Patent ID: 7112601

Claim:
A compound of Formula (I) A is CO 2 ; R 5 , CONSO 2 R 5 , or SO 2 NCOR 5 , Het is pyrazole, X is O; R 1 in hydrogen, halogen, C 1-6 alkyl, trifluoromethyl, or phenyl; R 2 is a saturated C 3-7 cycloalkyl or a saturated C 5-12 bridged bicycloalkyl; R 3 is hydrogen, halogen, C 1-6 alkyl, or C 1-6 alkoxy; R 5 is hydrogen or C 1-6 alkyl; R 6 is hydrogen, methyl, or OR 5 ; R 7 is C 1-6 alkoxy, cyano, trifluoromethyl, —CO 2 R 5 , —CONR 9 R 10 , SO 2 R 5 , or SO 2 NR 9 R 10 ; R 8 is hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, cyano, trifluoromethyl, aceto, CO 2 R 5 , or CONR 9 R 10 ; R 9 and R 10 are independently hydrogen, C 1-6 alkyl, —CH 2 CH 2 OH; or NR 9 R 10 taken together form pyrrolidine, piperidine, 4-hydroxypipendine, piperazine, 4-methylpiperazine, morpholine, or thiomorpholine; and Ar 1 is thiophene or phenyl substituted with 0–3 substituents selected from halogen, C 1-6 alkyl, C 1-6 alkoxy, cyano, trifhoromethyl, aceto, CO 2 R 5 , and CONR 9 R 10 ; or a pharmaceutically acceptable salt or solvate of these compounds.