Patent ID: 8057814

Claim:
An intravascular stent comprising a metal body having a coating comprising polymer and a restenosis inhibiting agent in which the restenosis inhibiting agent is a sparingly water soluble matrix metallo-proteinase inhibitor (MMPI) and the polymer in the coating is a cross-linked amphiphilic polymer formed from a crosslinkable polymer of formula IX wherein l is 1 to 75, m is 0 to 99, n is 0 to 33 and m+n is 25 to 99, Y 3 , Y 4 , and Y 5 are the groups derived from Y, Y 1 , and Y 2 respectively, of the radical initiated addition polymerisation of the ethylenic group in Y, Y 1 , and Y 2 , wherein Y, Y 1 , and Y 2 are independently selected from the group consisting of CH 2 â•C(R)CH 2 Oâ€”, CH 2 â•C(R)CH 2 OC(O)â€”, CH 2 â•C(R)OC(O)â€”, CH 2 â•C(R)Oâ€”, CH 2 â•C(R)CH 2 OC(O)N(R 1 )â€”, R 2 OOCCRâ•CRC(O)Oâ€”, RCHâ•CHC(O)Oâ€”, RCHâ•C(COOR 2 )CH 2 C(O)Oâ€”, wherein: R is hydrogen or a C 1 -C 4 alkyl group; R 1 is hydrogen or a C 1 -C 4 alkyl group or R 1 is â€”Bâ€”X; R 2 is hydrogen or a C 1-4 alkyl group; A is â€”Oâ€” or â€”NR 1 â€”; K is a group selected from the group consisting of â€”(CH 2 ) p OC(O)â€”, â€”(CH 2 ) p C(O)Oâ€”, â€”(CH 2 ) p OC(O)Oâ€”, â€”(CH 2 ) p NR 3 â€”, â€”(CH 2 ) p NR 3 C(O)â€”, â€”(CH 2 ) p C(O)NR 3 â€”, â€”(CH 2 ) p NR 3 C(O)Oâ€”, â€”(CH 2 ) p OC(O)NR 3 â€”, â€”(CH 2 ) p NR 3 C(O)NR 3 â€” (in which the groups R 3 are the same or different), â€”(CH 2 ) p Oâ€”, â€”(CH 2 ) p SO 3 â€”, or, optionally in combination with B, a valence bond; p is from 1 to 12; R 3 is hydrogen or a C 1 -C 4 , alkyl group; B is a straight or branched alkylene (alkanediyl), alkyleneoxaalkylene, alkylene oligo-oxaalkylene chain optionally containing one or more fluorine atoms up to and including perfluorinated chains, or a valence bond; B 2 is a straight or branched alkylene, oxaalkylene, oligo-oxaalkylene chain optionally containing one or more fluorine atoms up to and including perfluorinated chains, or a valence bond; X is a zwitterionic group; R 13 is a hydrophobic group; and R 20 is a cross-linkable group.