Patent ID: 7122533

Claim:
A method of inhibiting effective binding of a chemokine to its cellular receptor, comprising contacting a cellular population with an effective amount of a compound having the following structure: wherein: R 1 to R 11 are independently H, a halogen, hydroxy, amino, alkoxy having 1 to 5 carbon atoms, benzoyloxy, R 14 C(O)O, where R 14 is H or C 1 –C 5 alkyl; COOH or a salt thereof, SO 3 H or a salt thereof, PO 3 H 2 or a salt thereof, C 1 –C 24 alkyl, COOR 15 where R 15 is aryl or C 1 –C 5 alkyl; SO 3 R 16 , where R 16 is aryl or C 1 –C 5 alkyl; C(O)NR 17 R 18 where R 17 and R 18 are each independently H, C 1 –C 5 alkyl, aryl, or hydroxy; SO 2 NR 19 R 20 where R 19 and R 20 are each independently H, C 1 –C 5 alkyl, or aryl; SR 21 where R 21 is C 1 –C 5 alkyl or aryl; SCH 2 R 25 , where R 25 is aryl; SC(O)R 21 where R 21 is as defined above; NR 22 R 23 where R 22 and R 23 are each independently H, C 1 –C 5 alkyl, or aryl; NHC(O)—R 24 , where R 24 is aryl optionally substituted with COOH or a salt thereof, or C 1 –C 7 alkoxy; O(CH 2 ) n —R 26 —R 27 , where n is 1 to 7, R 26 is aryl, R 27 is COOH or a salt thereof, B(OH) 2 or a salt thereof, nitro, C 1 –C 7 alkoxy, or aryl wherein the aryl of R 27 is substituted with COOH or a salt thereof, B(OH) 2 or a salt thereof, nitro, or C 1 –C 7 alkoxy; OC(O)NHCH(R 28 )COOR 29 or C(O)NHCH(R 28 )COOR 29 , wherein R 28 is an amino acid side chain and R 29 is H or a C 1 –C 4 alkyl; R 12 and R 13 are C 1 –C 7 alkyl; X is a (C 1 –C 7 alkylene) or (C 1 –C 7 alkylene)C(O)NH; or a pharmaceutically acceptable salt thereof.