Patent ID: 7683075

Claim:
A compound of formula I wherein R 1 and R 2 , independently, are hydrogen, (C 1-4 )alkyl, halogen, hydroxy, (C 1-4 )alkoxy, di(C 1-4 )alkylamino, (C 1-4 )alkylthio, cyano or trifluoromethyl, R 3 is hydrogen or (C 1-4 )alkyl and n is 1 or 2, in free base or acid addition salt form, wherein the compound is selected from the group consisting of: isoquinoline-3-carboxylic acid{(S)-1-azabicyclo[2.2.2]oct-3-yl}-amide, isoquinoline-3-carboxylic acid{(R)-1-azabicyclo[2.2.2]oct-3-yl}-amide, 6-fluoro-isoquinoline-3-carboxylic acid{(R)azabicyclo[2.2.2]oct-3-yl}-amide, 8-fluoro-isoquinoline-3-carboxylic acid{(R)-1-azabicyclo[2.2.2]oct-3-yl}amide, and 8-fluoro-isoquinoline-3-carboxylic acid{(S)-1-azabicyclo[2.2.2]oct-3-yl}-amide.