Patent ID: 7268142

Claim:
A compound having the formula or a pharmaceutically acceptable salt, solvate or thereof, wherein Q is N or CH; wherein R 1 , R 2 and R 3 are each independently hydrogen, halogen, (C 1 -C 9 )alkyl, (C 2 -C 9 ) alkenyl, (C 2 -C 9 ) alkynyl, (C 3 -C 8 )cycoloalkyl, —O—(C 1 -C 9 ) alkyl, —O—(C 2 -C 9 ) alkenyl, (C 1 -C 6 )alkyl O—(C 1 - 6 )alkyl, —C≡N, —NO 2 , —COOR 4 , —CONR 4 R 5 , —NR 4 R 5 , COR 5 , or —COOH wherein said alkyl, alkenyl and alkynyl are optionally substituted with 1 to 3 halogens; wherein R 4 and R 5 are independently H, C 1 -C 6 alkyl, or (C 2 -C 6 )alkenyl) wherein said alkyl and alkenyl are optionally substituted with from 1 to 3 halogen atoms; and, when R 1 , R 2 and R 3 are independently —O-alkyl, —O-alkenyl, or alkyl, alkenyl or alkynyl, R 2 and R 1 or R 1 and R 3 may optionally be connected to form a methylenedioxy group; R 6 is hydrogen; R 7 is wherein X is a C 1 -C 6 alkyl group unsubstituted or substituted with one or more halogens, —O—C 1 -C 6 alkyl unsubstituted or substituted with one or more halogens, a (C 6 -C 14 ) aryl group unsubstituted or substituted with one or two substituents, a —NR 8 R 9 group or wherein said (C 6 -C 14 ) aryl group substituents are independently selected from C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, halogen, —C≡N, —NO 2 , —COOR 4 , —CONR 4 R 5 , —NR 4 R 5 , —COR 4 , and —COOH, and (C 1 -C 6 )alkyl substituted with 1 to 3 halogens; Y is hydrogen or (C 1 -C 6 )alkyl; n is 0 or 1; R 8 and R 9 are each independently (C 1 -C 6 )alkyl or hydrogen; Z is oxygen or NR 10 , wherein R 10 is hydrogen or (C 1 -C 6 )alkyl; wherein R 11 and R 12 are independently H, halogen, C═N, —COOH, —COOR 4 , —CONR 4 R 5 , COR 4 , —NR 4 R 5 , —OH, (C 6 -C 14 ) aryl, 5 to 12 membered heteroaryl, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl or (C 3 -C 8 ) cycloalkyl wherein said alkyl, alkenyl, and alkynyl are optionally independently substituted with from 1 to 3 halogens.