Patent ID: 7632528

Claim:
A method of treatment to reduce at least one of frequency and severity of migraine, comprising administering a synergistic composition containing extracts of Sapindus trifoliatus and Emblica officinalis in combination with selected pharmaceutically acceptable additives in the form of nasal drops, wherein the synergistic composition comprises: i. aqueous extract of pericarp of Sapindus trifoliatus in an amount of 0.1% to 1.0% w/v; ii. aqueous extract of dried fruit of Emblica officinalis in an amount of 0.1 to 1% w/v; iii. pharmaceutically acceptable additives selected from a) astringent in an amount of 0.1% w/v to 0.6% w/v, b) suspending agent in an amount of 0.1% to 3% w/v; c) isotonic agent in an amount of 0.85 to 0.90% w/v, d) preservative in an amount of 0.1% w/v to 1% w/v, e) sequestering agent in an amount of 0.05 to 0.2% w/v, f) antioxidant in an amount of 0.02 to 0.08% w/v. and g) pH adjusting agent in sufficient amount, said composition having a pH of 3.5 to 7.0.