Patent ID: 7615007

Claim:
A system for monitoring analyte concentration in a biological sample of a host, the system comprising: a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration; a flow control device configured to regulate exposure of the sensor to the biological sample and to the reference solution, wherein the flow control device is configured to intermittently expose the sensor to the biological sample and to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and to calibrate a signal associated with the biological sample therefrom, wherein the calibration information comprises steady state information and transient information, and wherein the transient information is obtained by processing a signal produced during exposure of the sensor to a step change in analyte concentration.