Patent ID: 6900043

Claim:
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence as set forth in SEQ ID NO: 1; (b) a nucleotide sequence encoding the polypeptide as set forth in SEQ ID NO: 2; (c) a nucleotide sequence corresponding to nucleotide position number 181 to 795 in SEQ ID NO:1; (d) a nucleotide sequence which hybridizes to any of (a) or (c) under conditions of 50% formamide, 50 mM potassium phosphate, pH 6.5; 5× SSC; 1%SDS; 5× Denhardt's; 0.05% sodium sarcosyl; and 300 μg/ml salmon sperm DNA at 42° C. overnight and washed to a final stringency of 1× SSC, 0.1% SDS and 42° C., wherein the nucleotide sequence encodes a polypeptide fragment having an activity of regulating JNK activation or modulating JNK signal mediated signal transduction; and (e) a nucleotide sequence complementary to any of (a)-(c).