Patent ID: 7935343

Claim:
An isolated specific binding member for human IL-13, comprising an antibody antigen-binding site which is composed of a human antibody VH fragment and a human antibody VL fragment and which comprises a set of CDRs HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein the VH fragment comprises HCDR1, HCDR2 and HCDR3 and the VL fragment comprises LCDR1, LCDR2 and LCDR3, wherein the set of CDRs consists of a set of CDRs comprising: the BAK278D6 set of CDRs, defined wherein the HCDR1 has the amino acid sequence of SEQ ID NO: 1, the HCDR2 has the amino acid sequence of SEQ ID NO: 2, the HCDR3 has the amino acid sequence of SEQ ID NO: 3, the LCDR1 has the amino acid sequence of SEQ ID NO: 4, the LCDR2 has the amino acid sequence of SEQ ID NO: 5, and the LCDR3 has the amino acid sequence of SEQ ID NO: 6, wherein the set of CDRs has a substitution selected from the group consisting of (1) S for N at HCDR3 residue 99; (2) for N at LCDR1 residue 27; or (3) S for N at HCDR3 residue 99 and I for N at LCDR1 residue 27.