Patent ID: 7202246

Claim:
A compound having a structure of Formula I: wherein, R 1 is hydrogen, (C 1–C 6 )alkyl, substituted (C 1 –C 6 )alkyl, —C(O)CH 2 R 10 , or —C(O)NR 11 R 12 , wherein R 10 is hydrogen, halogen, hydroxyl, amino, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, (C 1 –C 6 )alkylthio, (C 1 –C 6 )acyloxy, (C 1 –C 6 )alkylamino, di(C 1 – 6 )alkylamino, aryl, heteroaryl, or -L 25 -Q 25 , wherein L 25 is a linker group and Q 25 is an antibacterial pharmacophore selected from quinolones, macrolides, oxazolidinones, and β-lactams, and wherein R 11 and R 12 independently are the same or different and are hydrogen, (C 1 –C 6 )alkyl, substituted (C 1 –C 6 )alkyl, or -L 25 -Q 25 , or R 11 and R 12 , together with the nitrogen atom to which they are attached, form a 3-to 8-membered heterocyclic ring, optionally containing up to two heteroatoms, wherein one or more of the carbon or nitrogen atoms of the heterocyclic ring is optionally substituted by (C 1 –C 6 )alkyl or -L 25 -Q 25 ; one of Y 1 and Y 2 is —OH and the other is hydrogen, or Y 1 and Y 2 together with the carbon to which they are attached are C═O or C═N—O—R 21, wherein R 21 is hydrogen, (C 1 –C 6 )alkyl or -L 11 -Q 11 , wherein L 11 is a linker group and Q 11 is an antibacterial pharmacophore selected from quinolones, macrolides, oxazolidinones, and β-lactams; X is —CR 31 R 32 —, —NR 33 —, —S—or —O—, wherein R 31 , R 32 and R 33 independently are the same or different and are hydrogen or (C 1 –C 6 )alkyl, and m and n independently are the same or different and are an integer between 1 and 3; and Z is —NR 41 —, —CR 42 R 43 —, —O—, or —S(O) p —, wherein p is an integer between 0 and 2, R 41 is hydrogen, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkyl sulfonyl, aryl sulfonyl, (C 1 –C 6 )alkoxycarbonyl, aryloxycarbonyl, (C 1 –C 6 )alkyl amino carbonyl, aryl amino carbonyl, which are all optionally substituted, or -L-Q, wherein L is a linker group comprising any combination of from 1 to 5 groups selected from (C 1 –C 6 )alkylene, (C 3 –C 8 )cycloalkylene, arylene, heteroarylene, bivalent heterocyclic group containing 1 to 3 heteroatoms, —C(═O)—, —C(═N—(O)—R 13 )—, —C═N—, —O—, —S(O) n —, and —N(R 14 )—, wherein n is an integer between 0 and 2, the carbon or nitrogen atoms of the linker group are optionally substituted by 1 to 3 substituents selected from (C 1 –C 6 )alkyl, amino, (C 1 –C 6 )alkylamino, di(C 1 –C 6 )alkylamino, hydroxyl, (C 1 –C 6 )alkoxy, and heterocyclic group,R 13 and R 14 are independently the same or different and are hydrogen, (C 1 –C 6 )alkyl, aryl, heteroaryl, or heterocyclic group, and Q is an antibacterial pharmacophore selected from quinolones, macrolides, oxazolidinones, and β-lactams, and R 42 and R 43 independently are the same or different and are hydrogen, hydroxyl, amino, carboxyl, halo, cyano, (C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkyl, (C 1 –C 6 )heteroaryl, or heterocyclic group.