Patent ID: 7619091

Claim:
A compound of the formula or pharmaceutically acceptable salts, thereof in which R 1 is H; R 2 is; optionally substituted phenyl; optionally substituted naphthyl; optionally substituted tetrahydronaphthyl; optionally substituted biphenyl; optionally substituted heterocyclyl; COR 6 ; CSR 6 ; CN; (CH 2 )NR 9 R 10 ; HCNOR 9 ; HCNNR 9 R 10 ; OR 11 ; SR 11 ; NR 11 R 12 or SO 2 NR 13 R 14 ; R 6 is H, C 1-6 alkyl, optionally substituted C 2-6 alkenyl, hydroxy, optionally substituted aryl, optionally substituted heterocyclyl, SR 7 or NR 7 R 8 ; R 7 and R 8 are either the same or different and selected from H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted aryl and optionally substituted heterocyclyl; R 9 is H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R 10 is hydrogen, methyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, neopentyl, hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, optionally substituted C 2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R 11 is H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl or together with R 12 form optionally substituted heterocyclyl; R 12 is optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl or together with R 11 form optionally substituted heterocyclyl; R 3 , R and R′ are either the same or different and selected from H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 1-6 alkoxy, optionally substituted acyl, hydroxy, optionally substituted amino, optionally substituted thio, optionally substituted sulphonyl, optionally substituted sulphinyl, optionally substituted sulphonylamino, halo, SO 3 H, amine, CN, CF 3 , optionally substituted aryl and optionally substituted heterocyclyl; and R 4 and R 5 are chloro, wherein the optional substituent is C 1-6 alkyl, CF 3 , fluorine, chlorine, iodine, cyano, C 1-6 alkoxy, 5 or 6-membered aryl, heteroaryl, amino or C 1-6 alkylamino.