Patent ID: 8329751

Claim:
A compound of formula (I) wherein: R is a group of formula —Ar—X—Ar′ (II) wherein Ar is an arylene group and Ar′ is an aryl group; the said Ar and Ar′ being optionally substituted by one or more groups selected from: (i) straight or branched alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylamino, aminoacyl, acylamino or perfluorinated alkyl, each of which having from 1 to 4 carbon atoms in the alkyl chain; (ii) straight or branched C 2 -C 6 alkenyl or alkynyl group; and (iii) halogen or a cyano (—CN) group; X is a single bond or it is a divalent linker selected from a straight or branched C 1 -C 4 alkylene chain, —O—, —S—, —S(O) 2 —, —CO—, —NR′—, —NR′CO— and —CONR′—, wherein R′ is H or a straight or branched C 1 -C 4 alkyl group; R 1 is —OH or a group —ORa wherein Ra is selected from straight or branched C 1 -C 4 alkyl and C 2 -C 4 alkenyl groups; or Ra is a group of formula (III) —(CH 2 ) p —Z—(CH 2 ) r —W (III) wherein p is zero or an integer from 1 to 4; Z is a single bond or a divalent linker selected from —O—, —NR′—, —NR′CO— and —CONR′—, wherein R′ is as above defined; r is zero or an integer from 1 to 4; and W is phenyl or a 5 or 6 membered heterocycle, each of which being optionally substituted by one or more groups selected from —NH 2 , —COR′, —CONHR′, —COOR′, —SO 2 NHR′ wherein R′ is as above defined, aryl heteroaryl or by one or more of the above groups from (i) to (ii); One of R 2 and R 3 is H, and the other is a zinc binding group selected from —COOH, —COORb, —CONHOH, —CONHORb, —CONRbOH, —CONHS(O) 2 Rb, —CONH 2 , —CONHRb and —P(O)(OH) 2 , wherein Rb is a straight or branched alkyl, arylalkyl or heteroarylalkyl group having from 1 to 4 carbon atoms in the alkyl chain; or any of the above R 2 or R 3 groups is linked to R 1 so as to form a 5 to 7 membered heterocyclic ring at least comprising two adjacent N—O heteroatoms, optionally substituted by one or more oxo groups (═O); R 4 and R 5 together with the N atom to which they are bonded, form an optionally benzocondensed 4 to 6 membered heterocycle, optionally substituted by a group Ra as above defined and/or by one or more oxo (═O) groups; n is 1 or 2; m is an integer from 1 to 6; or a pharmaceutically acceptable salt thereof.