Patent ID: 7183075

Claim:
An isolated and purified nucleic acid molecule encoding a biologically active KCC3a potassium-chloride cotransporter polypeptide selected from the group consisting of: (a) a biologically active KCC3a polypeptide encoded by a nucleic acid sequence as set forth in SEQ ID NO 15; (b) a biologically active KCC3a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO: 16 encoded by a nucleic acid molecule comprising a nucleic acid sequence having 90% or greater sequence identity to SEQ ID NO 15; (c) a biologically active KCC3a polypeptide having an amino acid sequence as set forth in SEQ ID NO 16; and (d) a biologically active KCC3a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO: 16, wherein the biologically active KCC3a polypeptide has potassium-chloride cotransporter activity.