Patent ID: 7343247

Claim:
A computational method of classifying a population by drug responsiveness, comprising: (a) creating a multidimensional space of n dimensions, wherein n represents the number of different molecules being analyzed in a specimen from each individual in a population of individuals administered a drug and wherein said multidimensional space contains n axes, each of said axes relating to the expression level of a molecule of said n molecules, wherein n is 3 or more molecules and wherein said molecules are nucleic acids or polypeptides; (b) determining multidimensional coordinate points for each individual in said population, wherein each of said multidimensional coordinate points is representative of the expression levels of said n molecules in each of said individuals; (c) determining a drug response-associated reference expression region of a group of individuals in said population using said multidimensional coordinate points, thereby classifying said group of individuals into a drug response reference population; and (d) providing an output of said classification of said drug response reference population to a user.