Patent ID: 8609713

Claim:
A compound of the formula (I): or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: A is a 5- or 6-membered heteroaryl ring or a 6-membered aryl ring; R 1 is —SO 2 R 10 ; R 2 is hydrogen, or alkyl; R 3 is aryl, heteroaryl, bicyclic heteroaryl, or —C(O)R 12 ; R 4 is —R 14 —R 15 ; R 5 is hydrogen, halo, aryl, heteroaryl, bicyclic heteroaryl, —R 23 —R 24 , or —R 23 —C(O)—R 24 ; R 10 is alkyl, —N═CHN(CH 3 ) 2 , or —NR 11a R 11b ; R 11a and R 11b are independently hydrogen or alkyl; or R 11a and R 11b taken together with the nitrogen atom to which each is attached form a 4-, 5-, or 6-membered heterocycle; R 12 is hydrogen, alkyl, aryl, heterocycle, heteroarylalkyl, —OR 13 or —NR 16 R 17 , R 13 is hydrogen, alkyl or arylalkyl; R 14 is aryl; R 15 is aryl, heteroaryl, heterocycle or —R 21 —R 22 ; R 16 and R 17 are independently hydrogen, alkyl, alkoxy, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclealkyl, hydroxyalkyl or R 18 R 19 N-alkyl-; R 18 and R 19 are independently hydrogen or alkyl; R 21 is aryl or heteroaryl; R 22 is arylalkyl; R 23 is aryl; and R 24 is heteroaryl or heterocycle.