Patent ID: 8034823

Claim:
A method of increasing the absorption and bioavailability of a pharmaceutical compound having an ionizable center capable of reacting with orotic acid, by converting said pharmaceutical compound to an orotate salt and, administering orally said orotate salt to a mammal to increase the absorption and bioavailability of said pharmaceutical compound, wherein said pharmaceutical compound is selected from the group of consisting of acetanilide, anilide, anthracycline antibiotic, benzodiazepine, cephalosporine, colchicines, cyclophosphamide, digitalis glycoside, dihydropyridine, epiphodophyllotoxin, epirubicin, ergot alkaloid, fluorouracil, macrolide, nitrogen mustard, phenothiazine, phenylpiperidine, pyrimidine, retinoid, sulfonylurea, tamoxifen, vinblastine or vinca alkaloid.