Patent ID: 7452551

Claim:
A targeted vesicle composition for therapeutic or diagnostic use in vivo comprising, in an aqueous carrier, gas filled liposomes comprising a phosphatidylcholine selected from the group consisting of dioleoylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine and distearoylphosphatidylcholine, wherein said liposomes further comprise a compound having the formula wherein: X 1 is a moiety selected from the group consisting of C(═X 3 ), and C(═X 3 )—N(R 8 ); X 3 is O or S; R 1 acyl having from 16 to 23 carbons; R 2 is hydrogen or lower alkyl; R 3 is a moiety having the structure (CH 2 ) n , wherein n is an integer having the value between 1 and 10; R 4 is acyl having from 16 to 23 carbons; R 5 is hydrogen or lower alkyl; R 7 is (CH 2 )—(CH 2 ) or a direct bond; R 8 is hydrogen or lower alkyl; P is PEG; and T is a targeting ligand comprising a peptide having the sequence CRGDC, wherein the two cysteines are linked together via a disulfide linkage.