Patent ID: 7033772

Claim:
A method for identifying an agent which is an inhibitor of FATP1, comprising the steps of: (a) introducing into cells one or more vectors comprising a gene encoding a cell surface protein and a nucleic acid encoding FATP1 comprising the amino acid sequence of SEQ ID NO:25; (b) contacting the host cells with an antibodies to said cell surface protein and labeled fatty acid substrate of FATP1; (c) contacting a first aliquot of the host cells with an agent being tested as an inhibitor of FATP1, while leaving a second aliquot of the host cells uncontacted with the agent; (d) identifying, in said first and second aliquots, host cells expressing said cell surface protein by detecting said antibody to said cell surface protein bound to the host cells; and (e) measuring, in the first and second aliquots, uptake of the fatty acid substrate of the host cells identified as expressing the cell surface protein; wherein less uptake of the fatty acid substrate in the first aliquot compared to the second aliquot is indicative that the agent is an inhibitor of FATP1.