Patent ID: 7332157

Claim:
A method of administering to a human recipient a graft from a human, the method comprising: administering to the recipient an amount of chemotherapy sufficient to allow the induction of mixed chimerism in the recipient, wherein the chemotherapy comprises administering to the recipient a chemotherapeutic agent which is an antineoplastic agent, an antimetabolite, or a radiomimetic agent; administering to the recipient, an amount of thymic irradiation sufficient to kill or otherwise inactivate recipient thymocytes; administering to the recipient, an antibody that depletes T cells; administering to the recipient, donor hematopoietic progenitor cells, wherein the hematopoietic progenitor cells are enriched for CD34 + cells prior to the administering; implanting the graft into the recipient, wherein the graft is an organ graft selected from a heart, pancreas, liver, or kidney graft; and administering to the recipient, a non-chronic course of an immunosuppressant.