Patent ID: 8304560

Claim:
An aptamer conjugate prepared by conjugation of an aptamer to Dye I or its biological salts, wherein C is a non-conjugated chain of 10-50 linear atoms selected from the group consisting of carbon and nitrogen that are further substituted by one or more substituents selected from the group consisting of hydrogen, alkyl having 1-20 carbons, hydroxyl, carbonyl, and RGM; n is 0, 1, 2 or 3; R 1 , R 2 and R 3 are independently hydrogen, alkyl having 1-20 carbons, cycloalkyl having 3-20 carbons, aryl, heteroaryl, amino, alkylamino, arylamino, thiol, alkylthio or RGM; R 4 -R 11 and R 13 -R 16 are independently hydrogen, alkyl having 1-20 carbons, hydroxyl, alkoxy having 1-20 carbons, fluorinated alkyl, halogen, alkylthiol, sulfonyl, carbonyl, hydroxyl, amino, alkylthio, thiol, sulfate, phosphonate or RGM; RGM is a carboxylic acid, an activated ester of a carboxylic acid, an acyl azide, an acyl nitrile, an imido ester, an isocyanate, an isothiocyanate, or a maleimide.