Patent ID: 7524878

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein, R 1 is H, C 1 -C 6 alkyl, phenyl(C 1 -C 6 )alkyl, or C 2 - C 6 alkenyl; L 2 is a bond; L 3 is a bond, —(C 1 -C 4 )alkyl-O—, —O—(C 1 -C 4 )alkyl, —(C 1 -C 4 ) alkyl-, -alkenyl-, or -phenyl-; L 5 is —N(R 9 )C(O)—(C 1 -C 4 ) alkyl- or —N(R 9 )SO 2 —(C 1 -C 4 )alkyl-, wherein R 9 is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonyl, —SO 2 -aryl, heteroarylalkyl, or arylalkyl, wherein the aryl or heteroaryl groups are optionally substituted with 1, 2, 3, or 4 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, OH, NO 2 , NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, haloalkyl, or haloalkoxy; R 20 , R 21 , R 22 , and R 23 are independently selected from H, arylalkoxy, arylalkyl, halogen, alkyl, alkoxy, NO 2 , NH 2 , CN, NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl (C 1 -C 6 )alkyl, NH-aryl, NHC(O)—(C 1 -C 4 ) alkyl-aryl, N(C 1 -C 4 alkyl)C(O)—(C 1 -C 4 ) alkyl-aryl, N(C 1 -C 4 )alkyl-aryl, —NHSO 2 -aryl, and —N(C 1 -C 4 alkyl)SO 2 -aryl, wherein the aryl group is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, OH, NO 2 , haloalkyl, or haloalkoxy; the A ring is phenyl, which is optionally substituted with 1, 2, or 3 groups that are independently, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, NO 2 , NH 2 , NH(C 1 -C 6 )alkyl, or N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl; Q is aryl, aryl-carbonyl-aryl, -aryl-O-aryl, -aryl-alkyl-aryl, -aryl-heteroaryl, -aryl-heterocycloalkyl, heteroaryl, or -heteroaryl-alkyl-aryl, wherein the aforementioned cyclic groups are optionally substituted with 1, 2, 3, 4, or 5 groups that are independently alkoxycarbonyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, haloalkyl, haloalkoxy, NR 6 R 7 , phenyl, phenyl-C 1 -C 6 alkyl-, or phenyloxy-; wherein R 6 and R 7 are independently H, C 1 -C 6 alkyl, aryl(C 1 -C 6 )alkyl, C 2 -C 6 alkanoyl, aryl C 2 -C 6 alkanoyl, C 1 -C 6 alkoxycarbonyl, aryl C 1 -C 6 alkoxycarbonyl, heteroarylcarbonyl, heteroaryl, heterocycloalkylcarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, or —SO 2 -aryl, wherein the cyclic groups are optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, NO 2 , OH, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, haloalkyl or haloalkoxy; and Z is absent, H, —NHC(O)aryl, —N(C 1 -C 4 alkyl)C(O)aryl, or aryl, wherein the aryl groups are optionally substituted with 1, 2, 3, 4, or 5 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, haloalkyl, haloalkoxy, or NO 2 , or Z is —NHC(O)—(C 1 -C 4 )alkyl-(C 3 -C 7 )cycloalkyl, or —N(C 1 -C 4 )alkyl-C(O)—(C 1 -C 4 )alkyl-(C 3 -C 7 )cycloalkyl.