Patent ID: 7820649

Claim:
A compound of formula I, wherein R 1 is C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-3 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, said C 1-6 alkyl, C 3-6 cycloalkyl and C 3-6 cycloalkylC 1-3 alkyl being optionally substituted with hydroxy, C 1-6 alkyloxy, cyano or one or more halogens; R 2 is C 6-10 aryl optionally substituted with one to three substituents selected from halogen, hydroxy, cyano, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxy and C 3-6 cycloalkyloxy, said C 1-6 alkyl, C 3-6 cycloalkyl, alkyloxy and C 3-6 cycloalkyloxy being optionally substituted with one or more halogens; or R 2 is a 5-10 membered heteroaryl ring system comprising a heteroatom selected from N, O and S and optionally substituted with a substituent selected from methyl, C 1-6 alkyloxy and halogen; or R 2 is C 4-7 cycloalkyl; R 3 is an optional substituent selected from C 1-6 alkyl, C 1-6 alkyloxy and halogen, said C 1-6 alkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens; R 4 is a group located at the 6- or 7-position of the quinazolinone or isoquinolinone ring having the formula II wherein R 5 is joined together with one of R 7 and R 8 to have the structure of formula II form a 1,4-diazepine ring optionally substituted with one or two substituents selected from methyl, halogen, hydroxy and oxo; Each R 6 is independently H, halogen or C 1-4 alkyl optionally substituted with halogen or SO 2 CH 3 ; R 7 and R 8 are independently H, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-3 alkyl, cyanoC 1-3 alkyl, C 6-10 aryl, C 6-10 arylC 1-3 alkyl, C 1-3 alkyloxyC 1-3 alkyl or C 1-6 acyl said C 1-6 alkyl, C 3-6 cycloalkyl and C 3-6 cycloalkylC 1-3 alkyl being optionally substituted with hydroxy, 1 or more halogens or diC 1-2 alkylamino; Each R 12 is independently H or C 1-4 alkyl; m is 2 or 3; and X is N or CH, or a pharmaceutically acceptable salt thereof.