Patent ID: 7589208

Claim:
A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) wherein n is an integer of 1, 2 or 3; A n+ is a mono- or multivalent metal cation selected from Li + , Na + , K + , Mg 2+ , Ca 2+ , Mn 2+ , Cu 2+ , Zn 2+ , Al 3+ and Fe 3+ ; R is a straight or branched C 1 -C 4 -alkyl or -alkenyl or a cyclic C 3 -C 4 -alkyl; R5 is a straight or branched, saturated or unsaturated C 1 -C 4 -alkyl or -alkenyl, a cyclic C 3 -C 4 -alkyl, a straight or branched C 1 -C 4 -alkylthio, a cyclic C 3 -C 4 -alkylthio, a straight or branched C 1 -C 4 -alkylsulfinyl, a cyclic C 3 -C 4 -alkylsulfinyl, fluoro, chloro, bromo, trifluoromethyl or trifluoromethoxy; and R6 is hydrogen; or R5 and R6 taken together are methylenedioxy; R′ is hydrogen, a straight or branched, saturated or unsaturated C 1 -C 4 -alkyl or -alkenyl, a cyclic C 3 -C 4 -alkyl, a straight or branched C 1 -C 4 -alkoxy, a cyclic C 3 -C 4 -alkoxy, fluoro, chloro, bromo or trifluoromethyl; and R″ is hydrogen, fluoro or chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; an alkaline-reacting component, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; wherein said salt of formula (II) is essentially stable during storage at room temperature for a period of at least 3 years.