Patent ID: 7829708

Claim:
A pharmaceutical composition comprising a compound of the formula: or its pharmaceutically acceptable salt, wherein: if Y 1 and Y 2 are both oxygen, and V 1 and V 2 are both oxygen, then at least two of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are not H; X is CH 2 , CHCH 3 , CH(CH 2 CH 3 ), NH, NCH 3 , or NR 7 ; R 1 , R 2 , R 3 , R 4 , and R 7 are independently selected from H, optionally substituted alkyl, optionally substituted alkenyl or alkynyl, acyl, —C(O)-(alkyl), —C(O)-(alkenyl), —C(O)-(alkynyl), —C(═Y 3 )V 3 , lipid, phospholipid, carbohydrate, peptide, cholesterol, an amino acid residue, or an amino acid acyl residue; R 5 and R 6 are independently selected from H, optionally substituted alkyl, optionally substituted alkenyl or alkynyl, lipid, phospholipid, carbohydrate, peptide, cholesterol, an amino acid residue, or other pharmaceutically acceptable leaving group that is capable of providing a —C(═Y)V − or —C(═Y)VH moiety when administered in vivo; each Y 1 , Y 2 , and Y 3 independently is O, S, or NJ 1 ; each V 1 and V 2 independently is O, S, or NJ 1 ; each V 3 independently is OH, OJ 1 , SH, SJ 1 , NH 2 , NHJ 1 , NJ 1 J 2 , CH 3 , CH 2 R 101 , CHR 101 R 102 , or CR 101 R 102 R 103 ; each J 1 and J 2 independently are hydrogen, alkyl, alkenyl, alkynyl, alkaryl, cycloalkyl, aryl, cycloaryl, heteroalkyl, heterocycle, heteroaryl, hydroxyl, alkoxy, or amine; and each R 101 , R 102 , and R 103 are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, acyl, heteroaryl, heteroalkyl, hydroxyl, alkoxy, cyano, azido, halogen, nitro, SO 2 , SO 3 , thioalkyl, or amino; and a pharmaceutically acceptable carrier selected from microcrystalline cellulose or cyclodextrin.