Patent ID: 7135593

Claim:
A crosslinked hydrogel, comprising a hydrophilic polymer; and a crosslinker selected from the group consisting of a compound of formula 1 and a compound of formula 2, wherein said compound of formula 1 is represented by: wherein X represents independently for each occurrence O or S; L represents independently for each occurrence —NH—O—Q, or —O—NH—Q; Q represents independently for each occurrence acryloyl, 2-alkylacryloyl, 3-alkylacryloyl, 2,3-dialkylacryloyl, 3,3-dialkylacryloyl, 2,3,3-trialkylacryloyl, acryloylO(CR 2 ) n C(O)—, 2-alkylacryloylO(CR 2 ) n C(O)—, 3-alkylacryloylO(CR 2 ) n C(O)—, 2,3-dialkylacryloylO(CR 2 ) n C(O)—, 3,3-dialkylacryloylO(CR 2 ) n C(O)—, 2,3,3-trialkylacryloylO(CR 2 ) n C(O)—, (diene)C(O)—, (vinyl)(CR 2 ) n C(O)—, or (vinyl)ArC(O)—; R represents independently for each occurrence H or alkyl; Z represents (CR 2 ) n ,(CR 2 ) n J(CR 2 ) m , or (CR 2 ) n Ar(CR 2 ) m ; Ar represents independently for each occurrence aryl or heteroaryl; J represents independently for each occurrence O, S, NR, cycloalkyl, heterocyclyl, (CH 2 CH 2 O) n , or (CH 2 CH 2 N(R)) n ; n represents independently for each occurrence an integer in the range 1–10; and m represents independently for each occurrence an integer in the range 0–10; and said compound of formula 2 is represented by: wherein X represents independently for each occurrence O or S; M represents independently for each occurrence —NH—O—Q, or —O—NH—Q; Q represents independently for each occurrence acryloyl, 2-alkylacryloyl, 3-alkylacryloyl, 2,3-dialkylacryloyl, 3,3-dialkylacryloyl, 2,3,3-trialkylacryloyl, acryloylO(CR 2 ) n C(O)—, 2-alkylacryloylO(CR 2 ) n C(O)—, 3-alkylacryloylO(CR 2 ) n C(O)—, 2,3-dialkylacryloylO(CR 2 ) n C(O)—, 3,3-dialkylacryloylO(CR 2 ) n C(O)—, 2,3,3-trialkylacryloylO(CR 2 ) n C(O)—, (diene)C(O)—, (vinyl)(CR 2 ) n C(O)—, or (vinyl)ArC(O)—; R represents independently for each occurrence H or alkyl; Z represents (CR 2 ) n , (CR 2 ) n J(CR 2 ) m , or (CR 2 ) n Ar(CR 2 ) m ; Ar represents independently for each occurrence aryl or heteroaryl; J represents independently for each occurrence O, S, NR, cycloalkyl, heterocyclyl, (CH 2 CH 2 O) n , or (CH 2 CH 2 N(R)) n ; G represents (CR (4−t) ), aryl, or heteroaryl; n represents independently for each occurrence an integer in the range 1–10; and t represents 3 or 4.