Patent ID: 7253187

Claim:
A compound of formula I′: or a pharmaceutically acceptable salt thereof, wherein: Sp is a 5-membered heteroaromatic ring selected from pyrrole, imidazole, pyrazole, triazole, oxazole, isoxazole, 1,3-thiazole, 1,2-thiazole, or furan, wherein Ring A and Q′R 2′ are attached to Sp at non-adjacent positions; and wherein Sp has up to two R 6 substituents, provided that two substitutable carbon ring atoms in Sp are not simultaneously substituted by R 6 ; Z 1 is CH and Z 2 is CH; T is a linker group selected from —NH—, —CH 2 —, —CO—, or a saturated or unsaturated C 1-6 alkylidene chain which is optionally substituted, and wherein up to two saturated carbons of the chain are optionally replaced by —C(O)—, —C(O)C(O)—, —CONR 7 —, —CONR 7 NR 7 —, —CO 2 —, —OC(O)—, —NR 7 CO 2 —, —O—, —NR 7 CONR 7 —, —OC(O)NR 7 —, —NR 7 NR 7 —, —NR 7 CO—, —S—, —SO—, —SO 2 —, —NR 7 —, —SO 2 NR 7 —, or —NR 7 SO 2 —; Q′ is selected from —CO 2 —, —C(O)NR 7 — or —SO 2 NR 7 —; U is selected from —NR 7 —, —NR 7 CO—, —NR 7 CONR 7 —, —NR 7 CO 2 —, —O—, —CONR 7 —, —CO—, —CO 2 —, —OC(O)—, —NR 7 SO 2 —, —SO 2 NR 7 —, —NR 7 SO 2 NR 7 —, or —SO 2 —; m and n are each independently selected from zero or one; R 1 is selected from hydrogen, CN, halogen, R, N(R 7 ) 2 , OR, or OH; R 2′ is selected from —(CH 2 ) y CH(R 5 ) 2 or —(CH 2 ) y CH(R 8 )CH(R 5 ) 2 ; y is 0–6; R 3 is selected from R 7 , R, —(CH 2 ) y CH(R 8 )R, CN, —(CH 2 ) y CH(R 8 )CH(R 5 ) 2 , or —(CH 2 ) y CH(R 8 )N(R 4 ) 2 ; each R is independently selected from an optionally substituted group selected from C 1-6 aliphatic, C 6-10 aryl, a heteroaryl ring having 5–10 ring atoms, or a heterocyclyl ring having 3–10 ring atoms; each R 4 is independently selected from R, R 7 , —COR 7 , —CO 2 R, —CON(R 7 ) 2 , —SO 2 R 7 , —(CH 2 ) y R 5 , or —(CH 2 ) y CH(R 5 ) 2 ; each R 5 is independently selected from R, OR, CO 2 R, (CH 2 ) y N(R 7 ) 2 , N(R 7 ) 2 , OR 7 , SR 7 , NR 7 COR 7 , NR 7 CON(R 7 ) 2 , CON(R 7 ) 2 , SO 2 R 7 , NR 7 SO 2 R 7 , COR 7 , CN, or SO 2 N(R 7 ) 2 ; each R 6 is independently selected from R 7 , F, Cl, OR 7 , SR 7 , NR 7 COR 7 , NR 7 CON(R 7 ) 2 ; CON(R 7 ) 2 , SO 2 R 7 , NR 7 SO 2 R 7 , COR 7 , CN, or SO 2 N(R 7 ) 2 ; each R 7 is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or two R 7 on the same nitrogen are taken together with the nitrogen to form a 5–8 membered heterocyclyl or heteroaryl ring; R 8 is selected from R, (CH 2 ) w OR 7 , (CH 2 ) w N(R 4 ) 2 , or (CH 2 ) w SR 7 ; and each w is independently selected from 0–4.