Patent ID: 8268352

Claim:
A modified release dosage form comprising of a high solubility active ingredient prepared by using dual retard technique to control the release of the high solubility active ingredient, wherein the said dual retard technique is a combination of matrix formulation and reservoir formulation said dosage form consists of a) micro matrix particles which contain a high solubility active ingredient and one or more hydrophobic release controlling agents, and b) a coating of one or more hydrophobic release controlling agents on said micro matrix particles to form a double barrier to control the diffusion of the high solubility active ingredient, wherein the hydrophobic release controlling agents are selected from the group consisting of poly(ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride) 1:2:0.1; poly(ethyl acrylate, methyl methacrylate, trimethylamonioethyl methacrylate chloride) 1:2:0.2 and poly(ethyl acrylate, methyl methacrylate) 1:1, polyvinyl acetate dispersion, ethylcellulose, cellulose acetate, lower molecular weight cellulose propionate, medium molecular weight cellulose propionate, higher molecular weight cellulose proprionate, cellulose acetate propionate, cellulose acetate butyrate, cellulose acetate phthalate, cellulose triacetate, poly(methyl methacrylate), poly(ethyl methacrylate), poly(butyl methacrylate), poly(isobutyl methacrylate), poly (hexyl methacrylate), poly(isodecyl methacrylate), poly (lauryl methacrylate), poly(phenyl methacrylate), poly (methyl acrylate), poly (isopropyl acrylate), poly (isobutyl acrylate), poly (octadecyl acrylate), beeswax, carnauba wax, microcrystalline wax, and ozokerite; cetostearyl alcohol, stearyl alcohol; cetyl alcohol and myristyl alcohol; glyceryl monostearate; glycerol monooleate, acetylated monoglycerides, tristearin, tripalmitin, cetyl esters wax, glyceryl palmitostearate, glyceryl behenate and hydrogenated castor oil, wherein the active ingredient can be less than or equal to 1500 mg.