Patent ID: 8541186

Claim:
A method for detecting and/or measuring an occurrence of an enzyme CYP1B1 in a patient, said method comprising the steps of: a) administering a reporter substrate to a patient; b) taking a bodily fluid and/or tissue sample from the patient after one or more pre-determined periods of time; and c) analyzing the bodily fluid and/or tissue sample in vitro for the occurrence and/or measurement of a metabolite of the reporter substrate known to be metabolized by CYP1B1 in the human or animal patient, wherein the reporter substrate includes any or any combination of a luteolin, 13 C-luteolin, 2 H-luteolin, eupatorin or 13 C-eupatorin, and the reporter metabolite is 6-hydroxy-luteolin, desmethyleupatorin, formaldehyde and/or carbon dioxide.