Patent ID: 7847075

Claim:
A compound of formula VII wherein A is selected from the group consisting of O, S and N—(C 1 -C 6 )-alkyl, M and M′ are independently selected from the group consisting of oxy, sulfanediyl, —NR 22 , —(C 1 -C 10 )-alkyl, or —O—(C 1 -C 10 )-alkyl-O—, and —S—(C 1 -C 10 )-alkyl-O— and —NR 22 —(C 1 -C 6 )-alkyl-O—, R 22 is selected from the group of —H and —(C 1 -C 10 )-alkyl, R 14 is selected from the group consisting of —H, —OR 31 , —(C 1 -C 10 )-alkoxy, —(C 2 -C 10 )-alkenyloxy, —(C 2 -C 10 )-alkynyloxy, -halogen, -azido NHR 31 , SR 31 and —NH 2 , R 31 is a protecting group or a reporter group, R 32 and R 17 are independently selected from the group consisting of —H, —(C 1 -C 10 )-alkyl, —(C 2 -C 10 )-alkenyl and —(C 6 -C 22 )-aryl, R 18 is selected from the group consisting of substituted or unsubstituted —(C 1 -C 6 )-alkyl, unsubstituted —(C 1 -C 6 )-alkoxy or —(C 1 -C 6 )-alkoxy substituted one or more times by a group selected from the group consisting of -halogen, p-nitroaryloxy and -cyano, and B is a group of formula I wherein W is selected independently from X, Y and Z from the group consisting of N and CR 2 , Z is selected from the group consisting of N and C with the proviso that if Z is N, then X independently from W and Y is selected from the group consisting of N and CR 3 , and Y independently from W and X is selected from the group consisting of N and CR 4 , and the bond between X and Y is a double bond and the bond between Y and Z is a single bond, and if Z is C, then X is NR 33 , and Y is selected from the group consisting of N and CR 4 and the bond between Z and Y is a double bond and the bond between X and Y is a single bond, R 1 is selected from the group consisting of —H, -halogen, —OR 13 , —SR 19 , —(C 1 -C 10 )-alkyl, —(C 2 -C 10 )-alkenyl, —(C 2 -C 10 )-alkynyl, —NO 2 , and —C(═O)R 11 , R 2 , R 3 and R 4 are independently selected from the group consisting of —H, -halogen, —OR 13 , —SR 19 , —(C 1 -C 10 )-alkyl, —(C 2 -C 10 )-alkenyl, —(C 2 -C 10 )-alkynyl, —NO 2 , —NR 5 R 6 , -cyano, and —C(═O)R 11 , wherein R 11 is selected from the group consisting of —OH, —(C 1 -C 6 )-alkoxy, —(C 6 -C 22 )-aryloxy, and NHR 12 , R 5 , R 6 , R 12 , R 13 , R 19 and R 33 are selected independently from the group consisting of —H, —(C 1 -C 10 )-alkyl, —(C 2 -C 10 )-alkenyl, —(C 2 -C 10 )-alkinyl, —(C 6 -C 22 )-aryl, a protecting group and a reporter group, r and s are independently of each other an integer of 1 to 18, D is the position of attachment of the group to the rest of the nucleic acid binding compound, and wherein alkyl, alkenyl and alkynyl are unsubstituted or substituted by one or more moieties selected from the group consisting of -halogen, —S—(C 1 -C 6 )-alkyl, —(C 1 -C 6 )-alkoxy, —NR 5 R 6 , —CO—R 11 , —NH—CO—NR 5 R 6 , —NH—CSNR 5 R 6 and —[O—(CH 2 ) r ] s —NR 5 R 6 , with the proviso that at least one of R 5 and R 6 of —NR 5 R 6 is a protecting group.