Patent ID: 8193377

Claim:
A compound for inhibiting proteasome having the formula: wherein R 5 is selected from the group consisting of —H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 7 cycloalkyl, phenyl, benzyl and C 3 -C 7 cycloalkenyl, wherein each of the C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 7 cycloalkyl, phenyl, benzyl and C 3 -C 7 cycloalkenyl can be substituted with any combination of one to six halogen atoms; and wherein the formula satisfies one of the following conditions (1) to (6): (1) each of R 11 , R 2 , and R 4 is —H, and each of R 12 , R 13 , R 21 , R 22 , and R 3 is a benzoate group; (2) each of R 11 , R 13 , R 2 , and R 4 is —H, and each of R 12 , R 21 , R 22 , and R 3 is an acetate group; (3) each of R 11 , R 13 , R 2 , and R 4 is —H, and each of R 12 , R 21 , R 22 , and R 3 is a benzoate group; (4) each of R 11 and R 13 is —H, and each of R 12 , R 21 , R 22 , R 2 , R 3 , and R 4 is an acetate group; (5) wherein R 5 is —H, each of R 11 , R 12 , R 13 , R 21 , and R 22 is an acetate group, R 2 is an acetate group, and each of R 3 and R 4 is —H; or (6) wherein R 5 is —H, each of R 11 , R 12 , R 13 , R 21 , and R 22 is an acetate group, each of R 2 and R 4 is an acetate group, and R 3 is —H.