Patent ID: 7968082

Claim:
A method of processing an enoxaparin preparation comprising: performing 2D-NMR to determine an amount of an epoxide, a reducing end 2-O sulfated uronic acid and a 1,6 anhydro mannosamine present in an enoxaparin preparation, and if the amount of the epoxide, the reducing end 2-O sulfated uronic acid and the 1,6 anhydro mannosamine is present in an amount within a preselected range, processing said preparation, wherein said processing includes one or more of selecting, accepting, processing into drug product, shipping, formulating, labeling, packaging or selling said preparation, and if the amount of the epoxide, the reducing end 2-O sulfated uronic acid or the 1,6 anhydro mannosamine is not present in an amount within the preselected range, discarding or withholding the preparation, wherein the preselected range of the epoxide corresponds to between 0.6 and 1.0 percent composition, wherein the preselected range of the reducing end 2-O sulfated uronic acid corresponds to between 0.8 and 1.4 percent composition, wherein the preselected range of the mannosamine corresponds to between 2.1 and 2.9 percent composition, and wherein the percent composition is calculated using the specific cross peak volumes for which all uronic acid residues have similar 1 J CH couplings as do all glucosamine residues.