Patent ID: 7262176

Claim:
A compound of the formula: wherein: R 1 is lower alkyl of 1–6 carbon atoms, cycloalkyl of 3–6 carbon atoms, or phenyl optionally substituted by halo; X is a covalent bond or alkylene of 1–3 carbon atoms; R 2 is R 4 -Z-Y—C≡C— in which Y is alkylene of 1–3 carbon atoms, Z is oxygen, sulfur or —NH—, and R 4 is phenyl optionally substituted by halo or lower alkoxy; or R 2 is pyrazolyl optionally substituted by phenyl or benzyl, which are optionally substituted by halo, lower alkyl, or lower alkoxy, or; R 2 is pyrazolyl substituted by (lower alkyl)-O—C(O)—, —C(O)NH 2 , —C(O)NH-(lower alkyl), cycloalkyl of 3–6 carbon atoms, pyrimidinyl, pyridinyl, benzoxazolyl, quinazolyl, isoquinazolyl, or pryrazolyl, said pyrimidinyl, pyridinyl, benzoxazolyl, quinazolyl, isoquinazolyl, or pryrazolyl all of which are optionally substituted by 1, 2 or 3 lower alkyl groups; and R 3 is hydroxymethyl or —C(O)—NR 5 R 6 ; in which R 5 and R 6 are independently hydrogen or lower alkyl.