Patent ID: 6930114

Claim:
A compound of the formula (I) wherein x and y independently from each other denote zero or 1 with the proviso that x+y=1 or 2; R 1 and R 2 independently from each other denote hydrogen, C 1-4 -alkyl or CF 3 or R 1 and R 2 together form a C 1-4 -alkylene bridge; R 3 and R 4 independently from each other denote C 1-4 -alkyl; R 5 denotes C 6-14 -aryl, optionally having 1 to 3 further substituents selected from the group consisting of halogen; C 1-6 -alkyl which can be further substituted with one or more radicals selected from the group consisting of OH, halogen, NH 2 and C 1-6 -alkoxy; C 1-6 alkoxy which can be further substituted with one or more radicals selected from the group consisting of OH, halogen, NH 2 , C 1-6 -alkoxy and C 6-10 -aryloxy; OH; NO 2 ; CN; CF 3 ; OCF 3 ; NR 6 R 7 ; SR 8 ; —O—(CH 2 ) 1-4 —O— wherein the oxygen atoms are bound to the aryl moiety in ortho-position to each other; phenyloxy or benzyloxy wherein the phenyl moieties optionally contain one further substituent selected from the group consisting of C 1-6 -alkyl, C 1-6 -alkoxy, halogen, and NO 2 ; phenyl, optionally substituted with CN; and 4- to 9-membered heterocyclyl containing 1 to 4 hetero atoms selected from the group consisting of N, O, and S; R 6 and R 7 independently from each other denote hydrogen, C 1-6 -alkyl or, together with the nitrogen atom to which they are attached, form a 5- to 7-membered saturated, partially unsaturated or aromatic ring which can contain up to 3 further hetero atoms selected from the group consisting of N, O, and S, and which ring can contain 1 to 3 substituents selected from the group consisting of C 1-6 -alkyl, C 1-6 -alkoxy, C 6-10 -aryl and 4 to 9-membered aromatic heterocyclyl containing 1 to 4 hetero atoms selected from the group consisting of N, O, and S; and R 8 denotes hydrogen, C 1-6 -alkyl or C 6-10 -aryl-C 1-6 -alkyl with the proviso that 8,9-dimethoxy-3-methyl-2-phenyl-5,6-dihydro-pyrrolo-[2.1-a]isoquinoline-1-carboxylic acid ethyl ester is excluded, or an isomer, a pharmaceutically acceptable salt, a hydrate or a hydrate of a pharmaceutically acceptable salt thereof.