Patent ID: 8624039

Claim:
An automated method for preparing (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[ 18 F]-fluoropropyl)-2,3-dimethoxybenzamide ([ 18 F]fallypride), comprising: absorbing a fluorine-18 to a polymer ion exchange cartridge; extracting fluorine-18 by inputting 5.0-25 μL of 40% TBAHCO 3 or 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (K2.2.2)/K 2 CO 3 (5-25 mg/0.5-3.0 mg) as a phase-transfer catalyst in a mixture of alcohol/water (1.0/0.2 (v/v)) or alcohol as an elution solvent into the polymer ion exchange cartridge trapped by the fluorine-18; preparing a (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[ 18 F]-fluoropropyl)-2,3-dimethoxybenzamide ([ 18 F]fallypride) product by removing the solvent from the extracted fluorine-18, by inputting tosylate precursor in CH 3 CN as a reaction solvent into a reactor and by reacting the same 5-35 minutes at 50-120° C.; and purifying a pure (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[ 18 F]-fluoropropyl)-2,3-dimethoxybenzamide ([ 18 F]fallypride) by separating the prepared (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[ 18 F]-fluoropropyl)-2,3-dimethoxybenzamide ([ 18 F]fallypride) product.