Patent ID: 8629150

Claim:
A compound of formula I where Ar 1 is phenyl or pyridinyl substituted with 1 R 2 ; R 1 is alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, halocycloalkyl, cycloalkenyl, benzyl, indanyl, or alkylcarbonyl; R 2 is hydrogen, cyano, halo, alkyl, haloalkyl, alkoxy, or haloalkoxy; R 3 is hydrogen, alkyl, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, ((alkylcarbonyl)amino)alkyl, ((haloalkylcarbonyl)amino)alkyl, ((alkoxycarbonyl)amino)alkyl, ((benzyloxycarbonyl)amino)alkyl, alkylcarbonyl, alkoxycarbonyl, benzyloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkyaminocarbonyl; R 4 is hydrogen, alkyl, (amino)alkyl, (alkylamino)alkyl, or (dialkylamino)alkyl; R 5 is hydrogen, alkyl, (amino)alkyl, (alkylamino)alkyl, or (dialkylamino)alkyl; Q is an alkylene or alkenylene chain containing 0-6 groups selected from the group consisting of O, NR 3 , S, S(O), S(O 2 ), C(O)O, C(O)NR 4 , OC(O)NR 4 , NR 4 C(O)NR 4 , and Z, provided that any O or S atom does not directly bond to another O or S atom, such that ring A is 13-36 membered; and where the alkylene or alkenylene chain is substituted with 0-6 substituents selected from the group consisting of alkyl, alkylene, hydroxy, and alkoxy; X is O, CH 2 , CO, CO 2 , or C(O)NR 5 ; and Z is C 3-7 cycloalkylene or phenylene; or a pharmaceutically acceptable salt thereof.