Patent ID: 7825247

Claim:
Process for the preparation of a compound of formula I wherein R 3 is (4-methyl-piperazinyl)-methyl and R 1 , R 2 , R 4 and R 5 are independently hydrogen, cyano; lower alkyl; hydroxy- or amino-substituted lower alkyl; trifluoromethyl; hydroxy, etherified or esterified hydroxy; lower alkoxy; lower alkanoyloxy; amino, alkylated or acylated amino; mono- or di-lower alkylamino; lower alkanoylamino; benzoylamino; carboxy or esterified carboxy; lower alkoxycarbonyl and halogen; R 6 is halogen, NH 2 , NO 2 , NHC(O)CF 3 , NHC(O)CH 3 , or NHC(NH)NH 2 , R 7 is methyl and R 8 is hydrogen; or a salt or crystal form thereof, wherein a compound of formula II is reacted with an amine of formula III A) wherein R 9 =methyl, ethyl or aryl: in the presence of 1) a Lewis acid selected from Al(lower alkyl) 3 , AlCl 3 , EtAlCl 2 , MeAlCl 2 , Me 2 AlCl, Et 2 AlCl or the corresponding sesquichlorides, 2) an organic solvent, and optionally 3) a base, and the resulting product is hydrolyzed; or B) wherein R 9 =hydrogen: in the presence of 1) thionylchloride, 2) an organic solvent, and optionally 3) a base.