Patent ID: 7838554

Claim:
A method for treating dyslipidemia in a patient comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of the formula I: or a pharmaceutically acceptable salt, hydrate, solvate, or a mixture thereof, wherein (a) each occurrence of Z is independently CH 2 , CH═CH, or phenyl, where each occurrence of m is independently an integer ranging from 1 to 9, but when Z is phenyl then m is 1; (b) G is (CH 2 ) x , where x is 1-7, CH 2 CH═CHCH 2 , CH═CH, CH 2 -phenyl-CH 2 , or phenyl; (c) W 1 and W 2 are independently L, V, C(R 1 )(R 2 )—(CH 2 ) c —C(R 3 )(R 4 )—(CH 2 ) n —Y, or C(R 1 )(R 2 )—(CH 2 ) c V where c is 1 or 2 and n is an integer ranging from 0 to 7; (d) each occurrence of R 1 or R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl or when one or both of W 1 and W 2 is C(R 1 )(R 2 )—(CH 2 ) c —C(R 3 )(R 4 )—(CH 2 ) n —Y, then R 1 and R 2 can both be H to form a methylene group; or R 1 and R 2 and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloakyl group; (e) R 3 is H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, phenyl, benzyl, Cl, Br, CN, NO 2 , or CF 3 ; (f) R 4 is OH, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, phenyl, benzyl, Cl, Br, CN, NO 2 , or CF 3 ; (g) L is C(R 1 )(R 2 )—(CH 2 ) n —Y, wherein n is an integer from 0 to 5; (h) V is: (i) each occurrence of Y is independently (C 1 -C 6 )alkyl, OH, COOH, COOR 5 , SO 3 H, wherein: (i) R 5 is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 6 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, (C 1 -C 6 ) alkoxy, or phenyl groups; (iii) each occurrence of R 7 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; and (j) X is (CH 2 ) z or Ph, wherein z is an integer from 0 to 4.