Patent ID: 7902361

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 and R 5 are each independently H, C(OR j′ ) or a hydrocarbyl group optionally substituted by one or more R 6 groups; R 2 , R 3 , and R 4 are each independently H, alkyl or alkenyl, each of which may be optionally substituted with one or more R 7 groups; R 6 and R 7 are each independently halogen, NO 2 , CN, (CH 2 ) m OR a , O(CH 2 ) n OR b , (CH 2 ) p NR c R d , CF 3 , COOR e , CONR f R g , COR h , SO 3 H, SO 2 R i , SO 2 NR j R k , (CH 2 ) q NR a′ COR g′ , R f′ , (CH 2 ) r NR b′ SO 2 R h′ , SO 2 NR d′ R i′ , SO 2 NR e′ (CH 2 ) s OR c′ , heterocycloalkyl or heteroaryl, wherein said heterocycloalkyl and heteroaryl may be optionally substituted by one or more substituents selected from aralkyl, sulfonyl, R m and COR n ; R g′ , R h′ , R i′ and R j′ are each independently selected from alkyl, aryl, aralkyl and heteroaryl, each of which may be optionally substituted with one or more substituents selected from halogen, OH, NO 2 , NH 2 CF 3 and COOH; m, p, q and r are each independently 0, 1, 2 or 3; n and s are each independently 1, 2, or 3; and R a-n and R a′-f′ are each independently H or alkyl, with the proviso that the compound is other than: 3,4-Dimethyl-5-[2-(3-nitro-phenylamino)-pyrimidin-4-yl]-3H-thiazol-2-one; 5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Hydroxy-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Chloro-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Methoxy-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(3-Hydroxy-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Dimethylamino-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Fluoro-3-nitro-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 3,4-Dimethyl-5-[2-(4-methyl-3-nitro-phenylamino)-pyrimidin-4-yl]-3H-thiazol-2-one; 5-[2-(4-Fluoro-3-methyl-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(3-Iodo-4-methyl-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Chloro-3-methyl-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one; 5-[2-(4-Iodo-3-phenylamino)-pyrimidin-4-yl]-3,4-dimethyl-3H-thiazol-2-one.