Patent ID: 8637531

Claim:
A pyrido(3,2-d)pyrimidine derivative represented by the structural formula: wherein: R 1 is amino, R 2 is selected from the group consisting of C 1-6 alkyl thio-C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 3-10 cycloalkenyloxy, C 3-10 cycloalkenyl-C 1-6 alkoxy, C 1-6 alkylsulfonyl C 1-6 alkoxy, arylsulfonyl C 1-6 alkoxy, 2-propoxyethoxy, 2-ethoxy-1-propoxy, 2-isopropoxyethoxy, 2,2-difluoroethoxy, cyclobutoxy, cyclopentylmethoxy, 1-cyclopropylethoxy, 2-cyclopropylethoxy, cyclopentoxy, 3-methyl-3-methoxybutoxy, tetrahydrofuranyl-oxy, 1-ethylpropoxy, morpholinyl-propoxy, morpholinylbutoxy, cyclohexyloxy, tetrahydro-pyranoxy, tetrahydropyranmethoxy, tetrahydrofuranmethoxy, 1-methoxy-2-propoxy and oxetan-3-yloxy; R 3 is selected from the group consisting of halogen, heterocyclic and aryl groups, wherein said heterocyclic or aryl groups are optionally substituted with one or more substituents selected from the group consisting of amino, amino-C 4-4 alkyl, acyl, di-C 1-4 alkylaminocarbonyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkyl, carboxylic acid, hydroxy, halogen, halo-C 1-4 alkyl, hydroxy-C 1-4 alkyl, halo-C 1-4 alkoxy, C 2-8 alkenyl, C 1-2 alkylenedioxy, C 1-4 alkylsulfonyl, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbonyl-amino di-C 1-4 alkylamino, di-C 1-4 alkylamino-C 1-4 alkyl, aryl, aryl-C 1-4 alkoxy, aryloxy, formyl, heterocyclic, heterocyclic-oxy, tri-C 1-4 alkylammonium-C 1-4 alkyl, C 1-4 alkylcarbonyl, C 1-4 alkylcarbonylamino, arylsulfonyl and heterocyclic-substituted C 1-4 alkyl, and R 4 is hydrogen, or a pharmaceutical acceptable addition salt or a stereochemical isomeric form thereof or a N-oxide thereof.