Patent ID: 7635473

Claim:
A stable formulation, comprising: (a) a humanized version of monoclonal antibody 3D6 at a concentration of from about 1 mg/ml, to about 50 mg/ml, wherein the humanized 3D6 antibody comprises a light chain comprising the amino acid sequence of SEQ ID NO:1 and a heavy chain comprising the amino acid sequence of residues 1-448 of SEQ ID NO:2; (b) histidine at a concentration of from about 5 mM to about 15 mM; (c) mannitol in an amount of from about 2% w/v to about 6% w/v; (d) methionine at a concentration of from about 5 mM to about 15 mM; and (e) polysorbate in an amount of from about 0.001% w/v to about 0.01% w/v, wherein the formulation has a pH of from about 5.5 to about 6.5.