Patent ID: 7517885

Claim:
A compound of Formula (I) and pharmaceutically acceptable salts, hydrates and stereoisomeric, crystalline and amorphous forms thereof, wherein R 1 and R 2 is each selected from the group consisting of hydrogen and C 1-8 alkyl; R 3 is up to four optionally present substituents independently selected from the group consisting of (1) C 1-8 alkyl, (2) C 1-8 alkoxy, (3) C 1-8 alkyl(C 1-8 alkoxy), (4) C 1-8 alkyl(halogen) 1-17 , (5) C 1-8 alkoxy(halogen) 1-17 , (6) NH 2 , NH(C 1-8 alkyl) or N(C 1-8 alkyl) 2 , (7) halogen, (8) hydroxy, and (9) C 1-8 alkoxy(C 3-8 cycloalkyl); R 4 and R 5 is each hydrogen or is each up to four substituents independently selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy, NH 2 , NH(C 1-8 aklyl), N(C 1-8 alkyl) 2 , cyano, halogen, oxo and nitro; p is an integer selected from 0, 1, 2, 3, 4, 5, 6, 7 or 8; Ar is phenyl; and R 6 , R 7 and R 8 is each hydrogen or is each selected from the group consisting of (1) C 1-8 alkyl, (2) C 1-8 alkoxy, (3) C 1-8 alkyl(C 1-8 alkoxy), (4) C 1-8 alkyl(halogen) 1-17 , (5) C 1-8 alkoxy(halogen) 1-17 , (8) NH 2 , NH(C 1-8 alkyl) or N(C 1-8 alkyl) 2 , (10) halogen, (13) C 1-8 alkyl(NH 2 ), C 1-8 alkyl[NH(C 1-8 alkyl)] or C 1-8 alkyl[N(C 1-8 alkyl) 2 ], (14) C 3-8 cycloalkyl, (15) C 3 cycloalkyloxy, (18) aryl, and (19) aryloxy.