Patent ID: 6986735

Claim:
A method for producing a bioremodelable prosthetic tube construct comprising a layer of processed tissue matrix and a layer of dense fibrillar collagen wherein the method comprises: (a) flagging the processed tissue matrix on a sleeve-covered mandrel by hydrating one edge of the processed tissue matrix and contacting the sleeve-covered mandrel to the hydrated edge of the processed tissue matrix; (b) drying the flagged processed tissue matrix, wherein the flagged processed tissue matrix is flagged on the sleeve-covered mandrel; (c) rehydrating the flagged processed tissue matrix with a hydrating agent to form hydrated processed tissue matrix; (d) wrapping the hydrated processed tissue matrix around the mandrel at least one revolution and an additional percentage of the circumference to form one or more wrapped hydrated layers of processed tissue matrix; (e) dehydrating the layers of the processed tissue matrix; (f) removing the processed tissue matrix from the mandrel; (g) depositing a dense fibrillar collagen layer on the inside surface of the tube; and, (h) contacting the tube with a crosslinking agent to crosslink the collagen.