Patent ID: 8828355

Claim:
A method of visualizing a cell in a mammal-comprising: a) administering a binding domain ligand into the mammal wherein: (i) the binding domain ligand comprises; (1) a label, and (2) maltose, biotin, glutathione, or a hyaluran polymer; (ii) the cell comprises a visualization molecule, comprising; (1) a transmembrane domain, and (2) a secretory or plasma membrane trafficking signal domain selected from the group consisting of HLA-B7, PDGFR, EGFR, IGFR, and Ig-k; and (3) a hinge domain recognized by an endogenous protease selected from the group consisting of a complement protease or a serine protease, and (4) an extracellular binding domain, wherein the binding domain ligand interacts with the binding domain, and b) visualizing the label of the binding domain ligand.