Patent ID: 8722699

Claim:
A compound of Formula (I) or (II): or ion pairs, salts, hydrates or solvates thereof, wherein: R 1 is hydrogen, (C 1 -C 4 ) alkyl, substituted (C 1 -C 4 ) alkyl or (C 1 -C 4 ) alkyl substituted with one or more fluorine atoms; R 2 is alkyl, substituted alkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, —NO 2 , —N 3 , —OH, —S(O) k R 100 , —OR 101 , —NR 102 R 103 , —CONR 104 R 105 , —CO 2 R 106 or —O 2 CR 107 ; R 3 is hydrogen, (C 1 -C 3 ) alkyl, (C 1 -C 3 ) substituted alkyl or (C 1 -C 3 ) alkyl substituted with one or more fluorine atoms; R 4 is hydrogen, methyl, ethyl, substituted aryl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, —OR 108 , —NR 109 R 110 , R 5 is (C 1 -C 4 ) alkyl or (C 1 -C 4 ) substituted alkyl; R 6 is hydrogen, (C 1 -C 4 ) alkyl, substituted (C 1 -C 4 ) alkyl, benzyl or substituted benzyl; R 7 is (C 1 -C 4 ) alkyl, substituted (C 1 -C 4 ) alkyl, benzyl or substituted benzyl; R 8 is hydrogen, OH, ═O, (C 1 -C 4 ) alkyl, (C 1 -C 4 ) substituted alkyl, —CO 2 R 114 or —CONR 115 R 116 ; R 9 is hydrogen, OH, ═O, (C 1 -C 4 ) alkyl, (C 1 -C 4 ) substituted alkyl, —CO 2 R 117 or —CONR 118 R 119 ; R 10 is hydrogen, OH, ═O, (C 1 -C 4 ) alkyl, (C 1 -C 4 ) substituted alkyl, —CO 2 R 120 or —CONR 121 R 122 ; R 11 is hydrogen, (C 1 -C 3 ) alkyl or (C 1 -C 3 ) alkyl substituted with one or more fluorine atoms; R 12 is hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —S(O) m R 111 or —CONR 112 R 113 ; R 100 -R 122 are independently hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; m and k are independently 0, 1 or 2; n is 0, 1, 2 or 3; and provided that when R 11 is hydrogen or (C 1 -C 3 ) alkyl, R 1 is (C 1 -C 4 ) alkyl substituted with one or more fluorine atoms; and R 109 and R 110 are not substituted with fluorine unless R 12 is acyl or substituted acyl.