Patent ID: 8038990

Claim:
An isolated bacterium, comprising: Lactococcus lactis PrtP (SEQ ID NO: 2); and at least one protease selected from the group consisting of Lactococcus lactis HtrA (SEQ ID NO: 1), Lactococcus lactis PrtM (SEQ ID NO: 3), Lactococcus lactis CluA (SEQ ID NO: 4), Streptococcus gordonii SspA (SEQ ID NO: 5), Streptococcus mutans Pac (SEQ ID NO: 6), Lactococcus lactis InbA (SEQ ID NO: 7), Lactobacillus johnsonii HtrH-like proteinase (SEQ ID NO: 8), Lactobacillus acidophilus HtrH-like proteinase (SEQ ID NO: 9), and Streptococcus thermophilus exported proteinase (SEQ ID NO: 10), wherein the isolated bacterium is engineered to overexpress Lactococcus lactis PrtP (SEQ ID NO:2) and the at least one protease selected from the group consisting of Lactococcus lactis HtrA (SEQ ID NO: 1), Lactococcus lactis PrtM (SEQ ID NO: 3), Lactococcus lactis CluA (SEQ ID NO: 4), Streptococcus gordonii SspA (SEQ ID NO: 5), Streptococcus mutans Pac (SEQ ID NO: 6), Lactococcus lactis InbA (SEQ ID NO: 7), Lactobacillus johnsonii HtrH-like proteinase (SEQ ID NO: 8), Lactobacillus acidophilus HtrH-like proteinase (SEQ ID NO: 9), and Streptococcus thermophilus exported proteinase (SEQ ID NO: 10), and wherein the isolated bacterium promotes the inhibition or removal of a biofilm.