Patent ID: 7868008

Claim:
A compound selected from the group consisting of: 7-Chloro-2-[(4,4-difluorocyclohexyl)methyl]-1-oxoisoindoline-5-carbonitrile, 7-Chloro-5-[5-(4-hydroxy-piperidin-1-ylmethyl)[1,2,4]oxadiazol-3-yl]-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one, 7-Chloro-5-[5-(4-oxo-piperidin-1-ylmethyl)-[1,2,4]oxadiazol-3-yl]-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one, 7-Chloro-5-[5-(4-fluoro-piperidin-1-ylmethyl)[1,2,4]oxadiazol-3-yl]-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one, 7-Chloro-2-(4,4-difluoro-cyclohexyl-methyl)-5-[5-(4-fluoro-piperidin-1-ylmethyl)-[1,2,4]oxadiazol-3-yl]-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(2-fluorobenzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(3-fluoro-benzyl)-piperidin-4-yl methyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(2-methoxy-benzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(3-methoxy-benzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(4-methoxy-benzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(4-fluoro-benzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclohexylmethyl-5-[1-(3-fluoro-benzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclohexylmethyl-5-[1-(4-fluoro-benzyl)-piperidin-4-ylmethyl]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(3-fluoro-benzyl)-piperidin-4-ylmethoxy]-7-methyl-2,3-dihydro-isoindol-1-one, 2-Cyclopropylmethyl-5-[1-(4-methoxybenzyl)-piperidin-4-ylmethoxy]-7-methyl-2,3-dihydro-isoindol-1-one, 5-(1-Benzyl-pyrrolidin-3-ylamino)-7-methyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one, 4-{4-[7-Chloro-1-oxo-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-1H-isoindol-5-ylmethyl]-piperidin-1-ylmethyl}-benzonitrile, 4-[4-(7-Chloro-2-cyclopropylmethyl-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl)-piperidine-1-ylmethyl]-benzonitrile, 4-{4-[7-Chloro-2-(4-chloro-benzyl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-piperidin-1-ylmethyl}-benzonitrile, 4-{4-[7-Chloro-2-(4-difluoromethoxy-benzyl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-piperidin-1-ylmethyl}-benzonitrile, 4-{4-[7-Chloro-2-(4-ethyl-benzyl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-piperidin-1-ylmethyl}-benzonitrile, 4-{4-[7-Chloro-1-oxo-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-1H-isoindol-5-ylmethyl]-piperazin-1-methyl}-nicotinonitrile, 3-{3-[1-(7-Chloro-2-cyclopropylmethyl-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl)-piperidin-4-yl]-propyl}-benzonitrile, 7-Chloro-2-cyclopropylmethyl-1-oxo-2,3-dihydro-1H-isoindole-5-carbonitrile, 5-Fluoro-2-(4-ethyl-benzyl)-7-trifluoromethyl-2,3-dihydro-isoindol-1-one, 5,7-Dimethoxy-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one, 5,7-Dimethoxy-2-(4-chloro-benzyl)-2,3-dihydro-isoindol-1-one, and 5,7-Dimethoxy-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one; or a pharmaceutically acceptable salt, optical isomer, or combination thereof.