Patent ID: 8246976

Claim:
A method of manipulating the drug delivery rate and profile of a drug from a transdermal drug delivery system, comprising: (A) providing a pressure-sensitive adhesive composition which includes a blend of: (a) one or more polymers selected from the group consisting of a rubber based polymer, an acrylic based polymer and a polysiloxane; and (b) a pharmacologically effective amount of at least one drug for transdermal drug delivery, wherein said at least one drug is selected from the group consisting of frovatriptan and clonidine and is (i) incorporated in said pressure sensitive adhesive in crystal form having a small crystal size; (ii) incorporated in said pressure sensitive adhesive in crystal form having a larger crystal size, and (iii) optionally, solublized in said pressure sensitive adhesive; (B) selectively tailoring the pressure-sensitive adhesive composition and the amount of drug having a small crystal size and the amount of drug having a larger crystal size, and optionally, the amount solubilized drug, to control the drug delivery rate and profile of the drug from the transdermal drug delivery system.