Patent ID: 8236283

Claim:
A method of imaging of wet age-related macular degeneration (AMD) of a human or animal body, using a contrast agent comprising a vector attached to an optical imaging reporter wherein the vector has affinity for receptors associated with angiogenesis; further wherein the contrast agent is defined by formula (Xa), A-Z (Xa) wherein A is defined by formula (Xb) R a —C(═O)—X 1 —X 2 —X 3 -G-D-X 4 —X 5 —X 6 —X 7 (Xb) and Z represents at least one optical imaging reporter selected from a fluorescein or a cyanine dye linked to one or more of X 1 , X 6 or X 7 of A, optionally via a spacer group; wherein A contains two cyclising bridge; X 3 , represents arginine or N-methylarginine; G represents glycine; D represents aspartic acid; R a represents a —(CH 2 ) n — or —(CH 2 ) n —C 6 H 4 — group, which forms part of a bridge to either X 2 , X 4 or X 6 , wherein n represents a positive integer from 1 to 10; X 1 represents a bond or 1, 2, 3, 4 or 5 amino acid residues, wherein at least one amino acid residue is optionally functionalised with a spacer moiety, or said amino acid residue possesses a functional side-chain selected from an acid or amine group which amino acid residue is selected from the group consisting aspartic or glutamic acid, lysine, homolysine, diaminoalcylic acid and diaminopropionic acid; X 2 and X 4 represent independently amino acid residues that forms a cyclising bridge; X 5 represents a hydrophobic amino acid; X 6 represents an amino acid residue that forms a cyclising bridge; and X 7 represents a biomodifier moiety comprising a monodispersed polyethylene glycol (PEG) building block comprising 1 to 10 units of said building block.