Patent ID: 8030305

Claim:
A compound of Formula I: and N-oxides, prodrugs, pharmaceutically acceptable salts, and stereochemical isomers thereof, wherein: R 1 is diazole or benzodiazole optionally substituted with one, two or three R a substituents; wherein R a is —NH 2 , halogen, alkoxy, alkylthio, alkylsulfonyl, phenylsulfonyl, heteroarylsulfonyl, heterocyclylsulfonyl, —SO 2 NH 2 , alkyl, aminoalkyl, alkylamino, phenyl, heteroaryl, cyano, alkenyl, alkynyl, cycloalkyl, heterocyclyl, —CO 2 -alkyl, —C(O)—R b , —C (1-4) alkyl-morpholinyl, —C (1-4) alkyl-piperidinyl, —C (1-4) alkyl-piperazinyl, —C (1-4) alkyl-N′-methyl piperazinyl, —C (1-4) alkyl-R b , —C(O)NH—C (1-4) alkyl-R b , or —C(O)NR c R d ; wherein R b is heterocyclyl, alkylsulfonyl, —SO 2 NH 2 , alkylsulfonamide, —OH, —Oalkyl, —NH 2 , —NHalkyl, or —N(alkyl) 2 ; R c and R d are independently selected from the group consisting of H, phenyl, heteroaryl, or C 1-6 alkyl, wherein said C 1-6 alkyl may optionally be substituted with one substituent selected from: —N(CH 3 ) 2 , morpholinyl, piperidinyl, piperazinyl, N-methyl piperazinyl, alkylsulfonyl, —SO 2 NH 2 , alkylsulfonamide, hydroxyl, and alkoxy; or R c and R d together may form a 5 to 7 membered heterocyclic ring, optionally containing a second heteromoiety selected from O, NH, N(alkyl), SO, SO 2 , or S; wherein said R c -R d heterocyclic ring is optionally substituted with alkyl, —SO 2 alkyl, or —C(O)alkyl; A is a ring selected from the group consisting of phenyl, mono or bicyclic heteroaryl, 3-(4-Methoxy-benzyl)-3H-quinazolin-4-on-6-yl, quinazolin-4-on-6-yl, and benzo-fused heterocyclyl; wherein said phenyl, heteroaryl, or benzo-fused heterocyclyl are optionally substituted with one to three substituents independently selected from the group consisting of: —OH, alkyl, phenyl, heteroaryl, alkoxy, —CN, halogen, nitro, —NH 2 , —N(CH 3 ) 2 , —NHC(O)NHC 1-6 alkyl, and —NHC(O)C 1-6 alkyl; and R 7 and R 8 are H, halogen or C 1-6 alkyl.