Patent ID: 8492090

Claim:
A method of detecting ovarian serous papillary carcinoma in an individual, comprising the steps of: examining a tumor sample from said individual by the expression level of a group of genes consisting of PEG3, MYH11, ECM2, C7, TCF21, TGFBR3, SPARCL1, ALDH1A1, TM4SF3, ABCA8, RNASE4, ITM2A, NR1H4, PLA2G2A, APOD, CHL1, SEPP1, IGF1, SEMACAP3, GPM6A, EBAF, GSTM5, COL14A1, VWF, AOX1, MAF, PIPPIN, NR4A1, COL15A1, SFRP4, MFAP4, PDGFRA, GATM, STAR, LAMA2, FABP4, WISP2, CPE, LRRC17, FMOD, CILP, ITPR1, FGF7, CXCL12, ERG, CLECSF2, VLDLR, NTRK2, PDEIA, NY-REN-7, TENC1, HFL1, GASP, PROS1, PTGIS, ARHI, FLJ32389, DKFZP586A0522, EFEMP1, PTPRD, ABCA6, RPIB9, CPZ, RECK, LOC284244, GEM, HSD11B1, PMP22, GREB1, NID, FLJ36166, PRKAR2B, COX7A1, SDC2, DSIPI, PLA2G5, SMARCA2, PRSS11, SERPINF1, SERPINA3, CXCL12, D8S2298E, MAOB, FLRT2, DPYD, MAP3K5, ANGPTL2, MAPK10, TRPC1, HLF, DSCR1L1, FOSB, IGKC, CDKN1C, PDGFRB, SCRG1, EDNRA, DMD, PON3, FXYD1, PLCL1, DOC1, PSPHL, LMOD1, PECAM1, FLJ31737, BMP6, CG018, FBLN5, FHL1, TNXB, PBX3, PLCL2, TLR5, GAS1, SGCE, EMILIN1, GNG11, MAPRE2, HMOX1, APOA1, C1R, FBN1, MEF2C, TM4SF10, AOC3, TNA, RHOBTB1, SPG20, COL16A1, CHN2, ZFHX1B, CDH11, C1S, PPP1R12B, HOP, ZNF288, F10, GPRK5, and DAB2; and performing hierarchical cluster analysis on the expression levels of said genes as compared to those in an individual that does not have ovarian serous papillary carcinoma, wherein down-regulation of said genes indicates that said individual has ovarian serous papillary carcinoma.