Patent ID: 6933288

Claim:
A compound of the formula (I): where R 1 is —NR 8 R 9 or —C(R 10 ) 3 ; R 2 is —NR 17 R 18 ; R 3 and R 7 each independently are —NR 11 R 12 , —YZ, alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, alkylenearyl, halo, or H radical; each R 5 independently is alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, —(CH 2 ) n N(R 11 R 12 ), —(CH 2 ) n G or H; R 6 is an electron pair, alkyl, cycloalkyl, aryl, heteroaryl or H; R 4 , R 11 , R 12 , R 15 , R 16 and R 17 each independently are alkyl, cycloalkyl, aryl, heteroaryl or H; R 8 and R 9 each independently are alkyl, cycloalkyl, aryl, heteroaryl, H or together join to form an aminocyclic ring radical; each R 10 independently is alkyl, cycloalkyl, aryl, heteroaryl, halo or H; R 13 and R 14 are each hydroxyl; R 18 is alkyl, cycloalkyl, aryl, heteroaryl, 2-(dimethylamino)ethyl, propyl-L 1 , or methyl-L 2 where L 1 is dimethylamino, 1-methylpiperazinyl, or pyrrolidinyl and L 2 is phenyl, 3,4-dimethylphenyl, 2-methylfuranyl, or cyano; Y is a heteroatom radical with Z a radical selected from the group comprising 1 or more heteroatoms or H, alkyl, cycloalkyl, aryl, heteroaryl, halo, combinations thereof and adapted to fill the valence of Y, said Y being singly or doubly bound to the pyrimidine ring radical; Q is a member selected from the group of radicals comprising —S(═O)—, —S(O) 2 —, —C(═O)—, —C(═S)—, —CH 2 —, —Y(O)— and —C(Y) n —; where G is a cyclic alkyl or cyclic heteroalkyl substituent and n is an integer of at least 0; and with the proviso that; when R 2 is NH 2 and R 9 is H, then; R 8 is not an amino acid and; the ratio of carbon atoms to nitrogen atoms of R 5 is greater than or equal to one and; R 16 is H radical and; R 15 does not comprise a radical.