Patent ID: 7612055

Claim:
A compound of the formula in which R 1 is CH(R e )C(═O)N(R a )R b or (CH 2 ) k N(R c )R d , wherein k is 0, 1 or 2; R a and R b , independently, are hydrogen or an optionally substituted (C 1-8 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, aryl, aryl(C 1-4 )alkyl, heteroaryl or heteroaryl(C 1-4 )alkyl group, R c and R d , independently, are hydrogen or an optionally substituted (C 1-8 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, aryl, aryl(C 1-4 )alkyl, heteroaryl, heteroaryl(C 1-4 )alkyl, chroman-4-yl, isochroman-4-yl, thiochroman-4-yl, isothiochroman-4-yl, 1,1-dioxo-1lambda*6*-thiochroman-4-yl, 2,2-dioxo-2lambda*6*-isothiochroman-4-yl, 1,2,3,4-tetrahydro-quinolin-4-yl, 1,2,3,4-tetrahydro-isoquinolin-4-yl, 1,2,3,4-tetrahydro-naphthalen-1-yl, 1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1,2]thiazin-4-yl, 2,2-dioxo-1,2,3,4-tetrahydro-2lambda*6*-benzo[c][1,2]thiazin-4-yl, 1,1-dioxo-3,4-dihydro-1H-1lambda*6*-benzo[c][1,2]oxathiin-4-yl, 2,2-dioxo-3,4-dihydro-2H-2lambda*6*-benzo[e][1,2]oxathiin-4-yl, 2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl or 1,3,4,5-tetrahydro-benzo[c]oxepin-5-yl group, or R a and R b , or R c and R d , together with the nitrogen to which they are attached, form an optionally substituted pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or piperazinyl group; and R e is optionally substituted (C 1-8 )alkyl, (C 1-4 )alkoxy(C 1-4 )alkyl, (C 3-7 )cycloalkyl or (C 3-7 )cycloalkyl(C 1-4 )alkyl; R 2 is hydrogen or (C 1-4 )alkyl; R 3 is hydrogen, (C 1-6 )alkyl or an optionally substituted (C 1-6 )alkylOC(═O)NH, (C 3-7 )cycloalkylOC(═O)NH, (C 3-7 )cycloalkyl(C 1-4 )alkylOC(═O)NH, aryl(C 1-4 )alkylOC(═O)NH, heteroaryl(C 1-4 )alkylOC(═O)NH, (C 1-4 )alkylC(═O)NH, (C 3-7 )cycloalkylC(═O)NH, arylC(═O)NH, aryl(C 1-4 )alkylC(═O)NH, heteroarylC(═O)NH or heteroaryl(C 1-4 )alkylC(═O)NH group; U is a bond; V is CH═CH, CH 2 CH(OH), CH(OH)CH 2 or CR h R h CR h R h , wherein each R h , independently, is hydrogen, fluorine or (C 1-4 )alkyl; W is (C 1-6 )alkylene; X is an optionally substituted (C 1-4 )alkanylylidene or (C 1-4 )alkylene; Y is C(═O)NR g or N(R g )C(═O), wherein R g is hydrogen, (C 1-8 )alkyl or (C 3-7 )cycloalkyl; Z is a bond; and n is 0 to 5, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form.