Patent ID: 8216609

Claim:
A modified release dosage form comprising of a high solubility active ingredient wherein the high solubility active ingredient has a solubility where less than 1part to 30 parts of water is required to dissolve 1 part of active ingredient and said modified release dosage form is prepared by using a dual retard technique to control the release of the high solubility active ingredient, wherein said dual retard technique is a combination of matrix formulation and reservoir formulation said dosage form comprising a) micro matrix particles consisting of active ingredient(s) and hydrophobic release controlling agent wherein one or more hydrophobic release controlling agents are selected from the group consisting of ammonio methacrylate copolymers type A and B, methacrylic acid copolymer type A, B and C, poly(methyl methacrylate), poly(ethyl methacrylate), poly(butyl methacrylate), poly(isobutyl methacrylate), poly(hexyl methacrylate), poly(isodecyl methacrylate), poly lauryl methacrylate), poly (phenyl methacrylate), poly(methyl acrylate), poly(isopropyl acrylate), poly(isobutyl acrylate), poly(octadecyl acrylate), beeswax, carnauba wax, microcrystalline wax, ozokerite; cetostearyl alcohol, stearyl alcohol; cetyl alcohol myristyl alcohol; glyceryl monostearate glycerol distearate; glycerol monooleate, acetylated monoglycerides, tristearin, tripalmitin, cetyl esters wax, glyceryl palmitostearate, glyceryl behenate hydrogenated castor oil and b)a coating of one or more of said hydrophobic release controlling agents on said micro matrix particles wherein the dosage form reduces the chances of burst effects.