Patent ID: 7893034

Claim:
A method for inhibiting the expression of an oncogene containing a let-7 complementary site (LCS) selected from the group consisting of NRAS, KRAS, HRAS, MYC, MYCL1, MYCN, BCL2, BCL2L1, BCL2L2, TERT, VEGF, EGF, EGFR, ERBB3, GRB2, RAF1, ARAF, MAP2K2, MAPK1, MAPK3, MET, KIT, TP73L(AIX), CCND1, CDK4, MDM2, FES, FURIN, INSL3, CSFIR, MYBL2, MYB, PIK3CD, PIK3C2B, PIK3CG, PIK3R5, AKT1, HLIN-41, VDR, PXR, FOXA1, FOXA2, ASH1L, ARID1B, GR, GLI2,14-3-3zeta, MO25, SMG1, FRAP1, PER2 and AKT3 comprising providing an effective amount of a composition comprising a let-7 miRNA and a suitable pharmaceutical carrier to bind to and inhibit expression of an mRNA encoded by the oncogene or to increase expression of a let-7 miRNA that binds to and inhibits expression of an mRNA encoded by the oncogene, in a cell of an organism.