Patent ID: 8877890

Claim:
A cyclic peptide of the formula: Z-Xaa 1 -Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Xaa 6 -Xaa 7 -Y or a pharmaceutically acceptable salt thereof, wherein: Z is H or an N-terminal group; Xaa 1 is an amino acid with a side chain including a linear or branched alkyl, cycloalkyl, cycloheteroalkyl, aryl or heteroaryl; Xaa 2 and Xaa 6 are L- or D-isomer amino acids wherein the side chains thereof comprise a cyclic bridge; Xaa 3 is L- or D-Pro, optionally substituted with hydroxyl, halogen, sulfonamide, alkyl, —O-alkyl, aryl, alkyl-aryl, alkyl-O-aryl, alkyl-O-alkyl-aryl, or —O-aryl, or Xaa 3 is an L- or D-isomer of an amino acid with a side chain including at least one primary amine, secondary amine, alkyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, ether, sulfide, or carboxyl; Xaa 4 is an L- or D-isomer amino acid with a side chain including phenyl, naphthyl or pyridyl, optionally substituted with one or more substituents independently selected from halo, (C 1 -C 10 )alkyl-halo, (C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkylthio, aryl, aryloxy, nitro, nitrile, sulfonamide, amino, monosubstituted amino, disubstituted amino, hydroxy, carboxy, and alkoxy-carbonyl; Xaa 5 is L- or D-Pro or Xaa 5 is an L- or D-isomer amino acid with a side chain including at least one primary amine, secondary amine, guanidine, urea, alkyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, or ether; Xaa 7 is optionally present, and if present is from one to three L- or D-isomer amino acid residues; and Y is a C-terminal group.