Patent ID: 6914123

Claim:
An isolated trpzip peptide scaffold comprising a presented turn sequence flanked on one side by first flanking peptide and flanked on the other side by a second flanking peptide, wherein the first flanking peptide consists of an amino sequence WTW and the second flanking sequence consists of an amino acid sequence WTW; wherein each of the T residues in each flanking peptide can be substituted with valine or isoleucine, or if the T residue on the first flanking peptide is substituted with valine or isoleucine, then the T on the second flaking peptide is substituted with H, F, Y or W, or if the T residue on the second flaking peptide is substituted with valine or isoleucine, then the T on the second flanking peptide is substituted with H, F, Y or W; wherein each of the W residues of the first and second flanking peptides is at a non-hydrogen bonded position and wherein each W residue on one of the flanking peptides forms a cross peptide pair with a W residue on the other flanking peptide and the peptide scaffold lacks a disulfide bond and comprises no more than 20 amino acids.