Patent ID: 7307059

Claim:
An isolated, 2 H labeled peptide or protein molecule with its 2 H label derived from 2 H labeled water ( 2 H 2 O), wherein said isolated, 2 H labeled peptide or protein molecule is produced by administering the 2 H 2 O to an individual wherein said 2 H 2 O is labeled with a detectable amount of 2 H, wherein the 2 H is incorporated into the peptide or protein molecule of the individual via metabolic synthesis, and isolating said 2 H labeled peptide or protein molecule wherein the labeled peptide or protein molecule comprises a full length protein or a peptide fragment selected from the group consisting of bone collagen, liver collagen, lung collagen, cardiac collagen, muscle myosin, serum hormone, plasma apoliprotein, serum albumin, clotting factor, immunoglobulin and mitochondrial protein.