Patent ID: 8158584

Claim:
A pharmaceutical preparation comprising an ALK1-Fc fusion protein comprising: a polypeptide having an amino acid sequence that is at least 97% identical to the sequence of amino acids 22-118 of SEQ ID NO:1, which polypeptide is fused to an Fc portion of an immunoglobulin, wherein the ALK1-Fc fusion protein binds to GDF5, GDF7 and BMP9 with a K D of less than 1×10 −7 M and binds to TGFβ-1 with a K D of greater than 1×10 −6 , wherein at least 90% of the ALK1-Fc fusion protein is present in a dimeric form, and wherein the ALK1-Fc fusion protein comprises the amino acid sequence of SEQ ID NO: 3.