Patent ID: 7790759

Claim:
A compound of general formula I, wherein, R 1 is halogen, —OH, —OR 1 ′, —OCOR 1 ′, —OCOCH 2 CH 2 COOH, —OCOCH 2 CH 2 COOR 1 ′, —NH 2 , —NHR 1 ′, —N(R 1 ′) 2 , —NHCOR 1 ′, —O(CH 2 ) 1-3 COOH or —O(CH 2 ) 1-3 COOR 1 ′, wherein R l ′, is C 1 -C 5 -alkyl; R 2 is phenyl, or phenyl which is mono- or poly-substituted by halogen, hydroxyl, cyano, carboxyl, carboxy-C 1 -C 3 -alkyl, C 1 -C 8 -alkyl, amino, nitro, C 1 -C 8 -alkylamino or di(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkoxy, C 1 -C 5 -alkyl optionally substituted by halogen, or C 1 -C 8 -alkylcarbonyl; or 5- or 6-membered heterocyclic group containing sulphur, oxygen, or nitrogen as heteroatom, or 5- or 6-membered heterocyclic group which is mono- or poly-substituted by halogen, hydroxyl, cyano, carboxyl, carboxy-C 1 -C 3 -alkyl, C 1 -C 8 -alkyl, amino, nitro, C 1 -C 8 -alkoxy, or C 1 -C 8 -alkylcarbonyl group; X is CH 2 or C═O; and hydrogen in position 18 is in R— or S-stereoisomer; or a pharmaceutically acceptable salt thereof.