Patent ID: 8153585

Claim:
A method of treating a subject having a disease or disorder associated with VEGF-induced neovascularization or angiogenesis, which comprises administering to the subject a pharmaceutical composition comprising an isolated polypeptide: (i) comprising a portion of SEQ ID NO:1 having VEGF antagonist activity; (ii) comprising SEQ ID NO:2 or a portion thereof having VEGF antagonist activity; or (iii) comprising a peptide having the structure of the following formula (I): (X 1 -(CSCKNTDSRCKARQLELNERT(SEQ ID NO:3))X 2 I wherein X 1 is H, or any portion of amino acids 2-21 of SEQ ID NO:1, and X 2 is H or C, CR, RC, or CRC; and a pharmaceutically acceptable carrier.