Patent ID: 7645583

Claim:
A method for identifying a gibberellic acid or a jasmonic acid compound that inhibits the complexation of C-reactive protein with fibronectin, the method comprising: contacting a first polypeptide with a second polypeptide in the presence of a gibberellic acid or jasmonic acid test compound to form a complex of the first polypeptide with the second polypeptide, the first polypeptide comprising at least a segment of a C-reactive protein, the first polypeptide including the fibronectin binding site of the C-reactive protein and the second polypeptide comprising at least a segment of a fibronectin protein, the second polypeptide including the C-reactive binding site of the fibronectin; and determining whether complexation of the first polypeptide with the second polypeptide is decreased in the presence of said gibberellic acid or jasmonic acid test compound as compared to a control containing no gibberellic acid or jasmonic acid compound, wherein the first polypeptide and the second polypeptide form a complex in the absence of gibberellic acid or jasmonic acid compound and a decrease in said complexation is an indication that said gibberellic acid or jasmonic acid compound inhibits the complexation of C-reactive protein to fibronectin.