Patent ID: 7642281

Claim:
A method of treating a subject suffering from a memory impairment comprising administering to the subject an amount of a compound effective to enhance the subject's memory, wherein the compound has the structure: wherein each of Y 1 , Y 2 , Y 3 , and Y 4 is independently —H; straight chained or branched C 1 -C 7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C 2 -C 7 alkenyl or alkynyl; C 3 -C 7 cycloalkyl, or C 5 -C 7 cycloalkenyl; —F, —Cl, —Br, or —I; —NO 2 ; —N 3 ; —CN; —OR 4 , —SR 4 , —OCOR 4 , —COR 4 , —NCOR 4 , —N(R 4 ) 2 , —CON(R 4 ) 2 , or —COOR, 4 ; aryl or heteroaryl; or any two of Y 1 , Y 2 , Y 3 , and Y 4 present on adjacent carbon atoms can constitute a methylenedioxy group; wherein each R 4 is independently —H; straight chained or branched C 1 -C 7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C 2 -C 7 alkenyl or alkynyl; C 3 -C 7 cycloalkyl, C 5 -C 7 cycloalkenyl, aryl or aryl(C 1 -C 6 )alkyl; wherein A is A′, straight chained or branched C 1 -C 7 alkyl, aryl, heteroaryl, aryl(C 1 -C 6 )alkyl or heteroaryl(C 1 -C 6 )alkyl; wherein A′ is wherein R 1 and R 2 are each independently —H, straight chained or branched C 1 -C 7 alkyl, —F, —Cl, —Br, —I, —NO 2 , or —CN; wherein R 3 is —H, straight chained or branched C 1 -C 7 alkyl, —F, —Cl, —Br, —I, —NO 2 , —CN, —OR 6 aryl or heteroaryl; wherein R 5 , is straight chained or branched C 1 -C 7 alkyl, —N(R 4 ) 2 —, OR 6 , or aryl; wherein R 6 is straight chained or branched C 1 -C 7 alkyl or aryl; wherein B is aryl, or heteroaryl; provided however, if B is aryl or heteroaryl the carbon atom or carbon atoms ortho to the nitrogen atom of the imine bond may only be substituted with one or more of the following: —H, —F, —Cl, —Br, —I, —CN, methyl, ethyl or methoxy; wherein each n is independently an integer from 1 to 4 inclusive; wherein the compound is a pure Z imine isomer, a pure E imine isomer, or a mixture of Z and E imine isomers; or a pharmaceutically acceptable salt thereof.