Patent ID: 8367061

Claim:
An anti-idiotype monoclonal antibody or a fragment thereof, comprising at least a variable portion of a light chain and a corresponding variable portion of a heavy chain, wherein the anti-idiotype monoclonal antibody or fragment thereof is capable of: specifically reacting with an idiotype of human anti-gp120 antibodies, inhibiting binding between a gp120 antigen and human anti-gp120 antibodies, and evoking a neutralising anti-gp120 immune response in an animal, to which the anti-idotype monoclonal antibody or fragment thereof is administered, and wherein said variable portion of the light chain and corresponding variable portion of the heavy chain are selected to have the amino acid sequence identified as SEQ ID NO:2 and SEQ ID NO:1 respectively; or have the amino acid sequence identified as SEQ ID NO:4 and SEQ ID NO:3, respectively.