Patent ID: 8283370

Claim:
A compound having the formula I: or a tautomer thereof, or their pharmaceutically acceptable salts, wherein: R 1 is aryl or heteroaryl, each optionally substituted with one or more R 1a ; each R 1a is independently selected from the group consisting of hydroxyl, carboxyl, halo, aralkyl, amino, alkylamino, dialkylamino, alkoxycarbonyl, alkylsulfonyl, heterocycle, aryl, C 3-7 cycloalkyl, C 1-6 alkyl optionally substituted with up to 5 fluoro, and C 1-6 alkoxy, optionally substituted with up to 5 fluoro; R 2 is an optionally substituted substituent selected from the group consisting of C 1-10 alkyl, C 2-10 alkenyl, C 3-10 cycloalkyl(CH 2 ) n —, aryl(CH 2 ) n —, heteroaryl(CH 2 ) n —, alkylaryl, heterocyclyl(CH 2 ) n —, aminoalkyl, R 2a R 2b N(CH 2 ) n —, or R 2 is R 5 O—; n is an integer selected from 0, 1, 2, 3, 4, 5, 6, or 7; R 2a is selected from the group consisting of hydrogen, alkoxycarbonyl, alkylsulfonyl, heterocycle, aryl, C 3-7 cycloalkyl, C 1-6 alkyl optionally substituted with up to 5 fluoro, and C 1-6 alkoxy optionally substituted with up to 5 fluoro; R 2b is selected from the group consisting of hydrogen, alkoxycarbonyl, alkylsulfonyl, heterocycle, aryl, C 3-7 cycloalkyl, C 1-6 alkyl optionally substituted with up to 5 fluoro, and C 1-6 alkoxy optionally substituted with up to 5 fluoro; R 3 is C 1-10 alkyl optionally substituted with up to 5 fluoro; and R 5 is an optionally substituted substituent selected from the group consisting of C 1-10 alkyl, C 2-10 alkenyl, C 3-10 cycloalkyl(CH 2 ) n —, aryl(CH 2 ) n —, heteroaryl(CH 2 ) n —, alkylaryl, heterocyclyl(CH 2 ) n —, aminoalkyl, and R 2a R 2b N(CH 2 ) n —.