Patent ID: 8497275

Claim:
A compound or salt thereof, wherein: the compound corresponds in structure to any one of formulae (I-5) and (I-6): R A is selected from the group consisting of alkylcarbonyl, alkyloxycarbonyl, carbocyclylcarbonyl, carbocyclyloxycarbonyl, aminoalkylcarbonyl, carbocyclylaminocarbonyl, carbocyclylalkyloxycarbonyl, and alkylcarbocyclylsulfonyl, wherein: the amino portion of the aminoalkylcarbonyl optionally is substituted with carbocyclylalkyloxycarbonyl; R 1 is pyrizinyl; R 2 is an optionally substituted carbocyclyl; R 3 is selected from the group consisting of hydrogen, alkyl, carbocyclylalkylaminocarbonylalkyl, and carbocyclyl; R 4 is selected from the group consisting hydrogen and alkyl; R 5 is selected from the group consisting of hydrogen, alkyl and carbocyclylalkyl; R 6 is hydrogen; R 7 is hydrogen; R 8 is aminocarbonyl optionally substituted with R B ; each R B is independently selected from the group consisting of aminocarbonylalkyl and carbocyclyl, wherein: the amino portion of the aminocarbonylalkyl optionally is substituted with one or two substituents independently selected from the group consisting of alkyl, wherein: the alkyl optionally is substituted one or more substituents independently selected from the group consisting of alkyloxy, carbocyclyl, heterocyclyl, and aminocarbonyl, wherein: the carbocyclyl and heterocyclyl optionally are substituted with one or more substituents independently selected from the group consisting of halo, alkyl and alkyloxy, and the aminocarbonyl optionally is substituted with one or two independently selected alkyl.