Patent ID: 6949545

Claim:
A compound having a structure according to Formula (I): wherein: (A) R 1 is —OH; (B) R 2 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl and heteroarylalkyl; (C) R 3 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, arylalkyl and heteroarylalkyl; (D) E is selected from a covalent bond, C 1 -C 4 alkyl, —C(═O)—, —C(═O)O—, —C(═O)N(R 4 )—, —SO 2 — and —C(═S)N(R 4 )—, where R 4 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; or R 4 and X join to form a ring as described in (E) (2); (E) (1) X is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl; or (2) X and R 4 join to form a substituted or unsubstituted, monocyclic heterocycloalkyl having from 3 to 8 ring atoms of which 1 to 3 are heteroatoms; (F) G is —C(R 5 )═C(R 5′ )—, where R 5 and R 5′ each is hydrogen; (G) G′ is selected from —S—, —O—, —N(R 6 )—, —C(R 6 )═C(R 6′ )—, —N═C(R 6 )—, and —N═N—, where R 6 ′ and R 6′ each is independently selected from hydrogen, alkyl, alkenly, alkynyl, heteroalkyl, heteroaryl, cycloalkyl and heterocycloalkyl; (H) M is selected from —CH— and —N—; and (I) Z is —(CR 7 R 7′ ) a —L—R 8 , where: (1) a is from 0 to about 4; (2) each R 7 and R 7′ is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroalkyl, heteroaryl, cycloalkyl, heterocycloalkyl, halogen, haloalkyl, hydroxy and alkoxy; (3) L is selected from a covalent bond, —O—, —SO b —, —C(═O)—, —C(═O)N(R 9 )—, —N(R 9 )— and —N(R 9 )C(═O)—; where b is from 0 to 2 and R 9 is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalkyl, heteroaryl, cycloalkyl, heterocycloalkyl and haloalkyl; or R 7 and R 9 , together with the atoms to which they are bonded, join to form an optionally substituted heterocyclic ring containing from 5 to 8 atoms of which 1 to 3 are heteroatoms; and (4) R 8 is selected from hydrogen, alkyl, alkenyl, alkynyl, halogen, heteroalkyl, haloalkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl; or R 8 and R 9 , together with the atoms to which they are bonded, join to form an optionally substituted heterocyclic ring containing from 5 to 8 atoms of which 1 to 3 are heteroatoms; or an optical isomer, diastereomer or enantiomer for Formula (I), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.