Patent ID: 7173058

Claim:
A compound having the formula (I): wherein: Y is â€”C(O)â€”, â€”CH 2 , â€”CH 2 C(O)â€”, â€”C(O)CH 2 â€”, or SO 2 ; Z is â€”H, â€”C(O)R 3 , â€”(C 0-1 -alkyl)-SO 2 â€”(C 1-4 -alkyl), â€”C 1-8 -alkyl, â€”CH 2 OH, CH 2 (O)(C 1-8 -alkyl) or â€”CN; R 1 and R 2 are each independently â€”CHF 2 , â€”C 1-8 -alkyl, â€”C 3-18 -cycloalkyl, or â€”(C 1-10 -alkyl)(C 3-18 -cycloalkyl), and at least one of R 1 and R 2 is CHF 2 ; R 3 is â€”NR 4 R 5 , -alkyl, â€”OH, â€”O-alkyl, phenyl, benzyl, substituted phenyl, or substituted benzyl; R 4 and R 5 are each independently â€”H, â€”C 1-8 -alkyl, â€”OH, â€”OC(O)R 6 ; R 6 is â€”C 1-8 -alkyl, -amino(C 1-8 -alkyl), -phenyl, -benzyl, or -aryl; X 1 , X 2 , X 3 , and X 4 are each independent â€”H, -halogen, -nitro, â€”NH 2 , â€”CF 3 , â€”C 1-6 -alkyl, â€”(C 0-4 -alkyl)-(C 3-6 -cycloalkyl), (C 0-4 -alkyl)-NR 7 R 8 , (C 0-4 -alkyl)-N(H)C(O) â€”(R 8 ), (C 0-4 -alkyl)-N(H)C(O)N(R 7 R 8 ), (C 0-4 -alkyl)-N(H)C(O)O(R 7 R 8 ), (C 0-4 -alkyl)-OR 8 , (C 0-4 -alkyl)-imidazolyl, (C 0-4 -alkyl)-pyrrolyl, (C 0-4 -alkyl)-oxadiazolyl, or (C 0-4 -alkyl)-triazolyl or X1 and X2 or X2 and X3 or X3 and X4 are taken together with the atoms that join them to form a cycloalkyl or heterocycloalkyl ring of 3, 4, 5,6 or 7 atoms; and R 7 and R 8 are each independently H, C 1-9 -alkyl, C 3-6 -cycloalkyl, (C 1-6 -alkyl)-(C 3-6 -cycloalkyl), (C 1-6 -alkyl)-N(R 7 R 8 ), (C 1-6 -alkyl)-OR 8 , phenyl, benzyl, or aryl; or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof.