Patent ID: 6855829

Claim:
An opener or activator compound which modulates the biological activity of central nervous system-associated KCNQ potassium channel polypeptides by hyperpolarizing neurons that fire before or during a migraine headache or migraine-related disorder, the opener or activator compound comprising a compound according to Formula I and pharmaceutically acceptable salts thereof, Formula I having the structure wherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen, C 1-4 alkyl halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluromethylphenyl; R 5 is C 16 alkyl, optionally substituted with one to three same or different groups selected from fluoro and chloro, provided that R 5 is not C 1-6 alkyl when Y is O; Y is O or S; and R 6 and R 7 are each independently hydrogen, chloro, bromo or trifluoromethyl.