Patent ID: 7714138

Claim:
A compound having Formula I: or an enantiomer, diastereomer, or pharmaceutically acceptable salt thereof wherein: R 1 is alkyl, substituted alkyl, phenyl, or substituted phenyl; each R 2 is independently H, halogen, cyano, NO 2 , OR 5 , NR 6 R 7 , alkyl, and/or haloalkyl; B is O, NR 8 , NR 8 CH 2 , S, SO, SO 2 , or CR 9 R 10 ; V is NR 11 or —(CR 37 R 38 ) p — provided that when V is NR 11 , R 1 is alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl; W and X are each CH; Y is O, S, or NR 12 ; Z is —CR 13 R 14 — or —(CR 13 R 14 ) 1 NR 15 —; 1 is 0 to 2; n is 0 to 4 if W and X are both CH, 0 to 3 if only one of X and W is N, and 0 to 2 if X and W are both N; p is 1 to 4; R 3 , R 5 , R 6 , R 7 , R 8 , R 11 , R 12 , and R 15 are independently H and/or alkyl; R 9 and R 10 are independently H, halogen, alkyl, and/or hydroxyalkyl; R 13 and R 14 are independently H, halogen, alkyl, haloalkyl, and/or hydroxyalkyl, or taken together with the carbon atom to which they are attached to form a carbocyclic or heterocyclic ring of 3 to 8 atoms; A is: R 16 , R 17 , R 18 , and R 19 are independently H, halogen, NR 30 R 31 , OR 32 , CO 2 R 33 , CONR 34 R 35 , SO 2 R 36 , alkyl, haloalkyl, hydroxyalkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, —CN, aryl, substituted phenyl and pyridinyl, and/or substituted heteroaryl; R 30 , R 31 , R 32 , R 33 , R 34 , R 35 , and R 36 are independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, alkoxycarbonyl, aryl, substituted phenyl and pyridinyl, substituted heteroaryl, heterocyclo, and/or substituted heterocyclo; and R 37 and R 38 are each independently H, halogen, and/or alkyl; wherein: said substituted alkyl, said substituted cycloalkyl, said substituted alkenyl, and said substituted alkynyl are substituted with one or more substituents independently selected from phenyl, halophenyl, amino, amido, —CN, —C(═O)OH, —C(═O)OCH 3 , halogen, hydroxy, and alkoxy; and said substituted phenyl, said substituted pyridinyl, and said heterocyclo are substituted with one or more substituents independently selected from alkyl, haloalkyl, hydroxyalkyl, alkoxy, —CN, halogen, phenyl, halophenyl, hydroxy, and amino.