Patent ID: 7858588

Claim:
A method of stimulating a T cell response comprising: obtaining a pharmaceutical composition comprising an antigen and an oligodeoxynucleic acid molecule (ODN) having a structure of formula (I): wherein: any X is O or S; any NMP is a 2′ deoxynucleoside-monophosphate or -monothiophosphate, further defined as deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, or deoxyuridine-aa deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, 6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine-, or N-isopentenyl-deoxyadenosine-monophosphate or -monothiophosphate, and wherein at least one of the NMPs immediately 5′ or 3′ adjacent to the deoxyuridine is a 2′-deoxycytosine-monophosphate or monothiophosphate; NUC is a 2′ deoxynucleoside, further defined as deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxythymidine-, 2-methyl-deoxyuridine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, 6-S-deoxyguanine-, dimethyl-deoxyguanosine-, or N-isopentenyl-deoxyadenosine; a and b are integers from 0 to 100, with the proviso that a+b is between 4 and 150; and B and E are common groups for 5′ or 3′ ends of nucleic acid molecules; and administering the pharmaceutical composition to a subject; wherein the ODN does not contain a CpG motif.