Patent ID: 7335678

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein — is absent or is a single bond; X 1 is CR 1 ; X 2 is CR 2 ; X 3 is NR 3 ; X 4 is a bond; X 5 is N; Z 1 is O; Z 2 is NH; L is selected from the group consisting of alkenylene, alkylene, alkynylene, cycloalkylene, —(CH 2 ) m O(CH 2 ) n —, and N(R Y ), wherein the left end of —(CH 2 ) m O(CH 2 ) n — is attached to Z 2 and the right end is attached to R 9 ; m and n are each independently 1-6; R Y is selected from the group consisting of hydrogen and alkyl; R 1 , R 3 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, NR A S(O) 2 R B , —S(O) 2 R B , —NZ A Z B , (NZ A Z B )alkyl, (NZ A Z B )carbonylalkyl and (NZ A Z B )sulfonyl, wherein Z A and Z B are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, and arylalkyl; R 2 and R 4 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, —NR A S(O) 2 R B , —S(O) 2 OR A , —S(O) 2 R B , —NZ A Z B , (NZ A Z B )alkyl, (NZ A Z B )alkylcarbonyl, (NZ A Z B )carbonyl, (NZ A Z B )carbonylalkyl, and (NZ A Z B )sulfonyl; R A is selected from the group consisting of hydrogen and alkyl; R B is selected from the group consisting of alkyl, aryl, and arylalkyl; R 8a is selected from the group consisting of hydrogen and alkyl; and R 9 is selected from the group consisting of hydrogen, aryl, cycloalkyl, and heterocycle.