Patent ID: 7747392

Claim:
A method of constructing a physiogenomics model suitable for predicting a human individual's response to an environmental stimulus comprising: (a) selecting a plurality of genetic markers based on an analysis of a fraction of the human genome; (b) exposing each subject of a study human population to the environmental stimulus and recording physiological response phenotypes for the study human population to the environmental stimulus; (c) using principal component analysis and identifying significant covariates among demographic data and clinical data for the study human population to the physiological response phenotypes for the study human population from (b); (d) performing for a genotype for each subject of the study human population from (b) and the physiological response phenotypes for the study human population from (b) an unadjusted association test, and identifying a subset of selected markers associated with the response to the environmental stimulus from the plurality of genetic markers; (e) using permutation testing on the subset of selected markers from (d) to obtain an adjusted probability value and choosing model building markers from the subset of selected markers; (f) identifying from the association testing in step (e) one or more markers from the plurality of genetic markers not associated with the study human population's physiological response to the environmental stimulus in order to serve as a physiogenomic control; (g) constructing the physiogenomic model from the significant covariates from (c), the model building markers from (e), and the physiogenomic control from (f) by linear regression analysis and model parameterization; and (h) presenting a display of the physiogenomic model to a user, wherein the physiogenomics model is suitable for predicting the human individual's response to the environmental stimulus.