Patent ID: 7393674

Claim:
A composition consisting essentially of: 0.1 mg/mL to 5.0 mg/mL thrombin; 2% to 4% (w/v) sucrose; 3.5% to 5% (w/v) mannitol; 50 mM to 300 mM NaCt; 0-5 mM CaCl2; 0.03% to 1% (w/v) of a surfactant or high-molecular-weight polyethylene glycol; and a physiologically acceptable buffer, in aqueous solution at pH 5.7-7.4, wherein concentration of the buffer is selected to provide approximately physiological pH upon application of the composition in a surgical setting; wherein the ratio of mannitol:sucrose is greater than 1:1 but not greater than 2.5:1 (w/w) and wherein the molar ratio of sucrose:thrombin is at least 700:1.