Patent ID: 7972615

Claim:
A composition comprising: (a) a plurality of first molecules comprising: (i) a first substrate-binding peptide comprising 6 to 40 amino acids and comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 55-112, 122-123, and 138-139, wherein the first substrate is a titanium or steel medical device and the first substrate-binding peptide has binding affinity for the medical device; and (ii) a second substrate-binding peptide comprising 6 to 40 amino acids, wherein the second substrate is a vancomycin antibiotic and the second substrate-binding peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 124-126 and 131-137, and has binding affinity for the vancomycin antibiotic, wherein the first and second substrate-binding peptides are covalently linked; and (b) a plurality of second molecules comprising: the second substrate-binding peptide, wherein the second substrate-binding peptide is not covalently linked to the first substrate-binding peptide; and (c) a plurality of the target molecule, vancomycin, wherein each of the plurality of first and second molecules are covalently coupled to at least one interaction tag selected from the group consisting of a positively charged interaction tag and a negatively charged interaction tag, wherein the positively charged interaction tags interact with the negatively charged interaction tags to form a macromolecular network comprising the plurality of non-covalently coupled first and second molecules.