Patent ID: 7754466

Claim:
A method for producing alanyl-glutamine, comprising: producing alanyl-glutamine by reacting an alanine ester and glutamine using a member selected from the group consisting of: a culture of a microbe, microbial cells separated from the culture, a treated microbial cell product, and a peptide-forming enzyme derived from the microbe; wherein: the microbe belongs to a genus selected from the group consisting of Achromobacter, Acinetobactor, Aeromonas, Agrobacterium, Alcaligenes, Arthrobacter, Beijerinckia, Brevibacterium, Clavibacter, Cryseobacterium, Escherichia, Enterobacter, Erwinia, Flavobacterium, Kluyvera, Microbacterium, Micrococcus, Mycoplana, Pantoea, Propionibacterium, Listonella, Rhizobium, Rhodococcus, Salmonella, Sarcina, Serratia, Stenotrophomonas, Staphylococcus, Streptomyces, Vibrio, Xanthomonas, Bullera, Candida, Cryptococcus, Filobacidium, Geotrichum, Pachysolen, Rhodosporidium, Rhodotorula, Sporoboromyces, Tremella, Torulaspora, Torulopsis, Acetobacter, Gluconobacter, Gluconacetobacter, Asaia, Zucharibacter, Actinomadura, Kitasatosporia, Micromonospora, Nocardia, Oerskovia, Saccharothrix, Saccharomyces , and Streptoverticillium; the microbe has an ability to produce alanyl-glutamine from the alanine ester and glutamine; the reaction of the alanine ester and glutamine proceeds by the following formula: R 1 —CH(NH 2 )—COOR +H 2 N—CH(COOH)R 2 →R 1 —CH(NH 2 )—CONH—CH(COOH)R 2 +ROH wherein R represents a substituted or unsubstituted hydrocarbon chain, R 1 represents a CH 3 , and R 2 represents (CH 2 ) 2 CONH 2 .