Patent ID: 8859781

Claim:
A compound, or pharmaceutically acceptable salt, or solvate of a compound or salt, of Formula (I): wherein: R 1 is selected from the group consisting of H, OH, alkyl and alkyl-O—; X is O or S; -L- is C 1-15 alkylene, wherein each of one, two or three —CH 2 — radicals is optionally replaced with a radical selected from the group consisting of: n is 0, 1, 2, 3 or 4; R 2 is selected from the group consisting of H, alkyl, aryl, heterocyclyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, carboxyalkyl and hydroxyalkyl; each of R 3 and R 4 is independently selected from the group consisting of H, alkyl, aryl and heterocyclyl, or R 3 is taken together with R 4 to form a carbocyclic ring having 3 to 7 ring atoms including optionally one or more O, N, or S atoms as ring atoms; Z is selected from the group consisting of phthalimido, succinimido, wherein phthalimido or succinimido is optionally substituted by halo, alkyl, alkyl-O, aryl and heteroaryl; R 5 is selected from the group consisting of alkyl, aryl, heterocyclyl and aralkyl; each of R 6 and R 16 is independently selected from the group consisting of H, alkyl, hydroxy, aminoalkyl, acylamino, amido, carboxy, carboxyalkyl, hydroxyalkyl, cycloalkyl, aryl, heterocyclyl, aralkyl, alkyl-O—, alkyl-S— and alkyl-NH—, or each of R 6 and R 16 is independently taken together with R 2 , R 7 or R 8 to form a nitrogen-containing heterocyclyl ring having 3, 4, 5 or 6 ring-carbon atoms; and each of R 7 and R 8 is independently selected from the group consisting of H, alkyl, hydroxyalkyl, aryl, heterocyclyl, alkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, carboxyalkylcarbonyl, alkyloxycarbonylalkylcarbonyl, alkylsulfonyl, arylsulfonyl and heteroarylsulfonyl, or R 7 is taken together with R 2 , R 6 or R 8 to form a nitrogen-containing heterocyclyl ring having 3, 4, 5 or 6 ring-carbon atoms.