Patent ID: 8299051

Claim:
A compound of Formula (I): wherein p is 0, 1, or 2; R 1 and R 2 each independently is H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heteroaryl, wherein any alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heteroaryl can be independently substituted with 0-3 J; wherein R 1 or R 2 , or both, is heteroaryl; J is haloalkyl, (CH 2 ) n —OR′, (CH 2 ) n —OC(O)N(R′) 2 , (CH 2 )n—CN, CF 3 , OCF 3 , O, S, C(O), S(O), methylenedioxy, ethylenedioxy, (CH 2 ) n —N(R′) 2 , (CH 2 ) n —SR′, (CH 2 ) n —S(O)R′, (CH 2 ) n —S(O) 2 R′, (CH 2 ) n —S(O) 2 N(R′) 2 , (CH 2 ) n —SO 3 R′, (CH 2 ) n —C(O)R′, (CH 2 ) n —C(O)C(O)R′, (CH 2 ) n —C(O)CH 2 C(O)R′, (CH 2 ) n —C(S)R′, (CH 2 ) n —C(O)OR′, (CH 2 ) n —OC(O)R′, (CH 2 ) n —C(O)N(R′) 2 , (CH 2 ) n —OC(O)N(R′) 2 , (CH 2 ) n —C(S)N(R′) 2 , (CH 2 ) n —NHC(O)R′, (CH 2 ) n —N(R′)N(R′)C(O)R′, (CH 2 ) n —N(R′)N(R′)C(O)OR′, (CH 2 ) n —N(R′)N(R′)CON(R′) 2 , (CH 2 ) n —N(R′)SO 2 R′, (CH 2 ) n —N(R′)SO 2 N(R′) 2 , (CH 2 ) n —N(R′)C(O)OR′, (CH 2 ) n —N(R′)C(O)R′, (CH 2 ) n —N(R′)C(S)R′, (CH 2 ) n —N(R′)C(O)N(R′) 2 , (CH 2 ) n —N(R′)C(S)N(R′) 2 , (CH 2 ) n —N(R′)C(═NR)N(R′) 2 , (CH 2 ) n —C(═NR)N(R′) 2 , (CH 2 ) n —N(COR′)COR′, (CH 2 ) n —N(OR′)R′, (CH 2 ) n —C(═NH)N(R′) 2 , (CH 2 ) n —C(O)N(OR′)R′, (CH 2 ) n N(R′)C(═NR)N(R′) 2 or (CH 2 ) n —C(═NOR′)R′, wherein n is 0 to 4, and wherein; each R′ is independently at each occurrence hydrogen, (C 1 -C 12 )-alkyl, (C 3 -C 10 )-cycloalkyl or (C 3 -C 10 )-cycloalkenyl, [(C 3 -C 10 )cycloalkyl or (C 3 -C 10 )-cycloalkenyl]-(C 1 -C 12 )-alkyl, (C 6 -C 10 )-aryl, (C 6 -C 10 )-aryl-(C 1 -C 12 )-alkyl, (C 3 -C 10 )-heterocyclyl, (C 3 -C 10 )-heterocyclyl-(C 1 -C 12 )-alkyl, (C 5 -C 10 )-heteroaryl, or (C 5 -C 10 )-heteroaryl-(C 1 -C 12 )-alkyl, wherein any alkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl is substituted with 0-3 substituents selected independently from J; or, two R′ groups together with a nitrogen atom to which both R′ groups are attached or with two adjacent nitrogen atoms to which each R′ group is respectively attached form a mono- or bicyclic ring system; R 3 is OC(O)OR″, OC(O)NHR″, NHC(O)R″, NHC(O)NHR″, or NHC(═NH)NHR″, where R″ is heteroaryl, or (CH 2 ) n NHR′″, wherein n=2, 3, or 4 and R′″=H, C(═NH)NH 2 , C(NH)H, wherein R″ is substituted with 0-3 substituents selected independently from J; and, R 4 is H, a (C 1 -C 6 )alkyl or aryl group, or a pharmaceutically acceptable cation; or a salt, pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.