Patent ID: 8378121

Claim:
A compound of formula I: in salt or zwitterionic form, wherein: a and b are independently 0 or an integer of from 1 to 5; each R 1 and R 2 is independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —C 3-6 cycloalkyl, cyano, halo, —OR a , —CH 2 OH, —COOH, —C(O)—O—C 1-4 alkyl, —C(O)NR b R c , —SR a , —S(O)R a , —S(O) 2 R a , and —NR b R c ; where each R a is independently selected from hydrogen, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl and —C 3-6 cycloalkyl; each R b and R c is independently selected from hydrogen, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; or R b and R c together with the nitrogen atom to which they are attached form a C 3-6 heterocycle; or two adjacent R 1 groups or two adjacent R 2 groups are joined together to form —C 3-6 alkylene, —C 2-4 alkylene-O— or —O—C 1-4 alkylene-O—; R 3 is —OH; c is 0 or an integer of from 1 to 3; each R 4 is independently fluoro or —C 1-4 alkyl; d is 1, and depicts an optional double bond; R 5 is selected from —C 1-6 alkyl, —CH 2 —C 2-6 alkenyl, —CH 2 —C 2-6 alkynyl, and —CH 2 COR 5a ; where R 5a is selected from —OH, —O—C 1-6 alkyl, and —NR 5b R 5c ; and R 5b and R 5a are independently selected from H and —C 1-6 alkyl; Q is —C 0-5 alkylene-Q′-C 0-1 alkylene-, wherein Q′ is selected from —CH 2 —, —CH═CH—, —C≡C—, —O—, —S—, —S(O)—, —SO 2 —, —SO 2 —NR Q1 -, —NR Q1 SO 2 —, —C(O)—, —OC(O)—, —C(O)O—, —NR Q1 C(O)—, —C(O)NR Q1 —, —NR Q2 —C(O)—NR Q3 —, —NR Q2 —C(S)—NR Q3 —, —C═N—O—, —S—S—, and —C(═N—O—R Q4 )—, where R Q1 is hydrogen or —C 1-4 alkyl, R Q2 and R Q3 are independently selected from hydrogen, —C 1-4 alkyl, and —C 3-6 cycloalkyl, or R Q2 and R Q3 are taken together to form —C 2-4 alkylene or —C 2-3 alkenylene, and R Q4 is —C 1-4 alkyl or benzyl; e is 0 or an integer of from 1 to 5; each R 6 is independently selected from halo, —C 1-4 alkyl, —C 0-4 alkylene-OH, cyano, —C 0-2 alkylene-COOH, —C(O)O—C 1-4 alkyl, —O—C 1-4 alkyl, —S—C 1-4 alkyl, —NH—C(O)—C 1-4 alkyl, —N(C 1-4 alkyl) 2 , and —N + (O)O; wherein each alkyl, alkenyl, alkylene, alkynyl and cycloalkyl group in R 1-3 , R 3a-3c , R 4-6 , and R a- R c is optionally substituted with 1 to 5 fluoro atoms; wherein each alkyl, alkenyl, and alkynyl group in R 5 is optionally substituted with 1 to 2 substituents independently selected from —O—C 1-6 alkyl, —OH and phenyl; each cycloalkyl, aryl, heteroaryl and heterocycle group in R 1-2 , R 3a-3c , and R a-c is option ally substituted with 1 to 3 substituents independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, cyano, halo, —O—C 1-4 alkyl, —S—C 1-4 alkyl, —S(O)(C 1-4 alkyl), —S(O) 2 (C 1-4 alkyl), —NH 2 , —NH(C 1-4 alkyl) and —N(C 1-4 alkyl) 2 , wherein each alkyl, alkenyl and alkynyl group is optionally substituted with 1 to 5 fluoro substituents; and each —CH 2 — group in Q is optionally substituted with 1 or 2 substituents independently selected from —C 1-2 alkyl, —OH and fluoro; or a pharmaceutically acceptable salt thereof.