Patent ID: 8403979

Claim:
A valve prosthesis for implantation in a body vessel having a vessel wall, said valve prosthesis comprising: an implantable frame radially-expandable from a compressed configuration to an expanded configuration having an interior lumen, the frame defining a laterally asymmetric partial sinus portion of the interior lumen extending around between about 10% and about 90% of the circumference of the frame in the expanded configuration; and a valve member; wherein the frame includes a proximal portion, a distal portion, and an intermediate portion; the valve member comprising at least one leaflet operatively attached to the frame, the at least one leaflet having a base and a free edge and being movable between a first position to permit fluid flow through said body vessel in a first direction and a second position to form a valve pocket that collects fluid and substantially prevents fluid flow through said body vessel in a second direction that is opposite the first direction; the partial sinus portion of the interior lumen being defined by a bulge of the intermediate portion in a lateral direction such that the bulge of the intermediate portion has a width greater than the width of the distal portion and the proximal portion; wherein the at least one leaflet forms a seal with a first portion of said vessel wall opposite the bulge of the intermediate portion of the frame and cooperatively defines the valve pocket with a second portion of said vessel wall of said body vessel adjacent the bulge of the intermediate portion when the at least one leaflet is in the second position.