Patent ID: 7365062

Claim:
A compound of Formula (I), wherein R 1 is one to three members independently selected from hydrogen, halogen, amino, substituted amino, hydroxy, alkyloxy, phenyl, substituted phenyl, alkylthio, arylthio, alkyl-sulfoxide, aryl-sulfoxide, alkyl-sulfone, and aryl-sulfone; wherein R′ is -B p -G-E q -W wherein (a) B is selected from (CH 2 ) m , NH and O; (b) G is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl; (c) E is O, S, NH, (CH 2 ) i N(R″)CO or (CH 2 ) i CONR″ wherein R″ is selected from hydrogen, alkyl, and substituted alkyl; (d) W is one to three members independently selected from hydrogen, alkyl, substituted alkyl, amino, substituted amino, alkylthiophenyl, alkyl-sulfoxidephenyl, aryl, substituted aryl heteroaryl and substituted heteroaryl; (e) p is independently 0 or 1; (f) q is independently 0 or 1; (g) m is independently 1, 2, or 3; and (h) i is independently 0, 1, 2, or 3; R 4 is one or two members independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, phenyl, and substituted phenyl; R 5 is selected from hydrogen, alkyl, substituted alkyl, aldehyde, carboxyl, alkoxycarbonyl, substituted alkoxycarbonyl, —(CH 2 ) k NZ 1 Z 2 and —CONZ 1 Z 2 wherein k is an integer from 1-4, and Z 1 and Z 2 are independently selected from hydrogen, alkyl, substituted alkyl, heterocyclyl, substituted heterocyclyl, aminocarbonyl, and substituted aminocarbonyl, or N, Z 1 and Z 2 together form heterocyclyl, substituted heterocyclyl, heteroaryl, or substituted heteroaryl; a represents a single or double bond provided that when R 1 is iodine, bromine, alkylthio, arylthio, alkyl-sulfone, or aryl-sulfone, a is a double bond; A is selected from phenyl or substituted phenyl; X is selected from CH, CH 2 , CHOH, and C═O; and n is 1, 2, or 3; or an optical isomer, enantiomer, diastereomer, racemate thereof, or a pharmaceutically acceptable salt thereof.