Patent ID: 7041839

Claim:
A compound having the structural formula, wherein said compound has a message unit at the 17α-position of an address unit, comprising: a) an address unit having the structure: wherein: R 1 is H, CH 3 , CH 2 CH 3 , OH, OCH 3 , OCH 2 CH 3 , C 1 –C 6 alkyl, CH═CH 2 , CH═CHCH 3 , CH 2 −aryl; R 2 is H, CH 3 , COCH 3 , CO(CH 2 ) n CH 3 , CO−aryl, alkyl, cycloalkyl (ether), ester; and R 3 is H, CH 3 , CH 2 CH 3 , aryl, heteroaryl, C 1 −C 6 alkyl, alkyl (C 1 −C 6 ) amides, alkyl (C 1 –C 6 ) sulfide, alkyl (C 1 –C 6 ) sulfone, alkyl (C 1 –C 6 ) sulfoxide; and b) a message unit having the structure; wherein: R 4 is H, C 1 –C 4 alkyl; R 5 is substituted aryl, heteroaryl, fused aryl, —CO-aryl, CO-fused aryl, —CO-heteroaryl, —CO-fused heteroaryl, biaryl, CO-biaryl, ether-linked aryls, ether-linked heteroaryls, amine-linked aryls, amine-linked heteroaryls, aminoalkoxy arene hybrid, or peptidyl hybrid, wherein any substituted aryl, heteroaryl, fused aryl, —CO-aryl, CO-fused aryl, —CO-heteroaryl, —CO-fused heteroaryl, biaryl, CO-biaryl, ether-linked aryls, ether-linked heteroaryls, amine-linked aryls, amine-linked heteroaryls, aminoalkoxy arene hybrid and peptidyl hybrid, may optionally be substituted, independently, with H, CH 3 , OH, OCH 3 ,OCF 3 , N(CH 3 ) 2 , NHCOCH 3 , aryl, CO 2 CH 3 , CONH 2 , C 1 –C 4 alkyl, (CF 2 ) n F wherein n=1−4, Cl, Br, I, F, O(CH 2 ) n H wherein n=1−4, NO 2 , NH 2 , NHCOR 4 , CO 2 H, CO 2 R 4 , CONHR 4 , amyl, thioether, SR 6 , S(O)R 6 , SO 2 NR 6 R 7 ; wherein R 4 has the definition given above; wherein R 6 is H, C 1 –C 4 alkyl or perfluoroalkyl, aryl, heteroaryl, optionally substituted allyl, arylmethyl, alkynyl, or alkenyl; wherein R 7 is H, C 1 –C 4 alkyl or perfluoroalkyl, aryl, heteroaryl, optionally substituted allyl, arylmethyl, OR 8 or NHR 8 ; wherein R 8 is H, C 1 –C 6 alkyl or perfluoroalkyl, aryl, heteroaryl, optionally substituted allyl, arylmethyl, SO 2 R 6 or S(O)R 6 , wherein R 6 has the definition given above; and wherein R 5 can be in either the E or Z configuration in relation to the 17α-position of said address unit.