Patent ID: 6962936

Claim:
A compound of formula II-A or II-B: or a pharmaceutically acceptable salt or derivative thereof, wherein: T and Q are each independently selected from —C(R 7 ) 2 —, —C(O)—, —C(O)C(O)—, —C(O)NR 7 —, —C(O)NR 7 NR 7 —, —CO 2 —, —OC(O)—, —NR 7 CO 2 —, —O—, —NR 7 C(O)NR 7 —, —OC(O)NR 7 —, —NR 7 NR 7 —, —NR 7 C(O)—, —S—, —SO—, —SO 2 —, —NR 7 —, —SO 2 NR 7 —, or —NR 7 SO 2 —, —NR 7 SO 2 NR 7 —; m and n are each independently selected from zero or one; R 2 is selected from hydrogen, CN, halogen, R, N(R 7 ) 2 , OR, or OH; each R 3 is independently selected from R 7 , F, Cl, —(CH 2 ) y N(R 7 ) 2 , —N(R 7 ) 2 , —OR 7 , —SR 7 , —NR 7 C(O)R 7 , —NR 7 C(O)N(R 7 ) 2 , —C(O)N(R 7 ) 2 , —SO 2 R 7 , —NR 7 SO 2 R 7 , —C(O)R 7 , —C(O)R 7 , CN or —SO 2 N(R 7 ) 2 ; R 4 is selected from —(CH 2 ) y R 6 , —(CH 2 ) y CH(R 6 ) 2 , —(CH 2 ) y CH(R 8 )CH(R 6 ) 2 , —N(R 5 ) 2 , —NR 5 (CH 2 ) y N(R 5 ) 2 ; each R is independently selected from an optionally substituted group selected from C 1-6 aliphatic, C 6-10 aryl, heteroaryl having 5-10 ring atoms, and heterocyclyl having 3-10 ring atoms; each R 5 is independently selected from R, —R 7 , —C(O)R 7 , —CO 2 R, —C(O)N(R 7 ) 2 , —SO 2 R 7 , —(CH 2 ) y R 6 , or —(CH 2 ) y CH(R 6 ) 2 ; y is 0-6; each R 6 is independently selected from R, —(CH 2 ) y R, —OR, —CO 2 R, —(CH 2 ) y N(R 7 ) 2 , —N(R 7 ) 2 , —OR 7 , —SR 7 , —NR 7 C(O)R 7 , —NR 7 C(O)N(R 7 ) 2 , —C(O)N(R 7 ) 2 , —SO 2 R 7 , —NR 7 SO 2 R 7 , —C(O)R 7 , —CN, —SO 2 N(R 7 ) 2 ; each R 7 is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or two R 7 on the same nitrogen are taken together with the nitrogen to form a 5-8 membered ring heterocyclyl or heteroaryl ring; each R 8 is independently selected from R, —(CH 2 ) w OR 7 , —(CH 2 ) w N(R 5 ) 2 , or —(CH 2 ) w SR 7 ; and each w is independently 0-4.