Patent ID: 7364910

Claim:
A method of combined treatment for stimulating follicular development and ovulation induction in a female host comprising: (a) administering an agent which increases follicle stimulating hormone concentrations or has follicle stimulating hormone function and activity in the host during the follicular phase of the host's ovulatory cycle; and (b) administering an inhibitor of a phosphodiesterase 4 isoform to the host prior to the luteal phase of the host's ovulatory cycle, wherein the inhibitor of a phosphodiesterase 4 isoform is selected from the group consisting of: cis-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl) cyclohexane-1-carboxylic acid; 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide; 2-(4-(6,7-diethoxy-2,3bis(hydroxymethyl)napthalen-1-yl)pyridin-2-yl)-4-(3-pyridyl)pthalazin-1 (2H)-one hydrochloride; and 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine; roflumilast and arofylline.