Patent ID: 7132096

Claim:
A method for inhibiting growth of a bacterium which consists essentially of contacting the bacterium with a compound having the structure: (i) wherein each of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of H, F, Cl, Br, I, —OH, —OR 7 , —CN, —COR 7 , —SR 7 , —N(R 7 ) 2 , —NR 7 COR 8 , —NO 2 , —(CH 2 ) p OR 7 , a straight chain or branched, substituted or unsubstituted C 1 –C 10 alkyl, C 2 –C 10 alkenyl, C 2 –C 10 alkynyl, C 3 –C 10 cycloalkyl, C 3 –C 10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, and heteroaryl; (ii) wherein each of R 7 and R 8 is independently selected from the group consisting of H, F, Cl, Br, I, —OH, —CN, —COH, —SH 2 , —NH 2 , —NHCOH, —(CH 2 ) p OH, a straight chain or branched, substituted or unsubstituted C 1 –C 10 alkyl, C 2 –C 10 alkenyl, C 2 –C 10 alkynyl, C 3 –C 10 cycloalkyl, C 3 –C 10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, and heteroaryl; (iii) wherein A is independently selected from the group consisting of —N 2 —, —NH—, —CH═C═CH—, —C≡C—CHOH—, —C≡C—CH 2 —, —CH 2 —CH 2 —O—, —CH 2 —CH 2 —CH 2 —O—, —S—, —S(═O) 2 —, —C(═O)—, —C(═O)—O—, —NH—C(═O)— and —C(═O)—NH—; and (iv) wherein each of Q and p is independently an integer from 1 to 10, or if Q is 1 A is selected from the group consisting of a (C 1 –C 10 )-alkyl chain, —(C 2 –C 10 )-alkenyl chain, —(C 2 –C 10 )-alkylene chain, and —(C 2 –C 10 )-alkynyl chain which is branched or unbranched, substituted or unsubstituted and can optionally be interrupted 1 to 3 times by —O— or —S— or —N—; or a pharmaceutically acceptable salt or ester thereof, which compound is present in a concentration effective to inhibit growth of the bacterium.