Patent ID: 7928243

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof wherein A 1 , A 4 and A 5 are each C(R 1 ); one of A 2 and A 3 is C(-L 2 -R 2 ) and the other is N or C(R 1 ); R 1 at each occurrence is independently hydrogen, alkyl, halogen or haloalkyl; R 2 is alkyl, aryl or heteroaryl; wherein the aryl and heteroaryl are independently unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of —CN, —NO 2 , alkyl, haloalkyl, —O(R a ), —S(R a ), —S(O)R a′ , —S(O) 2 R a′ , —NR a R b , —OC(O)R a′ , —N(R b )C(O)R a , —N(R b )S(O) 2 R a′ , —N(R b )C(O)OR a , —N(R b )C(O)NR a R b , —N(R b )S(O) 2 NR a R b , —C(O)R a , —C(O)OR a —C(O)NR a R b , —S(O) 2 NR a R b , —(CR y R z ) n —CN, —(CR y R z ) n —NO 2 , —(CR y R z ) n —O(R a ), —(CR y R z ) n —S(R a ), —(CR y R z ) n —S(O)R a′ , —(CR y R z ) n —S(O) 2 R a′ , —(CR y R z ) n —NR a R b , —(CR y R z ) n —OC(O)R a′ , —(CR y R z ) n —N(R b )C(O)R a , —(CR y R z ) n —N(R b )S(O) 2 R a′ , —(CR y R z ) n —N(R b )C(O)OR a , —(CR y R z ) n —N(R b )C(O)NR a R b , —(CR y R z ) n —N(R b )S(O) 2 NR a R b , —(CR y R z ) n —C(O)R a , —(CR y R z ) n —C(O)OR a , —(CR y R z ) n —C(O)NR a R b , and —(CR y R z ) n —S(O) 2 NR a R b ; L 1 is O; L 2 is O or C(R y R z ) m ; R x at each occurrence is independently hydrogen, alkyl or haloalkyl; m and n at each occurrence are independently 1, 2 or 3; R a at each occurrence is independently hydrogen, alkyl, alkenyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, R a′ at each occurrence is independently alkyl, alkenyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, R b at each occurrence is independently hydrogen, alkyl, alkenyl or haloalkyl; wherein the aryl, heteroaryl, aryl moiety of the arylalkyl and the heteroaryl moiety of the heteroarylalkyl as represented by R a and R a′ are independently unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of alkyl, haloalkyl, alkenyl, hydroxy, alkoxy, —N(H) 2 , —N(H)(alkyl), —N(alkyl) 2 , —C(O)H, —C(O)alkyl, —C(O)OH, —C(O)O(alkyl), —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , —CN and —NO 2 , A is thiazolyl and is connected to L 1 and X through the carbon atoms in the ring; A is optionally further substituted with 1 or 2 substituents selected from the group consisting of alkyl, halogen, haloalkyl and hydroxyalkyl; X is —C(H)═N—O—(CR y R z ) p —NR d R e , or —C(CR y R z ) q —NR d R e ; R y and R z at each occurrence are independently hydrogen, alkyl, haloalkyl or hydroxyalkyl; p at each occurrence is independently 2 or 3; q at each occurrence is independently 1, 2 or 3; R d at each occurrence is independently hydrogen, alkyl, haloalkyl, —C(O)(alkyl), —C(O)N(H) 2 , —C(O)N(H)(alkyl) or —C(O)N(alkyl) 2 ; and R e at each occurrence is independently hydrogen, alkyl or haloalkyl.