Patent ID: 8664440

Claim:
A method for preparing the Aliskiren intermediate compound of formula XV comprising the steps of (1). reacting the compound of formula IX 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with sequentially added isopropylmagnesium chloride and n-butyllithium in an ether class solvent under temperature of −25° C.-20° C. to obtain the intermediate compound of formula XXII; (2). methylsulfonylation of the compound of formula XIX in an inert. solvent under temperature of −10° C.-25° C. to obtain the compound of formula XX. wherein Ms is methylsulfonyl group. (3). substituting the intermediate compound of formula XX with anhydrous lithium bromide in a ketone class solvent under temperature of 35° C. to refluxing temperature to obtain the intermediate compound of formula XXI; (4). coupling the intermediate compound of formula XXII in step (1) with the intermediate compound of formula XXI in step (3) in an ether class solvent under temperature of −25° C.-55° C. with the presence of iron-contained catalyst to obtain the compound of formula XV; wherein R 1 is tert butoxycarbonyl or benzyloxycarbonyl group in the compounds of formula XV, XIX, XX and XXI in the above reaction steps.