Patent ID: 7157451

Claim:
A compound of the formula I* enantiomers, diasteriomers and pharmaceutically acceptable salts thereof, wherein X 1 , X 2 and X 3 , together with the atoms to which they are bonded, form a ring selected from: R 1 , R 5 , R 6 and R 7 are independently selected from groups of the formula —(CH 2 ) n -(Z 1 ) m -(CH 2 ) p -Z 2 ; R 2 is phenyl or substituted phenyl; R 4 is alkyl or substituted alkyl; Z 1 is —CZ 3 Z 4 -, —O—, —NZ 3 -, —S—, —SO—, —SO 2 —, —C(O)—, —C(O)Z 3 -, —C(O)NZ 4 , —C(S)—, —C(═NOZ 3 )-, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo; Z 2 is hydrogen; —OZ 5 , —OC(O)Z 5 , —NZ 5 -C(O)-Z 6 , —NZ 5 -CO 2 -Z 6 , —NZ 5 (C═O)—NZ 6 Z 7 , —NZ 5 Z 6 , —NO 2 , halo, —CN, —C(O)Z 5 , —CO 2 Z 5 , —C(S)Z 5 , —(C═NOZ 5 )Z 6 , —C(O)NZ 5 Z 6 , —C(S)NZ 5 Z 6 , —SZ 5 , —SOZ 5 , —SO 2 Z 5 , —SO 2 NZ 5 Z 6 , —CF 3 , alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo; Z 3 , Z 4 , Z 5 , Z 6 and Z 7 are independently hydrogen, halo, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclo, substituted carbocyclo, aryl, substituted aryl, heterocyclo, or substituted heterocyclo; or Z 3 , Z 4 , Z 5 , Z 6 and Z 7 may, in one or more pairs of two, together with the atoms to which they are bonded, form a carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic group; R 3 * is —C(O)NZ 5 *Z 6 *; Z 5 * and Z 6 * together with the nitrogen atom to which they are bonded form a heterocyclic group or substituted heterocyclic group, provided that Z 5 * and Z 6 * do not together form unsubstituted piperidinyl, substituted piperidinyl, unsubstituted pyrrolidinyl, or unsubstituted morpholinyl; n and p are independently selected from integers from 0 to 10 wherein, when m is 0, p is also 0; m is an integer selected from 0 or 1; and q is an integer selected from 1 to 3.