Patent ID: 7490603

Claim:
A method, comprising the steps of: (a) measuring a patient's glucose level; (b) aerosolizing a formulation comprising monomeric insulin; (c) inhaling the aerosolized formulation into the lungs of the patient, the formulation being inhaled with a first total inhaled volume; (d) allowing particles of formulation to settle in the lungs, migrate into the patient's circulatory system and thereby increase the concentration to a first maximum level in the patient's blood in a first period of time; (e) repeating the aerosolizing of a formulation comprised of monomeric insulin; (f) inhaling the aerosolized formulation of (e) into the lungs of a patient, the formulation being inhaled with a second total inhaled volume different from the first total inhaled volume; (g) allowing particles of formulation to settle in the lungs, migrate into the patient's circulatory system and thereby increase the concentration of formulation to a second maximum level in the patient's blood in a second period of time; whereby the difference between the first total inhaled volume and the second total inhaled volume effects the difference between the first maximum level of formulation and the second maximum level of formulation less than if the formulation were comprised of regular recombinant insulin.