Patent ID: 7273845

Claim:
A method of preparing a vancomycin-polymer conjugate wherein the polymer is conjugated to the suger amino group of a vancomycin, comprising: reacting a vancomycin compound of the formula: wherein R 11 and R 12 are independently selected from the group consisting of hydrogen, C 1-6 alkyl[s], C 3-12 branched alkyl[s], C 3-8 cycloalkyl[s], C 1-6 substituted alkyl[s], C 3-8 substituted cycloalkyl[s], aryl[s], substituted aryl[s], aralkyl[s], C 1-6 heteroalkyl[s], substituted C 1-6 heteroalkyl[s], C 1-6 alkoxyalkyl, phenoxyalkyl and C 1-6 heteroalkoxy[s]; R 13 is OH, NH-aryl, NH-aralkyl, or NH—C 1-12 alkyl; and w is 1 or 2; in the presence of at least about a ten-fold molar excess of triethylamine and a sufficient amount of dimethylformamide with a polyalkylene oxide residue containing at least one leaving group that reacts with the sugar amino group NR 11 H of said vancomycin compound.