Patent ID: 8163762

Claim:
A compound of formula I: wherein: R 2 is R—NR′, wherein R and R′ taken together with atoms bound thereto form a pyrrolidin-1-yl moiety substituted at the 2-position by a hydroxymethyl group or R′ is hydrogen and R is an amino substituted straight or branched alkyl containing three to five carbons; R 6 is benzylamino; and R 9 is a straight or branched alkyl or alkenyl, excluding methyl or is R—CHR′ wherein R and R′, together with atoms bound thereto, form a optionally substituted cycloalkyl; and each optionally substituted by one or more hydroxy, halogen, or amino groups, and wherein said compound has an IC 50 less than or equal to 5 μM for cdc2/cyclin B extracted or purified from the starfish Marthasterias glacialis.