Patent ID: 7125888

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein a is 0 or 1; b is 0 or 1; m is 0, 1, or 2; R 1 is selected from: 1) aryl, 2) C 3 –C 5 cycloalkyl; 3) C 2 –C 3 alkenyl; 4) C 2 –C 3 alkynyl and 5) heteroaryl, said aryl, cycloalkyl and heteroaryl is optionally substituted with one or more substituents selected from R 3 ; R 2 is selected from: 1) aryl, 2) C 3 –C 8 cycloalkyl and 3) heterocyclyl, said aryl, cycloalkyl and heterocyclyl is optionally substituted with one or more substituents selected from R 4 ; R 3 is: 1) (C═O) a O b C 1 –C 3 alkyl, 2) CO 2 H, 3) halo, 4) CN, 5) OH, 6) O b C 1 –C 3 perfluoroalkyl, 7) O a (C═O) b NH 2 , 8) oxo, 9) CHO, or 10) (N═O)H 2 ; R 4 is: 1) (C═O) a O b C 1 –C 10 alkyl, 2) (C═O) a O b aryl, 3) C 2 –C 10 alkenyl, 4) C 2 –C 10 alkynyl, 5) (C═O) a O b heterocyclyl, 6) CO 2 H, 7) halo, 8) CN, 9) OH, 10) O b C 1 –C 6 perfluoroalkyl, 11) O a (C═O) b NR 6 R 7 , 12) oxo, 13) CHO, 14) (N═O)R 6 R 7 , or 15) (C═O) a O b C 3 –C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 5 ; R 5 is selected from: 1) (C═O) r O s (C 1 –C 10 )alkyl, wherein r and s are independently 0 or 1, 2) O r (C 1 –C 3 )perfluoroalkyl, wherein r is 0 or 1, 3) (C 0 –C 6 )alkylene-S(O) m R a , wherein m is 0, 1, or 2, 4) oxo, 5) OH, 6) halo, 7) CN, 8) (C 2 –C 10 )alkenyl, 9) (C 2 –C 10 )alkynyl, 10) (C 3 –C 6 )cycloalkyl, 11) (C 0 –C 6 )alkylene-aryl, 12) (C 0 –C 6 )alkylene-heterocyclyl, 13) (C 0 –C 6 )alkylene-N(R b ) 2 , 14) C(O)R a , 15) (C 0 –C 6 )alkylene-CO 2 R a , 16) C(O)H, and 17) (C 0 –C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 –C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 –C 6 alkyl, oxo, and N(R b ) 2 ; R 6 and R 7 are independently selected from: 1) H, 2) (C═O)O b C 1 –C 10 alkyl, 3) (C═O)O b C 3 –C 8 cycloalkyl, 4) (C═O)O b aryl, 5) (C═O)O b heterocyclyl, 6) C 1 –C 10 alkyl, 7) aryl, 8) C 2 –C 10 alkenyl, 9) C 2 –C 10 alkynyl, 10) heterocyclyl, 11) C 3 –C 8 cycloalkyl, 12) SO 2 R a , and 13) (C═O)NR b 2 , said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 5 , or R 6 and R 7 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 5–7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 5 ; R a is (C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkyl, aryl, or heterocyclyl; and R b is H, (C 1 –C 6 )alkyl, aryl, heterocyclyl, (C 3 –C 6 )cycloalkyl, (C═O)OC 1 –C 6 alkyl, (C═O)C 1 –C 6 alkyl or S(O) 2 R a .