Patent ID: 7304052

Claim:
A compound of formula (I) their N-oxides, addition salts, quaternary amines and stereochemically isomeric forms thereof, wherein wherein R 2 is hydrogen, hydroxy, C 1-4 alkyl, or C 1-4 alkyloxy, and when R 2 is hydroxy or C 1-4 alkyloxy then said R 2 is bonded at a different position than the α-position of the ring nitrogen, or when R 2 is hydroxy then said R 2 is bonded at a different position than a vinylic position of radical (a-2), (a-3), (a-4), (a-5), (a-6), (a-8), (a-9), (a-10), (a-11), or (a-12); -a 1 =a 2 -a 3 =a 4 - represents a bivalent radical of formula —CH═CH—CH═CH— (b-1), —N═CH—CH═CH— (b-2), —CH═N—CH═CH— (b-3), —CH═CH—N═CH— (b-4), —CH═CH—CH═N— (b-5), —CH═CH—N═N— (b-6), —N═CH—CH═N— (b-7), —N═CH—N═CH— (b-8), —N═N—CH═CH— (b-9), —CH═N—CH═N— (b-10), or —CH═N—N═CH— (b-11), wherein each hydrogen atom in the radicals (b-1) to (b-11) may optionally be replaced by halo, C 1-6 alkyl, nitro, amino, hydroxy, C 1-6 alkyloxy, polyhaloC 1-6 alkyl, carboxyl, aminoC 1-6 alkyl, hydroxyC 1-6 alkyl, mono- or di(C 1-4 alkyl)aminoC 1-6 alkyl, C 1-6 alkyloxycarbonyl; or wherein two hydrogen atoms on adjacent carbon atoms in the radicals (b-1) to (b-11) may optionally be replaced by —(CH 2 ) 4 —; R 1 is hydrogen, C 1-6 alkyl, aryl 1 , C 1-6 alkyl substituted with aryl 1 , C 1-4 alkyloxycarbonyl, aryl 1 carbonyl, aryl 1 C 1-6 alkylcarbonyl, aryl 1 carbonylC 1-6 alkyl, aryl 1 oxycarbonyl, aryl 1 C 1-4 alkyloxycarbonyl, C 1-4 alkylcarbonyl, trifluoromethyl, trifluoromethylcarbonyl, C 1-6 alkylsulfonyl, aryl 1 sulfonyl, methanesulfonyl, benzenesulfonyl, trifluoromethanesulfonyl, or dimethylsulfamoyl; X represents O, S or NR 3 , wherein R 3 is hydrogen; C 1-6 alkyl; methanesulfonyl; benzenesulfonyl; trifluoromethanesulfonyl; dimethylsulfamoyl; aryl 2 carbonylC 1-4 alkyl; C 1-4 alkyloxycarbonyl; C 1-4 alkyl substituted with aryl 2 and optionally with hydroxy; or C 1-4 alkylcarbonylC 1-4 alkyl substituted with aryl 2 ; aryl 1 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, nitro, amino, cyano, and trifluoromethyl; pyridinyl; pyridinyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C 1-6 alkyl, amino, and diC 1-4 alkylamino; naphthyl; quinolinyl; 1,3-benzodioxolyl; furanyl; thienyl; or benzofuranyl; and aryl 2 is phenyl, or phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, nitro, amino, cyano, and trifluoromethyl.