Patent ID: 7132419

Claim:
A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I) wherein each of R 1 to R 3 , is from hydrogen, and R 4 is selected from halogen, hydroxyl, C 1 –C 6 alkoxy which is unsubstituted or substituted, heteroaryloxy, nitro, cyano, azido, amidoxime, CO 2 R 10 , CON(R 12 ) 2 , OCON(R 12 ), SR 10 , SOR 11 , SO 2 R 11 , SO 2 N(R 12 ) 2 , N(R 12 ) 2 , NR 10 SO 2 R 11 , N(SO 2 R 11 ) 2 NR 10 (CH 2 ) n CN, NR 10 COR 11 , OCOR 11 or COR 10 ; each of R 5 to R 7 , which are the same or different, is selected from hydrogen, halogen, hydroxy, C 1 –C 6 alkoxy, C 1 –C 6 alkyl, SR 10 and N(R 12 ) 2 ; Q is C 1 –C 6 alkylene which is unsubstituted or substituted by (i) C 1 –C 6 alkyl which is unsubstituted or substituted, (ii) hydroxy, provided that the hydroxy group is not α to either of the N atoms adjacent to Q in formula (I), (iii) CO 2 R 10 , or (iv) CON(R 12 ) 2 ; R 8 and R 9 , which are the same or different, are each hydrogen or C 1 –C 6 alkyl, or R 8 and R 9 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered N-containing heterocyclic ring which may include one additional heteroatom selected from O, N and S, or one of R 8 and R 9 is an alkylene chain optionally interrupted by O, N or S, which is attached to a carbon atom on the alkylene chain represented by Q to complete a saturated 5- or 6-membered N-containing heterocyclic ring as defined above; R 10 is hydrogen, C 1 –C 6 alkyl, C 3 –C 6 cycloalkyl, benzyl or phenyl; R 11 is C 1 –C 6 alkyl, C 3 –C 6 cycloalkyl, benzyl or phenyl; each R 12 , which are the same or different, is hydrogen, C 1 –C 6 alkyl cycloalkyl, benzyl or phenyl, or the two R 12 groups form, together with the nitrogen atom to which they are attached a 5- or 6-membered saturated N-containing heterocyclic ring which may include 1 or 2 additional heteroatoms selected from O, N and S; and n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.