Patent ID: 7375136

Claim:
A method of treating neurodegeneration associated with a pathological condition characterized by lowered brain-tissue pH, said method comprising administering to a patient in need of such treatment a pharmaceutically effective amount of a compound having enhanced NMDA receptor blocking activity at said lowered brain-tissue pH over normal brain-tissue pH, said compound being selected from the group consisting of (R)- or (S)-enantiomers and racemic mixtures of a compound of the formula: wherein one of R 9 , R 10 , R 11 , R 12 and R 18 is wherein R 13 is alkyl, aralkyl or aryl; R 17 is H or lower alkyl; and the others of R 9 , R 10 , R 11 , R 12 and R 18 are H, F, Cl, Br, I or lower alkyl; wherein A is wherein R 1 and R 5 are independently H or F; R 2 , R 3 and R 4 are independently selected from the group consisting of H, F, Cl, Br, I and O(lower alkyl); or R 2 and R 3 taken together are O—CH 2 —O; and B is wherein R 6 and R 6 ′ are independently H or F; and R 7 is CH 2 Ar, CH 2 CH 2 Ar, CH 2 CHFAr, or CH 2 CF 2 Ar, where Ar is 2,3,4,5,6-pentafluorophenyl; and R 8 is OH, or O(lower alkyl); and pharmaceutically acceptable salts, enantiomers, enantiomeric mixtures, and mixtures of the foregoing.