Patent ID: 8153664

Claim:
A compound represented by structural formula I: or a pharmaceutically acceptable salt, ester or prodrug of said compound, wherein A is —N(H)— or —N(alkyl)-; W is 1-4 moieties and each W is independently selected from the group consisting of hydrogen; alkyl; fluoroalkyl; difluoroalkyl; trifluoroalkyl; cycloalkyl; heterocycloalkyl; R 21 -aryl; hydroxyalkyl; dihydroxyalkyl; aminoalkyl; alkylaminoalkyl; di-(alkyl)-aminoalkyl; alkoxy; halogen; —NR 4 R 5 ; —CN; —OH; aryl; or alkyl optionally substituted with —NR 1 R 2 , —NR 1 COR 2 , —NR 1 CONR 1 R 2 , —NR 1 C(O)OR 2 , —NR 1 S(O) 2 R 2 , —NR 1 S(O) 2 NR 1 R 2 , —C(O)OH, —C(O)OR 1 , —CONR 1 R 2 , hydroxyalkyl, or —S(O) 2 -alkyl; and —C(O)NR 4 R 5 ; R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, difluoroalkyl, trifluoroalkyl, alkoxy, hydroxyalkyl and arylalkyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, alkyl, phenyl, benzyl and cycloalkyl; R 10 is H or alkyl; R 11 is H or alkyl; R 13 is independently selected from hydrogen, alkyl, cycloalkyl, haloalkyl, halogen, and —(CH 2 ) n6 NHC(O)OR 16b , where n 6 is 0-4; R 14 is independently selected from the group consisting of hydrogen, alkyl, —OH, alkoxy, halogen and haloalkyl; R 16 is independently selected from the group consisting of hydrogen, alkyl, phenyl and benzyl; R 16b is hydrogen, alkoxy, alkyl, alkoxyalkyl-, R 22 —O—C(O)-alkyl-, cycloalkyl, R 21 -aryl, R 21 -arylalkyl, haloalkyl, alkenyl, halo substituted alkenyl, alkynyl, halo substituted alkynyl, or hydroxyalkyl; R 17 is independently selected from the group consisting of hydrogen, alkyl, phenyl and benzyl; R 32 and R 33 are independently selected from the group consisting of hydrogen and R 34 -alkyl, or R 32 and R 33 can be combined to form a ring structure Q, where Q is R 21 is 1 to 3 moieties and each R 21 is independently selected from the group consisting of hydrogen, —CN, —CF 3 , —OCF 3 , halogen, —NO 2 , alkyl, —OH, alkoxy, alkylamino-, di-(alkyl)amino-, —NR 25 R 26 alkyl-, hydroxyalkyl-, —C(O)OR 17 , —COR 17 , —NHCOR 16 , —NHS(O) 2 R 16 , —C(NH)—NH 2 , —NHS(O) 2 CH 2 CF 3 , —C(O)NR 25 R 26 , —NR 25 —C(O)—NR 25 R 26 , —SO 2 NR 4 R 5 and —CONR 4 R 5 ; R 22 is hydrogen, alkyl, phenyl or benzyl; R 25 and R 26 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, halocycloalkyl, alkoxyalkyl, hydroxy and alkoxy; and R 34 is 1 to 3 moieties and each R 34 is independently selected from the group consisting of hydrogen, halogen, —OH and alkoxy.