Patent ID: 8420824

Claim:
A compound of formula (VIII): wherein: Ar is selected from the group consisting of: aryl and substituted aryl R 4a is selected from the group consisting of: H and (C1-C4)alkyl; R 4b is selected from the group consisting of: H and (C1-C4)alkyl; R 5 is selected from the group consisting of: H, halogen, R 10 , CN, O(R 10 ), OC(O)(R 10 ), OS(O 2 )(R 10 ), N(R 10 )(R 11 ), N═C(R 10 )(R 11 ), N(R 10 )C(O)O(R 11 ), N(R 12 )C(O)N(R 10 )(R 11 ), N(R 12 )C(S)N(R 10 )(R 11 ), N(R 10 )S(O 2 )(R 11 ), C(O)(R 10 ), C(O)O(R 10 ), C(O)N(R 10 )(R 11 ), C(═N(R 11 ))(R 10 ), C(═N(OR 11 ))(R 10 ), S(R 10 ), S(O)(R 10 ), S(O 2 )(R 10 ), S(O 2 )O(R 10 ), S(O 2 )N(R 10 )(R 11 ); in which each R 10 , R 11 , R 12 is independently selected from the group consisting of H, alkyl, alkylene, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, substituted alkyl, substituted alkylene, substituted alkynyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl and substituted heterocyclyl; R 1 is selected from the group consisting of: H, R 6 , COR 6 , SO 2 R 6 , in which R 6 is chosen from H, OR 7 , NR 8 R 9 , alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, in which R 7 is chosen from H, phenyl and alkyl, and in which R 8 and R 9 are independently selected from the group consisting of H, alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, or alternatively R 8 and R 9 are linked together to form a saturated 5- to 8-membered ring containing from 0 to 3 heteroatoms chosen from O, S and N; X is selected from the group consisting of: O and NH; R′ 3 is R 3 or a precursor of R 3 ; and R 3 is selected from the group consisting of: H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl.