Patent ID: 7192948

Claim:
A compound of Formula I wherein: R 1 is C 1-6 (Ar 1 )alkyl; R 2 is hydrogen, hydroxy, C 1-6 alkyl, or C 1-6 alkoxy; R 3 is hydrogen, halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, N(R 6 )SO 2 R 7 , N(R 6 )COR 7 , N(R 6 )CO 2 R 7 , OCOR 7 , OCO 2 R 7 , OCON(R 6 )(R 6 ), COR 7 , CO 2 R 6 , CON(R 6 )(R 6 ), SOR 7 , SO 2 R 7 , SO 2 N(R 6 )(R 6 ), or Ar 2 ; R 4 is hydrogen, halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, or C 1-6 haloalkoxy; R 5 is hydrogen, halo, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, or C 1-6 haloalkoxy; R 6 is hydrogen, C 1-6 alkyl, or C 3-7 cycloakyl; R 7 is C 1-6 alkyl or C 3-7 cycloalkyl; R 8 is hydrogen, C 1-6 alkyl, or benzyl; Ar 1 is Ar 2 is tetrazolyl, triazolyl, pyrazolyl, imidazolyl, pyrrolyl, or dixothiazinyl, and is substituted with 0–2 substituents selected from the group consisting of amino, oxo, halo, and C 1-6 alkyl; and X-Y-Z is SC(R 8 ) 2 C(R 8 ) 2 , SC(R 8 ) 2 C(R 8 ) 2 C(R 8 ) 2 , or SC(R 8 ) 2 C(R 8 ) 2 C(R 8 ) 2 C(R 8 ) 2 ; or a pharmaceutically acceptable salt or solvate thereof.