Patent ID: 8580834

Claim:
An isolated compound having the structure: or a tautomer, salt, hydrate, or ester thereof; wherein X is O; and R is one or more substituents selected from the group consisting of hydrogen, halogen; hydroxy; nitro; CN; aryl; heteroaryl; —C(═O)R a ; —NR b R c ; —S(O) n R d where n=0-2; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen and C 1-6 alkyl; an optionally substituted fused aromatic or non-aromatic 5-6 membered monocyclic ring optionally containing 1-3 heteroatoms selected from the group consisting of N, O, and S; and C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 3-6 cycloalkyl, each independently optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; each occurrence of R a is independently selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, aryl, heteroaryl, and NR b R c , wherein C 1-6 alkyl and C 1-6 alkoxy are optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; each occurrence of R b and R c is independently selected from the group consisting of hydrogen; hydroxy; SO 2 R d ; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro and N(R e ) 2 ; aryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e ) 2 ; and heteroaryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e ) 2 ; each occurrence of R d is independently selected from the group consisting of hydrogen; N(R e ) 2 ; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; aryl and heteroaryl; and each occurrence of R e is independently hydrogen or C 1-6 alkyl.