Patent ID: 8426594

Claim:
A compound of Formula I: wherein R 1 and R 2 are each independently selected from the group consisting of —(C 1 -C 10 )alkyl, —(C 2 -C 10 )alkenyl, —(C 2 -C 10 )alkynyl, —(C 3 -C 12 )cycloalkyl, —(C 3 -C 12 )cycloalkenyl, —(CH 2 ) n —O—(CH 2 ) n —CH 3 , (C 1 -C 10 )alkoxy, C(halo) 3 , —CH(halo) 2 , —CH 2 (halo), C(O)R 6 , —C(O)O—(C 1 -C 10 )alkyl, and —(CH 2 ) n —N(R 7 ) 2 , each of which is optionally substituted by 1, 2, or 3 independently selected R 8 groups; wherein if R 1 and R 2 are both —(C 1 -C 10 )alkyl, at least one of R 1 and R 2 is substituted by at least one R 8 group that is other than —(C 1 -C 10 )alkyl; R 3 and R 4 are each independently selected from (a) —H; or (b—-(C 1 -C 5 )alkyl, —(C 2 -C 5 )alkenyl, and —(C 2 -C 5 )alkynyl; R 5 is selected from (a) —H, halo, —C(halo) 3 , —CH(halo) 2 , and —CH 2 (halo) (b) —(C 1 -C 5 )alkyl, —(C 2 -C 5 )alkenyl, —(C 2 -C 5 )alkynyl, —(CH 2 ) n —O—(CH 2 ) n —CH 3 , —(C 1 -C 5 )alkoxy, each of which is optionally substituted with 1, 2, or 3 independently selected R 8 groups; R 6 is selected from —H, —(C 1 -C 10 )alkyl, —(C 2 -C 10 )alkenyl, —(C 2 -C 10 )alkynyl, and —(C 1 -C 10 )alkoxy; each R 7 is independently selected from —H, —(C 1 -C 10 )alkyl, —(C 2 -C 10 )alkenyl, and —(C 2 -C 10 )alkynyl; each R 8 is independently selected from —OH, halo, —(C 1 -C 10 )alkyl, —(C 2 -C 10 )alkenyl, —(C 2 -C 10 )alkynyl, —(C 1 -C 10 )alkoxy, —(C 3 -C 12 )cycloalkyl, —CHO, —C(O)OH, —C(halo) 3 , —CH(halo) 2 , —CH 2 (halo), and —(CH 2 ) n —O—(CH 2 ) n —CH 3 ; X − is an organic or inorganic anion, selected from the group consisting of sulfate; citrate; acetate; dichloroacetate; trifluoroacetate; oxalate; halide, such as chloride, bromide, iodide; nitrate; bisulfate; phosphate; acid phosphate; isonicotinate; lactate; salicylate; acid citrate; tartrate; oleate; tannate; pantothenate; bitartrate; ascorbate; succinate; maleate; gentisinate; fumarate; gluconate; glucoronate; saccharate; formate; mandelate; formate; arginate; carboxylate; benzoate; glutamate; methanesulfonate; ethanesulfonate; benzenesulfonate; p-toluenesulfonate; and pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate)); each n is independently selected from an integer from 0, 1, 2, 3, 4, 5, or 6 or a pharmaceutically acceptable salt thereof.