Patent ID: 8629141

Claim:
A compound having Formula I: wherein: R 1a , R 1b , R 1c , and R 1d are independently selected from the group consisting of hydrogen, halogen, hydroxy, amino, nitro, cyano, alkoxy, aryloxy, optionally substituted alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, carboxamido, and sulfonamido; R 2 is selected from the group consisting of optionally substituted aryl and optionally substituted heteroaryl; R 3a is halo; R 3b is halo; or R 3a and R 3b taken together form a 3- to 9-membered optionally substituted cycloalkyl or a 3- to 9-membered optionally substituted heterocyclo; E is selected from the group consisting of —OR 26a and —NR 26b R 26c ; R 26a is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted aryl; R 26b is selected from the group consisting of hydrogen and optionally substituted C 1 -C 6 alkyl; R 26c is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo, optionally substituted aryl, optionally substituted heteroaryl, aralkyl, and —SO 2 R 5b ; or R 26b and R 26c taken together form a 4- to 9-membered optionally substituted heterocyclo; X is selected from the group consisting of O, S, and NR′; Y is selected from the group consisting of O, S, and NR″; R′ is selected from the group consisting of hydrogen, optionally substituted alkyl, aralkyl, and optionally substituted cycloalkyl; R″ is selected from the group consisting of hydrogen, optionally substituted alkyl, aralkyl, and optionally substituted cycloalkyl; and represents a single or a double bond, or a pharmaceutically acceptable salt thereof.