Patent ID: 7314878

Claim:
A piperazine benzothiazole compound having formula I as well as its tautomers, its geometrical isomers, its optically active forms as an enantiomer, a diastereomer and as a racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from the group comprising or consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkyl aryl, heteroaryl, C 1 -C 6 -alkyl heteroaryl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkenyl aryl, C 2 -C 6 -alkenyl heteroaryl, C 2 -C 6 -alkynyl, C 2 -C 6 -alkynyl aryl, C 2 -C 6 -alkynyl heteroaryl, C 3 -C 8 -cycloalkyl, heterocycloalkyl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, C 1 -C 6 -alkyl carboxy, acyl, C 1 -C 6 -alkyl acyl, acyloxy, C 1 -C 6 -alkyl acyloxy, C 1 -C 6 -alkyl alkoxy, alkoxycarbonyl, C 1 -C 6 -alkyl alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkyl aminocarbonyl, acylamino, C 1 -C 6 -alkyl acylamino, ureido, C 1 -C 6 -alkyl ureido, amino, C 1 -C 6 -alkyl amino, sulfonyloxy, C 1 -C 6 -alkyl sulfonyloxy, sulfonyl, C 1 -C 6 -alkyl sulfonyl, sulfinyl, C 1 -C 6 -alkyl sulfinyl, sulfanyl, C 1 -C 6 -alkyl sulfanyl, sulfonylamino, and C 1 -C 6 -alkyl sulfonylamino; R 1 is selected from the group comprising or consisting of H, halogen, cyano, nitro, amino, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkyl-aryl, aryl or heteroaryl, C 1 -C 6 -alkyl-heteroaryl, -C(O)-OR 2 , -C(O)-R 2 , -C(O)-NR 2 R 2′ , and -(SO 2 )R 2 , with R 2 and R 2′ being independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, heteroaryl, C 1 -C 6 -alkyl aryl, C 1 C 6 -alkyl heteroaryl and combinations mixtures thereof; and n is an integer from 0 to 3.