Patent ID: 8247557

Claim:
A compound of formula (I) wherein X 1 and X 2 are o; Y is CH 2 ; Z 1 is S, SO or SO 2 , Z 2 , Z 3 and Z 4 are independently CQ or N; Q is H, halogen, hydroxyl, carboxyl, amino, nitro, cyano, alkyl, aryl, phenyl, a carbocycle, or a heterocycle optionally substituted with halogen, amino, oxo, alkyl, aryl, phenyl, a carbocycle or a heterocycle; wherein one or more CH 2 groups of an alkyl is optionally replaced with —O—, —S—, —S(O)—, S(O) 2 , —N(R 8 )—, —C(O)—, —C(O)—NR 8 —, —NR 8 —C(O)—, —SO 2 —NR 8 —, —NR 8 —SO 2 —, —NR 8 —C(O)—NR 8 —, —NR 8 —C(NH)—NR 8 —, —NR 8 —C(NH)—, —C(O)—O— or —O—C(O)—; and said alkyl, aryl, phenyl, carbocycle or heterocycle is optionally substituted with one or more hydroxyl, alkoxy, acyl, halogen, mercapto, oxo, carboxyl, acyl, halo-substituted alkyl, amino, cyano, nitro, amidino, guanidino, alkoxy, alkoxyalkoxy, hydroxyalkoxy, alkylthio, acyloxy, acyloxyalkoxy, alkylsulfonyl, alkylsulfonylalkyl, alkylsulfinyl, alkylsulfinylalkyl, an optionally substituted aryl, phenyl, or carbocycle, or an optionally substituted heterocycle; R 1 is H; R 2 is alkyl, aryl, phenyl, a carbocycle, carbocyclylalkyl, a heterocycle or heterocyclylalkyl each optionally substituted with halogen, hydroxyl, oxo, thione, mercapto, carboxyl, alkyl, haloalkyl, acyl, alkoxy, alkylthio, sulfonyl, amino and nitro, wherein said alkyl, acyl, alkoxy, alkylthio and sulfonyl are optionally substituted with hydroxy, mercapto, halogen, amino, alkoxy, hydroxyalkoxy or alkoxyalkoxy; R 3 is H or alkyl optionally substituted with halogen or hydroxyl; or R 3 and R 4 together form a 3-6 member heterocycle; R 3 ′ is H, or R 3 and R 3 ′ together form a 3-6 member aryl, phenyl, or carbocycle; R 4 and R 4 ′ are independently H or alkyl, wherein alkyl is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino, imino or nitro; R 5 is H or alkyl; R 6 and R 6 ′ are H; R 8 is H, alkyl, aryl, phenyl, a carbocycle or a heterocycle wherein one or more CH 2 groups of said alkyl is optionally replaced with —O—, —S—, —S(O)—, S(O) 2 , —N(R 8 ), or —C(O)—; and said alkyl, aryl, phenyl, carbocycle and heterocycle is optionally substituted with hydroxyl, alkoxy, acyl, halogen, mercapto, oxo (═O), carboxyl, acyl, halo-substituted alkyl, amino, cyano, nitro, amidino, guanidino, an optionally substituted aryl, phenyl, or carbocycle, or an optionally substituted heterocycle; and n is 0 to 4; and salts thereof.