Patent ID: 7091237

Claim:
A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein X 1 is O, S, NH or NCH 3 , C 1-3 alkyl, R 1 and R 2 are independently H or C 1-3 alkyl, R 3 , R 4 and R 5 are independently H, CH 3 , OCH 3 , CF 3 or halogen; R 26 and R 27 are independently H, C 1-3 alkyl or an R 26 and R 27 may, together with the carbon atom to which they are bonded form a 3–5 membered cycloalkyl ring; m is 0–3; X 2 is (CR 10 R 11 ) n , O, S, OCH 2 ; n=1 or 2; R 6 , R 7 , R 10 and R 11 independently represent H, F, C 1-6 alkyl, phenyl or allyl or form a double bond as indicated by the depicted dashed line; one of Y and Z is CH, the other is S or O with the proviso that Y cannot be substituted and Z can only be substituted when it is carbon, R 8 is phenyl or pyridyl (wherein the N is in position 2 or 3) either of which may optionally be substituted by one or more halogen, CF 3 , OCF 3 , C 1-6 straight or branched alkyl with the provision that when R 3 is pyridyl, the N is unsubstituted, R 9 is C 1-4 alkyl, CF 3 or —CH 2 D, wherein D is selected from: wherein R 12 is selected from the group consisting of moieties depicted below, R 17 and R 18 are independently hydrogen C 1-6 alkyl, C 1-6 perfluoroalkyl, C 1-6 acyl, —OC 1-6 alkyl, perfluoroOC 1-6 alkyl, or 1-hydroxyC 1-6 alkyl; R 19 is C 1-6 alkyl; R 22 is C 1-6 alkyl, 6-memberedaryl, 5-membered heteroaryl, —C 1-6 alkylenearyl; R 23 is C 1-6 alkyl, C 1-6 cycloalkyl, 6-membered aryl or a 5-membered heteroaryl optionally substituted with one or two substituents selected from perfluroC 1-6 alkyl, perfluroOC 1-6 alkyl, C 1-6 alkyl, —OC 1-6 alkyl and —SC 1-6 alkyl; and, R 24 is C 1-6 alkyl, —C 1-6 alkylenearylC 1-6 alkylaryl, or a 6-membered aryl optionally substituted with one or two substituents selected from perfluroC 1-6 alkyl, perfluroOC 1-6 alkyl, C 1-6 alkyl, —OC 1-6 alkyl, and —SC 1-6 alkyl; where Z is O, N or S (note that when Z is N, the depicted bond can be attached to the nitrogen in the ring as well as any of the carbons in the ring); R 20 is C 1-6 alkyl, 6 membered aryl, —OC 1-6 alkyl, hydroxy or 1-alkoxy C 1-6 alkyl, where R 13 and R 14 are independently halogen, a 6-membered aryl or a 5-membered heteroaryl optionally substituted with one or two substituents selected from perfluroC 1-6 alkyl, perfluroOC 1-6 alkyl, C 1-6 alkyl, —OC 1-6 alkyl, and —SC 1-6 alkyl; R 21 is C 1-3 -alkyl, —C 1-6 alkylenephenyl, 6-membered aryl, optionally substituted with one or two substituents selected from CN, 5 or 6-membered heteroaryl, bicyclic aryl or bicyclic heteroaryl, perfluroC 1-6 alkyl, perfluroOC 1-6 alkyl, C 1-6 alkyl, —OC 1-6 alkyl and —SC 1-6 alkyl, R 15 and R 16 are independently C 1-6 alkyl, C 3-6 cycloalkyl, C 0-6 alkylene 6-membered aryl optionally substituted with 1 or 2 C 1-3 alkyl or alkoxy groups, C 0-6 alkylene 5-membered heteroaryl, pyridyl, bicyclic aryl or bicyclic heteroaryl or R 12 as defined above, wherein n is 1 or 3, R 28 is 6 membered aryl, 5 or 6 membered heteroaryl or bicyclic aryl or bicyclic heteroaryl. wherein R 21 is defined above.