Patent ID: 8039443

Claim:
A monotherapy regimen for reducing angiogenesis and neovascularization in a tumor comprising the step of administering a therapeutically effective amount of an aptamer having the following structure: Aptamer denotes 5′-dCdCdCdAdGdGdCdTdAdCmG (SEQ ID NO: 69)-PEG-dCdGdTdAmGdAmGdCdAmUmCmA (SEQ ID NO: 40)-PEG-dTdGdAdTmCdCdTmGmGmG-3T-3′ (SEQ ID NO: 70); wherein “dN” is a deoxy nucleotide, “mN” is a 2′-OMe nucleotide, “PEG” is a polyethylene glycol spacer and “3T” is an inverted deoxy thymidine cap.