Patent ID: 8653056

Claim:
A method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, characterized in that the water-insoluble terpenoid having a free, hydroxy functional group is derivatized on this functional group with a substituent of general formula X a bound to the hydroxy group of the terpenoid, wherein X a is —OC—R—COOH, wherein R is linear or branched C 1 to C 8 alkylene, linear or branched C 3 to C 8 oxaalkylene, linear or branched C 1 to C 8 alkenylene, C 6 cycloalkylene, C 6 cycloalkenylene, C 6 arylene unsubstituted or substituted with halogen, hydroxyl or amino group, wherein the functionalized terpenoid is selected from: wherein R 1 is X a and R 2 is CH 2 CH 3 , CH 3 or H wherein R 1 is X a and R 2 is CH 2 CH 3 , CH 3 or H, wherein R 1 is X a and R 2 is CO 2 CH 3 , and subsequently, the prepared derivative is dissolved in a solution containing water, a gamma-cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the gamma-cyclodextrin.