Patent ID: 8906914

Claim:
A compound of Formula (I): wherein R 1 is —H, —C(O)CF 3 , or —CO 2 C(CH 3 ) 3 ; Ar 1 is phenyl, napthyl, a 5 or 6 membered monocyclic heteroaryl group with carbon at the point of attachment, or a 9 or 10 membered bicyclic heteroaryl group with carbon at the point of attachment, each unsubstituted or substituted with; (i) one, two, or three R c moieties, where each R c moiety is independently —C 1-4 alkyl, —C 1-4 alkyl-OH, —C 1-4 alkyl-CN, —OH, —OC 1-4 alkyl, perfluoroalkyl, perfluoroalkoxy, —S(O) 0-2 C 1-4 alkyl, —SCF 3 , —SO 2 CF 3 , —CHO, —COC 1-4 alkyl, —CO 2 C 1-4 alkyl, —CO 2 H, —N(R d )R e , —SO 2 NR d R e , —NR d SO 2 R e , —C(O)NR d R e , —NO 2 , —CN, imidazolyl, phenyl, pyridyl, pyrrolidinyl, thiophenyl, or halo, where R d and R e are each independently H or —C 1-4 alkyl, or taken together R d and R e with the nitrogen of attachment form a 4-7 membered heterocycloalkyl ring; or (ii) two or three R c moieties where two R c moieties are adjacent to each other and together form —O(CH 2 ) 1-3 O— unsubstituted or substituted with one or two fluoro groups, and the third R c moiety, when present, is —C 1-4 alkyl, —C 1-4 alkyl-OH, —C 1-4 alkyl-CN, perfluoroalkyl, —OH, —OC 1-4 alkyl, perfluoroalkoxy, —S(O) 0-2 C 1-4 alkyl, —SCF 3 , —SO 2 CF 3 , —CHO, —COC 1-4 alkyl, —CO 2 C 1-4 alkyl, —CO 2 H, —N(R d )R e , —SO 2 NR d R e , —NR d SO 2 R e , —C(O)NR d R e , —NO 2 , —CN, or halo, where R d and R e are each independently —H or —C 1-4 alkyl; Ar 2 is: (i) phenyl substituted with; one, two, or three R g moieties each at a meta or para position, and optionally with one or two additional R g moieties at an ortho position; where each R g moiety is independently halo, OH, —C 1-4 alkyl, —C 1-4 alkyl-OH, —C 1-4 alkyl-CN, perfluoroalkyl, perfluoroalkoxy, —OC 1-4 alkyl, —OC 1-4 alkyl-(monocyclic cycloalkyl), —S(O) 0-2 C 1-4 alkyl, —SCF 3 , —SO 2 CF 3 , —CHO, —COC 1-4 alkyl, —CO 2 C 1-4 alkyl, —CO 2 H, —N(R h )R i , —SO 2 NR j R k , —NR h SO 2 R i , —C(O)NR j R k , —NO 2 , —CN; or a phenoxy, benzyl, phenethyl, or benzoyl group unsubstituted or substituted with —C 1-4 alkyl, —OC 1-4 alkyl, perfluoroalkyl, perfluoroalkoxy, —NO 2 , —CN, or halo; or two adjacent R g moieties taken together form —O(CH 2 ) 1-2 O— unsubstituted or substituted with one or two fluoro groups; where R h is H or —C 1-4 alkyl; R i is —C 1-4 alkyl or monoyclic cycloalkyl group; or R h and R i taken together with the atoms to which they are attached form a monocyclic heterocycloalkyl ring; R j is H or —C 1-4 alkyl; and R k is H, —C 1-4 alkyl or monoyclic cycloalkyl group; or R j and R k taken together with the atoms to which they are attached form a monocyclic heterocycloalkyl ring; or (ii) a monocyclic heteroaryl group substituted with one, two, or three R g moieties; or (iii) a naphthyl or bicyclic heteroaryl group unsubstituted or substituted with one, two, or three R l moieties; where each R l moiety is independently —C 1-4 alkyl, —OC 1-4 alkyl, perfluoroalkyl, perfluoroalkoxy, —NO 2 , —CN, or halo; or a pharmaceutically acceptable salt of said compound.