Patent ID: 8544162

Claim:
A method of manufacturing a radiographic marker capable of being permanently implanted in a living human or animal subject, the method comprising: forming a fully implantable, biocompatible container from a nonbiodegradable solid material and defining an internal chamber; and sealing a contrast agent within the internal chamber, the contrast agent configured to produce a change in signal intensity in a magnetic resonance (MR) imaging modality with the marker fully implanted in the subject, wherein the solid material of the container includes a first magnetic susceptibility and the contrast agent includes a second magnetic susceptibility, wherein the solid material and the contrast agent are configured such that the first and second magnetic susceptibilities are matched so that the first magnetic susceptibility is substantially equivalent to the second magnetic susceptibility, wherein the permanently implantable radiographic marker is sized and shaped to fit within a lumen of a cannula configured to deliver the marker to a fully implanted location within the subject.