Patent ID: 7026318

Claim:
A compound of the general formula (VI): wherein R 1 is —(L 1 )-(acidic group) wherein L 1 is a group represented by the formula: wherein M is —CH 2 —, —O—, —N(R 30 )—, or —S—; R 28 and R 29 are each independently hydrogen atom, C1–C10 alkyl, aryl, aralkyl, carboxy, or halogen, or a group represented by the formula: wherein R 13 and R 14 are each independently hydrogen atom, C1–C10 alkyl, C1–C10 aralkyl, carboxy, alkyloxycarbonyl, or halogen; R 3 and R 4 are each independently selected from hydrogen atom, (h) C1–C10 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, C7–C12 aralkyl, C7–C12 alkaryl, C3–C8 cycloalkyl, phenyl, tolyl, xylyl, biphenylyl, C1–C10 alkyloxy, C1–C6 alkyloxy C1–C6 alkyl, C1–C6 alkyloxy C1–C6 alkyloxy, C1–C6 alkylcarbonyl, C1–C6 alkylcarbonylamino, C1–C6 alkyloxyamino, C1–C6 alkyloxyaminocarbonyl, mono or di C1–C6 alkylamino, C1–C10 alkylthio, C1–C6 alkylthiocarbonyl, C1–C6 alkylsulfinyl, C1–C6 alkylsulfonyl, C2–C6 haloalkyloxy, C1–C6 haloalkylsulfonyl, C1–C10 haloalkyl, C1–C6 hydroxyalkyl, C1–C6 alkyloxycarbonyl, —(CH 2 ) 1-8 —O—(C1–C6 alkyl), benzyloxy, aryloxy, arylthio, —(CONHSO 2 R 39 ) wherein R 39 is C1–C6 alkyl or aryl, —CHO, amino, amidino, halogen, carbamyl, carboxyl, carbalkoxy, —(CH 2 ) 1-8 —COOH, cyano, cyanoguanidino, guanidino, hydrazide, hydrazino, hydroxy, hydroxyamino, nitro, phosphono, —SO 3 H, thioacetal, thiocarbonyl, a carbocyclic group, a heterocyclic group or (j) a carbocyclic or heterocyclic group substituted with a group defined in (h); R 5 is (f) C1–C20 alkyl, C2–C20 alkenyl, C2–C20 alkynyl, a carbocyclic group, or a heterocyclic group or (g) a group defined in (f) each substituted independently with at least one group selected from C1–C10 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, C7–C 12 aralkyl, C7–C12 alkaryl, C3–C8 cycloalkyl, phenyl, tolyl, xylyl, biphenylyl, C1–C10 alkyloxy, C1–C6 alkyloxy C1–C6 alkyl, C1–C6 alkyloxy C1–C6 alkyloxy, C1–C6 alkylcarbonyl, C1–C6 alkylcarbonylamino, C1–C6 alkyloxyamino, C1–C6 alkyloxyaminocarbonyl, mono or di C1–C6 alkylamino, C1–C10 alkylthio, C1–C6 alkylthiocarbonyl, C1–C6 alkylsulfinyl, C1–C6 alkylsulfonyl, C2–C6 haloalkyloxy, C1–C6 haloalkylsulfonyl, C1–C10 haloalkyl, C1–C6 hydroxyalkyl, C1–C6 alkyloxycarbonyl, —(CH 2 ) 1-8 —O—(C1–C6 alkyl), benzyloxy, aryloxy, arylthio, —(CONHSO 2 R 40 ) wherein R 40 is C1–C6 alkyl or aryl, —CHO, amino, amidino, halogen, carbamyl, carboxyl, carbalkoxy, —(CH 2 ) 1-8 —COOH, cyano, cyanoguanidino, guanidino, hydrazide, hydrazino, hydroxy, hydroxyamino, nitro, phosphono, —SO 3 H, thioacetal, thiocarbonyl, a carbocyclic group or a heterocyclic group; R 6 is optionally substituted C4–C8 alkyl, C3–C8 cycloalkyl C1–C4 alkyl, or aryl C1–C4 alkyl; R A is represented by the formula: wherein R 9 and R 10 are each independently hydrogen atom, C1–C3 alkyl, or halogen; X and Y are each independently oxygen atom or sulfur atom; and Z is —NH 2 or —NHNH 2 ; a C1–C6 alkyl, acyloxyalkyl, or alkyloxycarbonyloxyalkyl ester thereof, or a pharmaceutically acceptable salt thereof.