Patent ID: 8415386

Claim:
A compound of Formula I or a pharmaceutically acceptable salt or a stereoisomer thereof: wherein is a monocyclic aryl or monocyclic heteroaryl; W is a direct bond, —O—, or —N(R 6 )—, provided that if W is a direct bond, D must be a cyclic amine that is attached to A via the nitrogen atom of said cyclic amine; D is a direct bond, substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, cycloalkylalkyl, or a 4 to 6 membered cyclic amine; B and E are independently N or CH provided that both are not CH; R 1 is substituted or unsubstituted phenyl, substituted or unsubstituted pyridyl, or substituted or unsubstituted thienyl; R 2a , R 2b , and R 2c are independently selected from the group consisting of hydrogen, halo, cyano, hydroxyl, —NR 5 R 5a, —OSO 2 R 34 , —NR 5 CO 2 R 21 , —NR 5 COR 21 , —CO 2 R 35 , substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, a substituted or unsubstituted 4 to 6 membered cyclic amine wherein said cyclic amine is optionally substituted with —OH; carbonylamino, alkoxycarbonylamino; a prodrug moiety selected from amino acid esters or phosphoric acid esters wherein said amino acid ester is of the formula —OC(O)CH(NH 2 )R 31 ; or any two of R 2a , R 2b , or R 2c , may be taken together to form a cycloalkyl or a cyclic amine; provided that if D is a direct bond, R 2a , R 2b and R 2c are each independently H, alkyl, or cycloalkyl; R 3 and R 3a are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkoxy, halo, CN, substituted or unsubstituted C 1 to C 4 alkyl, perfluoroalkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, and cycloalkoxy; or R 3 and D or R 3a and D may optionally be taken together with the atoms to which they are attached to form a 5- to 7membered ring; R 5 and R 5 a are the same or different and are independently selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl, hydroxyalkyl, hydroxyalkylcycloalkyl, substituted or unsubstituted heterocycloalkyl, acyl, alkoxycarbonyl, carboxyalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, and substituted or unsubstituted cycloalkoxyalkyl wherein the R 5 and R 5a groups and the N atom to which they are attached may form a ring; R 31 is H or C 1 to C 4 alkyl; R 21 and R 34 are alkyl; R 35 is H or alkyl; and R 6 is selected from the group consisting of H, C 1 to C 4 alkyl and C 3 to C 7 cycloalkyl, provided that (1) when R l is B is CH, E is N, is is R 3 is OCH 3 , and W is O, then is other than CH 3 ; (2) when R 1 is B is N, E is CH, is R 3 is H, and W is O, then is other than