Patent ID: 8299123

Claim:
A compound of formula (I): wherein: W, X, and Z are C; Y is O, NH, or S; n is 1; R 1 is (a) H; (b) C 1-8 alkyl, branched or unbranched, optionally partially or fully halogenated, and optionally substituted with one to two groups selected from —OH, CN, C 1-6 alkoxy, —CO 2 C 1-6 alkyl, and —CON(C 1-3 alkyl)(C 1-3 alkyl), (c) —(CH 2 ) 0-1 C 3-8 cycloalkyl, (d) —CH 2 Ar, wherein Ar is phenyl or heteroaryl selected from pyridinyl, triazolyl, pyrimidinyl, furanyl, thiazolyl, thienyl, pyrrolyl, imidazolyl, and benzofuranyl, each optionally substituted with one to two groups selected from halogen, —CN, —OH, C 1-6 alkyl, C 1-6 alkoxy, —CF 3 , —CO 2 C 1-6 alkyl, and —CONH 2 , or (e) —(CH 2 ) 2 OCH 2 Ar, wherein Ar is phenyl or heteroaryl selected from pyridinyl, triazolyl, pyrimidinyl, furanyl, thiazolyl, thienyl, pyrrolyl, imidazolyl, and benzofuranyl, each optionally substituted with one to two groups selected from halogen, —CN, —OH, C 1-6 alkyl, C 1-6 alkoxy, —CO 2 C 1-6 alkyl, —C(O)NH 2 ; or if X is C, and Y is O, R 1 may form a fused dihydropyran ring with the O it is bound to and X, said dihydropyran ring optionally substituted with one or two methyl groups; R 2 is (a) H, C 1-6 alkyl, C 1-6 alkoxy, hydroxyC 1-6 alkyl, halogen, —CN, —CO 2 C 1-6 alkyl, —S(O) 0-2 C 1-6 alkyl, —NO 2 , —OH, —CF 3 , —NH 2 , —NH(C 1-6 alkyl), —N(C 1-6 alkyl)(C 1-6 alkyl), —NHC(O)NHC 1-6 alkyl, —C(O)NH 2 , —CONH(C 1-6 alkyl), —CON(C 1-6 alkyl)(C 1-6 alkyl), or b) phenyl, pyridinyl, triazolyl, or pyrimidinyl, each optionally substituted with one or two groups selected from halogen, C 1-6 alkyl, —CN or C 1-6 alkoxy; R 3 is in the 4-position and is —CO 2 H, —(CH 2 ) 1-2 CO 2 H, —(CH 2 ) 0-1 C(CH 3 )(CH 3 )CO 2 H, —C(CH 3 )(CH 3 )CO 2 H, —O(CH 2 ) 1-4 CO 2 H, —O(CH 2 ) 0-1 C(C 1-6 alkyl)(C 1-6 alkyl)CO 2 H, —OC(C 1-6 alkyl)(C 1-6 alkyl)CO 2 H, —(CH 2 ) 0-1 tetrazol-5-yl, or —C(CH 3 )(CH 3 )tetrazol-5-yl; R 4 , R 5 , R 6 , and R 7 are independently selected from H and C 1-6 alkyl, or R 4 and R 6 may be joined, together with the carbons they are bonded to, to form a cyclopropane ring; R 8 , R 9 , R 10 , and R 11 are independently H, halogen, C 1-6 alkyl, C 1-6 alkoxy, —CN, —CO 2 C 1-6 alkyl, —C(O)NH 2 , —SO 2 NH 2 , —NO 2 , —OH, —NH 2 , —CF 3 , or —CH 2 OH; or a tautomer thereof or a salt thereof.