Patent ID: 8809552

Claim:
A compound of Formula (I): R 1 -L 1 -A-L 2 -R 2 (I) wherein: A is wherein X is NH or CH2; Y is N or CH; L 1 is selected from the group consisting of a bond, —(CH 2 ) 1-3 —, —NH—(CH 2 ) 0-3 —C(O)—, —(CH 2 ) 0-3 —C(O)—, —(CH 2 ) 0-3 —SO 2 — and —(CH 2 ) 0-3 —NR 3 —C(O)—; L 2 is selected from the group consisting of a bond, —(CH 2 ) 1-3 —, —(CH 2 ) 0-3 —C(O)—NH—,—NH—(CH 2 ) 0-3 —C(O)—NH—,—(CH 2 ) 0-3 —C(O)—, —(CH 2 ) 0-3 —SO 2 — and —(CH 2 ) 0-3 —NR 3 —C(O)—; R 1 is selected from the group consisting of phenyl, 5- or 6-membered heteroaryl, adamantyl and —(CH 2 ) 1-3 -phenyl, wherein said phenyl, heteroaryl or adamantyl is unsubstituted or substituted by one to three R 5 groups; R 2 is selected from the group consisting of phenyl, 5- or 6-membered heteroaryl and —(CH 2 ) 1-3 -phenyl, wherein said phenyl or heteroaryl is unsubstituted or substituted by one to three R 5 groups; R 3 is hydrogen or lower alkyl; R 4 is hydrogen or lower alkyl; and R 5 is selected from the group consisting of halogen, lower alkyl, lower haloalkyl, lower haloalkoxy, and —C(O)OR 4 , or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, with the proviso that said compound is not (4-bromophenyl)[6-[(4-methylphenyl)sulfonyl]-1,6-diazaspiro[3,3]hept-1-yl]methanone, 6-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-1,6-diazaspiro[3,3]heptane, 2,6-bis[(4-methylphenyl)sulfonyl]-2,6-diazaspiro[3,3]heptane or 2-phenyl-6-(phenylmethyl)-2,6-diazaspiro[3,3]heptane, and the further provisos that when L 2 is —C(O)—NH—, L 1 is not —CH 2 —; when L 2 is —CH 2 —, L 1 is not a bond; when L 2 is —SO 2 —, L 1 is not —CH 2 —; and L 1 and L 2 are different.