Patent ID: 7135181

Claim:
A method for reducing amyloid plaque burden in a mammal, the method comprising: administering an immunogenically effective amount of at least one modified Aβ or APP polypeptide, wherein said modified Aβ or APP polypeptide differs from the mammal's autologous Aβ or autologous APP polypeptide in that it comprises at least one isolated foreign T helper epitope inserted into said autologous Aβ or autologous APP polypeptide and wherein said at least one isolated T helper epitope is selected from the group consisting of a Tetanus toxoid epitope, a diphtheria toxoid epitope, an influenza virus hemagglutinin epitope, a P.falciparum CS epitope and an artificial MHC-II binding peptide sequence whereby administration to said mammal with said modified Aβ or APP polypeptide induces production of antibodies against the autologous Aβ or autologous APP polypeptide in said mammal.