Patent ID: 8063229

Claim:
A compound of formula (I), or an isomer or pharmaceutically acceptable salt thereof: wherein, Ar is phenyl substituted with at least one halogen or C 1 -C 4 haloalkyl; R 1 is hydrogen, fluorine or C 1 -C 4 alkyl; R 2 , R 3 and R 4 are each independently hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 3 -C 6 cycloalkyl, C 1 -C 4 alkoxy, nitro, cyano, amino, hydroxy, —NR 5 R 6 , —CONR 5 R 6 , —CH 2 —CO—R 5 , —CH 2 —OCO—R 5 , —CO—R 5 , —COOR 5 , —C(═NR 5 )NHR 7 , —C(═NR 7 )OR 7 , —SO Z R 7 , —NR 5 SO 2 R 7 or aryl C 1 -C 4 alky, the aryl moiety being phenyl or naphtyl unsubstituted or substituted with at least one halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, nitro, cyano, hydroxy or hydroxymethyl, wherein R 4 may represent two or more substituents independently selected from the above-mentioned substituents; X is C 1 -C 4 alkyl, C 2 -C 4 alkenyl or C 2 -C 4 alkynyl unsubstituted or substituted with at least one halogen; O; NR 2 ; CONR 2 ; or Q-P unsaturated or substituted with O or C 1 -C 4 alky; Q being a linker, CO or C 1 -C 4 alkyl, and P being a 5- to 7-membered heterocyclic ring containing at least one nitrogen or oxygen atom; and A, B, D, E and G are each independently nitrogen or carbon fused together to form a phenyl, pyridine, pyrimidine or triazine group, which is optionally fused with X to form a ring, in which R 5 is hydrogen, C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, —COCF 3 , or the aryl C 1 -C 4 alkyl defined for R 2 ; R 6 is hydrogen, —CONH 2 , —COCH 3 , —CN, or —(C 1 -C 4 alkyl)-NH 2 ; R 7 is C 1 -C 4 alkyl, C 3 -C 6 cylcoalkyl, or the aryl C 1 -C 4 alkyl defined for R 2 ; and Z is 0, 1, or 2.