Patent ID: 7482351

Claim:
A compound according to structural formula (I): or a salt, N- or S-oxide therof, wherein: R 2 is selected from hydroxy, lower alkoxy optionally substituted with one or more of the same or different R d groups, C 5 -C 14 aryloxy optionally substituted with one or more of the same or different R d groups, a lower alkyl-, aryl- or arylalkyl-sulfonate optionally substituted with one or more of the same or different R d groups, C 5 -C 14 aryl optionally substituted with one or more of the same or different R d groups, C 6 -C 20 arylalkyl optionally substituted with one or more of the same or different R d groups, 5-14-membered heteroaryl optionally substituted with one or more of the same or different R d groups and 6-20 membered heteroarylalkyl optionally substituted with one or more of the same or different R d groups; R 4′ is a lower alkyl optionally substituted with one or more of the same or different R e groups; R 5 is —C(O)R a , —C(O)OR a , —C(O)NR c R c , —CH 2 OH, halo, nitro, cyano, or trifluoromethyl; R 8 is selected from hydrogen and halo; R 9 is selected from hydroxy, lower alkoxy optionally substituted with one or more of the same or different R e groups, trifluoromethoxy and halo, or, alternatively, R 9 is taken together with R 10 to form a heteroalkylene bridge of the formula —O—(CR a R a ) n —O—, where n is 1, 2 or 3; R 10 is selected from lower alkyl, lower alkoxy and halo or, alternatively, R 10 is taken together with R 9 to form a heteroalkylene bridge of the formula —O—(CR a R a ) n —O—, where n is 1, 2 or 3; each R a is, independently of the others, selected from hydrogen and lower alkyl; each R c is, independently of the other, selected from hydrogen and lower alkyl, or alternatively, two R c groups bonded to the same nitrogen atom may be taken together with that atom to form a 5 to 7-membered heterocyclic ring that may optionally include from 1 to 4 of the same or different additional heteroatoms selected from O, N and S, and which may further optionally include a lower alkyl substituent at one or more available carbon and/or nitrogen atoms; each R d is, independently of the others, selected from a water-solubilizing group, hydroxy, lower alkoxy, and —C(O)R a and —(CH 2 ) m NR c R c , where m is 0, 1, 2 or 3; and R e is selected from —NR c R c , —C(O)OR a and —C(O)NR c R c , wherein the water-solubilizing group is selected from CH and N and Z is selected from CH 2 , O, S, NH, N—(CH 2 ) y —R a , N—(CH 2 ) y —C(O)R a , N—(CH 2 ) y —C(O)OR a , N—(CH 2 ) y —S(O) 2 R a , N—CH 2 —S(O) 2 OR a and N—(CH 2 ) y —C(O)NR c R c , provided that Y and Z are not both simultaneously CH and CH 2, respectively, and y is an integer from 0 to 6.