Patent ID: 7132434

Claim:
A compound of the formula I or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof wherein X is selected from CO, CS or CR1R2; Z is selected from SO2N(R3) or N(R4)SO2 n is 0; m is 0; R1 and R2 are each independently selected from H or C1–6 alkyl; R3 and R4 are each independently selected from H, C1–6 alkyl, phenyl-C1–6 alkyl, or heteroaryl-C1–6 alkyl; R5 is a dicyclic group of the following formula; wherein G1 is phenyl or pyridyl; G2 is phenyl, piperidyl, piperazinyl, or pyrrolidinyl and B is a direct bond, wherein each of G1 and G2 is independently optionally substituted by one or more substituents independently selected from halogen, C1–6 alkyl, C2–6 alkenyl, C1–6 haloalkyl, C1–6 alkoxy, C1–6 haloalkoxy, thiolo, C1–6 thioloalkyl, C1–6 thiolo-haloalkyl, sulfono, C1–6 sulfonoalkyl, C1–6 sulfono-haloalkyl, aminosulfonyl, sulfoxy, C1–6 sulfoxyalkyl, amino, cyanoamino, hydrazine, C1–6 aminoalkyl, aminocarbonylamine, methylsulfonamine, acetamido, N-(C1–3 alkyl)acetamido, carboxamide, N(C1–3 alkyl)carboxamide, N,N -di-(C1–3 alkyl)carbamate, cyano, C1–6 cyanoalkyl, hydroxy, nitro, nitroso, formyl, N-methylformamide, methylformate, ethylformate, acetyl, acetoxy.