Patent ID: 7696188

Claim:
A substituted tetracycline compound of the formula(I) or a pharmaceutically acceptable salt thereof: wherein: R 4 and R 4′ are each methyl; R 5 is hydrogen or hydroxyl; R 6 and R 6′ are each independently hydrogen, methyl, or hydroxyl; R 7 is substituted or unsubstituted phenyl, wherein said substituted phenyl is phenyl substituted with at least one substituent selected from the group consisting of halogen, hydroxyl, alkoxy, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkylaminocarbonyl, aralkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkenylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylthiocarbonyl, phosphate, phosphonato, phosphinato, cyano, amino, alkylamino, dialkylamino, arylamino, diarylamino alkylarylamino, acylamino, alkylcarbonylamino, arylcarbonylamino, carbamoyl, ureido, amidino, imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfate, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, cyano, azido, heterocyclyl, alkylaryl, an aromatic moiety and a heteroaromatic moiety; R 8 is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl; and R 9 is hydrogen, amino, acetamide, or lower alkynyl.