Patent ID: 7964724

Claim:
A compound of the formula I and the pharmaceutically acceptable salts and esters thereof, wherein X 1 is selected from the group consisting of lower alkoxy, and lower alkoxy substituted by trifluoromethyl or fluorine; X 2 is C(X 4 X 5 )—X 6 ; X 3 is selected from the group consisting of hydrogen, lower alkoxy and halogen: X 4 and X 5 are lower alkyl or together form a cycloalkyl; X 6 is selected from the group consisting of lower alkyl, cyano, —CH 2 —OH, —CH 2 —O-lower alkyl, —CH 2 —O-lower alkyl substituted by lower alkoxy, —C(O)X 7 , and —CH 2 —NX 8 X 9 ; X 7 is selected from the group consisting of hydroxy, lower alkoxy, morpholino, and —NX 8 X 9 ; X 8 and X 9 are independently selected from the group consisting of hydrogen, lower alkyl, lower alkyl substituted by lower alkoxy or cyano, and lower alkoxy; Y 1 and Y 2 are independently selected from the group consisting of halogen, cyano, and acetylene; R is wherein n=1 or 2, R 1 is lower alkyl substituted by R 2 ; R 2 is selected from the group consisting of lower alkoxy, trifluoromethyl, -cyano, —NH—SO 2 -lower alkyl, —NH—C(O)-lower alkyl, —C(O)R 4 , —C(O)—NX 8 X 9 , —SO 2 -lower alkyl and —SO 2 —NX 8 X 9 ; and R 4 is selected from the group consisting of hydroxy, lower alkoxy, morpholino, and —NX 8 X 9 and wherein the absolute stereochemistry at the 4 and 5 position of the imidazoline ring is S and R respectively.