Patent ID: 7482436

Claim:
A gene fragment coding for a single chain Fv (hereinafter referred to as “scFv”) of a human anti-human IL-6 antibody that binds to human IL-6 with a dissociation constant (K D ) of 1.0×10 −8 M or less, said gene fragment consisting of a gene fragment coding for a VH chain of said human anti-human IL-6 antibody bound to a gene fragment coding for a VL chain of said human anti-human IL-6 antibody; wherein complementarity determining regions (CDR1 to CDR3) of said VH chain have the following amino acid sequences: CDR1: Lys Tyr Tyr Met Ala (SEQ ID NO: 5) CDR2: Thr Ile Ser Asn Ser Gly Asp Ile Ile (SEQ ID NO: 6) Asp Tyr Ala Asp Ser Val Arg Gly CDR3: Glu Tyr Phe Phe Ser Phe Asp Val (SEQ ID NO: 7) and/or complementarity determining regions (CDR1 to CDR3) of said VL chain have the following amino acid sequences: CDR1: Arg Ala Ser Gln Asp Ile Arg Asn (SEQ ID NO: 8) Trp Val Ala CDR2: Asp Gly Ser Ser Leu Gln Ser (SEQ ID NO: 9) CDR3: Gln Gln Ser Asp Ser Thr Pro Ile (SEQ ID NO: 10) Thr Phe.