Patent ID: 8765130

Claim:
An isolated monovalent antagonistic anti-DR3 antibody, the antibody comprising a heavy chain variable region comprising a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3 and a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3, the heavy chain CDR1 comprising an amino acid sequence corresponding to Kabat residues 31-35 of SEQ ID NO:10; the heavy chain CDR2 comprising an amino acid sequence corresponding to Kabat residues 50-58 of SEQ ID NO:10; the heavy chain CDR3 comprising an amino acid sequence corresponding to Kabat residues 95-102 of SEQ ID NO:10; the light chain CDR1 comprising an amino acid sequence corresponding to Kabat residues 24-34 of SEQ ID NO:11; the light chain CDR2 comprising an amino acid sequence corresponding to Kabat residues 50-56 of SEQ ID NO:11; and the light chain CDR3 comprising an amino acid sequence corresponding to Kabat residues 89-97 of SEQ ID NO:11.