Patent ID: 7691901

Claim:
A method of inhibiting or reducing an inflammatory response in a subject comprising administering to a subject in need thereof an effective amount of a pharmaceutically acceptable formulation comprising a synthetic carotenoid analog or a carotenoid derivative; wherein the carotenoid analog or derivative has the structure wherein each R 3 is independently hydrogen or methyl; where each Y is independently O or H 2 ; where each R is independently -alkyl-NR 2 3 + , -alkyl-NR 2 2 , -aryl-NR 2 3 + , -alkyl-CO 2 − , -aryl-CO 2 − , -alkyl-CO 2 R 6 , -alkyl-CO 2 R 7 , —OR 8 , -amino acid-NH 2 , -amino acid-NH 3 + , -phosphorylated amino acid-NH 3 + , polyethylene glycol, dextran, H, alkyl, aryl, -alkyl-O—PO 2 —O-alkyl-NR 2 3 + , where each R 2 is independently H, alkyl, or aryl; wherein R′ is -alkyl-O, alkyl, or aryl; wherein n is 1 to 9 wherein each R 5 is independently H; wherein R 6 is alkyl, —CH 2 —CH(OH)—CH 2 —O—PO 2 —O-alkyl-NR 2 3 + , and wherein R 7 is -alkyl-NR 2 3 + , -aryl-NR 2 3 + , -alkyl-CO 2 − , -aryl-CO 2 − , -amino acid-NH 3 + , -phosphorylated amino acid-NH 3 + , polyethylene glycol, dextran, H, alkyl, Group IA metal, or aryl; where each R 8 is independently -alkyl-NR 2 3 + , -alkyl-NR 2 2 , -aryl-NR 2 3 + , -alkyl-CO 2 − , -aryl-CO 2 − , -alkyl-CO 2 H, -alkyl-CO 2 R 6 , -alkyl-CO 2 R 7 , —OR 7 , -amino acid-NH 2 , -amino acid-NH 3 + , -phosphorylated amino acid-NH 3 + , polyethylene glycol, dextran, H, alkyl, or aryl; and wherein said effective amount is sufficient to reduce the amount of at least one eicosanoid resulting from 5-Lipoxygenase activity.