Patent ID: 8604209

Claim:
A method of synthesizing a compound of the structure wherein R is H, R 1 a and R 1 b are independently selected from H and F, provided that at least one of R 1 a and R 1 b is F, Het is tetrazolyl optionally-substituted with methyl; comprising treating a compound having the structure wherein R 2 is selected from the group consisting of optionally substituted benzyl and optionally substituted C 1 -C 6 alkyl, with glycidyl ester in the presence of a strong base or an organolitihium salt under conditions to make wherein the optionally-substituted benzyl and the optionally-substituted C 1 -C 6 alkyl are independently unsubstituted or substituted with halogen or C 1 -C 4 alkyloxy.