Patent ID: 7335648

Claim:
A method of treating diseases or conditions associated with increased platelet aggregation, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula III, or a pharmaceutically acceptable hydrate, solvate or salt thereof, wherein said amount is effective to inhibit platelet aggregation: wherein R a =R c =H; R b is selected from the group consisting of: hydrogen, C 1-8 alkyl, C 1-8 alkenyl, C 1-8 alkynyl, C 3-7 cycloalkyl, C 4-7 cycloalkenyl, aralkyl, and aryl, where all rings or chains optionally bear one or more substituents; R d and R d′ are independently selected from the group consisting of: H, C 1-8 alkyl, C 1-8 alkenyl, C 1-8 alkynyl, and C 3-7 cycloalkyl; R e is absent; R f and R g are independantly selected from the group consisting of: —H, halogen, C 1-8 alkyl, C 1-8 alkenyl, C 1-8 alkynyl, and C 3-7 cycloalkyl; R h is H, alkyl, aryl, or aralkyl; G is O; J is carbon; A 1 is O; D is O; X 1 is selected from the group consisting of: N and C-M; and M is independently selected from the group consisting of: —H, halogen, —CF 3 , C 1-8 alkyl, cyano, C 1-8 alkenyl, C 1-8 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkenyl, —OH, saturated or unsaturated C 1-6 alkoxy, amino, —N-substituted amino, and N,N-disubstituted amino.