Patent ID: 7226920

Claim:
A compound having the formula II: or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen or C 1-6 alkyl; R 2 is Ar 1 or Cy 1 , wherein Ar 1 is an aryl group selected from phenyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, or thiadiazolyl and Cy 1 is selected from pyrrolidinyl, pyrazolinyl, thiazolidinyl, or imidazolidinyl; wherein each of Ar 1 and Cy 1 is optionally substituted with 0–5 independent occurrences of Q-R X ; wherein each independent occurrence of Q is a bond or is a C 1-6 alkylidene chain wherein up to two non-adjacent methylene units of Q are optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each independent occurrence of R X is independently selected from R′, halogen, NO 2 , CN, OR′, SR′, N(R′) 2 , NR′C(O)R′, NR′C(O)N(R′) 2 , NR′CO 2 R′, C(O)R′, CO 2 R′, OC(O)R′, C(O)N(R′) 2 , OC(O)N(R′) 2 , SOR′, SO 2 R′, SO 2 N(R′) 2 , NR′SO 2 R′, NR′SO 2 N(R′) 2 , C(O)C(O)R′, or C(O)CH 2 C(O)R′; R 3 is Ar 2 or Cy 2 , wherein Ar 2 is an unsubstituted aryl group selected from phenyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, or thiadiazolyl and Cy 2 is a group selected from pyrrolidinyl, pyrazolinyl, thiazolidinyl, or imidazolidinyl, optionally substituted with up to five substituents selected from Z-R Y ; wherein Z is a bond or is a C 1-6 alkylidene chain wherein up to two non-adjacent methylene units of Z are optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each occurrence of R Y is independently selected from R′, halogen, NO 2 , CN, OR′, SR′, N(R′) 2 , NR′C(O)R′, NR′C(O)N(R′) 2 , NR′CO 2 R′, C(O)R′, CO 2 R′, OC(O)R′, C(O)N(R′) 2 , OC(O)N(R′) 2 , SOR′, SO 2 R′, SO 2 N(R′) 2 , NR′SO 2 R′, NR′SO 2 N(R′) 2 , C(O)C(O)R′, or C(O)CH 2 C(O)R′; and each occurrence of R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group; and each occurrence of R′ is independently selected from hydrogen or an optionally substituted group selected from C 1-8 aliphatic, C 1-10 aryl, a heteroaxyl ring having 5–10 ring atoms, or a heterocyclyl ring having 3–10 ring atoms, or wherein R and R′ taken together, or two occurrences of R′ taken together, form a 5–8 membered cycloalkyl, heterocyclyl, aryl, or heteroaryl ring having 0–3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; provided that when R 3 is unsubstituted phenyl and R 1 is hydrogen, then R 2 is not unsubstituted phenyl.