Patent ID: 8304419

Claim:
A compound of formula (I): wherein m is 1, 2, 3 or 4; n is 2; each R 1 independently is halogen, —CN, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, hydroxyl, C 1 -C 8 alkoxy, —C(O)OR 5 , —C(O)N(R 5 ) 2 , —OR 5 , —R 3 CN, or —N(R 5 ) 2 ; each R 2 independently is halogen; A is C 5 -C 12 aryl or C 5 -C 12 heterocycle; Q is hydrogen or C 1 -C 4 alkyl; Y is —C(O)—, —S(O) 2 —, or —S(O)—; Z is C 4 -C 12 aryl, C 3 -C 14 heterocycle, R 3 Het, or R 3 Ar, each optionally substituted with one or more of C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 8 alkoxy, halogen, oxo, hydroxyl, —CN, —NO 2 , —N(R 5 )C(O)R 5 , —N(R 5 ) 2 , —OR 5 , —C 3 -C 12 Het, —C(O)N(R 5 ) 2 , C 4 -C 12 Ar, —SR 5 , —S(O) 2 N(R 5 ) 2 , —OR 3 HetC(O)R 5 , —OCF 3 , —S(O) 2 R 5 , —OR 3 R 5 , —N(R 5 )C(O)R 3 OR 5 ; —N(R 5 )C(O)R 3 N(R 5 ) 2 , —N(R 5 )C(O)R 3 R 5 , —OR 3 N(R 5 ) 2 , —R 3 Het, —R 3 N(R 5 ) 2 , —R 3 N(R 5 )C(O)R 5 , —OR 3 SR 5 , —C(O)R 5 , —C(R 5 ) 3 , —R 3 C(O)OR 5 , —R 3 C(O)N(R 5 ) 2 , or —N(R 5 )S(O) 2 R 5 ; or Z is linked to Q to form a C 4 -C 14 heterocycle together with the nitrogen atom and Y group to which they are attached and are optionally substituted with —C(O)OR 5 or C 1 -C 6 alkoxy; each R 5 independently is hydrogen, C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, oxo, C 3 -C 12 heterocycle, C 4 -C 12 aryl or C 1 -C 8 alkoxy, each optionally substituted with hydroxyl, C 1 -C 4 alkoxy or C 3 -C 7 cycloalkyl; R 3 is C 2 -C 6 alkenylene or C 1 -C 4 alkylene, each optionally substituted with hydroxyl or C 1 -C 8 alkoxy; Het is C 3 -C 12 heterocycle and is optionally substituted with one or more of C 1 -C 6 alkyl, —C(O)N(R 5 ) 2 , —R 3 S(O) 2 R 5 , or halogen; and Ar is C 4 -C 12 aryl and is optionally substituted with one or more of C 1 -C 6 alkyl or halogen; or a pharmaceutically acceptable salt thereof.