Patent ID: 6846828

Claim:
A compound having the formula: wherein one of either V or X is N and the other is —CR a , or both V and X are —CR a (where each R a is independently hydrogen, alkyl, cycloalkyl or cycloalkylalkyl; Y is selected from the group consisting of O, S and NR; wherein R is selected from the group consisting of H, CN, NO 2 , (C 1 -C 10 )alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-alkyl, (C 3 -C 10 )alkenyl and (C 2 -C 10 )alkynyl; Z is selected from the group consisting of H, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 6 )cycloalkyl-alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and N(R 2 )(R 3 ); R 1 is selected from the group consisting of H, (C 1 -C 10 )alkyl, (C 3 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-alkyl, (C 1 -C 10 )heteroalkyl, heterocyclyl, heterocyclylalkyl, aryl, aryl(C 1 -C 4 )alkyl, aryl(C 1 -C 4 )heteroalkyl, heteroaryl(C 1 -C 4 )alkyl, heteroaryl(C 1 -C 4 )heteroalkyl, —C(O)R 11 and alkylene-C(O)R 11 ; R 11 is hydrogen, (C 1 -C 6 )alkyl or NR 12 R 13 (where R 12 and R 13 are independently hydrogen, (C 1 -C 6 )alkyl or heteroalkyl); R 2 and R 3 are each members independently selected from the group consisting of H, (C 1 -C 10 )alkyl, (C 3 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-alkyl and (C 1 -C 10 )heteroalkyl, or R 2 and R 3 can be combined to form a 5-7-membered heterocyclyl ring; R 4 is selected from the group consisting of H, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-alkyl, (C 2 -C 6 )alkenyl and (C 2 -C 6 )alkynyl; A is selected from the group consisting of H, (C 1 -C 10 )alkyl, (C 1 -C 10 )haloalkyl, (C 3 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-alkyl, (C 1 -C 10 )heteroalkyl, heterocyclyl, heterocyclylalkyl, heterosubstituted cycloalkyl, aryl, aryl(C 1 -C 4 )alkyl, aryl(C 1 -C 4 )heteroalkyl, heteroaryl, heteroaryl(C 1 -C 4 )alkyl, heteroaryl(C 1 -C 4 )heteroalkyl and R a NHC(═X)— wherein R a is (C 1 -C 4 )alkyl or aryl and X is O or S; B is a substituted or unsubstituted five- or six-membered aromatic ring containing at least one nitrogen atom, and from 0 to 3 additional heteroatoms, wherein the B ring substituents are selected from the group consisting of halogen, CF 3 , CF 3 O, (C 1 -C 6 )alkyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, cyano, nitro, sulfonamido, acyl, acylamino and carboxamido; U is NR 5 , O or S; and, R 5 is H or (C 1 -C 6 )alkyl.