Patent ID: 8198298

Claim:
A method for inhibiting one or more protein kinases selected from the group consisting of ACK1, AKT, JAK2, MET, MST4, NEK6, RET and IGF-1R which comprises contacting said kinase with an effective amount of a pyrrolo[2,3-b]pyridine represented by formula (I) wherein R is —R a , —COR a , —CONR a R b , —SO 2 R a or —COOR a ; R 1 is —NR c R d or —OR c ; wherein R a , R b , R c and R d , are the same or different, and are each independently hydrogen or a group optionally further substituted, selected from straight or branched C 1 -C 6 alkyl, straight or branched C 2 -C 6 alkenyl, straight or branched C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl or cycloalkyl C 1 -C 6 alkyl, aryl or aryl C 1 -C 6 alkyl, or heterocycle or heterocycle C 1 -C 6 alkyl or, taken together with the nitrogen atom to which they are bonded, R a and R b as well as R C and R d , may form a 1,3-dioxolane, pyran, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazolidine, pyrazoline, piperidine, piperazine, morpholine, tetrahydrofuran, hexamethylenediamine, 1,4-hexahydrodiazepine or azetidine group; R 2 is a group, optionally further substituted, selected from straight or branched C 1 -C 6 alkyl, straight or branched C 2 -C 6 alkenyl, straight or branched C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl or cycloalkyl C 1 -C 6 alkyl, aryl or aryl C 1 -C 6 alkyl, or heterocycle or heterocycle C 1 -C 6 alkyl; or isomers, tautomers, and pharmaceutically acceptable salts thereof.