Patent ID: 7265093

Claim:
A method of treating Celiac Sprue, the method comprising: orally administering to a patient an effective dose of 0.01 mg to 500 mg/kg body weight per day of a tissue transglutaminase (tTGase) inhibitor wherein said tTGase inhibitor has the formula: wherein R 1 is selected from arylether, aryl, alkylether or alkyl group; R 2 is selected from the group consisting of (S)-Bn, (S)-CO 2 Me, (S)-Me, (R)-Bn, (S)-CH 2 CONHBn, (S)-(1H-indol-yl)-methyl, and (S)-(4-hydroxy-phenyl)-methyl; R 3 is selected from F, I, Cl, and Br; n is from 0 to 3; and X is selected from the group consisting of O and NH, wherein said tTGase inhibitor attenuates gluten toxicity in said patient.