Patent ID: 7678335

Claim:
An apparatus for simultaneous multiple and high-throughput synthesis of peptides and other molecules based on the solid-phase synthesis technique comprising: an automated synthesizer comprising a gripper arm that can be moved along x, y, and z axes and is disposed above a working surface on a base of said automated synthesizer, a synthesizer plate located on said working surface of the apparatus, a plurality of separate synthesizer pins ( 11 ), each pin including a reagent reservoir ( 20 ) that contains a given synthetic unit 50 , a holder ( 4 ) that holds said plurality of synthesizer pins upon said working surface, a plurality of reaction chambers ( 9 ) disposed on said synthesizer plate, the reaction chambers each having an opening at its top side, and a permeable material ( 25 ) comprising a frit and configured to close said opening, and further including a porous membrane ( 28 ) disposed at a bottom side of each of said reaction chambers, a sample coupon ( 27 ) that is disposed underneath the synthesizer plate to collect a dissolved sample after separation, and a valve block for collecting and discharging rinsing solutions, wherein the valve block is disposed upon said working surface between said synthesizer plate and said sample coupon.