Patent ID: 7341991

Claim:
A method of specifically inhibiting the β-secretase activity to cleave an amyloid precursor protein (APP), while maintaining its activities to substrates other than APP, said method comprising contacting the APP with a compound capable of binding to the β-secretase recognition or cleavage site on the APP, allowing the compound to bind to the β-secretase recognition or cleavage site on the APP and blocking the β-secretase recognition or cleavage site from binding by the β-secretase, thereby protecting the APP from cleavage by β-secretase, wherein the compound is selected from the group consisting of SEFCIHLHFR (SEQ ID NO:6), SEFCIQIHFR (SEQ ID NO:7), EFCIQIHFR (SEQ ID NO:15), FCIQIHFR (SEQ ID NO:16), CIQIHFR (SEQ ID NO:17), IQIHFR (SEQ ID NO:18), QIHFR (SEQ ID NO:19), SEFCIQIHF (SEQ ID NO:20), SEFCIQIH (SEQ ID NO:21), SEFCIQI (SEQ ID NO:22), SEFCIQ (SEQ ID NO:23), SEFCI (SEQ ID NO:24), SEFC (SEQ ID NO:25), FCIQIHF (SEQ ID NO:26), EFCIQIHF (SEQ ID NO:27), CIQI (SEQ ID NO:28), and CIQIHF (SEQ ID NO:29).