Patent ID: 8455432

Claim:
A method of lowering elevated or maintaining normal blood glucose levels in a subject in need thereof, consisting essentially of administering to said subject an effective amount of a compound of Formula (III) as a sole anti-diabetic or anti-hyperglycemic agent, wherein R 1 is selected from hydrogen, C 1-6 alkyl, C(O)C 1-6 alkyl and (CH 2 ) n phenyl, where n is 1, 2, 3, 4, 5 or 6 and phenyl may be unsubstituted or optionally substituted by one or more substituents independently selected from C 1-6 alkyl, halo, hydroxy, hydroxyC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxyC 1-6 alkoxy, haloC 1-6 alkyl, haloC 1-6 alkoxy, cyano, nitro, OC(O)C 1-6 alkyl, NH 2 , NHC 1-6 alkyl, NHC(O)C 1-6 alkyl and NC 1-6 alkylC 1-6 alkyl; and R 5 is selected from hydrogen, C 1-6 alkyl, C(O)C 1-6 alkyl, and (CH 2 ) n phenyl, where n is 1, 2, 3, 4, 5 or 6 and phenyl may be unsubstituted or substituted by one or more substituents independently selected from C 1-6 alkyl, halo, hydroxy, hydroxyC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxyC 1-6 alkoxy, haloC 1-6 alkyl, haloC 1-6 alkoxy, cyano, nitro, OC(O)C 1-6 alkyl, NH 2 , NHC 1-6 alkyl, NHC(O)C 1-6 alkyl and NC 1-6 alkylC 1-6 alkyl, or a pharmaceutically acceptable salt, or solvate thereof, wherein blood glucose homeostasis in the subject is regulated by said effective amount of the sole anti-diabetic or anti-hyperglycemic agent.