Patent ID: 7696320

Claim:
A ligand that has binding specificity for vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR), comprising at least one immunoglobulin single variable domain that has a binding site with binding specificity for VEGF, wherein each said immunoglobulin single variable domain with binding specificity for VEGF comprises an amino acid sequence that has at least 95% amino acid sequence identity with the amino acid sequence of a dAb selected from the group consisting of TAR15-6 (SEQ ID NO:117), TAR15-8 (SEQ ID NO:119), and TAR15-26 (SEQ ID NO:123), and at least one immunoglobulin single variable domain that has a binding site with binding specificity for EGFR, wherein each said immunoglobulin single variable domain with binding specificity for EGFR comprises an amino acid sequence that has at least 95% amino acid sequence identity with the amino acid sequence of a dAb DOM16-39 (SEQ ID NO:345).