Patent ID: 8389549

Claim:
A compound of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein: Ar 1 is Ar 2 is X is O or S; Q 1 is O, S, or NH; R 1 is hydrogen, halo, (C 1 -C 4 )alkyl, nitro, cyano, hydroxy, methoxy, amino, trihalomethyl, dihalomethyl, halomethyl, OC(halo) 3 , OCH(halo) 2 , or OCH 2 (halo); each R 2 is an alkyl group substituted with two hydroxy groups; each of Y 1 , Y 2 , and Y 3 is C or NR′, provided that at least one of Y 1 , Y 2 , and Y 3 is CR′, wherein R′ is H or (C 1 -C 6 )alkyl; each R 3 is independently (a) hydrogen, —CH 2 OR 7 , or (C 1 -C 6 )alkyl; (b) two R 3 groups together form a (C 2 -C 6 )bridge, which is unsubstituted or substituted with 1, 2 or 3 independently selected R 8 groups, and which bridge optionally contains —HC═CH— within the (C 2 -C 6 )bridge; or (c) two R 3 groups together form a —CH 2 —N(R a )—CH 2 — bridge, a or a R a is —H, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, —CH 2 —C(O)—R c , —(CH 2 )—C(O)—OR c , —(CH 2 )—C(O)—N(R c ) 2 , —(CH 2 ) 2 —O—R c , —(CH 2 ) 2 —S(O) 2 —N(R c ) 2 , or —(CH 2 ) 2 —N(R c )S(O) 2 —R c ; each R b is independently: (a) —H, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, -(3- to 7-membered)heterocycle, —N(R c ) 2 , —N(R c )—(C 3 -C 8 )cycloalkyl, or —N(R c )-(3- to 7-membered)heterocycle; or (b) phenyl, (5- or 6-membered)heteroaryl, —N(R c )-phenyl, or —N(R c )-(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R 7 groups; each R c is independently —H or (C 1 -C 4 )alkyl; each R 8 is independently (a) (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 5 -C 8 )cycloalkenyl, or phenyl, each of which is optionally substituted with 1 or 2 hydroxy groups, or (b) H, CH 2 C(halo) 3 , C(halo) 3 , CH(halo) 2 , CH 2 (halo), OC(halo) 3 , OCH(halo) 2 , OCH 2 (halo), SC(halo) 3 , SCH(halo) 2 , SCH 2 (halo), O—CN, CN, OH, halo, N 3 , NO 2 , CH═NR 7 , N(R 7 ) 2 , NR 7 OH, OR 7 , C(O)R 7 , C(O)OR 7 , OC(O)R 7 , OC(O)OR 7 , SR 7 , S(O)R 7 , S(O) 2 R 7 or SO 2 CH 2 (halo)O(C 1 -C 6 )alkyl; R 7 is H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 5 -C 8 )cycloalkenyl, phenyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-N(R 20 ) 2 , or CON(R 20 ) 2 ; each of R 9 and R 10 is independently hydrogen or (C 1 -C 6 )alkyl; or together with the carbon atom to which they are attached form a C 3 -C 6 carbocycle; R 20 is H, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, hydroxy(C 1 -C 4 )alkyl, or (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl; each n is 0, 1, or 2; each of m, o, and s is independently 0, 1, 2, 3, or 4; p is 1, 2, or 3; and each of q and r is independently 0, 1, 2, 3, 4, or 5.