Patent ID: 8551700

Claim:
A method for diagnosing malignant pleural mesothelioma (MPM) or a subtype of MPM in a subject suspected of having MPM or the subtype of MPM, comprising providing a set of two or more genes, wherein the set comprises at least one gene that is upregulated in subjects who have MPM or a subtype of MPM than in subjects who have no MPM or the subtype of MPM and at least one gene that is downregulated in subjects that have MPM or the subtype of MPM than in subjects who have no MPM or the subtype of MPM, wherein the set of two or more genes are selected from the group consisting of the genes set forth in Table 1, Table 2, Table 4, and Table 10, ribosomal protein genes set forth in Tables 6 and 7, cytoskeletal and ECM-related genes set forth in Tables 6 and 7, SEQ ID NOs:9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, and 77, measuring the expression levels of the set of two or more genes in a tissue sample of the subject, calculating at least one ratio of the expression level of the at least one upregulated gene to the expression level of the at least one downregulated gene, and determining whether the subject has MPM or the subtype of MPM based on the at least one ratio.