Patent ID: 7452550

Claim:
A method for modulating the plasma circulation half-life of vinorelbine in a subject, comprising: (a) providing a liposomal formulation comprising: a liposome having free vinorelbine in solution and precipitated vinorelbine encapsulated therein; and (b) adding a liposome having no vinorelbine encapsulated therein to the liposomal formulation; wherein the liposome having encapsulated vinorelbine and the liposome having no encapsulated vinorelbine comprise sphingomyelin and cholesterol at a ratio in the range of about 75/25 mol %/mol % sphingomyelinl/cholesterol to about 30/50 mol %/mol % sphingomyelinl/cholesterol, wherein the ratio of the vinorelbine to lipid is 0.2-0.3:1 (w/w), and wherein the precipitated vinorelbine in the liposome is at least 50% of the total vinorelbine in the formulation; and administering the liposomal formulation to the subject, thereby modulating the plasma circulation half-life of vinorelbine in the subject.