Patent ID: 7030141

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof wherein: A is aryl or substituted aryl or monocyclic heteroaryl or substituted monocyclic heteroaryl; B is wherein “ ” indicates the point of attachment; Q is NH or is absent; and wherein R 1′ is OH, —O—(C 1 -C 6 ), or NR 3′ R 4′ , wherein R 3′ and R 4′ are independently H, (C 1 -C 6 )alkyl, or are joined together to form a optionally substituted saturated or unsaturated 5 to 7 membered ring; C is phenyl or heteroaryl, wherein phenyl or heteroaryl is optionally substituted with one or more substituents selected from aryl, heteroaryl, halogen, hydroxy, —CO 2 R 2 , —COR 2 , —CONR 2 R 2′ , alkoxy, alkyl, —CN, haloalkyl, amino, alkylamino, amidino, amido, or sulfonamido; G is H, halo, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, —CH 2 O—(C 1 -C 6 )alkyl, —CH 2 —CO 2 (C 1 -C 6 )alkyl, —CH 2 —CONH 2 , or —CH 2 —CONH(C 1 -C 6 )alkyl; W 1 is —CH 2 —CH 2 —CH 2 —, —CH 2 —CH 2 —CR 5 R 6 —, —CH 2 —CR 5 R 6 —CH 2 —, —CH 2 —CH 2 —CR 7 —R 8 —, —CH 2 —CR 7 R 8 —CH 2 —, —CH 2 —CR 9 —CH 2 —, or —CH 2 —CH 2 —CR 9 —, wherein W 1 connects the nitrogen atom at position 1 to the carbon atom at position 2 to form a five membered ring; R 1 is (C 1 -C 6 )alkoxy, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )heterocycloalkyl, (C 4 -C 7 )cycloalkenyl, (C 4 -C 7 )heterocycloalkenyl, aryl, monocyclic heteroaryl, or —NR 3 R 4 ; R 2 and R 2′ are each independently H or (C 1 -C 6 )alkyl; and R 3 and R 4 are each independently H, (C 1 -C 6 )alkyl, aralkyl, aryl, monocyclic heteroaryl, alkaxycarbonyl, aralkoxycarbonyl, —SO 2 alkyl, or joined together to form a saturated or unsaturated 3 to 7 membered ring and; R 5 is —OH, alkyl, halo(C 1 -C 6 )alkyl, —NR 3 R 4 , —OR 2 , halo, —CN, —CH 2 OR 2 , —CH 2 —NR 3 R 4 , aryl, monocyclic heteroaryl, alkylaryl, —CONR 3 R 4 , —COR 2 , halo(C 1 -C 6 )alkyl, or —CO 2 R 2 and; R 6 is H, alkyl, aralkyl, aryl, or monocyclic heteroaryl; and R 7 and R 8 are each independently halo; and R 9 is ═O or ═NOR 2 .