Patent ID: 8580918

Claim:
A compound of formula I: wherein: R 1 is chosen from the group consisting of H, alkyl, aralkyl and aryl; a is chosen from the group consisting of 0, 1, 2, 3, 4, 5, 6, and 7; R 2 is a heteroaryl; b is 1 or 2; R 3 and R 4 are each independently selected from the group consisting of H and alkyl; c and d are each independently chosen from the group consisting of 0 and 1; R 5 is chosen from the group consisting of, H and alkyl; e is chosen from the group consisting of 1, 2, 3, and 4; R 6 is chosen from the group consisting of H, alkyl, cycloalkyl, aryl, biaryl, heteroaryl, and —C(O)—NH 2 , wherein the amino acid of which R 6 is a part is in the D configuration; f is chosen from the group consisting of 0, 1, 2, and 3, with the proviso that if R 6 is other than H, f is not 0; R 7 is chosen from the group consisting of alkyl, cycloalkyl, aryl, biaryl, diaryl, heteroaryl and —C(O)—NH 2 ; g is chosen from the group consisting of 1, 2, and 3; R 8 is chosen from the group consisting of H, alkyl, —CH(OH)—CH 3 ; h is chosen from the group consisting of 0, 1, 2, and 3; X 1 is Gln or Arg; X 2 , X 3 , and X 4 are each independently present or absent and if present, independently selected from the group consisting of Val, Leu, Ile, Ser, Thr, Asp, and Glu; Z is NR 9 R 10 or OH, wherein: R 9 and R 10 are each independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, heteroaralkyl, aralkyl, and (CH 2 ) x —[(CH 2 ) 2 —O] y —(CH 2 ) x —[NH—C(O)—CH 2 —O—CH 2 ] z —C(O)—NHR 11 , wherein: R 11 is H or —[(CH 2 ) 2 —O] y —(CH 2 ) x —C(O)—NH 2 each x is independently selected from the group consisting of 0, 1, 2, and 3, each y is independently selected from the group consisting of 3, 4, 5, and 6, z is 0 or 1, and R 9 and R 10 are optionally joined to form a 4- to 7-membered ring which may be a heterocycle or a heteroaryl; and pharmaceutically acceptable salts thereof.