Patent ID: 7074932

Claim:
A process of preparing a compound of the formula R 1 â€”CHâ•CHCH 2 OC(O)â€”Xâ€”R 2 (I), wherein R 1 is quinolyl optionally substituted with one or more of: (i) alkyl, (ii) alkoxy, (iii) aryl, (iv) nitro, and (v) halo; R 2 is iso-propyl or t-butyl; X is â€”Oâ€” or â€”NR 3 ; and R 3 is hydrogen, C 1 â€“C 6 -alkyl or aryl; or R 2 and R 3 taken together form an aromatic or non-aromatic ring, comprising the steps of: (a) preparing an intermediate R 1 â€”CHâ•CHC(O)OR 5 , wherein R 5 is C 1 to C 6 alkyl; (b) reducing the intermediate obtained in step (a) with an aluminum hydride reagent selected from the group consisting of lithium aluminum hydride alone or with AlCl 3 , diisobutyl aluminum hydride, and sodium bis(2-methoxyethoxy)aluminum hydride in toluene; and (c) optionally coupling the compound obtained from step (b) with an acylating reagent.