Patent ID: 7038084

Claim:
A compound represented by the formula: or a pharmaceutically acceptable salt, prodrug, or ester thereof wherein: x represents 0, 1 or 2; t represents either 0 or 1; R 1 represents hydrogen, —CH 2 SO 2 NH 2 , —CO 2 CH 3 , —CONHCH 3 , —CON(CH 3 ) 2 , —CH 2 C(O)NHCH 3 , —CH 2 C(O)N(CH 3 ) 2 , —CONH 2 , —C(CH 3 ) 2 (SH), —C(CH 3 ) 2 (SCH 3 ), —C(CH 3 ) 2 (S[O])CH 3 ), —C(CH 3 ) 2 (S[O] 2 CH 3 ), alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals and amino acid side chains selected from asparagine, S-methyl cysteine and the corresponding sulfoxide and sulfone derivatives thereof, glycine, leucine, isoleucine, allo-isoleucine, tert-leucine, phenylalanine, ornithine, alanine, norleucine, glutamine, valine, threonine, serine, o-alkyl serine, aspartic acid, beta-cyano alanine, and allothreonine side chains; R 3 represents hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical; X′ represents N, O, and C(R 17 ) wherein R 17 represents hydrogen and alkyl radicals; Y and Y′, independently represent O, S and NR15 wherein R15 represents hydrogen and radicals as defined for R 3 ; R 4 represents radicals as defined by R 3 except for hydrogen; R 6 represents hydrogen and alkyl radicals; R 30 , R 31 and R 32 represent radicals as defined for R 1 , or one of R 1 and R 30 together with one of R 31 and R 32 and the carbon atoms to which they are attached form a cycloalkyl radical; or R 30 and R 32 together with the carbon atoms to which they are attached form a three to six-membered cycloalkyl radical; and R 33 and R 34 independently represent hydrogen, radicals as defined for R 3 , or R 33 and R 34 together with X′ represent cycloalkyl, aryl, heterocyclyl and heteroaryl radicals, provided that when X′ is O, R 34 is absent.