Patent ID: 7892569

Claim:
A method of altering the uptake of a D-type oligodeoxynucleotide by a cell expressing CXCL16, comprising contacting the cell with an effective amount of an agent, wherein the agent is ionomycin, an antibody that specifically binds CXCL16, or a metalloproteinase inhibitor that is an antagonist of ADAM-10; and contacting the cell with the D-type oligodeoxynucleotide, wherein the D-type oligodeoxynucleotide has the sequence (SEQ ID NO: 21) 5′ X 1 X 2 X 3 Pu 1 Py 2 CpG Pu 3 Py 4 X 4 X 5 X 6 (W) M (G) N -3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10, and wherein the D-type oligodeoxynucleotide is 18 to 50 nucleotides in length.