Patent ID: 7592021

Claim:
A bioadhesive aqueous pharmaceutical formulation for controlled, transmucosal delivery of a beneficial agent, comprising: (a) from 0.5 wt % to no more than 5 wt % total pH-responsive polycarbophils, wherein the polycarbophils exhibit base-dependent bioadhesiveness; (b) from 0.5 wt % to no more than 5 wt % total temperature-responsive alkylene oxide copolymers, wherein the alkylene oxide copolymers exhibits reverse thermal gelation; (c) a base in an amount sufficient for the pH of the formulation to be in the range of about 5 to about 7, thereby imparting bioadhesiveness of the pH-responsive polycarbophils; and (d) an effective amount of a beneficial agent; wherein the formulation has a sol-gel phase transition temperature between about 30° C. and about 40° C., is bioadhesive, and provides controlled, transmucosal delivery of the beneficial agent.