Patent ID: 8338576

Claim:
An isolated antibody or immunologically functional fragment thereof, which specifically binds to Dickkopf 1 (Dkk-1) polypeptide comprising (a) heavy chain variable region (VH) complementary determining region one (CDR1) comprising the amino acid sequence shown in SEQ ID NO: 30, 49 or 50, a VH CDR2 comprising the amino acid sequence shown in SEQ ID NO: 32 or 51, and VH CDR3 comprising the amino acid sequence shown in SEQ ID NO: 34 or 52; and (b) a light chain variable region (VL) CDR1 comprising the amino acid sequence shown in SEQ ID NO: 22, a VL CDR2 comprising the amino acid sequence shown in SEQ ID NO: 24, and a VL CDR3 comprising the amino acid sequence shown in SEQ ID NO: 26.