Patent ID: 7605159

Claim:
A compound of formula (I): R 1 is independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R 2 is independently aryl, heteroaryl or a group C 1-6 alkylR 9 , CO(C 1-6 alkyl)R 9 or SO 2 (C 1-6 alkyl)R 9 ; Het is a heteroaryl ring chosen from pyridine, pyrimidine, pyrazine, pyridazine or triazine and optionally substituted by halogen, amino, hydroxy, cyano, nitro, carboxy, CONR 12 R 13 , SO 2 NR 12 R 13 , SO 2 R 12 , trifluoromethyl, NHSO 2 R 12 , NHCOR 12 , C 1-6 alkyl, C 1-6 alkoxy, SR 12 or NR 10 R 11 ; R 3 is independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R 4 is independently hydrogen, C 1-8 alkyl, C 3-8 cycloalkyl, arylC 1-5 alkyl or heteroarylC 1-5 alkyl, the latter three groups being optionally substituted by one or more halogen, amino, hydroxy, C 1-6 alkyl, C 1-6 l alkoxy, SR 12 or NR 10 R 11 ; R 5 is independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R 6 is independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R 7 is independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R 8 is independently hydrogen, aryl, heteroaryl or C 1-6 alkyl optionally substituted with one or more aryl, heteroaryl, halogen, amino, hydroxy, carboxy, CONR 12 R 13 , SO 2 NR 12 R 13 , SO 2 R 12 , NHSO 2 R 12 , NHCOR 12 , C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, SR 12 or NR 10 R 11 ; R 9 is aryl or heteroaryl; R 10 and R 11 are independently hydrogen, C 1-6 alkyl or together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated ring optionally containing a further O, S or NR 1 group; and R 12 and R 13 are independently hydrogen or C 1-6 alkyl; or a pharmaceutically acceptable salt thereof.