Patent ID: 8420802

Claim:
A polymer support characterized in that the polymer is 6-amino 6-deoxy chitosan, wherein a linker is provided on at least some of the amine groups of the polymer and wherein the linker is introduced as a heterobifunctional moiety capable of covalent coupling with the amino functional groups of the polymer on one end and a functional molecule on the other end and wherein the heterobifunctional moiety is selected from the group consisting of succinimidyl acetylthioacetate, succinimidyl trans-4-(maleimidylmethyl) cyclohexane-1-carboxylate, succinimidyl 3-(2-pyridyldithio)propionate, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, N-((2-pyridyldithio)ethyl)-4-azidosalicylamide, 4-azido-2,3,5,6-tetrafluorobenzoic acid, succinimidyl ester, benzophenone-4-maleimide, benzophenone-4-isothiocyanate, 4-benzoylbenzoic acid, succinimidyl ester, iodoacetamide azide, iodoacetamide alkyne, azido (PEO) 4 propionic acid, succinimidyl ester, alkyne, succinimidyl ester, alpha-maleimidoacetic acid-NHS, 2-maleimidoethyl amine.TFA, 3-maleimidopropionic acid NHS, 3-maleimidopropionic acid-PFP ester, 4-maleimidobutyric acid NHS, 6-maleimidocaproic acid NHS, 6-[N-(6-maleimidocaproyl)]caproic acid NHS, 6-maleimidocaproic acid sulfo-NHS, 6-maleimidocaproic acid (2-nitro-4-sulfo) phenyl ester sodium salt, 11-maleimidoundecanoic acid sulfo-NHS, succinimidyl 6-[(3-maleimido)propionamido]-hexanoate, LC-SMPH, b-maleimidopropionic acid hydrazide, e-maleimidocaproic acid hydrazide, 11-maleimidoundecanoic acid hydrazide, 3-maleimidopropionic acid, 4-maleimidobutyric acid, 6-maleimidocaproic acid, 11-maleimidoundecanoic acid, SMCC, sulfo-SMCC, SMCC hydrazide, LC-SMCC, m-maleimidobenzoyl N-hydroxysuccinimide, sulfo-MBS-1, p-maleimidobenzoyl N-hydroxysuccinimide, succinimidyl-(4-vinylsulfonyl)benzoate, N-succinimidyl-(4-iodoacetyl) aminobenzoate, sulfo-SIAB, p-maleimidophenylisocyanate, N-succinimidyl S-acetylthioacetate, N-succinimidyl S-acetylthiopropionate, succinimidyl 3-bromoacetamido)propionate, succinimidyl iodoacetate, succinimidyl bromoacetate, succinimidyl 4-(p-maleimidophenyl)butyrate, succinimidyl-p-formyl-benzoate, pyridine dithioethylamine hydrochloride, 4-(N-maleimido)benzophenone, 4-(N-succinimidylcarboxy)benzophenone, 4-(N-iodoacetyl)benzophenone, (N-succinimidyl 3[2-pyridyldithio]propionate), (3-[2-pyridyldithio]propionyl hydrazide), succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate, sulfo-succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate, succinimidyl-4-[2-(tert-butoxycarbonyl)hydrazino]benzoate, succinimidyl-4-[2-(tert-butoxycarbonyl)hydrazino]acetate, 2-iminothiolane hydrochloride, S-acetylmercaptosuccinic anhydride, 6-(N-trifluoroacetyl)caproic acid NHS, 6-(N-t-BOC)caproic acid NHS, succinimidyl-6-(iodoacetyl)aminocaproate, and methyl N-succinimidyl adipate and combinations thereof.