Patent ID: 7619111

Claim:
A stereoselective method for preparing a fluorinated molecule having a fluorine atom carried by an asymmetric carbon atom having the (R) or (S) configuration, located a to an ester or ketone group, said method comprising: (i) introducing into a reactor a single enantiomer of a fluorosulfite compound having a given configuration at the C* carrying the fluorosulfite group, of formula (III) (2i) conducting thermal decomposition of the fluorosulfite compound in the presence of a nucleophilic catalyst, and (3i) recovering the resulting single enantiomer fluorinated molecule, having the inverse configuration at the C*, of formula (IV) wherein: C* represents a chiral carbon; R 1 represents an alkyl, alkenyl or alkynyl group, which is linear or branched, or an aryl, cycloalkyl or alkylcycloalkyl group, —CO 2 R 5 , —(CH 2 ) n —CO 2 R 5 , —COR 5 , —SOR 5 or —SO 2 R 5 ; n is an integer from 1 to 12; R 5 is hydrogen or an alkyl, alkenyl or alkynyl group, which is linear or branched, or a cycloalkyl, alkylcycloalkyl, aryl or substituted aryl group; or R 1 forms an aromatic or non-aromatic heterocyclic ring having in place of one or more carbon atoms one or more hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen; R 2 represents hydrogen or a member selected from the group defined for R 1 ; R 1 and R 2 are different; and R 3 represents hydrogen or a group R 6 or —OR 6 , wherein R 6 is a member selected from the group defined for R 5 , wherein R 6 and R 1 are identical or different.