Patent ID: 8143268

Claim:
A compound of Formula II or a pharmaceutically acceptable salt thereof wherein: X is selected from the group consisting of O and S; Y is selected from the group consisting of O and S; R 1 is 0-3 substituents each of which is independently selected from the group consisting of CN, C 1-10 alkyl, C 2-10 alkenyl, C 1-10 alkylPO 3 H 2 , —O—C 1-10 alkyl, C 1-10 alkylNR 3 R 4 , —O—C 1-10 alkylNR 3 R 4 , halo, NR 3 R 4 , alkylaryl, alkylheteroaryl, aryl, heteroaryl, —O-alkylaryl, SO 2 NR 3 R 4 ; R 3 and R 4 are each independently selected from the group consisting of hydrogen, CO 2 C 1-4 alkyl, C(O)C 1-4 alkyl, C 1-10 alkyl, C 1-10 NR 5 R 6 , —NH(CO)(CO)NHC 1-4 alkyl; or R 3 and R 4 taken together with the attached nitrogen form a 5-7 membered heterocyclic ring which contains zero to two additional heteroatoms selected from N, O or S where S can be at the S, S(O) or S(O) 2 oxidation state and wherein said heterocyclic ring is optionally substituted at the carbon or nitrogen atoms with one or more substituents selected from halo, aryl, C(O)C 1-4 alkyl, SO 2 C 1-4 alkyl, SO 2 H, C 1-4 alkyl, CO 2 H, CO 2 H, C 1-4 alkyl, NR 5 R 6 , C 1-4 alkylNR 5 R 6 ; R 5 and R 6 are each independently selected from the group consisting of H, and C 1-4 alkyl or R 5 and R 6 together with the attached nitrogen form a 5-7 membered heterocyclic ring which contains zero to two additional heteroatoms selected from N, O or S where S can be at the S, S(O) or S(O) 2 oxidation state and wherein said heterocyclic ring is optionally substituted at the carbon or nitrogen atoms with one or more substituents selected from halo and C 1-4 alkyl; when R 1 is alkylaryl or —O-alkylaryl, the aryl group of said alkylaryl substituent is optionally substituted with a substituent selected from C 1-10 alkyl, —O—C 1-10 alkyl, C 1-10 alkylNR 3 R 4 , —O—C 1-10 alkylNR 3 R 4 , halo, NR 3 R 4 , alkylaryl, —O-alkylaryl, SO 2 NR 3 R 4 B is absent; C is absent; R 2 is selected from the group consisting of heteroaryl, and heterocyclyl.