Patent ID: 7361769

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein represents either (a) a single bond (b) a double bond, or (c) a cycloalkyl ring where the dashed line is —(CR 14 R 15 ) s -where s is 1, 2, 3 or 4; m is 0, 1 or 2; n is 0 or 1, where the sum of n and m is 1 to 3; p is 0, 1, 2, 3 or 4; X is selected from the group consisting of: R 1 is R 2 is where r is 0 or 1; R 3 is —(CR 5 R 6 ) 1-3 —NR 7 R 8 , or R 3 is where t is 1, 2, 3, 4 or 5; R 4 is hydrogen or alkyl; R 5 and R 6 can be the same or different, each being hydrogen or alkyl; R 7 is hydrogen, alkyl, acyl, alkoxycarbonyl, arylsulfonyl or alkylsulfonyl; R 8 is hydrogen, alkyl, acyl, —C(O)NH 2 , —C(O)NH-alkyl, —C(O)N(alkyl) 2 , alkoxycarbonyl, arylsulfonyl or alkylsulfonyl; R 9 is hydrogen or alkyl; R 10 is 1 to 3 moieties, each R 10 is independently selected from the group consisting of hydrogen, hydroxy, alkoxy, alkoxyalkyl, hydroxyalkyl, alkyl and halo, with the proviso that R 10 cannot be halo when it is attached to the carbon adjacent to N; R 11 is hydrogen, alkyl, alkoxyalkyl, hydroxyalkyl, acyl, alkoxycarbonyl, —C(O)NR 7 R 8 , alkylC(O)NR 7 R 8 , arylsulfonyl, alkylsulfonyl or -alkylC(O) 2 R 4 ; R 12 is 1 to 4 moieties, each R 12 is independently selected from the group consisting of hydrogen, alkyl, alkoxyalkyl or hydroxyalkyl; Ar is (R 13 ) u -substituted aryl, where u is a number from 1 to 3; and each R 13 is independently selected from the group consisting of hydrogen, hydroxy, halo, alkyl, alkoxy, —OCF 3 , —CF 3 , —SO 2 -alkyl, —NO 2 , —SCF 3 and —CN, or two R 13 moieties on adjacent carbons of the aryl or heteroaryl ring can be linked to form R 14 is hydrogen, alkyl, —CH 2 OH, halo, —CN, —OH, alkoxy or —NR 7 R 8 ; and R 15 is hydrogen, alkyl, —CH 2 OH, halo, —CN, —OH, alkoxy or —NR 7 R 8 .