Patent ID: 7504399

Claim:
A compound of Formula I, or pharmaceutically acceptable salts thereof, wherein: A is selected from the group consisting of: R 1 is hydrogen or C 1 -C 4 alkyl; R 2 is hydrogen; R 4 is selected from the group consisting of hydrogen, halogen, hydroxy, and O(C 1 -C 4 alkyl); R 5 is hydrogen, halogen, or (C 1 -C 4 alkyl); R 6 is selected from the group consisting of hydrogen, halogen, halogen, or (C 1 -C 4 alkyl); R 7 is independently selected from the group consisting of hydrogen, halogen, and B; R 4N does not exist; wherein — —represents a carbon-carbon bond or does not exist; U and V are independently selected from hydrogen, cyano, COOH, phenyl or pyridyl with the proviso that at least one must be cyano or COOH; Z is selected from the group consisting of CF 3 , C 4 -C 7 alkyl, phenyl, C 4 -C 7 cycloalkyl, C 4 -C 7 cycloalkenyl, pyridinyl, C 2 -C 5 alkoxy, a 5 membered monocyclic heteroaryl containing 1 to 2 nitrogens, an N linked 6 membered heteroalicyclic containing 1 or 2 nitrogens, a C 4 -C 6 lactam attached via the lactam nitrogen, or cyano wherein said aryl or heteroaryl or lactam are independently optionally substituted with one to two groups selected from halogen or C 1 -C 3 alkyl; B is selected from the group consisting of chloro, methoxy, tetrazolyl, -triazolyl, pyrazolyl, imidazolyl, pyrrolyl, pyrazinyl, and XR 8a , wherein said are optionally substituted with one to three same or different halogens or from one to three same or different substituents selected from the group F; F is selected from the group consisting of (C 1-3 )alkyl, heteroalicyclic, hydroxymethyl, halogen, —COOH, —COO(C 1-3 )alkyl, amino, —NHCH 3 , —N(CH 3 ) 2 , R 8a is a member selected from the group consisting of C(O)CH 3 , C(O)NH 2 , C(O)NHCH 3 , and C(O)N(CH 3 ) 2 ; R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , are each independently selected from the group consisting of hydrogen and methyl; with the proviso that no more than two can be methyl; X is selected from the group consisting of NH and NCH 3 .