Patent ID: 7632817

Claim:
A method for the treatment of a disorder linked to the appearance of antibodies against endogenous factor VIII, exogenous factor VIII, derivatives thereof, recombinant or non-recombinant versions thereof, or in subjects suffering from hemophilia A, said method comprising administering mimotope decoys of factor VIII to said subjects, wherein said mimotope decoys of factor VIII are of the formula: (X 1 ) n1 -C-X 7 -X 8 -W-X 9 -N-R-X 10 -X 11 -(X 12 )n 13 -C-(X 2 ) n2 , in which: n 1 , n 2 , n 12 and n 13 each independently represent 0 or 1; X 1 is Y,E,Q,S,R,A,K,N, or T; X 2 is R,T,H,G,S,L,V,P,F,D,K,A,Q or I; X 7 is H, S, T, M, Q, or G; X 8 is T, A, K, R, Q, or E; X 9 is S, A, H, F, V, G, or T; X 10 is R, K, L, S, H, T, I, or A; X 11 is S, T, V, K, R, Y, M, or D; X 12 is S, R, or L; and X 11 is I, H, or W.