Patent ID: 8604183

Claim:
A composition comprising first and second chemically synthesized oligomeric compounds, wherein: the first oligomeric compound is fully complementary to and capable of hybridizing with said second oligomeric compound and to a selected nucleic acid target; at least one of said first and second oligomeric compounds comprises a contiguous sequence of linked nucleosides wherein the sequence defines an alternating motif having the formula: 5′-Q(-L-Z-L-Q) n (-L-Z) nn -3′ wherein: each L is an internucleoside linking group; each Q is a nucleoside having a 2′-F substituent group and each Z is a β-D-deoxyribonucleoside; or each Q is β-D-deoxyribonucleoside and each Z is a nucleoside having a 2′-F substituent group; n is from about 8 to about 14 and nn is 0 or 1; and each of said oligomeric compounds is from 12 to 30 linked nucleosides in length.