Patent ID: 8557980

Claim:
A method of forming a protected boronic acid, comprising: reacting in a reaction mixture an imino-di-carboxylic acid, and an organoboronate salt represented by formula (I): [R 1 —B(OR 2 )(OR 3 )(OR 4 )] − M + (I); wherein R 1 is an organic group, R 2 , R 3 and R 4 independently are selected from the group consisting of an alkyl group and an aryl group, and M + is selected from the group consisting of a metal ion, a metal halide ion and an ammonium ion; and the reaction mixture further comprises a polar aprotic solvent; wherein the reacting comprises maintaining the reaction mixture at a temperature of at least 100° C.; and thereby forming a protected organoboronic acid represented by formula (III) in the reaction mixture: wherein R 10 , R 11 , R 12 , R 13 and R 14 independently are selected from the group consisting of a hydrogen group and an organic group.