Patent ID: 7452524

Claim:
A method for improvement of tolerance for and enhanced deposition of a therapeutically effective agent delivered into lungs of a human subject in need thereof by inhalation, said method comprising step of: treating said human subject with an aerosol consisting essentially of about 10 mg, 40 mg or 100 mg of lidocaine or lidocaine-like substituted acetanilide and benzamide compound aerosolized into an aerosol having particles with mass median aerodynamic diameter (MMAD) between 2 μm and 5 μm for targeted delivery into lower lungs, between 4 μm and 5 μm for targeted delivery into central lungs, and between 0.1 μm and 2 μm for targeted delivery into a systemic circulation, using an electronic nebulizer modified with a vibrating perforated membrane having an output from about 0.48 ml/minute to about 0.60 ml/minute and generating an aerosol with a monodisperse particle spectrum of said particles having a geometric standard deviation lower than 1.7; wherein said lidocaine or lidocaine-like substituted acetanilide or benzamide compound is dissolved in from about 1 ml to about 3 ml of saline having pH adjusted to between 5.0 and 7.5, osmolality between 150 and 550 mOsm/kg, permanent anion concentration between 31 and 300 mM of chloride, and viscosity lower than 1.5 centipoise, and aerosolized and delivered into lungs of the human subject in from about 1 to about 3 minutes, concurrently with, immediately before or within 30 minutes before inhalation of the therapeutically effective agent, wherein said treatment results in improved tolerance and enhanced deposition of said agent without occurrence of bronchospasm, numbing of pharyngeal area, loss of gagging reflex and tracheal aspiration; and wherein said therapeutically effective agent is selected from the group consisting of α-proteinase-inhibitor, amikacin, carbenicillin, ceftazidim, colistin, gentamycin, imipenem, ticarcillin, penicillin, tobramycin, vancomycin, aztreonam, fosfomycin, rifampicin, ciprofloxacin, guinolone, glutathion, pentamidine, nifedipine, verapamil, amiloride, benzamil, furosemide, piretanid, torasemid, heparin, cyclosporine, methotrexate, azathoprine, mycophenoline, sirolimus, tacrolimus, mofetil, α-interferone, β-interferone, γ-interferone, interleukin 2, adrenaline, retinoic acid, amphotericin B, cefoperazone, ciproflaxine, fentanyl, fusafungin, DNA, magnesium sulfate, dextrane, dornase α, hypertonic saline, mannitol, N-acetylcystein, nitroglycerine, nitroprusside sodium, morphine, prostaglandin, indomethacin, aminophylline, ribavirine and human growth factor.