Patent ID: 7652014

Claim:
A compound of formula (I), the N-oxide forms, the addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0 or 1; s is 0 or 1; X is —N═ or —CR 4 ═, wherein R 4 is hydrogen or taken together with R 1 may form a bivalent radical of formula —CH═CH—CH═CH—; Y is —N< or —CH<; Q is —NH—, —O—, —C(O)—, —CH 2 —CH 2 — or —CHR 5 —, wherein R 5 is hydrogen, hydroxy, C 1-6 alkyl, arylC 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxyC 1-6 alkylamino or haloindazolyl; R 1 is C 1-6 alkyl or thienyl; R 2 is hydrogen; R 3 is hydrogen, C 1-6 alkyl or a radical selected from —NR 6 R 7 (a-1), —O—H (a-2), —O—R 8 (a-3), —S—R 9 (a-4), or —C≡N (a-5), wherein R 6 is —CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkylcarbonylaminoC 1-6 alkyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, thienylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindozolylpiperidinylC 1-6 alkyl, or arylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl; and R 7 is hydrogen or C 1-6 alkyl; R 8 is C 1-6 alkyl, C 1-6 alkylcarbonyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; and R 9 is di(C 1-6 alkyl)aminoC 1-6 alkyl; or R 3 is a group of formula —(CH 2 ) t —Z— (b-1), wherein t is 0, 1 or 2; Z is a heterocyclic ring system selected from wherein each R 10 independently is hydrogen, C 1-6 alkyl, aminocarbonyl, hydroxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, di(phenylC 2-6 alkenyl), piperidinylC 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, morpholino, C 1-6 alkylimidazolyl, or pyridinylC 1-6 alkylamino; each R 11 independently is hydrogen, hydroxy, piperidinyl or aryl; aryl is phenyl or phenyl substituted with halo, C 1-6 alkyl or C 1-6 alkyloxy.