Patent ID: 7585871

Claim:
A compound of Formula 1: or a pharmaceutically acceptable salt or ester form thereof, wherein: R 1 , R 2 , R 3 , and R 4 , are, independently, hydrogen, lower alkyl, halogen, or aryl; R 7 , R 8 , R 9 , and R 10 , are, independently, hydrogen, lower alkyl or halogen; R 11 , R 12 , R 14 , and R 15 are, independently, hydrogen, hydroxy, lower alkyl, alkoxy, or halogen; R 5 and R 6 are, independently, hydrogen or lower alkyl; wherein when R 5 is hydrogen, R 6 is lower alkyl, and when R 6 is hydrogen R 5 is lower alkyl; R 13 is hydrogen, —(C═O)R 16 , —S(O) 2 R 17 , —S(O) 2 N(R 18 )(R 19 ), or D-glucuronidate; R 16 is alkyl or aralkyl; R 17 is alkyl, cycloalkyl, alkenyl, cycloalkenyl, or alkynyl; and R 18 and R 19 are, independently, hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, monofluoroalkyl, perfluoroalkyl, cycloalkenyl, hydroxy-(C 2 -C 6 )alkyl, alkoxyalkyl, alkylthioalkyl, carbonyl, acyl, alkoxycarbonyl, —C(O)NH 2 , alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminoalkyl, or dialkylaminoalkyl.