Patent ID: 7871611

Claim:
An isolated anti-IGF-1R antibody, or an isolated antigen-binding fragment thereof, wherein said antibody or fragment comprises a light chain variable region and a heavy chain variable region, and wherein: a. said light chain variable region comprises the amino acid sequence of SEQ ID NO:32; and said heavy chain variable region comprises the amino acid sequence of SEQ ID NO:136; or b. said light chain variable region comprises: i. the CDR 1 sequence of residues 24 through 39 of SEQ ID NO:32; and ii. the CDR 2 sequence of residues 55 through 61 of SEQ ID NO:32; and iii. the CDR 3 sequence of residues 94 through 102 of SEQ ID NO:32; and said heavy chain variable region comprises: i. the CDR 1 sequence of residues 31 through 36 of SEQ ID NO:136; and ii. the CDR 2 sequence of residues 51 through 66 of SEQ ID NO:136; and iii. the CDR 3 sequence of residues 99 through 108 of SEQ ID NO:136; or c. said light chain variable region is at least 90 percent identical to SEQ ID NO:32 and said heavy chain variable region is at least 90 percent identical to SEQ ID NO:136.