Patent ID: 8088792

Claim:
A compound that is an inhibitor of stearoyl-CoA desaturase having the structure of Formula I: wherein R 1 is hydrogen, optionally substituted C 1-20 alkyl, optionally substituted C 1-6 lower alkyl, optionally substituted C 3-20 cycloalkyl, optionally substituted C 2-20 alkenyl, optionally substituted C 2-20 alkynyl, optionally substituted C 1-20 alkoxy, optionally substituted monocyclic aryl, or optionally substituted monocyclic heteroaryl; R 2 is hydrogen, optionally substituted C 1-20 alkyl, optionally substituted C 1-6 lower alkyl, optionally substituted C 3-20 cycloalkyl, optionally substituted C 2-20 alkenyl, optionally substituted C 2-20 alkynyl, optionally substituted C 1-20 alkoxy; X is a moiety selected from: —O—C(O)—, —NR′—C(O)—, —C(O)—NR′—, or —O—C(O)—NR′—, wherein R′ is hydrogen or C 1-6 lower alkyl; L 1 is a covalent bond or -Lk-Y—, wherein Lk is optionally substituted linear or branched C 1-4 alkylene and Y is selected from a covalent bond, —O—, —S—, or —NR″—, wherein R″ is hydrogen or C 1-6 lower alkyl; and L 2 is a covalent bond or -Lk′-Y′—, wherein Lk′ is optionally substituted linear or branched C 1-4 alkylene and Y′ is selected from a covalent bond, —O—, —S—, or —NR″—, wherein R″ is hydrogen or C 1-6 lower alkyl with the proviso that R 1 is not hydrogen when L 1 is a bond.