Patent ID: 6869618

Claim:
A manufacturing process for the in-situ conversion and incorporation of a salt or free base of an active pharmaceutical ingredient selected from the group consisting of an antihistamine, a decongestant, an antitussive and an anticholinergic for incorporation into a therapeutic liquid or semi-solid dosage form, the process comprising the steps of: (a) dissolving the salt or free base of the active pharmaceutical ingredient in a pharmaceutically acceptable liquid to form a solution; at (b) separately adding a dispersing agent comprising magnesium aluminum silicate, xanthan gum or mixtures thereof and tannic acid to a pharmaceutically acceptable liquid to form a dispersion; (c) transferring the solution from step (a), to the dispersion in step (b) to form a precipitate of a tannate salt complex of the active pharmaceutical ingredient; and (d) combining the tannate salt complex of the active pharmaceutical ingredient without isolation or purification with a pharmaceutically acceptable excipient to generate a therapeutic dosage form.