Patent ID: 6846822

Claim:
A composition comprising a compound of the formula wherein R 1 is selected from the group consisting of H, alkyl and alkylthio of 1 to 6 carbon atoms; R 2 and R 3 are independently H or alkyl; R 4 is H 2 or O, R 5 is selected from the group consisting of H, alkyl of 1 to 6 carbon atoms, alkenyl of up to 6 carbon atoms, cycloakyl, cycloalkylalkyl with alkyl of 1 to 6 carbon atoms, aryl and arylalkyl with alkyl of 1 to 6 carbon atoms, these groups are unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, —O—R 10 , —S(O) m R 10 , m is 0, 1 or 2, —N(R 10 )(R 11 ), —N—C(O)—R 10 , —CO 2 —R 10 , C(O)—N(R 10 )R 11 ), and —(SO 2 )—N(R 10 )(R 11 ); R 6 and R 7 are independently selected from the group consisting of H, —C(O)—NH—CHR 1 —CO 2 R 14 , alkyl of 1 to 6 carbon atoms, aryl and arylalkyl with alkyl of 1 to 6 carbon atoms, these groups being unsubstituted or substituted with a member selected from the group consisting of OH, alkyl and akoxy of 1 to 6 carbon atoms, —N(R 10 )(R 11 ), —COOH, —CON(R 10 )(R 11 ), and halo, or R 6 and R 7 together form aryl or heterocycle; R 8 and R 9 are independently selected from the group consisting of H or 11 to 6 carbon atoms, aryl and arylalkyl with alkyl of 1 to 6 carbon atoms, these groups are unsubstituted or substituted by a member selected from the group consisting of OH, alkyl and alkoxy of 1 to 6 carbon atoms, —N(R 10 )(R 11 ), —CON(R 10 )(R 11 ) and halo, or R 8 and R 9 form together aryl; R 10 and R 11 are independently selected from the group consisting of H, aryl, alkyl of 1 to 6 carbon atoms, arylalkyl; R 12 is —NR 9 —, —S—, or —O—; R 13 is alkyl of 1 to 6 carbon atoms unsubstituted or substituted by a member selected from the group consisting of 1 to 6 carbon atoms, —OR 10 , —S(O) m R 10 , m is 0, 1 or 2, and —N(R 10 )(R 11 ); R 14 is H or alkyl of 1 to 6 carbon atoms; and its pharmaceutically acceptable acid addition salt and at least one other anti-hypertensive agent for the treatment of arterial hypertension.