Patent ID: 8580281

Claim:
A medicated patch comprising a support and a pressure-sensitive adhesive, wherein the pressure-sensitive adhesive comprises a composition containing as a medicinal agent varenicline in its free base form, a metal salt, an adhesive base material and an adsorbent that adsorbs a polar solvent in the composition, wherein varenicline in its free base form and the metal salt are produced by a neutralization reaction between a medicinal agent acid addition salt and a metal hydroxide, which is added in an amount to convert all or a portion of the medicinal agent to the free base form, wherein the medicinal agent acid addition salt is selected from hydrochloride, acetic acid salt, sulfuric acid salt, maleic acid salt, oxalic acid salt, citric acid salt, hydroiodic acid salt, hydrobromic acid salt, mesylic acid salt, tartaric acid salt or succinic acid salt of the medicinal agent, wherein the composition has a pH of 7.5 or greater, and wherein the adhesive base material is an acrylic-based polymer containing no carboxyl groups and no vinyl acetate as a monomer unit.