Patent ID: 7514420

Claim:
A compound having the structure or a pharmaceutically acceptable salt of the compound wherein, A is —CR 9 R 10 —; E is —C(O)— or —CR 5 R 6 —; G is —CR 3 R 4 —; K is —CR 1 R 2 —; R and R′ independently are —F, —Cl, —Br, —I, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, —CN, —COOR 14 , —C(O)NR 14 R 15 , —NO 2 , —NR 14 R 15 , —NR 14 —C(O)—R 15 , —OH, substituted or unsubstituted lower alkoxy, or —S(O) 0-2 R 14 ; R 1 is —OR 11 ; wherein R 11 is —H, substituted or unsubstituted alkyl, substituted or unsubstituted alkene, substituted or unsubstituted alkyne, —C(O)—R 12 , —C(O)—NR 12 R 13 , —C(O)—OR 12 , —C(S)—R 12 , —NR 12 R 13 , —S(O) 2 —R 12 , —S(O) 2 —OR 12 , or —P(O)(OR 12 )(OR 13 ) 0-1 ; R 2 is —H, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene or substituted or unsubstituted lower alkyne; R 3 and R 5 independently are —H, —F, —CI, —Br, —I, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene or substituted or unsubstituted lower alkyne; R 4 and R 6 independently are —H, —COOR 14 , —C(O)NR 14 R 15 , —NO 2 , —NR 14 R 15 , —NR 14 —C(O)—R 15 , —OH or substituted or unsubstituted lower alkoxy; R 7 and R 8 independently are —H or substituted or unsubstituted lower alkyl; R 9 is —OH or substituted or unsubstituted lower alkoxy; R 10 is substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, substituted or unsubstituted —S(O) 0-2 (lower alkyl) or R 9 and R 10 , together with the carbon to which they are attached, form a 5-, 6-, or 7- member heterocyclyl or cycloalkyl group; R 12 and R 13 independently are —H, substituted or unsubstituted alkyl, substituted or unsubstituted alkene, or substituted or unsubstituted alkyne; R 14 and R 15 independently are —H, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, substituted or unsubstituted C 6-10 aryl, or substituted or unsubstituted C 7-12 arylalkyl; n is 0, 1, or 2; and n′ is 0, 1, or 2.