Patent ID: 6878748

Claim:
A fluorinated cycloalkyl-derivatized benzoylguanidine of formula I in which: X is oxygen, sulfur or NR6; wherein R6 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or (CH 2 ) k —CF 3 ; k is 0, 1, 2 or 3; m is zero, 1, 2 or 3; n is zero, 1, 2 or 3; p is zero, 1, 2, or 3; q is 1,2 or 3; r is zero, 1, 2 or 3; the total of m, n, p, q and r is 2-8; R1 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, F, Cl, —OR(7), —NR(8)R(9) or —C s F 2s+1 , wherein R(7), R(8) and R(9) are each, independently of one another, hydrogen, alkyl having 1, 2 or 3 carbon atoms or (CH 2 ) t —CF 3 ; s is 1, 2, 3 or 4; t is 0, 1, 2, 3 or 4; R2 is hydrogen, F, Cl, alkyl having 1, 2, 3 or 4 carbon atoms or CF 3 ; R3 is hydrogen, F, Cl, alkyl having 1, 2, 3 or 4 carbon atoms, CF 3 or SO u R10; u is zero, 1 or 2; R10 is alkyl having 1, 2, 3 or 4 carbon atoms or NR11R12; R11 and R12 are each, independently of one another, hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms; R4 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, F, Cl, —OR(13), —NR(14)R(15) or —C v F 2v+1 ; R(13), R(14) and R(15) are each, independently of one another, hydrogen, alkyl having 1, 2 or 3 carbon atoms or (CH 2 ) w —CF 3 ; v is 1, 2, 3 or 4; w is 0, 1, 2, 3, or 4; R5 is hydrogen or F; and the pharmacologically acceptable salts thereof.