Patent ID: 8067189

Claim:
A method for treating colon cancer in a mammal in need thereof comprising: (a) measuring an expression level of an RNA transcript or its expression product in a colon cancer tissue biological sample from the mammal wherein the RNA transcript is a collagen type IV transcript; (b) administering a VEGFR-2 modulator comprising [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester to said mammal; (c) following the administering of step (b), measuring in the mammal said expression level of said RNA transcript or its expression product in said cancer tissue biological sample, wherein a decrease in said expression level of step (c) compared to said expression level of step (a) indicates that the mammal will respond therapeutically to said method of treating colon cancer.