Patent ID: 8338370

Claim:
A method of promoting kidney development in a warm blood animal in need thereof, comprising: administering to the warm blooded animal a pharmaceutical composition comprising 0.1-1 g/kg body weight concentration of at least one kidney-development promoting component comprising: i) colony stimulating factor-1 protein (CSF-1); ii) a precursor of CSF-1; iii) a variant of CSF-1, comprising an isoform of CSF-1; iv) an analogue of CSF-1 having retained substantial similarity in biological function to CSF-1; or v) a derivative of CSF-1 having retained substantial similarity in biological function to CSF-1; wherein: a) the precursor, variant, analogue, or derivative of CSF-1 comprise the C-terminal fragment of CSF-1, comprising the C-terminal 150 amino acids of the 536 amino acid CSF-1 protein; and b) the promoted kidney development comprises one or more of the following: an increase in kidney weight, an increase in kidney growth, kidney maturation, increased nephrogenesis, or enhanced nephrogenesis.