Patent ID: 7678781

Claim:
A compound of formula (I) wherein n is an integer from 0 to 3; R 0 is selected from the group consisting of hydroxy, halogen, C 1-3 alkyl, C 1-3 alkoxy, cyano, nitro, amino, (C 1-4 alkylamino) and di(C 1-4 alkyl)amino; X is selected from the group consisting of O and S; R 1 and R 2 are each independently selected from the group consisting of hydroxy, C 1-4 alkyl, —CH(—O—C 1-4 alkyl) 2, C 1-4 alkoxy, halogenated C 1-4 alkyl, halogenated C 1-4 alkoxy, phenyl, —O-phenyl, —O-aralkyl and NR 5 R 6; wherein the phenyl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from hydroxy, carboxy, halogen, C 1-3 alkyl, C 1-3 alkoxy, cyano, nitro, amino, (C 1-4 alkylamino) and di(C 1-4 alkyl)amino; wherein R 5 and R 6 are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; alternatively, R 5 and R 6 are taken together with the nitrogen atom to which they are bound to form a 5- to 7- membered saturated or partially unsaturated nitrogen containing heterocyclyl ring; wherein the nitrogen containing heterocyclyl ring is optionally substituted with one or more substituents independently selected from hydroxy, carboxy, C 1-4 alkyl, C 1-4 alkoxy, nitro, cyano, amino, (C 1-4 alkylamino) and di(C 1-4 alkyl)amino; alternatively, R 1 and R 2 are taken together with the phoshorous atom to which they are bound to form a 5- to 7- membered saturated phosphorous containing heterocyclyl ring; wherein the phosphorous containing heterocyclyl ring is optionally substituted with one or more substituents independently selected from hydroxy, carboxy, C 1-4 alkyl, C 1-4 alkoxy, nitro, cyano, amino, (C 1-4 alkylamino) and di(C 1-4 alkyl)amino; R 3 is selected from the group consisting of—OH and —O—C(O)—C 1-4 alkyl, —O—C 1-4 alkyl and —O-benzyl; R 4 is selected from the group consisting of hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, —C 1-4 alkyl-CN, halogenated C 1-4 alkyl, —C 1-4 alkyl-phenyl, —C 2-4 alkenyl-phenyl and —C 2-4 alkynyl-phenyl; alternatively, R 3 and R 4 are taken together with the carbon atom to which they are bound to form C(═O) or a 5- to 7-membered oxygen containing, saturated or partially unsaturated ring structure; wherein the oxygen containing ring structure is further optionally substituted with one or more substituents independently selected from the group consisting of hydroxy, carboxy, C 1-4 alkyl,C 1-4 alkoxy, ═CH 2 , nitro, cyano, amino, (C 1-4 alkylamino) and di(C 1-4 alkyl)amino; or a pharmaceutically acceptable salt, ester or prodrug thereof.