Patent ID: 7588771

Claim:
A method of treatment of cancer, comprising administering a combination of a pharmaceutical composition, and an anti-cancer treatment or agent to a subject for treatment of cancer, wherein: the cancer comprises a solid tumor; treatment comprises an alleviation, reduction or amelioration of clinical symptoms or diagnostic markers associated with the tumor; the pharmaceutical composition comprises a recombinant vaccinia virus whose genome contains a modified thymidine kinase (TK) gene and a modified hemagglutinin (HA) gene, and an insertion, deletion or mutation in the gene or locus designated F3, wherein: the vaccinia virus is an LIVP strain; each of the TK, HA and F3 gene or locus is inactivated; and the F3 gene or locus occurs on the HindIII-F fragment of the LIVP strain of vaccinia virus between open reading frames F14L and F15L.