Patent ID: 6908989

Claim:
A process for the production of perbenzylated 1-O-glycosides of formula I in which sugar 1 is a monosaccharide that is functionalized in 1-OH-position, R represents benzyl, n means 2, 3 or 4, X means —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C 1 -C 30 carbon chain, which optionally is interrupted by 1-10 oxygen atoms, 1-3 sulfur atoms, 1-2 phenylene groups, 1-2 phenylenoxy groups, 1-2 phenylenedioxy groups, a thiophene radical, pyrimidine radical or pyridine radical, and/or optionally is substituted with 1-3 phenyl groups, 1-3 carboxyl groups, 1-5 hydroxy groups, 1-5 O—C 1 -C7 alkyl groups, 1-3 amino groups, 1-3 CF 3 groups or 1-10 fluorine atoms or their salts, said process comprising reacting a perbenzylated 1-OH-sugar of formula II in which sugar 1 , R and n have the indicated meaning, with an alkylating reagent of formula (III) Nu-L-X-Sg (III), in which Nu means a nucleofuge, L and X have the above-mentioned meaning, and Sg represents a protective group, in the organic solvent diethoxymethane in the presence of a base and optionally a phase transfer catalyst at a temperature of 0-50° C., cleaving the protective group and optionally converting reaction product obtained into a salt.