Patent ID: 7122351

Claim:
A polynucleotide encoding a polypeptide fusion consisting of, from amino terminus to carboxyl terminus, the following operably linked segments: P1-P2-h-C H 2-C H 3; P1-P2-C H 2-C H 3; h-C H 2-C H 3-P2-P1; or C H 2-C H 3-P2-P1; wherein: P1 is a first polypeptide segment as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365 to 370, inclusive; P2 is a second polypeptide segment consisting of from 4 to 20 amino acid residues; h is an immunoglobulin hinge region or portion thereof; and C H 2 and C H 3 are C H 2 and C H 3 domains of an immunoglobulin heavy chain, respectively.