Patent ID: 8530640

Claim:
A bicyclic nucleoside analog having formula I: wherein: Bx is a heterocyclic base moiety; Z is O or S; one of T 1 and T 2 is H or a hydroxyl protecting group and the other of T 1 and T 2 is H, a hydroxyl protecting group or a reactive phosphorus group; q 1 and q 2 are each, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl or substituted C 2 -C 6 alkynyl; Q consists of from 1 to 4 linked biradical groups independently selected from —O—, —S—, —N(R 1 )—, —C(R 1 )(R 2 )—, —C(R 1 )═C(R 2 )—, —C(R 1 )═N—, —C(═NR 1 )—, Si(R 1 )(R 2 )—, —SO 2 —, —SO—, —C(═O)— and —C(═S)—; each R 1 and R 2 is, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl, substituted C 2 -C 6 alkynyl, halogen, OJ 1 , NJ 1 J 2 , SJ 1 , N 3 or CN, wherein each J 1 and J 2 is, independently, H, C 1 -C 6 alkyl, Substituted C 1 -C 6 alkyl or a protecting group; and wherein each substituted group is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, oxo, OE 1 , NE 1 E 2 , SE 1 , N 3 , OC(═O)E 1 and CN, wherein each E 1 and E 2 is, independently, H, C 1 -C 6 alkyl or a protecting group.