Patent ID: 7041300

Claim:
A porcine vaccine against a pathogen of interest, wherein the vaccine comprises a helper virus, at least one recombinant virion, and a pharmaceutical excipient, wherein the recombinant virion(s) comprises: (A) at least 1.9 kb of the 5′ end of a TGEV genome; (B) the pseudoknot region, including the region of overlap between ORFs 1a and 1b, of the TGEV genome; (C) defective or missing S, M, and N structural genes of the TGEV genome; (D) at least bp 9691-9707 of the 3′ end of the TGEV genome; and (E) at least one heterologous gene sequence encoding an antigen of the pathogen of interest inserted under the control of the S gene promoter of the TGEV genome.