Patent ID: 8173636

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: R 2 is cyano, amino, nitro, —COR b , —SO 2 R b , trifluoromethyl, or phenyl substituted with 0 to 2 substituents independently chosen from halogen, C 1 -C 2 alkyl, or C 1 -C 2 alkoxy, where R b is hydroxyl, C 1 -C 6 alkoxy, C 1 -C 6 alkyl, aryl, aryloxy, —N(R a ) 2 , or trifluoromethyl; and R a is independently chosen at each occurrence from hydrogen, C 1 -C 6 alkyl, and aryl; R 5 is hydrogen, hydroxyl, halogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; R 6 is hydrogen or halogen; R 7 is phenyl or a C-linked 5- to 6-membered partially unsaturated heterocyclic group; or R 7 is a nitrogen-linked heterocycloalkyl group, which has 1 ring or 2 fused rings, a total of 4 to 8 ring members, including 0, 1, or 2 additional ring heteroatoms independently chosen from N, O, and S, or R 7 is a nitrogen-linked 6-membered heterocycloalkyl group, having 0, 1 or 2 additional ring heteroatoms independently chosen from N, O, and S, and bridged with a methylene or ethylene bridge; Each of which R 7 is substituted with 0 or 1 or more substituents independently chosen from (a) and 0 or 1 substituents chosen from (b); wherein (a) is chosen from halogen, hydroxyl, amino, nitro, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 6 alkoxy, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and aminoC 1 -C 2 alkyl, and (b) is oxo, amino, —CONH 2 , C 1 -C 4 alkyl substituted with at least one hydroxyl or cyano, C 1 -C 6 alkylthio, C 2 -C 6 alkanoyl, (mono- or di-C 1 -C 4 alkyl)aminoC 0 -C 4 alkyl, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, (C 3 -C 7 cycloalkyl)aminoC 0 -C 4 alkyl, (C 3 -C 7 cycloalkyl) (C 1 -C 4 alkyl)aminoC 0 -C 4 alkyl, (heterocycloalkyl)C 0 -C 4 alkyl, (5-membered heteroaryl)C 0 -C 4 alkyl, (aryl)C 0 -C 4 alkyl, or R 10 —O—N═, where R 10 is hydrogen or C 1 -C 6 alkyl, or R 13 R 14 C═ where R 13 is halogen and R 14 is aminoC 1 -C 4 alkyl; where each of (b) other than oxo, cyano, and —CONH 2 , is substituted with 0 to 2 substituents independently chosen from halogen, hydroxyl, amino, cyano, nitro, oxo, —COOH, —CONH 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 8 is methoxy or difluoromethoxy; and R 9 is C 1 -C 4 alkyl, C 3 -C 7 cycloalkyl, phenyl, or pyridyl, each of which R 9 is substituted with 0 to 3 substituents independently chosen from amino, halogen, C 1 -C 4 alkyl, and C 1 -C 4 alkoxy; or R 8 and R 9 are joined to form a 6-membered ring optionally containing one additional heteroatom chosen from N, O, and S, and optionally containing one carbon-carbon double bond.