Patent ID: 8039487

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein: X is sulfur and Y is —CR 3 , or alternatively, X is —CR 3 and Y is sulfur; and R 3 is hydrogen, halogen, —CN, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy or lower-alkoxy-lower-alkyl; R 1 is aryl or heteroaryl, which aryl or heteroaryl can optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halogen, hydroxy, —CN, lower-alkyl and hydroxy-lower-alkyl; R 2 is aryl, heteroaryl or aryl-lower-alkyl, wherein said aryl or heteroaryl can optionally be substituted with 1 to 3 substituents independently selected from the group consisting of: (1) lower-alkyl, optionally substituted with hydroxy, —COOH, carbamoyl, amino, halogen or lower-alkoxy, (2) halogen, (3) hydroxy, (4) —CN, (5) —NO 2 , (6) fluoro-lower-alkyl, (7) lower-alkoxy, optionally substituted with hydroxy, —COOH, carbamoyl, amino, halogen or lower-alkoxy, (8) fluoro-lower-alkoxy, (9) —S(O 2 )R 4 , wherein R 4 is lower-alkyl or amino; (10) —C(O)R 5 , wherein R 5 is hydrogen, hydroxy, lower-alkyl, lower-alkoxy or amino; (11) imidazolyl, (12) pyrazolyl, (13) tetrazolyl, (14) pyrrolyl, and (15) —NR 6 R 7 , wherein R 6 and R 7 , independently from each other, are selected from the group consisting of hydrogen, lower-alkyl, lower-alkyl-carbonyl and lower-alkyl-SO 2 .