Patent ID: 7053122

Claim:
A method of treating a disease selected from faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, neuropathic pain, sleep disorders and neuropathological disorders in a mammal, comprising administering to said mammal a compound or a pharmaceutically acceptable salt thereof of formula (I): wherein R 1 is H, C 1 –C 6 alkyl or C 3 –C 8 cycloalkyl; X is —(CH 2 ) n —C(R 7 )(R 8 )—; Y is a direct link or —(CH 2 ) m —C(R 9 )(R 10 )—; R 7 , R 8 , R 9 and R 10 are independently H or C 1 –C 6 alkyl; or R 8 and R 1 can be taken together with the nitrogen to which R 1 is attached to form a 4–8-membered heterocycloalkyl ring; or R 10 and R 1 can be taken together with the nitrogen to which R 1 is attached to form a 4–8-membered heterocycloalkyl ring; or R 8 and R 10 can be taken together with the carbons to which they are attached to form a 4–8-membered carbocyclic ring; n is 0, 1 or 2; m is 0, 1 or 2; R 2 , R 3 , R 4 and R 5 are independently selected from H, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, hydroxy, halogen, hydroxycarbonyl, C 1 –C 6 alkoxycarbonyl, cyano, sulfonyl, C 1 –C 6 alkylsulfonyl, thio, C 1 –C 6 alkylthio, sulfonamide, perfluoro-C 1 –C 6 alkyl, perfluoro-C 1 –C 6 alkoxy, C 3 –C 8 cycloalkyl, 4–8 membered heterocycloalkyl, amino, (C 1 –C 6 alkyl or di-C 1 –C 6 alkyl)amino, aminocarbonyl, (C 1 –C 6 alkyl or di-C 1 –C 6 alkyl)aminocarbonyl, C 1 –C 6 acylamino, (N—C 1 –C 6 alkyl)C 1 –C 6 acylamino, phenyl or monocyclic heteroaryl, wherein phenyl and monocyclic heteroaryl are optionally substituted with C 1 –C 6 alkyl, C 1 –C 6 alkoxy, hydroxy, halogen, hydroxycarbonyl, C 1 –C 6 alkoxycarbonyl or perfluoro-C 1 –C 6 alkoxy; or any one or two of CR 2 , CR 3 , CR 4 and CR 5 may be replaced with a nitrogen; or R 2 and R 3 or R 3 and R 4 or R 4 and R 5 may be taken together with the carbons to which they are attached to form fused C 5 –C 8 cycloalkyl, 4–8 membered heterocycloalkyl, phenyl or monocyclic heteroaryl; or R 1 and R 2 can be taken together with the nitrogen to which R 1 is attached to form a 4–8-membered heterocycloalkyl ring; or R 8 and R 2 can be taken together with the carbons to which they are attached to form a 4–8-membered carbocyclic or heterocycloalkyl ring; and R 6 is hydroxycarbonyl or a carboxylic acid biostere or a prodrug thereof.