Patent ID: 7807379

Claim:
A method for determining whether an individual is likely to have colorectal cancer, the method comprising: a. determining a total concentration of TIMP-1 in a plasma sample of said individual and determining a concentration of at least one additional marker different from any form of TIMP-1 in a body fluid sample of said individual, b. combining the total concentration of TIMP-1 in the plasma sample of said individual and the concentration of said at least one additional marker different from any form of TIMP-1 in the body fluid sample of said individual to result in a combined parameter of the individual, c. combining a total plasma concentration of TIMP-1 of a non-colorectal cancer population with a body fluid concentration of the at least one additional marker different from any form of TIMP-1 of a non-colorectal cancer population, the resulting combination being referred to herein as a non-colorectal cancer benchmark combined parameter, d. indicating the individual as likely to have colorectal cancer if the combined parameter of the individual is at or above said non-colorectal cancer benchmark combined parameter and indicating the individual as unlikely of having colorectal cancer if the combined parameter is below said non-colorectal cancer benchmark combined parameter and wherein the combining in the sub-sections b. and c. is performed by logistic regression analysis.