Patent ID: 7365078

Claim:
A triaza-cyclopenta[cd]indene derivative represented by the following formula [I]: (wherein R 1 and R 2 are the same or different, and independently are hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, hydroxy-C 1-6 alkyl, cyano-C 1-6 alkyl, carbamoyl-C 1-6 alkyl or di(C 1-6 alkyl)amino-C 1-6 alkyl, cyano, carbamoyl or aryl; R 3 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-6 alkyl, halogen, C 1-6 alkoxy, C 3-7 cycloalkyloxy, C 1-6 alkylthio or —N(R 6 )R 7 ; R 4 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl or C 3-7 cycloalkyl-C 1-6 alkyl; R 5 is hydrogen, C 1-6 alkyl, aryl-C 1-6 alkyl or carbamoyl; Ar is aryl or heteroaryl which aryl or heteroaryl is unsubstituted or substituted with 1 or more substituents, which are the same or different, selected from the group consisting of halogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, cyano, nitro, hydroxy, —CO 2 R 8 , —C(═O)R 9 , —CONR 10 R 11 , —OC(═O)R 12 , —NR 13 CO 2 R 14 , —S(═O) r NR 15 R 16 , trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoromethoxy and —N(R 17 )R 18 ; R 8 and R 14 are the same or different, and independently are hydrogen or C 1-5 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-5 alkyl, aryl or aryl-C 1-5 alkyl; R 6 , R 7 , R 9 , R 10 , R 11 , R 12 , R 13 , R 15 , R 16 , R 17 , and R 18 are the same or different, and independently are hydrogen, C 1-6 alkyl or C 3-7 cycloalkyl; r is 1 or 2; or individual isomers thereof or racemic or non-racemic mixtures of isomers thereof, or pharmaceutically acceptable salts and hydrates thereof.