Patent ID: 7981923

Claim:
A compound of formula II: or a pharmaceutical salt thereof, wherein: m is from 0 to 3; n is from 1 to 3; Ar is optionally substituted aryl or optionally substituted heteroaryl; each R 1 is independently halo, alkyl, haloalkyl, alkoxy, hydroxy, heteroalkyl, cyano, —S(O) t —R a , —C(═O)—NR b R c , —SO 2 —NR b R c , —N(R d )—C(═O)—R e , or —C(═O)—R e , where t is from 0 to 2, R a , R b , R c , R d and R e each independently is hydrogen or alkyl, and R f is hydrogen, alkyl, alkoxy or hydroxy; R 2 is hydrogen or alkyl; and R 4 is alkyl, hydroxyalkyl, alkoxy, alkoxyalkyl or —(CH 2 ) p —NR 5 R 6 , wherein p is 0 or 1; R 5 is hydrogen or alkyl; and R 6 is hydrogen, alkyl, guanidinyl, hydroxyalkyl or alkoxyalkyl, provided that: when m is O and R 4 is —NHCH 3 , —N(CH 3 ) 2 , —CH 2 NH 2 , —CH 2 NHCH 3 , —CH 2 N(CH 3 ) 2 , or —CH 2 OH, then Ar is not 3-fluoro-phenyl; when m is O and R 4 is —NH 2 or guanidinyl, then Ar is not phenyl or 3-fluoro-phenyl; when m is 1, R 1 is fluoro at the 8-position of the tetralin ring system, and R 4 is methyl, then Ar is not phenyl, when m is 0 and R 4 is methyl, then Ar is not 3-fluoro-phenyl or indol-3-yl; and when m is 0 and R 4 is methoxy or ethoxy, then Ar is not 3-fluoro-phenyl or 2-fluoro-phenyl.