Patent ID: 7253194

Claim:
A compound of Formula (I): wherein X is selected from the group consisting of: CRR′CO 2 H, CRR′-tetrazolyl, CRR′SO 3 H, CRR′P(O)(OH) 2 , CRR′P(O)(OH)(OR″), CHRCH 2 CO 2 H, CHRCH 2 -tetrazolyl, CHRCH 2 SO 3 H, CHRCH 2 P(O)(OH) 2 , CHRCH 2 P(O)(OH)(OR″), OP(O)(OH)R′, NRSO 3 H, NRP(O)(OH) 2 , and NRP(O)(OH)(OR″) wherein R, R′ and R″ are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, optionally substituted arylalkyl, optionally substituted cycloalkylalkyl and optionally substituted heterocyclylalkyl, except that R″ is not hydrogen; Q is a group of formula (a) Y is a group of formula (i) —(CH 2 ) m -aa-(CH 2 ) n —B; and Z is a group of formula: (iii) —(CH 2 ) p -A-(CH 2 ) q -A′-(CH 2 ) r —B wherein m is 0 or 1, n, p, q and r are independently selected from 0 to 15; aa is an amino acid side chain residue, provided that the amino acid is not cysteine or homocysteine; A and A′ are independently selected from the group consisting of O, NH, NR, NHC(O), NRC(O), CH 2 , CHR, CHNH 2 , C(O), C(O)O, C(O)NH, OC(O), and CH═CH, wherein R is selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted cycloalkylalkyl and optionally substituted heterocyclylalkyl; and B is selected from the group consisting of, hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted aryloxy, optionally substituted heterocyclyloxy; optionally substituted cycloalkoxy, and CO 2 H; wherein m, n, p, q, r, aa, A, A′ and B are such that the longest continuous chain of atoms in a group of formula (i) or (iii) is from 5 to 15 atoms long; and provided that the optional substituents are not mercapto, alkylthio, benzylthio or acylthio; wherein the compound of formula (I) has an IC 50 activity for inhibition of human non-pancreatic sPLA 2 at a concentration of 50 μm or less, or salt or thereof.