Patent ID: 7910602

Claim:
A compound of the formula (I) wherein R 1 is H or (C 1 -C 6 )alkyl, wherein the (C 1 -C 6 )alkyl group is unsubstituted or substituted by one or more OH, halogen or NH 2 groups; R 2 is phenyl, (C 3 -C 10 )cycloalkyl group or (C 4 -C 10 )heterocyclyl group, each of which are unsubstituted or substituted independently by 1, 2 or 3 residues selected from 1) (C 1 -C 6 )alkyl, 2) (C 2 -C 6 )alkenyl, 3) (C 2 -C 6 )alkynyl, 4) (C 1 -C 6 )alkylene-COOH, 5) (C 1 -C 6 )alkylene-C(O)O—(C 1 -C 6 )alkyl, 6) (C 1 -C 6 )alkylene-C(O)NH 2 , 7) (C 1 -C 6 )alkylene-C(O)NH—(C 1 -C 6 )alkyl, 8) (C 1 -C 6 )alkylene-O—(C 1 -C 6 )alkyl, 9) (C 1 -C 6 )alkylene-OH, 10) (C 1 -C 6 )alkylene-NH 2 , 11) (C 1 -C 6 )alkylene-NH—(C 1 -C 6 )alkyl, 12) (C 1 -C 6 )alkylene-N[(C 1 -C 6 )alkyl] 2 , 13) CN, 14) COOH, 15) C(O)O—(C 1 -C 6 )alkyl, 16) C(O)NH 2 , 17) C(O)NH—(C 1 -C 6 )alkyl, 18) C(O)N[(C 1 -C 6 )alkyl] 2 , 19) C(O)—(C 1 -C 6 )alkyl, 20) halogen, 21) NH 2 , 22) NH(C 1 -C 6 )alkyl, 23) N[(C 1 -C 6 )alkyl] 2 , 24) NH—C(O)—(C 1 -C 6 )alkyl, 25) OH, 26) O—(C 1 -C 6 )alkyl, 27) O—(C 2 -C 6 )alkenyl, 28) O—(C 2 -C 6 )alkynyl, 29) O—(C 1 -C 6 )alkylene-C(O)OH, 30) O—(C 1 -C 6 )alkylene-C(O)O—(C 1 -C 6 )alkyl, 31) O—(C 1 -C 6 )alkylene-C(O)NH 2 , 32) O—(C 1 -C 6 )alkylene-C(O)NH—(C 1 -C 6 )alkyl, 33) O—(C 1 -C 6 )alkylene-OH, 34) O—(C 1 -C 6 )alkylene-O—(C 1 -C 6 )alkyl, 35) O—(C 1 -C 6 )alkylene-NH 2 , 36) O—(C 1 -C 6 )alkylene-NH—(C 1 -C 6 )alkyl, 37) O—C(O)—(C 1 -C 6 )alkyl, 38) S—(C 1 -C 6 )alkyl, 39) S(O) 2 —(C 1 -C 4 )alkyl, 40) (C 6 -C 10 )aryl, 41) (C 4 -C 10 )heterocyclyl, 42) (C 1 -C 6 )alkylene-(C 6 -C 10 )aryl, 43) (C 1 -C 6 )alkylene-(C 4 -C 10 )heterocyclyl, 44) (C 1 -C 6 )alkylene-O—(C 6 -C 10 )aryl, 45) (C 1 -C 6 )alkylene-O—(C 4 -C 10 )heterocyclyl, 46) O—(C 6 -C 10 )aryl, 47) O—(C 4 -C 10 )heterocyclyl, 48) O—(C 1 -C 6 )alkylene-(C 6 -C 10 )aryl, and 49) O—(C 1 -C 6 )alkylene-(C 4 -C 10 )heterocyclyl, wherein the (C 6 -C 10 )aryl and (C 4 -C 10 )heterocyclyl in residues 40) to 49) are each unsubstituted or substituted independently by 1, 2 or 3 residues selected from OH, halogen, NH 2 , O—(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, S(O) 2 —(C 1 -C 4 )alkyl or (C 3 -C 10 )cycloalkyl; and/or is vicinally substituted by a residue of the formula —O—(CH 2 ) n —O—, wherein n is 1, 2 or 3 and wherein one or more hydrogen atoms may be replaced by halogen atoms; and R 3 is H, (C 1 -C 6 )alkyl or O—(C 1 -C 6 )alkyl, wherein the (C 1 -C 6 )alkyl is unsubstituted or substituted by OH, halogen, NH 2 , NH(C 1 -C 6 )alkyl or N[(C 1 -C 6 )alkyl] 2 , or (C 3 -C 10 )cycloalkyl, which is unsubstituted or substituted by one or more fluoro atoms; or a physiologically acceptable salt thereof.