Patent ID: 8309124

Claim:
A method of administering a glucocorticosteroid active substance selected from prednisone, prednisolone, and methylprednisolone to a patient in need thereof comprising administering to the patient a dosage form comprising a core and a coating surrounding the core, wherein the core comprises the glucocorticosteroid active substance and further comprises at least one disintegrating agent that, upon exposure to aqueous media, provides a force to rupture the coating, wherein the coating comprises at least one insoluble or poorly water soluble hydrophobic material such that the glucocorticosteroid active substance is released from the core as a result of the rupturing of the coating and not as a result of the glucocorticosteroid active substance diffusing through the coating, provided that the coating does not include an insoluble or poorly water soluble hydrophobic material that is a polymer, and wherein the coating ruptures upon immersion in an aqueous medium, regardless of pH of the aqueous medium, after a period of between about 2 to about 6 hours to release the glucocorticosteroid active substance, and provided that the dosage form does not comprise a further enteric coating.