Patent ID: 8604048

Claim:
A pharmaceutical composition, comprising: at least one pharmaceutically acceptable vehicle; and at least one tetracyclic compound of formula (I), or a pharmaceutically acceptable salt of the tetracyclic compound: wherein: R 1 represents a hydrogen atom, an alkyl radical having 1 to 4 carbon atoms, an aminoalkyl group having 1 to 4 carbon atoms, or a monoalkylaminoalkyl, or dialkylaminoalkyl group wherein the two alkyl radicals have 1 to 4 carbon atoms; R 2 represents a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms; R 3 represents an alkyl radical having 1 to 4 carbon atoms; —OR 4 represents a hydroxyl radical, an alkoxy radical having 1 to 4 carbon atoms or an alkoxy radical of formula —O—(CH 2 ) n —Z, or an ester radical having 1 to 4 carbon atoms, or an ester radical of formula —OC(O)Z, wherein Z is a cycloalkyl group having 3 to 6 carbon atoms, or an aryl group, chosen from phenyl, benzyl, pyridyl, pyrimidyl, triazyl, and oxazolyl groups, wherein the aryl group is optionally substituted at the ortho, meta, or para position by one, two, or three substituents, which are identical or different, selected from the group consisting of a halogen atom, —OH, —NO 2 , —NH 2 , a alkyl radical having 1 to 4 carbon atoms, an alkoxy radical having 1 to 4 carbon atoms, monoalkylamino radical having 1 to 4 carbon atoms, and dialkylamino radical having 1 to 4 carbon atoms, and n is an integer ranging from 1 to 4; or —OR 4 represents a radical of formula: wherein: V is selected from the group consisting of CH 2 , O, NH, and N-alkyl, wherein the alkyl group has 1 to 4 carbon atoms, and n′ is equal to 2 or 3; R 5 represents a hydrogen atom or a dialkylamino-methyl group in which the alkyl radical has 1 to 4 carbon atoms; R 6 represents an oxygen atom bound to the ring D by a double bond or a halogen atom; R 7 represents a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms; R 8 represents a hydrogen atom, an alkyl radical, a hydroxyalkyl radical, an alkylcarboxyalkylene radical of formula or a dialkylphosphatealkylene radical of formula, wherein the alkyl and alkylene radicals have 1 to 4 carbon atoms, or an ester radical having 1 to 4 carbon atoms, with the proviso that R 8 is present only when R 6 is an oxygen atom bound to the D ring by a double bond.