Patent ID: 8470342

Claim:
A pharmaceutical composition comprising: a therapeutically effective amount of a D-type oligodeoxynucleotide, wherein the D oligodeoxynucleotide has a sequence: (SEQ ID NO: 21) 5′ X 1 X 2 X 3 Pu 1 Py 2 CpG Pu 3 Py 4 X 4 X 5 X 6 (W) M (G) N -3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10, and wherein the D oligodeoxynucleotide is 18 to 50 nucleotides in length; and a therapeutically effective amount of an agent that increases the expression and/or activity of CXCL16 wherein the agent is a metalloproteinase inhibitor that is an antagonist of ADAM-10; in a pharmaceutically acceptable carrier.