Patent ID: 7354905

Claim:
A pharmaceutical formulation comprising an effective amount of acetylsalicylic acid and a compound of formula I, R 1 O(O)Câ€”CH 2 â€”(R)Cgl-Aze-Pab-R 2 I wherein R 1 represents â€”R 3 or -A 1 (O)N(R 4 )R 5 in which A 1 represents C 1-3 alkylene or -A 1 C(O)OR 4 in which A 1 represents C 1-5 alkylene; R 2 (which replaces one of the hydrogen atoms in the amidino unit of Pab-H) represents OH, OC(O)R 6 , C(O)OR 7 or C(O)OCH(R 8 )OC(O)R 9 ; R 3 represents H, C 1-10 alkyl, or C 1-3 alkylphenyl (which latter group is optionally substituted by C 1-6 alkyl, C 1-6 alkoxy, nitro or halogen); R 4 and R 5 independently represent H, C 1-6 alkyl, phenyl, 2-naphthyl or, when R 1 represents -A 1 C(O)N(R 4 )R 5 , together with the nitrogen atom to which they are attached represent pyrrolidinyl or piperidinyl; R 6 represents C 1-17 alkyl, phenyl or 2-naphthyl (all of which are optionally substituted by C 1-6 alkyl or halogen); R 7 represents 2-naphthyl, phenyl, C 1-3 alkylphenyl (which latter three groups are optionally substituted by C 1-6 alkyl, C 1-6 alkoxy, nitro or halogen), or C 1-12 alkyl (which latter group is optionally substituted by C 1-6 alkoxy, C 1-6 acyloxy or halogen); R 8 represents H or C 1-4 alkyl; and R 9 represents 2-naphthyl, phenyl, C 1-6 alkoxy or C 1-8 alkyl (which latter group is optionally substituted by halogen, C 1-6 alkoxy or C 1-6 acyloxy); provided that: when R 1 represents R 3 , R 3 represents benzyl, methyl, ethyl, n-butyl or n-hexyl and R 2 represents C(O)OR 7 , then R 7 does not represent benzyl; or a pharmaceutically-acceptable salt thereof.