Patent ID: 8119650

Claim:
A compound of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is an integer with value 0, 1 or 2 and when n is 0 then a direct bond is intended; m is an integer with value 1 or 2; X is N or CH; Y is O, S, or NR 8 ; wherein R 8 is hydrogen, C 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylmethyl, phenylC 1-6 alkyl, —C(═O)—CHR 9 R 10 or —S(═O) 2 —N(CH 3 ) 2 ; wherein each R 9 and R 10 is independently hydrogen, amino, C 1-6 alkyl or aminoC 1-6 alkyl; and when Y is NR 8 and R 2 is on the 7-position of the indolyl then R 2 and R 8 together can form the bivalent radical —(CH 2 ) 2 — (a-1), or —(CH 2 ) 3 — (a-2); R 1 is hydrogen, C 1-6 alkyl, hydroxyC 1-6 alkyl, cyanoC 1-6 alkyl, C 1-6 alkylsulfonyl, C 1-6 alkylcarbonyl or mono- or di(C 1-6 alkyl)aminosulfonyl; R 2 is hydrogen, hydroxy, amino, halo, C 1-6 alkyl, cyano, C 2-6 alkenyl, polyhaloC 1-6 alkyl, nitro, phenyl, C 1-6 alkylcarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkyloxy, or mono- or di(C 1-6 alkyl)amino; R 3 is hydroxy or amino; R 4 is hydrogen, thienyl, furanyl or phenyl and each thienyl, furanyl or phenyl can optionally be substituted with halo, amino, nitro, cyano, hydroxy, phenyl, C 1-6 alkyl, (diC 1-6 alkyl)amino, C 1-6 alkyloxy, phenylC 1-6 alkyloxy, hydroxyC 1-6 alkyl, C 1-6 alkyloxycarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonyl, polyhaloC 1-6 alkyloxy, polyhaloC 1-6 alkyl, C 1-6 alkylsulfonyl, hydroxycarbonylC 1-6 alkyl, C 1-6 alkylcarbonylamino, aminosulfonyl, aminosulfonylC 1-6 alkyl, isoxazolyl, aminocarbonyl, phenylC 2-6 alkenyl, phenylC 3-6 alkynyl or pyridinylC 3-6 alkynyl; R 5 , R 6 and R 7 are each independently hydrogen, amino, nitro, furanyl, halo, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, thienyl, phenyl, C 1-6 alkylcarbonylamino, aminocarbonylC 1-6 alkyl or —C≡C—CH 2 —R 1 .