Patent ID: 7041687

Claim:
A compound of formula IIa: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from halogen, CN, N(R 4 ) 2 , or T-R; T is selected from a valence bond or a C 1-6 alkylidene chain, wherein up to two methylene units of T are optionally, and independently, replaced by —O—, —N(R)—, —S—, —N(R)C(O)—, —C(O)N(R)—, —C(O)—, or —SO 2 —; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or: two R groups on the same nitrogen, taken together with the nitrogen atom attached thereto, form a 5–7 membered saturated, partially unsaturated, or aromatic ring having 1–3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R 2 is selected from Q-C(R)(Q-Ar)R 3 , wherein: R and R 3 optionally form a 5–7 membered saturated or partially unsaturated ring having 0–4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each Q is independently selected from a valence bond or a C 1-4 alkylidene chain; each Ar is independently an optionally substituted ring selected from a 5–7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0–4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8–10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring having 0–4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R 3 is selected from R′, Ar 1 , Q-OR 5 , Q-OC(O)R 5 , Q-CONHR 5 , Q-OC(O)NHR 5 , Q-SR 5 , Q-N(R 4 ) 2 , N(R)(Q-Ar), N(R)C(O)Q-N(R 4 ) 2 , or N(R)Q-N(R 4 ) 2 ; R′ is an optionally substituted C 1-6 aliphatic group; each R 4 is independently selected from R, COR, CO 2 R, CON(R) 2 , SO 2 R, SO 2 N(R) 2 , or Ar 1 ; each R 5 is independently selected from R or Ar; V 1 , V 2 and V 3 are each independently C(R 6 ); each R 6 is independently selected from R, Ar 1 , halogen, CN, NO 2 , OR, SR, N(R 4 ) 2 , N(R)COR, N(R)CON(R 4 ) 2 , N(R)C(O)OR, CON(R 4 ) 2 , OC(O)N(R 4 ) 2 , CO 2 R, OC(O)R, N(R)SO 2 R, N(R)SO 2 N(R 4 ) 2 , SO 2 R, or SO 2 N(R 4 ) 2 ; and each Ar 1 is independently selected from an optionally substituted 5–7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0–4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; provided that when V 1 , V 2 , and V 3 are each CH and R 1 is hydrogen then R 3 is other than R′, Q-OC(O)R 5 , or OCH 2 phenyl.