Patent ID: 8778963

Claim:
A compound of the Formula (II): wherein: Z is —C(═N—O—R 1-2 )— X is: —CH(R 9 )—, or —CH(R 9 )-alkylene-; R 1-1 is selected from the group consisting of: hydrogen, alkyl, and aryl; R 1-2 is selected from the group consisting of: hydrogen, alkyl, heterocyclyl, aryl, heteroaryl, and alkyl, heterocyclyl, aryl, or heteroaryl, substituted by one or more substituents selected from the group consisting of: halogen, cyano, alkyl, hydroxy, hydroxyalkyl, alkoxy, dialkylamino, heterocyclyl, aryl, and heteroaryl; R is selected from the group consisting of: halogen, hydroxy, alkyl, alkenyl, haloalkyl, alkoxy, alkylthio, and —N(R 9 ) 2 ; R 2 is selected from the group consisting of: hydrogen; alkyl; alkoxyalkyl; and hydroxyalkyl; R 3 is selected from the group consisting of: aryl, heteroaryl, and aryl and heteroaryl substituted by one or more of the groups selected from halogen, hydroxyl, alkoxy, hydroxyalkyl, cyano, dialkylamino, heterocyclyl, —C(O)NH 2 , —NHS(O) 2 -alkyl, —C(O)NH-alkyl, —NHC(O)-alkyl, —C(O)NH-heterocyclyl, and R 6 is selected from the group consisting of ═O and ═S; R 8 is selected from the group consisting of hydrogen, C 1-10 alkyl, C 2-10 alkenyl, C 1-10 alkoxy-C 1-10 alkylenyl, hydroxy-C 1-10 alkylenyl, heteroaryl-C 1-10 alkylenyl, and aryl-C 1-10 alkylenyl; R 9 is selected from the group consisting of hydrogen and alkyl; A is selected from the group consisting of —O—, —C(O)—, —S(O) 0-2 —, and —CH 2 —; V is selected from the group consisting of —C(R 6 )—, —O—C(R 6 )—, —N(R 8 )—C(R 6 )—, and —S(O) 2 —; a and b are each independently integers from 1 to 6 with the proviso that a+b is ≦7; n′ is an integer from 0 to 4; and m is 0 or 1; with the proviso that when m is 1, then n′ is 0 or 1; or a pharmaceutically acceptable salt thereof.