Patent ID: 7860656

Claim:
A method for diagnosis of hepatic steatosis in a patient or from a serum or plasma sample of a patient, comprising the steps of: a) determining the value of 9 biochemical markers by measuring the values of their concentration in the serum or plasma of said patient, wherein said markers are: ApoA1 (apolipoprotein A1), alpha.2-macroglobulin, ALT (alanine aminotransferase), GGT (gammaglutamyl transpeptidase), Triglycerides, total bilirubin, haptoglobin, glucose, and cholesterol; b) determining the value of one clinical marker chosen in the group constituted of the body mass index (Weight/Height 2 ), the waist measurement, and the (waist measurement/hip measurement) ratio; c) combining the concentration values of the 9 biochemical markers of step a), one clinical marker of step b), and the age and gender of the patient through a logistic function in order to obtain an end value, wherein said logistic function is obtained through the following method: i) classification of a cohort of patients in different groups according to the extent of their disease; ii) identification of factors which differ significantly between these groups by unidimensional analysis; iii) logistic regression analysis to assess the independent discriminative value of markers for the diagnosis of hepatic steatosis; iv) construction of the logistic function by combination of the identified independent factors; and d) analyzing said end value of said logistic function in order to determine the presence of hepatic steatosis in said patient.