Patent ID: 6900316

Claim:
A process for preparing a 2-(pyridin-4-ylamino)-pyrido[2,3-d]pyrimidine of Formula II comprising reacting a 4-aminopyridine of the formula with an alkali metal amide or hydride and a 2-alkylsulfanyl-pyrido[2,3-d]pyrimidine of Formula I wherein: R′ and R″ independently are hydrogen, C 1 -C 6 alkyl, halogen, or phenyl; R 2 is hydrogen, (CH 2 ) n Ph, where Ph is phenyl or substituted phenyl, and n is 0, 1, 2, or 3, heteroaromatic, cycloalkyl, C 1 -C 6 alkyl, and C 2 -C 6 alkenyl, where the alkyl and alkenyl groups may be substituted by NR 5 R 6 , phenyl, substituted phenyl, alkoxy, halogen, cycloalkyl; R 5 and R 6 are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, (CH 2 ) n Ph where Ph is phenyl or substituted phenyl, and n is 0, 1, 2, or 3, cycloalkyl, heteroaromatic, R 5 and R 6 taken together with the nitrogen to which they are attached can complete a ring having 3 to 7 carbon atoms and optionally containing 1, 2, or 3 heteroatoms selected from nitrogen, substituted nitrogen, oxygen, and sulfur; and Ar is phenyl, substituted phenyl, or heteroaromatic.