Patent ID: 8877815

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof wherein: R 3 and R 4 are H or R 3 and R 4 together with the carbon atoms to which they are attached form a phenyl ring; n is 0 or 1; R 1 is phenyl or pyridinyl each of which is optionally substituted by one or more substituents selected from halo, C 1-6 alkyl, halo-C 1-6 alkyl, cyano, C 1-6 alkoxy, hydroxy and NR c R d ; wherein R c and R d are independently H or C 1-6 alkyl, R 2 is (CH 2 ) p C(O)X 1 , or (CH 2 ) s -heteroaryl; wherein heteroaryl is a mono or bicyclic heteroaryl ring containing from 5-10 ring members selected from carbon atoms and 1 to 5 heteroatoms, and each heteroatom is independently selected from O, N or S wherein S and N may be oxidized to various oxidation states and the hereroaryl is optionally substituted with one or more substituents independently selected from halo, C 1-6 alkyl, halo-C 1-6 alkyl, cyano, hydroxy, C 1-6 alkoxy, carboxy and C(O)O—C 1-6 alkyl; R 5 is H, C 1-6 alkyl or C 6-10 aryl-C 1-6 alkyl; p is 0 or 1; s is 0, 1, 2, 3 or 4; m is 1; X and X 1 are independently OH, O—C 1-6 alkyl, O-benzyl or NR a R b wherein R a and R b are independently H, C 1-6 alkyl optionally substituted with one or more substituents independently selected from halo, hydroxy, C 1-6 alkoxy and carboxy; or R a and R b together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclyl optionally substituted with one or more substituents independently selected from C 1-6 alkyl, halo, hydroxy, C 1-6 alkoxy, carboxy, C(O)O—C 1-6 alkyl and C(O)O-benzyl; and B is C(O)NH or NHC(O), with the proviso that the compound is not 4-(bisphenyl-4-yl)-3-(1-carboxymethyl)cyclopentanecarboxamido)butanoic acid, 4-([1,1′-biphenyl]-4-yl)-3-(1-(2-(benzyloxy)-2-oxoethyl)cyclopentanecarboxamido)butanoic acid or tert-butyl 4-([1,1′-biphenyl]-4-yl)-3-(1-(2-(benzyloxy)-2-oxoethyl)cyclopentanecarboxamido)butanoate.