Patent ID: 7329760

Claim:
A process for preparing a compound of the formula A-B-C, wherein the formula (I), as hereinafter defined represents the group AH and B-C represents a compound selected from the group consisting of formulae (V)-(VIII) as hereinafter defined, said process comprising: (a) preparing a compound of formula (I) comprising: (i) providing a compound of formula (II), wherein R is a protecting group, (ii) performing halogenation, alkylation and ring-closure reactions upon a compound of formula (II) under suitable conditions to provide a racemic compound of formula (III), (iii) isolating the (−) isomer of the racemic compound of formula (III), and (iv) removing said R protecting groups from the isolated (−) isomer of the racemic compound of formula (III) under suitable conditions to produce a compound of formula (I), and (b) linking, via an amide bond, group A, with one compound selected from the group consisting of formulae (V)-(VIII), or linking, via an amide bond, group A, with B of B-C, prior to linking the group B to the group C: wherein R 1 to R 6 may be the same or different and are selected from the group consisting of hydrogen, C 1 -C 3 linear alkyl, methoxy, hydroxyl, primary amino, secondary amino, tertiary amino, and amido, and wherein R″ is an amine or substituted or unsubstituted C 1 -C 20 alkyl amine.