Patent ID: 7750161

Claim:
A compound of General Formula 2: wherein: Py represents pyridin-4-yl which is disubstituted in positions 2 and 6, whereby the substituent in position 2 is C 1-7 -alkyl or aryl-C 1-7 -alkyl; and the substituent in position 6 is methyl or ethyl; X represents R 1 —SO 2 NR 2 —; R 1 —CONR 2 —; aryl-R 8 —CONR 2 —; or R 1 —NR 3 CONR 2 —; Z represents hydrogen; n represents the number 1; R 1 represents aryl or aryl-C 1-7 -alkyl; R 2 represents hydrogen; C 1-7 -alkyl; 2-hydroxyethyl; aryl-C 1-7 -alkyl; or a saturated carbocyclic ring; R 3 represents hydrogen or C 1-7 -alkyl; R 8 represents a saturated carbocyclic ring; wherein aryl means a group selected from the group consisting of 2-furyl; 2-thienyl; phenyl; 2-methylphenyl; 3-methylphenyl; 4-methylphenyl; 2-biphenyl; 3-biphenyl; 4-biphenyl; 2-methoxyphenyl; 3-methoxyphenyl; 4-methoxyphenyl; 3,4-dimethoxyphenyl; 2,6-dimethoxyphenyl; 2,5-dimethoxyphenyl; 2-phenoxyphenyl; 3-phenoxyphenyl; 4-phenoxyphenyl; 2-cyanophenyl; 3-cyanophenyl; 4-cyanophenyl; 2-fluorophenyl; 3-fluorophenyl; 4-fluorophenyl; 2,4-difluorophenyl; 2,5-difluorophenyl, 2,6-difluorophenyl; 3,4-difluorophenyl; 2-chlorophenyl; 3-chlorophenyl; 4-chlorophenyl; 3,4-dichlorophenyl; 2-bromophenyl; 3-bromophenyl; 4-bromophenyl; 2-trifluoromethylphenyl; 3-trifluoromethylphenyl; 4-trifluoromethylphenyl; 3,5-bis-trifluoromethylphenyl; 4-trifluoromethoxyphenyl; 4-ethylphenyl; 4-n-propylphenyl; 2-iso-propylphenyl; 4-iso-propylphenyl; 4-tert-butylphenyl; 4-n-pentylphenyl; 4-bromo-2-ethylphenyl; 2-methanesulfonylphenyl; 3-methanesulfonylphenyl; 4-methanesulfonylphenyl; 4-acetamidophenyl; 4-hydroxyphenyl; 4-iso-propyloxyphenyl; 4-n-butoxyphenyl; 2-methoxy-4-methylphenyl; 4-methoxy-2,3,6-trimethylphenyl; 5-bromo-2-methoxy-phenyl; 2-pyridyl; 3-pyridyl; 4-pyridyl; 1-naphthyl; 2-naphthyl; 4-(pyrrol-1-yl)phenyl; 4-benzoylphenyl; 5-dimethylaminonaphth-1-yl; 5-chloro-3-methylthiophen-2-yl; 5-chloro-3-methyl-benzo[b]thiophen-2-yl; 3-(phenylsulfonyl)-thiophen-2-yl; 2-chloro-thien-5-yl; 2,5-dichloro-thien-3-yl; 4,5-dichlorothien-2-yl; 2-(2,2,2-trifluoroacetyl)-1-2,3,4-tetrahydroisoquinolin-7-yl; 4-(3-chloro-2-cyanophenyloxy)phenyl; 2-(5-benzamidomethyl)thiophenyl; 5-quinolyl; 6-quinolyl; 7-quinolyl; 8-quinolyl; (2-acetylamino-4-methyl)thiazol-5-yl; and 1-methylimidazol-4-yl; and aryl-C 1-7 -alkyl means 3-phenylpropyl, phenethyl, benzyl, or benzyl substituted in the phenyl ring with C 1-7 -alkyl, C 1-7 -alkyl-O—, trifluoromethyl or halogen; or pharmaceutically acceptable salts thereof.