Patent ID: 8859553

Claim:
A compound of Formula VIII, or a pharmaceutically acceptable salt, hydrate, isomer, or solvate thereof: wherein, R 1 is selected from: R 2 is independently H, halogen, CN, NO 2 , CF 3 , OCF 3 , NH 2 , NR e R f , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, OCH 3 , COOCH 3 , or NHCOCH 2 CH 3 ; R 3 is R 4 is independently H, halogen, ON, NO 2 , CF 3 , OCF 3 , NH 2 , NR e R f , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, OCH 3 , COOCH 3 , or NHCOCH 2 CH 3 ; R 5 is independently H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, phenyl, or benzyl; R 6 is independently H, halogen, ON, NO 2 , CF 3 , OCF 3 , NH 2 , NR e R f , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, OCH 3 , COOCH 3 , or NHCOCH 2 CH 3 ; R 7 is independently H, C 1 -C 6 alkyl, or C 3 -C 6 cycloalkyl; R 8 is independently H, halogen, ON, NO 2 , CF 3 , NH 2 , NR e R f , C 1 -C 6 alkyl, or C 3 -C 6 cycloalkyl; R e and R f is independently C 1 -C 6 alkyl; m is 0, 1, or 2; n is 0, 1, or 2; w is 0, 1, or 2; s is 0, 1, or 2; u is 0, 1, or 2; and q is 1 or 2.