Patent ID: 7795223

Claim:
A method of treatment of inflammatory airway or lung disease, comprising the step of administering an effective amount of a peptide which has the ability to inhibit one or more functions of the T cell receptor (TCR) to a subject in need of such treatment, in which the peptide has a sequence selected from the grow consisting of: (SEQ. ID. NO. 1) NH 2 -Gly-Leu-Arg-Ile-Leu-Leu-Leu-Lys-Val-OH; (SEQ. ID. NO. 2) NH 2 -Leu-Lys-Ile-Leu-Leu-Leu-Arg-Val-OH; (SEQ. ID. NO. 3) NH 2 -Gly-Phe-Arg-Ile-Leu-Leu-Leu-Lys-Val-OH; (SEQ. ID. NO. 4) NH 2 -Val-Phe-Arg-Ile-Leu-Leu-Leu-Lys-Val-OH; (SEQ. ID. NO. 5) NH 2 -Phe-Lys-Ile-Leu-Leu-Leu-Arg-Val-OH; (SEQ. ID. NO. 6) NH 2 -Ala-Arg-Leu-Pro-Val-Leu-Lys-Leu-Val-OH; (SEQ. ID. NO. 7) NH 2 -Arg-Val-Met-Ala-Pro-Arg-Ala-Leu-Leu-OH; (SEQ. ID. NO. 8) NH 2 -Val-Lys-Leu-Phe-Pro-Val-Lys-Leu-Phe-Pro-OH; (SEQ. ID. NO. 9) NH 2 -Leu-Arg-Ile-Leu-Leu-Leu-Ile-Lys-Val-OH; (SEQ. ID. NO. 10) NH 2 -Leu-Arg-Leu-Leu-Leu-Lys-Val-OH. (SEQ. ID. NO. 11) NH 2 -Met-Gly-Leu-Arg-Ile-Leu-Leu-Leu-OH; (SEQ. ID. NO. 12) NH 2 -Leu-Asp-Ile-Leu-Leu-Leu-Glu-Val-OH; (SEQ. ID. NO. 13) NH 2 -Ile-Leu-Leu-Leu-Lys-Val-Ala-Gly-Phe-OH; (SEQ. ID. NO. 14) NH 2 -Ile-Leu-Leu-Leu-Lys-Val-Ala-Gly-OH; (SEQ. ID. NO. 15) NH 2 -Leu-Arg-Ile-Leu-Leu-Leu-Gly-Val-OH; (SEQ. ID. NO. 16) NH 2 -Leu-Gly-Ile-Leu-Leu-Leu-Lys-Val-OH; (SEQ. ID. NO. 17) NH 2 -Ile-Leu-Leu-Gly-Lys-Ala-Thr-Leu-Tyr-OH; (SEQ. ID. NO. 18) NH 2 -Leu-Leu-Met-Thr-Leu-Arg-Leu-Trp-Ser-Ser-OH; (SEQ. ID. NO. 19) NH 2 -Ile-Ile-Val-Thr-Asp-Val-Ile-Ala-Thr-Leu-OH; (SEQ. ID. NO. 20) NH 2 -Ile-Val-Ile-Val-Asp-Ile-Cys-Ile-Thr-OH; (SEQ. ID. NO. 21) NH 2 -Phe-Leu-Phe-Ala-Glu-Ile-Val-Ser-Ile-OH; (SEQ. ID. NO. 22) NH 2 -Tyr-Gly-Arg-Ala-Asp-Cys-Gly-Ile-Thr-Ser-OH; (SEQ. ID. NO. 23) NH 2 -Trp-Gly-Arg-Ala-Asp-Cys-Gly-Ile-Thr-Ser-OH; (SEQ. ID. NO. 24) NH 2 -Tyr-Gly-Arg-Ala-Asp-Cys-Ile-Thr-Ser-OH; and (SEQ. ID. NO. 25) NH 2 -Ser-Ser-Asp-Val-Pro-Cys-Asp-Ala-Thr-Leu-Thr- OH; wherein the C-terminus of said peptide is conjugated to a lipid moiety selected from: N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]cysteine (Pam3Cys), or an analogue thereof in which only two acyl substituents are present.