Patent ID: 7087645

Claim:
A method for treating chronic transplant rejection in a mammal comprising administering to said mammal an effective amount of a compound of formula or a pharmaceutically acceptable salt thereof wherein: Y is a bond or R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, hydroxy, C 1-10 alkyl, aryl, heteroaryl, C 1-10 alkaryl, and aryl C 1-10 alkyl, wherein all nonhydrogen and hydroxy substituents may optionally be substituted from one or more of the group selected from C 1-10 alkyl, halogen, nitro, amino, haloC 1-10 alkyl, C 1-10 alkylamino, diC 1-10 alkylamino, acyl, and acyloxy; Z is selected from the group consisting of C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, hydroxyC 1-10 alkyl, aryl, heteroaryl, C 1-10 alkaryl, arylC 1-10 alkyl, heteroarylC 1-10 alkyl, C 1-10 alkoxyC 1-10 alkyl, C 1-10 alkylaminoC 1-10 alkyl, carboxyC 1-10 alkyl, C 1-10 dialkylaminoC 1-10 alkyl, aminoC 1-10 alkyl, heterocycle, heterocyclC 1-10 alkyl, R 7 NH, R 7 R 7 N, carboxy, carbohydrate group, carbohydrate lactone group, and an alditol group wherein all may optionally be substituted by one or more R 5; R 5 is independently selected from the group selected from hydroxy, C 1-10 alkyl, C 1-10 alkoxy, halo, nitro, amino, cyano, C 1-10 alkylamino, diC 1-10 alkylamino, acyl, acyloxy, COOH, COOR 7 , OC(O)R 7 , CH(OH)R 7 , NHR 7 , NR 7 R 7 , C(O)NH 2 , C(O)NHR 7 , CONR 7 R 7 , NHC(O)O—R 7 , OSO 3 H, SO 3 H, SO 2 NHR 7 , SO 2 NR 7 R 7 , P(O)(OH)OR 7 , PO 2 H 2 P(O)(OH)R 7 , P(O)(OR 7 ) 2 , P(O)R 7 (OR 7 ), OPO 3 H, PO 3 H 2 , hydroxymethyl, and cyclic phosphate, wherein when possible, all may be optionally substituted by one or more R 6 ; R 6 is independently selected from the group consisting of hydroxy, C 1-10 alkyl, C 1-10 alkoxy, acyloxy, halo, nitro, amino, cyano, haloC 1-10 alkyl, C 1-10 alkylamino, diC 1-10 alkylamino, acyl, and acyloxy; R 7 is independently selected from the group consisting of C 1-10 alkyl, C 1-10 alkenyl, C 1-10 alkynyl, C 1-10 alkoxy, C 1-10 alkoxycarbonylC 1-10 alkyl, aryl, carboxyC 1-10 alkyl, C 1-10 alkylcarboxyC 1-10 alkyl, C 1-10 alkylcarboxyC 1-10 aryl, heterocycle, heterocyclC 1-10 alkyl, and heteroaryl, wherein all may be optionally substituted by one or more R 8 ; and R 8 is independently selected from the group consisting of hydroxy, C 1-10 alkyl, C 1-10 alkoxy, acyloxy, halo, nitro, amino, cyano, and carboxy; wherein two R 7 groups may come together to form a 4 to 7 membered ring.