Patent ID: 7902182

Claim:
A compound of formula I R 1 is (Ar 1 )alkyl; R 2 is hydrogen, alkyl, hydroxy, or alkoxy; R 3 is SO 2 N(R 6 )(R 7 ); R 4 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, or haloalkoxy; R 5 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, or haloalkoxy; R 6 and R 7 taken together with the nitrogen to which they are attached is azetidinyl, (R 8 )-azetidinyl, pyrrolidinyl, (R 8 )-pyrrolidinyl, piperidinyl, (R 8 )-piperidinyl, dialkylpiperidinyl, trialkylpiperidinyl, piperazinyl, 4-(R 9 )-piperazinyl, dialkylpiperazinyl, dialkyl-4-(R 9 )-piperazinyl, homopiperidinyl, morpholinyl, thiomorpholinyl, R 8 is alkyl, hydroxy, alkoxy, amino, alkylamino, dialklyamino, alkylCONH, alkylCON(alkyl), (methylthio)tetrahydrofuranyl, (amino)tetrahydrofuranyl, (alkylamino)tetrahydrofuranyl, (dialkylamino)tetrahydrofuranyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, homopiperidinyl, morpholinyl, (azetidinyl)alkyl, (pyrrolidinyl)alkyl, (piperidinyl)alkyl, (piperazinyl)alkyl, (homopiperidinyl)alkyl, or (morpholinyl)alkyl; R 9 is alkyl, (cycloalkyl)alkyl, SO 2 R 10 , or COR 11 ; R 10 is hydrogen, alkyl, amino, alkylamino, dialkylamino, azetidinyl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperizinyl, 4-(alkyl)piperizinyl, morpholinyl, or thiomorpholinyl; R 11 is hydrogen, alkyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, azetidinyl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperizinyl, 4-(alkyl)piperizinyl, morpholinyl, or thiomorpholinyl; R 12 is hydrogen or alkyl; R 13 is hydrogen or alkyl; Ar 1 is and X-Y-Z is C(R 12 ) 2 OC(R 12 ) 2 C(R 12 ) 2 ; or a pharmaceutically acceptable salt thereof.