Patent ID: 8022227

Claim:
A method for making a 1H-indazole compound comprising: providing an aromatic carbonyl compound having the formula where R 1 is H, an alkyl, an aryl, or heteroaryl; R 2 is H, an alkyl, aryl, allyl, alkylsulfonyl, or arylsulfonyl; X is N or CY 4 ; Y 1 , Y 2 , Y 3 , and Y 4 independently represent H, an alkyl, aryl, alkoxy or halogen; and wherein optionally one or more of Y 1 and Y 2 , Y 2 and Y 3 , or Y 3 and Y 4 can be connected to form at least one ring; reacting said aromatic carbonyl compound with a nitrogen-containing base to form an oxime reaction product having the formula and adding an activating agent in the presence of a weak base to said oxime reaction product such that said oxime reaction product is converted to a 1H-indazole compound.