Patent ID: 7192593

Claim:
An infectious chimeric parainfluenza virus (PIV) comprising a major nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large polymerase protein (L), and a partial or complete PIV genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) encoding a complete open reading frame or one or more antigenic determinant(s) of one or more heterologous pathogen(s) operably linked to regulatory sequences operable in said PIV genome or antigenome to form a chimeric PIV genome or antigenome; said partial or complete PIV genome or antigenome comprising a polynucleotide encoding a wild-type L protein of the PIV; said infectious chimeric PIV being attenuated for replication at least 10-fold in the respiratory tract of a primate host infected with said chimeric PIV compared to the corresponding wild-type PIV.