Patent ID: 7498298

Claim:
A compound having the formula: wherein: R 2 is selected from —H and —C 1 -C 8 alkyl; R 3 is selected from —H, —C 1 -C 8 alkyl, —C 3 -C 8 carbocycle, aryl, —C 1 -C 8 alkyl-aryl, —C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), —C 3 -C 8 heterocycle and —C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); R 4 is selected from —H, —C 1 -C 8 alkyl, —C 3 -C 8 carbocycle, -aryl, —C 1 -C 8 alkyl-aryl, —C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), —C 3 -C 8 heterocycle and —C 1 -C 8 alkyl-(C 3 -C 8 heterocycle) wherein R 5 is selected from —H and -methyl; or R 4 and R 5 jointly have the formula —(CR a R b ), wherein R a and R b are independently selected from —H, —C 1 -C 8 alkyl and —C 3 -C 8 carbocycle and n is selected from 2, 3, 4, 5 and 6, and form a ring with the carbon atom to which they are attached; R 6 is selected from —H and —C 1 -C 8 alkyl; R 7 is selected from —H, —C 1 -C 8 alkyl, —C 3 -C 8 carbocycle, aryl, —C 1 -C 8 alkyl-aryl, —C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), —C 3 -C 8 heterocycle and —C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); each R 8 is independently selected from —H, —OH, —C 1 -C 8 alkyl, —C 3 -C 8 carbocycle and —O—(C 1 -C 8 alkyl); R 9 is selected from —H and —C 1 -C 8 alkyl; R 10 is selected from aryl group and —C 3 -C 8 heterocycle; Z is —S—, —NH—, or —NR 12 —, wherein R 12 is C 1 -C 8 alkyl; R 11 is selected from —H, C 1 -C 20 alkyl, aryl, —C 3 -C 8 heterocycle, —(R 13 O) m —R 14 , and —(R 13 O) m —CH(R 15 ) 2 ; m is an integer ranging from 1 to 1000; R 13 is —C 2 -C 8 alkyl; R 14 is —H or —C 1 -C 8 alkyl; each occurrence of R 15 is independently —H, —COOH, —(CH 2 ) n —N(R 6 ) 2 , —(CH 2 ) n —SO 3 H, or —(CH 2 ) n —SO 3 —C 1 -C 8 alkyl; each occurrence of R 16 is independently —H, —C 1 -C 8 alkyl, or —(CH 2 ) n —COOH; and n is an integer ranging from 0 to 6; or a pharmaceutically acceptable salt thereof.