Patent ID: 7750136

Claim:
A nucleic acid encoding a modified bouganin, wherein the modified bouganin has a reduced propensity to elicit an immune response, as compared to non-modified bouganin protein (SEQ ID NO: 1), wherein the amino acid sequence of the modified bouganin protein is as set forth by: YNTVSFNLGEAYEYPTFIQDLRNELAKGTPVCQLPVTLQTIADDKRFVLV DITTTSKKTVKVAIDVTDVYVVGYQDKWDGKDRAVFLDKVPTVATSKLFP GVTNRVTLTFDGSYQKLVNAAK X 1 DRK X 2 L X 3 LGV X 4 KLEFSIEAIHGKT INGQE X 5 AKFFLIVIQMVSEAARFKYIETEVVDRGLYGSFKPNFKVLNLE NNWGDISDAIHKSSPQCTTINPALQLISPSNDPWVVNKVSQISPDMGILK FKSSK (SEQ ID NO: 11), wherein X 1 through X 5 can be any amino acid, provide that the amino acid sequence of the modified bouganin protein is not identical to the non-modified bouganin protein (SEQ ID NO: 1), wherein said modified bouganin protein inhibits protein synthesis on ribosomes.