Patent ID: 6982083

Claim:
A pharmaceutical composition, comprising starch granules containing at least one fusion polypeptide comprising: In the N terminal position: the peptide sequence of SEQ ID No: 3 comprising the granule bound starch synthase GBSSI of Chlamydomonas reinhardtii or the sequence SEQ ID No: 5 comprising the GBSSI of Chlamydomonas reinhardtii in the form of mature protein of 651 amino acids, said sequences being encoded by nucleotide sequences SEQ ID No: 2, and 4 respectively, and, in the C-terminal position, a peptide or polypeptide of interest, the C-terminal part of the amino acid sequence of the GBSSI thus being bound to the N-terminal part of the peptide sequence of interest, the said fusion polypeptide being encoded by a recombinant nucleotide sequence containing in the 5′→3′ direction, a nucleotide sequence coding for said Chlamydomonas reinhardtii GBSSI, the said nucleotide sequence coding for this enzyme being positioned upstream of a nucleotide sequence coding for the peptide or polypeptide of interest, the peptide of interest in the said fusion polypeptides possessing a defined therapeutic effect.