Patent ID: 8585942

Claim:
A method for controlling size and/or morphology characteristics of particles when producing a batch of particles of a substance in a production arrangement, said particles having predetermined sizes and/or morphology, comprising the steps of: i) mixing within a spray nozzle and under flow conditions a stream of a liquid solution in which the substance is dissolved or dispersed with a stream of a fluid, the kind of solvent in the solution, the kind of fluid and the proportion of the volume of the solution relative to the volume of the fluid being selected to promote nucleation and particle formation of the substance in the mixture, ii) passing said mixture in the form of a spray through a spray outlet of the nozzle into a particle collecting chamber, and iii) separating and collecting within said chamber said particles from said mixture, wherein the solvent is a liquid and the fluid is an aqueous liquid in a subcritical state, the pressure upstream and downstream of the spray nozzle is >1 bar and ≦30 bar, and the pressure drop across the spray nozzle is ≦30 bar.