Patent ID: 7119094

Claim:
A compound having the formula or a pharmaceutically acceptable salt thereof, where the substituents are selected to form compounds selected from the group consisting of: B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-cyanophenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-aminophenyl, and Y 0 is 4-amidino-3-fluorobenzyl; B is isopropyl, A is a bond, R 1 is hydrogen, R 2 is 3-aminophenyl, and Y 0 is 4-amidino-3-fluorobenzyl; B is aminomethyl, A is CH 2 , R 1 is chloro, R 2 is phenyl, and Y 0 is 4-amidinobenzyl; B is aminomethyl, A is CH 2 CH 2 , R 1 is chloro, R 2 is phenyl, and Y 0 is 4-amidinobenzyl; B is aminomethyl, A is CH 2 CH 2 CH 2 , R 1 is chloro, R 2 is phenyl, and Y 0 is 4-amidinobenzyl; B is cyanomethyl, A is CH 2 , R 1 is chloro, R 2 is phenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-carbomethoxyphenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 5-amino-2-fluorophenyl, and Y 0 is 4-amidino-2-fluorobenzyl; B is t-butyl, A is a bond, R 1 is chloro, R 2 is 3-aminophenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-(N-methylamino)phenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 2-methyl-3-aminophenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is hydrogen, R 2 is 3-(N-methylamino)phenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-amino-6-(S—CH 2 —CO 2 H)phenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-amino-6-(S—CH 3 )phenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is hydrogen, R 2 is 3,5-diaminophenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is hydrogen, R 2 is 3-amino-5-(NH—C(O)—CF 3 )phenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-amino-5-carboxyphenyl, and Y 0 is 4-amidinobenzyl; B is isopropyl, A is a bond, R 1 is bromo, R 2 is 3-aminophenyl, and Y 0 is 4-amidinobenzyl; and B is isopropyl, A is a bond, R 1 is chloro, R 2 is 3-amino-methoxycarbonylphenyl, and Y 0 is 4-amidinobenzyl.