Patent ID: 7425568

Claim:
A compound of formula (I): wherein X is —O; Z is —CHR 9 —; Y is —CH 2 —, —C(O)—, CH(OR 10 )—, CH(NR 11 R 12 ); R 1 is R 2 and R 3 are independently H, lower alkyl, lower alkoxy, —NO 2 , halogen, —CF 3 , —OH, —NHR 8 or —COOH, R 6 is —NO 2 , —NR 14 R 19 , —CF 3 or R 8 is H, alkylcarbonyl, or alkenylcarbonyl, R 9 is H or lower alkyl, R 10 is H, alkylsulfonyl, alkylcarbonyl, or alkenylcarbonyl; R 11 and R 12 are independently H, lower alkyl, alkylcarbonyl, or alkenylcarbonyl, R 13 and R 18 are independently H or —OR 20 , R 14 and R 19 are independently H, alkylcarbonyl, alkenylcarbonyl, alkylsulfonyl, C(S)NHR 17 or C(O)NHR 17 , R 17 is H or lower alkyl, R 20 is H, alkylcarbonyl, or alkenylcarbonyl, or a pharmaceutically acceptable salt thereof.