Patent ID: 8470320

Claim:
A humanized antibody comprising a V H binding domain and a V L binding domain wherein the V H binding domain comprises, in sequence, a first framework region (V H FR1), a first CDR (V H CDR1), a second framework region (V H FR2), a second CDR (V H CDR2), a third framework region (V H FR3), a third CDR (V H CDR3) and a fourth framework region (V H FR4), wherein: (i) the sequence of V H FR1 is X 1 VQLQESGPGLVKPSETLSLTCTVX 2 GYSX 3 X 4 (SEQ ID: 95) wherein; X i is Q or E X 2 is S or T X 3 is I, L or V X 4 is S or T; (ii) the sequence of V H CDR1 is SGYSWH (SEQ ID NO: 96); (iii) the sequence of V H FR2 is WIRQX 5 PGKGLX 6 WX 7 G (SEQ ID NO: 97) wherein X 5 is S or P X 6 is Q or E X 7 is M or I; (iv) the sequence of V H CDR2 is HIHX 8 SGRPTYX 9 PSLX 10 S (SEQ ID NO: 98) wherein X 8 is F, Y or W X 9 is N or D X 10 is K, L, H, F, R or S; (v) the sequence of V H FR3 is RX 11 X 12 ISX 13 X 14 TAKNQFSLKLTSMTAADTAVYYCAR (SEQ ID NO: 99) wherein X 11 is V or I X 12 is T or S X 13 is R or K X 14 is E or D; (vi) the sequence of V H CDR3 is KGKGSDDGLNY (SEQ ID NO: 100); (vii) the sequence of V H FR4 is WGQGTLVTVSS (SEQ ID NO: 101).