Patent ID: 6859735

Claim:
A computer system for determining a representation of measured drug response of a cell type to a drug in terms of one or more biological pathway responses, said computer system comprising a processor and a memory coupled to said processor, said memory encoding one or more programs, said one or more programs causing said processor to perform a method comprising the steps of: (a) receiving a drug response of said drug in said cell type, said drug response comprising quantitative measurements of a plurality of cellular constituents in a cell of said cell type at a plurality of levels of drug exposure; (b) receiving one or more biological pathway responses, each of said one or more biological pathway responses comprising quantitative measurements of cellular constituents of a biological pathway in a cell of said cell type at a plurality of levels of a perturbation to said biological pathway, said one or more biological pathway responses comprising at least one biological pathway response from a biological pathway that is likely to be involved in action of said drug in said cell type; (c) forming a model drug response as a combination of said one or more biological pathway responses, wherein each of said one or more biological pathway responses in said combination is subject to an independent scaling transformation; (d) determining the value of a function of the difference between said drug response and said model drug response; and (e) minimizing said determined value of said function by varying the scaling transformations of said one or more biological pathway responses to obtain scaling transformations that minimize said determined value of said function; wherein said combination of said one or more biological pathway responses subject to said scaling transformations is a representation of said measured drug response of said cell type to said drug.