Patent ID: 7157585

Claim:
A tryptase inhibitor compound of formula (I) where: R 5 represents amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen; R 6a represents hydrogen or methyl; X—X is selected from the group consisting of —CH═CH—, —CONR 1a —, —NH—CO—, —NR 1a —CH 2 —, —CH 2 —NR 1a —, —CH 2 O—, —OCH 2 —, —COO—, —OC═O— and —CH 2 CH 2 —; R 1a represents hydrogen, (1–6C)alkyl or phenyl(1–6C)alkyl; L is CO or CONR 1d (CH 2 ) m in which m is 0 or 1 and R 1d is hydrogen, (1–6C)alkyl or phenyl(1–6C)alkyl; Cy is phenyl optionally substituted by R 3a or R 3i X i in which X i is a bond, O, NH or CH 2 and R 3i is phenyl optionally substituted by R 3a ; each R 3a independently is hydrogen, hydroxyl, (1–6C)alkoxy, (1–6C)alkyl, (2–6C)alkenyl, (2–6C)alkynyl, (1–6C)alkanoyl, (1–6C) alkylaminoalkyl, hydroxy(1–6C)alkyl, carboxy, (1–6C) alkoxyalkyl, (1–6C) alkoxycarbonyl, (1–6C) alkylaminocarbonyl, amino(1–6C)alkyl CONH 2 , CH 2 CONH 2 , aminoacetyl, (1–6C)alkanoylamino, (1–6C) alkoxycarbonylamino, amino, halo, cyano, nitro, thiol, 1–6C) alkylthio, (1–6C) alkylsulphonyl, (1–6C) alkylsulphenyl, imidazolyl, hydrazido, (1–6C) alkylimidazolyl, (1–6C) alkylsulphonamido, (1–6C) alkylaminosulphonyl, aminosulphonyl, (1–6C) haloalkoxy, or (1–6C) haloalkyl; X i is a bond, O, NH or CH 2 ; and R 3i is phenyl optionally substituted by R 3a ; and Lp is a heterocyclic group, or a combination of a heterocyclic group and one or more alkyl, alkenyl, carbocyclic or heterocyclic groups linked by a spiro linkage or a single or double bond or by C═O, O, OCO, COO, S, SO, SO 2 , CONR 1e , NR 1e —CO— or NR 1e linkage (where R 1e is as defined for R 1a ), optionally substituted by one or more oxo or R 3 groups in which R 3 is an amino acid residue, N-(1–6C)alkylaminocarbonyl, N,N-di(1–6C)alkylaminocarbonyl, N-(1–6C)alkylaminoalkanoyl, N-(1–6C)alkanoylamino(1–6C)alkanonyl, C-hydroxyamino(1–6C)alkanoyl, hydroxy(2–6C)alkanoylamino(1–6C)alkanoyl, di(1–6C)alkylaminosulfonyl, hydrogen, hydroxyl, (1–6C)alkoxy, (1–6C)alkanoyloxy, (1–6C) alkyl, (2–6C) alkenyl (2–6C)alkynyl, (3–6C)alkenyloxycarbonyl, (1–6C)alkanoyl, amino(1–6C)alkyl, amido (CONH 2 ), amino(1–6C)alkanoyl, aminocarbonyl(1–5C)alkanoyl, hydroxy(1–6C)alkyl, carboxy, hydroxy(1–6C)alkanoyl, (1–6C)alkoxy(1–6C)alkyl, (1–6C)alkoxycarbonyl(1–5C)alkyl, (1–6C)alkoxycarbonyl, (1–6C)alkanoylamino, amino, halo, cyano, nitro, thiol, (1–6C)alkylthio, (1–6C)alkylsulfonyl, (1–6C)alkylsulphenyl or hydrazido; or a physiologically tolerable salt thereof.