Patent ID: 7101874

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof wherein: Y is (a) —S(═O) n —, (b) —S(═NR 8 )—, or (c) —S(═NR 8 )(═O)—; Z is (a) —NHC(═O)R 1 , (b) —NHC(═S)R 1 , (c) —NH-het 1 , (d) —O-het 1 , (e) —S-het 1 , or (f) -het 2 R 1 is (a) —H, (b) —NH 2 , (c) —NHC 1-4 alkyl, (d) —C 1-4 alkyl, (e) —C 2-4 alkenyl, (f) —(CH 2 ) n C(═O)C 1-4 alkyl, (g) —OC 1-4 alkyl, (h) —SC 1-4 alkyl, or (i) —(CH 2 ) n C 3-6 cycloalkyl; R 2 and R 3 are independently (a) —H, (b) —Cl, (c) —F, (d) —CH 3 , (e) —NH 2 , or (f) —OH; R 4 is (a) H, (b) C 1-4 alkyl, (c) OC 1-4 alkyl, (d) SC 1-4 alkyl, or (e) NHC 1-4 alkyl; R 5 is (a) H, (b) C 1-4 alkyl, (c) OC 1-4 alkyl, (d) SC 1-4 alkyl, or (e) NHC 1-4 alkyl; R 6 is (a) —H, (b) —F, (c) —Cl, (d) —NH 2 , (e) —OH, (f) —CN, (g) —C 1-4 alkyl, (h) —OC 1-4 alkyl, (i) —Cl 1-4 alkyl-W—C 1-4 alkyl, (j) —NHC 1-4 alkyl, (k) —(CH 2 ) n C 3-6 cycloalkyl, (l) —C(═O)C 1-4 alkyl, (m) —OC(═O)C 1-4 alkyl, (n) —C(═O)OC 1-4 alkyl, (o) —S(O) n C 1-4 alkyl, or (p) —C(═O)NHC 1-4 alkyl; R 8 is (a) —H, (b) —C 1-4 alkyl, (c) —C(═O)C 1-4 alkyl, (d) —C(═O)NHC 1-4 alkyl, (e) —OC(═O)C 1-4 alkyl, (f) —C(═O)OC 1-4 alkyl, or (g) —S(O) n C 1-4 alkyl, or (h) —C 1-4 alkyl-W—C 1-4 alkyl; W is O or S; aryl is phenyl, biphenyl, or naphthyl, optionally substituted with halo, —C 1-4 alkyl, —OH, —OC 1-4 alkyl, —S(O) n C 1-4 alkyl, and —C 1-4 alkyl-NH 2 ; het 1 is a C-linked five-(5) or six-(6) membered heterocyclic ring having 1–4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen; het 2 is a N-linked five-(5) or six-6) membered heterocyclic ring having at least one nitrogen atom, and optionally having one oxygen or sulfur atom; at each occurrence n is independently 0, 1, or 2; and at each occurrence, alkyl, alkenyl, or cycloalkyl is optionally substituted with one, two, or three halo, OH, OC 1-4 alkyl, aryl, het 1 , or het 2 .