Patent ID: 7655672

Claim:
A pharmaceutical cream for topical application to a dermal or mucosal surface for topical delivery of 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (imiquimod), said pharmaceutical cream comprising: a therapeutically effective amount of imiquimod; and a pharmaceutically acceptable vehicle including an oleic acid component, wherein the oleic acid component at or prior to formulation of said pharmaceutical cream contains at least about 80% oleic acid by weight as a fatty acid, and wherein the oleic acid component at or prior to formulation of said pharmaceutical cream has a peroxide value of less than about 5 milliequivalents of oxygen per kilogram and contains less than about 1% by weight polar impurities, and wherein said pharmaceutical cream contains imiquimod-related impurities in an amount of no more than about 0.03% wt./wt. after storage of said pharmaceutical cream at ambient conditions for about 15 days, when absorbance of said pharmaceutical cream is analyzed at about 308 nm using a UV detector.