Patent ID: 6933311

Claim:
A compound of formula (I) of a pharmaceutically acceptable salt or prodrug thereof, wherein - - - is absent or is a single bond; X 1 is CR 1 ; X 2 is selected from the group consisting of N and NR 2 ; X 3 is selected from the group consisting of N and NR 3 ; X 4 is a bond; X 5 is N; Z 1 is O; L is selected from the group consisting of alkenylene, alkylene, alkynylene, cycloalkylene, —(CH 2 ) m O(CH 2 ) n —, and N(R y ), wherein the left end of —(CH 2 ) m O(CH 2 ) n — is attached to Z 2 and the right end is attached to R 9 ; m and n are each independently 1-6; R y is selected from the group consisting of hydrogen and alkyl; R 1 , R 3 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, carboxy, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, —S(O) 2 OR A , —S(O) 2 RB, —NZ A Z B , (Z A Z B N)alkyl-, (Z A Z B N)carbonyl-, (Z A Z B N)carbonylalkyl-, and (Z A Z B N)sulfonyl-, wherein Z A and Z B are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, formyl, aryl, and arylalkyl; R 2 is independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, —NR A S(O) 2 R B , —S(O) 2 OR A , S(O) 2 RB, NZ A Z B , (Z A Z B N)alkyl, (Z A Z B N)carbonyl, (Z A Z B N)carbonylalkyl, and (Z A Z B N)sulfonyl; R A is selected from the group consisting of hydrogen and alkyl; R B is selected from the group consisting of alkyl, aryl, and arylalkyl; R 8a is selected from the group consisting of hydrogen and alkyl; R 8b is absent when X 5 is N; and R 9 is selected from the group consisting of hydrogen, aryl, cycloalkyl, and heterocyclyl; with the proviso that variables X 2 and X 3 are not simultaneously NR 2 and NR 3 .