Patent ID: 7282481

Claim:
A functionalized heparin-binding protein comprising a heparin-binding protein and at least one sugar chain covalently bonded thereto, wherein the at least one sugar chain is selected from the group consisting of a sulfated polysaccharide, a glycosaminoglycan, and an O-linked sugar chain, wherein the DNA synthesis promoting activity of the heparin-binding protein is increased by adding the at least one covalently bonded sugar chain, wherein the functionalized heparin-binding protein comprises the amino acid sequence of SEQ ID NO: 1, 17, 19, 21 or 23 and wherein the at least one sugar chain is covalently bonded to the N-terminal peptide sequence of SEQ ID NO: 1, 17, 19, 21 or 23, wherein the N-terminal peptide sequence consists of residues 1-86 in SEQ ID NO: 1, residues 1-65 in SEQ ID NO: 17, residues 1-65 in SEQ ID NO: 19, residues 1-119 in SEQ ID NO: 21, and residues 1-146 in SEQ ID NO: 23.