Patent ID: 8293923

Claim:
A compound of Formula (I) wherein: R 1 is an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl; R 2 is H, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl; each of a, a′, b, and c is independently N or C(R 3 ); each of R 3 , R 5 , and R 6 is independently H, an optionally substituted aliphatic, an optionally substituted alkoxy, acyl, halo, hydroxy, amino, nitro, cyano, guanadino, amidino, carboxy, sulfo, mercapto, sulfanyl, sulfinyl, sulfonyl, sulfonamide, amido, sulfamide, urea, thiourea, carbamoyl, cycloaliphatic, cycloalkyloxy, heterocycloaliphatic, heterocycloalkyloxy, aryl, aralkyl, aryloxy, aroyl, heteroaryl, heteroaralkyl, heteroaryloxy, or heteroaroyl; R 4 is H; K is —N(R X′ )—; J is a bond, —O—, —S(O) i —, —N(R X′ )—, alkylene, —C(O)—, —C(O)—O—, —C(O)—N(R X′ )—, —(CH 2 ) p N(R X′ )—, or —N(R X′ )—C(O)—; R X′ is independently H or an optionally substituted aliphatic; n is 0, 1, 2, or 3; i is 0, 1, or 2; p is 1, 2, 3, or 4; and provided that when R 1 is an unsubstituted alkyl and J is —O—, then R 2 is H, an optionally substituted aliphatic, an optionally substituted aryl, or an unsubstituted heteroaryl.