Patent ID: 8202974

Claim:
A stabilized immune modulatory RNA (SIMRA) compound having the sequence: (a) 5′-UUG 1 CUG 1 AG 1 CUU-X-UUCG 1 AG 1 UCG 1 UU-5′ (5′-SEQ ID NO:1-3′-X-3′-SEQ ID NO:1-5′); (b) 5′-CUG 1 AG 1 AAG 1 CUU-X-UUCG 1 AAG 1 AG 1 UC-5′ (5′-SEQ ID NO:5-3′-X-3′-SEQ ID NO:5-5′); (c) 5′-CUG 1 ACG 1 AG 1 CUU-X-UUCG 1 AG 1 CAG 1 UC-5′ (5′-SEQ ID NO:6-3′-X-3′-SEQ ID NO:6-5′); (d) 5′-ACUUG 1 ACCUG 1 U-X-UG 1 UCCAG 1 UUCA-5′ (5′-SEQ ID NO:10-3′-X-3′-SEQ ID NO:10-5′); (e) 5′-ACUG 1 AG 1 AG 1 CUU-X-UUCG 1 AG 1 AG 1 UCA-5′ (5′-SEQ ID NO:15-3′-X-3′-SEQ ID NO:15-5′); (f) 5′-ACG 1 CUG 1 AG 1 CUU-X-UUCG 1 AG 1 UCG 1 CA-5′ (5′-SEQ ID NO:17-3′-X-3′-SEQ ID NO:17-5′); (g) 5′-AAUUG 1 ACG 1 CUU-X-UUCG 1 CAG 1 UUAA-5′ (5′-SEQ ID NO:18-3′-X-3′-SEQ ID NO:18-5′); (h) 5′-AAUUG 1 ACG 1 CUG 1 -X-G 1 UCG 1 CAG 1 UUAA-5′ (5′-SEQ ID NO:19-3′-X-3′-SEQ ID NO:19-5′); (i) 5′-AAG 1 UG 1 CG 1 ACUU-X-UUCAG 1 CG 1 UG 1 AA-5′ (5′-SEQ ID NO:20-3′-X-3′-SEQ ID NO:20-5′); (j) 5′-AAG 1 UG 1 ACG 1 CUU-X-UUCG 1 CAG 1 UG 1 AA-5′ (5′-SEQ ID NO:21-3′-X-3′-SEQ ID NO:21-5′); (k) 5′-AAG 1 UG 1 ACG 1 AUU-X-UUAG 1 CAG 1 UG 1 AA-5′ (5′-SEQ ID NO:22-3′-X-3′-SEQ ID NO:22-5′); (l) 5′-AACUUG 1 AG 1 CUU-X-UUCG 1 AG 1 UUCAA-5′ (5′-SEQ ID NO:23-3′-X-3′-SEQ ID NO:23-5′); (m) 5′-AACUG 1 CG 1 ACUU-X-UUCAG 1 CG 1 UCAA-5′ (5′-SEQ ID NO:24-3′-X-3′-SEQ ID NO:24-5′); (n) 5′-AACUG 1 ACG 1 CUU-X-UUCG 1 CAG 1 UCAA-5′ (5′-SEQ ID NO:25-3′-X-3′-SEQ ID NO:25-5′); (o) 5′-AACUG 1 ACG 1 CUG 1 -X-G 1 UCG 1 CAG 1 UCAA-5′ (5′-SEQ ID NO:26-3′-X-3′-SEQ ID NO:26-5′); (p) 5′-AACUG 1 AAG 1 CUU-X-UUCG 1 AAG 1 UCAA-5′ (5′-SEQ ID NO:28-3′-X-3′-SEQ ID NO:28-5′); (q) 5′-AACUG 1 AAG 1 CUG 1 -X-G 1 UCG 1 AAG 1 UCAA-5′ (5′-SEQ ID NO:29-3′-X-3′-SEQ ID NO:29-5′); or (r) 5′-AAUUG 1 AAG 1 CUG 1 -X-G 1 UCG 1 AAG 1 UUAA-5′ (5′-SEQ ID NO:31-3′-X-3′-SEQ ID NO:31-5′); wherein G 1 is 7-deaza-G and X is a glycerol linker, and wherein the compound selectively induces activity through TLR7.