Patent ID: 7488590

Claim:
A process for preparing a pharmacologically active compound, which comprises: (a) selecting tram a peptide phage display library at least one nucleic acid sequence encoding a peptide that modulates the activity of AGP-3, wherein “peptide” refers to molecules of 2 to 40 amino acids; (b) preparing a gene construct that encodes at least one said selected peptide and an Fc domain of the formula (X 1 ) a -F 1 -(X 2 ) b and multimers thereof, wherein: F 1 is an Fc domain; X 1 and X 2 are each independently selected from -(L 1 ) c -P 1 , -(L 1 ) c -P 1 -(L 2 ) d -P 2 , -(L 1 ) c -P 1 (L 2 ) d -P 2 -(L 3 ) a -P 3 , and (L 1 ) c -P 1 -(L 2 ) d -P 2 -(L 3 ) e -P 3 -(L 4 ) f -P 4 ; P 1 , P 2 , P 3 , and P 4 are each independently encoded by the selected peptide sequences; L 1 , L 2 , L 3 , and L 4 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1 (c) expressing the pharmacologically active compound comprising the Fc-peptide fusion protein from said gene construct; and (d) Isolating said expressed protein, wherein said isolated protein modulates the activity of AGP-3.