Patent ID: 8524751

Claim:
A compound of formula (I): wherein R 1 is 9- or 10-membered bicyclic heteroaryl wherein the 9- or 10-membered bicyclic heteroaryl contains from one to three heteroatoms independently selected from oxygen and nitrogen and is optionally substituted by C 1-6 alkyl, C 3-6 cycloalkyl, halo, —CN or —NHSO 2 R 5 , or pyridinyl optionally substituted by one or two substituents independently selected from C 1-6 alkyl, —OR 6 , halo and —NHSO 2 R 7 ; X is —CH 2 NR 2 R 3 , C 1-6 alkyl, —CH 2 phenyl, —(CH 2 ) n OR 10 , —CH 2 SO 2 R 11 or —(CH 2 ) p C 3-6 cycloalkyl; R 2 and R 3 , together with the nitrogen atom to which they are attached, are linked to form a 6- or 7-membered heterocyclyl or a 9- or 10-membered bicyclic heterocyclyl wherein the 6- or 7-membered heterocyclyl or the 9- or 10-membered bicyclic heterocyclyl optionally contains an oxygen atom, a sulphur atom or a further nitrogen atom and is optionally substituted by from one to three substituents independently selected from oxo, C 1-6 alkyl, —(CH 2 ) m NR 8 R 9 , phenyl optionally substituted by halo, and 6-membered heteroaryl wherein the 6-membered heteroaryl contains one or two nitrogen atoms, a 7-membered bridged heterocyclyl wherein the 7-membered bridged heterocyclyl optionally contains a further nitrogen atom and is optionally substituted by from one to three substituents independently selected from C 1-6 alkyl, or a 10-membered spiro bicyclic heterocyclyl wherein the 10-membered spiro bicyclic heterocyclyl optionally contains an oxygen atom, or R 2 is hydrogen and R 3 is C 1-6 alkyl optionally substituted by one or two substituents independently selected from —OR 12 and —NR 13 R 14 ; R 4 is hydrogen or methyl; R 6 , R 12 and R 15 are each independently hydrogen or C 1-4 alkyl; R 5 and R 7 are each independently C 1-6 alkyl or phenyl wherein the phenyl is optionally substituted by one or two substituents independently selected from halo and —OR 15 ; R 8 and R 9 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom; R 19 is hydrogen, C 1-6 alkyl, —(CH 2 ) q phenyl or C 3-6 cycloalkyl wherein the C 3-6 cycloalkyl is optionally substituted by one or two substituents independently selected from C 1-6 alkyl; R 11 is C 1-6 alkyl or phenyl; R 13 and R 14 , together with the nitrogen atom to which they are attached, are linked to form a 6-membered heterocyclyl optionally containing an oxygen atom; m, p and q are each independently 0, 1 or 2; and n is 1 or 2; or a pharmaceutically acceptable salt thereof.