Patent ID: 8003700

Claim:
A solid complex, comprising: colchicine and a guest, wherein the guest is malic acid, oxalic acid, or para-toluenesulfonic acid; and wherein the solid complex comprising colchicine and malic acid comprises a colchicine malic acid co-crystal comprising XRPD peak positions at 6.0, 7.2, 8.5, 11.1, 13.1, 16.3, 16.7, 18.4, 19.9, 22.0, and 24.6±0.2 degrees 2-theta; wherein the solid complex comprising colchicine and oxalic acid comprises a colchicine oxalic acid co-crystal comprising XRPD peak positions at 7.4, 9.2, 9.4, 10.8, 12.0, 12.3, 14.4, 15.9, 17.8, 18.9, 20.5, and 23.7±0.2 degrees 2-theta or an XRPD pattern comprising the peaks of FIG. 5 ; and wherein the solid complex comprising colchicine and para-toluenesulfonic acid comprises a colchicine para-toluenesulfonic acid co-crystal comprising XRPD peak positions at 6.6, 6.8, 9.6, 12.8, 14.3, 15.1, 17.1, 18.6, and 22.7±0.2 degrees 2-theta.