonate such as di-tert-butyl dicarbonate to produce a compound of formula (V); (c) cyclization-reacting the compound of formula (V) by a iodolactone forming reacting to produce a compound of formula (VI); (d) treating the compound of formula (VI) with a weak base such as K 2 CO 3 , Na 2 CO 3 to produce a compound of formula (II); (e) producing a 1,3-diol compound of formula (VII) by a ring opening reaction of the compound of formula (II) with various nucleophiles in the presence of a metal catalyst and a phase transition catalyst; (f) treating the 1,3-diol compound of formula (VII) with an acetylating agent or a ketalizing agent in the presence of an acid catalyst to transform the compound of formula (VII) into a compound of formula (VIII); and (g) if necessary, producing a compound of formula (I) by exchanging R′ 4 group in the compound of formula (VIII): wherein R 1 denotes a hydrogen atom, alkyl, aryl or alkylaryl, R 2 and R 3 which can be identical or different, denote a lower alkyl or phenyl and are capable of forming a six-membered ring, R 4 stands for hydroxy, amino, alkylamino, arylamino, azido, cyano, halogeno, aryloxy, alkyloxy, arylalkyloxy, alkyl, alkenyl, aryl, or aminomethyl, etc. and R′ 4 is the same as R 4 or a group of the precursor form.