Patent ID: 8188112

Claim:
A method of reducing the proliferation of a targeted cell, wherein the cell is a cell of a cancer selected from cervical cancer, metastatic neuroblastoma and osteosarcoma, the method comprising exposing the cell to an effective amount of a compound of general formula (I): and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers thereof, wherein X, X′ and X″ are independently O or S; Z is N; R 3 is optional and is selected from the group consisting of optionally substituted C 1-8 alkylene optionally substituted C 2-6 alkenylene, and optionally substituted C 2-6 alkynylene; R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are independently selected from the group consisting of hydrogen, optionally substituted C 1-8 , alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally C 1-6 thioalkyl, optionally substituted C 5-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 ) alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 4 -C 10 ) aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; and - - - indicates an optional double bond.