Patent ID: 7351697

Claim:
A vector for treating tumors by gene therapy, comprising a DNA sequence comprising a) a first sequence encoding T7 RNA polymerase under control of a tissue-specific promoter that is a telomerase catalytic subunit promoter or a cyclin-A promoter; b) at least one therapeutic gene under control of a first T7 promoter, wherein the therapeutic gene encodes a protein selected from the group consisting of: cytosine deaminase (CD), herpes simplex-virus thymidine kinase (HSV-TK), DNA-binding domain (DBD) of poly(ADP-ribose) polymerase (PARP), cytotoxic protease 2A and 3C; or a fusion protein comprising at least two proteins selected from the group of proteins; and c) a second sequence encoding T7 RNA polymerase under control of second T7 promoter.