Patent ID: 7183059

Claim:
A method for generating a compound having at least one biological activity of a peptide comprising: providing a first monomer, wherein said first monomer is diversifiable and contains first and second terminal reactive moieties, L 11 and L 12 , respectively, and at least one functionalizable group R 1 , R 2 , R 3 , X 1 , X 3 , L, L 11 or L 12 ; providing a second monomer, wherein said second monomer is diversifiable and contains third and fourth terminal reactive moieties, L 21 and L 22 , respectively, and at least one second functionalizable group R 1 , R 2 , R 3 , X 2 , X 4 , L, L 21 or L 22 ; wherein the first monomer is of the formula wherein L 11 and L 12 are each independently selected from hydrogen, protecting group, alkene, alkyne, amine, carboxylic acid, halogenated aromatic, aldehyde, vinyl halide; R 1 , R 2 and R 3 are selected from the group consisting of hydrogen, alkyl, aryl, phenoxy, methoxy, halide, methylene cyclohexyl, benzyl, heteroaryl, aryloxy, carboxyl, carboxalkyl, carboxaryl, arylalkyl, thiol and hydroxyl; L comprises a linking group; X 3 comprises a functional moiety selected from carboxyl, amino, gem-dialkyl, and methylene; and X 1 comprises a functionality containing oxygen, sulfur or carbon, having a predefined stereochemical relationship, wherein the second monomer is of the formula wherein L 21 , and L 22 are each independently selected from hydrogen, protecting group, alkene, alkyne, amine, carboxylic acid, halogenated aromatic, aldehyde, vinyl halide; R 1 , R 2 and R 3 are selected from the group consisting of hydrogen, alkyl, aryl, phenoxy, methoxy, halide, methylene cyclohexyl, benzyl, heteroaryl, aryloxy, carboxyl, carboxalkyl, carboxaryl, arylalkyl, thiol and hydroxyl; L comprises a linking group; X 4 comprises a functional moiety selected from carboxyl, amino, gem-dialkyl, and methylene; and X 2 comprises a functionality containing oxygen, sulfur or carbon, having a predefined stereochemical relationship; and reacting, under stereo- and/or regio-chemically controlled carbon-carbon bond formation reaction conditions, said first monomer with said second monomer to yield a compound in which the monomers are attached to one another by way of the second (L 12 ) and third terminal (L 21 ) reactive moieties, such that the compound has at least one biological activity of a peptide.