Patent ID: 8859761

Claim:
A process for refining cefamandole nafate comprising the following steps: 1) loading a cefamandole nafate into an ion exchange resin with sulfonic acid group in a polymeric substrate of cross-linked structure, followed by eluting the resin, and collecting the eluate concentrated by a reduced pressure to produce a primary purified cefamandole acid; 2) neutralizing the primary purified cefamandole acid with an aqueous solution of sodium hydroxide or an aqueous solution of basic salt of sodium, followed by adjusting the pH and removing insoluble substances with heat, which yields a secondary purified aqueous solution of cefamandole nafate; and 3) producing a tertiary purified cefamandole nafate by adding ethanol into the secondary purified aqueous solution of cefamandole nafate at the ratio of 4:6 for the ethanol to the secondary purified aqueous solution by volume and by recrystallizing with adjusting temperature.