Patent ID: 7098234

Claim:
A method for treating an allergic disease selected from the group consisting of allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy, comprising administering to a mammal an effective amount of an indole derivative represented by formula (I): wherein R represents hydroxy, C1–6 alkoxy, or NR 8 R 9 , in which R 8 and R 9 each independently represents a hydrogen atom, C1–6 alkyl, or SO 2 R 13 , in which R 13 represents C1–6 alkyl or a C3–15 saturated or unsaturated carbocyclic ring; R 2 represents a hydrogen atom, C1–6 alkyl, C1–6 alkoxy, C2–6 alkoxyalkyl, a halogen atom, amino, trihalomethyl, cyano, hydroxy, benzyl, or 4-methoxybenzyl; R 3 represents a hydrogen atom, C1–6 alkyl, C1–6 alkoxy, a halogen atom, trihalomethyl, cyano, or hydroxy; R 4 and R 5 each independently represents a hydrogen atom, C1–6 alkyl, C1–6 alkoxy, C2–6 alkoxyalkyl, a halogen atom, nitro, amino, trihalomethyl, cyano, or hydroxy; D represents a single bond, C1–6 alkylene, C2–6 alkenylene, or C1–6 oxyalkylene; in -G-R 6 , 1) G represents a single bond, C1–6 alkylene which may be substituted with 1 to 2 oxygen atom(s) and/or sulfur atom(s), C2–6 alkenylene which may be substituted with 1 to 2 oxygen atom(s) and/or sulfur atom(s), in which the alkylene and the alkenylene may be substituted with hydroxy or C1–4 alkoxy, —C(O)NH—, —NHC(O)—, —SO 2 NH—, —NHSO 2 —, or diazo; R 6 represents a C3–15 saturated or unsaturated carbocyclic ring, in which the ring may be substituted with 1 to 5 substituent(s) selected from C1–6 alkyl, C1–10 alkoxy, C2–6 alkoxyalkyl, a halogen atom, hydroxy, trihalomethyl, nitro, amino, phenyl, phenoxy, oxo, C2–6 acyl, C1–6 alkanesulfonyl and cyano, or 2) G and R 6 are taken together to represent (i) C1–15 alkyl which may be substituted with 1 to 5 oxygen atom(s) and/or sulfur atom(s); (ii) C2–15 alkenyl which may be substituted with 1 to 5 oxygen atom(s) and/or sulfur atom(s): or (iii) C2–15 alkynyl which may be substituted with 1 to 5 oxygen atom(s) and/or sulfur atom(s). in which the alkyl, the alkenyl and the alkynyl may he substituted with 1 to 12 substituent(s) selected from C1–6 alkoxy, a halogen atom, hydoxy, cyano, oxo and NR 11 R 12 , in which R 11 and R 12 each independently represents a hydrogen atom, C1–6 alkyl, C2–6 alkenyl, phenyl, benzoyl, naphthyl, phenyl substituted with C1–6 alkyl, or C1–6 alkyl substituted with phenyl or cyano; n represents 1 to 3; m represents 1 to 3; i represents 1 to 4; and represents double bond; or a non-toxic salt thereof.