Patent ID: 8207174

Claim:
A compound of formula II wherein the dotted bond represents a single or a double bond; R1 and R2 are selected from the group consisting of hydrogen, halogen, hydroxyl, carboxy, carbamoyl, sulfamoyl, cyano, nitro, NR6R7, alkyl, alkoxy, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylamino, alkylaminocarbonyl, arylsulfonylaminomethyl, heteroarylsulfonylaminomethyl and alkylaminosulfonyl, provided that if R1 is different from hydroxyl or hydroxymethyl, then R2 must represent hydroxyl or hydroxymethyl; R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, carboxy, carbamoyl, sulfamoyl, cyano, nitro, NR6R7, alkyl, alkoxy, alkylcarbonyl, and alkoxycarbonyl; R4 is hydrogen, alkylcarbonyl, or alkyl; R5 is selected from the group consisting of hydrogen, and alkyl, wherein alkyl is unsubstituted or substituted with one or more residues, which are optionally selected from the group consisting of hydroxyl, alkoxy, fluoro, and NR6R7; R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, aryl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, arylcarbonyl, and heteroarylcarbonyl; wherein each alkyl is unsubstituted or substituted with one or more residues, which are optionally selected from the group consisting of hydroxyl, alkoxy, phenyl, fluoro, carboxy, and NR16R17; and wherein R6 and R7 optionally form a 5-7 membered cycle; and wherein each aryl or heteroaryl is a monocyclic aromatic or heteroaromatic ring, respectively, which can be unsubstituted or substituted with one or more residues, which are optionally selected from the group consisting of hydroxyl, alkoxy, halogen, alkyl, carboxy, NR16R17, cyano and nitro; R8 is selected from the group consisting of hydrogen, alkyl, hydroxyl, and alkoxy; R9 and R10 are independently selected from the group consisting of hydrogen, carboxy, NR6R7, alkyl and a mono- or bicyclic aromatic or heteroaromatic ring; and R16 and R17 are independently selected from the group consisting of hydrogen, C1-C8 alkyl, phenyl, thienyl, pyridyl, C1-C8 alkylsulfonyl, phenylsulfonyl, thienylsulfonyl, pyridylsulfonyl, C1-C8 alkylcarbonyl, C1-C8 alkoxycarbonyl, aminocarbonyl, C1-C8 alkylaminocarbonyl, thienylcarbonyl, pyridylcarbonyl, and phenylcarbonyl, and wherein R16 and R17 optionally form a 5-7 membered cycle; or a pharmaceutically acceptable salt thereof.