Patent ID: 8362021

Claim:
A method of increasing the bioavailability of a compound of formula 1 in a patient receiving treatment to modulate N-type calcium channels, comprising orally administering to the patient a compound of formula 1, or a pharmaceutically acceptable salt thereof, with food, wherein the compound of formula 1 is: wherein X is C or N; R 1 -R 5 are independently selected from C 1-6 alkyl, halo, CF 3 , OCF 3 , NO 2 , NR 2 , OR, SR, COR, COOR, CONR 2 , NROCR or OOCR, wherein R is H or C 1-4 alkyl, or any two substituents on the same ring may, along with the atoms to which they are joined, form a 5-7 membered ring; n 1 , n 2 , n 4 and n 5 are independently 0-5; and n 3 is 0-4.