Patent ID: 7659403

Claim:
A compound of formula Ic: wherein: a is 0 or 1; R 1 is halo; b is 0 or 1; R 2 is halo; m is 0 or 1; Z 1 is selected from —C(O)N(R 4 )— and —N(R 4 )C(O)—, where R 4 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; n is 0 or 1; Ar 1 represents a phenylene group; wherein the phenylene group is substituted with (R 5 ) p where p is 0 or an integer from 1 to 4 and each R 5 is independently selected from halo, hydroxy, (1-4C)alkyl, and (1-4C)alkoxy; q is 0 or 1; Z 2 is selected from —C(O)N(R 6 )— and —N(R 6 )C(O)—, where R 6 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; r is 0, 1 or 2; Y′ is where: R 12 is selected from hydrogen, (1-4C)alkyl, -(1-4C)alkyleneOH, and -(1-4C)alkyleneheteroaryl; and R 13 is selected from (1-4C)alkyl, -(1-4C)alkyleneOH, -(1-4C)alkyleneheteroaryl, (3-6C)cycloalkyl, -(1-4C)alkylene(3-6C)cycloalkyl, and -(1-4C)alkyleneC(O)NR 13a R 13b , where R 13a and R 13b are independently hydrogen or (1-4C)alkyl; wherein each alkyl and alkoxy group in R 5 is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.