Patent ID: 7892779

Claim:
A method of detecting a chymase-associated disease in a human subject, comprising the steps of: a. obtaining a biological sample from the human subject; b. measuring the level of human Secretory Leukocyte Protease Inhibitor (SLPI) cleavage by human chymase in the biological sample, wherein the level of human SLPI cleavage by human chymase is measured as a ratio of a human SLPI fragment resulting from chymase cleavage to the full length SLPI present in the biological sample; and c. comparing the level measured from step b) to a control of the level of human SLPI cleavage by human chymase in a healthy human subject, wherein an elevated level of human SLPI cleavage by human chymase compared to said control indicates that the human subject has a chymase-associated disease or has increased risk of a chymase-associated disease.