Patent ID: 7517872

Claim:
A compound of formula I where: R 1 is H, CO 2 R 5 or CONR 6 R 7 ; R 2 is hydroxy, alkoxy, amino, alkylamino, dialkylamino; or R 2 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from alkyl and alkoxy; or R 2 is R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 8 ) 2 NSO 2 , or (R 9 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; R 9 is azetidinyl, pyrrolidinyl, piperidinyl, N-(R 10 )piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; R 10 is hydrogen or alkyl; R 11 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, benzyl, alkylcarbonyl, alkoxycarbonyl, benzyloxycarbonyl, (R 8 ) 2 NCO, alkylSO 2 , or pyridinyl; and X is absent (forming a compound of formula Ia), a bond (forming a compound of formula Ib), or methylene (forming a compound of formula Ic); or a pharmaceutically acceptable salt thereof.