Patent ID: 7541445

Claim:
A pentasaccharide building block for the preparation of synthetic heparinoids, said building block being of General Formula I, In which the configuration of the monosaccharidic units and the stereochemistry of the internal linkages is defined as D-gluco-alpha-1,4-D-glucurono-beta-1,4-D-Gluco-alpha-1,4-L-idurono-alpha-1,4-D-gluco, and the substituents are defined as; X 1 is selected from the group consisting of hydroxy, C 2 to C 10 ; alkoxy; aryloxy, thioalkyl, thioaryl, imidoyl, t butyldiphenylsilyloxy; a lipoaminoacid or other such group suitable for conjugation to delivery systems or solid supports; and the stereochemistry may be alpha or beta; or an alpha methoxy group; R H ,R H1 and R H2 are benzyl; R A is selected from the group consisting of an azido function, an NH-Dde, and NH-DTPM; R S1 , R S2 and R S5 are independently selected from the group consisting of alkylacyl and arylacyl; R S3 is selected from the group consisting of 4-methoxyphenyl and 4-methoxybenzyl; R S4 is selected from the group consisting of 4-methoxyphenyl and 4-methoxybenzyl; R E1 is methyl; R E2 is methyl; R B is selected from the group consisting of an azido function, an NH-Dde and an NH-DTPM group; R B1 is selected from the group consisting of an azido function, an NH-Dde and an NH-DTPM group; R P1 is benzyl; and R P2 is benzyl.