Patent ID: 8143253

Claim:
A compound of formula I in free or salt form, wherein R1 is aryl or heterocyclyl, R1 being optionally substituted by one or more groups R3 independently selected from: hydroxyl, carbonyl, aminocarbonyl, C 1 -C 7 alkylaminocarbonyl, amino, C 1 -C 7 alkylamino, C 1 -C 7 alkylthio, sulfonylamino, carbonylamino, C 1 -C 7 alkylcarbonylamino, halo, carboxy, C 1 -C 7 alkoxy, benzyloxy, C 1 -C 7 alkyloxycarbonyl, aminosulfonyl, C 1 -C 7 alkyl, cyano, sulfonyl, sulfanyl, sulfoxide, aryl, heterocyclyl, carbonyloxy, amino C 1 -C 7 alkyl, C 1 -C 7 alkylamino-C 1 -C 7 alkyl, aryl-C 1 -C 7 -alkyl and heterocyclyl-C 1 -C 7 -alkyl, C 4 -C 15 -cycloalkenyl and C 2 -C 8 -cycloalkynyl; and when R3 includes two groups, such R3 groups may be joined together to form a ring which is fused to R1; wherein R3 is optionally substituted by one or more groups selected from hydroxyl, C 1 -C 7 alkyl, aryl, amino, C 1 -C 7 alkylamino, heterocyclyl, cyano, halo, sulfonyl, sulfanyl, sulfoxide, di(C 1 -C 7 ) alkylamino, hydroxyl-C 1 -C 7 alkyl, alkoxy, di-C 1 -C 7 alkylamino-C 1 -C 7 alkyl; R2 is aryl, heteroaryl, heteroaryl-aryl, heteroaryl-heterocyclyl, aryl-heterocyclyl, biaryl, heterocyclyl-heterocyclyl; R2 being optionally substituted by one or more groups R4 independently selected from aryl, heteroaryl, heterocycloalkyl, C 1 -C 7 alkyl, C 3 -C 10 -cycloalkyl, aminocarbonyl, C 1 -C 7 alkylaminocarbonyl, halo, C 1 -C 7 alkoxy, C 1 -C 7 alkylthio, hydroxyl, C 1 -C 7 alkylcarbonyl, carboxy, carbonyl, cyano, sulfonamide and from C 4 -C 15 -cycloalkenyl; and when R4 includes two groups, such R4 groups may be joined together to form a ring which is fused to R2; wherein R4 is optionally substituted by one or more groups selected from hydroxyl, C 1 -C 7 alkyl, aryl, amino, C 1 -C 7 alkylamino, heterocyclyl, cyano, halo, sulfonyl, sulfanyl, sulfoxide; R5 is H or NH 2 .