Patent ID: 7402703

Claim:
A process for a Zr-mediated hydroboration of alkynes comprising: reacting a substituted terminal alkyne of formula (I) with a compound of formula II: Without a solvent or in an inert solvent in the presence of bis(cyclopentadienyl)zirconium chloride hydride and an amine at temperatures of about 20-150° C., to obtain a compound of formula (III): wherein: X is a divalent group comprising an alkyl, an aryl or a heteroaryl; R 1 is an alkyl, wherein two R 1 groups can optionally form a 5-12 membered mono-cyclic or bicyclic ring; Y is a H, an alkyl, an alkenyl, an aryl or heteroaryl, halogen, CN, NH 2 , CO 2 H, N 3 , CHO, CF 3 , OCF 3 , OR 2 , OSi(R 2 ) 3 , S(O) m R 2 , OS(O) m R 2 , Q, OR 3 Q, NR 2 S(O) m R 2 , OR 3 OR 2 , wherein R 3 and R 2 together may optionally form a heterocyclic ring, OR 2 Q, N(R 2 )R 3 OR 2 , N(R 2 )R 3 Q, NR 2 C(O)R 2 , C(O)R 2 , C(O)OR 2 , C(O)Q, OC(O)R 2 , OC(O)Q, NR 2 C(O)R 2 , NR 2 C(O)OR 2 , NR 2 C(O)Q; m=0-2; R 2 is a H, an alkyl, an alkenyl, or an aryl optionally substituted by an alkyl; R 3 is a divalent alkyl, or an alkenyl; Q is NZZ′ or N(O)ZZ′; Z and Z′ may be the same or different group comprising, a H, an alkyl, an alkenyl, an aryl or heteroaryl, wherein Z and Z′ taken together with the nitrogen to which they are attached may form a heterocyclic ring.