Patent ID: 6982265

Claim:
A compound of formula I its enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X and Y are independently O, OCO, S, SO SO 2 , CO, CO 2 , NR 10 , NR 11 CO, NR 12 CONR 13 , NR 14 CO 2 , NR 15 SO 2 , NR 15 SO 2 , NR 16 SO 2 NR 17 , SO 2 NR 18 , CONR 19 , halogen, nitro, cyano, or X or Y are absent; Z is O, S, N, or CR 20 ; R 1 is hydrogen, CH 3 , OH, OCH 3 , SH, SCH 3 , OCOR 21 , SOR 22 , SO 2 R 23 , SO 2 NR 24 R 25 , CO 2 R 26 , CONR 27 R 28 , NH 2 , NR 29 SO 2 NR 30 R 31 , NR 32 SO 2 R 33 , NR 34 COR 35 , NR 36 CO 2 R 37 , NR 38 CONR 39 R 40 , halogen, nitro, or cyano; R 2 and R 3 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, substituted aralkyl, heterocycloalkyl or substituted heterocycloalkyl, or when X is halo, nitro or cyano R 2 is absent or when Y is halo, nitro or cyano R 3 is absent; R 4 is alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, substituted aralkyl; R 5 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, or substituted aralkyl; or R 4 and R 5 may together form an optionally substituted monocyclic 5–7 membered saturated or unsaturated carbocyclic or heterocyclic ring, or an optionally substituted bicyclic 7–11 membered saturated or unsaturated heterocyclic ring, except that when Z is O or S, R 5 is absent; R 6 is hydrogen, alkyl, substituted alkyl, substituted aryl, heterocyclo, substituted heterocyclo, NR 7 R 8 , OR 9 or halogen; R 7 is selected from the group consisting of hydrogen, C 2 –C 20 alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo, R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 21 , R 24 , R 25 , R 26 , R 27 , R 28 , R 29 , R 30 , R 31 , R 32 , R 34 , R 35 , R 36 , R 38 , R 39 and R 40 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo, R 22 , R 23 , R 33 and R 37 are independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo; and R 20 is selected from the group consisting of hydrogen, lower alkyl and substituted alkyl, or R 20 is absent if the carbon to which it is attached is part of an unsaturated aryl or heteroaryl ring; with the provisos that: a. R 2 may not be hydrogen if X is SO, SO 2 , NR 13 CO 2 , or NR 14 SO 2 , b. R 3 may not be hydrogen if Y is SO, SO 2 , NR 13 CO 2 , or NR 14 SO 2 .