Patent ID: 8361964

Claim:
A growth hormone releasing factor (GRF) analog comprising a domain of formula (I) (SEQ ID NO: 1): X1-X2-Asp-Ala-Ile-Phe-Thr-X8-X9-Tyr-X11-X12-X13-Leu-X15-Gln-Leu-X18-X19-Arg-Gln-X22-X23-X24-X25-X26-X27-X28-X29-X30-X31-X32-X33(1) wherein: X1 is Tyr or H is; X2 is Ala, D-Ala, Ser, Leu, α-aminoisobutyric acid (Aib), Val or Gly; X8 is Asn, Asp, Ala, Gln, Ser or Aib; X9 is Ser, Asp or Ala; X11 is Arg or L-Homoarginine (HoArg); X12 is Lys, L-Ornithine (Orn) or HoArg; X13 is Val or Ile; X15 is Gly or Ala; X18 is Lys, L-Ornithine, L-2,4-diaminobutyric acid, L-2,3-diaminopropionic acid, or Ser; X19 is Ala or Leu X22 is Asp or Glu; X23 is Ile or Leu; X24 is Met, Ile, Nle or Leu; X25 is Ser, Asn, Aib or Ala; X26 is Arg, D-Arg, HoArg or Lys; X27 is Ala or is absent; X28 is Ala or is absent; X29 is Arg or is absent; X30 is Ala or is absent; X31 is Ala or is absent; X32 is Arg or is absent; X33 is L-Homoserine (HoSer) or is absent; and wherein if X18 is Ser, X27 to X32 or X27 to X33 are present, or a pharmaceutically acceptable salt thereof.