Patent ID: 8557824

Claim:
A compound of formula I in which R 1 denotes a fused bicyclic unsaturated or aromatic heterocycle having 1 to 4 N, 0 and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by A, Ar, SR, NR 2 , Hal, NO 2 , CN, (CR 2 ) n [X(CR 2 ) n ] p —Y, CONR 2 , OR 5 and/or ═O (carbonyl oxygen), R 2 , R 3 each, independently of one another, denote H, A, Ar, OR, SR, NR 2 , Hal, NO 2 , CN or (CR 2 ) n [X(CR 2 ) n ] p —Y, R 4 denotes H, Hal, A, OR, NR 2 or (CR 2 ) n [X(CR 2 ) n ] p —Y, X denotes O, NR or CR 2 , Y denotes OR or NR 2 , R 5 denotes H or unbranched or branched alkyl having 1, 2, 3, 4, 5 or 6 C atoms, in which 1-7 H atoms may be replaced by F and/or Cl, K denotes C═O, CR 2 CO or CR 2 , E denotes COOCH 2 , CONHCH 2 or COCH 2 O, R denotes H or unbranched or branched alkyl having 1, 2, 3, 4, 5 or 6 C atoms, W denotes Ar or Het, G denotes CH or N, Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, (CR 2 ) n OR, (CR 2 )NR 2 , SR, NO 2 , CN, COOR, CONR 2 , NRCOA, NRSO 2 A, SO 2 NR 2 , S(O) q A, CO-Het, (CR 2 ) n Het, O(CR 2 ) n -NR 2 , O(CR 2 ) n Het, NHCOOA, NHCONR 2 , NHCOO(CR 2 ) n NR 2 , NHCOO(CR 2 ) n Het, NHCONH(CR 2 ) n NR 2 , NHCONH(CR 2 ) n Het, OCONH(CR 2 ) n NR 2 , OCONH(CR 2 ) n Het, CONR(CR 2 ) n NR 2 , CONR(CR 2 ) n Het and/or COA, Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CR 2 ) n OR, (CR 2 ) n NR 2 , SR, NO 2 , CN, COOR, CONR 2 , NRCOA, NRSO 2 A, SO 2 NR 2 , S(O) q A, CO-Het 1 , (CR 2 ) n Het 1 , O(CR 2 ) n NR 2 , O(CR 2 ) n Het 1 , NHCOOA, NHCONR 2 , NHCOO(CR 2 ) n NR 2 , NHCOO(CR 2 ) n Het 1 , NHCONH(CR 2 ) n NR 2 , NHCONH(CR 2 ) n Het 1 , OCONH(CR 2 ) n NR 2 , OCONH(CR 2 ) n Het 1 , CO-Het 1 , CHO, COA, ═S, ═NH, ═NA and/or ═O (carbonyl oxygen), Het 1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which may be mono- or disubstituted by A, OA, OH, Hal and/or ═O (carbonyl oxygen), A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by OR, CN, NR 2 , F and/or Cl and/or in which one or two non-adjacent CH 2 groups may be replaced by O, NH, S, SO, SO 2 and/or by CH═CH groups, or cyclic alkyl having 3-7 C atoms, m denotes 1, n denotes 1, p denotes 1, q denotes 0, 1 or 2, and Hal denotes F, Cl, Br or I, or a pharmaceutically acceptable salt or tautomer thereof.