Patent ID: 8372952

Claim:
A binding protein that selectively binds β-Klotho and Fibroblast Growth Factor Receptor 1c (“FGFR1c”) comprising (a) one or more domains that selectively bind β-Klotho, and (b) one or more domains that selectively bind FGFR1c, wherein the binding protein comprises: (a) a β-Klotho binding domain comprising: (SEQ ID NO: 257) CGADQFRCGNGSCVPRAWRCDGVDDCGDGSDEAPEIC; (b) an FGFR1c binding domain comprising: (SEQ ID NO: 108) CG [AE][GS] LFTC [GR][NRS][AST][KN] ICIS [EHQS][AV]W [IV] CDG [IV] DDC [DE] DNSDE [DKMNT][NSY] C , wherein the FGFR1c binding domain retains the ability to bind FGFR1c; and wherein amino acids in brackets indicate alternative amino acids at a specified position and “−” indicates no amino acid at the specified position.