Patent ID: 7915300

Claim:
A compound of the formula II wherein one of R 1 and R 2 is halo and the other is H or halo; R 3 is C 1 -C 5 straight or branched chain, optionally fluorinated, alkyl; R 4 is H; or R 3 together with R 4 defines a spiro-C 5 -C 7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl; or optionally bridged with a methylene group; or a C 4 -C 6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(═O) 2 ; R 5 is independently selected from H or methyl; E is —C(═O)—, —S(═O) m —, —NR 5 S(═O) m —, —NR 5 C(═O)—, —OC(═O)—, R 6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or heterocycle wherein the or each ring has 4, 5 or 6 ring atoms and 0 to 3 hetero atoms selected from S, O and N and wherein the optional substituents comprise 1 to 3 members selected from R 7 ; R 7 is independently selected from halo, oxo, nitrile, nitro, C 1 -C 4 alkyl, —X—NRbR 9 , —NRb—X′—R 9 , NH 2 CO—, —X—R 9 , —X—O—R 9 , —O—X′—R 9 , —X—C(═O)R 9 , —X—(C═O)NRaR 9 , —X—NRbC(═O)R 9 , —X—NHSO m R 9 , —X—S(═O) m R 9 , —X—C(═O)OR 9 , —X—NRbC(═O)OR 9 ; R 9 is independently H, C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl, indolinyl, pyranyl, thiopyranyl, furanyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl, indolyl, phenyl, any of which is optionally substituted with R 10 ; R 10 is independently selected from hydroxy, —X—R 9 ′, —X—NRbR 9 ′, —NRb—X′—R 9 ′, nitro, cyano, carboxy, oxo, C 1 -C 4 -alkoxy, C 1 -C 4 alkanoyl, carbamoyl; R 9 ′ is independently H, C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl, indolinyl, pyranyl, thiopyranyl, furanyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl, indolyl, phenyl, any of which is optionally substituted with R 10 ′; R 10 ′ is independently selected from hydroxy, nitro, cyano, carboxy, oxo, C 1 -C 4 alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 alkanoyl, carbamoyl; or, where R 6 is a monocyclic group substituted directly or via methylene by an aryl or a 5 or 6 membered hetereoaryl moiety substituted by R 9 ′ which is a morpholinyl, piperidinyl or piperazinyl group, then R 10 ′ can additionally be fluoro, difluoro, or C 1 -C 3 alkyloxyC 1 -C 3 alkyl-; or, where R 6 is phenyl substituted by thiazol-4-yl, 5-methylthiazol-4-yl or thien-2-yl, any of which is substituted by morpholinylmethyl-, piperidinylmethyl-, piperazinylmethyl-, then R 10 ′ may additionally be fluoro, difluoro or C 1 -C 3 alkyl-O—C 1 -C 3 alkyl-; X is independently a bond or C 1 -C 4 alkylenyl; X′ is independently C 1 -C 4 alkylenyl; Ra is independently H, C 1 -C 4 alkyl or CH 3 C(═O); Rb is independently H, or C 1 -C 4 alkyl m is independently 0, 1 or 2; or a pharmaceutically acceptable salt thereof.