Patent ID: 8586730

Claim:
A process for making the compound of formula (Ia): wherein, n=0 to 4; X=a direct bond, —CH 2 —CH 2 —O—, or —CH 2 —CH 2 —CH 2 —O—; Z═H, —CH 2 —CH 2 —OH, —CH 2 —CH 2 —CH 2 —OH, —SO 3 H, —SO 3 M, —PO 3 H 2 , —PO 3 M, or —PO 3 M 2 ; R=a retinoid or a carotenoid; and M=Na, K, Ca, Mg, Ba, Zn, Mn, Cu, Fe, Co, or Ni, wherein the method comprises the steps of: (i) mixing a polyene aldehyde and an organic solubilizing liquid until a transparent mixture is obtained; (ii) adding a suitable cyclodextrin and water to the transparent mixture and mixing for 1-120 hours under a nitrogen or argon atmosphere to form a reaction mixture; and (iii) drying the reaction mixture to a powder.