Patent ID: 8858967

Claim:
A topically applicable pharmaceutical/dermatological composition, said composition being a cream-gel comprising ivermectin and an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, said ivermectin being solubilized in a solvent and/or propenetrating agent selected from the group consisting of propylene glycol, ethanol, isopropanol, butanol, benzyl alcohol, N-methyl-2-pyrrolidone, DMSO, polysorbate 80, phenoxyethanol, and mixtures thereof, said non-surfactant polymeric emulsifier being an acrylate/C 10 -C 30 alkyl acrylate crosspolymer, said non-surfactant polymeric emulsifier and a carbomer being dispersed in said aqueous phase, said composition further comprising a co-emulsifier selected from the group consisting of polysorbate 80, sorbitan laurate and poloxamer 124, said non-surfactant polymeric emulsifier and said co-emulsifier being the only emulsifiers in the composition, said oily phase amounting to 8 to 15% by weight of the composition, said oily phase comprising liquid oils having a melting point below 30° C. and having less than 0.1% by weight of waxes, fatty acids and fatty alcohols having a melting point above 30° C., that are in the solid state at ambient temperature, formulated into a topically applicable, physiologically acceptable medium therefor, said cream-gel having less than 0.1% by weight of waxes, fatty acids and fatty alcohols having a melting point above 30° C., that are in the solid state at ambient temperature, said cream-gel being physically and chemically stable for a period of 12 weeks.