Patent ID: 7994161

Claim:
A compound of formula (I) wherein: a) R 1 is independently chosen from the group consisting of (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkyl(C1-C12)alkyl, cycloalkyl(C2-C12)alkenyl, cycloalkyl(C2-C12)alkynyl, heterocyclyl(C1 -C12)alkyl, heterocyclyl(C2-C12)alkenyl, heterocyclyl(C2-C12)alkynyl, aryl(C1-C12)alkyl, aryl(C2-C12)alkenyl, aryl(C2-C12)alkynyl, heteroaryl(C1-C12)alkyl, heteroaryl(C2-C12)alkenyl, and heteroaryl(C2-C12)alkynyl, the aryl group of each R 1 being optionally substituted with one or more halogens; b) R 2 is chosen from the group consisting of (C1-C6)alkyl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl, heteroaryl, (C1-C6)alkylthio(C1-C6)alkyl, di(C1-C6)alkylamino(C1-C6)alkyl, aryloxy(C1-C6)alkyl, and (C1-C6)alkoxy(C1-C6)alkyl; c) R 3 is chosen from the group consisting of H, COO(R 5 ), CONH(R 5 ), CO(R 5 ), O(R 5 ), and R 5 ; d) R 4 is independently chosen from the group consisting of H, F, Cl, Br, N(R 5 ) 2 , NO 2 , CN, COO(R 5 ), CON(R 5 ) 2 , NHCO(R 5 ), NHCOO(R 5 ), OCONH(R 5 ), O(R 5 ), and R 5 or alternatively two substituents R 4 linked to 2 adjacent carbons of the phenyl form together a ring chosen from cycloalkyl, heterocyclyl, aryl and heteroaryl, optionally substituted with one or more R 4 ; e) X 1 is —CH 2 —; X 2 is independently chosen from the group consisting of O, and N(R 5 ), or alternatively, X 1 and X 2 form together a divalent group independently chosen from —N═C(R 5 )— and —N(R 5 )—C(R 5 )(R 5 )—, it being possible for the two substituents R 5 to be identical or different; f) m has the value 0, 1, 2, 3, or 4; g) R 5 is independently chosen from non-bonding electron doublet, H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, halo(C1-C12)alkyl, aryl(C1-C12)alkyl, heteroaryl(C 1-C12)alkyl, heteroarylaryl(C1-C12)alkyl, aryl, heteroaryl and cycloalkyl, in which each R 5 is optionally substituted with at least one substituent chosen from OH, halogen, (C1-C4)alkyl, (C1-C4)alkoxy, aryl(C1-C4)alkyl, aryl, heteroaryl(C1-C4)alkyl, heteroaryl, —N(CH 3 ) 2 , —NH 2 , CONH 2 , each of the Rz is independently chosen from the group consisting of H, COO(R 5 ), CONH(R 5 ), CON(R 5 ) 2 , CO(R 5 ) and R 5 , in which each R 5 is independently chosen from (C1-C4)alkyl, halo(C1-C4)alkyl, aryl(C1-C4)alkyl,and heteroaryl(C1-C4)alkyl, in which each R 5 is optionally substituted with one substituent chosen from OH, halogen, (C1-C4)alkyl, (C1-C4)alkoxy, aryl(C1-C4)alkyl, aryl, heteroaryl(C1-C4)alkyl and heteroaryl; or a pharmaceutically acceptable acid addition salt of such compound, wherein heteroaryl is a monocyclic or polycyclic heteroaromatic substituent containing from 1 to 13 carbon atoms and from 1 to 4 heteroatoms selected from oxygen, sulphur, nitrogen and selenium, and heterocyclyl is a saturated or partially unsaturated cyclic hydrocarbon based substituent containing from 1 to 13 carbon atoms and from 1 to 4 heteroatoms selected from oxygen, sulphur, nitrogen and selenium.