Patent ID: 6953799

Claim:
A method of modulating metabolic distress in cells, comprising administering a therapeutically effective amount of a phthalazine dione or its pharmaceutically acceptable analog to cells in treating a condition selected from the group consisting of insulin resistance, hyperglycemia, hyper fatty acidemia, hyperinsulinemia, hypoadiponectinemia, Syndrome X, a condition associated with a regulatory gene defect, tumors associated with the p53 transcription factor, brain, or thymus, xeroderma pigmentosum, ataxia telangiectasia, trichothiodystrophy, Down's syndrome, burns, psoriasis, rheumatoid arthritis, leprosy and a neurological disorder, wherein said neurological disorder is selected from the group consisting of Parkinson's disease, Huntington's disease, Bloom's disease, amyotrophic lateral sclerosis, Cockayne syndrome and dementia.