Patent ID: 7666852

Claim:
A method for effective treatment of a wound or a cutaneous injury in a subject in need of such treatment via delivery of a glycosaminoglycan-decorated proteoglycan polypeptide, the method comprising administering via local delivery to a target cell at a site of the wound or cutaneous injury in the subject a composition comprising a vector and a nucleic acid encoding a proteoglycan polypeptide, said nucleic acid comprising a first nucleic acid sequence encoding a sequence sufficient for secretion and a second nucleic acid sequence encoding a polypeptide having one or more sites for the attachment of a glycosaminoglycan chain, whereby a glycosaminoglycan-decorated polypeptide is generated in the target cell by the subject and subsequently secreted from the target cell to deliver an effective amount of glycosaminoglycan to the wound or the cutaneous injury resulting in an improvement in effective treatment of the wounds or the cutaneous injury in the subject, said nucleic acid being delivered in therapeutically effective amount.