Patent ID: 8067535

Claim:
A method for inducing a T cell immune response against a vaccinia and/or variola virus antigen in an individual, wherein said vaccinia and/or variola virus antigen comprises a T cell epitope that is identical or has substantial homology to peptide B7080 (SEQ ID NO: 35), comprising administering to said individual a composition consisting essentially of one or more isolated peptides selected from the group consisting of: peptide B7080 (SEQ ID NO: 35) and one or more homologues of peptide B7080, and, optionally an adjuvant, wherein 1 to 4 amino acids of SEQ ID NO: 35 are substituted in the one or more homologues of peptide B7080, and the one or more homologues of peptide B7080 are the same length as SEQ ID NO: 35 and maintain the function of SEQ ID NO: 35 as a CD8 T cell epitope of the vaccinia or variola virus; whereby a T cell immune response is induced against the vaccinia and/or variola virus antigen in said individual.