Patent ID: 7381749

Claim:
A compound having structural formula (I), or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein: G 1 is optionally substituted phenyl; G 2 is selected from the group consisting of an N-sulfonamide having structure (II), an S-sulfonamide having structure (III), an amide of the form —NR 3 C(O)—, and an amide of the form —C(O)NR 3 —: G 3 is selected from the group consisting of optionally substituted phenyl and optionally substituted alkyl; R 1 and R 2 are each independently selected from the group consisting of hydrogen, lower alkyl, halogen and perhaloalkyl, or R 1 and R 2 taken together form optionally substituted cycloalkyl; R 3 and R 4 are each independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted aryl, and optionally substituted alkaryl and a structural element known to confer aqueous solubility; G 4 is selected from the group consisting of optionally substituted acyl, optionally substituted alkyl thiol, and —P(O)(OR 5 ) 2 or —P(O)(OH) 2 ; and each R 5 is independently selected from the group consisting of hydrogen, alkyl, aryl, and arylalkyl.