Patent ID: 8420664

Claim:
A method of treating rheumatoid arthritis in a subject, comprising: administering to the subject an amount of an A 3 adenosine receptor (A 3 AR) allosteric enhancer, the amount being effective to enhance A 3 AR activity, the A 3 AR allosteric enhancer having the following general formula (I): wherein: R 1 represents an aryl or alkaryl being optionally substituted at the aromatic ring once or more with a substituent selected from C 1 -C 10 alkyl, halo, C 1 -C 10 alkanol, hydroxyl, C 1 -C 10 acyl, C 1 -C 10 alkoxyl, C 1 -C 10 -alkoxycarbony, C 1 -C 10 alkoxylalkyl, C 1 -C 10 thioalkoxy; C 1 -C 10 alkylether, amino, hydrazido, C 1 -C 10 alkylamino, pyridylthio, C 2 -C 10 alkenyl; C 2 -C 10 alkynyl, cyano, haloformyl, thio, and C 1 -C 10 alkylthio, acetoamido and sulfonic acid; or said substituents can form together a cycloalkyl or cycloalkenyl fused to said aryl, the cycloalkyl or cycloalkenyl optionally comprising one or more heteroatoms; provided that said aryl is not an unsubstituted phenyl group; R 2 represents hydrogen or a substituent selected from C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 4 -C 10 cycloalkyl, C 4 -C 10 cycloalkenyl, C 4 -C 10 heterocycloalkyl, C 4 -C 10 heterocycloalkenyl, five to seven membered heterocyclic aromatic ring, C 5 -C 15 fused cycloalkyl, bicyclic aromatic or heteroaromatic ring, C 1 -C 10 alkylether, amino, hydrazido, C 1 -C 10 alkylamino, C 1 -C 10 alkoxy, C 1 -C 10 -alkoxycarbony, C 1 -C 10 alkanol, C 1 -C 10 acyl, C 1 -C 10 thioalkoxy, pyridylthio, thio, C 1 -C 10 alkylthio, acetoamido and sulfonic acid; each of said substituents being optionally substituted by at least one group selected from C 1 -C 10 alkyl, halo, C 1 -C 10 alkanol, hydroxyl, C 1 -C 10 acyl, C 1 -C 10 alkoxyl; C 1 -C 10 -alkoxycarbony, C 1 -C 10 alkoxylalkyl, C 1 -C 10 thioalkoxy; C 1 -C 10 alkylether, amino, hydrazido, C 1 -C 10 alkylamino, pyridylthio, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, cyano, haloformyl, isoindole-1,3-dione, thio, C 1 -C 10 alkylthio, aryl, alkaryl, acetoamido and sulfonic acid; and pharmaceutically acceptable salts thereof.