Patent ID: 8597885

Claim:
A method of administering an aggressive breast cancer treatment comprising chemotherapy and/or radiation to an ER+ human breast cancer patient, said method comprising: providing a primary ER+ breast tumor tissue that has been surgically removed from a breast cancer patient; assaying mRNA expression levels of a gene panel consisting of a CDC6, MKI67, and SPAG5 gene in the primary ER+ breast tumor tissue; comparing said mRNA expression levels to the mRNA expression levels of the gene panel in a reference population of ER+ breast tumor tissues; and administering an aggressive breast cancer treatment comprising chemotherapy and/or radiation to the ER+ human breast cancer patient when the primary ER+ breast tumor tissue has a higher mRNA expression level than the level in the reference population for at least one gene in the gene panel, or not administering an aggressive breast cancer treatment comprising chemotherapy and/or radiation to the ER+ human breast cancer patient when the patient primary ER+ breast tumor tissue has a lower mRNA expression level of each gene of the gene panel consisting of a CDC6, MKI67, and SPAG5 gene than the mRNA expression level of each gene of the gene panel in the reference population.