Patent ID: 7202329

Claim:
An isolated protein complex having a first protein interacting with a second protein, said first protein being selected from the group consisting of: (a) Tsg101, (b) a Tsg101 fragment that comprises a UEV domain and interacts with an HIV GAGp6 late domain, (c) a first polypeptide that interacts with an HIV GAGp6 late domain and has an amino acid sequence that is at least about 75% identical to (a) or (b), and (d) a first fusion protein comprising (a), (b), or (c); and said second protein being selected from the group consisting of: (i) HIV GAG, (ii) a fragment of HIV GAG that comprises an HIV GAGp6 late domain and interacts with Tsg101, (iii) a second polypeptide that interacts with Tsg101 and has an amino acid sequence that is at least about 75% identical to that of (i) or (ii), and (iv) a second fusion protein comprising (i), (ii), or (iii).