Patent ID: 7423148

Claim:
A compound having the formula I: or a stereoisomer, tautomer, or pharmaceutically acceptable salt-thereof, wherein Y is selected from the group consisting of (1) substituted or unsubstituted aryl, (2) substituted or unsubstituted heterocyclyl, and (3) substituted or unsubstituted heteroaryl; X is selected from the group consisting of (1) —N(R 1x )—, (2) —(CH 2 ) m —C(R 2x , R 3x )—N(R 1x )—, (3) —O—, (4) —S—, (5) —SO—, (6) —SO 2 —, (7) —C(R 2X , R 3x )—, and (8) wherein R 1x , R 2x , and R 3x are selected from the group consisting of (a) H, (b) substituted or unsubstituted C 1 -C 6 -alkyl, (c) substituted or unsubstituted C 2 -C 6 -alkenyl, (d) substituted or unsubstituted C 2 -C 6 -alkynyl, (e) substituted or unsubstituted aryl, (f) substituted or unsubstituted heterocyclyl, (g) substituted or unsubstituted heteroaryl; and m is 0, 1, 2, 3, or 4; R 1 is selected from the group consisting of (1) H, (2) substituted or unsubstituted C 1 -C 6 -alky 1 , (3) —COOH, (4) halo, (5) —OR 1t , and (6) —NHR 1t , wherein R 1t is H or C 1 -C 6 -alkyl; R 2 is selected from the group consisting of (1) substituted or unsubstituted aryl, (2) substituted or unsubstituted heteroaryl, and W is selected from the group consisting of (1) —N(R lw , R 2w ), and (2) wherein R 1w and R 2W are selected from the group consisting of (a) substituted or unsubstituted aryl, (b) substituted or unsubstituted heterocyclyl, and (c) substituted or unsubstituted heteroaryl, Z is selected from the group consisting of (a) —O—, (b) —NR z —, (c) —S—, (d) —SO—, (e) —SO 2 —, and (f) —CH 2 —, wherein R z is H or substituted or unsubstituted alkyl group; and R 4w is selected from the group consisting of (a) H, (b) substituted or unsubstituted C 1 -C 6 -alkyl, (c) —COOR 5w , (d) —CONH 2 , (e) —OR 5w , and (f) —NHR 5w , wherein R 5w is H or C 1 -C 6 -alkyl; and r is 0, 1, or 2; with the proviso that when R 2 is phenyl independently substituted with one to five substituents selected from hydrogen, cycloalkyl, heterocycloalkyl, halo, nitro, amino, sulphonamido, or alkylsulphonylamino, R 1 is hydrogen, haloalkyl, alkyl, or halo, and X is NR 1x , then Y is substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.