Patent ID: 8802657

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Cy 1 is an optionally substituted 5-6 membered partially unsaturated or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; Cy 2 is an optionally substituted 5-14 membered saturated, partially unsaturated, or aromatic monocyclic, bicyclic, or tricyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, and sulfur; L 1 is a direct bond or an optionally substituted, straight or branched C 1-6 alkylene chain; L 2 is a direct bond, or is an optionally substituted, straight or branched C 1-6 alkylene chain wherein 1 or 2 methylene units of L 2 are optionally and independently replaced by —O—, —S—, —N(R)—, —C(O)—, —C(O)N(R)—, —N(R)C(O)N(R)—, —N(R)C(O)—, —N(R)C(O)O—, —OC(O)N(R)—, —SO 2 —, —SO 2 N(R)—, —N(R)SO 2 —, —OC(O)—, —C(O)O—, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C 1-6 aliphatic group; R 1 is hydrogen or an optionally substituted C 1-6 aliphatic group; each of R x and R y is independently selected from —R 2 , -halo, —NO 2 , —CN, —OR 2 , —SR 2 , —N(R 2 ) 2 , —C(O)R 2 , —CO 2 R 2 , —C(O)C(O)R 2 , —C(O)CH 2 C(O)R 2 , —S(O)R 2 , —S(O) 2 R 2 , —SO 2 N(R 2 ) 2 , —OC(O)R 2 , —N(R 2 )C(O)R 2 , —N(R 2 )N(R 2 ) 2 , —N(R 2 )—C(═NR 2 )N(R 2 ) 2 , —C(═NR 2 )N(R 2 ) 2 , —C═NOR 2 , —N(R 2 )C(O)N(R 2 ) 2 , —N(R 2 )SO 2 N(R 2 ) 2 , —N(R 2 )SO 2 R 2 , and —OC(O)N(R 2 ) 2 ; and each R 2 is independently hydrogen or an optionally substituted group selected from C 1-6 aliphatic, a C 6-10 monocyclic or bicyclic aryl ring, and a 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or two R 2 on the same nitrogen are taken together with the nitrogen to form an optionally substituted 5-8 membered saturated, partially unsaturated, or aromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur.