Patent ID: 7166589

Claim:
A compound of formula I or a pharmaceutically acceptable salt or ester thereof wherein formula I is: wherein: R 1 is —O—R 4 or —NR 5 R 6 ; R 2 is hydrogen, alkyl, cycloalkyl, alkoxy, halogen, heterocyclyl or amino; R 3 is hydrogen, alkyl, amino or halogen; R 4 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, alkoxyalkyl, hydroxyalkyl or heterocyclyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, alkoxyalkyl, hydroxyalkyl and heterocyclyl; or R 5 and R 6 together with the N atom to which they are attached form a 5- to 10-membered heterocyclic ring optionally containing a second heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, wherein the heterocyclyc ring is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and alkoxy; A 1 is a diazepine ring optionally substituted by one to three substituents independently selected from the group consisting of alkyl, alkoxy, hydroxy, hydroxyalkyl, alkoxyalkyl, amino, acetylamino, cyano, tetrahydropyranyloxyalkyl and cycloalkylalkoxy and cycloalyklalkoxy; and A 2 is —CH 2 — or —C(O)—.