Patent ID: 8101625

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is O; R 1 is phenyl, —NH-phenyl, pyrrol, pyridinyl, dihydropyridinyl or indole, wherein each phenyl, —NH-phenyl, pyrrol, pyridinyl, dihydropyridinyl, and indole are optionally substituted with one or more groups independently selected from halo, —OH, —(C 1 -C 6 )alkyl, —CF 3 , —O(C 1 -C 6 )alkyl-phenyl, —N-phenyl, —(C 1 -C 6 )alkyl-phenyl, —O(C 1 -C 6 )alkyl, -(5-10 membered)heteroaryl, —(C 1 -C 6 )alkoxy, —(C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy, —O(C 1 -C 6 )alkyl-N[(C 1 -C 6 )alkyl] 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)NH(C 1 -C 6 )alkyl-N[(C 1 -C 6 )alkyl] 2 , —C(O)NH(C 1 -C 6 )alkylNH 2 , —O—(C 1 -C 6 )alkyl-C(O)NH(C 1 -C 6 )alkyl-phenyl, —C(O)NH(C 1 -C 6 )alkyl-O—(C 1 -C 6 )alkyl, C(O)—N[(C 1 -C 6 )alkyl] 2 —N[(C 1 -C 6 )alkyl] 2 and oxo; R 2 is phenyl substituted in the ortho or meta positions with one or more groups independently selected from —O(C 1 -C 6 )alkyl-phenyl, —(C 1 -C 6 )alkyl-phenyl, —O(C 1 -C 6 )alkyl, -(5-10 membered)heteroaryl, —NH 2 , —(C 1 -C 6 )alkoxy, —(C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy, —O(C 1 -C 6 )alkyl-N[(C 1 -C 6 )alkyl] 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)NH(C 1 -C 6 )alkyl-N[(C 1 -C 6 )alkyl] 2 , —C(O)NH(C 1 -C 6 )alkylNH 2 , —O—(C 1 -C 6 )alkyl-C(O)NH(C 1 -C 6 )alkyl-phenyl, —C(O)NH(C 1 -C 6 )alkyl-O—(C 1 -C 6 )alkyl, and —C(O)—N[C 1 -C 6 )alkyl] 2 -N[(C 1 -C 6 )alkyl] 2 ; or R 2 is phenyl substituted with both Br and —CH 3 or both Br and —OCH 3 ; with the provisos that when one of R 1 phenyl, then R 2 is not or one of R 1 or R 2 is and the remaining R 1 or R 2 is wherein R 4 is selected from hydrogen, halo, —OH, —NH 2 , and —(C 1 -C 6 )alkyl; or one of R 1 or R 2 is an unsubstituted phenyl, and the remaining R 1 or R 2 is phenyl substituted with one —NH 2 and optionally one —(C 1 -C 6 )alkyl.