Patent ID: 8124779

Claim:
A process for preparing esomeprazole non-salt form comprising the following steps: i) dissolving a base addition salt of esomeprazole in water containing at least one amine B 1 selected from the group consisting of ammonia, triethylamine, methylamine, ethylenediamine, ethanolamine, diethanolamine, trimethylamine, diethylamine and dimethylamine; ii) adding at least one acid from selected from the group consisting of citric acid, sodium bicarbonate, carbonic acid, hydrochloric acid and acetic acid; and iii) allowing esomeprazole non-salt form to crystallize and isolating the formed crystals, wherein the esomeprazole non-salt form is selected from the group consisting of esomeprazole form B, esomeprazole form C, esomeprazole form E and esomeprazole form G.