Patent ID: 7074311

Claim:
A method of performing gel electrophoresis comprising: (a) separating molecules in a gel by electrophoresis, wherein the gel comprises a top surface and a bottom surface, wherein a calorimetric resonant label-free biosensor is in the gel, wherein the biosensor comprises: (i) a one- or two-dimensional grating comprised of a high refractive index material deposited on a substrate comprising a low refractive index material; (ii) a film of electrically conducting material on a top surface of the grating; and (iii) one or more receptor molecules immobilized on the electrically conducting material; (b) applying a metal sheet to the top surface of the gel, so that the separated molecules are between the metal sheet and the immobilized receptor molecules of the biosensor; and (c) applying voltage between the metal plate and the biosensor so that the separated molecules move towards the immobilized receptor molecules of the biosensor.