Patent ID: 8618114

Claim:
A compound of the general formula 1, or a pharmaceutically acceptable salt thereof, wherein: X=S, SO, NH; R 1 is hydrogen, â€”CH 3 , â€”CH 2 OH, an optionally substituted C 2 -C 3 alkyl, cycloalkyl, adamantyl, optionally substituted aryl or 5-6 membered optionally annelated heterocyclyl, in which a heteroatom is selected from nitrogen or oxygen, alkoxycarbonyl, carboxyl, amide group; R 2 is hydrogen, halogen, optionally substituted C 1 -C 3 alkyl, substituted hydroxyl, substituted amino group or â€”(CH 2 ) n Z group; R 3 , wherein X=NH, is hydrogen, optionally substituted C 1 -C 3 alkyl, substituted hydroxyl, optionally mono- or disubstituted amino group or saturated 6-membered azaheterocyclyl containing an additional heteroatom selected from nitrogen or oxygen; pyridyl, alkoxycarbonyl, carboxyl or amide group; or R 3 , wherein X=S, SO, is hydrogen, optionally substituted C 1 -C 3 alkyl, substituted hydroxyl, pyridyl, alkoxycarbonyl, carboxyl or amide group; or R 1 and R 3 independently are different substituents selected from C 1 -C 3 alkyl, or â€”(CH 2 ) n Z group, and R 2 is hydrogen, halogen, optionally substituted C 1 -C 3 alkyl, substituted hydroxyl; R 4 is C 1 -C 3 alkyl; R 5 is hydrogen, one or two halogens, C 1 -C 3 alkyl or optionally substituted hydroxyl; n is 0, 1, 2 or 3; Z, wherein X=NH, is carboxyl COOH, C 1 -C 3 alkyloxycarbonyl substituted amide group CONR 10 R 11 or amino group NR 10 R 11 ; R 10 and R 11 are optionally identical hydrogen, optionally substituted C 1 -C 3 alkyl, C 3 -C 7 cycloalkyl or optionally substituted 5-7-membered azaheterocyclyl containing 1-2 nitrogen atoms in the cycle, wherein the substituents are selected from C 1 -C 3 alkyl; or R 10 and R 11 together with the nitrogen atom to which they are attached form an optionally substituted 5-6-membered azaheterocyclyl containing 1-2 nitrogen atoms in the cycle, wherein the substituent is selected from C 1 -C 3 alkyl; or Z, wherein X=S, SO, is carboxyl COOH, C 1 -C 3 alkyloxycarbonyl substituted amide group CONR 10 R 11 or amino group NR 10 R 11 ; R 10 and R 11 are optionally identical hydrogen, optionally substituted C 1 -C 5 alkyl; or R 10 and R 11 together with the nitrogen atom to which they are attached form an optionally substituted 6-membered azaheterocyclyl containing 1-2 nitrogen atoms in the cycle, wherein the substituent is selected C 1 -C 3 alkyl; with the exception of the compounds wherein X=S, R 3 is â€”(CH 2 ) n Z group, wherein Z is amino group NR 10 R 11 and n=0.