Patent ID: 7235232

Claim:
A purified hybrid interferon-α polypeptide, comprising a first amino acid sequence consisting of residues 1-75 of interferon-α21b, a second amino acid sequence consisting of residues 76-81 of interferon-α2c or residues 76-81 of interferon-α21b; a third amino acid sequence consisting of the sequence LDKFXTELXQQLND (SEQ ID NO: 43) or the sequence LEKFXTELXQQLND (SEQ ID NO: 44), wherein X is any amino acid residue; and a fourth amino acid sequence consisting of residues 96-166 of interferon-α2c; wherein the C-terminal residue of the first amino acid sequence is fused to the N-terminal residue of the second amino acid sequence; and the C-terminal residue of the second amino acid sequence is fused to the N-terminal residue of the third amino acid sequence; and the C-terminal residue of the third amino acid sequence is fused to the N-terminal residue of the fourth amino acid sequence; and wherein the hybrid interferon-α polypeptide has interferon-α protein biological activity.