Patent ID: 7632839

Claim:
The compound of the formula II: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein one of X and Y is N and the other of X and Y is CH; a is 0 or 1; b is 0 or 1; p is 0 to 3; r is 0 or 1; s is 0 or 1; R 2 is selected from: 1) hydrogen, 2) C 1 -C 10 alkyl, said alkyl is optionally substituted with one or more substituents selected from R 5 ; R 3 is independently selected from: 1) (C═O) a O b C 1 -C 10 alkyl, 2) (C═O) a O b aryl, 3) halo, 4) OH, 5) O b C 1 -C 6 perfluoroalkyl, 6) (C═O) a NR 6 R 7 , 7) CN, 8) (C═O) a O b C 3 -C 9 cycloalkyl, 9) (C═O) a O b heterocyclyl, 10) SO 2 NR 6 R 7 , and 11) SO 2 C 1 -C 10 alkyl, said alkyl, aryl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 5 ; R 4 is independently selected from: 1) H; 2) (C═O) a O b C 1 -C 10 alkyl, 3) (C═O) a O b aryl, 4) halo, 5) OH, 6) O b C 1 -C 6 perfluoroalkyl, 7) O a (C═O) b NR 6 R 7 , 8) (C═O) a O b C 3 -C 8 cycloalkyl, 9) SO 2 C 1 -C 10 alkyl, and 10) SO 2 NR 6 R 7 , said alkyl, aryl and cycloalkyl optionally substituted with one or more substituents selected from R 5 ; R 5 is selected from: 1) (C═O) r O s (C 1 -C 10 )alkyl, 2) O r (C 1 -C 3 )perfluoroalkyl, 3) (C 0 -C 6 )alkylene-S(O) m R a , 4) oxo, 5) OH, 6) halo, 7) CN, 8) (C═O) r O s (C 2 -C 10 )alkenyl, 9) (C═O) r O s (C 2 -C 10 )alkynyl, 10) (C═O) r O s (C 3 -C 6 )cycloalkyl, 11) (C═O) r O s (C 0 -C 6 )alkylene-aryl, 12) (C═O) r O s (C 0 -C 6 )alkylene-heterocyclyl, 13) (C═O) r O s (C 0 -C 6 )alkylene-N(R b ) 2 , 14) C(O)R a , 15) (C 0 -C 6 )alkylene-CO 2 R a , 16) C(O)H, 17) (C 0 -C 6 )alkylene-CO 2 H, and 18) C(O)N(R b ) 2 , said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b ) 2 ; R 6 and R 7 are independently selected from: 1) H, 2) (C═O)O b C 1 -C 10 alkyl, 3) (C═O)O b C 3 -C 8 cycloalkyl, 4) (C═O)O b aryl, 5) (C═O)O b heterocyclyl, 6) C 1 -C 10 alkyl, 7) aryl, 8) C 2 -C 10 alkenyl, 9) C 2 -C 10 alkynyl, 10) heterocyclyl, 11) C 3 -C 8 cycloalkyl, 12) SO 2 R a , and 13) (C═O)NR b 2 , said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 5 , or R 6 and R 7 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 4-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 5 ; R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and R b is H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-NR a 2 , (C 1 -C 6 )alkyl-NH 2 , (C 1 -C 6 )alkyl-NHR a , aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O)OC 1 -C 6 alkyl, (C═O)C 1 -C 6 alkyl or S(O) 2 R a .