Patent ID: 7691887

Claim:
A method for the treatment of a Hedgehog-expressing cancer selected from the group consisting of basal cell carcinoma, prostate cancer, pancreatic cancer, small cell lung cancer, gastrointestinal cancer, and medulloblastoma, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: 2 of X, Y and Z represent nitrogen atoms, and the other represents an oxygen atom; R 1 and R 2 are taken together with the atom to which they are attached and represent a cyclobutyl ring, optionally substituted with 1-2 fluorine atoms, and R 3 represents hydrogen or a fluorine atom; or R 1 represents methyl, R 2 represents methyl or a fluorine atom and R 3 represents a fluorine atom.