Patent ID: 7437249

Claim:
A system for removing trends in signal intensity values from features on a chemical array, said system comprising: a processor; one or more sequences of instructions for removing trends, wherein execution of said one or more sequences of instructions by said processor causes said processor to perform operations comprising: inputting signal intensity values from all features on the array except signal intensity values from features removed by filtering to remove at least features having the lowest signal intensity values and control features; calculating a log transform of each signal intensity value inputted from said all features on the array except signal intensity values from features removed by filtering to remove at least features having the lowest signal intensity values and control features, to provide log signal intensity values; calculating a surface approximation of the log signal intensity values; normalizing surface fit values on the calculated surface approximation in locations corresponding to locations of the features on the array from which signal intensity values were inputted; calculating a reverse log transform of the normalized surface fit values; and de-trending the inputted signal intensity values as a function of the normalized surface values in locations corresponding to the locations of the features from which the signal intensity values were inputted; and an interface through which de-trended signal intensity values are outputtable.