Patent ID: 8148403

Claim:
A compound of formula 1 R 1 is H, halogen or OR 1.1 ; R 1.1 H or C 1-6 -alkyl R 2 is C 1-6 -alkyl, C 3-8 -cycloalkyl, C(R 2.1 ) 2 OR 2.1 or C(R 21 ) 2 N(R 2.1 ) 2 ; R 2.1 H, C 1-6 -alkyl or C 3-8 -cycloalkyl; R 3 is a group A optionally substituted by one or more R 3.1 ; A is C 3-8 -cycloalkyl, het or an annelated species of aryl or het; R 3.1 is C 1-6 -alkyl, COOR 3.1.2 , C 1-6 -alkyl-COOR 3.1.2 , C 1-6 -alkyl-COO—C 1-6 -alkyl-R 3.1.1 , CH 2 R 3.1.1 , NHCOR 3.1.3 , CON(R 3.1.3 ) 2 , C 1-6 -alkyl-CON(R 3.1.3 ) 2 , COO—C 1-6 -alkyl-R 3.1.1 , N(R 3.1.2 ) 2 , OR 3.1.2 , NO 2 , SO 2 N(R 3.1.2 ) 2 ; R 3.1.1 is NHC 1-6 -alkyl, N(C 1-6 -alkyl) 2 , an aromatic or nonaromatic 5 or 6 membered heterocycle containing one or two atoms selected from the group consisting of nitrogen, oxygen and sulfur, optionally substituted with a carbonyl group; R 3.1.2 is H or C 1-6 -alkyl; R 3.1.3 is H, C 1-6 -alkyl or C 3-8 -cycloalkyl, optionally substituted with halogen, COOR 3.1.3.1 , COR 3.1.3.1 , CONR 3.1.3.1 R 3.1.3.2 , NR 3.1.3.1 R 3.1.3.2 , NR 3.1.3.1 SO 2 R 3.1.3.2 , OR 3.1.3.1 , SR 3.1.3.1 , SOR 3.1.3.1 , SO 2 R 3.1.3.1 or SO 2 NR 3.1.3.1 R 3.1.3.2 ; R 3.1.3.1 is H, C 1-6 -alkyl or C 3-8 -cycloalkyl; R 3.1.3.2 is H, C 1-6 -alkyl or C 3-8 -cycloalkyl; D is CR 4 or N R 4 is F or H; and pharmaceutically acceptable salts thereof.