Patent ID: 8148544

Claim:
A method of making a compound of the formula A: or a salt or N-oxide thereof, wherein Alk is an alkyl group; R 51 and R 52 are, the same or different independently one from the other, H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted heterocycloalkylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylamidoalkyl, substituted or unsubstituted arylalkylamidoalkyl, substituted or unsubstituted heteroarylamidoalkyl, substituted or unsubstituted heteroarylalkylamidoalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted arylalkoxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, haloalkyl, or R 51 and R 52 , together with the carbon atom to which they are attached, form a substituted or unsubstituted alkenyl group; M 1 is N or CR 49 , wherein R 49 is H or substituted or unsubstituted alkyl; M 2 is N or CR 50 , wherein R 50 is H or substituted or unsubstituted alkyl; R 38 is H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted heterocycloalkylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylamidoalkyl, substituted or unsubstituted heteroarylamidoalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted arylalkoxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, or haloalkyl; R 47 is H, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, or halo; and R 48 is H, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, or halo; wherein the method comprises converting a compound of the formula B: or a salt or N-oxide thereof; into a compound of the formula C: or a salt or N-oxide thereof; wherein R 47 , R 48 , Alk, M 1 , and M 2 are defined above; and reacting the compound of formula C with a compound of the formula D: or a salt thereof; wherein J 3 is a leaving group and R 38 , R 51 , and R 52 are defined above, to give a compound of formula A or a salt or N-oxide thereof.