Patent ID: 7888484

Claim:
A humanized antibody or humanized antibody fragment that specifically binds IFN alpha receptor-1, comprising: a) a heavy chain variable region comprising the CDR1 amino acid sequence of (SEQ ID NO:1, the CDR2 amino acid sequence of SEQ ID NO:2), the CDR3 amino acid sequence of SEQ ID NO:3 or SEQ ID NO:3 consisting of a single amino acid substitution, and at least one variable region residue, or combination of residues, chosen from: an alanine at residue 24H; a methionine or an alanine at residue 29H; an isoleucine at residue 37H and a threonine at residue 40H; a proline at residue 40H; a lysine at residue 71H; a leucine at 78H, wherein the variable region residue is identified utilizing the Kabat numbering system; and (b) a light chain variable region comprising the CDR1 amino acid sequence of SEQ ID NO:4, the CDR2 amino acid sequence of SEQ ID NO:5, and the CDR3 amino acid sequence of SEQ ID NO:6, and at least one variable region residue chosen from: an alanine at residue 19L; a leucine at residue 37L; an alanine at residue 46L; an isoleucine at residue 58L; an aspartic acid at residue 70L; and a threonine at residue 83L, wherein the variable region residue is identified utilizing the Kabat numbering system.