Patent ID: 8153639

Claim:
A compound which is a fused pyrimidine of formula (I): wherein X is S; n is 0, 1 or 2; R 1 is a group of formula: wherein p is 0 or 1; R 30 is H or C 1 -C 6 alkyl; R 4 and R 5 form, together with the N atom to which they are attached, a 5- or 6-membered saturated N-containing heterocyclic group which includes 0 or 1 additional heteroatoms selected from N, S and O, which may be fused to a benzene ring and which is unsubstituted or substituted; or one of R 4 and R 5 is alkyl and the other is a 5- or 6-membered saturated N-containing heterocyclic group as defined above or an alkyl group which is substituted by a 5- or 6-membered saturated N-containing heterocyclic group as defined above; R 2 is a heteroaryl group which contains 1, 2, 3 or 4 ring nitrogen atoms and 0, 1 or 2 additional heteroatoms selected from O, N and S, which group is monocyclic or bicyclic and which is unsubstituted or substituted; and R 3 is selected from: (a) a group of the following formula: wherein B is a phenyl ring which is unsubstituted or substituted and Z is selected from H, —OR, —SR, CH 2 OR, —CO 2 R, CF 2 OH, CH(CF 3 )OH, C(CF 3 ) 2 OH, —(CH 2 ) q OR, —(CH 2 ) q NR 2 —C(O)N(R) 2 , —NR 2 , —NRC(O)R, —S(O) m N(R) 2 , —OC(O)R, OC(O)N(R) 2 , —NRS(O) m R, —RC(O)N(R) 2 , CN and —NO 2 , wherein each R is independently selected from H, C 1 -C 6 alkyl, C 3 - C 10 cycloalkyl and a 5-to 12-membered aryl or heteroaryl group, the group being unsubstituted or substituted, m is 1 or 2 and q is 0, 1 or 2; (b) a heteroaryl group which contains 1, 2, 3 or 4 ring nitrogen atoms and 0, 1 or 2 additional heteroatoms selected from O and S, which group is monocyclic or bicyclic and which is unsubstituted or substituted; and (c) a group comprising a benzene ring which is unsubstituted or substituted and which is fused to a heteroaryl group as defined above; or a pharmaceutically acceptable salt thereof.