Patent ID: 8618107

Claim:
A compound selected from Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R 1 is H, D, F, Cl, CN, â€”NH 2 , â€”NHCH 3 , â€”N(CH 3 ) 2 , â€”OH, â€”OCH 3 , â€”OCH 2 CH 3 , â€”OCH 2 CH 2 OH, heteroaryl selected from imidazolyl and pyrazolyl, heterocyclyl selected from oxetanyl and azetidinyl, and C 1 -C 3 alkyl; R 2 , R 3 and R 4 are independently selected from H, D, F, Cl, â€”NH 2 , â€”NHCH 3 , â€”N(CH 3 ) 2 , â€”OH, â€”OCH 3 , â€”OCH 2 CH 3 , â€”OCH 2 CH 2 OH, and C 1 -C 3 alkyl; R 5 is optionally substituted C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, C 2 -C 20 heterocyclyl, C 1 -C 20 heteroaryl, â€”(C 6 -C 20 aryl)-(C 2 -C 20 heterocyclyl), â€”(C 1 -C 20 heteroaryl)-(C 2 -C 20 heterocyclyl), â€”(C 1 -C 20 heteroaryl)-(C 1 -C 6 alkyl), or â€”(C 1 -C 20 heteroaryl)-C(â•O)â€”(C 2 -C 20 heterocyclyl); R 6 is H, F, â€”NH 2 , â€”OH, or optionally substituted C 1 -C 3 alkyl; X is S, S(â•O), S(â•O) 2 , N, NR 6 , O, or CR 7 ; R 7 is independently selected from H, D, F, Cl, â€”CH 3 , â€”CH 2 CH 3 , â€”CN, â€”CH 2 F, â€”CHF 2 , â€”CF 3 , â€”NH 2 , â€”OH, and â€”OCH 3 ; Y 1 and Y 2 are independently selected from CR 6 and N; Z 1 , Z 2 , Z 3 , and Z 4 are independently selected from C, CR 7 , and N; Z 5 is â€”CR 3 â•Nâ€”; one of Z 1 and Z 2 , or X and Z 1 , where X is not S, S(â•O), or S(â•O) 2 , forms a five-, six-, or seven-membered aryl, carbocyclyl, heterocyclyl or heteroaryl ring; where alkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from D, F, Cl, Br, I, â€”CH 3 , â€”CH 2 CH 3 , â€”CH 2 CH(CH 3 ) 2 , â€”CH 2 OH, â€”CH 2 CH 2 OH, â€”C(CH 3 ) 2 OH, â€”CH(OH)CH(CH 3 ) 2 , â€”C(CH 3 ) 2 CH 2 OH, â€”CH 2 CH 2 SO 2 CH 3 , â€”CH 2 OP(O)(OH) 2 , â€”CN, â€”CH 2 F, â€”CHF 2 , â€”CF 3 , â€”CO 2 H, â€”COCH 3 , â€”CO 2 CH 3 , â€”CO 2 C(CH 3 ) 3 , â€”COCH(OH)CH 3 , â€”CONH 2 , â€”CONHCH 3 , â€”CON(CH 3 ) 2 , â€”C(CH 3 ) 2 CONH 2 , â€”NO 2 , â€”NH 2 , â€”NHCH 3 , â€”N(CH 3 ) 2 , â€”NHCOCH 3 , â€”N(CH 3 )COCH 3 , â€”NHS(O) 2 CH 3 , â€”N(CH 3 )C(CH 3 ) 2 CONH 2 , â€”N(CH 3 )CH 2 CH 2 S(O) 2 CH 3 , â•O, â€”OH, â€”OCH 3 , â€”OCH 2 CH 2 N(CH 3 ) 2 , â€”OP(O)(OH) 2 , â€”S(O) 2 N(CH 3 ) 2 , â€”SCH 3 , â€”CH 2 OCH 3 , â€”S(O) 2 CH 3 , cyclopropyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, oxetanyl, and morpholino.