Patent ID: 8775094

Claim:
A computerized method of identifying one or more regions in the amino acid sequence of a protein which are predicted to promote aggregation, wherein said protein is a structured or partially structured protein, the method comprising: determining, for amino acid positions (i) along said sequence, a local propensity for aggregation (A i ) at a said amino acid position, said local propensity for aggregation being determined by a combination of a hydrophobicity value, an α-helix propensity value, a β-sheet propensity value, a charge value and a pattern value for said amino acid position; determining local structural stability values for said amino acid positions, a said local structural stability value comprising a measure of propensity of said folded protein at a said amino acid to remain in a folded state; combining, by one or more processors of a computer performing the method said determined local propensities for aggregation at said amino acid positions and said local structural stability values at said amino acid positions to identify one or more regions in said amino acid sequence which, in said structured or partially structured protein, are predicted to promote aggregation; and outputting a result to at least one of an output device and a memory.