Patent ID: 7579365

Claim:
A method of treating a disease selected from leukemia, prostate carcinoma, ovarian carcinoma, epidermal carcinoma, and dunning tumor, the method comprising administering to a subject in need thereof an effective amount of N-substituted indole-3-glyoxylamide of formula I or an acid addition salt thereof wherein the radicals R, R 1 , R 2 , R 3 , R 4 , and Z have the following meanings: R=hydrogen, (C 1 -C 6 )-alkyl, where the alkyl group is optionally mono- or polysubstituted by a phenyl ring and this phenyl ring is optionally substituted by one or more substituents selected from halogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, a carboxyl group, a carboxyl group esterified with a (C 1 -C 6 )-alkanol, a trifluoromethyl group, a hydroxyl group, a methoxy group, an ethoxy group, a benzyloxy group, or a benzyl group which is mono- or polysubstituted in the phenyl moiety by one or more substituents selected from (C 1 -C 6 )-alkyl group, a halogen, and a trifluoromethyl group, or R=a benzyloxycarbonyl group or a tertiary-butoxycarbonyl radical, or an acetyl group, R 1 =a pyridine structure of formula II or its N-oxide, where the pyridine structure is bonded at either the 2, 3, or 4 position of the ring and is optionally substituted by R 5 and R 6 ; wherein R 5 and R 6 are identical or different and are selected from (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkoxy, nitro, amino, hydroxyl, halogen, trifluoromethyl, ethoxycarbonylamino radical and a carboxyalkyloxy group in which the alkyl group has 1-4 C atoms; R 2 =hydrogen or (C 1 -C 6 )-alkyl, where the alkyl group is mono- or polysubstituted by halogen or phenyl, which is optionally substituted by one or more substituents selected from halogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, a carboxyl group, a carboxyl group esterified with a (C 1 -C 6 )-alkanol, a trifluoromethyl group, a hydroxyl group, a methoxy group, an ethoxy group or a benzyloxy group, wherein when R 2 is a (C 1 -C 6 )-alkyl group, it is optionally substituted by a 2-quinolyl group where the 2-, 3- and 4-pyridyl structure, is optionally mono- or polysubstituted by one or more substituents selected from halogen, (C 1 -C 4 )-alkyl groups or (C 1 -C 4 )-alkoxy groups, or R 2 is an aroyl radical, where the aryl moiety on which the radical is based is a phenyl ring, which is optionally mono- or polysubstituted by halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-cycloalkyl, a carboxyl group, a carboxyl groups esterified with a (C 1 -C 6 )-alkanol, trifluoromethyl group, a hydroxyl group, a methoxy group, an ethoxy group or a benzyloxy group; R 3 and R 4 are identical or different and are independently selected from hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkanoyl, (C 1 -C 6 )-alkoxy, halogen, benzyloxy, a nitro group, an amino group, a (C 1 -C 4 )-mono or dialkyl-substituted amino group, a (C 1 -C 6 ) alkoxycarbonylamino, and —(C 1 -C 6 )-alkoxycarbonylamino-(C 1 -C 6 )-alkyl; and Z is oxygen or sulfur.