Patent ID: 7700368

Claim:
A method for producing Δ 9 tetrahydrocannabivarin (Δ 9 THCV) crystals comprising: i) obtaining an ethanolic solution of a botanical drug substance from cannabis plant material, ii) passing the solution obtained in step i) through a column of activated charcoal, and collecting the eluate, iii) remove solvent from the eluate by rotary evaporation to give a Δ 9 THCV enriched fraction, iv) passing a solution of the resulting Δ 9 THCV enriched extract through a column packed with Sephadex LH20, eluting with 2:1 chloroform/dichloromethane, v) collecting Δ 9 THCV rich fractions and removing solvent by rotary evaporation, vi) re-dissolving the crude Δ 9 THCV prepared in step v) in methanol, removing insoluble residue by filtration and removing solvent from the filtrate by rotary evaporation, and vii) re-dissolving the crude Δ 9 THCV prepared in step vi) in pentane, removing insoluble residue by filtration and removing solvent from the filtrate by rotary evaporation to give said crystals of Δ 9 THCV.