Patent ID: 7064116

Claim:
A compound represented by Formula (I): including pharmaceutically acceptable esters, salts and acid addition salts thereof, wherein: R is one of hydrogen, amino, thio, sulfinyl, sulfonyl, sulfonamido, halogen, alkoxy, alkyl, alkenyl, or alkynyl and all R groups can be optionally substituted; R 1 is one of hydrogen, alkyl, alkenyl, arylkynyl, alkoxyalkyl, aminoalkyl, cyano, cyanoalkyl, thiocyanoalkyl, isothiocyano, azidoalkyl, arylalkyl, arylalkenyl, aryl, arylkylalkynyl, alkanoyloxyalkynyl, heteroaryloxyalkynyl, oxoalkynyl or a ketal thereof, cyanoalkynyl, heteroarylalkynyl, hydroxyalkynyl, alkoxyalkynyl, aminoalkynyl, acylaminoalkynyl, mercaptoalkynyl, hydroxyalkynyl dioic acid hemi-ester or a salt thereof, or alkynyloxyalkynyl and all R 1 groups can be optionally substituted; R 2 is one of hydroxyl, alkoxy, alkanoyloxy, aminocarbonyloxy, alkoxycarbonyloxy; azido, or NCS; R 3 is hydrogen, or when a double bond is present between C4 and C5 of the steroid ring system, then R 3 is not present; R 4 is one of hydrogen or lower alkyl, R 5 is one of —CH(OR 6 )R 7 , —C≡C-aryl, —C≡C—CH(OR 6 )R 8 , or —C≡C—C(O)R 8 ; R 6 is independently H, optionally substituted C 1-10 alkyl, optionally substituted C 2-10 alkenyl, optionally substituted C 2-10 alkynyl, optionally substituted aryl, optionally substituted arylkyl, optionally substituted C(O)—C 1-10 alkyl, optionally substituted C(O)—C 2-10 alkenyl, optionally substituted C(O)—C 2-10 alkynyl R 7 is independently allene, optionally substituted alkynyl, optionally substituted arylkylalkynyl, optionally substituted alkanoyloxyalkynyl, optionally substituted heteroaryloxyalkynyl, oxoalkynyl or a ketal thereof, cyanoalkynyl, hydroxyalkynyl, alkoxyalkynyl, aminoalkynyl, acylaminoalkynyl, mercaptoalkynyl, hydroxyalkynyl dioic acid hemi-ester or a salt thereof, or alkynyloxyalkynyl; R 8 is independently H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, arylalkyl, aryl, all of which may be optionally substituted; and the dotted lines indicate that a single or double bond may be present.