Patent ID: 8163724

Claim:
A compound of formula wherein X 1 , X 2 , X 3 , X 4 and X 5 each independently represent CH or a nitrogen atom, provided that no more than two of X 1 , X 2 , X 3 , X 4 and X 5 may simultaneously represent a nitrogen atom; n and p each independently represent 0 or 1; R 1 represents a halogen atom or a methyl or a methoxy group; R 2 represents a halogen atom, —C(O)OCH 3 , —C(O)—S—CH 2 CN, —C(O)—S—CH 3 , —C(O)-heterocyclyl, —SO 2 CH 3 , a C 2 -C 6 alkenyl group, or a methyl group optionally substituted by halogen, hydroxyl, methoxy, —OCH 2 CH═CH 2 or —NR 7 R 8 ; R 3a represents a hydrogen atom or methyl group and R 3b represents a hydrogen or fluorine atom; R 4 represents —C(O)—S—C(O)N(CH 3 ) 2 or, —C(O)—Y—CH(R 11 )—R 9 ; R 5 represents hydroxyl, —OCH 2 SCH 3 , —O—C(O)—R 10 , —O—C(O)—NH—R 10 , —O—C(O)—O—R 10 or —O—C(O)—S—R 10 ; R 6 represents a hydrogen or a halogen atom or a methyl group, and when R 5 is other than a hydroxyl group, R 6 may additionally represent a hydroxyl group; R 7 and R 8 each independently represent a hydrogen atom, or a C 1 -C 3 alkyl or a C 1 -C 3 hydroxyalkyl group, or R 7 and R 8 together with the nitrogen atom to which they are attached form a 3- to 8-membered saturated or partially saturated heterocyclic ring optionally containing a further ring heterogroup selected from nitrogen, S(O) m and oxygen, the heterocyclic ring being optionally substituted by at least one substituent selected from hydroxyl, C 1 -C 3 alkyl and C 1 -C 3 hydroxyalkyl; m is 0, 1 or 2; Y represents an oxygen or sulphur atom or a group>NH; R 9 represents hydrogen, halogen, cyano, —S—CN, —C(O)N(R 12 ) 2 , C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkylcarbonyl (optionally substituted by —OC(O)CH 3 ), C 1 -C 6 alkylcarbonyloxy, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, —C(O)—S—C 1 -C 6 alkyl, —C(═CH 2 )—O—CH 2 OCH 3 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 3 -C 7 cycloalkyl, the latter four groups being optionally substituted by one or more substituents independently selected from halogen, hydroxyl, cyano, hydroxymethyl, C 1 -C 4 alkoxy and C 1 -C 4 alkylcarbonyloxy; R 10 represents C 1 -C 6 alkyl (optionally substituted by halogen, C 1 -C 4 alkoxy, C 1 -C 4 alkylcarbonyloxy or C 3 -C 7 cycloalkyl) or a 3- to 10-membered saturated or unsaturated carbocyclic or heterocyclic ring system which ring system may be optionally substituted by at least one substituent selected from halogen, carboxyl, hydroxyl, oxo, nitro, cyano, mercapto, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylsulphinyl, C 1 -C 6 alkylsulphonyl, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkylcarbonyloxy, C 1 -C 6 alkoxycarbonyl, amino (—NH 2 ), carboxamido (—CONH 2 ), (mono) C 1 -C 6 alkylamino, (di) C 1 -C 6 alkylamino and phenyl; R 11 represents a hydrogen atom or a methyl group; and each R 12 independently represents a hydrogen atom or a methyl group; or a pharmaceutically acceptable salt thereof.