Patent ID: 7928121

Claim:
A method for treating a 5-HT 7 mediated disease or condition comprising administering a medicament comprising a compound of the formula I: wherein W is a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR 8 , —C(O)OR 8 , —C(O)NR 8 R 9 , —HC═NR 8 , —CN, —OR 8 , —OC(O)R 8 , —S(O) t —R 8 , —NR 8 R 9 , —NR 8 C(O)R 9 , —NO 2 , —N═CR 8 R 9 or halogen; wherein t is 1, 2 or 3; R 8 and R 9 are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, halogen; and the 1,2,3,4-tetrahydroisoquinoline group is linked through the methylene group to positions 3 or 4 of the piperidine ring; or a pharmaceutically acceptable salt or isomer thereof and a pharmaceutically acceptable carrier; wherein the 5-HT 7 mediated disease is sleep disorder, shift worker syndrome, jet lag, depression, seasonal affective disorder, migraine, anxiety, psychosis, schizophrenia, pain, cognition and memory disorders, neuronal degeneration resulting from ischemic events, cardiovascular diseases, hypertension, irritable bowel syndrome, inflammatory bowel disease, spastic colon or urinary incontinence.