Patent ID: 8158665

Claim:
A method for the treatment of cholestatic liver disease of liver fibrosis in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a compound according to Formula I: wherein: a is 1, 2, 3, 4 or 5; each R 1 is the same or different and is independently selected from the group consisting of halo, alkyl, alkenyl, —O—CF 3 , —OR 6 , —S(O) f R 6 , —NR 6 R 7 , —R 5 OR 6 , —R 5 S(O) f R 6 , —R 5 NR 6 R 7 and cyano; b is 0, 1, 2 or 3; R 2 is selected from the group consisting of alkyl, alkenyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, —R 5 OR 6 , —R 5 NR 6 R 7 and cyano; Y is —O—, —S— or —N(R 8 )—; R 3 is an acid, amide, ester or acid-equivalent group; R 4 is H, halo, alkyl or haloalkyl; each R 5 is the same or different and is independently selected from the group consisting of alkylene and alkenylene; each R 6 and R 7 are the same or different and are each independently selected from the group consisting of H, alkyl, alkenyl, C 3-6 cycloalkyl and C 3-6 cycloalkenyl; and f is 0, 1 or 2; each R 8 is the same or different and is independently H or alkyl; or a pharmaceutically acceptable salt thereof.