Patent ID: 7405305

Claim:
A compound of Formula I where: Ar is benzofur-7-yl optionally substituted in the phenyl ring with R 8 and R 9 , or 2,3-dihydrobenzofur-7-yl optionally substituted in the phenyl ring with R 8 and R 9 and in the dihydrofuryl ring with C 1 -C 4 alkyl; G is independently at each occurrence hydroxy, NR 11 R 12 , or piperidin-4-yl; R 2 is hydrogen, C 1 -C 4 alkyl, —(CH 2 ) m -G, tetrahydropyran-4-yl, 4-(NR 4 R 5 )cyclo-hex-1-yl, 4-hydroxycyclohex-1-yl, 2-azabicyclo[3.2.1]oct-5-yl, the moiety the moiety cyclohexan-1-on-4-yl, pyridin-4-yl; and R 3 is hydrogen, halo, C 1 -C 4 alkyl, or cyclopropyl; R 4 hydrogen and R 5 is hydrogen or C 1 -C 4 alkyl, or R 4 and R 5 taken together with nitrogen to which they are attached form a pyrrolidine ring; R 6 is hydrogen, benzyl, —CO 2 (C1-C 4 alkyl), —C(O)—(C 1 -C 4 alkyl) n -NR 14 R 15 , —C(O)tetrahydropyran-4-yl, —C(O)morpholin-4-yl, —CH 2 -tetrahydropyran-4-yl, an amino acid residue, —C(O)pyridin-2-yl, —C(O)pyridin-3-yl, —C(O)pyridin-4-yl, —C(O)pyrimidin-5-yl, C 1 -C 4 alkyl, —C(O)pyrazin-2-yl, or —CO 2 —(C 1 -C 4 alkyl)-(C 1 -C 4 alkoxy); R 8 is —NHCO 2 (C 1 -C 4 alkyl), —NHSO 2 (C 1 -C 4 alkyl), halo, amino, —O—(CH 2 ) m -G, —NHC(O)(C 1 -C 4 alkyl), C 1 -C 4 alkoxy, hydroxy, —O—R 10 , C 1 -C 4 alkyl, C 1 -C 4 alkylthio, or —(CH 2 ) m -G; R 9 is halo; R 10 is piperidin-3-yl, piperidin-4-yl, or pyrrolidin-3-yl; R 11 and R 12 are independently selected from the group consisting of hydrogen, C 1 -C 4 alkyl, cyclopropylmethyl, benzyl, or, taken together with the nitrogen to which they are attached form a piperidine, 4-hydroxypiperidine, 4-(C 1 -C 4 alkyl)piperidine, N—(R 13 )-piperazine, or morpholine ring; R 13 is hydrogen, C(O)—(C 1 -C 4 alkyl), or C 1 -C 4 alkyl; R 14 and R 15 are independently hydrogen or C 1 -C 4 alkyl; R 16 is independently at each occurrence hydrogen, geminal dimethyl, geminal diethyl, a spiro-fused C 3 -C 6 cycloalkyl, or C 1 -C 4 alkyl optionally substituted with hydroxy; and R 17 represents hydrogen, C 1 -C 4 alkyl, or geminal dimethyl, provided that the total number of carbon atoms between R 16 and R 17 does not exceed five; m is independently at each occurrence 2, 3, 4, or 5; n is independently at each occurrence 0 or 1; or a pharmaceutically acceptable salt thereof, subject to the following provisos: i) when G is hydroxy, no more than two of R 1a , R 2 , or R 8 may be —(CH 2 ) m -G, or —O—(CH 2 ) m -G; and ii) when G is NR 11 R 12 , no more than one of R 1a , R 2 , or R 8 may be —(CH 2 ) m -G, or —O—(CH 2 ) m -G.