Patent ID: 7994114

Claim:
A method of increasing the number of hematopoietic cells circulating in the blood of a subject comprising administering an effective amount of a composition comprising an SDF-1 mimetic to the subject, wherein the SDF-1 mimetic consists of the following structure: R N —HN-Xaa 3 -Pro-Val-Ser-Leu-Ser-Tyr-Arg-Xaa 1 -Pro-Xaa 2 -Arg-Phe-Phe-[linker]-Leu-Lys-Trp-IIe-Gln-Glu-Tyr-Leu-Glu-Lys-Ala-Leu-Asn-Rc (SEQ ID NO:10); wherein, R N is an N-terminal modifier that comprises a component selected from a group consisting of hydrogen, poly(ethylene glycol), a biochemical label, a radiolabel, an acyl group, an acetyl group, and an N-terminal modifier capable of reducing the ability of the SDF-1 mimetic to act as a substrate for aminopeptidases; R C is a C-terminal modifier that comprises a component selected from a group consisting of a hydroxyl group, poly(ethylene glycol), a biochemical label, a radiolabel, an amido group, and a C-terminal modifier capable of reducing the ability of the SDF-1 mimetic to act as a substrate for carboxypeptidases; Xaa 1 is Ala and Xaa 2 is Phe; Xaa 3 is Lys or des-Lys; and, the linker is Gly-Gly-Gly-Gly (residues 15-18 of SEQ ID NO:810) or —(CH 2 ) n —, wherein n is an integer ranging from 9 to 14.