Patent ID: 8809336

Claim:
A method of treating a disease or condition comprising or arising from abnormal cell growth or abnormally arrested cell death in a mammal, wherein the disease or condition is selected from a carcinoma of the bladder, breast, colon, kidney, epidermal, liver, lung, oesophagus, gall bladder, ovary, pancreas, stomach, cervix, endometrium, thyroid, prostate, or skin; a hematopoietic tumour of lymphoid lineage; a hematopoietic tumour of myeloid lineage; a tumour of mesenchymal origin; a tumour of the central or peripheral nervous system; melanoma; seminoma; teratocarcinoma; osteosarcoma; xenoderoma pigmentosum; keratoctanthoma; thyroid follicular cancer; and Kaposi's sarcoma; which method comprises administering to the mammal a therapeutically effective amount of a compound of the formula (I): or a salt, tautomer or N-oxide thereof, wherein; T is N; J 1 -J 2 is HC═CH; Q 1 and Q 2 each represent a bond; G is NR 2 R 3 ; R 1 is hydrogen; R 2 and R 3 are independently selected from hydrogen and methyl; R 4 is hydrogen; and E is a piperidine group bearing 0-1 substituents R 11 selected from the group R 10 consisting of halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, mono- or di-C 1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group R a -R b wherein R a is a bond, O, CO, X 1 C(X 2 ), C(X 2 )X 1 , X 1 C(X 2 )X 1 , S, SO, SO 2 , NR c , SO 2 NR c or NR c SO 2 ; and R b is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C 1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, carboxy, amino, mono- or di-C 1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C 1-8 hydrocarbyl group may optionally be replaced by O, S, SO, SO 2 , NR c , X 1 C(X 2 ), C(X 2 )X 1 or X 1 C(X 2 )X 1 ; R c is selected from hydrogen and C 1-4 hydrocarbyl; and X 1 is O, S or NR c and X 2 is ═O, ═S or ═NR c ; provided that where the substituent group R 10 comprises or includes a carbocyclic or heterocyclic group, the said carbocyclic or heterocyclic group may be unsubstituted or may itself be substituted with one or more further substituent groups R 10 wherein (i) the said further substituent groups R 10 include carbocyclic or heterocyclic groups, which are not themselves further substituted; or (ii) the said further substituent groups R 10 do not include carbocyclic or heterocyclic groups but are otherwise selected from the groups listed above in the definition of R 10 .