Patent ID: 8217045

Claim:
A compound of formula I wherein X is selected from N or CH; R 1 is selected from NH 2 , NHheteroaryl, NHCON(C 1-7 alkyl) 2 , NHCOR 5 ,; R 4 is a phenyl substituted by trifluoromethyl and at least one further substituent selected from imidazolyl, piperazinyl, C 1-7 Alkyl-piperazinyl-C 1-7 Alkyl, and 9-methyl-3,9-diazabicyclo[3.3.1]nonan-3yl; wherein said imidazolyl of R 4 is substituted with either 1 to 2 methyl groups or a methyl and a benzyl group; R 5 is selected from C 1-7 alkyl, C 3-7 cycloalkyl, C 2-7 alkenyl, C 2-7 alkynyl, C 3-5 heterocycloalkyl, aryl, heteroaryl; or a pharmaceutically acceptable salt thereof, with the proviso that Compound of formula I is not a compound selected from 6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(9-methyl-3,9-diaza-bicyclo[3.3.1]non-3-ylmethyl)-3-trifluoromethyl-phenyl]-amide, 6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [3-(4-methyl-1-piperazinyl)-5-(trifluoromethye)phenyl]-amide, 6-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide, 6-(6-Amino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide, and 7-(6-Amino-pyrimidin-4-yloxy)-isoquinoline-4-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide.