Patent ID: 8841282

Claim:
A method of treating or lessening the severity in a subject of acute, chronic, neuropathic, or inflammatory pain, visceral pain, osteoarthritis pain, radicular pain, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain, comprising administering an effective amount of a compound according to formula I: or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: ring Z is a thiazole or thiadiazole optionally substituted with 0-2 occurrences of R; V is O or S; and R, R 1 , R 2 , and R 3 are hydrogen, C1-C6 aliphatic, aryl, C3-C8 cycloaliphatic, halo, CN, NO 2 , CF 3 , OCF 3 , OH, NH 2 , NH(C1-C6 aliphatic), N(C1-C6 aliphatic) 2 , COOH, COO(C1-C6 aliphatic), O(C1-C6 aliphatic), CHF 2 , or CH 2 F; or a pharmaceutically acceptable composition comprising a compound of formula I to said subject in need thereof.