Patent ID: 8921537

Claim:
A polynucleotide encoding an anti-vascular endothelial growth factor (VEGF) antibody, wherein the antibody comprises six HVRs: (i) an HVR-L1 comprising the amino acid sequence of X 1 X 2 R X 3 SL wherein the HVR-L1 comprises 1, 2 or 3 substitutions in any combination of the following positions: X 1 is G or A; X 2 is V or I; and/or X 3 is T or R; (ii) an HVR-L2 comprising the amino acid sequence of DASSLA (SEQ ID NO:6); (iii) an HVR-L3 comprising the amino acid sequence of SYKSPL (SEQ ID NO:7); (iv) an HVR-H1 comprising the amino acid sequence of SISGSWIF (SEQ ID NO:1); (v) an HVR-H2 comprising the amino acid sequence of GAIWPFGGYTH (SEQ ID NO:2); and (vi) an HVR-H3 comprising the amino acid sequence of RWGHSTSPWAMDY (SEQ ID NO:3).