Patent ID: 7897788

Claim:
A compound of formula I C1 wherein A represents cyano; B represents hydrogen; R 1 , R 2 , R 3 and R 4 independently represent hydrogen, alkyl, halogen, nitro, cyano or formyl; and R 5 and R 6 independently represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, heteroaryl, heteroaryl-alkyl, alkenyl, carboxyalkyl, cyanoalkyl, diphenylalkyl, aryl, aryl-alkoxy-aryl, aryl-alkyl, aryl-alkyl-aryl, arylcarbonyl-aryl or aryloxy-aryl, or R 5 and R 6 , together with the nitrogen atom to which they are attached, form a heterocyclic ring system; or a salt of the compound of formula I C1 ; with the proviso that the compound is not: {3-[(E)-2-cyano-2-(4-fluoro-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; [3-((E)-2-cyano-2-m-tolylcarbamoyl-vinyl)-indol-1-yl]-acetic acid; {3-[(E)-2-(3-bromo-phenylcarbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid; [3-((E)-2-cyano-2-phenylcarbamoyl-vinyl)-indol-1-yl]-acetic acid; [3-((E)-2-benzylcarbamoyl-2-cyano-vinyl)-indol-1-yl]-acetic acid; [3-((E)-2-cyano-2-o-tolylcarbamoyl-vinyl)-indol-1-yl]-acetic acid; [3-((E)-2-cyano-2-p-tolylcarbamoyl-vinyl)-indol-1-yl]-acetic acid; {3-[(E)-2-(4-bromo-phenylcarbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(4-ethyl-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(4-methoxy-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(4-ethoxy-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; [3-((E)-2-cyano-2-isopropylcarbamoyl-vinyl)-indol-1-yl]-acetic acid; {3-[(E)-2-cyano-2-(3-ethoxy-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-3-[[2-(1H-indol-3-yl)ethyl]amino]-3-oxo-1-propenyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(4-chloro-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-3-(4-methyl-piperidin-1-yl)-3-oxo-propenyl]-indol-1-yl}-acetic acid; {3-[(E)-2-(3-chloro-4-methyl-phenylcarbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(3-phenyl-propylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(2,3-dichloro-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-(5-chloro-2-methyl-phenylcarbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(4-methoxy-benzylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; {3-[(E)-2-cyano-2-(2-fluoro-phenylcarbamoyl)-vinyl]-indol-1-yl}-acetic acid; or {3-[(E)-2-cyano-3-oxo-3-(4-phenyl-piperazin-1-yl)-propenyl]-indol-1-yl}-acetic acid.