Patent ID: 8372592

Claim:
A method of detecting a change in a cell growth pattern comprising: a) adding one or more B-cells to a colorimetric resonant reflectance optical biosensor, wherein one or more one or more adhesion proteins are immobilized on a location on the biosensor surface, and wherein the one or more B-cells express a receptor that specifically binds the one or more adhesion proteins; c) detecting a first colorimetric resonant reflectance optical peak wavelength value (PWV) for the location; d) applying one or more test reagents to the one or more B-cells and incubating the one or more cells for a period of time; e) detecting a second PWV for the location; and f) comparing the first PWV and second PWV; wherein a difference between the first PWV in relation to the second PWV indicates a change in the cell growth pattern in the one or more B-cells.