Patent ID: 7856409

Claim:
A server on which screening of nucleotide sequences is executed through a network, said server comprising: a database for storing target nucleotide sequence data, wherein the target nucleotide sequence data is obtained from a target nucleotide sequence and wherein the database executes on a hardware processor; a sending and receiving unit for receiving target designation data and a probe nucleotide sequence that may be bound to the target nucleotide sequence through the network, as well as sending the result of the screening through said network, wherein the sending and receiving unit executes on a hardware processor; a complementary sequence data storing unit for generating complementary sequence data from said probe nucleotide sequence and storing the complementary sequence data, wherein the complementary sequence data storing unit executes on a hardware processor; an evaluation processing unit for searching through said database using said target designation data, evaluating the searched target nucleotide sequence data and said complementary sequence data in descending order from a first edit distance value to a second edit distance value, the second edit distance value being lower than the first edit distance value, further wherein an edit distance is the number of times nucleotides of the target nucleotide sequence are required to be adjusted to generate the complementary sequence data, and determining the binding possibility of said probe nucleotide sequence to said target nucleotide sequence, as well as transmitting the result to said sending and receiving unit, wherein the evaluation processing unit comprises a partial sequence designating unit for determining a partial sequence of the target nucleotide sequence to be evaluated, a termination-determining unit for dynamically determining a termination point for the evaluation of the partial sequence, and an evaluation execution unit for executing an evaluation of the partial sequence. and further wherein the evaluation processing unit executes on a hardware processor; and a maximum edit distance storing unit for storing a maximum acceptable edit distance between said target nucleotide sequence and said probe nucleotide sequence, wherein the maximum edit distance storing unit executes on a hardware processor, wherein the termination-determining unit compares a value of min_k and the maximum edit distance k, wherein min_k represents a minimum value of edit distance, and wherein the termination-determining unit commands the evaluation processing unit to stop evaluating at a point when the value of min_k becomes greater than k.