Patent ID: 8501747

Claim:
The compound represented by the structural Formula Ia or a pharmaceutically acceptable salt thereof, wherein: (i) “w” and “z” are 0, “n” is 1, A is a compound of the formula: J 1 is CH, J 2 , and J 3 are —C(R 2 )—; J is N; J 5 is CH; R 4 and R 4′ are —H; providing a compound represented by the Formula: wherein R 2 is independently for each occurrence —H or —CH 3 ; and R 1 is a ring which is: wherein R 5a is —H, —CH 3 , —(CH 2 )—CH 3 , —(CH 2 ) 2 —CH 3 , —CH—(CH 3 ) 2 , —(CH 2 ) 2 —O—CH 3 , —CH 2 —CN, or —(CH 2 ) 2 —CN; or or wherein R 11a is independently —H or —CH 3 , or or wherein R 6a is independently —H, CH 3 , —CH 2 —CH 3 , or —(CH 2 —) 2 —CH 3 and R 7a is independently, —H, —CH 3 , —CF 3 ; or wherein R 8a is independently for each occurrence: —H, or —CH 3 ; or wherein R 8a′ is independently for each occurrence: —H; —NH 2 ; —CH 3 ; —(CH)—(CH 3 ) 2 ; —NH—CH 3 ; —NH—(CH 2 )—CH 3 ; —NH-cyclopropyl-O—CH 3 ; or —O-benzyl; or or wherein R 9a is independently for each occurrence: —H; —CH 3 , —O—CH 3 ; —O—(CH 2 ) 3 —N(CH 3 ) 2 ; or wherein: (i) each R 2b is —H and R 1b is independently —H, —CH 3 , —CH 2 —CH 3 , —CF 3 , —Cl; —F; (ii) (i) each R 2b is —H, two of R 1b are —H and one of R 1b is -phenyl, —O—CF 3 , —CN, —O-benzyl, —S(O) 2 —CH 3 , —NH—S(O) 2 —CH 3 , —S(O) 2 —NH 2 , —S(O)—CH 3 , —C(O)—NH 2 ; or (iii) one of R 2b is —F or —CH 3 , one of R 1b is —CH 3 , —O-phenyl, —C(O)—OH, —OH, or —F, and the others of R 1b and R 2b are —H; or or (ii) “w” and “z” are 0, “n” is 2, A is a compound of the formula: J 1 , J 2 , and J 3 are —CH—; J is —CH 2 —; J 5 is —O—; R 4 and R 4′ are —H; R 1 is a compound of the Formula: to yield a compound of the Formula: or (iii) “w” and “z” are 0, “n” is 2, A is a compound of the formula: J, J 1 , J 2 , and J 3 are —CH—; R 4 is —H, R 4′ is not there; and atoms 1 and 2 form a double bond; to yield a compound of the Formula: wherein: J 5 is —CH 2 — or —O—; and R 1 is: (a) -phenyl; wherein, for each occurrence, R 6b is independently —H or —CH 3 ; wherein R 8b is independently for each occurrence: —H, or —CH 3 ; or or (iv) “w” and “z” are 0, “n” is 1, A is a compound of the formula: J, J 1 , J 2 , and J 3 are —CH—; J 5 is CH 2 ; R 4 is —H, R 4′ is not there; and atoms 1 and 2 form a double bond; thereby providing a compound of the Formula: wherein: R 1 is: wherein, for each occurrence, R 8b is independently —H or —CH 3 ; wherein R 10b is independently, —H, —CH 3 , —CH 2 —CH 3 , —CF 3 , —S(O) 2 —CH 3 , or —NH—C(O)—CH 3 .