Patent ID: 7803819

Claim:
A compound of formula (I) wherein R 1 is CN, R 2 is —C(R 3 ,R 4 )—(CH 2 ) n —R 5 , —C(R 3 ,R 4 )—CH 2 —NH—R 6 , —C(R 3 ,R 4 )—CH 2 —O—R 7 ; or tetralinyl, tetrahydroquinolinyl or tetrahydroisoquinolinyl, which tetralinyl, tetrahydroquinolinyl or tetrahydroisoquinolinyl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF 3 , R 3 is hydrogen, lower-alkyl, benzyl, hydroxybenzyl or indolylmethylene, R 4 is hydrogen or lower-alkyl, or R 3 and R 4 are bonded to each other to form a ring together with the carbon atom to which they are attached and —R 3 —R 4 — is —(CH 2 ) 2-5 —, R 5 is 5-membered heteroaryl, bi- or tricyclic heterocyclyl, or aminophenyl; which can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, CF 3 , trifluoroacetyl, thiophenyl, phenyl, heteroaryl and monocyclic heterocyclyl, which phenyl, heteroaryl or monocyclic heterocyclyl can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, benzyloxy, halogen, CF 3 , CF 3 —O, CN and NH—CO— lower-alkyl, R 6 is a) pyridinyl or pyrimidinyl, which is substituted with 1 to 3 substituents independently selected from the group consisting of aryl and heteroaryl, which aryl or heteroaryl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF 3 , or b) 5-membered heteroaryl or bi- or tricyclic heterocyclyl, which 5-membered heteroaryl or bi- or tricyclic heterocyclyl can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, carbonyl, aryl and heteroaryl, which aryl or heteroaryl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF 3 , and which carbonyl group can be unsubstituted or substituted with lower -alkyl, lower-alkoxy, halogen, CN, CF 3 , aryl, or heteroaryl, which aryl or heteroaryl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF 3 , R 7 is aminophenyl, naphthyl or quinolinyl, which can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN and CF 3 , X is C(R 8 ,R 9 ) or S, R 8 and R 9 independently from each other are H or lower-alkyl, n is 0, 1 or 2, and pharmaceutically acceptable salts thereof.