Patent ID: 8025878

Claim:
An isolated antibody or fragment thereof being selective and having high affinity for human Aβ protofibrils, wherein the antibody or fragment in its six CDR regions comprises the following consensus sequences: VH-CDR1 SFGMH (SEQ ID NO: 1); VH-CDR2 YISSGSSTIYYGDTVKG (SEQ ID NO: 2); VH-CDR3 EGGYYYGRSYYTMDY (SEQ ID NO: 3); VL-CDR1 RSSQSIVHSNGNTYLE (SEQ ID NO: 4); VL-CDR2 KVSNRFS (SEQ ID NO: 5); and VL-CDR3 FQGSHVPPT (SEQ ID NO: 6).