Patent ID: 8506979

Claim:
A method comprising: reducing the bacterial proton-motive force (Δp-plas-Bact) and the bacterial plasma transmembrane potential (ΔΨ-plas-bact) across a bacterial cell membrane in bacterial cells of a target site in order to inhibit bacterial cellular anabolic pathways and weaken resistance mechanisms against antibacterial molecules, the reducing step comprising: combining λn and Tn to irradiate a target site at a NIMELS dosimetry, concurrently reducing bacterial chemiosmotic electrochemical energy that is required for cellular anabolic reactions in bacteria at said target site; and simultaneously or sequentially administering an antibacterial agent or agents to said target site, co-targeting a cellular anabolic reaction or reactions, wherein inhibition of one or more cellular anabolic pathways at said target site is effectuated; wherein λn corresponds to irradiation at wavelengths in at least one of the wavelength range of about 865 nm to about 875 nm and the wavelength range of about 925 nm to about 935 nm; wherein Tn corresponds to a treatment time in the range of 50 seconds to about 1200 seconds; and wherein the NIMELS dosimetry corresponds to irradiation of the target site at a power density of about 0.25 W/cm 2 to about 40 W/cm 2 and an energy density of about 50 J/cm 2 to about 700 J/cm 2 .