Patent ID: 7998980

Claim:
A method for inhibiting TRPV3 in a cell, comprising contacting said cell with an effective amount of a compound of Formula I or a salt thereof: wherein: R 1 , R 2 , R 3 and R 4 each independently represents H or a substituent selected from the group consisting of acylamino, aldehyde, alkenyl, alkoxyl, alkyl, alkylthio, alkynyl, amidino, amido, amino, aralkyl, aryl, azido, carbonyl, carboxyl, CF 3 , —CH═CF 2 , —CH 2 CH═CF 2 , cyano, cycloalkyl, cycloalkylalkyl, ester, formyl, halogen, heteroaralkyl, heteroaryl, heterocyclyl, heterocyclylalkyl, hydroxyl, ketone, nitro, phosphate, phosphoryl, silyl, sulfamoyl, sulfate, sulfhydryl, sulfonamido, sulfonate, sulfonyl, sulfonylamino, sulfoxido, thiocarbonyl, thiocarboxylate, thioester, thioether, and thioformate; X represents S or O; n represents 1 or 2 when X is O, or n represents 1 when X is S; m represents 0, 1, 2, 3, or 4; R 5 represents, independently for each occurrence, a substituent selected from the group consisting of acylamino, aldehyde, alkenyl, alkoxyl, alkyl, alkylthio, alkynyl, amidino, amido, amino, aralkyl, aryl, azido, carbonyl, carboxyl, CF 3 , —CH═CF 2 , —CH 2 CH═CF 2 , cyano, cycloalkyl, cycloalkylalkyl, ester, formyl, halogen, heteroaralkyl, heteroaryl, heterocyclyl, heterocyclylalkyl, hydroxyl, ketone, nitro, phosphate, phosphoryl, silyl, sulfamoyl, sulfate, sulfhydryl, sulfonamido, sulfonate, sulfonyl, sulfonylamino, sulfoxido, thiocarbonyl, thiocarboxylate, thioester, thioether, and thioformate on the ring to which it is attached; and wherein said compound inhibits a TRPV3-mediated current with an IC 50 of 10 micromolaror less.