Patent ID: 8288354

Claim:
A method of treating a disease or condition in a subject in need of treatment thereof by modulating expression of a targeted gene encoding a drug target in a target cell, comprising: targeting a nucleic acid molecule to a naturally-occurring anti-sense transcript of a sense strand of the targeted gene in the target cell, wherein the nucleic acid molecule targeting the anti-sense transcript is complementary to the anti-sense transcript; and, wherein the anti-sense transcript is a coding RNA transcript or a noncoding RNA transcript lacking any extensive open reading frame, wherein the targeted gene is selected from the group consisting of CD97, TS-Î±, C/EBP delta, CDC23, PINK1, HIF1Î±, Gnbp3g, Adrenomedullin AM1 receptor, 3-oxoacid CoA transferase, Cathepsin W and BACE1, whereby expression of the sense strand in the target cell is modulated and expression of the gene encoding the drug target is up-regulated or down-regulated.