Patent ID: 8603483

Claim:
An antibody-drug conjugate of the formula: wherein the antibody is a human alphaV integrin specific antibody, and said antibody is capable of being internalized by a cell expressing said alphaV integrin, and wherein said antibody comprises (i) all of the heavy chain complementary determining region (CDR) amino acid sequences of CNTO 95 as shown in SEQ ID NOS: 1, 2, and 3, and (ii) all of the light chain CDR amino acid sequences of CNTO 95 as shown in SEQ ID NOS: 4, 5, and 6; and wherein the maytansinol is esterified at C-3; R 1 and R 2 are Me; X 1 and X 2 are H n is 2; p is 2; and m is 3-4, and the pharmaceutically acceptable salts and esters thereof.