Patent ID: 8008263

Claim:
A compound of the Formula I: and pharmaceutically acceptable salts and stereoisomers thereof; wherein X is absent or selected from NR 5a or oxygen; i and k are independently selected integers selected from the group consisting of 0, 1, 2, 3 and 4; j is an integer selected from the group consisting of 1, 2, 3 and 4, wherein the sum of i+j+k is less than or equal to 5 and greater than or equal to 2 when X is absent and the sum of i+j+k is less than or equal to 4 and greater than or equal to 1 when X is oxygen; p is 0, 1, 2 or 3; E is OH, NH 2 , N(H)C 1-4 alkyl, N(H)C 3-6 cycloalkyl, —C(O)NH— or —N(H)S(O) 2 —; R 1 is absent, hydrogen, C 1-4 alkyl or C 3-6 cycloalkyl; R 2 is C 1-4 alkyl, haloC 1-4 alkyl, or C 3-6 cycloalkylC 0-2 alkyl; R 2a is hydrogen, C 1-4 alkyl, haloC 1-4 alkyl, or C 3-6 cycloalkylC 0-2 alkyl; or R 2 and R 2a , taken in combination form a three membered saturated ring, which ring is substituted with zero, one or two substituents independently selected from C 1-4 alkyl and C 2-4 alkenyl; R 3 and R 4 are independently selected from the group consisting of C 1-6 alkyl, C 4-7 cycloalkyl and C 4-7 cycloalkyl substituted with a C 1-4 alkyl residue; R 5 represents zero to three residues on each independently selected at each occurrence from the group consisting of halogen, hydroxy, amino, C 1-4 alkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, mono- and di-C 1-4 alkylamino, hydroxyC 1-4 alkyl, and C 1-4 alkoxyC 1-4 alkyl; R 5a is independently selected at each occurrence from the group consisting of hydrogen, C 1-4 alkyl, haloC 1-4 alkyl, C 3-6 cycloalkyl, hydroxyC 1-4 alkyl, and C 1-4 alkoxyC 1-4 alkyl; and R 6 and R 7 are independently selected from hydrogen and C 1-4 alkyl.