Patent ID: 7319149

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: E 1 is C(O); E 2 is a direct bond; Hz is the free hydrazine moiety or a hydrazone of the formula —N(R 1 )N═C(R 2 )(R 3 ); R 1 is selected from: H, C 1 -C 10 alkyl substituted with 0-5 R 4, C 2 -C 10 alkenyl substituted with 0-5 R 4 , C 6 -C 10 aryl substituted with 0-3 R 4 , and C 4 -C 10 heteroaryl substituted with 0-3 R 4 ; R 2 and R 3 are independently selected at each occurrence from: H, CN, Co 2 R 5, C(O)R 5, C(O)N(R 5 ) 2 , C 1 -C 10 alkyl substituted with 0-5 R 5, C 2 -C 10 alkenyl substituted with 0-5 R 5, C 3 -C 10 cycloalkyl substituted with 0-5 R 5 , C 6 -C 10 aryl substituted with 0-3 R 5 , and C 4 -C 10 heteroaryl substituted with 0-3 R 5 : or alternatively R 2 and R 3 may be taken together to form a C 3 -C 10 cycloalkyl or C 5 -C 10 cycloalkenyl; R 4 is independently selected at each occurrence from: OH, COOH, C(O)NH 2 , SO 3 H, and SO 2 NH 2 ; R 5 is independently selected at each occurrence from: C(═O)OR 6, C(O)NHR 6, C(═O)R 6 , NHR 6 , NHC(═O)R 6 , NHC(═O)NHR 6 , NHC(═S)NHR 6 , OR 6 , OC(═O)R 6 , OC(═O)OR 6 , PO(OR 6 ), SR 6 , SOR 6 , SO 2 R 6 , SO 3 R 6 , and SO 2 NHR 6 ; R 6 is independently selected at each occurrence from: H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl, and C 4 -C 10 heteroaryl; A 1 is pyridinyl; A 2 is an imine-N-containing C 5 heterocycle substituted with C-2 R 7 ; R 7 is independently selected at each occurrence from: C(═O)CR 8, C(O)NHR 8, C(═O)R 8 , NHR 8 , NHC(═O)R 8 , NHC(═O)NHR 8 , NHC(═S)NHR 8 , OR 8 , OC(═O)R 8 , OC(═O)OR 8 , PO(OR 8 ) 2 , SR 8 , SO 2 R 8 , SO 3 R 8 , and SO 2 NHR 8 ; R 8 is independently selected at each occurrence from: H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl, and C 4 -C 10 heteroaryl; D is selected from the group consisting of O, S and N; and Z is a bond.