Patent ID: 7470783

Claim:
A method of attaching a molecule with a reactive site to a support comprising the steps of: (a) providing a support with a reactive site; (b) binding a first molecule to the reactive site, said first molecule comprising a masked reactive site attached to a photolabile protecting group of the formula Ar—C(R 1 )(R 2 )—O—C(O)—, wherein: Ar is an optionally substituted fused polycyclic aryl or heteroaromatic group or a vinylogously substituted derivative of the foregoing; R 1 and R 2 are independently H, optionally substituted alkyl, alkenyl or alkynyl, or optionally substituted aryl or heteroaromatic group or a vinylogously substituted derivative of the foregoing; to produce a derivatized support having immobilized thereon the molecule attached to the photolabile protecting group; and (c) removing the photolabile protecting group to provide a derivatized support comprising the first molecule with an unmasked reactive site immobilized thereon, wherein said removing is carried out in the presence of a nucleophilic solvent.