Patent ID: 7138104

Claim:
A method of concurrent imaging of organ blood flow and vitronectin receptors sites in a mammal comprising: I) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and II) concurrently detecting the vitronectin receptor targeted imaging agent bound at the vitronectin receptor and the perfusion imaging agent; and III) forming an image from the detection of said vitronectin targeted imaging agent and said perfusion imaging agent; wherein the vitronectin receptor targeted imaging agent is a diagnostic metallopharmaceutical comprising 111 In, and a compound comprising: a) a chelator which is DOTA (1,4,7,10-tetraaza-4,7,10-tris(carboxymethyl)cyclododecane); and b) a targeting moiety which is bound to the chelator and is (2S)-2-[({2,6-dimethyl-4-(4-butoxyoyl)phenyl}sulfonyl)amino]-3-({7-[(imidazol-2-ylamino)methyl)]-1-methyl-4-oxo(3-hydroquinolyl)}-carbonylamino) propanoic acid; and c) a linking group between the targeting moiety and the chelator, which is 2-(2-aminoethylcarbonyl)-2-(2-amino-3-sulfo-propanoylamino)-ethanesulfonic acid; and wherein the perfusion imaging agent is 99m Tc sestamibi.