Patent ID: 8217071

Claim:
A method of treating cancer, wherein the cancer is one that can be treated by inhibiting the degradation of p27, wherein said method comprises administering to a subject suffering from said cancer an effective amount of a compound of formula I: wherein R 1 and R 2 independently are hydrogen, C 1 -C 4 alkyl which is unsubstituted or substituted by OH, or C 1 -C 4 alkoxy; R 3 is hydrogen, C 1 -C 8 alkyl which is unsubstituted or substituted by OH or OR, wherein R is selected from hydrogen, C 1 -C 4 alkyl, aryl or acetyl, R 4 is hydrogen, halogen, C 1 -C 4 alkyl which is unsubstituted or substituted by OH, or C 1 -C 4 alkoxy; R 5 is hydrogen or halogen; R 6 is hydrogen or C 1 -C 4 alkyl; and X is C═CH 2 or CHR 7 wherein R 7 is C 1 -C 4 alkyl which is unsubstituted or substituted by —S—C 1 -C 4 alkyl, and pharmaceutically acceptable salts thereof, and wherein the administration of said compound results in stabilization and/or inhibition of the degradation of p27, thereby treating the cancer.