Patent ID: 8153686

Claim:
A compound of formula (I): wherein R 1 is —OR a or —C(O)NR b R c ; R 2 , R 3 , and R 4 are each independently C 1-3 alkyl; R 5 is selected from hydrogen, —CH 2 -cyclohexyl, benzyl, —CH 2 OH, and —C(O)OH; R 6 is hydrogen or C 1-3 alkyl; R 7 is selected from hydrogen, —C(O)R 8 , —C(O)NHR 9 , —C(S)NHR 10 , —S(O) 2 R 11 , and C 1-6 alkyl, optionally substituted with —C(O)NH 2 , —OH, —CN, —O(CH 2 ) 2 OCH 3 , cyclohexyl, or phenyl, wherein cyclohexyl and phenyl are each optionally substituted with one or two halo; R 8 is selected from phenyl, benzyl, C 5-6 cycloalkyl, furanyl, thiophenyl, and C 1-6 alkyl, wherein phenyl, benzyl, and C 5-6 cycloalkyl are optionally substituted with one or two halo or with —S(O) 2 NH 2 , and C 1-6 alkyl is optionally substituted with one or two substituents selected from —OH, —C(O)OR a , —C(O)NH 2 , —S(O) 2 CH 3 , phenyl, and —OCH 2 OCH 3 ; R 9 is selected from C 1-6 alkyl, phenyl, benzyl, and —CH 2 -cyclohexyl, wherein phenyl and benzyl are each optionally substituted with one or two substituents selected from halo, —OCH 3 , and —CF 3 ; R 10 is selected from C 1-6 alkyl, phenyl, and benzyl, wherein phenyl and benzyl are each optionally substituted with one or two halo; R 11 is selected from C 1-6 alkyl, cyclohexyl, and phenyl, wherein phenyl is optionally substituted with —NHC(O)CH 3 or with from 1 to 5 fluoro; R a , R b , and R c are each independently hydrogen or C 1-3 alkyl; and n is 0 or 1; wherein the substituents at the chiral centers marked by asterisks are in the trans configuration; provided that when R 1 is —OR a , then at least one of R 5 and R 7 is not hydrogen or C 1-6 alkyl; or a pharmaceutically-acceptable salt thereof.