Patent ID: 8304411

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: R is the following formula: wherein: R 5 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl and heterocyclic alkyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl or heterocyclic alkyl is independently unsubstituted or substituted with one or more groups independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, alkoxyl, cycloalkoxyl, aryloxyl, heteroaryloxyl, halogen, hydroxyl, amino, alkylamino, cyano, hydroxyalkyl, heterocyclic alkyl, heterocyclic alkoxyl, carboxylic acid and carboxylic ester; R 6 and R 7 are each independently selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, haloalkyl, haloalkoxyl, hydroxy, amino, cyano, alkynyl, alkoxyl, aryloxyl, hydroxyalkyl, heterocyclic alkyl, carboxylic acid, carboxylic ester and halogen; and W is C, S or O, wherein C is unsubstituted or substituted with R 6 or R 7 R 1 is selected from the group consisting of —C(O)NR 3 R 4 , —C(O)R 3 and —C(O)OR 3 ; R 2 is selected from the group consisting of hydrogen, unsubstituted or substituted cycloalkyl, and alkyl, wherein the alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of cycloalkyl and aryl; R 3 and R 4 are either each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl and heterocyclic alkyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl or heterocyclic alkyl is independently unsubstituted or substituted with one or more groups independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, alkoxyl, cycloalkoxyl, aryloxyl, heteroaryloxyl, halogen, hydroxyl, amino, cyano, hydroxyalkyl, heterocyclic alkyl, heterocyclic alkoxyl, trifluoromethyl, carboxylic acid and carboxylic ester; or R 3 and R 4 , together with the N atom to which they are attached, form a 3- to 8-membered heterocyclic ring, wherein the 3- to 8-membered heterocyclic ring further contains zero or more heteroatoms selected from N, O and S, and the 3- to 8-membered ring is unsubstituted or substituted with one or more groups independently selected from the group consisting of alkyl, aryl, heteroaryl, haloalkyl, haloalkoxyl, hydroxyl, amino, cyano, alkoxyl, aryloxyl, hydroxyalkyl, heterocyclic alkyl, carboxylic acid, carboxylic ester, and halogen; and n is an integer from 0 to 4.