Patent ID: 8242113

Claim:
A novel oxazolidinone derivative represented by Chemical Formula 1, an in vivo hydrolysable ester thereof, an in vivo hydrolysable phosphate ester thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof: wherein R 1 represents hydrogen, (C 1 -C 6 )alkyl, or (C 3 -C 6 )cycloalkyl; Y represents —O—, or —N(R 2 )—; R 2 represents hydrogen, cyano, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, —(CH 2 ) m OC(═O)R 11 , —(CH 2 ) m C(═O)R 12 , —(CH 2 ) m C(═S)R 12 , or —SO 2 R 13 , wherein the alkyl of R 2 may be further substituted by one or more substituent(s) selected from a group consisting of (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, halogen, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl(C 2 -C 6 )alkynyl, hydroxyl, (C 3 -C 6 )cycloalkyl and cyano; R 11 through R 13 independently represent hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, amino, (C 3 -C 6 )cycloalkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, or (C 1 -C 6 )alkylcarbonyl, wherein the alkyl, alkoxy or amino of R 11 through R 13 may be further substituted by one or more substituent(s) selected from halogen, amino, hydroxyl, cyano, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylcarbonyloxy and hydroxy(C 1 -C 6 )alkyl; m represents an integer from 0 to 2; X 1 and X 2 independently represent hydrogen or fluorine; P represents —O—, —NH—, or a five-membered aromatic heterocycle with the following structure Q represents hydrogen, —C(═O)R 3 , —C(═S)R 4 , —C(═O)NR 5 R 6 , —C(═S)NR 5 R 6 , or a five-membered aromatic heterocycle with a structure selected from the followings: R 3 and R 4 independently represent hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 3 -C 6 )cycloalkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; R 5 and R 6 independently represent hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, or (C 2 -C 6 )alkenyl; R 7 represents hydrogen, halogen, (C 1 -C 6 )alkyl, or (C 3 -C 6 )cycloalkyl; and the alkyl of R 3 through R 7 may be further substituted by one or more substituent(s) selected from a group consisting of hydroxyl, cyano, halogen, (C 1 -C 6 )alkylcarbonyloxy and amino.