Patent ID: 7906546

Claim:
A compound of the formula (I) wherein n is an integer selected from 0 to 3; R 1 is independently selected from the group consisting of halogen, —CN, —NO 2 , —SO 2 Me, lower alkyl, trifluoromethoxy, —OR 11 , piperidinyl, pyrrolidinyl, and —N(R 11 )(R 11 ), wherein R 11 is independently selected from lower alkyl and H, X 1 , X 2 , X 3 , and X 4 are independently selected from nitrogen and carbon, provided that no more than two of X 1 , X 2 , X 3 , and X 4 can be nitrogen at one time, and when two of X 1 , X 2 , X 3 , and X 4 are nitrogen, n is 0, 1, or 2; k is an integer from 0 to 1; R 2 is H; R 3 is H, alkyl, or halogen; R 4 is aryl, heteroaryl, alkylaryl or alkylheteroaryl, all being optionally substituted with from one to five substituents independently selected from the group consisting of halogen, alkyl, —OR 41 , lower alkynyl, and NR 42 R 43 , wherein R 41 is lower alkyl or —H, R 42 and R 43 independently from each other are hydrogen or alkyl, or NR 42 R 43 is piperidinyl or pyrrolidinyl, or R 4 is alkyl; R 5 is selected from the group consisting of said aryl and heteroaryl being optionally substituted at one or more positions with one or more substituents independently selected from the group consisting of H, halogen, lower alkyl and (CH 2 ) v R 53 , wherein R 51 is selected from the group consisting of H, alkyl, lower alkenyl and alkylaryl, said alkylaryl being optionally substituted at one or more positions with one or more of lower alkyl, —CN, halogen, —COOR 54 , and —CH 2 OR 54 , wherein R 54 is alkyl or —H; R 52 is lower alkyl or —H; R 53 is H, alkyl, cycloalkyl, —COOR 55 , —N(R 55 )(R 56 ), —CH 2 OH, —CN, CF 3 , —CONH 2 , —CH 2 OR 55 or —CONR 55 R 56 , wherein R 55 is independently selected from the group consisting of alkyl, —H, —C(O)-aryl, —C(O)-alkyl, or —C(O)-heteroaryl, and R 56 is selected from the group consisting of H, alkyl, C(O)CF 3 , —C(O)-aryl, —C(O)-alkyl, —C(O)-heteroaryl, alkylaryl and alkylheteroaryl, and wherein said aryl, heteroaryl, alkylaryl and alkyl-heteroaryl are optionally substituted at one or more positions with one or more of alkyl, —CN, halogen, —COOR 57 , and —CH 2 OR 57 , wherein R 57 is lower alkyl or —H, or R 55 and R 56 together with the atom to which they are attached form a ring; or R 53 is aryl which can optionally be substituted with benzyloxy, carboxy, lower-alkoxy-carbonyl, hydroxy-lower-alkyl, halogen, carbamoyl, lower-alkyl-carbamoyl, di-lower-alkyl-carbamoyl, m is an integer selected from 0 to 2; v is an integer selected from 0 to 4; and pharmaceutically-acceptable salts and/or pharmaceutically-acceptable esters thereof.