Patent ID: 8883793

Claim:
A compound for inhibition of tubulin polymerization having a structure shown in formula (Ib) or a pharmaceutically acceptable salt thereof, wherein A is Ch 2 , O, S, or NH; Q is thiazole; Y is CH 2 —CH 2 ; R 1 and R 2 are each independently selected from the group consisting of aryl, and heteroaryl, provided that the heteroaryl does not include furan or thiophene, wherein said aryl and heteroaryl are each optionally substituted with one or more substituents selected from R f and R g , wherein R f and R g are each independently selected from the group consisting of: hydrogen, halogen, (C 1-4 )alkyl, (C 1-4 )alkoxyl, O—(C 1-4 )alkyl, S—(C 1-4 ) alkyl, aryl, heteroaryl, N(R c )(R d ), COR c , CON(R c )(R d ), NR c- CO—N(R c )(R d ), O—CO—N(R c )(R d ), NR c —S(O) n —N(R c )(R d ), or R f and R g can join together with carbon, nitrogen or sulfur atoms to which they are attached to form a ring selected from the group consisting of a cycloalkyl and a heterocycloalkyl, R c and R d are each independently selected from the group consisting of hydrogen, halogen, (C 1-6 )alkyl, (C 1-6 )alkoxyl, (C 6-19 )aryl, heteroaryl, (C 3-12 )cycloalkyl, or R c and R d can join together with carbon, nitrogen or sulfur atoms, to which they are attached, to form a 5-7 membered ring; and n is 0, 1, or 2.