Patent ID: 8105630

Claim:
A composition, comprising: an extremely poorly water-soluble drug; and a porous silica material; wherein: the composition is obtained by treating a mixture comprising the porous silica material and the extremely poorly water-soluble drug with a supercritical fluid or subcritical fluid of carbon dioxide; the extremely poorly water-soluble drug has a solubility in water at 25° C. of less than 10 μg/mL prior to treatment; the porous silica material has an average pore diameter of from 1 to 20 nm, a total pore volume of pores having diameters within ±40% of the average pore diameter accounts for at least 60% of a volume of all pores of the porous silica material, and the porous silica material has an X-ray diffraction pattern including at least one peak at a position of a diffraction angle (2θ) corresponding to a d value of at least 1 nm; and the composition is suitable for oral administration.