Patent ID: 8618062

Claim:
A polypeptide for inhibiting growth of a cancer cell, the polypeptide comprising an amino acid sequence selected from the group consisting of 1) an amino acid sequence defining a binding domain of a Î² integrin subunit for ERK2 MAP kinase, said binding domain comprising an intervening, centrally located amino acid linker sequence that links opposite terminal end amino acid sequence regions of the binding domain together and is non-essential for binding of the MAP kinase to the binding domain, the amino acid sequence defining the binding domain being selected from the group consisting of RSKAKWQTGTNPLYR (SEQ ID NO. 2), RARAKWDTANNPLYK (SEQ ID NO. 22) and RSRARYEMASNPLYR (SEQ ID NO. 23); and 2) an amino acid sequence defining the binding domain as specified in 1) wherein the linker sequence of the binding domain is deleted such that the opposite terminal end amino acid sequence regions of the binding domain remain and are contiguous with one another in the polypeptide, and the polypeptide is from 10 to 15 amino acids in length.