Patent ID: 7829665

Claim:
A compound having the Formula V: or a pharmaceutically acceptable salt, prodrug, or ester thereof wherein: R 1 is H, C 1-7 alkyl, C 3-7 cycloalkyl, pyridyl, thioazolo, naphthyl, fused heterocycle, phenyl, substituted phenyl, benzyloxy, or substituted benzyloxy; R 2 is H, C 1-6 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, phenyl, substituted phenyl, C 1-6 alkoxy, or substituted C 1-6 alkoxy; R 3 is H, C 1-6 alkyl, C(O)R 5 , C(O)OR 5 , C(O)NR 5 R 6 , C(S)NR 5 R 6 , or S(O) 2 R 5 ; R 5 and R 6 are each independently selected from H, C 1-6 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, C 3-7 cycloalkyl fused to C 6 aryl or C 6 aryl heterocyclyl, benzyl, phenyl, or substituted phenyl; Y is a sulfonimide of the formula —C(O)NHS(O) 2 R 4 or a carboxylic acid of the formula —C(O)OH, wherein R 4 is C 1-6 alkyl, C 3-7 cycloalkyl, C 4-10 cycloalkyl-alkyl, C 6 aryl, or substituted C 6 aryl; Z is a bond, O, or S; and the dashed line represents an optional double bond.