Patent ID: 8362251

Claim:
A compound having the following Formula (II) or pharmaceutically acceptable salts thereof: which is an intermediate in the synthesis of the following compound: wherein: is a single bond or a double bond; X and Y are each independently selected from C or N; X and Y are N, wherein R5 and R7 are absent; R 1 is selected from H, alkyl, cycloalkyl, hetereocyclo alkyl, aryl, heteroaryl, alkoxyl, aryoxyl, —COOR 9 , —CONR 9 R 10 , —C(═S)NR 9 R 10 , —COR 9 , —SOR 9 , —SO 2 R 9 , —SO 2 NR 9 R 10 and —P(═O)(OR 9 ) (OR 10 ); R 2 is H; R 3 is selected from alkyl, trifluoromethyl, aryl and aralkyl; wherein said alkyl, aryl and aralkyl are each optionally substituted by one or more halogen and hydroxyl; R 4 is selected from alkyl, cycloalkyl, hetereocyclo alkyl, aryl, heteroaryl, —(CH 2 ) n (OCH 2 CH 2 ) r R 11 , —[CH 2 CH(OH)] r CH 2 NR 9 R 10 and —(CH 2 ) n NR 9 R 10 ; wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclo alkyl are each optionally substituted by one more groups selected from the group consisting of aryl, hydroxyl, amino, amide group, aminocarbonyl, alkoxyl, aryoxyl, aminoalkyl, hydroxyalkyl, heterocyclo alkyl, carboxylic acid, carboxylic ester and —NR 9 R 10 ; X and Y are C, wherein R 5 , R 6 , R 7 , R 8 are each independently selected from hydrogen, halo, haloalkoxyl, alkyl, cycloalkyl, heterocyclo alkyl, alkenyl, alkynyl, aryl, heteroaryl, hydroxyl, —OR 9 , —O[CH 2 CH 2 O] r R 11 , —SR 9 , —NR 9 R 10 , —SOR 9 , —SO 2 R 9 , —NHSO 2 R 9 , —SO 2 NR 9 R 10 , —(CH 2 ) n CO 2 R 9 , —(CH 2 ) n CONR 9 R 10 , —C(═S)NR 9 R 10 , —COR 9 , —NR 9 COR 10 , —NHCO 2 R 10 , —OCO 2 R 9 , —OCO 2 NR 9 R 10 , —CN and —NO 2 , wherein said aryl, heteroaryl, cycloalkyl, heterocyclo alkyl are substituted by one more groups consisting of alkyl, alkoxyl and halogen; R 9 and R 10 are each independently selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl and heterocyclo alkyl, wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclo alkyl are each substituted by one more groups consisting of alkyl, aryl, hydroxyl, amino, amide group, aminocarbonyl, cyano, alkoxyl, aryoxyl, aminoalkyl, hydroxyalkyl, heterocyclo alkyl, carboxylic acid and carboxylic ester; R 9 and R 10 are taken together with the atom to which they are attached to form 4 and 8 membered rings, wherein the 5 to 8 membered rings further optionally contain one to three heteroatoms selected from the group consisting of N, O and S, and the 4 to 8 membered rings so formed are optionally substituted by one more groups consisting of alkyl, aryl, heteroaryl, haloalkyl, haloalkoxyl, hydroxyl, amino, amide group, cyano, alkoxyl, aryoxyl, aminoalkyl, hydroxyalkyl, heterocyclo alkyl, carboxylic acid, carboxylic ester, halogen and —NR 9 R 10 ; R 11 is hydrogen or alkyl; R 12 is hydrogen or aldehyde; n is 2-6; and r is 1-6.