Patent ID: 8513248

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: A is hydrogen, C 1-4 alkyl, C 3-6 cycloalkyl, C 1-3 alkoxy, C 1-3 alkoxy C 1-4 alkyl, C 1-2 fluoroalkyl, halogen, NR 6 R 7 , Het, or phenyl wherein said phenyl is optionally substituted by one, two or three substituents independently being fluorine, chlorine, C 1-3 alkyl, OH, methoxy or deuterium; wherein Het is: i) a 6-membered heteroaromatic monocyclic ring containing one, two or three ring-nitrogen atoms, or ii) a 5-membered heteroaromatic monocyclic ring containing one, two or three ring heteroatoms independently being N, O or S, wherein no more than one of the 5-membered ring heteroatoms is O or S; or iii) a 9 or 10-membered heteroaromatic bicyclic ring containing one, two or three ring nitrogen atoms; and wherein Het is optionally substituted with one or two substituents independently being C 1-3 alkyl, fluorine, chlorine, OH, methoxy or deuterium; and wherein: R 1 is hydrogen, chlorine, fluorine, bromine, C 1 fluoroalkyl, cyano or C 1-3 alkyl; R 2 is hydrogen, fluorine, chlorine, bromine, C 1 fluoroalkyl, cyano or C 1-3 alkyl, R 3 is hydrogen, fluorine, chlorine or C 1-3 alkyl, R 4 is hydrogen; R 5 is hydrogen, fluorine, chlorine or methyl; R 6 and R 7 independently are hydrogen or C 1-3 alkyl; or R 6 and R 7 are taken together and are —(CH 2 ) 2 —O—(CH 2 ) 2 —, —(CH 2 ) 2 —O—(CH 2 ) 3 —, or —(CH 2 ) n 1 — wherein n 1 is 3, 4, 5 or 6; and R 14 is hydrogen, C 1-6 alkyl, C 1-2 fluoroalkyl, C 3-6 cycloalkyl, halogen, or phenyl wherein said phenyl is optionally substituted by one or two substituents independently being fluorine, chlorine, methyl, —CF 3 or methoxy; wherein, when A is hydrogen, C 1-4 alkyl, C 1-3 alkoxy, C 1-3 alkoxy C 1-4 alkyl, C 1-2 fluoroalkyl, halogen or NR 6 R 7 , then R 1 is chlorine, fluorine, bromine, C 1 fluoroalkyl, cyano or C 1-3 alkyl, and at least one of R 2 and R 3 is other than hydrogen; and when A is Het or optionally substituted phenyl, then R 1 is hydrogen, chlorine, fluorine, bromine, C 1 fluoroalkyl, cyano or C 1-3 alkyl, at least one of R 1 , R 2 and R 3 is other than hydrogen, and R 14 is hydrogen, C 1-6 alkyl, C 1-2 fluoroalkyl, C 3-6 cycloalkyl or halogen; and wherein, when R 5 is fluorine, chlorine or methyl, then R 1 is chlorine, fluorine, C 1 fluoroalkyl or methyl and R 2 is hydrogen.