Patent ID: 6846814

Claim:
A compound having the formula wherein: R 1a is H, NR 9 R 10 , —OR 10 , Cl, Br, R 1b and R 1c are independently H or —OR 9 , or R 1b and R 1c together are ═O, ═CH 2 or —OCH 2 CH 2 O—; R 2 is H, oxo, —OR 9 or —CH 3 ; R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently selected from H, cyano, nitro, trifluoromethoxy, trifluoromethyl, C 1-6 alkylsulfonyl, halo, —OR 9 , —OCH 2 O—, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(═O)OR 9 , —C(═O)NR 9 R 10 , —OC(═O)R 9 , —NR 9 C(═O)R 10 , aminosulfonyl and C 1-6 alkyl substituted by any of the hereinabove substituents; wherein at least two of R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are H; R 9 is independently selected From H, C 1-6 alkyl, C 1-4 alkoxy, and —OCH 2 (CH 2 ) n phenyl; R 10 is independently H or C 1-6 alkyl, hydroxyC 1-6 alkyl, (NR 9 R 9 )C 1-6 alkyl, (NR 9 R 9 )C(═O)C 1-6 alkyl, —(CH 2 ) o R 15 ; R 11 is phenyl, substituted in at least the ortho position by C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, trifluoromethylthio, trifluoromethylsulfinyl, C 1-6 alkanesulfonamido, C 1-6 alkanoyl, C 1-6 alkoxy-carbonyl, succinamido, carbamoyl, C 1-6 alkylcarbamoyl, di-C 1-6 alkylcarbamoyl, C 1-6 alkoxy-CC 1-6 alkylcarbamoyl, N-methylcarbamoyl, C 1-6 alkanoylamino, ureido, C 1-6 ureido, di-C 1-6 alkylureido, amino, C 1-6 alkylamino, or di-C 1-6 alkylamino; R 12 is selected from hydrogen, hydroxy, C 1-6 alkoxy, C 1-6 alkanoyloxy, C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, C 1-6 alkanoylamino, C 1-6 alkyl, carbamoyl, C 1-6 alkylcarbamoyl and bis(C 1-6 alkyl)carbamoyl; R 13 is —CH 2 CH 2 —, CH 2 CH 2 CH 2 — or —CH 2 CH 2 CH 2 CH 2 —; R 14 is hydrogen, hydroxy, C 1-6 alkoxy, C 1-6 alkanoyloxy, C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, C 1-6 alkanoylamino, C 1-6 alkyl, carbamoyl, C 1-6 alkylcarbamoyl or di-C 1-6 alkylcarbamoyl; R 15 is a 5- or 6-membered saturated or unsaturated heterocycle containing 1 or 2 heteroatoms selected from nitrogen, oxygen and sulfur and additionally subsituted with 0 or 1 oxo groups; or R 15 is phenyl substituted by 0, 1, or 2 substituents selected from halogen, C 1-4 alkoxy, vicinal-methylenedioxy, —S(═O) n C 1-4 alkyl, —S(═O) 2 NH 2 and C 1-4 alkyl; M is —C(═O)— or —S(═O) 2 —; L is —NH— or —CH 2 —; X 1 and X 2 are independently H or halogen, wherein at least one of X 1 and X 2 are halogen; Y and Z are independently selected from CH 2 , O, S, S═O and S(═O) 2 , wherein at least one of Y and Z is CH 2 ; n is independently, at each instance, 0 or 1; o is independently, at each instance, 1, 2 or 3; and any pharmaceutically-acceptable salt thereof.