Patent ID: 7671191

Claim:
A method for preparing a compound of formula A: or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step of: (1) providing 2-iodoadenosine; (2) protecting the hydroxyl groups of said 2-iodoadenosine with an acetonide group; (3) oxidizing, via radical oxidation, the primary alcohol of said acetonide-protected 2-iodoadenosine to an acid derivative of said acetonide-protected 2-iodoadenosine; (4) converting said acid derivative to an N-ethylamide derivative of said acetonide-protected 2-iodoadenosine; (5) deprotecting said N-ethylamide of said acetonide-protected 2-iodoadenosine to form said 2-iodoadenosine-5′-N-ethyluronamide; and (6) contacting said 2-iodoadenosine-5′-N-ethyluronamide with a compound of formula B in the presence of CuI and Pd(PPh 3 ) 2 Cl 2 : wherein Z is —C(═O)OR, where R is a C 1 to C 5 alkyl.