Patent ID: 6986987

Claim:
A method of correlating an FcαRI induced function of intracellular calcium flux or interleukin-6 release or TNFα release of a cell in a host expressing FcαRI with an FcαRI amino acid sequence, said method comprising: identifying said FcαRI genotype of said cell at nucleotide 844 corresponding to an amino acid sequence codon 248 as being glycine; quantifying said FcαRI induced function by said cell expressing FcαRI; and comparing FcαRI induced function by said cell and FcαRI induced function by a second cell, said second cell expressing a second FcαRI genotype at nucleotide 844 that corresponds to serine at said amino acid sequence codon 248, wherein the FcαRI induced function of intracellular calcium flux or interleukin-6 release or TNFα release of the cell in the host expressing FcαRI correlates with the FcαRI amino acid sequence codon 248.