Patent ID: 8563022

Claim:
A method of designing and fabricating particles having an enhanced adherence to cells of a target site, the method comprising (A) selecting a target site having a surface, said surface having one or more first moieties; (B) selecting second moieties that are capable of binding to the first moieties; (C) selecting a numerical value for a spheroid aspect ratio of a spheroidal particle; (D) calculating the numerical value of volume that maximizes the adherence strength of the spheroidal particle to the target site using the following input parameters; (i) the selected numerical value of the spheroid aspect ratio; (ii) the area of interaction ¶r 0 2 between the spheroidal particle and the target site, where r 0 is the radius of the spheroidal particle; and (iii) the numerical value of the surface density of the first moieties on the target site, wherein the volume of the spheroidal particle (V) is related to the aspect ratio (γ) as V=4/3¶a 3 γ −1 , and γ=a/b, where a and b represent half-lengths of two axes of the spheroidal particle, and γ≧1; (E) fabricating the spheroidal particle, that has a spheroid aspect ratio substantially equal to the selected numerical value and a volume that has a numerical value that is substantially equal to the calculated numerical value of the maximizing volume; and (F) disposing the second moieties on a surface of the particle wherein the particles obtained have an enhanced adherence to cells of the target site.