Patent ID: 8552005

Claim:
A substituted 3-(arylsulfonyl)pyrazolo[1,5-a]pyrimidine compound of general formula 1, or a pharmaceutically acceptable salt thereof, wherein: Ar is an optionally substituted aryl; R 1 , R 2 and R 3 independently of each other represent hydrogen, C 1 -C 3 alkyl or phenyl; R 4 is a substituted hydroxy group or a substituted sulfanyl group; with the exception of: 5,7-dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine; 5,7-dimethyl-3-tosylpyrazolo[1,5-a]pyrimidine; 5-methyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine; 3-(1H-1,2,4-triazol-3-ylsulfonyl)-2,5,7-trimethylpyrazolo[1,5-a]pyrimidine; 3-(1H-1,2,4-triazol-3-ylsulfonyl)-2-methoxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine; 3-(1H-1,2,4-triazol-3-ylsulfonyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine; 3-(1H-1,2,4-triazol-3-ylsulfonyl)pyrazolo[1,5-a]pyrimidine; N,N-diethyl-3-(2-methylpyrazolo[1,5-a]pyrimidin-3-ylsulfonyl)-1H-1,2,4-triazol-1-carboxamid; 3-(2,5-dimethylpyrazolo[1,5-a]pyrimidin-3-ylsulfonyl)-N,N-diethyl-1H-1,2,4-triazol-1-carboxamid; N,N-diethyl-3-(pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl)-1H-1,2,4-triazol-1-carboxamid; N,N-diethyl-3-(2,5,7-trimethylpyrazolo[1,5-a]pyrimidin-3-ylsulfonyl)-1H-1,2,4-triazol-1-carboxamid; N,N-diethyl-3-(2-methoxy-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylsulfonyl)-1H-1,2,4-triazol-1-carboxamid; 5,7-dimethyl-3-[(4-methylpiperazin-1-yl)sulfonyl]pyrazolo[1,5-a]pyrimidine.