Patent ID: 8048289

Claim:
A system for high-throughput analysis of membranous samples having ion channels, the system comprising: at least one membranous sample; a multi-compartment structure including an extracellular chamber, an opposing intracellular chamber and a partition separating the extracellular and intracellular chambers, the partition having a plurality of apertures fluidly and electrically coupling the extracellular and intracellular chambers, at least one of the apertures being sealed by the at least one membranous sample having a seal resistance in a range between about 100 to about 1000 Mohms, another of the apertures being unsealed, the unsealed aperture having an aperture resistance less then the seal resistance by about two orders of magnitude; an electric source configured to apply a voltage and/or a current between the extracellular and intracellular chambers, wherein a portion of current travels through the unsealed aperture creating an electrical leak; and an electronic detector with a leak subtraction data acquisition protocol for making a measurement while the portion of current travels through the at least one unsealed aperture, whereby the electrical leak value is subtracted from a measured data.