Patent ID: 8313896

Claim:
A method of treating a subject for a brain tumor comprising: administering to the subject a composition comprising mature dendritic cells produced by incubating a population of immature dendritic cells generated from a sample obtained from the subject or a closely matched donor, with: (i) a brain tumor cell of the subject, infected with an effective amount of oncolytic herpes simplex virus (oHSV) G207 or G47Δ; (ii) a composition derived from a brain tumor cell of the subject infected with an effective amount of oHSV G207 or G47Δ, wherein the composition is selected from the group consisting of supernatant, conditioned medium, eluate, and lysate; (iii) A brain tumor cell of the subject and an effective amount of oHSV G207 or G47Δ; or (iv) a composition derived from a brain tumor cell of the subject and an effective amount of oHSV G207 or G47Δ, wherein the composition is selected from the group consisting of supernatant, conditioned medium, eluate, and lysate; to thereby produce mature dendritic cells; to thereby treat the subject for the brain tumor.