Patent ID: 8153660

Claim:
A compound of formula 1 wherein R 1 is H, halogen or OR 1.1 ; R 1.1 H or C 1-6 -alkyl; R 2 is C 1-6 -alkyl, C 3-8 -cycloalkyl, C(R 2.1 ) 2 OR 2.1 or C(R 2.1 ) 2 N(R 2.1 ) 2 ; R 2.1 H, C 1-6 -alkyl or C 3-8 -cycloalkyl; R 3 is CN, C 1-6 -alkyl-COR 3.2 , C 2-6 -alkenyl-COR 3.2 , C 1-6 -alkyl-O—R 3.3 , C 1-6 -alkyl-N(R 3.3 ) 2 , SO 2 Ph, phenyl substituted by one, two or three R 3.1 or benzyl optionally substituted by one, two or three R 3.1 ; R 3.1 is C 1-6 -alkyl-COR 3.1.1 , C 3-8 -cycloalkyl-COR 3.1.1 , NHCOR 3.1.3 , CON(R 3.1.2 ) 2 , or C 1-6 -alkyl-CON(R 3.1.2 ) 2 ; R 3.1.1 is OH, OC 1-6 -alkyl, NHC 1-6 -alkyl, N(C 1-6 -alkyl) 2 or het, optionally substituted with a carbonyl group; R 3.1.2 is H or R 3.1.3 ; R 3.1.3 is C 1-6 -alkyl or C 3-8 -cycloalkyl, optionally substituted with halogen, COOR 3.1.3.1 , COR 3.1.3.1 , CON(R 3.1.3.1 ) 2 , N(R 3.1.3.1 ) 2 , NR 3.1.3.1 SO 2 R 3.1.3.1 , OR 3.1.3.1 , SR 3.1.3.1 , SOR 3.1.3.1 , SO 2 R 3.1.3.1 or SO 2 N(R 3.1.3.1 ) 2 ; R 3.1.3.1 is H, C 1-6 -alkyl or C 3-8 -cycloalkyl; R 3.2 is OH, OC 1-6 -alkyl, NHC 1-6 -alkyl, N(C 1-6 -alkyl) 2 or het, optionally substituted with a carbonyl group; R 3.3 is H, C 1-6 -alkyl-COR 3.3.1 , C 3-8 -cycloalkyl-COR 3.3.1 , CONHR 3.3.2 , CON(R 3.3.2 ) 2 or C 1-6 -alkyl-CONHR 3.3.2 R 3.3.1 is OH, OC 1-6 -alkyl, NHC 1-6 -alkyl, N(C 1-6 -alkyl) 2 or het, optionally substituted with a carbonyl group; R 3.3.2 is H or R 3.3.3 ; R 3.3.3 is C 1-6 -alkyl or C 3-8 -cycloalkyl, optionally substituted with halogen, COOR 3.3.3.1 , COR 3.3.3.1 , CON(R 3.3.3.1 ) 2 , N(R 3.3.1 ) 2 , NR 3.3.3.1 SO 2 R 3.3.3.1 , OR 3.3.3.1 , SR 3.3.3.1 , SOR 3.3.3.1 , SO 2 R 3.3.3.1 or SO 2 N(R 3.3.3.1 ) 2 ; R 3.3.3.1 is H, C 1-6 -alkyl or C 3-8 -cycloalkyl; D is CR 4 or N R 4 is H or halogen; and pharmaceutically acceptable salts thereof.