Patent ID: 8802076

Claim:
A method of enhancing an immune response in a subject comprising administering to the subject a nanoparticle comprising: heparin; and chitosan, wherein the heparin and the chitosan nanoparticle encapsulates at least one immunomodulatory agent, in an amount effective to increase an amount of IgA, IgG 1 , IgG 2 , or a combination thereof, wherein the at least one immunomodulatory agent is selected from the group consisting of TNF, IL-12, IL-1α, IL-2, IL-23, IL-18, IL-10, and IFN, wherein the nanoparticle has an absorbance at 400 nm of at least 0.015 at a pH of 6 to 8.5, and wherein the nanoparticle is administered via injection.