Patent ID: 8119789

Claim:
A DNAzyme which binds to GATA-3 mRNA and functionally inactivates it, which comprises: a catalytic domain with the nucleotide sequence GGCTAGCTACAACGA SEQ ID NO: 154 or a modified sequence with comparable biological effect, which cleaves the GATA-3 mRNA at every purine:pyrimidine binding site to which it is bonded, a right substrate binding domain adjoining the 3′ end of the catalytic domain having polynucleotide sequence GTCTTGGAG and a left substrate binding domain adjoining the 5′ end of the catalytic domain having polynucleotide sequence GTGGATGGA, both substrate binding domains being respectively complementary to two regions of the GATA 3 mRNA so that they hybridize with the mRNA, and which is active in vivo.