Patent ID: 8198292

Claim:
A method of promoting bone growth in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I: wherein each of R 1 , R 2 , R 5 , R 7 and R 8 are independently selected from the group consisting of H, halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkoxy, C 1-6 alkyl-hydroxy, —OR 1a , —C(O)R 1a , —C(O)OR 1a , —C(O)NR 1a R 1b , —NR 1a R 1b , —SR 1a , —N(R 1a )C(O)R 1b , —N(R 1a )C(O)OR 1b , —N(R 1a )C(O)NR 1a R 1b , —OP(O)(OR 1a ) 2 , —S(O) 2 OR 1a , —S(O) 2 NR 1a R 1b , —CN, —CH═N—OH, C 1-6 alkyl-OC(O)-aryl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl; alternatively, R 1 is combined with R 2 to form ═O or ═NR 1a , R 1 is combined with R 3 to form a bond, or R 1 is combined with R 5 to form a cycloalkyl; each R 1a and R 1b is independently selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkyl-hydroxy, C 1-6 alkyl-NO 2 , C 1-6 alkyl-cycloalkyl, heterocycloalkyl, and heteroaryl; each of R 3 and R 4 are independently selected from the group consisting of H, C 1-6 alkyl and C 1-6 haloalkyl; alternatively two R 5 or R 7 groups attached to the same carbon can be combined to form ═O; R 6 is absent or an N-oxide; and salts, hydrates and isomers thereof, thereby promoting bone growth in the subject.