Patent ID: 8445687

Claim:
A process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R′ is selected from the group consisting of —C(O)OA, —C(O)CX 3 , —C(O)NH 2 , —C(O)—NHOH or wherein A is alkyl or aryl and X is halogen, wherein compound (A) has formula (2) wherein A is alkyl or aryl, the process comprising condensing 4-(4-aminophenoxy)-N-methylpicolinamide or a salt thereof with carbamate derivative (2) to obtain sorafenib, wherein the carbamate derivative (2) is prepared by reacting 3-trifluoromethyl-4-chloroaniline with a haloformate (2a) or a carbonate derivative (2b) in the presence of a base and a solvent at a temperature ranging from −10° C. to 15° C., wherein in haloformate (2a), A is alkyl or aryl and X is halogen and in carbonate (2b), A is alkyl, aryl or the two A groups taken together form a 5 to 7 membered ring.