Patent ID: 8263762

Claim:
A compound of formula Ia: wherein: R 1 and R 2 independently are selected from: H, C 1-8 alkyl, C 3-8 cycloalkyl, (C 3-8 cycloalkyl)C 1-8 alkyl-, C 4-10 heterocycle, (C 4-10 heterocycle)C 1-8 alkyl-, C 6-10 aryl, (C 6-10 aryl)C 1-8 alkyl-, C 5-10 heteroaryl, and (C 5-10 heteroaryl)C 1-8 alkyl-; R 3 is —C 1-8 alkyl-; R 4 is independently selected from: H, —C 2-6 alkyl-OR a , —C 2-6 alkyl-NR a R b , C 1-10 alkyl, C 3-8 cycloalkyl, (C 3-8 cycloalkyl)C 1-8 alkyl-, C 6-10 aryl, (C 6-10 aryl)C 1-8 alkyl-, C 5-10 heteroaryl, and (C 5-10 heteroaryl)C 1-8 alkyl-; R 5 is selected from: C 1-8 alkyl, —C 2-6 alkyl-NR a R b , C 3-8 cycloalkyl, (C 3-8 cycloalkyl)C 1-8 alkyl-, C 4-10 heterocycle, (C 4-10 heterocycle)C 1-8 alkyl-, C 6-10 aryl, (C 6-10 aryl)C 1-8 alkyl-, C 5-10 heteroaryl, —C 2-6 alkyl-OR a and (C 5-10 heteroaryl)C 1-8 alkyl-; X is selected from: —CH 2 OR c , —OCO 2 R c , —OCH 2 OC(O)R c , —C(O)NR c R d , —CH 2 SR c , —C(S)OR c , —CH 2 OC(S)R c , C(S)NR c R d and —CH 2 NR c R d ; or X is a C 5-6 heteroaryl; R a and R b are each independently selected from H, C 1-8 alkyl, (C 1-8 alkoxy) 1-3 C 1-8 alkyl-, C 3-8 cycloalkyl, (C 3-8 cycloalkyl)C 1-8 alkyl-, C 6-10 aryl, (C 6-10 aryl)C 1-8 alkyl-, C 5-10 heteroaryl, and (C 5-10 heteroaryl)C 1-8 alkyl-; or R a and R b , together with the nitrogen to which they are attached, form a ring selected from pyrrolidino, piperidino, morpholino, and thiomorpholino ring; R c is selected from: H, C 1-8 alkyl, C 3-6 cycloalkyl, and (C 3-6 cycloalkyl)C 1-8 alkyl-; and R d is selected from: H, C 1-8 alkyl, (C 1-8 alkoxy) 1-3 C 1-8 alkyl-, C 3-8 cycloalkyl, C 6-10 aryl, (C 6-10 aryl)C 1-8 alkyl-, C 5-10 heteroaryl, and (C 5-10 heteroaryl)C 1-8 alkyl-; and stereoisomers or pharmaceutically acceptable salts thereof.