Patent ID: 7692016

Claim:
A process for the synthesis of quinoline derivatives wherein R═H, OH, alkyl, aryl, alkyloxy, halo or nitro group which comprises stirring the solution of aniline or substituted aniline in acetic acid, in the presence of a catalyst ‘silferc’ with a molar ratio of substituted aniline to catalyst in the range of 1:1 to 1:3, under inert atmosphere, for a period of 3-6 minutes, adding methyl vinyl ketone slowly to the above reaction mixture over a period of 10-30 minutes, followed by heating to a temperature in the range of 50-90° C., for about 1 hr, further adding a second catalyst ‘anhydrous zinc chloride’ to the above said reaction mixture and refluxing it for a period of 2-5 hrs, cooling, filtering and basifying the above resultant reaction mixture with 5-10% NaOH solution, followed by extraction with ethyl acetate, drying and evaporating the resultant extract to obtain the quinoline derivative in pure form.