Patent ID: 8273913

Claim:
A process for preparing a compound of formula I: comprising amidating a salt of formula IIA or an acid of formula IIB with 1-aminocyclopropane carbonitrile, in the presence of a coupling agent, wherein the coupling agent is a carbodiimide, a phosphonium salt or a uronium salt; a base, wherein the base is N-methyl morpholine, TEA, N-ethyldiisopropylamine, 2,6-lutidine, 2,4,6 collidine or 1-methylpiperidine; a solvent, wherein the solvent is DMF, DMAc, NMP, acetonitrile, THF or DMSO; and an activating agent; wherein R 1 is C 1-6 alkyl or C 1-6 haloalkyl; R 2 is C 1-6 alkyl or C 1-6 haloalkyl; R 3 is SO m (C 1-6 alkyl); X is a tertiary amine, a secondary amine or a metal salt; and m is an integer from zero to two.