Patent ID: 8435938

Claim:
A process for the purification of vancomycin comprising the following steps: a) conditioning the column having a stationary phase with the pH of the mobile phase between 3.9 and 4.2; b) applying crude vancomycin dissolved in the mobile phase onto the column; c) applying a displacing agent to displace vancomycin out of the column and collecting the fractions of the eluate; d) combining and concentrating the fractions of the eluate with a purity exceeding 97%; e) adjusting a pH of the vancomycin solution with an aqueous solution of ammonia or alkaline base to a pH between 8.5 and 9.0; f) suspending the separated vancomycin salt from step e) in water and adjusting the medium with hydrochloric acid to a pH of about 3.0 to about 3.5; g) precipitation of vancomycin hydrochloride from the solution with an organic solvent; h) isolation of pure vancomycin hydrochloride.