Patent ID: 8414525

Claim:
A balloon catheter for delivering a therapeutic agent to target site in a blood vessel, the balloon catheter comprising: a coating layer overlying an exterior surface of a balloon, the coating layer comprising a therapeutic agent and at least one first additive, wherein: the therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, and combinations thereof; and the at least one first additive comprises a PEG fatty ester selected from the group consisting of PEG laurates, PEG oleates, PEG stearates, PEG glyceryl laurates, PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan monolaurates, PEG sorbitan monooleates, PEG sorbitan stearates, PEG sorbitan laurates, PEG sorbitan oleates, PEG sorbitan palmitates, and combinations thereof; and an adherent layer between the coating layer and the exterior surface of the balloon, the adherent layer comprising a biocompatible polymer selected from the group consisting of polyolefins, polyisobutylene, ethylene-1-olefin copolymers, acrylic polymers, polyvinyl chloride, polyvinyl methyl ether, polyvinylidene fluoride, polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polystyrene, polyvinyl acetate, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, Nylon 12, polycaprolactone, epoxy resins, polyurethanes, rayon-triacetate, cellulose, cellulose acetate, cellulose butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, carboxymethyl cellulose, chitins, polylactic acid, polyglycolic acid, polylactic acid-polyethylene oxide copolymers, silicones, ethylene vinyl acetate copolymers, EPDM rubbers, and mixtures and block copolymers thereof.