Patent ID: 8193379

Claim:
A method for synthesizing a hydrohalide salt of 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of Formula A: in which X represents a halogen atom selected form the group consisting of chlorine, bromine and iodine, comprising the following successive stages: i) reaction, in a mixture of acid, water and organic solvent, at a temperature greater than ambient temperature, of thiourea with 4β-halogenoacetamido-4′-demethyl-4-desoxypodophyllotoxin of Formula 3: in which X represents a halogen atom selected form the group consisting of chlorine, bromine and iodine; and ii) recovery of the hydrohalide salt of 4β-amino-4′-demethyl-4-desoxypodophyllotoxin.