Patent ID: 7488724

Claim:
A compound of formula (I): wherein: R 1 and R 2 are each independently hydrogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyl, (C 1 -C 10 )alkanoyloxy, (C 1 -C 10 )alkoxycarbonyl, aryl, heterocycle, halo, cyano, nitro, —COOR e , —C(═O)NR f R g ,—OC(═O)NR f R g , NR f R g , or —S(O) n R h ; R 3 is —CH═CHC(═O)NR m R p ; R 4 is hydrogen; A is thio, sulfinyl, or sulfonyl; each n is independently 0,1, or 2; each R e is independently hydrogen, or (C 1 -C 10 )alkyl; each R f and R g is independently hydrogen, (C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy, phenyl, benzyl, phenethyl, (C 1 -C 10 )alkanoyl, or —C(═O)NQ; wherein Q and the N atom to which it is attached forms a ring containing 2-20 carbon atoms, optionally containing a nitrogen atom in the ring —NR e —; each R h is independently (C 1 -C 10 )alkyl, phenyl, aryl(C 1 -C 6 )alkyl, heteroaryl, heterocycle, or heterocycle(C 1 -C 6 )alkyl; and R i is hydrogen or (C 1 -C 6 )alkyl; and R m is hydrogen, and R p is NH 2 , OH, (C 3 -C 10 )cycloalkyl, or —(C 2 -C 10 )alkyl-NH 2 ; or R m and R p together with the nitrogen to which they are attached form a piperidine, morpholine, thiomorpholine, pyrrolidine, or a piperazine ring; wherein any (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyl, (C 1 -C 10 )alkanoyloxy, or (C 1 -C 10 )alkoxycarbonyl of R 1 or R 2 is optionally substituted with one or more, substituents independently selected from halo, hydroxy, cyano, cyanato, nitro, mercapto, oxo, aryl, heterocycle, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, aryl(C 1 -C 6 )alkanoyloxy, halo(C 1 -C 6 )alkanoyloxy, heterocycle(C 1 -C 6 )alkanoyloxy, aryloxy, (heterocycle)oxy, (C 3 -C 8 )cycloalkyl, —COOR e , —C(═O)NR f R g ,—OC(═O)NR f R g , —NR h R i , or —S(O) n R h ; and wherein any aryl is optionally substituted with one or more substituents independently selected from halo, hydroxy, cyano, trifluoromethyl, nitro, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl,—COOR e , —C(═O)NR f R g , —OC(═O)NR f R g , NR h R i , or —S(O) n R h ; or a pharmaceutically acceptable salt thereof.