Patent ID: 8722882

Claim:
A compound having the formula: or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein: R 1 is H, alkyl, halo or —O-alkyl; R 2a is H or alkyl, or R 2a and R 2b join to form —CH 2 CH 2 —, —CH 2 CH 2 CH 2 — or —CH 2 OCH 2 —; R 2b is H or alkyl; R 3a is H or alkyl, or R 3a and R 3b join to form —CH 2 CH 2 —, —CH 2 CH 2 CH 2 — or —CH 2 OCH 2 —; R 3b is H or alkyl; R 4 is alkyl, cycloalkyl, haloalkyl, aryl, -alkylene-aryl or heteroaryl, wherein an aryl or heteroaryl group can be optionally substituted with one or more groups, which can be the same or different, and are selected from alkyl, halo, haloalkyl, —O-alkyl, —CN and —S(O) 2 -alkyl; R 5 is alkyl, cycloalkyl, haloalkyl, -alkylene-aryl, alkenyl or —N(alkyl) 2 ; A is a bond; Q is —N—; W is —C(O)—, —C(O)O—, or —S(O) 2 —; Y is —O—, —S—, or —NH—; Z is —CH—; each occurrence of n is independently 0, 1 or 2; and each occurrence of p is 1.