Patent ID: 8486912

Claim:
A method of decreasing expression of a transcription factor gene product from the Maf family, also known as protooncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, (MAFB in a subject having a cancer and/or myeloproliferative disorder associated with an overexpression of a MAFB gene product, comprising administering an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof to the subject sufficient to decrease expression of the MAFB gene product in the subject, wherein the cancer and/or myeloproliferative disorder is selected from the group consisting of: acute myeloid leukemia (AML), acute megakaryoblastic leukemia (AMKL), multiple myeloma (MM), and chronic myelogenous leukemia (CML).