Patent ID: 7375126

Claim:
A method of treating a disorder by inhibiting vanilloid receptor subtype 1 in a mammal, wherein the disorder is selected from the group consisting of pain, bladder overactivity, urinary incontinence, inflammatory pain, osteoarthritic pain, chronic lower pain, and migraine, comprising administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof wherein ---is absent; X 1 is CR 1 ; X 2 is N or CR 2 ; X 3 is N, NR 3 , or CR 3 ; X 4 is a bond; provided that at least one of X 2 and X 3 is N; Z 1 is O; Z 2 is NH; Ar 1 is selected from the group consisting of R 1 , R 3 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, (CF 3 ) 2 (HO)C—, R B (SO) 2 R A N—, R A O(SO) 2 —, R B O(SO) 2 —, Z A Z B N—, (Z A Z B N)alkyl, (Z A Z B N)carbonyl, (Z A Z B N)carbonylalkyl, and (Z A Z B N)sulfonyl; R 2 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, (CF 3 ) 2 (HO C—, R B (SO) 2 R A N—, R A O(SO) 2 —, R B O(SO) 2 —, Z A Z B N—, (Z A Z B N)alkyl, (Z A Z B N)alkylcarbonyl, (Z A Z B N)carbonyl, (Z A Z B N)carbonylalkyl, (Z A Z B N)sulfonyl, (Z A Z B N)C(═NH)—, (Z A Z B N)C(═NCN)NH— and (Z A Z B N)C(═NH)NH—; R 8a is hydrogen or alkyl; R 8b is absent; R 9 , R 10 , R 11 , and R 12 are each individually selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, aryl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, heteroaryl, heterocycle, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, (CF 3 ) 2 (HO)C—, R B (SO) 2 R A N—, R A O(SO) 2 —, R B O(SO) 2 —, Z A Z B N—, (Z A Z B N)alkyl, (Z A Z B N)carbonyl, (Z A Z B N)carbonylalkyl, and (Z A Z B N)sulfonyl, wherein Z A and Z B are each independently hydrogen, alkyl, alkylcarbonyl, formyl, aryl, or arylalkyl, provided that at least one of R 9 , R 10 , R 11 , or R 12 is other than hydrogen, or R 10 and R 11 taken together with the atoms to which they are attached form a cycloalkyl, cycloalkenyl, or heterocycle ring; R 13 is selected from the group consisting of alkyl, aryl, heteroaryl and halogen; R A is hydrogen or alkyl; and R B is alkyl, aryl, or arylalkyl.