Patent ID: 8207136

Claim:
A method for inhibiting tumor cell growth comprising the step of contacting a tumor cell with a nucleoside derivative in an amount sufficient to inhibit growth of the tumor cell, wherein the nucleoside derivative has the formula: or a pharmaceutically acceptable salt thereof; wherein R a , R b , R c and R h are each independently hydrogen, cyano, azido, halogen, hydroxy, mercapto, amino, C 1-4 alkoxy, C 2-4 alkenyl, C 2-4 alkynyl, or C 1-4 alkyl, wherein alkyl is unsubstituted or substituted with hydroxy, amino, C 1-4 alkoxy, C 1-4 alkylthio, or one to three fluorine atoms, or R b and R c together with the carbon atom to which they are attached form a 3- to 6-membered saturated monocyclic ring system optionally containing a heteroatom that is O, S or NC 0-4 alkyl; R d is nitro, C 1-3 alkyl, NHCONH 2 , CONR j R j , CSNR j R j , COOR j , C(═NH)NH 2 , hydroxy, C 1-3 alkoxy, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, halogen, (1,3-oxazol-2-yl), (1,3-thiazol-2-yl) or (imidazol-2-yl), wherein alkyl is unsubstituted or substituted with one to three groups that are independently halogen, amino, hydroxy, carboxy or C 1-3 alkoxy; R e and R f are each independently hydrogen, hydroxy, halogen, C 1-4 alkoxy, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 3-6 cycloalkylamino, di(C 3-6 cycloalkyl)amino, or C 4-6 cycloheteroalkyl, unsubstituted or substituted with one to two groups that are independently halogen, hydroxy, amino, C 1-4 alkyl or C 1-4 alkoxy; R i is hydrogen, C 1-10 alkylcarbonyl, P 3 O 9 H 4 , P 2 O 6 H 3 , or P(O)R m R n ; each R j is independently hydrogen or C 1-6 alkyl; R k and R g are each independently hydrogen, methyl, hydroxymethyl or fluoromethyl; and R m and R n are each independently hydroxy, OCH 2 CH 2 SC(═O)C 1-4 alkyl, OCH 2 O(C═O)OC 1-4 alkyl, NHCHMeCO 2 Me, or OCH(C 1-4 alkyl)O(C═P)C 1-4 alkyl, wherein alkyl is unsubstituted or substituted with one to three groups that are independently halogen, amino, hydroxy, carboxy, or C 1-3 alkoxy.