Patent ID: 7202269

Claim:
A compound of formula (I): wherein, R 1 and R 2 are independently selected from the group consisting of H, C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl and benzyl, or alternatively R 1 and R 2 taken together with the nitrogen atom to which they are attached form a pyrrolidinyl or piperidinyl ring optionally substituted with 1–3 independently selected C 1-6 alkyl substituents; R 3 is H or C 1-6 alkyl, optionally substituted with NH 2 ; n is 2, 3, 4 or 5; m is 0 or 1; Y 1 is a covalent bond, C 1-4 alkane-diyl, or cis or trans C 2-4 alkene-diyl, optionally substituted with 1 or 2 independently selected C 1-4 alkyl substituents; R 4 is H, C 1-4 alkyl or phenyl; R 5 is selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 3-7 cycloalkyl, phenyl, thienyl, benzhydryl and —Y 3 -R a , where Y 3 is C 1-3 alkane-diyl or C 2-3 alkene-diyl, and R a is selected from the group consisting of C 3-7 cycloalkyl, phenyl, naphthyl, biphenyl, benzylsulfanyl, benzyloxy, thienyl, furyl, thiazolyl, oxazolyl, imidazolyl, 1H-indol-2-yl, 1H-indol-3-yl and pyridyl; or alternatively R 4 and R 5 taken together with the carbon atom to which they are attached form a 3- to 7-membered monocyclic carbocyclyl ring, optionally benzofused; where R 5 is substituted at any stable position except Y 3 with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, sulfanyl, halo, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, C 1-4 alkylsulfanyl, carboxy, amino and carbamoyl, and Y 3 is substituted with 0, 1 or 2 substituents independently selected from the group consisting of fluoro, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy and amino; or alternatively R 4 and R 5 taken together is substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, halo, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy and amino; R 6 is H or C 1-4 alkyl; X is selected from the group consisting of >C═O, >C═S, >C═N—CN and >C═CHNO 2 ; Y 2 is a covalent bond or methylene; R 7 is H, halo or C 1-4 alkyl; R 8 is selected from the group consisting of H, phenyl, —O-phenyl, —O-tetrahydronaphthyl, —SO 2 -phenyl, thienyl and pyridyl; or alternatively R 7 and R 8 taken together with the phenyl to which they are attached form fluorenyl or tetrahydronaphthyl; where R 8 , or R 7 and R 8 taken together, is substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, cyano, nitro, amino, dimethylamino, halo, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, —(CO)—C 1-4 alkyl and —(SO 2 )—C 1-4 alkyl; and stereoisomers, solvates, pharmaceutically acceptable salts, thereof.