Patent ID: 7875627

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein - - - is absent or a covalent bond; X 1 is CR 1 ; X 2 is CR 2 ; X 3 is N; X 4 is selected from CR 4 ; X 5 is selected from N and CH 2 ; provided that at least one of X 1 , X 2 , X 3 and X 4 is N; X 6 is selected from O, NH and S; Z 1 is selected from O, NH and S; Z 2 is absent or selected from NH and O; L is selected from aryl, alkenylene, alkylene, alkynylene, cycloalkylene, heterocycle, —(CH 2 ) m O(CH 2 ) n —, —N(H)O—, and —NHNH— wherein the left end of —(CH 2 ) m O(CH 2 ) n —and —N(H)O— is attached to Z 2 and the right end is attached to R 7 ; provided that when Z 2 is NH or O then L is other than —N(H)O— or —NHNH—; m and n are each independently 1-6; R 1 , R 3 and R 5 are each independently selected from hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, amines, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, ethylenedioxy, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, methylenedioxy, mercapto, mercaptoalkyl, nitro, (CF 3 ) 2 (HO)C—, R B S(O) 2 R A N—, R A OS(O) 2 —, R B —S(O) 2 —, Z A Z B N—, (Z A Z B N)alkyl, (Z A Z B N)carbonyl, (Z A Z B N)alkylcarbonyl and (Z A Z B N)sulfonyl, wherein Z A and Z B are each independently selected from hydrogen, alkyl, alkylcarbonyl, formyl, aryl, and alkylalkyl; R 2 and R 4 are each independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, amines, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, ethylenedioxy, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, methylenedioxy, mercapto, mercaptoalkyl, nitro, (CF 3 ) 2 (HO)C—, R B S(O) 2 R A N—, R A OS(O) 2 —, R B —S(O) 2 —, Z A Z B N—, (Z A Z B N)alkyl, (Z A Z B N)carbonyl, (Z A Z B N)alkylcarbonyl, (Z A Z B N)sulfonyl, (Z A Z B N)C(═NH)—, (Z A Z B N)C(═NCN)NH—, and (Z A Z B N)C(═NH)NH—; R A is selected from hydrogen and alkyl; R B is selected from alkyl, aryl and arylalkyl; R 6 is absent or selected from hydrogen and alkyl; provided that R 6 is absent when X 5 is CH 2 and R 4 is selected from hydrogen and alkyl when X 5 is N; R 7 is selected from hydrogen, aryl and heterocycle; and provided that R7 is aryl when L is alkylene.