Patent ID: 7279494

Claim:
A compound of formula I: or a pharmaceutically acceptable salts thereof; wherein Y is —SO m —, —O—, or —N(R 8 )—; Z is C(═Q)R 1 , —NHC(═Q)R 1 , —C(═Q)NHR 1 , —NHC(═NCN)R 1 , —NHC(═NNO 2 )R 1 , —SO 2 R 1 , or —NH 2 ; Q is oxygen or sulfur atom; R 1 —H, OH, —NH 2 , —NHC 1-4 alkyl, —C 1-4 alkyl, —C 2-4 alkenyl, —(CH 2 ) p C(═O)C 1-4 alkyl, —OC 1-4 alkyl, —SC 1-4 alkyl, —(CH 2 ) p C 3-6 cycloalkyl, —CH═CH-aryl, or CH 2 C(═O)-aryl; R 2 and R 3 are independently —H, or —F; R 4 and R 5 are independently —H, —Cl, —F, —CH 3 , —NH 2 , or —OH; R 6 and R 7 are independently —H, or —C 1-4 alkyl; R 8 independently —H, —OH, —CN, —NR 9 R 10 , —C 1-4 alkyl, —C 3-6 cycloalkyl, —C 1-4 heteroalkyl, -aryl, —C 1-4 alkylNR 9 R 10 , —(CH 2 ) p C(═O)C 1-4 alkyl, —(CH 2 ) p C(═O)C 3-6 cycloalkyl, —(CH 2 ) p C(═O)C 1-4 heteroalkyl, —C(═O)H, —(CH 2 ) p C(═O)OR 9 , —C(═O)(CH 2 ) p OR 9 , —(CH 2 ) p C(═O)C 1-4 alkylOR 9 , —(CH 2 ) p C(═O)(CH 2 ) p NR 9 R 10 , —(CH 2 ) p C(═O)NR 9 OR 10 , —(CH 2 ) p CH(═NOC 1-4 alkyl), —(CH 2 ) p C(═NOC 1-4 alkyl)C 1-4 alkyl, —(CH 2 ) p —SO 2 —C 1-4 alkyl, —(CH 2 ) p —SO 2 —NR 9 R 10 , CONHR 9 , or —C(═R 11 )(NR 12 R 12 ); each R 9 and R 10 are independently —H, —C 1-4 alkyl, —C 3-6 cycloalkyl, -aryl, —C(═O)C 1-4 alkyl, —C(═O)NHC 1-4 alkyl, —C(═O)aryl, —SO 2 C 1-4 alkyl, or —SO 2 NH 2 ; R 11 is ═NH, ═NCN, or CHNO 2 ; each R 12 is independently H, or C 1-3 alkyl; each m is independently an integer equal to 0, 1, or 2; each n is independently an integer equal to 0, or 1; each p is an integer equal to 0, 1 or 2; and at each occurrence, C 1-4 alkyl, or C 3-6 cycloalkyl is optionally substituted by one to three halo, hydroxyl, —CN, OC 1-2 alkyl or aryl.