Patent ID: 8604053

Claim:
A compound having formula (I-i) or a pharmaceutically acceptable thereof, wherein R A is methyl, NH 2 , or Cl; p is 0 or 1; R x , at each occurrence, represents optional substituent(s) on any substitutable position of the bicyclic ring selected from the group consisting of alkyl, halogen, haloalkyl, OH, O(alkyl), O(haloalkyl), NH 2 , N(H)(alkyl), and N(alkyl) 2 ; R 2 and R 3 are the same or different, and are each independently hydrogen, C 1 -C 5 alkyl, or haloalkyl; or R 2 and R 3 , together with the carbon atom to which they are attached, form a C 3 -C 6 monocyclic cycloalkyl ring, optionally substituted with 1, 2, or 3 substituents selected from the group consisting of alkyl and halogen; R 4 , at each occurrence, represents optional substituent(s) on any substitutable position of the bicyclic ring selected from the group consisting of alkyl, halogen, haloalkyl, O(alkyl), O(haloalkyl), and SCF 3 ; and m and n are each independently 0, 1, 2, or 3; with the proviso that the compound is other than N-(7-tert-butyl-3,4-dihydro-2H-chromen-4-yl)-N′-(3-methylisoquinolin-5-yl)urea; N-(6-fluoro-3,4-dihydro-2H-chromen-4-yl)-N′-(3-methylisoquinolin-5-yl)urea; or N-(6-methyl-3,4-dihydro-2H-chromen-4-yl)-N′-(3-methylisoquinolin-5-yl)urea.