Patent ID: 7199123

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or hydrate thereof where: R 1 is H; R 2 is a substituted or unsubstituted (C 6 –C 8 )alkyl, (C 3 –C 9 )cycloalkyl, (C 3 –C 9 )cycloalkyl(C 1 –C 8 ) alkyl, (C 3 –C 9 )aryl, (C 3 –C 9 )aryl(C 1 –C 8 )alkyl, (C 3 –C 9 )heteroaryl, (C 3 –C 9 )heteroaryl(C 1 –C 8 ) alkyl, (C 6 –C 8 )hydroxyalkyl, (C 3 –C 9 )heterocyclyl, (C 3 –C 9 )heterocyclyl(C 1 –C 8 )alkyl, (C 1 –C 8 )alkyl(C 3 –C 9 )aryl, (C 1 –C 8 )alkylamine, (C 1 –C 8 )alkylamide; or R 1 and R 2 taken together with the nitrogen to which they are attached form a substituted or unsubstituted (C 3 –C 9 ) heterocyclyl or heteroaryl; R 3 is independently selected from the group consisting of H, (C 1 –C 8 alkyl, halo, (C 1 –C 8 )alkoxy, (C 1 –C 8 )alkyl-SO 2 —, cyano, and (C 1 –C 8 )alkylC(═O)—; n is an integer from 0–5; wherein “substituted” refers to one or more substitutions with a substituent selected from the group consisting of cycloalkyl, heterocyclyl, hydroxyalkyl, benzyl, carbonyl, halo, haloalkyl, perfluoroalkyl, perfluoroalkoxy, alkyl, alkenyl, alkynyl, hydroxy, oxo, mercapto, alkylthio, alkoxy, —O—(C 1 –C 6 )alkyl, aryl or heteroaryl, aryloxy or heteroaryloxy, aralkyl or heteroaralkyl, aralkoxy or heteroaralkoxy, HO—(C═O)—, amido, amino, alkyl- and dialkylamino, cyano, nitro, carbamoyl, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylcarbonyl, aryloxycarbonyl, alkylsulfonyl, and arylsulfonyl; with the proviso that the compound is not 3-amino-6-phenyl-pyrazine-2-carboxylic acid butylamide or 3-amino-6-phenyl-pyrazine-2-carboxylic acid (2-hydroxy-ethyl)-amide.