Patent ID: 8821850

Claim:
A conjugate comprising an antibody and one or more D-carrying polymeric scaffolds connected to the antibody, each polymeric scaffold having Formula (Ic): wherein: each occurrence of D is independently a therapeutic agent having a molecular weight of ≦5 kDa; each D-carrying polymeric scaffold comprises poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) having a molecular weight ranging from about 2 kDa to about 40 kDa; L D1 is a carbonyl-containing moiety; each occurrence of in is independently a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; and the in between L D1 and D denote's direct or indirect attachment of D to L D1 ; each occurrence of is independently a second linker not yet connected to the antibody, in which L P2 is a moiety containing a functional group that is yet to form a covalent bond with a functional group of the antibody, and the between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1 , and each occurrence of the second linker is distinct from each occurrence of the first linker; each occurrence of is independently a third linker that connects each D-carrying polymeric scaffold to the antibody in which the terminal attached to L P2 denotes direct or indirect attachment of L P2 to the antibody upon formation of a covalent bond between a functional group of L P2 and a functional group of the antibody; and each occurrence of the third linker is distinct from each occurrence of the first linker; m is an integer from 1 to 300, m 1 is an integer from 1 to 140, m 2 is an integer from 1 to 40, m 3 is an integer from 0 to 18, m 4 is an integer from 1 to 10; and the sum of m, m 1 , m 2 , m 3 , and m 4 ranges from 15 to 300; provided that the total number of L P2 connected to the antibody is 10 or less.