Patent ID: 7544704

Claim:
An aryl-4-ethynyl-isoxazole derivative of formula I wherein R 1 , R 2 , and R 3 are each independently hydrogen, lower alkyl, halogen, lower alkoxy or amino; R 4 is lower alkyl; R 5 is optionally substituted aryl or heteroaryl, wherein the substituents are selected from the group consisting of lower alkyl, lower alkoxy, CF 3 , halogen, hydroxy, amino, —(CH 2 ) n —CN, —C(O)O-lower alkyl, —S(O) 2 NH 2 , —C(O)—NH—(CH 2 ) n -cycloalkyl, —C(O)—NH-heterocyclyl, —C(O)—NH-heteroaryl, and optionally substituted aryl, wherein the substituents are selected from halogen; n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof.