Patent ID: 8741900

Claim:
A method of treating Alzheimer's disease comprising administering to a subject in need thereof a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein W is CR 6 , and X and Y are N, and R 6 is —H, R 1 , R 2 , R 4 , and R 5 are —H, R 3 is the group —X 1 -L 1 -R 13 wherein X 1 is selected from the group consisting of a direct bond and —O—, L 1 is selected from the group consisting of a direct bond, —CH 2 —, and —CH 2 CH 2 —, and R 13 is selected from the group consisting of -phenyl and -cyclohexyl, wherein the cyclohexyl and phenyl groups of R 13 are optionally substituted one or more times with R 14 , wherein each R 14 is independently selected from the group consisting of -halogen, —(C 1 -C 6 )alkyl, and —(C 1 -C 6 )haloalkyl, R 7 is the group -L 2 -X 2 —R 15 wherein L 2 is —(C 1 -C 4 )alkylene-, X 2 is selected from the group consisting of a direct bond and —O—, and R 15 is selected from the group consisting of —(C 1 -C 4 )alkyl, optionally substituted one or more times with R 16 , wherein each R 16 is independently selected from the group consisting of -halogen, R 8 is the group —X 3 -L 3 -R 17 , wherein X 3 is selected from the group consisting of direct bond, —O—, and —C(O)NH—, L 3 is selected from the group consisting of a direct bond and —CH 2 —, R 17 is wherein each R 22 may be attached to any of the ring carbon atoms of R 17 , and wherein each R 22 is independently selected from the group consisting of -halogen, X 4 —R 24 , —(C 1 -C 6 )alkylene-R 24 , —(C 1 -C 6 )alkylene-X 5 —R 24 , and —X 4 —(C 1 -C 6 )alkylene-NR 25 R 26 , wherein X 4 and X 5 are independently selected from the group consisting of: direct bond, —O—, and —N(R 27 )—, wherein R 27 is selected from the group consisting of —H and —(C 1 -C 6 )alkyl, R 24 is selected from the group consisting of —H, and —(C 1 -C 6 )alkyl, wherein the alkyl groups of R 24 is optionally substituted one or more times with R 28 , wherein each R 28 is independently selected from the group consisting of halogen, R 25 and R 26 are independently selected from the group consisting of —H, and —(C 1 -C 6 )alkyl, R 23 is selected from the group consisting of —H and —(C 1 -C 6 )alkyl, and n is 0, 1, 2, or 3.