Patent ID: 8501795

Claim:
A compound having the structure I wherein HET-1 is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms: wherein Y can be N or CH, Z can be N or C, and wherein HET-1 may optionally be substituted with up to three R 7 , R 8 , and R 9 substituents individually selected from hydrogen, C 1 -C 6 alkyl; halogen; cyano, halo(C 1 -C 6 )alkyl; aryl, alkoxy and C 1 -C 6 hydroxyalkyl, and wherein * denotes the attachment point, Q is phenyl, optionally substituted with one, two or three R 2 , R 3 , R 4 , R 5 , and R 6 substituents, wherein R 2 , R 3 , R 4 , R 5 , and R 6 are each selected independently from hydrogen, C 1 -C 6 alkoxy and halogen; or a monocyclic 5-membered or 6-membered heteroaromatic group containing 1 or 2 heteroatoms, -L- is a linker selected from —S—CH 2 —, —CH 2 —S—, —CH 2 —CH 2 —, —CH═CH—, and —C≡C—, R 1 is selected from H, C 1 -C 6 alkyl; C 1 -C 6 alkyl(C 3 -C 8 )cycloalkyl; C 1 -C 6 hydroxyalkyl, CH 2 CN, CH 2 C(O)NH 2 , C 1 -C 6 arylalkyl, and C 1 -C 6 alkylheterocycloalkyl, with the proviso that the compound is not 1H-Benzimidazole, 2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(2-pyrazinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; 1H-Benzimidazole, 2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)methyl]thio]-; 1H-Benzimidazole, 1-ethyl-5-(1-piperidinylsulfonyl)-2-[[[3-(2-thienyl)-1H-1,2,4-triazol-5-yl]thio]methyl]-; 1H-Benzimidazole, 6-methyl-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(3-pyridinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; Imidazo[1,2-a]pyridine, 8-methyl-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; Imidazo[1,2-a]pyridine, 6-chloro-2-[[[3-(2-thienyl)-1,2,4-triazol-5-yl]thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(4-pyridinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; Imidazo[1,2-a]pyridine, 6-methyl-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 1H-Benzimidazole, 2-[[[3-(2-pyridinyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; imidazo[1,2-a]pyridine, 6-chloro-2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; 3H-Imidazo[4,5-b]pyridine, 2-[[(3-phenyl-1H-1,2,4-triazol-5-yl)thio]methyl]-; or 1H-Benzimidazole, 2-[[[3-(2-furanyl)-1H-1,2,4-triazol-5-yl]methyl]thio]-; and pharmaceutically acceptable salts thereof, with the proviso that when the linker (L) is —CH 2 —S— then HET-1 is neither imidazo[1,2-a]pyridine nor imidazo[1,2-a]pyrimidine.