Patent ID: 8487009

Claim:
A pharmaceutical composition comprising a compound of formula Ib: wherein R 1 is isopropyl; R 2 is selected from a group consisting of a) H, b) alkyl, alkenyl, alkynyl, aryl, aralkyl, 4-methylbenzyl, 3-fluorobenzyl, or 3,5-difluorobenzyl, c) COOR 6 , d) NR 7 R 8 , e) S(O) 2 NR 7 R 8 , f) COR 9 , g) OR 10 , and h) S(O) n R 11 , n=0−2, R 3 is selected from a group consisting of a) H, b) alkyl, alkenyl, alkynyl, aryl, aralkyl, 4-methylbenzyl, 3-fluorobenzyl, or 3,5-difluorobenzyl, c) halo, e) NR 7 R 8 , f) S(O) 2 NR 7 R 8 , g) COR 9 , h) OR 10 , and i) S(O) n R 11 , n=0−2, R 4 and R 5 are independently each selected from the group consisting of a) H, b) alkyl, cycloalkyl, aryl or aralkyl, or c) acyl; R 6 is selected from a) alkyl, cycloalkyl, aryl or aralkyl R 7 and R 8 are independently selected from a group consisting of a) H, or b) alkyl, cycloalkyl, aryl or aralkyl; R 9 is selected from a) H, or b) alkyl, cycloalkyl, aryl, or aralkyl, R 10 is selected from a) H, b) alkyl, cycloalkyl, aryl, or aralkyl, or c) acyl; R 11 is selected from a) H, or b) alkyl, cycloalkyl, aryl or aralkyl; Ar is an unsubstituted phenyl, or a phenyl monosubstituted or multisubstituted independently with unsubstituted or substituted alkyl, alkenyl, alkynyl, aryl or aralkyl, halogen, CN, COOR 6 , NR 7 R 8 , S(O) 2 NR 7 R 8 , COR 9 , OR 10 , or S(O) n R 11 wherein n=0−2; provided that R 2 and R 3 cannot be H simultaneously, the configuration of the double bond is Z or E, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or excipient.