Patent ID: 8772502

Claim:
A compound of structural Formula (1): and pharmaceutically acceptable salts thereof, wherein R 1 is selected from the group consisting of hydrogen and Q-C(═O)—, any of which may be optionally substituted; R 2 to R 5 are independently selected from the group consisting of hydrogen, D, hydroxy, F, Cl, Br, CN, NO 2 , (C 1 -C 6 )-alkyl, (C 3 -C 8 )-cycloalkyl, (C 1 -C 6 )-alkoxy, carboxy, (C 1 -C 6 )-alkoxycarbonyl, amino, (C 1 -C 6 )-acylamino, amido, (C 1 -C 6 )-alkylamido, (C 1 -C 6 )-dialkylamido, (C 1 -C 6 )-alkylsulfonylamino, (C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-perhaloalkyl, (C 1 -C 6 )-perhaloalkoxy, (C 1 -C 6 )-alkyithio, (C 1 -C 6 )-alkylthioalkyl, (C 1 -C 6 )-alkylsulfonyl, (C 3 -C 8 )-cycloalkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, heteroarylsulfonyl, heteroarylalkylsulfonyl, (C 1 -C 6 )-alkylsulfonamido, N,N′-(C 1 -C 6 )-dialkylsulfonamido, aryl, aryloxy, arylthio, arylalkylthio, heteroaryl, heteroaryloxy, heteroarylalkoxy, heteroarylthio, heteroarylalkylthio, heterocycloalkyl, heterocycloalkoxy, and Q-C(═O)— , any of which may be optionally substituted; or any two contiguous R 1 , R 2 or R 3 moieties may be combined together with the atoms to which they are attached and joined to form an optionally substituted 5-to 8-membered heterocycloalkyl ring; wherein when one of R 6 or R 7 is hydrogen, the other is independently selected from the group consisting of (C 1 -C 6 )-alkylsulfinyl, (C 1 -C 6 )alkylsulfinyalkyl, (C 2 -C 6 )-alkenylsulfinyl, (C 2 -C 6 )-alkynylsulfinyl, (C 3 -C 8 )-cycloalkylsulfinyl, (C 5 -C 8 )-cycloalkenylsulfinyl, arylsulfinyl, arylalkylsulfinyl, arylalkenylsulfinyl, heteroarylsulfinyl, heteroarylalkylsulfinyl, heteroarylalkenylsulfinyl, and heterocycloalkylsulfinyl, any of which may be optionally substituted; or the R 6 and R 7 moieties may be combined together with the atoms to which they are attached and joined to form an optionally substituted 5-to 8-membered ring that incorporates a sulfinyl (—S[O]—) moiety; and wherein Q is R 8 , OR 8 , NHR 8 , or NR 8 R 9 ; R 8 and R 9 are independently selected from the group consisting of hydrogen, (C 1 -C 12 )-alkyl, (C2-C 12 )-alkenyl, (C 2 -C 12 )-alkynyl, (C 3 -C 8 )-cycloalkyl, aryl, arylalkyl, arylalkenyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, and heteroarylalkenyl, any of which may be optionally substituted; or R 8 and R 9 , together with the atoms to which they are attached, may be joined to form an optionally substituted 5-to 8-membered heterocycloalkyl ring; any of which may be optionally substituted.