Patent ID: 8445476

Claim:
A compound having the following structure (II): or a stereoisomer, pharmaceutically acceptable salt, ester, or prodrug thereof, wherein: R 1 is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxyalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl and —C(═O)R 1a , wherein: R 1a is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxyalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl; R 2 is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl; R 3 is selected from hydrogen, chloro, bromo, fluoro, iodo, cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —SO 2 R 3a , —SOR 3a , —SR 3a , —C(═O)R 3a , —C(═O)NR 3a R 3b , —NR 3a R 3b and —OR 3a , wherein: R 3a is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl and optionally substituted heteroaryl; and R 3b is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl and an amino acid, or R 3a and R 3b , together with the N atom to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl; and Ar 2 is optionally substituted monocyclic aryl or optionally substituted monocyclic heteroaryl, wherein Ar 2 is not substituted with optionally substituted aryl or optionally substituted heteroaryl.