Patent ID: 7517899

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof wherein: the dotted line between Y and Z represents an optional double bond; the dotted line between the two R 4 groups represents an optional heterocyclic ring of 4 to 6 ring atoms that may be formed between the two R 4 groups, together with the nitrogen through which they are attached; Y is CR 6 , or C═O; Z is N, NR 7 , CR 5 , or C(R 5 ) 2 ; R 1 is, independently at each occurrence, alkyl, alkoxy, halo, CF 3 , OCF 3 , arylalkyloxy substituted with 0-3 R 11 , aryloxy substituted with 0-3 R 11 , aryl substituted with 0-3 R 11 , heteroaryl substituted with 0-3 R 11 , hydroxy, alkanoyloxy, nitro, nitrile, alkenyl, alkynyl, alkylsulfoxide, phenylsulfoxide substituted with 0-3 R 11 , alkylsulfone, phenylsulfone substituted with 0-3 R 11 , alkylsulfonamide, phenylsulfonamide substituted with 0-3 R 11 , heteroaryloxy substituted with 0-3 R 11 , heteroarylmethyloxy substituted with 0-3 R 11 , alkylamido, or arylamido substituted with 0-3 R 11 ; or two adjacent R 1 also represent methylenedioxy; R 2 is aryl substituted with 0-3 R 1 or heteroaryl substituted with 0-3 R 1 ; R 3 is H or C 1 -C 4 alkyl; R 4 is, independently at each occurrence, H, C 1 -C 4 alkyl, arylalkyl, heteroarylmethyl, cycloheptylmethyl, cyclohexylmethyl, cyclopentylmethyl, or cyclobutylmethyl, or both R 4 groups, together with the nitrogen through which they are attached, form a heterocyclic ring of 4 to 6 ring atoms, where one carbon may be optionally replaced with N, O, S, or SO 2 , and where any carbon ring atom or additional N atom may be optionally substituted with C 1 -C 4 alkyl, F, or CF 3 ; R 5 is, independently at each occurrence, H, C 1 -C 4 alkyl, aryl substituted with 0-3 R 1 , or cyano; or when two R 5 are present, they form a carbocyclic ring of 3-7 carbons; R 6 is H, C 1 -C 4 alkyl, or cyano; R 7 is H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or aryl substituted with 0-3 R 1 ; R 8 is H, or C 1 -C 4 alkyl; R 9 is H, or C 1 -C 4 alkyl; R 10 is, independently at each occurrence, H, or C 1 -C 4 alkyl; or R 10 and R 4 together with the nitrogen to which R 4 is attached form a nitrogen-containing ring containing 3-6 carbon atoms; n is an integer from 0 to 4; x is an integer from 1 to 2; and R 11 is alkyl, alkoxy, halo, CF 3 , OCF 3 , hydroxy, alkanoyloxy, nitro, nitrile, alkenyl, alkynyl, alkylsulfoxide, alkylsulfone, alkylsulfonamide, or alkylamido; or two adjacent R 11 also represent methylenedioxy; wherein 1-3 carbon atoms in ring A may optionally be replaced with N.