Patent ID: 8003664

Claim:
A method of treating a disorder of reduced motility of the gastrointestinal tract in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I-a): wherein: R 1 is hydrogen, halo or C 1-4 alkyl; R 2 is isopropyl or C 4-5 cycloalkyl; R 3 is hydroxy, C 1-3 alkoxy, or OC(O)NR a R b ; W is selected from (a) Y, wherein Y is selected from —N(R 8a )C(O)R 9 , —N(R 8a )S(O) 2 R 10 , —N(R 8a )C(O)OR 12 , —N(R 8a )C(O)NR 13 R 14 , and —N(R 8a )S(O) 2 NR 13 R 14 ; and (b) a moiety of formula (b): wherein X is selected from —N(R 8 )C(O)R 9 , —N(R 8 )S(O) 2 R 10 , —S(R 11 )O 2 , —N(R 8 )C(O)OR 12 , —N(R 8 )C(O)NR 13 R 14 , —N(R 8 )S(O) 2 NR 13 R 14 , —C(O)NR 13 R 14 , —OC(O)NR 13 R 14 , —C(O)OR 12 , —OR 15 , —NR 8 R 16 , cyano, —SR 15 , CF 3 , pyridinyl, pyrrolyl, 1,1-dioxoisothiazolidinyl, imidazolyl, and pyrrolidinyl, wherein pyrrolidinyl is optionally substituted with oxo; R 5 is hydrogen, C 1-3 alkyl, or C 1-3 alkyl substituted at the terminal position with hydroxy; R 6 and R 7 at each occurrence are independently hydrogen, hydroxy, halo or cyano; R 8 and R 8a are hydrogen or C 1-3 alkyl; or R 5 and R 8 or R 5 and R 6 together form a C 2-5 alkylene; or R 3 and R 5 or R 3 and R 8a taken together are —OCH 2 CH 2 —; R 9 is hydrogen, tetrahydrofuranyl, pyridinyl, or C 1-3 alkyl; R 10 is C 1-3 alkyl, wherein C 1-3 alkyl is optionally substituted with —S(O) 2 C 1-3 alkyl, or with from 1 to 3 halo; R 11 is —NR a R b , or C 1-3 alkyl, where C 1-3 alkyl is optionally substituted with from 1 to 3 halo; or R 5 and R 11 or R 6 and R 11 taken together form C 2-5 alkylenyl; R 12 is C 1-3 alkyl; R 13 , R 14 , and R 15 are independently hydrogen or C 1-3 alkyl; R 16 is —CH 2 —C(O)NR a R b , —CH 2 —C(O)-morpholinyl, —CH 2 -pyridinyl, —CH 2 -pyrimidinyl, or —CH 2 -tetrahydrofuranyl; R 18 is —C(O)OCH 3 , —S(O) 2 CH 3 , or —C(O)CH 3 ; R a and R b are independently hydrogen or C 1-3 alkyl; a is 0 or 1; and n is an integer of 1, 2, or 3; provided that when n is 1, X is —SR 15 , or X forms a carbon-carbon bond with the carbon atom bearing the substituents R 6 and R 7 ; or a pharmaceutically-acceptable salt or stereoisomer thereof.