Patent ID: 7288564

Claim:
A compounds of formula (I): or salts or solvates thereof or physiologically functional derivatives thereof wherein: a=0, 1 or 2; b=0 or 1; X is selected from the group consisting of C(O)NR; R is selected from the group consisting of H and C 1-4 alkyl; R 0 , R 1 , R 2 and R 3 each independently are selected from the group consisting of H, halogen, C 1-6 alkyl, S—C 1-6 alkyl, C 1-6 alkoxy, OCF 3 , OCH 2 CF 3 , O-cyclopropyl, OCH 2 -cyclopropyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , NO 2 , OH, CH 2 OC 1-6 alkyl, CH 2 OH, arylC 1-6 alkylenoxy, C 1-6 alkyl-SO 2 NH—C 1-4 alkylene, aryl and heteroaryl; R 4 is selected from the group consisting of H, C 1-6 alkyl, aryl and heteroaryl; R 5 each is independently selected from the group consisting of H, CH 3 and F; R 6 is selected from the group consisting of SO 3 H, SO 2 NH 2 , CH 2 CO 2 H, SO 2 NHCOR, CONHSO 2 R, P(O)(OH) 2 , heteroaryl and C(O)Z where Z is OH or NR 9 2 wherein each R 9 independently is selected from the group consisting of H, C 1-6 alkyl and SO 2 (CH 2 ) c aryl, wherein c=0 or 1; R 7 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkoxy, halogen, NO 2 , CH═CHCO 2 C 1-6 alkyl, NHCOC 1-6 alkyl, C 1-2 perfluoroalkyl, OH and CO 2 R 10 wherein R 10 is selected from the group consisting of H and C 1-6 alkyl; and R 8 is H, or R 8 is selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy and halogen, when R 7 is selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy and halogen; or R 7 , R 8 and the benzene ring to which they are attached are taken together to form a naphthyl group or a benzene ring fused to a heteroaryl group; or R 7 and R 8 are taken together to form a vicinal OC(CH 3 ) 2 O group; and provided that: when R 6 is C(O)Z, wherein Z is OH, X is C(O)NR and R 0 , R, R 1 , R 2 , R 3 , R 4 , R 5 , R 7 and R 8 =H and a=0, 1 or 2, then b=1.