Patent ID: 7179911

Claim:
A process for making a compound of formula II: comprising reacting a silyl ester of (3S)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxylic acid with a compound of formula III: wherein: J is selected from the group consisting of chlorine, bromine, fluorine, 1,2,4-triazolyl, benzotriazolyl and imidazolyl; R 1 and R 2 are each independently selected from the group consisting of H, C 1-6 alkyl, and —CCH; R 3 and R 4 are each independently selected from the group consisting of H and C 1-6 alkyl; R 5 is selected from the group consisting of H, —C(O)—C 1-6 alkyl, —C(O)—C 3-6 cycloalkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)O—C 1-6 alkyl, —C(O)O-aryl, and SiR 6 R 7 R 8 ; and R 6 , R 7 and R 8 are each independently selected from the group consisting of C 1-6 alkyl and phenyl; and hydrolyzing the silyl ester to provide the compound of Formula II.