Patent ID: 8871903

Claim:
A method for preparing one or more peptide-[(Ar 1 —Ar 2 —Ar 1 )]-peptide structures, the method comprising: a) providing one or more peptides immobilized on a solid support, wherein the one or more peptides have a deprotected or free amine group; b) contacting the one or more immobilized peptides with a portion of a π-conjugated subunit comprising a first arene (Ar 1 ) and differentially substituted with a halide and a carboxylic acid group to promote N-acylation of the amine termini of the one or more peptides; c) contacting the one or more immobilized peptides of step (b) with a second arene (Ar 2 ) disubstituted with mutually reactive functionality for transmetallation in the presence of a palladium catalyst to promote site-site cross coupling dimerization between the disubstituted second arene and the two N-acylated amine termini of the one or more peptides formed in step (b); and d) cleaving the product formed in step (c) to form one or more peptide-[(Ar 1 —Ar 2 —Ar 1 )]-peptide structures.