Patent ID: 7829102

Claim:
An infectious chimeric respiratory syncytial virus (RSV) comprising a major nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large polymerase protein (L), a RNA polymerase elongation factor (M2ORF1), and a partial or complete human-bovine chimeric RSV genome or antigenome comprising a RSV background genome or antigenome of a bovine RSV wherein human RSV glycoprotein genes F and G are substituted to replace the counterpart F and G glycoprotein genes in said partial bovine RSV background genome or antigenome and wherein said human RSV glycoprotein genes F and G are substituted at a position that is more promoter-proximal as compared to the position of said glycoprotein genes F and G in a wild type bovine RSV genome or antigenome.