Patent ID: 7144859

Claim:
A peptide of the formula (I), X-A 1 -cyclo(D-Cys-A 3 -A 4 -Lys-A 6 -A 7 )-A 8 -Y, (I) or a pharmaceutically acceptable salt thereof, wherein said peptide or salt exhibits somatostatin agonist activity; and wherein A 1 and A 3 are each independently the D- or L-isomer of an amino acid selected from the group consisting of Phe, Tyr, Tyr(I), Trp, 3-Pal, 4-Pal, Cpa and Nal; A 4 is L-Trp, D-Trp, L-β-methyl-Trp or D-β-methyl-Trp; A 6 is —NH—(CHR 1 ) n —CO—, where n is 2, 3, or 4; A 7 is L- or D-Cys; A 8 is the D- or L-isomer of an amino acid selected from the group consisting of Phe, Tyr, Tyr(I), Trp, Nal, Cpa, Val, Leu, Ile, Ser and Thr; Y is NR 2 R 3 where R 2 and R 3 are each independently H or (C 1 –C 5 )alkyl; R 1 is selected from the group consisting H, (C 1 –C 4 )alkyl and —CH 2 -aryl; wherein said aryl is an optionally substituted moiety selected from the group consisting of phenyl, 1-naphthyl, and 2-naphthyl, wherein said optionally substituted moiety is optionally substituted with one or more substituents each independently selected from the group consisting of (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 2-6 )alkynyl, aryl, aryl(C 1-6 )alkyl, (C 1-6 )alkoxy, —N(R 4 R 5 ), —COOH, —CON(R 4 R 5 ), halo, —OH, —CN, and —NO 2 ; R 4 and R 5 each is, independently for each occurrence, H or (C 1-3 )alkyl; where the Cys of A 2 is bonded to the Cys of A 7 by a di-sulfide bond formed from the thiol groups of each Cys.