Patent ID: 8022092

Claim:
A compound of the formula I: wherein; R 1 is an optionally substituted, branched C 2 -C 6 alkyl, wherein the alkyl branches at position 1, especially wherein R 1 is —CH(CH 3 ) 2 , —C(CH 3 ) 3 or —CH(CH 3 )(CH 2 CH 3 ) R 2 is carbocyclyl or heterocyclyl; R 3 is H or C 1 -C 4 alkyl; R 4 is H or C 1 -C 4 alkyl; each R 5 and R 5′ is independently H, C 1 -C 4 alkyl or halo; or R 4 and an adjacent R 5′ together define a double bond; each R 6 and R 6′ is independently H, C 1 -C 4 alkyl or halo; or R 5 and an adjacent R 6 together define a double bond; or R 5 , R 5′ and an adjacent R 6 and R 6′ together define a triple bond; n is 1-3, m is 0-3; D is absent, or D is an ether, thioether, amine, amide, carbamate, urea or sulphonamide linkage; whereby the group (CR 5 R 5′ ) n -D-(CR 6 R 6′ ) m has at least 2 chain atoms; X and Y are independently O or S; and wherein each C 1 -C 4 alkyl is optionally substituted with 1 to 3 halo or an hydroxyl; each C 1 -C 6 alkyl, carbocyclyl or heterocyclyl (including those in any C 0 -C 3 alkanediylcarbocyclyl or C 0 -C 3 alkanediylheterocyclyl groups) is independently optionally substituted with 1 to 3 substituents selected from halo, oxo, cyano, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 Alkdiylcarbocyclyl, C 0 -C 3 Alkdiylheterocyclyl, Z—NRaRb, Z—O—Rb, Z—S—Rb, Z—C(═NOH)Rb, Z—C(═O)Rb, Z—(C═O)NRaRb, Z—NRaC(═O)Rb, Z—NRaSO p Rb, Z—S(═O) p Rb, Z—S(═O) p NRaRb, Z—C(═O)ORb, Z—OC(═O)Rb Z—NRaC(═O)ORb or Z—OC(═O)NRaRb; wherein; each C 0 -C 3 Alkdiyl is independently a bond, a C 1 -C 3 straight or branched, saturated carbon chain or a C 2 -C 3 straight or branched unsaturated carbon chain; the carbocyclyl or heterocyclyl moiety of any C 0 -C 3 Alkdiylcarbocyclyl, C 0 -C 3 Alkdiylheterocyclyl is optionally substituted 1 to 3 times with substituents selected from halo, oxo, cyano, azido, nitro, C 1 -C 4 alkyl, Z—NRaRc, Z—O—Rc, Z—S—Rc, Z—C(═O)Rc, Z—(C═O)NRaRc, Z—NRaC(═O)Rc, Z—NRaSO p Rc, Z—S(═O) p Rc, Z—S(═O) p NRaRc, Z—C(═O)ORc, Z—OC(═O)Rc, Z—NRaC(═O)ORc, or Z—OC(═O)NRaRc; each Z is independently a bond or C 1 -C 3 alkanediyl; each Ra is independently H or C 1 -C 4 alkyl; each Rb is independently H or C 1 -C 6 alkyl, C 0 -C 3 Alkdiylcarbocyclyl, C 0 -C 3 Alkdiylheterocyclyl; or Ra and Rb together with an adjacent N atom define pyrrolidine, piperidine, morpholine, piperazine or N-methyl piperazine; Rc is H or C 1 -C 4 alkyl; or Rc and Ra together with an adjacent N atom define pyrrolidine, piperidine, morpholine, piperazine or N-methyl piperazine each p is independently 1 or 2; or pharmaceutically acceptable salts thereof.