Patent ID: 6878724

Claim:
Polyarylcarboxamide compounds of formula (I): the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z 1 is (CH 2 ) n wherein n is 2; Z 2 is (CH 2 ) m wherein m is 2; X 1 represents O, CH 2 , CO, NH, CH 2 O, OCH 2 , CH 2 S, SCH 2 or a direct bond; X 2 a sp 2 carbon atom and X 3 is N; R 1 is hydrogen or C 1-4 alkyl; Ar 1 is phenyl, optionally substituted with one or two R 3 substituents; Ar 2 is an aromatic ring selected from phenyl, naphthalenyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, triazolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, furanyl and thienyl, optionally substituted with one, two or three R 4 substituents; each R 2 and R 3 is independently selected from C 1-4 alkyl, C 1-4 alkyloxy, halo and trifluoromethyl; each R 4 is independently selected from C 1-4 alkyl, C 1-4 alkyloxy, halo, hydroxy, mercapto, cyano, nitro, C 1-4 alkylthio or polyhaloC 1-6 alkyl, amino, C 1-4 alkylamino and di(C 1-4 alkyl)amino; p 1 and p 2 are each 0 to 2; p 3 is 0 to 3; X 1 and R 4 taken together with the aromatic rings Ar 1 and Ar 2 to which they are attached may form a fluoren-1-yl or a fluoren-4-yl group; A represents a C 1-6 alkanediyl substituted with one or two groups selected from aryl, heteroaryl and C 3-10 cycloalkyl; B represents hydrogen; C 1-10 alkyl; aryl or heteroaryl each optionally substituted with a group selected from halo, cyano, nitro, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkoxycarbonyl, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-6 alkyl; heteroarylC 1-10 alkyl; C 3-10 cycloalkyl; polyhaloC 1-6 alkyl; C 3-6 alkenyl; C 3-6 alkynyl; NR 6 R 7 ; or OR 8 ; R 6 and R 7 each independently represent hydrogen, C 1-10 alkyl, aryl or heteroaryl each optionally substituted with a group selected from halo, cyano, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl, heteroarylC 1-10 alkyl, C 3-10 cycloalkyl, C 7-10 polycycloalkyl, polyhaloC 1-6 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, fused benzo-C 5-8 cycloalkyl, and wherein R 6 and R 7 taken together with the nitrogen atom to which they are attached may form a C 4-8 saturated heterocyclic radical; R 8 represents C 1-10 alkyl, aryl or heteroaryl each optionally substituted with a group selected from halo, cyano, nitro, C 1-4 alkyloxy, amino, C 1-10 alkylamino, di(C 1-10 alkyl)amino, C 1-10 acyl, C 1-10 alkylthio, C 1-10 alkylaminocarbonyl and di(C 1-10 alkyl)aminocarbonyl; arylC 1-10 alkyl; heteroarylC 1-10 alkyl; and C 3-10 cycloalkyl; C 7-10 polycycloalkyl; polyhaloC 1-6 alkyl; C 3-8 alkenyl; C 3-8 alkynyl; or fused benzo-C 5-8 cycloalkyl.