Patent ID: 8022209

Claim:
A process for the preparation compounds of formula (I-P), pharmaceutically acceptable salts of compounds of Formula (I-P), pharmaceutically acceptable prodrugs of compounds of Formula (I-P), and pharmaceutically active metabolites of compounds of Formula (I-P), wherein A is selected from the group consisting of H and C 1-4 alkyl; R 1 is selected from the group consisting of aryl and heteroaryl; wherein said aryl or heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy substituted C 1-4 alkyl, C 2-4 alkenyl, C 1-4 alkoxy, cyano, nitro, NR A R B , —C 1-4 alkyl-O—C 1-4 alkyl, —C 1-4 alkyl-NR A R B , phenyl, Sph, and 5 to 6 membered heteroaryl; R A and R B are each independently selected from the group consisting of H and C 1-4 alkyl; Sph is phenyl substituted with one or more substituents independently selected from the group consisting of halo, cyano, C 1-4 alkyl, C 1-4 alkoxy, —NR C R D , —C(O)—NR C R D , —C(O)OH, —C(O)O—C 1-4 alkyl, (—C(O)-4-morpholinyl), (—C(O)-1-pyrrolidinyl) and (—NR E —C(O) —C 1-4 alkyl); R C and R D are each independently selected from the group consisting of H and C 1-4 alkyl; alternatively, R C and R D are taken together with the nitrogen atom to which they are bound to from a 5 to 6 membered, saturated, nitrogen-containing ring; R E is selected from the group consisting of H and C 1-4 alkyl; a is 1; R 2 is selected from the group consisting of H and C 1-4 alkyl; comprising: reacting a compound of formula (XIII) with a compound of formula (XV) in an anhydrous organic solvent.