Patent ID: 6967022

Claim:
A composition which comprises: (a) a conjugate of (i) a derivative of a GD3 lactone ganglioside, which GD3 lactone ganglioside comprises an unaltered sphingosine base, wherein the derivative differes from the Gd3 lactone ganglioside solely by having an altered sphingosine base which retains only C1 through C4 from the unaltered sphingosine base of the GD3 lactone ganglioside, and (ii) Keyhole Limpet Hemocyanin, wherein the GD3 lactone ganglioside derivative is covalently bound to Keyhole Limpet Hemocyanin by a stable amine bond between the C-4 carbon of the altered sphingosine base and nitrogen of an ε-aminolysyl group of Keyhole Limpet Hemocyanin; (b) QS-21; and (c) a pharmaceutically acceptable carrier, wherein the amount of the conjugated GD3 lactone derivative is an amount between about 1 μg and about 200 μg, the amount of QS-21 is an amount between about 10 μg and about 200 μg, the GD3 lactone derivative:Keyhole Limpet Hemocyanin molar ratio is from 200:1 to 1400:1, the relative amounts of such conjugate and QS-21 is effective to stimulate or enhance production in a subject of an antibody to the GD3 lactone ganglioside.