Patent ID: 8080576

Claim:
A compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof, wherein each Ar is independently an aromatic group optionally substituted with 1 to 4 substituents; each A is independently selected from C═O, C═S, and SO 2 ; or A is optionally a covalent bond when adjacent to an occurrence of Z; B is absent or is N(R 9 )R 10 ; L is absent; M is absent or is C 1-12 alkyl; Q is absent; X is selected from O, S, NH, and N—C 1-6 alkyl; Y is absent or is selected from C═O and SO 2 ; each Z is independently selected from O, S, NH, and N—C 1-6 alkyl; or Z is optionally a covalent bond when adjacent to an occurrence of A; R 1 is selected from H, —C 1-6 alkyl-B, C 1-6 hydroxyalkyl, C 1-6 alkoxyalkyl aryl, and C 1-6 aralkyl; R 2 and R 3 are each independently selected from aryl, C 1-6 aralkyl, heteroaryl, and C 1-6 heteroaralkyl; R 4 is N(R 5 )L-Q-R 6 ; R 5 is hydrogen; R 6 is selected from hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, Ar—Y—, carbocyclyl, heterocyclyl, an N-terminal protecting group, aryl; C 1-6 aralkyl, R 11 ZAZ—C 1-8 alkyl-, R 14 Z—C 1-8 alkyl-, (R 11 O)(R 12 O)P(═O)O—C 1-8 alkyl-ZAZ—C 1-8 alkyl-, R 11 ZAZ—C 1-8 alkyl-ZAZ—C 1-8 alkyl-, heterocyclylMZAZ—C 1-8 alkyl-, (R 11 O)(R 12 O)P(═O)O—C 1-8 alkyl-, (R 13 ) 2 N—C 1-12 alkyl-, (R 13 ) 3 N + —C 1-12 alkyl-, heterocyclylM-, carbocyclylM-, R 14 SO 2 C 1-8 alkyl-, and R 14 SO 2 NH; or R 5 and R 6 together are C 1-6 alkyl-Y—C 1-6 alkyl, C 1-6 alkyl-ZAZ—C 1-6 alkyl, ZAZ—C 1-6 alkyl-ZAZ—C 1-6 alkyl, ZAZ—C 1-6 alkyl-ZAZ, or C 1-6 alkyl-A, thereby forming a ring; R 7 and R 8 are independently selected from hydrogen, C 1-6 alkyl, and C 1-6 aralkyl; R 9 is selected from hydrogen, OH, and C 1-6 alkyl; and R 10 is an N-terminal protecting group; R 11 and R 12 are independently selected from hydrogen, metal cation, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, aryl, and C 1-6 aralkyl; each R 13 is independently selected from hydrogen and C 1-6 alkyl; and R 14 is independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, carbocyclyl heterocyclyl, aryl, and C 1-6 aralkyl; and R 15 is selected from C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, —C(O)OC 1-6 alkyl,—C(O)NH C 1-6 alkyl, and C 1-6 aralkyl; provided that in any occurrence of the sequence ZAZ, at least one member of the sequence must be other than a covalent bond.