Patent ID: 8062635

Claim:
A bispecific antibody that recognizes blood coagulation factor IX and/or activated blood coagulation factor IX and blood coagulation factor X, wherein said antibody comprises complementarity determining regions (CDRs) comprising (A) the amino acid sequences of anti-blood coagulation factor IX/IXa antibody H chain CDRs of the following (a1) or (a2) and L chain CDRs of the following (b1) or (b2); and (B) the amino acid sequences of anti-blood coagulation factor X antibody H chain CDRs of any one of the following (c1) to (c9) and L chain CDRs of the following (d1) or (d2): (a1) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 14, 15, and 16, respectively; (a2) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 18, 19, and 20, respectively; (b1) L chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 206, 207, and 208, respectively; (b2) L chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 214, 215, and 216, respectively; (c1) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 22, 23, and 24, respectively; (c2) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 26, 27, and 28, respectively; (c3) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 30, 31, and 32, respectively; (c4) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 34, 35, and 36, respectively; (c5) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 38, 39, and 40, respectively; (c6) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 42, 43, and 44, respectively; (c7) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 46, 47, and 48, respectively; (c8) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 50, 51, and 52, respectively; (c9) H chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 54, 55, and 56, respectively; (d1) L chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 210, 211, and 212, respectively; (d2) L chain CDR 1, 2, and 3 amino acid sequences described in SEQ ID NOs: 218, 219, and 220, respectively, wherein the antibody functionally substitutes for blood coagulation factor VIII and/or activated blood coagulation factor VIII.