Patent ID: 7393953

Claim:
A compound of the formula: wherein: R 1 is a polyalkylene oxide; Y 1 is O, S or NR 2 ; R 2 is selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cyloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; L 1 is a bifunctional linker selected from the group consisting of —NH(CH 2 CH 2 O) n (CH 2 ) n NR 3 —, —NH(CH 2 CH 2 O) n C(O)—, —NH(CR 4 R 5 ) n OC(O)—, —C(O)(CR 4 R 5 ) n NHC(O)(CR 8 R 7 ) q NR 3 —, —C(O)O(CH 2 ) n O—, —C(O)(CR 4 R 5 ) n NR 3 —, —C(O)NH(CH 2 CH 2 O) n (CH 2 ) n NR 3 —, —C(O)O − (CH 2 CH 2 O) n NR 3 —, —C(O)NH(CR 4 R 5 ) n O—, —C(O)O(CR 4 R 5 ) n O—, —C(O)NH(CH 2 CH 2 O) n —, wherein R 3 , R 4 , R 5 , R 7 , and R 8 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cyloalkyls, aryls substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; R 6 is selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cyloalkyls, aryls substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy, NO 2 , haloalkyl and halogen; and n and q are each a positive integer; p is 0 or 1; and B is wherein Y 7 is O, S or NR 12′ ; and R 1′ -R 12′ are each independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-12 alkenyls, C 3-12 substituted alkenyls, C 3-12 alkynyls, C 3-12 substituted alkynyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy, C 1-6 heteroalkoxy, halo-, nitro-, cyano-, hydroxyl-, amino-, carboxy- and trifluoromethyl, (i) wherein the substituted alkyls, substituted cycloalkyls, substituted aryls and substituted heteroalkyls are independently substituted with the group consisting of halo, alkoxy, nitro, carboxy, amino, alkylamino, hydroxyl and mercapto; and (ii) wherein a carbon of the heteroalkyls and heteroalkoxy is independently substituted with the group consisting of O, N and S.