Patent ID: 7790904

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein: X is —O—, —S—, —S(O)—, —S(O 2 )—, or —C(R 11 R 12 )—C(O)O—; R 1 is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, heterocyclyl or heterocyclyl-lower-alkyl, wherein a lower-alkyl, cycloalkyl or heterocyclyl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy; R 2 is hydrogen or lower-alkyl; R 3 is cycloalkyl, cycloalkyl-lower-alkyl, heterocyclyl or heterocyclyl-lower-alkyl, wherein a cycloalkyl or heterocyclyl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy; R 4 is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, aryl, aryl-lower-alkyl, heteroaryl, heteroaryl-lower-alkyl, heterocyclyl or heterocyclyl-lower-alkyl, wherein a lower-alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, hydroxy, lower-alkyl, hydroxy-lower-alkyl, lower-alkyl-O-lower-alkyl-O-lower-alkyl, fluoro-lower-alkyl, lower-alkyl-carbonyl, lower-alkoxy, fluoro-lower-alkoxy and dioxo-lower-alkylene; R 5 , R 6 , R 7 and R 8 independently from each other are hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, cycloalkyl-oxy or heterocyclyl-oxy; R 9 and R 10 independently from each other are hydrogen or lower-alkyl, or R 9 and R 10 are bound together to form a cycloalkyl or heterocyclyl together with the carbon atom to which they are attached; R 11 and 12 independently from each other are hydrogen or lower-alkyl, or R 11 and R 12 are bound together, to form a cycloalkyl or heterocyclyl together with the carbon atom to which they are attached.