Patent ID: 8436147

Claim:
A humanized monoclonal antibody that binds to STEAP-1, wherein the antibody comprises (a) heavy chain variable domain comprising: (1) an HC-FR1 comprising the amino acid sequence of SEQ ID NO:25; (2) an HVR-H1 comprising the amino acid sequence of SEQ ID NO:14; (3) an HC-FR2 comprising the amino acid sequence of SEQ ID NO:22; (4) an HVR-H2 comprising the amino acid sequence of SEQ ID NO:15; (5) an HC-FR3 comprising the amino acid sequence of SEQ ID NO:138; (6) an HVR-H3 comprising the amino acid sequence of SEQ ID NO:16; and (7) an HC-FR4 comprising the amino acid sequence of SEQ ID NO:24, and (b) a light chain variable domain comprising: (1) an HC-FR1 comprising the amino acid sequence of SEQ ID NO:17; (2) an HVR-H1 comprising the amino acid sequence of SEQ ID NO:11; (3) an HC-FR2 comprising the amino acid sequence of SEQ ID NO:18; (4) an HVR-H2 comprising the amino acid sequence of SEQ ID NO:12; (5) an HC-FR3 comprising the amino acid sequence of SEQ ID NO:19; (6) an HVR-H3 comprising the amino acid sequence of SEQ ID NO:13; and (7) an HC-FR4 comprising the amino acid sequence of SEQ ID NO:20, wherein the binding affinity to STEAP- 1 of said humanized antibody is higher than the binding affinity to STEAP-1 of a humanized antibody comprising a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO:9 and a light chain variable domain comprising the amino acid sequence of SEQ ID NO:6.