Patent ID: 7959928

Claim:
A composition comprising: (a) a virus-like particle (VLP) comprising coat proteins, mutants or fragments thereof, of an RNA-bacteriophage with at least one first attachment site, wherein said VLP is recombinantly produced by a host, and said VLP is essentially free of host RNA; (b) at least one antigen with at least one second attachment site; wherein said at least one antigen is linked to said VLP (a) through said at least one first attachment site and said at least one second attachment site; and (c) at least one polyanionic macromolecule packaged inside said VLP, wherein said at least one polyanionic macromolecule is a polyanionic polypeptide selected from the group consisting of: (i) polyglutamic acid; (ii) polyaspartic acid; (iii) poly(GluAsp); and (iv) chemical modifications of (i)-(iii), wherein said modifications are glycosylations, acetylations or phosphorylations; wherein said polyanionic polypeptide does not statistically significantly activate a Toll-like receptor.