Patent ID: 7271179

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W and X are each independently oxygen or sulfur; A is nitrogen, CH, C—CN, or C—(C 1-3 aliphatic); R 1 and R 2 are taken together to form an optionally substituted 3-7 membered saturated, partially unsaturated, or fully unsaturated ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Q is —C(O)—, —C(O)NR—, —C(O)C(O)—, —CO 2 —, —C(O)CO 2 —, —SO 2 —, or an optionally substituted C 1-6 alkylidene chain, wherein: one or two non-adjacent methylene units of Q are optionally and independently replaced by —O—, —S—, —NR—, —C(O)—, —CO 2 —, —C(O)NR—, —OC(O)NR—, —NRC(O)—, NRCO 2 —, —NRC(O)NR—, —S(O)—, —SO 2 —, —NRSO 2 —, —SO 2 NR—, or —NRSO 2 NR—; each R is independently hydrogen or an optionally substituted C 1-6 aliphatic group, wherein: two R bound to the same nitrogen atom are optionally taken together with the nitrogen to form an optionally substituted 3-7 membered saturated, partially unsaturated, or fully unsaturated ring having 0-2 heteroatoms, in addition to the nitrogen bound thereto, independently selected from nitrogen, oxygen, or sulfur; R 3 is Ar; and Ar is an optionally substituted ring selected from: (a) a 3-8 membered monocyclic or 8-10 membered bicyclic carbocyclic saturated, partially unsaturated, or aryl ring; or (b) a 5-6 membered monocyclic or 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, provided that said compound is not a compound selected from the group consisting of: 3-Chloro-benzo[b]thiophene-2-carboxylic acid [5-(7-chloro-quinolin-4-ylsulfanyl)-[1,3,4]thiadiazol-2-yl]-amide; N-[5-(7-Chloro-quinolin-4-ylsulfanyl)-[1,3,4]thiadiazol-2-yl]-2-phenoxy-nicotinamide; 5-Methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [5-(7-chloro-quinolin-4-ylsulfanyl)-[1,3,4]thiadiazol-2-yl]-amide; Cyclopropanecarboxylic acid [5-(7-chloro-quinolin-4-ylsulfanyl)-[1,3,4]thiadiazol-2-yl]-amide; Thiophene-2-carboxylic acid [5-(7-chloro-quinolin-4-ylsulfanyl)-[1,3,4]thiadiazol-2-yl]-amide; and 4-Hydroxy-2-oxo-2,3-dihydro-quinoline-3-carboxylic acid [5-(7-chloro-quinolin-4-ylsulfanyl)-[1,3,4]thiadiazol-2-yl]-amide.