Patent ID: 6995263

Claim:
A Compound of the formula wherein R 1 is hydrogen or C 1-7 -alkyl; R 2 and R 3 independently from each other are hydrogen or C 1-7 -alkyl; R 4 and R 5 are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl or fluoro-C 1-7 -alkyl; R 4′ and R 5′ together form a double bond, or R 4′ and R 5′ are hydrogen; R 6 , R 7 , R 8 and R 9 are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 -alkyl, cyano-C 1-7 -alkyl or cyano; and one of R 6 , R 7 and R 8 is wherein X is S, O, NR 10 , R 10 is hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl; R 11 and R 12 are independently from each other hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl or fluoro; Y 1 , Y 2 , Y 3 and Y 4 are N or C—R 13 and 1 or 2 of Y 1 , Y 2 , Y 3 and Y 4 are N and the other ones are C—R 13 ; R 13 is selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, C 3-7 -cycloalkyl-C 1-7 -alkyl, fluoro-C 1-7 -alkyl, C 1-7 -alkoxy-C 1-7 -alkyl, hydroxy-C 1-7 -alkyl, C 1-7 -alkylthio-C 1-7 -alkyl, carboxy-C 1-7 -alkoxy-C 1-7 -alkyl, carboxy, carboxy-C 1-7 -alkyl, mono- or di-C 1-7 -alkyl-amino-C 1-7 -alkyl, C 1-7 -alkanoyl-C 1-7 -alkyl, C 2-7 -alkenyl, and C 2-7 -alkinyl; R 14 is aryl or heteroaryl; n is 0, 1 or 2; and pharmaceutically acceptable salts and/or esters thereof.