Patent ID: 7332528

Claim:
A method of producing a liquid spray composition for administration of a bioactive material to the nasal cavity consisting essentially of: a) a pharmacologically acceptable non aqueous liquid carrier selected from the group consisting of diglycerides, triglycerides and mixtures thereof in which said bioactive material is directly insoluble, b) a pharmacologically acceptable water insoluble ester of a water soluble acid soluble in said carrier, c) a pharmacologically acceptable water soluble glycol soluble in said ester, comprising from about 1 to about 5 wt. % of the total composition, d) a pharmacologically acceptable water soluble bio-active material soluble in said glycol but directly insoluble in said carrier said spray being non-aqueous tasteless, odorless, which consists essentially of the sequential steps of dissolving the bio-active material of (d) in a glycol of (c), dissolving said solution of (d) in (c) in an ester of (b) and dissolving said solution of {(d) in (c) in (b)}in a carrier of (a).