Patent ID: 7718845

Claim:
A method of producing a recombinant growth hormone comprising: a. making a non-human transgenic mammal of bovine species that produces a growth hormone in its milk, wherein said mammal produces increased growth hormone in its serum over a nontransgenic mammal of bovine species, and wherein said mammal is made by a process of nuclear transfer comprising: i) enucleating a mature bovine oocyte, resulting in an enucleated oocyte; ii) fusing said enucleated oocyte with a bovine somatic cell, resulting in a monocell embryo, wherein said bovine somatic cell comprises an integrated plasmid which comprises a growth hormone gene operably linked to a promoter that directs expression of said gene in mammary cells of said mammal of bovine species; b. obtaining said milk from said non-human transgenic mammal; and c. purifying said growth hormone from said milk.