Patent ID: 6962918

Claim:
A compound having a formula wherein R 0 , independently, is selected from the group consisting of halo and C 1-6 alkyl; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-3 alkyl, arylC 1-3 alkyl, and heteroarylC 1-3 alkyl; R 2 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-3 alkenylaryl, haloC 1-6 alkyl, C 1-4 alkyleneC(═O)OR a , C 1-4 alkyleneC(═O) NR a R b , C 3-8 cycloalkyl, Het, C 3-8 cycloalkenyl, C 3-8 heterocycloalkenyl, C 1-4 alkyleneHet, C 1-4 alkyleneQR a , C 2-6 alkenyleneQR a , C 1-4 alkyleneQC 1-4 alkyleneQR a , and a spiro substituent having the structure R 3 is selected from the group consisting of hydrogen and C 1-6 alkyl, R a and R b , independently, are selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylC 1-3 alkyl, heteroarylC 1-3 alkyl, C 1-3 alkylenearyl, C 1-3 alkyleneheteroaryl, and Het; R c is null or is selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylC 1-3 alkyl, heteroarylC 1-3 alkyl, C 1-3 alkylenearyl, C 1-3 alkyleneheteroaryl, and Het; Het is a 5- or 6-membered heterocyclic group, saturated or partially unsaturated, containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, and optionally substituted with C 1-4 alkyl or C(═O)OR a ; Q is O, S, or NR a ; W is O, S, or NR c ; X is O, S, or NR a ; Y is CR a or N; Z is CR a , G(R a ) 2 , or NR a ; and q is 0, 1, 2, 3, or 4, or a pharmaceutically acceptable salt or hydrate thereof.