Patent ID: 8318706

Claim:
A compound of formula I: wherein X is CR 6′ R 6 , or C═CR 6′ R 6 ; E is NR 7d R 7e or OR 7f ; R 2 , R 2′ , R 4′ , R 4a and R 4b are each independently hydrogen, or alkyl; R 3 , R 10 , R 11 and R 12 are each hydrogen; R 4 is NR 4a R 4b ; R 5 and R 5′ are each independently hydroxyl, hydrogen or alkyl; R 6 and R 6′ are each independently hydrogen, hydroxyl, or alkyl; R 7a , R 7b , R 7c , R 7d , R 7e and R 7f are each independently hydrogen, alkyl, alkenyl, aryl, or arylalkyl, or R 7c and R 7d or R 7e and R 7f are linked to form a ring; R 8 is hydrogen; and R 9 is hydrogen, alkyl, alkenyl, alkynyl, aryl, alkoxy, amino, or aminoalkyl, or a pharmaceutically acceptable salt thereof.