Patent ID: 7300921

Claim:
An isolated compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein, A is selected from —C(NH)NHR 1 , CH 3 , H and R 1 is selected from H, C 1-6 alkyl, C 6-10 aryl, C(O)C 1-6 alkyl and C(O)C 6-10 aryl; R 2 and R 3 are each independently selected from H, C 1-6 alkyl, C 2-7 alkene and C 6-10 aryl; R 4 is selected from H and CH 3 ; Z is OH or O when taken with adjacent carbon atom to form a carbonyl; or Z may be a tetrahydropyranoxy of formula: R 5 is selected from H, COOH, C 1-6 alkyl and C(O)OC 1-6 alkyl; R 6 , R 7 and R 8 are each independently selected from H, C 1-6 alkyl and C(O)C 1-6 alkyl; or R 6 , R 7 and R 8 may each independently be absent when the adjacent oxygen and carbon atoms are taken together to form a carbonyl; or R 6 , R 7 and R 8 may each independently be a bond when any of two neighboring R 6 , R 7 and R 8 are taken together with attached oxygen and carbon atoms to form a 1,3-dioxolane ring of formula: R 9 and R 10 are each independently selected from H, C 1-6 alkyl, C 2-7 alkene and C 6-10 aryl; or R 9 and R 10 are taken together with adjacent carbon atom to form a ring having from 5 to 7 carbons; D is selected from OH, NH 2 , NH(C 1-3 alkyl), N(C 1-3 alkyl) 2 , OC 1-3 alkyl and R 11 is selected from H and C 1-3 alkyl.