Patent ID: 7884068

Claim:
A method for augmenting hydrophilic properties and increasing half-life of at least one albumin protein of interest in serum and decreasing the immunogenicity of at least one albumin protein comprising administering to a patient in need thereof, a composition comprising a polyethylene glycol-albumin-based colloid composition having at least one protected thiol region wherein the composition comprises PEG-Alb Cys-34 having a large hydrodynamic radius with Cys-34 preserved as a thiol, wherein the polyethylene glycol-albumin based colloid composition, has a molecular excluded volume and a hydrodynamic radius sufficiently large to preclude the composition from leaking through a patient's capillaries and wherein the albumin is human albumin or bovine serum albumin; and wherein the polyethylene glycol-albumin based colloid composition has an average molecular weight of at least 128,000 daltons.