Patent ID: 8273749

Claim:
A compound of structural formula I: or pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof: wherein: R 1 =aryl or heteroaryl, optionally substituted with 1-3 substituents consisting of: C 1-6 alkyl, C 1-4 -fluoroalkyl, C 6-10 -aryl, or C 6-10 heteroaryl, F, Cl, Br, CN, OR 5 , NR 5 R 6 , SO 2 R 5 , SO 2 NR 5 R 6 , NR 5 SO 2 R 6 , CO 2 R 5 , CONR 5 R 6 ; R 2 =C 1-6 alkyl, C 1-6 fluoroalkyl; R 3 =(CH 2 ) n aryl or (CH 2 ) n heteroaryl, wherein each aryl or heteroaryl is optionally substituted with 1-3 substituents consisting of: C 1-6 alkyl, C 1-4 -fluoroalkyl, C 6-10 -aryl, C 6-10 heteroaryl, F, Cl, Br, CN, OR 5 , NR 5 R 6 , SO 2 R 5 , SO 2 NR 5 R 6 , NR 5 SO 2 R 6 , CO 2 R 5 , CONR 5 R 6 ; each R 4 is independently selected from H, C 1-6 alkyl, C 1-4 -fluoroalkyl, aryl, heteroaryl, F, Cl, Br, CN, OR 5 , NR 5 R 6 , SO 2 R 5 , SO 2 NR 5 R 6 , NR 5 SO 2 R 6 , CO 2 R 5 , and CONR 5 R 6 ; R 5 and R 6 are each independently selected from H, C 1-6 alkyl, C 1-4 -fluoroalkyl, C 3-7 -cycloalkyl, C 6-10 -aryl, and C 6-10 heteroaryl or R 5 and R 6 join to form a 3-7 member carbocyclic or heterocyclic ring and n=0-6.