Patent ID: 8410094

Claim:
A 8-(3 -aminopropyl)-3 -exo-8-azabicyclo(3.2.1)octane-3 -amino amide compound represented by the following formula I or a pharmaceutically acceptable salt thereof: wherein, R 1 is a group unsubstituted or substituted by 1 to 3 substituents and selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, phenyl, benzyl, naphthyl, and C 4 -C 7 saturated heterocyclic group, wherein the heterocyclic group comprises 1 to 3 hetero atoms selected from the group consisting of N, O and S, the substituents are atoms or groups selected from the group consisting of C 1 -C 6 alkyl, COR 7 and SO 2 R 7 ; X is OC(O), CO, NR 6 CO or SO 2 ; R 2 is a group unsubstituted or substituted by 1 to 3 substituents and selected from the group consisting of phenyl, benzyl and naphthyl, wherein the substituents are atoms or groups selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 7 cycloalkyl, halogen, and CF 3 ; R 3 is hydrogen, or R 3 together with the attached N, Y, R 4 and R 5 forms a group of 3-isopropyl-5-methyl-4-hydro- 1,2,4-triazol-4-yl; Y is C(O)O, CO, C(O)NR 6 or SO 2 ; R 4 is a direct bond or a group unsubstituted or substituted by 1 to 3 substituents and selected from the group consisting of C 1 -C 6 alkylene or C 1 -C 6 alkyleneoxy, wherein the substituents are atoms or groups selected from the group consisting of C 1 -C 6 alkoxy, halogen, amino, mercapto and hydroxyl; R 5 is a group unsubstituted or substituted by 1 to 3 substituents and selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, adamantyl, phenyl, phenoxyl, benzyl, naphthyl, C 5 -C 10 aromatic heterocyclic group and C 4 -C 7 saturated heterocyclic group, wherein the heterocyclic group comprises 1 to 3 hetero atoms selected from the group consisting of N, O and S, the substituents are atoms or groups selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, mercapto, hydroxyl, CF 3 , CN, NO 2 , NR 6 R 7 , NR 6 SO 2 R 7 , SO 2 R 7 and SO 2 NR 6 R 7 , or NR 6 R 7 forms a cycloamine group; R 6 is hydrogen, hydroxyl or C 1 -C 6 alkyl; R 7 is hydrogen or a group unsubstituted or substituted by 1 to 3 substituents and selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 3 -C 8 cycloalkyl, phenyl, benzyl, naphthyl, C 5 -C 10 aromatic heterocyclic group and C 4 -C 7 saturated heterocyclic group, wherein the heterocyclic group comprises 1 to 3 hetero atoms selected from the group consisting of N, O and S, the substituents are atoms or groups selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, amino, nitro group, mercapto, hydroxyl, CN and CF 3 .