Patent ID: 8847005

Claim:
A mouse comprising at an endogenous Major Histocompatibility Complex (MHC) II gene locus a first nucleotide sequence encoding a chimeric human/mouse MHC II α polypeptide and a second nucleotide sequence encoding a chimeric human/mouse MHC II β polypeptide, wherein a human portion of the chimeric human/mouse MHC II α polypeptide comprises a human MHC II α2 domain and a human portion of the chimeric human/mouse MHC II β polypeptide comprises a human MHC II β2 domain, wherein the first nucleotide sequence is expressed under regulatory control of an MHC II α promoter, and the second nucleotide sequence is expressed under regulatory control of an MHC II β promoter, and wherein the mouse expresses the chimeric human/mouse MHC II α and β polypeptides on the surface of an antigen presenting cell of the mouse.