Patent ID: 7528276

Claim:
A process for preparing intermediate compounds of formula (II) for preparing ligands of PPAR α which comprises reacting 4-bromophethylamine of formula (I) with Grignard reagents to form compounds of formula (V), substituting lithium metal for halogen of said compounds of formula (V), reacting the resulted compounds with sulfur to form lithium-thiol intermediate compounds and reacting the resulted compounds with compounds of formula (VIII) continuously without separation and purification, wherein, R 1 and R 2 represent methyl group or a hydrogen atom, R 3 of Grignard reagents (R 3 MgX 3 ) and R 4 of alkyl lithium reagents (R 4 Li) represent —(C 1 -C 4 ) alkyl group, X 1 represents a bromine atom or iodine atom, X 2 and X 3 represent a chlorine atom, bromine atom or iodine atom.