Patent ID: 7276608

Claim:
A compound of formula I including all pharmaceutically acceptable salts and stereoisomers, wherein: R 1 , R 3 and R 4 are each independently selected from the group consisting of hydrogen, alkyl, halo and CN; R 2 is selected from the group consisting of alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, OR 11 and OCF 2 H; R 5 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, COOR 13 and CONR 13 R 13a ; R 7 and R 7a are each independently selected from the group consisting of hydrogen, alkyl and cycloalkyl; R 9 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, arylalkyl and heteroarylalkyl; R 10 is selected from the group consisting of alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; R 11 is selected from the group consisting of aryl, heteroaryl and heteroarylalkyl; R 13 and R 13a are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 13 and R 13a taken together can form cycloalkyl or heterocyclyl; X is —(CR 14 R 14a ) n —; Y is independently selected from the group consisting of —S(O) 2 — and —SO 2 N(R 15 )—; R 14 and R 14a are each independently selected from the group consisting of hydrogen and alkyl; R 15 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 10 and R 15 taken together can form cycloalkyl or heterocyclyl; and n is an integer 0, 1 or 2, with the following provisos R 5 is neither imidazole nor substituted imidazole; when Y is —S(O) 2 —, R 10 is not a seven-membered lactam; and when Y is —SO 2 N(R 15 )—, neither R 10 nor R 15 is a seven-membered lactam.