Patent ID: 7365211

Claim:
A compound of Formula I: wherein: R 1 is CHR f R g , C 2-10 alkynyl, C 1-6 haloalkyl, halogen, cyano, —C(=Z)R o , —X 2 C(═O)X 1 R f , —NR f SO 2 R o , —N[C(═O)OR m ] 2 , —N═CR f NR j R k , —S(O) m R b , CONR i NHR o or C 1-10 alkyl wherein 2 or 3 nonadjacent carbon atoms in the alkyl chain can be replaced with —O—, —S— or —NR f , R 2 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-3 alkyl, C 1-3 alkoxycarbonyl-C 1-3 alkyl, C 1-6 haloalkyl, or aralkyl; R 3 is aryl or heteroaryl, each optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, halogen, haloalkyl, cyano, nitro, and —NR a″ R b″ , where R a″ and R b″ are each independently selected from the group consisting of hydrogen, C 1-9 alkyl, and C 1-9 alkylcarbonyl; R f is hydrogen or C 1-10 alkyl; R g is C 2-10 alkenyl, —NHNH 2 , cyano, —OC(═O)R f , —S(O) m R b or —X 2 (C═O)X 1 R f ; R h is C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, NR j R k or phenyl optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, haloalkyl, C 1-6 alkoxy, amino, alkylamino, dialkylamino, hydroxyalkyl, cyano, acylamino, alkylsulfonyl, alkylsulfonyloxy, and halogen; R i is R o , hydrogen, C 3-6 cycloalkyl or C 3-6 cycloalkyl-C 1-3 alkyl; R j and R k are (i) independently hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, or (ii) taken together along with the nitrogen atom to which they are attached are C 4-6 alkylene or (CH 2 ) 2 X 1 (CH 2 ) 2 ; R m is C 1-10 alkyl; R o is C 1-6 alkyl, C 2-6 alkenyl or phenyl optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, haloalkyl, C 1-6 alkoxy, amino, C 1-6 alkylamino, C 1-6 dialkylamino, hydroxyalkyl, cyano, acylamino, alkylsulfonyl, alkylsulfonyloxy, and halogen; X 1 and X 2 are independently —O— or —NR f1 — wherein at each occurrence R f1 is an independently selected R f radical, or if R f and R f1 are attached to the same nitrogen atom, R f and R f1 can, in addition, be taken together as C 4-6 alkylene or (CH 2 ) 2 X 1 (CH 2 ) 2 ; Z is O or NOR o ; m is an integer from 0 to 2; A 1 , A 2 and A 3 are independently CH or N with the proviso that at least two of A 1 , A 2 and A 3 are CH 4 ; and, individual isomers, racemic or non-racemic mixtures of isomers, solvates, hydrates or pharmaceutically acceptable salts thereof.