Patent ID: 7056688

Claim:
A method for identifying a candidate drug which may alter low density lipoprotein (LDL) receptor function by altering an interaction of the LDL receptor with a native intracellular LDL receptor binding polypeptide, the method comprising steps: providing a system which comprises the binding polypeptide and a corresponding binding polypeptide interaction domain of the LDL receptor, introducing a test compound into the system and detecting a resultant level of binding between the binding polypeptide and the interaction domain, wherein a difference in the level of binding as compared to that of the system without the test compound indicates that the compound is a candidate drug, wherein the binding polypeptide is a c-Jun NH 2 -terminal kinase (JNK) interacting protein (JIP) selected from JIP1 (SEQ ID NO:11) and JIP2 (SEQ ID NO:31).