Patent ID: 8153644

Claim:
A compound of formula (I): wherein: R 1 is phenyl or 5- or 6-membered heteroaryl, said phenyl and heteroaryl being unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—CF 3 ; R 2 is halogen, lower alkyl, haloloweralkyl or alkoxy; R 3 is nitrogen, oxygen or absent, said nitrogen being unsubstituted or substituted with lower alkyl; R 4 is carbon, NH, oxygen or absent, said carbon being unsubstituted or substituted with lower alkyl, wherein both R3 and R4 are not absent; R 5 is -lower alkyl, -alkoxy, -hydroxy, -amine, -lower alkyl amine, -haloloweralkyl, -lower alkoxy, -lower alkenyloxy, -cycloloweralkyl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl, -5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents from lower alkyl, hydroxy, halogen, —SO 2 -loweralkyl, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl, -6-membered aryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, —C(O)O-lower alkyl or —C(O)O-lower alkyl-phenyl, -5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —C(O)OH, C(O)O-lower alkyl or —C(O)O -lower alkyl-phenyl, —(CH 2 ) n C(O)OH, —CH 2 C(lower alkyl) 2 C(O)OH, —CH 2 (cycloalkyl)C(O)OH, -(cycloalkyl)C(O)OH, —CH 2 C(CH 3 ) 3 , —(CH 2 ) n -cycloalkyl, -cycloalkenyl, -bicycloalkenyl-C(O)OH, —(CH 2 ) n —O-alkyl, —O—C(═C)-lower alkyl, —O—(CH 2 ) n -phenyl, —NSO 2 -loweralkyl, —NSO 2 -cycloalkyl, —NSO 2 -aryl, —N-lower alkyl, —N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with —C(O)OH, —N-heterocycloalkyl, —N-aryl, —N—(CH 2 ) n -aryl, —N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl, —N—CH(lower alkyl)C(O)OH, —N-(cycloalkyl)C(O)OH, —N—CH(lower alkyl)C(O)O-lower alkyl, or -phenyl-C(O)OH, X is 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano; Y is phenyl, heteroaryl, cycloloweralkyl, 5- or 6-membered heterocycloalkyl, or —N(CH 2 ) n )N—, said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano; and n is 1, 2 or 3, or pharmaceutically acceptable salts thereof.