Patent ID: 8524654

Claim:
A method for reducing neutrophilic inflammation in a subject comprising: (a) selecting a subject with neutrophilic inflammation; and (b) administering to the subject an agent that inhibits the expression or activity of prolyl endopeptidase, wherein the agent that inhibits the expression or activity of prolyl endopeptidase is selected from the group consisting of a proline derivative, a pyrrolidineamide derivative, a prolinal derivative, a sulfated chitooligosaccharide, a plant phenolic, eurystatin, an inhibitory peptide, and an inhibitory nucleic acid, wherein, if the agent is a plant phenolic, the plant phenolic is selected from the group consisting of 1,2,3-trigalloyl glucopyranoside, 1,2,6-trigalloyl glucopyranoside, 1,2,3,4,6- pentagalloyl gluco-pyranoside, 1,2,6-trigalloyl alloside, 1,3,6-trigalloyl alloside, 1,2,3,6-tetragalloyl alloside, acetonyl geraniin, corilagin, elaeocarpusin, euphorscopin, geraniin, helioscopin B, helioscopinin A, helioscopinin B, jolkinin, macranganin, rugosin E, supinanin, and teracatain.