Patent ID: 7166595

Claim:
A compound having the structure: wherein: R 1 is chosen from optionally substituted phenyl-C 1 —C 4 -alkyl-, optionally substituted heteroaryl-C 1 —C 4 -alkyl-, and naphthalenylmethyl-; R 2 and R 2′ are independently chosen from hydrogen, optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, and optionally substituted heteroaralkyl-; or R 2 and R 2 ′ taken together form a 3- to 7-membered ring; R 4 is chosen from hydrogen; alkoxy; cyano; carboxamido; aminocarbonyl-; lower-alkyl-; lower-alkyl substituted with one or more of the following substituents: halo, lower-alkoxy, or hydroxy; phenyl-; or phenyl substituted with one or more of the following substituents: halo, lower-alkoxy, and hydroxy; R 5 is chosen from hydrogen; carboxamido, cyano; lower-alkyl; halo; benzyl-; naphthyl-; furyl-; thienyl-; indolyl-; phenyl-; and phenyl substituted with one or more of the following substituents: optionally substituted amino, dialkylamino, cyano, halo, optionally substituted lower-alkyl-, optionally substituted lower-alkoxy, optionally substituted lower-alkyl sulfanyl, hydroxy, and thio; R 3 is —N(R 6 )(COR 7 ); R 7 is chosen from hydrogen, optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, optionally substituted heteroaralkyl-, R 8 O- and R 14 -NH-; R 6 is chosen from hydrogen, optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, and optionally substituted heteroaralkyl-; R 8 is chosen from optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, and optionally substituted heteroaralkyl-, and R 14 is optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, or optionally substituted heteroaralkyl-, including single stereoisomers and mixtures of stereoisomers; or a pharmaceutically acceptable salt of a compound of Formula I; wherein “substituted” alkyl, aryl and heteroaryl refer respectively to alkyl, aryl and heteroaryl wherein one or more hydrogen atoms are replaced by a substituent independently chosen from optionally substituted alkyl, optionally substituted alkoxy, alkylenedioxy, optionally substituted amino, optionally substituted amidino, optionally substituted aryl, optionally substituted aralkyl, optional substituted aryloxy, optionally substituted aralkoxy, carboxy, carboalkoxy, carboxyalkyl, carboxamido, aminocarbonyl, benzyloxycarbonylamino, cyano, acyl, halogen, hydroxy, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heteroaryloxy, optionally substituted heteroaralkoxy, nitro, sulfanyl, sulfinyl, sulfonyl, and thio.