Patent ID: 8133909

Claim:
A compound of formula wherein i) Ar 1 is heteroaryl; Ar 2 is phenyl and Ar is phenyl or heteroaryl; or ii) Ar 1 is phenyl; Ar 2 is heteroaryl and Ar is phenyl or heteroaryl; or iii) Ar 1 is heteroaryl; Ar 2 is heteroaryl and Ar is phenyl or heteroaryl; R 1 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkoxy; R 2 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or lower alkoxy substituted by halogen; each R 3 is independently hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, lower alkyl substituted by cycloalkyl, C(O)O-lower alkyl, C(O)NH-lower alkyl, —(CH 2 ) m —O-lower alkyl, lower alkoxy, lower alkoxy substituted by halogen, cyano, SO 2 -lower alkyl, cycloalkyl, or where Ar 2 is phenyl and o is 2, R 3 optionally is R 3 and R 3′ which together with the corresponding carbon atoms to which they are attached form a non aromatic ring containing the groups —(CH 2 ) 4 —, —(CH 2 ) 3 —, —CH 2 —S(O) 2 —CH 2 —, —N(CH 3 )—C(O)—N(CH 3 )—, —(CH 2 ) 2 —O—, —O—(CH 2 ) 2 —O—, —O—(CH 2 ) 2 —CH(OH)—, —O—(CH 2 ) 2 —, —O—(CH 2 ) 3 —, —O—CH 2 —C(O)—N(CH 3 )—, —N(CH 3 )—C(O)—(CH 2 ) 2 —, or —O—C(CH 3 ) 2 —O—; R 4 and R 5 are each independently hydrogen, hydroxy, lower alkyl, lower alkoxy, CH 2 NH 2 , O—C(O)-lower alkyl, or —NRR′ or R 4 and R 5 together are ═O; R and R′ are each independently hydrogen, —S(O) 2 -lower alkyl, cycloalkyl, —(CH 2 ) m —OH, —(CH 2 ) m —O-lower alkyl,—C(O)CH(NH 2 )-phenyl, or oxetan-3-yl optionally substituted by CH 2 NH 2 , or R and R′ together with the N atom to which they are attached form a heterocycloalkyl ring, optionally containing in addition to the N atom a further heteroatom, selected from the group consisting of N, S and O; n is 1, 2 or 3; o is 1, 2 or 3; p is 1, 2 or 3; and m is 0, 1 or 2; or a pharmaceutically suitable acid addition salt, optically pure enantiomer, racemate or diastereomeric mixture thereof.