Patent ID: 7678820

Claim:
A compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A is X is a single bond, —CH 2 —, —NR 3 —, —O—, —S—, —S(═O)—, or —S(═O) 2 —; R 1 is halogen, aryl, heteroaryl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 3 -C 8 )heterocycloalkyl, or optionally substituted (C 1 -C 6 )alkyl or optionally substituted (C 2 -C 6 )alkenyl, each of which may contain halogen, —CONH 2 , aryl, or (C 3 -C 8 )cycloalkyl as a substitutent; R 2 is —CN, —O—(C 1 -C 6 )alkyl, —C(═O)H or halogen, or optionally substituted (C 1 -C 6 )alkyl which may be substituted with halogen or —OH wherein when —X— is a single bond, R 1 and R 2 may in combination form a 5-membered ring and may further contain (C 1 -C 6 )alkyl as an optional substituent; R 3 is —H, wherein R 3 may form morpholino, 1-pyrrolidinyl or 3,4-dehydropiperidin-1-yl, together with R 1 and nitrogen; R 4 is wherein any one of the bonds from the R 4 ring is bound to the oxadiazole ring; R 5 is —H, R 0 —(C 1 -C 6 )alkyl-, R 0 —(C 1 -C 6 )alkyl-O—, R 0 —(C 1 -C 6 )alkyl-C(═O)—, R 0 —(C 1 -C 6 )alkyl-S(═O) 2 —, R 0 —O—(C 1 -C 6 )alkyl-, R 0 —C(═O)—(C 1 -C 6 )alkyl-, R 0 —S(═O) 2 —(C 1 -C 6 )alkyl-, (C 2 -C 6 )alkenyl-, —C(═O)H, —OR X , —S(═O) 2 R X , halogen, ═O, —NR X R Y , or —C(═O)NR X R Y , wherein R 0 —(C 1 -C 6 )alkyl-means (C 1 -C 6 )alkyl which may be substituted with at least one group each selected from R 0 , wherein R 0 —CN, —C(═O)NR X R Y , —NHR X , —SR X , —S(═O) 2 R X or —OR X ; and R X and R Y may be the same or different and are —H, or (C 1 -C 6 )alkyl which may be optionally substituted with —OH, —NH 2 (which may be protected with a protecting group) or heteroaryl, wherein R X may form (C 3 -C 8 )heterocycloalkyl, together with R Y and nitrogen.