Patent ID: 8716473

Claim:
A compound of the formula (1): or a salt or tautomer thereof; wherein: X 1 is N or N + (O − ); X 2 is N or CH; Q is a C 1-3 alkylene group; R 1 is selected from hydrogen, C 1-4 hydrocarbyl and hydroxy-C 2-4 hydrocarbyl; R 2 , R 3 and R 4 are the same or different and each is selected from hydrogen, fluorine, chlorine and methyl; Ar 1 is a monocyclic 5 or 6-membered aryl or heteroaryl ring containing 0, 1 or 2 heteroatom ring members selected from O, N and S, or a naphthyl ring, the aryl or heteroaryl or naphthyl ring being optionally substituted with 1, 2 or 3 substituents selected from fluorine; chlorine; bromine; C 1-4 hydrocarbyl; C 1-4 hydrocarbyloxy; trifluoromethyl; difluoromethyl; hydroxy; cyano; trifluoromethoxy; difluoromethoxy; amino; mono-C 1-4 hydrocarbylamino; di-C 1-4 hydrocarbylamino; C 1-4 hydrocarbyl-C(O)—; C 1-4 hydrocarbyl-C(O)-amino; C 1-4 hydrocarbylsulphonylamino; C 1-4 hydrocarbylureido; sulphamoyl; mono-C 1-4 hydrocarbylsulphamoyl; di-C 1-4 hydrocarbylsulphamoyl; carbamoyl; mono-C 1-4 hydrocarbyl carbamoyl; di-C 1-4 hydrocarbyl carbamoyl; a group O—(CH 2 ) k —OR 5 ; and a group O m —(CH 2 ) n —NR 6 R 7 ; N2 to 4; m is 0 or 1 and n is 0, 1, 2, 3 or 4 provided that when m is 1 then n is at least 2; R 5 is hydrogen or C 1-4 hydrocarbyl; R 6 is hydrogen or C 1-4 hydrocarbyl; R 7 is hydrogen or C 1-4 hydrocarbyl; or NR 6 R 7 forms a saturated five or six membered heterocyclic ring optionally containing a further heteroatom selected from O, N and S or oxidised forms thereof, the heterocyclic ring being optionally substituted with 1 to 4 C 1-4 hydrocarbyl groups or hydroxy; Ar 2 is a monocyclic 5 or 6-membered heteroaryl ring containing 1, 2 or 3 heteroatom ring members selected from O, N and S and being optionally substituted with 1, 2 or 3 substituents selected from fluorine; chlorine; bromine; C 1-4 hydrocarbyl; C 1-4 alkoxy; trifluoromethyl; difluoromethyl; hydroxy; cyano; trifluoromethoxy; difluoromethoxy; amino; mono-C 1-4 hydrocarbylamino; di-C 1-4 hydrocarbylamino; C 1-4 hydrocarbyl-C(O)—; C 1-4 hydrocarbyl-C(O)-amino; C 1-4 hydrocarbylsulphonylamino; C 1-4 hydrocarbylureido; sulphamoyl; mono-C 1-4 hydrocarbylsulphamoyl; di-C 1-4 hydrocarbylsulphamoyl; carbamoyl; mono-C 1-4 hydrocarbyl carbamoyl; and di-C 1-4 hydrocarbyl carbamoyl; and wherein, in each substituent consisting of or containing C 1-4 hydrocarbyl, the C 1-4 hydrocarbyl is selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, cyclopropyl and cyclopropylmethyl.