Patent ID: 7250444

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt, ester, amide, stereoisomer or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug, wherein: R 2 is benzyl, naphthyl or cyclohexyl, optionally substituted; or phenyl optionally substituted with fluorine, chlorine, bromine, hydroxyl or trifluoromethyl; pyridinyl or pyridinyl substituted with fluorine, chlorine, bromine, hydroxyl or trifluoromethyl; or alkyl of from one to seven carbon atoms; One of R 3 and R 4 is H; aryl, aralkyl, optionally substituted; C 1 -C 8 alkyl straight chain or branched; or C 3 -C 8 cycloalkyl; and the other one of R 3 and R 4 is I, COOR′, R 6 R 7 NC(O)— or SO 2 NR 9 R 10 ; One of R 6 and R 7 is SO 2 NHR 8 or SO 2 R 8 ; and the other one of R 6 and R 7 is H or C 1 -C 4 alkyl; R 8 is aryl, optionally substituted; R 9 and R 10 are each independently H; aryl, aralkyl, optionally substituted with halogen, OR′, (CH 2 ) n COOR′, (CH 2 ) n CONR′R″, (CH 2 ) n SO 2 NR′R″, (CH 2 ) n SO 2 R′ or CN; C 1 -C 10 alkyl unsubstituted or substituted with OH, CO 2 R′ or CONR′R″; R 5 is alkyl of from one to four carbon atoms, optionally substituted with a halogen; R′ and R″ are each independently H, lower alkyl or taken together form a 4-7 member ring; and n is 0-2, with a proviso when R 2 is phenyl substituted with fluorine, R 5 is alkyl, R 4 is aryl and R 3 is COOR′, then R′ is not H or lower alkyl.