Patent ID: 7615547

Claim:
A process for preparing a liquid suspension which is stable at the time of use, which process comprises: a) dispersing a liposoluble and hydrophobic substance having a water-solubility at 20° C. of less than 20 μg/ml in a medium consisting of water and a surfactant to create an aqueous dispersion, wherein the liposoluble and hydrophobic substance is a steroidal substance and wherein the dispersion is effected at a temperature of from 20° C. to 60° C.; b) incorporating a water-soluble polyhydroxylated solid excipient in the aqueous dispersion and therein obtaining a granulable pasty mass; c) granulating the pasty mass; and d) placing the thus-obtained granulate in an aqueous medium; wherein the amount of surfactant, by weight, relative to the amount of liposoluble and hydrophobic substance, is from 0.013 to 0.7; wherein the amount of water, by weight, relative to the amount of liposoluble and hydrophobic substance, is from 0.2 to 1; and wherein the amount of polyhydroxylated solid excipient, by weight, relative to the amount of liposoluble and hydrophobic substance, is from 1 to 6.