Patent ID: 7172769

Claim:
A pharmaceutical composition, wherein: the composition comprises one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility in a therapeutically effective amount, wherein the drug is present in solid particles having a weight average particle size of about 500 nm to about 900 nm; the selective cyclooxygenase-2 inhibitory drug is a compound of formula: R 3 methyl or amino; R 4 is hydrogen, C 1-4 alkyl, or C 1-4 alkoxy; X is N or CR 5 ; R 5 is hydrogen or halogen; and Y and Z are independently carbon or nitrogen atoms defining adjacent atoms of a five- to six-membered ring that is unsubstituted or substituted at one or more positions with oxo, halo, methyl, or halomethyl.