Patent ID: 8835627

Claim:
A process for the synthesis of ivabradine of formula (I): wherein a compound of formula (VI): is subjected to a lactamisation reaction, in the presence of a coupling agent and a base, in an organic solvent, to yield ivabradine of formula (I), which may be converted into an addition salt thereof with a pharmaceutically acceptable acid selected from hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, acetic acid, trifluoroacetic acid, lactic acid, pyruvic acid, malonic acid, succinic acid, glutaric acid, fumaric acid, tartaric acid, maleic acid, citric acid, ascorbic acid, oxalic acid, methanesulphonic acid, benzenesulphonic acid and camphoric acid, and into hydrates thereof.