Patent ID: 8124122

Claim:
An external patch comprising a backing and a pressure-sensitive adhesive layer, wherein the backing is a laminate structure comprising a flexible film as an outer layer and a drug non-adsorptive layer, wherein said flexible film has a thickness of 1 to 200 μm and is selected from at least one of the group consisting of woven fabrics, non-woven fabrics and polymer films; wherein said drug non-adsorptive layer has a thickness of 0.1 to 10 μm and is a polyethylene terephthalate film; and wherein said pressure-sensitive adhesive layer is made of an acrylic pressure-sensitive adhesive, said pressure-sensitive adhesive layer being adjacent to said drug non-adsorptive layer and not adjacent to the flexible film, wherein the adhesive layer comprises: 0.01 to 1% by weight of an isocyanate-based crosslinking agent; 0.5 to 10% by weight of estradiol and/or a derivative of estradiol as an active ingredient dissolved in the adhesive layer; 0.5 to 10% by weight of crotamiton; and 0.1 to 10% by weight of oleic acid, and wherein the active ingredient is not adsorbed to the backing.