Patent ID: 7459303

Claim:
A device for monitoring the migration or invasion of a biological particle such as a cell, which device comprises: a) an upper chamber adapted to receive and retain a cell sample; b) a lower chamber comprising at least two electrodes; and, c) a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough from said upper chamber to said lower chamber, wherein said membrane is disposed in the device so as to separate the upper and lower chambers from one another, wherein said at least two electrodes are disposed on said membrane and are partially exposed through pores of said porous membrane; wherein migration of cells through the porous membrane permits attachment of cells that have migrated to said lower chamber on one or more of at least two electrodes of said lower chamber, wherein said at least two electrodes have substantially the same surface area, and further wherein said attachment at any one or more of said at least two electrodes provides a detectable change in impedance between or among the electrodes.