Patent ID: 7196112

Claim:
A compound of formula: or a stereoisomer thereof wherein Ar 1 is a substituted or unsubstituted carbocyclic aryl group, L 1 is a C 1 –C 4 alkylene group, R 1 is hydrogen or a moiety having the formula —R 5 -L 2 -(O-L 3 -) n OR 6 , R 2 is a C 1 –C 10 alkyl, aminoalkyl, thioalkyl, arylalkyl, or hydroxyalkyl group, or a moiety having the formula —R 5 -L 2 -(O-L 3 -) n OR 6 , R 3 is hydrogen or a C 1 –C 6 alkyl group, R 4 is an optionally substituted aralkyl group, and at least one of R 1 or R 2 includes a moiety having the formula —R 5 -L 2 -(O-L 3 -) n OR 6 , wherein: each R 5 , independently, is a bond, —C(O)—, —C(O)—O—, —O—C(O)—, —S(O) p —O—, —O—S(O) p —, —C(O)—N(R a )—, —O—C(O)—N(R a )—, —N(R a )—C(O)—, —N(R a )—C(O)—O—, —O—S(O) p —N(R a )—, —N(R a )—S(O) p —O—, —N(R a )—C(O)—N(R b )—, —N(R a )—S(O) p —N(R b )—, —C(O)—N(R a )—S(O) p —, —S(O) p —N(R a )—C(O)—, —C(O)—N(R a )—S(O) p —N(R b )—, —C(O)—O—S(O) p —N(R a )—, —N(R a )—S(O) p —N(R b )—C(O)—, —N(R a )—S(O) p —O—C(O)—, —S(O) p —N(R a )—, —N(R a )—S(O) p —, —N(R a )—, —S(O) p —, —O—, —S—, or —(C(R a )(R b )) q —, wherein each of R a and R b , independently, is hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, or aralkyl, p is 1 or 2; and q is 1, 2, 3, or 4; each L 2 , independently, is a bond, aryl, cycloalkyl, or a C 1–C 20 alkylene group, wherein L 2 is optionally interrupted or terminated by one or more of —C(O)—, —C(O)—O—, —O—C(O)—, —S(O) p —O—, —O—S(O) p —, —C(O)—N(R a )—, —C(O)—N(R a )—, —N(R a )—C(O)—, —N(R a )—C(O)—O—, —O—S(O) p —N(R a )—, —N(R a )—S(O) p —O—, —N(R a )—C(O)—N(R b )—, —N(R a )—S(O) p —N(R b )—, —C(O)—N(R a )—S(O) p —, —S(O) p —N(R a )—C(O)—, —C(O)—N(R a )—S(O) p —N(R b )—, —C(O)—O—S(O) p —N(R a )—, —N(R a )—S(O) p —N(R b )—C(O)—, —N(R a )—S(O) p —O—C(O)—, —S(O) p —N(R a )—, —N(R a )—S(O) p —, —N(R a )—, —S(O) p —, —O—, —S—, or —(C(R a )(R b )) q —, wherein each of R a and R b , independently, is hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, or aralkyl, p is 1 or 2; and q is 1, 2, 3, or 4; each L 3 , independently, is a C 1 –C 6 alkylene group; each R 6 , independently, is hydrogen, a C 1 –C 6 alkyl group, a carbocyclic aryl group, a moiety having the formula: or a moiety having the formula: wherein R 2 is a C 1 –C 10 alkyl, aminoalkyl, thioalkyl, arylalkyl, or hydroxyalkyl group; and n is an integer chosen such that the compound has a molecular weight between 400 and 70,000; provided that when Ar 1 is phenyl, L 1 is —CH 2 CH 2 —, R 2 is 2-methylpropyl, R 3 is methyl, and R 4 is 4-((N′-2-methylphenyl)ureido)benzyl, R 1 is not —N(H)—C(O)—CH 2 CH 2 —(OCH 2 CH 2 ) n —OCH 3 where n is selected such that R 1 has a molecular weight of approximately 20,000, and R 1 is not —N(H)—C(O)—(CH 2 ) 5 —N(H)—C(O)—CH 2 CH 2 —(OCH 2 CH 2 ) n —OCH 3 , where n is selected such that R 1 has a molecular weight of approximately 20,000, 30,000 or 50,000.