Patent ID: 8039019

Claim:
A method for treating patients with hypertension, noninsulin-dependent diabetes mellitus or combinations of the forgoing comprising orally administering once-a-day to the patient a solid pharmaceutical dosage form comprising: (a) an antihyperglycemic drug which is metformin or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable controlled release excipient; and (b) an angiotensin antagonist selected from the group consisting of valsartan, losartan, candesartan, eprosartan, irbesartan, olmesartan, tasosartan, and telmisartan, and pharmaceutically acceptable salts, isomers or derivatives thereof; and wherein said dosage form exhibits the following dissolution profile when tested in a USP type 2 apparatus at 75 rpm in 900 mL of simulated intestinal fluid (pH 7.5 phosphate buffer) and at 37° C.: after 0.5 hours not less than 75% of the angiotensin antagonist is released; after 2 hours 0-25% of the antihyperglycemic drug is released; after 4 hours 10-45% of the antihyperglycemic drug is released; after 8 hours 30-90% of the antihyperglycemic drug is released; after 12 hours not less than 50% of the antihyperglycemic drug is released; after 16 hours not less than 60% of the antihyperglycemic drug is released; and after 20 hours not less than 70% of the antihyperglycemic drug is released.