Patent ID: 7183273

Claim:
A method to treat HIV or rheumatoid arthritis in a subject which method comprises administering to a subject in need of such treatment an effective amount of a compound of formula I or pharmaceutically acceptable acid addition salts, and any stereoisomeric forms and mixtures of stereoisomeric forms thereof: and optionally one or more agent useful in the treatment HIV; wherein, W is a nitrogen atom and Y is void or, W is a carbon atom and Y=H; R 1 to R 7 may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C 1–6 alkyl, where R 1 and R 2 together may form ═O; R 8 is a substituted heterocyclic group or a substituted aromatic group Ar is an aromatic or heteroaromatic ring each optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups; n and n′ are independently, 0–2; X is a group of the formula: wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur or oxygen atom; wherein Ring B is an optionally substituted 5 to 7-membered ring; wherein Ring A or Ring B are bound to group W from any position through group V; wherein V is a chemical bond or V is a (CH 2 ) n ″group, (where n″=0–2) or V is a C═O group; and wherein Z is selected from the group consisting of: a hydrogen atom; an optionally substituted C 1–6 alkyl group; a C 0–6 alkyl group substituted with an optionally substituted aromatic or heterocyclic group; an optionally substituted C 0–6 alkylamino or C 3–7 cycloalkylamino group; and an optionally substituted carbonyl group or sulfonyl, thereby treating HIV or rheumatoid arthritis in said subject.