Patent ID: 7387771

Claim:
A process for producing an injectable medicament preparation comprising: dissolving at least one therapeutically effective substance in an injectable carrier liquid, wherein the therapeutically effective substance comprises an active compound selected from the group consisting of cytostatic agent, a cytokine, an immunosuppressive agent, a virostatic agent, an antirheumatic agent, an analgesic, an antiinflammatory agent, an antibiotic, an antimycotic agent, a signal transduction inhibitor, an angiogenesis inhibitor or a protease inhibitor and at least one covalently protein-binding molecular residue selected from the group consisting of maleimide, haloacetamide, haloacetate, pyridylthio, N-hydroxysuccinimide ester, isothiocyanate, disulphide, vinylcarbonyl, aziridine and acetylene, which are linked by a spacer comprising an organic molecular residue, which contains at least one aliphatic carbon chain, or an aliphatic carbon ring having 1-12 carbon atoms, some of which can be replaced with oxygen, or at least one aromatic moiety, in which the spacer, or the bond between the active compound and the spacer, can be cleaved hydrolytically or enzymatically in the body of a subject in a pH-dependent manner.