Patent ID: 7390826

Claim:
A method of controlling progression of a cancer through metastasis in a male or female animal suffering from a colon cancer, lung cancer, or breast cancer comprising administering a therapeutically effective amount of (a) a compound having a formula wherein R 1 is selected from the group consisting of C(═O)C 3-8 cycloalkenyl, C(═O)C≡C—R b and R 2 is selected from the group consisting of C 1-3 alkyl and C 1-3 alkylenearyl; R 3 is selected from the group consisting of hydrogen and C 1-3 alkyl; R a is selected from the group consisting of hydrogen and C 1-3 alkyl; R b is selected from the group consisting of hydrogen and C 1-3 alkyl; R c is selected from the group consisting of hydrogen and C 1-3 alkyl; or a pharmaceutically acceptable salt thereof, and (b) a second therapeutically active ingredient used in a treatment of the cancer, wherein the second therapeutically active ingredient is a chemotherapeutic agent or radiation.