Patent ID: 7557120

Claim:
A compound of the formula II wherein: A is selected from the group consisting of C and N; D is independently selected from the group consisting of C, N, O, —SO— and —SO 2 —, E is N; Y is selected from the group consisting of —CH 2 — and —O—; R 1 is selected from the group consisting of: (a) C 1-6 alkyl, (b) C 1-6 alkyl substituted with hydroxy, and (c) C 1-6 alkyl substituted with 1-6 fluoro; if D is C, R 2 is selected from the group consisting of: (a) hydrogen, (b) C 1-3 alkyl, optionally substituted with 1-3 fluoro, (c) —O—C 1-3 alkyl, optionally substituted with 1-3 fluoro, (d) hydroxy, (e) chloro, (f) fluoro, (g) bromo, (h) phenyl, and (i) =O; if D is N, R 2 is selected from the group consisting of: (a) hydrogen, (b) C 1-3 alkyl, optionally substituted with 1-3 fluoro, (c) —O—C 1-3 alkyl, optionally substituted with 1-3 fluoro, (d) phenyl, (e) O, and (f) nothing; if D is O, SO, or SO 2 , R 2 is nothing; R 3 is selected from the group consisting of: (a) hydrogen, (b) C 1-3 alkyl, optionally substituted with 1-3 fluoro, (c) —O—C 1-3 alkyl, optionally substituted with 1-3 fluoro, (d) phenyl, (e) O, and (f) nothing; if E is O, SO, or SO 2 , R 3 is nothing; R 4 is hydrogen; R 5 is selected from the group consisting of: (a) C 1-6 alkyl substituted with 1-6 fluoro, (b) —O—C 1-6 alkyl substituted with 1-6 fluoro, (c) chloro, (d) bromo, and (e) phenyl; R 6 is hydrogen; R 15 is selected from the group consisting of hydrogen and methyl; R 16 is selected from the group consisting of: (a) hydrogen, (b) C 1-3 alkyl, which is unsubstituted or substituted with 1-6 fluoro, (c) —O—C 1-3 alkyl, (d) fluoro, and (e) hydroxy; R 17 is hydrogen; R 18 is selected from the group consisting of: (a) hydrogen, (b) methyl, and (c) methoxy; and 1 is 1; or a pharmaceutically acceptable salt or individual diastereomer thereof.