Patent ID: 8916694

Claim:
An antisense compound 15 to 30 nucleobases in length which specifically hybridizes with an allelic variant of a nucleic acid of SEQ ID NO: 1 encoding human apolipoprotein B, wherein said compound inhibits the expression of apolipoprotein B mRNA by at least 10% and wherein said compound is targeted to a region that includes at least one nucleobase selected from the group consisting of: (a) C at position 27751 of SEQ ID NO: 1; (b) G at position 27685 of SEQ ID NO: 1; (c) G at position 27683 of SEQ ID NO: 1; (d) G at position 27679 of SEQ ID NO: 1; (e) A at position 27634 of SEQ ID NO: 1; (f) T/U at position 27627 of SEQ ID NO: 1; and (g) G at position 27618 of SEQ ID NO: 1, wherein G is guanine, C is cytosine, T is thymine, U is uracil, and A is adenine; and wherein said antisense compound comprises a complementary nucleobase at said position.