Patent ID: 7741364

Claim:
A compound of the formula (I): or a pharmaceutically acceptable salt, ester, amide thereof, wherein: A is a 6-membered aryl ring; R 1 is —SO 2 R 10 ; R 2 is hydrogen or alkyl; R 3 is —C(O)R 12 ; R 4 is aryl substituted with 0, 1, 2, 3, 4, or 5 substituents independently elected from acyl, acyloxy, alkenyl, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amino, carboxy, cyano, cyanoalkyl, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, —NR A R B , (NR A R B ) alkyl, (NR A R B )alkoxy, (NR A R B )carbonyl, and (NR A R B )sulfonyl, wherein R A and R B are independently selected from hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, and formyl, or —R 14 R 15 ; R 5 is hydrogen, halo, aryl, heteroaryl, bicyclic heteroaryl, —R 23 —R 24 , or —R 23 —C(O)—R 24 ; R 10 is NR 11a R 11b ; R 11a and R 11b are independently hydrogen or alkyl; or R 11a and R 11b taken together with the nitrogen atom to which each is attached form a 4-, 5-, or 6-membered heterocycle; R 12 is hydrogen, alkyl, heterocycle, heteroarylalkyl, or —NR 16 R 17 , R 14 is aryl; R 15 is aryl, heteroaryl, heterocycle or R 16 and R 17 are independently hydrogen, alkyl, alkoxy, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclealkyl, hydroxyalkyl or R 18 R 19 N-alkyl-; R 18 and R 19 are independently hydrogen or alkyl; R 21 is aryl or heteroaryl; R 22 is arylalkyl; R 23 is aryl; and R 24 is heteroaryl or heterocycle.