Patent ID: 7998938

Claim:
A method for inhibiting the proliferation of multiple myeloma cancer cells, the method comprising (a) exposing the cells to the proteasome inhibitor bortezomib, and (b) either proceeding, following, or concomitantly with step (a), exposing the cells to a telomerase inhibitor, wherein the telomerase inhibitor includes an oligonucleotide which is characterized by: (i) N3′→P5′ thiophosphoramidate internucleoside linkages; (ii) having the sequence identified as SEQ ID NO: 12; and (iii) a palmitoyl (C16) moiety linked to the 5′ terminus of the oligonucleotide via a glycerol or aminoglycerol linker; wherein said method provides a supraadditive inhibiting effect relative to the inhibiting effects of the individual agents.