Patent ID: 8288371

Claim:
A compound of formula I: wherein X is an sp 2 -hybridized carbon atom; X 7 is selected from sp 2 -hybridized C and N; Q, including X and X 7 , is a 5- or 6-membered unsaturated, optionally substituted ring and is selected from carbocycle and heterocycle; R 1a and R 1b are independently selected from H and CH 3 or R 1a and R 1b taken together with the carbon atom to which they are attached may form a (C 3 -C 7 )cycloalkyl group, with the proviso that both R 1a and R 1b cannot be CH 3 ; R 2 is selected from H, methyl, ethyl, methoxy, ethoxy, cyano and halo; R 4 is selected from H, methyl, ethyl, methoxy, ethoxy, cyano and halo; Y is selected from â€”C(â•O)â€”, â€”Oâ€”, and â€”CR 5 R 6 â€”, wherein R 5 is selected from H, methyl, ethyl, methoxy, ethoxy, â€”OH, F, â€”OC(â•O)CH 3 and â€”OC(â•O)CH 2 CH 3 ; and R 6 is selected from H, methyl and ethyl; W is â€”CHR 8 â€” or Yâ€”W taken together represents â€”CR 5 â•CR 8 â€”; R 8 is chosen from H, methyl and ethyl, or R 8 taken together with R 5 forms a carbocycle; X 8 is selected from CH and N; Z is wherein R is selected from the group consisting of an optionally substituted alkyl group, an optionally substituted carbocycle and an optionally substituted heterocycle, wherein said alkyl group, carbocycle or heterocycle is attached to the remainder of Z through a carbon atom; R 11 is selected from H, methyl and ethyl; R 12 and R 13 are independently selected in each occurrence from H, methyl and ethyl or R 12 and R 13 taken together with the carbon atom to which they are attached may form a 3 to 7-membered cyclic group; p is zero, one or two; and q is one or two.