Patent ID: 7226618

Claim:
A stable colloidal suspension comprising submicronic particles, wherein the particles: are individualized supramolecular arrangements; are in a nondissolved state; spontaneously associate with at least one active principle if at least one active principle is added to the colloidal suspension; if loaded with at least one active principle, release the at least one active principle in either or both a prolonged manner or a delayed manner; are stable at a pH of between 4 and 13 in the absence of a surfactant; comprise linear peptide linked amphiphilic polyamino acids (PAA) comprising recurring hydrophilic amino acids (AAI) with ionizable side chains and recurring hydrophobic neutral amino acids (AAO); have a load factor (Ta) with insulin, expressed as % by weight of combined insulin relative to the mass of PAA particles, that is ≧7% and <25%; and have a mean hydrodynamic diameter (Dh), expressed in nm, that is 10 nm≦Dh≦150 nm.