Patent ID: 7317023

Claim:
A compound of formula (I): wherein: each of R 1 , R 2 , R 3 , and R 4 is independently selected from hydrogen, hydroxy, amino, halo, —CH 2 OH and —NHCHO, or R 1 and R 2 taken together are selected from —NHC(═O)CH═CH—, and —CH═CHC(═O)NH—; R 5 and R 6 are independently selected from hydrogen, hydroxy, halo, C 1-6 alkoxy, C 1-6 alkyl, —C 1-6 alkylenyl-NR a R b , —O—C 1-6 alkyleny-NR a R b ; —O—C 1-4 alkylenyl-O—C 1-4 alkylenyl-NR a R b , —SO 2 NR a R b , —NR c R d , phenyl, and heteroaryl; provided that R 5 and R 6 are not both hydrogen; wherein each phenyl is optionally substituted with 1 or 2 substituents selected from R f ; each heteroaryl is optionally substituted with 1 or 2 substituents selected from R g ; and each C 1-6 alkyl is optionally substituted with 1 to 3 substituents selected from halo, hydroxy, C 1-6 alkoxy, and amino; R 7 is hydrogen or C 1-6 alkyl; R 8 is hydrogen or C 1-6 alkyl; R 9 is hydrogen or C 1-6 alkyl; R 10 is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, aryl, heteroaryl, cycloalkyl, and heterocyclyl; or R 9 together with R 10 is —CH 2 —or —CH 2 CH 2 —; R a , R b , R c , R d , and R e are each independently hydrogen or C 1-6 alkyl, wherein each C 1-6 alkyl is optionally substituted with 1 to 3 substituents selected from hydroxy, C 1-6 alkoxy, and amino; or R a and R b , or R c and R d together with the nitrogen atom to which they are attached form a heteroaryl or heterocyclic ring having from 4 to 7 ring atoms, and containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur; R f is selected from hydroxy, halo, C 1-6 alkoxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(═O)OH, —CN, —NO 2 , —C(═O)R e , —SO 2 —C 16 alkyl, —C 1-6 alkylenyl-NR a R b , and —C(═O)NR a R b , wherein each C 1-6 alkyl is optionally substituted with 1 to 3 substituents selected from halo, hydroxy, C 1-6 alkoxy, and amino; and R g is C 1-6 alkyl or oxo, wherein each C 1-6 alkyl is optionally substituted with 1 to 3 substituents selected from halo, hydroxy, C 1-6 alkoxy, and amino; or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.