Patent ID: 7276233

Claim:
A method for suppressing tumor growth in a mammal comprising: administering to said mammal the combination of a replication competent, target cell-specific adenovirus, said adenovirus is selected from the following: an adenovirus comprising an E1A gene operably linked to a probasin (PB) TRE and an E1B gene operably linked to a prostate specific antigen (PSA) TRE; an adenovirus comprising a PSA TRE operably linked to an E1A gene; and an adenovirus comprising an alpha-fetoprotein (AFP) TRE operably linked to an E1A gene and an IRES between the adenoviral E1A gene and an adenoviral E1B gene, wherein said target cell-specific adenovirus results in virus replication-dependent cytolysis; and; at least one antineoplastic agent selected from pacitaxel and docetaxel, in a combined dosage effective to effect a greater reduction in the tumor cell population when compared to administration of the adenovirus vector or antineoplastic agent alone.