Patent ID: 7115754

Claim:
A pyrrolidine derivative of Formula I: a geometrical isomer thereof, an optically active form thereof, an enantiomer thereof, a diastereomer thereof, one or more mixtures thereof, a racemate form thereof, or a salt thereof, wherein: R 1 is selected from the group consisting of H and C 1 –C 6 -alkyl; R 2 is selected from the group consisting of hydrogen, C 1 –C 6 -alkyl, C 1 –C 6 -alkyl aryl, heteroaryl, C 1 –C 6 -alkyl heteroaryl, C 2 –C 6 -alkenyl, C 2 –C 6 -alkenyl aryl, C 2 –C 6 -alkenyl heteroaryl, C 2 –C 6 -alkynyl, C 2 –C 6 -alkynyl aryl, C 2 –C 6 -alkynyl heteroaryl, C 3 –C 8 -cycloalkyl, heterocycloalkyl, C 1 –C 6 -alkyl cycloalkyl, C 1 –C 6 -alkyl heterocycloalkyl, C 1 –C 6 -alkyl carboxy, acyl, C 1 –C 6 -alkyl acyl, C 1 –C 6 -alkyl acyloxy, C 1 –C 6 -alkyl alkoxy, alkoxycarbonyl, C 1 –C 6 -alkyl alkoxycarbonyl, aminocarbonyl, C 1 –C 6 -alkyl aminocarbonyl, C 1 –C 6 -alkyl acylamino, C 1 –C 6 -alkyl ureido, amino, C 1 –C 6 -alkyl amino, sulfonyloxy, C 1 –C 6 -alkyl sulfonyloxy, sulfonyl, C 1 –C 6 -alkyl sulfonyl, sulfinyl, C 1 –C 6 -alkyl sulfinyl, C 1 –C 6 -alkyl sulfanyl, and C 1 –C 6 -alkyl sulfonylamino; R 3 is selected from the group consisting of aryl and heteroaryl; X is selected from the group consisting of O and NR 4 ; R 4 is selected from the group consisting of H, C 1 –C 6 -alkyl, C 1 –C 6 -alkyl aryl, C 1 –C 6 -alkyl heteroaryl, aryl and heteroaryl; wherein R 2 and R 4 can form together with the N atom to which they are linked to, a 5–8 membered saturated or unsaturated heterocycloalkyl ring; and n is an integer from 1 to 3.