Patent ID: 7312215

Claim:
A compound of the formula: Y is O or S; A is C═O, C 1 -C 3 alkyl, NR 7 or a direct bond; B is C═O or NR 7 provided that A and B are not both —NR 7 ; R 1 , R 2 , R 4 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of H, C 1-6 alkyl, alkenyl, alkynyl, cycloalkyl, halo, amino, aminoalkyl, alkoxy, thioalkoxy, nitro, aryl, alkoxyalkyl, thioalkoxyalkyl, aminoalkyl, aralkyl, —CN, —CO 2 R 8 , —CONR 9 R 10 , —CO 2 NR 11 R 12 , —NR 13 CONR 14 R 15 , —NR 16 SO 2 R 17 , —SO 2 NR 18 R 19 , —C(NR 20 )NR 21 R 22 , —NH-Z, and —NH-Z-aryl; R3 is morpholinyl; Z is selected from the group consisting of C 1 -C 4 alkyl, alkenyl, and alkynyl; Z optionally substituted with one or more hydroxy, thiol, alkoxy, thioalkoxy, amino, halo, NR 23 SO 2 R 24 , —CO, —CNOH, —CNOR 26 , —CNNR 27 , —CNNCOR 28 and —CNNSO 2 R 29 ; and R 8 , R 9 , R 10 , R 11 , R 12 , R 13 R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , and R 26 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, hydroxy, alkoxy, aryl, and alkyl-R 25 wherein R 25 is alkenyl, hydroxy, thiol, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, aryl, cyano, halo, sulfoxy, sulfonyl, —NR 27 COOR 28 , —NR 29 C(O)R 30 , —NR 31 SO 2 R 32 , SO 2 NR 31 R 32 —C(O)NR 33 R 34 , and R 27 , R 28 , R 29 , R 30 , R 31 , R 32 , R 33 and R 34 are, independently, hydrogen, alkyl, or cycloalkyl.