Patent ID: 6900329

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt, or solvate thereof, wherein m is a number from 0 to 3; n is 1; m and n maybe the same or different; X 1 CH, or C—(C 1 -C 3 )alkyl; X 2 is N—R 5 ; X 3 is O or N—R 6 ; X 4 is a single bond, O, N, NH, N—R 7 or when X 4 is N, R 2 and X 4 can join together to form a ring selected from the group consisting of piperidine, pyrrolidine, morpholine, piperazine, thiomorpholine or where the N of X 4 is the heteroatom of said, wherein-said ring can be optionally substituted with one or more alkyl, aryl, aryl, aralkyl, or cycloalkylalkyl; Ar is an arylene or heteroarylene group; R is R 4 -phenyl, R 4 -pyridyl, R 4 -pyridyl-N-oxide, R 4 -pyrazyl or R 4 -pyrimidyl; R 1 is hydrogen, or (C 1 -C 3 )alkyl; R 2 is alkyl, arylalkyl, substituted arylalkyl, cycloalkyl, cycloalkylalkyl, R 8 -phenyl, R 8 -pyridyl, R 8 -pyridyl-N-oxide; R 3 is hydrogen, OH, —O(C 1 -C 3 )alkyl, or non-substituted or halosubstituted (C 1 -C 3 )alkyl; R 4 and R 8 maybe the same or different, may number 0 to 3, each being independently selected from the group consisting of hydrogen, —(C 1 -C 6 )alkyl, —(C 3 -C 7 )cycloalkyl, halo, —CN, (C 1 -C 6 )alkoxy, —CF 3 , —OCF 3 , —CONH 2 , —CONH(C 1 -C 6 )alkyl, —CON(C 1 -C 8 )alkyl (C 1 -C 6 )alkyl, —NH 2 , —NHC(O)(C 1 -C 6 )alkyl, —NHC(O)NH(C 1 -C 6 )alkyl, —NHC(O)N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), —NHSO 2 (C 1 -C 6 )alkyl, —S(C 1 -C 6 )alkyl, —SO(C 1 -C 6 )alkyl, —SO 2 (C 1 -C 6 )alkyl, —SO 2 NH (C 1 -C 6 )alkyl, —O(C 1 -C 3 )alkyleneO—, and NO 2 or two adjacent R 4 or two adjacent R 8 groups together may form a methylenedioxy, propylenedioxy or ethylenedioxy group; R 5 is hydrogen, nonsubstituted or halosubstituted —(C 1 -C 6 )alkyl, nonsubstituted or halosubstituted (C 3 -C 7 )cycloalkyl, nonsubstituted or halosubstituted (C 3 -C 7 )cycloalkyl(C 1 -C 6 )alkyl, nonsubstituted or halosubstituted —(C 1 -C 6 ) alkylene(C 1 -C 6 )alkoxy, nonsubstituted or halosubstituted alkoxycarbonyl, nonsubstituted or halosubstituted aryl, nonsubstituted or halosubstituted heterocycloalkyl, nonsubstituted or halosubstituted heteroaryl, nonsubstituted or halosubstituted aralkyl, nonsubstituted or halosubstituted (C 1 -C 6 )alkylbenzimidazole, nonsubstituted or halosubstituted heteroaralkyl, nonsubstituted or halosubstituted C(O)NH(C 1 -C 3 )alkylene N(R 9 ) 2 , —SO 2 (C 1 -C 6 )alkyl or wherein R 5 is independently selected from, —SO 2 NH 2 , —SO 2 NHalkyl, —SO 2 Nalkyl 2 , R 6 and R 7 may be the same or different, each being independently selected from hydrogen, nonsubstituted or halosubstituted (C 1 -C 3 )alkyl; or R 6 and R 7 can be joined together to form a 4 to 7-membered ring; and R 9 is hydrogen, (C 1 -C 6 ) alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkylmethyl, aralkyl or heteroaralkyl, or the moiety —N(R 9 ) 2 may represent a pyrrolidine, piperazine or piperidine.