Patent ID: 8461123

Claim:
A pharmaceutical composition comprising an isolated or synthetic dinucleotide analogue, or its salt or ester, comprising one 5-aza-cytosine as a base residue in the sequence of the dinucleotide analogue, wherein the dinucleotide is linked with a phospholinker wherein the number of phosphorus atoms in the phospholinker is one, and wherein the dinucleotide analogue has a general formula of: a. Z-L-G, or G-L-Z, wherein Z is 5-aza-cytosine; G is guanine; and L is a phospholinker covalently linking Z and G, wherein the number of phosphorus atoms in the phospholinker is one; or b. 5′-DpG-3′ or 5′GpD-3′, wherein D is decitabine; p is a phospholinker wherein the number of phosphorus atoms in the phospholinker is one; and G is deoxyguanosine, and a pharmaceutically-acceptable carrier, wherein the pharmaceutically-acceptable carrier is a solution or an emulsion.