Patent ID: 7553842

Claim:
A compound including resolved enantiomers, diastereomers; and pharmaceutically acceptable salts thereof, said compound having the Formula I: wherein: X is alkyl, alkenyl, or alkynyl, wherein said alkyl, alkenyl and alkynyl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, aryl, COOR 1 , and a fully unsaturated or partially unsaturated five or six-membered heterocyclic ring having one to four heteroatoms independently selected from N, O and S, wherein said heterocyclic ring is optionally substituted with oxo; A is O; or A represents a carbon atom and an oxygen atom each bonded to carbon 32 of Formula I and which together complete a saturated or partially unsaturated five, six or seven membered spirocyclic lactone ring; Y is H or R 3 —SC(═O), or Y is wherein said Y groups are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, OR 4 , SR 4 , and NR 4 R 5 ; and L is alkylene, Z m -E-Z, NR 2 C(═O)Z, C(═O)NR 2 Z, D-Ar—NR 2 C(═O), OArC(═O)CH 2 , S-Z-NHC(═O)or wherein the asterisk indicates the point of attachment to Y; or Y is R 3 —SC(═O) or Y is wherein said Y groups are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, OR 4 , SR 4 , and NR 4 R 5 and L is absent, alkylene, Z m -E-Z, NR 2 C(═O)Z, C(═)NR 2 Z, D-Ar—NR 2 C(═O), OArC(═O)CH 2 , S-Z-NHC(═O) or wherein the asterisk indicates the point of attachment to Y; Z is C 1 -C 4 alkylene optionally substituted with one or more groups selected from alkyl, F, Cl, Br or I: Ar is arylene optionally substituted with one or more groups independently selected from F, Cl, Br and I; D is CH 2 , O, S, SO, or SO 2 ; E is O, S, NR 2 , or OC(═O); m is 0 or 1; j is 1, 2, 3, 4, or 5; R 1 is H, alkyl, alkenyl, alkynyl, or aryl, wherein said aryl is optionally substituted with one or more groups independently selected from F, Cl, Br and I; R 2 is H or alkyl; R 3 is alkyl, alkenyl, or alkynyl, wherein said alkyl, alkenyl, and alkynyl are optionally substituted with one or more groups independently selected from F, Cl, Br, and I; and R 4 and R 5 are independently H, alkyl or aryl.