Patent ID: 8420620

Claim:
A hetero-bifunctional ligand for use in inducing internalization of a target receptor, comprising: a target receptor-binding agent that specifically binds the target receptor on a cell, wherein the target receptor-binding agent is polyguanosine or oligodeoxyguanosine and the target receptor is neuropilin-1; a heterologous internalizing receptor-binding agent that specifically binds to an internalizing receptor on the same cell, wherein the internalizing receptor-binding agent is Fucoidan or sulfated dextran and the internalizing receptor is a scavenger receptor; and a linker linking the target receptor-binding agent to the internalizing receptor-binding agent, wherein the linker has a length sufficient to allow the hetero-bifunctional ligand to bind to the target receptor and the internalizing receptor on the same cell, wherein binding of the hetero-bifunctional ligand to the internalizing receptor and the target receptor induces internalization of both the internalizing receptor and the target receptor on the same cell.