Patent ID: 7435585

Claim:
A method for auto-stimulating a cell comprising: coating the surface of said cell with a first protein, wherein said first protein is a lipidated protein; and contacting said cell with a second protein, wherein said second protein is a fusion protein having a first domain having affinity for said lipidated protein and a second domain that binds to a receptor on said cell's surface and engenders a change in the physiological state of said cell, wherein the cell is selected from the group consisting of a T-cell, a tumor-infiltrating lymphocyte, a lymphokine-activated killer cell, a monocyte, a natural killer cell, a neutrophil, an eosinophil, a basophil, a mast cell, a keratinocyte, an endothelial cell, an islet cell, a fibroblast, an osteoblast, a chondrocyte, a muscle cell, a neural cell and a stem cell.