Patent ID: 7531547

Claim:
A compound of formula (1): or a pharmaceutically acceptable salt thereof, wherein: X is: —CR 2 —; —O—; —S(O) n —; or —NR c — wherein n is from 0 to 2 and R c is hydrogen or alkyl; D is an optional oxygen; R 1 is: ethyl; isopropyl; iodo; ethynyl; or cyclopropyl; R 2 , R 4 and R 6 are hydrogen; R 3 is: hydrogen; alkyl; alkenyl; amino; halo; amido; haloalkyl; alkoxy; hydroxy; haloalkoxy; nitro; amino; hydroxyalkyl; alkoxyalkyl; hydroxyalkoxy; alkynylalkoxy; alkylsulfonyl; arylsulfonyl; cyano; aryl; heteroaryl; heterocyclyl; heterocyclylalkoxy; aryloxy; heteroaryloxy; aralkyloxy; heteroaralkyloxy; optionally substituted phenoxy; —C=C—R u ; —(CH 2 ) m -(Z) n -(CO)—R b ; —(CH 2 ) m -(Z) n -SO 2 —(NR c ) n R b wherein m and n each independently is 0 or 1, Z is O or NR c , R a is hydrogen; alkyl; aryl; aralkyl; heteroaryl; heteroaralkyl; hydroxyalkyl; alkoxyalkyl; alkylsulfonylalkyl; aminoalkyl; cyanoalkyl; alkylsilyl, cycloalkyl, cycloalkylalkyl; heterocycl; and heterocyclylalkyl; R b is hydrogen, alkyl, hydroxy, alkoxy, amino, hydroxyalkyl or alkoxyalkyl, and each R c is independently hydrogen or alkyl; or R 2 and R 3 together with the atoms to which they are attached may form a five or six-membered ring that optionally includes one or two heteroatoms selected from O, S and N; R 5 is: hydrogen; alkyl; aryl; aralkyl; heteroaryl; heteroaralkyl; hydroxyalkyl; alkoxyalkyl; alkylsulfonylalkyl; aminoalkyl; cyanoalkyl; alkylsilyl, cycloalkyl, cycloalkylalkyl; heterocycl; or heterocyclylalkyl; and R 7 and R 8 each independently is: hydrogen; alkyl; aminoalkyl; aminosulfonyl; cycloalkyl; cycloalkylalkyl; haloalkyl; haloalkoxy; hydroxyalkyl; alkoxyalkyl; alkylsulfonyl; alkylsulfonylalkyl; aminocarbonyloxyalkyl; hydroxycarbonylalkyl; hydroxyalkyloxycarbonylalkyl; aryl; aralkyl; arylsulfonyl; heteroaryl; heteroarylalkyl; heteroarylsulfonyl; heterocyclyl; or heterocyclylalkyl.