Patent ID: 8440708

Claim:
A compound of formula I: or pharmaceutically acceptable salts thereof, wherein: R 1 is [1,2,4]triazol-1-yl substituted once with C 1-6 alkyl, halo-C 1-6 alkyl, hetero-C 1-6 alkyl, C 3-6 -cycloalkyl, C 3-6 cycloalkyl-C 1-6 alkyl or cyano; R 2 is phenyl substituted once or twice with halo or methyl, or pyridin-2-yl substituted with methyl or halo at the 5-position; R 3 is: hydrogen; C 1-6 alkyl; hetero-C 1-6 alkyl; or cyano; R 4 is: hydrogen; C 1-6 alkyl; or hetero-C 1-6 alkyl; or R 3 and R 4 together with the atom to which they are attached may form a C 3-6 carbocyclic ring; R 5 is: C 1 -6alkyloxy-C 1-6 alkyl; hydroxy-C 1 -6alkyl; hetero cyclyl-C 1-6 alkyl; or hetero aryl selected from pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl or thiazolyl, wherein each of said heteroaryl is substituted once or twice with a group or groups independently selected from methyl, ethyl, n-propyl, fluoro, chloro, amino, methylamino or dimethylamino; or R 4 and R 5 together with the atom to which they are attached may form a C 3-6 carbocyclic ring that is optionally substituted with hydroxy; or R 4 and R 5 together with the atom to which they are attached may form a C 4-6 heterocyclic ring containing one or two heteroatoms each independently selected from O, N and S; or R 3 , R 4 and R 5 together with the atom to which they are attached may form a six-membered heteroaryl containing one or two nitrogen atoms, and which is optionally substituted with halo, amino or C 1-6 alkyl; R 6 is: hydrogen; C 1-6 alkyl; C 1-6 alkyloxy; halo; C 1-6 haloalkyl; or cyano; and one or both of R 7 and R 8 is: hydrogen; C 1-6 alkyl; C 1-6 alkyloxy; halo; C 1-6 haloalkyl; or cyano.