Patent ID: 7700552

Claim:
A compound of the formula I: and N-oxides, salts and stereoisomers thereof wherein A is OR 1 , NHS(═O) p R 2 , NHR 3 , NRaRb, C(═O)NHR 3 or C(═O)NRaRb wherein; R 1 is hydrogen, C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl; R 2 is C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl or NRaRb; R 3 is C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl, —OC 1 -C 6 alkyl, —OC 0 -C 3 alkylenecarbocyclyl, —OC 0 -C 3 alkyleneheterocyclyl; wherein any alkyl, carbocyclyl or heterocycylyl in R 1 , R 2 or R 3 are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, oxo, cyano, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl, —C(═O)NH 2 , Y—NRaRb, Y—O—Rb, Y—C(═O)Rb, Y—(C═O)NRaRb, Y—NRaC(═O)Rb, Y—NHSO p Rb, Y—S(═O) p Rb and Y—S(═O) p NRaRb, Y—C(═O)ORb, Y—NRaC(═O)ORb; Y is independently a bond or C 1 -C 3 alkylene; Ra is independently H, C 1 -C 6 alkyl or C 1 -C 6 alkoxy; Rb is independently H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 0 -C 3 alkylenecarbocyclyl or C 0 -C 3 alkyleneheterocyclyl; or Ra and Rb together with the nitrogen to which they are attached join to form a heterocyclyl group; p is independently 1 or 2; n is 3, 4, 5 or 6; ----- denotes an optional double bond; Rq is H or when L is CRz, Rq can also be C 1 -C 6 alkyl; Ry and Ry′ are independently C 1 -C 6 alkyl; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; W is —CH 2 —, —O—, —OC(═O)NH—, —OC(═O)—, —S—, —NH—, —NRa, —NHS(═O) 2 —, —NHC(═O)NH— or —NHC(═O)—, —NHC(═S)NH— or a bond; R 8 is a ring system containing 1 or 2 saturated, partially saturated or unsaturated rings each of which has 4-7 ring atoms and each of which has 0 to 4 hetero atoms independently selected from S, O and N, the ring system being optionally spaced from W by a C 1 -C 3 alkylene group; or R 8 is C 1 -C 6 alkyl; any of which R 8 groups can be optionally mono-, di-, or tri-substituted with R 9 , wherein R 9 is independently selected from the group consisting of halo, oxo, cyano, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl, —C(═O)NH 2 , Y—NRaRb, Y—O—Rb, Y—C(═O)Rb, Y—(C═O)NRaRb, Y—NRaC(═O)Rb, Y—NHS(═O) p Rb, Y—S(═O) p Rb, Y—S(═O) p NRaRb, Y—C(═O)ORb, Y—NRaC(O)ORb; wherein said carbocyclyl or heterocyclyl is optionally substituted with R 10 ; wherein R 10 is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, amino, amido, sulfonyl, (C 1 -C 3 alkyl)sulfonyl, nitro, hydroxy, mercapto, halo, haloalkyl, carboxyl.