Patent ID: 8710000

Claim:
An insulin derivative having a formula wherein Ins is a parent insulin moiety and Q 1 -Q 2 -[CH 2 ] n —X 1 —[CH 2 ] n -Q 3 -[CH 2 ] n —X 2 —[CH 2 ] n -Q 4 -[CH 2 ] n —X 3 —[CH 2 ] n -Q 5 -[CH 2 ] n —Z is a substituent and where the Ins is attached to the substituent via an amide bond between the α-amino group of the N-terminal amino acid residue of the B chain of Ins or an ε-amino group of a Lys residue present in the A or B chain of Ins and a CO group in Q 1 or Q 2 of the substituent; Q 1 is selected from the group consisting of: an amino acid residue, which residue forms, with its carboxylic acid group, an amide group together with the α-amino group of the N-terminal amino acid residue of the B chain of Ins or together with the ε-amino group of a Lys residue present in the A or B chain of Ins, a chain composed of two, three or four α-amino acid residues as specified above linked together via amide bonds, which chain is linked via an amide bond to the α-amino group of the N-terminal amino acid residue of the B chain of Ins or to the ε-amino group of a Lys residue present in the A or B chain of Ins, and a bond Q 2 is selected from the group consisting of: —CO—(CH 2 ) 2 —NH—(CH 2 ) 2 —, —CO—CH 2 —NH—CH 2 —, —CO—(CH 2 ) p —NR 1 —(CH 2 ) p′ —, and where n′=1-6, where R 1 and R 2 , independently of each other can be H, —CH 3 or —(CH 2 ) 1-6 —CH 3 , and where p and p′ independently of each other can be 1-6; Q 3 is —(CH 2 ) m — where m is an integer in the range of 6 to 32; X 1 is selected from the group consisting of: O, —C═O, and NCOR 1 , where R 1 can be H, —CH 3 or —(CH 2 ) 1-6 —CH 3 , and where R is hydrogen, C 1-3 -alkyl, C 2-3 -alkenyl or C 2-3 -alkynyl; Q 4 , Q 5 , X 2 and X 3 are bonds and all n are zero; and Z is —COOH and any Zn 2+ complex thereof.