Patent ID: 7247319

Claim:
A method for processing microparticles to improve flowability, comprising: (a) conditioning the microparticles to form conditioned microparticles, wherein the microparticles comprise an active agent selected from the group consisting of risperidone, 9-hydroxyrisperidone, and pharmaceutically acceptable salts of the foregoing, a polymer selected from the group consisting of poly(glycolic acid), poly-d,l-lactic acid, poly-l-lactic acid, and copolymers of the foregoing, wherein the conditioning is carried out by maintaining the microparticles at a conditioning temperature of about 25° C. for a period of at least about 5 days; (b) measuring a flowability index of the conditioned microparticles; and (c) if the flowability index of the conditioned microparticles is not greater than about 60, repeating step (a) until the flowability index of the conditioned microparticles is greater than about 60.