Patent ID: 7943178

Claim:
A method for delivering a peptide to a patient in need thereof, comprising administering to said patient a delivery formulation for said peptide comprising an effective amount of said peptide complexed with a diketopiperazine derivative, wherein said delivery formulation is prepared by complexing said peptide with microparticles of said diketopiperazine derivative by the steps of: a) providing pre-formed microparticles of diketopiperazine in a suspension comprising a solvent; b) adding said peptide to said suspension; and c) removing solvent from said suspension; wherein said diketopiperazine derivative has the formula 2,5-diketo-3,6-di(4-X-aminobutyl)piperazine, wherein X is selected from the group consisting of fumaryl, succinyl, maleyl, and glutaryl, and wherein said microparticles release said peptide upon dissociation.