Patent ID: 8338417

Claim:
A compound of Formula I: in which L is selected from —NHC(O)—, —NHC(O)N— and —C(O)NH—; R 1 , R 2a and R 2b are each independently selected from hydrogen, hydroxy, C 3-8 heterocycloalkyl, C 1-4 -alkyl, C 1-4 -alkoxy, halo-substituted-C 1-4 alkoxy, halo-substituted-C 1-4 alkyl, —NR 10 R 11 , —OX 1 R 8 ; wherein X 1 is selected from a bond and C 1-4 alkylene; R 8 is C 3-12 cycloalkyl; or R 1 and R 2a or R 1 and R 2b together with the carbon atoms to which R 1 and R 2a or R 2b are attached form phenyl; R 10 and R 11 are independently selected from hydrogen, C 1-4 -alkyl, C 1-4 -alkoxy, halo-substituted-C 1-4 alkoxy, halo-substituted-C 1-4 -alkyl, C 3-8 heterocycloalkyl, C 1-10 heteroaryl; or R 10 and R 11 together with the nitrogen to which R 10 and R 11 are both attached form C 3-8 heterocycloalkyl or C 1-10 heteroaryl; R 3 , R 4 , R 5 , R 6 and R 7 are independently selected from hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, C 3-8 heterocycloalkyl, —OX 2 R 9 , —S(O) 0-2 R 9 and —NR 12 R 13 ; wherein X 2 is selected from a bond and C 1-4 alkylene; and each R 9 is independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, C 3-12 cycloalkyl, and C 3-8 heterocycloalkyl; wherein said cycloalkyl or heterocycloalkyl of R 9 is optionally substituted with 1 to 3 radicals independently selected from C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and —NR 12 R 13 ; wherein R 12 and R 13 are independently selected from hydrogen and C 1-6 alkyl; or R 4 and R 5 together with the carbon atoms to which R 4 and R 5 are attached form C 3-8 heteroaryl; with the proviso that at least one of R 3 , R 4 , R 5 , R 6 or R 7 has a sulfur directly linked to the phenyl ring; and the pharmaceutically acceptable salts thereof.