Patent ID: 7030145

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein B is CH; D is NH; R 1 is selected from the group consisting of H, —CN, C 1-4 alkyl, C 3-7 cycloalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy and N(C 1-4 alkyl) 2 optionally and independently substituted with 1 to 3 substituents selected from the group consisting of —CN, hydroxy, halo, C 1-4 haloalkyl and C 1-4 alkoxy; R 2 is selected from the group consisting of H, halo, —CN, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 1-6 alkoxy, C 1-6 haloalkyl, —NR 4 R 6 , —C 1-6 alkylNR 4 R 6 , —C 1-6 alkylOR 6 , CO 2 R 6 , O 2 CR 6 , COR6, CON4R6, NR4CO2R6, NR4SO2R6, NR4COR6, OCONR4R6 and NR4CONR5R6; optionally and independently substituted with 1 to 3 substituents selected from the group consisting of —CN, hydroxy, halo, C1–4 haloalkyl, C1–4 alkoxy, CO2C1–4 alkyl or phenyl; R 3 is selected from the group consisting of H, halo, —CN, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 1-6 alkoxy, C 1-6 haloalkyl, —NR 4 R 6 , —C 1-6 alkylNR 4 R 6 , —C 1-6 alkylOR 6 , CO 2 R 6 , O 2 CR 6 , COR 6 , CON 4 R 6 , NR 4 CO 2 R 6 , NR 4 SO 2 R 6 , and NR 4 COR 6 ; optionally and independently substituted with 1 to 3 substituents selected from the group consisting of —CN, hydroxy, halo, C 1-4 haloalkyl, C 1-4 alkoxy, CO 2 C 1-4 alkyl, or phenyl; Ar is selected from the group consisting of phenyl, indanyl, and indenyl, independently and optionally substituted with 1 to 4 substituents selected from the group consisting of H, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-4 alkoxy-C 1-4 alkyl, —OR 4 , halo, C 1-4 haloalkyl, —CN, —NO 2 , SH, —S(O) 2 R 5 , —COR 4 , —CO 2 R 4 , —OC(O)R 5 , —N(COR 4 ) 2 , —NR 4 R 7 and —CONR 4 R 7 , —NR 4 COR 5 , NR 4 SO 2 R 5 , NR 4 CONR 5 R 7 , and NR 4 CO 2 R 5 ; R 4 , R 5 and R 7 are independently selected from the group consisting of H, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 3-6 alkyl, C 1-2 alkoxy-C 1-4 alkyl and C 1-4 haloalkyl; and R 6 is selected from the group consisting of H, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-6 alkyl, C 1-2 alkoxy-C 1-2 alkyl, C 1-4 haloalkyl, phenyl and C 1-6 alkyl-phenyl.