Patent ID: 8076477

Claim:
A method for purifying a proteinaceous material, wherein said method comprises contacting a sample containing a proteinaceous material with an affinity adsorbent of formula III wherein R 1 is an aryl or aromatic heterocyclic group which may contain a further fused ring and can be substituted with one or more of alkyl, aryl, alkoxy, aryloxy, acyloxy, acylamino, amino, OH, CO 2 H, sulphonyl, carbamoyl, sulphamoyl, alkylsulphonyl and halogen; X is N; Y is O, S or NR 2 ; Z is O, S or NR 3 ; R 2 and R 3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl; Q is benzene, naphthalene, benzthiazole, benzoxazole, 1-phenylpyrazole, indazole or benzimidazole; R 4 , R 5 and R 6 are each H, OH, alkyl, aryl, heterocyclic, alkoxy, aryloxy, amino, acyloxy, acylamino, CO 2 H, sulphonic acid, carbamoyl, sulpharnoyl, alkylsulphonyl or halogen, and QR 4 R 5 R 6 is or includes a cyclic structure; U and V are the same or different C 1-10 straight-chain alkylene groups and U and/or V is substituted by OH; and A is a support matrix optionally linked to the X-containing ring by a spacer.