Patent ID: 7584058

Claim:
A method of selecting one or more polymorphisms using a computer from a genomic region of interest for use in genotyping, comprising the steps of: a. producing an SPC map on a computer-readable medium by i. obtaining the nucleic acid sequence of said genomic region of interest from a plurality of subjects; ii. identifying using said computer a plurality of polymorphisms in said nucleic acid sequences; iii. identifying one or more SPCs using said computer, wherein each SPC comprises a subset of polymorphisms from said nucleic acid sequence wherein said polymorphisms of said subset co-segregate with each other polymorphism of said subset; and iv. assembling using a computer an SPC map of said genomic region of interest wherein said SPC map comprises a plurality of SPCs identified according to steps (i)-(iii), each SPC comprising a subset of polymorphisms from said genomic region wherein said polymorphisms of said subset co-segregates with each other polymorphism of said subset; b. selecting at least one cluster tag polymorphism which identifies a unique SPC in said SPC map; and c. selecting a plurality of cluster tag polymorphisms for use in a genotyping study of the genomic region of interest d. outputting from said computer the selected cluster tag polymorphisms obtained in step (c) into a user readable format for use in selecting a genotype or genetic marker for a trait or phenotype.