Patent ID: 8580512

Claim:
A method of identifying a test compound characterized by reducing rotenone inhibition of proliferation of a strain of a yeast Schizosaccharomyces pombe , comprising: (a) obtaining a culture of a strain of the yeast, wherein the proliferation of the yeast when in contact with rotenone is reduced compared to the proliferation of the yeast when not in contact with rotenone; (b) contacting the yeast in contact with rotenone with a test compound; and (c) determining whether the proliferation of the yeast in contact with rotenone and with the test compound increases compared to the proliferation of the yeast in contact with rotenone but not with the test compound, thereby indicating whether the test compound reduces inhibition of yeast proliferation by rotenone, wherein the Schizosaccharomyces pombe is maintained under culture conditions comprising a limited nutrient minimal medium and/or comprises a mutation of at least one gene, said mutation conferring sensitivity of the yeast to proliferative inhibition by rotenone, wherein the at least one gene is aks1, pmk1, or psd1, psd2 and psd3.