Patent ID: 6900026

Claim:
A method for identifying in vivo antioxidant activity of a compound, said method comprising the steps of: (a) providing a first homozygous transgenic mouse in which the genes encoding Manganese Superoxide Dismutase (MnSOD) have been inactivated; (b) providing a second homozygous transgenic mouse in which the genes encoding Manoanese Superoxide Dismutase (MnSOD) have been inactivated of the same age as the first homozygous mouse; (c) administering the compound to said first mouse only; (d) determining lifespans of the first and second mice; and (e) identifying a in vivo antioxidant activity of the compound where the lifespan of the first mouse to which the compound has been administered is longer than that of the second mouse to which the compound has not been administered.