Patent ID: 8486908

Claim:
An antagonist of TLR7 and/or TLR9 having the structure 5-N p N 3 N 2 N 1 C*G1N 1 N 2 N 3 N z N 4 N 5 -3′, wherein C*G* is an oligonucleotide motif wherein C* is 5-Me-dC, and G1 is 7-deaza-dG; N 1 -N 2 , at each occurrence, is independently a 2′-O-Me-ribonucleotide; N 3 , at each occurrence, is independently a nucleotide; N 1 -N 3 , at each occurrence, is independently a nucleotide; N m and N m , at each occurrence, is independently a nucleotide; N 4 -N 5 , at each occurrence, is independently a 2′-O-Me-ribonucleotide; p is 5; and z is 3; provided that the compound contains less than 3 consecutive guanosines.