Patent ID: 7169781

Claim:
Compounds of formula (I): wherein: K and L are selected from the group consisting of hydrogen; halogen; alkyl; —OH; and —O-alkyl; X is selected from the group consisting of hydrogen; —OR 1 ; —SR 2 ; —S(O)R 2 ; —S(O) 2 R 2 ; —CH 2 —S—CH 2 —C(O) 2 —CH 2 —CH 3 ; —CH 2 —S—(CH 2 ) 2 —OH and a group A 1 -Q; wherein: A 1 is a C 1 –C 3 -alkylene group; and Q is selected from the group consisting of —OR 1 ; —SR 2 ; —S(O)R 2 ; —S(O) 2 R 2 ; —NR 3 R 4 ; —NH—(CH 2 ) 2 —NR 3 R 4 and halogen; R 1 is selected from the group consisting of hydrogen; alkyl; allyl; dimethylphosphonylmethyl; 2,3-epoxy-1-propyl; (R)-2,3-dihydroxy-1-propyl; (S)-2,3-dihydroxy-1-propyl; 1,3-dihydroxy-2-propyl; 3-hydroxy-2-hydroxymethyl-1-propyl; 2-methoxyethoxymethyl; 2,2-dimethyl-1,3-dioxolan-4-ylmethyl and a group A 1 -Q 1 ; Q 1 is selected from the group consisting of —O-alkyl; —CN; —C(O) 2 H; —C(O) 2 -alkyl; —C(O)—NR 3 R 4 ; —S-alkyl; —S(O)-alkyl and —S(O) 2 -alkyl; except that if A 1 represents 1,2-ethylen- or 1,3-propylene group then Q 1 is —OH or —NR 3 R 4 ; R 3 and R 4 are independently hydrogen or alkyl; or R 3 and R 4 together with the nitrogen atom to which they are attached form a 5 to 7 membered, saturated or unsaturated ring, which is unsubstituted or substituted by a methyl group and wherein one additional nitrogen- or oxygen atom is present, with the remaining atoms being carbon atoms; R 2 is selected from the group consisting of alkyl; dimethylphosphonylmethyl; 2,3-epoxy-1-propyl; 2,3-dihydroxy-1-propyl; 2,2-dimethyl-1,3-dioxolan-4-ylmethyl and A 1 -Q 1 ; Y is aryl or heteroaryl, which are both unsubstituted or substituted one, two or three times by halogen; —CH 2 OR 5 ; —R 5 ; —OR 5 ; —NR 6 R 7 ; —SR 5 ; —S(O)R 5 ; —S(O) 2 R 5 ; —S(O)NHR 5 ; —S(O) 2 NHR 5 ; —S(O)NR 6 R 7 ; —S(O) 2 NR 6 R 7 ; —C(O)NHR 5 ; —C(O)NR 6 R 7 ; or CN; wherein: R 5 is hydrogen or alkyl, which alkyl is unsubstituted or substituted with OH, —O-alkyl or —NR 6 R 7 , with the proviso that two heteroatoms are not connected to the same carbon atom; R 6 and R 7 are independently hydrogen or alkyl; or R 6 and R 7 together with the nitrogen atom to which they are attached form a 5 to 7 membered, saturated or unsaturated ring, which is unsubstituted or substituted by a methyl group and wherein one additional nitrogen- or oxygen atom is present, with the remaining atoms being carbon atoms; Z is selected from the group consisting of halogen; —OH; —O-allyl; alkyl; methoxymethoxy; (2-methoxyethoxy)methyloxy; methylthio; ethoxymethoxy; methylendioxy; ethynyl; trimethylsilylethynyl; —O-alkyl, wherein the alkyl group is unsubstituted or substituted with pyridinyl; and benzyloxy which is unsubstituted or substituted by halogen, methoxy, ethoxy, methylenedioxy, —CN, —NO 2 , or —C(O) 2 H; and n is 1 or 2; or pharmaceutically acceptable salts thereof.