Patent ID: 8263133

Claim:
A clustered ligand vehicle for delivery of a therapeutic agent to a target expressing a receptor, said vehicle comprising: one or more nanoparticles, each nanoparticle bearing a plurality of ligands, wherein said plurality of ligands comprises a combination of CAP peptides, wherein said CAP peptide are peptides that comprise the amino acid sequence Cys-Cys-Val-Val-Val-Thr (Seq ID NO:1): and CAP-RGD peptides, wherein said CAP-RGD peptides are peptides that comprise the amino acid sequence Cys-Cys-Val-Val-Val-Thr-Arg-Gly-Asp (SEQ ID NO:2); and a carrier comprising said therapeutic agent, wherein each of the one or more nanoparticles is conjugated to the surface of the carrier.