Patent ID: 7517900

Claim:
A compound of formula I: including all pharmaceutically acceptable salts and stereoisomers, wherein: R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; R 2 is selected from the group consisting of 3-halo, 3-aryl, 3-heteroaryl, 3-alkyl, 3-CN, 4-halo, 4-aryl, 4-heteroaryl, 4-alkyl, and -4-CN; R 3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; with the provisos that when R 4 is methyl or ethyl, R 3 is not ethyl; R 4 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 3 and R 4 can be taken together to form cycloalkyl or heterocyclyl; R 5 selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; A, B and E are independently selected from the group consisting of C and N, wherein at least one of A, B and E must be C; X is selected from the group consisting of CO, SO 2 and (CH 2 ) n ; Y is selected from the group consisting of a direct bond, SO 2 , CO, C═NH, C═N—CN and C═NR 5 ; Z is selected from the group consisting of a direct bond, NR 6 and O, with the proviso that when Y is a direct bond, Z is also a direct bond; R 6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; and n is an integer of 0 or 1.