Patent ID: 7244577

Claim:
A method of screening for a modulator of LDL-receptor related protein-5 (LRP5) activity wherein the activity is selected from the group consisting of (1) LRP5 polypeptide binding and taking up LDL and (2) LRP5 polypeptide modulation of triglyceride and lipoprotein levels, which comprises: (a) providing a recombinant LRP5 polypeptide comprising the amino acid sequence shown in SEQ ID NO:3 or SEQ ID NO:4; (b) contacting the LRP5 polypeptide with a test substance (c) testing the activity of the LRP5 polypeptide with the test substance; and, (d) comparing the activity of the LRP5 polypeptide with the test substance to the activity of the LRP5 polypeptide without the test substance, wherein a difference in the activity indicates that the test substance modulates LRP5 activity.