Patent ID: 8063225

Claim:
A compound according to formula 1, or a stereoisomer, tautomer, salt thereof: wherein: each W 1 through W 4 is independently a carbon atom or a nitrogen atom, wherein one of W 1 -W 4 is nitrogen, and W 5 and W 6 are carbon, with the proviso that when any W 1 through W 4 is N, then the corresponding substituent(s) X 1 through X 4 is (are) absent; each X 1 through X 3 is independently selected from hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, haloalkyl, trifluoromethyl, nitro, cyano, primary, secondary or tertiary amino; each X 5 and X 6 is independently selected from hydrogen and lower alkyl; X 4 is selected from hydrogen, halogen, or is selected from the following groups: wherein: m is an integer from 1 to 4, and n is an integer from 0 to 4; R 2 is selected from optionally substituted aryl, heteroaryl wherein said heteroaryl is imidazoyl, pyridinyl benzo-dioxanyl, benzo-dioxolyl, benzo-imidazolyl or indolyl, or —(CH 2 ) p -M 1 -aryl, substituted by substituents independently selected from a group consisting of hydrogen, lower alkoxy, aryloxy, benzyloxy, alkylthio hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, lower alkyl, lower alkenyl, methylenedioxy, trimethylene, cyano, nitro, tertiary amino, such as dimethylamino, carboxamide, lower alkylsulfonyl, lower alkylthio, optionally substituted aryl or heteroaryl, wherein M l is O, S, and p is an integer between 0 and 4; R 3 is selected from optionally substituted aryl, heteroaryl, wherein the heteroaryl is imidazoyl, pyridinyl benzo-dioxanyl, benzo-imidazolyl or indolyl, —(CH 2 ) 0 -aryl, or —(CH 2 ) 0 -heteroaryl, substituted by a substituent independently selected from a group consisting of hydrogen, lower alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, lower alkyl, cyano, nitro, primary, secondary or tertiary amino, carboxamide, optionally substituted aryl or heteroaryl, wherein o is 0 to 5; Y 1 is Y 2 is wherein: r is 1; and R 1 is independently selected from optionally substituted nitrogen containing heterocyclyl; nitrogen containing heterocyclylalkyl; wherein said heterocyclyl and heterocyclylalkyl are piperidinyl, pyrrolidinyl, piperazinyl, azetidinyl, morpholinyl, or quinucleodinyl; and nitrogen containing heteroarylalkyl, wherein substitutions are selected from: hydrogen, lower alkyl, hydroxy, lower alkoxy, amino, di-(lower alkyl)aminoalkyl carboxamido, sulfonamido, SO 2 -alkyl, SO-alkyl, CO-alkyl, CO 2 -alkyl, cyano, cyanoalkyl, ketoalkyl, and methanesulfonylalkyl.