Patent ID: 7935699

Claim:
A compound of the formula (I): wherein: R 1 and R 2 are, independently, hydrogen, halogen, amino, hydroxyamino, cyano, nitro, lower alkyl, —OR 5 , —C(O)OR 6 , perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfinyl, lower alkyl sulfonyl, cycloloweralkyl sulfonyl, lower alkoxy lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl or sulfonamido; or R 1 and R 2 , together with the phenyl ring to which they are attached, combine to form a 2,3-dihydro-benzo[b]thiophene, 2,3-dihydro-benzo[b]thiophene 1-oxide, 2,3-dihydro-benzo[b]thiophene 1,1-dioxide, benzo[b]thiophene, benzo[b]thiophene 1-oxide, benzo[b]thiophene 1,1-dioxide, thiochroman, thiochroman 1-oxide or thiochroman 1,1-dioxide group; R 3 is a cycloalkyl, a bicycloalkyl or a mono- or bicyclic heterocycle with 1-3 hetero atoms selected from N, O and S, said cycloalkyl or heterocycle being unsubstituted or mono-, bi- or trisubstituted with halogen, lower alkyl, lower alkyoxy, carbonyl or lower alkyl sulfonyl; R 4 is hydrogen, or alkyl having 1 to 10 carbon atoms; R 5 is hydrogen, alkyl having from 1 to 6 carbons, phenyl, benzyl, substituted phenyl or substituted benzyl; R 6 is hydrogen, alkyl having from 1 to 6 carbons, benzyl or substituted benzyl; R 7 is hydrogen, hydroxy, alkoxy, perfluoroalkoxy, amino, alkyl amino, or dialkylamino, methylene hydroxy, C(O)OY′, where Y′ is H or lower alkyl; R 8 is hydrogen or lower alkyl; R 9 is hydrogen, cycloalkyl or lower alkyl; R 10 is hydroxy, lower alkoxy, amino, methylamino, dimethylamino or —NH 2 CH 2 -cycloalkyl; R 11 is hydroxy, amide, amide-loweralkyl, cyclopropyl methyl amide, methoxy, NHCH 2 CH 2 CH 2 L, wherein L is methoxy, hydroxy or dimethylamino; R 12 is hydrogen or lower alkyl; R 13 is hydrogen or lower alkyl; R 14 is hydrogen, lower alkyl, SO 2 X′, wherein X′ is lower alkyl, or C(O)Y″, where Y″ is lower alkyl or O-alkyl; R 15 is hydroxy, methoxy, t-butoxy, lower alkyl, 2-hydroxy-2-methyl-propyl, amino, methylamino, propylamino, dimethylamino, diethylamino, morpholino, anilino, benzylamino, allylcarbamoyl-lower alkyl, allylamino, pyrazin-2-ylamino, and NH—(CH 2 ) v Z, wherein Z is methoxy or morpholino; R 16 is lower alkyl; R 17 is methoxy; R 18 is H, lower alkyl, C(O)R where R is lower alkyl; X, Y are, independently, hydrogen, halogen, cyano, lower alkyl, methoxy, SO 2 X″ where X″ is alkyl, or cycloalkyl m is 0, 1, 2, 3 or 4; wherein if m=0 R 7 can not be hydroxy, alkoxy, perfluoroalkoxy, amino, alkyl amino, or dialkylamino; n is 0, 1, 2; p is 0, 1; q is 0, 1, 2; v is 2, 3; and wherein if R 3 is tetrahydropyran, then R 2 is not hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.