Patent ID: 6890921

Claim:
A compound of Formula I wherein: A is (CH 2 ) n where n is 1-6; R 1 is C 1-6 alkyl; phenyl; substituted phenyl where the phenyl substituents are independently selected from one or more of the group consisting of C 1-5 alkyl, C 1-5 alkoxy and halogens; phenylC 1-5 alkyl; or substituted phenylC 1-5 alkyl where the phenyl substituents are independently selected from one or more of the group consisting of C 1-5 alkyl, C 1-5 alkoxy and halogen; R 2 is hydrogen, C 1-6 alkyl, C 2-5 alkenyl, C 2-5 alkynyl, phenylC 1-5 alkyl, or substituted phenylC 1-5 alkyl where the phenyl substituents are independently selected from one or more of the group consisting of C 1-5 alkyl, C 1-5 alkoxy and halogen; E is where: m is 1-5; R 3 is hydrogen, C 1-6 alkyl or oxygen, where if R 3 is oxygen, the dashed line represents a bond and if R 3 is C 1-6 alkyl the dashed line is absent; R 4 is oxygen, hydrogen, C 1-5 alkyl, formyl, carboxy, C 1-5 alkylcarbonyl, C 1-5 alkoxycarbonyl, phenyC 1-5 alkoxy, substituted phenylC 1-5 alkoxy where the phenyl substituents are independently selected from one or more of the group consisting of C 1-5 alkyl, C 1-5 alkoxy and halogen, carbamoyl and substitued carbamoyl where the nitrogen substituents are independently selected from one or more of the groups consisting of hydrogen C 1-5 alkyl, C 1-5 alkoxy and hydroxy, where if R 4 is oxygen, the dashed line represents a bond and if R 4 is any other substituent, the dashed line is absent; R 5 is hydrogen, C 1-5 alkyl or taken together with R 6 to form a cyclohexane, cyclopentane or cyclopropane ring; R 6 is hydrogen, C 1-5 alkyl or taken together with R 5 to form a cyclohexane, cyclopentane or cyclopropane ring; or pharmaceutically acceptable salts thereof.