Patent ID: 7495127

Claim:
A method of treatment of hypertension including essential hypertension, tonic bladder, disturbances of peripheral circulation, airway hyper-responsiveness, sensory neuron hypersensitivity, central spasm, or ischemic central nervous system disorder, which comprises administering an effective amount of a compound represented by the formula [I]: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently a hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde or nitrile; or R 4 and R 5 are bonded to each other to form a ring; or R 6 and R 7 are bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof, to a mammal in need thereof.