Patent ID: 7173043

Claim:
A compound selected from the group consisting of compounds of formula (I) wherein U is O or a lone pair, Y is CR 1 , Z is S or S(O 2 ), V is â€”Câ‰¡Câ€”, and m is 0 to 7, n is 0 to 7, m+n is â‰¦7, Q is cycloalkyl, cycloalkyl-lower-alkyl, phenyl optionally substituted by 1 to 3 substituents independently selected from the group as defined for R 3 , or an alkyl, alkenyl or alkadienyl group optionally substituted by OH, A 1 is hydrogen, lower-alkenyl, or lower-alkyl optionally substituted with hydroxy, lower-alkoxy, or thio-lower-alkoxy, A 2 is cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkinyl, heteroaryl, or lower-alkyl optionally substituted with halogen, hydroxy, lower-alkoxy, or thio-lower-alkoxy, or A 1 and A 2 are bonded to each other to form a ring and -A 1 -A 2 - is lower-alkylene, or lower-alkenylene, optionally substituted by R 4 , in which one â€”CH 2 â€” group of -A 1 -A 2 - can optionally be replaced by a NR 5 , S, or O, or -A 1 -A 2 - is â€”CHâ•Nâ•CHâ•CHâ€” which can optionally be substituted by lower-alkyl, A 3 and A 4 independently from each other are hydrogen or lower-alkyl, or A 3 and A 4 are bonded to each other to form a ring together with the carbon atom to which they are attached and -A 3 -A 4 - is â€”(CH 2 ) 2-5 â€” which can optionally be mono- or multiply-substituted by lower-alkyl, X is hydrogen or one or more optional halogen and/or lower-alkyl substituents, R 1 is hydrogen or lower-alkyl, R 2 is hydrogen or lower-alkyl, R 3 is halogen, N(R 6 ,R 7 ), piperidyl, piperazinyl, piperazinyl-ethanone, morpholinyl, CONH 2 , CN, NO 2 , CF 3 , OH, lower-alkoxy, thio-lower-alkoxy, or is lower-alkyl, lower-alkenyl, or lower-alkinyl, optionally substituted with OH, SH or N(R 8 ,R 9 ), R 4 is hydroxy, lower-alkyl, lower-alkoxy, or thio-lower-alkoxy, R 5 is hydrogen, lower-alkyl, or lower-alkyl-carbonyl, R 6 and R 7 independently from each other are selected from the group consisting of hydrogen, lower-alkyl, phenyl and benzyl, R 8 and R 9 independently from each other are selected from the group consisting of hydrogen and lower-alkyl; pharmaceutically acceptable salts of compounds of formula (I); and pharmaceutically acceptable esters of compounds of formula (I).