Patent ID: 8242134

Claim:
A compound according to formula I wherein A represents N, CH or CR 1 ; each R 1 independently represents hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(O)—C 1-6 alkyl, —C(O)—C 2-6 alkenyl, —C(O)—C 2-6 alkynyl, —C(O)—O—C 2-6 alkenyl, —C(O)—O—C 2-6 alkynyl or phenyl, wherein said phenyl, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl is optionally substituted with one or more substituents selected from halogen, hydroxyl, haloC 1-6 alkyl, nitro, C 1-6 alkoxy, and NR 2 R 3 ; X represents hydrogen, C 1-6 alkyl optionally substituted with F, or —CR a R b —X′, wherein X′ represents a monocyclic saturated moiety having 5-6 ring atoms one of which is N and wherein one or two additional ring atom may be a hetero atom selected from N, O and S, which monocyclic ring may be substituted with one or more substituent W, wherein W is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl or (═O); R a and R b each individually represent hydrogen, —CH 3 or halogen; Q represents a bond, —CH 2 —, —NH—, or —O—; Y represents C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein said alkyl, alkenyl or alkynyl may be substituted with one or more substituents P, wherein P is selected from halogen, hydroxy, C 1-6 alkoxy, cyano, —S—C 1-6 alkyl, and a monocyclic saturated moiety having 5-6 ring atoms one ring atom of which may be N and the rest is C; or Y may represent a monocyclic saturated moiety having 4-6 ring atoms, wherein one of said ring atoms may be selected from N and O, the rest being C, and which monocyclic saturated moiety may be substituted with one or more substituents Z, wherein Z is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (═O), C(O)H, —C(O)—C 1-6 alkyl, halogen, C 1-6 alkoxy, C 1-6 hydroxyalkyl and hydroxy; wherein each of R 2 and R 3 independently represents hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, hydroxyC 1-6 alkyl, or haloC 1-6 alkyl; each of R 4 -R 8 and R 9 -R 12 independently represents hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halogen, NR 2 R 3 , hydroxy, cyano, nitro, C 1-6 alkoxy, haloC 1-6 alkyl or hydroxyC 1-6 alkyl; provided said compound is different from 2-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid (1-phenyl-ethyl)-amide; or a pharmaceutically acceptable salt thereof.