Patent ID: 8372591

Claim:
A method for diagnosing high-grade cervical disease in a patient, the method comprising: a) contacting a cervical sample obtained from said patient with at least one monoclonal antibody that specifically binds to MCM7 and is selected from the group consisting of: i) the monoclonal antibody produced by the hybridoma cell line 2E6.2, deposited with the ATCC as Patent Deposit No. PTA-6669; ii) a monoclonal antibody that binds to an epitope capable of binding the monoclonal antibody produced by the hybridoma cell line 2E6.2; iii) a monoclonal antibody that binds to an epitope consisting of the amino acid sequence set forth in SEQ ID NO: 6; iv) a monoclonal antibody that competes in a competitive binding assay with the monoclonal antibody produced by the hybridoma cell line 2E6.2; and, v) a monoclonal antibody that is an antigen binding fragment of a monoclonal antibody of (i)-(iv), wherein the fragment retains the capability of specifically binding to MCM7; and, b) detecting binding of the antibody to MCM7 to determine if MCM7 is overexpressed in said cervical sample compared to a normal cervical sample, wherein overexpression is indicative of high-grade cervical disease.