Patent ID: 8101573

Claim:
An isolated conopeptide selected from the group consisting of: (a) Gly-Cys-Cys-Ser-Asn-Pro-Val-Cys-Ala-Leu-Glu-His-Ser-Asn-Ala-Cys (SEQ ID NO: 13); (b) a derivative of (a) having α6-containing nicotinic acetylcholine receptor binding activity, wherein the derivative is a peptide in which the Pro residue is substituted with hydroxy-Pro or O-glycosylated hydroxy-Pro; one or both of the Ser residues is or are substituted with O-glycosylated Ser; one or both of the Asn residues is or are substituted with N-glycosylated Asn; the Cys residues are in D or L configuration; or one or more of the Cys residues is or are substituted with homocysteine in the D or L configuration; and (c) a physiologically acceptable salt of (a) or (b).