Patent ID: 7723380

Claim:
A compound of Formula I or a pharmaceutically acceptable salt, and/or ester thereof, wherein, X is —C(O)—; n is 1; p and q are independently 0 or 1 with the proviso that p and q are not simultaneously zero; L 1 and L 3 are alkylene; L 2 and L 4 are independently selected from the group consisting of a covalent bond, —O—, —NH—, —O-alkylene-, and alkylene; Ar 1 , and Ar 3 are independently aryl, substituted aryl; Ar 2 , and Ar 4 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl; wherein said substituted aryl or said substituted heteroaryl of Ar 1 , Ar 2 , Ar 3 and Ar 4 is independently substituted by one to three substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, nitro, cyano, hydroxy, amino, alkoxy, haloalkoxy, —NH-alkyl, —NH-(alkyl) 2 , —NH-acyl, —N(alkyl)-acyl, —NR a S(O) 2 R b , —C(O)—R c , —S(O) 2 R b , —S(O) 2 NHR a , —C(O)—NH—R a , —NR a C(O)OR b , —NR a S(O) 2 NR a R b , —C(O)OR a , and —Z 1 -alkylene-R 7 ; R a is H, alkyl, or substituted alkyl; R b is alkyl, aryl, or substituted aryl; R 7 is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, —Z 2 -L 5 -R 7b , or —O—PO 3 R 7c R 7d ; L 5 is —C(O)—, —C(O)O—, —C(O)NR 7e , —S(O 2 )—, —S(O)—, S(O 2 )NR 7e , or —S(O)NR 7e —; Z 1 and Z 2 are independently O or NR 7a ; R 7a , R 7c , R 7d , and R 7e are independently H, alkyl, or substituted alkyl; R 7b is alkyl, substituted alkyl, heterocyclyl, or substituted heterocyclyl; R 1 is —OR 1c ; R 1c is wherein A 3 and A 4 are O; m is 1; R 2 , R 4 , and R 5 are each independently selected from the group consisting of H, alkyl, and substituted alkyl; R 3 is H; and R 6 is R 6d and R 6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; or R 6d and R 6e are taken together to form a 5- or 6-membered non-aromatic tetrahydro heterocyclic ring; Z is —NR 14 — or —O—; R 14 is H, alkyl, or substituted alkyl; R 6f1 is H, alkyl, or substituted alkyl; and R 6f2 is alkyl, haloalkyl, hydroxyalkyl, aryl-CH 2 —, or alkoxy; or R 6f2 is wherein D 1 , D 2 , D 3 , D 4 , and D 5 are independently selected from the group consisting of C, N, O, and S; each R 12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R 12 ) r , r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and is a single or double bond; or R 6 is R 6d and R 6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R 6f1 is H, alkyl, or substituted alkyl; and R 6f3 is alkyl, substituted alkyl; or R 6 is OR 6a , wherein R 6a is selected from the group consisting of alkyl and wherein d is 1, R 11 is hydrogen or alkyl.