Patent ID: 8685451

Claim:
A combination release tablet comprising: a) a drug-containing rapid release first compressed composition comprising filler, binder, disintegrant, and at least one drug selected from the group consisting of levodopa, carbidopa, ondansetron, quetiapine and ergotamine; b) a drug-containing extended release second compressed composition comprising filler, inorganic salt, a release rate modifier extended release polymer, and at least one drug selected from the group consisting of levodopa, alprazolam, quetiapine, divalproex and naproxen; and c) an osmotic device comprising a drug-containing core comprising filler, binder, and at least one drug, the core being surrounded by a membrane comprising cellulose ester and plasticizer and having a preformed passageway through it; wherein the first compressed composition and second compressed composition oppose one another, are in direct contact with, in stacked arrangement with respect to, and disposed on opposite faces or surfaces of the membrane, whereby the tablet provides three different active agent release profiles, and wherein the membrane is a semipermeable membrane, a microporous membrane, or an impermeable membrane.