Patent ID: 7599055

Claim:
An interrogation system comprising: a tunable laser that has a tuning range wherein an optical beam is emitted therefrom which has a predetermined sequence of distinct wavelengths over a predetermined time period; illumination optics that converts the optical beam into one or more interrogation beams which illuminate one or more biosensors; imaging optics that collects an image from the illuminated one or more biosensors; a 2-D imaging device that obtains a sequence of the collected images each of which corresponds with one of the distinct wavelengths of the optical beam emitted from said tunable laser; and a data processing device that receives the collected images and processes the collected images to: determine whether or not there was a biochemical interaction on each of the one or more biosensors; locate sensor region(s) and/or reference region(s) on each of the one or more biosensors; remove defect regions on each of the one or more biosensors; and/or calibrate a uniformity of surface chemistry and target molecule immobilizations on each of the one or more biosensors.