Patent ID: 8383670

Claim:
A compound of Formula (I): wherein: A is phenyl or benzofuranyl, wherein phenyl and benzofuranyl are each optionally substituted with at least one R; or A is phenyl substituted with two R groups on adjacent carbon atoms wherein the two R groups and the carbon atoms to which they are attached form a C 4 -C 8 cycloalkyl or C 3 -C 8 heterocycloalkyl; R is selected from F, Cl, Br, I, —CN, —NO 2 , —CF 3 , —OH, —OR 3 , —OCF 3 , —C≡CH, —C≡CR 3 , C 1 -C 6 alkylenealkynyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 6 heterocycloalkyl, phenyl, —NHS(═O) 2 R 3 , S(═O) 2 N(R 4 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 3 , —S(═O) 2 NHC(═O)R 4 , N(R 4 ) 2 , —N(R 4 )C(═O)R 3 , —CO 2 R 4 , —C(═O)R 3 , —OC(═O)R 3 , —C(═O)N(R 4 ) 2 , —SR 3 , —S(═O)R 3 , and —S(═O) 2 R 3 ; J is a bond, —C(═O), N(R 4 ), ——S, or C 1 -C 6 alkylene, wherein C 1 -C 6 alkylene is optionally substituted with at least one R; R 1 is CO 2 R 2 , wherein R 2 is hydrogen; Z is O; X is W-L-phenyl, W-L-B, W-L-D, or D wherein phenyl, B, and D are each optionally substituted with at least one R; W is NR 2 , O or a bond; L is methylene, ethylene substituted with at least one R, C 3 -C 6 alkylene, C 2 -C 6 alkynylene, C 1 -C 6 heteroalkylene, C 3 -C 6 cycloalkylene, or C 2 -C 6 heterocycloalkylene, wherein methylene, C 3 -C 6 alkylene, C 2 -C 6 alkynylene, C 1 -C 6 heteroalkylene, C 3 -C 6 cycloalkylene, and C 2 -C 6 heterocycloalkylene is optionally substituted with at least one R; B is selected from furan, thiophene, pyrrole, pyridine, oxazole, thiazole, imidazole, thiadiazole, isoxazole, isothiazole, pyrazole, pyridazine, pyrimidine, pyrazine, oxadiazole, thiadiazole, triazole, indole, benzoxazole, benzothiazole, benzimidazole, benzoxadiazole, benzothiadiazoie, benzotriazole, pyrazolopyridine, imidazopyridine, pyrrolopyridine, pyrrolopyrimidine, indolizine, purine, furopyridine, thienopyridine, furopyrrole, furofuran, thienofuran, 1,4-dihydropyrrolopyrrole, thienopyrrole, thienothiophene, quinoline, isoquinoline, furopyrazole, thienopyrazole, and 1,6-dihydropyrrolopyrazole; D is C 3 -C 10 cycloalkyl or C 2 -C 9 heterocycloalkyl; each R 3 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; each R 4 is independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; or a pharmaceutically acceptable salt thereof.