Patent ID: 8859552

Claim:
A compound of Formula 1: or a pharmaceutically acceptable salt, isomer, racemate, diastereomeric mixture thereof, wherein: A is —(CH 2 ) n —, —O—(CH 2 ) n —, —S—(CH 2 ) n —, —S(O)(O)—(CH 2 ) n —, —NH—(CH 2 ) n —, —CH 2 —O—(CH 2 ) n —, —(CH 2 ) n —O—CH 2 —CH 2 —, —CH 2 —S—(CH 2 ) n —, —(CH 2 ) n —S—CH 2 —CH 2 —, —CH 2 —S(O)(O)—(CH 2 ) n —, —(CH 2 ) n —S(O)(O)—CH 2 —CH 2 —, —O—C(O)—(CH 2 ) n —, —S—C(O)—(CH 2 ) n —, —NH—C(O)—(CH 2 ) n —, —CH 2 —C(O)—O—(CH 2 ) n —, —CH 2 —C(O)—NH—(CH 2 ) n —, —CH 2 —C(O)—S—(CH 2 ) n —, —(CH 2 ) n —C(O)—O—CH 2 —CH 2 —, —(CH 2 ) n —C(O)—NH—CH 2 —CH 2 —, —(CH 2 ) n —C(O)—S—CH 2 —CH 2 —, —CH 2 —O—C(O)—(CH 2 ) n —, —CH 2 —NH—C(O)—(CH 2 ) n —, —CH 2 —S—C(O)—(CH 2 ) n —, —(CH 2 ) n —O—C(O)—CH 2 —CH 2 —, (CH 2 ) n —NH—C(O)—CH 2 —CH 2 —, or (CH 2 ) n —S—C(O)—CH 2 —CH 2 —, wherein n is an integer from 1 to 7; B is NR 5 ; and R 1 , R 2 , R 3 , R 4 , R 5 ,R 6 , R 7 , and R 8 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, acylalkyloxycarbonyl, acyloxyalkyloxycarbonyl, acylalkyloxycarbonylamino, acyloxyalkyloxycarbonylamino, alkoxy, alkoxycarbonyl, alkoxycarbonylalkoxy, alkoxycarbonylalkylamino, alkylsulfinyl, alkylsulfonyl, alkylthio, amino, alkylamino, arylalkylamino, dialkylamino, arylalkoxy, arylalkoxycarbonylalkoxy, arylalkoxycarbonylalkylamino, aryloxycarbonyl, aryloxycarbonylalkoxy, aryloxycarbonylalkylamino, carboxy, carbamoyl, carbamate, carbonate, cyano, halogen, heteroaryloxycarbonyl, hydroxy, phosphate, phosphonate, sulfate, sulfonate, or sulfonamide; wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 and R 8 and A are optionally substituted with isotopes selected from the group consisting of 2 H (deuterium), 3 H (tritium), 13 C, 36 Cl, 18 F, 15 N, 17 O, 18 O, 31 P, 32 P, and 35 S.