Patent ID: 6982275

Claim:
A method for producing an optically active form of a compound represented by the formula (II): wherein ring A is a benzene ring optionally having 1 to 3 substituent(s) selected from (a) a halogen atom, (b) a cyano, (c) a nitro, (d) an alkyl optionally having 1 to 3 substituent(s) selected from a halogen atom, a hydroxy, a C 1-6 alkoxy, a C 1-6 alkoxy-carbonyl and a carbamoyl, (e) a hydroxy, (f) an alkoxy optionally having 1 to 3 substituent(s) selected from a halogen atom, a hydroxy, a C 1-6 alkoxy, a C 1-6 alkoxy-carbonyl and a carbamoyl, (g) an aryl, (h) an aryloxy, (i) a carboxy, (j) an acyl, (k) an acyloxy and (l) a 5- to 10-membered heterocyclic group, R 1 is a hydrogen atom; a hydrocarbon group selected from (A) an alkyl group, an alkenyl group and an alkynyl group, each of which optionally has 1 to 3 substituent(s) selected from (a) an alkylthio group, (b) a halogen, (c) an alkoxy group, (d) an acyloxy group, (e) a nitro group, (f) an alkoxy-carbonyl group, (g) an alkylamino group, (h) an alkoxyimino group and (i) a hydroxyimino, and (B) an aryl group and an aralkyl group, each of which optionally has 1 to 5 substituent(s) selected from (a) an alkyl group, (b) an alkenyl group, (c) an alkynyl group, (d) an alkoxy group, (e) an acyl group, (f) a nitro, (g) an amino, (h) a hydroxy, (i) a cyano, (j) a sulfamoyl, (k) a mercapto, (l) a halogen and (m) an alkylthio group; an acyl group or an acyloxy group, R 2 , R 3 and R 4 are each a hydrogen atom; an alkyl group optionally having 1 to 3 substituent(s) selected from a halogen atom, a hydroxy, a C 1-6 alkoxy, a C 1-6 alkoxy-carbonyl and a carbamoyl; an alkoxy group optionally having 1 to 3 substituent(s) selected from a halogen atom, a hydroxy, a C 1-6 alkoxy, a C 1-6 alkoxy-carbonyl and a carbamoyl; an amino; a mono-C 1-6 alkylamino; a mono-C 6-14 arylamino; a di-C 1-6 alkylamino or a di-C 6-14 arylamino, X is a nitrogen atom or CH, Y is a nitrogen atom or CH, and * is an asymmetric center, or a salt thereof, comprising reacting a compound represented by the formula (I): wherein each symbol is as defined above, or a salt thereof, with an excess amount of an oxidizing agent in the presence of a catalyst for asymmetric induction and a base; wherein the amount of the oxidizing agent to be used is about 1.5 to about 10 molar equivalents relative to the compound represented by the formula (I) or a salt thereof.