Patent ID: 8097730

Claim:
A compound of formula (I) wherein: R 1 is selected from the group consisting of hydrogen, carboxy, alkyl, halogenated C 1-4 alkyl, hydroxy substituted C 1-4 alkyl, aryl, aralkyl, heteroaryl, —C(O)— alkyl, —C(O)—(halogenated C 1-4 alkyl), —C(O)O—C 1-4 alkyl, —C(O)O-aryl, —C 1-4 alkyl- and S(O) 0-2 —C 1-4 alkyl; wherein the aryl or heteroaryl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, halogenated C 1-4 alkyl, halogenated C 1-4 alkoxy, cyano, nitro, amino, C 1-4 alkylamino, —NR C —C(O)—C 1-4 alkyl, —C(O)O—C 1-4 alkyl and NR C —C(O)-(halogenated C 1-4 alkyl); wherein each R C is hydrogen or C 1-4 alkyl; R 2 is selected from the group consisting of C 1-4 alkyl and halogenated C 1-4 alkyl; X is selected from the linkage group consisting of —C(O)—, —C(S)—, and —C(O)—C(O)—; Y is selected from the linkage group consisting of —C(O)—, —C(O)—C(O)—, and —S(O) 1-2 ; Z is selected from the group consisting of N or O; provided that when Z is O, R 1 is absent; A is O or S; R 3 is absent or is selected from the group consisting of hydrogen, halogen, C 1-4 alkyl, halogenated C 1-4 alkyl, cyano, nitro, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, —O—C 1-4 alkyl, —S(O) 0-2 —C 1-4 alkyl, —NR B —C(O)—C 1-4 alkyl, benzyl, —O-phenyl, —C(O)-phenyl and —S(O) 0-2 -phenyl; wherein R B is hydrogen or C 1-4 alkyl; R 4 is absent or is selected from the group consisting of hydrogen, halogen, C 1-4 alkyl, halogenated C 1-4 alkyl, cyano, nitro, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, —O—C 1-4 alkyl, —S(O) 0-2 —C 1-4 alkyl, —NR B —C(O)—C 1-4 alkyl, benzyl, —O-phenyl, —C(O)-phenyl and —S(O) 0-2 -phenyl; wherein R B is selected from hydrogen and C 1-4 alkyl; or a pharmaceutically acceptable salt thereof.