Patent ID: 6867189

Claim:
A method of reducing body mass in an individual comprising administering to said individual a composition comprising a carrier and an Adipsin polypeptide comprising: a) amino acids 21-253 or 26-253 of SEQ ID NO: 2 and i) the amino acid at position 26 is Met: ii) the amino acid at position 52 is Gly; iii) the amino acid at position 59 is Gln; or iv) the amino acid at position 150 is Leu; or b) amino acids 20-253 or 26-253 of SEQ ID NO: 4 and i) the amino acid at position 26 is Met; ii) the amino acid at position 52 is Gly; iii) the amino acid at position 59 is Gln; or iv) the amino acid at position 150 is Leu; said composition further optionally comprising Apm1 (Adipose Most Abundant Gene Transcript 1) polypeptide.