Patent ID: 7569726

Claim:
At least one compound of Formula I: a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer; a chelate thereof, a non-covalent complex thereof, or a mixture of any of the foregoing, wherein: n is 1 to 6; X is —NR a —, wherein R a is H; each instance of R 1 and R 2 is independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R 1 and R 2 , together with the carbon to which they are attached, can join to form a 3-6 membered optionally substituted ring comprising 0, 1, or 2 heteroatoms selected from O, N, and S; R 3 is selected from OH, SH, NH 2 , lower alkyl, substituted lower alkyl, lower alkoxy, substituted lower alkoxy, or sulfanyl; R 4 is OH; R 5 , R 6 , R 7 , and R 8 are independently selected from H, Cl, F, Br, I, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, NR b R c , C(O)OR 9 , OR 9 , SR 9 , SO 2 R 9 , CN, NO 2 , aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, alkoxycarbonyl, substituted alkoxycarbonyl, haloalkyl, perhaloalkyl, or —Y—R 10 , wherein: Y is selected from —N(R 11 )—Z— or —Z—N(R 11 )—; Z is selected from C(O), SO 2 , alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, or substituted alkynylene; R 9 is selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl; R 10 is selected from H, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 11 is selected from H, lower alkyl, or substituted lower alkyl; and R b and R c are independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R b and R c can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring, wherein, the compound is other than 2-(3-hydroxy-1-oxo-1H-indene-2-carboxamido)acetic acid or a methyl, ethyl, or propyl ester thereof.