Patent ID: 7309696

Claim:
A compound having the structure of Formula III: wherein, R 11 is (C 1 -C 16 ) alkyl, branched alkyl, alkenyl or alkynyl; R 12 is (C 1 -C 16 ) alkyl, branched alkyl, alkenyl or alkynyl; X 11 is O, S, or NHC═O; X 12 is O, S, or NHC═O; X 13 is O or S; n is 0, 1 or 2, and R 13 is an anticancer agent, wherein, each and alkynyl of R 11 , R 12 , and R 13 is, optionally, substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of halo, nitro, trifluoromethyl, (C 1 -C 8 ) alkyl, (C 1 -C 8 ) alkoxy, aryl, and N(R a )(R b ) wherein R a and R b are each independently selected from the group consisting of H and (C 1 -C 8 ) alkyl, and wherein, if n is 1 or 2, the compound is a phospholipase C substrate and is not a phospholipase A substrate, and further wherein, if n is 1 or 2, the compound is converted to an alkyl lipid and a moiety selected from the group consisting of a nucleoside monophosphate and a nucleoside analogue monophosphate intracellularly in a mammal, and is not converted to an alkyl lipid and a moiety selected from the group consisting of a nucleoside monophosphate and a nucleoside analogue monophosphate extracellularly in a mammal.