Patent ID: 7053106

Claim:
A method for lowering blood glucose levels or for treating diabetes, which comprises administering to a patient in need of treatment a therapeutically effective amount of a compound which has the structure wherein x is 1, 2, 3 or 4; n is 1 or 2; n is 1 or 2; Q is C or N; A is O or S; Z is O or a bond; R 1 is H or lower alkyl; X is CH or N; with the proviso that where Z is O then Q is N or A is S or X is N; R 2 is H, alkyl, alkoxy, halogen, amino or substituted amino; R 2a , R 2b and R 2c are the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino; R 3 is aryloxycarbonyl, alkyloxycarbonyl, alkynyloxycarbonyl, alkenyloxycarbonyl, alkyl(halo)aryloxycarbonyl, alkyloxy(halo)aryloxycarbonyl cycloalkylaryloxycarbonyl, cycloalkyloxyaryloxycarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, alkoxycarbonylamino, aryloxycarbonylamino, heteroaryloxycarbonylamino, alkylsulfonyl, alkenylsulfonyl, heteroaryloxycarbonyl, cycloheteroalkyloxycarbonyl, heteroarylalkenyl, hydroxyalkyl, alkoxy, alkoxyaryloxycarbonyl, arylalkyloxycarbonyl, alkylaryloxycarbonyl, alkynyloxycarbonyl, haloalkoxyaryloxycarbonyl, alkoxycarbonylaryloxycarbonyl, aryloxyaryloxycarbonyl, arylalkenyloxycarbonyl, heteroaryloxyarylalkyl, aryloxyarylalkyloxycarbonyl, aryloxyalkyloxycarbonyl, arylalkylsulfonyl, arylthiocarbonyl, arylalkenylsulfonyl, heteroarylsulfonyl, arylsulfonyl, heteroarylalkoxycarbonyl, heteroarylalkyloxyarylalkyl, arylalkenylarylalkyl, arylalkoxycarbonylheteroarylalkyl, heteroaryloxyarylalkyl, arylalkenylheteroarylalkyl or polyhaloalkylaryloxycarbonyl; Y is CO 2 R 4 were R 4 is H or alkyl, or a prodrug ester or Y is a C-linked 1-tetrazole, a phosphinic acid of the structure P(O)(OR 4a )R 5 where R 4a is H or a prodrug ester, R 5 is alkyl or aryl or a phosphonic acid of the structure P(O)(OR 4a ) 2 where R 4a is H or a prodrug ester; or stereoisomers thereof, a prodrug ester thereof and or a pharmaceutically acceptable salt thereof.