Patent ID: 7652057

Claim:
A compound of the formula (I): wherein R 1 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, haloalkyl, aryl, pyridinylmethyl or heterocyclyl; and with the proviso that in case R 1 is hydrogen then R 3 is adamantanyl or adamantanyl substituted with one to three substituents independently selected from alkyl, hydroxy, halogen and haloalkyl; R 2 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, benzothiazolyl, bicyclo(2.2.1)heptyl or bicyclo(2.2.2)octyl, wherein bicyclo(2.2.1)heptyl and bicyclo(2.2.2)octyl are optionally substituted with one to three substituents independently selected from alkyl, hydroxy, halogen and haloalkyl; or R 1 and R 2 together with the nitrogen atoms to which they are attached form pyrazolidine, hexahydro-pyridazine, (1,2) diazepane or 2,3,4,5, tetrahydro-1H-benzo(c)(1,2)diazepine, wherein pyrazolidine, hexahydro-pyridazine, (1,2)diazepane and 2,3,4,5, tetrahydro-1H-benzo(c)(1,2)diazepine are optionally substituted with one to three alkyl groups; or R 1 and R 4 together form —(CH 2 ) m —; m is 3, 4, 5 or 6; R 3 is cyclopropyl, arylcyclopropyl, isopropyl, tert.-butyl, adamantanyl or bicyclo(2.2.2)octyl, wherein adamantanyl and bicyclo(2.2.2)octyl are optionally substituted with one to three substituents independently selected from alkyl, hydroxy, halogen and haloalkyl; R 4 is hydrogen, alkyl, cycloalkyl, aryloxyalkyl, alkylcarbonylaminoaryloxyalkyl, alkyloxyalkyl, aryl, aralkyl, haloalkyl or halocycloalkyl; or R 3 and R 4 together form —(CH 2 ) n —; n is 3, 4, 5 or 6; and pharmaceutically acceptable salts and esters thereof; with the proviso that in case R 3 and R 4 together form —(CH 2 ) n — then R 1 is alkyl and R 2 is not hydrogen or alkyl; and with the proviso that in case R 4 is hydrogen or alkyl then R 3 is not isopropyl; and with the proviso that 3-cyclopropyl-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-one; 1,2-dihydro-5-methyl-4-tricyclo(3.3.1.13,7)dec-1-yl-3H-pyrazol-3-one; 1,2,3,4,6,7,8,9-octahydro-10H,12H-indazolo(1,2-a)indazole-10,12-dione; 1,2,4,5,6,7-hexahydro-1-methyl-2-phenyl-3H-indazol-3-one; 1,4,5,6-tetrahydro-1-methyl-2-phenyl-3(2H)-cyclopentapyrazolone; 1,4,5,6-tetrahydro-1-benzyl-2-phenyl-3(2H)-cyclopentapyrazolone; 1,4,5,6-tetrahydro-1-ethyl-2-(4-methyl)-phenyl-3(2H)-cyclopentapyrazolone; 1,4,5,6-tetrahydro-1-ethyl-2-phenyl-3(2H)-cyclopentapyrazolone; and 1,4,5,6,7,8-hexahydro-1-methyl-2-phenyl-3(2H)-cycloheptapyrazolone are excluded.