Patent ID: 8008315

Claim:
A compound of formula (I): wherein: X is O or NH; Y is N; R 1 is (1) aryl selected from the group consisting of phenyl and napthyl, or (2) heterocyclyl selected from the group consisting of piperazinyl, piperidinyl, pyrrolidinyl, pyrazinyl, dihydropyrazinyl, pyrazolyl, dihydropyrazolyl, pyridazinyl, pyridyl, dihydropyridinyl, pyrimidinyl, dihydropyrimidinyl, pyrrolyl, dihydropyrrolyl, tetrazolyl, dihydrotetrazolyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, imidazolyl, dihydroimidazolyl, triazinyl, pyranyl, tetrahydropyranyl, thiazolyl, thienyl, dihydrothienyl, thiophenyl, triazolyl, dihydrotriazolyl, morpholinyl, thiomorpholinyl, dihydrothiadiazolyl, tetrahydrothienyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl, wherein said aryl or heterocyclyl is unsubstituted or substituted with one or more (a) halo, (b) —C 1-6 alkyl, (c) —C 2-6 alkenyl, (d) —C 2-6 alkynyl, (e) —OH, (f) —CN, or (g) —O—C 1-6 alkyl; R 2 is selected from the group consisting of: (1) R 4 —S(O) 2 N(R 7 )—, wherein R 4 is C 1-6 alkyl, wherein said alkyl is unsubstituted or substituted with one or more (a) halo, (b) —C 2-6 alkynyl, (c) —OH, (d) —CN, or (e) —O—C 1-6 alkyl; and R 7 is selected from the group consisting of (a) hydrogen, and (b) —C 1-6 alkyl, wherein said alkyl is unsubstituted or substituted with one or more (i) halo, (ii) —C 1-6 alkyl, (iii) —OH, (iv) —CN, or (v) —O—C 1-6 alkyl; R 3 is selected from the group consisting of: wherein R 5 is C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; R 6a , R 6b , and R 6c are independently selected from the group consisting of: (1) hydrogen, (2) halo, (3) —C 1-6 alkyl, (4) —C 2-6 alkenyl, (5) —C 2-6 alkynyl, (6) —OH, (7) —CN, and (8) —O—C 1-6 alkyl; R 9 and R 10 are independently selected from the group consisting of: (1) hydrogen, and (2) C 1-6 alkyl, (3) —C 2-6 alkenyl, and (4) —C 2-6 alkynyl, or R 9 and R 10 are joined together with the nitrogen atom to which they are attached to form a pyrrolidine ring, which is optionally substituted with (a) C 1-6 alkyl, (b) —C 2-6 alkenyl, (c) —C 2-6 alkynyl, (d) (CH 2 ) n -phenyl, and (e) (CH 2 ) n -furanyl; wherein said alkyl, phenyl and furanyl are unsubstituted or substituted with one or more i) halo, ii) —C 1-6 alkyl, iii) —OH, iv) —CN, or v) —O—C 1-6 alkyl; and R 11 is selected from the group consisting of (1) —CH—, (2) —O—, and (3) —NH—, provided that when R 11 is —CH— the dotted line forms a bond and when R 11 is —O— or —NH— the dotted line is absent; R 12 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; m is 1 or 2; n is 0, 1, 2, 3 or 4; p is 1, 2, 3 or 4; and pharmaceutically acceptable salts thereof.