Patent ID: 8163781

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or ester thereof; wherein: X is a direct bond, oxygen, or —S(O) 2 —; and wherein X is bonded to the ring containing Q and B by substitution of a hydrogen atom of a ring carbon atom; A, B, Q, and W, independently of each other, are carbon or nitrogen with the proviso that: (1) B and Q are not both nitrogen, (2) W and A are not both nitrogen, and (3) when A, B, Q or W is nitrogen the nitrogen is unsubstituted; R 1 is hydrogen or methyl; R 2 is selected from the group consisting of: (1) hydrogen; (2) halogen; (3) lower alkyl optionally substituted by halogen; and (4) lower cycloalkyl optionally substituted by lower alkyl; R 3 , R 4 and R 5 are bonded to the ring containing A and W by substitution of a hydrogen atom of a ring carbon atom; and R 3 , R 4 and R 5 , independently of each other, are selected from the group consisting of: (1) hydrogen; (2) hydroxyl; (3) halogen; (4) nitro; (5) cyano; (6) lower alkyl optionally substituted by halogen or hydroxyl; (7) lower alkoxy optionally substituted by halogen; (8) lower alkanoyl; (9) carbamoyl, lower alkylaminocarbonyl, or lower dialkylaminocarbonyl; (10) lower alkylcarbonylamino; (11) lower alkylsulfinyl or lower cycloalkylsulfinyl; (12) lower alkylsulfonyl or lower cycloalkylsulfonyl; and (13) trimethylsilyl; or alternatively, one of R 3 , R 4 or R 5 is hydrogen and the remaining two of R 3 , R 4 or R 5 are bound together with the carbon atom to which they are attached to form a ring of 5 or 6 carbon atoms.