Patent ID: 7189749

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof wherein A is a C 1 –C 4 alkylene group optionally substituted with C 1 –C 2 alkyl or mono- or disubstituted with halogen; X is oxygen, sulfur or NR 6 , wherein each R 6 is hydrogen, cyano or an alkyl group of 1–6 carbon atoms which may be substituted with one or more halogens; R 1 , R 2 , R 3 and R 4 are each independently hydrogen, halogen, or nitro, or an alkyl group of 1–6 carbon atoms optionally substituted with one or more halogens; OR 7 , SR 7 , S(O)R 7 , S(O) 2 R 7 , C(O)N(R 7 ) 2 , or N(R 7 ) 2 , wherein each R 7 is independently hydrogen, an alkyl group of 1–6 carbon atoms which may be substituted with one or more halogens or benzyl, where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, amino, and mono- or di(C 1 –C 6 )alkylamino; phenyl which is optionally substituted with up to three groups independently selected from halogen, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, amino, and mono- or di(C 1 –C 6 )alkylamino; phenoxy where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, amino, and mono- or di(C 1 –C 6 )alkylamino; or R 5 is hydroxy, C 1 –C 6 alkoxy, or —O − M + where M + is a cation forming a pharmaceutically acceptable salt; and Ar represents benzothiazolyl which is optionally substituted with up to five groups independently selected from halogen, nitro, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, C 1 –C 6 alkylthio, trifluoromethyl, trifluoromethoxy, C 1 –C 6 alkylsulfinyl, and C 1 –C 6 alkylsulfonyl.