Patent ID: 8859469

Claim:
A protein chip comprising: a substrate having a plurality of steps which are regularly arranged on one surface thereof; a plurality of metallic microstructures arranged in the steps; and a lipid vesicle bound to each of the plurality of metallic microstructures, each lipid vesicle having a lipid bilayer and a functional group arranged on an outer surface thereof, where a membrane protein selected from the group consisting of an ion channel receptor, a G-protein coupled receptor, and an ion channel is present in the lipid bilayer, wherein the metallic microstructures and the lipid vesicles are bound via the functional group to provide the protein on the substrate, wherein a density of the metallic microstructures is 10 12 to 10 14 per m 2 , and wherein the lipid vesicles are arranged on the substrate at a density of 10 12 to 10 14 vesicles per m 2 .