Patent ID: 8110577

Claim:
A compound of general formula (I): in which: R 1 is (C 6 or C 10 ) aryl or 6- to 10-membered heteroaryl, optionally substituted with 1, 2 or 3 substituents, the substituents being selected from (C 1 -C 10 ) alkyl, (C 1 -C 10 ) alkenyl, (C 1 -C 10 ) alkynyl, (C 1 -C 10 ) alkoxy, (C 1 -C 10 ) thioalkoxy, hydroxyl, (C 1 -C 10 ) hydroxyalkyl, halo, (C 1 -C 10 ) haloalkyl, amino, amido, (C 1 -C 10 ) alkylamino, (C 1 -C 10 ) alkylcarbonyloxy, (C 1 -C 10 ) alkoxycarbonyl, (C 1 -C 10 ) alkylcarbonyl, (C 1 -C 10 ) alkylthiocarbonyl, (C 1 -C 10 ) alkylsulfonylamino, aminosulfonyl, (C 1 -C 10 ) alkylsulfinyl, and (C 1 -C 10 ) alkylsulfonyl, R 2 and R 3 are linked together and such that, together with the intervening atoms, they form a 5, 6 or 7-membered aromatic or partially saturated ring containing one or more heteroatoms, which ring may be fused to further rings as part of a fused ring system, and which may bear 1, 2 or 3 substituents, which substituents independently have the same meaning as R 2′ on any or all of those rings, Q stands for (C 1 -C 8 ) alkyl that optionally includes a single double bond, which may be in the position adjacent to the carbonyl group, and is optionally interrupted by a C 6 aryl ring; (C 2 -C 6 ) alkenyl or (C 2 -C 6 ) alkynyl comprising one or more C═C bond or C≡C bond; V is OH, SH, SR, OR, NH 2 , NHR, NRR, NROH, NHOR, NROR where R may independently be hydrogen or (C 1 -C 6 ) alkyl, Y is N; Z is O, S, S(═O), S(═O) 2 , NR 4 , —N═, CR 4 R 5 , or —C(R 4 )═, where R 4 and R 5 independently have the same meaning as R 2′ ; and R 2′ is hydrogen, (C 1 -C 6 ) alkyl, substituted (C 1 -C 6 ) alkyl, or unsaturated (C 2 -C 6 ) alkenyl or alkynyl comprising one or more C═C bond or C≡C bonds, (C 6 or C 10 ) aryl or 6- or 10-membered heteroaryl, or a combination thereof to form a linked or fused ring system, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) thioalkoxy, hydroxyl, (C 1 -C 6 ) hydroxyalkyl, halo, (C 1 -C 6 ) haloalkyl, cyano, nitro, amino, amido, (C 1 -C 6 ) alkylamino, (C 1 -C 6 ) alkylcarbonyloxy, (C 1 -C 6 ) alkoxycarbonyl, (C 1 -C 6 ) alkylcarbonyl, (C 1 -C 10 ) alkylthiocarbonyl, (C 1 -C 6 ) alkylsulfonylamino, aminosulfonyl, (C 1 -C 6 ) alkylsulfinyl, or (C 1 -C 6 ) alkylsulfonyl; or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof.