Patent ID: 8513442

Claim:
A method comprising combining a hetero-olefin, a metal-free chiral hydrogen-bond donor, and a reactant selected from the group consisting of a diene, an alkyne and a nucleophile with a solvent to form a solution for a time sufficient to allow an enantioselective reaction; wherein said reaction is selected from the group consisting of Diels-Alder reaction, dipolar cycloadditions, carbene addition, cyclopropanation, aziridination, nucleophilic substitution, nucleophilic addition to carbonyls, nucleophilic addition to alpha, beta-unsaturated carbonyls, nucleophilic addition to imines, cyanohydrin formation, cyanoamine formation, and reductions; wherein said hetero-olefin has a functionality selected from the group consisting of an imine and a thioketone; and wherein said solution does not comprise a transition metal.