Patent ID: 8277805

Claim:
A method for treatment of a thromboembolic disorder or for inhibition of coagulation, said method comprising administering an effective dose of an inhibitory antibody against Factor VIII or fragment thereof comprising the immunoglobulin variable light chain CDR1, CDR2 and CDR3 regions depicted in SEQ ID NO: 36, SEQ ID NO: 37 and SEQ ID NO: 38 respectively, and comprising the immunoglobulin variable heavy chain CDR1, CDR2 and CDR3 regions with SEQ ID NO: 33, SEQ ID NO: 34 and SEQ ID NO: 35 respectively, wherein the glycosylation site at positions 3 and/or 5 in the CDR1 region of the heavy chain is mutated, or wherein Asn at position 3 in the CDR1 region of the variable heavy chain is deglycosylated, and wherein said administering results in said treatment of said thromboembolic disorder or in said inhibition of coagulation.