Patent ID: 8778924

Claim:
A once-a-day amoxicillin product comprising: an immediate release component that includes amoxicillin and at least one modified release component, wherein the at least one modified release component comprises a first delayed release component that comprises amoxicillin coated with methacrylic acid copolymer dispersion and that initiates release of amoxicillin after the immediate release component, and a second delayed release component that comprises amoxicillin coated with a methacrylic acid copolymer dispersion and hypromellose acetate succinate and that initiates release of amoxicillin after the first delayed release component; said product when administered as a single dose in the fed state having: (a) a ratio of AUC (2-5) to AUC (0-2) of at least 2.0:1 and (b) a ratio of AUC (5-12) to AUC (0-2) of at least 1.1:1, and wherein AUC (2-5) to AUC (0-2) ratio is no greater than 10:1 and the AUC (5-12) to AUC (0-2) ratio is no greater than 10:1 and wherein the product is a once-a-day product.