Patent ID: 7615227

Claim:
A method of inducing neovascularization in a tissue, comprising introducing a CpG oligodeoxynucleotide into an area of the tissue wherein the formation of new blood vessels is desired, wherein the CpG oligodeoxynucleotide has a sequence as set forth as: 5′-N 1 DCGYN 2 -3′ (SEQ ID NO: 2) wherein at least one nucleotide separates consecutive CpGs; D is adenine, guanine, or thymidine; Y is cytosine or thymine, N is any nucleotide and N 1 +N 2 is from 0-26 bases; or 5′-N 1 RDCGYTN 2 -3′ (SEQ ID NO: 4) wherein at least one nucleotide separates consecutive CpGs; RD is selected from the group consisting of GpT, GpG, GpA, ApT and ApA; YT is selected from the group consisting of TpT or CpT; N is any nucleotide and N 1 +N 2 is from 0-26 bases; and wherein the CpG oligodeoxynucleotide is 8 to 30 nucleotides in length, thereby inducing neovascularization in the area of the tissue, wherein the tissue is a skin graft.