Patent ID: 7141570

Claim:
A compound of formula I or pharmaceutically acceptable salts thereof wherein: A is a structure i, ii, iii, or iv; W is —N(H)C(X)—R 1 , Het, or —Y-HET, in which the Het or —Y-HET is optionally substituted with ═S or ═O, provided that when A is structure iv, W is not —Y-HET or Het; X is O or S; Y is NH, O, or S; Z is R 1 is a) H, b) NH 2 , c) NHC 1-4 alkyl, d) C 1-4 alkyl, e) C 2-4 alkenyl, f) O—C 1-4 alkyl, i) S-C 1-4 alkyl, or j) (CH 2 ) s C 3-6 cycloalkyl, in which each occurrence of alkyl or cycloalkyl in R 1 is optionally substituted by one, two or three halogens (F or Cl); each R 2 and R 3 is independently hydrogen, halogen (F or Cl), methyl or ethyl; R 4 is H, CH 3 or F; R 5 is H or C 1-4 alkyl; R 6 is H, C 1-4 alkyl, or or R 5 and R 6 together form an optionally substituted saturated heterocycle; R 7 is H, or C 1-4 alkyl which can be optionally substituted by —OH, —NH 2 , —NH—C(═NH)—NH 2 , —SH, —SCH 3 , —COOH, —C(O)NH 2 , phenyl which can be optionally substituted with —OH; R 8 is H or CH 3 ; R 9 is H, CH 3 , —C(O)—CH(R 7 )—NR 8 R 8 , R 10 or R 11 is halo, C 1-4 alkyl, CF 3 , —CN, —NO 2 , —OH, —O—C 1-4 alkyl, —NH—S(O) w C 1-4 alkyl; R 12 is H, C 1-4 alkyl, —S(O) 2 —C 1-4 alkyl, or R 5 and R 12 together form a saturated heterocycle; R 13 is H, or R 14 is —(CH 2 ) t NHR 13 , —OH, —OC 1-4 alkyl; m is 0, 1, 2, 3, 4; n is 0, 1, 2, 3, 4 with the proviso that m plus n is 2, 3, 4, or 5; p is 2, 3; q is 1, 2; r, s and t are independently 0, 1; u and w are independently 0, 1, 2; and provided that W is not Het or —Y-HET when Z is a, b, or d, and further provided that Z is not b when A is formula iii.