Patent ID: 8440806

Claim:
A polynucleotide encoding a V domain of an antibody, wherein the antibody is a humanized hB-F5antibody, wherein said hB-F5 antibody comprises V domains comprising: H chain V domain comprising the sequence: (SEQ ID NO: 1) EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGV ISVKSENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSA SYYRYDVGAWFAYWGQGTLVTVSS; and L chain V domain comprising the sequence: (SEQ ID NO: 2) DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSYIYWYQQKPGQPPKL LIYLASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPW TFGQGTKVEIK, wherein said hB-F5 antibody is able to activate a subset of CD4 + T cells comprising CD4 + CD25 + regulatory T cells.