Patent ID: 7235586

Claim:
A method of treating ocular hypertension which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a compound represented by formula I: wherein the wavy segments indicate either the α or β configuration; the dashed bond represents a double bond or a single bond; wherein W is halogen; Z is O or S; Ar is selected from the group consisting of aryl or heteroaryl radicals having from 4 to 10 carbon atoms and substituted derivatives of said aryl and heteroaryl radicals; n is 0 or an integer of from 1 to 4; x and y are 1 or 0, provided that when x is 1, y is 0 and when x is 0, y is 1; R 1 is hydrogen or a lower alkyl radical or a substituted lower alkyl radical having up to six carbon atoms; X is selected from the group consisting of —OR 1 and —N(R 1 ) 2 ; Y is ═O or represents 2 hydrogen radicals, Z is S or O; wherein the substituent on the lower alkyl, aryl or heteroaryl radical is selected from the group consisting of lower alkyl, hydroxy, lower alkyloxy, halogen, trifluoromethyl (CF 3 ), COR 1 , COCF 3 , SO 2 NR 1 , SO 2 NH 2 , NO 2 and CN and/or the pharmaceutically acceptable salts of said compounds and/or esters.