Patent ID: 8278280

Claim:
A composition of matter of the formula: F′—R z , or a physiologically acceptable salt thereof, wherein: F′ is a multivalent polyethylene glycol (PEG) of combined molecular mass of about 1,000 Daltons to 100,000 Daltons; R is independently in each instance —(X 1 )—(Y 1 ) n wherein R is covalently bound to F′; X 1 and Y 1 are independently in each instance peptides of the formula -L 1 -P 1 and -L 2 -P 2 , respectively; L 1 and L 2 are independently in each instance absent or linkers; n is 0; Z is 2 to 8; and P 1 and P 2 are independently in each instance peptide antagonists of the bradykinin B1 receptor comprising an amino acid sequence selected from SEQ ID NOS: 15-18, 23, 25, 26, 39-41, 43, 44, and 46-54.