Patent ID: 8173661

Claim:
A compound of Formula I-C wherein: i) A is S or O; ii) X is a single bond-or optionally substituted and saturated or unsaturated C 1 -C 4 alkylene, C 3 -C 10 cycloalkylene optionally containing one or more heteroatoms selected from a group consisting of O or N, —N(R 6 )— or —C 1 -C 4 alkyl-N(R 6 )—; iii) Y is a single bond or optionally substituted and saturated or unsaturated C 1 -C 4 alkylene, optionally substituted -aryl-, -arylalkylene-, -heteroaryl-, —C(O)—, —N(R 6 )C(O)—, —R 3 C(O)—, —R 3 -alkylamido- or —R 3 —NHC(O)—; iv) R 1 is C 1 -C 4 alkyl; v) R 3 is H or optionally substituted and saturated or unsaturated C 1 -C 4 alkyl, optionally substituted (R 6 )N—, —(R 4 )(R 5 )N—, —(R 4 )(R 5 )—C 1 -C 4 alkyl-, aryl, heteroaryl, arylC 1 -C 4 alkyl, heteroarylC 1 -C 4 alkyl, or C 3 -C 8 cycloalkyl optionally containing one or more heteroatoms selected from a group consisting of O or N; vi) R 4 and R 5 are linked together via a covalent bond so as to form a C 3 -C 8 cycloalkylene containing a nitrogen atom; vii) R 6 is H, C 1 -C 4 alkyl, aryl or arylC 1 -C 4 alkyl, in free or salt form.