Patent ID: 8633237

Claim:
An indane compound according to formula I wherein L 1 is O, (CR 5 R 6 ) m , OCR 7 R 8 or CR 9 R 10 O; L 2 is NR 11 SO 2 or SO 2 NR 12 ; X 1 -X 4 are CR 1 ; R 1 is H, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy, halogen, CN, SC 1-6 alkyl, SOC 1-6 alkyl, SO 2 C 1-6 alkyl, NR 13 SO 2 R 14 , CH 2 NR 15 SO 2 R 16 , CONR 17 R 18 , NR 19 COR 20 or SO 2 NR 21 R 22 , said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens with the proviso that each R 1 cannot simultaneously be H; or two R 1 together form a fused 5- or 6-membered heteroaryl ring comprising 1-3 heteroatoms independently selected from O, S and N; R 2 is C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkyloxy or CN, said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being substituted with one or more moiety independently selected from OH, C 1-6 alkyloxy and NR 23 R 24 ; R 3 is H, C 1-6 alkyl C 3-8 cycloalkyl, C 1-6 alkyloxy, halogen or CN, said C 1-6 alkyl, C 3-8 cycloalkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens; R 4 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-2 alkyl, NR 25 R 26 , C 6-10 aryl or a 5-9 membered heteroaryl ring system comprising 1-3 heteroatoms independently selected from O, S and N, wherein said C 1-6 alkyl, C 3-8 cycloalkyl, C 6-10 aryl and 5-9 membered heteroaryl ring system are optionally substituted with one or more moieties independently selected from halogen, C 1-6 alkyl, hydroxy and C 1-6 alkyloxy, said C 1-6 alkyl, and C 1-6 alkyloxy being optionally substituted with 1-3 halogens; R 5 -R 13 are independently H or C 1-6 alkyl; R 14 and R 16 are independently C 1-6 alkyl; R 15 , R 17 , R 18 and R 19 are independently H or C 1-6 alkyl; R 20 is C 1-6 alkyl; R 21 and R 22 are independently H or C 1-6 alkyl R 23 and R 24 are independently H or C 1-4 alkyl or R 23 and R 24 together with the N to which they are bonded form a 4-6 membered saturated or unsaturated heterocyclic ring optionally comprising another heteroatomic moiety selected from O, S and N(R 27 ) p ; R 25 and R 26 are independently H or C 1-4 alkyl or R 25 and R 26 together with the N to which they are bonded form a 4-6 membered saturated or unsaturated heterocyclic ring optionally comprising another heteroatomic moiety selected from O, S and N(R 28 ) q ; R 27 and R 28 are independently H or C 1-4 alkyl; m is 1-2; n is 0 or 1; p is 0 or 1; q is 0 or 1; Y 1 -Y 3 are CR 29 ; R 29 is H or C 1-6 alkyl optionally substituted with one or more halogens; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when L 1 is (CR 5 R 6 ) m and L 2 is a substituent at the 2-position, n cannot be 0.