Patent ID: 7838001

Claim:
Synthetic peptide in linear form or in a form cyclized by means of intercysteine disulphide bridges, having the general formula (I): Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω (SEQ ID NO: 23) wherein Δ is selected from the group consisting of a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH 3 CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group and an amine functional group, Z represents a peptide sequence, selected from the group consisting of the sequences of the formulae: Ξ 1 -Ser-Ξ 2 (II) Ξ 1 -Ser- (IV) Ξ 1 -Gln-Ξ 2 (V) Ξ 1 -Asn-Ξ 2 (VIII) wherein Ξ 1 represents a peptide sequence of 0 to 9 amino acids, and Ξ 2 represents a peptide sequence of 0 to 5 amino acids, Θ represents a peptide sequence of formula (XI): (AA 1 )-Gly-(AA 3 )-Leu-(AA 5 ) (XI): wherein (AA 1 ) is selected from the group consisting of a lysine residue and an arginine residue, (AA 3 ) is selected from the group consisting of a lysine residue and an arginine residue, (AA 5 ) is selected from the group consisting of an isoleucine residue and a valine residue, provided, however, that Θ never represents the peptide sequence Lys Gly Lys Leu Ile (SEQ ID NO: 14) or Lys Gly Lys Leu Val (SEQ ID NO: 18), Ω attached to the —CO— group of serine, is selected from the group consisting of: a hydroxyl (—OH) radical and a peptide sequence of formula (XII): Val-Σ-Ψ (XII) wherein Σ represents a sequence: (AA 6 )-Trp Asn-(AA 7 )-(AA 8 ) (XIII) wherein: (AA 6 ) represents an amino acid different from lysine, (AA 7 ) represents an amino acid, (AA 8 ) is selected from the group consisting of a serine and a threonine residue, and Ψ, attached to the —CO— residue of the free AA 8 amino acid, is selected from the group consisting of an OH group and a NH 2 group.