Patent ID: 7932251

Claim:
A 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivative having the general Formula I wherein R1 is H or (C1-3)alkyl; R2 is H or (C1-3)alkyl; R3 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; R4 is H, halogen or CN; X is CH2, O or S; n is 1-5; Y is selected from OH, CN, (C1-3)alkylcarbonyl, NR5R6 and Z, wherein Z is a saturated 5-or-6-membered heterocyclic ring containing 1-3 heteroatoms selected from O, S and NR7, which ring may be substituted by OH, oxo, (C1-3)alkyl, hydroxy(C1-3)alkyl or (C1-3)alkoxy(C1-3)alkyl; or wherein Z is an aromatic 5- or 6-membered heterocyclic ring containing 1-3 heteroatoms selected from O, S and N, which ring may be substituted by OH, (C1-3)alkyl or hydroxy(C1-3)alkyl; R5 and R6 are independently H, (C3-8)cycloalkyl or (C1-6)alkyl, optionally substituted with halogen, OH, CF3, (C3-8)cycloalkyl, (C1-6)alkyloxy, CONR14R15, NR14R15, SO2R16, a 5- or 6-membered heteroaryl group containing 1-3 heteroatoms selected from O, S and N, or a 5-or-6-membered saturated heterocyclic group containing a heteroatom selected from O, S or NR8; or R5 and R6 together with the nitrogen to which they are bound form a 4-10 membered saturated heterocyclic ring, optionally further comprising 1-3 heteroatoms selected from O, S and NR9, the ring being optionally substituted with OH, oxo, (C1-4)alkyl, hydroxy(C1-3)alkyl, (C3-8) cycloalkyl, CONR10R11 or NR10R11; R7 is H, (C1-3)alkyl or hydroxy(C1-3)alkyl; R8 is H, (C1-3)alkyl or hydroxy(C1-3)alkyl; R9 is H, (C1-3)alkyl, (C3-7)cycloalkyl, hydroxy(C1-3)alkyl, (C1-3)alkoxy(C1-3)alkyl, (C1-6)alkylcarbonyl, (C1-6)alkyloxycarbonyl, CONR12R13, CH2CONR12R13 or a 5-or 6-membered heteroaryl group containing 1-3 heteroatoms selected from O, S and N; R10 and R11, are independently H or (C1-3)alkyl; R12 and R13 are independently H or (C1-3)alkyl; or R12 and R13 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; R14 and R15 are independently H or (C1-3)alkyl; or R14 and R15 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; R16 is (C1-3)alkyl; or a pharmaceutically acceptable salt thereof.