Patent ID: 7943628

Claim:
A compound of Formula (I): or a pharmaceutically or veterinarily acceptable salt thereof, wherein: R 1 is C 3-7 cycloalkyl-C 0-6 alkyl- optionally substituted with methyl R 3 and R 2 together with the nitrogen atom to which they are bound form a 5 membered non-aromatic heterocyclic group, said group being optionally substituted by one or more substituents independently selected from C 1-6 alkyl, NR 6 R 7 , (CH 2 ) a C 3-7 cycloalkyl, alkoxyalkyl containing 2 to 8 carbon atoms, (CH 2 ) b het 1 , (CH 2 ) c CF 3 , (CH 2 ) y OCF 3 , (CH 2 ) d aryl and C 1-6 hydroxyalkyl, provided that the ring system is substituted by a group which contains at least one nitrogen atom; R 4 is H; R 5 is NR 11 R 12 ; R 6 and R 7 are each independently selected from H, C 1-6 alkyl and (CH 2 ) j C 3-7 cycloalkyl; or R 6 and R 7 , together with the nitrogen atom to which they are bound, form a 4, 5 or 6 membered heterocyclic group; R 8 is H or C 1-3 alkyl; R 11 and R 12 are each independently selected from H, C 1-6 alkyl and (CH 2 ) I C 3-7 cycloalkyl; a, b, c, d, j, and l are each independently selected from 0, 1, 2 and 3; z is selected from 1, 2 and 3; aryl is phenyl, naphthyl, anthracyl or phenanthryl, each optionally substituted by one or more groups independently selected from C 1-8 alkyl, C 1-8 alkoxy, OH, halo, CF 3 , CHF 2 , OCF 3 , OCHF 2 , SCF 3 , hydroxy-C 1-6 alkyl, C 1-4 alkoxy-C 1-6 alkyl, C 1-4 alkyl-S—C 1-4 alkyl, aryl 1 , het 1 , Oaryl 1 , Ohet 1 , Saryl 1 , Shet 1 , CF 2 CF 3 , CH 2 CF 3 , CF 2 CH 3 , C(O)NR 13 R 14 , C 3-8 cycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl, C 3-7 cycloalkyl-C 1-4 alkoxy, C 3-7 cycloalkyl-O—C 1-4 alkyl, C 3-7 cycloalkyl-C 1-4 alkoxy-C 1-4 alkyl, OC 3-7 cycloalkyl and SC 3-7 cycloalkyl, wherein the aryl 1 and het 1 groups are optionally substituted by at least one group selected from C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkoxy, OC 3-7 cycloalkyl, halo, CN, OH, CF 3 , CHF 2 , OCF 3 , OCHF 2 , hydroxyC 1-6 alkyl, C 1-4 alkoxy-C 1-4 alkyl, SC 1-6 alkyl and SCF 3 ; aryl 1 is phenyl, naphthyl, anthracyl or phenanthryl; and het 1 is an aromatic or non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 4-, 5- or 6- membered carbocyclic group or a second 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom.