Patent ID: 8569259

Claim:
A compound of formula IA: or enantiomers, diastereomers, enantiomerically enriched mixtures, racemic mixtures, crystalline forms, non-crystalline forms, amorphous forms, or pharmaceutically acceptable salts thereof, wherein: Ar is an aryl, alkyl, cycloalkyl, aralkyl, or a heteroaryl or fused heteroaryl group containing 1-4 heteroatoms; each of which is optionally substituted with one or more of a halo, hydroxy, alkyl, alkoxy, carboxy, cyano, nitro, sulfonamido, sulfonate, amino, imino, alkylamino, or di-alkylamino group or groups; provided that when X is O, Ar is neither unsubstituted phenyl, anilino, nor 4-nitrophenyl; X is a bond or is selected from the group consisting of O, S, S(O), S(O 2 ), N(R′), —C(O)N(R′)—, and —(CH 2 )mX 1 —; X 1 is O, S, S(O), S(O 2 ), or N(R′); R′ is H, alkyl, or aralkyl; Q is selected from the group consisting of H; OH; lower alkoxy; halo; mono-, di- or trihalomethyl; amino; lower alkylamino; and lower dialkylamino group; U and V each represent independently for each occurrence O; NH; a lower alkylamino diradical; methylene; or mono- or dihalomethylene; Y 1 , Y 2 , and Y 3 each represent independently for each occurrence O − , S − ; or substituted or unsubstituted lower alkoxy, aryloxy, aralkyloxy, or cycloalkyloxy groups; Z is O, NH, or a lower alkylamino diradical; m and n are independently 0, 1 or 2; W is P.