Patent ID: 7335722

Claim:
A process for the preparation of peptides having angiotensin converting enzyme inhibitory activity, which comprises the following steps: (a) adding NEUTRASE, a protein hydrolasea, to chicken bones in a liquid to hydrolyze the chicken bones at 62° C. for 2 hours; (b) re-hydrolyzing the hydrolyzate of step (a) with ALCALASE a protein hydrolase, at 65° C. for 2.5 hours; (c) separating the resulting hydrolyzed chicken bones residues and liquid after step (b) by a process selected from the group consisting of press filtration and ultrafiltration employing a membrane with a molecular weight cut off of 10,000, and then concentrating the separated liquid by drying; and (d) purifying peptides having angiotensin converting enzyme inhibitory activity from the dried product obtained from step (c), wherein the peptides have the sequence selected from the group consisting of VLY, VLPP (SEQ ID NO: 1), and ILPP (SEQ ID NO: 2).