Patent ID: 7728032

Claim:
A compound of the formula: wherein R 1 is selected from the group consisting of H, alkyl, aryl, heteroaryl, aryl substituted with from one to three substituents independently selected from the group consisting of halogen, loweralkyl, loweracyl, loweralkoxy, fluoroloweralkyl, fluoroloweralkoxy, hydroxyloweralkyl, formyl, cyano, and nitro; and heteroaryl substituted with from one to three substituents independently selected from the group consisting of halogen, loweralkyl, loweracyl, loweralkoxy, fluoroloweralkyl, fluoroloweralkoxy, formyl, cyano, and nitro; Het is pyrrolidine; Q is (CH 2 ) 1-8 ; in which one or two (CH 2 ) may optionally be replaced by —O—, —NR 1 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)—, provided that said —O—, —NR 1 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)— are separated by at least one —(CH 2 )—; and when the pyrrolidine nitrogen is the point of attachment to the parent structure, Q may additionally be a direct bond; Z is (CH 2 ) 1-10 ; in which one or two (CH 2 ) may optionally be replaced by —O—, —NR 1 —, —SO—, —S(O) 2 —, —C(═O)— or —C═O(NH)—, provided that said —O—, —NR 1 —, —SO—, —S(O) 2 —, —C(O)— or —C═O(NH)— are not at the point of attachment to nitrogen and are separated by at least one —(CH 2 )—; W is selected from acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, —COOalkyl, —CHO, sulfonamide, —C(O)fluoroalkyl, —C(O)CH 2 C(O)Oalkyl, —C(O)CH 2 C(O)Ofluoroalkyl, —SH, —C(O)NH(OH), —C(O)N(OH)R 4 , —N(OH)C(O)OH, —N(OH)C(O)R 4 , heterocyclyl, substituted aryl, and substituted heterocyclyl, or taken together ZW are H or —COOalkyl; and R 4 is selected from the group consisting of H and lower alkyl.