Patent ID: 8039670

Claim:
A compound of formula I, in which R 1 represents a hydrophobic moiety adapted to occupy the C′ channel of human CD1d, R 2 represents a hydrophobic moiety adapted to occupy the A′ channel of human CD1d, such that R 1 fills at least 30% of the occupied volume of the C′ channel compared to the volume occupied by the terminal nC 14 H 29 of the sphingosine chain of α-galactosylceramide when bound to human CD1d and R 2 fills at least 30% of the occupied volume of the A′ channel compared to the volume occupied by the terminal nC 25 H 51 of the acyl chain of α-galactosylceramide when bound to human CD1d, R 3 represents hydrogen or OH, R a and R b each represent hydrogen and in addition, when R 3 represents hydrogen, R a and R b together may form a single bond, X represents —CHA(CHOH) n Y or —P(═O)(O − )OCH 2 (CHOH) m Y, in which Y represents CHB 1 B 2 , n represents an integer from 1 to 4, m represents 0 or 1, A represents hydrogen, one of B 1 and B 2 represents H, OH or phenyl, and the other represents hydrogen or one of B 1 and B 2 represents hydroxyl and the other represents phenyl, in addition, when n represents 4, then A together with one of B 1 and B 2 together forms a single bond and the other of B 1 and B 2 represents H, OH or OSO 3 H and pharmaceutically acceptable salts thereof.