Patent ID: 7186682

Claim:
An isolated polypeptide capable of binding to the intracellular domain of a p55 TNF receptor, comprising: (a) the sequence of SEQ ID NO:14; (b) an analog of (a) having a deletion, addition or substitution of a single amino acid, which analog maintains the capability of binding to the intracellular domain of a p55 TNF receptor; (c) a fraction of (a) or (b), which fraction maintains the capability of binding to the intracellular domain of a p55 TNF receptor; or (d) a salt of (a), (b) or (c) or a functional derivative of (a), (b) or (c), which functional derivative comprises aliphatic esters or amides of the carboxyl groups on the side chains or C-terminus thereof, or N-acyl derivatives of free amino groups on the side chains or N-terminus thereof, or O-acyl derivatives of free hydroxyl groups on the side chains or C-terminus thereof, or a conjugate of the polypeptide to another molecule, which salt or functional derivative maintains the capability of binding to the intracellular domain of a p55 TNF receptor.