Patent ID: 7405204

Claim:
A compound of formula I: wherein: Y is O or CH 2 ; X is selected from halo and O—W 2 ; each of W, W 1 and W 2 is independently selected from the group consisting of hydrogen, C 1 -C 4 alkyl, acyl, oxyacyl, phosphonate, phosphate esters, phosphate, phosphonamidate, phosphorodiamidate, phosphoramidate monoester, cyclic phosphoramidate, cyclic phosphorodiamidate, and phosphoramidate diester, provided that when X is —O—W 2 , one of W, W 1 and W 2 is C 1 -C 4 alkyl; R 3 is selected from the group consisting of hydrogen, OH, acyl, C 1 -C 4 alkyl, and C 1 -C 4 alkoxy; T is selected from the group consisting of: a) —C≡C—R, where R is selected from the group consisting of: i) hydrogen; ii) tri(C 1 -C 4 )alkylsilyl, —C(O)NR 1 R 2 , alkoxyalkyl, heteroaryl, substituted heteroaryl, phenyl, and substituted phenyl; where R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, amino, substituted amino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic provided that only one of R 1 and R 2 is amino or substituted amino, and further wherein R 1 and R 2 , together with the nitrogen atom pendant thereto, form a heterocyclic or substituted heterocyclic; and iii) —C(O)OR 14 , where R 14 is hydrogen, alkyl or substituted alkyl; b) —CH═CH-Q 2 , where Q 2 is selected from hydrogen or cis-alkoxy; c) —C(O)H; d) —CH═NNHR 15 , where R 15 is hydrogen or C 1 -C 4 alkyl; e) —CH═N(OR 15 ), where R 15 is as defined above; f) —CH(OR 16 ) 2 , where R 16 is C 3 -C 6 alkyl; g) —B(OR 15 ) 2 , where R 15 is as defined above; and h) —NO 2 ; or pharmaceutically acceptable salts or partial salts thereof; provided that when R 3 is hydrogen, OH, or C 1 -C 3 alkoxy, then X is halo or —O(C 1 -C 4 alkyl).