Patent ID: 7312230

Claim:
A compound of the Formula I: wherein: R 1 is indolyl or quinolinyl, each optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, arylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfonylamino, arylsulfonylamino and trifluoromethyl; R 2 is phenyl optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, arylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfonylamino, arylsulfonylamino and trifluoromethyl; R 3 from phenyl optionally substituted with one or more substituents selected independently from hydroxy, cyano, lower alkyl, lower alkoxy, alkythio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylcarbonylamino, arylcarbonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylsulfonylamino, arylsulfonylamino and trifluoromethyl; R 4 is -COOH; A is —O(CH 2 ) p —, —(CH 2 ) p O—, or —(CH 2 ) p; B is —(CH 2 ) q ; m, p, and q are each 1; and n and r are each 0; or a pharmaceutically acceptable salt thereof.