Patent ID: 8334288

Claim:
A compound of Formula I: in which: R 1 is selected from phenyl, pyridin-2-yl, pyridin-3-yl, pyrimidin-5-yl, pyrazol-4-yl, 1H-pyrazol-4-yl, 6-oxo-1,6-dihydropyridin-3-yl, 2-oxo-1,2-dihydropyrimidin-5-yl, 2-oxo-1,2-dihydropyridin-4-yl and 2-oxo-2,3-dihydrooxazolo[4,5-b]pyridin-6-yl; wherein said phenyl, pyridin-2-yl, pyridin-3-yl, pyrimidin-5-yl, pyrazol-4-yl, 1H-pyrazol-4-yl, 6-oxo-1,6-dihydropyridin-3-yl, 2-oxo-1,2-dihydropyrimidin-5-yl, 2-oxo-1,2-dihydropyridin-4-yl or 2-oxo-2,3-dihydrooxazolo[4,5-b]pyridin-6-yl of R 1 is optionally substituted with 1 to 3 radicals independently selected from halo, —X 1 R 4 , —X 1 OR 4 , —X 1 C(O)R 4 , —X 1 C(O)OR 4 , —X 2 NR 4 C(O)R 4 , —X 1 S(O) 2 R 4 , —X 1 NR 4 S(O) 2 R 4 , —X 1 C(O)NR 4 R 5 , —X 1 C(O)NR 4 X 2 OR 5 , —X 1 C(O)NR 4 X 2 NR 4 R 5 , —X 1 C(O)NR 4 X 2 C(O)OR 5 , —X 1 S(O) 0-2 X 2 R 4 , —X 1 S(O) 0-2 X 2 OR 4 , —X 2 CN, —X 1 OX 2 R 4 , —X 1 NR 5 X 2 R 4 , —X 2 NR 4 R 5 , —X 1 S(O) 0-2 X 2 C(O)R 4 , —X 1 S(O) 0-2 X 2 C(O)OR 4 and —X 1 S(O) 0-2 NR 4 R 5 ; wherein X 1 is selected from a bond, O, and C 1-4 alkylene; R 5 is selected from hydrogen and C 1-6 alkyl; each X 2 is independently selected from a bond and C 1-4 alkylene; each R 4 is independently selected from hydrogen, C 1-6 alkyl, C 6-10 aryl, C 1-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-8 cycloalkyl and —X 3 C(O)OR 7 , —X 3 R 7 , —X 3 OR 7 , —X 3 NR 7 R 8 ; wherein said alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R 4 is optionally substituted with 1 to 3 radicals independently selected from hydroxy, halo, amino, cyano, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, C 6-10 aryl-C 1-4 alkoxy and —NR 7 C(O)R 8 ; X 3 is C 1-3 alkylene; and R 7 is selected from hydrogen, C 1-6 alkyl and C 3-8 heterocycloalkyl optionally substituted with C 1-6 alkyl; R 8 are independently selected from hydrogen and C 1-6 alkyl; and R 2 is selected from R 9 and —C(O)OR 9 ; wherein R 9 is selected from C 1-6 alkyl, C 6-10 aryl, C 1-10 heteroaryl, C 3-8 cycloalkyl and C 3-8 heterocycloalkyl; wherein said alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 9 is optionally substituted with 1 to 3 radicals independently selected from halo, C 1-6 alkyl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl, halo-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkyl, C 1-6 alkoxy and halo-substituted-C 1-6 alkoxy; or the pharmaceutically acceptable salts thereof.