Patent ID: 7422758

Claim:
An oral therapeutic formulation in the form of a beadlet comprising: a) an extruded-spheronized inner core containing at least one modified release first medicament selected from one or more vitamins, trace elements or minerals or mixtures thereof; b) an outer layer containing film forming agent selected from hydroxy propyl cellulose, hydroxypropylmethylcellulose, gum arabic, polyvinyl pyrrolidone, polyvinyl pyrrolidone-vinylacetate copolymer, copolymerisate of dimethyl amino methacrylic acid/neutral methacrylic acid esters or a mixture thereof, and containing at least one immediate release second medicament selected from one or more vitamins, trace elements or minerals or mixtures thereof; wherein the immediate release second medicament is a different chemical entity to the modified release first medicament; c) a pharmaceutically acceptable controlled-release first coating layer between the inner core and the outer layer, which coating controls the release of the inner core modified release first medicament and which first coating layer is selected from shellac, cellulose acetate phthalate, hydroxy propyl methyl cellulose phthalate, ethyl cellulose and polymerisates of acrylic acid esters or methacrylic acid esters; and d) a second coating layer between the inner core and the first coating layer of a pharmaceutically acceptable controlled release coating selected from hydroxy propyl cellulose, hydroxy propyl methylcellulose, gum arabic, polyvinyl pyrrolidone, polyvinyl pyrrolidone-vinylacetate copolymer and copolymerisate of dimethyl amino methacrylic acid/neutral methacrylic acid esters, or a mixture thereof.