Patent ID: 7160726

Claim:
A composition comprising: conditioned cell culture media, or an extract thereof, comprising at least one culture-derived growth factor, wherein the at least one growth factor comprises at least one of vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), interleukin-3 (IL-3), IL-6, and IL-8; at least one culture-derived antioxidant, wherein the at least one antioxidant comprises at least one of glutathione, glutathione peroxidase, glutathione reductase, glutathione disulfide, catalase, superoxide dismutase, alpha-tocopherol, gamma-tocopherol, ubiquinol-9, ubiquinone 9, ascorbic acid, cysteine, and cystine; and at least one culture-derived soluble collagen; and an appropriate carrier, and wherein the cell culture media is conditioned by human fibroblasts in three-dimensional culture.