Patent ID: 7482349

Claim:
A compound of formula I wherein W is CO; X is N, NO or CR 10 ; Y is N, NO or CR 11 ; Z is N, NO or CR 19 with the proviso that no more than two of X, Y or Z may be N or NO; R 1 and R 2 are each independently H, COR 20 , CO 2 R 21 or an optionally substituted C 1 -C 4 alkyl group; R 3 is H, OR 12 or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl or aryl(C 1 -C 6 )alkyl group each optionally substituted; R 4 and R 5 are each independently H, halogen, NO 2 , CN, OR 13 , NR 14 R 15 or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 3 -C 8 cycloalkyl group each optionally substituted or when attached to adjacent carbon atoms R 4 and R 5 may be taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing one or two heteroatoms selected from O, N or S; R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and R 19 are each independently H, halogen, NO 2 , CN, OR 16 , NR 17 R 18 or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 3 -C 8 cycloalkyl group each optionally substituted; n is 0 or 1; is a single bond when n is 0 or a double bond when n is 1; R 12 , R 13 , R 16 , R 20 and R 21 are each independently H or a C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl or aryl group each optionally substituted; and R 14 , R 15 , R 17 and R 18 are each independently H or C 1 -C 4 alkyl; or a tautomer thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof.