Patent ID: 8000522

Claim:
A method for three-dimensional imaging in a non-calibrated geometry, wherein the method is performed using a processor or computer, the method comprising: acquiring a plurality of projection images through an imaging volume; estimating an imaging geometry using at least one of fiducial markers or anatomical features or regions represented in the projection images, wherein estimating the imaging geometry comprises: identifying locations of the fiducial markers or anatomical features in some or all of the plurality of projection images; establishing an estimate of the imaging geometry; estimating locations of the fiducial markers or anatomical features in the projection images based on the estimate of the imaging geometry; computing a projection error between the estimated locations of the fiducial markers or anatomical features and the identified locations of the respective fiducial markers or anatomical features for at least one projection image; and updating the estimated imaging geometry based on the projection error; and reconstructing a configurable volumetric representation of some or all of the imaging volume using the estimated imaging geometry, wherein the act of reconstructing accounts for one or more geometry dependent factors.