Patent ID: 7365061

Claim:
A compound of formula I or stereoisomers or pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen and R 2 is substituted alkyl, OR 7A , OCONR 7A R 7B , CN, tetrazole substituted with R 7A , CO 2 R 7A , CONR 7A R 7B or NR 7A COCO 2 R 7B ; R 7A and R 7B are hydrogen or alkyl; X and Y are —CH 2 —; W is A is —CH—; Z is R 3 and R 4 are each independently hydrogen, halo, trifluoromethyl, cyano, alkyl or alkoxy; and R 5 and R 6 are each independently hydrogen, halo, trifluoromethyl, cyano, hydroxy, OR 7A , OCO 2 R 8 , OCONR 7A R 7B , NO 2 , CN 4 R 7A , COCF 3 , COR 7A , CO 2 R 7A , CONR 7A R 7B , CONR 7A OR 7B , C(NR 7A )NR 7B R 7C , CONR 7A SO 2 R 7B , SOR 8 , SO 2 R 8 , SO 3 H, SO 2 NR 7A R 7B , SO 2 NR 7A COR 7B , SO 2 NR 7A CONR 7B R 7C , POR 7A R 7B , PO 2 R 7A R 7B , PO 3 R 7A R 7B , PO 2 R 7A NR 7B R 7C , NR 7A R 7B , NR 7A COR 7B , NR 7A C(NR 7B )R 7C , NR 7A CO 2 R 8 , NR 7A COCO 2 R 7B , NR 7A CONR 7B R 7C , NR 7A C(NR 7B )NR 7C R 7D , NR 7A SO 2 R 7B , NR 7A CONR 7B SO 2 R 7C , NR 7A SO 2 NR 7B R 7C , NR 7A POR 7B R 7C , NR 7A PO 2 R 7B R 7C , NR 7A PO 3 R 7B R 7C , NR 7A PO 2 R 7B NR 7C R 7D , —O—, —CO—, —SO 2 —, —NR 7A —, —CO 2 —, —CONR 7A —, —SO 2 NR 7A —, —OCONR 7A —, —NR 7A CONR 7B —, —N(COR 7A )—, —N(CO 2 R 7A )—, —N(CONR 7A R 7B )—, —N(SO 2 NR 7A R 7B )—, alkyl, aryl, arylalkyl, heteroarylalkyl, alkoxy, aryloxy or alkenyl.