Patent ID: 7259234

Claim:
A proteinase-resistant analog of GLP-1 with an amino acid sequence represented by: Xaa-Ala-Yaa-R wherein Xaa is His; R is a polypeptide having an amino acid sequence selected from the group consisting of GTFTSDVSSYLEGQAAKEFIAWLVKGRG, GTFTSDVSSYLEGQAAKEFIAWLVKGR—NH 2 , GTFTSDVSSYLEGQAAKEFIAWLVKGR, GTFTSDVSSYLEGQAAKEFIAWLVKGRPSSGAPPPS—NH 2 , GTFTSDLSKEMEEEAVRLFIEWLKNGGPSSGAPPPS, and GTFTSDLSKEMEEEAVRLFIEWLKNGGPSSGAPPPS—NH 2 ; and Yaa is an amino acid analog of Formula II: wherein R 1 and R 2 are independently for each occurrence lower alkyl or halogen; R 3 is selected from the group consisting of lower alkyl, aryl, —OH, —(CH 2 ) m —COOH, —(CH 2 ) m —NH 2 , —(CH 2 ) m —N—C(═NH)NH 2 , —(CH 2 ) m —C(═O)NH 2 , —SH, and —(CH 2 ) m —S—CH 3 ; and m is 0, 1, or 2.