Patent ID: 7229997

Claim:
A compound of the formula (I): wherein R 1 is selected from H, C 1-4 alkyl, 2-hydroxyethyl, 2-cyanoethyl, and tetrahydropyran-2-yl; R 2 and R 3 each, independently, represent H or CH 3 ; R 4 is selected from O—R 5 , NH—R 5 or S—R 5 , wherein R 5 is selected from aryl, aryl-C 1-6 -alkyl, aryloxy-C 2-6 -alkyl, heteroaryl, heteroaryl-C 1-6 -alkyl, heteroaryloxy-C 2-6 -alkyl, C 3-6 -cycloalkyl, C 3-6 -cycloalkyl-C 1-4 -alkyl, C 1-6 -alkyl, 2-tetrahydrofuryl, 3-tetrahydrofuryl, 2-tetrahydrofurfuryl, 3-tetrahydrofurfuryl, piperidine-4-yl, tetrahydropyran-4-yl, C 3-6 -alkynyl, C 3-6 -alkenyl, or fluoro-C 2-4 -alkyl; and wherein any aryl or heteroaryl residue, alone or as part of another group, may be unsubstituted or substituted with one or more of C 1-4 -alkyl, C 1-4 -alkoxy, C 1-4 -alkylthio, C 2-4 -acyl, C 1-4 -alkylsulphonyl, cyano, nitro, hydroxy, C 2-6 -alkenyl, C 2-6 -alkynyl, fluoromethyl, trifluoromethyl, trifluoromethoxy, halogen, —N(R 6 )(R 7 ), aryl, aryloxy, arylthio, aryl-C 1-4 -alkyl, aryl-C 2-4 -alkenyl, aryl-C 2-4 -alkynyl, heteroaryl, heteroaryloxy, heteroarylthio, heteroaryl-C 1-4 -alkyl, aryl-C 1-4 -alkoxy, aryloxy-C 1-4 -alkyl, or dimethylamino-C 2-4 -alkoxy, wherein R 6 and R 7 are, independently of each other, hydrogen, methyl or ethyl; or form a pyrrolidine, piperazine, morpholine, thiomorpholine or a piperidine ring together with the nitrogen atom to which they are bound; and wherein any aryl or heteroaryl residue as substituents on aryl or heteroaryl, alone or as part of another group, in turn may be substituted in one or more positions independently of each other by C 1-4 -alkyl, C 1-4 -alkoxy, halogen, trifluoromethyl, cyano, hydroxy or dimethylamino; and pharmaceutically acceptable salts, hydrates, geometrical isomers, tautomers, optical isomers, and N-oxides thereof.