Patent ID: 7390789

Claim:
A compound of formula III: wherein C 1 is of configuration S or R; wherein R 1 is hydrogen, methyl, or wherein A is a hydrogen, straight or branched chain lower alkyl having 1 to 8 carbon atoms, straight or branched chain lower alkenyl or alkynyl having 2 to 8 carbon atoms, cyclic alkyl or ailcenyl having 4 to 8 carbon atoms, phenyl, or benzyl; wherein X is (L)-prolyl, 3,4-dehydro-(L)-prolyl, (2S, 3R)-3-methylpyrrolidine-2-carbonyl, (2S, 5R)-5-methylpyrrolidine-2-carbonyl, (S)-piperidine-2-carbonyl, or (R)-thiazolidine-4-carbonyl; X is connected to the carbonyl carbon of Formula III by a peptide bond; wherein Y is a dipeptide, where in the dipeptide the first (N-terminal) amino acid is (L)-prolyl, 3,4-dehydro-(L)-prolyl, (2S, 3R)-3-methylpyrrolidine-2-carbonyl, (2S, 3S)-3-methylpyrrolidine-2-carbonyl, (2S, 4R)-4-methylpyrrolicline-2-carbonyl, (2S, 4S)-4-methylpyrrolidine-2-carbonyl, (2S, 5R)-5-metbylpyrrolidine-2-carbonyl, (2S, 4R)-4-hydroxypyrrolidine-2-carbonyl, (2S, 4S)-4-hydroxypyrrolidine-2-carbonyl, (S)-piperidine-2-carbonyl, or (R) -thiazolidine-4-carbonyl, and the second (C-terminal) amino acid is (L)-alanyl, (L)-prolyl, sarcosyl, an (S, or R) N-methyl amino acid with a hydrophobic side chain, β-alanine, or other β-amino acid with a hydrophobic side chain, or a D-amino acid with a hydrophobic side chain; the dipeptide Y is connected to X by a peptide bond; and wherein Y further has a carboxyl, carboxyamide, or a —COOR 2 moiety at its carboxyl terminus; wherein R 2 is alkyl or substituted alkyl, having 1-6 carbon atoms; or cycloalkyl-(CH 2 ) a —, aryl-(CH 2 ) a —, substituted aryl-(CH 2 ) a —, or heteroaryl-(CH 2 ) a —, having 4-12 carbon atoms; and a is zero or an integer from 1 to 6.