Patent ID: 8444993

Claim:
A method of enhancing a body's response to an immunogen, comprising: immunizing a subject in need thereof with a vaccine composition in a W/O/W emulsion wherein the emulsion does not contain poloxamers comprising: (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion, comprising: (i) a continuous aqueous phase comprising H 2 O; (ii) an oil phase dispersed in the continuous aqueous phase, comprising: (1) oil; (1) an internal aqueous phase comprising H 2 O, being dispersed in the oil; and (2) a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-ε-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.