Patent ID: 8153619

Claim:
A compound having the formula (V): or a pharmaceutically acceptable salt or conjugate thereof; wherein R 1 is H, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C6 aryl, C6-C12 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; R 2 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, C6-C14 arylalkyl, C6-C14 heteroarylalkyl, each of which may be optionally substituted; or R 1 and R 2 may be taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member; R 8 and R 9 are independently H, halo, or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C12 aryl, C5-C12 heteroaryl, each of which may be optionally substituted, or COOR 11 or CONR 11 2 , where each R 11 is independently H or C1-C4 alkyl; m and m″ are independently 0-3; and each Y and Y″ is independently halo, OH, C1-C4 alkoxy, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, or C6-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; Z is OH, OR, CH 2 OR, SR, or NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl; and R 10a and R 10b are taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl ring, which may be optionally substituted.