Patent ID: 8680116

Claim:
A compound of the formula I: wherein: R 1 is selected from the group consisting of: (1) —C 5-6 heterocycle selected from the group consisting of thiophenyl and pyridyl, which is unsubstituted or substituted with R 14 , provided that when R 1 is thiophenyl and R 2 is —O(CH 2 ) n C 5-10 heterocycle then n is 0-1; and when R 1 is thiophenyl and R 2 is —OCH 3 then R 3 and R 4 are not both hydrogen; (2) phenyl, which is unsubstituted; (3) —C 1-6 alkyl, which is unsubstituted or substituted with R 14 ; R 2 is selected from the group consisting of: (1) —O(C 1-6 alkyl), unsubstituted or substituted with R 14 ; (2) —O(CH 2 ) n C 6-10 aryl, which is unsubstituted or substituted with R 14 ; (3) —O(CH 2 ) n C 3-10 cycloakyl; (4) —O(CH 2 ) n C 5-10 heterocycle, which is unsubstituted or substituted with R 14 , (5) phenyl, substituted with R 14 ; (6) —(CH 2 ) n C 5-10 heterocycle, which is unsubstituted or substituted with R 14 , provided said heterocycle is not thiophenyl; (7) —(CH 2 ) n C 5-10 aryl, which is unsubstituted or substituted with R 14 ; (8) —(CH 2 ) n C 3-10 cycloakyl; (9) —(C 2-6 alkenyl)C 5-10 heterocycle, which is unsubstituted or substituted with R 14 ; (10) —(C 2-6 alkenyl)C 6-10 aryl, which is unsubstituted or substituted with R 14 ; (11) —(C 2-6 alkenyl)C 3-10 cycloalkyl, which is unsubstituted or substituted with R 14 ; R 3 is selected from the group consisting of: (1) Hydrogen (2) Halogen (3) —C 6-10 aryl, which is unsubstituted or substituted with R 14 ; (4) —C 5-10 heteroaryl, which is unsubstituted or substituted with R 14 ; (5) -(Q)C 6-10 aryl, which is unsubstituted or substituted with R 14 ; (6) -(Q)C 5-10 heteroaryl, which is unsubstituted or substituted with R 14 ; (7) -(Q)-C(R 5 ,R 6 )—OH; (8) —CN; (9) —C 2-4 alkenyl; (10) —OC 1-6 alkyl; Q is selected independently from: a. —C 1-6 alkyl; b. —C 2-4 alkynyl; c. —C 2-4 alkenyl; R 4 , is selected independently from (1) Hydrogen; (2) —(CH 2 ) n CH 3 ; (3) —OC 1-6 alkyl; (4) Halogen R 5 and R 6 are selected independently from (1) Hydrogen; (2) —(CH 2 ) n CH 3 ; (3) —OC 1-6 alkyl; R 14 is selected from the group consisting of: (1) Hydroxyl; (2) Halogen; (3) C 1-6 alkyl; (4) —CN; (5) —CO 2 H; (6) —C(O)NH 2 ; (7) —(CH 2 ) n C 6-10 aryl; (8) —(CH 2 ) n C 5-10 heterocycle; (9) —NO 2 ; (10) -(Q)-C(R 5 ,R 6 )—OH; (11) -Q(CH 2 ) n C 6-10 heteroaryl, which is unsubstituted or substituted with R 15 ; (12) —(CH 2 ) n C 3-10 cycloakyl; (13) -Q(CH 2 ) n C 6-10 aryl, which is unsubstituted or substituted with R 15 ; R 15 is selected from the group consisting of: (1) Hydroxyl; (2) Halogen; (3) C 1-6 alkyl; (4) —CN; and n is 0-3; or a pharmaceutically acceptable salt thereof.