Patent ID: 8569378

Claim:
A method of treating rheumatism or inflammation in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is a heteroaryl group or R 3 R 4 NCO—; Y 1 and Y 2 are each independently —N═ or —CR 11 ═; Y 3 and Y 4 may be the same or different, and are each —CR 12 ═; A is a group represented by general formula (2) below or a group represented by general formula (3) below: R 1 is a hydrogen atom, a halogen atom, a cyano group, a C 1-6 alkyl group, a C 2-7 alkenyl group, a carbamoyl group or a C 2-7 alkynyl group where the C 2-7 alkynyl group may optionally be substituted with a C 1-4 acyl group; R 2 is a C 1-6 alkyl group optionally substituted with a halogen atom; R 3 , R 4 , R 6 , R 7 , R 9 and R 10 are each independently a hydrogen atom, a C 1-6 alkoxy group, a C 3-8 cycloalkyl group or a C 1-6 alkyl group where the C 1-6 alkyl group may optionally be substituted with a group selected from a cyano group, a halogen atom, a hydroxy group, a C 1-6 alkoxy group and —NR 13 R 14 ; the combination of R 3 and R 4 , combination of R 6 and R 7 , and combination of R 9 and R 10 may form, together with the nitrogen atom to which they are bonded, a 4- to 6-membered heterocyclic group having at least one nitrogen atom; R 5 , R 8 , R 13 and R 14 are each independently a hydrogen atom or a C 1-6 alkyl group; R 11 is a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 1-4 acyl group, a C 1-4 acyloxy group or —NR 15 R 16 ; R 12 is a hydrogen atom, a halogen atom or a C 1-6 alkyl group; and R 15 and R 16 are each independently a hydrogen atom or a C 1-4 acyl group.