Patent ID: 8729079

Claim:
A compound of Formula (I): wherein: R 1 is NR 4 R 5 , optionally substituted C 1 to C 6 alkoxy, optionally substituted C 6 to C 14 aryl, optionally substituted heteroaryl, optionally substituted 3-10 membered monocyclic or bicyclic cycloalkyl, or optionally substituted 3-10 membered monocyclic or bicyclic heterocyclyl, wherein: 3-4 membered cycloalkyl and heterocyclyl are saturated; (ii) hydrogen atoms on the same carbon atom of said cycloalkyl or heterocyclyl are optionally replaced with an optionally substituted 3-6 membered cycloalkyl or heterocyclyl to form a spirocycloalkyl or spiroheterocyclyl; and (iii) hydrogen atoms on the same atom of said cycloalkyl or heterocyclyl are optionally replaced with O to form an oxo substituent; R 2 is optionally substituted phenyl, —O—(C 1 to C 6 alkyl)-optionally substituted phenyl, or optionally substituted 5-6 membered heteroaryl, with the proviso that when R 2 is 4-pyridyl, the 4pyridyl lacks a carbonyl substituent at the 2 nd position; R 4 and R 5 are: (a) independently selected from the group consisting of H, C 1 to C 6 alkyl, C 1 to C 6 hydroxyalkyl, C 3 to C 8 cycloalkyl, and -(C 1 to C 6 alkyl)N(C 1 to C 6 alkyl)(C 1 to C 6 alkyl); (b) joined to form an optionally substituted 3-8 membered heterocyclyl, wherein; (bi) hydrogen atoms on the same carbon atom of said heterocyclyl are optionally replaced with an optionally substituted 3-6 membered cycloalkyl or heterocyclyl to form a spirocycloalkyl or spiroheterocyclyl; and (bii) hydrogen atoms on the same atom of said heterocyclyl (b), cycloalkyl (bi), or heterocyclyl (bi), are optionally replaced with O to form an oxo substituent; or a pharmaceutically acceptable salt or ester thereof.