Patent ID: 8524705

Claim:
A tetrahydroindolizine derivative of formula (I), or a pharmaceutically or agriculturally acceptable salt thereof: wherein: R1 represents hydrogen, unsubstituted or substituted C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —COR′ or —SO 2 (C1-C4 alkyl), or a group -A2, -L2-A2, -L3-A2 or -A2-L3-A3; A1, A2 and A3 are the same or different and represent C3-C6 cycloalkyl or an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group; L1 represents a bond, a C1-C6 alkylene group in which none, one, two or three —CH 2 — groups are independently replaced by —O—, —S— or —NR′—, or a 5- to 12-membered heterocyclyl group; L2 represents —NR′—, —O—, —CO—, —OCO—, —OCONR′R″—, —CONR′R″— or —SO 2 —; L3 represents a bond or a C1-C4 alkylene group in which none, one or two —CH 2 — groups are independently replaced by —O—, —S— or —NR′—; n represents 0 or 1; R8 represents hydrogen or C1-C4 alkyl; R2 represents an unsubstituted or substituted group selected from C6-C10 aryl, a 5- to 12-membered heterocyclyl group, C1-C8 alkyl and C3-C6 cycloalkyl, halogen or a group of formula —B1—B2; B1 represents an unsubstituted or substituted C6-C10 aryl group; B2 represents an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group; R3, R4, R5 and R6 independently represent C6-C10 aryl, a 5- to 12-membered heterocyclyl group, —(C1-C4 alkylene)-(C6-C10 aryl), —(C1-C4 alkylene)-(5- to 12-membered heterocyclyl), hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, halogen, C3-C6 cycloalkyl, —OR′, —SR′, —SOR′, —SO 2 R′, —SO 2 NR′R″, —SO 3 H, —NR′R″, —NR′COR′, —CO 2 R′, —CONR′R″, —COR′, —OCOR′, —CF 3 , —NSO 2 R′ or —OCONR′R″; R7 represents hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —OR′, —CO 2 R′, —CONR′R″, —COR′, —CN, —NO 2 , —NR′R″, CF 3 , —Y—Z, C6-C10 aryl or a group of formula -Alk 6 -L5-A12, where Alk 6 is a C1-C4 alkylene group, L5 is a group of formula —O—C(═O)—, —C(═O)— or —NR13-C(═O)— and R13 is hydrogen or C1-C4 alkyl, and A12 is an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group; Y represents C1-C8 alkylene, C2-C8 alkenylene or C2-C8 alkynylene; Z represents halogen, C3-C6 cycloalkyl, —OR′, —SR′, —SOR′, —SO 2 R′, —SO 2 NR′R″, —SO 3 H, —NR′R″, —NR′COR′, —NO 2 , —CO 2 R′, —CONR′R″, —COR′, —OCOR′, —CN, —CF 3 , —NSO 2 R′, —OCONR′R″ or —CR′═NOR″; and R′ and R″ independently represent hydrogen, C1-C8 alkyl, C2-C8 alkenyl or C2-C8 alkynyl.