Patent ID: 6906095

Claim:
A compound of formula I wherein X is N or CR 3 ; Y is N or CR 4 ; Q is SO 2 , CO, CO 2 , CONR or CSNR 12 ; R 1 , R 2 , R 3 and R 4 are each independently H, halogen, CN, OCO 2 R 13 , CO 2 R 14 , CONR 15 R 16 , NR 17 SO 2 R 18 , NR 19 COR 28 , SO n R 20 , NR 21 R 22 , OR 23 , COR 24 or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 5 , R 6 and R 7 are each independently H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 12 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted or R 5 and R 6 maybe taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered ring; R 8 is H or a C 1 -C 6 alkyl or C 3 -C 10 cycloalkyl group each optionally substituted; R 9 is H, halogen, CN, NO 2 , NR 25 R 26 , OR 27 or a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted or R 8 and R 9 may be taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing one or two heteroatoms selected from O, N or S; R 10 is a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S with the proviso that when R 8 is H or C 1 -C 6 alkyl and Q is CO then R 10 must be other than C 1 -C 6 alkyl or aryl; n is 0 or an integer of 1 or 2; R 11 and R 12 are each independently H or a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted; R 13 , R 14 , R 18 , R 20 , R 23 , R 24 , R 27 and R 28 are each independently H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 15 and R 16 are each independently H or an optionally substituted C 1 -C 6 alkyl group; and R 17 , R 19 , R 21 , R 22 , R 25 and R 26 are each independently H or an optionally substituted C 1 -C 4 alkyl group or R 21 and R 22 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, N or S; or the stereoisomers thereof, the tautomers thereof or the pharmaceutically acceptable salts thereof.