Patent ID: 7452997

Claim:
A compound having a structure according to formula I: wherein X 1 is absent, or is lower alkylene; R 1 is selected from the group consisting of aryl, C 3 -C 12 cycloalkyl, or heterocyclyl, any of which are optionally substituted at one or more positions by halogen, lower alkyl, hydroxy or lower alkoxy; R 4 is CH-aryl wherein aryl is optionally substituted at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen; or CH-heterocyclyl wherein heterocyclyl is optionally substituted at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen; R 6 is absent; R 6a is hydrogen; lower alkyl; or aryl optionally substituted by one or more of halogen, hydroxy, lower alkoxy, carboxy or alkoxycarbonyl; R 9 is aryl optionally substituted by one or more hydroxy, halogen, —NH(R 6a ), —SO 2 —NH(R 6a ), lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy; C 3 -C 12 cycloalkyl optionally substituted by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy, arylalkoxy, or lower alkylene; or heterocyclyl optionally substituted by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy R 9a is hydrogen or lower alkyl; Z 2 is absent; or is lower alkylene optionally substituted at one or more positions by aryl, cycloalkyl, halogen, hydroxy, lower alkyl, lower alkoxy, carboxy, alkoxycarbonyl or aryl; or a pharmaceutically acceptable salt or polymorph thereof.