Patent ID: 7507728

Claim:
A compound comprising a halogen substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine of formula I wherein R 1 is hydrogen, halogen, lower alkyl, Si(CH 3 ) 3 , lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, lower alkenyl, lower alkenyloxy, ON, bicyclo[2.2.1]hept-5-en-2-yl, aryl which is optionally substituted by lower alkyl, amino or lower alkoxy, or is aryloxy, heteroaryl, benzo[1,3]dioxolyl, cycloalkyl, heterocycloalkyl, —O(CH 2 ) m OH, —CO(O)-lower alkyl, —N(R′) 2 or —C≡C—R″; R′ is hydrogen, lower alkyl, cycloalkyl, —C(O)-lower alkyl, —C(O)-cycloalkyl, —S(O) 2 -lower alkyl, or aryl which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen and lower alkyl substituted by halogen; R″ is hydrogen, —Si(CH 3 ) 3 , lower alkyl, cycloalkyl or —(CH 2 ) m —O-lower alkyl; R 2 is hydrogen, methyl or aryl; R 3 is halogen; R 4 is hydrogen or halogen; n is 1 or 2; and m is 1, 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.