Patent ID: 7666583

Claim:
A method for diagnosing or aiding in the diagnosis of ovarian cancer in a subject comprising; (a) measuring the expression levels of four or more biomarkers in a sample from a subject, wherein four of the biomarkers are prolactin, osteopontin (OPN), leptin, and insulin-like growth factor II (IGF-II); (b) comparing the expression level of prolactin, OPN, leptin, and IGF-II to a predetermined standard for prolactin, OPN, leptin, and IGF-II, respectively, wherein a significant difference in the expression level of two or more of the prolactin, OPN, leptin, and IGF-II biomarkers in the sample as compared to a predetermined standard for each of the prolactin, OPN, leptin, and IGF-II biomarkers diagnoses or aids in the diagnosis of ovarian cancer, and wherein a significant difference in the expression level for prolactin or OPN is an increase in the expression level of prolactin or OPN compared to the predetermined standards for prolactin and OPN, respectively; and a significant difference in the expression level for leptin or IGF-II is a decrease in the level of expression of leptin or IGF-II compared to the predetermined standards for leptin and IGF-II, respectively.