Patent ID: 7329683

Claim:
A compound of structural formula Ia wherein: R 1 is adamantyl, unsubstituted or substituted with one to five substituents independently selected from halogen, OCH 3 , OCF 3 , CH 3 , CF 3 , and phenyl, wherein said phenyl is unsubstituted or substituted with one to three halogens; X is selected from the group consisting of CH 2 and a single bond; W and Z are single bonds; and R 4 is a C 3-8 alkylene group, optionally containing one heteroatom selected from O and NR b between two adjacent carbon atoms of said C 3-8 alkylene group, optionally containing one to two carbon-carbon double bonds when R 4 is a C 3-8 alkylene group, and optionally also comprising a carbon-carbon single bond connecting two non-adjacent carbon atoms of said C 3-8 alkylene group, or a C 4-8 cycloalkyl group; wherein R b is selected from the group consisting of hydrogen and C 1-6 alkyl, unsubstituted or substituted with one to six substituents independently selected from zero to five fluorines and zero to one phenyl, said phenyl being unsubstituted or substituted with one to three substituents independently selected from halogen, CH 3 , CF 3 , OCH 3 , and OCF 3 ; wherein R 4 is unsubstituted or substituted with one to five R c substituents, wherein each R c is independently selected from halogen, OH, OCH 3 , OCF 3 , C 1-6 alkyl, C 2-6 alkenyl, phenyl, biphenyl, C 3-8 cycloalkyl, C 1-6 alkyloxycarbonyl, an epoxide group bridging 2 adjacent carbons, and 1,3-dioxolanyl geminally disubstituted onto one carbon of R 4 , wherein each C 1-6 alkyl and C 2-6 alkenyl is unsubstituted or substituted with one to five substituents independently selected from zero to three halogens and zero to two groups selected from phenyl, C 1-6 alkyloxycarbonyl, 1,3-dioxolanyl geminally disubstituted onto one carbon, and CN, and wherein each phenyl, biphenyl, and C 3-8 cycloalkyl, either as R c or as a substituent on R c , is unsubstituted or substituted with one to three groups independently selected from halogen, CH 3 , CF 3 , OCH 3 , and OCF 3 ; wherein R 4 optionally has a fused phenyl ring, a benzodioxinyl ring, or a dihydrobenzodioxinyl ring, said phenyl ring, benzodioxinyl ring, and dihydrobenzodioxinyl ring being unsubstituted or substituted with one to three substituents independently selected from halogen, CH 3 , CF 3 , OCH 3 , and OCF 3 ; and wherein R 4 , including said optional fused phenyl ring, benzodioxinyl ring, or dihydrobenzodioxinyl ring and including all substituents on R 4 and said fused phenyl ring, benzodioxinyl ring, or dihydrobenzodioxinyl ring, has no more than 20 carbon atoms.