Patent ID: 6852714

Claim:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk 1 is C 1-4 alkylcarbonyl, C 1-4 alkylcarbonylC 1-4 alkyl, carbonyl, carbonylC 1-4 alkyl, or C 1-6 alkanediyl optionally substituted with hydroxy, C 4 alkyloxy, C 1-4 alkylcarbonyloxy, C 1-4 alkylcarbonyloxyC 1-4 alkyloxycarbonyloxy, or C 3-6 cycloalkylcarbonyloxyC 1-4 alkyloxycarbonyloxy; -Z 1 -Z 2 - is a bivalent radical of formula —CH 2 — (e-1), —CH═ (e-6), —O—CH 2 — (e-2), —CH 2 —CH═ (e-7), —S—CH 2 — (e-3), —CH 2 —CH 2 —CH═ (e-8), —CH 2 —CH 2 — (e-4), —CH═CH— (e-9); —CH 2 —CH 2 —CH 2 — (e-5), R 1 , R 2 and R 3 are each independently selected from hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 1-6 alkyloxy, trihalomethyl, trihalomethoxy, halo, hydroxy, cyano, nitro, amino, C 1-6 alkylcarbonylamino, C 1-6 alkyloxycarbonyl, C 1-4 alkylcarbonyloxy, aminocarbonyl, mono- or di(C 1-6 alkyl)aminocarbonyl, aminoC 1-6 alkyl, mono- or di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-4 alkylcarbonyloxy-C 1-4 alkyloxycarbonyloxy, or C 3-6 cycloalkylcarbonyloxyC 1-4 alkyloxy-carbonyloxy; or when R 1 and R 2 are on adjacent carbon atoms, R 1 and R 2 taken together may form a bivalent radical of formula (a-1) (a-6) —CH 2 —CH 2 —CH 2 —, —O—CH 2 —CH 2 —, (a-2) (a-7) —CH 2 —CH 2 —CH 2 —CH 2 —, —O—CH 2 —CH 2 —O—, (a-3) (a-8) —CH 2 —CH 2 —CH 2 —CH 2 —CH 2 —, —O—CH 2 —CH 2 —CH 2 —, (a-4) (a-9) —CH═CH—CH═CH—, —O—CH 2 —CH 2 —CH 2 —CH 2 —, (a-5) —O—CH 2 —O—, wherein optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by hydroxy, C 1-4 alkyl or CH 2 OH; R 4 is hydrogen, C 1-6 alkyl, or a direct bond when the bivalent radical -Z 1 -Z 2 - is of formula (e-6), (e-7) or (e-8); A is a bivalent radical of formula wherein the nitrogen atom is connected to Alk 1 and, m is 0 or 1; Alk 2 is C 1-6 alkanediyl; R 6 is hydrogen, C 1-6 alkyl, C 1-4 alkylcarbonyl, C 1-4 alkyloxycarbonyl, phenylmethyl, C 1-4 alkylaminocarbonyl, C 1-4 alkylcarbonyloxy-C 1-4 alkyloxycarbonyl, or C 3-6 cycloalkylcarbonyloxyC 1-4 alkyloxycarbonyloxy R 5 is a radical of formula wherein n is 1 or 2; p 1 is 0, and p 2 is [1 or ] 2; or p 1 is [1 or ] 2, and p 2 is 0; X is oxygen, sulfur, NR 9 or CHNO 2 ; Y is oxygen or sulfur; R 7 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, phenyl or phenylmethyl; R 8 is C 1-6 alkyl, C 3-6 cycloalkyl, phenyl or phenylmethyl; R 9 is cyano, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxycarbonyl or aminocarbonyl; R 10 is hydrogen or C 1-6 alkyl; and Q is a bivalent radical of formula —CH 2 —CH 2 — (d-1), —CH═CH— (d-4), —CH 2 —CH 2 —CH 2 — (d-2), —CH 2 —CO— (d-5), —CH 2 —CH 2 —CH 2 —CH 2 — (d-3), —CO—CH 2 — (d-6), wherein optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C 1-4 alkyl, hydroxy or phenyl, provided that when R 5 is (c-1), (c-2), (c-3) or (c-4), Q is (d-3) and provided that when R 5 is (c-5), Q is (d-1), (d-4), (d-5) or (d-6).