Patent ID: 8249813

Claim:
A computer-assisted method for determining at least one manner of introducing and moving at least one introduced entity from an at least one introduction site to at least one target tissue region in an organism, the method comprising: receiving data representing a property of i) the at least one introduced entity, ii) the at least one introduction site, iii) the at least one target tissue region, iv) at least one pathway to the target tissue region, and/or iv) a device used to introduce the at least one entity; calculating, from the received data, at least one modeling value at i) the at least one introduction site, ii) at least one pathway to the target tissue region, and iii) the at least one target tissue region; calculating at least one diffusion value representing a concentration gradient of the at least one introduced entity as it moves through the introduction site, the pathway, and the target tissue region; calculating at least one normal flow characteristic of at least one entity normally present in the organism; determining, using a processor, a plan for intraparenchymally introducing and moving the at least one introduced entity based on the at least one modeling value, the at least one diffusion value, and the at least one normal flow characteristic; calculating at least one biologically active transport value representing how the at least one introduced entity is transported through the introduction site, the pathway, and the target tissue region; and outputting from the computer data showing how the at least one entity is transported through the at least one introduction site, the pathway, and the target tissue region.