Patent ID: 7550457

Claim:
A method for treating a vascular disease or vascular disorder comprising administering to a patient in need thereof an effective amount of a compound of formula III as defined below: wherein R 1 and R 2 are independently hydrogen, straight chained C 1-6 alkyl group optionally substituted with a phenyl group, branched C 1-6 alkyl group optionally substituted with a phenyl group, or R 1 and R 2 together with the nitrogen atom attached thereto form a 5-7 membered saturated heterocyclic ring optionally containing further nitrogen and/or oxygen heteroatom, wherein said heterocyclic ring is optionally substituted with one or more hydroxy, oxo or benzyl groups; A is a phenyl group optionally substituted with one or more C 1-4 alkyl, C 1-4 haloalkyl, nitro, or halogen, or is a 5-6 membered heteroaromatic ring containing at least one heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur, wherein the nitrogen heteroatom is optionally an N-oxide structure; n is 0, 1, or 2; z is 0 or 1; with the proviso that if R 1 and R 2 independently represent a hydrogen atom, a straight chained C 1-6 alkyl group optionally substituted with a phenyl group, a branched C 1-6 alkyl group optionally substituted with a phenyl group, or together with the nitrogen atom attached thereto form a 5-7 membered saturated heterocyclic ring optionally containing further nitrogen and/or oxygen heteroatom, then A is a heteroaromatic ring containing oxygen or sulfur heteroatom or an N-containing heteroaromatic ring having an N-oxide structure on the nitrogen heteroatom and if A is a phenyl group optionally substituted with one or more C 1-4 alkyl, C 1-4 haloalkyl or nitro groups or halogen, or is a 5-6 membered N-containing heteroaromatic ring, then R 1 and R 2 together with the nitrogen atom attached thereto form a 5-7 membered saturated heterocyclic ring optionally containing further nitrogen and/or oxygen heteroatom, wherein said heterocyclic ring is substituted with one or more hydroxy, oxo, or benzyl groups; or a stereoisomer or salt thereof.