Patent ID: 8906911

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 is formula (a) or (b): A is CH 2 or CH 2 CH 2 ; Z 1 and Z 2 , are each independently —C(O)O(alkyl), aryl, or monocyclic heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, halogen, C 1 -C 6 haloalkyl, CN, OR a , NR b R c , —C(O)NR b R c , and —S(O) 2 NR b R c ; wherein R a , R b , and R c , at each occurrence, are each independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl; R 2 is hydrogen or C 1 -C 6 alkyl wherein the C 1 -C 6 alkyl is optionally substituted with C 1 -C 6 haloalkyl, alkoxy, or haloalkoxy, and R 3 is: wherein R 4 is C 1 -C 6 alkyl, O(C 1 -C 6 alkyl), or O(C 1 -C 6 haloalkyl); R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 11 , are each independently hydrogen, C 1 -C 6 alkyl, or halogen; or R 2 and R 3 , together with the nitrogen atom to which they are attached, form a ring of formula (i), (ii), or (iii): wherein: R 12 , at each occurrence, represents an optional substituent on any substitutable carbon atom, and is independently C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, CN, OH, or halogen; n is 0, 1, or 2; p is 1 or 2; q is 1 or 2; G 1 is aryl which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C 1 -C 6 alkyl, halogen, C 1 -C 6 haloalkyl, OH, alkoxy, haloalkoxy, CN, —C(O)OH, —C(O)O(alkyl), —(C 1 -C 6 alkylenyl)-OH, —(C 1 -C 6 alkylenyl)-C(O)OH, or tetrazolyl; R 13 is hydrogen, C 1 -C 6 alkyl, or —(C 1 -C 6 alkylenyl)-O(alkyl); R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , and R 20 , are each independently hydrogen or C 1 -C 6 alkyl; X is CH 2 , O, N(R w ) wherein R w is hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl; r is 1 or 2; s is 0, 1, 2, 3, or 4; and R 21 , at each occurrence, represents an optional substituent on any substitutable carbon atom of the bicyclic ring, and is independently halogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl.