Patent ID: 8071113

Claim:
Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and nucleic acid molecules from the species Shigella dysenteriae serotype 1 that share at least about 90% sequence identity with the nucleic acid molecule of SEQ ID NO:1 or 2; and b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2 and nucleic acid molecules from the species Shigella dysenteriae serotype 1 that share at least about 90% sequence identity with the nucleic acid molecule of SEQ ID NO:1 or 2.