Patent ID: 7973024

Claim:
A method for treating diseases which benefit from an inhibition of the catabolism of 1α,25-dihydroxy vitamin D 3 , or analogs thereof, said disease selected from the group consisting of breast cancer, lung cancer, prostate cancer, colon cancer, colorectal cancer, kidney cancer, head and neck cancer, pancreatic cancer, Kaposi's sarcoma, leukemia, psoriasis, hyperparathyroidism, secondary hyperparathyroidism and osteoporosis, comprising administering to a cell or animal in need thereof, an effective amount of a compound selected from a compound of Formula I, and pharmaceutically acceptable salts and prodrugs thereof: wherein R 1 is selected from the group consisting of OH, OC 1-4 alkyl, and halo; R 2 is selected from the group consisting of H, OH, OC 1-4 alkyl, and halo; each R 3 are either both H or together form ═CH 2 ; R 4 is C 1-4 alkyl; represents a single or a double bond; each R 5 can be the same or different and is selected from the group consisting of hydrogen, halo and C 1-4 alkyl or each R 5 can be taken together to form a C 3-6 cycloalkyl ring; R 6 is selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, aryl and heteroaryl, wherein each of C 1-6 alkyl, C 3-6 cycloalkyl, aryl and heteroaryl are either unsubstituted or substituted with 1-5 substituents independently selected from the group consisting of C 1-4 alkyl, OC 1-4 alkyl, CF 3 , NO 2 and halo; R 7 is selected from the group consisting of H, C 1-6 alkyl and C(O)R 8 ; and R 8 is selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, aryl-C 1-4 alkyl, aryl and heteroaryl, wherein each of C 1-6 alkyl, C 3-6 cycloalkyl, aryl and heteroaryl are either unsubstituted or substituted with 1-5 substituents independently selected from the group consisting of C 1-4 alkyl, OC 1-4 alkyl, CF 3 , NO 2 and halo, provided that when there is a double bond between C22 and C23, there is only one R 5 group attached to C23 and R 5 is selected from the group consisting of hydrogen, halo and C 1-4 alkyl, wherein the prodrug is a phenyl ester, aliphatic (C 8 -C 24 ) ester, acyloxymethyl ester, carbamate or amino acid ester formed from an available hydroxy, thiol, amino or carboxy group of a compound of Formula I.