Patent ID: 8263659

Claim:
A compound of the formula wherein R 1 is R 2 and R 3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, provided that at least one of R 2 and R 3 is other than hydrogen; R 4 is R 5 and R 6 are the same or different and are selected from hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, aralkyl or heteroaralkyl, provided that where one of R 5 and R 6 is hydrogen, the other is not alkyl or aralkyl; R 7 is heteroaryl or heteroaralkyl; R 8 is heteroaryl; R 9 is aryl, heteroaryl, alkyl, aralkyl, heteroaralkyl, or hydrogen; R 10 is hydrogen, halogen, cyano or alkyl; R 11 and R 12 are each independently selected from the group consisting of hydrogen, halogen, alkoxy, hydroxy, cyano, and alkyl; R 13 is carboxylic acid (COON) or esters thereof, phosphonic and phosphinic acid or esters thereof, sulfonic acid, tetrazole, hydroxamic acid, thiazolidinedione, or acylsulfonamide; R 14 and R 15 may be the same or different and are selected from hydrogen and alkyl, or R 14 and R 15 may be joined together forming a chain of 2 to 5 methylene groups [—(CH 2 ) m —, m=2, 3, 4 or 5], thus forming 3- to 6-membered cycloalkyl rings; R 16 is hydrogen or alkyl of 1 to 4 carbons; R 17 and R 18 are the same or different and selected from hydrogen, halogen and alkyl; n is 0 or an integer from 1 to 4; and X is oxygen (—O—), sulfur (—S—), sulfonyl (—SO 2 —), sulfenyl (—SO—), selenium (—Se—), carbonyl (—CO—), amino (—NH—) or methylene (—CH 2 —); and including all prodrugs, stereoisomers and pharmaceutically acceptable salts thereof.