Patent ID: 8513461

Claim:
A method of treating or preventing blood loss, said method comprising administering to a subject in need thereof a compound of the formula (IV) wherein R 1 is optionally present one or more times and each R 1 is, independently, hydrogen or COOR 5 ; R 2 is a branched or linear alkyloxy residue comprising 1-6 carbon atoms, a branched or linear alkyloxycarbonylamido residue comprising 1-6 carbon atoms, or a polyethylene glycol residue of the formula (V) or (VI) with n as defined below; R 3 selected from the following residues: R 4 is optionally present one or more times and each R 4 is, independently, hydrogen or a halogen; R 5 is hydrogen, a branched or linear lower alkyl group comprising 1-6 carbon atoms, a branched or linear aminoalkyl residue comprising 1-6 carbon atoms, a halogen or pseudohalogen residue, or a polyethylene glycol residue of the formula (V) or (VI) CH 3 —O—(CH 2 —CH 2 —O—) n —CH 2 —CH 2 —(C═O)—NH—CH 2 (V) CH 3 —O—(CH 2 —CH 2 —O—) n —CH 2 —CH 2 —NH—(C═O)—CH 2 —CH 2 —(C═O)—NH—CH 2 (VI) wherein said polyethylene glycol residue has a molecular weight of from 750 Da to 10,000 Da and n is an integer from 25 to 250; o=1 or 2; p=1, 2, 3 or 4; i=0 or 1, in particular 0; and salts thereof.