Patent ID: 8426440

Claim:
A compound of formula (I) wherein R 1 is a radical —(CH 2 ) n —NR 3 R 4 , located on positions 6, 7 or 8, where n is 0, 1 or 2; and each of R 3 and R 4 , independently, is hydrogen; optionally-substituted C 1-6 -alkyl; C 3-6 -cycloalkyl; carboxy-C 1-6 -alkoxy; C 2-4 -alkenyl; or C 1-6 -alkyl-carbonyl; or R 3 and R 4 form together with the nitrogen atom to which they are bound, a heterocyclic residue; R 2 is hydrogen; halogen; CF 3 ; OH; CN; SH; NH 2 ; NO 2 ; —CHO; C(O)NH 2 ; optionally-substituted C 1-4 -alkyl; C 1-4 -alkylthio; C 1-4 -alkoxy; C 1-4 -alkyl-sulfoxide; C 1-4 -alkyl-sulfone; NHC 1-4 -alkyl; N(C 1-4 -alkyl) 2 ; C 2-4 -alkenyl; C 1-4 -alkyl-carbamoyl; or (C 1-4 -alkyl) 2 -carbamoyl; ring A contains one nitrogen atom; ring B may further be substituted by a halogen on position 4; R is a radical of formula (a), (b), (c) or (d), wherein R a is hydrogen; optionally-substituted C 1-6 -alkyl; C 4-8 -cycloalkyl or an optionally-substituted heterocyclic residue; each of R b , R c and R d , independently, is HYDROGEN; halogen; CF 3 ; CN; optionally-substituted C 1-6 -alkyl; C 1-15 -alkoxy optionally interrupted by one or two oxygen atom(s) and optionally-substituted; carbamoyl-C 1-6 -alkoxy; (C 1-4 -alkyl)carbamoyl-C 1-6 -alkoxy; (C 1-4 -alkyl) 2 -carbamoyl-C 1-6 -alkoxy; carboxy-C 1-6 -alkoxy; or C 1-6 -alkoxy-carbonyl; or is of the formula O—(CH 2 ) p —NR x R y , wherein; each of R X and R y , independently, is hydrogen or C 1-4 -alkyl; and p is 2, 3 or 4 or is of the formula —(CH 2 ) o —NR v R w wherein each of R v and R w , independently, is hydrogen; C 1-4 -alkyl-C 1-6 -alkoxy; C 1-4 -alkyl-NH—C 1-4 -alkyl; or C 1-4 -alkyl-N(C 1-4 -alkyl) 2 and o is 1, 2, 3 or 4; and R e is hydrogen; halogen; CF 3 ; CN; C 1-6 -alkyl; or C 1-6 -alkoxy; provided that i) when R is a radical of formula (a) and R 1 is on position 7, either ring A contains one nitrogen atom at position 5, position 6 or position 8, or two nitrogen atoms at positions 5 and 8; ii) when R is a radical of formula (b) or (c), then R 1 is on position 7; iii) when R is a radical of formula (d), then R 1 is on position 7 and ring A contains one nitrogen atom at position 5 or position 6; or a physiological hydrolysable derivative or a salt thereof.