Patent ID: 8759309

Claim:
A method of treating an animal to enhance, restore or stimulate its immune response comprising: administering to an animal in need thereof a therapeutically effective amount of a polynucleotide wherein said nucleotide comprises: (a) a full length complement to one or more Initiation Sites in the Origins of Replication of bacteria, fungi and virions, (b) a nucleic acid sequence selected from: 5′ UAUU 3′, 5′ CCACA3′, 5′ AAUA 3′, 5′ GGUGU 3′, 5′ UUAUA 3′, 5′ UUA 3′, 5′AUAA 3′, 5′UUAU 3′, 5′AAA 3′, 5′ UUU 3′, 5′ AAUA 3′, 5′ UUAU 3′, 5′ AUAA 3′, 5′ UAUU 3′, 5′ AAUAU 3′, 5′ UUAUA 3′, and 5′UGUG′3; or (c) a nucleic acid sequence which has 90% or greater sequence similarity to (a), wherein the polynucleotide contacts a neutophil or neutrophils belonging to the animal's immune network, and wherein said polynucleotide enhances, restores or stimulates the immune response of said neutrophil or neutrophils.