Patent ID: 8440841

Claim:
A non-peptidyl CbR (Caspase binding Radioligand) or CbR-transporter conjugate that is a 5-pyrrolidinylsulfonyl isatin derivative having the formula 1, wherein, R 2 is an optionally substituted alkyl, heteroalkyl, aralkyl, heteroarylalkyl, carboxymethyl or methyloxycarbonylmethyl group, wherein the substituents are selected from F, I, Br, OH, NH 2 , methylamino, methoxy, fluoroethyloxy, fluoropropyloxy, trimethylamino, nitro, tosylate, triflate, mesylate, diazonium N 2 + , 3-fluorobenzoyl, 4-fluorobenzoyl, 4-fluorophenyl, tributylstannyl, trimethylstannyl, trimethylsilyl, 2-hydrazino-pyridin-5-carbonyl; or a metal-chelator or a metal-chelator bound to an aralkyl, aminoalkyl, hydroxyalkyl or piperazin-1-carbonylmethyl group; and optionally additionally comprises a spacer, linker or molecular transporter selected from Annexin V, PEG 1-200 , an oligopeptide, polyimide, polysaccharide, —NHC(O)—((CH 2 ) n —NH—C(O)) m —, —O—((CH 2 ) n —O) m —, succinyl and 1,4-disubstituted 1,2,3-triazole units, wherein n=0-6 and m=1-200 and wherein R 2 can also contain an amino acid selected from histidine, lysine, tyrosine, cysteine, arginine and aspartic acid; wherein R 2 is labelled with a positron-emitting non-metal radionuclide selected from C-11, N-13, and F-18.