Patent ID: 7303886

Claim:
A method for identifying a compound that potentially modulates a T1R1/T1R3 receptor comprising: (i) screening one or more compounds in a functional assay that detects compounds which modulate (enhance or inhibit) the activity of the T1R1/T1R3 receptor by another compound; and (ii) identifying compounds that potentially modulate the T1R1/T1R3 receptor-based on their modulation (enhancement or inhibition) of the activity of the T1R1/T1R3 receptor by another compound, wherein said T1R1 is a T1R1 polypeptide and is (i) encoded by a nucleic acid sequence comprising SEQ. ID. NO: 8, (ii) encoded by a nucleic acid sequence comprising a nucleic acid that hybridizes to SEQ. ID. NO: 8 under stringent hybridization conditions which are conducting the hybridization reaction at 42° C. in a solution comprising 50% formamide, 5×SSC, and 1% SDS and washing at 65° C. in a solution comprising 0.2×SSC and 0.1% SDS, or (iii) a T1R1 polypeptide possessing at least 95% sequence identity to the T1R1 polypeptide of SEQ. ID. NO: 5; wherein said T1R3 is a T1R3 polypeptide and is (i) encoded by a nucleic acid sequence comprising SEQ. ID. NO: 9; (ii) encoded by a nucleic acid sequence that hybridizes to SEQ. ID. NO: 9; under stringent hybridization conditions which are conducting the hybridization reaction at 42° C. in a solution comprising 50% formamide, 5×SSC, 10% SDS; and washing at 65° C. in a solution comprising 0.2×SCC and 0.1% SDS, or (iii) a T1R3 polypeptide possessing at least 95% sequence identity to the T1R3 polypeptide of SEQ. ID. NO: 7; and wherein said T1R1/T1R3 receptor comprised of at least one endogenous T1R1 polypeptide and at least on endogenous T1R3 polypeptide.