Patent ID: 7648979

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: A is C(O) or S(O) 2 ; R 1 is selected from the group consisting of: (1) lower alkyl, (2) lower alkoxy, (3) cycloalkyl, (4) lower cycloalkylalkyl, (5) lower halogenalkyl, (6) phenyl unsubstituted or substituted with one to three substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halogen, lower halogenalkyl and cyano, and (7) —NR 4 R 5 , wherein R 4 and R 5 independently from each other are selected from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl, lower halogenalkyl and lower phenylalkyl, or alternatively, R 4 and R 5 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring optionally containing a further heteroatom of nitrogen, oxygen or sulfur; R 2 is selected from the group consisting of: (1) hydrogen, (2) lower alkyl, (3) cycloalkyl, (4) lower cycloalkylalkyl, (5) lower hydroxyalkyl, (6) lower alkoxyalkyl, (7) lower halogenalkyl, (8) lower cyanoalkyl, (9) lower alkylsulfonyl, (10) lower alkanoyl, (11) phenylsulfonyl wherein the phenyl ring may be unsubstituted or substituted with one to three substituents independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower halogenalkoxy and lower hydroxyalkyl, (12) phenyl unsubstituted or substituted with one to three substituents independently selected from the group consisting of lower alkyl, halogen, cyano, morpholinyl, lower alkoxy, lower alkoxycarbonyl, lower halogenalkyl, lower halogenalkoxy, lower hydroxyalkyl, lower alkylsulfonyl and lower alkylsulfonylamino, (13) benzodioxolyl, (14) lower phenylalkyl, wherein the phenyl ring may be unsubstituted or substituted with one to three substituents independently selected from the group consisting of lower alkyl, halogen, cyano, morpholinyl, lower alkoxy, lower alkoxycarbonyl, lower halogenalkyl, lower halogenalkoxy, lower hydroxyalkyl, lower alkylsulfonyl and lower alkylsulfonylamino, and (15) heteroaryl unsubstituted or substituted with one or two substituents independently selected from the group consisting of lower alkyl, lower alkoxy, cyano, morpholinyl and halogen; R 3 is hydrogen, halogen or methyl; G is either G1 or G2: wherein: R 6 is lower alkyl, cycloalkyl, lower cycloalkylalkyl or a heterocyclic ring containing oxygen, and R 7 is hydrogen; or alternatively R 6 and R 7 together are —(CH 2 ) m —, wherein m is 3 or 4, and are bonded to each other to form a ring together with the carbon or nitrogen atom to which they are attached; n is 1 or 2; p is 1 or 2; R 8 is hydrogen; R 9 and R 10 independently from each other are hydrogen or —NR 11 R 12 ; and R 11 and R 12 independently from each other are lower alkyl or together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated heterocyclic ring optionally containing a further heteroatom of nitrogen, oxygen or sulfur.