Patent ID: 7132535

Claim:
A process for preparing a hexahydropyridazine-3-carboxylic acid derivative of the formula wherein R is selected from the group consisting of saturated or unsaturated, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl substituted or unsubstituted aryl comprising reacting a compound of the formula wherein R 2 is substituted or unsubstituted alkyl and R 3 a nucleofugal organic group, with a compound of the formula whereas R has the above meaning, in the presence of a base with a pK a greater than or equal to 8.5, in an organic ketone solvent to a tetrahydro- 1,2,3-pyridazine-tricarboxylate intermediate compound of the formula wherein R and R 2 have the above meanings, which is not isolated and which is treated with a basic aqueous medium, to obtain the hexahydropyridazine-3-carboxylic acid derivative of formula (I).