Patent ID: 8273767

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: Y and Y′ are each independently CH or CF; X, X′, Z and Z′ are each independently C; Z is N; one of R 1 and R 2 is selected from the group consisting of halogen, cyano, and L 2 R 6 ; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halogen, cyano, and thioalkoxy; R 3 is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, cyano, and thioalkoxy; R 3a is absent; R 3b is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, hydroxy, cyano, and thioalkoxy; R 4 and R 5 are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, and (NR A R B )alkyl, or R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the formula: R 6 is selected from the group consisting of aryl, heteroaryl, heterocycle, and cycloalkyl, wherein each R 6 is optionally substituted with 1, 2 or 3 substituents selected from the group consisting alkyl, cyano, halo, —NR A R B , alkoxy, alkoxyimino, hydroxyalkyl, alkylcarbonyl, alkoxycarbonyl, (NR A R B )carbonyl, cycloalkylcarbonyl, alkylsulfonyl, haloalkyl, and thioalkoxy; R 7 , R 8 , R 9 , and R 10 at each occurrence are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl; or one of the pair R 7 and R 8 or the pair R 9 and R 10 is taken together to form a C 3 -C 6 ring, wherein 0, 1, or 2 heteroatoms selected from O, N, or S replace a carbon atom in the ring; R 11 , R 12 , R 13 , and R 14 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro; Q is selected from the group consisting of a bond, O, S, and NR 15 ; L is —[C(R 16 )(R 17 )] n — or —[C(R 16 )(R 17 )] p O—; L 2 is selected from the group consisting of a bond, —O—, —C(═O)—, —S—, —[C(R 18 )(R 19 )] q —, —O—[C(R 18 )(R 19 )] q —, —NH— and —N(alkyl)-; R 15 is selected from the group consisting of hydrogen, alkyl, acyl, amido, and formyl; R 16 and R 17 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro; R 18 and R 19 at each occurrence are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, and fluoro; R x and R y at each occurrence are independently selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, alkylamino, dialkylamino, and fluoro, or one of R x or R y represents a covalent bond when taken together with R x or R y on an adjacent carbon atom such that a double bond is represented between the adjacent carbon atoms; m is an integer from 1 to 5; n is an integer from 1 to 6; p is an integer from 2 to 6; and q is an integer from 1 to 4.