Patent ID: 8470358

Claim:
A medical device comprising a polymer and a metal complex, the metal complex comprising a metal and at least one ligand, wherein: the polymer forms the medical device or a coating of the medical device; the at least one ligand of the metal complex covalently attaches to a surface of the medical device or the coating on the medical device via a spacer, the spacer is a phenyl group, an aryl group, a short chain peptide, a biocompatible oligomer, or a biocompatible polymer functionalized by a reactive group selected from the group consisting of carboxyl, hydroxyl, thiol, amine, acid halide, N-hydroxysuccinimide, acryloyl, and Vinyl sulfone, the polymer is copolymer of monomers selected from 2-hydroxyethyl methacrylate (HEMA), hydroxypropyl methacrylate (HPMA), hydroxypropylmethacrylamide, PEG acrylate (PEGA), PEG methacrylate, 2-methacryloyloxyethylphosphorylcholine (MPC), methacrylic acid (MA), and acrylic acid (AA); the metal complex catalyzes the generation of nitric oxide in the blood stream or a tissue adjacent to the medical device; and the medical device is a non-degradable polymer stent.