Patent ID: 8445487

Claim:
A method of treating cancer in a mammal comprising administering to said mammal a therapeutically effective amount of a compound having the structure: and stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R 1 is selected from H, C 1 -C 12 alkyl, and —(C 1 -C 12 alkylene)-(C 2 -C 20 heterocyclyl), where alkyl, alkylene, and heterocyclyl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CH 3 , —CH 2 OH, —CN, —CF 3 , —CO 2 H, —COCH 3 , —CO 2 CH 3 , —CONH 2 , —CONHCH 3 , —CON(CH 3 ) 2 , —NO 2 , —NH 2 , —NHCH 3 , —NHCOCH 3 , —NHS(O) 2 CH 3 , —OH, —OCH 3 , —S(O) 2 N(CH 3 ) 2 , —SCH 3 , —CH 2 OCH 3 , and —S(O) 2 CH 3 ; R 2 is selected from C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, —(C 1 -C 12 alkylene)-(C 3 -C 12 carbocyclyl), —(C 1 -C 12 alkylene)-(C 2 -C 20 heterocyclyl), —(C 1 -C 12 alkylene)-C(═O)—(C 2 -C 20 heterocyclyl), —(C 1 -C 12 alkylene)-(C 6 -C 20 aryl), and —(C 1 -C 12 alkylene)-(C 1 -C 20 heteroaryl), where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CH 3 , —CH 2 OH, —CN, —CF 3 , —CO 2 H, —COCH 3 , —CO 2 CH 3 , —CONH 2 , —CONHCH 3 , —CON(CH 3 ) 2 , —NO 2 , —NH 2 , —NHCH 3 , —NHCOCH 3 , —NHS(O) 2 CH 3 , —OH, —OCH 3 , —S(O) 2 N(CH 3 ) 2 , —SCH 3 , —CH 2 OCH 3 , and —S(O) 2 CH 3 ; and R 3 is a monocyclic heteroaryl selected from: where the wavy line indicates the site of attachment; wherein the cancer is selected from prostate cancer and breast cancer.