Patent ID: 7071208

Claim:
A compound of the formula: wherein: m is 1,2,3,4 or 5; n is 0, 1 or 2; A 1 , A 2 and A 3 are carbon; Het is thien-2-yl optionally substituted with COCH 3 ; R 1 and R 2 are H; R 3 is H or C 1 –C 6 alkyl; R 4 and R 5 are independently at each occurrence H or C 1 –C 6 alkyl; or R 4 and R 5 combine with the carbon to which they are both attached to form a C 3 –C 7 carbocyclic ring; R 6 is independently at each occurrence halo, hydroxyl, cyano, C 1 –C 6 alkyl, C 1 –C 4 haloalkyl or C 1 –C 6 alkoxy; R 7 is H, CO 2 R 8 , CONR 8 R 8 , CH═CHR 9 , CH 2 CH 2 R 9 , NR 8 R 8 , NR 8 SO 2 R 8 , O(CR 10 R 11 ) p R 12 , O(CR 10 R 11 ) q R 13 , SO 2 R 8 , SO 2 NR 8 R 8 , optionally substituted phenyl where when substituted has one to three groups independently selected from halo, hydroxy, oxo, cyano, nitro, phenyl, benzyl, C 1 –C 6 alkyl, C 1 –C 4 haloalkyl, C 1 –C 6 alkoxy, COR 17 , CONR 17 R 17 , CO 2 R 17 , NR 17 R 17 , NR 17 COR 18 , NR 17 SO 2 R 18 , OCOR 18 , OCO 2 R 17 , OCONR 17 R 17 , SR 17 , SOR 18 , SO 2 R 18 and SO 2 (NR 17 R 17 ), where R 17 is independently at each occurrence H, C 1 –C 6 alkyl, phenyl or benzyl and R 18 is independently at each occurrence C 1 –C 6 alkyl, phenyl or benzyl; X is OCH 2 ; p is 0, 1, 2 or 3; q is 1, 2 or 3; R 8 is independently at each occurrence H, C 1 –C 6 alkyl or phenyl; R 9 is cyano, CO 2 R 14 , CONR 14 R 14 , CONR 14 SO 2 R 14 , SO 2 R 14 or optionally substituted phenyl where when substituted has one to three groups independently selected from halo, hydroxy, oxo, cyano, nitro, phenyl, benzyl, C 1 –C 6 alkyl, C 1 –C 4 haloalkyl, C 1 –C 6 alkoxy, COR 17 , CONR 17 R 17 , CO 2 R 17 , NR 17 R 17 , NR 17 COR 18 , NR 17 SO 2 R 18 , OCOR 18 , OCO 2 R 17 , OCONR 17 R 17 , SR 17 , SOR 18 , SO 2 R 18 and SO 2 (NR 17 R 17 ), where R 17 is independently at each occurrence H, C 1 –C 6 alkyl, phenyl or benzyl and R 18 is independently at each occurrence C 1 –C 6 alkyl, phenyl or benzyl; R 10 and R 11 are independently at each occurrence H or C 1 –C 6 alkyl; R 12 is hydrogen, CO 2 R 15 , CONR 15 R 15 , SO 2 R 15 , SO 2 NR 16 R 16 , pyridyl or optionally substituted phenyl where when substituted has one to three groups independently selected from halo, hydroxy, oxo, cyano, nitro, phenyl, benzyl, C 1 –C 6 alkyl, C 1 –C 4 haloalkyl, C 1 –C 6 alkoxy, COR 17 , CONR 17 R 17 , CO 2 R 17 , NR 17 R 17 , NR 17 COR 18 , NR 17 SO 2 R 18 , OCOR 18 , OCO 2 R 17 , OCONR 17 R 17 , SR 17 , SOR 18 , SO 2 R 18 and SO 2 (NR 17 R 17 ), where R 17 is independently at each occurrence H, C 1 –C 6 alkyl, phenyl or benzyl and R 18 is independently at each occurrence C 1 –C 6 alkyl, phenyl or benzyl; R 13 is cyano, NR 16 R 16 , NR 16 SO 2 R 16 or OR 16 ; R 14 , R 15 and R 16 are independently at each occurrence H, C 1 –C 6 alkyl or phenyl; or a pharmaceutical salt thereof.