Patent ID: 8680265

Claim:
A process for the production of a compound of formula I wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH 2 ) n C 2 HB 9 H 10 or O(CH 2 ) n C 2 HB 10 H 10 wherein n is 0 or an integer from 1 to 20 and O(CH 2 ) n C 2 HB 9 H 10 is nido ortho-, meta- or para-carborane and O(CH 2 ) n C 2 HB 10 H 10 is ortho-, meta- or para-carborane, said process comprising the in situ generation of a compound of formula III according to a process comprising: a) combining a compound having the formula II with the acetate of M, to form a compound having the formula III in situ, and b) combining the in situ generated compound of formula III with a halogenating agent bromine in methanol to form a compound having the formula I.