Patent ID: 8648110

Claim:
A method of treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of ischemia-reperfusion injury comprising administering a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of benzene, pyrrole, and indole; labels 1 and 2 mark the relevant positions on the A ring; the X atom is nitrogen or carbon; R is a substituting group on the A ring selected from: a group in the 3 (meta) position that is linear or branched C 1 -C 5 alkyl, linear or branched C 2 -C 5 -alkenyl, linear or branched C 2 -C 5 -alkynyl, substituted or not-substituted phenyl, linear or branched C 1 -C 5 hydroxyalkyl, C 2 -C 5 -acyl, substituted or not-substituted benzoyl; a group in the 4 (para) position that is C 1 -C 5 -alkyl, C 2 -C 5 -alkenyl, C 2 -C 5 -alkynyl group, C 3 -C 6 -cycloalkyl, C 1 -C 5 -acyloxy, substituted or not substituted benzoyloxy, C 1 -C 5 -acylamino, substituted or not-substituted benzoylamino, C 1 -C 5 -sulfonyloxy, substituted or not-substituted benzenesulfonyloxy, C 1 -C 5 -alkanesulfonylamino, substituted or not-substituted benzenesulfonylamino, C 1 -C 5 -alkanesulfonylmethyl, substituted or not-substituted benzenesulfonylmethyl, 2-furyl; 3-tetrahydrofuryl; 2-thiophenyl; 2-tetrahydrothiophenyl, C 1 -C 8 -alkanoyl, cycloalkanoyl or arylalkanoyl-C 1 -C 5 -alkylamino; Hy is selected from the group consisting of methyl, ethyl, chlorine, bromine, methoxy, trifluoromethyl; Y is NH; and R′ is selected from H, C 1 -C 5 -alkyl, C 3 -C 5 -cycloalkyl, C 2 -C 5 -alkenyl; an amino acid residue consisting of straight or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, phenylalkyl substituted with one or more carboxy (COOH) groups; an amino acid residue consisting of straight or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, phenylalkyl, bearing along the chain a heteroatom selected from oxygen and sulfur and with one or more carboxy (COOH) groups; a residue of formula —CH 2 —CH 2 —Z—(CH 2 —CH 2 O)nR″ wherein R″ is H or C 1 -C 5 -alkyl, n is an integer from 0 to 2 and Z is oxygen or sulfur; a residue of formula —(CH 2 )n-NRaRb wherein n is an integer from 0 to 5 and each Ra and Rb, which may be the same or different, are C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl or, alternatively, Ra and Rb, together with the nitrogen atom to which they are bound, form a heterocycle from 3 to 7 members of formula (II) wherein W represents a single bond, CH 2 , 0, S or N-Rc, wherein Rc is H, C 1 -C 6 -alkyl or C 1 -C 6 -alkylphenyl; a residue OR″ wherein R″ is H, methyl or carboxymethyl.