Patent ID: 7282596

Claim:
A method for preparing a compound having a formula (II-b): wherein R′ is an aryl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of halogen atom, C 1 -C 6 alkyl, and C 6 -C 10 aryl group; X is C 1 -C 6 alkyl, thiazol, imidazole, pyrrolidine, thiophene, oxazole or a phenyl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of C 1 -C 5 alkyl, C 1 -C 4 alkoxy, trifluoromethyl group, C 1 -C 3 aliphatic acylamino group, nitro group, halogen atom, and phenyl group; and is a triple bond or a double bond in the cis or trans position; comprising the following steps: (a) reacting a Protected-Corey aldehyde as shown below, wherein R′ is defined as above; with a Phosphonate compound as shown below, wherein R″ is C 1 -C 6 alkyl; X and are defined as above; to form the following formula (II-a) compound: wherein R′, X and are defined as above; and (b) reducing the formula (II-a) compound to form the formula (II-b) compound wherein R′, X and are defined as above.