Patent ID: 8071654

Claim:
A method for selectively inhibiting thromboxane formation in a mammal comprising administering to the mammal an effective amount of a hepoxilin analog of the formula: wherein X is CH 2 ; R 1 is â€”CH 2 CHâ•CHâ€”(CH 2 ) 3 â€”CORâ€³ wherein Râ€³ is OH, or Oâ€” lower alkyl; R 2 is OH, and R 3 is â€”CH 2 â€”CHâ•CHâ€”(CH 2 ) 4 â€”Râ€²â€³ wherein Râ€²â€³ is CH 2 OH, CH 2 â€”Oâ€” lower alkyl or CH 3 , or wherein X, R 2 and R 3 are as defined for formula I and R 4 is â€”CHâ•CHâ€”CH 2 â€”CHâ•CHâ€”(CH 2 ) 3 â€”CORâ€³ wherein Râ€³â•OH or Oâ€” lower alkyl, or of a sugar amide or sugar ester thereof; wherein said analog is administered in a concentration that inhibits thromboxane formation in the absence of inhibition of phospholipase A 2 .