Patent ID: 6932969

Claim:
An Ig fraction obtained by a method comprising a) preparing an insoluble support onto which is grafted a component selected from the group consisting of polyvalent IgGs, polyvalent IgMs and DNP-lysine, b) adsorbing polyvalent Igs onto the support obtained in step a), c) eluting the Igs retained on a portion of immunoglobulins bound to the support, so as to collect a first intermediate fraction connected through IgG-IgG or IgM-IgG idiotypic interactions, or eluting a second intermediate fraction which interacts with DNP, d) selecting from the first or the second intermediate fraction a third intermediate fraction having reactivity with IgMs, IgG F(ab′)2s or DNP, little or no reactivity with non-self antigens and/or polyreactivity with autoantigens, and e) selecting from the third intermediate fraction the Ig fraction having activity which inhibits a proliferation of lymphocytes in mixed culture.