Patent ID: 8598158

Claim:
A compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein E is phenyl, or is a monocyclic or bicyclic heteroaryl ring containing five to 10 ring atoms, wherein said heteroaryl ring contains from one to four heteroatoms selected from the group consisting of N, O, and S; R 1 and R 2 are independently present or absent, and if present, are independently (C 1 -C 6 ) alkyl, halo, (C 1 -C 6 ) alkoxy, —CN, (C 1 -C 6 ) haloalkyl, azido, —C(═O)—(C 1 -C 6 )alkyl, —S(O)—(C 1 -C 6 )alkyl, or —S(O) 2 —(C 1 -C 6 )alkyl, amino, (C 1 -C 6 ) alkylamino, di(C 1 -C 6 )alkylamino, carbamyl, —NH—C(═O)—(C 1 -C 6 ) alkyl, or hydroxyl; M is —O—, —S(O)—, —S(O) 2 —, (C 1 -C 4 ) alkylene, (C 1 -C 4 ) alkenylene, (C 1 -C 4 )alkynylene, fluoro(C 1 -C 4 )alkylene, hydroxy(C 1 -C 4 )alkylene, or alkoxy(C 1 -C 4 )alkylene; or M is absent, such that E is bonded directly to ring A; X 1 is O or S; R 9 is H, (C 1 -C 6 ) alkyl, or halo; each occurrence of R 10 is independently H, (C 1 -C 3 ) alkyl, fluoro, (C 1 -C 3 ) fluoroalkyl, or (C 1 -C 3 ) alkoxy; R 3 is H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, or (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, or R 3 is a group of the formula -J-K, wherein J is (C 1 -C 3 ) alkylene, —C(═O)—, or —C(═S)—; K is (C 3 -C 10 ) cycloalkyl, (C 6 -C 10 ) aryl, 5- to 6-membered heteroaryl, or 5- to 6-membered heterocyclyl, wherein said cycloalkyl, aryl, heteroaryl, or heterocyclyl of K is unsubstituted or substituted with one to four moieties, wherein said moieties are the same or different, and wherein said moieties are selected from the group consisting of (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, halo, amino, (C 1 -C 6 ) alkylamino, di(C 1 -C 6 )alkylamino, —CN, —OCF 3 , and R 25 ; R 25 is (C 6 -C 10 ) aryl or 5- to 6-membered heteroaryl, wherein said aryl or heteroaryl of R 25 is unsubstituted or substituted with one to four moieties, wherein said moieties are selected from the group consisting of (C 1 -C 6 ) alkyl, hydroxyl, (C 1 -C 6 ) alkoxy, halo, amino, (C 1 -C 6 ) alkylamino, di(C 1 -C 6 )alkylamino, —CF 3 , —OCF 3 , or —CN; R 4 is absent, halo, —CN, (C 1 -C 6 ) alkyl, or (C 1 -C 6 ) fluoroalkyl; wherein D is a heterocyclic or heteroaryl ring selected from the group consisting of: wherein R 6 and R 7 are independently absent or present, and if present, are independently (C 1 -C 3 ) alkyl, (C 1 -C 3 ) fluoroalkyl, —CH 2 —O—(C 1 -C 3 )alkyl, —CH 2 CH 2 —O—(C 1 -C 3 )alkyl, or —CH 2 CH 2 CH 2 —O—(C 1 -C 3 )alkyl, and wherein R 6 and R 7 are substituted on a carbon atom; R 18 is H, —CN, hydroxy, (C 1 -C 6 ) alkyl, or (C 1 -C 6 ) alkoxy; and R 19 is H or (C 1 -C 3 ) alkyl.