Patent ID: 6858610

Claim:
A compound having potassium channel inhibitory activity of formula (I), or a pharmaceutically acceptable salt thereof: wherein, A, B, and D are selected from a substituted carbon atom, a nitrogen atom or N→O, wherein at least one of A, B, and D is a substituted carbon atom, wherein at least one of A, B and D is a nitrogen atom or N→O and at most only one of A, B and D is N→O; E and G are each hydrogen, or E and G taken together form a bond; R 1 is selected from hydrogen, alkyl, carbocycloalkyl, aryl, heterocyclo, heteroaryl, alkoxy, aryloxy, and substituted amino; Y is selected from a bond, alkyl, carbocycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and heterocyclo; X is one of C═O, C═S or SO 2 ; R 2 and R 3 are independently selected from hydrogen (H), alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, (heteroaryl)alkyl, aminoalkyl; substituted aminoalkyl, carboxyalkyl, alkoxyalkanoyl, aminoalkanoyl, substituted aminoalkanoyl, alkanoylamidoalkyl, alkanoyl(substituted amido)alkyl, aroylamidoalkyl, aroyl(substituted amido)alkyl, heterocyclocarbonylamidoalkyl, heterocyclocarbonyl(substituted amido)alkyl, heteroaroylamidoalkyl, and heteroaroyl(substituted amido)alkyl; R 4 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heteroaryl and heterocyclo; R 5 and R 6 are each independently selected from hydrogen and alkyl; R 7 is independently selected from hydrogen, alkyl, hydroxy, alkoxy, amino, substituted amino, nitro, cyano, halo, carboxy, alkoxycarbonyl, aminocarbonyl, substituted aminocarbonyl and n is 1, 2 or 3; Z is selected from hydrogen, alkyl, hydroxy, SH, alkoxy, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted)amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido, and heterocyclocarbonyl(alkyl substituted)amido; with the provisos that i) when R 4 is aryl, then R 4 is not a 3,4-dialkoxy phenyl, or a 3-cycloalkylalkoxy, 4-alkoxy phenyl.