Patent ID: 7125840

Claim:
A compound of the Formula I wherein: R1 is NHR10 or C 1 –C 6 alkylNHR10; R10 selected from the group consisting of hydrogen, C 1 –C 6 alkyl, C 1 –C 6 alkyl(OH), C 1 –C 6 alkylidenyl(OH)R11, and an amino protecting group; R11 is selected from the group consisting of C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 1 –C 6 alkyl(O)C 1 –C 6 alkyl, C(O)O—C 1 –C 6 alkyl, aryl, and C 1 –C 6 alkylaryl; R2 is selected from hydrogen, C 1 –C 6 alkyl, aryl, and C 1 –C 6 alkylaryl; R3 is selected from the group consisting of optionally substituted aryl, C 1 –C 6 alkylaryl, C 1 –C 6 alkyl(O)—C 1 –C 6 alkylaryl, C 3 –C 8 cycloalkyl, (C 1 –C 6 alkyl) C 3 –C 8 cycloalkyl, indolyl, indolinyl, (C 1 –C 6 alkyl) indolyl; R4 is hydrogen, C 1 –C 6 alkyl, aryl, C 1 –C 6 alkylaryl, C 2 –C 6 alkenyl; R5 is selected from hydrogen, C 1 –C 6 alkyl, aryl, and C 1 –C 6 alkylaryl; W is —CH 2 C 6 H 4 — or —(CH 2 ) m , where m is a number selected from 1 to 4; R6 and R7 are independently selected from the group consisting of hydrogen, C 1 –C 6 alkyl, C 2 –C 6 alkenyl, or R6 and R7 together with the carbon atom to which they are attached may form a carbocyclic ring of up to 8 atoms which is optionally partly unsaturated; R8 is selected from the group consisting of hydrogen, C 1 –C 6 alkyl, aryl, and C 1 –C 6 alkylaryl; R9 is selected from the group consisting of hydrogen, C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, C 3 –C 8 cycloalkyl, C 3 –C 8 cycloalkenyl, optionally substituted aryl, optionally substituted —O-aryl, optionally substituted —N-aryl, optionally substituted —S-aryl, -aryl-aryl(K1)(K2), —O-aryl-aryl(K1)(K2), —N-aryl-aryl(K1)(K2), —S-aryl-aryl(K1)(K2), —O—C 1 –C 6 alkyl, and C 1 –C 6 alkylaryl, wherein K1 is halo or —CF 3 and K2 is hydrogen, halo or —CF 3 ; and Q is —S(O) 2 — or —C(O)—; or a pharmaceutically acceptable salt thereof.