Patent ID: 8415474

Claim:
A one-pot process for the preparation of a compound having Formula (IV) from a mixture of compounds having Formulas (II) and (II′), the process comprising: (a) contacting the compounds having Formulas (II) and (II′) with an asymmetric catalyst and a hydrogen donor comprising a formate ion to form a mixture of compounds having Formulas (III) and (III′); and (b) contacting the compounds having Formulas (III) and (III′) with an alkali metal and an electron source to form the compound having Formula (IV) according to the following reaction scheme: wherein: R 1 , R 5 , and R 7 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, and —OR 111 ; R 2 and R 6 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, and —OR 211 ; R 3 is chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, and —OR 211 ; R 4 is chosen from —C(O)R 212 , —C(O)C(R 212 ) 3 , —C(O)NHR 212 , and —SO 2 R 212 ; R 12 and R 13 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, and —OR 111 ; R 111 is chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 211 is chosen from hydrogen, hydrocarbyl, —C(O)R 212 , —C(O)C(R 212 ) 3 , —C(O)NHR 212 , and —SO 2 R 212 ; and R 212 is chosen from hydrocarbyl and substituted hydrocarbyl, and further wherein the compounds haying Formulas (III) and (III′) are not crystallized prior to step (b).