Patent ID: 7618990

Claim:
A compound of the structure: wherein: R 1 and R 2 are independently, H, C 1 to C 10 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) p —O—(CH 2 ) n -aryl, —(CH 2 ) n C(H) 3−p (R 7 ) p , or —(CH 2 ) n COOR 8 ; R 5 and R 6 are H; or R 1 , R 2 or R 5 , R 6 are taken together to form a carbon-based 3 to 6 membered saturated ring; or R 1 or R 2 forms a carbon-based 5 to 7 membered saturated ring with R 5 or R 6 ; or R 1 or R 2 forms a carbon-based 6-membered aromatic ring with R 5 or R 6 ; R 7 is halogen; R 8 is C 1 to C 6 alkyl; R 9 is H, C 1 to C 6 alkyl, or C 1 to C 3 perfluoroalkyl; V is O or S; X and Z are, independently, N or CR 14 ; R 14 is H, C 1 to C 6 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) n —O—(CH 2 ) n -alkyl, —(CH 2 ) n —O—(CH 2 ) n -aryl, halogen, hydroxy, C 1 to C 3 perfluoroalkyl, C 1 to C 3 perfluoroalkoxy, or —(CH 2 ) n —CN; Y is S; Q is aryl or heteroaryl, each substituted by one or more of R 15 and R 15 is —(CH 2 ) n CN, halogen, NO 2 , —C(NH 2 )═N—OH, C 1 to C 3 perfluoroalkyl, C 1 to C 3 perfluoroalkoxy, —O—(C 1 to C 4 alkyl), —O—(C 1 to C 4 substituted alkyl), —SO 2 —(C 1 to C 4 alkyl), —SO 2 —(C 1 to C 4 substituted alkyl), —CO—(C 1 to C 4 alkyl), —CO—(C 1 to C 4 substituted alkyl), C 1 to C 4 alkyl, C 1 to C 4 substituted alkyl, —O—(CH 2 ) n -aryl, —COO—(C 1 to C 4 alkyl), —COO—(C 1 to C 4 substituted alkyl), —CONH—(C 1 to C 3 alkyl), —CON—(C 1 to C 3 alkyl) 2 ,aryl, substituted aryl, heteroaryl or substituted heteroaryl; n is 0 to 3; p is 1 to 3; or a pharmaceutically acceptable salt or tautomer thereof.