Patent ID: 7888464

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein n is 1, 2, or 3; R 1 is selected from hydroxy and —NHSO 2 R 7 ; R 2 is selected from hydrogen, alkenyl, alkyl, cyanoalkyl, cycloalkyl, and haloalkyl; R 3 is selected from alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and heterocyclylalkyl; R 4 is —OR 8 ; R 5 is selected from alkenyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, arylalkyl, carboxyalkyl, cyanoalkyl, cycloalkyl, (cycloalkyl)alkyl, haloalkoxyalkyl, haloalkyl, hydroxyalkyl, (NR a R b )alkyl, and (NR a R b )carbonylalkyl; R 6 is selected from alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkyloxycarbonyl, cycloalkyl, haloalkoxycarbonyl, haloalkyl, haloalkylcarbonyl, (NR a R b )carbonyl, and (NR a R b )sulfonyl; or R 6 is selected from phenyl and a five- or six-membered partially or fully unsaturated ring optionally containing one, two, three, or four heteroatoms selected from nitrogen, oxygen, and sulfur; wherein each of the rings is optionally substituted with one, two, three, or four substitutents independently selected from alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfanyl, carboxy, cyano, cycloalkyl, cycloalkyloxy, halo, haloalkyl, haloalkoxy, —NR g R h , (NR j R k )carbonyl, (NR j R k )sulfonyl, and oxo; R 7 is selected from alkyl, aryl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and —NR c R d ; R 8 is selected from alkoxyalkyl, alkyl, alkylcarbonyl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkylcarbonyl, haloalkoxyalkyl, haloalkyl, (NR e R f )carbonyl, and —P(O)(OR′) 2 ; wherein R e and R f are independently selected from hydrogen, alkyl, and arylalkyl; or R e and R f , together with the nitrogen atom to which they are attached, form a five or six-membered monocyclic heterocyclic ring optionally containing one additional heteroatom selected from O, NR x , and S; wherein R x is selected from hydrogen and alkyl; and wherein R′ is selected from hydrogen and alkyl; R a and R b are independently selected from hydrogen, alkoxy, alkoxyalkyl, alkyl, aryl, arylalkyl, cycloalkyl, haloalkoxyalkyl, haloalkyl, heterocyclyl, and heterocyclylalkyl; R c and R d are independently selected from alkoxy, alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and heterocyclylalkyl; or R c and R d together with the nitrogen atom to which they are attached form a five or six-membered monocyclic heterocyclic ring; R g and R h are independently selected from hydrogen, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, arylalkyl, and haloalkyl; and R j and R k are independently selected from hydrogen, alkyl, aryl, arylalkyl, and heterocyclyl; wherein the aryl, the aryl part of the arylalkyl, and the heterocyclyl are optionally substituted with one or two substituents independently selected from alkoxy, alkyl, and halo.