Patent ID: 8293748

Claim:
A compound of formula (I) wherein R 1 is C 1-6 alkyl optionally substituted by a hydroxyl group; R 2 is H or C 1-6 alkyl optionally substituted by a hydroxyl group; R 3 is H, C 1-6 alkyl or C 0-3 alkylC 3-6 cycloalkyl, Ar is a naphthyl or a phenyl ring either of which may be optionally substituted by one or more groups independently selected from C 1-6 alkyl, C 1-6 alkoxy, amino, C 1-4 mono or di-alkyl amino; L is a saturated or unsaturated branched or unbranched C 1-8 alkylene chain, wherein one or more carbons are optionally replaced by —O— and the chain is optionally substituted by one or more halogen atoms, X is 5 or 6 membered heteroaryl group containing at least one nitrogen atom and optionally including 1 or 2 further heteroatoms selected from O, S and N; Q is selected from: a) a saturated or unsaturated, branched or unbranched C 1-10 alkyl chain, wherein at least one carbon (for example 1, 2 or 3 carbons) is replaced by a heteroatom selected from O, N, S(O) p , wherein said chain is optionally, substituted by one or more groups selected from oxo, halogen, an aryl group, a heteroaryl group or an heterocyclyl group, each aryl, heteroaryl or heterocyclyl group bearing 0 to 3 substituents selected from halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, amino, C 1-4 mono or di-alkyl amino, with the proviso that the atom linked directly to the carbonyl in —NR 3 C(O)— is not an oxygen or a sulfur atom; and b) a C 0-8 alkylC 5-6 heterocyclyl said heterocyclyl group comprising at least one heteroatom selected from O, N and S, and optionally substituted by one or two or three groups independently selected from halogen C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, amino, C 1-4 mono and di-alkyl amino; and p is 0, 1 or 2; or a pharmaceutically acceptable salt or solvate thereof, including all stereoisomers and tautomers thereof.