Patent ID: 6921750

Claim:
A peptide of formula (I): wherein A 1 is Ser, Ala, or Dap; A 3 is Ser, Thr, or Aib; A 5 is Leu, Nle, Ile, Cha, β-Nal, Trp, Pal, Acc, Phe or p-X-Phe, in which X is OH, a halogen, or CH 3 ; A 7 is Leu, Nle, Ile, Cha, β-Nal, Trp, Pal, Acc, Phe, or p-X-Phe in which X is OH, a halogen, or CH 3 ; A 8 is Met, Nva, Leu, Val, Ile, Cha, Acc or Nle; A 11 is Leu, Nle, Ile, Cha, β-Nal, Trp, Pal, Acc, Phe or p-X-Phe in which X is OH, a halogen, or CH 3 ; A 12 is Gly, Acc or Aib; A 15 is Leu, Nle, Ile, Cha, β-Nal, Trp, Pal, ACC, Phe, or p-X-Phe in which X is OH, a halogen, or CH 3 ; A 16 is Ser, Asn, Ala, or Aib; A 17 is Ser, Thr, or Aib; A 18 is Met, Nva, Leu, Val, Ile, Nle, Acc, Cha, or Aib; A 19 is Glu or Aib; A 21 is Val, Acc, Cha, or Met; A 22 is Acc or Glu; A 23 is Trp, Acc, or Cha; A 24 is Leu, Acc, or Cha; A 27 is Lys, Aib, Leu, hArg, Gln, Acc, or Cha; A 28 is Leu, Acc, or Cha; A 29 is Gln; A 30 is Asp or Lys; A 31 is Val, Leu, Nle, Acc, Cha, or deleted; A 32 is His or deleted; A 33 is Asn or deleted; A 34 is Phe, Tyr, Amp, Aib, or deleted; each of R 1 and R 2 is, independently, H, C 1-12 alkyl, C 2-12 alkenyl, C 7-20 phenylalkyl, C 11-20 naphthylalkyl, C 1-12 hydroxyalkyl, C 2-12 hydroxyalkenyl, C 7-20 hydroxyphenylalkyl, or C 7-20 hydroxynaphthylalkyl; or one and only one of R 1 and R 2 is COE 1 in which E 1 is C 1-12 alkyl, C 2-12 alkenyl, C 7-20 phenylalkyl, C 11-20 naphthylalkyl, C 1-12 hydroxyalkyl, C 2-12 hydroxyalkenyl, C 7-20 hydroxy-phenylalkyl, or C 11-120 hydroxynaphthylalkyl; and R 3 is OH, NH 2 , C 1-12 alkoxy, or NH—Y—CH 2 -Z in which Y is a C 1-12 hydrocarbon moiety and Z is H, OH, CO 2 H, or CONH 2 ; provided that at least one of A 5 , A 7 , A 8 , A 11 , A 12 , A 15 , A 18 , A 21 , A 22 , A 23 , A 24 , A 27 , A 28 , and A 31 is Acc; or a pharmaceutically acceptable salt thereof.