Patent ID: 7741318

Claim:
A compound represented by the structural formula I or a pharmaceutically acceptable salt thereof, wherein: A is alkylene, R 16 -arylene, R 16 -cycloalkylene or R 16 -heteroaryldiyl; X is —C(O)— or —S(O) 2 —; R 1 is alkyl or cycloalkyl; R 2 is hydrogen, halo or —CN; R 3 is hydrogen or alkyl; R 4 is hydrogen, alkyl, alkoxy, hydroxyalkyl, -alkyl-NR 14 R 15 , cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted by alkyl, R 8 -arylalkyl or R 8 -heteroarylalkyl; or R 3 and R 4 together with the nitrogen to which they are attached, form a 5-7 membered ring, said ring optionally comprising an additional heteroatom ring member selected from the group consisting of —O—, —S— and —N(R 17 )—, said ring being optionally substituted by alkyl, hydroxyalkyl, R 8 -arylalkyl, R 8 -heteroarylalkyl, —N(R 9 )—C(O)alkyl, —CO 2 -alkyl, —C(O)NR 10 R 11 or heterocycloalkyl; or R 3 and R 4 together with the nitrogen to which they are attached, form the group R 7 is alkyl, R 12 -phenyl, R 12 -heteroaryl, cycloalkyl, halo, morpholinyl, n is 1 or 2; R 8 is 1-3 substituents independently selected from the group consisting of hydrogen, alkyl, halo, alkoxy, —CO 2 H, —CO 2 -alkyl, —CF 3 , —CN, —CO 2 NR 14 R 15 , —SO 2 -alkyl, —SO 2 NR 14 R 15 and —NR 14 R 15 ; R 9 is hydrogen or alkyl; R 10 and R 11 are independently selected from the group consisting of alkyl and cycloalkyl; or R 10 and R 11 form a C 4 -C 5 alkylene chain and together with the nitrogen to which they are attached, form a 5- or 6-membered ring; R 12 is 1 to 3 substituents independently selected from the group consisting of hydrogen, alkyl, halo, alkoxy, —CO 2 H, —CO 2 -alkyl, —CF 3 , —CN, —CO 2 NR 14 R 15 , —SO 2 -alkyl, —SO 2 NR 14 R 15 and —NR 14 R 15 ; R 13 is H, OH, hydroxyalkyl or alkyl; R 14 and R 15 are independently selected form the group consisting of hydrogen, alkyl and cycloalkyl; R 16 is 1 to 3 substituents independently selected from the group consisting of hydrogen, alkyl, halo, OH and alkoxy; and R 17 is hydrogen, alkyl, cycloalkyl or R 8 -arylalkyl.