Patent ID: 7057046

Claim:
A compound of formula I wherein W is a bicyclic heteroaryl of the structure X is —CHR 5 —; Y is a bond; Z is selected from A is —CH— or —N—; B is —O— or —S—; R 1 is hydrogen, alkyl, aryl or alkenyl; R 2 is hydrogen, alkyl, aryl, arylalkyl, heteroarylalkyl or alkenyl; R 3 and R 4 are each independently hydrogen, halo, trifluoromethyl, cyano, alkyl or alkoxy; R 5 and R 6 are each independently hydrogen, alkyl, aryl, alkenyl, CN, CN 4 R 9A (tetrazole), CO 2 R 9A , CONR 9A R 9B or CONR 9A OR 9B ; R 7 and R 8 are each independently hydrogen, halo, trifluoromethyl, cyano, hydroxy, a hydrogen bonding group, alkyl, alkoxy, aryl, arylalkyl, heteroarylalkyl, aryloxy or alkenyl; and R 9A and R 9B are independently hydrogen, alkyl, arylalkyl, heteroarylalkyl or aryl, or R 9A and R 9B may optionally be cyclized together to form a ring, wherein said ring may further be substituted with one to three additional hydrogen bonding groups, wherein when R 1 , R 2 , R 5 , R 6 , R 7 and R 8 are alkyl, aryl, alkenyl, arylalkyl, heteroarylalkyl, alkoxy or aryloxy, R 1 , R 2 , R 5 , R 6 , R 7 and R 8 may each independently be substituted with 1 to 3 hydrogen bonding groups; where R 1 , R 2 , R 5 , R 6 , R 7 , R 8 , R 9A or R 9B is a hydrogen bonding group, the hydrogen bonding group is independently selected from the group consisting of OR 9A , OCO 2 R 10 , OCONR 9A R 9B , CN, NO 2 , CN 4 R 9A (tetrazole) COCF 3 , COR 9A CO 2 R 9A , CONR 9A R 9B , CONR 9A OR 9B , C(NR 9A )NR 9B R 9C , CONR 9A SO 2 R 9B , SOR 10 , SO 2 R 10 , SO 3 H, SO 2 NR 9A R 9B , SO 2 NR 9A COR 9B , SO 2 NR 9A CONR 9B R 9C , POR 9A R 9B , PO 2 R 9A R 9B , PO 3 R 9A R 9B , PO 2 R 9A NR 9B R 9C , NR 9A R 9B , NR 9A COR 9B , NR 9A C(NR 9B )R 9C , NR 9A CO 2 R 9B , NR 9A CONR 9B R 9C , NR 9A C(NR 9B )NR 9C R 9D , NR 9A SO 2 R 9B , NR 9A CONR 9B SO 2 R 9C , NR 9A SO 2 NR 9B R 9C , NR 9A POR 9B R 9C , NR 9A PO 2 R 9B R 9C , NR 9A PO 3 R 9B R 9C and NR 9A PO 2 R 9B NR 9C R 9D ; wherein R 9C and R 9D are each independently hydrogen, alkyl, arylalkyl, heteroarylalkyl or aryl; and R 10 is independently alkyl, arylalkyl, heteroarylalkyl, or aryl; wherein R 9A , R 9B , R 9C R 9D or R 10 may further be substituted with one to three additional hydrogen bonding groups as defined above; and wherein two of R 9A , R 9B , R 9C or R 9D within the same hydrogen bonding group as defined above may optionally be cyclized together to form a ring, wherein said ring may further be substituted with one to three additional hydrogen bonding groups as defined above; with the proviso that compounds of formula I exclude compounds of the following structures: 1-t-butoxycarbonylmethyl-3-(carbonyl-2-indolyl)aminodihydrocarbostyril; 2,3-dichloro-5-[N-(2-oxo-1,2,3,4-tetrahydroquinol-3-yl)carbamoyl]-4H-thieno[3,2-b]pyrrole; 2-chloro-5-[N-(2-oxo-1,2,3,4-tetrahydroquinol-3-yl)carbamoyl]-6H-thieno[2,3-b]pyrrole; and 2-chloro-5-[N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinol-3-yl)carbamoyl]-6H-thieno[2,3-b]pyrrole.