Patent ID: 7396843

Claim:
A compound of formula (I): wherein X is abond; R 1 is selected from an optionally substituted five- to seven-membered heterocyclic ring, an optionally substituted five- to seven-membered heteroaryl ring and an optionally substituted fused bicyclic ring; R 2 is selected from hydrogen, C 1-6 alkyl and —(CH 2 ) p —C 3-7 cycloalkyl; or when X is a bond and m and n are both zero, R 1 and R 2 , together with the nitrogen atom to which they are bound, form a five- to six-membered heterocyclic ring optionally containing one additional heteroatom selected from oxygen and nitrogen, which can be optionally substituted by C 1-4 alkyl; R 3 is the group —CO—NH—(CH 2 ) q -R 4 ; when q is 0 to 2 R 4 is selected from hydrogen, C 1-6 alkyl, —C 3-7 cycloalkyl, CONHR 5 , phenyl optionally substituted by R 7 and/or R 8 , heteroaryl optionally substituted by R 7 and/or R 8 and heterocyclyl optionally substituted by R 7 and/or R 8 ; and when q is 2 R 4 is additionally selected from C 1-6 alkoxy, NHCOR 5 , NHCONHR 5 , NR 5 R 6 , and OH; R 5 is selected from hydrogen, C 1-6 alkyl and phenyl wherein the phenyl group may be optionally substituted by up to two substituents selected from C 1-6 alkyl and halogen; R 6 is selected from hydrogen and C 1-6 alkyl; or R 5 and R 6 , together with the nitrogen atom to which they are bound, form a five- to six-membered heterocyclic or heteroaryl ring optionally containing up to one additional heteroatom selected from oxygen, sulfur and nitrogen, wherein the ring may be substituted by up to two C 1-6 alkyl groups; R 7 is selected from C 1-6 alkyl, C 1-6 alkoxy, —CONR 6 R 9 , —NHCOR 9 , —SO 2 NHR 9 , —NHSO 2 R 9 , halogen, trifluoromethyl, -Z-(CH 2 ) s —phenyl optionally substituted by one or more halogen atom, -Z-(CH 2 ) s —heterocyclyl or -Z-(CH 2 ) s —heteroaryl wherein the heterocyclyl or heteroaryl group may be optionally substituted by one or more substituents selected from C 1-6 alkyl; R 8 is selected C 1-6 alkyl and halogen; or when R 7 and R 8 are ortho substituents, then together with the carbon atoms to which they are bound, R 7 and R 8 may form a five- or six-membered saturated or unsaturated ring to give a fused bicyclic ring system, wherein the ring that is formed by R 7 and R 8 may optionally contain one or two heteroatoms selected from oxygen, nitrogen and sulfur; R 9 is selected from hydrogen and C 1-6 alkyl; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each selected independently from hydrogen, methyl and halogen; Z is selected from —O—and a bond; m and n are independently selected from 0, 1 and 2, wherein each carbon atom of the resulting carbon chain may be optionally substituted with up to two groups selected independently from C 1-6 alkyl, and the sum of m+n is from 0 to 4; p is selected from 0 and 1; q and s are selected from 0, 1 and 2; r is selected from 0, 1 and 2; or a pharmaceutically acceptable salt or solvate thereof.