Patent ID: 7662856

Claim:
An anti-mycobacterial composition comprising a therapeutically effective amount of at least one compound of the formula (I): or pharmaceutically acceptable salts thereof and at least one hydroxylamine having the formula (II): H 2 N—OR (II) where: R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of hydrogen, linear or branched lower alkyl, linear or branched lower alkenyl, linear or branched lower alkynyl, linear or branched aryl lower alkyl, linear or branched aryl, linear or branched heterocyclic lower alkyl, linear or branched heterocyclic lower cycloalkyl, linear or branched lower cycloalkyl, linear or branched lower cycloalkyl lower alkyl and mixtures or combinations thereof; E is selected from the group consisting of CR 5 (R 6 ), CH 2 CR 5 (R 6 ), and CR 5 (R 6 )CH 2 , where R 5 and R 6 are independently selected from the group consisting of hydrogen, linear or branched lower alkyl, linear or branched lower alkenyl, linear or branched lower alkynyl, linear or branched aryl lower alkyl, linear or branched aryl, linear or branched heterocyclic lower alkyl, linear or branched heterocyclic lower cycloalkyl, linear or branched lower cycloalkyl, linear or branched lower cycloalkyl lower alkyl and mixtures or combinations thereof; E′ is selected from the group consisting of O, S, or NR 7 ; E″ is O; n is an integer having a value between 1 and 4; and R is selected from the group consisting of an hydrogen atom, a C1 alkyl group, C2 alkyl group, C3 alkyl group and C4 alkyl group.