Patent ID: 7452876

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is N(R 10 )(R 11 ); R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, alkoxy, or haloalkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 7 )(R 8 )NSO 2 , or (R 9 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; R 9 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from alkyl and alkoxy; R 10 is hydrogen, alkyl, alkoxyCO, or (R 12 )(R 13 )NCO; R 11 is hydrogen or alkyl; R 12 is hydrogen, alkyl, alkoxyalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (CO 2 R 14 )alkyl, (CON(R 15 )(R 16 ))alkyl, or (tetrahydropyranyl)alkyl; R 13 is hydrogen, alkyl, alkoxyalkyl, aminoalkyl, (alkylamino)alkyl, or (dialkylamino)alkyl; or (R 12 )(R 13 )N taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 substituents selected from alkyl and alkoxy; R 14 is hydrogen or alkyl; R 15 is hydrogen or alkyl; and R 16 is hydrogen or alkyl; or N(R 15 )(R 16 ) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 substituents selected from alkyl and alkoxy; or a pharmaceutically acceptable salt thereof.