Patent ID: 8475782

Claim:
A method for treating at least a surface of a substrate containing labile hydrogen atoms to confer cytotoxic properties or cell-adhesion properties, the method comprising exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof, and wherein: the reactive site for promoting the attachment of said copolymer to a substrate is included in monomer of type A under the following formula wherein □ means the link to monomer A m is 0 or 1, X 1 represents an amine, an amide or a ketone function, an oligoethylene glycol, an arylene group, a (C 1 -C 6 )alkylarylene, or a (C 1 -C 8 )alkylene which may be interrupted by any one of an amine, an amide or a ketone function, one of the carbon atom in the (C 1 -C 8 )alkylene being optionally replaced by a quaternary ammonium, a quaternary phosphonium a (C 1 -C 4 )alkylpyridinium, a (C 1 -C 4 )alkylimidazolium or a guanidinium group, at least one of R 1 , R 2 and R 3 is able to react with an hydroxyl, a thiol or an amine group, and the other one or two radicals chosen among R 1 , R 2 and R 3 independently represent a (C 1 -C 4 )alkoxy, or any one of the group R 1 , R 2 and R 3 is a group showing a character of leaving group or alternatively represents a part of monomer unit containing a 5- or 6-membered saturated ring containing a quaternary ammonium.