Patent ID: 8691809

Claim:
A compound having the formula I: or a tautomer, enantiomer or salt thereof, wherein: Y is —(O) x (CH 2 ) y R 11 ; x is selected from 0 and 1; y is selected from 0, 1, 2, and 3; R 11 is selected from aryl, heteroaryl, and saturated or partially saturated heterocycle, wherein when x is 0, said aryl or heteroaryl is substituted with —C(O)NR 1 R 2 or T; R 1 and R 2 are independently selected from hydrogen and alkyl, wherein said alkyl is optionally substituted with —C(O)O(CH 2 ) t R 12 or R 1 and R 2 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring; t is selected from 0, 1, 2, and 3; R 12 is selected from cycloalkyl and aryl; T is selected from heterocycle, —(CHR 7 ) n OR 9 , —(O) u (CH 2 ) n C(O)R 8 , —OSO 2 R 13 , and —CH(OH)CH 2 OH; R 7 is H or —OH; R 8 is selected from —OR 10 and alkyl; R 9 is selected from alkyl and H; R 10 is selected from alkyl, —(CH 2 )R 12 , and hydrogen, wherein said alkyl is optionally substituted with halogen, amine, alkylamine, or dialkylamine; R 13 is selected from —OH, alkyl, CF 3 , cycloalkyl, heterocycle, aryl, and heteroaryl; u is selected from 0 and 1; z is selected from 1, 2, and 3; s is selected from 1 and 2; R 5 is selected from —NR 3 R 4 and —OR 10 ; R 3 and R 4 are independently selected from H, alkyl, and —(O) q (CH 2 ) r P; wherein said alkyl is optionally substituted with one or more —OH; q is selected from 0 and 1; r is selected from 0, 1, 2, and 3; P is selected from aryl, —SO 2 R 6 , and heterocycle; and R 6 is selected from —NH 2 , —NH(alkyl), and —N(alkyl) 2 , provided that when R 11 is aryl or heteroaryl, then a) x+y≧1; or b) R 11 is substituted with T; or c) R 5 is NR 3 R 4 and at least one of R 3 or R 4 is [(O) q (CH 2 ) r P] and q+r≧1; or d) at least one of R 1 or R 2 is alkyl substituted with —C(O)O(CH 2 )R 12 .