Patent ID: 8173690

Claim:
A compound having the following structure: or a pharmaceutically acceptable salt, ester, or tautomer thereof, wherein: W is O or S; R 1 is H, F, Cl, Br, I, —CH 2 F, —CF 2 H, —CF 3 , —CN, —OH, —NO 2 , —NH 2 , —NH(C 1-4 alkyl), —N(C 1-4 alkyl)(C 1-4 alkyl), —SO 2 CH 3 , —SO 2 NH 2 , —SO 2 NHCH 3 , —CO 2 —C 1-4 alkyl, C 1-4 alkyl, C 1-4 alkenyl, C 1-4 alkoxy, C 1-4 S-alkyl, C 3-6 cycloalkyl, optionally substituted C 1-6 heterocycloalkyl, optionally substituted phenyl, or optionally substituted 5 or 6 membered heteroaryl; R d is F, Cl, Br, I, CF 3 , aryl, heteroaryl, CN, NO 2 , NH 2 , NHR′, OH, OR′, SH, SR′, C(O)R′, CO 2 H, COOR′, CONH 2 , CONHR′, CONR′R″, SO 3 H, SO 3 R′, S(O) 2 R′, S(O) 2 NH 2 , S(O) 2 NHR′, or S(O) 2 NR′R″; R d1 is zero to four substituents independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, halo, CN, NH 2 , NHR′, NR′R″, OH, OR′, SH, SR′, C(O)R′, CO 2 H, COOR′, CONH 2 , CONHR′, CONR′R″, SO 3 H, S(O) 2 R′, S(O) 2 NH 2 , S(O) 2 NHR′, or S(O) 2 NR′R″; each R′ is independently methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl or phenyl; each R″ is independently methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl or phenyl; or R′ and R″ are together with the atom to which they are attached form an optionally substituted, saturated or unsaturated 4-, 5- or 6-membered ring; R x and R x′ are each independently H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted heteroalkenyl, optionally substituted heteroalkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, halo, CN, NH 2 , NHR′, NR′R″, OH, OR′, SH, SR′, C(O)R′, CO 2 H, COOR′, CONH 2 , CONHR′, CONR′R″, SO 3 H, S(O) 2 R′, S(O) 2 NH 2 , S(O) 2 NHR′, or S(O) 2 NR′R″; or R x and R x′ together with the carbon atom to which they are attached, form an optionally substituted non-aromatic 3-7 membered ring, optionally comprising 1 or 2 heteroatoms selected from O, N and S; B 3 is OB 1 , NB 2 2 , or an amino acid residue or an alkyl ester thereof; B 1 is H, optionally substituted C 1-6 alkyl or a pharmaceutically acceptable cation; and each B 2 is independently H or optionally substituted alkyl.