Patent ID: 7820790

Claim:
A polypeptide comprising a non-naturally-occurring monomer domain that selectively binds to IL-6, wherein the monomer domain is an LDL receptor class A monomer domain consisting of the following sequence CX 2 [A,P]X 4 [E,Q]FX 7 CX 9 X 10 GQC[I,L]PX 16 X 17 X 18 X 19 CDGX 23 [D,N]DCX 27 DX 29 SDEX 33 X 34 C (SEQ ID NO:3), wherein amino acids in brackets indicate alternative amino acids at a specified position; X 2 is L, V, Q or E; X 4 is D, G or S; X 7 is R or P; X 9 is G, D or E; X 10 is N or S; X 16 is L, A, Q or P; X 17 is D, H or P; X 18 is W or L; X 19 is V or G; X 23 is V or D; X 27 is G, A, V, E, P or R; X 29 is N, G or S; X 33 is T, A, E or K; and X 34 is G, S or D.