Patent ID: 7648701

Claim:
A synthetic peptide, which comprises (a) a promiscuous helper T cell epitope, (b) an IgE-CH3 domain antigen peptide, wherein said IgE-CH3 domain antigen peptide i) is 25 amino acids in length ii) contains two cysteine residues separated by 23 amino acid residues, and iii) is selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:84, wherein from one to four of the residues in SEQ ID NO:5 is conservatively substituted; and optionally (c) an immunostimulatory invasin domain, SEQ ID NO: 13, wherein the synthetic peptide induces anti-IgE antibody production in a mammal.