Patent ID: 7943297

Claim:
A diagnostic method of monitoring therapeutic efficacy of an antiretroviral therapy in an acquired immunodeficiency virus-infected patient undergoing the antiretroviral therapy, comprising: (a) obtaining from the virus-infected patient a population of acquired immunodeficiency virus; (b) determining the proportion of the viral population using a CXCR4 coreceptor; and (c) determining the proportion of the viral population using a CCR5 coreceptor, wherein the proportion of the viral population using the CXCR4 coreceptor and the proportion of the viral population using the CCR5 coreceptor, is determined by obtaining virus envelope gene V3 region sequence(s), whereby the antiretroviral therapy is determined to be therapeutically effective when the proportion of the viral population using the CXCR4 coreceptor is lower than the proportion of the viral population using the CCR5 coreceptor.