Patent ID: 7612053

Claim:
A method for treating a tetracycline responsive state in a mammal, comprising administering to said mammal a 7-substituted fused ring tetracycline compound of formula (I): wherein: X is CR 6 R 6′ ; R 4 and R 4′ are each alkyl; R 5 is hydrogen or hydroxyl; R 6 and R 6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl; Y and Y′ are each independently optionally substituted C, N, O, or S; m is 1 or 2; and pharmaceutically acceptable salts thereof; such that the tetracycline responsive state is a bacterial infection that is selected from the group consisting of S. pnuemoniae, E. hirae, H influenzae , and M catarrhalis.