Patent ID: 7557111

Claim:
A thienopyrimidine compound substituted with a cyclic amino group represented by the following formula [I]: wherein the cyclic amino group is represented by the following formula [II]: in which the cyclic amino group is a 3- to 8-membered saturated cyclic amine or a 3- to 8-membered saturated cyclic amine bridged with C 1-5 alkylene or C 1-4 alkylene-O—C 1-4 alkylene between any different two carbon atoms of the cyclic amine, which cyclic amine is substituted with a group represented by —(CR 1 R 2 ) m —(CHR 3 ) n —X, R 4 and R 5 independently on the same or different carbon atoms of the cyclic amine; X is cyano or hydroxy; Y is N; R 1 is hydrogen, hydroxy, C 1-5 alkyl, C 1-5 alkoxy-C 1-5 alkyl or hydroxy-C 1-5 alkyl; R 2 is hydrogen or C 1-5 alkyl; R 3 is hydrogen, cyano, C 1-5 alkyl, C 1-5 alkoxy-C 1-5 alkyl or hydroxy-C 1-5 alkyl; m is an integer selected from 0, 1, 2, 3, 4 and 5; n is 0 or 1; R 4 is hydrogen, hydroxy, hydroxy-C 1-5 alkyl, cyano, cyano-C 1-5 alkyl or C 1-5 alkyl; R 5 is hydrogen or C 1-5 alkyl; R 6 is hydrogen, C 1-5 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-5 alkyl, hydroxy, C 1-5 alkoxy, C 3-8 cycloalkyloxy, halogen, C 1-5 alkylthio or —N(R 12 )R 13 ; R 7 is hydrogen, halogen, C 1-5 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-5 alkyl, hydroxy, C 1-5 alkoxy, C 3-8 cycloalkyloxy, —N(R 14 )R 15 , —CO 2 R 16 , —CON(R 17 )R 18 , cyano, nitro, C 1-5 alkylthio, trifluoromethyl or trifluoromethoxy; Ar is aryl or heteroaryl which aryl or heteroaryl is unsubstituted or substituted with 1 or more substituents, which are the same or different, selected from the group consisting of halogen, C 1-5 alkyl, C 3-8 cycloalkyl, C 2-5 alkenyl, C 2-5 alkynyl, C 1-5 alkoxy, C 1-5 alkylthio, C 1-5 alkylsulfinyl, C 1-5 alkylsulfonyl, cyano, nitro, hydroxy, —CO 2 R 19 , —C(═O)R 20 , —CONR 21 R 22 , —OC(═O)R 23 , —NR 24 CO 2 R 25 , —S═) r NR 26 R 27 , trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoromethoxy, methylenedioxy, ethylenedioxy and —N(R 28 )R 29 ; R 12 , R 13 , R 14 and R 15 are the same or different, and independently are hydrogen or C 1-5 alkyl; R 16 , R 19 and R 25 are the same or different, and independently are hydrogen or C 1-5 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-5 alkyl, aryl or aryl-C 1-5 alkyl; R 17 , R 18 , R 20 , R 21 , R 22 , R 23 , R 24 , R 26 , R 27 , R 28 and R 29 are the same or different, and independently are hydrogen, C 1-5 alkyl or C 3-8 cycloalkyl; r is 1 or 2 or pharmaceutically acceptable salts thereof.