Patent ID: 8623872

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein the dotted lines represent optional bonds: X is >N— —N Y—is —N—C(O)—or —N═CR 4 —, wherein R 4 is hydroxy; L is a direct bond or a bivalent radical selected from —C(O)—, —C(O)—NH—, —NH—, —C(O)—C 1-6 alkanediyl-, —C(O)—O—C 1-6 alkanediyl- or —C 1-6 alkanediyl-; R 1 is hydrogen, halo, C 1-6 alkyloxy or C 1-6 alkyl; R 2 is hydrogen, hydroxy, C 1-6 alkyloxy or aminocarbonyl; when X is substituted with R 2 than R 2 taken together with -L-Z can form a bivalent radical of formula —C(O)—NH—CH 2 —NR 10 — (a-1) wherein R 10 is phenyl; R 3 is hydrogen, or C 1-6 alkyloxy; Z is wherein each R 5 , R 6 , R 7 and R 8 is independently selected from hydrogen, halo, amino, C 1-6 alkyl or C 1-6 alkyloxy; or R 7 and R 8 taken together may form a bivalent radical of formula —CH 2 —CR 9 2 —O— (c-1), —(CH 2 ) 3 —O— (c-2), —O—(CH 2 ) 2 —O— (c-3) or —CH═CH—CH═CH— (c-4) wherein each R 9 is independently selected from hydrogen or C 1-6 alkyl.