Patent ID: 8236858

Claim:
A method for treating a disease, disorder or condition selected from the group consisting of Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, multiple sclerosis, Alzheimer's disease, diabetes, schizophrenia, or depression, which method comprises administering to an animal or human in need of such treatment an effective amount of a compound of the formula: wherein R1 is alkylsulfonyl; each of R2 and R3 is independently selected from hydrogen, carboxy, nitro, alkylsulfonyl, aminosulfonyl, alkyl aminosulfonyl, halogen, cyano, C1-4 alkyl, C1-4 alkoxy, NR′R″, aryl, aryl-C1-4 alkyl, or aryl-C1-4 alkoxy, and each of R′ and R″ is independently H or C1-4 alkyl, or R′═R″═C1CH2CH2, or NR′R″ constitutes a saturated heterocyclic ring containing 3-8 ring members; X is: —(CH2) n -Y— wherein Y is: >NH; n is 0-4; and any carbon of the —(CH2)n- may be substituted by 1-2 substituents independently selected from halogen, carboxy, C1-4 alkyl, C1-4 alkoxy, OH, NH2 or acyl; and Ar is a kynurenine/kynuramine metabolite of a 3-indole: wherein each R5 independently is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, OH, NR′R″ as defined above, nitro, aryl, aryl-C1-4 alkyl, or aryl-C1-4 alkoxy; or a pharmaceutically acceptable salt thereof.