Patent ID: 8796470

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein α is a single bond; R 1 is —N(R x )C(O)G 3 ; R a and R b , at each occurrence, are each independently hydrogen, alkyl, arylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, or OR 1a ; wherein the aryl of arylalkyl is unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen; R 1a is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, or haloalkyl; wherein said aryl, the aryl of arylalkyl, cycloalkyl and the cycloalkyl of cycloalkylalkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen; R x is hydrogen or alkyl; R 2a is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, or haloalkyl; wherein said aryl, the aryl of arylalkyl, cycloalkyl, and the cycloalkyl of cycloalkylalkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen; R 2b is alkyl or haloalkyl; G 3 , at each occurrence, is independently aryl or heteroaryl; wherein G 3 at each occurrence is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, N(R 2a ) 2 , N(R 2a )C(O)R 2a , OR 2a , C(O)R 2a , C(O)OR 2a , C(O)N(R 2a ) 2 , SO 2 R 2b , and SO 2 N(R 2a ) 2 ; m, at each occurrence, is independently 1, 2, 3, 4, 5, or 6; R 2 is alkyl, haloalkyl, G 3 or —(CR a R b ) m -G 3 ; R 3 is hydrogen, alkyl, haloalkyl, G 3 or —(CR a R b ) m -G 3 ; R 4 is hydrogen, G 5 , or —(CR a R b ) m -G 3 ; and G 5 is aryl or heteroaryl; wherein G 5 is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, N(R 2a ) 2 , N(R 2a )C(O)R 2a , OR 2a , C(O)R 2a , C(O)OR 2a , C(O)N(R 2a ) 2 , SO 2 R 2b , and SO 2 N(R 2a ) 2 ; and wherein the G 5 is other than quinolizinone or quinolone.