Patent ID: 8450527

Claim:
A method for treating an ophthalmic disease or disorder resulting at least in part from lipofuscin pigment accumulation in a subject, comprising administering to the subject a compound of Formula (A) or tautomer, stereoisomer, geometric isomer or a pharmaceutically acceptable salt, or N-oxide thereof: wherein, Z is —C(R 9 )(R 10 )—C(R 1 )(R 2 )—, G is —C(R 41 ) 2 —C(R 41 ) 2 —R 40 , R 40 is —C(R 16 )(R 17 )(R 18 ; each R 41 is hydrogen; R 1 and R 2 are each independently selected from hydrogen, halogen, C 1 -C 5 unsubstituted alkyl, or hydroxy; or R 1 and R 2 together form an oxo; R 3 and R 4 are hydrogen; R 9 and R 10 are each independently selected from hydrogen, halogen, C 1 -C 5 unsubstituted alkyl, or hydroxyl or R 9 and R 10 form an oxo; R 11 and R 12 are hydrogen; R 16 and R 17 are each independently selected from hydrogen, phenyl, benzyl, or C 1 -C 5 alkyl optionally substituted with —OR a or —C(O)NR a 2 wherein R a is hydrogen or methyl; or R 16 and R 17 , together with the carbon to which they are attached form a carbocyclyl or heterocycle; R 18 is selected from hydrogen, C 1 -C 5 unsubstituted alkyl, methoxy, or hydroxy; R 33 is C 1 -C 5 alkyl; and n is 0, or 1.