Patent ID: 8328775

Claim:
A metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop comprising: (a) a bottle body having walls defining an internal volume, wherein the walls comprise a bottom wall and side walls, wherein the side walls comprise a flexible portion to decrease the internal volume by a fixed volume, wherein the flexible portion is a flexible notch; (b) a plunger with a fixed stroke between a minimum depth position and a maximum depth position for depressing the flexible notch; (c) a nozzle tip formed around an opening, said nozzle tip having an internal and/or outer diameter in a range of from 0.6 mm to 1.2 mm; and (d) an external cover which surrounds the bottle body and houses the plunger, wherein the flexible notch area is controllably depressed by the plunger by a distance of about 0.8 mm to about 2 mm in order to deliver a predetermined volume of liquid from the bottle to the opening of the nozzle tip.