Patent ID: 7015221

Claim:
A compound of formula or a N-oxide, a pharmaceutically acceptable salt, or a stereochemically isomeric form thereof, wherein -b 1 =b 2 -C(R 2a )=b 3 -b 4 =represents a bivalent radical of formula —CH═CH—C(R 2a )═CH—CH═ (b-1); —N═CH—C(R 2a )═CH—CH═ (b-2); —CH═N—C(R 2a )═CH—CH═ (b-3); —N═CH—C(R 2a )═N—CH═ (b-4); —N═CH—C(R 2a )═CH—N═ (b-5); —CH═N—C(R 2a )═N—CH═ (b-6); or —N═N—C(R 2a )═CH—CH═ (b-7); q is 0, 1, 2, 3 or 4; R 1 is hydrogen, aryl, formyl, C 1-6 alkylcarbonyl, C 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyl substituted with formyl, C 1-6 alkylcarbonyl, or C 1-6 alkyloxycarbonyl; R 2a is cyano; aminocarbonyl; mono- or di(methyl)aminocarbonyl; C 1-6 alkyl substituted with cyano, aminocarbonyl or mono- or di(methyl)aminocarbonyl; C 2-6 alkenyl substituted with cyano; or C 2-6 alkynyl substituted with cyano; each R 2 independently is hydroxy, halo, C 1-6 alkyl optionally substituted with cyano or —C(═O)R 4 , C 3-7 cycloalkyl, C 2-6 alkenyl optionally substituted with one or more halogen atoms or cyano, C 2-6 alkynyl optionally substituted with one or more halogen atoms or cyano, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C 1-6 alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O) p R 4 , —NH—S(═O) p R 4 , —C(═O)R 4 , —NHC(═O)H, —C(═O)NHNH 2 , —NHC(═O)R 4 , —C(═NH)R 4 or a radical of formula wherein each A independently is N, CH or CR 4 ; B is NH, O, S or NR 4 ; p is 1 or 2; and R 4 is methyl, amino, mono- or dimethylamino or polyhalomethyl; L is C 4-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, or C 3-7 cycloalkyl, whereby each of said aliphatic groups is optionally substituted with one or two substituents independently selected from (i) C 3-7 cycloalkyl, (ii) indolyl or isoindolyl, each optionally substituted with one, two, three or four substituents each independently selected from halo, C 1-6 alkyl, hydroxy, C 1-6 alkyloxy, cyano, aminocarbonyl, nitro, amino, polyhalomethyl, polyhalomethyloxy or C 1-6 alkylcarbonyl, (iii) phenyl, pyridinyl, pyrimidinyl pyrazinyl or pyridazinyl, wherein each of said aromatic rings is optionally substituted with one, two, three, four or five substituents each independently selected from the substituents defined in R 2 ; or L is —X—R 3 wherein R 3 is phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, wherein each of said aromatic rings is optionally substituted with two, three, four or five substituents each independently selected from the substituents defined in R 2 ; and X is —NR 1 —, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O) 2 —; aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, cyano, nitro, polyhaloC 1-6 alkyl or polyhaloC 1-6 alkyloxy.