Patent ID: 7625939

Claim:
A compound of formula (I): wherein R 1 and R 2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, heterocyclyl, carbocyclyl, aryl, -alkylaryl, heteroaryl-alkylheteroaryl and an amino acid or a peptide residue; R 3 represents hydrogen; Z is a group of formula I or II: wherein X 1 and X 2 independently represent OR 4 ; R 4 is selected from the group consisting of hydrogen; alkyl, alkenyl, alkynyl, cycloalkyl any of which aforementioned four groups may optionally be substituted by hydroxy; heterocyclyl, carbocyclyl, aryl, -alkylaryl, heteroaryl and -alkylheteroaryl; Y 1 and Y 2 are independently selected from hydroxy, alkoxy, cycloalkyloxy, aryloxy and heteroaryloxy; or Y 1 and Y 2 are connected to form one of the following cyclic boronic diester groups: wherein R 9 -R 18 are independently hydrogen, alkyl, cycloalkyl or aryl; and each R 19 group is independently selected from hydrogen, alkyl, aryl, halo, alkoxy, aryloxy, thioalkyl and thioaryl; when Z represents a group of formula (I): then R 3 may also represent alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, heterocyclyl, carbocyclyl, aryl, -alkylaryl, -alkylheteroaryl, an amino acid or a peptide residue; and when Z represents a group of formula (I) R 1 and R 3 may also optionally be connected to form a ring of the structure of formula (III) wherein m is an integer in the range of 2 to 6; R 2 is as defined above; and R 5 and R 6 are independently selected from hydrogen, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, cycloalkyl, halo, amino, substituted amino, carbocyclyl, aryl, arylalkyl-, heteroaryl, heteroarylalkyl-, heterocyclyl, alkylcarbonylamino-, arylcarbonylamino-, alkoxycarbonylamino-, aryloxycarbonylamino-, alkoxycarbonyl-, aryloxycarbonyl-, and alkylaminocarbonylamino-; including all stereoisomers and pharmaceutically acceptable salts thereof.