Patent ID: 7582766

Claim:
A compound of formula (1) or its enantiomers or diastereoisomers thereof: wherein R 1 is H, (C 1-6 ) alkyl, halo, (C 1-6 )haloalkyl, (C 1-6 )alkoxy, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino, di((C 1-6 ) alkyl) amino, (C 3-7 )cycloalkyl, or phenyl; X 1 is CR 2 ; one or both free positions on the phenyl ring may be substituted with R 2 and each R 2 is independently: H, (C 1-6 )alkyl, halo, (C 1-6 )haloalkyl, (C 1-6 )alkoxy, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino or di((C 1-6 )allyl)amino; A is piperidinyl optionally substituted with one or more of (C 1-6 )alkyl, halo, (C 1-6 )haloalkyl, (C 1-6 )alkoxy, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino, or di((C 1-6 )alkyl)amino, aryl, O-aryl, S-aryl, NH-aryl or (C 1-6 )alkyl-aryl; R 4 is phenyl optionally substituted with one or more of (C 1-6 )alkyl, halo, (C 1-6 )haloalkyl, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino, di((C 1-6 )alkyl)amino, aryl, (C 1-6 )alkyl-aryl, or (C 1-6 )alkoxy, wherein said (C 1-6 )alkoxy is optionally substituted with aryl; Z is O or S; Y is CH 2 or NH; B is: wherein R 5 is (C 3-7 )cycloalkyl, halo, (C 1-6 )haloalkyl, (C 1-6 )alkoxy, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino, di((C 1-6 )alkyl)amino, hydroxyl or sulfhydryl; X 2 is CR 7 ; R 6 is halo, (C 1-6 )haloalkyl, (C 1-6 )alkoxy, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino, di((C 1-6 )alkyl)amino, hydroxyl or sulfhydryl; and R 7 is H, (C 1-6 )alkyl, halo, (C 1-6 )haloalkyl, (C 1-6 )alkoxy, (C 1-6 )alkylthio, amino, (C 1-6 )alkylamino, di((C 1-6 )alkyl)amino, hydroxyl or sulfhydryl; and R C is COOH, CONHR 9 , SO 2 NHR 9 , CONHSO 2 R 9 or CONHSO 2 NHR 9 , wherein R 9 is H, (C 1-6 )alkyl, (C 3-6 )cycloalkyl or phenyl; provided that when Y is NH, R 6 cannot be hydroxyl or sulfhydryl; or a pharmaceutically-acceptable salt or ester thereof.