Patent ID: 8142778

Claim:
A method for inducing or enhancing a memory immune response to an antigen in a human patient, which comprises administering to the patient who has developed a primary immune response to the antigen an anti-CTLA-4 antibody such that plasma concentration of the anti-CTLA-4 antibody is maintained above detectable levels for greater than four months, wherein the anti-CTLA-4 antibody comprises a heavy chain variable region that comprises CDR1, CDR2, and CDR3 domains; and a light chain variable region that comprises CDR1, CDR2, and CDR3 domains, wherein the heavy chain variable region CDR1 comprises amino acids having the sequence set forth in SEQ ID NO:3; the heavy chain variable region CDR2 comprises amino acids having the sequence set forth in SEQ ID NO:4; the heavy chain variable region CDR3 comprises amino acids having the sequence set forth in SEQ ID NO:5; the light chain variable region CDR1 comprises amino acids having the sequence set forth in SEQ ID NO:6; the light chain variable region CDR2 comprises amino acids having the sequence set forth in SEQ ID NO:7; and the light chain variable region CDR3 comprises amino acids having the sequence set forth in SEQ ID NO:8.