Patent ID: 8530670

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, including all tautomers and stereoisomers thereof wherein: R 1 represents hydrogen, halogen, —C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, -aryl, —C 1-6 alkylaryl, -cycloalkyl, —C 1-6 alkylcycloalkyl, -heteroaryl, —C 1-6 alkylheteroaryl, -heterocyclyl, —C 1-6 alkylheterocyclyl, -cycloalkyl substituted by phenyl, -cycloalkyl substituted by phenoxy, -phenyl substituted by cycloalkyl, -phenyl substituted by phenoxy, -phenyl substituted by phenyl, heterocyclyl substituted by phenyl, heteroaryl substituted by phenyl, phenyl substituted by heterocyclyl, phenyl substituted by heteroaryl, phenyl substituted by —O-cycloalkyl, phenyl substituted by -heterocyclyl-phenyl or phenyl substituted by -cycloalkyl-heterocyclyl; and in which any of aforesaid aryl, cycloalkyl, heterocyclyl, heteroaryl, phenyl or phenoxy groups may optionally be substituted by one or more R b groups selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —C 1-6 thioalkyl, —SOC 1-4 alkyl, —SO 2 C 1-4 alkyl, C 1-6 alkoxy-, C 1-6 haloalkoxy, —O—C 3-8 cycloalkyl, C 3-8 cycloalkyl, —SO 2 C 3-8 cycloalkyl, —SOC 3-6 cycloalkyl, C 3-6 alkenyloxy-, C 3-6 alkynyloxy-, —C(O)C 1-6 alkyl, —C(O)OC 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl-, nitro, halogen, cyano, hydroxyl, ═O, —C(O)OH, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 -alkyl)(C 1-4 -alkyl), —C(O)N(C 1-4 -alkyl)(C 1-4 -alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 -alkyl) and —C(O)NH(C 3-10 cycloalkyl); R 2 represents ═O, —O—C 1-6 alkyl, —NR 3 R 4 or —O—C 1-6 haloalkyl, wherein if R 2 is ═O, the dashed line and solid line is a single bond and if R 2 is −O—C 1-6 alkyl, —NR 3 R 4 or —O—C 1-6 haloalkyl, the dashed and solid line is a double bond; R 3 and R 4 independently represent hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl; or R 3 and R 4 together with the nitrogen atom to which they are attached may form a heterocyclyl group optionally substituted by one or more R b groups; n represents an integer selected from 0 to 3; and R a represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —C 1-6 thioalkyl, —SOC 1-4 -alkyl, —SO 2 C 1-4 alkyl, C 1-6 alkoxy-, —O—C 3-8 cycloalkyl, C 3-8 cycloalkyl, —SO 2 C 3-8 cycloalkyl, —SOC 3-6 cycloalkyl, C 3-6 alkenyloxy-, C 3-6 alkynyloxy-, —C(O)C 1-6 alkyl, —C(O)OC 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 -alkyl)(C 1-4 -alkyl), —C(O)N(C 1-4 -alkyl)(C 1-4 -alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl) and —C(O)NH(C 3-10 cycloalkyl).