Patent ID: 7358043

Claim:
A method of correlating protein-protein interaction(s) involved in one or more pathophysiological processes or one or more physiological processes with oxygen tension comprising (a) screening for a protein-protein interaction between at least one protein and a plurality of proteins, where the screening is performed in room air, and where the plurality of proteins are screened concurrently; (b) screening for a protein-protein interaction between the at least one protein and a plurality of proteins, where the screening is performed in the presence of decreased oxygen tension from that in room air, where the oxygen tensions employed in step (b) range from 0.1 mm Hg to 145 mm Hg, and where the plurality of proteins are screened concurrently; and (c) correlating the protein-protein interaction(s) with oxygen tension by identifying at least one different protein-protein interaction between (a) and (b), wherein the at least one different protein-protein interaction between (a) and (b) is involved in one or more pathophysiological processes or one or more physiological processes.