Patent ID: 8222421

Claim:
At least one chemical entity chosen from compounds of Formula 3 and pharmaceutically acceptable salts thereof, wherein U, V, and W are CH; R represents 0 to 2 substituents independently chosen from hydroxy, nitro, cyano, optionally substituted amino, aminocarbonyl, halo, carboxy, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkoxy, sulfanyl, sulfinyl, sulfonyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocycloalkyl; R 1 is optionally substituted pyridin-4-yl; Z 1 is —CR 5 R 6 — wherein each R 5 and R 6 is independently chosen from hydrogen, optionally substituted C 1 -C 6 alkyl, and halo; and m is chosen from 0, 1, and 2; R 2 is optionally substituted aryl; and R 3 and R 4 are each independently chosen from hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted aryl, and optionally substituted heteroaryl.