Patent ID: 8017620

Claim:
A compound of the formula II: where R 1 is H, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl or a 5 or 6 membered, saturated or unsaturated ring containing 0 to 3 heteroatoms selected from N, O and S, the alkyl, alkenyl, alkynyl or ring being independently optionally substituted with R 4 ; D is —NR 5 —; R 4 is hydrogen, halo, cyano, amino, nitro, carboxy, carbamoyl, hydroxy, oxo, C 1 -C 5 alkyl, C 1 -C 5 haloalkyl, C 1 -C 5 alkyloxy, C 1 -C 5 alkanoyl, C 1 -C 5 alkanoyloxy, C 1 -C 5 alkylthio, —N(C 0 -C 3 -alkyl) 2 , hydroxymethyl, aminomethyl, carboxymethyl; —SO 2 N(C 0 -C 3 -alkyl), —SO 2 C 1 -C 5 -alkyl; R 5 is H, C 1 -C 4 -alkyl, C 1 -C 4 -alkanoyl; E is Si or C; R 6 and R 7 are independently selected from a stable monocyclic, bicyclic or tricyclic ring system which has an aromatic nature wherein each ring has 0 to 3 heteroatoms selected from N, O and S R 8 is selected from C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or a stable monocyclic, bicyclic or tricyclic ring system which is saturated or unsaturated in which each ring has 0 to 3 heteroatoms selected from N, O and S; R 6 , R 7 and R 8 are independently optionally substituted with R 4 ; G is —O—, —S—, —CHR 10 —, —C(═O)—; J is —CH 2 —, or when G is CHR 10 may also be —O— or —NH—; R 10 is H, F, —CH 3 , —CH 2 NH 2 , —CH 2 OH, —OH; or a pharmaceutically acceptable ether, amide or ester thereof; R 11 is H, F, —CH 3 , —CH 2 NH 2 , —CH 2 OH, CH(OH)CH 3 , CH(NH 2 )CH 3 or a pharmaceutically acceptable ether, amide or ester thereof; or R 10 and R 11 together define an olefinic bond, or together form a —CH 2 -group, thereby defining a cis or trans cyclopropyl group; and pharmaceutically acceptable salts thereof.