Patent ID: 8445482

Claim:
A chemical entity selected from the group consisting of compounds of Formula (I) and pharmaceutically acceptable salts of compounds of Formula (I); wherein X is S; R 1 and R 2 taken together form —(CH 2 ) 4-5 — optionally substituted with one or two substituents independently selected from C 1-4 alkyl, C 1-4 alkoxy, CF 3 , and fluoro; —N(R 3 )R 4 is one of the following moieties, wherein R 3 and R 4 are taken together or separately as defined by each one of said moieties: where q is 0 or 1; p is 0 or 1; r is 0 or 1; R a is H or OH; R b and R c are each independently H or C 1-3 alkyl; R d is H or a C 1-3 alkyl group unsubstituted or substituted with OH or NH 2 ; R e and R f are each methyl, or R e and R f taken together form a methylene or ethylene bridge; and R 5 is H or NH 2 .