Patent ID: 7417040

Claim:
A compound of formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt thereof, wherein the symbols have the following meanings and are, for each occurrence, independently selected: Y is —C(═O)— or —S(═O) 2 —; X 1 X 2 is —CR 1 ═CR 3 —, —CR 1 R 2 —CR 3 R 4 —, —C(═O)—CR 3 R 4 —, or —CR 1 R 2 —C(═O)—; R 2 , R 4 , R 6 and R 10 are each independently hydrogen, halogen, cyano, nitro, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, aryl or substituted aryl, OR a , SR a , S(═O)R e , S(═O) 2 R e , S(═O) 2 OR e , NR b R c , NR b S(═O) 2 R e , S(═O) 2 NR b R c , C(═O)OR e , C(═O)R a , C(═O)NR b R c , OC(═O)R a , OC(═O)NR b R c , NR b C(═O)OR e , NR d C(═O)NR b R c , NR d S(═O) 2 NR b R c , or NR b C(═O)R a , wherein: R 2 and R 4 together may optionally form a 3-7 membered optionally substituted carbocyclic ring or 3-7 membered optionally substituted heterocyclic ring; R a is hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, or aryl or substituted aryl; R b , R c and R d are independently hydrogen, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, heterocycle or substituted heterocycle, or aryl or substituted aryl, or said R b and R c together with the N to which they are bonded optionally form a heterocycle or substituted heterocycle; R e is alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, or aryl or substituted aryl; R 1 and R 3 are each independently hydrogen, cyano, nitro, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, heterocycle or substituted heterocycle, aryl or substituted aryl, OR a , SR a , S(═O)R e , S(═O) 2 R e , C(═O)OR e , C(═O)R a , NR b R c , NR b C(═O)R a , NR b C(═O)OR e , C(═O)NR b R c , OC(═O)R a , or OC(═O)NR b R c , wherein R 1 and R 3 together may optionally form a 3-7 membered optionally substituted carbocyclic ring or 3-7 membered optionally substituted heterocyclic ring; R 9 is H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, aryl or substituted aryl, OR e , or NR b R c ; m is 1-4; and n is 1-4; provided that: at least one of R 6 and R 10 is not H; and when X 1 X 2 is —CH 2 —CH 2 —, R 9 is not H, aryl or substituted aryl, or heteroaryl or substituted heteroaryl.