Patent ID: 8163701

Claim:
A compound of structural Formula: or salts thereof wherein: X is an opioid, an amphetamine, or a phenidate and X is covalently bonded to —(CR 2 R 3 )—via an amine, a phenol, a carboxylic acid or a thiol; R 2 and R 3 are independently hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; R k 16 are each independently selected from the group consisting of one or more of —F, —Cl, —Br, —I, —R 4 , —O − , —OR 4 , —SR 4 , —S − , —NR 4 R 5 , —CF 3 , —CN, —OCN, —SCN, —NO, —NO 2 , —N 3 , —S(O) 2 O − , —S(O) 2 OH, —S(O) 2 R 4 , —OS(O 2 )O − , —OS(O) 2 R 4 , —P(O)(O − ) 2 , —P(O)(OR 4 )(O − ), —OP(O)(OR 4 )(OR 5 ), —C(O)R 4 , —C(S)R 4 , —C(O)OR 4 , —C(O)NR 4 R 5 , —C(O)O − , —C(S)OR 4 , —NR 6 C(O)NR 4 R 5 , —NR 6 C(S)NR 4 R 5 , —NR 7 C(NR 6 )NR 5 R 4 and —C(NR 6 )NR 5 R 4 , and k is 0, 1, 2, 3, or 4; R 4 , R 5 , R 6 and R 7 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, or optionally R 4 and R 5 together with the nitrogen atom to which they are bonded form a cycloheteroalkyl or substituted cycloheteroalkyl ring; R 8 is hydrogen or methyl; R 12 is an amino acid side chain; each U is independently —NR 13 —, —O—or —S—; each R 13 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl or optionally, R 13 and R 14 together with the atoms to which they are bonded form a cycloheteroalkyl or substituted cycloheteroalkyl ring; and R 14 is hydrogen, acyl, or —CO 2 —t—butyl; and o is an integer from 1 to 5.