Patent ID: 7598273

Claim:
A compound of Formula 1 or a single enantiomer, a mixture of the (+)-enantiomer and the (−)-enantiomer, an individual diastereomer, a mixture of diastereomers, or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 4 , R 9 and R 10 are each independently hydrogen or deuterium; R 2 , R 3 , R 6 and R 8 are each independently selected from the group consisting of hydrogen, deuterium, C 1 -C 6 alkyl, and C 1 -C 6 alkyloxy; R 5 is selected from the group consisting of —CH 2 —, —CHD— and —CD 2 —; and R 7 is selected from the group consisting of hydrogen, deuterium, —NO 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkyloxy; if R 1 , R 3 , and R 4 are deuterium, R 2 is —OCH 3 , R 6 is CH 3 , R 7 is OCH 3 , and R 8 is —CH 3 , then at least one of R 5 , R 9 , and R 10 has deuterium enrichment of at least about 1%; if R 1 , R 2 , R 3 , and R 4 are deuterium, is R 6 is —CH 3 , and R 7 is —OCH 2 CF 3 , then at least one of R 8 , R 9 , and R 10 has deuterium enrichment of at least about 1%; if R 2 is —OCHF 2 , R 6 is —OCH 3 , and R 7 is —OCD 3 , then at least one of R 1 , R 3 , R 4 , R 5 , R 8 , R 9 , and R 10 has deuterium enrichment of at least about 1%; provided that said compound of Formula 1 contains at least one deuterium atom; and provided that deuterium enrichment in said compound of Formula 1 is at least about 1%.