Patent ID: 8026243

Claim:
A compound of Formula I: in which: Z is N and Y is CH; R 1 is C 1-4 alkoxy; R 2 is selected from cyano, C 1-4 alkoxy, —C(O)NR 7 R 8 , —NR 7 C(O)R 8 , —NR 7 S(O) 2 R 8 , —S(O) 2 NR 7 R 8 , —NR 7 R 8 , —C(O)OR 8 , —OC(O)R 8 , —C(O)NR 7 OR 8 and a saturated, unsaturated or partially saturated monocyclic ring containing 5 to 7 ring members selected from C, O, N and S; wherein R 7 is selected from hydrogen and C 1-4 alkyl; and R 8 is selected from hydrogen, C 1-4 alkyl and C 3-12 cycloalkyl, R 3 is selected from hydrogen, halo, C 1-4 alkyl and C 1-4 alkoxy; R 4a is selected from halo and C 1-4 alkyl; R 4b is selected from hydrogen and C 1-4 alkyl; R 5 is hydrogen and C 1-4 alkyl; R 6 is selected from hydrogen, —X 1 R 9 and X 1 NR 10 R 11 ; wherein each X 1 is independently selected from a bond and C 1-4 alkylene; R 9 is selected from C 6-10 aryl, a monocyclic ring containing 5 to 7 ring members selected from C, O, N and S, and a bridged or fused bicyclic ring system containing 8 to 14 members selected from C, O, N and S; wherein said monocyclic and bridged or fused bicyclic rings of R 9 can be saturated, unsaturated or partially unsaturated; R 10 and R 11 are independently selected from hydrogen and C 1-4 alkyl; wherein said aryl, monocyclic or bicyclic rings of R 9 can be optionally substituted with a group selected from C 1-4 alkyl, —X 2 R 12 , and —OX 2 NR 13 R 14 ; wherein each X 2 is independently selected from a bond and C 1-4 alkylene; R 13 and R 14 are independently selected from hydrogen and C 1-4 alkyl; R 12 is selected from a monocyclic ring containing 5 to 7 ring members selected from C, O, N and S optionally substituted with up to 3 groups selected from C 1-4 alkyl, —X 3 C(O)NR 15 R 16 , —X 3 OR 16 , —X 3 C(O)X 3 OR 15 , —X 3 C(O)R 15 and —X 3 NR 15 R 16 ; wherein said monocyclic ring of R 12 can be saturated, unsaturated or partially unsaturated; wherein each X 3 is independently selected from a bond and C 1-4 alkylene; each R 15 and R 16 is independently selected from hydrogen and C 1-4 alkyl; wherein any alkyl substituents of R 9 can optionally substituted with up to 3 hydroxyl groups; or a pharmaceutically acceptable salt thereof.