Patent ID: 7897633

Claim:
A compound of the formula 1 including all stereoisomers or pharmaceutically acceptable salts thereof: wherein: A is: an alkyl chain, an alkenyl chain, an alkynyl chain; or a group selected from formulae (I) to (V): wherein: R 6 , R 7 , R 8 , R 9 and R 10 are independently H or an alkyl chain, alkenyl chain, alkynyl chain, cycloalkyl, a carbocycle, aryl, heteroaryl, or a heterocycle; n and n 1 are independently 1-5; m is 1-5; o is 0-4; B is a group selected from formulae (VI), (VIa), (VIb), (VII), (VIII), and (IX): wherein: D and E independently represent an alkenyl chain, alkynyl chain, a cycloalkyl, carbocycle, aryl, -alkylaryl, heteroaryl, -alkylheteroaryl, acyl or a heterocycle; R 15 and R 16 are independently selected from the group consisting of H, a branched alkyl chain, an unbranched alkyl chain, a branched alkenyl chain, and an unbranched alkenyl chain; R 17 and R 18 are independently selected from the group consisting of H, an alkyl chain, an alkenyl chain, a alkynyl chain, a carbocycle, an aryl, a heteroaryl, and a heteroalkyl, or R 17 and R 18 can be connected to form a carbocycle with up to 6 ring atoms; Z is CH or N; X represents O or NR 19 ; R 19 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, -oxyalkyl, oxyaryl, carbonyl, amido hydroxy, NO 2 , NH 2 , and CN; and Y is O; with the provisos that: (i) If B is group (VI), then D is selected from the group consisting of 6-fluoro-4H-benzo[d][1,3]dioxin-8-yl, 3-(cyclopentyloxy)-4-(methoxy)-phenyl, 4-(heptyloxy)-phenyl, 4-(butoxy)-phenyl, 3,4-(dimethoxy)-phenyl, and 3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl; (ii) if X is NR 19 , then D is not acyl; (iii) if X is O, then -alkylheteroaryl is selected from the group consisting of pyridinylmethyl-, N-methyl-pyrrol-2-methyl-N-methyl-pyrrol-2-ethyl-, N-methyl-pyrrol-3-methyl-, N-methyl-pyrrol-3-ethyl-, 2-methyl-pyrrol-1-methyl-, 2-methyl-pyrrol-1-ethyl-, 3-methyl-pyrrol-1-methyl-, 3-methyl-pyrrol-1-ethyl-, 4-pyridino-methyl-, 4-pyridino-ethyl-, 2-(thiazol-2-yl)-ethyl-, tetrahydroisochinolinyl-methyl-, tetrahydroisochinolinyl-ethyl-, 2-ethyl-indol-1-methyl-, 2-ethyl-indol-1-ethyl-, 3-ethyl-indol-1-methyl-, 3-ethyl-indol-1-ethyl-, 4-methyl-pyridin-2-methyl-, 4-methyl-pyridin-2-yl-ethyl-, 4-methyl-pyridin-3-methyl, and 4-methyl-pyridin-3-ethyl; (iv) for formula (VII), if R 17 and R 18 form a carbocycle ring, then the carbocycle ring is not a 3 member carbocycle ring; (v) for formulas (VIII) and (IX), if Z═CH, then X is O; and with the proviso that the following compounds: are excluded from formula 1.