Patent ID: 7064136

Claim:
A compound having the formula wherein: R 1 is C 1-4 alkyl, substituted by 1 or 2 substituents selected from —NR a R a , —NR a C(═O)R a , —C(═O)NR a R a , —OR a , —OC(═O)R a , —C(═O)OR a , —S(═O) n C 1-6 alkyl, nitro, cyano and C 1-3 haloalkyl; phenyl substituted by 0, 1, 2 or 3 substituents selected from —NR a R a , —NR a C(═O)R a , —C(═O)NR a R a , —OR a , —OC(═O)R a , —C(═O)OR a , —S(═O) n C 1-6 alkyl, nitro, cyano and C 1-3 haloalkyl; or a 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms each independently selected from O, N and S and additionally having 0 or 1 oxo groups and 0 or 1 fused benzo rings; R 2 is H, halogen, —OR 9 or C 1-4 alkyl; R 3 is H, halogen, —OR 9 or —CN; R 4 is H, halogen, —OR 9 or C 1-4 alkyl; R 5 is H or CH 3 ; R 7 is phenyl substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, —NR a R a , —NR a C(═O)R a , —C(═O)NR a R a , —OR a , —OC(═O)R a , —C(═O)R a , —C(═O)OR a , —S(═O) n C 1-6 alkyl, nitro, cyano, C 1-3 haloalkyl, trifluoromethylthio, trifluoromethylsulfinyl, C 1-6 alkanesulfonamido, succinamido, carbamoyl, C 1-6 alkylcarbamoyl, di-C 1-6 alkylcarbamoyl, C 1-6 alkoxy-C 1-6 alkylcarbamoyl, ureido, C 1-6 alkylureido, di(C 1-6 alkyl)ureido, bromo, fluoro, chloro and dimethylcarbamoylmethylureido; or R 7 is a 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms each independently selected from O, N and S, said heterocycle additionally having 0 or 1 oxo groups and being substituted by 0 or 1 substituents selected from —OR a , —OC(═O)R a , —C(═O)OR a , —C(═O)R a , —NR a R a , —NR a C(═O)R a and —C(═O)NR a R a ; or R 7 is hydrogen or NR a R a ; R 8 is selected from hydrogen, —OR a , —OC(═O)R a , —C(═O)OR a , —C(═O)R a , —NR a R a , —NR a C(═O)R a , —C(═O)NR a R a , C 1-6 alkyl, carbamoyl, C 1-6 alkylcarbamoyl, and bis(C 1-6 alkyl)carbamoyl; R a is independently at each instance hydrogen or C 1-6 alkyl; R 9 is C 1-6 alkyl, phenyl or phenylC 1-6 alkyl; n is 0, 1 or 2; and X 1 and X 2 are independently H, —CH 3 or halogen; or any pharmaceutically-acceptable salt thereof.