Patent ID: 8530506

Claim:
A production method of a biaryltetrazole derivative represented by the formula [I]: wherein X 2 is a halogen atom, and R 1 is a tetrazolyl-protecting group selected from a C 7-19 aralkyl group, a substituted C 7-19 aralkyl group and a trialkylsilyl group, or a salt thereof, which comprises 1) reacting an aryltetrazole derivative represented by the formula [II]: wherein R 1 is as defined above with a benzene derivative represented by the formula [III]: wherein R 2 is a methyl group, a methyl group substituted by hydroxyl group(s) protected by a protecting group, or a lower alkoxycarbonyl group, and X 1 is a leaving group selected from a halogen atom, a C 6-10 arylsulfonyloxy group optionally substituted by 1 to 3 C 1-6 alkyl groups and a C 1-6 alkylsulfonyloxy group optionally substituted by 1 to 3 halogen atoms in the presence of a ruthenium catalyst, a ligand and a base; 2) in the obtained compound represented by the formula [IV]: wherein the symbols are as defined above, (a) deprotecting the compound wherein R 2 is a methyl group substituted by hydroxyl group(s) protected by a protecting group, or (b) reducing the compound wherein R 2 is a lower alkoxycarbonyl group, to give a compound represented by the formula [V]: wherein the symbol is as defined above; and 3) halogenating the compound represented by the formula [IV] wherein R 2 is a methyl group, or the compound represented by the formula [V] when R 2 in the compound represented by the formula [IV] is a methyl group substituted by hydroxyl group(s) protected by a protecting group, or a lower alkoxycarbonyl group.