Patent ID: 8507447

Claim:
A peptide or a pharmaceutically acceptable salt thereof, wherein the peptide comprises the amino acid sequence Xaa 1 Xaa 2 Xaa 3 Xaa 4 Cys 5 Xaa 6 Xaa 7 Xaa 8 Cys 9 Asn 10 Pro 11 Ala 12 Cys 13 Xaa 14 Gly 15 Xaa 16 Xaa 17 (SEQ ID NO:1), or a pharmaceutically acceptable salt thereof; wherein Xaa 1 is Asn, D-Asn, Gln, D-Gln, Pro, Ala, β-Ala, D-Ala, Val, D-Val, Gly, Thr, D-Thr, Asp, D-Asp, γ-carboxylated Asp, Glu, D-Glu, γ-carboxylated Glu, α-aminosuberic acid (Asu), α-aminoadipic acid (Aad), α-aminopimelic acid (Apm), or is absent; Xaa 2 is Asp, γ-carboxylated Asp, Glu, γ-carboxylated Glu, Asu, Aad, Apm, or is absent; Xaa 3 is Asp, γ-carboxylated Asp, Glu, γ-carboxylated Glu, Asu, Aad, Apm, or is absent; Xaa 4 is Cys or D-Cys; Xaa 6 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, P-homo-Thr, P-Cys or P-Tyr; Xaa 7 is Tyr, Leu, Phe or Ile; Xaa 8 is Cys or D-Cys; Xaa 14 is Thr, Ala or Phe; Xaa 16 is Cys or D-Cys; and Xaa 17 is Tyr, D-Tyr, or is absent; wherein: if Xaa 1 is present, Xaa 1 may be modified on its amino group by methyl, ethanedioic acid, propanedioic acid, butanedioic acid, pentanedioic acid, hexanedioic acid, heptanedioic acid or octanedioic acid; if Xaa 1 is absent and Xaa 2 is present, then Xaa 2 may be modified on its amino group by methyl, ethanedioic acid, propanedioic acid, butanedioic acid, pentanedioic acid, hexanedioic acid, heptanedioic acid or octanedioic acid; or if both Xaa 1 and Xaa 2 are absent, then Xaa 3 may be modified on its amino group by methyl, ethanedioic acid, propanedioic acid, butanedioic acid, pentanedioic acid, hexanedioic acid, heptanedioic acid or octanedioic acid.