Patent ID: 8513269

Claim:
A topical formulation, comprising a compound represented by the formula (I), or salt thereof: wherein R represents hydroxyl, C 1-6 alkoxy optionally substituted with C 1-6 alkoxy, or amino optionally substituted with C 1-6 alkyl, one or more solvents selected from the group consisting of polyethylene glycol having a molecular weight of 200 to 600, dipropylene glycol, benzyl alcohol, polyoxyethylene sorbitan fatty acid ester, diethylene glycol monoethyl ether, propylene glycol, polyoxyethylene oleyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene lauryl ether, polyoxyethylene castor oil, and oleic acid, one or more bases selected from the group consisting of petrolatum, paraffin, liquid paraffin, microcrystalline wax, carunauba wax, and white beeswax one or more absorption enhancers selected from the group consisting of isopropyl myristate, ethyl myristate, octyldodecyl myristate, isopropyl palmitate, isostearyl palmitate, isopropyl isostearate, butyl stearate, ethyl oleate, decyl oleate, diisopropyl sebacate, diethyl sebacate, diisopropyl adipate, diethyl adipate, and diethyl phthalate, two or more bleeding preventing agents selected from the group consisting of polyethylene glycol having a molecular weight of 1000 to 50000, polyoxyethylene hydrogenated castor oil, stearic acid, oleic acid, sorbitan monostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, and glycerol esters of fatty acids, and water.