Patent ID: 7625923

Claim:
A compound according to formula I: or a pharmaceutically acceptable salt thereon wherein R 1 is selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, arylalkyl, substituted arylalkyl, CO 2 R 4 , CONR 4 R 4 and CH 2 OR 4 ; R 2 is at each occurrence independently selected from the group consisting of H, alkyl, substituted alkyl, OR 3 , SR 3 , halo, NHR 3 , NHCOR 4 , NHCO 2R 4 , NHCONR 4 R 4 and NHSO 2 R 4 , with the provisos that at least one of R 2 must not be H; and one R 2 group attached to the carbon next to the bridgehead carbon is OH; R 3 is at each occurrence independently selected from the group consisting of H, alkyl, substituted alkyl, CHF 2 , CF 3 and COR 4 ; R 4 is at each occurrence independently selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; R 5 is at each occurrence independently selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, wherein at least one R 5 is hydrogen; or, alternatively, R 5 and R 5 taken together can form a double bond to O or S; X is O or S; Y is G; R 6 is selected from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, arylalkyl, substituted arylalkyl, CO 2 R 4 , CONR 4 R 4 and CN; G is selected from the group consisting of aryl, heterocyclo and heteroaryl, wherein said aryl, heterocyclo or heteroaryl is mono- or polycyclic, and is optionally substituted with one or more substituents selected from the group consisting of hydrogen, halo, CN, CF 3 , OR 4 , CO 2 R 4 , NR 4 R 4 , CONR 4 R 4 , CH 2 OR 4 , alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; and n is an integer of 1 or 2.