Patent ID: 6878743

Claim:
A compound having the structure (I): and pharmaceutically acceptable derivatives thereof, wherein R 1 is H, an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl, or heteroalkylheteroaryl moiety; n is 0 or 1; A is CR A , C(R A ) 2 , C═O, S, NR A , N(R A ) 2 , or O; B is CR B , C(R B ) 2 , C═O, S, NR B , N(R B ) 2 , or O; D is CR D , C(R D ) 2 , C═O, S, NR D , N(R D ) 2 , or O; E is CR E , C(R E ) 2 , C═O, S, NR E , N(R E ) 2 , or O; G is CR G , C(R G ) 2 , C═O, S, NR G , N(R G ) 2 , or O; J is CR J ; each of A—B, B—D, D—E, E—G, G—J and A—J are connected by a single or double bond as valency and stability permits; each occurrence of R A , R B , R D , R E , R G and R J is independently hydrogen, halogen, —OR 2 , —N(R 2 ) 2 , —SR 2 , —CN, —COOR 2 , —COR 2 , —CON(R 2 ) 2 , —SOR 2 , —SO 2 R 2 , —SO 2 N(R 2 ) 2 , —NR 2 SO 2 R 2 , —O(C═O)N(R 2 ) 2 , —NR 2 (C═O)N(R 2 ) 2 , —NR 2 (C═S)N(R 2 ) 2 , —NR 2 SO 2 N(R 2 ) 2 , or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl, or heteroalkylheteroaryl moiety optionally independently substituted with one or more occurrences of R 2 , wherein each occurrence of R 2 is independently hydrogen, halogen, —OR 3 , —N(R 3 ) 2 , —SR 3 , —CN, —COOR 3 , —COR 3 , —CON(R 3 ) 2 , —SOR 3 , —SO 2 R 3 , —SO 2 N(R 3 ) 2 , —NR 3 SO 2 R 3 , —O(C═O)N(R 3 ) 2 , —NR 3 (C═O)N(R 3 ) 2 , —NR 3 (C═S)N(R 3 ) 2 , —NR 3 SO 2 N(R 3 ) 2 , or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl, or heteroalkylheteroaryl moiety; wherein each occurrence of R 3 is independently hydrogen, or an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl, or heteroalkylheteroaryl moiety, and wherein at least one of R B or R D comprises —SR 2 , —SOR 2 , —SO 2 R 2 , —SO 2 N(R 2 ) 2 , —NR 2 SO 2 R 2 , —N(R 2 ) 2 , —(C═O)N(R 2 ) 2 , —NR 2 (C═O)R 2 , —O(C═O)N(R 2 ) 2 , —NR 2 (C═O)N(R 2 ) 2 , —NR 2 (C═S)N(R 2 ) 2 , —NR 2 SO 2 N(R 2 ) 2 , or is an alkyl or heteroalkyl group substituted with one or more occurrences of R 2 , wherein R 2 is —SR 3 , —SOR 3 , —SO 2 R 3 , —SO 2 N(R 3 ) 2 , —NR 3 SO 2 R 3 , —N(R 3 ) 2 , —(C═O)N(R 3 ) 2 , —NR 3 (C═O)R 3 , —O(C═O)N(R 3 ) 2 , —NR 3 (C═O)N(R 3 ) 2 , —NR 3 (C═S)N(R 3 ) 2 , —NR 3 SO 2 N(R 3 ) 2 , wherein R 3 is an aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl, or heteroalkylheteroaryl moiety, whereby each of the foregoing aliphatic, heteroaliphatic, alkyl and heteroalkyl moieties may be independently substituted or unsubstituted, cyclic or acyclic, linear or branched, and each of the foregoing aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl and heteroalkylheteroaryl moieties may be independently substituted or unsubstituted.