Patent ID: 8404708

Claim:
A method of treating schizophrenia comprising administering to an individual an effective amount of a compound of formula IE wherein R 1 is phenyl, unsubstituted or substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, —(CH 2 ) d OH, —C(O)H, CF 3 , CN, S-alkyl, —S(O) b -alkyl, —C(O)NR′R″, —NR′C(O)-alkyl and —NR′S(O) 2 -alkyl; R 2 and R 3 are each independently hydrogen, halogen, alkyl, alkoxy, OCHF 2 , OCH 2 F, OCF 3 or CF 3 ; R 4 and R 5 form together with the N-atom to which they are attached a ring with —(CH 2 ) c —NR′—(CH 2 ) 2 -, which is unsubstituted or substituted by one or more substituents selected from the group consisting of lower alkyl, halogen, —(CR′R″) d OH, ═O, and —NR′R″, wherein R′ and R″ together with the N-atom to which they are attached form a ring with —(CH 2 ) e , or by —(CH 2 ) d NR′—C(O)-alkyl, —(CH 2 ) d —C(O)-alkyl, —(CH 2 ) d —C(O)-cycloalkyl, —(CH 2 ) d OC(O)NR′R″, —(CH 2 ) d —S(O) 2 -alkyl, —(CH 2 ) d -pyrrolidinyl or —C(O)NR′R″; R′ is hydrogen, alkyl, —(CH 2 ) d OH, —C(O)H, —C(O)-alkyl, —C(O) -cycloalkyl, —S(O) 2 -alkyl, —S(O) 2 -halogen-alkyl, —S(O)-alkyl, —S-alkyl or —S(O) 2 —N-di-alkyl; R″ is hydrogen or alkyl; b is 1 or 2; c is 2, or 3; d is 0, 1, 2, or 3; and e is 3, 4, or 5; or a pharmaceutically active acid-addition salt thereof.