Patent ID: 7078419

Claim:
A compound of the formula (I) wherein: Ar 1 is chosen from phenyl, naphthyl, tetrahydronaphthyl, indanyl and indenyl, each Ar 1 is optionally substituted with one R 1 , and wherein Ar 1 is independently substituted with two R 2 groups; R 1 is halogen, NO 2 , NH 2 , J-N(R a )—(CH 2 ) m —, N(J) 2 —(CH 2 ) m —, NH 2 C(O)—, J-N(R a )—C(O)—, J-S(O) m —N(R a )—, J-N(R a )—S(O) m —; Q is CR p ; Y is —N(R x )—; wherein R a , R p , R v , R x and R y are each independently hydrogen or C 1-5 alkyl; X is —CH 2 —, —N(R a )—, —O— or —S—; W is CH; each m is independently 0,1 or 2; J is C1–10 alkyl optionally substituted by R b ; R 2 is chosen from C1–6 alkyl, C3–7 cycloalkyl optionally substituted by C1–5 alkyl, C1–4 acyl, aroyl, C1–4 alkoxy, each being optionally partially or fully halogenated, halogen, C1–6 alkoxycarbonyl, carbocyclesulfonyl and —SO 2 —CF 3 ; each R 3 , R 4 and R 5 are independently chosen from hydrogen, C1–6 alkyl and halogen; R 6 is optionally attached at a position ortho or meta to the N atom of the indicated ring, and is chosen from a bond, —O—, —O—(CH 2 ) 1-5 —, >C(O), —NH—, —C(O)—NH—, —S—, C 1-5 alkyl branched or unbranched, C 2-5 alkenyl, C 1-3 acyl, C 1-3 alkyl(OH), aryl each alkyl, alkenyl, acyl and aryl are optionally substituted by one to three hydroxy, oxo, C 1-3 alkyl, C 1-3 alkoxy, C 1-5 alkoxycarbonyl, —NR 7 R 8 or NR 7 R 8 —C(O)—; wherein each R 6 is further optionally covalently attached to groups chosen from: hydrogen, —NR 7 R 8 , C 1-3 alkyl, C 3-6 cycloalkylC 0-2 alkyl, hydroxy, C 1-3 alkoxy, phenoxy, benzyloxy, arylC 0-4 alkyl, each aryl group is optionally substituted by one to three hydroxy, oxo, C 1-4 alkyl, C 1-3 alkoxy, C 1-5 alkoxycarbonyl, NR 7 R 8 —C(O)— or C 1-4 acyl; each R 7 and R 8 are independently hydrogen, phenylC 0-3 alkyl optionally subtituted by halogen, C 1-3 alkyl or diC 1-5 alkyl amino, or R 7 and R 8 are C 1-2 acyl, benzoyl or C 1-5 branched or unbranched alkyl optionally substituted by C 1-4 alkoxy, hydroxy or mono or diC 1-3 alkyl amino; and R b is chosen from hydrogen, C1–5 alkyl, hydroxyC1–5 alkyl, C2–5 alkenyl, C2–5 alkynyl, carbocycle, C1–5 alkoxy, C1–5 alkylthio, amino, C1–5 alkylamino, C1–5 dialkylamino, C1–5 acyl, C1–5 alkoxycarbonyl, C1–5 acyloxy, C1–5 acylamino, each of the aforementioned are optionally partially or fully halogenated, or R b is chosen from C1–5 alkylsulphonylamino, hydroxy, oxo, halogen, nitro and nitrile; or the pharmaceutically acceptable salts, acids or isomers thereof.