Patent ID: 7326546

Claim:
A method for producing a purine-derived substance comprising: a) culturing a Bacillus bacterium in a medium; and b) collecting said purine-derived substance, wherein said Bacillus bacterium is able to produce a purine-derived substance and has been modified to increase glucose-6-phosphate dehydrogenase activity by increasing the copy number of the gene encoding glucose-6-phosphate dehydrogenase or modifying an expression control sequence of the gene encoding glucose-6-phosphate dehydrogenase, wherein said glucose-6-phosphate dehydrogenase is selected from the group consisting of: (A) a protein comprising the amino acid sequence of SEQ ID No. 48, and (B) a modified protein comprising the amino acid sequence of SEQ ID No. 48 wherein one to 10 amino acids are substituted, deleted, inserted, or added, and said modified protein has glucose-6-phosphate dehydrogenase activity.