Patent ID: 7927591

Claim:
An isolated antibody comprising an immunoglobulin heavy chain (HC) variable domain and an immunoglobulin light chain (LC) variable domain, wherein the HC variable domain and the LC variable domain form an antigen binding site that binds to an activated conformation of LFA-1, wherein the antibody comprises: (i) a heavy chain variable domain that comprises (a) a CDR1 that comprises RYVMW (SEQ ID NO:1); (b) a CDR2 that comprises YIWPSGGNTYYADSVKG (SEQ ID NO:2); and (c) a CDR3 that comprises a sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ ID NO:56 and SEQ ID NO:57; and a light chain variable domain that comprises (d) a CDR1 that comprises RASQSIGSYLN (SEQ ID NO:7); (e) a CDR2 that comprises AASSLQS (SEQ ID NO:8); and (f) a CDR3 that comprises QQSYSTPS (SEQ ID NO:9); or (ii) a heavy chain variable domain that comprises SEQ ID NO:23, SEQ ID NO:25, SEQ ID NO:27, or SEQ ID NO:29; and a light chain variable domain that comprises SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, or SEQ ID NO:28; or (iii) a heavy chain variable domain that comprises a sequence encoded by a nucleic acid that hybridizes under high stringent conditions to the complement of the full length of SEQ ID NO:42, SEQ ID NO:43, or SEQ ID NO:44; and a light chain variable domain that comprises a sequence encoded by a nucleic acid that hybridizes under high stringent conditions to the complement of the full length of SEQ ID NO:39, SEQ ID NO:40, or SEQ ID NO:41; or (iv) an antibody selected from the group consisting of a) an immunoglobulin heavy chain variable domain sequence comprising SEQ ID NO:23, and an immunoglobulin light chain variable domain sequence comprising SEQ ID NO:22; b) an immunoglobulin heavy chain variable domain sequence comprising SEQ ID NO:25, and an immunoglobulin light chain variable domain sequence comprising SEQ ID NO:24; c) an immunoglobulin heavy chain variable domain sequence comprising SEQ ID NO:27, and an immunoglobulin light chain variable domain sequence comprising SEQ ID NO:26; and d) an immunoglobulin heavy chain variable domain sequence comprising SEQ ID NO:29, and an immunoglobulin light chain variable domain sequence comprising SEQ ID NO:28; for binding to activated LFA-1.