Patent ID: 7378420

Claim:
A compound which has formula (1) or is a pharmaceutically acceptable salt or pharmaceutically acceptable conjugate thereof, R 1 is H or alkyl (1-8C), alkenyl (2-8C) or alkynyl (2-8C); each R 3 is independently a substituent selected from the group consisting of ═O, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), acyl, aryl, alkylaryl, halo, CHF 2 , CF 3 , OCF 3 , OCHF 2 , OCOR, CN, NO 2 , NR 2 , OR, SR, COR, COOR, CONR 2 , SOR, SO 2 R, SO 3 R, NRCOR, NROR, NRCOOR, OCONR 2 , SONR 2 , SO 2 NR 2 , OOCR, NRSOR and NRSO 2 R, wherein R is H or alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl, wherein two R on the same nitrogen may form a 5-7 membered ring, and wherein two substituents on adjacent carbons may form a 5-7 membered ring; wherein each R 4 is independently H or alkyl (1-4C); m is 0-3; n is 0-2; wherein each phenyl may independently be substituted by one or more substituents selected from the group consisting of alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), acyl, aryl, alkylaryl, halo, CHF 2 , CF 3 , OCF 3 , OCHF 2 , OCOR, CN, NO 2 , NR 2 , OR, SR, COR, COOR, CONR 2 , SOR, SO 2 R, SO 3 R, NRCOR, NROR, NRCOOR, OCONR 2 , SONR 2 , SO 2 NR 2 , OOCR, NRSOR and NRSO 2 R, wherein R is H or alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl, wherein two R on the same nitrogen may form a 5-7 membered ring, and wherein two substituents on adjacent carbons may form a 5-7 membered ring, and wherein any alkyl, alkenyl, alkynyl or aryl set forth above may further be substituted by ═O, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), acyl, aryl, alkylaryl, halo, CHF 2 , CF 3 , OCF 3 , OCHF 2 , OCOR, CN, NO 2 , NR 2 , OR, SR, COR, COOR, CONR 2 , SOR, SO 2 R, SO 3 R, NRCOR, NROR, NRCOOR, OCONR 2 , SONR 2 , SO 2 NR 2 , OOCR, NRSOR and NRSO 2 R, wherein R is H or alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl, wherein two R on the same nitrogen may form a 5-7 membered ring, and wherein two substituents on adjacent carbons may form a 5-7 membered ring, with the proviso that if all R 4 are H, and m is 0 or 1 and at least one phenyl must be substituted.