Patent ID: 8765722

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is -(L 1 ) m -(L 2 ) n -X 1 ; L 1 is selected from the group consisting of alkynylene and arylene; m is 1; L 2 is selected from the group consisting of —NHC(O)— and alkylene; n is 0 or 1; X 1 is selected from the group consisting of a) —P(O)R x R y , b) —P(O)OR x R y , c) —OP(O)R x R y and d) optionally substituted C 1-12 alkyl, and 5-10 membered heteroaryl comprising one to three nitrogen atoms; each of R x and R y independently is selected from the group consisting of H, C 1-12 alkyl, and C 6-14 aryl; when X 1 is selected from d) and is substituted, X 1 is substituted with one or more halogen; R 2 is optionally substituted C 3-12 cycloalkyl; wherein, when R 2 is substituted, R 2 is substituted with one or more Q 2 ; where each Q 2 individually is selected from the group consisting of —OH, and optionally substituted C 1-6 alkyl; when Q 2 is substituted, Q 2 is substituted with one or more halogen; R 3 is -(L 3 ) p -(L 4 ) q -(X 3 ); L 3 is selected from the group consisting of optionally substituted C 1-12 alkylene, optionally substituted C 3-12 cycloalkylene and optionally substituted 5-6 membered N-containing heterocyclylene; p is 0 or 1; when L 3 is substituted, L 3 is substituted with one or more Q 3 , each Q 3 individually is selected from the group consisting of —OH and C 1-6 alkyloxy; L 4 is selected from the group consisting of —NH—, and C 1-12 alkylene; q is 0, 1 or 2; X 3 is selected from the group consisting of: e) —P(O)R x R y , f) —P(O)OR x R y , g) —OP(O)R x R y , h) —P(O)(OR x )(OR y ), wherein each A is a 4 to 6 membered ring, including the depicted P atom, and k) optionally substituted C 3-12 cycloalkyl, and optionally substituted 3-12 membered heterocyclyl; each of R x and R y individually is as defined above; and when X 3 is selected from k) and is substituted, X 3 is substituted with one —OH; provided that when X 1 is selected from d), then X 3 is selected from the group consisting of e), f), g), h), and i).