Patent ID: 7786116

Claim:
A compound of formula (I) wherein a is an integer from 0 to 4; R 1 is selected from the group consisting of halogen, C 1-4 alkyl, C 1-4 alkoxy, halogenated C 1-4 alkyl and halogenated C 1-4 alkoxy; is selected from the group consisting of aryl and heteroaryl; R 2 is selected from the group consisting of hydrogen and C 1-4 alkoxy; R 3 is selected from the group consisting of hydrogen, C 1-8 alkyl, hydroxy substituted C 2-8 alkyl, NR A R B substituted C 2-8 alkyl, —C 1-4 alkyl-O—C 1-4 alkyl, cycloalkyl, —(C 1-4 alkyl)-cycloalkyl, heterocycloalkyl and —(C 1-4 alkyl)-heterocycloalkyl; wherein R A and R B are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; A 1 is selected from the group consisting of —(CH 2 ) b —; wherein b is an integer from 2 to 4; L 1 is selected from the group consisting of —NR C — and —C(O)—NR C —; wherein R C is selected from the group consisting of hydrogen, C 1-8 alkyl, hydroxy substituted C 1-4 alkyl, —C 1-4 alkyl-O—C 1-4 alkyl and C 5-7 cycloalkyl; R 4 is selected from the group consisting of C 1-8 alkyl, C 2-12 alkenyl, —C 1-4 alkyl-O—C 1-4 alkyl, —C 1-4 alkyl-NR D R E , —C 1-4 alkyl-OH, cycloalkyl, —C 1-4 alkyl-cycloalkyl, partially unsaturated carbocyclyl, —C 1-4 alkyl-(partially unsaturated carbocyclyl), aryl, aralkyl, heteroaryl, —C 1-4 alkyl-heteroaryl, heterocycloalkyl and —C 1-4 alkyl-heterocycloalkyl; wherein R D and R E are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; and wherein the cycloalkyl, partially unsaturated carbocyclyl, aryl, heteroaryl or heterocycloalkyl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of fluoro, C 1-4 alkyl, —C 1-4 alkyl-O—C 1-4 alkyl, carboxy, —C(O)O—C 1-4 alkyl and aralkyl; alternatively, L 1 is —NR C — and R C and R 4 are taken together with the nitrogen atom to which they are attached to form a ring structure selected from the group consisting of 1-pyrazolyl, 1-imidazolyl and 1-(1,2,3-triazolyl); wherein the 1-pyrazolyl, 1-imidazolyl or 1-(1,2,3-triazolyl) is optionally substituted with a substituent selected from the group consisting of C 1-6 alkyl; or a pharmaceutically acceptable salt thereof.