Patent ID: 7304054

Claim:
A compound of Formula I, Formula Ia, Formula Ib or Formula Ic: wherein, W 1 , W 2 and W 3 are each independently selected from the group consisting of Z is selected from the group consisting of —CH═O, —CH(OC 1-6 alkyl) 2 , —CH 2 OH, —CH 2 OC 1-6 alkyl and —C(O)OR 7 ; R 1 is selected from the group consisting of H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 6-10 aryl, a 5-10 member heteroaryl, C 3-10 cycloalkyl, a 3-10 member heterocycloalkyl, C(O)H, C(O)C 1-10 alkyl, C(O)C 2-10 alkenyl, C(O)C 2-10 alkynyl, C(O)C 6-10 aryl, C(O)heteroaryl, wherein the heteroaryl has 5-10 members, C(O)C 3-10 cycloalkyl; C(O)heterocycloalkyl, wherein the heterocycloalkyl has 3-10 members, and a C-coupled amino acid; R 2 , R 3 , and R 4 are each independently selected from the group consisting of H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 6-10 aryl, a 5-10 member heteroaryl, C 3-10 cycloalkyl, a 3-10 member heterocycloalkyl, C(O)H, C(O)C 1-10 alkyl, C(O)C 2-10 alkenyl, C(O)C 2-10 alkynyl, C(O)C 6-10 aryl, C(O)heteroaryl, wherein the heteroaryl has 5-10 members, C(O)C 3-10 cycloalkyl; C(O)heterocycloalkyl, wherein the heterocycloalkyl has 3-10 members, and a C-coupled amino acid; R 5 and R 6 are each independently selected from the group consisting of H, OH, OC 1-6 alkyl, OC(O)C 1-6 alkyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , and NHC(O)C 1-6 alkyl; R 7 is selected from the group consisting of H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 6-10 aryl, a 5-10 member heteroaryl, C 3-10 cycloalkyl and a 3-10 member heterocycloalkyl; X 1 , X 2 , X 3 , X 4 and X 5 are each H; or one of X 1 , X 2 , X 3 , X 4 or X 5 is halogen and the remaining ones are H; and wherein, when any of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 comprises an alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group, the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group is optionally substituted with substituents selected from the group consisting of acyl, amino, acylamino, acyloxy, carboalkoxy, carboxy, carboxyamido, cyano, halo, hydroxyl, nitro, thio, C 1-6 alkyl, C 2-7 alkenyl, C 2-7 alkynyl, C 3-10 cycloalkyl, a 3-10 member heterocycloalkyl, C 6-10 aryl, a 5-10 member heteroaryl, alkoxy, aryloxy, sulfinyl, sulfonyl, oxo, guanidino and formyl; with the proviso that when W 1 , W 2 and W 3 are all —CH═C(CH 3 )—, X 1 , X 2 , X 3 , X 4 and X 5 are all H, and R 2 , R 3 and R 4 are all H, then R 1 is not H; with the proviso that in Formula Ib and Ic R 1 is H; or a pharmaceutically acceptable salt thereof.