Patent ID: 8921394

Claim:
A compound of structural formula I-1 or I-2: or a pharmaceutically acceptable salt thereof; wherein X is CH or N; each R 1 is independently selected from the group consisting of: (1) —C 1-6 alkyl, (2) —(CH 2 ) m —C(O)-aryl, (3) —(CH 2 ) m —CH(OH)—(CH 2 ) p -aryl, (4) —(CH 2 ) m —SO 2 -aryl, (5) —(CH 2 ) m C 2-6 cycloheteroalkyl, (6) —(CH 2 ) m aryl, and (7) —(CH 2 ) m heteroaryl, wherein each CH 2 , alkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one to three groups independently selected from R a ; each R 2 is selected from the group consisting of: (1) hydrogen, and (2) —(CH 2 ) n aryl, wherein each CH 2 , and aryl is unsubstituted or substituted with one or two substituents selected from R b ; each R 3 is independently selected from the group consisting of: (1) hydrogen, (2) -aryl, and (3) -heteroaryl, wherein each aryl and heteroaryl is unsubstituted or substituted with one to three substituents selected from R c , provided that at least one of R 2 and R 3 is not hydrogen; each R 4 is independently selected from the group consisting of: (1) hydrogen, and (2) —C 1-6 alkyl, wherein alkyl is unsubstituted or substituted with hydroxy or one to three halogens; each R 5 is independently selected from the group consisting of: (1) hydrogen, (2) —C 1-6 alkyl, (3) —C 1-6 alkoxy, (4) —CF 3 , (5) —(CH 2 ) t C 3-7 cycloalkyl, (6) —(CH 2 ) t C 2-6 cycloheteroalkyl, (7) —(CH 2 ) t aryl, and (8) —(CH 2 ) t heteroaryl, wherein each CH 2 , alkyl, alkoxy, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is unsubstituted or substituted with one to three substituents selected from R d ; each R 6 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —CF 3 , and (4) —C 1-6 alkyl, wherein alkyl is unsubstituted or substituted with hydroxy or one to three halogens; each R a is independently selected from the group consisting of: (1) hydrogen, (2) oxo, (3) halogen, (4) —C 1-4 alkyl, (5) —OC 1-4 alkyl, (6) —CF 3 , (7) —OH, (8) —OCF 3 , (9) —CN, and (10) —CO 2 —C 1-6 alkyl; each R b is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —C 1-4 alkyl, (4) —OC 1-4 alkyl, (5) —CF 3 , (6) —OCF 3 , (7) —CN, and (8) —CO 2 —C 1-6 alkyl; R c is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —C 1-4 alkyl, (4) —OC 1-4 alkyl, (5) —CF 3 , (6) —OCF 3 , (7) —CN, and (8) —CO 2 —C 1-6 alkyl; each R d is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —C 1-4 alkyl, (4) —OC 1-4 alkyl, (5) —CF 3 , (6) —OCF 3 , (7) —CN, and (8) —CO 2 —C 1-6 alkyl; m is selected from 0, 1, 2 and 3; n is selected from 0, 1, 2, and 3; p is selected from 0, 1, 2 and 3; r is selected from 0, 1, and 2; s is selected from 1 and 2; and t is selected from 0, 1, 2 and 3.