Patent ID: 7063950

Claim:
An isolated nucleic acid molecule selected from the group consisting of: (a) a nucleic acid molecule that encodes an α1 E -subunit of a human calcium channel and comprises the coding portion of the sequence of nucleotides set forth in SEQ ID NO: 24; (b) a nucleic acid molecule that encodes an α1 E subunit of a human calcium channel and comprises the coding portion of the sequence of nucleotides set forth in SEQ ID NO: 27; (c) a nucleic acid molecule that encodes an α 1E subunit of a human calcium channel and comprises the sequence of nucleotides set forth in SEQ ID NO: 25, wherein the encoded α1 E subunit has a molecular weight greater than about 120 kilodaltons (kD) and is a full-length α1 E subunit of a human calcium channel that can form an ion channel; (d) a nucleic acid molecule comprising a sequence of nucleotides with codons that are degenerate to the codons in the coding portion of the sequence of nucleotides set forth in (a) or (b) above; (e) a nucleic acid molecule comprising a sequence of nucleotides that encodes an α1 E subunit of a human calcium channel that comprises a sequence of amino acid sequence encoded by the nucleic acid molecule of any one of (a), (b), (c) or (d) above; and (f) a nucleic acid molecule that encodes an α1 E subunit of a human calcium channel polypeptide, wherein the nucleic acid molecule hybridizes under stringent wash condition, 0.1.times.SSC, 0.1% SDS at 65° C., to the complement of the nucleotide sequence of (a), (b), (c), (d) or (e) above.