Patent ID: 7378445

Claim:
A method to facilitate amelioration of the effects of symptoms or reduce the adverse effects of a carcinoma of the bladder or potentiate the immune system components therein to ameliorate the symptoms caused or facilitated by carcinoma of the bladder in a subject, said method comprising administrating to a subject having a carcinoma of the bladder a symptom-ameliorating effective amount of a chemical agent, which chemical agent is an ingenane, said ingenane having the formula: or pharmaceutically acceptable salts thereof, wherein: R 24 , R 25 and R 26 are independently selected from hydrogen, R 27 , R 28 , F, Cl, Br, I, OH, CN, OR 27 , SR 27 , NR 27 R 28 , N(═O) 2 , NR 27 OR 28 , ONR 27 R 28 , SOR 27 , SO 2 R 27 , SO 3 R 27 , SONR 27 R 28 , SO 2 NR 27 R 28 , SO 3 NR 27 R 28 , P(R 27 ) 3 , P(═O)(R 27 ) 3 , Si(R 27 ) 3 , B(R 27 ) 2 , (C═X)R 29 or X(C═X)R 29 where X is selected from sulfur, oxygen and nitrogen; R 27 and R 28 are each independently selected from C 1 -C 20 alkyl (branched and/or straight chained), aryl C 1 -C 20 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 14 aryl, C 1 -C 14 heteroaryl, C 1 -C 14 heterocycle, C 2 -C 10 alkenyl (branched and/or straight chained), C 2 -C 10 alkynyl (branched and/or straight chained), C 1 -C 10 heteroarylalkyl, C 1 -C 10 alkoxyalkyl, C 1 -C 10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C 1 -C 10 alkyl which is unsubstituted or substituted by CN, OR 30 , SR 30 , NR 30 R 31 , N═(O) 2 , NR 30 OR 31 , ONR 30 R 31 , SOR 30 , SO 2 R 30 SO 3 R 30 , SONR 30 R 31 , SO 2 NR 30 R 31 , SO 3 NR 30 R 31 , P(R 30 ) 3 , P═(O)(R 30 ) 3 , Si(R 30 ) 3 , and B(R 30 ) 2 ; R 29 is selected from R 27 , R 28 , CN, COR 27 , CO 2 R 27 , OR 27 , SR 27 , NR 27 R 28 , N(═O) 2 , NR 27 OR 28 , ONR 27 R 28 , SOR 27 , SO 2 R 27 , SO 3 R 27 , SONR 27 R 28 , SO 2 NR 27 R 28 , SO 3 NR 27 R 28 , P(R 27 ) 3 , P(═O)(R 27 ) 3 , Si(R 27 ) 3 , and B(R 27 ) 2 SO 3 NR 27 R 28 , P(R 27 ) 3 , P(═O)(R 27 ) 3 , Si(R 27 ) 3 , and B(R 27 ) 2 ; and each R 30 and R 31 are independently C 1 -C 20 alkyl, C 1 -C 20 aryl C 1 -C 2 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 14 aryl, C 1 -C 14 heteroaryl, C 1 -C 14 -heterocycle, C 2 -C 10 alkynyl, C 2 -C 10 alkenyl, C 1 -C 10 heteroarylalkyl, C 1 -C 10 alkoxyalkyl, C 1 -C 10 haloalkyl, dihaloalkyl, trihaloalkyl, or haloalkoxy.