Patent ID: 6844364

Claim:
A method of enhancing the stability during administeration of multiple unit dosages of a compound of Formula I: wherein R 1 is hydrogen or C 1-6 -alkyl; R 2 is C 1-6 -alkyl or adamantyl; R 3 is C 1-6 -alkyl or hydroxy; or R 2 and R 3 taken together are —(CR 6 R 7 ) n —; R 4 is C 2-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, —OCH 2 R 5 or C 2-8 -alkanoyl, or hydrogen when R 3 is hydroxy; R 5 is C 1-6 -alkyl, C 2-6 -alkenyl or C 2-6 -alkynyl; R 6 and R 7 are hydrogen or C 1-6 -alkyl; Y is oxygen or sulfur; and n is 3, 4, or 5, or a pharmaceutically acceptable salts of carboxylic acid of formula I, wherein said method comprises the step of admixing multiple unit dosages of said compound in solid form with a topical carrier to form a topical formulation within forty-eight hours prior to first topical administration of said formulation, and refrigerating said formulation during the course of administration of said multiple unit dosages.