Patent ID: 7147837

Claim:
A composition of matter having the following formula: IEM-PBM-[L]-[MS-MM] p , wherein p is 1; wherein L comprises a physiologically compatible linker moiety which links the PBM and [MS-MM] moieties; wherein said IEM comprises a complex between: (1) a chelating agent selected from the group consisting of DTPA, DOTA, DTPA-BMA, and HP-DO3A, and (2) one or more paramagnetic metal ions (M) with atomic numbers 21–29, 42, 44, or 57–83; wherein said -PBM moiety is selected from the group consisting of: wherein one aryl ring of said -PBM is substituted with said -[L]-[MS-MM] p moiety; wherein R is selected from the group consisting of aliphatic group, an aryl group, or a cycloalkyl group; wherein the wavy line signifies the attachment site for the IEM; wherein said -PBM moiety is conjugated to said IEM via a covalent bond to a methylene carbon of said chelating agent of said IEM; wherein said MS moiety is an amide bond; wherein said MM moiety is a peptide consisting of two or three amino acids; and pharmaceutically acceptable salts thereof.