Patent ID: 7728020

Claim:
A compound of formula I wherein R 1 is C 1-6 -alkyl optionally substituted by OH, C 1-2 -alkoxy or 1-to-6 fluorine atoms; C 2-6 -alkenyl; or C 2-6 -alkynyl; R 2 is a radical of formula a or b where R 6 is C 1-12 -alkyl optionally substituted by halogen, by an optionally-substituted cycloalkyl, by an optionally-substituted phenyl, by an optionally-substituted heteroaryl, or by an optionally-substituted heterocyclic residue, wherein the C 1-12 -alkyl optionally is interrupted by one or more O or C═O; and wherein the phenyl, heteroaryl, cycloalkyl, and/or heterocyclic residue may be substituted by 1-to-5 substituents independently selected from hydroxy; halogen; C 1-4 -alkyl; C 1-4 -alkyl substituted by 1-to-5 fluorine atoms; C 1-4 -alkoxy; C 1-4 -alkoxy substituted by 1-to-5 fluorine atoms; cyano; phenyl; and phenyl substituted by 1-to-5 substituents independently selected from hydroxy, halogen, C 1-4 -alkyl, C 1-4 -alkoxy, and cyano; R 7 is H, optionally-substituted phenyl, optionally-substituted heteroaryl, wherein the phenyl and/or heteroaryl, independently, may be substituted by 1-to-5 substituents independently selected from hydroxy; halogen; C 1-4 -alkyl; C 1-4 -alkyl substituted by 1-to-5 fluorine atoms; C 1-4 -alkoxy; C 1-4 -alkoxy substituted by 1-to-5 fluorine atoms; and cyano; and X is O; R 3 is -A-B—COOH, where each of A and B, independently, is a bond, C═O or CDE, wherein each of D and E, independently, is H, halogen, C 1-3 -alkyl or OH; with the proviso that A and B are not both C═O; and each of R 4 and R 5 , independently, is H, C 1-4 -alkyl optionally substituted by 1, 2 or 3 halogen atoms, or acyl, where acyl is a residue W—CO, wherein W is C 1-6 -alkyl, C 3-4 -cycloalkyl, phenyl or phenylC 1-4 -alkyl; with the proviso that when R 4 is H, R 5 is H, R 3 is COOH, R 2 is a radical of formula a and R 7 is H, and either i) R 1 is CH 2 OH and XR 6 is an unsubstituted C 1-12 -alkyl that is not para to (CH 2 ) 2 —CR 1 R 3 (NR 4 R 5 ); or ii) R 1 is CH 3 and XR 6 is an unsubstituted OC 1-12 -alkyl that is not meta to (CH 2 ) 2 —CR 1 R 3 (NR 4 R 5 ); where heteroaryl is pyridyl, pyrimidinyl, pyrazinyl, furyl, oxazolyl, isoxazolyl, thiophenyl, thialzolyl, isothiazolyl, pyrrolyl, imidazolyl or pyrazolyl; cycloalkyl is C 3-6 -cycloalkyl; and a heterocyclic residue is tetrahydrofuryl, tetrahydropyranyl, aziridinyl, piperidinyl, pyrrolidinyl or piperazinyl; in free form or in salt form.