Patent ID: 7682351

Claim:
A method for infusing insulin intravenously to a subject to improve impaired hepatic glucose processing comprising the steps of: a. determining a baseline circulating glucose level of the subject and obtaining a subsequent circulating glucose level at least every 30 minutes, b. having the subject ingest a carbohydrate containing meal to cause a rise in circulating glucose levels, c. administering a series of insulin pulses until the rise in circulating glucose levels falls a threshold of at least 50 to 100 milligram per deciliter within two hours of administering an initial pulse of insulin; the series of insulin pulses having an amount of insulin in each pulse, an interval of time between pulses and a total time to deliver the series of pulses; d. repeating steps a, b and c at least one more time during a treatment day when said threshold is met; e. changing the amount of ingested carbohydrate of step b or changing the amount of insulin in each pulse, the interval of time between pulses or the total time to deliver the series of pulses of step c when said threshold is not met and repeating steps a, b, c and d; the threshold of 50 milligrams per deciliter fall in circulating glucose levels being an indicator that the amount of ingested carbohydrate, the amount of insulin in each pulse, the interval of time between pulses, and the total time to deliver the series of pulses is sufficient to achieve an improvement in hepatic glucose processing, wherein said method measures in real time when the subject has actually activated hepatic glucose processing allowing positive confirmation of successful patient response.