Patent ID: 7816406

Claim:
A compound having formula (1): or a pharmaceutically acceptable salt thereof; wherein A is absent if Z 3 is N, and H, halo or C 1-10 alkyl when Z 3 is C; B is absent if Z 1 is N, or is H or halo if Z 1 is C; V is H, halo or C 1-10 alkyl; X is an amino substituent selected from an optionally substituted piperidine, pyrrolidine, piperazine, morpholine, or thiomorpholine ring, or is a C 1-10 thioalkyl group substituted with pyrazine; Z 1 and Z 3 are each independently C or N; Z 2 and Z 4 are both C; Z is NR 1 or S; W together with N and Z form a 5-membered ring that is fused to a phenyl ring of the formula U is NR 1 R 2 or NR 1 —(CR 1 2 ) n —NR 3 R 4 ; in each NR 1 R 2 , R 1 and R 2 together with N form an optionally substituted ring selected from piperidine, pyrrolidine, piperazine, morpholine, and thiomorpholine; in NR 3 R 4 , R 3 and R 4 together with N may form an optionally substituted ring selected from piperidine, pyrrolidine, piperazine, morpholine, and thiomorpholine; R 1 and R 3 are independently H or C 1-6 alkyl; R 4 is H, a C 1-10 alkyl or C 2-10 alkenyl; each R 5 is independently H, amino, alkoxy, amido, halogen, or cyano; or R 5 is C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, each optionally substituted by halo; and n is 1-6.