Patent ID: 7658929

Claim:
A method for diagnosing an infection in a patient likely to be infected with a pathogenic microorganism, comprising the detection of CD4+ T lymphocytes recognizing a least one glycopeptide selected from the group consisting of: a1) a glycopeptide essentially consisting of a glycosylated T epitope, comprising a 14 to 25 amino acid sequence which is present in the sequence of a glycoprotein from said pathogenic microorganism and in which at least one neutral amino acid is bonded to a disaccharide or to a trisaccharide, and at least 15% of said amino acids are prolines, one of the prolines being located in position −1 to −4, relative to the position of said neutral amino acid, which glycopeptide is: presented by a class II MHC molecule, specifically recognized by CD4+ T lymphocytes induced by immunization with the native glycoprotein from which said glycopeptide is derived, said glycopeptide is not recognized by the CD4+ T lymphocytes induced by immunization with a non-glycosylated peptide with the same sequence, and capable of inducing a proliferation of said CD4+ T lymphocytes which recognize said glycopeptide and the secretion of cytokines by said lymphocytes, and b1) a glycopeptide having a sequence of 15 to 39 amino acids which includes the sequence of the glycopeptide as defined in a1).