Patent ID: 7388012

Claim:
A compound represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein: J is —NR 1 R 2 or —OR 1 ; A is aryl, heteroaryl, cycloC 3-10 alkyl, heterocyclyl, cycloC 3-10 alkenyl, or heterocycloalkenyl, each of which is optionally substituted by 1-5 independent R 4 substituents; R 1 is C 1-6 alkyl, aryl, heteroaryl, cycloC 3-10 alkyl, heterocyclyl, cycloC 3-10 alkenyl, heterocycloalkenyl, C 2-6 alkenyl, C 2-6 alkynyl, each of which is optionally substituted by 1-5 independent R 41 substituents; R 2 is C 0-6 alkyl, aryl, heteroaryl, cycloC 3-10 alkyl, heterocyclyl, cycloC 3-10 alkenyl, heterocycloalkenyl, C 2-6 alkenyl, C 2-6 alkynyl, each of which is optionally substituted by 1-5 independent R 42 substituents; or R 1 and R 2 , taken together with the N atom to which they are attached, form a heterocyclyl, heterocylcoalkenyl, or heteroaryl, each of which is optionally substituted with 1-4 independent R 41 substituents; provided R 1 and R 2 taken together with the N atom to which they are attached do not form a pyrazolyl; R 3 is C 0-6 alkyl, halogen, C 1-6 alkyl, or haloalkyl; R 4 , R 41 , and R 42 each independently is C 0-6 alkyl, cycloC 3-10 alkyl, oxo, halogen, haloalkyl, cyanoC 0-6 alkyl, nitroC 0-6 alkyl, hydroxyC 0-6 alkyl, C 0-6 alkylaminoC 0-6 alkyl, aminoC 1-6 alkylamino, acylaminoC 0-6 alkylamino, acylC 0-6 alkyl, substituted acyl, guanidinoC 0-6 alkyl, hydroxyiminoC 0-6 alkyl, acylaminoC 0-6 alkyl, substituted acylamino, acyloxyC 0-6 alkyl, substituted acyloxy, arC 0-6 alkyl, substituted arC 0-6 alkyl, heteroarylC 0-6 alkyl, substituted heteroarylC 0-6 alkyl, heterocyclylC 0-6 alkyl, cyanoaminoC 0-6 alkyl, C 0-6 alkylhydrazino, heterocyclylamino, arC 0-6 alkylhydrazino, alkylsulfonylC 0-6 alkyl, arC 0-6 alkylsulfonylC 0-6 alkyl, alkylsulfinylC 0-6 alkyl, alkylsulfonamidoC 0-6 alkyl, arC 0-6 alkylsulfonamidoC 0-6 alkyl, aminoC 0-6 alkylsulfonyl, C 0-6 alkylaminosulfonyl, acylC 1-6 alkylsulfonyl, heterocyclylsulfonyl, aminoC 0-6 alkylsulfinyl, acylC 1-6 alkylsulfinyl, silyl, siloxy, alkenoxy, alkynoxy, C 2-6 alkenyl, acylC 2-6 alkenyl, C 2-6 alkynyl, acylC 2-6 alkynyl, hydroxyC 2-6 alkynyl, aminoC 2-6 alkynyl, C 1-6 alkoxyC 0-6 alkyl, C 1-6 alkylthioC 0-6 alkyl, hydroxyC 1-6 alkoxyC 0-6 alkyl, hydroxyC 1-6 alkylthioC 0-6 alkyl, acylC 1-6 alkoxyC 0-6 alkyl, acylC 1-6 alkylthioC 0-6 alkyl, C 0-6 alkylaminoC 1-6 alkoxyC 0-6 alkyl, C 0-6 alkylaminoC 1-6 alkylthioC 0-6 alkyl, acylaminoC 1-6 alkoxyC 0-6 alkyl, acylaminoC 1-6 alkylthioC 0-6 alkyl, arC 0-6 alkylaminoC 0-6 alkyl, arC 0-6 alkylthioC 0-6 alkyl, arC 0-6 alkoxyC 0-6 alkyl, arC 0-6 alkylamino, arC 0-6 alkylaminoC 0-6 alkyl, arC 0-6 alkylthio, substituted arC 0-6 alkoxy, substituted arC 0-6 alkylthio,or substituted arC 0-6 alkoxy; and provided that the compound is not N′-(tert-butyl)-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carbohydrazide or N-morpholin-4-yl-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide.