Patent ID: 7041695

Claim:
A compound of formula I wherein X is CR 7 , SO m , or O; Y is CR 9 , SO m , or O; Z is CR 10 , SO m , or O with the proviso that two of X, Y and Z must be CR 7 , CR 9 or CR 10 ; R 1 and R 2 are each independently H, OH or an optionally substituted C 1 –C 6 alkyl group; R 3 and R 4 are each independently H or a C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, or aryl group each optionally substituted; R 5 is H, halogen, or a C 1 –C 6 alkyl, C 2 –C 6 alkoxy, C 3 –C 7 cycloalkyl, or aryl group each optionally substituted; R 6 is an optionally substituted C 1 –C 6 alkyl, C 3 –C 7 cycloalkyl, or aryl group; n is an integer of 2, 3, 4 or 5; R 7 , R 9 and R 10 are each independently H, halogen, CN, OCO 2 R 12 , CO 2 R 13 , CONR 14 R 15 , SO p R 16 , NR 17 R 18 , OR 19 , COR 20 , or a C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, or aryl group each optionally substituted; R 8 , R 11 , R 12 , R 13 , R 16 , R 19 , and R 20 are each independently H or a C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 6 cycloalkyl, or aryl group each optionally substituted; R 14 and R 15 are each independently H or an optionally substituted C 1 –C 6 alkyl group; R 17 and R 18 are each independently H or an optionally substituted C 1 –C 4 alkyl group; R 21 and R 22 are each independently H or a C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 7 cycloalkyl, or aryl group each optionally substituted; and m, p, q and x are each independently 0 or an integer of 1 or 2; and represents a single bond or a double bond; or a stereoisomer thereof or a pharmaceutically acceptable salt thereof.