Patent ID: 8920782

Claim:
A bioadhesive pre-formulation not containing any active pharmaceutical ingredient, comprising a low viscosity mixture having a viscosity of 0.1 to 1000 m Pas at 20° C., said low viscosity mixture comprising: a) 30% to 90% by weight of at least one neutral diacyl lipid consisting essentially of diacyl glycerols and containing at least 50% of a glycerol dioleate; b) 10% to 60% by weight of at least one phospholipid having polar head groups consisting of at least 50% phosphatidylcholine; c) 2-30% by weight of at least one biocompatible organic solvent comprising ethanol; wherein the pre-formulation forms at least one liquid crystalline phase structure upon contact with an aqueous fluid and/or body surface; wherein the weight ratios of components a :b are from 85:15 to 30:70.