Patent ID: 8377654

Claim:
A method for the production of a medicament containing a polypeptide which is in stable form for storage for at least one year, and optionally contains a pharmaceutically acceptable carrier, said polypeptide comprising at least one recombinant carbohydrate-binding polypeptide that is the B-chain of a ribosome-inactivating protein or a functional fragment or derivative of said carbohydrate-binding polypeptide wherein said polypeptide comprises a polypeptide selected from the group consisting of (a) said carbohydrate binding polypeptide or a functional fragment or derivative of said carbohydrate binding polypeptide which is fused to a cytotoxically effective peptide to form a fusion protein; (b) said carbohydrate binding polypeptide or a functional fragment or derivative of said carbohydrate binding polypeptide which is linked to another polypeptide which has an enzymatic rRNA-N-glycosidase activity; (c) said carbohydrate binding polypeptide or a functional fragment or derivative of said carbohydrate binding polypeptide which is linked to another polypeptide in which an enzymatic rRNA-N-glycosidase activity has been replaced by another cytotoxic activity; and (d) said carbohydrate binding polypeptide or a functional fragment or derivative of said carbohydrate binding polypeptide, which is linked to a fusion protein, comprising a polypeptide with an enzymatic rRNA-N-glycosidase activity and/or another cytotoxic activity; comprising the step of cooling, freezing, spray drying or lyophilising while retaining the pharmacological properties of the polypeptide in the solution, wherein said solution has a pH value higher than pH 6.0 and a buffer system which maintains this pH-value, and a lyoprotector in a final concentration of between 4.0 and 10%, wherein said lyoprotector is a dextran.