Patent ID: 8530002

Claim:
A method of attaching alkene-functionalized ceragenins to a surface of a polymer substrate using a silane-based coating and a Type-I compound, comprising, in the order listed: a) applying a silane-based coating to a surface of a polymer substrate, wherein the coating contains free amine groups; b) treating the silane-based coating with a Type-I compound comprising acid halides with an attached halogen atom that can be abstracted to leave a stable radical; c) contacting the Type-I treated surface with a monomer solution comprising an alkene-functionalized ceragenin monomer, a comonomer, and a solvent; d) adding a copper-based catalyst and a nitrogen-based ligand to the monomer solution contacting the surface, thereby initiating an atom-transfer radical polymerization (ATRP) reaction; and e) forming ceragenin-containing copolymer reaction products that are chemically grafted to the surface of the polymer substrate via amide and siloxane linkages; wherein no UV light is required to initiate the polymerization reaction.