Patent ID: 7022736

Claim:
A compound, or a pharmaceutically acceptable ester or salt thereof, of formula: wherein R 5 is selected from the following substituent groups: (1) an alkyl group having 1 to 12 carbon atoms, substituted by —CN and optionally interrupted by a group selected from —O—, —S—, —NR 3 —, —C(═O)—, —CO 2 —, —OCO—, —CONR 3 —, —NR 3 CONR 3 —, —SO 2 —, —NR 3 SO 2 —, and —SO 2 NR 3 —; where each R 3 independently is H or lower alkyl of 1 to 6 carbon atoms; (2) —OR 4 where R 4 is an aralkyl group having 3 to 16 carbon atoms optionally substituted with any one or more of groups: (a) —OH; (b) —SH; (c) -halogen, (d) —CO 2 H; (e) —CN; (f) —NO 2 ; (g) —NR 1 R 2 wherein each of R 1 and R 2 is selected from H and lower alkyl groups having 1 to 6 carbon atoms; (h) —SO 2 NR 1 R 2 where R 1 and R 2 are as defined above; (i) —CONR 1 R 2 , —NR 1 CO 2 H, or —NR 1 COCOOH where R 1 and R 2 are as defined above; (j) an alkyl (or alkenyl or alkynyl group) group having 1 to 12 carbon atoms, optionally substituted by any one or more of the groups (a)–(i) above and/or optionally interrupted by a group selected from —O—, —S—, —NR 3 —, —C(═O)—, —CO 2 —, —OCO—, —CONR 3 —, —NR 3 CONR 3 —, —SO 2 —, —NR 3 SO 2 —, and —SO 2 NR 3 —; where each R 3 independently is as defined above; and (3) —NHSO 2 R 4 * or —SO 2 NHR 4 *, where R 4 * is an aryl group having 2 to 10 carbon atoms optionally substituted with any one or more of groups (a) to (j) above; and wherein R 6 is independently selected from hydrogen and the substituent groups (a) to (j) as defined above.