Patent ID: 6946255

Claim:
A monoclonal antibody or active fragment of the monoclonal antibody that specifically reacts with a human or a mouse FAS ligand, wherein the antibody is produced by any one of hybridoma cell lines deposited as Accession Nos. FERM BP-5044 (Hybridoma NOK1), FERM BP-5045 (Hybridoma NOK 2), FERM BP-5046 (Hybridoma NOK3), FERM BP-5047 (Hybridoma NOK 4), FERM BP-5048 (Hybridoma NOK5) and FERM BP-5334 (Hybridoma KAY-10) in National Institute of Bioscience and Hyman-Technology, Agency of Industrial Science and Technology, wherein the active fragment is F(ab′) 2 , Fab′, Fab, Fv or recombinant Fv, and wherein the antibody produced by any one of the hybridoma cell lines deposited as Accession Nos. FERM BP-5044 (Hybridoma NOK1), FERM BP-5045 (Hybridoma NOK 2), FERM BP-5046 (Hybridoma NOK3), FERM BP-5047 (Hybridoma NOK 4) and FERM BP-5048 (Hybridoma NOK5) or active fragment of the monoclonal antibody reacts specifically with a human Fas ligand, and said antibody or fragment thereof inhibits apoptosis more than a control FAS-Ig chimera at a concentration of 0.01-8 μg/ml, and further wherein the antibody produced by the hybridoma cell line deposited as Accession No. FERM BP-5334 (Hybridoma KAY-10) or active fragment of the monoclonal antibody reacts specifically with the Fas ligands of cells derived from the B6 mouse and C3H mouse.