Patent ID: 7109332

Claim:
A compound having the formula: wherein R is a member selected from the group consisting of H and C 1-6 alkyl; R 1 is a member selected from the group consisting of H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-5 cycloalkyl and C 3-5 cycloalkyl-alkyl; R 2 is a member selected from the group consisting of H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, cyano and —C(O)R 2a , wherein R 2a is a member selected from the group consisting of C 1-6 alkoxy and (C 1-6 alkyl) 0.2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of —CH 2 —, —CH(CH 3 )—, —CH 2 CH 2 —, —CH 2 CH(CH 3 )— and —CH 2 CH 2 CH 2 —; L 1 is a linking group selected from the group consisting of a bond and —CH 2 —; L 2 is a linking group selected from the group consisting of a bond, —NH— and —CH 2 —; Ar 1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine, each of which is optionally substituted with from 1–2 R 3 substituents, wherein each R 3 is independently selected from the group consisting of halogen, cyano, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 3-5 cycloalkyl, C 3-5 cycloalkyl-alkyl, C 3-5 cycloalkyl-alkoxy, (C 1-6 alkyl) 0-2 amino, —C(O)R 3a , —O(CH 2 ) m OR 3b , —(CH 2 ) m OR 3b , —O(CH 2 ) m N(R 3b ) 2 and —(CH 2 ) m N(R 3b ) 2 , wherein the subscript m is an integer of from 1 to 3, each R 3a is a member independently selected from the group consisting of H, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, (C 1-6 alkyl) 0-2 amino, and each R 3b is a member independently selected from the group consisting of H, C 1-4 alkyl and C 1-4 alkanoyl, and optionally, two R 3b groups attached to nitrogen are combined with the nitrogen atom to form an azetidine, pyrrolidine or piperidine ring; AR 2 is a 5–6 membered monocyclic or 9–10 membered fused-bicyclic aromatic ring system, optionally having from 1 to 3 heteroatoms selected from N, O and S as ring vertices, said ring system being optionally substituted with from 1 to 3 R 4 substituents wherein each of said R 4 substituents is independently selected from the group consisting of halogen, cyano, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 3-5 cycloalkyl, C 3-5 cycloalkyl-alkyl, C 3-5 cycloalkyl-alkoxy, (C 1-6 alkyl) 0-2 amino and —C(O)R 4a , wherein each R 4a is a member independently selected from the group consisting of H, hydroxy, C 1-6 alkyl, C 1-6 alkoxy and (C 1-6 alkyl) 0-2 amino; the subscript t is 0 or 1 when L 2 is a bond, and is 1 when L 2 is selected from —NH— and —CH 2 — and when t is 0, then the moiety (AR2-L) 0 is H; or a pharmaceutically acceptable salt thereof.