Patent ID: 8604032

Claim:
A compound of formula (Ib): or a pharmaceutically acceptable salt thereof, wherein B is hydrogen, or a moiety of Formula II: wherein W c is 6-membered aryl or cycloalkyl; q is an integer of 0, 1, 2, 3, or 4; X is absent or —(CH(R 9 )) z —, and z is an integer of 1, 2, 3, or 4; Y is absent, —O—, —S—, —S(═O)—, —C(═O)—, —C(═O)(CHR 9 ) z —, —N(R 9 )—, —N(R 9 )—C(═O)NH—, or —N(R 9 )C(R 9 ) 2 —, and z is an integer of 1, 2, 3, or 4; R 1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro; each R 2 is independently alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, or carbonate; R 3 is a 5-membered heteroaryl, a 5-membered nonaromatic heterocyclyl, a 6-membered heteroaryl, or a 6-membered nonaromatic heterocyclyl, each of which comprises at least one ring nitrogen, and each of which can be substituted with 0, 1, 2, or 3 R 13 ; R 5 , R 6 , R 7 , and R 8 are independently hydrogen, halo, cyano, alkyl, or amino; each R 9 is independently hydrogen, alkyl, or heterocycloalkyl; W d is R 11 is hydrogen, alkyl, halo, amino, amido, hydroxy, alkoxy, phosphate, urea, or carbonate; R 12 is hydrogen, alkyl, haloalkyl, alkynyl, alkenyl, halo, —C(O)NH 2 , NH 2 , cyano, aryl, heteroaryl, nonaromatic heterocyclyl, or cycloalkyl; R a is methyl; R a′ is hydrogen, alkyl, —NH 2 , cyano, or halogen; and each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, or halogen.