Patent ID: 8435944

Claim:
A method of increasing the testosterone blood level of an adult male subject in need thereof comprising applying to at least one axilla of the subject, without occlusion by a patch device, a non-occlusive transdermal drug delivery composition consisting of: (a) a pharmaceutically effective amount of testosterone; (b) one or more lower alkyl alcohols, wherein the combined volume of the lower alkyl alcohols is more than 60% (v/v) of the composition; (c) one or more penetration enhancers selected from the group consisting of glycols, oleic acid, isopropyl myristate, cyclopentadecanone, sorbitan monooleate, octisalate, octyldimethyl-para-aminobenzoate, octyl para-methoxycinnamate, and combinations thereof; (d) one or more viscosity modulating agents; (e) optionally, an activator for the viscosity modulating agent; (f) optionally, an antiperspirant and/or deodorant agent; and (g) optionally, water wherein the composition is applied in an amount effective to achieve a testosterone blood level in the subject of at least 200 ng/dL.