Patent ID: 7892550

Claim:
An isolated anti-c-met antibody comprising a light chain variable region comprising three light chain hypervariable region (HVR) sequences and a heavy chain comprising three heavy chain HVR sequences, wherein at least one HVR is a variant of SEQ ID NO: 2, 4, 5, or 143, wherein: (a) HVR-L1 comprises sequence A1-A17, wherein A1-A17 is KSSQSLLYTSSQKNYLA (SEQ ID NO:1); (b) HVR-L2 comprises sequence B1-B7, wherein B1-B7 is WASTRES (SEQ ID NO:2), or a variant thereof, wherein said variant comprises 1-7 (1, 2, 3, 4, 5, 6, or 7) substitutions in any combination of the following positions: B1 (M or L), B2 (P, T, G or S), B3 (N, G, R or T), B4 (I, N or F), B5 (P, I, L or G), B6 (A, D, T or V) and B7 (R, I, M or G); (c) HVR-L3 comprises sequence C1-C9, wherein C1-C9 is QQYYAYPWT (SEQ ID NO:3); (d) HVR-H1 comprises sequence D1-D10, wherein D1-D10 is GYTFTSYWLH (SEQ ID NO:4), or a variant thereof, wherein said variant comprises 1-5 (1, 2, 3, 4 or 5) substitutions in any combination of the following positions: D3 (N, P, L, S, A, I), D5 (I, S or Y), D6 (G, D, T, K, R), D7 (F, H, R, S, T or V) and D9 (M or V); (e) HVR-H2 comprises sequence E1-E18, wherein E1-E18 is GMIDPSNSDTRFNPNFKD (SEQ ID NO:5), or a variant thereof, wherein said variant comprises 1-8 (1, 2, 3, 4, 5, 6, 7 or 8) substitutions in any combination of the following positions: E7 (Y), E9 (I), E10 (I), E14 (T or Q), E15 (D, K, S, T or V), E16 (L), E17 (E, H, N, Q or D) and E18 (Y, E or H); and (f) HVR-H3 comprises sequence F1-F11, wherein F1-F11 is SYGSYVSPLDY (SEQ ID NO:143), or a variant thereof, wherein said variant comprises 1-8 (1, 2, 3, 4, 5, 6, 7, or 8) substitutions in any combination of the following positions: F1 (T), F3 (R, S), F4 (G), F6 (R, F, M, T, E, K, A, L, W), F7 (L, I, T, R, K, V), F8 (S, A), F10 (Y, N) and F11 (Q, S, H, F).