Patent ID: 6919331

Claim:
A compound having the Formula I, and pharmaceutically acceptable salts thereof, wherein: R 1 is —(CR a R b ) n —X; R a and R b are each independently selected from the group consisting of H and C 1-6 alkyl; said C 1-6 alkyl being optionally substituted with one to six same or different halogen; X is H or C 1-6 alkyl; said C 1-6 alkyl being optionally substituted with halogen, OR c or S(O) m R d ; R c is H or COR d ; R d is C 1-6 alkyl; n is 1-6; m is 0-2; R 2 is H; R 3 is hydrogen, CONR h R i , CO 2 R d or C 1-6 alkyl; said C 1-6 alkyl can be optionally substituted with OR e or NR f R g ; R e is H or C 1-6 alkyl; R f and R g are each independently H, C 1-6 alkyl, SO 2 R d , CO 2 R d or COR d ; R h and R i are each independently H or C 1-6 alkyl; R 4 is selected from the group consisting of hydrogen, amino, CONR h R i , heteroaryl selected from the group consisting of oxadiazole, oxazole, and oxadiazolinone, C 2-6 alkenyl, CO 2 R d , N═CPh 2 , C(═NOH)NH 2 , C(═NH)NH 2 and C 1-6 alkyl; said C 1-6 alkyl optionally substituted with a member selected from the group consisting of halogen, CN, NR l R m , OSO 2 R d and OR e ; R l and R m are each independently selected from the group consisting of H, C 1-6 alkyl, C 3-6 cycloalkyl, CO 2 R d , COR d and SO 2 R d ; R 5 is selected from the group consisting of (1) hydrogen; (2) CO 2 R j ; (3) C 1-6 alkyl optionally substituted with CN, OR e or NR f R g ; and (4) C 2-6 alkenyl substituted with CN; R l is H or C 1-6 alkyl; provided that R 3 , R 4 , and R 5 are not all hydrogen; Q is a member selected from the group consisting of F 1 is CH or N; R 6 is H, halogen, C 1-6 alkyl or C 2-6 alkenyl; R 7 is H, C 1-6 alkyl, C 2-6 alkenyl, CO 2 R d or C 3-6 cycloalkyl; R 8 is H or C 1-6 alkyl; said C 1-6 alkyl optionally substituted with one to three halogen; R 9 is C 1-6 alkyl or C 3-6 cycloalkyl; said C 1-6 alkyl optionally substituted with one to three halogen; R 10 is C 1-6 alkyl or C 3-6 cycloalkyl; said C 1-6 alkyl optionally substituted with one to three halogen; R 11 is H or C 1-2 alkyl; R 12 is H; and R 13 is H or OR j .