Patent ID: 7282509

Claim:
A compound of formula: and pharmaceutically acceptable salts thereof, wherein the bonds at positions 3 and 4 are cis relative to each other; L is —(C 2 -C 6 alkyl)-C(O)— or —(C 3 -C 5 alkyl)— wherein one carbon of the —(C 3 -C 5 alkyl)- group may be replaced by —N(R 9 )—; R 1 is halogen; R 2 is amino, NH(C 1 -C 4 alkyl) or N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl); R 3 is OH or C 1 -C 4 alkoxy; R 4 is H or methyl; and R 5 is —O-heterocycloalkyl or heterocycloalkyl, wherein the heterocycloalkyl is aza-bicyclo-octyl, aza-bicyclo-nonyl, aza-bicyclo-decyl, piperidinyl, piperazinyl, or pyrrolidinyl, wherein the piperidinyl, piperazinyl, and pyrrolidinyl groups are unsubstituted or substituted at one or two positions with groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, hydroxyl, hydroxy C 1 -C 4 alkyl, amino, —NH(C 1 -C 4 alkyl), —N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), —(C 0 -C 6 alkyl)-C(O)R 11 , or NO 2 , wherein the aza-bicyclo-octyl, aza-bicyclo-nonyl, and aza-bicyclo-decyl nitrogen is optionally substituted with methyl or ethyl; R 9 at each occurrence is independently H or C 1 -C 4 alkyl; R 11 is C 1 -C 6 alkoxy, optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkoxy, amino, —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), —(C 0 -C 6 alkyl)-C(O)N(R 9 )-heterocycloalkyl, heterocycloalkyl, or heterocycloalkyl, wherein the heterocycloalkyl is pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl, wherein the heterocycloalkyl groups are optionally substituted with 1, 2, or 3 groups that are independently halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy, hydroxy C 1 C 6 alkyl, C 1 -C 6 alkoxycarbonyl, —CO 2 H, CF 3 , or OCF 3 ; and R 20 is C 1 -C 6 alkoxy or OH.