Patent ID: 7384934

Claim:
A compound of formula (I): wherein: is Alk is (C 1-4 ) alkylene or hydroxy substituted (C 1-4 ) alkylene; X is oxygen or sulfur; R 1 is (C 1-6 ) fluoroalkyl, (C 3-6 ) cycloalkyl, or (C 1-4 ) alkyl, wherein the (C 1-4 ) alkyl is unsubstituted or substituted with hydroxy, methoxy, ethoxy, OCH 2 CH 2 OH, or —CN; R 2 is H, halogen, (C 1-6 )fluoroalkyl, (C 3-6 ) cycloalkyl, OR 4 , SR 4 , NO 2 , CN, COR 4 , C(O)OR 4 , CONR 5 R 6 , NR 5 R 6 , SO 2 NR 5 R 6 , NR 5 COR 4 , NR 5 SO 2 R 4 , optionally substituted aromatic, or (C 1-6 ) alkyl, wherein the (C 1-6 ) alkyl is unsubstituted or substituted with hydroxy; R 3 is hydrogen, (C 1-4 ) alkyl, (C 3-6 ) cycloalkyl, (C 2-6 ) alkenyl, Ar, or (C 1-4 )alkyl-Ar; R 4 is hydrogen, (C 1-6 ) alkyl, (C 1-6 ) fluoroalkyl, or optionally substituted aromatic; R 5 and R 6 are independently hydrogen, (C 1-6 ) alkyl, or optionally substituted aromatic, R 7 is hydrogen, (C 1-6 ) alkyl, (C 1-6 ) fluoroalkyl, or optionally substituted aromatic; R 8 and R 9 are independently hydrogen, (C 1-6 ) alkyl, or optionally substituted aromatic; Ar is optionally substituted phenyl, napthyl, monocyclic heteroaromatic or bicyclic heteroaromatic; Z 1 and Z 2 are independently selected from hydrogen, halogen, (C 1-6 ) alkyl, (C 1-6 ) fluoroalkyl, OR 7 , SR 7 , NO 2 , CN, COR 7 , CONR 8 R 9 , NR 8 R 9 , and optionally substituted aromatic; or a pharmaceutically acceptable salt or hydrate thereof.