Patent ID: 7465794

Claim:
An isolated polynucleotide molecule comprising a recombinant respiratory syncytial virus (RSV) genome or antigenome comprising polynucleotide sequences encoding a major nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large polymerase protein (L), and a M2(ORF1) polymerase elongation factor, and wherein said recombinant RSV genome or antigenome is modified to incorporate a heterologous polynucleotide sequence encoding an immune modulatory molecule selected from the group consisting of interleukin 2 (IL-2), interleukin 4 (IL-4), interferon gamma (IFNλ) and granulocyte-macrophage colony stimulating factor (GM-CSF), BlyS ligand, Flt3 and CD40.