Patent ID: 6949241

Claim:
A method of preparing a biologically protected eye drop composition comprising a pharmaceutically active substance that is insoluble or only slightly soluble in water or physiological saline, which comprises the step of: applying under intense shaking to the pharmaceutically active substance, a lacrophyl preparation which comprises: (a) 0.1 to 1.0 weight % of egg white lysosoze; (b) 0.18 to 3.6 weight % of tris(hydroxymethyl)aminomethane; and (c) a natural lacrophyl comprising: (I) 0.5 to 1.0 weight % of citric acid; (ii) 0.5 to 1.0 weight % of boric acid; and/or (iii) 0.5 to 1.0 weight % of EDTA; and (iv) 0 to 10.0 weight % of ascorbic acid; and balance distilled water, in an amount effective to dissolve the pharmaceutically active substance in the lacrophyl preparation and to microbiologically protect the resulting eye drop composition.