Patent ID: 6960435

Claim:
An isolated polynucleotide selected from the group consisting of: (a) a polynucleotide that comprises a nucleotide sequence as set forth in SEQ ID NO:3, 5, 7 or 9, (b) a polynucleotide that encodes a polypeptide having an amino acid sequence as set forth in SEQ ID NO: 4, 6, 8 or 10, (c) a polynucleotide that hybridizes under stringent conditions to a polynucleotide comprising a nucleotide sequence as set forth in SEQ ID NO: 3, 5, 7 or 9, wherein the stringent conditions comprise washing in 0.1×SSC and 0.1% SDS at 65° C., and (d) a polynucleotide that shows at least 95% identity to a nucleotide sequence as set forth in SEQ ID NO: 3, 5, 7 or 9, or a fragment of said polynucleotide; wherein said polynucleotide or said polynucleotide fragment encodes a polypeptide (a) which suppresses or promotes the aggregation of amyloid or (b) which is an immunogenic polypeptide.