Patent ID: 8585971

Claim:
A system to manipulate particles in a fluid, the system comprising: a first channel through which particles and magnetic beads in a fluid are flowed, wherein a portion of the particles bind to the magnetic beads; and a device to manipulate the particles and the magnetic beads, the device comprising: a second channel extending from one or more inlets to one or more outlets, wherein the second channel is bounded by a first wall, and a second wall located opposite from the first wall; a first array of obstacles disposed within the second channel and bounded by the first wall and a first array boundary; a second array of obstacles disposed within the second channel and bounded by the second wall and a second array boundary, and a bypass channel defined by a region within the second channel devoid of obstacles between the first array boundary and the second array boundary, wherein the first array and the second array are configured to deflect the portion of the particles that bind to the magnetic beads in the fluid flowed through the first array and the second array, respectively, toward the bypass channel.