Patent ID: 8846650

Claim:
A method of treating a middle ear infection in a human patient comprising the steps of: (a) diagnosing the patient as having otitis media and an open tympanic membrane in at least one ear; and (b) topically applying into the ear canal of the patient's ear an aqueous suspension composition containing a combination of ciprofloxacin and dexamethasone, wherein the composition comprises a) 0.01-0.5% (wt.) dexamethasone; b) 0.1-0.4% (wt.) ciprofloxacin; c) a tonicity agent consisting essentially of NaCl in an amount sufficient to cause the composition to have an osmolality of about 250-350 mOsm; d) 0.1-0.5% (wt.) of a nonionic polymer; e) 0.01-0.2% (wt.) of a nonionic surfactant; and f) a buffer, wherein the composition has a pH from about 3-5.