Patent ID: 8865430

Claim:
A dimer formed from two fusion polypeptides of the form (A)-M-(A′), wherein: component A comprises an antibody fragment specific to a target receptor, component A′ comprises either i) an antibody fragment specific to the target receptor; or ii) a ligand or ligand fragment specific to the target receptor, and component M is a multimerizing component comprising an Fc domain of IgG, the dimer being characterized in that, when contacted with a system comprising the target receptor, it binds to and clusters four or more molecules of the target receptor, wherein the target receptor is selected from the group consisting of an EGF receptor, Eph receptor, EPO receptor, FGF receptor, G-CSF receptor, GM-CSF receptor, a VEGF receptor, a PDGF receptor, TGFβ receptor, a Tie receptor and a Trk receptor.