Patent ID: 8618124

Claim:
A compound of the formula: wherein: X 1 -X 6 are independently O, S or NR 1 ; R 44 and R 44â€² are independently selected polyalkylene oxides; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, aralkyls, and C 3-8 substituted cycloalkyls; R 40-43 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; y and yâ€² are independently zero or a positive integer; p and pâ€² are independently zero or one n and nâ€² are independently a positive integer; a and b are independently zero or a positive integer, provided that a+b is greater than or equal to 2; z is a positive integer; D 10 and D 11 are independently selected from the group consisting of OH, halogens, drugs, enzymes, proteins, therapeutically active compounds, dyes, chelating agents', isotope labeled compounds; Y 7-9 are independently selected from the group consisting of O, S NR 1â€³ ; R 1â€³ is hydrogen or methyl; R 9-18 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; L 3-4 are independently selected bifunctional linkers; Q is selected from the group consisting of -L 5 -C(â•Y 10 )â€” wherein L 5 is the same group that defines L 3-4 and Y 10 is the same group that defines Y 7-9 , hydrophobic moieties, bifunctional linking moieties and combinations thereof; l, k, m and o are independently positive integers; j and h are independently zero or a positive integer; g, i and q are independently zero or one; and Bâ€² is selected from the group consisting of leaving groups, activating groups, OH, biologically active moieties and diagnostic agents.