Patent ID: 6841389

Claim:
A method of determining glucose concentration G(t) in blood comprising: a) at a preliminary measurement stage, measuring the values of impedance or a component of impedance between the electrodes placed on the skin of a patient and invasively measuring the values of a glucose concentration G inv (t) of the patient; b) determining parameters a 0 , q and a 1 in an expression G ⁢ ( t ) = G 1 ⁢ e - a 0 ⁢ t + q + a 1 ⁢ e - a 0 ⁢ t ⁢ ∫ 0 t ⁢ N ⁢ ( x ) ⁢ e a 0 ⁢ x ⁢ ⅆ x ; by using the measured values of impedance or the component of impedance and the measured values of the glucose concentration G inv (t) and approximating G inv (t) to G(t); and c) independently of when and where steps a) and b) were performed, non-invasively measuring impedance or a component of impedance between electrodes placed on the skin of the patient and calculating the glucose concentration G(t) according to the expression, wherein step c) can be repeated without repeating steps a) and b).