Patent ID: 8431110

Claim:
A method of identifying a compound as an inhibitor of a protein, wherein said compound has improved cellular specificity as compared to a first compound that is an inhibitor of the protein and modulates a corresponding phenoresponse comprising: a) measuring the modulation of the phenoresponse of a test cell treated with the first compound; b) measuring the modulation of the phenoresponse of a control cell treated with the first compound; c) measuring the modulation of the phenoresponse of the test cell treated with a test compound; d) measuring the modulation of the phenoresponse of the control cell treated with the test compound; e) determining the cellular specificity gap of the first compound and the cellular specificity gap of the test compound; and f) identifying the test compound as having improved cellular specificity if the cellular specificity gap of the test compound is greater than the cellular specificity gap of the first compound.