Patent ID: 7557100

Claim:
A compound of formula I: or a salt, solvate, or a hydrate thereof, wherein: R 1 is pyrazine, indicates a point of attachment; R 7 is H, halo, C 1-6 alkyl, C 3 -C 8 cycloalkyl, heterocyclyl, ether, —CN, —NR 8 R 9 , —OR 10 , —(CH 2 ) m OPO 3 (R p ) 2 , —(CH 2 ) m OC(═O)(CH 2 ) m CH 3 , —(CH 2 ) m OC(═O)(CH 2 ) m CO 2 R 6 , —(CH 2 ) m OC(═O)(CH 2 ) m NR 8 R 9 , —(CH 2 ) m OC(═O)E, —(CH 2 ) m CO 2 (CH 2 ) m CH 3 , —(CH 2 ) m CO 2 (CH 2 ) m CO 2 R 6 , —(CH 2 ) m CO 2 (CH 2 ) m NR 8 R 9 , —(CH 2 ) m CO 2 E, —(CH 2 ) m C(═O)NR 6 (CH 2 ) m CO 2 R 6 , —(CH 2 ) m C(═O)NR 8 R 9 , —(CH 2 ) m NR 8 R 9 , —(CH 2 ) m PO 3 (R 11 ) 2 , —(CH 2 ) m OR 10 , which is optionally substituted with —OR 11 , —(CH 2 ) m C(═O)OR 11 , —(CH 2 ) m NR 11 SO n R 12 , —(CH 2 ) m SO n R 12 , —(CH 2 ) m SO n NR 8 R 9 , aryl, or heteroaryl; each n is independently is 0, 1 or 2; R 10 is H, C 1-6 alkyl, —PO 3 H 2 , C(═O)R 13 , C(═O)OR 13 or C(═O)NR 8 R 9 and R 11 , R 12 and R 13 are independently H, C 1-6 alkyl, aminoalkyl, benzyl, phenyl, an amino acid residue or a peptide residue; R 2 and R 3 are independently H or C 1-6 alkyl; R 4 and R 5 are independently H, C 1-6 alkyl which is optionally substituted with halo, ether, —(CH 2 ) m aryl, benzyl, —O(CH 2 ) m aryl, —Obenzyl, —(CH 2 ) m NR 8 R 9 , —(CH 2 ) m OR 6 , —(CH 2 ) m OPO 3 (R p ) 2 , —(CH 2 ) m OC(═O)(CH 2 ) m CH 3 , —(CH 2 ) m OC(═O)(CH 2 ) m CO 2 R 6 , —(CH 2 ) m OC(═O)(CH 2 ) m NR 8 R 9 , —(CH 2 ) m OC(═O)E, or R 4 and R 5 together with the atoms to which they are attached form a heterocyclic ring; each m is independently 0, 1, 2 or 3; E is an ether; each R p is independently H, C 1-6 alkyl, benzyl, phenyl, or (R p ) 2 together with the atoms to which they are attached form a heterocyclic ring; each R 6 is independently H, C 1-6 alkyl, C 1-6 acyl or benzyl; R 8 and R 9 are independently H, C 1-6 alkyl or R 8 and R 9 together with the atom to which they are attached form a heterocyclic ring which is optionally substituted with C 1-6 alkyl; and X and Y are independently H, halo, C 1-6 alkyl, —OR 6 , —CN, a ether which is optionally substituted with halo, a heterocyclyl, or a amine.