Patent ID: 7081462

Claim:
A compound represented by formula I: wherein: Z is N; Z 1 is N; R 1 is hydrogen or alkyl; R 2 is alkyl, hydroxyalkyl, optionally-substituted aralkyl, optionally-substituted cycloalkyl, heteroalkyl, optionally-substituted heterocyclyl, optionally-substituted aryl, or optionally-substituted heteroaryl; A is absent or —O—, —S(O) n —, —CHR′—, —C(═O)—, or —NR 3 —, wherein n is 0, 1, or 2, R′ is hydrogen or alkyl, and R 3 is hydrogen, alkyl, optionally-substituted aryl, optionally-substituted heteroaryl, or optionally-substituted cycloalkyl; the bond between atoms C5 and Z 1 is a single bond; the bond between atoms C8 and C9 is a single or double bond; and; and Y is an alkyl, heteroalkyl, optionally-substituted cycloalkyl, optionally-substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt or ester thereof.