Patent ID: 8758334

Claim:
A neuromodulation device for hepatic neuromodulation, comprising: a catheter body comprising a proximal end and a distal end, wherein the body is configured for intravascular delivery within a tortuous arterial branch supplying blood to a liver of a subject; an articulatable portion at the distal end of the body; and at least one articulation member being coupled to the articulatable portion and extending from the articulatable portion toward the body, wherein the at least one articulation member is configured to effect a change in linear shape of the articulatable portion at the distal end of the body, wherein the articulatable portion comprises at least one radiofrequency (RF) electrode, wherein the articulatable portion is configured to apply and maintain contact pressure between the at least one RF electrode and a target location of an inner wall of the tortuous arterial branch, thereby facilitating continuous contact as the tortuous arterial branch moves in response to diaphragm motion, wherein the contact pressure is between 0.1 g/mm 2 and 100 g/mm 2 , and wherein the at least one RF electrode is configured to be activated to deliver RF energy to the target location sufficient to achieve denervation of the tortuous arterial branch, thereby decreasing a blood glucose level within the subject.