Patent ID: 8008354

Claim:
A method to enhance TNF-family death receptor ligand-mediated killing of tumor cells in a mammal, comprising administering to a mammal having TNF-family death receptor ligand-resistant cancer an effective amount of a compound of formula (I): wherein, R 1 is alkylene, alkenylene, arylene, heteroarylene, heterocyclene or cycloalkylene; R a is F, Cl, Br or I; R 9 is O or NR x ; each R zz is independently O, NR x or S; R 10 is alkyl, alkenyl, alkoxy, halo, haloalkyl, hydroxy, hydroxyalkyl, heteroaryl, heterocycle, cycloalkyl, amino, alkylamino, NR x R y or COOR x ; and each R x and R y is independently H, alkyl, alkenyl, aryl, heteroaryl, heterocycle, cycloalkyl or hydroxyl; or a pharmaceutically acceptable salt thereof.