Patent ID: 7582611

Claim:
A compound having a structure represented by formula (I) and the pharmaceutically acceptable salts, solvates, and hydrates thereof, wherein (A) R A is (i) OR 1 ; (ii) O(CH 2 ) m C(═O)R 2 ; (iii) OC(═O)R 4 ; (iv) OS(O 2 )N(R 3 R 3A ); (v) O(CH 2 ) n NHR 5 ; (vi) N(H)S(O 2 )R 6 ; (vii) OCH 2 CH 2 OCH 2 CH 2 C(═O)R 2 ; or (viii) OCH 2 CH 2 OCH 2 CH 2 NHR 5 ; (B) R B is selected from the group consisting of C 2 -C 4 alkyl, C 3 -C 4 alkenyl, or C 3 -C 4 alkynyl, 3- or 4-membered cycloaliphatic, and 3- or 4-membered heterocycloaliphatic, each member of the group being optionally substituted with one or more substituents selected from the group consisting of OH, CN, and halogen; (C) R C is H or OH; (D) R D is H or Me; (E) R E is H or OH; and (F) R F is H or Me; wherein R 1 is C 1 -C 4 alkyl, which C 1 -C 4 alkyl is optionally substituted with OH, CN, O(C 1 -C 3 alkyl), halogen, aryl, cycloaliphatic, heteroaryl, or heterocycloaliphatic, said aryl, cycloaliphatic, heteroaryl and heterocycloaliphatic moieties being optionally substituted with C 1 - C 4 alkyl; R 2 is OR 3 , N(R 3 R 3A ), C 1 -C 4 alkyl, (CH 2 ) n OH, or C 2 -C 4 haloalkyl; R 3 is H, C 1 -C 4 alkyl, or (CH 2 ) n OH; R 3A is H, C 1 -C 4 alkyl, (CH 2 ) n OH, (CH 2 ) n O(C 1 -C 2 alkyl), C 2 -C 4 haloalkyl, C 1 -C 4 alkyl(aryl), C 1 -C 4 alkyl(heteroaryl), O(C 1 -C 4 alkyl), heteroaryl, or wherein X is N or CH; Y is O, S, NH, N(C 1 -C 3 alkyl), CH 2 , or a bond; each p is (i) independently 1 or 2 when X is CH 2 ; (ii) 2 when X is N and Y is other than CH 2 or a bond; and (iii) independently 1 or 2 when X is N and Y is CH 2 or a bond; and q is (i) 0, 1, 2, or 3 when X is CH and (ii) 2 or 3 when X is N; R 4 is N(R 3 R 3A ) or C 1 -C 4 alkyl; R 5 is S(O 2 )(C 1 -C 4 alkyl), C(═O)(C 1 -C 4 alkyl), C(═O)aryl, C(═O)(heteroaryl ), C(═O)H, or C(═W)NH(C 1 -C 4 alkyl), where W is O or S; R 6 is C 1 -C 4 alkyl, cyclobutyl, cyclopropyl, CF 3 , or N(R 3 R 3A ); m is 1, 2, 3, 4, 5, or 6; and n is, independently for each occurrence thereof, 2, 3 or 4.