Patent ID: 8022176

Claim:
A Fas mimetic represented by the formula (I) wherein B 1 and B 9 are independently a peptide of 1-6 genetically encoded amino acids, at least one of which is a genetically encoded hydrophobic amino acid, or a genetically encoded aromatic amino acid, Z 2 is cysteine, that forms a covalent linkage with B 1 , X 3 or X 4 and Z 8 , Z 8 is cysteine, that forms a covalent linkage with B 9 , X 7 and Z 2 , X 3 is a genetically encoded hydrophilic amino acid or null, X 4 is aspartic acid or glutamic acid, X 5 is aspartic acid or glutamic acid, X 6 is selected from the group consisting of histidine, lysine, arginine, asparagine or glutamine, X 7 is a genetically encoded aromatic amino acid “ ” is a covalent linkage comprising an amide or a substituted amide thereof, and “ ” is a covalent linkage, or a pharmaceutically acceptable salt.