Patent ID: 7589115

Claim:
A method for treating an inflammatory condition selected from the group consisting of: adult respiratory distress syndrome, shock, oxygen toxicity, multiple organ injury syndrome secondary to septicemia, multiple organ injury syndrome secondary to trauma, reperfusion injury of tissue due to cardiopulmonary bypass, myocardial infarction, acute glomerulonephritis, vasculitis, reactive arthritis, dermatosis with acute inflammatory components, stroke, thermal injury, hemodialysis, leukapheresis, ulcerative colitis, necrotizing enterocolitis, granulocyte transfusion associated syndrome, psoriasis, organ/tissue transplant rejection, graft vs. host reaction, Raynaud's syndrome, autoimmune thyroiditis, dermatitis, multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, uveitis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, asthma and toxic effects of cytokine therapy, in a patient which comprises administering to said patient a therapeutically effective amount of a compound of the formula I: wherein: R 1 is straight or branched alkyl of 1 to 3 carbon atoms which is optionally mono- or disubstituted with oxo; R 2 and R 3 are each independently selected from the group consisting of: (A) hydrogen, and (B) straight or branched alkyl of 1 to 4 carbon atoms which alkyl group is mono- or disubstituted with moieties independently selected from the group consisting of: (i) CONH 2 and (ii) OH, and R 4 is pyrimidine which is mono- or disubstituted with NH 2 or or a pharmaceutically acceptable salt thereof.