Patent ID: 7250417

Claim:
A compound of the formula I: wherein: X is N; each Y is N; R 1 and R 2 are independently selected from the group consisting of hydrogen, halogen, —CN, —COR 7 , —COOR 7 , —CONR 7 R 8 , —CF 3 , lower alkyl, cycloalkyl, heteroalicyclic, alkenyl and alkynyl; R 3 is a substituent selected from the group consisting of F, Cl, —OH, —OR 7 , —COR 9 , —NR 7 R 8 , —CN, —SO 2 R 7 , —S(O)R 7 , SO 2 NR 7 R 8 , —CF 3 , and lower alkyl; wherein if p is greater than 1, then each R 3 is independently F, Cl, —OH, —OR 7 , —COR 9 , —NR 7 R 8 , —CN, —SO 2 R 7 , —S(O)R 7 , SO 2 NR 7 R 8 , —CF 3 , or lower alkyl; R 4 is selected from the group consisting of substituted or unsubstituted heteroaryl, and substituted aryl; R 5 is selected from the group consisting of hydrogen, halogen, —OH, —COR 7 , —COOR 7 , —CONR 7 R 8 , —NR 7 R 8 , —CN, —NO 2 , —S(O) 2 R 7 , —S(O)R 7 , —SO 2 NR 6 R 7 , —CF 3 , —NR 6 C(O)NR 7 R 8 , —NR 6 C(O)R 7 , —NR 6 SO 2 R 7 substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalicyclic, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; R 6 , R 7 and R 8 are independently selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, heteroalicyclic, alkenyl, alkynyl, aryl, heteroaryl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl and heteroaryl; or R 7 and R 8 or R 6 and R 7 , together with the atom to which they are attached, form a heteroalicyclic ring optionally substituted with a group selected from the group consisting of alkyl, —OH, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylamino, or dialkylamino; R 9 is a substituent selected from the group consisting of H, lower alkyl, cycloalkyl, heteroalicyclic, alkenyl, alkynyl, aryl, dialkylaminoalkyl, heteroaryl and alkylaminoalkyl; n is 1, 2 or 3, it being understood that when n is greater than 1, the R 1 and R 2 groups on each carbon atom may be the same as or different from the R 1 and R 2 groups on any adjacent carbon atom; and p is 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof.