Patent ID: 8003378

Claim:
A bioreactor comprising: (i) a first substrate having a first surface, an opposite second surface and edges; (ii) a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, wherein the bottom surface is located therebetween the first surface of the second substrate and the second surface of the second substrate, and wherein the first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving biological cells and a liquid medium; (iii) a recess formed in the second substrate with a bottom surface and in fluid communication with the channel; and (iv) a barrier positioned for covering the recess so as to form an outer chamber, wherein the barrier has a porosity to allow the channel and the outer chamber to be in fluid communication and control the movement of at least one predetermined type of biological cells between the channel and the outer chamber, and wherein at least a portion of the barrier is arranged substantially perpendicular to the first surface of the first substrate.