Patent ID: 7138530

Claim:
A compound of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: Z is —S(O)— or —S(O 2 )—; R 1 is C 1-4 alkyl, halo, amino, C 1-6 alkylthio, C 2-6 alkenylthio, C 1-6 alkoxy, trifluoromethyl, methylsulfonyl, or benzylthio; Ar is phenyl, naphthyl, pyridyl, imidazolyl, thiazolyl, furanyl, thienyl, benzothiazolyl, pyrazolyl, pyrimidinyl, benzimidazolyl, benzofuranyl, indolyl, benzothiophenyl or benzo[c]chromenyl any of which is optionally substituted; R 2 , R 3 and R 4 are independently hydrogen, C 1-4 alkyl, C 6-10 aryl, C 1-4 hydroxyalkyl, C 1-4 aminoalkyl, mono(C 1-4 )alkylamino(C 2-6 )alkyl, di(C 1-4 )alkylamino(C 2-6 )alkyl, carboxy(C 1-4 )alkyl, cyano, nitro, amino, C 1-4 alkoxy, hydroxy, or BCO 2 R w , where R w is hydrogen, hydroxy, C 1-4 alkoxy, cyano, C 1-4 alkoxycarbonyl, C 1-4 alkyl, C 3-8 cycloalkyl, phenyl, benzyl, where R d and R e are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl or phenyl, R f is hydrogen, C 1-6 alkyl, C 2-6 alkenyl or phenyl, R g is hydrogen, C 1-6 alkyl, C 2-6 alkenyl or phenyl, and R h is C 6-10 ar(C 1-4 )alkyl or C 1-6 alkyl; and R 7 is hydrogen, chloro, fluoro or amino.