Patent ID: 7868018

Claim:
A compound of Formula I: in which: R 1 is selected from hydrogen and —NR 7 R 8 ; wherein R 7 is selected from hydrogen and C 1-6 alkyl; R 8 is selected from hydrogen, C 1-6 alkyl, —X 1 NR 9 R 9 , —X 1 OR 10 , C 6 -10 aryl-C 0-4 alkyl, C 1-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein X 1 is C 1-4 alkylene; each R 9 is independently selected from hydrogen and C 1-6 alkyl; R 10 is C 6-10 aryl-C 1-4 alkyl; wherein said aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 8 is optionally substituted with 1 to 3 radicals independently selected from hydroxy, C 1-6 alkyl, hydroxy-subsituted -C 1-6 alkyl, —S(O) 0-2 R 9 , —NR 9 S(O) 0-2 NR 9 R 9 , —C(O)NR 9 R 9 , —OX 2 NR 9 R 9 and C 3-8 heterocycloalkyl optionally substituted with —NR 9 R 9 ; wherein X 2 is selected from a bond and C 1-4 alkylene; and each R 9 is independently selected from hydrogen and C 1-6 alkyl; R 2 is selected from NR 9 C(O)R 9 , NR 9 C(O)R 11 , NR 9 C(O)X 2 NR 9 R 9 and —NR 9 C(O)X 2 NR 9 R 11 ; wherein X 2 and R 9 are as described above and R 11 is selected from C 6-10 aryl-C 1-4 alkyl and C 3-12 cycloalkyl; wherein any aryl or cycloalkyl of R 11 is optionally substituted with C 1-10 alkyl, C 2-10 alkenyl, C 1-10 alkoxy and halo-substituted-C 1-10 alkyl; R 3 and R 4 are independently selected from hydrogen, halo and C 1-6 alkyl; or R 2 and R 4 , together with the atoms to which R 2 and R 4 are attached, form a 5 member heterocycloalkyl ring containing a heteroatom or group selected from —NR 9 —, —O—and —S—; wherein R 9 is selected from hydrogen and C 1-6 alkyl; R 5 is halo-substituted-C 1-6 alkyl; R 6 is selected from hydrogen and C 1-10 heteroaryl; wherein any heteroaryl of R 6 is optionally substituted by 1 to 3 C 1-6 alkyl radicals; or a pharmaceutically acceptable salt thereof.