Patent ID: 8778628

Claim:
An arylalkylamine compound represented by the formula [I-e]: the symbols in the formula represent the following meanings: Ar: represents phenyl or naphthyl, each of which is optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, cyano, halo-lower alkyl, lower alkyl, lower alkoxy, and lower alkylthio; R 1 : represents a group selected from the group consisting of optionally substituted phenyl, and optionally substituted monocyclic or bicyclic heterocyclic group, each of which is optionally substituted by substituent(s) selected from the group consisting of group Q1: <Substituent group Q1> halogen, cyano, nitro, oxo group, hydroxy, carboxy, lower alkyl optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy, hydroxy, lower alkoxy and halo-lower alkoxy, lower alkoxy optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy and hydroxy, amino optionally mono- or di-substituted by a group selected from the group consisting of lower alkyl, and halo-lower alkyl, 5 to 6-membered monocyclic heterocyclic group selected from the group consisting of tetrazole, pyridazinyl, and partially saturated cyclic group thereof, which is optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy, hydroxy, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy and acyl, phenyl optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, carboxy, hydroxy, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy and acyl, and acyl; n: is an integer of 1 to 3; X: represents —CH 2 —, —CO—, —(CH 2 ) m —CO—, —CH(R 2 )—CO—, —(CH 2 ) p —Y—(C(R 3 )(R 4 )) q —CO—, —NH—CO— or —N(R 5 )—CO—; in the above-mentioned respective definitions of the X, the bonding arm described at the left end represents a bond with R 1 ; m is an integer of 1 to 3; p is an integer of 0 to 2; q is an integer of 0 to 2; Y: represents —O— or —SO 2 —; R 2 : represents phenyl or lower alkyl; R 3 , R 4 : each independently represents hydrogen atom or lower alkyl; R 5 : represents lower alkyl; or a pharmaceutically acceptable salt thereof.