Patent ID: 7098199

Claim:
A pharmaceutical composititon comprising a pharmaceutically acceptable carrier or diluent and a compound comprising a steroidal ring structure and a sulphamate group of the formula wherein each of R 1 and R 2 is independently selected from H, alkyl, alkenyl, cycloalky and aryl; wherein at least one of R 1 and R 2 is H; and wherein the compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); wherein if the sulphamate group on the compound were to be replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37° C. it would provide a K m value of less than 50 μM.