Patent ID: 8404818

Claim:
A substantially pure polypeptide comprising a fully human or humanized chimpanzee monoclonal antibody that binds A33 antigen, wherein said monoclonal antibody comprises: (a) heavy chain CDR1 region having the amino acid sequence of SEQ ID NO:35, a heavy chain CDR2 region having the amino acid sequence of SEQ ID NO:37, a heavy chain CDR3 region having the amino acid sequence of SEQ ID NO:39, a light chain CDR1 region having the amino acid sequence of SEQ ID NO:43, a light chain CDR2 region having the amino acid sequence of SEQ ID NO:45 and a light chain CDR3 region having the amino acid sequence of SEQ ID NO:47; or (b) heavy chain CDR1 region having the amino acid sequence of SEQ ID NO:51, a heavy chain CDR2 region having the amino acid sequence of SEQ ID NO:53, a heavy chain CDR3 region having the amino acid sequence of SEQ ID NO:55, a light chain CDR1 region having the amino acid sequence of SEQ ID NO:59, a light chain CDR2 region having the amino acid sequence of SEQ ID NO:61 and a light chain CDR3 region having the amino acid sequence of SEQ ID NO:63.