Patent ID: 7514240

Claim:
A crystal of a complex of epidermal growth factor (EGF) comprising: the amino acid sequence of SEQ ID NO:2 and epidermal growth factor receptor (EGFR) having amino acids 1-619 of SEQ ID NO:1 capable of diffracting X-ray at a resolution of 3.3 Å, wherein the crystal has the following characteristics (A), (B), and (C): (A) EGF binds to EGFR at a 1:1 ratio; (B) the EGF-bound EGFRs form a dimer; and (C) the crystal has the space group P3 1 21, the unit cell parameters: a=220.2±1.5 Å, b=220.2±1.5 Å, and c=113.1±1.5 Å, and the bond angles: α=90°, β=90°, and γ=120°.