Patent ID: 8211883

Claim:
A pharmaceutical composition for topical administration, comprising a phthalocyanine that has a structure of formula (II) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein M is (G) a Y[(OSi(CH 3 ) 2 (CH 2 ) b N c (R′) d (R″) e ) f X g ] p ; Y is selected from Si, Al, Ga, Ge, or Sn; R′ is selected from H, CH 3 , C 2 H 5 , C 4 H 9 , C 4 H 8 NH, C 4 H 8 N, C 4 H 8 NCH 3 , C 4 H 8 S, C 4 H 8 O, C 4 H 8 Se, OC(O)CH 3 , OC(O), CS, CO, CSe, OH, C 4 H 8 N(CH 2 ) 3 CH 3 , (CH 2 ) 2 N(CH 3 ) 2 , (CH 2 ) n N((CH 2 ) o (CH 3 )) 2 , and an alkyl group having from 1 to 12 carbon atoms; R″ is selected from H, SO 2 CH 3 , (CH 2 ) 2 N(CH 3 ) 2 , (CH 2 ) 11 CH 3 , C(S)NHC 6 H 11 O 5 , (CH 2 ) n N((CH 2 ) o (CH 3 )) 2 , and an alkyl group having from 1 to 12 carbon atoms; G is selected from OH and CH 3 ; X is selected from hydrobromide, hydrochloride, sulfate, bisulfate, phosphate, nitrate, acetate, pyruvate, valerate, oleate, palmitate, stearate, laurate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate, naphthylate, mesylate, glucoheptonate, lactobionate, and laurylsulphonate forming anions; a is 0 or 1; b is an integer from 2 to 12; c is 0 or 1; d is an integer from 0 to 3; e is an integer from 0 to 2; f is 1 or 2; g is 0 or 1; n is an integer from 1 to 12; o is an integer from 1 to 11; p is 1 or 2 R 1 -R 16 are each independently selected from hydrogen, halogen, nitro, cyano, hydroxy, thiol, amino, carboxy, aryl, heteroaryl, carbocyclyl, heterocyclyl, C 1-20 alkyl, C 1-20 alkenyl, C 1-20 alkynyl, C 1-20 alkoxy, C 1-20 acyl, C 1-20 alkylcarbonyloxy, C 1-20 aralkyl, C 1-20 hetaralkyl, C 1-20 carbocyclylalkyl, C 1-20 heterocyclylakl, C 1-20 aminoalkyl, C 1-20 alkylamino, C 1-20 thioalkyl, C 1-20 alicylthio, C 1-20 hydroxyalkyl, C 1-20 alkyloxycarbonyl, C 1-20 alkylaminocarbonyl, C 1-20 alkylcarbonylamino, C 1-20 alkyl-Z—C 1-10 alkyl; R 17 is selected from hydrogen, C 1-20 acyl, C 1-20 alkyl, and C 1-20 aralkyl; and Z is selected from S, NR 17 , and O.