Patent ID: 8030308

Claim:
A compound of formula (I): wherein: V is —C(R 7 )—; W is a single bond; X is N(R 10 ); Y is —C(R 11 R 12 )C(R 13 R 14 ) or —C(R 11 )═C(R 12 )—; R 1 , R 2 , R 3 , R 4 and R 5 independently from each other are hydrogen, halogen, cyano, hydroxy, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, lower-alkyl-C(O), lower-alkyl-C(O)—NH, lower-alkyl-C(O)—N(lower-alkyl), lower-alkyl-S(O) 2 , NH 2 —S(O) 2 , N(H,lower-alkyl)-S(O) 2 or N(lower-alkyl) 2 -S(O) 2 , NH 2 —C(O), N(H,lower-alkyl)-C(O), N(lower-alkyl) 2 -C(O), COOH or lower-alkoxy-C(O), wherein lower-alkyl is optionally substituted with hydroxy, NH 2 , N(H,lower-alkyl) or N(lower-alkyl) 2 ; R 6 is an aryl or heteroaryl group, which aryl or heteroaryl group is optionally substituted by 1 to 4 substituents selected from the group consisting of halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, lower-alkyl-C(O), lower-alkyl-C(O)—NH, lower-alkyl-C(O)—N(lower-alkyl), lower-alkyl-S(O) 2 , NH 2 —S(O) 2 , N(H,lower-alkyl)S(O) 2 , N(lower-alkyl) 2 -S(O) 2 , NH 2 —C(O), N(H,lower-alkyl)-C(O), N(lower-alkyl) 2 -C(O), lower-alkoxy-C(O), COOH, 1H-tetrazol-5-yl, 5-oxo-4H-[1,2,4]oxadiazol-3-yl, 5-oxo-4H-[1,2,4]thiadiazol-3-yl, 5-thioxo-4H-[1,2,4]oxadiazol-3-yl, 2-oxo-3H-[1,2,3,5]oxathiadiazol-4-yl, SO 3 H, 3-hydroxy-isooxazol-5-yl, 6-oxo-6H-pyran-3-yl, 6-oxo-6H-pyran-2-yl, 2-oxo-2H-pyran-3-yl, 2-oxo-2H-pyran-4-yl and P(O)(OCH 2 CH 3 )OH, wherein lower-alkyl is optionally substituted with COOH, hydroxy, NH 2 , N(H,lower-alkyl) or N(lower-alkyl) 2 , and wherein fluoro-lower-alkyl is optionally substituted with hydroxy; R 7 is hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, hydroxy or hydroxy-lower-alkyl; R 10 is hydrogen, lower-alkyl, cycloalkyl, lower-alkyl-C(O), lower-alkyl-S(O) 2 , lower-alkoxy-C(O), (lower-alkyl)NH—C(O), or (lower-alkyl) 2 N—C(O); R 11 , R 12 , R 13 , and R 14 independently from each other are hydrogen, halogen, hydroxy, lower alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, hydroxy-lower-alkyl, aryl, COOH, C(O)O-lower-alkyl or cyano; or a pharmaceutically acceptable salt or ester thereof.