Patent ID: 7485651

Claim:
A method of treating the symptoms of a disease or condition associated with increased intraocular pressure, said method comprising administering to a patient in need of such treatment, a therapeutically effective amount of a muscarinic receptor agonist of formula (I): wherein R 1 is straight or branched-chain C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkylidene, C 1-8 alkoxy, C 2-8 heteroalkyl, C 1-8 aminoalkyl, C 1-8 haloalkyl, C 1-8 alkoxycarbonyl, C 1-8 hydroxyalkoxy, C 1-8 hydroxyalkyl, —SH, C 1-8 alkylthio, —O—CH 2 phenyl, —C(O)—phenyl substituted with C 1-3 alkyl or piperidine, t is 0 or 1; R 2 is H, amino, hydroxyl, halo, or straight or branched-chain C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 heteroalkyl, C 1-6 aminoalkyl, C 1-6 haloalkyl, C 1-6 alkoxycarbonyl, C 1-6 alkylthio, —CN, —CF 3 , NO 2 , or piperidine; n is 0, 1, 2, 3 or 4, the groups R 2 , when n>1, being the same or different; p is 0 or an integer from 1 to 5; Z is absent or CR 8 R 9 wherein R 8 and R 9 are independently selected from H, and straight or branched-chain C 1-8 alkyl; or a pharmaceutically acceptable salt thereof.