Patent ID: 7399782

Claim:
A method of reducing the severity of or delaying the onset of symptoms associated with cystic fibrosis or asthma in a subject comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound of Formula X, or a pharmaceutically acceptable salt, where Formula X is: wherein A is R is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 6 alkyl ester, C 2 -C 6 alkenyl ester, amino, amido, aryl ester, cycloalkyl ester, cycloalkenyl ester, purinyl, pyrimidinyl, heterocyclyl, aryl, or heteroaryl; R 1 is H or —(CO)CH 3 ; and R 2 and R 3 at each occurrence are independently —CH 2 (CO)CH 3 , —CH 2 (CO)CH 2 CH 3 , —CH 2 (CO)CH(CH 3 ) 2 , —CH 2 (CO)CH 2 CH 2 CH 3 , —CH 2 (CO)CH(CH 3 )CH 2 CH 3 , or —CH 2 (CO)CH 2 CH(CH 3 ) 2 , or OR 2 and OR 3 can be taken together to form a six membered ring of the formula (Ia) wherein X is CH, C═O, or CH(CH 3 ); wherein the bracketed-dashed bonds indicate attachment to backbone; Y is CH═CH, C═O, CHCH 3 , or CH 2 ; n is 1 or 0.