Patent ID: 7863302

Claim:
A compound of formula p is 0 or 1; R 1 and R 2 are independently selected from the group consisting of hydrogen, â€”C 1 -C 6 alkyl, â€”C 1 -C 6 haloalkyl, â€”C 1 -C 6 alkoxy-, â€”C 1 -C 6 haloalkoxy-, halo, â€”SR 11 , and â€”Sâ€”C 1 -C 3 haloalkyl; each R 3 is independently selected from the group consisting of â€”C 1 -C 6 alkyl, â€”C 1 -C 6 haloalkyl, â€”C 1 -C 6 alkoxy-, â€”C 1 -C 6 haloalkoxy-, and halo; R 4 is selected from the group consisting of hydrogen, â€”C 1 -C 6 alkyl, â€”C 1 -C 6 haloalkyl, â€”C 3 -C 8 cycloalkyl, â€”C 4 -C 8 alkylcycloalkyl, â€”C 1 -C 6 alkoxy-, and â€”C 1 -C 6 haloalkoxy-; R 5 and R 5a are independently selected from the group consisting of hydrogen, and â€”C 1 -C 3 alkyl; R 6 is selected from the group consisting of hydrogen, â€”C 1 -C 6 alkyl, â€”C 1 -C 6 haloalkyl, and halo; Ar 1 is selected from the group consisting of indolyl, pyridinyl, thienyl, benzothienyl, indazolyl, benzothiazolyl, benzoisoxazolyl, benzofuranyl, and thiazolyl, each optionally substituted with one or two groups independently selected from the group consisting of hydroxy, â€”C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, â€”C 1 -C 4 alkylSO 2 C 1 -C 2 alkyl, â€”C 1 -C 4 alkylSC 1 -C 2 alkyl, â€”C 1 -C 4 alkylNR 10 R 11 , phenyl, â€”C 1 -C 4 alkyl-Oâ€”C 1 -C 4 alkyl, and â€”NHC(O)R 10 ; R 7 is selected from the group consisting of â€”CH 2 COOR 10 , â€”COOR 10 , â€”CONR 11 R 11 , â€”C(O)NHSO 2 C 1 -C 4 alkyl, â€”C(O)NHSO 2 R 12 , oxadiazolethione, and oxadiazolone; each R 10 is independently selected from the group consisting of hydrogen, â€”C 1 -C 4 alkyl, and phenyl; each R 11 is independently hydrogen, or â€”C 1 -C 6 alkyl; R 12 is â€”C 1 -C 6 alkyl or phenyl optionally substituted with â€”C 1 -C 3 alkyl, or a pharmaceutically acceptable salt thereof.