Patent ID: 7993656

Claim:
A modified Clostridial toxin comprising: a) a Clostridial toxin enzymatic domain that executes an enzymatic target modification step of a Clostridial toxin intoxication process; b) a Clostridial toxin translocation domain that executes a translocation step of a Clostridial toxin intoxication process; c) a translocation facilitating domain that facilitates a translocation step of a Clostridial toxin intoxication process, wherein the translocation facilitating domain is a Clostridial toxin translocation facilitating domain or an enveloped virus fusogenic peptide domain; d) an altered targeting domain that selectively binds to a non-Clostridial toxin receptor present on a Clostridial toxin target cell and executes a cell binding step of a Clostridial toxin intoxication process, wherein the altered targeting domain is a glucagon like hormone peptide that selectively binds to a glucagon like hormone receptor; and e) a protease cleavage site; wherein cleavage of the protease cleavage site converts the single-chain form of the modified Clostridial toxin into the di-chain form.