Patent ID: 7767695

Claim:
A method for treating overweight or obesity, comprising: administering to a subject in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein m is 1, R 1 is C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, which may optionally be substituted with one or more substituents selected from halogen, C 1-6 -alkoxy and hydroxy, C 3-8 -cycloalkyl, C 5-8 -cycloalkenyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, di(C 3-8 -cycloalkyl)-C 1-6 -alkyl, C 3-8 -cycloalkyl-C 2-6 -alkenyl, C 3-8 -cycloalkyl-C 2-6 -alkynyl, C 5-8 -cycloalkenyl-C 1-6 -alkyl, C 5-8 -cycloalkenyl-C 2-6 -alkenyl, C 5-8 -cycloalkenyl-C 2-6 -alkynyl, wherein the cyclic moieties may optionally be substituted with one or more substituents selected from C 1-6 -alkyl, halogen, trifluoromethyl and 2,2,2-trifluoroethyl, R 2 is C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl or C 3-8 -cycloalkyl-C 1-6 -alkyl, X is —CH 2 —(CH 2 ) n —, —(CH 2 ) n —CH═CH—(CH 2 ) p —, —CH 2 —(CH 2 ) n —O—(CH 2 ) p —, —CH 2 —(CH 2 ) n —C(═O)—(CH 2 ) p —, —CH 2 —(CH 2 ) n —S—(CH 2 ) p —, —CH 2 —(CH 2 ) n —S(═O)—(CH 2 ) p — or —CH 2 —(CH 2 ) n —S(═O) 2 —(CH 2 ) p —, n and p are independently 0, 1, 2, 3 or 4, R 3 and R 4 are independently hydrogen, methyl or trifluoromethyl, Y is (a) phenyl, naphthyl, pyridyl, benzoxazolyl or benzothiophenyl, which may optionally be substituted with one or more substituents selected from halogen, nitro, cyano, hydroxy, oxo, C 1-7 -alkanoyl, C 1-6 -alkylthio, C 1-6 -alkylsulfonyl, C 1-6 -alkyl, C 1-6 -alkoxy, C 3-8 -cycloalkyl, trifluoromethyl, trifluoromethoxy, —NR 5 R 6 and —O(C═O)NR 5 R 6 , wherein R 5 and R 6 independently are hydrogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, C 1-7 -alkanoyl or aryl, or R 5 and R 6 together with the nitrogen atom to which they are attached form a 4 to 7 membered, saturated or unsaturated ring, or wherein two substituents in adjacent positions form a radical —O—(CH 2 ) 1-3 —O—, phenyl, phenoxy, phenyl-C 1-6 -alkyl and phenyl-C 1-6 -alkoxy, wherein the ring moieties optionally may be substituted with one or more substituents selected from halogen, nitro, cyano, hydroxy, C 1-7 -alkanoyl, C 1-6 -alkylthio, C 1-6 -alkylsulfonyl, C 1-6 -alkyl, C 1-6 -alkoxy, C 3-8 -cycloalkyl, trifluoromethyl, trifluoromethoxy, —NR 7 R 8 and —O(C═O)NR 7 R 8 , wherein R 7 and R 8 independently are hydrogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, C 1-7 -alkanoyl or aryl, or R 7 and R 8 together with the nitrogen atom to which they are attached form a 4 to 7 membered, saturated or unsaturated ring, or wherein two substituents in adjacent positions form a radical —O—(CH 2 ) 1-3 —O— (b) C 3-8 -cycloalkyl, which may optionally be substituted with one or more substituents selected from C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -alkylthio, cyano, trifluoromethyl, trifluoromethoxy and halogen, as well as any diastereomer or enantiomer or tautomeric form thereof, mixtures of these or a pharmaceutically acceptable salt thereof.