Patent ID: 6881746

Claim:
A compound of the general formula (I): wherein A is X is a valence bond, —CR 1 R 2 —or —NR 1 —, Y is >CR 3 — or >N—, R 1 , R 2 and R 3 independently are hydrogen or C 1-6 -alkyl, or R 1 and R 3 on adjacent atoms may be combined to form a double bond, E is C 1-10 -alkyl or C 2-10 -alkenyl, C 3-10 -cycloalkyl, C 3-10 -cycloalkenyl, C 7-10 -bicycloalkyl, C 3-10 -cycloalkyl-C 1-6 -alkyl, C 3-10 -cycloalkenyl-C 1-6 -alkyl or C 7-10 -bicycloalkyl-C 1-6 -alkyl, wherein the rings may optionally be substituted with one or more substituents selected from halogen, C 1-6 -alkyl, C 2-6 -alkenyl, C 1-6 -alkoxy, C 1-6 -thioalkyl, —CF 3 , —OCF 3 , —SCF 3 , —OCHF 2 and —SCHF 2 , aryl, aryloxy, arylthio, aryl-C 1-6 -alkyl, aryloxy-C 1-6 -alkyl, arylthio-C 1-6 -alkyl, diaryl-C 1-6 -alkyl or (C 1-6 -alkyl)(aryl)-C 1-7 -alkyl, wherein the non-aromatic and aromatic rings may optionally be substituted with one or more substituents selected from halogen, C 1-6 -alkyl, C 2-6 -alkenyl, C 1-6 -alkoxy, C 1-6 -thioalkyl, —CF 3 , —OCF 3 , —SCF 3 , —OCHF 2 , —SCHF 2 , C 3-10 -cycloalkyl and C 3-10 -cycloalkenyl, or with two substituents on adjacent positions which are combined to form a bridge C 1-6 -alkylene, C 2-6 -alkenylene or —O—C 1-6 -alkylene-O—, B is X′ is —CR 8 ═, Y′ is —S—, R 8 is hydrogen, C 1-6 -alkyl or aryl, wherein aryl is optionally substituted with one or two substituents selected from halogen, C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -thioalkyl, —CF 3 , —OCF 3 , —SCF 3 , —OCHF 2 , —SCHF 2 , —SO 2 CF 3 and —SO 2 —C 1-6 -alkyl; R 9 is hydrogen or C 1-6 -alkyl, D is aryl, which may optionally be substituted with one or more substituents selected from halogen, —CF 3 , —OCF 3 , —SCF 3 , —CN, —NO 2 , C 1-10 -alkyl, C 2-6 -alkenyl, C 1-6 -alkoxy, C 1-6 -alkylthio, amino, C 1-6 -alkylamino, di-C 1-6 -alkylamino, —SO 2 CF 3 and —SO 2 —C 1-6 -alkyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl, aryl and aryl-C 1-6 -alkoxy, wherein the non-aromatic and aromatic rings optionally may be substituted with one to three substituents selected from halogen, —CF 3 , —OCF 3 , —SCF 3 , —CN, —NO 2 , C 1-10 -alkyl, C 2-6 -alkenyl, C 1-6 -alkoxy and C 1-6 -alkylthio, or with two substituents on adjacent positions which are combined to form a bridge —O—(CH 2 ) m —O—(CH 2 ) p — or —O—(CF 2 ) m —O—(CF 2 ) p —, wherein m is an integer of from 1 to 6, and p is 0 or 1, or with two substituents on adjacent positions which are combined to form a bridge —O—(CH 2 ) m —O—(CH 2 ) p — or —O—(CF 2 ) n —O—(CF 2 ) p —, wherein m is an integer of from 1 to 6, and p is 0 or 1, or a substituent on B may be combined with a substituent on D to form a —C(═O)— bridge, as well as any diastereomer or enantiomer or tautomeric form or mixtures thereof of these or a pharmaceutically acceptable salt thereof.