Patent ID: 8889847

Claim:
An isolated polynucleotide encoding a humanized antibody that binds to STEAP-1, wherein the antibody comprises (a) a heavy chain variable domain comprising: (1) an HC-FR1 comprising the amino acid sequence of SEQ ID NO:25; (2) an HVR-H1 comprising the amino acid sequence of SEQ ID NO:14; (3) an HC-FR2 comprising the amino acid sequence of SEQ ID NO:22; (4) an HVR-H2 comprising the amino acid sequence of SEQ ID NO:15; (5) an HC-FR3 comprising the amino acid sequence of SEQ ID NO:138; (6) an HVR-H3 comprising the amino acid sequence of SEQ ID NO:16; and (7) an HC-FR4 comprising the amino acid sequence of SEQ ID NO:24; and (b) a light chain variable domain comprising: (1) a LC-FR1 comprising the amino acid sequence of SEQ ID NO:17; (2) an HVR-L1 comprising the amino acid sequence of SEQ ID NO:11; (3) a LC-FR2 comprising the amino acid sequence of SEQ ID NO:18; (4) an HVR-L2 comprising the amino acid sequence of SEQ ID NO:12; (5) a LC-FR3 comprising the amino acid sequence of SEQ ID NO:19; (6) an HVR-L3 comprising the amino acid sequence of SEQ ID NO:13; and (7) a LC-FR4 comprising the amino acid sequence of SEQ ID NO:20.