Patent ID: 7566741

Claim:
A method of treating bone loss comprising the step of administering to said patient an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis and/or osteoclast function, wherein said TRANCE/RANK inhibitor is a compound selected from Formula I wherein: R 1 , and R 2 are, independently, selected from the group consisting of —H, —OCH 3 , —CH 2 CH 3 , -t-butyl, 3-carboxy-4-chlorophenylamino, —N—(CH 2 CH 2 OH) 2 , and —O(O)C-Ph; R 3 is selected from the group consisting of —H, ethyl, —OCH3, —Cl, Br, F, 3carboxy-4chlorophenylamino, —N—(CH 2 CH 2 OH) 2 , -t-butyl, and —OC(O)-Ph, and is not limited to attachment at any certain position on the phenyl ring to which it is attached; and R 4 is selected from the group consisting of —Br, —Cl, and —F.