Patent ID: 7705030

Claim:
A compound of formula I wherein W is CO, CS or CH 2 ; X is N, NR or CR 9 ; Y is N, NR or CR 10 ; Z is C, N, NR, CR 11 or CR 11 R 12 with the proviso that at least two of X, Y or Z must be N or NR; m is 1 or 2; R is H or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl or ary(C 1 -C 6 )alkyl group each optionally substituted; R 1 and R 2 are each independently H, COR 14 , CO 2 R 15 or an optionally substituted C 1 -C 4 alkyl group; R 3 is H, OR 13 or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl or aryl(C 1 -C 6 )alkyl group each optionally substituted; R 4 , R 5 , R 9 and R 10 are each independently H, halogen, NO 2 , CN, OR 14 , CO 2 R 15 , COR 16 , NR 17 R 18 , SO p NR 19 R 20 or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 3 -C 8 cycloalkyl group each optionally substituted; R 6 and R 8 are each independently H, halogen, NO 2 , CN, OR 21 , NR 22 R 23 or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 3 -C 8 cycloalkyl group each optionally substituted; R 7 is an optionally substituted heteroaryl group; R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 21 , R 24 , R 27 , R 28 and R 29 are each independently H or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, cycloheteroalkyl or aryl group each optionally substituted; R 17 , R 18 , R 19 , R 20 , R 22 , R 23 , R 25 , R 26 , R 30 , R 31 , R 32 and R 33 are each independently H, COR 34 , SO p R 35 or a C 1 -C 4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted or R 17 , R 18 ; or R 19 , R 20 , or R 22 , R 23 , or R 25 , R 26 , or R 30 , R 31 , or R 32 , R 33 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing an additional heteroatom selected from O, N or S; R 34 is H, or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; and R 35 is a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; or a tautomer thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof.