Patent ID: 8632803

Claim:
A pharmaceutical composition, comprising a pharmaceutically acceptable carrier, diluent, excipient or auxiliary agent and, as active ingredient, either fibrils or insoluble aggregates of insulin, which fibrils or insoluble aggregates are capable of dissociating and releasing soluble monomers of insulin in therapeutically active form, where said fibrils or insoluble aggregates are (a) encapsulated in a lipidated glycosaminoglycan particle, which comprises the reaction product of at least one glycosaminoglycan with at least one lipid having a primary amino group, (b) coated with a multi-layer of at least two lipids and conjugates of one of said at least two lipids and at least one glycosaminoglycan, or (c) present as unencapsulated and uncoated fibrils or insoluble aggregates.