Patent ID: 8741905

Claim:
A compound of Formula I or a prodrug or metabolite thereof; wherein, each X 1 and X 3 is independently —O— or —S—; each X 4 , X 5 and X 6 is independently —CH or —N—; each X 2 , Y 1 and Y 2 is independently —NR 10 , —S— or —O—; Cy 1 is an optionally substituted aryl group; Cy 2 is an optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl or optionally substituted aryl containing one, two or three rings; R 1 is hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl; each R 2 , R 3 , R 4 and R 5 is independently selected from absent, hydrogen, halogen, —OR 10 , —SR 10 , —NR 10 R 11 , —C(O)R 10 , —C(O)OR 10 , —C(O)NR 10 R 11 , —N(R 10 )C(O)R 11 , —CF 3 , —CN, —NO 2 , —N 3 , acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl; G 1 is —N(R 10 )C(O)—, —N(R 10 )C(S)—, —N(R 10 )S(O) 2 —, —N(R 10 )S(O) 2 —[C(R 10 )(R 11 )] W —, —N(R— 10 )C(O)—[C(R 10 )(R 11 )] W —, —N(R 10 )C(S)—[C(R 10 )(R 11 )] W —, —N(R 10 )C(O)N(R 11 )—, —N(R— 10 )C(S)N(R 11 )—, —C(O)O— or —C(O)O—[C(R 10 )(R 11 )] W —; each n and m is independently selected from 0, 1, 2 or 3; each v and w is independently selected from 0, 1, 2, 3, 4, 5 or 6; each R 10 , R 11 , R 12 , R 13 and R 14 is independently absent, hydrogen, halogen, OH, —SH, —NH 2 , —CF 3 , —CN, —NO 2 , —N 3 , —C(O)OH, —C(O)NH 2 , acyl, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two of R 10 , R 11 , R 12 , R 13 and R 14 together with the atoms to which they are attached and any intervening atoms may form an additional optionally substituted, 3, 4, 5, 6 or 7 membered ring.