Patent ID: 8647625

Claim:
An antibody, or antigen-binding fragment thereof, that binds to CD154 and that comprises a light chain variable region and a heavy chain variable region, wherein (i) the light chain variable region sequence comprises light chain CDRs LC CDR1, LC CDR2, and LC CDR3 and comprises (a) an amino acid sequence of SEQ ID NO:1 or (b) an amino acid sequence that has at least 95% sequence identity with SEQ ID NO:1 and that differs in the light chain CDRs from SEQ ID NO:1 by one or a combination of substitutions selected from the group consisting of T33W, S26D, Q27E; and (ii) the heavy chain variable region sequence comprises heavy chain CDRs HC CDR1, HC CDR2, and HC CDR3 and comprises (a) an amino acid sequence of SEQ ID NO:4 or (b) an amino acid sequence that has at least 95% sequence identity with SEQ ID NO:4 and that differs in the heavy chain CDRs from SEQ ID NO:4 by one or a combination of substitutions selected from the group consisting of T30H, Y33W, S54N; wherein when the light chain variable region sequence comprises SEQ ID NO:1, the heavy chain variable region sequence does not comprise SEQ ID NO:4.