Patent ID: 7642323

Claim:
A polymer derivative comprising the formula: wherein: X is selected from the group consisting of: hydroxyl; mesylate; tosylate; tresylate; —O—(CH 2 ) n —CO 2 H wherein (n) is a number of 1-6; —O—(CH 2 ) n —CO 2 R 3 wherein (n) is a number of 1-6 and R 3 is an alkyl group; —NHR 4 wherein R 4 is H or alkyl or an amine protecting group; —O—(CH 2 ) n —CH(ZR 5 ) 2 wherein (n) is a number of 1-6, Z is O or S, and R 5 is H or an alkyl group; Ar—CH═CH—CH═CH—CO 2 —, where Ar represents a moiety selected from the group consisting of phenyl, biphenyl, polycyclic aryls, and heterocyclic aryls; —O—(CH 2 ) n —CHO wherein (n) is a number of 1-6; and —O 2 CCH 2 CH 2 CO 2 R 6 , wherein R 6 is H or N-succinimidyl; POLY is a poly(ethylene glycol) having the formula —CH 2 CH 2 —O—(CH 2 CH 2 O) n′ —CH 2 CH 2 — and (n′) is from about 45 to about 4000; (p) is zero or a number of 1-6; (q) is zero of a number of 1-6; (r) is either zero or one, wherein if (r) is one, the polymer derivative has a positive charge; each R 10 , when present, is independently H or and alkyl group; each R 11 , when present, is independently H or and alkyl group; each R 12 , when present, is independently H or and alkyl group; each R 13 , when present, is independently H or and alkyl group; R 14 is H or methyl or ethyl; R 15 , when present, is H, methyl or ethyl; and Ar′ is a moiety selected from the group consisting of phenyl, biphenyl, polycyclic aryls, and heterocyclic aryls; —O—(CH 2 ) n —CHO wherein (n) is a number of 1-6; and —O 2 CCH 2 CH 2 CO 2 R 6 , wherein R 6 is H or N-succinimidyl, and salt forms thereof.