Patent ID: 7244436

Claim:
A method for treating pain in a patient, the method comprising the step of administering to the patient in need thereof a therapeutically effective amount of an agent to reduce the pain, the agent comprising a modified Clostridial toxin; wherein the modified Clostridial toxin comprises a Clostridial toxin light chain or light chain fragment thereof that cleaves a neurosecretory protein; a Clostridial toxin H N domain or fragment thereof that translocates a Clostridial toxin light chain or light chain fragment thereof across an endosome membrane and an orphanin polypeptide as a targeting moiety that binds to an orphanin receptor; and wherein the H C domain of the modified Clostridial toxin is removed or modified in order to reduce the binding of the modified Clostridial toxin to Clostridial toxin receptors at the neuromuscular junction.