Patent ID: 7805193

Claim:
An implantable device for delivering cardiac therapy to a patient, comprising: one or more pulse generators for generating pacing pulses and neural stimulation pulses; a parasympathetic stimulation channel for stimulating parasympathetic nerve activity by delivering neural stimulation pulses; a sensor for measuring cardiac output; a controller for controlling the delivery of pacing pulses to one or more ventricular sites during a cardiac cycle in accordance with a programmed pacing mode; wherein the controller is programmed to deliver remodeling control therapy (RCT) by controllably delivering ventricular pacing in a manner which pre-excites a region of the ventricular myocardium so as to mechanically unload that region during systole; wherein the controller is further programmed to deliver anti-remodeling therapy (ART) by controlling stimulation of parasympathetic nerve activity via the parasympathetic stimulation channel; wherein the controller is programmed to perform an assessment of cardiac function and to modulate the delivery of RCT and ART in accordance with the assessment of cardiac function, wherein the assessment of cardiac function includes the measurement of cardiac output; and, wherein ART is modulated in response to the assessment of cardiac function by varying the amplitude of the neural stimulation pulses.