Patent ID: 7045533

Claim:
A compound of formula I wherein X is —S—, —S(O)—, —S(O) 2 —, —S(O) 2 NH—, —P(O)(OCH 3 )—, —P(O)(OH)—, —NH—, —N(CH 3 )—, —NHC(O)NH—, —C(O)—, —C(O)O—, —NHC(O)—, —CH(OH)—, —CH═N—, —CH═CH—, —CH 2 NH— or —C(═NH)—; R 1 is aryl or heteroaryl; R 2 is hydrogen, OR 4 or NR 5 R 6 ; R 4 is C 1 –C 8 alkyl or C 2 –C 8 alkenyl; R 5 and R 6 independently are hydrogen, C 1 –C 8 alkyl or C(O)C 1 –C 8 alkyl; and R 3 is hydrogen, cyano, heteroaryl, heterocycloalkyl, C(O)R 7 , OR 8 or NR 9 R 10 ; R 7 is OH, C 1 –C 4 alkoxy, NH 2 , NHCH 2 C(O)OH or aryl; R 8 is hydrogen, C 1 –C 8 alkyl, C(O)C 1 –C 4 alkyl or C(O)-aryl; and R 9 and R 10 independently are hydrogen, C 1 –C 8 alkyl or C 2 –C 4 alkenyl; with the proviso that when X is —C(O)— and R 2 and R 3 are hydrogen or R 2 is H and R 3 is 4-methoxy, R 1 is not 1-naphthyl nor 4-methoxy-1-naphtyl nor phenyl; in free base or acid addition salt form.