Patent ID: 8101431

Claim:
A system for detecting analytes in a sample comprising: (a) a cartridge, comprising a particle-based detection system and a membrane-based detection system, wherein: (i) the particle detection system is configured to produce a signal, when in the presence of an analyte, from an individual particle positioned in an individual cavity at an individually addressable position in the particle detection system and the membrane detection system is configured for analysis of microbes or cells captured on a membrane, (ii) an integrated waste reservoir that collects reagent and/or sample during use, (iii) a trap coupled to a fluid delivery system and configured to at least partially remove air from the sample, thereby reducing air bubbles within the sample, and (iv) a reagent delivery system disposed in or on the cartridge, the reagent delivery system comprising one or more reagents in a substantially sealed reservoir, and wherein the reagent delivery system is configured to deliver one or more reagents to the sample during use; and (b) an optical platform, wherein the optical platform is configured to detect a signal produced by the interaction of the sample and/or analyte with the particle detection system or the membrane detection system during use.