Patent ID: 7563788

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: X 1 is CH 2 , NH, or O; X 2 is absent, or is (CH 2 ) x′ , NH, O, or wherein “ ” are points of attachment, or is a tether 2, 3 or 4 atoms in length, selected from wherein R is H or (C 1 -C 6 )alkyl, and wherein “ ” are points of attachment and x′ is an integer from 1 to 3; Y is C—H, C—F, or C—OMe; R 1 is H or halo; R 2 is (C 3 -C 6 )cycloalkyl, (CH 2 ) x -aryl, (CH 2 ) x -heterocyclyl, or (CH 2 ) x -heteroaryl, wherein x is 0, 1, or 2; R 3 is H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, heterocyclyl, heteroaryl, C(O)NR a R b , C(O)R a , CO 2 R a , C(O)C(O)NR a R b , NO 2 , SO 2 R a , SO 2 NR a R b , C(R c )═NOR a , C(R c )═NR a , wherein “ ” indicates the point of attachment, wherein “ ” indicates the point of attachment, and wherein R a is H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (CH 2 ) y -aryl, (CH 2 ) y -heterocycyl, or (CH 2 ) y -heteroaryl, wherein y is 0, 1, or 2; R b is H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, heterocyclyl, or heteroaryl; R c is H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, heterocyclyl, or heteroaryl; and R 4 is (C 1 -C 6 )alkyl, (C 1 -C 6 alkyl)-O—(C 1 -C 6 alkyl), cyclopropyl, CH 2 -cyclopropyl, or cyclobutyl.