Patent ID: 6909002

Claim:
A method of preparing a compound of Formula LX Or a pharmaceutically acceptable salt thereof, comprising Step C: reacting, in solvent A, a compound of Formula Va wherein —OR 1 is a suitable leaving group; and solvent A is selected from the group consisting of dimethylacetamide, dimethylformamide, acetonitrile, DMSO, methylacetamide, ethers or mixtures thereof; with a compound of Formula VII or free base thereof, in the presence of a palladium catalyst and a phosphine ligand and a second base to yield a compound of Formula VIII Step D: reacting, in water a compound of Formula VIII with sodium or potassium hydroxide to yield a compound of Formula VIIIa and Step E: reacting, in solvent B, a compound of Formula VIIIa with cyclopropylamine in the presence of an activating agent to yield a compound of Formula IX wherein solvent B is selected from the group consisting of dimethylaminoacetamide, dimethylformamide, acetonitrile, DMSO, methylacetamide, dichloromethane, ethers or mixtures thereof.