Patent ID: 7381730

Claim:
A compound of the formula I wherein X is O; A and B are each independently CR′″ or N, wherein A and B are each CR′″, or one of A and B is CR′″ and the of A and B is N; R is H; R′ is H; R 2 is H; R″ is selected from the group consisting of hydrogen, alkyl, benzyl, p-methoxybenzyl, allyl and Si(R 4 ) 3 ; R′″ is selected from the group consisting of hydrogen, halogen, CF 3 , OR 5 , S(O) n R 6 , NR 7 R 8 , cycloalkyl and alkyl; R 1 and R 3 are each independently selected from the group consisting of hydrogen, halogen, CF 3 , OR 5 , S(O) n R 6 , NR 7 R 8 , cycloalkyl and alkyl, wherein alkyl is unsubstituted or is substituted with halo, alkyl, alkoxy, aryl, aryloxy, arylalkyl, arylalkyloxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkyloxy, hydroxyl, hydroxyalkyl, acyl, oxo, alkanoyl, arylalkoxycarbonyl, aryloxyalkyl, aryloxyaryl, alkanoylamino, arylcarbonylamino, nitro, cyano, thiol, haloalkyl, trihaloalkyl or alkylthio; R 4 is a alkyl; R 5 , R 6 , R 7 and R 8 in each functional group are each independently selected from the group consisting of hydrogen, cycloalkyl and alkyl; and n is an integer from 0 to 2, and prodrug esters and pharmaceutically acceptable salts thereof; wherein the term “prodrug esters” refers to esters and carbonates formed by reacting one or more free hydroxyls, that is, where any of R, R′ and/or R″ is H, of the compound of formula I with alkyl, alkoxy, or aryl substituted acylating agents.