Patent ID: 8778941

Claim:
A compound of Formula I having the structure: or a pharmaceutically-acceptable salt thereof, a tautomer thereof, a pharmaceutically-acceptable salt of the tautomer, a stereoisomer thereof, or a mixture thereof, wherein: m is 0; n is 0 or 1; X 1 is CH; X 2 is N; Y is NH; Z is O; R 1 is and the symbol , when drawn across a bond, indicates the point of attachment to the rest of the molecule; R 2 is F or CF 3 ; R 3 is CF 3 or OCF 3 ; R 4 is F or H; R 5 is independently, in each instance, Cl, Br, F, CH 3 , CF 3 , or OR a ; R 6 is F, CF 3 , C 1-6 alk, or OR a ; R a is independently, at each instance, H or R b ; and R b is independently, at each instance, phenyl, benzyl or C 1-6 alk, the phenyl, benzyl and C 1-6 alk being substituted by 0, 1, 2 or 3 substituents selected from halo, oxo, C 1-4 alk, C 1-3 haloalk, —OC 1-4 alk, —OH, —NH 2 , —OC 1-4 alk, —OC 1-4 haloalk, —NHC 1-4 alk, and —N(C 1-4 alk)C 1-4 alk.