Patent ID: 7388111

Claim:
A compound of formula I wherein: R 1 is halogen, C 1-6 alkyl, C 1-6 alkoxy, nitro or amino; R 2 is hydrogen or fluorine R 3 is phenyl substituted with one to three substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, halogen, cyano and nitro; R 4 is hydrogen, C 1-6 alkyl or halogen; Ar is a substituted phenyl ring according to formula IIa with the proviso that R 7a and R 7c are not both hydrogen or if R 7c is hydrogen then R 7a is halogen, C 1-6 haloalkyl, C 1-6 alkoxy, cyano or C 1-6 alkyl wherein: R 7a is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-3 haloalkyl, C 3-7 cycloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, halogen and cyano; R 7c is selected from the group consisting of hydrogen, —S(O) 2 NR 8 R 9 , —X 2 CH 2 (CH 2 ) p S(O) 2 NR 8 R 9 ; —X 4 (CH 2 ) v COOR 10 , —X 4 (CH 2 ) v CN, —OR 13 , —CO 2 R 11 , —CN, —CONR 8a R 9a and X 4 (CH 2 ) v CONR 8a R 9a ; R 7b in each incidence is independently selected from the group consisting of C 1-6 alkyl; C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 sulfonyl, amino C 1-6 alkylsulfonyl, SO 2 NR 11a R 11b , C 1-6 haloalkoxy, C 1-6 haloalkylthio, halogen, hydroxy, amino, C 1-6 alkylamino, C 1-6 dialkylamino, aminoacyl, acyl, CONR 8 R 9 , nitro, cyano and C 1-6 heteroalkoxy; R 8 and R 9 (i) taken independently, one of R 8 and R 9 is hydrogen or C 1-6 alkyl and the other of R 8 and R 9 is selected from the group consisting of hydrogen, C 1-6 alkyl, —C(═O)R 12 , —(CH 2 ) 2 N[(CH 2 ) 2 ] 2 X 3 or —(CH 2 ) 2 NR 11a R 11b ; or, (ii) R 8 and R 9 taken together are (CH 2 ) 2 —X 3 —(CH 2 ) 2 or —(CH 2 ) o — wherein the —(CH 2 ) o — moiety is optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NR 11a R 11b ; R 8a and R 9a (i) taken independently, one of R 8 and R 9 is hydrogen or C 1-6 alkyl and the other of R 8 and R 9 is selected from the group consisting of hydrogen, C 1-6 hydroxyalkyl, —(CH 2 ) v N[(CH 2 ) 2 ] 2 X 3 and —(CH 2 ) v NR 11a R 11b or, (ii) R 8a and R 9a taken together with the nitrogen to which they are attached are pyrrolidine, piperidine said pyrrolidine or said piperidine optionally substituted with a hydroxyl or (iii) R 8a and R 9a taken together are (CH 2 ) 2 —X 3 —(CH 2 ) 2 ; R 10 is C 1-6 alkyl; R 11 is hydrogen or C 1-6 alkyl; R 11a and R 11b are independently R 11 ; R 12 is C 1-10 alkyl, —(CH 2 ) s NHR 11a R 11b , —(CH 2 ) s OR 11 , —CH 2 CH(OH)CH 3 , —CH 2 N[(CH 2 ) 2 ] 2 O, —(CH 2 ) 2 CO 2 R 11 , optionally substituted phenyl or pyridinyl; R 13 is hydrogen or C 1-6 alkyl; X 2 is —O— or a bond; X 3 is —O—, —S(O) n — or NR 11 ; X 4 is O— or —S(O) n —; m and n are independently integers from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; s is an integer from 1 to 2; v is an integer from 1 to 6; and, hydrates, solvates, and pharmaceutically acceptable salts thereof.