Patent ID: 7838673

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or boronic acid anhydride thereof, wherein: P is R d —C(O)—, R d —O—C(O)—, R d —N(R 4x )—C(O)—, R d —S(O) 2 —, or R d —N(R 4x )—S(O) 2 —; R d is selected from the group consisting of C 1-6 aliphatic, C 1-6 fluoroaliphatic, —R D , -T 1 —R D , and -T 1 —R 2d ; T 1 is a C 1-6 alkylene chain substituted with 0-2 independently selected R 3a or R 3b , wherein the alkylene chain optionally is interrupted by —C(R 5 )═C(R 5 )—, —C≡C—, or —O—; R D is a substituted or unsubstituted aromatic, heterocyclyl, or cycloaliphatic ring, any of which is optionally fused to a substituted or unsubstituted aromatic, heterocyclyl, or cycloaliphatic ring; R 2d is halo, —OR 5 , —SR 6 , —S(O)R 6 , —SO 2 R 6 , —SO 2 N(R 4 ) 2 , —N(R 4 ) 2 , —NR 4 C(O)R 5 , —NR 4 C(O)N(R 4 ) 2 , —NR 4 CO 2 R 6 , —N(R 4 )SO 2 R 6 , —N(R 4 )SO 2 N(R 4 ) 2 , —O—C(O)R 5 , —OC(O)N(R 4 ) 2 , —C(O)R 5 , —CO 2 R 5 , or —C(O)N(R 4 ) 2 ; each R 3a independently is selected from the group consisting of —F, —OH, —O (C 1-4 alkyl), —CN, —N(R 4 ) 2 , —C(O)(C 1-4 alkyl), —CO 2 H, —CO 2 (C 1-4 alkyl), —C(O)NH 2 , and —C(O)—NH(C 1-4 alkyl); each R 3b independently is a C 1-3 aliphatic optionally substituted with R 3a or R7; each R 4 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; or two R 4 on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms independently selected from N, O, and S; each R 5 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; each R 6 independently is an optionally substituted aliphatic, aryl, or heteroaryl group; each R 7 is a substituted or unsubstituted aromatic group; and R 4x is hydrogen, C 1-4 alkyl, C 1-4 fluoroalkyl, or C 6-10 ar(C 1-4 )alkyl, the aryl portion of which is substituted or unsubstituted; R a is a C 1-4 aliphatic or C 1-4 fluoroaliphatic group that is substituted with 0-1 R A ; or R a and R b taken together with the carbon atom to which they are attached, form a substituted or unsubstituted 3- to 6-membered cycloaliphatic group; R A is a substituted or unsubstituted aromatic or cycloaliphatic ring; R b is a C 1-4 aliphatic or C 1-4 fluoroaliphatic group; or R a and R b , taken together with the carbon atom to which they are attached, forma substituted or unsubstituted 3- to 6-membered cycloaliphatic group; R c is a C 1-4 aliphatic or C 1-4 fluoroaliphatic group that is substituted with 0-1 R c ; R c is a substituted or unsubstituted aromatic or cycloaliphatic ring; and Z 1 and Z 2 are each independently hydroxy, alkoxy, aryloxy, or aralkoxy; or Z 1 and Z 2 together form a moiety derived from a boronic acid complexing agent.