Patent ID: 7074813

Claim:
A compound having the formula V: or a pharmaceutically acceptable salt thereof, wherein: Ar 3 is optionally substituted aryl; R 1 and R 2 are independently hydrogen, alkyl or cycloalkyl; R 3 â€“R 10 are independently hydrogen, halo, haloalkyl, aryl, fused aryl, carbocyclic, alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, carbocycloalkyl, hydroxyalkyl, nitro, amino, cyano, acylamino, hydroxy, thiol, sulfonyl, phosphonyl, acyloxy, azido, alkoxy, aryloxy, arylalkoxy, haloalkoxy, carboxy, carbonylamido or alkylthiol; with the proviso that when Ar 3 is unsubstituted phenyl then each of R 3 â€“R 7 is other than NH 2 , NHCH 3 , NO 2 , halo or CF 3 and at least one of R 3 â€“R 7 is other than hydrogen; wherein the alkyl, alkoxy, alkenyl and alkynyl groups may have optional substituents selected from the group consisting of one or more halo, hydroxy, carboxyl, amino, nitro, cyano, C 1 â€“C 6 acylamino, C 1 â€“C 6 acyloxy, C 1 â€“C 6 alkoxy, aryloxy, alkylthio, C 6 â€“C 10 aryl, C 4 â€“C 7 cycloalkyl, C 2 â€“C 6 alkenyl, C 2 â€“C 6 alkynyl, C 6 â€“C 10 aryl(C 2 â€“C 6 )alkenyl and C 6 â€“C 10 aryl(C 2 â€“C 6 )alkynyl groups; and wherein the aryl, aralkyl, aralkenyl and aralkynyl groups may have optional substituents selected from the group consisting of one or more halo, C 1 â€“C 6 haloalkyl, C 6 â€“C 10 aryl, C 6 â€“C 10 aryloxy, C 4 â€“C 7 cycloalkyl, C 1 â€“C 6 alkyl, C 2 â€“C 6 alkenyl, C 2 â€“C 6 alkynyl, C 6 â€“C 10 aryl(C 1 â€“C 6 )alkyl, C 6 â€“C 10 aryl(C 2 â€“C 6 )alkenyl-, C 6 â€“C 10 aryl(C 2 â€“C 6 )alkynyl, C 1 â€“C 6 hydroxyalkyl, nitro, amino, ureido, cyano, C 1 â€“C 6 acylamino, hydroxy, thiol, C 1 â€“C 6 acyloxy, azido, C 1 â€“C 6 alkoxy and carboxy groups.