Patent ID: 7060683

Claim:
A method for the treatment of stroke comprising administering to a subject in need of such treatment an effective amount of a compound of the Formula I: wherein: W is A-B-D; A is aryl(CH 2 ) n , heteroaryl(CH 2 ) n , alkyl having from one to 14 carbons, alkenyl having from two to 14 carbons, or cycloalkyl having from 3 to 10 carbons, said A group being optionally substituted with one or more J groups; B is a bond or CO, SO, SO 2 , OCO, NR 5 CO, NR 5 SO 2 , or NR 5 SO; D is a bond, an amino acid residue, or a peptide composed of 2 to 5 amino acid residues, said amino acid residue(s) being independently defined by the formula —NH-**CH(R 6 )—CO—, in which ** denotes the α carbon of an α-amino acid residue possessing, when R 6 is other than hydrogen, the D-configuration, the L-configuration, or a mixture of D- and L-; n is an integer from 0 to 6; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are, independently, hydrogen, alkyl having from one to about 14 carbons, or cycloalkyl having from 3 to about 10 carbons, said alkyl, and cycloalkyl groups being optionally substituted with one or more J groups; and J is halogen, lower alkyl, aryl, heteroaryl, haloaryl, amino optionally substituted with one to three aryl or lower alkyl groups, guanidino, alkoxycarbonyl, amido, lower alkylamido, sulfonamido, lower alkyl sulfonamido, lower alkylsulfonyl, lower alkylsulfoxy, lower alkylthio, lower alkoxy, aryloxy, arylalkyloxy, hydroxy, carboxy, cyano, or nitro; and * denotes the α carbon of an α-amino acid residue possessing, when R 2 is other than hydrogen, the D-configuration, the L-configuration, or a mixture of the D- and L-configurations.