Patent ID: 7456184

Claim:
A compound having the formula of structure I: or an enantiomer, stereoisomer or diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein X is CH 2 ; R 1 is -L 1 -J; one of R 2a and R 2b is -L 2 -W and the remaining of R 2a and R 2b is hydrogen; R 3 is -L 3 -Q; L 1 is a linker unit selected from the group consisting of —(CH 2 ) 2 —, —(CH 2 ) 3 —, —(CH 2 ) y —C(═O)—, —C(═O)—(CH 2 ) y — and —C(═O)—; J is a substituted or unsubstituted ring structure selected from the group consisting of wherein, when substituted, J is substituted with one or more ring substituents independently selected from the group consisting of hydroxyl, halogen, sulfonamide, alkyl or aryl groups attached directly or through an ether linkage; L 2 is —(CH 2 ) y —; W is —NH—C(═NH)—NH 2 ; L 3 is a linker unit selected from the group consisting of —(CH 2 ) y —CH(NR 6a R 6b )—(CH 2 ) y —, —(CH 2 ) y —C(═O)—CH(NR 6a R 6b )—(CH 2 ) y —, —(CH 2 ) y —C(═O)—, —(CH 2 ) y —CH(CH 3 )—C(═O)—, —C(═O)—(CH 2 ) y —C(═O)—, —C(═O)—CH(NR 6a R 6b )—(CH 2 ) y —, —C(═O)—(CH 2 ) y —, —C(═O)—(CH 2 ) y —CH(NR 6a R 6b )—, —C(═O)—(CH 2 ) y —CH(NR 6a R 6b )—(CH 2 ) y —, —C(═O)—(CH 2 ) y —CH(NHR 6a R 6b )—C(═O)— and —C(═O)—; R 6a and R 6b are each hydrogen; Q is wherein R 9a and R 9b are ring substituents, wherein one or both are present and are the same or different and are independently hydroxyl, halogen, alkyl, or aryl groups attached directly or through an ether linkage; R 5a is a C 1 to C 6 aliphatic linear or branched chain; R 5b is hydrogen; and each of R 4a and R 4b is hydrogen; and y is at each occurrence independently from 1 to 6, provided that where any linker unit includes two y index values, the total of such y index values is from 2 to 6.