Patent ID: 7660677

Claim:
A computer-readable recording medium containing a program for designing a physiologically active peptide capable of interacting with a target protein, allowing a computer to execute: (a3) a step for exhaustively generating amino acid sequences of constant length, and randomly selecting amino acid sequences from among them for extraction as a library for analysis, (b3) a step for calculating an intermolecular energy parameter between each of the amino acid sequences extracted as a library for analysis and a target site of the target protein, (c3) a step for generating a score matrix based on amino acid prevalence using the intermolecular energy parameter calculated in step (b3), (d3) a step for calculating a score based on amino acid prevalence using the score matrix based on amino acid prevalence generated in step (c3), (e3) a step for conducting a correlation analysis between the intermolecular energy parameter calculated in step (b3) and said score to obtain a regression equation, (f3) a step for converting the score matrix based on amino acid prevalence generated in step (c3) to a matrix based on an amino acid position-dependent intermolecular energy parameter using said regression equation, (g3) a step for calculating an amino acid position-dependent intermolecular energy parameter value from the matrix based on an amino acid position-dependent intermolecular energy parameter converted in step (f3), (h3) a step for extracting amino acid not sequences higher than a specified amino acid position-dependent intermolecular energy parameter value, (i3) a step for calculating an intermolecular energy parameter with the target site of the target protein, for the amino acid sequences extracted in step (h3), (j3) a step for storing the amino acid sequences extracted in step (h3), along with the intermolecular energy parameter calculated in step (i3), in a storage, (k3) a step for extracting a specified number of amino acid sequences on the basis of information stored by step (j3), and (l3) a step for displaying the amino acid sequences extracted in step (k3) as candidates for a physiologically active peptide.