Patent ID: 8653257

Claim:
A method of making 2-fluoro-11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine, said method comprising: reacting 5-fluoro-2-mercapto-benzoic acid ethyl ester with 1-fluoro-2-nitrobenzene to form 5-fluoro-2-(2-nitro-phenylsulfanyl)-benzoic acid ethyl ester; converting 5-fluoro-2-(2-nitro-phenylsulfanyl)-benzoic acid ethyl ester to 5-fluoro-2-(2-amino-phenylsulfanyl)-benzoic acid ethyl ester; cyclizing 5-fluoro-2-(2-amino-phenylsulfanyl)-benzoic acid ethyl ester to form 2-fluoro-10H-dibenzo[b,f][1,4]thiazepin-11-one; converting 2-fluoro-10H-dibenzo[b,f][1,4]thiazepin-11-one to 11-chloro-2-fluoro-dibenzo[b,f][1,4]thiazepine, and reacting 11-chloro-2-fluoro-dibenzo[b,f][1,4]thiazepine with piperazine to form 2-fluoro-11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine.