Patent ID: 7501539

Claim:
A process for the preparation of a compound of formula (I), in the form of any one of its isomers or a mixture thereof, wherein G represents a C═O or C(OR) 2 group, R representing, taken separately, a C 1 -C 5 alkyl group or, taken together, forming, together with the carbon and oxygen atoms of said G, a C 3 -C 7 1,3-dioxacycloalkane ring; a) R 1 represents a n-butyl group or a CH 2 X, CHO or CH 3-n Z n group, X standing for a halogen atom or a (3c-ethyl-bicyclo[2.2.1]hept-5-ene-2r-yl)methyl group; n being 1 or 2 and Z standing for a C(OR) 2 , OR 3 or SR 3 group; R′ representing a C 1 -C 5 alkyl group alone or, when Z is C(OR′) 2 or OR 3 , forming, together with the carbon and oxygen atoms of said Z, a C 3 -C 7 1,3-dioxacycloalkane ring; and R 3 representing, taken separately, a C 1-7 benzyl, alkyl, cycloalkyl or oxacycloalkyl group or a C 1-7 acyl, sulfonyl or silyl group, or, taken together, forming, together with the carbon and oxygen or sulfur atom to which they are bonded, a C 3 -C 7 1,3-dioxacycloalkane or 1,3-dithiacycloalkane ring; and b) R 2 represents a linear or branched C 1 to C 4 alkyl group; said process comprising: (1) reacting a compound of formula (II), with an orthoester or a malonate compound of formula CH 3 C(OR 2 ) 3 or CH 2 (COOR 4 ) 2 , respectively, and with an acid of a C 1-10 carboxylic acid, optionally halogenated, or a C 1-10 sulfonic acid to obtain a reaction mixture that includes an intermediate of formula (III) or (III′), respectively, wherein R 4 represents an R 2 group or a Si(R 5 ) 3 group and R 5 is a C 1 -C 4 alkyl group, and (2) heating the reaction mixture at a temperature range between 60° C. and 180° C. to thermally rearrange the intermediate of formula (III) or (III′) to obtain the compound of formula (1); and optionally, if the malonate compound is used in step (1), the thermal rearranging of the intermediate of formula (III′) is obtained by saponification, followed by decarboxylation and esterification with an alcohol of a formula R 2 OH.