Patent ID: 8450380

Claim:
A method for manufacturing a formulation comprising a pharmaceutical active ingredient, comprising: a) mixing a Hydrophobically Alkali Swellable Emulsion (HASE), a pharmaceutical active ingredient, and water to produce a mixture, said mixture having a pH greater than 5, b) optionally precipitating from said mixture, by adjusting the pH to a value less than 3, a dispersion of solid particles in water, c) optionally purifying the solid particles, wherein the HASE comprises at least one copolymer of (meth)acrylic acid, a non-hydrosoluble monomer and a monomer comprising at least one hydrophobic group of the formula: where: m, n, p and q are integers and m, n, p are less than 150, R has a polymerizable vinylic function, R 1 and R 2 are identical or different, and represent hydrogen atoms or alkyl groups, and R′ is a hydrophobic group comprising at least 6 carbon atoms.