Patent ID: 8884060

Claim:
A process for preparing a compound of Formula IV: wherein: A is optionally substituted aryl or optionally substituted heteroaryl; B is 3,5-di-methylphenyl; R 2 is tert-butyl; and R 8 , R 9 , R 10 , R 11 and R 12 are hydrogen; wherein the asymmetric carbon atom to which R 2 is attached is enantiomerically enriched in the R isomer comprising: a) reacting a compound of Formula V: with a compound of Formula VI: R 2 HC═N—NH—CO 2 R 7 Formula VI wherein: X and Y are independently O or NR wherein R is alkyl or aryl; C a and C b are independently an asymmetric carbon atom of the S configuration; R 14 and R 15 are independently alkyl or aryl; R 13 is halo, hydrogen, alkyl, alkoxy or OSO 2 CF 3 ; R 7 is alkyl, arylalkyl or aryl; R 2 is tert-butyl and R 8 , R 9 , R 10 , R 11 and R 12 are hydrogen; to form a compound of Formula VII: b) reducing the compound of Formula VII to form a compound of Formula VIII: c) reacting the compound of Formula VIII with a compound of Formula B-CO-LG wherein B is 3,5-di-methylphenyl and LG is a leaving group to form a compound of Formula IX: d) removing the R 7 CO 2 — group of the compound of Formula IX to form a compound of Formula X; and e) reacting the compound of Formula X with a compound of Formula A-CO-LG wherein A is optionally substituted aryl or optionally substituted heteroaryl and LG is a leaving group, to form a compound of Formula IV selected from the group consisting of: (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N′-benzoyl-N-(1-tert-butyl-butyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-methyl-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-fluoro-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(2-bromo-benzoyl)-N-(1-tert-butyl-butyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(3-methyl-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(4-methyl-benzoyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-chloro-pyridine-3-carbonyl)-hydrazide; (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(6-chloro-pyridine-3-carbonyl)-hydrazide; and (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(3-methoxy-2-methyl-benzoyl)-hydrazide.