Patent ID: 8222424

Claim:
A compound of formula (III) wherein R′ 1 is selected from hydrogen, alkyl, cycloakyl, R 5 C(O)—, R 6 SO 2 —, (R 7 )NH—C(O)—, and (R 8 )(R 9 )N—, aryl, heteroaryl, heterocycloalkyl, said aryl, heteroaryl, and heterocycloalkyl are optionally substituted by one or two substituents selected from alkyl-SO 2 —, alkyl-C(O)—, heterocycloalkyl-alkyl-, alkyl-alkoxy-, alkoxy-, alkyl, aryl, cycloalkyl, halo, alkoxy-alkyl-, alkyl-O—C(O)—, cycloalkyl-alkyl-, dialkylamino-alkoxy-, and dialkylamino-alkyl-; wherein R 5 , R 6 , R 7 , R 8 and R 9 are independently alkyl or aryl, each of which is optionally substituted by one to five substituents selected from the group consisting of (C 1 -C 7 ) alkyl, halo, hydroxy, (C 1 -C 7 ) alkoxy, and aryl; R 2 and R 3 are hydrogen; X is selected from hydrogen, cyano, halogen, nitro, alkyl-S—, alkyl-SO—, alkyl-SO 2 —, H 2 N—SO 2 —, R 5 —C(O)—, alkyl, and R 4 —O, wherein R 4 and R 5 are independently alkyl or aryl each of which is optionally substituted by substituents selected from the group consisting of (C 1 -C 7 ) alkyl, halo, hydroxy, (C 1 -C 7 ) alkoxy, and aryl; Y is C or N; or a pharmaceutically acceptable salt thereof, or an optical isomer thereof; or a mixture of optical isomers.