Patent ID: 7074792

Claim:
A compound of formula I wherein W is N or CR 7 ; X is N or CR 8 ; Y is N or CR 9 ; Z is N or CR 10 with the proviso that two and no more than two of W, X, Y and Z must be N; n is an integer of 2, 3, 4 or 5; R 1 is an optionally substituted C 1 â€“C 6 alkyl, C 3 â€“C 7 cycloalkyl, aryl, or heteroaryl group or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S; R 2 is H, halogen, or a C 1 â€“C 6 alkyl, C 1 â€“C 6 alkoxy, C 3 â€“C 7 cycloalkyl, aryl or heteroaryl group each optionally substituted; R 3 and R 4 are each independently H or an optionally substituted C 1 â€“C 6 alkyl group; R 5 and R 6 are each independently H or a C 1 â€“C 6 alkyl, C 2 â€“C 6 alkenyl, C 2 â€“C 6 alkynyl, C 3 â€“C 7 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted, or R 5 and R 6 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 8-membered ring optionally containing an additional heteroatom selected from O, NR 11 or SO m ; R 7 , R 8 , R 9 and R 10 are independently H, halogen, CN, OCO 2 R 12 , CO 2 R 13 , CONR 14 R 15 , SO p R 16 , NR 17 R 18 , OR 19 , COR 20 , or a C 1 â€“C 6 alkyl, C 2 â€“C 6 alkenyl, C 2 â€“C 6 alkynyl, C 3 â€“C 7 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 11 , R 12 , R 13 , R 16 , R 19 and R 20 are each independently H or a C 1 â€“C 6 alkyl, C 2 â€“C 6 alkenyl, C 2 â€“C 6 alkynyl, C 3 â€“C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 14 and R 15 are each independently H or an optionally substituted C 1 â€“C 6 alkyl group or R 14 and R 15 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, NR 22 or S; R 17 and R 18 are each independently H or an optionally substituted C 1 â€“C 4 alkyl group or R 17 and R 18 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, NR 21 or SO x ; R 21 and R 22 are each independently H or a C 1 â€“C 6 alkyl, C 2 â€“C 6 alkenyl, C 3 â€“C 7 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; and m, p and x are each independently 0 or an integer of 1 or 2; or a pharmaceutically acceptable salt thereof.