Patent ID: 8299067

Claim:
A 5-demethoxyfumagillol derivative of Formula (XI) : or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 13 is hydrogen, or unsubstituted or substituted aryl, alkyl, cycloalkyl, alkenyl, alkynyl, arylalkyl, alkylaryl, heterocycloalkyl, heteroaryl, or —(CH 2 ) k —N 3 ; Z is a bond, methylene, O, or NR 13 ; Y is —CH 2 —R 4 , —CH 2 —OR 5 , —C(═O)—R 6 or —C(═O)—OR 7 ; where each of R 4 , R 5 , R 6 and R 7 is independently H, alkyl, aryl, arylalkyl, alkylaryl, trialkylsilyl, methoxymethyl, dialkylamino, diarylamino or alkylarylamino; each of n and m is independently an integer from 0 to 5, wherein when Z is a bond, the sum of n and m is 5, when Z is methylene, O, or NR 13 , the sum of n and m is 4; and k is an integer from 1 to 10.