Patent ID: 7879594

Claim:
A method for detecting a target biomolecule in a sample comprising a plurality of biomolecules, whereby the target biomolecule is provided directly or indirectly with a tag, which is linked to a signal generating agent comprising a catalytic active moiety which catalyses the transformation of an additional soluble species to an insoluble precipitate, said method comprising the steps of: a) providing a solid support with a plurality of spatially different locations arranged on its surface, whereby at least one location is electrically conducting and a plurality of individual flexible nanoelectrodes with probe biomolecule attached thereto being linked to said location, b) bringing the sample in contact with the solid support comprising said probe biomolecules, thereby the probe biomolecule and the target biomolecule interacting together, c) adding the soluble species, d) transforming the soluble species into the insoluble precipitate forming a deposit essentially on or at the nanoelectrodes, thereby decreasing the flexibility of the nanoelectrodes e) measuring the electrical conductivity of the plurality of the nanoelectrodes at least one location, wherein a decrease in the flexibility of the electrode causes a decrease in the electrical conductivity to indicate the presence of the target biomolecule.