Patent ID: 8183248

Claim:
A compound selected from Formula I: in which n is selected from 0, 1 and 2; m is selected from 0, 1 and 2; Y 1 is selected from N and CR 5 ; Y 2 is selected from O and S; R 1 is selected from hydrogen and C 1-6 alkyl; R 2 is selected from hydrogen and C 1-6 alkyl; R 3 is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 4 is selected from —NR 5 C(O)R 6 and —C(O)NR 5 R 6 ; wherein R 5 is selected from hydrogen and C 1-6 alkyl; and R 6 is selected from C 6-10 -aryl, C 6-10 -aryl-C 1-4 alkyl, C 5-10 heteroaryl, C 5-10 heteroaryl-C 1-4 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-4 alkyl, C 3-10 heterocycloalkyl, and C 3-10 heterocycloalkyl-C 1-4 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 6 is optionally substituted with 1 to 3 substituents selected from halo, hydroxy, —NR 5 R 5 , C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 5-10 heteroaryl, C 5-10 heteroaryl-C 1-4 alkyl, C 3-8 heterocycloalkyl, and C 3-8 heterocycloalkyl-C 1-4 alkyl, and C 3-8 heterocycloalkyl-C 1-4 alkoxy; wherein any heteroaryl or heterocycloalkyl substituent of R 6 is optionally substituted by 1 to 3 substituents independently selected from C 1-6 alkyl and hydroxy-C 1-6 alkyl; and R 7 is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 6-10 aryl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl, C 5-10 heteroaryl-C 1-4 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-4 alkyl, C 3-10 heterocycloalkyl, and C 3-10 heterocycloalkyl-C 0-4 alkyl; or a pharmaceutically acceptable salt and stereoisomer thereof.