Patent ID: 7045550

Claim:
A method for reducing or inhibiting chemotherapy- or radiotherapy-induced alopecia in a patient undergoing treatment with a chemotherapeutic agent or radiation therapy, which comprises administering to the patient's scalp a pharmaceutical preparation comprising at least one polyamine effector selected from the group consisting of spermine, putrescine, norspermidine, cadaverine, spermidine, agmatine, NG-hydroxy-arginine, DL-alpha-difluoromethylorinithine, BE-3-3-3, SL-11237, SL-11159, SL-11047, SL-11144, SL-11158, SL-11160, SL-11227, SL-11179, SL-11101, SL-11092, SL-11094, SL-11093, SL-11341, SL-11122, SL-11172, SL-11103, SL-11244, SL-11246, and SL-11179, and a topical delivery vehicle for locally delivering the polyamine effector to cells lining hair follicles, in an amount and for a time effective to reduce or inhibit the chemotherapy- or radiotherapy-induced alopecia in the patient.