Patent ID: 7994198

Claim:
A compound of formula (I) in free or pharmaceutically acceptable salt form: wherein R is —C 1-3 alkylAr 1 where Ar 1 is phenyl; wherein phenyl is substituted by one or more substituents selected from CN, CON(R 1 ) 2 , SO n R 2 , SO 2 N(R 1 ) 2 , N(R 5 ) 2 , N(R 1 )COR 2 , N(R 1 )SO n R 2 , C 0-6 alkylAr 2 , C 2-6 alkenylAr 2 and C 3-6 alkynylAr 2 wherein one or more of the —CH 2 — groups of the alkyl chain may be replaced with a heteroatom selected from O, S and NR 3 , provided that when the heteroatom is O, at least two —CH 2 — groups separate it from any additional O atom in the alkyl chain; or two adjacent substituents on the Ar 1 phenyl may together form a fused 5- or 6-membered saturated or unsaturated ring wherein the ring optionally contains 1 or 2 heteroatoms selected from O, S and NR 4 and is optionally substituted by one or more substituents selected from, an oxo group, C 1-6 alkyl and C 0-3 alkylAr 4 ; and the Ar 1 phenyl is optionally substituted by one or more additional substituents selected from F, Cl, Br, CF 3 , OCF 3 , OR 3 and C 1-6 alkyl; R 1 is H, C 1-6 alkyl optionally substituted by OH, Ar 3 , or C 1-6 alkylAr 3 , or the group N(R 1 ) 2 may form a 5- to 10-membered heterocyclic group optionally containing one or more additional heteroatoms selected from O, S and NR 3 and is optionally substituted by an oxo group; R 2 is C 1-6 alkyl optionally substituted by OH, Ar 3 , or C 1-6 alkylAr 3 ; R 3 is H, or C 1-6 alkyl; R 4 is H, C 1-6 alkyl or C 0-3 alkylAr 4 ; R 5 is H, C 1-6 alkyl optionally substituted by OH, Ar 3 , or C 1-6 alkylAr 3 , or the group N(R 5 ) 2 may form a 5- to 10-membered heterocylic group optionally containing one or more additional heteroatoms selected from O, S and NR 3 and is optionally substituted by an oxo group; Ar 2 and Ar 3 are independently phenyl or a 5- to 10-membered heteroaryl group containing up to 3 heteroatoms selected from O, S and NR 3 , which may be optionally substituted by one or more substituents selected from F, Cl, Br, CN, CF 3 , OCF 3 , OR 3 and C 1-6 alkyl; Ar 4 is phenyl or pyridyl either of which may be optionally substituted by one or more substituents selected from F, Cl, Br, CN, CF 3 , OCF 3 , OR 3 and C 1-6 alkyl; and n=0, 1 or 2.