Patent ID: 8535715

Claim:
A bilayer tablet comprising: (1) a first layer wherein the first layer is a metformin extended release formulation comprising about 50-87% metformin hydrochloride (HCl) in an amount of 1000 mg, about 1-10% sodium carboxymethyl cellulose, about 10-40% hydroxypropyl methylcellulose, about 0.1-75% magnesium stearate, and about 0-2% silicon dioxide or about 0-1.5% colloidal silicon dioxide, in which weight percents are calculated relative to the total weight of the first layer; (2) a second layer wherein the second layer is a sodium-dependent glucose transporter (SGLT2) inhibitor formulation having a total weight in the range of about 300 mg to about 400 mg and comprising about 0.1-10% of an SGLT2 inhibitor selected from dapagliflozin, dapagliflozin (S) propylene glycol hydrate and dapagliflozin (R) propylene glycol hydrate, about 5-30% lactose anhydrous, about 40-90% microcrystalline cellulose, about 0-25% pregelatinized starch, about 0-20% hydroxypropyl cellulose, about 0-25% mannitol, about 1-10% crospovidone, about 0.1-5% silicon dioxide, and about 0.1-5% magnesium stearate, in which weight percents are calculated relative to the total weight of the second layer; and (3) optionally a film coating that covers the first layer and the second layer, wherein the weight ratio between the first layer and the second layer is about 4.4:1.