Patent ID: 6872743

Claim:
A tetracyclic compound represented by the formula (I), or a pharmaceutically acceptable salt, or solvate thereof; wherein A is C; n is 1, 2 or 3; B, C, D, and E are ring identifiers; the ring B has 0 to 3 double bonds depending on ring size; R 1 is selected from groups (a), or (b) wherein; (a) is C 7 -C 20 alkyl, C 7 -C 20 haloalkyl, C 7 -C 20 alkenyl, or C 7 -C 20 alkynyl; (b) is a member of (a) substituted with one or more substituents independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 7 -C 12 aralkyl, C 7 -C 12 alkaryl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, phenyl, toluyl, xylenyl, biphenyl, C 1 -C 8 alkoxy, C 2 -C 8 alkenyloxy, C 2 -C 8 alkynyloxy, C 2 -C 12 alkoxyalkyl, C 2 -C 12 alkoxyalkyloxy, C 2 -C 12 alkylcarbonyl; R 2 , R 3 and R 4 are each independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 7 -C 12 aralkyl, C 7 -C 12 alkaryl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, phenyl, toluyl, xylenyl, biphenyl, C 1 -C 8 alkoxy, C 2 -C 8 alkenyloxy, C 2 -C 8 alkynyloxy, C 2 -C 12 alkoxyalkyl, C 2 -C 12 alkoxyalkyloxy, C 1 -C 8 haloalkyl, nitro, and cyano; R 5 is -(L 5 )-Z, where -(L 5 )- is a bond, or —(CH 2 )—; and Z is selected from an amide, thioamide, oxime amide, oxime thioamide, glyoxylamide, hydrazide, or acetamide group represented by the formulae,