Patent ID: 8633206

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof; wherein the A ring is heterocyclyl; wherein the A ring is optionally substituted with one or more substituents selected from the group consisting of halo, carboxy, cyano, oxo, aryl, heterocyclyl, (C 1 -C 8 )alkyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)OR 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —N(R 18 )S(O) 2 R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of halo, cyano, aryl, heterocyclyl, —OR 23 , —OC(O)R 24 , —NR 25 R 26 , —C(O)NR 27 R 28 , —SR 29 , —SO 2 R 30 , —SO 2 NR 31 R 32 , —N(R 33 )C(O)R 34 , and —N(R 35 )S(O) 2 R 36 ; R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy; n is one or two; R 11 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, heterocyclylcarbonyl(C 1 -C 6 )alkyl, and aminocarbonyl(C 1 -C 6 )alkyl; R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 21 , R 22 , R 24 , R 25 , R 26 , R 27 , R 28 , R 31 , R 32 , R 33 , R 34 , R 35 and R 36 are independently selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl; R 19 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkoxy; R 20 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, aryl(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl; R 23 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, heterocyclyl(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl; R 29 is selected from the group consisting of hydrogen and heterocyclyl; and R 30 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl; wherein aryl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, cyano, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy; wherein heterocyclyl, wherever it occurs, is optionally and independently substituted with one or more substituents selected from the group consisting of oxo, cyano, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkylaminocarbonyl, and (C 1 -C 6 )alkylsulfonyl(C 1 -C 6 )alkyl.