Patent ID: 7439242

Claim:
A compound having the formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar 1 is substituted or unsubstituted isoquinolinyl, pyrazolyl, imidazolyl, or pyridazinyl; X is —S(O) k —, wherein the subscript k is an integer of from 0 to 2; Y is a divalent linkage selected from the group consisting of —N(R 12 )—S(O) m —, —N(R 12 )C(O)— and —S(O) n —, wherein R 12 is selected from the group consisting of hydrogen and alkyl; and the subscripts m and n are independently integers of from 0 to 2; R 1 is selected from the group consisting of hydrogen, alkyl, arylalkyl, —CO 2 R 14 , —C(O)R 14 , —C(O)NR 15 R 16 , wherein R 14 is selected from the group consisting of hydrogen, alkyl, or arylalkyl; and R 15 and R 16 are independently selected from the group consisting of hydrogen and alkyl, or taken together with the nitrogen to which each is attached form a 5- or 6-membered ring; and R 18 is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, unsubstituted aryl, —OR 19 , —SR 19 and —NR 20 R 21 ; and R 19 is H or (C 1 -C 8 )alkyl; and R 20 and R 21 are independently selected from the group consisting of hydrogen and (C 1 -C 8 )alkyl, or taken together with the nitrogen atom to which each is attached, form a 5-, 6- or 7-membered ring; and R 2 is an aryl group.