Patent ID: 6932967

Claim:
A composition for aerosol administration by inhalation, comprising polyclonal monomeric IgA having a recombinant J chain and a recombinant secretory component in a molar ratio of the IgA to the J chain of 2:1 and a molar ratio of an IgA-J chain conjugate to the secretory component of 1:1, wherein the J chain and secretory component are sequentially combined with the IgA, and wherein the IgA comprises a by-product of cold ethanol fractionation of pooled plasma derived from more than one human individual, wherein the by-product is prepared by: providing pooled human plasma; fractionating the pooled human plasma to produce an IgA rich fraction; adsorbing the IgA rich fraction onto an ion exchange medium to form a bound portion of the IgA; recovering the bound portion of the IgA; subjecting the recovered bound portion of the IgA to antiviral treatment; and sterlizing the resulting product.