Patent ID: 7488727

Claim:
A compound of formula I: or a pharmaceutically acceptable derivative thereof, wherein: R 1 is selected from R, halogen, CN, NO 2 , or TR; T is an optionally substituted C 1 -C 4 alkylidene chain wherein up to two methylene units of T are optionally and independently replaced by O, N(R), C(O), S, SO, or SO 2 ; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, wherein: two R bound to the same nitrogen atom are optionally taken together with the nitrogen to form a 3-7 membered saturated, partially unsaturated, or fully unsaturated ring having 0-2 heteroatoms, in addition to the nitrogen bound thereto, independently selected from nitrogen, oxygen, or sulfur; Ar 1 is an optionally substituted ring selected from: (a) a 3-8 membered monocyclic saturated or partially unsaturated ring; or 8-10 membered bicyclic saturated or partially unsaturated ring, or a naphthyl ring; (b) a 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (c) a 5-6 membered monocyclic or 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: Ar 1 is optionally substituted by one to four substituents selected from the group consisting of: (a) one group selected from QR, Ar 2 , or QAr 2 ; and (b) up to four R 2 groups; each Q is independently selected from a valence bond or an optionally substituted C 1-6 alkylidene chain, wherein: one or two non-adjacent methylene units of Q are optionally and independently replaced by —O—, —S—, —NR—, —C(O)—, —CO 2 —, —C(O)NR—, —OC(O)NR—, —C(O)C(O)—, —NRC(O)—, NRCO 2 —, —NRC(O)NR—, —S(O)—, —SO 2 —, —NRSO 2 —, —SO 2 NR—, or —NRSO 2 NR—; each Ar 2 is an optionally substituted ring independently selected from: (a) a 3-8 membered monocyclic or 8-10 membered bicyclic saturated, partially unsaturated, or aryl ring; (b) a 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (c) a 5-6 membered monocyclic or 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: Ar 2 is optionally substituted by one to four R 2 groups; and each R 2 is independently selected from R, halogen, NO 2 , CN, OR, SR, N(R) 2 , NRCOR, NRCON(R) 2 , NRCO 2 R, C(O)R, CO 2 R, CON(R) 2 , OC(O)N(R) 2 , SOR, SO 2 R, SO 2 N(R) 2 , NRSO 2 R, NRSO 2 N(R) 2 , C(O)C(O)R, or C(O)CH 2 C(O)R; wherein: two R 2 on adjacent positions on Ar 1 or Ar 2 are optionally taken together to form a saturated, partially unsaturated, or fully unsaturated 4-6 membered ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur.