Patent ID: 8648096

Claim:
A compound having a structure of formula (II): or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein: *denotes chiral center; X is C═O; R is (C 1 -C 6 )alkyl; (C 1 -C 6 )alkoxy; amino; (C 1 -C 6 )alkyl-amino; dialkylamino, wherein each of the alkyl groups is independently (C 1 -C 6 )alkyl; (C 0 -C 4 )alkyl-(C 6 -C 10 )aryl, optionally substituted with one or more (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or halogen; 5 to 10 membered heteroaryl, optionally substituted with one or more (C 1 -C 6 )alkyl; —NHR′; or (C 0 -C 8 )alkyl-N(R″) 2 ; R′ is: (C 1 -C 6 )alkyl; (C 0 -C 4 )alkyl-(C 6 -C 10 )aryl, optionally substituted with one or more of: (C 1 -C 6 )alkyl, said alkyl itself optionally substituted with one or more halogen, (C 1 -C 6 )alkoxy, said alkoxy itself optionally substituted with one or more halogen, (C 1 -C 6 )alkylenedioxy, or halogen; or 5 to 10 membered heteroaryl, optionally substituted with one or more (C 1 -C 6 )alkyl; and each occurrence of R″ is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, benzyl, (C 6 -C 10 )aryl, 5 to 10 membered heteroaryl, or (C 0 - C 8 )alkyl-C(O)O—(C 1 -C 8 )alkyl.