Patent ID: 8268850

Claim:
A compound of Formula I: in which L is a 5 member heteroaryl ring containing 3 nitrogen atoms selected from: R 1 , R 2a and R 2b are each independently selected from hydrogen, C 3-8 heterocycloalkyl, C 1-4 alkyl, C 1-4 alkoxy, halo-substituted-C 1-4 alkoxy, halo-substituted-C 1-4 alkyl, —NR 10 R 11 , —OX 1 R 8 ; wherein X 1 is selected from a bond and C 1-4 alkylene; R 8 is C 3-12 cycloalkyl; or R 1 and R 2a or R 1 and R 2b together with the carbon atoms to which R 1 and R 2a or R 2b are attached form phenyl; R 10 and R 11 are independently selected from hydrogen, C 1-4 alkyl, C 1-4 alkoxy, halo-substituted-C 1-4 alkoxy, halo-substituted-C 1-4 alkyl, C 3-8 heterocycloalkyl, C 1-10 heteroaryl; or R 10 and R 11 together with the nitrogen to which R 10 and R 11 are both attached form C 3-8 heterocycloalkyl or C 1-10 heteroaryl; R 3 is selected from is C 6-10 aryl, C 1-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 3 is substituted with 1 to 3 radicals independently selected from hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 6-10 aryl-C 0-4 alkyl, heteroaryl, heterocyclyl, —X 2 NR 5a R 5b , —X 2 NR 5a OR 5b , —X 2 C(O)R 5a , —X 2 S(O) 0-2 R 5a , —X 2 OX 3 R 5a , —X 2 R 5a , —X 2 C(O)OR 5a , —X 2 OR 5a and —X 2 OX 3 OR 5a ; wherein X 2 and X 3 are independently selected from a bond and C 1-4 alkylene; and R 5a and R 5b are each independently selected from hydrogen, C 1-6 alkyl, C 6-10 aryl, C 3-12 cycloalkyl, C 1-10 heteroaryl and C 3-12 heterocycloalkyl; wherein said aryl, cycloalkyl, heteroaryl or heterocycloalkyl substituents of R 3 can optionally be further substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —X 4 OR 6 , —X 4 C(O)OR 6 , —X 4 C(O)NR 6 R 6 and X 4 R 6 ; wherein X 4 is selected from a bond and C 1-4 alkylene; and R 6 is selected from hydrogen, C 1-6 alkyl and C 3-12 heterocycloalkyl; and the pharmaceutically acceptable salts thereof.