Patent ID: 8066658

Claim:
A cartridge for use in a dialysis system for removing toxins comprising: a body having an inlet end and an outlet end; an interior including at least four layers, the layers including a first layer of a resin selected from the group consisting of zirconium phosphate having a pH of approximately 2.5 to about 5 and urease, a second layer of a resin selected from the group consisting of zirconium oxide having a pH of approximately 9 to about 13 and urease, a third layer of zirconium phosphate, and a fourth layer of zirconium oxide having a pH of approximately 6.5 to about 7.5; wherein the first layer is different from the second layer; and the interior being so constructed and arranged that a fluid entering the interior from the inlet end flows through the first layer, then the second layer, then the third layer, and then the fourth layer.