Patent ID: 6849657

Claim:
A compound represented by Formula I: wherein: Q is CH 2 or oxygen; B is —CH 2 —, —(CH 2 ) 2 —, —(CH 2 ) 3 —, —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CH═CH—, —CH 2 —CH═CH—, —CH═CH—CH 2 —, or —CH 2 —CH═CH—CH 2 —, provided that when B is —CH═CH— or —CH═CH—CH 2 —, then; X is —NR a — (where R a is hydrogen, halogen, (C 1 -C 6 )alkyl or (C 1 -C 6 )acyl), —O—, —S—, —SO— or —SO 2 — or a single bond, provided that when X is a single bond, then Q is oxygen; J is —(CR b R c ) n — (where n is an integer from 1 to 4, and R b and R c are both hydrogen or one or two of R b and R c are lower alkyl and the remainder are hydrogen, or R b and R c if attached to the same carbon atom form a C 2 -C 5 -polymethylene group) or —CH 2 —CH═CH—; A is —CH 2 —CH 2 —, —CH═CH—, or —CΞC—; Z is CH 2 OH, —C(O)OR′, —C(O)NR′R″, —C(O)NSO 2 R′, —P(C 1 -C 6 )alkyl(O)(OR′), (—PO(OR′) 2 , or tetrazol-5-yl; wherein R′ and R″ are independently from each other hydrogen or (C 1 -C 6 )alkyl; n is 1, 2, 3 or 4; R 1 is —(CH 2 ) p R 7 or —(CH 2 ) q OR 8 , wherein R 7 and R 8 are each independently from each other (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, heterocyclyl, aryl or heteroaryl; p and q are each independently from each other 0, 1, 2, 3, 4, or 5; R 2 is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl, or (C 1 -C 6 )alkyl; and R 3 , R 4 , R 5 and R 6 are independently from each other hydrogen or (C 1 -C 6 )alkyl; or a pharmaceutically acceptable salt or solvate, prodrug, single isomer or racemic or non-racemic mixture of isomers thereof.