Patent ID: 6969707

Claim:
A metallic complex having the Formula XII: or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: at least one of R 1 , R 2 , R 3 , or R 4 , is, independently, a moiety selected from the group consisting of: â€”(CH 2 ) n â€”X; â€”(CH 2 ) n â€”Y; â€”CH 2 CH=CH 2 ; CH 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 OCH 3 ; CH 2 CO 2 CH 2 CH 3 ; (OCH 2 CH 2 ) m â€”X; â€”Y 2 C(Z 1 ) 3 , wherein: Z 1 is CH 2 OCH 2 (CH 2 ) n X or CH 2 OCH 2 (CH 2 ) n Y; â€”(CH 2 ) n C(O)Y 2 C(Z 2 ) 3 , wherein: Z 2 is CH 2 OCH 2 CH 2 C(O)Y 2 C(Z 4 ) 3 , Z 4 is CH 2 OCH 2 CH 2 Z 5 , and Z 5 is CO 2 (CH 2 CH 2 O)m, â€”COOH; â€”CONR 2 ; â€”CONRâ€² 2 ; â€”OPO 3 H 2 ; â€”PO 3 H 2 ; â€”SO 3 H; â€”NH 2 ; NRâ€² 2 ; or â€”NRâ€² 3 + ; â€”(CH 2 ) n OCH 2 C(CH 2 OH) 3 ; â€”(CH 2 ) n OCH 2 CH(CH 2 OH) 2 ; â€”(CH 2 ) n OCH 2 C(CH 2 OH) 2 (CH 3 ); â€”(CH 2 ) n OCH 2 C[CH 2 OCH 2 C(CH 2 OH) 3 ] 3 ; and â€”CH 2 ) n OCH 2 C[CH 2 OCH 2 C(CH 2 O[CH 2 CH 2 O] m CH 2 CH 2 OX) 3 ] 3 , wherein n is an integer from 1 to 10; m is an integer from 1 to 200; X is â€”COOH; â€”CONH 2 ; â€”CONRâ€² 2 ; â€”OPO 3 H 2 ; â€”PO 3 H 2 ; â€”SO 3 H; â€”NH 2 ; â€”NRâ€² 2 ; or â€”NRâ€² 3 + , further wherein Râ€² is an alkyl group; Y is â€”OH or â€”(Oâ€”CH 2 CH 2 ) m â€”W; where W is â€”OH, or â€”(Oâ€”(CH 2 CH 2 ) m ; Y 2 is selected from the group consisting ofâ€”(CH 2 ) n Oâ€”, â€”(CH 2 ) n NHâ€”, and (CH 2 ) n S; and wherein the remaining R 1 , R 2 , R 3 , and R 4 are hydrogen; M is selected from the group consisting of Mn, Fe, Ni and V, and Ligand 1 and Ligand 2 are, independently, absent or selected from the group consisting of halide, oxo, aquo, hydroxo, and alcohol.