Patent ID: 7972588

Claim:
A method for labelling a vector comprising reaction of a compound of formula (I) with a compound of formula (II): a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst, wherein: L1, L2, L3, and L4 are each independently a C 1-60 hydrocarbyl group optionally including 1 to 30 heteroatoms, alkyl, alkenyl, alkynyl chains, aromatic, polyaromatic, and heteroaromatic rings any of which may be optionally substituted with one or more ether, thiooether, sulphonamide, amide functional groups, amino acid, carbohydrate, or monomers and polymers comprising ethyleneglycol; vector is a peptide, protein, hormone, cell, bacterium, or virus; R* is a reporter moiety selected from the group consisting of radionuclides and radionuclides incorporated into a chelating agent wherein said chelating agent is a chelating agent of Formula X: where: each R 1A , R 2A , R 3A and R 4A is independently an R A group; each R A group is independently H or C 1-10 alkyl, C 3-10 alkylaryl, C 2-10 alkoxyalkyl, C 1-10 hydroxyalkyl, C 1-10 alkylamine, C 1-10 fluoroalkyl, or 2 or more R A groups, together with the atoms to which they are attached form a carbocyclic, heterocyclic, saturated or unsaturated ring; to give a conjugate of formula (V) or (VI) respectively: wherein L1, L2, L3, L4, vector and R* are as defined above.