Patent ID: 8399502

Claim:
A method for treating a bacterial infection in a mammalian individual in need thereof, comprising administering to the individual a therapeutically effective amount of a compound having the structure of formula (I) wherein: R 1 , R 3 , R 4 , R 5 , R 7 , R 8 , and R 9 , are substituents independently selected from the group consisting of hydrogen, C 1 -C 24 alkyl, C 2 -C 24 alkenyl, C 2 -C 24 alkynyl, C 5 -C 20 aryl, C 6 -C 24 alkaryl, C 6 -C 24 aralkyl, halo, hydroxyl, sulfhydryl, C 1 -C 24 alkoxy, C 2 -C 24 alkenyloxy, C 2 -C 24 alkynyloxy, C 5 -C 20 aryloxy, acyloxy, C 2 -C 24 alkoxycarbonyl, C 6 -C 20 aryloxycarbonyl, C 2 -C 24 alkylcarbonyl, C 6 -C 20 arylcarbonyl, halocarbonyl, C 2 -C 24 alkylcarbonato, C 6 -C 20 arylcarbonato, carboxy, carboxylato, carbamoyl, mono-(C 1 -C 24 alkyl)-substituted carbamoyl, di-(C 1 -C 24 alkyl)-substituted carbamoyl, mono-substituted arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, dihydroxyboryl, di-(C 1 -C 24 )-alkoxyboryl, isothiocyanato, azido, formyl, thioformyl, amino, mono- and di-(C 1 -C 24 alkyl)-substituted amino, mono- and di-(C 5 -C 20 aryl)-substituted amino, C 2 -C 24 alkylamido, C 6 -C 20 arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C 1 -C 24 alkylsulfanyl, arylsulfanyl, C 1 -C 24 alkylsulfinyl, C 5 -C 20 arylsulfinyl, C 1 -C 24 alkylsulfonyl, C 5 -C 20 arylsulfonyl, phosphono, phosphonato, phosphinato, phospho, phosphino, and combinations thereof; R 2 and R 6 are independently halo; R 10 is selected from unsubstituted C 1 -C 24 alkyl, substituted C 1 -C 24 alkyl, heteroatom containing C 1 -C 24 alkyl, unsubstituted C 2 -C 24 alkenyl, substituted C 2 -C 24 alkenyl, heteroatom containing C 2 -C 24 alkenyl, unsubstituted C 2 -C 24 alkynyl, substituted C 2 -C 24 alkynyl, heteroatom containing C 2 -C 24 alkynyl, unsubstituted C 1 -C 24 alkoxy, substituted C 1 -C 24 alkoxy, and heteroatom containing C 1 -C 24 alkoxy; and R 11 and R 12 are independently selected from the group consisting of hydrogen, formyl, C 1 -C 24 alkyl, C 6 -C 24 aralkyl, C 2 -C 24 alkoxycarbonyl, amino-substituted C 1 -C 24 alkyl, (C 1 -C 24 alkylamino)-substituted C 1 -C 24 alkyl, di-(C 1 -C 24 alkyl)amino-substituted C 1 -C 24 alkyl, and nitrogen protecting groups, or a pharmaceutically acceptable salt thereof.