Patent ID: 8765152

Claim:
A pharmaceutical or nutraceutical formulation, comprising: a core, comprising an active pharmaceutical or nutraceutical ingredient, a penetration promoter, a bioavailability promoting agent, and only one synchronization layer; and a polymeric coating suitable for gastrointestinal targeted release of the active ingredient, wherein the penetration promoter is a copolymer comprising from 30 to 80% by weight of at least one C 1 - to C 4 -alkyl ester of acrylic or of methacrylic acid, and from 70 to 20% by weight of at least one alkyl(meth)acrylate monomer having a tertiary amino group in an alkyl radical, wherein the bioavailability promoting agent is a pharmaceutically acceptable inhibitor of a proteolytic enzyme, and the bioavailability promoting agent is configured to increase oral bioavailability of the active ingredient by a factor of at least five, compared to a corresponding formulation without the bioavailability promoting agent.