Patent ID: 7662862

Claim:
A method of treating a 5-HT 7 mediated disease or condition selected from the group consisting of sleep disorder, shift worker syndrome, jet lag, depression, seasonal affective disorder, migraine, anxiety, psychosis, schizophrenia, pain, neuronal degeneration resulting from ischemic events, hypertension, irritable bowel syndrome, inflammatory bowel disease, spastic colon and urinary incontinence, said method comprising, administering a composition containing formula I: wherein W is a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl; R 1 , R 2 , R 3 , R 4 , R 4B , R 5 , R 5B , R 6 and R 7 are each independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR 8 , —C(O)OR 8 , —C(O)NR 8 R 9 , —HC═NR 8 , —CN, —OR 8 , —OC(O)R 8 , —S(O) t —R 8 , —NR 8 R 9 , —NR 8 C(O)R 9 , —NO 2 , —N═CR 8 R 9 or halogen; L is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR 8 , —C(O)OR 8 , —C(O)NR 8 R 9 , —HC═NR 8 , —CN, —OR 8 , —OC(O)R 8 , —S(O) t —R 8 , —NR 8 R 9 , —NR 8 C(O)R 9 , or —N═CR 8 R 9 ; and wherein the pair R 4 and R 4B or the pair R 5 and R 5B taken together may form a carbonyl group, t is 1, 2 or 3; R 8 and R 9 are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, halogen; n is 2, 3, 4 or 5; or a pharmaceutically acceptable salt, isomer, thereof and a pharmaceutically acceptable carrier, adjuvant or vehicle.