Patent ID: 7312334

Claim:
A method of preparing a compound of preparing a compound of the formula IX and Formula IXa: comprising Step C: reacting, in solvent A, a compound of Formula Va wherein R 1 is selected from the group consisting of C 1-8 alkyl, aryl, and heteroaryl; optionally substituted with aryl and/or C 1-8 alkyl, solvent A is dimethylaminoacetamide, dimethylformamide, acetonitrile, DMSO, methylacetamide, ethers or mixtures thereof; with a compound of Formula VII or Formula VIIa in the presence of a palladium catalyst and a phosphine ligand in amine base to yield a compound of Formula VIII or Formula VIIa Step D: reacting, in solvent B, a compound of Formula VIII or VIIIa with cyclopropylamine optionally in the presence of a catalyst to yield a compound of Formula IX or IXa.