Patent ID: 8492561

Claim:
A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof, wherein: “ ” represents a double bond “—CR 14 ═CR 15 —” or a triple bond “—C≡C—”; A is C 6-10 aryl, heterocycle, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; B is C 6-10 aryl, heterocycle, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; R 1 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 2 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 3 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 4 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 5 is H, halogen, —OC 1-8 alkyl, O 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 6 is H, halogen, —OC 1-8 alkyl, O 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 7 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , C 6-10 aryl, heterocycle, C 3-8 cycloakyl, C 3-8 cycloalkenyl, NR 12 R 13 or hydroxyl; R 8 is the same or independently halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; L 1 is O, S, NH or CH 2 ; R 11 is H or O 1-8 alkyl; a is 0, 1, 2 or 3; R 12 is H or O 1-8 alkyl; R 13 is H or O 1-8 alkyl; R 14 is H or O 1-8 alkyl; and R 15 is H or O 1-8 alkyl.