Patent ID: 8277846

Claim:
A method of preparing a composition comprising a therapeutic agent and an inclusion complex of a cyclodextrin-containing polymer and a complexing agent of the formula: wherein Host/Guest is a guest moiety; J is —NH—, —C(═O)NH—(CH 2 ) d —, —NH—C(═O)—(CH 2 ) d —, —CH 2 SS—, —C(═O)O—(CH 2 ) e —O—P(═O)(O—(CH 2 ) e —Y)O—, a peptide or polypeptide residue, or —NH—(C═O)—CH(R 1 )—NH—(C═O)—CH(R 1 )—NH—; Y is an additional host-guest functionality; R 1 is —(CH 2 )—CO 2 H, an ester or salt thereof; or —(CH 2 ) a —CONH 2 ; PEG is —O(CH 2 CH 2 O) z —, where z varies from 2 to 500; L is —NH—, —NH—(C═O)—(CH 2 ) e —(C═O)—CH 2 —, —S(═O) 2 —HC═CH—, —SS—, —C(═O)O—, or a carbohydrate residue; a is 0 or 1; b is 0 or 1; d ranges from 0 to 6; e ranges from 1 to 6; m is 1; n ranges from 1 to 6; q is 1; w ranges from 1 to 5; y is 1; and x is 1, said method comprising: combining the cyclodextrin-containing polymer, the complexing agent and the therapeutic agent, thereby forming the composition.