Patent ID: 6916817

Claim:
A compound of the formula I wherein ring B represents a pyridyl ring; each R3 is independently selected from hydrogen, halogen, NO 2 , COOR wherein R is hydrogen or C 1-6 alkyl, CN, CF 3 , C 1-6 alkyl, —S—Cl 6 alkyl, —SO—C 1-6 alkyl, C 1-6 alkoxy and up to C 10 aryloxy, n is 1, 2, or 3; P is —(CH 2 )n- wherein n=0, 1, 2, or P is an alkene or alkyne chain of up to six carbon atoms; Ring A represents a piperazinyl ring optionally mono- or di- substituted by a C 1-6 alkyl or C 1-6 alkoxy, wherein said C 1-6 alkyl or C 1-6 alkoxy may independently be further substituted with a halogen, C 1-6 alkyl or an oxo group; X 1 and X 2 are N; Y is selected from —SO 2 — and —CO—; Z is —CONHOH, Y is —CO— and Q is selected from —C(R6)(R7)-, —C(R6)(R7)-CH 2 —, —N(R6)-, and —N(R6)-CH 2 — wherein R6 is as defined above, and solely in relation to Q as here defined, R6 may also represent up to C 10 aryl and up to C 9 heteroaryl, and R7 is H, C 1-6 alkyl, or together with R6 forms a carbocyclic or heterocyclic spiro 5, 6 or 7 membered ring, the latter containing at least one heteroatom selected from N, O, and S; Z is —CONHOH, Y is —SO 2 — and Q is selected from —C(R6)(R7)-, and —C(R6)(R7)-CH 2 —; or Z is —N(OH)CHO and Q is selected from —CH(R6)-, —CH(R6)-CH 2 —, and —N(R6)-CH 2 —; R1 is H, or C 1-6 alkyl; Z is selected from —COOH, —CONHOH, —N(OH)CHO and N(OH)COR wherein R is C 1-6 alkyl, up to C 10 aryl and up to C 9 aralkyl And R2 is a ring having 5-7 ring atoms and comprising one or two ring heteroatoms independently selected from oxygen, nitrogen and sulphur, the ring being optionally substituted by (i) Y—R9 wherein R9 is C 1-6 alkyl, up to C 10 aryl, up to C 12 aralkyl or up to C 12 heteroaryl(hetero)alkyl, or (ii) Y-T-R9 wherein Y and R9 are as previously defined and T is oxygen or N—R8 wherein R8 is hydrogen or C 1-6 alkyl the heteroatom(s) being independently selected from oxygen, nitrogen and sulphur, R9 and R8 independently being optionally substituted by one or two groups selected from halogen, NO 2 , CN, CF 3 , C 1-6 alkyl, —S—C 1-6 alkyl, —SO—C 1-6 alkyl, —SO 2 —C 1-6 alkyl and C 1-6 alkoxy; or a pharmaceutically-acceptable salt or in vivo hydrolysable precursor thereof.