Patent ID: 7799805

Claim:
A compound of formula (I): wherein W is a six-membered, non benzofused aromatic ring containing one nitrogen atom, wherein said ring is substituted by V in para position; V represents a bond; —(CH 2 ) r —; -A-(CH 2 ) s —; —CH 2 -A-(CH 2 ) t —; —(CH 2 ) s -A-; —(CH 2 ) 2 -A-(CH 2 ) u —; -A-(CH 2 ) v —B—; —CH 2 —CH 2 -CH 2 -A-CH 2 —; -A-CH 2 —CH 2 —B—CH 2 —; —CH 2 -A-CH 2 —CH 2 —B—; —CH 2 —CH 2 -CH 2 -A-CH 2 —CH 2 —; —CH 2 —CH 2 -CH 2 —CH 2 -A-CH 2 —; -A-CH 2 —CH 2 —B—CH 2 —CH 2 —; —CH 2 -A-CH 2 —CH 2 -B-CH 2 —; —CH 2 -A-CH 2 —CH 2 -CH 2 —B—; —CH 2 —CH 2 -A-CH 2 —CH 2 —B—; —O—CH 2 —CH(OCH 3 )—CH 2 —O—; —O—CH 2 —CH(CH 3 )—CH 2 —O—; —O—CH 2 —CH(CF 3 )—CH 2 —O—; —O—CH 2 —C(CH 3 ) 2 —CH 2 -O—; —O—CH 2 —C(CH 3 ) 2 —O—; —O—C(CH 3 ) 2 —CH 2 —O—; —O—CH 2 —CH(CH 3 )—O—; —O—CH(CH 3 )—CH 2 —O—; —O—CH 2 —C(CH 2 CH 2 )—O—; or —O—C(CH 2 CH 2 )—CH 2 —O—; A and B independently represent —O— or —S—; U represents unsubstituted aryl; mono-, di-, tri- or tetra-substituted aryl wherein the substituents are independently selected from the group consisting of halogen, alkyl, alkoxy, and —CF 3 ; or mono-, di-, or tri-substituted heteroaryl wherein the substituents are independently selected from the group consisting of halogen, alkyl, alkoxy, and —CF 3 ; Q represents methylene or ethylene; M represents an aryl, quinolinyl, isoquinolinyl, dihydroquinolinyl or tetrahydroquinolinyl group wherein said groups can optionally be mono- or di-substituted with substituents independently selected from the group consisting of alkyl, alkoxy, —OCF 3 , —CF 3 , hydroxy-alkyl, halogen, alkyl-O—(CH 2 ) 0-4 —CH 2 —, alkyl-O—(CH 2 ) 2-4 —O—, R′ 2 N—(CH 2 ) 0-4 —CH 2 —, and R′″NH—C(═O)—(O) 0-1 —(CH 2 ) 0-4 —CH 2 —, wherein R′ is independently selected from the group consisting of hydrogen, alkyl (optionally substituted by one, two or three fluorine atoms), cyclopropyl, cyclopropyl-methyl, —C(═O)O—R″, and —C(═O)—R″, wherein R″ is C 1 -C 4 -alkyl, —CF 3 , —CH 2 —CF 3 or cyclopropyl; and wherein R′″ is alkyl or cyclopropyl; R 1 represents cycloalkyl; n is the integer 0; r is the integer 3, 4, 5, or 6; s is the integer 2, 3, 4, or 5; t is the integer 1, 2, 3, or 4; u is the integer 1, 2, or 3; and v is the integer 2, 3, or 4; in free or pharmaceutically acceptable salt form, wherein the configurations at positions 3 and 4 of the piperidine ring of the compound of formula (I) are 3R and 4S, respectively.