Patent ID: 7919581

Claim:
A compound having the general structure A or a pharmaceutically acceptable salt thereof: Het-L-P (A) wherein: R is phenylene; R 1 is hydrogen, straight-chained alkyl, branched alkyl, halogen, nitro or NHC(O)CH 2 C 4 H 3 S; P is a peptide consisting of the sequence selected from the group consisting of RPTTLNLGG (SEQ ID NO:1), PTTLNLGG (SEQ ID NO:2), LNLGG (SEQ ID NO:3), RPTTLNL (SEQ ID NO:4), GRKKRRGRRRGGRPTTLNLGG (SEQ ID NO:5), GGLNLTTPRGGRRRQRRKKRG (SEQ ID NO:6, (D amino acids)), GRPTTLNLGG (SEQ ID NO:7); Xaa (0-8) LNLGGXaa (0-8) (SEQ ID NO:8), PTTLNL (SEQ ID NO:10), GGLNLTTPR (SEQ ID NO:11), GGLNLTTP (SEQ ID NO:12), GGLNL (SEQ ID NO:13), LNLTTPR (SEQ ID NO:14), LNLTTP (SEQ ID NO: 15), LNL, N-myristoilated RPTTLNLGG (SEQ ID NO:1), N-myristoilated PTTLNLGG (SEQ ID NO:2), N-myristoilated LNLGG (SEQ ID NO:3), N-myristoilated RPTTLNL (SEQ ID NO:4), N-myristoilated PTTLNL (SEQ ID NO:10), N-myristoilated LNL, C-myristoilated GGLNLTTPR (SEQ ID NO:11), C-myristoilated GGLNLTTP (SEQ ID NO:12), C-myristoilated GGLNL (SEQ ID NO:13), C-myristoilated LNLTTPR (SEQ ID NO:14), C-myristoilated LNLTTP (SEQ ID NO:15) and C-myristoilated LNL, and L is a linking moiety selected from the group consisting of: (a) structure II: (b) —(CH 2 ) n —, (c) —O—(CH 2 ) n —O—, (d) —(CH 2 )-phenylene-, and (e) —NHSO 2 —(CH 2 ) n —CONH—, wherein n is an integer having a value between 2 and 8, and wherein Het is connected to the linking moiety L via the phenylene substituent R, and wherein the linking moiety L links the phenylene substituent R to the peptide P.