Patent ID: 8034352

Claim:
A method of treating cancer and an infectious disease comprising: a) obtaining a cytokine-antibody DNL complex comprising; (i) a cytokine moiety attached to a DDD (dimerization and docking domain) moiety, wherein said DDD moiety is from a dimerization and docking domain of protein kinase A and consists of the amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2; and (ii) an antibody moiety that binds to tumor antigen wherein the antibody moiety attached to an AD (anchor domain) moiety, wherein the AD moiety is from an anchoring domain of an AKAP (A-kinase anchoring protein) and consists of the amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15 and SEQ ID NO:16, wherein the DDD moieties form a dimer that binds to the AD moiety to form the complex; and b) administering the complex to a human subject with the cancer; wherein the complex comprises an IgG antibody and the C-terminal end of each heavy chain of the IgG antibody is attached to an AD moiety, wherein each AD moiety binds to two DDD moieties and the complex comprises four copies of a cytokine.