Patent ID: 7598286

Claim:
A compound of the formula I or II: an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein: A is (C═O), CHOH, C(OH)R, or CR′R″; R, R′, and R″ are each, independently, H, alkyl, aralkyl, or aryl; R 1 is cycloalkyl, cycloalkenyl, or aryl; R 2 , R 3 , R 5 , and R 6 are each, independently, hydrogen, hydroxy, lower alkyl, alkoxy, or halogen; R 4 , R 8 , R 9 , and R 10 are each, independently, hydrogen, lower alkyl, hydroxy, alkoxy, aralkoxy, halogen, CF 3 , aryl, aralkyl, heteroaryl or COOR 11 ; R 7 is hydrogen, alkyl, —(C═O)R 16 , —S(O) 2 R 17 , —S(O) 2 N(R 18 )(R 19 ), or D-glucuronidate; R 11 is hydrogen, lower alkyl, aryl, or aralkyl; R 16 is alkyl, aralkyl or aryl; R 17 is alkyl, aryl, heteroaryl, cycloalkyl, alkenyl, cycloalkenyl, or alkynyl; and R 18 and R 19 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, monofluoroalkyl, perfluoroalkyl, aryl, arylalkyl, cycloalkenyl, heteroaryl, heteroarylalkyl, hydroxy-(C 2 -C 6 )alkyl, alkoxyalkyl, alkylthioalkyl, carbonyl, acyl, alkoxycarbonyl, —C(O)NH 2 , alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminoalkyl, or dialkylaminoalkyl; or R 18 and R 19 are taken together with the nitrogen atom to which they are attached to form a saturated, unsaturated or partially saturated C 4 -C 6 carbon ring.