Patent ID: 7072771

Claim:
A method for identifying agents that selectively inactivate poly(ADP-ribose) polymerase-1 (PARP-1), comprising the steps of: (a) contacting a test compound with a polypeptide comprising the PARP-1 src-homology domain 3 (SH-3 domain), the PARP-1 SH-3 ligand domain, or both domains; (b) determining whether the test compound binds to the SH-3 domain or PARP-1 SH-3 ligand domain; (c) assaying any test compound that binds to the SH-3 domain or PARP-1 SH-3 ligand domain to determine whether the compound inactivates or prevents the activation of PARP-1; and (d) identifying the test compound as a compound that selectively inactivates or prevents the activation of PARP-1.