Patent ID: 7811814

Claim:
A method of delivering a first nucleic acid to a nervous system cell in a patient with a nervous system disorder, the method comprising: providing a recombinant adeno-associated viral (rAAV) vector, the vector comprising: SEQ ID NO: 20 operably linked to a first nucleic acid encoding a protein that provides a therapeutic effect on the nervous system disorder; a second nucleic acid encoding a tetracycline-controlled transactivator; inverted terminal repeats of AAV; and a tetracycline-off regulatable promoter system comprising a first promoter operably linked to the first nucleic acid and a second promoter operably linked to the second nucleic acid, wherein the first and second promoters drive expression in opposite directions in the vector, towards each other and away from the inverted terminal repeats, and wherein expression of a product from the first nucleic acid is regulatable by the promoter system; and administering the rAAV vector to the nervous system cell.