Patent ID: 7635697

Claim:
A compound of Formula 1.0: and the pharmaceutically acceptable salts thereof, wherein: the moiety is bound to the 2- or 3-position of Ring IV (wherein the R 5 , R 6 , and/or R 7 substituents are bound to the remaining 2-, 3-, 5-, and 6-positions of Ring IV), and wherein the moiety (1) is selected from the group of: (2) is selected from the group consisting of: a is N, and b, c and d are CR 1 ; each R 1 is independently selected from the group consisting of: H, halo, —CF 3 , —OR 20 , —COR 20 , —SR 20 , —S(O) t R 21 (wherein t is 0, 1 or 2), —N(R 20 )(R 21 ), —NO 2 , —OC(O)R 20 , —CO 2 R 20 , —OCO 2 R 21 , —CN, —NR 20 COOR 21 , —SR 20 C(O)OR 21 , —SR 21 N(R 75 ) 2 (provided that R 21 in —SR 21 N(R 75 ) 2 is not —CH 2 —), alkynyl, alkenyl and alkyl, wherein said alkyl or alkenyl group is optionally substituted with one or more substitutents selected from the group consisting of: halo, —OR 20 or —CO 2 R 20 , and wherein each R 75 is independently selected from H or —C(O)OR 21 ; R 3 and R 4 are each independently selected from the group consisting of H and halo; R 5 , R 6 , and R 7 are each H; t is 0, 1 or 2; each dotted line represents an optional bond; X represents N and the optional bond to carbon atom 11 is absent; the optional bond between carbon atoms 5 and 6 is absent, and the optional bond from carbon atom 5 to A is present, and the optional bond form carbon atom 6 to B is present, and A and B are each independently selected from the group consisting of: ═O, ═NOR 20 , —O—(CH 2 ) p —O—, the pair H and H, the pair —OR 21 and —OR 21 , the pair H and halo, the pair halo and halo, the pair alkyl and H, the pair alkyl and alkyl, the pair —H and —OC(O)R 20 , the pair H and —OR 20 , and the pair aryl and H; p is 2, 3 or 4; R 8 is selected from the group consisting of: R 11 is selected from the group consisting of: H, benyl, 3-phenylpropyl and n-butyl; R 16 is R 17 is methyl; R 20 represents H, alkyl aryl, or aralkyl; R 21 represents H, alkyl, aryl, or aralkyl; and n is 1 or 2.