Patent ID: 7494984

Claim:
A compound of Formula I wherein: R 1 is (Ar 1 )alkyl; R 2 is hydrogen, hydroxy, alkyl, or alkoxy; R 3 is hydrogen, halo, hydroxy, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, C 4-6 lactamyl, N(R 6 )SO 2 R 7 , N(R 6 )COR 7 , N(R 6 )CO 2 R 7 , OCOR 7 , OCO 2 R 7 , OCON(R 6 )(R 6 ), COR 7 , CO 2 R 6 , CON(R 6 )(R 6 ), SOR 7 , SO 2 R 7 , SO 2 N(R 6 )(R 6 ), P(O)(OR 6 ) 2 , or Ar 2 ; R 4 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, or haloalkoxy; R 5 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, or haloalkoxy; R 6 is hydrogen, alkyl, or cycloalkyl; R 7 is alkyl or cycloalkyl; R 8 is hydrogen or alkyl; R 9 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, (alkoxy)alkyl, phenyl, or benzyl, wherein phenyl and benzyl are substituted with 0-2 substituents selected from the group consisting of halo, cyano, alkyl, alkoxy, halolkyl, and haloalkoxy; Ar 1 is Ar 2 is tetrazolyl, triazolyl, pyrazolyl, imidazolyl, pyrrolyl, or dioxothiazinyl, and is substituted with 0-2 substituents selected from the group consisting of amino, oxo, halo, and alkyl; and X—Y-Z is N(R 9 )C(R 8 ) 2 C(R 8 ) 2 ; or a pharmaceutically acceptable salt thereof.