Patent ID: 8642610

Claim:
A method of treating cancer in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of having the general structure of formula I, wherein R 1 , R 3 , and R 4 are independently selected from the group consisting of NO 2 , H, halo, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 5 -C 7 aryl, mono-, di- or tri-chloro, and mono-, di- or tri-methyl, R 2 is H, or R 3 and R 2 taken together with the atoms to which they are attached form an optionally substituted heterocyclic fused ring, or R 3 and R 4 taken together with the atoms to which they are attached form an optionally substituted cycloalkyl fused ring; X is selected from the group consisting of NR 5 , and —(NH(CH 2 ) n )—; wherein n is 1 or 2; Z is selected from the group consisting of a bond, CO, C 1 -C 4 alkyl, C 1 -C 4 alkenyl, and C 1 -C 4 alkynyl; and R 5 is H, or R 3 and R 5 taken together with the atoms to which they are attached form an optionally substituted heterocyclic fused ring; thereby treating cancer in a subject; and wherein said cancer is colorectal cancer.