Patent ID: 8642620

Claim:
A compound of formula I, wherein: A is: which is optionally substituted by one or more identical or different substituents R 4 ; Het is pyridinediyl, optionally substituted by one or more identical or different substituents R 5 ; X is a direct bond; R 1 and R 2 , together with the N—CO group to which they are attached, form a 5-membered or 6-membered monocyclic saturated ring, which, in addition to the ring nitrogen atom being part of the N—CO group, optionally contains one additional hetero ring member NR 12 , wherein the 5-membered or 6-membered ring is optionally substituted by one or more identical or different substituents R 8 ; R 3 is selected from phenyl, naphthalenyl, and thienyl, each of which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkyloxy-(C 1 -C 2 )-alkyl-, OH, (C 1 -C 4 )-alkyloxy, (C 1 -C 2 )-alkylenedioxy, (C 1 -C 4 )-alkylmercapto, NH 2 , (C 1 -C 4 )-alkylamino, di((C 1 -C 4 )-alkyl)amino, ((C 1 -C 4 )-alkyl)-CONH—, di((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyloxy)carbonyl-, COOH, CONH 2 , CN, CF 3 , H 2 NSO 2 — and (C 1 -C 4 )-alkyl-SO 2 —, wherein the substituents (C 1 -C 4 )-alkyloxy and (C 1 -C 2 )-alkylenedioxy are each independently optionally substituted by one or more fluorine atoms; R 4 is (C 1 -C 4 )-alkyl or fluorine; R 5 is halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkyloxy-(C 1 -C 2 )-alkyl-, OH, (C 1 -C 4 )-alkyloxy, (C 1 -C 4 )-alkylmercapto, NH 2 , (C 1 -C 4 )-alkylamino, di((C 1 -C 4 )-alkyl)amino, ((C 1 -C 4 )-alkyl)-CONH—, di((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyloxy)carbonyl-, COOH, CONH 2 , CN, CF 3 or (C 1 -C 4 )-alkyl-SO 2 —, wherein the substituent (C 1 -C 4 )-alkyloxy is optionally substituted by one or more fluorine atoms; R 8 is selected from halogen, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl-C n H 2n —, phenyl-C n H 2n — and oxo, wherein said phenyl is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, CF 3 and (C 1 -C 4 )-alkyloxy; R 12 is selected from hydrogen, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl-C n H 2n —, and phenyl-C n H 2n —, wherein phenyl is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, CF 3 and (C 1 -C 4 )-alkyloxy; n is 0, 1 or 2; or its stereoisomeric form or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof.