Patent ID: 8026384

Claim:
A process for the synthesis of a compound of formula I wherein R 1 is selected from hydrogen; C 1 -C 10 -alkyl; C 1 -C 10 -alkoxy; fluorine; and chlorine; R 2 is selected from hydroxy; fluorine; chlorine; oxo; and C 1 -C 10 -alkoxy; R 3 is selected from hydrogen and C 1 -C 6 -alkyl; R 4 is selected from hydrogen and C(O)R 5 ; R 5 is selected from C 1 -C 10 alkyl and C 1 -C 10 alkoxy; comprising reacting a compound of formula II wherein R 6 is selected from hydrogen; C 1 -C 10 -alkyl; C 1 -C 10 -alkoxy; fluorine; and chlorine; R 7 is selected from hydroxy; fluorine; chlorine; oxo; and C 1 -C 10 -alkoxy; R 8 is selected from hydrogen and C 1 -C 6 -alkyl; R 9 is selected from hydrogen and C(O)R 10 ; R 10 is selected from C 1 -C 10 alkyl and C 1 -C 10 alkoxy; and X is iodide or bromide; with a compound of formula III wherein R 11 and R 12 are each and independently selected from C 1 -C 10 alkyl and Si(R 13 ) 3 ; and R 13 is a C 1 -C 6 alkyl; in the presence of an amine and an amineoxide.