Patent ID: 8092452

Claim:
A system for percutaneous delivery of a growth factor to a pre-drilled space in a bone of a patient comprising: (a) a threaded applicator having discontinuous threading, the threaded applicator comprising a hollow core having a total volume, and openings wherein the openings are located on the side or bottom of threaded applicator, and the threaded applicator fits into a pre-drilled space in a bone of a patient and mechanically engages with the bone; (b) a carrier comprising an effective amount of a growth factor uniformly distributed throughout the carrier, the carrier having a volume less than the total volume of the core to prevent overcrowding of the carrier in the core and the carrier is inserted into the hollow core of the threaded applicator without overstuffing of the carrier or growth factor, the carrier comprising a collagen sponge material and a compression resisting material, wherein the carrier is wrapped by a flexible sterile sheet being a size longer than the carrier, the flexible sterile sheet having a smooth surface and being more tear-resistant than the carrier, the compression resisting material and the flexible sterile sheet preventing compression of the carrier and maintaining uniform distribution of the growth factor throughout the carrier.