Patent ID: 8822460

Claim:
A compound of Formula (I): wherein: A is O, or S; R 0 is H, or C (1-4) alkyl; wherein said C (1-4) alkyl is optionally substituted with OH, C (1-4) alkyl-(OCH 2 CH 2 ) n —OCH 3 , OCH 3 , CO 2 H, C(O)NH 2 , SO 2 NH 2 , or CO 2 C (1-4) alkyl; n is 1, 2, or 3; R 1 is cyclohexyl, or tetrahydropyranyl; wherein said cyclohexyl or tetrahydropyranyl may be optionally substituted with one substituent selected from the group consisting of: OCH 3 , OH, CH 2 CH 3 , —CN, NH 2 , NH(CH 3 ), N(CH 3 ) 2 , or OCF 3 ; alternatively, R 0 and R 1 are taken together with their attached nitrogen to form a ring selected from the group consisting of R a is phenyl; wherein the phenyl is optionally substituted with C(O)NH 2 , C(O)NHC (1-4) alkyl, SO 2 NH 2 , C(O)N(C (1-4) alkyl) 2 , OCH 3 , CO 2 CH 3 , or CO 2 H; R b is C (1-4) alkyl, or OC (1-4) alkyl; R 2 is selected from the group consisting of H, C (1-4) alkyl, cyclopropyl, cyclohexyl, phenyl, pyridyl, pyrimidyl, pyrazyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, furyl, and thiophenyl; wherein said phenyl, pyridyl, pyrimidyl, pyrazyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, furyl, or thiophenyl is optionally substituted with one substituent selected from the group consisting of NH 2 , NHC (1-3) alkyl, N(C (1-3) alkyl) 2 , C (1-3) alkyl, —CN, —CH═CH 2 , —CONH 2 , —CO 2 H, —NO 2 , —CONHC (1-4) alkyl, CON(C (1-4) alkyl) 2 , C (1-4) alkylCONH 2 , —NHCOC (1-4) alkyl, —CO 2 C (1-4) alkyl, CF 3 , SO 2 C (1-4) alkyl, —SO 2 NH 2 , —SO 2 NH(C (1-4) alkyl), and —SO 2 N(C (1-4) alkyl) 2 ; R 3 is H, or CH 3 ; alternatively, R 3 and R 2 are taken together with their attached carbon to form R 4 is R 5 is H, or CH 3 ; alternatively, R 4 and R 5 are taken together with their attached nitrogen to form a ring selected from the group consisting of: R 6 is CF 3 , or OCF 3 ; R 7 is a CF 3 substituted heteroaryl, provided that R 7 is not R x is CF 3 , F, Cl, CN, or OCH 3 ; R y is H, F, Cl, or CF 3 ; R z is H, or F; or a pharmaceutically acceptable salt thereof.