Patent ID: 6846825

Claim:
A compound of formula (II), or a pharmaceutically or veterinarily acceptable salt, hydrate or solvate thereof wherein Q represents a radical of formula —N(OH)CH(═O) or formula —C(═O)NH(OH); R 1 represents hydrogen, C 1 -C 6 alkyl or C 1 -C 6 alkyl substituted by one or more halogen atoms, or, except when Q is a radical of formula —N(OH)CH(═O), a hydroxy, C 1 -C 6 alkoxy, C 2 -C 6 alkenyloxy, amino, C 1 -C 6 alkylamino, or di-(C 1 -C 6 alkyl)amino group; R 2 represents a substituted or unsubstituted C 1 -C 6 alkyl, cycloalkyl (C 1 -C 6 alkyl)- or aryl(C 1 -C 6 alkyl)-group; and A represents a group of formula (IIA), or (IIB): wherein R 4 represents the side chain of a natural or non-natural alpha amino acid; and R 5 and R 6 are taken together with the nitrogen atom to which they are attached to form a 1-piperazin-4-yl ring which is optionally fused to a saturated or unsaturated carbocyclic or heterocyclic second ring of 5 to 7 atoms; wherein (a) the second ring is substituted by (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, hydroxy, mercapto, (C 1 -C 6 )alkylthio, halo, amino, trifluoromethyl, oxo, nitro, —COOH, —CONH 2 , —COR A , —COOR A , —NHCOR A , —CONHR A , —NHR A , —NR A R B , or —CONR A R B wherein R A and R B are independently a (C 1 -C 6 )alkyl group; and/or (b) the piperizinyl ring or second ring is substituted by a group of formula (IIC), provided that the piperizinyl ring is not substituted by phenoxy, benzyl or benzyl substituted by (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, phenoxy, hydroxy, mercapto, (C 1 -C 6 )alkylthio, amino, halo, trifluoromethyl, nitro, —COOH, —CONH 2 , —COR A , —COOR A , —NHCOR A , —CONHR A , —NHR A , —NR A R B , or —CONR A R B wherein R A and R B are independently a (C 1 -C 6 )alkyl group, wherein m, p and n are independently 0 or 1; Z represents, a hydroxy group, or a phenyl or heterocyclic ring of 5 to 7 atoms which is optionally fused to a saturated or unsaturated carbocyclic or heterocyclic second ring of 5 to 7 atoms Alk 1 and Alk 2 independently represent divalent C 1 -C 3 alkylene radicals; X represents —O—, —S—, —S(O)—, —S(O 2 )—, —C(═O)—, —NH—, —NR 7 — where R 7 is C 1 -C 3 alkyl; and wherein Alk 1 and Alk 2 and Z when Z is not a hydroxy group indepently or optionally substituted by (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl, phenyl, or halophenyl, trifluoromethyl, monocyclic 5 or 6-membered heterocyclic, benzyl, or halophenylmethyl, hydroxy, phenoxy, (C 1 -C 6 )alkoxy, or hydroxy(C 1 -C 6 )alkyl, mercapto, (C 1 -C 6 )alkylthio or mercapto(C 1 -C 6 )alkyl, oxo, nitro, cyano (—CN) halo (bromo, chloro, fluoro, or iodo) —COOH, or —COOR A , —CONH 2 , —CONHR A , —CONR A R B —COR A , —SO 2 R A , —NHCOR A , —NH 2 , —NHR A , or —NR A R B , wherein R A and R B are independently a (C 1 -C 6 )alkyl group, R A and R B taken together with the nitrogen atom to which they are attached form a 5- or 6 membered heterocyclic ring which may be substituted by (C 1 -C 3 )alkyl, hydroxy, or hydroxyl(C 1 -C 3 )alkyl.