Patent ID: 7628990

Claim:
A method of modulating an immune response in an individual, comprising administering to the individual a population of conjugate molecules in a pharmaceutically acceptable excipient, wherein the population is in an amount sufficient to modulate the immune response, wherein the conjugate molecules comprise an allergen and a polynucleotide comprising an immunostimulatory sequence (ISS), wherein the ISS comprises a 5′-cytosine guanine-3′ dinucleotide, wherein the polynucleotide is greater than 8 and less than about 200 nucleotides in length, wherein the extent of conjugation in the population provides an average of at least 5.5 ISS-containing polynucleotides per allergen molecule, and wherein modulating the immune response stimulates production of a Th1-associated cytokine, stimulates Th1 lymphocytes, reduces production of a Th2-associated cytokine, suppresses Th2 lymphocytes, suppresses production of allergen-specific antibodies, reduces allergen-stimulated IgE production, treats an allergic condition, or treats an IgE-related disorder.