Patent ID: 7888107

Claim:
A system for processing a nucleic acid comprising: a disposable self-contained processing module, the disposable self-contained processing module further comprising a sample well, a valve plate, a manifold assembly and a substrate assembly stacked one on top of another with the substrate assembly occupying a bottom of the stack, the manifold assembly mounted on top of the substrate assembly, the sample well mounted on top of the manifold assembly with the valve plate slidably disposed between the manifold assembly and sample well and adapted to laterally slide as a single unit relative to the manifold assembly and sample well, the substrate assembly further comprising a substrate where the substrate and manifold assembly together define a hybridization chamber between the substrate and manifold assembly, the manifold assembly further comprises a plurality of channels between the hybridization chamber and an opposing side of the manifold assembly, the sample well further comprises a plurality of liquid wells each with a first aperture on an outside surface of the disposable self-contained processing module and a second aperture on a side of the sample well facing the slidable valve plate and where the slidable valve plate further comprises a plurality of sets of channels extending through the valve plate from the sample well side to the manifold assembly side, the slidable valve plate having a plurality of predetermined positions with respect to the sample well and manifold assembly, where each position of the plurality of positions forms a different set of fluid connections between respective one or more of the liquid wells of the sample well and the hybridization chamber through the valve plate and manifold assembly.