Patent ID: 8148321

Claim:
A novel therapeutic and diagnostic bioconjugate useful for target delivery of a compound, wherein said bioconjugate comprising: a. a substrate comprising LPXTG (SEQ ID NO: 11) peptide motif capable of recognizing sortase, wherein said substrate is selected from a group consisting of peptides, polypeptides, proteins, glycoprotein, lipoprotein, antibodies, radionucleotides, fluorophores, ligand chromophore and any compound comprising the LPXTG (SEQ ID NO: 11) peptide motif; and b. a biomolecule that is an aminoglycoside having a 6-Deoxy-6-amino-hexose moiety, wherein the glycine moiety of the LPXTG (SEQ ID NO: 11) motif is cleaved and the substrate is attached to the biomolecule via an amide bond between the resulting terminal threonyl carboxylate and the biomolecule to form the bioconjugate.