Patent ID: 7592359

Claim:
Compounds defined by the structure of Formula I and their pharmaceutically acceptable salts, pharmaceutically acceptable, enantiomers, diastereomers, or N-oxides, wherein Ar represents phenyl; R 1 represents a hydrogen, hydroxy, hydroxymethyl, amino, alkoxy, carbamoyl or halogen; R 2 represents hydrogen, alkyl, C 3 -C 7 cycloalkyl ring, a C 3 -C 7 cycloalkenyl ring, or phenyl; W represents (CH 2 ) p , where p represents 0 to 1; X represents an oxygen, sulfur, —NR or no atom, wherein R represents H or alkyl; Y represents (CH 2 )q wherein q represents 0 to 1; R 3 , R 5 and R 6 are independently selected from H, lower alkyl, COOH, CONH 2 , NH 2 , CH 2 NH 2 ; and R 4 represents hydrogen, C 1 -C 15 saturated or unsaturated aliphatic hydrocarbon (straight chain or branched) in which any 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen, arylalkyl, arylakenyl, heteroarylalkyl or heteroarylalkenyl, having 1-2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms with an option that any 1 to 3 hydrogen atoms on the ring in said arylalkyl, arylalkenyl, heteroarylalkyl, heteroarylalkenyl group may be substituted with lower alkyl (C 1 -C 4 ), lower perhaloalkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ) or N-lower alkylamino carbonyl (C 1 -C 4 ).