Patent ID: 7407976

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein X is S; R 1 isphenyl, wherein R 1 is optionally substituted with x independent occurrences of —QR x ; wherein x is 0-5; wherein Q is a bond or is a C 1 -C 6 alkylidene chain wherein up to two methylene units of Q are optionally and independently replaced by —CO—, —CO 2 —, —COCO—, —CONR—, —OCONR—, —NRNR—, —NRNRCO—, —NRCO—, —NRCO 2 —, —NRCONR—, —SO—, —SO 2 —, —NRSO 2 —, —SO 2 NR—, —NRSO 2 NR—, —O—, —S—; or —NR—; and each occurrence of R X is independently R′, halogen, NO 2 , or CN, or —QR x is ═O, ═S, or ═NR′; Z is —CH 2 ; each occurrence of R is independently hydrogen or C 1 -C 6 aliphatic group; and each occurrence of R′ is independently hydrogen or C1-C6 alkyl; R 2 is halogen, —CN, —NO 2 , or —T q R; R 3 is U m R′ and R 4 is V p Cy 1 , wherein m is 0; p is 1; q is 0 or 1, and U, and T are each independently C 1 -C 4 alkylidene chain, wherein up to two methylene units of the chain are optionally and independently replaced by —CO—, —CO 2 —, —COCO—, —CONR—, —OCONR—, —NRNR—, —NRNRCO—, —NRCO—, —NRCO 2 —, —NRCONR—, —SO—, —SO 2 —, —NRSO 2 —, —SO 2 NR—, —NRSO 2 NR—, —O—, —S—; or —NR—; V is —CH 2 C(R 6 ) 2 — or —C(R 6 ) 2 —; R 6 is independently hydrogen, methyl, or two occurrences of R 6 on the same carbon are taken together to form a 3-6 membered ring selected from cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl; Cy 1 is a 3-8 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein Cy 1 is optionally substituted at one or more carbon or nitrogen atoms with y independent occurrences of —WR W ; wherein y is 0-5; wherein W is a bond or is a C 1 -C 6 alkylidene chain wherein up to two methylene units of W are optionally and independently replaced by —CO—, —CO 2 —, —COCO—, —CONR—, —OCONR—, —NRNR—, —NRNRCO—, —NRCO—, —NRCO 2 —, —NRCONR—, —SO—, —SO 2 —, —NRSO 2 —, —SO 2 NR—, —NRSO 2 NR—, —O—, —S—; or —NR—; and each occurrence of R W is independently R′, halogen, NO 2 , or CN, or —WRW is ═O, ═S, or ═NR′; or provided that: a) when X is S; and R 2 is formyl, 4,5-dihydro-2-oxazolyl, —COOR′, or COSR′; then: i) when Z is —CH 2 —, R 1 is not phenyl optionally substituted with C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 haloalkylthio, halogen, cyano, or nitro; b) when X is S, R 2 is Sme or Me, Z is CH 2 and R 1 is unsubstituted phenyl, i) when R 3 is hydrogen, then R 4 is not unsubstituted benzyl; and ii) when R 3 is ethyl, then R 4 is not unsubstituted phenyl.