Patent ID: 8383360

Claim:
A method of determining a risk of a human offspring for developing an autism spectrum disorder (ASD) comprising detecting in a biological sample from the mother or potential mother of the offspring the presence of maternal antibodies that bind to one or more biomarkers selected from the group consisting of a lactate dehydrogenase (LDH) protein, a guanine deaminase (GDA) protein, a collapsin response mediator protein 1 (CRMP1) protein, a dihydropyrimidinase-like protein 2 (DPYSL2) protein, a stress-induced phosphoprotein 1 (STIP1) protein and a Y Box Binding Protein 1 (YBX1) protein, wherein said biological sample is selected from the group consisting of blood, serum, plasma, and saliva, and wherein the presence of maternal antibodies that bind to the one or more biomarkers indicates an increased risk of the offspring for developing an ASD.