Patent ID: 8465769

Claim:
A pharmaceutical preparation comprising a core that is enveloped by a coating; wherein said core comprises an active ingredient, which has a solubility in water of at least 10 g/l at 20° C., and an organic acid, a salt of an organic acid, or both; and wherein said coating comprises silicon dioxide particles having an average particle size ranging from 1 to 50 μm, and one or more (meth)acrylate copolymer(s), where at least 60% by weight of said copolymer(s) are free-radically copolymerized units containing 93 to 98% by weight C 1 - to C 4 -alkyl esters of acrylic or of methacrylic acid monomers and 2% to 7% by weight (meth)acrylate monomers having a quaternary ammonium group in the alkyl radical; wherein said preparation contains said coating in an amount ranging from 10 to 200 wt. % based on the weight of the core; and wherein said pharmaceutical preparation exhibits sigmoidal active ingredient release characteristics with a lag phase, a pulse phase and a run-out phase, characterized by an active ingredient release in the paddle apparatus at 100 rpm in buffer of pH 6.8 according to the European pharmacopoeia of approximately 10% during the lag phase and a subsequent active ingredient release of approximately a further 80% within less than 4 hours in the pulse phase.