Patent ID: 8450317

Claim:
A compound of formula (I): wherein: A is N; B is C; D is C; X is absent; R 1 is H or F; R 2 is benzoimidazolyl, benzooxazolyl, benzo[b]thiophenyl, dibenzofuranyl, dibenzothiophenyl, furanyl, imidazolyl, 1H-imidazo[4,5-c]pyridinyl, indolyl, isoindolyl, isoquinolinyl, isoxazolyl, oxazolyl, phenyl, pyranyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, thiadiazolyl, thiazolyl, thienyl or triazinyl, each optionally substituted with one to three R 6 ; R 3 is benzoimidazolyl, benzo[d]isothiazolyl, benzo[b]thiophenyl, benzotriazolyl, furanyl, imidazo[4,5-b]pyridinyl, imidazolyl, indazolyl, indolyl, isoindolyl, isoquinolinyl, isothiazolyl, phenyl, phthalazinyl, pyrazolyl, pyridinyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[3,2-c]pyridinyl, pyrrolo[3,2-b]pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrrolyl, quinazolinyl, thiadiazolyl or thiazolyl, each optionally substituted with one to three R 7 ; R 4 and R 5 are; each R 6 is independently —OH, oxo, hydroxyC 1-6 alkyl, halogen, —(CH 2 ) m —CN, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-6 alkoxy, phenoxy, pyridyloxy, C 1-6 alkoxycarbonyl, carboxyl, —C(O)C 1-6 alkyl, —(CH 2 ) m —NR 8 R 9 , —S(O) n C 1-6 alkyl, —NHS(O) 2 C 1-6 alkyl, —NHC(O)C 1-6 alkyl, —S(O) 2 NR 8 R 9 , —C(O)NR 8 R 9 , thienyl, morpholinyl, pyrrolidinyl, piperidinyl, [1,3]-oxazepan-1-yl, piperazinyl, azabicyclo[2.2.1]heptyl, 2-oxa-5-azabicyclo[2.2.1]heptyl, octahydroisoquinolinyl, [1,4]-oxazepanyl, azetidinyl phenyl or benzyl, wherein each alkyl, alkenyl or alkynyl of said R 6 is optionally partially or fully halogenated and each heterocyclyl, heteroaryl, phenyl or benzyl of said R 6 is optionally substituted with one to three CH 3 , —OCH 3 , halogen, —CN, —CF 3 , —C(O)CH 3 , NR 8 R 9 , —C(O)NH 2 , —C(O)NHCH 3 , —OH, —CH 2 OCH 3 , —C(OH)(CH 3 )CH 3 —SCH 3 , pyrrolidinyl or —S(O) 2 CH 3 ; each R 7 is independently C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-6 alkoxy, halogen, oxo, —CN, carboxy, —(CH 2 ) m —NR 8 R 9 , phenyl or pyridyl, wherein each alkyl, alkenyl or alkynyl of said R 7 is optionally partially or fully halogenated; R 8 and R 9 are each independently hydrogen, C 1-6 alkyl, C 1-6 acyl or C 3-10 cycloalkyl; m is an integer from 0 to 3; n is an integer from 0 to 2; and is a single bond; or a pharmaceutically acceptable salt thereof.