Patent ID: 8481548

Claim:
A compound of formula I wherein R 1 is halogen or cyano; R 2 is lower alkyl; R 3 is pyridinyl, pyrimidinyl, or pyrazinyl each of which is optionally substituted by one, two or three substituted, selected from the group consisting of halogen, lower alkyl, cycloalkyl, lower alkyl-halogen, cyano, lower alkoxy, and NR′R″, R is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl and CH 2 -cycloalkyl; R′ and R″ are each independently selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, CH 2 -cycloalkyl, and (CH 2 ) n OR, wherein n is 1 or 2; and R 4 is selected from the group consisting of hydrogen, C(O)H, and CH 2 R 5 wherein R 5 is selected from the group consisting of hydrogen, OH, C 1 - C 6 -alkyl and C 3 -C 12 -cycloalkyl; or a pharmaceutically acceptable at thereof.