Patent ID: 6887880

Claim:
A compound of the formula (I): wherein: A is a member selected from the group consisting of: benzene, thiophene, furan, pyrrole, indole, wherein each B is independently selected from the group consisting of â€”C(â€”R 1 )(â€”R 2 )â€”, â€”Oâ€” and â€”N(â€”Jâ€”R 3 )â€”, wherein not more than one B in any ring is either â€”Oâ€” or â€”N(â€”Jâ€”R 3 )â€”; each m is independently an integer from 0 to 4; each n is independently an integer from 1 to 4; each q is independently an integer from 0 to 8; Y is a member selected from the group consisting of â€”(CH 2 ) q â€”, â€”(CH 2 ) m Oâ€” and â€”(CH 2 ) m â€”N(â€”J 1 â€”)â€”R 4 ; Z is a member selected from the group consisting of â€”(CH 2 ) n â€”C(â•O)â€”NHOH, â€”(CH 2 ) n COOH, â€”(CH 2 ) n COOMe and â€”(CH 2 ) n COOEt; L is a member selected from the group consisting of â€”(CH 2 ) q â€”, â€”(CH 2 ) m Oâ€” and â€”(CH 2 ) m â€”Nâ€”(â€”J 2 â€”)â€”R 5 ; J, J 1 and J 2 are each independently selected from the group consisting of C(â•O) and a bond; R 1 is a member selected from the group consisting of H, â€”N(â€”J 3 â€”R 6 )(â€”J 4 â€”R 7 ) and â€”Oâ€”J 5 â€”R 8 , wherein J 3 , J 4 and J 5 are each independently selected from the group consisting of â€”C(â•O)â€” and a bond, wherein at least one of J 3 and J 4 is a bond; R 2 is a member selected from the group consisting of H, â€”N(â€”J 6 â€”R 9 )(â€”J 7 â€”R 10 ) and â€”Oâ€”J 8 â€”R 11 , wherein J 6 , J 7 and J 8 are independently selected from the group consisting of â€”C(â•O)â€” and a bond, wherein at least one of J 6 and J 7 is a bond; R 3 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 12 ; R 4 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 13 ; R 5 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 14 ; R 6 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 15 ; R 7 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 16 ; R 8 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 17 ; R 9 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 18 ; R 10 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 19 ; R 11 is a member selected from the group consisting of H, C 1 -C 8 alkyl, CF 3 and Oâ€”R 20 ; R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 and R 20 are each independently selected from the group consisting of C 1 -C 4 alkyl, cycloalkyl and benzyl; and all pharmaceutically acceptable stereoisomers, and prodrugs thereof.