Patent ID: 8026263

Claim:
A method for deterring, inhibiting or reversing stenosis, restenosis or unwanted proliferation of an artery in a human or veterinary patient, said method comprising the step of: administering to the patient a compound having the structural formula Wherein, X, Y and Z are same or different and are independently selected from CH2, O, S, NR 1 , N═CH, CH═N and R 2 —C═C—R 3 , where R 2 and R 3 are H or may combine to form a saturated or unsaturated carbocyclic or heterocyclic ring, optionally substituted with one or more R groups; R 1 is selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, acyl and aroyl, optionally substituted with hydroxy, amino, substituted amino, cyano, alkoxy, halogen, trihaloalkyl, nitro, thio, alkylthio, carboxy and alkoxycarbonyl groups; R is selected from H, halogen, trihaloalkyl, hydroxy, acyloxy, alkoxy, alkenyloxy, thio, alkylthio, nitro, cyano, ureido, acyl, carboxy, alkoxycarbonyl, N—(R 4 )(R 5 ) and saturated or unsaturated, chiral or achiral, cyclic or acyclic, straight or branched hydrocarbyl group with from 1 to 20 carbon atoms, optionally substituted with hydroxy, halogen, trihaloalkyl, alkylthio, alkoxy, carboxy, alkoxycarbonyl, oxoalkyl, cyano and N—(R 4 )(R 5 ) group, R 4 and R 5 are selected from H, alkyl, alkenyl, alkynyl, cycloalkyl and acyl or R 4 and R 5 may combine to form a ring, wherein a carbon may be optionally substituted by a heteroatom selected from O, S or N—R 6 , R 6 is H, alkyl, alkenyl, alkynyl, cycloalkyl, hydroxyalkyl or carboxyalkyl, n is 1-5; m is 1 or 2; with the proviso that when m is 1, Q is selected from OH, CN, carboxyalkyl, N—(R 7 )(R 8 ), where R 7 and R 8 are selected from H, lower alkyl (1-4C), cycloalkyl, aryl, acyl, amido, or R 7 and R 8 may combine to form a saturated or unsaturated heterocylic ring and optionally substituted with up to 3 additional heteroatoms selected from N, O, and S; or —NH-heterocycle, where the heterocycle is represented by thiazole, oxazole, isoxazole, pyridine, pyrimidine, and purine and where U and V are selected from H and O; and when m is 2, Q is a spacer of from 2-10 carbons as a straight or branched, chiral or achiral, cyclic or acyclic, saturated or unsaturated, hydrocarbon group, such as phenyl; In the most preferred embodiment of this invention, X, Y, and Z are R 2 —C═C—R 3 , where R 2 and R 3 are H; R is selected from H and halogen, preferably, F and Cl; m is 1; and Q is —N—(R 7 )(R 8 ), where R 7 and R 8 are selected from H, acyl, amido, and R 7 and R 8 combine to form a saturated or unsaturated heterocyclic ring, optionally substituted with up to three heteroatoms selected from N, O, or S, for example, pyrrolidine, piperidine, pyrazole, imidazole, oxazole, isoxazole, tetrazole, azepine, etc., which may be optionally substituted with a lower alkyl or amino group; wherein the compound is administered at a dose that effectively deters, inhibits or reverses stenosis, restenosis or unwanted proliferation of an artery but does not inhibit hepatic cytochrome P450 enzyme activity.