Patent ID: 7030139

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof; wherein R 1 is selected from the group consisting of —(C 1 –C 8 )alkyl, —(C 2 –C 8 )alkenyl, R 4 2 N(C 1 –C 6 )alkyl-, R 4 2 NC(═O)(C 1 –C 6 )alkyl-, R 4 O(C 1 –C 6 )alkyl-, R 4 OC(═O) (C 1 –C 6 )alkyl-, R 4 C(═O)(C 1 –C 6 )alkyl-, R 4 C(═O)NR 4 (C 1 –C 6 )alkyl-, R 4 2 NSO 2 (C 1 –C 6 )alkyl-, R 4 CSO 2 NR 4 (C 1 –C 6 )alkyl-, R 4 2 NC(═O)NR 4 (C 1 –C 6 )alkyl-, R 4 2 NSO 2 NR 4 (C 1 –C 6 )alkyl-, aryl(C 1 –C 6 )alkyl, aroyl(C 1 –C 6 )alkyl, (C 3 –C 8 )heterocycloalkyl(C 1 –C 6 )alkyl, bicyclic heteroaryl (C 1 –C 6 )alkyl and bicyclic heteroaroyl(C 1 –C 6 )alkyl; wherein said —(C 2 –C 8 )alkenyl, —(C 1 –C 8 )alkyl of R 1 are unsubstituted or substituted by one or more moieties independently selected from the group consisting of halogen, cyano, acetoxymethyl, and nitro; Ar is an optionally substituted aryl moiety; R 2 is —(C 1 –C 6 )alkyl, unsubstituted or substituted on 1–6 carbons by one or more fluorine substituents, or (C 3 –C 6 )cycloalkyl; R 3 is selected from the group consisting of: R 4 is a moiety independently selected from the group consisting of —H, —(C 1 –C 6 )alkyl, —(C 2 –C 6 ) alkenyl and —(C 2 –C 6 )alkynyl; R 5 moieties are independently selected from the group consisting of —H, —(C 1 –C 6 )alkyl, —(C 2 –C 6 )alkenyl and heterocyclyl; R 6 moieties are independently selected from the group consisting of: —H, —(C 1 –C 6 )alkyl, —(C 2 –C 6 )alkenyl, —(C 1 –C 6 )alkanoyl, heterocyclyl, heterocyclyl (C 1 –C 3 )alkyl, aryl, aryl(C 1 –C 3 )alkyl, bicyclic heteroaryl, and bicyclic heteroaryl(C 1 –C 3 )alkyl; with a proviso that: when R 3 is (b) or (i), R 6 is not —(C 1 –C 6 )alkyl; when R 3 is (j), —R 5 are not both —H; R 5 and R 6 may combine to form a 5–7 membered heterocycle; X is selected from the group consisting of —C(R 5 ) 2 —, —NR 5 —, C(═O )—, —CH 2 —CH 2 —, —CH═CH—, —O—, —C(R)(R′)—, and —S(O) n —(where n=0, 1 or 2), where R and R′=(C 1 –C 6 )alkyl, OR″, or II, and R″=H or (C 1 –C 6 )alkyl; and Y is CH; and wherein if R 1 represents R 4 2 N(C 1 –C 6 )alkyl-, wherein both occurrences of R 4 represent —(C 1 –C 6 )alkyl, then R 3 is not acetyl, —NH 2 , or acetamido.