Patent ID: 8318719

Claim:
A compound of Formula I, wherein: Q 1 is NH or O; Q 2 is N or C(Y 6 ); R is H, —R 1 , —R 1 -R 2 -R 3 , —R 1 -R 3 , or —R 2 -R 3 ; R 1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, and is optionally substituted with one or more lower alkyl, hydroxy, hydroxy lower alkyl, lower alkoxy, halo, nitro, amino, amido, R 2′ NC(═O), cyano, oxo, or halo-lower alkyl; R 2 is —C(═O), —C(═O)O, —C(═O)NR 2′ , —NHC(═O)O, —C(═NH)NR 2′ , or —S(═O) 2 ; R 2′ is H or lower alkyl; R 3 is H or R 4 ; R 4 is lower alkyl, amino, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl, and is optionally substituted with one or more lower alkyl, hydroxy, lower alkoxy, hydroxy lower alkyl, hydroxy lower alkoxy, lower alkyl sulfonyl, lower alkyl sulfonamido, carbamate, carboxy, lower alkyl-OC(═O)—, lower alkyl-C(═O)O—, R 2′ NC(═O), acyl, halo, nitro, amino, cyano, oxo, or halo-lower alkyl; X is CH or N; Y 1 is H, lower alkyl, or lower haloalkyl; Y 2 is Y 2a or Y 2b ; Y 2a is H or halogen; Y 2b is lower alkoxy or lower alkyl, optionally substituted with one or more Y 2b′ ; Y 2b′ is hydroxy or halogen; each Y 2′ is independently Y 2′a or Y 2′b ; Y 2′a is halogen or hydroxy; Y 2′b is lower alkoxy or lower alkyl, optionally substituted with one or more Y 2′b′ ; Y 2′b′ is hydroxy or halogen; p is 0, 1, or 2; Y 3 is Y 3a or Y 3b ; Y 3a is halogen or hydroxy; Y 3b is lower alkoxy or lower alkyl, optionally substituted with one or more substituents selected from the group consisting of hydroxy, lower alkoxy, amino, and halogen; m is 0 or 1; Y 4 is Y 4a , Y 4b , Y 4c , or Y 4d ; Y 4a is hydroxy or halogen; Y 4b is lower alkoxy or lower alkyl, optionally substituted with one or more substituents selected from the group consisting of lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy; Y 4c is lower cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy; Y 4d is amino, optionally substituted with one or more lower alkyl, alkoxy lower alkyl, or hydroxy lower alkyl; Y 5 is halogen, hydroxy, lower alkyl, lower alkoxy, lower haloalkoxy, lower hydroxyalkyl, or lower haloalkyl; and Y 6 is H, hydroxy, halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower alkylthio, amino, or lower hydroxyalkyl; or a pharmaceutically acceptable salt thereof.