Patent ID: 7855270

Claim:
A recombinant receptor comprising: an extracellular ligand binding domain derived from a receptor; and a cytoplasmic domain derived from a receptor, wherein at least one activation site of said cytoplasmic domain has been inactivated by either mutation, deletion, or mutation and deletion, said cytoplasmic domain comprising at least two parts: a first part derived from a cytoplasmic domain of a receptor and a second part comprising a heterologous bait polypeptide which is heterologous to said cytoplasmic domain of said receptor from which said first part is derived; wherein said cytoplasmic domain comprises at least a JAK binding site; and wherein said recombinant receptor is activated by binding of a ligand to said extracellular ligand binding domain and by binding of a prey polypeptide to said heterologous bait polypeptide; and wherein said heterologous bait polypeptide is modified by a modification selected from the group of modifications consisting of phosphorylation, acetylation, acylation, methylation, ubiquitinilation, glycosylation, and proteolytic cleavage; wherein said modification of the heterologous bait polypeptide occurs before binding of said heterologous bait polypeptide to said prey polypeptide.