Patent ID: 8309611

Claim:
A method for the treatment of lung cancer comprising administering to a subject a therapeutically effective amount of a cyclohexenone compound having the structure: wherein each of X and Y independently is oxygen, NR 5 or sulfur; R is a hydrogen or C(═O)C 1 -C 8 alkyl; each of R 1 , R 2 and R 3 independently is a hydrogen, methyl or (CH 2 ) m —CH 3 ; R 4 is NR 5 R 6 , OR 5 , OC(═O)R 7 , C(═O)OR 5 , C(═O)R 5 , C(═O)NR 5 R 6 , halogen, 5 or 6-membered lactone, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, aryl, glucosyl, wherein 5 or 6-membered lactone, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, aryl, and glucosyl are optionally substituted with one or more substituents selected from NR 5 R 6 , OR 5 , OC(═O)R 7 , C(═O)OR 5 , C(═O)R 5 , C(═O)NR 5 R 6 , C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, and C 1 -C 8 haloalkyl; each of R 5 and R 6 is independently a hydrogen or C 1 -C 8 alkyl; R 7 is a C 1 -C 8 alkyl, OR 5 or NR 5 R 6 ; m=1-12; and n=1-12; or a pharmaceutically acceptable salt, metabolite, solvate or prodrug thereof.