Patent ID: 8859620

Claim:
A compound of Formula II: wherein X is absent or (C 1 -C 24 )alkyene; Y is oxygen or sulfur; Z is carbon or nitrogen, provided that when Z is nitrogen, R 8 is absent; R 2 is hydrogen or halo; R 3 is hydrogen, halo, or —CONH(C 6 -C 20 )alkyl; R 4 and R 5 are each independently hydrogen, halo, or nitro; R 6 , R 7 , and R 11 are each independently hydrogen or (C 1 -C 4 )alkyl; R 8 is absent or hydrogen; R 9 is hydrogen, (C 1 -C 4 )alkyl, trifluoromethyl, or trifluoromethoxy; R 10 is hydrogen, halo, or —O(C 6 -C 20 )aryl; any (C 1 -C 24 )alkylene or (C 6 -C 20 )aryl is optionally substituted on carbon with one or more oxo, hydroxyl, halo, (C 6 -C 20 )aryl, nitro, cyano, (C 1 -C 6 )alkoxy, or trifluoromethyl groups or any combination thereof, and optionally exchanged on carbon with one or more oxo, imino, or thio groups; at least one of R 2 -R 11 is not hydrogen; a is 0, 1, or 2; and n is 0 or 1; or a pharmaceutically acceptable salt, as prodrug, or to metabolite thereof.