Patent ID: 7160874

Claim:
A phenylalanine compound of the following general formula (1) or a pharmaceutically acceptable salt thereof: wherein X represents a group of the formula —NR 1 C(═O)—, wherein R 1 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s) or a lower alkyl group substituted with a heteroaryl group(s), Y represents a group of the formula —C(═O)—, Z represents a group of the formula —C(═O)—, A represents a group of formula (2): wherein R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different from one another, and each represents a hydrogen atom, a halogen atom, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, or a heteroaryl group, B represents a hydroxyl group, C represents a hydrogen atom, D and E may be the same or different and each represent a lower alkyl group, a lower alkenyl group, or D and E may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms, K represents NR 7 R 8 or NHNR 7 R 8 , wherein R 7 and R 8 may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), or a lower alkyl group substituted with a heteroaryl group(s), or R 7 and R 8 may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms; and the substituents of the ring include hydrogen atom, a halogen atom, hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkanoyl group, an aroyl group, a halogeno-lower alkanoyl group, a lower alkyloxy group, nitro group, cyano group, a substituted or unsubstituted amino group, carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkylthio group, a lower alkylsulfonyl group or a substituted or unsubstituted sulfamoyl group, and J and J′ each represents a hydrogen atom.