Patent ID: 7326785

Claim:
A method for preparing a compound of formula (I): wherein: R 1 represents hydrogen, —C 1-6 alkyl, —C 3-6 alkenyl, —C 2-3 alkylNR b R c , —C 2-3 alkylNHCOR b , phenyl being optionally substituted by halogen, or R 1 represents a group X—W, wherein X represents —C 1-3 alkylene- and W represents —CN, —CO 2 H, —CONR b R c , —COC 1-6 alkyl, —CO 2 C 1-6 alkyl, or phenyl, the phenyl being optionally substituted by one or more substitutents selected from: —C 1-3 alkyl, —C 1-3 alkoxy, —C 1-3 alkylOH, halogen, —CN, —CF 3 , —NH 2 , —CO 2 H and —OH; R 2 and R 3 independently represent hydrogen, —C 1-3 alkyl or —CF 3 with the proviso that one of R 2 and R 3 is —C 1-3 alkyl or —CF 3 and the other is hydrogen; R b and R c independently represent hydrogen or —C 1-3 alkyl; A represents: Z represents one or two optional substituents independently selected from halogen and OH, B represents one or more optional substituents on ring carbon atoms selected from: (i) one or more substituents selected from —CF 3 , —F, —CO 2 H, —C 1-6 alkyl, —C 1-6 alkylOH, —(C 1-3 alkyl)NR b R c , —(C 0-3 alkyl)CONR b R c and —(C 0-3 alkyl)CO 2 C 1-3 alkyl, —CONHC 2-3 alkylOH, —CH 2 NHC 2-3 alkylOH, —CH 2 OC 1-3 alkyl and —CH 2 SO 2 C 1-3 alkyl; (ii) a group —Y—R e , Y represents —C 1-3 alkylene-, —CO—, —C 1-3 alkylNH—, —C 1-3 alkylNHCO—, —C 1-3 alkylNHSO 2 —, —CH 2 NHSO 2 CH 2 — or a direct link, R e represents phenyl, a 5- or 6-membered cycloalkyl or a 5- or 6-membered heterocycle consisting of at least one heteroatom selected from O or S, each of which is optionally substituted by one or more substituents selected from: —C 1-3 alkyl, —C 1-3 alkoxy, —C 1-3 alkylOH, halogen, —CN, —CF 3 , —NH 2 , —CO 2 H and —OH; or (iii) a second ring R f which is fused to the heterocyclic ring, wherein R f represents phenyl, a 5- or 6-membered cycloalkyl group or a 5- or 6-membered aromatic heterocyclic group consisting of at least one heteroatom selected from O, N or S, and the fused bicyclic group is optionally substituted by one or more substituents selected from: —C 1-3 alkyl, —C 1-3 alkoxy, —C 1-3 alkylOH, halogen, —CN, —CF 3 , —NH 2 , —CO 2 H and —OH; wherein said method comprises the step of reacting a compound of formula (II) with a compound of formula (III):