Patent ID: 7442387

Claim:
A pharmaceutical composition for controlled release comprising a sized product, which comprises (a) a drug, wherein said drug is present at 10% w/w or less; (b) a polyethylene oxide with a viscosity-average molecular weight of 2,000,000 or more; (c) a size controlling agent, wherein said size controlling agent is one or two or more selected from the group consisting of polyethylene glycol that is solid at ordinary temperature, hydroxypropylmethyl cellulose of 2 to 15 mPa·s (2% w/v), hydroxypropyl cellulose of 2 to 10 mPa·s (2% w/v), and methyl cellulose of 2 to 15 mPa·s (2% w/v), wherein said drug, and said size controlling agent are sprayed as an aqueous solution or as a suspension onto said polyethylene oxide to form a sized product; and wherein said sized product is a collection of particles wherein the average diameter of said particles is approximately 60 to 300 μm and wherein the specific volume of said particles is 2.0 to 3.0 ml/g.