Patent ID: 8188065

Claim:
A method of promoting bone growth in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I: wherein each R 1 , R 2 , R 4 , R 5 , R 6 , and R 7 is independently selected from the group consisting of H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, —OR 8 , —C 0-6 alkyl-NR 8 R 9 , —SR 8 , —C(O)R 8 , —C 0-6 alkyl-C(O)OR 8 , —C(O)NR 8 R 9 , —N(R 8 )C(O)R 9 , —N(R 8 )C(O)OR 9 , —N(R 8 )C(O)NR 8 R 9 , —OP(O)(OR 8 ) 2 , —S(O) 2 OR 8 , —S(O) 2 NR 8 R 9 , —CN, C 0-6 alkyl-cycloalkyl, heterocycloalkyl, C 0-6 alkyl-aryl and heteroaryl, wherein R 2 or R 4 combines with R 3 to form a bond; alternatively, R 4 and R 6 combine to form ═O; R 8 and R 9 are each independently a member selected from the group consisting of H and C 1-6 alkyl; and salts, hydrates, prodrugs, and isomers thereof, thereby promoting bone growth in the subject.