Patent ID: 7723382

Claim:
A process for preparing a compound of general formula (A) wherein R 1 -R 12 are the same or different and independently are hydrogen, straight or branched C 1 -C 6 alkyl, optionally substituted with aryl; m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO 2 , NR 13 or PR 13 , in which R 13 is hydrogen, C 1 -C 6 alkyl, or X is selected from the group consisting of: saturated or unsaturated C 5 -C 7 cycloalkylene, optionally substituted with one or more straight or branched C 1 -C 3 alkyl groups; arylene, optionally substituted with one or more halogen atoms, straight or branched alkyl groups containing from 1 to 4 carbon atoms, or a straight or branched C 1 -C 3 perfluoroalkyl; a 5 or 6 member saturated, unsaturated, or aromatic heterocyclic ring selected from and R is the radical of a pharmacologically active compound selected from the group consisting of: wherein M is a carbon or nitrogen atom; R c is selected from: H, OH, NH 2 , R E CONH—, R E COO—, an heterocyclic residue with 5 or 6 atoms that may be aromatic, saturated or unsaturated, containing one or more heteroatoms selected from oxygen, nitrogen or sulfur, and phenylamino (PhNH—), in which the aromatic ring may be substituted with one or more substituents selected from the group consisting of halogen, straight or branched C 1 -C 4 -alkyl and straight or branched perfluoroalkyl; e is 0 or 1; R E is selected from the group consisting of straight or branched C 1 -C 5 -alkyl, phenyl substituted with OCOR F , wherein R F is selected from the group consisting of methyl, ethyl or straight or branched C 3 -C 6 -alkyl or phenyl; R D is selected from: H, OH, halogen, —NH 2 , straight or branched C 1 -C 6 -alkoxy, perfluoroalkyl having from 1 to 4 carbon atoms and mono or di-(C 1 -C 6 )alkylamino; with the proviso that R C and R D cannot both be H: wherein R F1 and R F2 are halogens selected from chlorine, fluorine or bromine, R G is hydrogen, straight or branched C 1 -C 6 -alkyl; wherein the bond at 6 position in formula (XXVIII) may be α or β; and wherein in all the formulae (I-XXXI) listed above, the wavy line represents the position wherein —COO— group is bound; said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as above defined and Z is hydrogen or a cation selected from Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C) wherein R 1 -R 12 and m, n, o, p, q, r, s are as defined above and Y is R A SO 3 —, in which R A is a straight or branched C 1 -C 6 alkyl, optionally substituted with one or more halogen atoms, or a C 1 -C 6 alkylaryl.