Patent ID: 8199322

Claim:
A method to determine the concentration of analytes in tissues and samples, the method comprising: a. illuminating a tissue or a sample with a plurality of light wavelengths with one or more light emitters; b. measuring intensity values of light propagated from the tissue or sample at a plurality of distances from the one or more light emitters with at least one detector configured for detecting light, wherein light is measured at a first lateral distance and at a second lateral distance, wherein the first lateral distance is smaller than the second lateral distance; c. calculating one or more scattering coefficients μ s ′ for the plurality of light wavelengths based on the light intensity values measured at the first lateral distance; and d. calculating analyte concentrations using a diffusion model, one or more of the scattering coefficients μ s ′ and the intensity values at the plurality of light wavelengths measured at the second lateral distance.