Patent ID: 8792614

Claim:
A method of radiotherapy treatment planning, comprising: determining a set of beam geometry and dosimetric parameters from a totality of beams; calculating dose deposition coefficients responsive to the beam geometry and dosimetric parameters; generating a set of points corresponding to a tissue volume, wherein each of the points corresponds to a place of interaction of a beam with a tissue volume; identifying a solution subset of beams from the totality of beams; evaluating the solution based on one of an objective, fitness, or cost function; and activating a radiation source in accordance with the solution, wherein the objective function comprises a quadratic function of the form: F fit ⁡ ( x ⇀ , w ⇀ , d ⇀ , v ⇀ ) = Θ ⁡ ( v t , min - v p , min ) ⁢ ⁢ w t , min ⁢ ⁢ ∑ 1 n t ⁢ Θ ( ⁢ δ thres , min - ∑ 1 b ⁢ DDC ij ⁢ x j ) ⁢ ⁢ ( ∑ 1 b ⁢ DDC ij ⁢ x j - d p , min ) 2 + Θ ⁡ ( v t , max - v p , max ) ⁢ ⁢ w t , max ⁢ ⁢ ∑ 1 n t ⁢ Θ ( ⁢ ∑ 1 b ⁢ DDC ij ⁢ x j - δ thres , max ) ⁢ ⁢ ( ∑ 1 b ⁢ DDC ij ⁢ x j - d p , max ) 2 + ∑ l = 1 org ⁢ [ ∑ m = 1 c l ⁢ ⁢ m ⁢ [ Θ ⁡ ( v l ⁢ ⁢ m - v p , l ⁢ ⁢ m ) ] ⁢ w l ⁢ ⁢ m ⁢ ⁢ ⁢ ∑ 1 n l ⁢ Θ ( ⁢ ∑ 1 b ⁢ DDC kj ⁢ ⁢ x j - δ thres , l ⁢ ⁢ m ) ⁢ ⁢ ( ∑ 1 b ⁢ DDC kj ⁢ x j - d p , l ⁢ ⁢ m ) 2 ] .