Patent ID: 7638648

Claim:
A compound of the formula wherein A is a phenyl or naphthyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl and heteroaryl groups being optionally substituted with one or two R 2 groups; X is NRR 7 where R is H, or alkyl of 1 to 6 carbons or benzyl; Y is H, or alkyl of 1 to 10 carbons, benzyl, C 1-6 alkyl or halogen substituted benzyl, fluoro-substituted alkyl of 1 to 10 carbons, cycloalkyl of 3 to 6 carbons, C 1-6 alkyl substituted cycloalkyl of 3 to 6 carbons, alkenyl of 2 to 6 carbons and having 1 or 2 double bonds, alkynyl of 2 to 6 carbons, alkenyl-alkynyl of 4 to 6 carbons, alkynyl-alkenyl of 4 to 6 carbons, CI, Br, I, or —COOR 1 ; Z is —≡C— R 1 is independently H or alkyl of 1 to 6 carbons; R 2 is independently H, alkyl of 1 to 6 carbons, F, Cl, Br, I, CF 3 , fluoro substituted alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons; R 3 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, alkylthio of 1 to 6 carbons or benzyl; m is an integer having the values 0 to 3; W is —CR 5 ═CR 5 —; R 5 is independently H, halogen, or alkyl of 1 to 3 carbons; R 7 is H, alkyl of 1 to 6 carbons, cycloalkyl of 3 to 6 carbons or C 1-6 alkyl substituted cycloalkyl of 1 to 6 carbons, and R 8 is H, alkyl of 1 to 6 carbons, —CH 2 O(C 1-6 -alkyl), CH 2 OCO(C 1-6 -alkyl) or a pharmaceutically acceptable salt thereof.