Patent ID: 8415382

Claim:
A composition comprising an amount of a compound of formula (I): wherein, X 1 and X 3 are selected from N and —NR 4 —, wherein R 4 is hydrogen or loweralkyl, provided that one of X 1 and X 3 must be N and the other of X 1 and X 3 must be —NR 4 —; X 2 is —NH— or —(CH 2 )hd m—, wherein m is 0, 1, 2, 3 or 4; A l is substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, or heteroarylheteroaryl; R 1 is hydrogen or substituted loweralkyl, or substituted or unsubstituted alkoxyalkyl, loweralkyloxy, amino, aminoalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocycloalkyl, heteroarylalkyl, cycloalkyloweralkyl, heterocycloalkyl -loweralkyl, loweralkylheterocycloalkyl, arylloweralkyl, heteroarylloweralkyl, alkyloxy -alkylheterocycloloweralkyl, or heteroarylloweralkyl; R 2 is hydrogen or loweralkyl; each R 3 and R 3 ′ are independently selected from hydrogen, halogen, hydroxy, cyano, loweralkyl, or loweralkoxy; and p and q are independently 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof that is effective to inhibit Raf kinase activity in a human or animal subject when administered thereto, together with a pharmaceutically acceptable carrier.