Patent ID: 6852761

Claim:
A compound of the Formula: or a pharmaceutically acceptable salt thereof, wherein J is hydroxy or fluoro; B is a C3-C7 cycloalkyl, pyrrolidinyl, or piperidinyl wherein each ring carbon is optionally substituted with R 33 , R 33 is selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amine, alkexyamino, alkylamino, alkyithie, amidesulfenyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, and cyano; A is a bond or (CH 2 ) pa where pa is 1-3; R 1 and X 0 are independently hydrido, or halo; R 2 is Z 0 —Q; Z 0 is a bond; Q is phenyl, thinyl, or pyridyl, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10 and R 12 , respectively, is optionally substituted by R 11 ; R 9 , R 11 , and R 13 are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano; R 10 and R 12 are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano; and Y 0 is 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, or 3-fluoro-4-amidinobenzyl.