Patent ID: 7192974

Claim:
A compound of formula (I), wherein: R 1 a is —NH(C═W)R 5 or W is O or S; R 2 and R 3 are independently selected from H, F, Cl, CF 3 , OMe, SMe, Me and Et; R 1 is selected from hydrogen, halogen, cyano, (1–4C)alkyl, cyano(1–4C)alkyl, halo(1–4C)alkyl, dihalo(1–4C)alkyl, trihalo(1–4C)alkyl, amino, (1–4C)alkylamino, di-(1–4C)alkylamino, (1–4C)alkylthio, (1–4C)alkoxy, (1–4C)alkoxy(1–4C)alkyl, (2–4C)alkenyloxy, (2–4C)alkenyl, (2–4C)alkynyl, (3–6C)cycloalkyl, (3–6C)cycloalkeny and (1-4C)alkoxycarbonyl; and wherein at each occurrence of an R 1 substituent containing an alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl moiety each such moiety is optionally substituted on an available carbon atom with one, two, three or more substituents independently selected from F, Cl, Br, OH and CN; R 5 is selected from hydrogen, (2–6C)alkyl (optionally substituted by 1, 2 or 3 substituents independently selected from methyl, chloro, bromo, fluoro, methoxy, methylthio, azido and cyano), methyl (optionally substituted by 1, 2 or 3 substituents independently selected from methyl, chloro, bromo, fluoro, methoxy, methylthio, hydroxy, benzyloxy, ethynyl, (1–4C)alkoxycarbonyl, azido and cyano), 5-halo-2-thienyl, —N(R 6 )(R 7 ), —OR 6 , —SR 6 , (2–4C)alkenyl, -(1–8C)alkylaryl, per-halo(1–8C)alkyl, —(CH 2 )p(3–6C)cycloalkyl and —(CH 2 )p(3–6C)cycloalkenyl wherein p is 0, 1 or 2; R 6 and R 7 are independently selected from hydrogen, and (1–4C)alkyl (optionally substituted with one, two, three or more halogen atoms); wherein R 4 is either a hydroxymethyl substituent on C-4′ of the isoxazoline ring; or R 4 is a hydroxymethyl substituent on C-5′ of the isoxazoline ring and the stereochemistry at C-5′ of the isoxazoline ring and at C-5 of the oxazolidinone ring is selected, such that the compound of formula (I) is a single diastereomer; or a pharmaceutically acceptable salt, solvate or pro-drug thereof.