Patent ID: 8895057

Claim:
A method for effecting weight loss in a patient having a body mass index of at least 25 kg/m 2 , comprising administering an escalating unit dosage form comprising, (a) a first dosage form, comprising, 23 mg of topiramate, formulated for controlled release, and 3.75 mg of phentermine, formulated for immediate release, wherein the first dosage form is administered to the subject daily for at least 2 weeks; and (b) a second dosage form, comprising, 46 mg of topiramate, formulated for controlled release, and 7.5 mg of phentermine, formulated for immediate release, wherein the topiramate formulated for controlled release reaches maximum plasma concentration (Cmax) at about 6 to about 10 hours (Tmax) after administration and exhibits a lower Cmax, than non-controlled release topiramate, without decreasing total drug exposure defined by the area under the concentration-time curve (AUC), and wherein the second dosage form is administered to the subject daily for at least 2 years, thereby effecting weight loss.