Patent ID: 8765148

Claim:
Pharmaceutical composition in an aqueous mixture form comprising a peptide with the amino acid sequence KLKL 5 KLK (SEQ ID NO:1) and an oligodeoxynucleotide with the nucleic acid sequence (dIdC) 13 (SEQ ID NO:2) wherein the peptide and the oligodeoxynucleotide are present as stable complexes, characterized in that the peptide is present at a concentration of at least 100 nmol/mL and the oligodeoxynucleotide is present at a concentration of at least 4 nmol/mL, molar ratio of the peptide to the oligodeoxynucleotide is between 20:1 and 50:1, mean particle size of the stable complexes comprising the peptide and the oligodeoxynucleotide is less than 1 μm, sodium ion concentration is from 0 to 25 mM, the composition optionally comprises Ca2+ ions, phosphate ions, citrate ions, or acetate ions at a concentration of less than 1 mM each, the composition comprises 3 to 10 mM of Tris (Tris(hydroxymethyl)aminomethane) buffer with a pH of 6 to 7.2, 3 to 20 mM of Histidine buffer with a pH of 6 to 7, or 5 to 10 mM of ammonium bicarbonate buffer with a pH of 7 to 8, optionally, the composition has a viscosity less than 15 cP, and optionally, the composition is sterile.