Patent ID: 7919264

Claim:
A method for determining the efficacy of a human anti-TNFα antibody, or an antigen-binding portion thereof, for treating a subject having ankylosing spondylitis (AS), said method comprising determining a level of a collagen degradation biomarker and a synovitis biomarker in a sample(s) obtained from the subject following administration of the human anti-TNFα antibody, or an antigen-binding portion thereof; and comparing the level of the collagen degradation biomarker and the synovitis biomarker in the sample(s) obtained from the subject with a known standard level of the collagen degradation biomarker and the synovitis biomarker associated with AS, wherein a lower level of the collagen degradation biomarker and the synovitis biomarker in the sample(s) from the subject relative to the known standard level of the collagen degradation biomarker and the synovitis biomarker indicates that the human anti-TNFα antibody, or an antigen-binding portion thereof, is efficacious for the treatment of AS in the subject.