Patent ID: 8614218

Claim:
A method for the treatment or amelioration of a cancer selected from breast, ovarian, lung, and colon cancers comprising administering to a subject in need thereof an effective amount of a compound of formula (I) wherein ring B and the pyrimidine to which it is fused form a ring system selected from the group consisting of wherein R1 is hydrogen, 1-4C-alkyl, halogen, amino, 1-4C-alkoxy, cyano, 3-7C-cycloalkyl, 2-4C-alkenyl, 2-4C-alkynyl, 3-7C-cycloalkoxy, mono- or di-1-4C-alkylamino, mono- or di-1-4C-alkylaminocarbonyl, —C(O)NH2, —C(O)OR2 or trifluoromethyl, R2 is hydrogen or 1-4C-alkyl, R3 is hydrogen, 1-4C-alkyl or halogen, R4 is phenyl or thienyl, R5 is hydrogen, 1-4C-alkoxy, amino, mono- or di-1-4C-alkylamino, 1-4C-alkyl or 3-7C-cycloalkyl, R6 is hydrogen or 1-4C-alkyl, R7 is —W—Y, W is a monocyclic 5-membered heteroarylene comprising 1 nitrogen atom and optionally 1 or 2 further heteroatoms independently selected from consisting of oxygen, nitrogen and sulphur, and wherein the heteroarylene is optionally substituted by R8, R8 is 1-4C-alkyl or 3-7C-cycloalkyl, Y is phenyl or a monocyclic 5 or 6 membered heteroaryl comprising 1 nitrogen, oxygen or sulfur atom and optionally 1 or 2 further heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulphur, and wherein the heteroaryl is optionally substituted by R9, R9 is 1-4C-alkyl, 1-4C-alkoxy or halogen, or a salt, a tautomer, or a stereoisomer thereof, or a salt of said tautomer or said stereoisomer.