Patent ID: 8450500

Claim:
A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, wherein: each R 1 and R 2 is independently —OH or —OR 9 and R 9 is a lower alkyl; R 3 is —X 50 R 50 , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl represented by R 3 is optionally and independently substituted with C 1 -C 3 alkyl, halo, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, —N(R 12 ) 2 , cyano, —C(O)OR 12 , —C(O)N(R 12 ) 2 , C(O)R 12 , —NR 12 C(O)R 12 or phenyl; each R 4 and R 5 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl represented by R 4 or R 5 is optionally and independently substituted with C 1 -C 3 alkyl, halo, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, —N(R 12 ) 2 , cyano, —C(O)OR 12 , —C(O)N(R 12 ) 2 , C(O)R 12 , —NR 12 C(O)R 12 or phenyl; each R 7 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl represented by R 7 is optionally and independently substituted with C 1 -C 3 alkyl, halo, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, —N(R 12 ) 2 , cyano, —C(O)OR 12 , —C(O)N(R 12 ) 2 , C(O)R 12 , —NR 12 C(O)R 12 or phenyl; each R 10 and R 11 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl represented by R 10 or R 11 is optionally and independently substituted with C 1 -C 3 alkyl, halo, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, —N(R 12 ) 2 , cyano, —C(O)OR 12 , —C(O)N(R 12 ) 2 , C(O)R 12 , —NR 12 C(O)R 12 or phenyl; or R 10 and R 11 , taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl, each independently and optionally substituted with C 1 -C 3 alkyl, halo, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, —N(R 12 ) 2 , cyano, —C(O)OR 12 , —C(O)N(R 12 ) 2 , C(O)R 12 , —NR 12 C(O)R 12 or phenyl; R 12 is hydrogen or C 1 -C 3 alkyl; R 50 is an optionally substituted aryl or an optionally substituted heteroaryl, each independently and optionally substituted with C 1 -C 3 alkyl, halo, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxy, —N(R 12 ) 2 , cyano, —C(O)OR 12 , —C(O)N(R 12 ) 2 , C(O)R 12 , —NR 12 C(O)R 12 or phenyl; X 50 is a divalent group selected from a C 1 -C 4 alkylene, NR 7 , C(O), C(S), C(NR 7 ), and S(O) p ; Y is O or S; each Z is independently C 1 -C 4 alkyl or halo; and each p is independently 0, 1 or 2.