Patent ID: 7081454

Claim:
A compound according to formula I its enantiomers, diastereomers, pharmaceutically acceptable salts, hydrates, prodrugs and solvates thereof; wherein X is C; Y is O; W is N, R 3 is an optionally substituted morpholine, or homomorpholine; R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each independently selected from the group consisting of H, C 1-6 alkyl, alkenyl, alkynyl, cycloalkyl, halo, amino, —OR 60 , —NO 2 , —OH, —SR 60 , —NR 60 R 61 , —CN, —CO 2 R 60 , —CONR 60 R 61 , OCONR 60 R 61 , —NR 62 CONR 60 R 61 , —NR 60 SO 2 R 61 , —SO 2 NR 60 R 61 , —SO 2 R 63 , —C(NR 62 )NR 60 R 61 , aryl, —(CH 2 ) n OR 60 , —(CH 2 ) n NR 60 R 61 , —(CH 2 ) n SR 60 , —(CH 2 ) n aryl, —NH-Z-aryl, and; wherein n is 1 to 3; and Z is selected from the group consisting of C 1 –C 4 alkyl, alkenyl, and alkynyl chain; Z having one or more hydroxy, thiol, alkoxy, thioalkoxy, amino, halo, NR 60 SO 2 R 61 groups; Z optionally incorporating one or more groups selected from the group consisting of CO, CNOH, CNOR 60 , CNNR 60 , CNNCOR 60 and CNNSO 2 R 60; and R 60 , R 61 , R 62 , and R 63 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, hydroxy, alkoxy, aryl, and alkyl-R 25 ; R 25 is hydrogen, alkenyl, hydroxy, thiol, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, aryl, cyano, halo, sulfoxy, sulfonyl, —NR 30 COOR 31 , —NR 30 C(O)R 31 , —NR 30 SO 2 R 31 , —C(O)NR 30 R 31 ; and R 30 and R 31 are, independently, hydrogen, alkyl, or cycloalkyl.