Patent ID: 7973129

Claim:
A multilayer film, the film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes, wherein a first layer polyelectrolyte comprises a first layer polypeptide comprising one or more first amino acid sequence motifs, wherein the one or more first amino acid sequence motifs consists of 5 to 15 amino acids and has a net charge per residue of greater than 0.4, wherein the first layer polypeptide is at least 15 amino acids long, and has a balance of charge at pH 7 greater than or equal to approximately one-half of the total length of the first layer polypeptide; wherein the first layer polypeptide comprises a therapeutic agent reversibly covalently linked to the N-terminus or the C-terminus of the first layer polypeptide; and wherein a second layer comprises a second layer polyelectrolyte comprising a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule, wherein the second layer does not comprise a polypeptide.