Patent ID: 8293906

Claim:
A process for the preparation of a compound of Formula (II), the process comprising: (a) forming a reaction mixture by combining a compound of Formula (I) with MCO 3 , a catalytic additive, and R 1 X 1 , the amount of alkenyl impurity comprising R 1 X 1 being less than 0.15% by weight; and (b) heating the reaction mixture to a temperature of less than 60° C. to form the compound of Formula (II) according to the following reaction scheme: wherein; R 1 is selected from the group consisting of an alkyl, a substituted alkyl, and a cycloalkyl; R 2 and R 3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {—}OH, {—}NH 2 , {—}SH, {—}SR 11 , and {—}OR 11 ; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; R 8 is selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 9 , R 10 , and R 11 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; M is selected from the group consisting of a metal cation having a charge of + 1, and a metal cation group having a charge of + 2; X is oxygen; and X 1 is a halogen.