Patent ID: 7696211

Claim:
A method of treating sepsis in a subject, the method comprising administering to the subject a therapeutically effective amount of an A 1 adenosine receptor antagonist in combination with an antibiotic agent used to treat sepsis, wherein the A 1 adenosine receptor antagonist is a compound of formula (I) in an amount sufficient to increase the survival rate of the subject wherein the compound of the formula (I) is: wherein R 1 is C 3 alkyl; R 2 is: wherein n is 2; R 5 is CH 3 (CH 2 ) p , wherein p is 1; and R 6 is (CH 2 ) m OH, wherein m is 2; R 3 is: —(CH 2 ) q C 6 H 4 —R 7 wherein q is 1; wherein R 7 is H; and R 4 is of the formula: wherein R 8 is NH 2 ; and r is 2.