Patent ID: 8642727

Claim:
A glucagon-like peptide 2 (GLP-2) analogue represented by the general Formula I: R 1 -Z 1 -His-X2-X3-Gly-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-Phe-Ile-X24-Trp-Leu-Ile-X28-Thr-Lys-X31-X32-X33-Z 2 -R 2 (SEQ ID NO:2) wherein: R 1 is hydrogen, C 1-4 alkyl, methyl, acetyl, formyl, benzoyl or trifluoroacetyl; X2 is Gly, Ala or Sar; X3 is Glu or Asp; X5 is Ser or Thr; X6 is Phe or Pro or a conservative substitution; X7 is Ser or Thr; X8 is Asp or Ser or a conservative substitution; X9 is Glu or Asp or a conservative substitution; X10 is Met, Leu, Nle or an oxidatively stable Met-replacement amino acid; X11 is Y1; X12 is Thr or Lys or a conservative substitution; X13 is Ile, Glu or Gln or a conservative substitutio; X14 is Leu, Met or Nle or a conservative substitution; X15 is Asp or Glu; X16 is Y2; X17 is Leu or Glu or a conservative substitution; X18 is Ala or Aib or a non-conservative substitution; X19 is Ala or Thr or a conservative substitution; X20 is Y3 X21 is Asp or Ile or a conservative substitution; X24 is Y4; X28 is Y5; X31 is Pro, Ile or deleted; X32 is Thr or deleted; X33 is Asp, Asn or deleted; R 2 is NH 2 or OH; wherein Z 1 and Z 2 are independently absent or a peptide sequence of 1-10 amino acid units selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, His, Met and Orn; and the hydrophaticity profile (HPP) of the residues X11, X16, X20, X24, X28 of formula I calculated as HPP=Σ hpi X11 +hpi X16 +hpi X20 +hpi X24 +hpi X28 is ≧−10 wherein Y 1 , Y 2 , Y 4 , and Y 5 can individually be selected from the group consisting of Asn, Asp, Glu, Gln, Lys, His, Arg, Ala, Ser, Thr, Pro, Gly, Leu, Ile, Val, Met or Phe; and Y 3 can be selected from the group consisting of Asn, Asp, Glu, Gln, His, Arg, Ala, Ser, Thr, Pro, Gly, Leu, Ile, Val, Met or Phe; with the proviso that when X20 is Arg then X11 is Ser, X16 is Ala, X24 is Ala, X28 is Ala and Z2 is Lys, or a pharmaceutically acceptable salt thereof and with the proviso that if X15 is Asp then X8 is Ser.