Patent ID: 6992102

Claim:
A compound of the formula Ia wherein R 1 is selected from the group consisting of hydrogen (H), cyano (—CN), nitro (—NO 2 ), halo, OR 4 , CO 2 R 5 , CONHR 5 , COR 5 , S(O) m R 5 , SO 2 NR 5 R 5 ′, NHCOR 5 and NHSO 2 R 5 ; R 2 is selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, arylalkyl or substituted arylalkyl, CO 2 R 5 , CONR 5 R 5 ′ and CH 2 OR 5 ; R 3 is selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, halo, cyano(—CN), NHCOR 5 , NHCO 2 R 5 , NHCONR 5 R 5 ′, NHSO 2 R 5 and OR 4 ; R 4 in each functional group is independently selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, CHF 2 , CF 3 and COR 5 ; R 5 and R 5 ′ in each functional group are each independently selected from the group consisting of hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, and —CN; W is selected from the group consisting of (CR 6 R 6 ′) m , CHOH(CR 6 R 6 ′) m , CO(CR 6 R 6 ′) m and C═NOR 4 (CR 6 R 6 ′) m ; R 6 and R 6 ′ are each independently selected from the group consisting of hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, halo, cyano (—CN), NHCOR 5 , NHCO 2 R 5 , NHCONR 5 R 5 ′, NHSO 2 R 5 and OR 4 ; X is selected from the group consisting of methylene (—CH 2 —); Y is selected from the group consisting of oxygen(O), sulfur(S) and hydrogen (H 2 ); Z is selected from the group consisting of oxygen(O), sulfur(S), NH and NR 5 ; A and B are each independently selected from the group consisting of hydrogen (H), halo, cyano(—CN), nitro(—NO 2 ), alkyl or substituted alkyl and OR 4 ; and m is an integer from 0 to 2; or prodrug esters, pharmaceutically acceptable salts and stereoisomers thereof.