Patent ID: 7348308

Claim:
A peptide inhibitor of glycogen synthase kinase-3 (GSK-3), comprising a polypeptide having between 7 and 20 amino acid residues and the amino acid sequence XZXXXS(p)X, wherein: S(p)=phosphorylated serine or threonine, X=any amino avid, whereas at least one of X between the Z residue and the S(p) residue is a proline residue, and Z=alanine, said amino acid sequence being a part of a substrate of GSK-3 containing a single SXXXS(p) recognition motif, wherein S is serine or threonine and S(p) is a phosphorylated serine or threonine, in which S is replaced by said Z, with the proviso that the polypeptide does not contain two or more SXXXS motifs, wherein S=serine, upstream of the S(p) residue, said polypeptide being capable of inhibiting the enzymatic activity of GSK-3.