Patent ID: 8921368

Claim:
A compound of Formula (II): or stereoisomers or salts thereof; wherein: R 1 is C 3-6 cycloalkyl or adamantanyl, each substituted with 1, 2, 3, or 4 substituents independently selected from F, Cl, —OH, —CN, C 1-4 alkyl, ═O, —O(C 1-6 alkyl), —NH 2 , —NH(C 1-4 alkyl), —NH(benzyl), —N(C 1-4 alkyl) 2 , —NHC(O)(C 1-4 alkyl), —NHC(O)O(C 1-4 alkyl), —NHS(O) 2 (C 1-4 alkyl), —NHC(O)NH(C 1-4 alkyl), —NHC(O)NH(C 1-4 alkyl), —NHC(O)NH(phenyl), —C(O)NH 2 , and/or —CH 2 NHC(O)CH(OH)(C 1-4 alkyl); R 2 is -L-R x or R y ; L is —NHC(O)—, —NHS(O) 2 —, —NHC(O)NH—, —NHC(O)O—, or —C(O)NH—; R x is C 1-6 alkyl; benzyl; or phenyl substituted with zero or 1 substituent selected from F, Cl, and —O(Cl 1-4 alkyl); and R y is: a) phenyl substituted with zero, 1, or 2 substituents independently selected from F, Cl, C 1-6 alkyl, —NH 2 , —N(C 1-4 alkyl) 2 , —O(C 1-4 alkyl), C 1-6 hydroxyalkyl, C 1-4 aminoalkyl, —CN, —C(O)(C 1-4 alkyl), —CH 2 NHC(O)(C 1-4 alkyl), —C(O)OH, —C(O)O(C 1-4 alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl), —C(O)N(C 1-4 alkyl) 2 , —C(O)NH(C 3-6 cycloalkyl), —C(O)NH(C 3-6 cycloalkyl), —S(O) 2 (C 1-4 alkyl), —NHC(O)(C 1-4 alkyl), —NHC(O)O(C 1-4 alkyl), —NHC(O)CH 2 CH 2 O(C 1-4 alkyl), —NHS(O) 2 (C 1-4 alkyl), —O(C 1-4 alkyl), —O(C 1-4 fluoroalkyl), —S(O) 2 NH 2 , —C(O)(morpholinyl), —CH 2 (morpholinyl), phenyl, pyrazolyl, tetrazolyl, and/or morpholinyl; b) azetidinonyl, pyrrolidinyl, pyrrolidinonyl, 1H-pyrrol-2(5H)-onyl, 1H-pyrrol-2(5H)-onyl, oxazolidinonyl, piperazinyl, piperazinonyl, morpholinyl, morpholinonyl, 1H-pyrrol-2(5H)-onyl, or imidazolidinonyl, each substituted with zero, 1, or 2 substituents independently selected from —OH, C 1-4 alkyl, —O(C 1-4 alkyl), —C(O)(C 1-4 alkyl), phenyl, and/or benzyl; or c) pyrrolyl, pyrazolyl, thiazolyl, isoxazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyridinyl, pyridinonyl, pyrimidinyl, pyrazinyl, dihydropyridinyl, indolyl, dihydroisoquinolinonyl, imidazo[1,2-a]pyridinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, indazolyl, benzothiazolyl, isoquinolinyl, quinolinyl, or quinoxalinyl, each substituted with zero, 1, or 2 substituents independently selected from F, Cl, C 1-4 alkyl, C 1-3 fluoroalkyl, —NH 2 , —CN, C 1-4 hydroxyalkyl, —O(C 1-4 alkyl), —O(phenyl), —O(benzyl), —C(O)OH, —C(O)O(C 1-4 alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl), —NHC(O)(C 1-4 alkyl), phenyl, benzyl, fluorophenyl, chlorophenyl, —NH(C 3-6 cycloalkyl), —NH(tetrahydropyranyl), —NH(C 1-6 alkyl), —NH(CH 2 —C 3-6 cycloalkyl), —NH(CH(CH 3 )—C 3-6 cycloalkyl), and/or —NH(tetrahydropyranyl).