Patent ID: 7468394

Claim:
A process for obtaining a sterile pharmaceutical composition for a solution of propofol emulsion having a microbial growth retardation and comprising emulsion particles, liposome particles and a supporting aqueous phase, wherein said process comprises the following steps: a) mix organic phase: propofol, oil and egg lecithin, b) mix aqueous phase: water and glycerin, c) mix phase a) and phase b), and adjust pH, d) entrap sufficient propofol within shells of liposome particles and allow the entrapped propofol in the liposome shells to reach or be close to the equilibrium of the propofol among the emulsion particles, the aqueous phase and the liposome particles, e) emulsify by use of a homogenizer, f) adjust final volume and pH, g) fill, close and seal, h) terminally sterilize, i) perform a candling procedure, and j) package.