Patent ID: 7847119

Claim:
A compound having the formula Y-A-Z, wherein: A is a phenyl group; ring A is unsubstituted or substituted with 1 to 4 substituents selected from lower alkyl, aryl, heteroaryl, hydroxy-(lower alkyl), amino-(lower alkyl), N-(lower alkyl)amino-(lower alkyl), N,N-di(lower alkyl)amino-(lower alkyl), N-arylamino-(lower alkyl), N,N-diarylamino-(lower alkyl), N-(heteroaryl)amino-(lower alkyl), N,N-di(heteroaryl)amino-(lower alkyl), hydroxylamino, O-(lower alkoxy)amino, O-aryloxyamino, O-heteroaryloxyamino, fluoro, chloro, bromo, nitro, hydroxyl, lower alkoxy, aryloxy, hydroxycarbonyl, lower alkanoyl, lower alkanoyloxy, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, formylamino, N-acylamino, N,N-diacylamino, hydrazido, N-(lower alkyl)hydrazido, N,N-di(lower alkyl)hydrazido, N-arylhydrazido, N,N-diarylhydrazido, N-(heteroaryl)hydrozido, N,N-di(heteroaryl)hydrazido, carbamoyl, N-(lower alkyl)carbamoyl, N,N-(lower alkyl)carbamoyl, N-arylcarbamoyl, N,N-diarylcarbamoyl, N-heteroarylcarbamoyl, N,N-di(heteroaryl)carbamoyl, hydroxysulfonyl, (lower alkoxy)sulfonyl, aryoxysulfonyl, heroaryloxysulfonyl, hydroxysulfonyl-(lower alkyl), (lower alkoxy)sulfonyl-(lower alkyl), aryoxysulfonyl-(lower alkyl), heroaryloxysulfonyl-(lower alkyl), (lower alkane)sulfonyl, arenesulfonyl, or heteroarenesulfonyl; Y and Z are substituents at adjacent positions on ring A; Y represents: Z represents: X represents O or S; R 1 , R 2 , R 3 and R 4 independently represent H, lower alkyl or lower alkoxy, wherein the lower alkyl and lower alkoxy groups are unsubstituted or substituted with groups independently selected from aryl, heteroaryl or fluoro, wherein R 1 and R 2 or R 3 and R 4 are optionally connected to form a 3 to 8 member ring, wherein the 3 to 8 member ring is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, or heteroaryl; each of a and b independently represents 0 or 1; a+b equals 1 or 2; G is a metal ion, a quaternary ammonium ion, or comprised of a pharmaceutically active chemical compound or the precursor thereof, wherein said pharmaceutically active chemical compound or precursor thereof possesses at least one nucleophilic group prior to becoming G; or X-G represents a carbonyl-activating group selected from the group consisting of hydroxybenzotriazole-1-oxy, succinimide-N-oxy, p-nitrophenyloxy and pentafluorophenyloxy radical; J is lower alkyl, aryl, heteroaryl, omega-hydroxycarbonyl-(lower alkyl), omega-(lower alkoxy)carbonyl-(lower alkyl), or comprised of a specific binding agent, wherein a specific binding agent is a protein, peptide, lectin, saccharide, or other moiety that selectively binds to a molecule on the surface of a cell; or omega-(X-G)-carbonyl-(lower alkyl) group, wherein X-G is a carbonyl-activating group defined above.