Patent ID: 8592456

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is aryl, heteroaryl, cycloalkyl, heterocyclyl or alkyl, which is optionally substituted by one or more substituents R′, and which R 1 is not piperidinyl; Ar is aryl, cycloalkyl, heterocyclyl or heteroaryl, which is optionally substituted by one or more substituents R′; Z is H, halogen, —CR″O, —N(R″) 2 , —CN, —C(S)R″, —N═C(R′) 2 , —CO 2 R″, —NR′CO 2 R″, —CONHR″, —CON(R″) 2 , —COSR″, —CSNHR″, —CSN(R″) 2 , —SO 2 -alkyl, —SO 2 -haloalkyl, —SO 2 NHR″, —SO 2 (NR″) 2 , amino or —SO 2 R″; Y is H, halogen, haloalkyl, or alkyl, which is optionally substituted by one or more substituents R′; R′ each independently represents H, —CO 2 R″, —CONHR″, —CR″O, —SO 2 N(R″) 2 , —SO 2 NHR″, —NR″—CO-haloalkyl, —NO 2 , —NR″—SO 2 -haloalkyl, —NR″—SO 2 -alkyl, —SO 2 -alkyl, —NR″—CO-alkyl, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkoxy, amino, heterocyclyl, aryl, haloaryl, haloarylalkyl, arylalkyl or heteroaryl; and R″ each independently represents H, haloalkyl, hydroxyalkyl, amino, alkoxy, —N═C(R′) 2 , —NR′—CO—R′, —CR′O, —CO 2 R′, alkyl, cycloalkyl, aryl, haloaryl, haloarylalkyl, heteroaryl, heterocyclyl, arylalkyl or aminoalkyl, which are optionally substituted by one or more substituents R′; wherein R 1 , Ar, Z and Y may not comprise more than three coupled substituents R′ and/or R″.