Patent ID: 7560479

Claim:
Compounds having the structure of Formula I: and their pharmaceutically acceptable salts, pharmaceutically acceptable enantiomers, diastereomers, or N-oxides, wherein Ar represents an aryl or a heteroaryl ring having 1-2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhaloalkyl (C 1 -C 4 ), cyano, hydroxy, nitro, halogen (e.g. F, Cl, Br, I), lower alkoxy (C 1 -C 4 ), lower perhalo-alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ) or N-lower alkylamino carbonyl (C 1 -C 4 ); R 1 represents a hydrogen, hydroxy, hydroxymethyl, amino, alkoxy , carbamoyl or halogen (e.g. fluorine, chlorine, bromine and iodine); R 2 represents alkyl, C 3 -C 7 cycloalkyl ring in which any 1-4 hydrogen atoms are substituted with halogen (e.g. F, Cl, Br, I), carbamoyl or lower alkyl; W represents (CH 2 ) p , where p represents 0 to 1; X represents an oxygen, sulphur, NR or no atom wherein R represents hydrogen or C 1 -C 6 alkyl; Y represents CHR 5 CO wherein R 5 represents hydrogen, methyl or (CH 2 )q wherein q represents 0 to 4; R 3 represents hydrogen, lower alkyl or CO 2 C(CH 3 ) 3 ; R 6 and R 7 are independently selected from H, lower alkyl, COOH, CONH 2 , NH 2 , CH 2 NH 2 ; and R 4 represents C 1 -C 15 saturated or unsaturated aliphatic hydrocarbon (straight chain or branched) in which any 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen, arylalkyl, arylalkenyl, heteroarylalkyl or heteroarylalkenyl having 1 to 2 hetero atoms selected from the group consisting of nitrogen, oxygen and sulphur atoms with an option that any 1 to 3 hydrogen atoms on an aryl or heteroaryl ring in said arylalkyl, arylalkenyl, heteroarylalkenyl group may be substituted with lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhaloalkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ), or N-lower alkylamino carbonyl (C 1 -C 4 ).