Patent ID: 8114847

Claim:
A method of inhibiting translesion DNA replication in a cell containing abasic nucleotides in the DNA, the method comprising administering an agent to the cell, the agent comprising formula (I): where Het is a heterocylic azaindene having the following formula: where R 1 is OH, monophosphate, diphosphate, triphosphate, or OR a , where R a comprises at least one of a straight chain, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, fatty acid residue, or a mono, di, or triphosphate thereof; wherein R 4 , R 5 , and R 6 each independently represent hydrogen, a halo, amino, C 3 -C 20 aryl, C 1 -C 24 alkyl, C 2 -C 24 alkenyl, or carboxyl with the proviso that at least one of R 4 , R 5 and R 6 is other than hydrogen; or a pharmaceutically acceptable salt thereof.