Patent ID: 7576061

Claim:
A method of reducing the number of mitochondria undergoing mitochondrial permeability transitioning (MPT), or preventing mitochondrial permeability transitioning in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a peptide having the formula D-Arg-Dmt-Lys-Phe-NH 2 , D-Arg-Dmt-Phe-Lys-NH 2 , D-Arg-Phe-Lys-Dmt-NH 2 , D-Arg-Phe-Dmt-Lys-NH 2 , D-Arg-Lys-Dmt-Phe-NH 2 , D-Arg-Lys-Phe-Dmt-NH 2 , Phe-Lys-Dmt-D-Arg-NH 2 , Phe-Lys-D-Arg-Dmt-NH 2 , Phe-D-Arg-Dmt-Lys-NH 2 , Phe-D-Arg-Lys-Dmt-NH 2 , Phe-Dmt-D-Arg-Lys-NH 2 , Phe-Dmt-Lys-D-Arg-NH 2 , Lys-Phe-Dmt-D-Arg-NH 2 , Lys-Dmt-D-Arg-Phe-NH 2 , Lys-Dmt-Phe-D-Arg-NH 2 , Lys-D-Arg-Phe-Dmt-NH 2 , Lys-D-Arg-Dmt-Phe-NH 2 , D-Arg-Dmt-D-Arg-Phe-NH 2 , D-Arg-Dmt-D-Arg-Dmt-NH 2 , D-Arg-Dmt-D-Arg-Tyr-NH 2 , D-Arg-Dmt-D-Arg-Trp-NH 2 , Trp-D-Arg-Phe-Lys-NH 2 , Trp-D-Arg-Tyr-Lys-NH 2 , Trp-D-Arg-Trp-Lys-NH 2 , Trp-D-Arg-Dmt-Lys-NH 2 , D-Arg-Trp-Lys-Phe-NH 2 , D-Arg-Trp-Phe-Lys-NH 2 , D-Arg-Trp-Lys-Dmt-NH 2 , D-Arg-Trp-Dmt-Lys-NH 2 , D-Arg-Lys-Trp-Phe-NH 2 , D-Arg-Lys-Trp-Dmt-NH 2 , Cyclohexyl-D-Arg-Phe-Lys-NH 2 , or Ala-D-Arg-Phe-Lys-NH 2 .