Patent ID: 8071628

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein: X is â€”C(O)â€”NHâ€”; Y is â€”(CH 2 ) n â€”, wherein n is 0 or 1; R 1 , R 2 , R 3 and R 4 independently from each other are selected from the group consisting of: (1) hydrogen, (2) halogen, (3) lower-alkyl, (4) fluoro-lower-alkyl, (5) carbamoyl, (6) lower-alkyl-NHâ€”C(O)â€”NHâ€”, (7) aryl-lower-alkyl-NHâ€”C(O)â€”Hâ€”, and (8) lower-alkyl-SO 2 â€”NH-lower-alkyl; R 5 is phenyl or a heteroaryl selected from the group consisting of (a) thiophenyl, (b) pyridinyl, and (c) thiazolyl, in which said phenyl or heteroaryl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of: (1) halogen, (2) lower-alkyl, (3) fluoro-lower-alkyl, (4) carboxy, (5) carboxy-lower-alkyl, (6) carboxy-lower-alkoxy, (7) 1H-tetrazol-5-yl, and (8) 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; R 6 is: wherein: R 13 , R 14 and R 15 independently from each other are selected from the group consisting of hydrogen, lower-alkyl, halogen, fluoro-lower-alkyl, fluoro-lower-alkoxy, NO 2 and â€”NH 2 â€”C(O)â€”; and R 16 is hydrogen or lower-alkoxy.