Patent ID: 7205297

Claim:
A compound of Formula I: wherein Z is O, NH or S, and m is 0 or 1; R 1 is (C2–6alkyl) a (C3–10cycloalkyl, C2–9heterocycloalkyl, C5–10aryl, or C4–9heteroaryl) b (C1–6alkyl) c , wherein a, b and c are independently 0 or 1, provided that at least one of a, b and c is 1 and if b is 0, then c is also 0, further providied that, when a is 1, the C2–6alkyl group is the point of attatchment and, when a is 0, the cyclic moity of R 1 is the point of attatchment, and wherein the hetrogroups include from 1 to 4 hetroatoms selected fron the group consisting of N, O and S, and the C and N atoms of the R 1 may optionally be substituted woth one or more substituents selected from the group consisting of: OH; halogen: thio; oxo; thioxo; carboxy; carboxamide; C1–7alkylcarbonyl; C1–7alkylcarbonyloxy C1–7alkylthiocarbonyl; C1–8alkyloxy; hydroxyC2–8alkyloxy; di-C1–8alkylphosphate ester C1–8alkylthio; hydroxyC2–8alkylthio; C1–8alkylsulfinyl; C1–8alkylsulfonyl; C1–5alkyloxyC1–5alkyl; C1–5alkylthioC1–5alkyl; C1–5alkylsulfinylC1–5alkyl; and C1–5alkylsulfonylC1–5alkyl; R 2 is selected from the group consisting of H, NH 2 and NH—CO—R 3 , where R 3 is H or C1–12 alkyl; and X is C6–10aryl optionally substituted with one or more substituents (y) selected from the group consisting of: OH; NO 2 NH 2 NH—CO—R 4 where R 4 is H, C1–12alkyl, aryl or (C1–6alkyl)aryl halogen; C1–6alkyl; hydroxyC1–6alkyl; oxoC2–7alkyl; C2–7alkenyl; C2–7alkynyl; C1–6alkoxy; CF 3 ; CF 3 C1–6alkyl; OCF 3 ; and CF 3 C1–6alkoxy; or a pharmaceutically acceptable salt thereof.