Patent ID: 8889632

Claim:
A modified polypeptide of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: each R 1 and R 2 are independently H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, or heterocyclylalkyl; each R 3 is independently alkylene, alkenylene, alkynylene, or [R 4 —K—R 4 ′] n , each of which is substituted with 0-6 R 5 ; each R 4 and R 4 ′ are independently alkylene, alkenylene, or alkynylene; each R 5 is independently halo, alkyl, OR 6 , N(R 6 ) 2 , SR 6 , SOR 6 , SO 2 R 6 , CO 2 R 6 , R 6 , a fluorescent moiety, or a radioisotope; each K is independently O, S, SO, SO 2 , CO, CO 2 , CONR 6 , or each R 6 is independently H, alkyl, or a therapeutic agent; each n is independently an integer from 1-4; x is 6; each y is independently an integer from 1-15; each w is independently an integer from 3 to 15; z is an integer from 1-10; and each Xaa is independently an amino acid; wherein the modified polypeptide or the pharmaceutically acceptable salt thereof comprises at least 8 contiguous amino acids of Leu 1 Ser 2 Gln 3 Glu 4 Thr 5 Phe 6 Ser 7 Asp 8 Leu 9 Trp 10 Lys 11 Leu 12 Leu 13 Pro 14 Glu 15 Asn 16 (SEQ ID NO:2), wherein the side chains of Ser 7 and Pro 14 are replaced by the linking group R 3 , and none or up to 6 amino acids other than Phe 6 , Trp 10 and Leu 13 are independently replaced by any other amino acid.