Patent ID: 8232285

Claim:
A compound of formula I, or pharmaceutically acceptable salts thereof: Wherein m, n and A are independently selected from the group consisting of 0, 1, 2, 3, and 4; R1 is selected from the group consisting of H, alkyl, aryl, haloaryl, and fluoroaryl; Y is selected from the group consisting of a bond; X is selected from the group consisting of NR2, O, and S; R2 is selected from the group consisting of hydrogen, alkyl including lower alkyl, alkenyl, and alkynyl; R3 is selected from H, alkyl, alkenyl, and alkynyl; R4 is selected from H, alkyl, aryl, substituted aryl, heteroaryl, alkenyl, alkynyl, and S-alkyl; Each R5 and each R6 are independently selected from the group consisting of H, halogen, hydroxyl, nitrogen, amino, cyano, alkoxy, alkylthio, methylenedioxy, or haloalkyloxy; or alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, alkylcarboxy, carboxyamino, carboxyamido, aminocarbonyl, and alkylsulfonamido; Q is either absent or selected from the group consisting of —CO—, and —SO 2 —; R7 is selected from the group consisting of aryl, alkylaryl, heteroaryl, aryl substituted with one or more of alkyl, halogen, —NO 2 , alkyloxy, and heterocycles; W is selected from H or NR8R9; where R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, alkenyl, akynyl, COR13, —CO 2 R13, —CONR14R14, —SOR13, —SO 2 R13, —C(═S)R14, —C(═NH)R14, and —C(═S)NR14R15; or R8 and R9 together with the N they are bonded to optionally form a heterocycle or substituted heterocycle; Each Z is C—R10: Each R10 is independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, amino, cyano, alkoxy, alkylthio, methylenedioxy, or haloalkyloxy; alkyl, alkenyl, alkynyl, aryl, substituted aryl, heteroaryl, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, alkylcarboxy, carboxyamino, carboxyamido, aminocarbonyl, and alkylsulfonamido; and R11, R12, R13, R14, and R15 are independently selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, heteroaryl, oxaalkyl, oxaalkylaryl, and substituted oxaalkylaryl.