Patent ID: 7658886

Claim:
An assembled multiwell filtration device comprising: a multiwell filtration plate having a top surface, a bottom surface and two or more filtration plate wells located between the multiwell filtration plate top and bottom surfaces, each filtration plate well having an open top, one or more sidewalls, a bottom surface, a bottom outlet, and an inner bore formed from the one or more sidewalls, a plurality of first liquid permeable filter materials, wherein each of the first liquid permeable filter materials is permanently sealed to the bottom surface of a different filtration plate well, a plurality of inserts, each insert located within the inner bore of a different filtration plate well, between the multiwell filtration plate top and bottom surfaces, positioned adjacent to and in contact with the first liquid permeable filter material each insert having an upper surface, a lower surface, and a through bore having a height substantially the same as the depth of the filtration plate well inner bore, an open top and open bottom, wherein each insert through bore contains one or more of a second liquid permeable material including chromatography media, macroporous structures, frits, sintered glass, sintered plastic, cast in place filters, particle filled filters, nonwoven filters, microporous filters, a sample reservoir, a valve, and combinations thereof, an extension plate located above the multiwell filtration plate sealed to the top surface of the multiwell filtration plate and the upper surface of the inserts, the extension plate includes a series of two or more extension plate wells having an open top and an open bottom, equal in number, corresponding in position, and located above the two or more wells of the multiwell filtration plates and the plurality of inserts.