Patent ID: 8017152

Claim:
A process for producing parenterally acceptable cores which comprises the following steps: a) preparing an aqueous polymer solution of at least one polymer, said polymers being acceptable for parenteral administration and selected from protamin, polyarginine, polyomithine, sodium carboxymethylcellulose, maltodextrin, dextran, glycogen, hyaluronic acid, chondroitin sulphate, dermatan sulfate, polyvinylpyrrolidone, polyethyleneglycol and polyethyleneoxide, wherein the polymer concentration is in the range 0.5-15%, with the proviso that when the dispersing in step d) is carried out by atomization said polymer concentration is less than 5%, b) providing at least one parenterally administrable biologically active substance in undissolved form, c) combining the polymer solution of step a) with the biologically active substance of step b), in a ratio to said polymer such that when expressed by weight percentage the biologically active substance constitutes at least 30 percent of the dry weight of the combined weight of said polymer and said biologically active substance, d) dispersing the composition obtained in step c) as a discontinuous phase in a continuous phase, e) solidifying the composition, to provide cores suitable for air suspension coating, wherein the obtained cores have a size distribution such that at least 80% of the obtained cores measure from 10-200 μm.