Patent ID: 7109316

Claim:
An OTNTP comprising the structure wherein R and R′ independently represent H, OH, OCH 3 , CH 3 , N 3 , SH, NCO, NCS, SCN NH 2 , F, Cl or NR″R′″, wherein R″ and R′″ independently represent H or a small chain C1–C5 alkyl; X represents O, S, CH 3 or BH 3 ; Base represents uracil, cytosine, thymine, adenine, guanine, hypoxanthine, 2-aminopurine, 2,6-diaminopurine, xanthene, deazaadenine, deazaguanine or an analog thereof; Linker represents a linear or branched alkynyl, alkenyl, alkyl, alkylaryl, aryl, or arylalkyl containing one or more heteroatoms selected from the groups consisting of N, O, S and P, and is attached to the base; N represents a ribose, deoxyribose, a natural or unnatural deoxyribonucleoside or a natural or unnatural ribonucleoside, wherein one or more of the N's is labeled with a fluorescent dye; n represents an integer from 10 to 100; and wherein each N is linked to at least one other N by phosphodiester, phosphorothioate, alkyl phosphonate, or other linkages.