Patent ID: 7405307

Claim:
A compound of formula (I) the N-oxides, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein p 1 , p 2 and p 3 are integers each independently from 1 to 3; each R 1 is independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, hydroxy, mercapto, cyano, nitro, C 1-4 alkylthio, polyhaloC 1-6 alkyl, amino, C 1-4 alkylamino and di(C 1-4 alkyl)amino; each R 2 is independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, and trifluoromethyl; R 3 is hydrogen or C 1-4 alkyl; each R 4 is independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkyloxy, halo, and trifluoromethyl; Z is a bivalent radical of formula wherein m and m′ are integers from 1 to 3; R 5 is hydrogen, C 1-6 alkyl or aryl; X 1 is CH, N or an sp 2 hybridized carbon atom; A represents a bond, or C 1-6 alkanediyl optionally substituted with one or two groups selected from the group consisting of aryl, heteroaryl and C 3-10 cycloalkyl; B represents hydrogen; C 1-10 alkyl; or aryl or heteroaryl each optionally substituted with a group selected from halo, cyano, nitro, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkoxycarbonyl, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl; heteroarylC 1-10 alkyl; C 3-10 cycloalkyl; polyhaloC 1-6 alkyl; C 3-6 alkenyl; C 3-6 alkynyl; NR 7 R 8 ; or OR 9 ; wherein R 7 and R 8 each independently represent hydrogen; C 1-10 alkyl; or aryl or heteroaryl each optionally substituted with a group selected from halo, cyano, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl; heteroarylC 1-10 alkyl; C 3-10 cycloalkyl; C 7-10 polycycloalkyl; polyhaloC 1-6 alkyl; C 3-8 alkenyl; C 3-8 alkynyl; fused benzo-C 5-8 cycloalkyl; or R 7 and R 8 taken together with the nitrogen atom to which they are attached form a saturated heterocyclic radical having from 4 to 8 carbon atoms; and wherein R 9 represents C 1-10 alkyl; or aryl or heteroaryl each optionally substituted with a group selected from halo, cyano, nitro, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl; heteroarylC 1-10 alkyl; C 3-10 cycloalkyl; C 7-10 polycycloalkyl; polyhaloC 1-6 alkyl; C 3-8 alkenyl; C 3-8 alkynyl; or fused benzoC 5-8 cycloalkyl.