Patent ID: 8143238

Claim:
A method of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient selected from the group consisting of: 2-methylene-19-nor-20(S)-1α-hydroxy-bishomopregnacalciferol according to the structure 19-nor-26,27-dimethylene-20(S)-2-methylene-1α,25-dihydroxyvitamin D 3 according to the structure 2-methylene-19-nor-(24R)-1α,25-dihydroxyvitamin D 2 according to the structure 2-methylene-1α,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D 3 according to the structure 2-methylene-(20R,25S)-19,26-dinor-1α,25-dihydroxyvitamin D 3 according to the structure 2-methylene-18,19-dinor-(20S)-1α,25-dihydroxyvitamin D 3 according to the structure 2-methylene-19-nor-1α-hydroxy-pregnacalciferol according to the structure 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol according to the structure (20R)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol according to the structure 2-methylene-(20S)-19-nor-1α-hydroxy-trishomopregnacalciferol according to the structure 2-methylene-(20R)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol according to the structure 2-methylene-(20S)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol according to the structure 2-(3′hydroxypropyl-1′,2′-idene)-19,23,24-trinor-(20S)-1α-hydroxyvitamin D 3 according to the structure 13,13-dimethyl-des-C,D analog of (20S)-2-methylene-1α,25-dihydroxy-19-nor-vitamin D 3 according to the structure or, a stereoisomer thereof.