Patent ID: 7531181

Claim:
A multi-antigenic construct comprising two or more carbohydrate domains having the structure: wherein each occurrence of R 1 is independently hydrogen or an oxygen protecting group; each occurrence of R 2A and R 2B is independently hydrogen or a nitrogen protecting group; each occurrence of R 3 is independently hydrogen, a protecting group or a carbohydrate domain comprising a saccharide moiety having the structure: wherein Y is NH or O; wherein a, b and c are each independently 0, 1 or 2; d is an integer from 1-3; with the proviso that the d bracketed structure represents a furanose or pyranose moiety and the sum of b and c is 1 or 2; wherein R 0 is hydrogen, a linear or branched chain alkyl, acyl, arylalkyl or aryl group; wherein each occurrence of R 5 , R 6 and R 7 is independently hydrogen, OH, OR i , NR ii R iii , NHCOR i , F, CH 2 OH, CH 2 OR i , or a substituted or unsubstituted linear or branched chain alkyl, (mono-, di- or tri)hydroxyalkyl, (mono-, di- or tri)acyloxyalkyl, arylalkyl or aryl group; wherein each occurrence of R i , R ii and R iii is independently hydrogen, a protecting group, a sialic acid moiety, CHO, COOR iv , or a substituted or unsubstituted linear or branched chain alkyl, acyl, arylalkyl or aryl group, or R ii and R iii , taken together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocyclic or heteroaryl moiety; and wherein each occurrence of R iv is independently H, or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group; W 1 , W 2 and W 3 are independently R 1 , R 3 , or optionally substituted mannose, galactose or lactosamine moieties; wherein each carbohydrate domain is independently covalently bound to a linker system, said linker system being a cyclic peptide or dimerized peptide.