Patent ID: 6855824

Claim:
A production method of a quinoline derivative of the formula (V) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 each independently represent a hydrogen atom, a halogen atom, a trifluoromethyl group, a trifluoromethoxy group, an optionally protected hydroxyl group, an alkyl group optionally having substituents, a cycloalkyl group optionally having substituents, an aryl group optionally having substituents, an aralkyl group optionally having substituents, an alkoxyl group optionally having substituents or an aryloxy group optionally having substituents, which comprises: reacting a quinolinecarbaldehyde of the formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined above, with any of the following compounds (a) to (c) in the presence of a base, (a) a phosphonium salt compound of the formula (II) wherein R 7 and R 8 each independently represent a hydrogen atom, an alkyl group optionally having substituents, an acyl group optionally having substituents or an aralkyl group optionally having substituents, or in combination represent an alkylene group, an arylene group or an aralkylene group, R 9 represents an alkyl group optionally having substituents or an aryl group optionally having substituents, and X represents a halogen atom, (b) a phosphonate compound of the formula (III) wherein R 7 , R 8 and R 9 are as defined above, and (c) a phosphonate compound of the formula (IV) wherein each R 9 is as defined above, and R 10 and R 11 each independently represent a hydrogen atom, an alkyl group optionally having substituents, a cycloalkyl group optionally having substituents, an aryl group optionally having substituents or an aralkyl group optionally having substituents, or in combination represent an alkylene group, an arylene group or an aralkylene group, and then hydrolyzing the resulting compound.