Patent ID: 8124601

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is a -5,5-, -5,6-, -5,7-, -6,6-, -6,7-, or -7,7- spirocyclic diamine attached to the carbonyl through one nitrogen and substituted with 0-3 R 8 substituents; R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 )(R 10 )NSO 2 , or (R 11 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is oxo, hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, (cycloalkyl)carbonyl, alkoxycarbonyl, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, (R 12 )carbonyl, benzyl, or benzyloxycarbonyl; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; and R 12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; or a pharmaceutically acceptable salt thereof.