Patent ID: 8586019

Claim:
A conjugate comprising a polymeric backbone having attached thereto a therapeutically active agent and an angiogenesis targeting moiety, said angiogenesis targeting moiety comprising a least one Arg-Gly-Asp (RGD)-containing moiety, said therapeutically active agent being selected from the group consisting of an anti-angiogenesis agent and an anti-cancer agent, and said polymeric backbone being comprised of a plurality of backbone units, wherein a portion of said backbone units have said angiogenesis targeting moiety attached thereto, the conjugate being represented by general Formula: [A 1 ]x [A 2 -B] y [A 3 -D] w wherein: A 1 , A 2 and A 3 are said backbone units covalently linked to one another and forming said polymeric backbone; B is said therapeutically active agent; D is said angiogenesis targeting moiety; x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 70.0 to 99.9; y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.01 to 15; and w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.01 to 15, such that [A 2 -B] is a backbone unit having attached thereto said therapeutically active agent; and [A 3 -D] is a backbone unit having attached thereto said angiogenesis targeting moiety, whereas each of the [A 1 ], the [A 2 -B] is either a terminal backbone unit being linked to one of said [A 1 ], the [A 2 -B] and the [A 3 -D], or is linked to at least two of said [A 1 ], said [A 2 -B] and said [A 3 -D]; and the [A 3 -D] is linked to at least two of said [A 1 ], said [A 2 -B] and said [A 3 -D].