Patent ID: 8017144

Claim:
A method of forming an in-situ, in a living body, comprising the steps of: (a) dissolving a non-reactive, water-insoluble biodegradable polymer in a biocompatible, highly water soluble organic solvent that is dispersible in body fluid in situ to form a flowable composition; (b) adding an effective amount of a compound to the flowable composition to provide a pharmaceutical composition; (c) placing the pharmaceutical composition within the body; and (d) allowing the to dissipate to produce a solid or gel implant which releases the compound by diffusion, erosion or a combination of diffusion and erosion as the implant biodegrades; wherein the compound or a pharmaceutically acceptable salt thereof is selected from the group consisting of: (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic-acid; 7-[(4-butyl-benzyl)-methanesulfonyl-amino]-heptanoic acid; and 7-{[2-(3,5-dichloro-phenoxyl)-ethyl]-methanesulfonyl-amino}-heptanoic acid; wherein the polymer is selected from the group consisting of polylactides and copolymers, thereof with glycolide; and wherein the solvent is N-methyl-2-pyrrolidone (NMP).