Patent ID: 7638509

Claim:
A compound having the structure or a pharmaceutically acceptable salt of the compound wherein, A is —CR 9 R 10 —; E is —C(O)— or —CR 5 R 6 —; G is ═CR 3 —; K is —CR 1 R 2 —; R and R′ independently are —F, —Cl, —Br, —I, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, —CN, —COOR 14 , —C(O)NR 14 R 15 , —NO 2 , —NR 14 R 15 , —NR 14 —C(O)—R 15 , —OH, substituted or unsubstituted lower alkoxy, and —S(O) 0-2 R 14 ; R 1 is —OR 11 , —C(O)—R 12 , —C(O)—NR 12 R 13 , —C(O)—OR 12 , —C(S)—R 12 , —C(S)—OR 12 or —S(O) 0-2 —R 12 ; R 2 is —H, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene or substituted or unsubstituted lower alkyne; R 3 and R 5 independently are —H, —F, —Cl, —Br, —I, substituted and unsubstituted lower alkyl, substituted and unsubstituted lower alkene, substituted and unsubstituted lower alkyne, —CN, —COOR 14 , —C(O)NR 14 R 15 , —NO 2 , —NR 14 R 15 , —NR 14 —C(O)—R 15 , —OH, substituted and unsubstituted lower alkoxy or —S(O) 0-2 R 14 ; R 6 is —H, —F, —Cl, —Br, —I, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, —CN, —COOR 14 , —C(O)NR 14 R 15 , —NO 2 , —NR 14 R 15 , —NR 14 —C(O)—R 15 , —OH, substituted and unsubstituted lower alkoxy or and —S(O) 0-2 R 14 ; R 7 and R 8 independently are —H or substituted or unsubstituted lower alkyl; R 9 is —OH or substituted or unsubstituted lower alkoxy; R 10 is substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, substituted or unsubstituted —S(O) 0-2 (lower alkyl), or R 9 and R 10 , together with the carbon to which they are attached, form a 5-, 6-, or 7-member heterocyclyl or cycloalkyl group; R 11 is —H, substituted or unsubstituted alkyl, substituted or unsubstituted alkene, substituted or unsubstituted alkyne, —C(O)—R 12 , —C(O)—NR 12 R 13 , —C(O)—R 12 , —C(S)—R 12 , —NR 12 R 13 , —S(O) 2 —R 12 , —S(O) 2 —OR 12 , and —P(O)(OR 12 )(OR 13 ) 0-1 ; R 12 and R 13 independently are —H, substituted or unsubstituted alkyl, substituted or unsubstituted alkene, substituted or unsubstituted alkyne, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclyl or substituted or unsubstituted heterocyclylalkyl; R 14 and R 15 independently are —H, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkene, substituted or unsubstituted lower alkyne, substituted or unsubstituted C 6-10 aryl, or substituted or unsubstituted C 7-12 arylalkyl; n is 0, 1, or 2; and n′ is 0, 1 or 2.