Patent ID: 7915266

Claim:
A method of treating cancer in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of formula (II); wherein: said cancer is selected from breast cancer, colon cancer and ovarian cancer; and wherein: R 1 is selected from and C 6 -C 8 cycloalkyl; R 2 is a moiety of the formula R 3 is H, or C 1 -C 3 alkyl; R 4 is H, or C 1 -C 3 alkyl; or R 3 and R 4 optionally taken together form a form a 6 to 8 membered saturated heterocyclic ring having 1-2 nitrogen atoms, 0-1 oxygen atoms and 0-1 sulfur atoms, and optionally substituted with C 1 -C 3 alkyl; R 5 is H, or C 1 -C 3 alkyl or C 1 -C 3 fluoroalkyl; Y is H, F, CI, or a moiety of the formula —O(CH 2 ) n Q; n is an integer of 2,3 or 4; Q is —OH, or —NR 6 R 7 ; R 6 and R 7 are independently H, or C 1 -C 3 alkyl; or R 6 and R 7 when optionally taken together with the nitrogen atom to which each is attached form a 4 to 6 membered saturated heterocyclic ring having 1-2 nitrogen atoms, 0-1 oxygen atoms and 0-1 sulfur atoms, and optionally substituted with R 8 ; R 8 is C 1 -C 3 alkyl; L 1 , L 2 , L 3 , and L 4 are each independently H, F, Cl, Br or CF 3 ; X is Cl or Br; or pharmaceutically acceptable salts thereof.