Patent ID: 8067621

Claim:
A compound having the formula (IF): or a pharmaceutically acceptable salt thereof, wherein Q forms a heterocycloalkyl ring consisting of a tetrahydropyranyl or tetrahydrothiopyran ring unsubstituted or substituted with one or more independently selected L 3 groups; X is O; m is 1; R 4 is hydrogen; each L 3 is independently selected from the group consisting of: —CN, —R 5 , —OR 5 ; and —N(R 5 ) 2 ; Each R 5 is independently selected from the group consisting of: (1) H, —S(O) 2 —(C 1 -C 6 )haloalkyl, —S(O) 2 unsubstituted cycloalkyl, —(C 1 -C 6 )alkylene-NHS(O) 2 —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkylene —NHS(O) 2 unsubstituted cycloalkyl, —(C 1 -C 6 )alkylene-(S(O) 2 —(C 1 -C 6 )alkyl, dihydroxyl- substituted (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyleneC(O)—(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene —NHC(O) 2 —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene-unsubstituted and substituted heteroaryl, wherein the unsubstituted heteroaryl is benzothiazolyl, hydrothiazolyl, diazolyl, benzimidazolyl and the substituted heteroaryl is isoxazolyl substituted by hydroxyl, (C 1 -C 6 )alkyl, hydroxyl substituted (C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl) 2 , —(C 1 -C 6 )alkylene-C(O)—(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkylene-NHC(O)—(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene-NHC(O)—(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkylene-NHS(O) 2 —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene-NHS(O) 2 —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkylene-O—C(O)—NH—(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene-O—C(O)—NH-unsubstituted cycloalkyl, —(C 1 -C 6 )alkylene-CN, -unsubstituted cycloalkyl, —C(O)NH 2 , —C(O)—N(alkyl) 2 , —(C 1 -C 6 )alkylene-NH 2 , -hydroxyl substituted (C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkylene-NH—C(O)-unsubstituted cyclopropyl, —(C 1 -C 6 )alkylene-O—C(O)—(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylene-O—S(O) 2 —(C 1 -C 6 )alkyl, —CN, —(C 1 -C 6 )alkylene-NHS(O) 2 -unsubstituted heterocycloalkyl and —(C 1 -C 6 )alkylene-unsubstituted heterocycloalkyl; Ar is unsubstituted phenyl, or phenyl substituted with one or more L 1 groups; each L 1 is independently selected from the group consisting of halogen and —CF 3 ; and n is 0, 1, 2 or 3; and provided that for the substituent —OR 5 , the R 5 moiety and the oxygen atom to which it is bound to does not form a —O—O— group; and provided that for the substituents —OR 5 , and —NHR 5 , R 5 is not —CH 2 OH, —CH 2 NH 2 , —CH 2 NHalkyl, —CH 2 NHaryl or —C(O)OH.