Patent ID: 7713987

Claim:
A compound of formula (I) or a salt or N-oxide thereof; wherein R 3 is aryl or heteroaryl, each optionally substituted; X 3 and X 4 are independently CH or N; X 5 is selected from the group consisting of CR 12 R 13 , O, S, SO, SO 2 , and NR 14 wherein R 12 and R 13 are independently selected from H, OH, and lower alkyl, or together form an oxo group; R 4 is selected from the group consisting of OH, acyl, formyl, sulfonyl, alkoxy, carboxylate, haloalkyl, halogen, cyano, nitro, trifluoromethoxy, difluoromethoxy, and fluoromethoxy; R′, R 5 , R 6 and R 14 are independently selected from the group consisting of H, lower alkyl, R p , cycloalkyl and aryl, and wherein at least one of R′, R 5 , R 6 and R 14 is R p linked via —C(O)O—, —C(S)O—, -C(O)S—, —C(S)S—, —C(O)NH— or —C(S)NH—; R p is —(CR 1 R 2 ) n —R; R is selected from the group consisting of acetate, amino, dialkylamino, —C(O)OH, alkyl, allyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, phenylalkaryl and heteroarylalkyl, each of which is optionally substituted; R 1 and R 2 are each independently selected from the group consisting of H, OH, —OR 11 , NR 15 R 15 , halo, lower alkyl, C(O)O-alkyl, —C(O)OH, —OP(═O)(OR 11 ) 2 , —OC(═O)OR 11 , —OC(═O)R 11 , cycloalkyl, aryl, and heteroaryl or together form an oxo, wherein each R 15 is independently selected from the group consisting of H, lower alkyl, prenyl, allyl, —C(O))-alkyl, cycloalkyl, aryl, heteroaryl, alkaryl and alkheteroaryl, or two of R 15 combine to form an optionally substituted cycloheteroalkyl; each R 11 is independently H or lower alkyl; n is an integer from 0 to 10; R 7 and R 8 are independently selected from the group consisting of H, halogen, lower alkyl, cycloalkyl, aryl, and heteroaryl; and R 9 and R 10 are independently selected from the group consisting of H, halogen, —OH, -alkoxy, lower alkyl, cycloalkyl, aryl, and heteroaryl wherein R 7 and R 8 , or R 9 and R 10 together form an oxo group, and wherein R 9 or R 10 are not —OH or alkoxy when X 5 is NR 14 .