Patent ID: 7160920

Claim:
A β-agonist compound of Formula (II): wherein, E is nitrogen or C—R 7 ; R 7 is hydrogen, halogen, —CH 2 O—R j , or —O—R j ; R j is hydrogen, D or M; D is (i) hydrogen (ii) —NO (iii) —NO 2 (iv) —CH(R d )—O—C(O)—Y—(C(R e )(R f )) p -T-Q; (v) —C(O)-T 1 -(C(R e )(R f )) p -T 2 -Q; or (vi) —C(O)-T-(C(R y )(R z )) p ; R d is hydrogen, lower alkyl, cycloalkyl, aryl, alkylaryl or heteroaryl; Y is oxygen, sulfur or NR i ; R i is hydrogen, lower alkyl, lower haloalkyl or heteroaryl; R e and R f are each independently hydrogen, lower alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, alkylamino, dialkylamino, or carboxy, or R e and R f taken together with the carbon atom to which they are attached are carbonyl, cycloalkyl or bridged cycloalkyl; p is an integer from 1 to 6; T, T 1 and T 2 are each independently a covalent bond, oxygen, sulfur or nitrogen; Q is —NO or —NO 2 ; with the proviso that in “T-Q” and “T 2 -Q”, T and T 2 cannot be a covalent bond; R y and R z are each independently -T 1 -(C(R e )(R f )) p -G-(C(R e )(R f )) p -T 2 -Q; G is a covalent bond, -T-C(O)—, —C(O)-T or Y; wherein R d , R e , R f , p, Q, T, T 1 , T 2 and Y are as defined herein; M is (i) —C(O)-T-(C(R e )(R f )) p -G-(C(R e )(R f )) p —N(N—(O − ).N═O)—R i or (ii) —CH(R d )—O—C(O)-T-(C(R e )(R f )) p -G-(C(R e )(R f )) p —N(N—(O − ).N ═O)—R i ; wherein T, R e , R f , p, G, R i , and R d are as defined herein; R 8 and R 9 are each independently amino, hydrogen, —CH 2 O—R j , or —O—R k ; R k is —C(O)—R d or R j ; wherein R d and R j are as defined herein; S 1 is: (1) —CH 2 —N(Z)—R 10 ; wherein Z is hydrogen, —(N(O − )N═O), or M; wherein M is as defined herein; R 10 is: (i) lower alkyl (ii) —(CH 2 ) p —O—(CH 2 ) a —C 6 H 5 ; wherein a is an integer from 1 to 4 and p is defined herein; wherein Z is as defined herein; R 11 is hydrogen, D, or M; with the proviso that R 11 must be D or M if neither R 8 or R 9 include D or M and Z is a hydrogen; and with the proviso that the compounds of Formula (II) must contain at least one —NO group or at least one —NO 2 group, and wherein the at least one —NO group or the at least one —NO 2 group is linked to the compounds of Formula (II) through an oxygen atom, a nitrogen atom or a sulfur atom.