Patent ID: 8071597

Claim:
A compound according to Formula (I), wherein: A, B, D and E, each of which may be optionally substituted, are C, such that the ring R is an aromatic ring; R 1 is selected from H, halogen, nitro, optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl or optionally substituted C 2 -C 6 -alkynyl; R 2 is selected from H, optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl or optionally substituted C 2 -C 6 -alkynyl; R 3 is selected from H, halo, optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl, optionally substituted C 2 -C 6 -alkynyl, optionally substituted alkoxy, optionally substituted aryl or optionally substituted heteroaryl; R 4 is selected from optionally substituted C 1 -C 6 -alkyl, optionally substituted C 2 -C 6 -alkenyl, optionally substituted C 2 -C 6 -alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl C 1 -C 6 -alkyl, optionally substituted heteroaryl C 1 -C 6 -alkyl, optionally substituted C 3 -C 8 cycloalkyl optionally substituted C 1 -C 6 -alkyl, optionally substituted heterocycloalkyl C 1 -C 6 -alkyl, optionally substituted aryl C 2 -C 6 -alkenyl or optionally substituted heteroaryl C 2 -C 6 -alkenyl; n is an integer selected from 0, 1, 2, 3 and 4; an optionally substituted group may be substituted with from 1 to 5 substituents selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, cycloalkyl, heterocycloalkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, amino, ammonium, acyl, acyloxy, acylamino, aminocarbonyl, alkoxycarbonyl, ureido, aryl, carbamate, heteroaryl, sulfinyl, sulfonyl, alkoxy, sulfanyl, halogen, carboxy, trihalomethyl, cyano, hydroxy, mercapto and nitro; with the first proviso that when R 4 is thiophenyl, it is not selected from group consisting of: unsubstituted thiophenyl, unsubstituted chloro-5-thiophenyl and unsubstituted bromo-5-thiophenyl; with the second proviso that when R 4 is a phenyl, it is a mono-substituted phenyl that is not selected from the group consisting of: p-bromo phenyl; p-methoxy phenyl; p-ethoxy phenyl; o-, m- or p-chloro phenyl; m- or p-methyl phenyl; o- or p-fluoro phenyl; o-CF3-phenyl; p- or m-nitro phenyl; p-NHAc-phenyl and p-amino phenyl; or it is a multi-substituted phenyl, that is not an unsubstituted bi-substituted phenyl selected from the group consisting of: m-, p-dimethyl phenyl; m-, m-dimethyl phenyl; o-, p-dimethyl phenyl; o-, m-dimethyl phenyl; o-methyl p-fluoro phenyl; m-, m-dichloro phenyl; o-, m-dichloro phenyl; p-chloro m-nitro phenyl and o-ethoxy m-bromo phenyl; with the final proviso that wherein R 4 is a 1,4 benzodioxin it is a substituted benzodioxin; or an optically active form or a pharmaceutically acceptable salt thereof.