Patent ID: 6881379

Claim:
Method of fabricating a detection system for detecting various analytes in one sample or for detecting one analyte in a multiplicity of samples, comprising a planar or essentially planar substrate surface and, arranged on said surface, arrays of analyte-binding capturing molecules, characterized by the following steps: (a) providing a planar or essentially planar substrate with more than one sensor for the chemical, optical or electrical detection of the analytes which are arranged directly on or in the surface of the substrate, (b) applying a layer to the substrate, said layer being either already micropatterned or applying a continuous layer to the substrate and micropatterning the layer, in each case in such a way that disjunct regions of the substrate, on or in whose surface sensors are arranged, are not covered by the layer, where layer and substrate are sealingly joined to one another at least around the uncovered regions, (c) bringing at least part of the uncovered regions into contact with at least one liquid which contains capturing molecules, in such a way that the capturing molecules are capable of adhering to the substrate surface and/or to the surface of the sensors or to bind thereto, (d) removing the non-adhering constituents of the liquid, (e) removing the micropatterned layer or parts of said layer.