Patent ID: 7994317

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: is a 6-membered aryl or heteroaryl ring; R 1 is hydrogen, CO 2 H, CO 2 (C 1 -C 6 )alkyl, CONR′R″ wherein R′ and R″ are each independently hydrogen or (C 1 -C 6 )alkyl, araalkyl, heteroaralkyl, —(C 2 -C 10 )alkylene-NR′R″, —(C 2 -C 10 )alkylene-OR′, and —O—(C 1 -C 6 )alkyl, —S—(C 1 -C 6 )alkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 halo; each R 2 is if present independently halo, (C 1 -C 6 )alkyl, —O—(C 1 -C 6 )alkyl, —S—(C 1 -C 6 )alkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 halo; n is 0 or 1; x is 0, 1, or 2; R 3 is hydrogen or (C 1 -C 6 )alkyl; p is 0, 1, 2, or 3; each R 4 if present is independently halo, (C 1 -C 6 )alkyl, or —O—(C 1 -C 6 )alkyl, —S—(C 1 -C 6 )alkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 halo, or taken together with the attached carbon forms C═O; y is 0, 1, or 2; R 5 is hydrogen or (C 1 -C 6 )alkyl; R 6 is hydrogen or (C 1 -C 6 )alkyl; R 7 is hydrogen, halo, or (C 1 -C 6 )alkyl; or R 6 and R 7 together with the atoms to which they are attached, form a 3-10 membered ring, optionally substituted on carbon with 1, 2, or 3 groups selected from halo, (C 1 -C 6 )alkyl, and —O—(C 1 -C 6 )alkyl, —S—(C 1 -C 6 )alkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 halo, or taken together with the attached carbon forms C═O; R 8 is hydrogen, halo, or (C 1 -C 6 )alkyl, or is wherein indicates the point of attachment and wherein R 9 is hydrogen, halo, or (C 1 -C 6 )alkyl; X is absent or is O, S(O) m wherein m is 0, 1, or 2, —CH 2 —S—, —CH 2 —O—, —CH 2 —NH—, or —CH 2 —N(C 1 -C 6 )alkyl-; is (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )heterocycloalkyl, aryl, or heteroaryl; each R 10 if present is independently halo, (C 1 -C 6 )alkyl, —O—(C 1 -C 6 )alkyl, —S—(C 1 -C 6 )alkyl, any of which may be optionally substituted on carbon with 1, 2, or 3 halo, or taken together with the attached carbon forms C═O; z is 0, 1, or 2; Z 1 , Z 2 , and Z 3 are N; Y is H, halo, OR 11 , or NR 11 R 12 ; R 11 is hydrogen or (C 1 -C 6 )alkyl; and R 12 is hydrogen, (C 1 -C 6 )alkyl, aryl, aralkyl, (C 3 -C 6 )cycloalkyl, -alkylene-(C 3 -C 6 )cycloalkyl, (C 3 -C 6 )heterocycloalkyl, -alkylene-(C 3 -C 6 )heterocycloalkyl, heteroaryl, heteroaralkyl, any of which may be optionally substituted on carbon with 1 or 2 groups selected from halo, (C 1 -C 6 )alkyl, —O—(C 1 -C 6 )alkyl, —S—(C 1 -C 6 )alkyl.