Patent ID: 7063782

Claim:
A method for in vitro detection or measurement of albumin derivatives, which can be diagnostic of an ischemic event, said method comprising: a) providing a patient sample comprising albumin and/or derivatives thereof in a vessel that is connected to an electrochemistry apparatus; b) operating the electrochemistry apparatus to utilize an electrochemical technique; c) optionally measuring a background characteristic electrochemical output signal of the sample; d) adding a known amount of a transition metal ion to the sample, whereby at least some of the ion binds to albumin metal sequestering sites and remaining ion is non-sequestered; e) optionally adding an indicator or amplifier to the sample to bind to the non-sequestered ion; f) measuring a characteristic electrochemical output signal associated with the non-sequestered ion; g) optionally using a standard curve to convert the measured output signal of step (f) to a converted value; whereby the measured electrochemical output signal or the converted value, if it exceeds a predetermined value, can be diagnostic of an ischemic event.