Patent ID: 8895729

Claim:
A process for preparing (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one I, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, comprising: (a) reacting a salt of (S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one 6 and 2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde IV with a reducing agent to give (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one II and (b) reacting II, a palladium catalyst, and 2-aminopyrimidin-5-ylboronic acid III having the structure: to give I.