Patent ID: 7588911

Claim:
An assay for detecting an inhibitor of binding between cyclooxygenase-2 (COX-2) and a PDZ protein, comprising: contacting a PDZ-containing polypeptide with a COX-2 PDZ ligand-containing polypeptide in the presence and absence of a test agent, and determining binding between the PDZ-containing polypeptide with a COX-2 PDZ ligand-containing polypeptide in the presence and absence of the test agent; wherein reduced binding in the presence of the test agent indicates that the test agent inhibits binding of a PDZ-containing polypeptide to a COX-2 PDZ ligand-containing polypeptide, and wherein the COX-2 PDZ ligand-containing polypeptide comprises at least five contiguous C-terminal amino acids from SEQ ID NO: 13.