Patent ID: 7786099

Claim:
A tetracycline compound of the formula (I) wherein R 1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl, amido, alkylamino, amino, arylamino, alkylcarbonyl, arylcarbonyl, alkylaminocarbonyl, alkoxy, alkoxycarbonyl, alkylcarbonyloxy, alkyloxycarbonyloxy, arylcarbonyloxy, aryloxy, thiol, alkylthio, arylthio, heterocyclic, hydroxyl or halogen; R 2′ , R 2″ , R 4a and R 4b are each independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic or a prodrug moiety; R 10 and R 11 are each independently hydrogen, alkyl, aryl, benzyl, arylalkyl or a pro-drug moiety; R 3′ is hydroxyl, alkoxy, arylalkyloxy, hydrogen or a pro-drug moiety; R 4 is NR 4a R 4b , alkyl, alkenyl, alkynyl, hydroxyl or halogen; R 5 and R 5′ are each independently hydroxyl, hydrogen, thiol, alkanoyl, aroyl, alkaroyl, aryl, heteroaromatic, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, alkyl carbonyloxy or aryl carbonyloxy; R 6 and R 6′ are each hydrogen; R 7 is hydroxyl, substituted alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyl, amino, arylalkenyl, arylalkynyl, acyl, aminoalkyl, heterocyclic, thionitroso or —(CH 2 ) 0-3 NR 7c C(═W′)WR 7a ; R 8 is hydrogen, hydroxyl, halogen, thiol, nitro, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, amino, arylalkenyl, arylalkynyl, acyl, aminoalkyl, heterocyclic, thionitroso or —(CH 2 ) 0-3 NR 8c C(═E′)ER 8a ; R 9 is hydrogen, hydroxyl, halogen, thiol, nitro, substituted alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyl, amino, arylalkenyl, arylalkynyl, acyl, aminoalkyl, heterocyclic, thionitroso or —(CH 2 ) 0-3 NR 9c C(═Z′)ZR 9a ; R 7a , R 7b , R 7c , R 7d , R 7e , R 7f , R 8a , R 8b , R 8c , R 8d , R 8e , R 8f , R 9a , R 9b , R 9c , R 9d , R 9e and R 9f are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic or a prodrug moiety; E is CR 8d R 8e , S, NR 8b or O; E′ is O, NR 8f or S; W is CR 7d R 7e , S, NR 7b or O; W′ is O, NR 7f or S; X is CR 6′ R 6 ; Z is CR 9d R 9e , S, NR 9b or O; and Z′ is O, S or NR 9f , and pharmaceutically acceptable salts, esters and enantiomers thereof.