Patent ID: 8666671

Claim:
A method for creating drug combinations that modulate at least one desired primary response of a cellular receptor and that prevent or reduce at least one undesired secondary response of the cellular receptor, said method comprising the steps of: selecting a first drug known for eliciting the at least one desired primary response; determining biophysical parameters of the first drug over a full range of dose-response curve of the at least one desired primary response; determining biophysical parameters of the first drug for the at least one undesired secondary response; determining a modulated primary response level that is below a theoretical maximal response level of the first drug; selecting a second drug or molecule which modulates the first drug response specific to the cellular receptor at or below the modulated primary response level; determining biophysical parameters of the second drug or molecule for the at least one desired primary response and the at least one undesired secondary response; determining an amount of the second drug or molecule that prevents or reduces the at least one undesired secondary response based at least in part upon the biophysical parameters of the first drug for the full dose-response curve of the at least one desired primary response, based at least in part upon the biophysical parameters of the first drug for the at least one undesired secondary response and at least in part upon the biophysical parameters of the second drug or molecule for the at least one desired primary response and the at least one undesired secondary response, wherein the amount of the second drug or molecule is determined to be a specific ratio of the second drug or molecule to the first drug; and combining a physical amount of the first drug and a physical amount of the second drug or molecule according to the specific ratio to form a composition that elicits the at least one desired primary response and prevents or reduces the at least one undesired secondary response.