Patent ID: 8524871

Claim:
An isolated or purified antibody which specifically recognizes a peptide-type compound or a pharmaceutically acceptable salt thereof having the amino acid sequence selected from the group consisting of SEQ ID NOs: 1, 2, 3, 8, 9, 10, 11, 16, 17, 22, 25, 26, 27, 28, 29, 30 and 31, wherein one or two amino acid residues outside of positions 1 to 4 from the amino-terminal of the selected SEQ ID NO: may be deleted, and/or wherein one or two amino acid residues outside of positions 1 to 4 from the amino-terminal of the selected SEQ ID NO: may be substituted, wherein the amino acid residue at position 2 or 3 from the amino-terminal of the selected SEQ ID NO: is a modified amino acid in which: (1) one saturated or unsaturated alkyl chain containing 1 to 35 carbon atoms is introduced at the α carbon atom of the amino acid by an ester, ether, thioether, thioester, amide, carbamide, thiocarbamide or disulfide linkage; (2) one saturated or unsaturated alkyl chain containing 1 to 35 carbon atoms is introduced at the α carbon atom of the amino acid by an alkylene group containing 1 to 10 carbon atoms and by an ester, ether, thioether, thioester, amide, carbamide, thiocarbamide or disulfide linkage; or (3) one saturated or unsaturated alkyl chain containing 1 to 35 carbon atoms is introduced at the α carbon atom of the amino acid, wherein said peptide-type compound or pharmaceutically acceptable salt thereof has an activity of increasing intracellular calcium ion concentration, and wherein the isolated or purified antibody specifically recognizes the alkyl chain of the modified amino acid of the selected SEQ ID NO:.