Patent ID: 7947273

Claim:
An isolated specific binding member for human IL-13, comprising an antibody antigen-binding domain site which is composed of a human antibody VH domain and a human antibody VL domain and which comprises a set of CDRs, HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein the VH domain comprises HCDR1, HCDR2 and HCDR3 and the VL domain comprises LCDR1, LCDR2 and LCDR3, wherein HCDR1 is of amino acid sequence which has the formula HX 1 HX 2 G HX 3 S (SEQ ID NO: 176) wherein HX 1 is selected from the group consisting of N, Q, D, L, G and E, HX 2 is selected from the group consisting of Y and T, HX 3 is selected from the group consisting of V, I, F and L, HCDR2 is of amino acid sequence which has the formula (SEQ ID NO: 177) W I HX 4 HX 5 HX 6 HX 7 G HX 8 T HX 9 Y HX 10 HX 11 HX 12 F HX 13 HX 14 wherein HX 4 is selected from the group consisting of S, D, N, A, R, G and E, HX 5 is selected from the group consisting of A, D, G, T, P, N and Y, HX 6 is selected from the group consisting of N, D, L, A, P, T, S, I and R, HX 7 is selected from the group consisting of N, S, T, D, G, K and I, HX 8 is selected from the group consisting of D, T, E, Q, L, Y, N, V, A, M and G, HX 9 is selected from the group consisting of N, I, L, Q, S, M, H, D and K, HX 10 is selected from the group consisting of G and R, HX 11 is selected from the group consisting of Q and R, HX 12 is selected from the group consisting of E, K and G, HX 13 is selected from the group consisting of Q and R, HX 14 is selected from the group consisting of G and K, HCDR3 is of amino acid sequence which has the formula (SEQ ID NO: 178) D HX 15 HX 16 HX 17 HX 18 W A R W HX 19 F HX 20 L wherein HX 15 is selected from the group consisting of S, R and D, HX 16 is selected from the group consisting of S, N, D, T and P, HX 17 is selected from the group consisting of S and R, HX 18 is selected from the group consisting of S, N, A, I, R, P and K, HX 19 is selected from the group consisting of F and Y, HX 20 is selected from the group consisting of D and Y, LCDR1 is of amino acid sequence which has the formula G G LX 1 LX 2 LX 3 G LX 4 LX 5 L V H (SEQ ID NO: 179) wherein LX 1 is selected from the group consisting of N, D and S, LX 2 is selected from the group consisting of N, I, L, M, C, V, K, Y, F, R, T, S, A, H and G, LX 3 is selected from the group consisting of I and V, LX 4 is selected from the group consisting of S and G, LX 5 is selected from the group consisting of K and R, LCDR2 is of amino acid sequence which has the formula D D G D R P LX 6 (SEQ ID NO: 180) wherein LX 6 is selected from the group consisting of S and T, LCDR3 is of amino acid sequence which has the formula Q V W D T G S LX 7 P V LX 8 (SEQ ID NO: 181) wherein LX 7 is selected from the group consisting of D and N, LX 8 is selected from the group consisting of V and I.