Patent ID: 8652529

Claim:
An anti-misuse solid oral pharmaceutical formulation, whereby said formulation comprises coated microparticles resistant to crushing for the modified release of at least one active principle (AP) selected from the group consisting of: amphetamines, narcotics, anorexigenics, antidepressants, antiepileptics, antiparkinsonism substances, anxiolytics, barbiturates, benzodiazepines, hypnotics, neuroleptics, opioids, psychostimulants, psychotropic substances and mixtures thereof, wherein said coated microparticles are inert cores covered with at least one layer containing AP and at least one coating layer (Ra), whereby said at least one coating layer (Ra) represents a fraction by weight (Tp) greater than 30%, expressed in % by dry weight, based on the total weight of the coated microparticles, whereby said at least one coating layer (Ra) comprises: at least one film-forming (co)polymer (A1) insoluble in the gastrointestinal juices present in a proportion of 60% to 90% by weight on a dry basis, relative to the total mass of the coating composition; at least one (co)polymer soluble in the gastrointestinal juices (A2) present in a proportion of 5% to 40% by weight on a dry basis, relative to the total mass of the coating composition; at least one plasticizer (A3) present in a proportion of 1% to 30% by weight on a dry basis, relative to the total mass of the coating composition; and wherein said formulation further comprises at least one viscosifier (Vb).