Patent ID: 7317019

Claim:
A compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: Z is selected from a —NR 15 —, —NR 15 —CR 24 R 24 —, —CHR 24 —NR 15 —; R 1 is selected from H, C 1-6 alkyl substituted with 0-3 R 4 , C 2-6 alkenyl substituted with 0-3 R 4 , C 2-6 alkynyl substituted with 0-3 R 4 , R 2 is quinazolinyl substituted with 0-3 R 5 ; R 3 is selected from (CRR) q OH; R 3e , at each occurrence, is selected from C 1-6 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, Cl, F, Br, or I; R, at each occurrence, is independently selected from H, C 1-6 alkyl substituted with 0-3 R 3e , C 2-8 alkenyl substituted with 0-3 R 3e , C 2-8 alkynyl substituted with 0-3 R 3e ; R 4 , at each occurrence, is selected from C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, and (CH 2 ) r C 3-6 cycloalkyl substituted with 0-3 R 4e , Cl, Br, I, F; R 4e , at each occurrence, is selected from C 1-6 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, (CH 2 ) r C 3-6 cycloalkyl, Cl, F, Br, I, CN, NO 2 , (CF 2 ) r CF 3 , (CH 2 ) r OC 1-5 alkyl, OH, SH, (CH 2 ) r SC 1-5 alkyl, and (CH 2 ) r NR 4f R 4f ; R 4f , at each occurrence, is selected from H, C 1-5 alkyl, and C 3-6 cycloalkyl; R 5 , at each occurrence, is selected from C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, (CH 2 ) r C 3-6 cycloalkyl, Cl, Br, I, F, C 1-6 haloalkyl, C 2-8 alkenyl substituted with 0-3 R′, and C 2-8 alkynyl substituted with 0-3 R′; R′, at each occurrence, is selected from H, C 1-6 alkyl, C 2-8 alkenyl, and C 2-8 alkynyl; R 6 , is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 7 , is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 8 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 9 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 10 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 11 , is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 12 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 14 and R 14a are independently selected from H, and C 1-4 alkyl substituted with 0-1 R 14b ; R 14b , at each occurrence, is independently selected from —OH, —SH, —NR 14c R 14c , —C(O)NR 14c R 14c , —NHC(O)R 14c and phenyl; R 14c is selected from H, C 1-4 alkyl and C 3-6 cycloalkyl; R 15 is selected from H, C 1-4 alkyl, and C 3-6 cycloalkyl; R 17 is selected from H, C 1-4 alkyl, and C 3-4 cycloalkyl; R 24 , at each occurrence, is independently selected from H and C 1-4 alkyl; n is selected from 1 and 2; 1 is selected from 0 and 1; m is selected from 0 and 1; q, at each occurrence, is selected from 1, 2, 3, or 4; and r, at each occurrence, is selected from 0, 1, 2, 3, or 4.