Patent ID: 8821935

Claim:
A microcapsule for the modified release of at least one active principle with low water solubility, wherein the microcapsule comprises a core comprising at least one active principle, wherein at least one of the at least one active principle has low solubility, and a coating film applied onto the core, wherein the mean diameter of the microcapsule is less than 1000 microns, wherein the coating film is at least 3% dry weight to total weight, and comprises: I. at least one film-forming polymer selected from the group consisting of: acrylic derivatives, poly (vinyl acetate), water-insoluble derivatives of cellulose, and mixtures thereof, wherein the polymer is insoluble in gastrointestinal tract fluid; II. at least one water-soluble polymer selected from the group consisting of: water-soluble derivatives of cellulose, polyvinyl alcohols (PVAs), polyoxyethylenes (POEs), polyvinylpyrrolidones (PVPs), and mixtures thereof; and III. at least one plasticizer, wherein the at least one film-forming polymer insoluble in gastrointestinal tract fluid is between 50-80% dry weight relative to the total mass of the coating; wherein the mass fraction of the at least one water-soluble polymer dry weight, relative to the total dry weight of the at least one film-forming polymer insoluble in gastrointestinal tract fluids and of the at least one water-soluble polymer, is between 15 and 60%; and wherein the mass fraction of the at least one plasticizer dry weight, relative to the total dry weight of the at least one film-forming polymer insoluble in gastrointestinal tract fluids and the at least one plasticizer, is between 1 and 30%; wherein the coating film does not comprise the following combination of components: at least one film-forming polymer insoluble in gastrointestinal tract fluid, present in a proportion of 50 to 90% by weight on a dry basis relative to the total mass of the coating composition, and consisting of water-insoluble derivatives of cellulose; at least one nitrogenous polymer, present in a proportion of 2 to 25% by weight on a dry basis relative to the total mass of the coating composition, and consisting of; polyacrylamide, poly-N-vinyl-amide, poly-(N-vinyllactam), and mixtures thereof; at least one plasticizer, present in a proportion of 2 to 20% by weight on a dry basis relative to the total mass of the coating composition, and consisting of: glyceryl esters, phthalates, citrates, sebacates, cetyl alcohol esters, castor oil, salicylic acid, cutin, and mixtures thereof; and at least one surfactant or lubricant, present in a proportion of 2 to 20% by weight on a dry basis relative to the total mass of the coating composition, and consisting of: anionic surfactants, nonionic surfactants, lubricants, and mixtures thereof.