Patent ID: 7081448

Claim:
A method of treating hyperproliferative vascular disorders in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of formula I having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are each, independently, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, or —SO 3 H; R 9 is hydrogen, CN, NO 2 , halo, CF 3 , alkyl of 1–6 carbon atoms, or alkoxy of 1–6 carbon atoms; R 10 is hydrogen, —NO 2 , —NHR 11 , —NHR 13 , —N(R 13 ) 2 , —NCH 3 R 13 , —NHCO 2 alkyl, wherein the alkyl moiety contains 1–6 carbon atoms, alkylsulfonamide of 1 to 4 carbon atoms, Z is O or S; R 11 is an α-amino acid in which the α carboxyl group forms an amide with the nitrogen of R 10 , wherein if said amino acid is glutamic acid or aspartic acid, the non-α carboxylic acid is an alkyl ester in which the alkyl moiety contains from 1–6 carbon atoms; R 12 is hydrogen, CN, NO 2 , halo, CF 3 , alkyl of 1–6 carbon atoms, alkoxy of 1–6 carbon atoms, or acyl of 2–7 carbon atoms; R 13 is hydrogen, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, or trifluoromethylacyl of 3–8 carbon atoms; or a pharmaceutically acceptable salt thereof.