Patent ID: 8080543

Claim:
A compound of formula I, or a pharmaceutically acceptable salt, or an optical isomer thereof, wherein: A is selected from the group consisting of 1) an aryl ring, and 2) a 6-membered unsaturated monocyclic heteroaryl ring with 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S, wherein the point of attachment to the heteroaryl ring is a carbon atom, wherein said aryl or heteroaryl ring is unsubstituted, mono-substituted with R 1 , disubstituted with groups independently selected from R 1 , trisubstituted with groups independently selected from R 1 , or tetrasubstituted with groups independently selected from R 1 , and wherein any stable S or N heteroaryl or heterocyclic ring atom is unsubstituted or substituted with oxo; D is selected from the group consisting of 1) a saturated 4-6 membered heterocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms independently selected from the group consisting of N, O or S, wherein the point of attachment to the heterocyclic ring is a nitrogen atom, wherein said heterocyclic ring is unsubstituted, monosubstituted with R 2 or di-substituted with groups independently selected from R 2 , 2)—NH(CH 2 ) n CH 3 , and 3) —NH(CH 2 ) n CF 3 ; R 1 is independently selected from the group consisting of halogen and CN; R 2 is independently selected from the group consisting of halogen; R 4 is independently selected from the group consisting of hydrogen, halogen and CF 3 ; R 5 is independently selected from the group consisting of hydrogen, halogen, CF 3 , OCF 3 , and C 1-6 alkyl; and n is 1, 2, 3, 4, 5, or 6.