Patent ID: 8158663

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein X is S; R 1 is phenyl substituted with 1, 2, 3, 4, or 5 substituents as represented by N, R j at each occurrence is independently alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylsulfinyl, alkylsulfinylalkyl, alkyl-S(O) 2 —, alkyl-S(O) 2 -alkyl-, cyanoalkyl, formyl, ═N—O(alkyl), ═N—OH, alkylthio, alkylthioalkyl, alkynyl, carboxy, carboxyalkyl, cyano, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, nitro, R h R k —N—, (R m R n N)carbonyl, cycloalkyloxy, cycloalkylalkoxy, or cycloalkyl; R 2 is n-butyl, sec-butyl, iso-butyl, tert-butyl, n-pentyl, isopentyl (3-methylbutyl), neopentyl, n-hexyl, 3-methylhexyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, n-heptyl, n-octyl, n-nonyl, n-decyl, alkoxy-(C 2 -C 6 alkylene)-, alkoxyalkoxy-(C 2 -C 6 alkylene)-, alkenyl, alkynyl, cycloalkylalkyl, cycloalkyloxyalkyl, cycloalkylalkoxyalkyl, cyanoalkyl, nitroalkyl, haloalkyl, haloalkoxyalkyl, hydroxyalkyl, R a R b N—(C 2 -C 6 alkylene)-, R c S—(C 2 -C 6 alkylene)-, R c —SO 2 -alkylene-, R c —C(O)-alkylene-, R d C(═N—OR f )—(C 2 -C 6 alkylene)-, R d R e N—SO 2 -alkylene-, or R d R e N—C(O)-alkylene-; R 3 and R 4 are each independently hydrogen, alkyl, cycloalkyl, haloalkyl, or hydroxyalkyl or R 3 and R 4 taken together with the carbon atom to which they are attached form a monocyclic cycloalkyl; R 5 and R 6 are each independently hydrogen, alkyl, aryl, cycloalkyl, haloalkyl, or hydroxyalkyl; or R 5 and R 6 taken together with the carbon atom to which they are attached form a monocyclic cycloalkyl ring; or R 3 and R 5 taken together with the atoms to which they are attached form a monocyclic cycloalkyl; R a and R b , at each occurrence, are each independently hydrogen, alkyl, haloalkyl, alkylcarbonyl, alkylsulfonyl, aryl, arylcarbonyl, arylsulfonyl, or cycloalkyl; R c , at each occurrence, is independently alkyl, haloalkyl, aryl, or arylalkyl; R d and R e , at each occurrence, are each independently hydrogen, alkyl, haloalkyl, aryl, or arylalkyl; R f is hydrogen, alkyl, or haloalkyl; R h and R k , at each occurrence, are each independently hydrogen, alkyl, haloalkyl, alkylcarbonyl, alkylsulfonyl, aryl, arylcarbonyl, arylsulfonyl, or cycloalkyl; and R m and R n , at each occurrence, are each independently hydrogen, alkyl, haloalkyl, aryl, or arylalkyl.