Patent ID: 7354928

Claim:
A pharmaceutical composition for modulation of apoptosis in a subject, comprising one or more anticancer agents and a therapeutically effective amount of a compound of formula: wherein, Z is O or S; X is selected from the group consisting of hydrogen and OR, wherein R is selected from the group consisting of hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 ) -alkenyl, (C 3 -C 8 )-cycloalkyl, phenyl and trifluoromethyl; A 1 and A 2 are each independently 1 to 3 substituents selected from the group consisting of hydrogen, hydroxy, branched or straight chain (C 1 -C 6 )-alkyl, branched or straight chain (C 2 -C 6 )-alkenyl, (C 3 -C 8 )-cycloalkyl, phenyl, aryl, (C 1 -C 6 )-alkoxy, CZ 3 (wherein Z is selected from the group consisting of F, Cl, Br and I), NH 2 , NH((C 1 -C 6 )-alkyl), N((C 1 -C 6 )-alkyl) 2 , NO 2 , CN, COOH, COO(C 1 -C 6 )-alkyl, CONH 2 , CONH(C 1 -C 6 )-alkyl, CON((C 1 -C 6 )alkyl) 2 , Oâ€”(C 1 -C 6 )-alkyl (where one, more than one or all hydrogen(s) in the alkyl radicals may be replaced by fluorine, or one hydrogen may be replaced by OH, OC(O)CH 3 , OC(O)H, Oâ€”CH 2 â€”Ph, NH 2 , NH((C 1 -C 6 )-alkyl), N((C 1 -C 6 )-alkyl) 2 , NHâ€”COâ€”CH 3 , or N(COOCH 2 Ph) 2 ), SO 2 â€”NH 2 , SO 2 NH(C 1 -C 6 )-alkyl, SO 2 N((C 1 -C 6 )-alkyl) 2 , Sâ€”(C 1 -C 6 )alkyl, Sâ€”(CH 2 ) n -phenyl, SOâ€”(C 1 -C 6 )-alkyl, SOâ€”(CH 2 ) n -phenyl, SO 2 -(C 1 -C 6 )-alkyl, SO 2 -(CH 2 ) n -phenyl (where n is 0-6 and the phenyl radical may be substituted up to two times by F, Cl, Br, I, OH, CF 3 , NO 2 , CN, OCF 3 , Oâ€”(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, NH 2 , NH((C 1 -C 6 )-alkyl), N((C 1 -C 6 )-alkyl) 2 ), NH(C 1 -C 7 )-acyl, phenyl, biphenylyl, Oâ€”(CH 2 ) n -phenyl (where n is 0-6), 1- or 2-naphthyl, 2-, 3-, or 4-pyridyl, 2- or 3-furanyl, 2- or 3-thienyl (wherein the phenyl, biphenylyl, naphthyl, pyridyl, furanyl, and thienyl rings may be optionally substituted up to 3 times by F, Cl, Br, I, OH, CF 3 , NO 2 , CN, OCF 3 , Oâ€”(C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl, NH 2 , NH(C 1 -C 6 )-alkyl, N((C 1 -C 6 )-alkyl) 2 , SO 2 â€”CH 3 , COOH, COOâ€”(C 1 -C 6 )-alkyl or CONH 2 ), 1,2,3-triazol-5-yl (wherein the triazol ring may be optionally substituted in position 1, 2 or 3 by methyl or benzyl) or tetrazol-5-yl (wherein the tetrazol ring may be optionally substituted in position 1 or 2 by methyl or benzyl); and pharmaceutically acceptable salts and derivatives thereof; and a pharmaceutically acceptable carrier; wherein said compound is present in an amount effective to modulate apoptosis in a subject.