Patent ID: 7169566

Claim:
An isolated antibody or fragment thereof selected from the group consisting of: (a) an isolated antibody that specifically binds to a protein selected from the group consisting of: (i) a protein whose amino acid sequence consists of amino acid residues 1 to 182 of SEQ ID NO:2; (ii) a protein whose amino acid sequence consists of amino acid residues 2 to 182 of SEQ ID NO:2; (iii) a protein whose amino acid sequence consists of amino acid residues 16 to 182 of SEQ ID NO:2; (iv) a protein whose amino acid sequence consists of amino acid residues 13 to 22 of SEQ ID NO:2; (v) a protein whose amino acid sequence consists of amino acid residues 31 to 46 of SEQ ID NO:2; (vi) a protein whose amino acid sequence consists of amino acid residues 55 to 103 of SEQ ID NO:2; (vii) a protein whose amino acid sequence consists of amino acid residues 123 to 151 of SEQ ID NO:2; (viii) a protein whose amino acid sequence consists of amino acid residues 159 to 173 of SEQ ID NO:2; (ix) a protein whose amino acid sequence consists of the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 209042; (x) a protein whose amino acid sequence consists of the amino acid sequence of the mature polypeptide encoded by the cDNA contained in ATCC Deposit No. 209042; and (xi) a protein whose amino acid sequence consists of a fragment of the polypeptide encoded by the cDNA contained in ATCC Deposit Number 209042, wherein said fragment is at least 30 contiguous amino acid residues in length; (b) an isolated antibody or fragment thereof that specifically binds a TACE-like protein wherein the antibody is produced by immunizing an animal with a protein selected from the group consisting of (a)(i)–(a)(xi); and (c) an isolated antibody or fragment thereof that specifically binds a TACE-like protein purified from a cell culture, wherein said TACE-like protein is encoded by a polynucleotide encoding amino acids 1 to 182 of SEQ ID NO:2.