Patent ID: 8217118

Claim:
A method for preparing a separation matrix, said method comprising reacting together, in a two phase system: a) a matrix having the formula: M-A-H wherein: M is a solid support; A is an atom or group selected from —O—, —S— and —NR 1 —, where R 1 is selected from H and C 1 -C 4 alkyl; and b) a compound of formula: X—(CH 2 ) r —P, wherein: X is selected from chloro, bromo, iodo, C 1 -C 4 alkoxy, mesyl, tosyl and the group: wherein R 2 is selected from H, C 1 -C 4 alkyl, —COOR 3 and aryl; where R 3 is selected from H and C 1 -C 4 alkyl; P is H, or is a ligand selected from C 1 -C 20 alkyl, C 1 -C 20 alkenyl, C 1 -C 20 carboxylic acid ester, C 1 -C 10 alkoxy, C 1 -C 10 alkenyloxy, C 1 -C 10 carboxyalkyl, substituted amino, quaternary ammonium, C 1 -C 20 monoether or polyether having from 1 to 6 oxygen atoms, aryl, aryloxy, heteroaryl and aralkyloxy; and r is 0 or 1; characterised in that said method is performed in the presence of a phase transfer catalyst.