Patent ID: 8563291

Claim:
A process for producing recombinant proteoliposomes which comprises steps (1) to (4): (1) preparing budded virus particles having membrane receptors on an envelope, of a recombinant baculovirus, (2) ultracentrifuging the prepared budded virus particles in a stepwise sucrose density gradient of 10%, 15%, 20%, 25% and 30% sucrose (w/v) to produce fractions, (3) collecting one or more fractions containing virus envelopes of the prepared budded virus particles having virus membrane receptors and not having nucleic acids, and (4) producing recombinant proteoliposomes by fusing of the virus envelopes collected in step (3) with liposomes at acidic pH, wherein membrane receptors of the recombinant proteoliposomes retain antigenicity.