Patent ID: 8871247

Claim:
A poly-β-1→4-N-acetylglucosamine composition comprising biocompatible poly-β-1→4-N-acetylglucosamine fibers, wherein (i) the majority of the fibers are less than about 15 μm in length, wherein the fibers have been irradiated to reduce the length of the fibers, and (ii) the composition (a) increases metabolic rate of serum-starved human umbilical cord vein endothelial cells in a MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and/or does not rescue apoptosis of serum-starved human umbilical cord vein endothelial cells in a trypan blue exclusion test, and (b) is non-reactive when tested in an intramuscular implantation test.