Patent ID: 8017599

Claim:
A compound of formula (1) [M 1 -T 1 ] a -[P 1 -T 2 -M 2 ] b -[T 3 -P 2 ] c (1) or a salt thereof, wherein M 1 and M 2 are the same or different and are each a metal coordination complex selected from the group consisting of a platinum complex, a palladium complex, a ruthenium complex, and a rhodium complex, wherein at least one of M 1 and M 2 is capable of interacting with a major groove or minor groove of a polynucleotide; P 1 and P 2 are the same or different and are each a pyrrole-imidazole polyamide, wherein each pyrrole-imidazole polyamides (P 1 , P 2 ) independently comprises a plurality of heterocyclic rings selected from the group consisting of optionally substituted N-methylimidazole (Im), optionally substituted N-methylpyrrole (Py) and optionally substituted 3-hydroxy N-methylpyrrole (Hp); T 1 , T 2 and T 3 are the same or different and are each a linker group having the formula (2) —Y 1 -(A) n -Y 2 — (2) wherein Y 1 and Y 2 may be the same or different and are independently selected from NH, —NH 2 , C═O, C═S, C═NH, O, OH, S, SH, S(O), S(O) 2 , NR 3 , NHR 3 , N(R 3 ) 2 , an optionally substituted cycloalkylamine, an optionally substituted cycloalkyldiamine, and an optionally substituted heteroaryl group; where each R 3 is independently selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl; A is selected from the group consisting of an optionally substituted C 1-10 alkylene, an optionally substituted C 2-10 alkenylene, an optionally substituted C 2-10 alkynylene, an optionally substituted C 3-6 cycloalkylene, an optionally substituted C 6-10 aryl, C═O, C═S, and C═NH, NH, O, S, NH 2 , OH, SH, S(O), S(O) 2 , amino acids, and spermidine; and n is an integer selected from 1 to 20, wherein when n is an integer greater than 1, each (A) group may be the same or different; a is 0, or 1; b is an integer selected from 1, 2, 3, 4 and 5; wherein when b is an integer greater than 1, each P 1 , each T 2 and each M 2 may be the same or different; and c is 0, 1 or 2; wherein when c is 2, each P 2 may be the same or different and each T 3 may be the same or different; wherein said compound is selected from the group consisting of where n is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10, or a salt thereof.