Patent ID: 8093247

Claim:
A method for treating a CCR2-mediated condition or disease comprising administering to a subject an effective amount of a compound of the formula (XCVI), or a salt thereof: where X b is selected from the group consisting of halogen and —CH 3 , and X c is selected from the group consisting of halogen, —CN, —CH 3 , —OCH 3 , —OCF 3 and —CF 3 ; Y b and each occurrence of Y a are selected from the group consisting of hydrogen, halogen and unsubstituted C 1-8 alkyl; and L is —C(O)—; Z 1 is of the formula (CVII) where A is selected from the group consisting of —CH— and —N—; wherein one or two of A are —N—; E is —CH; G is —NR 47 —; where R 47 is hydrogen or unsubstituted C 1-8 alkyl; wherein the CCR2-mediated condition or disease is selected from: atherosclerosis, restenosis, multiple sclerosis, inflammatory bowel disease, renal fibrosis, diabetes, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and idiopathic pneumonia syndrome, and neuropathic pain.