Patent ID: 8715728

Claim:
An extended release pellet formulation comprising: an inert pellet core; a first layer being an active ingredient layer comprising pramipexole or a pharmaceutically acceptable salt thereof and one or more wet binders and at least one further excipient; and a second layer provided on the first layer, the second layer being an extended release coating comprising a mixture of 10 to 85% by weight of a pH-dependent enteric-coating polymer, which is an anionic polymer, and 15 to 75% by weight of a pH-independent water swelling polymer, which is a quaternary ammonium substituted acrylic polymer, and optionally additionally containing a pore-forming component, the resulting pellet having a close to zero order in vitro release characteristic at acidic pH values up to pH 6.8, an accelerated release above pH 6.8 and a more accelerated release above pH 7.3.