Patent ID: 8623345

Claim:
A conjugate having a formula wherein: W is a covalently conjugated drug or detectable label; corresponds to a single or double bond; R x is hydrogen or optionally substituted C 1-6 alkyl; Z is an optionally substituted bivalent C 1-10 hydrocarbon chain, wherein 1, 2, 3, 4 or 5 methylene units of Z are optionally and independently replaced with one or more groups selected from the group consisting of —S—, —O—, —NR a —, —(C═NR a )—, —(C═O)—, —(S═O)—, —S(═O) 2 —, —(CR b ═CR b )—, —(N═N)—, an optionally substituted arylene moiety and an optionally substituted heteroarylene moiety, wherein R a is hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, optionally substituted heteroaryl, or a suitable amino protecting group; and R b is hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, or an optionally substituted heteroaryl; each instance of X is independently —OR c or —N(R d ) 2 , wherein R c is hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, optionally substituted heteroaryl, a suitable hydroxyl protecting group, a cation group, or an affinity ligand, and each R d is, independently, hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, optionally substituted heteroaryl, a suitable amino protecting group, or an affinity ligand, wherein at least two occurrences of X include an affinity ligand; Y is hydrogen, halogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, optionally substituted heteroaryl, —OR e or —SR e wherein R e is hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, or an optionally substituted heteroaryl; n is an integer from 5 to 25; and the group: corresponds to a mixture of the groups: wherein the sum of (m+p) is equal to n.