Patent ID: 8252606

Claim:
A sensor comprising: a redox active protein, which, upon interaction with a thiol analyte, undergoes a change in a physical property, and a transducer, which, upon the change in the physical property of the redox active protein, converts the change in the physical property into an electrical signal, wherein the redox active protein is selected from the group consisting of: a protein having two cysteine residues that can reversibly form a disulfide bond; a protein having at least one prosthetic group selected from the group consisting of flavin adenine dinucleotide (FAD), nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotidephosphate (NADP), and flavin mononucleotide (FMN); a metalloprotein comprising copper; a metalloprotein comprising a non-heme iron; a metalloprotein comprising a heme-bound iron, selected from the group consisting of cytochrome c, myoglobin, and hemoglobin; and a membrane protein comprising a redox active group.