Patent ID: 8633318

Claim:
A method for the treatment of inflammation, an inflammatory disease, an immune or an autoimmune disorder, which comprises administering to a mammal, in need of such treatment an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, geometrical isomer, tautomer, optical isomer or N-oxide thereof, wherein: R 1 is one, two or three substituents independently selected from halogen, cyano, C 1-6 -alkyl, halo-C 1-6 -alkyl and C 1-6 -alkoxy; R 2 is a 4- to 7-membered saturated or partially saturated heterocyclic ring containing, 1 or 2 heteroatoms independently selected from O, S and N(R 3 ), and wherein ring carbon atoms are optionally substituted with R 4 ; R 3 is selected from hydrogen, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, cyano-C 1-6 -alkyl, halo-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, C 1-6 -acyl and C 1-6 -alkylsulfonyl; R 4 is selected from halogen, hydroxy, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, cyano-C 1-6 -alkyl, halo-C 1-6 -alkyl, and C 1-6 -alkoxy; and a is 0, 1 or 2; provided that the compound is not: 3-(3,4-dichlorophenyl)-1-(1-methylpiperidin-4-yl)-1H-pyrazolo[4,3-c]pyridine, or 1-(1-methylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[4,3-c]pyridine.