Patent ID: 8093227

Claim:
A monosaccharide compound of Formula I: in which the monosaccharide ring is of the glucosamine or galactosamine configuration; R 3 is a carboxylic acid mimetic selected from the group consisting of: in which A and B are independently hydrogen, alkyl, trihaloalkyl or halo; A 11 is hydroxy, optionally substituted carboxy or oxyaryl; U is H, aryl, heteroaryl, alkyl, alkenyl or alkynyl each of which are optionally substituted with one or more of OH, SH, CF 3 , alkyl, alkenyl, alkynyl, NO 2 , halo, SO 3 H, NH 2 , CO 2 H, azido, nitroso, alkoxy, SO 2 NH 2 , amidine or guanidinium; and R is O—Y, or in which Y is, in which Z 1 is selected from halo, optionally substituted S-aryl, optionally substituted S-heteroaryl, optionally substituted aryl or optionally substituted heteroaryl; X is selected from O, NH or S; Y 1 is selected from: (a) optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkyl, optionally substituted arylalkyl, or (b) any one of: in which Z 111 is selected from O, NH or S; R 6 is selected from H, CONH 2 or COOH; n is an integer of 0 to 4; R 7 is selected from optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl; R 8 is selected from H, OH, NH 2 , alkyl, alkenyl or alkynyl; R 9 is selected from H, OH, NH 2 , or NHCO—R 10 in which R 10 is an optionally substituted alkyl; R 11 is selected from an optionally substituted alkylene, optionally substituted cycloalkyl, optionally substituted heterocyclyl or optionally substituted heteroaryl; and R 1 is selected from an optionally substituted acetyl, an optionally substituted C 3-8 acyl, an optionally substituted benzoyl, an optionally substituted napthoyl, an optionally substituted biphenylcarbonyl, a heteroaryl acyl, an optionally substituted bicycloacyl, an optionally substituted bicycloheteroacyl, wherein the substituent or optional substituent is selected from at least one of OH, SH, CF 3 , alkenyl, alkynyl, NO 2 , halo, SO 3 H, NH 2 , CO 2 H, azido, nitroso, alkoxy, SO 2 NH 2 , amidine or guanidinium.