Patent ID: 7977342

Claim:
A method comprising: administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition, which inhibits HCV replication, comprising a compound of a formula: or a pharmaceutically acceptable salt thereof; wherein the fused ring bridging positions 5 and 6 of the pyrimidine ring together with the pyrimidine ring forms a group selected from wherein any of these groups may be optionally substituted with one or two alkyl(1-6C); R 3 is hydrogen, alkyl(1-6C), or —CONR 2 ; each R 4a R 4b are, independently, hydrogen or halo; and, wherein each R is independently hydrogen, hydroxyl, amino, mono- or dialkyl(1-6C)amino, cycloalkyl(3-7C), Het, or alkyl(1-6C) optionally substituted with one or two substituents selected from hydroxyl, cycloalkyl(3-7C), amino, mono- or dialkyl(1-6C)amino, and Het, wherein said method inhibits HCV replication.