Patent ID: 7160906

Claim:
A method for the treatment of a disease or medical condition in which inhibition of GLK is indicated, comprising administering a compound of Formula (I) or a salt, solvate, or prodrug thereof, to a patient in need thereof: wherein each R 1 is independently selected from OH, —(CH 2 ) 1-4 H, —CH 3-a F a , —(CH 2 ) 1-4 CH 3-a F a , halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, NO 2 , NH 2 , —NH—C 1-4 alkyl, —N-di-(C 1-4 alkyl), CN, or formyl; each R 2 is the group Y—X—; R 3 is selected from hydrogen or C 1-6 alkyl; each R 4 is independently selected from halo, —CH 3-a F a , CN, NO 2 , NH 2 , C 1-6 alkyl, —OC 1-6 alkyl, —COOH, —C(O)OC 1-6 alkyl, OH, phenyl or R 5 —X 1 ; R 5 is selected from hydrogen, C 1-6 alkyl, —CH 3-a F a , phenyl, naphthyl, heterocyclyl, and C 3-7 cycloalkyl, and is optionally substituted with halo, C 1-6 alkyl, —CH 3-a F a , CN, NO 2 , NH 2 , COOH, or —C(O)OC 1-6 alkyl, and each phenyl, naphthyl or heterocyclyl ring in R 5 is optionally substituted with halo, CH 3-a F a , CN, NO 2 , NH 2 , C 1-6 alkyl, —OC 1-6 alkyl, COOH, —C(O)OC 1-6 alkyl or OH; R 6 is independently selected from hydrogen, C 1-6 alkyl or —C 2-4 alkyl-O—C 1-4 alkyl; each X and X 1 is a linker independently selected from —O-Z-, —O-Z-O-Z-, —C(O)O-Z-, —OC(O)-Z-, —S-Z-, —SO-Z-, —SO 2 -Z-, —N(R 6 )-Z-, —N(R 6 )SO 2 -Z-, —SO 2 N(R 6 )-Z-, —(CH 2 ) 1-4 —, —CH═CH-Z-, —C≡C-Z-, —N(R 6 )CO-Z-, —CON(R 6 )-Z-, —C(O)N(R 6 )S(O) 2 -Z-, —S(O) 2 N(R 6 )C(O)-Z-, —C(O)-Z- or a direct bond; each Y is independently selected from aryl-Z 1 -, heterocyclyl-Z 1 -, C 3-7 cycloalkyl-Z 1 -, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl or —(CH 2 ) 1-4 CH 3-a F a ; wherein each Y is independently optionally substituted with up to three R 4 groups; each Z 1 is independently a direct bond or a group of the formula —(CH 2 ) p —C(R 6 ) 2 —(CH 2 ) q —; each Z 1 is independently a direct bond or a group of the formula —(CH 2 ) p —C(R 6 ) 2 —(CH 2 ) q —; each a is independently 1, 2 or 3; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4; and n+m>0; p is an integer between 0 and 2; q is an integer between 0 and 2; and p+q<4.