Patent ID: 8586588

Claim:
A compound according to formula (Ia): or a stereoisomeric form, mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, wherein: Y is S(O) q or O or NR 15 ; R 1 is selected from a pyrrolidinyl or piperidinyl ring, optionally substituted with 1 to 3 R 20 groups; R 2 is each R 3 is independently H, F, Cl, Br, I, OR 21 , NR 23 R 24 , NO 2 , CN, CF 3 , C 1 -C 6 alkyl, C(═O)R 21 , CO 2 R 21 , or C(═O)NR 23 R 24 ; or when R 3 is ortho to R 2 , then R 3 and R 14 taken together may form —(CH 2 ) s —, —CH 2 Z—, —ZCH 2 —, —ZCH 2 CH 2 — or CH 2 CH 2 Z—; wherein Z is O or S(O) y ; or when R 3 is ortho to R 2 , then R 3 and R 13 taken together may form —(CH 2 ) s —, —CH 2 Z—, —ZCH 2 —, —ZCH 2 CH 2 — or CH 2 CH 2 Z—; each R 4 is independently H, C 1 -C 6 alkyl, or C 1 -C 6 alkoxyl, wherein the alkyl or alkoxyl group is optionally substituted with 1 to 3 R 20 groups; R 12 is H, C 1 -C 6 alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, C(═O)R 27 , or CO 2 R 27 , wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heterocycloalkyl group is optionally substituted with 1 to 3 R 20 groups; R 13 and R 14 are each independently H, C 1 -C 6 alkyl, aryl, arylalkyl C 1 -C 6 alkoxyl, S(═O) y —C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, or heteroaryl; R 15 is H, C 1 -C 6 alkyl, C(═O)R 25 , or CO 2 R 25 ; R 20 at each occurrence is independently, H, F, Cl, Br, I, OR 21 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 -C 6 alkyl optionally substituted with OR 26 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkylC 0 -C 4 alkyl, 3- to 7-membered heterocycloalkylC 0 -C 4 alkyl, phenyl, 5- or 6-membered heteroarylC 0 -C 4 alkyl, arylalkyl, (═O), C(═O)R 21 , CO 2 R 21 , OC(═O)R 21 , C(═O)NR 23 R 24 , NR 27 C(═O)R 21 , NR 27 C(═O)OR 21 , OC(═O)NR 23 R 24 , NR 27 C(═S)R 21 , or S(O) q R 21 ; each R 21 is independently H, C 1 -C 6 alkyl, aryl, or arylalkyl; each R 23 and R 24 is independently selected from H, C 1 -C 6 alkyl, and aryl, or R 23 and R 24 , together with the nitrogen atom to which they are attached, form a 3 to 7 membered heterocyclic ring optionally substituted with ═O; R 25 is C 1 -C 6 alkyl, aryl, or alkylaryl; R 26 is H, C 1 -C 6 alkyl, aryl, or alkylaryl; R 27 is H or C 1 -C 6 alkyl; m is 1, 2, 3, 4, or 5 when R 1 is attached via a nitrogen atom, and m is 0, 1, 2, 3, 4, or 5 when R 1 is attached via a carbon atom; n is 1 or 2; q is 0, 1, or 2; s is 1, 2, or 3; and y is 0, 1, or 2.