Patent ID: 8207198

Claim:
A compound of formula (I): wherein: m is 2 and n is 2; X is selected from O, NH, N(C 1 -C 6 )alkyl, NC(O)(C 1 -C 6 )alkyl, N(SO 2 (C 1 -C 6 )alkyl), S and SO 2 ; R 1 is phenyl or naphthyl; wherein said phenyl or naphthyl is optionally substituted with one to three substituents independently selected from halo, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, cyano, CF 3 , NH(C 1 -C 6 )alkyl, N((C 1 -C 6 )alkyl) 2 , CO(C 1 -C 6 )alkyl, C(O)O(C 1 -C 6 )alkyl, C(O)NH(C 1 -C 6 )alkyl, C(O)N((C 1 -C 6 )alkyl) 2 , C(O)OH and C(O)NH 2 ; R 2 is selected from: (i) H and hydroxy; (ii) (C 1 -C 6 )alkyl, which is optionally substituted with a O(C 1 -C 6 )alkyl or phenyl; (iii) O(C 1 -C 6 )alkyl, which is optionally substituted with a O(C 1 -C 6 )alkyl; (iv) NH(C 1 -C 6 )alkyl, wherein said alkyl group is optionally substituted with a O(C 1 -C 6 )alkyl; (v) N((C 1 -C 6 )alkyl) 2 , wherein one or both of said alkyl groups is optionally substituted by with a O(C 1 -C 6 )alkyl; R 3 is selected from H, (C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl; R 4 , R 5 , R 6 and R 7 are each independently selected from H, halo, hydroxy, CN, (C 1 -C 6 )alkyl, NH(C 1 -C 6 )alkyl, H((C 1 -C 6 )alkyl) 2 and O(C 1 -C 6 )alkyl; and R 8 is selected from H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, CH 2 OH, CH 2 NH 2 , CH 2 NH(C 1 -C 6 )alkyl, CH 2 N((C 1 -C 6 )alkyl) 2 , CN, C(O)NH 2 , C(O)NH(C 1 -C 6 )alkyl and C(O)N((C 1 -C 6 )alkyl) 2 ; a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.