Patent ID: 8258159

Claim:
A compound having the formula: wherein: R 0 is methylene; R 1 is NH(aralkyl), NHSO 2 aryl, NHSO 2 alkyl, CH 2 C(═O)alkoxy, NHC(═O)R 2 , or NHSO 2 R 2 ; R 2 is aryl, alkyl, alkoxy, aralkyl, aralkoxy, aralkylamino, arylamino, or alkylamino; Each R 3 is independently halo, nitro, aryl, amino, alkyl, alkoxy, NH-Boc, alkylsulfonyl, NHC(═O)alkyl, NHC(═O)aralkyl, or NHC(═O)arylamino; Each R 4 is independently amino, hydroxy, aralkoxy, NH(aryl), or NHC(═O)aryl; R 5 is H or alkyl; R 6 is H or ═O; A is SO 2 , PO 2 , or C═O; D is optional and may be one or more CH 2 groups; E is aryl or heteroaryl; n is 0, 1, or 2; m is 0 or 1; one of the three dashed-line portions may represent a double bond, and, q is 0, 1, 2, or 3; or a stereoisomer, partial stereoisomer, pharmaceutically acceptable salt, acid hydrate, or N-oxide thereof.