Patent ID: 6908936

Claim:
A compound having the Formula II or Formula III, or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are independently H, alkyl, alkyl substituted with 1 to 6 halogen atoms, NO 2 , CN, halogen, COR′, COOR′, and CONHR′, R′ is H or alkyl, and said alkyl contains 1 to 6 carbon atoms; X is straight, branched or cyclic alkylene group optionally containing one unsaturated double or triple bond, wherein said group has 2 to 12 carbon atoms; Y is selected from: (a) R 9 , —NHCOR 9 , ═N—O—R 9 ; —CONHR 9 , —COOR 9 , —CO—R 9 , —OR 9 , wherein R 9 and R 10 are independently H, straight, branched or cyclic alkyl containing 1 to 7 carbon atoms; or R 9 taken together with R 10 forms a cyclic alkyl group having 3 to 7 carbon atoms; (b) —N 3 , —CN, halogen, —NO 2 , —NR″SO 2 R′″, —SR″, —SOR″, —SO 2 R″, —SO 2 NR″, wherein said R″ and R′″ are independently hydrogen, C 1 -C 6 alkyl, phenyl, or phenyl substituted with from 1 to 6 halogen atoms or C 1 -C 6 alkyl groups; (c) phenyl optionally substituted with from 1 to 6 halogen atoms or C 1 -C 6 alkyl groups; or X and Y taken together is selected from —CH 2 Ph, —CH 2 COPh or —CH 2 CHOHPh; wherein n is 1 or 2, R is C 1 -C 4 alkyl and Ph is phenyl; Z is —(CR 12 R 13 ) n —, wherein n is 1-4, and R 12 and R 13 are independently H, straight, branched or cyclic C 1 -C 6 alkyl; provided when R 2 is H, Cl, CF 3 , CH 3 CO or NO 2 ; R 1 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not at the same time H; Z is not (CH 2 ) n , where n is 1-3; X is not (CH 2 )z, where z is 2 or 3; Y is not N(CH 3 ) 2 or N(C 2 H 5 ) 2 further provided when X and Y taken together is —CH 2 CH(CH 3 ) 2 , then Z is not CH 2 and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not each H at the same time.