Patent ID: 7544676

Claim:
A compound of formula I: wherein: R 1 is NR y R z ; each R x , R y and R z is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl; or R y and R z , when taken together with the nitrogen atom to which they are attached, form a 3- to 8-membered heterocycloalkyl ring in which 1 or 2 of the heterocycloalkyl ring carbon atoms independently may each be optionally replaced by —O—, —S—, —N(R 9 )—, —N(R 10 )—C(═O)—, or —C(═O)—N(R 10 )—; R 2 and R 3 are each independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroaralkyl, provided that at least one of R 2 and R 3 is other than H; or R 2 and R 3 , when taken together with the nitrogen atom to which they are attached, form a 3- to 8-membered heterocycloalkyl ring in which 1 or 2 of the heterocycloalkyl ring carbon atoms independently may each be optionally replaced by —O—, —S—, —N(R 9 )—, —N(R 10 )—C(═O)—, or —C(═O)—N(R 10 )—; R 4 is H or alkyl; R 5 is: Z is a 1 or 2 heteroatom containing heteroaryl, or a 1 or 2 heteroatom containing heterocycloalkyl, wherein each heteroatom of said heteroaryl or heterocycloalkyl group is independently selected from the group consisting of N, N(R 11 ), O, and S; each R a and R b is independently H or alkyl; R c is H, alkyl, or aryl; R d and R e are each independently H or alkyl, with the proviso that at least two of R c , R d , and R e are other than H; or R d and R e , taken together with the carbon atom to which they are attached, form a carbocyclic or heterocyclic ring; or R c , R d , and R e , taken together with the carbon atom to which they are attached, form a bicycloalkyl, tricycloalkyl, heterobicyclic, or heterotricyclic ring; R 6 and R 8 are each independently H or alkyl; each R 9 is independently H, alkyl, aryl, —C(═O)—R 11 , —C(═O)—OR 11 , —[C(R 11 )(R 11 )] s —C(═O)—OR 11 , —SO 2 R 11 , or —C(═O)N(R 11 )R 11 ; each R 10 is independently H, alkyl, or aryl; each R 11 is independently H or alkyl; r is 0, 1, 2, or 3; and s is 1, 2, 3, or 4; with the provisos that: (1) when R d and R e are each independently H or alkyl, then R c is H or alkyl; (2) when R c is aryl, then R d and R e , taken together with the carbon atom to which they are attached, form a carbocyclic or heterocyclic ring; (3) NR y R z is other than an optionally substituted piperazine ring; and (4) when R 4 is H, R 5 is sec-butyl, and R 6 , R 8 , and one of R 2 and R 3 is H, then the other of R 2 and R 3 is other than; or a pharmaceutically acceptable salt thereof.