Patent ID: 7304061

Claim:
A compound of general formula I: or a pharmaceutically acceptable salt thereof, wherein: A 1 is N; A 2 is CR 11 ; T is selected from —C(R 7 ) 2 —, —C(O)—, —C(O)C(O)—, —C(O)NR 7 —, —C(O)NR 7 NR 7 —, —CO 2 —, —OC(O)—, —NR 7 CO 2 —, —O—, —NR 7 C(O)NR 7 —, —OC(O)NR 7 —, —NR 7 NR 7 —, —NR 7 C(O)—, —S—, —SO—, —SO 2 —, —NR 7 —, —SO 2 NR 7 —, —NR 7 SO 2 —, or —NR 7 SO 2 NR 7 —; m is selected from zero or one; R 1 is selected from: (a) hydrogen, CN, halogen, R, N(R 7 ) 2 , OR, or OH, wherein m is zero; or (b) hydrogen or R, wherein m is one; X is selected from —C(O)—, —C(O)NR 7 —, —NR 7 C(O)—, —NR 7 SO 2 —, —SO 2 NR 7 —, —S(O)—, or —SO 2 —; R 2 is selected from —(CH 2 ) y R 5 , —(CH 2 ) y CH(R 5 ) 2 , —(CH 2 ) y CH(R 8 )(R 5 ), —(CH 2 ) y CH(R 8 )CH(R 5 ) 2 , —N(R 4 ) 2 , —NR 4 (CH 2 ) y N(R 4 ) 2 , —ON(R 7 ) 2 , or —NR 7 OR 6 ; y is 0-6; R 3 is selected from —R, —OR 6 , —S(O)R 6 , or —ON(R 7 ) 2 ; R 6 is selected from hydrogen or —R; each R is independently selected from an optionally substituted group selected from C 1-6 aliphatic; 3-7 membered saturated, partially saturated, or aromatic monocyclic ring having zero to three heteroatorns independently selected from nitrogen, sulfur, or oxygen; or an 8-10 membered saturated, partially saturated, or aromatic bicyclic ring having zero to four hetero atoms independently selected from nitrogen, sulfur, or oxygen; each R 4 is independently selected from —R, —R 7 , —COR 7 , —CO 2 R, —CON(R 7 ) 2 , —SO 2 R 7 , —(CH 2 ) y R 5 , or —(CH 2 ) y CH(R 5 ) 2 ; each R 5 is independcntly selected from —R, —OR, —CO 2 R, —(CH 2 ) y N(R 7 ) 2 , —N(R 7 ) 2 , —OR 7 , —SR 7 , —NR 7 C(O)R 7 , —NR 7 CON(R 7 ) 2 , —C(O)N(R 7 ) 2 , —SO 2 R 7 , —NR 7 SO 2 R 7 , —C(O)R 7 , —CN, or —SO 2 N(R 7 ) 2 ; each R 7 is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or two R 7 groups bound to the same nitrogen are taken together with the nitrogen to form a 3-7 membered heterocyclic ring having 0-2 heteroatoms in addition to the nitrogen, independently selected from nitrogen, oxygen, or sulfur; R 8 is selected from —R, —(CH 2 ) w OR 7 , —(CH 2 ) w N(R 4 ) 2 , or —(CH 2 ) w SR 7 ; each w is independently selected from 0-4; R 9 is selected from hydrogen, an optionally substituted C 1-6 aliphatic group, C(O)R 7 , C(O)OR 7 , or SO 2 R 7 ; R 11 is selected from R 7 , halogen, CN, NO 2 , OR 7 , SR 7 , N(R 7 ) 2 , C(O)R 7 , or CO 2 R 7 ; and each of R 12 and R 13 is hydrogen.