Patent ID: 7563761

Claim:
A conjugate for mediating a cell nucleus-specific transport of a peptide nucleic acid (PNA) which hybridizes to DNA of HIV and inhibits the transcription of the DNA of a transcribable HIV gene or a HIV gene involved in the regulation of gene expression or a part thereof, wherein the conjugate comprises the following components: a) a transport peptide or protein which can pass through the plasma cell membrane, b) an address protein or peptide for the import into the cell nucleus which contains a nucleus-recognition signal, and c) a peptide nucleic acid (PNA) comprising a sequence selected from SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 22, TTATTTCCTCTTTTGTTG (SEQ ID NO: 4), ATTAC*TAC*GTC*TC*TC*C*GTT (SEQ ID NO: 5), TATC *GGTTTTTAAC*GTC*C*C* (SEQ ID NO: 6), and, TC*C*TTTTC*C*C*C*GAC*AAC*C*TTTAC* (SEQ ID NO: 7), wherein C* is pseudoisocytosine, wherein the PNA is to be transported and hybridizes to DNA of HIV and inhibits the transcription thereof, wherein said DNA is selected from the group consisting of polypurine tract, central DNA flap, Nef, NCp7 and LTR region.