Patent ID: 7714018

Claim:
A compound according to formula I wherein: X 1 is —C(═O)R 3 or —S(═O) 2 R 3 ; X 2 is —C(═O)R 4 or —S(═O) 2 R 4 ; R 2 is phenyl optionally substituted with one to four substituents selected independently in each incidence from the group consisting of halogen, C 1-6 alkyl and C 1-6 alkoxy and R 1 is hydrogen; R 3 is selected from the group consisting of: (i) phenyl optionally substituted with one to four substituents selected independently in each incidence from the group consisting of: (a) C 1-10 alkyl, (b) C 1-10 heteroalkyl, (c) C 1-6 haloalkyl, (d) C 1-6 alkoxy, (f) amino, (g) C 1-6 alkyl amino, (h) C 1-6 dialkylamino, (g) C 1-6 acylamino, (i) carbamoyl, N—C 1-6 alkylcarbamoyl or N,N—C 1-4 dialkylcarbamoyl, (j) ureido, (k) nitro, (l) cyano, (m) halogen, (n) C 1-6 alkylsulfonyl, (o) sulfamoyl, N—C 1-6 alkylsulfamoyl or N,N—C 1-6 dialkylsulfamoyl, (p) C 1-6 alkylsulfonamido or optionally substituted phenylsulfonamido, (q) optionally substituted phenoxy, (r) Y(CH 2 ) n R 11 wherein R 11 is selected from the group consisting of cyano, —CO 2 R 12 , CONR 12 R 13 , —SO 2 NR 12 R 13 , —NHSO 2 R 12 and —NHSO 2 NR 12 R 13 , (s) CO 2 R 12 , (t) C 1-6 alkyloxy, (u) C 1-6 alkylcarbonyl, and, (v) C 1-6 haloalkoxy; (ii) phenyl C 1-6 alkyl wherein phenyl as described in (i) above; (ii) C 3-7 cycloalkyl or [3.1.0]bicyclohexyl, 4-oxo-cyclohexyl or 3-oxo-cyclobutyl said cycloalkyl optionally substituted with 1 to 4 fluorine, cyano, hydroxyl, C 1-3 alkyl or phenyl; (iv) C 1-3 alkyl-C 3-7 cycloalkyl said cycloalkyl optionally substituted with 1 to 4 fluorine, C 1-3 alkyl or phenyl; and, (v) NR 14a R 14b ; R 4 is phenyl optionally substituted with one to four substituents selected independently in each incidence from the group consisting of a phenyl substituent (i)(a) to (i)(v) as described in R 3 ; R 5 and R 5a are independently hydrogen or C 1-6 alkyl; R 6 is hydrogen; R 12 and R 13 are independently hydrogen, C 1-6 alkyl or C 1-6 heteroalkyl; R 14a and R 14b are independently hydrogen, optionally substituted phenyl or C 1-6 alkyl; R 14c is hydrogen or C 1-6 alkyl; Y is a direct bond, —O—, —S— or —NR 12 —; n is an integer from 1 to 6; and, pharmaceutically acceptable salts and stereoisomers thereof.