Patent ID: 7919673

Claim:
A transgenic pig whose genome comprises a recombinant nucleic acid encoding a dominant-negative human glucose-dependent insulinotropic polypeptide receptor (GIPR dn ) operably linked to an insulin promoter that results in expression of the dominant-negative human glucose-dependent insulinotropic polypeptide receptor (GIPR dn ), wherein said pig expresses the dominant-negative human glucose-dependent insulinotropic polypeptide receptor (GIPR dn ), and wherein said pig exhibits, as a result of the expression of said receptor, at least one of: a) an elevated glucose level following an oral glucose load; b) reduced or delayed insulin secretion; c) reduced oral glucose tolerance; d) reduced pancreatic islet and β-cell mass; and e) impaired glucose-dependent insulinotropic polypeptide (GIP) function.