Patent ID: 7414061

Claim:
An aryl-isoxazol-4-yl-imidazole derivative of formula I: wherein R 1 , R 2 , and R 3 are each independently hydrogen or halogen; R 4 is hydrogen, lower alkyl, cycloalkyl, —(CH 2 ) n —O-lower alkyl or lower alkyl substituted by hydroxy; R 5 is —(CH 2 ) m -aryl or —(CH 2 ) m -heteroaryl, each of which is optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkyl substituted by halogen, —C(O)-lower alkyl, —C(O)—O-lower alkyl, —NH—C(O)—O-lower alkyl and —C(O)—NH—R′, wherein R′ is lower alkynyl or is lower alkyl substituted by halogen, or is —(CH 2 ) n -cycloalkyl, —(CH 2 ) n -heterocyclyl, —(CH 2 ) n -heteroaryl or —(CH 2 ) n -aryl, each of which is optionally substituted by halogen; R 6 is hydrogen, —C(O)H, —(CH 2 ) n —O-lower alkyl, —C(O)O-lower alkyl, lower alkyl substituted by hydroxy or halogen, cycloalkyl, aryl, —(CH 2 ) n —O—CH 2 -aryl, optionally substituted by halogen or lower alkyl, —(CH 2 ) n —O—CH 2 -heteroaryl, optionally substituted by halogen, lower alkyl or lower alkyl substituted by halogen, or —(CH 2 ) n —NH—(CH 2 ) o -heterocyclyl; n is 0, 1, 2 or 3 m is 0 or 1; and o is 1, 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.