Patent ID: 8822434

Claim:
A phosphonate or phosphinate N-methanocarba derivative of AMP selected from, wherein Q 1 is O or S; R 1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, halogen, or N(R 6 ) 2 , wherein each R 6 is independently hydrogen, optionally substituted alkyl, or optionally substituted cycloalkyl; R 2 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkynyl, N(R 6 ) 2 , or halogen; R 3 is hydrogen, optionally substituted alkyl, N(R 6 ) 2 , or halogen; R 4 is hydroxyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted —Oaryl, or N(R 6 ) 2 ; R 5 is hydroxyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, or optionally substituted —Oaryl; or alternatively, R 4 and R 5 form a 5- or 6-membered cyclic structure with the phosphorus atom where the cyclic structure contains at least two oxygen atoms attached to the phosphorous atom and at least 2 carbon atoms, wherein the carbon atom or atoms closest to the phosphorous atom are optionally substituted with alkyl or aryl; and Y is a linking group linked to the phosphorus atom by a carbon atom, and is optionally substituted C 1 -C 6 alkylene, optionally substituted C 1 -C 6 alkenylene, optionally substituted C 1 -C 6 alkynylene, or optionally substituted —C 1 -C 6 alkylene-O—C 1 -C 6 alkylene; wherein X is O or S; n is 1, 2, or 3; and R 7 is optionally substituted alkyl or optionally substituted aryl; wherein Z is a bond or —O—C(═O)— where the carbonyl carbon is bonded to the oxygen of the bicycle group and the oxygen is bonded to the phosphorus atom; wherein R 8 is hydrogen or optionally substituted alkyl; R 8 is optionally substituted alkyl, optionally substituted alkoxy, or optionally substituted aryl; and R 9 is methoxy; wherein G is O or S—S; and R 10 is hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted alkoxy, or optionally substituted aryl; wherein R 11 is hydrogen, optionally substituted alkyl, or optionally substituted aryl, and wherein Q 1 is O or S; Q 2 is O or S; with the proviso that when Q 1 and Q 2 are both O, and Formula (VII) is not enriched with deuterium, then R 4 and R 5 are not both hydroxyl, a deuterium enriched isomer thereof, or a pharmaceutically acceptable salt thereof.