Patent ID: 7235532

Claim:
A method of inducing angiogenesis in vivo, comprising administering to a patient in need thereof, an angiogenesis inducing effective amount of a compound of formula I: in which the compound of formula I is a tetrapeptide or tripeptide and in which, A 1 is CH 2 OH, A 2 is CH 2 COOH or CH 2 —CH 2 —COOH, A 3 is (CH 2 ) 4 —NH 2 , (CH 2 ) 3 —NH—C(NH)NH 2 , or (CH 2 ) 3 —NH 2 , A 4 is a radical corresponding to D- or L-Pro when the compound of formula I is a tetrapeptide, R 1 and R 2 are independently selected from H, C 1 –C 12 -alkyl which may be optionally substituted, C 7 –C 20 -arylalkyl which may be optionally substituted, R 4 CO or R 4 COO, R 4 being C 1 –C 12 -alkyl which may be optionally substituted, or C 7 –C 20 -arylalkyl which may be optionally substituted, X 1 and X 2 are peptide or pseudopeptide bonds, X 3 is CO or CH 2 when the compound of formula I is a tetrapeptide, or a bond when the compound of formula I is a tripeptide, and R 3 is OH, NH 2 , C 1 –C 12 -alkoxy or NH—X 4 —CH 2 -Z, X 4 is a straight or branched C 1 –C 12 hydrocarbon, and Z is H, OH, CO 2 H or CONH 2 , or a pharmaceutically acceptable salt thereof.