Patent ID: 7211574

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt or solvate thereof, wherein p is 0, 1 or 2 and when p is 0, the carbons to which (V) p is shown connected are not linked to each other but are linked to hydrogen; G is hydrogen, halo, alkyl, alkylthio, nitro, nitrile, hydroxy, alkoxy, alkylsulfinyl, alkylsulfonyl, trifluoromethyl or trifluromethoxy; V is —CH 2 —; W is selected from the group consisting of O, S NH and N(alkyl); Z is selected from the group consisting of NH, N(alkyl), S and O; R 1 is hydrogen, alkyl, allyl, cycloalkyl or cycloalkyl(alkyl); R 2 is hydrogen or 1 to 4 substituents which can be the same or different, each R 2 being independently selected from the group consisting of halogen, alkyl, alkylthio, alkylsulfonyl, hydroxy, alkoxy, trifluoromethyl, trifluoromethoxy, aryl, —CH═O, —NO 2 , —NR 11 R 12 , CN, R 10 -substituted aryl, heteroaryl, —C(O)OR 8 , —C(O)NR 3 R 4 , —S(O) 2 NR 3 R 4 , —C(R 7 R 8 )NR 5 R 6 , —C(R 7 )═NOR 4 and —C(R 7 R 8 )OR 6 ; R 3 is aryl, R 10 -substituted aryl, arylalkyl, heteroaryl, alkyl or hydrogen; R 4 is aryl, R 10 -substituted aryl, heteroaryl, alkyl or hydrogen, or R 3 , R 4 and N of —NR 3 R 4 together can be joined together to form a ring selected from the group consisting of azetidine, R 8 -substituted azetidine, pyrrolidine, R 8 -substituted pyrrolidine, piperidine, R 8 -substituted piperidine, piperazine, R 8 -substituted piperazine, morpholine and R 8 -substituted morpholine; R 5 is alkyl, arylalkyl, —C(O)NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 8 , —C(O)R 8 , —C(O)OR 8 or —R 9 O-alkyl; R 6 is hydrogen, alkyl, aryl, R 10 -substituted aryl, heteroaryl or arylalkyl, or R 5 , R 6 and N in —NR 5 R 6 together can be joined together to form a ring selected from the group consisting of azetidine, R 8 -substituted azetidine, pyrrolidine, R 8 -substituted pyrrolidine, piperidine, R 8 -substituted piperidine, piperazine, R 8 -substituted piperazine, morpholine and R 8 -substituted morpholine; R 7 is hydrogen, alkyl, aryl or arylalkyl; R 8 is hydrogen, aryl, alkyl, arylalkyl or heteroaryl; R 9 is hydrogen, alkyl, aryl, R 10 -substituted aryl, heteroaryl or arylalkyl; R 10 is selected from the group consisting of aralkyl, heteroaralkyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, heterocyclyl, Y 1 Y 2 N—, Y 1 Y 2 N-alkyl-, Y 1 Y 2 NC(O)—and Y 1 Y 2 NSO 2 —, wherein Y 1 and Y 2 may be the same or different and are independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl; R 11 is hydrogen, alkyl or arylalkyl; R 12 is —C(O)R 13 , —S(O) 2 R 13 , —C(O)NR 3 R 4 or —C(O)OR 13 ; and R 13 is alkyl, aryl, R 10 -substituted aryl, heteroaryl or arylalkyl.