Patent ID: 7381737

Claim:
A process for preparing a spiro-hydantoin compound (II) of formula comprising: contacting alkene compound (I) of formula: with: i) a methylene precursor compound and ii) glycine or glycine ester, in presence of polar solvent to afford: said spiro-hydantoin compound (II) or a pharmaceutically-acceptable salt, hydrate, solvate, or prodrug thereof; wherein: L and K are independently O or S; Z is N or CR 4b ; Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; G is a bond, —O—, —S—, —NR 1 , C 1-3 alkylene, C 1-3 substituted alkylene, bivalent alkoxy, thioalkyl, aminoalkyl, sulfonyl, sulfonamidyl, acyl, or alkoxycarbonyl; R 1 is hydrogen, alkyl, or substituted alkyl; R 2 is hydrogen, alkyl, substituted alkyl, OR 12 , NR 12 R 13 , C(═O)R 12 , —CO 2 R 12 , —C(═O)NR 12 R 13 , —NR 12 C(═O)R 13 , —NR 12 C(═O)OR 13 , —S(O) p R 13a , —NR 12 SO 2 R 13a , —SO 2 NR 12 R 13 , cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; R 4a , R 4b , and R 4c are independently hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, nitro, cyano, —SR 14 , —OR 14 , —NR 14 R 15 , —NR 14 C(═O)R 15 , —CO 2 R 14 , —C(═O)R 14 , —C(═O)NR 14 R 15 , aryl, substituted aryl, heterocyclo, substituted heterocyclo, cycloalkyl, substituted cycloalkyl heteroaryl, and/or substituted heteroaryl; R 12 , R 13 , R 14 , and R 15 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, and/or substituted heterocyclo; or (ii) R 12 is taken together with R 13 , and/or R 14 is taken together with R 15 to form a heteroaryl, substituted heteroaryl, heterocyclo, or substituted heterocyclo ring; R 13a is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclo, or substituted heterocyclo; and p is 1 or 2.