Patent ID: 8513242

Claim:
A compound of formula I: including a pharmaceutically acceptable salt, prodrug or N-oxide thereof, wherein: X 2 is CR 2 or N, X 3 is CR 3 or N, X 4 is CR 4 or N, X 5 is CR 5 or N, and X 6 is CR 6 or N, where no more than two of X 2 -X 6 are N; W is C 4 -C 10 cycloalkyl substituted with one or two substituents independently selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, —OC 1 -C 6 alkyl, —O—C 3 -C 10 cycloalkyl, —CF 3 , and fluoro; R 1 and R 11 are independently hydrogen, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocycloalkyl, —OC 1 -C 6 alkyl-O—C 1 -C 10 cycloalkyl, —O—C 1 -C 10 heterocycloalkyl, —O—C(R 12 )(R 13 )—C 1 -C 10 heterocycloalkyl, —O-aryl, —O-heteroaryl, —O—C(R 12 )(R 13 )-aryl, or —O—C(R 12 )(R 13 )-heteroaryl; R 2 and R 6 are independently hydrogen, F, Br, I, —CF 3 , —OCF 3 , —OCHF 2 , —OCH 2 F, C 2 -C 6 alkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, —OC 1 -C 6 alkyl, —-O—C 3 -C 10 cycloalkyl, —CN, aryl, or heteroaryl; R 3 and R 5 are independently hydrogen, halogen, —CF 3 , —OCF 3 , —OCHF 2 , —OCH 2 F, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, —OC 1 -C 6 alkyl, —O—C 3 -C 10 cycloalkyl, —CN, aryl, or heteroaryl; R 4 is hydrogen, F, Cl, Br, I, —CF 3 , —CN, —OCHF 2 , —OCH 2 F, —OCF 3 , C 1 -C 10 alkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, —OC 1 -C 10 alkyl, —OC 3 -C 10 cycloalkyl, —OC 3 -C 10 heterocycloalkyl, —SC 1 -C 10 alkyl, —SC 3 -C 10 cycloalkyl, aryl, or heteroaryl; R 12 and R 13 each represent independently for each occurrence H, methyl, ethyl, n-propyl, isopropyl, or cyclopropyl; n is 1, 2, or 3; where at least one of R 2 , R 3 , R 4 , R 5 , and R 6 is not hydrogen; where R 3 is not morpholino or pyridyl; and where if R 4 is —CH 3 , —OCF 3 , —OCH 3 , F, or Cl, then W is not unsubstituted cyclohexyl or unsubstituted cyclopropyl, or R 1 is not hydrogen.