Patent ID: 7041690

Claim:
A compound of formula 1: wherein: X represents a covalent bond or is selected from the group NR 2 , S, O, C═O, C(R 2 )(R′ 2 ), CF 2 , CCl 2 , CR 2 OR′ 2 , CR 2 NR′ 2 , SO, and SO 2 ; Y is selected from the group substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heteroalkyl; Z is selected from the group substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; any two adjacent substiuents of Y or Z may be taken together to form a fused carbocyclic or heterocyclic ring of 5 to 7 members; R 1 is selected from the group H, alkyl, hetero-C 1 –C 8 -alkyl, halogen, CN, halo C 1 –C 8 -alkyl, aryl, heteroaryl, cyclo-C 1 –C 8 -alkyl and ara-C 1 –C 8 -alkyl; R 2 is H, C 1 –C 8 -alkyl, C 1 –C 8 -alkenyl, hetero C 1 –C 8 alkyl, C 1 –C 8 cycloalkyl, heterocyclo C 1 –C 8 alkyl, aryl, ara C 1 –C 8 alkyl, heteroaryl or heteroaralkyl; R 3 is selected from the group H, OH, OR2, N(R 2 )(R′ 2 ) and N(R 2 )-T-W where T represents a substituted or unsubstituted alkyl or cycloalkyl group of 1–8 carbons; W is selected from the group OH, N(R 2 )(R′ 2 ), CON(R 2 )(R′ 2 ), OCON(R 2 )(R′ 2 ), NCON(R 2 )(R′ 2 ) and CO 2 R 2 ; A represents a substituted or unsubstituted heteroaromatic ring of 5 or 6 members; the substituents X and R1-double bond (R 1 C═) are connected to A in a 1,2 1,3 or 1,4 spatial relationship; and the substituents A and COR 3 have an E (trans) configuration with respect to the double bond to which they are attached.