Patent ID: 7109223

Claim:
A compound having the structural formula I: or a pharmaceutically acceptable salt thereof, wherein, X is S; Y 1 is 1) CH 2 CH 2 , or 2) CHCH; Y is C(O) or CH(OH); A and W are independently selected from the group consisting of 1) a bond, and 2) C 1-6 alkylene, unsubstituted or substituted with 1, 2, 3, or 4 halogen atoms; Z is 4) CH 2 , 5) HC═CH, or 6) C≡C; R 1 is COR 5 , OH, (CH 2 ) 1-3 CO 2 R 6 , (CH 2 ) 0-4 SO 3 R 6 , CF 2 SO 2 NH 2 , SO 2 NH 2 , SO 2 NHCOR 8 , PO(OH) 2 , C 1-4 alkoxy, hydroxymethylketone, (CH 2 ) 0-4 heterocyclyl, wherein heterocyclyl is unsubstituted or substituted with 1 to 3 groups of R 8 , or tetrazole; R 2 is 1) C 1-6 alkyl, provided that R 2 is not n-pentyl or butyl, 2) (CH 2 ) 0-8 C 6-10 aryl, 3) (CH 2 ) 0-8 C 5-10 heteroaryl, 4) (CH 2 ) 0-8 C 3-10 heterocycloalkyl, 5) (CH 2 ) 0-8 C 3-8 cycloalkyl, 6) O—C 1-10 alkyl, 7) O—C 6-10 alkyl, 8) O—C 5-10 heteroaryl, 9) O—C 5-10 heterocycloalkyl, or 10) O—C 3-10 cycloalkyl, wherein aryl, heteroaryl, heterocycloalkyl, and cycloalkyl are unsubstituted or substituted with 1–3 groups of R b ; R 3 and R 4 are independently selected from the group consisting of 1) hydrogen, 2) halogen, and 3) C 1-6 alkyl, or R 3 and R 4 , together with the carbon atom to which they are attached, form a C 3-7 cycloalkyl ring; R 5 is 1) hydrogen, 2) OH, 3) CH 2 OH, 4) C 1-6 alkoxy, 5) NHPO 2 R 6 , 6) NHR 9 , 7) NHSO 2 R 8 , or 8) NR 6 R 7 ; R 6 and R 7 are independently selected from the group consisting of hydrogen and C 1-6 alkyl; R 8 is selected from the group consisting of hydrogen, C 6-10 aryl, and C 1-4 alkyl; R 9 is acyl or sulfonyl; and R a and R b are independently selected from the group consisting of 1) C 1-6 alkoxy, 2) C 1-6 alkyl, unsubstituted or substituted with a) C 1-6 alkoxy, b) C 1-6 alkylthio, c) CN, d) OH, or e) CF 3 , 3) CF 3 , 4) nitro, 5) amino, 6) cyano, 7) C 1-6 alkylamino, 8) halogen 9) OR c , 10) OCH 2 R c , and 11) CH 2 OR c ; R c is 1) C 6-10 aryl, 2) C 5-10 heteroaryl, 3) C 3-10 heterocycloalkyl, or 4) C 3-8 cycloalkyl.