Patent ID: 6893822

Claim:
A method for enzymatically modifying a conjugate comprising the steps of: providing a conjugate comprising a nucleic acid and a synthetic binding unit, wherein the synthetic binding unit is selected from the group consisting of pRNA, pDNA, and CNA; and contacting the conjugate with at least one enzyme to effect modification of the nucleic acid, wherein when the synthetic binding unit is pRNA or pDNA, the synthetic binding unit and the nucleic acid are connected via a linkage selected from the group consisting of the 2′ end of the synthetic binding unit to the 5′ end of the nucleic acid, 2′ end of the synthetic binding unit to the 3′ end of the nucleic acid, 4′ end of the synthetic binding unit to the 5′ end of the nucleic acid, and 4′ end of the synthetic binding unit to the 3′ end of the nucleic acid.