Patent ID: 7732156

Claim:
A method of analysing the presence of human COMP (cartilage oligomeric matrix protein) in a clinical sample, comprising a) providing a first monoclonal antibody directed against human COMP, which first monoclonal antibody is bound to a solid phase carrier; b) adding a clinical sample suspected to contain human COMP together with the first monoclonal antibody of step a) and incubating the resulting mixture in aqueous solution; c) adding a second monoclonal antibody directed against human COMP to the mixture of step b), said second monoclonal antibody comprising a label emitting a detectable and quantifiable signal, where said second monoclonal antibody is not directed against the same COMP epitope as said first monoclonal antibody; and d) quantifying the signal from the label, said signal being a measurement of the concentration of human COMP in said sample, wherein said first monoclonal antibody and said second monoclonal antibody are different and are chosen from the monoclonal antibodies produced by cell lines deposited at the Deutsche Sammlung von Mikroorpanismen und Zellkulturen GmbH under the accession numbers DSM ACC2406, DSM ACC2408, and DSM ACC2418, respectively.