Patent ID: 7785566

Claim:
A compound of Formula I Z- L -V (I) wherein V denotes a peptide with a binding sequence Gly-X 2 Val-Tyr-Ile-His-Pro-X 3 , L denotes a bond or a linker of formula —NH—(CH 2 ) m — optionally combined with —CO—(CH 2 ) m —CO— where m denotes a positive integer from 1 to 10, Z denotes a chelating agent of formula (VII) wherein: each R 1 , R 2 , R 3 and R 4 is independently H or C 1-10 alkyl, C 3-10 alkylaryl, C 2-10 alkoxyalkyl, C 1-10 hydroxyalkyl, C 1-10 alkylamine, C 1-10 fluoroalkyl, or 2 or more R groups, together with the atoms to which they are attached form a carbocyclic, heterocyclic, saturated or unsaturated ring, that optionally can carry an imaging moiety M, X 2 denotes Arg, N-alkylated Arg, or Phe[4-guanidino] or Gly-4-piperidyl [N-amidino], X 3 denotes an amino acid containing a hydrophobic side-chain, and wherein the residues Val and Ile at position 3 and 5 respectively may optionally be replaced with amino acids capable of forming a bridge containing a —CH 2 —CH 2 —, —S—CH 2 —, —S—CH 2 —S—, lactam or —S—S— unit, Z forms a bond with the amino acid Gly optionally through the linker L, and M where present denotes a gamma emitting moiety for Radio or SPECT imaging selected from the group of 67 Ga, 111 In, 123 I, 125 I, 131 I, 81m Kr, 99 Mo, 99m Tc, 201 Tl and 133 Xe.