Patent ID: 7732451

Claim:
A method of decreasing food intake and/or decreasing body weight in a mammal without eliciting a sexual response, comprising administration to a mammal in need thereof of a therapeutically effective amount of a pharmaceutical composition comprising a melanocortin receptor compound of the formula: wherein: L is a conformationally restricted ring system consisting of a single non-aromatic heterocyclic ring system, with the single ring comprising 6 atoms; R 1 is a linker unit comprising from one to six backbone atoms selected from the group consisting of carbon (C), oxygen (O) and nitrogen (N) and an unsubstituted naphthalene group; R 2 is —(CH 2 ) 4 NH 2 , —(CH 2 ) 3 NHC(NH 2 )═NH, —(CH 2 ) 3 NHCOCH 3 , —(CH 2 ) 3 NHCOOCH 3 , —(CH 2 ) 2 NHC(NH 2 )═NH, —(CH 2 ) 2 NHCONH 2 , —(CH 2 ) 4 NHCOH, —(CH 2 ) 4 NHCOCH 3 , —(CH 2 ) 3 NHCONHCH 3 , —(CH 2 ) 3 NHSO 2 NH 2 , —(CH 2 ) 3 NHSO 2 CH 3, —(CH 2 ) 3 NH 2 , —(CH 2 ) 3 NH(C═NH)NHMe, —(CH 2 ) 3 NH(C═NH)NHEt, —(CH 2 ) 3 NH(C═NH)NHPr, —(CH 2 ) 3 NH(C═NH)NHPr-i, —(CH 2 ) 3 NH(C═NH)NH 2 , —(CH 2 ) 4 NHCONH 2 , —(CH 2 ) 4 NH(C═NH)NH 2 , R 3 comprises a linker unit and at least one carbocyclic aromatic ring; and R x comprises from zero to three additional pendant groups; or an enantiomer, stereoisomer or diastereoisomer thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.