Patent ID: 7803793

Claim:
A compound of Formula (I): wherein Ring a is a 7, -membered heterocyclyl consisting of 6 carbons and one nitrogen, wherein X is O E is selected from an wherein R 5 is selected from H, hydroxy, amino, alkoxy, alkylthio, sulfonyl, C 1-10 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, and heterocyclyl, and Q is N; Ring b is selected from aryl; heteroaryl; and heterocyclyl of the formula wherein G 1 and G 2 are independently selected from N, C, and CH; and D 1 and D 2 are each 1-3 independent members selected from CH, CH 2 , N, S, and O, provided that when G 1 or G 2 is N, D 1 and D 2 are independently selected from CH and CH 2 ; R 1 is selected from halo, nitrile, hydroxyl, thiol, amino, alkoxy, alkylthio, sulfonyl, C 1-10 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, carbonyl, and —CHO; R 2 is 0-2 independent members selected from halo, nitrile, hydroxyl, amino, C 1-10 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, alkoxy, alkylthio, sulfonyl, aryl, heteroaryl, heterocyclyl, —C(O)R 3 , —C(O)OR 3 , and —C(O)NR 3 R 4 , wherein R 3 and R 4 are independently selected from H, C 1-10 alkyl, aryl, heteroaryl, and heterocyclyl, or R 3 and R 4 together with the N they are attached to form a 3-, 4-, 5-, 6-, or 7-membered heterocyclyl; W is selected from a covalent bond, —(CH 2 ) p —O—, —O—(CH 2 ) p —, —S(O) p —, —C(O)—, C 1-3 alkylene, C 2-3 alkenylene, C 2-3 alkynylene, and 5-7 membered aliphatic ring containing one or two nitrogens, wherein p is 0, 1, or 2; Y is selected from O, S, S(O), S(O) 2 , —SO 2 N(R 6 )—, —N(R 6 ) SO 2 —, —N(R 6 ) SO 2 N(R 7 )—, —N(R 6 )CO—, —N(R 6 )PO(OR 8 )—, —N(SO 2 R 8 )—, —N(COR 8 )—, —N(POOR 8 R 9 )—, —CH(OH)—, wherein R 6 and R 7 are independently selected from H, C 1-10 alkylsulfonyl, arylsulfonyl, alkylcarbonyl, and arylcarbonyl, and R 8 and R 9 are independently selected from C 1-6 alkyl, aryl, heteroaryl, and heterocyclyl; Z is —CH(R 10 )— or —CH(R 10 )CH(R 11 )—, wherein R 10 and R 11 are independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, and heterocyclyl; m is 0, 1, or 2; and n is 0 or 1 with the proviso that when n is 0, E is not N and Y is not O; or an optical isomer, enantiomer, diastereomer, racemate, prodrug or pharmaceutically acceptable salt thereof.