Patent ID: 7794956

Claim:
A method of identifying modulators of the glucose homeostasis pathway, that act on the Gab1 protein signaling pathway comprising the steps of: (a) obtaining a system comprising a control group and a test group, wherein the control group and the test group comprise one set of cells expressing Gab1 protein and another set of cells not expressing Gab1 protein; (b) exposing the control group to a solution of glucose and the test group to a solution of glucose and one or more candidate compounds, wherein the candidate compound is not insulin; (c) measuring the glucose levels of the control group and the test group; (d) comparing the glucose levels of the control group to the glucose levels of the test group; and (e) identifying whether the one or more candidate compounds are modulators of the Gab1 protein signaling pathway, wherein a difference in the glucose levels between the cells expressing Gab1 protein and the cells not expressing Gab1 protein in the test group indicates that the candidate compound is a modulator of the glucose homeostasis pathway.