Patent ID: 7537895

Claim:
A method of surveying all chromosomes in a human genome for the presence of a copy number variation in one or more unique DNA sequence(s), said method comprising: (a) labeling DNA comprising unique sequences from each chromosome from a sample with a label; (b) contacting the labeled DNA with a plurality of target nucleic acids comprising unique sequences from each chromosome under conditions that permit non-saturating hybridization of target nucleic acids, wherein either the labeled DNA or the target nucleic acids, or both, have been treated so as to block or remove repetitive sequences, if initially present, without blocking or removing unique sequences; and (c) comparing the intensities of the signals from the labeled DNA hybridized to each target nucleic acid to determine the copy number of at least one unique sequence in the hybridized labeled DNA relative to the copy numbers of one or more different unique sequences in the hybridized labeled DNA.