Patent ID: 7625904

Claim:
A method for the treatment of a sleep disorder selected from dysomnia, insomnia, and circadian rhythmic disorder, in a mammal in need thereof, said method comprising administering an effective amount of a compound of formula (I): wherein R is a halogen atom or a C 1-4 alkyl group; R 1 is hydrogen or a C 1-4 alkyl group; R 2 is hydrogen, a C 1-4 alkyl, C 2-6 alkenyl or a C 3-7 cycloalkyl group; or R 1 and R 2 together with nitrogen and carbon atom to which they are attached respectively are a 5-6 membered heterocyclic group; R 3 is a trifluoromethyl, a C 1-4 alkyl, a C 1-4 alkoxy, a trifluoromethoxy, or a halogen group; R 4 is hydrogen, a (CH 2 ) q R 7 or a (CH 2 ) r CO(CH 2 ) p R 7 group; R 5 is hydrogen, a C 1-4 alkyl or a COR 6 group; R 6 is hydrogen, hydroxy, amino, methylamino, dimethylamino, a 5 membered heteroaryl group containing 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen or a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms; R 7 is hydrogen, hydroxy or NR 8 R 9 wherein R 8 and R 9 are independently hydrogen or C 1-4 alkyl optionally substituted by hydroxy, or by amino; R 10 is hydrogen, a C 1-4 alkyl I group or R 10 together with R 2 is a C 3-7 cycloalkyl group; m is zero or an integer from 1 to 3; n is zero or an integer from 1 to 3; both p and r are independently zero or an integer from 1 to 4; q is an integer from 1 to 4; provided that, when R 1 and R 2 together with nitrogen and carbon atom to which they are attached respectively are a 5 to 6 membered heterocyclic group, i) m is 1 or 2; ii) when m is 1, R is not fluorine and iii) when m is 2, the two substituents R are not both fluorine, or a pharmaceutically acceptable salt thereof.