Patent ID: 7834011

Claim:
A compound of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein R 1 is hydroxy or a radical of formula (a-1) wherein R 2 is hydroxy or amino; R 3 is hydrogen, thienyl, furanyl or phenyl and each thienyl, furanyl or phenyl can optionally be substituted with one or two halo, amino, nitro, cyano, hydroxy, phenyl, C 1-6 alkyl, (diC 1-6 alkyl)amino, C 1-6 alkyloxy, phenylC 1-6 alkyloxy, hydroxyC 1-6 alkyl, C 1-6 alkyloxycarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonyl, polyhaloC 1-6 alkyloxy, polyhaloC 1-6 alkyl, C 1-6 alkylsulfonyl, hydroxycarbonylC 1-6 alkyl, C 1-6 alkylcarbonylamino, aminosulfonyl, aminosulfonylC 1-6 alkyl, isoxazolyl, aminocarbonyl, phenylC 2-6 alkenyl, phenylC 3-6 alkynyl or pyridinylC 3-6 alkynyl; R 4 , R 5 and R 6 are each independently hydrogen, amino, nitro, furanyl, halo, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, thienyl, phenyl, C 1-6 alkylcarbonylamino, aminocarbonylC 1-6 alkyl or —C≡C—CH 2 —R 7 ; wherein R 7 is hydrogen, C 1-6 alkyl, hydroxy, amino or C 1-6 alkyloxy; X is N or CH; Y is O, N, NH, CH or CH 2 and when Y is N or CH then the substituent is attached to the Y atom of the ring structure; T is O or NR 8 wherein R 8 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, hydroxyC 1-6 alkyl, cyanoC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, hydroxyaminocarbonylC 1-6 alkyl, C 1-6 alkylsulfonyl, C 1-6 alkylcarbonyl, C 1-6 alkylaminocarbonyl or mono- or di(C 1-6 alkyl)aminosulfonyl; n is 0 or 1 and when n is 0 than a direct bond is intended; m is 1 or 2; p is 0 or 1 provided that when p is 0 then n is 0, —(CH 2 ) n -(T) p - is a direct bond and Y is N; A is a radical selected from: wherein R 9 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl or C 3-7 cycloalkylC 1-6 alkyl; and R 10 is hydrogen, hydroxy, amino, halo, cyano, C 1-6 alkyl, polyhaloC 1-6 alkyl, C 1-6 alkyloxycarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkyloxy, or mono- or di(C 1-6 alkyl)amino.