Patent ID: 8383655

Claim:
A method for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase, comprising administering to a patient treated with the drug a therapeutically effective amount of a compound of formula IID, or a pharmaceutically acceptable salt thereof, wherein, L 1 is selected from the group consisting of —C(R 6 ) 2 —, —C(O)—, —S(O 2 )—, —N(R 7 )—C(O)—, and —O—C(O)—; each L 3 is independently a covalent bond, alkylene, or substituted alkylene; each L 4 is independently selected from the group consisting of a covalent bond, alkylene, substituted alkylene, —O—, —CH 2 —O—, and —NH—; each A is independently selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl, with the proviso that when A is H, p is 0; Z 1 and Z 2 are each independently —O— or —N(R 7 )—; Y and X are each independently selected from the group consisting of heterocyclyl and heterocyclylalkyl; each Ar is independently selected from the group consisting of aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 1 , R 3 , and R 5 are each independently selected from the group consisting of H, alkyl, substituted alkyl, arylalkyl, and substituted arylalkyl; R 2 is independently selected from the group consisting of H, alkyl, substituted alkyl, alkoxyalkyl, hydroxyalkyl, arylheteroalkyl, substituted arylheteroalkyl, arylalkyl, substituted arylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, aminoalkyl, substituted aminoalkyl, -alkylene-C(O)—OH, -alkylene-C(O)—Oalkyl, -alkylene-C(O)amino, and -alkylene-C(O)-alkyl; R 4 and R 6 are each independently selected from the group consisting of H, alkyl, substituted alkyl, and heteroalkyl; each R 7 is independently selected from the group consisting of H, alkyl, substituted alkyl, heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, and substituted heterocyclyl; R 8 and R 9 are each one or more substituents independently selected from the group consisting of H, alkyl, substituted alkyl, halogen, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, and —CN; and each p is independently 0 or 1.