Patent ID: 8178528

Claim:
A compound structurally represented by Formula I or a pharmaceutically acceptable salt thereof, wherein: Y independently represents carbon; X independently represents carbon or nitrogen; R1 is independently —CN, —NO 2 , —(C 1 -C 7 ) alkyl(optionally substituted with 1 to 3 halogens), —(C 3 -C 8 ) cycloalkyl, —(C 1 -C 7 ) alkyl-S(O) 2 —(C 1 -C 3 ) alkyl, —(C 1 -C 7 ) alkyl-C(O)—O—R3, —(C 1 -C 7 ) alkyl-S(O) 2 -phenyl substituted three times with R2, —(C 1 -C 7 ) alkyl-S—(C 1 -C 7 ) alkyl, —(C 1 - C 7 ) alkyl-(C 3 -C 8 ) cycloalkyl, —(C 1 -C 7 ) alkyl-phenyl substituted three times with R2, —C(O)-phenyl substituted three times with R2, —C(O)—(C 1 -C 7 ) alkyl, —C(O)—(C 3 -C 8 ) cycloalkyl, —(C 1 -C 7 ) alkyl-C(O)-phenyl substituted three times with R2, —S—(C 1 -C 7 ) alkyl, —S—(C 1 -C 7 ) alkyl-phenyl substituted three times with R2, —S—(C 3 -C 8 ) cycloalkyl-(C 1 -C 7 ) alkyl, —S—(C 3 -C 8 ) cycloalkyl, —S—(C 2 -C 7 ) alkenyl, —S-phenyl substituted three times with R2, —SO 2 -phenyl substituted three times with R2, —SO 2 R7, —S(O)R7, —(C 2 -C 7 ) alkenyl, —(C 3 -C 8 ) cycloalkenyl, —(C 2 -C 7 ) alkenyl-S (O) 2 —(C 1 -C 3 ) alkyl, —(C 2 -C 7 ) alkenyl-C(O)—O—R3, —(C 2 -C 7 ) alkenyl-S(O) 2 -phenyl substituted three times with R2, —(C 2 -C 7 ) alkenyl-S—(C 1 -C 7 ) alkyl, —(C 2 -C 7 ) alkenyl-(C 3 -C 8 ) cycloalkyl, or —(C 2 -C 7 ) alkenyl-phenyl substituted three times with R2; R2 is independently at each occurrence —H, -halogen, —(C 1 -C 7 ) alkyl(optionally substituted with 1 to 3 halogens), —C(O)R7, —C(O)OR7, —C(O)(C 3 -C 8 )cycloalkyl, —OCF 3 , —OR7, —SR7, —SO 2 R7, —SO 2 CF 3 , or —S(O)R7; R3 is independently at each occurrence —H, or —(C 1 -C 3 ) alkyl(optionally substituted with 1 to 3 halogens); R4 and R5 are independently at each occurrence —H, —(C 1 -C 3 ) alkyl(optionally substituted with 1 to 3 halogens), or —OR3, provided that when X is nitrogen, then R4 or R5 are not attached to X; R6 is independently at each occurrence —H, -halogen, —CF 3 , —(C 1 -C 3 ) alkyl(optionally substituted with 1 to 3 halogens), or —OR3; and R7 is independently at each occurrence —H, —(C 1 -C 7 ) alkyl(optionally substituted with 1 to 3 halogens), or —(C 2 -C 7 ) alkenyl.