Patent ID: 8530653

Claim:
An enzyme inhibiting compound according to the structure of any of Formula (19) through Formula (22) wherein: R 4 , R 5 , R 6 , R 7 , and R 8 are independently selected from the group consisting of H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, —C(O)-alkyl, —C(O)-alkenyl, and —C(O)-alkynyl; X is a group selected from amino, amide, oxygen, or alkylene, wherein the alkylene optionally includes one or more heteroatoms, and wherein one or more of any carbon or nitrogen atoms is optionally substituted with one or more substituents R 9 ; R 9 is selected from the group consisting of H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, O, optionally substituted acyl, —C(O)-alkyl, —C(O)-alkenyl, —C(O)-alkynyl, optionally substituted alkoxy, hydroxyl, and halo; L is optionally aromatic, and one or more ring carbons are optionally replaced with a heteroatom selected from N, O, or S; each Z independently is one or more substituents and is selected from the group consisting of H, halo, optionally substituted alkyl, optionally substituted, hydroxyl, carbonyl, CF 3 , optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, alkaryl, arylalkyl, optionally substituted heteroaryl, optionally substituted heterocycle, amino, alkylamino, dialkylamino, carboxylic acid, carboxylic ester, carboxamide, nitro, cyano, amide, imide, azide, alkylcarbonyl, optionally substituted acyl, sulfonyl, alkylsulfonyl, sulfinyl, alkylsulfinyl, sulfenyl, alkylsulfenyl, and trialkylammonium; and pharmaceutically acceptable esters, amides, salts, solvates, prodrugs, and enantiomers thereof.