Patent ID: 8455516

Claim:
A compound, according to formula Va: wherein: Z 3 is —(CH 2 ) 0-3 CO 2 R a or H; each R a is independently H, C 1-6 alkyl, C 3-8 cycloalkyl, C 4-11 cycloalkylalkyl, C 6-10 aryl, C 7-16 arylalkyl, 3-10 membered heteroalicyclyl, 4-11 membered heteroalicyclylalkyl, 5-15 membered heteroaryl or 6-16 membered heteroarylalkyl; each R 2a is independently optionally substituted C 1-6 alkyl, halo, —OC 1-6 alkyl, —OH —N(C 1-6 alkyl) 2 , —N(H)C 1-6 alkyl, —CN, —NO 2 , —C(O)C 1-6 alkyl, —CO 2 H, —CO 2 C 1-6 alkyl, —C(O)N(H)C 1-6 alkyl or —C(O)N(C 1-6 alkyl) 2 ; each of R 3 and R 4 are, independently, —H, halo, optionally substituted C 1-6 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted C 4-11 cycloalkylalkyl, optionally substituted C 6-10 aryl, optionally substituted C 7-16 arylalkyl, optionally substituted 3-10 membered heteroalicyclyl, optionally substituted 4-11 membered heteroalicyclylalkyl, optionally substituted 5-15 membered heteroaryl or 6-16 membered heteroarylalkyl; and where each R 40 is independently C 1-6 alkyl, halo, —OC 1-6 alkyl, —OH, —N(R 80a ) 2 , perhaloalkyl, —CN, —NO 2 , —CO 2 C 1-6 alkyl or —C(O)NR 80a R 80a , where each R 80a is independently H or C 1-6 alkyl; and at least one of R 40 is —OC 1-6 alkyl.