Patent ID: 7589180

Claim:
An antibody capable of binding EGFR on tumors containing amplifications of the EGFR gene, wherein cells of the tumor contain multiple copies of the EGFR gene, and on tumors that express the truncated version of the EGFR receptor de2-7, wherein said antibody does not bind to the de2-7 EGFR junctional peptide consisting of the amino acid sequence of SEQ ID NO: 13, wherein said antibody comprises a heavy chain and light chain and the heavy chain variable region sequence comprises polypeptide binding domain CDRs corresponding to amino acids 26-36, 50-65, and 97-105 of SEQ ID NO: 11 and the light chain variable region sequence comprises polypeptide binding domain CDRs corresponding to residues 24-34, 50-56, and 89-97 of SEQ ID NO: 12.