Patent ID: 7659278

Claim:
A method of treating a mutant p53 mediated cancer selected from the group consisting of osteosarcoma, lung adenocarcinoma, Burkitt lymphoma, ovarian carcinoma and colon carcinoma, comprising: administrating to a mammal in need thereof a pharmaceutically efficient amount of a compound selected from compounds having a structure according to the formula I wherein: R1 is hydrogen or a methylene group, which can be double bonded, as indicated by the broken line, or single bonded and linked to the nitrogen atom of an amine-substituted phenyl group, to a nitrogen atom contained in the ring structure of a purine, 8-azapurine, or benzimidazol residue, and; A is an oxygencontaining moiety, either consisting of an oxygen atom being double bonded, as indicated by the broken line, or a benzoyloxy group, with the proviso that when A is a benzoyloxy group, then R1 is hydrogen.