Patent ID: 7998489

Claim:
A modified Clostridial toxin comprising: a) a protease-activated G protein-coupled receptor (PAR) ligand domain; b) a Clostridial toxin enzymatic domain; c) a Clostridial toxin translocation domain; and d) a non-Clostridial toxin binding domain, wherein the non-Clostridial binding domain binds to a target cell surface receptor system other than the one used by a Clostridial binding domain and allows subsequent passage of the modified Clostridial toxin into an endosome within the target cell; wherein the non-Clostridial toxin binding domain is selected from the group consisting of a Bradykinin, a Dynorphin, a β-endorphin, an Etorphine, an Endomorphin-1, an Endomorphin-2, a Leu-enkephalin, a Met-enkephalin, a Galanin, a Lofentanil or a Nociceptin.