Patent ID: 8728750

Claim:
A process for the preparation of an optically active chiral amine comprising: a) providing an amino acceptor and a racemic mixture of 3-aminopyrrolidine (3AP) protected with a protective group at the ring nitrogen atom (1-N); b) reacting the amino acceptor and the racemic mixture of 3AP protected with a protective group at the 1-N with an isolated (S)-selective transaminase which transfers the primary amino group at position 3 of AP to the amino acceptor, wherein the isolated (S)-selective transaminase being from Vibrio fluviales, Alcaligenes denitrificans, Klebsiella pneumoniae or Bacillus thuringiensis , thereby forming a reaction mixture; and c) producing an optically active chiral (R)-3AP, an amino product and a ketone product in the reaction mixture, wherein the protective group is benzyl, tert-butoxycarbonyl (Boc) or carbobenzoxy (Cbz).