Patent ID: 8188125

Claim:
A method for treating a disease or disorder chosen from skeletal muscle and myocardial ischemia, stroke, coronary artery disease, peripheral vascular disease, and coronary artery disease, comprising administering to a human in need thereof a compound of the formula: wherein R is a unit chosen from: i) hydrogen; ii) substituted or unsubstituted phenyl; and iii) substituted or unsubstituted heteroaryl ring; Z is a substituted or unsubstituted [1,3,4]thiadiazol-2-yl unit having the formula: R 1 is chosen from: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted C 6 or C 10 aryl; iv) —OR 4 ; v) —C(O)OR 5 ; yl) —COR 6 ; vii) —NR 7 C(O)OR 8 ; and viii) substituted or unsubstituted heteroaryl; R 4 is hydrogen or substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; R 5 is C 1 -C 6 linear or branched alkyl, or benzyl; R 6 is C 1 -C 6 linear, branched, or cyclic alkyl, or phenyl; R 7 is hydrogen or methyl; R 8 is C 1 -C 6 linear or branched alkyl, or benzyl; L is a unit having the formula —[C(R 9a R 9b )] y —; R 9a and R 9b are each independently hydrogen, C 1 -C 6 linear or branched alkyl, or phenyl; and the index x is 0 or 1; the index y is from 1 to 4; or a pharmaceutically acceptable salt thereof.