Patent ID: 7098222

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein: Y is N; Y′ is CH; or CF; X, X′, Z, and Z′ are each; R 1 is a group of the formula -L 2 -R 6a -L 3 -R 6b ; R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halogen, cyano, and thioalkoxy; R 3 is absent when X′ is N or R 3 is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, cyano, and thioalkoxy; R 3a is selected from the group consisting of hydrogen, methyl, alkoxy, halogen, and cyano; R 3b is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, hydroxy, cyano, and thioalkoxy; R 4 and R 5 are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, and (NR A R B )alkyl, or R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the formula: R 7 , R 8 , R 9 , and R 10 at each occurrence are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl; or one of the pair R 7 and R 8 or the pair R 9 and R 10 is taken together to form a C 3 –C 6 ring, wherein 0, 1, or 2 heteroatoms selected from O, N, or S replace a carbon atom in the ring; R 11 , R 12 , R 13 , and R 14 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro; R 6a and R 6b are each independently selected from the group consisting of a 5- to 6-membered heteroaryl, a 6-membered aryl, and a 5- to 6-membered heterocycle; Q is selected from the group consisting of a bond, O, S, and NR 15 ; L is —[C(R 16 )(R 17 )] k —; L 2 is selected from the group consisting of a bond, —O—, —C(═O)—, —S—, —[C(R 18 )(R 19 )] q —, —O—[C(R 18 )(R 19 )] q —, —NH— and —N(alkyl)-; L 3 is selected from the group consisting of a bond, —[C(R 16 )(R 17 )] r O—, —O—, —C(═O)—, —S—, —[C(R 18 )(R 19 )] q —, —O—[C(R 18 )(R 19 )] q —, —NH— and —N(alkyl)-; R 15 is selected from the group consisting of hydrogen, alkyl, acyl, alkoxycarbonyl, amido, and formyl; R 16 and R 17 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro; R 18 and R 19 at each occurrence are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, and fluoro; R x and R y at each occurrence are independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, alkylamino, dialkylamino, and fluoro, or one of R x or R y represents a covalent bond when taken together with R x or R y on an adjacent carbon atom such that a double bond is represented between the adjacent carbon atoms; k is an integer from 1 to 6; m is an integer from 1 to 5; p is an integer from 2 to 6; q is an integer from 1 to 4; and r is an integer from 1 to 2.