Patent ID: 7438920

Claim:
A crystallizable composition capable of producing crystals for use in X-ray crystallography comprising: a. an HCV NS3 helicase protein selected from SEQ ID NO:2; fragments of SEQ ID NO:2 comprising at least amino acids 183 to 582; mutants of SEQ ID NO:2 containing one or more of the following amino acid substitutions: Ser231-to-Ala, Thr269-to-Ala, Ser370-to-Ala, Thr411-to-Ala, Trp501-to-Phe, Trp501-to-Leu or Trp501-to-Ala, Gln460-to-Ala, Arg461-to-Ala, Arg462-to-Ala, Arg464-to-Ala, or Arg467-to-Ala; or fragments of SEQ ID NO:2 comprising at least amino acids 183 to 582 and containing one or more, of the following amino acid substitutions: Ser231-to-Ala, Thr269-to-Ala, Ser370-to-Ala, Thr411-to-Ala, Trp501-to-Phe, Trp501-to-Leu or Trp501-to-Ala, Gln460-to-Ala, Arg461-to-Ala, Arg462-to-Ala, Arg464-to-Ala, or Arg467-to-Ala; and b. a single stranded dU oligonucleotide consisting of between 6 and 12 nucleotides.