Patent ID: 7429584

Claim:
A compound of Formula I wherein Y is CH; Ar 1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C 1 -C 3 )alkoxy, halo, OH, CF 3 , CN, NO 2 and (C 1 -C 3 )alkyl, said alkyl being optionally substituted with CF 3 ; Ar 2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO 2 , CF 3 , (C 1 -C 6 )alkoxy, NR 1 R 1 , S(O) 2 R 2 , C(O)R 3 , and (C 1 -C 6 )alkyl optionally substituted with R 4 ; wherein at least one of Ar 1 and Ar 2 is not unsubstituted phenyl and wherein when Ar 1 or Ar 2 is substituted phenyl, said phenyl is not substituted with only 1 (C 1 -C 3 )alkyl substituent; R 1 is selected from H, S(O) 2 N[(C 1 -C 3 )alkyl] 2 , S(O) 2 NH(C 1 -C 3 )alkyl, C(O)(C 1 -C 3 )alkyl where said alkyl is optionally substituted with NR 5 R 5 , and (C 1 -C 3 )alkyl where said alkyl is optionally substituted with 1 or 2 substituents each selected independently from OH and (C 1 -C 3 )alkoxy, with the proviso that in any NR 1 R 1 group when one R 1 is S(O) 2 N[(C 1 -C 3 )alkyl] 2 , S(O) 2 NH(C 1 -C 3 )alkyl or C(O)(C 1 -C 3 )alkyl then the other R 1 must be other than S(O) 2 N[(C 1 -C 3 )alkyl] 2 , S(O) 2 NH(C 1 -C 3 )alkyl or C(O)(C 1 -C 3 )alkyl; R 2 is selected from (C 1 -C 3 )alkyl, pyrrolidinyl, and NH(C 1 -C 3 )alkyl where said alkyl is optionally substituted with OH; R 3 is selected from (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, morpholinyl, pyrrolidinyl, piperidinyl, and NH(C 1 -C 3 )alkyl where said alkyl is optionally substituted with OH, (C 1 -C 3 )alkoxy or N[(C 1 -C 3 )alkyl] 2 ; R 4 is selected from OH, CN, CF 3 , (C 1 -C 3 )alkoxy, C(O)NR 5 R 5 , NR 5 R 5 , and piperidinyl; and R 5 is selected from H, (C 1 -C 3 )alkyl, C(O)(C 1 -C 3 )alkyl, S(O) 2 (C 1 -C 3 )alkyl and piperidinyl, with the proviso that in any NR 5 R 5 group when one R 5 is C(O)(C 1 -C 3 )alkyl or S(O) 2 (C 1 -C 3 )alkyl, then the other R 5 must be other than C(O)(C 1 -C 3 )alkyl or S(O) 2 (C 1 -C 3 )alkyl; and excluding (3 -amino-6-phenylfuro[2,3 -b]pyridin-2-yl)(4-nitrophenyl)methanone, or a pharmaceutically acceptable salt thereof.