Patent ID: 8333193

Claim:
A method of making a non-powder-form freeze-dried composition comprising: at least partially filing a vessel with a solution; and freeze drying the solution in the vessel to form the non-powder-form freeze-dried composition; wherein the non-powder-form freeze-dried composition has at least the following properties: a disintegration index greater than or equal to 0.015; and the non-powder-form freeze-dried composition becomes fine particles upon receiving air impact at an air speed greater than or equal to 1 meter/second and an air flow rate greater than or equal to 17 milliliters/second; and wherein the fine particles have: a mean particle diameter less than or equal to 1×10 −5 meters; or a fine particle fraction greater than or equal to 10%; or a mean particle diameter less than or equal to 1×10 −5 meters and a fine particle fraction greater than or equal to 10%.