Patent ID: 8470772

Claim:
A compound of the formula: X-Glu-Val-Val-Ala-Leu-Y-Arg-Leu-Z (SEQ ID NO:14) wherein: (a) X is selected from the group consisting of (i) zero amino acids, (ii) a hydroxyamino acid, (iii) a saccharide-modified hydroxyamino acid, (iv) X 1 -X 2 , wherein X 1 is a hydroxyamino acid, a saccharide-modified hydroxyamino acid or Asn, and X 2 is a hydroxyamino acid, a saccharide-modified hydroxyamino acid or Asn; and (v) X 3 -X 4 -X 5 , wherein X 3 is a non-natural amino acid or an acetylated amino acid, X 4 is a hydroxyamino acid, a saccharide-modified hydroxyamino acid or Asn, and X 5 is a hydroxyamino acid, a saccharide-modified hydroxyamino acid or Asn, (b) Y is a hydroxyamino acid, a saccharide-modified hydroxyamino acid or Asn, and (c) Z is selected from the group consisting of (i) a non-natural amino acid which resists exopeptidase activity in a mammal, and (ii) Z 1 -Z 2 , wherein Z 1 is a single natural or non-natural amino acid and Z 2 is a single natural or non-natural amino acid which resists exopeptidase activity in a mammal, wherein the C-terminal carboxyl group is optionally derivatized as an ester or an amide, or a salt thereof.