Patent ID: 7442709

Claim:
A compound represented by Formula (I) wherein: R1 is —NR 3 R 31 , —NR 3 C(O)R 31 , —NR 3 C(O)OR 31 , —NR 3 SO 2 R 31 , —OR 3 , —SR 3 , —SO 2 R 3 , —CO 2 R 3 , —CO 2 H, —CO—NR 3 R 31 , —N(C 0-8 alkyl)(C 0-8 alkyl), or —CN, group; R2 is H, —C 0-8 alkyl, or —C 3-10 cycloalkyl; X is a cyclyl or heterocyclyl group optionally substituted with 1 or more substituents chosen from H, halogen, NR 32 R 33 , NR 32 COR 33 , NR 32 CO2R 33 , NR 32 SO 2 R 33 OR 32 , SR 32 , SO 2 R 32 , SO 2 NR 32 R 33 , CO 2 R 32 , CO 2 H, CONR 32 R 33 , —C 0-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, CN, CF 3 , OCF 3 , NO 2 , oxo, cyclyl or a heterocyclyl group; Y is absent; wherein the point of attachment to X can be from either the left or the right of the linkers as shown; Z is a cyclyl or heterocyclyl group, optionally substituted with 1 or more substituents chosen from halogen, NR 34 R 35 , NR 34 COR 35 , NR 34 CO2R 35 , NR 34 SO 2 R 35 , OR 34 , SR 34 , SO 2 R 34 , SO 2 NR 34 R 35 , CO 2 R 34 , CO 2 H, CONR 34 R 35 , —C 0-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, CN, CF 3 , NO 2 , oxo, cyclyl or a heterocyclyl group; and R 3 , R 31 , R 32 , R 33 , R 34 and R 35 are independently C 0-8 alkyl optionally substituted with a heterocyclyl or OH substituent; —C 0-8 alkyl-C 3-8 cycloalkyl, CF 3 , —C 0-8 alkyl-O—C 0-8 alkyl, —C 0-8 alkyl-N(C 0-8 alkyl)(C 0-8 alkyl), —C 0-8 alkyl-S(O) 0-2 —C 0-8 alkyl; or heterocyclyl optionally substituted with —C 0-8 alkyl, cyclyl or substituted cyclyl substituent; or a pharmaceutically acceptable salt or N-oxide thereof.