Patent ID: 8546432

Claim:
A compound of formula (I): or a pharmaceutically acceptable form thereof; wherein: R A is selected from C 6-14 aryl and 5-14 membered heteroaryl; R B is selected from C 6-14 aryl and 5-14 membered heteroaryl, wherein R B is substituted at least with the group -L-R D ; R C is selected from C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl, with the proviso that R C is not —CH 3 ; wherein: L is a covalent bond or a divalent C 1-10 hydrocarbon chain, wherein one, two or three methylene units of L are optionally and independently replaced with one or more —O—, —S—, —NR B8 —, —(C═NR B8 )—, —C(═O)—, —C(═S)—, —S(═O)—, —S(═O) 2 —, divalent carbocyclyl, divalent heterocyclyl, divalent aryl or divalent heteroaryl group; R D is selected from N 3 , —SO 2 H, —SO 3 H, —C(═O)R B7 , —CO 2 H, —CHO, —C(OR B9 ) 2 , —CO 2 R B7 , —OC(═O)R B7 , —OCO 2 R B7 , —C(═O)N(R B8 ) 2 , —OC(═O)N(R B8 ) 2 , —NR B8 C(═O)R B7 , —NR B8 CO 2 R B7 , —NR B8 C(═O)N(R B8 ) 2 , —C(═NR B8 )OR B7 , —OC(═NR B8 )R B7 , —OC(═NR B8 )OR B7 , —C(═NR B8 )N(R B8 ) 2 , —OC(═NR B8 )N(R B8 ) 2 , —NR B8 C(NR B8 )N(R B8 ) 2 , —C(═O)NR B8 SO 2 R B7 , —NR B8 SO 2 R B7 , —SO 2 N(R B8 ) 2 , —SO 2 R B7 , —SO 2 OR B7 , —OSO 2 R B7 , —S(═O)R B7 , —OS(═O)R B7 —C(═S)N(R B8 ) 2 , —C(═O)SR B7 , —C(═S)SR B7 , —SC(═S)SR B7 , —P(═O) 2 R B7 , —OP(═O) 2 R B7 , —P(═O)(R B7 ) 2 , —OP(═O)(R B7 ) 2 , —OP(═O)(OR B9 ) 2 , —P(═O) 2 N(R B8 ) 2 , —OP(═O) 2 N(R B8 ) 2 , —P(═O)(NR B8 ) 2 , —OP(═O)(NR B8 ) 2 , —NR B8 P(O)(OR B9 ) 2 , NR B8 P(═O)(NR B8 ) 2 , —B(OR B9 ) 2 , —BR B7 (OR B9 ), and tetrazolyl; each instance of R B7 is, independently, selected from C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl; each instance of R B8 is, independently, selected from hydrogen, —OH, —OR B7 , —N(R B9 ) 2 , —CN, —C(═O)R B7 , —C(═O)N(R B9 ) 2 , —CO 2 R B7 , —SO 2 R B7 , —C(═NR B9 )OR B7 , —C(═NR B9 )N(R B9 ) 2 , —SO 2 N(R B9 ) 2 , —SO 2 R B9 , —SO 2 OR B9 , —SOR B7 , —C(═S)N(R B9 ) 2 , —C(═O)SR B9 , —C(═S)SR B9 , —P(═O) 2 R B7 , —P(═O)(R B7 ) 2 , —P(═O) 2 N(R B9 ) 2 , —P(═O)(NR B9 ) 2 , C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl, or two R B8 groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring; and each instance of R B9 is, independently, selected from hydrogen, C 1-10 alkyl, C 1-10 perhaloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, 3-14 membered heteroaliphatic, C 3-10 carbocyclyl, 3-14 membered heterocyclyl, C 6-14 aryl, and 5-14 membered heteroaryl, or two R B9 groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring.