Patent ID: 7879334

Claim:
An isolated fusion molecule comprising a first polypeptide sequence consisting of the amino acid sequence of SEQ ID NO: 3 and being capable of specific binding to a native IgG inhibitory receptor comprising an immune receptor tyrosine-based inhibitory motif (ITIM), expressed on mast cells, basophils or B cells, said first polypeptide sequence being functionally connected with a polypeptide linker of between about 5 to 25 amino acids to a second polypeptide sequence consisting of a native allergen polypeptide sequence selected from SEQ ID NOs: 8 through 173, said second polypeptide sequence being capable of specific binding indirectly to a native IgE receptor (FcεR), wherein said polypeptide linker allows said first polypeptide and said second polypeptide to independently assume a tertiary conformation effective to allow binding with a native receptor, and wherein said isolated fusion molecule is capable of cross-linking said native IgG inhibitory receptor and said native IgE receptor.