Patent ID: 7265222

Claim:
A process of making compounds of the formula (I): wherein: R 1 is C1-10 alkyl branched or unbranched or C3-10 cycloalkyl each optionally partially or full halogenated; R 2 C1-10 alkyl branched or unbranched, C1-10 alkoxy branched or unbranched, C3-10 cycloalkyl each optionally partially or full halogenated and optionally substituted by aryl or R 2 is aryl; R 3 is attached at the 3- or 4-position on the phenyl ring and is hydrogen, C1-10 alkyl, carbocycle, heterocycle, heteroaryl or R 4 —S(O) 2 —NH— wherein R 4 is chosen from C 1-5 alkyl or carbocycle; R 4 is chosen from C1-5 alkyl or C1-5 alkoxy; for N(Ra) 2 , R a is independently chosen from hydrogen, C1-5 alkyl, aryl, arylC1-3 alkyl, C3-7cycloalkyl, C3-7cycloalkyl C1-3 alkyl, C1-5alkoxyC1-5alkyl and heterocyclyl C1-3 alkyl wherein the heterocycyl is chosen from tetrahydrofuran, pyrrolidinyl and morpholinyl, each R a where possible is optionally substituted by one to two C1-5 alkyl, C1-5 alkoxy or amino di-substituted by C1-5 alkyl; said process comprising a) reacting an aryl amine (II) with a carbamate of the formula (III) in the presence of an aprotic solvent and an aprotic base at a temperature between 0° C. and 100° C. for a time of 1-24 hrs to produce the intermediate compound of the formula (IV): b) reacting intermediate compound of the formula (IV) with a compound of the formula (V) in the presence of polar solvent and an aprotic base at a temperature between 0° C. and 100° C. for a time of 1-24 hrs to produce the intermediate compound of the formula (VI): where in the formula (V), Y 1 is halogen chosen from Cl, Br, I and F and Y 2 is halogen chosen from Cl and F; c) reacting formula (VI) with a HN(Ra) 2 compound wherein Ra is as described above, in the presence of polar aprotic solvent and an aprotic base at a temperature between 0° C. and 100° C. for a time of 1-24 hrs to produce the compound of the formula (I), and subsequently isolating the product compound: