Patent ID: 8809267

Claim:
A method of treating hepatitis C in a human patient, said method comprising administering to the patient a pharmaceutical composition comprising an excipient and a compound of formula (V) or a pharmaceutically acceptable salt thereof: wherein: Z 1 is: Z 2a is H, (C1-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, haloalkyl, (C1-10)alkyl-S(═O) 2 —(C1-10)alkyl, or cycloalkyl, wherein any carbon atom of Z 2a may optionally be replaced with a heteroatom selected from the group consisting of O, S, S(═O), S(═O) 2 , and NH; and wherein any cycloalkyl is optionally substituted with one or more (C1-4)alkyl, (C2-4)alkenyl, (C2-4)alkynyl, haloalkyl, F, Cl, Br, or I; R f is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, or cycloalkyl, wherein each alkyl, alkenyl, alkynyl, aryl, heteroaryl, or cycloalkyl is optionally substituted with one or more R g ; Q 1 is H, (C1-10)alkyl, (C2-10)alkenyl, or (C2-10)alkynyl wherein said (C1-10)alkyl, (C2-10)alkenyl, or (C2-10)alkynyl is optionally substituted with one or more R c ; or Q 1 and Z 2a taken together with the atoms to which they are attached form a heterocycle, wherein said heterocycle may optionally be substituted with one or more oxo (═O) or halo; X is a bond, O, S, or NH; Y 4 is (C2-10)alkyl, (C3-7)cycloalkyl, heterocycle, polycarbocycle, or polyheterocycle, wherein said (C2-10)alkyl, (C3-7)cycloalkyl, heterocycle, polycarbocycle, or polyheterocycle is optionally substituted with one or more (C1-10)alkyl, halo, carboxy, hydroxy, (C1-10)alkanoyl, (C1-10)alkoxy, (C1-10)alkanoyloxy, (C1-10)alkoxycarbonyl, trifluoromethyl, NR n R p , SR r , S(O)R r , or S(O) 2 R r ; each R c is independently cyano, F, Cl, Br, S(O) 2 R r , (C1-10)alkoxy, or cycloalkyl; each R d is independently H, (C1-10)alkyl, or aryl, wherein each (C1-10)alkyl, or aryl is optionally substituted with one or more halo; each R g is independently H, alkyl, alkenyl, alkynyl, halo, hydroxy, cyano, arylthio, cycloalkyl, aryl, heteroaryl, alkoxy, NR h R i , —C(═O)NR h R i , or —C(═O)OR d , wherein each aryl and heteroaryl is optionally substituted with one or more alkyl, halo, hydroxy, cyano, nitro, amino, alkoxy, alkoxycarbonyl, alkanoyloxy, haloalkyl, or haloalkoxy; and wherein each alkyl is optionally substituted with one or more halo, alkoxy, or cyano; each R h and R i is independently H, alkyl, or haloalkyl; each R n and R p is independently H, (C1-10)alkyl, (C2-10)alkenyl, (C2-10)alkynyl, (C1-10)alkanoyl, (C1-10)alkoxy, (C1-10)alkanoyloxy, or (C1-10)alkoxycarbonyl, wherein each (C1-10)alkyl, (C2-10)alkenyl, (C2-10)alkynyl, (C1-10)alkanoyl, (C1-10)alkoxy, (C1-10)alkanoyloxy, or (C1-10)alkoxycarbonyl is optionally substituted with one or more halo, hydroxy, carboxy, cyano, or (C1-10)alkoxy; or R n and R p together with the nitrogen to which they are attached form a pyrrolidine, piperidine, piperazine, morpholino, or thiomorpholino ring; and each R r is independently (C1-10)alkyl.