Patent ID: 7326682

Claim:
An isolated, synthetic or recombinant χ-conotoxin peptide having the activity of inhibiting a neuronal amine transporter, wherein said χ-conotoxin peptide comprises the sequence represented by SEQ ID NO: 1 (NGVCCGYKLCHOC) or a derivative thereof, wherein “O” represents 4-hydroxyproline, and wherein said derivative peptide sequence comprises an Asn, Gln, Asp, or Glu at position 1 of SEQ ID NO:1; a Gly, Ser, Thr, Pro, Hyp, or Ala at position 2 of SEQ ID NO:1; a Val, Ile, or Leu at position 3 of SEQ ID NO:1; a Gly, Ser, Thr, Pro, Hyp, or Ala at position 6 ; of SEQ ID NO:1; a Tyr, Phe, or Trp at position 7 of SEQ ID NO:1; a Lys, His, Arg, ornithine, homoarginine, or dimethyllysine at position 8 of SEQ ID NO:1; a Leu, Val, or Ile at position 9 of SEQ ID NO:1; a His, Lys, Arg, ornithine, homoarginine, or dimethyllysine at position 11 of SEQ ID NO:1; and 4-hydroxyproline, Pro, Ser, Thr, Gly, or Ala at position 12 of SEQ ID NO:1.