Patent ID: 7547717

Claim:
A compound of formula (I) or pharmaceutical salt thereof wherein, R 3 is Ar 1 or Ar 1 —X—Y wherein, each Ar 1 is cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents; X is NR 4 , C(R 4 ) 2 , or O; Y is C═O or lower alkyl; R 1 is Ar 2 or lower alkyl optionally substituted with Ar 2 ; each Ar 2 is independently cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents; each R 2 is independently selected from (CH 2 ) m C(O)OR 4 , (CH 2 ) m C(O)Ar 3 and (CH 2 ) m C(O)NR 4 R 5 ; each R 4 is independently selected from H and lower alkyl; each R 5 is independently selected from H, lower alkyl and (CH 2 ) p Ar 3 ; m is 1 or 2; n is 2 or 3; p is 0 or 1; each Ar 3 is cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents; each substituent for Ar 1 , Ar 2 and Ar 3 is independently selected from halogen, CN, NO 2 , OR 6 , SR 6 , S(O) 2 OR 6 , NR 6 R 7 , cycloalkyl, C 1 -C 2 perfluoroalkyl, C 1 -C 2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR 6 , C(O)NR 6 R 7 , OC(O)NR 6 R 7 , NR 6 C(O)NR 6 R 7 , C(NR 6 )NR 6 R 7 , NR 6 C(NR 7 )NR 6 R 7 , S(O) 2 NR 6 R 7 , R 8 , C(O)R 8 , NR 6 C(O)R 8 , S(O)R 8 and S(O) 2 R 8 ; each R 6 is independently selected from hydrogen and lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino and C 3 -C 6 cycloalkyl; each R 7 is independently selected from hydrogen, (CH 2 ) q Ar 4 and lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino and C 3 -C 6 cycloalkyl; each R 8 is independently selected from (CH 2 ) q Ar 4 and lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino and C 3 -C 6 cycloalkyl each Ar 4 is independently selected from C 3 -C 6 cycloalkyl, aryl and heteroaryl, each optionally substituted with one to three substituents independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino and C 3 -C 6 cycloalkyl; and q is 0 or 1.