Patent ID: 7208608

Claim:
A method of manufacturing an amorphous form of the hemi-calcium salt of (3R,5R) 7-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid of formula I the method comprising, extracting, with an ethylacetate, a water-containing solution of a sodium salt of (3R,5R) 7-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid, which is obtained by alkaline hydrolysis of a tert-butyl ester of formula II, wherein the water-containing solution also contains reaction by-products; reacting the resulting extract with an organic or inorganic calcium salt or hydroxide, optionally rinsing one or more times with water, and precipitating hemi-calcium salt of (3R,5R) 7-[3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid of formula I with a C5–C12 hydrocarbon.