Patent ID: 8278301

Claim:
A method of treating irritable bowel syndrome, emesis, or post-operative nausea or vomiting, which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula wherein R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen, halogen, amino, alkylamino, dialkylamino, acylamino, morpholinyl, —O-loweralkyl, hydroxy, loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl and hydroxyloweralkyl; R 4 is a residue selected from the group consisting of: (i) a saturated nitrogen heterocycle or methyl-substituted saturated nitrogen heterocycle, in which said nitrogen is tertiary, said heterocycle containing at least one 5 or 6-membered ring; and (ii) an imidazolylalkyl residue wherein the imidazole of said imidazolylalkyl is optionally substituted with up to three groups chosen from halogen, (C 1 -C 4 )alkyl, substituted (C 1 -C 4 )alkyl and NH 2 ; and R 10 is selected from the group consisting of (i) hydrogen; (ii) (C 1 -C 10 )alkyl; (iii) substituted (C 1 -C 10 )alkyl; (iv) saturated C-attached heterocyclyl; and (v) substituted, saturated C-attached heterocyclyl.