Patent ID: 7351531

Claim:
A method for forming a mimetic base pair at a base pair that fails to form any normal base pair among the base pairs of a single-stranded oligonucleotide chain comprising the steps of: (1) providing a compound represented by the formula A-L-B, wherein A represents a chemical structural moiety capable of forming a pair with one base of the base pair that fails to form a normal base pair, B represents a chemical structural moiety capable of forming, a pair with another base of the base pair that fails to form a normal base pair, and L represents a linker structure that binds the moieties A and B; and wherein said compound is characterized to form a mimetic base pair in a single-stranded oligonucleotide chain by a hydrogen bond formed between bases and the moieties A and B and a stabilization of the moieties A and B results from a stacking effect derived from the bases in the vicinity of the moiety B, and (2) forming the mimetic base pair at a base pair that fails to form a normal base pair among the base pairs of a single stranded oligonucleotide chain.