Patent ID: 8063221

Claim:
A compound of Formula Ia: or a pharmaceutically acceptable salt thereof, wherein R 1 is cycloalkyl, aryl or aralkyl; R 2 is hydrogen or lower alkyl; R 3 is H or —COOH; R 5 is amino, optionally substituted with one or two lower alkyl groups; R 6 is halo; R 8 is halo or alkoxy; R a is selected from hydrogen and lower alkyl; R b is —(CH 2 ) n (NR c ) m R or —(CH 2 ) n OR d ; R c is hydrogen or lower alkyl; R is aryl, heteroaryl, —C(O)OR d or —C(O)R d ; R d is alkyl, aryl, heterocyclyl, heteroaryl or cycloalkyl; n is 0 to 6; and m is 0 or 1, where R and R d are optionally substituted with 1, 2, 3 or 4 substituents, each independently selected from Q 1 , where Q 1 is halo, hydroxy, cyano, thiocyano, selenocyano, azide, amino, nitro, alkyl, alkenyl, alkynyl, aryl or cycloalkyl.