Patent ID: 7906619

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, where R 1 and R 2 are joined to form a 5- to 7-membered heterocyloalkyl ring containing 1 or 2 heteroatoms independently chosen from N, O, and S which ring is optionally fused to a phenyl or 5- or 6-membered heteroaryl to form a bicyclic ring system, each of which 5- to 7-membered heterocycloalkyl ring or bicyclic ring system is optionally substituted; R 3 , R4, R5, and R 6 are independently hydrogen, C 1 -C 4 alkyl, or (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl; R 7 and R 8 are joined to form an optionally substituted 3- to 7-membered cycloalkyl ring; T is a group of the formula: R 9 is hydroxyl, amino, —COOH, —NR 10 R 11 , —OR 12 , —SR 12 , —NR 10 (S═O)R 11 , or —NR 10 SO 2 R 11 , R 10 , R 11 , and R 12 are independently at each occurrence hydrogen, or C 1 -C 6 alkyl, C 2 -C 6 alkenyl, (aryl)C 0 -C 2 alkyl, (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl, (heterocycloalkyl)C 0 -C 2 alkyl, or (5- to 10-membered heteroaryl)C 0 -C 2 alkyl, each of which is substituted with 0 to 3 substituents independently chosen from halogen, hydroxyl, oxo, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, trifluoromethyl, and trifluoromethoxy: Z is where X 1 , X 2 , X 3 , X 4 , and X 5 are independently N or CH and no more than two of X 1 -X 5 are N; R 21 represents from 0 to 3 groups independently chosen from halogen, hydroxyl, amino, cyano, —CONH 2 , —COOH, C 1 -C 4 alkyl, C 2 -C 4 alkanoyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, mono- and di-C 1 -C 4 alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 22 is hydrogen, halogen, hydroxyl, amino, cyano, —CONH 2 , —COOH, C 1 -C 4 alkyl, C 2 -C 4 alkanoyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, mono- and di-C 1 -C 4 alkylamino, C 1 -C 4 alkylester, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, or R 22 is (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl, (phenyl)C 0 -C 2 alkyl, (phenyl)C 0 -C 2 alkoxy, (5- or 6-membered heteroaryl)C 0 -C 2 alkyl, (5- or 6-membered heteroaryl)C 0 -C 2 alkoxy, naphthyl, indanyl, (5- or 6-membered heterocycloalkyl)C 0 -C 2 alkyl, or 9- or 10 membered bicyclic heteroaryl, each of which is substituted with 0, 1, or 2 substituents independently chosen from (i) halogen, hydroxyl, amino, cyano, nitro, —COOH, —CONH 2 , CH 3 (C═O)NH—, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 hydroxyalkyl, mono- and di-C 1 -C 4 alkylamino, —NR 8 SO 2 R 11 , —C(O)OR 11 , —NR 8 COR 11 , —NR 8 C(O)OR 11 , trifluoromethyl, trifluoromethoxy, and (ii) phenyl and 5- or 6-membered heteroaryl, each of which is substituted with 0 or 1 or more of halogen, hydroxyl, C 1 -C 4 alkyl, C 1 -C 2 alkoxy; and R 16 represents 0 to 4 substituents is independently chosen at from halogen, C 1 -C 2 alkyl, and C 1 -C 2 alkoxy.