Patent ID: 8600513

Claim:
A prediction and closed-loop stimulation method for neurological dysfunction therapy, comprising: (a) detecting neuronal electrical activity of a brain region via an array of electrodes, wherein said array of electrodes is adapted to cover a region of dysfunctional neuronal activity of said brain region; (b) continuously detecting in each of said electrodes periods that last at least 30 seconds with (i) persistent chaotic dynamics in local field potentials, (ii) persistent values of high frequency oscillations in the range of 200-300 Hz within said local field potentials, and (iii) persistent low firing rates close to zero; (c) predicting for each of said electrodes in said array of electrodes a future occurrence of a neurological dysfunction, wherein said future occurrence of said neurological dysfunction is predicted when a prediction module computes that (j) said persistent chaotic dynamics exceeds a predefined threshold for said persistent chaotic dynamics for said at least 30 seconds, (jj) said persistent values of high frequency oscillations exceeds a predefined threshold for said persistent high frequency oscillations for said at least 30 seconds, (jjj) said persistent low firing rates exceed a predefined threshold defined for said persistent low firing rates for said at least 30 seconds, or (ij) any combination thereof; and (d) selecting using a neuromodulation module a subset of electrodes from said array of electrodes, wherein said subset of electrodes is defined as said electrodes in said array of electrodes where said future occurrence of said neurological dysfunction was predicted by said prediction module and then prior to an onset of said neurological dysfunction stimulating said brain region through said subset of electrodes selected by said neuromodulation module using an intermittent therapeutic stimulation pattern with a frequency between 150 and 200 Hz.