Patent ID: 7105671

Claim:
A compound of the formula: wherein R 1 and R 2 are independently hydrogen, halo, amino, hydroxyamino, cyano, nitro, lower alkyl, —OR 5 , perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or sulfonamido; R 3 is an unbranched alkyl chain of 4–5 carbon atoms wherein the chain, in combination with the carbon atom it is bonded to, forms a five- or six-membered ring, and one carbon member of the chain is substituted with one moiety selected from the group consisting of hydroxy, oxo, hydroxyimino, methoxyimino, halo, methoxy, and acetoxy, or one carbon member of the chain is disubstituted with one hydroxy and one lower alkyl or is disubstituted with halogen R 4 is or an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amine group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; said mono-substituted heteroaromatic ring being mono-substituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, perfluoro-lower alkyl, amidooxime, n is 0, 1, 2, 3 or 4; R 5 is hydrogen, lower alkyl, or perfluoro-lower alkyl; R 6 is lower alkyl; and R 7 is hydrogen or lower alkyl; * denotes a carbon atom that is asymmetric in all or most of the compounds of formula I; or a pharmaceutically acceptable salt thereof.