Patent ID: 8663658

Claim:
A solid dispersion comprising particles of revaprazan, wherein the revaprazan particles are in a crystalline form and are surface-modified with a water-soluble polymer, a water-soluble saccharide, a surfactant, or a mixture thereof, wherein the water-soluble polymer is selected from the group consisting of polyvinylpyrrolidone, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, polyethylene glycol, a water-soluble polyacrylic acid copolymer, polyvinyl alcohol, and a mixture thereof; wherein the water-soluble saccharide is selected from the group consisting of lactose, white sugar, sucrose, mannitol, sorbitol, xylitol, trehalose, maltitol, dulcitol, inositol, dextrin, cyclodextrin, and a mixture thereof; and wherein the surfactant is selected from the group consisting of sorbitan ester or polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyethylene glycol-15-hydroxystearate, polyoxyethylene glycolated natural or hydrogenated castor oil, polyoxyethylene-polyoxypropylene copolymer, synthetic vitamin E derivative, polyoxyethylene alkyl ester, fatty acid microgol glyceride, polyglyceryl fatty acid ester, bile acid, sodium lauryl sulfate, lecithin, glyceryl fatty acid ester, polyoxyethylene stearate, and a mixture thereof.