Patent ID: 7115648

Claim:
A compound of formula (1): wherein R 1 is independently selected from C 1-6 alkyl, C 5-7 cycloalkyl, C 5-7 cycloalkylC 1-3 alkyl, C 1-6 alkoxy, C 5-7 cycloalkoxy, C 5-7 cycloalkylC 1-3 alkoxy, heterocyclyl, heterocyclylC 1-3 alkyl, heterocyclyloxy or heterocyclylC 1-3 alkoxy (wherein each of these groups is substituted on carbon with 1, 2, or 3 hydroxy groups, provided that there is no more than one hydroxy group on the same carbon atom and a ring carbon atom adjacent to a ring heteroatom is not substituted by a hydroxy group), and groups of the formula A or A′ wherein x is 0 or 1, r is 0, 1, 2, or 3, s is 1 or 2 and u is 1 or 2; provided that in (A) the hydroxy group is not a substituent on the ring carbon adjacent to the ring oxygen; R 2 is phenyl or heteroaryl (each of which is optionally substituted with 1 or 2 substituents independently selected from halo, cyano, trifluoromethyl, difluoromethyl, fluoromethyl C 1-3 alkoxy, C 1-3 alkanoyl, carbamoyl N—C 1-3 alkylcarbamoyl, N,N-di-C 1-3 alkylcarbamoyl sulfamoyl, N—C 1-3 alkylsulfamoyl, N,N-di-C 1-3 alkylsulfamoyl, and groups of the formulae B and B′ wherein x is 0 or 1, r is 0, 1, 2, or 3, s is 1 or 2 and u is 1 or 2; provided that the hydroxy group is not a substituent on the ring carbon adjacent to the ring oxygen); m is 0, 1, or 2; and R 3 is independently selected from hydrogen or halo; provided that when R 1 is of the formula A or A′, then R 2 does not contain a group of the formula B or B′, and when R 2 is of the formula B or B′, then R 1 does not contain a group of the formula A or A′; or a pharmaceutically acceptable salt or prodrug thereof.