Patent ID: 7569600

Claim:
A thiophene compound according to formula IB: wherein: R 1 is optionally substituted C 3-12 cycloalkyl, optionally substituted C 4-12 cycloalkenyl, optionally substituted —C(O)—C 3-12 cycloalkyl, optionally substituted —C(O)—C 4-12 cycloalkenyl, optionally substituted 5 to 12 member spiroheterocycloalkyl, or optionally substituted 8 to 12 member spiroheterocycloalkenyl, wherein when R 1 is optionally substituted 5 to 12 member spiroheterocycloalkyl the cycloalkyl moiety is directly attached to the 5-position of the thiophene ring, and when R 1 is optionally substituted 8 to 12 member spiroheterocycloalkenyl the cycloalkenyl moiety is directly attached to the 5-position of the thiophene ring; R 2 and R 3 are each independently H, optionally substituted C 1-12 alkyl, optionally substituted C 2-12 alkenyl, optionally substituted C 2-12 alkynyl, optionally substituted C 6-14 aryl, optionally substituted C 7-16 aralkyl, optionally substituted 5-12 member heteroaryl, optionally substituted 6-18 member heteroaralkyl, optionally substituted 3-12 member heterocycle, or optionally substituted 4-18 member heterocycle-alkyl; Y is COOR 9 , COCOOR 9 , P(O)OR a OR b , S(O)OR 9 , S(O) 2 OR 9 , tetrazole, CON(R 9 )CH(R 9 )COOR 9 , CONR 10 R 11 , CON(R 9 )—SO 2 —R 9 , CONR 9 OH, or halogen; R 9 , R 10 and R 11 are each independently H, optionally substituted C 1-12 alkyl, optionally substituted C 2-12 alkenyl, optionally substituted C 2-12 alkynyl, optionally substituted C 6-14 aryl, optionally substituted C 7-16 aralkyl, optionally substituted 5-12 member heteroaryl, optionally substituted 6-18 member heteroaralkyl, optionally substituted 3-12 member heterocycle, or optionally substituted 4-18 member heterocycle-alkyl, or R 10 and R 11 are taken together with the nitrogen atom to form an optionally substituted 3 to 10 member heterocycle or an optionally substituted 5-12 member heteroaryl; and R a and R b are each independently H, optionally substituted C 1-12 alkyl, optionally substituted C 2-12 alkenyl, optionally substituted C 2-12 alkynyl, optionally substituted C 6-14 aryl, optionally substituted C 7-16 aralkyl, optionally substituted 5-12 member heteroaryl, optionally substituted 6-18 member heteroaralkyl, optionally substituted 3-12 member heterocycle, or optionally substituted 4-18 member heterocycle-alkyl, or R a and R b are taken together with the oxygen atoms to form an optionally substituted 5 to 10 member heterocycle, or an optionally substituted 5-12 member heteroaryl; or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof.