Patent ID: 8163789

Claim:
A compound according to formula I wherein said compound is an optionally substituted imidazole that antagonizes a MDM2/p53 or MDM4/p53 complex, wherein: R1 is optionally substituted (C 3 -C 8 )aryl, (C 3 -C 8 )heterocycloalkyl, (C 3 -C 8 ) heteroaryl, (C 1 -C 6 )alkyl(C 3 -C 8 )aryl, (C 3 -C 8 )aryl(C 1 -C 6 )alkyl, optionally substituted benzyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl and (C 3 -C 8 )cycloalkyl; R2 is optionally substituted (C 3 -C 8 )aryl, optionally substituted (C 3 -C 8 )heteroaryl, optionally substituted (C 3 -C 8 )heterocycloalkyl, (C 3 -C 8 )heteroaryl(C 1 -C 6 )alkyl and (C 3 -C 8 )heterocycloalkyl(C 1 -C 6 )alkyl; R3 is optionally substituted (C 3-8 )aryl, aryl(C 1 -C 6 )alkyl, optionally substituted benzyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl; and R4 is NRR′(C 1 -C 8 )alkyl; and R and R′ are independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl and (C 3 -C 8 )cycloalkyl.