Patent ID: 7763234

Claim:
A pharmaceutical characterized by general formula (I) Z—L-V (I) wherein V denotes a peptide with a binding sequence -X 1 -X 2 -Val-Tyr-Ile-His-Pro-X 8 -X 9 -X 10 , (SEQ ID NO. 1) L denotes bond or a linker, Z denotes a chelating agent suitable for carrying a radionuclide M, X 1 denotes-NY 1 —(CH 2 ) m —CO— where m is an integer from 1 to 10 and Y 1 is H or an alkyl- or aryl-containing substituent, X 2 denotes Arg, N-alkylated Arg, or Phe[4-guanidino] or Gly-4-piperidyl[N-amidino], X 8 denotes Gly, Phe, Phg, Hph, Bip, Ala, Tyr, His, Trp or Nal, X 9 and X 10 denote, independent of each other, Pro, Arg, His, Ala, Phe, Glu, Leu, Val, Ile, Met, Trp, Asp or Lys and where X 8 , X 9 and X 10 together constitute an ACE cleavage site; and wherein the residues Val and Ile at position 3 and 5 respectively may be replaced with the amino acids cysteine or homocysteine capable of forming a bridging unit wherein the bridge contain a —CH 2 —CH 2 —, —S—CH 2 —, —S—CH 2 —S—, lactam or -—S—S— unit, Z forms a bond with the amino acid X 1 optionally through the linker L, and M is selected from 67 Ga, 111 In, 81m Kr, 99 Mo, 98m Tc, 201 Tl, 68 Ga and 82 Rb.