Patent ID: 8268312

Claim:
A method of treating a cancer that expresses alpha-fetoprotein (AFP) comprising: a) obtaining a chimeric, humanized or human anti-AFP antibody or antigen-binding fragment thereof that competes for binding to alpha-fetoprotein with a murine antibody comprising heavy chain complementarity determining region (CDR) sequences CDR1 (SYVIH, SEQ ID NO:4), CDR2 (YIHPYNGGTKYNEKFKG, SEQ ID NO:5) and CDR3 (SGGGDPFAY, SEQ ID NO:6) and light chain CDR sequences CDR1 (KASQDINKYIG, SEQ ID NO: 1), CDR2 (YTSALLP, SEQ ID NO:2) and CDR3 (LQYDDLWT, SEQ ID NO:3); and b) administering the antibody or fragment thereof to a subject with a cancer that expresses AFP.