Patent ID: 8202856

Claim:
A compound according to formula I: wherein X is O or S; R 1 denotes H, Hal, CF 3 , OCF 3 , CN, or NO 2 ; R 2 is H, A or Hal; R a is H, A, Ar, or Het; R b is A, Ar, Het, OA, NHA, or NA 2 , Ar-alkyl, or Het-alkyl; Hal is F, Cl, Br or I; A is a branched or linear alkyl having 1 to 12 C-atoms, wherein one or more may be replaced by Hal, OR 3 , CN, CO 2 R 3 , cycloalkyl having 3 to 7 ring carbon atoms, or N(R 3 ) 2 and wherein one or more non-adjacent CH 2 -groups may be replaced by O, NR 3 or S and/or by —CO—, —NR 3 CO—, —CONR 3 —, NR 3 CO 2 —, —NR 3 CONR 3 —, —CH═CH—, —C≡C—groups, or or denotes cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms; q is 1, 2, 3, or 4; Ar denotes a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by a substituent selected from R 4 and/or R 5 ; Ar-alkyl denotes an aryl group linked to the rest of the molecule through a C 1 -C 12 alkylene chain; Het denotes a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by a substituent selected from R 4 and/or R 5 ; and wherein one or more CH 2 groups may be replaced by —CO—; Het-alkyl denotes a group Het linked to the rest of the molecule through a C 1 -C 12 alkylene chain; R 4 and R 5 are each independently selected from A, Hal, hydroxy, alkoxy, carboxy, carboxy-alkyl, perfluoro-alkyl, perfluoro-alkoxy, acyl, alkylsulfonyl, sulfonyl, —SO 2 (R 3 ) 2 , cyano, nitro, amino, amido, alkyl optionally substituted by a carboxy, —N(R 3 ) 2 , —CO(NR 3 ) 2 , —OR 3 , (NR 3 )COR 3 , —CO 2 R 3 , —COR 3 , or Ar-alkyl or Het-alkyl both optionally substituted by A, Hal, an acyl, alkylsulfonyl, carboxy, —N(R 3 ) 2 , —CON(R 3 ) 2 , —OR 3 , (NR 3 )COR 3 , —CO 2 R 3 , —COR 3 , —SO 2 N(R 3 ) 2 , —SO 2 alkyl, NR 3 SO 2 alkyl, NR 3 SO 2 alkyl, or C 1 - C 6 alkyl; R 3 is H or A; or a pharmaceutically acceptable tautomer, salt or stereoisomer thereof, including mixtures thereof.