Patent ID: 8765910

Claim:
A process for preparing a C-terminally amidated peptide of the formula (AA)-X—NH 2 wherein (AA) is a peptide that comprises an amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:4 and wherein X is lysine or arginine; the process comprising reacting a peptide having the amino acid sequence of SEQ ID NO:7 with (i) H-Arg-NH 2 in a 585:1 molar ratio in the presence of an enzyme having the biological activity of trypsin to produce the C-terminally amidated peptide of SEQ ID NO:4, or (ii) H-Lys-NH 2 in a 144:1 molar ratio in the presence of an enzyme having the biological activity of trypsin to produce the C-terminally amidated peptide of SEQ ID NO:1, and the resulting C-terminally amidated peptide is subjected to protein chemical purification.