Patent ID: 8598359

Claim:
A compound of formula: wherein Ar is selected from the group consisting of phenyl optionally substituted with from one to three substituents independently selected from the group consisting of halogen, loweralkyl, loweralkoxy, fluoroloweralkyl, fluoroloweralkoxy, hydroxy, hydroxy(C 1 -C 4 ) alkyl, formyl, formyl(C 1 -C 4 ) alkyl, cyano, cyano(C 1 -C 4 ) alkyl, benzyl, benzyloxy, phenyl, heteroaryl, heterocyclylalkyl, and substituted heteroaryl; and heteroaryl selected from benzoxazole, benzothiazole, benzimidazole, pyridine, pyrazole, thiophene, furan, and thiazole, wherein said heteroaryl is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, loweralkyl, loweracyl, loweralkoxy, fluoroloweralkyl, fluoroloweralkoxy, formyl, cyano, benzyl, benzyloxy, phenyl, heteroaryl, and heterocyclylalkyl; X is selected from the group consisting of direct bond, O, NR 1 , CH 2 , CF 2 , CH 2 CH 2 , CH 2 NR 1 , NR 1 CH 2 , CH═CH, C═O, CH 2 C═O, CR 1a R 1b , OCR 1a R 1b , and CR 1a R 1b O; Ar is attached to X via a ring atom of Ar; R 1 is selected separately in each occurrence from the group consisting of H and lower alkyl; R a is selected from the group consisting of H, OH and lower alkyl; R 1b is selected from the group consisting of H and lower alkyl; Q is —O—; n is an integer selected from 1-5; HET is selected from the group consisting of piperidine and piperazine, wherein said piperidine or piperazine is optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, carboxy, loweralkyl, benzyl, and benzyloxy; and taken together ZW is H or Z is (CH 2 ) 1-10 , in which one (CH 2 ) may optionally be replaced by NR 1 provided that said NR 1 is not at the point of attachment to HET; W is selected from the group consisting of acyl, hydroxyl, carboxyl, C(O)NHR 4 , COOalkyl, heterocyclyl, heterocyclyl substituted with (C 1 -C 4 ) alkyl, and C(O)NH(OH); and R 4 is selected from the group consisting of H, (C 1 -C 4 ) alkyl, and phenyl(C 1 -C 4 ) alkyl, with the proviso that when Q is —O—, HET is piperidine, and Ar is phenyl or halo-substituted phenyl, then the Z-W combination is other than H.