Patent ID: 8679453

Claim:
A MRI, PET, CT, X-ray, SPECT, optical or ultrasound agent or composition having formula: wherein M is a metal selected from the group consisting of Gd 3+ , Eu 3+ , Tm 3+ , Dy 3+ , Tb 3+ , Yb 3+ , Mn 2+ , 111 In 3+ , 113m In 3+ , 67 Ga 3+ , 68 Ga 3+ , 99m Tc 4+ , 64 Cu 2+ , Tl 3+ , 153 Sm 3+ , 166 Ho 3+ , 212 Bi 3+ , 90 Y 3+ , 377 Lu 3+ , 225 Ac 3+ , 149 Pm, 159 Gd, 140 La, 175 Yb, 47 Sc, 186 Re, 97 Ru, 105 Rh, 109 Pd, 197 Pt, 67 Cu, 198 Au, 117m Sn, 212 Pb, Ce, Pr, Nd, Pm, Sm, Ho, Er, Lu, and Y; and wherein the agent or composition is capable of detecting a target in vivo in a subject.