Patent ID: 7638638

Claim:
A compound of the formula: wherein n is 1; X and Y are each independently selected from the group consisting of —C(O)—, —C (S)—, —C(NR 34 )—, —S(O)—, and —S(O) 2 — where R 34 is hydrogen or an alkyl, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; Z is a 2-cyano-pyrrolidin-1-yl; R 1 and R 2 are each hydrogen; R 3 is selected from the group consisting of hydrogen, (C 1-10 )alkyl, hydroxy, alkoxy, and amino, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; R 5 and R 6 are each independently selected from the group consisting of hydrogen, (C 1-10 )alkyl, alkoxy, cyano, halo, and nitro, wherein said alkyl and alkoxy groups are unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties; and R 7 is amino, unsubstituted or substituted with one or more substituents selected from the group consisting of aldehyde, alkyl, alkylene, alkylidene, amide, amino, aminoalkyl, aryl, bicycloalkyl, bicycloaryl, carbamoyl, cycloalkyl, cycloalkylene, ester, halo, heterobicycloalkyl, heterocycloalkylene, heteroaryl, heterobicycloaryl, heterocycloalkyl, oxo, hydroxy, iminoketone, ketone, nitro, oxaalkyl, and oxoalkyl moieties.