Patent ID: 7825246

Claim:
A compound having the structure (B): wherein: X is selected from a group consisting of a bond, O, C═O, SO 2 , and CH 2 ; Y is selected from a group consisting of a bond and NR 9 ; or X and Y taken together is a bond; R 9 is selected from a group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 branched alkyl, C 1 -C 6 aminoalkyl, and C 1 -C 6 hydroxyalkyl; each of R 1 is independently selected from a group consisting of H, C 1 -C 6 alkyl, cycloalkyl, and heterocycle; each of n, or p is independently an integer having the value between 0 and 6; Q 1 is a 4-7 membered heterocycle connected through carbon or nitrogen, with one or more heteroatoms in the heterocyle, and each carbon or nitrogen in the heterocycle is optionally substituted independently with C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl or aminoalkyl, C 1 -C 6 branched alkyl, C 1 -C 6 cycloalkyl, aryl connected through carbon or a heteroatom, a halogen, CF 3 , —OCF 3 , NO 2 , CN, OH, CONR 3 R 4 , and COR 3 ; each of R 6 , R 7 , R 8 is independently selected from a group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl or aminoalkyl, C 1 -C 6 branched alkyl, C 1 -C 6 cycloalkyl, aryl, C 1 -C 6 alkoxy, a halogen, CF 3 , —OCF 3 , CHR 3 R 4 , SR 3 , SOR 3 , SO 2 R 3 , SO 2 NR 3 R 4 , SO 3 R 3 , POR 3 , PO 2 R 3 , PO 2 NR 3 R 4 , PO 2 CR 3 R 4 , PO 3 R 3 , NR 3 R 4 , NO 2 , CN, OH, CONR 3 R 4 , COR 3 , COOR 3 , NR 3 COR 4 , NR 3 CONR 3 R 4 , OCONR 3 R 4 , CSNR 3 R 4 , CSR 3 , NR 3 CSNR 3 R 4 , SCONR 3 R 4 , and SCSNR 3 R 4 ; or any of R 6 and R 7 taken together, or R 7 and R 8 taken together, or R 6 and R 8 taken together form a moiety independently selected from a group consisting of —HN—CH═CH—, —HN—N═CH—, —HN—N═N—, —O(CH 2 ) n O—, —S(CH 2 ) n S—, —N═CH—S—, —CH═N—O—, —CH═N—S—, —N═CH—O—, —C═N—O—, —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —O—CH═CH—, and —S—CH═CH—; each of R 3 and R 4 is independently selected from a group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl or aminoalkyl, and C 1 -C 6 branched alkyl, with the further provisos that: (a) at least one of R 6 , R 7 and R 8 is not hydrogen; (b) R 6 and R 7 , or R 6 and R 8 , or R 7 and R 8 are substituted with non-hydrogen atoms, or if only one of R 6 , R 7 and R 8 is substituted, then the substitution contains at least three non-hydrogen atoms; (c) any one of R 6 , R 7 or R 8 optionally comprises a heteroatom selected from a group consisting of O, N and S; and (d) the moiety Q 1 excludes hetero-aromatic cyclic rings, or a pharmaceutically acceptable salt, or an individual diastereomer of the compound (B).