Patent ID: 7811785

Claim:
An isolated nucleic acid molecule encoding an antibody, or an Fab fragment thereof, wherein the antibody, or Fab fragment thereof, binds to human VEGF and comprises a heavy chain variable domain and a light chain variable domain wherein the heavy chain variable domain comprises a CDR H1, CDR H2, and CDR H3, wherein: (a) CDR H1 comprises the contiguous amino acid sequence DYWIH (SEQ ID NO: 261); (b) CDR H2 comprises the contiguous amino acid sequence GITPAGGYTYYADSVKG (SEQ ID NO: 474); and (c) CDR H3 comprises the contiguous amino acid sequence FVFFLPYAMDY (SEQ ID NO: 475); and wherein the light chain variable domain comprises a CDR L1, CDR L2, and CDRL3, wherein: (d) CDR L1 comprises the contiguous amino acid sequence RASQDVSTAVA (SEQ ID NO: 48); (e) CDR L2 comprises the contiguous amino acid sequence SASFLYS (SEQ ID NO: 49; and (f) CDR L3 comprises the contiguous amino acid sequence QQSYTTPPT (SEQ ID NO: 363).