Patent ID: 8575209

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein, independently for each occurrence: R 1 and R 2 are —Z A R 4 , wherein each Z A is independently a bond or an optionally substituted branched or straight C 1-6 aliphatic chain wherein up to two carbon units of Z A are optionally and independently replaced by —CO—, —CS—, —CONR A —, —CONR A NR A —, —OC 2 —, —OCO—, —NR A CO 2 —, —O—, —NR A CONR A —, —OCONR A —, —NR A NR A —, —NR A CO—, —S—, —SO—, —SO 2 —, —NR A —, —SO 2 NR A —, —NR A SO 2 —, or —NR A SO 2 NR A —; or any two adjacent R 2 groups together with the atoms to which they are attached form an optionally substituted carbocycle or optionally substituted heterocycle; R 4 is independently R A , halo, —OH, —NH 2 , —NO 2 , —CN, or —OCF 3 ; R A is independently hydrogen, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl; ring A is an optionally substituted 3-7 membered monocyclic ring having 0-3 heteroatoms selected from N, O, and S; n is and integer from 1 to 3 inclusive; ring B is wherein: p is 2, or 3; and R 3 is C 1 -C 6 aliphatic or halo; R′ 3 is —Z C R 6 ,where Z C is an optionally substituted branched or straight C 1-6 aliphatic chain wherein up to two carbon units of Z C are optionally and independently replaced by —CO—, —CS—, CONR C —, —CONR C NR C —, —CO 2 —, —OCO—, —NR C CO 2 —, —O—, —NR C CONR C —, —OCONR c —,—NR C NR C —,NR C CO—, —S—, —SO—, —SO 2 —, —NR C —, —SO 2 NR C —, —NR C SO 2 —, or —NR C SO 2 NR C —; R 6 is R C , halo, —OH, —NH 2 , —NO 2 , —CN, or —OCF 3 ; R C is hydrogen, an optionally substituted aliphatic, an optionally substited cycloaliphatic, an optionally substituted heterocycloaliphatic, or an optionally substituted heteroaryl; and wherein when one of the 2 or 3 R 3 is adjacent to R′ 3 and the adjacent R 3 is C 1 -C 6 aliphatic, then R′ 3 and the adjacent R 3 , together with the atoms to which they are attached, form an optionally substituted heterocycle.