Patent ID: 7795273

Claim:
A compound of the formula wherein R1 is hydrogen, halo, sulfamoyl, N—C 1-4 alkyl sulfamoyl, N,N-di-C 1-4 alkyl sulfamoyl, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted heterocyclyl; each of R2 and R3 is, independency of the other, hydrogen, halo, C 1-4 -alkyl, trifluoromethyl, C 1-4 -alkoxy or cyano, X 1 , X 2 , X 3 and X 4 are CH; D is N(R6), O or S, wherein R6 is hydrogen, acyl or unsubstituted or substituted alkyl, Y 1 is O, S, NH, CH 2 , N═CH, CH═N or CH═CH; Y 2 is C or, if Ra is absent, can be N; Ra is absent if Y 2 is N and R1 is unsubstituted alkyl with 5 or more carbon atoms, substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted heterocyclyl, or, if Y 2 is C, is hydrogen if R1 is unsubstituted alkyl with 5 or more carbon atoms, substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted heterocyclyl, or, if Y 2 is C and R1 is hydrogen, halo, C 1-4 -alkyl, sulfamoyl, N—C 1-4 alkyl sulfamoyl, N,N-di-C 1-4 alkyl sulfamoyl, or unsubstituted aryl, is a moiety of the formula wherein the dotted line means the bond binding to the rest of the molecule of the formula I (which is indicated by the wave line), A is C(═O)—N(R4) or N(R4)-C(═O), wherein R4 is hydrogen or unsubstituted or substituted alkyl, Z 1 is O, S, NH, CH 2 , CH═N, N═CH or CH═CH, Z 2 is nitrogen or CH, Z 3 is CH or N, each R 5 present is, independency of the others, a substituent and n is 0, 1 or 2, in free form or in salt form.