Patent ID: 8852630

Claim:
A method of treating prostate cancer in a patient in need thereof comprising administering to said patient an effective amount of a compound according to the chemical structure: wherein A is an antibody binding moiety according to the chemical formula: Y′ is H or NO 2 ; X is O, CH 2 , NR 1 , S(O), S(O) 2 , —S(O) 2 O, —OS(O) 2 , or OS(O) 2 O; R 1 is H, a C 1 -C 3 alkyl group, or a —C(O)(C 1 -C 3 ) group; X′ is CH 2 , O, N—R 1′ or S; R 1′ is H or C 1 -C 3 alkyl; Z is a bond, a monosaccharide, disaccharide, oligosaccharide, glycoprotein or glycolipid; X b is a bond, O, CH 2 , NR 1 or S; X″ is O, CH 2 , NR 1 ; R 1 is H, a C 1 -C 3 alkyl group or a —C(O)(C 1 -C 3 ) group; n is 1 or 2; n 1 is 1; B is a cell binding moiety according to the chemical formula: Where X 1 and X 2 are each independently CH 2 , O, NH or S; X 3 is O, CH 2 , NR 1 , S(O), S(O) 2 , —S(O) 2 O, —OS(O) 2 , or OS(O) 2 O; R 1 is H, a C 1 -C 3 alkyl group, or a —C(O)(C 1 -C 3 ) group; k is an integer from 0 to 20; L is a linker according to the chemical formula: Or a polypropylene glycol or polypropylene-co-polyethylene glycol linker having between 1 and 100 glycol units; Where R a is H, C 1 -C 3 alkyl or alkanol or forms a proline side chain with R 3 ; R 3 forms a proline side chain with R a or is a side chain derived from an amino acid wherein said amino acid is selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine and valine; and m is an integer from 1 to 45, or L is a linker according to the chemical formula: Where Z and Z′ are each independently a bond, —(CH 2 ) i —O, —(CH 2 ) i —S, —(CH 2 ) i —N—R, wherein said —(CH 2 ) i group, if present in Z or Z′, is bonded to [CON] if present, antibody binding terminus (ABT) or cell binding terminus (CBT); Each R is independently H, or a C 1 -C 3 alkyl or alkanol group; Each R 2 is independently H or a C 1 -C 3 alkyl group; Each Y is independently a bond, O, S or N—R; Each i is independently 0 to 100; D is or a bond, with the proviso that Z, Z′ and D are not each simultaneously bonds; j is 1 to 100; m′ is 1 to 100; n′ is 1 to 100; and X 1 is O, S or N—R, R is as defined above; and [CON] is a bond or a moiety according to the chemical structure: Where X 2 is O, S, NR 4 , S(O), S(O) 2 , —S(O) 2 O, —OS(O) 2 , or OS(O) 2 O; X 3 is NR 4 , O or S; and R 4 is H, a C 1 -C 3 alkyl or alkanol group, or a —C(O)(C 1 -C 3 ) group; or a pharmaceutically acceptable salt thereof.