Patent ID: 8278329

Claim:
A compound of formula (1), or a pharmaceutically acceptable salt thereof: wherein A represents —CH═CH—; a, b, c and d are each selected from the group consisting of CR 1 and CR 2 ; R 1 , R 2 and R 4 each independently represent H, a halogen, —CF 3 , —OR 14 , —COR 14 , —SR 14 , —S(O) t R 15 , —N(R 14 ) 2 , —NO 2 , —OC(O)R 14 , —CO 2 R 14 , —OCO 2 R 14 , —CN, —NR 14 COOR 15 , —SR 15 C(O)OR 15 or —SR 15 N(R 16 ) 2 wherein R 14 represents H, a lower alkyl, an aryl or an aryl-lower alkyl group, R 15 represents a lower alkyl or an aryl group, R 16 is independently selected from the group consisting of H and —C(O)OR 15 , and t represents 1 or 2; R 3 represents H; V—W represents C═C; n represents 2 or 3; R 5 and R 6 each independently represent H, a halogen, —CF 3 , a lower alkyl or an aryl; or R 5 and R 6 together form ═O or ═S; Y 1 represents O or S; B represents NR 17a , —NR 17a (CH 2 ) v CHR 21 —, —(CH 2 ) v CHR 21 — wherein v represents 0 to 3, R 17a represents H, a lower alkyl or an aryl, R 21 represents H, a lower alkyl, an aryl, a hydroxyl-lower alkyl, —CH 2 SH, —CH 2 CH 2 SCH 3 , —CH 2 (CO)NH 2 , —CH 2 CH 2 (CO)NH 2 , —(CH 2 ) w —COOR 29 , —(CH 2 ) w —NR 29 R 30 wherein R 29 and R 30 each independently represent hydrogen atom or a lower alkyl group, and w represents 0 to 4, —(CH 2 ) 3 NHC(NH 2 )═NH, benzyl, 4-hydroxybenzyl, 3-indoylmethyl or 5-imidazoylmethyl; G represents —(CO)—, —(SO)—, —(SO 2 )—or a covalent bond; m represents 0 to 6; R 7 and R 8 each independently represent H, a lower alkyl, an aryl, —(CO)R 18a , —(CS)R 18a , —(CO)NR 18a R 19a , —(CS)NR 18a R 19a wherein R 18a represents H, a lower alkyl, an aryl or a cycloalkyl group which may have a hetero atom in the ring, R 19a represents H, a lower alkyl or an aryl; or R 18a and R 19a together form a cycloalkyl which may have a halogen, —CF 3 , a lower alkyl or an aryl as a substituent, —(CO)OR 20 or —(CS)OR 20 wherein R 20 represents an alkyl group having 1 to 12 carbon atoms, an aryl group or a cycloalkyl group which may have a hetero atom in the ring, or a group of formula (5): wherein Y 4 and Y 3 each represent O or S; s represents 0 to 6; E represents NR 22 or CHR 23 wherein R 22 represents H, a lower alkyl or aryl; and R 23 represents H, a lower alkyl, an aryl, a hydroxyl-lower alkyl, —CH 2 SH, —CH 2 CH 2 SCH 3 , —CH 2 (CO)NH 2 , —CH 2 CH 2 (CO)NH 2 , —CH 2 COOH, —CH 2 CH 2 COOH, —(CH 2 ) 4 NH 2 , —(CH 2 ) 3 NHC(NH 2 )═NH, benzyl, 4-hydroxybenzyl, 3-indoylmethyl or 5-imidazoylmethyl; R 24 represents H, a lower alkyl or an aryl; R 25 represents H, a lower alkyl, an aryl, —OR 18a , —(CO)R 18a , —(CS)R 18a , —(CO)NR 18a R 19a , —(CS)NR 18a R 19a , —(CO)OR 20 or —(CS)OR 20 wherein R 18a , R 19a and R 20 are as defined above.