Patent ID: 8030328

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof wherein A is —H, optionally substituted aryl, optionally substituted heteroaryl or the group —C(X)D(R 3 )Z, wherein D is a carbon atom (when part of a substituted aryl or substituted heteroaryl), CH, N or O, with the proviso that if D is oxygen, then Z is not present; Z is —H, —NO 2 , haloalkyl or the group —N(YR 1 )R 2 wherein Y is a covalent bond, —C(O)— or —SO 2 —, R 1 is R 1′ , N(R 1′ ) 2 , or —OR 1′ wherein each R 1′ is independently hydrogen, an optionally substituted straight or branched C 1 -C 6 alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclic or an optionally substituted heteroaryl, wherein optional substitutions are halide, C 1 -C 6 alkyl, —OC 1 -C 6 alkyl and R 2 is hydrogen or R 1′ ; X is selected from the group consisting of oxygen, sulfur, CHR 4 and NR 4 , wherein R 4 is —H, alkyl or substituted alkyl; R 3 is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic; or D, R 3 and Z together form a heterocyclic or a substituted heterocyclic group, wherein said group contains 1, 2, or 3 heteroatoms selected from O, N, and S; or X, D and R 3 together with the carbon atom carrying D and X form an optionally substituted carbocyclic or optionally substituted heterocyclic group, wherein said heterocyclic group contains 1, 2, or 3 heteroatoms selected from O, N, and S; R 3 and R 4 together with the nitrogen atom bound to R 4 and the carbon atom bound to R 3 form a heterocyclic or a substituted heterocyclic group, wherein said group contains 1, 2, or 3 heteroatoms selected from O, N, and S; R 5 is selected from the group consisting of amino, substituted amino, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, aryloxy and substituted aryloxy, and —OH; n is 0 or an integer from 1 to 4; Q is a group of the formula V1 or V2 wherein the pyrido portion of V1 and the benzo portion of V2 are each optionally substituted; and R 6 is —H, alkyl, substituted alkyl, or —CH 2 C(O)R 7 wherein R 7 is —OH, —OR 8 , or —NHR 8 wherein R 8 is alkyl, substituted alkyl, aryl or substituted aryl; R 21 , R 22 , R 23 , and R 24 are independently selected from the group consisting of hydrogen, —C 1 -C 3 alkyl, —OC 1 -C 3 alkyl and halogen.