Patent ID: 8227517

Claim:
A method of administering to a subject in need thereof an effective amount of a doxorubicin active agent, said method comprising: administering to said subject said effective amount of a doxorubicin active agent that is an anthracycline antibiotic in conjunction with an amount of a doxorubicin toxicity-reducing adjuvant effective to reduce toxicity of said doxorubicin active agent, wherein said doxorubicin toxicity-reducing adjuvant is a nitrone compound of formula (II): or a pharmaceutically acceptable salt thereof, or a spatial isomer thereof; wherein: L is —[C(R 3 ) 2 ]m-X′—[C(R 4 ) 2 ] n —; m is an integer from 0 to 6; n is an integer from 0 to 6; X′ is selected from the group consisting of no atom, NR 2 , O, S, SO and SO 2 ; Cy is selected, from the group consisting of substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloheteroalkyl, bicycloalkenyl, bicycloheteroalkenyl, bicycloaryl, or bicycloheteroaryl ring; R is hydrogen, thiol, or a disulfide conjugate; R 1 is selected from the group consisting of substituted or unsubstituted aliphatic, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaralkyl; R 2 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted aralkyl; R 3 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted aralkyl; R 4 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl, and any two R 3 s may join together to form a cycloalkyl, cycloheteroalkyl ring; and one of R 3 s and one of R 4 s on carbon atoms adjacent to X′ may join together to form a heterocyclic ring of 5-7 atoms.