Patent ID: 8889704

Claim:
A compound of general Formula I and stereoisomers, pharmaceutically acceptable salts and solvates thereof, wherein: R 1 is H, halogen, CN, OH, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, cyano(1-6C)alkyl, (1-3C alkoxy)(1-6C)alkyl (optionally substituted with hydroxy), di(1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy, fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxy(2-6C)alkoxy, cyano(1-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy, di(1-3C alkoxy)(2-6C)alkoxy, (3-6C cycloalkyl)methoxy, oxetanylmethoxy (optionally substituted with methyl), (1-6C alkyl)sulfanyl, —C(═O)NR a R b , —CH 2 C(═O)NR c R d , or (3-6C)cycloalkyl optionally substituted with —CH 2 OH or —CH 2 O(1-4C alkyl); R a , R b , R c and R d are independently selected from H and (1-4C)alkyl; R 2 is H, halogen, CN, OH, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, (1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy (optionally substituted with (1-6C alkyl)C(═O)O—, amino(1-6C alkyl)C(═O)O—, or phenyl(C═O)O—), fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxy(2-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy, (3-6C cycloalkyl)methoxy, (3-6C)cycloalkoxy (optionally substituted with OH), oxetanylmethoxy (optionally substituted with methyl), tetrahydropyranyloxy, (1-6C alkyl)sulfanyl, hydroxy(2-6C alkyl)sulfanyl, (1-3C alkylsulfanyl)(2-6C)alkoxy, —COOH, hetAr 1 , —C(═O)NR e R f , —NR e C(═O)R f , oxetanyl, or cyclopropyl optionally substituted with —CH 2 OH or —CH 2 O(1-6C alkyl); or R 1 and R 2 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having 1-2 ring heteroatoms independently selected from O and N, wherein said ring is optionally substituted with (1-4C)alkyl; hetAr 1 is a 5-6 membered heteroaryl ring having one or two ring nitrogen atoms and optionally substituted with one or more groups selected from (1-6C)alkyl; R e and R f are independently H, (1-6C)alkyl or cyclopropyl optionally substituted with (1-4C)alkyl; R 3 is H, halogen or (1-6C)alkyl; R 4 is R 5 is CF 3 , CH 2 F, CHF 2 , methyl or ethyl; R 5a is H or methyl; or R 5 and R 5a together with the atom to which they are attached form a cyclopropyl ring; R 6 is H, NH 2 , OH, (1-6C alkyl)NH—, fluoro(1-6C alkyl)NH—, hydroxy(1-6C alkyl)NH—, (3-6C cycloalkyl)CH 2 NH—, (1-6C alkyl)C(═O)NH—, (1-6C alkyl)OC(═O)NH— (optionally substituted with 5-methyl-2-oxo-1,3-dioxol-4-yl) or amino(1-6C)alkyl-; R 7 is H, (1-6C)alkyl, fluoro(1-6C)alkyl or hydroxy(1-6C)alkyl; or R 6 and R 7 together with the atom to which they are attached form a 5-6 membered spirocyclic heterocycle having a ring nitrogen atom; R 8 is H, halogen, OH, or (1-6C)alkoxy, or R 6 and R 8 together with the carbon atoms to which they are attached form a cyclopropyl ring optionally substituted with NH 2 ; R 9 is H, or R 6 and R 9 together form a linking group having the formula —CH 2 NH— which links the carbon atoms to which they are attached; and R 10 is H or halogen.