Patent ID: 8642629

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or ester thereof, wherein: W is C(H) 2 , C(H) 2 —C(H) 2 , C(H)(CH 3 ), CH 2 —C(H)(CH 3 ), or C(H)(CH 3 )—CH 2 ; X is selected from the group consisting of: (1) O, (2) N(H), (3) N(CH 3 ), (4) S, (5) S(O), and (6) S(O) 2 ; Y is carbon or nitrogen; R 1 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) methyl optionally substituted by fluoro, (4) lower alkoxy optionally substituted by fluoro, (5) cyano, and (6) lower alkylsulfonyl; R 2 is hydrogen, fluoro, chloro, lower alkyl, or lower alkoxy; R 3 is hydrogen, fluoro, chloro, bromo, or methyl; R 4 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) lower alkyl optionally substituted by fluoro, (4) lower cycloalkyl, and (5) ethenyl; R 5 and R 6 , independently of each other, are selected from the group consisting of: (1) hydrogen, (2) halogen, (3) lower alkyl, (4) cyano, and (5) lower cycloalkyl; R 7 is cyano or S(O) 2 —R 8 , wherein R 8 is selected from the group consisting of: (1) lower alkyl, (2) lower cycloalkyl, (3) phenyl optionally substituted by (a) halogen, (b) lower alkyl optionally substituted by fluoro, or (c) lower alkoxy, (4) lower alkylamino, (5) lower dialkylamino, (6) lower heterocycloalkyl optionally substituted by halogen, lower alkyl, or lower alkoxycarbonyl, and (7) 2-oxa-6-aza-spiro[3.3]hept-6-yl.