Patent ID: 7846679

Claim:
A method for detecting the presence of a mutant mammalian Presenilin protein in a biological sample, the method comprising: (i) contacting the biological sample with an isolated antibody selected from: (a) an isolated antibody that specifically binds to a mutant mammalian Presenilin protein, wherein the mutant mammalian Presenilin protein has a mutation relative to a wild-type mammalian Presenilin, the mutation being selected from the group consisting of: M 146 L; H 163 R; A 246 E; L 286 V; and C 410 Y, and wherein the wild-type mammalian Presenilin has the amino acid sequence depicted in SEQ ID NO: 2 or 134; or (b) an isolated antibody raised against a mutant mammalian Presenilin protein, wherein the mutant mammalian Presenilin protein has a mutation relative to a wild-type mammalian Presenilin, the mutation being selected from the group consisting of: M 146 L; H 163 R; A 246 E; L 286 V; and C 410 Y, wherein the wild-type mammalian Presenilin has the amino acid sequence depicted in SEQ ID NO: 2 or 134, and wherein said isolated antibody specifically binds to said mutant mammalian Presenilin protein; (ii) incubating the sample and the antibody under conditions sufficient to induce binding of the antibody to the mutant mammalian Presenilin in the sample to form a complex; and (iii) detecting the complex.