Patent ID: 7064143

Claim:
A compound of Formula I: wherein: R 1 is selected from hydrogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl or C 2 –C 4 alkynyl; W is selected from C(O)O or C(O)NR 6 ; R 2 is selected from hydrogen, C 1 –C 4 alkyl, Ar, or (CH 2 ) p CH[(CH 2 ) q R 7 ](CH 2 ) t R 8 ; R 3 is hydrogen; R 5 is selected from hydrogen or C 1 –C 4 alkyl; X is selected from oxygen, or NH; R 4 is selected from C 1 –C 4 alkyl; R 6 is selected from hydrogen, C 1 –C 4 alkyl or aryl; R 7 and R 8 are independently selected from hydrogen, halogen, OR 10 , NR 10 R 11 , C(O)OR 10 , OC(O)R 10 , C(O)NR 10 R 11 , NR 10 C(O)R 11 , SO 2 NR 10 R 11 , or NR 10 SO 2 R 11 ; Ar is selected from phenyl or naphthyl; Ar is optionally substituted with one or more substituents independently selected from: hydrogen, halogen, C 1 –C 4 alkyl, C 2 –C 4 alkenyl, C 2 –C 4 alkynyl, (CH 2 ) n aryl, CN, NO 2 , CF 3 , OR 12 , NR 12 R 13 and COOR 12 ; R 10 , R 11 , R 12 and R 13 are independently at each occurrence selected from hydrogen, C 1 –C 4 alkyl or aryl; j is 2–4; n, p, q and t are independently 0–2; R 14 is selected from hydrogen, C 1 –C 4 alkyl, aryl or heteroaryl; or an enantiomer thereof, or a pharmaceutically-acceptable salt thereof.