Patent ID: 7605172

Claim:
A compound of formula 1: or pharmaceutically acceptable salt or ester form thereof; wherein: Ar is phenyl; R 1 is hydrogen, C 1 -C 12 alkyl, —(CH 2 ) p —CO—(C 1 -C 6 )alkyl, C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, halogen, or C 1 -C 3 perfluoroalkoxy; R 2 and R 3 are independently hydrogen, C 1 -C 12 alkyl, halogen, C 1 -C 6 alkoxy, nitro, carboxy(C 1 -C 6 alkyl), carbamide, carbamate; R 4 is —CH(R 6 )(CH 2 ) n R 5 , —C(CH 3 ) 2 R 6 , —CH(R 5 )(CH 2 ) n R 6 , —CH(R 5 )C 6 H 4 R 6 , —CH(R 5 )C 6 H 3 (CO 2 H) 2 , CH(R 5 )C 6 H 2 (CO 2 H) 3 , R 5 is hydrogen, C 1 -C 6 alkyl, C 6 -C 12 aryl, aralkyl, C 3 -C 8 cycloalkyl, or —(CH 2 ) n (R 7 ); R 6 is CO 2 H, tetrazole, or PO 3 H; R 7 is n is from 0 to 6; p is from 0 to 3; b is from 0 to 6; and a is from 0 to 6.