Patent ID: 8822435

Claim:
A method of treating osteoporosis, rheumatoid arthritis, osteoarthritis, Paget's disease, or alveolar bone loss comprising administering an effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof to a patient in need of such treatment, wherein R 1 , R 2 , R 3 , R 4 and R 5 are each independently a) hydrogen; b) halogen, —CN, —CF 3 , or —NO 2 ; c) C 1 -C 8 alkyl or C 1 -C 8 haloalkyl; d) C 2 -C 8 alkenyl or C 2 -C 8 haloalkenyl; e) C 2 -C 8 alkynyl or C 2 -C 8 haloalkynyl; f) optionally substituted aryl or optionally substituted heteroaryl; g) —C(O)R 6 ; h) —C(O)OR 6 , or —CO 2 R 6 ; i) —OR 6 , —O-L-OC(O)R 6 , or —O-L-OC(O)OR 6 ; j) —OC(O)R 6 , or —OC(O)-L-OC(O)R 6 ; k) —OC(O)OR 6 , —OC(O)O-L-C(O)R 7 , —OC(O)O-L-C(O)OR 7 , or -L-OC(O)R 6 ; l) —C(O)NR 6 R 7 , or —CNR 6 R 7 ; m) —OC(O)NR 6 R 7 , —OC(O)N(R 6 )-L-OC(O)R 7 , —OC(O)O-L-(R 6 )-L-C(O)R 7 , —OC(O)—C(R 6 )(R 7 )-L-OC(O)R 8 , —OC(O)N(-L-OC(O)R 7 )(-L-OC(O)R 8 ); n) —SR 6 , or —NR 6 R 7 ; o) —NR 6 C(O)R 7 ; p) —NR 6 C(O)OR 7 ; q) —NR 6 C(O)NR 7 ; r) —OSO 2 R 6 ; s) —SO 2 OR 6 ; t) —SO 2 R 6 ; u) —NR 6 SO 2 R 7 ; v) —SO 2 NR 6 R 7 ; bb) R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , or R 4 and R 5 taken together form an optionally substituted 4- to 8-membered carbocyclic or heterocyclic ring, wherein the ring is saturated, unsaturated or aromatic; wherein m and n are each independently an integer from 0 to 2; Y is —CH 2 —, —O—, —NR 7 —, or —S—; p is an integer from 1 to 3; R 14 is hydrogen, halogen, C 1 -C 8 alkyl, or C 1 -C 8 alkoxyl; Z is or each R 6 is independently hydrogen, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 haloalkenyl, C 2 -C 8 alkynyl, C 2 -C 8 haloalkynyl, an optionally substituted 4-8 membered saturated carbocyclic or heterocyclic ring, optionally substituted aryl, optionally substituted heteroaryl, -L-optionally substituted aryl or -L-optionally substituted heteroaryl; R 7 and R 8 are each independently hydrogen or C 1 -C 8 alkyl; and L is C 1 -C 8 alkyl; or R 6 and R 7 taken together form an optionally substituted 4- to 8-membered carbocyclic or heterocyclic ring, wherein the ring is saturated, unsaturated or aromatic.