Patent ID: 8293916

Claim:
A compound of the formula Ia wherein R 1 is halogen or cyano; R 2 is lower alkyl; R 3 is phenyl, pyridinyl, or a diazine optionally substituted by one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, cycloalkyl, lower haloalkyl, lower haloalkoxy, cyano, NR′R″ or by 1-morpholinyl or by 1-pyrrolidinyl, optionally substituted by (CH 2 ) m OR, or by piperidinyl, optionally substituted by (CH 2 ) m OR, or by 1,1-dioxo-thiomorpholinyl or by piperazinyl, optionally substituted by lower alkyl or (CH 2 ) m -cycloalkyl; R is hydrogen, lower alkyl or (CH 2 ) m -cycloalkyl; R′ and R″ are each independently hydrogen, lower alkyl, (CH 2 ) m -cycloalkyl or (CH 2 ) n OR; m is 0 or 1; n is 1 or 2; and R 4 is CHF 2 , CF 3 , C(O)H, or CH 2 R 5 wherein R 5 is hydrogen, OH, C 1 -C 6 -alkyl or C 3 -C 12 -cycloalkyl; or a pharmaceutically acceptable salt thereof.