Patent ID: 7294718

Claim:
A method of preparing a compound represented by Structural Formula (VII): comprising the steps of: a.) protecting 2,4-dihydroxybenzoic acid with protecting groups, thereby forming protected benzoic acid represented by Structural Formula (II): wherein R 1 and R 2 are each independently a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted arylalkyl group; b.) reacting a chlorinating agent and the protected benzoic acid, wherein R 1 and R 2 are as defined above, thereby forming a protected benzoyl chloride represented by Structural Formula (III): c.) reacting the protected benzoyl chloride with ammonia or a salt thereof, thereby forming a protected benzamide represented by Structural Formula (IV): d.) reacting the protected benzamide with a trialkyloxonium hexafluorophosphate of the formula (R 3 ) 3 OPF 6 , wherein R 3 is a substituted or unsubstituted alkyl group, thereby forming a protected benzimidate represented by Structural Formula (VI): e.) deprotecting the protected benzimidate, thereby forming the 2,4-dihydroxybenzimidate; and f.) coupling the 2,4-dihydroxybenzimidate and (S)-2-methylcysteine, thereby forming the compound represented by Structural Formula (VII).