Patent ID: 7883696

Claim:
A method of increasing the production of one or more gene products of interest in a cell or tissue, comprising the step of administering to said cell or tissue a genetically engineered bacterium comprising nucleic acid sequences encoding: i) said one or more gene products of interest and ii) one or more factors that inhibit a mammalian type I interferon response, wherein said nucleic acid sequences encoding said one or more gene products of interest are operably linked to a eukaryotic promoter, and said nucleic acid sequences encoding said one or more factors that inhibit a mammalian type I interferon response are operably linked to a eukaryotic promoter or a prokaryotic promoter, and wherein said step of administering is carried out under conditions which allow said genetically engineered bacterium to invade said cell or tissue, and which allow said cell or tissue to produce said one or more gene products of interest.