Patent ID: 8058286

Claim:
A method for therapy of a diarrhea-predominant irritable bowel syndrome, comprising administering an effective amount of a morphinan derivative having the nitrogen-containing cyclic substituent of Formula (I): wherein R 1 is C 4 -C 7 cycloalkylalkyl; R 2 and R 3 are independently hydroxy; Y and Z independently represent â€”C(â•O)â€”; â€”Xâ€” represents C 2 alkenylene; k is 2; R 4 s are substituents in the number of k on the nitrogen-containing ring, wherein two R 4 s bound to adjacent carbon atoms, respectively, together form unsubstituted benzo, or cyclohexeno; R 9 is hydrogen; R 10 and R 11 are bound to form â€”Oâ€”: R 12 and R 13 are hydrogen; and the Formula (I) includes (+), (âˆ’) and (Â±) isomers, or a pharmaceutically acceptable acid addition salt thereof.