Patent ID: 6979436

Claim:
A metallopeptide comprising a manufactured peptide and pharmaceutically acceptable salts thereof comprising a metal ion-binding domain comprising two or more contiguous amino acids forming a nitrogen-containing and sulfur-containing ligand available for complexing with a metal ion and a determined biological function domain comprising a phenol moiety and a phenyl moiety and specific for one or more opioid receptors, wherein at least a portion of said biological function domain is co-extensive with at least a portion of the metal-ion binding domain, and wherein said biological-function domain is comformationally constrained upon complexing the metal-ion binding domain with a metal ion, and a metal ion complexed to the metal ion-binding domain, with the structure: wherein M is the metal ion; R 1 ′ is a phenol moiety side chain; R 2 ′ is H or a neutral or basic side chain; and R 4 is an L- or D-amino acid with a phenyl moiety-containing side chain and a terminal free carboxylate or amide.