Patent ID: 7884085

Claim:
A composition that comprises microspheres comprising oligonucleotides for treatment of type 1 diabetes, wherein said microspheres contain a first antisense sequence that targets a primary transcript of CD40, a second antisense sequence that targets a primary transcript of CD80, and a third antisense sequence that targets a primary transcript of CD86, wherein each of said first, second and third oligonucleotides reduces or suppresses in vivo expression of CD40, CD80 and CD86 respectively, and wherein said oligonucleotides comprise greater than about 30 weight percent of the microspheres, based on the total weight of the microspheres, said microspheres having an average particle size of not greater than about 50 microns and at least 0.2 to 8 microns, and said microspheres, when administered, treat type 1 diabetes.