Patent ID: 7790738

Claim:
A method of reducing or alleviating T-cell dysfunction in a human with HIV infection or AIDS comprising administering a COX-2 inhibitor, or derivative or pharmaceutically acceptable salt thereof, which inhibits the enzymatic activity of COX-2, to a patient in need thereof, wherein the COX-2 inhibitor is a compound of general formula B: wherein Y represents oxazolyl, isoxazolyl, thienyl, dihydrofuryl, furyl, pyrrolyl, pyrazolyl, thiazolyl, imidazolyl, isothiazolyl, cyclopentenyl, phenyl or pyridyl; n is an integer from 0 to 3; m is an integer from 0 to 4; R 6 represents a ketocycly, cycloalkyl or aryl group, which group may optionally be substituted by one or more halogen atoms, or by a methyl group; R 7 each independently represent hydrogen, halogen atom, oxo group, acyl group, or alkyl group optionally substituted by one or more or more fluorine atoms; R 8 represents an alkyl group or —NHR 10 ; R 9 represents a halogen atom; and R 10 represents a hydrogen atom or an optionally substituted alkyl group; or a derivative or a pharmaceutically acceptable salt thereof.