Patent ID: 7189733

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: a-b is wherein each hydrogen is optionally replaced by a C 1-4 aliphatic group; Z is N; G is a phenyl, naphthyl, or 5–6 membered heteroaryl ring having 1–3 ring heteroatoms selected from nitrogen, sulfur or oxygen, wherein G is optionally substituted by 1–3 R 5 ; Ring A is optionally substituted by 1–3 R 1 ; Ring B is optionally substituted by 1–2 R 6 at a position ortho to the ring nitrogen and is optionally substituted by R 7 at the position meta to the ring nitrogen; each R 1 is independently selected from —R 2 , -T-R 2 , or —V-T-R 2 ; each R 2 is independently selected from C 1-3 aliphatic, hydroxy, —N(R 3 ) 2 , halo, cyano, —OR 4 , —C(O)R 4 , —CO 2 R 4 , —SR 4 , —S(O)R 4 , —S(O) 2 R 4 , —N(R 3 )C(O)R 4 , —N(R 3 )CO 2 R 4 , —N(R 3 )SO 2 R 4 , —C(O)N(R 3 ) 2 , —SO 2 N(R 3 ) 2 , —N(R 3 )C(O)N(R 3 ) 2 , —OC(O)R 4 , phenyl, 5–6 membered heterocyclyl or 5–6 membered heteroaryl; each T is independently a C 1-5 alkylidene that is optionally interrupted by —O—, —C(O)—, —S—, —S(O)—, —S(O) 2 —, or —N(R 3 )—; each V is independently selected from —O—, —S—, —S(O)—, —S(O) 2 —, —C(O)—, —N(R 3 )—, —N(R 3 )C(O)—, or —N(R 3 )C(O) 2 —, —N(R 3 )S(O) 2 —, —C(O)N(R 3 )—, —S(O) 2 N(R 3 )—, —N(R 3 )C(O)N(R 3 )—, or —OC(O)—; each R 3 is independently selected from hydrogen, C 1-6 aliphatic, —C(O)R 4 , —C(O) 2 R 4 , —SO 2 R 4 , or two R 3 on the same nitrogen together with their intervening nitrogen form a 5–6 membered heterocyclyl or heteroaryl ring having 1–3 ring heteroatoms selected from nitrogen, oxygen or sulfur; each R 4 is independently selected from a C 1-6 aliphatic group, phenyl or a 5–6 membered heteroaryl or heterocyclyl having 1–3 ring heteroatoms selected from nitrogen, oxygen or sulfur; each R 5 is independently selected from C 1-6 aliphatic, halo, —OH, —N(R 3 ) 2 , cyano, —OR 4 , —C(O)R 4 , —CO 2 R 4 , —SR 4 , —S(O)R 4 , —S(O) 2 R 4 , —N(R 3 )C(O)R 4 , —N(R 3 )CO 2 R 4 , —N(R 3 )SO 2 R 4 , —C(O)N(R 3 ) 2 , —SO 2 N(R 3 ) 2 , —N(R 3 )C(O)N(R 3 ) 2 , —OC(O)R 4 , —OC(O)N(R 3 ) 2 , phenyl, 5–6 membered heterocyclyl or 5–6 membered heteroaryl, or two adjacent R 5 on a phenyl, naphthyl or heteroaryl ring are taken together with their intervening atoms to form a 5–6 membered fused ring having 0–2 heteroatoms selected from nitrogen, oxygen or sulfur; each R 6 is independently selected from a C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 mono- or dialkylamino; and R 7 is selected halo, —OH, —N(R 3 ) 2 , cyano, —OR 4 , —C(O)R 4 , —CO 2 R 4 , —SR 4 , —S(O)R 4 , —S(O) 2 R 4 , —N(R 3 )C(O)R 4 , —N(R 3 )CO 2 R 4 , —N(R 3 )SO 2 R 4 , —C(O)N(R 3 ) 2 , —SO 2 N(R 3 ) 2 , —N(R 3 )C(O)N(R 3 ) 2 , or —OC(O)R 4 .