Patent ID: 7060711

Claim:
A method for selectively binding a 5-HT2B receptor comprising administering to the mammal a pharmaceutically effective amount of a compound according to the formula or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, phenoxy, trifluoromethyl, trifluoromethoxy, amino, dimethylamino, —CON(CH 3 ) 2 and —CON(C 2 H 5 ) 2 ; R 2 is a methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, hydroxy or hydrogen, or R 1 and R 2 together form a five-membered heterocycle, wherein a heteroatom in said heterocycle is an oxygen atom; R 3 is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl isobutyl, pentyl, hexyl, hydroxy and hydrogen; R 4 is selected from the group consisting of hydroxy, methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, trifluoromethyl, amino, dimethylamino, diethylamino, fluorine, chlorine, bromine, methyl, ethyl, propyl, isopropyl, butyl and hydrogen; R 5 is methyl or hydrogen; R 6 is methyl or ethyl; and X is S, N or Se; provided that when R 1 is ethoxy and X is S, at least one of R 2 , R 3 , R 4 and R 5 is not hydrogen.