Patent ID: 7608626

Claim:
A compound of formula (1): or a pharmaceutically acceptable salt thereof; wherein R is H, C 1 -C 6 alkyl, C 6 -C 10 aryl, 5 to 10 membered heteroaryl having 1 to 3 heteroatoms each independently selected from nitrogen, oxygen and sulfur, or —C(O)R′, wherein R′ is C 1 -C 6 alkyl, C 6 -C 10 aryl, or 5 to 10 membered heteroaryl having 1 to 3 heteroatoms each independently selected from nitrogen, oxygen and sulfur; R 1 is H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, or C 1 -C 6 fluoroalkyl; R 2 is C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 fluoroalkyl, C 6 -C 10 aryl, or 5 to 10 membered heteroaryl having 1 to 3 heteroatoms each independently selected from nitrogen, oxygen and sulfur; R 3 is C 3 -C 6 alkyl, C 1 -C 6 alkyl-C 3 -C 8 cycloalkyl, or C 1 -C 6 fluoroalkyl; or alternatively R 2 and R 3 can be taken together with the carbon atoms to which they are attached to form a ring of 5-8 carbon atoms; R 4 , R 5 , R 6 , and R 7 are each independently H, halogen, cyano, hydroxyl, carboxyl, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 alkoxy, C 1 -C 6 fluoroalkoxy, C 6 -C 10 aryl, C 6 -C 10 aryloxy, 5 to 10 membered heteroaryl having 1 to 3 heteroatoms each independently selected from nitrogen, oxygen and sulfur, C 2 -C 8 alkenyl, C 2 -C 6 alkanoyl, C 2 -C 6 alkanoyloxy, C 2 -C 6 alkoxycarbonyl, carboxamido, C 2 -C 6 alkanamido, C 1 -C 6 alkanesulfonamido, amino, C 1 -C 6 monoalkylamino, dialkylamino of 1 to 6 carbon atoms per alkyl moiety, C 3 -C 8 cycloalkyl, or a 3 to 8 membered heterocycloalkyl having 1 to 3 heteroatoms each independently selected from nitrogen, oxygen and sulfur; R 8 is H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, or C 6 -C 10 aryl; wherein any cycloalkyl or heterocycloalkyl group is saturated or partially saturated, and any aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group may optionally be substituted with 1 to 5 substituents independently selected from halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 alkoxy, and C 1 -C 6 fluoroalkoxy.