Patent ID: 7250262

Claim:
A method for identifying a candidate compound that modulates hematopoiesis, comprising: i) combining a compound to be tested with hematopoletic cells expressing a polypeptide selected from the group consisting of: a) a polypeptide comprising the amino acid sequence of SEQ ID NO:26, wherein the polypeptide has chloride channel protein activity; and b) a polypeptide encoded by the nucleotide sequence set forth in SEQ ID NO:25, wherein the polypeptide has chloride channel protein activity; under conditions suitable for binding of the test compound to the polypeptide; ii) detecting binding of the test compound to the polypeptide to thereby identify a compound which binds to the polypeptide; and iii) determining if the hematopoietic cells differentiate into mature cells; thereby identifying a compound that modulates hematopolesis.