Patent ID: 8182812

Claim:
A method of inhibiting proliferation of an activated T cell expressing CD25, wherein the T cell is associated with an autoimmune disorder, transplant rejection, or graft-versus-host disease, comprising administering a monoclonal antibody that binds human CD25, such that proliferation of the cell is inhibited, wherein the antibody is selected from the group consisting of: (a) an antibody comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 35, 36, and 37, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 38, 39, and 40, respectively; (b) an antibody comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 17, 18 and 19, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 20, 21, and 22, respectively; (c) an antibody comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 23, 24, and 25, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 26, 27, and 28, respectively; (d) an antibody comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 29, 30, and 31, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs: 32, 33, and 34, respectively; (e) an antibody having heavy and light chain variable regions comprising the amino acid sequences as set forth in SEQ ID NO: 6 and SEQ ID NO: 8, respectively; (f) an antibody having heavy and light chain variable regions comprising the amino acid sequences as set forth in SEQ ID NO: 14 and SEQ ID NO: 16, respectively; (g) an antibody having a heavy chain and a light chain variable regions comprising the amino acid sequences as set forth in SEQ ID NO: 2 and SEQ ID NO: 4, respectively; and (h) an antibody having a heavy chain and a light chain variable regions comprising the amino acid sequences as set forth in SEQ ID NO: 10 and SEQ ID NO: 12, respectively.