Patent ID: 8440662

Claim:
A compound of formula (I): wherein: R 1 is H, F, Cl, or OCH 3 ; R 2 is H, optionally substituted aryl, optionally substituted heterocycle, optionally substituted heteroaryl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkylamino, optionally substituted dialkylamino, optionally substituted arylamino, optionally substituted heteroarylamino, optionally substituted heterocycle-amino, optionally substituted alkylcarbonylamino, optionally substituted alkylsulfonylamino, optionally substituted alkylthio, optionally substituted alkylsulfonyl, optionally substituted alkoxy, optionally substituted hydroxyalkyl, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycle-oxy, optionally substituted alkylaminocarbonyl, optionally substituted arylaminocarbonyl, optionally substituted heteroarylaminocarbonyl, optionally substituted heterocycle-aminocarbonyl, or C(O)-(optionally substituted heterocycle) and R 3 is H, halogen, CN, OH, NH 2 , NHCH 3 , or OCH 3 ; or R 2 is H, halogen, CN, OH, NH 2 , NHCH 3 , or CH 3 , and R3 is H, optionally substituted aryl, optionally substituted heterocycle, optionally substituted heteroaryl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkylamino, optionally substituted dialkylamino, optionally substituted arylamino, optionally substituted heteroarylamino, optionally substituted heterocycle-amino, optionally substituted alkylcarbonylamino, optionally substituted alkylsulfonylamino, optionally substituted alkylthio, optionally substituted alkylsulfonyl, optionally substituted alkoxy, optionally substituted hydroxyalkyl, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycle-oxy, optionally substituted alkylaminocarbonyl, optionally substituted arylaminocarbonyl, optionally substituted heteroarylaminocarbonyl, optionally substituted heterocycle-aminocarbonyl, or C(O)-(optionally substituted heterocycle); R 4 is optionally substituted morpholine or thiomorpholine; R 5 is H, F, or Cl; R 6 is H, F or Cl; M is selected from the group consisting of: R 7 and R 8 are, independently, H, or optionally substituted alkyl; or R 7 and R 8 are joined to form an optionally-substituted heterocycle containing 1 or 2 nitrogen atoms, 0 or 1 oxygen atom, 0 or 1 sulfur atom, 0 or 1 S(O) fragment, 0 or 1 S(O) 2 fragment, and 3 to 6 carbon atoms; R 9 is H or alkyl; R 10 is H or alkyl optionally substituted with OH, NH 2 , NHCH 3 , N(CH 3 ) 2 , halogen, alkoxy, CF 3 , OCF 3 , or CN; or R 9 and R 10 are joined to form an optionally-substituted heterocycle wherein the fragment —R 9 —R 10 — is optionally substituted —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, or —CH 2 CH 2 CH 2 CH 2 CH 2 —; A is CH or C—F; X is N, CH, C—F or C—Cl; Y is N, CH, C—F or C—Cl; and Z is N, CH, C—F, or C—Cl; or a pharmaceutically acceptable salt or solvate thereof.