Patent ID: 7550473

Claim:
A compound of the following formula (I): wherein: R 1 is C 1-8 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-8 alkyl, naphthyl, quinolinyl, aryl-C 1-8 alkyl, or heteroaryl-C 1-8 alkyl, wherein in each of the C 1-8 alkyl groups a methylene group may optionally be replaced by —NHC(O)— or —C(O)NH—, and wherein each of the C 1-8 alkyl groups is optionally substituted by an oxo group or one or more C 1-3 alkyl groups wherein two alkyl substituents on the same carbon atom of a C 1-8 alkyl group may optionally be combined to form a C 2-5 alkylene bridge, and wherein the aryl group is optionally substituted on adjacent carbon atoms by a C 3-6 alkylene bridge group wherein a methylene group is optionally replaced by an oxygen, —S—, —S(O)—, —SO 2 — or —N(R 6 )—; or R 1 has the following structure: wherein x and y are independently 0, 1, 2, 3 or 4, provided that x+y is 2 to 4, z is 0, 1 or 2, and one or two CH 2 groups in the ring may optionally be replaced by —O—, —S—, —S(O)—, —SO 2 — or —N(R 6 ); wherein each R 1 group is optionally substituted by one or more of the following groups: C 1-6 alkyl, C 3-6 cycloalkyl, halogen, nitro, hydroxy, C 1-6 alkyloxy, C 1-6 alkylthio, aryl, arylC 1-6 alkyl, aryloxy, arylthio, aminosulfonyl, or amino optionally substituted by one or two C 1-6 alkyl groups, wherein each aryl group is optionally substituted by one or more C 1-6 alkyl, halogen, nitro, hydroxy or amino optionally substituted by one or two C 1-6 alkyl groups, and wherein in each of the C 1-6 alkyl groups a methylene group may optionally be replaced by —NHC(O)— or —C(O)NH—, and wherein each of the C 1-6 alkyl groups is optionally substituted by one or more halogens; R 2 is selected from the following groups: wherein: n is an integer from 3 to 8; p is an integer from 1 to 3; q is an integer from 0 to 3; R 4 and R 5 are each independently selected from hydrogen, C 1-6 alkyl, arylC 1-6 alkyl, or amidino, wherein each aryl group is optionally substituted by one or more C 1-6 alkyl, halogen, nitro, hydroxy or amino optionally substituted by one or two C 1-6 alkyl groups, and wherein each of the C 1-6 alkyl groups is optionally substituted by one or more halogens, and wherein the amidino is optionally substituted by one to three C 1-6 alkyl; R 6 is hydrogen or C 1-6 alkyl; wherein each R 2 group is optionally substituted by one or more C 1-6 alkyl, C 1-6 alkoxy, CN, — OH, —NH 2 or halogen; R 3 is halogen, cyano, nitro, C 1-6 alkyl, C 1-6 alkyloxycarbonyl or aminocarbonyl; or a tautomer, or pharmaceutically acceptable salt thereof, or a corresponding compound having at least one amine group protected by an amino-protecting group; with the proviso that the following trisubstituted pyrimidine compounds are excluded: 2-(benzylamino)-4-(4-aminomethyl-cyclohexylmethylamino)-5-nitro-pyrimidine; and 2-(2-chlorobenzylamino)-4-(4-aminomethyl-cyclohexylmethylamino)-5-nitro-pyrimidine.