Patent ID: 7696177

Claim:
A compound of structural Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Ar 1 is selected from the group consisting of aryl and R 4 -substituted aryl; X, Y and Z are independently selected from the group consisting of —CH 2 —, —CH(C 1-6 alkyl)— and —C(C 1-6 alkyl) 2 —; R is selected from the group consisting of —OR 6 , —O(CO)R 6 , —O(CO)OR 8 , —O(CO)NR 6 R 7 , a sugar residue, a disugar residue, a trisugar residue and a tetrasugar residue; R 1 is selected from the group consisting of —H, —C 1-6 alkyl and aryl, or R and R 1 together are oxo; R 2 is selected from the group consisting of —OR 6 , —O(CO)R 6 , —O(CO)OR 8 and —O(CO)NR 6 R 7 ; R 3 is selected from the group consisting of —H, —C 1-6 alkyl and aryl or R 2 and R 3 together are oxo; q and r are integers each independently selected from 0 and 1 provided that at least one of q and r is 1; m, n and p are integers each independently selected from 0, 1, 2, 3 and 4, provided that the sum of m, n, p, q and r is 1, 2, 3, 4, 5 or 6; t is an integer selected from 0, 1 and 2; R 4 is 1-5 substituents independently selected at each occurrence from the group consisting of: —OR 5 , —O(CO)R 5 , —O(CO)OR 8 , —O—C 1-5 alkyl-OR 5 , —O(CO)NR 5 R 6 , —NR 5 R 6 , —NR 5 (CO)R 6 , —NR 5 (CO)OR 8 , —NR 5 (CO)NR 6 R 7 , —NR 5 SO 2 R 8 , —COOR 5 , —CONR 5 R 6 , —COR 5 , —SO 2 NR 5 R 6 , —S(O) t R 8 , —O—C 1-10 alkyl-COOR 5 , —O—C 1-10 alkyl-CONR 5 R 6 and fluoro; R 5 , R 6 and R 7 are independently selected at each occurrence from the group consisting of —H, —C 1-6 alkyl, aryl and aryl-substituted —C 1-6 alkyl; R 8 is independently selected from the group consisting of —C 1-6 alkyl, aryl and aryl-substituted —C 1-6 alkyl; R 9 is selected from the group consisting of —C≡C—(CH 2 ) y —NR 10 R 11 , —(CH 2 ) 2 —(CH 2 ) y NR 10 R 11 and —C≡C—C(O)R 16 ; R 10 is independently selected at each occurrence from —H and —C 1-3 alkyl; R 11 is selected from the group consisting of —H, —C 1-3 alkyl, —C(O)—C 1-3 alkyl, —C(O)—NR 10 R 10 , —SO 2 —C 1-3 alkyl, and —SO 2 -phenyl; and R 12 is selected from the group consisting of R 13 , —C 1-8 alkyl-R 13 , —CH═CH—(CH 2 ) w —R 13 and —C≡C—(CH 2 ) w —R 13 , provided that when R 12 is —C 1-8 alkyl-R 13 then R 9 is —(CH 2 ) 2 —(CH 2 ) y NR 10 R 11 ; w is an integer independently selected at each occurrence from 0, 1, 2, 3, 4, 5 and 6; y is an integer independently selected at each occurrence from 1, 2, 3, 4, 5 and 6; R 13 is R 14 is selected from the group consisting of —COOH, —COOC 1-6 alkyl, —CH 2 OH, —CH 2 O(CH 2 ) y —R 15 , —CONR 10 R 10 and R 15 is independently selected at each occurrence from the group consisting of —H, —OH, —COOR 10 , —NR 10 R 17 , —NR 10 COR 17 , —NR 10 COOR 17 , —NR 10 —SO 2 R 17 and —NR 10 —CONR 10 R 17 ; R 16 is selected from the group consisting of —OH, —OC 1-6 alkyl and —NR 10 R 11 ; and R 17 is selected from the group consisting of —H, —C 1-3 alkyl, phenyl and —CH 2 -phenyl.