Patent ID: 8871802

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: n is 0-4; m is 0-2; X is O or S; each R 1 is independently halogen; —NO 2 ; —CN; —OR; —SR; —N + (R) 3 ; —N(R) 2 ; —C(O)R; —CO 2 R; —C(O)C(O)R; —C(O)CH 2 C(O)R; —S(O)R; —S(O) 2 R; —C(O)N(R) 2 ; —SO 2 N(R) 2 ; —OC(O)R; —N(R)C(O)R; —N(R)N(R) 2 ; —N(R)C(═NR)N(R) 2 ; —C(═NR)N(R) 2 ; —C═NOR; —N(R)C(O)N(R) 2 ; —N(R)SO 2 N(R) 2 ; —N(R)SO 2 R; —OC(O)N(R) 2 ; or an optionally substituted group selected from C 1-12 aliphatic; a 3- to 14-membered carbocycle; a 3- to 14-membered heterocycle; a 6- to 14-membered aryl ring; or a 5- to 14-membered heteroaryl ring, or: two R 1 groups on adjacent carbon atoms are taken together with their intervening atoms to form an optionally substituted ring selected from 3- to 14-membered carbocycle; 3- to 14-membered heterocycle; a 6- to 14-membered aryl ring; or a 5- to 14-membered heteroaryl ring; each R 2 , R 3 , and R 4 is independently hydrogen; halogen; —NO 2 ; —CN; —OR; —SR; —N + (R) 3 ; —N(R) 2 ; —C(O)R; —CO 2 R; —C(O)C(O)R; —C(O)CH 2 C(O)R; —S(O)R; —S(O) 2 R; —C(O)N(R) 2 ; —SO 2 N(R) 2 ; —OC(O)R; —N(R)C(O)R; —N(R)N(R) 2 ; —N(R)C(═NR)N(R) 2 ; —C(═NR)N(R) 2 ; —C═NOR; —N(R)C(O)N(R) 2 ; —N(R)SO 2 N(R) 2 ; —N(R)SO 2 R; —OC(O)N(R) 2 ; or an optionally substituted group selected from C 1-12 aliphatic; a 3- to 14-membered carbocycle; a 3- to 14-membered heterocycle; a 6- to 14-membered aryl ring; or a 5- to 14-membered heteroaryl ring; R′ is —S(O)R 5 ; —S(O) 2 R 5 ; or —NO 2 , wherein when m is O, R′ is —S(O)R 5 or —S(O) 2 R 5 ; R 5 is —OR; —SR; —N(R) 2 ; or an optionally substituted group selected from C 1-12 aliphatic; a 3- to 14-membered carbocycle; a 3- to 14-membered heterocycle; a 6- to 14-membered aryl ring; or a 5- to 14-membered heteroaryl ring; and each R is independently hydrogen or an optionally substituted group selected from C 1-12 aliphatic; a 3- to 14-membered carbocycle; a 3- to 14-membered heterocycle; a 6- to 14-membered aryl ring; or a 5- to 14-membered heteroaryl ring; wherein when m is 1 or 2, each double bond independently has Z or E stereochemistry; Provided that either R 3 or R 4 is not hydrogen when R′ is —NO 2 ; Further provided that R 2 is not methyl when R′ is —S(O) 2 OH.