Patent ID: 7723358

Claim:
An aroyl-O-piperidine compound of formula (I): in which: R 1 is hydrogen, alkyl, or alkoxy; R 2 is alkyl, alkoxy, methoxyethoxy, trifluoromethyl, or trifluoromethoxy; R 3 is hydrogen or alkyl; R 4 is hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, —C(═Z)—R 5 , in which Z is sulfur or oxygen, or is —S(O) 2 —R 6 , in which n is −1 or 2; R 5 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl, heteroarylalkyl, —O—R 7 , —C(═O)—O—R 7 , —S—R 8 , or —NR 9 R 10 ; R 6 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, aryl-alkyl, or heteroarylalkyl; R 7 is hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, or heteroarylalkyl; R 8 is hydrogen, alkyl, alkenyl, or alkynyl; R 9 hydrogen or alkyl; and R 10 is hydrogen, alkyl which is optionally substituted by —C(═O)—O—R 7 , alkenyl, alkynyl, —S(O) 2 —R 6 in which n represents 1 or 2, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, or heteroarylalkyl; wherein in each case the alkyl, alkenyl and alkynyl groups are optionally substituted by hydroxyl, linear or branched alkoxy having 1 to 6 carbon atoms, or —C(═O)—O—R 7 , and in each case the cycloalkyl, heterocyclyl, aryl and heteroaryl groups are optionally substituted by halogen, alkyl, alkoxy, alkylthio, cyano, nitro, hydroxyl, trifluoromethyl, trifluoromethoxy, —C(═O)—O—R 7 , or —NR 9 R 10 ; or a geometrical isomer, optical isomer, epimer, tautomeric form, oxidized form, or pharmaceutically acceptable salt thereof.