Patent ID: 7420061

Claim:
A method of preparing a compound of Formula II wherein A is isoxazolyl, wherein A is unsubstituted or substituted with one or more radicals selected from acyl, halo, hydroxy, C 1 -C 10 -alkyl, C 1 -C 6 -haloalkyl, oxo, cyano, nitro, carboxyl, C 1 -C 6 -alkoxy, aminocarbonyl, C 1 -C 6 -alkoxycarbonyl, carboxy-C 1 -C 10 -alkyl, C 1 -C 10 -cyanoalkyl, C 1 -C 10 -alkylcarbonyloxyalkyl, phenyl and C 1 -C 6 -hydroxyalkyl; wherein R 4 is selected from 5-6 membered heteroaryl and phenyl, wherein R 4 is unsubstituted or substituted with one or more radicals selected from C 1 -C 10 -alkyl, C 1 -C 10 -haloalkyl, cyano, carbonyl, C 1 -C 6 -alkoxycarbonyl, hydroxyl, C 1 -C 6 -hydroxyalkyl, C 1 -C 6 -haloalkoxy, amino, C 1 -C 6 -alkylamino, phenylamino, nitro, C 1 -C 10 -alkoxyalkyl, C 1 -C 6 -alkylsulfinyl, halo, C 1 -C 6 -alkoxy and C 1 -C 6 -alkylthio; and wherein R 5 is selected from hydrido, C 1 -C 10 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 10 -alkoxyalkyl, phenyl, C 1 -C 6 -alkoxycarbonylalkyl, C 1 -C 6 -alkoxycarbonyl, amino-C 1 -C 10 -alkyl, C 1 -C 6 -alkoxycarbonylaminoalkyl, and C 1 -C 10 -alkylcarbonylaminoalkyl; or a pharmaceutically-acceptable salt thereof; the method comprising reacting an unsubstituted sulfonamide with an acylating agent in the presence of base and a solvent.