Patent ID: 7645774

Claim:
A compound of the formula I: or a pharmaceutically acceptable salt said compound, wherein: L 1 is —C(O)—, —C(O)O—, —S(O 2 )—, —S(O)—, or —S—; L 2 is —S(O 2 )—; L 3 is —C(O)— or —S(O 2 )—; R 1 is selected from the group consisting of alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, —Si(alkyl) n (aryl) 3-n , aryl and heteroaryl, wherein each of said aryl or heteroaryl can be unsubstituted or optionally independently substituted with one to five moieties which can be the same or different and are independently selected from the group consisting of halogen, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxy, alkoxy, —N(R 7 ) 2 , —C(O)OR 7 , —C(O)N(R 7 ) 2 , —NC(O)R 7 , —NC(O)OR 7 , —NC(O)N(R 7 ) 2 , —NO 2 , —CN, —S(O 2 )R 7 , —S(O 2 )N(R 7 ) 2 , —NC(═N—CN)NHR 7 , and OH, with the proviso that: when R 1 is —NHR 7 or —N(R 7 ) 2 , L 1 —C(O)—, —S(O 2 )— or —SO—; R 2 is H, —OH, halogen, —N(R 7 ) 2 —, —CF 3 , alkoxy, alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl; R 3 and R 4 are the same or different, and are independently H or alkyl, or R 3 and R 4 taken together form a carbonyl group, i.e. C(═O); R 5 is H or alkyl; R 6 is selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, NHR 7 , N(R 7 ) 2 , aryl and heteroaryl, wherein each of said aryl and heteroaryl can be unsubstituted or optionally independently substituted with one to five moieties which moieties can be the same or different and are independently selected from the group consisting of halogen, alkyl, cycloalkyl, haloalkyl, haloalkoxy, alkoxy and OH; R 7 is selected from H, alkyl, haloalkyl, cycloalkyl, heterocyclylalkyl, aryl and heteroaryl, wherein each of said aryl and heteroaryl can be unsubstituted or optionally independently substituted with one to five moieties which moieties can be the same or different and are independently selected from the group consisting of halogen, alkyl, cycloalkyl, haloalkyl, haloalkoxy, alkoxy and/or OH; A is phenyl; X is independently selected from the group consisting of H, halogen, alkyl, cycloalkyl, haloalkyl, hydroxy, alkoxy, alkoxycarbonyl, haloalkoxy, —N(R 7 ) 2 , —N(R 7 )(C(O)R 7 ), —N(R 7 )(C(O)OR 7 ), —NO 2 and —CN, and when A is selected from the group consisting of pyridyl, thienyl, thiazolyl, quinolyl, isoquinolyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrimidyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, and benzothienyl, X can be oxide; and n is 0-3, with the proviso that (i) the two R 7 moieties in —N(R 7 ) 2 can be the same or different and are independently selected, and (ii) the moiety —N(R 5 )-L 3 —R 6 can optionally form a ring system.