Patent ID: 8623871

Claim:
A compound represented by formula (VI): or a pharmaceutically acceptable salt thereof, wherein: Y′ 1 is an optionally substituted C 1 -C 6 alkyl or optionally substituted cycloalkyl, wherein the optional substituents are 1, 2, or 3 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, haloalkyl, —C(O)NR 1 R 2 ,—NR 4 C(O)R 5 , halo, —OR 4 ,cyano, nitro, haloalkoxy, —C(O)R 4 , —NR 1 R 2 ,—SR 4 , —C(O)OR 4 , —OC(O)R 4 , —NR 4 C(O)NR 1 R 2 , —OC(O)NR 1 R 2 , —NR 4 C(O)OR 5 , —S(O) p R 4 ,and —S(O) p NR 1 R 2 ; X 3 and X 4 are each, independently, CH or CZ 1 ,; L′ is —NHCH 2 —, —CH 2 NH—, —NHC(O)—, C(S)—, or —NHC(S)—; Z 1 and Z 2 are each, independently, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, a haloalkyl, —C(O)NR 1 R 2 , —NR 4 C(O)R 5 , halo, —OR 4 , cyano, nitro, haloalkoxy, —C(O)R 4 , —NR 1 R 2 , —SR 4 , —C(O)OR 4 , —OC(O)R 4 , —NR 4 C(O)NR 1 R 2 , —OC(O)NR 1 R 2 , —NR 4 C(O)OR 5 , —S(O) p R 4 , or —S(O) p NR 1 R 2 ; Z 3 is a substituted monocyclic aryl or an optionally substituted monocyclic heteroaryl with no more than two heteroatoms, wherein the substituents are selected from the group consisting of an optionally substituted C 2 -C 6 alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, a haloalkyl, —C(O)NR 1 R 2 , —NR 4 C(O)R 5 , halo, —OR 4 , cyano, nitro, haloalkoxy, —C(O)R 4 , —NR 1 R 2 , —SR 4 , —C(O)OR 4 , —OC(O)R 4 , —NR 4 C(O)NR 1 R 2 , —OC(O)NR 1 R 2 , —NR 4 C(O)OR 5 , —S(O) p R 4 , and —S(O) p NR 1 R 2 ; R, for each occurrence, is independently —H alkyl, —C(O)R 7 , or —C(O)OR 7 ; R 1 and R 2 , for each occurrence are, independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; or R 1 and R 2 are taken together with the nitrogen to which they are attached to form optionally substituted heterocyclyl or optionally substituted heteroaryl; R 4 , R 5 , R 7 , and R 8 , for each occurrence are, independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; R 6 , for each occurrence, is —H or alkyl; n is 0, 1, or 2; and p is 0, 1, or 2.