Patent ID: 7566444

Claim:
A compound of formula wherein W 5 and X 5 are —S—; Y 5 is selected from the group consisting of —(CH 2 ) a —CONH—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—Bm, —(CH 2 ) a —NHCO—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO—Bm, —(CH 2 ) a —N(R 3 )—(CH 2 ) b —CONH—Bm, (CH 2 ) a —N(R 3 )—(CH 2 ) c —NHCO—Bm, —(CH 2 ) a N(R 3 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—Bm, —(CH 2 ) a —N(R 3 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—(CH 2 ) a —CONH—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—(CH 2 ) a —NHCO—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—CH 2 —(CH 2 OCH 2 ) d —CONH—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—CH 2 —(CH 2 OCH 2 ) d —NHCO—Bm, —(CH 2 ) a NR 3 R 4 , and —CH 2 (CH 2 OCH 2 ) b —CH 2 NR 3 R 4 ; Z 5 is selected from the group consisting of —(CH 2 ) a —CONH—Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—Dm, —(CH 2 ) a —NHCO—Dm, —CH 2 (CH 2 OCH 2 ) b —CH 2 —NHCO—Dm, —(CH 2 ) a —N(R 3 )—(CH 2 ) b —CONH—Dm, (CH 2 ) a —N(R 3 )—(CH 2 ) c —NHCO—Dm, —(CH 2 ) a —N(R 3 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—Dm, —(CH 2 ) a —N(R 3 )—CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO—Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—(CH 2 ) a —CONH—Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—(CH 2 ) a —NHCO—Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—CH 2 —(CH 2 OCH 2 ) d —CONH—Dm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —N(R 3 )—CH 2 —(CH 2 OCH 2 ) d —NHCO—Dm, —(CH 2 ) a —NR 3 R 4 , and —CH 2 (CH 2 OCH 2 ) b —CH 2 NR 3 R 4 ; A 3 is a single or a double bond; B 3 , C 3 , and D 3 are independently selected from the group consisting of —O—, —S—, —Se—, —P—, —CR 1 R 2 , —CR 1 , alkyl, NR 3 , and —C═O; A 3 , B 3 , C 3 , and D 3 may together form a 6- to 12-membered carbocyclic ring or a 6- to 12-membered heterocyclic ring optionally containing one or more oxygen, nitrogen, or sulfur atom; a 5 varies from 0 to 5; R 1 to R 4 , and R 58 to R 66 are independently selected from the group consisting of hydrogen, C 1 -C 10 alkyl, C 5 -C 20 aryl, C 1 -C 10 alkoxyl, C 1 -C 10 polyalkoxyalkyl, C 1 -C 20 polyhydroxyalkyl, C 5 -C 20 polyhydroxyaryl, C 1 -C 10 aminoalkyl, cyano, nitro, halogen, saccharide, peptide, —CH 2 (CH 2 OCH 2 ) b —CH 2 —OH, —(CH 2 ) a —CO 2 H, —(CH 2 ) a —CONH—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —CONH—Bm, —(CH 2 ) a —NHCO—Bm, —CH 2 —(CH 2 OCH 2 ) b —CH 2 —NHCO—Bm, —(CH 2 ) a —OH and —CH 2 —(CH 2 OCH 2 ) b —CO 2 H; Bm and Dm are independently selected from the group consisting of bioactive peptide, protein, cell, antibody, antibody fragment, saccharide, glycopeptide, peptidomimetic, drug, drug mimic, hormone, metal chelating agent, radioactive or nonradioactive metal complex, and echogenic agent; a and c independently vary from 1 to 20; b and d independently vary from 1 to 100.