Patent ID: 7345202

Claim:
A method for resolving an enantiomeric mixture of enantiomers B, wherein enantiomers B are basic enantiomers mixture of amines of formula (II), (R1,R2)N—H (II) comprising the steps of: a) reacting in a liquid medium said enantiomeric mixture of basic enantiomers with a chiral sulfamic acid having an enantiomeric purity of at least 90% of formula (I): (R1,R2)N—SO3H (I) wherein: R1 and R2, being the same or different, are selected from the group consisting of: hydrogen, a linear, branched or cyclic alkyl or heteroalkyl group, being optionally substituted, or an aromatic, being optionally substituted, provided that R1 and R2 are not both hydrogen and that at least one of the R1 and R2 groups is chiral, to obtain diastereomeric salts of formula (IV): wherein B is enantiomers mixture of amines of formula (II), resulting in preferential crystallization of either the p- or the n-diastereomeric salt, b) recovering the crystallized salt obtained in step a), c) treating the recovered crystallized salt of b) with a base to obtain the enantiomers B in an enantiomerically enriched form, and, optionally, d) recovering the sulfamic acid from c).