Patent ID: 7405324

Claim:
Process for synthesizing acetamido adamantanes of formula II in which R1 and R2 are identical or different, and are H or a straight or branched alkyl group, comprising from 1 to 6 carbon atoms, from a halogen adamantane of formula III in which R1 and R2 are as above, and in which X is F, Cl, Br or I, comprising the following steps: (a1) feeding into a reaction vessel a mixture comprising the halogen adamantane of formula III, 5-10 equivalents of acetonitrile and 5-20 equivalents of glacial acetic acid, to provide a reaction mixture, (b1) introducing into the reaction mixture 3-10 equivalents of concentrated sulfuric acid, to provide a reacted mixture, or, alternatively: (a2) feeding into a reaction vessel a mixture comprising the halogen adamantane of formula III, 5-20 equivalents of glacial acetic acid and 3-10 equivalents of concentrated sulfuric acid, to provide a reaction mixture, (b2) introducing into the reaction mixture 5-10 equivalents of acetonitrile to provide a reacted mixture, and (c) isolating the acetamido adamantane of formula II formed in step (b1) or (b2) from the reacted mixture, wherein a reaction temperature of 50° C.-90° C. is maintained during introduction of sulfuric acid or of acetonitrile in step (b1) or (b2).