Patent ID: 8715695

Claim:
A multimer of purified monomeric polypeptides, wherein said multimer is formed by 2-180 purified monomeric polypeptides via self-aggregation, and each said purified monomeric polypeptide is a polypeptide consisting of a fragment of an amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2, which fragment is selected from the group consisting of: 1) a polypeptide wherein the amino acid sequence of amino acid residues 414 to 660 from SEQ ID No:1, i.e., polypeptide 247; 2) a polypeptide wherein the amino acid sequence of amino acid residues 429 to 660 from SEQ ID No:1, i.e., polypeptide 232; 3) a polypeptide wherein the amino acid sequence of amino acid residues 439 to 660 from SEQ ID NO:1, i.e., polypeptide 222; and 4) a polypeptide wherein the amino acid sequence of amino acid residues 459 to 660 from SEQ ID NO:1, i.e., polypeptide 201.