Patent ID: 7479575

Claim:
A process for the preparation of compounds of formula (I): wherein R is C 1 -C 12 -alkyl, C 1 -C 12 -alkyl aryl, C 1 -C 12 -alkyl heteroaryl, C 2 -C 12 -alkenyl, C 2 -C 12 -alkenyl aryl, C 2 -C 12 -alkenyl heteroaryl, C 2 -C 12 -alkynyl, C 2 -C 12 -alkynyl aryl, C 2 -C 12 -alkynyl heteroaryl, C 1 -C 12 -alkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl, C 1 -C 12 -alkoxy, aryl, heteroaryl, or a halide; said process comprising the steps of: Step 1: reacting an acyl chloride of formula (III) with an alkyl benzene of formula (IV) to yield the corresponding compound (V): wherein LG is a leaving group; Step 2: transforming a compound of formula (V) into compound of formula (VI), using a suitable halogenating agent: Step 3: subjecting a compound (VI) to an elimination reaction to provide a compound of formula (VII): Step 4: subjecting a compound of formula (VII) or an activated species thereof with a formylating agent (VIII) for giving the compound (I):