Patent ID: 8058446

Claim:
A compound of Formula 1: or pharmaceutically acceptable salts or mixtures thereof, wherein R is 4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl; mono-, di-, or tri-substituted 4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl wherein the substituents are independently chosen from hydroxyl, lower alkyl, sulfonyl, halo or lower alkoxy; 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl; mono-, di-, or tri-substituted 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl wherein the substituents are independently chosen from lower alkyl; R 4 is hydrogen, optionally fluoro-substituted lower alkyl, optionally fluoro-substituted lower alkoxy, cyano, halo, or hydroxy; R 21 and R 22 are independently hydrogen or lower alkyl; R 16 is chosen from hydrogen, cyano, cycloalkyl, lower alkyl or lower alkyl substituted by lower alkoxy or amino; L is C 0 -C 4 alkylene, â€”Oâ€”C 0 -C 4 alkylene, â€”(C 0 -C 4 alkylene)(SO)â€”, â€”(C 0 -C 4 alkylene)(SO 2 )â€”; or â€”(C 0 -C 4 alkylene)(Câ•O)â€”; and G is hydrogen, halo, hydroxy, alkoxy, nitro, alkyl, amino, carbamimidoyl, cycloalkyl, 5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl, lower alkoxy, 1H-tetrazol-5-yl, N-methylethanolamino, morpholin-4-yl, piperazin-1-yl, piperidin-1-yl, homopiperazin-1-yl, 4-acyl-piperazin-1-yl, 4-lower alkyl-piperazin-1-yl, 4-lower alkyl-piperidin-1-yl, 4-hydroxy-4-lower alkyl-piperidin-1-yl, 3-oxo-piperazin-1-yl, omopiperazin-1-yl, 4-lower alkyl-homopiperazin-1-yl, 4-lower alkyl-piperazin-1-yl wherein said alkyl is substituted with one or more substituents chosen from CN, lower alkoxy, halo, or SO 2 -lower alkyl, 4-lower alkoxy-piperidin-1-yl, 4-CN-piperidin-1-yl, 4-cyclopropyl-piperazin-1-yl, 4-(4-methylpiperazin-1-yl)-piperidin-1-yl, 4-morpholinopiperidin-1-yl, oxazepan-4-yl, 1,1-dioxo-thiomorpholin-4-yl, or â€”NR 7 R 8 wherein R 7 and R 8 are independently hydrogen or (C 1 -C 6 )alkyl, or wherein R 7 and R 8 , together with the nitrogen to which they are bound, form a 5- to 7-membered nitrogen containing ring which optionally further includes one or two additional N, O, or S atoms.