Patent ID: 6884816

Claim:
A method of controlling normal or elevated intraocular pressure or glaucoma comprising administering to a patient a pharmaceutically effective amount of a composition comprising at least one compound of Formula I: wherein R 1 and R 2 are hydrogen; or R 1 is a hydrogen or a substituted or unsubstituted alkyl group when R 2 and R 3 are part of a heterocycle; R 3 and R 4 are independently chosen from hydrogen, C 1-4 alkyl, or R 3 , R 4 and the carbon atom to which they are attached form a cyclopropyl ring, or R 2 and R 3 together represent (CH 2 ) m and with the nitrogen linked to R 2 to form pyrrolidine; R 5 is chosen from hydrogen, halogen, or a substituted or unsubstituted alkyl group; R 6 -R 9 are independently chosen from hydrogen, halogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, or hydroxyl wherein at least one of R 6 -R 9 is a hydroxyl; A is CH 2 CH 2 , CH═CH, or CR 10 R 11 ; X is N; R 10 and R 11 are independently hydrogen, a substituted or unsubstituted alkyl group, or halogen; m is 3; or pharmaceutically acceptable salts or solvates thereof.