Patent ID: 8871757

Claim:
A compound according to Formula (I): any optical isomer, diastereomer, or enantiomer of Formula I or a physiologically acceptable salt or solvate thereof, wherein R 1 is an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, R 7 is hydrogen, C 1 -C 4 alkyl, cyano, or R 1 and R 7 combine to form a ring of at least three and at most eight member atoms, R 2 , and R 3 are, independently, hydrogen, hydroxyl, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, amino, nitro, cyano, C 1 -C 4 carbonyl, C 1 -C 4 carbonylamino, C 1 -C 4 alkoxy, C 1 -C 4 sulfonyl, C 1 -C 4 sulfonylamino, C 1 -C 4 thioalkyl, C 1 -C 4 carboxyl, cycloalkyl, heterocycloalkyl, aryl, C 1 -C 4 alkyl aryl, heteroaryl, or C 1 -C 4 alkyl heteroaryl; or R 2 and R 3 combine to form a ring of at least five and at most eight member atoms, X is a carbonyl group, a sulfone group, thiocarbonyl or methylene, and R 4 and R 5 are independently, halogen, hydrogen, hydroxy, alkyl, alkoxy, amino, carbonyl, cycloalkyl, heterocycloalkyl, aryl, C 1 -C 4 alkyl aryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, alkenyl, alkynyl, nitro, cyano, C 1 -C 4 carbonylamino, C 1 -C 4 sulfonyl, C 1 -C 4 sulfonylamino, C 1 -C 4 thioalkyl or C 1 -C 4 carboxyl.