Patent ID: 7612069

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R 1 is naphthyl optionally substituted with halogen, quinolyl, thienyl, 2,3-dimethyl-1H-indol-5-yl, or phenyl in which said phenyl is optionally substituted with one or more groups selected from halogen, CN, CF 3 , OH, —NH 2 , C 3-6 cycloalkyl, C 1-6 alkoxy, OR 21 , C 1-6 alkyl optionally substituted with OH or —NH 2 , —(CH 2 ) m —NHC(═O)OR 17 , —(CH 2 ) m —NHC(═O)Ophenyl optionally substituted with halogen, —(CH 2 ) m —NHC(═O)R 18 , —NH(C═O)R 19 , —CH 2 NH(SO 2 )R 20 , R 22 , R 23 , and —CH 2 morpholino; R 2 and R 3 are each independently hydrogen, methyl or hydroxymethyl; R 4 is hydrogen, C 1-6 alkyl optionally substituted with C 1-4 alkoxy or thiomethyl; or phenyl optionally substituted with one or more groups selected from halogen, C 1-4 alkyl, C 1-4 alkoxy, nitro and dimethylamino; R 5 is phenyl in which said phenyl is optionally substituted with one or more groups selected from halogen, —S(O) 2 methyl, C 1-4 alkyl and C 1-4 alkoxy; X is O, S, NH or NHCH 3 ; m is 0 or 1; R 17 is C 1-6 alkyl optionally substituted with C 1-4 alkoxy, halogen, C 2-3 alkynyl, 4-nitrophenyl, benzyloxy or benzothiophene 1,1-dioxide; R 18 is C 1-6 alkyl or C 3-6 cycloalkyl in which each is optionally substituted with a group selected from halogen, CN, CF 3 , —N(CH 3 ) 2 , C 1-4 alkoxy, C 3-6 cycloalkyl, morpholino, thienyl, imidazolyl, pyridyl, azepinyl, benzothienyl, benzofuranyl, phenyl and methoxyphenyl; R 19 is C 1-6 alkyl optionally substituted with methoxyethyloxy or methylthio; C 1-4 alkoxy optionally substituted with halogen; C 3-6 cycloalkyl, phenyl, pyridyl optionally substituted with one or two halogen and C 1-4 alkyl; benzothienyl, 1-methyl-2-pyrrolyl or furanyl; R 20 is C 1-6 alkyl, 1,2-dimethyl-1H-imidazolyl, thienyl or phenyl in which said phenyl is optionally substituted with a group selected from acetyl, C 1-4 alkoxy, benzyloxy, halogen, NH(C═O)CH 3 and nitro; R 21 is C 1-6 alkyl optionally substituted with a group selected from C 1-4 alkoxy, halogen, phenyl, furanyl and methylamino; R 22 is —CH═CH-phenyl or —CH═CH—C 1-4 alkyl optionally substituted with C 1-4 alkoxy or OH; and R 23 is pyridyl, thienyl, C 2-6 alkenyl, or phenyl optionally substituted with halogen; or a nontoxic pharmaceutically acceptable salt thereof.