Patent ID: 7968683

Claim:
A crystalline complex comprising Factor IXa bound to a peptide and a compound, wherein said Factor IXa comprises a polypeptide selected from the group consisting of SEQ ID NO: 14 or SEQ ID NO: 18, said peptide comprises SEQ ID NO: 13 and said compound is selected from the group consisting of: wherein said crystal complexes form in the following crystalline forms: (i) when said complex is formed with compound (a) said crystal forms in space group P2 1 2 1 2 1 having unit cell dimensions a=48.1 Å, b=69.8 Å, c=92.1 Å and α=β=γ=90° or space group P4 3 2 1 2 having unit cell dimensions a=100.4 Å, b=100.4 Å, c=97.3 Å and α=β=γ=90°; (ii) when said complex is formed with compound (b) said crystal forms in space group P4 3 2 1 2 having unit cell dimensions a=100.6 Å, b=100.6 Å, c=98.1 Å and α=β=γ=90°; (iii) when said complex is formed with compound (c) said crystal forms in space group P4 3 2 1 2 having unit cell dimensions a=99.2 Å, b=99.2 Å, c=97.3 Å and α=β=γ=90°; and (iv) when said complex is formed with compound (d) said crystal forms in space group P4 3 2 1 2 having unit cell dimensions a=100.5 Å, b=100.5 Å, c=98.4 Å and α=β=γ=90°.