Patent ID: 7494824

Claim:
A method of binding, cleaving, or otherwise modifying a target substance in a liquid comprising providing an interactive system comprising: (a) a surface of a plastic material selected from the group consisting of a poly(meth)acrylate polymer, a polyvinyl ester polymer, copolymers thereof, and a mixture of at least one polyalkyl(meth)acrylate with one or more of the group consisting of polystyrene, polyacrylonitrile, polycarbonate, and polysulfone; the material containing at least one structural element (A) which is the ester group of the acrylate or vinylester polymer, and (b) a linker coupled to a pharmaceutically or physiologically active substance, the linker selected from the group consisting of a (poly)alkylene glycol, a (poly)alkylene imine, a (poly)alkylene amine, a polyoxazilin and a (poly)alkylene sulfide, wherein the linker is attached to the structural element (A) on the surface of the plastic material by a hydrogen bond which cannot be reversed by pH values in the range of 2 to 13 or temperatures up to 60° C., and wherein the pharmaceutically or physiologically active substance is capable, to bind, cleave or otherwise modify the target substance; and contacting the liquid with the interactive system whereby the target substance is bound, cleaved or otherwise modified.