Patent ID: 7838029

Claim:
A method for preparing a non-effervescent, orally disintegrating mirtazapine tablet consisting of: a) preparing a dry mixture consisting of: i) about 0.5% to about 10% of mirtazipine; ii) about 35% to about 65% by weight of mannitol; iii) about 15% to about 35% by weight of crosspovidone; iv) about 5 to about 15% of microcrystalline cellulose; v) about 0.5% to about 4% at least one lubricant; vi) 0 to about 10% of a salivating agent; vii) colloidal silicon dioxide; viii) optionally a coloring agent; xi) optionally a flavoring agent; and x) optionally a sweetner; b) compressing the dry mixture into 15 mg, 30 mg or 45 mg mirtazipine tablets with a hardness of about 1.5 kp to about 3 kp and a tablet hardness greater than 1.0 kp after exposure for 24 hours at 25° C. and 60% relative humidity and greater than about 0.8 kp after exposure for 60 minutes at 40° C. and 75% relative humidity.