Patent ID: 7579367

Claim:
A compound having the Formula I: or a pharmaceutically acceptable salt thereof, wherein: Ar is Ar 4 , wherein Ar 4 is R 1 is C(O)R 10 ; R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, alkenyl, or alkynyl, halogen, hydroxy, cycloalkyl, cyano, amino, alkylamino, dialkylamino, alkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, and aralkylcarbonylamino; provided that 1) the pyridyl ring is other than 2,6-disubstituted with regard to Ar and R 1 or any of R 2 -R 4 that is other than hydrogen; R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido and alkylthiol; R 9 is an optionally substituted alkyl; R 10 is selected from the group consisting of amino and optionally substituted heterocycloalkylamino; and X is one of O, S, NH, or absent (a covalent bond); with the proviso that: 2) when X is O or absent and R 1 is aminocarbonyl, then R 9 is not a straight chain alkyl group optionally mono-substituted with halogen, carboxy, alkoxy, an optionally substituted phenyl, or an optionally substituted aminocarbonyl.