Patent ID: 8268592

Claim:
A monoclonal antibody or fragment thereof which specifically binds to a native three-dimensional structure of an extracellular region of system ASC amino acid transporter 2 (ASCT2), wherein said monoclonal antibody or fragment thereof comprises complementarity determining regions (CDRs) of a heavy chain variable region (VH) and a light chain variable region (VL), and wherein (A) CDR1, CDR2 and CDR3 of VH of the antibody comprise the amino acid sequences of SEQ ID NOs:26, 27 and 28, respectively, and CDR1, CDR2 and CDR3 of VL of the antibody comprise the amino acid sequences of SEQ ID NOs:29, 30 and 31, respectively; (B) CDR1, CDR2 and CDR3 of VH of the antibody comprise the amino acid sequences of SEQ ID NOs:32, 33 and 34, respectively, and CDR1, CDR2 and CDR3 of VL of the antibody comprise the amino acid sequences of SEQ ID NOs:35, 36 and 37, respectively; or (C) CDR1, CDR2 and CDR3 of VH of the antibody comprise the amino acid sequences of SEQ ID NOs:49, 50 and 51, respectively, and CDR1, CDR2 and CDR3 of VL of the antibody comprise the amino acid sequences of SEQ ID NOs:52, 53 and 54, respectively.