Patent ID: 7323449

Claim:
A compound of the structural formula I: or a pharmaceutically acceptable salt thereof; wherein R 1 is C 1-4 alkyl, wherein alkyl is unsubstituted or substituted with hydroxy, amino, C 1-4 alkoxy, C 1-4 alkylthio, or one to three fluorine atoms; R 2 is amino, fluorine, hydroxy, mercapto, C 1-4 alkoxy, or C 1-10 alkylcarbonyloxy; R 3 and R 4 are each independently selected from the group consisting of hydrogen, cyano, azido, halogen, hydroxy, mercapto, amino, C 1-4 alkoxy, C 1-10 alkylcarbonyloxy, C 2-4 alkenyl, C 2-4 alkynyl, and C 1-4 alkyl, wherein alkyl is unsubstituted or substituted with hydroxy, amino, C 1-4 alkoxy, C 1-4 alkylthio, or one to three fluorine atoms; R 5 is hydrogen, C 1-10 alkylcarbonyl, P 3 O 9 H 4 , P 2 O 6 H 3 , or P(O)R 13 R 14 ; R 6 and R 7 are each independently hydrogen, methyl, hydroxymethyl, or fluoromethyl; R 8 is hydrogen, C 1-4 alkyl, C 2-4 alkynyl, halogen, cyano, carboxy, C 1-4 alkyloxycarbonyl, azido, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, hydroxy, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, or (C 1-4 alkyl) 0-2 aminomethyl; R 9 is hydrogen, nitro, C 1-3 alkyl, NHCONH 2 , CONR 12 R 12 , CSNR 12 R 12 , COOR 12 , C(═NH)NH 2 , hydroxy, C 1-3 alkoxy, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, halogen, (1,3-oxazol-2-yl), (1,3-thiazol-2-yl), or (imidazol-2-yl); wherein alkyl is unsubstituted or substituted with one to three groups independently selected from halogen, amino, hydroxy, carboxy, and C 1-3 alkoxy; R 10 and R 11 are each independently hydrogen, hydroxy, halogen, C 1-4 alkoxy, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 3-6 cycloalkylamino, di(C 3-6 cycloalkyl)amino, or C 4-6 cycloheteroalkyl, unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, amino, C 1-4 alkyl, and C 1-4 alkoxy; each R 12 is independently hydrogen or C 1-6 alkyl; and R 13 and R 14 are each independently hydroxy, OCH 2 CH 2 SC(═O)C 1-4 alkyl, OCH 2 O(C═O)OC 1-4 alkyl, NHCHMeCO 2 Me, OCH(C 1-4 alkyl)O(C═O)C 1-4 alkyl,