Patent ID: 8188073

Claim:
A compound of the following formula [I]: wherein Ring A is a benzene ring optionally substituted by one to three groups(s) selected from (a) a halogen atom, (b) a C 1-6 alkyl group (said alkyl group being optionally substituted by one to three group(s) selected from a halogen atom, a hydroxyl group and a C 1-6 alkoxy group), (c) a hydroxyl group; (d) a C 1-6 alkoxy group, (e) an amino group, (f) a cyano group, (g) a C 2-12 alkenyl group (h) a C 1-7 alkanoyl group and (j) a C 3-10 cycloalky group, R 1 is a group of the formula: R a SO 2 NH—, R a SO 2 NH—CH 2 — or (R b )(R c )NSO 2 — and said R 1 substituting at 7-position of 1,4-benzothiazine moiety, R a is a C 1-6 alkyl group, a C 3-10 cycloalkyl group, an amino group optionally substituted by one or two C 1-16 alkyl group(s), a 6- to 10-member monocyclic or bicyclic aryl group or a 5- to 10-membered monocyclic or bicyclic heteroaryl group containing one to two heteroatom(s) selected from an oxygen atom, a sulfur atom and a nitrogen atom, R b and R c are the same or different and are each a hydrogen atom, a C 1-6 alkyl group or a C 3-10 cycloalkyl group, one of R 2 and R 3 is a hydrogen atom, a halogen atom or a C 1-6 alkyl group, and another is a hydrogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy-carbonyl group or a phenyl group, or both of them combine each other together with the adjacent carbon atom to form a C 3-10 cycloalkyl group, X is a sulfur atom, Y is a group of the formula: —C(═O)—, —C(═S)— or —CH(R 5 )—, R 5 is a hydrogen atom or a phenyl group, Ar is a 6- to 10-membered mono- or bi-cyclic aryl group and said aryl group being optionally substituted by one to three group(s) selected from (a) a halogen atom, (b) a hydroxyl group, (c) a cyano group, (d) a C 1-6 alkyl group optionally substituted by one to three halogen atom(s), (e) a hydroxy-C 1-6 alkyl group, (f) a benzoyloxymethyl group, (g) a C 1-6 alkoxy group optionally substituted by one to three halogen atom(s), (h) a C 1-6 alkoxy-carbonyl-C 1-6 alkoxy group, (i) a C 1-6 alkylthio group, (j) a C 1-6 alkylenedioxy group optionally substituted by one to two halogen atom(s), (k) an amino group optionally substituted by one to two C 1-6 alkyl group(s), (l) an acylamino group (said acyl group being a C 1-7 alkanoyl group or benzoyl group), (m) a C 3-10 cycloalkyl group and (n) a C 1-6 alkylsulfonyl group, and Q is a single bond, a C 1-6 alkylene group or a C 1-6 alkenylene group, or a pharmaceutically acceptable salt thereof.