Patent ID: 7368532

Claim:
A composition comprising a therapeutic agent linked to a delivery polypeptide, SEQ ID NO. 12, wherein the delivery polypeptide is for delivery of a therapeutic agent to a neuronal cell, said delivery polypeptide comprising: a binding domain that binds to the neuronal cell and comprises a hybrid of a botulinum H C domian and a tetanus H C domain, and a translocation domain comprising an H N domain of a diphtheria toxin that translocates the therapeutic agent into the neuronal cell, wherein the delivery polypeptide has the binding specificity of tetanus toxin and reduced affinity to neutralizing antibodies to tetanus toxin compared with the affinity to such antibodies of native tetanus toxin heavy chain, and wherein the therapeutic agent is for reduction of neuronal damage after ischemia/reperfusion or is for promotion of neuronal growth after damage, and wherein the therapeutic agent is a polypeptide.