Patent ID: 7432283

Claim:
A compound of Formula I: wherein: R 1 is CHR f R g , C 2-10 alkynyl, C 1-6 haloalkyl, cyano, —(CH 2 ) o S(O) n R i , —(CH 2 ) o S(O) 2 NR j 2 , —NR f SO 2 R i , —C(═Z)R j ; tetrazolyl C 0-3 alkylene IIa or IIb, or C 1-10 alkyl wherein 2 to 3 nonadjacent carbon atoms in the alkyl chain are replaced with —O—, —S— or —NR f with the proviso that when R 1 is NR f SO 2 R i , R i is not optionally substituted phenyl; R 2 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-3 alkyl, C 1-3 alkoxycarbonyl-C 1-3 alkyl; C 1-6 haloalkyl; R 3 is aryl or heteroaryl, each optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, aminosulfonyl, C 1-3 monoalkylaminosulfonyl, C 1-3 dialkylaminosulfonyl, halogen, haloalkyl, cyano, nitro, and —NR a″ R b ″, where R a″ and R b″ are each independently selected from the group consisting of hydrogen, C 1-9 alkyl, and C 1-9 alkylcarbonyl; R f is hydrogen or C 1-10 alkyl; R g is C 2-10 alkenyl; R h is H or C 1-3 alkyl; R i is C 1-6 alkyl, C 2-6 alkenyl, C 1-6 heteroalkyl or phenyl optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, amino, C 1-3 alkylamino, C 1-3 dialkylamino, hydroxyl-C 1-6 alkyl, cyano, acylamino, C 1-3 alkylsulfonyl, C 1-3 alkylsulfonyloxy, and halogen; R j is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, or C 1-6 heteroalkyl; A is CH 2 ; Y is O or H,H; Z is O or NOR f ; m is 1; n is 0 to 2; o is 0 to 6; p is 0 to 3; and racemic or non-racemic mixtures of isomers or pharmaceutically acceptable salts thereof.