Patent ID: 7935530

Claim:
A polyamide-tail conjugate comprising a tail linked to a polyamide, wherein said polyamide is capable of binding DNA with an affinity of less than 100 nM, and wherein said tail comprises a linker and an end-group, and (a) wherein said linker is a C 2-12 alkyl or has a structure of (R 1 (CR 2 R 3 )hR 4 )i; where R 1 and R 4 are independently selected from NH and O; where R 2 and R 3 are independently selected from H, OH, F, Cl, Br, I, NO 2 , NH 2 , CF j H k , OCF j H k , COOH, CONH 2 , CONR′R″; where R′ and R″ are independently selected from H, methyl, ethyl, CF j H k , C 2 F n H m , F, Cl, Br, I, CN, CF 3 , CCl 3 , CBr 3 , Cl 3 , NO 2 , COOCF j H k , (OPO 3 ) 2− , OCOCH 3 , OCOCF j H k , OMe, OEt, OCF j H k , NH 2 , NR 6 R 7 ; where R 6 and R 7 may be H or C 1-3 alkyl; and where j+k=3, n+m=5, and n or m may be 0; and where h and i are independently selected from any integer from 1 to 4; (b) wherein said end-group is selected from the group consisting of isophthalic acid; phthalic acid; terephthalic acid; morpholine; N,N-dimethylbenzamide; N,N-bis(trifluoromethyl)benzamide; fluorobenzene; (trifluoromethyl)benzene; nitrobenzene; phenyl acetate; phenyl 2,2,2-trifluoroacetate; phenyl dihydrogen phosphate; 2H-pyran; 2H-thiopyran; benzoic acid; isonicotinic acid; and nicotinic acid; where one, two or three ring members in any of these end-group candidates may be independently substituted with C, N, S or O; and where any one, two, three, four or five of the hydrogens bound to the ring may be substituted with R 5 , wherein R 5 may be independently selected for any substitution from H, OH, F, Cl, Br, I, NO 2 , NH 2 , CF j H k , OCF j H k , COOH, CONH 2 ; CONR′R″; where R′ and R″ need not be the same group and can be H, methyl, ethyl, CF j H k , C 2 F n H m , F, Cl, Br, I, CN, CF 3 , CCl 3 , CBr 3 , Cl 3 , NO 2 , COOCF j H k , (OPO 3 ) 2− , OCOCH 3 , OCOCF j H k , OMe, OEt, OCF j H k , NH 2 , NR 6 R 7 ; where R 6 and R 7 may be H or C 1-3 alkyl; and where j+k=3, n+m=5, and n or m may be 0.