Patent ID: 7132444

Claim:
A process for the preparation of trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide, a compound of the formula 1, comprising, a) reacting 3-Ethyl-4-methyl-3-pyrrolidin-2-one with a compound of formula 2, to obtain a compound of formula 3, b) reacting a compound of formula 3 with 4-(2-Aminoethyl)benzene sulfonamide to obtain 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido)ethyl]benzene sulfonamide, a compound of formula 4, c) and further reacting the compound of formula 4 with trans-4-methylcyclohexyl isocyanate to obtain the compound of formula 1, wherein, X is halogen, nitroaryl or haloaryl, Z is O, and R is aryl, where aryl radical is unsubstituted or substituted by one or more radicals from the group consisting of nitro, halogen, cyano, azido, haloalkyl, CO—R 1 , SR 2 , SO—R 3 and SO 2 —R 4 , R 1 is H, C 1 –C 5 -alkyl, C 2 –C 5 -alkenyl, C 2 –C 5 -alkynyl, C 1 –C 5 -alkoxy or C 2 –C 5 -alkenoxy, R 2 is C 1 –C 5 -alkyl, C 2 –C 5 -alkenyl, C 2 –C 5 -alkynyl, C 1 –C 5 -haloalkyl or C 2 –C 5 -haloalkenyl, R 3 is C 1 –C 5 -alkyl, C 2 –C 5 -alkenyl, C 2 –C 5 -alkynyl, C 1 –C 5 -haloalkyl or C 2 –C 5 -haloalkenyl, R 4 is C 1 –C 5 -alkyl, C 2 –C 5 alkenyl, C 2 –C 5 -alkynyl, C 1 –C 5 -haloalkyl or C 2 –C 5 -haloalkenyl.