Patent ID: 8741350

Claim:
A taste masked multi-layered particle comprising: a) an inert core, b) one or more coating layer(s), wherein at least one coating layer comprises a pharmaceutically active ingredient and a binder, c) an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound and comprising a water-soluble pharmaceutical film-forming compound, selected from the group consisting of hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), poly(1-vinylpyrrolidin-2-one) (PVP), and any combination thereof, and d) an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound and comprising: (i) a poly(meth)acrylate or (ii) a mixture comprising 60-90% (w/w) ethylcellulose (EC) and 10-40% (w/w) hydroxypropyl methylcellulose (HPMC), wherein the pharmaceutically active ingredient is water-soluble and comprises either at least one basic group and/or a bitter taste.