Patent ID: 7674831

Claim:
A method of enhancing a sweet taste, comprising administering to a subject a sweet tastant and a compound of Formula I: or a physiologically acceptable salt thereof, wherein G 1 , G 2 , and G 3 are independently selected from N, S, and C; R 1 and R 2 are independently absent or selected from the group consisting of C 1-6 alkoxycarbonyl, hydrogen, C 1-6 alkyl, halogen, nitro, optionally substituted C 6-14 aryl, optionally substituted 5-14 membered heteroaryl, Ar-Q, optionally substituted (CH 2 ) n C(═O)—O—R 2a , and optionally substituted (CH 2 ) n C(═O)aryl, or R 1 and R 2 , together with the G 3 and the carbon atom to which R 1 is attached, form a C 6-14 aryl or 5- to 14-membered heterocycle, each of which is optionally substituted with 1-3 substitutents independently selected from the group consisting of amino, hydroxy, nitro, halogen, cyano, thiol, oxo, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkenyloxy, optionally substituted C 6-14 aryl; or if the bond to R 1 and/or R 2 is a double bond, then R 1 and R 2 are independently selected from ═NH and ═O; R 3 is selected from the group consisting of H, C 1-6 haloalkyl, C 1-6 alkyl, oxo, ═NH, optionally substituted C 6-14 aryl, optionally substituted 5-14 membered heterocycle, and L 1 -R 31 ; R 4 is absent or is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, optionally substituted C 6-14 aryl, and optionally substituted (CH 2 ) n C(═O)aryl, or when the bond to R 4 is a double bond, R 4 is ═O; R 5 is either absent or is selected from the group consisting of hydrogen, C 1-6 alkyl, and optionally substituted phenyl amide; R 7 is either absent or selected from the group consisting of H and C 1-6 alkyl; R 2a is C 1-6 alkyl; R 31 is H, C 1-6 alkyl, C 1-6 alkenyl, optionally substituted phenyl, amino, C 1-6 alkylamino, or C 1-6 dialkylamino; L 1 is a linker selected from the group consisting of ==Z 1 -(CH 2 ) n -Z 2 -, -(Het)-C(O)—NH—, ═N—(CH 2 ) n —C(=Z 3 )-Z 4 -, —NH—C(═O)—(CH 2 ) n - Z 1 is selected from the group consisting of ═N, —NH, O, and S; Z 2 is absent, O, S, C(═O), C(═S), —C(═O)—O, C(═S)—O, —C(═O)—NH— or —C(═S)—NH; Z 3 is O or S; Z 4 is O, S, or NH; Het is a 5- to 7-membered nitrogen-containing heterocycle; Q is CH 2 , O, NH, or S; Ar is optionally substituted aryl or optionally substituted heteroaryl; and n is 0 to 10.