Patent ID: 7034027

Claim:
A compound having a formula wherein R 0 , independently, is selected from the group consisting of halo and C 1-6 alkyl; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-3 alkyl, arylC 1-3 alkyl, and heteroarylC 1-3 alkyl; R 2 is selected from the group consisting of substituted benzene, an optionally substituted monocyclic aromatic ring selected from the group consisting of thiophene, furan, and pyridine, and an optionally substituted bicyclic ring wherein the fused ring A is a 5- or 6-membered ring, saturated or partially or fully unsaturated, and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulfur, and nitrogen; X is CR 3 R 4 ; R 3 is selected from the group consisting of hydrogen and C 1-3 alkyl; R 4 is selected from the group consisting of haloC 1-4 alkyl, aryl, heteroaryl, Het, C 3-8 cycloalkyl, OR a , C(═O)OR a , C(═O)R a , C(═O)NR a SO 2 R b , C(═O)NR a R b , C(═S)NR a R b , C 1-6 alkyleneC(═O)OR a , C 1-4 alkyleneC(═O)NR a R b , C 1-4 alkyleneNR a R b , C 1-4 alkyleneOR a , C 1-4 alkyleneSO 2 NR a R b , C 1-4 alkyleneheteroaryl, C 1-4 alkyleneHet, C 1-4 alkyleneC(═O)C 1-4 alkyleneHet, C 1-4 alkyleneC(═O)Het, C 1-4 alkyleneC(═O)OR a , C(═O)C 1-4 alkyleneHet, C(═O)NR a alkyleneOR b , C(═O)NR a C 1-4 alkyleneHet, NR a C 1-4 alkyleneNR a R b , NR a C(═O)R b , NR a C(═O)NR a R b , N(SO 2 C 1-4 alkyl) 2 , and NR a (SO 2 C 1-4 alkyl), with the proviso that when R 3 is hydrogen, R 4 is different from aryl; or R 3 and R 4 together represent a 4- to 6-membered alkyl or alkenyl chain component of a 5- to 7-membered ring; R a and R b , independently, are selected from the group consisting of hydrogen, C 1-8 alkyl, aryl, heteroaryl, haloC 1-6 alkyl, C 1-4 alkyleneHet, arylC 1-3 alkyl, heteroarylC 1-3 alkyl, C 1-4 alkylenearyl, C 3-8 cycloalkyl, C 1-3 alkyleneheteroaryl, and Het; Het is a 4- to 7-membered heterocyclic group, saturated or partially unsaturated, containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, and optionally substituted with one or more C 1-6 alkyl, NR a R b , and C(═O)OR a ; q is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt or hydrate thereof.