Patent ID: 8541607

Claim:
A method for the treatment of a condition selected from atherosclerosis, endothelial dysfunctions, cardiac allograft vasculopathy, platelet activation, thrombosis, stroke, and/or tissue damage resulting from ischemia or ischemia reperfusion, or symptoms of the above-mentioned conditions, said method comprising administering to a patient a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: n is an integer of 0, 1, or 2, X represents —S(O) m —, —(C═O)— or a single bond, wherein m is an integer of 0, 1, or 2, with the proviso that when X represents —(C═O)— then n is 0, R represents hydrogen or is a residue R a , which residue R a is selected from the group consisting of: C 1-6 alkyl; C 2-6 alkenyl; C 3-8 cycloalkyl; C 3-8 cycloalkyl, wherein one CH 2 group is replaced by O, S, NH or NCH 3 ; C 4-8 cycloalkenyl; phenyl; pyridyl; thiophenyl; nitrosyl; S-cysteinyl; S-glutathionyl; and wherein R* is selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 4-8 cycloalkenyl, acetyloxy, hydroxyl, ONO 2 and halogen; and wherein R a optionally is substituted by one to three groups independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 4-8 cycloalkenyl, acetyloxy, hydroxyl, ONO 2 and halogen, provided that when RXS(O) n — and —ONO 2 are trans to each other with respect to the ring plane as depicted in formulae (Ia) and (Ib): then RXS(O) n — does not represent wherein Z is an C 1 -C 4 alkyl group, aryl group, or an aralkyl group.