Patent ID: 8632980

Claim:
A method of predicting whether a human patient diagnosed with colorectal cancer has an increased or decreased likelihood of a positive clinical response to treatment with chemotherapy, comprising: extracting RNA from a fixed, paraffin-embedded colorectal cancer tissue sample obtained from the patient; quantitatively measuring a level of an RNA transcript of HNRPD; normalizing the level of the RNA transcript of HNRPD to obtain a normalized HNRPD expression level; using a computer-implemented program to compare the normalized HNRPD expression level to a statistical model-predicted relationship between normalized HNRPD expression level and likelihood of positive response to treatment with chemotherapy determined from a population of at least 679 patients with colorectal cancer treated with chemotherapy and with known clinical outcome and a population of at least 578 patients with colorectal cancer not treated with chemotherapy and with known clinical outcome; and generating a report comprising a prediction whether the patient has an increased or decreased likelihood of exhibiting a positive response to chemotherapy.