Patent ID: 8497269

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein A 4 is CR 5 or N; L is NR 4 or S; R 1 is C 1-10 -alkyl, —OC 1-10 -alkyl, —NHC 1-10 alkyl, —N(C 1-10 -alkyl) 2 , C 2-10 -alkenyl, C 2-10 -alkynyl or C 3-10 -cycloalkyl, each of the C 1-10 -alkyl, —OC 1-10 -alkyl, —NHC 1-10 -alkyl, —N(C 1-10 -alkyl) 2 , C 2-10 -alkenyl, C 2-10 -alkynl, C 3-10 -cycloalkyl and C 4-10 -cycloalkenyl, each of which is optionally comprising 1-4 heteroatoms selected from N, O and S and optionally substituted with 1-5 substituents of R 6 ; or R 1 is a 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein said ring system is optionally substituted independently with 1-5 substituents of R 6 ; R 2 is H, F, Cl, Br, CF 3 , NO 2 , CN, C 1-3 -alkyl, C 1-3 -alkoxyl, C 1-3 -thioalkyl, C 1-3 -aminoalkyl; each R 3 , independently, is H, F, Cl, Br, CF 3 , NO 2 , CN, OH, C 1-3 -alkyl, C 1-3 -alkoxyl, C 1-3 -thioalkyl, C 1-3 -aminoalkyl or acetyl; R 4 is H or C 1-3 -alkyl; each R 5 , independently, is H, F, Br, Cl, I, haloalkyl, NO 2 , CN, C 1-6 -alkyl, C 1-6 -alkoxyl, C 1-6 -thioalykl, C 1-6 -aminoalkyl or di-C 1-6 -aminoalkyl; each R 6 , independently, is halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, oxo, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl, —S(O) 2 C 1-10 -alkyl, —C(O)NHC 1-10 -alkyl, —C(O)NH 2 , a saturated or partially or fully unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S or —C(O)- saturated or partially or fully unsaturated 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and each ring of said ring system and —C(O)-ring system is optionally substituted independently with 1-3 substituents of halo, haloalkyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, methylamine, dimethylamine, ethylamine, diethylamine, propylamine, isopropylamine, dipropylamine, diisopropylamine, benzyl or phenyl; and m is 0, 1, 2, 3 or 4.