Patent ID: 7993666

Claim:
A method of treating pain and/or inflammation from sciatica or spondylolisthesis in a patient in need of such treatment, the method comprising locally administering one or more drug depots having a polymer and comprising a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof and a therapeutically effective amount of a glial cell-derived neurotropic factor at or near a target tissue site beneath the skin of the patient to treat sciatic or spondylolisthesis pain and/or inflammation, wherein the one or more drug depots release 0.1 mg/kg/day to about 3 mg/kg/day of the statin at or near the target tissue site and the statin has a particle size distribution of from about 10 micrometers to about 250 micrometers and the polymer has a molecular weight of about 10,000 to about 100,000.