Patent ID: 8466191

Claim:
A compound of Formula (I) or Formula (II), a pharmaceutically acceptable salt, or hydrate thereof, wherein A and B independently represent CH 2 , CO, SO, or SO 2 ; D represents S, NH, or NC 1-6 alkyl; R 1 represents H, or one or two same or different occurrences of F, Cl, Br, C 1-4 alkyl, OH, OC 1-4 alkyl, NO 2 , NHC(O)C 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), or N(C 1-4 alkyl) 2 ; R 2 at each occurrence represents F, CF 3 , H, or C 1-4 alkyl; R 3 at each occurrence represents OH, CH(OH)C 1-4 alkyl, OC 1-4 alkyl, NHC(O)C 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , C(O)OC 1-4 alkyl, C(O)NH 2 , C(O)NH(C 1-4 alkyl), C(O)N(C 1-4 alkyl) 2 , C(O)NHOH, C(O)NH(OC 1-4 alkyl), C(O)C 1-4 alkyl, S(O)C 1-4 alkyl, SO 2 C 1-4 alkyl, SO 2 NHC 1-4 alkyl, NHSO 2 C 1-4 alkyl, NHC(O)C 1-4 alkyl, CN, CH═NOH, CH═N(OC 1-4 alkyl), C(C 1-4 alkyl)=NOH, C(C 1-4 alkyl)=N(OC 1-4 alkyl), CH═NCN, CH═NC(O)C 1-4 alkyl, CH═C(CN) 2 , CH═CHNO 2 , C(═NH)NH(C 1-4 alkyl), C(C 1-4 alkyl)=NCN, C(C 1-4 alkyl)=NC(O)C 1-4 alkyl, C(C 1-4 alkyl)=C(CN) 2 , or C(C 1-4 alkyl)=CHNO 2 ; R 4 represents C 1-8 alkylhydrocarbyl, or (CH 2 ) n Ar—R 5 ; Ar represents a 4- to 8-membered hydrocarbon ring or an aromatic ring containing from 0 to 4 heteroatoms; R 5 represents H, 1 to 4 same or different F, CF 3 , CN, Cl, C 1-4 alkyl, OH, OC 1-4 alkyl, NHC(O)C 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , C(O)OC 1-4 alkyl, OOCC 1-4 alkyl, C(O)NH 2 , C(O)NH(C 1-4 alkyl), C(O)N(C 1-4 alkyl) 2 , C(O)C 1-4 alkyl, S(O)C 1-4 alkyl, SO 2 C 1-4 alkyl, O 2 CC 1-4 alkyl, E, or W—(CH 2 ) l E; E represents a 4- to 8-membered hydrocarbon ring or an aromatic ring containing 0 to 4 heteroatoms; W represents O, S, NH, or CH 2 ; l represents 0, 1, 2, 3, or 4; m represents 0, 1, 2, 3, 4, 5, or 6; and n represents 0, 1, 2, 3 or 4.