Patent ID: 7718777

Claim:
A protein comprising an immunoglobulin heavy chain variable (VH) domain and an immunoglobulin light chain variable (VL) domain, wherein the protein binds a complex comprising a major histocompatibility complex (MHC) which comprises HLA-A*0201 and a hTERT-derived peptide T540 (ILAKFLHWL; SEQ ID NO:5), does not substantially bind the MHC in the absence of the bound peptide, and does not substantially bind the peptide in the absence of the MHC, and comprises all the six CDRs of the variable region of the light chain and of the heavy chain, respectively, 4A9 (SEQ ID NOs:84 and 86), or 4G9 (SEQ ID NOs:96 and 98), or 4C2 (SEQ ID NOs:92 and 94), or 4B4 (SEQ ID NOs:88 and 90).