Patent ID: 8119636

Claim:
A compound of Formula I R is R 1 , R 2 , R 3 , or R 4 ; R 1 is lower alkyl, phenyl, benzyl, heteroaryl, cycloalkyl, heterocycloalkyl, or cycloalkylalkyl, optionally substituted with one or more R 1a ; R 1a is R 1b or R 1c ; R 1b is halogen, oxo, hydroxy, or —CN; R 1c is —C(═O)O(R 1f ), —C(═O)(CH 2 ) m (R 1e ), —S(R 1f ), —S(O) 2 (R 1f ), or —S(═O)(R 1f ), lower alkyl, lower alkoxy, amino, amido, lower haloalkyl, phenyl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkyloxy, or heterocycloalkyloxy optionally substituted with one or more R 1d ; R 1d is H, halogen, hydroxy, lower alkyl, lower alkoxy, or lower haloalkyl; R 1e is H, lower alkyl, lower alkoxy, cyano, lower haloalkyl, phenyl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 1f is H, lower alkyl, lower haloalkyl, phenyl, heteroaryl, cycloalkyl, or heterocycloalkyl; m is 0, 1, or 2; R 2 is N(R 2a ) 2 ; each R 2a is independently H or R 2b ; each R 2b is independently lower alkyl, phenyl, heteroaryl, cycloalkyl, heterocycloalkyl, or heterocycloalkyl alkylene, optionally substituted with one or more R 2c ; R 2c is R 2d or R 2e ; R 2d is halogen, oxo, or hydroxy; R 2e is —N(R 2g ) 2 , —C(═O)(R 2g ), —C(═O)O(R 2g ), —C(═O)N(R 2g ) 2 , —N(R 2g )C(═O)(R 2g ), —S(═O) 2 (R 2g ), —S(O) 2 N(R 2g ) 2 , lower alkyl, lower alkoxy, lower haloalkyl, phenyl, heteroaryl, heteroaryloxy, cycloalkyl, or heterocycloalkyl, optionally substituted with one or more R 2f ; each R 2f is independently H, halogen, lower alkyl, lower alkoxy, lower haloalkyl; each R 2g is independently H, lower alkyl, lower alkoxy, lower haloalkyl, or phenyl; R 3 is —C(═O)R 3a ; R 3a is lower alkyl, lower alkoxy, phenyl, or N(R 3b ) 2 ; each R 3b is independently H or lower alkyl; R 4 is —O(R 4a ); R 4a is H or R 4b ; R 4b is phenyl, benzyl, lower haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, optionally substituted with one or more R 4c ; R 4c is halogen, hydroxy, lower alkyl, lower haloalkyl, or lower alkoxy; Q 4 is Q 4a or Q 4b ; Q 4a is H or halogen; Q 4b is lower alkyl, lower alkenyl, lower alkynyl, or lower haloalkyl with the proviso that when R is R 4 , R 4 is —O(R 4a ), R 4a is H, and Q 4 is Q 4a , then Q 4a is not H; or a pharmaceutically acceptable salt thereof.