Patent ID: 8722854

Claim:
Process for the preparation of crosslinked collagen matrices, comprising the steps: a) preparing an aqueous collagen suspension, b) adjusting the pH value of the collagen suspension from step a) to pH<4, c) optionally adding at least one of structure-forming agents, active ingredients and auxiliary substances, d) adding an epoxy-functional crosslinking agent in an amount of not more than 50 wt. % based on the dry mass of the collagen suspension from step a), the order of steps c) and d) being variable, e) freezing the collagen mixture obtainable from step d), f) freeze-drying of the frozen mixture from step e) at a freeze-drying temperature<100° C., g) adjusting the freeze-dried crosslinked collagen material so obtained to a moisture content of from 3 to 25 wt. %, based on the end product, and h) optionally converting the materials obtainable from step g) into a desired form to afford formed materials, and i) at least one of sterilizing and processing the formed materials.