Patent ID: 8293234

Claim:
An isolated inhibitory antibody against factor VIII or a fragment thereof comprising the immunoglobulin variable light chain CDR1, CDR2, and CDR3 regions depicted in SEQ ID NO:36, SEQ ID NO:37, and SEQ ID NO:38 respectively, and comprising the immunoglobulin variable heavy chain CDR1, CDR2, and CDR3 regions depicted in SEQ ID NO:33, SEQ ID NO:34, and SEQ ID NO:35 respectively, wherein the glycosylation of said antibody or fragment thereof on the glycosylation site at amino acid positions 3 to 5 of the CDR1 region of the variable heavy chain is decreased relative to the glycosylation of the same antibody as produced by the EBV-immortalized human B cell line KRIX1 deposited with the Belgian Coordinated Collections of Micro-organisms under accession number LMBP 5089CB.