Patent ID: 7820720

Claim:
A pharmaceutical formulation suitable for topical delivery of terbinafine, comprising, in an aqueous solution, i) terbinafine or a pharmaceutically acceptable salt thereof in an amount ranging from about 0.5% to about 10% by weight, ii) a phospholipid in an amount ranging from about 4% to about 7% by weight, and iii) a non-ionic surfactant in an amount ranging from about 1% to about 4%, wherein the molar ratio of the phospholipid to the non-ionic surfactant is from about 1:1 to about 5:1, and wherein the phospholipid is a compound of Formula III: R 1 —CH 2 —CHR 2 —CR 3 H—O—PHO 2 —O—R 4 (III) or an anion thereof, wherein R 1 and R 2 are independently hydrogen, OH, acyl, alkyl, n-hydroxyacyl or n-hydroxyalkyl, or are derived from a fatty acid or a fatty alcohol, wherein R 1 and R 2 may also be branched, with one or more methyl groups, may be saturated or mono-, di-, or poly-unsaturated, and wherein R 1 and R 2 are not both hydrogen, OH, or C 1 -C 3 alkyl; R 3 is hydrogen; and R 4 is hydrogen, a short-chain alkyl group substituted by a tri-short-chain alkylammonium group, an amino-substituted short-chain alkyl group, serine, glycerol, or inositol.