Patent ID: 7364656

Claim:
An affinity ligand-matrix conjugate comprising the matrix and, conjugated thereto by the group Z, a ligand having the general formula (I): wherein one X is N and the other X is N, CCl or CCN; A 1 is O, S or N—R 1 and R 1 is H, C 1-6 alkyl, C 1-6 hydroxyalkyl, benzyl or β-phenylethyl; A 2 is NH; B 1 is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; B 2 is —CHCOOH—(CH 2 ) 1-4 —; D 1 is H or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidine or amidino group; and D 2 is a secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidine or amidino group; or B 2 —D 2 is —CHCOOH—(CH 2 ) 3-4 —NH 2 ; and p is 0 or 1.