Patent ID: 8236329

Claim:
A composition comprising micelles encapsulating three drugs, wherein the micelles comprise poly(ethylene glycol)-block-poly(lactic acid) polymers; the hydrophobic poly(lactic acid) block of the polymers orient toward the interior of each micelle, and the hydrophilic poly(ethylene glycol) block of the polymers orient toward the exterior of each micelle; the molecular weight of the poly(ethylene glycol) block is about 1,000 to about 35,000 g/mol and the molecular weight of the poly(lactic acid) block is about 1,000 to about 15,000 g/mol; the drug loading of the micelles is about 1 wt. % to about 50 wt. % with respect to the mass of the micelles; the three drugs are non-covalently encapsulated in the interior of the micelles; the three drugs are paclitaxel, 17-AAG, and rapamycin; docetaxel, 17-AAG, and rapamycin; or paclitaxel, etoposide, and 17-AAG; and the composition is substantially free of ethanol, dimethyl sulfoxide, castor oil, and castor oil derivatives.