Patent ID: 8183289

Claim:
A compound having the formula Ia wherein R 1 is Ar 1 -L 1 -W-L 2 -; L 2 is —(CR c R d ) m —; W is —CONR 3a —or —NR 3b —(CO)—; R 3a and R 3b are each H or methyl; L 1 is —(CR a R b ) n —, —(CH═CH)—, or —O(CR a R b )—, provided that when W is —NR 3 CO—then L 1 is not —(CH═CH)—; n and m are independently 0, 1 or 2; each R a , R b , R c and R d is independently H, F, methyl or cyclopropyl, or R a and R b or R c and R d together with the carbon to which they are attached form a cyclopropyl ring; Ar 1 is phenyl or naphthyl, each of which is unsubstituted or substituted with one or more substituents selected independently from F, Cl, CN, CF 3 , CHF 2 , CH 2 F, SF 5 , methyl, ethyl and cyclopropyl, provided that when Ar 1 is naphthyl then n is 0; R 2 is H, C 1 -C 6 alkyl, an amino acid residue, or CHR e (CH 2 ) q R f ; q is 1 to 6; R e is H, methyl or ethyl; R f is NR g R h in which R g and R h each independently represents a hydrogen atom or a C 1 -C 4 alkyl group, or R g and R h together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring optionally containing a second ring heteroatom selected from N and O,wherein said heterocyclic ring is optionally substituted with one or more groups independently selected from C 1 -C 6 alkyl; A is CN, CH 2 NH 2 , CH 2 NR 4a C(═O)R 5 , CH 2 NR 4b SO 2 R 6 , Cl, OMe, (1-4C)alkyl, or cyclopropyl; R 4a and R 4b are each H or methyl; R 5 is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, hetAr 1 , or Ar 2 ; R 6 is C 1 -C 6 alkyl, NH(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2 , Ar 3 , or hetAr 2 ; hetAr 1 is a 6 membered heteroaryl which is unsubstituted or substituted with one or more groups independently selected from a halogen atom and a group of formula —NR 5a R 5b in which each of R 5a and R 5b independently represents a hydrogen atom or a (1-4C) alkyl group, or together with the nitrogen atom to which they are attached form a pyrrolidinyl, piperidinyl or morpholino group; hetAr 2 is a 5-6 membered heteroaryl which is unsubstituted or substituted with one or more groups independently selected from C 1 -C 4 alkyl; Ar 2 is phenyl which is unsubstituted or substituted with one or more groups independently selected from a halogen atom, CN, SF 5 , cyclopropyl, a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group and a fluoroC 1 -C 4 alkyl group; Ar 3 is as defined for Ar 2 ; and R 7 and R 8 are independently H or methyl.