Patent ID: 7576175

Claim:
A compound having the formula: wherein R 1 is selected from the group consisting of —H, a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group, a C 1 -C 4 haloalkyl group, and a halogen; R 2 is selected from the group consisting of —H, a C 1 -C 4 alkyl group, and a C 3 -C 8 cycloalkyl group; X is a peptide having the following structure: -X 1 -X 2 -X 3 -Y, wherein X 1 is selected from the group consisting of derivatives of lysine, derivatives of ornithine (Orn) and derivatives of α,γ-diaminobutyric acid (Dbu), wherein said derivatives are formed by acylation of the ε-amino group in lysine, δ-amino group in Orn or γ-amino group in Dbu with a member selected from the group consisting of trans-3-(3-pyridyl)acrylic acid, L-pyroglutamic acid, trans-4-cotinine carboxylic acid, levulinic acid, Boc-1-amino cyclopropane-1-carboxylic acid, 2-pyrazine carboxylic acid, 3-pyridine propionic acid, butyric acid, 3-oxo-1-indancarboxylic acid, valeric acid, (S)-(+)-oxo-4-phenyl-3-oxazolidineacetic acid, Boc-D-Tic, 4-(dimethylamino)phenylacetic acid, hexanoic acid, phenylpropionic acid, 4-chlorophenylacetic acid, bromophenylacetic acid, 1-naphthylacetic acid, 2-phenoxybutyric acid and 2,4-dichlorophenylacetic acid; X 2 is a negatively charged amino acid selected from the group consisting of α-aminohexanedioic acid (Aad), α-aminooctanedioc acid (Asu), homoaspartic acid (HoAsp), γ-carboxy-glutamic acid and 4-carboxyphenylalanine (Phe(4-COOH)); X 3 is a hydrophobic amino acid; Y is a peptide fragment having m independently selected amino acids; and m is an integer of from 0 to 20.