Patent ID: 7544677

Claim:
A compound of the Formula B-1: wherein: a is 0 or 1; b is 0 or 1; m is 0, 1 or 2; Q is selected from: which may be optionally substituted with one or more substituents selected from: heterocyclyl, aryl, (C 3 -C 8 )cycloalkyl, O a (C 1 -C 6 )alkyl, OH, N(R b ) 2 , O—N(R b ) 2 , oxo and halogen, said heterocyclyl, aryl, cycloalkyl and alkyl optionally substituted with 1 to 3 substituents selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-OH, O(C 1 -C 6 )alkyl oxo, OH, N(R b ) 2 and halogen; R 1 is selected from: heterocyclyl, said heterocyclyl optionally substituted with R 10 ; R 10 is selected from: H, (C═O) a O b C 1 -C 10 alkyl, (C═O) a O b aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, (C═O) a O b heterocyclyl, CO 2 H, halo, CN, OH, O b C 1 -C 6 perfluoroalkyl, O a (C═O) b NR 12 R 13 , oxo, CHO, S(O) m NR 12 R 13 , SH, S(O) m —(C 1 -C 10 )alkyl or (C═O) a O b C 3 -C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 11 ; R 11 is selected from: (C═O) a O b (C 1 -C 10 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, (C 0 -C 6 )alkylene-S(O) m R a , oxo, OH, halo, CN, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 0 -C 6 )alkylene-aryl, (C 0 -C 6 )alkylene-heterocyclyl, (C 0 -C 6 )alkylene-N(R b ) 2 , C(O)R a , (C 0 -C 6 )alkylene-CO 2 R a , C(O)H, and (C 0 -C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b ) 2 ; R 12 and R 13 are independently selected from: H, (C═O)O b C 1 -C 10 alkyl, (C═O)O b C 3 -C 8 cycloalkyl, (C═O)O b aryl, (C═O)O b heterocyclyl, C 1 -C 10 alkyl, aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, heterocyclyl, C 3 -C 8 cycloalkyl, SO 2 R a , and (C═O) a NR b 2 , said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 11 , or R 12 and R 13 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 3-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 11 ; R a is H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and R b is H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O)OC 1 -C 6 alkyl, (C═O)C 1 -C 6 alkyl or S(O) m R a ; or a pharmaceutically acceptable salt or a stereoisomer thereof.