Patent ID: 8208189

Claim:
An apparatus comprising: a handpiece movable over skin, the handpiece arranged to receive an optical beam having an absorption coefficient in water of about 100 cm −1 to 12,300 cm −1 , the handpiece configured to focus the optical beam at a plurality of spaced-apart locations on the skin with a pulse energy per location of 5 mJ to 40 mJ thereby creating a plurality of voids in the skin for the deposition of a composition, wherein the composition comprises a stem cell and a growth media, and the handpiece is configured to focus the optical beam to create voids with a depth of about 200 μm to 4 mm, with a density of 200 to 4000 voids per cm 2 per pass, at a rate of 100 per second to 5000 per second, and such that viable tissue separating adjacent voids has a width, at a narrowest point thereof, between about 50 μm and 500 μm.