Patent ID: 7173057

Claim:
A compound, or enantiomers, stereoisomers, rotamers, tautomers, and racemates of said compound, or a pharmaceutically acceptable salt, solvate or ester of said compound, said compound having the general structure shown in Formula I: wherein: R 1 is H, OR 8 , NR 9 R 10 , or CHR 9 R 10 , wherein R 8 , R 9 and R 10 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, aryl-, heteroalkyl-, heteroaryl-, cycloalkyl-, heterocyclyl-, arylalkyl-, and heteroarylalkyl; A and M are connected to each other (in other words, A-E-L-M taken together) such that the moiety: shown above in Formula I forms either a three, four, six, seven or eight-membered cycloalkyl, E is C(H) or C(R); L is C(H) or C(R); R, R 2 , and R 3 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, cycloalkyl-, heteroalkyl-, heterocyclyl-, aryl-, heteroaryl-, (cycloalkyl)alkyl-, (heterocyclyl)alkyl-, aryl-alkyl-, and heteroaryl-alkyl-; and Y is selected from the following moieties: wherein G is NH or O, and R 15 , R 17 , R 18 , R 19 and R 20 can be the same or different, each being independently selected from the group consisting of H, C 1 â€“C 10 alkyl, C 1 â€“C 10 heteroalkyl, C 2 â€“C 10 alkenyl, C 2 â€“C 10 heteroalkenyl, C 2 â€“C 10 alkynyl, C 2 â€“C 10 heteroalkynyl, C 3 â€“C 8 cycloalkyl, C 3 â€“C 8 heterocyclyl, aryl, heteroaryl, or alternately: (i) R 15 and R 19 are connected to each other to form a five to eight-membered cycloalkyl or heterocyclyl, or R 15 and R 20 are connected to each other to form a five to eight-membered cycloalkyl or heterocyclyl, and (ii) likewise, independently, R 17 and R 18 are connected to each other to form a three to eight-membered cycloalkyl or heterocyclyl, wherein each of said alkyl, aryl, heteroaryl, cycloalkyl or heterocyclyl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of: hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, amido, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, sulfonamido, alkylsulfonamido, arylsulfonamido, keto, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halo, cyano, and nitro and wherein any carbon or heteroatom with unsatisfied valances in the text, schemes, examples and tables herein is assumed to have hydrogen atom(s) to satisfy the valences.