Patent ID: 7507568

Claim:
A method of identifying a drug candidate compound for the treatment of an angiogenic mediate disorder, comprising: a) employing the three-dimensional structural coordinates of the human protein tyrosine phosphatase beta (HPTPbeta) catalytic domain [SEQ ID NO:7] as set forth in FIGS. 202-252 to graphically image the HPTPbeta catalytic domain [SEQ ID NO: 7], and determining the binding mode of a compound within the catalytic domain; b) selecting one or more compounds which have the best fit with the HPTPbeta catalytic domain [SEQ ID NO:7] as a set forth in FIGS. 202-252 wherein the compounds are computationally positioned at one or more areas of said imaged HPTPbeta catalytic domain [SEQ ID NO:7] and c) assaying analyzing the ability of said drug candidate compound to bind or modulate HPTPbeta activity.