Patent ID: 7632921

Claim:
The conjugate comprising a functional factor VIII polypeptide comprising a mutated factor VIII amino acid sequence in which the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:4 is mutated such that a non-cysteine residue at one of the factor VIII amino acid positions 81, 129, 377, 378, 468, 487, 491, 504, 556, 570, 1648, 1795, 1796, 1803, 1804, 1808, 1810, 1864, 1911, 2091, 2118 and 2284 with reference to the mature, full-length human factor VIII amino acid sequence of SEQ ID NO:4 is replaced with a cysteine residue such that a mutant cysteine residue exists, wherein the functional factor VIII polypeptide is covalently attached to a biocompatible polymer at the mutant cysteine residue.