Patent ID: 7858645

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein: X is —NH—C(O)—; Y is —(CR 9 R 10 ) n —, wherein R 9 and R 10 independently from each other are selected from the group consisting of hydrogen, lower alkyl, fluoro-lower-alkyl, lower-alkoxy, and fluoro-lower-alkoxy; and n is 0 or 1; R 1 , R 2 , R 3 and R 4 independently from each other are selected from the group consisting of: (1) hydrogen, (2) halogen, (3) lower-alkyl, (4) fluoro-lower-alkyl, (5) lower-alkoxy, (6) fluoro-lower-alkoxy, (7) carbamoyl, (8) lower-alkyl-NH—C(O)—NH, (9) aryl-lower-alkyl-NH—C(O)—NH, and (10) lower-alkyl-SO 2 —NH-lower-alkyl; R 5 is phenyl or a heteroaryl selected from the group consisting of (a) thiophenyl, (b) pyridinyl, (c) furanyl, and (d) thiazolyl, which phenyl or heteroaryl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of: (1) halogen, (2) lower-alkyl, (3) fluoro-lower-alkyl, (4) lower-alkoxy, (5) fluoro-lower-alkoxy, (6) hydroxy, (7) HO—SO 2 , (8) NH 2 —SO 2 , (9) N(H,lower-alkyl)-SO 2 , (10) N(lower-alkyl) 2 -SO 2 , (11) lower-alkyl-SO 2 —NH, (12) carboxy, (13) carboxy-lower-alkyl, (14) carboxy-lower-alkoxy, (15) NO 2 , (16) CN, (17) NH 2 , (18) N(H,lower-alkyl), (19) N(lower-alkyl) 2 , (20) NH 2 C(O), (21) N(H,lower-alkyl)C(O), (22) N(lower-alkyl) 2 C(O), (23) lower-alkyl-C(O)NH, (24) 1H-tetrazol-5-yl, and (25) 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; R 6 is wherein: (a) R 11 and R 12 independently from each other are selected from the group consisting of hydrogen, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, and fluoro-lower-alkoxy; (b) R 13 , R 14 and R 15 independently from each other are selected from the group consisting of hydrogen, lower-alkyl, halogen, fluoro-lower-alkyl, lower-alkoxy, hydroxy, fluoro-lower-alkoxy, NO 2 and NH 2 —C(O); and (c) R 16 is hydrogen or lower-alkoxy; with the proviso that the compound of formula (I) is not: N-[1-(phenylmethyl)-1H-indazol-3-yl]-benzamide, 4-methyl-N-[1-(phenylmethyl)-1H-indazol-3-yl]-benzamide, 4-nitro-N-[1-(phenylmethyl)-1H-indazol-3-yl]-benzamide, 4-chloro-N-[1-(phenylmethyl)-1H-indazol-3-yl]-benzamide, 4-methoxy-N-[1-(phenylmethyl)-1H-indazol-3-yl]-benzamide, N-[1-(phenylmethyl)-1H-indazol-3-yl]-benzenacetamide, or N-(1-ethyl-1H-indazol-3-yl)-benzamide.