Patent ID: 8846734

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein: R 1 is isopropyl or t-butyl; R 2 , R 4 and R 6 are independently H or methyl; R 3 is —CR a R b R c wherein R a is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally halogenated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl; and each of R b and R c is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; or R b and R c may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or hetero-form thereof, which may be optionally substituted; R 5 is an optionally substituted oxazole or thiazole ring; R 6 is H, or optionally substituted C1-C4 alkyl; Y is at one or more of positions 4, 5, 6 and 7, and Y′ is at one or more of positions 2,3 and 6, wherein the positions are as indicated in formula II: wherein R 6 is as defined in formula (I), and Y and Y′ is each independently halo, OH, C1-C4 alkoxy, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; m is 3, 2, 1 or 0; and m′ is 2, 1 or 0, wherein optionally substituted means, for alkyl, alkenyl and alkynyl groups: halo, OH, ═O, ═N—CN, ═N—OR, ═NR, OR, NR 2 , SR, SOR, SO 2 R, SO 2 NR 2 , NRSO 2 R, NRCONR 2 , NRCOOR, NRCOR, CN, COOR, CONR 2 , OOCR, COR, and NO 2 , wherein each R is independently H, optionally fluorinated C1-C8 alkyl, C1-C8 acyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, C5-C20 arylalkyl, or a heteroform of these and each R is optionally substituted with one or more groups selected from halo, OH, ═O, ═N—CN, ═N—OR′, ═NR′, OR′, NR′ 2 , SR′, SOR′, SO 2 R′, SO 2 NR′ 2 , NR′SO 2 R′, NR′CONR′ 2 , NR′COOR′, NR′COR′, CN, COOR′, CONR′ 2 , 00 CR′, COR′, and NO 2 , wherein each R′ is independently H, optionally fluorinated C1-C8 alkyl, C1-C8 acyl, C6-C12 aryl , C5-C20 arylalkyl, or a heteroform of these; and for aryl, heteroaryl and heterocyclyl groups: optionally fluorinated C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 acyl, and heteroforms of these, C6-C12 aryl, C6-20 arylalkyl, and heteroforms of these, each optionally substituted, or halo, OH, OR, CH 2 OH, CH 2 OR, CH 2 NR 2 , NR 2 , SR, SOR, SO 2 R, SO 2 NR 2 , NRSO 2 R, NRCONR 2 , NRCOOR, NRCOR, CN, COOR, CONR 2 , OOCR, C(O)R, and NO 2 , wherein each R is independently H, optionally fluorinated C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, C7-C20 arylalkyl, and heteroforms of these, and each R is optionally substituted, and wherein the prefix “hetero” means comprising 1-2 heteroatoms that are independently O, S or N.