Patent ID: 8642089

Claim:
A process for the production of active ingredient-containing granules or powders comprising: a) melting of a mixture consisting essentially of a pharmaceutical active ingredient and a (meth)-acrylate copolymer which consists of 40 to 75% by weight of free radical-polymerized C 1 - to C 4 -alkyl esters of acrylic or of methacrylic acid and 25 to 60% by weight of (meth)acrylate monomers having an anionic group in the alkyl radical; b) extruding the mixture to obtain an extrudate; and c) comminuting the extrudate to give granules or powder; wherein a processing temperature of steps a) and b) is 10-50° C. above the glass transition temperature (T mg ) of the (meth)acrylate copolymer, wherein T mg is determined without plasticizer addition and in accordance with ISO 11357-2, item 3.3.3; the active ingredient is the salt of a basic substance; and the powder or granules obtained have a pH 7.0 or less.