Patent ID: 7045535

Claim:
A compound represented by one of the formulas: wherein X is selected from the group consisting of: CHR, O, NR, N—OR, NR(O), S, S(O) and S(O)O X 1 is selected from the group consisting of CR, N, and N(O); R is selected from the group consisting of: H, alkyl, alkene, alkyne, CN, NO 2 , N 3 , halo and NHR 10 ; R 1 is selected from the group consisting of: H, (CH 2 )nCO 2 R 10 , (CH 2 )n-tetrazol, (CH 2 )nSO 3 H, (CH 2 )nSO 2 H, (CH 2 )nPO 3 H 2 , (CH 2 )nCONR 10 R 10a , (CH 2 )nNO 2 , and (CH 2 )nCHO; R 1a is selected from the group consisting of: H, (CH 2 )nOR 10 , (CH 2 )nCN, (CH 2 )nNR 10 R 10a , (CH 2 )nNHC(O)R 10 , (CH 2 )nC(O)NR 10 R 10a , and (CH 2 )nOC(O)R 10 ; R 1 and R 1a both cannot be H each of R 2 and R 2a is independently selected from the group consisting of H, halo, CN, (CH 2 )nCO 2 R 10 , (CH 2 )nNR 10 R 10a and (CH 2 ) n —OR 10 ; each of R 3 and R 3a is independently selected from the group consisting of: H, NHSO 2 R 10 , N(O)—SO 2 R 10 , NR 10 SO 2 R 10a , (CH 2 )mYR 10 , and (CH 2 )mR 6 ; provided that when R 3 or R 3a is (CH 2 ) m YR 10 or (CH 2 ) m R 6 than m is at least 1 for R 3 or R 3a ; at least one of R 3 and R 3a is other than H Y is selected from the group consisting of: O, NH, NHC(O), C(O)NH, S, S(O), S(O)O, NHS(O)O, S(O)ONH, NHC(O)NH and heterocycle; R 3 and R 3a together may be ═O, ═CHR 6 , ═CHR 10 , ═NR 10 , and ═N—OR 10 R 4 is (CH 2 ) m YR 10 , R 4a is selected from the group consisting of: H, (CH 2 ) mYR 10 , and (CH 2 ) mR 6 R 4 and R 4a together may be: ═O, ═CHR 6 , ═CHR 10 , ═NR 10 and ═N—OR 10 each of R 5 and R 5a is independently selected from the group consisting of C(R 7 )(R 7a )H, C(R 7 )(R 7a )C(R 8 )(R 8a )H, C(R 7 )(R 7a )C(R 8 )(R 8a )C(R 9 )(R 9a )H, OC(R 7 )(R 7a )H, OC(R 7 )(R 7a )C(R 8 )(R 8a )H, C(R 7 )(R 7a )OC(R 8 )(R 8a )H, N(R 10 )C(R 7 )(R 7a )H, N(R 10 ) C(R 7 )(R 7a )C(R 8 )(R 8a )H, C(R 7 )(R 7a )N(R 10 )C(R 8 )(R 8a )H, and C(O)NR 10 R 10a ; R 6 is selected from the group consisting of H, halo, CN, NO 2 , N 3 , CO 2 R 10 , R 10 and NR 10 R 10a ; each R 7 , R 7a , R 8 , R 8a , R 9 and R 9a is individually selected from the group consisting of: H, (CH 2 )mYR 10 and (CH 2 )mR 6 R 7a is (CH 2 )mYR 10 each of the R 10 and R 10a is individually selected from the groups consisting of: H, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl; Each of m and n is individually 0, 1, 2, 3, or 4; and pharmaceutically acceptable salt thereof; and prodrugs thereof.