Patent ID: 7238498

Claim:
An isolated nucleic acid molecule selected from: (a) nucleic acid molecule comprising a nucleotide sequence set forth as SEQ ID NO: 2; (b) nucleic acid molecule comprising a nucleotide sequence capable of hybridizing, under stringent hybridization conditions comprising 0.5 M NaHPO 4 , 7% sodium dodecylsulfate (SDS), 1 mM EDTA at 65° C., to a nucleotide sequence complementary to the polypeptide coding region of a nucleic acid molecule as defined in (a) and wherein the nucleic acid molecule codes for a biologically active mammalian Inhibitory Per-Arnt-Sim (IPAS) polypeptide that inhibits angiogenesis and/or tumor progression; and (c) nucleic acid molecule comprising a nucleic acid sequence which is degenerate as a result of the genetic code to a nucleotide sequence as defined in (a) or (b) and wherein the nucleic acid molecule codes for a biologically active mammalian IPAS polypeptide.