Patent ID: 8859564

Claim:
A compound of formula I: wherein (i) L is S or SO 2 ; (ii) R 1 is H or C 1-6 alkyl; (iii) R 2 is H, C 1-6 alkyl wherein said alkyl group is optionally substituted with halo or hydroxy, —C 0-4 alkyl-C 3-8 cycloalkyl optionally substituted with one or more amino, wherein said cycloalkyl optionally contains one or more heteroatom selected from N and O and is optionally substituted with C 1-6 alkyl, haloC 1-6 alkyl, N(R 14 )(R 15 )—C 1-6 alkyl, hydroxyC 1-6 alkyl, arylC 0-6 alkyl, heteroarylC 1-6 alkyl, C 1-6 alkoxyarylC 1-6 alkyl; (iv) R 3 is 1) -D-E-F wherein: D is a single bond, C 1-6 alkylene or arylalkylene, E is a single bond, C 1-4 alkylene, —C 0-4 alkylarylene, wherein the arylene group is optionally substituted with halo, heteroarylene, aminoC 1-6 alkylene, amino, C 3-8 cycloalkylene optionally containing one or more heteroatom selected from N or O, F is haloC 1-6 alkyl, aryl, C 3-8 cycloalkyl optionally containing at least one atom selected from a group consisting of N or O, and optionally substituted with C 1-6 alkyl, heteroaryl optionally substituted with C 1-6 alkyl, halo or haloC 1-6 alkyl, alkoxadiazoly, amino, O-haloC 1-6 alkyl, C 1-6 alkylsulfonyl, —C(O)—R 13 , —N(R 14 )(R 15 ); 2) a haloalkyl substituted heteroarylaklyl; or 3) attached to one of the nitrogens on the pyrazolo portion of Formula I and is a moiety of Formula A wherein X, Y and Z are, independently, N or C, and R 8 , R 9 , R 11 and R 12 are independently H or halogen; and R 10 is C 3-8 cycloalkyl, haloC 1-6 alkyl, aryl, heteroaryl, C 1-6 alkyl sulfonyl, arylcarbonyl alkoxadiazolyl, heteroarylcarbonyl, alkoxycarbonyl, or aminocarbonyl; provided that when X, Y or Z is nitrogen, R 8 , R 9 or R 10 , respectively, is not present; (v) R 4 is selected from: H, C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, aryl or heteroaryl wherein said aryl or heteroaryl is optionally substituted with halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy or another aryl group; (vi) R 13 is —N(R 14 )(R 15 ), C 1-6 alkyl, —OC 1-6 alkyl, haloC 1-6 alkyl, aryl, or heteroaryl; and (vii) R 14 and R 15 are independently H or C 1-6 alkyl, in free or salt form.