Patent ID: 7728034

Claim:
A method of treating an epileptic condition in a mammal, comprising administering to said mammal an effective amount of a selective persistent sodium channel antagonist, wherein said antagonist has at least 20-fold selectivity for a persistent sodium current relative to a transient sodium current, and wherein said antagonist is a compound included in formula 4, or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof: wherein, Ar 3 is phenyl or a substituted phenyl; Ar 4 is phenyl or a substituted phenyl; X 1 is absent or selected from the group consisting of Y 1 is absent or selected from the group consisting of R 8 and R 9 are independently selected from the group consisting of hydrogen, COCF 3 and a C 1 to C 8 alkyl; R 10 and R 11 are independently selected from the group consisting of hydrogen, hydroxy, halogen, and a C 1 to C 8 alkyl.