Patent ID: 8088594

Claim:
An immunoassay for detecting active pharmaceutically anti-psychotic drugs selected from the group consisting of risperidone, paliperidone and mixtures thereof comprising providing a mixture containing a sample, a conjugate of a carrier with a ligand having the formula: wherein B is Y is an organic spacing group; X is a terminal functional group capable of binding to a carrier; and p is an integer from 0 to 1; and an antibody selectively reactive with said pharmaceutically active anti-psychotic drugs having little substantial reactivity with the pharmacologically inactive risperidone and paliperidone metabolite, 7-hydroxy-risperidone and having no substantial cross-reactivity with other pharmacologically inactive risperidone and paliperidone metabolites, said reactivity of said antibody with 7 hydroxy-risperidone being less than 40% and said cross reactivity of said antibody with the other pharmaceutically inactive metabolites being less than 5%, said reactivity and cross reactivity being based upon said antibody's combined reactivity with both risperidone and paliperidone, and causing the pharmaceutically active anti-psychotic drug and said conjugate in said sample to bind with said antibody and thereafter measuring the amount of said conjugate in said sample that is bond or unbound to said antibody whereby the presence of the anti-psychotic drugs in said sample can be detected.