Patent ID: 7638526

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, solvate, prodrug or stereoisomer thereof, wherein: R 1 is selected from the group consisting of: (1) aryl and (2) substituted aryl, and wherein: the substituted aryl moieties are each independently substituted with one or more substituents independently selected from the group consisting of: (a) —(C═N—O-alkyl)CH 3 , (b) —NC(O)NH 2 , (c) —NC(O)NH(alkyl), (d) —NC(O)N(alkyl) 2 , (e) —SO 2 NH 2 , (f) —SO 2 NH(alkyl), (g) —SO 2 N(alkyl) 2 , (h) —CF 3 , (i) —OH, (j) -halo, (k) —CN, (l) -alkoxy, (m) —C(O)O-alkyl, (n) —S(O)alkyl, (o) —SO 2 -alkyl, (p) —P(O)(O-alkyl) 2 , and (q) alkyl; R 2 is —C(O)NHQ A wherein Q A is substituted aryl, and wherein: the substituted aryl is substituted with one or more substituents independently selected from the group consisting of: (a) —(C═N—O-alkyl)CH 3 , (b) —NC(O)NH 2 , (c) —NC(O)NH(alkyl), (d) —NC(O)N(alkyl) 2 , (e) —SO 2 NH 2 , (f) —SO 2 NH(alkyl), (g) —SO 2 N(alkyl) 2 , (h) —CF 3 , (i) —OH, (j) -halo, (k) —CN, (l) -alkoxy, (m) —C(O)O-alkyl, (n) —S(O)alkyl, (o) —SO 2 -alkyl, (p) —P(O)(O-alkyl) 2 , and (q) alkyl; R 3 is selected from the group consisting of: (1) heteroaryl and (2) substituted heteroaryl; and wherein: the substituted heteroaryl is substituted with one or more substituents independently selected from the group consisting of: (a) —(C═N—O-alkyl)CH 3 , (b) —NC(O)NH 2 , (c) —NC(O)NH(alkyl), (d) —NC(O)N(alkyl) 2 , (e) —SO 2 NH 2 , (f) —SO 2 NH(alkyl), (g) —SO 2 N(alkyl) 2 , (h) —CF 3 , (i) —OH, (j) -halo, (k) —CN, (l) -alkoxy, (m) —C(O)O-alkyl, (n) —S(O)alkyl, (o) —SO 2 -alkyl, (p) —P(O)(O-alkyl) 2 , and (q) alkyl; and Each R 4 is —CH 2 —, and v is 2; Each R 5 is —CH 2 —, and u is 2; and wherein for compound of formula IIIC: when R 1 is then R 2 is not: wherein for compound of formula IIIC: when R 1 is then R 2 is not: wherein for compound of formula IIIC: when R 1 is then R 2 is not: wherein for compound of formula IIID: when R 1 is then R 2 is not: wherein for compound of formula IIID: when R 1 is then R 2 is not: