Patent ID: 8753892

Claim:
A method for detecting and classifying prostate cancer in a human subject, comprsing: selecting Phosphodiesterase 4D7 (PDE4D7) as a marker for detecting form of prostate cancer, determining the expression level of the PDE4D7 marker in a primary tumor sample taken from the subject, the determining performed by measuring nucleic acid levels, protein levels, or the biological activity of PDE4D7, comparing the determined expression level of PDE4D7 to at least one reference gene selected from the group consisting of GAPDH and PBGD, classifying the subject as having either (a) hormone-dependent or hormone-sensitive prostate cancer or (b) hormone-resistant prostate cancer, wherein hormone-resistant prostate cancer is identified by an expression level of PDE4D7 that is at least 0.1 fold reduced in t he primary tumor sample relative to the at least one reference gene.