Patent ID: 8216610

Claim:
A swallow formulation comprising paracetamol particles having a volume median diameter (D 50 ) of less than 350 μm and a surface area of greater than 0.07 m 2 g −1 , a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake into the formulation; wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37° C., wherein the weight ratio of the paracetamol and the pH modulating agent is between 1.8:1 and 2.5:1 and the weight ratio of the agent which facilitates water uptake into the formulation and the pH modulating agent is between 0.5:1 and 1.5:1.