Patent ID: 7262164

Claim:
A compound of the formula wherein: R 1 is a polymeric residue having an average molecular weight of from about 2,000 to about 100,000; Y 1 is O, S or NR 10 ; M is O, S or NR 11 ; E 1 is E 2-4 is are independently H, E 1 or (a) is zero or one; (m) is zero or a positive integer, (w) is zero or one; (n) and (p) are independently 0 or a positive integer; Y 2-3 are independently O, S or NR 12 ; R 2-11 and R 15 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy, D 1 and D 2 are independently OH, wherein: R′ 4 and R′ 5 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; E 35 is E 36-38 are independently H, E 35 , or and D′ 1 and D′ 2 are independently OH, or, wherein: R″ 4 and R″ 5 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; E 45 is E 46-48 are independently H, E 45 , or and D″ 1 and D″ 2 are independently OH, (v) and (t) are independently 0 or 1; L 1 and L 2 are independently selected linkers; Y 4-5 are independently selected from the group consisting of O, S and NR 16 ; R 12-14 and R 16 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; Ar is a moiety which when included in Formula (Ib) forms a multisubstituted aromatic hydrocarbon or a multi-substituted heterocyclic group; and B 1 and B 2 are independently selected from the group consisting of OH, and residues of sulfhydryl-containing moieties provided that w is not zero when is CH 2 COOH.