Patent ID: 8506511

Claim:
An extracorporeal blood circuit comprising: a withdrawal conduit connectable to a coronary withdrawal catheter positionable in or proximate to a chamber of a heart of a patient and adapted to receive a flow of blood from the patient; a withdrawal pump connectable to the withdrawal conduit, wherein a pumping rate of the withdrawal pump determines a blood withdrawal rate from the coronary withdrawal catheter; at least one filter having an input connectable to the withdrawal conduit and a blood output connectable to an infusion conduit and a filtrate output connectable to a filtrate conduit, wherein the filtrate removed by the at least one filter is a total amount of filtrate removed from the blood by the blood circuit; a filtrate measurement device to determine a weight of filtrate removed from the blood in the filter; a replacement fluid conduit adapted to provide a replacement fluid to at least one of the withdrawal conduit, filter and infusion conduit; a replacement fluid pump connectable to the replacement fluid conduit, wherein a pumping rate of the replacement fluid pump determines a rate at which the replacement fluid flows into the blood flowing through the blood circuit; a controller for regulating the pumping rate of the replacement fluid pump such that the rate of the replacement fluid provides an amount of replacement fluid to the at least one of the withdrawal conduit, filter and infusion conduit, wherein the controller determines a total amount of filtrate removed based on the weight of the filtrate removed from the blood, and adjusts the pumping rate such that the amount of infused replacement fluid is commensurate with the amount of filtrate removed throughout the extracorporeal blood circuit while the replacement fluid is being added to the at least one of the withdrawal conduit, filter and infusion conduit, and the infusion conduit connectable to a catheter insertable into the patient to infuse filtered blood and the replacement fluid to the patient while the filtrate is being removed and the blood flows into the withdrawal catheter.