Patent ID: 7662852

Claim:
A composition comprising as an active ingredient, at least a phorbol derivative of formula 1: wherein R 1 is a group of —(CH 2 ) a X(CH 2 ) b CH 3 wherein X is O or S, a is a number of 1 to 3, and b is a number of 0 to 5, or a group of —(CH 2 ) c X(CH 2 ) d YCH 3 wherein X and Y are O or S, c is a number of 1 to 3, and d is a number of 1 to 5, R 2 is a group of —CO(CH 2 ) n CH 3 wherein n is a number of 3 to 12, and R 3 , R 4 and R 5 are independently of one another, hydrogen atom, or an acetyl, benzyl, or tigloyl carboxylic acid residue, and having a specific safety index S.I.=CC 50 /EC 50 of 10 or more wherein EC 50 means a concentration at which HIV-1 induced cytopathogenic effect (CPE) in MT-4 cell is inhibited by 50%, and CC 50 means a concentration at which survival of MT-4 cell in a cell proliferation test is reduced by 50% and a pharmaceutically acceptable excipient.