Patent ID: 7915286

Claim:
Compounds having the structure of Formula I: and their pharmaceutically acceptable salts, stereoisomers, tautomers, racemates, regioisomers or N-oxides, wherein ring P including X 1 , X 2 and X 3 is a six-membered ring containing 1-3 double bonds wherein X 1 and X 2 are carbon and X 3 is nitrogen; ring M (including X 1 , X 2 , X 4 and X 5 ) is a five-membered ring containing 1-2 double bonds, wherein X 1 and X 2 are carbon and X 4 and X 5 are nitrogen; R 1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, aralkenyl, (cycloalkyl) alkyl, heterocyclyl, heteroaryl, (heterocyclyl) alkyl or (heteroaryl) alkyl; R 2 is hydrogen, alkyl, halogen, cyano, nitro, —SR, NRR, —(CH 2 ) n OR {wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl and n is an integer from 0-2}, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, aryl, aralkyl, aralkenyl, heterocyclyl, heteroaryl, (heterocyclyl) alkyl or (heteroaryl) alkyl; R 3 is —NR 5 R 6 {wherein R 5 and R 6 independently are hydrogen, alkyl, alkenyl, alkynyl, acyl, cycloalkyl, aryl, aralkenyl, aralkyl, (cycloalkyl) alkyl, heterocyclyl, heteroaryl, (heterocyclyl) alkyl or (heteroaryl) alkyl}; and R 4 is a radical of Formula I a or I b wherein R 7 and R 8 independently are alkyl, —CN, —(CH 2 ) n C(═O)NR f R q {wherein n is an integer from 0-2 and R f and R q independently are hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl, (heterocyclyl)alkyl, or (heteroaryl)alkyl}, —(CH 2 ) n C(═O)OR f {wherein n and R f are the same as defined earlier}, or —(CH 2 ) n OR f {wherein n and R f are the same as defined earlier}.