Patent ID: 8734800

Claim:
A method of inhibiting biological activity of interleukin-6 receptor (IL-6R) with an antibody subtype against IL-6R, comprising contacting the IL-6R with the antibody subtype, wherein the antibody subtype comprises a heavy chain that has amino acids 1-448 of the amino acid sequence set forth in SEQ ID NO: 1 in which an N-terminal glutamine (Gln) is pyroglutamylated, a heavy chain that has amino acids 1-447 of the amino acid sequence set forth in SEQ ID NO: 1 in which an N-terminal glutamine (Gln) is pyroglutamylated and a C-terminal that is Pro-NH 2 , and a light chain that has the amino acid sequence set forth in SEQ ID NO: 2.