Patent ID: 8664216

Claim:
A compound of formula (I) wherein X—Y is C(R a R b )—O, wherein R a and R b are each independently H or C 1-4 -alkyl, C(R c R d )—S(O) p , wherein R c and R d are each independently H or C 1-4 -alkyl, C(O)O, CH 2 OCH 2 , or CH 2 CH 2 O; Z is CH or N; R 1 is halo, cyano, C 1-4 -alkoxy, or C 1-4 -alkyl; R 2 is H, C 1-12 -alkyl, unsubstituted or substituted with one or more OH, halo, cyano or C 1-12 -alkoxy, —(CH 2 ) q —R e , wherein R e is phenyl or 5- or 6-membered heteroaryl, each unsubstituted or substituted with one or more substituents independently selected from A, —CH 2 ) r NR i R ii , —C(O)—C 1-12 -alkyl, wherein C 1-12 -alkyl is unsubstituted or substituted with one or more OH, halo, cyano or C 1-12 -alkoxy, —C(O)(CH 2 ) q OC(O)—C 1-12 -alkyl, —C(O)(CH 2 ) q NR i R ii , —C(O)O—C 1-12 -alkyl, wherein alkyl is unsubstituted or substituted with one or more OH, halo, cyano or C 1-12 -alkoxyl, —S(O) 2 —C 1-12 -alkyl, or —S(O) 2 NR i R ii ; R i and R ii are each independently H or C 1-12 -alkyl, or together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl containing one or two heteroatoms selected from N, O and S, which heterocycloalkyl is unsubstituted or substituted by one or more substituents independently selected from B; A is halo, cyano, OH, C 1-7 -alkyl, halo-C 1-7 -alkyl, or C 1-7 -alkoxy; B is oxo, halo, OH, C 1-7 -alkyl or C 1-7 -alkoxy; R 3 is Cl or F; n is 1 or 2; m is 0, 1, 2, 3 or 4; p is 0, 1 or 2; q is 1, 2, 3 or 4; and r is 2, 3 or 4, or a pharmaceutically acceptable salt thereof.