Patent ID: 7151196

Claim:
A compound of the formula: wherein X is O, N—OR a , N—N(R a ) 2 , or C 1-6 alkylidene, wherein said alkylidene group is optionally substituted with hydroxyl, amino, O(C 1-4 alkyl), NH(C 1-4 alkyl) or N(C 1-4 alkyl) 2 ; R 1 is fluoro, chloro, bromo, iodo, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, aryl, or heteroaryl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl groups are optionally substituted with one, two or three groups selected from the group consisting of fluoro, chloro, bromo, iodo, cyano and OR a ; R 2 is hydrogen, R a , (C═O)R a or (C═O)OR a ; R 3 is hydrogen, fluoro, chloro, bromo, iodo, C 1-2 alkyl, cyano or OR a ; R 4 is hydrogen, fluoro, chloro, bromo or hydroxyl; R 5 is hydrogen, fluoro, chloro, bromo or hydroxyl; Or R 4 and R 5 , when taken together with the carbon atom to which they are attached, form a carbonyl group; R 6 is hydrogen, fluoro, chloro or C 1-5 alkyl, wherein said alkyl group is optionally substituted with a group selected from the group consisting of chloro, bromo, iodo, OR a and 1–5 fluoro; R a is hydrogen, C 1-4 alkyl or phenyl, wherein said alkyl and phenyl groups are optionally substituted with a group selected from the group consisting of hydroxyl, amino, O(C 1-4 alkyl), NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , chloro, bromo, 1–5 fluoro, iodo, cyano and OR a ; when two or more R a groups are present, they are independently selected; with the proviso that when R 2 and R 6 are hydrogen, R 1 is not methyl; and when R 6 is propyl, R 1 is not methyl, ethyl, bromo or trifluoromethyl; or a pharmaceutically acceptable salt or stereoisomer thereof.