Patent ID: 7022728

Claim:
A method of treating male erectile dysfunction in a male mammal comprising administering to said mammal in need of such treatment a therapeutically effective amount of a compound of formula (I) a pharmaceutically acceptable salt, ester, or amide thereof, wherein A is a selected from the group consisting of X is selected from the group consisting of NH, O and S; L is selected from the group consisting of CH 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 and CH 2 CH 2 CH 2 CH 2 ; R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from the group consisting of hydrogen, alkoxy, alkenyl, alkyl, alkylsulfinyl, alkylsulfonyl, alkylthio, alkynyl, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, carboxy, cyano, formyl, halogen, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, mercapto, nitro, —NZ 1 Z 2 , (NZ 1 Z 2 )carbonyl and (NZ 1 Z 2 )sulfonyl wherein Z 1 and Z 2 are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl and formyl; R A , R B , R C and R D are each independently selected from the group consisting of hydrogen, alkoxy, alkenyl, alkyl, alkylsulfinyl, alkylsulfonyl, alkylthio, alkynyl, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, carboxy, cyano, formyl, halogen, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, mercapto, nitro, —NZ 1 Z 2 and (NZ 1 Z 2 )carbonyl; R E is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, heterocyclecarbonyl and (NZ 1 Z 2 )carbonyl; R F is selected from the group consisting of hydrogen and alkyl; Z is selected from the group consisting of N, C and CH; and --- is a bond when Z is C and --- is absent when Z is N or CH.