Patent ID: 7521447

Claim:
A compound of the Formula wherein Ar 1 is aryl or heteroaryl, each of which may be substituted or unsubstituted; A is H, OH, an amine protecting group, Z n -NR 2 R 3 , Z n -NR 2 (C═O)R 2 , Z n -SO 2 R 2 , Z n -SOR 2 , Z n -SR 2 , Z n -OR 2 , Z n -(C═O)R 2 , Z n -(C═O)OR 2 , Z n -O—(C═O)R 2 , alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n -Ar 1 , wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalky, or Z n -Ar 1 may be substituted or unsubstituted; Z is alkylene of from 1 to 4 carbons, or alkenylene or alkynylene each of from 2 to 4 carbons, wherein said alkylene, alkenylene, or alkynylene may be substituted or unsubstituted; R 2 and R 3 are independently H, OH, an amine protecting group, an alcohol protecting group, an acid protecting group, a sulfur protecting group, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n -Ar 1 , wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n -Ar 1 may be substituted or unsubstituted, or R 2 together with R 3 and N forms a saturated or partially unsaturated heterocycle ring of 1 or more heteroatoms in said ring, wherein said heterocycle may be substituted or unsubstituted and wherein said heterocycle may be fused to an aromatic ring; B is H, NH 2 , or substituted or unsubstituted methyl; E is Z n -NR 2 R 3 , Z n -(C═O)R 4 , Z n -(C═O)R 5 , Z n -NR 5 (C═O)R 5 , Z n -O(C═O)R 5 , Z n -OR 5 , Z n -SO 2 R 5 , Z n -SOR 5 , Z n -SR 5 , or Z n -NH(C═O)NHR 5 ; R 4 is NH(CHR 6 )(CH 2 ) m OR 5 where m is an integer from 1 to 4, or NR 2 R 3 ; R 5 is H, OH, an amine protecting group, an alcohol protecting group, an acid protecting group, a sulfur protecting group, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n -Ar 1 , wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Z n -cycloalkyl, Z n -heterocycloalkyl, or Z n -Ar 1 may be substituted or unsubstituted; R 6 is a natural amino acid side chain, Z n -NR 2 R 3 , Z n -OR 5 , Z n -SO 2 R 5 , Z n -SOR 5 , or Z n -SR 5 ; and n is 0 or 1, or a resolved enantiomer, diastereomer or pharmaceutically acceptable salt thereof.