Patent ID: 8906940

Claim:
A pharmaceutical formulation in a compressed tablet oral dosage form consisting essentially of: (a) about 10 mgs to about 100 mgs of a proton pump inhibitor, wherein the proton pump inhibitor is omeprazole; (b) at least one antacid, wherein the antacid comprises about 400 mgs to about 1400 mgs of NaHCO 3 ; (c) about 2 wt-% to about 8 wt-% of a disintegrant; (d) about 3 wt-% to about 8 wt-% of a binder; and (e) about 0.5 wt-% to about 3 wt-% of a lubricant; wherein the antacid further comprises magnesium hydroxide and the total amount of antacid present in the tablet is about 10 mEg to about 30 mEg; wherein the tablet is a homogeneous blend of omeprazole, antacids, disintegrant, binder, and lubricant; and wherein upon oral administration of the compressed tablet to a fasted human subject, a T max of the proton pump inhibitor is obtained within about 45 minutes after administration on day I, and an initial serum concentration of the proton pump inhibitor is greater than 300 ng/ml within 45 minutes after administration; and wherein the compressed tablet has a hardness of between is kPa and 20 kPa.