Patent ID: 6930102

Claim:
Epothilone derivatives of general formula I, in which R 1a , R 1b are the same or different and mean hydrogen, C 1 -C 10 alkyl, aryl, C 7 -C 20 aralkyl, or together a —(CH 2 ) n group with m=2, 3, 4 or 5, R 2a , R 2b are the same or different and mean hydrogen, C 1 -C 10 alkyl, aryl, C 7 -C 20 aralkyl or together a —(CH 2 ) n group with n=2, 3, 4 or 5, R 3 means hydrogen, C 1 -C 10 alkyl, aryl, C 7 -C 20 aralkyl, G means an oxygen atom or a group —CH 2 , R 4a , R 4b are the same or different and mean hydrogen, C 1 -C 10 alkyl, aryl, C 7 -C 20 aralkyl or together a —(CH 2 ) p group with p=2, 3, 4 or 5, D—E means a group R 5 means hydrogen, C 1 -C 10 alkyl, aryl, C 7 -C 20 aralkyl, CO 2 H, CO 2 -alkyl, CH 2 OH, CH 2 O-alkyl, CH 2 O-acyl, CN, CH 2 NH 2 , CH 2 N (alkyl, acyl) 1,2 , CH 2 Hal R 6 , R 7 each mean a hydrogen atom, together an additional bond or an oxygen atom, R 8 means a halogen atom, or a cyano group, X means an oxygen atom, two alkoxy groups OR 23 , a C 2 -C 10 alkylene-α,ω-dioxy group, which can be straight-chain or branched, H/OR 9 or a grouping CR 10 R 11 , whereby R 23 stands for a C 1 -C 20 alkyl radical, R 9 stands for hydrogen or a protective group PG x , R 10 , R 11 are the same or different and stand for hydrogen, a C 1 -C 20 alkyl, aryl, C 7 -C 20 aralkyl radical or R 10 and R 11 together with the methylene carbon atom together stand for a 5- to 7-membered carbocyclic ring, T—Y means a group NR 24 —C(═O), or NR 24 —SO 2 , R 24 means hydrogen, C 1 -C 10 alkyl, Z means an oxygen atom or H/OR 12 , whereby R 12 is hydrogen or a protective group PG z .