Patent ID: 8637452

Claim:
A water-soluble polypeptide comprising a modified α-helical domain, wherein the modified α-helical domain comprises an amino acid sequence in which one or more hydrophobic amino acid residues within an α-helical domain of a native membrane protein is replaced with one or more hydrophilic amino acid residues, wherein the native membrane protein is mOR103-15 or chemokine receptor CXCR4, and wherein the polypeptide comprises the amino acid sequence of (SEQ ID NO: 2) MERRNHTGRV SEFVLLGFPA PAPQRALQFF QSLQAYVQTL TENIQTITAIRNHPTLHKPM YYFLANMSFYL ETWYTTVTTP KMQAGYIGSE ENHGQLISFE ACMTQLYFFQ GLGCTECTLL AVMAYDRYVA TCHPLHYPVI VSSRQCVQMA AGSWAGGFGT SMTVKVYQISR LSYCGPNTIN HFFCDVSPLL NLSCTDMSTA ELTDFILAIF ILLGPLSVTG ASYMAITGAV MRIPSAAGRH KAFSTCASHL TTVITYYAAS IYTYARPKAL SAFDTNKLVS VLYAVIVPLL NPIIYCLRNQ EVKKALRRTL HLAQGDANT KKSSRDGGSS GTETSQVAPA; or (SEQ ID NO: 10) MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANYNKTFLPTIYSIIY QTGTVGNGIAMLVMGYQKKLRSMTDKYRLHLSTADLQFVTTLPYWATDA TANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRP RKLLAEKVVYVGVWTPAQLLTTPDYTFANVSEADDRYICDRFYPNDLWV VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTTTLI QAFFACWQPYYTGISIDSYILLEIIKQGCEFENTVHKWISTTEAQAFYH CCTNPTQYAYLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTE SESSSSFHS.