Patent ID: 6916823

Claim:
A method for treating a patient with Parkinson's disease resulting from a dopamine-related dysfunction, said method comprising the steps of: administering to the patient a full D 1 agonist selected from the group consisting of dinapsoline, dinoxyline, dihydrexidine, analogs and derivatives of said agonists, and combinations thereof, wherein said agonist has a half-life of less than 6 hours and wherein said agonist is administered periodically at a dose resulting in a first tissue concentration of agonist capable of activating D 1 dopainine receptors to produce a therapeutic effect; and reducing said agonist dose at least once every 24 hours to obtain a second lower tissue concentration of agonist wherein said second concentration of agonist results in suboptimal activation of D 1 dopamine receptors for a period of time sufficient to prevent induction of tolerance.