Patent ID: 7531550

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof wherein: R 1 and R 2 are each independently hydrogen, halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 6 alkoxy, or C 1 -C 6 alkylester; or R 1 and R 2 are joined by a —O—CH 2 —O— group; R 3 is hydrogen or methoxy; R 4 and R 5 are independently methyl or hydrogen; or R 4 and R 5 are joined to form a 5-membered heterocyclic ring containing no additional heteroatoms; and R is (i) a group of the formula -AB, where A is —NR 6 —, —O—, —NR 6 (C═O)—, —S(O) m —, —CH 2 C(═O)—, —S(O) m NR 6 —, —NR 6 S(O) m —, —OS(O) m —NR 6 (S═O)NR 7 —, —O(C═O)—, or —NR 6 (C═O)NR 7 —, where m is 0, 1, or 2; B is C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 2 -C 4 alkanoyl, (carbocycle)C 0 -C 2 alkyl or (heterocycle)C 0 -C 2 alkyl, wherein the heterocycle has from 1 to 3 fused or pendant rings, each of which B is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxyl, amino, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 6 alkylester, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; (ii) (iii) a 5-membered heteroaryl group having at least one nitrogen ring member, and 0, 1, or 2 additional ring members independently chosen from N, O, and S, wherein the 5-membered heteroaryl group is attached via a nitrogen atom and is substituted with 0 to 3 substituents independently chosen from halogen, hydroxyl, amino, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; or (iv) a 5- or 6-membered heterocycloalkyl group linked via a nitrogen atom, wherein the heterocycloalkyl is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxyl, amino, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 6 alkylester, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and 5- and 6-membered heterocycloalkyl; where R 6 , R 7 , R 8 , R 9 , and R 10 are each independently hydrogen, or C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 2 -C 4 alkanoyl, (C 3 -C 10 cycloalkyl)C 0 -C 8 alkyl, (heterocycloalkyl)C 0 -C 8 alkyl, or phenyl each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxyl, amino, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.