Patent ID: 8133511

Claim:
A matrix controlled diffusion drug delivery system comprising a therapeutically effective amount of one or more pharmaceutically active agents covalently bound to a polymerization product of a monomeric mixture comprising one or more silicon-containing monomers of Formula I: wherein L can be the same or different and is selected from the group consisting of urethanes, carbonates, carbamates, carboxyl ureidos, sulfonyls, a straight or branched, substituted or unsubstituted C 1 -C 30 alkyl group, a C 1 -C 30 fluoroalkyl group, a substituted or unsubstituted C 1 -C 20 ester group, an alkyl ether, cycloalkyl ether, cycloalkenyl ether, aryl ether, arylalkyl ether, a polyether containing group, an ureido group, an amide group, an amine group, a substituted or unsubstituted C 1 -C 30 alkoxy group, a substituted or unsubstituted C 3 -C 30 cycloalkyl group, a substituted or unsubstituted C 3 -C 30 cycloalkylalkyl group, a substituted or unsubstituted C 3 -C 30 cycloalkenyl group, a substituted or unsubstituted C 5 -C 30 aryl group, a substituted or unsubstituted C 5 -C 30 arylalkyl group, a substituted or unsubstituted C 5 -C 30 heteroaryl group, a substituted or unsubstituted C 3 -C 30 heterocyclic ring, a substituted or unsubstituted C 4 -C 30 heterocyclolalkyl group, a substituted or unsubstituted C 6 -C 30 heteroarylalkyl group, a C 5 -C 30 fluoroaryl group, or a hydroxyl substituted alkyl ether and combinations thereof; X − is at least a single charged counter ion; n is an integer from 1 to about 300; R1, R2, R3, R4, R5, R6, R7 and R8 are independently hydrogen, a straight or branched, substituted or unsubstituted C 1 -C 30 alkyl group, a C 1 -C 30 fluoroalkyl group, a C 1 -C 20 ester group, an alkyl ether, cycloalkyl ether, cycloalkenyl ether, aryl ether, arylalkyl ether, a polyether containing group, an ureido group, an amide group, an amine group, a substituted or unsubstituted C 1 -C 30 alkoxy group, a substituted or unsubstituted C 3 -C 30 cycloalkyl group, a substituted or unsubstituted C 3 -C 30 cycloalkylalkyl group, a substituted or unsubstituted C 3 -C 30 cycloalkenyl group, a substituted or unsubstituted C 5 -C 30 aryl group, a substituted or unsubstituted C 5 -C 30 arylalkyl group, a substituted or unsubstituted C 5 -C 30 heteroaryl group, a substituted or unsubstituted C 3 -C 30 heterocyclic ring, a substituted or unsubstituted C 4 -C 30 heterocyclolalkyl group, a substituted or unsubstituted C 6 -C 30 heteroarylalkyl group, fluorine, a C 5 -C 30 fluoroaryl group, or a hydroxyl group, and V is independently a polymerizable ethylenically unsaturated organic radical; wherein the matrix controlled diffusion drug delivery system is sized and configured for back of the eye delivery.