Patent ID: 7288651

Claim:
A method for making amidophenyl-sulfonylamino-quinoxalines comprising the steps of sulfonylating compound C1: with compound D1: to produce a compound of formula C3: wherein R a is independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, phenyl, furanyl, thienyl, benzyl, pyrrol-1-yl, —OH, —OC 1-6 alkyl, —OC 3-6 cycloalkyl, —Ophenyl, —Obenzyl, —SH, —SC 1-6 alkyl, —SC 3-6 cycloalkyl, —Sphenyl, —Sbenzyl, —CN, —NO 2 , —N(R y )R z (wherein R y and R z are independently selected from H, C 1-4 alkyl or C 1-6 -cycloalkylC 1-4 alkyl), —(C═O)C 1-4 alkyl, —SCF 3 , halo, —CF 3 , —OCF 3 , and —COOC 1-4 alkyl, or, alternatively, two adjacent R a , may be taken together with the carbons of attachment to form a fused ring and selected from the group consisting of phenyl, pyridyl and pyrimidinyl; or alternatively, R 2 and one of R a can be taken together to be —CH 2 — or >C═O and to form a fused ring to the phenyl; R b is, independently, selected from the group consisting of C 1-4 alkyl and halogen; and enantiomers, diastereomers, hydrates, and pharmaceutically acceptable salts thereof.