Patent ID: 8540866

Claim:
A method for detecting bimolecular interactions, the method comprising: providing a sample analyzer comprising an array of at least 10 5 sensors formed in a substrate, the sensors comprising a field-effect transistor including a gate oxide, a floating gate comprising conductors formed in a plurality of conductor layers and electrically coupled to one another, and a passivation layer overlying the floating gate, the sample analyzer further comprising signal lines for the sensors within at least one of the conductor layers; disposing at least one antibody in proximity to or in contact with at least a portion of the sensors of the array; disposing at least one antigen in proximity to or in contact with at least a portion of the sensors of the array wherein interactions between the at least one antibody and the at least one antigen effectuate changes in at least one electrical property of at least a portion of the sensors of the array; and identifying interactions between the at least one antibody and the at least one antigen by detecting the changes in electrical properties of at least a portion of the sensors of the array.