Patent ID: 8809303

Claim:
A method of reducing actin cytoskeletal rearrangement or intercellular gap formation in a cell, the method comprising contacting the cell during cold ischemia with an effective amount of a compound of Formula (I): wherein: n is an integer from 1 to 6; X 1 is O or S; X 2 is O or S; R 1 , R 2 , and R 3 are independently C 2 -C 16 acyl, wherein at least one of R 1 , R 2 , and R 3 is C 2 -C 7 acyl; R 4 is selected from the group consisting of H, hydroxylalkyl, —C(═O)NH 2 , and —(CH 2 ) m C(═O)OH, wherein m is an integer from 0 to 2; and R 5 , R 6 , and R 7 are independently C 10 -C 12 alkyl, or a pharmaceutically acceptable salt thereof; wherein reducing actin cytoskeletal rearrangement or intercellular gap formation comprises reducing actin cytoskeletal rearrangement or intercellular gap formation during reperfusion subsequent to the cold ischemia.