Patent ID: 8080656

Claim:
A process for the preparation of Aprepitant of Formula I or a salt thereof, wherein said process comprises: a) treating a compound of Formula III, with L-Selectride, b) reacting the mixture of step a) with the compound of Formula IV, to obtain a compound of Formula II, c) crystallizing the compound of Formula II from an organic solvent, d) isolating a highly pure compound of Formula II from the reaction mass thereof, e) reacting the highly pure compound of Formula II with dimethyl titanocene to obtain a compound of Formula V, f) hydrogenating the compound of Formula V to obtain a compound of Formula VI, g) reacting the compound of Formula VI or an acid addition salt thereof with N-methylcarboxy-2-chloroacetamidrazone, to obtain a compound of Formula VII, h) cyclising the compound of Formula VII, to obtain Aprepitant of Formula I.