Patent ID: 8623378

Claim:
A multi-antigenic glycopeptide comprising a peptidic backbone made up of at least three amino acid residues, wherein two or more of said amino acids are independently: wherein each occurrence of A is a carbohydrate determinant having the structure: wherein a, b, c, d, e, f, g, h, i, x, y and z are independently 0, 1, 2 or 3, with the proviso that the x, y and z bracketed structures represent pyranose moieties and the sum of b and c is 2, the sum of d and f is 2, and the sum of g and i is 2, and with the proviso that x, y and z are not simultaneously 0; wherein R 0 is hydrogen, a linear or branched chain alkyl, acyl, arylalkyl or aryl group; wherein each occurrence of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 is independently hydrogen, OH, OR i , NHR i , NHCOR i , F, CH 2 OH, CH 2 OR i , a substituted or unsubstituted linear or branched chain alkyl, (mono-, di- or tri)hydroxyalkyl, (mono-, di- or tri)acyloxyalkyl, arylalkyl or aryl group; wherein each occurrence of R i is independently hydrogen, CHO, COOR ii , or a substituted or unsubstituted linear or branched chain alkyl, acyl, arylalkyl or aryl group or a saccharide moiety having the structure: wherein Y and Z are independently NH or 0; wherein k, l, r, s, t, u, v and w are each independently 0, 1 or 2; with the proviso that the v and w bracketed structures represent pyranose moieties and the sum of 1 and k is 2, and the sum of s and u is 2, and with the proviso that v and w are not simultaneously 0; wherein R′ 0 is hydrogen, a linear or branched chain alkyl, acyl, arylalkyl or aryl group; wherein each occurrence of R 10 , R 11 , R 12 , R 13 , R 14 and R 15 is independently hydrogen, OH, OR iii , NHR iii , NHCOR iii , F, CH 2 OH, CH 2 OR iii , or a substituted or unsubstituted linear or branched chain alkyl, (mono-, di- or tri)hydroxyalkyl, (mono-, di- or tri)acyloxyalkyl, arylalkyl or aryl group; wherein each occurrence of R 16 is hydrogen, COOH, COOR ii , CONHR ii , a substituted or unsubstituted linear or branched chain alkyl or aryl group; wherein each occurrence of R iii is hydrogen, CHO, COOR iv , or a substituted or unsubstituted linear or branched chain alkyl, acyl, arylalkyl or aryl group; and wherein each occurrence of R ii and R iv are each independently H, or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group; wherein at least one occurrence of A is a carbohydrate determinant having the structure: wherein each occurrence of R′ is independently hydrogen or a protecting group; and wherein R″ is hydrogen or a nitrogen protecting group; wherein each occurrence of n is independently 1-8 and at least one occurrence of A has a different structure from other occurrences of A.