Patent ID: 7556824

Claim:
A transdermal patch comprising a therapeutically effective amount of a hydralazine compound of formula I and at least one of isosorbide dinitrate and isosorbide mononitrate, wherein the isosorbide dinitrate is present in an amount to deliver about 20 milligrams per day to about 200 milligrams per day and/or the isosorbide mononitrate is present in an amount to deliver about 10 milligrams per day to about 120 milligrams per day; wherein the hydralazine compound of formula (I) is: wherein a, b and c are independently a single or double bond; R 1 and R 2 are each independently a hydrogen, an alkyl, an ester or a heterocyclic ring; R 3 and R 4 are each independently a lone pair of electrons or a hydrogen; with the proviso that at least one of R 1 , R 2 , R 3 and R 4 is not a hydrogen.