Patent ID: 7033834

Claim:
A method for delivering genetic material to a target cell in vitro , comprising: preparing a gene delivery vehicle comprising an expressible nucleic acid molecule encoding a gene of interest, a virus including a capsid or envelope surrounding said expressible nucleic acid molecule, and a first member of a specific binding pair, said first member of the specific binding pair expressed by recombinant expression on an exterior of said capsid or envelope; coupling a bispecific conjugate to said first member of the specific binding pair to form a gene delivery vehicle complex, said bispecific conjugate comprising a second member of the specific binding pair covalently coupled to a targeting moiety, said targeting moiety capable of binding to a target molecule associated with a surface of the target cell; and delivering said gene delivery vehicle complex to the target cell in vitro , wherein said first member of the specific binding pair comprises an immunoglobulin binding moiety having binding specificity to a constant region of an immunoglobulin.