Patent ID: 7928082

Claim:
A method for treating an endocrine-regulated cancer in a subject suffering from the endocrine-regulated cancer, comprising the step of administering to the subject a bispecific antisense oligonucleotide in an amount effective to reduce the effective levels of IGFBP-2 and/or IGFBP-5 in cells of the endocrine-regulated cancer, wherein substantially all of the bispecific antisense oligonucleotide is complementary to a portion of the gene encoding human IGFBP-2 and substantially all of the bispecific antisense oligonucleotide is also complementary to the gene encoding human IGFBP-5, and wherein the bispecific antisense oligonucleotide is of sufficient length to act as an antisense inhibitor of human IGFBP-2 and human IGFBP-5, wherein the endocrine-regulated cancer is prostate cancer, and wherein the oligonucleotide consists of the series of bases as set forth in Seq. ID. No. 5.