Patent ID: 7622465

Claim:
A method of inhibiting TNFα expression, IL-1β expression, or iNOS expression in a subject in need thereof, comprising administering to the subject an effective amount of a compound of the following formula: wherein X is CH 2 ; Y is NR 1 R 2 or OCONR 1 R 2 , or X is C(O) and Y is NR 1 R 2 ; in which R 1 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl; and R 2 is H, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl, or R 1 , R 2 , and N to which they are attached, taken together, form a saturated or unsaturated 3-8 membered ring, optionally substituted with R 1 ′, OR 2 ′, NR 2 ′R 3 ′, SR 2 ′, C(O)R 2 ′, CO 2 R 2 ′, C(O)NR 2 ′R 3 ′, R 1 ′ being alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl, and each of R 2 ′ and R 3 ′, independently, being H, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl; and Z is a bond; or a pharmaceutically acceptably salt thereof.