Patent ID: 8283355

Claim:
A compound of the general formula I wherein R 1 is alkyl, aryl, heteroaryl, —COR 6 , —COOR 6 , —NR 7 R 8 , —CONR 7 R 8 or —NR 9 COR 10 ; R 2 is aryl or heteroaryl; R 3 represents H or one to three radicals selected from the group consisting of lower alkyl, lower alkoxy, halogen,—NR 7 R 8 , —COOR 6 and —CONR 7 R 8 ; R 4 is H, alkyl, aryl, carbocyclyl, acyl, —OH or heterocyclyl; R 5 is H, halogen, alkyl, aryl, heteroaryl, —OR 6 , —SR 6 , —COR 6 , —COOR 6 , —NR 7 R 8 , —CONR 7 R 8 or —NR 9 COR 10 ; or R 4 and R 5 together with the carbon and nitrogen atoms to which they are attached form a 5-6 membered heterocyclic ring optionally containing a further double bond; R 6 is H, (C 2 -C 20 ) hydrocarbyl or heterocyclyl; R 7 and R 8 are each independently H, hydrocarbyl or heterocyclyl; or R 7 and R 8 together with the nitrogen atom to which they are attached form a 5-6 membered saturated heterocyclic ring, optionally containing 1 or 2 further heteroatoms selected from the group consisting of N, S and O, and wherein said further N atom is optionally substituted by lower alkyl, aralkyl, haloalkyl or hydroxyalkyl; R 9 is H, lower alkyl or phenyl; R 10 is aryl or heteroaryl; wherein said hydrocarbyl, heterocyclyl, aryl and heteroaryl is optionally substituted by one or more radicals selected from the group consisting of lower alkyl, halogen, aryl, heterocyclyl, heteroaryl, nitro, epoxy, epithio, —OR 6 , —SR 6 , —COR 6 , —COOR 6 , —NR 7 R 8 , —CONR 7 R 8 , —NR 7 —COR 6 , —SO 3 R 6 , —SO 2 R 6 , —SO 2 NR 7 R 8 and —NR 7 SO 2 R 6 , wherein R 6 , R 7 and R 8 are as defined above; or an enantiomer or a pharmaceutically acceptable salt thereof.