Patent ID: 8822462

Claim:
A compound having the following formula: wherein X is, independently, N or C bonded to H or a substituent, J, with the proviso that no more than one of X are N; Y is O; R 1 and R 2 are independently selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and hydroxy, R 1 and R 2 can optionally join to form a C 3-10 heterocyclic moiety, which heterocyclic moiety can optionally include a second heteroatom selected from O, S, and N, z is an integer from 0 to 3, and J is a non-hydrogen substituent selected from the group consisting of halo (—F, —Cl, —Br, —I), amino (NR 1 R 2 ), OR 1 , SR 1 , —R 1 , —CF 3 , —CN, —C 2 R 1 , —SO 2 CH 3 , —C(═O)NR 1 R 2 —NR′C(═O)R 1 , —C(═O)R 1 , —C(═O)OR 1 , —(CH 2 ) q OR 1 , —OC(═O)R 1 , —OC(═O)NR 1 R 2 , —NR 1 (C═Y)—NR 1 R 2 , —NR 1 (C═Y)—OH, —NR 1 (C═Y)—SH, sulfonyl, sulfinyl, phosphoryl, and azo, wherein a substituted alkyl, substituted alkenyl, substituted aryl, or substituted heteroaryl is alkyl, alkenyl, aryl, or heteroaryl substituted with one or more substituent, wherein a substituent is fluoro, chloro, bromo, iodo, hydroxy, heterocyclic, heteroaryl, carboxy, alkoxy, NH 2 , N(alkyl) 2 , NH(alkyl), alkoxycarbonyl, —N(H or alkyl)C(O)(H or alkyl), —N(H or alkyl)C(O)N(H or alkyl) 2 , —N(H or alkyl)C(O)O(H or alkyl), —OC(O)N(H or alkyl) 2 , —S(O) n —(H or alkyl), —C(O)—N(H or alkyl) 2 , cyano, alkenyl, cycloalkyl, acyl, hydroxyalkyl, heterocyclic, heteroaryl, aryl, aminoalkyl, oxo, carboxyalkyl, —C(O)—NH 2 , —C(O)—N(H)O(H or alkyl), —S(O) 2 —NH 2 , —S(O) n —N(H or alkyl) 2 and/or —S(O) 2 —N(H or alkyl) 2 wherein the dashed line is an optional double bond, and pharmaceutically acceptable salts, or esters thereof.