Patent ID: 7129258

Claim:
A compound of formula I, wherein R 1 is alkenyl of 2–7 carbon atoms; wherein the alkenyl moiety is optionally substituted with hydroxyl, —CN, halogen, trifluroalkyl, trifluoroalkoxy, —COR 5 , —CO 2 R 5 , —NO 2 , CONR 5 R 6 , NR 5 R 6 or N(R 5 )COR 6 ; R 2 and R 2a are each, independently, hydrogen, hydroxyl, halogen, alkyl of 1–6 carbon atoms, alkoxy of 1–4 carbon atoms, alkenyl of 2–7 carbon atoms, alkynyl of 2–7 carbon atoms, trifluoroalkyl of 1–6 carbon atoms, or trifluoroalkoxy of 1–6 carbon atoms; wherein the alkyl, alkenyl, or alkynyl moieties are optionally substituted with hydroxyl, —CN, halogen, trifluroalkyl, trifluoroalkoxy, —COR 5 , —CO 2 R 5 , —NO 2 , CONR 5 R 6 , NR 5 R 6 or N(R 5 )COR 6 ; R 3 , and R 3a are each, independently, hydrogen, alkyl of 1–6 carbon atoms, alkenyl of 2–7 carbon atoms, alkynyl of 2–7 carbon atoms, halogen, alkoxy of 1–4 carbon atoms, trifluoroalkyl of 1–6 carbon atoms, or trifluoroalkoxy of 1–6 carbon atoms; wherein the alkyl, alkenyl, or alkynyl moieties are optionally substituted with hydroxyl, —CN, halogen, trifluroalkyl, trifluoroalkoxy, —COR 5 , —CO 2 R 5 , —NO 2 , CONR 5 R 6 , NR 5 R 6 or N(R 5 )COR 6 ; R 5 , R 6 are each, independently hydrogen, alkyl of 1–6 carbon atoms, aryl of 6–10 carbon atoms; X is S, or NR 7 ; R 7 is hydrogen, alkyl of 1–6 carbon atoms, aryl of 6–10 carbon atoms, —COR 5 , —CO 2 R 5 or —SO 2 R 5 ; or a pharmaceutically acceptable salt thereof.