Patent ID: 7279299

Claim:
A method for screening a molecule for the ability to interact with a dual specificity phosphatase-10 (DSP-10) polypeptide, comprising the steps of: (a) contacting a candidate molecule with a polypeptide that comprises (i) the amino acid sequence set forth in SEQ ID NO:2; or (ii) an amino acid sequence encoded by a polynucleotide comprising a nucleotide sequence at least 90% identical to SEQ ID NO:1, wherein the polypeptide is capable of dephosphorylating phosphorylated DSP-10 substrate, and wherein the polypeptide comprises the peptide sequence LLIHCQAGVSRSATIV (SEQ ID NO:3), under conditions and for a time sufficient to permit the candidate molecule and polypeptide to interact; and (b) detecting the presence or absence of binding of the candidate molecule to the polypeptide, and therefrom determining whether the candidate molecule interacts with the DSP-10 polypeptide.