Patent ID: 8153635

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof; in which: Q is a divalent radical selected from C 6-10 aryl, C 3-10 heteroaryl, C 3-8 cycloalkyl and C 3-8 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl or heterocycloalkyl of Q is optionally substituted with up to 3 radicals independently selected from halo, C 1-6 alkyl, halo-substituted-C 1-6 alkyk C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, —C(O)R 20 and —C(O)OR 20 ; wherein R 20 is selected from hydrogen and C 1-6 alkyl; ring A can have one ring carbon replaced by a —C(O)—; L is selected from C 1-6 alkylene, C 2-6 alkenylene, —(CH 2 ) n O—, —OC(O)(CH 2 ) n —, —C(O)O(CH 2 ) n —, —NR 26 (CH 2 ) n — and —O(CH 2 ) n —; wherein R 26 is selected from hydrogen and C 1-6 alkyl; n is selected from 0, 1, 2, 3, 4 and 5; any alkyl of L can be optionally substituted with 1 to 3 radicals independently selected from halo, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, —C(O)R 22 and —C(O)OR 22 ; wherein R 22 is selected from hydrogen and C 1-6 alkyl; m is selected from 0, 1, 2, 3 and 4; q is selected from 0, 1, 2, 3 and 4; R 1 is selected from —X 1 S(O) 0-2 X 2 R 6a , —X 1 S(O) 0-2 X 2 OR 6a , —X 1 S(O) 0-2 X 2 C(O)R 6a , —X 1 S(O) 0-2 X 2 C(O)OR 6a , —X 1 S(O) 0-2 X 2 OC(O)R 6a and —X 1 S(O) 0-2 NR 6a R 6b ; wherein X 1 is selected from a bond, O, NR 7a and C 1-4 alkylene; wherein R 7a is selected from hydrogen and C 1-6 alkyl; X 2 is selected from a bond and C 1-4 alkylene; R 6a is selected from hydrogen, halo, C 1-6 alkyl, C 2-6 alkenyl, C 6-10 aryl, C 3-10 heteroaryl, C 3-8 heterocycloalkyl and C 3-8 cycloalkyl; wherein said aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R 6a is optionally substituted with 1 to 3 radicals independently selected from hydroxyl, halo, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, hydroxyl-substituted-C 1-6 alkyl, cyano-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy and C 6-10 aryl-C 1-4 alkoxy; and R 6b is selected from hydrogen and C 1-6 alkyl; R 2 and R 3 are independently selected from hydrogen, halo, hydroxyl, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, hydroxyl-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, —C(O)R 23 , and —C(O)OR 23 , wherein R 23 is selected from hydrogen and C 1-6 alkyl; R 4 is selected from R 8 and —C(O)OR 8 ; wherein R 8 is selected from C 1-6 alkyl, C 6-10 aryl, C 3-10 heteroaryl, C 3-8 cycloalkyl and C 3-8 heterocycloalkyl; wherein said aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 8 is optionally substituted with 1 to 3 radicals independently selected from halo, C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, halo-substituted-C 1-6 alkyl, hydroxyl-substituted-C 1-6 alkyl, C 1-6 alkoxy and halo-substituted-C 1-6 alkoxy; and R 5 is selected from hydrogen, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, hydroxyl-substituted-C 1-6 alkyl, C 1-6 alkoxy and halo-substituted-C 1-6 alkoxy.