Patent ID: 6908996

Claim:
A compound of Formula IIA: wherein: R is a carboxylic acid protecting group; R 1 is a group of the formula; R 2 is C 2 -C 4 alkenylene, C 2 -C 4 alkylene, 1,2-phenylene, or 1,2-cyclohexenylene; R 2 ′ is C 1 -C 3 alkyl, C 1 -C 6 haloalkyl, C 1 -C 3 alkoxy, or 2,2,2-trichloroethoxy; R 3 is hydrogen, C 1 -C 3 alkyl, halomethyl, cyanomethyl, 3-(2-chlorophenyl)-5-methylisoxazol-4-yl, benzyloxy, 4-nitrobenzyloxy, 2,2,2-trichloroethoxy, tert-butoxy, 4-methoxybenzyloxy, phenyl, substituted phenyl, a group of the formula R 0 -(Q) m -CH 2 —, a heteroarylmethyl group of the formula R″CH 2 —, or a substituted group of the formula R 0 is phenyl, substituted phenyl, 2-thienyl, 3-thienyl, or 1,4-cyclohexyldienyl; R″ is 2-furyl, 3-furyl, 2-thiazolyl, or 5-isoxazolyl; m is 0 or 1, Q is O or S; W is protected hydroxy, or protected amino; Y is hydrogen, acetyl, or nitroso; R 10 is C 1 -C 6 alkyl, C 1 -C 6 polyfluoroalkyl, C 3 -C 6 cycloalkyl, adamantyl, phenyl, substituted phenyl, phenyl(C 1 -C 3 alkyl), diphenylmethyl, or substituted phenyl(C 1 -C 3 alkyl), or a group of the formula Z is solid polymer support; and Z 1 is one or two groups independently selected from the group consisting of hydrogen, halo, hydroxy, protected hydroxy, nitro, cyano, trifluoromethyl, C 1 -C 4 alkyl, and C 1 -C 4 alkoxy.