Patent ID: 8431595

Claim:
A compound of the formula wherein one of W and X can be N and the other can be C; Y is selected from the group consisting of S, O, CH 2 , CH(CH 3 ), CH(OH), C(CH 3 )(OH), C(CH 3 ) 2 , C(—U(CH 2 ) n U—), C((CH 2 ) n CH 3 ) 2 , C(O), NH, S(O), S(O) 2 , S(O)NH and S(O) 2 NH; U is selected from the group consisting of CH 2 , S, and O; n is an integer from 1 to 6; Z is selected from the group consisting of alkyl, cycloalkyl, and aryl, heteroaryl, and arylalkyl optionally substituted with up to three groups independently selected from a group consisting of halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, trifluoromethyl, carboxy, alkylcarboxy and carbamoyl; R 1 is selected from the group consisting of H, CH 3 , CH 2 CH 3 , aminoalkyl, morpholinoalkyl, and hemisuccinate; and R 2 is selected from the group consisting of H, alkyl optionally substituted with up to three groups independently selected from a group consisting of halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, trifluoromethyl, carboxy, alkylcarboxy and carbamoyl, cycloalkyl, aryl, heteroaryl and heterocycloalkyl optionally substituted with up to five groups independently selected from a group consisting of halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, trifluoromethyl, carboxy, alkylcarboxy and carbamoyl, and arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl and heteroarylalkyl, wherein the ring portion is optionally substituted with up to five groups independently selected from a group consisting of halo, alkyl, alkoxy, hydroxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, nitro, amino, alkylamino, dialkylamino, thiol, alkylthiol, trifluoromethyl, carboxy, alkylcarboxy and carbamoyl, and pharmaceutically acceptable salts thereof.