Patent ID: 8003628

Claim:
A method of treating a patient who has a disease characterized by bone loss comprising the step of administering to said patient an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis and/or osteoclast function, wherein said inhibitor is a compound having Formula III wherein: R 1 =H, O(NO 2 ), O(CO)CH 3 , OH, O(CO)(CH 2 ) 2 COOH, O(CO)CH 2 Br, O(CO)CH 2 Cl, O(CO)CH 2 N(CH 3 ) 3 , or OC 5 H 9 O; R 2 =CH 2 O(NO 2 ), CHO, CH 2 O(NO 2 ), CN, CH 3 , COOH, CHNOH, CH 2 O(CO)(CH 2 ) 2 COOH, CHN(NH)CONH 2 , CHN(NH)C 6 H 5 , CHN(CH 2 )C 6 H 5 , CH 2 N(CH 2 ) 2 OH, CH 2 NC 6 H 5 , or CHN(NH)CSNH 2 ; R 3 =OH, or H; R 4 =CH 3 ; R 5 =OH or H; R 6 =C 4 H 3 O 2 , N(NHCO)C 6 H 4 Cl, N(NHCO)C 6 H 4 F, COOH, O, COCH 3 , CH(CH 3 )(CH 2 ) 2 COOH, CH(CH 3 )(CH 2 ) 2 COOCH 3 , O(CO)C 6 H 5 , or OH; R 7 =H, O(CO)CH 2 N(CH 3 ) 3 , or O(CO)CH 3 ; R 8 ═OH or H; R 9 =H, O, or OH; and R 10 ═O or H.