Patent ID: 8465751

Claim:
A Cna_B domain antigen selected from the group consisting of: (a) a Cna_B domain antigen comprising the amino acid sequence SEQ ID NO:5, wherein amino acid 1 of SEQ ID NO:5 is not linked by a peptide bond to amino acid 311 of SEQ ID NO:21 and/or amino acid 70 of SEQ ID NO:5 is not linked by a peptide bond to amino acid 382 of SEQ ID NO:21; (b) a Cna_B domain antigen which consists of the amino acid sequence SEQ ID NO:5 and 307, 308, 309, or 310 additional contiguous amino acids of SEQ ID NO:21 at the N terminus of SEQ ID NO:5; and (c) a Cna_B domain antigen which consists of the amino acid sequence SEQ ID NO:5 and 307, 308, 309, or 310 additional contiguous amino acids of SEQ ID NO:21 at the N terminus of SEQ ID NO:5 and 0-380 additional contiguous amino acids of SEQ ID NO:21 at the C terminus of SEQ ID NO:5, and wherein the Cna B domain antigen is not a native gram positive bacterial protein, SEQ ID NO:21.