Patent ID: 7439247

Claim:
A compound represented by formula I: wherein: A is N or CH; R 1 is hydrogen, alkyl or arylalkyl; R 2 is alkyl, heteroalkyl, (R 4 ) 2 NCO-alkylene-(where each R 4 is independently hydrogen or alkyl), cycloalkyl, heterocyclyl, aryl, or heteroaryl; X is O, NR 3 or S, wherein R 3 is hydrogen, alkyl or aryl; and Y is a bond, O, NR 5 , C(═O), CH(OR 5 ), CH(R 5 ), or S(O) n , wherein n is 0, 1, or 2; and R 5 is hydrogen or alkyl; and R is aryl or heteroaryl; wherein aryl and arylalkyl are each independently unsubstituted or substituted with 1, 2, or 3 substituents selected from the group alkyl, haloalkyl, halo, hydroxy, amino, haloalkoxy, cyano, nitro, heteroalkyl, methylenedioxy, ethylenedioxy, —Y′-aryl, —Y′-heteroaryl, —Y′-cycloalkyl, —Y′-heterocyclyl, —Y′—OR 6 , —Y′—NR 6 R 7 , —Y′C(O)—R 6 , —Y′S(O) 0-2 R 6 , —Y′—NH—S(O) 0-2 R 6 , —Y′—S(O) 2 NR 6 R 7 , —Y′—NH—C(O)NR 6 R 7 , where Y′ is a bond or C 1 -C 3 alkylene, R 6 and R 7 are each independently selected from hydrogen, alkyl, haloalkyl, hydroxy, alkoxy, aryl, heteroaryl, cycloalkyl, and heterocyclyl, with the proviso that when the substituent is —Y′S(O) 1-2 R 6 or —Y′—NH—S(O) 2 R 6 said R 6 is not hydrogen; heteroalkyl is alkyl unsubstituted or substituted with 1, 2, or 3 substituents selected from the group —OR 8 , —NR 9 R 10 , and S(O) n R 11 , R 8 , R 9 , and R 10 are each independently hydrogen, acyl, alkyl, cycloalkyl, or cycloalkylalkyl, or R 9 and R 10 together with the N to which they are bound form heterocyclyl or heteroaryl, and R 11 is hydrogen, acyl, alkyl, cycloalkyl, or cycloalkylalkyl when n is 0, and R 11 is alkyl, cycloalkyl, cycloalkylalkyl, amino, acylamino, monoalkylamino, or dialkylamino when n is 1 or 2; cycloalkyl is unsubstituted or substituted with 1, 2, or 3 substituents selected from the group alkyl, hydroxy, alkoxy, amino, monosubstituted amino, disubstituted amino, haloalkyl, halo, cyanoalkyl, oxo, heteroalkyl, heterocyclyl, hydroxyalkyl, and —(X′) m —C(O) R 12 , where X′ is O or NR 13 , m is 0 or 1, R 13 is hydrogen, alkyl, haloalkyl, amino, monosubstituted amino, disubstituted amino, hydroxy, alkoxy, alkyl or optionally substituted phenyl, and R 12 is H or alkyl; heterocyclyl is unsubstituted or substituted with 1, 2, or 3 substituents selected from the group alkyl, hydroxy, hydroxyalkyl, alkoxy, heteroalkyl, and haloalkyl, and 0-2 ring carbon atoms are substituted with oxo; heteroaryl is unsubstituted or substituted with 1 or 2 substituents selected from the group alkyl, haloalkyl, heteroalkyl, heterocyclyl, halo, nitro, cyano, carboxy, acyl, -(alkylene) m -COOR 14 , and -(alkylene) m -CONR 15 R 16 , where R 14 is hydrogen, alkyl, optionally substituted phenylalkyl, or optionally substituted heteroaralkyl, R 15 and R 16 are each independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, aryl, or R 15 and R 16 together with the nitrogen atom to which they are attached form heterocyclyl or heteroaryl; or a pharmaceutically acceptable salt thereof.