Patent ID: 6960578

Claim:
A compound of the formula: wherein X is a single bond R 1 is selected from the group consisting of unsubstituted lower cycloalkyl or cycloalkyl substituted with oxygen, unsubstituted benzoyl or benzoyl substituted with a substituent selected from the group consisting of lower alkyl, lower alkyl substituted by halogen and halogen, unsubstituted phenyl, phenyl substituted by a substituent selected from the group consisting of hydroxy, lower alkyl, lower alkyl substituted by halogen, lower cycloalkyl, lower alkoxy, lower alkoxy substituted by halogen and cyano, styrenyl, phenylethyl, napthyl, biphenyl, benzofuranyl, an unsubstituted 5- or 6-membered heterocyclic ring, a 5- or 6-membered heterocyclic ring substituted by a substituent selected from the group consisting of oxo, benzoyl, methanesulfonyl, benzenesulfonyl and acetyl; and R 3 is selected from the group consisting of unsubstituted phenyl, and substituted phenyl, said substituted phenyl, being substituted by a substituent selected from the group consisting of halogen, cyano, nitro, azido, hydroxy, carboxy, morpholine-4-carbonyl, carbamoyl, thiocarbamoyl, N-hydroxycarbamoyl, trimethylsilyl-ethynyl, lower alkyl, lower alkynyl, lower alkoxy, halo-lower alkyl, 4-lower alkyl-piperazine-1-carbonyl, lower alkylaminocarbonyl, or lower alkyl, lower alkynyl, lower alkoxy, halo-lower alkyl, 4-lower alkyl-piperazine-1-carbonyl, lower alkylaminocarbonyl substituted by a substituent selected from the group consisting of amino, lower alkylamino, acylamino, oxo, hydroxy; lower alkoxy, lower alkylthio, unsubstituted carboxy, esterified and amidated carboxy, an unsubstituted 5-membered aromatic heterocycle, a 5-membered aromatic heterocycle substituted by a substituent selected from the group consisting of amino, lower alkylamino, acylamino, oxo, hydroxy, lower alkoxy, lower alkylthio, carboxy, carboxy esterified with lower alkyl, carboxy amidated with lower alkylamino which is eventually substituted by hydroxy, lower alkyl, lower alkyl substituted by a substituent selected from the group consisting of halogen, hydroxy, amino, lower alkylamino, acylamino, amidino and amidino substituted by a substituent selected from the group consisting of lower alkyl, —C(NRR′)═NR″ wherein R, R′ and R″ are hydrogen or lower alkyl, hydroxy, lower alkoxy, lower alkylthio, acyloxy, lower alkylsulfinyl, lower alkylsulfonyl, lower alkoxy-lower alkylsulfanyl, lower alkylsulfanyl, cycloalkylsulfinyl, cycloalkylsulfonyl, hydroxyimino, lower alkoxyimino, lower alkenyl, oxo, cyano, carbamoyloxy, sulfamoyl and sulfamoyl substituted by lower alkyl; and or a pharmaceutically acceptable acid addition salt thereof.