Patent ID: 8771932

Claim:
A method of stimulating proliferation, differentiation, or growth of promegakaryocytes or megakaryocytes, comprising contacting promegakaryocytes or megakaryocytes with an effective amount of an immunoglobulin molecule or fragment thereof comprising one or more thrombopoietin (TPO) mimetic peptides, wherein: a) said one or more TPO mimetic peptides replace at least a portion of one or more complementarity determining regions (CDRs) or b) said one or more TPO mimetic peptides are fused to one or more CDRs, wherein said immunoglobulin molecule or fragment thereof comprising the one or more TPO mimetic peptides binds to a TPO receptor, and wherein said immunoglobulin or fragment thereof comprising one or more TPO mimetic peptides comprises one or more immunoglobulin framework regions.