Patent ID: 6936584

Claim:
A compound of the formula: X 1 -X 2 -X 3 -Leu-X 4 -Glu-Leu-X 5 -X 6 -Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-X 7 -Z 3 [SEQ.ID.NO.27] wherein: (a) X 1 is (i) a group of two amino acid residues selected from the group consisting of Leu-Leu, Val-Leu, Ile-Leu, tert-Leu-Leu, Nle-Leu, and Ala-Thr, and N-acylated derivatives thereof; or (ii) the group Z 1 -Ser-Thr-Z 2 -Val-Leu [SEQ.ID.NO. 28] wherein Z 1 is an amino acid residue selected from the group consisting of Leu, Val, Ile, tert-Leu, Nva, Abu, and Nle or an N-acylated derivative thereof or Z 1 is an alkanoyl group; and Z 2 is a amino acid residue selected from the group consisting of Ala, Ser, Cys, and Thr; (b) X 2 is an amino acid residue selected from the group consisting of Gly, Glu, Asn or Aib; (c) X 3 is an amino acid residue selected from the group consisting of Arg, Orn, Lys and ε-amidated derivatives thereof; (d) X 4 is a group of two amino acid residues selected from the group consisting of Ser-Gln, Thr-Gln, Ala-Asn and Thr-Asn; (e) X 5 is an amino acid residue selected from the group consisting of His, Aib, Ile, Leu and Val; (f) X 6 is an amino acid residue selected from the group consisting of Arg, Orn and Lys and ε-amidated derivatives thereof; (g) X 7 is a group having 6 amino acid residues selected from the group consisting of (i) Thr-Gly-Ser-Asn-Thr-Tyr [SEQ.ID.NO. 29]; (ii) Thr-Gly-Ser-Gly-Thr-Pro [SEQ.ID.NO. 30]; (iii) Val-Gly-Ser-Asn-Thr-Tyr [SEQ.ID.NO. 31]; (iv) Val-Gly-Ser-Gly-Thr-Pro [SEQ.ID.NO. 32]; and (h) Z a is OH or NH 2 ; with the proviso that the compound does not have the formula of any of SEQ. ID. NOS. 14 to 26; and pharmaceutically acceptable salts thereof.