Patent ID: 7402304

Claim:
A method of treating a condition which is responsive to treatment with G-CSF comprised of administering an effective amount of a composition comprising a human Granulocyte Colony Stimulating Factor (G-CSF) analog polypeptide which comprises an amino acid substitution in the sequence of SEQ ID NO: 2 selected from the group consisting of: a) a substitution of aspartic acid with histidine at position number 109, [His109]G-CSF; b) a substitution of aspartic acid with histidine at position number 112, [His112]G-CSF; c) a substitution of glutamine with histidine at position number 119, [His119]G-CSF; d) any of the said analogs of subparts (a-c) optionally including an N-terminal methionyl residue; and e) any of(a)-(d) derivatized with one or more water soluble polymers to a patient in need thereof.