Patent ID: 7135484

Claim:
A compound of formula (IV) wherein represents a double bond; Y is a covalent bond; Z is CH 2 ; R 1 is hydrogen: R 2 is hydrogen; R 3 and R 5 are absent; and R 4 is heterocycle, wherein the heterocycle is selected from the group consisting of furyl, imidazolyl, isothiazolyl, isoxazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrrolyl, tetrazinyl, tetrazolyl, thiadiazolyl, thiazolyl, thienyl, triazinyl, triazolyl, benzimidazolyl, benzothiazolyl, benzothienyl, benzoxazolyl, benzofuranyl, cinnolinyl, furo[2,3-c]pyridine, furo[3,2-c]pyridine, furo[3,2-b]pyridinyl, furo[2,3-b]pyridinyl, imidazo[1,2-a]pyridinyl, indazolyl, indolyl, indolizinyl, naphthyridinyl, isobenzofuranyl, isobenzothienyl, isoindolyl, isoquinolinyl, phthalazinyl, quinolinyl, quinolizinyl, quinoxalinyl, quinazolinyl, thieno[2,3-c]pyridine, thieno[3,2-c]pyridine, thieno[3,2-b]pyridinyl, and thieno[2,3-b]pyridinyl wherein the heterocycle is substituted with 0, 1, 2, or 3 substituents independently selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylthio, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, phenyl, triphenylmethyl (trityl), —C(NH)NR 10 R 11 , —NR 10 R 11 , (NR 10 R 11 )alkyl, (NR 10 R 11 )carbonyl, (NR 10 R 11 )carbonylalkyl, (NR 10 R 11 )sulfonyl, —NR 12 S(O) 2 R 13 , —C(NR 12 )NR 13 R 14 , —CH 2 C(NR 12 )NR 13 R 14 , —C(NOR 12 )R 13 , —C(NCN)R 12 , —C(NNR 12 R 13 )R 14 , —S(O) 2 OR 12 , and —S(O) 2 R 12 , wherein R 10 and R 11 are independently selected from hydrogen, alkyl or alkylcarbonyl, and R 12 , R 13 , and R 14 are independently selected from hydrogen, alkyl, aryl, or arylalkyl.