Patent ID: 7459465

Claim:
An isoquinoline compound represented by the following formula (I): R 1 is a hydrogen atom, a halogen atom, alkyl, alkoxy, haloalkyl, a hydroxyl group, amino, dialkylamino, nitro, cyano, acyl, carboxyl, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, acylamino, diacylamino, thiol, alkylthio, alkoxycarbonylamino, sulfamoyl, N-alkylsulfamoyl, N,N-dialkylsulfamoyl or alkoxyalkyloxy; Y is absent or an alkylene chain having 1 to 8 carbon atoms wherein an optional carbon atom may have a hydroxyl group; and R is represented by the following formula (II): X is CH or a nitrogen atom, provided that when Y is absent in the formula (I), then X should be CH; W is CH or a nitrogen atom, provided that when X is CH, then W should be a nitrogen atom; s is an integer of 1 to 5; t is an integer of 1 to 5; when R 3 is a hydrogen atom, alkyl, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, alkylsulfonyl, acyl, acylamino optionally having a substituent, benzoylamino optionally having a substituent, arylalkyl, sulfamoyl or alkylsulfonylamino, R 2 is a hydrogen atom, alkyl, a hydroxyl group or hydroxyalkyl and R 2′ is a hydroxyl group, hydroxyalkyl or alkoxyalkyl; and when R 3 is hydroxyalkyl, R 2 and R 2′ are the same or different and each is a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl, alkoxycarbonyl, dialkylaminoalkyl or dialkylcarbamoyl, or R 2 and R 2′ are taken together to form ketone, an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof.