Patent ID: 6992089

Claim:
A compound of formula I: wherein: one of R 1 , R 2 , R 3 , and R 4 is nitro or NR a R b ; and the remaining R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, NR a R b , COOR c , OR d ; or R 1 and R 2 , R 2 and R 3 , or R 3 and R 4 taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy; R 5 is hydrogen, hydroxy, or fluoro; each R 6 , R 7 , and R 8 is independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, NR a R b , COOR c , OR d ; or R 6 and R 7 , or R 8 and R d taken together are methylenedioxy, 1,2-ethylenedioxy, or 1,3-propylenedioxy; R 9 is (C 1 -C 6 )alkyl substituted with one or more (C 1 -C 6 ) alkoxycarbonyl, cyano, halo, hydroxy, mercapto, oxo, carboxy, nitro, pyrrolidinyl, pineridinyl, imidazolidinyl, imidazolinyl, niperazinyl, morpholinyl, thiomorpholinyi, or —NR f R g groups, wherein R f and R g may be the same or different and are chosen from hydrogen, (C 1 -C 6 )alkyl, and (C 3 -C 6 )cycloalkyl; W is N or CH; X is two hydrogens, ═O, ═S, or ═NR e ; R a and R b are each independently hydrogen or (C 1 -C 6 )alkyl, or R a and R b together with the nitrogen to which they are attached form a pyrrolidino, piperidino or morpholino ring; each R c is hydrogen, (C 1 -C 6 )alkyl, aryl, or aryl(C 1 -C 6 )alkyl; each R d is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, aryl, or aryl(C 1 -C 6 )alkyl; and R e is hydrogen, (C 1 -C 6 )alkyl, aryl, or aryl(C 1 -C 6 )alkyl; or a pharmaceutically acceptable salt thereof.