Patent ID: 8404690

Claim:
A piperazine-2-carboxamide compound defined by formula (II): or its enantiomers, diastereomers, racemate, or its pharmaceutically acceptable salts, wherein A is aryl or heteroaryl; and X is selected from the group consisting of —CO— and —SO 2 —; Y is selected from the group consisting of —SO 2 —, —CO—, and —CO—NR 3 , wherein R 3 is as defined below; R 1 and R 2 are each independently from each other selected from the group consisting of hydrogen, hydroxy, sulfonyl, amino, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl, heteroaryl, (C 3 -C 8 )-cycloalkyl, and heterocycloalkyl, an acyl moiety, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 2 -C 6 -alkenyl aryl, C 2 -C 6 -alkenyl heteroaryl, C 2 -C 6 -alkynyl aryl, C 2 -C 6 -alkynyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl hetero-cycloalkyl, C 2 -C 6 -alkenyl cycloalkyl, C 2 -C 6 -alkenyl heterocycloalkyl, C 2 -C 6 -alkynyl cycloalkyl, C 2 -C 6 -alkynyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkyl carboxy, C 1 -C 6 -alkyl acyl, aryl acyl, heteroaryl acyl, C 3 -C 8 -(hetero)-cycloalkyl acyl, C 1 -C 6 -alkyl acyloxy, C 1 -C 6 -alkyl alkoxy, C 1 -C 6 -alkyl alkoxycarbonyl, C 1 -C 6 -alkyl aminocarbonyl, C 1 -C 6 -alkyl acylamino, acylamino, C 1 -C 6 -alkyl ureido, C 1 -C 6 -alkyl carbamate, C 1 -C 6 -alkyl amino, C 1 -C 6 -alkyl ammonium, C 1 -C 6 -alkyl sulfonyloxy, C 1 -C 6 -alkyl sulfonyl, C 1 -C 6 -alkyl sulfinyl, C 1 -C 6 -alkyl sulfanyl, C 1 -C 6 -alkyl sulfonylamino and C 1 -C 6 -alkyl aminosulfonyl, provided R 1 and R 2 cannot simultaneously be hydrogen and hydroxyl, wherein R 1 and R 2 optionally form together a 3-8 membered heterocycle optionally comprising a heteroatom selected from the group consisting of 0, N and S; R 3 is selected from the group consisting of H, and straight or branched C 1 -C 6 -alkyl; R 4 and R 5 are each independently from each other selected from the group consisting of straight or branched C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl, heteroaryl, C 3 -C 8 -cycloalkyl or heterocycloalkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, C 2 -C 6 -alkenyl-aryl or -heteroaryl, C 2 -C 6 -alkynyl aryl or -heteroaryl, carboxy, cyano, halogen, hydroxy, C 1 -C 6 -alkoxy, nitro, acylamino, ureido, sulfonylamino, sulfanyl and sulfonyl.