Patent ID: 7402579

Claim:
A compound having formula 2 or a pharmaceutically acceptable salt or ester thereof; wherein A is NR 1 R 2 ; Z is O; and U is NR 1 R 2 ; B is a 5-6 membered aryl or heteroaryl; R 1 is independently H or a C 1-6 alkyl; and R 2 is independently H, or a C 1-10 alkyl or C 2-10 alkenyl optionally containing one or more non-adjacent heteroatoms selected from N, O, and S, and optionally substituted with a substituted or unsubstituted aryl, heteroaryl, carbocyclic, or heterocyclic ring; or R 2 is an optionally substituted cycloalkyl, heterocyclic ring, aryl or heteroaryl; or R 1 and R 2 together with N in NR 1 R 2 may independently form an optionally substituted 5-6 membered ring containing N, and optionally O or S; R 5 is a substituent at any position of B and is H, halo, cyano, azido, —CONHR 1 , OR 2 , or C 1-6 alkyl or C 2-6 alkenyl, where each C 1-6 alkyl or C 2-6 alkenyl is optionally substituted by halo, ═O or one or more heteroatoms; wherein each optionally substituted moiety is substituted with one or more halo, cyano, azido, acetyl, amido, OR 2 , NR 1 R 2 , carbamate, C 1-10 alkyl, or C 2-10 alkenyl, where each C 1-6 alkyl or C 2-6 alkenyl is optionally substituted by halo, ═O, aryl or one or more heteroatoms selected from N, O and S; or is substituted with an aryl, a carbocyclic or a heterocyclic ring.