Patent ID: 8399078

Claim:
A flexible, at least partially transparent container for storage of a liquid pharmaceutical composition in a water-tight chamber, the container comprising: a liquid pharmaceutical composition comprising, an active ingredient and at least one preservative selected from the group consisting of phenol, m-cresol, and benzyl alcohol; a flexible wall material, that forms the water-tight chamber, comprising at least two layers, an inner layer consisting of polyethylene (PE) or polypropylene (PP) in intimate contact with said liquid pharmaceutical composition, and an outer layer consisting of polychlorotrifluoroethylene (PCTFE), said inner and outer layers being joined intimately together by a tie layer, wherein when said chamber is filled with water and stored at a temperature of about 5° C. for 24 months, less than 10% (weight/weight) of the content of water diffuses out from the container; and when said chamber is filled with water containing about 1.8 mg/mL (19 mM) of phenol and stored at a temperature of about 5° C. for 24 months, the change in the concentration of phenol in the liquid is less than about 10% (weight/weight), wherein the outer layer alone fulfills the requirement that when said chamber is filled with water and stored at a temperature of about 5° C. for 24 months less than 10% (weight/weight) of the content of water diffuses out from the container.