Patent ID: 8568784

Claim:
A pharmaceutical composition, comprising: planetary ball milled nanoparticles comprising: a biologically active agent; polyethylene glycol; and at least one biopolymer selected from the group consisting of starch, cellulose, collagen, lactose and alginate, wherein the nanoparticles are coated with a coating agent comprising at least one of polycaprolactone and polyethylene glycol and wherein the planetary ball milled nanoparticles are prepared by a method comprising the steps of: (a) mixing the at least one biopolymer dissolved in an aqueous solution with the biologically active agent to form a first mixture; (b) mixing the first mixture with polyethylene glycol to form a second mixture; (c) drying the second mixture; (d) producing nanoparticles of the dried second mixture by planetary ball milling; and (e) coating the planetary ball milled nanoparticles with the coating agent.