Patent ID: 8153606

Claim:
A method of increasing function and/or expression of an apolipoprotein (ApoA1) polynucleotide in patient cells or tissues to treat a disease or disorder in said patient comprising: contacting said patient cells or tissues with at least one antisense nucleotide 5 to 30 nucleotides in length that is specific for and is targeted to a 5 to 30 nucleotide region within a non-coding and/or coding sequence of a natural antisense transcript of the apolipoprotein (ApoA1) polynucleotide; thereby increasing function and/or expression of the apolipoprotein (ApoA1) polynucleotide in said patient cells or tissues and wherein the disease or disorder is selected from the group consisting of a cardiovascular disorder, a cholesterol disorder, diabetes, heart disease, arthritis, inflammation, a neurological disease or disorder, an autoimmune disease or disorder and obesity.