Patent ID: 7199147

Claim:
A method of treating disease through inhibiting Rho kinase, wherein the disease is selected from the group consisting of hypertension, angina, cerebral vasospasm, asthma, prostatic hypertrophy, blood vessel restinosis, cardiac hypertrophy, glaucoma, erectile dysfunction, and urinary incontinence, said method comprising administering a therapeutically effective amount of a compound represented by the formula (5): wherein the groups represented by the formulas R 1a and X a are as follows: (i) R 1a is a substituted or unsubstituted alkyl group and X a is a single bond, or (ii) R 1a is a carboxyl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted cycloalkenyl group, a substituted or unsubstituted alkoxycarbonyl group, a substituted or unsubstituted alkylsulfonyl group, a substituted or unsubstituted arylsulfonyl group, or a cycloalkyl group substituted by a substituted or unsubstituted alkyl group, and X a is a group represented by the formula: —O—, —C(═O)N(R 3 )—, —S(O) n —, —S(O) 2 N(R 3 )— or —C(═O)— R 1b is a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted cycloalkenyl group; X b is a group represented by the formula: —O—, —N(R 3 )—, —NHC(═O)—, or —C(═O)NH—, both of the groups represented by the formulas R 1c -X c and R 1d -X d are hydrogen atoms, provided that when R 1a is an unsubstituted alkyl group, the corresponding X a is not the group represented by the formula: —C(═O)—; R 3 is a hydrogen atom, an unsubstituted alkyl group, an unsubstituted cycloalkyl group, or an unsubstituted arylalkyl group, R 51 is a hydrogen atom, a halogen atom, a nitro group, a carboxyl group, an unsubstituted alkyl group, an unsubstituted cycloalkyl group, an unsubstituted cycloalkenyl group, an unsubstituted alkoxycarbonyl group, or a group represented by the formula: —OR 8 , —N(R 9 )R 10 , —CON(R 9 )R 10 , —SO 2 N(R 9 )R 10 or —S(O) m R 11 , m is 0, 1 or 2, each of R 8 , R 9 and R 10 , which may be the same or different, is a hydrogen atom, an unsubstituted alkyl group, an unsubstituted cycloalkyl group, an unsubstituted cycloalkenyl group, an unsubstituted alkoxycarbonyl group, or an unsubstituted arylalkyl group, R 11 is an unsubstituted alkyl group, an unsubstituted cycloalkyl group, an unsubstituted cycloalkenyl group, or an unsubstituted arylalkyl group, and R 6 is a hydrogen atom, an unsubstituted alkyl group, an unsubstituted cycloalkyl group, an unsubstituted cycloalkenyl group, an unsubstituted alkoxycarbonyl group, or a group represented by the formula: —CON(R 9 )R 10 , —SO 2 N(R 9 )R 10 or —S(O) mR 11 ; a prodrug of said compound, or a pharmaceutically acceptable salt of said compound or prodrug.