Patent ID: 7618989

Claim:
A compound of the structure: wherein: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently H, C 1 to C 10 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) p —O—(CH 2 ) n -aryl, —(CH 2 ) n C(H) 3-p (R 7 ) p , —(CH 2 ) n COOR 8 , or —(CH 2 ) p —O—R 9 ; or R 1 , R 2 or R 3 , R 4 or R 5 , R 6 are taken together to form a 3 to 6 membered cycloalkyl ring; or when m is 0, R 1 or R 2 form a 5 to 7 membered cycloakyl ring with R 5 or R 6 ; or when m is 0, R 1 or R 2 form a 6-membered aryl ring with R 5 or R 6 ; R 7 is halogen; R 8 is C 1 to C 6 alkyl; R 9 is H, C 1 to C 6 alkyl, or C 1 to C 3 perfluoroalkyl; W is O, NR 10 , or CR 11 R 12 ; R 10 is H, C 1 to C 6 alkyl, or (CH 2 ) n -aryl; R 11 and R 12 are, independently, H, C 1 to C 6 alkyl, or —(CH 2 ) n -aryl; or R 11 or R 12 form a double bond with either R 5 or R 6 ; V is O, S, or NR 13 ; R 13 is H, C 1 to C 6 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) n —CN, —CO—(C 1 to C 6 alkyl), —CO—(CH 2 ) n -aryl, —SO 2 —(C 1 to C 6 alkyl), or —SO 2 —(CH 2 ) n -aryl; X is N or CR 14 ; R 14 is C 1 to C 6 alkyl, —(CH 2 ) n -aryl, —(CH 2 ) n —O—(CH 2 ) n -alkyl, —(CH 2 ) n —O—(CH 2 ) n -aryl, halogen, hydroxy, C 1 to C 3 perfluoroalkyl, C 1 to C 3 perfluoroalkoxy or (CH 2 ) n —CN; Y is O or S; R 16 forms a two carbon saturated or unsaturated bond with Q to give a tricyclic ring system; Q is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; m is 0 or 1; n is 0 to 3; p is 1 to 3; or a pharmaceutically acceptable salt thereof.