Patent ID: 8905913

Claim:
A method of synchronizing time of insemination in a swine without heat detection, the method comprising the step of, administering to the swine, on the fourth day after weaning, a dose of a hormone of the formula or a solvate, a hydrate, or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are independently in each instance hydrogen, or are independently selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, haloalkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl, each of which is optionally substituted, or R 1 and R 2 and the attached carbon form a carbocycle or heterocycle; X is hydrogen, or X is selected from the group consisting of, alkyl, cycloalkyl, heteroalkyl, optionally substituted alkylene-carboxamide; and HNC(O)NR 3 R 4 , where R 3 and R 4 are in each instance independently selected from the group consisting of hydrogen, alkyl, heteroalkyl and haloalkyl, wherein the swine is inseminated only one time about 15 to about 24 hours after administration of the hormone and wherein there is no heat detection.