Patent ID: 8053410

Claim:
A preparation comprising a Factor VII polypeptide comprising SEQ ID NO: 1, wherein the Factor VII polypeptide has (1) a valine substituted with aspartic acid at position 158 of SEQ ID NO: 1, (2) a glutamic acid substituted with valine at position 296 of SEQ ID NO: 1 and (3) a methionine substituted with glutamine at position 298 of SEQ ID NO: 1, and wherein the Factor VII polypeptide comprises one or more oligosaccharide chains, wherein the oligosaccharide chains are selected from the group consisting of asparagine-linked oligosaccharide chains, serine-linked oligosaccharide chains, and combinations thereof, and wherein at least one of said oligosaccharide chains is covalently attached to at least one polyethylene glycol (PEG).