Patent ID: 8016783

Claim:
A system, comprising: a transdermal drug delivery device adapted to deliver a drug; an implantable cardiac rhythm management (CRM) device communicatively coupled to the transdermal drug delivery device, the implantable CRM device including: an ischemia detector adapted to detect an ischemia and produce an ischemia indicating signal in response to a detection of the ischemia; a drug level detector including a respiratory sensor adapted to sense a respiratory signal as an indication of whether a blood drug concentration is below a predetermined minimum level after a delivery of the drug; and a drug delivery controller coupled to the ischemia detector and the drug level detector; and an external device communicatively coupled to the implantable CRM device, the external device including an external user input to receive an external user command, wherein the drug delivery controller is adapted to control the transdermal drug delivery device based on at least one of the ischemia indicating signal, the indication of the blood drug concentration, and the external user command.