Patent ID: 8367838

Claim:
A compound of formula I wherein R 1 is hydrogen, halogen or lower alkyl, R 2 is hydrogen, halogen or lower alkyl, R 3 is halogen or lower alkyl, which lower alkyl is optionally substituted by halogen, R 4 is a) lower alkyl, optionally substituted by halogen or lower alkoxy, b) lower alkoxy, optionally substituted by halogen, hydroxyl, cycloalkyl or heterocyclyl, c) —Si(lower alkyl) 3 , d) —O-cycloalkyl, optionally substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, e) —O-aryl, optionally substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, f) —O-heteroaryl, optionally substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, g) —O-heterocyclyl, optionally substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, wherein each S being part of a heterocyclyl is optionally substituted by oxo, h) heteroaryl, optionally substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, i) aryl, substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, or j) heterocyclyl, optionally substituted by halogen, amido, nitro, acetyl, acetamidyl, lower alkyl, halogen-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, halogen-lower alkoxy, —NR 11 R 12 , or —S(O) 2 -lower alkyl, and R 4 is hydrogen when R 10 is phenyl, wherein the phenyl is optionally substituted by halogen, lower alkyl, or —S(O) 2 -lower alkyl, and R 4 is aryl when R 6 is lower alkyl, R 5 is halogen or lower alkyl, R 6 is hydrogen or lower alkyl, R 7 is hydrogen or lower alkyl, R 8 is hydrogen or lower alkyl, R 9 is hydrogen, halogen, lower alkyl or lower alkoxy, R 10 is hydrogen, halogen, lower alkyl or lower alkoxy, R 11 is hydrogen or lower alkyl, R 12 is hydrogen or lower alkyl, X is a) N and Y is C—R 10 , or b) C—R 9 and Y is N, n is 0 or 1, with the proviso that R 8 is lower alkyl, when a) R 1 is hydrogen, R 2 is hydrogen, R 3 is chloro, R 4 is hydrogen, R 6 is methyl, R 7 is hydrogen, R 9 is hydrogen, n is 0, X is C—R 9 and Y is N; or b) R 1 is hydrogen, R 2 is hydrogen, R 3 is chloro, R 4 is hydrogen, R 6 is methyl, R 7 is hydrogen, R 10 is hydrogen, n is 0, X is N and Y is C—R 10 ; or a pharmaceutically active salt thereof.