Patent ID: 7863451

Claim:
A process for preparing a compound of Formula 1: or a pharmaceutically acceptable salt, thereof, wherein: each of R 1â€² , R 2â€² , R 3â€² , and R 4â€² is at each occurrence independently hydrogen, halo, alkyl, alkoxy, â€”CF 3 , â€”CN, â€”NO 2 , â€”NHProtG 2 , or â€”NR 5 R 6 ; each of R 5 and R 6 is at each occurrence independently hydrogen or alkyl; R 7 is hydrogen, halo, alkyl, or benzyl; and ProtG 2 is a suitable N-protecting group, which comprises the alternative sequences of steps of: (1)(a) cyclizing a compound of Formula 2: and (b) optionally transforming one or more of the R 1 , R 2 , R 3 , and/or R 4 substituents of the cyclized product of Formula 3: into one or more of the corresponding R 1â€² , R 2â€² , R 3â€² , and/or R 4â€² substituents, respectively, of the compound of Formula 1 in one or more steps, or: (2)(a) transforming one or more of the R 1 , R 2 , R 3 , and/or R 4 substituents of a compound of Formula 2: into one or more of the corresponding R 1â€² , R 2â€² , R 3â€² , and/or R 4â€² substituents, respectively, of a compound of Formula 4: in one or more steps, and (b) cyclizing the transformed product of Formula 4, wherein, for both sequences of steps unless noted otherwise: each of R 1 , R 2 , R 3 , R 4 , R 1â€² , R 2â€² , R 3â€² , and R 4â€² is at each occurrence independently hydrogen, halo, alkyl, alkoxy, â€”CF 3 , â€”CN, â€”NO 2 , â€”NHProtG 2 , or â€”NR 5 R 6 ; each of R 5 and R 6 is at each occurrence independently hydrogen or alkyl; R 7 is hydrogen, halo, alkyl, or benzyl; R 8 is alkyl or benzyl; and ProtG 2 is a suitable N-protecting group, wherein the cyclizing is performed under acidic condition in an aprotic solvent at a temperature at which the aprotic solvent refluxes or the cyclizing is performed under basic condition in an aprotic solvent at a temperature from about 0 to about 5Â° C.