Patent ID: 8143257

Claim:
A compound of Formula (I) having the structure: wherein X is O or S; A is O or N, with the proviso that when A is O, R 3 is absent; R 1 and R 2 taken together with the atom to which they are attached, may optionally form a substituted or unsubstituted heterocycle containing, including the heteroatom to which R 1 and R 2 are attached, one to three ring heteroatoms selected from the group consisting of N, O, and S, wherein the unsubstituted heterocycle is selected from 1,2,3,4-tetrahydroisoquinoline, 3,4-dihydro-1H-isoquinoline, piperidine, morpholine, 1,2,3,4-tetrahydroquinoline, 3,4-dihydro-2H-quinoline, pyrrolidine, 2,3-dihydro-indole, indoline, piperazine, [1,4]diazepane or 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, wherein the substituted heterocycle is selected from piperidine, 1,4-diazepane or piperazine, wherein piperidine and 1,4-diazepane are substituted with methyl, hydroxy-diphenyl-methyl, benzyl, piperidine, aminocarbonyl, 4-chloro-phenyl or phenyl and, wherein piperazine is substituted with methyl, hydroxy-diphenyl-methyl, piperidine, aminocarbonyl, 4-chloro-phenyl or phenyl; R 3 is H; R 12 is H, unsubstituted alkyl, unsubstituted alkoxy and halogen; R 4 is selected from the group consisting of H, —COR 9 , —NR 10 R 11 , and halogen; wherein one of R 10 and R 11 is H and the other is unsubstituted alkylsulfonyl; and R 9 is selected from unsubstituted alkyl; or a pharmaceutically acceptable salt thereof.