Patent ID: 6943187

Claim:
A pharmaceutical composition which comprises: (i) an effective amount of a compound of formula I or a pharmaceutically acceptable salt, ester, or solvate thereof, for treating alopecia or promoting hair growth in an animal in need thereof, wherein: R 1 is C 1 -C 9 straight or branched chain alkyl, C 2 -C 9 straight or branched chain alkenyl, C 3 -C 8 cycloalkyl, C 5 -C 7 cycloalkenyl or Ar 1 ; wherein said R 1 is unsubstituted or substituted with one or more substituents independently selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, C 5 -C 7 cycloalkenyl, hydroxy, and Ar 2 ; Ar 1 and Ar 2 are independently selected from the group consisting of 1-naphthyl, 2-naphthyl, 2-indolyl, 3-indolyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl and phenyl, wherein said Ar 1 is unsubstituted or substituted with one or more substituent(s) independently selected from the group consisting of hydrogen, halo, hydroxy, nitro, trifluoromethyl, C 1 -C 6 straight or branched chain alkyl, C 2 -C 6 straight or branched chain alkenyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyloxy, phenoxy, benzyloxy, and amino; X is O, S, CH 2 , or two hydrogen atoms; Y is O or NR 2 ; R 2 is hydrogen or C 1 -C 6 alkyl; Z is C 1 -C 6 straight or branched chain alkyl, or C 2 -C 6 straight or branched chain alkenyl, wherein said Z is substituted with one or more substituent(s) independently selected from the group consisting of Ar 1 , C 3 -C 8 cycloalkyl, C 1 -C 6 straight or branched chain alkyl substituted with C 3 -C 8 cycloalkyl, and C 2 -C 6 straight or branched chain alkenyl substituted with C 3 -C 8 cycloalkyl, or Z is the fragment wherein: R 3 is C 1 -C 9 straight or branched chain alkyl which is unsubstituted or substituted with C 3 -C 8 cycloalkyl or Ar 1 ; X 2 is O or NR 5 ; R 5 is selected from the group consisting of hydrogen, C 1 -C 6 straight or branched chain alkyl, and C 2 -C 6 straight or branched chain alkenyl; and R 4 is selected from the group consisting of phenyl, benzyl, C 1 -C 5 straight or branched chain alkyl, C 2 -C 5 straight or branched chain alkenyl, C 1 -C 5 straight or branched chain alkyl substituted with phenyl, and C 2 -C 5 straight or branched chain alkenyl substituted with phenyl; (ii) a hair revitalizing agent; and (iii) a pharmaceutically acceptable carrier.