Patent ID: 7309716

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: r is 0; Z is N; Y is hydrogen; W is formula Ia: wherein: A is -T-NH—, wherein: T is —CH 2 CH 2 —; V is —C(O)—; Q is —CH 2 O—; m is 1; Ring E is phenyl; s is 0-1; R B is selected from J wherein: J is halo, CN, NO 2 , CF 3 , OCF 3 , OH, SR 6 , S(O)R 6 , SO 2 R 6 , NH 2 , NHR 6 , N(R 6 ) 2 , NR 6 R 8 , C(O)OH, C(O)OR 6 or OR 6 ; or two J on adjacent ring atoms, taken together, form 1,2-methylenedioxy or 1,2-ethylenedioxy; R 6 is hydrogen or a C 1-6 aliphatic group substituted with R 7 , wherein: R 7 is a C 3-8 cycloaliphatic, C 6-10 aryl, a 5-10 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 3-10 membered heterocyclyl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein R 7 is optionally substituted with up to two substituents independently selected from R, 1,2-metthylenedioxy, 1,2-ethylenedioxy, or (CH 2 ) n -G, wherein n is 0 or 1; and wherein G is selected from halo, CN, NO 2 , CF 3 , OCF 3 , OH, S-aliphatic, S(O)-aliphatic, SO 2 -aliphatic, NH 2 , N-aliphatic, N(aliphatic) 2 , N(aliphatic)R 8 , COOH, C(O)O(-aliphatic, or O-aliphatic; and R 8 is an amino protecting group.