Patent ID: 8653265

Claim:
A preparation method of a Rosuvastatin compound of Formula I, the method comprising the steps of: (a) conducting a Witting condensation of a compound of Formula II with a compound of Formula III to form a compound of Formula IV, wherein R 1 is a low alkyl group; (b) deprotecting the silane group of the compound of Formula IV in the presence of hydrofluoric acid to obtain a compound of Formula V; (c) conducting asymmetric reduction on the compound of Formula V in the presence of R 2 2 BOMe and NaBH 4 to form a compound of Formula VI, wherein R 2 is a C 1 -C 8 linear or branched alkyl group; (d) conducting alkaline hydration on the compound of Formula VI in the presence of sodium hydroxide to form a compound of formula VII; (e) conducting acidification of the compound of Formulate VII in the presence of an acid to form a compound of Formula VIII; (f) conducting esterification of the compound of Formula VIII and a halohydrocarbon R 3 X in the presence of alkali to form a compound of Formula IX, wherein R 3 is a low alkyl group or a benzyl and X is a halogen; (g) conducting alkaline hydration on the compound of Formula formula IX in the presence of alkali to form the compound of Formula VII; and (h) converting the compound of Formula VII in the presence of a soluble calcium salt to the compound of Formula I: