Patent ID: 7125837

Claim:
A pharmaceutical composition that provides an elastin-based composition for localized delivery in vivo, said elastin-based composition consisting of a polypeptide, wherein said polypeptide consists of (i) an amino acid sequence at least 95% identical to SEQ ID NO: 3, (ii) an amino acid sequence represented by SEQ ID NO: 2, or (iii) a peptide fragment of six repeats of the hexameric sequence represented by SEQ ID NO: 1, wherein said elastin-based composition is attached to a biocompatible support or dissolved in a biocompatible matrix and has one or more biological activities selected from the group consisting of: a) inhibiting the proliferation of smooth muscle cells in vivo; b) stimulating the differentiation of smooth muscle cells in vivo; c) regulating the migration of smooth muscle cells in vivo; and d) binding to smooth muscle cells, and wherein said elastin-based composition has an IC50/EC50 for at least one of said biological activities that is less than or equal to 10 −3 .