Patent ID: 7141655

Claim:
A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof: wherein: (i) each R 1 or R 2 , independently, is O − , S − , OR 3 or SR 3 with the provision that if either R 1 or R 2 is absent, the other remaining group is ═O or ═S; or R 1 and R 2 , together with the arsenic atom, form a ring according to one of the general structural Formulae (II), (III), (IV), or (V): wherein R 3 is H, CH(OH)CH 2 OH or (CH 2 ) q —Y, wherein q is 1–4, and Y is H, OH, NH 2 , SH, COOH, OAc, CONH 2 or CN; and Z represents a hydrocarbon chain comprising 2–4 singly or doubly bonded carbon atoms wherein each carbon atom may be further substituted with one or more groups selected from hydrogen, methyl, ethyl, 1-propyl, 2-propyl, methoxy, hydroxy, amino, carboxy, sulfo, oxo, thiol, halo (fluoro, chloro, bromo, or fluoro), (CH 2 ) n″ SO 3 —, and (CH 2 ) n″ SO 3 H, wherein n″ is 1 or 2; (ii) R 4 , R 5 , R 6 and R 7 are each independently H, F, OR 3 , R 3 , OAc, NH 2 , N(C 1 –C 4 alkyl) 2 ; or R 4 with R 5 , or R 6 together with R 7 , or both, form a ring; (iii) R 8 is a linear or branched optionally substituted spacer having a minimum length of approximately 1.5 and a maximum length of approximately 15 Ångstroms; and (iv) X is a detectable group, wherein X is a fluorochrome.