Patent ID: 7449477

Claim:
A compound of the formula (I): wherein R 1 is hydrogen, halogen, hydroxy, amino, —CHF 2 , —CF 3 , or —NHSO 2 CH 3 ; R 2 , R 3 , and R 4 are each independently selected from the group consisting of: hydrogen; halogen; —(C 1 -C 4 )alkyl; —CF 3 ; amino; nitro; —(CH 2 ) p OR 10 ; —(CH 2 ) n CN; —C(O)NR 11 R 12 ; —C(O)OR 16 ; —NHC(O)R 13 ; —O(CH 2 ) o Y; —SCH 3 ; —SO 2 R 14 ; N-morpholino; N-piperazine or N-piperazine substituted with (C 1 -C 4 )alkyl; N-pyrrolidine or N-pyrrolidine substituted with —(CH 2 ) p OH; N-1,1-dioxothiomorpho line; N-[1,4]-diazepinyl; phenyl or phenyl substituted with —CF 3 , nitro, amino, halogen, hydroxy, (C 1 -C 4 ) alkyl, (C 1 -C 4 )alkoxy or —NHSO 2 CH 3 ; and piperidine or piperidine substituted on the nitrogen with —C(O)(C 1 -C 4 ) alkyl; or R 2 and R 3 may, together with the phenyl ring to which they are attached, form a naphthaline (benzo-fused ring) of the structure: R 5 , R 6 and R 8 are hydrogen; R 7 and R 9 are each independently hydrogen or hydroxy; R 10 is hydrogen, (C 1 -C 4 )alkyl, —(CF 2 ) t CHF 2 , —(CH 2 ) q NR 17 R 18 , —(CH 2 ) q O(C 1 -C 4 alkyl), pyrrolidine, or phenyl; which pyrrolidine may be optionally substituted on the nitrogen with C 1 -C 4 alkyl R 11 and R 12 are each independently hydrogen or (C 1 -C 4 )alkyl; R 13 is (C 1 -C 4 )alkyl, cyclopropyl or —(CH 2 )—OR 19 ; R 14 is (C 1 -C 4 )alkyl, —NR 20 R 21 , N-pyrrolidine, phenyl, or -CF 3 ; R 16 , R 17 , R 18 , R 19 , R 20 , and R 21 are each independently hydrogen or C 1 -C 4 alkyl; m is 0, 1, 2, or 3; n is 0 or 1; o is 1, 2 or 3; p is 0, 1 or 2; q is 1, 2, or 3; t is 0 or 1; Y is morpholine, pyrrolidine, or pyrrolidine substituted on the nitrogen by (C 1 -C 4 )alkyl; or a pharmaceutically acceptable salt thereof.