Patent ID: 7786173

Claim:
A compound of Formula I: wherein X 1 , Y 1 and Z 1 are independently O, CR a , CR a R b , N, NR c , or S; R 1 and R 2 are independently hydrogen, halo, halo(C 1 -C 10 )alkyl, cyano, —NR a R b , (C 1 -C 20 )alkyl, (C 2 -C 20 )alkenyl, (C 2 -C 20 )alkynyl, (C 1 -C 20 )alkoxy, (C 2 -C 26 )alkoxyalkyl, (C 3 -C 12 )cycloalkyl, (C 6 -C 10 )aryl, (C 7 -C 30 )arylalkyl, (C 2 -C 10 )heterocyclic, (C 4 -C 10 )heteroaryl, or (C 4 -C 10 )heteroaryl(C 1 -C 20 )alkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, or heteroaryl groups of R 1 and R 2 independently are optionally perfluorinated or optionally substituted with 1, 2, 3, or 4 groups where the substituent groups are independently hydroxy, halo, cyano, (C 1 -C 10 )alkoxy, C 6 -aryl, (C 7 -C 24 )arylalkyl, oxo (═O), or imino (═NR d ), wherein one or more of the carbon atoms in the R 1 or R 2 alkyl groups can be independently replaced with non-peroxide oxygen, sulfur or NR c ; the alkyl groups of R 3 are optionally substituted with 1, or 2 hydroxy groups; or R 2 can be a group having formula II, III, IV, V, or VI; wherein each R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , and R 14 is independently O, S, C, CR 15 , CR 16 R 17 , C═O, N or NR 18 ; each R 15 , R 16 and R 17 is independently hydrogen, halo, (C 1 -C 10 )alkyl, (C 6 -C 10 )aryl, (C 1 -C 10 )alkyl substituted with halo, hydroxy, (C 1 -C 10 )alkoxy, or cyano; and where R 18 can be hydrogen or (C 1 -C 10 )alkyl; wherein Z 2 is hydrogen, halo, halo(C 1 -C 10 )alkyl, cyano, —NR a R b , (C 1 -C 20 )alkyl, (C 2 -C 20 )alkenyl, (C 2 -C 20 )alkynyl, (C 1 -C 20 )alkoxy, (C 2 -C 26 )alkoxyalkyl, (C 3 -C 12 )cycloalkyl, (C 6 -C 10 )aryl, (C 7 -C 30 )arylalkyl, (C 2 -C 10 )heterocyclic, (C 4 -C 10 )heteroaryl, or (C 4 -C 10 )heteroaryl(C 1 -C 20 )alkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, or heteroaryl groups of Z 2 are optionally perfluorinated or optionally substituted with 1, 2, 3, or 4 groups where the substituent groups are independently hydroxy, halo, cyano, (C 1 -C 10 )alkoxy, C 6- aryl, (C 7 -C 24 )arylalkyl, oxo (═O), or imino (═NR d ), wherein one or more of the carbon atoms in the Z 2 alkyl groups can be independently replaced with non-peroxide oxygen, sulfur or NR c ; indicates one or more optional double bonds; wherein Y 2 is a bond, O, S, C═O, or NR c , CH 2 ; W 1 is a bond, —CH 2 — and m is 1, 2, or 3, or W 1 is (C═O)(CH 2 ) 1-5 and m is 1; wherein W 1 is optionally interrupted with non-peroxide O, S, C═O, or NR c ; n is 0, 1, 2, or 3; one represents an optional double bond; R 3 is hydrogen, (C 1 -C 10 )alkyl, hydroxy(C 1 -C 10 )alkyl or (C 1 -C 10 )alkoxy; and R 4 is hydroxyl (—OH), phosphate (—OPO 3 H 2 ), phosphonate (—CH 2 PO 3 H 2 ), or alpha-substituted phosphonate; each R a , R b , R c , and R d is independently hydrogen, CF 3 or (C 1 -C 10 )alkyl; or a pharmaceutically acceptable salt or ester thereof.