Patent ID: 8017809

Claim:
A bisboron compound having activity to control the intracellular calcium concentration represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R 1 and R 2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R 3 represents a hydrogen atom; —(CH 2 ) 2 —NR 4 R 5 , wherein R 4 and R 5 independently represent a hydrogen atom, or C1-C4 alkyl substituted or unsubstituted with amino, mono- or di-C1-C4 alkylamino or phenyl group, or R 4 and R 5 are taken together with the nitrogen atom to which they are bonded to form a 5- or 6-membered cyclic ring; —CO—(CH 2 ) m —NR 4 R 5 , wherein m represents an integer of 1 to 4, and R 4 and R 5 are as defined above; —COCH(NH 2 )R 6 , wherein R 6 represents an amino acid residue or —(CH 2 ) n NH 2 , wherein n represents an integer of 1 to 3; —CHR 7 R 8 , wherein R 7 and R 8 independently represent C1-C4 alkyl substituted or unsubstituted with amino, mono- or di-(amino group-substituted or unsubstituted C1-C4 alkyl)amino or phenyl group, pyridyl, or phenyl substituted with C1-C3 alkoxy group; —CH 2 CH(NH 2 )—R 9 , wherein R 9 represents phenyl, or C1-C4 alkyl substituted with phenyl group; quinolyl or isoquinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from CH 2 OCH 2 , and CH 2 OCH 2 CH 2 , or a salt thereof, provided that bis[2-(hydroxyphenylboryl)benzyl]ether, 1,4-bis(4-(hydroxyphenylboryl)phenoxy)butane, bis[4-(hydroxyphenylboryl)benzyl]ether, bis[2-[(2-aminoethoxy)phenylboryl]benzyl]ether, bis[4-((2-aminoethoxy)phenylboryl)benzyl]ether, [4-[(2-aminoethoxy)phenylboryl]benzyl][2-[4-[(2-aminoethoxy)phenylboryl]phenyl]ethyl]ether, [2-[(2-aminoethoxy)phenylboryl]benzyl][2-[4-[(2-aminoethoxy)phenylboryl]phenyl]ethyl]ether and salts thereof are excluded.