Patent ID: 7897592

Claim:
A compound of Formula I where: R 1 is (Ar 1 )alkyl, (Ar 1 )(CON(R 8 )(R 9 ))alkyl, (Ar 1 )(CO 2 R 14 )alkyl, (Ar 1 )hydroxyalkyl, or (Ar 1 )oxyalkyl; R 2 is hydrogen, alkyl, hydroxy, or alkoxy; R 3 is hydrogen, halo, hydroxy, cyano, alkyl, cycloalkyl, C 5-7 cycloalkenyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, N(R 8 )(R 9 ), NHAr 2 , N(R 6 )SO 2 R 7 , N(R 6 )COR 7 , N(R 6 )CO 2 R 7 , OCOR 7 , OCO 2 R 7 , OCON(R 8 )(R 9 ), OCH 2 CO 2 R 7 , OCH 2 CON(R 8 )(R 9 ), COR 6 , CO 2 R 6 , CON(R 8 )(R 9 ), SOR 7 , S(═NR 7 ), SO 2 R 7 , SO 2 N(R 6 )(R 6 ), PO(OR 6 ) 2 , C 2-4 (R 12 )alkynyl, R 13 , Ar 2 , or Ar 3 ; R 4 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, haloalkoxy, or N(R 6 )(R 6 ); R 5 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, haloalkoxy, or N(R 6 )(R 6 ); R 6 is hydrogen, alkyl, or cycloalkyl; R 7 is alkyl or cycloalkyl; R 8 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl or dialkylaminoalkyl; R 9 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl or dialkylaminoalkyl; or N(R 8 )(R 9 ) taken together is azetidinyl, pyrrolidinyl, (R 10 )-piperidinyl, N—(R 11 )-piperazinyl, morpholinyl, thiomorpholinyl, or dioxothiazinyl; R 10 is hydrogen, alkyl, or hydroxyalkyl; R 11 is hydrogen, alkyl, cycloalkyl, COR 6 , or CO 2 R 6 ; R 12 is hydrogen, hydroxy, N(R 6 )(R 6 ), SO 2 R 7 , OSO 2 R 7 , or dioxothiazinyl; R 13 is azetidinonyl, pyrrolidinonyl, valerolactamyl, caprolactamyl, maleimido, oxazolidonyl, or dioxothiazinyl, and is substituted with 0-2 substituents selected from the group consisting of alkyl, hydroxyalkyl, acetoxyalkyl, and aminoalkyl; R 14 is hydrogen or alkyl; Ar 2 is tetrazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, furanyl, thienyl, pyrrolyl, pyrimidinyl, pyrazinyl, pyridinyl, hydroxypyridinyl, quinolinyl, isoquinolinyl, or indolyl, and is substituted with 0-2 substituents selected from the group consisting of halo, cyano, benzyl, alkyl, alkoxy, N(R 8 )(R 9 ), CON(R 8 )(R 9 ), CO 2 R 6 , CONHSO 2 N(R 6 )(R 6 ), CONHSO 2 N(R 6 )(phenyl), and CONHSO 2 N(R 6 )(halophenyl); Ar 3 is phenyl substituted with 0-2 substituents selected from the group consisting of halo, cyano, hydroxy, alkyl, alkoxy, alkoxyalkyl, haloalkyl, haloalkoxy, N(R 8 )(R 9 ), CON(R 6 )(R 6 ), and CH 2 N(R 8 )(R 9 ), or is dioxolanylphenyl; and X-Y-Z is C(R 14 ) 2 SC(R 14 ) 2 C(R 14 ) 2 , C(R 14 ) 2 SOC(R 14 ) 2 C(R 14 ) 2 , or C(R 14 ) 2 SO 2 C(R 14 ) 2 C(R 14 ) 2 ; or a pharmaceutically acceptable salt thereof.