Patent ID: 7511046

Claim:
A compound of Formula I: a pharmaceutically acceptable salt or stereoisomer thereof, wherein X is N(CH 3 ) or O; R 1 is OH or C 1-6 alkoxy; R 2 is H or C 1-6 alkyl; R 3 is (CH 2 ) n Q, CH 2 CH(OH)Q, CH(CH 3 )Q, 1,2,3,4-tetrahydronaphthyl, indanyl, or adamantyl, wherein Q is thienyl, phenyl, furanyl, naphthyl, pyridyl, indolyl, indazolyl, cyclohexyl, 1,2-methylenedioxyphenyl, cyclohexenyl, 1H-pyrazolo[4,3-c]pyridyl, and Q is optionally substituted with one or two moieties independently selected from halo, C 1-6 alkyl, C 1-6 alkoxy, hydroxy, S(O) 2 NH 2 , trifluoromethyl, or cyano, and n is 1 or 2; R 4 is H or C 1-6 alkyl; or R 3 and R 4 , together with the nitrogen atom to which R 3 and R 4 are attached, form 1,4-dioxa-8-azo-spiro[4.5]decanyl, piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, azocanyl, 1,2,3,4-tetrahydroisoquinolinyl, 1,2,3,4-tetrahydro-Î²-carbolinyl, 4,5,6,7-tetrahydrothienyl[3,2-c]pyridyl, or 8-aza-bicyclo[3.2.1.]octane, each of which may be mono- or independently di-substituted with halo, C 1-6 alkyl, C 1-6 alkoxy, C(O)phenyl, OH, CN, O-phenyl or (CH 2 ) m Z, Z is benzisoxazolyl, indazolyl, benzisothiazolyl, benzothienyl, pyrimidinyl, pyridyl, 1,2-methylenedioxyphenyl, or phenyl, and Z, CH(OH)phenyl or O-phenyl are optionally substituted with one or two moieties independently selected from halo, C 1-6 alkyl, C 1-6 alkoxy, hydroxy, trifluoromethyl, S(O) 2 NH 2 , or cyano, and m is 0 or 1; provided that when R 1 is OH, R 2 is H: (1) R 4 is H, and R 3 is (CH 2 ) n Q, where n is 1 or 2, then Q cannot be indolyl or phenyl; or (2) R 3 and R 4 form piperazinyl substituted with (CH 2 ) m Z, when m is 1, then Z cannot be phenyl.