Patent ID: 7470795

Claim:
A process for preparing a compound of formula I: wherein R 1 is selected from bromo, trifluoromethoxy, cyano and pyrimidin-5-yl optionally mono- or di-subsituted by NH 2 ; and R 2 and R 3 are each independently selected from the group consisting of (A) hydrogen; and (B) a C 1-4 straight or branched alkyl group, optionally mono- or disubstituted with moieties independently selected from oxo, —OH, NH 2 and —C(O)NR 4 R 5 , where R 4 and R 5 are independently selected from: (1) hydrogen, and (2) a C 1-4 straight or branched alkyl group which alkyl group is mono- or disubstituted with moieties independently selected from CONH 2 and OH; or R 2 and R 3 , combined with the nitrogen they are bonded to, form: (1) a pyrrolidine or piperidine ring, each optionally substituted with the group —C(O)NR 6 R 7 , where R 6 and R 7 are independently selected from (A) hydrogen; and (B) a C 1-4 straight or branched alkyl group, optionally mono- or disubstituted with moieties independently selected from oxo, —OH and NH 2 ; (2) a morpholine ring; or (3) a piperazine ring; or a pharmaceutically acceptable salt thereof; said process comprising the step of reacting a compound of formula XXII with a compound of formula R d MgY, where R d is C 1-6 alkyl or C 3-6 cycloalkyl and Y is halogen, sulfur dioxide and N-chlorosuccinimide, followed by a base and a compound of the formula XXIII in an aprotic organic solvent to form a compound of the formula I, without isolation of intermediates formed during this step: