Patent ID: 7015205

Claim:
A method for eliciting an anti-cancer immune response in a subject, which comprises: (a) administering a first recombinant vaccinia virus encoding at least one first immunostimulating molecule, wherein the first immunostimulating molecule is IL-2; and (b) administering a composition comprising antigen presenting cells, which are capable of inducing T cell activation, wherein the antigen presenting cells are dendritic cells and/or monocytes, and which are autologous or syngeneic, pulsed with a preparation comprising enucleated cytosol and cell membranes of cancer cells, which are derived from the subject or are the same cancer cell type as the patient-derived cancer cells, infected with a second recombinant vaccinia virus encoding at least one second immunostimulating molecule, wherein the second immunostimulating molecule is IL-2; and (c) wherein administration of said first recombinant vaccinia virus and said composition is at or near lymph node(s); and wherein administration of said first recombinant vaccinia virus is approximately 30 minutes prior to said composition.