Patent ID: 7718362

Claim:
A method for medium resolution typing of a target human leukocyte antigen (HLA) gene comprising: a) isolating a target leukocyte cell comprising a target HLA gene from a suitable sample and obtaining a preparation comprising a target HLA nucleotide sequence that is at least a part of said target HLA gene from said isolated target leukocyte cell and, optionally another nucleotide sequence not related to said target HLA gene; b) providing a chip comprising a support suitable for use in nucleic acid hybridization having immobilized thereon: a set of oligonucleotide probes complementary to said target HLA nucleotide sequence, each of said probes having 30 nucleotides or less, wherein said set of oligonucleotide probes comprises SEQ ID NOS: 1-214 or the complement of SEQ ID NOS: 1-214; and at least one of each of the following oligonucleotide control probes: a positive control probe, a negative control probe, a hybridization control probe and an immobilization control probe; and c) hybridizing said preparation obtained in step a) to said chip provided in step b) and assessing hybridization between said target HLA nucleotide sequence and/or said another nucleotide sequence and said probe comprised on said chip to determine the type of said target HLA gene.