Patent ID: 8524906

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: each of X 1 and X 2 is, independently, N or CH; R 1 is —C(O)H, —C(O)R 1a , —C(O)N(R 1a )(R 1b ), or a 5- or 6-membered heteroaryl ring having 1-3 heteroatoms selected from N, O, or S and optionally substituted with 1, 2 or 3 J R2 groups; R 1a is C 1-6 aliphatic, C 3-6 cycloaliphatic, azetidinyl, pyrrolidinyl, or piperidinyl, wherein R 1a is optionally substituted with 1, 2, 3, or 4, occurrences of J R ; R 1b is hydrogen, C 1-4 aliphatic, or R 1a and R 1b , together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring, wherein said heterocyclic ring of R 1a and R 1b optionally comprises one additional heteroatom selected from nitrogen and oxygen, and wherein said heterocyclic ring of R 1a and R 1b is optionally substituted with 1 or 2 J R2 groups; each J R is independently fluoro, oxo, —C(O)J R1 , —C(O)N(J R1 ) 2 , —C(O)O(J R1 ), —N(J R1 )C(O)J R1 , —OJ R1 , —SJ R1 , phenyl or a 5-6 membered heteroaryl or heterocyclyl having up to 2 atoms selected from nitrogen, oxygen, or sulfur, wherein said phenyl, heteroaryl, or heterocyclyl or J R is optionally substituted with 1 or 2 J R2 groups; each J R1 is independently selected from hydrogen, C 1-4 aliphatic, C 3-6 cycloaliphatic, phenyl, benzyl, heterocyclyl, or heteroaryl, wherein said heterocyclyl of J R1 is a 5- or 6-membered ring having 1 or 2 atoms selected from N, or O, said heteroaryl of R 2 is a 5- or 6-membered monocyclic ring or a 9- or 10-membered fused bicyclic ring system having 1, 2, or 3 atoms selected from N, O, or S, and each of said aliphatic, cycloaliphatic, phenyl, benzyl, heterocyclyl, or heteroaryl of J R1 is optionally substituted with up to three J R2 groups; each J R2 is selected from chloro, fluoro, oxo, C 1-2 alkyl, C 1-2 alkyl substituted with 1-3 fluorine atoms, C 3-6 cycloalkyl, —OH, —OC 1-2 alkyl, —OC 1-2 alkyl substituted with 1-3 fluorine atoms, —C(O)C 1-2 alkyl, or —SC 1-2 alkyl; R 2 is hydrogen, fluoro, chloro, C 1-6 aliphatic, —OC 1-6 aliphatic, C 3-6 cycloaliphatic, —OC 3-6 cycloaliphatic, cyano, —NH 2 , —NHC 1-6 aliphatic, —NHC 3-6 cycloaliphatic, —NHS(O) 2 C 1-6 aliphatic, —NHS(O) 2 C 3-6 cycloaliphatic, —NHS(O) 2 phenyl, —NHS(O) 2 benzyl, —NHS(O) 2 heteroaryl, —S(O) 2 C 1-6 aliphatic, —S(O) 2 C 3-6 cycloaliphatic, —S(O) 2 phenyl, —S(O) 2 benzyl, —S(O) 2 heteroaryl, —S(O) 2 NHC 1-6 aliphatic, —S(O) 2 NHC 3-6 cycloaliphatic, —S(O) 2 NHphenyl, —S(O) 2 NHbenzyl, or —S(O) 2 NHheteroaryl, wherein said heteroaryl of R 2 is a 5- or 6-membered ring having 1, 2, or 3 atoms selected from N, O, or S, and wherein said aliphatic, cycloaliphatic, phenyl, benzyl, or heteroaryl of R 2 is optionally substituted with 1, 2, or 3 J R2 groups; and R 3 is hydrogen, fluoro, chloro, C 1-3 aliphatic, —OC 1-3 aliphatic, NH 2 , or NHC 1-3 aliphatic, wherein said aliphatic of R 3 is optionally substituted with up to 3 occurrences of fluoro.