Patent ID: 8802661

Claim:
A compound which is selected from the group of: a compound of formula I a compound of formula II a compound of formula III wherein R 1 is isopropenyl or isopropyl; J and E are —H or —CH 3 ; E is absent when the double bond is present; X is a phenyl or heteroaryl ring substituted with A, wherein A is at least one member selected from the group of —H, -halo, -alkyl, -alkoxy, —COOR 2 and -hydroxyl wherein R 2 is —H—C 1-6 alkyl, or substituted —C 1-6 alkyl; Y is selected from the group of —COOR 2 , —C(O)NR 2 SO 2 R 3 , —C(O)NR 2 SO 2 NR 2 R 2 , —SO 2 NR 2 R 2 , —NR 2 SO 2 R 2 , —C 1-6 cycloalkyl-COOR 2 , —C 1-6 alkenyl-COOR 2 , —C 1-6 alkynyl-COOR 2 , —C 1-6 alkyl-COOR 2 , —NHC(O)(CH 2 ) n —COOR 2 , —SO 2 NR 2 C(O)R 2 , -tetrazole, B(OH) 2 and —CONHOH wherein n=1-6 and wherein R 3 is C 1-6 alkyl; and Z is —CONR 4 R 5 ; R 4 is selected from the group of H, C 1-6 alkyl, and C 1-6 alkyl-OH; R 5 is selected from the group of H, C 1-6 alkyl, substituted-alkyl, C 1-6 alkyl-R 6 , C 2-6 alkyl-R 7 , SO 2 R 8 , SO 2 NR 9 R 10 ; R 6 is selected from phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, SO 2 R 11 , SO 2 NR 12 R 13 , C 1-6 cycloalkyl, substituted C 1-6 cycloalkyl, SO 3 H, COOR 14 , C(O)NR 15 R 16 ; R 7 is selected from OR 17 , N + (O − )R 18 R 19 , NR 20 (COR 21 ) and NR 22 R 23 ; or R 4 and R 5 are taken together to form a cycle selected from the group of: R 22 and R 23 are selected from the group of H, C 1-6 alkyl, substituted-alkyl, C 1-6 alkyl-R 32 , C 2-6 alkyl-R 33 , SO 2 R 8 , SO 2 NR 9 R 10 ; R 32 is selected from phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, SO 2 R 11 , SO 2 NR 12 R 13 , C 1-6 cycloalkyl, substituted C 1-6 cycloalkyl, SO 3 H, COOR 14 , C(O)NR 15 R 16 , R 33 is selected from OR 17 , N + (O − )R 18 R 19 , NR 20 (COR 21 ) and NR 9 R 10 ; or R 22 and R 23 are taken together to form a cycle selected from the group of: R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 27 , R 29 , R 30 and R 31 are each independently selected from the group of H, C 1-6 alkyl, substituted-alkyl, C 1-6 cycloalkyl and substituted C 1-6 cycloalkyl; R 24 , R 26 and R 28 are selected from the group of H, alkyl, substituted alkyl, COOR 29 , COONR 30 R 31 ; and R 25 is selected from the group of alkyl, substituted alkyl, COOR 29 , COONR 30 R 31 ; and pharmaceutically acceptable salts thereof.