Patent ID: 8372852

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt, or tautomer thereof: wherein represents a double bond between either A and B or B and D; A is —N═, or —NZ—; B is —CY═; D is —N═, —NW—; wherein W, Y and Z are each independently selected from H, F, Cl, Br, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, OC 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, OC 3 -C 6 cycloalkyl, phenyl or benzyl, wherein the alkyl, alkenyl, cycloalkyl, phenyl and the phenyl moiety of the benzyl group are optionally substituted with 1-3 substituents selected from F, Cl, Br, I, OH, CF 3 , C 1 -C 3 alkyl and OC 1 -C 3 alkyl; V is H, F, Cl, CN, CF 3 , SO 2 CH 3 , SO 2 NH 2 , SO 2 NHCH 3 , NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl); T is NH, O or S; R P is aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl; and R 1 , R 2 , R 3 and R 4 are independently selected from H, F, Cl, Br, I, CFH 2 , CF 2 H, CF 3 , CN, CH═CHCN, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, i-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, NH 2 , NHR′, NR′R″, OH, OR′, SH, SR′, C(O)R′, CO 2 H, COOR′, CONH 2 , CONHR′, CONR′R″, SO 3 H, S(O) 2 R′, S(O) 2 NH 2 , S(O) 2 NHR′, S(O) 2 NR′R″, aryl, heterocyclyl, heteroaryl; wherein R′ is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cyclopropylmethyl; R″ is methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cyclopropylmethyl; or R′ and R″ together with the nitrogen atom to which they are attached form an optionally substituted 4-, 5- or 6-membered heterocyclic ring; and the alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl moieties are optionally substituted with 1-3 substituents selected from F, Cl, Br, I, OH, NH 2 , CN, CF 3 and OC 1 -C 3 alkyl.