Patent ID: 7045532

Claim:
A method of treating an ACE-2 associated state in a subject, comprising administering to a subject in need of decreasing appetite, decreasing body fat, increasing muscle mass, or treating a body weight disorder, an effective amount of an ACE-2 inhibitor, wherein said ACE-2 inhibitor is of the formula (IV): wherein R 6 is hydroxyl or a protecting prodrug moiety; R 7 is a hydrogen atom, carboxylic acid, arylaminocarbonyl, aroyl, aryl, alkylaminocarbonyl, aminocarbonyl, alkenylaminocarboxy, hydroxyl, alkoxy, ether, thiol, amino group heterocycle, or a protecting prodrug moiety; R 8 is hydrogen, or alkyl, and optionally linked to D to form a cyclic structure; R 9 is lower alkyl or hydrogen; Q is a bond, O, S, CR 3 OH, CR 3 SH, CR 3 NR 3a R 3b , NR 3 , (CR 3 R 3a ) n , O(CR 3 R 3b ) n , or (CR 3 R 3a ) n O(CR 3b R 3c ) n , wherein n is 0, 1, 2, or 3 and R 3 , R 3a , R 3b , and R 3c are each independently hydrogen, substituted or unsubstituted, branched, cyclic, or straight chain C 1 –C 6 alkyl, C 2 –C 6 alkenyl, acyl, arylalkyl, aryloxycarbonyl, arylaminocarbonyl, arylalkylsulfonyl, or aryl; G is a linking moiety; M is an anchor moiety; J is a bond, an alkyl, alkenyl, or alkynyl moiety; D is hydrogen, alkoxy, amine, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, optionally linked to G, M or Q to form a ring; t is 0 or 1; p is 0, 1, 2, 3, 4, or 5; q is 0, 1, 2, or 3, or an enantiomer, diastereomer, mixture of enantiomers, mixture of diastereomers or pharmaceutically acceptable salt thereof; and wherein said inhibitor is not a naturally occurring amino acid.