Patent ID: 8481743

Claim:
A compound of Formula I: wherein A is cycloalkyl or phenyl; R 1 is: H or halo; or C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —O—C 1-6 alkyl, —O—C 2-6 alkenyl, or —O—C 2-6 alkynyl, any of which is optionally substituted —NR 6 R 7 , wherein each of R 6 and R 7 is independently selected from the group consisting of H, or C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; any of which is optionally substituted, R 2 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(═O)C 1-6 alkyl, —C(═O)C 2-6 alkenyl, —C(═O)C 2-6 alkynyl, —S(═O)C 1-6 alkyl, —S(═O)C 2-6 alkenyl, —S(═O)C 2-6 alkynyl, SO 2 C 1-6 alkyl, SO 2 C 2-6 alkenyl, SO 2 C 2-6 alkynyl, —CO 2 C 1-6 alkyl, —CO 2 C 2-6 alkenyl, or —CO 2 C 2-6 alkynyl, any of which is optionally substituted; wherein optionally substituted means that the group is optionally substituted with one or more substituents independently selected from the group consisting of halo, halo(C 1-6 )alkyl, halo 2 (C 1-6 )alkyl, halo 3 (C 1-6 )alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl(C 1-6 )alkyl-, aryl(C 2-6 )alkenyl-, aryl(C 2-6 )alkynyl-, cycloalkyl(C 1-6 )alkyl-, heterocyclo(C 1-6 )alkyl-, hydroxyl(C 1-6 )alkyl-, amino(C 1-6 )alkyl-, carboxy(C 1-6 )alkyl-, alkoxy(C 1-6 )alkyl-, nitro, amino, ureido, cyano, alkylcarbonylamino, hydroxyl, thiol, alkylcarbonyloxy, azido, alkoxy, carboxy, aminocarbonyl, and C 1-6 alkylthiol; and wherein aryl is selected from the group consisting of phenyl, naphthyl, phenanthryl, anthracyl, indenyl, azulenyl, biphenyl, biphenylenyl and fluorenyl; B is (CH 2 ) m wherein m is an integer 0 to 12; R 3 and R 4 are each phenyl; R 5 is H, —C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(═O)NHC 1-6 alkyl, —C(═O)N(C 1-6 alkyl) 2 , alkylaminocarbonyl, dialkylaminocarbonyl or cycloaminocarbonyl; and the pharmaceutically acceptable salts thereof.