Patent ID: 8367065

Claim:
A compound of the Formula (I) wherein: R 1 is a polyalkylene oxide; A is a capping group or each D 1 is independently selected from the group consisting of targeting moieties, functional groups and leaving groups; each D 2 is independently selected from the group consisting of biologically active moieties, functional groups and leaving groups; each L 1 is an independently selected permanent linker selected from the group consisting of: L 2 is a multifunctional linker is selected from the group consisting of: wherein R 2 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-19 branched alkyl, C 3 -8 cycloalkyl, C 1-6 substituted alkyl, C 2-6 substituted alkenyl, C 2-6 substituted alkynyl, C 3-8 substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C 1-6 heteroalkyl, substituted C 1-6 heteroalkyl, C 1-6 alkoxy, aryloxy, C 1-6 heteroalkoxy, heteroaryloxy, C 2-6 alkanoyl, arylcarbonyl, C 2-6 alkoxycarbonyl, aryloxycarbonyl, C 2-6 alkanoyloxy, arylcarbonyloxy, C 2-6 substituted alkanoyl, substituted arylcarbonyl, C 2-6 substituted alkanoyloxy, substituted aryloxycarbonyl, C 2-6 substituted alkanoyloxy and substituted arylcarbonyloxy; each L 3 is an independently selected permanent linker or a releasable linker, wherein the releasable linker is selected from the group consisting of: -Val-Cit-, -Gly-Phe-Leu-Gly-, -Ala-Leu-Ala-Leu- -Phe-Lys-, -Val-Cit-C(═O)—CH 2 OCH 2 —C(═O)—, -Val-Cit-C(═O)—CH 2 SCH 2 —C(═O)—, and —NHCH(CH 3 )—C(═O)—NH(CH 2 ) 6 —C(CH 3 ) 2 —C(═O)—, wherein Y 11-19 are independently O, S or NR 48 ; R 31-48 , R 50 , R 100 and A 51 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cyloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, C 1-6 alkyloxycarbonyl, phenoxy and C 1-6 heteroalkoxy; Ar is an aryl or heteroaryl moiety; L 11-15 are independently selected bifunctional spacers; Z and Z′ are independently selected from selected from the group consisting of moieties actively transported into a target cell, hydrophobic moieties, bifunctional linking moieties and combinations thereof; (c11), (h11), (k11), (l11), (m11) and (n11) are one; (a11), (e11), (g11), (j11), (o11) and (q11) are independently either zero or one; and (b11), (x11), (x′12), (f11), (i11) and (p11) are independently zero or one; and (a) and (b) are independently zero or one.