Patent ID: 7557244

Claim:
A compound having the general Formula (I) wherein A is O, NH, S; X is a bond or a group —CR 5 R 6 wherein R 5 and R 6 are, independently of each other, selected from the group consisting of H; alkyl selected from the group CH 3 , C 2 H 5 , i-C 3 H 7 , n-C 3 H 7 , i-C 4 H 9 , n-C 4 H 9 , sec-C 4 H 9 , tert-C 4 H 9 ; alkenyl selected from C 2 H 3 , i-C 3 H 5 , n-C 3 H 5 , n-C 4 H 7 , i-C 4 H 7 , sec-C 4 H 7 ; wherein in any of the alkyl or alkenyl groups one or more H atoms optionally can be substituted with one or more substituents independently selected from the group consisting of OH, F, Cl, Br, I and CF 3 ; or R 5 , R 6 may jointly form together with the carbon atom to which they are attached a ring, either saturated or unsaturated, substituted or unsubstituted, having 3 to 6 C-atoms, and which may contain in the ring one or more heteroatoms from the group N, S or O, and which heteroatom may be identical or different if more than one heteroatom is present; R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of H; F; Cl; Br; I; CN; OH; C(O)N(R 7 R 8 ); S(O) 2 R 7 ; SO 2 N(R 7 R 8 ); S(O)N(R 7 R 8 ); N(R 7 )S(O) 2 R 8 ; N(R 8 )S(O)R 8 ; S(O) 2 R 7 ; N(R 7 )S(O) 2 N(R 8 R 8a ); SR 7 ; N(R 7 R 8 ); N(R 7 )C(O)R 8 ; N(R 7 )C(O)N(R 8 R 8a ); N(R 7 )C(O)OR 8 ; OC(O)N(R 7 R 8 ); C(O)R 7 ; substituted and unsubstituted C 1 -C 4 -alkyl and substituted and unsubstituted C 1 -C 4 -alkoxy, and wherein the substituents of both groups C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy are selected from F, Cl, Br, I, CF 3 ; R 7 , R 8 , R 8a are independently selected from the group consisting of H; C 1 -C 4 -alkyl; heterocyclyl; and C 3-7 cycloalkyl, wherein C 1 -C 4 -alkyl; heterocyclyl; and C 3-7 cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I and CF 3 ; Y is a carboxy group —C(O)OH or a substututed or unsubstituted tetrazole group; R 9 , and R 10 are independently H, F, or CF 3 ; and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof.