Patent ID: 7371875

Claim:
A compound of formula I: wherein: R 1 is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl and substituted aryl; R 2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl and substituted aryl; X and X′ are independently selected from the group consisting of oxygen, sulfur and NR 3 where R 3 is independently selected from the group consisting of hydrogen, hydroxyl, amino, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkoxy, aryloxy, alkylamino, arylamino, and acylamino; Y is selected from the group consisting of —O—, —N(R 3 )—, —S— and —C(R 4 )(R 5 )—; Y′ is —N(R 3 )—; and Y″ is —O—; wherein: R 3 is as defined above and R 4 and R 5 are independently selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, substituted aryloxy, acyloxy, amino, substituted amino, acylamino, alkylthio, arylthio, and acylthio or R 4 and R 5 together with the carbon atom pendent thereto form an optionally substituted cycloalkyl group or further R 4 and R 5 together with the carbon atom pendent thereto form an optionally substituted vinyl group; or prodrugs, isomers and pharmaceutically acceptable salts thereof.