Patent ID: 8546590

Claim:
A compound of Formula (VIII): wherein, z is 1, 2 or 3; T is >C═O or >S(═O) 2 ; Q is —OR 71 or —NR 72 R 73 ; U is —OR 74 or —NR 75 R 76 ; each R 68 and R 65 are the same or different and independently hydrogen, halogen, hydroxy, alkyl, aryl or —CH 2 As(═O)(OR 6 )(OR 7 ) or —CH 2 As(OR 6 ) 2 (OR 7 ) 2 ; each R 66 and R 67 are the same or different and independently hydrogen, halogen, hydroxy, alkyl or L-R x ; each R 70 is the same or different and independently hydrogen, halogen, alkyl, —As(═O)(OR 6 )(OR 7 ), —As(OR 6 ) 2 (OR 7 ) 2 or L-R x ; R 6 and R 7 are the same or different and independently H, alkyl, aryl, or heteroaryl; or R 6 and R 7 are linked together to form a 5 or 6-member heterocycle comprising the arsenic and the two oxygen atoms to which R 6 and R 7 are attached, wherein —R 6 -R 7 — is —[C(R 8 ) 2 ] w — (w is 2 or 3), wherein each R 8 is the same or different and independently hydrogen, hydroxy, cyano, —OC(O)-alkyl, —OC(O)-aryl, alkyl, aryl, alkylcarbonyl, arylcarbonyl, —CH 2 CN, —CH 2 SO 2 Me, —CH 2 SO 2 Ph, or two R 8 of adjacent carbons together with the carbons to which they are attached form an aryl or heteroaryl, or two R 8 of the same carbon form an oxo; each R 71 and R 74 are the same or different and independently is hydrogen, alkylcarbonyl or arylcarbonyl; each R 72 , R 73 , R 75 and R 76 are the same or different and independently hydrogen, alkyl or aryl; or R 71 and R 68 , together with the carbons to which they are attached, form a 5 or 6 member heterocycle; or R 74 and R 65 , together with the carbons to which they are attached, form a 5 or 6 member heterocycle; or R 72 and R 68 , together with the carbons to which they are attached, form a 5 or 6 member heterocycle; or R 73 and R 66 , together with the carbons to which they are attached, form a 5 or 6 member heterocycle; or R 75 and R 65 , together with the carbons to which they are attached, form a 5 or 6 member heterocycle; or R 76 and R 67 , together with the carbons to which they are attached, form a 5 or 6 member heterocycle; L is a single covalent bond or a covalent linkage having 1-30 non-hydrogen atoms selected from the group consisting of C, N, O and S and is composed of any combination of single, double, triple or aromatic carbon-carbon bonds, carbon-nitrogen bonds, nitrogen-nitrogen bonds, carbon-oxygen bonds and carbon-sulfur bonds; and R x is an acrylamide, an activated ester of a carboxylic acid, an acyl azide, an acyl nitrile, an aldehyde, an alkyl halide, an amine, an anhydride, an aniline, an aryl halide, an aziridine, a boronate, a carboxylic acid, a diazoalkane, a haloacetamide, a halotriazine, a hydrazine, a hydrazine, an imido ester, an isocyante, an isothiocyanate, a maleimide, a phosphoramidite, a sulfonyl halide, a thiol group, a succinimidyl ester, a pentafluorophenyl ester, or an azidoperfluorobenzamido group, provided, at least one of R 65 , R 66 R 67 , R 68 and R 71 is or comprises —As(═O)(OR 6 )(OR 7 ) or —As(OR 6 ) 2 (OR 7 ) 2 .