Patent ID: 8108149

Claim:
A method of treating an insulin-like growth factor-1 deficiency (IGFD) disorder in an individual, the method comprising: a) calculating an insulin-like growth factor-1 (IGF-1) clearance rate using an IGF-1 binding protein-3 (IGFBP3) concentration measured in a blood, plasma, or serum sample from the individual; b) determining an IGF-1 production rate, wherein the IGF-1 production rate is calculated using a computer program that, when read by a computer, executes calculation of an IGF-1 production rate, wherein the IGF-1 production rate is calculated using the algorithm: IGF-1 production rate =(IGF-1 blood conc. )(clearance rate of IGF-1), wherein said IGF-1 blood conc is an IGF-1 concentration measured in a blood, plasma, or serum sample from the individual; and c) administering to the individual, based on the determined IGF-1 production rate, an effective amount of IGF 1 or growth hormone (GH), or an effective amount of a combination of GH and IGF-1, said administering being effective to treat IGFD in the individual.