Patent ID: 7534894

Claim:
A compound of the formula: or a pharmaceutically acceptable salt or ester form thereof; wherein: Ar is furanyl, thiophenyl, benzofuranyl, benzothiophenyl, indolyl, pyrazolyl or oxazolyl; R 1 is hydrogen, C 1 -C 6 alkyl or —(CH 2 ) r -phenyl; R 2 and R 3 are independently hydrogen, C 1 -C 6 alkyl, —(CH 2 ) p -phenyl, halogen or C 1 -C 3 perfluoroalkyl; R 4 is —CH(R 5 )(CO 2 H), tetrazole, —CH 2 -tetrazole, tetronic acid or a group of the formula: R 18 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, —CH 2 —(C 3 -C 6 cycloalkyl), —C 3 -C 6 cycloalkenyl, —CH 2 —(C 3 -C 6 cycloalkenyl), optionally substituted aryl, optionally substituted heteroaryl, optionally substituted —C 1 -C 6 alkyl-aryl, or optionally substituted —C 1 -C 6 alkyl-heteroaryl; R 5 is hydrogen or benzyl; n is 0 or 1; r is from 0 to 6; p is from 0 to 3 wherein Ar, alkyl, phenyl and benzyl groups are optionally substituted.