Patent ID: 7892818

Claim:
A screening, diagnostic and/or quantification kit or device for obtaining an activation profile of a biological sample comprising a plurality of transcription factors, said activation profile comprising an activation state of some or all of said transcription factors, said kit or device comprising: a solid support having on its surface a plurality of different capture molecules present in a predetermined spatial arrangement to form a micro-array able to specifically interact with one or more activated transcription factor(s) present in said biological sample and wherein the different capture molecules are present in different spots on the microarray and wherein the capture molecules contain a double-stranded DNA sequence comprising a specific sequence able to bind activated transcriptional factor(s) and a spacer comprising a double-stranded DNA sequence between about 50 and about 250 base pairs and wherein said double-stranded DNA sequence of between about 50 and about 250 base pairs is not present in said biological sample; and primary antibodies or fragments thereof specific for at least two of the said activated transcriptional factors.