Patent ID: 8865408

Claim:
A method for diagnosing aggressiveness of a cancer in a patient from a cancer sample of said patient, comprising: measuring in vitro the expression level of the POLQ gene and/or its isoforms arising from alternative splicing, and the expression level of a control gene in said patient cancer sample, calculating for said POLQ gene and/or isoform an expression level ratio of the expression level of POLQ and/or one or several of its isoforms to the expression of the said control gene in said patient cancer sample, comparing said gene expression level ratio to a corresponding threshold value, diagnosing cancer aggressiveness if the said ratio is superior to its corresponding threshold value, wherein the threshold value is 15.8, wherein an expression level ratio lower than the threshold value indicates less aggressiveness of the cancer and a better diagnosis or chance of survival as compared to a patient whose cancer sample yields an expression level ratio higher than the threshold value, wherein the control gene is IPO8, and wherein the expression level of POLQ and IPO8 is determined by detecting POLQ and IPO8 mRNA.