Patent ID: 7129252

Claim:
Six membered amino-amide compound of formula (I) Wherein X is O or S; Y is —N(R 4 )—; Z 1 , Z 2 , Z 3 and Z 4 are independently CR 5 or N; A is selected from direct bond, lower alkylenyl and lower alkenlenyl; B is selected from direct bond, lower alkylenyl, lower alkenlenyl, —O—, —N(R 4 )—, —C(O)N(R 4 )—, —OC(O)N(R 4 )—, —N(R 4 )C(O)—, —N(R 4 )C(O)O—, —N(R 4 )C(O)N(R 4 )—, —(O)—, —S(O)—, —S(O) 2 —, —S(O)N(R 4 )—, —S(O) 2 N(R 4 )—, —N(R 4 )S(O)—, —N(R 4 )S(O) 2 —, —N(R 4 )S(O)N(R 4 )—, —N(R 4 )S(O) 2 N(R 4 )—; R 1 is selected from cycloalkyl, cycloalkenyl, aryl and heterocyclyl; Cy is selected from cycloalkyl, cycloalkenyl and heterocyclyl; R 2 is selected from halogen-lower alkyl, lower alkyl, lower alkenyl, lower alkynyl, C 0 –C 6 cyano, C 0 –C 6 hydroxy, C 0 –C 6 alkoxy, C 0 –C 6 alkoxyalkoxyl, C 0 –C 6 amino, C 0 –C 6 alkoxyamino, C 0 –C 6 carboxy, C 0 –C 6 carboxyalkyl, C 0 –C 6 carbonylamino, C 0 –C 6 carbonylalkyl, C 0 –C 6 oxycarbonylalkyl, C 0 –C 6 oxycarbonylamino, C 0 –C 6 aminocarbonylalkyl, C 0 –C 6 aminocarbonyloxyalkyl, C 0 –C 6 aminocarbonylamino, C 0 –C 6 aminosulfonylalkyl, C 0 –C 6 cycloalkyl, C 0 –C 6 cycloalkenyl, C 0 –C 6 aryl, C 0 –C 6 oxyaryl, C 0 –C 6 alkoxyaryl, C 0 –C 6 aminoaryl, C 0 –C 6 aminoalkylaryl, C 0 –C 6 heterocyclyl, C 0 –C 6 oxyheterocyclyl, C 0 –C 6 alkoxyheterocyclyl, C 0 –C 6 aminoheterocyclyl and C 0 –C 6 aminoalkylheterocyclyl; wherein any above C 1 –C 6 groups and amino groups can be optionally unsubstituted, mono-substituted or possibly disubstituted by lower alkyl; R 1 and R 2 are combined together as a fused spiro ring G comprising C, N, O or S, wherein ring G is selected from cycloalkyl, cycloalkenyl, aryl and heterocyclyl, which can be saturated or partially saturated and unsubstituted mono or polysubstituted; V is C, N or SO 2 ; W and W′ are independently of each other hydrogen, halogen or lower alkyl; or together with the carbon atom to form a cycloalkyl, a cycloalkenyl, or a heterocyclyl ring; n is an integer from 0 to 6; R 3 is a heterocyclyl or an aryl; R 4 is H or a lower alkyl; R 5 is H, halogen or lower alkyl; or of a N-oxide or a possible tautomer thereof; or a pharmaceutically acceptable salt thereof.