Patent ID: 8748667

Claim:
A cationic lipid of Formula A: wherein: R 1 and R 2 are independently selected from (C 1 -C 6 )alkyl, heterocyclyl, and polyamine, wherein said alkyl, heterocyclyl and polyamine are optionally substituted with one to three substituents selected from R′, or R 1 and R 2 can be taken together with the nitrogen to which they are attached to form a monocyclic heterocycle with 4-7 members optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic heterocycle is optionally substituted with one to three substituents selected from R′; R′ is independently selected from halogen, R″, OR″, SR″, CN, CO 2 R″ or CON(R″) 2 ; R″ is independently selected from H and (C 1 -C 6 )alkyl, wherein said alkyl is optionally substituted with halogen and OH; L 1 is selected from C 4 -C 22 alkyl and C 4 -C 22 alkenyl, said alkyl and alkenyl are optionally substituted with one or more substituents selected from R′; and L 2 is selected from C 3 -C 13 alkyl and C 3 -C 13 alkenyl, said alkyl and alkenyl are optionally substituted with one or more substituents selected from R′; or any pharmaceutically acceptable salt or stereoisomer thereof.