Patent ID: 7183304

Claim:
A compound of the formula wherein L is radical in which R 1 is hydrogen, optionally substituted alkyl, aryl, heteroaryl, aralkyl or cycloalkyl; R″ is hydrogen, optionally substituted alkyl, alkoxy or halogen; m is an integer from 1 to 2; Y is hydrogen; R 4 is hydrogen; or R 4 and Y taken together with the carbon atoms they are attached to form a bond provided that m is 1; R and R′ are independently hydrogen, halogen, optionally substituted alkyl, alkoxy, aralkyl or heteroaralkyl; or R and R′ combined together form a methylenedioxy group provided that R and R′ are attached to carbon atoms adjacent to each other; or R and R′ combined together with the carbon atoms they are attached to form an optionally substituted 5- to 6-membered aromatic or heteroaromatic ring provided that R and R′ are attached to carbon atoms adjacent to each other; or R—C and R′—C may independently be replaced by nitrogen; X is —Z—(CH 2 ) p —Q—W wherein Z is a bond, O, S, —C(O)— or —C(O)NR 5 — in which R 5 is hydrogen, alkyl or aralkyl; p is an integer from 1 to 8; Q is a bond provided that Z is not a bond when p is 1; or Q is —O(CH 2 ) r — or —S(CH 2 ) r —, in which r is zero or an integer from 1 to 8; or Q is —O(CH 2 ) 1-8 O—, —S(CH 2 ) 1-8 O—, —S(CH 2 ) 1-8 S—, —C(O)— or —C(O)NR 6 — in which R 6 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl; W is cycloalkyl, aryl, heterocyclyl, aralkyl or heteroaralkyl; or W and R 6 taken together with the nitrogen atom to which they are attached form a 8- to 12-membered bicyclic ring, which may be optionally substituted or may contain another heteroatom selected from oxygen, nitrogen and sulfur; or a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers thereof.