Patent ID: 6962915

Claim:
A compound having the formula: or a pharmaceutically-acceptable salt or prodrug, thereof, wherein: Y is —C(═O)NR 1 —, —NR 1 C(═O)—, —NR 1 C(═O)NR 1 —, —NR 1 SO 2 —, —SO 2 NR 1 —, —C(═O)—, —OC(═O)—, or —CO 2 —, provided, however, that when R 6 is hydrogen, Y is not —NR 1 C(═O)—; B is selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, hydroxy, alkoxy, aryl, cycloalkyl, heteroaryl, and heterocyclo; or when Y is —C(═O)NR 1 —, B also may be selected from —C(═O)R 8 , —C(═O)NR 8 R 9 , and —CO 2 R 8 , R 1 is hydrogen, C 1-4 alkyl, or substituted C 1-4 alkyl; R 2 is hydrogen or C 1-4 alkyl; R 3 is hydrogen, methyl, perfluoromethyl, hydroxy, methoxy, halogen, cyano, NH 2 , or NH(CH 3 ); R 4 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, cycloalkyl, heteroaryl, or heterocyclo; R 5 is selected from hydrogen, halogen, cyano, alkyl, substituted alkyl, —C(═O)R 11 , —CO 2 R 11 , —S(═O)R 12 , —SO 2 R 12 , —SO 3 R 12 , —OR 11 , —SR 11 , —NR 11 R 12 , —C(═O)NR 11 R 12 , —NR 11 C(═O)R 12 , NR 11 CO 2 R 12 , —NR 11 SO 2 R 12 , —SO 2 NR 11 R 12 , cycloalkyl, aryl, heterocyclo and heteroaryl; R 6 is selected from halogen, cyano, nitro, A 1 -R 13 , -A 1 -O-A 2 -R 13 , -A 1 -S-A 2 -R 13 , -A 1 -C(═O)-A 2 -R 13 , -A 1 -OC(═O)-A 2 -R 13 , -A 1 -S(═O)-A 2 -R 13 , -A 1 -SO 2 -A 2 -R 13 , -A 1 -CO 2 -A 2 -R 13 , -A 1 -NR 13 -A 2 -R 14 , -A 1 -NR 15 C(═O)-A 2 -R 13 , -A 1 -NR 15 C(═O)NR 16 -A 2 -R 13 , -A 1 -NR 15 CO 2 -A 2 -R 13 , -A 1 -NR 15 SO 2 -A 2 -R 13 , -A 1 -NR 15 SO 2 NR 16 -A 2 -R 13 , -A 1 -SO 2 NR 15 -A 2 -R 13 , and -A 1 -C(═O)NR 15 -A 2 -R 13 ; A 1 is —(CR 17 R 18 ) r —; A 2 is —(CR 19 R 20 ) s —; R 8 and R 9 are selected from hydrogen, alkyl, substituted alkyl, aryl, cycloalkyl, heteroaryl, and heterocyclo, or may form together with the N atom to which these are attached, a heteroaryl or heterocyclo ring; R 11 , R 12 , R 13 , and R 14 are selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, cycloalkyl, heteroaryl, and heterocyclo, or may form together with the N atom to which these are attached, a heteroaryl or heterocyclo ring, provided that when R 12 or R 13 is attached to a sulfonyl group (as in —S(═O)R 12 , —SO 2 R 12 , —SO 3 R 12 , -A 1 -S(═O)R 13 , -A 1 -SO 2 R 13 , and -A 1 -SO 3 R 13 ), R 12 and R 13 are not hydrogen; R 15 and R 16 are selected from hydrogen, C 1-4 alkyl, hydroxy, hydroxyC 1-4 alkyl, and aminoC 1-4 alkyl; R 17 , R 18 , R 19 , and R 20 are selected from hydrogen, C 1-4 alkyl, halogen, cyano, hydroxy, hydroxyC 1-4 alkyl, haloC 1-4 alkyl, C 1-4 haloalkoxy, amino, C 1-4 alkylamino, and aminoC 1-4 alkyl; m is 0, 1 or 2; and r and s are selected from 0, 1, 2, 3, and 4.