Patent ID: 8580267

Claim:
A method of treating glioblastoma in an individual, comprising administering a chemotherapeutic agent and an immunocytokine to the individual, wherein the chemotherapeutic agent is temozolomide and wherein the immunocytokine comprises interieukin-2 (IL2) conjugated to an antibody molecule that binds domain A1 of tenasin-C large isoform, wherein the antibody molecule comprises an antibody-antigen binding site comprising a VH domain and a VL domain, the VH domain comprising: a VH CDR1 of SEQ ID NO: 18 or a VH CDR1 of SEQ ID NO:5; a VH CDR2 of SEQ ID NO: 6; and a VH CDR3 of SEQ ID NO: 7; and the VL domain comprising: a VL CDR1 of SEQ ID NO:8; a VL CDR2 of SEQ ID NO:9; and a VL CDR3 of SEQ ID NO:10.