Patent ID: 7189758

Claim:
A compound of Formula (I) wherein: R 1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R 1 is independently C 1 –C 5 alkyl, C 2 –C 5 alkenyl, C 2 –C 5 alkynyl, C 3 –C 8 cycloalkyl, aryl, C 1 –C 5 alkoxy, aryloxy, C 1 –C 5 alkanoyl, aroyl, C 1 –C 5 alkoxycarbonyl, C 1 –C 5 alkanoyloxy, aminocarbonyloxy, C 1 –C 5 alkylaminocarbonyloxy, aminocarbonyl, C 1 –C 5 alkylaminocarbonyl, C 1 –C 5 alkanoylamino, C 1 –C 5 alkoxycarbonylamino, C 1 –C 5 alkylsulfonylamino, C 1 –C 5 alkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, nitro, amino wherein the nitrogen atom is optionally independently mono- or di-substituted by C 1 –C 5 alkyl or aryl; or ureido wherein either nitrogen atom is optionally independently substituted with C 1 –C 5 alkyl; or C 1 –C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone, wherein each substituent group of R 1 is optionally independently substituted with one to three substituent groups selected from methyl, halogen, hydroxy, oxo, cyano, trifluoromethyl, and amino; R 2 and R 3 are each independently hydrogen or C 1 –C 5 alkyl, or R 2 and R 3 together with the carbon atom they are commonly attached to form a C 3 –C 8 spiro cycloalkyl ring; R 4 is CH 2 or C═O; R 5 is carbocycle, heterocyclyl, aryl, heteroaryl, carbocycle-C 1 –C 8 alkyl, aryl-C 1 –C 8 alkyl, aryl-C 1 –C 8 haloalkyl, heterocyclyl-C 1 –C 8 alkyl, heteroaryl-C 1 –C 8 alkyl, carbocycle-C 2 –C 8 alkenyl, aryl-C 2 –C 8 alkenyl, heterocyclyl-C 2 –C 8 alkenyl, or heteroaryl-C 2 –C 8 alkenyl, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R 5 is independently C 1 –C 5 alkyl, C 2 –C 5 alkenyl, C 2 –C 5 alkynyl, C 3 –C 8 cycloalkyl, phenyl, C 1 –C 5 alkoxy, phenoxy, C 1 –C 5 alkanoyl, aroyl, C 1 –C 5 alkoxycarbonyl, C 1 –C 5 alkanoyloxy, aminocarbonyloxy, C 1 –C 5 alkylaminocarbonyloxy, aminocarbonyl, C 1 –C 5 alkylaminocarbonyl, C 1 –C 5 alkanoylamino, C 1 –C 5 alkoxycarbonylamino, C 1 –C 5 alkylsulfonylamino, C 1 –C 5 alkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, nitro, amino wherein the nitrogen atom is optionally independently mono- or di-substituted by C 1 –C 5 alkyl; or ureido wherein either nitrogen atom is optionally independently substituted with C 1 –C 5 alkyl; or C 1 –C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone; and R 6 is group B: or a tautomer, prodrug, or salt thereof.