Patent ID: 7615649

Claim:
A method to prepare a compound of Formula A: wherein X, Y, X 1 , Y 1 , Z 1 and X 2 , Y 2 , and Z 2 are individually H, OH, N(R) 2 , (C 1 -C 6 )alkoxy, or (C 2 -C 6 )alkanoyloxy; G is H, OH, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkanoyloxy, N(R) 2 , or NO 2 ; W is H, OH, (C 2 -C 6 )alkyl; (C 1 -C 6 )alkoxy, (C 1 -C 6 )hydroxyalkyl or (C 1 -C 6 )alkoxylcarbonyl(C 1 -C 6 )alkyl; Q is H or a single bond to C 8 of a compound of formula (C) wherein Q is H; each R is H, (C 1 -C 4 )alkyl, (C 2 -C 6 )alkanoyl, or (C 6 -C 14 )arylC(O), wherein aryl can be substituted with 1, 2, or 3 X; by reacting a compound of Formula (B): wherein An − is a pharmaceutically acceptable anion, with a compound of Formula (C): in solution in a (C 1 -C 4 )alkanol or mixture thereof, in the absence of water, and; recovering the compound of Formula (A).