Patent ID: 6906092

Claim:
A method of treating multiple sclerosis, the method comprising administering to a patient having multiple sclerosis a therapeutically effective amount of a compound of Formula I wherein M is a natural (L) alpha amino acid derivative having the structure X is O, S, S(O),S(O) 2 , CH 2 , CO, or NR Q ; R Q is hydrogen, C 1 -C 6 alkyl, or —C 1 -C 6 alkyl-phenyl; R is a side chain of a natural alpha amino acid; R 1 is C 1 -C 5 alkoxy, hydroxy, or —NHOR 5 ; R 2 and R 4 are independently hydrogen, —C 1 -C 5 alkyl, phenyl —NO 2 , halogen, —OR 5 , —CN, —CO 2 R 5 , —SO 3 R 5 , —CHO, —COR 5 , —CONR 5 R 6 , —(CH 2 ) n NR 5 R 6 , —CF 3 , or —NHCOR 5 ; each R 5 and R 6 are independently hydrogen or C 1 -C 5 alkyl; and n is 0 to 2, and the pharmaceutically acceptable salts, esters, and amides thereof, wherein the esters thereof are selected from C 1 -C 6 alkyl esters, C 5 -C 7 cycloalkyl esters, and arylalkyl esters and the amides thereof are derived from ammonia, primary C 1 -C 6 alkyl amines, secondary C 1 -C 6 dialkyl, and 5- and 6-membered hererocyclic amines containing one nitrogen atom; and wherein the group S(═O) 2 M is optionally bonded to the 1-, 2-, or 3-position of Formula I.