Patent ID: 8603435

Claim:
A compound according to the chemical structure: (Y) q —X m -(ABC) n -Cycpeptide Wherein Y is a chelate group, said chelate group optionally incorporating or complexing with a radioisotope; Each X is independently an amino acid residue which may be optionally acylated at its amino terminal end or an amino acid linker according to the chemical structure: ABC is an amino acid linker wherein A is absent or is a neutral or negatively charged amino acid at physiological pH which is optionally acylated at its amino terminal end; B is a neutral or negatively charged amino acid at physiological pH which is optionally acylated at its amino terminal end; C is absent or is a neutral or negatively charged amino acid at physiological pH; m is an integer from 0 to 250; n is 0 or 1; p is an integer from 0 to 20; q is 0 or 1, and Cycpeptide is a cyclic peptide comprising between 11 and 13 amino acids according to the structure: c [Lys-(X)-Glu-His-(Y b )-Arg-Trp-(Z) j -Arg-Pro-W-T] Wherein X is norleucine (Nle), leucine or isoleucine; Y b is D-phenylalanine or L-phenylalanine; Z is glycine or alanine; W is valine, leucine or isoleucine; T is aspartic acid, glutamic acid or a Where Z r is an amino acid residue or an amino acid linker according to the chemical structure: j is 0, 1 or 2; r is an integer from 0 to 250; s is 1; w is 0 to 20; or a pharmaceutically acceptable salt thereof, optionally complexed with at least one radioisotope, selected from the group consisting of 86 Y, 90 Y, 111 In, 177 Lu, 225 Ac, 212 Bi, 213 Bi, 66 Ga, 67 Ga, 68 Ga, 64 Cu, 67 Cu, 71 As, 72 As, 76 As, 77 As, 65 Zn, 48 V, 203 Pb, 209 Pb, 212 Pb, 166 Ho, 149 Pm, 153 Sm, 201 Tl, 188 Re, 186 Re and 99m Tc.