Patent ID: 8445503

Claim:
A compound having a structure according to Formula (I): or a salt thereof, wherein: X is C or N and the dashed line represents a single or double bond; A is a ring selected from the group consisting of phenyl, pyridine, pyrimidine, pyrazine, pyridazine, pyrrole, pyrazole, imidazole, thiazole, isothiazole, isoxazole, triazole, thiadiazole, benzimidazole, indole, pyrrolo[2,3-b]pyridine, quinoline, pyrrolidine, piperidine, piperazine, and dihydro-imidazole; R 1 is methyl; R 2 is hydrogen, methyl, ethyl, —CH 2 -cyclopropyl, or —CH 2 CF 3 ; R 4 and R 3 , together with the atoms to which they are attached, are optionally joined to form a substituted or unsubstituted heterocyclic ring selected from the group consisting of wherein represents the core ring of Formula I, i.e. the N attached to R 4 and the C attached to R 3 ; R 5 is hydrogen, —Br, —CN, —CH 3 , —CH 2 CN, —CH 2 CH 2 NH 2 , —OH, —O − , ═O, —OCH 3 , —Obenzyl, —C(O)OH, —C(O)OCH 3 , —C(O)OCH 2 CH 3 , —C(O)NH 2 , —C(O)NHCH 3 , —C(O)N(CH 3 ) 2 , —NH 2 , ═NH, —NHCH 3 , —N(CH 3 ) 2 , —NHS(O) 2 CH 3 , —S(O) 2 CH 3 , phenyl, thiazole, pyridine or pyrazine; R 6 is hydrogen, —Cl, —Br, —CH 3 , —CF 3 , —CH 2 NH 2 , —NH 2 , —CH 2 NHC(O)OCH 3 , —CH 2 NHC(O)CH 3 , —CH 2 NHC(O)phenyl, —CH 2 NHS(O) 2 CH 3 , —CH 2 NHS(O) 2 phenyl, —NHC(O)CH 3 , —NHC(O)OCH 3 , —NHC(O)phenyl, —NHS(O) 2 CH 3 , —NHS(O) 2 phenyl, —CH≡CHphenyl, cyclopropyl, cyclopentenyl, benzyl, phenyl optionally substituted with 1, 2 or 3 substituents R 9 , pyridine optionally substituted with 1 fluoro, pyrimidine, pyrazine, pyridazine, pyrazole, thiazole, oxazole, thiophene optionally substituted with 1 chloro, pyrrolidine, oxazolidinone, pyrrolidinone, dihydropyran, tetrahydropyran, morpholine, 4-methyl-piperazine, pyrrolidine-dione, pyridinone, isoquinoline, or quinoline; R 7 at each occurrence is independently —C(O)NH 2 , fluoro, chloro, cyano, pyrazole, triazole, pyridine or pyrimidine; R 8 is methyl or 2-(trimethylsilyl)ethoxy)methyl, cyclopropyl, or —CH 2 -cyclopropyl; and R 9 at each occurrence is independently selected from the group consisting of fluoro, chloro, bromo, —S(O) 2 CH 3 , —OCF 3 , —CF 3 , —CN, pyridine, triazole, and pyrazole.