Patent ID: 8501056

Claim:
Solvent-free method of producing implants, comprising the steps of: (a) cooling together raw materials comprising at least one pharmaceutically active constituent and at least one polymer compatible therewith, said materials in the form of powders or granules, in a cryogenic mill to a temperature applied in cryogenic technology; (b) completely homogenizing the raw materials together in said mill at a temperature below the glass transition temperature of the at least one polymer; and (c) thereafter bringing the homogenized raw materials to room temperature and obtaining the resulting homogenizate wherein said steps (a) to (c) are carried out in the absence of solvent; and (d) further processing the homogenizate obtained to form an implant; wherein the polymer is selected from one or more in the group consisting of poly(L-lactides), poly(D,L-lactides), poly(D,L-lactides-co-glycolides), and poly(L-lactides-co-D,L-lactides.