Patent ID: 8501191

Claim:
An FGFR2 fusion protein comprising a polypeptide and a fusion partner, wherein the polypeptide consists of the extracellular domain of FGFR2-IIIb, which lacks, as compared to wild-type FGFR2-IIIb, a sequence of up to 22 residues counting from the wild-type extracellular domain C-terminus, wherein the polypeptide lacks at least the amino acid residues of SEQ ID NO: 253, wherein the extracellular domain optionally lacks the native leader sequence, wherein the wild-type extracellular domain C terminus is defined as ending with the amino acids of SEQ ID NO: 253, and wherein the fusion partner is chosen from an Fc polypeptide, a polyethylene glycol, albumin, a domain of a constant region of a heavy or light chain of a mammalian immunoglobulin, and a hinge and the CH2 and CH3 constant domains of a human IgG.