Patent ID: 7351691

Claim:
A compound of formula II: or a pharmaceutically-acceptable salt thereof; wherein R 3 , R 5 and R 20 are selected from: R 3 R 5 R 20 (a) phosphono- H CH 3 (CH 2 ) 9 NHCH 2 CH 2 — methylamino (b) phosphono- H CH 3 (CH 2 ) 9 OCH 2 CH 2 — methylamino (c) phosphono- H CH 3 (CH 2 ) 9 SCH 2 CH 2 — methylamino (d) phosphono- H CH 3 (CH 2 ) 12 — methylamino (e) phosphono- H 4-(4-chlorophenyl)benzyl methylamino (f) phosphono- H 2-(4-(4-chlorophenyl)- methylamino benzylamino)ethyl (g) phosphono- H 4-(4′-chlorobiphenyl)butyl methylamino (h) phosphono- H 5-(4′-chlorobiphenyl)pentyl methylamino (i) 3-phosphono- H CH 3 (CH 2 ) 9 SCH 2 CH 2 — propylamino (j) 2-hydroxy-2- H 4-(4-chlorophenyl)benzyl phosphono- ethylamino (k) OH (phosphonomethyl)- CH 3 (CH 2 ) 9 NHCH 2 CH 2 — aminomethyl (l) OH (phosphonomethyl)- CH 3 (CH 2 ) 9 SCH 2 CH 2 — aminomethyl (m) OH (phosphonomethyl)- CH 3 (CH 2 ) 9 OCH 2 CH 2 — aminomethyl (n) OH (phosphonomethyl)- CH 3 (CH 2 ) 12 — aminomethyl (o) OH (phosphonomethyl)- 4-(4-chlorophenyl)benzyl aminomethyl (p) OH (phosphonomethyl)- 2-(4-(4-chlorophenyl)- aminomethyl benzylamino)ethyl (q) OH (phosphonomethyl)- 4-(4′-chlorobiphenyl)butyl aminomethyl (r) OH (phosphonomethyl)- 5-(4′-chlorobiphenyl)pentyl aminomethyl (s) OH (phosphonomethyl)- 3-[4-(4-chlorobenzyloxy)- aminomethyl benzylthio]propyl (t) OH N-(2-hydroxy-2- CH 3 (CH 2 ) 9 SCH 2 CH 2 — phosphonoethyl)- aminomethyl (u) OH N-(carboxymethyl)- CH 3 (CH 2 ) 9 SCH 2 CH 2 — N-2-phosphono- methyl)aminomethyl (v) OH N,N-bis(phosphono- CH 3 (CH 2 ) 9 NHCH 2 CH 2 — methyl)aminomethyl (w) OH 3-phosphonopropyl- CH 3 (CH 2 ) 9 SCH 2 CH 2 — aminomethyl (x) OH 3-phosphonopropyl- 4-(4-chlorophenyl)benzyl aminomethyl (y) phosphono- —CH 2 —N—(N— CH 3 (CH 2 ) 9 NHCH 2 CH 2 —; methylamino CH 3 —D-glucamine and (z) OH (phosphonomethyl)- —(CH 2 ) 3 NH—SO 2 —4-(4- aminomethyl chlorophenyl)phenyl.