Patent ID: 7648996

Claim:
A compound having the formula (I): wherein: X represents bond or CH 2 ; R 1 represents a keto group or (H,H); R 2 represents OH or OMe; R 3 represents H, OH or OMe; R 4 and R 5 each independently represent H or OH; R 6 represents —R 7 , —C(O)R 7 , —(CH 2 ) 2 —O—[CR 21 R 22 —O] a —C(O)—R 23 ; —CR 21 R 22 —O—C(O)—R 23 ; —POR 19 R 20 , —PO(OR 19 )(OR 20 ) or Y—R 15 ; R 7 represents —(CR 8 R 9 ) m (CR 10 R 11 ) p CR 12 R 13 R 14 ; R 8 and R 9 each independently represent C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of which groups may optionally be substituted with —PO(OH) 2 , —CF 2 PO(OH) 2 , —OH, —COOH or —NH 2 ; or R 8 and R 9 each independently represent H, trifluoromethyl or F; R 10 , R 11 , R 12 , R 13 and R 14 each independently represent C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of which groups may optionally be substituted with —PO(OH) 2 , —CF 2 PO(OH) 2 , —OH, —COOH or —NH 2 ; or R 10 , R 11 , R 12 , R 13 and R 14 may be independently selected from H, —(CR 8 R 9 ) q NH 2 , —(CR 8 R 9 ) q OH, CF 3 , F, COOH; or R 10 and R 11 or R 12 and R 13 or R 13 and R 14 may be taken together with the carbon to which they are joined to form a C3-C6 cycloalkyl or a 3- to 6-membered heteroalkyl ring that contains one or more heteroatoms selected from N, O and S and that is optionally, substituted with up to 5 —(CR 8 R 9 ) q OH, —(CR 8 R 9 ) q NH 2 or COOH groups; Y=bond, —C(O)—O—; —(CH 2 ) 2 —O—C(O)—O—; R 15 represents R 16 are each independently H or OH; R 17 is independently selected from H, OH and NH 2 ; R 18 is independently selected from H, —CH 3 , —CH 2 OH and —COOH; provided however that no more than 2 groups selected from R 16 , R 17 and R 18 represent H or CH 3 ; R 19 and R 20 each independently represent H or C1-C4 alkyl or R 19 and R 20 together represent ═CH 2 ; R 21 is independently selected from H, CH 3 ; R 22 is independently selected from H, —CH 3 , —CH═CH 2 , —CH 2 Cl, —CHCl 2 , —CCl 3 , —CH(OH)Me, —CH 2 OH, —CH 2 CH 3 , —CH(Cl)Me; R 23 is independently R 7 , Y—R 15 or a 5- or 6-membered aryl or heteroaryl ring optionally substituted with between one and three groups selected from OH, F, Cl, Br, NO 2 and NH 2 ; a represents 0 or 1; m, p and q each independently represent an integer between 0-4; provided however that the R 7 moiety does not contain more than 12 carbon atoms and does contain at least one functional group selected from —PO(OH) 2 , —CF 2 PO(OH) 2 , —COOH, OH or NH 2 ; or a pharmaceutically acceptable salt thereof.