Patent ID: 8710083

Claim:
A method of inhibiting immune cell activation comprising administering to the cell a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein: Y 1 is a monocyclic optionally substituted aryl or a monocyclic optionally substituted heteroaryl, provided that Y 1 is not a substituted isoxazolyl or a substituted 1H-pyrrolyl; L 1 is a linker selected from the group consisting of —NHCH 2 —, —CH 2 NH—, —NR—C(O)—, —OC(O)—, —C(O)O—, —C(S)—, —NR—C(S)—, and —C(S)—NR—; one of X 1 or X 2 is CH or CZ and the other is N; each Z is independently selected from the group consisting of a lower alkyl, a lower haloalkyl, a halo, a lower alkoxy, a lower alkyl sulfanyl, —S(O) p -alkyl, —C(O)NRR, —(CH 2 ) k NRR, —(CH 2 ) k OR, —(CH 2 ) k SR, cyano, nitro, and lower haloalkoxy; R, for each occurrence is independently selected from —H or an alkyl; R 3 is H, an alkyl, a haloalkyl, a halo, a haloalkoxy, —OR 5 , —SR 5 , or —NR 6 R 7 ; R 4 is oxazol-2-yl, oxazol-5-yl, thiazol-2-yl, thiazol-5-yl, [1,3,4]oxadiazol-2-yl, pyridin-3-yl, or pyridin-2-yl; R 5 , for each occurrence, is independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; R 6 and R 7 , for each occurrence are, independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; or R 6 and R 7 taken together with the nitrogen to which they are attached are an optionally substituted heterocyclyl or optionally substituted heteroaryl; q, for each occurrence, is independently, an integer from 1 to 3; k is for each occurrence, is independently, an integer from 1 to 4; n is zero, 1 or 2; and p, for each occurrence, is independently 1 or 2.