Patent ID: 7776834

Claim:
An immunostimulatory oligonucleotide having a structure from the group of 5′-TCTGTR′GTTC 1 U 1 -X-U 1 C 1 TTGR′TGTCT-5′ (5′-SEQ ID NO: 3-3′-X-3′-SEQ ID NO: 3-5′); 5′-CTGTR′GTTCU 1 C 1 -X-C 1 U 1 CTTGR′TGTC-5′ (5′-SEQ ID NO: 5-3′-X-3′-SEQ ID NO: 5-5′); 5′-CTGTR′GTTC 1 U 1 C 1 -X-C 1 U 1 C 1 TTGR′TGTC-5′ (5′-SEQ ID NO: 6-3′-X-3′-SEQ ID NO: 6-5′); 5′-TCTGTR′GTTCT-X-CGTTCGAACGT-5′ (5′-SEQ ID NO: 7-3′-X-3′-SEQ ID NO: 17-5′); 5′-TCTGTR′GACAG-X-GACAGR′TGTCT-5′ (5′-SEQ ID NO: 8-3′-X-3′-SEQ ID NO: 8-5′); 5′-TCTGTR′GACA 1 G 1 -X-G 1 A 1 CAGR′TGTCT-5′ (5′-SEQ ID NO: 9-3′-X-3′-SEQ ID NO: 9-5′); 5′-TCAGTR′GTTAG-X-GATTGR′TGACT-5′ (5′-SEQ ID NO: 10-3′-X-3′-SEQ ID NO: 10-5′); 5′-TCAGTR′GACTG-X-GTCAGR′TGACT-5′ (5′-SEQ ID NO: 11-3′-X-3′-SEQ ID NO: 11-5′); 5′-TR′GTR′GAR′GAT-X-TAGR′AGR′TGR′T-5′(5′-SEQ ID NO: 12-3′-X-3′-SEQ ID NO: 12-5′); 5′-TR′GTR′GTAGTA-X-ATGATGR′TGR′T-5′ (5′-SEQ ID NO: 13-3′-X-3′-SEQ ID NO: 13-5′); 5′-TR′GAAR′GTTCT-X-TCTTGR′AAGR′T-5′ (5′-SEQ ID NO: 14-3′-X-3′-SEQ ID NO: 14-5′); and 5′-TR′GTAR′GTACT-X-TCATGR′ATGR′T-5′ (5′-SEQ ID NO: 15-3′-X-3′-SEQ ID NO: 15-5′), wherein R′=1-(2′-deoxy-β-D-ribofuranosyl)-2-oxo-7-deaza-8-methyl-purine; A 1 /C 1 /G 1 /U 1 =2′-O-methyl-ribonucleotides; R=2′-deoxy-7-deazaguanosine and X=glycerol linker.