Patent ID: 7893099

Claim:
A compound of formula (I) wherein A 1 is selected from the group consisting of oxygen, carbonyl, —CH 2 O—, —CH 2 —, and —CONR 11 — or is absent; R 1 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, phenyl, halophenyl, alkoxybenzyl, carboxy, morpholinyl, alkylmorpholinyl, dioxothiomorpholinyl, 2-oxo-6-aza-spiro[3.3]heptanyl, piperidinyl, alkylpiperidinyl, hydroxypiperidinyl, halophenylpiperidinyl, piperazinyl, alkylpiperazinyl, azetidinyl, haloazetidinyl, hydroxyazetidinyl, alkoxyazetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]octanyl, hydroxypiridazinyl, halopyrrolidinyl, formyl, pyridinyl, halopyridinyl, tetrahydropyranyl and thiopyranyl; R 2 is hydrogen; R 3 and R 4 are each independently selected from the group consisting of hydrogen, alkyl and phenyl; or R 3 and R 4 together with the carbon atom to which they are attached form cycloalkyl, alkylpiperidinyl or alkoxycarbonylpiperidinyl; or R 2 and R 3 together with the nitrogen atom and carbon atom to which they are attached form pyrrolidinyl; R 5 is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, phenyl, substituted phenyl, benzyl, naphtyl, alkylpyridazinyl, pyridinyl, and halopyridinyl, wherein substituted phenyl is phenyl substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, alkoxyalkoxy, halogen, haloalkyl, haloalkoxy, phenyl, halophenyl, halophenyloxy, alkylsulfonylphenyl, aminosulfonylphenyl, pyridinyl, alkylpyridinyl, halopyridinyl, alkoxypyridinyl, haloalkylpyridinyl, alkylsulfonylpyridinyl, alkylthiazolyl, piperidinyl, halopiperidinyl, hydroxypiperidinyl, 1H-pyrazolyl, alkyl-1H-pyrazolyl, alkyl-2H-pyrazolyl, hydroxyalkyl-1H-pyrazolyl, alkoxyalkyl-1H-pyrazolyl, alkoxycarbonylpyrazolyl, carboxyalkylpyrazolyl, aminocarbonylalkyl-1H-pyrazolyl, alkylaminocarbonylalkylpyrazolyl, oxetanylalkyl-1H-pyrazolyl, pyrimidinyl, alkylthiophenyl, pyridazinyl, alkyl-6-oxo-6H-pyridazinyl, alkylisoxazolyl, cycloalkylpiperazinyl, pyrazinyl, halopyrazinyl, haloazetidinyl, 2-oxo-6-aza-spiro[3.3]heptanyl, halopyrrolidinyl, alkylpiperazinyl, cycloalkylpiperazinyl, haloalkylpiperazinyl, carbonylpiperazinyl, alkylcarbonylpiperazinyl, oxetanyloxy and morpholinyl; and R 11 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.