Patent ID: 7884207

Claim:
A compound of the Formula (I): wherein: m is an integer from 1 to 5; R′ is selected from the group consisting of: hydroxy, thiol, —S(O) 0-2 -alkyl, —S(O) 2 —NH—R 9 , alkoxy, —O—C 1-3 alkylene-S(O) 2 -alkyl, —N(R 9 ) 2 , and —NH-Q-R 4 ; Z is selected from the group consisting of: a bond, C 1-3 alkylene, A′ is selected from the group consisting of: —O—, —C(O)—, —N(R 8 )—, —N(Q-R 4 )—, —N(C 1-5 alkylene-NH-Q-R 4 )—, —N(C 1-5 alkylene-W—NH—R 8 )—, and —S(O) 0-2 ; R 2 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, hydroxyalkylenyl, and —X—Y-alkyl wherein X is C 1-2 alkylene, and Y is selected from the group consisting of —N(R 8 )—SO 2 —, —N(R 8 ) —C(R 6 )—, and —N(R 8 )—SO 2 —N(R 8 )—; when taken together, R A and R B form a fused aryl ring wherein the aryl ring is unsubstituted or substituted by one or more R groups; or when taken together, R A and R B form a fused 5 to 7 membered saturated ring, optionally substituted by one or more R groups; R is selected from the group consisting of: halogen, hydroxy, alkyl, alkenyl, haloalkyl, alkoxy, alkylthio, and -N(R 9 ) 2 ; R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl, wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, acetylamino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo; R 6 is selected from the group consisting of ═O and ═S; R 8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and arylalkylenyl; R 9 is selected from the group consisting of hydrogen and alkyl; R 11 is selected from the group consisting of hydrogen, alkyl, halogen, and trifluoromethyl; R 12 is selected from the group consisting of hydrogen, alkyl, phenyl, 2-pyridyl, 3-pyridyl, and 4-pyridyl; x and y are each independently 0, 1, or 2 with the proviso that x+y is ≦2; Q is selected from the group consisting of a bond, —C(R 6 )—, —C(R 6 )—C(R 6 ), —S(O) 2 —, —C(R 6 )—N(R 8 )—W—, —S(O) 2 —N(R 8 )—, —C(R 6 )—O—, and —C(R 6 )—N(OR 9 )—; and W is selected from the group consisting of a bond, —C(O)—, and —S(O) 2 —; with the proviso that when Z is a bond or C 1-3 alkylene then R′ is other than —O—C 1-3 alkylene-S(O) 2 -alkyl; or a pharmaceutically acceptable salt thereof.