Patent ID: 8623865

Claim:
A method of treatment of microbial infections which comprises administering to a patient in need thereof an efficient amount of a compound of formula (I): wherein: W, X and Y independently represent CH 2 or C=0, wherein said CH 2 group may be optionally independently substituted by a fluorine or (C 1 -C 6 ) alkyl group, wherein said (C 1 -C 6 ) alkyl group may be further substituted by one or two R5 groups; R1 represents H, (C 1 -C 6 ) alkyl optionally substituted by a CONR a R b group, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, phenyl or a —Z-Het group, such that Z represents a bond or a linker selected from CO, (C 1 -C 6 ) alkylene or —CO—(C 1 -C 6 ) alkylene and Het represents a 4-6 membered monocyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, wherein said phenyl or heterocycle group of R1 may be optionally substituted by one or more R5 groups; R2 represents H, C0 2 R a , COR a , CONR a R b , CH 2 OR c , CH 2 NR a R b , SO 2 NR a R b or P(O)OR a OR b ; R3 represents halogen, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl or (C 2 -C 6 ) alkynyl; R4 represents H, halogen, CN or CH 3 ; R a , R b and R c , independently represent H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, or an NR a R group may optionally form a 3- to 7-membered nitrogen containing saturated heterocycle optionally containing 1 to 3 additional heteroatoms selected from N, O or S wherein said heterocycle may be optionally substituted by one or more (C 1 -C 6 ) alkyl groups; R5 represents halogen, CN, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, CO 2 R a , COR a , CONR a R b OCOR a , OR a , NR a R b , ON═CR a R b , NR c COR a , NR c COOR a , OCONR a R b , NR c CONR a R b , NR c SO 2 R a , S(O) n R a , or SO 2 NR a R b ; n represents an integer selected from 0 to 2; or a pharmaceutically acceptable salt or solvate thereof.