Patent ID: 8828435

Claim:
A buccal delivery formulation comprising a matrix consisting of: (a) up to 60% by weight of the total matrix of one or more bisphosphonic acids or bisphosphonate salts selected from the group consisting of alendronate, etidronate, pamidronate, tiludronate, risedronate compounds, and mixtures thereof; (b) q.s. of one or more polyethylene glycols or PEG-fatty acid esters having surfactant properties selected from the group consisting of PEG 1450, PEG-10 laurate, PEG-12 laurate, PEG-20 laurate, PEG-32 laurate, PEG-32 dilaurate, PEG-12 oleate, PEG-15 oleate, PEG-20 oleate, PEG-20 dioleate, PEG-32 oleate, PEG-200 oleate, PEG-400 oleate, PEG-15 stearate, PEG-32 distearate, PEG-40 stearate, PEG-100 stearate, PEG-20 dilaurate, PEG-25 glyceryl trioleate, PEG-32 dioleate, PEG-20 glyceryl laurate, PEG-30 glyceryl laurate, PEG-20 20 glyceryl stearate, PEG-20 glyceryl oleate, PEG-30 glyceryl oleate, PEG-30 glyceryl laurate, PEG-40 glyceryl laurate, PEG-40 palm kernel oil, PEG-50 hydrogenated castor oil, PEG-40 castor oil, PEG-35 castor oil, PEG-60 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-60 corn oil, PEG-6 caprate/caprylate glycerides, PEG-8 caprate/caprylate glycerides, polyglyceryl-10 laurate, PEG-30 cholesterol, PEG-25 phyto 25 sterol, PEG-30 soya sterol, PEG-20 trioleate, PEG-40 sorbitan oleate, PEG-80 sorbitan laurate, PEG-1450, polysorbate 20, polysorbate 80, POE-9 lauryl ether, POE-23 lauryl ether, POE-10 oleyl ether, POE-20 oleyl ether, POE-20 stearyl ether, tocopheryl PEG-100 succinate, PEG-24 cholesterol, polyglyceryl-10 oleate, polysorbate, a poloxamer, and mixtures thereof; (c) 0.05-2% by weight of the total matrix of one or more suspending agents selected from the group consisting of tetragonolobus, Acacia glaucophylla, Acacia abyssinica, Acacia nilotica, Acacia gummifera, Acacia Arabica , silica gel, povidone, polyvinyl alcohol-polyethylene glycol graft-copolymer, polyethylene glycol (15)-hydroxystearate, (a mixture of lactose monohydrate, povidone and crosspovidone) and mixtures thereof; (d) 0.05-2% by weight of the total matrix of magnesium stearate; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners selected from the group consisting of sucrose, sucralose, zinc gluconate, ethyl maltitol, glycine, acesulfame-K, aspartame, saccharin, fructose, xylitol, honey, corn syrup, golden syrup, misri, spray dried licorice root, glycerrhizine, dextrose, sodium gluconate, stevia powder, glucono delta-lactone, ethyl vanillin, vanillin, normal and high-intensity sweeteners or syrups or salts thereof and mixtures thereof.