Patent ID: 8846693

Claim:
A compound of formula Q: wherein (i) R 1 is H or C 1-6 alkyl; (ii) R 2 is H, C 1-6 alkyl, C 3-8 cycloalkyl optionally substituted with one or more amino, C 3-8 heterocycloalkyl optionally substituted with C 1-6 alkyl, C 3-8 cycloalkyl-C 1-6 alkyl, C 1-6 haloalkyl, C 0-6 alkylaminoC 0-6 alkyl, hydroxyC 1-6 alkyl, arylC 0-6 alkyl, heteroarylalkyl, C 1-6 alkoxyarylC 1-6 alkyl, or -G-J wherein: G is a single bond or, alkylene; J is cycloalkyl or heterocycloalkyl optionally substituted with alkyl; (iii) R 3 is a) -D-E-F wherein 1. D is single bond, C 1-6 alkylene or arylC 1-6 alkylene; 2. E is a C 1-6 alkylene, arylene, C 1-6 alkylarylene, aminoC 1-6 alkylene or amino; and 3. F is heteroC 3-8 cycloalkyl substituted with C 1-6 alkyl or F is pyrrolidin-1-yl, pyrrolidin-2-yl or piperidin-2-yl; (iv) R 4 is aryl optionally substituted with one or more halo, hydroxy or C 1-6 alkoxy; heteroaryl; or heteroC 3-6 cycloalkyl; and (v) R 5 is H, C 1-6 alkyl, C 3-8 cycloalkyl, heteroaryl, aryl or p-benzylaryl; in free or salt form.