Patent ID: 7968746

Claim:
A compound of formula I: where R is selected from the group consisting of: where the * indicates the point of attachment of R to the remainder of the molecule; R 1 , R 2 , and R 3 are independently selected from hydrogen and C 1 -C 6 -alkyl; R 4 is C 1 -C 6 -alkyl; R 5 and R 6 are independently selected from hydrogen, hydroxy, alkoxy, C 1 -C 40 -alkyl, C 1 -C 40 -alkenyl, C 1 -C 40 -alkynyl, and aryl; where the alkyl, alkenyl, alkynyl, or aryl groups may optionally be substituted with —OR 10 , —CN, —F, —Cl, —Br, —I, —NR 10 R 10 ′, oxo, C 3 -C 6 -cycloalkyl, aryl, aryl-C 1 -C 6 -alkyl, heteroaryl, heterocyclyl, —C(O)—R 11 , —C(O)—C 0 -C 6 -alkyl-aryl, —C(O)—O—R 11 , —C(O)—O—C 0 -C 6 -alkyl-aryl, —C(O)—N—R 11 R 11 , —C(O)—N—C 0 -C 6 -alkyl-aryl, —N—C(O)—R 11 , —N—C(O)—C 0 -C 6 -alkyl-aryl; where the aryl, heteroaryl and heterocyclyl ring substituents may be further substituted with C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, oxo, hydroxy, C 1 -C 6 -alkoxy, —C(O)—C 1 -C 6 -alkyl and —C(O)—O—C 1 -C 6 -alkyl; and where one of the carbons of the alkyl, alkenyl, or alkynyl groups may be substituted with a heteroatom selected from —O— or —N—; R 10 and R 10 ′ are independently selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, aryl, aryl-C 1 -C 6 -alkyl, heteroaryl, heterocyclyl, —C(O)—H, —C(O)—C 1 -C 6 -alkyl, —C(O)-aryl and —C(O)—C 1 -C 6 -alkyl-aryl; R 11 and R 11 ′ are selected from hydrogen and C 1 -C 6 -alkyl; and M and M′ are independently selected from hydrogen, —C(O)—R 12 , —C(O)—C 1 -C 6 -alkenyl, —C(O)—C 1 -C 6 -alkynyl, —C(O)-aryl; —C(O)-heteroaryl, —C(O)O—R 12 , —C(O)NR 12 R 12 , —SO 2 OR 12 , —SO 2 —C 1 -C 6 -alkyl, —SO 2 -haloC 1 -C 6 -alkyl; —SO 2 -aryl, —SO 2 —NR 12 R 12 , —P(O)(OR 12 )(OR 12 ), and C-linked mono or di-peptide, where R 12 is hydrogen or C 1 -C 6 -alkyl optionally substituted with —OH, —NH 2 , —NH(C 1 -C 4 alkyl), —N(C 1 -C 4 alkyl) 2 , —C(O)—OH, —C(O)—O—C 1 -C 4 -alkyl or halogen; with the proviso that the compound is not N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide or N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2,5-dihydroxy-3,4,6-trimethylphenyl)-2-hydroxy-2-methylbutanamide; or a salt, a stereoisomer, or a mixture of stereoisomers thereof.