Patent ID: 8080569

Claim:
A method of treating a patient for a condition which responds to the stimulation of the expression of endothelial NO synthase, the method comprising administering to the patient a pharmaceutically effective dose of a compound of formula I, in which R is selected from halogen, (C 1 -C 6 )-alkyl, (C 1 -C 3 )-alkoxy-(C 1 -C 3 )-alkyl, hydroxy, (C 1 -C 6 )-alkoxy which can be substituted by one or more fluorine atoms, (C 1 -C 6 )-alkylmercapto, —NH 2 , (C 1 -C 6 )-alkylamino, di-((C 1 -C 6 )-alkyl)amino, mono-(C 1 -C 6 )-alkylaminocarbonyl, di-(C 2 -C 6 )-alkylaminocarbonyl, (C 1 -C 6 )-alkoxycarbonyl, cyano, (C 1 -C 6 )-alkylsulfinyl, (C 1 -C 6 )-alkylsulfonyl, aminosulfonyl, nitro, and pentafluorosulfanyl, wherein said (C 1 -C 6 )-alkyl can be substituted by one or more fluorine atoms; R1 is selected from hydrogen and (C 1 -C 6 )-alkyl; R2 is selected from hydrogen and (C 1 -C 6 )-alkyl; R3 is selected from cyano, and —C(═O)—NR6R7; R6 and R7 are independently selected from hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, —(CH 2 ) q —(C 6 -C 14 )-aryl, and —(CH 2 ) p -heteroaryl, wherein the aryl and heteroaryl residues can be substituted by one or more identical or different substituents selected from halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy and trifluoromethyl; or R6 and R7 form together with the nitrogen atom which carries them a 4-membered to 7-membered, saturated, partially unsaturated or aromatic heterocyclic ring which can be substituted by one or more identical or different substituents R1 and which, in addition to the nitrogen atom connecting R6 and R7, can contain one or two further ring members selected from ═N—, —NR1-, —C(═O)—, —O—, —S—, —SO— and —SO 2 —, which can be identical or different, with the proviso that two ring members from the series —O—, —S—, —SO— and —SO 2 — cannot be present in adjacent ring positions; n is selected from 0, 1, 2, 3, 4 and 5; p and q are independently selected from 0, 1, 2, 3, 4 and 5; or a physiologically acceptable salt thereof.