Patent ID: 7041670

Claim:
A compound having the chemical formula: wherein R 2 and R 3 are independently selected from the group consisting of hydrogen, (1C-4C)alkyl, halo, —CF 3 , —NH 2 , —CN and N 3 ; wherein R 4 is selected from the group consisting of: wherein A 1 is carbon or nitrogen, and carbon atoms in the ring are independently substituted with an entity selected from the group consisting of hydrogen, (1C-4C) alkyl, (3C-6C)cycloalkyl, (1C-4C)alkylO—, —CF 3 , —OH, —CN, halo, (1C-4C)alkylSO—, (1C-4C)alkylSO 2 —, NH 2 SO 2 —, (1C-4C)alkylNHSO 2 —, ((1C-4C)alkyl) 2 NSO 2 —, —NH 2 , (1C-4C)alkylNH—, ((1C-4C)alkyl) 2 N—, (1C-4C)alkylSO 2 NH—, (1C-4C)alkylC(O)—, (3C-6C)cycloalkylC(O)—, (1C-4C)alkylOC(O)—, (1C-4C)alkylC(O)NH—, —C(O)NH 2 , (1C-4C)alkylNHC(O)— and ((1C-4C)alkyl) 2 NC(O)—, wherein any of the alkyl groups within the substituents may be unsubstituted or substituted with a group selected from halo and hydroxy; wherein A 2 , A 3 , A 4 , an A 5 are independently selected from the group consisting of carbon, nitrogen, oxygen and sulfur, provided that at least one of A 1 -A 5 is not carbon, that the total number of nitrogen, oxygen and sulfur atoms in the ring does not exceed 4 and that the ring is aromatic; and wherein if A 1 is carbon and the ring does not contain oxygen or sulfur, one of the nitrogen atoms may optionally be substituted with an entity selected from the group consisting of (1C-4C)alkyl, (1C-4C)alkylSO 2 — and —NH 2 ; and wherein A 6 , A 7 , A 8 , A 9 and A 10 are independently selected from the group consisting of carbon, nitrogen and provided that only one of A 6 -A 10 at a time can be and that one, two, or three of the A 6 -A 10 atoms are nitrogen; and wherein the carbon atoms in the ring are independently substituted with an entity selected from the group consisting of hydrogen, (1C-4C)alkyl, (3C-6C)cycloalkyl, (1C-4C)alkylO—, —CF 3 , —OH, —CN, halo, (1C-4C)alkylSO—, (1C-4C)alkylSO 2 —, NH 2 SO 2 —, (1C-4C)alkylNHSO 2 —, ((1C-4C)alkyl) 2 NSO 2 —, —NH 2 , (1C-4C)alkylNH—, ((1C-4C)alkyl) 2 N—, (1C-4C)alkylSO 2 NH—, (1C-4C)alkylC(O)—, (3C-6C)cycloalkylC(O)—, (1C-4C)alkylOC(O)—, (1C-4C)alkylC(O)NH—, —C(O)NH 2 , (1C-4C)alkylNHC(O)—, ((1C-4C)alkyl) 2 NC(O)— and —OCH 2 O—, wherein the oxygen atoms with the —OCH 2 O— substituent being bonded to adjacent ring carbon atoms, and wherein any of the alkyl groups within any of the substituents may be unsubstituted or substituted with a group selected from halo and hydroxy; and wherein R 8 is hydrogen in all compounds, except when R 2 and R 3 are both F, in which case R 8 is hydrogen or F; and, the compound is either a racemate having the relative stereochemistry shown or is substantially enantiomerically pure and has the absolute stereochemistry shown.