Patent ID: 8088746

Claim:
An oligomeric compound having the formula: G-[T-L] j -[R-L] q -R-[L-T] r -E wherein: each T is a monomer of Formula V: wherein independently for each monomer having Formula V: Bx is a heterocyclic base moiety; one of Z 1 and Z 2 is H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl and the other one of Z 1 and Z 2 is C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl; one of Q 1 and Q 2 is H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, thiol or substituted thiol and the other one of Q 1 and Q 2 is C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, thiol or substituted thiol; or Q 1 and Q 2 together are methylene (═CH 2 ); each R is a β-D-2′-deoxyribonucleoside; each L is an internucleoside linking group; G and E are each, independently, H, a hydroxyl protecting group, a linked conjugate group or a 5′ or 3′-terminal group; wherein each substituted group is mono or poly substituted with substituent groups independently selected from halogen, OJ 1 , SJ 1 , NJ 1 J 2 , N 3 , COOJ 1 , CN, O—C(═O)NJ 1 J 2 , N(H)C(═NH)NJ 1 J 2 , N(H)C(═O)N(H)J 2 or N(H)C(═S)N(H)J 2 ; each J 1 and J 2 is, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 aminoalkyl or a protecting group; q is from 7 to about 15; j is 0 or from 1 to about 5; r is 0 or from 1 to about 5; and the sum of j and r is at least 1.