Patent ID: 7678904

Claim:
A compound of the formula (I): wherein: X 1 , X 2 and X 3 are O; R 5 , R 6 , R 7 , R 9 , and R 10 are H, and R 4 and R 8 are methyl; and Z is —CH 2 R* wherein R* is an amino acid residue bonded to the Z methylene via a nitrogen or a sulfur atom; or R* is —NR 1 CO 2 —R 2 , —NR 1 C(O)NR 2 , —S—R 1 , —NR 1 R 2 , or —N + R 1 R 2 R 11 Y − wherein R 1 and R 2 are independently selected from H, CN, and optionally substituted straight-chained or branched aliphatic optionally containing 1 or more double or triple bonds; wherein optional substituents are selected from one or more of —NH 2 , —NH(C 1-4 aliphatic), —N(C 1-4 aliphatic) 2 , halogen, —OH, —O—(C 1-4 aliphatic), —NO 2 , —CN, —CO 2 H, —CO 2 (C 1-4 aliphatic), —O(halo C 1-4 aliphatic), or -halo(C 1-4 aliphatic); wherein each C 1-4 aliphatic is optionally substituted; or R 1 and R 2 are independently selected from cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and provided that R 1 and R 2 are not simultaneously H; or where R* is NR 1 R 2 , R 1 and R 2 optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms or a group selected from —CO—, —SO—, and —SO 2 —; R 11 is selected from H or C 1-4 aliphatic; and Y − is selected from the group consisting of fluoride, chloride, bromide, iodide, sulfate, nitrate, bicarbonate, carbonate, acetate, citrate, malonate, tartarate, succinate, benzoate, ascorbate, alpha-ketoglutarate, alpha-glycerophosphate, methylsulfonate, toluenesulfonate, and benzenesulfonate; or a pharmaceutically acceptable salt thereof.