Patent ID: 7737137

Claim:
A method inhibiting 11-β-HSD-1 enzyme comprising administering to the mammal an effective amount of a selective inhibitor of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme activity, wherein the inhibitor is a compound of formula (I) wherein n is 1; R 1 is cycloalkyl or heterocycle, selected from the group consisting of each of which is independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, alkenyl, haloalkyl, Cl, Br, F, I, —CN, —NO 2 , —OR b , —SR b , —S(O)R Z , —S(O) 2 R Z , —NR a R b , —C(O)R b , —C(O)OR b , —C(O)NR a R b , —S(O) 2 NR a R b , —C(═NOH)NH 2 , —C(═NH)NH 2 , R c , and —(CR d R e ) m —CN; R 2 and R 3 , at each occurrence, are each independently hydrogen or alkyl; R 4 is —(CR d R e ) m -E-G, wherein E, at each occurrence, is independently O or N(R e ), -and G, at each occurrence, is independently unsubstituted or substituted phenyl or pyridinyl; R a , at each occurrence, is independently hydrogen or alkyl; R b , at each occurrence, is independently hydrogen, alkyl, haloalkyl, R c , or (CR d R e ) m —R c ; R Z , at each occurrence, is independently alkyl, haloalkyl, R c or —(CR d R e ) m —R c ; R c , at each occurrence, is independently heteroaryl, wherein the heteroaryl is imidazolyl, triazolyl or tetrazolyl; R d and R e , at each occurrence, are independently hydrogen or alkyl; and m is 1; or a pharmaceutically acceptable salt, or a combination thereof.