Patent ID: 7833978

Claim:
A conjugate comprising a recombinant human thrombomodulin protein and a polymer, wherein the recombinant human thrombomodulin protein comprises epidermal growth factor (EGF)-like domains (4-6), a substitution of a leucine for a methionine at amino acid position 40 of SEQ ID NO:3 and a GGM amino acid motif appended at a carboxy terminus of said recombinant human thrombomodulin protein, wherein said recombinant human thrombomodulin protein comprises the amino acid sequence of SEQ ID NO:3 and wherein the polymer is selected from the group consisting of polyethylene glycol, poly(t-butyl acrylate), poly(t-butyl methacrylate), polyacrylamide, poly(arginine), glycolipid, glycoprotein and polysaccharide.