Patent ID: 7514417

Claim:
A method for treating a disease or condition that can be treated with a partial or full A 1 adenosine receptor agonist, the method comprising the administration to a mammal in need thereof of a therapeutically effective amount of a compound that is a partial or full A 1 adenosine receptor agonist, said compound having the structure of Formula I: wherein: R 1 is hydroxymethyl, —C(O)OR 6 , or —C(O)NHR 6 , in which R 6 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aryl, or optionally substituted heteroaryl; R 2 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R 3 , R 4 , and R 5 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, —CO 2 H, —SO 3 H, —C(O)OR 6 , —CH(OH)R 6 , or —C(O)NR 6 R 7 , wherein R 7 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aryl, or optionally substituted heteroaryl, or a salt, hydrate, or pharmaceutically acceptable ester thereof; wherein the disease or condition is chosen from atrial fibrillation, atrial flutter, congestive heart failure, epilepsy, stroke, diabetes, obesity, ischemia, stable angina, unstable angina, myocardial infarction, cardiac transplant, hyperlipidemia, hypertriglyceridemia, and metabolic syndrome.