Patent ID: 7635468

Claim:
A human tumor cell transfected ex-vivo with nucleic acid molecules encoding: a) interleukin-7 (IL-7), granulocyte-macrophage colony stimulating factor (GM-CSF), CD40L/CD154 and B7.1/CD80, or b) interleukin-7 (IL-7), granulocyte-macrophage colony stimulating factor (GM-CSF), and CD40L/CD154 and comprising the corresponding expression constructs, wherein the expression construct is: a) a plasmid; or b) a linear double stranded, covalently closed expression cassette comprising essentially solely a CMV promoter, an intron the encoding gene sequence and a poly adenylation sequence being closed on both ends of the double strand by a short loop of single strands nucleotide residues, wherein said tumor cell is an allogeneic tumor cell of a renal cell carcinoma cell line deposited under accession number DSM ACC 2635 at the DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH.