Patent ID: 6903123

Claim:
A compound represented by the formula or a pharmaceutically acceptable salt or solvate thereof, or a diastereomer or enantiomer thereof, wherein: (a) R 1 is —(CH 2 ) n CHR 4 R 5 , fluorenyl, pyrimidinyl or n is 0, 1, 2 or 3; R 2 is H; and R 3 is —C(H)(R)—NR 7 R 8 ; R is H, aryl, R 6 -aryl, aryl(CH 2 ) 1-2 , R 6 -aryl(CH 2 ) 1-2 or heteroaryl; R 4 is H, aryl, R 6 -aryl, heteroaryl, C 1-6 alkyl, C 3-6 cycloalkyl or C 2-6 alkenyl; R 5 is aryl, R 6 -aryl, heteroaryl, C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl or fluorenyl, provided that when R 4 and R 5 are each phenyl, R is not phenyl or R 6 -phenyl; or R 4 is H and R 5 is tetrahydronaphthyl or tetrahydronaphthyl substituted with 1 or 2 substituents selected from the group consisting of halogen, C 1-6 alkoxy, hydroxy, C 1-6 alkyl and trihalo(C 1-6 )alkyl; R 6 is 1 or 2 substituents independently selected from the group consisting of halogen, C 1-6 alkoxy, hydroxy, phenyl, phenoxy, C 1-6 alkyl, trihalo(C 16 )alkyl, amino, amido, —NO 2 , naphthyl, benzoyl and benzyloxy, or 2 adjacent ring carbon atoms can be substituted by methylenedioxy; R 7 is —(CH 2 ) x R 9 , tetrahydronaphthyl, tetrahydronaphthyl substituted with 1 or 2 R 10 groups, or C 5 -C 7 cycloalkyl; and R 8 is H; or R 7 and R 8 together form a ring of the formula x is 0 to 10; R 9 is H, C 1 -C 6 alkoxy, phenyl, phenyl substituted with 1 or 2 R 10 groups, naphthyl, pyridyl, imidazolyl, furanyl, pyrrolidinyl, pyrrolidonyl, piperidinyl, N—(C 1 -C 6 alkyl)-piperidinyl, N-aryl(C 1 -C 6 alkyl)piperidinyl or diphenylmethyl; R 10 is independently selected from the group consisting of halogen, C 1 -C 6 alkoxy, C 1 -C 6 alkyl, —OCF 3 and methylenedioxy; R 11 is aryl(C 1 -C 6 )alkyl, di-aryl(C 1 -C 6 )alkyl or piperidinyl; and R 17 is H, C 1 -C 6 alkyl or benzyl; or (b) R 2 is —NHR 7 or and R 3 is H; and R 1 and R 7 are as defined in (a).