Patent ID: 8524895

Claim:
A method for preparing an amide, comprising the steps of: catalyzing Beckman rearrangement of a ketoxime to produce an amide in the presence of a catalyst, wherein the catalyst is an N-substituted amino acid ionic liquid having a cation represented by the following formula (I) and one or more anions selected from the group consisting of inorganic acid ions, organic acid ions and a combination thereof: wherein R 1 is hydrogen, cycloimino, or C 1 -C 8 alkyl, in which the C 1 -C 8 alkyl is unsubstituted or substituted by a substituent selected from the group consisting of hydroxyl (—OH), carboxyl (—COOH), guanidino (NH 2 C(═NH)NH—), amino (—NH 2 ), amido (RCONH—), hydroxyphenyl, C 1 -C 8 alkylthio, thiol (—SH), C 6 -C 10 aryl and 5- to 10-membered heteroaryl; and R 2 and R 3 are independently hydrogen or C 1 -C 8 alkyl, in which the C 1 -C 8 alkyl is unsubstituted or substituted by a substituent selected from the group consisting of carboxyl (—COOH), sulfo (—SO 3 H), chlorosulfinyl (ClSO—), ester group (—COOR, wherein R is C 1 -C 8 alkyl), oxo (═O) and C 6 -C 10 aryl, provided that R 2 and R 3 are not hydrogen concurrently, wherein the numbers of the anion and the cation are such that the N-substituted amino acid ionic liquid is electroneutral.