Patent ID: 8796183

Claim:
A method of screening for template-fixed hairpin beta-mimetics having a template that conformationally stabilizes a beta-hairpin and which is capable of binding to a specific binding partner, comprising the steps of a) providing a library of template-fixed beta-hairpin mimetics; b) contacting the library of step a) with the binding partner; c) selecting from the library peptides capable of forming a non-covalent complex with the binding partner; and d) optionally isolating the peptides or determining their sequence by DNA-analysis, wherein the library of template-fixed beta-hairpin mimetics comprises compounds of the general formula R 1 -Cys-Z-Cys-R 2 (I), in which the two Cys residues form a disulfide bridge, R 1 and R 2 comprise Glu-Thr and Thr-Lys; or Lys-Thr and Thr-Glu; or Thr-Glu and Lys-Thr; or Thr-Lys and Glu-Thr; or Leu-Glu and Lys-Val; or Val-Lys and Glu-Leu; or Glu-Leu and Val-Lys; or Lys-Leu and Val-Glu; or Glu-Leu-Lys and Glu-Val-Lys; or Lys-Val-Glu and Lys-Leu-Glu; or Leu-Glu-Lys and Glu-Lys-Val; or Val-Lys-Glu and Lys-Glu-Leu; or Glu-Lys-Leu and Val-Glu-Lys; or Lys-Glu-Val and Leu-Lys-Glu; or Lys-Glu-Leu and Val-Lys-Glu; or Glu-Lys-Val and Leu-Glu-Lys, and Z is -Lys-Trp-Phe-Ser-Asn-His-Tyr-Gln-[SEQ ID NO:23]; or -Phe-Leu-Ala-His-Tyr-Ala-[SEQ ID NO:24].