Patent ID: 7109215

Claim:
A compound of the formula: and pharmaceutically acceptable derivatives thereof; wherein: at least one of A or B is a (C1–C6)-alkyl chain terminally substituted with phenyl or pyridinyl; the other of A or B is independently selected from hydrogen, Ar, (C 1 –C 6 )-straight or branched alkyl, (C 2 –C 6 )-straight or branched alkenyl or alkynyl, Ar-substituted-(C 1 –C 6 )-straight or branched alkyl, or Ar-substituted-(C 2 –C 6 )-straight or branched alkenyl or alkynyl; wherein any one of the CH 2 groups of said alkyl, alkenyl or alkynyl chains in A or B is optionally replaced by O; Ar is selected from phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, or thiazolyl, and wherein each Ar is optionally substituted with one to three substituents independently selected from halogen, hydroxyl, nitro, —SO 3 H, trifluoromethyl, trifluoromethoxy, (C 1 –C 6 )-straight or branched alkyl, (C 2 –C 6 )-straight or branched alkenyl, O—[(C 1 –C 6 )-straight or branched alkyl], O—[C 2 –C 6 )-straight or branched alkenyl], O-benzyl, O-phenyl, 1,2-methylenedioxy, —N(R 1 )(R 2 ), carboxyl, N—(C 1 –C 5 -straight or branched alkyl or C 2 –C 5 -straight or branched alkenyl) carboxamide, N,N-di-(C 1 –C 5 -straight or branched alkyl or C 2 –C 5 -straight or branched alkenyl) carboxamide, N—(C 1 –C 5 -straight or branched alkyl or C 2 –C 5 -straight or branched alkenyl) sulfonamide, N,N-di-(C 1 –C 5 -straight or branched alkyl or C 2 –C 5 -straight or branched alkenyl) sulfonamide, morpholinyl, piperidinyl, O-Z, CH 2 —(CH 2 ) q -Z, O—CH 2 ) q -Z, (CH 2 ) q -Z-O-Z, or CH═CH-Z; wherein R 1 and R 2 are independently selected from (C 1 –C 6 )-straight or branched alkyl, (C 2 –C 6 )-straight or branched alkenyl or alkynyl, hydrogen or benzyl; or wherein R 1 and R 2 are taken together with the nitrogen atom to which they are bound to form a 5–7 membered heterocyclic ring; Z is selected from 2-pyridyl, 3-pyridyl, or 4-pyridyl; and q is 0, 1 or 2; R 3 is selected from (C 1 C 6 )-alkyl, (C 1 C 6 )alkyl terminally substituted with pyridyl, or 3,4,5-trimethyoxybenzoylmethyl; X is N or O; wherein when X is N, Y is selected from hydrogen, Ar, (C 1 –C 6 )-straight or branched alkyl, (C 2 –C 6 )-straight or branched alkenyl or alkynyl, Ar-substituted-(C 1 –C 6 )-straight or branched alkyl, or Ar-substituted-(C 2 –C 6 )-straight or branched alkenyl or alkynyl; when X is O, Y is a lone pair of electrons; n is 0; m is 2; and the indicated ring is fully saturated.