Patent ID: 8003111

Claim:
A PEGylated interferon-α(IFN-α) complex comprising: a) a PEG (polyethylene glycol) moiety comprising PEG covalently attached to a first peptide; and b) a fusion protein comprising IFN-α and a second peptide attached to the C-terminal end of IFN-α; wherein two copies of second peptide form a dimer that binds to the first peptide to form a PEGylated IFN-α complex wherein the amino acid sequence of the second peptide is selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2, and the amino acid sequence of the first peptide is selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9.