Patent ID: 8540965

Claim:
A method of treating a pathophysiological state in a subject, comprising: administering a soluble single wall carbon nanotube (SWNT) construct functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereon, wherein the SWNT construct has a structure of SWNT-(DNA 1,2 -(cDNA 1 -peptide) m -(cDNA 2 -M*tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)) n ) x , such that cDNA 1 is linked to the peptide, cDNA 2 is linked to DOTA and DNA 1,2 is linked to the SWNT; and, wherein cDNA 1 and cDNA 2 independently are non-identical oligomers and DNA 1,2 is an oligomer with a sequence complementary to cDNA 1 and cDNA 2 ; and, wherein said DNA 1,2 is the sequence shown in SEQ ID NO: 1, said cDNA 1 is the sequence shown in SEQ ID NO: 2, and said cDNA 2 is the sequence shown in SEQ ID NO: 3; and, wherein said peptide is an antibody or a targeting cyclic RGD or an NGR peptide ligand, M* is a radionuclide, x is 1 to 300; and m and n are independently 1 to 300; and wherein, upon targeting cells associated with the pathophysiological state with said targeting moiety, said payload has a therapeutic effect against said cells or elicits a therapeutic effect from said cells thereby treating the pathophysiological state in the subject.