Patent ID: 7576099

Claim:
A compound according to formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, wherein: each of W, Z and X is CR 4 and Y is CR 4″ ; L is —(CR 5 ═CR 6 )— or —(C≡C)—; R 1 is quinolinyl substituted with hydrogen, C 1 -C 6 alkyl, hydroxyl C 1 -C 6 alkyl, C 1 -C 6 alkylamino, C 1 -C 6 alkoxy, amino C 1 -C 6 alkoxy, substituted amino C 1 -C 6 alkoxy, di C 1 -C 6 alkylamino C 1 -C 6 alkoxy, cycloalkyl C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkylarylamino, aryl C 1 -C 6 alkyloxy, amino, aryl, aryl C 1 -C 6 alkyl, substituted sulfonyl, sulfanyl, aminosulfonyl, arylsulfonyl, azido, carboxy, carbamoyl, cyano, cycloheteroalkyl, di C 1 -C 6 alkylamino, halo, heteroaryloxy, heteroaryl, heteroalkyl, hydroxyl, nitro or thio; R 3 is CR 6′ R 7 R 8 ; each R 4 is independently hydrogen, C 1 -C 6 alkyl, hydroxyl C 1 -C 6 alkyl, C 1 -C 6 alkylamino, C 1 -C 6 alkoxy, amino C 1 -C 6 alkoxy, substituted amino C 1 -C 6 alkoxy, di C 1 -C 6 alkylamino C 1 -C 6 alkoxy, cycloalkyl C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkylarylamino, aryl C 1 -C 6 alkyloxy, amino, aryl, aryl C 1 -C 6 alkyl, substituted sulfonyl, sulfanyl, aminosulfonyl, arylsulfonyl, azido, carboxy, carbamoyl, cyano, cycloheteroalkyl, di C 1 -C 6 alkylamino, halo, heteroaryloxy, heteroaryl, heteroalkyl, hydroxyl, nitro or thio; R 4″ is substituted alkyl, methyl, halo, substituted sulfonyl, alkoxy, or amino; each of R 5 and R 6 is independently H, halo, or C 1 -C 6 alkyl; and R 6′ is hydrogen, halo or C 1 -C 6 alkyl; each of R 7 and R 8 is independently halo or C 1 -C 6 alkyl; or R 7 and R 8 together form a C 3 -C 8 cycloalkyl ring.