Patent ID: 8278344

Claim:
A method of treating necrosis or necroptosis in a subject having a condition selected from stroke, myocardial infarction, organ ischemia, traumatic brain injury, liver disease, cancer chemo/radiation therapy-induced necrosis, acute necrotizing pancreatitis, or a neurodegenerative disease, said method comprising the step of administering a compound according to the following formula, wherein R 1 is a lower alkyl group; R 2 is selected from hydrogen and an electron withdrawing group; R 3 is selected from hydrogen and an (S)-lower alkyl group; each of R 4 , R 5 , and R 6 is independently selected from hydrogen, lower alkyl, halogen, amino, amido, alkoxy, and cyano; and each X 1 and X 2 is, independently, halogen; or any pharmaceutically acceptable salt thereof, or stereoisomer thereof.