Patent ID: 8084058

Claim:
A pharmaceutical dosage form comprising: (a) a controlled release core comprising metformin hydrochloride and at least one pharmaceutically acceptable excipient; and (b) an immediate release pioglitazone layer applied to the controlled release metformin core wherein the immediate release pioglitazone layer comprises: (i) pioglitazone hydrochloride; (ii) a binder; (iii) about 1 to about 15% based upon the total weight of the pioglitazone layer of a poloxamer; and (iv) about 5 to about 30% based upon the total weight of the pioglitazone layer of sodium starch glycolate; and wherein not less than 95% of the pioglitazone is released from the dosage form within 30 minutes when tested according to the United States Pharmacopeia (USP) 26, with Apparatus 1 at 100 rpm, 37° C. and 900 ml of 0.3 M KCl—HCl Buffer, pH 2.0; and wherein the dosage form exhibits a C max for the pioglitazone that is at least 130% of the C max for an immediate release pioglitazone tablet containing the same amount of pioglitazone as present in the immediate release pioglitazone layer, and an AUC for the pioglitazone that is at least 115% of the AUC for the immediate release pioglitazone tablet.