Patent ID: 8177775

Claim:
An apparatus comprising: a. an extracorporeal solvent reservoir comprising a distal portion, a proximal port and a lumen extending there-through; b. an extracorporeal portable pump comprising a proximal port and a distal port and a lumen therethrough wherein the extracorporeal portable pump is in fluid communication with the extracorporeal solvent reservoir; c. an infusion catheter configured for insertion into the tumor of the subject, the infusion catheter comprising a length extending from a proximal end for introduction into the tumor to a distal end with a lumen extending between the proximal end and the distal end wherein the infusion catheter is in fluid communication with the solvent reservoir and portable pump; d. an intracorporeal access port comprising an access port casing, two or more access port chambers defined within the casing, each access port chamber having a proximal port, a distal port and a lumen extending therebetween, a pliable septum covering the distal port of each chamber, wherein the intracorporeal access port is located proximal from the extracorporeal portable pump and facilitates fluid communication between (i) the extracorporeal solvent reservoir and extracorporeal portable pump, and (ii) the infusion catheter; and e. means for convection enhanced delivery of a solvent to a target tumor, wherein the solvent delivered by convection enhanced delivery has (i) a flow rate at the target tumor of more than 0.001 ml/h and less than 1 ml/h; (ii) a total flow volume within one period of any oscillation of less than about 0.5 μl; and (iii) an amplitude of oscillation between about 0.05 ml/h and about 1 ml/h.