Patent ID: 7037666

Claim:
A method for the identification of an inhibitor of the interaction between latency associated peptide of transforming growth factor-β1 (LAP-β1) and the integrin α v β 3 , which method comprises: (a) providing, as a first component, LAP-β1 consisting of amino acids 30–278 of SEQ ID NO:1 in the form of a monomer or a homodimer; (b) providing, as a second component, integtin α v β 3 ; (c) contacting the two components with a test product under conditions that, in the absence of the test product, would permit the two components to interact, where the conditions include the presence of cations; and (d) determining whether the test product is capable of inhibiting the interaction between the first and second components, thereby determining whether the test product is an inhibitor of the interaction between (LAP-β1) and integrin α v β 3 .