Patent ID: 7588756

Claim:
A method for treating cardiac insufficiency in a subject, comprising administering to the subject a compatible auxiliary or support and a nucleic acid encoding a polypeptide selected from the group consisting of at least one S100A1 protein, wherein S100A1 contains the amino acid sequence shown in SEQ ID NO:2 or has at least 95% homology thereto, and a plurality of hydrophobic fragments of said S100A1 selected from the group consisting of the amino acid sequences shown in SEQ ID NO:34 and SEQ ID NO:36 or having at least 90% homology thereto, wherein said polypeptide increases the systolic Ca 2+ release from the sarcoplasmic reticulum and increases the rate of Ca 2+ uptake into the sarcoplasmic reticulum, wherein said nucleic acid is administered intracoronally.