Patent ID: 8222416

Claim:
A compound of formula (I): wherein: R1 is -phenyl, unsubstituted or mono- or bi-substituted independently with halogen, -cyano, -lower alkyl, -alkoxy, —SO 2 CH 3 , —CF 3 , —C(CH 3 ) 2 OH, —CH(CH 3 )OH, —C(CH 3 )(C(CH 3 ) 2 )OH, —SO 2 (CH 2 ) 2 OH, —NH(SO 2 CH 3 ), —C(O)CH 3 , —C(CH 2 CH 3 ) 2 OH, —N(CH 3 ) 2 , —SO 2 CH(CH 3 ) 2 , —SO 2 (CH 2 ) 2 OCH 2 CH 3 , —SO 2 (CH 2 ) 2 N(CH 3 ) 2 , pyrazole or —SO 2 (CH 2 ) 2 -morpholine, -heteroaryl, unsubstituted or substituted with lower alkyl, alkoxy or —SO 2 CH 3 , or -2,3-dihydrobenzo[1,4]dioxin-6-yl; R2 is -lower alkyl, -heterocycloalkyl, or -cycloalkyl, unsubstituted or substituted with (═O); R3 is -hydrogen, -halogen, -an acyl group, -cyano, -lower alkyl, unsubstituted or mono-, bi- or tri-substituted independently with hydroxy, alkoxy, halogen, lower alkyl, cyano, (═O), or —N(CH 3 ) 2 , —OCH 3 , —OCH 2 C(O)N(CH 3 ) 2 , —O(CH 2 ) 2 OCH 3 , —O(CH 2 ) 2 N(CH 3 ) 2 , —OCH(CH 3 ) 2 , —OC(CH 3 ) 2 CH 2 OH, —OCH 2 CH 2 OH, —OC(CH 3 ) 2 C(O)OCH 2 CH 3 , —OC(CH 3 ) 2 C(O)OH, —CH 2 OC(O)CH 2 N(CH 3 ) 2 , —NHC(O)CH 2 N(CH 3 ) 2 , or —SO 2 -lower alkyl; the bond between C 1 and C 2 is a single or double bond; X1 is -hydrogen, -hydroxy, -alkoxy, or -absent if the bond between C 1 and C 2 is a double bond; and X2 is -hydrogen, or -absent if the bond between C 1 and C 2 is a double bond, or a pharmaceutically acceptable salt thereof.