Patent ID: 7015229

Claim:
A compound of Formula I, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein: X is NR 3 R 4 ; Z is —O; Ar is selected from aryl and substituted aryl, R 1 is selected from halogen, —NO 2 , —CN, —R a , —OR a , —S(O) m R a , —NR a R a , —C(O)NR a R a , —C(S)NR a R a —S(O) m NR a R a , —NR a S(O) m R a , —NR a C(O)OR a , —NR a C(S)OR a , —OC(O)NR a R a , —OC(S)NR a R a , —NR a C(O)NR a R a , —NR a C(S)NR a R a , —C(O)OR a , —C(S)OR a , or —OC(O)OR a ; R 2 is selected from —R a , —S(O) m R a , —C(O)NR a R a , —C(S)NR a R a —S(O) m NR a R a , —C(O)OR a , —C(S)OR a , or —OC(O)OR a ; R 3 and R 4 are independently selected from R a , heterocycloalkyl, substituted heterocycloalkyl, substituted heteroaryl, substituted aryl, aryl cycloalkyl, substituted aryl cycloalkyl, heteroaryl cycloalkyl, substituted heteroaryl cycloalkyl, aryl heterocycloalkyl, substituted aryl heterocycloalkyl, heteroaryl heterocycloalkyl, or substituted heteroaryl heterocycloalkyl provided that at least one of R 3 or R 4 are heteroaryl, substituted heteroaryl, aryl cycloalkyl, substituted aryl cycloalkyl, heteroaryl cycloalkyl, substituted heteroaryl cycloalkyl, aryl heterocycloalkyl, substituted aryl heterocycloalkyl, heteroaryl heterocycloalkyl, substituted heteroaryl heterocycloalkyl, heterocycloalkyl or substituted heterocycloalkyl; R a each is selected from H, alkyl, cycloalkyl, haloalkyl, aryl, heteroaryl, or heterocycloalkyl optionally substituted with 1 to 5 of R t , —OR t , —S(O) m R t , NR t R t , oxo (═O), thione (═S), phenyl, heteroaryl, or heterocycloalkyl where phenyl, heteroaryl, and heterocycloalkyl are optionally substituted with 1 to 5 independently taken from R t ; and R t each is selected from H, halogen, —NO 2 , —NH 2 , —OH, —SH, —CN, —C(O)NH 2 , —C(O)—NHalkyl, —C(O)Nalkylalkyl, —Oalkyl, NHalkyl, Nalkylalkyl, —S(O) m alkyl, SO 2 NH 2 , SO 2 NHalkyl and SO 2 Nalkylalkyl, alkyl, cycloalkyl, haloalkyl, phenyl, benzyl, heteroaryl, or heterocycloalkyl where phenyl, benzyl heteroaryl and heterocycloalkyl may be optionally substituted with alkyl or halogen.