Patent ID: 7402586

Claim:
A compound having Formula VII: or a pharmaceutically acceptable salt thereof; wherein: R 1 is alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, aralkyl, heterocycle or heterocycloalkyl, any of which may be optionally substituted; Z is NR 2 CO— or a covalent bond, where R 2 is hydrogen, alkyl, aralkyl, aryl, hydroxy(C 2-10 )alkyl, amino(C 2-10 )alkyl, monoalkylamino(C 2-10 )alkyl, dialkylamino(C 2-10 )alkyl or carboxyalkyl; Het is selected from the group consisting of where R 3 and R 5 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, trifluoromethyl, halogen, hydroxyalkyl, cyano, nitro, carboxamido, alkoxycarbonylmethyl, carboxymethyl, —CO 2 R x , —CH 2 OR x or —OR x , where R x , in each instance, is independently one of hydrogen, alkyl or cycloalkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations; R 6 is hydrogen, alkyl, aralkyl, aryl, cyano(C 2-10 )alkyl, hydroxy(C 2-10 )alkyl, alkoxy(C 2-10 )alkyl, mono- and di-alkylamino(C 2-10 )alkyl, or carboxyalkyl; R 7 is hydrogen, C 1-4 alkyl, or C 2-4 alkenyl; R 8 is hydrogen, alkyl, alkenyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylamino (C 2-10 )alkyl, dialkylamino(C 2-10 )alkyl or carboxyalkyl; R 12 , R 13 , R 14 and R 15 are independently hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl or carboxyalkyl; or R 12 and R 13 are taken together to form —(CH 2 ) y —, where y is 2 to 7, while R 14 and R 15 are defined as above; or R 14 and R 15 are taken together to form —(CH 2 ) q —, where q is 2 to 7, while R 12 and R 13 are defined as above; or R 12 and R 14 are taken together to form —(CH 2 ) r —, where r is 0 (a bond) or 1 to 7, while R 13 and R 15 are defined as above; X is oxygen or NR 9 , where R 9 is hydrogen, alkyl, cycloalkyl or aryl, wherein said alkyl, cycloalkyl or aryl can be optionally substituted with amino, monoalkylamino, dialkylamino, alkoxy, hydroxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, aryl, heteroaryl, acylamino, cyano or trifluoromethyl; R a , R b and R c are independently hydrogen, alkyl, hydroxy, alkoxy, aryloxy, aralkoxy, alkoxycarbonyloxy, cyano or —CO 2 R w , where R w is alkyl, cycloalkyl, phenyl, benzyl, where R d and R e are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl or phenyl, R f is hydrogen, C 1-6 alkyl, C 2-6 alkenyl or phenyl, R g is hydrogen, C 1-6 alkyl, C 2-6 alkenyl or phenyl, and R h is aralkyl or C 1-6 alkyl; n is from zero to 8; m is from zero to 6.