Patent ID: 7550562

Claim:
A peptide containing an epitope specifically recognized by a monoclonal antibody comprising an H chain which has the amino acid sequence shown in SEQ ID NO: 4 and functions as an H chain of an anti-human Dsg3 monoclonal Fab antibody and an L chain which has the amino acid sequence shown in SEQ ID NO: 6 and functions as an L chain of an anti-human Dsg3 monoclonal Fab antibody, wherein the peptide is a) a point-mutated human Dsg3 molecule comprising T25H, Y28C and Q29A mutations and no other mutations in SEQ ID NO: 56, b) a point-mutated human Dsg3 molecule comprising T31N, K33Q and I34V mutations and no other mutations in SEQ ID NO: 56, c) a point-mutated human Dsg3 molecule comprising V53I, D54N, K55Q and N56K mutations and no other mutations in SEQ ID NO: 56, d) a point-mutated human Dsg3 molecule comprising E70V and S73F mutations and no other mutations in SEQ ID NO: 56, e) a point-mutated human Dsg3 molecule comprising L75I and T77Y mutations and no other mutations in SEQ ID NO: 56, f) a point-mutated human Dsg3 molecule comprising A83S and Q84M mutations and no other mutations in SEQ ID NO: 56, g) a point-mutated human Dsg3 molecule comprising T25H, Y28C, Q29A, T31N, K33Q and I34V mutations and no other mutations in SEQ ID NO: 56, h) a point-mutated human Dsg3 molecule comprising T25H, Y28C, Q29A, T31N, K33Q, I34V, F48Y, V53I, D54N, K55Q and N56K mutations and no other mutations in SEQ ID NO: 56, i) a point-mutated human Dsg3 molecule comprising a D59E mutation and no other mutations in SEQ ID NO: 56, or j) a point-mutated human Dsg1 molecule comprising I3V, A7K, A8P and E59D mutations and no other mutations in SEQ ID NO: 57.