Patent ID: 7834036

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ring A is a 5- or 6-membered heteroaromatic ring having 1-2 heteroatoms independently selected from O and N, wherein Ring A together with the phenyl ring to which ring A is fused forms a benzoheteroaromatic ring; Ar 1 and Ar 2 are each carbocyclic or heterocyclic aromatic groups which are independently selected from the group consisting of phenyl and pyridine, said aromatic groups being optionally substituted with 1-4 substituent groups independently selected from halogen, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —OC 1 -C 6 alkyl, —OC 2 -C 6 alkenyl, —C(═O)C 1 -C 6 alkyl , —S(O) n C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, —OC 3 -C 7 cycloalkyl, —NO 2 , and —CN, wherein —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —OC 1 -C 6 alkyl, —OC 2 -C 6 alkenyl, —C(═O)C 1 -C 6 alkyl, —S(O) n C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, and —OC 3 -C 7 cycloalkyl are each optionally substituted with 1-5 halogens; B is selected from the group consisting of —O—, —S(O) n —, —N(R 3 )—, —C(═O)—, and —C(R 4 ) 2 —, —WZ is selected from the group consisting of —O—C(R 5 )(R 6 )—Z, —S(O) n —C(R 5 )(R 6 )—Z, and —CH 2 —C(R 5 )(R 6 )—Z ; Z is selected from the group consisting of —CO 2 R 7 and tetrazole; R 1 and R 2 are each independently selected from the group consisting of halogen, —CN, —NO 2 , —OH, —C 1 -C 5 alkyl, —OC 1 -C 5 alkyl, —C(═O)C 1 -C 5 alkyl, —S(O) n C 1 -C 5 alkyl, and C 3-6 cycloalkyl, wherein C 1 -C 5 alkyl, —OC 1 -C 5 alkyl, —C(═O)C 1 -C 5 alkyl, —S(O) n C 1 -C 5 alkyl, and C 3-6 cycloalkyl are optionally substituted with 1-5 halogens; R 3 is selected from the group consisting of H and C 1 -C 5 alkyl; each R 4 is independently selected from the group consisting of H, halogen, and —C 1 -C 5 alkyl, wherein —C 1 -C 5 alkyl is optionally substituted with 1-5 halogens; R 5 and R 6 are each independently selected from the group consisting of H, halogen, —C 1 -C 5 alkyl, —OC 1 -C 5 alkyl, —C 2 -C 5 alkenyl, —OC 2 -C 5 alkenyl, C 3-6 cycloalkyl, —(CH 2 ) m phenyl, and —O(CH 2 ) m phenyl, wherein —C 1 -C 5 alkyl, —OC 1 -C 5 alkyl, —C 2 -C 5 alkenyl, and —OC 2 -C 5 alkenyl are optionally substituted with 1-5 halogens, and wherein C 3-6 cycloalkyl and the phenyl of —(CH 2 ) m phenyl and —O(CH 2 ) m phenyl are optionally substituted with 1-5 groups independently selected from halogen, C 1 -C 3 alkyl and —OC 1 -C 3 alkyl, said C 1 -C 3 alkyl and —OC 1 -C 3 alkyl being optionally substituted with 1-3 halogens; or alternatively R 5 and R 6 may be joined to form a C 3 -C 6 cycloalkyl group, said C 3 -C 6 cycloalkyl group optionally being substituted with 1-3 halogens; R 7 is selected from the group consisting of H and —C 1 -C 6 alkyl, wherein C 1 -C 6 alkyl is optionally substituted with 1-5 halogens; m in each instance is an integer from 0-2; n in each instance is an integer from 0-2; p is an integer from 0 to 3; and q is an integer from 0-3.