Patent ID: 7351855

Claim:
A conjugate formable by the conjugation of at least one biologically active molecule and a valency platform having the formula: Q 1 -(CH 2 CH 2 O) n CH 2 CH 2 -Q 1 wherein each Q 1 is a chemical moiety independently selected from the group consisting of: wherein each Q 2 is a chemical moiety of the formula: wherein each Q 3 is a chemical moiety independently selected from the group consisting of: wherein each T is a chemical moiety independently selected from the group consisting of: wherein: n is an integer from 0 to 300; m is in integer from 1 to 10; p is independently selected from an integer from 1 to 10; each X is independently a halogen of atomic number greater than 16 and less than 54 or other good leaving group; each R ALK is independently a linear, branched, or cyclic alkyl group of 1 to 20 carbon atoms; each R SUB is independently H, a linear, branched, or cyclic alkyl group of 1 to 20 carbon atoms, an aryl group of 6 to 20 carbon atoms, or an alkaryl group of 7 to 30 carbon atoms; each R ESTER is independently N-succinimidyl, p-nitrophenyl, pentafluorophenyl, tetrafluorophenyl, tetrachlorophenyl, 2,4,5-trichlorophenyl, 2,4-dinitrophenyl, cyanomethyl, or other activating group; and each R B is independently a chemical moiety comprising 1 to 50 atoms selected from the group consisting of C, H, N, O, Si, P, and S; and the conjugate optionally comprises a linker moiety linking the biologically active molecule to the valency platform molecule.