Patent ID: 8716265

Claim:
A compound of formula A or a stereoisomer or pharmaceutically acceptable salt thereof: wherein: A is selected from (CH 2 ) n CONHA′ and (CH 2 ) n CONHOH; n is selected from 0, 1, 2, 3, and 4; A′ is selected from H and CR′R″Z; R at each occurrence is independently selected from H and C 1-4 alkyl; R′ is selected from H, C 1-4 alkyl, C 3-6 -cycloalkyl, C 1-4 hydroxyalkyl, phenyl, benzyl, —C 0-4 alkyl-CO 2 R, —C 0-4 alkyl-CONHR a , —C 0-4 alkyl-CONHOH, and —C 0-4 alkyl-C(NH)NH 2 ; R a is selected from H and —C 1-4 alkyl-CONHR b ; R b is selected from C 1-4 alkyl, C 1-4 hydroxyalkyl, C 3-4 alkenyl, C 3-4 alkynyl, phenyl, phenyl-C 1-6 alkyl-, and —C 1-4 alkyl-CONH 2 ; R″ is selected from H and C 1-4 alkyl; alternatively, R′ and R″ together form a C 3-6 cycloalkyl group; X is selected from H, halo, —CN, O—C 1-4 alkyl, C 2-4 alkenyl, CF 3 , and phenyl; X′ is selected from H, halo, —CN, O—C 1-4 alkyl, C 2-4 alkenyl, and CF 3 ; Y is selected from H, halo, —CN, O—C 1-4 alkyl, C 2-4 alkenyl, and CF 3 ; Z is selected from H, C 1-4 alkyl, C 1-4 hydroxyalkyl, C 2-4 alkenyl, C 2-4 alkynyl, phenyl, phenyl-C 1-6 alkyl-, —C 0-4 alkyl-CO 2 R, —C 0-4 alkyl-CONHR c , —C 0-4 alkyl-CONHOH, —C 0-4 alkyl-C(NH)NH 2 , CHOHCH 2 CO 2 R, CHOHCH 2 CONHR c , CHOHCH 2 C(NH)NH 2 , CH 2 CHOHCO 2 R, CH 2 CHOHCONHR c , CH 2 CHOHC(NH)NH 2 , CH═CHCO 2 R, CH═CHCONHQ, CH═CHC(NH)NH 2 , —C 1-4 alkyl-SO 3 R, and —C 1-4 alkyl-SO 2 NHR c ; R c is selected from H, —C 1-4 alkyl-CONHR d , CHOHCH 2 CONHR d , CH 2 CHOHCONHR d , and —C 1-4 alkyl-SO 2 NHR d ; R d is selected from C 1-4 alkyl, C 1-4 hydroxyalkyl, C 3-4 alkenyl, C 3-4 alkynyl, phenyl, phenyl-C 1-6 alkyl-, and —C 1-4 alkyl-CONH 2 ; and, each phenyl or benzyl group is independently optionally substituted with 1-2 groups selected from CF 3 , halogen, C 1-4 alkyl, —CN, CONR 2 , NO 2 , NR 2 , OR, NHSO 2 CH 3 , and SONHR; provided that when A=H, then one of R′ and Z is other than H, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 -cycloalkyl, C 1-4 hydroxyalkyl, phenyl, and phenyl-C 1-6 alkyl-.