Patent ID: 6887848

Claim:
A method of inducing angiogenesis comprising: administering an effective amount of a vascular endothelial growth factor VEGF (hVEGF 121 ) variant to a patient in need thereof, wherein the VEGF variant comprises amino acids 27-147 of SEQ ID NO:2, and wherein SEQ ID NO:2 has been altered by an amino acid substitution or deletion at (position 142 of SEQ ID NO:2); and wherein SEQ ID NO:2 has been altered by an amino acid substitution or deletion at position 101, 102, or 103, such that the variant is not glycosylated, said variant having at least 85% sequence identity with hVEGF121 polypeptide (amino acids 27-147 of SEQ ID NO:2), whereby angiogenesis is induced by the VEGF variant administered.