Patent ID: 7462716

Claim:
A compound of general formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof wherein: X is —O—, —S—, —NH— or —NHR 1 —, R 1 being straight or branched alkyl with 1 to 10 carbon atoms, preferably CH 3 ; R is a stating residue of formula Y is a bivalent radical having the following meaning: a) straight or branched C 1 -C 20 alkylene being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxyl, —ONO 2 or T 0 , wherein T 0 is —OC(O)(C 1 -C 10 alkyl)-ONO 2 or —O(C 1 -C 10 alkyl)-ONO 2 ; cycloalkylene with 5 to 7 carbon atoms in the cycloalkylene ring, the ring being optionally substituted with side chains T, wherein T is straight or branched alkyl with from 1 to 10 carbon atoms; b) c) wherein n is an integer from 0 to 20, and n 1 is an integer from 1 to 20; d) wherein: n 1 is as defined above and n 2 is an integer from 0 to 2; X 1 =—OCO— or —COO— and R 2 is H or CH 3 ; e) wherein: n 1 , n 2 , R 2 and X 1 are as defined above; Y 1 is —CH 2 —CH 2 — or —CH═CH—(CH 2 ) n 2 ; f) wherein: n 1 and R 2 are as defined above, R 3 is H or COCH 3 ; with the proviso that when Y is selected from bivalent radicals mentioned under b)-f), the —ONO 2 group is bound to —(CH 2 ) n 1 ; g) wherein X 2 is —O— or —S—, n 3 is an integer from 1 to 6, R 2 is as defined above; h) wherein: n 4 is an integer from 0 to 10; n 5 is an integer from 1 to 10; R 4 , R 5 , R 6 , R 7 are the same or different, and are H or straight or branched C 1 -C 4 -alkyl; wherein the —ONO 2 group is bound to n 5 being as defined above; Y 2 is a 5 or 6 member saturated, unsaturated or aromatic heterocyclic ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulphur.