Patent ID: 7700616

Claim:
An amyloid binding compound of the formula wherein R 1 is NO 2 , R 2 is H, F, Cl, Br, I, NO 2 , CN, CF 3 , alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine, dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR 6 , NR 5 R 6 or R 6 , R 3 is H, F, Cl, Br, I, NO 2 , CN, CF 3 , alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine,dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR 6 , NR 5 R 6 or R 6 , R 4 is H, F, Cl, Br, I, NO 2 , CN, CF 3 , alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine, dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR 6 , NR 5 R 6 or R 6 , R 5 is C n H 2n+1 or —CH 2 —CH═CH—I and R 6 is C n H 2n+1 , —[CH 2 —CH 2 —O] m —R 5 , where n and m are independently 0, 1, 2, 3, 4, 5, 6 or 7, A is N or C, D is N or C, E is CH or N, Y is CH, Z is CH, B is O, N or CH and a, b, c, d, e and f each independently represent an optional bond, provided that when A and E are N, then B is CH, D is C and b and d are each a bond, or provided that when B, D and E are N, then A is C, b and e are each a bond, or provided that when E is N and B is O, then A and D are C, a and c are each a bond, or further provided that when D is C, then f is a bond or when D is N, then f is not a bond.