Patent ID: 8729042

Claim:
A method for treating wet age-related macular degeneration, the method comprising administering to a subject in need of such treatment an agent comprising a duplex region directed towards a PPARδ target sequence, the duplex region comprising: a) a sense sequence comprising a nucleic acid sequence identical to or substantially identical to the PPARδ target sequence, wherein the sense strand that is substantially identical to the PPARδ target sequence differs in identity from the PPARδ target sequence by no more than five nucleotides; and b) an anti-sense sequence comprising a nucleic acid sequence complementary to or substantially complementary to the PPARδ target sequence, wherein the antisense strand that is substantially complementary to the PPARδ target sequence differs in complementarity from the PPARδ target sequence by no more than five nucleotides; wherein the method is effective in treating the wet age-related macular degeneration.