Patent ID: 7875618

Claim:
A compound of formula (IIa) wherein R 1 is: a saturated, monounsaturated or polyunsaturated carbocyclic ring system with 3 to 8 ring atoms or a heterocyclic ring system with 5 to 15 ring atoms containing at least one heteroatom selected from N,N-oxide, O, and S, wherein each ring system is optionally mono- or polysubstituted with halo, amino, C 1-3 alkylamino, di-C 1-3 alkylamino, nitro, C 1-3 alkyl, O—C 1-3 alkyl, CF 3 , OCF 3 , COOH, CONH 2 , CONHR 7 , CON(R 7 ) 2 , or a cyclic radical; wherein R 7 is in each case independently C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, phenyl, or a heterocyclic ring system with 5 to 6 ring atoms containing at least one heteroatom selected from N,N-oxide, O, and S, each optionally mono- or polysubstituted with halo, OH, O—C 1-3 alkyl, or a cyclic radical, or two R 7 in group CON(R 7 ) 2 , together with the nitrogen atom to which they are attached, form a saturated or unsaturated five-, six- or seven-membered ring which contains up to 3 heteroatoms selected from N,N-oxide, S, and O, optionally mono- or polysubstituted with halo, C 1-3 alkyl, O—C 1-3 alkyl, or aryl-C 1-5 alkyl, wherein aryl is phenyl, optionally mono- or polysubstituted with halo, nitro, C 1-3 alkyl, O—C 1-3 alkyl, or a cyclic radical; wherein R 2 is C 1-6 alkyl; R 3 is C 1-5 alkyl; wherein R 4 and R 5 are in each case independently selected from: H, halo, a cyclic radical, R 9 , OH or OR 9 , NH(C═O)—C 1-3 alkyl optionally mono- or polysubstituted with halo, OH, O—C 1-3 alkyl, or a cyclic radical, NH 2 , NHR 9 , and NR 9 R 10 ; and wherein R 9 and R 10 are independently selected from a cyclic radical, C 1-6 alkyl or C 3-6 cyclo(hetero)alkyl, optionally mono- or polysubstituted with halo, OH, O—C 1-3 alkyl, or a cyclic radical, aryl-C 1-5 alkyl wherein aryl is phenyl, optionally mono- or polysubstituted with halo, amino, C 1-3 alkylamino, di-C 1-3 alkylamino, nitro, C 1-3 alkyl, OH, O—C 1-3 alkyl, NH(CO)NHCH 3 , or a cyclic radical, or R 9 and R 10 , together with the nitrogen atom to which they are attached, form a saturated or unsaturated five-, six- or seven-membered ring which contains up to 3 heteroatoms selected from N,N-oxide, S, and O, optionally mono- or polysubstituted with halo, amino, C 1-3 alkylamino, di-C 1-3 alkylamino, C 1-3 alkyl, O—C 1-3 alkyl, or aryl-C 1-5 alkyl, wherein aryl is phenyl, optionally mono- or polysubstituted with halo, amino, C 1-3 alkylamino, di-C 1-3 alkylamino, nitro, C 1-3 alkyl, O—C 1-3 alkyl, or a cyclic radical; or a pharmaceutically acceptable salt thereof.