Patent ID: 7612036

Claim:
A compound of the formula (I): wherein A is 3,6-linked 9H carbazole; Q is hydrogen; Z is —CH 2′ R 2 is selected from hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, —N(R 13 ) 2 and —N(R 12 )—COCHR 2a R 2b ; where R 2a and R 2b are selected from hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, —N(R 13 ) 2 and —N(R 12 )—COR 14 ; where each R 13 is independently selected from hydrogen and C 1 -C 6 alkyl, and where R 12 and R 13 are selected from hydrogen and C 1 -C 6 alkyl, and where R 14 is selected from hydrogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy and —NR 12 ; R 3 , R 4 and R 5 are independently selected from hydrogen and C 1 -C 6 alkyl; R 6 is —CO 2 R 15 , —CONHR 16 , —CONHOR 16 , —CONHNHR 16 , —SO 2 N(R 16 ) 2 , —SO 2 R 17 or —P(O)(OR 18 )(OR 18 ) where each R 15 , R 16 , R 17 and R 18 is independently selected from hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 6 -C 10 aryl and C 7 -C 10 arylalkyl; W is —O— or CR 10 R 11 where R 10 and R 11 are independently selected from hydrogen, hydroxy, C 1 -C 6 alkyl, C 6 -C 10 aryl, C 1 -C 6 alkoxy and —N(R 13 ) 2 and where each R 13 is independently selected from hydrogen and C 1 -C 6 alkyl, and where R 12 is selected from hydrogen and C 1 -C 6 alkyl; Y is an unsubsitituted amino group or a guanidino group, or their hydrochloride salts; is a single or double bond; R 7 and R 8a are hydrogen or are absent if is a double bond; and R 8b and R 9 are hydrogen and X is —(CR 10 R 11 ) u —, —O(CH 2 ) u —, —CH═CH—, —O(CR 10 R 11 )CH═CH—or —CR 10 R 11 —CH═CH— where R 10 and R 11 hydrogen and u is an integer selected from 2 to 3 or R 8b and R 9 together form a covalent bond between X and the carbon to which R 8b is attached, and X is selected from —(CR 10 R 11 ) x — or —O(CH 2 ) x — wherein R 10 and R 11 are hydrogen and x is an integer from 1 to 4; m, and t are independently selected from 0 or 1; r is 1; p is an integer selected from 0 to 6, provided that when W is —O—, p is at least 1; and q is independently selected from 0 to 4; or a pharmaceutically acceptable salt thereof.