Patent ID: 8501160

Claim:
Water-insoluble, matrix tablets comprising oxycodone or one of its pharmaceutically acceptable salts, capable of releasing oxycodone into the body over an extended time period and comprising oxycodone within a compression matrix, said matrix comprising a mixture of microcrystalline cellulose and polyvinyl acetate/polyvinylpyrrolidone (80:20) to the proportion of (1:1), magnesium stearate as an anti-adherent agent, a cellulose derivative as a binder, and one or more of the following substances (a) to (f) or a mixture thereof: (a) a substance which irritates the nasal and/or pharyngeal tracts, (b) a viscosity-increasing agent, leading to formation of a gel when the tablet is dissolved in a minimum amount of water, (c) an emetic substance, (d) an aversive coloring agent, (e) a bittering-substance, (f) an antagonist of the active ingredient (s) which may be the subject of drug abuse wherein said matrix represents 50-98% in weight of the total weight of the tablets, and wherein said matrix tablets have a cured outercoating.