Patent ID: 7687515

Claim:
A 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivative having the general Formula I wherein R is an optional ortho- or meta-substituent selected from halogen and (C 1-4 )alkyloxy; R 1 is (C 1-4 )alkyl, (C 1-4 )alkyloxy, halogen or CF 3 ; R 2 is H, (C 1-4 )alkyl, (C 1-4 )alkyloxy or halogen; R 3 is H or (CH 2 ) n —NR 5 R 6 ; R 4 is H or (C 1-6 )alkyl, optionally substituted with COOR 7 or NR 8 R 9 ; R 5 and R 6 are independently H, (C 3-8 )cycloalkyl, quinuclidin-3-yl, (C 2-6 )alkenyl or (C 1-6 )alkyl, optionally substituted with halogen, CF 3 , (C 3-8 )cycloalkyl, (C 6-10 )aryl, a 5- or 6-membered heteroaryl group, OH, (C 1-6 )alkyloxy, (C 6-10 )aryloxy, COOR 10 , CONR 11 ,R 12 , NR 13 R 14 or NR 13 SO 2 (C 1-4 )alkyl; or R 5 and R 6 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising 1 or more heteroatoms selected from O, S, SO 2 and NR 15 , the ring being optionalily substituted with oxo, (C 1-4 )alkyl, (C 3-8 )cycloalkyl, NR 16 ,R 17 or CONR 18 ,R 19 ; R 7 is H or (C 1-4 )alkyl; R 8 and R 9 are independently H, (C 1-4 )alkyl (optionally substituted with di(C 1-4 )alkylamino) or (C 3-8 )cycloalkyl; or R 8 and R 9 form together with the nitrogen to which they are bound a 4-8-membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; R 10 is H or (C 1-4 )alkyl; 11 and R 12 are independently H or (C 1-4 )alkyl; or R 11 and R 12 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; R 13 and R 14 are independently H or (C 1-4 )alkyl; or R 13 and R 14 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; R 15 is H, (C 1-4 )alkyl (optionally substituted with OH, (C 1-4 )alkyloxy, di(C 1-4 )alkylamino, or CONR 21 ,R 22 ), phenyl, pyridyl, COR 20 or CONR 21 ,R 22 ; R 16 and R 17 are independently H or (C 1-4 )alkyl; or R 16 and R 17 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; R 18 and R 19 are independently H or (C 1-4 )alkyl; R 20 is H, (C 1-4 )alkyl, (C 3-8 )cycloalkyl, (C 1-4 )alkyloxy or furyl; R 21 and R 22 are independently H or (C 1-4 )alkyl; or R 21 and R 22 together with the nitrogen to which they are bound form a 4-8 membered saturated heterocyclic ring, optionally further comprising a heteroatom selected from O and S; and n is 0 or 1; or a pharmaceutically acceptable salt thereof.