Patent ID: 7906482

Claim:
A method of treating obesity, the method comprising administering to a subject a compound comprising a PYY peptide or a functional derivative thereof comprising a peptide of the formula: (SEQ ID NO: 1) X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 -X 14 - X 15 -X 16 -X 17 -X 18 -X 19 -X 20 -X 21 -X 22 -X 23 -X 24 -X 25 -X 26 - X 27 -X 28 -X 29 -X 30 -X 31 -X 32 -X 33 -X 34 -X 35 -X 36 -A wherein X 1 is absent, tyr or ala; X 2 is absent or pro; X 3 is absent, lys or an analog thereof, ile, leu, or ala; X 4 is absent, lys or an analog thereof, or glu; X 5 is absent or pro; X 6 is absent, glu, val or asp; X 7 is absent, ala, tyr or asn; X 8 is absent or pro; X 9 is absent or gly; X 10 is absent, glu or asp; X 11 is absent, asp or asn; X 12 is absent, lys or an analog thereof, or ala; X 13 is absent, lys or an analog thereof, ser, thr, or pro; X 14 is absent, lys or an analog thereof, ala, or pro; X 15 is absent, lys or an analog thereof, or glu; X 16 is absent, glu, gln or asp; X 17 is absent, leu or met; X 18 is absent, lys or an analog thereof, ser, ala, or asn; X 19 is absent, arg or gln; X 20 is absent or tyr; X 21 is absent, tyr or ala; X 22 is ala, ser or lys; X 23 is ser, asp or ala; X 24 is leu; X 25 is arg or lys; X 26 is his, arg or lys; X 27 is tyr; X 28 is leu or ile; X 29 is asn; X 30 is leu or met; X 31 is val, leu or ile; X 32 is thr; X 33 is arg or lys; X 34 is gln or pro; X 35 is arg or lys; X 36 is absent, tyr or a derivative thereof; and A is absent, lys or a derivative thereof, which is coupled to a reactive group, wherein said reactive group is a Michael acceptor, a succinimidyl-containing group, a maleimido-containing group or an electrophilic thiol acceptor, said reactive group being capable of reacting with an amino group, a hydroxyl group or a thiol group on a blood component so as to form a stable covalent bond therewith, thereby substantially preventing said PYY peptide or functional derivative thereof from crossing the blood brain barrier.