Patent ID: 8686184

Claim:
A compound of formula I: where: R 1 is â€”OR 10 or â€”NR 60 R 70 ; R 2 is H or â€”OR 20 ; R 3 is selected from Cl, F, â€”CH 3 , and â€”CF 3 ; a is 0 or an integer from 1 to 3; R 4 is selected from â€”C 1-6 alkyl; â€”C 3-7 cycloalkyl; â€”C 0-2 alkylene-COOR 40 ; â€”NR 41 R 42 ; â€”NHC(O)Oâ€”C 1-6 alkyl; â€”NHC(O)R 43 ; â€”NHC(O)NHâ€”R 44 ; phenyl substituted with one or two groups independently selected from halo, â€”Oâ€”C 1-6 alkyl, â€”C 0-1 alkylene-COOR 40 , â€”SO 2 NH 2 , â€”C(O)NR 41 R 42 , and tetrazole; and â€”C 0-2 alkylene-C 1-9 heteroaryl or a partially unsaturated â€”C 0-2 alkylene-C 3-5 heterocycle both optionally substituted with 1-3 groups independently selected from halo, â€”OH, â•O, â€”CHO, â€”C 1-6 alkyl, â€”CF 3 , and â€”COOR 40 ; R 5 is selected from H, halo, â€”OH, â€”C 1-6 alkyl, â€”Oâ€”C 1-6 alkyl, phenyl, and morpholine; R 6 is H or halo; R 10 and R 40 are independently selected from H, â€”C 1-6 alkyl, â€”C 1-3 alkylene-C 6-10 aryl, â€”C 1-3 alkylene-C 1-9 heteroaryl, â€”C 3-7 cycloalkyl, â€”[(CH 2 ) 2 O] 1-3 CH 3 , â€”C 1-6 alkylene-OC(O)R 13 , â€”C 1-6 alkylene-NR 14 R 15 , â€”C 1-6 alkylene-C(O)R 17 , â€”C 0-6 alkylenemorpholine, â€”C 1-6 alkylene-SO 2 â€”C 1-6 alkyl, R 13 is selected from â€”C 1-6 alkyl, â€”Oâ€”C 1-6 alkyl, â€”C 3-7 cycloalkyl, â€”Oâ€”C 3-7 cycloalkyl, phenyl, â€”O-phenyl, â€”NR 14 R 15 , and â€”CH(NH 2 )CH 2 COOCH 3 ; R 14 and R 15 are independently selected from H, â€”C 1-6 alkyl, and benzyl, or R 14 and R 15 are taken together as â€”(CH 2 ) 3-6 â€”, â€”C(O)â€”(CH 2 ) 3 â€”, or â€”(CH 2 ) 2 O(CH 2 ) 2 â€”; R 16 is â€”C 1-6 alkyl or â€”C 0-6 alkylene-C 6-10 aryl; R 17 is selected from â€”Oâ€”C 1-6 alkyl, â€”O-benzyl, and â€”NR 14 R 15 ; R 20 is H or is taken together with R 10 to form â€”CR 21 R 22 â€” or is taken together with R 60 to form â€”C(O)â€”; R 21 and R 22 are independently selected from H, â€”C 1-6 alkyl, and â€”Oâ€”C 3-7 cycloalkyl, or R 21 and R 22 are taken together to form â•O; R 43 is selected from â€”C 1-6 alkyl, â€”C 1-3 alkylene-COOR 40 , phenyl, and pyridine; R 44 is selected from â€”C 1-6 alkyl, â€”C 1-6 alkylene-COOR 40 , phenyl, and thiophene-COOR 40 , where thiophene is optionally substituted with CH 3 ; R 60 is selected from H, â€”OH, â€”OC(O)R 61 , â€”CH 2 COOH, â€”O-benzyl, pyridyl, and â€”OC(S)NR 62 R 63 ; R 61 is selected from H, â€”C 1-6 alkyl, â€”C 6-10 aryl, â€”OCH 2 â€”C 6-10 aryl, â€”CH 2 Oâ€”C 6-10 aryl, and â€”NR 62 R 63 ; R 70 is selected from H, â€”C 1-6 alkyl, and â€”C(O)R 71 ; R 71 is selected from H, â€”C 1-6 alkyl, â€”C 3-7 cycloalkyl, â€”C 6-10 aryl, and â€”C 1-9 heteroaryl; R 41 , R 42 , R 62 , and R 63 are independently H or â€”C 1-4 alkyl; or a pharmaceutically acceptable salt thereof.