Patent ID: 8642612

Claim:
A pharmaceutical composition comprising a compound of formula (I): or a pharmaceutically acceptable tautomer, salt, or solvate thereof; and a pharmaceutically acceptable carrier or excipient; wherein, L is O, S, or NR 5 ; Het is heterocyclyl; each R 2 and R 4 , is independently H, halo, amino, N-alkyl amino, N,N-dialkyl amino, amido, nitro, cyano, hydroxyl, alkoxy, or an optionally substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, or C 2 -C 12 alkynyl, wherein the substituents are selected from the group consisting of hydroxyl, halo, amino, N-alkyl amino, N,N-dialkyl amino, —NH—C(O)—R 6 , —NH—C(O)—OR 6 , —O—C(O)—R 6 , —O—C(O)—OR 6 , nitro, and alkoxy; R 1 is halo, amino, N-alkyl amino, N,N-dialkyl amino, amido, nitro, cyano, hydroxyl, alkoxy, or an optionally substituted C 1 -C 12 alkyl, C 2 -C 12 alkenyl, or C 2 -C 12 alkynyl, wherein the substituents are selected from the group consisting of hydroxyl, halo, amino, N-alkyl amino, N,N-dialkyl amino, —NH—C(O)—R 6 , —NH—C(O)—OR 6 , —O—C(O)—R 6 , —O—C(O)—OR 6 , nitro, and alkoxy; R 3 is an optionally substituted C 2 -C 12 alkenyl, or C 2 -C 12 alkynyl, wherein the substituents are selected from the group consisting of hydroxyl, halo, amino, N-alkyl amino, N,N-dialkyl amino, —NH—C(O)—R 6 , —NH—C(O)—OR 6 , —O—C(O)—R 6 , —O—C(O)—OR 6 , nitro, and alkoxy; R 5 is H, or an optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; and R 6 is an optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, or heteroaryl.