Patent ID: 6852336

Claim:
A direct compressed solid pharmaceutical dosage form, comprising: a) from about 60 to about 95% by weight acetaminophen in granular form; b) from about 1 to about 40% by weight of a direct compression vehicle comprising microcrystalline cellulose wherein said microcrystalline cellulose has been coprocessed with from about 0.1 to about 20% by weight silicon dioxide, whereby said microcrystalline cellulose and said silicon dioxide are in intimate association with each other; c) from about 0.1 to about 4% by weight of a pharmaceutically acceptable lubricant; said acetaminophen and said direct compression vehicle being combined under shear conditions sufficient to transform said acetaminophen and said direct compression vehicle into a homogeneous granulate without degradation, and which has been directly compressed into a solid pharmaceutical dosage form, said dosage form providing controlled release; d) from about 0.1 to about 5% by weight of a further amount of silicon dioxide.