Patent ID: 8629119

Claim:
A method of reducing a cardiac stress response in a subject in need thereof comprising administering to the subject: an inhibitor of miR-208a or miR-208b, wherein the inhibitor of miR-208a or miR-208b is an antisense oligonucleotide comprising a sequence that is sufficiently complementary to a miR-208a or miR-208b sequence to hybridize to the miR-208a or miR-208b sequence under physiological conditions and inhibit the expression or activity of miR-208a or miR-208b in heart cells of said subject; and an inhibitor of miR-499, wherein the inhibitor of miR-499 is an antisense oligonucleotide comprising a sequence that is sufficiently complementary to a miR-499 sequence to hybridize to the miR-499 sequence under physiological conditions and inhibit the expression or activity of miR-499 in heart cells of said subject, and wherein the cardiac stress response is reduced in the subject within two weeks of administration of the inhibitors.