Patent ID: 7456194

Claim:
A compound of formula (I), enantiomers, diastereomers, and salts, thereof wherein X is S; R 1 is selected from hydrogen, and C 1-3 alkyl; R 2 is hydrogen or alkyl; R 3 is hydrogen; R 6 is R 6 is Z 1d , is —W 1 —V 1 ; where W 1 is alkyl; and V 1 is —U 1 —NH 2 , or —U 1 —N(Y 4 )—C(O)—Y 1 , Y 1 and Y 4 (1) are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, aryl, -heterocyclo, (heterocylco)alkyl, heteroaryl, or (heteroaryl)alkyl, where heterocyclo is selected from azetidinyl, morpholinyl, 5-oxo-2-pyrrolidinyl, piperidinyl, pyrazolyl, pyrrolidinyl, tetrahydrofuranyl, and where heteroaryl is selected from benzofuranyl, benzimidazolyl, benzotriazolyl, 1,1-dioxide-2H-thiopyranyl, furanyl, imidazolyl, indolyl, isoxazolyl, 2-oxo-1H-benzimidazolyl, pyrazinyl, pyridinyl-1-oxide, pyridinyl, pyridazinyl, pyrrolyl, thiadiazolyl, or thiazolyl, any of which may be optionally independently substituted as valence allows with one or more Z 4 , Z 5 and Z 6 ; Z 4 , Z 5 , and Z 6 are optional substituents at each occurrence independently selected from (1) H (2) alkyl, or aryl; (3) —U 1 —O—Y 5a , (4) —U 1 —S—Y 5a , (5) —U 1 —C(O) t —H, —U 1 —C(O) t —Y 5a where t is 1 or 2, (6) —U 1 —SO 3 —H, or —U 1 —S(O) t Y 5a , (7) —U 1 -halo, (8) —U 1 -cyano, (9) —U 1 -nitro, (10) —U 1 —NY 2a Y 3a , (11) —U 1 —C(O) 2 —NY 2a Y 3a , (12) —U 1 —S(O) 2 —N(Y 4a )—Y 1a , (13) oxo; Y 1a , Y 2a , Y 3a , Y 4a and Y 5a (1) are each independently hydrogen, or alkyl; U 1 is independently (1) a single bond, (2) alkylene, (3) alkenylene, or (4) alkynylene.