Patent ID: 7966060

Claim:
A method for determining an advanced glycation/glycosylation end product content of non-locally anomalous, intact skin tissue of a human individual, comprising: using a radiation source to irradiate said skin tissue with electromagnetic excitation radiation; receiving and measuring an amount of electromagnetic, fluorescent radiation emitted by said skin tissue in response to said irradiation; and generating, in response to said measured amount of fluorescent radiation, a signal which represents said measured amount of fluorescent radiation; and determining an advanced glycation/glycosylation end product content of said skin tissue from said signal, and outputting said determined advanced glycation/glycosylation end product content; wherein said skin tissue is non-locally anomalous, intact skin tissue in vivo which is irradiated noninvasively and simultaneously in its entirety by directing said radiation from said radiation source to a portion of the outer surface of the skin, wherein fluorescent radiation emitted in response to said irradiation is simultaneously received from a surface area of the irradiated portions of the skin surface of at least 1 cm 2 , wherein said fluorescent radiation is received via a measuring window; and wherein said measuring window is oriented at an angle of 25-65° relative to the irradiated portion of the surface of the skin.