Patent ID: 7402590

Claim:
A compound of formula I, salts and stereoisomers thereof: wherein X is O; Y is selected from the group consisting of O and S; Z is CH; R 1 is selected from the group consisting of hydrogen, optionally substituted substituent selected from the group consisting of C 1-6 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, aryl, heteroaryl, aryl(C 1-6 alkyl), heteroaryl(C 1-6 alkyl), heterocyclyl(C 1-6 alkyl), hydroxy(C 1-6 alkyl), amino(C 1-6 alkyl), and halo(C 1-6 alkyl); wherein the heteroaryl(C 1-6 alkyl) is selected from the group consisting of furan(C 1-6 alkyl), benzofuran(C 1-6 alkyl), thiophene(C 1-6 alkyl), benzothiophene(C 1-6 alkyl), pyrrole(C 1-6 alkyl), pyridine(C 1-6 alkyl), oxazole(C 1-6 alkyl), benzoxazole(C 1-6 alkyl), isoxazole(C 1-6 alkyl), benzisoxazole(C 1-6 alkyl), thiazole(C 1-6 alkyl), benzothiazole(C 1-6 alkyl), isothiazole(C 1-6 alkyl), imidazole(C 1-6 alkyl), benzimidazole(C 1-6 alkyl), pyrazole(C 1-6 alkyl), indazole(C 1-6 alkyl), tetrazole(C 1-6 alkyl), furazan(C 1-6 alkyl), 1,2,3-oxadiazole(C 1-6 alkyl), 1,2,3-thiadiazole(C 1-6 alkyl), 1,2,4-thiadiazole(C 1-6 alkyl), triazole(C 1-6 alkyl), benzotriazole(C 1-6 alkyl), quionoline(C 1-6 alkyl), isoquinoline(C 1-6 alkyl), pyridazine(C 1-6 alkyl), pyrimidine(C 1-6 alkyl), purine(C 1-6 alkyl), pyrazine(C 1-6 alkyl), pteridine(C 1-6 alkyl), pyrrole(C 1-6 alkyl), phenoxazole(C 1-6 alkyl), oxazole(C 1-6 alkyl), isoxazole(C 1-6 alkyl), oxadiazole(C 1-6 alkyl), benzopyrazole(C 1-6 alkyl), indazole(C 1-6 alkyl), quinolizine(C 1-6 alkyl), cinnoline(C 1-6 alkyl), phthalazine(C 1-6 alkyl), quinazoline(C 1-6 alkyl), and quinoxaline(C 1-6 alkyl); m is 0; R 4 is absent; R 5 and R 6 are independently an optionally substituted substituent selected from the group consisting of aryl(C 1-6 alkyl), heteroaryl(C 1-6 alkyl), and heterocyclyl(C 1-6 alkyl); R 2 and R 3 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and optionally substituted C 1-6 alkyl or selected such that R 2 and R 3 together form a ring system such that is selected front the group consisting of wherein R 7 and R 8 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and C 1-6 alkyl.