Patent ID: 8455447

Claim:
A modified therapeutic agent comprising: (a) a therapeutic agent which is a soluble protein, wherein the soluble protein is a complement inhibitor; and (b) three or more membrane binding elements with low membrane affinity covalently associated with the therapeutic agent; wherein the membrane binding elements comprise at least two lipophilic elements that comprise myristoyl groups, and a basic amino acid sequence selected from the group consisting of: GSSKSPSKKDDKKGDC, [SEQ ID NO: 6] GSSKSPSKDKDKDGDC, [SEQ ID NO: 7] KSSKSPSKKDDKKPGDC, [SEQ ID NO: 8] KSSKSPSKDKDKDPGDC, [SEQ ID NO: 9] and KSKKKC, [SEQ ID NO: 10] wherein the membrane binding elements are capable of interacting independently and with thermodynamic additivity with components of cellular or artificial membranes exposed to extracellular fluids.