Patent ID: 7351705

Claim:
A carboxylic acid compound represented by formula (I): wherein R 1 represents (1) a hydrogen atom, (2) C 1-4 alkyl, (3) C 2-4 alkenyl or (4) benzyl; E represents —C(═O)—, —SO 2 — or —CH 2 —; R 2 represents (1) a halogen atom, (2) C 1-6 alkyl, (3) C 1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl, (9) nitro, (10) —NR 6 R 7 or (11) C 1-4 alkyl substituted with —OR 8 ; R 3 represents (1) a halogen atom, (2) C 1-6 alky, (3) C 1-6 alkoxy, (4) hydroxyl, (5) trihalomethyl, (6) cyano, (7) phenyl, (8) pyridyl, (9) nitro, (10) —NR 6 R 7 or (11) C 1-4 alkyl substituted with —OR 8 ; R 6 and R 7 each independently represents a hydrogen atom or C 1-4 alkyl; R 8 represents C 1-4 alkyl, phenyl or pyridyl; R 4 represents (1) a hydrogen atom, (2) C 1-6 alkyl or (3) benzyl; R 5 represents (1) C 1-6 alkyl, (2) C 1-10 alkoxy, (3) C 1-6 alkyl substituted with C 1-6 alkoxy, (4) a halogen atom, (5) hydroxyl, (6) trihalomethyl, (7) nitro, (8) —NR 9 R 10 , (9) phenyl, (10) phenoxy, (11) oxo, (12) C 2-6 acyl, (13) cyano or (14) —SO 2 R 11 ; R 9 and R 10 each independently represents a hydrogen atom or C 1-4 alkyl; R 11 represents C 1-6 alkyl; represents a C 5-12 monocyclic or bicyclic carbon ring or a 5- to 12-membered monocyclic or bicyclic hetero ring aryl having hetero atom(s) selected from one to four nitrogen atom(s), one to two oxygen atom(s) and/or one to two sulfur atom(s) and such hetero ring is saturated either partially or wholly; G represents (1) C 1-6 alkylene having 0 to 2 hetero atom(s) selected from an nitrogen atom, an oxygen atom and a sulfur atom, (2) C 2-6 alkenylene having 0 to 2 hetero atom(s) selected from an nitrogen atom, an oxygen atom and a sulfur atom or (3) C 2-6 alkynylene having 0 to 2 a hetero atom(s) selected from an nitrogen atom, an oxygen atom and a sulfur atom; represents a dihydrobenzoxazine ring; m represents 0 or an integer of 1 to 4; n represents 0 or an integer of 1 to 4; and i represents 0 or an integer of 1 to 11; wherein when m is 2 or more, R 2 are the same or different; when n is 2 or more, R 3 are the same or different; and i is 2 or more, R 5 are the same or different) or a pharmaceutically acceptable salt thereof.