Patent ID: 8404647

Claim:
A compound capable of inhibiting the activity of a PAD comprising a peptide part and a thiol-reactive electrophilic group carried by an amino acid Ω wherein: (a) the peptide part comprises at least about 5 amino acids and no more than about 20 amino acids, (b) the peptide comprises at least one of the motifs (b1), (b2), (b3) or (b4): (b1) G/S/T-D/S-Ω-D/G/S-G/S (b2) H/K/F/L/W-S/D/H-Ω-D/E-H/Y/F/W (b3) Y/A/K/H/L-F/Y/H-Ω-N/G/H/Y-K/A/F (b4) Y-D/S-Ω-D/G/S-G/S in which Ω represents an amino acid carrying a thiol-reactive electrophilic group; (c) optionally the N-terminus and/or C-terminus of the peptide sequence are modified; and wherein the thiol-reactive electrophilic group is an halogeno-amidine group.