Patent ID: 7846677

Claim:
A method of evaluating whether a test compound inhibits replication or virion production of HIV-1 in a human cell, or cell-to-cell spread of HIV-1, the method comprising detecting whether the test compound disrupts the interaction of HIV-1 integrase with a peptide comprising Rpt1 domain of INI1/hSNF5, the Rpt1 domain having the sequence of SEQ ID NO:2, wherein the peptide consists of the sequence of SEQ ID NO:5, or a fragment of SEQ ID NO:5, and wherein the peptide inhibits HIV-1 virion production in a human cell, wherein a compound that disrupts the interaction of HIV-1 integrase with the peptide comprising the Rpt1 domain of INI1/hSNF5 is a candidate for inhibiting replication or virion production of HIV-1 in a human cell, or cell-to-cell spread of HIV-1, and wherein a compound that does not disrupt the interaction of HIV-1 integrase with the peptide comprising the Rpt1 domain of INI1/hSNF5 is not a candidate for inhibiting replication or virion production of HIV-1 in a human cell, or cell-to-cell spread of HIV-1.