Patent ID: 8119691

Claim:
A method for treating airway hyper-responsiveness comprising the step of administering to a subject in need thereof, a therapeutically effective amount of a lipoxin analog having the formula wherein X is R 1 , OR 1 , or SR 1 ; wherein R 1 is (i) a hydrogen atom; (ii) an alkyl of 1 to 8 carbon atoms, inclusive, which may be straight chain or branched; (iii) a cycloalkyl of 3 to 10 carbon atoms; (iv) an aralkyl of 7 to 12 carbon atoms; (v) phenyl; (vi) substituted phenyl wherein Z i , Z ii , Z iii , Z iv and Z v are each independently selected from —NO 2 , —CN, —C(═O)—R 1 , —SO 3 H, a hydrogen atom, halogen, methyl, —OR x , wherein R x is 1 to 8 carbon atoms, inclusive, which may be a straight chain or branched, and hydroxyl; (vii) a detectable label molecule; or (viii) a straight or branched chain alkenyl of 2 to 8 carbon atoms, inclusive; wherein Q 1 is (C═O), SO 2 or (CN), provided when Q 1 is CN, then X is absent; wherein one of R 2 and R 3 is a hydrogen atom and the other is (a) H; (b) an alkyl of 1 to 8 carbon atoms, inclusive, which may be a straight chain or branched; (c) a cycloalkyl of 3 to 6 carbon atoms, inclusive; (d) an alkenyl of 2 to 8 carbon atoms, inclusive, which may be straight chain or branched; or (e) R a Q 2 R b wherein Q 2 is —O— or —S—; wherein R a is alkylene of 0 to 6 carbon atoms, inclusive, which may be straight chain or branched and wherein R b is alkyl of 0 to 8 carbon atoms, inclusive, which may be straight chain or branched, provided when R b is 0, then R b is a hydrogen atom; wherein R 4 is (a) H; (b) an alkyl of 1 to 6 carbon atoms, inclusive, which may be a straight chain or branched; wherein R 5 is wherein Z i , Z ii , Z iii , Z iv and Z v are each independently selected from —NO 2 , —CN, —C(═O)—R 1 , —SO 3 H, a hydrogen atom, halogen, methyl, —OR x , wherein R x is 1 to 8 carbon atoms, inclusive, which may be a straight chain or branched, and hydroxyl or a substituted or unsubstituted, branched or unbranched alkyl group; wherein R 6 is (a) H; (b) an alkyl from 1 to 4 carbon atoms, inclusive, straight chain or branched; wherein T is O or S, and pharmaceutically acceptable salts thereof.