Patent ID: 8703741

Claim:
A method for reducing articular pain in a human being, the method comprising administering a mixture locally to a joint affected by pain via intra-articular injection, wherein the mixture comprises: a vanilloid receptor agonist selected from the group consisting of capsaicin, trans-8-methyl-N-vanillyl-6-nonenamides, N-vannillyl-noneamides, beta-aminoethyl-substituted phenyl-alkanamides, methylene-substituted N-phenylmethyl-alkanamides, N-((substituted-phenyl)methyl)-cis-monounsaturated alkenamides, beta-aminoethyl-substituted phenyl compounds, N-((substituted phenyl)methyl)diunsaturated amides, anandamide, N-oleoyldopamine, transcapsaicin, cis-capsaicin, civamides, SDZ-249-665, DA-5016, Arvanil, dihydrocapsaicin, resiniferatoxin, beta-1-4-glucuronate-beta-1-3-N-acetylglucosamine, isovelleral, olvanil, phorbol 12,13-didecanoate 20 homovanillate, phorbol 12,13-dinonanoate 20 homovanillate, and tinyatoxin; and a glycosaminoglycan or proteoglycan selected from the group consisting of keratan, chondroitin sulfate, heparan sulfate, N-keratan sulfate, O-keratan sulfate, decorin, perlecan, dermatan sulfate, serglycine, sydecan, versican, and hyaluronic acid; wherein the vanilloid receptor agonist and the glycosaminoglycan or proteoglycan are dissolved in a solvent, which is compatible with the human being, to form the mixture, wherein a concentration of the vanilloid receptor agonist is between 10 nanomolar (nM) and 10 mmolar, and wherein the glycosaminoglycan or proteoglycan constitutes 0.5% to 10% of the mixture by weight.