Patent ID: 8765100

Claim:
A tablet comprising: a) fentanyl and/or at least one pharmaceutically acceptable salt thereof in a pharmaceutically effective amount for buccal mucosal administration in a human; b) at least one effervescent couple present in an amount ranging from about 5% by weight to about 80% by weight based on the weight of the tablet, said effervescent couple comprising at least one acid and at least one base, wherein said at least one base, which may be the same as or different from said at least one pH adjusting base, is present in an amount required for effervescence, wherein the at least one acid is selected from citric, tartaric, malic, fumaric, adipic and succinic acid, and the at least one base is selected from sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate and magnesium carbonate; and c) at least one pH adjusting base, selected from sodium carbonate, potassium carbonate, magnesium carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, and potassium dihydrogen phosphate, said pH adjusting base being present in an amount additional to that required for effervescence; and wherein said tablet further comprises at least one disintegration agent present in an amount up to about 20% by weight based on the weight of the tablet.