Patent ID: 8222251

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein A, B, C, and D are independently selected from CH or N, provided that at least one but no more than two of A, B, C, and D is N, Cy 1 is phenyl optionally substituted independently with 1-5 substituents, wherein the substituents are selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, halogen, cyano, hydroxy, oxo, —OR c , —NR a R b , —NR a C(═O)R b , —C(═O)OR c , —R c OC(═O)NR a R b , —R c OH, —C(═O)NR a R b , —OC(═O)NR a R b , —OC(═O)R c —NR a C(═O)R c , —R b N(R a )C(═O)R c , —R b N(R a )C(═O)OR c , —NR a S(═O) m R c , —S(═O) m NR a R b , and —S(═O) m R c ; R 1 , R 2 , R 3 , and R 4 are each independently selected from H, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 haloalkyl, oxo, —C(═O)OR a , —R c OH, —OR c , —NR a R b , —NR a C(═O)R b , —C(═O)OR c , —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and —S(═O) m R c , provided that at least one of R 1 , R 2 , R 3 , and R 4 is not H; R a , R b , and R c are each independently selected from H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, heterocyclyl, aryl, and heteroaryl; m is 1 or 2; L is —C(═O)— or —S(═O) m —; R 5 is —NR a R b or Cy 2 ; Cy 2 is a partially or fully saturated or unsaturated 6-membered monocyclic ring formed of carbon atoms optionally including 1-3 heteroatoms, wherein the ring is optionally substituted independently with 1-5 substituents, wherein the substituents are independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, halogen, cyano, hydroxy, oxo, —C(═O)OR c , —R c OH, —OR c , —NR a R b , —NR a C(═O)R b , —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and —S(═O) m R c .