Patent ID: 8822485

Claim:
A compound of Formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein A is a 5- or 6-membered aryl or heteraryl ring; each of B 1 , B 2 and B 3 , independently, is N, —CF, —CCH 3 or CH; L is —CR 2 R 2 —(CR 3 R 3 )—, —CR 2 R 2 —O—, —CR 2 ═CR 3 —, —C═C—, C 3-8 cycloalkyl, tetrahydrofuranyl or tetrahydropyranyl, wherein the C 3-8 cycloalkyl, tetrahydrofuranyl and tetrahydropyranyl are optionally substituted with 1-4 substituents of R 4 , and wherein each R 2 , independently, is H, C 1-3 alkyl or F; and each R 3 , independently, is H, C 1-6 alkyl, C 3-6 cycloalkyl, —OH, —OC 1-4 alkyl, halo, haloalkyl, CN, —NH 2 or —NHC 1-6 alkyl; each R 1 independently, is F, Cl, Br, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, —S(O) n C 1-6 -alkyl, —NH 2 , CN, —NHC 1-6 -alkyl, —C(O)C 1-6 -alkyl, —C(O)-cycloalkyl or —C(O)NR a R b wherein R a is H or C 1-6 alkyl and R b is R 4 ; alternatively, R a and R b taken together with the nitrogen atom to which they are attached form a 4-7 membered monocyclic heterocycle, wherein the cycloalkyl of the —C(O)-cycloalkyl and monocyclic heterocycle are optionally substituted with 1-3 substituents of R 4 ; each R 4 , independently, is halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, oxo, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a fully saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, haloalkoxyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -thioalkoxyl, benzyl or phenyl; Z is a 6-membered monocyclic or 10-membered bicyclic aryl ring or 5- or 6-membered monocyclic or 9-10-membered bicyclic heteraryl ring; m is 0, 1, 2, 3, 4 or 5; n is 0, 1 or 2; and p is 0, 1, 2, 3, 4 or 5.