Patent ID: 7253176

Claim:
An immunosuppressive composition in unit dosage form for immunosuppression incident to organ transplantation and xenogenic events comprising: a) a first immunosuppressive compound having general Formula (I), as follows: wherein R 1 , R 2 and R 3 are independently hydrogen, saturated or unsaturated, straight or branched C 1-6 aliphatic chains, X and Y are independently oxygen or sulfur, Z 1 is selected from the group consisting of an unsubstituted thienyl group and an unsubstituted furanyl group, and Z 2 is selected from the group consisting of a phenyl group; a sulfonic acid group; an unsubstituted sulfonamide group; a substituted sulfonamide group that is substituted with one of an alkyl group, an unsubstituted aminoalkyl group and a C 1-4 alkyl-substituted aminoalkyl group; an amino group; a halogen-substituted amino group; a C 1-3 aliphatic group; a halogen-substituted C 1-3 aliphatic group and a C 1-12 aliphatic group that is substituted with one or more functional groups selected from the group consisting of an ester group, an amide group, an unsubstituted amine group, a C 1-3 alkyl-substituted amine group and a sulfonamide group, or a pharmaceutically acceptable salt thereof in an amount effective to cause immunosuppression in a patient; and b) a pharmaceutically acceptable excipient.