Patent ID: 8513230

Claim:
A compound of formula III′: or a pharmaceutically acceptable salt thereof, wherein: A′ is phenyl substituted with one or more R 1″ ; each R 1′ is independently selected from the group consisting of halogen, —NO 2 , —CN, —OR a , —SR a , —N(R a ) 2 , —N 3 , or -L 1 -R; each R a is independently —H, —R or —C(O)R; L 1 is a covalent bond or an optionally substituted bivalent C 1-6 hydrocarbon chain, wherein one or more methylene units of L 1 is optionally and independently replaced by —Cy—, —O—, —S—, —N(R a )—, —C(O)—, —C(S)—, —C(O)N(R a )—, —N(R a )C(O)N(R a )—, —N(R a )C(O)—, —N(R a )C(O)O—, —OC(O)N(R a )—, —S(O)—, —S(O) 2 —, —S(O) 2 N(R a )—, —N(R a )S(O) 2 —, —OC(O)—, or —C(O)O—; —Cy— is an optionally substituted bivalent ring selected from a 3-7 membered saturated or partially unsaturated cycloalkylene ring, a 4-7 membered saturated or partially unsaturated heterocycloalkylene ring having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur, phenylene, a 5-6 membered monocyclic heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur, an 8-10 membered bicyclic arylene, or an 8-10 membered bicyclic heteroarylene having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; each R is independently optionally substituted C 1-8 alkyl; C 2-8 alkenyl; C 2-8 alkynyl; haloalkyl; phenyl; a 3-7 membered saturated or partially unsaturated cycloalkyl ring; an 8-10 membered bicyclic saturated, partially unsaturated or aryl carbocyclic ring; a 4-7 membered saturated or partially unsaturated heterocycloalkyl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 5-6 membered monocyclic heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or: two R on the same nitrogen are taken together with their intervening atoms to form a 4-7 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur; and R 3′ is -L 1 -R, wherein L 1 is —CH 2 — and R is a 5-6 membered monocyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur.