Patent ID: 7939629

Claim:
A peptide-resin conjugate A-W, wherein A=P-X1-Asp(R4)-Phe-Glu(R5)-Glu(R6)-Ile-Pro-Glu(R7)-Glu(R8)-Tyr(R9)-X2 (SEQ ID NO:3), wherein X1 is a peptidyl moiety of 0 to 200 amino acids, X1 optionally comprising protection groups on individual amino acid side chains, wherein R9 is an amino side chain protection group and wherein X2 is a single amino acid residue linked to the solid phase via —O— and optionally being side chain or C-terminally protected, and wherein P is H or is a protection group selected from the group consisting of Boc, Fmoc, Dde, Nps, Alloc, Z, and R4, R5, R6, R7 and R8 are amino acid side chain protection groups, and wherein W is a solid phase composite comprising a resin handle or linker a) of the formula II with the proviso that then A, where including a residue X2, is always linked via —O— to said handle or linker, and wherein R′″ is a solid phase, and wherein R″ 1 , R″ 2 , R″ 3 are, independently, H, 4-(C 1 -C 4 alkyl) or 4′-(C 1 -C 4 alkyl) or 4-(C 1 -C 4 alkoxy) or 4′-(C 1 -C 4 alkoxy), and may be the same or different with the proviso that only one of R″ 1 , R″ 2 may be H, and wherein R″ 2 may optionally be 2-Cl with the proviso that then R″ 1 is H, b) or of the formula III with the proviso that then A, where including a residue X2, is linked via —O— to said handle or linker, R′″ being defined as above, c) or of the formula IV wherein R′″ is defined as above and R″ 1 , R″ 2 , R″ 3 are, independently, H, C 1 -C 4 alkyl or C 1 -C 4 alkoxy, and may be the same or different with the provisio that only one of R″ 1 , R″ 2 may be H, and wherein L is A(L=A) or wherein L is of formula V and wherein W allows of cleaving the peptide moiety under weakly acidic conditions of 0.1% to 30% trifluoroacetic acid.