Patent ID: 8277782

Claim:
A topical oral care composition for controlling oral cavity bacterial infection and reducing risk of developing an oral bacteria-induced systemic disease in human and other animal subjects, said composition consisting essentially of: a) a safe and effective amount of a combination of anti-oxidant and H2-antagonist host-response modulating agents, wherein the anti-oxidant is selected from one or a mixture of gallic acid, N-acetyl cysteine, or anethole dithiolthione and the H2-antagonist is selected from one or a mixture of cimetidine, etintidine, ranitidine, tiotidine, lupitidine, donetidine, famotidine, roxatidine, pifatidine, lamtidine, zaltidine, nizatidine, mifentidine, ramixotidine, loxtidine, bisfentidine, sufotidine, ebrotidine, or impromidine, b) a safe and effective amount of an additional oral therapeutic active selected from one or a mixture of antimicrobial/antiplaque agents selected from benzalkonium chloride, salicylanilide, domiphen bromide, cetylpyridinium chloride, tetradecylpyridinium chloride, and N-tetradecyl-4-ethylpyridinium chloride, and c) a pharmaceutically acceptable oral carrier.