Patent ID: 7452881

Claim:
A process for preparing a derivative of sulphonamide with the general formula (I) wherein A represents a substituent selected from among: A heteroaromatic ring of 5 or 6 members containing 1 or 2 heteroatoms selected from among oxygen, nitrogen and sulphur, optionally substituted by 1 or 2 halogen atoms, by a C 1 -C 4 alkyl radical or by a phenyl radical or a heteroaryl radical with 5 or 6 members containing 1 or 2 atoms of oxygen, nitrogen or sulphur; A bicyclic heteroaromatic ring containing 1 to 3 heteroatoms selected from among oxygen, nitrogen and sulphur, optionally substituted by 1 or 2 halogen atoms or by a C 1 -C 4 alkyl radical; A group selected from among: R 1 represents hydrogen, a C 1 -C 4 alkyl radical or a benzyl radical; n represents 0, 1, 2, 3 or 4; R 2 represents —NR 4 R 5 or a group with formula: wherein the dotted line represents an optional chemical bond; and R 3 , R 4 y R 5 independently represent hydrogen or a C 1 -C 4 alkyl; X, Y and Z independently represent hydrogen, fluorine, chlorine, bromine, a C 1 -C 4 alkyl, a C 1 -C 4 alkoxy, a C 1 -C 4 alkylthio, trifluoromethyl, cyano, nitro and —NR 4 R 5 ; W represents a bond between the two rings, CH 2 , O, S and NR 4 ; m represents 0, 1, 2, 3 or 4; with the condition that when m=0, A is a substituted phenyl; or one of its physiologically acceptable salts; said process comprising the steps of: reacting a compound with the general formula (II), or one of its suitably protected derivatives, wherein A is as indicated previously in the general formula (I), and X is a suitable leaving group including an halogen atom, particularly chlorine; with a 5-aminoindole with the general formula (III), or one of its suitably protected derivatives; wherein n, R 1 , R 2 and R 3 are as indicated above in the general formula (I); in order to obtain the corresponding sulphonamide, and optionally it is possible to remove eventually the protective groups from it.