Patent ID: 7420001

Claim:
A compound the formula 1: wherein: R 1 and R 2 are, independently, H, CH(OH)R 4 , phenyl, benzofuranyl, or C 1 -C 6 alkyl, with the proviso that when R 1 or R 2 is CH(OH)R 4 , then Z is substituted with NR 4 SO 2 R 5 , SO 2 NR 4 R 5 , benzofuranyl, or C 3 -C 6 cycloalkyl; R 3 is H or C 1 -C 6 alkyl; R 4 and R 5 are, independently with respect to each occurrence, a bond to the other, H, C 1 -C 6 alkyl, or phenyl; G and E are, independently, C(R 6 )═C(R 6 ); R 6 is, independently with respect to each occurrence, H, halogen, NR 4 R 5 , N[(CH 2 ) 2 ] 2 O, N[(CH 2 ) 2 ] 2 NR 4 , NR 4 SO 2 R 5 , NR 4 C(═O)R 5 , NHC(═O)OR 4 , NO 2 , SO 2 NR 4 R 5 , SO 2 R 4 , OR 4 , C(═O)R 4 , COOR 4 , CONR 4 R 5 , CN, phenyl, benzofuranyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; X is N(R 3 )C(═O), OC(═O), OS(O) 2 , NHSO 2 , OCH 2 , CH 2 S(O), or CH 2 S(O) 2 ; and Z is wherein: U is O; W is C(R 6 ); M is C(R 6 ); L is C(R 6 )═C(R 6 ); R 7 is a bond to R 6 , H, halogen, NR 4 R 5 , N[(CH 2 ) 2 ] 2 O, N[(CH 2 ) 2 ] 2 NR 4 , NHSO 2 R 4 , NR 4 C(═O)R 5 , NHC(═O)OR 4 , NO 2 , SO 2 NR 4 R 5 , SO 2 R 4 , OR 4 , C(═O)R 4 , COOR 4 , CONR 4 R 5 , CN, phenyl, benzofuranyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, each optionally substituted with NR 4 R 5 , N[(CH 2 ) 2 ] 2 O, N[(CH 2 ) 2 ] 2 NR 4 , NHSO 2 R 4 , NR 4 C(═O)R 5 , NHC(═O)OR 4 , NO 2 , SO 2 NR 4 R 5 , SO 2 R 4 , OR 8 , C(═O)R 4 , COOR 4 , CONR 4 R 5 , CN, cycloalkyl, phenyl, or benzofuranyl; and R 8 is H, phenyl, benzofuranyl, or C 1 -C 6 alkyl, optionally substituted with NR 4 R 5 , N[(CH 2 ) 2 ] 2 O, N[(CH 2 ) 2 ] 2 NR 4 , NR 4 SO 2 R 5 , NR 4 C(═O)R 5 , NHC(═O)OR 4 , NO 2 , SO 2 NR 4 R 5 , SO 2 R 4 , C(═O)R 4 , COOR 4 , CONR 4 R 5 , CN, cycloalkyl, phenyl or benzofuranyl; or a pharmaceutically acceptable salt thereof.