Patent ID: 8883414

Claim:
A method of identifying an individual with one or more human chromosomal abnormalities, said method comprising: (a) obtaining a sample from an individual, said sample comprising genetic material from cervical tissue and/or fluid thereof; (b) hybridizing a probe set with the genetic material, wherein hybridizing comprises fluorescence in situ hybridization (FISH), and wherein the probe set consists of (i) a first probe that hybridizes selectively to 3q26, said first probe comprising a probe preparation of seven different nick-translated clones corresponding to chromosome 3, clones 1-7 of Table 4, (ii) a second probe that hybridizes selectively to 5p15, said second probe comprising a probe preparation of five different nick-translated clones corresponding to chromosome 5, clones 1-5 of Table 4, (iii) a third probe that hybridizes selectively to 20q13, said third probe comprising a probe preparation of three different nick-translated clones corresponding to chromosome 20, clones 1-3 of Table 4, and (iv) a fourth probe that hybridizes selectively to cen7, said fourth probe comprising a probe preparation of a nick-translated clone corresponding to chromosome 7, clone 1 of Table 4; and (c) analyzing the hybridization pattern of the probe set to the genetic material to determine the presence or absence in the sample of a gain of 3q, a gain of 5p, a gain of 20q, and a gain of cen7.