Patent ID: 7482456

Claim:
A compound represented by Formula (I): or a pharmaceutically acceptable salt, wherein S 1 , S 2 , and S 3 are independently 1. H, 2. —OH, 3. halogen, 4. —C 1 -C 6 alkyl, 5. —O—C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 halogens, or —CN; R 1 is 1. —(C 1 -C 6 alkyl)-SO n —(C 1 -C 6 alkyl) group, optionally substituted with 1, 2 or 3 substituents; wherein each substituent is independently a halogen, —OH and —CN, 2. —C(O)—O-aryl, 3. —C(O)—NH-aryl, 4. —C(O)—NH-heterocycle or N-oxide thereof, 5. —C(O)—NH—C 1 -C 6 alkyl, 6. —C(O)—NH-cycloC 3 -C 6 alkyl, 7. —C 1 -C 6 alkyl, optionally substituted with 1 to 6 halogens and 1 hydroxy, 8. —COOH, 9. —C 1 -C 6 alkyl-COOH, 10. —O—C 1 -C 6 alkyl, 11. -cycloC 3 -C 6 alkyl, 12. —C 3 -C 6 alkyl-heterocycle, 13. aryl, 14. heterocycle, 15. carbonyl, 16. carbamoyl, or 17. —SO n —(C 1 -C 6 alkyl); each n is independently 0, 1, or 2; Ar 1 and Ar 2 are each independently an aryl or heterocycle or an N-oxide thereof; R 2 is 1. Hydrogen, 2. aryl optionally substituted with 1, 2 or 3 substituents selected from halogen, 3. heterocycle optionally substituted with 1, 2 or 3 halogens, 4. —C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 substituents selected from hydroxy and halogen, 5. —COOH, 6. 1, 2 or 3 halogens, 7. —SO n —(C 1 -C 6 alkyl), 8. —N(H)—S(O) n —C 1 -C 6 alkyl, 9. —O—C 1 -C 6 alkyl substituents each optionally substituted with 1, 2 or 3 halogens, 10. —C(O)—N(H)—C 3 -C 6 cycloalkyl, or 11. —C(O)—C 1 -C 6 alkyl; R 3 is 1. Hydrogen, 2. —C 1 -C 6 alkyl optionally substituted with hydroxy, —S(O) n C 1 -C 6 alkyl, heterocycle, or 1, 2, 3, 4, 5 or 6 halogens, 3. aryl or C 6 -C 12cyclo alkyl optionally substituted with phenyl, —C 1 -C 6 alkyl, —S(O) n C 1 -C 6 alkyl, —C(O)—O—C 1 -C 6 alkyl, —COOH, hydroxy-C 1 -C 6 alkyl- or 1, 2 or 3 halogens, 4. heterocycle or optionally substituted with 1, 2 or 3 substituents independently selected from phenyl, halogen, C 1 -C 6 alkyl, hydroxyC 1 -C 6 alkyl, —COOH, —C(O)—O—C 1 -C 6 alkyl, 5. amino, 6. —C(O)—O—C 1 -C 6 alkyl, 7. —C 1 -C 6 alkyl-O-phenyl optionally substituted with 1, 2 or 3 halogens, 8. —C 1 -C 6 alkyl-phenyl optionally substituted with 1 or 2 substituents selected from hydroxy and halo, 9. —COOH, 10. Halogen, 11. —SO n —(C 1 -C 6 alkyl), 12. —N(H)—S(O) n —C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 halogen, 13. —N(H)—C(O)—C 1 -C 6 alkyl, 14. —N(H)-heterocycle optionally substituted with 1, 2 or 3 halogens, 15. —N(H)-aryl optionally substituted with 1, 2 or 3 halogens, 16. —N(H)—C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 halogens, 17. —C(O)—N(H)—C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 halogens, 18. —C(O)—NH—C 3 -C 6 cycloalkyl, 19. —O—C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 halogens or phenyl optionally substituted with 1, 2, or 3 halogen; R 4 is 1. H, 2. Halogen, 3. —CN 4. —C 1 -C 6 alkyl, 5. —O—C 1 -C 6 alkyl optionally substituted with 1, 2 or 3 halogens, 6. —C 1 -C 6 alkyl-phenyl with phenyl optionally substituted with halogen, or 7. Oxo.