Patent ID: 8620420

Claim:
Method for filtering a signal of neuronal activity during a high frequency deep brain stimulation (DBS) to remove a stimulus artefact in an observed signal, comprising: using an analysis unit: i) approximating the observed signal trajectories in phase space, by considering the observed signal as a sum of the stimulation artefacts induced by the signal of stimulation, and by assuming that the signal of stimulation is a solution of an ordinary differential equation including a self-oscillating system with stable limit cycle, ii) slicing the observed signal and its derivative into segments, each segment corresponding to a period of stimulation, and selecting N periods among the segments, iii) collecting the N selected periods of stimulation into a training set, iv) estimating the limit cycle of the self-oscillating system using the training set, v) synchronizing each stimulation artefact of the observed signal with the estimated limit cycle, vi) subtracting the estimated limit cycle from each artefact in phase space according to the synchronization, vii) collecting all segments in order to obtain a whole filtered signal, and viii) presenting the results in the time domain.