Patent ID: 6989448

Claim:
Compounds having the Formula I wherein * denotes a first chiral center when R 3 and R 4 are different; @ denotes a second chiral center; R 1 and R 2 are independently hydrogen, C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl C 1 -C 8 substituted alkyl, C 1 -C 6 alkoxy, hydroxy, C 3 -C 7 cycloalkenyl, C 3 -C 7 substituted cycloalkenyl, C 3 -C 7 substituted cycloalkyl, —(CH 2 ) n -aryl, —(CH 2 ) n -substituted aryl, C 2 -C 8 alkenyl, C 2 -C 8 substituted alkenyl, —(CH 2 ) n -heteroaryl, —(CH 2 ) n —C 3 -C 7 cycloalkyl, —(CH 2 ) n -substituted heteroaryl, —(CH 2 ) n —C 3 -C 7 heterocycloalkyl, —(CH 2 ) n -substituted C 3 -C 7 heterocycloalkyl, or R 1 and R 2 may be taken together to form a 5- to 7-membered ring which may contain a heteroatom, provided that R 1 and R 2 are not both hydrogen; R 3 , R 5 , and R 6 are independently hydrogen or C 1 -C 8 alkyl; R 4 is —(CH 2 ) n -heteroaryl or —(CH 2 ) n -substituted heteroaryl; Y is —(CH 2 ) n —, O(CH 2 ) n —, —(CH 2 ) n O—, —N(R 7 )(CH 2 ) n —, —(CH 2 ) n N(R 7 )—, —S(CH 2 ) n —, —(CH 2 ) n S—, —C═C—, or —C≡C—; R 7 is hydrogen, methyl or ethyl; Z is aryl, substituted aryl, heteroaryl, substituted heteroaryl, C 3 -C 7 cycloalkyl, substituted C 3 -C 7 cycloalkyl, C 1 -C 8 alkyl, —C 3 -C 7 heterocycle, or -substituted C 3 -C 7 heterocycle; X is OR 8 , NHR 8 , or NR 8 R 9 ; R 8 and R 9 are independently C 1 -C 12 alkyl, C 1 -C 12 substituted alkyl, —(CH 2 ) n —C 3 -C 8 heterocycloalkyl, C 3 -C 7 cycloalkyl, substituted C 3 -C 7 cycloalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, or NR 8 R 9 can together with the nitrogen atom form a ring having from 4 to 7 atoms; each n is 0 to 5, and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.