Patent ID: 7504507

Claim:
A compound of the formula I in which positional numbering, where mentioned, refers to the system illustrated above, and one or more Z are attached to a ring carbon or carbons at any of positions 6 to 10, and in which: Q is O or S; W is C(═Q)NR-M-(CH 2 ) m R 1 , in which M is CHJ or G, R is H or an optionally substituted C 1-4 alkyl group, J is H or an optionally substituted C 1 -C 6 alkyl group, G is an optionally substituted fully saturated, or partially unsaturated, or aromatic, carbocycle or heterocycle, R 1 is C(NR 2 )NH 2 , NHC(═NR 3 )NH 2 or NR 4 R 5 , in which each of R 2 and R 3 are independently H or an optionally substituted C 1-4 alkyl group, R 4 and R 5 are independently H or an optionally substituted C 1-4 alkyl group or R 4 and R 5 together with the nitrogen atom to which they are attached form an optionally substituted, saturated or unsaturated heterocyclic group, and m is an integer from 0 to 6; Y is H, C 1-6 alkyl or (CH 2 ) n —X—(CH 2 ) p U, in which X is CH 2 , C═O, CH═CH, O, S, NR or G; and n and p are integers from 0 to 6, and U is H, CF 3 , halo, NR 4 R 5 , + NRR 4 R 5 , cyano, C(═O)NR 4 R 5 , OR 4 , CO 2 R 5 , G, NR 4 G or OG; and Z is H, halo, OH, CO 2 H, CO 2 R 4 , SO 2 R 4 , NR 4 R 5 , nitro, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 aminoalkyl, C 1-6 aminoalkoxy, or aza functionality replacing a ring CH functionality, or a carbon or carbon/nitrogen framework bridging the 6-7,7-8 or 8-9 positions so as to form an additional fused 5 to 6-membered carbocycle or heterocycle; or a pharmaceutically-acceptable salt thereof.