Patent ID: 7879797

Claim:
A compound of formula III: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from the group consisting of CO 2 R 10 and CONHSO 2 R 6 ; R 2 is selected from the group consisting of C 1 -C 4 alkyl and C 2 -C 4 alkenyl; R 3 is selected from the group consisting of C 1 -C 8 alkyl and C 3 -C 8 cycloalkyl wherein each alkyl or cycloalkyl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, OR 10 , SR 10 , N(R 10 ) 2 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, NO 2 , CN, CF 3 , SO 2 (C 1 -C 6 alkyl), NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , NHCOOR 6 , NHCOR 6 , NHCONHR 6 , CO 2 R 10 , and CON(R 10 ) 2 ; R 4 is selected from the group consisting of H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, and aryl(C 1 -C 8 )alkyl; wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, OR 10 , SR 10 , N(R 10 ) 2 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, NO 2 , CN, CF 3 , SO 2 (C 1 -C 6 alkyl), NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , NHCOOR 6 , NHCOR 6 , NHCONHR 6 , CO 2 R 10 , and CON(R 10 ) 2 ; R 5 is selected from the group consisting of CO 2 R 4 , aryl, and heteroaryl, wherein said aryl or heteroaryl is optionally substituted with 1 to 4 substituents selected from the group consisting of halo, OR 10 , SR 10 , N(R 7 ) 2 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkoxy, NO 2 , CN, CF 3 , SO 2 (C 1 -C 6 alkyl), NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , NHCOOR 6 , NHCOR 6 , NHCONHR 6 , CO 2 R 10 , and CON(R 10 ) 2 ; each R 6 is independently selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, and heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents or P(O)R 11 R 12 , and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from the group consisting of N, O and S, attached through a ring carbon or nitrogen; W is selected from the group consisting of H and C 1 -C 6 alkoxyl; X is O; Y is selected from the group consisting of C═O and SO 2 ; Z is selected from the group consisting of O, CH 2 and N(R 4 ), and wherein R 4 is H or methyl; M is selected from the group consisting of unsubstituted C 1 -C 5 alkylene and unsubstituted C 2 -C 5 alkenylene; L is a direct bond; each R 7 is independently selected from the group consisting of H, C 1 -C 6 alkyl and C 3 -C 6 cycloalkyl; and each R 10 is independently selected from the group consisting of H and C 1 -C 6 alkyl.