Patent ID: 7259161

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W 1 is nitrogen or CH, W 2 is nitrogen or C—(J) p R U , and W 3 is nitrogen or C—(V) q R V ; p and q are each independently 0 or 1; R U and R V are each independently R or Ar 1 ; U and V are each independently a bond or a C 1-6 alkylidene chain, wherein up to two methylene units of the chain are optionally and independently replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; each occurrence of R is independently hydrogen or an optionally substituted C 1 –C 4 aliphatic, or two R bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3–7 membered saturated, partially unsaturated, or fully unsaturated ring having 0–2 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur; Ar 1 is a 5–7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0–3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8–12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0–5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein Ar 1 is optionally substituted with m independent occurrences of Z—R 5 ; wherein m is 0–5, Z is a bond or is a C 1 –C 6 alkylidene chain wherein up to two methylene units of Z are optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each occurrence of R 5 is independently hydrogen, an optionally substituted aliphatic, heteroaliphatic, aryl or heteroaryl group, halogen, NO 2 , CN, OR, SR, N(R) 2 , NRCOR, NRCON(R) 2 , NRCO 2 R, COR, CO 2 R, OCOR, CON(R) 2 , OCON(R) 2 , SOR, SO 2 R, SO 2 N(R) 2 , NRSO 2 R, NRSO 2 N(R) 2 , COCOR, or COCH 2 COR; R 1 and R 2 are taken together and fused to ring B to form a heterocyclic moiety selected from one of formulae (a) through (f): wherein each occurrence of R X is independently hydrogen, QR, or Q n Ar 1 ; n is zero or one; and Q is an optionally substituted C 1-4 alkylidene chain, wherein one methylene unit of Q is optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; R 3 is hydrogen, halogen, QR, Q n CN, Q n NO 2 , or Q n Ar 1 ; and R 4 is Ar 1 , or T—Ar 1 ; wherein T is a C 1-2 alkylidene chain wherein one methylene wilt of T is optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR.