Patent ID: 8138193

Claim:
A compound according to formula I: wherein Z is CH; R 1 is H or C 1 -C 6 alkyl; R 2 is H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, or C 3 -C 7 cycloalkyl-C 1 -C 6 alkyl; R 8 is cycloalkyl and R 9 is aryl or heteroaryl; wherein each of said R 1 , R 2 , R 8 and R 9 that is not H is independently optionally substituted by at least one of fluoro, chloro, bromo, W being C 1 -C 6 alkyl, carboxy, hydroxyl, carbamoyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, cyano, amino, aryl, 3-7-membered heterocycloalkyl, aralkyl, and heteroaryl, wherein said W is optionally substituted by at least one of fluoro, chloro, and bromo, and wherein said amino is optionally substituted by C 1 -C 6 alkyl; alternatively, R 8 is optionally substituted with -L-R 8d ; wherein L is a single bond, alkylene, heteroalkylene, —O—, —N(R 8e )—, —CO—, —CO 2 , —SO—, —SO 2 —, —CON(R 8e )—, —SO 2 N(R 8e )—, —N(R 8e )CO—, —N(R 8e )SO 2 , —N(R 8e )CON(R 8e )—, or —N(R 8e )SO 2 N(R 8e )—; and R 8d is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, aryl, 3-7-membered heterocycloalkyl, heteroaryl, amino, aralkyl, C 1 -C 6 heteroarylalkyl or C 1 -C 6 aminoalkyl; and R 8e is H, C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; wherein each of said R 8d or R 8e that is not H is independently optionally substituted by at least one of fluoro, chloro, bromo, W being C 1 -C 6 alkyl, carboxy, hydroxyl, carbamoyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, cyano, and amino, wherein said W is optionally substituted by at least one of fluoro, chloro, and bromo, and wherein said amino is optionally substituted by C 1 -C 6 alkyl; or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof.