Patent ID: 8569008

Claim:
A method for fabricating a biomemory device which is a write once read many (WORM) type device or a write read erase read (WRER) type device, comprising: (a) substituting an original metal ion of a metalloprotein having a redox potential with metal ion which is different from the original metal ion, and is magnesium, vanadium, manganese, iron, nickel, zinc, molybdenum, cobalt, gallium, bismuth, gold, aluminum, platinum, chromium, silver, antimony, thallium, cadmium, mercury, lead, calcium, or selenium, wherein the metalloprotein is azurin, hemoglobin, myoglobin, hemerythrin, cytochrome, iron-sulfur protein, rubredoxin, plastocyanin, ferritin, ceruloplasmin, carbonic anhydrase, vitamin B 12 -dependent enzyme, nitrogenase, superoxide dismutase, chlorophyll-containing protein, calmodulin, glucose 6-phosphatase, hexokinase, DNA polymerase, vanabin, arginase, catalase, hydrogenase, iron-responsive element-binding protein, aconitase, urease, cytochrome oxidase, laccase, alcohol dehydrogenase, carboxypeptidase, aminopeptidase, β-amyloid, nitrate reductase, glutathione peroxidase, metallothionein, or phosphatase, and is a recombinant protein into which a cysteine residue is introduced; and (b) immobilizing the metalloprotein on a substrate.