Patent ID: 8481550

Claim:
A method for treating lung cancer or colorectal cancer in a patient in need thereof, comprising administering to the patient a compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: X is —NH— or —O—; R a is hydrogen or —OH; R c is hydrogen or —OH; W is —NH—, —N(R 1 )— or —O—, wherein R 1 is C 1-4 aliphatic; one of D and E is —N═ and the other is —C(R h )═; each R h is independently hydrogen, halo or C 1-4 aliphatic; R 8 is hydrogen or C 1-4 aliphatic; each R p is independently halo or C 1-4 aliphatic; each R 8p is independently halo; C 1-4 aliphatic optionally substituted with —OR 5x or —C(O)—N(R 4x )(R 4y ), wherein R 5x is hydrogen or C 1-4 alkyl, R 4x is hydrogen or C 1-4 alkyl, and R 4y is hydrogen or C 1-4 alkyl; —OR 5x wherein R 5x is hydrogen or C 1-4 alkyl; or —C(O)—N(R 4x )(R 4y ) wherein R 4x is hydrogen or C 1-4 alkyl and R 4y is hydrogen or C 1-4 alkyl; s is 0, 1 or 2; and t is 0, 1 or 2.