Patent ID: 7365209

Claim:
A compound of formula: wherein Y is chosen from the group consisting of —O—, —S—, —SO 2 —, —CH 2 — and —N(loweralkyl)-; L is a linker, said linker comprising from one to eight carbons and from zero to three nitrogens, sulfurs and oxygens, wherein at least two atoms are interposed between ring B and carbon β, said linker being straight chain, branched or cyclic, and, when cyclic, attached either at carbons a and b of ring B or, when R 1 is methylene, at R 1 ; Q is NR 9 ; E is hydroxy, or E is a biolabile residue such that E and the carboxyl to which it is attached together form an ester or amide cleavable in vivo to provide a compound in which E is hydroxy; R 1 is chosen from the group consisting of hydrogen, aryl, heteroaryl, (C 1 to C 6 ) hydrocarbon, substituted aryl, (C 1 to C 3 )alkylaryl, —NHCOOR 10 , —NHSO 2 R 10 and —NHCOR 10 ; R 2 is chosen from the group consisting of hydrogen, aryl, heteroaryl, (C 1 to C 6 ) hydrocarbon, substituted aryl, (C 1 to C 3 )alkylaryl, —NHCOOR 10 , —NHSO 2 R 10 and —NHCOR 10 , and R 2a is hydrogen; or taken together R 2 and R 2a form a carbonyl; R 3 and R 4 are independently chosen from the group consisting of hydrogen, (C 1 to C 4 ) hydrocarbon, loweralkoxy, halogen and fluoro(loweralkyl); R 5 , R 6 and R 7 are independently chosen from the group consisting of hydrogen, halogen and fluoro(loweralkyl); R 8 is chosen from hydrogen and lower alkyl; and R 9 is chosen from hydrogen, alkyl, substituted alkyl, aryl and (C 1 to C 3 ) akylaryl; or taken together R 8 and R 9 represent a two to four carbon chain forming a five to seven membered cyclic structure, which may contain one degree of unsaturation; and R 10 is chosen from the group consisting of alkyl, substituted alkyl, aryl and (C 1 to C 3 )alkylaryl.