Patent ID: 7049289

Claim:
A compound of formula: Y—(CR 2 ) n X—NHJ where: X is C═O or CR 2 ; n is an integer of value 1 to 6; Y is R 1 R 2 CR— where one of R 1 and R 2 is —NH(B) p Z 1 and the other is —CO(B) q Z 2 where p and q are integers of value 0 to 30, and each B is independently chosen from Q or an amino acid residue, where Q is a cyclic peptide; Z 1 and Z 2 are metal complexing agents (L) or other protecting groups, which are biocompatible groups which inhibit or suppress in vivo metabolism of the peptide; J and each R are independently chosen from H, C 1-4 alkyl, C 1-4 alkenyl, C 1-4 alkynyl, C 1-4 alkoxyalkyl or C 1-4 hydroxyalkyl; with the proviso that: (i) when X is CR 2 , then Z 2 is a metal complexing agent (L); (ii) at least one of R 1 and R 2 bears at least one detectable moiety suitable for diagnostic imaging of the human body; (iii) R 1 and R 2 include one or more of the peptide sequence consisting of NQEQVSPYTLLKG (SEQ ID NO: 2), which is a peptide fragment of α 2 -antiplasmin.