Patent ID: 7012077

Claim:
A compound of the formula wherein U is O or a lone pair, V is a single bond, O, S, —CH═CH—CH 2 —O—, —CH═CH—, or —C≡C—, m and n independently from each other are 0 to 7 and m+n is 0 to 7, with the proviso that m is not 0 if V is O or S, o is 0 to 2 A 1 is hydrogen, lower-alkyl, hydroxy-lower-alkyl, or lower-alkenyl, A 2 is lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, or lower-alkenyl, optionally substituted by R 1 , or A 1 and A 2 are bonded to each other to form a ring and -A 1 -A 2 - is lower-alkylene or lower-alkenylene, optionally substituted by R 1 , in which one —CH 2 — group of -A 1 -A 2 - can optionally be replaced by NR 2 , S, or O, A 3 and A 4 independently from each other are hydrogen or lower-alkyl, or A 3 and A 4 are bonded to each other to form a ring together with the carbon atom to which they are attached and -A 3 -A 4 - is —(CH 2 ) 2-5 —, A 5 is hydrogen, lower-alkyl, or lower-alkenyl, A 6 is pyrimidinyl, optionally substituted with 1 or 2 substituents independently selected from the group consisting of lower-alkyl, lower-alkyl-cycloalkyl, thio-lower-alkoxy, cycloalkyl, carbamoyl, carboxy, carboxy-lower-alkyl, cyano, amino, mono- and dialkylamino, lower-alkoxy, lower-alkoxy-lower-alkyl, lower-alkoxy-carbonyl, lower-alkoxy-carbonyl-lower-alkyl, lower-alkenyl, lower-alkynyl, aryl, aryl-lower-alkyl, aryloxy, halogen, heteroaryl, heterocyclyl, heterocyclyl-lower-alkyl and trifluoromethyl, R 1 is hydroxy, hydroxy-lower-alkyl, lower-alkoxy, lower-alkoxycarbonyl, halogen, CN, N(R 3 ,R 4 ), or thio-lower-alkoxy, R 2 , R 3 , and R 4 independently from each other are hydrogen or lower-alkyl, or a pharmaceutically acceptable salt thereof, with the proviso that the compound of formula (I) is not trans-[4-(2-dipropylamino-ethyl)-cyclohexyl]-pyrimidin-2-yl-amine.