Patent ID: 8287907

Claim:
A method of preparing a biorelevant gastrointestinal medium, comprising: providing a homogeneous solid dissolution composition in a granular or powder form comprising at least one bile salt and at least one phospholipid; forming an aqueous medium containing at least one buffer component and at least one osmotic agent; adding the homogeneous solid dissolution composition to the aqueous medium wherein the at least one bile salt and at least one phospholipid have a mole ratio between about 1:1 and 20:1; and producing a biorelevant gastrointestinal medium as a dispersion or solution, the biorelevant gastrointestinal medium having: 0.1% w/v to 5% w/v of the at least one bile salt and the at least one phospholipid; micelles or mixed micelles with mean particle diameters below 100 nm; a pH between about pH 1 and pH 10; an osmolality less than about 800 mOsmol/kg; and adding at least one of a pharmacological compound, a physiological compound and a dosage form to the biorelevant gastrointestinal medium to determine a solubility or dissolution characteristic of the pharmacological compound, physiological compound or dosage form.