Patent ID: 7291640

Claim:
A compound of formula (I) wherein V and X are each CR 6 ; W and Y are each N; Z is C—H or N; R 1 is (i) a phenyl ring substituted with two or more substituents, which may be the same or different, each independently selected from halo, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, cyano, C(O)NR 7 R 8 , NR 7 R 8 , NR 7 C(O)R 10 and N[C(O)R 10 ] 2 ; R 2 is selected from: (i) H, OH, OR 9 , NR 7 R 8 , NR 7 C(O)R 10 and N[C(O)R 10 ] 2 ; (ii) a 5-7 membered N-linked heterocycle containing 1-3 heteroatoms selected from N, O and S; said ring being optionally substituted with one or more groups selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy and C(O)NR 7 R 8 ; and (iii) (C 1 -C 6 )alkyl optionally substituted with an N-linked 5-7 membered heterocycle containing 1-3 heteroatoms selected from N, O and S; R 3 is selected from H and (C 1 -C 6 )alkyl; R 4 is selected from H, (C 1 -C 6 )alkyl and OR 9 ; R 5 is selected from halo, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, NR 7 R 8 , NR 7 C(O)R 10 and N[C(O)R 10 ] 2 ; R 6 is selected from H, halo, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, cyano, NR 7 R 8 , NR 7 C(O)R 10 , N[C(O)R 10 ] 2 and C(O)NR 7 R 8 ; R 7 and R 8 , which may be the same or different, are selected from H and (C 1 -C 6 )alkyl; R 9 is (C 1 -C 6 )alkyl, which is optionally substituted with with one or more groups each independently selected from (C 1 -C 6 )alkoxy and an N-linked 5-7 membered heterocycle containing 1-3 heteroatoms selected from N, O and S; and R 10 is selected from (C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; or a tautomer thereof or a pharmaceutically acceptable salt or solvate of said compound or tautomer.