Patent ID: 6969712

Claim:
Benzimidazole derivatives represented by the following formula I or pharmaceutically acceptable salts thereof: in which A 1 and A 2 are methine groups or A 1 is fluorinated methine group and A 2 is methine group; B represents a member selected from the group consisting of halogen, cyano, lower alkylcarbonyl, lower alkylsulfonyl, mono-lower alkylsulfamoyl, di-lower alkylsulfamoyl, optionally fluorine-substituted lower alkyl and optionally fluorine-substituted lower alkyloxy; D is an aliphatic, nitrogen-containing heterocyclic group which is selected from the group consisting of those of a formula D-1, formula D-2 and formula D-3 in which R 1 represents hydrogen atom or lower alkyl, and said lower alkyl may be substituted with a substituent selected from a group consisting of halogen, hydroxyl, amino, lower alkyloxy, lower alkylsulfonylamino, aminocarbonylamino, mono-lower alkylcarbamoyl, acetamido, lower cycloalkyl, aromatic heterocyclic group and aromatic carbocyc lie group; R 2 binds to an optional carbon atom or atoms on the aliphatic, nitrogen-containing heterocyclic ring, and represents carboxyl, lower alkyloxycarbonyl, carbamoyl, mono-lower alkylcarbamoyl, di-lower alkylcarbamoyl or lower alkyl, said lower alkyl being optionally substituted with a substituent selected from a group consisting of halogen, hydroxyl, optionally fluorine-substituted lower alkyloxy, lower alkylcarbonyl, carboxyl, lower alkyl, lower alkyloxycarbonyl, carbamoyl, mono-lower alkylcarbamoyl and di-lower alkylcarbamoyl, or two R 2 's together form an oxo group; m1 stands for 0 or an integer of 1-2, and where m1=2, two R 2 's, which may be same or different, bind to same or different optional carbon atom(s) on the aliphatic nitrogen-containing heterocyclic ring; E stands for a single bond, NR or O, R standing for hydrogen atom, methyl or ethyl; stands for a 5-10 membered mono- or di-cyclic aliphatic, nitrogen-containing heterocyclic group which has two nitrogen atoms; stands for a 3-10 membered mono- or di-cyclic aliphatic, nitrogen-containing heterocyclic group which has one nitrogen atom; stands for a 3-10 membered mono- or di-cyclic aliphatic, nitrogen-containing heterocyclic group which has one nitrogen atom; G is a C3-C 20 aliphatic group represented by a formula G-1 in which R 3a and R 3b are same or different and stand for hydrogen atom, methyl or ethyl, R 4 stands for hydrogen atom or optionally substituted lower alkyl, and R 5 and R 6 are same or different and have the same meaning as R 4 , or R 5 and R 6 together form an aliphatic cyclic group, in combination with the carbon atom to which they bind, and n is 0 or an integer of 1-4.