Patent ID: 8618151

Claim:
A compound having formula IIIe: or a pharmaceutically acceptable salt thereof, wherein: X and Xâ€² are each â€”CH 2 â€”; X b and X c are each â€”Câ€”; each R a is hydrogen; each r is 3; Z and Zâ€² are each independently â€”Uâ€”(CR 4 2 ) t â€”NR 5 â€”Uâ€”Oâ€”R 8 , wherein, each U is independently selected from the group consisting of â€”C(O)â€”, â€”C(S)â€” and â€”S(O) 2 â€”, each R 4 and R 5 is independently selected from the group consisting of hydrogen, C 1 to C 8 alkyl, C 1 to C 8 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl and aralkyl, R 8 is hydrogen or C 1 to C 8 alkyl, and t is independently 0, 1, 2, 3, or 4.