Patent ID: 7101886

Claim:
A compound of the formula 1 wherein M is R 1 is 1,2-benzisothiazoyl, 1,2-benzisothiazoyl-1-oxide, 1,2-benzisothiazoyl-1-dioxide, or 1,2-benzisoxazolyl, and wherein said R 1 can optionally be substituted by one to four substituents, independently selected from halo, cyano, nitro, (C 1 –C 6 )alkyl optionally substituted with from one to three fluorine atoms and (C 1 –C 6 )alkoxy optionally substituted with from one to three fluorine atoms, and wherein the point of attachment of R 1 to the piperazine nitrogen of formula 1 is a carbon atom of the heterocyclic ring of R 1 ; A is —(CH 2 ) n CH 2 —, wherein n is an integer from one to three; U is carbon or nitrogen; m is 1 or 2; each of X 1 , X 2 and X 3 is, independently, hydrogen, halo, (C 1 –C 6 )alkyl optionally substituted with from one to three fluorine atoms and (C 1 –C 6 )alkoxy optionally substituted with from one to three fluorine atoms; R 2 is hydrogen, (C 1 –C 6 )alkyl, aryl(C 1 –C 6 )alkyl, (C 1 –C 6 )alkenyl, heteroaryl, or heteroaryl(C 1 –C 6 )alkyl, and where the aryl and heteroaryl moieties of the foregoing R 2 groups may be optionally substituted with one or two substituents independently selected from halo, (C 1 –C 6 )alkyl optionally substituted with from one to three fluorine atoms and (C 1 –C 6 )alkoxy optionally substituted with from one to three fluorine atoms; W is —C(O)—, —C(O)O—, —C(O)NH—, —S(O) 2 —, or —S(O 2 )N(R 4 )—, wherein the hyphen (“-”) to the left of each of the foregoing moieties represents the bond to NR 2 in structural formula 1, and the hyphen (“-”) to the right of each of the foregoing moieties represents the bond to R 3 in structural formula 1; and R 3 is selected, independently, from (C 1 –C 6 )alkyl, aryl(C 1 –C 6 )alkyl, heteroaryl, and heteroaryl(C 1 –C 6 )alkyl, wherein the aryl and heteroaryl moieties of the foregoing R 3 and R 4 groups can be optionally be substituted with one or two substituents independently selected from halo, (C 1 –C 6 )alkyl optionally substituted with from one to three fluorine atoms and (C 1 –C 6 )alkoxy optionally substituted with from one to three fluorine atoms; R 4 is selected, independently, from (C 1 –C 6 )alkyl, aryl(C 1 –C 6 )alkyl, (C 1 –C 6 )alkenyl, heteroaryl, and heteroaryl(C 1 –C 6 )alkyl, wherein the aryl and heteroaryl moieties of the foregoing R 3 and R 4 groups can be optionally be substituted with one or two substituents independently selected from halo, (C 1 –C 6 )alkyl optionally substituted with from one to three fluorine atoms and (C 1 –C 6 )alkoxy optionally substituted with from one to three fluorine atoms; or a pharmaceutically acceptable salt thereof.