Patent ID: 8106003

Claim:
An isolated peptide consisting of a first segment that includes a core motif having the amino acid sequence YDRREY (SEQ ID NO:1), or a derivative of the first segment, and optionally, a second segment fused to the first segment such that the isolated peptide is a fusion peptide, wherein the second segment is a cell membrane translocating motif that is peptide-based and is heterologous to a β7 integrin cytoplasmic domain, the first segment has a maximum length of 13 amino acid residues, and the derivative has a maximum length of 13 amino acids and includes an amino acid sequence containing two Y residues which differs from the amino acid sequence YDRREY (SEQ ID NO:1) by one and only one of (a) a conservative amino acid substitution for at least one of the D, R, R, and E residues, and (b) one, two, or three deletions of the D, R, R, and E residues.