Patent ID: 8105627

Claim:
An extended release coated tablet formulation for venlafaxine, comprising a tablet which consists of: (a) a core comprising a pharmaceutically effective amount of venlafaxine or a pharmaceutically acceptable salt thereof, said core being in a form of a tablet, and said core further comprising: (i) at least 40% of a filler, weight per weight of the entire formulation; (ii) at least 5% of a water soluble cellulosic polymer selected from the group consisting of hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose and carboxymethyl cellulose, weight per weight of the entire formulation; (iii) at least 5% of ethyl cellulose, weight per weight of the entire formulation; (b) a coating for said core, said coating comprising: (i) a water soluble cellulosic polymer that is hydroxypropyl methylcellulose (HPMC); and (ii) a water insoluble cellulosic polymer that is ethyl cellulose, the tablet formulation having a dissolution profile in USP Apparatus 1 (basket) at 100 rpm in phosphate buffer at pH 6.8 according to a table: Time (hours) Average % Venlafaxine released 2 <30 4 25- 45 8 55- 75 12 75- 95 24 >80