Patent ID: 7531505

Claim:
A biofunctional coating composition comprising at least one binding domain that specifically binds to a metallic surface material of a medical device (“surface-binding domain”), and at least one binding domain that specifically binds to cells of endothelial cell lineage (“endothelial-binding domain”); wherein the surface-binding domain comprises a peptide having a length of 16 to 60 amino acids comprising SEQ ID NO:5, and wherein the peptide can be modified to comprise one or more terminal modifications, and a modification to facilitate linking; wherein the endothelial-binding domain comprises a peptide having a length of 18 to 60 amino acids comprising SEQ ID NO:19; and wherein the peptide can be modified to comprise one or more terminal modifications, and a modification to facilitate linking, or one or more conservative substitutions in SEQ ID NO:19, and wherein the surface-binding domain is coupled to the endothelial-binding domain.