Patent ID: 7034025

Claim:
A method of treating a disorder selected from cholera and travel diarrhea in a patient comprising administering to said patient an amount of a compound of the formula wherein R 1 is selected from the group consisting of hydrogen, lower alkyl and lower alkylthio, R 2 and R 3 are individually hydrogen or lower alkyl, R 4 is or ═O, R 5 is selected from the group consisting of a) hydrogen and b) lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocycle and heterocycle lower alkyl, all unsubstituted or substituted with a member selected from the group consisting of lower alkyl, —O—R 10 , —S(O) m —R 10 , —N—C(O)—R 10 , —NH—(SO 2 )—R 11 —COOR 12 and m is an integer from 0 to 2, R 6 and R 7 are individually selected from the group consisting of a) hydrogen, b) unsubstituted and c) lower alkyl, aryl, aryl lower alkyl, heterocycle and heterocycle lower alkyl, unsubstituted or substituted with a member of the group consisting of —OH, halogen, lower alkyl, lower alkoxy, —COOH and or taken together with the carbon atom to which they are attached form aryl or heterocycle, R 8 and R 9 are individually selected from the group consisting of a) hydrogen and b) lower alkyl, aryl lower alkyl, heterocycle and heterocycle lower alkyl, all unsubstituted or substituted with a member of the group consisting of —OH, halogen, lower alkyl, lower alkoxy, —COOH and or taken together with the carbon atoms to which they are attached form aryl or heterocycle, R 10 and R 1 are individually selected from the group consisting of hydrogen, lower alkyl, aryl, aryl lower alkyl, heterocycle and heterocycle lower alkyl, R 13 is unsubstituted lower alkyl or lower alkyl substituted with a member selected from the group consisting of lower alkyl, —O—R 10 , —S(O) m —R 10 and R 14 is hydrogen or lower alkyl, it being understood that A1 can also be a dimmer when two R 1 are hydrogen, and its non-toxic, pharmaceutically acceptable salts, sufficient to treat said disorder.