Patent ID: 8796436

Claim:
An iRNA agent comprising a first strand and a second strand, wherein at least two subunits having a formula (I) are incorporated into at least one of said strands: wherein: X is N(CO)R 7 , NR 7 or CH 2 ; Y is NR 8 , O, S, CR 9 R 10 , or absent; Z is CR 11 R 12 or absent; each of R 1 , R 2 , R 3 , R 4 , R 9 , and R 10 is, independently, H, OR a , OR b , (CH 2 ) n OR a , or (CH 2 ) n OR b , provided that at least one of R 1 , R 2 , R 3 , R 4 , R 9 , and R 10 is OR a or OR b and that at least one of R 1 , R 2 , R 3 , R 4 , R 9 , and R 10 is (CH 2 ) n OR a , or (CH 2 ) n OR b ; each of R 5 , R 6 , R 11 , and R 12 is, independently, H, C 1 -C 6 alkyl optionally substituted with 1-3 R 13 , or C(O)NHR 7 ; or R 5 and R 11 together are C 3 -C 8 cycloalkyl optionally substituted with R 14 ; R 7 is R d ; or C 1 -C 20 alkyl substituted with NR c R d or NHC(O)R d ; R 8 is C 1 -C 6 alkyl; R 13 is hydroxy, C 1 -C 4 alkoxy, or halo; R 14 is NR c R 7 ; R a is H or R b is H or wherein the Strand in each occurrence is independently the first strand or second strand of the iRNA agent; each of A and C is, independently, O or S; and B is OH, O − , or R c is H or C 1 -C 6 alkyl; R d is H or a ligand; and n is 1-4.