Patent ID: 7132425

Claim:
A compound according to formula I wherein R 1 is a lower alkyl having from 1 to 5 carbon atoms; R 2 is hydrogen, halo, nitro, cyano, methyl, trifluoromethyl, hydroxy, or methoxy; R 3 is cycloalkyl having from 4 to 6 carbons; Y is independently selected from the group of CH and N to form a pyridine or pyrazine ring, respectively; R 4 is a substituent in position 5 of the pyridine or pyrazine ring selected from the group consisting of: —(CH 2 ) n -Q, wherein Q is a 5-membered saturated, substituted, heterocyclic ring connected by a ring carbon atom, said heterocyclic ring containing two heteroatoms selected from nitrogen, sulfur and oxygen, and substituted at each of two ring carbons with an oxo group, and optionally substituted at the connecting ring carbon with a substituent which is methyl or amino; —(CH 2 ) n —V, wherein V is an unsubstituted or mono-substituted five- or six-membered saturated or unsaturated heterocyclic ring connected by a ring carbon, which said heterocyclic ring containing from one to three hetero atoms selected from sulfur, oxygen or nitrogen; said mono-substituted heterocyclic ring being a heterocyclic ring which is mono-substituted with a substituent selected from the group consisting of cyano, halo, nitro, amino, methyl, methoxy and hydroxy; a nine- or ten-membered bicyclic heterocyclic ring connected by a ring carbon atom, said bicyclic heterocyclic ring containing one hetero atom selected from the group consisting of oxygen, nitrogen or sulfur; and an unsubstituted or mono-substituted six-membered aryl ring connected by a ring carbon atom, said mono-substituted aryl ring being mono-substituted at a position on a ring carbon atom other than the connecting carbon atom with a substituent selected from the group consisting of cyano, halo, nitro, amino, methyl, methoxy, and hydroxy; R 5 is hydrogen or lower alkyl; R 6 is lower alkyl; R 7 is lower alkyl, cyano, or —C(═O)NH 2 ; R 8 is hydroxy, methoxy, or dimethylamine; R 9 is hydrogen or methyl; R 10 is lower alkyl, cyano, or —NH 2 ; R 11 is hydrogen, lower alkyl, or NHOH; m is 0, 1, 2, or 3; n is 0 or 1; p is 1 or 2; U is S, SO, or SO 2 ; Z is O, S, or NH; ----denotes an optional bond; * denotes an asymmetric carbon atom; or a pharmaceutically acceptable salt thereof.