Patent ID: 8318947

Claim:
A process of preparing a compound of Formula (V): comprising the steps of: a) condensing R 10 R 20 NH or a salt thereof with a 2-chloro-2-oxoacetate ester having the formula: in the presence of a tertiary amine base and a solvent or solvent mixture comprising one or more of toluene, o-xylene, m-xylene, p-xylene, and nitrobenzene, to form a solution of a 2-oxoacetate ester having the formula: wherein R is C 1 -C 4 linear or branched alkyl; and b) reacting the solution of the 2-oxoacetate ester formed in step (a) with R 30 R 40 NH or salt thereof to form the compound of Formula (V); wherein R 10 and R 30 are each independently selected from the group consisting of optionally substituted arylalkyl, optionally substituted heteroarylalkyl, and optionally substituted hetero-cycle alkyl; and R 20 and R 40 are each independently H or optionally substituted C1-C3 alkyl.