Patent ID: 7790707

Claim:
A compound having the formula: or pharmaceutically acceptable salts thereof; wherein, p and q are independently 0, 1, 2, 3 or 4; Z is O, NR 2 , S, S(O), S(O) 2 , S(O) 2 NR 2 , (CR 3 R 4 ) n , C═O, C═S, or C═N—R 2 ; n is 1, 2, 3 or 4; R 1 is aryl or heteroaryl; R 2 is hydrogen, hydroxyl, S(O) 2 , C═O, C═S, C═NH, C 1-6 alkyl, C 1-5 alkoxy, C 1-5 alkylthio, halo-substituted C 1-6 alkyl, halo-substituted C 1-5 alkoxy, aryl, or heteroaryl; R 3 and R 4 are independently hydrogen, halo, hydroxyl, cyano, C 1-6 alkyl, C 1-5 alkoxy, C 1-5 alkylthio, halo-substituted C 1-6 alkyl, halo-substituted C 1-5 alkoxy, aryl, or heteroaryl; or R 3 and R 4 , taken together, may form C═O; X is WC(O)OR 5a , WP(O)R 5b R 5c , WS(O) 2 OH, WS(O) 2 NH 2 , WCONHSO 3 H or 1H-tetrazol-5-yl; W is a direct bond, O, or C 1-4 alkylene optionally substituted with one or more of halo, hydroxyl, cyano, amino, alkylamino, aryl amino, heteroaryl amino group, C 1-4 alkoxy, or CO 2 H; R 5a is hydrogen or C 1-4 alkyl; R 5b and R 5c are independently hydrogen, hydroxyl, C 1-4 alkyl, or halo substituted C 1-4 alkyl; Y is Q is a direct bond, C═O, C═S, SO 2 , C(O)NR 9 , or (CR 9 R 10 ) m ; m is 0 or 1; R 6 and R 7 are independently hydrogen, halo, hydroxyl, cyano, C 1-6 alkyl, C 1-5 alkylthio, C 1-5 alkoxy, halo-substituted C 1-6 alkyl or halo-substituted C 1-5 alkoxy; or R 6 and R 7 may be joined together with the atoms to which they are attached to form a 4- to 7-membered ring, or R 6 is an alkylene group with the omega end of said alkylene group attached to ring A; R 8 is hydrogen, halogen, hydroxyl, amino, cyano, C 1-6 alkyl, C 1-5 alkylthio, C 1-5 alkoxy, halo-substituted C 1-6 alkyl, or halo-substituted C 1-5 alkoxy; R 9 and R 10 are independently hydrogen, halo, hydroxyl, cyano, C 1-6 alkyl, C 1-5 alkoxy, C 1-5 alkylthio, halo-substituted C 1-6 alkyl, halo-substituted C 1-5 alkoxy, or —CO 2 R 5a ; A is aryl or heteroaryl, either of which may optionally be substituted with 1, 2, or 3 substituents selected from the group consisting of halo, hydroxyl, cyano, C 1-6 alkyl, C 1-5 alkylthio, C 1-5 alkoxy, halo-substituted C 1-6 alkyl, and halo-substituted C 1-5 alkoxy; B has the formula: in which, the asterisks indicate the point of attachment in formula I; r is 1; U is CH 2 , C(H)CH 3 , C(CH 3 ) 2 , C(H)(CF 3 ) or C(CF 3 ) 2 ; and V is C(═O) or C(═S).