Patent ID: 7834009

Claim:
A compound of Formula I wherein R 1 , R 2 , R 3 , and R 4 are independently H, halo, cyano, hydroxyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, amino, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkylene(cycloalkyl), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, C 1 -C 6 alkylene(aryl), heterocyclyl, or C 1 -C 6 alkylene(heterocyclyl) or R 1 and R 2 or R 3 and R 4 can combine with the atom(s) to which they are attached to form a 3- to 6-membered spiro cycloalkyl ring or R 3 and R 5 or R 4 and R 5 can combine with the atom(s) to which they are attached to form a 4- to 6-membered heterocyclyl ring, R 5 is H, amino, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkylene(cycloalkyl), C 1 -C 6 alkylene(aryl), C 1 -C 6 alkylene(heterocyclyl), aryl, or heterocyclyl, R 6 is wherein n is 2, X is N, and Ring A is a 5- or 6-membered aryl, optionally substituted by 1-3 R 8 moieties, R 8 is H, halo, nitro, —CHR 9 S(O) 2 R 10 , —NR 10 R 11 , —NR 9 S(O) 2 R 10 S or NR 9 S(O) 2 NR 10 R 11 , wherein R 9 , R 10 , and R 11 are independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, aryl, or heterocyclyl, or R 9 and R 10 or R 10 and R 11 combine with the atom(s) to which they are attached to form a 5- or 6-membered heterocyclyl ring, wherein the above alkyl, alkenyl, alkynyl, aryl, cycloalkyl, or heterocyclyl moieties provided in R 1 , R 2 , R 3 , R 4 , R 5 , R 9 , R 10 , and R 11 are each optionally and independently substituted by 1-3 substituents selected from alkoxy, alkylamine, amino, aryl, cycloalkyl, heterocyclyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms, carboxyl, cyano, halo, hydroxy, nitro, oxo, —C(O)OH, —C(O) 2 (C 1 -C 6 alkyl), —C(O) 2 (C 3 -C 8 cycloalkyl), —C(O) 2 (aryl), —C(O) 2 (heterocyclyl), —C(O) 2 (C 1 -C 6 alkylene)aryl, —C(O) 2 (C 1 -C 6 alkylene)heterocyclyl, —C(O) 2 (C 1 -C 6 alkylene)cycloalkyl, —C(O)(C 1 -C 6 alkyl), —C(O)(C 3 -C 8 cycloalkyl), —C(O)(aryl), —C(O)(heterocyclyl), —C(O)(C 1 -C 6 alkylene)aryl, —C(O)(C 1 -C 6 alkylene)heterocyclyl, and —C(O)(C 1 -C 6 alkylene)cycloalkyl, wherein each of the above optional substituents can be further optionally substituted by 1-5 substituents selected from amino, cyano, halo, hydroxy, nitro, C 1 -C 6 alkylamine, C 1 -C 6 dialkylamine, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkenyl, and C 1 -C 6 hydroxyalkyl, wherein each alkyl is optionally substituted by one or more halo substituents, or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.