Patent ID: 7449315

Claim:
A compound of the formula: wherein: R 1 and R 2 are individually selected from the group consisting of H, CH 3 , C 2 -C 10 alkyls, C 2 -C 10 alkenyls or C 2 -C 10 alkynyls, straight or branched; C 2 -C 10 heteroalkyls, C 2 -C 10 heteroalkenyls or C 2 -C 10 heteroalkynyls and —(CR 15 R 16 ) p -D; wherein: R 15 and R 16 are individually selected from the group consisting of H, CH 3 , C 2 -C 10 alkyls, C 2 -C 10 alkenyls or C 2 -C 10 alkynyls, straight or branched; and C 2 -C 10 heteroalkyls, C 2 -C 10 heteroalkenyls or C 2 -C 10 heteroalkynyls; p is a positive integer from 1 to about 12; D is selected from the group consisting of —SH, —OH, X 2 , —CN, —OR 19 , NHR 20 , wherein: R 17 is H, CH 3 or X 3 ; R 18 is H, a C 1-4 alkyl or benzyl; R 19 is H, a C 1-4 alkyl, X 2 or benzyl; R 20 is H, a C 1-10 alkyl or —C(O)R 21 , wherein R 21 is H, a C 1-4 alkyl or alkoxy, t-butoxy or benzyloxy; X 2 and X 3 are independently selected halogens; R 3 is H, CH 3 , or —C(═O)(CR 15 R 16 ) w -D, where w is 0 or an integer from 1 to about 12, and D is H or as described for R 1 and R 2 ; J is O, NH or S; R 4 , R 5 , and R 6 are independently selected from the group consisting of H, CH 3 , C 2 -C 10 alkyls, C 2 -C 10 alkenyls or C 2 -C 10 alkynyls, straight or branched; C 2 -C 10 heteroalkyls, heteroalkenyls or heteroalkynyls and halogens; Z is NR 7 R 8 or wherein R 7 is selected from the group consisting of H, CH 3 , C 2 -C 10 alkyls, alkenyls or alkynyls straight or branched; C 2 -C 10 heteroalkyls, heteroalkenyls or heteroalkynyls, or —(CR 23 R 24 ) q -aryl, or R 8 , wherein R 23 and R 24 are independently selected from the group consisting of H and C 1 -C 10 alkyls; q is an integer from 1 to about 6; R 8 is selected from the group consisting of (CR 9 R 10 ) n -NR 22 -R 11 , (CR 9 R 10 ) n -CH 2 -NHC(O)R 26 and (CR 9 R 10 ) n -CH 2 -E; wherein R 9 and R 10 are independently selected from the group consisting of H, CH 3 , C 2 -C 10 alkyls, C 2 -C 10 alkenyls or C 2 -C 10 alkynyls, straight or branched; C 2 -C 10 heteroalkyls, C 2 -C 10 heteroalkenyls or C 2 -C 10 heteroalkynyls and halogens; R 26 is H, CH 3 , O-t-butyl, O-benzyl; E is OH, SH or O—C(O)R 27 , wherein R 27 is a C 1 -C 6 alkyl, benzyl or phenyl; R 22 is H or CH 3 ; n is a positive integer from 1 to about 10; R 11 is H or-L-B, wherein L is a positive linker covalently linking NR 22 to B; and B is selected from the group consisting of polymers, biologically active materials and polymeric supports; R 25 is H, —C(O)—R 28 or —C(O)—O—R 29 , wherein R 28 is a C 1 -C 6 alkyl or benzyl; and R 29 is CH 3 , t-butyl or benzyl; X 1 is O, NH, or S; and A is A 2 wherein X 1 A 2 is an enzyme, or a pharmaceutical salt thereof.