Patent ID: 7223792

Claim:
An isolated and purified Annonaceous acetogenin compound having the structure of: a. muricin A having the formula of: said muricin A having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-15 and C-18 with one flanking hydroxyl in a threo conformation, two methylene groups of the mono-THF ring corresponding to a trans conformation, two hydroxyl groups at C-26 and C-27 as vicinal diol assigned as threo based, and the stereochemistry at C-34 on the γ-lactone fragment performed in (S)-configuration; b. muricin B having the formula of: said muricin B having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-15 and C-18 with one flanking hydroxyl in a trans/threo conformation, two methylene groups of the mono-THF ring corresponding to a trans conformation, two hydroxyl groups at C-26 and C-27 as vicinal diol assigned as threo based, and the stereochemistry at C-34 on the γ-lactone fragment performed in (S)-configuration; c. muricin C having the formula of: said muricin C having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-17 and C-20 with one flanking hydroxyl in a trans/threo or threo/trans conformation, two hydroxyl groups at C-24 and C-25 as vicinal diol assigned as threo based, and the stereochemistry at C-34 on the γ-lactone fragment performed in (S)-configuration; d. muricin D having the formula of: said muricin D having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-15 and C-18 with one flanking hydroxyl in a threo/trans conformation, two hydroxyl groups at C-22 and C-23 as vicinal diol assigned as threo based; e. muricin B having the formula of: said muricin E having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-12 and C-15 with one flanking hydroxyl in a threo/trans conformation, two hydroxyl groups at C-22 and C-23 as vicinal diol assigned as threo based; f. muricin F having the formula of: said muricin F having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-17 and C-20 with one flanking hydroxyl in a threo/trans conformation, two hydroxyl groups at C-27 and C-28 as vicinal diol assigned as threo based, and a double bond determined at C-24/C-25; or g. muricin G having the formula of: said muricin G having an α, β-unsaturated γ-lactone with a hydroxyl group at C-4, a mono-THF ring placed between C-16 and C-19 with one flanking hydroxyl in a threo/trans/threo conformation, one hydroxyl groups formed at C-10, a double bond determined at C-23/C-24, and the stereochemistry at C-34 on the γ-lactone fragment performed in (S)-configuration.