Patent ID: 8629241

Claim:
A compound having the formula (I): wherein each Xaa is independently selected from any L-alpha amino acid residues, 2 or 3 of which are favorable to alpha helix formation; or wherein each Xaa is independently selected from any D-alpha amino acid residues, 2 or 3 of which are favorable to alpha helix formation; wherein the amino acid residues that are favorable to alpha helix formation are selected from alanine, arginine, lysine, methionine, leucine, glutamic acid, glutamine, cysteine, isoleucine, phenylalanine, tryptophan, histidine and aspartic acid; wherein the compound has at least three (1,5) intramolecular hydrogen bonds; R 1 is selected from an N-terminal capping group; a non-peptidic group; a group that mimics an amino acid side chain; and an amino acid residue optionally capped by an N-terminal capping group, a non-peptidic group, or a group that mimics an amino acid side chain; R 2 is selected from a C-terminal capping group; a group that mimics an amino acid side chain; a group that activates the terminal carboxylic acid carbonyl group to nucleophilic substitution; and a peptide of 1, 2, 3, 4 or 5 amino acid residues optionally capped by a C-terminal capping group; a group that mimics an amino acid side chain; or a group which activates the terminal carboxylic acid carbonyl group to nucleophilic substitution; each R 9 and R 0 are independently selected from H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cylcoalkyl, C 5 -C 10 cycloalkenyl, —OH, —OC 1 -C 10 alkyl, —NH 2 , —NH(C 1 -C 10 alkyl), —N(C 1 -C 10 alkyl) 2 , C 6 -C 12 aryl, C 3 -C 10 heterocyclyl, C 5 -C 10 heteroaryl and halo; L is selected from —NH—C(O)—, —C(O)—NH—, —S—S—, —CH(OH)CH 2 —, CH 2 CH(OH)—, —CH═CH—, —CH 2 —CH 2 —, —NH—CH 2 — —C(O)—CH 2 —, —CH 2 —C(O)—, —S(O) t —NH—, —NH—S(O) t —, CH 2 —P(═O)(OH)— and —P(═O)(OH)—CH 2 —; m is 4; n is 1; and t is 0, 1 or 2.