Patent ID: 7390663

Claim:
A process for preparing a whole blood calibrator/control for calibrating glucose measuring systems over an extended period of time comprising: supplying a whole blood sample including a cellular component and a plasma component; forming a whole blood suspension by addition of an anticoagulant to said whole blood sample and metabolizing said suspension to a glucose concentration of less than about 20 mg/dL; treating said suspension to separate said plasma from said cellular component to form a concentrated cellular component; combining said concentrated cellular component with a predetermined amount of a non-crosslinking glycolytic inhibitor solution, to form a treated cellular dilution; incubating said treated cellular dilution whereby a further reduction in glucose concentration is obtained; washing said treated cellular dilution with at least one buffer solution effective to substantially remove said glycolytic inhibitor solution; preparing a stable whole blood suspension by intermixing said treated and washed cellular dilution and plasma in amounts effective to form a stable reconstituted whole blood sample; and formulating said stable reconstituted whole blood sample to contain a particular final glucose concentration; whereby said particular final glucose concentration remains substantially constant over time, thereby providing a stable glucose control/calibrator for use in glucose measuring systems.