Patent ID: 8084262

Claim:
A method of determining the extent of interference of a bisphosphonate with steroid metabolism comprising: determining the presence or absence of a felinine derivative selected from the group consisting of gamma-glutamylfelinylglycine (3-methylbutanolgluthatione), felinylglycine, felinine or N-acetyl-felinine in a body fluid, and intact tissue or a tissue extract of a subject treated with said bisphosphonate, wherein the presence of said felinine derivative is indicative of a bisphosphonate which interferes with steroid metabolism, and the absence of said felinine derivative is indicative of a bisphosphonate which does not interfere with steroid metabolism wherein the extent of interference with farnesyl diphosphate production is determined, and wherein further the subject is a rat, and wherein further the bisphosphonate is selected from the group consisting of ibandronate and zoledronate.