Patent ID: 8173609

Claim:
Macrolide compound of formula I: wherein R1 is a residue —Y—X-Q; Y is S; X is a linear group consisting of hydrogen atoms and from 2 to 5 other additional atoms individually selected from the group consisting of C, N, O and S; Q is a residue —V-A1-L-A2-W or —NR6R7; V is a divalent group of formula wherein is a phenylene ring or a x-membered heteroaromatic ring containing from 2 to (x-1) carbon atoms with x being 5 or 6, and from 1 to 3 hetero nitrogen atoms, R8 and R9 are independently selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alko C 3 -C 7 cycloalkyloxy, C 3 -C 7 cycloalkyl-C 1 -C 4 alkoxy, halogen, halogen-substituted C 1 -C 4 alkyl groups, cyano, nitro, amino, C 1 -C 4 alkylamino, di(C 1 -C4)alkylamino, C 1 -C 4 alkylthio, mercapto, hydroxy, carbamoyl carboxy, and when both substituents R8 and R9 are located at adjacent carbon atoms of the ring these two substituents can be taken together with said adjacent carbon atoms to form a 5- or 6-membered aromatic or a x-membered heteroaromatic ring containing from 2 to (x-1) carbon atoms with x being 5 or 6, and from 1 to 3 hetero nitrogen atoms, wherein V can have from one to four substituents of the kind as defined for R8 and R9 and the free valences can be located either on one or on both rings of the group V; W is a group of formula wherein is a heteroaromatic ring containing from 2 to (x-1) carbon atoms with x being 5 or 6, and from 1 to 3 hetero nitrogen atoms, R10 and R11 are independently selected from the group consisting of hydrogen C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 3 -C 7 cycloalkyoxy, C 3 -C 7 cycloalkyl-C 1 -C 4 alkoxy, halogen, halogen-substituted C 1 -C 4 alkyl groups, cyano, nitro, amino, C 1 -C 4 alkylamino, di(C 1 -C4)alkylamino, C 1 -C 4 alkylthio, mercapto, hydroxy, carbamoyl and carboxyl, A1, A2 are independently of each other either absent or a C 1 -C 4 alkylene group; L is —NH—, —(CO)NH— or —NH(CO)—; R2, R3 taken together with their attached carbon atom form a C═O group; R4 is hydrogen or methyl; R6, R7 are independently selected from the group consisting of aryl; aralkyl; heterocyclyl and heterocyclylalkyl; and one of R6 and R7 can also be a group (C═O)W; and * indicates a chiral centre which is in the (R) or (S) form; except for the compound of formula I, wherein R1 is