Patent ID: 8143380

Claim:
A compound comprising a structure set out in Formula V [F 1 -(L 2 ) e -P 1 -(L 3 ) f -P 2 ]-(L 1 ) c -PEG d Formula V wherein: F 1 is an Fc domain; wherein P 1 and P 2 are each independently sequences of pharmacologically active peptides; L 1 , L 2 and L 3 are each independently linkers; c, e and f are each independently 0 or 1; d is at least 1; and wherein the Fc domain is attached at the N-terminus of -L 2 -P 1 -L 3 -P 2 and one or more PEG is attached to any reactive moiety in the Fc domain, optionally through linker L 1 ; said compound having a property of improved bioefficacy when administered in a multidose regimen.