Patent ID: 7728022

Claim:
A compound of formula I: wherein V represents a bond, CH 2 or CH 2 CH 2 ; X represents CR 1a or N; Y represents CO 2 H or tetrazole; Ar represents phenyl which optionally bears up to 3 substituents independently selected from hydrocarbon groups of up to 6 carbon atoms and (CH 2 ) m —Z where m is 0, 1 or 2 and Z represents halogen, N 3 , CN, CF 3 , OCF 3 , OR 4 , S(O) t R 4 where t is 0, 1 or 2, CO 2 R 4 , tetrazole, N(R 4 ) 2 , NHCOR 5 , NHCON(R 4 ) 2 , CON(R 4 ) 2 , SO 2 N(R 4 ) 2 , NHSO 2 R 5 , COR 5 , or OCOR 5 ; R 1 represents H or a nonaromatic hydrocarbon group of up to 10 carbon atoms optionally substituted with up to 3 halogen substituents or with CN, CF 3 , OR 4 , S(O) t R 4 where t is 0, 1 or 2, CO 2 R 4 , CON(R 4 ) 2 , SO 2 N(R 4 ) 2 , COR 4 , OCOR 5 or NR 4 COR 5 ; or R 1 represents phenyl, naphthyl, benzyl or heteroaryl any of which optionally bears up to 3 substituents selected from halogen, CF 3 , OCF 3 , CN, NO 2 R 5 , OR 4 , CO 2 R 4 , S(O) t R 4 where t is 0, 1 or 2, CON(R 4 ) 2 , SO 2 N(R 4 ) 2 , COR 4 , OCOR 5 or NR 4 COR 5 ; R 1a has the same definition as R 1 ; each R 2 is independently H or C 1-4 alkyl; R 3 is H or a hydrocarbon group containing up to 10 carbon atoms which is optionally substituted with halogen, CF 3 , C 1-4 alkoxy or C 1-4 alkylthio; R 4 represents H or a hydrocarbon group of up to 7 carbon atoms, optionally substituted with halogen, CN, CF 3 , OH, C 1-4 alkoxy or C 1-4 alkoxycarbonyl; or two R 4 groups attached to the same nitrogen atom may complete a 5- or 6-membered heterocyclic ring; R 5 represents R 4 that is other than H; p is 0, 1 or 2; and R 6 represents C 1-6 alkyl, C 2-6 alkenyl or phenyl, benzyl or heteroaryl, said phenyl, benzyl or heteroaryl optionally bearing up to 3 substituents selected from halogen, CN, CF 3 , OCF 3 , OR 4 , CO 2 R 4 , COR 4 , OCOR 5 and C 1-4 alkyl; or a pharmaceutically acceptable salt thereof.