Patent ID: 8580817

Claim:
A compound having Formula I, its enantiomers, diastereoisomers, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof, wherein: A is C 6-10 aryl, Heterocyle, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; R 17 is C 1-6 alkyl or B is C 6-10 aryl, Heterocyle, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; R 1 is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 2 is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 3 is H, C 1-6 alkyl or C 3-8 cycloalkyl; R 4 is H, C 1-6 alkyl or C 3-8 cycloalkyl; R 5a is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 5b is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 5c is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 5d is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 6 is H, —S(O) 2 R 11 , —C 1-6 alkyl, C(O)R 12 , —(CH 2 ) n NR 13 R 14 , —(CH 2 ) m heterocycle, NR 13 R 14 , C 3-8 cycloalkyl, C 6-10 aryl, or heterocycle; R 7 is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 8 is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 9 is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; R 10 is H, halogen, —S(O)R 15 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl or hydroxyl; X is O or S; Y is O or S; R 11 is H, hydroxyl, —C 1-6 alkyl, C 3-8 cycloalkyl or NR 13 R 14 ; R 12 is H, hydroxyl, —C 1-6 alkyl, hydroxyl, C 3-8 cycloalkyl, NR 13 R 14 or —OC 1-6 alkyl; R 13 is H, —C 1-6 alkyl, C 3-8 cycloalkyl, SO 2 R 11 or C(O)R 16 ; R 14 is H, —C 1-6 alkyl or C 3-8 cycloalkyl; R 15 is —C 1-6 alkyl, or C 3-8 cycloalkyl; R 16 is H, —C 1-6 alkyl or C 3-8 cycloalkyl; n is 1-4; and m is 1-4.