Patent ID: 8367699

Claim:
A compound of general formula (A) and pharmaceutically acceptable salt or an ester thereof, wherein X is C═O, R 1 is selected from substituted or unsubstituted morpholinyl, substituted or unsubstituted pyrrolidinyl and substituted or unsubstituted piperazinyl, —NX 1 (X 2 ), with X 1 and X 2 independently selected from H, alkyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, wherein R 2 is a heteroaryl, selected from the group of pyridyl, imidazolyl, pyrazolyl, quinolinyl, indolyl, benzoimidazolyl, benzoxazoyl, benzisoazoyl, benzthiazolyl, isoquinolinyl, pyrrolyl oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, oxadiazolyl, thiadiazolyl, thiophenyl, indazolyl, tetrazolyl, pyrazinyl, primidinyl and pyridazinyl groups said heteroaryl being optionally substituted with at least one substituent independently selected from the group of F, Cl, Br, I, OH, NH 2 , SH, N 3 , NO2, alkyl, heteroalkyl, methylamino, dimethylamino or cyanide, wherein R 3 is selected from aryl, heteroaryl, arylalkyl or heteroarylalkyl, wherein R 4 is selected from —H, —F, —Cl, —Br, —I, —NO 2 , hydroxy, lower alkyl, lower alkenyl or lower alkinyl, lower alkoxy, —CH 2 OCH 3 and —CH 2 OCH 2 CH 3 , —NY 1 (Y 2 ), with Y 1 and Y 2 independently selected from H, lower alkyl, lower alkoxy alkyl, hetero alkyl, aryl or heteroaryl.