Patent ID: 7087750

Claim:
A compound of formula (I): wherein Ar is (1) a 5- to 10-membered monocyclic or bicyclic heterocyclic ring having 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur, or nitrogen, or (2) —R 9 -phenyl; wherein the phenyl, or heterocyclic ring is optionally substituted with halogen, C 1-6 alkyl, CF 3 , hydroxyl, C 1-6 alkoxyl, OCF 3 , COCF 3 , CN, NO 2 , phenyloxy, phenyl, C 1-6 alkylsulfonyl, C 2-6 alkenyl, —NR 7 R 8 , C 1-6 alkylcarboxyl, formyl, —C 1-6 alkyl-NH—CO-phenyl, —C 1-6 alkyl-CO—NH-phenyl, —NH—CO—C 1-6 alkyl, —CO—NR 7 R 8 , or SR 7 ; wherein each of R 7 and R 8 is independently H or C 1-6 alkyl; and R 9 is C 1-6 alkyl or C 2-6 alkenyl, either of which is optionally substituted with phenyl or phenyloxy; R 2 is H, phenyl, I, or C 1-6 alkyl; R 3 is H or 3-(1-azabicyclo[2.2.2]oct-2-en)yl; R 4 is H or is selected from the group consisting of: wherein R 6 is H, C 1-6 alkyl, or benzyl; and R 5 is H, hydroxy, C 1-3 alkoxy, F, NO 2 , CF 3 , OCF 3 , or is selected from the group consisting of: or a pharmaceutically acceptable salt, hydrate, or stereoisomer thereof, with the proviso that when R 2 is alkyl, R 4 is not H.