Patent ID: 7531511

Claim:
A method for inducing angiogenesis in a heart of a patient, comprising injecting an effective amount of an angiogenic agent directly into the myocardium of said patient in one or more areas in need of angiogenesis, said effective amount of angiogenic agent being from about 5 ng to about 1,350 ng of said angiogenic agent, wherein said angiogenic agent is a fibroblast growth factor-2 (FGF-2), or an angiogenically active fragment or mutein thereof, wherein said fragment comprises at least that portion of the amino acid sequence for said FGF-2 that corresponds to residues 30-110 of the FGF-2 sequence set forth in SEQ ID NO:2 or SEQ ID NO:6, and wherein said angiogenically active mutein has at least 90% amino acid sequence identity to said FGF-2.