Patent ID: 8323616

Claim:
A process for the production of an 18 F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (Ib) SOLID SUPPORT-LINKER-I + -TRACER Y − (Ib) wherein Y − is an anion, the SOLID SUPPORT is a polymer selected from polystyrene which is optionally block grafted, polyacrylamide, and polypropylene or glass or silicon coated with such a polymer, the LINKER is selected from: wherein at each occurrence, k is an integer of 0 to 3, n is an integer of 1 to 16, and R L is hydrogen or C1-6alkyl; and wherein each phenyl ring is optionally substituted by 1 to 4 groups selected from C 1-6 alkyl and C 1-6 alkoxy; and the TRACER is of formula (Ab1) wherein: R 1 and R 2 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 haloalkyl, and a protecting group selected from alkoxycarbonyl; R 5 is hydrogen, C 1-6 alkyl, or a bond to the SOLID SUPPORT-LINKER-I + - group in formula (Ib); R 8 is hydroxy, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 alkyl, or a bond to the SOLID SUPPORT-LINKER-I + - group in formula (Ib); provided that only one of R 5 and R 8 is a bond to the SOLID SUPPORT-LINKER-I + - group in formula (Ib); with 18 F to produce the labelled tracer of formula (IIb) 18 F-TRACER (IIb) wherein the TRACER is as defined for the compound of formula (Ib) except that one of R 5 and R 8 is a bond to the 18 F instead of a bond to the SOLID SUPPORT-LINKER-I + - group in formula (Ib); optionally followed by: (i) removal of excess 18 F − ; and/or (ii) removal of any protecting groups; and/or (iii) removal of organic solvent; and/or (iv) formulation of the resultant compound of formula (IIb) as an aqueous solution.