Patent ID: 7622494

Claim:
A method for the treatment of HPV infection, genital warts, or cervical dysplasia comprising the administration of a compound of formula (I): wherein: n is 0, 1, or 2; R is hydrogen or alkyl; X is NR 2 , O; each R 1 is the same or different and is independently selected from the group consisting of hydrogen, halogen, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, —R 10 cycloalkyl, Ay, —NHR 10 Ay, Het, —NHHet, —NHR 10 Het, —OR 2 , —OAy, —OHet, —R 10 OR 2 , —NR 2 R 3 , —NR 2 Ay, —R 10 NR 2 R 3 , —R 10 NR 2 Ay, —R 10 C(O)R 2 , —C(O)R 2 , —CO 2 R 2 , —R 10 CO 2 R 2 , —C(O)NR 2 R 3 , —C(O)Ay, —C(O)NR 2 Ay, —C(O)Het, —C(O)NHR 10 Het, —R 10 C(O)NR 2 R 3 , —C(S)NR 2 R 3 , —R 10 C(S)NR 2 R 3 , —R 10 NHC(NH)NR 2 R 3 , —C(NH)NR 2 R 3 , —R 10 C(NH)NR 2 R 3 , —S(O) 2 NR 2 R 3 , —S(O) 2 NR 2 Ay, —R 10 SO 2 NHCOR 2 , —R 10 SO 2 NR 2 R 3 , —R 10 SO 2 R 2 , —S(O) m R 2 , cyano, nitro, or azido; Y is optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted alkenylene, optionally substituted cycloalkenylene, or optionally substituted alkynylene; d is 0 or 1; Z is —R 2 , —OR 2 , —C(O)R 2 , —C(O) 2 R 2 , —S(O) m R 2 , —C(O)NR 2 R 3 , -Het, or -Ay, provided when d is 0, then Z is not -Het or -Ay; each m independently is 0, 1 or 2; each R 10 is the same or different and is independently selected from alkylene, cycloalkylene, alkenylene, cycloalkenylene, and alkynylene; p is selected from 0, 1, 2, 3, or 4; each of R 2 and R 3 are the same or different and are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, —R 10 cycloalkyl, —R 10 OH, —R 10 (OR 10 ) w , and —R 10 NR 5 R 6 ; w is 1-10; each of R 5 and R 6 are the same or different and are independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, and alkynyl; Ay represents an optionally substituted aryl group; Het represents an optionally substituted 5- or 6-membered heterocyclyl or heteroaryl group; or a pharmaceutically acceptable salt thereof to a human in need thereof.