Patent ID: 8591905

Claim:
A composition comprising (1) synthetic nanocarriers comprising a polymeric or lipid surface presenting thereon an immunofeature surface formed of an array of a plurality of nicotine moieties having the structure shown below or a metabolite thereof, wherein the nicotine or metabolite is covalently bound to the polymer or lipid at one of R 1 -R 7 and the remainder of R 1 -R 7 are selected from the group consisting of H, alkyl, aryl, alkoxy, aryloxy, alkaryl, and aralkyl, any of which may be substituted or unsubstituted and may contain one or more heteroatoms; R 8 is an alkyl group; wherein the array binds to antigen presenting cell surfaces with high avidity and low affinity as compared to antibody binding; the nanocarriers optionally comprising one or more targeting agents recognizing a target associated with a particular organ, tissue, cell, or subcellular locale and optionally comprising one or more immunomodulatory agents inducing an immune response in B or T cells, or stimulating the immune system in a manner that enhances, suppresses, directs, or redirects an immune response, and (2) a pharmaceutically acceptable excipient.