Patent ID: 7038045

Claim:
A compound represented by the structural formula: or a pharmaceutically acceptable salt, or ester of said compound, wherein: R 1 is selected from the group consisting of H, alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR 6 R 7 , cycloalkyl and cycloalkylalkyl, wherein each of said alkyl, aryl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl and arylalkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, heterocyclyl, trifluoromethyl, OR 6 , NR 6 R 7 , SR 8 , SO 2 R 8 , CN, SO 2 N(R 6 R 7 ) and NO 2 ; R 2 is aikyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, —OR 7 , —SR 7 , hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, alkylcarbonyl, heteroaralkylcarbonyl, or alkylene-N(R 8 R 9 ) (where R 8 and R 9 independently represent H or alkyl, or R 8 and R 9 taken together with the nitrogen in —N(R 8 R 9 ) form a five- to seven-membered heterocycle); R 3 is —NR 4 R 5 , alkyl, alkyithio, aralkylthia, alkylsulfinyl, or araikylsulfinyl; R 4 is aikyl, cycloalkyl or hetemoyclyl, wherein each of said alkyl, cycloalkyl and heterocyclyl can be unsubstituted or optionally independently substituted with 1–4 substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, alkyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, trifluoromethyl, OR 6 , NR 6 R 7 , SR 6 , SO 2 R 6 , CN, SO 2 N(R6R7) and NO 2 ; R 5 is H, alkyl, ary, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl or heteroarylalkyl; R 6 is H, alkyl or aryl; R 7 is H oralkyl; R 10 is halo, alkyl, hydroxyalkyl, trifluoromethyl, OR 6 , NR 6 R 7 , SR 6 , SO 2 R 6 , CN, SO 2 N(R 6 R 7 ) or NO 2 ; and n is 0 to 4, and when n is 2–4, the n moieties can be the same or different, each being independently selected, with the following provisos: (i) that when R 2 is C 1 –C 4 alkyl and R 5 is H, then R 4 is not a C 1 –C 4 alkyl; (ii) that when R 2 is halo, CN, formyl, nitro, alkylcarbonyl, alkylcarbonyl, heteroaralkylcarbonyl, or -alkylene-N(R 8 R 9 ), then: (a) R 3 is not H, alkylthio, aralkylthlo, alkylsulflnyl, aralkylsulfinyl, or —NR 4 R 5 , and (b) n is not 0; and (iii) that when R 2 is alkyl, cycloalkyl, alkenyl or alkynyl, then R 3 is not NH(methyl), N,N(dimethyl), NH(acetyl), N(methyl)(acetyl), H, alkyl, alkyithio, aralkyithio, alkylsulflnyl, or aralkylsulfinyl.