Patent ID: 6973388

Claim:
A method for diagnosing a level of a disease state of a subject, said method comprising (1) determining, for said disease state, an interpolated response profile for which similarity is greatest between a diagnostic profile and said determined interpolated response profile, said diagnostic profile comprising measurements of a first plurality of cellular constituents in one or more cells of said subject, and said determined interpolated response profile comprising measurements of a second plurality of cellular constituents comprising at least a portion of said first plurality, each said measurement being extracted from an interpolate response curve of said measurement as a function of level of said disease state, wherein said interpolated response curve is obtained by a method comprising (i) providing response profiles of one or more cells of one or more analogous subjects for said disease state, wherein each of said response profiles comprises measurements of said second plurality of cellular constituents in one or more cells of one of said one or more analogous subjects at one of a plurality of levels of said disease state, and (ii) interpolating measurements of each said cellular constituent in said response profiles over said plurality of levels of said disease state to generate an interpolated response curve so that an interpolated response profile comprising measurements of said portion of said first plurality of cellular constituents at a same level of said disease state may be extracted over a range of levels of said disease state, wherein the level of disease state correlated to said determined interpolated response profile indicates said level of said disease state of said subject; (2) determining statistical significance of said similarity between said determined interpolated response profile and said diagnostic profile; and (3) diagnosing said patient as having said level of said disease correlated to said determined interpolated response profile if said statistical significance is at least 95%.