Patent ID: 8779157

Claim:
A compound having a structure represented by a formula: wherein A is selected from O or S; wherein R 1 is pyridine, pyrimidine, thiazole, furan, thiophene, or pyrazine, optionally substituted with one or more R 8 , aryl, or a 3-8 membered ring containing C, O, S or N, optionally substituted with one or more R 8 ; wherein R 4 is selected from H, C 1-6 alkyl, C 3-10 cycloalkyl, aryl, heteroaryl optionally substituted with one or more R 7 ; wherein R 4 and R 5 may cyclize to form a 3-8 membered ring containing C, O, S or N, optionally substituted with one or more R 8 ; wherein R 5 is selected from: H, C 1-6 alkyl, C 3-10 cycloalkyl, aryl, heteroaryl optionally substituted with one or more R 8 ; wherein R 5 and R 6 may cyclize to form a 3-7 membered ring containing C, O, S or N, optionally substituted with one or more R 8 ; wherein R 6 is selected from: H, C 1-6 alkyl, C 3-10 cycloalkyl, aryl, heteroaryl optionally substituted with one or more R 8 , R 5 and R 6 may cyclize to form a 3-7 membered ring containing C, O, S or N, optionally substituted with one or more R 7 ; wherein R 7 is selected from: H, halogen, C 1-6 alkyl, C 3-10 cycloalkyl, OC 1-6 alkyl , aryl, heteroaryl, CN or CF 3 ; and wherein R 8 is selected from OH, NR 1 R 2 , halogen, C 1-6 alkyl, C 3-10 cycloalkyl, CN, OC 1-6 alkyl, CF 3 , or a pharmaceutically acceptable salt thereof.