Patent ID: 7560586

Claim:
A compound of Formula I: wherein: Z is CH or CR 3 ; wherein k is 0-4; p is 0-8; n is 2-8; q is 0 or 1; Q is C 3 -C 8 cycloalkyl or phenyl; wherein said C 3 -C 8 cycloalkyl, or phenyl are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-CO 2 R 11 , —C 0 -C 6 alkyl-C(O)SR 11 , —C 0 -C 6 alkyl-CONR 12 R 13 , —C 0 -C 6 alkyl-COR 14 , —C 0 -C 6 alkyl-NR 12 R 13 , —C 0 -C 6 alkyl-SR 11 , —C 0 -C 6 alkyl-OR 11 , —C 0 -C 6 alkyl-SO 3 H, —C 0 -C 6 alkyl-SO 2 NR 12 R 13 , —C 0 -C 6 alkyl-SO 2 R 11 , —C 0 -C 6 alkyl-SOR 14 , —C 0 -C 6 alkyl-OCOR 14 , —C 0 -C 6 alkyl-OC(O)NR 12 R 13 , —C 0 -C 6 alkyl-OC(O)OR 14 , —C 0 -C 6 alkyl-NR 12 C(O)OR 14 , —C 0 -C 6 alkyl-NR 12 C(O)NR 12 R 13 , and —C 0 -C 6 alkyl-NR 12 COR 14 , where said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents; W 1 and W 2 are each independently C 3 -C 8 cycloalkyl or aryl; each R 1 and R 2 is independently selected from H, C 1 -C 6 alkyl, —OH, —O—C 1 -C 6 alkyl, —SH, and —S—C 1 -C 6 alkyl; each R 3 is the same or different and is independently selected from halo, cyano, nitro, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-CO 2 R 11 , —C 0 -C 6 alkyl-C(O)SR 11 , —C 0 -C 6 alkyl-CONR 12 R 13 , —C 0 -C 6 alkyl-COR 14 , —C 0 -C 6 alkyl-NR 12 R 13 , —C 0 -C 6 alkyl-SR 11 , —C 0 -C 6 alkyl-OR 11 , —C 0 -C 6 alkyl-SO 3 H, —C 0 -C 6 alkyl-SO 2 NR 12 R 13 , —C 0 -C 6 alkyl-SO 2 R 11 , —C 0 -C 6 alkyl-SOR 14 , —C 0 -C 6 alkyl-OCOR 14 , —C 0 -C 6 alkyl-OC(O)NR 12 R 13 , —C 0 -C 6 alkyl-OC(O)OR 14 , —C 0 -C 6 alkyl-NR 12 C(O)OR 14 , —C 0 -C 6 alkyl-NR 12 C(O)NR 12 R 13 , and —C 0 -C 6 alkyl-NR 12 COR 14 , wherein said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents; each R 4 and R 5 is independently H or C 1 -C 4 alkyl; R 6 and R 7 are each independently H or C 1 -C 4 alkyl; R 8 and R 9 are each independently H or C 1 -C 4 alkyl; R 10 is H, C 1 -C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, —C 0 -C 6 alkyl-Ar, or —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl; R 11 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, or —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl; each R 12 and each R 13 are independently selected from H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl; and R 14 is C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, or —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl; provided that R 10 is not H or methyl when p is 1 and R 1 and R 2 are each H, k is 0, n is 3 and each R 4 and R 5 are H, q is 1 and R 8 and R 9 are each H, Q is unsubstituted phenyl or 4-methoxyphenyl or 2-chloro-3-trifluoromethyl-phenyl, R 6 and R 7 are each H, W 1 is unsubstituted phenyl and W 2 is unsubstituted phenyl or unsubstituted cyclohexyl; or a pharmaceutically acceptable salt thereof.