Patent ID: 6964764

Claim:
A method of administering a therapeutic dose of a reversibly inactivated acidified mammalian serine protease composition to a human or animal having a thrombotic occlusion, comprising the steps of: a) identifying a human or animal having a thrombotic occlusion; and b) administering parenterally to the human or animal a therapeutic dose of a pharmaceutically acceptable reversibly inactivate acidified mammalian serine protease composition substantially free o plasminogen activator, wherein the therapeutic dose is delivered into or proximally to the thrombotic occlusion; wherein the mammalian serine protease composition comprises a low buffering capacity buffer and has a pH less than about 4.0, and wherein the composition is a pharmaceutically acceptable solution that can be raised to a physiological pH by adding no more than about 5 volumes of serum to the solution relative to the volume of solution.