Patent ID: 7169798

Claim:
A compound having the formula wherein: X—Y-Z is selected from one of the following: R 1 is H, CONH 2 , T( n )-R, or T( n )-Ar 2 ; R is an aliphatic or substituted aliphatic group; n is zero or one; T is C(═O), CO 2 , CONH, S(O) 2 , S(O) 2 NH, COCH 2 or CH 2 ; each R 2 is independently selected from hydrogen, —R, —CH 2 OR, —CH 2 OH, —CH═O, —CH 2 SR, —CH 2 S(O) 2 R, —CH 2 (C═O)R, —CH 2 CO 2 R, —CH 2 CO 2 H, —CH 2 CN, —CH 2 NHR, —CH 2 N(R) 2 , —CH═N—OR, —CH═NNHR, —CH═NN(R) 2 , —CH═NNHCOR, —CH═NNHCO 2 R, —CH═NNHSO 2 R, -aryl, -substituted aryl, —CH 2 (aryl), —CH 2 (substituted aryl), —CH 2 NH 2 , —CH 2 NHCOR, —CH 2 NHCONHR, —CH 2 NHCON(R) 2 , —CH 2 NRCOR, —CH 2 NHCO 2 R, —CH 2 CONHR, —CH 2 CON(R) 2 , —CH 2 SO 2 NH 2 , —CH 2 (heterocyclyl), —CH 2 (substituted heterocyclyl), -(heterocyclyl), or -(substituted heterocyclyl); each R 3 is independently selected from hydrogen, R, COR, CO 2 R or S(O) 2 R; G is R or Ar 1 ; Ar 1 is aryl, substituted aryl, aralkyl, substituted aralkyl, heterocyclyl, or substituted heterocyclyl, wherein Ar 1 is optionally fused to a partially unsaturated or fully unsaturated five to seven membered ring containing zero to three heteroatoms; Q-NH is wherein the H of Q-NH is optionally replaced by R 3 ; A is CR 3 ; Ar 2 is aryl, substituted aryl, heterocyclyl or substituted heterocyclyl, wherein Ar 2 is optionally fused to a partially unsaturated or fully unsaturated five to seven membered ring containing zero to three heteroatoms; wherein each substitutable carbon atom in Ar 2 , including the fused ring when present, is optionally and independently substituted by halo, R, OR, SR, OH, NO 2 , CN, NH 2 , NHR, N(R) 2 , NHCOR, NHCONHR, NHCON(R) 2 , NRCOR, NHCO 2 R, CO 2 R, CO 2 H, COR, CONHR, CON(R) 2 , S(O) 2 R, SONH 2 , S(O)R, SO 2 NHR, or NHS(O) 2 R, and wherein each saturated carbon in the fused ring is further optionally and independently substituted by ═O, ═S, ═NNHR, ═NNR 2 , ═N—OR, ═NNHCOR, ═NNHCO 2 R, ═NNHSO 2 R, or ═NR; and wherein each substitutable nitrogen atom in Ar 2 is optionally substituted by R, COR, S(O) 2 R, or CO 2 R.