Patent ID: 8193176

Claim:
A method for treating diseases that involve histamine H3 receptor selected from the group consisting of dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes, hyperlipidemia, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression and allergic rhinitis, which comprises administering to a patient in need thereof an effective amount of a phenylpyrazole derivative represented by the following formula or a pharmaceutically acceptable salt thereof: wherein R 1 and R 2 are attached to each other together with their adjacent nitrogen atom to form a 5- to 6-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with C 1 -C 6 alkyl), T represents a hydrogen atom or halogen, Z 1 represents —CH 2 —, —O— or —NR 11 — (wherein R 11 represents hydrogen or C 1 -C 6 alkyl), p represents an integer of 0 to 3, r represents an integer of 0 to 2, R 3 represents halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy or oxo (provided that when Z 1 is —CH 2 —, the hydrogen atom(s) may be replaced by R 3 ).