Patent ID: 8048844

Claim:
A method of inhibiting hypersecretion of mucus by mucus-producing goblet cells in lungs of a mammalian subject having an airway hypersecretory disease, the method comprising: administering to the mammalian subject a therapeutically effective amount of an epidermal growth factor receptor (EGF-R) antagonist that binds the EGF-R, wherein said administering results in a reduction of hypersecretion of mucus in the lungs of said subject, wherein the airway hypersecretory disease is chronic bronchitis, asthma, bronchiectasis, pulmonary fibrosis, chronic obstructive pulmonary disease, or cystic fibrosis, and wherein said EGF-R antagonist is an EGFR-selective tyrosine kinase inhibitor of the formula: wherein X is optionally substituted phenyl, or a pharmaceutically acceptable salt thereof.