Patent ID: 7012065

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof: wherein: A is X is selected from the group consisting of: —(CH 2 ) n — and —CH 2 —CH═CH—(CH 2 ) m —, where n is an integer of from 2 to 8 and m is an integer of from 2 to 5; Y is selected form the group consisting of: deuterium; halogen; SCN; NCO; NCS; OR 1 , where R 1 is selected from the group consisting of: hydrogen, C 1 –C 6 alkyl optionally substituted with aryl, substituted aryl, heteroaryl, substituted heteroaryl, halogen, C 3 –C 6 alkenyl optionally substituted with aryl, substituted aryl, heteroaryl, substituted heteroaryl, halogen, C 3 –C 6 alkynyl optionally substituted with aryl, substituted aryl, heteroaryl, substituted heteroaryl, halogen, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; OC(O)—W—R 1 , wherein W is absent, —O—, or —NH—, and R 1 is as previously defined; OCH 2 SR 2 , wherein R 2 is C 1 –C 6 alkyl optionally substituted with aryl, substituted aryl, heteroaryl, substituted heteroaryl; NHR 1 , wherein R 1 is as previously defined; N(R 10 )R 1 , wherein R 1 is as previously defined and R 10 is selected from the group consisting of: hydrogen, —CH 3 , and —CH 2 CH 3 ; SR 3 , wherein R 3 is selected from the group consisting of: hydrogen, thiol protecting group, and R 1 as previously defined; and S(O) n R 1 , where n in an integer 1 or 2 and R 1 is as previously defined; R is selected from the group consisting of: hydrogen and a hydroxyl protecting group; B is selected from the group consisting of: -αAbu-, -Val-, -Thr- and -Nva-; and U is selected from the group consisting of: -D)Ala-, -(D)Ser-, —[O-(2hydroxyethyl)(D)Ser]-, —[O-acyl(D)Ser]- and —[O-(2-acyloxyethyl)(D)Ser]-.