Patent ID: 7786301

Claim:
A method for producing a compound of formula 13A: the method comprising: (i) reacting a compound of formula 7 with a primary amine Compound of Formula 8 or a hydrochloride salt thereof, in the presence of a base to form a compound of formula 9: wherein L is a protecting group which is acetate, propionate, a pivaloyl protecting group, —OC(O)R 5 , or —NC(O)R 5 , wherein R 5 is H or C 1-12 alkyl and, wherein R 4 is alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl or heteroaryl, and R 4 is optionally substituted with one or more halo, nitro amino, or —C(O)OR 50 substituents, wherein —R 50 is H, Alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or aryl; and (ii) treating the compound of formula 9 with a base to remove the protecting group thereby forming a compound of Formula 13A wherein Compound 7 is Compound 7A, Compound 8 is Compound 8A, Compound 9 is Compound 9A and the base in step (i) is sodium bicarbonate, and wherein the reaction is carried out in the presence of N,N-dimethyl acetamide as a solvent: according to the following scheme wherein, DMA is N,N-dimethyl acetamide Me is CH 3 —; and OAc is acetate.