Patent ID: 8546417

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, and —C(O)Y, wherein Y is hydroxy, alkoxy, amino, alkylamino, or dialkylamino; Q 1 is CR 20 R 24 ; Q 2 is CR 21 R 22 ; and Q 3 is N; R 20 , R 21 , R 22 , and R 24 are each independently selected from the group consisting of hydrogen and alkyl; or R 20 and R 21 together form a bond and R 22 and R 24 are independently hydrogen or alkyl; Z is selected from the group consisting of Z 1 , Z 2 , Z 3 , Z 4 , and Z 5 , wherein: Z 1 is Z 2 is —CR 3 R 4 —(CH 2 ) n -D-R 9 ; Z 3 is —SO 2 —R 10 ; Z 4 is and Z 5 is R 3 and R 4 are both hydrogen or together form ═O; R 5 , R 6 , R 7 and R 8 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, cyano, amino, aminoalkyl, alkylamino, and dialkylamino; R 9 is selected from the group consisting of phenyl optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, aminoalkyl, alkylamino, and dialkylamino, or two substituents in adjacent carbon atoms in the phenyl ring optionally form a bridge —O—CH 2 —O—; and pyridyl optionally substituted with one or two substituents independently selected from the group consisting of alkyl, haloalkyl, halogen, haloalkoxy, and alkoxy; or -D-R 9 together forms R 10 is phenyl optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, amino, alkylamino, dialkylamino, and alkylcarbonylamino; or 1,2,3,4-tetrahydroquinolinyl or 1,2,3,4-tetrahydroisoquinolinyl optionally substituted at the nitrogen atom with alkylcarbonyl or haloalkylcarbonyl; R 11 and R 12 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkoxycarbonyl, hydroxyalkyl, haloalkyl, mercaptoalkyl, aminoalkyl; phenyl optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, halogen, and haloalkyl; and benzyl, wherein the phenyl ring is optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy, halogen, and haloalkyl; R 13 is hydrogen and R 14 is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, and aminoalkyl; R 15 is selected from the group consisting of alkylthioalkyl, 2-benzo[b]thienyl, benzo[b]thienyl, 1-benzo[c]thienyl, 3-benzo[c]thienyl, 2-benzofuryl, 3-benzofuryl, 1-isobenzofuryl, 3-isobenzofuryl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl, 1 piperidinyl, and 1-pyrrolidinyl; A is —C(O)—, CH 2 , or is absent, and B is CH or N; or A-B is CH═C (where CH is attached to —(CH 2 ) m —); D is —C(O)— or is absent; m is 0, 1, 2, 3, 4, or 5; n is 0, 1, 2, or 3; and p is 0 or 1.