Patent ID: 7301014

Claim:
An isolated nucleic acid fragment encoding an estrogen receptor variant polypeptide selected from the group consisting of: (a) an isolated nucleic acid fragment encoding SEQ ID NO:1; (b) an isolated nucleic acid fragment encoding an amino acid sequence having at least 95% identity with the SEQ ID NO:1, wherein the amino acid sequence has dominant-negative estrogen receptor activity; (c) an isolated nucleic acid molecule that hybridizes with the isolated nucleic acid fragment of (a) under hybridization conditions of 6×SSC (1M NaCl), 45% to 50% formamide, 1% SDS at 37° C., and a wash in 0.5× to 1×SSC at 55° C. to 60° C., wherein the complement of the isolated nucleic acid fragment encodes an amino acid sequence that has dominant-negative estrogen receptor activity; and (d) an isolated nucleic acid fragment that is complementary to (a), (b) or (c).