Patent ID: 8029986

Claim:
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from: (a) nucleotides 1 to 9104 of SEQ ID NO: 1 or 2; (b) nucleotides 1 to 7584 of SEQ ID NO: 1 or 2; (c) nucleotides 1 to 7581 of SEQ ID NO: 1 or 2; (d) a nucleotide sequence coding for the protein sequence of SEQ ID NO:8 or 9 or for the protein sequence of SEQ ID NO:8 or 9 containing at least one mutation selected from a mutation encoded by a nucleic acid sequence containing a mutation at position 2378, 2789, 3287, 3342, 3364, 3683, 4321, 5096, and/or 6059 of SEQ ID NO:1 or SEQ ID NO:2; (e) a nucleotide sequence complementary to either of the nucleotide sequences in (a), (b), (c) or (d); and/or (f) a nucleotide sequence which hybridizes under high stringency conditions to any of the nucleotide sequences in (a), (b), (c), (d) or (e) and wherein a complementary strand of the nucleotide sequence codes for the protein sequence of SEQ ID NO:8 or 9 or for the protein sequence of SEQ ID NO:8 or 9 containing at least one mutation selected from a mutation encoded by a nucleic acid sequence containing a mutation at position 2378, 2789, 3287, 3342, 3364, 3683, 4321, 5096, and/or 6059 of SEQ ID NO:1 or SEQ ID NO:2, wherein said high stringency conditions comprise hybridization at 68° C. in a solution comprising 50% formamide, 5×SSC (Sodium and Sodium Citrate buffer) or 5×SSPE (Sodium, Sodium Phosphate, and EDTA buffer at pH 7.7), 5×Denhardt's solution, 1% Sodium Dodecyl Sulfate (SDS), and 100 μg/ml denatured salmon sperm DNA, followed by washing at 68° C. in a buffer comprising 0.2×SSC and 0.1% SDS.