Patent ID: 7629121

Claim:
A method of identifying a human individual for increased risk for vascular pathology the method comprising the step of: (a) determining whether the individual's genome comprises a Notch1 single-nucleotide polymorphism (SNP) allele causing Notch 1 haploinsufficiency and predetermined to be associated with an increased risk for vascular pathology, wherein the presence of the allele identifies the individual as at increased risk for vascular pathology, wherein the determining step comprises detecting the allele, wherein the SNP is selected from the group consisting of G1862A (R621H), C2542A (E848K), G2816A (R939Q), C3322T (R1108X), G3839A (R1280H), C4310T (A1437V), 4515Del (H1505del), G4826A (R1609H), C6817T (R2273C), and G6856A (V22861).