Patent ID: 7517905

Claim:
Compounds having the structure of Formula I and their pharmaceutically acceptable salts, pharmaceutically acceptable enantiomers, diastereomers, or N-oxides, wherein Ar represents an aryl or a heteroaryl ring having 1-2 hetero atoms selected from the group consisting of oxygen, sulphur or nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), trifluoromethyl, methylenedioxy, cyano, hydroxy, halogen (e.g. F, Cl, Br, I), nitro, lower alkoxy (C 1 -C 4 ), amino or lower alkylamino (C 1 -C 4 ); R 1 represents hydrogen, lower alkyl (C 1 -C 4 ), lower alkenyl (C 1 -C 4 ), lower alkynyl (C 1 -C 4 ), aryl or aralkyl; R 2 represents hydrogen or lower alkyl (C 1 -C 4 ); A represents (CH 2 ) n or CO, wherein n is an integer in the range of 0 to 4; W represents (CH 2 ) p , wherein p represents 1 to 4; X represents O, S, NR or no atom, wherein R represents H or lower alkyl (C 1 -C 4 ); Y represents CHR 5 CO, (CH 2 ) q or no atom, wherein R 5 represents hydrogen or methyl and q represents 1 to 4; and R 3 and R 4 are independently selected from hydrogen, straight chain or branched alkyl (C 1 -C 4 ), cycloallyl, CO 2 C(CH 3 ) 3 , optionally substituted aryl or aralkyl.