Patent ID: 8633320

Claim:
A method for preparing a compound of formula (I), comprising reacting a 2,4-dichloro-7-alkoxy quinoline (III) with a brominating agent and then reacting the resulting 8-bromo-2,4-dichloro-7-alkoxy quinoline (IV) with a Suzuki coupling reagent selected from an R-boronic acid, R-boronate ester, R-potassium trifluoroborate or R-organoborane, by a Suzuki coupling reaction to replace the 2-chloro group with an R group according to the following reaction: where R is: an aryl, heteroaryl, alkyl, alkenyl or alkynyl group, wherein the aryl and heteroaryl may each be optionally substituted with one or more groups independently selected from halogen, alkyl, halogenated alkyl, alkoxy, amido or amino optionally substituted by one or more alkyl and/or amino protecting groups; and Alk is a lower alkyl group.