Patent ID: 7491715

Claim:
A compound having the structure set forth in Formula I: or a pharmaceutically acceptable salt thereof, wherein: A has the structure wherein each bond represented by a dashed and solid line in A represents a carbon-carbon single bond; a, b, c, and d are each carbon; e, f, g, and h are each carbon; X is nitrogen; X′ is C; L is absent; each n is 1; Y is nitrogen; W is nitrogen; R 1 is hydrogen; R 2 , R 3 , and R 4 are each independently selected from the group consisting of hydrogen, halogen, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 -alkoxyalkyl, optionally substituted C 1-6 alkylthio, perhaloalkyl, CN, COR 10 , CONHR 10 , NHCONHR 10 , SO 2 NHR 10 , SO 2 R 10 , OSO 2 R 10 , NO 2 , NHCOR 10 , or R 2 and R 3 , or R 3 and R 4 , taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety; R 5 is selected from the group consisting of halogen, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 -alkoxyalkyl, optionally substituted C 1-6 alkylthio, perhaloalkyl, CN, COR 10 , CONHR 10 , NHCONHR 10 , SO 2 NHR 10 , SO 2 R 10 , OSO 2 R 10 , NO 2 , NHCOR 10 , or R 4 and R 5 taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety; R 6 , R 7 , R 8 , and R 9 , are each independently selected from the group consisting of hydrogen, halogen, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 -alkoxyalkyl, optionally substituted C 1-6 alkylthio, perhaloalkyl, CN, COR 10 , CONHR 10 , NHCONHR 10 , SO 2 NHR 10 , SO 2 R 10 , OSO 2 R 10 , NO 2 , NHCOR 10 , or R 6 and R 7 , or R 7 and R 8 , or R 8 and R 9 taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety; Z is CH 2 ; R 10 is selected from the group consisting of hydrogen, optionally substituted C 1-6 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted aryl, optionally substituted arylalkyl, and perhaloalkyl; and each bond represented by a dashed and solid line in Formula I represents a carbon-carbon double bond.