Patent ID: 7825263

Claim:
A compound of general formula A-(Y—ONO 2 ) s (I) and the enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof, wherein s is an integer equal to 1; A is selected from the following β-adrenergic blockers residues of formula (II): wherein R 1 is R 2 is Z is —C(O)—; Z 1 is H; Y is a bivalent radical selected from the group consisting of: a) straight or branched C 1 -C 20 alkylene being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO 2 or T, wherein T is —OC(O)(C 1 -C 10 alkyl)-ONO 2 , —O(C 1 -C 10 alkyl)-ONO 2 ; b) wherein: n is an integer from 0 to 20, n1 is an integer from 1 to 20; n2, n3, n4 and n5 are integers equal or different from each other, equal to 0 or 1, R 3 and R 4 are independently selected from H or CH 3 , Y 1 is —CH 2 — or —(CH 2 ) na —CH═CH— wherein na is an integer from 0 to 20; X 1 is —WC(O)— or —C(O)W—, wherein W is oxygen, sulfur or NH; and c) wherein X 2 is O or S, n10a, n10 and n12 are integer independently selected from 0 to 20, n11 is an integer from 0 to 6; R 11 is H, CH 3 or nitrooxy group; R 11a is CH 3 or nitrooxy group; and wherein (Y—ONO 2 ) s bonds with Z of formula (II).