Patent ID: 7572801

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein: (a) X is selected from the group consisting of: (1) a single bond, (2) O, (3) N(R 9 )C(O), (4) N(R 9 )C(O)O, (5) OC(O)NR 9 , (6) N(R 9 )C(O)NR 10 , (7) N(R 9 )SO 2 , and (8) C(O)NR 9 if m is 1, 2 or 3; (b) Y is selected from the group consisting of: (1) a single bond, and (2) O if n is 1, 2, 3, 4, 5 or 6; (c) R 1 , R 2 and R 3 are independently from each other selected from the group consisting of: (1) hydrogen, (2) halogen, (3) lower-alkyl, (4) fluoro-lower-alkyl, (5) lower-alkoxy, (6) fluoro-lower-alkoxy, and (7) cycloalkyl; (d) R 4 , R 5 , R 6 and R 7 are independently from each other selected from the group consisting of: (1) hydrogen, (2) fluoro, (3) lower-alkyl, and (4) fluoro-lower-alkyl; or alternatively, R 4 and R 5 are bound together to form a ring together with the carbon atom to which they are attached wherein —R 4 —R 5 — is —(CH 2 ) 2-6 —, or R 6 and R 7 are bound together to form a ring together with the carbon atom to which they are attached wherein —R 6 —R 7 — is —(CH 2 ) 2-6 —; (e) R 8 is aryl or heteroaryl, wherein said aryl or heteroaryl is optionally substituted with 1 to 3 substituents independently from each other selected from the group consisting of: (1) halogen, (2) lower-alkyl, (3) lower-alkoxy, (4) fluoro-lower-alkyl, (5) fluoro-lower-alkoxy, (6) cycloalkyl, (7) fluoro-cycloalkyl, (8) cycloalkyl-oxy, (9) C(O)OH, (10) lower-alkoxy-C(O), (11) NH 2 C(O), (12) N(H,lower-alkyl)C(O), (13) N(lower-alkyl) 2 C(O), (14) OH, (15) lower-alkyl-C(O)O, (16) NH 2 , (17) N(H,lower-alkyl), (18) N(lower-alkyl) 2 , (19) lower-alkyl-C(O)NH, (20) lower-alkyl-C(O)N(lower-alkyl), (21) NH 2 SO 2 , (22) N(H,lower-alkyl)SO 2 , (23) N(lower-alkyl) 2 SO 2 , (24) lower-alkyl-SO 2 —NH, (25) lower-alkyl-SO 2 —N(lower-alkyl), (26) cyano, and (27) phenyl which is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy and fluoro-lower-alkyl; (f) R 9 and R 10 independently from each other are selected from the group consisting of: (1) hydrogen, (2) lower-alkyl, and (3) fluoro-lower-alkyl; and (g) m is 0, 1, 2 or 3; and n is 0, 1, 2, 3, 4, 5 or 6; wherein m+n is ≧1.