Patent ID: 8575344

Claim:
A process for preparing Voriconazole of the following Chemical Formula 1, comprising the steps of: 1) carrying out the Reformatsky-type coupling reaction between a compound of the following Chemical Formula 4 and a compound of the following Chemical Formula 5 to obtain a compound of the following Chemical Formula 3; 2) removing the substituents X 1 , X 2 and OSO 2 R from the compound of Chemical Formula 3 to obtain racemic Voriconazole of the following Chemical Formula 2, with the proviso that X 1 and X 2 are not removed when they both represent H; and 3) separating the isomers of the compound of Chemical Formula 2 with an optically active acid: wherein X 1 and X 2 independently represent H or halo; and R is C 1 -C 4 alkyl or substituted or non-substituted phenyl, wherein the substituted phenyl may be substituted with at least one substituent selected from the group consisting of C 1 -C 4 alkyl, alkoxy, halo, nitro and oxo.