Patent ID: 8920819

Claim:
A composition comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body, wherein the lipophilic derivative of the hydrophilic drug comprises a hydrophilic drug and a cleavable lipophilic linker; wherein the hydrophilic drug is a neuroactive peptide; wherein the lipophilic linker comprises a C 4-30 alkyl group, a C 4-30 acyl group, a C 4-30 alkenyl group, a C 4-30 alkynyl group, a C 5-20 aryl group, a multicyclic hydrophobic group with more than one C 4 -C 8 ring structure, a multicyclic hydrophobic group with more than one C 4 -C 8 heteroatom ring structure, a polyoxa C 1 -C 4 alkylene group, a poly (lactic acid) group, a poly(lactide-co-glycolide) group, or a poly(glycolic acid) group; wherein the amphiphile compound is an amphiphilic carbohydrate compound; and wherein the composition is formulated for administration by all routes except topical route.