Patent ID: 7693698

Claim:
A method for identifying a candidate agent that interacts with a LINGO-1 polypeptide, comprising: (a) generating a three-dimensional model on a computer wherein the three-dimensional model has the x-ray structural coordinates of the LINGO-1 polypeptide according to Table 2 ± a root mean square deviation from the backbone atoms that is not more than 1.5 Å; (b) identifying the amino acid residues forming the active site of the LINGO-1 polypeptide from the three-dimensional model in step (a) in order to generate a three-dimensional representation of the active site of the LINGO-1 polypeptide, wherein the active site of the LINGO-1 polypeptide comprises amino acids Asp13, Arg20, Arg22, Arg43, Glu60, Glu62, Leu94, Leu120, Met123, His176, Tyr142, His145, His 185, His209, His233, Ala238, Trp346, Arg347, Asn349, Asn351, Arg352, Gln353, Phe396, Arg408, Leu420, Leu426, Phe438, Asp440, Arg446, Tyr447 and Ile459 as set forth in SEQ ID NO: 1 and has the x-ray structural coordinates as shown in Table 2 ± a root mean square deviation from the backbone atoms of said amino acids of not more than 1.5 Å; (c) employing said three-dimensional representation from step (b) to identify a candidate agent that interacts with the active site of the LINGO-1 polypeptide; and (d) obtaining the candidate agent.