Patent ID: 7157424

Claim:
A pharmaceutical composition comprising: (a) a compound of formula (I): wherein: ----- designates an optional bond forming a double bond between positions 13 and 14; R 1 is H, halo, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 3-6 cycloalkoxy, hydroxy, or N(R 5 ) 2 , wherein each R 5 is independently H, C 1-6 alkyl or C 3-6 cycloalkyl; L 1 , L 2 are each H; R 2 is H, halo, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 haloalkyl, C 1-6 thioalkyl, C 1-6 alkoxy, C 3-6 cycloalkoxy, C 2-7 alkoxyalkyl, C 6 or 10 aryl or Het, wherein Het is a five-, six-, or seven-membered saturated or unsaturated heterocycle containing from one to four ring heteroatoms selected from nitrogen, oxygen and sulfur; said cycloalkyl, aryl or Het being optionally substituted with R 6 , wherein R 6 is H, halo, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 3-6 cycloalkoxy, NO 2 , N(R 7 ) 2 , NH—C(O)—R 7 ; or NH—C(O)—NH—R 7 , wherein each R 7 is independently: H, C 1-6 alkyl or C 3-6 cycloalkyl; or R 6 is NH—C(O)—OR 8 wherein R 8 is C 1-6 alkyl or C 3-6 cycloalkyl; R 3 is R 9 O— or R 9 NH—, wherein R 9 is C 1-6 alkyl or C 3-6 cycloalkyl; R 4 is H or from one to three substituents on any available carbon atom at positions 8, 9, 10, 11, 12, 13 or 14, said substituent independently selected from the group consisting of: C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, hydroxy, halo, amino, oxo, thio or C 1-6 thioalkyl; and or a tautomer thereof; (b) about 0.1% to 10% by weight of a pharmaceutically acceptable amine or a mixture of pharmaceutically acceptable amines; (c) about 0.1% to 10% by weight of a pharmaceutically acceptable base or a mixture of pharmaceutically acceptable bases; (d) one or more pharmaceutically acceptable oils; (e) optionally one or more pharmaceutically acceptable hydrophilic solvents; (f) optionally one or more pharmaceutically acceptable polymers; and (g) optionally one or more pharmaceutically acceptable surfactants; and wherein the amine component (b) and the base component (c) are not the same compound.