Patent ID: 8571804

Claim:
A method of identifying drug candidates for the combinatorial treatment of a selected disease, the method comprising the steps of: a) building a dynamic model of a selected disease in silico comprising: (i) performing multivariate genetic, proteomic and metabolomics statistical analysis of groups of genes and establishing disease-associated pathways involved in disease genesis and progression, said disease-associated pathways being targets for drug development; (ii) testing data of (i) on whole pathway association and validating results in another data set; and (iii) organizing emerging pathways in a hierarchical model and defining the most relevant mechanisms or cell targets by which the disease may be corrected; b) in silico screening of drugs approved for other diseases that target pathways implicated in the model and selecting at least two drugs which interact concurrently with several different target pathways implicated in the dynamic model; c) testing drugs selected in b) in an in vitro and/or in vivo biological model of the selected disease to select biologically active drugs; and d) identifying from drugs selected in c) a drug combination having a synergistic effect for the treatment of said selected disease, at doses lower than those approved for said other diseases.