Patent ID: 8889190

Claim:
An extended-release topiramate capsule comprising: a capsule shell comprising a single population of coated particles; wherein each coated particle comprises a core and a coating thereon; wherein each particle core comprises a homogeneous mixture throughout its core, the mixture comprising: 40 wt-% to 50 wt-% of topiramate, based on the total weight of an uncoated particle core; 45 wt-% to 55 wt-% of one or more filler(s), based on the total weight of an uncoated particle core; and 3 wt-% to 7 wt-% of one or more binder(s), based on the total weight of an uncoated particle core; wherein the coating comprises components including: one or more release controlling agent(s); one or more pore former(s); and one or more plasticizer(s); wherein the coating components are present in amounts that provide an extended release topiramate capsule; wherein, when a single dose is given to a healthy human subject, an AUC 0-inf of 170 to 210 h·μg/mL within a 95% confidence interval, and a C max of 2 to 4 μg/mL within a 95% confidence interval are achieved in the subject's plasma.