Patent ID: 8288431

Claim:
A compound of the formula wherein X is selected from the group consisting of F, Cl and Br; Y is a mono substituting group selected from H or F; R 1 is selected from the group consisting of lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R 2 is selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl; W is NH, O or none; R 3 is selected from the group consisting of (CH 2 ) n â€”Râ€², (CH 2 ) n â€”NRâ€²Râ€³, (CH 2 ) n â€”NRâ€²CORâ€³, (CH 2 ) n â€”NRâ€²SO 2 Râ€³, (CH 2 ) n â€”COOH, (CH 2 ) n â€”COORâ€², (CH 2 ) n â€”CONRâ€²Râ€³, (CH 2 ) n â€”ORâ€², (CH 2 ) n â€”SRâ€², (CH 2 ) n â€”SORâ€², (CH 2 ) n â€”SO 2 Râ€², (CH 2 ) n â€”CORâ€², (CH 2 ) n â€”SO 3 H, (CH 2 ) n â€”SONRâ€²Râ€³ and (CH ;2 ) n â€”SO 2 NRâ€²Râ€³; n is 0, 1, 2 or 3; Râ€² and Râ€³ are independently selected from H, lower alkyl, substituted lower alkyl, lower cycloalkyl, substituted lower cycloalkyl, lower alkenyl, substituted lower alkenyl, lower cycloalkenyl, substituted lower cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle or substituted heterocycle and in the case of Râ€² and Râ€³ may independently link to form a cyclic structure selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle; and enantiomers and the pharmaceutically acceptable salts thereof.