Patent ID: 7388002

Claim:
A compound represented by the formula: wherein A is selected from the group consisting of (CH 2 ) n R 2 , —CH═CH 2 , CH 2 —CH═CH 2 , O(CH 2 ) n R 2 , CH(OH)CH 3 , CH(OH)CH 2 OH, CH 2 —CH(OH)CH 3 , and CH 2 CH(OH)CH 2 OH, CH(OH)CH(OH)CH 3 , R is selected from the group consisting of, aryl, substituted aryl, heterocycle, NR 3 R 4 , and OR 3 , provided that both R and R 1 cannot both be OR 3 , R 1 is selected from the group consisting of H, Cl, Br, I, aryl, substituted aryl, heterocycle, NR 3 R 4 , OR 3 , and SR 3 , R 2 is selected from the group consisting of H, OH, F, N 3 , NH 2 , CO 2 H, SH, alkyl, substituted alkyl, S-alkyl, O-acyl, CONH 2 , and CONH-alkyl, n is an integer of 1-3, y is selected from the group consisting of O, S and NH, W is selected from the group consisting of O and S, Z and Z′ are individually selected from the group consisting of O(CH 2 ) m —O—(CH 2 ) x CH 3 , NH—CH(alkyl)CO 2 R 3 , alkyl, substituted alkyl, OCH 2 CH 2 S—C(O)CH 3 , OCH 2 CH 2 S—C(O)CH(CH 3 ) 2 , OCH 2 CH 2 S—C(O)C(CH 3 ) 3 , OCH 2 CH 2 —SC(O)aryl, OCH 2 CH 2 —S—S—OCH 2 CH 2 OH, OCH 2 OC(O)C(CH 3 ) 3 , OCH 2 —O—C(O)OCH(CH 3 ) 2 , and OCH 2 —O—C(O)CH(CH 3 ) 2 , R 3 and R 4 are individually selected from the group consisting of H, alkyl, substituted alkyl, aryl, and substituted aryl; additionally, R 3 and R 4 of NR 3 R 4 can form a monocyclic ring of 4-7 atoms with N or optionally a further heteroatom in the ring, m is an integer of 1-3, x is an integer of 0-19; and pharmaceutically acceptable salts thereof and prodrugs thereof.