Patent ID: 8044227

Claim:
A method of making a compound of Formula 9, or a pharmaceutically acceptable complex, salt, solvate or hydrate thereof, the method comprising: (a) reducing a cyano moiety of a compound of Formula 16, or a salt thereof, to yield the compound of Formula 9 or a salt thereof; (b) optionally converting the compound of Formula 9 or a salt thereof into a pharmaceutically acceptable complex, salt, solvate or hydrate; (c) wherein the compound of Formula 16 is prepared by decarboxylating a compound of Formula 11, or a salt thereof; (d) wherein the compound of Formula 11 is prepared by contacting a compound of Formula 12, with an enzyme to yield the compound of Formula 11 and said enzyme is adapted to enantioselectively hydrolyze the compound of Formula 12 to the compound of Formula 11, or a salt thereof; R 3 in Formula 11 and 12 are each independently represented by C 1-12 alkyl, C 3-12 cycloalkyl, or aryl-C 1-6 alky, R 4 in Formula 12 is represented by C 1-12 alkyl, C 3-12 cycloalkyl, or aryl-C 1-6 alky, and; R 5 in Formula 16 is represented by hydrogen, C 1-12 alkyl, C 3-12 cycloalkyl, or aryl-C 1-6 alkyl.