Patent ID: 8202909

Claim:
A method for treating a central nervous system disorder in a mammalian subject, which comprises administering an effective amount of an 11-deoxy-prostaglandin compound represented by the formula (III): wherein L is hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, lower alkanoyloxy or oxo, wherein the five-membered ring may optionally have at least one double bond; A is —CH 3 , —CH 2 OH, —COCH 2 OH, —COOH or a functional derivative thereof; B is single bond, —CH 2 —CH 2 —, —CH═CH—, —C≡C—, —CH 2 —CH 2 —CH 2 , —CH═CH—CH 2 —, —CH 2 —CH═CH—, —C≡C—CH 2 —or —CH 2 —C≡C—; C═Z is C═O; X 1 and X 2 are hydrogen, lower alkyl, or halogen; R 1 is a saturated or unsaturated bivalent lower or medium aliphatic hydrocarbon, which is unsubstituted or substituted with halogen, alkyl, hydroxy, oxo, aryl or heterocyclic group, and at least one of carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; and R 2 is a single bond or lower alkylene; and R 3 is lower alkyl, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic-oxy group, and at least one of carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; to a subject in need thereof.