Patent ID: 8524774

Claim:
A method for the treatment of psoriasis by use of a topical step-wise polytherapy, to a person in need thereof, comprising steps 1 and 2: Step 1) Topically applying daily to a symptomatic portion of the skin a first composition comprising: a) 4 to 40% of 4 or more cetylated fatty esters selected from the group consisting of cetyl arginine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-y-linolenate, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl isolaurate, cetyl laurate, cetyl linolenate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetyl stearate, cetyl stearidonate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms; b) 5 to 30% of one or more polar solvents selected from the group consisting of propylene glycol, glycerol, ethylene glycol, 1,2,6-hexane triol, 1,2,4-butane triol, propylene glycol ether of methyl glucose or sorbitol, PEG 40 hydrogenated castor oil, dimethicone copolyol and polyethylene glycol; and c) a pharmaceutically acceptable vehicle; and Step 2) Topically applying a second composition, 2-3 times a week to the same portion of skin as the first composition, wherein the second composition comprises: a) 4 to 40% of 4 or more cetylated fatty esters selected from the group consisting of cetyl arginine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-y-linolenate, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl isolaurate, cetyl laurate, cetyl linolenate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetyl stearate, cetyl stearidonate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms; b) 1 to 20% of a keratolytic agent; and c) a pharmaceutically acceptable vehicle.