Patent ID: 8268822

Claim:
A compound of formula I-A-i: or a pharmaceutically acceptable salt thereof, wherein: Cy t is phenyl optionally substituted by one to three independent occurrences of R 9 ; each occurrence of R 9 is independently selected from —OR B , —N(R B )C(O)R A , —N(R B ) 2 , halo, C 1-4 aliphatic optionally substituted by halo, NO 2 , —OS(O) 2 R C , —S(O)R C , —N(R B )SO 2 R A , or —S(O) 2 N(R B ) 2 ; each occurrence of R A is independently H, C 1-3 alkyl or C 3-5 cycloalkyl; each occurrence of R B is independently H or C 14 aliphatic; or two R B on the same nitrogen atom taken together with the nitrogen atom form a 5-8 membered aromatic or non-aromatic ring having in addition to the nitrogen atom 0-2 ring heteroatoms selected from N, O or S; and each occurrence of R C is independently C 1-4 aliphatic; ring A is optionally substituted with 1 or 2 independent occurrences of R 5 , wherein R 5 on ring A, when present, is selected from F, Cl, Br, or methyl; W is L 1 —R 7 , L 1 is an optionally substituted C 1-6 alkylene chain; R 7 is H, halo, —OH, —N(R F ) 2 , —CN, —OR G , —C(O)R G , —CO 2 H, —CO 2 R G , —SR G , —S(O)R G , —S(O) 2 R G , —N(R E )C(O)R G , —N(R E )CO 2 R G , —N(R E )SO 2 R G , —C(O)N(R F ) 2 , —SO 2 N(R F ) 2 ,—N(R E )C(O)N(R F ) 2 , —OC(O)R F or an optionally substituted group selected from C 1-10 aliphatic, C 6-10 aryl, 3-14 membered heterocyclyl or 5-14 membered heteroaryl, wherein each occurrence of R F is independently H, C 1-6 aliphatic, C 6-10 aryl, 3-14 membered heterocyclyl, 5-14 membered heteroaryl, —C(═O)R B , —C(O)OR B or —SO 2 R B ; or two R F on the same nitrogen atom taken together with the nitrogen atom form an optionally substituted 5-8 membered aromatic or non-aromatic ring having in addition to the nitrogen atom 0-2 ring heteroatoms selected from N, O or S; and each occurrence of R G is C 1-6 aliphatic, C 6-10 aryl, 3-14 membered heterocyclyl, or 5-14 membered heteroaryl.