Patent ID: 8809326

Claim:
A compound of formula (I) wherein: R 1 is chosen from C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, haloC 1-6 alkyl, aminoC 1-6 alkyl, hydroxyC 1-6 alkyl, aryl, heteroaryl, heteroarylC 1-6 alkyl, heterocyclyl, —C 1-3 alkylOaryl, —CH 2 OC(O)C 1-6 alkyl, (CH 2 ) 1-2 S(O) 0-2 C 1-6 alkyl, —(CH 2 ) 1-3 CO 2 C 1-6 alkyl, —(CH 2 ) 1-3 NHC 1-6 alkyl, —(CH 2 ) 1-3 NH C 1-6 alkylC 3-8 cycloalkyl, —(CH 2 ) 1-2 CN and —CH(R 3 )N(R 4 )(R 5 ) wherein: R 3 is chosen from H, C 1-6 alkyl, —(CH 2 ) 1-3 aryl and —(CH 2 ) 1-3 heteroaryl; R 4 is chosen from H, C 1-6 alkyl, C 3-12 cycloalkyl, C 3-7 cycloalkylC 1-6 alkyl, aryl, aryl(CH 2 ) 1-3 , heteroaryl(CH 2 ) 1-3 , C 1-3 alkylO(CH 2 ) 1-3 , tetrahydropyran-4-ylmethyl and (C 1-3 alkyl) 2 N(CH 2 ) 2-4 —; and R 5 is chosen from H and C 1-6 alkyl; or R 4 and R 5 together with the nitrogen atom they are connected to may form a heterocyclyl group; wherein each aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkylalkyl, cycloalkyl and heterocyclyl group is optionally substituted with 1-3 groups selected from halogen, C 1-6 alkoxy, C 3-8 cycloalkyl, C 1-6 alkyl, —CN, —NO 2 , —OH, oxo, —CF 3 , —OCF 3 , —C 0-3 alkylCO 2 H, C 1-6 alkylCO 2 —, C 1-6 alkylsulfonylC 0-3 alkyl-, SO 2 C 1-6 alkylNR 6 R 7 , —C 0-3 alkylSO 2 NR 6 R 7 , —C 0-3 C(O)NR 6 R 7 , heteroaryl, heteroarylC 1-3 alkyl, heterocyclyl, heterocyclyISO 2 —, arylC 1-3 alkyl, aryloxy, arylthio and C 0-3 NR 6 R 7 ; wherein each aryl and heteroaryl group is optionally substituted with 1-3 groups selected from halogen, C 1-6 alkoxy, C 1-6 alkyl, —CN, —NO 2 , —OH, —CF 3 , —OCF 3 , —C(O)NR 8 R 9 , —SO 2 NR 8 R 9 , —SO 2 Me and amino optionally substituted by one or two C 1-6 alkyl groups or a C(O)C 1-6 alkyl group; R 2 is chosen from H, halogen, C 1-6 alkoxy, —CN, —CF 3 and C 1-6 alkyl; R 6 and R 7 are independently selected from H, C 1-6 alkyl, —C(O)C 1-6 alkyl and —C 1-6 alkylNH 2 ; or R 6 and R 7 , together with the nitrogen they are connected to may form a piperazine, piperidine or pyrrolidine ring; R 8 and R 9 are independently selected from H and methyl; R 10 is selected from H, Cl and F; X is CH; and Y is chosen from —NHC(O)—; or a tautomer or a pharmaceutically acceptable salt of the compound of formula (I).