Patent ID: 7151116

Claim:
A functionalized isoapoptolidin compound consisting essentially of an isoapoptolidin core or a stereoisomer thereof, in which:s (a) at least one hydroxyl group in the isoapoptolidin core is replaced with a substituent selected from C 1 –C 24 hydrocarbyloxy, C 2 –C 25 acyloxy, C 2 –C 25 haloacyloxy C 2 –C 25 thioacyloxy, C 2 –C 25 thiohaloacyloxy, C 2 –C 25 carbonato, halogenated C 2 –C 25 carbonato, C 2 –C 25 thiocarbonato, halogenated C 2 –C 25 thiocarbonato, carbamoyloxy, N—(C 1 –C 24 hydrocarbyl)-substituted carbamoyloxy, N,N-di(C 1 –C 24 hydrocarbyl)-substituted carbamoyloxy, thiocarbamoyloxy, N—(C 1 –C 24 hydrocarbyl)-substituted thiocarbamoyloxy, N,N-di(C 1 –C 24 hydrocarbyl)-substituted thiocarbamoyloxy, sulfamoyloxy, N—(C 1 –C 24 hydrocarbyl)-substituted sulfamoyloxy, N,N-di(C 1 –C 24 hydrocarbyl)-substituted sulfamoyloxy, and protected hydroxyl groups; (b) at least one 1,3-diene functionality in the isoapoptolidin core is replaced by the product of a Diels-Alder reaction with a dienophile; (c) at least one carbon-carbon double bond in the isoapoptolidin core is replaced with a carbon-carbon single bond; and/or (d) at least one 1,2-diol functionality in the isoapoptolidin core is replaced with a cyclic ether.