Patent ID: 7566716

Claim:
A compound of Formula I, stereoisomers, tautomers or pharmaceutically acceptable salts thereof, wherein: X is NR 5 ; R 1 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, cycloalkyl, heterocycloalkyl, Z n -aryl, or heteroaryl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl portions are optionally substituted with one or more groups independently selected from F, Cl, Br, I, NO 2 , oxo (with the proviso that it is not on said aryl or heteroaryl), alkyl, Z n -aryl, Z n -heterocycloalkyl, Z n -heteroaryl, Z n -CN, Z n -OR 12 , Z n -C(O)R 12 , Z n -C(O)OR 12 , Z n -C(O)-heterocycloalkyl, Z n -NR 15 R 15 , Z n -NR 12 C(O)R 13 , Z n -NR 12 C(O)OR 13 , Z n -SR 12 , Z n -SOR 12 , Z n -SO 2 R 12 , Z n -O—(C 1 -C 6 alkyl)-C(O)NR 12 R 13 , Z n -O—(C 1 -C 6 alkyl)-C(O)OR 12 , Z n -O—(C 1 -C 6 alkyl)-heterocycloalkyl, Z n -O—(C 1 -C 6 alkyl)-C(O)-heterocycloalkyl, Z n -C(O)NR 12 R 13 , Z n -NR 12 —(C 1 -C 6 alkyl)-C(O)NR 12 R 13 , Z n -NR 12 —(C 1 -C 6 alkyl)-C(O)OR 12 , Z n -NR 12 —(C 2 -C 6 alkyl)-OC(O)NR 12 R 13 , Z n -NR 12 C(═O)NR 13 Z n -R 16 , and Z n -NR 12 —(C 2 -C 6 alkyl)-NR 12 C(O)NR 12 R 13 ; R 2 , R 3 and R 4 are; R 5 is H, or C 1 -C 10 alkyl; wherein (i) R 7 and R 8 form a 5 or 6 membered fused carbocyclic ring substituted with ═Y, and R 9 , R 10 and R 11 are independently selected from H, F, Cl, Br, and I, or (ii) R 8 and R 9 form a 5 or 6 membered fused carbocyclic ring substituted with ═Y, and R 7 , R 10 and R 11 are independently selected from H, F, Cl, Br, and I; Y is O or N—OH; R 12 , R 13 and R 14 are independently selected from H, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from halogen, OH, O-alkyl, amino, alkylamino and dialkylamino; R 15 is H, —SO 2 -alkyl, —SO 2 NR 13 R 14 , (C 1 -C 6 alkyl)-OH, —C(O)O-alkyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl portions are optionally substituted with one or more groups independently selected from halogen, OH, O-alkyl, amino, alkylamino and dialkylamino; R 16 , is heteroaryl that is substituted with one or more alkyl, alkenyl, or alkynyl; Z is alkylene having from 1 to 4 carbons, or alkenylene or alkynylene each having from 2 to 4 carbons, wherein said alkylene, alkenylene and alkynylene are optionally substituted with one or more groups independently selected from halogen, OH, O-alkyl, and amino; and n is 0, 1, 2, 3 or 4.