Patent ID: 8772494

Claim:
A compound of formula (I) the N-oxides, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R 1 is hydrogen, C 1-4 alkyl, halo, or polyhaloC 1-4 alkyl; R 2 is hydrogen, C 1-4 alkyl, halo, or polyhaloC 1-4 alkyl; R 3 is hydrogen or C 1-4 alkyl; R 4 is hydrogen, C 1-4 alkyl, or halo; n is an integer 0, or 1; X 1 is carbon and X 2 is carbon; or X 1 is nitrogen and X 2 is carbon; or X 1 is carbon and X 2 is nitrogen; X 3 is carbon or nitrogen; Y represents O, or NR 6 wherein R 6 is hydrogen or C 1-4 alkyl; R 5 represents a radical of formula wherein m is an integer 0, 1, or 2; Z is O or NH; R 7 is hydrogen, C 1-6 alkyl; C 1-6 alkyl substituted with hydroxy, amino, mono- or di(C 1-4 alkyl)amino, C 1-4 alkyloxycarbonyl, aminocarbonyl, aryl or heteroaryl; C 1-4 alkyl-O—C 1-4 alkyl; C 1-4 alkyl-S—C 1-4 alkyl; or aryl; R 8 is hydrogen or C 1-6 alkyl; R 9 is C 1-4 alkyl; or when Y represents NR 6 the radicals R 5 and R 6 may be taken together with the nitrogen to which they are attached to form pyrrolidinyl substituted with C 1-4 alkyloxycarbonyl and optionally further substituted with hydroxy; or piperidinyl substituted with C 1-4 alkyloxycarbonyl; aryl is phenyl; phenyl substituted with one, two or three substituents each independently selected from C 1-4 alkyl, C 1-4 alkyloxy, halo, hydroxy, nitro, cyano, C 1-4 alkyloxycarbonyl, trifluoromethyl, or trifluoromethoxy; or benzo[1,3]dioxolyl; and heteroaryl is imidazolyl, thiazolyl, indolyl, or pyridinyl.