Patent ID: 7741332

Claim:
A compound of the formula: in which A is a member selected from the group consisting of substituted phenyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted isothiazolyl, substituted or unsubstituted isoxazolyl, substituted or unsubstituted 1,2,3,-oxadiazolyl, and six-membered substituted or unsubstituted heteroaryl, substituted or unsubstituted C 4 -C 8 cycloalkyl, and substituted or unsubstituted 5-8 membered heterocyclyl; X is a member selected from CO and CS; W is N; Z is a member selected from the group consisting of —CH 2 —, —CHF—, —CF 2 —, and —NR 4 (CR 4a R 4b ) s — wherein R 4 is a member selected from H and a substituted or unsubstituted C 1 -C 5 alkyl group; R 4a and R 4b are members independently selected from H, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted 5-7 membered heterocyclyl, and substituted or unsubstituted C 1 -C 8 alkyl; s is an integer from 1 to 3; Y is (CR 5 R 6 ) n , wherein n is an integer from 0-4; and R 5 and R 6 are members independently selected from H, F, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted 5-7 membered heterocyclyl, and substituted or unsubstituted C 1 -C 8 alkyl; R 1 is a member selected from substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted 5-7 membered heterocyclyl, and substituted or unsubstituted C 1 -C 8 alkyl; and R 2 is a member selected from the group consisting of CF 3 , substituted or unsubstituted C 1 -C 8 alkyl selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, isobutyl, sec-butyl, cyclohexyl, (cyclohexyl)methyl, cyclopropylmethyl, and homologs and isomers of n-pentyl, n-hexyl, n-heptyl, n-octyl; substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted 3-7-membered heterocyclyl, such that when X is C(O), A is a substituted phenyl forming a 1,3-benzodioxolyl ring; and Y—R 2 is unsubstituted acyclic alkyl, acyclic alkyl substituted with an amide or unsubstituted phenyl, then Z-R 1 is other than acyclic alkyl substituted with unsubstituted phenyl, and acyclic alkyl substituted with 4-phenyl- 1-halo.