Patent ID: 8268967

Claim:
An IFN-α conjugate comprising: an IFN-α peptide; and a glycosyl group attached to an asparagine, lysine, serine, or threonine residue of said IFN-α peptide, said glycosyl group comprising a modified sialyl residue having the formula: wherein R 2 is H, CH 2 OR 7 , COOR 7 or OR 7 wherein R 7 represents H, substituted or unsubstituted alkyl or substituted or unsubstituted heteroalkyl; R 3 and R 4 are members independently selected from H, substituted or unsubstituted alkyl, OR 8 , and NHC(O)R 9 wherein R 8 and R 9 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and sialic acid; L a is a linker selected from NHC(O), C(O)NH, and (CH 2 ) j C(O)NH(CH 2 ) h ,(CONH), wherein h and j are integers independently selected from 0 to 10; R 16 and R 17 are independently selected from a poly(ethylene glycol) moiety and a poly(amino acid) moiety; X 2 and X 4 are linkage fragments independently selected from S, SC(O)NH, HNC(O)S, SC(O)O, O, NH, NHC(O), (O)CNH, NHC(O)O, OC(O)NH, CH 2 S, CH 2 O, CH 2 CH 2 O, CH 2 CH 2 S, (CH 2 ) O O, (CH 2 ) O S, and (CH 2 ) O Y′-PEG wherein o is an integer from 1 to 50; Y′ is a member selected from S, NH, NHC(O), C(O)NH, NHC(O)O, OC(O)NH, and O; and X 5 is a member selected from H, CH 3 , and a poly(ethylene glycol) moiety.