Patent ID: 8785448

Claim:
A method for treating cell proliferative disorders caused by and/or associated with an altered cell cycle dependent kinase activity, the cell proliferative disorder selected from the group consisting of ovarian cancer, breast cancer, colon cancer, non-small cell lung cancer, small cell lung cancer and mesothelioma, the method comprising administering to a mammal in need thereof an effective amount of a compound represented by formula (Ib) wherein R is a group —COR a , —CONHR a or —CONR a R b wherein R a and R b are, each independently, hydrogen or an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl or; together with the nitrogen atom to which they are bonded, R a and R b may form an optionally substituted 5 or 6 membered heterocycle optionally containing one additional heteroatom or heteroatomic group selected among N, NH, O or S; R 1 is selected from the group consisting of: a) straight or branched C 3 -C 4 alkyl; b) cycloalkyl, cycloalkyl-alkyl or alkyl-cycloalkyl wherein the cycloalkyl moiety comprises any C 3 -C 6 cycloalkyl group and wherein the alkyl moiety comprises any straight or branched C 1 -C 4 alkyl group: c) 3-methylthienyl-2-yl; 2-thienyl; phenyl; 2,6-difluorophenyl; 4-(aminosulfonyl)phenyl; 4-(dimethylaminomethyl)phenyl; 4-(4-methylpiperazinyl)methyl-phenyl; d) a group of formula (IIa) or (IIb): wherein, in formula (IIa), the cycle represents a 5 to 7 membered heterocyclic ring wherein X, directly linked to the rest of the molecule, represents a carbon or nitrogen atom; Y is a carbon, nitrogen, oxygen or sulfur atom or it is an NH group, provided that at least one of X and Y is other than a carbon atom; R c is, independently from each other and in any one of the free positions of the heterocyclic ring of formula (IIa), a halogen atom or hydroxy group or it is an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, amino, aminocarbonyl, carboxy, xox (═O), alkoxycarbonyl, alkylcarbonyl or arylcarbonyl; and n is 0 or an integer from 1 to 4; e) a group of formula (IIc) or (IId): wherein R d , R′ d and R e represent, the same or different and independently from each other, a hydrogen atom or a straight or branched C 1 -C 6 alkyl optionally substituted by one or more groups selected from hydroxy (—OH), aminocarbonyl (—CONH 2 ) or methylaminocarbonyl (—CONHCH 3 ); or a pharmaceutically acceptable salt thereof.