Patent ID: 7579332

Claim:
A compound having the formula: wherein: X 1 is selected from the group consisting of: X 2 is selected from the group consisting of O, NR and S; Y 1 is independently O, S, NR, or N—NR 2 ; Y 2 is independently O, NR, N—NR 2 , —S(O) M2 —, or —S(O) M2 —S(O) M2 —; Y 3 and Z are independently selected from the group consisting of H, OH, OR, NR 2 , CN, NO 2 , F, Cl, Br, and I; R X is independently H, W 3 , a protecting group, or the formula: M1a, M1c, and M1d are independently 0 or 1; M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12; R y is independently H, W 3 , or a protecting group; M2 is 0,1 or 2; R 1 , R 2 , R 4 , R 6 , R 7 , and R 8 are independently selected from the group consisting of H, F, Cl, Br, I, OH, —C(═Y 1 )R, —C(═Y 1 )OR, —C(═Y 1 )N(R) 2 , —N(R) 2 , —SR, —S(O)R, —S(O) 2 R, —S(O)(OR x ), —S(O) 2 (OR x ), —OC(═Y 1 )OR x , —OC(═Y 1 )OR x , —OC(═Y 1 )(N(R x ) 2 ), —SC(═Y 1 )R x , —SC(═Y 1 )OR x , —SC(═Y 1 )(N(R x ) 2 ), —N(R x )C(═Y 1 )OR x , —N(R x )C(═Y 1 )OR x , —N(R x )C(═Y 1 )N(R x ) 2 , amino (—NH 2 ), alkylamino, dialkylamino, C 1 -C 8 alkyl, C 1 -C 8 alkylsulfonate, C 1 -C 8 alkylamino, alkylsulfone (—SO 2 R), arylsulfone (—SO 2 Ar), arylsulfoxide (—SOAr), arylthio (—SAr), sulfonamide (—SO 2 NR 2 ), alkylsulfoxide (—SOR), ester (—C(═O)OR), amido (—C(═O)NR 2 ), nitrile (—CN), azido (—N 3 ), nitro (—NO 2 ), C 1 -C 8 alkoxy (—OR), C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 2 -C 8 alkenyl, C 2 -C 8 substituted alkenyl, C 2 -C 8 alkynyl, C 2 -C 8 substituted alkynyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heteroaryl, C 2 -C 20 substituted heteroaryl, polyethyleneoxy, and W 3 ; or when taken together, two of R 1 , R 2 , R 4 , R 6 , R 7 , and R 8 form a carbocyclic ring of 3 to 7 carbon atoms; R 3 is hydroxyalkyl; R 5 is C 1 -C 8 substituted alkyl; R is selected from the group consisting of C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 2 -C 8 alkenyl, C 2 -C 8 substituted alkenyl, C 2 -C 8 alkynyl, C 2 -C 8 substituted alkynyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heteroaryl, and C 2 -C 20 substituted heteroaryl; W 3 is W 4 or W 5 ; W 4 is R, —C(Y 1 )R, —C(Y 1 )W 5 , —SO 2 R, or —SO 2 W 5 ; W 5 is carbocycle or heterocycle wherein W 5 is independently substituted with 0 to 3 R groups; and NUCLEOBASE is selected from the group consisting of adenine, guanine, 2-aminopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, hypoxanthine, isoguanine, 6-thioguanine, O 6 -methylguanine, and N 6 -methyladenine or a pharmaceutically acceptable salt thereof.