Patent ID: 8722716

Claim:
A method of inducing insulin production and/or secretion from an islet β-cell comprising contacting said cell with a compound of formula (I): wherein: R 1 is substituted or unsubstituted phenyl, substituted or unsubstituted thiophenyl or a substituent of formula (A): wherein: R 4 , R 5 and R 6 are each independently hydrogen, hydroxy, halo, cyano, nitro; or alkyl (C≦10) , aryl (C≦12) , aralkyl (C≦15) , heteroaryl (C≦12) , acyl (C≦10) or a substituted version of any of these groups; and G is O, —NH, or S; R 2 is: hydrogen, hydroxy, halo, or nitro; or alkyl (C≦10) , alkenyl (C≦10) , alkynyl (C≦10) , alkoxy (C≦10) , alkenyloxy (C≦10) , alkynyloxy (C≦10) , aryl (C≦12) , aralkyl (C≦15) , acyl (C≦10) , or a substituted version of any of these groups; or —C(O)R 7 , —OC(O)R 7 , —OC(O)OR 7 , —C(O)NR 8 R 9 , —OC(O)NR 8 R 9 , —NR 8 OR 9 , or —SO 3 R 7 ; wherein R 7 is hydrogen, alkyl (C≦10) , aryl (C≦12) , aralkyl (C≦15) ; R 8 and R 9 are each independently hydrogen, alkyl (C≦10) , aryl (C≦12) , aralkyl (C≦15) , or taken together are alkanediyl (C≦6) ; R 3 is —NH—O-alkyl (C≦10) , —NHOH, —OR 10 or —NR 11 R 12 , wherein R 10 is hydrogen, substituted or unsubstituted alkyl (C≦10) , substituted or unsubstituted alkenyl (C≦10) , substituted or unsubstituted alkynyl (C≦10) , substituted or unsubstituted aryl (C≦12) , or substituted or unsubstituted aralkyl (C≦15) ; R 11 and R 12 are each independently hydrogen, substituted or unsubstituted alkyl (C≦10) , substituted or unsubstituted alkenyl (C≦10) , substituted or unsubstituted alkynyl (C≦10) , substituted or unsubstituted aryl (C≦12) , or substituted or unsubstituted aralkyl (C≦15) ; or R 11 and R 12 are taken together to form alkanediyl (C≦6) , —CH 2 CH 2 NHCH 2 CH 2 —, or —CH 2 CH 2 OCH 2 CH 2 —; or R 11 and R 12 are taken together to form alkanediyl (C≦6) ; or pharmaceutically acceptable salt thereof.