Patent ID: 6949533

Claim:
A compound having the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: each of C1, C2, C3, C4, C11, C12, C15 and C16 is independently substituted with (a) one of: ═O, ═C(R 4 )(R 4 ), —C(R 4 )(R 4 )(C(R 4 )(R 4 )) n — and —(O(C(R 4 )(R 4 )) n O)— wherein n ranges from 1 to about 6; or (b) two of the following, which are independently selected: —X, —R 4 and —OR 1 ; each of C5, C8, C9, C10, C13 and C14 is independently substituted with one of —X, —R 4 or —OR 1 ; the A, B, C and D rings are each fully saturated; each R 1 is H or a protecting group such that —OR 1 is a protected hydroxyl group, where vicinal —OR 1 groups may together form a cyclic structure which protects vicinal hydroxyl groups; R 4 at each occurrence is independently selected from H and C 1-30 organic moiety that may optionally contain at least one heteroatom selected from the group consisting of boron, halogen, nitrogen, oxygen, silicon and sulfur, where two geminal R 4 groups may together form a ring with the carbon atom to which they are both bonded; R 5 is R 4 or —OR 6 ; each R 6 is a protecting group such that —OR 6 is a protected hydroxy group; or each R 6 is a C 1-30 organic moiety that may optionally contain at least one heteroatom selected from the group consisting of boron, halogen, nitrogen, oxygen, silicon and sulfur; or R 5 and R 6 , together with C17 to which they are attached, may form a cyclic 3-6 membered ether or 4-6 membered lactone; X represents fluoride, chloride, bromide and iodide; with the proviso that when C10 is substituted with methyl, then C5 is not directly bonded to an oxygen atom.