Patent ID: 7160878

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein L is carbonyl or methylene and Q (showing L at its point of attachment) is a residue of formula Q A , in which A 3 , A 4 , A 5 and A 6 , together with the two carbons to which they are attached, complete a substituted benzene in which A 3 is CR 3 , A 4 is CR 4 , A 5 is CR 5 , and A 6 is CR 6 ; wherein R 3 is hydrogen, fluoro, chloro, methyl, methoxy, hydroxy or carboxy; one of R 4 and R 5 is hydrogen, (1–4C)alkyl, halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxymethyl, (1–3C)acyl, R f O—, R f O 2 C—, R f O 2 C—CH 2 —, R f O 2 C—CH 2 —O—, methylthio or R g NH—; the other of R 4 and R 5 is hydrogen, halo or methyl; and R 6 is hydrogen, fluoro, chloro, methyl or methoxy; in which R f is hydrogen, (1–4C)alkyl or benzyl; R g is hydrogen, (1–3C)acyl, trifluoroacetyl, methoxyacetyl, or R h SO h — (wherein h is 1 or 2); and R h is (1–4C)alkyl, trifluoromethyl, phenyl, amino, methylamino or dimethylamino; or A 3 , A 4 , A 5 and A 6 , together with the two carbons to which they are attached, complete a substituted heteroaromatic ring in which one of A 3 , A 4 , A 5 and A 6 is N, and each of the others is CR 3 , CR 4 , CR 5 or CR 6 , respectively; wherein each of R 3 , R 4 , R 5 and R 6 is independently hydrogen or methyl, or one of R 3 , R 4 , R 5 and R 6 attached to a carbon which is not bonded to an N-atom is chloro and the others are hydrogen; R 1 is 2-pyridinyl (which may bear a methyl, methoxy, methylthio, fluoro or chloro substituent at the 5-position), or R 1 is 3-pyridinyl (which may bear a methyl, fluoro or chloro substituent at the 6-position), or R 1 is phenyl (which may bear one, two or three substituents at the 3-, 4- or 5-position(s) independently selected from halo, cyano, carbamoyl, methyl, methoxy, difluoromethoxy, hydroxymethyl, formyl, vinyl, amino, hydroxy and 3,4-methylenedioxy; and in addition the phenyl may bear a 2-chloro or 2-fluoro substituent), or R 1 is 6-indolyl (which may bear a chloro or methyl substituent at the 3-position); or L is carbonyl and Q (showing L at its point of attachment) is a residue of formula Q B , wherein: Q 1 is phenyl, benzo[b]thiophen-2-yl or naphthalen-2-yl any of which may bear one or more halo, trifluoromethyl, methoxy or methyl substituents; L 1 is a direct bond, methylene, ethylene or ethen-1,2-diyl; one or two of X 1 , X 2 , X 3 and X 4 is N; and each of the others of X 1 , X 2 , X 3 and X 4 is CH; and R is hydrogen, (1–3C)alkyl, (1–3C)acyl, acetyloxyacetyl, aminoacetyl, hydroxyacetyl, {(1–4C)alkoxy}carbonyl, {(1–4C)alkoxy}carbonylmethyl, R a R b N—CO— or R j SO j —, wherein each of R a and R b is independently hydrogen or (1–3C)alkyl, or R a R b N— is 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or 4-thiomorpholinyl; j is 1 or 2; and R j is (1–4C)alkyl, trifluoromethyl, amino, methylamino or dimethylamino.