Patent ID: 7687624

Claim:
A process for the preparation of a compound of formula I in which X denotes R 1 denotes NO 2 , CN, COOR 3 , CON(R 3 ) 2 , COR 3 , SO 2 R 4 , SO 2 N(R 3 ) 2 , CF 3 , F or Cl, R 2 denotes H, Hal, A, OR 3 , N(R 3 ) 2 , NO 2 , CN, COOR 3 , CON(R 3 ) 2 , NR 3 COA, NR 3 CON(R 3 ) 2 , NR 3 COOR 3 , NR 3 SO 2 A, —[C(R 5 ) 2 ] n —Ar, —[C(R 5 ) 2 ] n -Het, —[C(R 5 ) 2 ] n -cycloalkyl, COR 3 , SO 2 N(R 3 ) 2 or SO 2 R 4 , R 3 denotes H, A, —[C(R 5 ) 2 ] n —Ar or —[C(R 5 ) 2 ] n -Het, R 4 denotes A, —[C(R 5 ) 2 ] n —Ar or —[C(R 5 ) 2 ] n -Het, R 5 denotes H or A′, Ar denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR 5 , N(R 5 ) 2 , NO 2 , CN, COOR 5 , CON(R 5 ) 2 , NR 5 COA, NR 5 SO 2 A, COR 5 , SO 2 N(R 5 ) 2 or S(O) n A, Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms which is unsubstituted or mono- or disubstituted by Hal, A, OR 5 , N(R 5 ) 2 , NO 2 , CN, COOR 5 , CON(R 5 ) 2 , NR 5 COA, NR 5 SO 2 A, COR 5 , SO 2 N(R 5 ) 2 , S(O) n A and/or carbonyl oxygen (═O), A′ denotes unbranched or branched alkyl having 1-6 C atoms, A denotes unbranched, branched or cyclic alkyl having 1-12 C atoms, in which one or two CH 2 groups may be replaced by O or S atoms and/or by —CH═CH— groups and/or in addition 1-7H atoms may be replaced by F, Hal denotes F, Cl, Br or I, n denotes 0, 1 or 2, m denotes 0, 1, 2, 3 or 4, and salts thereof, characterised in that a) a compound of the formula II which has a pK a value ≦3 X—NH 2 II in which X has the meaning indicated above, is reacted with 5-chloro-2,3-dihydro-1,4-dioxin to give a compound of the formula III in which X has the meaning indicated above, b) then a compound of the formula III is cyclised to give a compound of the formula I, and c) the latter is optionally converted into its salt by converting a base or acid of the formula I into one of its salts.