Patent ID: 6902738

Claim:
A topical oral dosage form selected from the group consisting of chewing gums, lozenges, troches, and combinations thereof, wherein the topical oral dosage form comprises a pharmaceutically active agent effective against bacteria in an oral cavity which causes halitosis, wherein the pharmaceutically active agent comprises a bismuth compound selected from the group consisting of colloidal bismuth subcitrate, bismuth subcitrate, bismuth citrate, bismuth salicylate, bismuth subsalicylate, bismuth subnitrate, bismuth subcarbonate, bismuth tartrate, bismuth subgallate, tripotassium dicitrato bismuthate, bismuth aluminate, bismuth polysulfates, bismuth polyhydroxy compounds, alpha-D-glucopyranoside bismuth complex, beta-D-fructofuranosyl-oktakis (hydrogen sulfate) bismuth complex, L-dihydro ascorbyl-tetrakis (hydrogen sulfate) bismuth complex, bismuth ascorbyl sulfate, bismuth subascorbate, bismuth sucrose sulfate, bismuth cyclodextrin sulfate, and combinations thereof, and wherein the topical oral dosage form provides controlled release of the bismuth compound into saliva in the oral cavity for at least 5 minutes in a concentration in the saliva of at least 2 μg/mL.