Patent ID: 6887868

Claim:
A compound of Formula I: wherein: R 1 and R 2 are independently hydrogen, C 1-8 alkyl, substituted C 1-8 alkyl, aryl(C 1-8 )alkylene, cycloalkyl, substituted cycloalkyl or heteroaryl (C 1-8 )alkylene; R 3 and R 4 are independently hydrogen, C 1-8 alkyl, aryl(C 1-8 )alkylene, or heteroaryl (C 1-8 )alkylene; R 5 and each R 6 are independently hydrogen, C 1-8 alkyl, aryl, heteroaryl, aryl(C 1-8 )alkylene or heteroaryl(C 1-8 )alkylene; each R 7 is independently halo, cyano, nitro, trifluoromethyl, azido, C 1-8 alkyl, hydroxy, NR a R b , C 1-8 alkoxy, aryloxy, â€”C(â•O)NR a R b , â€”C(â•S)NR a R b , â€”C(â•NR c )NR a R b , â€”NR c C(â•NR c )NR a R b , â€”NR c C(â•S)NR a R b , â€”NR c C(O)NR a R b , â€”NR c C(NCN)NR a R b , aryl or heteroaryl; X is O; n is 0, 1, 2, or 3; m is 1; R a and R b are each independently hydrogen, C 1-8 alkyl, aryl, aryl(C 1-8 )alkylene, heteroaryl, or heteroaryl(C 1-8 )alkylene; or R a and R b , together with the nitrogen to which they are attached, form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each R c is independently hydrogen, C 1-8 alkyl, aryl(C 1-8 )alkylene or heteroaryl(C 1-8 )alkylene; R d and R e are each independently hydrogen, C 1-8 alkyl, aryl, aryl(C 1-8 )alkylene, heteroaryl, or heteroaryl(C 1-8 )alkylene; the bond represented by â€”â€”â€” is a single bond or a double bond; R 8 is absent when the bond represented by â€”â€”â€” is a double bond; or when the bond represented by â€”â€”â€” is a single bond, R 8 is hydrogen, halo, hydroxy, C 1-8 alkyl, C 1-8 alkoxy, aryl(C 1-8 )alkylene, heteroaryl(C 1-8 )alkylene, aryloxy(C 1-8 )alkylene or heteroaryloxy(C 1-8 )alkylene; wherein any aryl or heteroaryl of R 1 -R 8 and R a -R e is optionally substituted with one to four halo, cyano, nitro, trifluoromethyl, azido, C 1-8 alkyl, hydroxyl, NR f R g , C 1-8 alkoxy, aryloxy, â€”C(â•O)NR f R g , â€”C(â•S)NR f R g , â€”C(â•NR h )NR f R g , â€”NR h C(â•NR h ) NR f R g , â€”NR h C(â•S) NR f R g , â€”NR h C(O)NR f R g , â€”NR h C(NCN)NR f R g , aryl or heteroaryl; wherein R f and R g are each independently hydrogen, C 1-8 alkyl, aryl, aryl(C 1-8 )alkylene, heteroaryl, or heteroaryl(C 1-8 )alkylene; or R f and R g , together with the nitrogen to which, they are attached, form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each R h is independently hydrogen, C 1-8 alkyl, aryl(C 1-8 )alkylene or heteroaryl(C 1-8 )alkylene; wherein any alkylene is optionally partially unsaturated; or a pharmaceutically acceptable salt thereof.