Patent ID: 7112580

Claim:
A compound of the formula and pharmaceutically acceptable salts, solvates, and stereoisomers thereof, in isolation or in mixture, where independently at each occurrence: R 1 and R 2 are selected from hydrogen, oxygen so as to form nitro or oxime, amino, sulfur so as to form —SO 3 —R or —SO 2 —R wherein R is selected from H and organic groups having 1–30 carbons optionally containing 1–6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon and sulfur, and organic groups having 1–30 carbons optionally containing 1–6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon, and sulfur; R 3 and R 4 are selected from direct bonds to the carbon at numeral 6 and the carbon at numeral 7 respectively so as to form carbonyl groups, hydrogen, or a protecting group such that R 3 and/or R 4 is part of hydroxyl or carbonyl protecting group; numerals 1 through 17 each represent a carbon; the carbons at numerals 1, 2, 4, 11, 12, 15, and 16 are each independently substituted with (a) one of: ═O, ═C(R 5 )(R 5 ), ═C═C(R 5 )(R 5 ), —C(R 5 )(R 5 )(C(R 5 )(R 5 )) n — and —(O(C(R 5 )(R 5 )) n O)— wherein n ranges from 1 to about 6; or (b) two of the following, which are independently selected: —X, —N(R 1 )(R 2 ), —R 5 and —OR 6 ; the carbons at numerals 5, 8, 9, 10, 13 and 14 are each independently substituted with one of —X, —R 5 , —N(R 1 )(R 2 ) or —OR 6 ; the carbon at numeral 17 is substituted with —C(R 5 )(R 5 )(C(R 5 )(R 5 )) n — or —(O(C(R 5 )(R 5 )) n O)— wherein n ranges from 1 to about 6; in addition to the —OR 3 and —OR 4 groups as shown, each of the carbons at numerals 6 and 7 are independently substituted with one of —X, —N(R 1 )(R 2 ), —R 5 or —OR 6 ; each of rings A, B, C and D is independently fully saturated, partially saturated or fully unsaturated; R 5 at each occurrence is independently selected from H, X, and C 1-30 organic moiety optionally containing at least one heteroatom selected from the group consisting of boron, halogen, nitrogen, oxygen, silicon and sulfur; where two geminal R 5 groups may together form a ring with the carbon atom to which they are both bonded; R 6 is H or a protecting group such that —OR 6 is a protected hydroxyl group, where vicinal —OR 6 groups may together form a cyclic structure that protects vicinal hydroxyl groups, and where geminal —OR 6 groups may together form a cyclic structure that protects a carbonyl group; and X represents fluoride, chloride, bromide and iodide.