Patent ID: 7390875

Claim:
A process for coupling, in solution, between at least one peptide compound and at least one lipophilic vector bearing an aldehyde function, said coupling including a step of forming a hydrazone bond between said peptide compound and said lipophilic vector, wherein said lipophilic vector is of a non-peptide type and corresponds to the following formula (I): [(R 1 ) (R 2 ) i ]D—CHO (I) wherein: i represents 0 or 1, if i is equal to 0, D represents a bond, if i is equal to 1, D represents a mono- or polycyclic saturated, unsaturated or aromatic heterocycle, and R 1 and R 2 , which may be identical or different, each represent a group having the formula L-f-E-f′ where L represents a residue of a lipid, B represents a spacer arm, and f and f′ represent functions binding, respectively, L to E and B to D.