Patent ID: 8362204

Claim:
A method for synthesizing an organic compound with two or more dicarba bridges, the method comprising: (a) providing one or more reactable organic compounds having, within a single compound or between the one or more compounds (i) a first pair of complementary metathesisable olefin groups that are unblocked, (ii) a second pair of complementary metathesisable olefin groups that are blocked but can be unblocked by an unblocking reaction or series of reactions specific to the second pair, and (iii) optionally, one or more further pairs of complementary methathesisable olefin groups that are blocked but can be unblocked by an unblocking reaction or series of reactions specific to each further pair; (b) subjecting the reactable organic compound or compounds to olefin cross-metathesis to form an organic compound with an unsaturated dicarba bridge across the first pair of complementary metathesisable olefin groups, without olefin cross-metathesis between the pair or pairs of blocked complementary metathesisable olefin groups; (c) subjecting the second pair of complementary metathesisable olefin groups to the unblocking reaction or series of reactions specific to the second pair; (d) subjecting the second pair of complementary metathesisable olefin groups to olefin cross-metathesis to form an organic compound with an unsaturated dicarba bridge across the second pair of complementary metathesisable olefin groups, without olefin cross-methathesis between any pair or pairs of complementary methathesisable olefin groups that remain blocked; and (e) if any complementary metathesisable olefin groups remain, subjecting those groups to unblocking reactions specific to those pairs, followed by olefin cross metathesis.