Patent ID: 8192972

Claim:
A crystal comprising: a human Janus Kinase 3 kinase domain consisting of amino acid residues 810-1115 of SEQ ID NO: 1, wherein said human Janus Kinase 3 kinase domain is in complex with a chemical entity selected from the group consisting of adenosine, ATP, an ATP analogue, AMP-PNP, a nucleotide triphosphate, a nucleotide diphosphate, and phosphate, and wherein said crystal is characterized by either: (i) space group P2 1 and has unit cell parameters of a=59.98±4 Å, b=90.19 ±4 Å, c=69.00±4 Å, α=90°, β=111.5°±8°, and γ=90°, or (ii) space group P2 1 2 1 2 1 and has unit cell parameters of a=72.36±4 Å, b=90.04±4 Å, c=105.60±4 Å, α=90°, β=90°, and γ=90°.