Patent ID: 8624022

Claim:
A compound having the structure of Formula I: wherein, n is 0, 1, or 2; R 1 and R 2 are independently selected from H, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 2 -C 6 )heteroalkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 2 -C 8 )heterocycloalkyl, (C 2 -C 8 )heterocycloalkenyl, aryl, and heteroaryl, wherein the (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 2 -C 6 )heteroalkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 2 -C 8 )heterocycloalkyl, (C 2 -C 8 )heterocycloalkenyl, aryl, and heteroaryl are each optionally substituted with 1 or 2 independently selected R x groups; Ar is phenyl or naphthyl, either of which is substituted with a phenyl, O-phenyl, or OCH 2 -phenyl in which the phenyl group is further optionally substituted with 1 or 2 independently selected R x groups; R 3 is L 1 -L 2 -R 4 , where L 1 is a bond, O, NR 1 , or S; L 2 is a bond, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 2 -C 6 )heteroalkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 2 -C 8 )heterocycloalkyl, or (C 2 -C 8 )heterocycloalkenyl; and R 4 is H, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, or aryl, wherein the cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, and aryl are each optionally substituted with 1 or 2 independently selected R x groups; R x is L s1 L s2 R s , wherein each L s1 and L s2 is independently a bond, —O—, —C(═O)—, —S—, —S(═O)—, —S(═O) 2 —, —NH—, —NHC(O)—, —C(O)NH—, S(═O) 2 NH—, —NHS(═O) 2 , —OC(O)NH—, —NHC(O)O—, (C 1 -C 6 ) alkyl, or —(C 2 -C 6 ) alkenyl; and R s is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, alkylsulfoxide, arylsulfoxide, alkylsulfone, arylsulfone, cyano, halo, isocyanato, thiocyanato, isothiocyanato, nitro, perhaloalkyl, perfluoroalkyl, silyl or amino, including mono- and di-substituted amino groups; or a pharmaceutically acceptable salt, solvate, or tautomer thereof.