Patent ID: 6855708

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof wherein: Ring A is cycloalkyl or heterocyclyl, wherein ring A is optionally substituted with one to four substituents independently selected from R c ; X and Y are independently selected from 1) halogen, 2) C 1-3 alkyl, 3) C 1-3 alkoxy; Z is 1) N, 2) N + —O—; R 1 is 1) hydrogen, 2) C 1-10 alkyl, 3) aryl-C 1-10 alkyl; R 2 is 1) hydrogen or 2) C 1-10 alkyl; R 3 and R4 are independently selected from 1) hydrogen, 2) C 1-10 alkyl, 3) —OR d , 4) —CO 2 R d , 5) —C(O)NR d R e , 6) —NR d R e , 7) —NR d S(O) m R e , 8) —NR d C(O)R e , 9) —NR d C(O)OR e , 10) —NR d C(O)NR d R e , wherein alkyl is optionally substituted with one to four substituents independently selected from R a ; R 5 is 1) hydrogen, 2) OH, 3) OCH 3 ; or 4) NH 2 ; R a is 1) —OR d , 2) —NR d S(O) m R e , 3) —NO 2 , 4) halogen 5) —S(O)pRd, 6) —SR d , 7) —S(O) 2 OR d , 8) —S(O) m NR d R e , 9) —NR d R e , 10) —O(CR f R g ) n NR d R e , 11) —C(O)R d , 12) —CO 2 R d , 13) —CO 2 (CR f R g ) n CONR d R e , 14) —OC(O)R d , 15) —CN, 16) —C(O)NR d R e , 17) —NR d C(O)R e , 18) —OC(O)NR d R e , 19) —NR d C(O)OR e , 20) —NR d C(O)NR d R e , 21) —CR d (N—OR e ), 22) CF 3 , 23) —OCF 3 , 24) C 3-8 cycloalkyl, or 25) heterocyclyl; wherein cycloalkyl and heterocyclyl are optionally substituted with one to four groups independently selected from R c ; R c is 1) halogen, 2) amino, 3) carboxy, 4) C 1-4 alkyl, 5) C 1-4 alkoxy, 6) aryl, 7) aryl C 1-4 alkyl, 8) hydroxy, 9) CF 3 , 10) OC(O)C 1-4 alkyl, 11) OC(O)NR f Rg, or 12) aryloxy; R d and R e are independently selected from hydrogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, Cy and Cy C 1-10 alkyl, wherein alkyl, alkenyl, alkynyl and Cy are optionally substituted with one to four substituents independently selected from R c ; or R d and R e together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N—R h ; R f and R g are independently selected from hydrogen, C 1-10 alkyl, Cy and Cy—C 1-10 alkyl; or R f and R g together with the carbon to which they are attached form a ring of 5 to 7 members containing 0-2 heteroatoms independently selected from oxygen, sulfur and nitrogen; R h is selected from R f and —C(O)R f ; Cy is selected from cycloalkyl, heterocyclyl, aryl, and heteroaryl; Ar 1 is selected from phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl each optionally substituted with one or two groups independently selected from R c ; Ar 2 is 1,4-phenylene or 2,5-pyridylene; p is 1 or 2; m is 0, 1 or 2; n is 0, 1 or 2.