Patent ID: 7989650

Claim:
A method of treatment of an extracorporeal organ that is a donated transplantation organ and is outside the donor's body or an isolated organ of a patient that is inside or attached to a patient's body but is isolated from the patient's blood supply, said method comprising contacting the extracorporeal organ of a donor or the isolated organ of a patient with a composition including a carbon monoxide-releasing metal carbonyl compound or pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier to limit post-ischemic damage to said extracorporeal organ of a donor or said isolated organ of a patient; wherein the carbon monoxide-releasing metal carbonyl compound is of the formula M(CO) x A y B z , where x is at least one, y is at least one, M is a transition metal; each A is a ligand other than CO and is monodentate or polydentate with respect to M and is selected from: alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, [O(CH 2 COO) 2 ] 2− , and [NH(CH 2 COO) 2 ] 2− , and B is optional and is a ligand other than CO.