Patent ID: 8088820

Claim:
A method for treating or preventing malaria in a subject, comprising administering to said subject an effective amount of a substituted tetracycline compound of formula I or a pharmaceutically acceptable salt thereof: wherein: X is CR 6′ R 6 ; R 2 and R 2′ are each hydrogen; R 4′ and R 4″ are each alkyl; R 4 is NR 4′ R 4″ ; R 3 , R 11 and R 12 are each hydrogen; R 10 is hydrogen; R 5 is hydroxyl, hydrogen or thiol; R 6 and R 6′ are independently hydrogen, hydroxyl, thiol or alkyl; R 7 is substituted or unsubstituted furanyl, substituted or unsubstituted benzofuranyl, substituted or unsubstituted thienyl or substituted or unsubstituted benzothienyl; R 9 is hydrogen; and R 8 is hydrogen; such that malaria is treated or prevented in said subject.