Patent ID: 7067662

Claim:
A compound having the formula: wherein {circle around (A)} is optionally independently substituted with one to four R a groups, where each R a is independently selected from the group consisting of halogen, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO 2 , —CO 2 R′, —CONR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″C(O) 2 R′, —NR′—C(O)NR″R′″, —NH—C(NH 2 )═NH, —NR′C(NH 2 )═NH, —NH—C(NH 2 )═NR′, —S(O)R′, —S(O) 2 R′, S(O) 2 NR′R″, —N 3 , —CH(Ph) 2 , perfluoro(C 1 –C 4 )alkoxy, and perfluoro(C 1 –C 4 )alkyl, wherein R′, R″ and R′″ are each independently selected from the group consisting of hydrogen, (C 1 –C 8 )alkyl, (C 2 –C 8 )heteroalkyl, unsubstituted aryl, unsubstituted heteroaryl, (unsubstituted aryl)-(C 1 –C 4 )alkyl, and (unsubstituted aryl)oxy-(C 1 –C 4 )alkyl; L is a member selected from the group consisting of a bond, C(O)—(C 1 –C 8 )alkylene, (C 1 –C 8 )alkylene and (C 2 –C 8 )heteroalkylene; Q is a member selected from the group consisting of a bond, (C 1 –C 8 )alkylene, (C 2 –C 8 )heteroalkylene, —C(O)—, —OC(O)—, —N(R 8 )C(O)—, —CH 2 CO—, —CH 2 SO— and —CH 2 SO 2 —; optionally L and Q can be linked together to form a 5- or 6-membered heterocyclic group having from 1 to 3 heteroatoms; R 1 and R 2 are members independently selected from the group consisting of H, (C 1 –C 8 )alkyl, (C 2 –C 8 )heteroalkyl, aryl and heteroaryl, or optionally are combined to form a 3 to 8-membered ring having from 0 to 2 heteroatoms as ring vertices; R 3 is a member selected from the group consisting of hydroxy, (C 1 –C 8 )alkoxy, amino, (C 1 –C 8 )alkylamino, di(C 1 –C 8 )alkylamino, (C 2 –C 8 )heteroalkyl, (C 3 –C 9 )heterocyclyl, (C 1 –C 8 )acylamino, amidino, guanidino, ureido, cyano, heteroaryl, —CONR 9 R 10 and —CO 2 R 11 ; R 4 is a member selected from the group consisting of (C 1 –C 20 )alkyl, (C 2 –C 20 )heteroalkyl, heteroaryl, aryl, heteroaryl(C 1 –C 6 )alkyl, heteroaryl(C 2 –C 6 )heteroalkyl, aryl(C 1 –C 6 )alkyl and aryl(C 2 –C 6 )heteroalkyl; R 8 is selected from the group consisting of H, (C 1 –C 8 )alkyl, (C 2 –C 8 )heteroalkyl, heteroaryl and aryl; each R 9 , R 10 and R 11 is independently selected from the group consisting of H, (C 1 –C 8 )alkyl, (C 2 –C 8 )heteroalkyl, heteroaryl, aryl, heteroaryl(C 1 –C 6 )alkyl, heteroaryl(C 2 –C 8 )heteroalkyl, aryl(C 1 –C 8 )alkyl and aryl(C 2 –C 8 )heteroalkyl; and R 14 is a member selected from the group consisting of(C 1 –C 8 )alkyl, (C 2 –C 8 )heteroalkyl, aryl(C 1 –C 8 )alkyl, aryl(C 2 –C 8 )heteroalkyl, heteroaryl(C 1 –C 8 )alkyl, heteroaryl(C 2 –C 8 )heteroalkyl, heteroaryl and aryl.