Patent ID: 8609649

Claim:
A method of treating a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of a compound of formula I, III, IV, V, VI, VII, VIII, IX, X, or XI, or a pharmaceutically acceptable salt thereof, wherein the neurodegenerative disease is Alzheimer's disease, Parkinson's disease, or Amyotrophic lateral sclerosis; the compound of formula I is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; and R′ is hydrogen or lower alkyl; the compound of formula III is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; and R′ is hydrogen or lower alkyl; the compound of formula IV is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; R′ is hydrogen or lower alkyl; and R″ is hydrogen, lower alkyl, or the two occurrences of R″ taken together are —CH 2 [CH 2 ] 2 CH 2 —, —CH 2 [CH 2 ] 3 CH 2 —, —CH 2 [CH 2 ] 4 CH 2 — or —CH 2 [CH 2 ] 5 CH 2 —; the compound of formula V is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; R 1 is hydrogen or lower alkyl; R 2 is hydrogen, nitro or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen or lower alkyl; and R 5 is hydrogen or lower alkyl; the compound of formula VI is represented by: wherein, independently for each occurrence, X is hydrogen or —CH 2 OR; R is hydrogen or lower alkyl; R 1 is hydrogen or lower alkyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl, —Cl, —OR, or NR 2 ; R 4 is hydrogen or lower alkyl; and R 5 is hydrogen, —Cl, or lower alkyl; the compound of formula VII is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; and R″ is hydrogen or lower alkyl; the compound of formula VIII is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; R″ is hydrogen or lower alkyl; R 1 is hydrogen or lower alkyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl, —Cl, or —OR; R 4 is hydrogen, lower alkyl, —Cl, or —OR; and R 5 is hydrogen, —Cl, or lower alkyl; the compound of formula IX is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; and R″ is hydrogen or lower alkyl; the compound of formula X is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; R′ is hydrogen or lower alkyl; and R″ is hydrogen or lower alkyl; and the compound of formula VI is represented by: wherein, independently for each occurrence, R is hydrogen or lower alkyl; and R″ is hydrogen or lower alkyl.