Patent ID: 7256187

Claim:
A compound of structural Formula I or Formula II: or pharmaceutically acceptable salts thereof; wherein: L 3 is any combination of 0 to 5 groups which independently are the same or different and are selected from —CR 1 R 2 —, —NR 3 —, —O—, —C(═O)—, —S(═O) 0-2 —, —C═N—, alkylene, alkenylene, and alkynylene; X 3 is —H, —OH, —NH 2 , —CO 2 H, halo, haloalkyl, —CN, alkyl, aryl, or -Q 3 ; L 11 is any combination of 0 to 5 groups which independently are the same or different and are selected from —CR 1 R 2 —, —NR 3 —, —O—, —C(═O)—, —S(═O) 0-2 —, —C═N—, alkylene, alkenylene, and alkynylene; X 11 is —H, —OH, —NH 2 , —CO 2 H, halo, haloalkyl, —CN, alkyl, aryl, or -Q 11 ; Y is, when the compound is Formula I, ═O or ═NR 4 , and, when the compound is Formula II, —OH, —NHR 4 , —OR 5 , —OCH 2 CO 2 H, or —OCH 2 CONR 6 R 7 ; Z is —H or —COCH 2 R 8 , wherein R 8 is —H, —OH, halo, —CN, —CO 2 H, —CONR 9 R 10 , —NR 11 R 12 , —OR 13 , —S(═O) 0-2 R 14 , or—Q 25 ; wherein R 1 is —H, —OH, —SH, alkyl, cycloalkyl, aryl, alkoxy, alkylthio, alkylamino, or dialkylamino, wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 11 , R 12 , R 13 , and R 14 independently are the same or different and are H, alkyl, or aryl, and where Q 3 , Q 11 , and Q 25 independently are the same or different and are any of the structures: