Patent ID: 8088818

Claim:
A method for treating a diseases selected from type II diabetes or ischemia, comprising a step of administering to a subject in need thereof an effective amount of a pharmaceutical composition including a catechol-based derivative and a pharmaceutically acceptable carrier, wherein the catechol-based derivative is one of a compound of formula (Ia) or a pharmaceutically acceptable salt thereof: wherein R 2 is selected from the group consisting of H, —OR, —NO 2 , —NH 2 , and a halogen; R in the —OR is one selected from the group consisting of H, (C 1 -C 6 )alkyl, (CH 2 ) n Ph and SO 3 − ; R 3 is one of O and S; R 4 is N; X and Y form a structure being one selected from the group consisting of C 2 -C 3 )alkyl, (C 2 -C 3 )alkenyl, (C 2 -C 3 )alkynyl, and —OCH 2 —; R 5 is one selected from the group consisting of H, C 1 -C 15 )alkyl, (CH 2 ) n Ph and Ar, wherein the n is an integer from 1 to 3, and Ar is one selected from the group consisting of: and a heteroaryl group; R 6 is one of H and (C 1 -C 6 ) alkyl; R 7 , R 8 , R 9 are selected from the group consisting of H, —OH, —OCH 3 , —NO 2 , —NH 2 , —NH 3 + , and a halogen; and X − represents one of an organic alkali and an inorganic alkali.