Patent ID: 7592461

Claim:
A compound having the formula or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein: W is CR 22 or N; R 1 and R 2 are independently hydrogen, halogen, cyano, nitro, NH 2 , C 1-6 alkyl, CF 3 , —(CH 2 ) 0-3 OH, —CH(OH)C 1-6 alkyl, CH(OH)C 1-6 aryl, CHO, C 2-4 alkenyl, C 2-4 alkynyl, —O(C 1-6 alkyl), —OC(O)O(C 1-6 alkyl), —OC(O)NH 0-1 (C 1-6 alkyl) 2-0 , —OC(O)(C 1-6 alkyl), —CO 2 H, —C(O)C 1-6 alkyl, —C(O)NH 0-2 (C 1-6 alkyl) 2-0 , —(CH 2 ) 0-3 NH 0-2 (C 1-6 alkyl) 2-0 , —NHC(O)C 1-6 alkyl, —NHS(O) 2 C 1-6 alkyl, —N(S(O) 2 C 1-6 alkyl) 2 , —NHC(O)OC 1-6 alkyl, phenoxy, benzyloxy, phenyl acetylenyl, trimethylsilyl acetylenyl, C 3-6 cycloalkyl, a five- to six membered heterocyclo containing at least one N atom, or a five- to six membered heteroaryl containing at least one N atom; R 7 is C 1-4 alkyl; R 8 and R 9 are independently selected from (i) hydrogen and C 1-6 alkyl; and (ii) phenyl, benzyl, a five-membered heterocyclo, and a five-membered heteroaryl, each ring optionally substituted with one to two groups selected from hydroxy, cyano, halogen, methoxy, and C 1-6 alkyl; and R 21 and R 22 are independently (i) hydrogen, methyl, ethyl, or CF 3 ; (ii) substituted methylene (methylene substituted by optionally substituted phenyl, particularly 4-((4-pyridinyl)phenyl)methyl), or 4-((4-(methyloxy)phenyl)methyl)); or (iii) napthyl or phenyl, each of which is optionally substituted by halogen, or —OC 1-4 alkyl; or CONH (optionally substituted phenyl), particularly 4-halogen (particularly fluoro)-1-naphthalenyl, or 3-(((3-chloro-4-(methyloxy)phenyl)amino)carbonyl)phenyl; wherein cycloalkyl, aryl, heteroaryl or heterocyclo, used alone or in combination, are substituted or unsubstituted.