Patent ID: 7297693

Claim:
A compound of formula (I): wherein: X is O, CH 2 , CO, S or NH, or the moiety X—R 1 is hydrogen; Y 1 and Y 2 independently represent CH or N; R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, arylC 1-6 alkyl-, heterocyclyl, heterocyclylC 1-6 alkyl-, heteroaryl, or heteroarylC 1-6 alkyl-, any of which, except hydrogen, may be optionally substituted; R 2 is CONR 6 R 7 ; R 6 and R 7 independently represent hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, arylC 1-6 alkyl, heteroaryl, heteroarylC 1-6 alkyl, heterocyclyl, or heterocyclylC 1-6 alkyl, any of which except for hydrogen may be optionally substituted, or R 6 and R 7 together with the nitrogen atom to which they are attached form a 3- to 12-membered monocyclic or bicyclic ring optionally including up to three heteroatoms selected from O, N or S wherein said ring may be optionally substituted; Ar is a group of the formula a) or b): wherein A represents a fused 5- to 7-membered ring optionally containing up to two heteroatoms selected from O, S and NR 5 , wherein R 5 is hydrogen or C 1-6 alkyl, which ring is optionally substituted by up to 2 substituents selected from halogen, C 1-6 alkyl, hydroxy, C 1-6 alkoxy or keto; R 3 and R 4 are independently selected from hydrogen, halogen, C 1-6 alkyl, aryl, arylC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, haloC 1-6 alkyl, arylC 1-6 alkoxy, hydroxy, nitro, cyano, azido, amino, mono- and di-N-C 1-6 alkylamino, acylamino, arylcarbonylamino, acyloxy, carboxy, carboxy salts, carboxy esters, carbamoyl, mono- and di-N-C 1-6 alkylcarbamoyl, C 1-6 alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, C 1-6 alkylguanidino, amidino, C 1-6 alkylamidino, sulphonylamino, aminosulphonyl, C 1-6 alkylthio, C 1-6 alkyl sulphinyl or C 1-6 alkylsulphonyl; and one of X 1 and X 2 is selected from O, S or NR 11 and the other is CH, wherein R 11 is hydrogen, C 1-6 alkyl, aryl or arylC 1-6 alkyl; or a pharmaceutically acceptable salt thereof.