Patent ID: 8658711

Claim:
A method of synthesizing a methacrylate-derivatized type-I collagen, comprising: (a) reacting methacrylic acid with a carboxylic acid activating reagent in the presence of a carbodiimide to form a methacrylic acid with an activated carboxylic acid group; and (b) reacting free amino groups on a type-I collagen with the activated carboxylic acid groups on said methacrylic acid to form a collagen methacrylamide; (c) removing excess reagents from said collagen methacrylamide; (d) reacting free carboxylic acid groups on said collagen methacrylamide with a carboxylic acid activating reagent in the presence of a carbodiimide to form a collagen methacrylamide with activated carboxylic acid groups; and (e) reacting said activated carboxylic acid groups on said collagen methacrylamide with aminoethylmethacrylate in the presence of a carbodiimide to form a collagen methacrylamide amidoethylmethacrylate.