Patent ID: 7176233

Claim:
A method of treating a mammalian cell proliferative disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound having the structure (I): wherein: each of R 1 , R 2 , and R 3 is independently selected from a group consisting —H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, substituted cycloalkyl, alkoxy, substituted alkoxy, thioalkyl, substituted thioalkyl, hydroxy, halogen, amino, amido, carboxyl, —C(O)H, acyl, oxyacyl, carbamate, sulfonamide or sulfuryl, each R 4 is independently selected from a group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl; each of E 1 , E 2 , E 3 and E 4 is independently selected from a group consisting —O, —NR 5 , or —S, wherein R 5 is —H or C 1 –C 6 alkyl; and x is an integer having the value between 0 and 8, thereby treating a mammalian cell proliferative disorder, wherein the disorder is characterized by the formation of a colorectal neoplasm.