Patent ID: 7678819

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: A 1 is CH A 2 is CH or N; R 1 and R 2 are each independently: hydrogen, —NHC 1-4 alkyl, —N(C 1-4 alkyl) 2 , —NH 2 , C 1-4 alkoxy or —OH; R 3 fragment i, ii or iii, wherein: fragment i is: wherein n is an integer from 1 to 10; m is an integer from 0 to 5; y is an integer from 0 to 5; R 5 is hydrogen, C 1-4 alkyl, or hydroxy(C 1-4 )alkyl; R a , R b , R c , R d , R e , R f , R g and R h are each independently hydrogen, halogen, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, or hydroxy(C 1-4 )alkyl; and Z is: a) X, wherein X is hydrogen, hydroxy, halogen, radiohalogen, C 1-4 alkoxy, hydroxy(C 1-4 )alkyl, halo(C 1-4 )alkyl, radiohalo(C 1-4 )alkyl or NR x R y , wherein R x and R y are independently hydrogen, C 1-4 alkyl, hydroxy(C 1-4 )alkyl, radiohalo(C 1-4 )alkyl or halo(C 1-4 )alkyl; b) one of the following groups, each of which contains X as a substituent: benzoyloxy, phenyl(C 1-4 )alkyl, aryloxy or C 6-10 aryl; or c) Zc, having the following structure: wherein p is an integer from 1 to 4, Q is O or NR 5 and G is —C═C—(R G )X or —C≡C—X, wherein R G is hydrogen or C 1-4 alkyl, and R n and R o are independently hydrogen, hydroxyl or C 1-4 alkyl; fragment ii is: wherein y′is an integer from 0 to 5; and fragment iii is: wherein e is 0 or 1; R 4 is hydrogen, halogen, or radiohalogen; provided that, if X is not or does not contain F or 18 F, then R 4 is F, 18 F 123 I, 125 I, 131 I, 76 Br, or 77 Br or Br.