Patent ID: 8486929

Claim:
A method for treatment of a infection with Gram-negative bacteria in mammals in need of such treatment comprising administering to said mammals a combination of monobactam antibiotic containing an oxyimino moiety >C—N—O—, said antibiotic having the formula (I) wherein said oxyimino moiety has the Z-orientation, or a pharmaceutically acceptable salt thereof and at least one carbapenem antibiotic, selected from the group consisting of Meropenem, Imipenem, Ertapenem, Doripenem and pharmaceutically acceptable salts thereof; said combination being administered in a dose effective for treatment of said infection and said infection is selected from the group consisting of nosocomial pneumonia, community-acquired pneumonia, urinary tract infection, complicated intra-abdominal infection, complicated skin/skin structure infection, infectious exacerbations of cystic fibrosis, sepsis and melioidosis.