Patent ID: 7405300

Claim:
A compound, including enantiomers, stereoisomers, and tautomers of said compound and pharmaceutically acceptable salts solvates or derivatives thereof, with said compound having the general structure shown in formula (I): wherein R is hydrogen, hydroxy, C 1-4 alkoxy or amino; R 1 is naphthyl, substituted phenyl, C 6-12 arylC 1-4 alkyl, C 6-12 arylsulfonyl or heteroaryl, and wherein said naphthyl, aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkenyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, C 1-4 alkoxy, C 1-4 thioalkyl, hydroxy, hydroxyC 1-4 alkyl, C 1-4 acyloxy, nitro, amino, C 1-4 alkylamino, C 1-4 dialkylamino, aminoC 1-4 alkyl, C 1-4 alkylaminoC 1-4 alkyl, C 1-4 dialkylaminoC 1-4 alkyl, —CN, —CO 2 H, —CO 2 C 1-4 alkyl, —NHCOC 1-4 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted phenoxy, substituted or unsubstituted benzyloxy, substituted or unsubstituted pyrrolyl and substituted or unsubstituted pyridyl; R 2 and R 3 are the same or different and are each independently selected from: hydrogen, C 1-4 alkyl, C 1-4 dialkylaminoC 1-4 alkyl, pyrrolidinylC 1-4 alkyl, imidazolyl or heterocycle selected from morpholinyl, thiomorpholinyl, aziridinyl, pyrrolidinyl, piperidinyl, azepanyl, piperazinyl, diazepanyl, diazabicyclo[2.2.1]hept-2-yl and triazocanyl; and wherein said heterocycle is optionally substituted with one or more substituents selected from the group consisting of C 1-4 alkyl, oxo, —CHO and —CO 2 C 1-4 alkyl; or R 2 and R 3 taken together with the nitrogen atom to which they are attached form an imidazolyl or a heterocycle selected from morpholinyl, thiomorpholinyl, aziridinyl, pyrrolidinyl, piperidinyl, azepanyl, piperazinyl, diazepanyl, diazabicyclo[2.2.1]hept-2-yl and triazocanyl; and wherein said heterocycle is optionally substituted with one or more substituents selected from the group consisting of C 1-4 alkyl, oxo, —CHO, —CO 2 C 1-4 alkyl, hydroxyC 1-4 alkyl, oxiranylC 1-4 alkyl, dihydroxyC 1-4 alkyl, —(CH 2 ) a N—CO 2 C 1-4 alkyl, hydroxyl, and —(CH 2 ) a OPO(OC 1-4 alkyl) 2 , wherein a is an integer from 1 to 4; R 4 is C 1-4 alkyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, C 1-4 alkoxy or C 1-4 thioalkyl; and X and Y are CH.