Patent ID: 8519152

Claim:
A process for the preparation of the compound of formula I which process comprises a) reacting a compound of formula II wherein X is chloro or bromo, with an organometallic species in an inert atmosphere to a halobenzyne of formula X wherein X is chloro or bromo; reacting the halobenzyne of formula X so formed with cyclopentadiene to a compound of formula III wherein X is chloro or bromo; b) reacting the compound of formula III in the presence of an inert solvent with an oxidant to the compound of formula IV wherein X is chloro or bromo; c) reacting the compound of formula IV in the presence of a Lewis acid and a hydride source to the compound of formula V wherein X is chloro or bromo; d) reacting the compound of formula V in the presence of an oxidizing agent, a base and an inert solvent to the compound of formula VI wherein X is chloro or bromo; e) converting the compound of formula VI in the presence of a phosphane and CCl 4 or CHCl 3 to the compound of formula VII wherein X is chloro or bromo; and either f1) reacting the compound of formula VII with NH 3 in the presence of a catalyst comprising palladium and at least one ligand to the compound of formula VIII and g) reacting the compound of formula VIII in the presence of a base with a compound of formula IX to the compound of formula I; or f2) reacting the compound of formula VII wherein X is chloro or bromo; in the presence of a solvent, a base, a copper catalyst and at least one ligand with the compound of formula IXa to the compound of formula I.