Patent ID: 8193241

Claim:
A compound of formula I or Ia: wherein: represents the presence of a single bond or double bond; R 1 , R 2 , R 3 , R 6 , R 7 , R 8 , and R 11 are each independently H or C 1-10 alkyl; R 4 and R 9 are each independently H or acid labile protecting group; R 5 is C 2-6 monoalkenyl or C 4-6 alkadienyl; R 10 is H, C(═O)NR 13 R 14 , or oxidatively labile hydroxyl protecting group; Q is —O—; Z is —CH— or —CH 2 —, provided that when represents a double bond, then Z is —CH—; R 12 is H, alkyl, or acid labile amino protecting group; R 13 and R 14 are each independently H, C 1-10 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, OR c , C(═O)R b , S(O) p R b , (CH 2 ) r C 3-12 carbocycle, or (CH 2 ) r heterocycle having 5 to 12 ring atoms; or R 13 and R 14 taken together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocycle containing 0-3 additional heteroatoms selected from O, S, and N; R b and R c are each independently H, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, or (CH 2 ) r phenyl; p is 1 or 2; and each r is independently 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.