Patent ID: 7183112

Claim:
A kit comprising an anti-malarial compound in combination with a device that effects local administration of said anti-malarial compound, said anti-malarial compound having the formula or pharmaceutically acceptable salts thereof, wherein R 2 and R 3 are indendently hydrogen, or lower alkyl or R 2 and R 3 taken together with the carbon atoms to which they are attached form an aryl ring, which aryl ring is unsubstituted or substituted with an electron withdrawing group or an electron donating group, one of R 1 and R 12 is NHR 13 , while the other is hydrogen; R 4 , R 11 and R 14 are independently hydrogen or an electron donating group or electron withdrawing group; R 5 and R 6 are independently hydrogen or lower alkyl which may be unsubstituted or substituted with an electron withdrawing or electron donating group; R 7 and R 8 are independently hydrogen or lower alkyl, which may be unsubstituted or substituted with an electron withdrawing or electron donating group; Ar is aryl having 6–18 ring carbon atoms which may be unsubstituted or substituted with an electron donating or electron withdrawing group; R 9 is hydrogen or hydroxy or lower alkoxy or R 25 is lower alkyl or hydrogen; n and n 1 are independently 1–6; one of R 18 and R 19 is hydrogen, hydroxy or lower alkyl carbonyloxy and the other is H; R 20 is hydrogen or lower alkoxy and R 21 is hydrogen or CH═CH 2 .