Patent ID: 8476404

Claim:
Conjugates of water soluble polymers with compounds of formula (I) wherein water soluble polymers are covalently attached via linker L1 or L2 n (L1-O—CH 2 —)—R—(—CH—O-L2) m (I) wherein R is hydrocarbon in polyhydric alcohols containing at least one primary hydroxyl group and at least one secondary hydroxyl group selected from group of alcohols comprising 1,2,6-hexanetriol, 1,2,4-butanetriol, glycerol, triglycerol, tetraglycerol, pentaglycerol, hexaglycerol, polyglycerol, 2,2,6,6-tetrakis(hydroxymethyl)cyclohexanol, 3-Bromo-1,2-propanediol, 3-Chloro-1,2-propanediol, 1,3-butanediol, 1,2-butanediol, 2-hydroxymethyl-1,3-propanediol, DL-threitol, 1,2-pentanediol, 1,4-pentanediol, 3-Methyl-1,3-butanediol, 1,2-hexanediol, 1,5-hexanediol, 1,2,6-hexanetriol, α,α′-diglycerol, 3-tert-butoxy-1,2-propanediol, 1-phenyl-1,2-ethanediol, 1-phenyl-1,2-ethanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol, 1,2,7,8-octanetetrol, 1-(4-nitrophenoxy)-2,3-propanediol, 4-hydroxy-3-methoxyphenylglycol, 3-benzyloxy-1,2-propanediol, mephenesin, 1,2-dodecanediol, 1,2-hexadecanediol, 1-O-palmityl-glycerol, batyl alcohol and the likes; L1 and L2 are linkers conjugated to hydroxyl groups in polyhydric alcohols and capable of undergoing further conjugation selected from group of linkers comprising N-hydroxysuccininimidyl esters, maleimidoalkanoic acids, succinic acid, succinic anhydride, p-nitrophenylchloroformate, formyl benzoic acid, isocyanates, diisocyanates, isothiocyanates, diisothiocyantes, aminoalkanoic acids, thioalkanoic acids, acetals, ketals, sulfones acrylates, methacrylates, alkyl chlorides, acyl chlorides, aldehydes and the likes and n and m are integers from 1 to 12.