Patent ID: 7341730

Claim:
An isolated polypeptide consisting of the sequence R-XDVCQD-R′ (SEQ ID NO:45), wherein the polypeptide has anti-angiogenic activity, and wherein: R is selected from the group consisting of Aa 1 -Aa 2 -Aa 3 -Aa 4 -Aa 5 , Aa 2 -Aa 3 -Aa 4 -Aa 5 , Aa 3 -Aa 4 -Aa 5 , Aa 4 -Aa 5 and Aa 5 , or is absent, wherein: Aa 1 is glutamine; Aa 2 is proline; Aa 3 is lysine; Aa 4 is aspartic acid; and Aa 5 is asparagine; and, X is selected from the group consisting of glycine, alanine, serine and threonine, or is absent when R is absent; and, R′ is from 0 to about 59 contiguous amino acids.