Patent ID: 7416848

Claim:
A process for determining whether a chemical compound specifically binds to and activates a mammalian SNORF25 receptor, which comprises contacting cells producing a second messenger response and expressing on their cell surface the mammalian SNORF25 receptor, wherein such cells do not normally express the mammalian SNORF25 receptor, with the chemical compound under conditions suitable for activation of the mammalian SNORF25 receptor, and measuring the second messenger response in the presence and in the absence of the chemical compound, a change in the second messenger response in the presence of the chemical compound indicating that the compound activates the mammalian SNORF25 receptor; wherein (1) the mammalian SNORF25 receptor has an amino acid sequence greater than 95% identical to the amino acid sequence shown in SEQ ID NO: 2 or that encoded by the plasmid pEXJT3T7-hSNORF25 (ATCC Accession No. 203495); or 2) the mammalian SNORF25 receptor has an amino acid sequence greater than 95% identical to the amino acid sequence shown in SEQ ID NO: 4 or that encoded by the plasmid pcDNA3.1-rSNORF25 (ATCC Accession No. 203494); or 3) the mammalian SNORF25 receptor has an amino acid sequence greater than 95% identical to the amino acid sequence shown in SEQ ID NO: 25 or that encoded by the plasmid pEXJ-mSNORF25-f (ATCC Patent Depository No. 2263).