Patent ID: 8868393

Claim:
A computer implemented method of automatically classifying microarray data of a patient sample, the method comprising: receiving microarray data representing a plurality of probes on a microarray; automatically generating a plurality of expression signals based on the microarray data; applying, by a computer system, a first classification model for a classification scheme having a plurality of classes to at least a portion of the expression signals to produce a first preliminary call, the first preliminary call identifying the patient sample as belonging to one or more first classes of the plurality of classes; applying, by the computer system, a second classification model for the classification scheme to the at least a portion of the expression signals to produce a second preliminary call, the second preliminary call identifying the patient sample as belonging to one or more second classes of the plurality of classes; combining, by the computer system the first and second preliminary calls to produce a combined call and a weight, the combined call identifying the patient sample as belonging to one class of the plurality of classes, the weight corresponding to the one class; and determining, by the computer system: whether the weight exceeds a threshold value, and if not, returning an Indeterminable Call, and if so: comparing the combined call with a verifier to determine consistency, and if the combined call is not consistent with the verifier, returning an Indeterminable Call, and if the combined call is consistent with the verifier, returning the combined call.