Patent ID: 8691816

Claim:
A compound of formula I: wherein Ar is selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R 1 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; R 2 is selected from the group consisting of halogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, cyano, nitro, CF 3 , carbamoyl, C 1 -C 6 alkylcarbamoyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 alkoxyl, and C 3 -C 6 cycloalkoxyl; R 3 is selected from the group consisting of hydroxyl, carbamoyl, C 1 -C 6 alkylcarbamoyl, sulfamoyl, C 1 -C 6 alkylsulfamoyl, C 3 -C 6 cycloalkyl, cyano, nitro, carboxyl, amino, aminomethyl, acetamido, acetamido-2-methyl, 2-methoxyacetamido, propionamido, tetrahydrofuran-2-ylmethoxy, CF 3 , carboxyl, ureido, sulfamoylamino, C 1 -C 6 alkylsulfonamido, 2-amino-2-oxoethyl, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, arylamino, heteroarylamino, C 1 -C 6 alkoxyl, C 3 -C 6 cycloalkoxyl, 1H-imidazol-2-yl, oxazol-2-yl, thiazol-2-yl, methylcarbamoyl, dimethycarbamoyl, methoxyethylcarbamoyl, hydroxyethylcarbamoyl, (dimethylamino)ethylcarbamoyl, pyridin-3-ylcarbamoyl, pyridin-4-yl-carbamoyl, 6-methoxypyridin-3-ylcarbamoyl, pyridazin-4-ylcarbamoyl, and pyrimidin-5-ylcarbamoyl; R 4 is selected from the group consisting of hydrogen, hydroxyl, halogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, cyano, nitro, carbamoyl, C 1 -C 6 alkylcarbamoyl, sulfamoyl, C 1 -C 6 alkyl sulfamoyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 alkoxyl, and C 3 -C 6 cycloalkoxyl; n is 0-3; wherein Ar excludes substituted or unsubstituted indazol-3-yl and substituted or unsubstituted 1H-pyrazolo[3,4-b]pyridyl; with the following provisos: proviso Ia: when R 3 is carboxyl, methylsulfonamido, or sulfamoyl, then Ar cannot be phenyl, substituted or unsubstituted phenyl-(C 1 -C 3 )-alkyl, or phenyl-(C 2 -C 6 )-alkenyl; and proviso Ib: when R 2 and R 3 are both methoxy, then Ar cannot be phenyl, 4-methyl-phenyl, 4-methoxy-phenyl,4-halo-phenyl, or thiophen-yl.