Patent ID: 8410250

Claim:
An isolated anti-FGFR3 antagonist antibody, wherein the antibody comprises: (i) a light chain variable region comprising (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO:87, (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO:88, and (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO:89, and (ii) a heavy chain variable region comprising (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:84, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:85, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:86, wherein the antibody binds human FGFR3 with a Kd of 1×10 −8 M or stronger, and wherein the antibody inhibits dimerization of FGFR3 receptor with another unit of the receptor, whereby activation of the receptor is inhibited.