Patent ID: 8513283

Claim:
A method of treating cancer in a subject, said method comprising administering an effective amount of a compound of formula I to a patient in need of such treatment wherein R is A is selected from direct bond or —N(R′)—; B is selected from direct bond, O, —N(R′)—, —C(═X)— —C(═X)N(R′)—, lower alkylenyl-C(═X)— or lower alkylenyl-C(═X)N(R′)—; X is selected from O or S; R′ is selected from H, halogen, halogeno-lower alkyl, lower alkyl, hydroxy, lower alkoxy, lower alkoxyalkoxy, lower alkenyl, lower alkynyl, amino, alkylamino, alkoxyamino, cycloalkyl, cycloalkenyl, aryl, lower aryl, heterocyclyl or lower heterocyclyl; R 1 , R 2 and R 3 are each independently selected from H, halogen, halogeno-lower alkyl, lower alkyl, hydroxy, lower alkoxy, lower alkoxyalkoxy, lower alkenyl, or lower alkynyl; R 4 and R 5 are each independently selected from H, halogen, halogeno-lower alkyl, lower alkyl, hydroxy, lower alkoxy, lower alkoxyalkoxy, lower alkenyl, lower alkynyl, lower alkyl-OC(═O)—, aryl-OC(═O)—, aryl lower alkylenyl-OC(═O)—, lower alkyl-C(═O)—, aryl-C(═O)—, aryl lower alkylenyl-C(═O)—, lower alkyl-SO 2 —, ary-SO 2 —, aryl lower alkylenyl-SO 2 —, lower alkyl-C(═O)—, aryl-C(═O)—, aryl lower alkylenyl-C(═O)—, lower alkyl-N(R)C(═O)—, aryl-N(R)C(═O)—, or ary lower alkylenyl-N(R)C(═O)—; R 4 and R 5 connect together to form a 3-8 membered saturated or unsaturated ring with their attached nitrogen; R 6 is selected from H, halogen, halogeno-lower alkyl, lower alkyl; W and Z are each independently selected from O, S, N—R or CH—R; G is selected from C—R, C—(CN) or N; a and c are each independently selected from 0, 1, 2, 3 or 4; b is selected from 1, 2, 3, 4 or 5; and ring Q is selected from following groups: or a pharmaceutically acceptable salt thereof.