Patent ID: 8569297

Claim:
A method for treating a disease based on the expression of MCP-1 or CX3CR1, comprising administering an effective amount of a compound represented by formula (I): wherein: A is —X 1 — or —X 1 —O—X 2 —, in which X 1 is an alkylene group having from 1 to 5 carbon atoms, optionally substituted with one or more alkyl groups having from 1 to 5 carbon atoms or one or more alkoxy groups having from 1 to 3 carbon atoms, and X 2 is an alkylene group having from 1 to 5 carbon atoms, optionally substituted with one or more alkyl groups having from 1 to 5 carbon atoms, Y is hydrogen, —OH, —N(R 11 )(R 12 ), or —N(R 11 )O(R 12 ), wherein R 11 is hydrogen, an alkyl group having from 1 to 5 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms, or R 11 together with R 12 forms a 4- to 7-membered heterocycle, R 12 is hydrogen, an alkyl group having from 1 to 5 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, an aryl group, a heteroaryl group, an alkylaryl group, an alkylheteroaryl group, —COR′, —COOR′, or —CON(R′)(R″), wherein R′ and R″, which may be identical or different from each other, are each independently hydrogen or an alkyl group having from 1 to 5 carbon atoms, or R 12 together with R 11 , forms a 4- to 7-membered heterocycle, R 1 and R 2 , which may be identical or different from each other, are each independently hydrogen or an alkyl group having from 1 to 5 carbon atoms, R 3 , R 4 and R 8 , which may be identical or different from each other, are each independently hydrogen, an alkyl group having from 1 to 5 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, a halogen atom, —OH, —N(R′)(R″), —N(R′)COR″, —CN, CONR′R″, —SO 2 NR′R″, —SO 2 R′, nitro or trifluoromethyl; wherein R′ and R″, which may be identical or different from each other, are each independently hydrogen or an alkyl group having from 1 to 5 carbon atoms, R 5 is hydrogen, an alkyl group having from 1 to 5 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, a halogen atom, —OH, —N(R′)(R″), —N(R′)COR″, nitro or trifluoromethyl, or R 5 together with one of either R 6 or R 7 forms a ring having 5 or 6 carbon atoms; wherein R′ and R″, which may be identical or different from each other, are each independently hydrogen or an alkyl group having from 1 to 5 carbon atoms, R 6 and R 7 , which may be identical or different from each other, are each independently hydrogen or an alkyl group having from 1 to 5 carbon atoms, or R 6 and R 7 together form a group C═O, or one of either R 6 or R 7 , together with R 5 , forms a ring having 5 or 6 carbon atoms, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, to a subject in need thereof.