Patent ID: 8404458

Claim:
A method comprising: a) providing a candidate compound; b) providing a chromatin binding protein; c) contacting i) the candidate compound and ii) the chromatin binding protein with iii) a histone comprising a serine or threonine within three amino acids from an arginine amino acid capable of being methylated or a lysine amino acid capable of being methylated, acetylated, ubiquitinated, or SUMOylated; d) measuring both i) the binding of the chromatin binding protein to the histone and ii) phosphorylation of the histone, in the presence and absence of the candidate compound; and e) identifying, based on said measuring, the candidate compound that either i) decreases the binding of the chromatin binding protein to the histone and increases the serine or threonine phosphorylation of the histone or ii) increases the binding of the chromatin binding protein to the histone and decreases the serine or threonine phosphorylation of the histone, thereby identifying the candidate compound which increases or decreases the binding of the chromatin binding protein to the histone.