Patent ID: 8632797

Claim:
A surgical graft, for use in promoting healing of a diseased or injured tendon, comprising: an acellular, lyophilized, biologically derived matrix comprising a collagen; and at least one therapeutic agent, releasably coupled to the matrix and comprising an expression system, the expression system configured to result in expression of at least one therapeutic protein; wherein the graft is sized and shaped to be placed in a patient's body cavity in proximity to a diseased or injured tendon; wherein, when the graft is placed in the body cavity, the at least one therapeutic agent is released into the tendon; wherein the at least one therapeutic agent is in an amount effective to promote healing of the tendon and to reduce an amount of fibrotic adhesion of the tendon relative to a tendon that has been treated with a graft that does not include the therapeutic agent; and wherein the expression system comprises a recombinant adeno-associated virus carrying a nucleic acid having the sequence of SEQ ID NO: 1.