Patent ID: 7101994

Claim:
A process for preparing a compound of formula VII: wherein: R is —NR 8 R 9 where R 8 and R 9 are each independently selected from the group consisting of H, C 1-6 alkyl, cyanoC 1-6 alkyl, hydroxyC 1-6 alkyl, haloC 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkylC 3-7 cycloalkyl, C 2-6 alkenyl, C 3-7 cycloalkylC 1-6 alkyl, C 2-6 alkynyl, aryl, arylC 1-6 alkyl, and COC 1-6 alkyl; and each R 10 is independently selected from the group consisting of hydroxy and protected hydroxy group; or a pharmaceutically acceptable derivative or prodrug thereof; said process comprising the steps of: (a) cyclizing 4,5-dichloro-o-phenylenediamine with carbonyl di-imidazole to yield a compound of formula II: (b) reacting the compound of formula II with PO(X) 3 wherein X is halo, to prepare a compound of formula I: (c) reacting the compound of formula I with a furanosyl of formula III: to prepare a compound of formula V: (d) reacting the compound of formula V with an amine of formula H—NR 8 R 9 ; to prepare a compound of formula VII or a pharmaceutically acceptable derivative or prodrug thereof.