Patent ID: 7250443

Claim:
A compound having the structure: wherein: X is nitrogen, oxygen, or optionally substituted carbon; W is absent or is selected from the group consisting of —O—, —S—, —S(O)—, —SO 2 —, —NH—, —NH—CO—, —NR′CO—, —NHSO 2 —, —NR′SO 2 —, —CO—, —CO 2 —, —CH 2 —, —CF 2 —, —CHF—, —CONH—, —CONR′—, and —NR′—, where R′ is alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo; A 1 is an optionally substituted six-membered heterocyclic group having N as the only ring heteroatom; R 0 and R 0 ′ are independently selected from the group consisting of hydrogen and methyl; R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, and optionally substituted loweralkyl, cycloloweralkyl, cyclicaminoalkyl, alkylaminoalkyl, loweralkoxy, amino, alkylamino, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, and aryl; R 5 and R 8 are independently selected from the group consisting of hydrogen, halo, and optionally substituted loweralkyl, cycloalkyl, alkoxy, amino, aminoalkoxy, carbonyloxy, aminocarbonyloxy, alkylcarbonylamino, arylcarbonylamino, aralkylcarbonylamino, cycloimido, amidino, cycloamidino, guanidinyl, aryl, biaryl, and arylsulfonamido; R 6 is selected from the group consisting of hydrogen and optionally substituted aryl; R 7 is selected from the group consisting of hydrogen, hydroxy, halo, carboxyl, nitro, amino, amido, amidino, imido, cyano, sulfonyl, methanesulfonyl, and substituted or unsubstituted alkyl, alkoxy, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkylcarbonyloxy, arylcarbonyloxy, aralkylcarbonyloxy, alkylaminocarbonyloxy, arylamino-carbonyloxy, formyl, loweralkylcarbonyl, loweralkoxycarbonyl, aminocarbonyl, aminoaryl, alkylsulfonyl, sulfonamido, aminoalkoxy, alkylamino, alkylcarbonylamino, alkylaminocarbonylamino, arylaminocarbonylamino, aralkylcarbonylamino, arylcarbonylamino, cycloamido, cyclothioamido, cycloamidino, cycloalkyl, cycloimido, guanidinyl, aryl, arylsulfonyl and arylsulfonamido; the tautomers thereof; or a pharmaceutically acceptable salt thereof.