Patent ID: 8680073

Claim:
A method of making a sterile pharmaceutical composition packaged in a syringe, comprising an admixture of a hyaluronic acid related component (HARC) and a pharmaceutically effective amount of triamcinolone hexacetonide (TAH), the method comprising mixing the HARC with the triamcinolone hexacetonide (TAH) to form an HARC/TAH mixture, the HARC comprising DVS-cross linked hyaluronic acid, packaging said HARC/TAC mixture in a syringe, subjecting the mixture to heat sterilization to form a sterile admixture, and storing said syringe containing said sterile admixture, said composition exhibiting both following characteristics a) and b) when compared in an accelerated shelf-life test to a control composition having said HARC but lacking TAH, said accelerated shelf-life test comprising heating at 80° C. for 24 hours: a) the change in the elastic modulus (ΔG′) of the composition is no more than 10% greater than ΔG′ of the control composition; b) the change in the viscosity (Δη) of the composition is no more than 10% greater than Δη of the control composition, said composition having a viscosity between 20 Pas and 100 Pas.