Patent ID: 8027740

Claim:
A method of delivery of a therapeutic agent to a depth within the myocardium including the steps of: inserting a catheter into the heart, said catheter having a proximal end and a distal end, said catheter configured with a fixating penetrating element secured to the distal end thereof, said catheter having a therapeutic agent lumen extending from the proximal end to the distal end of the catheter, a therapeutic agent port at the distal end of the catheter communicating from the therapeutic agent lumen to the exterior of the catheter and a contrast delivery lumen extending from the proximal end to the distal end of the catheter and a contrast port communicating from the contrast agent lumen to the exterior of the catheter proximal to the fixating penetrating element; accessing the heart with the catheter percutaneously through a blood vessel of the patient and into an endocardial space in the heart, and manipulating the fixating penetrating element to engage and penetrate the heart wall and releasably connect the catheter distal tip to the heart wall; and infusing a therapeutic agent to a depth within the heart wall.