Patent ID: 7790856

Claim:
A humanized antibody, or fragment thereof, comprising a humanized light chain comprising three light chain complementarily determining regions (CDRs) from the mouse monoclonal antibody 10D5 and a light chain variable region framework sequence from a human immunoglobulin light chain; and a humanized heavy chain comprising three heavy chain CDRs from the mouse monoclonal antibody 10D5 and a heavy chain variable region framework sequence from a human immunoglobulin heavy chain; wherein the light chain CDRs have the following amino acid sequences: light chain CDR1: Arg Ser Ser Gln Asn Ile Ile His Ser Asn Gly Asn Thr Tyr Leu Glu (residues 24-39 of SEQ ID NO: 14) light chain CDR2: Lys Val Ser Asn Arg Phe Ser (residues 55-61 of SEQ ID NO: 14) light chain CDR3: Phe Gln Gly Ser His Val Pro Leu Thr (residues 94-102 of SEQ ID NO: 14) and the heavy chain CDRS have the following amino acid sequences: heavy chain CDR1: Thr Ser Gly Met Gly Val Ser (residues 31-37 of SEQ ID NO: 16) heavy chain CDR2: His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser (residues 52-67 of SEQ ID NO: 16) and, heavy chain CDR3: Arg Pro Ile Thr Pro Val Leu Val Asp Ala Met Asp Tyr (residues 100-112 of SEQ ID NO: 16).