Patent ID: 8475822

Claim:
A method of coating a medical device, comprising preparing a composition which comprises at least one therapeutic compound and a molecule of formula IV: wherein the preparing step comprises reacting a molecule of formula I: with a molecule of formula II: adding the therapeutic compound to reactant of formula I or reactant of formula II or both prior to the reaction thereof, or adding the therapeutic compound to the reaction mixture of the reactants during the reaction thereof; wherein R 1 comprises a polymer, the polymer is in part polycarboxylic acid, cellulosic polymer, gelatin, polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyvinyl alcohol, polyethylene oxide, glycosaminoglycan, polysaccharide, polyester, silicone, polyurethane, polyorthoester, polyanhydride, polycarbonate, polypropylenes, polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxybutyrate valerate, polyacrylamide, polyether, and a mixture and copolymer thereof; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are alkyls or silanol-terminated alkyls; wherein n is an integer, 1≦n≦100; wherein the reaction is carried out at a temperature compatible with the therapeutic compound; and applying the composition to the surface of the medical device.