Patent ID: 8685972

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or hydrate thereof, wherein: W represents CH; Z represents N; R 1 and R 2 independently represent H, C 1-4 alkyl, C 1-4 alkoxy, halogen or CF 3 ; R 4 and R 5 independently represent H or (CH 2 ) m â€”X, where m is 0 or 1 and X represents halogen, 5- or 6-membered heteroaryl which is optionally substituted with up to 2 C 1-4 alkyl groups, CN, CF 3 , R 6 , OR 6 , N(R 6 ) 2 , SO 2 R 6 , CO 2 R 6 or CON(R 6 ) 2 where each R 6 independently represents H, phenyl, C 1-4 alkyl or hydroxyC 1-4 alkyl or two R 6 groups attached to the same nitrogen optionally complete an N-heterocycle; and Ar represents a phenyl or 5- or 6-membered heteroaryl ring bearing from 2 to 4 substituents selected from: (a) C 1-6 alkyl; (b) C 3-6 cycloalkyl; (d) C 3-6 cycloalkyl C 1-6 alkyl; (e) C 2-6 alkenyl; (f) OR 7 ; (g) CO 2 R 7 ; (h) N(R 7 ) 2 (i) SR 7 ; and (j) CF 3 ; where each R 7 represents C 1-6 alkyl.