Patent ID: 7166628

Claim:
A compound of the formula (I) wherein: Ar 1 is carbocycle substituted with one R 1 , and wherein Ar 1 is independently substituted with two R 2 groups; R 1 is NO 2 , —N(R c ) 2 , J-C(O)—N(R c )— or J-S(O) m —N(R c )— m is 0, 1 or 2 and wherein R c is chosen from hydrogen or C1–5 alkyl; J is chosen from C1–10 alkyl and carbocycle each optionally substituted by R b ; R 2 is chosen from C1–6 alkyl or C3–7 cycloalkyl which may optionally be partially or fully halogenated, C1–4 acyl, aroyl, C1–4 alkoxy, which may optionally be partially or fully halogenated, halogen, C1–6 alkoxycarbonyl, carbocyclesulfonyl and —SO 2 —CF 3 ; R 3 , R 4 , R 5 , R 7 and R 8 are each independently chosen from hydrogen, halogen, C1–5 alkyl, C1–5 alkoxy, C1–5 alkylC1–5 alkoxy, hydroxy, hydroxy C1–5 alkyl or amino optionally mono- or di-substituted by C1–5 alkyl, aryl or aryl C1–5 alkyl; R 5 is chosen from a bond, —O—, —S—, —N<, —NH—, C(O), a linear chain chosen from —NH(CR 7 R 8 ) n —, —(CR 7 R 8 ) n —, —O(CR 7 R 8 ) n —, —C(O)—O(CR 7 R 8 ) n —, —S(CR 7 R 8 ) n —, C(O)(CR 7 R 8 ) n — and —C(O)NH(CR 7 R 8 ) n —, wherein n is 1–5 and each of the aforementioned R 5 is further substituted by R a , or R 5 is aryl optionally substituted by R a ; R a and R b are each independently chosen from hydrogen, C1–5 alkyl, hydroxyC1–5 alkyl, C2–5 alkenyl, C2–5 alkynyl, carbocycle, C1–5 alkoxy, C1–5 alkylthio, amino, C1–5 alkylamino, C1–5 dialkylamino, C1–5 acyl, C1–5 alkoxycarbonyl, C1–5 acyloxy, C1–5 acylamino, each of the aforementioned are optionally partially or fully halogenated, or R a and R b are chosen from C1–5 alkylsulphonylamino, hydroxy, oxo, halogen, nitro and nitrile, and each X is independently O or S or the pharmaceutically acceptable salts, acids, esters or isomers thereof.