Patent ID: 7417169

Claim:
A compound represented by general formula (I): a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R 1 is a hydrogen atom or a lower alkyl group; each of R 2 and R 3 is independently a hydrogen atom or a lower alkyl group; each of R 4 , R 5 and R 6 is independently a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R 7 is a hydrogen atom or a lower alkyl group; R 8 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, an aryloxy group, an aralkyloxy group, a heteroaryl group, a hydroxy-lower alkyl group, a hydroxy group, a di(lower alkyl)amino group, a cyclic amino group, a di(lower alkyl)amino-lower alkyl group, a lower acyl group, a lower alkylsulfanyl group, a lower alkylsulfonyl group, a carboxy group, a lower alkoxycarbonyl group or an aralkyloxycarbonyl group, or R 7 and R 8 are bonded together to form —OCH 2 O— or —CH═CH—CH═CH—; R 9 is a hydrogen atom, a halogen atom, a lower alkyl group, a halo-lower alkyl group, a hydroxy-lower alkyl group, a hydroxy group, a lower alkoxy group, a cyano group, a lower alkylsulfonyl group, a lower alkylsulfonylamino group, —COR 10 , -A 1 -COR 10 , or —O-A 2 -COR 10 ; R 10 is a hydroxy group, a lower alkoxy group or —NR 11 R 12 , each of R 11 and R 12 is independently a hydrogen atom, a lower alkyl group, a carboxy-lower alkyl group or a lower alkoxycarbonyl-lower alkyl group, or R 11 and R 12 , together with the nitrogen atom to which they are bonded, form a cyclic amine; A 1 is a lower alkylene group or a lower alkenylene group; A 2 is a lower alkylene group; Ar is a group represented by a formula: or a heteroaryl group; each of R 13 and R 14 is independently a hydrogen atom, a halogen atom, a lower alkyl group, a halo-lower alkyl group, a lower alkoxy group, a hydroxy group, a lower alkylsulfonylamino group or a lower acylamino group, or when R 13 and R 14 are adjacent each other, then R 13 and R 14 are bonded together to form a group represented by —NH—C(O)—NH—, provided that when one of R 13 and R 14 is a hydrogen atom, then the other is not a hydroxy group; and A is a bond, —OCH 2 — or —SCH 2 —.