Patent ID: 7790369

Claim:
A method for synthesizing a nucleic acid polymer, the method comprising: synthesizing in parallel a plurality of different oligomeric nucleic acid building blocks, wherein each of the plurality of different oligomeric nucleic acid building blocks is synthesized in situ bound to a reaction area on a single support, wherein the oligomeric nucleic acid building blocks are partially complementary oligonucleotide building blocks, wherein the plurality of oligomeric building blocks is synthesized on a plurality of reaction areas, wherein the single support comprises multiple channels, wherein each channel comprises one or more reaction spaces for synthesis of oligomeric nucleic acid building blocks and one or more reaction chambers for contacting oligomeric nucleic acid building blocks, wherein each reaction space comprises multiple reaction areas, and wherein each reaction area is on a surface of the channel in the reaction space, detaching the plurality of oligomeric nucleic acid building blocks from the one or more reaction areas on the single support and contacting the detached plurality of oligomeric nucleic acid building blocks with one another in multiple reaction chambers to synthesize the nucleic acid polymer, wherein the contacting comprises forming multiple partial nucleic acid polymers that are subsequently combined to form the nucleic acid polymer.