Patent ID: 8524456

Claim:
A method for detecting the presence of cancer cells that express the 16C3 human colorectal and pancreatic carcinoma-associated antigen (CPAA) in a subject comprising (a) administering to said subject a labeled monoclonal antibody or fragment thereof, that binds the 16C3 CPAA and (b) detecting the presence of human carcinoma-associated protein antigen specifically bound by said antibody, wherein the presence of said human carcinoma-associated protein antigen is indicative of carcinoma cells that express the 16C3 CPAA; and wherein said antibody comprises a light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 4, a CDR2 comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 5, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 6; and said antibody comprises a heavy chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO: 7, a CDR2 comprising the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 10 and a CDR3 comprising the amino acid sequence of SEQ ID NO: 9 or SEQ ID NO: 11.