Patent ID: 8603437

Claim:
A method for the enzyme-mediated, site-specific, in-vivo localization of water-insoluble molecules within a tumor, which comprises: the administration of a water-soluble prodrug molecule to an animal, wherein said prodrug is represented by the formula: wherein R 1 is selected from the group consisting of a hydrogen radical, a radionuclide, a molecule labeled with one or more radionuclides, a boron atom, a molecule labeled with one or more boron atoms, and a boron cage; R 2 is selected from the group consisting of a hydrogen radical, a radionuclide, and a boron cage; at least one of R 1 and R 2 is not a hydrogen radical; and R 3 is a prosthetic group that can be cleaved by the enzyme; said prodrug being a substrate to said enzyme and hydrolyzed by said enzyme molecules present within the tumor, said hydrolysis forming a water-insoluble drug precipitate molecule, wherein said precipitate is trapped within the tumor.