Patent ID: 7419980

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: A is naphthyl, thiophenyl, pyridinyl, furanyl, benzofuranyl, isobenzofuranyl, xanthenyl, pyrrolyl, indolizinyl, isoindolyl, indolyl, benzothiophenyl, wherein any 1 to 3 carbon atom(s) of said A can be optionally replaced with a nitrogen atom, and wherein said A is optionally substituted with one or more R 1 ; W is H or —OR 9 ; R 1 is, independently, H, OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, methylenedioxy, benzyloxy (optionally substituted with one or more R 1 ), phenyloxy (optionally substituted with one or more R 1 ), naphthyloxy (optionally substituted with one or more R 1 ), nitro, trifluoromethoxy, nitrile, alkenyl, alkynyl, sulfoxide, sulfonyl, sulfonamido, phenyl (optionally substituted with one or more R 1 ), heteroaryl (optionally substituted with one or more R 1 ), heteroaryloxy (optionally substituted with one or more R 1 ), heteroaryl methyloxy (optionally substituted with one or more R 1 ), alkanoyl, alkoxycarbonyl, alkylaminocarbonyl, or amino; R 5 is H, (C 1 -C 6 )alkyl, or trifluoromethyl; R 6 and R 7 are, independently, (C 1 -C 6 )alkyl or (C 3 -C 6 )cycloalkyl; or R 6 and R 7 can together form a ring of 4 to 8 carbon atoms; where any carbon atom of said R 6 and R 7 may be optionally replaced with N, S, or O; where R 6 and R 7 may be optionally substituted with R 5 or OH; or where R 6 and R 7 can form a ring with 4 to 8 carbons fused onto a cycloalkyl ring of 4 to 6 carbon atoms; R 8 is H, (C 1 -C 6 )alkyl, benzyl (optionally substituted with benzyloxy or phenyloxy), naphthylmethyl (optionally substituted with one or more R 1 ), phenyl(C 2 -C 6 )alkyl (optionally substituted with one or more R 1 ), heteroarylmethyl (optionally substituted with R 1 ), cycloalkyl, cycloalkenyl, cycloalkylmethyl (where any carbon atom can be optionally replaced with N, S, or O and where said cycloalkylmethyl can be optionally substituted with OH, CF 3 , halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy), cycloalkenylmethyl (where any carbon atom can be optionally replaced with N, S, or O and where said cycloalkylmethyl can be optionally substituted with OH, CF 3 , halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy); or R 5 and R 8 , together with the nitrogen atom to which R 8 is attached, form a ring optionally substituted with R 5 ; R 9 is H, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkyl-C(═O); t is 1, 2, or 3; and x is 1.