Patent ID: 7772363

Claim:
An isolated polypeptide selected from the group consisting of: VENKC2NKE1MRNAYWE1IALLPNLNNQQKRXFIRSLYDDPC2 (SEQ ID NO: 34) or a four residue N-terminal truncated variant of SEQ ID NO: 34 wherein C2 is extended cysteine and a disulfide bond is between the C2 residues that stabilizes the peptide and increases its binding affinity; wherein X is alpha amino isobutyric acid (Aib) or its analog that increases its binding affinity; wherein E1 is selected from an O-allyl glutamic acid or an O-allyl glutamic acid analog thereof and a covalent bridge extends between two E1 residues; and wherein the polypeptide specifically binds to human epidermal growth factor receptor 2 (HER2).