Patent ID: 8877783

Claim:
A compound of formula I wherein X is O or NH; R 1 is pyrimidinyl, optionally substituted with 1, 2 or 3 halo, R 2 is H or CH 3 or CF 3 ; R 3 , R 5 , and R 6 are H; R 4 is H, C 1-7 alkyl, optionally substituted with one or more halo, cyano, or hydroxy, C 1-7 alkoxy, optionally substituted with one or more halo, CN, halo, NO 2 , S—C 1-7 alkyl, S(O)—Cl 1-7 alkyl benzyloxy, optionally substituted with one or more E, —C(O)—R a , wherein R a is hydroxy, C 1-7 alkoxy, C 1-7 alkyl, phenoxy or phenyl, 3- to 7-membered heterocyclyl, optionally substituted with one or more A, —C(O)—NR b R c , wherein R b and R c are each independently H, C 1-7 alkyl, optionally substituted with one or more halo, methyl, —(CH 2 ) t -hydroxy, or cyano, —(CH 2 ) t —C 3-7 cycloalkyl, optionally substituted by one or more B, and t is 0, 1, 2, 3, 4, 5 or 6, —(CH 2 ) u —O—C 1-7 alkyl, wherein u is 2, 3, 4, 5 or 6, —CHR i —C(O)OR ii , wherein R i is H, benzyl or C 1-4 alkyl, and R ii is H or C 1-7 alkyl, —S(O) 2 —C 1-7 alkyl, —S(O) 2 —C 3-7 cycloalkyl, —(CH 2 CH 2 O) v R iii , wherein v is from 1 to 3, and R iii is H or C 1-7 alkyl, —(CH 2 ) w -heteroaryl or —(CH 2 ) w -aryl, each optionally substituted by one or more E, and wherein w is 0, 1, 2, 3, or 4, —(CH 2 ) x -heterocyclyl, wherein x is 0, 1, 2, 3 or 4, and wherein heterocyclyl is optionally substituted by one or more oxo, C 1-7 alkyl, C 3-7 cycloalkyl, optionally substituted with one or more B, CN, benzyl, optionally substituted with one or more E, —(CH 2 ) y —C(O)R iv , wherein y is 0, 1, 2, 3 or 4, and R iv is hydroxy,C 1-7 alkyl, or C 1-7 alkoxy, —(CH 2 ) z —C(O)NR v R vi , —(CH 2 ) z NR v R vi —C(O)—C 1-7 alkyl or —(CH 2 ) z NR v R vi —C(O)—O—C 1-7 alkyl, wherein z is 0, 1, 2, 3 or 4, and R v and R vi are independently hydrogen, C 1-7 alkyl, optionally substituted by one or more halo, OH or CN, C 3-7 cycloalkyl, optionally substituted by one or more B, 5- or 6-membered heterocyclyl, optionally substituted by one or more A, or R v and R vi together with the nitrogen to which they are bound form a 5- or 6-membered heterocycloalkyl, optionally substituted by one or more A, or R b and R c together with the nitrogen to which they are bound form a heterocyclyl or heteroaryl moiety, optionally substituted with one or more A, or R b and R c together with the nitrogen to which they are bound form a 7-to 12-membered spirocyclic heterocycle, optionally substituted with one or more A; with the proviso that R b and R c are not simultaneously H, A is hydroxy, oxo, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 hydroxyalkyl, halo, or CN; B is halo, hydroxy, CN, C 1-4 alkyl, benzyloxy, or C 1-4 haloalkyl; and E is halo, CN, NO 2 , hydroxy, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 haloalkyl, C 1-7 hydroxyalkyl, C 1-7 cyanoalkyl, C 1-7 haloalkoxy, or C 3-7 cycloalkyl; or a pharmaceutically acceptable salt thereof.