Patent ID: 7431927

Claim:
A monoclonal antibody comprising: a) a variable domain comprising: i. a heavy cahin varable domain comprising a CDR1 region identical to amino acid residues 30-34 of SEQ ID NO: 31, a CDR2 region identical to amino acid residues 49-64 of SEQ ID NO: 31 and a CDR3 region identical to amino acid 97-109 of SEQ ID NO: 31; and ii. a light chain variable domain comprising a CDR1 region identical to amino acid residues 23-33 of SEQ ID NO: 75, a CDR2 region identical to amino acid residues 49-55 of SEQ ID NO: 75 and a CDR3 region identical to amino acid residues 88-99 of SEQ ID NO: 75; or b) a variant of said variable domain of part a) that is otherwise identical to said variable domain except for up to 4 amino acid substitutions in said CDR regions; wherein said monoclonal antibody neutralizes TNFα activity.