Patent ID: 8609730

Claim:
A method of treating, inhibiting or suppressing, or meliorating symptoms associated with multiple sclerosis, arthritis, diabetes, graft rejection, or a combination thereof in a subject, comprising the step of contacting the subject with a composition comprising a selective c-Rel:DNA binding inhibitor wherein said c-Rel DNA binding inhibitor masks the L1 cavity of the c-Rel protein, thereby treating, inhibiting or suppressing, or ameliorating symptoms associated with inflammatory conditions that are multiple sclerosis, arthritis, diabetes, colitis, lupus, autoimmunity, graft rejection, or a combination thereof in the subject, wherein said composition comprises a compound set forth by the structure of formula (CXIX): wherein R 1 is substituted phenyl or unsubstituted phenyl; R 2 is wherein X 1 , X 2 , or X 3 are independently H, halogen, alkyl, CN, COOH, or NH 2 ; or X 3 forms with the ═N + H 2 a five membered fused ring; or R 2 forms with ═N + H 2 a five or six substituted or unsubstituted membered ring, or their combination.