Patent ID: 8614346

Claim:
A method of preparing an acyl-amphetamine compound of Formula III, comprising: (a) admixing an acyl-halamphetamine compound of Formula I, a hydrogenation catalyst, and hydrogen gas to provide an acyl-amphetamine compound of Formula II; which acyl-amphetamine compound of Formula II is admixed with a deprotecting agent to provide an acyl-amphetamine compound of Formula III; or (b) admixing an acyl-halamphetamine compound of Formula I and a deprotecting agent to provide an acyl-halamphetamine compound of Formula IIa; which acyl-halamphetamine compound of Formula IIa is admixed with a hydrogenation catalyst and hydrogen gas to provide an acyl-amphetamine compound of Formula III; wherein the acyl-halamphetamine compound of Formula I is represented by: wherein: R 1 is hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; R 2 represents independently for each occurrence hydrogen or C 1 -C 6 alkyl; R 3 represents independently for each occurrence C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, or aryl; and X is Cl, Br, or I; wherein the acyl-amphetamine compound of Formula II is represented by: wherein: R 1 is hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; R 2 represents independently for each occurrence hydrogen or C 1 -C 6 alkyl; and R 3 represents independently for each occurrence C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, or aryl; wherein the acyl-halamphetamine compound of Formula IIa is represented by: wherein: R 1 is hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; R 2 represents independently for each occurrence hydrogen or C 1 -C 6 alkyl; and X is Cl, Br, or I; and the acyl-amphetamine compound of Formula III is represented by: wherein: R 1 is hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; and R 2 represents independently for each occurrence hydrogen or C 1 -C 6 alkyl.