Patent ID: 8530511

Claim:
A regime or regimen for increasing the level of intracellular glutathione in a subject in need of such treatment, comprising administering thereto a thus effective amount of at least one dithiolane compound having the formula (I): in which: Y is O, NR 1 or S; R 1 is a hydrogen atom, a saturated linear C 1 -C 20 or branched C 3 -C 20 or unsaturated C 2 -C 20 alkyl hydrocarbon-based radical, a phenyl radical optionally substituted with one or more hydroxyl groups and/or with one or more C 1 -C 8 alkoxy radicals; R is a hydrogen atom, a saturated linear C 1 -C 20 or branched C 3 -C 20 or unsaturated C 2 -C 20 alkyl hydrocarbon-based radical, a phenyl radical optionally substituted with one or more hydroxyl groups and/or with one or more C 1 -C 8 alkoxy radicals, or a saturated C 1 -C 8 alkyl radical containing a phenyl substituent optionally substituted with one or more hydroxyl groups and/or with one or more C 1 -C 8 alkoxy radicals; R optionally bears one or more substituents selected from among OR 2 , SR 2 , NR 2 R 3 and COOR 2 in which: R 2 is a hydrogen atom or a saturated linear C 1 -C 5 or branched C 3 -C 5 or unsaturated C 2 -C 5 hydrocarbon-based radical, or a phenyl radical; R 3 is a hydrogen atom, a saturated linear C 1 -C 5 or branched C 3 -C 5 or unsaturated C 2 -C 5 hydrocarbon-based radical, a phenyl radical, or an acetyl radical, with the proviso that when Y is NR 1 , R and R 1 may together form a ring member selected from among pyrrolidine, pyrroline, piperazine, morpholine, thiomorpholine and azepine; m=0 or 1 or 2; n=0 or 1 or 2; and also the salts, chelates, and optical isomers thereof.