Patent ID: 8609655

Claim:
A method for treating gastrointestinal epithelial injury induced by hypoxia or ischemia comprising administering to a subject in need thereof, wherein the subject does not have a diarrhea, a therapeutically effective amount of a calcimimetic compound of Formula I wherein: X 1 and X 2 , which may be identical or different, are each a radical chosen from CH 3 , CH 3 O, CH 3 CH 2 O, Br, Cl, F, CF 3 , CHF 2 , CH 2 F, CF 3 O, CH 3 S, OH, CH 2 OH, CONH 2 , CN, NO 2 , CH 3 CH 2 , propyl, isopropyl, butyl, isobutyl, t-butyl, acetoxy, and acetyl radicals, or two of X 1 may together form an entity chosen from fused cycloaliphatic rings, fused aromatic rings, and a methylene doxy radical, or two of X 2 may together form an entity chosen from fused cycloaliphatic rings, fused aromatic rings, and a methylene dioxy radical; provided that X 2 is not a 3-t-butyl radical; n ranges from 0 to 5; m ranges from 1 to 5; and the alkyl radical is chosen from C 1 -C 3 alkyl radicals, which are optionally substituted with at least one group chosen from saturated and unsaturated, linear, branched, and cyclic C 1 -C 9 alkyl groups, dihydroindolyl and thiodihydroindolyl groups, and 2-, 3-, and 4-piperidinyl groups; or a pharmaceutically acceptable salt thereof.