Patent ID: 8268827

Claim:
A compound of structural formula I: wherein: a is 0 or 1; b is 0 or 1; c is 0, 1, 2, 3 or 4; d is 1 or 2; e is 0, 1, 2, 3 or 4; f is 0, 1, 2, 3 or 4; A is a 6 to 15 membered monocyclic, fused, bridged or spiro saturated heterocyclic ring containing two N atoms and zero or one O atom, substituted by one oxo group; each R 1 is independently C 1-6 alkyl, haloC 1-6 alkyl, halogen or cyano; each R 2 is independently hydroxy, halogen, cyano, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy or NR a R b ; each of R 3 and R 4 is independently hydrogen, halogen, C 1-6 alkyl or haloC 1-6 alkyl; each R 5 is independently cyano, halogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 2-10 alkenyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl or a ring which is: C 3-10 cycloalkyl, C 6-10 aryl, C 6-10 aryloxy, oxetanyl, azetidinyl, a 5 or 6 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S, a 6 membered heteroaromatic ring containing 1, 2 or 3 N atoms or a 7-10 membered unsaturated, partially saturated or saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of which rings being optionally substituted by one, two or three groups independently selected from R 6 ; each R 6 is independently hydroxy, oxo, cyano, halogen, nitro, C 1-6 alkyl, C 1-6 alkoxy, C 2-10 alkenyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, —O(C═O)C 1-6 alkyl, —(C═O)OC 1-6 alkyl, NR a R b , CONR a R b , NR a COR b , S(O) r NR a R b , S(O) r R c , NR a S(O) r R c or a ring which is: C 3-10 cycloalkyl, C 6-10 aryl, C 6-10 arylC 1-6 alkyl, C 6-10 arylcarbonyl, C 6-10 aryloxycarbonyl, C 6-10 arylC 1-6 alkoxycarbonyl, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S or a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms; any of which rings being optionally substituted by one, two or three groups independently selected from halogen, C 1-6 alkyl or haloC 1-6 alkyl; r is 0, 1 or 2; each of R a and R b is independently hydrogen, C 1-6 alkyl or a ring which is: C 3-10 cycloalkyl, C 6-10 aryl, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S or a 6 membered heteroaromatic ring containing 1, 2 or 3 N atoms; any of which rings being optionally substituted by one, two or three groups independently selected from halogen, C 1-6 alkyl or haloC 1-6 alkyl; R c is hydrogen or C 1-6 alkyl; or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.