Patent ID: 7105550

Claim:
A method of inhibiting, suppressing, or antagonizing the production or activity of TNF-α (Tumor Necrosis Factor-alpha) or IL-12 (Interleukin 12) in a warm-blooded animal in need thereof comprising administering to the animal a therapeutically effective amount of a compound of the formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Q is phenyl, or naphthyl, each of said rings optionally being substituted with up to three substituents each independently selected from halo; hydroxy; cyano; carboxy; azido; amino; mono- or di(C 1-6 alkyl)amino; C 1-6 alkyl; C 2-6 alkenyl; C 2-6 alkynyl; C 3-6 cycloalkyl; C 1-6 alkyl substituted with hydroxy, C 1-6 alkyloxy, amino, mono- or di(C 1-4 alkyl)amino; C 1-6 alkyloxy; C 1-6 alkylthio; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; arylC 1-6 alkyloxy; aryloxy; polyhaloC 1-6 alkyl; polyhalo-C 1-6 alkyloxy; polyhaloC 1-6 alkylcarbonyl; C 1-4 alkyl-S(═O) n — or R 1 HN—S(═O) n —; n is an integer with value 1 or 2; R 1 represents hydrogen, or a radical of formula with A being O, S or a bivalent radical of formula —CR 2a ═N— with CR 2a attached to N of formula (a-1); and R 2 a being hydrogen, C 1-6 alkyl or C 1-6 alkyloxy; L is imidazopyridyl, optionally be substituted with up to 6 substituents, said substituents each independently being selected from halo, hydroxy, amino, cyano, carboxyl, mono-or di(C 1-4 alkyl)amino, C 1-6 alkyl, C 1-6 alkyl substituted with hydroxy or C 1-4 alkyloxy or amino or mono-or di(C 1-4 alkyl)amino, polyhaloC 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyloxy, aminocarbonyl, mono-or di(C 1-6 alkyl)aminocarbonyl, C 1-6 alkyl-C(═O)—NH—, C 1-6 alkyloxy-C(═O)—NH—, H 2 N—C(═O)—NH— or mono- or di(C 1-4 alkyl)amino-C(═O)—NH—; and aryl is phenyl, optionally substituted with up to five substituents each independently selected from halo, hydroxy, C 1-6 alkyl, polyhaloC 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, cyano, nitro, amino, and mono- or di-(C 1-6 alkyl)amino.