Patent ID: 8097722

Claim:
An inhibitor of the enzyme prenylated methylated protein methyl esterase (PMPMEase), which has the formula where R 1 is a group selected from substituted or unsubstituted prenyl or polyisoprenyl; X is a linking group; the two atoms between the X and Y groups are the bridge and are selected from C, N, O, and S; R 2 is a group selected to impart increased aqueous solubility or potency, and includes an open chain alkyl, alicyclic, aryl, or aryloxy group containing one or more salt-forming basic or acidic groups separated from the bridge by a tether; and Y is selected from where R 3 is alkyl, substituted alkyl, aryl, substituted aryl, SR 5 , OR 5 (except carboxyl esters), NHR 5 or NR 5 R 6 , R 4 is alkyl, substituted alkyl, aryl or substituted aryl and R 5 and R 6 are alkyl, substituted alkyl, aryl or substituted aryl; and wherein if Y is and the bridge atoms are both C then R 3 is not OR 5 .