Patent ID: 7601839

Claim:
A method of inhibiting the activity of a protein kinase comprising contacting said protein kinase with a compound having formula VII: wherein L 1 and L 2 are bonds; R 1 is —C(O)NR 14 R 15 ; R 19 is independently halogen, —OR 5 , —NR 6 R 7 , or substituted or unsubstituted alkyl, wherein R 19 is —OR 5 at position 1, and wherein x is an integer from 1 to 5; R 20 is independently halogen, —OR 5 , —NR 6 R 7 , —C(O)NR 6 R 7 , —S(O) w R 9 , —CN, —NO 2 —CF 3 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein w is an integer from 0 to 2, and wherein y is an integer from 0 to 4, or two R 20 groups are optionally combined to form a substituted or unsubstituted ring with the carbons to which they are attached; R 5 is independently hydrogen, —CF 3 , substituted or unsubstituted alkyl; R 6 and R 7 are independently hydrogen, —C(X 2 )R 10 , —S(O) 2 R 11 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein X 2 is O, S, or NH; R 9 is independently hydrogen, —NR 17 R 18 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 10 and R 11 are independently hydrogen, —NR 12 R 13 , —OR 16 , —SR 16 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 12 and R 13 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 14 , R 15 , and R 16 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 17 and R 18 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or wherein R 6 and R 7 , R 12 and R 13 , R 14 and R 15 , and R 17 and R 18 are independently joined with the nitrogen to which they are attached to form substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted 5-membered heteroaryl.