Patent ID: 7696204

Claim:
A compound which is a pyrimidine of formula (I): wherein —XR 3 is bonded at ring position 2 and —YR 4 is bonded at ring position 5 or 6, or —YR 4 is bonded at ring position 2 and —XR 3 is bonded at ring position 6; R 1 and R 2 form, together with the N atom to which they are attached, a morpholine ring which is unsubstituted or substituted; X is selected from a direct bond, —O—, —CR′R″— and —NR′— wherein R′ and R″ are each, independently, H or C 1 -C 6 alkyl; R 3 is an indole group which is unsubstituted or substituted; and either: (a) Y is selected from —O—(CH 2 ) n —, —NH—(CH 2 ) n —, —NHC(O)—(CH 2 ) n — and —C(O)NH—(CH 2 ) n — wherein n is 0 or an integer of 1 to 3, and R 4 is selected from an unsaturated 5- to 12-membered carbocyclic or heterocyclic group which is unsubstituted or substituted, and a group —NR 5 R 6 wherein R 5 and R 6 , which are the same or different, are each independently selected from H, C 1 -C 6 alkyl which is unsubstituted or substituted, C 3 -C 10 cycloalkyl which is unsubstituted or substituted, —C(O)R, —C(O)N(R) 2 and —S(O) m R wherein R and m are as defined above, or R 5 and R 6 together form, with the nitrogen atom to which they are attached, a saturated 5-, 6- or 7-membered N-containing heterocyclic group which is unsubstituted or substituted; (b) Y is a direct bond and R 4 is selected from an unsaturated 5- to 12-membered carbocyclic or heterocyclic group which is unsubstituted or substituted, and a group —NR 5 R 6 wherein R 5 and R 6 , which are the same or different, are each independently selected from H, C 1 -C 6 alkyl which is unsubstituted or substituted, C 3 -C 10 cycloalkyl which is unsubstituted or substituted, —C(O)R, —C(O)N(R) 2 and —S(O) m R wherein R and m are as defined above; or a pharmaceutically acceptable salt thereof.