Patent ID: 8513292

Claim:
A compound of formula Ia, Ib, IIa, or IIb, or a pharmaceutically acceptable salt thereof: Where U is independently selected from: wherein: R1, R2, and R3 are independently selected from the group consisting of H, F, Cl, Br, I, —NR7R8, —(C 1 -C 6 ) substituted alkyl, —(C 3 -C 9 )cycloalkyl, —(C 3 -C 9 ) substituted cycloalkyl, —O—(C 1 -C 6 ) alkyl, —O—(C 3 -C 9 ) cycloalkyl, and —O—(C 3 -C 9 ) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl; R4, R7, and R8 are independently selected from the group consisting of H, —(C 1 -C 4 ) alkyl, and —(C 1 -C 4 ) substituted alkyl; R5 is selected from the group consisting of H, —(C 1 -C 6 ) alkyl, and —CH 2 R6; R6 is selected from the group consisting of —O—P(═O)(OH) 2 , —O—P(═O)(—OH)(—O—(C 1 -C 6 ) alkyl), —O—P(═O)(—O—(C 1 -C 6 alkyl) 2 , —O—P(═O)(—OH) (—O—(CH 2 )-phenyl), —O—P(═O)(—O—(CH 2 )-phenyl) 2 , a carboxylic acid group, an amino carboxylic acid group, and a peptide; R9 is selected from the group consisting of H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 ) substituted alkyl, —(C 3 -C 9 )cycloalkyl, —(C 3 -C 9 ) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl; Q is selected from the group consisting of aryl, heteroaryl, heterocyclyl, alkyl, substituted aryl, substituted heteroaryl, substituted heterocyclyl, and substituted alkyl; T is —CH 2 —, —C(O)—, or a bond; when T is a bond, then Y is a bond, W is bond, X is —CH 2 —, and m=1, n=0; V and Z are independently selected from the group consisting of O, S, and H 2 ; X is —CH 2 —; Y and W are independently —CH 2 —, or a bond; m is 1 or 2; n is 1 or 2.