Patent ID: 7358238

Claim:
A compound of formula (II) wherein R 1 is aryl substituted with one or more of R 7 ; R 2 and R 3 together with the atoms to which they are connected forms a C 5 -C 10 cycloalkyl or C 5 -C 10 hetcycloalkyl, wherein the cycloalkyl and hetcycloalkyl rings independently are optionally substituted with one or more of R 8 ; or R 2 and R 3 are connected to one of the following ring systems at the carbon atoms marked with an asterix (*) wherein the ring systems independently are optionally substituted with one or more R 8 ; R 7 is cyano, C 1 -C 6 alkyl, C 2 -C 6 alkyloxy, trihalomethyl, trihalomethoxy, aryloxy, hetaryloxy, NR 9 R 10 , arylC 1 -C 6 alkyloxy, hetarylC 1 -C 6 alkyloxy, C 1 -C 6 alkyloxyC 1 -C 6 alkyl, aryloxyC 1 -C 6 alkyl, arylC 1 -C 6 alkyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, arylcarbonyl, hetarylcarbonyl, arylC 1 -C 6 alkylcarbonyl, hetarylC 1 -C 6 alkylcarbonyl, C 1 -C 6 alkyl-carboxy, arylcarboxy, hetarylcarboxy, arylC 1 -C 6 alkylcarboxy or hetarylC 1 -C 6 alkylcarboxy; R 8 is hydrogen, C 1 -C 6 alkyl, halo, aryl, hetaryl, arylC 1 -C 6 alkyl, NR 9 R 10 , trihalomethyl, trihalomethoxy, hydroxy, oxo, C 1 -C 6 alkyloxy, aryloxy, arylC 1 -C 6 alkyloxy, hetarylC 1 -C 6 alkyloxy, C 1 -C 6 alkyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, arylcarbonyl, arylC 1 -C 6 alkylcarbonyl, C 1 -C 6 alkylcarboxy, arylcarboxy or arylC 1 -C 6 alkylcarboxy; R 9 and R 10 independently are hydrogen, C 1 -C 6 alkyl, aryl or arylC 1 -C 6 alkyl wherein the alkyl and aryl groups independently are optionally substituted with one or more of R 11 ; with the proviso that R 9 and R 10 cannot both be hydrogen; or R 9 and R 10 together with the nitrogen to which they are attached, are forming a saturated or partially saturated cyclic, bicyclic or tricyclic ring system containing from 4 to 10 carbon atoms and from 0 to 2 additional heteroatoms selected from nitrogen, oxygen or sulfur, the ring system optionally being substituted with at least one of C 1 -C 6 alkyl, aryl, hetaryl, arylC 1 -C 6 alkyl, hydroxy, oxo, C 1 -C 6 alkyloxy, arylC 1 -C 6 alkyloxy, C 1 -C 6 alkyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, arylcarbonyl, arylC 1 -C 6 alkylcarbonyl, C 1 -C 6 alkylcarboxy, arylcarboxy or arylC 1 -C 6 alkylcarboxy; R 11 is C 1 -C 6 alkyl, oxo or halo; X is (CR 12 R 13 ) n , wherein R 12 and R 13 independently are hydrogen, oxo, hydroxy or C 1 -C 6 alkyl; and n is 1 or 2; or a salt thereof with a pharmaceutically acceptable acid or base, or optical isomer or mixture of optical isomers, racemic mixture, or tautomeric forms thereof.