Patent ID: 7709532

Claim:
A method of improving the bioavailability of a renin inhibitor, which method comprises co-administering, to a mammal in need such treatment, a combination of a renin inhibitor and an efflux protein inhibitor, wherein the efflux protein inhibitor is PSC833 and the renin inhibitor is a σ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide derivative represented by the formula wherein R 1 is C 1-4 alkoxy-C 1-4 alkoxy or C 1-4 alkoxy-C 1-4 alkyl: R 2 is C 1-4 alkyl or C 1-4 alkoxy; and R 3 and R 4 are independently branched C 1-4 alkyl; or a pharmaceutically acceptable salt thereof.