Patent ID: 8592611

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: n is independently an integer from 0 to 2; R 1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, perfluoroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl, wherein R 1 is optionally independently substituted with 1 to 5 R 2 groups; R 2 is independently hydrogen, halogen, nitro, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, perfluoroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, (CH 2 ) j CN, (CH 2 )OR 3 , (CH 2 ) q O(CH 2 ) j OR 3 , (CH 2 ) q O(CH 2 ) t O(CH 2 ) j OR 3 , (CH 2 ) q O(CH 2 ) t O(CH 2 ) u O(CH 2 ) j OR 3 , (CH 2 ) j C(O)R 3 , (CH 2 ) j C(O)OR 3 , (CH 2 ) j OC(O)R 3 , (CH 2 ) j NR 4 R 5 , (CH 2 ) j C(O)NR 4 R 5 , (CH 2 ) j OC(O)NR 4 R 5 , (CH 2 ) j NR 6 C(O)R 3 , (CH 2 ) j NR 6 C(O)OR 3 , (CH 2 ) j NR 6 C(O)NR 4 R 5 , —(CH 2 ) j S(O) m R 7 , (CH 2 ) j S(O) 2 NR 4 R 5 , (CH 2 ) j NR 6 S(O) 2 R 7 , or (CH 2 ) j OP(O)(OR 7 ) 2 , wherein q is independently an integer from 0 to 20, and j, t, and u are each independently an integer from 0 to 6, and each m is independently an integer from 0 to 2, wherein R 2 is optionally independently substituted with 1 to 5 R 8 groups; R 3 , R 4 , R 5 , R 6 , and R 7 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, perfluoroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl, or R 3 , R 6 , and R 7 are as described above, and R 4 and R 5 , together with the N atom to which they are attached, form substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl, wherein R 3 , R 4 , R 5 , R 6 , and R 7 are each optionally independently substituted with 1 to 5 R 8 groups; and R 8 is independently halogen, hydroxyl, cyano, nitro, alkyl, perfluoroalkyl, oxo, NH 2 , NH(alkyl), N(alkyl) 2 , O-alkyl, S-alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl.