Patent ID: 7183292

Claim:
A compound of formula I: wherein each R 1 and R 2 is independently selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, cyano, halo, —OR a , —SR a , —S(O)R a , —S(O) 2 R a and —NR b R c ; or two adjacent R 1 groups or two adjacent R 2 groups are joined to form C 3-6 alkylene, —(C 2-4 alkylene)—O— or —O—(C 1-4 alkylene)—O—; each R 3 is independently selected from C 1-4 alkyl and fluoro; each R 4 is independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 6-10 aryl, C 2-9 heteroaryl, C 3-6 heterocyclic, —CH 2 —R 6 and —CH 2 CH 2 —R 7 ; or both R 4 groups are joined together with the nitrogen atom to which they are attached to form C 3-6 heterocyclic; R 5 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, and —CH 2 —R 8 ; wherein each alkyl, alkenyl and alkynyl group is optionally substituted with —OH or 1 to 5 fluoro substituent; each R 6 is independently selected from C 3-6 cycloalkyl, C 6-10 aryl, C 2-9 heteroaryl and C 3-6 heterocyclic; each R 7 is independently selected from C 3-6 cycloalkyl, C 6-10 aryl, C 2-9 heteroaryl, C 3-6 heterocyclic, —OH, —O(C 1-6 alkyl), —O(C 3-6 cycloalkyl), —O(C 6-10 aryl), —O(C 2-9 heteroaryl), —S(C 1-6 alkyl), —S(O)(C 1-6 alkyl), —S(O) 2 (C 1-6 alkyl), —S(C 3-6 cycloalkyl), —S(O)(C 3-6 cycloalkyl), —S(O) 2 (C 3-6 cycloalkyl), —S(C 6-10 aryl), —S(O)(C 6-10 aryl), —S(O) 2 (C 6-10 aryl), —S(C 2-9 heteroaryl), —S(O)(C 2-9 heteroaryl) and —S(O) 2 (C 2-9 heteroaryl); each R 8 is independently selected from C 3-6 cycloalkyl, C 6-10 aryl, C 2-9 heteroaryl and C 3-6 heterocyclic; each R a is independently selected from hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl and C 3-6 cycloalkyl; each R b and R c is independently selected from hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl and C 3-6 cycloalkyl; or R b and R c are joined together with the nitrogen atom to which they are attached to form C 3-6 heterocyclic; a is an integer from 0 to 3; b is an integer from 0 to 3; c is an integer from 0 to 4; d is 1 or 2; e is 8 or 9; wherein each alkyl, alkylene, alkenyl, alkynyl and cycloalkyl group in R 1 , R 2 , R 3 , R 4 , R 7 , R a , R b and R c is optionally substituted with 1 to 5 fluoro substituent; each aryl, cycloalkyl, heteroaryl and heterocyclic group in R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R a , R b and R c is optionally substituted with 1 to 3 substituents independently selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, cyano, halo, —O(C 1-4 alkyl), —S(C 1-4 alkyl), —S(O)(C 1-4 alkyl), —S(O) 2 (C 1-4 alkyl), —NH 2 , —NH(C 1-4 alkyl) and —N(C 1-4 alkyl) 2 , wherein each alkyl, alkylene, alkenyl and alkynyl group is optionally substituted with 1 to 5 fluoro substituent; and each —CH 2 — group in —(CH 2 ) e — is optionally substituted with 1 or 2 substituents independently selected from C 1-2 alkyl, —OH and fluoro; or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.