Patent ID: 8648146

Claim:
A method for preparing a separation matrix, said method comprising reacting together: a) a matrix having the formula: M-A-H wherein: M is a solid support; A is an atom or group selected from —O—, —S—and —NR 1 —, where R 1 is selected from H and C 1 -C 4 alkyl; and b) a compound of formula: X—(CH 2 ) r —P, wherein: X is the group: wherein R 2 is H; where R 3 is selected from H and C 1 -C 4 alkyl; P is the group: where L is a linking group and is a branched or unbranched chain of covalently linked atoms having from 1-20 linear atoms selected from the group consisting of carbon, oxygen and sulphur atoms; and r is 0 or 1; wherein said method is performed in the presence of a phase transfer catalyst.