Patent ID: 7781174

Claim:
A method for assessing the tumoral state of renal cells in a human or non human biological sample comprising renal cells, wherein said biological sample is suspected of comprising renal tumoral cells, said method comprising the steps of: a. detecting and evaluating the expression level of Chromatin Assembly Factor-1 (CAF-1) p60, p150, or p60 and p150 subunits in said biological sample and in a control sample, wherein said control sample (i) comprises healthy renal cells from the same tissue type as said biological sample; (ii) comprises renal tumoral cells from the same tissue type as said biological sample and is characterized by histological grade, or (iii) comprises renal tumoral cells taken prior to treatment from the same tumor and same patient as said biological sample; b. comparing the CAF-1 subunit expression level in said biological sample with that of said control sample; and c. correlating (i) a higher CAF-1 subunit expression level in said biological sample as compared to that of said control sample with a higher proliferative state of the renal cells in said biological sample as compared to that of the renal cells in said control sample, or (ii) a lower CAF-1 subunit expression level in said biological sample as compared to that of said control sample with a lower proliferative state of the renal cells in said biological sample as compared to that of the renal cells in said control sample.