Patent ID: 8841309

Claim:
A compound of formula (I), characterized in that R 1 denotes halogen, X − denotes acetate, halide, sulfate, hydrogen sulfate, succinate, malate, hydrogen carbonate, sulfate ×0.5 or carbonate ×0.5, L 1 denotes a group of formula (i), wherein R L1 denotes C 1-6 -alkyl, or R L1 denotes a C 1-6 -alkylene bridge by replacing one of the hydrogen atoms of formula (i), forming a bicyclic ring system, n and m independently from each other denote 1, 2 or 3, L 2 denotes —CH 2 or —CH(C(O)NHR L2 )—, wherein R L2 denotes H, C 1-8 -alkyl, phenyl, C 6-10 -aryl-C 5-6 -cycloalkyl-, C 6-10 -aryl-C 1-4 -alkyl-, HO—C 2-6 -alkyl-, C 1-4 -alkoxy-, C 1-4 -alkoxy-C 2-6 -alkyl, heteroaryl, C-linked hererocyclyl, C-linked herecyclyl-C 1-4 -alkyl, C-linked heterocyclyl-COO—C 1-4 -alkyl-, aryl- heterocyclyl-C 1-4 -alkyl, N-linked heterocyclyl-C 2-4 -alkyl, C 6-10 -aryl-(HOOC)C 1-4 -alkyl-, —CH(C 1-3 -alkyl-C 6-10 -aryl)(COO—C 1-4 -alkyl),—CH(C 1-3 -alkyl-C 6-10 -aryl)(COOH), —C 1-3 -alkyl-C 6-10 -aryl-COO—C 1-4 -alklyl, —C 6-10 -aryl-COO—C 1-4 -alkyl or —C(R 3.1 R 3.2 )phenyl, wherein R 3.1 R 3.2 together with the carbon atom they are attached to form a 5-7 -membered heterocyclyl. L 3 denotes hydrogen, —COOH, —CO-phenyl, —COO—C 1-3 -alkyl, —COO—C 1-3 -alkyl-C 6-10 -aryl-C 6-10 -aryl-COO—C 1-4 -alkyl, —C(O)NR 2 R 3 , heteroaryl, C 1-3 -alkyl, C 2-5 -alkenyl, C 2-3 -alkynyl, C 3-7 -cycloalkyl, C 5-7 -cycloalkenyl, HO—C 1-7 -alkyl-, C 1-4 -alkoxy-C 1-5 -alkyl-, C 1-4 -alkyl-S(O) p —C 1-3 -alkyl-, C-linked heterocyclyl, —CO-heterocyclyl, —CO—heterocyclyl-heteroaryl, —CO—heterocyclyl—COO—C 1-4 -alkyl, —CO-heterocyclyl—COOH—CN, or phenyl of formula (ii), R L3.1 , R L3.2 , R L3.3 , R L3.4 and R L3.5 independently -denote H, —OH, —O—C 1-4 -alkyl, C 1-4 -alkyl, —S—C 1-4 -alkyl, —S—CF 3 , —CF 3 , —O—CH 2 -phenyl, —O—CF 3 , —CH 2 —OH, —CH 2 COOH, halogen, —SO 2 —C 1-4 -alkyl , —COO—C 1-4 -alkyl, —CONH 2 , —C 1-4 -alkyl-phenyl-CN, —CONHC 1-4 -alkyl, —CON(C 1-4 -alkyl) 2 , —CO—NH-heterocyclyl, or CN, wherein, p is 0, 1 or 2, R 2 and R 3 independently denote H, C 1-8 -alkyl, phenyl, C 6-10 -aryl-C 5-6 -cycloalkyl-, C 6-10 -aryl-C 1-4 -alkyl- wherein said C 6-10 -aryl may be substituted with —Cl, —CN, —C(O)OCH 3 , or —C(O)OH, HO—C 2-6 -alkyl-, C 1-4 -alkoxy-, C 1-4 -alkoxy-C 2-6 -alkyl-, heteroaryl, C-linked heterocyclyl, C-linked heterocyclyl-C 1-4 -alkyl, C-linked heterocyclyl —COO—C 1-4 -alkyl-, aryl-C-linked heterocyclyl-C 1-4 -alkyl, N-linked heterocyclyl-C 2-4 -alkyl, C 6-10 -aryl-(HOOC)C 1-4 -alkyl-, —CH(C 1-3 -alkyl-C 6-10 -aryl)(COO—C 1-4 -alkyl), —CH(C 1-3 -alkyl-C 6-10 -aryl)(COOH), —C 1-3 -alkyl-C 6-10 -aryl-COO—C 1-4 -alkyl, —C 6-10 -aryl-COO—C 1-4 -alkyl or —C(R 3.1 R 3.2 )phenyl, wherein R 3.1 R 3.2 together with the carbon atom they are attached to form a 5-7-membered heterocyclyl, or R 2 and R 3 together with the nitrogen atom they are attached to form a 5-7-membered heterocyclyl, optionally substituted by a carboxylic acid or a heterroaryl, and tautomers and pharmaceutically acceptable salts thereof.