Patent ID: 7592334

Claim:
A compound of formula (I) wherein: Z 1 , Z 3 , and Z 4 are independently N or CR 1a ; Z 2 , Z 5 , and Z 6 are each CR 1a ; R 1 and R 1a are independently at each occurrence hydrogen; cyano; halogen; hydroxy; (C 1-6 )alkoxy unsubstituted or substituted by (C 1-6 )alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is substituted or N-substituted by one or two (C 1-6 )alkyl, acyl, (C 1-6 )alkylsulphonyl, CONH 2 , hydroxy, (C 1-6 )alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C 1-6 )alkylsulphonyloxy; (C 1-6 )alkyl; (C 1-6 )alkylthio; trifluoromethyl; trifluoromethoxy; nitro; azido; acyl; acyloxy; acylthio; (C 1-6 )alkylsulphonyl; (C 1-6 )alkylsulphoxide; arylsulphonyl; arylsulphoxide; or an amino, piperidyl, guanidino or amidino group unsubstituted or N-substituted by one or two (C 1-6 )alkyl, acyl or (C 1-6 )alkylsulphonyl groups; or R 1 and R 1a of Z 2 together form ethylenedioxy; wherein “acyl” is a C(═O)(C 1-13 )alkyl or a C(═O)aryl radical, in which aryl is phenyl or naphthyl; W 1 , W 2 , W 3 , W 4 , W 5 , W 6 , and W 7 are each CR 2 R 3 ; A is a bond, CR 5 R 6 or C═O; R 2 , R 3 , R 4 , R 5 , and R 6 are independently at each occurrence hydrogen; thiol; (C 6 )alkylthio; halogen; trifluoromethyl; azido; (C 1-6 )alkyl; (C 2-6 )alkenyl; (C 1-6 )alkoxycarbonyl; (C 1-6 )alkylcarbonyl; (C 2-6 )alkenylcarbonyl; (C 2-6 )alkenyloxycarbonyl; aralkyl; aryl; heterocyclyl; heterocyclylalkyl; hydroxy; NR 1b R 1b′ ; (C 1-6 )alkylsulphonyl; (C 2-6 )alkenylsulphonyl; or (C 1-6 )aminosulphonyl wherein the amino group is optionally and independently substituted by hydrogen, (C 1-6 )alkyl, (C 2-6 )alkenyl or aralkyl; R 7 is hydrogen; trifluoromethyl; (C 1-6 )alkyl; (C 2-6 )alkenyl; (C 1-6 )alkoxycarbonyl; (C 2-6 )alkenyloxycarbonyl; aryl; aralkyl; (C 3-8 )cycloalkyl; heterocyclyl; or heterocyclylalkyl; R 1b and R 1b ′ are independently at each occurrence hydrogen; (C 1-6 )alkyl; aralkyl; aryl; heterocyclyl; heterocyclylalkyl; or together with the nitrogen to which they are attached form an aziridine, azetidine, pyrrolidine, piperidine or hexamethyleneimine ring (wherein said aziridine, azetidine, pyrrolidine, piperidine or hexamethyleneimine ring are optionally substituted with from 1 to 3 substituents selected from halogen; hydroxy; cyano; nitro; (C 1-6 )alkyl; and aryl); R 8 is UR 9 ; U is CH 2 ; C(C═O); or SO 2 ; R 9 is a group: wherein R 10 is independently: H; (C 1-4 )alkylthio; halo; (C 1-4 )alkyl; (C 2-4 )alkenyl; hydroxy; hydroxy(C 1-4 )alkyl; mercapto(C 1-4 )alkyl; (C 1-4 )alkoxy; trifluoromethoxy; nitro; cyano; carboxy; amino or aminocarbonyl unsubstituted or substituted by (C 1-4 )alkyl; or a pharmaceutically acceptable salt thereof.