Patent ID: 7763623

Claim:
A compound of Formula (I): or a pharmaceutically acceptable salt, ester, or tautomer thereof, wherein: R 1 is selected from the group consisting of H, alkyl, R 4 , haloalkyl, -alkylene-R 4 , -alkylene-R 5 , -alkylene-R 6 , alkenyl, alkynyl, and -alkylene-O-alkyl; R 2 and R 3 together with the carbon atom to which they are both attached, combine to form a monocyclic cycloalkyl, bicyclic cycloalkyl or monocyclic heterocycloalkyl ring, wherein said monocyclic cycloalkyl, bicyclic cycloalkyl or monocyclic heterocycloalkyl ring is unsubstituted or optionally and independently substituted with one or more X 5 groups, and wherein said monocyclic cycloalkyl ring may be fused to a benzene ring, an aromatic heterocycle or a non-aromatic heterocycle, and wherein the monocyclic cycloalkyl ring can form a spirocyclic compound with a second cycloalkyl ring or with a heterocycloalkyl ring, wherein the second cycloalkyl ring or the heterocycloalkyl ring is unsubstituted or independently substituted with one or more X 5 groups; R 4 is unsubstituted cycloalkyl or cycloalkyl substituted with one or more Xgroups; R 5 is unsubstituted aryl and aryl substituted with one or more X 2 groups; R 6 is selected from the group consisting of unsubstituted heteroaryl and heteroaryl substituted with one or more X 3 groups; R 7 is unsubstituted heterocycloalkyl and heterocycloalkyl substituted with one or more X 4 groups; R 8 is selected from the group consisting of H, alkyl, R 4 , R 5 , R 6 , R 7 , —C(O)-alkyl, —C(O)—R 5 ; each R 9 is independently selected from the group consisting of H, alkyl, R 4 , R 5 , R 6 , and R 7 ; R 10 is selected from the group consisting of R 9 , —C(O)-alkyl, and —C(O)—R 5 ; Y is —O— or —N(R 10 )—; each X 1 is independently selected from the group consisting of halogen, alkyl, —O-alkyl, —OH, haloalkyl, aryl, and alkynyl; each X 2 is independently selected from the group consisting of halogen, alkyl, —O-alkyl, —OH, haloalkyl, aryl, and alkynyl; each X 3 is independently selected from the group consisting of halogen, alkyl, and N-oxide; each X 4 is independently selected form the group consisting of alkyl, R 5 , —C(O)-alkyl, —C(O)—R 5 , —C(O)—O-alkyl, -alkylene-R 5 , R 4 , and —S(O 2 )-alkyl; and each X 5 is independently selected from the group consisting of alkyl, aryl, —C(O)-alkyl, heteroaryl, —C(O)—O-alkyl, —C(O)—R 5 , —S(O 2 )-alkyl, —C(O)—N(R 9 ) 2 , R 5 , R 6 , —C(O)—R 4 , —C(O)—O—R 4 , —S(O 2 )—R 4 , —S(O 2 )-alkylene-R 4 , —S(O 2 )-alkylene-R 5 , —N(R 9 )—C(O)—O-alkyl, —N(R 9 )—C(O)—O—R 4 , —N(R 9 )—C(O)—N(R 9 ) 2 and —N(R 9 ) 2 , wherein said aryl is unsubstituted or independently substituted with one or more substitutent selected from -alkylene-R 7 or X 2 , and said heteroaryl is unsubstituted or substituted with one or more X 3 groups.