Patent ID: 7186749

Claim:
A compound of Formula 4: or a solvate, hydrate or pharmaceutically acceptable salt or ester form thereof; wherein: Ar is aryl; R 1 is hydrogen, C 1 –C 12 alkyl, C 6-14 aryl, C 6-14 ar(C 1-6 )alkyl, —(CH 2 ) p -heteroaryl, —(CH 2 ) p —CO-aryl, —(CH 2 ) p —CO-heteroaryl, —(CH 2 ) p —CO—(C 1 –C 6 )alkyl, C 2 –C 7 alkenyl, C 2 –C 7 alkynyl, or C 3 –C 8 cycloalkyl, R 2 and R 3 are independently hydrogen, C 1 –C 12 alkyl, C 6-14 aryl, C 6-14 ar(C 1-6 )alkyl, —(CH 2 ) p -heteroaryl, halogen, C 1 –C 6 alkoxy, aralkyl, alkoxyaryl, nitro, carboxy(C 1 –C 6 alkyl), carbamide, carbamate, or C 3 –C 8 cycloalkyl; R 4 is —CH(R 6 )(CH 2 ) n R 5 , —C(CH 3 ) 2 R 6 , —CH(R 5 )(CH 2 ) n R 6 , —CH(R 5 )C 6 H 4 R 6 , —CH(R 5 )C 6 H 3 (CO 2 H) 2 , or CH(R 5 )C 6 H 2 (CO 2 H) 3 ; R 5 is hydrogen, C 1 –C 6 alkyl, C 6 –C 12 aryl, aralkyl, C 3 –C 8 cycloalkyl, or —(CH 2 ) n (R 7 ); R 6 is CO 2 H or tetrazole; R 7 is n is from 0 to 6; and p is from 0 to 3.