Patent ID: 8642083

Claim:
A lag-time delayed release combination pharmaceutical composition for oral administration comprising (a) a delayed-release portion comprising a therapeutically effective amount of a release-controlling material and an angiotensin-II-receptor blocker selected from the group consisting of losartan, valsartan, irbesartan, candesartan, telmisartan, eprosartan, olmesartan, and pharmaceutically acceptable salts thereof; and (b) an immediate release portion comprising a therapeutically effective amount of an HMG-CoA reductase inhibitor selected from the group consisting of simvastatin, lovastatin, atorvastatin, pitavastatin, rosuvastatin, fluvastatin, pravastatin, pharmaceutically acceptable salts thereof and mixtures thereof, wherein more than 80% of the HMG-CoA reductase inhibitor is released within one hour, and less than 10% of the angiotensin-II-receptor blocker is released after up to two hours, when tested with a paddle dissolution method at 50 rpm in artificial gastric juice for two hours and artificial intestinal juice thereafter.