Patent ID: 8202891

Claim:
A compound having the formula IIc: where X − is an anion of a pharmaceutically acceptable acid; R 1 is selected from —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, —C 1-3 alkylene-SCH 3 , and —C 3-9 cycloalkyl; R 3 is selected from H and —C 0-1 alkylene-OH; or when R 1 is —C 3-9 cycloalkyl, R 3 can form a double bond with the carbon atom on the —C 3-9 cycloalkyl group; R 5 is selected from —C 1-5 alkyl and —C 0-1 alkyleneC 3-5 cycloalkyl; R 6 is selected from —C 1-3 alkyl, —C 1-2 alkyleneC 3-7 cycloalkyl, —C 0-4 alkylene-OH, —C 1-2 alkylene-C(O)O—C 1-4 alkyl, and —C 1-2 alkylene-C(O)NR 6a R 6b ; where R 6a and R 6b are independently selected from H and —C 1-4 alkyl; or R 6 is taken with R 5 to form —C 3-5 alkylene-; Z is selected from a bond, —O—, —S—, —S(O)—, —SO 2 —, —SO 2 —NR Z1 —, —NR Z1 —SO 2 —, —C(O)—, —OC(O)—, —C(O)O—, —NR Z1 C(O)—, —C(O)NR Z1 —, —NR Z2 —C(O)—NR Z3 —, —NR Z2 —C(S)—NR Z3 —, —CH(OH)—, and —C(═N—O—R Z4 )—; where R Z1 is selected from H and —C 1-4 alkyl; R Z2 and R Z3 are independently selected from H, —C 1-4 alkyl, and —C 3-6 cycloalkyl, or R Z2 and R Z3 are taken together to form —C 2-4 alkylene- or —C 2-3 alkenylene-; and R Z4 is selected from —C 1-4 alkyl and benzyl; each R group is independently selected from —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —C 3-6 cycloalkyl, cyano, halo, —OR a , —SR a , —S(O)R a , —S(O) 2 R a , and —NR b R c ; where each R a is independently selected from H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; and each R b and R c is independently selected from H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, and —C 3-6 cycloalkyl; each R Q group is independently selected from halo, —C 1-4 alkyl, —C 0-4 alkylene-OH, cyano, —C 0-2 alkylene-COOH, —C(O)O—C 1-4 alkyl, —O—C 1-4 alkyl, —S—C 1-4 alkyl, —NH—C(O)—C 1-4 alkyl, —N-di-C 1-4 alkyl, and —N + (O)O; wherein each alkyl, alkylene, alkenyl, alkenylene, alkynyl, and cycloalkyl group in R, R 3 , R 5 , R 6 , Z, and R Q , is optionally substituted with 1 to 5 fluoro atoms; and each —CH 2 — group in —(CH 2 ) 1-4 — is optionally substituted with 1 or 2 substituents independently selected from —C 1-2 alkyl, —OH, fluoro, and phenyl; and pharmaceutically acceptable salts thereof.