Patent ID: 8507512

Claim:
A compound of structural Formula I: or a pharmaceutically acceptable salt thereof, wherein: W is selected from the group consisting of CH and N; Z is selected from the group consisting of: R 1 is selected from the group consisting of —OH, —OC 1-6 alkyl and —N(R 5 ) 2 ; R 2 is selected from the group consisting of —C 1-2 perfluoroalkyl and —NH 2 ; R 3 is selected from the group consisting of: 1) —C 1-6 alkyl substituted with 1-3 of —F, 2) —COR 4 and 3) —SO 2 R 6 ; R 3a is selected from the group consisting of —H; —C 1-3 alkyl; C 3-6 cycloalkyl optionally mono- or di-substituted with one or more substituents selected from the group consisting of —CH 3 and —F; and —CH 2 —C 3-6 cycloalkyl optionally mono- or di-substituted with one or more substituents selected from the group consisting of —CH 3 and —F; R 4 is selected from the group consisting of: 1) —H, 2) —C 1-3 alkyl, 3) —OC 1-3 alkyl 4) —C 3-6 cycloalkyl optionally mono- or di-substituted with one or more substituents selected from the group consisting of —CH 3 and —F, 5) —CH 2 —C 3-6 cycloalkyl optionally mono- or di-substituted with one or more substituents selected from the group consisting of —CH 3 and —F, 6) —OC 3-6 cycloalkyl optionally mono- or di-substituted with one or more substituents selected from the group consisting of —CH 3 and —F, and 7) —N(R 5 ) 2 ; R 5 is independently selected at each occurrence from —H and —C 1-3 alkyl; R 6 is selected from the group consisting of —C 1-3 alkyl; —C 3-6 cycloalkyl optionally mono- or di- substituted with one or more substituents selected from the group consisting of —CH 3 and —F; and —CH 2 —C 3-6 cycloalkyl optionally mono- or di-substituted with one or more substituents selected from the group consisting of —CH 3 and —F; R 7 is selected from the group consisting of —H and —CH 3 ; R a and R b are independently selected at each occurrence from —F, —Cl and —Cl 1-3 alkyl optionally substituted with 1-3 of —F; and R c and R d are independently selected at each occurrence from —F, —Cl and —C 1-3 alkyl optionally substituted with 1-3 of —F.