Patent ID: 6939376

Claim:
An endovascular stent for placement at a vascular injury site, for inhibiting restenosis at the site, comprising a body formed of one or more filaments, carried on the one or more filaments, a bioerodable drug-release coating having a thickness of between 3-20 microns, and composed of (i) 20-60 weight percent poly-dl-lactide polymer substrate and (ii) 40-80 weight percent of macrocyclic triene immunosuppressive compound, and a polymer undercoat having a thickness of between 1-5 microns, disposed between the stent-body filaments and said coating, said stent being expandable from a contracted condition in which the stent can be delivered to a vascular injury site via a catheter, and an expanded condition in which the stent coating can be placed in contact with the vessel at the injury site, said coating being effective to release a restenosis-inhibiting amount of the compound over a period of at least 4 weeks after the stent is placed at the vascular injury site.