Patent ID: 8287839

Claim:
A method of bimodal cancer treatment in a subject comprising the administration to the subject of a composition comprising a compound of the formula wherein: R 1 , R 2 , R 3 , and R 4 are independently â€”NO 2 , â€”NH 2 , halogen, or a substituent represented by the following formula wherein Y are independently on the ortho, meta or para position on the phenyl rings, and are independently hydrogen, hydrocarbyl, non-aromatic carbocyclic, non-aromatic heterocyclic, aryl, alkylaryl, or arylalkyl; or a hydrocarbyl, non-aromatic carbocyclic, non-aromatic heterocyclic, aryl, alkylaryl, or a arylalkyl group substituted with 1 to 4 hydrophilic groups selected from hydroxy, alkoxy, â€”C(O)OR 5 , â€”SOR 6 , â€”SO 2 R 6 , nitro, amido, ureido, carbamato, â€”SR 7 , â€”NR 8 R 9 , or poly-alkyleneoxide; or a substituent represented by formula (3) â€”Xâ€”(CR 10 R 11 ) r â€”Zâ€ƒâ€ƒ(3); provided that at least one of R 1 , R 2 , R 3 , and R 4 is the substituent represented by formula (2) wherein Y represents formula (3); wherein: X is oxygen or sulfur; R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 11 are independently selected from hydrogen and C 1 to C 4 hydrocarbyl; Z is a carborane cluster comprising at least two carbon atoms and at least three boron atoms, or at least one carbon atom and at least five boron atoms, within a cage structure; r is 0 or an integer from 1 to 20; a represents an integer from 1 to 4; and provided also that at least one of R 1 , R 2 , R 3 , and R 4 is the substituent represented by â€”NO 2 , â€”NH 2 , or halogen; and M is either two hydrogen ions, a single monovalent metal ion, two monovalent metal ions, a divalent metal ion, a trivalent metal ion, a tetravalent metal ion, a pentavalent metal ion, a hexavalent metal ion, wherein the compound derived from the single monovalent metal ion is charge-balanced by a counter cation, and the compound derived from the trivalent, tetravalent, pentavalent, hexavalent metal ion is charge-balanced by an appropriate number of counter anions, dianions, or trianions; and the irradiation of said subject, wherein said irradiation comprises X-ray radiation therapy (XRT).