Patent ID: 7430475

Claim:
A method for constructing a gene network and a graph of network relationships associated with said gene network, comprising the steps of: (a) providing a quantitative disruptant data library for a set of genes of an organism, said library including expression results based on disruption of each gene in said set of genes, quantifying an average effect and a measure of variability of each disruption on each other of said genes; (b) creating a gene expression matrix from said library, said gene expression matrix represents expression of each of said genes by each of said other genes in the library; (c) constructing said graph of network relationships between said genes in said expression matrix, said constructing said graph carried out by a computerized visualization and simulation method comprising minimizing a BNRC criterion; wherein said step of minimizing a BNRC criterion comprises computing maximum likelihood estimation; and (d) outputting said graph to a user.