Patent ID: 7816359

Claim:
A pharmaceutical composition comprising, a) one or more pharmaceutically acceptable excipients, and b) at least one pharmaceutically active compound of formula IV R 3 ′ is (4-methyl-piperazinyl)-methyl and R 1 ′, R 2 ′, R 4 ′ and R 5 ′ are independently hydrogen, cyano; lower alkyl; hydroxy- or amino-substituted lower alkyl; trifluoromethyl; free, etherified or esterified hydroxy; lower alkoxy; lower alkanoyloxy; free, alkylated or acylated amino; mono- or di-lower alkylamino; lower alkanoylamino; benzoylamino; free or esterified carboxy; lower alkoxycarbonyl and halogen; R 6 is halogen, NH 2 , NO 2 , NHC(O)CF 3 , NHC(O)CH 3 , or NHC(NH)NH 2 , R 7 is methyl and R 8 is hydrogen; and one of the radicals R 6 ′, R 7 ′ and R 8 ′ is wherein R 10 is 4-pyrazinyl, 1-methyl-1H-pyrrolyl, amino- or amino-lower alkyl-substituted phenyl wherein the amino group in each case is free, alkylated or acylated, 1H-indolyl or 1H-imidazolyl bonded at a five-membered ring carbon atom, or unsubstituted or lower alkyl-substituted pyridyl bonded at a ring carbon atom and unsubstituted or substituted at the nitrogen atom by oxygen, and R 11 and R 12 are each independently of the other hydrogen or lower alkyl and the other two radicals are hydrogen, lower alkyl, benzyl or phenyl, or a pharmaceutically acceptable salt or crystal form thereof; and c) between 0.00001% and 5% by weight of at least one compound of formula I wherein R 3 is (4-methyl-piperazinyl)-methyl and R 1 , R 2 , R 4 and R 5 are independently hydrogen, cyano; lower alkyl; hydroxy- or amino-substituted lower alkyl; trifluoromethyl; free, etherified or esterified hydroxy; lower alkoxy; lower alkanoytoxy; free, alkylated or acylated amino; mono- or di-lower alkylamino; lower alkanoylamino; benzoylamino; free or esterified carboxy; lower alkoxycarbonyl and halogen; R 6 is halogen, NH 2 , NO 2 , NHC(O)CF 3 , NHC(O)CH 3 , or NHC(NH)NH 2 , R 7 is methyl and R 8 is hydrogen; or a salt or crystal form thereof.