Patent ID: 8491913

Claim:
A method for treating damage caused by stroke in a mammalian subject comprising: administering to the mammalian subject who has suffered a stroke an immune-modulatory effective amount of a composition comprising a purified MHC class II polypeptide comprising covalently linked first and second domains, wherein the first domain is a mammalian MHC class II β1 domain and the second domain is a mammalian MHC class II α1 domain, wherein the amino terminus of the second domain is covalently linked to the carboxy terminus of the first domain, and wherein the MHC class II molecule does not include an α2 or a β2 domain; and an antigenic determinant, wherein the antigenic determinant is MOG 35-55, wherein the MHC class II polypeptide modulates one or more immune responses or immune regulatory activities of a T-cell in said subject.