Patent ID: 7632866

Claim:
A pharmaceutical composition comprising, as an active ingredient, a compound having the general Formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is an A-G(═K)—X—Y group, and wherein: A is alkyl or absent; G is C; K is selected from the group consisting of O and S; X is NRb; and Y is selected from the group consisting of a substituted or unsubstituted hydroxyalkyl and a substituted or unsubstituted polyalkylene glycol residue having a general formula III: [(CH 2 )m-O]n-R 17 Formula III wherein: each of m and n is independently an integer of 1-10; and R 17 is hydrogen, alkyl, cycloalkyl or aryl; R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl or aryl; each of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, amino and —NR 15 R 16 , or, alternatively, at least two of R 2 , R 3 , R 4 , R 5 and R 6 , of R 7 , R 8 , R 9 and R 10 and/or of R 11 , R 12 , R 13 and R 14 form a five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring; R 15 and R 16 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl and sulfonyl, or, alternatively R 15 and R 16 form a five- or six-member heteroalicyclic ring; and each of Ra, Rb and Rc is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl, wherein when Y is a polyalkylene glycol residue, said polyalkylene glycol residue does not include a —ONO 2 group or an antioxidant residue, and a pharmaceutically acceptable carrier.