Patent ID: 7067506

Claim:
A method of inhibiting checkpoint kinase 1 in a cell comprising a step of contacting the cell with a therapeutically effective amount of a compound of formula wherein X 1 is —O—, —S—, —CH 2 —, or —N(R 1 )—; X 2 is —O—, —S—, or —N(R 1 )—; Y is O or S; W is Z is wherein Z is optionally substituted with one to four substituents represented by R 2 , and W is optionally substituted with one to three substituents represented by R 5 ; R 1 is selected from the group consisting of hydro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and aryl; R 2 is selected from the group consisting of halo, optionally substituted C 1-6 alkyl, C 2-6 alkenyl, OCF 3 , NO 2 , CN, NC, N(R 3 ) 2 , OR 3 , CO 2 R 3 1 , C(O)N(R 3 ) 2 , C(O)R 3 , N(R 1 )C(O)R 3 , N(R 1 )C(O)OR 3 , N(R 3 )C(O)OR 3 , N(R 3 )C(O)C 1-3 alkyleneC(O)R 3 , N(R 3 )C(O)C 1-3 alkyleneC(O)OR 3 , N(R 3 )C(O)C 1-3 alkyleneOR 3 , N(R 3 )C(O)C 1-3 alkyleneNHC(O)OR 3 , N(R 3 )C(O)C 1-3 alkyleneSO 2 NR 3 , C 1-3 alkyleneOR 3 , and SR 3 ; R 3 is selected from the group consisting of hydro, C 1-6 alkyl, C 2-6 alkenyl, cycloalkyl, aryl, heteroaryl, SO 2 R 4 , C 1-6 alkyl substituted with one or more of halo, hydroxy, aryl, heteroaryl, heterocycloalkyl, N(R 4 ) 2 , and SO 2 R 4 , C 1-3 alkylenearyl, C 1-3 alkyleneheteroaryl, C 1-3 alkyleneC 3-8 heterocycloalkyl, C 1-3 alkyleneSO 2 aryl, optionally substituted C 1-3 alkyleneN(R 4 ) 2 , OCF 3 , C 1-3 alkyleneN(R 4 ) 3 + , C 3-8 heterocycloalkyl, and CH(C 1-3 alkyleneN(R 4 ) 2 ) 2 , or two R 3 groups are taken together to form an optionally substituted 3- to 6-membered aliphatic ring; R 4 is selected from the group consisting of hydro, C 1-6 alkyl, cycloalkyl, aryl, heteroaryl, C 1-3 alkylenearyl, and SO 2 C 1-6 alkyl, or two R 4 groups are taken together to form an optionally substituted 3- to 6-membered ring; R 5 is selected from the group consisting of C 1-6 alkyl, aryl, N(R 3 ) 2 , OR 3 , halo, N 3 , CN, C 1-3 alkylenearyl, C 1-3 alkyleneN(R 3 ) 2 , C(O)R 3 , and or pharmaceutically acceptable salts, or prodrugs, or solvates thereof.