Patent ID: 7220771

Claim:
A method for treating cancer of the blood, brain, lung or prostate by inhibiting JNK pathway comprising administering to a patient in need thereof an effective amount of a compound having the structure: or a pharmaceutically acceptable salt thereof, wherein: A-R 1 is phenyl, optionally substituted with one to four substituents independently selected from halogen, alkoxy, —NR 8 C(═O)R 9 , —C(═O)NR 8 R 9 , and —O(CH 2 ) b NR 8 R 9 ; R 2 is 3-triazolyl or 5-tetrazolyl; b is 2 or 3; R 8 and R 9 are the same or different and at each occurrence independently hydrogen, alkyl, aryl, arylalkyl, heterocycle, or heterocyclealkyl, or R 2 and R 9 taken together with the atom or atoms to which they are bonded from a heterocycle, wherein each of R 8 , R 9 , and R 8 and R 9 taken together to form a heterocycle are optionally substituted with one to four substituents independently selected from R 3 ; R 3 is at each occurrence independently halogen, hydroxy, carboxy, alkyl, alkoxy, haloalkyl, acyloxy, thioalkyl, sulfinylalkyl, sulfonylalkyl, hydroxyalkyl, aryl, substituted aryl, aryalkyl, substituted aryalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, or substituted heterocyclealkyl.