Patent ID: 8853667

Claim:
A bio sensor device comprising: a field-effect transistor (FET) structure having a source, a drain, a gate region and a semiconductor substrate, wherein the semiconductor substrate includes a transport channel between the source and the drain and wherein the transport channel is configured to be controlled via a voltage applied to the gate region, and wherein the gate region includes a multilayer structure having: a first layer located adjacent to the transport channel, wherein the first layer is at least one of an insulator, a wide energy gap lattice matched semiconductor and a pseudomorphic semiconductor layer, wherein the multilayer structure includes at least one layer of cladded quantum dots having an outer cladding layer, wherein the at least one layer of cladded quantum dots is constructed from the group comprised of SiO x -cladded Si nanocrystal quantum dots and GeO x -cladded Ge nanocrystal quantum dots, wherein the outer cladding layer is functionalized with a chemical group, wherein the chemical group is bonded to recognition elements selected from a group comprising DNA, RNA, miRNA and antibodies, and wherein the recognition elements are bonded with target biomarkers including at least one of proteins, enzymes, and analytes; and a top gate electrode fixed above the outer cladding layer to be in contact with a solution containing at least one target molecule.