Patent ID: 7157100

Claim:
A solid pharmaceutical composition for oral administration containing two or more layers forming a modified release bilayer fluoroquinolone tablet maintaining a therapeutically effective concentration with a once a day administration in the form of a floating bilayer controlled release system for the delivery of one or more active agents, comprising: a) at least one first controlled release layer containing an active agent and a disintegrating agent intended for immediate delivery and release thereby avoiding lag time; and followed by b) at least one second controlled release layer that includes an active agent for continuous controlled drug delivery, gas generating component, a matrix forming gelling agent which is intended for controlled delivery and release of the active agent for controlled drug delivery to maintain therapeutic effective concentrations with the once a day administration in a human body and also can be extended to veterinary use with appropriate modifications; and c) a third layer placed between the first and second layers comprising an inert excipients selected from the group consisting of lactose, mannitol, microcrystalline cellulose, starch, and dicalcium phosphate, and the optional third layer physically separates the first and second layers and facilitates delivery of two incompatible active agents wherein one of said active agent is a fluoroquinolone antibiotic.