Patent ID: 7612094

Claim:
A compound of the following formula: or an N-oxide or a pharmaceutically acceptable salt thereof, wherein R 1 is aryl, heteroaryl, aralkyl, or heteroaralkyl; each R a is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl; X is piperidinyl, piperazinyl, pyrrolidinyl, tetrahydrofuran, cyclohexyl, cyclopentyl, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.1]octane, 2-oxa-bicyclo[2.2.2]octane, 2-aza-bicyclo[2.2.2]octane, 3-aza-bicyclo[3.2.1]octane, or 1-aza-bicyclo[2.2.2]octane; Y is a bond, —C(O)—, —C(O)—O—, —O—C(O)—, —S(O) p —O—, —O—S(O) p —, —C(O)—N(R b )—, —N(R b )—C(O)—, —O—C(O)—N(R b )—, —N(R b )—C(O)—O—, —O—S(O) p —N(R b )—, —N(R b )—S(O) p —O—, —N(R b )—C(O)—N(R c )—, —N(R b )—S(O) p —N(R c )—, —C(O)—N(R b )—S(O) p —, —S(O) p —N(R b )—C(O)—, —C(O)—N(R b )—S(O) p —N(R c )—, —C(O)—O—S(O) p —N(R b )—, —N(R b )—S(O) p —N(R c )—C(O)—, —N(R b )—S(O) p —O—C(O)—, —S(O) p —N(R b )—, —N(R b )—S(O) p —, —N(R b )—, —S(O) p —, —O—, —S—, or —(C(R b )(R c )) q —, wherein each of R b and R c is independently hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; p is 1 or 2; and q is 1-4; R 2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl; each of A 1 and A 2 , independently, is O, S, N, or NR b ; provided that at least one of A 1 and A 2 is N; and m is 0, 1, 2, or 3; provided that when m≧2, two adjacent R a groups can join together to form a 4- to 8-membered optionally substituted cyclic moiety.