Patent ID: 7858105

Claim:
A method of reducing pigmentation of skin for cosmetic effects in a mammal comprising administering to the mammal an effective amount of a compound defined by structure (I), or a pharmaceutically acceptable salt or ester thereof: wherein: R 1 is H; R 2 is selenium; R″ is C or CH; when R″ is C, R′ is C(R8) 2 or NR3 and forms a bond with R″; when R″ is CH, R′ is CH 3 or NH 2 ; R 4 , R 5 , R 6 , and R 7 are independently CR 8 , or N; R 3 is (i) substituted or unsubstituted alkyl, alkenyl, aryl, or heterocycle, (ii) —C 1-5 alkoxy, (iii) —OH, (iv) hydrogen, (v) C(O)—C 1-3 alkyl, or (vi) —(CH 2 ) 1-5 SC(O)NR 9 R 10 ; R 8 is (i) hydrogen, (ii) halogen, (iii) NO 2 , (iv) —CN, (v) —OR 10 , (vi) —NHSO 2 —C 1-3 alkyl, (vii) —NHCO—C 1-5 alkyl, (viii) oxime, (ix) hydrazine, (x) —NR 9 R 10 , (xi) HSO 2 , (xii) HSO 3 , (xiii) thio-C 1-5 alkyl, (xiv) C 1-5 acyloxy, (xv) H 2 PO 3 , (xvi) thiol, (xvii) —COOR 9 , (xiii) C 1-5 alkynyl, or (xix) —C 1-5 alkyl, —C 1-5 alkenyl, aryl, heteroaryl, or heterocycle, optionally substituted with one or more of —OH, —SH, C(O)H, COOR 9 , C 1-5 acyloxy, halogen, NR 9 R 10 , C 1-5 thioether, or C 1-5 alkoxy; R 9 is hydrogen or C 1-3 alkyl; and R 10 is hydrogen, or C 1-5 alkyl optionally substituted with —OH.