Patent ID: 8853392

Claim:
A compound having a structure represented by a formula: wherein N, R 1 , and R 2 together form an optionally substituted heterocyclic ring having from two to seven carbons; wherein both of Y 1 and Y 2 are carbon; wherein R represents four substituents independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, thiol, or an organic radical comprising 1 to 12 carbon atoms; wherein all of Z 1 , Z 2 , and Z 3 are carbon; and wherein R 4 represents five substituents independently selected from hydrogen, halogen, and cyano, wherein at least one of R 4 is halogen selected from F and Cl; or a pharmaceutically acceptable salt or N-oxide thereof, wherein the compound exhibits potentiation of mGluR5 response to glutamate as an increase in response to non-maximal concentrations of glutamate in human embryonic kidney cells transfected with rat mGluR5 in the presence of the compound, compared to the response to glutamate in the absence of the compound.