Patent ID: 7662837

Claim:
The novel compounds of Formula I: or a tautomer or pharmaceutically acceptable salt thereof, wherein: A is phenyl or pyridyl, either of which may be substituted with one of chloro, fluoro, methyl, —N 3 , —NH 2 , —NH(alkyl), —N(alkyl) 2 , —S(alkyl), —O(alkyl), or 4-aminophenyl; W is pyrrolyl, imidazolyl, isoxazolyl, oxazolyl, 1,2,4 triazolyl, or furanyl, any of which may be connected through any carbon atom, wherein the pyrrolyl, imidazolyl, isoxazolyl, oxazolyl, 1,2,4 triazolyl, or furanyl may contain one —Cl, —CN, —NO 2 , —OMe, or —CF 3 substitution, connected to any other carbon; R 2 is cycloalkyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl, or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, and C (1-3) alkyl, with the proviso that tetrahydropyridyl is connected to the ring A through a carbon-carbon bond; X is Z is CH or N; D 1 and D 2 are each hydrogen or taken together form a double bond to an oxygen; D 3 and D 4 are each hydrogen or taken together form a double bond to an oxygen; D 5 is hydrogen or —CH 3 , wherein said —CH 3 may be relatively oriented syn or anti; R a and R b are independently hydrogen, cycloalkyl, haloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; E is N, S, O, SO or SO 2 , with the proviso that E may not be N if the following three conditions are simultaneously met: Q a is absent, Q b is absent, and R 3 is an amino group or cyclic amino radical wherein the point of attachment to E is N; Q a is absent, —CH 2 —, —CH 2 CH 2 —, or C(O); Q b is absent, —NH—, —CH 2 —, —CH 2 CH 2 —, or C(O), with the proviso that Q b may not be C(O) if Q a is C(O), and further provided that Q b may not be —NH— if E is N and Q a is absent, further provided that Q b may not be —NH— if R 3 is an amino group or cyclic amino radical wherein the point of attachment to Q b is N; R 3 is hydrogen, hydroxyalkylamino, (hydroxyalkyl) 2 amino, alkylamino, aminoalkyl, dihydroxyalkyl, alkoxy, dialkylamino, hydroxyalkyl, —COOH, —CONH 2 , —CN, —SO 2 -alkyl-R 4 , —NH 2 , or a 5 or six membered ring which contains at least one heteroatom N and may optionally contain an additional heteromoiety selected from S, SO 2 , N, and O, and the 5 or 6 membered ring may be saturated, partially unsaturated or aromatic, wherein aromatic nitrogen in the 5 or 6 membered ring may be present as N-oxide, and the 5 or 6 membered ring may be optionally substituted with methyl, halogen, alkylamino, or alkoxy; R 3 may also be absent, with the proviso that R 3 is not absent when E is nitrogen; R 4 is hydrogen, —OH, alkoxy, carboxy, carboxamido, or carbamoyl.