Patent ID: 7049332

Claim:
An N-aminoimidazole or N-aminoimidazolethione derivative, a pharmaceutically acceptable salt, a tautomer, an isomer, an ester or a glycosylation product thereof said derivative being a compound represented by the general formula (I): wherein: m is zero or 1; n is zero or 1; R 1 is selected from hydrogen, methyl, ethyl, propyl or isopropyl; R 2 is selected from hydrogen and —SH; Q is selected from 1-naphtyl, 2-naphtyl, biphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, thienyl, carboxyl, aminocarbonyl, alkylamino-carbonyl, dialkylaminocarbonyl, phenylaminocarbonyl, alkyloxycarbonyl or phenyl; wherein alkyl is a methyl, ethyl, propyl or isopropyl and phenyl is a substituted or unsubstituted phenyl ring represented by the general formula (II) wherein o is 1 or 2, and R 3 is selected from H, F, Cl, Br, I, hydroxy, alkyloxy, amino, alkylamino, dialkylamino, cyano, nitro, carboxyl, aminocarbonyl, alkylaminocarbonyl, alkyloxycarbonyl, methyl, ethyl, propyl, isopropyl or C 1-3 haloalkyl wherein haloalkyl contains 1 to 4 haloatoms and alkyl is selected from methyl, ethyl, propyl or isopropyl; L is selected from 1-naphtyl, 2-naphtyl, biphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, thienyl, or a substituted or unsubstituted phenyl ring represented by the general formula (III) wherein p is 1 or 2, and R 4 is selected from H, F, Cl, Br, I, hydroxy, alkyloxy, amino, alkylamino, dialkylamino, cyano, nitro, carboxyl, aminocarbonyl, alkylaminocarbonyl, alkyloxycarbonyl, methyl, ethyl, propyl, isopropyl or C 1-3 haloalkyl wherein haloalkyl contains 1 to 4 haloatoms and alkyl is selected from methyl, ethyl, propyl or isopropyl; with the proviso that the compound (I) is not selected from 1-(3-Chlorophenylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(2-Chlorophenylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(4-Chlorophenylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(phenylamino)-2,3-Dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(4-nitrophenylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(4-methylphenylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(4-methyloxyphenylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 1-(benzylamino)-2,3-dihydro-4-methyl-5-phenyl-1H-imidazole-2-thione; 4-Methyl-5-phenyl-1-phenylamino-1H-imidazole; 4-Methyl-5-phenyl-1-(4-nitrophenyl)amino-1H-imidazole; 4-Methyl-5-phenyl-1-(4-chlorophenyl)amino-1H-imidazole; 4-Methyl-5-phenyl-1-(4-methylphenyl)amino-1H-imidazole or 4-Methyl-5-phenyl-1-(4-methyloxyphenyl)amino-1H-imidazole.