Patent ID: 7381741

Claim:
A compound having the Formulae: or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 and R 2 are each independently H, C 1-6 alkyl or halo; R 3 is phenyl, bi-phenyl, 6-methoxy-3-methyl-1,1a,3,7b-tetrahydro-3-aza-cyclopropa[a]naphthalen-2-one, 6-methoxy-1-methyl-3,4-dihydro-1H-[1,5]naphthyridin-2-one-7-yl, dibenzofuranyl, 6-methoxy-3-methyl-1,1a,3,7b-tetrahydro-3-aza-cyclopropa[a]naphthalen-2-one-5-yl or naphthyl, all of which are substituted with 1 to 3 substituents independently selected from hydroxy, C 3-6 cycloalkoxy, benzo(C 3-6 )cycloalkoxy, C 1-6 alkylthio, tetrazole, or C 6-10 aryloxy, said aryloxy or tetrazole being optionally substituted with 1 to 3 substituents independently selected from halo, C 1-4 alkoxy, cyano, C 1-4 haloalkyl or C 1-4 alkyl; or R 3 is phenyl, to which is fused a C 3-6 cycloalkyl, a C 4-5 lactam, thiazole, pyridone, pyran, dioxolan or benzofuran, wherein the C—N and C-phenyl bonds at the C atoms denoted * are in the cis or trans position relative to each other; R 4 is H or halo; R 5 is H or C 1-6 alkyl; and R 6 is selected from phenyl, indanyl, pyridinyl, benzothiazoyl, thiophenyl, furanyl, quinolinyl, benzothiophenyl, benzofuranyl, isochromanyl, chromanyl, or naphthyl, and R 6 can be optionally substituted with 1 to 3 of the substitutents independently selected from halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, piperidinyl or phenyl; wherein the C—N and C-phenyl bonds at the C atoms denoted * are in the cis or trans position relative to each other, with the provisos that said compound not be cis-3-(2-methoxybenzylamino)-2-phenyl-pyrrolidine, nor 3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpyrrolidine.