Patent ID: 8680061

Claim:
A method for producing a pharmaceutical composition comprising a combination of phospholipid and glycyrrhizic acid or a pharmaceutically acceptable salt thereof, which composition is hydratable to produce an injectable medicinal form, said method comprising subjecting a mixture of phospholipid and an aqueous solution of glycyrrhizic acid or a pharmaceutically acceptable salt thereof and a carbohydrate to homogenization under a pressure of from 800-1200 bar and at a temperature of between 20 and 50° C. where the mixture is subjected to from 5 to 22 homogenization cycles to form an emulsion comprising nanoparticles, and subjecting a product of the homogenization to a sublimation drying step to produce said composition having finely dispersed, homogenous and stable particles of a size of 20-100 nm, with 95% of said nanoparticles being of a size of 20-35 nm wherein the phospholipid used is from a vegetative extract having from 75-98% of phosphatidylcholine and the ratio of phospholipid to glycyrrhizic acid or pharmaceutically acceptable salt is not greater than 4:1.