Patent ID: 8747861

Claim:
A synthetic or a recombinant influenza multi-epitope polypeptide comprising multiple copies of a plurality of influenza virus peptide epitopes wherein the polypeptide is selected from the group consisting of: i. (X 1 ZX 2 Z . . . X m ) n ; and ii. (X 1 ) n Z(X 2 ) n Z . . . (X m ) n ; wherein n is at each occurrence independently an integer of 3-6; m is 9; X 1 , X 2 . . . X m are influenza peptide epitopes consisting of HA 354-372 (E1, SEQ ID NO: 82), HA 91-108 (E2, SEQ ID NO: 48), M1 2-12 (E3, SEQ ID NO: 25), HA 150-159 (E4, SEQ ID NO: 52), HA 143-149 (E5, SEQ ID NO: 51), NP 206-229 (E6, SEQ ID NO: 64), HA 307-319 (E7, SEQ ID NO: 59), NP 335-350 (E8, SEQ ID NO: 69), and NP 380-393 (E9, SEQ ID NO: 70); Z at each occurrence is a bond or a spacer of 1 to 4 neutral amino acid residues.