Patent ID: 7998463

Claim:
A method for treatment of cough, tussive attacks or tussive episodes by a targeted delivery of a local anesthetic to trachea, carina, and bronchi of a patient in need thereof without co-administering a bronchodilator, said method comprising steps: a) preparing an inhalable dry powder consisting essentially of about 10 to about 80 mg of said local anesthetic selected from the group consisting of proparacaine, cocaine, procaine, tetracaine, hexylcaine, bupivacaine, lidocaine, benoxinate, mepivacaine, prilocalne, mexiletene, vadocaine and etidocaine; and an excipient selected from the group consisting of lactose, lysine and leucine; b) selecting dry powder inhaler or meter dose inhaler able to generate aerosol of particle sizes substantially between 3.0 and 10 μm; c) nebulizing said inhalable dry powder into an aerosol, wherein at least 80% of the particles have a mass median aerodynamic diameter between about 3 and 10 μm and a geometric standard deviation lower than 1.7; and d) administering said aerosol to said patient once, twice or several times a day; wherein said administration results in deposition of said local anesthetic in trachea, carina, and bronchi for treatment of cough or tussive attacks or episodes; without cousin bronchospasm loss of gag reflex, oropharyngeal numbing, or systemic circulation of said local anesthetic.