Patent ID: 8252804

Claim:
A compound of Formula I: wherein R 1 is one of (a) a hydrogen (H)), (b) an OH, (c) a CH 3 , and (d) NHR wherein R is either a H or an alkyl group having from 1 to 6 carbon atoms, and tautomers of said (b) and said (d); R 2 is one of (a) a hydrogen (H), (b) a CH 3 , (c) an OH, and (d) NHR wherein R is either a H or an alkyl group having from 1 to 6 carbon atoms; A is NR′, wherein R′ is either a H or an alkyl group having from 1 to 6 carbon atoms; wherein the bond at position 5-6 may either be a single or a double bond; wherein the five membered ring has a side chain attached at positions 5, 6 or 7, and optionally includes wherein the carbon atoms at positions 5 and 6, independently, have attached thereto either (a) two hydrogen atoms if the bond between carbon atoms 5 and 6 is a single bond or one hydrogen atom if the bond between carbon atoms 5 and 6 is a double bond, or (b) an alkyl group having from one to six carbon atoms and a hydrogen atom if the bond between carbon atoms at positions 5 and 6 is a single bond or an alkyl group having from one to six carbon atoms if the bond between carbon atoms 5 and 6 is a double bond, and combinations thereof, and R 3 is one of (a) a hydrogen (H), (b) CH 3 , (c) trifluoromethyl, (d) difluoromethyl, (e) monofluoromethyl, (f) methyl ketone, (g) trifluoromethyl ketone, (h) difluoromethyl ketone, (i) monofluoromethyl ketone, (j) formyl, (k) methyl alcohol, (l) methylamine, or (m) a bond; X is either a heterocycloalkyl-carbonyl-L-glutamate group, a heterocycloaryl-carbonyl-L -glutamate group, or a hydrogen (H), and wherein X is a hydrogen then R 4 is a heterocycloalkyl -carbonyl-L-glutamate group or a heterocycloaryl-carbonyl-L-glutamate group, and wherein X is a heterocycloalkyl-carbonyl-L-glutamate group or a heterocycloaryl-carbonyl-L-glutamate group then R 4 is a hydrogen or a bond; wherein R 5 is the same as R 3 except that R 5 is not a bond; y is an integer ranging from zero up to and including 6; z is an integer ranging from zero up to and including seven, wherein the sum total of integers y and z is equal to or less than seven when the side chain attachment is at position 5, and wherein when the side chain attachment is at position 6 or 7 then (i) the sum total of integers y and z is five, six, or seven when X=H, (ii) the sum total of integers y and z is equal to zero when R 5 is H, (iii) y is equal to five or six and z is equal to zero when R 5 is H and X is not H, or (iv) z is equal to five, six, or seven and y is equal to zero when X is H and R 5 is not H; and wherein said side chain of Formula I has one or more double bonds consisting of E-isomers and Z-isomers, wherein the double bonds are formed when R 3 and/or R 4 are bonds.