Patent ID: 8124604

Claim:
A compound of Formula I, wherein: R is H, —R 1 , —R 1 —R 2 —R 3 , —R 1 —R 3 , or —R 2 —R 3 ; R 1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, and is optionally substituted with R 1′ ; R 1′ is lower alkyl, hydroxy, lower hydroxyalkyl, lower alkoxy, halogen, nitro, amino, cycloalkyl, heterocycloalkyl, cyano, or lower haloalkyl; R 2 is —C(═O), —C(═O)O, —C(═O)N(R 2′ ), —(CH 2 ) q , or —S(═O) 2 ; R 2′ is H or lower alkyl; q is 1, 2, or 3; R 3 is H or R 4 ; R 4 is lower alkyl, lower alkoxy, lower heteroalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl, and is optionally substituted with one or more lower alkyl, hydroxy, oxo, lower hydroxyalkyl, lower alkoxy, halogen, nitro, amino, cyano, lower alkylsulfonyl, or lower haloalkyl; X is CH or N; Y 1 is H or lower alkyl; Y 2 is Y 2a or Y 2b ; Y 2a is H or halogen; Y 2b is lower alkyl, substituted with one or more Y 2b′ ; Y 2b′ is hydroxy, lower alkoxy, or halogen; each Y 2′ is independently Y 2′a or Y 2′b ; Y 2′a is halogen; Y 2′b is lower alkyl, optionally substituted with one or more Y 2′b′ ; Y 2′b′ is hydroxy, lower alkoxy, or halogen; n is 0, 1, 2, or 3; Y 3 is H, halogen, or lower alkyl, wherein lower alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, lower alkoxy, amino, and halogen; m is 0 or 1; Y 4 is Y 4a , Y 4b , Y 4c , or Y 4d ; Y 4a is H or halogen; Y 4b is lower alkyl, optionally substituted with one or more substituents selected from the group consisting of lower haloalkyl, halogen, hydroxy, amino, cyano and lower alkoxy; Y 4c is lower cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower haloalkyl, halogen, hydroxy, amino, and lower alkoxy; and Y 4d is amino, optionally substituted with one or more lower alkyl; or a pharmaceutically acceptable salt thereof.