Patent ID: 7582765

Claim:
A method of treating a pulmonary disease in a mammal, wherein the pulmonary disease is asthma or chronic obstructive pulmonary disease, the method comprising administering to the mammal a therapeutically-effective amount of a compound of formula (IIa): wherein: R 4 is —CH 2 OH or —NHCHO and R 5 is hydrogen; or R 4 and R 5 taken together are —NHC(═O)CH═CH—; R 11 is phenyl or heteroaryl, wherein each phenyl is optionally substituted with 1 or 2 substituents selected from halo, —OR d , —CN, —NO 2 , —SO 2 R d , —C(═O)R d , —C(═O)NR d R e , and C 1-3 alkyl, wherein C 1-3 alkyl is optionally substituted with 1 or 2 substituents selected from carboxy, hydroxy, and amino, and each R d and R e is independently hydrogen or C 1-3 alkyl; and wherein each heteroaryl is optionally substituted with 1 or 2 C 1-3 alkyl substituents; and R 12 is hydrogen or —OC 1-6 alkyl; or a pharmaceutically-acceptable salt or stereoisomer thereof; and a therapeutically-effective amount of a corticosteroid selected from 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-[(4-methyl-1,3-thiazole-5-carbonyl)oxy]-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester and 6α,9α-difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester.