Patent ID: 7601691

Claim:
A compound comprising a peptide moiety and a Michael acceptor (MA) moiety, the MA moiety being capable of reacting with an amino group, a hydroxyl group or a thiol group on a blood protein so as to form a stable covalent bond, therewith, wherein the compound is of the formula: X 1 -X 2 Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln Arg X 3 (SEQ ID NO:22) wherein X 1 is ile, ile(N-MA) or ile(N-linking group-MA); X 2 is lys or lys(N ε -linking group-MA); X 3 is tyr or a tyr derivative of formula where R 1 is H, a protecting group (PG), a C 1 -C 10 branched, linear or cyclic alkyl, a phosphate or a sulfate; R 2 and R 3 are same or different and selected from the group consisting of H, D and I; and R 4 is OH, OPG, OR 5 , SH, SPG (sulfur protecting group), SR 5 , NH 2 , NHPG, N(PG) 2 , N(R 5 ) 2 ,NR 5 PG, or NHR 6 , where R 5 is a C 1 -C 10 branched, linear or cyclic alkyl, and R 6 is a solid phase support; and wherein X 1 is ile(N-MA) or ile(N-linking group-MA) when X 2 is lys; and X 2 is lys(N ε -linking group-MA) when X 1 is ile.