Patent ID: 7888375

Claim:
A compound according to the structure of formula I: wherein the scaffold is independently the 2- and 4-pyridinones identified herein and their regioisomers; R 1 and R 2 are each independently H, C 1-6 alkyl, C 1-6 fluoroalkyl, unsubstituted or substituted C 5-6 cycloalkyl, C 1-6 alkenyl, unsubstituted or substituted phenyl, unsubstituted or substituted benzyl, C 2-6 alkyl phenyl which phenyl moiety may be optionally substituted, unsubstituted or substituted heteroaryl, C 1-6 alkyl substituted with a heteroaryl group which heteroaryl group is optionally substituted, C 1-6 alkyl S(O)R or alkyl (SO 2 )R where R is alkyl, phenyl or substituted phenyl, C 1-6 alkyl CO 2 R a where R a is C 1-6 alkyl or H, C 1-6 alkyl COR a′ where R a− is C 1-6 alkyl; R 3 and R 4 are independently selected from H, C 1-6 alkyl, halogen, hydroxyl, unsubstituted or substituted benzyl, or unsubstituted or substituted phenylthio; R 5 is CO 2 R c or P(O)(OR c )(OR c ), where each R c is independently from H and C 1-6 alkyl, Or a pharmaceutically acceptable salt thereof.