Patent ID: 8420679

Claim:
A method of modulation of the action of corticotropin releasing factor, which comprises administering to a patient in need of such modulation a therapeutically effective amount of a compound of formula (I): wherein R 1 and R 2 , which may be identical or different, each independently represent a halogen atom; a hydroxy (C 1 -C 5 )alkyl; a (C 1 -C 5 )alkyl; an aralkyl in which the aryl portion is (C 6 -C 8 ) and the alkyl portion is (C 1 -C 4 ); a (C 1 -C 5 )alkoxy; a trifluoromethyl group; a nitro group; a nitrile group; a group —SR in which R represents hydrogen, a (C 1 -C 5 )alkyl or an aralkyl in which the aryl portion is (C 6 -C 8 ) and the alkyl portion is (C 1 -C 4 ); a group —S—CO—R in which R represents a (C 1 -C 5 )alkyl or an aralkyl radical in which the aryl portion is (C 6 -C 8 ) and the alkyl portion is (C 1 -C 4 ); a group —COORa in which Ra represents hydrogen or a (C 1 -C 5 )alkyl; a group —CONRaRb with Ra and Rb as defined above for Ra; a group —NRaRb with Ra and Rb as defined above for Ra; a group —CONRcRd or —NRcRd in which Rc and Rd constitute, with the nitrogen atom to which they are attached, a 5- to 7-membered heterocycle; or a group —NHCO—NRaRb with Ra and Rb as defined above for Ra; R 3 represents hydrogen or is as defined above for R 1 and R 2 ; or alternatively R 2 constitutes with R 3 , when the latter substitutes the phenyl in position 5, a group —X—CH 2 —X— in which X independently represents a CH 2 or an oxygen or sulphur atom; R 4 represents hydrogen, a (C 1 -C 5 )alkyl; a hydroxymethyl group; a formyl group; a halogen atom; or a (C 3 -C 5 )cycloalkyl group; R 5 represents an alkynyl of 3 to 6 carbon atoms; R 6 represents a (C 1 -C 6 )alkyl; a (C 1 -C 6 )alkoxy(C 1 -C 3 )alkyl; a (C 3 -C 5 )cycloalkyl; a (C 3 -C 6 )cycloalkyl(C 1 -C 6 )alkyl; a (C 1 -C 6 )alkylthio(C 1 -C 3 )alkyl; a (C 1 -C 6 )alkylsulphoxy(C 1 -C 3 )alkyl; or a (C 1 -C 6 )alkylsulphodioxy(C 1 -C 3 )alkyl; and R 7 represents a phenyl which is unsubstituted, mono-, di- or trisubstituted in position 3, 4 or 5 with a halogen, with a (C 1 -C 5 )alkyl, with an —O—CH 2 —O— group on two neighbouring carbon atoms of the phenyl, with a —CF 3 , —NO 2 or —CN, with a group —COOR 8 or —CONR 8 R 9 or with a group —CH 2 OR 8 in which R 8 and R 9 represent a (C 1 -C 3 )alkyl, OR 10 in which R 10 represents a (C 1 -C 5 )alkyl; or alternatively R 7 represents a pyridyl, thiophene, pyrazolyl, imidazolyl, (C 3 -C 5 )cycloalkyl or (C 3 -C 6 )cycloalkyl(C 1 -C 6 )alkyl group; or an acid or base addition salt thereof.