Patent ID: 8491869

Claim:
A compound of Formula (I): wherein A is a bond, (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, (C 2 -C 4 )alkene, or (C 2 -C 4 )alkyne; Z is: wherein X 1 and X 13 are each independently C, CH, N, O, or S; X 2 -X 4 , X 9 -X 12 and X 14 -X 18 are each independently C, CH or N; R 1 -R 2 are each independently H, halogen, hydroxy, nitro, cyano, amino, alkyl, alkoxy, —(O—CH 2 —CH 2 ) n — (PEG), monoalkylamino, dialkylamino, monoarylamino, diarylamino, NR 10 COOalkyl, NR 10 COOaryl, NR 10 COalkyl, NR 10 CO aryl, COOalkyl, COOaryl, COalkyl, COaryl, aryl, saturated heterocyclyl, wherein the last seventeen groups are unsubstituted or substituted by one or more radicals selected from the group consisting of halogen, alkyl, haloalkyl, cyano, hydroxyl, amino, monoalkylamino, dialkylamino, alkoxy, R 10 , a radiolabel or alkyl substituted with a radiolabel; R 5 -R 9 are each independently H, halogen, hydroxy, nitro, cyano, amino, alkyl, alkoxy, —(O—CH 2 —CH 2 ) n —, monoalkylamino, dialkylamino, monoarylamino, diarylamino, NR 10 COOalkyl, NR 10 COOaryl, NR 10 COalkyl, NR 10 CO aryl, COOalkyl, COOaryl, COalkyl, COaryl, aryl, heterocyclyl, wherein the last seventeen groups are unsubstituted or substituted by one or more radicals selected from the group consisting of halogen, alkyl, haloalkyl, cyano, hydroxyl, amino, monoalkylamino, dialkylamino, alkoxy, R 10 , a radiolabel or alkyl substituted with a radiolabel; R 10 is H, alkyl, alkene, aryl unsubstituted or substituted with halogen, hydroxyl, cyano, nitro, amino, —OSO 2 alkyl, —OSO 2 aryl, —OSi(alkyl) 3 , —OTHP or a radiolabel; n is 1, 2, or 3; m is 1, wherein at least one of R 1 -R 2 and R 5 -R 9 comprises a radiolabel selected from the group consisting of 11 C, 13 N, 15 O, 18 F, 123 I, 124 I, 125 I, 131 I, 76 Br and 77 Br, or a pharmaceutically acceptable salt thereof.