Patent ID: 8343945

Claim:
A topical tetracycline antibiotic composition comprising a foamable pharmaceutical composition and a propellant, the foamable pharmaceutical composition comprising: a) about 0.1% to about 10% by weight of the foamable pharmaceutical composition of a tetracycline antibiotic; b) about 60% to about 95% by weight of the foamable pharmaceutical composition of: at least one oily emollient, wherein the oily emollient is selected from the group consisting of PPG-15 stearyl ether, octyldodecanol, diisopropyl adipate, isostearic acid, and cetearyl octanoate; at least one oil, wherein the oil is a liquid hydrocarbon-based oil; or a combination of at least one oily emollient and at least one oil; c) about 0.01% to about 15% by weight of the foamable pharmaceutical composition of at least one surfactant, wherein the surfactant is a fatty acid ester, having a C8-C24 saturated hydrocarbon chain; d) optionally 0.01% to about 10% by weight of the foamable pharmaceutical composition of at least one foam adjuvant, wherein the foam adjuvant is a fatty alcohol or a cocoglyceride; and wherein each component is tetracycline-compatible; wherein the composition comprises less than about 2% by weight of the foamable pharmaceutical composition of water; wherein at least 90% by mass of the tetracycline antibiotic is present in the foamable pharmaceutical composition when stored for 72 hours at 25° C. after mixing with the pharmaceutical composition; and wherein the weight ratio of the foamable pharmaceutical composition to the propellant is about 100:5 to about 100:35.