Patent ID: 7531192

Claim:
A process for preparing semi-solid oral gel delivery system for drugs comprising the steps of: (a) dispersing an effective amount of one or more drugs in a solvent at or below a temperature of 70° C. to provide a solvent mixture, said solvent comprising glycerol, and optionally one or more other polyhydric alcohols; (b) blending said solvent mixture at a temperature between 50° C. and 80° C. with a blend comprising (i) one or more starches; (ii) optionally one or more other carbohydrates, (iii) one or more hydrocolloids, (iv) one or more sugars, sugar alcohols or sugar syrups, or a combination thereof, and (v) optionally water to provide a flowable matrix in which said one or more drugs are substantially uniformly dispersed; and (c) moulding said matrix and allowing it to cool to provide said semi-solid oral gel delivery system, wherein said oral gel delivery system is flowable at and above a temperature of 45° C., wherein said semi-solid oral gel delivery system is formulated to have a final moisture content of 10% to 30% by weight and a water activity less than 0.7, and comprises between 5% and 35% by weight of said solvent; between 1% and about 15% by weight of said one or more starches, and said optional one or more other carbohydrates; between 0.1% and 7% by weight of said one or more hydrocolloids; between 20% and 60% by weight of said one or more sugars, sugar alcohols, or sugar syrups, or combination thereof, and less than 25% by weight of said one or more drugs.