Patent ID: 8143291

Claim:
A compound having the structure: wherein: each Ar is independently substituted or unsubstituted phenyl or pyridine or thiophene or oxazole; each L is independently alkylene, alkenylene, oxyalkylene, oxyalkenylene, aminoalkylene, or aminoalkenylene; R 1 is lower alkyl or alkylacyl or hydroxyalkyl; each R 2 is independently H, lower alkyl, halide, trifluoromethyl, lower alkenyl, lower alkynyl, cycloalkyl, —CN, —CH 2 CN, —CH 2 SR 3 , —CH 2 N(R 3 ) 2 , —CH 2 OR 3 , —CH═NOR 3 , —OR 3 , —SR 3 , —N(R 3 ) 2 , —C(O)R 4 , heterocycle, substituted heterocycle, aryl, substituted aryl, heteroaryl, substituted heteroaryl; or R 2 is wherein R 5 is —CO 2 H or PO 3 H 2 and p is 0-2; or when n is 2, each R 2 taken together with carbon atoms to which each R 2 is attached forms an aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl or substituted cycloalkyl; each R 3 is independently H, lower alkyl, cycloalkyl, allyl, phenyl, substituted phenyl, heteroaryl, or substituted heteroaryl; each R 4 is independently H, lower alkyl, cycloalkyl, alkoxy, alkylamino, dialkylamino, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, or trifluoromethyl; E is O x is 1; and n is 0-5; or a pharmaceutically acceptable salt thereof.