Patent ID: 8586088

Claim:
An oral dosage form comprising: (i) an opioid agonist and (ii) multiparticulates comprising an opioid antagonist in a substantially non-releasable form, which, when administered intact, release at least 0.025 mg, but less than 0.25 mg, of the opioid antagonist at 1 hour, and, when administered after tampering, release 0.25 mg or more of the opioid antagonist at 1 hour, based on an in-vitro dissolution in 900 ml of Simulated Gastric Fluid using a USP Type II (paddle) apparatus at 75 rpm at 37° C., wherein the opioid antagonist is naltrexone or a pharmaceutically acceptable salt thereof, and the opioid agonist is coated on the surface of the multiparticulates, or the multiparticulates and the opioid agonist are included in the dosage form as separate pellets.