Patent ID: 7666840

Claim:
An isolated α-conotoxin polypeptide comprising the amino acid sequence of: Asp-Xaa1-Cys-Cys-Ser-Asn-Xaa5-Ala-Cys-Arg-Val-Asn-Asn-Xaa5-His-Val-Cys-Arg-Arg-Arg (SEQ ID NO:178); wherein Xaa1 is Glu or γ-carboxy-Glu; wherein Xaa5 is Pro or hydroxy-Pro; wherein the C-terminus contains a hydroxyl group or an amide group; wherein the His residue may be substituted with a halo-His residue; wherein an Arg residue may be substituted with homoarginine; and wherein the Cys residues may be in the D or L configuration or substituted with homocysteine in the D or L configuration.