Patent ID: 8828391

Claim:
A method of treating a patient suffering from a non-small cell lung cancer (NSCLC) driven by deregulated Human Epidermal Growth Factor Receptor (HER/Human EGFR), wherein: the patient has a tumor expressing mutated forms of the EGFR, and the patient has acquired resistance to tyrosine kinase inhibitor (TKI) treatment, comprising administering to a patient in need of such treatment a flexible and active regimen for combining an irreversible tyrosine kinase inhibitor (TKI) and a Human EGFR targeted monoclonal antibody (mAB), wherein in this method the TKI is administered according to a continuous regimen based on an average daily dose in the range of 10 to 50 mg and the mAB is co-administered according to a dosing regimen ranging from an average weekly iv dose of 50 to 500 mg/m 2 repeated thrice, twice or once a week, once in two weeks, once in three weeks or at least once monthly, wherein the method results in overcoming the acquired resistance to TKI treatment.