Patent ID: 8008469

Claim:
An antisense conjugate for use in inducing immunologic tolerance in a subject, comprising (a) a substantially uncharged antisense oligonucleotide compound (i) composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an, adjacent subunit, and containing 20-25 subunits, (ii) comprising the base sequence identified by SEQ ID NO: 17, (iii) effective, when hybridized to the processed human cFLIP transcript, to block expression of cFLIP in lymphocytes, and (b) covalently coupled to the antisense oligonucleotide compound, an arginine-rich peptide effective to enhance the uptake of the antisense compound into lymphocytes.