Patent ID: 8765918

Claim:
A pharmaceutical composition comprising a human antibody, or antigen binding portion thereof, that binds to and neutralizes the p40 subunit of human interleukin (IL-12) and dissociates from the human IL-12 with a k off rate constant of about 1×10 −4 s −1 to 1×10 −5 s −1 , as determined by surface plasmon resonance; and at least one additional agent selected from the group consisting of a buffer, a polyalcohol and a surfactant; wherein the antibody, or antigen binding portion thereof, is capable of binding to a first heterodimer and is also capable of binding to a second heterodimer, wherein the first heterodimer comprises the p40 subunit of human IL-12 and the p35 subunit of human IL-12, and wherein the second heterodimer comprises the p40 subunit of human IL-12 and a p19 subunit.