Patent ID: 8575221

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein: R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of —OH, —O(C 1 -C 6 alkyl), —NO 2 , —NH 2 , —NH(C 1 -C 6 alkyl) and —N(C 1 -C 6 alkyl) 2 , wherein each C 1 -C 6 alkyl is optionally and independently substituted with one or more deuterium; R 5 and R 6 are each independently hydrogen, deuterium, halo, or —NO 2 ; R 7 is hydrogen, deuterium, or —R 13 ; R 13 is (C 2 -C 6 ) alkenyl optionally substituted with one or more deuterium and substituted with —C(O)R 12 ; R 12 is —OCH 3 , —OCH 2 CH 3 , —NH(CH 2 CH 3 ), —CN, or —CH 2 OH, wherein each of —OCH 3 , —OCH 2 CH 3 , —NH(CH 2 CH 3 ), and —CH 2 OH is optionally substituted with one or more deuterium; R 8 and R 11 are each independently hydrogen or deuterium; R 9 and R 10 are each independently hydrogen or deuterium; X 1 and X 2 are each independently CH, CD, C(OCH 3 ), C(OCD 3 ) or C(NO 2 ); provided that at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 11 , R 9 , R 10 , X 1 and X 2 comprises deuterium; and provided that the compound of Formula I is not