Patent ID: 8394947

Claim:
A composition comprising a first oligomeric compound and a second oligomeric compound, wherein: the first oligomeric compound is capable of hybridizing with at least a portion of the second oligomeric compound and to a selected target nucleic acid; each of the first and the second oligomeric compounds independently comprises a contiguous sequence of from about 19 to about 23 nucleosides linked by internucleoside linking groups; each of the first and the second oligomeric compounds optionally comprises a phosphate group, a 3′ or 5′-overhang or a conjugate group; and the first oligomeric compound having a plurality of modified ribofuranosyl nucleosides at defined positions, and the modified ribofuranosyl nucleosides consisting of 2′-OCH 3 modified nucleosides at positions 6, 7, 10, 11, 17, 18 and 19 of the first oligomeric compound counting from the terminal 5′-hybridizing nucleoside.