Patent ID: 8426460

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: A is a single or double bond; B is a single or double bond; R 1 and R 5 are independently hydrogen, hydroxyl, oxo, oximino or alkoxyimino, provided that R 1 is hydroxyl only when A is a single bond, and that R 5 is hydroxyl only when B is a single bond; R 2 and R 6 are independently linear or branched C 1 -C 8 alkyl, C 2 -C 8 alkenyl, or C 3 -C 8 cycloalkyl; R 3 and R 7 are independently hydroxyl, methoxy, oxo, hydroximino, or alkoxyimino; R 4 and R 8 are independently hydrogen, hydroxyl, C 1 -C 8 alkanoyloxy, benzoyloxy, di-C 1 -C 8 alkylamino benzoyloxy, (C 1 -C 8 alkoxy) p , C 1 -C 8 alkylthio, C 1 -C 8 alkylthioalkoxy or oleandrosyloxy; R 9 and R 10 are independently diradical groups selected from a bond, O, NR 11 , —NR 11 C(═O)—, —NR 11 C(═S)—, —NR 11 C(═O)O—, —ONR 11 C(═O)—, —ONR 11 C(═O)O—, —ONR 11 C(═O)NR 11 —, —OC(═O)O—, —N(R 11 )C(═O)N(R 11 )—, —N(R 11 )C(═S)N(R 11 )—, —N(R 11 )S(O) 2 N(R 11 )—, —N(R 11 )S(O) 2 —, —N(R 11 )S(O)N(R 11 )—, —N(R 11 )S(O)—, —C(═NR 11 )—, —C(═O)—, —C(═O)N(R 11 )—, and —C(═S)N(R 11 )—; R 11 is H or R 2 ; L is a diradical linker selected from a bond, C 1 -C 20 alkylene, C 2 -C 20 alkenylene, C 2 -C 20 alkynylene, C 3 -C 8 cycloalkylene, arylene, aryloxy arylene, heteroarylene, or any combination thereof, which may optionally contain a N, O, S, P, or Si atom; and wherein said linker may optionally be substituted with one or more groups selected from cyano, nitro, hydroxy, halogen, O, N, S, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, oxo, oximino, and alkoxyimino; m and n are independently 1, or 2; and p is 1-3; wherein R 9 and R 10 may be connected to any two atoms of linker L.