Patent ID: 8318952

Claim:
A method for treating asthma, said method comprising: administering to a mammal an effective amount of a compound of formula (I-b), wherein: R 1 and R 2 are each —COOH -D-R 1 is C1-4 alkylene-R 1 , E is a bond or C1-4 alkylene, ring A is a benzene ring which may optionally be substituted by group(s) selected from the group consisting of (1) hydroxy, (2) methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl, each of which may optionally be substituted by 1-4 of halogen, (3) methoxy, ethoxy, n-propyloxy, isopropyloxy, n-butyloxy, isobutyloxy, sec-butyloxy, or tert-butyloxy, (4) amino, (5) nitro and (6) halogen, ring B is a pyrrole ring which may optionally be substituted by group(s) selected from the group consisting of (1) hydroxy, (2) methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl, each of which may optionally be substituted by 1-4 of halogen, (3) methoxy, ethoxy, n-propyloxy, isopropyloxy, n-butyloxy, isobutyloxy, sec-butyloxy, or tert-butyloxy, (4) amino, (5) nitro and (6) halogen, Y and Z are each a carbon atom, the ring of the formula is 1H-indole ring, W is —O—CH 2 —, —O—(CH 2 ) 2 —, —O—(CH 2 ) 3 —, —O—(CH 2 ) 4 —, —O—(CH 2 ) 5 —, —CH 2 —O—, —(CH 2 ) 2 —O—, —(CH 2 ) 3 —O—, —(CH 2 ) 4 —O—, —(CH 2 ) 5 —O—, —O—(CH 2 ) 3 —O—, —O—(CH 2 ) 4 —O—, —O—(CH 2 ) 5 —O—C1-6 alkylene or —CH 2 —O—(CH 2 ) 3 —, V is (wherein R 110 is hydrogen or C1-8 alkyl, and the arrow means that it attaches to the ring A), ring 1 is a benzene ring which may optionally be substituted by group(s) selected from the group consisting of C1-10 straight or branched alkyl, alkenyl and alkynyl group, and ring 2 is a benzene ring which may optionally be substituted by group(s) selected from the group consisting of hydroxy, methyl, ethyl, propyl, n-butyl, n-pentyl, n-hexyl, fluorine, chlorine, bromine, methoxy, ethoxy, propoxy, butoxy, trifluoromethyl and methylthio, or a pharmaceutical acceptable salt thereof.