Patent ID: 7696230

Claim:
Nitrooxyderivative compounds or salts thereof having the following general formula (I): A-(B) b0 -(T C -Y) c0 —NO 2 (I) wherein: c0 is an integer and is 0 or 1; b0 is an integer and is 0 or 1; A=R-T 1 -, wherein the precursors of A is an antipain drug selected from: lamotrigine, topiramate, tiagabine, zonisamide, amineptine, demexiptiline, desipramine, nortriptyline, opipramol and tianeptine, and wherein R is a radical of said antipain drug; T 1 =(CO) t or (X) t′ , wherein X=O, S, NR 1C , R 1C is H or a linear or branched alkyl, having from 1 to 5 carbon atoms, t and t′ are integers and equal to zero or 1, with the proviso that t=1 when t′=0; t=0 when t′=1; B=-T B -X 2 -T BI - wherein T B and T BI are equal or different; T B =(CO) when t=0, T B =X when t′=0, X being as above; T BI =(CO) tx or (X) txx , wherein tx and txx have the value of 0 or 1; with the proviso that tx=1 when txx=0; and tx=0 when txx=1; X is as above; X 2 , bivalent radical, is such that the corresponding precursor of B wherein the free valences of T B and of T BI are saturated each with OZ, with Z or with —N(Z I )(Z II ), being: Z=H, C 1 -C 10 ; Z I , Z II equal to or different have the values of Z as above, depending on that T B and/or T BI =CO or X, in function of the values of t, t′, tx and txx; the precursor compound of B as above defined being selected from the following classes of compounds: aminoacids, selected from the following: L-carnosine, anserine, selenocysteine, selenomethionine, penicillamine, N-acetylpenicillamine, cysteine, N-acetylcysteine, glutathione or esters thereof; hydroxyacids, selected from the following: gallic acid, ferulic acid, gentisic acid, citric acid, caffeic, dihydrocaffeic acid, p-cumaric acid, vanillic acid; and wherein when b0=c0=1, T C =(CO); when tx=0, T C =X, when txx=0, X being as above defined; when b0=0, T C =(CO); when t=0, T C =X; when t′=0, X being as above defined; when c0=0|tx=0, T BI =X=—O—; Y has one of the following meanings; wherein: nIX is an integer from 0 to 5; nIIX is an integer comprised from 1 and 5; R TIX , R TIX ′, R TIIX , R TIIX′ , equal to or different from each other are H or linear or branched C 1 -C 4 alkyl; Y 3 is a saturated, unsaturated or aromatic heterocyclic ring, having 5 or 6 atoms, containing from one to three heteroatoms, said heteroatoms being equal or different and selected from nitrogen, oxygen, sulphur; and Y 3 is selected from the group consisting of: or Y can be: Y 0 , selected from the following: an alkylenoxy group R′O wherein R′ is a linear or branched when possible C 1 -C 20 alkyl, or a cycloalkylene having from 5 to 7 carbon atoms, in the cycloalkylene ring one or more carbon atoms can be substituted by heteroatoms, the ring can have side chains of R′ type, R′ being as above; or Y is selected from one of the following groups: wherein nf′ is an integer from 1 to 6; wherein R 1f =H, CH 3 and nf is an integer from 1 to 6 ; Y AR , selected from: wherein n3 is an integer from 0 to 5 and n3′ is an integer from 1 to 3; or wherein n3 and n3′ have the above meaning.