Patent ID: 8551950

Claim:
A method for the treatment of an inflammatory pain in a subject, comprising administering to the subject an effective amount of an AT 2 receptor antagonist; wherein the AT 2 receptor antagonist is selected from compounds represented by the formula (I): wherein: R 1 and R 2 are independently selected from H, benzyl, substituted benzyl, phenyl, substituted phenyl, C 1-6 alkyl, substituted C 1-6 alkyl, C 3-6 cycloalkyl, substituted C 3-6 cycloalkyl, and heteroaryl, providing that both R 1 and R 2 are not hydrogen, R 4 is selected from a carboxylate, carboxylic acid, sulfate, phosphate, sulfonamide, phosphonamide or amide, X is selected from CH, nitrogen, sulfur or oxygen with the proviso that when X is sulfur or oxygen one of R 1 or R 2 is absent, Y is selected from sulfur, oxygen or N—R N , where R N is selected from H, C 1-6 alkyl, substituted C 1-6 alkyl, aryl, substituted aryl, benzyl, substituted benzyl, C 1-4 alkylaryl, substituted C 1 -4 -alkylaryl, OH, or NH 2 , G is selected from one of the following rings systems: where the symbol ‘*’ indicates the bond shared between the fused rings ‘A’ and ‘G’, R 5 is selected from H, C 1-6 alkyl, phenyl, substituted phenyl, substituted C 1-6 alkyl, C 1-6 alkoxy, or substituted C 1-6 alkoxy, R 6 and R 8 are independently selected from H, C 1-6 alkyl, substituted C 1-6 alkyl, C 1-6 alkoxy, substituted; C 1-6 alkoxy, phenyl, phenyloxy, benzyl, benzyloxy, benzylamino, biphenyl, substituted biphenyl, biphenyloxy, substituted biphenyloxy, naphthyl, substituted naphthyl, provided that one of R 6 or R 8 is not hydrogen, and R 7 is selected from phenyl, substituted phenyl, benzyl, substituted benzyl, biphenyl, substituted biphenyl, biphenylmethylene, substituted biphenylmethylene, naphthyl, substituted naphthyl, naphthylmethylene, and substituted naphthylmethylene, or a pharmaceutically acceptable salt thereof.