Patent ID: 7354922

Claim:
A compound of Formula (I): or a pharmaceutically acceptable salt, thereof, wherein: Ar 1 and Ar 2 are each independently selected from the group consisting of aryl substituted with 0 to 3 substituents R 6 and heteroaryl substituted with 0 to 3 substituents R 6 ; X 1 is â€”Oâ€”; X 2 is â€”N(R 8 )â€”; X 3 is â€”C(O)â€”; X 4 is â€”C(R 9 ) 2 â€”; n1 is an integer of from 0 to 4; R 1 is selected from the group consisting of H, â€”OH, alkyl, alkyl substituted with one or more hydroxyl groups, â€”O-alkyl, â€”O-alkyl-cycloalkyl, heteroaryl or aryl substituted with 0 to 3 substituents R 6 , â€”N(R 7 ) 2 , â€”N(R 11 )C(O)R 12 , heterocyclyl substituted with 0 to 3 substituents R 13 , â€”N(R 11 )C(O)N(R 14 ) 2 , â€”OC(O)N(R 14 ) 2 , â€”C(O)N(R 14 ) 2 , â€”C(O)R 12 , â€”OC(O)R 12 , â€”C(O)OR 15 , â€”CN, â€”CH 2 N 3 , â€”O-alkyl-aryl, â€”Oâ€”Nâ•C(R 12 ) 2 , â€”Sâ€”R 12 , â€”S(O)â€”R 12 , â€”S(O 2 )â€”R 12 , and N(R 11 )S(O 2 )â€”R 12 ; or when X 2 is â€”N(R 8 )â€”, R 1 and R 8 together can form a group X 5 as shown in Formula (IA): wherein X 5 is selected from the group consisting of â€”C(O)â€”, â€”(CH 2 ) n2 â€”Oâ€”, â€”(CH 2 ) n2 â€”, â€”(CH 2 ) n2 â€”C(O)â€”N(R 13 )â€”, â€”(CH 2 ) n2 â€”N(R 13 )â€”, and â€”C(O)â€”N(R 13 )â€”C(O)â€”; n2 is an integer of from 1 to 3; with the proviso that: (a) when X 5 is â€”C(O)â€”, n1 is 2 or 3; (b) when X 5 is â€”(CH 2 ) n2 â€”Oâ€”, n2 is 2 or 3; and (c) when X 5 is â€”(CH 2 ) n2 â€”, n1 is 2 or 3; R 2 , R 3 , R 4 , and R 5 are each independently selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, heterocyclyl substituted with 0 to 3 substituents R 13 , and aryl or heteroaryl substituted with 0 to 3 substituents R 6 ; each R 6 is independently selected from the group consisting of halogen, alkyl, â€”O-alkyl, haloalkyl, â€”O-haloalkyl, â€”CN, â€”OH, unsubstituted heteroaryl, and heteroaryl substituted with at least one alkyl or haloalkyl; R 7 is selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, heterocyclyl substituted with 0 to 3 substituents R 13 , aryl substituted with 0 to 3 substituents R 6 , -alkyl-aryl wherein the aryl moiety is substituted with 0 to 3 substituents R 6 , and heteroaryl substituted with 0 to 3 substituents R 6 ; R 8 is selected from the group consisting of H, alkyl, -alkyl-cycloalkyl, â€”C(O)N(R 14 ) 2 , â€”C(O)R 12 , and aryl or heteroaryl substituted with 0 to 3 substituents R 6 ; each R 9 is independently selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl; R 10 is alkyl or aryl.