Patent ID: 6953801

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof, wherein: V is a bond or —(C═O)—; W is N; X is selected from halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; Y and Z are each CH; n is 1; R 1 and R 2 are each independently selected from hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; with the proviso that if R 1 and R 2 are hydrogen, then V is —C═O)—; R 3 is joined with R 6 to form a heterocyclic group having 5 or 6 ring members, with one ring member being nitrogen and remaining ring atoms being carbon, wherein the heterocyclic group is substituted with 0, 1 or 2 substituents independently chosen from hydrogen, halogen, cyano, hydroxy, oxo, oxime, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkanoyl, C 1 -C 6 alkanoyloxy, C 1 -C 6 alkoxycarbonyl, halo(C 1 -C 6 )alkyl and halo(C 1 -C 6 )alkoxy; R 4 is hydrogen, (C 1 -C 6 )alkyl or halo(C 1 -C 6 )alkyl; R 5 is independently selected at each occurrence from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, mono- and di(C 1 -C 6 )alkylamino, and amino(C 1 -C 6 )alkyl; R 7 is: (i) selected from hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; or (ii) joined with R 8 or R 12 to form a fused phenyl ring; R 8 is: (i) selected from hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; or (ii) joined with R 7 or R 11 to form a fused phenyl ring; U is CR 9 ; T is CR 10 ; R 9 is: (i) selected from hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; or (ii) joined with R 10 or R 11 to form a fused phenyl ring; R 10 is: (i) selected from hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; or (ii) joined with R 3 , R 8 or R 9 to form a fused phenyl ring; R 11 is: (i) selected from hydrogen, halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy; or (ii) joined with R 8 or R 9 to form a fused phenyl ring; R 12 is: (i) independently selected at each occurrence from hydrogen, halogen, hydroxy, nitro, cyano, amino, oxo, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, mono- and di(C 1 -C 6 )alkylamino, and amino(C 1 -C 6 )alkyl; or (ii) joined with R 7 to form a fused phenyl ring.