Patent ID: 8080523

Claim:
A composition of matter comprising ShK attached to a chemical entity that has an anionic charge, said chemical entity comprising an entity selected from; AEEAc-L-Tyr(PO 3 H 2 ), AEEAc-L-Pmp(OH 2 ), AEEAc-D-Pmp(OH 2 ), AEEAc-D-Pmp(OH, Et), AEEAc-L-Pmp(Et 2 ), AEEAc-D-Pmp(Et 2 ), AEEAc-L-Tyr, AEEAc-L-Phe(p-NH 2 ), AEEAc-L-Phe(p-CO 2 H), AEEAc-L-Aspartate, AEEAc-D-Aspartate, AEEAc-L-Glutamate, or AEEAc-D-Glutamate, wherein said chemical entity is attached to the N-terminal residue of ShK.