Patent ID: 6846817

Claim:
A compound having the formula: wherein R 1 is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, NR a R b , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl, (C 3 -C 6 )cycloalkyl, or C(═O)NR a R b ; x is oxy, y is C 2 -C 3 alkyl chain substituted on the carbon adjacent x with —(CH 2 ) m R e , and optionally substituted on a carbon other than the carbon bearing —(CH 2 ) m R e with halo, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, NR a R b , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl, (C 3 -C 6 )cycloalkyl, or C(═O)NR a R b ; m is 0, 1, 2, 3, or 4; n is 1, 2, 3 or 4; each R a and R b is independently hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, aryl, or aryl(C 1 -C 6 )alkyl; or R a and R b together with the nitrogen to which they are attached form a 5-6 membered heterocyclic ring; and R e is a azetidinyl, pyrrolidinyl, 2-piperidinyl, morpholinyl, 1,2,3,4-tetrahydroisoquinolyl, 3,4,5,6-tetrahydropyridyl, or thiomorpholinyl wherein the ring R e is substituted on nitrogen with hydrogen, (C 1 -C 6 ) alkyl, or (C 1 -C 6 )alkanoyl and wherein any ring carbon of R e is optionally substituted with one or more R k ; each R k is independently halo, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, NR a R b , (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl, aryl(C 1 -C 6 )alkyl, aryl(C 2 -C 6 )alkenyl, aryl(C 2 -C 6 )alkynyl, aryl(C 1 -C 6 )alkoxy, aryl(C 1 -C 6 )alkanoyl, aryl(C 1 -C 6 )alkanoyloxy, aryl(C 1 -C 6 )alkoxycarbonyl, heteroaryl(C 1 -C 6 )alkyl, heteroaryl(C 2 -C 6 )alkenyl, heteroaryl(C 2 -C 6 )alkynyl, heteroaryl(C 1 -C 6 )alkoxy, heteroaryl(C 1 -C 6 )alkanoyl, heteroaryl(C 1 -C 6 )alkanoyloxy, heteroaryl(C 1 -C 6 )alkoxycarbonyl, (C 3 -C 6 )cycloalkyl, or C(═O)NR a R b ; wherein each aryl or heteroaryl is optionally substituted with one or more substituents independently selected from halo, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, NR a R b , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl, (C 3 -C 6 )cycloalkyl, or C(═O)NR a R b , or a pharmaceutically acceptable salt thereof; provided R 1 is not 6-hydroxy; when y is —(CH 2 ) 3 —; n is 1; and R e is 2-piperidinyl.