Patent ID: 8165651

Claim:
An analyte sensor for use in connection with a biofluid, comprising: a transducer sufficient for generating a signal that corresponds to a concentration of an analyte in a derivative portion of the biofluid when the derivative portion of the biofluid contacts the transducer, wherein the transducer comprises an analyte responsive enzyme and wherein the analyte responsive enzyme oxidizes the analyte; an interface sufficient for passage of the derivative portion of the biofluid toward the transducer when the biofluid contacts the interface; and an organic-metal catalytic agent disposed only in the interface and sufficient to catalyze the degradation of reactive oxygen species and/or reactive nitrogen species of biological origin in the biofluid and/or the derivative portion of the biofluid, the agent selected from a proteinaceous catalytic agent, a non-proteinaceous catalytic agent, or any combination thereof.