Patent ID: 7626031

Claim:
A compound represented by formula I, or a single stereoisomer, a single geometric isomer, a mixture of enantiomers, or a mixture of diastereomers thereof; and where the compound is optionally as a pharmaceutically acceptable salt thereof, and wherein, each W is CR 1 ; each R 1 is independently selected from —H and —A—R 7 ; provided one of R 1 is —A—R 7 and is located at the 5-position of the indolinone ring, wherein, only for said —A—R 7 , R 7 must be a piperidin-4-yl, and where the nitrogen of the piperidin-4-yl of —A—R 7 is optionally substituted with one group selected from alkyl, arylalkyl, pyrrolidinylethyl, piperidinylethyl, morpholinylethyl, and sulfonyl; A is NH; L is NR 3 ; Q is C; R 2 and R 3 are each —H; R 4 and R 5 are each independently selected from —H, —OR 6 , —NR 6 R 7 , —S(O) 0-2 R 6 , —SO 2 NR 6 R 7 , —CO 2 R 6 , —C(O)NR 6 R 7 , —N(R 6 )SO 2 R 6 , —C(O)R 7 , —CN, —NO 2 , —NH 2 , halogen, trihalomethyl, alkyl, 1,3-dioxo-isoindol-2-ylethyl, and aryl; or R 4 and R 5 , when taken together, form a six-membered aromatic ring system containing zero nitrogens, said six-membered aromatic ring system is optionally substituted with between zero and four of R 15 ; R 6 is selected from —H, and C 1-8 alkyl; R 7 , for other than R 7 in —A—R 7 , is selected from —H, and C 1-8 alkyl; R 8 is —H, —NO 2 , —CN, —OR 6 or C 1-8 alkyl; X is selected from one of the following formulae: wherein m is zero to five, n is zero to three, and Z is CR 10 ; R 10 is selected from —H, halogen, trihalomethyl, —NH 2 , —NO 2 , —OR 6 , —N═CNR 6 R 7 , —NR 6 R 7 , —N(R 6 )C(═NR 8 )NR 6 R 7 , —SR 6 , —S(O) 1-2 R 6 , —SO 2 NR 6 R 7 , —CO 2 R 6 , —C(O)NR 6 R 7 , —C(O)N(OR 6 )R 7 , —C(═NR 8 )NR 6 R 7 , —N(R 6 )SO 2 R 6 , —C(O)R 7 , and R 7 ; K is O; and each R 15 is independently selected from —H, halogen, —OR 6 , and C 1-8 alkyl.