Patent ID: 7351818

Claim:
A DNA molecule that can be transcribed to provide an RNA molecule having an untranslated region that provides an increased efficiency of translation of a therapeutic polypeptide in vivo when operably linked to a region encoding said polypeptide; wherein said DNA molecule (i) does not encode a mammalian Hsp70 (ii) does not comprise an hsp promoter; and (iii) comprises (a) the sequence: 5′ataacggctagcctgaggagctgctgcgacagtccactacctttttc gagagtgactcccgttgtcccaaggcttcccagagcgaacctgtgcggct gcaggcaccggcgcgtcgagtttccggcgtccggaaggaccgagctcttc tcgcggatccagtgttccgtttccagcccccaatctcagagccgagccga cagagagcagggaaccgc-3′ (SEQ ID NO: 1), (b) the complement of the sequence given in (a), or (c) a sequence having sequence identity of at least 90% with a sequence as defined in (a) or (b) above.