Patent ID: 7265148

Claim:
A compound having the formula: or a pharmaceutically acceptable salt or ester form thereof; wherein: X is O or NH; R 2 is hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 8 cycloalkyl, C 7 -C 11 bicycloalkyl, arylalkyl, carboxyalkyl, C 6 -C 10 aryl, or heterocycle; or X and R 2 together form an amino acid; R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, C 3 -C 8 cycloalkyl, C 7 -C 11 bicycloalkyl, arylalkyl, carboxyalkyl, C 6 -C 10 aryl, or heterocycle; R 3 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 6 alkoxy, C 3 -C 8 cycloalkyl, or —C(═O)C 1 -C 3 alkyl; R 4 and R 5 are, independently, hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 6 alkoxy, C 3 -C 8 cycloalkyl, or —C(═O)C 1 -C 3 alkyl; or R 4 and R 5 , together, form a phenyl ring; and A is hydrogen, C 6 -C 10 aryl, or heterocycle; wherein each of said alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, phenyl and heterocycle groups or part of groups may be optionally substituted by one, two, three or more substituents.