Patent ID: 7947647

Claim:
A method of producing a therapeutic effect by delivering a synthetic cell receptor into a cell infected with Listeria moncytogenes, said method comprising: contacting said cell with a synthetic cell receptor that inserts into a cell plasma membrane on a cell surface wherein said receptor comprises: a target-binding motif, wherein said target-binding motif binds or is covalently linked to a target; a linker region linking a membrane-binding element with the target-binding motif, wherein said membrane-binding element anchors said receptor into a cell plasma membrane and is a derivative of 3β-cholesterylamine or 3β-dihydrocholesterylamine; triggering receptor-mediated endocytosis of said receptor; delivery of said receptor to said cell by an endosome; disrupting said endosome by an endosome disrupter to release said target and produce said therapeutic effect and wherein said receptor is recycled to said cell surface.