Patent ID: 8039444

Claim:
A pharmaceutical composition comprising: (a) an antisense compound; (b) a branched chain permeation enhancer comprising an acid functional group-containing compound of Formula I in which at least about 50% of the total number of acid functional groups present have been reacted with a base, the compound of Formula I comprising: wherein: Q is selected from the group consisting of a —COOH functional group, a —SO 3 H functional group, an alkyl or alkenyl group having one to about 12 carbon atoms which is mono- or di-substituted with a substituent selected independently for each occurrence from the group consisting of a —COOH functional group and a —SO 3 H functional group; R 1 and R 2 are selected independently from the group consisting of an alky or alkenyl group from one to about 12 carbon atoms which is optionally substituted with a functional group selected independently for each occurrence from the group consisting of a —COOH functional group, a —SO 3 H functional group, an —NH 2 functional group, a —CONH 2 functional group, and a —OH functional group; and (c) a pharmaceutically acceptable vehicle, wherein said antisense compound and permeation enhancer are combined in a composition formulated for transdermal administration or transmucosal administration, and wherein the permeation enhancer is present in an amount sufficient to increase the bioavailability of the antisense compound upon transdermal administration or transmucosal administration of the composition to a patient.