Patent ID: 7632811

Claim:
A peptide of the formula (V): wherein A 1 is Ala, Ser, or Dap; A 3 is Ser or Aib; A 5 is His, Ile, or Cha; A 7 is Leu, Cha, Nle, β-Nal, Trp, Pal, Phe, or p-X-Phe in which X is OH, a halogen, or CH 3 ; A 8 is Leu, Met, or Cha; A 10 is Asp or Asn; A 11 is Lys, Leu, Cha, Phe, or β-Nal; A 12 is Gly or Aib; A 14 is Ser or His; A 15 is Ile, or Cha; A 16 is Gln or Aib; A 17 is Asp or Aib; A 18 is Leu, Aib, or Cha; A 19 is Arg or Aib; A 22 is Phe, Glu, Aib, Acc, or Cha; A 23 is Phe, Leu, Lys, Acc, or Cha; A 24 is Leu, Lys, Acc, or Cha; A 25 is His, Aib, or Glu; A 26 is His, Aib, or Lys; A 27 is Leu, Lys, Acc, or Cha; A 28 is Ile, Leu, Lys, Acc, or Cha; A 29 is Ala, Glu, or Aib; A 30 is Glu, Cha, Aib, Acc, or Lys; A 31 is Ile, Leu, Cha, Lys, Acc, or deleted; A 32 is His or deleted; A 33 is Thr or deleted; A 34 is Ala or deleted; each of R 1 and R 2 is, independently, H, C 1-12 alkanyl, C 7-20 phenylalkyl, C 11-20 naphthylalkyl, C 1-12 hydroxyalkyl, C 2-12 hydroxyalkenyl, C 7-20 hydroxyphenylalkyl, or C 11-20 hydroxynaphthylalkyl; or one and only one of R 1 and R 2 is COE 1 in which E 1 is C 1-12 alkyl, C 2-12 alkenyl, C 7-20 phenylalkyl, C 11-20 naphthylalkyl, C 1-12 hydroxyalkyl, C 2-12 hydroxyalkenyl, C 7-20 hydroxyphenylalkyl, or C 11-20 hydroxynaphthylalkyl; and R 3 is OH, NH 2 , C 1-12 alkoxy, or NH—Y—CH 2 -Z in which Y is a C 1-12 hydrocarbon moiety and Z is H, OH, CO 2 H or CONH 2 ; provided that at least one of A 23 , A 24 , A 27 , A 28 , or A 31 is Lys; or a pharmaceutically acceptable salt thereof.