Patent ID: 8729081

Claim:
A compound having a structural formula (IIa): or a salt, solvate, ester or prodrug thereof, wherein: R 1 is —C(O)NR 5 R 6 ; R 2 is hydrogen, C 1-6 alkyl, or substituted C 1-6 alkyl; —NR 5 R 6 is derived from a group consisted of 3-(Azepan-1-yl)propan-1-amine (Cpd A), X is —CH 2 —; Z 1 is N; Z 2 is CR 12 or N; R 12 is hydrogen, alkyl, or substituted alkyl; n is an integer from 0 to 2; m is 0; and each R 11 is independently selected from the group consisting of halogen, C 1-6 acyl, substituted C 1-6 acyl, C 1-6 alkoxycarbonyl, substituted C 1-6 alkoxycarbonyl, C 6-10 aryloxycarbonyl, substituted C 6-10 aryloxycarbonyl, —C(O)NR 5 R 6 , C 2-6 alkyl, substituted C 2-6 alkyl, C 6-10 aryl, substituted C 6-10 aryl, C 6-20 arylalkyl, substituted C 6-20 arylalkyl, C 3-7 cycloheteroalkyl, substituted C 3-7 cycloheteroalkyl, C 6-10 heteroaryl, substituted C 6-10 heteroaryl, C 6-20 heteroarylalkyl, substituted C 6-20 heteroarylalkyl, C 1-6 heteroalkyl, and substituted C 1-6 heteroalkyl; wherein R 5 and R 6 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heteroalkyl, or substituted heteroalkyl, or alternatively, R 5 and R 6 , taken together with the nitrogen atom to which they are attached, form a 4-, 5-, 6-, or 7-membered cycloheteroalkyl ring.