Patent ID: 7160854

Claim:
A compound of the formula (I): wherein A is a 2,2′-dimethoxy-1,1′-binapthyl group or a 1,1′-binapthyl group; X and Z are at the 3 and 3′ positions of the binapthyl group, respectively or at the 2 and 2′ positions of the binapthyl group respectively; Q is hydrogen, C 1 –C 12 straight chain, branched or cyclic alkyl substituted with one or more hydroxy groups, or a mono- or di-saccharide moiety; Z is —CR 10 R 11 —, —NR 12 —, —C(O)O—, —C(O)NR 12 — or —O—, where R 10 and R 11 are independently selected from hydrogen, hydroxy, C 1 –C 6 alkyl, C 6 –C 10 aryl, C 1 –C 6 alkoxy and —N(R 13 ) 2 and where each R 13 is independently selected from hydrogen and C 1 –C 6 alkyl, and where R 12 is selected from hydrogen and C 1 –C 6 alkyl; R 1 is selected from hydrogen, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, —N(R 13 ) 2 and —N(R 12 )—COR 14 ; where R 12 and R 13 are as defined above, and where R 14 is selected from hydrogen, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy and —NR 12 ; R 2 is selected from hydrogen, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, —N(R 13 ) 2 and —N(R 12 )—COCHR 2a R 2b ; where R 2a and R 2b are selected from hydrogen, hydroxy, C 1 –C 6 alkyl, C 1 -–C 6 alkoxy, —N(R 13 ) 2 and —N(R 12 )—COR 14 ; where R 12 , R 13 and R 14 are as defined above; R 3 , R 4 and R 5 are independently selected from hydrogen, C 1 –C 6 alkyl and α side chains of α-amino acids; R 6 is —CO 2 R 15 , —CONHR 16 , —CONHOR 16 , —CONHNHR 16 , —SO 2 N(R 16 ) 2 , —SO 2 R 17 or —P(O)(OR 18 )(OR 18 ) where each R 15 , R 16 , R 17 and R 18 is independently selected from hydrogen, C 1 –C 6 alkyl, C 3 –C 7 cycloalkyl, C 6 –C 10 aryl and C 7 –C 10 arylalkyl; B is an α-amino acid residue, a β-amino acid residue or an α,α-disubstituted amino acid residue, such residue forming amide linkages with the adjacent molecules; W is —O— or CR 10 R 11 where R 10 and R 11 are as defined above; Y is an optionally substituted amino group, a moiety containing an optionally substituted amino group or a salt thereof; is a single or double bond; R 7 and R 8a are hydrogen or are absent if is a double bond; and R 8b and R 9 are hydrogen, and X is selected from (CR 10 R 11 ) u , —(CR 10 R 11 ) u —CH═CH—, —NR 12 (CR 10 R 11 ) u —, —(CR 10 R 11 ) u NR 12 , —O(CR 10 R 11 ) u —, —(CR 10 R 11 ) u O— or —O(CR 10 R 11 )CH═CH— where R 10 , R 11 and R 12 are as defined above; or R 8b and R 9 together form a covalent bond between X and the carbon to which R 8b is attached, and X is selected from (CR 10 R 11 ) x , —NR 12 (CR 10 R 11 ) x —, —(CR 10 R 11 ) x NR 12 —, —O(CR 10 R 11 ) x — or —(CR 10 R 11 ) x O—, where R 10 , R 11 and R 12 are as defined above; n, m, r and t are independently selected from 0 or 1; s is an integer selected from 0 to 3; p is an integer selected from 0 to 6, provided that when W is —O—, p is at least 1; and u, x and q are independently selected from 0 to 4; or a pharmaceutically acceptable salt thereof.