Patent ID: 8703189

Claim:
A medicinal composition consisting essentially of a pharmacologically active substance, a low-melting-point substance and a pH-independent water-insoluble polymer, which is prepared by spraying a liquid substance obtained by dissolving or dispersing a pharmacologically active substance in a molten mixture containing a low-melting-point substance and a pH-independent water-insoluble polymer, and cooling the sprayed liquid substance, wherein the medicinal composition is a sustained release preparation or a fast release preparation, the low-melting-point substance is a glycerin behenic acid ester or a glycerin stearic acid ester, and the pharmacologically active substance is at least one member selected from the group consisting of theophylline, cilostazol, grepafloxacin, carteolol, procaterol, rebamipide and aripiprazole, the pH-independent water-insoluble polymer is a single substance or a mixture of two or more substances selected from the group consisting of ethylcellulose, aminoalkyl methacrylate copolymer RS, aminoalkyl methacrylate copolymer RL, cellulose acetate, cellulose acetate butyrate, and cellulose acetate propionate, and which contains the pH-independent water-insoluble polymer in the proportion of from 8.3 to 45 wt. % relative to the low-melting-point substance.