Patent ID: 8512716

Claim:
A method for treating a subject having cancer, the method comprising the steps of: (a) assessing a level of Mcm2 in a biological sample from the subject; and (b) assessing a level of geminin in the biological sample from the subject, wherein the combination of the level of the Mcm2 compared to a pre-determined value and the level of the geminin compared to a predetermined value is indicative of the treatment regimen prescribed for the subject; and (c) treating the subject with a treatment regimen comprising: (i) administering one or more non-cell cycle phase-specific chemotherapeutic agents if the level of the Mcm2 compared to a pre-determined value is low and the level of the geminin compared to a pre-determined value is low; or (ii) administering one or more G1 phase-specific chemotherapeutic agents to the subject, or administering one or more non-S and non-G2/M cell cycle phase-specific chemotherapeutic agents to the subject, if the level of the Mcm2 compared to a pre-determined value is high and the level of the geminin compared to a pre-determined value is low; or (iii) conducting surgery on the subject, or administering one or more S cell cycle phase-specific chemotherapeutic agents or G2/M cell cycle phase-specific chemotherapeutic agents to the subject, if the level of the Mcm2 compared to a pre-determined value is high and the level of the geminin compared to a pre-determined value is high.