Patent ID: 7314641

Claim:
A high-bioavailability particle coated with fungicide and polymer, comprising: (a) a coating layer comprising 20˜40 wt. % of itraconazole, 17˜30 wt. % of poloxamer 407 polymer, 2˜10 wt. % of acidic substance, 15˜30 wt. % of talc, 2˜6 wt. % of bonding agent, ethanol and dichloromethane based on the coating layer; (b) an anticoagulant layer comprising 50˜70 wt. % of talc, 25˜35 wt. % of hydroxypropyl methylcellulose (HPMC) and 1˜10 wt. % of plasticizer based on the anticoagulant layer; and (c) a particulate core having a diameter 300˜500 μm(30˜50 mesh).