Patent ID: 7923446

Claim:
A method for modulating the activity of a metalloproteinase comprising contacting said metalloproteinase with an effective amount of a compound of formula I: wherein: R 1 is H or C 1 -C 6 alkyl; R 2 is H, C 1 -C 6 alkyl, (CH 2 ) n R 2′ , phenyl, or benzyl; n is 0-6; R 2′ is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 3 is, independently with respect to each occurrence, H, halogen, OC(halogen) 3 , C(halogen) 3 , alkoxy, or C 1 -C 6 alkyl; X is selected from CH 2 O, OCH 2 , C(R 3 )═C(R 3 ), C(R 3 ) 2 —C(R 3 ) 2 , CH 2 NHC(═O), O(C═O)NH, O, C(═O)CH 2 , SO 2 CH 2 C(═O)NH, SO 2 NH, OC(═O), CH 2 S(O), and CH 2 S(O) 2 ; and Z is at least one aryl or heteroaryl moiety.