Patent ID: 7572641

Claim:
A method of identifying a solid meloxicam pharmaceutical formulation having comparable in vivo pharmacokinetic parameters to a reference meloxicam pharmaceutical formulation by in vitro analysis comprising: providing at least one pharmaceutical formulation comprising meloxicam particles; dissolving in vitro the pharmaceutical formulation using an U.S.P. Dissolution Apparatus 2 (paddle apparatus) filled with a dissolution medium of 1000 ml of 0.01M KH 2 PO 4 aqueous solution at a pH of about 7.5 at about 37° C. and a rotation speed of about 75 rpm; dissolving in vitro the reference meloxicam pharmaceutical formulation using an U.S.P. Dissolution Apparatus 2 (paddle apparatus) filled with a dissolution medium of 1000 ml of 0.01M KH 2 PO 4 aqueous solution at a pH of about 7.5 at about 37° C. and a rotation speed of about 75 rpm; determining the amount by weight of meloxicam dissolved from the reference meloxicam pharmaceutical formulation and the amount by weight of meloxicam dissolved from the meloxicam pharmaceutical formulation after about 15 minutes from starting the dissolution of each formulation; comparing the amount by weight of meloxicam dissolved from the pharmaceutical formulation to the amount of meloxicam dissolved from the reference pharmaceutical formulation; and identifying the pharmaceutical formulation having the amount of dissolved meloxicam comparable to the amount of dissolved meloxicam of the reference pharmaceutical formulation.