Patent ID: 8637543

Claim:
A compound represented by formula (IIB) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof: wherein E represents (methyl)methylene; Q represents N—R 8 ; M represents the residue of piperazin-1-yl, optionally substituted by one or more substituents independently selected from oxo, C 2-6 alkylcarbonyl, hydroxy(C 1-6 )alkylcarbonyl, di(C 1-6 )alkylamino(C 1-6 )alkylcarbonyl, carboxy, carboxy(C 1-6 )alkyl, C 2-6 alkoxycarbonyl, hydroxy(C 1-6 )alkylcarbonylamino, (C 3-7 )cycloalkylcarbonylamino, aminocarbonyl and C 1-6 alkylaminocarbonyl; R 1 and R 2 independently represent hydrogen, halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, aryl(C 1-6 )alkyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkyl-amino, C 2-6 alkylcarbonylamino, C 2-6 alkoxycarbonylamino, C 1-6 alkylsulfonylamino, formyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di(C 1-6 )alkylaminocarbonyl, aminosulfonyl, C 1-6 alkylaminosulfonyl or di(C 1-6 )alkylaminosulfonyl; and R 5 and R 6 independently represent C 1-6 alkyl, aryl, aryl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; or hydrogen, halogen, trifluoromethyl, —OR a , —SR a , —SOR a , —SO 2 R a , —NR b R c , —NR c COR d , —NR c CO 2 R d , —NR c SO 2 R e , —COR d , —CO 2 R d , —CONR b R c or —SO 2 NR b R c ; or R 5 and R 6 , when taken together with the carbon atoms to which they are attached, represent optionally substituted C 5-7 cycloalkenyl; R a represents C 1-6 alkyl, difluoromethyl or trifluoromethyl; R b represents hydrogen or trifluoromethyl; or C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkyl-(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; R c represents hydrogen, C 1-6 alkyl or C 3-7 cycloalkyl; R d represents hydrogen or C 1-6 alkyl; and R e represents C 1-6 alkyl.