Patent ID: 8273737

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X 1 is selected from the group consisting of (1) N, (2) S, (3) SO 2 , or (4) O; X 2 is CHR 7 or CH 2 CHR 7 ; R 1 and R 2 are each selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, (3) —C 6-10 aryl, (4) —C(═O)—OR 6A , or (5) OH, wherein the alkyl or aryl moiety of R 1 and R 2 is optionally substituted by one or more (b) halogen, (b) —C 1-6 alkyl, wherein said alkyl is optionally substituted with one or more halogen, or R 1 and R 2 together form the group ═O; R 7 is hydrogen or R 1 and R 7 are linked together to form —CH 2 — or —CH 2 CH 2 —; R 3 is selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, (3) —(CH 2 ) n -aryl, (4) heteroaryl group having 5 to 12 ring atoms, (5) —C 4-12 non-aromatic heterocyclic group, (6) —C 3-12 cycloalkyl, (7) —S(O) m —R 6A , (8) cyano, wherein said alkyl, aryl, heteroaryl, heterocyclic or cycloalkyl moiety of R 3 is optionally substituted with one or more (a) halogen, (b) hydroxy, (c) cyano, (d) —(CH 2 ) q -aryl, (e) —C(═O)—OR 6A , (f) —O—C 1-6 alkyl, (g) —C 1-6 alkyl, (h) —C 2-6 alkenyl (i) —C 2-6 alkynyl, (j) —NO 2 , (k) —N(R 6A R 6B ), and wherein said alkyl, alkenyl, alkynyl or aryl moiety of (d),(f),(g),(h), and (i) is optionally substituted with one or more (i) halogen, (ii) hydroxy, (iii) cyano, (iv) —S(O) m —R 6A ; R 4 is selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, and (3) —CH 2 -aryl, wherein said alkyl or aryl moiety of R 4 is optionally substituted with one or more (a) halogen, (b) cyano, and (c) —O—C 1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo; R 5 is selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, (3) —(CH 2 ) n -aryl, or (4) heteroaryl group having 5 to 12 ring atoms, wherein said alkyl, aryl or heteroaryl moiety of R 5 optionally substituted with one or more (a) halogen, (b) hydroxy, (c) cyano, (d) —(CH 2 ) q -aryl, (e) —O—C 1-6 alkyl, (f) —C 1-6 alkyl, (g) —N(R 6A R 6B ), and wherein said alkyl or aryl moiety of (d) and (e) is optionally substituted with one or more (i) halogen, (ii) hydroxy, (iii) cyano, (iv) —S(O) m —R 6A ; R 6A and R 6B are independently selected from the group consisting of (1) hydrogen, (2) —C 1-6 alkyl, and (3) —(CH 2 ) m -aryl, wherein said alkyl or aryl moiety of R 6A or R 6B is optionally substituted with one or more (a) halogen, (b) cyano, and (c) —O—C 1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo; m, n and q are each selected from 0, 1 or 2; provided that if X 1 is O, S or SO 2 then X 2 is —CH 2 — and R 3 is absent.