Patent ID: 7709007

Claim:
An infectious recombinant respiratory syncytial virus (RSV) particle comprising a RSV genome or antigenome, a major nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large polymerase protein (L), and an M2ORF1 RNA polymerase elongation factor, wherein a modification is introduced within the genome or antigenome comprising a deletion, insertion, substitution, rearrangement, or point mutation of a gene or genome segment, or nucleotide modification of a cis-acting regulatory sequence or by introduction of a translation termination codon, wherein at least one of a SH, NS 1, NS2, or G gene is deleted in whole or in part, or the expression of at least one of a SH, NS1, NS2 or G gene is ablated, said recombinant RSV being attenuated by 10- to 1000-fold compared to wild type RSV in the respiratory tract of a primate host.