Patent ID: 7629475

Claim:
A compound of formulas VIa or VIb: wherein W 3 is selected from O—R 3 , O-acyl, S—R 3 , S-acyl, NH-acyl, NHC(O)NH-acyl, NHC(O)Z 5 , and NR 29 R 30 ; A is selected from X 2 is selected from O—R 2 , O-acyl, OC(O)Z 2 , S—R 2 , S-acyl, SC(O)Z 2 , NR 16 R 17 , NH-acyl, NHC(O)NH-acyl, and NHC(O)Z 2 ; X 6 is O; Z 2 is OR 2 , SR 2 , or NR 16 R 17 ; Z 5 is OR 24 , SR 24 , or NR 25 R 26 ; and each of R 2 , R 3 , R 16 , R 17 , R 24 , R 25 , R 26 , R 29 , and R 30 is, independently, selected from H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 2-7 heterocyclyl, C 6-12 aryl, C 7-14 alkaryl, C 3-10 alkheterocyclyl, and C 1-8 heteroalkyl, or one or more of R 16 and R 17 , R 25 and R 26, and R 29 and R 30 combine to form a heterocyclic ring containing a nitrogen atom and wherein said compound is a selective kappa receptor antagonist, a selective kappa receptor partial agonist, or a selective kappa receptor agonist.