Patent ID: 6888004

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof wherein R 1 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 thioalkyl, cyano, halo, C 3-7 cycloalkyl, â€”C 1-6 alkylene-C 3-7 cycloalkyl, C 2-6 alkenyl or C 3-6 alkynyl; R 2 is C(D)NR 3 R 4 , Dâ€²â€”Dâ€³(R 3 )(R 4 ) or CH 2 N R 3 R 4 Dâ€² is CH 2 or a bond: Dâ€³ is C, Câ€”OH or CH wherein said C is attached to R 3 by a single or double bond; said C is attached to R 4 by a single or double bond; provided that C is not attached to both R 3 and R 4 by double bonds; said CH is attached to R 3 and R 4 by single bonds; said C of Câ€”OH is attached to R 3 and R 4 by single bonds; D is O or S; R 3 and R 4 are each independently selected from the group consisting of H, C 1-6 alkyl, C 1-6 haloalkyl, â€”C 1-6 hydroxyalkyl, â€”C 1-4 alkylene-Oâ€”C 1-4 alkyl, â€”C 1-3 alkylene-C 1-6 thioalkyl, â€”C 2-6 alkylidene-(C 1-4 alkoxy) 2 , C 3-7 cycloalkyl, â€”C 1-6 alkylene-C 3-7 cycloalkyl, C 2-6 alkenyl, C 3-6 alkynyl, â€”C 1-6 alkylene-CN, â€”C 1-6 alkylene-heterocycle and â€”C 1-6 alkylene-aryl; wherein said aryl of said â€”C 1-6 alkylene-aryl is optionally substituted with one to three of the same or different substituents selected from the group consisting of fluoro, chloro, bromo, cyano, nitro, C 1-4 alkyl and C 1-3 alkoxy; or R 3 and R 4 together with the nitrogen to which they ace attached form a five or six-membered heterocycle, said heterocycle optionally containing one additional heteroatom selected from the group consisting of N, S and O; and said heterocycle optionally substituted with one or more groups selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, aryl, â€”C 1-4 alkylene-aryl, pyridyl and halogen; wherein said aryl of said â€”C 1-4 alkylene-aryl is optionally substituted with one to three of the same or different substituents selected from the group consisting of fluoro, chloro, bromo, cyano, nitro and C 1-3 alkoxy; X is C; Y is C; A is wherein X 1 is N and is attached to X; Y 1 is N and is attached to Y; G is wherein Y 2 is CH, CH 2 , (C(O), C(S), CR 5 , or CHR 5 and is attached to Y 1 ; J is a bond; Z 1 is CH, CH 2 , C(O), C(S), CR 7 , or CHR 7 and is attached to Z; wherein R 5 , and R 7 are each independently selected from the group consisting of â€”CN, â€”C 1-4 alk(en)ylene-CN, halo, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 alkynyl, C 1-6 haloalkyl, aryl, â€”C 1-4 alk(en)ylene-aryl, â€”C 1-4 alk(en)ylene-heterocyclo, heterocyclo, â€”C 1-4 alk(en)ylene-amino, â€”C 1-4 alkylene-amino-C 1-4 alkyl, aryl-amino, -amino-(C 1-6 alk(en)yl) 1-2 , -amino-aryl, -amino-heterocyclo, 1-6 alkoxy, â€”Oâ€” aryl and -O-heterocyclo; and Z is Nâ€”V, wherein V is phenyl, 2-pyridyl or 3-pyridyl substituted with two to three of the same or different substituents selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-6 thioalkyl, C 1-4 haloalkyl, halogen, N(C 1 -C 4 alkyl) 2 and CN.