Patent ID: 6891044

Claim:
A method of preparing a compound or a salt of formula I: wherein: R 1 is a substituted or unsubstituted (C 3 -C 8 )aryl or 4 to 10 membered heteroaryl, or a group of the formula —CH═CH—R 3 or CH═N—R 3 ; R 3 is a substituted or unsubstituted (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 8 )aryl, 4-10 membered heterocycloalkyl, or 4-10 membered heteroaryl; Y is O, S, C═CH 2 , C═O, S═O, SO 2 , CH 2 , CHCH 3 , NH, or N—(C 1 -C 8 alkyl); R 8 is a substituted or unsubstituted (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )aryl, 4-10 membered heterocycloalkyl, 4-10 membered heteroaryl, 4-10 membered alkoxyl, or 4-10 membered aryloxyl; and R 10 , R 11 , and R 12 are independently selected from hydrogen, halogen, and (C 1 -C 8 )alkyl; comprising the step of: treating a compound of formula Xa: wherein R 1 , R 10 , R 11, R 12 and Y are as described above; with a compound of formula Xb: wherein R 8 is as described above; in the presence of a suitable coupling agent, optionally in the presence of a suitable catalyst, a suitable base, and a suitable solvent.