Patent ID: 8716464

Claim:
A composition comprising: (a) a first siRNA that silences Ebola virus L-pol expression, wherein the first siRNA consists of the following sense and antisense strand sequences: (SEQ ID NO: 2) 5′-G U AC G AAGC UGU A U A U AAATT-3′ (SEQ ID NO: 6) 3′-TTCA U GCU U CGACAUA U AUUU-5′, wherein the bolded and underlined nucleotides are 2′OMe nucleotides; and (b) a second siRNA that silences Ebola virus VP35 expression, wherein the second siRNA consists of the following sense and antisense strand sequences: (SEQ ID NO: 26) 5′- G CAAC U CAU U G G ACA U CA UU C-3′ (SEQ ID NO: 30) 3′-A U CG U U G AGUAACCU G UAG U A-5′, wherein the bolded and underlined nucleotides are 2′OMe nucleotides.