Patent ID: 8476302

Claim:
A compound of formula (I) wherein R 1 is an aromatic ring selected from the group consisting of phenyl, pyridyl, pyrimidinyl, thiazolyl, and quinolinyl; wherein the aromatic ring is optionally substituted with one to two substituents independently selected from the group consisting of halogen, C 1-4 alkyl, trifluoromethyl, C 1-4 alkoxy, trifluoromethoxy, cyano, —C(O)—NR A R B , —NH—C(O)—(C 1-4 alkyl), and phenyl; and wherein R A and R B are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; L 1 is selected from the group consisting of -(n-pentyl)-, -(n-hexyl)-, —O—(n-pentyl)-, —NH-(n-pentyl)-,—CH═CH-(n-propyl)-, —CH═CH-(n-butyl)-, —CC-(n-propyl)- and —CC-(n-butyl)-; X is selected from the group consisting of —NH—, —O— and —S—; is selected from the group consisting of (a) a is an integer from 0 to 2; each R 4 is independently selected from the group consisting of halogen, C 1-4 alkyl, trifluoromethoxy, NR 6 R 7 , —C(O)—NH—CH 2 CH 2 —NR 6 R 7 and phenyl; wherein R 6 and R 7 are each independently selected form the group consisting of hydrogen and C 1-4 alkyl; wherein the R 4 phenyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, C 1-4 alkyl, trifluoromethyl, C 1-4 alkoxy and trifluoromethoxy; (b) L 2 is selected from the group consisting of —O—, —NR 7 — and —S(O)—; wherein R 7 is selected from the group consisting of hydrogen, C 1-4 alkyl and t-butoxycarbonyl; R 5 is an aromatic ring structure selected from the group consisting of phenyl, benzyl, phenylethyl-, imidazolyl, imidazolyl-methyl-, pyridyl, pyridyl-methyl-, pyrimidinyl, pyrimidinyl-methyl-, furyl, furylmethyl-, quinolinyl, quinolinyl-methyl-, benzo[d][1,2,3]triazolyl and benzo[d][1,2,3]triazolyl-methyl-; wherein the R 5 aromatic ring structure is optionally substituted with one to two substituents independently selected from the group consisting of halogen, C 1-4 alkyl, trifluoromethyl, C 1-4 alkoxy, trifluoromethoxy, —C(O)OH, —C(O)—O—C 1-4 alkyl, cyano, and —C(O)—NR 8 R 9 ; wherein R 8 and R 9 are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; alternatively R 5 is 4-(pyrid-4-yl-N-oxide-methoxy)-phenyl; and wherein the -L 2 -R 5 group is bound at the 3- or 4-position; (c) naphth-2-yl; and (d) a heteroaryl selected from the group consisting of pyridyl, benzo[d][1,3]dioxolyl, dibenzo[b,e][1,4]dioxinyl, and 2,3-dihydropyrrolo[2,1-b]quinazolin-9-one; or a pharmaceutically acceptable salt thereof.