Patent ID: 8465933

Claim:
A method of screening for a human blood group A-compatible lactobacillus , comprising: (a) providing a candidate lactobacillus; (b) determining ability of the candidate lactobacillus to recognize a human blood group A antigen, a human blood group B antigen, and a human blood group H antigen, wherein the recognizing ability is determined by measuring response units (RU) of surface plasmon resonance spectrum, wherein the human blood group A antigen comprises [GalNAcα1-3(Fucα1-2)Gal-]; and (c) selecting the candidate lactobacillus as a human blood group A-compatible lactobacillus if: (i) blood group A antigen-recognizing ability is 2,000 RU or higher; (ii) blood group B antigen-recognizing ability is 100 RU or lower; (iii) blood group H antigen-recognizing ability is 100 RU or lower; (iv) ratio of the blood group A antigen-recognizing ability to the blood group B antigen-recognizing ability is 70 or higher; (v) ratio of the blood group A antigen-recognizing ability to the blood group H antigen-recognizing ability is 100 or higher; (vi) A-HCM-recognizing ability is 100 RU or higher; and (vii) O-HCM-recognizing ability is 100 RU or lower.