Patent ID: 7662821

Claim:
A compound of formula (I) in which R 1 and R 2 , independently of one another, mean a hydrogen atom, a hydroxy group, a halogen atom, an optionally substituted (C 1 -C 10 )-alkyl group, an optionally substituted (C 1 -C 10 )-alkoxy group, a (C 1 -C 10 )-alkylthio group, a (C 1 -C 5 )-perfluoroalkyl group, a cyano group, or a nitro group, or R 1 and R 2 together mean —O—(CH 2 ) n —O—, —O—(CH 2 ) n —CH 2 —, —O—CH═CH—, —(CH 2 ) n+2 —, —NH—(CH 2 ) n+1 , N(C 1 -C 3 -alkyl)-(CH 2 ) n+1 , or —NH—N═CH—, wherein n=1 or 2, and the terminal oxygen atoms and/or carbon atoms and/or nitrogen atoms are linked to directly adjacent ring-carbon atoms, or NR 8 R 9 , wherein R 8 and R 9 , independently of one another, are hydrogen, C 1 -C 5 -alkyl or (CO)—C 1 -C 5 -alkyl, R 3 means a C 1 -C 10 -alkyl group that is optionally substituted by 1-3 hydroxy groups, halogen atoms, 1-3 (C 1 -C 5 )-alkoxy groups, an optionally substituted (C 3 -C 7 )-cycloalkyl group, an optionally substituted heterocyclyl group, an optionally substituted aryl group, a monocyclic or bicyclic heteroaryl group that optionally contains 1-4 nitrogen atoms and/or 1-2 oxygen atoms and/or 1-2 sulfur atoms and/or 1-2 keto groups and that optionally is substituted by one or more (C 1 -C 5 )-alkyl groups which optionally can be substituted by 1-3 hydroxy groups or 1-3 COOR 13 groups, wherein R 13 means hydrogen or a C 1 -C 5 -alkyl group; (C 1 -C 5 )-alkoxy groups, halogen atoms, hydroxy groups, NR 8 R 9 groups, exomethylene groups, or oxygen, which group is linked via any position to the amine of the tetrahydronaphthalene system and is optionally hydrogenated at one or more locations, R 4 means a hydroxy group, a group OR 10 or an O(CO)R 10 group, wherein R 10 means a hydroxy protective group or a C 1 -C 10 -alkyl group, R 5 means a (C 1 -C 10 )-alkyl group or an optionally partially or completely fluorinated (C 1 -C 10 )-alkyl group, a (C 3 -C 7 )cycloalkyl group, a (C 1 -C 8 )alkyl(C 3 -C 7 )cycloalkyl group, a (C 2 -C8)alkenyl(C 3 -C 7 )cycloalkyl group, a heterocyclyl group, a (C 1 -C 8 )alkylheterocyclyl group, a (C 2 -C 8 )-alkenylheterocyclyl group, an aryl group, a (C 1 -C 8 )alkylaryl group, a (C 2 -C 8 )alkenylaryl group, a (C 2 -C 8 )alkinylaryl group, a monocyclic or bicyclic heteroaryl group that contains 1-3 nitrogen atoms and/or 1-2 oxygen atoms and/or 1-2 sulfur atoms and that optionally substituted by 1-2 keto groups, 1-2 (C 1 -C 5 )-alkyl groups, 1-2 (C 1 -C 5 )-alkoxy groups, 1-3 halogen atoms or 1-2 exomethylene groups; a (C 1 -C 8 )alkylheteroaryl group, a (C 2 -C 8 )alkenylheteroaryl group, or a (C 2 -C 8 )alkinylheteroaryl group, which groups is linked to the tetrahydronaphthalene system via any position and is optionally hydrogenated at one or more locations, and R 6 and R 7 , independently of one another, mean a hydrogen atom, a methyl or ethyl group or together with the carbon atom of the tetrahydronaphthalene system mean a (C 3 -C 6 )-cycloalkyl ring, or a pharmaceutically acceptable salt thereof.