Patent ID: 8623409

Claim:
An oral clonidine liquid suspension composition having a twenty-four hour extended release profile with a single plasma concentration peak following a single oral dose, said dosage unit comprising an aqueous liquid suspension base and a pharmaceutically effective amount of cured, barrier coated, clonidine-cation exchange resin complex-matrix particles, said cured barrier coating comprising polyvinylacetate and a plasticizer and being a cured, water-permeable, high tensile strength, water-insoluble, barrier coating having an elongation factor in the range of about 150% to 400%, wherein said cured barrier coating is over the matrix comprising a hydrophilic or hydrophobic matrix forming polymer and a complex comprising clonidine bound to a cationic exchange resin in a ratio of about 1:120 to about 1:180 clonidine to cation exchange resin, wherein said liquid suspension provides a mean plasma clonidine concentration in human patients of about 0.5 ng/mL at about 6 to about 10 hours following a single clonidine dose of about 0.2 mg.