Patent ID: 7507837

Claim:
A process for synthesizing site-selective coumarins at known locations of an electrode array device, comprising: (a) providing an electrode array device with a coating of the region above the electrodes with a porous polymer matrix having free amine groups; (b) coupling a substituted phenol substrate at selected electrodes of the electrode array device, wherein the substituted phenol substrate is selected from the group consisting of 2-,3-,4-, or 5-substituted amino-phenols, and combinations thereof, wherein the substitution is selected from the group consisting of C 1-6 alkyl, C 1-6 alkoxy, Cl, F, Br, hydroxy, aminoC 1-6 alkyl, and amino; and (c) performing a site selected Pd(II) catalysed cycloaddition reaction between the phenol substrate and an acetylene at selected electrode sites by providing a solution bathing the electrode array device, wherein the solution comprises a transition metal species and a confining agent, and biasing one or a plurality of selected electrodes on the electrode array device with a voltage or current to regenerate the transition metal species consumed during the cyclooxidation reaction.