Patent ID: 8604193

Claim:
A method of preparing a compound of Formula (I), which comprises subjecting a compound of Formula (IV) to a reaction with a compound of Formula (V): wherein, R 1 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclyl, substituted carbocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, or substituted heteroarylalkyl; R 3 is H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclyl, substituted carbocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl or —CHR 7 R 8 , R 7 and R 8 being each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclyl, substituted carbocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, or substituted heteroarylalkyl; M is MgX 1 or Li, X 1 being halogen; and Y is selected from the group consisting of halogen, cyano, imidazol-1-yl, pyrazol-1-yl, —O—C(O)R 2 or —O—C(O)OR 4 , R 2 being H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclyl, substituted carbocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, or substituted heteroarylalkyl, and R 4 being alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, carbocyclyl, substituted carbocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, or substituted heteroarylalkyl.