Patent ID: 6939540

Claim:
A method for enhancing bone density or formation, the method comprising (a) administering to at least one first cell within a bone or within a tissue immediately surrounding a bone an adenoviral vector comprising at least one first nucleic acid encoding a VEGF 121, and (b) administering to at least one second cell within the bone or within a tissue immediately surrounding the bone an adenoviral vector comprising at least one second nucleic acid encoding at least one osteogenic protein, wherein the osteogenic protein is selected from the group consisting of a latent TGF binding protein (LTBP), latent membrane protein-1(LMP-1), a heparin-binding neurotrophic factor (HBNF), a parathyroid hormone (PTH), a growth factor receptor, a LIM mineralization protein (LMP), a hedgehog protein, and midkine (MK), such that the first nucleic acid is expressed in the first cell to produce the vascular endothelial growth factor, and the second nucleic acid is expressed in the second cell to produce the osteogenic protein, whereby bone density or formation is enhanced within the region.