Patent ID: 7189718

Claim:
A compound according to formula I wherein; X 1 is selected from the group consisting of R 5 O, R 5 S(O) n , R 5 CH 2 , R 5 CH 2 O, R 5 CH 2 S(O) n , R 5 OCH 2 , R 5 S(O) n CH 2 and NR 5 R 6 ; R 1 and R 2 are (i) each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 sulfonyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, nitro and cyano; or, (ii) taken together are —CH═CH—CH═CH—, or (iii) taken together along with the carbons to which they are attached form a five- or six-membered heteroaromatic or heterocyclic ring with a one or two heteroatoms independently selected from the group consisting of O, S and NH; R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkylthio, C 1-6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, nitro and cyano; R 4 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkoxy, C 1-6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, nitro and cyano; R 5 is selected from the group consisting of alkyl, haloalkyl, cycloalkyl, phenyl, naphthyl, pyridinyl, pyridine N-oxide, pyridine N-oxide, indole, indole N-oxide, quinoline, quinoline N-oxide, pyrimidinyl, pyrazinyl and pyrrolyl; wherein, said alkyl and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, and dialkylamino; and, said phenyl, said naphthyl, said pyridinyl, said pyridine N-oxide, said indole, said indole N-oxide, said quinoline, said quinoline N-oxide, said pyrimidinyl, said pyrazinyl and said pyrrolyl groups are optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 alkenyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 sulfonyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, hydroxy, halogen, amino, C 1-6 alkylamino, C 1-6 dialkylamino, aminoacyl, acyl, C 1-6 alkoxycarbonyl, carbamoyl, C 1-6 N-alkylcarbamoyl, C 1-6 N,N-dialkylcarbamoyl, nitro and cyano; R 6 is hydrogen, C 1-6 alkyl, or acyl; R 7 and R 8 taken independently are selected from the group consisting of hydrogen, amino, C 1-6 alkylamino, C 1-6 dialkylamino, amino-C 1-3 alkyl, C 1-3 alkylamino-C 1-3 alkyl, C 1-3 dialkylamino-C 1-3 alkyl or C 1-6 alkyl optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, alkoxy, thiol, alkylthio, C 1-6 alkylsulfinyl, C 1-6 sulfonyl and halogen, N-morpholinyl; n is an integer from 0 to 2; or an acid addition salts thereof.