Patent ID: 7541454

Claim:
A compound having a formula selected from the group consisting of: wherein Y 4 is C, S, or SO; each X 1 , X 2 , X 3 and X 4 is a member independently selected from the group consisting of H, halogen, cyano, halo(C 1 -C 8 )alkyl, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )alkylthio, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, SO 3 H and CO 2 H, or any two adjacent X 1 , X 2 , X 3 , and X 4 are combined to form a fused aromatic or heteroaromatic ring that is optionally further substituted with from one to four substituents selected from the group consisting of halogen cyano, carboxy, sulfo, hydroxy, amino, mono(C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio and (C 1 -C 6 )alkoxy; the moiety is a member selected from the group consisting of: optionally substituted with a member independently selected from the group consisting of halogen, cyano, halo(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )alkylthio, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, heteroaryl, SO 2 H and CO 2 H; each R 1 , R 2 , R 13 , R 14 or R 15 is a member independently selected from the group consisting of H, halogen, cyano, halo(C 1 -C 8 )alkyl, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkylthio, (C 1 -C 8 )alkoxy, aryl and heteroaryl, or R 14 and R 15 are combined with the atoms which attach them to form a 5- or 6-membered aromatic ring; each R 5 or R 6 is a member independently selected from the group consisting of H, (C 1 -C 8 )alkyl, aryl, heteroaryl, aryl(C 1 -C 4 )alkyl and heteroaryl(C 1 -C 4 )alkyl; R 7 is H or a hydroxyl protecting group; R 8 is NR 9 W(Y 2 P L), hydroxy, or a leaving group that can be displaced by a nucleophilic reagent; W is a linking group selected from the group consisting of a (C 2 -C 50 )alkylene, heteroalkylene, (C 2 -C 50 )cycloalkylene, heterocycloalkylene, (C 6 -C 50 )arylene group, a heteroarylene group, (C 2 -C 50 )alkylenearylene group, a heteroalkylenearylene group, optionally substituted with at least one substituent independently selected from the group consisting of(C 1 -C 8 )alkyl, hydroxy, protected hydroxy, alkoxy, amino, protected amino, hydrazino, thio, protected thio and aryl; R 9 is H, alkyl or combined with W to form a heterocycloalkylene, heterocycloalkylenearylene, or heterocycloalkyleneheteroarylene linking group; Y 2 is a linking group selected from the group consisting of: wherein dashed line indicates the point of attachment to L and the wavy line indicates the point of attachment to the rest of the molecule; each R 10 is independently (C 1 -C 8 )alkyl or (C 1 -C 8 )alkoxy; the subscript p is an integer of from 0 to 1; L is solid support when p is 1 and L is a member selected from the group consisting of an O-phosphoramidite or a reactive functional group when p is 0; and the subscript n is an integer of from 4 to about 20.