Patent ID: 8609833

Claim:
A compound having the formula or a pharmaceutically acceptable salt thereof, wherein A is —CH 2 OSO 2 NH 2 ; B and C are —OH; D is A and B are trans with respect to each other; B and C are cis with respect to each other; C and D are cis or trans with respect to each other; R 1 is —C 3 -C 8 monocyclic cycloalkyl, —C 3 -C 8 monocyclic cycloalkenyl, —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkyl), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkenyl), —C 8 -C 12 bicyclic cycloalkyl, or —C 8 -C 12 bicyclic cycloalkenyl; R 2 is -halo, —CN, —NHR 8 , —OR 8 , —SR 8 , —NHC(O)OR 8 , —NHC(O)R 4 , —NHC(O)NHR 8 , —NHNHC(O)R 4 , —NHNHC(O)OR 8 , —NHNHC(O)NHR 8 , or —NH—N═C(R 6 )R 7 ; R 4 is —H, —C 1 -C 15 alkyl, -aryl, —(CH 2 ) n -aryl, —(CH 2 ) n -(3- to 7-membered monocyclic heterocycle), —(CH 2 ) n -(8- to 12-membered bicyclic heterocycle), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkyl), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkenyl), —(CH 2 ) n (—C 8 -C 12 bicyclic cycloalkyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkenyl), —C≡C—(C 1 -C 10 alkyl) or —C≡C-aryl; R 6 is —C 1 -C 10 alkyl, -aryl, —(CH 2 ) n -aryl, —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkyl), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkenyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkenyl), —(CH 2 ) n -(3- to 7-membered monocyclic heterocycle), —(CH 2 ) n -(8- to 12-membered bicyclic heterocycle), -phenylene-(CH 2 ) n COOH, or -phenylene-(CH 2 ) n COO—(C 1 -C 10 alkyl); R 7 is —H, —C 1 -C 10 alkyl, -aryl, —(CH 2 ) n -aryl, —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkyl), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkenyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkenyl), —(CH 2 ) n -(3- to 7-membered monocyclic heterocycle), or —(CH 2 ) n -(8- to 12-membered bicyclic heterocycle); R 8 is —C 1 -C 15 alkyl, -aryl, —(CH 2 ) n -aryl, —(CH 2 ) n -(3- to 7-membered monocyclic heterocycle), —(CH 2 ) n -(8- to 12-membered bicyclic heterocycle), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkyl), —(CH 2 ) n —(C 3 -C 8 monocyclic cycloalkenyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkyl), —(CH 2 ) n —(C 8 -C 12 bicyclic cycloalkenyl), —C≡C—(C 1 -C 10 alkyl) or —C≡C-aryl; and each n is independently an integer ranging from 1 to 5.