Patent ID: 7923450

Claim:
A compound of formula I wherein R 1 is —C(O)O-lower alkyl or cyano or is selected from the group consisting of pyridine-4-yl, thiazole-5-yl, oxazol-5-yl, [1,2,4]triazol-1-yl, imidazol-1-yl, pyrazol-4-yl, [1,2,4]oxadiazol-5-yl, [1,3,4]-oxadiazol-2-yl, and [1,2,4]-thiadiazol-5-yl, optionally substituted by R′; R′ is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or lower alkoxy substituted by halogen; R 2 is hydrogen, lower alkoxy, lower alkyl, halogen or cyano; R 3 is —(CH 2 ) n —C(O)O-lower alkyl, lower alkoxy, hydroxy, —O—Si(CH 3 ) 2 -lower alkyl, —C(O)—N(lower alkyl) 2 , —O—S(O) 2 -lower alkyl, C 3-7 -cycloalkyl, S(O) 2 -aryl, or is heterocyclyl or —C(O)-heterocyclyl, wherein the heterocyclyl group is pyrrolidinyl, piperidinyl, or morpholinyl, or is aryl or hetaryl, wherein aryl is phenyl, hetaryl is pyridyl or [1,2,4]oxadiazole-5-yl and wherein the aryl and hetaryl rings are optionally substituted by one or more R′; R 4 is hydrogen, lower alkyl, hydroxy or CH 2 CN; X is S or —N═C(R 5 )—; R 5 is hydrogen, lower alkyl or hydroxy, Y is a bond, —O—, —CH 2 —, —CH 2 —CH 2 —, or —N(R)—; R is hydrogen, lower alkyl, C(O)O-lower alkyl, C(O)-lower alkyl, S(O) 2 -lower alkyl, or benzyl; and n is 0 or 1; or a pharmaceutically active acid addition salt thereof.