Patent ID: 7264608

Claim:
A manual closed blood collection system comprising a primary container sized and configured to hold a unit of whole blood drawn from an individual donor for centrifugal separation, a platelet unit container downstream of said primary container and sized and configured to hold a platelet concentrate and a first volume of plasma centrifugally separated from the unit of whole blood, a plasma unit container sized and configured to hold a second volume of plasma centrifugally separated from the unit of whole blood, an auxiliary container downstream of said platelet container, a synthetic platelet additive solution carried within the auxiliary container in an at least an amount sufficient for mixing with the platelet concentrate and first volume of plasma to achieve a predetermined ratio of additive solution and plasma and provide a platelet concentrate mixture conditioned for a pathogen inactivation treatment, the synthetic platelet additive solution comprising an aqueous solution comprising sodium chloride, sodium citrate, sodium acetate, and sodium phosphate for conditioning the platelet concentrate mixture for pathogen inactivation in the presence of a selected pathogen inactivating compound selected from a group comprising psoralens, methylene blue, dimethyl-methylene blue, riboflavin, or PEN 110 , or combinations thereof, tubing integrally coupling the primary container, the platelet unit container, the plasma unit container, and the auxiliary container to form a sterile, closed blood processing system, an in-line filter adapted to remove leukocytes from separated platelets, a filter by-pass branch extending around said filter; and a one-way valve provided in said by-pass branch; wherein said filter and one-way valve are located between said platelet container and said auxiliary container and allow for direct flow between said platelet and auxiliary containers.