Patent ID: 8288566

Claim:
A process for palladium-catalyzed enantioselective allylic amination of Î±,Î²-unsaturated carboxylic acid derivatives, said process comprising reacting a racemic mixture of a carboxylic acid derivative having the structural formula I: with a chiral ligand and a palladium catalyst in the presence of a nucleophile, to yield enantiometrically enriched Î±,Î²-unsaturated carboxylic acid derivatives having the formulas II and III: wherein in formulas I, II and III, R1 is a benzyl group, an n-butyl group, or a cyclohexyl group; R2 is a benzyl group or hydrogen; XR3 is an ethoxy group, an amide, or a tert-butoxy group; or formulas I and III are as recited above and in formula II, NR1R2 is a phtalimidyl-substituent.