Patent ID: 6958240

Claim:
A polyamide molecule that specifically binds to base pairs in the minor groove of a DNA molecule, said polyamide molecule comprising: one or more amino acids comprising a moiety selected from the group consisting of N-methylpyrrole, 3-hydroxy-N-methylpyrrole, and N-methylimidazole, wherein one or more of said amino acid(s) are not α-amino acids; and a positive patch consisting of a rigid group adjacent to a positively charged group, said rigid group comprising a first and a second amino acid; said first amino acid being selected from the group consisting of arginine, proline, lysine, and hydroxyproline; and said second amino acid being selected from the group consisting of proline, glycine, serine, threonine, leucine, isoleucine, valine, alanine, and hydroxyproline.