Patent ID: 7211695

Claim:
A process for preparing a compound of formula (II′): wherein Ar 1 and Ar 3 are independently selected from phenyl, 4-hydroxy-3-hydroxymethylphenyl, 4-hydroxy-3-(HCONH-)phenyl, 3,5-dichloro-4-aminophenyl, and or a protected derivative thereof; wherein the stereochemistry at *C is (R), (S), or (RS); W is alkylene; Ar 2 is 1,4-phenylene; X is a bond; Q is —N(R z )—CH 2 —**CH(OH)-, wherein the stereochemistry at **C is (R), (S), or (RS); and R x and R z are each hydrogen or R x and R z are each PG 1 , wherein PG 1 is an amino protecting group; or a salt thereof; the process comprising: (a) deprotecting a compound of formula (II′) wherein Ar 1 or Ar 3 are protected derivatives; (b) deprotecting a compound of formula (II′) wherein R x and R z are each PG 1 ; (c) (i) reacting a compound of formula (1): with a compound of formula (2): H 2 N—W—Ar 2 —NH 2 (2) to form a reaction mixture; (ii) adding a compound of formula (1′): to the reaction mixture of step (c)(i); then adding a reducing agent; (d) reacting a compound of formula (1) with a compound of formula (a): then adding a reducing agent; (e) reacting a compound of formula (a) with a compound of formula (b): (f) when Ar 1 and Ar 3 are the same, reacting a compound of formula (1) with a compound of formula (2); then adding a reducing agent; and for steps (a), (b), (c), (d), (e), and (f), optionally removing any protecting groups; to provide a compound of formula (II′) or a salt thereof.