Patent ID: 7407960

Claim:
A compound of the formula: wherein: R 1 is aryl or cycloalkyl optionally substituted with 1 to 3 substituents selected from alkyl, hydroxy, alkoxy, halogen, halogen substituted alkyl, phenyl, and phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF 3 ; R 2 is benzoxazolyl or benzothiazolyl optionally substituted with 1 to 3 substituents selected from alkyl, hydroxy, alkoxy, halogen, halogen substituted alkyl, phenyl, and phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF 3 ; X 1 is —(CR 15 R 16 ) p —, in which R 15 and R 16 are independently hydrogen, hydroxy, lower alkyl, or —C(O)OR 17 , in which R 17 is hydrogen, lower alkyl, or phenyl, or phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF 3 , and p is 1, 2 or 3; with the proviso that when p is 1, R 15 and R 16 cannot be hydroxy; R 21 is hydrogen or lower alkyl; T is oxygen or sulfur; Y and Z are —(CR 18 R 19 ) q — and q at each occurrence is 1, 2 or 3, in which R 18 and R 19 at each occurrence is hydrogen or lower alkyl; and R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 at each occurrence are hydrogen, lower alkyl, or —C(O)R, in which R is —OR 11 or —NR 11 R 12 , where R 11 and R 12 are hydrogen or lower alkyl; or R 3 and R 4 , R 5 and R 6 , R 7 and R 8 , R 9 and R 10 , when taken together with the carbon to which they are attached, represent carbonyl; Q is oxygen, sulfur, or —NR 20 —, in which R 20 is hydrogen or optionally substituted lower alkyl; and X 2 is a covalent bond or —(CR 18 R 19 ) q — wherein q at each occurrence is 1, 2 or 3, and R 18 and R 19 at each occurrence is hydrogen or lower alkyl.