Patent ID: 7258867

Claim:
An exoprotein inhibitor for inhibiting the production of exoproteins from Gram positive bacteria in and around the vagina comprising a non-absorbent substrate for insertion into a vagina being selected from the group consisting of a non-absorbent incontinence device, a barrier birth control device, a tampon applicator, and a douche, the non-absorbent substrate having deposited thereon an effective amount of a first active ingredient, an effective amount of a second active ingredient, and a pharmaceutically active material selected from the group consisting of antimicrobials, antioxidants, anti-parasitic agents, antipruritics, astringents, local anaesthetics, and anti-inflammatory agents, the first active ingredient having the general formula: wherein R 1 is selected from the group consisting of H, —C(O)NH 2 and salts thereof; R 5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R 6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R 7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R 8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R 2 , R 3 , and R 4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R 9 ; R 9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety, the second active ingredient having the general formula: R 10 —O—R 11 wherein R 10 is a straight or branched alkyl or straight or branched alkenyl having from 8 to about 18 carbon atoms and R 11 is selected from the group consisting of an alcohol, a polyalkoxylated sulfosuccinate salt, and wherein the first active ingredient and the second active ingredient are effective in inhibiting the production of exoprotein from Gram positive bacteria.