Patent ID: 7514461

Claim:
A compound represented by Formula I wherein: —A—B— is —CH 2 —CH 2 —; —CH═CH—; —CH 2 —O—; —CH 2 —S—; or —CH 2 —N—; n is 0 to 5; R 1 is C 1-4 alkyl or halo-(C 1-4 )-alkyl; R 2 is —C(O)OR a ; halogen or dihalovinyl; aryl optionally substituted with substituted with one or more substituents selected from alkyl, haloalkyl, hydroxy, alkoxy, halogen, oxo, cyano, nitro, amino, —SO 2 NR 2 , and —C(O)OR; -Het, —CH-(Het) 2 ; or —CH=Het; where Het is saturated, partially unsaturated or unsaturated heterocyclyl optionally substituted with one or more substituents selected from alkyl, haloalkyl, hydroxy, alkoxy, halogen, oxo, cyano, nitro, amino, —SO 2 NR 2 , and —C(O)OR; R 3 is hydrogen; halogen; optionally substituted C 1-6 alkyl; C 2-20 alkenyl; —OR; nitro; —(CR 2 ) m C(O)OR a ; —(CR 2 ) m C(O)NR b R c ; —(CR 2 ) m N(OH)C(O)NR b R c ; —(CR 2 ) m NR b R c ; —(CR 2 ) m NR b —SO 2 —R a ; —(CR 2 ) m S(O) 0-2 R a ; —(CR 2 ) m SO 2 NR b R c ; —CR=Het, wherein Het is a saturated, partially unsaturated or unsaturated heterocycyl optionally substituted with one or more substituents selected from alkyl, haloalkyl, hydroxy, alkoxy, halogen, oxo, cyano, nitro, amino, —SO 2 NR 2 , and —C(O)OR; cycloalkyl, aryl or saturated, partially unsaturated or unsaturated heterocyclyl, all rings optionally substituted with C 1-6 alkyl, hydroxy, alkoxy, nitro, amino, or —C(O)OR; R 4 is hydrogen; optionally substituted C 1-4 alkyl, C 2-12 alkenyl, hydroxyalkyl, acyl, glucoside, phosphoryl, phosphoryloxyalkyl, carboxyalkylcarbonyl, aminoalkylcarbonyl, or alkylketocarbonyl; R 5 and R 6 are independently of each other C 1-6 alkyl, C 2-20 alkenyl, or halogen; m is 0 to 3; R is hydrogen or C 1-4 alkyl; R a is hydrogen, optionally substituted C 1-4 alkyl, optionally substituted C 2-12 alkenyl, optionally substituted aryl, optionally substituted cycloalkyl, or optionally substituted heterocyclyl; R b and R c are independently of each other hydrogen, C 1-4 alkyl, hydroxyalkyl, aminoalkyl, optionally substituted aryl, optionally substituted benzyl, or optionally substituted heterocyclyl; or R b and R c taken together with the atom to which they are attached form a 5 to 8 membered aromatic, saturated or unsaturated ring, optionally incorporating one additional atom chosen from N, O, or S and optionally substituted with a substituent selected from the group consisting of lower alkyl, halo, cyano, alkylthio, lower alkoxy, oxo, phenyl, benzyl and carboxy; with the proviso that if —A—B— is —CH 2 —CH 2 — or —CH═CH—, and R 3 , R 5 , or R 6 are hydrogen or C 1-3 -alkyl then R 2 is not —C(O)OR, halogen, or aryl; further provided that if R 2 is -Het and R 3 is C 1-6 -alkyl, then n=0 and Het is not 2,2-dimethyl-[1,3]dioxolan-4-yl, oxiran-2-yl, thiazole-2-yl, oxazole-2-yl, thiazole-4-yl or benzofuran-2-yl; and further provided that if R 2 is aryl, then R 3 is not optionally substituted alkyl; or single stereoisomers, mixtures of stereoisomers, or pharmaceutically acceptable salts thereof.