Patent ID: 7291639

Claim:
A method for treatment of thrombosis in a mammal, the method comprising administering to a mammal in need thereof a pharmaceutically effective amount of a compound of formula I: wherein A is C; B is O; E is —X-D; D is; X is CO, CH(OH), CH 2 , or —CH—S-2-benzothiazole; Y is hydrogen, alkyl of 1-6 carbon atoms, or halogen; Z is O, S, or N; R is hydrogen, nitro, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, or trifluoromethyl; R 1 is alkyl of 1-12 carbon atoms, aryl of 6-10 carbon atoms, aralkyl of 7-15 carbon atoms, halogen, Het-alkyl wherein the alkyl moiety contains 1-6 carbon atoms, or aryl mono-, di- or tri-substituted with a substituent selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, trifluoromethyl, and alkoxy of 1-6 carbon atoms; Het is G is O, S, or N; R 2 is hydrogen, halogen, alkyl of 1-6 carbon atoms, or —OR 5 R 3 and R 4 are each, independently, hydrogen, halogen, alkyl of 1-8 carbon atoms, aryl of 6-12 carbon atoms, nitro, amino, alkylsulfoamide, arylsulfoamide, cycloalkyl of 3-8 carbon atoms, heterocycle of 5 to 7 ring atoms containing from 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur, or aryl of 6-10 carbon atoms mono-, di- or tri-substituted with a substituent selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, trifluoromethyl, and alkoxy of 1-6 carbon atoms; R 5 is hydrogen, alkyl of 1-6 carbon atoms, CH(R 7 )R 8 , —C(CH 2 ) n CO 2 R 9 , —C(CH 3 ) 2 CO 2 R 9 , CH(R 7 )(CH 2 ) n CO 2 R 9 , or —CH(R 7 )C 6 H 4 CO 2 R 9 ; R 6 is alkylene of 1-3 carbon atoms; R 7 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, aralkyl of 6-12 carbon atoms, cycloalkyl of 3-8 carbon atoms, phthalic acid, or Q-alkyl wherein the alkyl moiety contains 1-6 carbon atoms; Q is R 8 is —CO 2 R 11 , —CONHR 11 , tetrazole, or —PO 3 R 11 ; R 9 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, or aralkyl of 7-15 carbon atoms; W is O, N, or S; R 11 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-12 carbon atoms, or aralkyl of 7-15 carbon atoms; n=1-6; or a pharmaceutically acceptable salt or ester form thereof.