Patent ID: 7358334

Claim:
A multi-component B-cell specific clonal toxin composition comprising: a first fusion molecule comprising a first targeting domain and an enzymatically active type I or type II ribosome inactivating polypeptide or active subunit thereof; and a second fusion molecule comprising a second targeting domain and a toxin translocation domain that is capable of interacting with and translocating the enzymatically active type I or type II ribosome inactivating polypeptide or active subunit thereof to the cytosol in a target B-cell, wherein the first fusion molecule is delivered to the cytosol only in the presence of the second fusion molecule, wherein the enzymatically active type I or type II ribosome inactivating polypeptide or active subunit thereof and the toxin translocation domain are not from the same native protein toxin and wherein the first and the second targeting domains bind to different receptors on the target B-cell.