Patent ID: 7268164

Claim:
A method of inhibiting epileptogenesis, comprising administering to a subject in need thereof an effective amount of a substituted β-amino anionic compound, comprising an amino group, an anionic group, and a two-carbon spacer unit, wherein said anionic group is a carboxylate; and said amino group is —NR a R b , wherein R a and R b are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, or aryloxycarbonyl; or R a and R b , taken together with the nitrogen to which they are attached, form an unsubstituted or substituted heterocycle having from 3 to 7 atoms in the heterocyclic ring, wherein said amino group and said anionic group are separated by said two-carbon spacer unit; wherein said two-carbon spacer unit may be substituted with a substituent selected from the group consisting of halogen, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylthiocarbonyl, alkoxyl, phosphate, phosphonato, phosphinato, cyano, amino, acylamino, amidino, imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, azido, heterocyclyl, aromatic, and heteroaromatic moieties; or a pharmaceutically acceptable salt or ester thereof, such that epileptogenesis is inhibited.