Patent ID: 7713924

Claim:
A method for treating a condition associated with the excess accumulation of extracellular matrix in a tissue and/or an organ or at a dermal wound site comprising: a. reducing the excess accumulation of extracellular matrix associated with TGFβ overproduction and/or activity iii an organ or tissue, or at a wound site, by administering, in an amount sufficient to inhibit TGFβ overproduction and/or activity; at least a first agent that decreases levels of TGFβ by one biochemical pathway; and b. degrading excess accumulated extracellular matrix in said tissue and/or organ or wound site, by administering, in an amount sufficient to degrade excess accumulated extracellular matrix, a PAI-1 inhibitor, whereby the accumulation of extracellular matrix in said tissue and/or organ or wound site is reduced from the level existing at the time of treatment.