Patent ID: 6939947

Claim:
A method of treating a bacterial infection in a host comprising the step of administering to the host an effective amount of at least one compound of the formula wherein R 1 represents alkanoyl of C 2 -C 10 which is unsubstituted, or which is substituted by a phenyl, or which is substituted on other than the alpha-carbon atom by an amino or protected amino group; benzoyl or substituted benzoyl bearing one or two substituents each of which is independently halo, lower alkyl of C 1 -C 4 , lower alkoxy of C 1 -C 4 or phenyl; an acyl derived from an alpha-amino acid or an acyl derived from a protected alpha-amino acid, said alpha-amino acid being selected from the group consisting of: alanine, arginine, asparagine, aspartic acids cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, 3-phenylalanine, 3-(p-chlorophenyl)alanine, proline, serine, threonine, tryptophan and valine, in either D- or L-form; or an acyl derived from an alpha-amino acid as defined above which bears on the amine a substituent which is alkyl of C 1 -C 10 , benzyl, phenylbenzyl, or p-chlorobenzyl, with the proviso that the acyl derived from N-methyl-D-leucine is excluded; R 2 represents hydrogen or an epivancosaminyl of the formula wherein R 2a represents hydrogen or —CH 2 —R 3 and R 3 represents hydrogen, alkyl of C 1 -C 11 , alkyl of C 1 -C 11 —R 4 , or R 4 -(linker (0 or 1) -R 4 ) 0 or 1 , wherein each R 4 is independently phenyl or phenyl substituted by one or two substituents, each of which is independently halo, lower alkyl of C 1 -C 8 , lower alkoxy of C 1 -C 8 , lower alkylthio of C 1 -C 4 , or trifluoromethyl, and “linker” is —O—, —CH 2 —, or —O—(CH 2 )n- wherein n is 1-3.