Patent ID: 7238698

Claim:
A compound having the Formula (I): or an isomer, prodrug, or pharmaceutically-acceptable salt thereof, wherein: Q is —C(R 1 R 2 R 3 ); R 1 is selected from hydrogen, alkyl, hydroxyalkyl, and alkoxyalkyl; R 2 and R 3 are selected: (i) independently from: (a) hydrogen, provided if R 1 is hydrogen, only one of R 2 and R 3 may be selected from hydrogen; (b) alkyl; (c) alkyl substituted with one, two, or three of halogen, cyano, —OR 8 , —SR 8 , —C(═O)R 8 , —C(O) 2 R 8 , —C(═O)NR 8 R 9 , —S(O) p R 10 , —C(O) 2 NR 8 R 9 , —S(O) 2 NR 8 R 9 , and/or —NR 8 R 9 ; (d) —OR 3 , —SR 8 , —C(═O)R 8 , —C(O) 2 R 8 , —C(═O)NR 8 R 9 , —S(O) p R 10 , —C(O) 2 NR 8 R 9 , and —S(O) 2 NR 8 R 9 ; (e) cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, cycloalkylalkyl, substituted cycloalkylalkyl, heterocycloalkyl, and substituted heterocycloalkyl; or alternatively, (ii) R 2 and R 3 are taken together to form an optionally-substituted cycloalkyl or heterocyclyl ring; R 4 and R 5 are independently selected from hydrogen, halogen, cyano, haloalkyl, and haloalkoxy, provided R 4 and R 5 are not both hydrogen; R 6 may be attached to carbon atoms C5, C7, and/or C8 of the quinazoline ring, and when attached to carbon atom C5 is lower alkyl and when attached to C7 and/or C8 is independently selected from alkyl, halogen, cyano, nitro, hydroxy, alkoxy, haloalkoxy, amino, alkylamino, and alkyl substituted with one to two of halogen, cyano, nitro, hydroxy, alkoxy, haloalkoxy, amino, and/or alkylamino; R 7 is attached to any available carbon atom of the phenyl ring and at each occurrence is independently selected from alkyl, substituted alkyl, halogen, cyano, nitro, hydroxy, alkoxy, haloalkoxy, amino, and alkylamino; R 8 and R 9 are (i) independently selected from hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl; or (ii) when R 8 and R 9 are attached to the same nitrogen atom (as in —C(O) 2 NR 8 R 9 , —S(O) 2 NR 8 R 9 , and —NR 8 R 9 ), R 8 and R 9 may be taken together to form an optionally-substituted heterocyclyl ring; R 10 is alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, or substituted heterocyclyl; m is 0, 1, 2 or 3; n is 0, 1 or 2; and p is 1 or 2.