Patent ID: 8101207

Claim:
A composition, comprising: a very low water-soluble drug; and a porous silicon material; wherein: the composition is produced by treating a mixture comprising the very low water-soluble drug and the porous silicon material with a supercritical or subcritical carbon dioxide fluid; the very low water-soluble drug has a solubility in water at 25° C. of less than 10 μg/mL prior to treatment; the porous silicon material comprises at least one member selected from the group consisting of light anhydrous silicic acid, hydrated silicon dioxide, silicon dioxide, and calcium silicate; the porous silicon material is not a porous silica material having all of the following: an average pore diameter of 1 to 20 nm; 60% or more of a volume of all of the pores of the porous silica material have a diameter falling within a range of ±40% of the average pore diameter; and an X-ray diffraction pattern including one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more; the porous silicon material has an average pore diameter of 1 to 500 nm; the porous silicon material has a specific surface area of 100 to 1,800 m 2 /g; and the composition is suitable for oral administration.