Patent ID: 8246968

Claim:
A stealth nanoparticle having a diameter of 80 nm to 200 nm, comprising a diblock copolymer of poly (ethylene glycol) and poly (lactic) acid (PLA) or poly (ethylene glycol) and poly (lactic acid-co-glycolic) acid (PLGA); a prostate specific membrane antigen ligand conjugate comprising by: wherein R 1 and R 3 are alkyl groups, R 2 is an ester or amide linkage, x+y=20 to 1720, and z=25 to 455; and a therapeutic agent wherein the nanoparticle comprises an amount of the prostate specific membrane antigen ligand conjugate that is effective for the treatment of solid tumors expressing prostate specific membrane antigen in the tumor neovasculature when the nanoparticle is intravenously administered to the patient in need thereof.