Patent ID: 7244722

Claim:
A compound of the general formula (I): wherein m is 1 or 2; n is 0, 1, 2, 3 or 4; R 1 is H, C 1-6 -alkyl, aryl-C 1 -C 3 -alkyl, heteroaryl-C 1 -C 3 -alkyl, 2-hydroxyethyl, methoxy-C 2 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl, aryloxy-C 2 -C 3 -alkyl, or heteroaryloxy-C 2 -C 3 -alkyl; wherein any aryl or heteroaryl residue may be substituted with C 1-4 -alkyl, C 1-4 -alkoxy, C 1-4 -alkylthio, halogen, trifluoromethyl, trifluoromethoxy or cyano; R 2 and R 3 each, independently, represent H or CH 3 ; R 4 and R 5 each, independently, represent H, halogen, methyl, or together with the ring, to which carbon atoms they are attached, form a 1H-quinoxalin-2-one nucleus; and R 6 represents aryloxy, heteroaryloxy, arylthio, heteroarylthio, aryl-NH, heteroaryl-NH, aryl, arylcarbonyl, heteroaryl, or heteroarylcarbonyl; wherein any aryl or heteroaryl residue, alone or as part of another group, may be unsubstituted or substituted with one, two, three, four or five substituents, independently selected from aryl, aryl-C 1-2 -alkyl, arylcarbonyl, heteroaryl, heteroaryl-C 1-2 -alkyl, heteroarylcarbonyl, aryloxy, heteroaryloxy, arylthio, heteroarylthio, arylamino, heteroarylamino, C 3-6 -cycloalkyl, C 3-6 -cycloalkyloxy, C 3-6 -cycloalkylcarbonyl, C 1-6 -alkyl, C 2-6 -alkanoyl, C 2-6 -alkynyl, C 2-6 -alkenyl, or fluoro-C 2-4 -alkyloxy, halogen, trifluoromethyl, nitro, cyano, trifluoromethoxy, trifluoromethylthio, C 1-6 -alkoxy, C 1-6 -alkylthio, C 1-6 -alkylamino, C 1-4 -dialkylamino, hydroxy or oxo; wherein any aryl or heteroaryl residue as substituents on aryl or heteroaryl, alone or as part of another group, in turn may be substituted in one or more positions, independently of each other, by C 1-4 -alkyl, C 1-4 -alkoxy, C 1-4 -alkylthio, halogen, trifluoromethyl, trifluoromethoxy or cyano; and pharmaceutically acceptable salts, hydrates, geometrical isomers, tautomers, optical isomers, or N-oxides thereof, with the provisos that: R 2 and R 3 are not both CH 3 ; when n=1 and R 1 , R 2 , R 4 and R 5 are H and R 3 is H or CH 3 , then R 6 is not 3-pyridyloxy, 6-methyl-2-nitro-3-pyridyloxy, or 2-chloro-3-pyridyloxy; when n=0, then R 6 is not aryloxy, heteroaryloxy, arylthio, heteroarylthio, aryl-NH or heteroaryl-NH; and the compound of formula (I) is not 1-benzyl-3-(4-methyl-piperazin-1-yl)-1H-quinoxalin-2-one.