Patent ID: 8648086

Claim:
A compound of Formula Ia, IIa, Ib, IIb, or Id, or a pharmaceutically acceptable salt thereof, wherein: L is O, S(O) n , N—R 2 , or alkylene which is optionally substituted with one or more independent R 3 groups; R 2 is H, alkyl, aryl, heteroaryl, —C(═O)-alkyl, —C(═O)-aryl, or —C(═O)-heteroaryl, each of which is optionally substituted with one or more independent Q 1 groups; L′ is a covalent bond, —C(═O)—, —C(═O)-alkylene, or alkylene, each of which is optionally substituted with one or more independent R 4 groups; A is wherein B, D, E, G, and J are each independently N or C—R 5 ; the 5-membered ring of A is connected to L and the 6-membered ring of A is connected to the urea group in Formula I or II; Ar is aryl or heteroaryl, and is optionally substituted with one or more independent R 6 groups; R 1 , R 3 , R 4 , R 5 , and R 6 are each independently H, halo, —CN, —CF 3 , —NO 2 , —NH 2 , —OH, —OCF 3 , —OCH 3 , —CO 2 H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, arylalkyl, or heteroarylalkyl, each of which is optionally substituted with one or more independent Q 2 groups; Q 1 and Q 2 are each independently H, halo, —CN, —CF 3 , —OCF 3 , —NO 2 , oxo, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, heterocycloaryl, —OR 7 , —S(O) n R 8 , —NR 9 R 10 , —SO 2 NR 9 R 10 , —C(O)R 11 , —C(O)NR 9 R 10 , —C(O)OR 12 , —OC(O)R 13 , —NR 9 C(O)R 11 , —NR 9 S(O) 2 R 14 , —NR 15 C(O)NR 9 R 10 , —NR 15 S(O) 2 NR 9 R 10 or—NR 15 S(O)NR 9 R 10 , each of which is optionally substituted with one or more independent H, halo, —CN, —OH, —NH 2 , —NO 2 , oxo, —CF 3 , —OCF 3 , —CO 2 H, —S(O) n H, alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, heterocycloaryl, or —O-alkyl, each of which may be partially or fully halogenated; R 7 , R 8 , R 11 , R 12 , R 13 , R 14 , or R 15 are each independently H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or heterocycloaryl; R 9 and R 10 are each independently H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or heterocycloaryl; or when in —NR 9 R 10 , R 9 and R 10 , together with the nitrogen atom to which they are attached, form a 3- to 12-membered saturated or unsaturated ring, wherein said ring optionally includes one or more heteroatoms each independently being O, N, or S(O) n ; n is 0, 1, or 2; and the R 1 groups in Formula Ia, IIa, Ib, IIb, or Id can be the same or different.