Patent ID: 8758658

Claim:
A process for the manufacture of a uniaxially compressed pharmaceutical composition, the process comprising: 1) preparing a three-dimensionally printed pharmaceutical composition having a predetermined spatially nonuniform internal composition before uniaxial compression that is substantially the same as the spatially nonuniform internal composition after uniaxial compression comprising powder particles bound together by a binding substance; and 2) uniaxially compressing comprising a) placing the three-dimensionally printed pharmaceutical composition in a die assembly having confining surface which substantially surround the dosage form from all directions except for one direction and, in that direction, the die assembly having an opening which defines an axis of compression and b) moving a ram along the axis of compression into the opening, thereby uniaxially compressing the dosage form having a surface finish having a peak-to-valley dimension wherein the peak-to-valley dimension is less than or approximately equal to 3 microns to form the uniaxially compressed pharmaceutical composition having a void fraction of less than 5%.