Patent ID: 7943627

Claim:
A compound of formula I wherein X is ═CR 0 — or ═N—; each of R 0 , R 1 , R 2 and R 4 independently is hydrogen; hydroxy; C 1 -C 8 alkyl; C 2 -C 8 alkenyl; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkyl-C 1 -C 8 alkyl; hydroxyC 1 -C 8 alkyl; C 1 -C 8 alkoxyC 1 -C 8 alkyl; hydroxyC 1 -C 8 alkoxyC 1 -C 8 alkyl; arylC 1 -C 8 alkyl which optionally may be substituted on the ring by hydroxy, C 1 -C 8 alkoxy, carboxy or C 1 -C 8 alkoxycarbonyl; or each of R 1 and R 2 , independently, is halogen; halo-C 1 -C 8 alkyl; C 1 -C 8 alkoxy; halo-C 1 -C 8 alkoxy; hydroxyC 1 -C 8 alkoxy; C 1 -C 8 alkoxyC 1 -C 8 alkoxy; aryl; arylC 1 -C 8 alkoxy; heteroaryl; heteroaryl-C 1 -C 4 alkyl; 5 to 10 membered heterocyclic ring; nitro; carboxy; C 2 -C 8 alkoxycarbonyl; C 2 -C 8 alkylcarbonyl; —N(C 1 -C 8 alkyl)C(O)C 1 -C 8 alkyl; —N(R 10 )R 11 ; —CON(R 10 )R 11 ; —SO 2 N(R 10 )R 11 ; or —C 1 -C 4 -alkylene-SO 2 N(R 10 )R 11 ; wherein each of R 10 and R 11 independently is hydrogen; hydroxy; C 1 -C 8 alkyl; C 2 -C 8 alkenyl; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkyl-C 1 -C 8 alkyl; C 1 -C 8 alkoxyC 1 -C 8 alkyl; hydroxyC 1 -C 8 alkoxyC 1 -C 8 alkyl; hydroxyC 1 -C 8 alkyl; (C 1 -C 8 alkyl)-carbonyl; arylC 1 -C 8 alkyl which optionally may be substituted on the ring by hydroxy, C 1 -C 8 alkoxy, carboxy or C 2 -C 8 alkoxycarbonyl; or 5 to 10 membered heterocyclic ring; or R 1 and R 2 form together with the C-atoms to which they are attached aryl or a 5 to 10 membered heteroaryl group having one or two heteroatoms selected from N, O and S; or R 5 is hydrogen; halogen; cyano; C 1 -C 8 alkyl; halo-C 1 -C 8 alkyl; C 2 -C 8 alkenyl; C 2 -C 8 alkynyl; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkylC 1 -C 8 alkyl; C 5 -C 10 arylC 1 -C 8 alkyl; R 6 is hydrogen; each of R 7 , R 8 and R 9 is independently hydrogen; hydroxy; C 1 -C 8 alkyl; C 2 -C 8 alkenyl; halo-C 1 -C 8 alkyl; C 1 -C 8 alkoxy; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkylC 1 -C 8 alkyl; arylC 1 -C 8 alkyl; —Y—R 12 wherein Y is a direct bond or O and R 12 is a substituted or unsubstituted 5, 6 or 7 membered heterocyclic ring comprising 1, 2 or 3 heteroatoms selected from N, O and S; carboxy; (C 1 -C 8 alkoxy)-carbonyl; —N(C 1-8 alkyl)-CO—NR 10 R 11 ; CONR 10 R 11 ; —N(R 10 )(R 11 ); or R 7 and R 8 or R 8 and R 9 , respectively form together with the carbon atoms to which they are attached, a 5 or 6 membered heteroaryl comprising 1, 2 or 3 heteroatoms selected from N, O and S; or a 5 or 6 membered carbocyclic ring; R 3 is —SO 2 N(R 10 )R 11 ; in free form or salt form; wherein aryl represents phenyl, naphthyl or 1,2,3,4-tetrahydronaphthyl, heteroaryl is a 5 or 6 membered aromatic heterocyclic ring, optionally condensed to 1 or 2 benzene rings and/or to a further heterocylic ring, and wherein a heterocyclic ring is a 5 or 6 membered heterocyclic ring being saturated or unsaturated and optionally condensed to 1 or 2 benzene rings and/or to a further heterocyclic ring.