Patent ID: 7855295

Claim:
A compound having the formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, or ester thereof, wherein R 1 is selected from the group consisting of (1) hydrogen, and (2) substituted or unsubstituted C 1 -C 6 alkyl; R 2 is substituted or unsubstituted aryl; R 3 is hydrogen; R 4 is a nitrogen-containing group, wherein the nitrogen-containing group is selected from the group consisting of amino alkyl, amine, cyclic amine, carbamate, amide, and sulfonamide groups; R 5 is selected from the group consisting of (1) hydrogen, (2) CO 2 R 5a , and (3) CONR 5b R 5c , wherein R 5a , R 5b , and R 5c are selected from the group consisting of (a) substituted or unsubstituted alkyl, and (b) substituted or unsubstituted aryl; R 6 is hydrogen; R 7 is hydrogen or hydroxy; R 8 is hydrogen, or R 7 and R 8 taken together with the carbon atom to which R 7 and R 8 are attached form a carbonyl; R 10 is selected from the group consisting of (1) substituted or unsubstituted aryl, (2) halogen, and (3) OR 10a , wherein R 10a is selected from the group consisting of (a) hydrogen, (b) substituted or unsubstituted alkyl, and (c) substituted or unsubstituted aryl; and R 9 , R 11 , and R 12 are selected from the group consisting of (1) hydrogen, (2) substituted or unsubstituted alkyl, and (3) halogen, wherein the term “substituted” refers to the replacement of hydrogen with a radical selected from a group consisting of hydroxyl, halo, alkoxy, cyano, sulfide, sulfonamido, oxo, carboxyl, alkyl, haloalkyl, alkylcarbonyl, aminocarbonyl, amino, and alkylamino.