Patent ID: 8273371

Claim:
A pharmaceutical composition for the immediate release of a poorly soluble drug, comprising said poorly soluble drug and a substantially ordered mesoporous silica, wherein the drug molecules are loaded on the mesoporous silica material, wherein the water solubility of said biologically active species is below 2.5 mg/ml, wherein the molecular weight of said poorly soluble drug is between about 200 and 1,000 Daltons, and wherein said ordered silica has one level of porosity or structural order, has a highly ordered, two-dimensional hexagonal (P6mm) honeycomb mesostructure, which upon calcination at 500° C. yields porous structures with high BET surface areas of 690 to 1040 m 2 /g and pore volumes up to 2.5 cm 3 /g, ultra large d(100) spacings of 7.45-45 nm, and silica wall thicknesses of 3.1 to 6.4 nm, and has a pore size in the range 6 nm to 14 nm and is obtained in the absence of an alpha-tocopherol polyethylene glycol ester templating biomolecule.