Patent ID: 8048890

Claim:
A substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compound corresponding to formula I wherein R 1 and R 2 independently of one another represent H, C 1-8 -alkyl, C 3-8 -cycloalkyl, (C 1-4 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-4 -alkyl)-aryl, heterocyclyl, (C 1-4 -alkyl)-heterocyclyl or NH—C(═O)-aryl, wherein at least one of the radicals R 1 and R 2 does not represent H, or together represent —(CR 4 R 5 ) m —(CR 6 R 7 ) n —Y—(CR 8 R 9 ) p —(CR 10 R 11 ) q — where m=1, n=0 or 1, p=1 or 2 and q=1 or 2, or —CH 2 —CH 2 —C(-aryl)═CH—CH 2 —; R 3 represents COR 13 ; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 independently of one another represent H, C 1-8 -alkyl, or C(═O)R 14 ; Y represents CR 15 R 16 , or NR 17 ; R 13 represents C 1-6 -alkyl, C 3-10 -cycloalkyl, aryl, (C 1-4 -alkyl)-aryl, or heterocyclyl, R 14 represents OR 20 ; R 15 and R 16 independently of one another represent H, aryl, or (C 1-4 -alkyl)-aryl; R 17 represents H, C 3-8 -cycloalkyl, aryl, (C 1-4 -alkyl)-aryl, heterocyclyl or C(═O)R 22 ; R 20 represents C 1-6 -alkyl, R 22 represents aryl, (C 1-4 -alkyl)-aryl, heterocyclyl, or OR 24 ; and R 24 represents C 1-6 -alkyl, or (C 1-4 -alkyl)aryl, or a salt thereof with a physiologically tolerated acid.