Patent ID: 7541466

Claim:
A compound represented by structural formula Ib: wherein: X1 and X2 are independently —C(O)— or —S(O)—; X3, X4, X5, and X6 are —CH—; Ring B is optionally substituted at any substitutable carbon; m is 0, 1 or 2; each R4 is independently halogen, —OH, —SH, —R a , —OR a , —SR a , —NH 2 , —NHR a , —NR a 2 , —C(O)NR a 2 , —CF 3 , —CN, or —NO 2 ; and i) R1 is —H; R2 is —X7-R6, wherein X7 is a covalent bond, a C5-C12 linear or branched aliphatic group containing 1, 2, or 3 double bonds, or a C1-C12 alkyl chain optionally interrupted by —O— or —S—; R6 is —SH, diphenylmethylene, or a 5 or 6 membered aryl, heteroaryl, heterocyclic or monocyclic C4-C6 cycloalkyl group; each cyclic group represented by R6 is optionally substituted with one or more groups selected from C4-C6 cycloalkyl, halogen, —CF 3 , —R d , —OR d , —SR d , —COR d , —OH, —SH, phenyl, phenoxyl, benzyl, benzoyl, N-morpholinyl, —NR d 2 , —NR d COR e , N-aniline, —NO 2 , and —CN; or, R1 and R2, taken together with the nitrogen to which they are bonded, are an optionally substituted 6-membered heterocyclic group; and R3 is a six-membered aryl or heteroaryl group that is substituted or is fused to another ring; or ii) R1 and R2 are independently —H or an optionally substituted aliphatic, aryl, heteroaryl, heterocyclic, or monocyclic cycloalkyl group, provided that R1 and R2 are not both —H; or, R1 and R2, taken together with the nitrogen to which they are bonded, are an optionally substituted heterocyclic group; and R3 is an optionally substituted 2-naphthyl, 6-(1,4 benzodioxan)yl, 6-indolyl, or 2-(9-fluorenon)yl group, or a phenyl or pyridyl group substituted with one or more groups selected from halogen, —CF 3 , —NO 2 , —CN, —R c , —OR c , and —XR f ; wherein optional substituents on the aliphatic group are, independently, —OH, halogen (—Br, —Cl, —I and —F), —R, —OR, —CH 2 R, —CH 2 CH 2 R, —OCH 2 R, —CH 2 OR, —CH 2 CH 2 OR, —CH 2 OC(O)R, —O—COR, —COR, —SR, —SCH 2 R, —CH 2 SR, —SOR, —SO 2 R, —CN, —NO 2 , —COOH, —SO 3 H, —COOR, —CHO, —CONH 2 , —CONHR, —CON(R) 2 , —NHCOR, —NRCOR, —NHCONH 2 , —NHCONRH, —NHCON(R) 2 , —NRCONH 2 , —NRCONRH, —NRCON(R) 2 , —C(═NH)—NH 2 , —C(═NH)—NHR, —C(═NH)—N(R) 2 , —C(═NR)—NH 2 , —C(═NR)—NHR, —C(═NR)—N(R) 2 , —SO 2 NH 2 , —SO 2 NHR, —SO 2 NR 2 , —SH, and —SO k R (k is 0, 1 or 2); each R being, independently, an unsubstituted alkyl, cycloalkyl, benzyl, aryl, or heteroaryl group; wherein X is—O—, —S—, —C(O)—, —S(O)—, —CH 2 —, —CH 2 CH 2 —, —OCH 2 —, —OCH 2 CH 2 —, —SCH 2 —, or —SCH 2 CH 2 —; each R a and R c is independently a C1-C5 branched or linear alkyl group; each R d and R e is independently a C1-C7 branched or linear alkyl group; and R f is an optionally substituted phenyl, pyridyl, N-pyridyl, N-morpholinyl, furanyl, thienyl, isoxazolyl, imidazolyl, pyrazolyl, pyrrolyl, pyrrolidyl, piperidyl, piperazyl, benzofuranyl, tetrazolyl, thiazolyl, tetrazolyl, benzothiazolyl, benzimidazolyl cyclobutyl, cyclopentyl, or cyclohexyl group.