Patent ID: 7355079

Claim:
A compound of formula IV: or a stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate, N-oxide or isomorphic crystalline form therof; wherein independently, R 1 and R 2 are H, lower alkyl, cyclic alkyl, or benzyl; Y is â€”[C(Râ€²Râ€³)] n â€”, where Râ€² is H, and Râ€³ is aryl optionally substituted with 1-3 substituents selected from the group consisting of lower alkyl, halo, hydroxyl, and alkoxy; or benzyl wherein the phenyl portion thereof is optionally substituted with 1-3 substituents selected from the group consisting of lower alkyl, halo, hydroxyl, and alkoxy; Z is â€”[C(R) 2 ] n â€”, CHOR, O, S, NR, CONH, or NHCO; R 3 , R 4 , R 5 , and R 7 I, Br, Cl, F, H, CH 3 , CF 3 , CN, SR, OCH 3 , CH 2 CH 3 , or CH(CH 3 ) 2 ; R 6 is OH, H, SH, F, CF 3 , lower alkyl, or N(R) 2 ; R 8 is OR, R, CH 2 OR, CH 2 NR 2 , CH 2 N + R 3 , SR, or CH 2 SR; X is O, S, SO, SO 2 , NR, C(R) 2 , -lower alkyl-Oâ€”, â€”O-lower alkyl-, COCH 2 O, or OCH 2 CO; R is H, lower alkyl, aryl optionally substituted with 1-3 substituents selected from the group consisting of lower alkyl, halo, hydroxy, and alkoxy; or benzyl wherein the phenyl portion thereof is optionally substituted with 1-3 substituents selected from the group consisting of lower alkyl, halo, hydroxy, and alkoxy; and n is 1 to 6.