Patent ID: 7528162

Claim:
A 4,5-dihydro-1H-pyrazole compound of formula (I), a tautomer, or a stereoisomer thereof, or a hydrochloric acid salt of any of the foregoing: wherein: R is chosen from a 4-chlorophenyl group, a 4-fluorophenyl group, and a 5-chlorothien-2-yl group, R 1 is chosen from a phenyl group, a 2-fluorophenyl group, a 3-fluorophenyl group, a 3-(trifluoromethyl)phenyl group, and a 2,6-difluorophenyl group; R 2 is a hydrogen atom; R 3 is chosen from a hydrogen atom, a methyl group, and an ethyl group; R 4 is a group chosen from (N-methylpyrrolidin-2-yl)methyl, (N-methylpyrrolidin-3-yl)methyl, 2-(acetoxy)ethyl, 2-(diethylamino)ethoxy, 2-(dimethylamino)ethoxy, 2-(dimethylamino)ethyl, 2-(ethylamino)ethyl, 2-(methoxy)ethyl, 2-(methylamino)ethyl, 2-(morpholin-4-yl)ethyl, 2-(piperidin-1-yl)ethyl, 2-(pyrrolidin-1-yl)ethyl, 2,2,2-trifluoro-ethylamino, 2,6-difluorophenyl, 2-aminoethyl, 2-aminoxyethyl, 2-fluoroethyl, 2-hydroxy-2-methylpropyl, 2-hydroxyethyl, 2-propoxy, 3-(1H-imidazol-1-yl)propyl, 3-(dimethylamino)-2-methylprop-2-yl, 3-(dimethylamino)propyl, 3-(morpholin-4-yl)-propyl, 3-fluorophenyl, 3-hydroxypropyl, 4-(pyrrolidin-1-yl)butyl, azepan-1-yl, cis/trans-2,6-dimethylpiperidin-1-yl, hydroxyl, methoxy, morpholin-4-yl, N-methylpiperidin-4-yl, piperidin-1-yl, pyrrolidin-1-yl, and t-butoxy, or, R 3 and R 4 together with the nitrogen atom to which they are bonded form a group chosen from [1,4′]-bipiperidin-1′-yl, 1,1-dioxythiomorpholin-4-yl, 1,2,3,4-tetrahydro-isoquinolin-2-yl, 1,4-diazepan-1-yl, 2,6-cis-dimethyl-4-methylpiperazin-1-yl, 2,6-cis-dimethylpiperazin-1-yl, 3,5-cis-dimethylpiperazin-1-yl, 3-hydroxypiperidin-1-yl, 4-(2-dimethylaminoethyl)piperazin-1-yl, 4-(3-dimethylaminopropyl)piperazin-1-yl, 4-(3-hydroxypropyl)piperazin-1-yl, 4-(dimethylamino)piperidin-1-yl, 4-(hydroxymethyl)-piperidin-1-yl, 4-(pyridin-4-yl)piperazin-1-yl, 4-hydroxypiperidin-1-yl, 4-methyl-1,4-diaze-pan-1-yl, 4-methylpiperazin-1-yl, azetidin-1-yl, morpholin-4-yl, and piperazin-1-yl; and R 5 is chosen from: benzyl, phenyl, thienyl and pyridyl groups, wherein the benzyl, phenyl, thienyl, and pyridyl groups are optionally substituted with 1, 2, 3 or 4 independently chosen substituents Y, which are the same or different, wherein Y is chosen from C 1-3 -alkyl, C 1-3 -alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, mono-(C 1-2 )-amino, dialkyl-(C 1-2 )-amino, mono-(C 1-2 )-amido, dialkyl-(C 1-2 )-amido, C 1-3 -alkyl sulfonyl, dimethylsulfamido, C 1-3 -alkoxycarbonyl, carboxyl trifluoromethylsulfonyl, cyano, carbamoyl, sulfamoyl, and acetyl groups; C 1-8 branched and unbranched alkyl, C 3-8 -alkenyl, C 3-10 -cycloalkyl, C 5-10 -bicycloalkyl, C 6-10 -tricycloalkyl, and C 5-8 -cycloalkenyl groups; and a naphthyl group.