Patent ID: 7081464

Claim:
A topical pharmaceutical composition comprising a compound of the formula (I): in which: one of R 1 and R 2 is R 3 —X— and the other is hydrogen, nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, lower alkyl, lower alkoxy, halo, or R 3 —X—; R 7 is monocycloalkyl of up to 10 carbon atoms, polycycloalkyl of up to 10 carbon atoms, or benzocyclic alkyl of up to 10 carbon atoms; X is —CH 2 — or —O—; R 5 is a divalent pyrrolidine, imidazole, or thiophene ring in which the divalent bonds are on vicinal ring carbon atoms; R 6 —CO—, —CH 2 —, —CH 2 CO—, or —SO2—; Y is —COZ, —C≡N, —OR 8 , alkyl of 1 to 5 carbon atoms, or aryl; Z is —NH 2 , —OH, —NHR, -R 9 , —OR 9 , or alkyl of 1 to 5 carbon atoms; R 8 is hydrogen or lower alkyl; R 9 is alkyl or benzyl; n has a value of 0, 1, 2, or 3; and a pharmaceutically acceptable topical carrier.