Patent ID: 8415379

Claim:
A compound of formula I, wherein R 1 is selected from the group consisting of v) pyridinyl, vi) pyridinyl substituted by 1-4 substituents individually selected from acetamidyl, acetyl, acetylamino, amido, amino, carboxy, cyano, halogen, halogen-lower alkoxy, halogen-lower alkyl, hydroxy, hydroxy-lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, lower alkyl, (lower alkyl,lower alkyl)N—, (lower alkyl,H)N—, nitro and lower alkyl-S(O) 2 —; R 2 is H, lower alkyl or lower alkyl substituted by 1-5 substituents individually selected from amino, halogen, halogen-lower alkoxy, hydroxy, lower alkoxy, (lower alkyl,lower alkyl)N—, (lower alkyl,H)N—, nitro and lower alkyl-S(O) 2 —; R 3 is H, lower alkyl or lower alkyl substituted by 1-5 substituents individually selected from amino, halogen, halogen-lower alkoxy, hydroxy, lower alkoxy, (lower alkyl,lower alkyl)N—, (lower alkyl,H)N—, nitro and lower alkyl-S(O) 2 —; R 4 is selected from the group consisting of i) H, ii) lower alkyl, iii) lower alkyl substituted by substituted by 1-5 substituents individually selected from amino, halogen, halogen-lower alkoxy, hydroxy, lower alkoxy, cycloalkyl, (lower alkyl,lower alkyl)N—, (lower alkyl,H)N—, nitro and lower alkyl-S(O) 2 —, vi) cycloalkyl, vii) cycloalkyl substituted by 1-4 substituents individually selected from acetamidyl, acetyl, acetylamino, amido, amino, carboxy, cyano, halogen, halogen-lower alkoxy, halogen-lower alkyl, hydroxy, hydroxy-lower alkyl, lower alkoxy, lower alkoxy-lower alkyl, lower alkyl, (lower alkyl,lower alkyl)N—, (lower alkyl,H)N—, nitro and lower alkyl-S(O) 2 —, ,and x) —NR 5 R 6 ; R 5 is H or lower alkyl; and R 6 is H or lower alkyl, or a pharmaceutically acceptable salt thereof.