Patent ID: 8426424

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is: R 2 is H or CH 3 ; Z is chosen from phenylene and pyridylidene wherein phenylene and pyridylidene are optionally substituted with one or more groups independently chosen from CN, halo, hydroxyl, optionally substituted lower alkyl, and optionally substituted lower alkoxy; which is optionally substituted with one or two groups chosen from hydroxy, cyano, halo, optionally substituted lower alkyl, and optionally substituted lower alkoxy; R 16 is independently chosen from hydrogen, cyano, optionally substituted cycloalkyl, and optionally substituted lower alkyl; D is —NHR 7 ; and R 7 is chosen from optionally substituted aryl and optionally substituted heteroaryl.