Patent ID: 8614198

Claim:
A method for silencing an hepatitis C virus (HCV) RNA in a mammalian cell comprising administering to said cell at least four double-stranded RNA effector molecules or complexes, comprising: (a) (1) sequences of at least 19 consecutive nucleotides having at least 90% identity with a nucleotide sequence of SEQ ID NO: 9, SEQ ID NO: 33, SEQ ID NO: 31, and SEQ ID NO: 11; and (2) their complementary sequences; (b) (1) sequences of at least 19 nucleotides having at least 90% identity with a nucleotide sequence of SEQ ID NO: 19, SEQ ID NO: 33, SEQ ID NO: 31, and SEQ ID NO: 11; and (2) their complementary sequences; or (c) (1) sequences of at least 19 nucleotides having at least 90% identity with a nucleotide sequence of SEQ ID NO: 26, SEQ ID NO: 32, SEQ ID NO: 31, and SEQ ID NO: 33; and (2) their complementary sequences.