Patent ID: 8889643

Claim:
The pharmaceutical composition comprising a compound capable of functionally and selectively blocking the shorter isoform of Bruton's tyrosine kinase (BTK) having the amino acid sequence of SEQ ID NO: 2 and a chemotherapeutic drug for the treatment of epithelial tumours, wherein the compound capable of functionally and selectively blocking BTK comprises (a) a small interfering RNA (siRNA) or a short hairpin RNA (shRNA) targeting a 5′-untranslated region (5′-UTR) (SEQ ID NO: 1) of a messenger RNA (mRNA) encoding a shorter isoform of Bruton's Tyrosine Kinase (BTK) having the amino acid sequence of SEQ ID NO: 2, wherein the shorter isoform does not contain amino acid residues 1-88 or 2-89 of the Bruton's Tyrosine Kinase (BTK) set forth in SEQ ID NO: 3; and (b) a pharmaceutically acceptable carrier.