Patent ID: 6979671

Claim:
A cyclosporin analog of formula (1), or pharmaceutically acceptable salt: wherein, A is of the formula: wherein X is absent, —C 1 ,-C 6 alkyl-, or —C 3 -C 6 cycloalkyl- Y is selected from the group consisting of: (i) C(O)—O—R 1 , where R 1 -is C 1 -C 6 alkyl substituted with halogen, heterocyclic, aryl, C 1 -C 6 -alkoxy, C 1 -C 6 alkylthio, halogen-substituted C 1 -C 6 alkoxy, or halogen-substituted C 1 -C 6 alkylthio; (ii) C(O)—S—R 1 ; (iii) C(O)—OCH 2 —OC(O)R 2 , where R 2 is C 1 -C 6 alkyl optionally substituted with halogen, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, heterocyclic or aryl; (iv) C(S)—O—R 1 ; and (v) C(S)—S—R 1 ; B is -αAbu-, -Val-, -Thr- or -Nva-; and U is —(D)Ala-, -(D)Ser-, —[O-(2-hydroxyethyl)(D)Ser]—, —[O-acyl(D)Ser]— or—[O-(2-acyloxyethyl)(D)Ser]-.