Patent ID: 7572906

Claim:
A conditionally replicating human immunodeficiency viral (HIV) vector comprising: (a) a nucleic acid comprising a human immunodeficiency virus 1 (HIV-1) genome sequence; (b) an HIV-1 5′ long terminal repeat (LTR) and an HIV-1 3′ LTR; (c) a heterologous nucleic acid operably linked to the 5′ LTR, wherein the heterologous nucleic acid comprises an antisense sequence complementary to an HIV-1 env sequence; (d) a lentiviral rev responsive element (rre) sequence; and (e) a “Ψ” or “psi” packaging signal; wherein the conditionally replicating HIV vector lacks all full-length protein-encoding sequences encoding any HIV functional protein, and the HIV-1 antisense env sequence inhibits replication or encapsidation of a replication-competent HIV genome.