Patent ID: 8629117

Claim:
A composition comprising a) an oligonucleotide having a sequence according to SEQ ID NO: 9, unmodified or having one or more modifications selected from the group consisting of phosphorothioate internucleotide linkages, methylphosphonate internucleotide linkages, phosphoramidite linkages, peptide linkages, 2′-O-modified sugar, and modified bases, which oligonucleotide reduces the expression of transforming growth factor (TGF)-β 1 , TGF-β 2 , and TGF-β 3 , in combination with b) at least one stimulator positively effecting an immune response by enhancing proliferation or function of immune cells and selected from the group consisting of Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), Stem Cell Factor (SCF), Colony Stimulating Factor (CSF), Interferon (IFN), FMS-Related Tyrosine Kinase 3 Ligand (FLT-3-ligand), interleukin-4, interleukin-12, and interleukin 18.