Patent ID: 7524857

Claim:
A method for treating a disease caused or exacerbated by the proliferation of tumor cells which comprises administering to a patient having said disease and in need of such treatment an effective amount of at least one compound of formula: in which: R 1 represents a hydrogen atom or a methyl or ethyl group; R 2 represents a methyl or ethyl group; or R 1 and R 2 together form a (CH 2 ) 3 group; r 3 represents either a phenyl group optionally substituted with a halogen atom or a methyl or methoxy group, or a thienyl group; R 4 represents a hydrogen or chlorine atom or a methyl or methoxy group; or a pharmaceutically acceptable salt, hydrate or solvate thereof; in combination with one or more anticancer active principle(s) selected from alkylating agents, alkyl sulfonates, dacarbazine, procarbazine, nitrogen mustards, cyclophosphamide, ifosfamide, nitrosoureas, antineoplastic alkaloids, taxanes, antineoplastic antibiotics, intercalating agents, antineoplastic antimetabolites, folate antagonists, methotrexate, mercaptopurine, 6-thioguanine, aromatase inhibitors, capecitabine, fluorouracil, gemcitabine, cytarabine, cytosine arabinoside, brequinar, tamoxifen, kinase inhibitors, imatinib; growth factor inhibitors, antiinflammatory agents which can be used in the treatment of cancer, anti-topoisomerases, antracyclines, anticancer metallic complexes, platinum complexes, alpha-interferon, triphenylthio-phosphoramide, altretamine; anti-angiogenic agents, and immunotherapy adjuvants; wherein said disease is selected from the group consisting of breast cancer; lung cancer; cancer of the small intestine; cancer of the colon; cancer of the rectum; cancer of the respiratory pathways; cancer of the oropharynx; cancer of the hypopharynx; cancer of the esophagus; liver cancer; stomach cancer; cancer of the bile ducts; cancer of the bile vesicle; cancer of the pancreas; cancers of the urinary pathways; cancer of the bladder; cancers of the female genital tract; cancers of the male genital tract; cancers of the endocrine glands; skin cancers; tumors of the brain, tumors of the nerves, tumors of the eyes, tumors of the meninges; and tumors arising from hematopoietic malignant tumors.