Patent ID: 7314953

Claim:
A method of inhibiting sodium ion transport in an airway epithelial cell comprising contacting the cell with a compound including an oxyamide linkage wherein the compound is trichostatin, SAHA, or a compound of formula (I) wherein A is a cyclic moiety selected from the group consisting of C 3-14 cycloalkyl, 3-14 membered heterocycloalkyl, C 4-14 cycloalkenyl, 3-8 membered heterocycloalkenyl, aryl, or heteroaryl; the cyclic moiety being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, hydroxylalkyl, halo, haloalkyl, amino, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, alkylsulfonylamino, aminosulfonyl, or alkylsulfonyl; or A is a saturated branched C 3-12 hydrocarbon chain or an unsaturated branched C 3-12 hydrocarbon chain optionally interrupted by —O—, —S—, —N(R a )—, —C(O)—, —N(R a )—SO 2 —, —SO 2 —N(R a )—, —N(R a )—C(O)—O—, —O—C(O)—N(R a )—, —N(R a )—C(O)—N(R b )—, —O—C(O)—, —C(O)—O—, —O—SO 2 —, —SO 2 —O—, or —O—C(O)—O—, where each of R a and R b , independently, is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxylalkyl, hydroxyl, or haloalkyl; each of the saturated and the unsaturated branched hydrocarbon chain being optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, hydroxylalkyl, halo, haloalkyl, amino, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, alkylsulfonylamino, aminosulfonyl, or alkylsulfonyl; each of Y 1 and Y 2 , independently, is —CH 2 —, —O—, —S—, —N(R c )—, —N(R c )—C(O)—O—, —O—C(O)—N(R c )—, —N(R c )—C(O)—N(R d )—, —O—C(O)—O—, or a bond; each of R c and R d , independently, being hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxylalkyl, hydroxyl, or haloalkyl; L is selected from the group consisting of: a saturated straight C 4-10 hydrocarbon chain substituted with C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, or amino, and further optionally interrupted by —O— or —N(R c )—; an unsaturated straight C 4-8 hydrocarbon chain containing 2-5 double bonds optionally substituted with C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, or C 1-4 alkoxy, and further being optionally interrupted by —O— or —N(R g )—, where R g is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxylalkyl, hydroxyl, or haloalkyl; or —(CH═CH) m — where m is 2 or 3, L being optionally substituted with C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, or C 1-4 alkoxy, and further being optionally interrupted by —O— or —N(R g )—; R 1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxylalkyl, hydroxyl, haloalkyl, or an amino protecting group; and R 2 is hydrogen, alkyl, hydroxylalkyl, haloalkyl, or a hydroxyl protecting group; each of X 1 and X 2 , independently, is —O—: or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit sodium ion transport.