Patent ID: 7589099

Claim:
Compounds of Formula (I) where: R 1 is the U-X—Y group, in which: U is one of the following groups —COCHR 10 NH— or CON[(CH 2 ) n2 NHR 7 ]—CH 2 —, where R 10 is H or is selected from the group consisting of: linear or branched C 1 -C 4 alkyl, optionally substituted with C 6 -C 14 aryl or an amino-alkyl C 1 -C 4 ; R 7 is H or linear or branched C 1 -C 4 alkyl; n 2 is an integer number from 2 to 6; X is H or is a group selected among the following: —COCHR 3 NH—, —COCHR 6 (CH 2 ) n3 R 4 —, —R 4 —CH 2 (OCH 2 CH 2 ) n4 OCH 2 R 4 —, —R 4 (Q)R 4 —, —R 5 [Arg-NH(CH 2 ) n5 CO] n6 R 5 —, —R 5 —[N-guanidinopropyl-Gly] n6 R 5 —, in which n 3 is an integer number from 0 to 5, n 4 is an integer number from 0 to 50, n 5 is an integer number from 2 to 6, n 6 is an integer number from 2 to 7; R 3 is H or linear or branched C 1 -C 4 alkyl, optionally substituted with —COOH, —CONH 2 , —NH 2 or —OH; R 4 is selected from the group consisting of: —NH—, —CO—, —CONH—, —NHCO—; R 5 is either absent or is the group —R 4 (Q)R 4 —; R 6 is H or NH 2 ; Q is selected from the group consisting of: linear or branched C 1 -C 6 alkylene; linear or branched C 3 -C 10 cycloalkylene; linear or branched C 2 -C 6 alkenylene; linear or branched C 3 -C 10 cyclo-alkenylene; C 6 -C 14 arylene; arylene (C 6 -C 14 )-alkylene; (C 1 -C 6 ), alkylene (C 1 -C 6 )-arylene (C 6 -C 14 ); aromatic or non-aromatic heterocyclyl (C 3 -C 14 ), containing at least one heteroatom selected from the group consisting of O, N, S; Y is absent or H or is the following group c(Arg-Gly-Asp-AA 1 -AA 2 ), in which: c means cyclic; AA 1 is selected from the group consisting of: (D)-Phe, (D)-Trp, (D)-Tyr, (D)-2-naphthylAla, (D)-4-terbutyl-Phe, (D)-4,4′-biphenyl-Ala, (D)-4-CF 3 -Phe, (D)-4-acetylamine-Phe; AA 2 is selected from the group consisting of: NW—CH[(CH 2 ) n7 —CO]—CO, NW—CH[(CH 2 ) n7 —NH]—CO, NW—[4—(CH 2 ) n7 —CO]-Phe, NW—[4—(CH 2 ) n7 —NH]-Phe, [NW]-Gly, NW-Val, in which W is selected from H, linear or branched C 1 -C 6 alkyl, —(CH 2 ) n7 —COOH where n 7 is an integer number from 0 to 5, 4-carboxybenzyl, 4-aminomethylbenzyl; the N 1 -oxides, racemic mixtures, their single enantiomers, their single diastereoisomers, the forms E and Z, mixtures thereof, and their pharmaceutically acceptable salts.