Patent ID: 7411057

Claim:
An isolated nucleic acid molecule encoding an anti-CTLA-4 antibody, wherein said isolated nucleic acid molecule encodes a heavy chain and a light chain, wherein the immunoglobulin heavy chain complementarity determining region (CDR) CDR1 comprises from amino acid 26 to amino acid 35 of SEQ ID NO:70, the CDR2 comprises from amino acid 50 to amino acid 64 of SEQ ID NO:70, and the CDR3 comprises from amino acid 99 to amino acid 114 of SEQ ID NO:70, and further wherein the immunoglobulin light chain CDR1 comprises from amino acid 24 to amino acid 34 of SEQ ID NO:71, the CDR2 comprises from amino acid 50 to amino acid 56 of SEQ ID NO:71, and the CDR3 comprises from amino acid 89 to amino acid 97 of SEQ ID NO:71.