Patent ID: 7456183

Claim:
A compound of formula I wherein X and Y are independently selected from the group consisting of CH 2 , N, NR 9 , C═O, C═S, and (CR 6 R 7 ) n ; n is 1; W is selected from the group consisting of L is selected from the group consisting of N, O, S, S═O, SO 2 , C(O), NC(O), NC(S), OC(O), OC(S), C(NR 10 ), C(NOR 10 ), and a covalent bond; Z 1 , Z 2 , and Z 3 are independently selected from the group consisting of CR 8 and N; R 1 is selected from the group consisting of substituted and unsubstituted arylalkyl, heteroarylalkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, heterocyclylalkyl, cycloalkylalkyl, alkenyl, alkynyl, and alkyl groups; R 2 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, aryl, and arylalkyl groups; R 3 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, heterocyclyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, and cycloalkylalkyl groups, or R 2 and R 3 may join together to form a ring containing at least two N atoms; R 4 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, and cycloalkylalkyl groups, or R 2 and R 4 may join together to form a ring containing at least two N atoms; R 5 is selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, and cycloalkylalkyl groups, or R 4 and R 5 , together with the nitrogen to which they are bound, form a substituted or unsubstituted heterocyclyl or heteroaryl group; R 6 and R 7 may be the same or different, and are each independently selected from the group consisting of H, Cl, I, F, Br, OH, NH 2 , CN, NO 2 , and substituted and unsubstituted alkoxy, amino, alkyl, alkenyl, alkynyl, alkylamino, dialkylamino, cycloalkyl, heterocyclylamino, heteroarylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, heterocyclylaminocarbonyl, and heteroarylaminocarbonyl groups; R 8 is independently selected from the group consisting of H, Cl, I, F, Br, OH, NH 2 , CN, NO 2 , and substituted and unsubstituted alkoxy, amino, alkyl, alkenyl, alkynyl, alkylamino, dialkylamino, cycloalkyl, heterocyclylamino, heteroarylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, heterocyclylaminocarbonyl, and heteroarylaminocarbonyl groups; R 9 and R 10 are independently selected from the group consisting of H, and substituted and unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, alkylcarbonyl, and arylcarbonyl groups; and pharmaceutically acceptable salts thereof, stereoisomers thereof, tautomers thereof, or hydrates thereof.