Patent ID: 8182790

Claim:
A contrast agent of the general formula (I): Z 1 -L-V-Z 2 (I) wherein Z 1 is a SPECT or PET reporter moiety; Z 2 is an optical imaging reporter moiety; L comprises one or more dicarboxylic acid units, ethyleneglycol units or a monodisperse PEG-like structure of 17-amino-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic acid of formula (V) wherein m equals an integer from 1 to 10 and where the C-terminal unit is an amide moiety; and, V is a moiety of formula (VI) R a —C(═O)—X 1 —X 2 —X 3 -G-D-X 4 —X 5 —X 6 (VI) comprising two cyclising bridges, wherein, X 1 represents a covalent bond or 1, 2, 3, 4 or 5 amino acid residues; X 2 and X 4 represent independently amino acids residues that forms a cyclising bridge, X 3 represents arginine, or N-methylarginine; X 5 represents a tyrosine, a phenylalanine, a 3-iodo-tyrosine or a naphthylalanine residue; X 6 represents an amino acid residue that forms a cyclising bridge; R a represents the moieties —(CH 2 ) n — or —(CH 2 ) n —C 6 H 4 — that forms a bridge to either of X 2 , X 4 or X 6 ; and n represents a positive integer from 1 to 10.