Patent ID: 8802153

Claim:
A targeted particle comprising a polymer conjugated to a surfactant, hydrophilic polymer or lipid, Wherein the particle is a nanoparticle having bound thereto a plurality of small molecule targeting moieties that specifically bind to the Zn 2+ NAAG/PSMA binding pocket within prostate specific membrane antigen (PSMA) selected from the group consisting of 2-PMPA, GP15232, VA-033 2 MPPA, 2-MPPA, thiol and indole thiol based PSMA inhibitors, 3-(2-mercaptoethyl)-1H-indole-2-carboxylic acid derivative PSMA inhibitors, hydroxamate derivative PSMA inhibitors, PDBA-based PSMA inhibitors, and urea-based PSMA inhibitors, and having encapsulated or dispersed therein a taxane.