Patent ID: 8642555

Claim:
A prodrug having the following formula I: R-A n -Ser-Leu-Y—Z (I) wherein R=a protein binding moiety comprising a maleimide group and a C 1-10 acyl group; A=a peptide sequence consisting of L- and/or D-amino acids, wherein the amino acid residues may be the same or different; n=an integer from 1 to 10, indicating the number of amino acids in the peptide sequence; Y=p-aminobenzyloxycarbonyl (PABC); and Z=a cytostatic agent; wherein the peptide sequence is selected from the group consisting of Arg-Ser-Ser-Tyr-Tyr (SEQ ID NO. 1), Arg-Ser-Ser-Tyr-Ser (SEQ ID NO. 2), Arg-Ser-Ser-Tyr-Arg (SEQ ID NO. 3), Ser-Ser-Tyr-Arg (SEQ ID NO. 4), Ser-Ser-Tyr-Tyr (SEQ ID NO. 5), Arg-Arg-Leu-His-Tyr (SEQ ID NO. 6), Arg-Arg-Leu-Asn-Tyr (SEQ ID NO. 7), Ser-Ser-Lys-Leu-Gln (SEQ ID NO. 8) and Arg-Ala-Ser-Tyr-Gln (SEQ ID NO. 9).