Patent ID: 7741024

Claim:
A method of obtaining an antibody to a viral envelope glycoprotein, the method comprising: (a) screening a library of antibodies with an immunogenic proteoliposome comprising: (i) a spherical or elliptoid shape having a ligand to a viral envelope glycoprotein anchored to the shape, wherein said shape's surface is surrounded by a lipid bilayer; (ii) said envelope glycoprotein bound to said ligand, wherein said envelope glycoprotein's transmembrane domain(s) are in said lipid bilayer and said envelope glycoprotein comprises a multimer containing two, three, or four monomeric units and has a wild-type conformation; and (iii) an attractant coating said shape's surface, wherein said lipid bilayer comprises a moiety that binds to the attractant forming a lipid bilayer surrounded shape; and (b) selecting antibodies in the library that bind to said proteoliposome.