Patent ID: 7157419

Claim:
A growth factor binding compound, of the general structure: wherein R is n-butyl, n-propyl, benzyl, (C 1 –C 12 ) alkyl, (C 7 –C 18 ) aralkyl, (C 6 –C 18 ) aryl, (C 1 –C 12 ) alkenyl, (C 7 –C 18 ) aralkenyl, or (C 1 –C 12 ) alkylether, and X are independently cyclic peptide loops of the general structure: wherein R 1 , R 2 , R 3 , and R 4 are each amino acid side chains that define a tetrapeptide, wherein said tetrapeptide is covalently attached at the amino and carboxy termini of said tetrapeptide to a 3-aminomethyl-5-aminobenzamide linking group, and wherein said tetrapeptide is selected from the group consisting of GDFD (SEQ ID NO. 1), GDDD (SEQ ID NO. 2), D-ADGD (SEQ ID NO. 3), GDLD (SEQ ID NO. 4), GDAD (SEQ ID NO. 5), GDGY (SEQ ID NO. 6), ADGD (SEQ ID NO. 7), GDSD (SEQ ID NO. 8), GKGF (SEQ ID NO. 9), GKGK (SEQ ID NO. 10), GDND (SEQ ID NO. 11), PDGD (SEQ ID NO. 12), GDDG (SEQ ID NO. 13), and GDDY (SEQ ID NO. 14).