Patent ID: 8785438

Claim:
A method for inhibiting a tumor treatable by inhibiting the mammalian target of rapamycin (mTOR), comprising administering a therapeutically effective amount of a compound of formula (I) or a pharmacologically acceptable salt thereof to a subject in need thereof, the compound of formula (I) having the structure: wherein A is an 8- to 10-membered partially saturated or aromatic fused bicyclic nitrogen-containing heterocyclic group having 1 to 3 nitrogen atoms, A may have the same or different n R1s as substituents, R1 is a substituent selected from the group consisting of a hydroxy group, a halogen atom, a cyano group, an oxo group, a C1-4 alkyl group (wherein the C1-4 alkyl group may be substituted with one or two same or different C1-4 alkoxy groups or —NR7aR7bs), a C1-4 alkoxy group, a halogeno-C1-4 alkyl group, —NR7aR7b, —C(O)R8 and —C(O)NR9aR9b, n is any integer of 0 to 3, R7a, R7b, R9a and R9b are the same or different and are each a hydrogen atom or a C1-4 alkyl group (wherein the C1-4 alkyl group may be substituted with 1 or 2 hydroxy groups), R8 is a hydrogen atom, a hydroxy group, a C1-4 alkyl group or a C1-4 alkoxy group, B is a 3- to 7-membered saturated or partially saturated monocyclic hydrocarbon group and may contain 1 or 2 oxygen atoms, sulfur atoms, nitrogen atoms, sulfinyl groups and/or sulfonyl groups as ring constituents, B may have the same or different m R2s as substituents, R2 is a substituent present on a carbon atom or nitrogen atom forming B, R2 is a substituent selected from the group consisting of a hydroxy group, a halogen atom, a cyano group, an oxo group, a C1-4 alkyl group (wherein the C1-4 alkyl group may be substituted with 1 or 2 C1-4 alkoxy groups), a C1-4 alkoxy group, a halogeno-C1-4 alkyl group, a C1-4 alkylsulfonyl group, a C1-4 alkylcarbonyl group and —NR10aR10b when R2 is a substituent present on a carbon atom forming B, and R2 is a substituent selected from the group consisting of a hydroxy group, a C1-4 alkyl group (wherein the C1-4 alkyl group may be substituted with 1 or 2 C1-4 alkoxy groups), a C1-4 alkoxy group, a halogeno-C1-4 alkyl group, a C1-4 alkylsulfonyl group, a C1-4 alkylcarbonyl group and —NR10aR10b when R2 is a substituent present on a nitrogen atom forming B, R10a and R10b are the same or different and are each a hydrogen atom or a C1-4 alkyl group, m is any integer of 0 to 3, Q is a bond or a C1-4 alkylene group, R3 and R4 are the same or different and are each a hydrogen atom, a halogen atom, a C1-4 alkyl group, a halogeno-C1-4 alkyl group or a cyano group, and R5 and R6 are the same or different and are each a hydrogen atom, a halogen atom or a C1-4 alkyl group, or R5 and R6 together may form an oxo group or together with the carbon atom to which R5 and R6 are bonded may form a C3-8 cycloalkyl group.