Patent ID: 8247375

Claim:
Epidermal growth factor receptor (EGFR) binding polypeptide, comprising an epidermal growth factor receptor binding motif, EBM, which motif consists of an amino acid sequence selected from: EX 2 X 3 X 4 AX 6 X 7 EIR X 11 LPNLNGWQX 20 TAFIX 25 SLX 28 D, wherein, independently of each other, X 2 is selected from M, V, L, and I; X 3 is selected from W, D, and E; X 4 is selected from I, V, G, S, M, L, A, T, N, and D; X 6 is selected from W, V, and I; X 7 is selected from D, E, N and K; X 11 is selected from D, N, E, Y and S; X 20 is selected from M, L, and F; X 25 is selected from A, S, and G; and X 28 is selected from L, V, and F; and ii) an amino acid sequence which has at least 85% identity to the sequence defined in i); the EGFR-binding polypeptide binding to EGFR such that the K D value of the interaction is at most 10 μM.