Patent ID: 7084188

Claim:
A method of forming a surface modified medical device, the method comprising: providing a medical device comprising a copolymer prepared by polymerizing a monomer mixture comprising, (A) 20 to 80 weight % of at least one prepolymer selected from the group consisting of compounds having the following formula: YCO—CH═CHCOW(R 1 ) n (SiR 2 R 3 O) m (SiR 2 R 3 )(R 1 ) n WOCCH═CH—COY and CH 2 ═C(CH 2 COY)COW(R 1 ) n (SiR 2 R 3 O) m (SiR 2 R 3 )(R 1 ) n WOC(CH 2 COY)C═CH 2 wherein R 1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R 2 and R 3 are independently selected from the group consisting of alkyl groups, phenyl groups, alkyl groups substituted with halogen, phenyl groups substituted with halogen, alkyl groups containing ether linkages and phenyl groups containing ether linkages, W is O or NH, n is an integer between 1 and 10, m is an integer between 2 and 200, and Y is a residue having a reactive functional group selected from the group consisting of hydroxyl, carboxyl, oxazolone, epoxy and anhydride functional groups, and (B) 5 to 50 weight % of at least one copolymerizable device-forming monomer, contacting a surface of the device with a solution containing a surface modifying agent having functionality complementary to the functionalized silicone-containing copolymer; and subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a covalent bond between the functionalized silicone-containing copolymer and the surface modifying agent having functionality complementary to the functionalized silicone-containing copolymer while the surface modifying agent is in contact with the device surface to form a surface modified medical device.