Patent ID: 8609818

Claim:
An isolated antibody, or an antigen-binding fragment thereof, that binds to human FN14, comprising: (a) a heavy chain variable region comprising the VHCDR1 amino acid sequence set forth in SEQ ID NO:79, and the VHCDR2 amino acid sequence set forth in SEQ ID NO:92 wherein Xaa at position 4 is Asp or Tyr and the VHCDR3 amino acid sequence set forth in SEQ ID NO:93, wherein Xaa at position 2 is Ala or Gly, Xaa at position 4 is Ser or Thr, and Xaa at position 5 is Ser or Gly; and (b) a light chain variable region comprising the VLCDR1 amino acid sequence set forth in SEQ ID NO:86, and the VLCDR2 amino acid sequence set forth in SEQ ID NO:39 and the VLCDR3 amino acid sequence set forth in SEQ ID NO:94,wherein Xaa at position 3 is Ala or lle.