Patent ID: 8524763

Claim:
A pharmaceutical composition comprising a pharmaceutically acceptable diluent, excipient or binder, and a compound of Formula (I): wherein: L is a bond; R is hydrogen, CO 2 R 1 , an optionally substituted heteroaryl, or an optionally substituted heterocycloalkyl; R 1 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, phenyl or benzyl; R 2 is cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, or heteroarylalkenyl, wherein cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, or heteroarylalkenyl is optionally substituted with at least one R 5 ; R 3 and R 6 are each independently hydrogen, C 1 -C 6 alkyl, —C(O)—C 1 -C 6 alkyl, or —C(O)NR 1 —C 1 -C 6 alkyl, wherein C 1 -C 6 alkyl is optionally substituted with at least one R 5 ; R 4 is aryl or heteroaryl; wherein aryl or heteroaryl is optionally substituted with at least one R 5 ; each R 5 is independently selected from F, Cl, Br, I, —CN, alkyne, C 1 -C 6 alkylalkyne, —NO 2 , —OH, —CF 3 , —OCF 3 , —OR 8 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 8 heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —NHS(═O) 2 R 8 , —S(═O) 2 N(R 9 ) 2 , —N(R 9 )S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 8 , —N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —N(R 9 )C(═O)N(R 9 ) 2 , —N(R 9 )C(═O)OR 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —OC(═O)N(R 9 ) 2 , —CON(R 9 ) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 2 R 8 ; each R 8 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; and each R 9 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; or pharmaceutically acceptable salt thereof.