Patent ID: 6946478

Claim:
A compound of general formula wherein: R 1 represents a 3- to 10-membered saturated or unsaturated monocyclic ring system containing up to two ring carbon atoms that form carbonyl groups and which comprises 1,2,3 or 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur, the ring system being optionally substituted by one or more substituents independently selected from halogen atoms, and cyano, nitro, hydroxyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, —NR 5 R 6 , C 3 -C 6 cycloalkylamido, C 1 -C 6 alkylthio, C 1 -C 6 alkylthio C 1 -C 6 alkyl, C 1 -C 6 alkylcarbonylamino, —C(O)NR 7 R 8 , sulphonamido, (di)C 1 -C 6 alkylsulphonamido, phenyl, phenylamino, nitrophenyl, pyridyl, pyridylthio, benzodioxanyl, thienyl, furanyl, and C(O)R 9 -substitutcd C 1 -C 6 alkyl or C 1 -C 6 alkoxy groups; m is 0 or 1; Q represents a group OCH 2 , C 1 -C 6 alkylene or C 2 -C 4 alkenylene; T represents a group C(O)NH, or when m is 0 and R 1 is not optionally substituted pyridinyl then T may additionally be NH, or when m is 1 and Q is C 1 -C 4 alkylene then T may additionally be NH; n is 1,2,3 or 4; each R 2 independently represents a hydrogen atom or a C 1 -C 4 alkyl group; each R 3 independently represents a hydrogen atom or a C 1 -C 4 alkyl group; V represents a nitrogen atom; W represents CH; X represents an oxygen atom or a group C(O), CH(OH), NH or N(C 1 -C 6 alkyl); R 4 represents a phenyl group optionally substituted by one or more substituents independently selected from halogen atoms, and amino, nitro, cyano, sulphonyl, sulphonamido, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy and C 1 -C 6 alkylsulphonyl groups; R 5 and R 6 each independently represent a hydrogen atom or a C 2 -C 6 alkyl or hydroxy C 1 -C 6 alkyl group, or R 5 and R 6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R 7 and R 8 each independently represent a hydrogen atom or a C 1 -C 6 alkyl group; and R 9 represents a hydroxyl or —NR 7 R 8 group; with the provisions that (a) when m is 0, T is CONH, n is 2, 3 or 4 and each R 2 and R 3 represents hydrogen, W is CH, X is C(O) or CH(OH) and R 1 represents a substituted 3- to 10-membered unsaturated ring system, then the one or more substituents in the ring system do not include hydroxyl, halogen, C 1 -C 6 alkoxy or C 1 -C 6 haloalkoxy, and (b) when X is O, n is 2 or 3 and each R 2 and R 3 represents hydrogen, m is 0 and T is NH, then R 1 does not represent a group or a pharmaceutically acceptable salt or solvate thereof.