Patent ID: 7374900

Claim:
A compound of the formula I: wherein R 3 is selected from the group consisting of H, cyano, C 1 -C 6 alkyl, C 1 -C 6 perfluoroalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, and heteroaryl, formyl, carboxamide of the formula —(C═O)NR 1 R 2 where R 1 and R 2 are independently H, alkyl having 1-6 carbon atoms, an aryl, or R 1 and R 2 taken together form a saturated 5- or 6- membered ring having the formula —(CH 2 ) 2 —M—(CH 2 ) 2 — where the ring moiety M is a single bond, an oxygen atom, a methylene group, or the secondary amine —NR 7 — where R 7 is H or alkyl having 1-6 carbon atoms; R 4 is selected from the group consisting of H, hydroxyl, cyano, nitro, halo, amino, amido, azido, acetal, ketal, imido, sulfo, sulfonyl, sulfinyl, sulfomethyl, salt of sulfomethyl, thiocyanato, aldehydo, keto, carbamoyl, urethane, ureido, guanidino, C 1 -C 6 alkylamino, C 1 -C 6 acylamino, C 1 -C 6 alkylamido, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 perfluoroalkyl, halomethyl, C 1 -C 6 alkylthio, C 5 -C 8 cycloalkyl, C 1 -C 6 haloalkyl, C 5 -C 8 halocycloalkyl, C 1 -C 6 hydroxyalkyl, C 5 -C 8 hydroxycycloalkyl, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 2 -C 6 alkoxycarbonyl, C 2 -C 6 alkoxycarbonyl C 1 -C 6 alkyl, carboxy C 1 -C 6 alkyl, carboxy C 1 -C 6 alkoxy, dicarboxy C 1 -C 6 alkyl, dicarboxy C 1 -C 6 alkoxy, C 2 -C 6 cyanoalkyl, phosphono C 1 -C 6 alkyl, phosphoryl C 1 -C 6 alkyl, mono-, di-, and trisaccharides, nucleic acids, oligonucleotides, amino acids, peptides, and proteins, and C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, arylcarbonyl, and heteroaryl, which may be optionally substituted with a substituent selected from the group consisting of hydroxyl, cyano, nitro, halo, amino, amido, azido, acetal, ketal, imido, sulfo, sulfonyl, sulfinyl, thiocyanato, aldehydo, keto, carbamoyl, urethane, ureido, and guanidine; R 5 is H or C 1 -C 6 alkoxy; R 9 and R 10 are ethyl; R 6 and R 8 are halo; and X 1 , X 2 , and X 3 are independently O or S.