Patent ID: 7635754

Claim:
A chimeric polypeptide, comprising an interleukin-4 (IL-4) mutein receptor antagonist operatively linked to an interleukin-9 (IL-9) mutein receptor antagonist, wherein the IL-4 mutein receptor antagonist comprises the amino acid sequence of wild-type human IL-4 with one or more of the amino acids at positions 121, 124 or 125 substituted with another natural amino acid, and the IL-9 mutein receptor antagonist comprises the amino acid sequence of wild-type human IL-9 with one or more of the amino acids at positions 126 or 133 substituted with another natural amino acid, wherein the IL-9 mutein receptor antagonist is positioned N-terminal to the IL-4 mutein receptor antagonist, and wherein the chimeric polypeptide reduces or inhibits the association of an interleukin with an IL-4 receptor, an IL-9 receptor, an interleukin-13 (IL-13) receptor, or a combination thereof.