Patent ID: 7858666

Claim:
A compound which directly inhibits IRE-1α activity in vitro and is represented by structural formula (B): or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, phenyl or an optionally benzofused five- or six-membered heterocycle, wherein the phenyl or the optionally benzofused five- or six-membered heterocycle is optionally substituted with —CH 3 OH, —CHO, —OCH 3 , halogen, —OH, —CH 3 , R 2 is phenyl or an optionally benzofused five- or six-membered heterocycle, wherein the phenyl or the optionally benzofused five- or six-membered heterocycle is optionally substituted with —CH 3 OH, —CHO, —OCH 3 , halogen, —OH, —CH 3 , R 3 is hydrogen, halogen, —NO 2 , C 1 -C 3 linear or branched alkyl, C 1 -C 3 linear or branched alkoxy, C 1 -C 3 linear or branched hydroxyl alkyl, and R 4 is hydrogen,