Patent ID: 8900575

Claim:
An oral composition for degrading oxalate in the stomach comprising a coated particle comprising: a particle comprising an oxalate-degrading enzyme embedded in a first polymeric material that is permeable to oxalate in a pH range of from about 1 to about 5, wherein the first polymeric material is cross-linked to itself and/or to the enzyme, and a coating on the particle, wherein the coating comprises a second polymeric material that is permeable to oxalate in a pH range of from about 1 to about 5, wherein the second polymeric material is cross-linked to itself, to the first polymeric material, and/or to the embedded oxalate-degrading enzyme, wherein reducible bonds between a cross-linking agent and the embedded oxalate-degrading enzyme, the first polymeric material, and/or the second polymeric material have been reduced by a reducing agent.