Patent ID: 7718658

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or derivative thereof, wherein: R 1 and R 2 , taken together with the nitrogen atom, form a substituted ring (C): wherein, in ring (C): G 3 is —N; each of m 3 and n 3 is independently 0-3, provided that m 3 +n 3 is 2-6; p 3 is 0-2; z 3 is 0-4; each R XX is hydrogen, C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein R XX is optionally substituted with w 3 independent occurrences of —R 13 , wherein w 3 is 0-3; provided that both R XX are not simultaneously hydrogen; R YY is hydrogen, —COR′, —CO 2 R′, —CON(R′) 2 , —SOR′, —SO 2 R′, —SO 2 N(R′) 2 , —COCOR′, —COCH 2 COR′, —P(O)(OR′) 2 , —P(O) 2 OR′, or —PO(R′); x and y, each, is independently 0-4; each occurrence of R 13 , R 3 , R 4 , and R 5 is independently Q-R X ; wherein Q is a bond or is a C 1 -C 6 alkylidene chain wherein up to two non-adjacent methylene units of Q are optionally and independently replaced by —NR—, —S—, —O—, —CS—, —CO 2 —, —OCO—, —CO—, —COCO—, —CONR—, —NRCO—, —NRCO 2 —, —SO 2 NR—, —NRSO 2 —, —CONRNR—, —NRCONR—, —OCONR—, —NRNR—, —NRSO 2 NR—, —SO—, —SO 2 —, —PO—, —PO 2 —, —OP(O)(OR)—, or —POR—; and each occurrence of R X is independently selected from —R′, halogen, ═O, ═NR′, —NO 2 , —CN, —OR′, —SR′, —N(R′) 2 , —NR′COR′, —NR′CON(R′) 2 , —NR′CO 2 R′, —COR′, —CO 2 R′, —OCOR′, —CON(R′) 2 , —OCON(R′) 2 , —SOR′, —SO 2 R′, —SO 2 N(R′) 2 , —NR′SO 2 R′, —NR′SO 2 N(R′) 2 , —COCOR′, —COCH 2 COR′, —OP(O)(OR′) 2 , —P(O)(OR′) 2 , —OP(O) 2 OR′, —P(O) 2 OR′, —PO(R′) 2 , or —OPO(R′) 2 ; and each occurrence of R is independently hydrogen or C 1-6 aliphatic group having up to three substituents; and each occurrence of R′ is independently hydrogen or C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein R′ has up to four substituents; or R and R′, two occurrences of R, or two occurrences of R′, are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur.