Patent ID: 7001905

Claim:
A compound of formula I: or the pharmaceutically acceptable salts thereof; wherein R 1 is hydrogen, C 1-8 alkyl, C 1-8 alkoxy, halo, C 1-2 haloalkyl, or CN; R 3 and R 4 are each independently hydrogen, halo, C 1-2 haloalkyl, C 1-8 alkyl, C 1-8 alkoxy, nitro, CN, or (O or NH) k —(CH 2 ) j —R 9 , where R 9 is hydrogen, hydroxy, CO 2 H or NR 10 R 11 ; j is 0 to 4; k is 0 or 1; R 10 and R 11 are each independently hydrogen or C 1-8 alkyl, or together with the nitrogen to which they are attached form a 3- to 10-member cyclic ring optionally containing one, two, or three additional heteroatoms selected from the group consisting of O, S, NH, and N—C 1-8 alkyl; A is hydroxy, C 1-6 alkoxy, or NR 6 OR 7 ; R 6 is hydrogen, C 1-8 alkyl, (CO)—C 1-8 alkyl, phenyl, naphthyl, phenyl(C 1-8 alkyl), or C 3-10 cycloalkyl; R 7 is hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-10 cycloalkyl or C 3-10 cycloalkyl optionally containing a heteroatom selected from the group consisting of O, S, and NR 9 ; X is NR 13 R 12 , or NR 14 ; R 12 and R 13 are each independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 4-6 cycloalkyl, [(CH 2 ) n Y(CH 2 ) m ] q CH 3 , phenyl, naphthyl, (C 1-6 alkyl)phenyl, —[(CH 2 ) n Y(CH 2 ) m ] q phenyl, C 2-6 heteroaryl, (C 1-6 alkyl)C 2-6 heterocyclic radical, or [(CH 2 ) n Y(CH 2 ) m ] q C 2-6 heterocyclic radical; Y is NH or O; R 14 taken with N is a 5- to 7-membered heterocyclic radical with between 0 and 3 additional heteroatoms or heteroatom combinations in the ring selected from the group consisting of O, S, SO, SO 2 , NH, and NMe; 0 ≦n, m≦ 6, n+m≦ 8, 1 ≦q≦ 5; and wherein the above alkyl, alkenyl, alkynyl, heterocyclic radical, aryl, and cycloalkyl groups can be optionally substituted with between 1 and 4 substituents independently selected from the group consisting of hydroxy, C 1-4 alkyl, fluoro, chloro, iodo, bromo, amino, and C 1-4 alkoxy, and NR a R b ; wherein R a and R b are each independently selected from the group consisting of hydrogen and C 1-6 alkyl.