Patent ID: 7297538

Claim:
An in vitro encapsulated cell indicator system comprising a culture vessel comprising: (a) a first population of bone marrow stem cells (BMSCs) comprising an enhancer element selected from csx, bves, tie-2, von Willebrand, flk-1, ICAM-2, PPAR-γ2, TRAP, osteocalcin, CD11b, nestin, neurofilament, GFAP, myoD, SMHC, pdx-1, glucokinase, and α-fetoprotein enhancer elements, operably linked to a reporter gene; (b) encapsulating material; (c) a permeable membrane; wherein said cells are encapsulated in said encapsulating material, and said encapsulating material and said cells are contained within said permeable membrane; and (d) a second population of BMSCs that are separated from said first population by said permeable membrane.