Patent ID: 8084597

Claim:
An isolated fusion polypeptide comprising an entropic bristle domain (EBD) as set forth in SEQ ID NO selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 11, SEQ ID NO: 40, SEQ ID NO: 43 and SEQ ID NO: 44, or a fragment thereof, or a sequence having at least 90% identity to SEQ ID NO: 1, SEQ ID NO: 11, SEQ ID NO: 40, SEQ ID NO: 43 or SEQ ID NO: 44, and at least one heterologous polypeptide sequence, wherein the fusion polypeptide comprising said EBD, or said fragment thereof, or said sequence having 90% identity to SEQ ID NO: 1, SEQ ID NO: 11, SEQ ID NO: 40, SEQ ID NO: 43 or SEQ ID NO: 44 has increased solubility relative to the heterologous polypeptide sequence, reduced aggregation relative to the heterologous polypeptide sequence and/or improved folding relative to the heterologous polypeptide sequence.