Patent ID: 8731655

Claim:
A method of performing a phototherapy procedure, the method comprising: (i) administering to a patient in need thereof, a therapeutically effective amount of a phototherapeutic composition to a target tissue, wherein, the phototherapeutic composition comprises a compound of formula (FX1) or (FX2); and (ii) exposing the administered phototherapeutic composition to electromagnetic radiation having wavelengths selected over the range of 350 nm and 1300 nm sufficient to result in injury or death to cells at the target tissue wherein: each of L 1 , L 2 , L 3 and L 4 , if present, is independently C 1 -C 10 alkylene, C 3 -C 10 cycloalkylene, C 2 -C 10 alkenylene, C 3 -C 10 cycloalkenylene, C 2 -C 10 alkynylene, ethenylene, ethynylene, phenylene, 1-aza-2,5-dioxocyclopentylene, —(CH 2 CH 2 O) b —, —(CHOH) a —, or 1,4-diazacyclohexylene; each of W 1 , W 2 , W 3 and W 4 is independently a single bond, a double bond, —(CH 2 ) c —, —(HCCH) c —, —O—, —S—, —SO—, —SO 2 —, —SO 3 —, —OSO 2 —, —NR 5 —, —CO—, —COO—, —OCO—, —OCOO—, —CONR 6 —, —NR 7 CO—, —OCONR 8 —, —NR 9 COO—, —NR 10 CONR 11 —, or —NR 12 CSNR 13 —; each of R 1 , R 2 , R 3 and R 4 is independently hydrogen, C 1 -C 20 alkyl, C 3 -C 20 cycloalkyl, C 5 -C 30 aryl, C 5 -C 30 heteroaryl, C 1 -C 20 acyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 5 -C 20 alkylaryl, C 1 -C 6 alkoxycarbonyl, halo, halomethyl, dihalomethyl, trihalomethyl, —CN, —CO 2 R 14 , —CONR 15 R 16 , —COR 17 , —NO 2 , —SOR 18 , —OSR 19 , —SO 2 R 20 , —SO 2 OR 21 , —SO 2 NR 22 R 23 , —PO 3 R 24 R 25 , —OR 26 , —SR 27 , —NR 28 R 29 , —NR 30 COR 31 , —(CHOH) a R 32 , —(CH 2 CH 2 O) b R 33 , —CH(R 34 )CO 2 H, —CH(R 35 )NH 2 , or wherein at least one of: R 1 , R 2 , W 1 , W 2 , and L 1 and L 2 , if present; and R 3 , R 4 , W 3 , W 4 , and L 3 and L 4 , if present; together with the atoms to which they are attached combine to form one or more alicyclic 4, 5, 6, 7, 8 or 9 membered rings; wherein at least one of R 1 , R 2 , R 3 and R 4 is C 5 -C 30 aryl or C 5 -C 30 heteroaryl, or wherein at least one of: R 1 , R 2 , W 1 , W 2 , and L 1 and L 2 , if present, and R 3 , R 4 , W 3 , W 4 , and L 3 and L 4 , if present; together with the atoms to which they are attached combine to form a C 5 -C 30 aryl or C 5 -C 30 heteroaryl; wherein R 1 -R 4 do not include an azide group; each of a and b is independently an integer selected from the range of 1 to 100; each c is independently an integer selected from the range of 1 to 10; each of e, f, g and j is independently 0 or 1; each of R 5 -R 31 is independently hydrogen, C 1 -C 20 alkyl, C 5 -C 30 aryl or C 5 -C 30 heteroaryl; each of R 32 and R 33 is independently hydrogen or C 1 -C 10 alkyl; each of R 34 and R 35 is independently a side chain residue of a natural α-amino acid.