Patent ID: 8501805

Claim:
A bicyclic nucleoside having Formula I: wherein: Bx is a heterocyclic base moiety; one of T 1 and T 2 is H or a hydroxyl protecting group and the other of T 1 and T 2 is H, a hydroxyl protecting group or a reactive phosphorus group; q 1 , q 2 , q 3 , q 4 , q 5 and q 6 are each, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl or substituted C 2 -C 6 alkynyl; wherein each substituted group is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, oxo, OJ 1 , NJ 1 J 2 , SJ 1 , N 3 , OC(═O)J 1 and CN, wherein each J 1 and J 2 is, independently, H or C 1 -C 6 alkyl; and wherein at least one of q 1 , q 2 , q 3 , q 4 , q 5 and q 6 is other than H.