Patent ID: 7902144

Claim:
A carrier molecule comprising: (a) at least one anthracycline, and (b) at least one albumin-affinitive substance selected from phthalocyanines, coumarins, flavonoids, tetracyclines, naphthalenes, aryl- and heteroarylcarboxylic acids, long-chain fatty acids, pyrroles, aromatic acids substituted with 2-5 chlorine atoms, aromatic acids substituted with 2-5 bromine atoms, aromatic acids substituted with 2-5 iodine atoms, organic dyes, benzophenones, phthalimides and isophthalimides, phthalic acids and isophthalic acids, quinolines and isoquinolines, anthraquinones, anthracenes, phenanthrenes, phenanthrolines, benzylidenes, diphenyls and biphenyls, indoles, indanes, hippuric acids, imidazoles and benzimidazoles, quinoxalines, pyridines, pyrimidines, piperidines, sarcosines, oxazoles, oxadiazoles, isoxazoles, pyrazoles, triazoles and tetrazoles, benzothiazoles, triazines, morpholines, chromenes, trisubstituted ethanoic and propanoic acids, tetrasubstituted ethanoic and propanoic acids, and pentasubstituted ethanoic and propanoic acids, stilbenes, tryptophan analog compounds, iodophenoxic acid, and 2,3,5-triiodobenzoic acid; wherein said albumin-affinitive substance binds non-covalently to albumin with an association constant K A relative to albumin greater than 10 3 M −1 via a non-covalent bond; and wherein said (a) anthracycline is linked to said (b) albumin-affinitive substance through an acid labile linkage selected from ester, acetal, ketal, imine, hydrazone, carboxylhydrazone, and sulfonylhydrazone linkages or through a linkage which is enzymatically cleavable within the body and which is not a peptide bond.