Patent ID: 6939561

Claim:
A method for reducing the toxicity of a therapeutic agent which is polyene antibiotic, an acylated prodrug, an acylated cis-platin, paclitaxel or tamoxifen., said method comprising the steps of: (a) dissolving a therapeutic agent which is a polyene antibiotic, paclitaxel, tamoxifen, acylated prodrug, or an acylated cis-platin and polyethylene oxide-block-poly-N-(alkyl-fatty acyl) L-aspartamide (polymer) in a solvent, said polymer having a number of L-aspartate monomer residues from 10 to 30, said alkyl having from 2 to 8 carbon atoms and said fatty acyl having from 8 to 28 carbon atoms, in a solvent to produce a solution; (b) evaporating the solvent from the solution of step (a) under conditions selected from the group consisting of 40° C. and 300 mm mercury, 33° C. and 200 mm mercury and 26° C. and 100 mm mercury to produce a therapeutic agent-polymer film; (c) adding water to the therapeutic agent-polymer film of step (b) and mixing vigorously, whereby micelles comprising a therapeutic agent and polymer are formed.