Patent ID: 8311620

Claim:
A cardiac rhythm management system, comprising: an implantable tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia; an implantable biologic therapy delivery device comprising an agent delivery device and a gene regulatory signal delivery device, the agent delivery device configured to deliver one or more agents including an expression cassette suitable for transiently terminating or preventing AF, the gene regulatory signal delivery device configured to deliver a regulatory signal carrying a form of energy suitable for regulating the expression cassette; a composition comprising the expression cassette comprising an energy regulatable transcriptional control element operably linked to a nucleic acid sequence for a gene product, wherein the gene product comprises sequences corresponding to those for an ion channel protein, a connexin, or a fragment thereof, wherein expression from the expression cassette in the atria of the mammal downregulates I Kur , I K1 or I f or upregulates connexin expression or activity; and an implant control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device, the control circuit programmed to trigger the delivery of the one or more agents including the expression cassette and the regulatory signal from the biologic therapy delivery device in an amount effective to restore or prolong action potential duration(APD) and/or effective refractory period (ERP) in response to a detection of a tachyarrhythmia classified as AF.