Patent ID: 7989653

Claim:
A process for preparing Compound 2: wherein R 5 and R 6 are each independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, heterocyclic and heteroaryl groups, or R 5 and R 6 , together with the nitrogen to which they are attached, form a 3- to 6-membered heterocyclic compound containing 1-4 heteroatoms, said process comprising: (a) amidating (R)-butynol to form Compound 3: (b) reducing Compound 3 to yield Compound 4: (c) reacting Compound 4 with Compound 6: to produce Compound 2; wherein: said heterocyclic group is a monocyclic ring containing three to eight ring atoms or a polycyclic ring system consisting of 2 rings containing six to sixteen atoms, where each heterocyclic ring contains carbon atoms and at least one heteroatom selected from the group consisting of nitrogen, sulfur and oxygen; and said heteroaryl group is a monocyclic or multicyclic aromatic ring system containing 4 to 14 ring atoms, wherein the atoms in the ring system are carbon and at least one heteroatom selected from the group consisting of nitrogen, sulfur and oxygen.