Patent ID: 7259266

Claim:
The compound selected from the group consisting of (2R)-6-chloro-7-isobutyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-7-isobutyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; (2R)-7-benzyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 7-benzyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 7-butoxy-6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 7-benzyl-6-bromo-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 7-butyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6,8-dichloro-7-(2-ethylbutoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-8-methyl-7-propoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-7-(isobutylthio)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-7-(2-ethylbutoxy)-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-7-(isopentyloxy)-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 8-methyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6,8-dichloro-7-isobutoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 7-benzyl-6-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 7-(sec-butylthio)-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; (2S)-6-ethyl-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-8-(4-chloro-3-methylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 8-ethyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; (2S)-8-ethyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; (2S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid 6-chloro-8-(4-methylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-8-(3-fluoro-4-methylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 8-propyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 5-bromo-6,7-dichloro-8-methoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; 6-chloro-8-(4-ethylphenyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; and (2S)-6,8-dimethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid; or their isomer and pharmaceutically acceptable salt thereof.