Patent ID: 7402393

Claim:
A method of screening for an antagonist that blocks the binding of an APM1 polypeptide or an APM1 polypeptide fragment to a GZIP polypeptide comprising: a) contacting the APM1 polypeptide comprising SEQ ID NO:4, or an APM1 polypeptide fragment comprising amino acids 108-244 of SEQ ID NO:4 with a GZIP polypeptide comprising amino acids 21-298 of SEQ ID NO:2 in the presence and absence of a test compound; b) detecting binding of the GZIP polypeptide comprising amino acids 21-298 of SEQ ID NO:2 to the APM1 polypeptide according to SEQ ID NO:4, or an APM1 polypeptide fragment comprising amino acids 108-244 of SEQ ID NO:4 in the presence or absence of a test compound; and c) identifying a test compound as an antagonist of GZIP/APM1 interaction if the binding of APM1 to GZIP is blocked in the presence of said test compound.