Patent ID: 8138195

Claim:
A compound of formula (I): wherein A is an optionally substituted purinyl ring system; X is C(R b ) 2 ; Y is null or NH; R 1 and R 2 , independently, are selected from the group consisting of hydrogen, halo, NO 2 , CF 3 , and optionally substituted C 1-6 alkyl, OR a , N(R a ) 2 , OC 2-4 alkyleneOR a , and NR a C 1-4 alkyleneN(R a ) 2 ; R 3 is selected from the group consisting of optionally substituted, C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, C 1-4 alkylenecycloalkyl, C 2-6 alkenyl, C 1-3 alkylenearyl, arylC 1-3 alkyl, C(═O)R a , aryl, heteroaryl, C 1-4 alkylenearyl substituted with one or more of SO 2 N(R a ) 2 , N(R a ) 2 , C(═O)OR a , NR a SO 2 CF 3 , C(═O)R a , OR a , C 1-4 alkyleneN(R a ) 2 , and OC 1-4 alkyleneN(R a ) 2 , C 1-4 alkyleneHet, C 1-4 alkyleneOR a , C 1-4 alkyleneOC 1-4 alkyleneOR a , and C 1-4 alkyleneN (R a ) 2 ; wherein the optional substituents for R 3 are selected from one to three substituents selected from the group consisting of halo, OR a , C 1-6 alkyl, aryl, heteroaryl, NO 2 , N(R a ) 2 , NR a SO 2 CF 3 , NR a (C═O)R a , C(═O)OR a , N(R a )C 1-4 alkylene (R a ) 2 , SO 2 N(R a ) 2 , CN, C(═O)R a , C 1-4 alkyleneN(R a ) 2 , OC 1-4 alkyleneC═CR a , OC 1-4 alkyleneC(O)N(R a ) 2 , OC 1-4 alkylenearyl, OC 1-4 alkyleneheteroaryl, OC 1-4 alkyleneHet, OC 1-4 alkyleneN(R a ) 2 , and N(R a )C 1-4 alkyleneN(R a ) 2 ; each R a is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 heterocycloalkyl, C 1-3 alkyleneN(R c ) 2 , aryl, arylC 1-3 alkyl, C 1-3 alkylenearyl, heteroaryl, heteroarylC 1-3 alkyl, and C 1-3 alkyleneheteroaryl; or two R a groups are taken together to form a 5- or 6-membered ring, optionally containing at least one heteroatom; each R b is independently selected from the group consisting of hydrogen, C 1-6 alkyl, heteroC 1-3 alkyl, C 1-3 alkyleneheteroC 1-3 alkyl, arylheteroC 1-3 alkyl, aryl, heteroaryl, arylC 1-3 alkyl, heteroarylC 1-3 alkyl, C 1-3 alkylenearyl, and C 1-3 alkyleneheteroaryl; each R c is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, aryl, and heteroaryl; Het is a 5- or 6-membered heterocyclic ring, saturated or partially or fully unsaturated, containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, and optionally substituted with C 1-4 alkyl or C(═O)OR a ; or pharmaceutically acceptable salts thereof.