Patent ID: 8557525

Claim:
A method for determining risk of tumor metastasis in a human having breast cancer, comprising: (a) detecting the expression levels of 14 genes comprising CENPA, PKMYT1, MELK, MYBL2, BUB1, RACGAP1, TK1, UBE2S, DC13, RFC4, PRR11, DIAPH3, ORC6L and CCNB1 in a breast tumor sample from said human, and determining a metastasis score (MS u ) based on the expression levels of said 14 genes; (b) detecting the expression level of progesterone receptor (PR) in said breast tumor sample; and (c) determining a composite metastasis score (cMS u ) that indicates risk of tumor metastasis, wherein said cMS u is calculated from said MS u and said expression level of PR as follows: cMS u =β MS *MS u +β PR *PR wherein β MS is a value between 0.0006 and 0.0667, and wherein β PR is a value between −0.3614 and −0.0497.