Patent ID: 8394951

Claim:
A compound having the formula (I): wherein R 1 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, —C(O)OR 1a , —S(O)R 1b , and —S(O) 2 R 1c ; wherein each of R 1a , R 1b , and R 1c is independently hydrogen, alkyl or phenyl-alkyl; R a , R b , R c and R d independently are selected from hydrogen and alkyl; m is an integer from one to five; p is an integer from zero to six; R 2 is selected from acyloxy, hydroxy, thiol, acyl, alkyl, alkoxy, substituted alkyl, substituted alkoxy, amino, substituted amino, aminoacyl, acylamino, azido, carboxyl, carboxylalkyl, cyano, halogen, nitro, aminoacyloxy, oxyacylamino, thioalkoxy, substituted thioalkoxy, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO 2 -alkyl, —SO 2 -substituted alkyl, —SO 2 -aryl, —SO 2 -heteroaryl, and trihalomethyl; X 1 , X 2 , and X 3 are CR 5 or one of X 1 , X 2 , and X 3 is N and rest are CR 5 ; R 5 is selected from hydrogen, halogen, alkyl and substituted alkyl; R 3 and R 4 are, for each occurrence, independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxyl, oxo, thioketo, carboxyl, carboxylalkyl, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO 2 -alkyl, —SO 2 -substituted alkyl, —SO 2 -aryl and —SO 2 -heteroaryl; or R 3 and R 4 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic 4 to 8-membered ring; n is an integer from one to three; Z 1 , Z 2 , and Z 3 are selected from CR 6 R 6a , N, O, and S; Z 4 and Z 5 are selected from N, C, and CR 6 ; R 6 is selected from hydrogen, halogen, alkyl and substituted alkyl; R 6a is selected from hydrogen, halogen, alkyl and substituted alkyl or is absent to satisfy valence requirements; and the dashed lines represent a single bond or double bond; or a salt or stereoisomer thereof.