Patent ID: 7041820

Claim:
A process for producing a (dioxolenon-4-yl)methyl ester derivative of formula (3) (where Q represents the fused heterocyclic group having a β-lactam ring of the following formulae: where r 1 and r 4 represent a 1-hydroxyethyl group or an optionally substituted benzoylamino group; r 2 , r 5, r 6 , r 7 and r 8 each independently represent hydrogen or a C 1-6 alkyl group that may be optionally substituted by G 1 ; a C 2-6 alkenyl group that may be optionally substituted by G 1 ; a C 2-6 alkynyl group that may be optionally substituted by G 1 ; a tetrahydrofuranyl and a heterocyclic group that may optionally be substituted by G 1 ; G 1 represents a nitro group; a cyano group; a halogen atom; a C 1-6 alkoxy group; a C 1-6 alkylthio group; a C 1-6 alkylsulfinyl group; a C 1-6 alkylsulfonyl group; a C 1-6 alkylamino group; a di-C 1-6 alkylamino group; a C 1-6 alkylcarbonyl group; a C 1-6 alkoxycarbonyl group; an optionally G 2 substituted phenylsulfinyl group; an optionally G 2 substituted phenylsulfonyl group; an optionally G 2 substituted phenylthio group; G 2 represents a halogen atom; a C 1-6 alkyl group; a C 1-6 haloalkyl group; or a C 1-6 haloalkoxy group; and R 1 and R 2 each independently represent a hydrogen atom, an optionally substituted C 1-6 alkyl group or an optionally substituted phenyl group, provided that R 1 and R 2 may combine to form an optionally substituted ring having 3–8 carbon atoms) by reacting a carboxylic acid derivative of formula (1) (where Q has the same meaning as defined above, M represents a hydrogen atom, an alkali metal, an alkaline earth metal or a transition metal, and n represents the atomic valency of M) with a 4-chloromethyldioxolenone compound of formula (2) (where R 1 and R 2 have the same meanings as defined above) in a solvent in the presence of both a phase transfer catalyst and a metal iodide.