Patent ID: 7514573

Claim:
A process for the manufacture of 3-(S)-aminotetrahydrofuran comprising the steps of a) reduction of a compound with structure I to a compound with structure II with the aid of a hydride reducing agent; wherein R 1 is selected from the group consisting of C 1 -C 6 straight chain and branched alkyls and —CH 2 -Aryl; R 2 is selected from a group consisting of C 1 -C 6 straight chain and branched alkyls, —CH 2 -Aryl, phenyl and substituted phenyl; b) cyclizing the compound with structure II with the aid of sulfonic acids to structure III; c) hydrolyzing the compound using a base with structure III to 3-(S)-aminotetrahydrofuran; and d) recovering 3-(S)-aminotetrahydrofuran as its hydrochloride or p-toluenesulfonate salt or as base itself.