Patent ID: 6852712

Claim:
A method of inhibiting PDGF tyrosine kinase activity comprising contacting a compound of formula I: wherein X is L 1 or L 2 Z 2 ; L 1 is (CR 3a R 3b ) r H or (CR 3a R 3b ) m —Z 3 —(CR 3′a R 3′b ) n H; L 2 is (CR 3a R 3b ) p —Z 4 —(CR 3′a R 3′b ) q or ethenyl; Z 1 is N; Z 2 is cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocyclyl, substituted heterocyclyl, heterocyclenyl, or substituted heterocyclenyl; Z 3 is O, NR 4 , S, SO, or SO 2 ; Z 4 is O, NR 4 , S, SO, SO 2 , or a bond; m is 0 or 1; n is 2 or 3, and n+m=2 or 3; p and q are independently 0, 1, 2, 3 or 4, and p+q=0, 1, 2, 3 or 4 when Z 4 is a bond, and p+q=0, 1, 2 or 3 when Z 4 is other than a bond; r is 2, 3 or 4; R 1a and R 1b are independently alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R 5 R 6 N— or acylR 5 N—, or one of R 1a and R 1b is hydrogen or halo and the other is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R 5 R 6 N— or acylR 5 N—; R 1c is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, halo, cyano, R 5 R 6 N— or acylR 5 N—; R 3a , R 3b , R 3′a and R 3′b are independently hydrogen or alkyl; R 4 is hydrogen, alkyl or acyl; and R 5 and R 6 are independently hydrogen or alkyl, or R 5 and R 6 taken together with the nitrogen atom to which R 5 and R 6 are attached form azaheterocyclyl, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or a pharmaceutically acceptable salt thereof; with a composition containing a PDGF tyrosine kinase.