Patent ID: 7381746

Claim:
A 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative, a pharmaceutically acceptable salt thereof or a hydrate thereof, represented by formula [I] [wherein R 1 and R 2 are the same or different, and each represents a hydrogen atom, a C 1-10 alkyl group, a phenyl group, a naphthyl group, a C 1-10 alkyl group substituted by one or two phenyl groups, a C 2-10 alkenyl group, a C 2-10 alkynyl group, a hydroxylC 2-10 alkyl group, a C 1-10 alkoxycarbonylC 1-10 alkyl group, an aminoC 2-10 alkyl group or a C 1-10 alkoxyC 1-10 alkyl group; X represents a fluorine atom; Y represents an amino group, —SR 3 , —S(O) n R 7 , —SCHR 3 R 4 , —S(O) n CHR 3 R 4 , —NHCHR 3 R 4 , —N(CHR 3 R 4 )(CHR 5 R 6 ), —NHCOR 3 or —OCOR 7 (wherein R 3 , R 4 , R 5 and R 6 are the same or different, and each represents a hydrogen atom, a C 1-10 alkyl group, a phenyl group, a naphthyl group, a naphthyl group substituted by one to seven halogen atoms or a hetroaromatic group, or represents “a phenyl group substituted by one to five substituents selected from a group consisting of a halogen atom, a phenyl group, a C 1-10 alkyl group, a C 1-10 alkoxy group and a trifluoromethyl group”; R 7 represents a C 1-10 alkyl group, a phenyl group, a naphthyl group, a naphthyl group substituted by one to seven halogen atoms or a hetroaromatic group, or represents “a phenyl group substituted by one to five substituents selected from a group consisting of a halogen atom, a phenyl group, a C 1-10 alkyl group, a C 1-10 alkoxy group and a trifluoromethyl group”; and n represents integer 1 or 2)].