Patent ID: 7435797

Claim:
An isolated antibody that is capable of binding to the extracellular domain of HER2, which comprises an antibody light chain variable domain of SEQ ID NO: 1, and an antibody heavy chain variable domain of SEQ ID NO: 2, wherein the light chain variable domain of SEQ ID NO: 1 comprises an amino acid substitution selected from the group consisting of N30(V L )S; T31(V L )S; Y49(V L )D, and Y49(V L )W numbered according to the Kabat numbering system, and the heavy chain variable domain of SEQ ID NO: 2 comprises an amino acid substitution selected from the group consisting of D98(V H )W, F100(V H )P; Y102(V H )K; and Y102(V H )L, numbered according to the Kabat numbering system.