Patent ID: 7879362

Claim:
An oral pharmaceutical composition for controlled release and prolonged absorption of at least one active principle in the gastrointestinal tract, wherein the composition comprises: a plurality of particles having a diameter of 50 to 1000 microns, wherein the particles comprise at least one active principle and excipients, wherein the particles are individually coated with a coating composition; and wherein said coating composition comprises at least one film-forming polymer which is insoluble in the fluids of the intestinal tract, at least one nitrogenous polymer, and at least one plasticizer; and a continuous external phase of excipients comprising: a polyelectrolytic hydrophilic polymer selected from the group consisting of polyelectrolytic acrylic polymers, polyelectrolytic cellulose polymers, polyelectrolytic polysaccharides polymers, and mixtures thereof, wherein the polyelectrolytic hydrophilic polymer is capable of gelling or crosslinking and is present in a proportion of 60 to 90% by weight on a dry basis with respect to the total mass of the continuous external phase; a neutral hydrophilic polymer selected from the group consisting of hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose (HPC), and mixtures thereof, and wherein the neutral hydophilic polymer is present in a proportion of 5 to 40% by weight on a dry basis with respect to the total mass of the continuous external phase; and a gelling or crosslinking additive having a cation with a valency of two or more present in the proportion of 1 to 5% by weight on a dry basis with respect to the total mass of the continuous external phase; and wherein a mixture of said plurality of particles and of said continuous external phase of excipients spontaneously forms, in the presence of water in a dissolution test, a macroscopic solid gel composite in less than 30 minutes.