Patent ID: 8258149

Claim:
A compound of formula (I) wherein R 1 is selected from the group consisting of: hydrogen, alkyl, alkenyl, phenylalkyl, pyridinylalkyl, alkylpyrazolylalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkylaminocarbonylalkyl and oxetylaminocarbonylalkyl; R 4 is halogen or alkoxy; R 5 is halogen or alkoxy; R 6 is hydrogen or halogen; R 7 is hydrogen or halogen; wherein C a and C b are each carbon atoms and the bond between C a and C b is a single bond or a double bond; and wherein a) one of R 2 and R 3 is hydrogen and the other is selected from the group consisting of: phenyl, alkenyl and alkynyl; b) R 2 and R 3 are both at the same time alkyl, alkenyl or alkynyl; or c) R 2 and R 3 , together with the carbon atom to which they are attached, form cycloalkyl, cycloalkenyl, oxetyl or tetrahydropyranyl; or a pharmaceutically acceptable salt thereof; with the proviso that 9,10-dimethoxy-8,8-dimethyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 8,8-diethyl-9,10-dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 8,8-diethyl-9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 8-allyl-9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 8-allyl-9,10-dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 9,10-dimethoxy-8-pent-4-enyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; 9,10-dimethoxy-8-phenyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; and 9,10-dimethoxy-8,8-dimethyl-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline are excluded.