Patent ID: 7767832

Claim:
A method for separating an optically active thiophene-based compound, which comprises continuously separating a thiophene-based racemic mixture represented by the following Formula 1 into (S)-thiophene-based compound and (R)-thiophene-based compound, respectively, through optical resolution by a simulated moving bed (SMB) adsorption separation process in which an eluent is a mixture of acetonitrile and isopropanol, and an adsorbent comprises a support coated with a polysaccharide derivative: Wherein, X is S or SO 2 , Y is H, SO 3 H, or SO 2 NH 2 , and R is a linear or branched, saturated or unsaturated carbon chain having 1-20 carbons, a saturated or unsaturated carbon ring having 3-20 carbons, or a carbon chain or carbon ring containing a benzene ring having 6-20 carbons.