Patent ID: 8252940

Claim:
A method for inhibiting Gram-negative bacterial pathogenesis associated with Type II and Type III secretion systems, comprising administering an effective amount of a compound to a subject in need thereof, wherein the compound has the formula: wherein, R 1 is selected from the group consisting of: (a) substituted and unsubstituted aryl, (b) substituted and unsubstituted heteroaryl, (c) substituted and unsubstituted alkyl, and (d) substituted and unsubstituted cycloalkyl; R 2 is substituted or unsubstituted aryl; and R 3 is —CH(R 4 )-Q-CH(R 5 )—Y, and Q is —C(═O)NH—, and Y is —C(═O)NH 2 , wherein R 4 and R 5 are independently selected from the group consisting of natural and non-natural amino acid side chains.