Patent ID: 7354927

Claim:
A compound of formula I having structure: wherein: A and Aâ€² are each independently OH, H or OR; each R is independently selected from the group consisting of C 1 -C 6 alkyl, alkenyl, benzyl, acyl, aroyl, â€”C(â•O)â€”ORâ€², sulfonyl and phosphorl, wherein each Râ€² is independently selected from C 1 -C 6 alkyl, alkenyl, C 2 -C 7 alkynyl, or C 3 -C 10 cycloalkyl, each of which which are optionally substituted by 1 to 3 substituents selected from C 1 -C 6 alkyl or halogen; R 1 and R 2 are independently selected from the group consisting of H, halogen, C 1 -C 6 alkyl, C 1 -C 6 perhaloalkyl, CF 3 , C 2 -C 7 alkenyl and C 1 -C 6 alkoxy; R 3 , R 4 , and R 5 are each independently selected from the group consisting of H, halogen, CF 3 , C 1 -C 6 perhaloalkyl, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 7 cycloalkyl, CN, â€”CHO, acyl, aryl and heteroary; R 6 is selected from the group consisting of H, CF 3 , C 1 -C 6 perhaloalkyl, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 7 cycloalkyl, CN, â€”CHO, acyl, acyl and heteroaryl; wherein the alkyl or alkenyl moieties of R 3 , R 4 , R 5 and R 6 can each be optionally substituted with up to three substituents independently selected from halogen, OH, CN, trifluoroalkyl, trifluoroalkoxy, NO 2 or phenyl, wherein said phenyl is optionally substituted with up to three independently selected R 10 groups; wherein the alkynyl moiety of R 3 , R 4 , R 5 and R 6 can each be optionally substituted with up to three substituents selected from halogen, â€”CN, â€”CHO, acyl, trifluoroalkyl, trialkylsilyl or phenyl, wherein said phenyl is optionally substituted with up to three independently selected R 10 groups; wherein the aryl or heteroaryl moiety of R 3 , R 4 , R 5 and R 6 can each be optionally substituted with up to three substituents selected from halogen, â€”CN, alkyl, alkoxy, perfluoroalkyl or perfluoroalkoxy; each R 10 is independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, â€”OH, C 1 -C 6 alkoxy, â€”CN, â€”CHO, â€”NO 2 , amino, C 1 -C 6 alkylamino, di-(C 1 -C 6 ) alkylamino, thiol, and C 1 -C 6 alkylthio; and n is 0, 1, 2, or 3; provided that: at least one of A and Aâ€² is not H; if n is 0, then R 3 is not halogen; and at least one of R 3 , R 4 and R 5 is halogen, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 7 cycloalkyl, â€”CN, â€”CHO, acyl, aryl or heteroaryl; or an N-oxide thereof or a pharmaceutically acceptable salt thereof.