Patent ID: 6984637

Claim:
A compound selected from compounds of Formula (I): wherein: R 1 and R 2 are, independently of each other, hydrogen or alkyl; n is an integer from 0 to 2; m is an integer from 0 to 3; Ar and Ar 1 are, independently of each other, aryl or heteroaryl, wherein at least one of Ar and Ar 1 is heteroaryl; F is alkylene, alkenylene or a bond; each R is independently hydrogen or alkyl, or R together with either R 3 or R 4 and the atoms to which they are attached form a carbocycle or a heterocycle; R 3 and R 4 are, independently of each other, selected from: (i) hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, heteroalkyl, cyano or -(alkylene)-C(O)—Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy or heteroaralkyloxy, provided that both R 3 and R 4 are not hydrogen; or (ii) R 3 and R 4 together with the carbon atom to which they are attached form a carbocycle or a heterocycle; E is —SO 2 N(R 5 )—, —N(R 6 )SO 2 N(R 5 )—, or —N(R 6 )SO 2 — wherein: R 5 is hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, heteroalkyl, or -(alkylene)-C(O)—Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy or heteroaralkyloxy; R 6 is hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocyclylalkyl, heteroalkyl, or -(alkylene)-C(O)—Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy or heteroaralkyloxy, provided that when E is —SO 2 N(R 5 )— or —N(R 6 )SO 2 N(R 5 )—, then m>0; Q is —R 7 —W—R 8 — wherein: R 7 is an alkylene chain of between 1-6 carbon atoms inclusive; R 8 is a bond or an alkylene chain of between 1-4 carbon atoms inclusive; W is a bond or a group selected from —C(O)—, —NR 9 —, —O—, —S(O) 0-2 —, —N(R 9 )C(O)—, —N(R 9 )SO 2 —, —SO 2 N(R 9 )—, —N(R 9 )C(O)N(R 9 )—, —N(R 9 )SO 2 N(R 9 )— or —N(R 9 )C(S)N(R 9 )— wherein: R 9 is hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)—Z where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy or heteroaralkyloxy; and individual isomers, mixtures of isomers and pharmaceutically acceptable salts thereof.