Patent ID: 7268146

Claim:
A compound of Formula I or Formula II: wherein: R 1 is —CR c R d R e or —C(O)NR a R b ; R 2 is C 1-6 alkyl; R 3 and R 4 are hydrogen; Ar is aryl or pyridine optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, C1-6 alkoxy, halogen and NR a′ R b′ wherein R a′ and R b′ are independently hydrogen or C 1-6 alkyl; R a and R b taken together with the nitrogen to which they are attached form a heterocyclyl ring selected from the group consisting of pyrrolidine, piperidine, homopiperidine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, hexahydropyrimidine, piperazine and morpholine, where each of said rings is optionally substituted with one or more substituents selected from the group consisting of hydroxy, oxo, alkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, aminoalkyl, acyl, acylamino, aminocarbonyl, aminocarbonylalkyl, aminocarbonylamino, aminosulfonyl, alkylsulfonylamino; R c is hydrogen, hydroxy or —NR a″ R b″ ; R e is heterocyclyl or heteroaryl said heteroaryl groups optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, haloalkyl, C 1-6 alkoxy, amino, alkylamino, dialkylamino, and halogen and R d is hydrogen or C 1-6 alkyl; or R c and R d are taken are C 1-6 alkylidenyl; or R d and R e are taken together with the carbon to which they are attached to form a heterocyclyl ring; R e″ and R b″ are taken together with the nitrogen to which they are attached form an heterocyclyl or heteroaryl ring selected from the group consisting of pyrrolidine, piperidine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, hexahydropyrimidine, piperazine, morpholine, imidazoline where each of said rings is optionally substituted with one or more substituents selected from the group consisting of hydroxy, oxo, alkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, aminoalkyl, acyl, acylamino, aminocarbonyl, aminocarbonylalkyl, aminocarbonylamino, aminosulfonyl, alkylsulfonylamino, aminosulfonylamino; n is 1; a is a single bond; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts thereof.