Patent ID: 7192560

Claim:
A method of removing small negatively charged organic molecules from a biological sample mixture, the method comprising: providing a device comprising a plurality of process arrays, wherein each process array of the plurality of process arrays comprises: a plurality of process chambers, each of the process chambers defining a volume for containing a biological sample mixture; and at least one distribution channel connecting the plurality of process chambers of the array; wherein at least one of the process arrays comprises a surface comprising an anion exchange material partially coated with a negatively charged polymer; providing a biological sample mixture comprising small negatively charged organic molecules having a molecular weight of less than about 6,000; wherein the biological sample mixture is selected from the group consisting of a nucleic acid amplification reaction mixture and a nucleic acid labeling reaction mixture; and contacting the biological sample mixture with the surface comprising the anion exchange mnaterial to remove at least a portion of the small negatively charged organic molecules from the biological sample mixture.