Patent ID: 8735553

Claim:
An antibody antigen binding domain which specifically binds human PD-1, and comprises complementarity determining region (CDR) 1, CDR2 and CDR3, in a combination selected from (a)-(r) as follows, wherein the antibody (Ab), heavy chain (HC) or light chain (LC) and CDR nomenclature system (Kabat, IMGT or composite) from which the CDR combinations derive are shown in the first column, and residues in bold text are Kabat system, and residues underlined are IMGT system: Ab, Chain System CDR1 mu317 GFSLT SYG VH HC (a) Kabat SEQ ID NO: 11, res. 6-10 (b) IMGT SEQ ID NO: 11, res. 1-8 (c) Comp. SEQ ID NO: 11 mu317 KAS QSVSND VA LC (d) Kabat SEQ ID NO: 14- (e) IMGT SEQ ID NO: 14, res. 4-9 (f) Comp. SEQ ID NO: 14 317-4B6 GFSLT SYG VH HC (g) Kabat SEQ ID NO: 11, res. 6-10 (h) IMGT SEQ ID NO: 11, res. 1-8 (i) Comp. SEQ ID NO: 11 317-4B6 KSS ESVSND VA LC (j) Kabat SEQ ID NO: 34 (k) IMGT SEQ ID NO: 34, res. 4-9 (l) Comp. SEQ ID NO: 34 317-1H GFSLT SYG VH HC (m) Kabat SEQ ID NO: 11, res. 6-10 (n) IMGT SEQ ID NO: 11, res. 1-8 (o) Comp. SEQ ID NO: 11 317-4B2 GFSLT SYG VH HC (p) Kabat SEQ ID NO: 11, res. 6-10 (q) IMGT SEQ ID NO: 11, res. 1-8 (r) Comp. SEQ ID NO: 11 Ab, Chain System CDR2 mu317 V IWAGGST NYNSALMS HC (a) Kabat SEQ ID NO: 12 (b) IMGT SEQ ID NO: 12, res. 2-8 (c) Comp. SEQ ID NO: 12 mu317 YAF HRFT LC (d) Kabat SEQ ID NO: 15 (e) IMGT SEQ ID NO: 15, res. 1-3 (f) Comp. SEQ ID NO: 15 317-4B6 V IYADGST NYNPSLKS HC (g) Kabat SEQ ID NO: 32 (h) IMGT SEQ ID NO: 32, res.2-8 (i) Comp. SEQ ID NO: 32 317-4B6 YAF HRFT LC (j) Kabat SEQ ID NO: 15 (k) IMGT SEQ ID NO: 15, res.1-3 (l) Comp. SEQ ID NO: 15 317-1H V IWAGGST NYNPSLKS HC (m) Kabat SEQ ID NO: 59 (n) IMGT SEQ ID NO: 59, res. 2-8 (o) Comp. SEQ ID NO: 59 317-4B2 V IYAGGST NYNPSLKS HC (p) Kabat SEQ ID NO: 60 (q) IMGT SEQ ID NO: 60, res.2-8 (r) Comp. SEQ ID NO: 60 Ab, Chain System CDR3 mu317 AR AYGNYWYIDV HC (a) Kabat SEQ ID NO: 13, res. 3-12 (b) IMGT SEQ ID NO: 13 (c) Comp. SEQ ID NO: 13 mu317 HQAYSSPYT LC (d) Kabat SEQ ID NO: 16 (e) IMGT SEQ ID NO: 16 (f) Comp. SEQ ID NO: 16 317-4B6 AR AYGNYWYIDV HC (g) Kabat SEQ ID NO: 13, res. 3-12 (h) IMGT SEQ ID NO: 13 (i) Comp. SEQ ID NO: 13 317-4B6 HQAYSSPYT LC (j) Kabat SEQ ID NO: 16 (k) IMGT SEQ ID NO: 16 (l) Comp. SEQ ID NO: 16 317-1H AR AYGNYWYIDV HC (m) Kabat SEQ ID NO: 13, res. 3-12 (n) IMGT SEQ ID NO: 13 (o) Comp. SEQ ID NO: 13 317-4B2 AR AYGNYWYIDV HC (p) Kabat SEQ ID NO: 13, res. 3-12 (q) IMGT SEQ ID NO: 13 (r) Comp. SEQ ID NO: 13.