Patent ID: 8716253

Claim:
A method for modulating the immunostimulatory effect of an immunostimulatory oligonucleotide compound having an immunostimulatory dinucleotide selected from the group consisting of C*pG, CpG*, and C*pG*, wherein C is 2′-deoxycytidine, C* is selected from 5-hydroxycytosine, 5-hydroxymethylcytosine, N4-alkylcytosine, and 4-thiouracil, G is 2′-deoxyguanosine and G* is selected from 7-deazaguanosine and 6-thioguanosine, comprising introducing a 1′,2′-dideoxyribose, C3-linker, Spacer 9, Spacer 18, β-L-deoxynucleoside, or 2′-O-propargyl-ribonucleoside into the 5′ and/or 3′ side of the immunostimulatory dinucleotide.