Patent ID: 8153104

Claim:
A powder formulation for use in a dry powder inhaler, said powder comprising: (a) microparticles of a low-dosage strength active ingredient for the treatment of respiratory diseases having a therapeutical nominal dose equal to or lower than 4 microgram on each actuation of a powder inhaler; and (b) microparticles of an excipient selected from the group consisting of glucose, arabinose, maltose, saccharose, dextrose, and lactose, wherein: both microparticles (a) and microparticles (b) have a d(0.1) higher than 0.5 microns and a d(0.9) lower than 60 microns; microparticles (b) of said excipient have a mass median diameter (MMD) of between 2 and 15 microns; microparticles (a) of said active ingredient have a mass median diameter (MMD) of between 1 and 4 microns; and microparticles (a) of said active ingredient and microparticles (b) of said excipient are present in a weight ratio of between 1:9 and 1:90.