Patent ID: 7495001

Claim:
A Compound of the formula and enantiomers and pharmaceutically acceptable salts and esters thereof, wherein X 1 is O or CH 2 ; R 1 is hydrogen or C 1-7 -alkyl; R 2 is hydrogen or C 1-7 -alkyl, or, if X 1 is CH 2 , R 2 is hydrogen, C 1-7 -alkyl or C 1-7 -alkoxy; R 3 is hydrogen or C 1-7 -alkyl; R 4 and R 5 or R 5 and R 6 are bonded to each other to form a ring together with the carbon atoms to which they are attached, and R 4 and R 5 or R 5 and R 6 together are: —CH═CH—CH═CH— or —(CH 2 ) p , wherein p is 4; and R 4 and R 6 are engaged in a ring structure as defined above or independently from each other are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 -alkyl, cyano-C 1-7 -alkyl or cyano; R 7 and R 8 independently from each other are selected from the group consisting of hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, halogen, C 1-7 -alkoxy-C 1-7 -alkyl, C 2-7 -alkenyl, C 2-7 -alkinyl, fluoro-C 1-7 -alkyl, cyano-C 1-7 -alkyl or cyano; and one of R 6 and R 7 is wherein X 2 is O or NR 9 ; R 9 is hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, fluoro-C 1-7 -alkyl, hydroxy-C 2-7 -alkyl, or C 1-7 -alkoxy-C 2-7 -alkyl; Y 1 is N and Y 2 , Y 3 and Y 4 are C—R 12 or Y 1 and Y 4 are N and Y 2 and Y 3 are C—R 12 ; R 10 is hydrogen, C 1-7 -alkyl, C 3-7 -cycloalkyl, or fluoro-C 1-7 -alkyl; R 11 is hydrogen, C 1-7 -alkyl, or C 1-7 -alkoxy-C 1-7 -alkyl; R 12 independently from each other in each occurrence is selected from the group consisting of hydrogen, C 1-7 -alkyl and C 3-7 -cycloalkyl; R 13 is aryl or heteroaryl; and n is 0, 1 or 2; provided that compounds of formula I are excluded, wherein X 1 is O, R 2 and R 3 are hydrogen, R 6 is equal to X 2 is O and R 10 and R 11 are hydrogen.