Patent ID: 7026510

Claim:
A (R)-2-aryl-propionamide compound of formula (I): wherein Ar represents a substituted or non-substituted aryl group; R represents hydrogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl, C 2 –C 4 alkynyl, optionally substituted by a CO 2 R 4 group, wherein R 4 represents hydrogen or a linear or branched C 1 –C 6 alkyl group or a linear or branched C 2 –C 6 alkenyl group; X represents: linear or branched C 1 –C 6 alkylene, C 4 –C 6 alkenylene, C 4 –C 6 alkynylene, optionally substituted by a CO 2 R 4 group or by a CONHR 5 group wherein R 5 represents hydrogen, linear or branched C 2 –C 6 alkyl or an OR 4 group, R 4 being defined as above; phenyl or a phenylmethylene group of formula: a (CH 2 ) m —B—(CH 2 ) n , group, optionally substituted by a CO 2 R 4 or CONHR 5 group, as defined above, wherein B is an oxygen or sulfur atom, m is zero or an integer from 2 to 3 and n is an integer from 2 to 3; or B is a CO, SO or CONH group, m is an integer from 1 to 3 and n is an integer from 2 to 3; or X together with the nitrogen atom to which it is bound and with the R 1 group forms a nitrogen containing 3–7 membered heterocyclic monocyclic or polycyclic ring; R 1 , R 2 and R 3 are independently linear or branched C 1 –C 6 alkyl, optionally substituted by an oxygen or sulfur atom, a C 3 –C 7 cycloalkyl, C 3 –C 6 alkenyl, C 3 –C 6 -alkynyl, aryl, aryl-C 1 –C 3 -alkyl, hydroxy-C 2 –C 3 -alkyl group; or R 1 and R 2 together with the N atom to which they are bound, form a nitrogen containing 3–7 membered heterocyclic ring of formula (II) and R 3 independently has the meanings as defined above, wherein Y represents a single bond, a methylene group, an oxygen atom, a nitrogen atom or a sulfur atom and p represents an integer from 0 to 3; Z − represents a pharmaceutically acceptable counter-ion of quaternary ammonium salts, with the proviso that when Ar is biphenyl, R 2 and R 3 are not ethyl.