Patent ID: 8153789

Claim:
A process for preparing a compound of formula (I) wherein: X is CO or SO 2 ; R 1 and R 2 are independently selected from the group consisting of hydrogen, linear or branched alkyl(C 1 -C 6 ), alkenyl(C 1 -C 6 ), alkynyl(C 1 -C 6 ), cycloalkyl(C 3 -C 6 ), haloalkyl(C 1 -C 6 ), hydroxy, —O-alkyl(C 1 -C 6 ), phenoxy, —S-alkyl(C 1 -C 6 ), phenylthio, halogen, nitro, cyano, amino, alkylamino(C 1 -C 6 ), dialkylamino(C 1 -C 6 ), pyrrolidinyl, morpholinyl, piperidinyl, N-alkyl(C 1 -C 6 )piperazinyl, phenyl optionally substituted by 1 to 5 Z groups, and heteroaryl optionally substituted by 1 to 5 Z groups; R 3 and R 4 are independently selected from the group consisting of hydrogen, linear or branched alkyl(C 1 -C 6 ), alkenyl(C 2 -C 6 ), alkynyl(C 1 -C 6 ), cycloalkyl(C 3 -C 6 ), hydroxyalkyl(C 1 -C 6 ), amino, —NH-alkyl(C 1 -C 6 ), —N-dialkyl(C 1 -C 6 ), pyrrolidinyl, morpholinyl, piperidinyl, —N-alkyl(C 1 -C 6 )piperazinyl, —N-acyl(C 1 -C 6 )piperazinyl, phenyl optionally substituted by 1 to 5 Z groups, and heteroaryl optionally substituted by 1 to 5 Z groups, or both R 3 and R 4 can form, together with the nitrogen atom to which they are attached, a 5-6 membered heterocyclic ring optionally substituted by 1 to 5 Z groups, with the proviso that R 3 and R 4 are not simultaneously hydrogen; Z is selected from the group consisting of linear or branched alkyl(C1-C6), alkenyl(C 2 -C 6 ), alkynyl(C 1 -C 6 ), cycloalkyl(C 3 -C 5 ), haloalkyl(C 2 -C 6 ), hydroxy, —O-alkyl(C 1 -C 6 ), phenoxy, —S-alkyl(C 1 -C 6 ), phenylthio, halogen, nitro, cyano, amino, alkylamino(C 1 -C 6 ), and dialkylamino(C 1 -C 6 ), comprising reacting an intermediate (V): wherein R 2 , R 3 , R 4 , and X are as defined above, with a substituted 3-aminopyridazine (VI): wherein R 1 is as defined above.