Patent ID: 8609615

Claim:
A chimeric polypeptide comprising: (i) a functional fragment of an MBNL polypeptide comprising four zinc finger motifs and (ii) a targeting moiety, wherein the targeting moiety comprises an antibody or antigen-binding fragment, which antibody or antigen-binding fragment comprises a heavy chain variable domain (VH) comprising the amino acid sequence set forth in SEQ ID NO: 12 and a light chain variable domain (VL) comprising the amino acid sequence set forth in SEQ ID NO: 14, or which is a humanized antibody or antigen-binding fragment thereof; wherein the MBNL polypeptide is selected from the group consisting of a functional fragment of an MBNL1 polypeptide, an MBNL2 polypeptide, and an MBNL3 polypeptide; and wherein the chimeric polypeptide is capable of binding CUG repeats.