Patent ID: 8354424

Claim:
A method of treating actinic keratosis, the method comprising applying topically to an actinic keratosis lesion twice per week for a duration of 8 weeks a formulation comprising: 0.3% by weight of 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine; 0.15% by weight sorbic acid; 5.0% by weight propylene glycol; 0.2% by weight methylparaben; 0.1% by weight butylated hydroxyanisole; 0.05% by weight ethylenediaminetetraacetic acid disodium salt dihydrate; 7.0% by weight isostearic acid; 4.0% by weight of caprylic/capric triglyceride; 1.0% by weight of a carbomer; 3.5% by weight of a poloxamer; 0.8% by weight of an aqueous solution of 20% by weight NaOH in water; and 77.9% by weight water; wherein the weight percentages are based on the total weight of the formulation.