Patent ID: 8629156

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: A is optionally substituted biphenyl X is —O—, —C(R 3 R 4 )O—, or —OC(R 3 R 4 )—; E is optionally substituted aryl or heterocycle; R 1 is hydrogen or optionally substituted alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; R 2 is hydrogen or optionally substituted alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; R 3 is hydrogen, alkoxy, amino, cyano, halogen, hydroxyl, or optionally substituted alkyl; R 4 is hydrogen, alkoxy, amino, cyano, halogen, hydroxyl, or optionally substituted alkyl or aryl; each R 10 is independently amino, cyano, halogen, hydrogen, OR 11 , NR 12 R 13 , or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; each R 11 is independently hydrogen or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; each R 12 is independently hydrogen or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; each R 13 is independently hydrogen or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; n is 0-3; and q is 1-2.