Patent ID: 8852557

Claim:
A method for producing a pharmaceutical aerosol for the delivery of an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus, said aerosol comprising a dispersed liquid phase and a continuous gas phase, said method comprising: (a) providing an aerosol generator adapted for emitting an aerosol (i) at an effective flow rate of less than 5 liters/min of the gas phase, and (ii) at a rate of at least 0.3 ml of dispersed liquid phase per minute; (b) providing a means for effecting a pressure pulsation of an aerosol having a frequency in the range from 10 to 90 Hz; (c) providing a liquid composition comprising said active compound, wherein a unit dose of the active compound is comprised in a volume of less than 5 ml of said liquid composition, and (d) operating said aerosol generator for nebulising said liquid composition into an aerosol at an effective flow rate of less than 5 liters/min of the gas phase and operating said means to effect a pressure pulsation of the aerosol at a frequency in the range from 10 to 90 Hz; wherein the effective flow rate is the flow rate of the aerosol as it enters the respiratory system of the patient.