Patent ID: 8188068

Claim:
A chemical compound, comprising: a bridged polycyclic compound comprising a structure (Ib): wherein Z comprises at least one bridge, wherein at least one of the bridges is —R 2 —N + R 3 2 —R 4 —N + R 3 2 —R 2 —, —R 2 —NR 3 —R 4 —N + R 3 2 —R 2 —, or —R 2 —NR 3 —R 4 —NR 3 —R 2 —, and wherein each bridge independently couples R 1 to R 1 ; wherein each R 1 is independently N, N + H, or N + R 3 ; wherein each R 2 is independently an alkyl group, a substituted alkyl group, or an alkene; wherein each R 3 is independently a pharmaceutically active agent, a hydrogen, an ester, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocycle group, a substituted heterocycle group, an alkene, an ether, a guanidine derivative, a polyethyleneglycol, a polyethyleneimine, or any combination of these, and wherein at least two R 3 s are a pharmaceutically active agent comprising a guanidine or a guanidine derivative; wherein each R 4 is independently an aryl group or a substituted aryl group; wherein each of the heterocycle groups independently comprises a 5-7-membered monocyclic ring or a 7-10-membered bicyclic heterocyclic ring, and wherein the heterocycle group comprises carbon atoms and 1-4 heteroatoms; wherein each of the substituted heterocycle groups independently comprises at least one substituent and wherein each substituent is independently an alkyl, an aryl, an acyl, a halogen, an alkylhalo, a hydroxy, an amino, an alkoxy, an alkylamino, an acylamino, an acyloxy, an aryloxy, an aryloxyalkyl, a thioether, a heterocycle, a saturated cyclic hydrocarbon, and/or an unsaturated cyclic hydrocarbon; wherein each of the substituted alkyls independently group comprises at least one substituent and wherein each substituent is independently an aryl, an acyl, an alkyl, a halogen, an alkylhalo, a hydroxy, an amino, an alkoxy, an alkylamino, an acylamino, an acyloxy, an aryloxy, an aryloxyalkyl, a mercapto, a saturated cyclic hydrocarbon, an unsaturated cyclic hydrocarbon, and/or a heterocycle; wherein when R 4 is an aryl group the aryl group is a phenyl, a naphthyl, a biphenyl, a diphenylmethyl, or a benzophenone; and wherein when R 4 is a substituted aryl group the substituted aryl group is a phenyl having at least one substituent, a naphthyl having at least one substituent, a biphenyl having at least one substituent, a diphenylmethyl having at least one substituent, or a benzophenone having at least one substituent.