Patent ID: 7208502

Claim:
A method of modulating an Edg-3 receptor mediated biological activity comprising contacting a cell expressing the Edg-3 receptor with an amount of a non-phospholipid modulator of the Edg-3 receptor sufficient to modulate the Edg-3 receptor mediated biological activity, wherein the modulator is a compound of Formula (VI): or a pharmaceutically acceptable solvate or hydrate thereof, wherein o is a member selected from the integers 0 to 4; each R 2 and R 4 is a member independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, acylamino, substituted acylamino, alkylamino, substituted alkylamino, alkylthio, substituted alkylthio, alkoxy, substituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, alkylarylamino, substituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylamino, substituted arylamino, arylsulfonyl, substituted arylsulfonyl, carboxy, carbamoyl, substituted carbamoyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, dialkylamino, substituted dialkylamino, heteroaryloxy, substituted heteroaryloxy, heteroaryl, substituted heteroaryl, heteroalkyl, and substituted heteroalkyl; and R 3 is a member independently selected from the group consisting of alkyl, substituted alkyl, acyl, substituted acyl, acylamino, substituted acylamino, alkylamino, substituted alkylamino, alkoxycarbonyl, substituted alkoxycarbonyl, alkylarylamino, substituted alkylarylamino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylamino, substituted arylamino, carbamoyl, substituted carbamoyl, dialkylamino, substituted dialkylamino, heteroaryl, substituted heteroaryl, heteroalkyl, and substituted heteroalkyl; and each R 5 is a member independently selected from the group consisting of alkyl, acyl, substituted acyl, acylamino, substituted acylamino, alkylamino, substituted alkylamino, alkylarylamino, substituted alkylarylamino, amino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylsulfonyl, substituted arylsulfonyl, azido, carboxy, carbamoyl, substituted carbamoyl, carboxyl, cyano, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, dialkylamino, substituted dialkylamino, halo, heteroaryl, substituted heteroaryl, hydroxyl, and nitro.