Patent ID: 8865174

Claim:
A method of treating a human subject suffering from an autoimmune disorder, comprising administering to the human subject an effective amount of a human antibody, or antigen-binding portion thereof, which binds to the p40 subunit of human interleukin-12 (IL-12) and dissociates from human IL-12 with a k off rate constant of about 1×10 −4 s −1 to 1×10 −5 s −1 , as determined by surface plasmon resonance, wherein the antibody is capable of binding to a first heterodimer and is also capable of binding to a second heterodimer, wherein the first heterodimer comprises the p40 subunit of human IL-12 and the p35 subunit of human IL-12, and wherein the second heterodimer comprises the p40 subunit of human IL-12 and a p19 subunit, thereby treating said subject.