Patent ID: 7138144

Claim:
A method of inducing tolerance to a transplant transplanted from a donor to a subject, the method comprising: (a) administering myeloreduction or myeloablation treatment to the subject; (b) following step (a), restricting outflow of blood and/or lymph from a portion of the circulatory system of the subject; and (c) administering a dose of bone marrow cells derived from the donor to a body part delimiting said portion of the circulatory system, prior to, concomitantly with or following transplantation of the transplant, wherein said body part contains a bone marrow tissue, and wherein said restricting results in greater homing or retention of said dose of bone marrow cells in said bone marrow tissue relative to absence of said restricting, and does not cause ischemic injury to said bone marrow tissue, thereby inducing tolerance to the transplant in the subject.