Patent ID: 8058282

Claim:
A compound of the formula: wherein R 1 is an optionally substituted aryl or an optionally substituted heteroaryl ring; R 2 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylalkyl, aryl, arylC 1-10 alkyl, heteroaryl, heteroarylC 1-10 alkyl, heterocyclic, or a heterocyclylC 1-10 alkyl moiety, which moieties are all optionally substituted, or R 2 is the moiety X 1 (CR 10 R 20 ) q C(A 1 )(A 2 )(A 3 ), or C(A 1 )(A 2 )(A 3 ); A 1 is an optionally substituted C 1-10 alkyl; A 2 is an optionally substituted C 1-10 alkyl; A 3 is hydrogen or is an optionally substituted C 1-10 alkyl; R 3 is an C 1-10 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, aryl, arylC 1-10 alkyl, heteroaryl, heteroarylC 1-10 alkyl, heterocyclic, or a heterocyclylC 1-10 alkyl moiety, which moieties are optionally substituted; R 4 and R 14 are each independently selected from hydrogen, optionally substituted C 1-4 alkyl, optionally substituted C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, optionally substituted aryl, or optionally substituted aryl-C 1-4 alkyl, or R 4 and R 14 together with the nitrogen which they are attached form an optionally substituted heterocyclic ring of 4 to 7 members, which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR 9 ; R 6 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, heterocyclyl, heterocyclyl C 1-10 alkyl, aryl, arylC 1-10 alkyl, heteroaryl or heteroarylC 1-10 alkyl, wherein each of these moieties may be optionally substituted; R 9 is hydrogen, C(Z)R 6 or optionally substituted C 1-10 alkyl, optionally substituted aryl or optionally substituted aryl-C 1-4 alkyl; R 10 and R 20 are independently selected from hydrogen or C 1-4 alkyl; X is R 2 , OR 2 , S(O) m R 2 , (CH 2 ) n N(R 10 )S(O) m R 2 , (CH 2 ) n N(R 10 )C(O)R 2 , (CH 2 ) n NR 4 R 14 , or (CH 2 ) n N(R 2 ) 2 ; X 1 is N(R 10 ), O, S(O) m , or CR 10 R 20 ; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; q is 0 or an integer having a value of 1 to 10; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof.