Patent ID: 8063072

Claim:
A compound according to formula I wherein: X is CR 5 ; R 1 is A-1 optionally substituted by halogen, C 1-6 alkyl, C 1-3 haloalkyl, C 1-6 alkoxy: R 2 is hydrogen, cyano or hydroxyl; R 3 is CH═CHAr, [C(R 6 ) 2 ] n , naphthyl or C(═O)X 2 wherein Ar is phenyl and said phenyl or said naphthyl are optionally independently substituted with one to three substitutents selected from the group consisting of (a) hydroxy, (b) C 1-6 alkoxy, (c) C 1-6 alkyl, (d) C 1-10 hydroxyalkyl wherein one or two carbon atoms optionally can be replaced by oxygen provided that the replacement does not form a oxygen-oxygen bond, (e) C 1-3 alkoxy-C 1-6 alkyl, (f) halogen, (g) cyano, (h) C 1-6 alkoxycarbonyl, (i) C 1-6 alkylsulfonyl, (j) X 1 (CH 2 ) 1 — wherein X 1 is O, NR 6 or a bond, (k) C 1-3 acylamino-C 1-6 alkyl, (l) (CH 2 ) n NR a R b wherein n is zero to two, and (m) carboxyl; R a and R b are (i) independently in each occurrence (a) hydrogen, (b) C 1-6 alkyl, (c) C 1-6 alkylsulfonyl, (d) C 1-6 acyl, (e) C 1-6 haloalkylsulfonyl, (f) C 3-7 cycloalkylsulfonyl, (g) C 3-7 cycloalkyl-C 1-3 alkyl-sulfonyl, (h) C 1-6 alkoxy-C 1-6 alkylsulfonyl, (i) SO 2 NR 6 or (k) C 1-6 haloalkyl; X 2 is OH, C 1-6 alkoxy or NR c R d ; R c and R d are (i) independently in each occurrence hydrogen, C 1-6 alkyl or C 4-6 cycloalkyl or (ii) taken together with the nitrogen to which they are attached are a cyclic amine wherein the cycloalkyl or cyclic amine moiety is substituted by (CH 2 ) n NR a R b wherein n is zero to two; R 4 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, or CR 4a R 4b R 4c wherein (i) R 4a , R 4b and R 4c are independently selected from C 1-3 alkyl, C 1-2 alkoxy, C 1-3 fluoroalkyl, C 1-3 hydroxyalkyl, cyano or hydroxy; or (ii) when taken together, R 4a and R 4b together are C 2-4 alkylene and R 4c is hydrogen, C 1-3 alkyl, C 1-2 alkoxy, halogen, C 1-3 hydroxyalkyl, cyano or C 1-3 fluoroalkyl; R 5 is hydrogen, C 1-6 alkoxy, halogen or C 1-6 alkyl; R 6 is independently in each occurrence hydrogen or C 1-3 alkyl; or, a pharmaceutically acceptable salt thereof.