Patent ID: 8722079

Claim:
An implantable drug depot for reducing, preventing or treating dystonia and/or post-stroke spasticity in a patient in need of such treatment, the drug depot comprising at least one biodegradeable polymer and clonidine or a pharmaceutically acceptable salt thereof in an amount from about 0.1 wt. % to about 30 wt. % of the drug depot, wherein the drug depot has a surface that has an initial burst release of about 5 wt. % to about 35 wt. % of the clonidine or pharmaceutically acceptable salt thereof over a first period of between about 24 and 48 hours and is capable of releasing clonidine over a period of 5 to 135 days, the at least one biodegradable polymer comprising poly(D,L-lactide-co-caprolactone), poly(L-lactide-co-caprolactone), poly(D,L-lactide), or a combination thereof, the drug depot having an inherent viscosity of about 0.5 dL/g to about 0.7 dL/g, about 0.6 dL/g to about 0.8 dL/g, about 0.7 dL/g to about 0.9 dL/g, or about 0.8 dL/g to about 1.0 dL/g and the drug depot has a modulus of elasticity of about 1×10 4 to about 6×10 5 dynes/cm 2 .