Patent ID: 7605160

Claim:
A compound of the formula I wherein: R 1 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl or —CONR 4 R 5 ; R 2 is hydrogen or C 1 -C 4 alkyl; R 3 is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, —CONHR 4 , —CONHSO 2 R 4 , —(CH 2 ) n -aryl, —(CH 2 ) n -substituted aryl, —(CH 2 ) n -heteroaryl, —(CH 2 ) n -substituted heteroaryl, —(CHR 4 ) n CONHalkyl, —(CHR 4 ) n CONHsubstituted aryl, —(CHR 4 ) n CONH heteroaryl, —(CHR 4 ) n CONHsubstituted heteroaryl, —(CHR 4 ) n CONH(CH 2 ) n , —OH, —(CH 2 ) 2 (CH 2 ) n —OH, —(CH 2 ) 2 (CH 2 ) n —NH 2 or —(CH 2 ) 2 (CH 2 ) n —S-alkyl, two of which may be attached to the same ring carbon atom; R 4 and R 5 are independently hydrogen, C 1 -C 4 alkyl or phenyl; R 6 and R 7 are independently hydrogen, C 1 -C 4 alkyl, halogen, cyano, amino or substituted amino; R 8 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 1 -C 5 arylalkyl or C 4 -C 8 heterocyclyl with at least one atom on the ring selected from a nitrogen or oxygen atom, and each of said R 8 groups optionally substituted with 1 to 3 groups selected from the group consisting of —OH, OR 9 , —NH 2 , —NR 9 R 10 , —CONHR 9 , —OCONHR 9 , —CONHSO 2 R 9 , —NHCONHR 9 , —SR 9 , —S(═O)R 9 , —SO 2 R 9 and —SO 2 NR 9 R 10 ; R 9 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, an optionally substituted aryl or heteroaryl group; said substituents on the substituted aryl or substituted heteroaryl group are one or more hydrogen, halogen, alkyl, substituted alkyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxy or substituted aryloxy; R 10 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl or C 1 -C 6 alkoxy; n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.