Patent ID: 7115611

Claim:
A Compound of the formula and enantiomers and pharmaceutically acceptable salts or esters thereof, wherein X 1 is O, S, CH 2 R 1 is hydrogen or C 1-7 -alkyl; R 2 is hydrogen or C 1-7 -alkyl, or, if X 1 is CH 2 , R 2 is hydrogen, C 1-7 -alkyl or C 1-7 -alkoxy; R 3 is hydrogen or C 1-7 -alkyl; R 4 and R 8 independently from each other are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 -alkyl, cyano-C 1-7 -alkyl or cyano; R 5 , R 6 and R 7 independently from each other are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 -alkyl, cyano-C 1-7 -alkyl or cyano; and one of R 5 , R 6 and R 7 is wherein X 2 is selected from the group consisting of S, O, NR 9 , (CH 2 ) p NR 9 CO, or (CH 2 ) p CONR 9 , R 9 is selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl, hydroxy-C 2-7 -alkyl, or C 1-7 -alkoxy-C 2-7 -alkyl; Y 1 , Y 2 , Y 3 and Y 4 are N or C—R 12 , and 1 or 2 of Y 1 , Y 2 , Y 3 and Y 4 are N and the other ones are C—R 12 ; R 10 is C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl, or C 1-7 -alkoxy-C 1-7 -alkyl; R 11 is hydrogen, C 1-7 -alkyl, C 1-7 -alkoxy-C 1-7 -alkyl; R 12 independently from each other is selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl, C 1-7 -alkoxy-C 1-7 -alkyl, hydroxy-C 1-7 -alkyl, C 1-7 -alkylthio-C 1-7 -alkyl, carboxy-C 1-7 -alkoxy-C 1-7 -alkyl, carboxy, carboxy-C 1-7 -alkyl, mono- or di-C 1-7 -alkyl-amino-C 1-7 -alkyl, C 1-7 -alkanoyl-C 1-7 -alkyl, C 2-7 -alkenyl, and C 2-7 -alkinyl; R 13 is aryl or heteroaryl; m is 0 or 1, n is 0, 1, 2 or 3, and p is 0, 1 or 2, and the sum of m, n and p is 1, 2, 3 or 4; provided that compounds of formula I are excluded, wherein X 1 is O, R 2 and R 3 are hydrogen, R 6 is equal to X 2 is O or S, and m is 0.