Patent ID: 7074389

Claim:
A pharmaceutical composition comprising a therapeutically effective amount of vitamin A, a vitamin A derivative, or a combination thereof within a unilamellar liposome targeted to receptors of alveolar macrophages, wherein: (a) the lipid composition of said unilamellar liposome consists of phosphatidylcholine and at least one other phospholipid selected from the group consisting of phosphatidylinositol, phosphatidylserine, and cardiolipin in their lipid bilayer; (b) the ratio of said phosphatidylcholine to said at least one other phospholipid is 75:25 to 65:35; (c) said unilamellar liposome has a diameter of about 0.1 Î¼m to about 0.4 Î¼m; and d) the vitamin A derivative is selected from the group consisting of retinol, retinal, retinoic acid, Î²-carotene, and esters thereof, and further wherein the pharmaceutical composition is in an inhalable form for treatment of tracheo-bronchial diseases in a subject.