Patent ID: 6962923

Claim:
A composition comprising a) a compound of formula (IA) or (IB) wherein R 1 is H, C 1-6 alkyl optionally substituted by one or more halo, OR 4 or NR 4 R 5 groups; C 2-6 alkenyl optionally substituted by one or more halo groups; C 2-6 alkynyl optionally substituted by one or more halo groups; C(O)R 4 ; CO 2 R 4 ; CH 2 aryl 4 ; CONR 4 R 5 ; or aryl 4 , R 2 is CH 2 CH 2 OG where G is CONHAr 2 or Ar 2 , R 4 and R 5 are each independently H or C 1-6 alkyl optionally substituted by one or more halo groups, X is a direct link, O, S, SO, SO 2 , CO or CH 2 , R 3 is a) a C 6-14 aromatic hydrocarbon group; or b) a pyridinyl ring; or c) CH 2 CH 2 Ph, or CH:CHPh; or d) C 1-6 alkyl, optionally substituted by 1-4 substituents selected from: halo, C 1-6 alkoxy, CO 2 R 4 , OC(O)R 4 and NR 4 R 5 ; each of which groups (a), (b) and (c) is optionally substituted by up to four substituents independently selected from i) C 1-6 alkyl, optionally substituted by 1-4 substituents selected from: halo, OR 4 , CO 2 R 4 , OC(O)R 4 and NR 4 R 5 ; ii) C 1-6 alkoxy; iii)CO 2 R 4 or OC(O)R 4 ; iv) Halo; v) NO 2 ; vi) CN; vii) NR 4 R 5 ; viii) C 1-3 alkylenedioxy; ix) OH; and x) Alkoxy carbonyl; Ar 1 is aryl 5 Ar 2 is het 1 “aryl 4 ” is a phenyl or naphthyl group optionally substituted by up to three substituents independently selected from C 1-3 alkyl, CF 3 , halogen, C 1-3 alkoxy, CF 3 O, OH, NO 2 , CN, NR 4 R 5 , COR 4 , CO 2 R 4 , CONR 4 R 5 , S(O) p (C 1-3 alkyl), CH 2 NR 4 R 5 , NR 4 COR 5 , COCF 3 , CH 2 OH, S(O) p CF 3 , and C(═NH)NH 2 , “aryl 5 ” is a phenyl, 1,3-benzodioxyl or naphthyl group optionally substituted by up to three substituents independently selected from C 1-3 alkyl, CF 3 , halogen, C 1-3 alkoxy, OCF 3 , OH, NO 2 , CN, NR 4 R 5 , C(O)R 4 , CO 2 R 4 , CONR 4 R 5 , S(O) p (C 1-3 alkyl), CH 2 NR 4 R 5 , NR 4 COR 5 , COCF 3 , CH 2 OH, S(O) p CF 3 , C(═NH)NH 2 , C 2-3 alkynyl, C 2-3 alkenyl, phenyl, “het 1 ” is pyrimidine-2-yl which is optionally substituted by up to three substituents independently selected from F, Cl, Br, CH 3 , NO 2 , CH 2 OH, C(O)H, NO 2 , NH 2 , SCH 3 , S(O)CH 3 , SO 2 CH 3 , furan-2-yl or thien-2-yl, and, when present in the “G” moiety, is linked to the O atom to which it is joined to the remainder of the compound of formula (IA) or (IB) via a carbon atom in said “het1” group, p is 0, 1 or 2, or a pharmaceutically acceptable salt thereof; and b) a pharmaceutically acceptable diluent or carrier.