Patent ID: 7713983

Claim:
A compound of formula IA-ii: wherein R 1 and R 2 are each independently selected from optionally substituted methyl, ethyl, cyclopropyl, n-propyl, propenyl, cyclobutyl, CH(CH 3 )CH 2 CH 3 , or n-butyl; x is 0-1; y is 0; R 3 , when present, is selected from halogen, CN, NO 2 , —N(R′) 2 , —CH 2 N(R′) 2 , —OR′, —CH 2 OR′, —SR′, —CH 2 SR′, —COOR′, —NRCOR′, —CON(R′) 2 , —OCON(R′) 2 , COR′, —NHCOOR′, —SO 2 R′, —SO 2 N(R′) 2 , or an optionally substituted group selected from C 1 -C 6 aliphatic, aryl, heteroaryl, cycloaliphatic, heterocycloaliphatic, arylC 1 -C 6 alkyl, heteroarylC 1 -C 6 alkyl, cycloaliphaticC 1 -C 6 alkyl, or heterocycloaliphaticC 1 -C 6 alkyl; R 5a is an optionally substituted C 1 -C 6 aliphatic group, halogen, —OR′, —SR′, —N(R′) 2 , —NR′COR′, —NR′CON(R′) 2 , —NR′CO 2 R′, —COR′, —CO 2 R′, —OCOR′, —CON(R′) 2 , —OCON(R′) 2 , —SOR′, —SO 2 R′, —SO 2 N(R′) 2 , —NR′SO 2 R′, —NR′SO 2 N(R′) 2 , —COCOR′, —COCH 2 COR′, —OP(O)(OR′) 2 , —P(O)(OR′) 2 , —OP(O) 2 OR′, —P(O) 2 OR′, —PO(R′) 2 , or —OPO(R′) 2 ; and each occurrence of R is independently hydrogen or an optionally substituted C 1-6 aliphatic group; and each occurrence of R′ is independently hydrogen or an optionally substituted C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or R and R′, two occurrences of R, or two occurrences of R′, are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; provided that: when x is 0, and R 5a is Cl, Me, NO 2 , or OH, then R 1 and R 2 are not simultaneously Et or Me and provided that the following additional compounds are excluded: 2-(o-hydroxyphenyl)-4-dimethylamino-7-chloroquinazoline; and 2-(o-hydroxyphenyl)-4-dimethylamino-7-nitroquinazoline.