Patent ID: 8030033

Claim:
A method for determining the prognosis of a clinical response in a human patient to a central nervous system (CNS)-active medicament which is a substrate of the ABCB1 protein comprising the step of performing a genotyping analysis of a biological sample from the patient to determine the presence of at least one polymorphism in the ABCB1 gene of said patient wherein said polymorphism is selected from the group consisting of rs 2235015, rs 2235040, is 2235067, rs 2032583, is 17064, rs2032588, is 1055302, and combinations thereof as well as polymorphisms that are in linkage disequilibrium with said at least one polymorphism, where the presence of said polymorphism is associated with remission to said CNS-active medicament which is a substrate of the ABCB1 protein, and determining a prognosis for said patient based on said genotyping analysis.