Patent ID: 7718671

Claim:
A compound having the formula or a pharmaceutically acceptable salt thereof, wherein: z is 0, 1, or 2; R is hydrogen; R 1 , and R 4 , and R 5 are each independently hydrogen, halogen, or methyl; When z is 0; one of R 2 and R 3 is hydrogen, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, trifluoromethyl, or trifluoromethoxy; and the other of R 2 and R 3 is (a) C 3 -C 6 alkyl or C 3 -C 6 alkoxy, each of which is substituted with at least one mono- or di-C 1 -C 4 alkylamino; (b) C 4 -C 8 alkoxycarbonyl; (c) (phenyl)C 1 -C 2 alkoxy, (phenyl)C 1 -C 2 alkylamino, (phenylamino)C 1 -C 2 alkyl, (cyclohexyl)CH 2 O—, or indanyl-2-yloxy; or (d) (cyclohexyl)C 0 -C 2 alkyl or (piperidinyl)C 0 -C 2 alkyl, each of which is fused to a 6-membered carbocyclic ring; wherein each of (a), (b), (c), and (d), is substituted with 0 to 3 substituents independently chosen from halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and phenyl; (e) cyclohexyl, piperidinyl, or bridged cyclohexyl each of which is substituted with at least one substituent chosen from C 2 -C 6 alkoxycarbonyl, phenyl, C 4 -C 8 alkyl, and C 4 -C 8 alkoxy; and further substituted with 0 to 3 substituents independently chosen from halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; or one of R 2 and R 3 is halogen, C 1 -C 2 alkoxy, C 1 -C 2 haloalkyl, or C 1 -C 2 haloalkoxy, and the other is cyclohexyl, piperidinyl, C 5 -C 8 alkyl, C 5 -C 8 alkenyl, C 5 -C 8 alkynyl, or C 4 -C 8 alkoxy; When z is 1 or 2, one of R 2 and R 3 is hydrogen, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, trifluoromethyl, or trifluoromethoxy; and the other of R 2 and R 3 is (i) C 3 -C 6 alkyl or C 3 -C 6 alkoxy, substituted with at least one mono- or di-C 1 -C 4 alkylamino; (ii) C 4 -C 8 alkoxycarbonyl, C 5 -C 8 alkenyl, or C 5 -C 8 alkynyl; (iii) (phenyl)L which is optionally fused to a 6-membered carbocyclic ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms independently chosen from N, O, and S; where L is C 0 -C 3 alkyl, —C(phenyl) 2 -, C 0 -C 2 alkoxy, —O—C 1 -C 2 alkyl, or —NH—C 1 -C 2 alkyl-; (iv) (piperidinyl)C 0 -C 2 alkyl or (cyclohexyl)C 0 -C 2 alkyl or; each of which is optionally fused to a 6-membered carbocyclic ring; (v) bridged cyclohexyl; wherein each of (i), (ii), (iii), (iv), and (v) is substituted with 0 to 3 substituents independently chosen from halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, mono- and di-(C 1 -C 4 alkyl)amino, C 2 -C 6 alkoxycarbonyl, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy, and phenyl; or one of R 2 and R 3 is halogen, C 1 -C 2 alkoxy, C 1 -C 2 haloalkyl, or C 1 -C 2 haloalkoxy, and the other is C 5 -C 8 alkyl or C 4 -C 8 alkoxy; with the proviso that R 2 is not benzyloxy or cyclopentyloxy when R 3 is methoxy; and R 6 and R 7 , when present, are independently chosen at each occurrence from hydrogen, methyl and ethyl; or R 6 and R 7 may be joined to form a 5- to 6-membered cycloalkyl ring.