Patent ID: 8507683

Claim:
A compound of formula I where: R 1 is phenyl or pyridinyl and is substituted with 0-3 substituents selected from the group consisting of halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkoxy, hydroxyalkyloxy, and alkoxyalkyloxy, and is also substituted with 1 CON(R 9 )(R 10 ) substituent; R 2 is hydrogen, halo, or alkyl; R 3 is CONHCH 3 ; R 4 is phenyl that is independently substituted with 0-2 halo or methoxy or is para substituted with X—Ar 1 ; R 5 and R 6 are independently hydrogen, alkyl, halo, N(R 7 )(R 8 ), or alkylsulfonyl; R 7 and R 8 are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, alkylsulfonyl, or alkylsulfonylalkyl; or N(R 7 )(R 8 ) taken together is azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, and is substituted with 0-2 substituents selected from alkyl, hydroxyalkyl, or hydroxy; R 9 is hydrogen; R 10 is R 11 and R 12 taken together is —CH 2 OCH 2 —, —OCH 2 CH 2 —, —CH 2 OCH 2 CH 2 —, —OCH 2 CH 2 CH 2 —, —OCH 2 CH 2 CH 2 CH 2 —, —CH 2 OCH 2 CH 2 CH 2 —, —CH 2 CH 2 OCH 2 CH 2 — (thus forming an oxetanyl, dihydrofuranyl, or dihydropyranyl ring); X is —O— or —NH—; Ar 1 is phenyl or para-halophenyl; and Ar 2 is phenyl, pyridinyl, pyrazolyl, isoxazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, oxadiathiazolyl, triazolyl, tetrazolyl, pyrazinyl, or pyrimidinyl, and is substituted with 0-3 substituents selected from halo, alkyl, or dialkylamino; or a pharmaceutically acceptable salt thereof.