Patent ID: 7747395

Claim:
A method for the design and identification of a potential binding compound for human peptide deformylase (HsPDF) comprising the steps of: (a) generating, on a computer, a three-dimensional structure of HsPDF having the structural coordinates of Tables 1 and/or 2; (b) identifying amino acid residues forming an HsPDF active site from the three-dimensional structure of HsPDF from step (a) in order to generate a three-dimensional model of the HsPDF active site, wherein the HsPDF active site comprises amino acids 50 CVGLSAPQ 57 (SEQ ID NO:10), 112 EGCES 116 (SEQ ID NO:12), and 156 HEMDHL 161 (SEQ ID NO:13), and 176 TNVYWMKVND 185 (SEQ ID NO:8) according to Table 1 and/or 2; (c) designing and/or selecting a compound that potentially binds to the HsPDF active site using the three-dimensional model of the HsPDF active site; and (d) synthesizing and/or choosing the potential binding compound.