Patent ID: 8431705

Claim:
A one-pot process for the preparation of a compound comprising Formula (IV), the process comprising: (a) contacting a compound comprising Formula (I) with POCl 3 to form a compound comprising Formula (II); (b) contacting the compound comprising Formula (II) with an asymmetric catalyst and a hydrogen donor comprising a formate ion to form a compound comprising Formula (III); and (c) contacting the compound comprising Formula (III) with an alkali metal and an electron source to form the compound comprising Formula (IV) according to the following reaction scheme: wherein: R 1 , R 5 , and R 7 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, and —OR 111 ; R 2 , R 4 , and R 6 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, and —OR 211 ; R 3 is chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, and —OR 211 ; R 12 and R 13 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, and —OR 111 ; R 111 is chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 211 is chosen from hydrogen, hydrocarbyl, —C(O)R 212 , —C(O)C(R 212 ) 3 , —C(O)NHR 212 , and —SO 2 R 212 ; and R 212 is chosen from hydrocarbyl and substituted hydrocarbyl, and further wherein (i) the compound comprising Formula (II) is not isolated as a solid prior to step (b) and (ii) the compound comprising Formula (III) is not isolated as a solid prior to step (c).