Patent ID: 7446112

Claim:
A compound of Formula I, wherein: Ring A is phenyl, pyridine-2-yl, benzodioxol, or benzodioxine; W is nitrogen and each of V, Y and Z is —C(R 5 )—; Each R 1 is independently selected from H, aliphatic, cycloaliphatic, heteroaliphatic and heterocycle, wherein each of the aliphatic, cycloaliphatic, heteroaliphatic and heterocycle is optionally substituted with 1-3 Ra; Each R 2 is independently selected from H, aryl, heteroaryl, aliphatic, cycloaliphatic, heteroaliphatic, heterocycle, —C(O)Rc, and —S(O) 2 Rc, wherein each aliphatic, cycloaliphatic, heteroaliphatic and heterocycle is optionally substituted with 1-3 Ra, and wherein each aryl and heteroaryl is optionally substituted with 1-3 Rb, Each R 3 is independently H, halo, haloaliphatic, aliphatic, —ORd, or —S(O) i Rd; Each R 4 is independently selected from H, halogen, —CN, —OH, —NO 2 , —ORd, —C(O)Rd, —C(O)ORd, —C(O)N(Rd) 2 , —N(Rd) 2 , —N(Rd)C(O)Rd, —N(Rd)C(O)ORd, —OC(O)ORd, —OC(O)NRd, —N(Rd)S(O) 2 Rd, aliphatic optionally substituted with 1-3 Ra, and any two adjacent R 4 on Ring A together with the atoms to which they are attached may be taken together to form a heterocyclic or carbocyclic ring; Each R 5 is independently selected from H, halogen, —CN, —OH, —NO 2 , —ORd, —C(O)Rd, —C(O)ORd, —C(O)N(Rd) 2 , —N(Rd) 2 , —N(Rd)C(O)Rd, —N(Rd)C(O)ORd, —OC(O)ORd, —OC(O)NRd, —N(Rd)S(O) 2 Rd, aliphatic optionally substituted with 1-3 of Ra, and any two adjacent R 5 together with the atoms to which they are attached may be taken together to form a heterocyclic or carbocyclic ring; Each Ra is independently selected from aryl, heteroaryl, halogen, —CN, —OH, —ORd, —C(O)Rd, —C(O)ORd, —C(O)N(Rd) 2 , —N(Rd) 2 , —NRdC(O)Rd, —N(Rd)C(O)ORd, —N(Rd)C(O)N(Rd) 2 , —OC(O)ORd, —OC(O)N(Rd) 2 , ═N—OH, ═NORd, ═N═N(Rd) 2 , ═O, ═S, —S(O) 2 N(Rd) 2 , —N(Rd)S(O) 2 Rd, —N(Rd)S(O) 2 N(Rd) 2 and —S(O) i Rd; Each Rb is independently selected from halo, aryl, —OH, —ORd, —S(O) i Rd, —N(Rd) 2 , —NRdC(O)Rd, —NRdC(O)ORd, —C(O)Rd, —C(O)ORd, —C(O)N(Rd) 2 , —S(O) i N(Rd) 2 , —CN, and —NO 2 ; Each Rc is independently selected from H, aliphatic, cycloaliphatic, heteroaliphatic, heterocycle, aryl, heteroaryl, —ORd, and —N(Rd) 2 , wherein the aliphatic, cycloaliphatic, heteroaliphatic, heterocycle, aryl, and heteroaryl are optionally substituted with 1-3 of Ra; Each Rd is independently selected from H, aliphatic, heteroaliphatic, heterocycle, cycloaliphatic, aryl, heteroaryl, wherein each of aliphatic, heteroaliphatic, heterocycle, cycloaliphatic, aryl, heteroaryl may be optionally substituted with 1-3 of halo, aryl, —OH, —Oaliphatic, —Oaryl, —Oacyl, —NH 2 , —N(aliphatic) 2 , —N(aryl) 2 , —S(O) i aliphatic, or —S(O) i aryl; n is 0 to 3; and i is 0 to 2.