Patent ID: 8883773

Claim:
A compound of the formula: or an ester, a protected compound at the amino on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, wherein X is —N═, —CH═, —C(—R 5 )═, —C(—Br)═ or —C(—Cl)═; R 5 is lower alkyl or halo(lower)alkyl; W is —CH 2 —, —S— or —O—; U is —CH 2 —, —S— or —O— when W is —CH 2 —, or U is —CH 2 — when W is —S— or —O—; R 1 and R 2 are each independently hydrogen atom, halogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted carbocyclic group or optionally substituted heterocyclic group; or R 1 and R 2 taken together with a neighboring atom may form an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Q is a single bond, optionally substituted carbocyclic group, or an optionally substituted heterocyclic group; ring A is a 6-membered aromatic heterocyclic group having 1 nitrogen atom; R 3 is hydrogen atom, —OCH 3 or —NH—CH(═O); k is an integer from 0 to 2; m is an integer from 0 to 2; each R 4 is independently hydrogen atom, halogen, hydroxy, —CN, —C(═O)—R 6 , —C(═O)—OH, or —OR 6 ; R 6 is lower alkyl or halo(lower)alkyl; with regard to D and E, a) D is a single bond, —N(R 8 )— or —R 7 —N(R 8 )— wherein R 7 is an optionally substituted lower alkylene and R 8 is a hydrogen or lower alkyl, and E is an optionally substituted cyclic group selected from the following formulae (1) to (8), (10), (11), (13), (15) and (25) to (31); or b) D is the formula: wherein q is 0 or 1, and E is a group of formula (10) or (41) in the following formulae: wherein p is an integer from 1 to 3; and R X is an optionally substituted lower alkyl.