Patent ID: 7314845

Claim:
A method for reducing non-specific binding to an inorganic support comprising a supported catalyst system, said support having at least one functional group capable of non-specific binding, the method comprising: (a) providing an inorganic support having at least one function group capable of reacting non-selectively with a catalytic species, a reaction substrate, reaction product, or other molecule; (b) reacting said at least one functional group of the inorganic support with a reactant capable of forming a R 10 group on the support to provide at least one R 10 group on at least one surface of the inorganic support, wherein the R 10 group comprises at least one non-acidic, hydrophilic, hydroxyl containing organic group; (c) reacting the inorganic support with at least one linker to provide at least one linker attached to at least one surface of the support; and (d) reacting the linker with a catalytic species to immobilize the catalytic species on the support, wherein the R 10 group is present on the surface of the inorganic support in a concentration sufficient to reduce and/or prevent non-specific binding.