Patent ID: 7025987

Claim:
An α v β 3 integrin receptor targeting liposome comprising a cationic amphiphile; a neutral lipid; a targeting lipid having a non-peptidic a α v β 3 integrin antagonist and a hydrophobic domain bound to the antagonist; and a nucleic acid complexed with the cationic amphiphile; the cationic amphiphile being present in an amount in the range of about 1 to about 50 mole percent, and said targeting lipid being present on the surface of the liposome in an amount in the range of about 1 to about 20 mole percent, the mole percent values being based on total moles of lipid in the liposome, and the non-peptidic α v β 3 integrin antagonist comprising a nitrogen-containing cationic ring structure and a carboxyl-containing anionic structure wherein said structures are spaced from one another by a spacer group that provides a spacing between each of the structures in the range of about 10 Angstroms to about 100 Angstroms at physiologic pH values.