Patent ID: 6872716

Claim:
A compound represented by B: wherein Z represents N or CR; m is 0, 1, 2, 3 or 4; p is 1, 2, or 3; y is 0, 1 or 2; R represents H, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; R 1 represents NR 2 , alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; R and R 1 may be connected through a covalent bond; R 2 represents independently for each occurrence H, alkyl, fluoroalkyl, aryl, heteroaryl, or cycloalkyl; R 3 represents independently for each occurrence H, alkyl, aryl, OR 2 , OC(O)R 2 , CH 2 OR 2 , or CO 2 R 2 ; R 4 represents H, alkyl, aryl, heteroaryl, alkenyl, or cycloalkyl; R 5 and R 6 are selected independently for each occurrence from the group consisting of H, alkyl, (CH 2 ) p Y, aryl, heteroaryl, F, OR 2 , and OC(O)R 2 ; or an instance of CR 5 R 6 taken together is C(O); R 8 and R 9 are selected independently for each occurrence from the group consisting of H, alkyl, (CH 2 ) p Y, aryl, heteroaryl, F, OR 2 , and OC(O)R 2 ; or an instance of CR 9 R 9 taken together is C(O); Y represents independently for each occurrence OR 2 , N(R 2 ) 2 , SR 2 , S(O)R 2 , S(O) 2 R 2 , or P(O)(OR 2 ) 2 ; any two instances of R 2 may be connected through a covalent bond; a covalent bond may connect R 4 and an instance of R 5 or R 6 ; any two instances of R 5 and R 6 may be connected through a covalent bond; any two geminal or vicinal instances of R 8 and R 9 may be connected through a covalent bond; and the stereochemical configuration at any stereocenter of a compound represented by B is R, S, or a mixture of these configurations.