Patent ID: 8795970

Claim:
A method for monitoring an autoimmune disease, an infections disease or a cancer of an individual comprising: (a) obtaining a sample from the individual comprising T-cells and/or B-cells; (b) amplifying molecules of nucleic acid from said cells of the sample, the molecules of nucleic acid comprising sequences of complementarily determining region 3 (CDR3) from T-cell receptor genes or immunoglobulin genes; (c) spatially isolating individual molecules of the amplified nucleic acids; (d) sequencing the spatially isolated individual molecules of the amplified nucleic acids to provide a full repertoire of CDR3 sequences comprising at least 1000 sequence reads of at least 30 bp; and (e) monitoring the autoimmune disease, infectious disease or cancer by determining levels of one or more CDR3 sequences that correlate with the disease or cancer.