Patent ID: 8614201

Claim:
A compound of Formula (I), pharmaceutically acceptable salt of a compound of Formula (I), or a pharmaceutically acceptable prodrug of a compound of Formula (I), wherein, Ar 1 is: iii) phenyl substituted with 0, 1, 2 or 3 substituents R a ; or iv) a 5- or 6-membered monocyclic aromatic heterocycle ring optionally substituted with one or two substituents R a ; where each R a is independently halo, —C 1-4 alkyl, —OC 1-4 alkyl, —CN, —CF 3 , —OCF 3 , —NO 2 , —C(O)C 1-4 alkyl or —CO 2 H; Ar 2 is: i) phenyl substituted with 0, 1, 2 or 3 substituents R b ; where each R b is independently halo, —C 1-4 alkyl, —C(O)NR c R d , —OC 1-4 alkyl, —OC 1-4 alkylCF 3 , —CN, —CF 3 , —OCF 2 H, —NO 2 , —NR c R d , —S(O) 0-2 C 1-4 alkyl, —C(O)C 1-4 alkyl, —S(O)(O)NH 2 , —(CH 2 ) 0-2 -morpholinyl, piperidin-1-yl or piperazinyl, said piperazinyl optionally substituted with a methyl; ii) pyridyl substituted with 0, 1 or 2 substituents R e , where each R e is independently selected from halo, —C 1-4 alkyl, —OC 1-4 alkyl, —CF 3 , —NR c R d or 4-morpholinyl; or iii) a bicyclic 9- or 10-membered aromatic heterocycle optionally substituted with 1 substituent R f ; where R f is —C 1-4 alkyl; R c and R d are each independently selected from H or —C 1-4 alkyl; W is —CR n H— or —CF 2 —; X is —CR n H—; or W and X may each be a CH group linked together by a double bond; R n is H or —OH; or two adjacent R n moieties taken together form —CH 2 —; R 1 and R 2 are each independently H or —C 1-4 alkyl; each Y is independently CH or N; Z is CR g ; R g is i) H, —C 1-4 alkyl, —CF 3 , —OR z , —N(CH 3 ) 2 or —NR h R i ; where R h is selected from H, 2-hydroxy-propyl, 2-hydroxy-2-methyl-propyl, —C 1-4 alkyl-N(CH 3 ) 2 , —C 1-4 alkyl-pyridyl, —C 1-4 alkyl-phenyl, 1-pyridinyl-ethyl, 1-methyl-pyrrolidin-3-ylmethyl or —C 1-4 alkyl-piperidinyl, said piperidinyl optionally substituted with —C 1-4 alkyl; where R z is —C 1-4 alkyl, —C 1-4 alkylCF 3 or —C 1-4 alkyl-heterocycloalkyl; ii) 1-pyrrolidinyl optionally substituted with —C 1-4 alkyl or —NR k R 1 ; iii) piperazinyl optionally substituted with —C 2-5 alkyl, —OC 1-4 alkyl, —C 1-4 -alkyl-pyridyl, —C 0-4 alkyl-1-methyl-piperidin-4-yl, —C 0-4 alkylNR k R i or —C 0-4 -alkyl-phenyl, said phenyl optionally substituted with one or two substituents selected from the group consisting of Cl, Br, I, —OCF 3 , and —C 1-4 alkyl or said one substituent is F bound at the 2-position; iv) phenyl optionally substituted with —CF 3 ; or vii) pyridyl; viii) 1-piperidinyl; R k is H, —C 1-4 alkyl or —C(O) 1-2 C 1-4 alkyl; and R i is H or CH 3 ; with the proviso that when Ar 1 is 4-fluoro-phenyl; Ar 2 is 4-trifluoromethyl-phenyl; R 1 and R 2 are each H; W and X are each —CH 2 —; and the two Y's adjacent to Z are N with the third being C; then R g cannot be [4-(2-fluoro-phenyl)-piperazin-1-yl].