Patent ID: 8552219

Claim:
A process for the preparation of a 1-phenyl-3-dimethylaminopropane derivative of formula I: an isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a solvate thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof; said method comprising: a) converting 1-(3-hydroxy-phenyl)-propan-1-one of formula II, into a compound of general formula III, wherein R 1 is selected from —SO 2 R 2 ; R 2 is selected from hydrogen, straight chain or branched alkyl, aryl, aralkyl, alkaryl, heteroalkyl, heteroaryl, wherein R 2 is is substituted or unsubstituted; b) reacting the compound of formula III with a suitable organometallic reagent to give a hydroxyl compound of formula IV, wherein R 1 is as defined above; c) optionally, reacting the hydroxyl compound of formula IV with a suitable acid to form a corresponding salt of the hydroxyl compound of formula IV; d) dehydrating the hydroxyl compound of formula IV or the corresponding salt thereof using a suitable dehydrating agent to give an alkene compound of formula V, wherein R 1 is as defined above; e) hydrogenating the alkene compound of formula V using a suitable reagent to give a compound of formula VI, wherein R 1 is as defined above; and f) deprotecting the compound of formula VI with a suitable deprotecting reagent to give the compound of formula I or a pharmaceutically acceptable salt thereof.