Patent ID: 7476650

Claim:
A method for treating a proliferative disease selected from psoriasis and restenosis in a subject comprising administering to said subject having psoriasis or restenosis a compound of formula I: X is O; R 1 , R 2 , R 3 , and R 4 are, independently, hydrogen or a branched or unbranched: C1-6 alkyl group, C 1-6 hydroxy alkyl group, C 1-6 alkoxy, or aryl or aryl-substituted C 1-6 alkyl group, any of which can be substituted with amide linkages, amines, carboxylic acids and salts thereof, carboxyl esters, thiols, or thioethers; and R 5 is a chain of amino acids, hydrogen, an acetyl group, C 1-6 alkanoyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a protecting group; with the proviso that, simultaneously, R 1 is not iso-butyl, R 2 is not 1-hydroxy ethyl, R 3 is not sec-butyl, R 4 is not sec-butyl, and R 5 is not an acetyl group.