Patent ID: 7488748

Claim:
A compound having the structure of Formula I: and its pharmaceutically acceptable salts, pharmaceutically acceptable, enantiomers, diastereomers, or N-oxides, wherein Ar represents an aryl or a heteroaryl ring having 1-2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), trifluoromethyl cyano, hydroxy, nitro, halogen (e.g. F, Cl, Br or I), lower alkoxy (C 1 -C 4 ), amino or lower alkylamino(C 1 -C 4 ); R 1 represents a hydrogen, hydroxy, hydroxymethyl, loweralkyl (C 1 -C 4 ), amino, alkoxy, cycloalkyl (C 3 -C 7 ), carbamoyl, halogen (e.g. F, Cl, Br, I) or aryl; R 2 represents alkyl, C 3 -C 7 cycloalkyl ring, C 3 -C 7 cycloalkenyl ring, an aryl or a heteroaryl ring having 1 to 2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms; the aryl or a hetero aryl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), trifluoromethyl, cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), unsubstituted amino or lower alkyl (C 1 -C 4 ) amino; W represents (CH 2 ) p , where p represents 0 to 1; X represents an oxygen, sulphur, NR or no atom wherein R represents hydrogen or C 1-6 alkyl; Y represents CHR 5 CO wherein R 5 represents hydrogen or methyl, or (CH 2 )q wherein q represents 0 to 4; m represents 0 to 2; R 3 represents hydrogen, lower alkyl (C 1 -C 4 ) or CO 2 C (CH 3 ) 3 ; and R 4 represents C 1 -C 15 saturated or unsaturated aliphatic hydrocarbon (straight chain or branched) in which any 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen (e.g. F, Cl, Br, I), carboxylic acid, carboxylic acid ester, aryl, aryloxy, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl having 1 to 2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulphur with option that any 1 to 5 hydrogen atoms on the ring in said aryl, aryloxy, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkenyl may be substituted with lower alkyl, trifluoromethyl, halogen (e.g. F, Cl, Br, I), cyano, nitro, hydroxy, lower (C 1 -C 4 ) alkoxy, amino, lower (C 1 -C 4 ) alkylamino, sulphonylamino, amide, carboxylic acid, carboxylic acid ester or benzyl ester.