Patent ID: 8871797

Claim:
A method for modulating the activity of a 5HT 2A serotonin receptor by contacting the receptor with a compound of Formula (IIa): or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein: R 1 is phenyl or naphthyl optionally substituted with R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , and R 15 each selected independently from the group consisting of C 1-6 acyl, C 1-6 alkoxy, C 1-6 alkyl, amino, C 1-6 alkylamino, C 2-8 dialkylamino, C 1-6 alkylimino, cyano, halogen, C 1-6 haloalkoxy, C 1-6 haloalkyl, heterocyclic, hydroxyl, nitro, and phenyl, or two adjacent R 9 , R 10 , R 11 , R 12 , R 13 , R 14 and R 15 together with the atoms to which the are attached form a C 5-7 cycloalkyl group or heterocyclic group each optionally substituted with F; and wherein said C 1-6 alkyl, C 1-6 alkylimino, and heterocyclic are each optionally substituted with 1 to 5 substituents selected independently from the group consisting of C 1-6 alkyl, amino, C 1-6 alkylamino, C 2-8 dialkylamino, and hydroxyl; R 2 is C 1-6 alkyl; R 3 is H or halogen; R 4 is selected from the group consisting of H, C 1-6 alkyl and C 1-6 haloalkyl; R 6 is selected from the group consisting of C 1-6 alkoxy, C 1-6 haloalkoxy, and hydroxyl, wherein said C 1-6 alkoxy group is optionally substituted with 1 to 5 further substituents selected independently from the group consisting of amino C 2-8 dialkylamino, carboxy, and phenyl, and wherein said amino and phenyl are each optionally substituted with 1 to 5 further substituents selected from the group consisting of halogen and carbo-C 1-6 -alkoxy; R 6a , R 6b , and R 6c are each independently selected from the group consisting of H, C 1-6 alkoxy, C 1-6 alkyl, amino, C 1-6 alkylamino, C 2-8 dialkylamino, cyano, halogen, C 1-6 haloalkoxy, C 1-6 haloalkyl, hydroxyl, and nitro; R 7 and R 8 are both H; X is O; and Q is a bond.