Patent ID: 8874204

Claim:
An implantable medical device comprising: an implantable pulse generator including a surface, the implantable pulse generator adapted to deliver a pacing therapy and control the delivery of the pacing therapy by executing a cardiac remodeling control algorithm, wherein the surface comprises a preformed delaminated sheet of isolated decellularized extracellular matrix (ECM) populated with isolated donor cells, or a preformed delaminated sheet of isolated decellularized ECM infused with one or more isolated cytokines, wherein the ECM in the preformed delaminated sheet of ECM is xenogeneic or allogeneic and has a three dimensional microstructure of native ECM, wherein the preformed delaminated ECM sheet comprises a plurality of different molecules including collagens present in native ECM, wherein the isolated donor cells are attached to and within the three dimensional microstructure of the preformed delaminated ECM sheet, wherein the preformed ECM sheet is formed as a sheet before the preformed ECM sheet is applied to the surface, and wherein the isolated donor cells are allogeneic or autologous.