Patent ID: 8198402

Claim:
An isolated or purified polypeptide, a functional variant thereof, a fatty acid derivative of the polypeptide, or a fatty acid derivative of the functional variant, wherein the polypeptide consists of the amino acid sequence of SEQ ID NO: 3 or a functional fragment thereof, and the functional fragment consists of at least 7 contiguous amino acids of SEQ ID NO: 3, the polypeptide is optionally amidated, and the amino acid at position 1 of the polypeptide is optionally acetylated, wherein the functional variant consists of i) the reversed amino acid sequence of SEQ ID NO: 3 (all D-amino acids), ii) the reversed amino acid sequence of the functional fragment of SEQ ID NO: 3 (all D-amino acids) and the functional fragment consists of at least 7 contiguous amino acids of SEQ ID NO: 3, iii) the amino acid sequence of any one of SEQ ID NOs: 49-52, and 68 (all D-amino acids), and SEQ ID NO: 80, or iv) an amino acid sequence which has at least 90% sequence identity with SEQ ID NO: 3, or the functional fragment of SEQ ID NO: 3 and the functional fragment consists of at least 7 contiguous amino acids of SEQ ID NO: 3, wherein the functional variant is optionally amidated and the amino acid at position 1 of the functional variant is optionally acetylated, and wherein the polypeptide, the functional variant, and the fatty acid derivative inhibit proliferation of a tumor cell.