Patent ID: 7544798

Claim:
A process for preparing a compound of the following formula (I), or a pharmaceutically acceptable salt or ester thereof: wherein Q is a substituent of the following formula: the olefin group attached to the cyclopropyl ring is in the configuration syn to the A group as represented by the following structure: W is N; L 0 is selected from H, —OH, —OCH 3 and —N(CH 3 ) 2 ; one of L 1 and L 2 is —CH 3 , —F, —Cl or —Br and the other of L 1 and L 2 is H, or both L 1 and L 2 are H; R 2 is wherein R 6 is NH—R 7 or NH—C(O)—R 7 , wherein R 7 is independently: C 1-6 alkyl, or C 3-6 cycloalkyl; R 3 is NH—C(O)—OR 10 , wherein R 10 is C 1-6 alkyl, or C 3-6 cycloalkyl; R 4 is H or C 1-6 alkyl; D is a 5-atom saturated alkylene chain; and A is a carboxyl group, said process comprising the step of cyclyzing a diene compound of formula (IX) in the presence of a suitable catalyst to obtain a compound of the formula (I): and when A is a protected carboxylic acid group, optionally subjecting the compound of formula (I) to deprotection (e.g., hydrolysis) conditions to obtain a compound of formula (I) wherein A is a carboxylic acid group; and when A is a carboxyl group in the resulting compound of formula (I), optionally coupling this compound with a sulfonamide of formula R 11A SO 2 NH 2 , in which R 11A is C 1-8 -alkyl, C 3-7 -cycloalkyl or C 1-6 -alkyl-C 3-7 -cycloalkyl, in the presence of a suitable coupling agent to obtain a compound of formula (I) wherein A is -C(O)—NH—SO 2 R 11A .