Patent ID: 8063085

Claim:
Compounds of formula I: wherein: R1 is selected from the group consisting of halogen and lower alkynyl; R2 is selected from the group consisting of hydrogen and fluorine; R3 and R4 are independently selected from the group consisting of hydrogen, halogen, and lower alkyl; R5 is selected from the group consisting of hydrogen, chlorine, and lower alkyl; R6 is selected from the group consisting of optionally substituted aryl, C3 to C7 cycloalkyl, —(CH 2 ) n —C3 to C7 cycloalkyl, —(CH 2 ) n -lower alkynyl, and —(CH 2 ) m CO—X, wherein X is a member selected from the group consisting of lower alkoxy, hydroxy, and NH—O—(CH 2 ) 2 —OH, each n is independently 0, 1, or 2 and m is 1 or 2; R7 is selected from the group consisting of hydrogen and wherein R8 is selected from the group consisting of hydrogen, lower alkyl, C3 to C6 cycloalkyl, lower alkoxy, optionally substituted benzyl, optionally substituted aryl, and optionally substituted heteroaryl; R9 and R10 are independently selected from the group consisting of hydrogen and lower alkyl; or R9 and R10, together with the carbon to which they are attached, can form a C3 to C7 cycloalkyl group and R8 is hydrogen; and pharmaceutically acceptable salts or esters thereof.