Patent ID: 8450304

Claim:
A compound of Formula (I) wherein: R 1 is pyridyl, pyridyl-N-oxide, 1H-pyridin-2-onyl, indolyl, pyrazinyl, 3-H-thiazol-2-onyl, pyrimidyl, benzooxazolyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, thiophenyl, furyl, [1,2,4]oxadiazolyl or [1,3,4]thiadiazolyl; wherein said pyridyl, pyridyl-N-oxide, pyrimidyl, pyrazolyl, imidazolyl, thiophenyl, or thiazolyl is optionally substituted with one substituent selected from the group consisting of OC (1-4) alkyl, OC (3-6) cycloalkyl, OCH 2 CF 3 , OCH 2 Ph, F, CN, CH 2 CN, C (1-4) alkyl, CH 2 CF 3 , N(C (1-4) alkyl) 2 , C (1-4) alkylOH, Si(CH 3 ) 3 , —C≡CH, SCH 3 , S(O)CH 3 , SO 2 CH 3 , pyrrolidinyl, OH, NH 2 , NHCN, CO 2 H, CONH 2 , NHCO 2 C (1-4) alkyl, N(SO 2 CH 3 ) 2 , NHSO 2 CH 3 , NHC(O)CF 3 , NHC (1-4) alkyl, NHCO 2 H, NHCO 2 C (1-4) alkyl, NHCOC (1-4) alkyl, NHCONH 2 , NHCONHC (1-4) alkyl, and Br; or said pyridyl may be substituted with one OCH 3 group and one CH 3 ; or wherein said pyrimidyl is optionally substituted with one N(C (1-4) alkyl) 2 group or one or two OCH 3 groups; or wherein said thiazolyl is optionally substituted on two adjacent carbon atoms to form fused bicyclic system benzothiazol-2-yl, or wherein said benzothiazol-2-yl is optionally substituted with Br or OCH 3 ; or wherein said 1H-pyridin-2-onyl is optionally substituted with one substituent selected from the group consisting of CH 2 CN, C (1-4) alkyl, CH 2 CF 3 , and CH 2 CH 2 OH, or said 1H-pyridin-2-onyl may be optionally substituted with up to 2 methyl groups; or wherein said [1,2,4]oxadiazolyl is optionally substituted on any carbon atom with CCl 3 , or pyrrolidinyl, or alternatively both hydrogens on said carbon atom of said [1,2,4]oxadiazolyl may be replaced by an oxo group; R 2 is C (1-4) alkyl, NH 2 , NO 2 , NHCH 2 CH 2 OH, N(C (1-4) alkyl) 2 , N(SO 2 CH 3 ) 2 , CN, F, Cl, Br, CF 3 , C (3-6) cycloalkyl, heterocyclyl, OCF 3 , OCF 2 H, CF 2 H, or OC (1-4) alkyl; R 3 is H, F, Cl, CF 3 , or OC (1-4) alkyl; alternatively, R 2 and R 3 may be taken together with their attached phenyl to form a benzo[1,3]dioxolyl, 2,3-dihydro-benzofuranyl, or 2,3-dihydro-benzo[1,4]dioxinyl group; R 4 is H, OC (1-4) alkyl, or F; and hydrates, tautomers, and pharmaceutically acceptable salts thereof.