Patent ID: 8660649

Claim:
A multi-site cranial stimulation method, comprising applying individual stimuli to different regions of a brain by means of the application of specific stimulus signals to corresponding stimulation elements arranged adjacent to said regions of said brain, wherein said cranial stimulation is a transcranial alternating current electrical stimulation wherein said stimulation elements used are noninvasive, wherein the method comprises constructing at least one simplified model of the brain or of a sector thereof, considering the brain or said sector thereof as a non-linear coupled oscillating system, and comprises determining said stimulus signals so that they are suitable for exciting at least one natural vibration mode of said non-linear coupled oscillating system, and wherein the method further comprises adapting or self-calibrating in real time said stimulus signals to the changes observed in the brain activity, by means of: monitoring the brain activity of said brain at least prior to and/or during the application of said stimulus signals, using one or more analysis techniques applied to said monitored signals to distinguish between the electric signals induced by the stimuli and natural bioelectric signals or response signals to said stimuli, considering said electric signals induced by the stimuli as unwanted signals, and performing a proper filtering of the monitored signals in order to clean said unwanted signals from those which are really indicative of brain activity; and controlling said stimulation by means of varying said stimulus signals depending on the monitored brain activity, from the filtered monitored signals free of said unwanted signals.