Patent ID: 6953678

Claim:
A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid of formula R—COOH, wherein R is a hydrocarbon residue optionally containing one or more heteroatoms and optionally mono- or polysubstituted, comprising an esterification reaction of said carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, and an orthoester of formula R 1 —C(OR 2 ) 3 , in which R 1 is selected from H and C 1 –C 4 alkyl and R 2 is C 1 –C 8 alkyl or —CH 2 —C 6-10 aryl, for the resolution of said enantiomeric mixture of said chiral carboxylic acid.