Patent ID: 8217027

Claim:
A compound of Formula I a pharmaceutically acceptable salt, prodrug, metabolite or an isomer thereof wherein D is H, N(R 5 ) 2 or OR 6 ; X is CH; Y is CH 2 ; A is hydroxy, —CH 2 OH, —CH(OH)CH 3 , —C(O)—OCH 3 , —C(OH)(CH 3 ) 2 , —O(CH 2 ) t —COOH—, —C(O)—NR 6 , optionally substituted —(CH 2 ) n —P(═O)(OR 7 )(OR 7 ), optionally substituted —(CH 2 ) n —O—P(═O)(OR 7 )(OR 7 ), optionally substituted —(CH 2 ) n —P(═O)(OR 7 )(R 7 ), —CH═CH—P(═O)(OR 7 )(OR 7 ), C(O)—NHCH 3 , COOR 6 or —R 4 —COOH, wherein R 4 is straight or branched (C 1 -C 20 ) alkylene, straight or branched (C 1 -C 20 ) alkenylene, straight or branched (C 1 -C 20 ) alkynylene, (C 3 -C 20 )cycloalkyl, or optionally substituted azetidinyl; R 1 and R 2 are independently selected from the group consisting of hydrogen, CF 3 , halo, (C 1 -C 20 ) alkyl, (C 1 -C 20 ) alkoxy, (C 3 -C 20 ) cycloalkyl substituted alkyl, (C 3 -C 20 ) cycloalkyl substituted alkoxy, (C 2 -C 20 ) alkenyl, aryl substituted (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl, aryl substituted (C 2 -C 20 ) alkynyl, aryl, aryl substituted (C 1 -C 20 )alkyl, heteroaryl substituted (C 2 -C 20 )alkyl, aryl substituted alkoxy, heteroaryl substituted alkoxy, alkyl substituted aryl, arylalkyl, aryl substituted arylalkyl, arylalkyl substituted arylalkyl, CN and —O-indolizinyl; wherein such R 1 and R 2 groups may be optionally substituted with one or more substitutents independently selected from (C 1 -C 20 ) alkyl, CF 3 , halo, hydroxy, (C 1 -C 20 ) alkoxy, OCF 3 , and CN; wherein one or more of the carbon atoms in the R 1 or R 2 groups can be independently replaced with non-peroxide oxygen, sulfur or NR 8 ; wherein R 8 is hydrogen or (C 1 -C 20 ) alkyl group; wherein one of R 1 and R 2 is other than hydrogen; and wherein the alkyl, alkenyl, and alkynyl groups in R 1 and R 2 are optionally substituted with oxo or halo; each R 5 is independently H, optionally substituted (C 1 -C 3 )alkyl, or —C(O)—O—(C 1 -C 3 )alkyl-optionally substituted phenyl; each R 6 is optionally substituted (C 1 -C 2 )alkyl; each R 7 is independently H, optionally substituted (C 1 -C 2 )alkyl or optionally substituted phenyl; m is 1 or 2; n is 1, 2 or 3; t is 1, 2 or 3; and u is 1; provided that A and D are not both H at the same time and provided the compound is not wherein X is CH; Y is CH 2 .