Patent ID: 7078425

Claim:
A compound of the formula and pharmaceutically acceptable salts and prodrugs thereof, wherein is an optional bond; R 1 and R 2 are independently selected from hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, alkoxyalkyl, hydroxyalkyl, lower alkenyl, amino, mono- or dialkylamino, cyano, nitro, trifluromethyl, —CON( 6 ) 2 or —COOR 6 ; R 3 and R 4 are independently selected from hydrogen, halogen, lower alkyl, lower alkenyl, cycloalkyl, cyano, —CON(R 6 ) 2 or —COOR 6 ; A is selected from lower alkyl, lower alkenyl, lower alkynyl, —C(O)R 7 , —S(O) 2 R 7 , —C(O)NHR 7 , —CO 2 R 7 , —(CH 2 ) n S(O) q R 7 , —(CH 2 ) p C(O)R 7 , —(CH 2 ) p C(O)NHR 7 , —(CH 2 ) p CO 2 R 7 , (CH 2 ) n OR 7 , or aryl, heteroaryl, arylalkyl or heteroarylalkyl, where the ring portion of each is optionally substituted with one, two or three groups independently selected from halogen, lower alkyl, hydroxy, amino, mono- or dialkylamino, trifluoromethyl, —C(O)R 8 , —COOR 8 , —C(O)NHR 8 or —OR 8 ; B is selected from hydrogen, lower alkyl, lower alkenyl, lower alkynyl, —(CH 2 ) n S(O) q R 7 , —(CH 2 ) p C(O)R 7 , —(CH 2 ) p C(O)NHR 7 , —(CH 2 ) p CO 2 R 7 , (CH 2 ) n OR 7 , or aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl or heteroarylalkynyl, where the ring portion of each is optionally substituted with one, two or three groups independently selected from halogen, lower alkyl, hydroxy, amino, mono- or dialkylamino, trifluoromethyl, —C(O)R 8 , —COOR 8 , —C(O)NHR 8 or —OR 8 ; n is 2–4; p is 1–2; q is 0–2; R 6 is selected from hydrogen, lower alkyl, or lower alkenyl; R 7 is selected from aryl, heteroaryl, arylalkyl, or heteroarylalkyl, where the ring portion of each is optionally substituted with one, two or three groups independently selected from halogen, lower alkyl, hydroxy, amino, mono- or dialkylamino, trifluoromethyl, —C(O)R 8 , —COOR 8 , —C(O)NHR 8 or —OR 8 ; R 8 is independently selected from hydrogen, or lower alkyl, aryl or heteroaryl optionally substituted with one, two or three groups independently selected from lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, or trifluoromethyl; X and Y are nitrogen or CR 10 ; and R 10 is selected from hydrogen, hydroxy, halogen or amino.