Patent ID: 8530457

Claim:
A method for the treatment of lymphangioleiomyomatosis (LAM) comprising administering to a patient in need of said treatment a therapeutically effective amount of a compound having the formula: wherein: R 1 is hydrogen, hydroxy, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, halo, trifluoromethyl, or CN; R 2 is hydrogen; R 3 , R 4 , and R 5 independently are hydrogen, hydroxy, halo, trifluoromethyl, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, nitro, CN, or (O or NH) m —(CH 2 ) n —R 9 , where R 9 is hydrogen, hydroxy, CO 2 H or NR 10 R 11 ; n is 0 to 4; m is 0 or 1; R 10 or R 11 independently are hydrogen or C 1 -C 8 alkyl, or taken together with the nitrogen to which they are attached can complete a 3- to 10-member cyclic ring optionally containing one, two, or three additional heteroatoms selected from O, S, NH, or N—C 1 -C 8 alkyl; R 6 is hydrogen, C 1 -C 8 alkyl, aryl, aralkyl, or C 3 -C 10 cycloalkyl; R 7 is hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 10 cycloalkyl (or cycloalkyl optionally containing a heteroatom selected from O, S, or NR 9 ); X is bromine or iodine; and wherein any of the foregoing alkyl, alkenyl, and alkynyl groups can be unsubstituted or substituted by cycloalkyl (or cycloalkyl optionally containing a heteroatom selected from O, S, or NR 9 ), aryl, aryloxy, heteroaryl, or heteroaryloxy; or R 6 and R 7 taken together with the N—O to which they are attached can complete a 5- to 10-membered cyclic ring, optionally containing one, two, or three additional heteroatoms selected from O, S, or NR 10 R 11 .