Patent ID: 8466142

Claim:
A compound of formula (II-7): or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, optionally substituted C 1-6 aliphatic, —(CH 2 ) n CO 2 R 8 , —(CH 2 ) n CON(R 8 ) 2 , or —(CH 2 ) n COSR 8 ; wherein each R 8 is independently hydrogen, optionally substituted C 1-6 aliphatic, optionally substituted 6-10-membered aryl, or optionally substituted C 1-6 heteroaliphatic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and n is an integer from 0-4; R 2 is —NR 2 or —OR, wherein each instance of R is hydrogen; R 3 is -T-R z , wherein: T is a bivalent C 1-12 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of T are optionally and independently replaced by —O—, —S—, —N(R)—, —C(O)—, —C(O)O—, —OC(O)—, —N(R)C(O)—, —C(O)N(R)—, —S(O), —S(O) 2 —, —N(R)SO 2 —, or —SO 2 N(R)—, wherein each R is independently hydrogen, optionally substituted acyl, optionally substituted arylalkyl, optionally substituted C 1-6 aliphatic, or optionally substituted C 1-6 heteroaliphatic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and R z is —OR, —SR, or —NR 2 , wherein each R is independently optionally substituted phenyl, optionally substituted arylalkyl, or optionally substituted C 1-6 aliphatic, or two R on the same nitrogen atom are taken with the nitrogen to form an optionally substituted 4-7-membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R 4 is hydrogen or —OR, wherein R is hydrogen or an optionally substituted group selected from acyl, arylalkyl, C 1-6 aliphatic, or C 1-6 heteroaliphatic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and R 5 , R 6 , and R 7 are each hydrogen.