Patent ID: 7253254

Claim:
A bone morphogenetic protein (BMP) or a growth differentiation factor (GDF) polypeptide variant with increased heparin-binding ability, characterized in that (i) added to the amino acid sequence of a BMP or GDF polypeptide is at least one oligopeptide comprising the amino acid sequence X 1 X 2 X 3 X 4 X 5 X 6 ; and/or (ii) inserted into the amino acid sequence of a BMP or GDF polypeptide is at least one oligopeptide comprising the amino acid sequence X 1 X 2 X 3 X 4 X 5 X 6 ; and/or (iii) at least one oligopeptide sequence naturally occurring within the amino acid sequence of a BMP or GDF polypeptide is substituted by an oligopeptide comprising an amino acid sequence X 1 X 2 X 3 X 4 X 5 X 6 , wherein X 1 =K, R, or H; X 2 =K, R, or H; X 3 =K, R, or H; X 4 =not K, R, H, but any other amino acid; X 5 =not K, R, H, but any other or no amino acid; X 6 =not K, R, H, but any other or no amino acid (SEQ ID NO: 1).