Patent ID: 7884102

Claim:
A compound according of formula I: wherein: R 1 is —C(═O)OR 5 , —C(═O)NR 6 R 7 , or —NR 6 R 7 ; R 2 and R 3 are each independently alkyl or alkenyl; R 4 is: H, cycloalkyl, heterocycloalkyl, or C 1-10 alkyl which is substituted with at least one: substituted aryl, wherein at least one of said aryl substituents is other than OH, nitro, amino, halo, CN, CH 2 CN, CONH 2 , C 1-4 alkyl, C 1-4 alkoxy, or C 1-5 alkanoyl (which latter three groups are optionally substituted by one or more halo atoms), aryloxyaryl, -aryl-N(H)R b , -aryl-N(R b )R b , heteroarylaryl, alkoxyaryl, wherein the carbon chain of said alkoxy is interrupted by a nitrogen atom, substituted alkoxyaryl, provided that when one or more substituents are present on the alkoxy group, at least one of said substituents is other than halo, substituted cycloalkyl, RS(═O) p substituted heteroaryl, RS(═O) p substituted heterocycloalkyl, RS(═O) p substituted aryl, heterocycloalkylheteroaryl, heteroarylheteroaryl, bicycloalkyl, bicycloalkenyl, carboxy, —CO 2 R a , —C(═O)N(R 6a )—R 6b —CO 2 H, —C(═O)N(R 6a )—R 6b —CO 2 R, —C(═O)N(R 6a )—R 6b —C(═O)NR 7a R 7b , —N(R 7c )C(═O)R 7d , —N(R 7c )S(═O) 2 R 7d , aralkoxyaryl, substituted arylheteroaryl, or substituted alkoxyheteroaryl, provided that when one or more substituents are present on the alkoxy group, at least one of said substituents is other than halo; p is 0, 1, or 2; R is alkyl, aralkyl, or aryl; R a is H, alkyl, alkenyl, cycloalkyl, aryl, or heteroaryl, provided that R a is not C 1-6 alkyl; each R b is independently alkyl, cycloalkyl, aralkyl, or aryl, R 6a is H, alkyl, aralkyl, cycloalkyl, alkenyl, aryl, heteroaralkyl, or heteroaryl; R 6b is lower alkylene, or lower aralkylene or, together with the nitrogen atom to which they are attached, R 6a and R 6b form a 4- to 7-membered heterocycloalkyl ring; R 7a and R 7b are each independently H, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, aralkyl, or aryl, or together with the nitrogen atom to which they are attached, R 7a and R 7b form a 4- to 7-membered heterocycloalkyl ring, provided that at least one of R 7a and R 7b is other than H; R 7c and R 7d are each independently H, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, aralkyl, or aryl; R 5 is H or alkyl; and each R 6 and R 7 is independently H, alkyl, or —C(═O)R, or, together with the nitrogen atom to which they are attached, R 6 and R 7 form a 4- to 7-membered heterocycloalkyl ring, provided that no more than one of R 6 and R 7 is —C(═O)R, and provided that when R 1 is NR 6 R 7 , R 4 can also be aralkyl; provided that when R 4 is H and R 2 and R 3 are each independently alkyl, then R 1 is —C(═O)NR 6 R 7 or —NR 6 R 7 , wherein at least one of R 6 and R 7 is —C(═O)R, or, R 6 and R 7 taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocycloalkyl ring; or a stereoisomer, pharmaceutically acceptable salt, or N-oxide thereof, provided that R 2 and R 3 are not in the cis stereoisomer conformation when both R 2 and R 3 are methyl.