Patent ID: 7786107

Claim:
A compound of formula I: a pharmaceutically acceptable salt thereof, wherein X 1 is —NR 3A —; X 2 is —CR′ 3B R′ 3C —; X 3 is —CR 4A R 4B —; X 4 is —CR′ 4A R′ 4B —; R 1 is hydrogen, optionally substituted C 1-12 aliphatic, optionally substituted cycloaliphatic, or optionally substituted heterocycloaliphatic; Each R 2 is independently —Z A R 5 , wherein each Z A is independently a bond or is an optionally substituted C 1-8 aliphatic chain wherein up to two carbon units of Z A are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR A —, —CONR A NR A —, —CO 2 —, —OCO—, —NR A CO 2 —, —O—, —NR A CONR A —, —OCONR A —, —NR A NR A , —NR A NR A CO—, —NR A CO—, —S—, —SO—, —SO 2 —, —NR A —, —SO 2 NR A —, —NR A SO 2 —, —P(O)(OR A )—, —P(O)(OR A )NR A — or —NR A SO 2 NR A —, Each R 5 is independently R A , halo, —OH, —NH 2 , —NO 2 , —CN, —CF 3 , or —OCF 3 , Each R A is independently hydrogen, optionally substituted C 1-6 aliphatic, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl; Each of R 3A , R′ 3B , and R′ 3C is independently —Z B R 6 , wherein each Z B is independently a bond or is an optionally substituted C 1-8 aliphatic chain wherein up to two carbon units of Z B are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR B —, —CONR B NR B —, —CO 2 —, —OCO—, —NR B CO 2 —, —O—, —NR B CONR B —, —OCONR B —, —NR B NR B , —NR B NR B CO—, —NR B CO—, —S—, —SO—, —SO 2 —, —NR B —, —SO 2 NR B —, —NR B SO 2 —, —P(O)(OR B )—, —P(O)(OR B )NR B — or —NR B SO 2 NR B —, Each R 6 is independently R B , halo, —OH, —NH 2 , —NO 2 , —CN, —CF 3 , or —OCF 3 , Each R B is independently hydrogen, optionally substituted C 1-6 aliphatic, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl, or R′ 3B and R′ 3C together with the carbon atom to which they are attached form a carbonyl group; Each of R 4A , R′ 4A , R 4B , and R′ 4B is independently —Z C R 7 , wherein each Z C is independently a bond or is an optionally substituted C 1-8 aliphatic chain wherein up to two carbon units of Z C are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR C —, —CONR C NR C —, —CO 2 —, —OCO—, —NR C CO 2 —, —O—, —NR C CONR C —, —OCONR C —, —NR C NR C , —NR C NR C CO—, —NR C CO—, —S—, —SO, —SO 2 —, —NR C —, —SO 2 NR C —, —NR C SO 2 —, —P(O)(OR C )—, —P(O)(OR C )NR C — or —NR C SO 2 NR C —, Each R 7 is independently R C , halo, —OH, —NH 2 , —NO 2 , —CN, —CF 3 , or —OCF 3 , Each R C is independently hydrogen, optionally substituted C 1-6 aliphatic, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl, or R 4A and R 4B together with the carbon atom to which they are attached form a carbonyl group; m is 1-3; n is 1-3; and q is 0-4.