Patent ID: 7993648

Claim:
An immunostimulatory regimen for inducing CD70 expression on dendritic cells in a human subject in need thereof comprising administering type 1 interferon and an immune agonist polypeptide other than said type 1 interferon, and further including the administration of a tumor antigen, wherein said regimen does not include the administration of a TLR agonist and further requires that the only immune agonist polypeptide other than said type 1 interferon administered in said immunostimulatory regimen consists of a CD40 agonistic antibody or a CD40 agonistic antibody fragment polypeptide, and further wherein said CD40 agonistic antibody or CD40 agonistic antibody fragment and said type 1 interferon are administered in amounts that in combination, but not separately, result in the synergistic induction of CD70 expression on dendritic cells and expansion of CD8 + T cells.