Patent ID: 8642628

Claim:
The compound of formula I or pharmaceutically acceptable salts thereof: wherein R 1 is selected from the group consisting of R 5 and R 6 ; R 1 ′ is R 5 when R 1 is R 6 , and R 6 when R 1 is R 5 ; R 2 is selected from the group consisting of hydrogen, halogen, hydroxyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, cyano, nitro, trifluoromethyl, carbamoyl, C 1 -C 6 alkylcarbamoyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 alkoxyl, and C 3 -C 6 cycloalkoxyl; R 3 is selected from the group consisting of halogen, hydroxyl, carbamoyl, substituted carbamoyl, C 1 -C 6 alkylcarbamoyl, sulfamoyl, C 1 -C 6 alkylsulfamoyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, cyano, nitro, amino, CF 3 , carboxyl, ureido, sulfamoylamino, 2-amino-2-oxoethyl, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, arylamino, heteroarylamino, C 1 -C 6 alkoxyl, C 3 -C 6 cycloalkoxyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 4 is selected from the group consisting of hydrogen, hydroxyl, halogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, cyano, nitro, carbamoyl, C 1 -C 6 alkylcarbamoyl, sulfamoyl, C 1 -C 6 alkyl sulfamoyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 alkoxyl, and C 3 -C 6 cycloalkoxyl; R 5 is selected from the group consisting of aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 6 is selected from the group consisting of —CR 7 R 8 CR 9 R 10 (CR 11 R 12 ) n R 13 and R 7 , R 8 , R 9 , R 10 , R 11 , and R 12 are each independently selected from the group consisting of hydrogen, hydroxyl, halogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl and wherein R 9 and R 10 together form a C 3 -C 6 cycloalkyl; R 13 is selected from the group consisting of COOH and NH 2 SO 2 CF 3 ; R 14 is selected from the group consisting of OH, COOH, and SO 2 NH 2 ; R 15 and R 16 are independently selected from the group consisting of hydrogen, hydroxyl, carboxyl, NO 2 , and halogen; n is 0 or 1; and X and Y are independently selected from the group consisting of C and N.