Patent ID: 8575363

Claim:
A compound of Formula (I) wherein Y is a C 6-10 aryl or a heteroaryl selected from the group consisting of thiazolyl, thienyl, benzofuranyl, and benzothienyl; wherein Y is unsubstituted or substituted with one or two fluoro substituents; Z is i) a C 6-10 aryl; ii) 9H-fluorenyl; iii) phenyl-(R a )-phenyl wherein the phenyl ring on phenyl-(R a )— is unsubstituted or substituted with one substituent that is trifluoromethyl; R a is CH(F), CF 2 , or CH(OH); iv) a benzo-fused heterocyclyl selected from the group consisting of 1,2,3,4-tetrahydroisoquinolinyl, isoindolinyl, and indolinyl; wherein the benzo-fused heterocyclyl is unsubstituted or substituted with one substituent that is phenyl or bromo, wherein said phenyl is unsubstituted or substituted with one substituent selected from the group consisting of bromo, chloro, fluoro, methyl, methoxy, or trifluoromethyl; or v) a heteroaryl selected from the group consisting thiazolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinazolinyl, indolyl, and indazolyl; wherein the C 6-10 aryl and the heteroaryl of Z are unsubstituted or substituted with one or two substitutents each of which is independently selected from the group consisting of bromo, chloro, fluoro, C 1-4 alkyl, C 2-4 alkenyl, trifluoromethyl, trifluoromethoxy, and R b ; provided that no more than one substituent is R b ; and R b is selected from the group consisting of 2,2-difluoroethyl; phenylmethyl; C 3-6 cycloalkyl; N-methyl-N-phenylaminocarbonyl-methyl; thienyl; pyrimidinyl; and phenyl; wherein the phenyl portion of phenylmethyl, and said thienyl, pyrimidinyl, and phenyl of R b are unsubstituted or substituted with one or two substituents each of which is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, chloro, and fluoro; R 1 is hydrogen, fluoro or hydroxy; R 2 is hydrogen, methyl, or hydroxy; and enantiomers, diastereomers, and pharmaceutically acceptable salt forms thereof.