Patent ID: 7078426

Claim:
A compound having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein X is one of O, S or CH 2 ; Het is R 1 is selected from the group consisting of hydrogen, optionally substituted alkyl, heteroaryl optionally substituted with one or more groups independently selected from the group consisting of halo, halo(C 1-6 )alkyl, hydroxy(C 1-6 )alkyl, amino(C 1-6 )alkyl, hydroxy, nitro, C 1-6 alkyl, C 1-6 alkoxy, aminocarbonyl, carbamoyloxy, C 1-6 alkylsulfonylamino, C 1-6 acyl and amino, C(O)R 10 , CH 2 C(O)R 10 , S(O)R 10 , and SO 2 R 10 ; R 2 and R 3 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, cyano, aminoalkyl, hydroxyalkyl, alkoxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, carboxyalkyl, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, alkylcarbonyl, aminosulfonyl, alkylaminosulfonyl, and alkylsulfonyl; R 5 , R 6 , R 7 , and R 8 are independently selected from the group consisting of hydrogen, halo, haloalkyl, alkyl, alkenyl, alkynyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, alkoxyalkyl, nitro, amino, ureido, cyano, acylamino, amide, hydroxy, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido and alkylthiol; R 10 is selected from the group consisting of amino, alkyl, alkenyl, alkynyl, OR 11 , alkylamino, dialkylamino, alkenylamino, dialkylaminoalkenyl, cycloalkyl, heterocycle, heteroaryl, aryl, aralkyl, arylalkenyl, arylalkynyl, and cycloalkylalkylamino, all of which are optionally substituted; and R 11 is selected from the group consisting of hydrogen, optionally substituted alkyl, and an alkalimetal.