Patent ID: 8481712

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: B is: L is CH or N; E is N or CR 5 ; W is O or S; R 1 is C 2-4 alkenyl, C 2-4 alkynyl, or C 1-4 alkyl optionally substituted with amino, hydroxy, or 1 to 3 fluorine atoms; R 3 is hydroxy or C 1-4 alkoxy; and R 2 is selected from the group consisting of halogen, C 1-4 alkyl, optionally substituted with 1 to 3 fluorine atoms, C 1-10 alkoxy, optionally substituted with C 1-3 alkoxy or 1 to 3 fluorine atoms, C 2-6 alkenyloxy, C 1-4 alkylthio, C 1-8 alkylcarbonyloxy, aryloxycarbonyl, azido, amino, C 1-4 alkylamino, and di(C 1-4 alkyl)amino; R 4 and R 6 are each independently H, OH, SH, NH 2 , C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 3-6 cycloalkylamino, halogen, C 1-4 alkyl, C 1-4 alkoxy, or CF 3 ; R 5 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 alkylamino, CF 3 , or halogen; R 12 and R 13 are each independently hydrogen or methyl.