Patent ID: 7151109

Claim:
A compound of formula I: a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, wherein: R 1 is selected fron —H, —NR 7 R 8 , —OR 7 , —S(O) m R 7 , —C(O)R 7 , —C(S)R 7 , —C(O)OR 7 , —C(S)OR 7 , —C(O)NR 7 R 8 , —C(S)NR 7 R 8 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, and substituted heteracycloalkyl; R 2 is selected from —NR 7 R 8 ; R 3 , R 4 and R 5 can be the same or different and are independently selected from —H, alkyl, substituted alkyl, R 6 is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl, and —NR 11 R 12 ; R 7 and R 8 (1) can be the same or different and are independently selected from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, hereroaryl, and substituted heteroaryl, provided that R 7 and R 8 are not both H; or (2) when both R 7 and R 8 are alkyls and attached to a nitrogen, may form, along with the nitrogen, a 3–8 membered mono heterocyclic ring, which may be optionally substituted with 1 to 3 substituents selected from halogen, —R 9 , —OR 9 , —S(O) m R 9 , —NR 9 R 10 , —C(O)R 9 , —C(S)R 9 , —CN, —C(O)NR 9 R 10 , —C(S)NR 9 R 10 , —NR 9 C(O)R 10 , —NR 9 C(S)R 10 , —S(O) n NR 9 R 10 , —NR 9 S(O) n R 10 , —NO 2 , —C(O)OR 9 and —C(S)R 9 , or (3) when R 7 and R 8 are attached to a nitrogen and R 7 is alkyl and R 8 is either cycloalkyl or aryl, substituted aryl, heteroaryl, and substituted heteroaryl, form a 7–12 meinbered bicyclic heterocyclic ring, which may be optionally substituted with 1 to 3 substituents selected from halogen, —R 9 , —OR 9 , —S(O) m R 9 , —NR 9 R 10 , —C(O)R 9 , —C(S)R 9 , —CN, —C(O)NR 9 R 10 , —C(S)NR 9 R 10 , —NR 9 C(O)R 10 , —NR 9 C(S)R 10 , —S(O) n NR 9 R 10 , —NR 9 S(O) n R 10 , —NO 2 , —C(O)OR 9 and —C(S)OR 9 ; R 9 and R 10 can be the same or different and are independently selected from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, and aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 11 and R 12 (1) can be the same or different and are independently selected from H, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl, or (2) can form a 5- or 6-membered monocylic or a 8–10-membered bicyclic heteroaryl ring system, which may optionally contain, in addition to the nitrogen, an additional heteroatom selected from N, S, and O, and which may optionally have an oxo substituent on the ring and also may be optionally substituted with 1 to 3 substituents selected from halogen, —R 9 , —OR 9 , —S(O) m R 9 , —NR 9 R 10 , —C(O)R 9 , —C(S)R 9 , —CN, —C(O)NR 9 R 10 , —C(S)NR 9 R 10 , —NR 9 C(O)R 10 , —NR 9 C(S)R 10 , —S(O) n NR 9 R 10 , —NR 9 S(O) n R 10 , —NO 2 , —C(O)OR 9 and —C(S)OR 9 ; m is 0, 1 or 2; and n is 1 or 2.