Patent ID: 7893280

Claim:
A compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Q is trifluoro-methyl phenyl, 3-methyl-4-fluorophenyl, 3-fluorophenyl or 3,5-difluorophenyl; L is Het; wherein Het is (i) an optionally substituted five- or six-membered heterocyclic ring containing at least two double bonds and containing 1, 2, 3 or 4 heteroatoms each independently being selected from N, S or O; (ii) an optionally substituted five- or six-membered heterocyclic ring containing at least two double bonds and containing 1, 2, 3 or 4 heteroatoms each independently being selected where possible from N, S or O and being fused through 2 carbon atoms, 2 nitrogen atoms or 1 carbon and 1 nitrogen atom with another optionally substituted five- or six-membered ring, which contains, apart from the atoms in common with the first ring, only carbon atoms; the latter ring may be unsaturated, partially unsaturated or saturated; wherein Het being a monocyclic ring system may optionally be substituted with up to 4 substituents, said substituents each independently being selected from halo, hydroxy, amino, cyano, carboxyl, mono-or di(C 1-4 alkyl)amino, C 1-6 alkyl, C 1-6 alkyl substituted with hydroxy or C 1-4 alkyloxy or amino or mono-or di(C 1-4 alkyl)amino, polyhaloC 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyloxy, aminocarbonyl, mono-or di(C 1-6 alkyl)aminocarbonyl, C 1-6 alkyl-C(═O)—NH—, C 1-6 alkyloxy-C(═O)—NH—, H 2 N—C(═O)—NH— or mono or di(C 1-4 alkyl)amino-C(═O)—NH—.