Patent ID: 7972622

Claim:
A method of manufacturing a rapid dissolving tablet suitable for buccal delivery of an active agent containing one or more active medicaments, comprising the steps of (1) supplying a biologically acceptable carrier liquid through a first supply tube to an outlet of said first supply tube, said biologically acceptable carrier liquid comprising a solution of a biologically acceptable polymer; (a) wherein said biologically acceptable polymer is selected from the group consisting of gelatin, polyvinyl pyrrolidone, vinylpyrrolidone/vinylacetate copolymer, vinylpyrrolidone/vinylimidazole copolymer, and polyvinyl alcohol in a mixture of water and ethanol; and (b) wherein said water and ethanol are present in said carrier liquid at a ratio of from about 1:0.8 to about 1:1.5; (2) establishing an electric field between the outlet of said first supply tube and a support surface that is spaced from the outlet to cause liquid issuing from the outlet to form at least one fiber or fibrils of said carrier liquid; (3) causing said fibers or fibrils to deposit onto the support surface to form a fibrous porous web or mat; (4) supplying a biologically acceptable carrier liquid comprising an active medicament through a second supply tube to an outlet of said second supply tube; (5) applying a charge to said carrier liquid of Step 4 opposite the charge of said first electric field of Step 2 to form a layer of fibers or fibrils comprising said active ingredient on top of said fibrous porous web or mat from Step 3; (6) repeating Steps 1-3 so as to deposit a layer of fibers or fibrils on the surface of the layer of fibers or fibrils of active ingredient from Step 5; and (7) forming a plurality of individual tablets from the layers produced from step 6; and wherein the individual tablets are capable of rapid dissolution suitable for buccal delivery.