Patent ID: 8822451

Claim:
A compound of the formula: wherein Ra and Rb are each independently an optionally substituted hydroxyalkyl, an optionally substituted alkyloxyalkyl, an optionally substituted (heterocycloalkyl)alkyl, an optionally substituted (cycloalkyl)alkyl, an optionally substituted alkyloxycarbonylalkyl, an optionally substituted alkenyl, an optionally substituted alkenyl, an optionally substituted aralkyl or an optionally substituted heteroaralkyl; or Ra and Rb together with the nitrogen atom to which they are bound form an optionally substituted heterocycloaliphatic, or an optionally substituted heteroaryl; Each Rc is independently H; Each Rd is independently H; Ring A is an aryl or heteroaryl, each optionally substituted with 1-4 Re; Each Re is independently carboxy, amino, nitro, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkyl)alkylcarbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, sulfonyl, sulfinyl, sulfanyl, sulfoxy, sulfamoyl, sulfamide, ketal, carbamoyl, cyano, halo, urea, thiourea, haloalkyl, or —Z—Rf, in which each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl portion of the Re substituents is optionally substituted with 1-3 of Rg, or two Re, on adjacent A ring atoms, together with the A ring atoms to which they are bound form a heterocycloaliphatic ring; Each Z is absent, —O—, or —S—; Each Rf is independently hydrogen, alkyl, carboxyalkyl, hydroxyalkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, aroyl, heteroaroyl, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, or acyl, in which each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl portion of the Rf substituents is optionally substituted with 1-3 of Rg; Each Rg is independently halo, cyano, alkoxy, hydroxyl, nitro, haloalkyl, and alkyl; with the proviso that Ring A is not 7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-yl or 7-cyclopentylamino-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-yl.