Patent ID: 8278415

Claim:
A composition comprising a fusion protein according to the formula: V 1 o -Pep a -Flex n - V 2 m -Hinge-CH2-CH3 (I) and wherein Pep represents domains I to III of human EGFR capable of binding EGF with an affinity of less than 1 nM when measured by BIAcore, V1 is the sequence QIQ, Flex is a flexible linker peptide, V2 represents a sequence derived from an immunoglobulin J gene domain and is TLVTVSS (SEQ ID No:61), the hinge, CH2 and CH3 are domains from a human IgG 1 and each of a, m, n and o is equal to 1, wherein the fusion protein comprises SEQ ID NO:2.