Patent ID: 8067418

Claim:
A compound of formula I, wherein X 1 represents —C(R 1a )(R 1b )—, —N(R 1a )— or —O—; the dotted line signifies an optional double bond; and in the case when the dotted line does not signify a double bond, X 2 and X 3 independently represent —C(R 1c )(R 1d )—, —N(R 1e )—, —O—, —C(O)— or —C(R 1f )(R 1g )—C(R 1h )(R 1j )— provided that: (i) when X 1 represents —N(R 1a )—, then X 2 and X 3 do not both represent —N(R 1e )—; (ii) when X 1 represents —O—, then X 2 and X 3 do not both represent —O—; (iii) when X 1 represents —O— and X 2 represents —N(R 1e )—, then X 3 represents —C(O)—; and (iv) when X 1 represents —O— and X 3 represents —N(R 1e )—, then X 2 does not represent —C(R 1c )(R 1d )—; or in the case when the dotted lines signifies a double bond, X 2 and X 3 independently represent —N— or —C(R 1c )—; R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 1g , R 1h and R 1j independently represent H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, Ar 1 , Het 1 , C 1-3 alkyl-Ar 2 , C 1-3 alkyl-Het 2 , C 1-3 alkoxy-Ar 3 , C 1-3 alkoxy-Het 3 , halo, —C(O)—C 1-6 alkyl, —C(O)—Ar 4 or —C(O)—Het 4 ; Ar 1 , Ar 2 , Ar 3 and Ar 4 each independently represent a C 6-10 aryl group, which group is optionally substituted by one or more substituents selected from ═O, —OH, cyano, halo, nitro, C 1-6 alkyl (optionally terminated by —N(H)C(O)OR 11a ), C 1-6 alkoxy, phenyl, —N(R 12a )R 12b , —C(O)R 12c , —C(O)OR 12d , —C(O)N(R 12e )R 12f , —N(R 12g )C(O)R 12h , —N(R 12i )C(O)N(R 12k , —N(R 12m )S(O) 2 R 11b , —S(O) p R 11C , —OS(O) 2 R 11d and —S(O) 2 N(R 12n )R 12p ; Het 1 , Het 2 , Het 3 and Het 4 each independently represent a four- to twelve-membered heterocyclic group containing one or more heteroatoms selected from oxygen, nitrogen and/or sulfur, which heterocyclic group is optionally substituted by one or more substituents selected from ═O, —OH, cyano, halo, nitro, C 1-6 alkyl (optionally terminated by —N(H)C(O)OR 11a ), C 1-6 alkoxy, phenyl, —N(R 12a )R 12b , —C(O)R 12c , —C(O)OR 12d , —C(O)N(R 12e )R 12f , —N(R 12g )C(O)R 12h , —N(R 12i )C(O)N(R 12j )R 12k , —N(R 12m )S(O) 2 R 11b , —S(O) p R 11c , —OS(O) 2 R 11d and —S(O) 2 N(R 12n )R 12p ; R 11a to R 11d independently represent C 1-6 alkyl; R 12a to R 12p independently represent H or C 1-6 alkyl; p represents 0, 1 or 2; A represents —C(O) or —CH 2 —; Y 1 , Y 2 , Y 3 and Y 4 independently represent —CH— or —CF—; Z 1 represents —S—; Z 2 represents —CH—; R 2 represents —S(O) 2 N(H)C(O)R 4 , —S(O) 2 N(H)S(O) 2 R 4 , —C(O)N(H)S(O) 2 R 4 , or, when Z 1 represents —CH═CH—, R 2 may represent —N(H)S(O) 2 N(H)C(O)R 5 or —N(H)C(O)N(H)S(O) 2 R 5 ; R 3 represents C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl or di-C 1-3 -alkylamino-C 1-4 -alkyl; R 4 represents C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 -alkyl, C 1-3 alkoxy-C 1-6 -alkoxy, C 1-6 alkylamino or di-C 1-6 alkylamino; and R 5 represents C 1-6 alkyl, or a pharmaceutically-acceptable salt thereof.