Patent ID: 7488754

Claim:
A method for treating and inhibiting the progression of polycystic kidney disease in a mammal in need thereof which comprises providing to said mammal an effective amount of a tumor necrosis factors-alpha converting enzyme (TACE) inhibitor compound wherein the TACE inhibitor compound is a compound of formula II: wherein R 6 is hydrogen or an optionally substituted substituent selected from phenyl, naphthyl, heteroaryl, alkyl of 1-6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms or C 5 -C 8 -cycloheteroalkyl, R 7 is H or alkyl of 1-6 carbon atoms and R 15 is alkyl of 1-6 carbon atoms or CH(CH 3 )OH.