Patent ID: 6887995

Claim:
A novel process for preparing a compound of formula I or a salt thereof, which comprises reacting a N-aryl â€”O-alkylcarbamate of formula II or a salt thereof, with a compound of formula III or a salt thereof, in the presence of a lithium cation, a base and a nucleophile, wherein X and Y are independently H or F; W1 is Cl, Br, or â€”OS(O) 2 â€”R; W2 is H or â€”C(O)â€”R 1 ; R is aryl or alkyl, the alkyl optionally being substituted by one or more F, Cl, Br, or I; R 1 is CH 3 , optionally substituted by one to three fluorine or chlorine atoms; R 2 is cycloalkyl, phenyl, â€”CH 2 -phenyl, C 2-6 alkenyl, or C 1-12 alkyl optionally substituted by one to three of F, Br, Cl, â€”Oâ€”C 1-6 alkyl, and NR 2a R 2b ; Each R 2a and R 2B is independently H or C 1-4 alkyl; Q is structure ii: Z 2 is S, SO, SO 2 , O, or N(R); R 6 is a) H, b) C 1-6 alkyl, optionally substituted with one or more OH, CN, or halo, c) â€”(CH 2 ) h -aryl, d) â€”COR 11 , e) â€”COOR 12 , f) â€”COâ€”CH 2 ) h â€”COR 11 , g) â€”SO 2 â€”C 1-6 alkyl, h) â€”SO 2 â€”(CH 2 ) h -aryl, or i) â€”(CO) i -het; R 12 is a) H, b) C 1-6 alkyl, optionally substituted with one or more OH, CN, or halo, c) â€”(CH 2 ) h -aryl, or d) â€”(CH 2 ) h â€”OR 13 ; R 12 is a) C 1-6 alkyl, optionally substituted with one or more OH, CN, or halo, b) â€”(CH 2 ) h -aryl, or c) â€”(CH 2 ) h â€”OR 13 ; R 13 is a) H, b) C 1-6 alkyl, c) â€”(CH 2 ) h -aryl, or d) â€”CO(C 1-6 alkyl); aryl is phenyl, pyridyl or napthyl; at each occurance, aryl or phenyl may be optionally substituted with one or more F, Cl, Br, I, CN, OH, SH, C 1-6 alkyl, OC 1-6 alkyl, or SC 1-6 alkyl, or OC(O)CH 3 ; het is 5- to 10-membered heterocyclic rings having one or more oxygen, nitrogen, and sulfur atoms; his 1,2,3, or 4; i is 0 or 1; and m is 0 or 1.