Patent ID: 8729072

Claim:
A compound selected from Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R 1 , R 2 and R 3 are independently selected from H, F, Cl, —NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —OH, —OCH 3 , —OCH 2 CH 3 , —OCH 2 CH 2 OH, and C 1 -C 3 alkyl; R 4 is selected from H, F, Cl, CN, —CH 2 OH, —CH(CH 3 )OH, —C(CH 3 ) 2 OH, —CH(CF 3 )OH, —CH 2 F, —CHF 2 , —CH 2 CHF 2 , —CF 3 , —C(O)NH 2 , —C(O)NHCH 3 , —C(O)N(CH 3 ) 2 , —NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —NHC(O)CH 3 , —OH, —OCH 3 , —OCH 2 CH 3 , —OCH 2 CH 2 OH, cyclopropyl, cyclopropylmethyl, 1-hydroxycyclopropyl, imidazolyl, pyrazolyl, 3-hydroxy-oxetan-3-yl, oxetan-3-yl, and azetidin-1-yl; R 5 is selected from —CH 3 , and —CH 2 CH 3 ; n is 1, 2, 3, or 4; R 6 is selected from H, —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 OH, —NH 2 , and —OH; R 7 is selected from the structures: where the wavy line indicates the site of attachment; R 8 is selected from —CH 3 , —S(O) 2 CH 3 , cyclopropyl, azetidin-3-yl, oxetan-3-yl, and morpholin-4-yl; X 1 is CR 9 or N, where R 9 is selected from H, F, Cl, —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 OH, —NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —OH, —OCH 3 , —OCH 2 CH 3 , and —OCH 2 CH 2 OH; X 2 is CR 10 or N, where R 10 is selected from H, —CH 3 , —CH 2 CH 3 , and —CH 2 CH 2 OH; and Y 1 and Y 2 are independently selected from CH and N, where Y 1 and Y 2 are not each N.