Patent ID: 7319139

Claim:
A kit useful for the treatment of a mammal suffering from or predisposed to a neoplastic disorder comprising at least one container containing substantially purified dimeric antibodies that bind specifically to TAG-72, each dimeric antibody comprising two antibodies that are non-covalently associated to form a tetravalent antibody dimer having four antigen-biding sites that bind specifically to TAG-72, wherein each of the antibodies in the dimer comprises two antibody heavy chain polypeptides having the heavy chain variable region amino acid sequence shown in FIG. 4A (SEQ ID NO: 7), and two antibody light chain polypeptides having the light chain variable region amino acid sequence shown in FIG. 5A (SEQ ID NO: 9), and has two antigen-binding sites that bind specifically to TAG-72; wherein each of the four antibody heavy chain polypeptides in the dimeric antibody comprises a human gamma-1 constant region wherein a C H 2 domain is deleted from, and a C H 3 domain is fused directly to the hinge region; wherein the dimeric tetravalent antibodies are purified to greater than 98% homogeneity; and further comprising a label or an insert indicating that said dimeric antibody may be used to treat said neoplastic disorder.