Patent ID: 8497076

Claim:
A method for identifying a subject with pre-diabetes or diabetes, comprising: determining a first glycosylation profile of a first sample from the subject, wherein the first glycosylation profile comprises one or more parameters relating to glycosylation; and comparing the first glycosylation profile to a second glycosylation profile of a second sample from a control subject, wherein the second glycosylation profile comprises one or more parameters relating to glycosylation, wherein the control subject does not have pre-diabetes or diabetes; wherein determining the glycosylation profile of the first and second samples comprises measuring binding of Aleuria aurantia lectin, Datura stramonium lectin, Phaseolus vulgaris agglutinin lectin, Concanavalin A , and Sambucus nigra lectin to the first and second samples; and wherein an increase in binding of Aleuria aurantia lectin, Datura stramonium lectin, and Phaseolus vulgaris agglutinin lectin to the first sample relative to the second sample indicates that the subject has either pre-diabetes or diabetes; and wherein an increase in binding of Aleuria aurantia lectin, Datura stramonium lectin, Phaseolus vulgaris agglutinin lectin, Concanavalin A , and Sambucus nigra lectin to the first sample relative to the second sample indicates that the subject has diabetes, and not pre-diabetes.