Patent ID: 7977345

Claim:
A compound of formula IVc: wherein: J 1 is ═CH—; J 2 is ═C(R 1 )—; J 3 is ═N—; J 4 is ═N—; J 5 is C—H or C—F; Z is O; R 1 is independently selected from halogen, trihalomethyl, —CN, —NO 2 , —OR 20 , —N(R 20 )R 20 , —S(O) 0-2 R 20 , —SO 2 N(R 20 )R 20 , —CO 2 R 20 , —C(O)N(R 20 )R 20 , —N(R 20 )SO 2 R 20 , —N(R 20 )C(O)R 20 , —NHCO 2 R 20 , —C(O)R 20 , optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl; R 2 is H; each R 3a is independently selected from —H, halogen, trihalomethyl, —CN, —NO 2 , —OR 20 , —N(R 20 )R 20 , —S(O) 0-2 R 20 , —SO 2 N(R 20 )R 20 , —CO 2 R 20 , —C(O)N(R 20 )R 20 , —N(R 20 )SO 2 R 20 , —N(R 20 )C(O)R 20 , —NHCO 2 R 20 , —C(O)R 20 , optionally substituted C 1-6 alkyl, and optionally substituted heterocyclyl; each R 20 is independently —H, optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl; or two of R 20 , when taken together with a common nitrogen to which they are attached, can form an optionally substituted five- to seven-membered heterocyclyl, said optionally substituted five- to seven-membered heterocyclyl optionally containing at least one additional annular heteroatom selected from N, O, S, and P; and each R 70 is independently selected from —H, halogen, trihalomethyl, —CN, —NO 2 , —OR 20 , —N(R 20 )R 20 , —S(O) 0-2 R 20 , —SO 2 N(R 20 )R 20 , —CO 2 R 20 , —C(O)N(R 20 )R 20 , —N(R 20 )SO 2 R 20 , —N(R 20 )C(O)R 20 , —NHCO 2 R 20 , —C(O)R 20 , optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl.