Patent ID: 7781477

Claim:
A method of treating a disease selected from the group consisting of bladder hyperactivity, bladder hyperreflexia, bladder instability, incontinence, urgent urination, urinary incontinence, cystitis, renal colic, pelvic hypersensitivity, pelvic pain, asthma and cough, comprising administering to a patient in need of said treatment a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: in which X 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 and Z 5 represent, independently of one another, a hydrogen or halogen atom or a C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 alkoxy, C 1 -C 6 fluoroalkoxy, cyano, C(O)NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 thioalkyl, —S(O)—(C 1 -C 6 ) alkyl, —S(O) 2 —(C 1 -C 6 )alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5 or aryl group; X 5 represents a hydrogen or halogen atom or a C 1 -C 6 alkyl or C 1 -C 6 fluoroalkyl group; R represents a 4-, 5-, 6- or 7-indolyl group, R optionally being substituted in the 1, 2 or 3 position by one or more groups chosen from the C 1 -C 6 alkyl and C 1 -C 6 fluoroalkyl groups; R optionally being substituted in the 4, 5, 6 or 7 position by one or more groups chosen from halogen atoms or C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 alkoxy or C 1 -C 6 fluoroalkoxy groups; Y represents a hydrogen atom or a C 1 -C 6 alkyl group; n is equal to 0, 1, 2 or 3; R 1 and R 2 represent, independently of one another, a hydrogen atom or a C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, (C 3 -C 7 )cycloalkyl(C 1 -C 3 )alkyl or aryl group; or R 1 and R 2 form, together with the nitrogen atom which carries them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine or homopiperazine group, said group optionally being substituted by a C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, (C 3 -C 7 )cycloalkyl(C 1 -C 3 )alkyl or aryl group; R 3 and R 4 represent, independently of one another, a hydrogen atom or a C 1 -C 6 alkyl or aryl group; and R 5 represents a C 1 -C 6 alkyl or aryl group.