Patent ID: 7579350

Claim:
A compound having Formula I: wherein the pyridazine heterocycle is optionally atropisomeric with respect to X and/or W and wherein: X is a radical selected from the group consisting of: wherein A is either carbon or nitrogen, and Z is either hydrogen or (C 1-6 ) alkyl; W is a radical selected from the group consisting of: wherein B is either carbon or nitrogen; and R 1 is selected from the group consisting of side chains of amino acids other than glycine; a substituted or unsubstituted aralkyl or heterocyclylalkyl group; and a C 1-10 alkyl group, optionally comprising one or more unsaturated bonds within the alkyl chain, and optionally substituted with —OR 4 , —C(O)R 4 , —COOR 4 , —S(O) q R 4 , —NR 4 R 5 , —C(Y)NR 4 R 5 , —N(R 4 )C(Y)OR 5 , —NR 6 C(Y)NR 4 R 5 , —NR 6 C(NR 7 )NR 4 R 5 , —C(NR 6 )NR 4 R 5 , —C(Y)NR 4 OR 5, —S(O) 2 NR 4 R 5 , or —NR 4 —SO 2 —R 5 , wherein Y is O or S; R 2 and R 3 are independently selected from the group consisting of side chains of amino acids other than glycine; a substituted or unsubstituted aralkyl or heterocyclylalkyl group; a C 1-10 alkyl group, optionally comprising one or more unsaturated bonds within the alkyl chain, and optionally substituted with —OR 4 , —C(O)R 4 , —COOR 4 , —S(O) q R 4 , —NR 4 R 5 , —C(Y)NR 4 R 5, —N(R 4 )C(Y)OR 5 , —NR 6 C(Y)NR 4 R 5 , —NR 6 C(NR 7 )NR 4 R 5 , —C(NR 6 )NR 4 R 5, —C(Y)NR 4 OR 5 , —S(O) 2 NR 4 R 5 , or —NR 4 —SO 2 —R 5 , wherein Y is O or S; —C(O)—NH—R 8 ; and —NH—C(O)—R 9 ; R 4 , R 5 , R 6 , and R 7 , at each occurrence, are independently hydrogen or a substituted or unsubstituted C 1-8 alkyl, C 2-6 alkenyl, (C 0-6 alkylene)(C 6-10 aryl), or (C 0-6 alkylene)(C 3-9 heterocyclyl) group; or R 6 and R 7 , together with the N to which they are attached, form a substituted or unsubstituted heterocyclyl group; R 8 and R 9 , at each occurrence, are independently a side chain of an amino acid other than glycine; a substituted or unsubstituted aralkyl or heterocyclylalkyl group; a C 1-10 alkyl group, optionally comprising one or more unsaturated bonds within the alkyl chain, and optionally substituted with —OR 4 , —C(O)R 4 , —COOR 4 , —S(O) q R 4 , —NR 4 R 5 , —C(Y)NR 4 R 5 , —N(R 4 )C(Y)OR 5 , —NR 6 C(Y)NR 4 R 5 , —NR 6 C(NR 7 )NR 4 R 5 , —C(NR 6 )NR 4 R 5 , —C(Y)NR 4 OR 5 , —S(O) 2 NR 4 R 5 , or —NR 4 —SO 2 —R 5 , wherein Y is O or S; and each q is independently 0-2; and stereoisomers thereof, tautomers thereof, and pharmaceutically acceptable salts thereof.