Patent ID: 8741915

Claim:
The compound of Formula I or pharmaceutically acceptable salts thereof: wherein X is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl, each having 6 members or less in the ring; Y is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, C 4 -C 6 cycloalkyl, substituted C 4 -C 6 cycloalkyl, heterocyclyl, and substituted heterocyclyl; Z is selected from the group consisting of O, S and NR 7 ; R 1 , R 2 and R 7 are independently selected from the group consisting of hydrogen, and C 1 -C 6 alkyl; R 3 is selected from the group consisting of hydrogen, nitro, cyano, carboxy, carbamoyl, methylsulfonamido, fluoro, chloro, bromo, hydroxy, methylsulfonyl, and methylsulfinyl, isoxazol-4-yl, C 1 -C 6 alkoxy, —C(NH)NHOH, sulfonic acid, and acetyl; R 4 is selected from the group consisting of hydroxy, carboxy, and tetrazol-5-yl; R 5 is selected from the group consisting of hydrogen, hydroxy, carboxy, chloro, fluoro, cyano, —O(CH 2 ) 1-6 NMe 2 , C 1 -C 6 alkyl, —O(CH 2 ) 1-6 OCH 3 , —O(CH 2 ) 1-6 OH, acetyl, CF 3 , and C 1 -C 6 alkoxy; and R 6 is selected from the group consisting of hydrogen and hydroxy.