Patent ID: 8198429

Claim:
A composition, comprising a first and a second antisense oligonucleotide, wherein each oligonucleotide is composed of morpholino subunits linked by phosphorous-containing intersubunit linkages which join a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit in accordance with the structure: wherein Y 1 ═O, Z═O, Pj is a purine or pyrimidine base-pairing moiety effective to bind, by base-specific hydrogen bonding, to a base in a polynucleotide, and X is —N(CH 3 ) 2 or 1-piperazino, wherein the first oligonucleotide is targeted against Marburg virus NP and consists of the sequence set forth in SEQ ID NO:79, and wherein the second oligonucleotide is targeted against Marburg virus VP24 and consists of the sequence set forth in SEQ ID NO:80.