Patent ID: 7091187

Claim:
A compound of the formula: wherein M represents a group of Formula II: wherein (i) Z and W independently are >C═O, >CH 2 , >CH—NR t R s , >N—R N or >C═N—R M , wherein R t and R s independently are hydrogen or alkyl; R M is hydroxy, alkoxy, substituted alkoxy or OR p ; R N is hydrogen, R p , alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, or —C(X)—NR t R s ; wherein X is ═O or ═S; provided that Z and W cannot both simultaneously be, >C═O, >CH 2 , >CH—NR t R s , >N—R N , >C═N—R M or a bond; (ii) U and Y independently are hydrogen, halogen, alkyl, or hydroxyalkyl; (iii) R 1 is hydroxy, OR p , —O—S 2 group or an ═O; (iv) S 1 is a sugar moiety of Formula III: wherein R 8 and R 9 are both hydrogen or together form a bond, or R 9 is hydrogen and R 8 is —N(CH 3 )R y , wherein R y is R p , R z or —C(O)R z , wherein R z is hydrogen or alkyl or alkenyl or alkynyl or cycloalkyl or 1 or heteroaryl or alkyl substituted with C 2 -C 7 -alkyl, C 2 -C 7 -alkenyl, C 2 -C7-alkynyl, aryl or heteroaryl; R 10 is hydrogen or R p ; S 2 sugar moiety of Formula IV: wherein R 3 ′ is hydrogen or methyl; R 11 is hydrogen, R p , or O—R 11 is a group that with R 12 and with C/4″ carbon atom forms a >C═O or epoxy group; R 12 is hydrogen or a group that with O—R 11 group and with C/4″ carbon atom forms a >C═O or epoxy group; (vi) R 2 is hydrogen hydroxy, OR p or alkoxy; (vii) A is hydrogen or methyl; (viii) B is methyl or epoxy; (ix) E hydrogen or halogen; R 3 is hydroxy, OR p , alkoxy or R 3 is a group that with R 5 and with C/11 and C/12 carbon atoms forms a cyclic carbonate or carbamate, or if W or Z is >N—R N R 3 is a group at with W or Z forms a cyclic carbamate; (xi) R 4 is C 1 -C 4 alkyl; (xii) R 5 is hydrogen hydroxy, OR p , C 1 -C 4 alkoxy, or a group that with R 3 and with C/11 an C/12 carbon atoms forms a cyclic carbonate or carbamate; (xiii) R 6 is hydrogen or C 1 -C 4 -alkyl; and R p iss hydroxyl or amino protective group; wherein M has a linkage site through which it is linked to S via linking group L; provided that linkage site at one or more of the following: a) any reactive hydroxy, nitrogen, or epoxy group located on S 1 . S 2 , or an aglycone oxygen if S 1 and/or S 2 is cleaved off; b) a reactive >N—R N or —NR t R s or oxo group located on Z or W; c) a reactive hydroxy group located at any one of R 1 , R 2 , R 3 , and R 5 ; d) any other group that can be first derivatized to a hydroxy or —NR t R s group and S represents a group of Formula X: wherein R a and R b independently represents, hydrogen or halogen; R c is hydroxy, alkoxy, alkyl, thiocarbamoyl, carbamoyl or a valence-bond; R d and R e independently represents: hydrogen, hydroxy, methyl or C 1 -C 4 -alkoxy or each are a group that forms a 1,3-dioxolane ring with the other or a valence bond; R f is hydrogen, hydroxy, chloro, or forming a keto group with the carbon atom it is attached to; R j is hydrogen or halogen; or a pharmaceutically acceptable salt or solvate thereof; wherein L is a linker molecule to which each of M and S are covalently linked.