Patent ID: 8859597

Claim:
A sterile pharmaceutical composition comprising a compound of the following formula and a pharmaceutically acceptable carrier suitable for local administration into the ear: wherein: R 43 is C 6 -C 10 aryl or heteroaryl including 5-10 atoms, each of which is optionally substituted with from 1-5 R m ; R 44 is: (i) C 6 -C 10 aryl or heteroaryl including 5-10 atoms, each of which is optionally substituted with from 1-5 R m ; or (ii) —Z 4 —(C 1 -C 6 alkyl), wherein: Z 4 is a bond or NH; and the C 1 -C 6 alkyl is substituted with one of the following: (a) heterocyclyl including 5-6 atoms, which is optionally substituted with from 1-3 substituents independently selected from oxo and C 1 -C 6 alkyl; or (b) phenoxy, which is optionally substituted with from 1-5 R m ; and R m at each occurrence is, independently: (i) halo; NH 2 ; NH(C 1 -C 3 alkyl); N(C 1 -C 3 alkyl) 2 ; hydroxy; C 1 -C 6 alkoxy or C 1 -C 6 haloalkoxy; nitro; or cyano; or (ii) C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; or a pharmaceutically acceptable salt thereof.