Patent ID: 8691869

Claim:
A gelatin capsule comprising a filling, the filling consisting essentially of: a) one or more NO-releasing NSAID(s) of formula (I) b) one or more surfactants wherein the ratio of surfactant to NO-releasing NSAID is from 0.1:1 to 10:1; c) a carbonyl scavenger compound selected from the group consisting of: free acid forms, salts, and carboxylic acid esters derivatives of a compound of formula (II) H 2 N—(CH 2 ) m —(C 6 H 4 )—COOH (II) wherein m=0-10, wherein the amount of the compound of formula (II) is from about 0.01% to about 5% by weight of the total weight of the composition; wherein in formula (I) M is selected from the group consisting of: X is a spacer selected from the group consisting of: i) straight or branched C 1 -C 20 alkylene being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO 2 and T, wherein T is —OC(O)(C 1 -C 10 alkyl)-ONO 2 or —O(C 1 -C 10 alkyl)-ONO 2 ; ii) C 5 -C 7 cycloalkylene group optionally substituted with linear or branched C 1 -C 10 alkyl group; iii) wherein n is an integer from 0 to 20; and n 1 is an integer from 1 to 20; wherein the —ONO 2 group of formula (I) is bound to —(CH 2 ) n 1 ; and iv) wherein X 2 is —O— or —S—; n 3 is an integer from 1 to 6, and R 2 is H or CH 3 .