Patent ID: 8691820

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Y 1 -Y 4 are independently O, S, N, NR 8 or CR 21 ; R 21 is independently selected from hydrogen, hydroxy, substituted hydroxy, amino, substituted amino, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylamino, substituted or unsubstituted dialkylamino, substituted or unsubstituted thiol, CF 3 , CN, NO 2 , N 3 , substituted carbonyl, sulfonyl, acyl, aliphatic, or substituted aliphatic; Y 5 is C or N; M is absent or O; B 1 is N(R 8 ); B 2 is CO; B 3 is absent, O, S, SO, SO 2 , N(R 8 ), CO, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; B 4 is absent, O, S, SO, SO 2 , N(R 8 ), CO, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; B 5 is absent, O, S, SO, SO 2 , N(R 8 ), CO, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; B 6 is absent, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; Z is O, S, S(O), SO 2 , SO 2 NH, NR 8 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C(O) or C(O)NH; R 8 is hydrogen, acyl, aliphatic or substituted aliphatic; R 1 is substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aryl, substituted or unsubstituted aryl-C 1 -C 6 -alkyl, or substituted or unsubstituted heteroaryl-C 1 -C 6 -alkyl, provided that R 1 is not substituted or unsubstituted 2-aminophenyl; R 2 is hydrogen; or R 1 and R 2 , together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl group which is optionally fused with a cycloalkyl, aryl or heterocyclic group; R 3 is absent, or R 3 and R 2 , or R 3 and R 1 , together with the intervening atoms, form a heterocyclic group which is optionally fused with a cycloalkyl, aryl or heterocyclic group; and R 5 is hydrogen, aliphatic or substituted aliphatic.