Patent ID: 7402704

Claim:
A compound having the formula: or pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs thereof, wherein: R 1 is a member selected from the group consisting of —OH, halogen and (C 1 -C 8 )haloalkyl; R 2 and R 3 are members independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl and (C 3 -C 8 )cycloalkyl, wherein no more than two of R 1 , R 2 and R 3 are halogen; R 4 , R 5 , R 6 , R 7 and R 8 are each members independently selected from the group consisting of H, halogen, —CN, —NO 2 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkoxy, aryl, aryl(C 1 -C 6 )alkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR″, —OR″, —OC(O)R′, —C(O)N(R′) 2 , —S(O)R″, —SO 2 R″, —SO 2 N(R′) 2 , —N(R′) 2 , —NR′C(O)R′, —X—C(O)R′, —X—C(O)OR′, —X—NR′C(O)OR″, —X—OR″, —X—OC(O)R′, —X—C(O)N(R′) 2 , —X—S(O)R″, —X—SO 2 R″, —X—SO 2 N(R′) 2 , —X—N(R′) 2 and —X—NR′C(O)R′; and optionally two of R 4 , R 5 , R 6 , R 7 and R 8 when attached to adjacent carbon atoms are combined to form a fused 5-, 6- or 7-membered aryl or cycloalkyl ring, and any fused ring portion, cycloalkyl portion, or aryl is optionally substituted with from one to four members selected from the group consisting of H, halogen, —CN, —NO 2 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR″, —OR′, —SR′, —OC(O)R′, —C(O)N(R′) 2 , —S(O)R″, —SO 2 R″, —SO 2 N(R′) 2 , —N(R′) 2 and —NR′C(O)R′; wherein X is a branched or straight chain (C 1 -C 8 )alkylene group; each occurrence of R′ is independently H or an unsubstituted member selected from the group consisting of (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkyl; each occurrence of R″ is independently an unsubstituted member selected from the group consisting of (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl, (C 1 -C 8 )haloalkyl, (C 2 -C 8 )hydroxyalkyl, (C 3 -C 8 )cycloalkyl, aryl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkyl; and R 9 is H or halogen with the proviso that the compound is other than 2-{4-[4-(1-Hydroxy-1-methyl-ethyl)-benzenesulfonyl]-phenyl}-propan-2-ol or 1-(1-chloro-1-methylethyl)-4-(phenylsulfonyl)benzene.