Patent ID: 6919347

Claim:
A compound of formula wherein: A is A 1 or A 2 ; A 1 is R 4 R 5 N—C(O)—, A 2 is chosen from R 7 C(O)NH—, R 7 S(O) 2 NH—, R 4 NH—, and R 4 O—; Q is chosen from imidazolyl, methylimidazolyl, pyrrolyl, methylpyrrolyl, pyrazolyl, methylpyrazolyl, hydroxymethylimidazolyl, (dimethylaminomethyl)imidazolyl, furanyl, methylfuranyl, thienyl, oxazolyl, thiazolyl, pyridinyl, quinolinyl, 1-methylpyrimidin-2-onyl, phenyl, fluorophenyl, hydroxymethyl, tetrahydropyranyloxymethyl, imidazolylmethyl, pyrrolylmethyl, —CH═N—OCH 3 and W is chosen from H, Cl, F, R 8 , C 1 -C 4 -alkylaryl, —OR 8 , —SR 8 , —NR 9 R 10 and —NHC(O)R 11 , with the proviso that when Q is imidazolyl, W is not H, Cl, F or R 8 ; R 1 is chosen from alkyl, cycloalkyl, alkenyl, C 1 -C 3 -alkylcycloalkyl, heterocyclyl, C 1 -C 3 -alkylheterocyclyl, aryl, C 1 -C 3 -alkylaryl, heteroaryl, C 1 -C 3 -alkylheteroaryl, (C 1 -C 3 -alkyloxy)alkyl, (C 1 -C 3 -alkyloxy)cycloalkyl, (C 1 -C 3 -alkylthio)alkyl, (C 1 -C 3 -alkylthio)cycloalkyl and (C 1 -C 3 -alkylsulfonyl)alkyl; R 2 is H or C 1 -C 3 -alkyl, or R 1 and R 2 taken together form a 5- to 7-membered ring structure optionally containing O, S or NR 12 ; R 3 is H or C 1 -C 6 -alkyl, or, when n is zero, R 2 and R 3 taken together may form a 6-membered ring, which may be fused to a six-membered saturated or aromatic carbocycle; R 4 is chosen from H, aryl, heteroaryl, C 1 -C 4 -alkyl substituted with from one to three aryl or heteroaryl residues, wherein J 1 and J 2 are independently chosen from H, F, Cl, CN, NO 2 and CH 3 , and G is chosen from —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, —OCH 2 —, —CH 2 O—, —CH 2 CH 2 O—, —OCH 2 CH 2 —, —O—, —N(lower alkyl)-, —N(lower alkyl)CH 2 —, —CH 2 N(lower alkyl)-, —S—, —SO—, —SO 2 —, —CH 2 S—, —SCH 2 —, —CH 2 SO—, —SOCH 2 —, —CH 2 SO 2 —, and —SO 2 CH 2 —; R 5 is H or C 1 -C 3 -alkyl, with the proviso that both R 3 and R 5 cannot be alkyl; R 6 is aryl; R 7 is aryl or C 1 -C 3 -alkylaryl; R 8 is chosen from alkyl, aryl, heteroaryl, substituted alkyl, C 1 -C 4 -alkylaryl, C 1 -C 4 -alkylheterocyclyl and C 1 -C 4 -alkylheteroaryl; R 9 is chosen from H, alkyl, alkenyl, substituted alkyl, cycloalkyl, aryl, alkoxy, heteroaryl, fluoroalkyl, C 1 -C 4 -alkylcycloalkyl, (C 1 -C 4 -alkoxy)alkyl, (C 1 -C 4 -alkoxycarbonyl)alkyl, (C 1 -C 4 -alkylthio)alkyl, heterocyclyl, C 1 -C 4 -alkylheterocyclyl, C 1 -C 4 -alkylaryl, and C 1 -C 4 -alkylheteroaryl; R 10 is H or C 1 -C 3 -alkyl, or R 9 and R 10 taken together may form a 5- to 7-membered ring structure optionally containing O, S, SO, SO 2 or NR 12 , said ring optionally substituted with —OH, —CN, —COOH or —COOCH 3 ; R 11 is aryl; R 12 is chosen from H, C 1 -C 3 -alkyl, alkoxycarbonyl, methoxyacetyl and aryl; m is zero or one; and n is zero or one, with the proviso that when A is A 2 , m and n cannot both be zero.