Patent ID: 8084466

Claim:
A chemical entity selected from the group consisting of compounds of Formula (I), and pharmaceutically acceptable salts of compounds of Formula (I): wherein R 1 is: a) an imidazol-2-yl ring, substituted with one or two R a substituents; where each R a substitutent is independently C 1-4 a1kyl, CF 3 , or a phenyl ring unsubstituted or substituted with one or two substituents independently selected from methyl, halo, and CF 3 ; b) a benzimidazol-2-yl ring, unsubstituted or substituted with one or two R b substituents; where each R b substituent is independently C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, phenyl, —CF 3 , —OCF 3 , —CN, halo, —NO 2 , —OC 1-4 alkyl, —SC 1-4 alkyl, —S(O)C 1-4 alkyl, —SO 2 C 1-4 alkyl, —C(O)C 1-4 alkyl, —C(O)phenyl, —C(O)NR c R d , —CO 2 C 1-4 alkyl, —CO 2 H, —C(O)NR c R d , or —NR c R d ; where R c and R d are each independently H or C 1-4 alkyl; or two R b substituents on adjacent carbon atoms taken together form —O(CH 2 ) 1-2 O—; or c) a ring system selected from the group consisting of: each ring system unsubstituted or substituted with C 1-4 alkyl, CF 3 , or halo; A is N or CR e ; where R 3 is H, methyl, or halo; each R 2 substituent is independently H, methyl, or halo; X is —(CH 2 ) 2 —, —C(R f )═C(R g )—, or —N═CH—, where R f is H, methyl, halo, or —CH 2 N(CH 3 ) 2 ; and R g is H or methyl; m is 1 or 2; n is 1 or 2; Z is N or CH; and R 3 is H or C 1-4 alkyl.