Patent ID: 7255872

Claim:
A method of immobilization of a mediator molecule on an implant material, comprising: covalently binding an anchor molecule to a chemically activated surface of the implant material, wherein the anchor molecule has a functional group having sufficient reactivity to allow covalent binding of a chemical compound; binding an agarose spacer molecule to the anchor molecule, wherein the agarose spacer molecule has an additional functional group having sufficient reactivity for covalent binding of the mediator molecule; covalently immobilizing a mediator molecule on the implant material using the additional functional group; wherein the mediator molecule comprises a biomolecule that at least one of (a) reduces rejection of the implant material, and (b) promotes growing-in of the implant material; and wherein said implant material comprises at least one component selected from the group consisting of a metal, a metallic alloy, and a ceramic material.