Patent ID: 8389692

Claim:
An isolated antibody or antigen-binding fragment thereof that specifically binds to loop 9 in domain 2 of human platelet glycoprotein VI (GPVI) protein, wherein said antibody or antigen-binding fragment thereof comprises a variable heavy chain (VH) with 3 complementarity determining regions (CDR) and a variable light chain (VL) with 3 complementarity determining regions (CDR), comprising the following VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3, respectively of: (i) SEQ ID NOs: 18, 19, 20, 54, 55 and 56; (ii) SEQ ID NOs: 24, 25, 26, 60, 61 and 62; (iii) SEQ ID NOs: 48, 49, 50, 84, 85 and 86; (iv) SEQ ID NOs: 362, 363, 364, 404, 405, and 406; and (v) SEQ ID NOs: 365, 366, 367, 407, 408, and 409.