Patent ID: 7094799

Claim:
A solid composition comprising bicifadine hydrochloride polymorph form B substantially free of bicifadine hydrochloride polymorph form A, said solid composition comprising solid crystals of form B having a distinct infrared profile characterized by one or more of the following infrared spectrum peaks in wavenumbers (cm− 1 ): 3185 1111 2769 1022 2437 963 2276 904 2108 891 1908 856 1804 818 1658 783 1596 719 1518 684 1453 660 1403 637 1343 580 1305 532 1274 475 1209 422 1131 and a distinct x-ray powder diffraction (XRPD) profile characterized by one or more of the following XRPD peaks expressed in terms of “d” spacings and relative intensities I (s =strong, m=medium, w=weak, v=very, d=diffuse) 2θ (deg) d (Å) I a 5.08 17.39 Vs 10.07 8.77 S 15.19 5.83 S 16.83 5.27 S 18.64 4.76 Md 18.76 4.73 Md 19.64 4.52 W 20.16 4.40 M 21.96 4.05 M 22.37 3.97 S 23.16 3.84 W 24.00 3.70 W 25.27 3.52 D 27.33 3.26 Md 27.74 3.21 M 29.00 3.08 M 30.43 2.93 Md 31.84 2.80 Wd 32.29 2.77 W 35.27 2.54 Wd 35.64 2.52 W. s = strong, m = medium, w = weak, v = very, d = diffuse