Patent ID: 8524275

Claim:
An oral dosage form comprising: a therapeutically effective amount of an opioid analgesic, an opioid antagonist, one or more pharmaceutically acceptable excipients, and particles of a gelling agent in a substantially non-releasable form, the particles consisting of the gelling agent formulated with effective amounts of (i) one or more pharmaceutically acceptable hydrophobic material(s) selected from the group consisting of cellulose polymers, acrylic polymers, polylactic acid, polyglycolic acid and a co-polymer of the polylactic acid and polyglycolic acid, and (ii) one or more additional pharmaceutically acceptable excipient(s) to sequester the gelling agent such that the gelling agent is not substantially released from the dosage form which is administered intact, but is released from the dosage form which is crushed in an effective amount to hinder, deter or prevent the administration of the crushed dosage form and form a viscous gel with a viscosity of at least about 10 cP when the crushed dosage form is mixed with from about 0.5 to about 10 ml of an aqueous liquid, wherein the opioid antagonist is in an effective amount to attenuate a side effect of the opioid analgesic, the gelling agent is selected from the group consisting of polyethylene oxides, surfactants, emulsifiers and mixtures thereof, and a weight ratio of the gelling agent to the opioid analgesic is from about 1:40 to about 40:1.