Patent ID: 7737111

Claim:
A composition of matter having the formula (X 1 ) a —V 1 —(X 2 ) b and multimers thereof, wherein: V 1 is an Fc domain; X 1 and X 2 are each independently selected from -(L 1 ) c -P 1 -(L 2 ) d -P 2 , -(L 1 ) c -P 1 -(L 2 ) d P 2 -(L 3 ) e P 3 , -(L 1 ) c -P 1 -(L 2 ) d -P 2 -(L 3 ) e -P 3 -(L 4 ) f -P 4 ; one or more of P 1 , P 2 , P 3 , and P 4 each independently comprise a TALL-1 modulating domain comprising the amino acid sequence f 1 -f 2 -f 3 -Lys-f 5 -Asp-f 7 Leu-f 9 -f 10 -Gln-f 12 -f 13 -f 14 (SEQ. ID. NO:109) and having a maximum length of 40 amino acids; f 1 and f 2 are absent or are amino acid residues; f 3 is Cys; f 5 is Trp, Tyr, or Phe; f 7 is an amino acid residue; f 9 is Thr or Ile; f 10 is Lys, Arg, or His; f 12 is a neutral hydrophobic residue, or a basic residue; f 13 is Val; and f 14 is Cys; L 1 , L 2 , L 3 , and L 4 are each independently linkers, wherein each linker is selected from a peptide linker, alkyl linker, or a derivative thereof; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1.