Patent ID: 8188141

Claim:
An isolated compound having the structure: or pharmaceutically acceptable salt, amide, or ester thereof; wherein n is an integer from 1 to 4; R 1 and R 2 are each independently hydrogen, an aliphatic moiety, or an aromatic moiety; R 3 is hydrogen, halogen, aliphatic, heteroaliphatic, alicyclic, heterocyclic, aryl or heteroaryl moiety, or —WR 3A ; wherein W is independently —O—, —S—, —NR 3B — or —C(═O)—, wherein R 3A is hydrogen, an aliphatic, heteroaliphatic, alicyclic, heterocyclic, aryl or heteroaryl moiety; —C(═O)R 3C , —Si(R 3C ) 3 , —C(═S)R 3C , —C(═NR 3C )R 3C , —SO 2 R 3C , or —ZR 3C , wherein Z is —O—, —S—, —NR 3D , wherein each occurrence of R 3B , R 3C and R 3D is independently hydrogen, or an aliphatic, heteroaliphatic, alicyclic, heterocyclic, aryl or heteroaryl moiety; R 4 is halogen, —OR 4A , —OC(═O)R 4A or —NR 4A R 4B ; wherein R 4A and R 4B are independently hydrogen, an aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic or heteroaromatic moiety; a nitrogen protecting group or an oxygen protecting group; or R 4A and R 4B , taken together with the nitrogen atom to which they are attached, form a heterocyclic or heteroaryl moiety; or R 4 , taken together with the carbon atom to which it is attached forms a moiety having the structure: R 5 is hydrogen, an aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic or heteroaromatic moiety; R a is independently hydrogen, —CN, —S(O) 1-2 R a1 , —NO 2 , —COR a1 , —CO 2 R a1 , —NR a1 C(═O)R a2 , NR a1 C(═O)OR a2 , —CONR a1 R a2 , or an aliphatic moiety, wherein each occurrence of R a1 and R a2 is independently hydrogen, or an aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic or heteroaromatic moiety; R b is independently hydrogen, an aliphatic moiety, or an aromatic moiety; X 1 is O, or S; Q is hydrogen, halogen, —CN, C 1-6 aliphatic optionally substituted with halogen, C 1-6 heteroaliphatic, or —WR Q1 ; wherein W is independently —O—, —S— or —NR Q3 —, wherein each occurrence of R Q1 and R Q3 is independently hydrogen or C 1-6 alkyl; Y 1 and Y 2 are independently hydrogen, an aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic or heteroaromatic moiety; or —WR Y1 , wherein W is independently —O—, —S— or —NR Y2 —, and each occurrence of R Y1 and R Y2 is independently hydrogen, or an aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic or heteroaromatic moiety; or Y 1 and Y 2 together with the carbon atom to which they are attached form a moiety having the structure: