Patent ID: 7459564

Claim:
A compound of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein: A is cyclohexyl substituted with 0-1 R 1 and 0-3 R 2 ; provided that A is other than cyclohexyl substituted with CN; ring B is phenyl optionally further substituted with 0-3 R 4 ; Z is —CHR 11 —; L is —C(O)NR 10 —; R 1 is, independently at each occurrence, H, —NH 2 , —NH(C 1-3 alkyl), —(CH 2 ) r NR 7 R 8 ,—CH(C 1-4 alkyl)NH 2 , —CH(C 1-4 alkyl) 2 NH 2 , —N(C 1-3 alkyl) 2 , —C(═NH)NH 2 , —C(O)NH 2 , —CH 2 NH 2 , —CH 2 NH(C 1-3 alkyl), —CH 2 N(C 1-3 alkyl) 2 ,—CH 2 CH 2 NH 2 , —CH 2 CH 2 NH(C 1-3 alkyl), —CH 2 CH 2 N(C 1-3 alkyl) 2 , OCF 3 , CF 3 , OR a , SR a , CN or C 1-6 alkyl; R 2 is, independently at each occurrence, H, ═O, CF 3 , OCF 3 , CHF 2 , CN, NO 2 , OR a , SR a , —NR 7 R 8 , or C 1-6 alkyl; R 3 is a heterocycle selected from: benzisoxazole, indazole, quinoline, tetrahydroquinoline, phthalazine, and quinazoline, wherein said heterocycle is substituted with 0-3 R 3a ; R 3a is, independently at each occurrence, ═O, F, Cl, Br, I, OCF 3 , CF 3 , —(CH 2 ) r CN, NO 2 , —(CH 2 ) r OR 3b , —(CH 2 ) r —SR 3b , —(CH 2 ) r NR 7 R 8 , —C(O)C 1-4 alkyl, —SO 2 NHR 3b , —(CH 2 ) r NR 8 CO 2 R 3b , —(CH 2 ) r S(O) p NR 8 R 9 , —S(O)R 3c , —S(O) 2 R 3c , —(CH 2 ) r CO 2 R 3b , —(CH 2 ) r C(O)NR 8 R 9 , C 1-4 haloalkyl, C 1-4 haloalkyloxy-, or C 1-6 alkyl; R 3b is, independently at each occurrence, H, or C 1-6 alkyl; R 3C is, independently at each occurrence, C 1-6 alkyl R 4 is, independently at each occurrence, H, F, Cl, Br, I, OCF 3 , CF 3 , CN, NO 2 , OR a , SR a , —C(O)R a , —C(O)OR a , —OC(O)R a , —NR 7 R 8 , —C(O)NR 8 R 9 , —NR 8 C(O)R b , —NR 8 C(O)OR b , —S(O)R c , —S(O) 2 R c , or C 1-6 alkyl R 7 is, independently at each occurrence, H, C 1-4 alkyl, —C(O)(C 1-4 alkyl), or —(CH 2 ) n -phenyl; R 8 is, independently at each occurrence, H, C 1-6 alkyl, or —(CH 2 ) n -phenyl; R 9 is, independently at each occurrence, H, C 1-6 alkyl, or —(CH 2 ) n -phenyl; R 10 is, independently at each occurrence, H, or C 1-6 alkyl substituted with 0-2 F; R 11 is —(CH 2 ) s -phenyl substituted with 0-2 R 11b ; R 11b is, independently at each occurrence, H, OR a , SR a , F, Cl, Br, CN, NO 2 , CF 3 , OCF 3 , OCHF 2 , —NR 7 R 8 , —C(O)R a , —C(O)OR a , —C(O)NR 7 R 8 , —CH 2 OR a , —CH 2 NR 7 R 8 , —NR 8 C(O)R b , —S(O) p NR 8 R 9 , —NR 8 S(O) p R c ,—S(O) p R c , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-4 haloalkyl, or C 1-4 haloalkyloxy; R a is, independently at each occurrence, H, CF 3 , C 1-6 alkyl, —(CH 2 ) r —C 3-7 cycloalkyl, or —(CH 2 ) r —C 6-10 aryl; R b is, independently at each occurrence, CF 3 , OH, C 1-4 alkoxy, or C 1-6 alkyl; R c is, independently at each occurrence, CF 3 , or C 1-6 alkyl; r, at each occurrence, is selected from 0, 1, 2, 3, and 4; n, at each occurrence, is selected from 0, 1, 2, 3, and 4; p, at each occurrence, is selected from 0, 1, and 2; and s, at each occurrence, is selected from 1, 2, 3, and 4.