Patent ID: 7514409

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: A is N or N + —O − ; X and Y are independently selected from halogen, C 1-3 alkyl, and C 1-3 alkoxy; R 1 is selected from (1) hydrogen, (2) C 1-10 alkyl, (3) —(C 1-10 alkyl)-aryl, (4) —(C 1-10 alkyl)-O—C 1-10 alkyl, (5) —(C 1-10 alkyl)-OC(O)—C 1-10 alkyl, (6) —(C 1-10 alkyl)-OC(O)-aryl, (7) —(C 1-10 alkyl)-OC(O)O—C 1-10 alkyl and (8) —(C 1-10 alkyl)N + (C 1-3 alkyl) 3 ; wherein alkyl is optionally substituted with one to three substituents independently selected from R a , and aryl is optionally substituted with one to three substituents independently selected from R b ; R 2 is hydrogen or methyl; R 3 and R 4 are independently selected from (1) hydrogen, (2) —NR d R e , (3) —NR d S(O) m R e , (4) —NR d C(O)R e , (5) —NR d C(O)OR e , and (6) —NR d C(O)NR d R e , with the proviso that R 3 and R 4 are not both hydrogen; R a is selected from (1) —OR d , (2) —NR d S(O) m R e , (3) —NO 2 , (4) halogen, (5) —S(O) m R d , (6) —SR d , (7) —S(O) 2 OR d , (8) —S(O) m NR d R e , (9) —NR d R e , (10) —O(CR f R g ) n NR d R e , (11) —C(O)R d , (12) —CO 2 R d , (13) —CO 2 (CR f R g ) n CONR d R e , (14) —OC(O)R d , (15) —CN, (16) —C(O)NR d R e , (17) —NR d C(O)R e , (18) —OC(O)NR d R e , (19) —NR d C(O)OR e , (20) —NR d C(O)NR d R e , (21) —CR d (N—OR e ), (22) CF 3 , (23) —OCF 3 , (24) C 3-8 cycloalkyl, and (25) heterocyclyl; wherein cycloalkyl and heterocyclyl are optionally substituted with one to three groups independently selected from R c ; R b is selected from (1) a group selected from R a , (2) C 1-10 alkyl, (3) C 2-10 alkenyl (4) C 2-10 alkynyl, (5) aryl, and (6) —(C 1-10 alkyl)-aryl, wherein alkyl, alkenyl, alkynyl, and aryl are optionally substituted with one to three substituents selected from a group independently selected from R c ; R c is (1) halogen, (2) amino, (3) carboxy, (4) C 1-4 alkyl, (5) C 1-4 alkoxy, (6) aryl, (7) —(C 1-4 alkyl)-aryl, (8) hydroxy, (9) CF 3 , (10) OC(O)C 1-4 alkyl, (11) OC(O)NR f R g , or (12) aryloxy; R d and R e are independently selected from hydrogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, Cy and —(C 1-10 alkyl)-Cy, wherein alkyl, alkenyl, alkynyl and Cy are optionally substituted with one to four substituents independently selected from R c ; or R d and R e together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from O, S and N—R h , and wherein said heterocyclic ring is optionally fused with a C 3-8 carbocyclic ring or is optional substituted with 1 to 4 groups independently selected from C 1-10 alkyl; R f and R g are independently selected from hydrogen, C 1-10 alkyl, Cy and —(C 1-10 alkyl)-Cy; or R f and R g together with the carbon to which they are attached form a ring of 5 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen; R h is selected from R f and —C(O)R f ; Cy is selected from cycloalkyl, heterocyclyl, aryl, and heteroaryl; and m is 1 or 2.