Patent ID: 7419789

Claim:
A method of inhibiting binding of a Dengue virus to a human cell, wherein the binding of the Dengue virus to the human cell is mediated at least in part by the binding of a Dengue virus effector molecule on the Dengue virus to one or more DC-SIGN receptor selected from DC-Specific ICAM-Grabbing Nonintegrin (DC-SIGN) and DC-Specific ICAM-Grabbing Nonintegrin Related (DC-SIGNR) expressed on the human cell, the method comprising: providing to the human cell a molecule that specifically binds to the DC-SIGN receptor; wherein the molecule that specifically binds to the DC-SIGN receptor is provided in an amount sufficient to inhibit the binding of the Dengue virus effector molecule to the DC-SIGN receptor to thereby inhibit binding of the Dengue virus to the human cell; and wherein the molecule that specifically binds to the DC-SIGN receptor is an antibody.