Patent ID: 8367110

Claim:
A degradable polymeric drug delivery composition comprising voclosporin blended with a copolymer comprising from 3 mol % to 12 mol % biocompatible tyrosine-derived diphenol compound monomer units with pendant carboxylic acid groups polymerized with from 79 mol % to 91 mol % biocompatible tyrosine-derived diphenol compound monomer units with pendant carboxylic acid ester groups, and from 6 mol % to 18 mol % poly(alkylene oxide) blocks, wherein a molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and polyalkylene oxide blocks relative to a weight percentage of voclosporin in the composition is effective to provide pseudo-zero order release of voclosporin from the composition during a sustained-release phase of drug delivery under physiological conditions, and said voclosporin is present in an amount from about 0.5 wt % to about 80 wt % of the composition.