Patent ID: 8476270

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: L 1 is —NR 8 —, —O—, —S—, —N(R 8 )C(O)—, —S(O) 2 —, —S(O)—, or a covalent bond; R 1 is H, alkyl of 1-8 carbon atoms, alkenyl of 2-8 carbon atoms, or alkynyl of 2-8 carbon atoms, all of which are optionally substituted by alkyl of 1-6 carbon atoms, alkoxy of 1-4 carbon atoms, carbocyclyl of 3-8 carbon atoms, or halo; Z is H, halogen, or alkyl, in which alkyl is optionally substituted by halo; X 1 is alkylene of 1-6 carbon atoms optionally substituted by alkyl of 1-4 carbon atoms, —O—, —C(O)—, —S(O)—, —S(O) 2 —, or a covalent bond; D is carbocyclyl, heterocyclyl, aryl, or heteroaryl; L 2 is alkylene of 1-6 carbon atoms optionally substituted by alkyl of 1-4 carbon atoms , or a covalent bond; R 2 is —NR 6 R 7 ; m is 1 or 2; R 3 is alkyl of 1-6 carbon atoms or halogen; n is 0, 1, 2, 3, 4 or 5; R 4 and R 5 are each independently H or alkyl of 1-6 carbon atoms, or R 4 and R 5 , taken together with the carbon to which they are attached, form —C(═O); R 6 and R 7 are each independently H or alkyl of 1-6 carbon atoms, or R 6 and R 7 , taken together with the nitrogen to which they are both attached, form a 3 to 8 membered heterocycle; and R 8 is H or alkyl of 1-6 carbon atoms.