Patent ID: 7208280

Claim:
A method to identify an agent that decreases 101P3A11 protein activity, comprising: providing a first sample of cells and a second sample of cells, wherein the cells of each sample express 101P3A11; contacting the first sample with a candidate compound and measuring 101P3A11 protein activity in the first sample with the candidate compound; measuring 101P3A11 protein activity in the second sample, wherein the second sample has not been contacted with said candidate compound; comparing the measured 101P3A11 protein activity in said first and second samples; whereby a diminution in the 101P3A11 protein activity in said first sample as compared to said second sample identifies said compound as an agent that decreases 101P3A11 protein activity; wherein 101P3A11 protein is SEQ ID NO: 2866; and wherein said activity comprises 101P3A11-mediated cAMP accumulation or a downstream signaling effect thereof which is selected from the group consisting of: 101P3A11-mediated ERK phosphorylation; 101P3A11-mediated p38 phosphorylation; 101P3A11-mediated cell growth; 101P3A11-mediated O-alpha subunit activation; and 101P3A11-mediated cell adhesion.