Patent ID: 8722718

Claim:
A compound of Formula I or a tautomer or pharmaceutically acceptable salt thereof, wherein: W is wherein each R 4 is independently H, F, Cl, Br, I, OH, OCH 3 , OCH 2 CH 3 , SC (1-4) alkyl, SO 2 C (1-4) alkyl, —C (1-3) alkyl, CO 2 R d , CONR e R f , C≡CR g , or CN; wherein R d is H, or —C (1-3) alkyl; R e is H, or —C (1-3) alkyl; R f is H, or —C (1-3) alkyl; and R g is H, —CH 2 OH, or —CH 2 CH 2 OH; R 2 is cycloalkyl, spiro-substituted cycloalkenyl, or phenyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy, C (1-3) alkyl, and C (1-4) alkyl; Z is H, F, or CH 3 ; J is CH; X is R 5 is H, —C (1-6) alkyl, —OC (1-4) alkyl, —CN, —NA 3 A 4 , —SO 2 CH 3 , —CO 2 C (1-4) alkyl, —CH 2 —NA 3 A 4 , —CH 2 CH 2 NA 3 A 4 , —CONA 3 A 4 , —CH 2 OC (1-4) alkyl, —OC (1-4) alkylOR a , —NHCH 2 CH 2 CO 2 C (1-4) alkyl, —NHCH 2 CH 2 OC (1-4) alkyl, —N(C (1-4) alkyl)CH 2 CH 2 NA 3 A 4 , —OC (1-4) alkylNA 3 A 4 , —OCH 2 CO 2 C (1-4) alkyl, —CH 2 CO 2 C (1-4) alkyl, —CH 2 CH 2 SO 2 C (1-4) alkyl, —SO 2 CH 2 CH 2 NA 3 A 4 , —SOCH 2 CH 2 NA 3 A 4 , —SCH 2 CH 2 NA 3 A 4 , —NHSO 2 CH 2 CH 2 NA 3 A 4 , and phenyl; A 3 is —C (1-4) alkyl, or CH 2 CH 2 OR a ; A 4 is —C (1-4) alkyl, COR a , CH 2 CON(CH 3 ) 2 , —CH 2 CH 2 OR a , —CH 2 CH 2 SC (1-4) alkyl, —CH 2 CH 2 SOC (1-4) alkyl, or —CH 2 CH 2 SO 2 C (1-4) alkyl.