Patent ID: 8518961

Claim:
A spontaneously dispersible pharmaceutical composition comprising about 0.05 to about 20% by weight of 7-t-butoxyiminomethylcamptothecin and a carrier medium comprising about 5 to about 85% by weight of a lipophilic component selected from the group consisting of C 8 -C 10 fatty acid monoglycerides and diglycerides, a refined glycerol-transesterified corn oil, triethylcitrate, and castor oil; about 5 to about 90% by weight of a surfactant component selected from the group consisting of polyethylene-hydrogenated castor oil and Vitamin E TPGS; about 5 to about 60% by weight of a hydrophilic component selected from the group consisting of propylene glycol, PEG400 and ethylacetate; and about 5 to 20% of ethanol by weight as a co-solvent, all weights based on the total composition, wherein the spontaneously dispersible pharmaceutical composition is a microemulsion preconcentrate.