Patent ID: 8426557

Claim:
Insulin-like growth factor 1 receptor (IGF-1 R) binding polypeptide, comprising an insulin-like growth factor 1 receptor binding motif, which motif consists of an amino acid sequence selected from: i) EX 2 X 3 X 4 AX 6 X 7 EIX 10 X 11 LPNLX 16 X 17 X 18 QX 20 X 21 AFIX 25 SLX 28 D (SEQ ID NO:398), wherein, independently of each other, X 2 is selected from G, P and K; X 3 is selected from F and Y; X 4 is selected from Y and F; X 6 is selected from A, L, S and G; X 7 is selected from I, L, M and V; X 10 is selected from I, L and V; X 11 is selected from T, A, S, G, L, Q, I and V; X 16 is selected from N and T; X 17 is selected from S, Q, H, R, N, K, P, A, D, E, G and T; X 18 is selected from S, Q, H, R, N, K, D, P, T and G; X 20 is selected from S, Q, H, R and W; X 21 is selected from T, G, R, A, N, D, Q, E, K and S; X 25 is selected from T, G, R, A, N, D, Q, E, K, H and S; and X 28 is selected from E, N, G, S, A, T, K, P, Q and D; and ii) an amino acid sequence which has at least 85% identity to the sequence defined in i).