Patent ID: 7919076

Claim:
A conjugate comprising monomeric units linked to form a polymeric chain, wherein (a) 60 to 99% of the monomeric units are N-(2-hydroxypropyl)methacrylamide; (b) 1 to 25% of the monomeric units are methacryloylated hydrazones formed from an aliphatic keto group of an anthracycline cancerostatic and a methacryloylated hydrazide, wherein each methacryloylated hydrazide is independently selected from the group consisting of: C-hydrazides of N-methacryloyl-α-amino acids, C-hydrazides of N-methacryloyl-ε-amino acids, C-hydrazides of N-methacryloyl aromatic amino acids, and C-hydrazides of oligopeptides methacryloylated on their terminal amino group; and (c) 0.5 to 15% of the monomeric units are independently N-methacryloyl-α-amino acids, N-methacryloyl-ε-amino acids, N-methacryloyl aromatic amino acids, or oligopeptides methacryloylated on their terminal amino group; or sodium salts of any of these.