Patent ID: 7259182

Claim:
A compound of formula I: wherein: R 1 is the moiety: R 4 is hydrogen, halogen, C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, C 1 –C 3 perfluoroalkoxy, C 1 –C 3 alkylthio, C 1 –C 3 perfluoroalkylthio, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 7 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; X is O; R 5 is C 1 –C 8 alkyl, C 1 –C 3 perfluoroalkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, heteroaryl, —CH 2 -heteroaryl, phenyl, or arylalkyl where the alkyl chain is C 1 –C 8 , wherein the rings of the cycloalkyl, heteroaryl, phenyl, and aryl groups are optionally substituted by from 1 to 5 groups selected from halogen, C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, C 1 –C 3 perfluoroalkoxy, C 1 –C 3 alkylthio, C 1 –C 3 perfluoroalkylthio, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 7 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 2 is hydrogen, C 1 –C 6 alkyl, —CH 2 —C 3 –C 6 cycloalkyl, or C 1 –C 3 perfluoroalkyl, wherein the alkyl and cycloalkyl groups are optionally substituted by halogen, —CN, C 1 –C 6 alkoxy, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 7 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 3 is: (a) hydrogen, halogen, C 1 –C 8 alkyl, C 1 –C 8 alkenyl, C 1 –C 8 alkynyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, heteroaryl, or phenyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, and phenyl groups are optionally substituted by from 1 to 3 groups selected from halogen, C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, C 1 –C 3 perfluoroalkoxy, C 1 –C 3 alkylthio, C 1 –C 3 perfluoroalkylthio, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 7 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; or (b) the moiety X—R 6 ; R 6 is C 1 –C 8 alkyl, C 1 –C 8 alkenyl, C 1 –C 8 alkynyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, heteroaryl, phenyl, aryl-alkyl where the alkyl chain is C 1 –C 8 , CH 2 CH 2 -phenyl, or CH 2 CH 2 -napthyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, phenyl, and napthyl groups are optionally substituted by from 1 to 3 groups selected from halogen, C 1 –C 3 alkyl, C 1 –C 3 perfluoroalkyl, —O—C 1 –C 3 perfluoroalkyl, —S—C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, —OCHF 2 , —CN, —C(O)CH 3 , —CO 2 R 7 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; and R 7 is C 1 –C 6 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, or aryl-alkyl where the alkyl chain is C 1 —C 8 ; or a pharmaceutically acceptable salt or ester form thereof.