Patent ID: 8355874

Claim:
A method for developing a biomarker for prognosis of the result of a therapeutic treatment with the aid of data from clinical studies, the data unmodified by the therapeutic treatment being divided into clinical and genomic parameters and the marker being defined by a combination of parameters, said method comprising the following steps: a. Inputting to a computer: i. a subject group COH 0 , its z parameters and x parameters, ii. a quality requirement Q 0 for the clinical applicability requirements, iii. an allowed total complexity c, b. Searching for a set of from 1 to c clinical parameters which characterizes a subgroup of subjects SG 1 , a quality q of whose clinical reaction has quality requirements q>Q 0 , c. Defining a subject group COH 1 as COH 0 minus SG 1 , d. Searching for one or more sets of (c-1) z parameters and one x parameter which characterize a subgroup of subjects SG 2 , a quality q of whose clinical reaction has the quality requirements q>Q 0 , e. Defining a subject group COH 2 as COH 1 minus SG 2 , f. Searching for one or more sets of (c-n) z parameters and n x parameters, where n=0 to c, which characterize a subgroup of subjects SG n+1 , a quality q of whose clinical reaction has the quality requirements q>Q 0 , g. Defining a subject group COH n+1 as COH n minus SG n+1 , h. Repeating steps f) to g) until no subgroups are found or n=c, i. Forming a remainder group COH R , and j. Outputting from the computer a list of identified markers and a list of subjects of the remainder group COH R .