Patent ID: 7601702

Claim:
A method of treatment of plasmodium infections in mammals, including man, comprising administering to an individual in need thereof an effective amount of formula I where A is O, S or CH 2 ; B is O, S or CHR 3 ; R 1 is H, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl or a 5 or 6 membered, saturated or unsaturated ring containing 0 to 3 heteroatoms selected from N, O and S, the alkyl, alkenyl, alkynyl or ring being independently optionally substituted with R 4 ; R 2 is H, F; R 3 is H, F, OH, NH 2 or a pharmaceutically acceptable ester, amide or ether thereof; or R 2 and R 3 together form a chemical bond; D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C≡C—, —NR 5 —; R 4 is independently selected from hydrogen, halo, cyano, amino, nitro, carboxy, carbamoyl, hydroxy, oxo, C 1 -C 5 alkyl, C 1 -C 5 haloalkyl, C 1 -C 5 alkyloxy, C 1 -C 5 alkanoyl, C 1 -C 5 alkanoyloxy, C 1 -C 5 alkylthio, —N(C 0 -C 3 -alkyl) 2 , hydroxymethyl, aminomethyl, carboxymethyl; —SO n N(C 0 -C 3 -alkyl), —SO n C 1 -C 5 -alkyl, where n is 1 or 2; R 5 is H, C 1 -C 4 alkyl, C 1 -C 4 alkanoyl; E is Si or C; R 6 , R 7 and R 8 are independently selected from C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or a stable monocyclic, bicyclic or tricyclic ring system which is saturated or unsaturated in which each ring has 0 to 3 heteroatoms selected from N, O and S; R 6 , R 7 and R 8 are independently optionally substituted with R 4 ; with the proviso that if R 3 is H, OH, F, NH 2 or a bond, then at least one of R 6 , R 7 and/or R 8 comprises an unsaturated ring; or a pharmaceutically acceptable salts thereof.