Patent ID: 7214242

Claim:
A method for producing a bioremodelable prosthetic tube construct comprising at least two layers of processed tissue matrix wherein the method comprises: (a) flagging the processed tissue matrix around a sleeve-covered mandrel by hydrating one edge of the processed tissue matrix and contacting the sleeve-covered mandrel by hydrating one edge of the processed tissue matrix and contacting the sleeve-covered mandrel to the hydrated edge of the processed tissue matrix; (b) drying the processed tissue matrix to the sleeve-covered mandrel; (c) rehydrating the processed tissue matrix with a hydrating agent to form hydrated tissue matrix; (d) rotating the mandrel at least twice to wrap the hydrated processed tissue matrix to form at least two wrapped hydrated layers of processed tissue matrix; (e) dehydrating the layers of the processed tissue matrix; and (f) contacting the layers of the processed tissue matrix with a crosslink agent to crosslink the collagen.