Patent ID: 8188284

Claim:
A compound of formula (I) wherein A is —CH 2 — or —O—, R 1 is 5-membered heteroaryl, —C(═NR a )—Ar 1 , —NR b —Ar 1 , —C(O)—NH—Ar 1 , —NH—C(O)—Ar 1 , —NH—S(O) 2 —Ar 1 , —NH—CH 2 —Ar 1 , —O—CH 2 —Ar 1 , —CH 2 —NH—C(O)—Ar 1 , —C(O)—NH—CH 2 —Ar 1 , —CH 2 —NH—CH 2 —Ar 1 , —NH—S(O) 2 —NR c —Ar 1 , —NR d —C(O)—NR e —Ar 1 , —NH—C(O)—CH 2 —Ar 1 , —NH—C(O)—O—Ar 1 , —NH—C(O)—NH—CHR f —Ar 1 , —NH—C(═NR a )—NH—CH 2 —Ar 1 , —NH—(CH 2 ) 3 —Ar 1 , or —NH—C(S)—NH—C(O)—Ar 1 , R a is H, OH, or alkyl, R b , R c , R d , R e , and R f are each independently H, alkyl, or allyl, Ar 1 is phenyl or 5- to 10-membered monocyclic or bicyclic heteroaryl, each of which is unsubstituted or substituted by one or more halo, CN, NO 2 , NH 2 , OH, alkyl, haloalkyl, hydroxyalkyl, cyanoalkyl, cycloalkyl, -alkylene-cycloalkyl, -alkylene-O-alkyl, alkoxy, haloalkoxy, —S(O) 2 -alkyl, —S(O) 2 -cycloalkyl, —SF 5 , or 5- to 6-membered heterocycloalkyl, wherein cycloalkyl or heterocycloalkyl are each unsubstituted or substituted independently by one or more oxo, halo, alkyl, hydroxy, hydroxyalkyl, haloalkyl or alkyoxy, R 2 , R 3 , R 4 and R 5 are independently selected from H, halo, alkyl and alkoxy; or a pharmaceutically acceptable salt thereof.