Patent ID: 7968557

Claim:
A compound selected from Formula Ia and Id: in which: n is selected from 0, 1 and 2; W is selected from —NR 4 —, —S—, —O—, —S(O)— and —S(O) 2 —; wherein R 4 is selected from hydrogen and C 1-6 alkyl; R 1 is selected from C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 1 is optionally substituted by 1 to 3 groups independently selected from halo, nitro, cyano, C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XNR 5 R 5 , —XNR 5 XNR 5 R 5 , —XNR 5 XOR 5 , —XOR 5 , —XSR 5 , —XS(O)R 5 , —XS(O) 2 R 5 , —XC(O)NR 5 R 5 , —XOXR 6 and —XC(O)R 6 ; wherein X is a bond or C 1-6 alkylene; R 5 is selected from hydrogen, C 1-6 alkyl and C 3-12 cycloalkyl-C 0-4 alkyl; and R 6 is selected from C 3-8 heterocycloalkyl-C 0-4 alkyl and C 5-10 heteroaryl -C 0-4 alkyl optionally substituted by 1 to 3 groups selected from C 1-6 alkyl and —C(O)OH; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl substituent of R 1 is further optionally substituted by 1 to 5 groups independently selected from C 1-6 alkyl and C 1-6 alkoxy; R 2 is selected from C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl -C 0-4 alkyl; wherein any arylalkyl, heteroarylalkyl, cycloalkylalkyl of R 2 is optionally substituted by 1 to 3 groups independently selected from halo, nitro, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 3-8 heteroaryl C 0-4 alkyl, —XNR 5 R 5 , —XOR 5 , —XSR 5 , —XS(O)R 5 , —XS(O) 2 R 5 , —XSNR 5 R 5 , —XS(O)NR 5 R 5 , —XS(O) 2 NR 5 R 5 , —XC(O)OR 5 , —XOC(O)R 5 , —XC(O)R 5 , —XC(O)NR 5 XNR 5 R 5 , —XC(O)NR 5 R 5 , —XC(O)NR 5 XC(O)OR 5 , —XC(O)NR 5 XNR 5 C(O)R 5 , —XC(O)NR 5 XNR 5 C(O)OR 5 , —XC(O)NR 5 XOR 5 , —XC(O)N(XOR 5 ) 2 , —XNR 5 C(O)R 5 , —XC(O)NR 5 R 6 , —XC(O)R 6 , —XR 7 , —XC(O)R 7 , —XR 6 and —XC(O)NR 5 XR 7 ; wherein X is a bond or C 1-6 alkylene; and R 5 is selected from hydrogen, C 1-6 alkyl and C 3-12 cycloalkyl-C 0-4 alkyl; R 6 is selected from C 3-8 heterocycloalkyl-C 0-4 alkyl and C 5-10 heteroaryl-C 0-4 alkyl optionally substituted by 1 to 3 groups selected from C 1-6 alkyl and —C(O)OH; and R 7 is selected from halo and cyano; R 3 is selected from halo, hydroxy, —XSR 5 , —XS(O)R 5 , —XS(O) 2 R 5 , —XC(O)R 5 and —XC(O)OR 5 ; wherein X is a bond or C 1-6 alkylene; and R 5 is selected from hydrogen, C 1-6 alkyl and C 3-12 cycloalkyl-C 0-4 alkyl; or a pharmaceutically acceptable salt thereof.