Patent ID: 7053085

Claim:
A compound having the structural formula I: or a pharmaceutically acceptable salt, enantiomer, diastereomer, prodrug or mixture thereof, wherein, Q is (CH 2 ) m , (CH 2 ) m C 6-10 aryl, (CH 2 ) m C 5-10 heterocyclyl, (CH 2 ) m C 3-10 heterocycloalkyl, (CH 2 ) m C 3-8 cycloalkyl, C(halo) 2 , said cycloalkyl, heterocycloalkyl, aryl or heterocyclyl unsubstituted or substituted with 1–3 groups of R a ; X represents O, Y represents CH 2 ; U represents H, C1–3 alkyl or is not present when W is ═O; W represents OH or ═O, provided that U is not present when W is ═O; R 1 represents (CH 2 ) p hydroxy, (CH 2 ) p CN, (CH 2 ) p CO 2 R 10 , (CH 2 ) n SO 3 R 6 , —(CH 2 ) p CF 2 SO 2 NH 2 , —(CH 2 ) p SO 2 NH 2 , —(CH 2 ) p CONHSO 2 R 2 , —(CH 2 ) p SO 2 NHCOR 2 , —(CH 2 ) p PO(OH) 2 , (CH 2 ) p CONHPO 2 R 6 , (CH 2 ) p CONHR 8 , (CH 2 ) p C 1-4 alkoxy, —(CH 2 ) p cycloalkyl, or (CH 2 ) n heterocyclyl, said heterocyclyl unsubstituted or substituted with 1 to 3 groups of R a and optionally containing an acidic hydroxyl group; R 2 independently represents C 1-10 alkyl, (CH 2 ) m C 6-10 aryl, (CH 2 ) m C 5-10 heterocyclyl, (CH 2 ) m C 3-10 heterocycloalkyl, (CH 2 ) m C 3-8 cycloalkyl, O—C 1-10 alkyl, O—C 6-10 aryl, O—C 3-10 cycloalkyl, O—C 3-10 heterocycloalkyl, O—C 3-10 heterocycloalkyl, said alkyl, cycloalkyl, heterocycloalkyl, aryl or hetrocyclyl unsubstituted or substituted with 1–3 groups of R a ; R 3 and R 4 independently represents hydrogen, halogen, or C 1-6 alkyl, or R 3 and R 4 may be taken together to form a 3–7 membered carbon ring optionally interrupted with 1–2 heteroatoms chosen from O, S, SO, SO 2 , and NR 9 ; R 6 and R 7 independently represents hydrogen, or C 1-4 alkyl; R 8 represents hydrogen, acyl, or sulfonyl; R 9 represents hydrogen, C 1-6 alkyl, said alkyl optionally substituted with 1–3 halogen, CN, OH, C 1-6 alkoxy, C 1-6 acyloxy or amino; R 10 represents hydrogen, C 1-10 alkyl, C 3-10 cyclcoalkyl, (CH 2 ) p C 6-10 aryl, (CH 2 ) p C 5-10 heterocyclyl, CR 6 R 7 OC(O)O C 3-10 cycloalkyl or CR 6 R 7 OC(O)O C 1-10 alkyl; Z represents a C≡C, O, S, (C(R b ) 2 ) n , or CH═CH; R b represents hydrogen, C 1-6 alkyl or halogen; R a represents C 1-6 alkoxy, C 1-6 alkyl, CF 3 , nitro, amino, cyano, C 1-6 alkylamino, halogen, SC 1-6 alkyl, SC 6-10 aryl, SC 5-10 heterocyclyl, CO 2 R 6 , OC 6-10 aryl, OC 5-10 heterocyclyl, CH 2 OC 1-6 alkyl, CH 2 SC 1-6 alkyl, CH 2 Oaryl, CH 2 Saryl; represents a double or single bond; p represents 0–3; n represents 0–4; and m represents 0–8.