Patent ID: 8545865

Claim:
An internal medical device comprising (a) substrate having a surface region, (b) a polymer brush, and (c) a therapeutic agent disposed within or beneath said polymer brush, wherein said polymer brush comprises a block copolymer that comprises (i) a hydrophobic polymer chain selected from low glass transition temperature polyalkylene chains, low glass transition temperature poly(halogenated alkylene) chains, low glass transition temperature polysiloxane chains, low glass transition temperature polyacrylate chains and low glass transition temperature polymethacrylate chains and (ii) a low glass transition temperature polyethylene oxide hydrophilic polymer chain, wherein said polymer brush is covalently attached to said surface region, wherein said surface region has a hydrophobic surface, and wherein upon exposure of said surface region to an aqueous environment the polymer brush reorients to form a hydrophilic surface.