Patent ID: 6864249

Claim:
A compound having formula I: and pharmaceutically acceptable salts thereof wherein n is 1 or 3; A is hydrogen, alkyl, C 3-7 cycloalkyl, aryl, —SO 2 R 1 , —SO 3 R 1 , —COR 1 , —CO 2 R 2 , —PO(R 1 ) 2 , —PO(OR 1 ) 2 , —(CH 2 ) m CO 2 R 1 , —(CH 2 ) m SO 2 R 1 , —(CH 2 ) m SO 3 R 1 , or —(CH 2 ) m PO(OR 1 ) 2 , wherein R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, —(CH 2 ) m aryl, or —NR 3 R 4 , and R 2 is C 1-6 alkyl, C 3-7 cycloalkyl, aryl, —(CH 2 ) m aryl, or alkenyl, m is 1, 2, or 3, wherein aryl is unsubsituted or substituted phenyl or 5-6 membered aromatic heterocyclic ring, R 3 and R 4 are independently hydrogen, C 1-6 alkyl, or C 3-7 cycloalkyl; B is hydrogen or C 1-6 alkyl; C and D are independently phenyl unsubsituted or substituted with one or two substituents selected from C 1-4 alkyl, C 1-4 alkoxy, CF 3 , methylenedioxy, halogen, hydroxy, or —NR 3 R 4 , C 3-7 cycloalkyl, or a 5-6 membered heterocyclic ring system which may be saturated or unsaturated, and which consists of carbon atoms and 1-3 heteroatoms selected from the group consisting of N, O, and S; E is wherein X is S, O, or NR 5 , Y and Z are independently N or CR 6 , wherein R 5 is hydrogen or C 1-4 alkyl and R 6 is hydrogen, halogen, CF 3 or C 1-4 alkyl, and F is —C(NH)N(R 7 ) 2 , —C(NH 2 )NN(R 7 ) 2 , —C(NH 2 )NOH, or —CH 2 NH(R 7 ) 2 wherein R 7 is the same or different, R 7 is hydrogen, C 1-4 perfluoroalkyl or C 1-4 alkyl.