Patent ID: 7169931

Claim:
A pharmaceutical composition exhibiting thrombopoietin receptor agonism comprising at least one of a pharmaceutically acceptable excipient, binder, penetrant, disintegrator, lubricant, or carrier, and at least one compound according to formula (I), its prodrugs, pharmaceutically acceptable salts, or solvates: X 1 —Y 1 —Z 1 (I) wherein X 1 is wherein R 1 and R 2 are each independently chosen from a hydrogen atom, optionally substituted lower alkyls, carboxy, lower alkyloxycarbonyls, halogen atoms, optionally substituted aminocarbonyls, optionally substituted heteroaryls, and optionally substituted aryls; Y 1 is chosen from —NR A CO—(CR C R D ) O-2 , wherein R A is chosen from a hydrogen atom and lower alkyls; and R C and R D are each independently chosen from a hydrogen atom, halogen atoms, optionally substituted lower alkyls, optionally substituted lower alkyloxys, optionally substituted lower alkylthios, optionally substituted lower alkenyls, optionally substituted lower alkynyls, optionally substituted aryls, optionally substituted heteroaryls, optionally substituted cycloalkyls, optionally substituted aralkyls, optionally substituted heteroarylalkyls, optionally substituted non-aromatic heterocyclic groups, and optionally substituted amino groups; and Z 1 is wherein A 2 ring and B 2 ring are each independently chosen from a cyclic group optionally substituted with one or more substituent(s) chosen from substituent A group, wherein the cyclic group is chosen from C5–C7 cycloalkanes, C5–C7 cycloalkenes, and benzene rings, and substituent A group consists of lower alkyls, halogen atoms, halo(lower)alkyls, hydroxy, lower alkyloxys, halo(lower)alkyloxys, methylene, and oxo; R 4 is chosen from hydroxy, lower alkyloxys, and optionally substituted amino groups; n is an integer of 0 to 4; and broken line (---) represents the presence or absence of a bond.