Patent ID: 8257916

Claim:
A method for detecting integrated HPV DNA, comprising: obtaining a first sample comprising DNA derived from a cell of a subject; obtaining a second sample comprising DNA derived from the cell, wherein the DNA in the second sample is treated with an enzyme which has exonuclease activity; obtaining a first information related to an amount of HPV DNA in the first sample, wherein the first information comprises information related to an amount of both episomal HPV DNA and integrated HPV DNA; obtaining a second information related to amount of an HPV DNA in the second sample, wherein the second information comprises information related to an amount of episomal HPV DNA, and does not substantially comprise information related to an amount of integrated HPV DNA; and detecting the integrated HPV DNA in the cell based on the first and second information; wherein the detecting is performed by determining that the integrated HPV DNA is contained in the cell if the total amount of HPV DNA in the first sample is larger than the total amount of HPV DNA in the second sample.