Patent ID: 7235560

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof in which: X is selected from the group consisting of oxygen or NR 2 ; R 1 is selected from the group consisting of H, C 1-6 alkyl, C 1-2 alkyl substituted by one to five fluorine atoms, C 3-6 alkenyl, C 3-6 alkynyl, C 3-10 cycloalkylC 0-6 alkyl, C 4-12 bridged cycloalkyl, A(CR 5 R 6 ) n and B(CR 5 R 6 ) n ; R 2 is selected from the group consisting of H and C 1-6 alkyl; R 3 is C 1-2 alkyl substituted by one to five fluorine atoms; R 4 is selected from the group consisting of C 1-6 alkyl, NH 2 and R 8 CONH; R 5 and R 6 are independently selected from H or C 1-6 alkyl; A is an unsubstituted 5- or 6-membered heteroaryl or an unsubstituted 6-membered aryl, or a 5- or 6-membered heteroaryl or a 6-membered aryl substituted by one or more R 7 ; R 7 is selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkyl substituted by one more fluorine atoms, C 1-6 alkoxy, C 1-6 alkoxy substituted by one or more F, NH 2 SO 2 and C 1-6 alkylSO 2 ; B is selected from the group consisting of defines the point of attachment of the ring; R 8 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylOC 1-6 alkyl, phenyl, HO 2 CC 1-6 alkyl, C 1-6 alkylOCOC 1-6 alkyl, C 1-6 alkylOCO, H 2 NC 1-6 alkyl, C 1-6 alkylOCONHC 1-6 alkyl and C 1-6 alkylCONHC 1-6 alkyl; and n is 0 to 4. wherein the 5-membered heteroaryl is selected from and wherein the 6-membered heteroarly is selected from