Patent ID: 7259175

Claim:
A compound of the Formula I: and pharmaceutically acceptable salts thereof, wherein: (a) R3 is hydrogen; (b) R4 is hydrogen; (c) R5 is selected from the group consisting of (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkenyl, aryl(C 0 -C 4 )alkyl, aryloxy(C 0 -C 4 )alkyl, arylthio(C 0 -C 4 )alkyl, wherein said aryl(C 0 -C 4 )alkyl, aryloxy(C 0 -C 4 )alkyl, and arylthio(C 0 -C 4 )alkyl are each independently optionally substituted with from one to three substituents each independently selected from R5′; (d) R5′ are each independently selected from the group consisting of halo, —(O)—(C 1 -C 5 )alkylCOOH, C 1 -C 5 alkyl, C 1 -C 5 alkylCOOH, and CF 3 ; (e) R6 is selected from the group consisting of, optionally substituted pyridinyl, optionally substituted pyrimidinyl, and optionally substituted pyrazinyl wherein said substituted pyridinyl, pyrimidinyl, and pyrazinyl are substituted with from one to three substituents independently selected from R6′; (f) R6′ is independently selected from the group consisting of CF 3 , C 1 -C 4 alkyl, halo, hydroxy(C 1 -C 3 )alkyl, C 1 -C 3 alkoxy, and —C(O)CH 3 ; (g) R7 and R8 are each independently selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, and trifluoromethyl; (h) R9 and R10 are each independently selected from the group consisting of hydrogen, (C 1 -C 4 ) alkyl, (C 1 -C 3 ) alkenyl, halo, and (C 1 -C 4 ) alkoxy; (i) Q is selected from the group consisting of O, C, and a single bond; (j) W is selected from the group consisting of O, S, and SO 2 ; (k) X is C m H 2m ; (l) m is selected from the group consisting of 0, 1 and 2; (m) Y and Z are each independently selected from the group consisting of N, S, and O, with the proviso that at least one of Y and Z is selected from the group consisting of S and O; (n) A is COOH; (o) n is 0, 1, 2 or 3; (p) R19 is selected from the group consisting of hydrogen, C1-C4alkyl and arylmethyl, wherein said alky and arylmethyl are each optionally substituted with from one to three substituents each independently selected from R19′; and (q) R19′ are each independently selected from the group consisting of halo, —(O)—(C 1 -C 5 )alkylCOOH, C 1 -C 5 alkyl, and CF 3 ; with the proviso that when R3 and R4 are each hydrogen, and at least one selected from the group consisting of R7 and R8 is CF 3 , then R5 is selected from the group consisting of (C 3 -C 6 ) alkyl, (C 1 -C 6 ) alkenyl, substituted aryl(C 0 -C 4 )alkyl, substituted aryloxy(C 0 -C 4 )alkyl, substituted arylthio(C 0 -C 4 )alkyl, unsubstituted aryl(C 0 -C 4 )alkyl, unsubstituted aryloxy(C 0 -C 4 )alkyl, and unsubstituted arylthio(C 0 -C 4 )alkyl.