Patent ID: 8795690

Claim:
A composition comprising a first protective protein and a second protective protein, i) wherein the first protective protein consists of the amino acid sequence of SEQ ID NO: 5 (gbs1478p) or functionally active protein that consists of at least 95% identity to the sequence of SEQ ID NO:5; and wherein the functionally active protein shows at least 80% of the protection shown for the protective protein of SEQ ID NO: 5 against challenge with at least one strain of S. agalactiae used in a dose of 10 6 -10 8 cfu in a lethal sepsis model, wherein the strain is selected from the group consisting of C388/90, A909, ATCC12401, ATCC1243, COH1, BAA22, BAA23, 2603V/R, and ATCC49447; ii) wherein the second protective protein consists of the amino acid sequence of SEQ ID NO: 6 (gbs2018p) or functionally active protein that consists of at least 95% identity to the sequence of SEQ ID NO: 6; and wherein the functionally active protein shows at least 80% of the protection shown for the protective protein of SEQ ID NO: 6 against challenge with at least one strain of S. agalactiae used in a dose of 10 6 -10 8 cfu in a lethal sepsis model, wherein the strain is selected from the group consisting of C388/90, A909, ATCC12401, ATCC1243, COH1, BAA22, BAA23, 2603V/R, and ATCC49447.