Patent ID: 8771685

Claim:
An anti-Bv8 antibody comprising a variable domain comprising the following six hypervariable region (HVR) sequences: (i) HVR-L1 comprising KASQSX 1 X 2 YX 3 X 4 X 5 SYMN, wherein X 1 is L or V; X 2 is D; X 3 is S or Y; X 4 is G or H; and X 5 is D or Y; (ii) HVR-L2 comprising AASX 1 X 2 EX 3 , wherein X 1 is N; X 2 is L or R; and X 3 is S; (iii) HVR-L3 comprising QQINEDPFT; (iv) HVR-H1 comprising GYX 1 X 2 X 3 X 4 YDMH, wherein X 1 is S; X 2 is F or L; X 3 is T; X 4 is D or N; (v) HVR-H2 comprising YIX 1 X 2 YX 3 GX 4 TX 5 YNQKFKG, wherein X 1 is H or S; X 2 is S; X 3 is S; X 4 is A or S; X 5 is L or T, and (vi) HVR-H3 comprising DX 1 NYGEAYAMDY, wherein X 1 is S, or an antigen-binding fragment thereof.