Patent ID: 8003625

Claim:
A compound of formula (I): wherein Y 2 is O, S, NR 6 , NCOR 6 , or NSO 2 R 6 wherein R 6 is (C 1 -C 6 ) alkyl, C 1 -C 6 heteroalkyl, aryl, or heteroaryl; R 3 and R 4 are independently selected from the group consisting of 2-haloalkyl, 2-alkylsulfonyloxyalkyl, 2-heteroalkylsulfonyloxyalkyl, 2-arylsulfonyloxyalkyl, and 2-heteroalkylsulfonyloxyalkyl; R 1 has the formula L-Z 3 ; L is C(Z 1 ) 2 ; and each Z 1 independently is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, aryl, heteroaryl, C 3 -C 8 cycloalkyl, heterocyclyl, C 1 -C 6 acyl, C 1 -C 6 heteroacyl, aroyl, or heteroaroyl; or L is: Z 3 is a bioreductive group having a formula selected from the group consisting of: each X 1 is independently N or CR 8 ; X 2 is NR 7 , S, or O; R 7 is independently selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 3 -C 8 cycloalkyl, heterocyclyl, aryl and heteroaryl; R 8 is independently hydrogen, halogen, cyano, CHF 2 , CF 3 , CO 2 H, amino, C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, aryl, CON(R 7 ) 2 , C 1 -C 6 acyl, C 1 -C 6 heteroacyl, aroyl or heteroaroyl; or a pharmaceutically acceptable salt thereof.