Patent ID: 7122559

Claim:
A compound according to formula (I), or a stereoisomer or a pharmaceutically-acceptable salt or hydrate thereof, wherein: X is —NR 6 S(O) p R 16 ; W is hydrogen or —(CR 7 R 8 ) q —W 1 ; W 1 is hydrogen or may be taken together with R 6 to define a bond so that X and W are joined together to form a five to seven membered heterocyclic ring; Z is isoquinolyl optionally substituted with 1–3 substituents selected from R 9 and/or R 10 ; R 1 , R 2 and R 3 are attached to any available carbon atom of the phenyl ring and are independently selected from hydrogen, halogen, cyano, nitro, C 1-10 alkyl, C 2-10 alkenyl, substituted C 1-10 alkyl, substituted C 2-10 alkenyl, —C(═O)NR 12 R 13 , —OR 12 , —CO 2 R 12 , —C(═O)R 12 , —SR 12 , —S(O) t R 15 , —NR 12 R 13 , —NR 12 SO 2 R 15 , —NR 14 SO 2 NR 12 R 13 , —NR 12 CO 2 R 13 , —NR 12 C(═O)R 13 , —NR 14 C(═O)NR 12 R 13 , —SO 2 NR 12 R 13 , aryl, heteroary, cycloalkyl, and heterocyclo; R 6 is hydrogen, C 1-4 alkyl, NH 2 , C 1-4 alkylamino, hydroxy, or C 1-4 alkoxy, or together with W 1 is a bond so that X and W join together to form a five to seven membered heterocyclic ring; R 7 and R 8 are independently selected from hydrogen, —OR 18 , —NR 18 R 19 , —NR 18 SO 2 R 20 , alkyl, alkenyl, substituted alkyl, substituted alkenyl, halogen, haloalkyl, haloalkoxy, cyano, nitro, alkylthio, —C(═O)H, acyl, —CO 2 H, alkoxycarbonyl, sulfonamido, sulfonyl, and phenyl in turn optionally substituted with 1–3 of halogen, cyano, haloalkyl, haloalkoxy, nitro, hydroxy, C 1-4 alkyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy, amino, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , and C 1-4 aminoalkyl; R 9 and R 10 are independently selected from hydrogen, halogen, alkyl, substituted alkyl, haloalkyl, haloalkoxy, cyano, nitro, —S(O) u R 21 , —NR 22 SO 2 R 21 , —C(═O)NR 22 R 23 , —OR 22 , —CO 2 R 22 , —C(═O)R 22 , —SR 22 , —NR 22 R 23 , —NR 22 CO 2 R 23 , —NR 22 C(═O)R 23 , —NR 22 C(═O)NR 23 R 24 , —SO 2 NR 22 R 23 , —NR 22 SO 2 NR 23 R 24 , —C(═NR 22 )NR 23 R 24 , five or six membered heterocyclo or heteroaryl, phenyl, and C 3-7 cycloalkyl; wherein when R 9 or R 10 is selected from heterocyclo, heteroaryl, phenyl, and C 3-7 cycloalkyl, each of said cyclic groups in turn is optionally substituted with up to three of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 hydroxyalkyl, C 1-4 aminoalkyl, halogen, hydroxy, haloalkyl, haloalkoxy, amino, C 1-4 alkylamino, and/or cyano; R 12 , R 13 , R 14 , R 18 , R 19 , R 22 R 23 , and R 24 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, and heterocyclo; R 15 , R 20 and R 21 are independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, and heterocyclo; R 16 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, or heterocyclo; p is 1 or 2; q is 1, 2 or 3; t is 1 or 2; and u is 1 or 2; provided that: R 1 , R 2 , and R 3 are not all simultaneously hydrogen.