Patent ID: 7642289

Claim:
Nitrooxyderivatives or salts thereof of formula (I) R—NR 1c —(K) k0 —(B) b0 —(C) c0 —NO 2 (I) wherein c0 is 1 b0 is 0; k0 is 0; R 1c is H C=bivalent radical of formula —T c —Y wherein T c =(CO); and Y is an alkylenoxy group —R′O— in which R′ is straight or branched C 1 -C 20 alkyl, a cycloalkylene with from 5 to 7 carbon atoms, or wherein n3 is an integer from 0 to 5 and n3′ is an integer from 1 to 3; R is a radical of an analgesic drug of formula (II): wherein: W is a carbon atom; m is 1; R 0 =—(CH 2 ) n —COOR y , wherein R y =H, C 1 -C 10 -alkyl, phenyl, or benzyl; n is an integer of from 0 to 2; R 1 =H R 2 is selected from the following groups: phenyl, optionally substituted with a halogen atom or with a group selected from —OCH 3 , —CF 3 , nitro or dihydroxy-substituted benzyl; amidino group: H 2 N(C═NH)—; a radical of formula (IIA), wherein optionally an ethylenic unsaturation may be present between the carbon atoms in position 1 and 2, or 3 and 4 or 4 and 5: wherein: p, p 1 , p 2 are integers, same or different, and are 0 or 1; p 3 in an integer of from 0 to 10; R 4 is hydrogen, straight or branched C 1 -C 6 -alkyl, free valence; R 5 is: hydrogen, straight or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, or OR A , wherein R A is: straight or branched C 1 -C 6 -alkyl, optionally substituted with one or more halogen atoms, or phenyl optionally substituted with a halogen atom or with one of the following groups: —OCH 3 , —CF 3 , nitro; R 6 , R 6A , R 7 , R 8 , the same or different, are H, methyl or free valence, with the proviso that when an ethylenic unsaturation is present between C 1 and C 2 in radical of formula (IIA), R 4 and R 5 are free valences able to form the double bond between C 1 and C 2 ; if the unsaturation is between C 3 and C 4 , R 6 and R 7 are free valence able to form the double bond between C 3 and C 4 ; is the unsaturation is between C 4 and C 5 , R 7 and R 8 are free valence able to form the double bond between C 4 and C 5 ; Q is H, OH, OR B , R B being benzyl, straight or branched C 1 -C 6 -alkyl, optionally substituted with one or more halogen atoms, preferably F, phenyl optionally substituted with a halogen atom or with one of the following groups: —OCH 3 , —CF 3 , nitro; or Q is —C 3 -C 6 -cycloalkyl, guanidino (H 2 NC(═NH)NH—), or thioguanidino (H 2 NC(═S)NH—), in formula (II) R 2 with R 1 and with W═C form together a C 4 -C 10 saturated or unsaturated ring.