Patent ID: 8563012

Claim:
A frozen particle composition, comprising: a frozen carbon dioxide particle approximately one micrometer or less, and defining at least one cavity; the at least one cavity containing at least one agent including a vitamin, vaccine or cytokine; and wherein the frozen carbon dioxide particle is coated with at least one biological remodeling agent including one or more of calcium phosphate, albumin, fibrin, thrombin, glutaraldehyde-crosslinked pericardium, hyaluronic acid, hydroxyapatite, keratin, ligament, nitinol, polyethylene, polylethylene glycol, polyethylene glycol diacrylate, polyethylene terephthalate fiber, polyglycol, polylactate, polytetrafluoroethylene, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, hyaluronic acid, agarose, cellulose, polyaldehyde gluronate, Factor XIII, Factor XII, silk, nylon, collagen, elastin, silicone, polyurethane, ceramic powder, pectin, wax, glycosaminoglycan, poly(α-hydroxyacid), selectin, or glutaraldehyde.