Patent ID: 8093215

Claim:
A method for restructuring a biological tissue containing collagen fibrils selected from a venous tissue, a cardiac valvular tissue, a cutaneous tissue, a subcutaneous tissue, a tissue of a muscular tendon, a tissue of a muscular fascia, and a tissue of a muscular aponeurosis, said method comprising the following operational steps: a) bringing into contact a biological tissue comprising collagen fibrils with a cross-linking chemical composition able to induce cross-linking of collagen fibrils consequent to activation through electromagnetic radiation; b) activating said cross linking chemical composition through exposure to an electromagnetic radiation for a time and under conditions for cross-linking of collagen fibrils to occur, thus c) obtaining a restructured biological tissue containing the collagen fibrils cross-linked in step b); wherein said cross-linking chemical composition comprises one or more photoactive bioflavonoids selected from the group consisting of proanthocyanidin, catechin, epicatechin, epigallo catechin, epicatechin gallate, epigallocatechin gallate, quercetin, tannic acid, and any combination thereof.