Patent ID: 7524875

Claim:
A modified bio-related substance, comprising a bio-related substance and at least one poly(alkylene glycol)oxy group bonded to said bio-related substance, said at least one poly(alkylene glycol)oxy group being represented by the following formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA 1 and OA 2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA 2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000, wherein said modified bio-related substance is formed by reacting a functional group X of an intermediate represented by formula (2) with a functional group of the bio-related substance: wherein X is at least one selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (xx1), (xx2) and (xx3): wherein Z represents a linking group containing an alkylene group or an alkylene group containing an ether bond, an ester bond, a urethane bond, an amide bond, a carbonate bond, or a secondary amino group and Y represents a hydrocarbon group having 1 to 10 carbon atoms which may contain fluorine atom(s); and W 1 represents a halogen atom selected from Cl, Br and I.