Patent ID: 8569493

Claim:
A method for modulating glucocorticoid receptor activity comprising administering a pharmacologically effective amount of a compound or a pharmaceutically acceptable salt thereof to a patient, said compound having the following formula (1): wherein R 1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group, a heterocyclic group or an aralkyl group; in the case where R 1 is a lower alkyl group, the lower alkyl group is unsubstituted or substituted with one or a plurality of groups selected from the group consisting of a halogen atom, a heterocyclic group, a carboxy group, a lower alkoxycarbonyl group, a lower alkylamino group, a lower alkylamino group substituted with a lower alkylamino group and a lower alkylamino group substituted with an aryl group; in the case where R 1 is an aryl group, a heterocyclic group or an aralkyl group, the aryl group, the heterocyclic group or the aralkyl group is unsubstituted or substituted with one or a plurality of groups selected from the group consisting of a halogen atom, a lower alkyl group, a hydroxyl group and a lower alkoxy group; R 2 represents a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom or a lower alkyl group; R 4 and R 5 are the same or different and represent a hydrogen atom or a lower alkyl group; R 6 represents a hydrogen atom or a lower alkyl group; R 7 represents a lower cycloalkyl group, an aryl group or a heterocyclic group; in the case where R 7 is an aryl group or a heterocyclic group, the aryl group or the heterocyclic group is unsubstituted or substituted with one or a plurality of groups selected from the group consisting of a halogen atom, a lower alkyl group, a hydroxyl group, a lower alkoxy group and a nitro group; W represents an oxygen atom or NR 8 ; R 8 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents a lower alkylene group; Z represents an oxygen atom, a sulfur atom, NR 9 or OCO; and R 9 represents a hydrogen atom or a lower alkyl group.