Patent ID: 8119808

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: R 1 is selected from the group consisting of hydrogen, alkyl, halo and CN; R 2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, acyl, halo, CF 3 , CN, nitro, phenyl, thienyl, pyridinyl, oxopyridinyl, oxopyrrolidinyl, oxopiperidinyl, imidazolyl, pyrazolyl and OR 11 , NR 12 R 12a , wherein phenyl, thienyl, pyridinyl, oxopyridinyl, oxopyrrolidinyl, oxopiperidinyl, imidazolyl and pyrazolyl may each be optionally substituted; R 3 is selected from the group consisting of hydrogen, alkyl, halo and CN; R 4 is selected from the group consisting of hydrogen, alkyl, halo and CN; R 5 is selected from the group consisting of alkyl, cycloalkyl, phenyl, thienyl, pyrazinyl, pyridinyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyranyl, thiazolyl and isothiazolyl, wherein alkyl, cycloalkyl, phenyl, thienyl, pyrazinyl, pyridinyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyranyl, thiazolyl and isothiazolyl may each optionally be substituted; R 6 and R 6a are each independently selected from the group consisting of hydrogen and alkyl; R 2 and R 7a are each independently selected from the group consisting of hydrogen and alkyl; R 8 is hydrogen; R 9 is selected from the group consisting of hydrogen and alkyl; R 10 is selected from the group consisting of alkyl, alkenyl, alkoxy, cycloalkyl, thienyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolidinonyl, furanyl, isooxazolyl, piperidinyl, morpholinyl, phenyl, pyridinyl, benzothiadiazolyl and NR 12 R 12a , wherein alkyl, alkenyl, alkoxy, cycloalkyl, thienyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolidinonyl, furanyl, isooxazolyl, piperidinyl, morpholinyl, phenyl, pyridinyl, benzothiadiazolyl may each optionally be substituted; R 11 is phenyl; R 12 and R 12a are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl and phenyl; or R 12 and R 12a taken together form morpholine, piperidine or pyrrolidine; X is selected from the group consisting of (CR 14 R 14a ) n , CO and S(O) 2 ; Y is selected from the group consisting of S(O) 2 , SO 2 N(R 15 ) and C(O)C(O); R 14 and R 14a are each hydrogen; R 15 is selected from the group consisting of hydrogen and alkyl; or R 15 and R 10 taken together can form morpholine, piperidine or oxazolidinone; n is an integer of 0, 1 or 2; and provided that when Y is S(O) 2 and R 5 is other than alkyl, R 10 is not optionally substituted phenyl.