Patent ID: 8513229

Claim:
A compound of Formula (I) wherein: X is NH 2 , F, H, SH, S(O)CH 3 , SCH 3 , SO 2 CH 3 , or OH; R 1 is phenyl optionally substituted with one or two substituents, one of which is selected from the group consisting of: OC (1-4) alkyl, SC (1-4) alkyl, SOC (1-4) alkyl, SO 2 C (1-4) alkyl, —OSO 2 NH 2 , —SO 2 NHC (1-4) alkyl, —OSO 2 NH 2 , —SO 2 NH 2 , N(C (1-4) alkyl) 2 , NH 2 , NHC (1-4) alkyl, NHSO 2 C (1-4) alkyl, N(SO 2 CH 3 ) 2 , OH, OC (1-4) alkylCO 2 C (1-4) alkyl, OC (1-4) alkylCO 2 H, OCH 2 CH 2 N(C (1-4) alkyl) 2 , F, Cl, CH 2 CN, CN, C (1-4) alkyl, NHCO 2 H, NHCO 2 C (1-4) alkyl, NHCOC (1-4) alkyl, —C≡CH, CONH 2 , NHCONH 2 , NHCONHC (1-4) alkyl, CONHC (1-4) alkyl, CH 2 CONHC (1-4) alkyl, C (1-4) alkylCONH 2 , C (1-4) alkylCO 2 C (1-4) alkyl, C (1-4) alkylCO 2 H, CO 2 H, CH 2 C(NH)NH 2 , CO 2 C (1-4) alkyl, CF 3 , OCHF 2 , CHF 2 , OCF 3 , OCH 2 CF 3 , cycloalkyl, heterocyclyl, phenoxy, phenyl, CH 2 -phenyl, CH 2 heteroaryl, and heteroaryl; and the second substituent, if present, is selected from the group consisting of F, C (2-4) alkyl and OCH 3 , or said phenyl may be substituted on two adjacent carbon atoms to form a fused bicyclic system, selected from the group consisting of benzothiazolyl, benzooxazolyl, benzofuranyl, indolyl, quinolinyl, isoquinolinyl, benzo[b]thiophenyl, 3H-benzothiazol-2-onyl, 3H-benzooxazol-2-onyl, 1,3-dihydro-benzoimidazol-2-onyl, 1-methyl-1H-benzoimidazolyl, benzo[1,3]dioxolyl, 2,3-dihydro-benzofuranyl, 2,3-dihydro-benzo[1,4]dioxinyl, wherein said 3H-benzooxazol-2-onyl, 1,3-dihydro-benzoimidazol-2-onyl, and 1-methyl-1H-benzoimidazolyl, are optionally substituted on any nitrogen atom with C (1-4) alkyl; R 2 is H, C (1-4) alkyl, NH 2 , NO 2 , NHCH 2 CH 2 OH, N(C (1-4) alkyl) 2 , N(SO 2 CH 3 ) 2 , NHCONHC (1-4) alkyl, CN, F, Cl, Br, CF 3 , cycloalkyl, heterocyclyl, OCF 3 , OCF 2 H, CF 2 H, or OC (1-4) alkyl; R 3 is F, Cl, CF 3 , or OC (1-4) alkyl; alternatively, R 2 and R 3 may be taken together with their attached phenyl to form a benzo[1,3]dioxolyl, 2,3-dihydro-benzofuranyl, or 2,3-dihydro-benzo[1,4]dioxinyl group; R 4 is H, OC (1-4) alkyl, or F; and a hydrate, tautomer or pharmaceutically acceptable salt thereof.