Patent ID: 7087614

Claim:
A compound of formula III or a stereoisomer, or a pharmaceutically acceptable salt, or a hydrate, thereof, wherein: R 1a is hydrogen or alkyl; R 2a is W is S; X 1 is alkoxy; and X 2 is alkyl; Z* is halogen, haloalkyl, oxazolyl, —NR 3a R 4a , —C(O)—N(H)-alkylene-COOH, or phenyl which is unsubstituted or substituted with heteroaryl, CO t H, or CO t T 6 ; R 3a is hydrogen or alkyl; R 4a is alkyl, alkoxy, unsubstituted or substituted (heteroaryl)alkyl, unsubstituted or substituted heterocyclo, unsubstituted or substituted (heterocyclo)alkyl, or (aryl)alkyl wherein the aryl group is substituted with one or two groups T 1* and/or T 2* and/or further substituted with a group T 3* ; or R 3a and R 4a together with the nitrogen atom to which they are attached combine to form an unsubstituted or substituted heterocyclo ring; R 5a is an unsubstituted or substituted (heteroaryl)alkyl, or (aryl)alkyl wherein the aryl group is substituted with one or two groups T 1* and/or T 2* and/or further substituted with a group T 3* ; or R 5a and R 6a together with the nitrogen atom to which they are attached combine to form an unsubstituted or substituted heterocyclo ring; R 6a is hydrogen or alkyl; J* is hydrogen or alkyl; T 1* and T 2* are independently alkoxy, alkoxycarbonyl, heteroaryl, SO 3 H, or SO 2 R 8a where R 8a is alkyl, amino, alkylamino or dialkylamino; or T 1* and T 2* together with the aryl ring to which they are attached combine to form a bicyclic ring; T 3* is H, alkyl, halo, haloalkyl, or cyano; t is 1 or 2; and T 6 is alkyl, haloalkyl, cycloalkyl, alkoxy, or heteroaryl.