Patent ID: 7700768

Claim:
A process for producing a compound of Formula (IV) wherein R 1 is an aryl ring, which ring is optionally substituted; R 2 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl, heteroarylC 1-10 alkyl, heterocyclic, or a heterocyclylC 1-10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; R 3 is a C 1-10 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl, heteroarylC 1-10 alkyl, heterocyclic, or a heterocyclylC 1-10 alkyl moiety; and wherein each of these moieties are optionally substituted; R b is hydrogen, C 1-2 alkyl, NR c , hydroxy, thio, C 1-2 alkoxy, or S(O) m C 1-2 alkyl; R c is hydrogen or C 1-2 alkyl; R d is hydrogen or C 1-2 alkyl; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 R 14 , or (CH 2 ) n NR 2 R 4 ; m is 0 or an integer having a value of 1 or 2; n is 0 or an integer having a value of 1 to 10; R 4 and R 14 are each independently selected from hydrogen, optionally substituted C 1-6 alkyl, optionally substituted aryl or an optionally substituted aryl-C 1-4 alkyl, or R 4 and R 14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR 9 , and wherein the ring is optionally substituted; R 6 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, heterocyclyl, heterocyclyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl or a heteroarylC 1-10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, is optionally substituted; R 9 is hydrogen, C(Z)R 6 , optionally substituted C 1-10 alkyl, optionally substituted aryl or optionally substituted arylC 1-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof; which process comprises reacting a compound of the formula wherein R 1 and R 3 are as defined herein for Formula (IV), and X 1 is a C 1-10 alkyl, aryl or heteroaryl moiety; under cyclization conditions to yield a compound of Formula (B): wherein R 1 and R 3 are as defined herein for Formula (IV), and X 1 is a C 1-10 alkyl, aryl or heteroaryl moiety; and if necessary oxidizing the sulfur moiety in S—X 1 to a sulfoxide or sulfone, and if necessary displacing the sulfide, sulfoxide or sulfone of Formula (B) with a nucleophile selected from a primary or secondary alkylamine, arylamine, heteoarylamine, arylthiol, heteroarylthiol, alkylthiol, alkyl alcohol, aryl alcohol, heteroaryl alcohol, or a carbon nucleophile to yield a compound of Formula (IV).