Patent ID: 8038645

Claim:
A computer-controlled device for time-controlled administration of an anesthetic, said device comprising: a) a module for inputting individual parameters of the patient and substance-specific input parameters of the anesthetic to be administered as well as a substance-dependent target profile, which shows a desired concentration/time course in the brain or a desired effect/time course administered as a function of time, connected to b) a physiology-based and/or pharmodynamic computer model module for a physiology-based pharmacokinetic and/or pharmacodynamic simulation of a dosage time profile which is variable over time taking into account the individual parameters of the patient and the substance-specific input parameters of the anesthetic to be administered, iterative numerical fit of the simulated dose profile until it agrees with the target profile or shows the maximum achievable agreement with it and output of an adapted dosage time profile, wherein the physiology-based and/or pharmodynamic computer model module is connected to c) a metered dose device controlled on the basis of the outputted adapted dosage time profile, and wherein the anesthetic is propofol.