Patent ID: 8008481

Claim:
A compound of Formula (I) wherein R 1 is selected from the group consisting of H, benzyl substituted with OCH 3 , optionally substituted (C 1 -C 3 )alkyl, pyrimidine substituted with NH 2 and amino(C 1 -C 3 )alkyl; R 3 is selected from the group consisting of H, halogen, NH 2 , OH, COOH, —C(O)—NH—CH 2 —C(O)—OCH 3 , —NH—CH 2 -phenyl, —C(O)-pyridinyl, —NH—C(O)-cyclobutyl and —NH—C(O)-phenyl wherein phenyl is optionally substituted with either N(CH 3 ) 2 or OCH 3 ; or R 3 is selected from the optionally substituted group consisting of (C 1 -C 6 )alkyl, benzo[b]thienyl, 2,3-dihydrobenzofuranyl, indolyl, isoquinolinyl, morpholinyl, naphthyl, phenyl, piperazinyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl and thienyl; wherein the substituent is selected from one or more CH 3 , NH 2 , Cl, F, dimethylamino, OH, CH 2 OH, —C(O)NH 2 , COOH, CF 3 , isopropyl, OCF 3 , OCH 3 , —O—CH 2 -phenyl, CN, OCH 2 CH 3 , —NH—C(O)-cyclobutyl, —NH—C(O)-phenyl, NH—C(O)—CH 3 , NHC(O)CH 3 , N(CH 3 ) 2 , S(O) 2 CH 3 and C(O)NH-phenyl; or R 3 is —C(O)—NY 100 —(C(Y 100 ) 2 ) x —R a wherein x is 0, 1, 2 or 3; Y 100 is independently H or (C 1 -C 3 )alkyl; and R a is —C(O)—CH 3 or is selected from the optionally substituted group (C 1 -C 3 )alkyl, amino, aminoalkyl, benzimidazolyl, benzo[b]thienyl, benzotriazolyl, biphenyl, 1,3-dihydrobenzimidazolyl, 1,3-dihydrobenzimidazolyl-2-one, imidazolyl, indolyl, naphthyl, phenyl, pyrazolyl, pyridinyl, pyrimidinyl, tetrahydropyranyl and thiazolyl; or R 3 is A-B wherein A is connected to the indazole and A is selected from the group consisting of —C≡C, —C≡C phenyl indazolyl, phenyl, pyridinyl and thienyl; B is selected from the group consisting of benzyloxy, morpholinyl, phenyl, thienyl, t-butyl, —NH—C(O)-cyclobutyl and —NH—C(O)-phenyl; R 4 is H or NH 2 ; R 5 is selected from the optionally substituted group consisting of benzimidazolyl, 3,4-dihydrobenzo[1,4]thiazinyl, furo[3,2-c]pyridine, indazolyl, indolyl, isoquinolinyl, pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[2,3-d]pyridinyl, pyrrolo[3,2-d]pyridine, pyrrolo[2,3-d]pyrimidinyl, quinolinyl, quinazolinyl, thieno[2,3-c]pyridinyl, thieno[2,3-d]pyrimidine, thieno[3,2-c]pyridine, 7-azaindolinyl and 7-azaindolyl; R 6 is H or R 6 is selected from the optionally substituted group consisting of (C 1 )alkoxy, (C 1 -C 3 )alkyl, benzo[b]thienyl, NH pyrimidinyl —NH—S(O) 2 -phenyl-NH-pyrimidinyl, —NH—C(O)-benzo[b]thienyl, pyrrolo[2,3-b]pyrimidinyl and pyridinyl; and R 7 is selected from optionally substituted group consisting of benzofuranyl, benzothiazolyl, benzo[b]thienyl, indolyl, isoquinolinyl, quinolinyl, quinoxalinyl, and thieno[2,3-b]pyridinyl; or R 7 is Y—Z wherein Y is attached to the indazole; and Y is benzo[b]thienyl; and Z is selected from the group consisting of phenyl, thienyl, CH 2 NHCH 2 CH 2 -morpholinyl and substituted piperazinyl.