Patent ID: 8741861

Claim:
A method of treating an individual suffering from the vascular-related disease pulmonary arterial hypertension comprising the steps of: a) obtaining a biopsy sample from the individual's pulmonary artery; b) analyzing gene expression levels of the biopsy sample from the pulmonary artery of the individual and the non-diseased control, wherein the analyzing of gene expression levels are for genes unassociated with the vascular-related disease, and further wherein the gene for which expression is analyzed is chosen from the group consisting of HSPE, YES1, CFTR, MAOA, MAOB, and CACNA2D1; c) comparing the gene expression levels between the biopsy sample from the pulmonary artery of the individual and the non-diseased control; d) identifying at least one gene from step c) that is upregulated or downregulated in the biopsy sample based on the non-diseased control; e) obtaining gene products from the genes identified in step c); and f) selecting pharmaceutical agents which are known inhibitors of the gene products from the at least one upregulated gene or known promoters of the gene products from the at least one downregulated gene, wherein the pharmaceutical agents selected are administered to the individual suffering from the vascular-related disease.