Patent ID: 8580852

Claim:
A compound selected from the group consisting of: a compound having the structural formula or a pharmaceutically acceptable salt or solvate thereof, wherein: X is CH 2 , O, NH or N(C 1 -C 6 )alkyl; Y and Z form CONH or CH 2 O; R 1 and R 2 are each independently hydrogen, a side chain of a natural amino acid, a linear, branched or cyclic alkyl, a linear, branched or cyclic alkenyl, a linear, branched or cyclic alkynyl, or substituted or unsubstituted aryl; R 3 is hydrogen or (C 1 -C 1 )alkyl; the Activated Carbonyl Group is and a compound having the structural formula or a pharmaceutically acceptable salt or solvate thereof, wherein: X is CH 2 , O, NH or N(C 1 -C 6 )alkyl; Y and Z form CONH or CH 2 O; R 1 is hydrogen, a side chain of a natural amino acid, a linear, branched or cyclic alkyl, a linear, branched or cyclic alkenyl, a linear, branched or cyclic alkynyl, or substituted or unsubstituted aryl; R 3 is hydrogen or (C 1 -C 6 )alkyl, and R 4 is a linear, branched or cyclic alkyl, a linear, branched or cyclic alkenyl, a linear, branched or cyclic alkynyl, or substituted or unsubstituted aryl.