Patent ID: 8623836

Claim:
A method of reducing the expression of growth hormone receptor in an animal comprising: identifying an animal in need of a reduction in said animal's expression of growth hormone receptor; and systemically administering to said animal in need thereof a modified oligonucleotide 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 nucleobases in length, wherein said modified oligonucleotide is fully complementary over the entirety of said modified oligonucleotide to a human growth hormone receptor RNA, wherein said modified oligonucleotide comprises at least one modified internucleoside linkage, or at least one modified sugar moiety, or at least one modified nucleobase, wherein the expression of growth hormone receptor mRNA in a liver of said animal is reduced, and wherein the modified oligonucleotide comprises SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, 40, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 73, 74, 75, 76, 77, 78, 79, 81, 82, 83, 84, 85, 86, 87, 88, 89, 91, 92, 93 or 94.