Patent ID: 7626012

Claim:
An isolated nucleic acid molecule comprising nucleic acid sequence(s) encoding a human monoclonal antibody or an antigen-binding portion thereof that specifically binds to and activates human CD40, wherein the heavy chain and the light chain of said antibody comprise the heavy chain CDR1, CDR2 and CDR3 amino acid sequences and the light chain CDR1, CDR2 and CDR3 amino acid sequences, respectively, of an antibody selected from the group consisting of: 3.1.1 (ATCC Deposit No. PTA-3600), 7.1.2 (ATCC Deposit No. PTA-3601), 10.8.3 (ATCC Deposit No. PTA-3602), 15.1.1 (ATCC Deposit No. PTA-3603), 21.4.1 (ATCC Deposit No. PTA-3605), 21.2.1 (ATCC Deposit No. PTA-4549), 22.1.1 (ATCC Deposit No. PTA-4550), 23.5.1 (ATCC Deposit No. PTA-4548), 23.25.1 (ATCC Deposit No. PTA-4551), 23.28.1 (ATCC Deposit No. PTA-4552), 23.29.1 (ATCC Deposit No. PTA-4553) and 24.2.1 (ATCC Deposit No. PTA-4554).