Patent ID: 8097594

Claim:
Compounds having the structure of Formula I: and their pharmaceutically acceptable salts, pharmaceutically acceptable enantiomers or diastereomers, wherein * indicates a chiral center; R 1 is hydrogen or methyl; R 2 is hydrogen or hydroxyl protecting group, wherein hydroxyl protecting groups are selected from the group consisting of triethylsilyl, trimethylsilyl, acetyl, benzoyl, methoxymethyl, benzyl, methoxyethoxymethyl or tertbutyldimethylsilyl; Q is Het or wherein Het is selected from wherein R 3 is one or more substituent selected from the group consisting of NO 2 , CN, halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, CH 2 CONH 2 , CH 2 CO 2 Et, CH 2 CN, CH 2 CH 2 OH, CH 2 OCH 2 CH 2 OCH 3 , NH 2 , substituted C 1 -C 6 alkyl and substituted C 2 -C 6 alkenyl; T is selected from the group consisting of: hydrogen, —(CH 2 ) m —R 5 , —(CH 2 ) m —CH═CH—R 5 , —(CH 2 ) m —C═C—R 5 , (CH 2 ) m —R 5 , -A-(CH 2 ) m —CH═CH—R 5 , -A-(CH 2 ) m —C═C—R 5 , —(CH 2 ) m —B—R 5 , (CH 2 ) m —B—R 5 , —(CH 2 ) m —X—R 6 , —(CH 2 ) m —B-X—R 6 , —(CH 2 ) m —CH═CH—X—R 6 , —(CH 2 ) m —C≡C—X—R 6 , -A-(CH 2 ) m —X—R 6 , -A-(CH 2 ) m —B—X—R 6 , -A-(CH 2 ) m —CH═CH—X—R 6 and -A-(CH 2 ) m —C≡C—X—R 6 ; wherein, m is 0, 1, 2 or 3; R 5 is selected from the group consisting of: hydrogen, cyano, halogen, hydroxyl, CO 2 (C 1 -C 6 alkyl), CO NR a R b , NR a R b , C 1 -C 6 alkyl or substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl or substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl, 6 membered substituted or unsubstituted aryl, 5-6 membered substituted or unsubstituted heteroaryl, 3-6 membered substituted or unsubstituted cycloalkyl and 3-6 membered substituted or unsubstituted heterocyclyl; wherein R a and R b are independently hydrogen, C 1 -C 6 alkyl or R a and R b together with the nitrogen to which they are attached form a 5-6 membered heterocyclic ring wherein the heterocycle has one or more heteroatoms selected from N, O, S; A is —CO— or —CONH—; B is —O—, —S—, —SO—, —SO 2 —, —CO—, —CONH—, —CON(CH 3 )—, —NHCONH—, —C(NH 2 )═N—O—, wherein R 8 is a substitutent at any one of carbon of the heterocycle, R 8 is selected from the group comprising of hydrogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl and substituted C 2 -C 6 alkenyl; X is a 6 membered aryl or a 5-6 membered heteroaryl; R 6 is aryl, heteroaryl, substituted aryl or substituted heteroaryl; Y′ is hydrogen and Y is OR 7 , wherein R 7 is hydrogen or wherein R 2′ is hydrogen, (when R 2′ is hydrogen, R 7 is designated as cladinose) or hydroxyl protecting group, wherein hydroxyl protecting groups are selected from the group consisting of triethylsilyl, trimethylsilyl, acetyl, benzoyl, methoxymethyl, methoxyethoxymethyl, benzyl or tertbutyldimethylsilyl; or Y and Y′ together with the carbon to which they are attached form C═O.