Patent ID: 7553942

Claim:
A method for labeling synthesis, comprising: (a) providing a UV reactor assembly comprising a high pressure reaction chamber, a UV lamp and a concave mirror, wherein the high pressure reaction chamber comprises a window facing the concave mirror, a liquid inlet and a gas inlet in a bottom surface thereof, (b) reacting a solution of weakly nucleophilic amine with a metal base to improve the reactivity of said weakly nucleophilic amine, (c) adding a solution of akyl iodides to the solution of step (b) to give a solution to be labeled, (d) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber of the UV reactor assembly via the gas inlet, (e) introducing at high pressure said reagent into the reaction chamber via the liquid inlet, (f) turning on the UV lamp and waiting for a predetermined time while the labeling synthesis occur, and (g) collecting the labeled amide from the reaction chamber.