Patent ID: 7915424

Claim:
A compound of formula 1: wherein Ar is 2-chlorophenyl, 3-chlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3,4-dimethylphenyl, 3,5-dimethylphenyl, 2,4-dimethylphenyl, 2,5-dimethylphenyl, 2-cyanophenyl, 3-cyanophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-chlorophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3,4,5-trifluorophenyl, 3-bromophenyl, 3-nitrophenyl, 3-trifluoromethylphenyl, 3-aminophenyl, 3-chloro-4-fluorophenyl, 3-hydroxyphenyl, 3-acetylphenyl, 5-chloro-2-methoxyphenyl, 3-chloro-4-methoxyphenyl, 3-hydroxy-4-fluorophenyl, 3-methoxy-4-fluorophenyl, 3-ethoxy-4-fluorophenyl, 3-isopropoxy-4-fluorophenyl, 3-isopropylphenyl, 3-ethylphenyl, 3-methyl-4-fluorophenyl, 3-trifluoromethyl-4-fluorophenyl, 3-cyano-4-fluorophenyl, 3-amino-4-fluorophenyl, 3-trifluoromethyl-4-fluorophenyl, 3-chloro-4-fluorophenyl, 3-nitro-4-fluorophenyl, 3-aminocarbonyl-4-fluorophenyl, 3-N-methylaminocarbonyl-4-fluorophenyl, 3-N,N-dimethylaminocarbonyl-4-fluorophenyl, 3-carboxyl-4-fluorophenyl, 3-methoxycarbonyl-4-fluorophenyl, 3-acetylaminomethyl-4-fluorophenyl, 3-methysulfonylaminomethyl-4-fluorophenyl, 3-pivaloylaminomethyl-4-fluorophenyl, 3-trifluoromethoxyphenyl, 3-aminomethyl-4-fluorophenyl, 3-dimethylaminomethyl-4-fluorophenyl, 3-cyanomethyl-4-fluorophenyl, 4-fluoro-3-hydroxymethylphenyl, 3-{[(2-cyanoethyl)-methylamino]-methyl}-4-fluorophenyl, 4-fluoro-3-[(isopropylmethylamino)-methyl]phenyl, 4-fluoro-3-isopropylaminomethylphenyl, 4-fluoro-3-propylaminomethylphenyl, 3-ethylaminomethyl-4-fluorophenyl, 4-fluoro-3-methyl aminomethylphenyl, or 3-isobutyrylamino-4-fluorophenyl; R 1 is CN, iodo, chloro, methyl or COR 3 ; R 2 is 1,2-ethynediyl; and R 3 is hydrogen or C 1 -C 4 alkyl; or a pharmaceutically acceptable salt thereof; or an N-oxide thereof.