Patent ID: 8552212

Claim:
A compound of formula (Ia), (Ib), or a mixture thereof: wherein: X is O or S; R 1 is —(C 1 -C 6 )alkyl, —CF 3 , —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl, -(5 to 11-membered)heteroaryl, or ferrocenyl; wherein said —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl and -(5 to 11-membered)heteroaryl of said R 1 is optionally substituted with 1 to 3 substituents independently selected from —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, and —CF 3 ; R 2 is H, —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl, -(5 to 11-membered)heteroaryl, —NR 5 R 6 , or —SR 5 ; wherein said —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl, and -(5 to 11-membered)heteroaryl of said R 2 is optionally substituted with 1 to 3 substituents independently selected from —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, and —CF 3 ; R 3 is —PR 7 R 8 , —CH 2 PR 7 R 8 , —CH 2 OPR 7 R 8 , or a group of formula (A) or (B): wherein X, R 1 and R 2 of the group of formula (A) or (B) are as defined above, and wherein the group of formula (A) only joins to the compound of formula (Ia), and the group of formula (B) only joins to the compound of formula (Ib); R 4 is H, —(C 1 -C 6 )alkyl, —(C 3 -C 6 )cycloalkyl, -(3- to 6-membered)heterocycloalkyl, phenyl, (5- to 6-membered)heteroaryl, or —SiR 5 3 ; wherein said —(C 1 -C 6 )alkyl of said R 4 is optionally substituted with 1 to 3 substituents independently selected from —O(C 1 -C 6 )alkyl, —(C 3 -C 6 )cycloalkyl, phenyl, and -(5- to 6-membered)heteroaryl; and wherein said —(C 3 -C 6 )cycloalkyl, -(3- to 6-membered)heterocycloalkyl, phenyl, and (5- to 6-membered)heteroaryl of said R 4 is optionally substituted with 1 to 3 substituents independently selected from —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, and —CF 3 ; R 5 and R 6 are each independently H, —(C 1 -C 6 )alkyl, —CF 3 , —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl, or -(5 to 11-membered)heteroaryl; wherein each —(C 1 -C 6 )alkyl, —CF 3 , —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl, and -(5 to 11-membered)heteroaryl of said R 5 and R 6 is optionally independently substituted with 1 to 3 substituents independently selected from halo, —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, and —CF 3 ; and R 7 and R 8 are each independently —(C 1 -C 6 )alkyl, —CF 3 , —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl, -(5 to 11-membered)heteroaryl, or ferrocenyl; wherein said —(C 3 -C 10 )carbocyclyl, -(5- to 11-membered)heterocarbocyclyl, —(C 6 -C 10 )aryl and -(5 to 11-membered)heteroaryl of said R 7 and R 8 are each optionally independently substituted with 1 to 3 substituents independently selected from —O(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl, and —CF 3 .