Patent ID: 7279576

Claim:
A compound of the formula wherein: R 1 is selected from the group consisting of: and W is CH thereof; each R 2 is individually selected from the group consisting of —H, alkyls, aminos, alkylaminos, arylaminos, cycloalkylaminos, halogens, alkoxys and hydroxys; each X and Y is individually selected from the group consisting of —O—, —S—, —NR 6 —, —NR 6 SO 2 —, —NR 6 CO—, alkynyls, alkenyls, alkylenes, —O(CH 2 ) h —, and —NR 6 (CH 2 ) h —, where each h is individually selected from the group consisting of 1, 2, 3, or 4, and where for each of alkylenes, —O(CH 2 ) h —, and —NR 6 (CH 2 ) h —, one of the methylene groups present therein may be optionally double-bonded to a side-chain oxo group except that with —O(CH 2 ) h —, the introduction of the side-chain oxo group does not form an ester moiety; A is a pyrimidyl; D is a phenyl; E is a phenyl; L is selected from the group consisting of —C(O)—, —S(O) 2 —, —N(R 6 )CO—, —N(R 6 )SO 2 —, —N(R 6 )CON(R 6 )—; each of m, n, p and q is 1; j is 0 or 1; t is 0 or 1; Q is selected from the group consisting of each R 4 group is individually selected from the group consisting of —H, alkyls, aminoalkyls, alkoxyalkyls, aryls, aralkyls, except when the R 4 substituent places a heteroatom on an alpha-carbon directly attached to a ring nitrogen on Q; each R 5 is individually selected from the group consisting of —H, alkyls, aryls, alkylaminos, arylaminos, cycloalkylaminos, hydroxys, alkoxys, aryloxys, alkylthios, arylthios, cyanos, halogens, perfluoroalkyl, alkylcarbonyls, and nitros; each R 6 is individually selected from the group consisting of —H, alkyls, allyls, and β-trimethylsilylethyl; each R 8 is individually selected from the group consisting of alkyls, and aralkyls; each R 9 group is individually selected from the group consisting of —H, —F, and alkyls, wherein when two R 9 groups are geminal alkyl groups, said geminal alkyl groups may be cyclized to form a 3-6 membered ring; G is selected from the group consisting of —O—, —S—, and —N(R 4 )—; k is 0 or 1; each Z is individually selected from the group consisting of —O— and —N(R 4 )—; and each ring of formula (I) optionally includes one or more of R 7 , where R 7 is a noninterfering substituent individually selected from the group consisting of—H, alkyls, aryls, alkylaminos, arylaminos, cycloalkylaminos, hydroxys, alkoxys, aryloxys, alkylthios, arthylthios, cyanos, halogens, nitros, alkylsulfinyls, alkylsulfonyls, aminosulfonyls, and perfluoroalkyls.