Patent ID: 7060870

Claim:
A transgenic mouse whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter operatively linked to a DNA sequence which encodes amyloid-beta peptide binding alcohol dehydrogenase (ABAD), and (b) a nerve tissue specific promoter operatively linked to a DNA sequence encoding each of mutant human amyloid precursor proteins hAPP695, hAPP751, and hAPP770 bearing mutations linked to familial Alzheimer's disease in humans, wherein said mouse exhibits at least one phenotype from the group consisting of: reduced basal synaptic transmission; inhibited synaptic plasticity; increased neuronal stress; elevated 4-hydroxynonenal in cerebral cortex; increased heme oxygenase type I in cerebral cortex; decreased microtubule-associated protein 2 in cerebral cortex; and increased levels of activated caspase 3 antigen in cortical neurons.