Patent ID: 8481510

Claim:
A compound of formula I: including any possible stereoisomers thereof, wherein: R 4 is a monophosphate, diphosphate or triphosphate ester; or R 4 is a group of formula R 7 is phenyl, optionally substituted with 1, 2, or with 3 substituents each independently selected from halo, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 1 -C 6 alkoxy, hydroxy, and amino; or R 7 is naphthyl, optionally substituted with 1, 2, or with 3 substituents each independently selected from halo, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 1 -C 6 alkoxy, hydroxy, and amino; or R 7 is indolyl, optionally substituted with one C 1 -C 6 alkyloxy-carbonyl group and optionally further with 1, 2, or with 3 substituents each independently selected from halo, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 1 -C 6 alkoxy, hydroxy, and amino; R 8 is hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; R 8′ is hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; or R 8 and R 8′ together with the carbon atom to which they are attached form C 3 -C 7 cycloalkyl; R 9 is C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl or phenyl-C 1 -C 6 alkyl, wherein the phenyl moiety in phenyl or phenyl-C 1 -C 6 alkyl is optionally substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C 1 -C 6 alkoxy, amino, mono- and diC 1 -C 6 alkylamino; or a pharmaceutically acceptable salt or solvate thereof.