Patent ID: 8420087

Claim:
A compound comprising a target specific portion and an effector portion wherein: (i) the target specific portion comprises a monoclonal antibody having specificity for oncofoetal fibronectin, or a fragment or variant thereof which retains the binding specificity for oncofoetal fibronectin of the parent monoclonal antibody; and (ii) the effector portion comprises interleukin-12, or a functional fragment or variant thereof; wherein the target specific portion is capable of binding an amino acid sequence within the repeat 7 domain of fibronectin, wherein the compound comprises one or more polypeptides selected from the group consisting of the polypeptide of SEQ ID NO: 6 and the polypeptide of SEQ ID NO: 7, and wherein SEQ ID NO: 6 includes SEQ ID NO: 1 and SEQ ID NO: 3; and SEQ ID NO: 7 includes SEQ ID NO: 2.