Patent ID: 7423038

Claim:
A compound of formula I: in which: Y is selected from C, and S(O); R 1 is selected from hydrogen, C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-10 cycloalkyl-C 0-4 alkyl and C 3-10 heterocycloalkyl-C 0-4 alkyl; R 2 is selected from hydrogen and C 1-6 alkyl; or R 1 and R 2 together with the nitrogen atom to which R 1 and R 2 are attached form C 3-10 heterocycloalkyl or C 5-10 heteroaryl; wherein any alkyl of R 1 can be optionally substituted by one to three radicals independently chosen from halo, C 1-6 alkoxy and —XNR 7 R 8 ; wherein X is a bond or C 1-6 alkylene; and R 7 and R 8 are independently chosen from hydrogen and C 1-6 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 1 , or the combination of R 1 and R 2 , is optionally substituted by one to three radicals chosen from halo, hydroxy, C 1-6 alkyl, —XOXNR 7 R 8 and —XR 10 ; wherein X is a bond or C 1-6 alkylene; R 7 and R 8 are independently chosen from hydrogen and C 1-6 alkyl; and R 10 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-10 cycloalkyl and C 3-10 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 10 is optionally substituted by 1 to 3 radicals chosen from halo, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy and —XNR 7 R 8 radicals; wherein X is a bond or C 1-6 alkylene; and R 7 and R 8 are independently chosen from hydrogen and C 1-6 alkyl; R 3 and R 4 are independently chosen from hydrogen and C 1-6 alkyl; R 5 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, halo-substituted-C 1-4 alkyl and halo-substituted-C 1-4 alkoxy; R 6 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-10 cycloalkyl and C 3-10 heterocycloalkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 6 is optionally substituted by one to three radicals independently chosen from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 7 R 7 , —XNR 7 XNR 7 R 7 , —XNR 7 C(O)R 7 , —XC(O)OR 7 , —XNR 7 S(O) 2 R 7 , —XNR 7 S(O)R 7 , —XNR 7 SR 7 and —XR 11 ; wherein X and R 7 are as defined above and R 11 is selected from the group consisting of C 5-10 heteroaryl-C 0-4 alkyl and C 3-10 heterocycloalkyl-C 0-4 alkyl; wherein any heteroaryl or heterocycloalkyl of R 11 is optionally substituted with a radical selected from the group consisting of C 1-6 alkyl, halo-substituted-C 1-6 alkyl and —C(O)OR 7 ; and the pharmaceutically acceptable salts thereof.