Patent ID: 7498354

Claim:
A compound represented by Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof, wherein A is C 0-6 alkyl or —NR 1 R 11 ; E is —CO 2 R 2 , —CONR 12 R 21 , —C(R a R b )OR 212 , or —C(R a R b )NR 12 R 2 ; D is aryl or hetaryl; G is C 0-6 alkyl, halogen, optionally substituted cyclyl, optionally substituted heterocyclyl, —OR 22 , —NR 13 R 22 , —CN or —CF 3 ; R 1 , R 11 , R 12 , R 212 , and R 13 each independently is C 0-6 alkyl, —COR 14 , —CONR 14 R 15 , or —S(O) n NR 14 R 15 ; R 14 and R 15 each independently is C 0-6 alkyl, —CO(C 0-6 alkyl), —CON(C 0-6 alkyl)(C 0-6 alkyl), or —S(O) m N(C 0-6 alkyl)(C 0-6 alkyl); R 2 and R 22 each independently is C 1-8 alkyl optionally substituted with a heterocyclyl; —C 0-8 alkyl-C 3-8 cycloalkyl, —C 2-8 alkyl-O—C 0-8 alkyl, —C 2-8 alkyl-N(C 0-8 alkyl)(C 0-8 alkyl), —C 2-8 alkyl-S(O) 0-2 —C 0-8 alkyl; or heterocyclyl optionally substituted with C 0-8 alkyl, cyclyl or substituted cyclyl substituent; R 21 is C 0-8 alkyl optionally substituted with a heterocyclyl; R 21 is —C 0-8 alkyl-C 3-8 cycloalkyl, —C 2-8 alkyl-O—C 0-8 alkyl, —C 2-8 alkyl-N(C 0-8 alkyl)(C 0-8 alkyl), or —C 2-8 alkyl-S(O) 0-2 —C 0-8 alkyl; or R 21 is heterocyclyl optionally substituted with C 0-8 alkyl, cyclyl or substituted cyclyl substituent; R a and R b are each independently C 0-8 alkyl or C 3-8 cycloalkyl; or R a and R b taken together with the C to which they are attached form a saturated or partially unsaturated 3-10 membered ring optionally containing 0-4 N, O, S, SO, or SO 2 at the ring nodes, provided that no N, O or S atoms are placed adjacent to each other at ring nodes; and n and m each independently is 0, 1, or 2.