Patent ID: 7365071

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof with a base or acid: in which; n is 1; R1 is selected from the group consisting of hydrogen, alkyl having up to 8 carbon atoms and (CH 2 ) n ′R 0 1 in which n′ is 0 or 1 and R 0 1 is selected from the group consisting of aryl having up to 12 carbon atoms; heteroaryl having up to 15 carbon atoms and at least one heteroatom selected from N, S, and O; COR′; CONR′R″; CSNR′R″; COCOOR′; SO 2 NR′R″; SO 2 R′; CO 2 R′ and CN; R′ is selected from the group consisting of hydrogen, alkyl having up to 8 carbon atoms, alkenyl having up to 8 carbon atoms, aralkyl having up to 12 carbon atoms and aryl having up to 12 carbon atoms; R″ is selected from the group consisting of hydrogen; alkyl having up to 8 carbon atoms; aryl having up to 12 carbon atoms; aralkyl having up to 12 carbon atoms; SO 2 —R′ and COR′; in each case R′ being independently selected from the group consisting of hydrogen, alkyl having up to 8 carbon atoms, alkenyl having up to 8 carbon atoms, aralkyl having up to 12 carbon atoms and aryl having up to 12 carbon atoms; R2 is selected from the group consisting of hydrogen, halo, alkyl, OH, Oalkyl, NO 2 , NH 2 , NHalkyl, N(alkyl) 2 , NHCOalkyl, NHSO 2 alkyl, CONHalkyl, SO 2 NHalkyl, COOH, COOalkyl, CN, OSO 2 alkyl, NHCONHalkyl and COalkyl; said alkyl having up to 8 carbon atoms; X is a divalent group —C(O)—N(OR 3 )— connected to the ring nitrogen atom via its carbonyl carbon atom and to the ring carbon atom via its nitrogen atom, in which R 3 is selected from the group consisting of hydrogen and the R, Y, Y 1 , Y 2 and Y 3 moieties defined below; R is selected from the group consisting of alkyl having up to 6 carbon atoms, optionally substituted by pyridyl or carbamoyl; alkenyl having up to 8 carbon atoms; aryl having up to 12 carbon atoms; and aralkyl having up to 12 carbon atoms; each said aryl group optionally being substituted by an —OH, —NH 2 , —NO 2 , alkyl having up to 8 carbon atoms, an alkoxy having up to 8 carbon atoms or by one or more halogens; Y is selected from the group consisting of COR, COOH, COOR, CONHR, CONHOH, CONHSO 2 R, CH 2 COOH, CH 2 COOR, CH 2 CONHOH, CH 2 CONHCN, CH 2 tetrazole, CH 2 (protected tetrazole), CH 2 SO 3 H, CH 2 SO 2 R, CH 2 PO(OR) 2 , CH 2 PO(OR)(OH), CH 2 PO(R)(OH) and CH 2 PO(OH) 2 , wherein R is as defined hereinabove; Y 1 is selected from the group consisting of SO 2 R, SO 2 NHCOR, SO 2 NHCOOR, SO 2 NHCONHR and SO 3 H, wherein R is as defined hereinabove; Y 2 is selected from the group consisting of PO(OH) 2 , PO(OR) 2 , PO(OH)(OR) and PO(OH)(R), wherein R is as defined hereinabove; Y 3 is selected from the group consisting of tetrazole, tetrazole substituted by R, squarate, NRtetrazole, NRtetrazole substituted by R, and NRSO 2 R, wherein R is as defined above, including the pure enantiomers thereof, in the R, S or RS configuration, as well as any racemic mixture of said enantiomers.