Patent ID: 7550467

Claim:
A compound, having the general structure represented by structural Formula 1: or a pharmaceutically acceptable salt thereof wherein: Ar is (R 19 ) q -substituted phenyl or (R 19 ) q -substituted pyridyl; R 3 is independently selected at each occurrence thereof from the group consisting of: H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, alkylaryl, heteroaralkyl, heteroarylalkenyl, heteroarylalkynyl, alkylheteroaryl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, keto, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, heterocyclyl, —C(═N—CN)—NH 2 , —C(═NH)—NH 2 , —C(═NH)—NH(alkyl), -alkyl-NR 17 R 18 , —C(═O)NR 17 R 18 , —NR 17 R 18 , —NHC(═O)R 17 , —NHC(═O)OR 17 , —NHC(═O)NR 17 R 18 , —NHS(O) 2 R 17 , —NHS(O) 2 NR 17 R 18 , —S(O)R 17 , —S(O) 2 R 17 and S(O) 2 NR 17 R 18 ; or two R 3 moieties on adjacent carbons can be linked together to form a 4 to 6 membered cycloalkyl or 4 to 6 membered heterocyclyl group, with the proviso that there are no adjacent oxygen or sulfur atoms present in the heterocyclyl group, wherein the cycloalkyl and heterocyclyl groups are fused to the ring carbons to which R 3 is attached; R 12 is independently selected at each occurrence thereof from the group consisting of: H, alkyl, cycloalkyl, alkoxyalkyl, hydroxyalkyl and cycloalkoxyalkyl; R 13 is H, alkyl, aryl, heteroaryl, alkoxyalkyl, hydroxyalkyl, acyl, alkoxycarbonyl, cycloalkoxyalkyl, carbamoyl, arylsulfonyl, alkylsulfonyl or —CN; R 17 and R 18 are each independently selected at each occurrence thereof and are each independently H, alkyl, cycloalkyl, aryl, heteroalkyl and heteroarylalkyl; R 19 is independently selected at each occurrence thereof from the group consisting of: H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, alkylaryl, heteroaralkyl, heteroarylalkenyl, heteroarylalkynyl, alkylheteroaryl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, heterocyclyl, —C(═N—CN)—NH 2 , —C(═NH)—NH 2 , —C(═NH)—NH(alkyl), —NR 17 R 18 , -alkyl-NR 17 R 18 , —C(═O)NR 17 R 18 , —NHC(═O)R 17 , —NHC(═O)OR 17 , —NHC(═O)NR 17 R 18 , —NHS(O) 2 R 17 , —NHS(O) 2 NR 17 R 18 , —S(O) 2 NR 17 R 18 , and —S(O) 2 NR 17 R 18 ; r is 1, 2, 3 or 4; q is 1, 2 or 3; and t is 1 or 2.