Patent ID: 7705164

Claim:
A method of inhibiting metalloprotein activity in a mammal in need of therapy for a pathology, condition, or symptom associated with metalloprotein activity, which comprises administering an effective amount of a metalloprotein inhibitor of formula (IA) or (IB): wherein X is O or S and wherein R 1 is biphenylmethylcarbamly, phenoxyphenylcarbamyl, and biphenylcarbamyl, wherein any phenyl or aryl group can be independently substituted; and wherein R 2 is hydrogen, or is an unsubstituted (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl), (C 6 -C 10 )aryl, (C 6 -C 10 )aryl-(C 2 -C 10 )alkyl, and R 3 is hydrogen, or is an unsubstituted (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl or (C 1 -C 6 )alkanoyloxy, and R 4 , when present, is hydrogen, or is an unsubstituted (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl), (C 6 -C 10 )aryl, or (C 6 -C 10 )aryl-(C 2 -C 10 )alkyl; or a pharmaceutically acceptable salt thereof; the method comprising administering the effective amount of the inhibitor to the mammal.