Patent ID: 7375247

Claim:
A method for producing MMA-d 8 represented by the formula: CD 2 =C(CD 3 )COOCD 3 , the method comprising; (i) preparing methanol-d 3 represented by the formula: CD 3 OH by exchanging D to H in a hydroxyl group of methanol-d 4 represented by the formula: CD 3 OD, (ii) reacting acetone-d 6 and normal hydrocyanic acid to prepare acetone cyanohydrin-d 6 , and treating the acetone cyanohydrin-d 6 by normal non-deuterated sulfuric acid to obtain a sulfuric acid salt of deuterated methacrylic acid amide represented by the formula CD 2 =C(CD 3 )CO(NH 2 .H 2 SO 4 ), (iii) reacting the CD 3 OH with the sulfuric acid salt of deuterated methacrylic acid amide to prepare MMA-d 8 represented by the formula: CD 2 =C(CD 3 )COOCD 3 , and (iv) recovering a deuterium-containing compound generated as a by-product in at least one of steps (i) and (iii), and reutilizing the recovered deuterium-containing compound as at least part of raw materials used for producing at least one of methanol-d 4 or acetone-d 6 of steps (i) and (ii).