Patent ID: 7736852

Claim:
A method of determining a predisposition or susceptibility of a human subject to bipolar disorder comprising a) determining a genotype of said subject for: i) a polymorphism in position −584 of the vesicular monamine transporter 1 (VMAT1) gene ii) a polymorphism in codon 4 of the VMAT1 gene iii) a polymorphism in codon 98 of the VMAT1 gene iv) a polymorphism in codon 136 of the VMAT1 gene v) a polymorphism at position 26 of SEQ ID NO: 9 vi) polymorphism at position 26 of SEQ ID NO: 8 b) detecting the G-Thr-Thr-Ile-A-G combination of alleles of said polymorphisms and c) correlating the presence of the combination of alleles with predisposition or susceptibility to bipolar disorder.