Patent ID: 7176197

Claim:
A process for the synthesis of ivabradine, 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]-propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, of formula (I): and addition salts thereof with a pharmaceutically acceptable acid, wherein a compound of formula (V): wherein R 1 and R 2 , form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring, is subjected to a catalytic hydrogenation reaction, and the compound of formula (VI) thus obtained: is subjected to a reaction with a compound of formula (VII): wherein HX represents a pharmaceutically acceptable acid, in the presence of hydrogen and a catalyst, to yield directly, after filtering off the catalyst and isolation, the addition salt of ivabradine with the acid HX, which is optionally subjected, when it desired to obtain free ivabradine, to the action of a base.