Patent ID: 8410260

Claim:
A cosmetic/pharmaceutical composition comprising at least one double-stranded RNA oligonucleotide having a sense strand consisting of a sequence selected from the group consisting of SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, and 47, and a complementary anti-sense strand together with a population of cationic particulates less than or equal to 1 μm in size, and having a zeta potential ranging from 10 to 80 mV, wherein said population of cationic particulates comprises surfactant micelles, liposomes of nonionic and cationic surfactants, niosomes, oleosomes, particles of nanoemulsions, nanocapsules, organic particles or inorganic particles, and wherein said double-stranded oligonucleotide has blunt ends.