Patent ID: 8536214

Claim:
A heterocyclic derivative according to formula I wherein L 1 is (CR 6 R 7 ) m or CO; L 2 is NR 8 SO 2 or SO 2 NR 9 ; R 1 is H, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy, halogen, CN, COR 10 , SR 11 , SOR 12 , SO 2 R 13 , NHCOR 14 , NHSO 2 R 15 , NHCOR 16 or CONHR 17 , said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens; R 2 is C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy, or CN, said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being substituted with one or more moiety independently selected from halogen, OH, C 1-6 alkyloxy, CN, NR 18 R 19 , COR 20 , SR 21 , SOR 22 , SO 2 R 23 , NHCOR 24 , NHSO 2 R 25 , NHCOR 26 and CONHR 27 ; R 3 is H, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy, halogen or CN, said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens; R 4 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-2 alkylC 3-8 cycloalkyl, NR 28 R 29 , C 6-10 aryl or a 5-9 membered heteroaryl ring system comprising 1-2 heteroatoms independently selected from O, S and N, wherein said C 1-6 alkyl, C 3-8 cycloalkyl, C 6-10 aryl and 5-9 membered heteroaryl ring system are optionally substituted with one or more moieties independently selected from halogen, C 1-6 alkyl, hydroxy and C 1-6 alkyloxy, said C 1-6 alkyl, and C 1-6 alkyloxy being optionally substituted with 1-3 halogens; R 6 -R 10 are independently H or C 1-6 alkyl; R 11 -R 16 are independently C 1-6 alkyl; R 17 is H or C 1-6 alkyl; R 18 and R 19 are independently H or C 1-4 alkyl optionally substituted with a 5-9 membered heteroaryl ring system comprising 1-2 heteroatoms independently selected from O, S and N, or R 18 and R 19 together with the N to which they are bonded form a 4-6 membered saturated or unsaturated heterocyclic ring optionally comprising another heteroatom selected from O, S and N(R 30 ) p ; R 20 is independently H or C 1-4 alkyl; R 21 -R 26 are independently C 1-4 alkyl; R 27 is H or C 1-4 alkyl; R 28 and R 29 are independently H or C 1-4 alkyl or R 28 and R 29 together with the N to which they are bonded form a 4-6 membered saturated or unsaturated heterocyclic ring optionally comprising another heteroatom selected from O, S and N; R 30 is H or C 1-4 alkyl; m is 1-2; n is 1-3; p is 0 or 1; X 1 and X 3 are independently O, S, N or CR 31 and X 2 is N or CR 31 with the proviso that at least one of X 1 -X 3 must be N and that no more than one of X 1 and X 3 can be O or S or X 3 together with R 2 , wherein X 3 is CR 31 , form a 5 to 7 membered unsaturated carbocyclic ring optionally comprising a N; Y 1 -Y 3 are CR 32 ; R 31 is H or C 1-6 alkyl; and R 32 is H, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy, halogen or CN, said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens; or a pharmaceutically acceptable salt thereof.