Patent ID: 8114962

Claim:
An isolated target binding assembly (TBA) comprising a first and a second nucleic acid recognition unit, wherein: said first nucleic acid recognition unit is capable of binding with specificity to a first target nucleotide sequence contained within a target polynucleotide; said second nucleic acid recognition unit is capable of binding with specificity to a second target nucleotide sequence contained within a target polynucleotide; said nucleic acid recognition units are polypeptides and are the same or different; and wherein said TBA comprises a sequence selected from the group consisting of: A. I+II+III; B. IV+V+III; and C. IV+III; wherein I indicates any of SEQ ID NOS:85-92; II indicates Met Ser, linked to any of SEQ ID NOS:104-106, each of which is linked to SEQ ID NO:99; III indicates SEQ ID NO:100 linked to any of SEQ ID NOS:75-84 or 94-98; SEQ ID NO: 101 linked to either SEQ ID NO:74 or SEQ ID NO:93; or SEQ ID NO:102 linked to SEQ ID NO:74 or SEQ ID NO:93; or any of SEQ ID NOS:72, 103, 73, or 63-71; IV indicates any of SEQ ID NOS. 104-106; and V indicates SEQ ID NO:99.