Patent ID: 7351826

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: Ar represents phenyl, naphthyl or a 5- to 10-membered heteroaryl group, each of which is substituted with from 0 to 4 groups independently selected from R 8 ; R 1 is independently chosen at each occurrence from: (a) hydrogen, halogen, nitro and cyano; and (b) groups of the formula: wherein: G is a bond, C 1 —C 4 alkyl, —N(R B )—, —O—, —C(═O)—, —C(═O)N(R B )—, —N(R B )C(═O)—, —S(O) m —, —CH 2 C(═O)—, —S(O) m N(R B )— or —N(R B )S(O) m —; wherein m is 0, 1 or 2; and R A and each R B are independently selected from: (i) hydrogen; and (ii) C 1 -C 8 alkyl, C 2 -C 8 alkenyl, (C 3 -C 8 carbocycle)C 0 -C 4 alkyl and (3- to 8-membered heterocycle)C 0 -C 4 alkyl, each of which is substituted with from 0 to 4 substituents independently selected from halogen, hydroxy, nitro, cyano, amino, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkanoyl, mono- and di(C 1 -C 4 alkyl)amino, C 1 -C 4 haloalkyl and C 1 -C 4 haloalkoxy; R 4 is hydroxy, nitro, cyano, amino, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 haloalkoxy, C 2 -C 8 alkyl ether, C 2 -C 8 haloalalkyl ether, or mono- or di-(C 1 -C 8 alkyl)amino(C 0 -C 4 alkyl); R 5 and R 6 are independently hydrogen, methyl or ethyl; R 7 represents C 1 -C 8 alkyl, C 2 -C 8 alkenyl, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, or benzyl that is substituted with from 0 to 3 substituents independently chosen from halogen, nitro, trifluoromethyl, trifluoromethoxy, cyano and hydroxy; and R 8 is independently selected at each occurrence from halogen, hydroxy, nitro, cyano, amino, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 1 -C 8 alkynyl, (C 3 -C 7 cycloalkyl)C 0 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, (C 3 -C 7 cycloalkyl)C 1 -C 8 alkoxy, C 1 -C 8 haloalkoxy, C 2 -C 8 alkyl ether, C 3 -C 8 alkanone, C 1 -C 8 alkanoyl, (3- to 7-membered heterocycloalkyl)C 0 -C 8 alkyl, C 1 -C 8 hydroxyalkyl, C 1 -C 8 aminoalkyl, and mono- and di-(C 1 -C 8 alkyl)aminoC 0 -C 8 alkyl.