Patent ID: 7772427

Claim:
A method for the treatment of obsessive compulsive neurosis in a subject, comprising administering to said subject a therapeutically effective amount of a compound of the formula: wherein R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, or lower cycloalkyl lower alkyl, and R is unsubstituted or is substituted with at least one electron withdrawing group or electron donating group; R 1 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, heterocyclic lower alkyl, heterocyclic, lower alkyl heterocyclic, lower cycloalkyl, or lower cycloalkyl lower alkyl, each unsubstituted or substituted with an electron donating group or an electron withdrawing group; and R 2 and R 3 are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, halo, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, or Z—Y wherein R 2 and R 3 may be unsubstituted or substituted with at least one electron withdrawing group or electron donating group; Z is O, S, S(O) a , NR 4 , or PR 4 ; Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, lower alkynyl, heterocyclic, heterocyclic lower alkyl, and Y may be unsubstituted or substituted with an electron donating group or an electron withdrawing group, or ZY taken together is NR 4 NR 5 R 7 , NR 4 OR 5 , ONR 4 R 7 , OPR 4 R 5 , PR 4 OR 5 , SNR 4 R 7 , NR 4 SR 7 , SPR 4 R 5 , PR 4 SR 7 , NR 4 PR 5 R 6 , PR 4 NR 5 R 7 , R 4 , R 5 and R 6 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, wherein R 4 , R 5 and R 6 may be unsubstituted or substituted with an electron withdrawing group or an electron donating group; and R 7 is COOR 8 , COR 8 , hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl or lower alkynyl, which R 7 may be unsubstituted or substituted with an electron withdrawing group or electron donating group; R 8 is hydrogen, lower alkyl, or aryl lower alkyl, and the aryl or alkyl group may be unsubstituted or substituted with an electron withdrawing group or an electron donating group; n is 1; and a is 1-3; wherein heterocyclic contains from 3 up to 18 ring atoms and up to a total of 17 ring carbon atoms containing 1 to 4 hetero ring atoms selected from the group consisting of nitrogen, oxygen and sulfur and wherein the electron withdrawing group and electron donating group are selected from halo, nitro, carboxy, lower alkenyl, lower alkynyl, lower alkanoyl, formyl, carboxamido, aryl, quaternary ammonium, trifluoromethyl, aryl lower alkanoyl, lower carbalkoxy, hydroxy, lower alkoxy, lower alkyl, amino, lower alkylamino, di (loweralkyl) amino, aryloxy, mercapto, lower alkylthio, lower alkyldithio, heterocyclic, guanidino, amino lower alkyl, sulfonium salts, sulfonyl, sulfoxide, cyano and aryloyl.