Patent ID: 8227411

Claim:
A fibroblast growth factor heparin-binding analog of formula I: wherein: X comprises a sequence selected from SEQ ID NO 7, SEQ ID NO 25 or SEQ ID NO 26; R 1 is either a single trifunctional amino acid residue covalently bonded to each X or is a dipeptide of the formula AA 1 -AA 2 wherein AA 1 -AA 2 are each a trifunctional amino acid; R 2 is 0; Each R 3 is hydrogen (H) such that the terminal group is NH 2 , or is an acyl group with a linear or branched C 1 to C 17 alkyl, aryl, heteroaryl, alkene, alkenyl or aralkyl chain including an N-terminus NH 2 , NH 3 + , or NH group or a corresponding acylated derivative; R 4 is present as NH 2 or H; R 5 is OH, NH 2 , or an acyl group with a linear or branched C 1 to C 17 alkyl, aryl, heteroaryl, alkene, alkenyl or aralkyl chain; Y is a linker comprising Ahx-Ahx-Ahx; and Z is selected from SEQ ID NO 2 or SEQ ID NO 5.