Patent ID: 7462620

Claim:
A compound of formula (I): in which: R 1 is phenyl unsubstituted or substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from the group consisting of C( 1-6 )alkyl, C( 1-6 )alkoxy, C( 1-6 )alkylthio, hydroxy, halogen, CN, and mono to perfluoro-C( 1-4 )alkyl; R 2 and R 3 together with the pyrimidone ring carbon atoms to which they are attached form a fused 5- membered carbocyclic ring; R 1 is C( 1-6 )alkyl which may be unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of hydroxy, OR 7 , COR 7 , carboxy, COOR 7 , CONR 9 R 10 , NR 9 R 10 , NR 7 COR 8 , mono- or di-(hydroxyC( 1-6 )alkyl)amino and N-hydroxyC( 1-6 )alkyl-N-C( 1-6 )alkylamino, or R 4 is Het-C( 0-4 )alkyl in which Het is a 5- to 7- membered heterocyclyl ring comprising N and optionally O or S, and in which N may be substituted by COR 7 , COOR 7 , CONR 9 R 10 , or C( 1-6 )alkyl unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of hydroxy, halogen, OR 7 , COR 7 , carboxy, COOR 7 , CONR 9 R 10 and NR 9 R 10 ; R 5 is an aryl or a heteroaryl ring optionally substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from the group consisting of C( 1-6 )alkyl, C( 1-6 )alkoxy, C( 1-6 )alkylthio, arylC( 1-6 )alkoxy, hydroxy, CN, COR 7 , carboxy, COOR 7 , NR 7 COR 8 , CONR 9 R 10 , SO 2 NR 9 R 10 , NR 7 SO 2 R 8 , NR 9 R 10 , mono to perfluoro-C( 1-4 )alkyl and mono perfluoro-C( 1-4 )alkoxy; R 6 is an aryl or a heteroaryl ring which is unsubstituted or substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from the group consisting of C( 1-18 )alkyl, C( 1-18 )alkoxy, C( 1-6 )alkylthio, C( 1-6 )alkylsulfonyl, arylC( 1-6 )alkoxy, hydroxy, halogen, CN, COR 7 , carboxy, COOR 7 , CONR 9 R 10 , NR 7 COR 8 , SO 2 NR 9 R 10 , NR 7 SO 2 R 8 , NR 9 R 10 , mono to perfluoro-C( 1-4 )alkyl and mono to perfluoro-C( 1-4 )alkoxy, and C( 5-10 )alkyl; R 7 is hydrogen or C( 1-4 )alkyl; R 8 is hydrogen, or C( 1-4 )alkyl; R 9 and R 10 are independently hydrogen, C( 1-12 )alkyl, or R 9 and R 10 together with the nitrogen to which they are attached form a 5- to 7 membered ring optionally containing one or more additional heteroatorns selected from the group consisting of oxygen, nitrogen and sulphur, and optionally substituted by one or two substituents selected from the group consisting of hydroxy, oxo, C( 1-4 )alkyl, C( 1-4 )alkylcarboxy, and aryl; X is —CH 2 —CH 2 —; or a pharmaceutically acceptable salt thereof; excluding N-(2-diethylaminoethyl)-2-[2-(2-(2,3-difluorophenyl)ethyl)-4-oxo-4,5,6,7-tetrahydro-cyclopentapyrimidin-1-yl]-N-(4′-trifluoromethyl-biphenyl-4-ylmethyl)acetamide or a pharmaceutically acceptable salt thereof.