Patent ID: 8877769

Claim:
A chemical entity selected from compounds of Formula (I): wherein Ar 1 is isoxazolo[5,4-c]pyridin-3-yl, isoxazolo[4,5-c]pyridin-3-yl, isoxazolo[4,5-b]pyridin-3-yl, isoxazolo[5,4-b]pyridin-3-yl, imidazo[1,2-a]pyridin-8-yl, imidazo[1,2-a]pyridin-7-yl, imidazo[1,2-a]pyridin-6-yl, imidazo[1,2-a]pyridin-5-yl, imidazo[1,2-b]pyridazin-3-yl, imidazo[1,2-a]pyridin-3-yl, imidazo[1,2-a]pyridin-2-yl, imidazo[1,2-a]pyrimidin-7-yl, imidazo[1,2-a]pyrimidin-5-yl, imidazo[1,2-c]pyrimidin-7-yl, benzooxazol-6-yl, 1,1-dioxo-1H-1λ 6 -benzo [d]isothiazol-3-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, 1H-pyrrolo[2,3-b]pyridin-4-yl, 1H-pyrrolo[3,2-b]pyridin-6-yl, 1H-pyrazolo[3,4-b]pyridin-5-yl, benzooxazol-5-yl, 1H-indazol-7-yl, 4-chloro-isoxazol-3-yl, or 2H-indazol-4-yl; where each Ar 1 is optionally substituted with one or two groups individually selected from —C 1-3 alkyl, halo, —CF 3 , —OC 1-3 alkyl, or —OCF 3 ; Z is >CH; Ar 2 is (i) phenyl unsubstituted or substituted with one or two R a moieties; where each R a moiety is independently —C 1-8 alkyl, —OC 1-8 alkyl, halo, —CF 3 , —O(CH 2 ) 0-1 CF 3 , —S(O) 0-2 C 1-4 alkyl, —S(O) 0-2 CF 3 , —(CH 2 ) 0-1 CO 2 C 1-4 alkyl, —CO 2 H, —N(R b )R c , —SO 2 NR b R c , —C(O)NR b R c , —C≡C—R d , —NR b SO 2 R g , —NO 2 , —(CH 2 ) 1-6 —O—C 1-6 alkyl, —(CH 2 ) 1-6 —S(O) 0-2 —C 1-6 alkyl, or —(CH 2 ) 0-1 CN; or two adjacent R a moieties taken together form —O(CH 2 ) 1-2 O— or —OCF 2 O—; where R b and R c are each independently H or —C 1-4 alkyl or taken together with the atoms of attachment form a 4-8 membered ring; R d is H, —C 1-8 alkyl, or —CH 2 NR e R f ; where R e and R f are each independently H or —C 1-8 alkyl or taken together with the atoms of attachment form a 4-8 membered ring; R g is —H or —C 1-4 alkyl; (ii) phenyl substituted at the 3- or 4-position with -L-Ar 3 , unsubstituted or substituted with one or two R a moieties, wherein L is a linker selected from the group consisting of —(CH 2 ) 1-6 —, —, (CH 2 ) 0-3 —O—(CH 2 ) 0-3 —, —CH═CH——NH—, >NC 1-4 alkyl, —S(O) 0-2 —, —C≡C—, —C(O)—, or a covalent bond; Ar 3 is (a) phenyl unsubstituted or substituted with one or two R a moieties; (b) naphthyl unsubstituted or substituted with one or two R a moieties; or (c) a monocyclic or bicyclic heteroaryl group unsubstituted or substituted with one or two R a moieties; or (iii) a 9- or 10-membered fused bicyclic heteroaryl group unsubstituted or substituted with one or two R a moieties; and pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of compounds of Formula (I).