Patent ID: 7994119

Claim:
A method for controlling an NPY mediated physiological response in a subject comprising administering to said subject a compound having the formula: R8-linker[A1-A2-A3] n -W wherein: R8 is H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-(SEQ. ID. NO.1), H-[X(Y)] n -where X is Ser, Thr, or Tyr, Y is β-D-Glc or β-D-Gal, and n is 1, 2, or 3, (SEQ. ID. NO. 9), Ac-Arg-Tyr-Arg-Gly-Asp-Leu-Gly-Leu-Gly-Arg-Arg (SEQ. ID. NO. 10), or SEQ. ID. NO. 11); A1 is a D or L-amino acid selected from Cys, Leu, Dap, Trp, Gln, a tethered amino acid with an indole ring, Phe, Hyp, a Trp derivative; C α Me-Trp, C α Me-Gln, Des-amino-Trp, Pyr, Bth, Nal, Tcc, Asn, Nva, Abu, Ser, Tyr, Tic-OH, Phe, Tip, and Dip; Linker is a compound that forms a peptide bond with A1 and forms one of either a peptide or ester bond with R8; A2 is a D or L-amino acid selected from Gly, Cys, Trp, Arg, N-Me-Arg, C α Me-Arg, Orn, Cit, hArg(R)2 where R is selected from hydrogen, alkyl, aryl, aralkyl, or alkylaryl, Lys-ε-NH-R where R is selected from hydrogen, alkyl, aryl, aralkyl, or alkylaryl; A3 is a D or L-amino acid selected from Glu, Tyr, N-Me-Tyr, C α Me-Tyr, Tic-OH, Tic, Dip, Trp, Phe, des-carboxylic-Tyr, and Tyr-(R) where R is hydrogen or a lipophilic group; n=1, 2 or 3 W is —OH, —N-R3R4, or OR5 where R3, R4, and R5, independently, is H, C1-C12 alkyl, C6-C18 aryl, C1-C12 acyl, C7-C18 aralkyl, or C7-C18 alkaryl; or a pharmaceutically acceptable salt thereof; and each bond between two amino acids or amino acid derivatives, represented by a dash (“-”), can be either a peptide bond or a pseudopeptide bond; or a pharmaceutically acceptable salt thereof.