Patent ID: 8507503

Claim:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof, wherein, R 1 and R 2 , which may be the same or different, are independenly selected from hydrogen, substituted or unsubstituted alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, arylalkyl, (CR x R y )OR x , COR x , COOR x , CONR x R y , and (CH 2 ) n CHR x R y ; R 3 is selected from hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl; L is a linker selected from —(CR x R y ) n —, —O—(CR x R y )-, —C(O)—, —NR x —,—S(O) m NR x —, —NR x (CR x R y )— and —S(O) m , NR x (CR x R y ) n ; Z 1 and Z 2 are independently sulfur or CR a ; with a proviso that either of Z 1 or Z 2 is always sulfur; R a is selected from hydrogen, cyano, halogen, substituted or unsubstituted alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, OR x , (CR x R y ) n OR x , COR x , COOR x , CONR x R y , S(O) m NR x R y , NR x R y , NR x (CR x R y ) m OR x , (CH 2 )NR x R y , (CH 2 ) n CHR x R y , NR x (CR x R y ) n CONR x R y , (CH 2 ) n NHCOR x , (CH 2 ) n NH(CH 2 ) n SO 2 R x , (CH 2 ) n NHSO 2 R x , SR x and OR x ; U is selected from substituted or unsubstituted aryl, substituted or unsubstituted five membered heterocycles selected from the group consisting of thiazole, isothiazole, oxazole, isoxazole, thiadiazole, oxadiazole, pyrazole, imidazole, furan, thiophene, pyrrole, 1,2,3-triazole, and 1, 2, 4-triazole, or substituted or unsubstituted six membered heterocycle selected from the group consisting of pyrimidine, pyridine and pyridazine; V is selected from hydrogen, cyano, nitro, —NR x R y , halogen, hydroxyl, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, haloalkyl, haloalkoxy, cycloalkylalkoxy, aryl, arylalkyl, biaryl, heteroaryl, heteroarylalkyl, heterocyclic ring and heterocyclylalkyl, —C(O)OR x , —OR x , —C(O)NR x R y , —C(O)R x , and —SO 2 NR x R y ; or U and V together may form an optionally substituted 3 to 7 membered saturated or unsaturated cyclic ring that may optionally include one or more heteroatoms selected from O, S and N; at each occurrence, R x and R y are independently selected from hydrogen, hydroxyl, halogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic ring and heterocyclylalkyl; and at each occurrence, ‘m’ and ‘n’ are independently selected from 0 to 2, both inclusive.