Patent ID: 7989472

Claim:
A a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein: Ring A represents a 6-10 membered Aryl group or a 5-10 membered heteroaryl or partially aromatic heterocyclic group containing 1-4 heteroatoms, 0-4 of which are N atoms, and 0-1 of which are O or S atoms; two R 1 and two R 2 groups are present and represent hydrogen, or one or two R 1 and R 2 groups are selected from (a), (b) and (c) below: (a) halo, OH, CO 2 R 4 , SO p R 5 , CN, NO 2 C(O)NR 6 R 7 or NR 6 R 7 ; (b) C 1-10 alkyl, C(O)C 1-10 alkyl, OC 1-6 alkyl, C 2-6 alkenyl, the alkyl portions being optionally substituted with: (1) 1-5 halo groups, up to perhalo, and 1-2 OH groups; (c) a 6-10 membered Aryl, O-Aryl or S-Aryl group, or a 5-10 membered HAR, O-HAR or S-HAR group containing 0-4 nitrogen and 0-1 O or S atoms, said group being optionally substituted with 1-3 groups selected from (a) and (b) above, or two R 2 groups can be taken together in combination and represent a methylene or ethylene bridge forming a carbocyclic ring containing 5 or 6 atoms, or a fused phenyl ring optionally substituted with 1-3 halo groups and 1-2 CN, SO p R 5 , C 1-3 alkyl, C 1-3 alkoxy, haloC 1-3 alkyl, haloC 1-3 alkoxy groups, and the R 1 groups represent H or are selected from (a) through (c) above; four R 3 groups are present as follows: 1) 0-1 R 3 group is selected from the group consisting of: Aryl, HAR, —(CH 2 ) 1-4 Aryl, —(CH 2 ) 1-4 HAR, —X-Aryl, —X-HAR, —X—C 1-4 Alkyl-Aryl and —X—C 1-4 Alkyl-HAR; wherein X represents O, S, S(O) or S(O) 2 ; said Aryl and HAR groups and portions of the groups above being optionally substituted with 1-4 halo atoms, and 1-2 members selected from: OH, CN, C 1-6 alkyl, OC 1-6 allyl, haloC 1-6 allyl, OC 1-6 haloalkyl, NO 2 , SO p R 5 , C 2-6 alkenyl, OC 2-6 alkenyl, NR 6 R 7 and HAR; 2) 0-3 R 3 groups are selected from: OH, CN, oxo, NO 2 , SO p R 5 , NR 6 R 7 , C 1-10 alkyl, haloC 1-10 alkyl, OC 1-10 alkyl, OC 1-10 haloalkyl, C 2-10 alkenyl, OC 2-6 alkenyl and haloC 2-4 alkenyl, and 3) the remaining R 3 groups are H or halo atoms; R 4 is H or C 1-6 alkyl, and R 5 represents a member selected from the group consisting of: C 1-10 alkyl, Aryl or Ar—C 1-4 -alkyl; R 6 and R 7 each independently represent H or C 1-6 alkyl; n represents an integer of from 0-5; p is 0, 1 or 2; R a represents CH 2 CH 2 CO 2 R 4 , CH 2 CH(OH)CO 2 R 4 or 5-tetrazolyl; and R b is H or is selected from the group consisting of: halo, CN, NO 2 , OH, C 1-3 alkyl, OC 1-3 alkyl, haloC 1-3 alkyl and haloC 1-3 alkoxy.