Patent ID: 7935685

Claim:
A process for making an inclusion complex of a poorly water soluble non-steroidal anti-inflammatory drug and a cyclodextrin, said process comprising: (a) mixing said drug and said cyclodextrin, in the form of finely divided powders, in the presence of a small amount of water or an aqueous solution of one or more components selected from the group consisting of an alcohol, an acid, and a base, to obtain a mixture consisting essentially of said drug, said cyclodextrin, and said water or said aqueous solution; (b) treating said mixture in a microwave oven, at radiation power of from 100 to 800 W for a time of 1 and 60 minutes, to obtain a treated product; and (c) drying said treated product under vacuum at room temperature or with heating at a temperature below 50° C.; wherein: the mixture contains water or the aqueous solution in an amount of 20 to 80% by weight; and the dried product is in amorphous form.