Patent ID: 6858624

Claim:
A compound of the formula (I) wherein R 1 is —COOR 4 , wherein R 4 is a group of formula R 2 and R 3 , together with the benzo ring to which they are attached, form a bicyclic ring system selected from the following: wherein one of the carbon atoms of ring A can optionally be replaced with oxygen or N(C 1 -C 6 )alkyl; wherein R 11 and R 12 are selected, independently, from hydrogen, (C 1 -C 6 )alkyl; and (C 1 -C 6 )alkoxy-(C 0 -C 6 )alkyl- wherein the total number of carbon atoms does not exceed six and wherein any of the alkyl moieties may optionally be substituted with from one to seven fluorine atoms; nitro, cyano, halo, amino, (C 1 -C 6 )alkylamino-, ((C 1 -C 6 )alkyl) 2 amino-, —CO 2 R 5 , —CONR 6 R 7 , —SO 2 NR 8 R 9 , —C(═O)R 10 , —XC(═O)R 10 , phenyl, monocyclic heteroaryl, or when attached to a nitrogen atom, a group of formula: each R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is selected, independently, from hydrogen and (C 1 -C 6 )alkyl, or R 6 and R 7 , or R 8 and R 9 together with the nitrogen to which they are attached, form a pyrrolidine, piperidine, morpholine, azetidine, piperazine, —N—(C 1 -C 6 )alkylpiperazine or thiomorpholine ring, or a thiomorpholine ring wherein the ring sulfur is replaced with a sulfoxide or sulfone; and each X is, independently, (C 1 -C 6 )alkylene; with the proviso that when R 1 is H, then at least one of R 11 or R 12 must be a group of formula: attached to a nitrogen atom in the ring formed by groups R 2 and R 3 , and forming an ammonium ion center on that nitrogen atom if necessary to accommodate the existing bonding relationships; and pharmaceutically acceptable salts of such compounds.