Patent ID: 8044052

Claim:
A compound of Formula I wherein: each R 1 is independently hydrogen, —OH, halogen, haloalkyl, —C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, aryl, heteroaryl, —O-aryl, —O-heteroaryl, —NH 2 , —NHC(O)C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —NHC(O)C 3 -C 6 cycloalkyl, —NHC 1 -C 6 alkyl, CN, —C(O)NR′R″ or —C(O)C 1 -C 6 alkyl; with each R 1 —C 1 -C 6 alkyl group being optionally substituted by an —O—C 1 -C 6 alkyl group or from 1 to 3 —OH substituents; R′ and R″ are independently selected from H or C 1 -C 6 alkyl; R 2 is pyridazine; each R 3 is independently hydrogen, halogen, haloalkyl, —C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —S—C 3 -C 6 cycloalkyl and —O—C 3 -C 6 cycloalkyl; said R 3 —C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —S—C 3 -C 6 cycloalkyl and —O—C 3 -C 6 cycloalkyl, groups are optionally substituted with from 1 to 4 halogen, haloalkyl, —O-haloalkyl, —C 1 -C 6 alkyl, or —O(C 1 -C 6 alkyl) substituents; R 4 is hydrogen, —C 1 -C 6 alkyl, phenyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl or halogen; said R 4 —C 1 -C 6 alkyl, phenyl, and —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl groups being optionally substituted with from 1 to 4 halogen, —C 1 -C 6 alkyl, or —O(C 1 -C 6 alkyl) substituents; X is N or CH; m is 0, 1, 2, 3, or 4; n is 0, 1, 2, 3 or 4; and Ar is aryl, —CH 2 -aryl, or heteroaryl, with said aryl, —CH 2 -aryl and heteroaryl groups being optionally independently substituted with from 1 to 4 substituents selected from hydrogen, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, halogen, haloalkyl, —O-haloalkyl, —C(O)C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —O—C 2 -C 6 alkenyl, —O—C 2 -C 6 alkynyl, CN, aryl, heterocyclyl or heteroaryl; said —C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —C(O)C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl), —S—C 1 -C 6 alkyl, aryl, —CH 2 -aryl, heterocyclyl and heteroaryl substituents on Ar are optionally independently substituted with from 1 to 4 —C 1 -C 6 alkyl, —C 1 -C 6 alkoxy, —OH, or halogen substituents; or a pharmaceutically acceptable salt thereof.