Patent ID: 8343968

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof, or an optical isomer thereof, having the formula I wherein R 1 is C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R 2 is —O(CH 2 ) 1-3 OCH 3 or —(CH 2 ) 1-3 OCH 3 ; R 3 is selected from the group consisting of: hydrogen, and —O(CH 2 ) 2 C(CH 3 ) 2 R 5 ; R 4 is selected from the group consisting of: hydrogen, —C(O)OCH 3 , —C(O)NH—C 1 -C 6 alkyl, —COOH, R 5 is selected from the group consisting of —COOH, —COOC 1 -C 6 alkyl; R 6 is selected from the group consisting of: —COOR 9 , —CH 2 COOR 9 , —CON(CH 3 )SO 2 CH 3 , —CONHSO 2 CH 3 , —C(O)NH 2 —CH(CH 2 CH 3 )COOH, —CONHSO 2 CH 3 , —NH 2 , R 7 and R 8 are independently selected from the group consisting of: hydrogen, —C 1-6 alkyl, —OH, —OCH 3 , —COOH, —NH 2 , and or R 7 and R 8 , together with the atom to which they are attached, form a C 3-8 cycloalkyl ring; R 9 is selected from the group consisting of: hydrogen, —C 1 -C 6 alkyl, —(CH 2 ) 2-4 CH(ONO 2 )CH 2 ONO 2 , —CH 2 C(O)N(CH 3 ) 2 , —CH 2 OCOC(CH 3 ) 3 , —CH 2 OCH 2 OCOCH 3 , —CH(CH 3 )OCOCH(CH 3 ) 2 , —CH(CH 3 )COOCH 2 CH 3 , —CH 2 CH 2 N(CH 3 ) 2 , —CH(CH 3 )OCOOCH 2 CH 3 , —CH(CH 3 )OCOOCH(CH 3 ) 2 , R 10 is selected from the group consisting of: hydrogen, —COOCH 3 , —COOCH(CH 3 )OCOCH 3 , W is a phenyl ring or a six-membered, aromatic ring containing one to four nitrogen atoms, wherein said rings are substituted by V in para position; V is a bond; —(CH 2 ) r —; -A-(CH 2 ) s —; —CH 2 -A-(CH 2 ) t —; —(CH 2 ) s -A-; —(CH 2 ) 2 -A-(CH 2 ) u —; -A-(CH 2 ) v —B—; —CH 2 —CH 2 —CH 2 -A-CH 2 —; -A-CH 2 —CH 2 —B—CH 2 —; —CH 2 -A-CH 2 —CH 2 —B—; —CH 2 —CH 2 —CH 2 -A-CH 2 —CH 2 —; —CH 2 —CH 2 —CH 2 —CH 2 -A-CH 2 —; -A-CH 2 —CH 2 —B—CH 2 —CH 2 —; —CH 2 -A-CH 2 —CH 2 —B—CH 2 —; —CH 2 -A-CH 2 —CH 2 —CH 2 —B—; —CH 2 —CH 2 -A-CH 2 —CH 2 —B—; —O—CH 2 —CH(OCH 3 )—CH 2 —O—; —O—CH 2 —CH(CH 3 )—CH 2 —O—; —O—CH 2 —CH(CF 3 )—CH 2 —O—; —O—CH 2 —C(CH 3 ) 2 —CH 2 —O—; —O—CH 2 —C(CH 3 ) 2 —O—; —O—C(CH 3 ) 2 —CH 2 —O—; —O—CH 2 —CH(CH 3 )—O—; —O—CH(CH 3 )—CH 2 —O—; —O—CH 2 —C(CH 2 CH 2 )—O—; or —O—C(CH 2 CH 2 )—CH 2 —O—; A and B are independently selected from the group consisting of —O—, —S—, —S(O)— and —S(O) 2 —; U is unsubstituted aryl; mono-, di-, tri- or tetra-substituted aryl wherein the substituents are independently selected from the group consisting of halogen, alkyl, alkoxy, and —CF 3 ; or mono-, di-, or tri-substituted heteroaryl wherein the substituents are independently selected from the group consisting of halogen, alkyl, alkoxy, and —CF 3 ; Q is methylene or ethylene; n is the integer 0 or 1; r is the integer 3, 4, 5, or 6; s is the integer 2, 3, 4, or 5; t is the integer 1, 2, 3, or 4; u is the integer 1, 2, or 3; and v is the integer 2, 3, or 4.