Patent ID: 8080542

Claim:
A compound having the formula or a pharmaceutically-acceptable salt thereof, wherein: A is phenyl substituted with 0, 1, 2 or 3 substituents selected from F, Cl, Br, OC 1-4 alk, C 1-4 alk, and C 1-4 haloalk; B is phenyl substituted with 0, 1, 2 or 3 substituents selected from F, Cl, Br, OC 1-4 alk, C 1-4 -alk, and C 1-4 haloalk; L is —C≡C—, —CH 2 CH 2 —, —N(R a )C(═O)— or —C(═O)N(R a )—; R a is, independently in each instance, H or C 1-6 alk; R 1 is selected from C 1-6 alk, OC 1-5 alk, N(R a )C 1-5 alk, N(C 1-5 alk)C 1-5 alk, aryl and heteroaryl; X is selected from WC(═O)OR 6a , WP(═O)R 6b R 6c , WS(═O) 2 OH, WCONHSO 3 H and 1H-tetrazol-5-yl; W is a direct bond, oxygen or C 1-4 alk having one or more substituents independently selected from halogen, OH, cyano, NR a R a , arylamino, heteroarylamino, OC 1-4 alk and CO 2 H; R 6a is hydrogen or C 1-4 alk; R 6b and R 6c are independently hydrogen, OH, C 1-4 alk or C 1-4 haloalk; Y is residue of formula (a) wherein the left and right asterisks indicate the point of attachment wherein the N, designated by the left asterisk, is attached to Z 1 , and the carbon, designated by the right asterisk, is attached to X, wherein Q is selected from a direct bond, C═O, C═S, SO 2 , C═ONR a and (CR 10 R 11 ) m ; m is 0, 1, 2 or 3; R 7 and R 8 together with the atoms to which they are attached form a 4- to 7-membered ring optionally containing an additional heteroatom selected from N, O and S; R 9 is selected from hydrogen, halogen, OH, cyano, C 1-6 alk, SC 1-5 alk, OC 1-5 alk, C 1-6 haloalk and OC 1-5 haloalk; R 10 and R 11 are independently selected from hydrogen, halogen, OH, cyano, C 1-6 alk, OC 1-5 alk, SC 1-5 alk, C 1-6 haloalk and OC 1-5 haloalk; Z 2 is selected from O, NR 3 , S, S(═O), S(═O) 2 , (CR 4 R 5 ) n , C═O, C═S, C═N—R 3 , and a direct bond, wherein n is 0, 1, 2 or 3; Z 1 is selected from O, NR 3 , S, S(═O), S(═O) 2 NR 3 , (CR 4 R 5 ) n , C═O, C═S, and C═N—R 3 , wherein n is 1, 2 or 3; R 3 is selected from hydrogen, OH, SO 2 , C═O, C═S, C═NH, C 1-6 alk, OC 1-5 alk, SC 1-5 alk, C 1-6 haloalk, OC 1-5 haloalk, aryl and heteroaryl; or when Z 2 is a direct bond, R 3 is a C 3 -C 6 ring optionally containing a heteroatom; and R 4 and R 5 are independently selected from hydrogen, halogen, OH, cyano, C 1-6 alk, OC 1-5 alk, SC 1-5 alk, C 1-6 haloalk, OC 1-5 haloalk, aryl and heteroaryl, or R 4 and R 5 together with the carbon atom to which they are attached form C═O.