Patent ID: 7381424

Claim:
A dosage form for oral administration consisting of: a compressed homogeneous mixture comprising: a pharmacologically-active substance; and a hydrostatic couple consisting of: a) at least one crossliniked hydrodynamic fluid-imbibing polymer selected from the group consisting of: i) an acrylic-acid polymer cross-linked with allylsucrose or allylpentaerythritol; ii) one or more high amylose starches cross-linked by epichiorhydrin, phosphorous oxychloride (POCl 3 ), or sodium trimetaphosphate; iii) a crosslinked polylglucan; iv) a crosslinked polyethylenimine; v) a crosslinked polyallylamine, and vi) combinations thereof; and b) at least one crosslinked hydrostatic pressure-modulating agent selected from the group consisting of: i) a homopolymer of cross-linked N-vinyl-2-pyrollidone; ii) a rapidly expanding cross-linked cellulose derivative selected from the group consisting of cross-linked carboxymethyl cellulose, sodium starch glycolate, and combinations thereof; and iii) combinations thereof.