Patent ID: 7659287

Claim:
A compound having the formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, wherein: R 1 is —OH; R 2 is (C 1 -C 3 )alkyl; R 3 is (C 1 -C 3 )haloalkyl; R 4 is a member selected from the group consisting of hydrogen, halogen, (C 1 -C 8 )alkyl and (C 3 -C 8 )cycloalkyl; R 5 is selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, and (C 3 -C 8 )cycloalkyl, wherein any cycloalkyl portion is optionally substituted with from one to two members selected from the group consisting of halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 2 -C 4 )hydroxyalkyl, and (C 1 -C 4 )alkoxy; X is selected from the group consisting of a bond, (C 1 -C 8 )alkylene, (C 0 -C 8 )alkylene-SO 2 , and (C 0 -C 8 )alkylene-C(O); Y is selected from the group consisting of H, —CN, —N(R′) 2 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )heterocycloalkyl, heteroaryl, and aryl, wherein any cycloalkyl portion, heterocycloalkyl portion, aryl portion or heteroaryl portion is optionally substituted with from one to four members selected from the group consisting of halogen, —CN, —NO 2 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, ═O, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, aryl, heteroaryl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )heterocycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, (C 3 -C 8 )heterocycloalkyl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl or aryl(C 1 -C 6 )alkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR′, —OR′, —SR′, —OC(O)R′, —C(O)N(R′) 2 , —S(O)R′, —SO 2 R′, —SO 2 N(R′) 2 , —N(R′) 2 , —NR′C(O)R′, —NR′SO 2 R′, —Z—C(O)R′, —Z—CN, —Z—C(O)OR′, —Z—NR′C(O)OR′, —Z—OR′, —Z—OC(O)R′, —Z—C(O)N(R′) 2 , —Z—S(O)R′, —Z—SO 2 R′, —Z—SO 2 N(R′) 2 , —Z—N(R′) 2 and —Z—NR′C(O)R′; R 6 to R 9 are members independently selected from hydrogen and (C 1 -C 8 )alkyl; Z is a branched or straight chain (C 1 -C 8 )alkylene group; and each occurrence of R′ is independently H or an unsubstituted member selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, or two R′ groups, when attached to the same nitrogen atom, can be combined with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl group.