Patent ID: 7871622

Claim:
A method of delivering a diagnostic or therapeutic agent comprising: a) obtaining a stably tethered structure that has (i) two copies of a first monomer comprising a DDD moiety attached to a first antigen binding fragment, wherein the DDD moiety consists the peptide sequence of SEQ ID NO: 1 (DDD1) or SEQ ID NO: 2 (DDD2) from a dimerization and docking domain of human protein kinase A RIIα; and (ii) one copy of a second monomer comprising an AD moiety attached to a second antigen binding fragment, wherein the AD moiety consists the peptide sequence of SEQ ID NO: 3 (AD1) or SEQ ID NO: 4 (AD2) from an anchoring domain of an AKAP (A-kinase anchoring protein), wherein the two DDD moieties bind to the AD moiety to form a stably tethered structure and wherein the stably tethered structure has at least one binding site for a targetable construct selected from the group consisting of Histidine-Serine-Glycine (HSG) and Indium-DTPA (In-DPTA); b) administering the stably tethered structure to a subject; and c) administering to the subject a targetable construct HSG or In-DPTA that comprises at least one diagnostic or therapeutic agent.