Patent ID: 8895055

Claim:
A nanodisc without a membrane scaffold protein, the nanodisc comprising: a telodendrimer of formula I: (PEG) m -(A) p -L-D-(R) n (I) wherein D is a dendritic polymer having a single focal point group, a plurality of branched monomer units and a plurality of end groups, L is a bond or a linker linked to the focal point group of the dendritic polymer, each PEG is a polyethyleneglycol (PEG) polymer, wherein each PEG polymer has a molecular weight of 1-100 kDa, each R is independently selected from the group consisting of the end group of the dendritic polymer, a hydrophobic group, a hydrophilic group, an amphiphilic compound and a drug, such that when R is not an end group each R is linked to one of the end groups, subscript n is an integer from 2 to 20, wherein subscript n is equal to the number of end groups on the dendritic polymer, and wherein at least half the number n of R groups are each independently selected from the group consisting of a hydrophobic group, a hydrophilic group, an amphiphilic compound and a drug, subscript m is from 0 to 20, subscript p is 0 or 1, and radical A is a monomer or oligomer linked to at least two PEG groups; and a lipid, wherein the nanodisc does not include a membrane scaffold protein.