Patent ID: 8318904

Claim:
A liquid, aqueous, and pharmaceutically acceptable composition comprising (i) at least 0.01 mg/mL of a Factor VII polypeptide; (ii) a buffering agent suitable for keeping pH of the composition in the range of about 4 to about 9; and (iii) a stabilizing composition comprising a benzamidine compound comprising a motif comprising—substituted benzene ring—C(═N—Z 1 —R 1 )—NH—Z 2 —R 2 , wherein substituted benzene ring denotes a benzene ring comprising one substitution, and Z 1 and Z 2 independently are selected from the group consisting of —O—, —S—, —NR H — and a single bond, where R H is selected from the group consisting of hydrogen, C 1-4 -alkyl, aryl and arylmethyl, and R 1 and R 2 independently are selected from the group consisting of hydrogen, optionally substituted C 1-6 -alkyl, optionally substituted C 2-6 -alkenyl, optionally substituted aryl, optionally substituted heterocyclyl, —C═N—Z 1 —R 1 forms part of a heterocyclic ring, —C—NH—Z 2 —R 2 forms part of a heterocyclic ring, or —C(═N—Z 1 —R 1 )—NH—Z 2 —R 2 forms a hetercyclic ring wherein —Z 1 —R 1 —R 2 —Z 2 — is a biradical.