Patent ID: 8314155

Claim:
A method of treating excessive sleepiness in a subject in need thereof comprising administering to said subject a therapeutically effective amount of a compound of formula (IV): wherein Ar is wherein X is a bond, CH 2 , or O; ring A optionally substituted with one to three groups selected from F, Cl, Br, I, OR 21 , OR 25 , NR 23 R 24 , NHOH, NO 2 , CN, C 1 -C 6 alkyl, and C(═O)R 22 ; Y′ is C 1 -C 4 alkylene, wherein said alkylene group is optionally substituted with an R 20 group; R 12 and R 13 at each occurrence are each independently selected from H, and C 1 -C 6 alkyl, wherein said alkyl group can optionally be substituted with one or two CN, OR 21 , O(CH 2 ) 1-4 OR 21 , C(═O)N(R 21 ) 2 , or pyridyl groups, or R 12 and R 13 , together with the nitrogen to which they are attached, form a pyrrolidinyl, piperidinyl, or piperazinyl ring, optionally substituted with OR 21 , C(═O)N(R 21 ) 2 , or C(═O)R 21 ; R 20 at each occurrence is independently selected from F, Cl, Br, I, OR 21 , OR 25 , NR 23 R 24 , NHOH, NO 2 , CN, and CF 3 ; R 21 at each occurrence is independently selected from H and C 1 -C 6 alkyl; R 22 at each occurrence is independently selected from C 1 -C 6 alkyl, and phenyl; R 23 and R 24 at each occurrence are each independently selected from H and C 1 -C 6 alkyl, or R 23 and R 24 , together with the nitrogen to which they are attached, form a 5-6 membered heterocycloalkyl; R 25 at each occurrence is independently the residue of an amino acid after the hydroxyl group of the carboxyl group is removed; or a stereoisomeric form, mixture of stereoisomeric forms or pharmaceutically acceptable salt thereof.