Patent ID: 8343963

Claim:
A compound of the formula (I) or a physiologically acceptable salt thereof, or a mono-, di-, tri- or tetrahydrate of said compound or said salt, wherein R a is hydrogen; R b and R c together form a 5- or 6-membered saturated heterocycloalkyl ring, which contains one or more ring heteroatoms each selected from the group consisting of O, S and N, and which has 0 or 1 substituents R″, and which is optionally substituted by 1 or 2 oxo groups; R′ independently represents hydrogen, —CO 2 R″, —CONHR″, —CR″O, —SO 2 N(R″) 2 , —SO 2 NHR″, —NR″—CO-haloalkyl, —NO 2 , —NR″—SO 2 -haloalkyl, —NR″—SO 2 -alkyl, —SO 2 -alkyl, —NR″—CO-alkyl, —CN, alkyl, cycloalkyl, amino, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkoxy, aryl, haloaryl, haloarylalkyl, arylalkyl, heterocyclyl or heteroaryl; R″ independently represents hydrogen, —(CH 2 ) m R′, —CO 2 R′, —CON(R′) 2 , —CR′O, —SO 2 N(R″) 2 , —NR′—CO-haloalkyl, —NO 2 , —NR′—SO 2 -haloalkyl, —NR′—SO 2 -alkyl, —NR′—SO 2 -aryl, —NR′—SO 2 -heteroaryl, —SO 2 -alkyl, —SO 2 -aryl, —SO 2 -heteroaryl, —NR′—CO-alkyl, —NR′—CO-aryl, —NR′—CO-heteroaryl, —NR′—CO—N(R′) 2 , —CN, alkyl, amino, aminoalkyl, alkylamino, alkoxy, alkoxyalkyl, hydroxyl, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, or haloalkoxy; R 1 and R 2 represent hydrogen; m is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; X is N, R 3 is hydrogen; and R 4 is arylalkyl or aryl, which is optionally substituted with R″.