Patent ID: 6875791

Claim:
A compound having the Formula I-EMPS: or a pharmaceutically acceptable salt thereof, wherein; B is cyclopropyl; A is a single covalent bond; R 2 is optionally substituted 3-amino-5-carboxyphenyl; K is C(R 4a R 4b ) n wherein n is an integer selected from 1 through 4; R 4a and R 4b are independently selected from the group consisting of halo, hydrido, hydroxy, cyano, hydroxyalkyl, alkyl, alkenyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkenyl, heteroaryl, heteroaryalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, cyanoalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylsulfinyl, arylsulfinylalkyl, arylsulfonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, and aralkylsulfonylalkyl, or R 4a and R 4b , when bonded to the same carbon, are taken together to form a group selected from the group consisting of oxo, thiono, and a linear spacer moiety having from 2 through 7 contiguous atoms connected to form a ring selected from the group consisting of a cycloalkyl ring having 3 through 8 contiguous members, a cycloalkenyl ring having 5 through 8 contiguous members, and a heterocyclyl ring having 5 through 8 contiguous members; E 0 is C(O)N(R 7 ) wherein R 7 is hydrido, hydroxy, alkyl, acyl, aroyl, heteroaroyl, or alkoxyalkyl; Y 0 is wherein D 5 , D 6 , J 5 , and J 6 are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2 is independently selected from the group consisting of C, and N + , no more than one of D 5 , D 6 , J 5 , and J 6 is O, no more than one of D 5 , D 6 , J 5 , and J 6 is S, one of D 5 , D 6 , J 5 , and J 6 must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6 are O an S, no more than three of D 5 , D 6 , J 5 , and J 6 are N when K 2 is N + , and no more than four of D 5 , D 6 , J 5 , and J 6 are N when K 2 is carbon with the provisos that R 16 , R 17 , R 18 , and R 19 are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen and when Y 0 is phenyl, said phenyl attaches directly to the nitrogen of E 0 ; R 16 , R 17 , R 18 , and R 19 are independently selected from the group consisting of hydrido, methoxy, ethoxy, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, bromo, acetyl, trifluoroacetyl, methoxycarbonyl, ethoxycarbonyl, and cyano; Q b is C(NR 25 )NR 23 R 24 ; R 23 , R 24 , and R 25 are independently selected from the group consisting of hydrido, methyl, ethyl, hydroxy, methoxy, ethoxy, 2-aminoethyl, 2-(N-methylamino)ethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N,N-trimethylamino)ethyl, N-(2-hydroxyethyl)amino, N,N-bis-(2-hydroxyethyl)amino, N-(2-hydroxyethyl)-N-(2-aminoethyl)amino, N-methylamino, N,N-dimethylamino, and N,N,N-trimethylamino; and Q 3 is CH 2 .