Patent ID: 7838637

Claim:
A single-chain multiple antigen-binding molecule comprising: (a) a variable domain of a heavy chain of an immunoglobulin (VH) with a first specificity (A), or functional parts thereof, (b) a variable domain of a light chain of an immunoglobulin (VL) with a second specificity (B), or functional parts thereof, (c) a variable domain of a heavy chain of an immunoglobulin (VH) with the specificity (B), or functional parts thereof, and (d) a variable domain of a light chain of an immunoglobulin (VL) with the specificity (A), or functional parts thereof, wherein the VH and VL domains are connected in the form of a VH-VL construct or VL-VH construct, and wherein the two VH-VL or VL-VH constructs are connected via a peptide (P) that connects variable domains with the same specificity, and wherein the first specificity (A) is different than the second specificity (B) and wherein the VH and VL domains are connected via a peptide linker (L) in the form of a VH-L-VL construct or VL-L-VH construct, wherein the linker (L) is about 1-20 amino acids long, and peptide (P) is 12 amino acids or longer.