Patent ID: 6900297

Claim:
A compound which hybridizes with a nucleic acid and comprises a plurality of linked nucleosides, wherein: each nucleoside includes a pentofuranosyl sugar portion and a base portion; and at least one of said nucleosides bears at a 2′-O-position, a 3′-O-position, or a 5′-O-position of said pentofuranosyl sugar, a terminal substituent having formula: —R A —N(R 1a )(R 1b ) where: R A is alkyl having from 1 to about 10 carbon atoms or (CH 2 —CH 2 —Q) x ; R 1a and R 1b , independently, are H, R 2 , or an amine protecting group or have formula C(X)—R 2 , C(X)—R A —R 2 , C(X)—Q—R A —R 2 , C(X)—Q—R 2 ; and R 2 is a peptide; X is O or S; each Q is, independently, is NH, O, or S; and x is 1 to about 200.