Patent ID: 7186741

Claim:
A compound of the formula (1) wherein, S 1 is chosen from hydrogen, halogen, hydroxy and alkoxy (1–3C); S 2 is chosen from hydrogen and halogen; S 3 is chosen from hydrogen, halogen, hydroxy and alkoxy (1–3C); S 4 is chosen from hydrogen, halogen and alkyl (1–6C) optionally substituted with hydroxy, alkoxy (1–3C), amino, mono- or dialkylamino having 1–3C-atoms in the alkyl group(s), SH or S-alkyl (1–3C); X is chosen from nitrogen and carbon; Y is chosen from nitrogen and oxygen when X is nitrogen, or Y is nitrogen when X is carbon; R 3 and R 4 , which may be identical or different, are chosen from hydrogen and alkyl (1–3C); R 5 is chosen from hydrogen and alkyl (1–6C) which may be substituted with halogen, CN, CF 3 , hydroxy, alkoxy (1–3C), sulfonylalkyl (1–3C), amino, mono- or dialkylamino having 1–3C-atoms in the alkyl group(s) when X is carbon or nitrogen, or R 5 represents alkoxy (1–6C), SH or S-alkyl (1–3C) when X is carbon; R′ 5 is chosen from hydrogen and alkyl (1–3C); R 6 is chosen from hydrogen, and alkyl (1–3C); R 7 is chosen from hydrogen and alkyl (1–3C); or R 5 and R 6 together or R′ 5 and R 6 together can form a 3–7 membered cyclic group which is optionally substituted with a group chosen from lower alkyl, halogen, CN and CF 3 , and R 5 +R′ 5 together optionally form a 3–7 membered ring; Z 1 , Z 2 and Z 3 are chosen from carbon, or Z 1 is nitrogen and Z 2 and Z 3 are carbon, or Z 1 and Z 3 are carbon and Z 2 is nitrogen, or Z 1 and Z 2 are carbon and Z 3 is nitrogen; A is chosen from a (poly) cycloalkyl system comprising 4–10 membered rings which are optionally substituted with a group chosen from halogen, CF 3 , alkyl or alkoxy (1–3C), CN, OH and SH; and pharmacologically acceptable salts thereof.