Patent ID: 7524883

Claim:
A compound having the structure (I): or pharmaceutically acceptable derivative thereof; wherein each occurrence of A, J, E, D and G is independently CR A , CR A R B , C═O, O, S, NR A , or N, wherein each occurrence of R A and R B is independently hydrogen, a protecting group, or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; A and J, J and D, D and E, and D and G are each independently linked by a single or double bond as valency permits; w, x, y and z are each independently 0, 1, 2, 3, 4, 5 or 6, but the sum of x, y and z is 2-6; R 1 , R 2 , R 3 and R 4 are each independently hydrogen, halogen, —CN, —OR C , —SR C , —NR C R D , —(C═O)R C or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, wherein each occurrence of R C and R D is independently hydrogen, a protecting group, or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, or R C and R D , taken together, form a heteroalicyclic or heteroaryl moiety; or wherein any two adjacent groups R 1 , R 2 , R 3 and R 4 , taken together, form an alicyclic or heteroalicyclic moiety, or an aryl or heteroaryl moiety; R 5 and R 6 are each independently an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety; and Q is an epoxycarbonyl moiety having the structure: wherein R Q1 is hydrogen, an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, an oxygen protecting group or a prodrug moiety.