Patent ID: 8518976

Claim:
A compound of formula I, wherein: A is —CH 2 —CH 2 —, —CH 2 —CH 2 —CH 2 — or —Y—CH 2 —CH 2 —, wherein all CH 2 groups are optionally substituted by one or more identical or different substituents R 4 , and wherein Y is O, S or NR 11 ; Het is a pyridinediyl group optionally substituted by one or more identical or different substituents R 5 ; X is a direct bond or CH 2 ; R 1 and R 2 , together with the N—CO group to which they are attached, form a 2-oxo-pyrrolidin-1-yl or a 2,5-dioxo-pyrrolidin-1-yl ring optionally substituted by one or more identical or different substituents R 8 ; R 3 is phenyl or naphthalenyl, each of which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkyloxy-(C 1 -C 2 )-alkyl-, OH, (C 1 -C 4 )-alkyloxy, (C 1 -C 2 )-alkylenedioxy, (C 1 -C 4 )-alkylmercapto, NH 2 , (C 1 -C 4 )-alkylamino, di((C 1 -C 4 )-alkyl)amino, ((C 1 -C 4 )-alkyl)-CONH—, di((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyloxy)carbonyl-, COOH, CONH 2 , CN, CF 3 , H 2 NSO 2 — and (C 1 -C 4 )-alkyl-SO 2 —, wherein the substituents (C 1 -C 4 )-alkyloxy and (C 1 -C 2 )-alkylenedioxy are independently optionally substituted by one or more fluorine atoms; R 4 is (C 1 -C 4 )-alkyl or fluorine; R 5 is halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkyloxy-(C 1 -C 2 )-alkyl-, OH, (C 1 -C 4 )-alkyloxy, (C 1 -C 4 )-alkylmercapto, NH 2 , (C 1 -C 4 )-alkylamino, di((C 1 -C 4 )-alkyl)amino, ((C 1 -C 4 )-alkyl)-CONH—, di((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyloxy)carbonyl-, COOH, CONH 2 , CN, CF 3 or (C 1 -C 4 )-alkyl-SO 2 —, wherein the substituent (C 1 -C 4 )-alkyloxy is optionally substituted by one or more fluorine atoms; R 8 is halogen, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl-C 1 H 2n —, phenyl-C 1 H 2n —, (C 1 -C 4 )-alkyloxy-(C 1 -C 2 )-alkyl-, OH, oxo, (C 1 -C 4 )-alkyloxy, (C 1 -C 2 )-alkylenedioxy, (C 1 -C 4 )-alkylmercapto, NH 2 , (C 1 -C 4 )-alkylamino, di((C 1 -C 4 )-alkyl)amino, ((C 1 -C 4 )-alkyl)-CONH—, di((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyl)aminocarbonyl-, ((C 1 -C 4 )-alkyloxy)carbonyl-, COOH, CONH 2 , CN, CF 3 , H 2 NSO 2 — or (C 1 -C 4 )-alkyl-SO 2 —, wherein the substituents (C 1 -C 4 )-alkyloxy and (C 1 -C 2 )-alkylenedioxy are independently optionally substituted by one or more fluorine atoms, and all phenyl groups are independently of each other optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, CF 3 and (C 1 -C 4 )-alkyloxy; R 11 is hydrogen, (C 1 -C 4 )-alkyl or ((C 1 -C 4 )-alkyl)-CO—; and n is 0, 1 or 2; or its stereoisomeric form or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof; provided that the compound of formula I is not: 2-amino-6-(2-(2-oxopyrrolidin-1-yl)ethylamino)-4-phenylpyridine-3,5-dicarbonitrile.