Patent ID: 6946485

Claim:
A method of treating a mammal suffering from or at risk of vascular injury, comprising: administering to a patient a Ras antagonist in an mount effective to treat the mammal, wherein the Ras antagonist is represented by the formula wherein: R 1 represents farnesyl, geranyl or geranyl-geranyl; Z represents C—R 6 or N; R 2 represents H, CN, the groups COOR 7 , SO 3 R 7 , CONR 7 R 8 , COOM, SO 3 M and SO 2 NR 7 R 8 , wherein R 7 and R 8 are each independently hydrogen, alkyl or alkenyl, and wherein M is a cation; R 3 , R 4 , R 5 and R 6 are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, axido, or thiocyanato; X represents O, S, SO, SO 2, NH or Se; and the quaternary ammonium salts and N-oxides of the compounds of said formula when Z is N.