Patent ID: 8575339

Claim:
A compound isolated from a non-selective reaction product mixture of erlotinib selected from the group cosisting of: N-(3-ethynyl-5-fluorophenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(5-ethynyl-2-fluorophenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(5-ethynyl-2-chlorophenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynyl-4-chlorophenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-5,8-difluoro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-5,8-difluoro-6,7-bis(2-methoxyethoxy)-5,8-dihydroquinazolin-4-amine; N-(3-ethynylphenyl)-5-fluoro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-5-chloro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-8-fluoro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-5,6,7,8-tetrafluoro-6,7-bis(2-methoxyethoxy)-5,6,7,8-tetrahydroquinazolin-4-amine; N-(3-ethynyl-4-fluorophenyl)-5-fluoro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynyl-4-chlorophenyl)-5-fluoro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(5-ethynyl-2-fluorophenyl)-5-fluoro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; and N-(5-ethynyl-2-fluorophenyl)-5-chloro-6,7-bis(2-methoxyethoxy)quinazolin-4-amine.