Patent ID: 7576121

Claim:
A pyrrolidine compound represented by formula I: a cyclic isomer thereof wherein the cyclic isomer is a compound of formula (V): wherein the asymmetric carbons C a and C b independently have an R configuration, an S configuration, or a mixture of both configurations such that all stereoisomers and all stereomeric mixtures are included, any pharmaceutically acceptable salt thereof, or any prodrug thereof; wherein, R 1 is a substituted or unsubstituted (C 3-8 ) alkyl, alkenyl, aralkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocyclyl, or heterocyclylalkyl group; R 2 and R 3 , independently or together, are —OH, —O − M + wherein M + is a cation, a hydroxyl bearing a boronic acid protecting group, or a group capable of being hydrolyzed to a hydroxyl group in an aqueous solution at physiological pH or in biological fluids; and the wavy lines at asymmetric carbons C a and C b independently indicate for each asymmetric carbon an R configuration, an S configuration, or a mixture of both configurations such that all stereoisomers and all stereomeric mixtures are included.