Patent ID: 7226950

Claim:
A compound of formula (III): wherein: A 6 and A 7 are each independently alkylene or substituted alkylene; each R 20 is independently halo, alkyl, substituted alkyl, aryl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, trifluoromethyl, cyano, nitro, hydroxy, NR 4 R 5 , or CO 2 R 6 ; R 21 is hydrogen, alkyl, or substituted alkyl; each R 22 is independently halo, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, trifluoromethyl, cyano, nitro, hydroxy, NR 4 R 5 , or CO 2 R 6 ; y is 0, 1, 2, 3, 4, or 5; z is 0, 1, 2, 3, 4, or 5; and R 4 –R 6 are each independently hydrogen, alkyl, or substituted alkyl; wherein any aryl of A 6 , A 7 , R 20 –R 22 and R 4 –R 6 can optionally be substituted with from 1 to 5 substituents R g ; wherein each R g is independently selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, cycloalkoxy, substituted cycloalkoxy, methanediol, ethanediol, cycloalkyl, substituted alkoxy, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxy, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, heteroaryl and trihalomethyl; and wherein any heteroaryl of A 6 , A 7 , R 20 –R 22 and R 4 –R 6 can be optionally substituted with 1 to 5 substituents R h , wherein each R h is independently selected from the group consisting of hydroxy, alkyl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, substituted alkyl, arylalkyl, heteroarylalkyl, heterocyclealkyl, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxyl, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, heterocyclic, and trihalomethyl; or a pharmaceutically acceptable salt thereof.