Patent ID: 7655695

Claim:
A compound having formula (I) wherein R 1 is —C(X 1 )X 2 (R 9 ) or H; X 1 is O, or S; X 2 is O, S, or N(R 10 ); R 2 is hydrogen, —C(═O)(C 1 -C 6 )alkyl, —C(═O)(C 1 -C 6 )alkyl(C 6 -C 10 )aryl, —C(═O)(C 6 -C 10 )aryl, or —(C 1 -C 6 )alkyl; R 3 is hydrogen, or (C 1 -C 6 )alkyl; R 4 is hydrogen, —SCH 2 CO 2 (C 1 -C 6 )alkyl, —O—(C 6 -C 10 )aryl, or —S—(C 6 -C 10 )aryl; where aryl is optionally substituted with halo, OH or (C 1 -C 4 )alkyl; R 5 is hydrogen, OH, or absent; R 6 is hydrogen, or (C 1 -C 6 )alkyl; and R 7 is OH or Si((C 1 -C 4 )alkyl) 3 ; or R 6 and R 7 together are ethylenedioxy; R 8 is (C 1 -C 6 )alkyl; optionally substituted with OH or halo; R 9 is hydrogen, (C 1 -C 6 )alkyl, —(C 1 -C 4 )alkyl(C 6 -C 10 )aryl, or —(C 6 -C 10 )aryl; or —(C 1 -C 4 )alkyl(C 6 -C 10 )heteroaryl, or —(C 6 -C 10 )heteroaryl; R 10 is hydrogen or (C 1 -C 6 )alkyl; n is 1, 2, 3, 4, 5, or 6; and the bond represented by — is optionally present or absent; or pharmaceutically acceptable salts thereof.