Patent ID: 7211263

Claim:
A method for protecting against the toxic effects of infection by a first Bordetella species in a mammal, comprising: administering to said mammal a preparation comprising purified adenylate cyclase of a second Bordetella species in an amount sufficient to protect against the toxic effects of said first Bordetella species, wherein: (a) said purified adenylate cyclase exhibits a specific activity of greater than or equal to about 115 μmole cAMP/min/mg protein; (b) said purified adenylate cyclase sediments on a sucrose density gradient with a coefficient S equal to 3.6 and has a molecular weight of 43 or 45 kDa; (c) said first Bordetella species is Bordetella pertussis ; and (d) said second Bordetella species is Bordetella bronchiseptica.