Patent ID: 8461189

Claim:
A compound with the formula wherein Ar is phenyl, thienyl or pyridyl, optionally substituted with halo, methyl, methoxy, amino, hydroxyl or halomethyl; R 1 and R 2 are independently H, OH, halo, NH 2 , C 1 -C 4 alkyl, or C 1 -C 4 alkoxy; R 3 is independently H, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(═O)O—, C 1 -C 7 alkyl-C(═O)—, C 1 -C 7 alkynyl, halo, hydroxyalkoxy, C 1 -C 7 alkyl-NHSO 2 —, C 1 -C 7 alkyl-SO 2 NH—, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7 )alkylamino; R 4 is —NR 6 R 7 ; R 5 is independently H, OH, NH 2 , nitro, CN, amide, carboxyl, C 1 -C 2 alkoxy, C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkyloxy, C 1 -C 2 hydroxyalkyl, C 1 -C 2 alkenyl, C 1 -C 2 alkyl-C(═O)O—, C 1 -C 2 alkyl-C(═O)—, C 1 -C 2 alkynyl, halo, hydroxyalkoxy, C 1 -C 2 alkyl-NHSO 2 —, C 1 -C 2 alkyl-SO 2 NH—, C 1 -C 2 alkylsulfonyl, C 1 -C 2 alkylamino or di(C 1 -C 2 )alkylamino; R 6 is independently H, or C 1 -C 4 alkyl; R 7 is —(CR a 2 ) s C(O)(CR a 2 ) q R 13 , or —(CR a 2 ) s C(O)O(CR a 2 ) q R 12 ; R 12 is H, C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, heteroaryl, aryl or heterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, heterocyclic or aryl is optionally substituted with aryl, heteroaryl, halo, C 1 -C 4 alkyl, N(R 6 ) 2 , OH, C 1 -C 4 alkoxy or C 1 -C 4 haloalkyl; R 13 is H, C 2 -C 7 alkyl, C 3 -C 6 cycloalkyl, heteroaryl, or aryl, wherein the cycloalkyl, heteroaryl or aryl is optionally substituted with aryl, heteroaryl, halo, C 1 -C 4 alkyl, N(R 6 ) 2 , OH, C 1 -C 4 alkoxy or C 1 -C 4 haloalkyl; R a is independently H or C 1 -C 4 alkyl; Ring B is aryl or heteroaryl; p is 1, 2, 3 or 4; s and q are independently 0, 1, 2, 3, or 4; t is independently 1, 2, 3 or 4; L 1 is (CH 2 ) r , ethenyl or cyclopropyl, wherein r is 0, 1 or 2; X is OH or NH 2 ; or a stereoisomer or pharmaceutically acceptable salt thereof.