Patent ID: 8470822

Claim:
A compound having the formula wherein X and Y are each independently selected from the group consisting of halo, R 2 , OR 2 , SR 3 , and NR 4 R 5 ; U and W are each —N═; V is —(R 6′ )C═ or —(R 6′ )C(R 7′ )—; Q is selected from the group consisting of C and CH; T is selected from the group consisting of S, O, N and —C═C— such that the ring structure of which T is a member is aromatic; A 1 and A 2 are each independently selected from the group consisting of —C(S)—, —C(Z)O—, —OC(Z)—, —N(R 4″ )—, —C(Z)—N(R 4″ )—, —N(R 4″ )—C(Z), —O—C(Z)—N(R 4″ )—, —N(R 4″ )—C(Z)—O—, —N(R 4″ )—C(Z)—N(R 5″ )—, —O—, —S—, —S(O)—, —S(O) 2— , —N(R 4″ )S(O) 2— , —C(R 6″ )(R 7″ )—, —N(C≡CH)—, —N(CH 2 —C≡CH)—, C 1 -C 12 alkyl and C 1 -C 12 alkoxy; where Z is oxygen or sulfur provided that A 2 does not represent —C(O)NH—; R 1 is selected from the group consisting of hydrogen, halo, C 1 -C 12 alkyl, and C 1 -C 12 alkoxy; R 2 , R 3 , R 4 , R 4′ , R 4″ , R 5 , R 5″ , R 6″ and R 7″ are each independently selected from the group consisting of hydrogen, halo, C 1 -C 12 alkyl, C 1 -C 12 alkoxy, C 1 -C 12 alkanoyl, C 1 -C 12 alkenyl, C 1 -C 12 alkynyl, (C 1 -C 12 alkoxy)carbonyl, and (C 1 -C 12 alkylamino)carbonyl; R 6 and R 7 are each independently selected from the group consisting of hydrogen, halo, C 1 -C 12 alkyl, and C 1 -C 12 alkoxy; or R 6 and R 7 are taken together to form O═; R 6′ and R 7′ are each independently selected from the group consisting of hydrogen, halo, C 1 -C 12 alkyl, and C 1 -C 12 alkoxy; or —R 6′ and R 7′ are taken together to form O═; L is a divalent linker; n, p, r and s are each independently either 0 or 1 provided when n=1, then r=1; and B is a leaving group; provided that the linker L does not include a naturally occurring amino acid covalently linked to A 2 at it's a-amino group through an amide bond.