Patent ID: 8569535

Claim:
A compound of the formula Ia wherein: A is CH═CH; R 23 is hydrogen, halogen, (C 1 -C 4 )-alkyl, or (C 1 -C 4 )-alkyloxy; R 24 is hydrogen or halogen; X is N(H)C═O; Y is C(R 12 )═C(R 13 ); R 12 is (C 1 -C 6 )-alkyl, (C 3 -C 6 )-alkenyl, (C 4 -C 6 )-cycloalkyloxy, (C 5 -C 6 )-cycloalkyl, (C 5 -C 6 )-cycloalkenyl, (C 3 )-cycloalkyl[(C 2 )-alkyl or (C 2 )-alkenyl], (C 3 )-cycloalkyl(C 1 )-alkyloxy, (C 3 -C 4 )-alkyloxy, (C 3 )-alkenyloxy, (C 1 -C 3 )-alkyl-S—, or (C 3 )-alkylcarbonyl; R 13 is hydrogen, halogen, or (C 1 )-alkyl; R 21 is hydrogen; R 22 is hydrogen, halogen, or (C 1 )-alkyl; and R 51 is COOH; wherein all alkyl groups herein can independently of each other be optionally substituted by one or more fluorine atoms; or a pharmaceutically acceptable ester thereof, a stereoisomeric form thereof, mixture of stereoisomeric forms thereof in any ratio, or a physiologically acceptable salt thereof.