Patent ID: 7674767

Claim:
An orally administrable composition containing particles with a particle size of 500 nm or less, comprising: 0.1 to 30 weight % of a complex of a charged water-soluble drug and a counter-ion substance in which the charged water-soluble drug is ionically bonded with the counter-ion substance, wherein said counter-ion substance is an anionic compound selected from the group consisting of sodium salt of C 8-18 fatty acid, sodium salt of bile acid, sodium alginate, and sodium carboxymethylcellulose, or a cationic compound selected from the group consisting of carnitine salt, benzalkonium chloride, cetrimide, and mixtures thereof; 0.5 to 80 weight % of a lipid, wherein said lipid is an aliphatic alcohol selected from the group consisting of monoglyceride, diglyceride, propyleneglycol fatty acid ester, glycerol fatty acid ester, cetostearyl alcohol, cetyl alcohol, and mixtures thereof; 0.5 to 80 weight % of a polymer, wherein said polymer is selected from the group consisting of methacrylic acid copolymer, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, cellulose acetate phthalate, shellac, chitosan, hydroxypropyl methylcellulose and its derivative, ethylcellulose, methylcellulose, polyvinylalcohol, sodium alginate, carbomer, and mixtures thereof; 0.1 to 30 weight % of a cryoprotective agent, wherein the cryoprotective agent is selected from the group consisting of glucose, mannitol, sorbitol, trehalose, amino acid, albumin, and mixtures thereof; and 1 to 80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05 to 3 and said complex is entrapped in said lipid and said polymer is inserted between said lipid.