Patent ID: 7964624

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: each A is —CH 2 —; each B is —CH 2 —; each R 1 is wherein: U is a bond or —O—; V is an alkyl; T is —C(O)—; and R is an aliphatic, cycloaliphatic, heterocycloaliphatic, aryl, heteroaryl, alkoxy, or cycloalkoxy, and is optionally substituted with 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, cyano, amino, nitro, aliphatic, haloaliphatic, (aliphatic)oxy, (halo(aliphatic))oxy, (aliphatic(oxy(aryl)))oxy, aryl, heteroaryl, haloaryl, cycloaliphatic, or heterocycloaliphatic; each R 2 is —Z B R 5 , wherein each Z B is independently a bond or an optionally substituted aliphatic wherein up to four carbon units of Z B are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NR B —, —C(O)NR B NR B —, —C(O)O—, —C(O)C(O)—NR B —, —NR B C(O)O—, —NR B C(O)NR B —, —NR B NR B —, —S—, —SO—, —SO 2 —, —NR B —, —SO 2 NR B —, or —NR B SO 2 NR B —, provided that —SO—, —SO 2 —, or —SO 2 NR B — is not directly bound to the carbonyl in formula (I); each R 5 is independently R B , halo, —OH, —CN, —NO 2 , —NH 2 , alkoxy, or haloalkoxy; each R B is independently hydrogen, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted aryl; or an optionally substituted heteroaryl; or, R 1 and R 2 , together with the atoms to which they are attached, form an optionally substituted heterocycloaliphatic ring; each R 3 is an optionally substituted aliphatic, amino, sulfonyl, sulfanyl, sulfinyl, sulfonamide, sulfamide, sulfo, —O—R 3A , an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl; each R 3A is independently an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl; and each of Y and Y′ is H.