Patent ID: 8129367

Claim:
A compound of formula I where: R 1 is CONR 5 R 6 ; R 2 is R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, alkoxy, or haloalkoxy; R 4 is cycloalkyl; R 5 is alkenylSO 2 , alkynylSO 2 , alkoxyalkylSO 2 , (cycloalkyl)alkylSO 2 , (alkyl)cycloalkylSO 2 , ((cycloalkyl)alkyl)cycloalkylSO 2 , (benzyl)cycloalkylSO 2 , (alkenyl)cycloalkylSO 2 , (alkynyl)cycloalkylSO 2 , (trialkylsilyl)cycloalkylSO 2 , (CO 2 R 7 )cycloalkylSO 2 , (PhCO)cycloalkylSO 2 , (PhN(R 7 )CO)cycloalkylSO 2 , tetrahydrofuranylSO 2 , tetrahydropyranylSO 2 , (tetrahydrofuranyl)alkylSO 2 , (tetrahydropyranyl)alkylSO 2 , isoxazolidinylSO 2 , Ar 1 SO 2 , (Ar 1 )alkylSO 2 , Ar 2 SO 2 , or (CON(R 7 )(R 7 ))alkyl; R 6 is hydrogen or alkyl; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl; Ar 1 is phenyl, pyridinyl, pyrimidinyl, quinolinyl, or isoquinolinyl, and is substituted with 0-3 substituents selected from halo, alkyl, alkoxy, and cyano; and Ar 2 is furanyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, or tetrazolyl, and is substituted with 0-3 substituents selected from halo, alkyl, alkoxy, and cyano; or a pharmaceutically acceptable salt thereof.