Patent ID: 7985749

Claim:
A compound of Formula I in which R 1 is R 6 and R 7 are independently chosen from hydrogen, C 1-6 alkyl, cyano-C 0-6 alkyl, C 3-12 cycloalkylC 0-4 alkyl and C 6-10 arylC 0-4 alkyl; or R 6 and R 7 together with the carbon atom to which R 6 and R 7 are attached form C 3-8 heterocycloalkyl or C 3-12 cycloalkyl; wherein any alkyl of R 6 and R 7 can optionally have a methylene replaced with an atom or group chosen from O and S(O) 0-2 ; wherein any aryl, heterocycloalkyl or cycloalkyl of R 6 , R 7 or formed by the combination of R 6 and R 7 can be optionally substituted with 1 to 3 radicals independently selected from the group consisting of halo, hydroxy, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XC(O)OR 10 , —X(S(O) 0-2 R 10 , —XNRS(O) 0-2 R 10 and —XS(O) 0-2 NR 10 R 10 ; wherein X is a bond or C 1-4 alkylene; and R 10 is independently chosen from hydrogen and C 1-6 alkyl; R 8 is C 5-10 heterarylC 0-4 alkyl; wherein any heteraryl of R 8 can be optionally substituted by 1 to 3 radicals independently chosen from halo, hydroxy, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 6-10 aryl, C 5-10 heteraryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl; and R 2 is chosen from hydrogen and C 1-6 alkyl; R 3 and R 4 are independently chosen from hydrogen, C 1-6 alkyl, C 3-12 cycloalkylC 0-4 alkyl and C 6-10 arylC 0-4 alkyl; wherein any alkyl of R 3 and R 4 can optionally have a methylene replaced with an atom or group chosen from O and S(O) 0-2 ; wherein any aryl or cycloalkyl of R 3 and R 4 can optionally be substituted with 1 to 3 radicals independently chosen from halo, hydroxy, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 5 is C 3-8 heterocycloalkyl; optionally substituted with 1 to 3 radicals independently selected from the group consisting of halo, hydroxy, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XC(O)OR 10 , —X(S(O) 0-2 R 10 , —XNR 10 S(O) 0-2 R 10 and —XS(O) 0-2 NR 10 R 10 ; wherein X is a bond or C 1-4 alkylene; and R 10 is independently chosen from hydrogen and C 1-6 alkyl; or a pharmaceutically acceptable salt, hydrate, solvate, isomer or prodrug thereof.