Patent ID: 8012476

Claim:
A modified IgG comprising an IgG constant domain, wherein the IgG constant domain comprises a human IgG CH3 domain in which there is an amino acid substitution at amino acid residues 433, 434 and 436 relative to a corresponding IgG comprising a wild-type human IgG CH3 domain, numbered according to the EU numbering index of Kabat, wherein the modified IgG has an increased half-life compared to the half-life of the corresponding IgG comprising the wild-type human IgG CH3 domain, and wherein the substitution at amino acid residue 433 is a substitution with a lysine, the substitution at amino acid residue 434 is a substitution with a phenylalanine, and the substitution at amino acid residue 436 is a substitution with a histidine.