Patent ID: RE43372

Claim:
A compound having the structure: wherein a) R 1 is selected from the group consisting of CO 2 H, C(O)NHOH, C 2 R 3 ,CH 2 OH, S(O) 2 R 3 , C(O)NHR 3 . C(O)NHS(O) 2 R 4 , and tetrazole, wherein R 3 is alkyl, heteroalkyl, carbocyclic aliphatic ring, heterocyclic alphatic ring, monocyclic aromatic ring, or monocyclic heteroaromatic ring; and R 4 is alkyl, heteroalkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, monocyclic aromatic ring, or monocyclic heteroaromatic ring; (b) R 2 is H or lower alkyl; (c) X is a covalent bond; (d) Z is an aromatic ring or a heteroaromatic ring provided that when Z is a heteroaromatic ring and X is a covalent bond, Z is attached to C 15 via a Carbon member atom; and (e) any optical isomer, diastereomer enantiomer of the above structure or a pharmaceutically-acceptable salt, or bio-hydrolyzable amide, ester, or imide thereof.