Patent ID: 8691977

Claim:
At least one chemical entity chosen from compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R 1 is chosen from hydrogen, optionally substituted alkyl, optionally substituted acyl, optionally substituted aminocarbonyl, optionally substituted alkoxycarbonyl, —P(═O)(OR a )(OR b ), and —C(R c )(R d )OP(═O)(OR a )(OR b ), where R a , R b , R c , and R d are independently chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; X is chose from −OR 2 and —NR 3 R 4 ; R 2 is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heteroclycloalkyl, optionally substituted acyl, optionally substituted aminocarbonyl, and optionally substituted alkoxycarbonyl; R 3 is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heteroclycloalkyl, optionally substituted acyl, optionally substituted aminocarbonyl, optionally substituted alkoxycarbonyl, and optionally substituted sulfonyl; and R 4 is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heteroclycloalkyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, and optionally substituted heterocycloalkyloxy; or R 3 and R 4 may optionally be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring provided that the compound of Formula I is not (6bS,8aS,11R,12aR,12bS,14aR)-3-hydroxy-11-(hydroxymethyl)-4,6b,8a,11,12b,14a-hexamethyl-7,8,8a,9,10,11,12,12a,12b,13,14,14a-dodecahydropicen-2(6bH)-one.