Patent ID: 8735081

Claim:
A functional heteromeric T1R2/T1R3 receptor comprising a T1R2 subunit and a T1R3 subunit, wherein the T1R2 subunit comprises a Venus Flytrap Domain that has at least 90% sequence identity to amino acid residues 1 to 560 of the human T1R2 polypeptide in SEQ ID NO: 6 and a transmembrane domain and C-terminal domain each having at least 90% sequence identity to the transmembrane and C-terminal domains of a rat T1R1, T1R2 , T1R3 , or mGluR1 polypeptide, and wherein the T1R3 subunit comprises at least 90% sequence identity to the human T1R3 polypeptide in SEQ ID NO: 7.