Patent ID: 8093266

Claim:
A compound of formula I wherein: X is —C(O)NR 1 R 2 or —NHC(O)R 1 ; Y is —N(R 8 )C(O)NR 9 —, —N(R 8 )C(O)— or —C(O)N(R 8 )—; W is C or N; n is 1 or 2; R 1 is selected from: R 2 is selected from H, C 1-6 alkyl and methoxyC 2-4 alkyl; R 3 , R 4 , and R 5 are independently selected from: H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, Cl, F, Br, —CN, —CH 2 CN, —CF 3 , —OCHF 2 , —OCF 3 , —C(O)NH 2 , —C(O)C 1-3 alkyl, —NHC(O)NH 2 , and —SC 1-3 alkyl; or R 3 and R 4 together with the benzene ring they are bonded to form a quinoline ring; R 6 and R 7 are independently selected from H and C 1-6 alkyl, or R 6 and R 7 , together with the nitrogen to which they are bound, may form a morpholine ring; R 8 and R 9 are independently selected from H, C 1-3 alkyl and benzyl; R 10 is selected from H, C 1-6 alkyl, —CH 2 pyridyl, —CH 2 CO 2 C 1-4 alkyl, —CH 2 C(O)NH 2 , —CH 2 CH 2 OC 1-4 alkyl, —CH 2 CH 2 CN, —CH 2 CHF 2 ,—(CH 2 ) 1-2 CF 3 , —CH 2 CH 2 F, —CH(CO 2 Me)CH 2 CO 2 C 1-4 alkyl, and benzyl, wherein said benzyl group is optionally substituted with one to two groups selected from R 3 and R 4 ; R 11 and R 12 are independently selected from H and C 1-6 alkyl; or R 11 and R 12 , together with the nitrogen they are attached to, form a morpholine ring, a 4-methyl-1-piperazinyl ring, a thiomorpholine ring, optionally with a dioxo substituent at the sulfur atom, or a 1,3-dihydroisoindole ring; R 13 is selected from —(CH 2 ) r N(R 6 )(R 7 ), —OCH 2 CH 2 (4-morpholinyl), —CH 2 CH 2 (1-pyrrolidinyl), —CH 2 (1-pyrazolyl) and —CH 2 -(5-methyl-4H-[1,2,4]triazol-3-yl); m is 3-6; r is 0-2; and p is 0-1; with the proviso that if Y =—C(O)NR 8 — and n=1, then X is not —C(O)NR 1 R 2 and if Y is —N(R 8 )C(O)NR 9 —, then n is not 2; or a tautomer or a salt thereof.