Patent ID: 8008250

Claim:
A compound of the formula in which R 1 is (CH 2 ) k N(R a )R b , in which k is 0, 1 or 2; and either R a and R b , independently, are hydrogen or an optionally substituted (C 1-8 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, aryl, aryl(C 1-4 )alkyl, heteroaryl, heteroaryl-(C 1-4 )alkyl, chroman-4-yl, isochroman-4-yl, thiochroman-4-yl, isothiochroman-4-yl, 1,1-dioxo-1lambda*6*-thiochroman-4-yl, 2,2-dioxo-2lambda*6*-isothiochroman-4-yl, 1,2,3,4-tetrahydroquinol-4-yl, 1,2,3,4-tetrahydroisoquinol-4-yl, 1,2,3,4-tetrahydronaphth-1-yl, 1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1,2]thiazin-4-yl, 2,2-dioxo-1,2,3,4-tetrahydro-2lambda*6*-benzo[c][1,2]thiazin-4-yl, 1,1-dioxo-3,4-dihydro-1H-1lambda*6*-benzo[c][1,2]oxathiin-4-yl, 2,2-dioxo-3,4-dihydro-2H-2lambda*6*-benzo[e][1,2]oxathiin-4-yl, 2,3,4,5-tetrahydrobenzo[b]oxepin-5-yl or 1,3,4,5-tetrahydrobenzo[c]oxepin-5-yl group or R a and R b , together with the nitrogen, to which they are attached, form an optionally substituted pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or piperazinyl group; R 3 is hydrogen or (C 1-4 )alkyl; either V 1 is hydrogen and V 2 is hydroxyl; or V 1 and V 2 together are oxo; X 1 is (C 1-8 )alkylene; X 2 is (C 1-8 )alkylene, O, S, C(═O), C(═O)O, OC(═O), C(═O)N(R 2 )—(C 1-8 )alkylenoxy attached via its carbonyl function to Y and attached via the oxygen atom of its alkylenoxy moiety to Ar, N(R 2 )C(═O), C(═O)N(R 2 ) or N(R 2 ), in which R 2 is hydrogen or (C 1-4 )alkyl; Y is (C 1-10 )alkylene, (C 1-8 )alkylenoxy(C 1-6 )alkylene, (C 1-10 )alkenylene or (C 1-8 )alkenylenoxy-(C 1-6 )alkylene; Ar is phenylene to which X 1 and X 2 are attached in meta or para position to each other; and either Z is C(═O), AA is N[(C 1-4 )alkyl or (C 3-7 )cycloalkyl]CH(CH 3 )C(═O) and n is 1; or Z is S(═O) 2 , AA is CH 2 CH[(C 1-4 )alkyl]C(═O), and n is 1, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form.