Patent ID: 7652062

Claim:
A method of treating benign and malignant breast neoplastic disease, adenocarcinomas or estrogen related breast carcinomas, said method comprising administering, said method comprising administering to a female of child-bearing age, a compound having the structure of formula I, or a pharmaceutically acceptable salt thereof: wherein: R 1 is selected from the group consisting of: H, CN, C(O)—C 1 -C 6 alkyl, C(O)—C 3 -C 8 cycloalkyl, C(O)-substituted C 1 -C 6 alkyl, C(O)-aryl, C(O)-substituted aryl, C(O)-heteroaryl, C(O)-heterocycle, C(O)—C 3 -C 6 alkenyl, C(O)—C 3 -C 6 alkynyl, C(O)-substituted C 3 -C 6 alkenyl, C(O)-substituted C 3 -C 6 alkynyl, C(O)O—C 1 -C 6 alkyl, C(O)O—C 3 -C 8 cycloalkyl, C(O)O-substituted C 1 -C 6 alkyl, C(O)O-aryl, C(O)O-substituted aryl, C(O)O-heteroaryl, C(O)O-heterocycle, C(O)O—C 3 -C 6 alkenyl, C(O)O—C 3 -C 6 alkynyl, C(O)O—C 3 -C 6 substituted alkenyl, C(O)O—C 3 -C 6 substituted alkynyl, C(O)NH—C 1 -C 6 alkyl, C(O)NH—C 3 -C 8 cycloalkyl, C(O)N-di-C 3 -C 8 cycloalkyl, C(O)N-di C 1 -C 6 alkyl, C(O)N-di-substituted C 1 -C 6 alkyl, C(O)NH-substituted C 1 -C 6 alkyl, C(O)NH-aryl, C(O)N-di-aryl, C(O)NH-substituted aryl, C(O)N-di-substituted aryl, C(O)NH-heteroaryl, C(O)N-di-heteroaryl, C(O)NH-heterocycle, C(O)N-di-heterocycle, C(O)NH—C 3 -C 6 alkenyl, C(O)NH—C 3 -C 6 alkynyl, C(O)NH-substituted C 3 -C 6 alkenyl, and C(O)NH-substituted C 3 -C 6 alkynyl; or R 1 is a linking group to a second structure of formula I to form a dimer of formula I, said linking group is a C(O)— group; R 2 is selected from the group consisting of H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, and C 3 -C 6 cycloalkyl; provided that both R 1 and R 2 are not H; provided that where R 1 is C(O) substituted aryl, R 2 is not H; provided that when R 1 is H and R 7 is H, R 2 is not C 1 -C 6 alkyl; R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of H, halogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, O—C 1 -C 6 alkyl, O—C 1 -C 6 substituted alkyl, aryl, heteroaryl, heterocycle, substituted aryl, substituted heteroaryl, and substituted heterocycle; and R 7 is selected from the group consisting of H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, and substituted C 3 -C 6 cycloalkyl.