Patent ID: 7649002

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 is a —(C 1 -C 6 )alkyl, —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, —(C 3 -C 8 )cycloalkyl, —(C 5 -C 8 )cycloalkenyl, —(C 1 -C 2 )alkyl(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 2 )alkylaryl, heterocyclic, or —(C 1 -C 2 )alkylheterocyclic group wherein each R 1 group is optionally substituted with one to four groups independently selected from: —(C 1 -C 4 alkyl, —(CH 2 ) m (C 3 -C 5 )cycloalkyl, halogen, —(CH 2 ) m OR 6 , —CN, —C(O)OR 6 , —(CH 2 ) m NR 7 SO 2 R 8 , CF 3 , CH 2 CF 3 , OCF 3 and OCH 2 CF 3 ; m at each occurrence is independently 0, 1 or 2; R 2 is H, OH or OCH 3 ; R 3 is a H, —(C 1 -C 6 )alkyl, —(C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkynyl, —(C 3 -C 8 )cycloalkyl, —(C 5 -C 8 )cycloalkenyl, —(C 1 -C 2 )alkyl(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 2 )alkylaryl, heterocyclic, or —(C 1 -C 2 )alkylheterocyclic group each R 3 group other than H is optionally substituted with one to four groups independently selected from: —OH, —(C 1 -C 4 )alkyl, —(CH 2 ) n (C 3 -C 5 )cycloalkyl, halogen, —CN, —(CH 2 ) n OR 6 and —(CH 2 ) n NR 7 R 8 ; n at each occurrence is independently 0, 1 or 2; R 4 is —H, —(C 1 -C 4 alkyl, —(C 2 -C 4 )alkenyl, —(C 2 -C 4 )alkynyl, —(CH 2 ) p (C 3 -C 5 )cycloalkyl, —(CH 2 ) p (C 5 )cyclo-alkenyl, halogen, —(CH 2 ) p OR 6 , —(CH 2 ) p NR 7 R 8 , —CN, —O(O)R 6 , —O(O)OR 6 , —O(O)NR 7 R 8 , —(CH 2 ) p NR 7 SO 2 R 8 , CF 3 , CH 2 CF 3 , OCF 3 or OCH 2 CF 3 ; R 5 is —(C 1 -C 4 )alkyl, —(C 2 -C 4 )alkenyl, —(C 2 -C 4 )alkynyl, —(CH 2 ) p (C 3 -C 5 )cycloalkyl, —(CH 2 ) p (C 5 )cyclo-alkenyl, halogen, —(CH 2 ) p OR 6 , —(CH 2 ) p NR 7 R 8 , —CN, —O(O)R 6 , —O(O)OR 6 , —C(O)NR 7 R 8 , —(CH 2 ) p NR 7 SO 2 R 8 , CF 3 , CH 2 CF 3 , OCF 3 or OCH 2 CF 3 ; or R 4 and R 5 are taken together with the carbons to which they are attached to form a fused 5- to 7-membered unsaturated or partially unsaturated ring; p at each occurrence is independently 0, 1 or 2; R 6 , R 7 and R 8 are each independently H, CH 3 or CH 2 CH 3 ; provided that the heterocyclic groups within the definitions of R 1 and R 3 are independently selected from 4- to 10-membered ring systems containing one to four heteroatoms independently selected from O, N and S.