Patent ID: 7375130

Claim:
A compound of formula (I) wherein X is S; R1 is -Alk-COOH, -Alk-C(═O)—(O) m -Ar, -Alk-C(═O)—(O) m -Het, -Alk-C(═O)—(O) m -Alk, -Alk-C(═O)—(O) m -cycloalkyl, -Alk-C(═O)NRR′, -Alk-(O) m -Ar, -Alk-O-Alk, -Alk-O-Alk-Ar, -Alk-O-Het; R2 is —OH, —OAlk, —NR7R8, —OAr, —OHet or —O-cycloalkyl; R7 is H or -Alk; R8 is —H; -Alk′ or -cycloalkyl, which Alk′ or cycloalkyl is optionally substituted by one or more of —OAlk, —CN, —OHet, —OH, —C(═O)—(O) m Alk, —C(═O)—(O) m Ar, —C(═O)—(O) m Het, —C(═O)—(O) m -cycloalkyl, —COOH or —NO 2 ; —Ar′ or Het′, which Ar′ or Het′ is optionally substituted by one or more of Hal, —OAlk, —OH, -Alk, —Ar, —OAlkAr, —OH, —CN, —OAr, —CF 3 , -AlkAr, —COOH—NRR′, -Het, —C(═O)—(O) m Alk, —C(═O)—(O) m Ar, —C(═O)—(O) m Het, —C(═O)—(O) m -cycloalkyl or NO 2 ; or R7 and R8 form, together with the nitrogen atom to which they are attached, a nitrogenous heterocycle of 5 to 10 atoms; R3, R4, R5 and R6, which may be identical or different, are each independently, H, -Hal, —OH, -Alk, —OAlk, —CN, —CF 3 , —NRR′ or —NO 2 ; Alk, which may be identical or different, is optionally and independently substituted by one or more of -Hal, —OAlk, —Ar, —OAlkAr, —OH, —CN, —OAr, —CF 3 , —COOH, —NRR′, —C(═O)—(O) m Alk, -Het or —NO 2 ; Ar, each of which may be identical or different, is optionally and independently substituted by one or more of -Hal, —OAlk, -Alk, —Ar, —OAlkAr, —OH, —CN, —OAr, —CF 3 , -AlkAr, —COOH, —C(═O)—(O) m Alk, -Alk—C(═O)—(O) m Alk, —NRR′, -Het, —NO 2 , —S(O) n —Ar or —S(O) n Alk; R and R′ are, each independently H or Alk; is 0 or 1; is 0, 1 or 2; Alk and Alk′ are, each independently, an alkyl radical; Ar and Ar′ are, each independently, an aryl radical; Het and Het′ are, each independently, a heteroarsrl radical; and Hal is a halogen radical; or pharmaceutically acceptable salt thereof, with the exception of the compounds for which: 1) R1=CH 2 -phenyl, optionally substituted by —NO 2 or —OMe, R2=—OMe, —OEt or —OH, R3, and R6=H, R4, and R5=H or —OMe, and X═S; 2) R1=—CH 2 —C(═O)Me, R3, R4, R5, and R6=H, X═S, and R2=—OMe; 3) R1=—CH 2 —CO 2 Me, R3, R4, R5, and R6=H, R2=—OMe or —OH, and X═S; and R1=—CH 2 CO 2 H, R3, R4, R5, and R6=H, R2=OH, and X═S; and 4) R1=—CH 2 -phenyl, R2=—NH 2 , X═S, and R5=—OMe.