Patent ID: 8669369

Claim:
A method for preparing a compound, N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(4-(2-(N-(methyl-d 3 )aminoformyl)-4-pyridyloxy)phenyl)urea: comprising a step selected from the group consisting of (a), (b) and (c): (a) in an inert solvent and in the presence of a base, reacting compound III with compound V to form the compound: wherein X is Cl, Br, or I; and the compound III is prepared using a method comprising: (i) reacting p-methoxy-aniline (X) with 4-chloro-3-trifluoromethyl-aniline (II) or 4-chloro-3-trifluoromethyl phenyl isocyanate (VIII) to form compound XI: and (ii) in an acidic or basic condition, demethylating compound XI to form compound III; (b) in an inert solvent, reacting compound IX with CD 3 NH 2 or CD 3 NH 2 .HCl to form the compound: wherein R is a straight-chain or branched chain C1-C8 alkyl, or aryl; and (c) in an inert solvent, reacting 4-chloro-3-trifluoromethyl phenyl isocyanate (VIII) with compound 5 to form the compound, wherein the inert solvent is the mixed solvent of dimethylsulfoxide and dichloromethane: