Patent ID: 7579334

Claim:
A compound according to Formula I: wherein M represents the macrolide subunit of the substructure II: wherein R 1 , R 2 , R 3 , R 4 and R 5 are, chosen independently of each other, from the group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 10 alkanoyl, C 1 -C 10 alkoxycarbonyl, C 6 -C 14 arylmethoxycarbonyl, C 6 -C 14 aroyl, C 6 -C 14 arylalkyl, C 1 -C 10 alkylsilyl and C 1 -C 10 alkylsilylalkoxyalkyl; R N represents the covalent link with X 1 of the chain L; L represents the chain of the substructure III: —X 1 —(CH 2 ) m -Q-(CH 2 ) n —X 2 — III wherein X 1 is —CH 2 — or —C(O)—; X 2 is —NH— or —O—; Q is —NH— or —CH 2 —; symbols m and n, independently, are whole numbers from 0 to 4; with the proviso that if Q=NH, n cannot be 0; wherein D is a steroid of the substructure IV: wherein R a and R b are chosen independently of each other from the group consisting of hydrogen and halogen; R f is chosen from the group consisting of hydrogen, hydroxyl group, halogen or R f forms a carbonyl group with the carbon atom to which it is linked; R c is a covalent link with X 2 of the chain L; R d and R e are chosen independently from the group consisting of hydrogen, hydroxy, methyl, C 1 -C 4 alkoxy or R d and R e together with the pertaining C-atoms to which they are attached represent 1,3-dioxolane ring which can be additionally mono or di-substituted with C 1 -C 10 alkyl or C 2 -C 10 alkenyl; and R j is chosen from the group consisting of hydrogen and chlorine; or a pharmaceutically acceptable salt thereof.