Patent ID: 8476416

Claim:
An immunostimulatory oligonucleotide compound comprising a sequence of formula (II): 5′-Um . . . U1-X1-X2-Y-Z-X3-X4-D1 . . . Dm-3′ (II) wherein Y is a non-natural pyrimidine nucleoside selected from 5-hydroxycytosine, 5-hydroxymethylcytosine, N4-alkylcytosine and 4-thiouracil; Z is guanosine, 2′-deoxyguanosine or a guanosine analog; each X independently is a naturally occurring deoxyribonucleoside or an immunostimulatory moiety; wherein Um . . . U1 represents an upstream potentiation domain, where each U independently is a naturally occurring deoxyribonucleoside or an immunostimulatory moiety; wherein D1 . . . Dm represents a downstream potentiation domain, where each D independently is a naturally occurring deoxyribonucleoside or an immunostimulatory moiety; wherein the terminal D is a C3 linker, and wherein the C3 linker may optionally be branched or unbranched, and optionally may be substituted or unsubstituted, and optionally a chirally pure or a racemic mixture; and wherein m, at each occurrence, represents a number from 0-30.