Patent ID: 8409573

Claim:
A method for inhibiting proliferation or killing CD71 positive malignant tumor cells, comprising providing to a patient in need thereof an anti-CD71 monoclonal antibody or an antigen-binding fragment thereof, wherein said anti-CD71 monoclonal antibody comprises (a) at least one heavy chain variable region comprising the amino acid sequence of SEQ ID No. 1 and at least one light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID No. 2 and SEQ ID No. 11; or (b) at least one heavy chain variable region encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID No. 3 and at least one light chain variable region encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID No. 4 and SEQ ID No. 12 under conditions and in an amount sufficient for the binding of said anti-CD71 monoclonal antibody to the malignant tumor cells, thereby causing inhibition of proliferation or killing of the malignant tumor cells.