Patent ID: 7151105

Claim:
A compound of formula (4), wherein: R 1 is cyclopentyl; R 2 is —(CR 6 R 7 ) n (5–6 membered heterocyclic), wherein said 5–6 membered heterocyclic group is optionally substituted with at least one R 4 group; R 3 is —(CR 6 R 7 ) t (C 6 –C 10 aryl) or —(CR 6 R 7 ) t (4–10 membered heterocyclic), wherein each of said C 6 –C 10 aryl and 4–10 membered heterocyclic moieties of said R 3 groups are optionally substituted with at least one R 5 group; each R 4 is independently selected from halo, —OR 8 , oxo, —NR 6 R 7 , —CF 3 , —CN, —C(O)R 6 , —C(O)OR 6 , —OC(O)R 6 , —NR 6 C(O)R 7 , —NR 6 C(O)OR 7 , —NR 6 C(O)NR 6 R 7 , —C(O)NR 6 R 7 , —SO 2 NR 6 R 7 , —NR 6 SO 2 R 7 , C 1 –C 6 alkyl, C 2 –C 6 alkenyl, and C 2 -C 6 alkynyl, wherein said C 1 -C 6 alkyl, C 2 –C 6 alkenyl, and C 2 -C 6 alkynyl groups are optionally substituted with at least one R 5 ; each R 5 is independently selected from C 1 -C 6 alkyl, halo, —OR 6 , —CF 3 , and —CN; each R 6 and R 7 is independently selected from hydrogen and C 1 -C 6 alkyl; n is 0, 1, 2, 3, 4, or 5; and t is 0, 1, 2, 3, 4, or 5; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compound of formula (4) is not 6-cyclopentyl-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-6-[2-(2-ethylpyridin-4-yl)ethyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one, 3-[(6-chloro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-6-cyclopentyl-6-[2-(2-ethylpyridin-4-yl)ethyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one, or 6-cyclopentyl-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-6-[2-(5-ethylpyridin-3-yl)ethyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one.