Patent ID: 8658692

Claim:
A method for preparation of an inclusion-complex comprising a physiologically active hydrophobic substance in cyclodextrin or a derivative thereof, comprising: (a) agitating powdered cyclodextrin or a derivative thereof in an agitator at 800 to 2,000 rpm; (b) spraying a physiologically active hydrophobic substance dissolved in alcohol onto the powdered cyclodextrin or the derivative thereof in the agitator to form the inclusion-complex, wherein the physiologically active hydrophobic substance is sprayed while agitating the powdered cyclodextrin or the derivative thereof in the agitator; and (c) drying and milling the inclusion-complex obtained from the preceding step, wherein the cyclodextrin derivative is selected from a group consisting of a hydroxyalkyl cyclodextrin, a carboxyalkyl cyclodextrin, a branched cyclodextrin, a polymer type cyclodextrin formed by combining two or more cyclodextrins, and mixtures thereof.