Patent ID: 7833990

Claim:
A method of activating angiogenesis in a subject in need thereof, comprising administering to said subject a composition comprising a sulfated polysaccharide derivative of a GY 785 polysaccharide produced by the marine bacterium Alteromonas infernus , wherein the sulfated polysaccharide derivative has a molecular weight of less than or equal to 25,000 g/mol, a polydispersity index of less than 2 and a degree of sulfate-group substitution of less than or equal to 45%, and is obtained according to a preparation process comprising at least the following steps: a first step consisting of chemical sulfation, comprising: a) a first substep consisting of dissolution, in an anhydrous solvent, of a lyophilized GY 785 (EPS GY 785) polysaccharide, and b) a second substep consisting of addition, at a temperature of between 45 and 60° C., of at least one chemical sulfation agent in an amount sufficient to produce a sulfated polysaccharide having a degree of sulfate-group substitution of less than or equal to 45% by weight relative to the total weight of the sulfated polysaccharide; a second step consisting of free-radical depolymerisation of the sulfated polysaccharide obtained in the previous step, so as to produce a sulfated polysaccharide derivative having a molecular weight of less than or equal to 25,000 g/mol and a polydispersity index of less than 2, and wherein said composition is administered to said subject in a therapeutically effective amount, thereby activating angiogenesis in the subject.