Patent ID: 7476742

Claim:
A compound of Formula (I), wherein R and R 1 is H or C 1 -C 6 alkyl; R 2 is H, C 1 -C 6 alkyl, or phenyl which may be unsubstituted or substituted with R 3 ; R 3 is H, halo, NO 2 , CF 3 , 2,3-methylenedioxy, 3,4-methylenedioxy, C 1 -C 6 alkylthio, C 1 -C 6 alkyl optionally substituted with oxo or hydroxy, C 1 -C 6 alkoxy optionally substituted with fluoro, or —COOH or —COOC 1 -C 6 alkyl. R 4 is NH(Y—R 6 ) or N(Y—R 6 ) 2 ; Y is a bond, —SO 2— —, or —C(O)—; R 6 is H, aryl, benzyl, C 1 -C 6 alkoxyalkyl, C 1 -C 6 alkyl, or heteroaryl, each of which can be substituted by R 3 , or when Y is a bond, two R 6 groups may form, together with the N atom to which they are attached, a 3-7 membered heterocyclic ring optionally containing an additional N, S, or O atom, which is optionally substituted by N(R 7 ) 2 or N + (R 5 ) 3 , and R 5 is C 1 -C 6 alkyl optionally substituted with phenyl, R 7 is H, C 1 -C 6 alkyl or phenyl substituted with R 3 ; and X is O; or a pharmaceutically acceptable salt or ester thereof.