Patent ID: 7759116

Claim:
An MVA virus vector comprising an expression cassette; wherein the expression cassette comprises a transcriptional regulatory element and a sequence that encodes an entire Flavivirus NS1 protein of Dengue virus serotype 2 or a part thereof; wherein the MVA is MVA-BN deposited under ECACC V00083008 or an MVA capable of reproductive replication in chicken embryo fibroblasts (CEF) and the Baby Hamster kidney cell line BHK, but not capable of reproductive replication in vitro in the human keratinocyte cell line HaCaT or the human cervix adenocarcinoma cell line HeLa; and wherein the MVA virus vector induces an immune response against one or more Flavivirus, selected from Dengue virus serotype 1, Dengue virus serotype 3, Dengue virus serotype 4, Japanese Encephalitis virus, and West Nile virus, when the MVA virus vector is administered to an animal.