Patent ID: 8075916

Claim:
A poly(organophosphazene) represented by Chemical Formula 1a: wherein p is the number of repeating units of ethylene glycol ranging from 7 to 50; NHCH(R 1 )CO 2 R 2 is a hydrophobic amino acid ester, wherein R 1 is selected from the group consisting of H, CH 3 , CH 2 SH, CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )C 2 H 5 , CH 2 CH 2 SCH 3 , CH 2 C 6 H 5 , CH 2 C 6 H 4 OH, and CH 2 C 2 H 2 C 6 H 4 , and R 2 is selected from the group consisting of CH 3 , C 2 H 5 , C 3 H 7 , C 4 H 9 , CH 2 C 6 H 5 , and CH 2 CHCH 2 ; NH(R 3 )(R 4 )(R 5 ) is an amino acid, peptide, or depsipeptide ester, wherein R 3 is CH(W), R 4 is selected from the group consisting of CO 2 , CO 2 CH 2 CO 2 , CO 2 CH(CH 3 )CO 2 , and CONHCH(X)CO 2 , R 5 is selected from the group consisting of H, CH 3 , and C 2 H 5 , and W and X are independently selected from the group consisting of H, HCH 2 , CH 3 , CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )C 2 H 5 , CH 2 CH 2 SCH 3 , CH 2 C 6 H 5 , CH 2 C 2 NH 2 C 6 H 4 , CO 2 C 2 H 5 , (CH 2 ) 2 CO 2 C 2 H 5 , CH 2 OH, CH(CH 3 )OH, CH 2 C 6 H 4 OH, CH 2 COOH, CH 2 CH 2 COOH, CH 2 CONH 2 , C 4 H 8 NH 2 , C 3 H 6 NHC(═NH)NH 2 , CH 2 C 3 N 2 H 3 , and CH 2 SH; NH(R 6 )(R 7 )(R 8 ) and NH(R 6 )(R 7 )(R 9 ) are substituents having a functional group, wherein R 6 is CH(Y), R 7 is selected from the group consisting of CH 2 , C 2 H 4 CO 2 , CONHCH(Z)CONHCH(M)O, CONHCH(Z)CONHCH(L)CONHCH(L)O, CONHCH(Z)CONHCH(M)S, CONHCH(Z)CONHCH(M)CONHCH(L)S, CONHCH(Z)CONHCH(M)N, CONHCH(Z)CONHCH(M)CONHCH(L)N, COCHNH(Z)CONHCH(M)CON, COCHNH(Z)CONHCH(M)CONHCH(L)CON, COCHNH(Z)CONHCH(M)CO, COCHNH(Z)CONHCH(M)CONHCH(L)CO, COCHNH(Z)CONHCH(M)CO 2 , and COCHNH(Z)CONHCH(M)CONHCH(L)CO 2 , R 8 is selected from the group consisting of OH, SH, H, CH 3 , C 2 H 5 , C 3 H 7 , C 4 H 9 , CH 2 C 6 H 5 CH 2 CHCH 2 , and a protecting group, Y, Z, L, and M are independently selected from the group consisting of H, HCH 2 , CH 3 , CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )C 2 H 5 , CH 2 CH 2 SCH 3 , CH 2 C 6 H 5 , CH 2 C 2 NH 2 C 6 H 4 , CO 2 C 2 H 5 , (CH 2 ) 2 CO 2 C 2 H 5 , CH 2 OH, CH(CH 3 )OH, CH 2 C 6 H 4 OH, CH 2 COOH, CH 2 CH 2 COOH, CH 2 CONH 2 , C 4 H 8 NH 2 , C 3 H 6 NHC(═NH)NH 2 , CH 2 C 3 N 2 H 3 , and CH 2 SH, R 9 is selected from the group consisting of OH, SH, H, NH 2 , CH 3 , C 2 H 5 , C 3 H 7 , C 4 H 9 , CH 2 C 6 H 5 , CH 2 CHCH 2 , NHCH(SH)CO 2 H, NH(CH 2 ) q SH, NH(CH 2 CH 2 NH) r H, [NHCH(C 4 H 8 NH 2 )CO] r OH, [NHCH[(CH 2 ) 3 C(═NH)(NH 2 )]CO] r OH, folic acid, hyaluronic acid, polyhistidine, cyclodextrin, heparin, chitosan, and protamines, and q is the number of repeating units of methylene ranging from 1 to 20; r is the number of repeating units of ethylenimine, lysine, or arginine, ranging from 1 to 18,000; a 1 , a 2 , b, c, d, and e respectively represent the content of each substituent, wherein a 1 , a 2 , b, and d are independently from 0.01 to 1.9, c and e are independently from 0 to 1.9, and a 1 +a 2 +b+c+d+e=2.0; and n is the degree of polymerization of the poly(organophosphazene) ranging from 5 to 100,000.