Patent ID: 8632771

Claim:
An isolated vitamin K-dependent polypeptide linked to a polyethylene glycol (PEG) polymer, wherein said polypeptide is wild-type factor VIIa, wherein said PEG polymer has a molecular weight of 10,000 to 40,000 Da and is covalently linked to said wild-type factor VIIa polypeptide such that said wild-type factor VIIa polypeptide is monosubstituted with said PEG polymer, wherein said wild-type factor VIIa polypeptide linked to PEG retains measurable coagulation activity to a level that is from 4% to 15% of the level of coagulation activity of wild-type factor VIIa that is not conjugated to a PEG polymer, and where said coagulation activity is measured using a thromboplastin assay.