Patent ID: 6899830

Claim:
A process for preparing compounds of the general formula I which comprises reacting compounds of the general formula II with compounds of the formula R 4 MgX (III) at temperatures below 0° C., where the substituents and variables in the formulae, I, II and III have the following meanings: wherein Z is 0 or 1 wherein X is halogen or R 2 wherein X a is Br, or I wherein A, B, D and E independently of one another are CH, CR 2 , N, P or CR 3 wherein F is O, S, NR 6 , CR 2 , or CR 3 when z=0, or CH, CR 2 , N, P or CR 3 when z=1, wherein two adjacent variables A, B, D, E or F together optionally form another substituted or unsubstituted aromatic saturated or partially saturated ring which has 5 to 8 atoms in the ring and which may contain one or more heteroatoms such as O, N, S, P, and not more than three of the variables, A, B, D, E or F being a heteroatom, wherein R 1 is COOR 2 , CN, CONR 3 R 3 , or Halogen wherein R 2 is substituted or unsubstituted, branched or unbranched C 1 -C 10 -alkyl, C 3 -C 10 -cycloalkyl, C 1 -C 4 -alkylaryl, C 1 -C 4 -alkylhetaryl, or R 5 , wherein R 3 is hydrogen, substituted or unsubstituted, branched or unbranched —OC 1 -C 10 -alkyl, —OC 3 -C 10 -cycloalkyl, —OC 1 -C 4 -alkylaryl, —oC 1 -C 4 -alkylhetaryl, R 3 or R 5 , wherein R 3 is hydrogen, substituted or unsubstituted, branched or unbranched C 1 -C 10 -alkyl, C 3 -C 10 -cycloalkyl, C 1 -C 4 -alkylaryl, C 1 -C 4 -alkylhetaryl, or R 5 , wherein R 4 is substituted or unsubstituted, branced or unbranched C 1 -C 10 -alkyl, C 3 -C 10 -cycloalkyl, C 1 -C 4 -alkylaryl, C 1 -C 4 -alkylhetaryl, or halogen, wherein R 5 is a solid support, wherein R 6 is substituted or unsubstituted, branched or unbranched C 1 -C 10 -alkyl, C 3 -C 10 -cycloalkyl, C 1 -C 4 -alkylaryl, C 1 -C 4 -alkylhetaryl, substituted or unsubstituted, branched or unbranched —(C═O)—C 1 -C 10 -alkyl, —(C═O)—C 3 -C 10 -cycloalkyl, —(C═O)—C 1 -C 4 -alkylaryl, —(C═O)—C 1 -C 4 -alkylhetaryl or —SO 2 —aryl where the process is caried out on a solid support (R 5 ).