Patent ID: 7893039

Claim:
A compound having the following formula I: or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein: Q 1 is azido or —NR 10 R 11 ; Q 2 is —NR 10 R 12 ; each Q 3 and Q 4 is —OR 7 ; Q 5 is H, halogen, cyano, azido, —OR 8 , —NR 2 R 3 , a protected amino group or a nitrogen containing heterocyclic radical which optionally includes one or more additional heteroatoms selected from N, O and S wherein the heterocyclic radical is covalently linked through said nitrogen atom; each R 1 is, independently, H or a hydroxyl protecting group; each R 2 is, independently, H, an amino protecting group, C 1 -C 12 alkyl or substituted C 1 -C 12 alkyl; each R 3 is, independently, H, an amino protecting group, cyano, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl or —(CH 2 ) n -(L 1 ) m -(CH 2 ) nn -E 1 ; each R 6 is, independently, H or an amino protecting group; each R 7 is, independently, H, a hydroxyl protecting group or or —(CH 2 ) n -(L 1 ) m —(CH 2 ) nn -E 1 ; R 8 is H, a hydroxyl protecting group, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl or or —(CH 2 ) n -(L 1 ) m -(CH 2 ) nn -E 1 ; each R 10 is, independently, H, C 1 -C 12 alkyl or substituted C 1 -C 12 alkyl; each R 11 is, independently, cyano, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl or —(CH 2 ) n -(L 1 ) m -(CH 2 ) nn -E 1 ; and R 12 is a group having the following formula III: each L 1 is, independently, S, O or NJ 1 ; L 2 is CH or N; each n is, independently, an integer from 1 to 8; each m is, independently, 0 or 1; each nn is, independently, 0 or an integer from 1 to 8; mm is 1 or 2; each E 1 is, independently, H, hydroxyl, halogen, cyano, —NJ 1 J 2 , C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 5 -C 20 aryl, substituted C 5 -C 20 aryl, heteroaryl, substituted heteroaryl, a heterocyclic radical, a substituted heterocyclic radical or a substituted or unsubstituted mono or poly cyclic structure that is unsaturated, partially saturated or fully saturated and optionally includes one or more heteroatoms selected from O, N and S; each J 1 and J 2 is, independently, H, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 5 -C 20 aryl, substituted C 5 -C 20 aryl, —C(═O)—X, a heterocyclic radical or a substituted heterocyclic radical; each X is, independently, H, C 1 -C 12 alkyl or substituted C 1 -C 12 alkyl; each Z 1 and Z 2 is, independently, H, hydroxyl or a protected hydroxyl; and Z 3 is a group having the following formula IV: wherein when Q 2 is —N(H)C(═O)C(H)(OH)CH 2 CH 2 NH 2 then Q 1 is other than —N(H)CH 3 or —N(H)CH 2 CH 3 and Q 5 is other than —N(H)C(═NH)NH 2 or —N(H)CH═NH 2 .