Patent ID: 7538132

Claim:
An aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivative of formula wherein R 1 is hydrogen, halogen, lower alkoxy, phenyloxy or benzyloxy; R 2 is lower alkyl, (CH 2 ) n —O-lower alkyl or phenyl; R 3 is hydrogen or lower alkyl; R 4 and R 5 are each independently hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkynyl, —(CHR) n -aryl, unsubstituted or substituted by halogen, lower alkyl or lower alkoxy, —(CH 2 ) n -non aromatic heterocyclic ring, unsubstituted or substituted by one or two lower alkyl groups, —(CH 2 ) n -aromatic heterocyclic rings, —(CR 2 ) n -cycloalkyl, unsubstituted or substituted by one to three substituents, selected from the group consisting of hydroxy or lower alkyl, —(CHR) n —O-lower alkyl, —(CR 2 ) n —OH, or —(CHR) n —NR′R″, or R 4 and R 5 together with the N-atom to which they are attached form the ring 8-aza-bicyclo[3.2.1]octane, substituted by hydroxy, or 3,4-dihydro-1H-isoquinoline, or a non aromatic heterocyclic ring, unsubstituted or substituted by one or two substituents, selected from the group consisting of C(O)O-lower alkyl, lower alkyl, lower alkyl substituted by halogen, cycloalkyl, hydroxy, halogen, N(R)C(O)-lower alkyl, —(CH 2 ) n —O-lower alkyl, or by an aromatic heterocyclic ring; R is hydrogen, hydroxy, or lower alkyl, wherein when there are two R groups, each R can be the same or different; R′ and R″ are each independently hydrogen or lower alkyl; n is 0, 1, 2, 3 or 4; and m is 1, 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.