Patent ID: 8299057

Claim:
A compound of formula (I): wherein: X is —CH 2 —, —CH(OH)—, —CH(OR′)— or —C(R′R″)—, wherein: R′ is C 1 -C 6 alkyl and R″ is hydrogen; Ar is phenyl, pyrazolyl or pyridyl optionally substituted with one or more substituents independently selected from halogen, nitro, COR4, OR7, NR5R6, NHSO 2 R10, a straight or branched C 1 -C 6 alkyl optionally substituted by a heterocyclyl, in its turn optionally substituted by a straight or branched C 1 -C 6 alkyl or an heterocyclylalkyl, or a heterocyclyl optionally substituted by a straight or branched C 1 -C 6 alkyl, in its turn optionally substituted by a heterocyclyl or a C 1 -C 6 alkoxycarbonyl, or a C 1 -C 6 dialkylamino: R4 is NR5R6, or a heterocyclyl, optionally further substituted by a straight or branched C 1 -C 6 alkyl, heterocyclylalkyl, heterocyclyl or a C 1 -C 6 dialkylamino; R5 and R6 are independently hydrogen, R8R9N—C 2 -C 6 alkyl, R8O—C 2 -C 6 alkyl, a straight or branched C 1 -C 6 alkyl optionally further substituted by C 1 -C 6 alkoxy, C 1 -C 6 dialkylamino, halogen, phenyl, hydroxyl or heterocyclyl in its turn optionally substituted by alkyl, C 3 -C 6 cycloalkyl optionally substituted by hydroxyl or trifluoro C 1 -C 6 alkyl, heterocyclyl optionally substituted by C 1 -C 6 alkyl in its turn optionally substituted by halogen or heterocyclyl, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 dialkylamino, heterocyclyl, or phenyl, or R5 and R6, taken together with the nitrogen atom to which they are bonded, may form a heterocyclyl group optionally substituted by a straight or branched C 1 -C 6 alkyl, in its turn optionally substituted by a heterocyclyl or a C 1 -C 6 alkoxycarbonyl, a C 1 -C 6 dialkylamino or a heterocyclyl; R7 is straight or branched C 1 -C 6 alkyl, optionally substituted by C 1 -C 6 dialkylamino or heterocyclyl in its turn substituted by C 1 -C 6 alkyl; R8 and R9 are independently an optionally further substituted straight or branched C 1 -C 6 alkyl; R10 is an optionally further substituted straight or branched C 1 -C 6 alkyl; R is phenyl or pyridyl optionally substituted halogen or straight or branched C 1 -C 6 alkyl; R1, R2 and R3 are hydrogen; or optical isomers, tautomers or pharmaceutically acceptable salt thereof.