Patent ID: 8664230

Claim:
A compound of formula I, Wherein X is O or N or S; Y is CH or N; R 1 is selected from the group consisting of: C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7heterocycloalkyl, substituted C3-C7 heterocycloalkyl, alkylcarboxy, arylamino, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, substituted arylcycloalkyl, heteroarylalkyl, and substituted heteroarylalkyl; R 2 is selected from the group consisting of: hydrogen, halogen, acyl, amino, substituted amino, C1-C6alkyl, substituted C1-C6alkyl, C3-C7cycloalkyl, substituted C3-7Ccycloalkyl, C3-7Cheterocycloalkyl, substituted C3-C7heterocycloalkyl, alkylcarboxy, arylamino, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, arylcycloalkyl, substituted arylcycloalkyl, heteroarylalkyl, substituted heteroarylalkyl, cyano, nitro, alkoxy, C3-C7cycloalkyloxy, substituted C3-C7cycloalkyloxy, C3-C7heterocycloalkyloxy, substituted C3-7Cheterocycloalkyloxy, acyloxy, aryloxy; R 3 =NR 4′ SO 2 R 4 or SO 2 NR 4′ R 4 ; R 4 is selected from the group consisting of: alkyl, substituted alkyl, amino, halo, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7heterocycloalkyl, substituted C3-C7heterocycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; R 4′ is H or C1-C6 alkyl; R 5 is selected from the group consisting of: hydrogen, halogen, C1-C6alkyl; R 6 is selected from the group consisting of: hydrogen, halogen, acyl, alkoxy, amino, substituted amino, arylamino, C1-C6alkyl, substituted C1-C6 alkyl, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7heterocycloalkyl, substituted C3-C7heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; n is 0 or 1; m is 0 or 1; or a pharmaceutically acceptable salt, or tautomer thereof.