Patent ID: 7345094

Claim:
A method of treating a subject with melanoma, said method comprising administering to the subject an effective amount of paclitaxel or a paclitaxel analog and an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein: Y is a covalent bond, phenylene group or a substituted or unsubstituted hydrocarbyl group, or, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group; R 1 and R 2 are independently an aryl group or a substituted aryl group; R 3 and R 4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group; R 5 -R 6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group; and Z is ═O or ═S.