Patent ID: 7419975

Claim:
A compound according to formula I wherein R 1 is H; C 1 -C 4 alkyl; C 1 -C 4 alkenyl; C 1 -C 4 alkynyl or C 3 -C 10 cycloalkyl which are unsubstituted or substituted; R 2 is H; C 1 -C 4 alkyl; C 1 -C 4 alkenyl; C 1 -C 4 alkynyl or C 3 -C 10 cycloalkyl which are unsubstituted or substituted; R 3 is H; —CF 3 ; —C 2 F 5 ; C 1 -C 4 alkyl; C 1 -C 4 alkenyl; C 1 -C 4 alkynyl; —CH 2 -Z; Z is H; —OH; F; Cl; —CH 3 ; —CF 3 ; —CH 2 Cl; —CH 2 F or —CH 2 OH; R 4 is C 1 -C 16 straight or branched alkyl; C 1 -C 16 alkenyl; C 1 -C 16 alkynyl; or —C 3 -C 10 cycloalkyl; —(CH 2 ) 1-6 -Z 1 ; and —(CH 2 ) 0-6 -het; wherein cycloalkyl is unsubstituted or substituted; Z 1 is —N(R 8 )—C(O)—C 1 -C 10 alkyl; —N(R 8 )—C(O)—(CH 2 ) 1-6 —C 3 -C 7 cycloalkyl; —N(R 8 )—C(O)—(CH 2 ) 0-6 -phenyl; —N(R 8 )—C(O)—(CH 2 ) 1-6 -het; —C(O)—N(R 9 )(R 10 ); —C(O)—O—C 1 -C 10 alkyl; —C(O)—O—(CH 2 ) 1-6 —C 3 -C 7 cycloalkyl; —C(O)—O—(CH 2 ) 0-6 -phenyl; —C(O)—O—(CH 2 ) 1-6 -het; —O—C(O)—C 1 -C 10 alkyl; —O—C(O)—(CH 2 ) 1-6 —C 3 -C 7 cycloalkyl; —O—C(O)—(CH 2 ) 0-6 -phenyl; —O—C(O)—(CH 2 ) 1-6 -het; wherein alkyl, cycloalkyl and phenyl are unsubstituted or substituted; het is a 5-7 membered heterocyclic ring containing 1-4 heteroatoms selected from N, O and S, or an 8-12 membered fused ring system including at least one 5-7 membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, O, and S, which heterocyclic ring or fused ring system is unsubstituted or substituted on a carbon or nitrogen atom; R 8 is H; —CH 3 ; —CF 3 ; —CH 2 OH or —CH 2 Cl; R 9 and R 10 are each independently H; C 1 -C 4 alkyl; C 3 -C 7 cycloalkyl; —(CH 2 ) 1-6 —C 3 -C 7 cycloalkyl; —(CH 2 ) 0-6 -phenyl; wherein alkyl, cycloalkyl and phenyl are unsubstituted or substituted, or R 9 and R 10 together with the nitrogen form het; R 5 is H; C 1 -C 10 -alkyl; aryl; phenyl; C 3 -C 7 cycloalkyl; —(CH 2 ) 1-6 —C 3 -C 7 cycloalkyl; —C 1 -C 10 alkyl-aryl; —(CH 2 ) 0-6 —C 3 -C 7 cycloalkyl-(CH 2 ) 0-6 -phenyl; —(CH 2 ) 0-4 CH—((CH 2 ) 1-4 -phenyl) 2 ; —(CH 2 ) 0-6 —CH(phenyl) 2 ; -indanyl; —C(O)—C 1 -C 10 alkyl; —C(O)—(CH 2 ) 1-6 —C 3 -C 7 -cycloalkyl; —C(O)—(CH 2 ) 0-6 -phenyl; —(CH 2 ) 0-6 —C(O)-phenyl; —(CH 2 ) 0-6 -het; —C(O)—(CH 2 ) 1-6 -het; or R 5 is a residue of an amino acid, wherein the alkyl, cycloalkyl, phenyl and aryl substituents are unsubstituted or substituted; U is a bicyclic saturated or unsaturated ring system, consisting of all carbon skeleton or with one or more heteroatoms such as O, N, S but preferably as shown in structure III: wherein each of the ring carbons is unsubstituted, and m is 0-3; n=0-5; X or N; W is N; V is O, F 2 , Cl 2 , Br 2 , I 2 , S, YH, H 2 , NH, or C 1 -C 4 alkyl; or pharmaceutically acceptable salts thereof.