Patent ID: 7872032

Claim:
A compound of formula I: wherein ARYL is phenyl or pyridinyl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 1-6 perfluoroalkyl, C 1-6 alkylthio, hydroxy, hydroxyC 1-6 alkyl, C 1-4 acyloxy, nitro, cyano, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino and C 1-6 alkoxycarbonyl; Z is —SO 2 (CH 2 ) n , —(CH 2 )—CO—, —O(CH 2 ) n —CO—, or —(CH 2 ) n —Y—(CH 2 ) n —CO—, wherein Y is NR 3 , O or S, R 3 is selected from the group consisting of H, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkylC 3-8 cycloalkyl and benzyl, and n is independently an integer from 1 to 5; X is NR 3 , O or S, wherein R 3 is as defined above; R 1 is H, halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 perfluoroalkyl; hydroxyC 1-6 alkyl, nitro, cyano, or C 1-6 alkylamino; and R 2 is substituted or unsubstituted phenyl, pyridinyl or thienyl wherein the substituents are selected from the group consisting of halogen, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 1-6 perfluoroalkyl, C 1-6 alkylthio, hydroxy, hydroxyC 1-6 alkyl, C 1-4 acyloxy, nitro, cyano, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino and C 1-6 alkoxycarbonyl; provided that when Z is —O(CH 2 ) n — or —SO 2 (CH 2 ) n —, and ARYL is phenyl, then R 2 is other than phenyl; or a stereoisomer, or a tautomer thereof, or a pharmaceutically acceptable salt thereof.