Patent ID: 8859021

Claim:
A method of ameliorating or reducing the manifestation or the appearance or depth of lines, wrinkles or creases around the mouth and eyes, between the eyes and on the forehead resulting from chronological aging, hormonal aging, photo-aging and/or actinic aging wherein the method comprises effecting at least a 2 fold up regulation in the expression of one or more genes associated with improving or maintaining the health and integrity of the dermal-epidermal junction (DEJ), at least a 2 fold down regulation in the expression of one or more genes associated with the degradation of the DEJ, or both by administering orally to an individual or topically or intradermally to the aforementioned areas of the skin of an individual manifesting lines, wrinkles or creases a gene manipulatingly effective amount of a composition having a pH of 3.5 to 7 and comprising from 0.5 to 10 wt. percent of a meroterpene and a dermatologically or pharmaceutically acceptable carrier on at least a daily basis until the aforementioned amelioration or reduction is visually noted to the satisfaction of the user, wherein said meroterpene is of the formula wherein R 1 , R 2 , and R 3 are each independently selected from the group consisting of H, OH, OR 6 or CH 2 R 6 where R 6 is a linear or branched C 1 to C 8 alkyl; and R 4 and R 8 are each independently a linear or branched, C 1 to C 20 alkyl or alkenyl group, said meroterpene having a purity of at least 60%.