Patent ID: 8906678

Claim:
A method of isolating a human or mouse embryonic stem (ES) cells or induced pluripotent stem (iPS) cells in a heterogeneous sample containing human or mouse ES cells or iPS cells and cells that have undergone or are undergoing differentiation from human or mouse pluripotent ES cells or iPS cells, comprising: (a) obtaining a heterogeneous sample containing human or mouse ES cells or iPS cells and cells that have undergone or are undergoing differentiation from human or mouse pluripotent ES cells or iPS cells, (b) contacting the heterogeneous sample of step (a) with an antibody which binds prohibitin (PHB), (c) identifying ES iPS cells in the sample of step (b) which are bound to the PHB antibody; and (d) isolating the ES or iPS cells from step (c) that express PHB on their cell surface.