Patent ID: 8604015

Claim:
A compound of formula (I): wherein: X is O or S; X′ is O or S; Y is NH or absent; R 1 is aryl, heteroaryl, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, or a group of formula (a) or (b): wherein R 3 and R 4 are the same or different and may be independently H or are selected from the group consisting of (C 3 -C 8 )cycloalkyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, and heteroaryl(C 1 -C 6 )alkyl, each which may be optionally substituted by one or more substituents selected from the group consisting of a halogen atom, —OH, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkoxy, oxo (═O), —SH, —NO 2 , —CN, —CONH 2 , —COOH, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkylsulfanyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfonyl and (C 1 -C 6 )alkyl or, when R 3 and R 4 are both independently aryl or heteroaryl they may be linked to each other through a (CH 2 ), group wherein r=0, 1, or 2, to form a tricyclic ring system wherein any of the methylene (CH 2 ) r groups may be optionally replaced by a heteroatom or heteroaromatic group selected from O, S, N and NH, and with the proviso that R 3 and R 4 are not simultaneously H; R 2 is a group of formula (c) or (d): wherein m=1, 2 or 3; n=1, 2 or 3; A − is a physiologically acceptable anion; R 5 is a group of formula (e): —(CH 2 ) p —P—(CH 2 ) q —W (e) wherein p is 0 or an integer from 1 to 4; q is 0 or an integer from 1 to 4; P is absent or is selected from the group consisting of —O—, —S—, —S(O)—, —S(O 2 )—, —C(O)—, —CO(O)—, —N(R 6 )—, —CH═CH—, —N(R 6 )(SO 2 )—, —N(R 6 )CO(O)—, —N(R 6 )C(O)—, —SO 2 N(R 6 )—, —CO(O)N(R 6 )— and —C(O)N(R 6 )—; W is H or is selected from the group consisting of (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted by one or more substituents selected from the group consisting of a halogen atom, —OH, oxo (═O), —SH, —NO 2 , —N(R 6 ) 2 , —CN, —CON(R 6 ) 2 , —COOH, —NHCOR 6 , CO 2 R 6 , (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkylsulfanyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, aryl, and heteroaryl; R 6 is, independently in each occurrence, H or is selected from the group consisting of (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )alkenyl, (C 3 -C 8 )cycloalkyl, heteroaryl, and aryl, each of which is optionally substituted by one or more substituents selected from the group consisting of halogen atoms, —OH, oxo (═O), —SH, —NO 2 , —CN, —CONH 2 , —COOH, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkylsulfanyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfonyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy; or a pharmaceutically acceptable salt thereof.