Patent ID: 7622253

Claim:
A kit for determining a survival probability of a patient diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL), the kit comprising: reagents for measuring expression of a plurality of predictive genes in a sample from the patient diagnosed with DLBCL, the plurality of predictive genes including LMO2, BCL-6, FN1, CCND2, SCYA3, and BCL-2; and electronic media comprising software including a first algorithm for correlating a normalized expression data set from the plurality of predictive genes from the patient to expression data sets from the plurality of predictive genes obtained from DLBCL patients with known survival data, the plurality of predictive genes including LMO2, BCL-6, FN1, CCND2, SCYA3, and BCL-2; where a survival probability output is determined using the weighted predictor Z, according to the formula: Z =( A×LMO 2)+( B×BCL 6)+( C×FN 1)+( D×CCND 2)+( E×SCYA 3)+( F×BCL 2); wherein, A is −0.03, B is −0.2, C is −0.2, D is 0.03, E is 0.2, and F is 0.6; and LMO2, BCL6, FN1, CCND2, SCYA3, and BCL2 are log base 2 of normalized expression values for genes LMO2, BCL-6, FN1, CCND2, SCYA3, and BCL-2, respectively.