Patent ID: 7041657

Claim:
A method for achieving at least a transient, localized, physiological response, comprising: topically administering to a patient in need of said modulation, a sufficient amount of a non-barrier forming material comprising poly-β-1→4 N-acetylglucosamine polymers, wherein the poly-β-1→4 N-acetylglucosamine polymer comprises about 50 to about 150,000 N-acetylglucosamine monosaccharides covalently attached in a β-1→4 conformation, wherein the non-barrier forming material is in the form of a solution, a suspension, an emulsion, a spray, or a foam, so that the patient experiences at least a transient, localized physiological response selected from the group consisting of stimulation of endothelin-1 release, vasoconstriction, and reduction in blood flow out of a breached vessel.