Patent ID: 8763410

Claim:
An apparatus comprising: a vial configured to contain a hyperpolarized agent therein; a dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel configured to hold water; a sliding seal unit positioned between the pressure vessel and the vial configured to seal a cryogenically cooled chamber containing the vial therein from an ambient environment without contacting contents of the vial; a delivery fluid path having a first end and a second end, the first end hermetically attached to the vial configured to transport therefrom an aqueous solution of the hyperpolarized agent and wherein the dissolution fluid path and delivery fluid path comprise tubular structures and the dissolution fluid path is positioned internal to or parallel to the delivery fluid path and wherein the sliding seal unit is positioned about the dissolution and delivery fluid paths; a dynamic particle size exclusion filter having a first end and a second end, the first end connected to the second end of the delivery fluid path; a receiver connected to the second end of the dynamic particle size exclusion filter positioned and configured to receive the filtered aqueous solution of the hyperpolarized agent and configured to hold a dissolution medium; and wherein the dynamic particle size exclusion filter is positioned and configured to remove at least one of an electron paramagnetic agent (EPA) and a processing agent from the hyperpolarized solution based on when the pH value of the solution is approximately less than 4 before said hyperpolarized solution enters the receiver, further wherein the electron paramagnetic agent (EPA) comprises tris{8-carboxyl-2,2,6,6-tetra[2-(1-methoxyethyl)]-benzo(1,2-d:4,5-d′)bis(1,3)dithiole-4-yl}methyl sodium salt.