Patent ID: 7668662

Claim:
A method of establishing a patient-specific therapeutic dose for administration of an 131 I-labeled anti-B1 antibody radiopharmaceutical to a patient, the method comprising: determining a maximum tolerated dose for the radiopharmaceutical; determining a desired total body dose (TBD) of the radiopharmaceutical for the patient; administering to the patient a trace dose of a radiopharmaceutical or an analog of the radiopharmaceutical; determining a clearance profile for the radiopharmaceutical or a radiopharmaceutical analog; determining that the patient's mass is higher than the patient's maximum effective mass (MEM); determining the activity hours (AH) for the radiopharmaceutical or radiopharmaceutical analog with the following equation (Equation I): AH = TBD × ( MEM ) [ ∑ elec Δ elect + ∑ phot Δ phot ⁢ ⁢ ϕ phot TB ] ⁢ ⁢ where ⁢ [ ∑ elec Δ elect + ∑ phot Δ phot ⁢ ⁢ ϕ phot TB ] ( Equation ⁢ ⁢ I ) in Equation 1 represents the sum of electron energy and photon energy deposited in the total body of the patient by the radiopharmaceutical or radiopharmaceutical analog and said determining activity hours uses the patient's maximum effective mass (MEM); determining residence time of said administered trace dose of the radiopharmaceutical or the radiopharmaceutical analog in the whole body of the patient, the residence time being correlated to the clearance profile; and establishing the patient-specific dose of the radiopharmaceutical for the patient by solving for therapeutic dose in the following equation: therapeutic dose=Activity Hours/Residence time×desired total body dose/maximum tolerated dose.