Patent ID: 7087768

Claim:
A fumagillol compound represented by the following formula I, or a pharmaceutically acceptable salt thereof: wherein, X is —OH and Y is halogen, or X and Y are linked together to form an oxyrane ring, B represents —(C═O)— or —CH 2 —, R 1 represents hydroxy; —CN; —NO 2 ; —CF 3 ; formyl; C 1 –C 4 thioalkyl; acetamido; acetoxy; C 1 –C 6 alkoxy; C 1 –C 6 aminoalkoxy; C 1 –C 4 alkylaminoalkoxy; C 1 –C 4 dialkylaminoalkoxy; amino; C 1 –C 6 alkylamino; C 1 –C 4 dialkylamino; C 1 –C 4 alkyloxycarboxylic acid; C 3 –C 6 cycloalkyl or in which R 2 , R 3 , R 4 , R 5 and R 6 , which are the same or different, each represents hydrogen; hydroxy; —CN; —NO 2 ; —CF 3 ; formyl; C 1 –C 4 thioalkyl; acetamido; acetoxy; C 1 –C 6 alkyl; C 1 –C 4 aminoalkyl; C 1 –C 4 alkylaminoalkyl; C 1 –C 4 dialkylaminoalkyl; C 1 –C 6 alkoxy; C 1 –C 6 aminoalkoxy; C 1 –C 4 alkylaminoalkoxy; C 1 –C 4 dialkylaminoalkoxy; amino; C 1 –C 6 alkylamino; C 1 –C 4 dialkylamino; C 1 –C 4 hydroxyalkyl; or C 1 –C 4 alkyloxycarboxylic acid; or, R 2 and R 3 , R 3 and R 4 , R 4 and R 5 , or R 5 and R 6 , are linked together to form a C 1 –C 3 alkylene dioxy ring, and Z 1 , Z 2 , Z 3 , Z 4 and Z5 each represent carbon or nitrogen.