Patent ID: 8394953

Claim:
A compound represented by the formula: in which R 1 is H, COOH, amino, mono- or di(C 1 -C 6 alkyl)amino, halogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, aryl, C 1 -C 8 alkoxy, nitro, or cyano; or R 1 is a radionuclide or a moiety containing, or capable of complexing with, a radionuclide; R 2 is, independently for each occurrence, H, hydroxy, COOH, amino, mono- or di(C 1 -C 6 alkyl)amino, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, aryl, halogen, C 1 -C 8 alkoxy, nitro, cyano, or a radionuclide or a moiety containing, or capable of complexing with, a radionuclide; R 3 , R 4 , R 6 and R 7 are each independently a direct bond or a group which can be cleaved by an enzyme; R 5 and R 8 are each independently a group which can be cleaved by an enzyme selected from the group consisting of prostate specific antigen, matrix metalloproteinases, guanidinobenzoatase, prostate specific membrane antigen, alkaline phosphatase, prostatic acid phosphatase, and human sulfatase-1; and Y is, independently for each occurrence, O, S or NH; provided that at least one occurrence of R 1 or R 2 is a radionuclide or a moiety containing, or capable of complexing with, a radionuclide; or a pharmaceutically acceptable salt thereof.