Patent ID: 7304076

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein: X is independently N or C; Z is independently NR 8 ; D is independently H, —OH, -alkyl or substituted -alkyl with the proviso that when X is N, D and the X-D bond are absent; E is independently H, -alkyl or substituted -alkyl, or D and E can independently be joined together via a —(CH 2 ) p -bridge; Q is independently H, -alkyl or substituted -alkyl, or D, X, Q and the carbon to which Q is attached can jointly form a 3 to 7-membered ring; g, j, k, m and n can be the same or different and are independently selected; g is 0; j and k are independently 0 to 3 such that the sum of j and k is 0, 1, 2 or 3; m and n are independently 0 to 3 such that the sum of m and n is 1, 2, 3, 4 or 5; p is 1 to 3; R 1 is 1 to 5 substituents which can be the same or different, each R 1 being independently selected from the group consisting of hydrogen, hydroxy, halogen, haloalkyl, -alkyl, substituted -alkyl, -cycloalkyl, CN, alkoxy, cycloalkoxy, alkylthio, cycloalkylthio, —NR 5 R 6 , —NO 2 , —CONR 5 R 6 , —NR 5 COR 6 , —NR 5 CONR 5 R 6 where the two R 5 moieties can be the same or different, —NR 6 C(O)OR 7 , —C(O)OR 6 , —SOR 7 , —SO 2 R 7 , —SO 2 NR 5 R 6 , aryl and heteroaryl; R 2 is 1 to 6 substituents which can be the same or different, each R 2 being independently selected from the group consisting of hydrogen, -alkyl, substituted -alkyl, alkoxy, and hydroxy, with the proviso that when X is N and R 2 is hydroxy or alkoxy, R 2 is not directly attached to a carbon adjacent to X; R 3 is independently hydrogen, -alkyl or substituted -alkyl; R 4 is 1 to 6 substituents which can be the same or different, each R 4 being independently selected from hydrogen, -alkyl, substituted -alkyl, alkoxy, and hydroxy, with the proviso that when Z is NR 8 and R 4 is hydroxy or alkoxy, R 4 is not directly attached to a carbon adjacent to the NR 8 ; R 5 and R 6 are independently hydrogen, -alkyl, substituted -alkyl or -cycloalkyl; R 7 is independently -alkyl, substituted -alkyl or -cycloalkyl; R 8 is independently selected from the group consisting of hydrogen, -alkyl, substituted -alkyl, -cycloalkyl, -alkylcycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, —SO 2 R 10 , —SO 2 NR 5 R 11 , —C(O)R 11 , —C(O)NR 5 R 11 and —C(O)OR 10 ; R 9 is independently hydrogen, -alkyl, substituted -alkyl, hydroxy, alkoxy, —NR 5 R 11 , aryl, or heteroaryl; or R 3 and R 9 can be joined together and with the carbon to which they are attached form a carbocyclic or heterocyclic ring having 3 to 7 ring atoms; R 10 is -alkyl, substituted -alkyl, -cycloalkyl, -alkylcycloalkyl, aryl or heteroaryl; and R 11 is independently hydrogen, -alkyl, substituted -alkyl, -cycloalkyl, aryl or heteroaryl.