Patent ID: 7776107

Claim:
At least one chemical entity chosen from aminoindolizines of formula (I) acid addition salts thereof, and solvates thereof: wherein R 1 is a radical chosen from: linear and branched C 1 -C 10 alkyl radicals optionally substituted by at least one group chosen from OH and OR 19 , wherein R 19 is chosen from linear and branched C 1 -C 6 alkyl radicals optionally substituted by at least one OH radical, sulphur-containing radicals chosen from SR and SO 2 Me, R being chosen from linear and branched C 1 -C 6 alkyl radicals and aryl radicals, nitrogen-containing radicals chosen from NH 2 , NHR 7 and NR 7 R 8 , wherein R 7 and R 8 , which are identical or different, are chosen from linear and branched C 1 -C 6 alkyl radicals optionally substituted by at least one entity chosen from hydroxyl, amino, C 1 -C 6 mono- and dialkylamino, carboxamido, ureido and guanidinyl groups, and optionally interrupted by an oxygen atom or at least one N(R 13 ), R 13 being chosen from a hydrogen atom and C 1 -C 6 alkyl radicals, it being possible for the radicals R 7 and R 8 to form, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle containing 5 to 7 ring members, radicals OR 9 , R 9 being chosen from linear and branched C 1 -C 6 alkyl radicals optionally substituted by at least one OH radical, and from linear and branched C 1 -C 6 alkoxy radicals, radicals chosen from COOH, CONH 2 , CONHR 11 and CONR 11 R 12 , wherein R 11 and R 12 , which are identical or different, are chosen from linear and branched C 1 -C 6 alkyl radicals optionally interrupted by at least one N(R 14 ), R 14 being chosen from a hydrogen atom and C 1 -C 6 alkyl radicals optionally substituted by a hydroxyl group, it being possible for the radicals R 11 and R 12 to form, together and with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle containing 5 to 7 ring members, R 2 is a radical chosen from: linear and branched C 1 -C 6 alkyl radicals, hydrogen atoms, radicals chosen from COOH, CN, CF 3 and alkoxycarbonyl COOR 10 , R 10 being chosen from linear and branched C 1 -C 6 alkyl radicals, and aryl and heteroaryl radicals, radicals chosen from CONH 2 , CONHR 11 and CONR 11 R 12 , radicals OR 9 , and radicals SR, SOR and SO 2 R, wherein R, R 9 , R 11 and R 12 are as defined above, R 3 , R 4 , R 5 and R 6 , independently of one another, are chosen from: aryl, heteroaryl and linear and branched C 1 -C 6 alkyl radicals optionally interrupted by at least one entity chosen from N(R 13 ) and oxygen, the radicals OR 9 , hydrogen atoms, halogens chosen from fluorine, chlorine and bromine, nitrogen-containing radicals chosen from NH 2 , NHR 7 and NR 7 R 8 , and COOH and CN radicals and alkoxycarbonyl radicals COOR 10 , wherein R 7 , R 8 , R 9 and R 10 are as defined above, with the proviso that not more than one of the radicals R 1 , R 3 , R 4 , R 5 and R 6 is a nitrogen-containing radical chosen from NH 2 , NHR 7 and NR 7 R 8 .