Patent ID: 8343502

Claim:
A method to reduce tumor burden, increase survival, or inhibit tumor growth in an animal that has cancer, comprising administering a composition to an animal that has a cancer, to reduce tumor burden, increase survival, or inhibit tumor growth in the animal, the composition comprising: a) a yeast vehicle; and b) a fusion protein expressed by the yeast vehicle, the fusion protein comprising: i) an amino acid sequence comprising positions 57-65 of a Ras protein, wherein, as compared to wild-type Ras protein, the glutamine at position 61 is mutated; and ii) an amino acid sequence comprising positions 3-165 of a Ras protein, wherein, as compared to wild-type Ras protein, the glycine at position 12 is mutated, and the glutamine at position 61 is mutated; wherein the amino acid sequence of (i) is appended to the N-terminus of the amino acid sequence of (ii).