Patent ID: 7981652

Claim:
An isolated mutant monoogygenase having the amino acid sequence SEQ ID NO: 2, except for a modification consisting of a mutation in each of amino acid sequence positions 87 and 188 and, optionally, at least one mutation in one of amino acid sequence positions 26, 47, 72, 74 and 354, wherein: Phe 87 is replaced by Val, Ala or Leu; Leu 188 is replaced by Asn, Gln, Arg, Lys, Ala, Gly, Ser or Trp; Ala 74 is replaced by Val or Gly; Arg 47 is replaced by His, Tyr or Phe; Val 26 is replaced by Ser or Thr; Ser 72 is replaced by Ala, Leu, Ile or Gly; or, Met 354 is replaced by Ser or Thr.