Patent ID: 8131332

Claim:
A method of determining a state of health of an individual, where “state of health” is any of (i) a disease state based on long-term changes (greater than one month duration) in tissue, (ii) a measure of chemical change based on long-term (greater than one month duration) glycemic control, (iii) a measure of glycation end-products in tissue, and (iv) a combination of the above, comprising: (a) illuminating a portion of a tissue of the individual with excitation light; (b) detecting light emitted from the tissue by fluorescence of a chemical within the tissue, where the tissue is not the lens of the eye; (c) acquiring biologic information relating to the individual, wherein the biologic information comprises one or more of: gender of the individual, height of the individual, weight of the individual, waist circumference of the individual, history of disease in the individual's family, ethnicity, skin melanin content, and smoking history of the individual; (d) determining the state of health from the detected light and a model relating tissue fluorescence and biologic information to a state of health.