Patent ID: 8012482

Claim:
A humanized antibody that binds a TGF-beta1, TGF-beta2 or TGF-beta3 protein, the humanized antibody comprising: a variable heavy (V H ) domain that comprises the non-human hypervariable region residues of SEQ ID NO: 21, SEQ ID NO: 22 and SEQ ID NO: 23 incorporated into a human V H domain, said variable domain further comprising a framework region (FR) comprising the framework residues of SEQ ID NO:6 and comprising one or more FR substitutions in SEQ ID NO:6 at a position selected from the group consisting of 48, 49, 68, and 72; and a variable light (V L ) domain chain that comprises complementarity-determining-region (CDR) residues RASQSVLYSSNQKNYLA (SEQ ID NO:18) or RASQGISSYLA (SEQ ID NO:7); WASTRES (SEQ ID NO:19) or YASSLQS (SEQ ID NO:8); and HQYLSSDT (SEQ ID NO:20).