Patent ID: 7037924

Claim:
A compound of formula (I): R 1 is —COOH, -lower alkyl-COOH, -lower alcohol, —CH 2 OCH 3 , —CH 2 NH 2 , —CH 2 NHSO 2 R 7 , —C(═O)R 8 , —CNHCH 2 CH 2 —R 8 , —C(═NH)—R 8 , —(CH 2 ) n NHC(═O)R 9 , —(CH 2 ) m C(═O)N(R 11 )(R 12 ), —C(═NH)—R 13 , or —(CH 2 ) n —R 14 ; R 2 is wherein X is —CH or —N; R 3 , R 4 , R 5 , and R 6 are each selected from the group consisting of —H, -lower alkyl, —N(CH 3 ) 2 , —N(CH 3 )CH 2 CH 3 , —N(CH 2 CH 3 )CH 2 CH 3 , -halo, —O-lower alkene, -lower alkoxy, —O-lower alcohol, and —O(CH 2 ) n -cycloalkyl; or where R 5 and R 6 are substituents on adjacent ring carbon atoms, optionally R 5 and R 6 together with the C atoms to which they are attached form a 5 or 6 membered saturated carbocyclic ring; R 7 is —CF 3 , -lower alkyl, —CH 2 Cl, —CH 2 CF 3 , or —R 8 ; R 8 is a 5 or 6 membered saturated substituted or unsubstituted heterocyclic ring containing one hetero atom which is selected from N, O, and S wherein the substituted ring is the heterocyclic ring substituted with —OH or -phenyl; R 9 is -lower alkyl, -lower alkoxy, or —(CH 2 ) n R 10 ; R 10 is a 5 or 6 membered saturated or unsaturated heterocyclic ring containing one or two hetero atoms which are selected from N and O; R 11 is —H or —CH 3 ; R 12 is —H, -lower alkyl, —C≡N, —OH, -lower alkoxy, or —CH 2 COOCH 2 CH 3 ; R 13 is -lower alkoxy, —NH 2 or —N-lower alkyl; R 14 is a saturated or unsaturated 5 membered substituted or unsubstituted heterocyclic ring containing from 1 to 4 hetero atoms wherein the hetero atoms are selected from N, O and S, wherein the substituted ring is the heterocyclic ring which is substituted at one or two ring carbons with ═O, or substituted at a ring N with -lower alcohol or -lower alkyl; m is 0, 1 or 2; n is 0 or 1; or a pharmaceutically acceptable salt or ester thereof.