Patent ID: 8440830

Claim:
A compound of formula I wherein ring D and ring E together form a fused ring system, which is one of the following groups A is (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy(C 1 -C 2 )alkyl, (C 1 -C 4 )alkylthio(C 1 -C 2 )alkyl, mono- or -di(C 1 -C 4 )alkylamino(C 1 -C 2 )alkyl, (C 3 -C 7 )cycloalkyl optionally substituted by R1 and/or R2, (C 3 -C 7 )cycloalkyl substituted by R3, azetidinyl optionally substituted by R1 and/or R2, pyrrolidinyl optionally substituted by R1 and/or R2, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, pyrimidinyl optionally substituted by R1 and/or R2, pyrimidinyl substituted by R8, triazinyl optionally substituted by R1 and/or R2, triazinyl substituted by R9; quinolinyl optionally substituted by R1 and/or R2, isoquinolinyl optionally substituted by R1 and/or R2, thienyl optionally substituted by R1 and/or R2, thiazolyl optionally substituted by R1 and/or R2 or indazolyl optionally substituted by R1 and/or R2; R1 is halogen, hydroxyl, cyano, nitro, amino, carboxyl, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkyl which is partially or completely substituted by fluorine, (C 1 -C 4 )alkoxy which is predominantly or completely substituted by fluorine, (C 1 -C 4 )alkoxy(C 1 -C 2 )alkyl, (C 1 -C 4 )alkoxycarbonyl, mono- or -di(C 1 -C 4 )alkylamino, or (C 1 -C 4 )alkylcarbonylamino; R2 is halogen, hydroxyl, amino, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkoxy or R1 and R2 when ortho to each other form a methylenedioxy or ethylenedioxy group; R3 is 3-pyridyl, or 4-pyridyl; R4 is phenyl, phenoxy, 4-methylpiperazinyl, benzylNHC(═O)NH—, or (C 1 -C 4 )alkylphenyl-sulfonylamino; R5 is (C 1 -C 4 )alkylphenylsulfonylamino or N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, pyrrolidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, morpholinyl- or thiomorpholinyl-ring; R8 is pyridyl or (C 1 -C 4 )alkylphenylsulfonylamino; R9 is piperidinyl; L is bond, —(CH 2 ) n S(O) 2 —, —C(═O)—, —C(═S)—, —(CH 2 ) n OC(═O)—, —(CH 2 ) n N(R10)C(═O)—, —(CH 2 ) n N(R10)C(═NR11)-, —(CH 2 ) n N(R10)C(═S)—, —C═C—C(═O)—, —N═C(R11)-, —(CH 2 ) n N(R10)C(═O)C(═O)—, —OCH 2 C(═O)—, —N(R10)C(═CR11)-, —N(R10)CH 2 C(═O)— or —N═C(NR11)-; R10 is hydrogen, (C 1 -C 4 )alkyl or (C 1 -C 4 ) alkoxy(C 1 -C 2 )alkyl; R11 is hydrogen, hydroxyl, cyano, nitro, or (C 1 -C 4 )alkyl; B is hydrogen, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, thienyl, or N(R12)R13 wherein R12 and R13 independently of one another are hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkylcarbonyl, or R12 and R13 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, pyrrolidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, morpholinyl- or thiomorpholinyl-ring; R14 is hydrogen or (C 1 -C 4 )alkyl; and n is an integer selected from 0 to 2; or a salt thereof.