Patent ID: 8586542

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or hydrate form thereof; and including any stereoisomeric forms thereof; wherein each of ring A and ring A′ independently represents a saturated 3-8 membered monocyclic azacyclic ring or a saturated 8-12 membered fused polycyclic azacyclic ring, each of which may contain 0-2 additional heteroatoms selected from N, O, S as ring members; and wherein ring A is substituted with a group represented as —W—X, and ring A′ is substituted with a group represented as W′—X′, and each of ring A and ring A′ may be optionally substituted with from 1-4 additional substituents suitable for its structure; each J and J′ is independently H, CN, C1-C4 alkyl or C1-C4 alkyloxycarbonyl; each W and W′ independently represents C═O, C═S, or an optionally substituted C 2 -C 6 alkylene or C 2 -C 6 heteroalkylene; or W and/or W′ can be a bond where X and/or X′ comprises an optionally substituted 5-membered or 6-membered aryl or heteroaryl ring; each X and X′ independently represents an optionally substituted C5-C20 ring system comprising at least one aromatic ring and up to four heteroatoms selected from N, O and S, and can represent either a single 5-15 membered cyclic group or two 5-10 membered cyclic groups that are both attached to the same atom of W or W′, provided that each X and X′ comprises at least one aryl or heteroaryl ring; each Q and Q′ independently represents —CH 2 —, —CH(OR)—, —CH(R)—, —(CH 2 ) r A-, —CH(R)A-, or —CR═CR— or —C≡C—, wherein r is 1-4, each A is independently O, NR, or S, and wherein each R is independently H, C 1 -C 8 alkyl or C 1 -C 8 heteroalkyl; or one or both of Q and Q′ can be a bond where L comprises a ring; each R 1 and R 1′ is independently H or optionally substituted C1-C4 alkyl; each Z and Z′ is independently an optionally substituted C1-C6 aminoalkyl; and L represents a linker that is a C2-C20 hydrocarbyl group, optionally containing from 1-6 heteroatoms selected from N, O and S, which linker is 2 to 10 atoms in length when counted along the shortest path between Q and Q′, and which may be optionally substituted; with the proviso that L does not comprise a disulfide bond.