Patent ID: 7288657

Claim:
A compound of formula I: wherein: a is 0 or an integer of from 1 to 5; each R 1 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 1a , —C(O)OR 1b , —SR 1c , —S(O)R 1d , —S(O) 2 R 1e , —NR 1f R 1g , —NR 1h S(O) 2 R 1i , and —NR 1j C(O)R 1k ; where each of R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 1g , R 1h , R 1i , R 1j , and R 1k is independently hydrogen, (1-4C)alkyl or phenyl(1-4C)alkyl; b is 0 or an integer of from 1 to 4; each R 2 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, —OR 2a , —C(O)OR 2b , —SR 2c , —S(O)R 2d , —S(O) 2 R 2e , —NR 2f R 2g , —NR 2h S(O) 2 R 2i , and —NR 2j C(O)R 2k ; where each of R 2a , R 2b , R 2c , R 2d , R 2e , R 2f , R 2g , R 2h , R 2i , R 2j , and R 2k is independently hydrogen, (1-4C)alkyl or phenyl(1-4C)alkyl; W represents O or NW a , where W a is hydrogen or (1-4C)alkyl; c is 0 or an integer from 1 to 5; each R 3 independently represents (1-4C)alkyl or two R 3 groups are joined to form (1-3C)alkylene, (2-3C)alkenylene or oxiran-2,3-diyl; m is 0 or 1; R 4 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; s is 0, 1 or 2; Ar 1 represents a phenylene group or a (3-5C)heteroarylene group containing 1 or 2 heteroatoms independently selected from oxygen, nitrogen or sulfur; wherein the phenylene or heteroarylene group is substituted with (R 5 ) q where q is 0 or an integer from 1 to 4 and each R 5 is independently selected from halo, hydroxy, (1-4C)alkyl or (1-4C)alkoxy; t is 0, 1 or 2; n is 0 or an integer from 1 to 3; d is 0 or an integer from 1 to 4; each R 6 independently represents fluoro or (1-4C)alkyl; p is 0 or 1; and R 7 and R 8 are independently hydrogen or (1-4C)alkyl; wherein each alkyl and alkoxy group in R 1 , R 1a-1k , R 2 , R 2a-2k , R 3 , R 5 , R 6 , R 7 , and R 8 is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.