Patent ID: 7250427

Claim:
A compound having Cds1 modulating activity of formula (I): wherein W is —COOH, —(CO)NH 2 , or —(SO 2 )NH 2 ; Q is N or CH; R a and R b are each independently selected from —H and halogen; R c is absent or is independently selected from the group consisting of —OH, —CF 3 , —C 1-4 alkyl, —OC 1-4 alkyl, —NO 2 , and halo; n is selected from the group consisting of 0, 1, and 2; m is selected from the group consisting of 0, 1, and 2; R d is —H or —C 1-4 alkyl, optionally mono- or di-substituted with a substituent selected from the group consisting of —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl) 2 , —OH, and —OC 1-4 alkyl; A is selected from the group consisting of —CR e OH and —R y R z , where if A is —NR y R z , m+n must be greater than zero; R e is —H or —C 1-4 alkyl, optionally mono- or di-substituted —C 1-4 alkyl with a substituent selected from the group consisting of —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl) 2 , —OH, —OC 1-4 alkyl, —CF 3 , and fluoro; alternatively, R d and R e may be taken together with their carbons of attachment to form an aliphatic hydrocarbon ring, said ring having four to seven members, optionally having one or two unsaturated bonds in the ring, and optionally substituted with a substituent selected from the group consisting of —C 1-4 alkyl, —OC 1-4 alkyl, and fluoro; R y is independently selected from the group consisting of —H, —C 1-4 alkyl optionally substituted with —OC 1-4 alkyl, and benzyl optionally mono- or di-substituted with —OC 1-4 alkyl, —C 1-4 alkyl, or halo; alternatively, R d and R y may be taken together with their atoms of attachment to form a five to eight-membered heterocyclic ring, with the heterocyclic ring having zero or one unsaturated bonds, having zero, one, or two carbon members which is a carbonyl, having zero or one additional heteroatom members selected from the group consisting of O, S, —N═, >NH, and >NC 1-4 alkyl and separated from the nitrogen of R y attachment by at least one carbon member, and optionally having a substituent selected from the group consisting of —C 1-4 alkyl, —OC 1-4 alkyl, and fluoro; R z is —H or is selected from the group consisting of —C 1-6 alkyl, —C 3-6 cycloalkyl, —C 1-4 alkylC 3-6 cycloalkyl, phenyl, benzyl, pyridylmethyl, —C(O)C 1-6 alkyl, —C(O)phenyl, —C(O)pyridyl, —C(O)OC 1-6 alkyl, and —C(O)Obenzyl, each optionally mono-, di-, or tri-substituted with a substituent selected from the group consisting of —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl) 2 , —OH, —OC 1-4 alkyl, —C 1-4 alkyl, and halo; and alternatively, R y and R z may be taken together with the nitrogen of attachment to form an otherwise aliphatic hydrocarbon ring, said ring having five to seven members, optionally having one carbon replaced with >O, >S(═O) 0-2 , ═N—, >NH, and >N(C 1-4 alkyl), optionally having one or two unsaturated bonds in the ring, and optionally having a substituent selected from the group consisting of —C 1-4 alkyl, —OC 1-4 alkyl, and fluoro; and enantiomers, diastereomers, and pharmaceutically acceptable salts, esters or amides thereof.