Patent ID: 8431148

Claim:
A bone void filler comprising collagen, calcium phosphate, an effective amount of BMP-2 or a functional fragment thereof and at least one stabilizer agent comprising calcium sulfate, wherein: a dry weight of said collagen is between about 5% and about 30% of the weight of the bone void filler and said collagen comprises soluble collagen, and insoluble fibular collagen comprising collagen strands, wherein a dry weight of the soluble collagen is between about 20% and about 40% of the dry weight of the collagen; and a dry weight of the insoluble fibular collagen is between about 60% and about 80% of the dry weight of the collagen; a weight of said calcium phosphate is between about 55% and about 94% of the weight of the bone void filler and the calcium phosphate is provided in granules having a diameter of between 0.1 and 5 mm and the calcium phosphate comprises hydroxyapatite and tricalcium phosphate in a weight ratio of hydroxyapatite: tricalcium phosphate of about 15:85 to about 25:75; and a weight of said at least one stabilizer agent is between about 1% and about 15% of the weight of the bone void filler, wherein the filler is in the form of a putty and the stabilizer binds collagen strands together.