Patent ID: 8598209

Claim:
A compound of structural formula I: or pharmaceutically acceptable salts and individual enantiomers and diastereomers thereof wherein: A represents pyridinyl, or pyridinonyl; W and Z independently are absent or represent C(R 2 ) 2 , —O—, NR 2 , CO, or SO 0-2 ; R 2 represents H, C 1-6 alkyl, CF 3 , OH, CHF 2 , or CH 2 F; R 3 represents CR 2 R 4 R 5 , (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocycle, said cycloalkyl, and heterocyclyl optionally substituted with 1 to 3 groups of R a ; or R 2 and R 3 can be combined with the nitrogen to which they are attached to form a C 5-10 heterocyclyl optionally substituted with 1 to 3 groups of R a ; R 4 and R 5 independently represent H, (CH 2 ) n OR 2 , CHF 2 , (CH 2 ) n CF 3 , (CH 2 ) n C 5-10 heterocyclyl, (CH 2 ) n C 6-10 aryl, C 3-10 cycloalkyl, C 1-6 alkoxy, C 2-6 alkenyl, C(O) 1-2 R 2 , or C 1-6 alkyl; said alkyl, cycloalkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of R a ; R 6 represents hydrogen, OR 2 , —O—,CF 3 , C(R 2 ) 2 OR 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocyclyl, said alkyl, aryl and heterocyclyl optionally substituted with 1 to 3 groups of R a ; R 7 represents C 1-6 alkyl, C 3-10 cycloalkyl, (CH 2 ) n C 5-10 heterocyclyl, or (CH 2 ) n C 6-10 aryl, said alkyl, cycloalkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of R a ; R a represents C 1-6 alkyl, halogen, hydroxyl, OR 2 (CH 2 ) n CF 3 , —O—, C 3-6 cycloalkyl, NR 2 C(O)R 2 , C(O)N(R 2 ) 2 , C(R 2 ) 2 OR 2 , C(O)R 2 , NO 2 , CN, N(R 2 ) 2 , C(O)OR 2 , SO 2 R 2 , OR 2 , (CH 2 ) n C 5-10 heterocyclyl, or (CH 2 ) n C 6-10 aryl, said heterocyclyl and aryl optionally substituted with 1 to 3 groups of C 1-6 alkyl, halogen, hydroxyl, (CH 2 ) n CF 3 , or CN; and n represents 0 to 4, provided that when A is pyridinonyl WZR 6 is not hydrogen or when A is pyridinyl, W is CO, Z is NR 2 (where R 2 in NR 2 is alkyl), R 2 is hydrogen or alkyl, and R 3 is alkyl, then R 6 is not hydrogen or alkyl.