Patent ID: 7084126

Claim:
A method of protecting a mAChR receptor in an Alzheimer's subject in need thereof from oxidative stress, comprising administering at least one pyrophosphate analog comprising the structure: where each X is independently O, CH 2 , NH, or S; R 1 is H, a CH 3 , guanyl, adenylyl, glycerol, acyl glycerol, diacyl glycerol, serine, threonine, tyrosine, arachidonyl, —PO(OH)(OR 2 ), or —(PO(OH)O) m —PO(OH)(OR 2 ) and m is 1–3; R 2 is H, CH 3 , guanyl, adenylyl, glycerol, acyl glycerol, diacyl glycerol, serine, threonine, tyrosine, or arachidonyl; and n is 1–6; or the structure: where n′=2–4; X′ is 0; RCR 1 ; CR; C (n′=4), CH (n′=3), or CH 2 (n′=2); NH; N; S; and R and/or R 1 is H, OH, CH 3 , or (CH 2 ) m NH 2 where m=1–6; or a dinucleoside-5–5′-pyrophosphate, a cyclopyrophosphate of purine, a pyrimidine acyclonucleoside; or a pharmaceutically acceptable salt thereof.