Patent ID: 8354421

Claim:
A compound of Formula (I): or a pharmaceutically acceptable tautomer, salt, and/or ester thereof, wherein: R 1 and R 3 are each independently H, alkyl, or substituted alkyl; R 2 is carbocyclyl, substituted carbocyclyl, aryl, or substituted aryl; X 1 is alkylene or substituted alkylene; X 2 is a covalent bond; Z is —C(O)— or —NR 3 —C(O)—; Y is: L 1 is a covalent bond or —O—; R 4 is H, alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, -alkylene-C(O)—O—R 7 , -(substituted alkylene)-C(O)—O—R 7 , -alkylene-O—C(O)—O—R 7 , or -(substituted alkylene)-O—C(O)—O—R 7 ; and R 7 is H, alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, heterocyclylalkyl, or substituted heterocyclylalkyl; and provided that: when L 1 is a covalent bond, then R 4 is not H.