Patent ID: 8603823

Claim:
An isolated host cell comprising a recombinant nucleic acid coding for a functional vitamin K epoxide reductase (VKOR), wherein the recombinant nucleic acid coding for the VKOR comprises a nucleotide sequence selected from the group consisting of: 1) a nucleotide sequence that encodes an amino acid sequence having at least 80% identity with the amino acid sequence of SEQ ID NO:10 and that encodes a VKOR; 2) a nucleotide sequence that that encodes a human VKOR; 3) a nucleotide sequence that encodes a mouse VKOR; 4) a nucleotide sequence that encodes a rat VKOR; 5) a nucleotide sequence that encodes a zebrafish VKOR; 6) a nucleotide sequence that encodes a Xenopus VKOR; and 7) a nucleotide sequence that encodes an Anopheles VKOR, and a recombinant nucleic acid coding for a vitamin K dependent protein, wherein both the recombinant VKOR and the recombinant Vitamin K dependent protein are expressed in said host cell.