Patent ID: 7820704

Claim:
A compound of Formula I, wherein m is 0; A is R 1 is —C 1-5 alkylene-G 1 : R 4 is selected from the group consisting of: -thienyl and —C 1-4 alkylene-thienyl; R 6 and R 7 are independently selected from the group consisting of: a) -hydrogen; b) -halo; c) -alkyl; d) -L-D 1 -H; e) -L-D 1 -alkyl; f) -L-D 1 -aryl; g) -L-D 1 -heteroaryl; h) -L-D 1 -cycloalkyl; i) -L-D 1 -heterocyclyl; j) -L-D 1 -arylene-alkyl; k) -L-D 1 -alkylene-arylene-alkyl; l) -L-D 1 -alkylene-aryl; m) -L-D 1 -arylene-aryl; n) -L-D 2 -(aryl) 2 ; and o) -L-D 2 -(arylene-alkyl) 2 ; wherein at least one of R 6 and R 7 is not hydrogen; W is S; G 1 is —CO 2 H; L is a direct bond, alkylene, alkenylene, alkynylene, or arylene; D 1 is selected from the group consisting of: a direct bond, —CH 2 —, —O—, —N(R 8 )—, —C(O)—, —CON(R 8 )—, —CON(R 9 )SO 2 —, —N(R 9 )C(O)—, —N(R 9 )CON(R 8 )—, —N(R 8 )C(O)O—, —OC(O)N(R 8 )—, —N(R 8 )SO 2 —, —SO 2 N(R 8 )—, —C(O)—O—, —O—C(O)—, —S—, —S(O)—, —S(O 2 )—, or —N(R 8 )SO 2 N(R 9 )—, —N═N—, and —N(R 8 )—N(R 9 )—; D 2 is N, alkylyne, or alkenylyne; R 8 and R 9 are independently selected from the group consisting of: -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, and -alkylene-arylene-alkyl; and wherein the aryl, heteroaryl, heterocyclyl, cycloalkyl, and/or alkyl group(s) in R 1 , R 4 , R 6 , R 7 , R 8 , R 9 , and L may be optionally substituted 1-4 times with a substituent group selected from the group consisting of a) -hydrogen; b) halogen; c) hydroxyl; d) cyano; e) carbamoyl; f) —B-alkyl; g) —B-perhaloalkyl; h) —B-cycloalkyl; i) —B-heterocyclyl; j) —B-aryl; k) —B-heteroaryl; l) —B-alkylene-heteroaryl; m) —B-alkylene-aryl; n) —B-arylene-alkyl; o) —B-perhaloalkyl; p) —B-cycloalkylene-T-R 14 ; q) —B-alkylene-N—R 14 R 15 ; r) —B-cycloalkylene-alkyl; and s) —B-alkylene-cycloalkyl; wherein B and T are independently selected from the group consisting of: direct bond, alkylene, —CH 2 —, —O—, —N(H), —S—, SO 2 —, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —NHSO 2 NH, —O—S(O) 2 —, and —O—C(O)—; wherein R 14 and R 15 are independently selected from the group consisting of: hydrogen, heteroaryl, cycloalkyl, heterocyclyl, aryl, alkyl, -alkylene-aryl, -alkylene-heteroaryl, and alkylene-O-aryl; or R 14 and R 15 may be taken together to form a ring having the formula —(CH 2 ) q -J-(CH 2 ) r — bonded to the nitrogen atom to which R 14 and R 15 are attached wherein q and r are independently equal to 1, 2, 3, or 4; J is a direct bond, —CH 2 —, —O—, —S—, —S(O 2 )—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO 2 —, —SO 2 N(H)—, —C(O)—O—, —O—C(O)—, —NHSO 2 NH—, R 17 and R 18 are independently selected from the group consisting of: hydrogen, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl, -alkyene-heteroaryl, and -alkylene-aryl; or a pharmaceutically acceptable salt, prodrug, or solvate thereof.