Patent ID: 7598272

Claim:
A compound of the formula: or pharmaceutically acceptable salts, crystal forms or diastereomers thereof, wherein: D is: where X 1 , X 2 , X 3 , X 4 are optionally substituted carbon, or one of X 1 , X 2 , X 3 , X 4 is N; R 2 is 0-4 substituents independently chosen from H, halogen, C 1-4 alkyl, CH 2 F, CHF 2 , CF 3 , OCF 3 , aryl, hetaryl, C 1-4 alkylOC 1-4 alkyl, C 1-4 alkylOaryl, C 1-4 alkylNR 3 R 4 , CO 2 R 3 , CONR 3 R 4 , CONR 3 SO 2 R 4 , NR 3 R 4 , C 1-4 alkylNR 3 R 4 , nitro, NR 3 COR 4 , NR 5 CONR 3 R 4 , NR 3 SO 2 R 4 , C 1-4 alkylNR 3 COR 4 , C 1-4 alkylNR 5 CONR 3 R 4 , or C 1-4 alkylNR 3 SO 2 R 4 ; R 3 and R 4 are each independently H, halogen, CH 2 F, CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkyl cycloalkyl, C 1-4 cyclohetalkyl, aryl, C 1-4 alkyl aryl, hetaryl, C 1-4 alkyl hetaryl, or may be joined to form an optionally substituted 3-8 membered (saturated or unsaturated) ring optionally containing an atom selected from O, S, NR 6 ; R 5 is H, C 1-4 alkyl, halogen, CH 2 F, CHF 2 , CF 3 , aryl or hetaryl; R 6 is H, C 1-4 alkyl, aryl, hetaryl, C 1-4 alkyl aryl, or C 1-4 alkyl hetaryl; R 1 is H, C 1-4 alkyl, C 1-6 cycloalkyl; Q is a bond, CH 2 , C 1-4 alkyl; A is aryl, hetaryl optionally substituted with 0-3 substituents independently chosen from halogen, C 1-4 alkyl, CH 2 F, CHF 2 , CF 3 , OCF 3 , CN, NR 8 R 9 , aryl, hetaryl, C 1-4 aryl, C 1-4 hetaryl, C 1-4 alkylNR 8 R 9 , OC 1-4 alkylNR 8 R 9 , nitro, NR 10 C 1-4 NR 8 R 9 , NR 8 COR 9 , NR 10 CONR 8 R 9 , NR 8 SO 2 R 9 , CONR 8 R 9 , or CO 2 R 8 , where R 8 and R 9 are each independently H, C 1-4 alkyl, aryl or which together form an optionally substituted 4-8 membered ring which may contain a heteroatom selected from O, S, NR 11 , where R 11 is C 1-4 alkyl, and R 10 is selected from H, C 1-4 alkyl; and W is H, C 1-4 alkyl, or C 2-6 alkenyl, where C 1-4 alkyl or C 2-6 alkenyl may be optionally substituted with C 1-4 alkyl, OH, OC 1-4 alkyl, NR 12 R 13 ; and R 12 , and R 13 are each independently H, C 1-4 alkyl, or may be joined to form an optionally substituted 3-8 membered ring optionally containing an atom selected from O, S, and NR 14 where R 14 is H or C 1-4 alkyl.