Patent ID: 8563741

Claim:
A compound represented by formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein Cy is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl and substituted cycloalkyl; W is selected from hydrogen, halogen, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl and substituted cycloalkyl; Z is O, S, S(O), SO 2 , SO 2 NH, NR 8 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C(O) or C(O)NH; Y is N; A is CR 8 , where R 8 is hydrogen, acyl, aliphatic or substituted aliphatic; X is S; B is a linker or a direct bond; C is selected from: where W 1 is O or S; Y 1 is absent, N, or CH; Z 1 is N; R 7 and R 9 are independently hydrogen, OR′, aliphatic or substituted aliphatic, wherein R′ is hydrogen, aliphatic, substituted aliphatic or acyl; provided that if R 7 and R 9 are both present, one of R 7 or R 9 must be OR′ and if Y is absent, R 9 must be OR′; and R 8 is hydrogen, acyl, aliphatic or substituted aliphatic; where W 1 is O or S; J is O, NH or NCH 3 ; and R 10 is hydrogen or lower alkyl; where W 1 is O or S; Y 2 and Z 2 are independently N, C or CH; and where Z 1 , Y 1 , and W 1 are as previously defined; R 11 and R 12 are independently selected from hydrogen or aliphatic; R 1 , R 2 and R 3 are independently selected from hydrogen, hydroxy, amino, halogen, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, CF 3 , CN, NO 2 , N 3 , sulfonyl, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic.