Patent ID: 8338364

Claim:
A topical, oral or injectable formulation comprising an amount of a tyrosinase inhibitor effective to lighten skin pigmentation selected from the group consisting of a peptide having the sequence SFLLRN (SEQ ID NO: 1), and a peptide having no more than 2 amino acid substitutions to SFLLRN (SEQ ID NO: 1) according to replacement of an amino acid from column 1 with an amino acid from column 2: Column 1 Column 2 R K or L S T, A, L, M, I L I, V, A, M N D F R, W, Y said formulation further comprising a secondary skin whitening agent selected from the group consisting of one or more of 4 thioresorcin, 3-aminotyrosine, 5-hydroxy-2-hydroxymethyl-γ-pyridone, fomes japonicas extract, glabridin, glycyrrhizinic acid, catharanthus roseus extract, methyl 4-benzyloxy-2-hydroxybenzoate, and 4-benzyloxy-2-hydroxybenzoic acid.