Patent ID: 8268381

Claim:
A method of coating a medical device, comprising: applying a composition to at least a portion of a surface of a medical device, the composition comprising at least one bridged polycyclic compound, the at least one bridged polycyclic compound comprising at least two cyclic groups, wherein the at least one bridged polycyclic compound comprises a structure: wherein each R 1 is independently an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, N, N + R 3 , a heterocycle group, or a substituted heterocycle group; wherein each R 2 is independently an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocycle group, a substituted heterocycle group, a covalent bond, or an alkene; wherein each R 3 is independently an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocycle group, a substituted heterocycle group, an alkene, an ether, a polyethylene glycol, a benzyl group, a hydrogen, a hydrophilic group, or a polyethyleneimine; wherein each R 4 is independently an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocycle group, a substituted heterocycle, an ether, an amide, an alcohol, an ester, a sulfonamide, a sulfanilamide, or an alkene; wherein Z comprises at least one bridge, wherein at least one of the bridges is —R 2 —N + R 3 2 —R 4 —N + R 3 2 —R 2 —, —R 2 —NR 3 —R 4 —N + R 3 2 —R 2 —, —R 2 —NR 3 —R 4 —NR 3 —R 2 —, or —R 2 —N═R 4 ═N—R 2 —, and wherein each bridge independently couples R 1 to R 1 ; and wherein X comprises at least one negatively charged counter ion; and forming an antimicrobial coating over at least a portion of the surface.