Patent ID: 7960182

Claim:
A method for binding an analyte consisting essentially of Factor VIII, von Willebrand's Factor or a protein that is an analogue of either, wherein the analogue is a functional fragment of Factor VIII or von Willebrand's Factor, a structural analogue having one or more of the same binding sites of Factor VIII or von Willebrand's Factor, or a fusion protein comprising Factor VIII, von Willebrand's Factor, a functional fragment, or a structural analogue thereof, wherein said method comprises providing an affinity adsorbent material comprising a support matrix having covalently attached to its surface in sufficient quantity to act as an effective adsorbent material a compound having the following structure: wherein each X is N; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR 2 ; Z is O, S or N—R 3 ; R 2 and R 3 are each H or C 1-6 alkyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; W is an optionally substituted hydrocarbon chain containing up to 4 carbon atoms in the hydrocarbon chain; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH 2 ) 3-4 —NH 2 ; and R 7 is a tertiary amine group bearing a positive charge at neutral pH; and contacting a sample containing the analyte so that the analyte binds to the affinity adsorbent material.