Patent ID: 7569657

Claim:
A method of preparing a polymer having a terminal amine, comprising: a) reacting a substantially non-antigenic polymer of the formula (I) R 3 —R 2 —R 1 (I) wherein R 1 is a reactive polymer terminal group; R 2 is a substantially non-antigenic polymer; and R 3 is a capping group or R 1 ; with a protected amine salt to form a polymer containing a terminal protected amine; and b) reacting the polymer containing the terminal protected amine resulting from step a) with an acid to remove the protecting group and form the polymer having a terminal amine, wherein the protected amine salt has the formula MNP 1 R 4 wherein M is lithium, sodium or potassium; P is selected from the group consisting of C(O)OMe, C(O)OBzl, C(O)OtBu, C(O)OCH 2 CCl 3 , P(O)(OEt) 2 , and CPh 3 ; and R 4 is selected from the group consisting of P 1 , C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy, etc.