Patent ID: 7902344

Claim:
An isolated nucleic acid encoding an isolated antibody or fragment thereof that binds immunologically to Bacillus anthracis protective antigen and comprises the variable light and variable heavy chain of SEQ ID NO:21, with the exception that the variable light and variable heavy chain collectively comprise at least three modifications selected from the group consisting of: I21V, S22G, L33S, Q38R, L46F, Q55L, S56P, T74A, S76N, Q78L, L94P, S7P, K19R, S30N, T57S, K62R, K64E, T68I, and M80L; wherein said I21V, S22G, L33S, Q38R, L46F, Q55L, S56P, T74A, S76N, Q78L and L94P are in the variable light chain and wherein said S7P, K19R, S30N, T57S, K62R, K64E, T68I and M80L are in the variable heavy chain.