Patent ID: 7816534

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein; R 1 is selected from: (1) cycloheteroalkyl, and (2) heteroaryl, wherein each cycloheteroalkyl, and heteroaryl is optionally substituted with one to four substituents independently selected from R b ; R 2 is aryl-C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a , and each aryl is optionally substituted with one to four substituents independently selected from R b ; R 3 is selected from: (1) hydrogen, and (2) C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a ; R 4 is selected from: (1) hydrogen, and (2) C 1-4 alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R a ; R 5 is C 1-8 alkyl substituted with —OR d , wherein R d is heteroaryl and wherein heteroaryl is unsubstituted or substituted with one to three substituents selected from R h ; each R a is independently selected from: (1) —OR d , (2) —NR c S(O) m R d , (3) halogen, (4) —SR d , (5) —S(O) m NR c R d , (6) —NR c R d , (7) —C(O)R d , (8) —CO 2 R d , (9) —CN, (10) —C(O)NR c R d , (11) —NR c C(O)R d , (12) —NR c C(O)OR d , (3) —NR c C(O)NR c R d , (14) —CF 3 , (15) —OCF 3 , and (16) cycloheteroalkyl; each R b is independently selected from: (1) —OR d , (2) halogen, (3) —CN, (4) —CF 3 , (5) —OCF 3 , (6) cycloheteroalkyl; (7) C 1-4 alkyl, (8) oxo, (9) phenyl, (10) benzyl, and (11) heteroaryl; each R c is independently selected from: (1) hydrogen, and (2) C 1-4 alkyl, and each R d is independently selected from: (1) hydrogen, (2) C 1-4 alkyl, (3) C 2-6 alkenyl, (4) cycloalkyl, (5) cycloalkyl-C 1-4 alkyl, (6) cycloheteroalkyl, (7) cycloheteroalkyl-C 1-4 alkyl, (8) phenyl, (9) heteroaryl, (10) phenyl-C 1-4 alkyl, and (11) heteroaryl-C 1-4 alkyl, or R c and R d together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N—R g , each R c and R d may be unsubstituted or substituted with one to three substituents selected from R h ; each R g is independently selected from: (1) C 1-4 alkyl, and (2) —C(O)C 1-4 alkyl; each R h is independently selected from: (1) halogen, (2) C 1-10 alkyl, (3) —O C 1-4 alkyl, (4) —S C 1-4 alkyl, (5) —CN, (6) —CF 3 , and (7) —OCF 3 , m is selected from 1 and 2.