Patent ID: 8048889

Claim:
A compound having the Formula III: wherein: each R 1 is independently selected from alkyl, alkenyl, alkynyl, aralkyl, —O—R 11 , —N(R 12 )(R 13 ), —N(R 11 )C(O)R 11 , —N(R 11 )SO 2 R 11 , SR 11 ,—C(O)R 11 , —C(O)OR 11 , —C(O)N(R 12 )(R 13 ),—OC(O)R 11 , —OC(O)N(R 12 )(R 13 ), CN, CF 3 , NO 2 , SO 2 , —SOR 11 , —SO3R 11 , —SO 2 N(R 12)(R 13 ), -alkyl-O—R 11 , cycloalkyl, cycloalkenyl, halo, phosphate, phosphonate, and aryl; additionally or alternatively two R 1 substituents on adjacent ring atoms may be combined to form a fused 5 or 6- membered ring, wherein the fused 5 - or 6- membered ring may contain from 0 to 3 ring heteroatoms and may be further substituted with one or more substituents selected from R 1 ; each R 11 is independently selected from H, alkyl, alkyl-O-alkyl, alkyl-O-aryl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aralkyl, and aryl; each R 12 and R 13 are independently selected from H, alkyl, cycloalkyl, cycloalkenyl, alkyl-O-alkyl, alkyl-O-aryl, alkenyl, alkynyl, aralkyl, and aryl; or R 12 and R 13 may be taken together with the nitrogen to which they are attached form a 5 - to 7-membered ring which may optionally contain a further heteroatom, n is 0 to 4; R 2 is selected from the group consisting of aralkyl, aryl; R 3 is selected from the group consisting of aralkyl, aryl, —(CH 2 )aC(O)R 31 , —(CH 2 )aC(O)N(R 32 )(R 33 ), (CH 2 )aC(O)OR 31 , —(CH 2 )aC(O)N(R 32 )(R 33 ), —(CH 2 )aN(R 32 )(R 33 ), —CH═N—R 34 , R 31 selected from aralkyl, and aryl; R 32 is selected from H, alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, aralkyl, and aryl; R 33 is selected from aralkyl, and aryl; R 34 is selected from aralkyl, and aryl; a is 0 to 6; or a pharmaceutically acceptable salt thereof; with the proviso that R2 is heteroaryl or heteroaralkyl, and/or R 3 , R 31 , R 33 and R 34 are selected from heteroaryl and heteroaralkyl.