Patent ID: 8188055

Claim:
A compound of formula (I): wherein X 1 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkylaminoalkyl, C 1 -C 6 dialkylaminoalkyl, C 1 -C 6 cyanoalkyl, C 1 -C 6 carbamoylalkyl, C 1 -C 6 pivaloylalkyl, C 1 -C 6 alkylcarbonyloxy C 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonylalkyl, ribose, 2′-deoxyribose, the conjugate acid form of a C 1 -C 6 carboxyalkyl, and the carboxylate anion of a C 1 -C 6 carboxyalkyl as the sodium salt; X 2 is selected from the group consisting of hydrogen, halo, hydroxy, a C 1 -C 6 alkyl, aryl, a C 1 -C 6 alkyl substituted aryl, nitro, a polycyclic aromatic C 1 -C 6 alkyl containing 2-4 aromatic rings, a C 3 -C 8 cycloalkyl, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl, a C 1 -C 6 hydroxyalkyl, a C 1 -C 8 alkoxy, a C 2 -C 8 alkoxyalkyl, aryloxy, acyloxy, an acyloxy-C 1 -C 6 alkyl, amino, a C 1 -C 6 alkylamino, a C 1 -C 6 dialkylamino, acylamino, ureido, thioureido, carboxy, a carboxy-C 1 -C 6 alkyl, cyano, a C 1 -C 6 cyanoalkyl, formyl, acyl, a di-C 1 -C 6 alkoxymethyl, an amino-C 1 -C 6 alkyl, and SO n R a , wherein n is 0, 1, 2, or 3 and R a is H, a C 1 -C 6 alkyl, or aryl; R 1 is selected from the group consisting of hydrogen, halo, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl, mercapto, C 1 -C 4 alkylthio, trifluoromethylthio, C 1 -C 4 thioacyl, hydroxy, C 1 -C 4 alkoxy, trifluoromethoxy, methanesulfonyloxy, trifluoromethanesulfonyloxy, C 1 -C 4 acyloxy, amino, C 1 -C 4 aminoalkyl, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino, trifluoromethylamino, ditrifluoromethylamino, aminomethanesulfonyl, C 1 -C 4 aminoacyl, aminotrifluoromethylcarbonyl, formylamino, nitro, nitroso, C 1 -C 4 alkyldiazo, C 5 -C 6 aryldiazo, trifluoromethyl, C 1 -C 4 haloalkyl, C 1 -C 4 cyanoalkyl, cyano, C 1 -C 4 alkyloxycarbonyl, C 1 -C 4 alkylcarbonyl, phenyl, phenylcarbonyl, formyl, C 1 -C 4 alkoxymethyl, phenoxymethyl, C 2 -C 4 vinyl, C 2 -C 4 ethynyl, and SO m R b , wherein m is 0, 1, 2, or 3 and R b is hydrogen, C 1 -C 4 alkyl, amino, or aryl; R 2 is selected from the group consisting of hydrogen, halo, hydroxy, a C 1 -C 6 alkyl, aryl, a C 1 -C 6 alkyl substituted aryl, nitro, a polycyclic aromatic C 1 -C 6 alkyl containing 2-4 aromatic rings, a C 3 -C 8 cycloalkyl, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl, a C 1 -C 6 hydroxyalkyl, a C 1 -C 8 alkoxy, a C 2 -C 8 alkoxyalkyl, aryloxy, acyloxy, an acyloxy-C 1 -C 6 alkyl, amino, a C 1 -C 6 alkylamino, a C 1 -C 6 dialkylamino, acylamino, ureido, thioureido, carboxy, a carboxy-C 1 -C 6 alkyl, cyano, a C 1 -C 6 cyanoalkyl, formyl, acyl, a di-C 1 -C 6 alkoxymethyl, a C 1 -C 6 aminoalkyl, and SO p R c , wherein p is 0, 1, 2, or 3 and R c is H, a C 1 -C 6 alkyl, or aryl; or a pharmaceutically acceptable salt thereof; provided that at least one of X 1 and X 2 is a folate residue and the other of X 1 and X 2 is a moiety other than a folate residue.