Patent ID: 7476686

Claim:
A compound of Formula 1 or a pharmaceutically acceptable salt thereof, wherein A 1 is an optionally substituted 6- membered heteroaryl group, an optionally substituted bicyclic heteroaryl group having a 5-membered heteroaryl ring fused to a phenyl ring, an optionally substituted partially unsaturated or aromatic heterocyclic group having two 6-membered rings, an optionally substituted 5- to 7-membered heterocycloalkyl group containing at least one nitrogen atom and 0 or 1 additional heteroatoms, an optionally substituted partially unsaturated 5- to 7-membered heterocycloalkyl group containing at least one nitrogen atom and 0 or 1 additional heteroatoms, a 6-membered heterocycloalkyl group fused to a phenyl or heteroaryl ring, or a fused or spiro 8 to 11-membered bicyclic heterocycloalkyl group containing at least one nitrogen atom and 0 to 3 additional heteroatoms; A2is t is 0 or 1; X is O, S, NR, or absent, where R is hydrogen, optionally substituted C 1 -C 6 alkyl, or optionally substituted aryl(C 0 -C 4 alkyl); Y is C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 3 -C 7 cycloalkyl, or absent; Z is carbonyl or thiocarbonyl; R 1 and R 2 are independently hydrogen, or R 1 and R 2 are independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, each of which is substituted with 0 to 3 substituents independently chosen from halogen, hydroxy, amino, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, or R 1 and R 2 are joined to form a 5- to 7-membered saturated or mono-unsaturated ring optionally containing one additional heteroatom chosen from N, S, and O, which 5- to 7-membered saturated or mono-unsaturated ring is substituted with 0 to 3 substituents independently chosen from halogen, hydroxy, amino, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloallcyl, and C 1 -C 2 haloalkoxy; R 10 is C 1 -C 6 alkyl; R 11 and R 12 each represent 0 to 3 substituents independently chosen from halogen, hydroxy, cyano, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, mono- and di-(C 1 -C 6 alkyl)amino, C 2 -C 6 alkanoyl, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and phenyl; and R 13 and R 14 are independently chosen at each occurrence from hydrogen and C 1 -C 4 alkyl; R 15 is C 4 -C 6 alkoxy or C 4 -C 6 alkyl; R 17 represents 0 to 2 substituents independently chosen from halogen, methyl, and methoxy.