Patent ID: 7264937

Claim:
A method for identifying an agonist of HM74 comprising, contacting a potential agonist with a cell expressing HM74 and determining whether in the presence of said potential agonist the signaling activity of HM74 is increased relative to the activity of HM74 in the absence of said potential agonist, wherein said potential agonist has the structure: where X is O, NR 2 or S; R 1 is a C 1 -C 18 alkyl, which may be branched, may contain a heteroatom or may be substituted, or combinations thereof; a C 1 -C 18 alkenyl, which may be branched, may contain a heteroatom or may be substituted, or combinations thereof; a C 1 -C 18 alkynl, which may be branched, may contain a heteroatom or may be substituted, or combinations thereof: a C 3 -C 18 aryl which may contain a side group, may contain a bridge, may contain a heteroatom or may be substituted, or combinations thereof; or a C 5 -C 18 cycloalkyl which may contain a side group, may contain a bridge, may contain a heteroatom or may be substituted, or combinations thereof; or combinations thereof; R2 is an R1 group, a (C1-C10) alkyl-(C3-C10) cycloalkyl, which may be branched, may contain a heteroatom or may be substituted, or combinations thereof; or X and R2 may form a ring; R3 is H or R1; and Y is carbonyl, a Schiff base, an oxine, a ketal, an acetal, an oxazolidine, a thiazolidine or an enol ester.