Patent ID: 8101610

Claim:
A method for inhibiting hedgehog signaling in a cell comprising contacting said cell with a compound of formula I: wherein ring A is benzene; ring B is pyridine, pyrazine, pyrimidine, 1,2,4-triazine, thiophene, thiazole, imidazole, pyrrole or pyrazole; carbocycle is a mono-, bi-, or tricyclic aliphatic ring having 3 to 14 carbon atoms which is saturated or unsaturated, aromatic or non-aromatic; heterocycle is a mono-, bi-, or tricyclic, saturated or unsaturated, aromatic or non-aromatic ring having from 5 to about 14 ring atoms, where the ring atoms are 1 to 4 nitrogen, sulfur or oxygen heteroatoms and the balance carbon atoms; R 1 is hydroxyl, halogen, amino, nitro, cyano, alkyl, acyl sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl or sulfonamide; wherein said amino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl and sulfonamide substituent is optionally substituted with amino, halogen, hydroxyl, oxo, or is substituted with a carbocycle or heterocycle, as defined above, that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; or R 1 is a carbocycle or a heterocycle, as defined above, that is optionally substituted with hydroxyl, halogen, amino, nitro, cyano, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl, sulfonamide, a carbocycle or heterocycle, as defined above; wherein said amino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, oxo, or is substituted with a carbocycle or heterocycle, as defined above, that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; R 2 is hydrogen; R 3 is Me, F, Cl, —CH 2 —SO 2 -Me, —SO 2 -Me, 1H-1,2,4-triazol-1-yl, 1H-imidazol-1-yl, morpholino, thiomorpholino-methyl with S in the oxidized form SO 2 , 1,2,3-thiadiazol-4-yl or N-methyl-piperizinyl; each R 4 is independently H or alkyl; R 5 is chloro; m is 0-3; n is 0-4; or a salt or solvate thereof.