Patent ID: 8206942

Claim:
A method for identifying a compound expected to be useful in inhibiting LRRK2 protein kinase activity, the method comprising the steps of: (1) determining whether the compound inhibits the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide wherein the LRRK2 polypeptide comprises a sequence having at least 85% identity to a wild type human LRRK2 (SEQ ID NO:69) or fragment thereof, and wherein the substrate polypeptide comprises the sequence (W/R)(X)(X)(F/Y/H/T)(Y/W/R)(T)(X)(R/T)(R)(X) (SEQ ID NO:71), where X represents any amino acid: and (2) selecting the compound that inhibits the protein kinase activity of the LRRK2 polypeptide.