Patent ID: 8389530

Claim:
A compound having the structure (I) as well as pharmaceutically acceptable salt thereof: wherein: R1 is phenyl and R2 is hydrogen or methyl, R3 is hydrogen, C1-C4 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —CN, —CF 3 , —OR4, —OCOR4-COR4, —NR4R5, —NR4COR5, —NR4COOR5, —(C1-C4 alkyl)OR4, —(C1-C4 alkyl)COR4, —(C1-C4 alkyl)NR4R5, —(C1-C4 alkyl)NR4COR5, —(C1-C4 alkyl)NR4COOR5, X is a bond, or (CH 2 )aW(CH 2 )b, (CH 2 )aW(CH 2 )bY(CH 2 )c or —[(CH 2 )aW(CH 2 )b]m-(Z)e-[(CH 2 )cY(CH 2 )d]n wherein: a, b, c and d are independently 0, 1, 2 or 3, e is 0, 1 or 2, and n and m are independently 0 or 1, and W is —CO—, —O—, —SO 2 —, —CH 2 —, —CHOH—, —NR6-, NR7CONR8 or NR7SO 2 NR8, and Y is —CO—, —O—, —SO 2 —, —CH 2 —, —CHOH— or —NR6-, NR7CONR8 or NR7SO 2 NR8 and Z is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, and when e is 2, then each Z moiety is selected independently from one another, R4, R5 and R6 are independently hydrogen, C1-C4 alkyl and where R4 and R5 together can form a 5-7 membered ring, R7 and R8 are independently hydrogen, C1-C4 alkyl and where R7 and R8 together can form a 5-7 membered ring, wherein cycloalkyl is a saturated monocyclic carbocycle containing from 3 to 7 carbon atoms; heterocycloalkyl is a saturated mono- or bicyclic heterocycle having from 3 to 14 ring members, which contains one or more heteroatom ring members selected from nitrogen, oxygen and sulphur and which is optionally substituted with R9 and/or R10 moities; aryl is a mono- or bicyclic aromatic carbocycles, optionally substituted with R9 and/or R10 moities; heteroaryl is an aromatic mono- or bicyclic heterocycle having from 5 to 10 ring members, which contains one or more heteroatom ring members selected from nitrogen, oxygen and sulphur and which is optionally substituted with R9 and/or R10 moities; and R9/R10 are independently selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —CN, -halogen, —CF3, ═O, —OR4, —NR4COR5, —NR4COOR5, —(C1-C4 alkyl)OR4, —(C1-C4 alkyl)NR4R5, —(C1-C4 alkyl)NR4COR5, —(C1-C4 alkyl)NR4COOR5, —COOH, COOR4 with R4 and R5 as defined above.