Patent ID: 7449483

Claim:
A compound selected from the group consisting of compounds of formula (I) wherein U is a lone pair, Y is CR 1 , Z is S or S(O 2 ), V is —CH 2 —, and m+n≦2, Q is phenyl optionally substituted by 1 to 3 substituents independently selected from the group as defined for R 3 , A 1 is hydrogen, lower-alkenyl, or lower-alkyl substituted with hydroxy, lower-alkoxy, A 2 is cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkinyl, heteroaryl, or lower-alkyl optionally substituted with halogen, hydroxy, or lower-alkoxy, or A 1 and A 2 are bonded to each other to form a ring and -A 1 -A 2 - is lower-alkylene, or lower-alkenylene, optionally substituted by R 4 , in which one —CH 2 — group of -A 1 -A 2 - can optionally be replaced by a NR 5 , S, or O, or -A 1 -A 2 - is —CH═N═CH═CH— which can optionally be substituted by lower-alkyl, A 3 and A 4 independently from each other are hydrogen or lower-alkyl, X is hydrogen R 1 is lower-alkyl, R 3 is halogen, piperidyl, piperazinyl, piperazinyl-ethanone, morpholinyl, CONH 2 , CN, NO 2 , CF 3 , OH, lower-alkoxy, thio-lower-alkoxy, or is lower-alkyl, lower-alkenyl, or lower-alkinyl, optionally substituted with OH or SH, R 4 is hydroxy, lower-alkyl, lower-alkoxy, or thio-lower-alkoxy, R 5 is hydrogen or lower-alkyl, pharmaceutically acceptable salts of compounds of formula (I); and pharmaceutically acceptable esters of compounds of formula (I).