Patent ID: 8741948

Claim:
A controlled release oral pharmaceutical composition comprising: (1) a tablet core comprising a homogeneous structure comprising (a) rifamycin SV, (b) a hydrophilic substance, (c) a lipophilic substance, and (d) an amphiphilic substance; and (2) a coating on said tablet core, said coating comprising a gastro-resistant substance, wherein said controlled release oral pharmaceutical composition comprises from about 10% to about 90% by weight of rifamycin SV, and wherein said controlled release oral pharmaceutical composition provides an in vitro release rate of said rifamycin SV in a buffer at pH 7.2 such that less than about 20% of said rifamycin SV is released after about 1 hour and more than about 70% of said rifamycin SV is released after about 8 hours.