Patent ID: 7807844

Claim:
A TGF-β gene expression inhibitor comprising a pyrrole-imidazole polyamide containing: an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im) and a γ-aminobutyrate unit, wherein said pyrrole-imidazole polyamide can be folded into a U-shaped conformation at the γ-aminobutyrate unit in a minor groove of a double helix region (hereinafter referred to as target region) which comprises all of the following base sequence from −557 to −536 (SEQ ID NO: 1) in a human transforming growth factor β1(hereinafter also referred to as hTGF-β1) promoter, and a complementary strand thereof: (SEQ ID NO: 1) TAAAGGAGAGCAATTCTTACAG wherein a Py/Im pair corresponds to a C-G base pair, an Im/Py pair corresponds to a G-C base pair, and a Py/Py pair corresponds to both an A-T base pair and a T-A base pair, wherein said pyrrole-imidazole polyamide is represented by the following formula: wherein the terminal carboxyl group of said pyrrole-imidazole polyamide optionally is an amide, wherein the optional amide is an amide of the compound represented by Formula 1 with N,N-dimethylaminopropylamine, and said pyrrole-imidazole polyamide is optionally bonded to fluorescein-isothiocyanate.