Patent ID: 7482130

Claim:
A method for identifying a compound that modulates a ubiquitin ligase activity of an NP95 polypeptide, the method comprising the steps of: (i) contacting the compound with the NP95 polypeptide, wherein the NP95 polypeptide comprises an amino acid sequence with at least 90% identity to amino acids 737-775 of SEQ ID NO:2, and wherein the NP95 protein has ubiquitin ligase activity; (ii) determining the effect of the compound upon the ubiquitin ligase activity of the NP95 polypeptide; wherein a difference in ubiquitin ligase activity in the presence of the compound as compared with in the absence of the compound indicates that the compound modulates the ubiquitin ligase activity of the NP95 polypeptide.