Patent ID: 8110676

Claim:
A compound having general formula (I) TS—O m —(PXX′)—(OPYY′) n —O—(PZZ′)—O p —CT (I) wherein TS is a substituent wherein an included hydroxyl substituent of TS—OH has been removed to produce said TS substituent and wherein TS—OH is selected from the group consisting of 2-amino-9-[(2R,4S,5R)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one, 2′-deoxy-5′-adenylic acid, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione, 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)-oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione, 2′-deoxyguanosine, 2′-deoxyadenosine 7-deaza-2′-deoxyguanosine, 7-deaza-2′-deoxyadenosine, 6-thio-2′-deoxyguanosine, 2′,3′-dideoxyguanosine, 2′,3′-dideoxyinosine, 3′-azido-3′-deoxythymidine, carbovir, adefovir, and tenofovir, CT is a substituent wherein an included hydroxyl substituent of CT-OH has been removed to produce said CT substituent and wherein CT-OH is selected from the group consisting of acyclovir, penciclovir, ganciclovir, 7-methyl-guanosine, gemcitabine, fluorodeoxyuridine, fluorouridine, fludarabine, 2-chloro-2′deoxyadenosine, idoxuridine, cytarabine, triciribine, 5-aza-2′-deoxycytidine, 2′,3′-dideoxy-2′,3′-didehydrouridine, 2′,3′-dideoxyuridine, 5-hydroxy-2′-deoxycytidine, 3-deazauridine, enocitabine, 2′,3′-dideoxycytidine, lamivudine, emtricitabine, (S)-1-(3-hydroxy-1-methoxypropyl)cytosine, (−)-2′-deoxy-3′-oxa-4′-thiocytidine, racivir, reverset, 1-(1,3-dihydroxy-2-propoxy-methyl)cytosine, (2′S)-2′-deoxy-2′-C-methylcytidine, 1-(2-deoxy-2-methylene-β-D-erythro-pentofuranosyl)cytosine, 1-(2-C-cyano-2-deoxy-1-β-D-arabino-pentofuranosyl)cytosine, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine, β-L-1-(5-hydroxymethyl-1,3-dioxolan-2-yl) cytosine, and (E)-2′-deoxy-2′-(fluoromethylene)cytidine, X, Y, and Z are selected from the group consisting of O and S, X′, Y′ and Z′ are selected from the group consisting of O, CT′, O—CT′, R and OR, wherein CT′ is a substituent equal to or different from CT wherein CT′ and CT are both selected from the alternatives encompassed by the above definition of CT, and R is selected from the group consisting of alkyl, lower alkyl, aryl and aryl alkyl, m=0 or 1, n=1 or 2, and p=0 or 1.