Patent ID: 7960373

Claim:
A compound of formula (I) wherein: a) R 1 is independently selected from the group consisting of (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkyl(C1-C12)alkyl, cycloalkyl(C2-C12)alkenyl, cycloalkyl(C2-C12)alkynyl, heterocyclyl(C1-C12)alkyl, heterocyclyl(C2-C12)alkenyl, heterocyclyl(C2-C12)alkynyl, aryl(C1-C12)alkyl, aryl(C2-C12)alkenyl, aryl(C2-C12)alkynyl, heteroaryl(C1-C12)alkyl, heteroaryl(C2-C12)alkenyl and heteroaryl(C2-C12)alkynyl, the aryl group of each R 1 being optionally substituted with one or more halogens; b) R 2 is selected from the group consisting of (C1-C6)alkyl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl, heteroaryl, (C1-C6)alkylthio(C1-C6)alkyl, di(C1-C6)alkylamino(C1-C6)alkyl, aryloxy(C1-C6)alkyl and (C1-C6)alkoxy(C1-C6)alkyl; c) R 3 is selected from the group consisting of H, COO(R 5 ), CONH(R 5 ), CO(R 5 ), O(R 5 ) and R 5 ; d) R 4 is independently selected from the group consisting of H, F, Cl, Br, N(R 5 ) 2 , NO 2 , CN, COO(R 5 ), CON(R 5 ) 2 , NHCO(R 5 ), NHCOO(R 5 ), OCONH(R 5 ), O(R 5 ) and R 5 , or alternatively two substituents R 4 , linked to two adjacent carbons of the phenyl, together form a ring chosen from cycloalkyl, heterocyclyl, aryl and heteroaryl, optionally substituted with one or more R 4 ; e) m has the value 0, 1, 2, 3 or 4; f) X is chosen from S, SO and SO 2 ; g) R 5 is independently chosen from a non-bonding lone pair of electrons, H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, halo(C1-C12)alkyl, aryl(C1-C12)alkyl, heteroaryl(C1-C12)alkyl, heteroarylaryl(C1-C12)alkyl, aryl, heteroaryl and cycloalkyl, in which each R 5 is optionally substituted with at least one substituent chosen from OH, halogen, (C1-C4)alkyl, (C1-C4)alkoxy, aryl(C1-C4)alkyl, aryl, heteroaryl(C1-C4)alkyl, heteroaryl, —N(CH 3 ) 2 , —NH 2 , CONH 2 , each of the Rz is independently selected from the group consisting of H, COO(R 5 ), CONH(R 5 ), CON(R 5 ) 2 , CO(R 5 ) and R 5 , in which each R 5 is independently chosen from (C1-C4)alkyl, halo(C1-C4)alkyl, aryl(C1-C4)alkyl and heteroaryl(C1-C4)alkyl, in which each R 5 is optionally substituted with a substituent chosen from OH, halogen, (C1-C4)alkyl, (C1-C4)alkoxy, aryl(C1-C4)alkyl, aryl, heteroaryl(C1-C4)alkyl and heteroaryl; or a pharmaceutically acceptable salt of such compound, wherein heteroaryl is a monocyclic or polycyclic heteroaromatic substituent containing from 1 to 13 carbon atoms and from 1 to 4 heteroatoms selected from oxygen, sulphur, nitrogen and selenium, and heterocyclyl is a saturated or partially unsaturated cyclic hydrocarbon based substituent containing from 1 to 13 carbon atoms and from 1 to 4 heteroatoms selected from oxygen, sulphur, nitrogen and selenium provided that when R 1 is (E) —CH═CH—C(CH 3 ) 3 , R 2 is methyl, X is S and m is 0, then R 3 is other than a hydrogen atom, a (3,5-difluorophenyl)methyl group or a —CH 2 —CH═CH 2 group.