Patent ID: 8765372

Claim:
A method for determining that a human subject is predisposed for developing an autoimmune disease, comprising: detecting in a sample isolated from said subject, the presence of at least one FCGR2C-ORF allele of the FcγRII/FcγRIII gene cluster; wherein said detecting comprises comparing FCGR2-ORF allele copy number in a sample from said subject to a copy number obtained by analysis of a recombinant nucleic acid construct comprising a first segment comprising the FCGR2C gene, or a fragment thereof, and a second segment comprising a CYBB reference gene or a fragment thereof, and correlating the presence of at least one FCGR2C-ORF allele in the FcγRII/FcγRIII gene cluster with a predisposition for developing an autoimmune disease, wherein said autoimmune disease is selected from the group consisting of Kawasaki disease, Systemic Lupus Erythematosus, Idiopathic Thrompocytopenic Purpura and rheumatoid arthritis.