Patent ID: 7868035

Claim:
A compound represented by the formula: or a pharmaceutically acceptable salt thereof; wherein J and K are independently C═O, CHOH, CHCl, CHF, or CHOR 1 wherein R 1 is C 1-6 alkyl; D is N or CH; n is 0 or 1; A is —(CH 2 ) 6 —, cis-CH 2 CH═CH—(CH 2 ) 3 —, or —CH 2 C═C—(CH 2 ) 3 —, wherein 1 or 2 carbon atoms may be substituted with S or 0; or A is —(CH2), —Ar—(CH 2 )—, wherein Ar is interarylene or heterointerarylene, the sum of m and o is from 1 to 4, and wherein one CH 2 may be substituted with S or 0; B is CH 2 —CH 2 —CHOR 6 R, CH═CH—CHOR 6 R, or C═C—CHOR 6 R; wherein R 6 is H, methyl or ethyl; and R is alkyl, aryl, heteroaryl, heteroalkyl, arylalkyl, heteroarylalkyl, heteroarylheteroalkyl, or arylheteroalkyl having from 1 to 12 carbon atoms; Y is a biogenic amine having greater than 5 carbon atoms selected from the group consisting of tropicamide, epinephrine, isoprotenenol, dopamine, phentolamine, timolol, salbutanol, salmeterol, trancylpromine, serotonin and thyroxine; and wherein said compound is not an ester of prostaglandin F 2α and timolol.