Patent ID: 8377874

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt, or hydrate thereof, wherein: is selected from the group of rings consisting of: heterocyclic ring systems, wherein the points of attachment to variables Y and X are independently selected from a first pair of atoms comprising a first carbon ring atom and second carbon ring atom, and a second pair of atoms comprising a carbon ring atom and a nitrogen ring atom, and the heterocyclic ring system is selected from the group consisting of: a) an 8-, 9- or 10-membered saturated or unsaturated bicyclic ring with 1, 2, or 3 heteroatom ring atoms selected from the group consisting of N, O or S, and b) an 11- to 15-membered saturated or unsaturated tricyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, wherein said heterocyclic ring system is unsubstituted, mono-substituted with R 5 , or disubstituted with groups independently selected from R 5 ; R 1 is CO 2 R 10 or CONR 10 SO 2 R 6 ; R 5 is H, OR 10 , or aryl; wherein aryl is phenyl; R 6 is C 3 -C 6 cycloalkyl; Z is C 3-9 alkylene which is unsubstituted or substituted with 1, 2, or 3 substituents independently selected from —C 1-6 alkyl, where 2 of the substituents optionally form a spiro or fused ring contain the substituent atoms and shared atom or atoms; X is is —O or —C(O)O—, Y is selected from the group consisting of: 1) —C 1-7 alkylene-Y 1 —, and 2) —C 2-7 alkenylene-Y 1 —, wherein Y 1 is —OC(O)—, —NR 17 C(O)—, or —C(O)—, each alkylene, and alkenylene is unsubstituted or substituted with C 1-6 alkyl, any two adjacent carbon atoms in Y optionally form a C 3-6 membered ring containing 0 to 3 heteroatoms selected from the group consisting of N, O and S, and each alkylene, and alkenylene chain optionally includes an oxygen atom in place of a methylene moiety; each R 10 is independently H or C 1-6 alkyl; and R 17 is C 1-6 alkyl or a C 1-6 alkylene moiety that, together with another carbon atom in Y, forms a heterocyclic ring containing one nitrogen and 2-7 carbon atoms.