Patent ID: 8835505

Claim:
A co-solvent sterile premixed pharmaceutical product stored in a non-PVC flexible plastic container, wherein said pharmaceutical product has a solution pH between 4.5 and 5.5 and comprises: a. 5 to 22.5 mg/mL methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol hydrochloride), b. a buffering agent to maintain a solution pH between 4.5 and 5.5, c. 0.1% to 3 w/v % of ethyl alcohol, and d. 0.1% to 3 w/v % of one of propylene glycol or glycerin; and wherein said pharmaceutical product is contained in a sealed container and heat-moist sterilized for a period of time sufficient to render the composition sterile.