Patent ID: 7816365

Claim:
A compound of formula I in which X denotes C, B denotes N, CH or C—CN, R 1 denotes, A, —(CH 2 ) m —Ar or —(CH 2 ) m -Het 2 , R 2 denotes CN, R 3 denotes H, A, —S-A, —(CH 2 ) p —Ar, —(CH 2 ) p -Het, NH—(CH 2 ) p —Ar, NH—(CH 2 ) p -Het, NH 2 , NHA, NA 2 , NH-alkylene-NH 2 , NH-alkylene-NHA, NH-alkylene-NA 2 or NA-alkylene-NA 2 , R 4 denotes —(CH 2 ) s —(Ar 1 ) n —Y—R 6 , R 5 denotes H or CH 3 , or R 4 and R 5 together denote R 6 denotes Het 4 , —(CH 2 ) r —NH 2 , —(CH 2 ) r —NHA or —(CH 2 ) r —NA 2 , Y denotes O, S, (CH 2 ) q or NH, Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OH, OA, NH 2 , NO 2 , CN, COOH, COOA, CONH 2 , NHCOA, NHCONH 2 , NHSO 2 A, CHO, COA, SO 2 NH 2 , SO 2 A, —CH 2 —COOH or—OCH 2 —COOH, Ar 1 denotes phenylene or piperazinediyl, Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by Hal, A, NHA, NA 2 , OA, COOA, CN, —(CH 2 ) p —Ar, —(CH 2 ) t —OH, —(CH 2 ) p -Het 1 or carbonyl oxygen (═O), Het 1 denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono- or disubstituted by A or carbonyl oxygen (═O), Het 2 denotes a monocyclic aromatic heterocycle having 1 to 3 N, O and/or S atoms, which may be unsubstituted or mono- or disubstituted by A, Het 3 denotes a monocyclic saturated or aromatic heterocycle having 1 to 3 N, O and/or S atoms, which may be unsubstituted or mono- or disubstituted by A, Het 4 denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by Hal, A, CONH 2 , CONHA, CONA 2 or Ar 2 , Ar 2 denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OH, OA, NH 2 , NO 2 , CN, COOH, COOA, CONH 2 , NHCOA, NHCONH 2 , NHSO 2 A, CHO, COA, SO 2 NH 2 or SO 2 A, R 7 , R 8 , R 9 , R 10 each, independently of one another, denote H, A or —(CH 2 ) p —Ar, A denotes alkyl having 1 to 10 C atoms, where, in addition, 1-7 H atoms may be replaced by F and/or chlorine, m denotes 0, 1, 2, 3 or 4, n denotes 0 or 1, p denotes 0, 1, 2, 3 or 4, q denotes 0, 1, 2, 3 or 4, r denotes 0, 1, 2, 3 or 4, s denotes 0, 1, 2, 3 or 4, Hal denotes F, Cl, Br or I, and, if Ar 1 denotes piperazinediyl, R 6 may also denote H or alkyl having 1-6 C atoms, or a pharmaceutically acceptable tautomer, salt or stereoisomer thereof.