Patent ID: 7411001

Claim:
A compound of formula or a pharmaceutically acceptable salt, wherein R 1 is hydrogen, halogen, or nitro; R 2 is hydrogen or fluorine; R 3 is hydrogen or fluorine; R 4 is hydrogen, iodine, bromine, chlorine, or fluorine; R 5 is hydrogen, halogen, hydroxy, C 1-8 alkyl, C 1-8 alkoxy, trifluoromethyl, or cyano; n is 1 to 5; R 6 , R 7 , R 8 , R 9 , and R 10 are independently hydrogen, C 1-8 alkyl, C 3-8 cycloalkyl, C 1-8 alkoxy, perhalo(C 1-3 )alkyl, hydroxy(C 1-8 )alkyl, (C 1-5 )alkoxy(C 1-5 )alkyl, [(C 1-4 )alkyl] 2 aminomethyl, or aryloxy(C 1-5 )alkyl, wherein R 7 and R 8 are independently selected for n>1; Ra and Rb are independently hydrogen or C 1-4 alkyl; W is O or NRa; R 11 is hydrogen, C 1-8 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, hydroxy(C 1-8 )alkyl, (C 1-5 )alkoxy(C 1-5 )alkyl, phenyl, (C 1-8 )alkylcarbonyl, (phenyl)carbonyl, (phenyl)(C 1-3 alkyl)carbonyl, or trifluoro(C 1-6 )alkyl; wherein the above alkyl, alkoxy, cycloalkyl, and phenyl groups can be optionally substituted with between 1 and 5 substituents independently selected from the group consisting of hydroxy, amino, monoalkylamino, dialkylamino, halogen, cyano, (C 1-3 )alkoxy, COOR, OCORa, CONRaRb, NRaCORb, SO, SO 2 , SO 4 , and SO 2 NRaRb; provided that when R 11 is phenyl and n is 1, W cannot be O; further provided that the compound is not 5-Bromo-N-(2-diethylamino-ethoxy)-3,4-difluoro-(4-iodo-2-methyl-phenylamino)-benzamide; 5-Bromo-N-(2-dimethylamino-propoxy)-3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-benzamide; or 5-Bromo-2-(2-chloro-4-iodo-phenylamino)-N-(2-dimethylamino-ethoxy)-3,4-difluoro-benzamide.