Patent ID: 8877747

Claim:
An indenone derivative of formula (I) or a pharmaceutically acceptable salt thereof: wherein, n is 0, 1 or 2; X is one or more substituents introduced to the ortho-, meta- or para-position of the phenyl group, each selected independently from the group consisting of hydrogen, halogen, —CN, —CF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 3-10 cycloalkyl, and C 3-8 cycloalkoxy; R 1 is C 6-10 aryl substituted with at least one substituent selected from the group consisting of halogen, oxo, —CF 3 , —CN, amino, hydroxy, carboxy, carbamoyl, nitro, thiol, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 3-10 cycloalkyl, C 3-8 cycloalkoxy, C 6-10 aryl, C 6-10 aryloxy, —C(O)R 4 , —C(O)OR 4 , —C(O)NR 4 R 5 , —S(O)R 4 , —S(O 2 )R 4 , —S(O 2 )NR 4 R 5 , —NR 4 R 5 , and —NR 4 C(O)R 5 , R 4 and R 5 being each independently hydrogen, C 1-6 alkyl, or C 3-10 cycloalkyl; or 5 to 10-membered heteroaryl; Y is CH, N, N + (—C 1-6 alkyl), or N + (—O − ); and R 2 and R 3 are each independently hydrogen, C 1-6 alkyl, C 1-6 alkoxy, C 6-10 aryl, or 5 to 10-membered heteroaryl, or are fused together with Y to form C 3-10 cycloalkyl or 5 to 10-membered heterocycloalkyl, in which the C 6-10 aryl of R 2 and R 3 , 5 to 10-membered heteroaryl, C 3-10 cycloalkyl, and 5 to 10-membered heterocycloalkyl are each independently and optionally substituted with at least one substituent selected from the group consisting of halogen, oxo, —CF 3 , —CN, amino, hydroxy, carboxy, carbamoyl, nitro, thiol, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 3-10 cycloalkyl, C 3-8 cycloalkoxy, C 6-10 aryl, C 6-10 aryloxy, —C(O)R 4 , —C(O)OR 4 , —C(O)NR 4 R 5 , —S(O)R 4 , —S(O 2 )R 4 , —S(O 2 )NR 4 R 5 , —NR 4 R 5 , and —NR 4 C(O)R 5 , R 4 and R 5 being each independently hydrogen, C 1-6 alkyl, or C 3-10 cycloalkyl.