Patent ID: 8202881

Claim:
A compound of the formula or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein X is C 1-4 alkyl; Y is C 1-4 alkyl; R is any of which are optionally fused with a 5 or 6 membered carbocycle or heterocycle, said heterocycle having one heteroatom selected from NR 3 or S, said fused carbocycle or heterocycle being optionally substituted with 0-3 R 1 ; R 1 is H, halo, CN, C 1-6 alkyl substituted with 0-3 R c , CF 3 , CONR a R a , NR a R a , COOR b , SO 2 —C 1-4 alkyl, C(O)R d , cycloalkyl substituted with 0-3 R e , furanyl, tetrahydropyranyl or pyridinyl; R 2 is H, C 1-6 alkyl substituted with 0-3 R c , C(O)O—C 1-4 alkyl, SO 2 —C 1-4 alkyl, cycloalkyl substituted with 0-3 R e , tetrahydropyranyl or R 2 is absent; R 3 is H, C(O)O—C 1-4 alkyl, or R 3 is absent; R a is H, C 1-6 alkyl substituted with 0-3 R e , C 3-6 cycloalkyl substituted with 0-3 R e , tetrahydropyranyl or dioxotetrahydrothiophenyl; R b is H or C 1-6 alkyl; R c is H, halo, CN, OH, O—C 1-4 alkyl, O—C 1-4 alkyl-O—C 1-4 alkyl, NH 2 , N(C 1-4 alkyl) 2 , C(O)N(C 1-4 alkyl) 2 , SO 2 —C 1-4 alkyl, or morpholinyl or piperazinyl either of which are optionally substituted with 0-1 C 1-4 alkyl; R d is C 1-6 alkyl, or azeridinyl, azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, dioxidothiomorpholinyl or tetrahydropyranyl, any of which are substituted with 0-2 R e ; and R e is H, halo, CN, C 1-4 alkyl, OH, O—C 1-4 alkyl, SO 2 —C 1-4 alkyl, NHC(O)—C 1-4 alkyl, morpholinyl, OC(O)—C 1-4 alkyl, C(O)N(C 1-4 alkyl) 2 , or O—C 1-4 alkyl-O—C 1-4 alkyl.