Patent ID: 8735384

Claim:
A compound, or a stereoisomer or pharmaceutically acceptable salt thereof, having a Formula I-B-I wherein B 1 is —CF, —CCH 3 or CH; each R 1 , independently, is halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-7 -cycloalkyl, C 4-7 -cycloalkenyl, C 1-6 -alkylamino-, C 1-6 -dialkylamino-, C 1-6 -alkoxyl, C 1-6 -thioalkoxyl, —C(O)—R 3 , —C(O)NHR 3 , —C(O)OR 3 or —C(O)NR a R b , wherein R a is H or C 1-6 alkyl and R b is R 3 , alternatively, R a and R b taken together with the nitrogen atom to which they are attached form a 4-7 membered monocyclic heterocycle, optionally substituted with 1-3 substituents of R 3 ; or R 1 is a fully saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of R 3 ; each R 2 independently, is F, Cl, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, —OCF 3 , —NH 2 , NHCH 3 or —C(O)CH 3 ; each R 3 , independently, is halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, oxo, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a fully saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, haloalkoxyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -thioalkoxyl, benzyl or phenyl; m is 0 or 1; and n is 0 or 1.