Patent ID: 8097719

Claim:
A method for preparation of meropenem trihydrate having the structure from a protected meropenem of the structure comprising the steps of: deprotecting the protected meropenem of Formula I by hydrogenation at an atmospheric pressure at a temperature between and including 30° C. and 35° C. in at least one water miscible solvent selected from the group consisting of acetone, methanol, tetrahydrofuran, ethanol or a mixture thereof, at a pH 6.5 to 6.9; in the deprotection reaction the pH of reaction mass is in 6.5 to 6.9 maintained by using an aqueous solution of sodium carbonate or a phosphate buffer or a morpholine buffer of pH of 7; degasifying and charcoalizing the reaction mass followed by adding acetone at a temperature between and including 0° C. and 5° C. in order to obtain meropenem trihydrate.