Patent ID: 8759404

Claim:
A stable, intravenously administrable, propofol oil-in-water emulsion composition, comprising triglyceride oils in an amount of 1-30% (w/v); emulsifiers selected from purified natural phosphatides; water; tonicity modifying agents; and preservative system consisting essentially of monoglyceryl ester of lauric acid (monolaurin) in an amount of 0.001% (w/v) to 0.1% (w/v) and a member selected from the group consisting of (a) capric acid and/or its soluble alkaline salts or its monoglyceryl ester (monocaprin) in an amount of 0.001% (w/v) to 0.1% (w/v) when expressed as capric acid; (b) edetate in an amount of 0.001% (w/v) to 0.0025% (w/v) when expressed as disodium edetate; and (c) capric acid and/or its soluble alkaline salts or its monoglyceryl ester (mono caprin) in an amount of 0.001% (w/v) to 0.1% (w/v) when expressed as capric acid and edetate in an amount of 0.001% (w/v) to about 0.0025% (w/v) when expressed as disodium edetate.