Patent ID: 7732195

Claim:
A vector for expressing immunoglobulins comprising: an origin of replication; a first polynucleotide encoding an immunoglobulin heavy chain constant domain or an immunoglobulin light chain constant domain; a second polynucleotide encoding an immunoglobulin heavy chain constant domain or an immunoglobulin light chain constant domain; and a polynucleotide encoding a cell surface tether domain selected from the group consisting of platelet derived growth factor receptor (PDGF-R) transmembrane domain (SEQ ID NO:4), B7-1 (CD80) transmembrane domain (SEQ ID NO:6), and glycosidylphosphatidylinositol (GPI) signal domain (SEQ ID NO:2), wherein said polynucleotide encoding a cell surface tether domain is flanked by a first and a second restriction endonuclease recognition site.