Patent ID: 7964706

Claim:
An isolated antibody or an antigen-binding fragment thereof that specifically binds a human HMGB1 polypeptide or antigenic fragment thereof comprising: a) a light chain variable region having the 3 CDRs of the light chain of the antibody S6, SEQ ID NO:9, and a heavy chain variable region, wherein the heavy chain variable region comprises 3 CDRs; or b) a heavy chain variable region having the 3 CDRs of the light chain of the antibody S6, SEQ ID NO:11, and a light chain variable, wherein the light chain variable region comprises 3 CDRs; or c) a light chain variable region having the 3 CDRs of the light chain of the antibody S6, SEQ ID NO:9, and a heavy chain variable region having the 3 CDRs of the heavy chain of the antibody S6, SEQ ID NO:11.