Patent ID: 8038993

Claim:
An anti-idiotypic monoclonal antibody directed against an antibody inhibiting human factor VIII (FVIII), said inhibiting antibody being directed against the C2 region of human FVIII, wherein the constant regions of said anti-idiotypic antibody's light chains and heavy chains are constant regions originating from a non-murine species, wherein each of said anti-idiotypic antibody's light chains is encoded by the murine-human chimeric nucleic acid sequence SEQ ID NO: 5 and wherein each of said anti-idiotypic antibody's heavy chains is encoded by the murine-human chimeric nucleic acid sequence SEQ ID NO: 6, and wherein the fucose level/galactose level ratio of the glycan structures of said anti-idiot is antibody, present on the glycosylation site of the Fc region, is less than or equal to 0.6.