Patent ID: 8536320

Claim:
A tetrahydropyran nucleoside analog having Formula I: wherein: Bx is a heterocyclic base moiety; one of T 1 and T 2 is H or a hydroxyl protecting group and the other of T 1 and T 2 is H, a hydroxyl protecting group or a reactive phosphorus group selected from a phosphoramidite, an H-phosphonate, a phosphate triester or a phosphorus containing chiral auxiliary; Q is CH 2 F, CHF 2 , CF 3 , CH 2 CH 2 F, CH 2 CHF 2 , CH 2 CF 3 , or CH 2 C(═O)N(H)CH 3 ; q 1 and q 2 are each, independently, H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl; g 1 , g 2 , g 3 , g 4 , g 5 , and g 6 are each, independently, H, halogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl; wherein each substituted group comprises one or more optionally protected substituent groups independently selected from halogen, OJ 1 , NJ 1 J 2 , ═NJ 1 , SJ 1 , N 3 , CN, OC(═L)J 1 , OC(═L)NJ 1 J 2 and NJ 3 C(═L)NJ 1 J 2 , wherein each J 1 , J 2 and J 3 is, independently, H or C 1 -C 6 alkyl, and L is O, S or NJ 1 .