Patent ID: 7585834

Claim:
A composition comprising a conjugate of a biologically active compound, a transport moiety and a self-immolating linker moiety linking the biologically active compound and the transport moiety, wherein the transport moiety comprises a structure selected from the group consisting of (ZY) n Z, (ZYZ) n Z, (ZYY) n Z, and (ZYYY) n Z, wherein each Z is L-arginine or D-arginine, and each Y is independently an amino acid that does not comprise an amidino or guanidino moiety, and wherein n is an integer of from 2 to 10, wherein the conjugate has a structure selected from wherein R 1 is the biologically active compound; X is a linkage between a functional group on the biologically active compound and a functional group on the linker between R 1 and R 3 ; Q is a linkage between a functional group on the transport moiety and a functional group on the linker between R 1 and R 3 ; A is N or CH; Ar is a substituted or unsubstituted aryl group, wherein the methylene and oxygen substituents are either ortho or para to one another; R 2 is hydrogen, alkyl, aryl, arylalkyl, acyl or allyl; R 3 is the transport moiety; R 4 is S, O, NR 6 or CR 7 R 8 ; R 4a is S, O, NR 6 or CR 7a R 8a ; R 5 is OH, SH, NHR 6 , or —CONH 2 ; R 5a is H, OH, SH, NHR 6 , or —CONH 2 ; R 6 is hydrogen, alkyl, aryl, arylalkyl, acyl or allyl; R 7 and R 8 are independently hydrogen, alkyl or arylalkyl; and R 7a and R 8a are independently hydrogen or alkyl; and k and m are independently either 1 or 2; and n1 is an integer of from 1 to 10.