Patent ID: 8354399

Claim:
A compound of formula (I) Ar is aryl or heteroaryl substituted with Ra and Rb, wherein Ra is NO 2 , NH 2 , NH-G, N-(E)-G, O-G′, (CH 2 ) n -A or CH 2 -Hal and Rb is hydrogen, halogen, NO 2 , NH 2 , NH-G, NH—CO-L, O-E or E, wherein Hal is halogen, A is optionally substituted heterocyclyl, E is straight or branched unsubstituted C 1 -C 6 alkyl, G is straight or branched substituted C 1 -C 6 alkyl or an optionally substituted heterocyclyl, G′ is straight or branched C 1 -C 6 alkyl substituted with N(C 1 -C 6 alkyl) 2 , or an optionally substituted heterocyclyl, and L is optionally substituted heteroaryl; Ar′ is an optionally substituted aryl or heteroaryl; R1, R2 and R3 are independently hydrogen, halogen, nitro, an optionally substituted straight or branched C 1 -C 6 alkyl, NR4R5 or OR6, wherein R4 and R5 are independently hydrogen, alkenyl, alkynyl, R8R9N—C 2 -C 6 alkyl, R8O—C 2 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, aryl or heteroaryl, or R4 and R5, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted heterocyclyl group; R6 is hydrogen, alkenyl, alkynyl, COR7, SOR10, SO 2 R10, R8R9N—C 2 -C 6 alkyl, R8O—C 2 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, aryl or heteroaryl; R7 is hydrogen, alkenyl, alkynyl, NR4R5, OR6, SR6, R8R9N—C 1 -C 6 alkyl, R8O—C 1 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein R4, R5 and R6 are defined as above; R8 and R9 are independently hydrogen, alkenyl, alkynyl, COR7, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, aryl or heteroaryl, or R8 and R9, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted heterocyclyl group, wherein R7 is as defined above; R10 is hydrogen, alkenyl, alkynyl, NR4R5, OR6, R8R9N—C 1 -C 6 alkyl, R8O—C 1 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein R4, R5, R6, R8 and R9 are as defined above; R′ and R″ are each independently hydrogen or an optionally substituted straight or branched C 1 -C 6 alkyl; n is 0 or 1, and pharmaceutically acceptable salt thereof.