Patent ID: 7794748

Claim:
A stable oral solid drug composition in solid dosage form comprising: ramosetron or a pharmaceutically acceptable salt thereof; and more than one member selected from the group consisting of following (i) to (vii): (i) an aliphatic carboxylic acid consisting of maleic acid, malonic acid, succinic acid, and fumaric acid, or an ester thereof, (ii) a hydroxycarboxylic acid consisting of tartaric acid, maleic acid, and citric acid or an ester thereof; (iii) an acidic amino acid consisting of aspartic acid or glutamic acid; (iv) an enolic acid consisting of ascorbic acid or erythorbic acid; (v) an aromatic carboxyl compound consisting of phthalic acid or propyl gallate or an ester thereof; and (vi) a carboxyl group-containing high-molecular substance consisting of carboxymethyl cellulose or alginic acid, (vii) one or more additives selected from the group consisting of excipients, binders, disintegrating agents, sour agents, blowing agents, artificial sweeteners, flavors, lubricants and coloring agents, wherein tartaric acid, maleic acid, or citric acid, or an ester thereof, is present in the composition; the one more members (i) to (vi) are present in an amount of 0.01 to 90 percent by weight based on total weight of the composition; and ramosetron or its pharmaceutically acceptable salt is present in an amount of 0.002 to 0.02 mg based on total weight of the composition.