Patent ID: 8609111

Claim:
A method of treating Clostridium difficile ( C. difficile ) disease in a subject, the method comprising administering to the subject: (a) an isolated monoclonal antibody that binds to C. difficile toxin A, or an antigen binding portion thereof, wherein the antibody binds to the same epitope of C. difficile toxin A recognized by an antibody comprising a heavy and light chain variable region having the amino acid sequences set forth in SEQ ID NOs: 1 and 4, SEQ ID NOs: 2 and 5, or SEQ ID NOs: 3 and 6, respectively; and (b) an isolated monoclonal antibody that binds to C. difficile toxin B, or an antigen binding portion thereof, wherein the antibody binds to the same epitope of C. difficile toxin B recognized by an antibody comprising a heavy and light chain variable region having the amino acid sequences set forth in SEQ ID NOs: 54 and 58, respectively, wherein C. difficile disease is treated in the subject.