Patent ID: 7718601

Claim:
A hybrid compound for the diagnosis or therapy of cells over-expressing the receptor Gb3 having the following formula STxB-Z(n)-Cys-Y-T wherein -STxB is the Shiga Toxin B subunit, -Z(n) wherein n is 0 or 1 and when n is 1, Z is an amino acid residue devoid of a sulfhydryl group, or is a polypeptide, -Cys is the amino acid residue for Cysteine -T is a molecule selected from the group consisting of: i) agents for in vivo diagnosis, ii) cytotoxic agents, ii) prodrugs and iv) enzymes for the conversion of a prodrug to a drug, -Y is an enzyme cleavable linker between T and Cys, said linker being cleavable for the release of T after the internalization of the hybrid compound into said cells.