Patent ID: 7301041

Claim:
A bifunctionalized metallocene of general formula (I): wherein: Me represents a transition metal, Y and Z, which are identical, are chosen from —(CH 2 ) n —O—, —(CH 2 )—O—[(CH 2 ) 2 —O] p — and —(CH 2 ) q —CONH—(CH 2 ) r —O—, or else Y is —(CH 2 ) s —NH— and Z is —(CH 2 ) t —COO—, n is an integer between 3 and 6, p is an integer between 1 and 4, q is an integer between 0 and 2, r is an integer between 0 and 2, s is an integer between 2 and 5, t is an integer between 3 and 6, R and R′ represent hydrogen atoms or are protective groups used in the synthesis of oligonucleotides and peptides, wherein at least one of R or R′ is a protective group used in the synthesis of oligonucleotides and peptides and that R and R′ are as defined below: (i) when Z and Y are chosen from —(CH 2 ) n —O—, —(CH 2 )—O—[(CH 2 ) 2 —O] p — and —(CH 2 ) q —CONH—(CH 2 ) r —O—, then R and R′ are protective groups used in the synthesis of oligonucleotides, and R is a group capable of leaving a free hydroxyl group after deprotection and R′ is a phosphorus group capable of reacting with a free hydroxyl group, and (ii) when Y is —(CH 2 ) s —NH— and Z is —(CH 2 ) t —COO—, then R is a protective group used in the synthesis of peptides and represents a protective group for amines, and R′ represents a hydrogen atom.