Patent ID: 8580948

Claim:
A compound comprising a modified oligonucleotide consisting of 8 to 80 linked nucleosides and having a nucleobase sequence with at least 80% complementarity to a nucleic acid molecule encoding forkhead box O1A (SEQ ID NO: 4) and comprising at least 8 contiguous nucleobases of a nucleobase sequence recited in any one of SEQ ID NOs: 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 32, 33, 34, 35, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 51, 52, 54, 86, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 173, 174, 175, and 176, wherein the modified oligonucleotide comprises at least one modification selected from a modified internucleoside linkage, a modified sugar, and a modified nucleobase.