Patent ID: 8216569

Claim:
A method of treating or ameliorating cancer or tumor mediated by human VEGF-2, comprising administering to a human an isolated antibody or antigen binding fragment thereof that specifically binds to a human VEGF-2 polypeptide, said antibody comprising: (i) an amino acid sequence that is at least 96% identical to the amino acid sequence of the VH domain of the antibody expressed by the hybridoma cell line deposited under ATCC Deposit No. PTA-4095, wherein the amino acid sequence comprises the amino acid sequences of the VHCDR1, VHCDR2, and VHCDR3 regions of the antibody expressed by the hybridoma deposited under ATCC Deposit No. PTA-4095; and (ii) an amino acid sequence that is at least 96% identical to the amino acid sequence of the VL domain of the antibody expressed by the hybridoma cell line deposited under ATCC Deposit No. PTA-4095, wherein the amino acid sequence comprises the amino acid sequences of the VLCDR1, VLCDR2, and VLCDR3 regions of the antibody expressed by the hybridoma deposited under ATCC Deposit No. PTA-4095.