Patent ID: 8703700

Claim:
A compound represented by the formula: wherein, Z is O, NH, or (CH 2 ) n , wherein when Z is (CH 2 ) n then up to three methylene units of Z are optionally and independently replaced by alkenylene, alkynylene, C 3 -C 7 cycloalkylene, C 4 -C 7 cycloalkenylene, heterocycloalkylene, —CO—, —C(S)—, —CONR—, —COO—, —COOR—, —NRCO—, —O—, —NRCONR—, —S—, —SO—, —SO 2 —, —NR—, —SO 2 NR—, or —NRSO 2 NR— and wherein up to 3 carbon atoms of Z are optionally and independently mono- or disubstituted by R1; X is —NHSO 2 X 1 — or wherein X 1 is NH, O, or (CH 2 ) m , wherein when X 1 is (CH 2 ) m then up to three methylene units of X 1 are optionally and independently replaced by alkenylene, alkynylene, C 3 -C 7 cycloalkylene, C 4 -C 7 cycloalkenylene, heterocycloalkylene, —CO—, —C(S)—, —CONR—, —COO—, —COOR—, —NRCO—, —O—, —NRCONR—, —S—, —SO—, —SO 2 —, —NR—, —SO 2 NR—, or —NRSO 2 NR—, and wherein up to 3 carbon atoms of X 1 are optionally and independently mono- or disubstituted by R1; A is optionally substituted C 4 -C 10 alkylene, wherein up to three methylene units of A are optionally and independently replaced by alkenylene, alkynylene, C 3 -C 7 cycloalkylene, C 4 -C 7 cycloalkenylene, heterocycloalkylene, heteroaryl, —CO—, —C(S)—, —CONR—, —COO—, —COOR—, —NRCO—, —O—, —NRCONR—, —S—, —SO—, —SO 2 —, —NR—, —SO 2 NR—, or —NRSO 2 NR—, wherein up to 3 carbon atoms of A are optionally and independently mono- or disubstituted by R1; Y is COOH, COOR, CONHR, —COCONHR, CONHSO 2 R, CONH(SO 2 )NRR, CONHP(O)(OR) 2 , or CONHP(O)(OR)(NRR); G1 and G2 independently are absent or are selected from the group consisting of monocyclic or bicyclic aryl or heteroaryl, optionally substituted by up to 3 R2 moieties, provided that at least one of G1 and G2 is present; R is H, C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl; R1 is hydrogen, optionally substituted C 1 -C 12 alkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclo, optionally substituted heteroaryl, amido, carboxyl, sulfonamido, halo, —OR, —CN, —NO 2 , —NRR, or —OCF 3 , R2 independently is selected from the group consisting of C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 3 -C 8 cycloalkyl, C 4 -C 8 cycloalkenyl, aryl, heteroaryl, and heterocyclo, each optionally substituted by up to three substitutents independently selected from the group consisting of optionally substituted C 1 -C 12 alkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 4 -C 8 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclo, halo, —OR, —CN, —NO 2 , —NRR, —OCF 3 , —COOR, CONRR, COR, SO 2 R, and SOR; m is 0-9 and n is 0-9.