Patent ID: 6849607

Claim:
A compound of the formula: where R 1 is lower alkyl, vinyl, alkyl ether, aryl, lower carboxy, or —CH(OR 9 )CH 3 where R 9 is alkyl of 1 to about 20 carbon atoms, a cyclic containing substituent containing 1 to about 20 carbon atoms connected to the a ring through a carbon-carbon or —O— bond; R 2 and R 5 are independently hydrogen or lower alkyl, R 3 and R 4 are independently —H, lower alkyl, or —OR 10 , where R 10 is H or lower alkyl, or R 3 and R 4 , together form a covalent bond; R 6 and R 7 taken together are ═NR 11 or are independently —OR 11 where R 11 is independently —H, alkyl of 1 to about 20 carbon atoms, a cyclic containing substituent containing 1 to about 20 carbon atoms, an amide group or a mono or polysaccharide connected to ═N— or —O— through at least one of a saturated or unsaturated lower alkylene group, a saturated or unsaturated heterocylic or hydrocarbon five or six membered ring, an ether linkage, an amide linkage or an ester group; R 8 is —CH 2 CH 2 COR 12 where R 12 is an amino acid residue, —NHR 13 or —OR 14 where R 13 is hydrogen, alkyl of 1 to about 20 carbon atoms, or a mono or polysaccharide connected to —NH— through at least one of a saturated or unsaturated lower alkylene group, a saturated or, unsaturated heterocylic or hydrocarbon five or six membered ring, an ether linkage, an amide linkage or an ester group and R 14 is hydrogen, or alkyl of 1 to about 20 carbon atoms, where lower alkyl includes alkyl and alkylene groups of 1 to 5 carbon atoms and alkyl includes linear, branched and cyclic unsubstituted alkyl and linear, branched and cyclic alkyl and alkylene groups substituted with hydroxy, carboxy, alkyl, vinyl, amino, amido, keto, heterocyclic, mono and polysaccharide and amino acid groups; provided that the compound contains at least one mono or polysaccharide group that will combine with galectin-1 and M is a chelated metal or is two hydrogens bound to the unsaturated nitrogens in the a and c rings.