Patent ID: 8052998

Claim:
An oral particulate vector with improved absorption of one or more active principles following oral administration of the particulate vector to a subject in need thereof, wherein the particulate vector comprises at least one active principle and a polymeric matrix comprising a mixture of at least one biodegradable polymer and at least one non-water soluble polycationic polymer, wherein: the biodegradable polymer is selected from the group consisting of polyesters, lactic acid polymers, copolymers of lactic acid and of glycolic acid (PLGA), poly-ε-caprolactone (PCL), polyanhydrides, poly(amides), poly(urethanes), poly(carbonates), poly(acetals), and poly(ortho-esters); the non-water soluble polycationic polymer is selected from the group consisting of polycationic chitosan, polycationic polylysine and the polycationic copolymers of acrylic and methacrylic acid esters with trimethylammonioethyl methacrylate chloride; the biodegradable polymer and the polycationic polymer are present in equivalent amounts; the active principle is selected from the group consisting of insulin, heparin, low molecular weight heparin and heparin with a molecular weight between 2,500 D and 40,000 D; and the biodegradable polymer and the polycationic polymer are non-enteric.