Patent ID: 8067559

Claim:
A composition comprising: a) a yeast vehicle; and b) a recombinant fusion protein expressed by the yeast vehicle, the fusion protein comprising the following amino acid sequences: i) an amino acid sequence comprising positions 57-65 of a wild-type Ras protein having an amino acid sequence of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11 or SEQ ID NO:13, except that, as compared to the wild-type Ras protein, the glutamine at position 61 is mutated; and ii) an amino acid sequence comprising positions 3-165 of a wild-type Ras protein having an amino acid sequence of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11 or SEQ ID NO:13, except that, as compared to the wild-type Ras protein, the glycine at position 12 is mutated, and the glutamine at position 61 is mutated; wherein the amino acid sequence of (i) is appended to the N-terminus of the amino acid sequence of (ii).