Patent ID: 7247304

Claim:
A method of treating psoriasis caused by the proinflammatory effects of human IL-15, comprising administering to a subject an isolated human monoclonal antibody, or antigen binding portion thereof, which binds to human IL-15 and inhibits IL-15 signalling through the IL-15 receptor in an amount effective to treat the disorder and wherein the antibody comprises (a) a heavy chain variable region comprising (i) a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:5; (ii) a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:6; and (iii) a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:7; and (b) a light chain variable region comprising (i) a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:8; (ii) a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:9; and (iii) a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:10.