Patent ID: 7011956

Claim:
In a coagulation assay for determining the propensity of patient risk for thrombotic disease wherein a phospholipid comprising phosphatidylethanolamine and phosphatidylserine is employed as a reagent and activated protein C is utilized in the assay, the improvement comprising conducting said assay with an oxidized phospholipid reagent to obtain a first result and a non-oxidized phospholipid reagent otherwise identical in composition to said oxidized phospholipid reagent to obtain a second result, and comparing said first and second result, and if said first result is prolonged in comparison to said second result, concluding that said patient is likely normal but if said first result is essentially the same as said second result, concluding that said patient likely has antibodies which block the function of oxidized phospholipids to a greater extent than unoxidized phospholipids and that said patient risk for thrombotic disease is higher than that observed for normal patients.