Patent ID: 8486426

Claim:
A method of treating a ungual condition comprising, a) applying to an ungual structure a composition comprising: a hydrophilic polymer matrix, wherein the hydrophilic polymer matrix includes a cross-linked polyacrylamide; at least one active agent, wherein the at least one active agent comprises a citric acid present at a concentration of from about 0.1% w/w to about 16% w/w; at least one humectant, wherein the humectant is present at a concentration of from about 15% to about 25w/w, further wherein in humectant includes glycerol; a moisture management system, wherein the moisture management system includes a non-gellable polysaccharide, wherein the non-gellable polysaccharide comprises guar gum, lucerne, fenugreek, honey locust bean gum, white clover bean gum, or carob locust bean gum; a moisture content ranging from 0.1% to 50% to create a diffusion gradient from the composition to the ungual structure, wherein the hydrophilic polymer matrix directly contacts the ungual structure, wherein moisture and the at least one active agent are transferred by the diffusion gradient from the hydrophilic polymer matrix composition to the ungual structure; and an open pattern adhesive, wherein the open pattern adhesive comprises a polvsiloxane, a polyisobutylene, a polyacrylate, an acrylic acid-acrylate copolymer, a polyisobutene, a polybutadiene, a polystyrene-isoprene copolymer, a polystyrene-butadiene copolymer, a neoprene, a polyacrylic acid, a polymethacrylic acid, or a blend of a hydrophilic cellulose derivative with a polyethylene glycol; and b) maintaining the composition at the ungual structure site for a sufficient amount of time so that an effective amount of the active agent is delivered.