Patent ID: 8513219

Claim:
A method of decreasing amyloid aggregates comprising contacting the amyloid aggregates with a compound of formula Ib, wherein: Z is O, S or NR 1 ; X is O, S or NR 1 ; R 1 is a hydrogen, a linear or branched C 1-40 alkyl, C 2-40 alkenyl, C 2-40 alkynyl, aryl, heteroaryl, C 1-40 alkylaryl or alkylheteroaryl; R is hydrogen or a substituted or unsubstituted linear or branched C 1-40 alkyl, aryl or heteroaryl; R 7 represents one or more ring substituents chosen from a hydrogen, a halide, a linear or branched C 1-40 alkyl, a C 2-40 alkenyl, a C 2-40 alkynyl, an aryl, a heteroaryl, a C 1-40 alkylaryl or alkylheteroaryl, a nitrile, a sulphonic acid or salt of sulphonic acid, a carboxy, an oxo, a carboxyalkyl, a carboxyalkoxy, a carboxyalkylamino, a carboxyalkylthio, an amide, a sulphonamide, a C 1-6 alkylalkoxy, C 1-6 alkylamino, OR 2 , SR 2 , NR 3 , and R 4 ; A and B are each, independently, OR 2 , SR 2 , NR 3 , or R 4 ; R 2 , R 3 and R 4 are each, independently, hydrogen, a linear or branched C 1-40 alkyl, C 2-40 alkenyl, C 2-40 alkynyl, C 1-40 alkylaryl, or optionally a complex metal ion M n+ /n wherein n is an integer from 1 to 8, or a linear or branched C 1-40 NR 5 R 6 terminated alkyl chain; D is hydrogen, a linear or branched C 1-40 alkyl, C 2-40 alkenyl, C 2-40 alkynyl, an aryl, a heteroaryl or C 1-40 alkylaryl or alkylheteroaryl or a linear or branched C 1-40 alkyl NR 5 R 6 chain or a linear or branched C 1-40 mono or di alkyl ester or dialkyl ester C 1-40 alkylphosphonate or a linear or branched C 1-40 alkylphosphonic acid; and R 5 and R 6 are each, independently, hydrogen or a linear or branched C 1-40 alkyl.