Patent ID: 7022667

Claim:
A compound of Formula I, including pharmaceutically acceptable salts thereof, wherein: W is Z is selected from the group consisting of —NH 2 and R 1 is selected from the group consisting of hydrogen, —P(O)A 1 A 2 , —C(O)C 1-6 alkyl, —C(O)aryl, —C(O)NHC 1-6 alkyl, —C(O)NHaryl, —(CH 2 CH 2 O) m Me, —C 1-6 alkenyl, —C 1-6 alkynyl, and —C 1-6 alkyl; wherein said C 1-6 alkyl is optionally substituted by one to six hydroxy or optionally substituted by one to two same or different substituents selected from the group consisting of (a)–(i): (a) CO 2 R 3 ; (b) CONR 4 R 5 ; (c) OP(O)A 1 A 2 ; (d) SO 3 H; (e) —O(CH 2 ) n SiR 6 3 ; (f) heteroalicyclic selected from the group consisting of pyrrolidinyl, piperidinyl, piperazinyl, and morpholinyl; (g) cyano; (h) epoxy; and (i) aryl; and provided that R 1 and R 2 are not simultaneously H; R 2 is selected from the group consisting of hydrogen, —P(O)A 1 A 2 , —SO 3 H, —C(O)C 1-6 alkyl, —C(O)CH═CHCO 2 R 3 , —C(O)aryl, —C(O)N(H)(C 1-6 alkyl-T), —C(O)N(Me)(C 1-6 alkyl-T), —(CH 2 CH 2 O) p H, —(CH 2 CH 2 O) q Me, —C 1-6 alkenyl, —C 1-6 alkyl and —C 1-6 alkynyl; wherein said —C 1-6 alkyl is optionally substituted by one to six hydroxy or optionally substituted by one to two same or different substituents selected from the group consisting of (j)–(v): (j) halo; (k) CO 2 R 3 ; (l) CONR 4 R 5 ; (m) OP(O)A 1 A 2 ; (n) P(O)A 1 A 2 ; (O)SO 3 H; (p) —O(CH 2 ) r SiR 6 3 ; (q) heterocyclic or heteroalicyclic selected from the group consisting of pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, imidazolyl, and pyridyl; (r) cyano; (s) azido; (t) aryl; (u) NR 4 R 5 ; and (v) R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl, allyl, benzyl, 2-hydroxyethyl, and 2-tetrahydropyranyl; R 4 and R 5 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, CH 2 CN, CH 2 CH 2 NH(t-butyloxycarbonyl), C(═NH)NH 2 and SO 2 N(C 1-6 alkyl) 2 ; or R 4 and R 5 taken together with the nitrogen to which they are attached form a heterocyclic or heteroalicyclic selected from the group consisting of pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, imidazolyl, and pyridyl; R 6 is selected from C 1-6 alkyl and phenyl; A 1 and A 2 are each independently selected from the group consisting of hydrogen, —C 1-6 alkyl, —OC 1-6 alkyl, benzyloxy, 2-chloroethoxy, and hydroxy; T is selected from the group consisting of hydrogen, —OH, —(CH 2 CH 2 O) s H, —(CH 2 CH 2 O) t CH 3 and —NR 4 R 5 ; m, n, p, q, r, s and t are independently 1–6; and aryl consists of a phenyl group optionally substituted with halo or —CO 2 R 3 .