Patent ID: 8394795

Claim:
A compound selected from Formula I: and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein: R 1 and R 2 are independently selected from hydrogen, halogen, CN, C 1 -C 3 alkyl, and C 1 -C 3 alkoxy; R 3 is hydrogen, halogen, or C 1 -C 3 alkyl; R 4 is C 3 -C 5 cycloalkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, phenyl, a 5-6 membered heteroaryl, or NR g R h , wherein the cycloalkyl, alkyl, alkenyl, alkynyl, phenyl and heteroaryl are optionally substituted with OR c , halogen, phenyl, C 3 -C 4 cycloalkyl, or C 1 -C 4 alkyl optionally substituted with halogen; R 5 is: hydrogen, halogen, CN, NR c R d , OR e , SR f , phenyl optionally substituted with one to three R a groups, a 5-6 membered heteroaryl optionally substituted with C 1 -C 4 alkyl, a saturated or partially unsaturated C 3 -C 6 cycloalkyl optionally substituted with halogen or C 1 -C 4 alkyl, a saturated or partially unsaturated 4-6 membered heterocyclyl optionally substituted with C 1 -C 4 alkyl, C 2 -C 6 alkynyl optionally substituted with halogen, OR c , or NR c R d , C 2 -C 6 alkenyl optionally substituted with halogen, OR c , or NR c R d , or C 1 -C 6 alkyl optionally substituted with one to three R b groups; each R a is independently selected from halogen, CF 3 , C 1 -C 4 alkyl or —O(C 1 -C 4 alkyl), wherein the alkyl or alkoxy are optionally substituted with OH, NR c R d or a 5-6 membered heterocyclyl optionally substituted with C 1 -C 3 alkyl; each R b is independently selected from halogen, OH, OCH 3 , oxo, —NR c R d , or C 3 -C 6 cycloalkyl; each R c and R d are independently selected from hydrogen, phenyl, and C 1 -C 4 alkyl optionally substituted with oxo; R e is selected from a 4-6 membered heterocyclyl and C 1 -C 6 alkyl optionally substituted with halogen, OH, OCH 3 , C 3 -C 6 cycloalkyl or a 4-6 membered heterocyclyl; R f is C 1 -C 6 alkyl; and R g and R h are independently selected from hydrogen and C 1 -C 5 alkyl optionally substituted with halogen, or R g and R h together with the nitrogen to which they are attached form a 4 to 6 membered heterocyclic ring.