Patent ID: 7070945

Claim:
A kit for determining the presence of monomeric brain associated human glutamine synthetase in a body fluid of a patient diagnosed with mild cognitive impairment (MCI) comprising: at least one antibody that binds monomeric brain associated human glutamine synthetase having a weight of about 44 kDa, wherein said antibody is selected from the group consisting of the antibody encoded by the clone deposited with the ATCC as Accession Number PTA-3339 and the antibody encoded by the clone deposited with the ATCC as Accession Number PTA-3340, said antibody immobilized on a solid support; wherein an elevated presence of said monomeric brain associated human glutamine synthetase in said body fluid of said patient diagnosed with mild cognitive impairment (MCI) is associated with an elevated risk of developing Alzheimer's dementia.