Patent ID: 7674814

Claim:
Process for the preparation of perindopril of the formula I or of pharmaceutically acceptable salts thereof characterized in that a salt of the acid chloride of the formula III is reacted with (2S,3aS,7aS)-octahydroindole-2-carboxylic acid of the formula IV wherein R represents a trimethylsilyl group and R1 represents hydrogen or a protecting group, such as the trimethylsilyl group, to form a compound of the formula V wherein R has the above meaning, which is converted to perindopril of the formula I by hydrolysis wherein the reaction for the formation of the peptide bond takes place in organic solvents, such as acetone, acetonitrile, dioxin, chloroform, methylene chloride, tetrahydrofuran or in a combination thereof with water, in the presence of a base.