Patent ID: 7994184

Claim:
A pharmaceutical formulation that promotes cell death in a p53 naive cell, said formulation comprising a pharmacologically acceptable excipient and a therapeutically effective amount of a compound having the formula: wherein: R 1 and R 4 are independently selected from the group consisting of an amino group, a cyano group, a nitro group, a carboxyl group, halo, hydroxyl, SO 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-8 alkoxyl, C 1-11 alkoxyalkyl, C 1-6 alkylamino, and C 1-6 aminoalkyl; R 2 and R 3 are independently selected from the group consisting of CH and N; R 5 is CH 2 or O; R 6 and R 7 are independently; R 8 is selected from the group consisting of NO 2 , OH, and COOH; and R 9 is selected from the group consisting of H, CH 3 ; or a pharmaceutically acceptable ester or salt thereof; wherein said formulation is sterile; and wherein said formulation is an injectable, an aerosol formulation, or an implantable sustained-release formulation.