Patent ID: 8404238

Claim:
An isolated huTNFR1-antagonist, comprising a proteinaceous construct comprising a humanized antibody or at least one fragment thereof having (i) one or more amino acid sequences of human origin capable of reducing the immunogenic response of said huTNFR1-antagonist in humans, and (ii) one or more amino acid sequences of non human origin capable of selectively binding to huTNFR1 thereby completely blocking the TNFR1 activity, wherein the proteinaceous construct comprises the amino acid sequence according to SEQ NO.: 7 as variable domain of the heavy chain (VH) and the amino acid sequence according to SEQ ID NO.: 8 as variable domain of the light chain (VL), or a fragment of a humanized antibody, wherein the fragment is a scFv comprising the amino acid sequence according to SEQ ID NO.: 9.