Patent ID: 8906379

Claim:
A conjugate comprising: (1) a therapeutic glycoprotein (G), (2) a masking moiety (M) capable of reducing or blocking binding of the glycoprotein to its cognate receptor, wherein the masking moiety is covalently linked to the glycoprotein through a first linker (L 1 ), and (3) a targeting moiety (T) covalently linked to the masking moiety through a second linker (L 2 ), wherein: the conjugate has formula G(L 1 -M(L 2 -T) n ) m , wherein 2≦m≦16, and n<1 or 1<n≦20; the glycoprotein is released from the conjugate under lysosomal conditions; and at least one of L 1 and L 2 comprises a formula chosen from: wherein: 2≦p≦12 and 2≦q≦12, Ar is aryl or heteroaryl, and one or more of the terminal atoms of the formula may be derived from the element G, M, or T to which the atoms are attached.