Patent ID: 7563894

Claim:
A compound having the structure of Formula (1) or Formula (46): wherein: Ar is selected from an optionally substituted five-membered aromatic heterocycle, an optionally substituted five-membered aromatic carbocycle, an optionally substituted six-membered aromatic heterocycle, and a substituted, optionally further substituted phenyl; Q is selected from the group consisting of Q is selected from the group consisting of wherein: R A is selected from —NH 2 , —NEt 2 , and —NH(CH 2 ) n OH, and n is 1 to; R B is selected from the group consisting of —CH 2 OH, —CH 2 CH 2 OH, and —CH 2 CH 2 CH 2 OH; R C is at 2, 3, or 4 position of the piperidine ring; and R C is selected from the group consisting of —C(O)NHEt, —C(O)NEt 2 , c-butyl, c-pentyl, —C(O)NH-thiazole, oxazole, thiazole, —S(O) 2 NH 2 , —S(O) 2 NHEt, and —S(O) 2 NEt 2 ; each R D is independently selected from —(CH 2 ) k OH or —(CH 2 ) k CO 2 H, and k is 1 to 6; R E is at 2, 3, or 4 position of the piperidine ring; and R E is selected from the group consisting of —C(O)NH 2 , —C(O)NHEt, and —C(O)NEt 2 , and R F is thiazole, pyrazole, or isoxazole; each R 1 is independently selected from the group consisting of H, halogen, and an optionally substituted moiety selected from -L 1 -alkyl, -L 1 -cycloalkyl, -L 1 -heteroalkyl, -L 1 -haloalkyl, -L 1 -aryl, -L 1 -heterocycloalkyl, and -L 1 -heteroaryl; wherein L 1 is selected from a bond, —O—, —NH—, —S—, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 —, —C(O)NH(CR″ 2 ) 1-6 C(O)O—, —C(O)NR″NR″C(O)O—, and —S(O)NH—; each R″ is independently H, OH, halogen, C 1-6 alkyl, substituted C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkyl, halo-C 1-6 alkoxy, aryl, haloaryl, or heteroaryl; or any two adjacent R 1 groups together may form an optionally substituted 5 to 8-membered heterocyclic, cycloalkyl, or aryl ring; R 5 is selected from the group consisting of hydrogen and C 1-6 alkyl; or a pharmaceutically acceptable salt or pharmaceutically acceptable N-oxide thereof.