Patent ID: 7966056

Claim:
A method of magnetic resonance (MR) imaging to identify diseased areas comprising areas suffering from myocardial ischemia, said method comprising a) administering to a human or non-human animal body a contrast agent comprising (i) at least one complex of the formula Mn m HPTA Z o , wherein m is 1 or 2, o is 0 to 2, Z is hydrogen or a pharmaceutical acceptable counterion, HPTA is 1,7-dicarboxy-2,6-bis(carboxymethyl)-4-hydroxy-2,6-diaza)-heptane, wherein said complex has a thermodynamic formation constant between 10 3 and 10 16 and wherein said complex shows a dissociation of greater than 50% and a half-life of less than 1 minute under physiological conditions; and (ii) 0 to 2 mol Ca 2+ per mol Mn 2+ ; b) exposing said body to a regime of physical and/or pharmacological stress before or simultaneously to the contrast agent administration; c) collecting MR imaging data and; d) providing MR images of an area of interest; and identifying the areas suffering from myocardial ischemia using the MR images.