Patent ID: 7973079

Claim:
A pharmaceutical composition comprising a compound of Formula (I): wherein: A is O, NH, or S; B is a bond, —(C 2 -C 7 )alkyl, —(C 2 -C 7 )alkenyl, —(C 3 -C 8 )cycloalkyl, —(C 3 -C 8 )heterocycloalkyl, —(C 3 -C 8 )cycloalkenyl, or —(C 3 -C 8 )heterocycloalkenyl; D is isopropyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, methylenecyclopropyl, methylenecyclobutyl, or methylenecyclopentyl; E is (C═O)—OR, —O—(C═O)—R, —(C═O)—R, —OR, a carboxylic acid bioisostere, —(C═O)—NR 1 R, NR 1 —(C═O)—R, —(C 1 -C 7 )alkyl-(C═O)—OR, or —(C 1 -C 7 )alkyl-(C═O)—NR 1 R; R is H or G is —OR 1 , —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-OR 1 , halogen, —CO 2 R 1 , —(C 1 -C 6 )alkyl-CO 2 R 1 , NHR 1 , —(C 1 -C 6 )alkyl-NHR 1 , —(C═O)NHR 1 , —(C 1 -C 6 )alkyl-(C═O)NHR 1 , —NHR 1 (C═O)R 1 , or —(C 1 -C 6 )alkyl-NHR 1 (C═O)R 1 ; R 1 is H or (C 1 -C 6 )alkyl; and X is a halogen; or a pharmaceutically acceptable prodrug, salt thereof; and a pharmaceutically acceptable excipient.