Patent ID: 7807697

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: X is NH or N(alkyl); Y, and Y′ are each independently selected from the group consisting of CH and CF; Z is N; one of R 1 and R 2 is heteroaryl; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halo, cyano, and thioalkoxy; R 3 is absent when Z is N; R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the structure (a): R 7 , R 8 , R 9 , and R 10 are each independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, and alkyl; or one of the pair R 7 and R 8 or the pair R 9 and R 10 is taken together to form a C 3 -C 6 ring, wherein 0, 1, or 2 heteroatoms selected from O, N, or S replace a carbon atom in the ring; R 11 and R 12 are each independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, alkyl, and fluoro; R 13 and R 14 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, and fluoro; L is —[C(R 15 )(R 16 )] n —; R 15 and R 16 at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkoxy, and fluoro; m is 1; and n is an integer from 2-3.