Patent ID: 8466161

Claim:
A hydroxamate compound of the following formula I, an isomer, pharmaceutically acceptable salt or hydrate thereof, wherein n is an integer of 2, 3 or 4; Ar is a phenyl, pyridine or pyrimidine group which is unsubstituted or substituted with one or more substituents selected from the group consisting of C 1-6 alkyl, amino, nitro, thiomethyl, hydroxyl, nitrile, carboxyl, C 1-4 alkyloxy, aryl C 1-4 alkyloxy, halogen, trifluoromethyl, —O—CF 3 , phenyl and phenoxy groups; R 1 is an indole, indazole or benzimidazole group, which is unsubstituted or substituted with one or more substituents selected from the groups consisting of C 1-6 alkyl, formyl, amino, nitro, thiomethyl, hydroxyl, C 1-6 alkoxy, nitrile, carboxyl, halogen, trifluoromethyl, —O—CF 3 , —C(O)—R 5 , —S(O 2 )—R 5 and and R 2 is hydrogen, hydroxy C 1-6 alkyl, C 1-8 alkyl, —C(O)—R 5 , —C(O)NH—R 5 , —S(O 2 )—R 5 , —C(S)—R 5 or —C(O 2 )—R 5 , in which R 5 is naphthyl, C 1-8 alkyl or C 1-4 alkyloxy group, Z 1 and Z 2 are each independently hydrogen, C 1-6 alkyl, amino, —O—C 1-4 alkyl, —S(O 2 )C 1-4 alkyl, —C(O)C 1-4 alkyl, —S—C 1-4 alkyl, halogen, trifluoromethyl, —O—CF 3 , phenyl, —O-phenyl, —O—C 1-4 alkylaryl, V and W are each independently hydrogen or C 1-6 alkyl, Each s is independently an integer of 0, 1, 2, 3, 4 or 5, and Each m is independently an integer of 0, 1, 2 or 3.