Patent ID: 7842515

Claim:
A nano-structured support for analysis or/and separation, said nano-structured support comprising a nano-structured region, said nano-structured region comprising a solid phase support and a nano-structure fixed on said solid phase support, said nano-structure comprising non-aligned nano-structure units, said nano-structure units including nano-convex portions with a height over 3 nm, which cross-section at its half-height presents at least one dimension as 1-500 nm, wherein said nano-structured region has: 1) a distribution density of said nano-convex portions of more than 10 convexes/μm 2 ; 2) a sensibility-increasing rate of more than 200%; and 3) any one or more of the following characteristics: (1) a nano-structure covering rate of more than 30%; (2) a surface-increasing rate of more than 400%; (3) an adsorption-increasing rate of more than 150%; and (4) an adsorption-attenuating rate of less than 80%, wherein said analysis or/and separation includes polypeptide or/and polypeptide-related-drug analysis or/and separation, wherein said nano-structure includes: (1) an inorganic nano-particle at least including: silica nano-particle or alumina oxide nano-particle; and/or 2) an organic nano-particle; and/or 3) a derivative of the inorganic and/or the organic nano-particle, which includes a derivative of inorganic and/or organic nano-particle which has bound chemical surface group and/or a coated organic compound; wherein said bound chemical surface group includes one or more of following chemical surface groups selected from the group consisting of amino-, aldehyde-, epoxy-, amino diazane, diethylaminoethyl, diethyl- (2-hydroxyproptyl) aminoethyl, carboxymethyl, sulfopropyl, mercaptoethylpyridine, siloxanyl, thioalcohol- and alkyl-; wherein said coated organic compound includes one or more of the following substances: (1) a surfactant including polyvinylpyrrolidone and/or nonionic surfactant; (2) a polyelectrolyte including polyamino acid; (3) an oleophilic compound including polysiloxane; (4) an ion exchange polymer including dextran derivative, agarose derivative, cellulose derivative, and/or polyacrylamide; or (5) affinity materials including heparin natrium, antigen and/or antibody; wherein said nano-structure units are in the shape of a tree branch and wherein said nanostructure support is prepared by the steps comprising 1) contacting a suspension of nano-particles with said support; and 2) fixing said nano-particles on said support, wherein said suspension has a concentration of from 1/20000 to 1/60000 g/ml in nano-particle weight/volume concentration.