Patent ID: 8071339

Claim:
A method for producing L-histidine comprising cultivating a bacterium of the Enterobacteriaceae family in a culture medium, allowing said L-histidine to accumulate in the culture medium, and collecting said L-histidine from the culture medium, wherein said bacterium contains a DNA encoding a mutant phosphoribosylpyrophosphate synthetase (PRPP synthetase) comprising a) an amino acid sequence of a wild-type bacterial phosphoribosylpyrophosphate synthetase comprising the sequence of SEQ ID NO: 2, except that the aspartic acid at position 115 is substituted with another L-amino acid, or b) the mutant phosphoribosylpyrophosphate synthetase as described in (a), wherein one or more amino acids other than the aspartic acid at position 115 are deleted, substituted, inserted, or added, wherein said amino acid sequence is at least 95% homologous with respect to the entire amino acid sequence of SEQ ID NO: 2, wherein said phosphoribosylpyrophosphate synthetase activity is maintained, and feedback inhibition by purine nucleotides is desensitized.