Patent ID: 7662369

Claim:
A composition comprising biologically active interferon-β (IFN-β) and highly purified mannitol, wherein said IFN-β has an amino acid sequence selected from the group consisting of: a) the amino acid sequence set forth in SEQ ID NO:1; b) the amino acid sequence set forth in SEQ ID NO:2; and c) an amino acid sequence having at least 90% sequence identity with the amino acid sequence set forth in SEQ ID NO:1 as calculated using version 2.0 of the ALIGN program with a PAM 120 weight residue table, a gap length penalty of 12, and a gap penalty of 4; and having at least about 25% of the biologically activity of IFN-β having the amino acid sequence set forth in SEQ ID NO:1: wherein said highly purified mannitol has a reducing activity of less than 20 parts per million, and wherein said composition has a pH of about 3.0 to about 9.0.