Patent ID: 7125844

Claim:
An antimicrobial compound according to structural formula (III): or pharmaceutically acceptable salt thereof, wherein: R 3 is independently selected from hydrogen, (C 1 –C 25 ) alkyl optionally substituted with one or more of the same or different R 15 groups, (C 1 –C 25 ) heteroalkyl optionally substituted with one or more of the same or different R 15 groups, (C 5 –C 10 ) aryl optionally substituted with one or more of the same or different R 15 groups, (C 5 –C 15 ) arylaryl optionally substituted with one or more of the same or different R 15 groups, (C 5 –C 15 ) biaryl optionally substituted with one or more of the same or different R 15 groups, 5–10 membered heteroaryl optionally substituted with one or more of the same or different R 15 groups, (C 6 –C 26 ) arylalkyl optionally substituted with one or more of the same or different R 15 groups, 6–26 membered heteroarylalkyl optionally substituted with one or more of the same or different R 15 groups, and a linear or branched, saturated or singly or multiply unsaturated alkyl or hydroxy alkyl having a chain of 6 to 22 carbon atoms; R 4 is Asp or Asn; R 6 is independently selected from at least one amino acid, a substituent comprising a primary or secondary amine, (C 1 –C 25 ) alkyl optionally substituted with one or more of the same or different R 15 groups, (C 1 –C 25 ) heteroalkyl optionally substituted with one or more of the same or different R 15 groups, (C 5 –C 10 ) aryl optionally substituted with one or more of the same or different R 15 groups, (C 5 –C 15 ) arylaryl optionally substituted with one or more of the same or different R 15 groups, (C 5 –C 15 ) biaryl optionally substituted with one or more of the same or different R 15 groups, 5–10 membered heteroaryl optionally substituted with one or more of the same or different R 15 groups, (C 6 –C 26 ) arylalkyl optionally substituted with one or more of the same or different R 15 groups, and 6–26 membered heteroarylalkyl optionally substituted with one or more of the same or different R 15 groups; each R 15 is independently selected from —OR 16 , —SR 16 , NR 16 R 16 , —CN, —NO 2 , —N 3 , —C(O)OR 16 , —C(O)NR 16 R 16 , —C(S)NR 16 R 16 , —C(NR 16 )NR 16 R 16 , —CHO, —R 16 CO, —SO 2 R 16 , —SOR 16 , —PO(OR 16 ) 2 , —PO(OR 16 ), —CO 2 H, —SO 3 H, —PO 3 H, halogen, and trihalomethyl; and each R 16 is independently selected from hydrogen, (C 1 –C 6 ) alkyl, (C 5 –C 10 ) aryl, 5–10 membered heteroaryl, (C 6 –C 16 ) arylalkyl, and 6–16 membered heteroarylalkyl.