Patent ID: 7893107

Claim:
A method for treating a disease or condition selected from the group consisting of alcohol gastropathy and, non-steroidal anti-inflammatory drug-induced gastropathy, comprising administering to a subject in need thereof a therapeutically effective amount of a prostaglandin EP 4 agonist component wherein the prostaglandin EP 4 agonist component is selected from the group consisting of prostaglandin EP 4 agonists, pharmaceutically acceptable salts of prostaglandin EP 4 agonists, pro-drugs of prostaglandin EP 4 agonists selected from ethers, esters, cyclodextrins, and amino acids and mixtures thereof wherein the prostaglandin EP 4 agonists are selected from the group consisting of and mixtures thereof; wherein a dashed line indicates the presence or absence of a bond; A is —(CH 2 ) 6 —, cis-CH 2 CH═CH—(CH 2 ) 3 —, —CH 2 C≡C—(CH 2 ) 3 — or —(CH 2 ) m —Ar—(CH 2 ) o — wherein Ar is interarylene, the sum of m and o is from 1 to 4; X is S or O; J is C═O, CHOH or CH 2 CHOH; and E is C 1-12 alkyl, R 2 , or —Y—R 2 , wherein Y is CH 2 , S or O, and R 2 is CH 2 -naphthyl, CH 2 -biphenyl, CH 2 -(2-thienyl), CH 2 -(3-thienyl), naphthyl, biphenyl, 2-thienyl, 3-thienyl, CH 2 -(2-(3-chlorobenzothienyl)), CH 2 -(3-benzothienyl), 2-(3-chlorobenzothienyl), or 3-benzothienyl.