Patent ID: 7381803

Claim:
A humanized antibody comprising a humanized heavy chain and humanized light chain, wherein: (1) the humanized heavy chain variable region comprise three complementarity determining regions (CDRS) from the mouse M291 heavy chain and a framework from a human acceptor antibody heavy chain, optionally having one or more human framework residues that interact with one of the CDRs substituted with mouse framework residues from corresponding positions in the M291 heavy chain variable region framework, and (2) the humanized light chain variable region comprises three complementarity determining regions from the mouse M291 light chain and a framework from a human acceptor antibody light chain optionally having one or more human framework residues that interact with one of the CDRs substituted with mouse framework residues from corresponding positions in the M291 light chain variable region framework; and the humanized antibody specifically binds to a CD3 antigen on the surface of T cells, wherein the mouse M291 antibody has a heavy chain with a variable region of sequence SEQ. ID. No. 11 and a light chain with a variable region of sequence SEQ. ID. No. 9.