Patent ID: 7425631

Claim:
A compound of formula II′ wherein the C ring is a 5 to 6-membered saturated carbocyclic moiety; wherein R′ is in the 1-position relative to the fused phenyl ring and is wherein R′ is phenyl or pyridinyl optionally substituted with one to five groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, haloalkoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ , and (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, each of which is optionally substituted with one to three groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; wherein R 2 is phenyl, benzothienyl or naphthyl optionally substituted with one to five groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , and (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl or heterocyclyl, each of which is optionally substituted with one to three groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; wherein R a is H; wherein R 4 and R 5 are hydrogen; wherein R 3 represents a basic moiety; and wherein R 8 and R 8′ independently are selected from H, and lower alkyl, aryl and heteroaryl, each of which is optionally substituted with one, two or three groups independently selected from lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, and trifluoromethyl; provided at least one of R 3 , R 4 and R 5 is a basic moiety; and pharmaceutically acceptable derivatives thereof.