Patent ID: 8426187

Claim:
A bacteriophage population, wherein members of the population comprise: a) at least one coat protein fused to an antibody-binding domain that has the ability to bind to an Fc domain of an antibody, wherein the antibody-binding domain is displayed on the surface of the bacteriophage particle; b) a nucleic acid sequence encoding an antibody having at least an Fc domain and a variable domain wherein the nucleic acid sequence is packaged in the bacteriophage; and c) an antibody encoded by the nucleic acid sequence, wherein the antibody is not fused to a coat protein but is bound to the surface of the bacteriophage by virtue of the Fc domain of the antibody being bound to the antibody-binding domain; and wherein the population of bacteriophages collectively comprises a plurality of nucleic acid sequences encoding a plurality of distinct antibodies.