Patent ID: 7960366

Claim:
A pharmaceutical composition comprising an effective amount of a substituted tetracycline compound and an effective amount of an antifungal agent, and a pharmaceutically acceptable carrier, wherein the substituted tetracycline compound is of formula (I): wherein X is CR 6 ′R 6 ; R 2 and R 2 ′ are each hydrogen; R 4 ′ and R 4 ″ are each alkyl; R 4 is NR 4 ′R 4 ″; R 3 , R 10 , R 11 and R 12 are each hydrogen; R 5 is hydroxyl or hydrogen; R 6 and R 6 ′ are each independently hydrogen or alkyl; R 7 is unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted aryl, alkoxy, unsubstituted or substituted alkylcarbonyl, or —(CH 2 ) 0-3 NR 7c C(═W′)WR 7a ; R 9 is hydrogen; W is CR 7d R 7e , S, NR 7b or O; W′ is O, NR 7e or S; R 7a , R 7b , R 7c , R 7d and R 7e are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic or heteroaromatic; R 8 is hydrogen; further wherein said antifungal agent is selected from the group consisting of: fluconazole, itraconazole, ketoconazole, miconazole, clotrimazole, voriconazole, posaconazole, ravuconazole, natamycin, lucensomycin, nystatin, amphotericin B and caspofungin acetate, and further wherein said pharmaceutical composition is effective against one or more fungi selected from the group consisting of: Aspergillus flavus, Aspergillus fumigatus, Aspergillus terreus, Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans, Issatchenkia orientalis , and Saccharomyces cerevisiae.