Patent ID: 7994189

Claim:
A dihydropyridine derivative compound according to Formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or phenyl, (1-5C)heteroaryl, both optionally substituted with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (1-4C)(di)alkylamino; R 2 , R 3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2-4C)alkenyloxy, (3-4C)alkynyloxy, halogen; R 4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1-4C)alkyl or (6-10C)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl, (1-9C)heteroaryl(1-4C)alkyl, the aryl or heteroaryl group optionally substituted with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (1-4C)(di)alkylamino, and if R 4 is phenyl, phenyl may, in addition, optionally be substituted with the substituents provided for under “aryl” and/or one or more substituents selected from (1-4C)alkylthio, (1-4C)alkylsulfonyl, R 5 -oxycarbonyl, R 5 -carbonyl or R 5 ,R 6 -aminocarbonyl; X is SO 2 , CH 2 , C(O) or X is absent, wherein if X is CH 2 , R 4 may furthermore be R 5 -oxycarbonyl or R 5 -carbonyl; R 5 , R 6 is independently H, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, (1-4C)alkoxycarbonyl(1-4C)alkyl, (1-4C)(di)alkylaminocarbonyl(1-4C)alkyl or (6-10C)arylaminocarbonyl(1-4C)alkyl, (1-9C)heteroarylaminocarbonyl(1-4C)alkyl, (6-10C)aryl, (1-9C)heteroaryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl(1-4C)alkyl, the aryl or heteroaryl group optionally substituted with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (1-4C)(di)alkylamino or R 5 , R 6 in R 5 , R 6 -aminocarbonyl may be joined in a (2-6C)heterocycloalkyl ring; wherein (1-9C)heteroaryl is selected from the group consisting of tetrazolyl, imidazolyl, thiadiazolyl, pyridinyl, (benzo)thienyl, (benzo)furyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, coumarinyl, quinoxalinyl and indolyl; with the proviso that the compound is not 2-methyl-5-oxo-7-phenyl-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile.