Patent ID: 7345196

Claim:
A process to manufacture α-Difluoromethylornithine, its analogs and derivatives represented by formula I wherein R 1 is hydrogen; R 2 is hydroxy, C 1 -C 8 alkoxy, or C 1 -C 8 —NR′R″, wherein R′ and R″ are independently hydrogen, or C 1 -C 8 alkyl groups; R 3 is hydrogen; R 4 is —CH 2 F, —CHF 2 , or —CF 3 , and the salts thereof, and the process comprising the step of hydrolyzing the holomethylated compounds IIIa, under acid conditions, wherein R 4 is as described above; R 8 is hydrogen, or C 1 -C 8 alkyl; R 9 is a halogen; a dihalogen; poly alkoxy; or m-nitro; and R 10 is a halogen; a dihalogen; poly alkoxy; or m-nitro.