Patent ID: 8134025

Claim:
A method of fabricating mesocrystals of racemic (R,S)-(±)-sodium ibuprofen dihydrate, comprising the steps of: (a) obtaining a mixture of racemic (R,S)-(±)-sodium ibuprofen dihydrate and a surfactant; (b) obtaining a supersaturated solution with said racemic (R,S)-(±)-sodium ibuprofen dihydrate and said surfactant, placing said supersaturated solution in a glass vial having a cross-shaped magnetic spin bar, and placing said glass vial in a crystallizer; and (c) obtaining a mesocrystal through a water bath with a crystallizer having three constant temperature tanks, comprising the steps of: (c1) processing a stirring in said glass bottle located in a first constant temperature tank of said crystallizer; (c2) placing said glass bottle in a second constant temperature tank of said crystallizer and processing a stirring to completely dissolve said organic or organo-metallic compound, wherein said second constant temperature tank has a higher temperature than said first constant temperature tank; (c3) placing said glass vial back to said first constant temperature tank and staying said glass vial still for a period of time; (c4) rapidly moving said glass vial to a third constant temperature tank of said crystallizer to obtain a mesocrystal in said glass bottle, wherein said third constant temperature tank has a lower temperature than said first constant temperature tank.