Patent ID: 7045517

Claim:
A method for treating an interleukin-12 overproduction-related disorder, wherein the disorder is rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus, comprising administering to a subject in need thereof the compound of formula (I): wherein R 1 is aryl, or heteroaryl; each of R 2, R 4, and R 5, independently, is R c , halogen, nitro, nitroso, cyano, azide, isothionitro, SR c , or OR c ; R 3 is R c , alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, OR c OC(O)R c , SO 2 R c , S(O 2 )R c , S(O 2 )NR c R d , SR c , NR c R d , NR c COR d , NR c C(O)OR d , NR c C(O)NR c R d , NR c SO 2 R d , COR c , C(O)OR c or C(O)NR c R d ; n is 0, 1, 2, 3, 4, 5, 6, or 7; X is O, S, S(O), S(O 2 ), or NR c ; Y is a covalent bond, CH 2 , C(O), C═N—R c , C═N—OR c , C═N—SR c , O, S, S(O), S(O 2 ), or NR c . Z is N or CH; and W is O, S, S(O), S(O 2 ), NR c , or NC(O)R c ; in which each of R a and R b , independently, is H, alkyl, aryl, heteroaryl; and each of R c and R d , independently, is H, alkyl, or alkylcarbonyl; or a pharmaceutically acceptable salt thereof.