Patent ID: 8263565

Claim:
A method of promoting fibroblast proliferation and collagen biosynthesis of the skin in a subject in need thereof, comprising topically applying to the subject's skin a skin-care composition containing a nanoemulsion that comprises metabolites of ginseng saponin as an effective component in an amount of 0.001%-50% by weight based on the total weight of the nanoemulsion composition, wherein said metabolites of ginseng saponin are extracted and purified from red ginseng, and wherein said metabolites of ginseng saponin are an admixture of 30-50 wt % 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol represented by the following formula 1 wherein, R 1 is O-Glc, R is OH and R 3 is H; 5-25 wt % 20-O-β-D-glucopyranosyl-20(S)-protopanaxatriol represented by the following formula 2 wherein, R 1 is O-Glc, R 2 is OH and R 3 is OH; and 5-25 wt % 20-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol represented by the following formula 3 wherein R 1 is O-Glc 6 - 1 Arap, R 2 is OH and R 3 is H.