Patent ID: 7736624

Claim:
A cyclooxygenase-2-selective therapeutic and/or diagnostic agent of the following structural formula: wherein: R 1 =C 1 to C 6 alkoxy, C 1 to C 6 branched alkoxy, or halo-substituted versions thereof; R 2 =benzoyl or halo-substituted benzoyl; X is an active agent selected from the group consisting of a chemotherapeutic agent; a fluorophore selected from the group consisting of dansyl chloride, dabsyl chloride, nitrobenzodiazolamine (NBD), fluorescein and derivatives thereof, rhodamine and derivatives thereof; a cyanine dye; and a near infrared (NIR) dye; and A is an alkylamide tether selected from the group consisting of an alkyldiamide tether, an alkylamidodiester tether, an alkyldiamidomonoester tether, an alkylamidosulfonamide tether, an alkylamidothiourea tether, an alkyldiamidosulfonamide tether, and an aminoalkyldiamide tether; B is —NH; and n is 1.