Patent ID: 8329958

Claim:
A PEG oligomer combinatorial library consisting of three different groups of compounds having structurally diverse amphiphilic block co-polymer oligomers with permutations of number of poly(ethylene glycol) (PEG) monomers and alkyl chains and a conjugation site for binding with a testing drug candidate, the groups consisting of: (a) a first group of oligomers consisting of two or more oligomers having the formula CH 3 (CH 2 ) m —(OCH 2 CH 2 ) n —OH wherein m is 3-17 and n is 1-15, wherein hydrophilic and lipophilic components are connected via a nonhydrolyzable ether bond and a hydroxyl group for subsequent conjugation to the testing drug candidate; (b) a second group of oligomers consisting of two or more oligomers having the formula CH 3 (CH 2 ) m′ —C(O)O—(CH 2 CH 2 O) n′ ,—H wherein m′ is 2-8, 10, 12, 14, and 16 and n′ is 1- 15, wherein hydrophilic and lipophilic components are joined together by a hydrolyzable ester bond and a hydroxyl group for subsequent conjugation to the testing drug candidate; and (c) a third group of oligomers consisting of two or more oligomers having the formula CH 3 (OCH 2 CH 2 ) n″ —O—(CH 2 ) m″ CO 2 H wherein m″ is 4-7, 9-11, 14, and 15 and n″ is 1-11, and 13 wherein hydrophilic and lipophilic components are connected via a nonhydrolyzable ether bond and the hydrophilic and lipophilic components are inverted relative to the first group and a carboxylic acid group for subsequent conjugation to the testing drug candidate; and wherein each compound has a weight of from 2-5 grams and a minimum purity of 90% to provide three different groups for the combinational library for drug discovery.