Patent ID: 8008449

Claim:
An isolated human monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody or antigen-binding portion thereof cross-competes for binding to PD-1 with a reference antibody or reference antigen-binding portion thereof comprising: a) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 1 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 8; b) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 2 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 9; c) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 3 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 10; d) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 4 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 11; e) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 5 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 12; f) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 6 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 13; or g) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 7 and a human light chain variable region comprising amino acids having the sequence set forth in SEO ID NO: 14.