Patent ID: 8771345

Claim:
A prosthesis for implantation at a native valve of a subject, the prosthesis comprising: a frame comprising: a distal fixation member configured to be positioned at least partially on a downstream side of the native valve, and shaped so as to define two or more leaflet engagement arms that are configured to apply a first force to tissue of the subject on a downstream side of the native valve, wherein the leaflet engagement arms are configured to contact a downstream side of a leaflet of the native valve without contacting commissures of the native valve upon implantation of the prosthesis; a proximal fixation member configured to be positioned at least partially on an upstream side of the native valve, at least a portion of the proximal fixation member being configured to contact an upstream side of the native valve upon implantation of the prosthesis, the proximal fixation member being configured to apply a second force to tissue of the subject on an upstream side of the native valve, wherein application of the first and second forces anchors the prosthesis to the native valve, wherein the leaflet engagement arms and the proximal fixation member are configured to capture leaflets of the native valve therebetween, upon implantation of the prosthesis; and a prosthetic valve positioned inside and coupled to the frame.