Patent ID: 7264823

Claim:
A method comprising applying a moisture-curable, isocyanate-functional adhesive to tissue, the adhesive comprising the reaction product of a reaction mixture consisting essentially of: (a) a stoichiometric excess of an isocyanate reactant selected from the group consisting of lysine tri-isocyanate, lysine di-isocyanate, lysine di-isocyanate ethyl ester, and combinations thereof; and (b) a multi-functional reactant selected from the group consisting of a saccharide, a polysaccharide, a steroid, glycerol, ascorbic acid, an amino acid, and combinations thereof, the multi-functional reactant having at least two isocyanate-reactive functional groups, wherein the reaction product has an average isocyanate functionality of at least 2.1 and forms covalent bonds upon application to tissue.