Patent ID: 6903219

Claim:
A process comprising reacting Compound A with Compound B to produce Compound C, wherein the reaction is conducted in the presence of a catalyst that can facilitate the transfer of the allylic group from Compound B to the non-aromatic hydroxy group of Compound A, a ligand that can help the catalyst facilitate the transfer of the allylic group from Compound B to the hydroxy group of Compound A, and a solvent that is an aprotic solvent that facilitates the reaction; at a temperature that facilitates the transfer of the allylic group from comoound B to the hydroxy group of Compound A and wherein E is selected from the group consisting of O and NR 6 ; Y is selected from the group consisting of H, benzyl, Si(C 1-4 alkyl) 3 , Si(Ph) r (C 1-4 alkyl) (3-r) (r=1, 2, or 3), SO 2 R, C(R 1 R 2 )OR, C(R 1 R 2 )OC(O)XR, C(R 1-2 R 2-1 )OR, and C(R 1-2 R 2-1 )OC(O)XR, and C(O)XR; X is selected from the group consisting of O, S, and a bond; R is selected from the group consisting of C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, aryl, and heteroaryl; R 1 is selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, aryl, and heteroaryl; R 2 is selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, aryl, and heteroaryl; C(R 1-2 R 2-1 ) is a 3 to 6 membered ring, where the members of the ring are selected from the group consisting of C, O, and S; R 3 is independently selected from the group consisting of H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, aryl, and heteroaryl; R 4 is selected from the group consisting of C 1 -C 10 alkyl and aryl; R 6 is selected from the group consisting of C 1 -C 6 alkyl and aryl; and wherein each of the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, benzyl, aryl, heteroaryl, and R 1-2 R 2-1 may be substituted with one or more substituents.