Patent ID: 8143269

Claim:
A pharmaceutical composition comprising a pharmaceutically acceptable diluent, excipient or binder, and a compound of Formula (XIV): wherein: X is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl wherein cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with at least one R 3 ; Y is a bond, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, NR 2 , O, S, NR 2 (C 1 -C 6 alkyl), O(C 1 -C 6 alkyl), S(C 1 -C 6 alkyl), NR 2 (C 2 -C 6 alkenyl), O(C 2 -C 6 alkenyl), or S(C 2 -C 6 alkenyl); wherein C 1 -C 6 alkyl or C 2 -C 6 alkenyl are optionally substituted with at least one R 3 ; Z is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl wherein cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with at least one R 4. ; each R 1 is independently selected from H, F, Cl, Br, I, —CN, —NO 2 , —OH, —CF 3 -OCF 3 , OR 9 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 8 heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, —NHS(═O) 2 R 8 , —S(═O) 2 N(R 9 ) 2 , —N(R 9 )S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 8 , —N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —N(R 9 )C(═O)N(R 9 ) 2 , —N(R 9 )C(═O)OR 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —OC(═O)N(R 9 ) 2 , —CON(R 9 ) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 2 R 8 ; R 2 is H, C 1 —C 6 alkyl, or C 3 -C 8 cycloalkyl; R 3 and R 4 are each independently selected from F, Cl, Br, I, —CN, —NO 2 , —OH, —CF 3 , —OCF 3 , —OR 9 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 8 heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, —NHS(═O) 2 R 8 , —S(═O) 2 N(R 9 ) 2 , —N(R 9 )S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 8 , —N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —N(R 9 )C(═O)N(R 9 ) 2 , —N(R 9 )C(═O)OR 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —OC(═O)N(R 9 ) 2 , —CON(R 9 ) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 2 R 8 ; or two R 3 together with the atoms to which they are attached form a heterocycloalkyl group having at least one O, NH, or S; each R 8 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; each R 9 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; or pharmaceutically acceptable salt, pharmaceutically acceptable prodrug, or pharmaceutically acceptable solvate thereof.