Patent ID: 8138198

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein X is N; Y is independently CH or CH 2 and when Y is CH then a substituent of CH is attached to the Y atom of the ring structure; n is 0 or 1 and when n is 0 than a direct bond is intended; R 1 is phenyl, or naphtalenyl; wherein each of said phenyl or naphtalenyl is optionally substituted with one or two substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyloxy, polyhaloC 1-6 alkyl, aryl, hydroxy, cyano, amino, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxymethyl, aminomethyl, C 1-6 alkylaminomethyl, C 1-6 alkylcarbonylaminomethyl, C 1-6 alkylsulfonylaminomethyl, aminosulfonyl, C 1-6 alkylaminosulfonyl or heterocyclyl; R 2 is —CH 2 —R 5 , trifluoromethyl, —C(═O)—R 6 , or —CH 2 —NR 7 R 8 ; wherein each R 5 is independently selected from hydrogen, hydroxy, C 1-6 alkyloxy, piperazinyl, N-methylpiperazinyl, morpholinyl, thiomorpholinyl, imidazolyl or triazolyl; each R 6 is independently selected from hydroxy, C 1-6 alkyloxy, amino or mono- or di(C 1-6 alkyl)amino, C 3-6 cycloalkylamino, piperazinyl, N-methylpiperazinyl, morpholinyl or thiomorpholinyl; each R 7 and R 8 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl, or mono-or di(C 1-4 alkyl)aminosulfonyl; R 3 is hydrogen, C 1-6 alkyl , cyanoC 1-4 alkyl, C 1-6 alkyloxycarbonyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-6 alkyl, arylC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl; R 4 is hydroxy.