Patent ID: 8512728

Claim:
A method of forming a medical device on biological tissue comprising: attaching a plurality of reactive members of a primary specific binding pair to a surface of the biological tissue; providing a plurality of fibers having attached thereto a plurality of complementary reactive members of the primary specific binding pair, and a plurality of reactive members and complementary reactive members of an orthogonal specific binding pair, wherein upon contact of the reactive members of the primary specific binding pair on the surface of the biological tissue with the complimentary reactive members of the primary specific binding pair on the fibers, covalent bonds are formed via click chemistry between the reactive members and the complementary reactive members of the primary specific binding pair, adhering the fibers to the biological tissue, and, wherein upon contact of the reactive members of the orthogonal specific binding pair on the fibers with the complimentary reactive members of the orthogonal specific binding pair on the fibers, covalent bonds are formed via click chemistry between the reactive members and the complementary reactive members of the orthogonal specific binding pair, adhering the fibers to each other.