Patent ID: 7041276

Claim:
A method of screening a candidate agent for an activity that is potentially useful in treatment or prophylaxis of diseases involving angiogenic processes, wherein the activity is an enhancement, inhibition, or prevention of a formation or outgrowth of a blood vessel or a lymph vessel, and wherein the method comprises the steps of: (i) administering the agent to a teleost, (ii) measuring formation or outgrowth of a blood vessel or a lymph vessel in the teleost; (iii) comparing the formation or outgrowth of a blood vessel or a lymph vessel in the teleost administered the agent with the formation or outgrowth of a blood vessel or a lymph vessel in a control teleost, which was not administered the candidate agent; wherein a change in the formation or outgrowth of a blood vessel or a lymph vessel in the teleost administered the candidate agent compared to the formation or outgrowth of a blood vessel or a lymph vessel in the control teleost indicates that the agent is an agent having an activity that is potentially useful in treatment or prophylaxis of diseases involving angiogenic processes.