Patent ID: 7456008

Claim:
A modified adenovirus comprising one or more non-native polypeptides, each polypeptide comprising one or more framework moieties which possess a folded three dimensional structure, each framework moiety containing one or more binding moieties, wherein each framework moiety is derived from an antibody or a bacterial receptor, said polypeptide forming part of a recombinant adenoviral fiber protein and being capable of being expressed in a cytoplasm and a nucleus of a mammalian host cell, wherein said polypeptide folds in a conformation which is maintained in the absence of a ligand for said binding moieties, said conformation allowing said binding moieties to bind with said ligand and wherein said conformation does not rely on di-sulphide bonding for its conformation when expressed in the mammalian host cell cytoplasm, and said polypeptide being capable of transport through a nuclear membrane, wherein said modified adenovirus has an altered tropism conferred by said binding moieties.