Patent ID: 7943616

Claim:
A compound of general formula (I):— wherein:— R 1 represents pyrrol-2-yl or indoly-2yl optionally substituted by —C(═O)—R; R 2 represents hydrogen; R 3 represents hydrogen, halo, or lower alkyl; R 4 represents —Z 3 R 7 ; R 5 represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; R 6 represents hydrogen or lower alkyl; R 7 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R 8 represents hydrogen or lower alkyl; R represents aryl or heteroaryl; alkenyl; or alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl each optionally substituted by a substituent selected from aryl, cycloalkyl, cyano, halo, heteroaryl, heterocycloalkyl, —CHO, —C(═OC)—NY 1 Y 2 , —C(═O)—OR 5 , —NY 1 Y 2 , —N(R 6 )—C(═O)—R 7 , —N(R 6 )—C(═O)—NY 3 Y 4 , —N(R 6 )—SO 2 —R 7 , —N(R 6 )—SO 2 —NY 3 Y 4 , —Z 3 R 7 and one or more groups selected from hydroxy, alkoxy and carboxy; X 1 represents N; Y 1 and Y 2 are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl or alkyl optionally substituted by one or more groups selected from aryl, halo, heteroaryl, heterocycloalkyl, hydroxy, —C(═O)—NY 3 Y 4 , —C(═O)—OR 5 , —NY 3 Y 4 , —N(R 6 )—C(═O)—R 7 , —N(R 6 )—C(═O)—NY 3 Y 4 , —N(R 6 )—SO 2 —R 7 , —N(R 6 )—SO 2 —NY 3 Y 4 and —OR 7 ; or the group —NY 1 Y 2 may form a cyclic amine; Y 3 and Y 4 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or the group —NY 3 Y 4 may form a cyclic amine; Z 2 represents O or S(O) n ; Z 3 represents O, S(O) n , NR 6 ; n is zero or an integer 1 or 2; or an N-oxide, pharmaceutically acceptable salt of such compound; or an N-oxide, of such salt; together with one or more pharmaceutically acceptable carriers or excipients.