Patent ID: 7678766

Claim:
A method for preventing or treating a retrovirus infection, comprising administering to a mammal in need or desire thereof an effective amount of a cyclosporin derivative substituted at the 3-position having the formula: in which: 1) the radicals R 1 , R 2 , and R 4 to R 11 , and Z 1 , Z 2 , and Z 4 to Z 11 are defined as for cyclosporin A and R 3 is a radical —S-Alk-R o in which: Alk is an alkylene radical comprising from 2 to 6 straight- or branched-chain carbon atoms or a cycloalkylene radical comprising from 3 to 6 carbon atoms; and R o is a carboxyl or alkyloxycarbonyl radical; or an —NG 1 G 2 radical in which G 1 and G 2 , which are identical or different, are each a hydrogen atom; or a phenyl, cycloalkyl (C 3-6 ), alkenyl (C 2-4 ), or alkyl radical, each of which is optionally substituted by a halogen atom, an alkyloxy, alkyloxycarbonyl, amino, alkylamino, or dialkylamino radical; or a benzyl radical or a saturated or unsaturated heterocyclyl radical comprising 5 or 6 ring members and from 1 to 3 heteroatoms; or G 1 and G 2 form, with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising from 4 to 6 ring members which can comprise another heteroatom chosen from nitrogen, oxygen, and sulphur and which is optionally substituted by alkyl, phenyl, or benzyl; or a radical of formula: in which G 1 and G 2 are defined as above, G 3 is a hydrogen atom or an alkyl radical, and n is an integer from 2 to 4, the alkyl portions or radicals defined above are straight or branched and comprise from 1 to 4 carbon atoms; or one or more hydroxyl groups and optionally one or more non-methylated nitrogen atoms at the α position and optionally any other deprotonatable acidic group present in said formula (IV) are optionally deprotonated or in the protected form.