Patent ID: 8420083

Claim:
A method for treating pain, comprising the step of administering to a mammal in need thereof an effective amount of a composition comprising an isolated monoclonal antibody or antigen binding fragment thereof, wherein said said antibody or antigen binding fragment thereof binds an epitope of a human Receptor Advanced Glycation End products (RAGE) molecule, said antibody or antigen binding fragment thereof comprising an antigen binding domain comprising: a) a heavy chain variable domain comprising complementarity determining regions (CDR) 1, 2 and 3 wherein the CDR 1, CDR 2, CDR 3 comprise the sequences of SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12, respectively; and b) a light chain variable domain comprising complementarity determining regions (CDR) 1, 2 and 3 wherein the CDR 1, CDR 2, CDR 3 comprise the sequences of SEQ ID NO: 14, SEQ ID NO: 15, and SEQ ID NO: 16, respectively.