Patent ID: 8629125

Claim:
A pharmaceutical composition comprising a compound having the following formula: or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient; wherein: (i) Z 1 and Z 2 are —OR. (ii) Z 1 and Z 2 taken together with the boron atom form a 5- to 8—membered ring having at least one O atom directly attached to the boron, wherein the ring is comprised of carbon atoms and optionally one or more additional heteroatoms independently selected from the group consisting of N, S, and O, wherein the 5- to 8—membered ring is optionally substituted with one or more C 1-6 aliphatic group; each R is hydrogen or an optionally substituted C 1-6 aliphatic or, C 6-12 aryl group; X is a (CH 2 ) 1-6 wherein one methylene unit of X is replaced with —O— and X is attached to the para position of the phenyl group relative to the boron atom; each occurrence of R 1 is, independently, halogen, —OR, —CF 3 , —CN, —NO 2 , —NC, —SO 2 R, —SOR, —C(O)R, —CO 2 R, —C(O)N(R′) 2 , —CHO, —N 3 , —N 2 R, —N(R′) 2 , —B(OH) 2 , or an optionally substituted C 1-8 aliphatic group; each instance of R 2 is, independently, halogen, —OR, —CF 3 , —NO 2 , —NC, —SO 2 R, —SOR, —C(O)R, —CO 2 R, —C(O)N(R′) 2 , —N 2 R, —N(R′) 2 , an optionally substituted C 1-8 aliphatic or C 6-12 aryl group; wherein each R′ is hydrogen, —C(O)R, or an optionally substituted C 1-6 aliphatic group; and each instance of n and m is, independently, 0 to 4.