Patent ID: 8900815

Claim:
A method for evaluating whether coronary artery disease has progressed in a patient previously diagnosed as having said disease and stable angina, wherein said method comprises: (a) obtaining a biological sample of coronary sinus blood from said patient at a first time point and a second time point; (b) detecting the level of platelet-derived microparticles (PDMPs) or a fragment thereof, in the first time point sample and the second time point sample with an antibody to PDMPs or a fragment thereof; wherein an increase in a level of the PDMPs in the second time point sample in comparison to a level in the first time point sample is indicative of progression of coronary artery disease; and wherein the level of PDMPs or a fragment thereof of 10.2±5.7 to 30.4±14.6 U/ml in said coronary sinus blood is indicative of progression of coronary artery disease.