Patent ID: 8778888

Claim:
A knottin peptide binding with high affinity to alpha IIb beta 3 integrin, having a sequence at least 90% identical to the sequence selected from the group consisting of: (SEQ ID NO: 1) GCVRLHESCLGQQVPCCDPAATCYCX 1 X 2 RGDX 6 X 7 X 8 X 9 CYCR and (SEQ ID NO: 2) GCIAEDYGRCTWGGTPCCRGRGCICX 1 X 2 RGDX 6 X 7 X 8 X 9 CECT, where X residues are contained in a loop region and X 1 is K, L, R, V, Y or N; X 2 is K or G; X 6 is W, V, M or R; X 7 is R, K or N; X 8 is G, E, S, V, R, M, L, Q, or T; and X 9 is K, R, M or T.