Patent ID: 8242279

Claim:
A method for preparing a compound of Formula 1 wherein R 1 is NHR 3 ; R 2 is CH 3 or Cl; and R 3 is H, C 1 -C 4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; comprising contacting (1) a compound of Formula 2 wherein X is Br or Cl; with (2) a metal cyanide reagent comprising one or more compounds selected from the group consisting of alkali metal cyanides and copper(I) cyanide, (3) a copper(I) salt reagent, (4) an iodide salt reagent and (5) at least one compound of Formula 3 wherein R 5 is H, phenyl or benzyl; or C 1 -C 12 alkyl optionally substituted with NR 9 R 10 ; each R 6 , R 7 and R 8 is independently H, C 1 -C 12 alkyl, phenyl or benzyl; or R 6 and R 7 are taken together as —CH═CH—CH═CH—; and R 9 and R 10 are taken together as —CH═N—CH═CH— optionally substituted with up to 3 substituents independently selected from C 1 -C 12 alkyl; provided that when X is Cl, then R 2 is methyl.