Patent ID: 8148404

Claim:
A compound of formula (IB), or a salt, single enantiomer or N-oxide thereof: WHEREIN: A 1 is tetrazolyl; p and q are independently 0 or 1; A 3 is phenyl or cycloalkyl, either of which is optionally substituted with R 4 and/or R 5 ; R 4 and R 5 independently —R 9 , —CN, —F, —Cl, —Br, —OR 9 , —NR 7 R 8 , —NR 7 COR 6 , —NR 7 SO 2 R 6 , —COR 6 , —SR 9 , —SOR 9 or —SO 2 R 6 ; R 6 is C 1 -C 4 alkyl, cycloalkyl, —CF 3 or —NR 7 R 8 ; R 7 and R 8 are independently hydrogen, C 1 -C 4 alkyl or cycloalkyl; R 9 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkoxy(C 1 -C 4 alkyl)-, cycloalkyl, fully or partially fluorinated C 1 -C 4 alkyl; R 1 is (i) a bond, or (ii) —(CH 2 ) a B 1 (CH 2 ) b — wherein a and b are independently 0, 1, 2 or 3 provided that a+b is not greater than 4, and B 1 is —CO—, —O—, —S—, —SO—, —SO 2 —, —CH 2 —, —CHOH— or —NR 7 —; or (iii) a divalent radical selected from —C(R 10 )(R 11 )—*, —C(R 10 )(R 11 )—O—*, —C(R 10 )(R 11 )CH 2 —*, —C(R 10 )(R 11 )CH 2 —O—*, —CH 2 C(R 10 )(R 11 )—*, —CH 2 C(R 10 )(R 11 )—O—*, —CH 2 —O—C(R 10 )(R 11 )—* and —C(R 10 )(R 11 )—O—CH 2 —*, wherein the bond indicated by an asterisk is attached to the pyrazole ring; R 10 is hydrogen and R 11 is (C 1 -C 3 )alkyl; or R 10 and R 11 are both (C 1 -C 3 )alkyl; or R 10 and R 11 taken together with the carbon atom to which they are attached form a (C 3 -C 5 )cycloalkyl ring; and the group —N(R 3 )R 2 -A 2 has formula (II) or (IV): wherein x and y are independently 0 or 1, and j is 1, 2, 3 or 4; B 3 is —C(R 13 )(R 14 )—, —O—, or —NR 7 —, or in either orientation —O—C(R 13 )(R 14 )—, —CH 2 —C(R 13 )(R 14 )—; B 4 is —C(R 13 )(R 14 )—, —CO—, —SO 2 —, —O—, or in either orientation O—C(R 13 )(R 14 )—, —CH 2 —C(R 13 )(R 14 )—; A 2 is hydrogen, —COOH, tetrazolyl, —CN, —CF 3 , —COR 6 , —SO 2 R 6 , —OR 9 , —NR 7 R 8 , —NR 7 COR 6 , or —NR 7 SO 2 R 6 ; A 4 is a monocyclic carbocyclic or monocyclic heterocyclic ring, having 3 to 8 ring atoms, optionally substituted with one or more of —F, —Cl, —Br, —CN, —CF 3 , C 1 -C 4 alkyl, cycloalkyl, —OR 9 , oxo or —NR 7 R 8 ; and R 13 and R 14 are independently hydrogen or (C 1 -C 3 )alkyl; or R 13 and R 14 are both (C 1 -C 3 )alkyl; or R 13 and R 14 taken together with the carbon atom to which they are attached form a (C 3 -C 5 )cycloalkyl ring.