Patent ID: 8518945

Claim:
A compound of Formula I wherein: Y is CH(R 1 ); R 1 is H or R 1a ; R 1a is lower alkyl, lower alkoxy, phenyl, benzyl, heteroaryl, cycloalkyl, heterocycloalkyl, or cycloalkylalkyl, optionally substituted with one or more R 1a′ ; R 1a′ is halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower hydroxyalkyl, oxo, hydroxy, or —CN; X is C(R 2 )(R 3 ), N(R 2 ), S(═O) 2 , or O; each R 2 is independently H or R 2a ; each R 2a is independently lower alkyl, lower haloalkyl, halogen, lower alkoxy, lower hydroxyalkyl, cyano, cyano lower alkyl, hydroxy, C(═O)R 2a′ or S(═O) 2 R 2a′ ; each R 2a′ is independently H or lower alkyl; each X′ is independently halogen, lower alkyl, cyano, hydroxy, lower haloalkyl, lower hydroxyalkyl, heteroaryl, spiroheterocycloalkyl, spirocycloalkyl, lower alkoxy, lower alkylamino, or lower dialkylamino; or X′ and R 2 come together to form a bicyclic ring system, optionally substituted with one or more R 2′ ; R 2′ is halogen, lower alkyl, lower alkoxy, hydroxy, lower hydroxyalkyl, lower haloalkyl, lower hydroxyalkylcyano, or —S(O) 2 CH 3 ; R 3 is H, hydroxy, halogen or lower alkyl; or R 2 and R 3 come together to form a spirocyclic ring system, optionally substituted with one or more R 2′ ; q is 0, 1, 2, 3, or 4; n is 0 or 1; p is 0 or 1; Q is H, halogen, hydroxy, cyano or Q′; Q′ is lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, cycloalkyl, cycloalkyloxy, phenyl, phenyloxy, cycloalkenyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q a ; Q a is Q b or Q c ; Q b is halogen, oxo, hydroxy, —CN, —SCH 3 , —S(O) 2 CH 3 , or —S(═O)CH 3 ; Q c is Q d or Q e′ ; or two Q a come together to form a bicyclic ring system, optionally substituted with one or more Q b or Q c ; Q d is —O(Q e ), —S(═O) 2 (Q e ), —C(═O)N(Q e ) 2 , —S(O) 2 (Q e ), —C(═O)(Q e ), —C(═O)O(Q e ), —N(Q e ) 2 ; —N(Q e )C(═O)(Q e ), —N(Q e )C(═O)O(Q e ), or —N(Q e )C(═O)N(Q e ) 2 ; each Q e is independently H or Q e′ ; each Q e ′ is independently lower alkyl, phenyl, benzyl, lower haloalkyl, lower alkoxy, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q f ; Q f is Q g or Q h ; Q g is halogen, hydroxy, cyano, oxo, or —C(═O)(Q h ); Q h is lower alkyl, lower haloalkyl, lower alkoxy, amino, phenyl, benzyl, cycloalkyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q i ; and Q i is halogen, hydroxy, cyano, lower alkyl, lower haloalkyl, or lower alkoxy; or a pharmaceutically acceptable salt thereof.