Patent ID: 8263651

Claim:
A method of relieving a condition selected from the group consisting of status epilepticus, other forms of epilepsy, symptoms of opiate withdrawal, insomnia, or mania in a subject in need thereof, said method comprising administering to said subject an effective amount of an agent or agents selected from the group consisting of a cis-epoxyeicosantrienoic acid (“EET”), an inhibitor of soluble epoxide hydrolase (“sEH”), and a combination of an EET and an inhibitor of sEH, wherein the inhibitor of sEH comprises a central pharmacophore comprising a urea, carbamate, or amide; and a carbamate, ester, carbonate or amide approximately 7.5 angstroms from the carbonyl of the central pharmacophore, thereby relieving said condition in said subject.