Patent ID: 8889676

Claim:
A compound of formula I wherein R 1 is (C 1 -C 3 )alkyl, (C 2 -C 3 )haloalkyl or cyclopropyl; R 2 is H, halogen, pyridazin-4-yl, pyrimidin-5-yl or a group having the formula (A1), (A2) or (A3) shown hereafter wherein R x is H and each of R y and R z is independently H or methyl, or each of R x and R z is H and R y is halogen, cyano, (C 2 -C 4 )alkyl, (C 1 -C 4 )alkoxy, amino, hydroxy, hydroxy-(C 1 -C 3 )alkyl, trifluoromethyl, carbamoyl, carbamoyl-(C 1 -C 2 )alkyl, (methylcarbamoyl)-(C 1 -C 2 )alkyl, (dimethylcarbamoyl)-(C 1 -C 2 )alkyl, tert-butoxycarbonylmethyl, cyclopropyl, pyrrolidin-1-yl, piperidin-1-yl, morpholin-1-yl or 1-morpholinomethyl, or R x is H and each of R y and R z is independently halogen, or R x is methyl, R y is methyl or halogen and R z is H, or R x is methyl or halogen, R y is H and R z is methyl or halogen, or R x is methyl or halogen and each of R y and R z is H; R x2 is H, amino or hydroxymethyl; R x3 is hydroxy, carboxy, carbamoyl, hydroxymethyl or aminomethyl, R y3 is H and R z3 is H or each of R x3 and R z3 is H and R y3 is hydroxy, acetamidomethyl, (dimethylamino)methyl, carboxymethyl, carbamoyl or aminomethyl, or each of R x3 and R y3 is H and R z3 is hydroxy; R 3 is (C 1 -C 4 )alkyl, (C 2 -C 4 )alkynyl, amino-(C 1 -C 3 )alkyl, carbamoyl-(C 1 -C 3 )alkyl, (methylcarbamoyl)-(C 1 -C 3 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 3 -C 4 )alkynyloxy, (4-hydroxybut-2-yn-1-yl)oxy, (4-aminobut-2-yn-1-yl)oxy, dimethylamino-(C 2 -C 3 )alkoxy, carbamoyl-(C 1 -C 3 )alkoxy, (C 1 -C 3 )alkylamino, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 4 )alkoxy, hydroxy-(C 1 -C 3 )alkyl, hydroxy-(C 2 -C 3 )alkoxy, (C 1 -C 3 )alkoxy-(C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy-(C 1 -C 3 )alkoxy, carboxy-(C 1 -C 3 )alkyl, carboxy-(C 1 -C 3 )alkoxy, (C 1 -C 2 )alkoxycarbonyl-(C 1 -C 3 )alkoxy, aryl, (C 5 -C 6 )heteroaryl, benzyl, benzyloxy, 2-cyanoethoxy, 2,3-dihydroxypropoxy, 3,4-dihydroxybutoxy, —CH 2 R a , —CH 2 CH 2 R b , —(CH 2 ) n —C(O)O—R d , —(CH 2 ) n —N(R c )C(O)O—R d , —O—(CH 2 ) n —N(R c )C(O)O—R d , —(CH 2 ) n —R e or —O—(CH 2 ) n —R e ; n is 1, 2 or 3; R a is cyano, acetylamino, N,N-dimethylamino; and R b is cyano or carbamoyl; R c is H or methyl; R d is (C 1 -C 4 )alkyl; R e is pyrrolidin-1-yl, piperidin-1-yl, piperidin-3-yl, morpholin-1-yl, 2-oxopyrrolidin-1-yl, 5-oxopyrrolidin-2-yl, 2,5-dioxopyrrolidin-1-yl, 2-oxoimidazolidin-1-yl, 4-(tert-butoxycarbonyl)piperazin-1-yl, 4-(aminomethyl)cyclohexyl or (C 5 -C 6 )heteroaryl; R 4 is H or methyl; or a salt thereof.