Patent ID: 7361671

Claim:
A compound of the formula D-A-C(O)R′ or a pharmaceutically acceptable salt thereof wherein D represents where Y is -Z-Ar where Z is a bond, O, S, C(O)NH, or C 1 -C 6 alkylene optionally substituted with C 1 -C 2 alkyl; and Ar represents benzothiazolyl or benzothiazolyl(C 1 -C 6 )alkyl, where the benzothiazolyl portion is optionally substituted by one, two or three groups independently selected from (1) halogen, (C 1 -C 6 )alkyl, hydroxy, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloacetyl, cyano, nitro, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, OR 27 , SR 27 , S(O)R 27 , S(O) 2 R 27 and N(R 27 ) 2 wherein each R 27 is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 haloalkoxy; and (2) phenyl, pyridyl, furyl, and thienyl, each of which is optionally substituted with one, two, or three groups independently selected from halogen, (C 1 -C 6 )alkyl, hydroxy, halogen, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloacetyl, cyano, nitro, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, OR 37 , SR 37 , S(O) R 37 , S(O)2R 37 and N(R 37 ) 2 wherein each R 37 is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 haloalkoxy; R 3 is hydrogen, halogen, hydroxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, aryl, —SR 15 or —OR 15 , where R 15 is (C 1 -C 6 )alkyl, aryl, or aryl(C 1 -C 6 )alkyl where each aryl is optionally mono-, di-, or trisubstituted with halogen, (C 1 -C 6 )alkyl, hydroxy, halogen, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloacetyl, cyano, nitro, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, OR 7 , SR 7 , S(O)R 7 , S(O) 2 R 7 , and N(R 7 ) 2 , R 5 represents hydrogen, halogen, hydroxy, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, hydroxy, amino, mono or di(C 1 -C 6 )alkylamino, or aryl where aryl is optionally substituted with up to three groups independently selected from halogen, (C 1 -C 6 )alkyl, hydroxy, halogen, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )haloacetyl, cyano, nitro, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, OR 7 , SR 7 , S(O)R 7 , S(O) 2 R 7 and N(R 7 ) 2 ; each R 7 is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 haloalkoxy; A is a C 1 -C 4 alkylene group optionally substituted with C 1 -C 2 alkyl or mono- or disubstituted with halogen; and R′ is hydroxy, benzyloxy, di(C 1 -C 6 )alkylaminoethyloxy, acetoxymethyl, pivaloyloxymethyl, phthalidoyl, ethoxycarbonyloxyethyl, 5-methyl-2-oxo-1,3-dioxol-4-yl methyl, or (C 1 -C 6 )alkoxy optionally substituted by N-morpholino or di(C 1 -C 6 )alkylamino.