Patent ID: 8124405

Claim:
A single chain, polypeptide fusion protein having an N-terminus and a C-terminus, said fusion protein comprising: (a) an L-chain of a botulinum neurotoxin; (b) a PAR1 ligand located C-terminal of the L-chain; (c) a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the L-chain and the PAR1 ligand; and (d) a translocation domain that comprises the H N domain of a botulinum neurotoxin; wherein the PAR1 ligand is located between the protease cleavage site and the translocation domain; and wherein the fusion protein lacks the natural binding function of the Hc component of a clostridial neurotoxin H-chain.