Patent ID: 8039211

Claim:
A method of determining whether a human subject is at risk for drug-induced hepatic toxicity, comprising the steps of: (a) detecting the MRP-1 genotype at a position corresponding to position 11 of SEQ ID NO:171 in the human subject; and (b) (i) based on the detection of a homozygous (C/C) at the position corresponding to position 11 of SEQ ID NO:171 in the human subject determining that the human subject is at risk for drug-induced hepatic toxicity; or (ii) based on the detection of a heterozygous (T/C) or homozygous (T/T) at the position corresponding to position 11 of SEQ ID NO:171 in the human subject determining that the human subject is at decreased risk for drug-induced hepatic toxicity relative to the detection of a homozygous (C/C) at said position.