Patent ID: 8163738

Claim:
A compound of the Formula and tautomers and pharmaceutically acceptable salts thereof, wherein: Z is H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, OR 6 or NR 6 R 7 , wherein said alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, F, Cl, Br, I, CN, OR 6 , NR 6 R 7 , C(═O)R 6 , C(═O)OR 6 , OC(═O)R 6 , C(═O)NR 6 R 7 , (C 1 -C 6 alkyl)amino, CH 3 OCH 2 O—, R 6 OC(═O)CH═CH 2 —, NR 6 SO 2 R 7 , SR 6 and SO 2 R 6 ; R 1 , R 2 , R 3 and R 4 are independently selected from H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl, wherein said alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, F, Cl, Br, I, CN, OR 6 , NR 6 R 7 , C(═O)R 6 , C(═O)OR 6 , OC(═O)R 6 , C(═O)NR 6 R 7 , (C 1 -C 6 alkyl)amino, CH 3 OCH 2 O—, R 6 OC(═O)CH═CH 2 —, NR 6 SO 2 R 7 , SR 6 and SO 2 R 6 , or R 1 and R 2 together with the atom to which they are attached form a saturated or partially unsaturated carbocyclic ring, wherein said carbocyclic ring is optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, F, Cl, Br, I, CN, OR 6 , NR 6 R 7 , C(═O)R 6 , C(═O)OR 6 , OC(═O)R 6 , C(═O)NR 6 R 7 , (C 1 -C 6 alkyl)amino, CH 3 OCH 2 O—, R 6 OC(═O)CH═CH 2 —, NR 6 SO 2 R 7 , SR 6 and SO 2 R 6 , or R 3 and R 4 together are oxo; each R 5 is independently selected from H, F, Cl, Br, I, OMe, CH 3 , CH 2 F, CHF 2 , CF 3 and CF 2 CF 3 ; R 6 and R 7 are independently selected from H or alkyl; and n is 0, 1, 2, 3 or 4.