Patent ID: 7910703

Claim:
An antagonist of IL-23 and of IL-17A or IL-17F, comprising an anti-IL-23 antibody or fragment thereof which binds the p19 subunit of IL-23, and a cross-reactive antibody or fragment thereof, which binds IL-17A or IL-17F , wherein the anti-IL-23 antibody or fragment thereof comprises a variable heavy region polypeptide as shown in SEQ ID NO: 268 and a variable light region polypeptide as shown in SEQ ID NO: 266, and wherein the cross-reactive antibody or fragment thereof comprises the CDRs of an antibody selected from the group consisting of: a) the antibody produced by the hybridoma of ATCC Patent Deposit Designation PTA-7987; b) the antibody produced by the hybridoma of ATCC Patent Deposit Designation PTA-7988; and c) the antibody produced by the hybridoma of ATCC Patent Deposit Designation PTA-7989 .