Patent ID: 8586756

Claim:
A process for the preparation of a 2,2-difluoroethylamine derivative of formula (IV) and/or a salt thereof which comprises the following steps (i) and (ii): step (i): reaction of N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (I) with a compound of formula (II) A-CH 2 -E (II) to give a compound of formula (III) optionally in the presence of an inorganic or organic base, in which, in the formulae (II), (III) and (IV), A is pyrid-2-yl, pyrid-4-yl or pyrid-3-yl, which can optionally be substituted in the 6-position by fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy, or is 1,3-thiazol-5-yl, which can be substituted in the 2-position by chlorine or methyl, or is pyrid-3-yl of the following formula in which X is halogen, C 1 -C 12 -alkyl or C 1 -C 12 -haloalkyl and Y is halogen, C 1 -C 12 -alkyl, C 1 -C 12 -haloalkyl, C 1 -C 12 -haloalkoxy, azido or cyano, and, in formula (II), E is a leaving group chosen from chlorine, bromine or iodine or an activated hydroxyl compound, mesylate, tosylate and SO 2 CH 3 , and step (ii): removal of the allyl group from the compound of the formula (III) obtained in step (i), by which a difluoroethylamine derivative of the formula (IV) and/or a salt thereof is obtained, optionally in the presence of a catalyst and optionally in the presence of a nucleophile.