Patent ID: 8703923

Claim:
A process for preparing Fondaparinux sodium comprising: (i) deprotecting and then THP protecting a levulinate pentamer of the formula: where R 2 is Ac or Bz to obtain a THP pentamer of the formula: (ii) hydrolyzing a THP pentamer of the formula: where R 2 is Ac or Bz to obtain a hydrolyzed pentamer of the formula: (iii) sulfating a hydrolyzed pentamer of the formula: to obtain an O-sulfated pentamer of the formula: (iv) hydrogenating an O-sulfated pentamer of the formula: to obtain a hydrogenated pentamer of the formula: (v) N-sulfating a hydrogenated pentamer of the formula: to obtain Fondaparinux-THP of the formula: (vi) deprotecting the Fondaparinux-THP to obtain Fondaparinux sodium.