Patent ID: 7589091

Claim:
A compound of Formula I wherein R 1 is lower alkyl, C 3 -C 8 cycloalkyl, C 3 -C 18 heterocycloalkyl or C 4 -C 18 aryl each of which is independently optionally substituted by hydroxy, halogen, lower alkoxy, C 3 -C 8 cycloalkyl-lower alkoxy, or C 4 -C 18 aryl-lower alkoxy; X is halogen, cyano, lower alkyl, halo-substituted lower alkyl, C 4 -C 18 aryl, C 4 -C 18 aryl-lower alkyl, hydroxy, —OR 5 , SR 5 or —NR 6 R 7 , each of which is optionally substituted by halogen, hydroxy, lower alkoxy, C 3 -C 6 cycloalkyl-lower alkoxy, or C 4 -C 18 aryl-lower alkoxy wherein R 5 is hydrogen, lower alkyl, C 3 -C 8 cycloalkyl, C 3 -C 18 heterocycloalkyl or C 4 -C 18 aryl and R 6 and R 7 are independently H, lower alkyl, C 3 -C 8 cycloalkyl, C 3 -C 18 heterocycloalkyl or C 4 -C 18 aryl; Z is —CH 2 —, —CHR 8 —, —O—, —S—, or —N(R 8 )— wherein R 8 is H, lower alkyl, C 3 -C 8 cycloalkyl, C 3 -C 18 heterocycloalkyl, C 4 -C 18 aryl lower alkoxycarbonyl or C 4 -C 8 aryloxycarbonyl, each of which is independently optionally substituted by halogen, hydroxy, lower alkoxy, C 3 -C 6 cycloalkyl-lower alkoxy, or C 4 -C 8 aryl-lower alkoxy; A is hydrogen, —CR 10 R 11 -Q-R 12 , —C(O)-Q-R 12 or —C(S)-Q-R 12 wherein R 10 and R 11 are independently H, lower alkyl, C 3 -C 8 cycloalkyl, C 3 -C 18 heterocycloalkyl or C 4 -C 18 aryl each of which is independently optionally substituted by halogen, hydroxy, lower alkoxy, C 3 -C 6 cycloalkyl-lower alkoxy, or C 4 -C 18 aryl-lower alkoxy, Q is —NR 8 —, —S— or —O—, where R 8 is as defined above, and R 12 is lower alkyl C 3 -C 8 cycloalkyl, C 4 -C 18 aryl, C 4 -C 18 aryl-lower alkyl, each optionally substituted by hydroxy, halogen, lower alkoxy, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkoxy, C 4 -C 18 aryl or C 4 -C 18 aryl-lower alkoxy; and R 3 and R 4 is Hydrogen or lower alkyl; and n is 0 or 1, or a pharmaceutically-acceptable and -cleavable ester thereof or acid addition salts thereof.