Patent ID: 8252338

Claim:
A synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide, wherein: the lipid moiety forms a particle of about 10-30 nm in size, and the synthetic chimeric peptide comprises an amphipathic a-helix and an LDL receptor binding domain, wherein the LDL receptor binding domain consists of the following amino acid sequence: (R 1 ) x -Arg-Leu-Thr-Arg-Lys-Arg-Gly-Leu-Lys-(R 2 ) y in which R 1 is an amino acid sequence from 1 to 40 amino acids wherein each amino acid is independently selected from the group consisting of naturally occurring amino acids and amino acid mimetics; R 2 is an amino acid sequence from 1 to 40 amino acids wherein each amino acid is independently selected from the group consisting of naturally occuring amino acids and amino acid mimetics; and x and y are independently selected and are equal to zero or one (SEQ ID NO:9).