Patent ID: 8389006

Claim:
A method for forming a pharmaceutical composition, comprising: (a) providing a substrate having a surface area of at least 20 m 2 /g; wherein said substrate is selected from the group consisting of SiO 2 , TiO 2 , Al 2 O 3 , and zeolites, (b) adding said substrate to a solvent to form a suspension and agitating said suspension; (c) dissolving a low-solubility drug in said solvent; said low-solubility drug having a minimum aqueous solubility of less than 0.1 mg/ml at a pH of 1 to 8 and (d) rapidly removing said solvent from said suspension to form an adsorbate comprising said low-solubility drug adsorbed onto said substrate, wherein said solvent is rapidly removed so as to solidify said adsorbate within 100 seconds and wherein at least 80 wt % of said drug in said adsorbate is in amorphous form wherein said step of removing said solvent from said suspension is accomplished by spray-drying said suspension.