Patent ID: 8802670

Claim:
A compound which is fused pyrimidine of formula (Ib′): wherein X is O or S; Y is N or —CH—; R 2 is H, halo or C 1 -C 6 alkyl; each R′ is, independently, H, C 1 -C 6 alkyl or hydroxy-C 1 -C 6 alkyl, or two groups R′ on the same carbon atom form an oxo (═O) group; or when Y is N, two groups R′ on different carbon atoms together form a —CH 2 — bridgehead; each R″ is, independently, H or C 1 -C 6 alkyl, or two groups R″ on the same carbon atom form an oxo (═O) group; Z is R 10 or -(alk) q -NR 11 R 12 ; R 10 is H, a C 3 -C 6 cycloalkyl group, C 1 -C 6 alkyl which is unsubstituted, or CF 3 ; R 11 and R 12 are each independently selected from H, C 1 -C 6 alkyl which is unsubstituted and -(alk) q -OR, or R 11 and R 12 together form, with the N atom to which they are attached, a 5- or 6-membered saturated N-containing heterocyclic group containing 0 or 1 additional heteroatoms selected from O, N and S; q is 0 or 1; r is 0 or 1; alk is C 1 -C 6 alkylene; and and R 3 is selected from: (a) a group of the following formula: wherein B is a phenyl ring which is unsubstituted or substituted and Z is selected from H, —OR, —SR, CH 2 OR, —CO 2 R, CF 2 OH, CH(CF 3 )OH, C(CF 3 ) 2 OH, —(CH 2 ) q OR, —(CH 2 ) q NR 2 , —C(O)N(R) 2 , —NR 2 , —NRC(O)R, —S(O) m N(R) 2 , —OC(O)R, OC(O)N(R) 2 , —NRS(O) m R, —NRC(O)N(R) 2 , CN, halogen and —NO 2 , wherein each R is independently selected from H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl and a 5- to 12-membered aryl or heteroaryl group, the group being unsubstituted or substituted, m is 1 or 2 and q is 0, 1 or 2; (b) a heteroaryl group which contains 1, 2, 3 or 4 ring nitrogen atoms and 0, 1 or 2 additional heteroatoms selected from O and S, which group is bicyclic and which is unsubstituted or substituted; and (c) a benzene ring which is unsubstituted or substituted and which is fused to a heteroaryl group as defined above; or a pharmaceutically acceptable salt thereof.