Patent ID: 7718704

Claim:
A compound of Formula I: in which: n is 0, 1 or 2; R 1 is chosen from C 6-10 aryl optionally substituted by a C 3-8 cycloalkyl; wherein any aryl or cycloalkyl group of R 1 can be optionally substituted by one to five radicals selected from the group consisting of halo, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted-C 1-10 alkyl and halo-substituted-C 1-10 alkoxy; R 2 and R 3 are independently chosen from hydrogen, C 1-6 alkyl, halo, hydroxy, C 1-6 alkoxy, halo-substituted C 1-6 alkyl and halo-substituted C 1-6 alkoxy; A is —X 1 C(O)OR 4 wherein X 1 is a bond or C 1-6 alkylene and R 4 is chosen from hydrogen and C 1-6 alkyl; W is methylene; X is C 2-4 alkenylene; wherein one methylene group of X can be replaced with an —O— atom; Y is chosen from C 6-10 aryl and C 5-10 heteroaryl, wherein any aryl or heteroaryl of Y can be optionally substituted with 1 to 3 radicals chosen from halo, hydroxy, nitro, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted C 1-10 alkyl and halo-substituted C 1-10 alkoxy; Z is C 1-6 alkylene; wherein up to two methylene groups of Z can be replaced with divalent radicals chosen from —NR 7 —, C 3-8 cycloalkylene, C 3-8 heterocycloalkylene and phenylene; wherein R 7 is chosen from hydrogen, C 1-6 alkyl and (CH 2 ) 1-2 COOH; wherein Z may further be substituted by 1 to 3 radicals chosen from halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; or when a —NR 7 — replaces at least one methylene group of Z, R 7 and Y together with the nitrogen atom to which R 7 is attached, forms C 8-14 heteroarylene; or a pharmaceutically acceptable salt thereof.