Patent ID: 7943643

Claim:
A compound having the Formula I: or a pharmaceutically acceptable salt thereof, wherein: Ar is Ar 3 , wherein Ar 3 is R 1 is C(O)R 10 ; R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, alkenyl, or alkynyl, halogen, hydroxy, cycloalkyl, cyano, amino, alkylamino, dialkylamino, alkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, and aralkylcarbonylamino; provided that the pyridyl ring is other than 2,6-disubstituted with regard to Ar and R 1 or any of R 2 -R 4 that is other than hydrogen; R 5 , R 6 , R 7 , and R 8 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido and alkylthiol; and R 10 is selected from the group consisting of alkyl, alkenyl, alkynyl, OR 11 , amino, alkylamino, dialkylamino, alkenylamino, dialkylaminoalkenyl, dialkylaminoalkylamino, dialkylaminoalkenylamino, alkylaminoalkenyl-amino, hydroxyaminoalkenylamino, cycloalkyl, heterocycloalkyl, cycloalkylalkylamino, heterocycloalkylamino, aryl, arylalkyl, arylalkenyl, arylalkynyl, and arylalkylamino, all of which are optionally substituted, wherein R 11 is selected from the group consisting of hydrogen, optionally substituted alkyl, and an alkali metal.