Patent ID: 6936261

Claim:
A method of eliciting broad spectrum protective immunity against Neisseria meningitidis , said method comprising the steps of: administering to a mammal a first preparation of microvesicles (MVs) from a first Neisseria meningitidis species that is a member of a first serotype and of a first serosubtype, in an amount sufficient to elicit an immune response to epitopes present in said first preparation; and administering to said mammal a second preparation of MVs from a second Neisseria meningitidis species that is a member of a second serotype and of a second serosubtype, in an amount sufficient to elicit an immune response to epitopes present in said second preparation; wherein the serotype or serosubtype of each of the first and second Neisseria meningitidis species is different, and wherein administering of the first and second preparations is sufficient to elicit an immune response in said mammal, wherein said immune response confers protective immunity against more than one strain of Neisseria meningitidis species.