Patent ID: 7067554

Claim:
A compound comprising at least one moiety of the formula wherein L 1 is a C 1 –C 4 alkyl group and L 2 is a direct bond, and Aryl 1 and Aryl 2 are aryl, wherein each of Aryl 1 and Aryl 2 are substituted by at least one lipophilic group selected from the group consisting of a) —Y—C 16 alkyl; b) —Y-aryl; c) —Y—C- 1-6 alkylaryl; d) —Y—C 1-6 -alkyl-NR 7 R 8 ; e) —Y—C 1-6 -alkyl-W—R 20 ; wherein Y and W are, independently selected from the group consisting of —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH—, —O—CO—, and f) halogen, hydroxyl, cyano, carbamoyl, and carboxyl; wherein R 18 and R 19 are independently selected from the group consisting of aryl, C 1 –C 6 alkyl, C 1 –C 6 alkylaryl, C 1 –C 6 alkoxy, and C 1 –C 6 alkoxyaryl; R 20 is selected from the group consisting of aryl, C 1 –C 6 alkyl, and C 1 –C 6 alkylaryl; R 7 , R 8 , R 9 and R 10 are independently selected from the group consisting of hydrogen, aryl, C 1 –C 6 alkyl, and C 1 –C 6 alkylaryl; and wherein R 7 and R 8 may be taken together to form a ring having the formula —(CH 2 ) m —X—(CH 2 ) n bonded to the nitrogen atom to which R 7 and R 8 are attached, wherein m and n are, independently, 1, 2, 3, or 4; X is selected from the group consisting of —CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—, or a pharmaceutically acceptable salt thereof, wherein at least one of Aryl 1 and Aryl 2 is substituted with a lipophilic group of the formula —Y—C 1-6 -alkyl-NR 7 R 8 .