Patent ID: 7960420

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof; wherein R 1 is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C20 arylalkyl; R 2 is H or C1-C4 alkyl; R 3 is H or C1-C4 alkyl; each of R 4a and R 4b is independently H, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, or C7-C20 arylalkyl; or R 4a and R 4b may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl; R 6 is H, or C1-C8 alkyl, C6-C14 arylalkyl, optionally fluorinated C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, arylsulfonyl, trialkylsilyl, or alkoxycarbonyl; V is H, halo, or OR 10 , where R 10 is H, C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, arylsulfonyl, —PO 3 H 2 , —SO 3 H, —C(O)CR 8 2 NH 2 , —C(O)-L-COOH, or -L-O—PO 3 H 2 ; each of R 5 and R 7 is independently H, or C1-C8 alkyl, C6-C14 arylalkyl, C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, arylsulfonyl, trialkylsilyl, or alkoxycarbonyl, or —PO 3 H 2 , —SO 3 H, —C(O)CR 8 2 NH 2 , —C(O)-L-COOH, or -L-O—PO 3 H 2 ; each R 8 is independently H or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, C7-C20 arylalkyl; and L is a C1-C4 alkylene or C2-C4 alkenylene linker; provided at least one of R 5 , R 7 and R 10 is —PO 3 H 2 , —SO 3 H, —C(O)CR 8 2 NH 2 , —C(O)-L-COOH, or -L-O—PO 3 H 2 ; A is O or NR, where R is hydrogen or C1-4 alkyl; each of W and Z is independently H, halo, OH or C1-C4 alkoxy; and each of X and Y is independently H, halo, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, or COOR 9 or CONR 9 2 , where each R 9 is independently H or C1-C4 alkyl.