Patent ID: 8168788

Claim:
A compound of formula II-A: or a pharmaceutically acceptable salt thereof, wherein: a) R 1 is —OR 4 or —OCO(C 1 -C 6 alkyl); ring A is substituted with q occurrences of R A ; q is 0, 1, or 2; each occurrence of R A is independently halogen, linear or branched C 1 -C 6 alkyl, or C 3 -C 6 cycloalkyl ring; each occurrence of R 4 is independently hydrogen; b) ring B is substituted with r occurrences of —R B ; r is 0, 1, or 2; each occurrence of —R B is independently C 1 -C 3 alkyl; c) R 2 is —Cy 2 , or -T-Cy 2 ; X is N; T, when present, is —CO—, or —CH 2 —; Cy 2 is phenyl or naphthyl; wherein Cy 2 is substituted with 0, 1, or 2 occurrences of —R 6a ; each occurrence of —R 6a is independently —Cl, —Br, —F, —CN, —OCH 3 , —OCH 2 CH 3 , —OCH 2 CH 2 CH 3 , —CF 3 , —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , —CH(CH 3 ) 2 , —C(CH 3 ) 3 , —COOH, —COOCH 3 , or —COOCH 2 CH 3 ; d) Cy 1 is phenyl or naphthyl; wherein Cy 1 is substituted with 0, 1, or 2 occurrences of —R 10a ; each occurrence of —R 10a is independently —Cl, —Br, —F, —NO 2 , —CN, —OCH 3 , —OCH 2 CH 3 , —OCH 2 CH 2 CH 3 , —CF 3 , —OCF 3 , —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , —C(CH 3 ) 3 , —CH(CH 3 ) 2 , t-Bu, —NHCOCH 3 , —NHCONHCH 3 , —SCH 3 , —SCH 2 CH 3 , —SCH 2 CH 2 CH 3 , —NH 2 , —NHCH 3 , —SO 2 NH 2 , —COOH, —COOCH 3 , —COOCH 2 CH 3 , —NHCH 3 , —N(CH 3 ) 2 , —NH(CH 2 CH 3 ), —N(CH 2 CH 3 ) 2 , —OC(CH 3 ) 2 CO 2 H, —OCH 2 CO 2 H, —C(CH 3 ) 2 OH, —CONH 2 , —NHCONH 2 , —NHCON(CH 3 ) 2 , or —NHCOOCH 3 ; and 0 or 1 occurrence of —R 10b , J-R 10b , or W-J-R 10b , and —R 10b , J-R 10b , or W-J-R is morpholinyl, tetrazolyl, phenyl, benzyl, —NHCO(phenyl), —NHCO(benzyl), —NH(phenyl), —NHCH 2 (phenyl), —NH(benzyl), —S(phenyl), —S(benzyl), —O(phenyl), or —O(benzyl), wherein the phenyl and benzyl groups are optionally substituted.