Patent ID: 7189732

Claim:
The compounds of formula I: wherein: R 1 is selected from the group consisting of: (a) —C(O)—NH-alkyl or —C(O)—N(alkyl) 2 , wherein the alkyl groups of —C(O)—NH-alkyl or —C(O)—N(alkyl) 2 are optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —NH(alkyl), wherein the alkyl group is optionally substituted with —OH; (3) —N(alkyl) 2 , wherein the alkyl groups are optionally substituted with —OH; (4) —NH—C(O)-alkyl, wherein the alkyl group is optionally substituted with —OH; (5) —C(O)—NH-alkyl, wherein the alkyl group is optionally substituted with —OH; (6) —C(O)—N(alkyl) 2 , wherein the alkyl groups are optionally substituted with —OH; (7) —C(O)—NH 2 ; (8) —O-alkyl, wherein the alkyl group is optionally substituted with —OH; (9)-heterocyclyl; (10) —NH-heterocyclyl; (11) —NH—S(O) 2 -alkyl, wherein the alkyl group is optionally substituted with —OH; (12) —S(O) 2 —NH 2 ; and (13) —S(O)-alkyl, wherein the alkyl group is optionally substituted with —OH; (b) —CN; (c) —C(O)—NH 2 ; (d) —C(O)—NH-heterocyclyl; (e) —C(O)—NH—NH—C(O)—NH 2 ; and (f) —C(O)—NH—NH—C(O)-alkyl, wherein the alkyl group is optionally substituted with —NH(alkyl) or —N(alkyl) 2 ; R 2 is selected from the group consisting of: (a) halogen; (b) heterocyclyl; (c) alkyl, wherein the alkyl group is optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; (d) —NH—C(O)-alkyl, wherein the alkyl group is optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; (e) —NH—S(O) 2 -alkyl, wherein the alkyl group is optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; (f) —(CH 2 ) m —S(O) 2 —NH 2 ; (g) —(CH 2 ) m —S(O) 2 —N(alkyl) 2 ; wherein the alkyl groups are optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; (h) —(CH 2 ) m —S(O) 2 —NH-(alkyl), wherein the alkyl group is optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; (i) —O-alkyl, wherein the alkyl group is optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; and (j) —S(O) n -alkyl, wherein the alkyl group is optionally substituted with one or more constituents selected from the group consisting of: (1) —OH; (2) —O-alkyl; (3) —NH-alkyl; and (4) —N(alkyl) 2 ; x is —CH═ or —N═; m is 0, 1, 2, 3, 4, 5 or 6; n is 0, 1 or 2; and pharmaceutically acceptable salts thereof.