Patent ID: 7838543

Claim:
A compound of formula I wherein: X is O, or S; q is 0 or 1 for R 2 other than hydrogen; Ar 1 is a phenyl group optionally substituted with one to four groups independently selected from C 1 -C 8 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, hydroxy, C 1 -C 8 alkoxy, phenyl, aryl, —O-aryl, —O-heteroaryl, —O-heterocyclic, heteroaryl, cycloalkyl, C 1 -C 4 alkylaryl, C 1 -C 4 alkylheteroaryl, C 1 -C 4 alkyl-O-aryl, C 1 -C 4 alkyl-O-heteroaryl, C 1 -C 4 alkyl-O-heterocyclic, C 1 -C 4 alkylcycloalkyl, cyano, —(CH 2 ) n NR 6 R 6′ , C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, halo, (CH 2 ) n COR 6 , (CH 2 ) n NR 6 SO 2 R 6′ , —(CH 2 ) n C(O)NR 6 R 6′ , heterocyclic, and C 1 -C 4 alkylheterocyclic; wherein the cycloalkyl, phenyl, aryl, heteroaryl and heterocyclic substituent are each optionally substituted with one to three groups independently selected from hydroxy, C 1 -C 6 alkoxy, C 1 -C 4 alkoxyalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl, nitro, cyano, amino, carboxamido, phenyl, aryl, alkylheterocyclic, heterocyclic, and oxo; L 1 is a bond, or a divalent linker selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and —OC 1 -C 6 alkyl; R 1 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl and C 1 -C 4 alkylcycloalkyl; R 2 is independently selected from the group consisting of hydrogen, halo, C 1 -C 4 haloalkyl, C 1 -C 4 alkyl, and C 1 -C 4 alkoxy; R 3 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, C 1 -C 4 alkylaryl, C 1 -C 4 alkylcycloalkyl, heterocyclic and C 1 -C 4 alkylheterocyclic; L 2 is C 2 -C 4 alkyl; each R 4 and R 5 is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, C 1 -C 4 alkylaryl, C 1 -C 4 alkylheteroaryl, C 1 -C 4 alkylcycloalkyl, (CH 2 ) n C(O)C 1 -C 4 alkyl, CONR 6 R 6′ , SO 2 R 6 , heterocyclic, and C 1 -C 4 alkylheterocyclic; wherein each of the alkyl, alkenyl, cycloalkyl, aryl, or heterocyclic groups or subgroups is optionally substituted with one to three groups independently selected from C 1 -C 8 alkyl, C 2 -C 8 alkenyl, phenyl, C 1 -C 8 haloalkyl, halo, hydroxy, —OC 1 -C 8 haloalkyl, and alkylaryl; n is an integer from 0 to 4; or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diastereomers thereof.