Patent ID: 8658203

Claim:
A method for treating a brain tumor in a mammal, the method comprising: (a) providing a liposomal formulation comprising liposomes in a medium, the liposomes having an interior aqueous space separated from the medium by a membrane, the membrane comprising lipids, the lipids comprising an uncharged lipid component and a neutral phospholipid, with, entrapped inside the liposomes: 1) irinotecan and sucrose octasulfate, or 2) irinotecan and sucrose octasulfate and a substituted ammonium compound, or 3) irinotecan and inositol hexaphosphate, or 4) irinotecan and inositol hexaphosphate and a substituted ammonium compound, wherein the irinotecan entrapped inside the liposomes is at a concentration that exceeds the irinotecan concentration in the medium; and (b) administering the liposomal formulation to the mammal via a conduit placed into the brain tissue of the mammal.