Patent ID: 8513412

Claim:
A compound of Formula I and pharmaceutically acceptable salts thereof: wherein: A is wherein R 1a is i-propyl, R 2a is —S(O) 2 Me, R 3a is methyl and R 4a 4-fluorophenyl; R 5 and R 6 are independently selected and R 5 is selected from the group consisting of: hydrogen, C 1-6 haloalkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, C 1-6 alkyl aryl, C 1-6 alkanoyl aryl, heteroaryl, C 1-6 alkanoyl heteroaryl and C 1-6 alkyl heteroaryl; and R 6 is selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, C 1-6 alkanoyl aryl, heteroaryl, C 1-6 alkanoyl heteroaryl and C 1-6 alkyl heteroaryl; provided always that R 5 is not benzyl or H when R 6 is methyl; R 7 and R 8 are independently selected from the group consisting of: C 1-4 alkyl and halo; X is —(CR a R b ) m (CR a ═CR b ) n (CR a R b ) o — where R a and R b are independently selected from the group consisting of: H, methyl, ethyl and halo and m, n, and o are independently 0, 1, 2, or 3 provided that m+n+o is not more than 3; and wherein each of the above R groups may, where chemically possible, be independently optionally substituted by from 1 to 5 groups chosen independently at each occurrence from the group consisting of: halo, C 1-3 alkyl, halo C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, hydroxy, and cyano.