Patent ID: 7807793

Claim:
A humanized antibody comprising a heavy chain and a light chain, said antibody characterized by a dissociation constant equal to or less than about 2×10 −10 M for human IL4, wherein amino acid sequences of the complementarity determining regions for the heavy chain are, in order: (a) ThrSerGlyMetGlyValSer, SEQ ID NO:22 (b) HisIleTyrTrpAspAspAspLysArgTyrAsn SEQ ID NO:24 ProSerLeuLysSer, and (c) ArgGluThrValPheTyrTrpPheAspVal; SEQ ID NO:26 and wherein amino acid sequences of the complementarity determining regions for the light chain are, in order: (a) LysAlaSerGlnSerValAspTyrAspGlyAsp SEQ ID NO:16 SerTyrMetAsn, (b) AlaAlaSerAsnLeuGluSer, SEQ ID NO:18 and (c) any one of GlnGlnSerAsnGluAspPro SEQ ID NO:20 ProThr or GlnGlnSerAsnGluAsp ProProArg. SEQ ID NO:28