Patent ID: 8722082

Claim:
A lipid of formula XVII wherein: R 1 and R 2 are each independently for each occurrence optionally substituted C 10 -C 30 alkyl, optionally substituted C 10 -C 30 alkenyl, optionally substituted C 10 -C 30 alkynyl, optionally substituted C 10 -C 30 acyl, or -linker-ligand; R 3 is independently for each occurrence H, optionally substituted C 1 -C 10 alkyl, optionally substituted C 2 -C 10 alkenyl, optionally substituted C 2 -C 10 alkynyl, alkylheterocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonate, alkylamine, hydroxyalkyl, ω-aminoalkyl, ω-(substituted) aminoalkyl, ω-phosphoalkyl, ω-thiophosphoalkyl, optionally substituted polyethylene glycol (PEG, mw 100-40,000), optionally substituted mPEG (mw 120-40,000), heteroaryl, heterocycle, or linker-ligand; A1 and A2 are each independently O, S, CH2, CHF or CF2; E and F are each independently for each occurrence O, S, N(Q), C(O)O, C(O)N, S(O), S(O) 2 , SS, O═N, aryl, heteroaryl, cyclic or heterocycle; Z is N or C(R 3 ); and m and n are 0 to 5, where m and n taken together result in a 3, 4, 5, 6, 7 or 8 member ring.