Patent ID: 7696203

Claim:
A compound of formula (I): and isomers, salts, chemically protected forms, or prodrugs thereof, wherein, A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; R N1 and R N2 are independently selected from hydrogen, an optionally substituted C 1-7 alkyl group, C 3-20 heterocyclyl group, or C 5-20 aryl group, or together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if A, B, D are selected from groups (i), (ii) above, then Z is selected from the group consisting of S, O, C(═O), CH 2 and NH; and if A, B, D represent group (iii), then Z is selected from the group consisting of O, C(═O), CH 2 and NH; R 4 is selected from the group consisting of H, OH, NO 2 , NH 2 and Q—Y—X where Q is —NH—C(═O)— or —O—; Y is an optionally substituted C 1-15 alkylene group; X is selected from SR S1 or NR N3 R N4 , wherein, R S1 , or R N3 and R N4 are independently selected from hydrogen, optionally substituted C 1-7 alkyl, C 5-20 aryl, or C 3-20 heterocyclyl groups, or R N3 and R N4 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, then X may additionally be selected from —C(═O)—NR N5 R N6 , wherein R N5 and R N6 are independently selected from hydrogen, optionally substituted C 1-7 alkyl, C 5-20 aryl, or C 3-20 heterocyclyl groups, or R N5 and R N6 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms and if Q is —NH—C(═O)—, then —Y—X may additionally be selected from C 1-7 alkyl; with the proviso that if A, B, D represent group (iii) and R N1 and R N2 together with the carbon atom to which they are bound form a morpholino group, R 4 cannot be H.