Patent ID: 8632813

Claim:
A method of improving microcirculation in a replanted body part in a subject needing such treatment comprising the step of: applying directly to exposed tissues such as the vascular extima of blood vessels during surgery to reattach a severed body part or during wound treatment an effective amount of a semi-solid composition that comprises: a prostaglandin selected from the group consisting of prostaglandin E 1 , a pharmaceutically acceptable salt thereof, a C 1 to C 4 alkyl ester thereof and a mixture thereof; a penetration enhancer selected from the group consisting of an alkyl-(N-substituted amino) ester elected from the group consisting of an alkyl-(N-substituted amino)alkanoate, an alkyl-2-(N,N-disubstituted amino)alkanoate, an (N-substituted amino)alkanol alkanoate, an (N,N-disubstituted amino)alkanol alkanoate, a pharmaceutically acceptable salt thereof and a mixture thereof; a shear-thinning polymer thickener selected from the group consisting of a shear-thinning polysaccharide gum and a shear-thinning polyacrylic acid polymer; a lipophilic component that is selected from the group consisting of an aliphatic C 1 to C 8 alcohol, an aliphatic C 8 to C 30 ester, a liquid polyol and a mixture thereof; water and a buffer system that provides a buffered pH value for said composition in the range of about 3 to about 7.4.