Patent ID: 6913926

Claim:
A method of inhibiting neoplastic cellular proliferation or transformation of both, in vitro is comprising: providing a mammalian cell, in vitro, that endogenously overexpresses PTTG1; and delivering to a mammalian cell a composition comprising an expression vector comprising a promoter and a polynucleotide, said polynucleotide comprising a first DNA segment encoding a mammalian PTTG2 peptide consisting of amino acid residues 1-191 of SEQ ID NO:64, said polynucleotide being operatively linked to the promoter in a transcriptional unit, said expression vector being complexed with a cellular uptake-enhancing agent, in an amount and under conditions sufficient to enter the cell, such that the PTTG2 peptide is expressed in the cell, whereby neoplastic cellular proliferation or transformation or both, of the cell is inhibited.