Patent ID: 7691628

Claim:
A method of screening for a substance which is useful in the treatment of a lipid metabolism dysfunction associated with apolipoprotein C-III, comprising contacting said substance with a human Rev-erb receptor protein (hRev-erb) or a protein which at least comprises the hRev-erb ligand binding site and the hRev-erb DNA binding site; providing a hRev-erb response element or a polynucleotide sequence onto which said Rev-erb receptor is capable of binding thereto; and detecting the transcriptional activity of a gene which is under the control of a promoter comprising said response element in the presence and absence of said test substance, wherein a decrease of said transcriptional activity of said gene in the presence of said test substance indicates that said test substance is useful in the treatment of said lipid metabolism dysfunction associated with apolipoprotein C-III.