Patent ID: 8338565

Claim:
A compound represented by formula VII: including pharmaceutically acceptable salts thereof, wherein: R 50 is benzyl, phenylethyl, indol-3-ylmethyl, thien-2-ylmethyl, biphenyl -4-ylmethyl, 4-(pyridin-4-yl)benzyl, 4-(pyridin-3-yl)benzyl, or 4-(pyridin-2-yl)benzyl, wherein the benzyl, biphenyl-4-yl or phenylethyl group in R 50 is optionally substituted on a terminal phenyl ring with a single substituent selected from the group consisting of halo, methoxy, CF 3 , hydroxy, cyano, and C 1 -C 4 alkyl; or is optionally substituted with chloro at each of the 2 and 4 positions of the terminal phenyl ring; R 51 is biphenyl-4-ylmethyl, 4-(pyridin-4-yl)benzyl, or 4-(pyridin-3-yl)benzyl, wherein the biphenyl group in R 51 is optionally monosubstituted at the 4-position of the terminal phenyl ring with amino, halo or hydroxy; R 52 is phenyl, naphthyl, benzyl, naphthylmethyl, phenylethyl, heteroarylmethyl, 4-(heteroaryl)benzyl, or biphenyl-4-ylmethyl, wherein the phenyl, naphthyl, benzyl, naphthylmethyl, phenylethyl or biphenyl-4-ylmethyl group in R 52 is optionally on a terminal phenyl ring with 1 to 2 substituents independently selected from the group consisting of halo, methoxy, hydroxy, C 1 -C 4 alkyl, and C 1 -C 4 haloalkyl; R 53 is hydrogen or methyl; X is —OH, —N(R W )—[C(R V ) 2 ] 1-4 —COOH, —N(R W )—[C(R V ) 2 ] 1-3 —SO 3 H, —N(R W )—[C(R V ) 2 ] 0-4 —S(O) 2 CH 3 , or —N(R W )—[C(R V ) 2 ] 1-3 -1H-tetrazol-5-yl, wherein: R W represents hydrogen, methyl or benzyl; and each R V independently represents hydrogen, —(C 1 -C 6 )-alkyl, —(C 1 -C 6 )-alkyl-heterocyclyl, —(C 1 -C 6 )-alkyl-carbocyclyl, or —CO 2 -alkyl, wherein each R V is optionally substituted with a substituent selected independently from the group consisting of —NH 2 , —NH—C(O)—(C 1 -C 4 )-alkyl and —OH; or two R V are taken together with the carbon atom to which they are bound to form a 3-7 membered cycloalkane ring, the stereochemistry at (1) is the same as the stereochemistry at (3); and the stereochemistry at (1) is opposite the stereochemistry at (2).