Patent ID: 7790150

Claim:
A conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure: wherein: each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; the modifier M is directly or indirectly attached to a linker L M through an amide bond; the carrier is a polyacetal or polyketal and is linked directly or indirectly to each occurrence of a linker L M through an ester bond; denotes direct or indirect attachment of M to linker L M ; and each occurrence of a linker L M independently comprises a moiety having the structure: wherein: denotes the site of attachment to the modifier M; p is an integer from 1-12; q is an integer from 0-4; R 1 is hydrogen, —C(═O)R 1A , —C(═O)OR 1A , —SR 1A , SO 2 R 1A or an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, heteroaryl, aromatic, heteroaromatic moiety, wherein each occurrence of R 1A is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, heteroaliphatic, heteroalicyclic, aromatic, heteroaromatic, aryl or heteroaryl; and each occurrence of R and R 2 is independently hydrogen, halogen, —CN, NO 2 , an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, heteroaryl, aromatic, heteroaromatic moiety, or -GR G1 wherein G is —O—, —S—, —NR G2 —, —C(═O)—, —S(═O)—, —SO 2 —, —C(═O)O—, —C(═O)NR G2 —, —OC(═O)—, —NR G2 C(═O)—, —OC(═O)O—, —OC(═O)NR G2 —, —NR G2 C(═O)O—, —NR G2 C(═O)NR G2 —, —C(═S)—, —C(═S)S—, —SC(═S)—, —SC(═S)S—, —C(═NR G2 )—, —C(═NR G2 )O—, —C(═NR G2 )NR G3 —, —OC(═NR G2 )—NR G2 C(═NR G3 )—, —NR G2 SO 2 —, —NR G2 SO 2 NR G3 —, or —SO 2 NR G2 —, wherein each occurrence of R G1 , R G2 and R G3 is independently hydrogen, halogen, or an optionally substituted aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, aromatic, heteroaromatic, aryl or heteroaryl moiety.