Patent ID: 8012463

Claim:
A coordinate complex in the form of a polymer micelle, said polymer micelle encapsulating a complex of diaminocyclohexane platinum (II) and a block copolymer comprising a structure of the general formula (A): PEG-block-poly(carbo) (A) wherein PEG represents a poly(ethylene glycol) chain segment and poly(carbo) represents a polymer chain segment having a carboxyl group and selected from the group consisting of poly(glutamic acid) chain segment and poly(aspartic acid) chain segment; wherein diaminocyclohexane platinum (II) is immobilized with the block copolymer via bonding between carboxyl anion of poly(carbo) and the platinum and wherein copolymer is represented by the following general formula (1) or (2), or a salt thereof: wherein R 1 represents a hydrogen atom or an unsubstituted or substituted linear or branched C 1-12 alkyl group; L 1 represents —(CH 2 ) b —NH— wherein b represents an integer of 1 to 5; L 2 represents —(CH 2 ) c —CO— wherein c represents an integer of 1 to 5; R 2 represents a methylene group or ethylene group; R 3 respectively and independently represents an atom or a group selected from the group consisting of a hydrogen atom, a benzyl oxycarbonyl group, a t-butyl oxycarbonyl group, an acetyl group, a trifluoroacetyl group, a benzyl carbonyl group, a benzhydryl carbonyl group, an acryloyl group and methacryloyl group; R 4 respectively and independently represents a group selected from the group consisting of a hydroxyl group, a benzyloxy group, a t-butyloxy group, a methoxy group, a benzhydryloxy group, an allyloxy group and a vinyl phenyloxy group; R 5 respectively and independently represents a hydrogen atom, an alkali metal ion, a group selected from the group consisting of a benzyl group, a benzhydryl group and a C 1-6 alkyl group; m represents an integer of 5 to 20,000; n represents an integer of 2 to 5,000; and x represents an integer of 0 to 5,000, with the proviso that x is not larger than n, and that hydrogen atoms or alkali metal ions account for 50% or more of R 5 's the number of which is the sum of n-x and x wherein the equivalent ratio of platinum (Pt) of diaminocyclohexane platinum (II) to a carboxyl group of the block copolymer (Pt/COO − ) is from 0.3 to 1.