Patent ID: 7084155

Claim:
A compound of the formula and the salts thereof wherein: A is a 6-membered carbocyclic, saturated ring; R 1 is halo, nitro, cyano, optionally substituted hydroxy, optionally substituted thiol, optionally substituted amino, carboxylate, carboxamide, sulfonate, sulfonamide, C2–4 alkanoyl, alkylsulfonyl, or aroyl; wherein Y is a 6-membered heterocyclic group with one nitrogen, and R 2 and R 3 together with ring E form a substituted benzimidazole ring, which is substituted at any position on the ring with CF 3 , halo, alkyl, alkoxy, carboxyalkyl, hydroxy, benzoyl, phenyl, nitro, cyano, carboxylic acid, alkenyl, cycloalkyl, thiol, amino, acyl, carboxylate, carbamate, carboxamide, sulfonamide, aromatic, or heterocyclic group; or Y is a 6-membered heterocyclic group with two nitrogens, benzoxazolyl, tetrahydroquinolinyl, isoquinolinyl, quinolinyl, 2,3-dioxybenzene, benzimidazolyl, benzothiophenyl, indolyl, 4,5,6,7,-tetrahydrobenzothiophenyl, or benzofuranyl; and R 2 and R 3 together with ring E form an unsubstituted benzimidazole ring; wherein each Y may be substituted with hydroxy, halo, alkoxy, alkyl, substituted alkyl, sulfonyl, or toluenesulfonyl; each R 4 is independently H or C1–6 alkylene; k is 0–1; L 1 is a covalent bond of C1–6 alkyl optionally containing N or O; Ar is phenylene; each n is independently 0–2; R is H or C1–6 alkyl; provided that said compound is other than AMD8926: N-(2-pyridinylmethyl)-N′-(5-nitro-1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine, or AMD8927: N-(2-pyridinylmethyl)-N′-(5,6-dimethyl-1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine.