Patent ID: 7226902

Claim:
An isolated complex comprising a TGF-beta binding protein and a BMP antagonist protein in specific association, wherein: (i) the TGF-beta binding protein comprises a sclerostin polypeptide that is capable of specifically binding a first TGF-beta superfamily member polypeptide that is selected from the group consisting of a BMP-5 polypeptide and a BMP-6 polypeptide, and (ii) the BMP antagonist protein is selected from the group consisting of a Chordin polypeptide and a Noggin polypeptide, said BMP antagonist protein being capable of specifically binding at least one second TGF-beta superfamily member polypeptide that is selected from the group consisting of a BMP-2 polypeptide, a BMP-4 polypeptide and a BMP-7 polypeptide, and wherein the complex is incapable of binding to the first TGF-beta superfamily member polypeptide.