Patent ID: 8501736

Claim:
A compound of the formula (I) wherein R 1 is H, (C 1 -C 6 )alkyl, R′, NH—(C 1 -C 6 )alkyl, NHR′, or N[(C 1 -C 6 )alkyl] 2 ; R 2 is H, halogen, or (C 1 -C 6 )alkyl; R 3 is H, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylene-R′, OH, O—R″ NH 2 , NHR″, NR″R″ or NH—C(O)—R″, R 4 is H, halogen, hydroxy, CN, (C 1 -C 6 )alkyl, R′, (C 1 -C 6 )alkylene-R′; R 5 is H, halogen, CN, NO 2 , (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, R′, (C 1 -C 6 )alkylene-(C 6 -C 10 )aryl, (C 2 -C 6 )alkenylene-(C 6 -C 10 )aryl, (C 1 -C 6 )alkylene-(C 5 -C 10 )heterocyclyl, CH(OH)—(C 1 -C 6 )alkyl, NH 2 , NH—R′, NH—SO 2 H, NH—SO 2 —(C 1 -C 6 )alkyl, NH—SO 2 —R′, NH—C(O)—(C 1 -C 6 )alkyl, NH—C(O)—R′, C(O)N[(C 1 -C 6 )alkyl] 2 , C(O)OH, or C(O)O—(C 1 -C 6 )alkyl; R 6 is H, R′, (C 1 -C 8 )alkyl, (C 1 -C 6 )alkylene-R′, (C 1 -C 6 )alkylene-O—(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylene-O—R′, (C 1 -C 6 )alkylene-CH[R′] 2 , (C 1 -C 6 )alkylene-C(O)—R′, (C 1 -C 6 )alkylene-C(O)NH 2 , (C 1 -C 6 )alkylene-C(O)NH—R′, or (C 1 -C 6 )alkylene-C(O)N[R′] 2 ; R 7 is H, halogen, CN, NO 2 , (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, R′, (C 2 -C 6 )alkenylene-(C 6 -C 10 )aryl, (C 1 -C 6 )alkylene-R′, CH(OH)—(C 1 -C 6 )alkyl, NH 2 , NH—R′, NH—SO 2 H, NH—SO 2 —(C 1 -C 6 )alkyl, NH—SO 2 —R′, SO 2 —NH 2 , SO 2 —NHR′, NH—C(O)—(C 1 -C 6 )alkyl, NH—C(O)—R′, C(O)N[(C 1 -C 6 )alkyl] 2 , C(O)OH, or C(O)O—(C 1 -C 6 )alkyl; R 8 is H, halogen, or (C 1 -C 6 )alkyl; n is 1, 2, 3 or 4; and L is O or O—(C 1 -C 6 )alkylene; R′ is (C 3 -C 8 )cycloalkyl, (C 5 -C 10 )heterocyclyl, or (C 6 -C 10 )aryl; R″ is (C 3 -C 8 )cycloalkyl, (C 5 -C 10 )heterocyclyl, (C 6 -C 10 )aryl, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylene-R′, (C 1 -C 6 )alkylene-O—(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylene-O—R′, or (C 1 -C 6 )alkylene-NR x R y ; and R x and R y are independently of each other (C 1 -C 6 )alkyl, (C 5 -C 10 )heterocyclyl, (C 6 -C 10 )aryl, (C 1 -C 4 )alkylene-(C 5 -C 10 )heterocyclyl, (C 1 -C 4 )alkylene-(C 6 -C 10 )aryl, (C 1 -C 4 )alkylene-NH(C 1 -C 6 )alkyl, (C 1 -C 4 )alkylene-N[(C 1 -C 6 )alkyl] 2 , (C 1 -C 4 )alkylene-N[(C 6 -C 10 )aryl] 2 , or (C 1 -C 4 )alkylene-N[(C 5 -C 10 )heterocyclyl] 2 ; and wherein in residues R 4 , R 5 , R 7 and R 8 one alkyl or alkylene hydrogen atom can be optionally substituted by OH, OCH 3 , COOH, COOCH 3 , NH 2 , NHCH 3 , N(CH 3 ) 2 , CONH 2 , CONHCH 3 or CON(CH 3 ) 2 , and in any residue one or more alkyl or alkylene hydrogen atoms can optionally be substituted by F; or a pharmaceutically acceptable salt thereof, a physiologically functional derivative thereof, or a pharmaceutically acceptable salt and physiologically functional derivative thereof.