Patent ID: 7067517

Claim:
A method of inhibiting the lipolytic activity of hormone-sensitive lipase against triacylglycerols, diacylglycerols, cholesterol acyl esters or steroid acyl esters, comprising: administering to a subject in need of such treatment a compound of formula I wherein R 1 is selected from hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl and C 3-10 -cycloalkyl, each of which is optionally substituted with one or more substituents independently selected from hydroxy, sulfanyl, oxo, halogen, amino, cyano and nitro; and R 2 is selected from C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 -heterocyclyl and C 3-10 -cycloalkyl, each of which is optionally substituted with one or more substituents independently selected from hydroxy, sulfanyl, sulfo, oxo, halogen, amino, cyano, nitro, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 -heterocyclyl and C 3-10 -cycloalkyl, wherein each of hydroxy, sulfanyl, sulfo, amino, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 heterocyclyl and C 3-10 -cycloalkyl is optionally substituted with one or more substituents independently selected from hydroxy, sulfanyl, sulfo, oxo, halogen, amino, cyano, nitro, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 -heterocyclyl and C 3-10 -cycloalkyl, wherein each of hydroxy, sulfanyl, sulfo, amino, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 -heterocyclyl and C 3-10 -cycloalkyl is optionally substituted with one or more substituents independently selected from hydroxy, sulfanyl, sulfo, oxo, halogen, amino, cyano, nitro, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 -heterocyclyl and C 3-10 -cycloalkyl, wherein each of hydroxy, sulfanyl, sulfo, amino, C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl, C 3-8 -heterocyclyl and C 3-10 -cycloalkyl is optionally substituted with one or more substituents independently selected from hydroxy, sulfanyl, sulfo, oxo, halogen, amino, cyano, nitro, C 1-6 -alkyl, C 2-6 -alkenyl, perhalomethyl and perhalomethoxy; and wherein R 2 is optionally covalently bound to R 1 by an ether, thioether C—C or C—N bond, to form a ring system with the N-atom to which R 1 and R 2 are bound; and X is O; and L is a group such that —C(═X)-L is a hydrolysable group; or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or any tautomeric forms, stereoisomers, mixture of stereoisomers, racemic mixture, or polymorphs thereof.