Patent ID: 6878733

Claim:
A formulation suitable for parenteral or oral administration, said formulation comprising an ionizable substituted indolinone of Formula (I): wherein R 1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, hydroxy, alkoxy, C-carboxy, O-carboxy, acetyl, C-amido, C-thioamido, sulfonyl and trihalomethanesulfonyl; R 2 is selected from the group consisting of hydrogen, halo, alkyl, cycloalkyl, aryl, heteroaryl and heteroalicyclic; R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N-sulfonamido, trihalomethane-sulfonamido, carbonyl, C-carboxy, O-carboxy, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, amino and —NR 11 R 12 ; R 11 and R 12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, carbonyl, acetyl, sulfonyl, trifluoromethanesulfonyl and, combined, a five- or six-member heteroalicyclic ring; R 3 and R 4 , R 4 and R 5 , or R 5 and R 6 may combine to form a six-member aryl ring, a methylenedioxy group or an ethylenedioxy group; R 7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, carbonyl, acetyl, C-amido, C-thioamido, amidino, C-carboxy, O-carboxy, sulfonyl and trihalomethane-sulfonyl; R 9 is -(alk 1 )Z, wherein Alk 1 is selected from the group consisting of alkyl, alkenyl or alkynyl, and Z is a polar group; R 8 and R 10 are independently selected from hydrogen and unsubstituted lower alkyl; one or more polyoxyhydrocarbyl compounds; and a pharmaceutically acceptable carrier therefor; wherein said ionizable substituted indolinone is solubilized by combining said indolinone with a molar equivalent of a base solution or an acid solution.