Patent ID: 8481524

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein R A is wherein each of R 1 , R 2 , R 3 , and R 4 is, individually, hydrogen, Cl, or F, wherein at least one of R 1 , R 2 , R 3 , and R 4 is Cl or F; R 5 is C 1-4 aliphatic, CH(R 5a ) 2 , O—C 1-4 aliphatic, CH 2 —O—C 1-3 aliphatic, O—(CH 2 ) 2 —O—C 1-3 aliphatic, or O—CH 2 C(R 5a ) 3 , wherein each R 5a is, independently, hydrogen, or C 1-3 aliphatic, or two R 5a together with the intervening carbon atom forms a 3-6 membered carbocyclic ring or a 5-6 membered heterocyclic ring having 1-2 oxygen atoms; R 6 is wherein each of m and n is, individually, 1 or 2, and each of R 6a and R 6b is, individually, hydrogen or a C 1-4 aliphatic, or two R 6a or two R 6b groups together with the carbon to which they are bonded form a cyclopropyl ring, and wherein one R 6a together with one R 6b optionally form a 5 or 6-membered ring via a bond or an C 1-2 alkylidene linkage; R 7 is a C 1-4 aliphatic, O—C 1-4 aliphatic, C 1-4 aliphatic-O—C 1-4 aliphatic, or R 6 and R 7 together with the thiophene ring to which they are bonded form the following structure: wherein each of R 7a , R 7b , R 7c , and R 7d is, individually, hydrogen or a C 1-4 aliphatic, or two R 7a , R 7b , R 7c , or R 7d groups together with the intervening atom form a cyclopropyl ring; each of p and q is, individually, 0, 1, or 2; and R 8 is hydrogen, CH 3 or CF 3 .