Patent ID: 7666865

Claim:
A method to treat pain in a subject which method comprises administering to a subject in need of such treatment a compound of the formula wherein m is 0, 1 or 2; wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C; Y is H, OH, NH 2 , or an organic moiety of 1-20C, optionally additionally containing 1-8 heteroatoms selected from the group consisting of N, P, O, S and halo; each l 1 and l 2 is independently 0-5; l 3 is 0 or 1; each of R 1 , R 2 and R 3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or each of R 1 and R 2 may independently be halo, COOR, CONR 2 , CF 3 , CN or NO 2 , wherein R is H or lower alkyl (1-4C) or alkyl (1-6C); n is 0 or 1; X is a linker; with the proviso that Y is not a tropolone, a coumarin, or an antioxidant containing an aromatic group and with the further proviso that if l 3 is 0, and either l 1 and l 2 is 0 or 1 and if R 1 and/or R 2 represent F in the para position, Z cannot be N or C.