Patent ID: 7951559

Claim:
A process to obtain a peptide of interest from a fusion peptide comprising: a) providing a population of fusion peptides comprising the general structure: IBT-CS-POI or POI-CS-IBT wherein; i) IBT is an inclusion body tag comprising an effective number of cysteine residues; ii) CS is a cleavage site; and iii) POI is a peptide of interest that does not include a cysteine residue; b) cleaving the population of fusion peptides at said cleavage site whereby the inclusion body tag is no longer linked to the peptide of interest and whereby a mixture of peptide molecules is produced comprising a plurality of inclusion body tags and a plurality of peptides of interest; c) subjecting the mixture of peptide molecules of step (b) to oxidizing conditions whereby the inclusion body tags are cross-linked; and d) recovering the peptide of interest.