Patent ID: 8852638

Claim:
An injectable depot formulation, comprising: a biocompatible polymer comprising a copolymer of lactic acid and glycolic acid, wherein the biocompatible polymer has a number average molecular weight ranging from 1000 Daltons to 5000 Daltons; an organic solvent combined with the biocompatible polymer to form a viscous gel said solvent selected from the group consisting of benzyl alcohol, benzyl benzoate, ethyl benzoate, ethyl hydroxide, N-methy1-2-pyrrolidone, and mixtures thereof; and a small molecule drug selected from base and salt forms of risperidone incorporated in the viscous gel, wherein the small molecule drug is in the form of particles having a particle size less than 38 μm, wherein the salt forms of risperidone have less than 1 mg/mL solubility in water, and wherein the formulation exhibits an in vivo release profile having C max to C min ratio less than 200 over a period of one month.