Patent ID: 6982260

Claim:
A compound of Formula I: wherein, R 1 is hydrogen, alkyl, alkyl substituted with at least one of amine, halogen, hydroxy, or alkoxy, cycloalkyl, or 4–10 membered heterocyclyl having 1–3 heteroatoms selected from O, S or N; R 2 is OH, alkyloxy, aryloxy, or NR 3 R 4 ; A is N, or CW 3 ; R 3 and R 4 are independently hydrogen, alkyl, alkenyl, alkynyl, (CH 2 ) n Ar, cycloalkyl, 4–10 membered heterocyclyl having 1–3 heteroatoms selected from O, S, or N, or a 4–9 membered heteroaryl having 1–4 heteroatoms selected from O, S or N, or R 3 and R 4 together with the nitrogen to which they are attached optionally may form a ring having 3 to 7 carbon atoms and said ring optionally contains 1, 2 or 3 heteroatoms selected from the group consisting of nitrogen, substituted nitrogen, oxygen and sulfur including S(O) and S(O) 2 , said ring also may be additionally substituted with up to 3 groups selected from alkyl, haloalkyl, NR 8 C(O)R 9 , C(O)OR 8 , C(O)R 8 , C(O)NR 8 R 9 , NR 8 R 9 , NR 8 SO 2 R 9 , OR 8 , SO 2 NR 3 R 4 , or SR 8 ; W 1 and W 2 are independently selected from NR 3 R 4 , N(O)R 3 R 4 , NR 3 R 4 X, OR 3 , SR 3 , hydrogen, halogen, haloalkyl, COR 3 , CO 2 R 3 , CONR 3 R 4 , S(O)R 3 , SO 2 R 3 , SO 2 NR 3 R 4 , SO 3 R 3 , P(O)(OR 3 ) 2 , CHO, CN, nitro, alkyl, T(CH 2 ) m QR 8 , C(O)T(CH 2 ) m QR 8 , or T(CH 2 ) m CO 2 R 8 where m is 1–6, T is O, S, NR 3 , N(O)R 3 , NR 3 R 4 X, or CR 3 R 4 , and Q is O, S, NR 9 , N(O)R 9 or NR 9 R 10 X, or NR 9 C(O)T(CH 2 ) m QR 9 ; R 5 is hydrogen, or alkyl; R 6 is hydrogen, alkyl, halogen, haloalkyl, alkynyl, alkenyl, COR 3 , CO 2 R 3 , CONR 3 R 4 , SO 2 NR 3 R 4 , SO 2 R 3 , SO 3 R 3 , P(O)(OR 3 ) 2 , aldehyde, nitrile, nitro, OR 3 , or NR 3 R 4 W 3 is hydrogen, NR 3 R 4 , N(O)R 3 R 4 , NR 3 R 4 R 8 X, OH, OR 3 , SH, SR 3 , halogen, COR 3 , CO 2 R 3 , CONR 3 R 4 , S(O)R 3 , SO 2 R 3 , SO 2 NR 3 R 4 , SO 3 R 3 , (CH 2 ) n P(O)(OR 3 ) 2 , NR 3 SO 2 R 4 , aldehyde, nitrile, nitro, alkyl, T(CH 2 ) m QR 8 , C(O)T(CH 2 ) m QR 8 , NR 8 C(O)T(CH 2 ) m QR 11 , or T(CH 2 ) m CO 2 R 3 where m and n are independently 1–6, T is O, S, NR 3 , N(O)R 3 , or CR 3 R 4 , and Q is O, S, NR 9 , N(O)R 9 or NR 9 R 10 X; R 8 , R 9 , R 10 and R 11 are hydrogen, alkyl, or aryl; X is a halogen; or a pharmaceutically acceptable salt thereof.