Patent ID: 8541581

Claim:
A compound of formula III: or a pharmaceutically acceptable salt, solvate or prodrug thereof, or mixture thereof, wherein: is selected from a single bond and a double bond; m is 1 when is a single bond; m is 0 when is a double bond; Z 1 is —OR 14 ; Z 2 is —OR 15 ; R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 12 and R 13 each independently is selected from H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 perhaloalkyl, —CN, —OR 16 , NR 17 R 18 , —C(O)R 19 , C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 8 is selected from C 2-6 alkenyl, C 2-6 alkynyl, —C(O)R 20 , —C(O)NR 22 R 23 , S(O) 2 R 24 , C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered cycloheteroalkyl, 5-10 membered heteroaryl, and —(CH 2 ) p —R 25 ; R 14 and R 15 , at each occurrence, each independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; R 16 , at each occurrence, each independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 17 and R 18 , at each occurrence, each independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(O)R 26 , —C(O)OR 27 , C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 19 , at each occurrence, each independently is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 20 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered cycloheteroalkyl, 5-10 membered heteroaryl, and —(CH 2 ) q —R 28 ; R 22 and R 23 each independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered cycloheteroalkyl, 5-10 membered heteroaryl, and —(CH 2 ) r —R 29 ; R 24 is selected from C 1-6 alkyl, C 2-6 alkenyl, alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered cycloheteroalkyl, 5-10 membered heteroaryl, and —(CH 2 ) t —R 30 ; R 25 is selected from C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 26 and R 27 each independently is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 28 , R 29 , and R 30 , at each occurrence, each independently is selected from —OR 31 , —NR 32 R 33 , C 3-10 carbocyclyl, C 6-10 aryl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; R 31 , R 32 and R 33 , at each occurrence, each independently is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocyclyl, C 6-10 aryl, C 7-12 aralkyl, 3-10 membered cycloheteroalkyl, and 5-10 membered heteroaryl; and p, q, r, and t, at each occurrence, each independently is selected from 1, 2, 3, 4, 5 and 6.