Patent ID: 8269035

Claim:
A process for producing a radioactive fluorine-labeled organic compound, which comprises subjecting a compound represented by the following formula (1): wherein R 1 is a straight or branched alkyl chain with 1-10 carbon atoms or an aromatic substituent, R 2 is a straight or branched haloalkylsulfonic acid substituent with 1-10 carbon atoms, a straight or branched alkylsulfonic acid substituent with 1-10 carbon atoms, a fluorosulfonic acid substituent or an aromatic sulfonic acid substituent, and R 3 is a protective group to a heating step in an inert organic solvent in a presence of a phase transfer catalyst, 18 F ions and potassium ions, so as to obtain a compound represented by the following formula (2): wherein R 1 is a straight or branched alkyl chain with 1-10 carbon atoms or an aromatic substituent, R 3 is a protective group, in which the heating step is conducted at a heating temperature of 40-90° C., and the phase transfer catalyst is contained in the inert organic solvent at a concentration of not less than 70 mmol/L, potassium ions are contained in the inert organic solvent at a concentration of not less than 27 mmol/L, and the phase transfer catalyst is used in a molar ratio of not less than 0.7 relative to the compound represented by the formula (1).