Patent ID: 8071752

Claim:
A multi-targeting siRNA that targets two different desired mRNA target sequences, wherein the siRNA comprises a first strand having a 5â€² terminus and a 3â€² terminus and a second strand having a 5 â€² terminus and a 3â€² terminus, wherein the first strand is 19-30 nucleotides in length, wherein the second strand is 19-30 nucleotides in length, wherein the first strand is perfectly complementary to a first desired mRNA target sequence, wherein the second strand is perfectly complementary to a second and different desired mRNA target sequence, wherein the first strand and second strand are not completely complementary and wherein the first strand and the second strand hybridize to form a double stranded siRNA, wherein the double stranded siRNA is a single duplex, wherein the first strand has the sequence 5â€² uagacacgcaaggagacaugccucuag 3â€² (SEQ ID NO:27) and the second strand has the sequence 5â€² cugggcuucuuuccuugggugaauaga 3â€² (SEQ ID NO:28).