Patent ID: 8257936

Claim:
A method of detecting a change in a cell growth pattern comprising: a) adding one or more cells that express one or more adhesion proteins on their surface to a colorimetric resonant reflectance optical biosensor, wherein one or more antibodies or binding fragments thereof are immobilized on one or more locations on the biosensor surface, wherein the antibodies or binding fragments thereof specifically bind to the one or more adhesion proteins; b) detecting a first colorimetric resonant reflectance optical peak wavelength value (PWV) for the one or more locations; c) incubating the one or more cells for a period of time or applying a test reagent to the one or more cells and incubating the one or more cells for a period of time; d) detecting a second PWV for the one or more locations; and e) comparing the first PWV and second PWV; wherein a difference between the first PWV in relation to the second PWV indicates a change in the cell growth pattern in the one or more cells.