Patent ID: 7288258

Claim:
A polyepitope of E7 protein from HPV, consisting of 23 amino acids delimited by the amino acids located in positions 3 and 25 of the peptide sequence of the E7 protein of HPV, wherein said polyepitope comprises peptide sequence SEQ ID NO: 14 as follows: (3)GDTPTLHEYMLDLQPETTDLYCY(25) and wherein said peptide sequence comprises 5 epitopes binding stably to at least one of 6 HLA molecules of the following types: A1, A2, B18, B35, B44 or B62, said epitopes being selected from the group consisting of: (3)GDTPTLHEY(11) (residues 3 to 11 of SEQ ID NO: 12) binding stably to HLA molecules of the B44 type, (5)TPTLHEYML(13) (residues 5 to 13 of SEQ ID NO: 12) binding stably to HLA molecules of the B35 type, (11)YMLDLQPETT(20) (residues 11 to 20 of SEQ ID NO: 12) binding stably to HLA molecules of the A2 type, (15)LQPETTDL Y(23) (residues 15 to 23 of SEQ ID NO: 12) binding stably to HLA molecules of the B62 type, and (16)QPETTDLYCY(25) (residues 16 to 25 of SEQ ID NO: 12) binding stably to HLA molecules of the Al or B18 type.