Patent ID: 7718663

Claim:
A quinazoline derivative represented by general formula (1b) or a salt thereof: wherein R 1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A 1 and A 2 are the same or different and each represents a single bond or an alkylene group; R 2 represents a hydrogen atom or alkyl; A 3 represents A 31 -A 32 -A 33 , A 31 and A 33 are the same or different and each represents a single bond, or a divalent saturated or unsaturated aliphatic hydrocarbon group having 1to 6 carbon atoms which may have the same or different 1 or 2 substituents at a substitutable position; wherein the substituents are selected from alkyl, alkoxy, phenyl, alkoxyalkyl, alkoxycarbonyl, dialkylamino, and oxo; or when one carbon atom has two branched chains, the branched chains may be taken together with the carbon atom to form divalent cycloalkyl; A 32 represents a single bond, an oxygen atom, a sulfur atom, or —N(R 32 )—, wherein R 32 represents a hydrogen atom or alkyl; R 3 represents an optionally substituted non-cyclic aliphatic hydrocarbon group having 1 to 8 carbon atoms, wherein the substituents are selected from alkyl, hydroxy, alkoxy, phenyl, alkoxy-substituted phenyl, halogen-substituted phenyl, hydroxy-substituted phenyl, phenoxy, alkylthio, carboxy, alkoxycarbonyl, acyl, amino, monoalkylamino, dialkylamino, acyl amino, alkylsulfonyl, alkylsulfonylamino, phenylsulfonyl, oxo, cyano, trifluoromethyl, benzoyl, benzyloxycarbonyl, benzylthio and imidazol-4-yl; an optionally substituted cyclic aliphatic hydrocarbon group having 3 to 10 carbon atoms which is mono- to tricyclic, wherein the substituents are selected from alkyl, alkynyl, alkoxy, alkoxycarbonyl, carbamoyl, aryl, alkoxyalkyl, acyl and oxo, and wherein the cyclic aliphatic hydrocarbon group may be fused with 1 or 2 benzene rings; or an optionally substituted aromatic hydrocarbon group having 6 to 12 carbon atoms which is mono- or dicyclic, wherein the substituents are selected from alkyl, arylalkyl, arylalkenyl, alkenyl, cinnamyl, alkoxy, phenyl, phenoxy, acyl, acylamino, alkoxycarbonyl, amino, aminoalkyl, monoalkylamino, dialkylamino, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino, phenylsulfonyl, oxo, cyano, nitro, aminosulfonyl, halogen, trifluoromethyl, trifluoromethoxy, alkylthio, 1H-pyrrol-1-yl, 5-oxo-4,5-dihydro-1H-pyrazol-1-yl and aminosulfonyl; or the —N(R 2 )— may be taken together with -A 3 -R 3 to form a mono- to tricyclic amino group; wherein the mono- to tricyclic amino group may have the same or different 1 to 3 substituents selected from the group consisting of alkyl, alkoxy, alkoxyalkyl, acyl, acylamino, alkoxycarbonyl, carbamoyl, monoalkylcarbamoyl, dialkylcarbamoyl, aryl optionally substituted with alkoxy, arylalkyl, arylalkenyl, piperidino, pyridyl, pyrimidinyl, pyrazinyl, and 1,3-benzodioxol-5-ylmethyl; provided that R 3 is not an optionally substituted phenyl group; and R 4 and R 5 are the same or different and each represents a hydrogen atom, alkyl, alkoxy or halogen.