Patent ID: 7998951

Claim:
A compound of formula I wherein: A is a 6-membered ring with 1 O atom and contains 0 double bonds, and is substituted with 0-1 substituents selected from COR 3 and CONR 9 R 10 ; R 1 is CO 2 R 3 or CONR 4 R 5 ; R 2 is C 5-7 cycloalkyl; R 3 is hydrogen or alkyl; R 4 is hydrogen, alkyl, cycloalkyl, SO 2 R 6 , or R 5 is hydrogen, alkyl, or cycloalkyl; R 6 is alkyl, haloalkyl, cycloalkyl, amino, alkylamino, or dialkylamino; or R 6 is pyrrolidinyl, piperidinyl, piperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl, and is substituted with 0-2 substituents selected from halo and C 1-6 alkyl; R 7 and R 8 are independently hydrogen or alkyl; or R 7 and R 8 taken together are ethylene, propylene, butylene, pentylene, or hexylene; R 9 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, (alkoxy)alkyl, aminoalkyl, (alkylamino)alkyl, or (dialkylamino)alkyl; R 10 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, (alkoxy)alkyl, aminoalkyl, (alkylamino)alkyl, or (dialkylamino)alkyl; or NR 9 R 10 taken together is pyrrolidinyl, piperidinyl, piperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl, and is substituted with 0-2 substituents selected from halo, hydroxy, alkyl, amino, alkylamino, dialkylamino, pyridinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, and thiomorpholinyl; and Ar 1 is phenyl substituted with 0-2 substituents selected from halo, alkyl, and alkoxy; or a pharmaceutically acceptable salt thereof.