Patent ID: 7381734

Claim:
A tryptase inhibitor compound of formula (I) where; R 5 represents hydrogen; R 6a represents hydrogen; X—X is CONH; L is CO or CONR 1d (CH 2 ) m in which m is 0 or 1 and R 1d is hydrogen, (1-6C)alkyl or phenyl(1-6C)alkyl; Cy is a group of formula in which one of X a and X b is N and the other is NH or S, and each of R 3r and R 3s is as defined for R 3a ; each R 3a independently is hydrogen, hydroxyl, (1-6C)alkoxy, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkanoyl, (1-6C)alkylaminoalkyl, hydroxy(1-6C)alkyl, carboxy, (1-6C)alkoxyalkyl, (1-6C)alkoxycarbonyl, (1-6C)alkylaminocarbonyl, amino(1-6C)alkyl CONH 2 , CH 2 CONH 2 , aminoacetyl, (1-6C)alkanoylamino, hydroxy(1-6C)alkanoylamino, amino(1-6C)alkanoylamino, (1-6C)alkylamino(1-6C)alkanoylamino, di(1-6C)alkylamino(1-6C)alkanoylamino, (1-6C)alkoxycarbonylamino, amino, halo, cyano, nitro, thiol, 1-6C)alkylthio, (1-6C)alkylsulphonyl, (1-6C)alkylsulphenyl, imidazolyl, hydrazido, (1-6C)alkylimidazolyl, (1-6C)alkylsulphonamido, (1-6C)alkylaminosulphonyl, aminosulphonyl, (1-6C) haloalkoxy, or (1-6C) haloalkyl; and Lp is an alkyl, alkenyl, carbocyclic or heterocyclic group, or a combination of two or more such groups linked by a spiro linkage or a single or double bond or by C═O, O, OCO, COO, S, SO, SO 2 , CONR 1c , NR 1c —CO— or NR 1c linkage (where R 1c is as defined for R 1a ), optionally substituted by one or more oxo or R 3 groups in which R 3 is an amino acid residue, N-(1-6C)alkylaminocarbonyl, N,N-di(1-6C)alkylaminocarbonyl, N-(1-6C)alkylamino(1-6C)alkanoyl, N-(1-6C)alkanoylamino(1-6C)alkanonyl, C-hydroxyamino(1-6C)alkanoyl, hydroxy(2-6C)alkanoylamino(1-6C)alkanoyl, di(1-6C)alkylaminosulfonyl, hydrogen, hydroxyl, (1-6C)alkoxy, (1-6C)alkanoyloxy, (1-6C)alkyl, (2-6C)alkenyl (2-6C)alkynyl, (3-6C)alkenyloxycarbonyl, (1-6C)alkanoyl, amino(1-6C)alkyl, amido (CONH 2 ), amino(1-6C)alkanoyl, aminocarbonyl(1-5C)alkanoyl, hydroxy(1-6C)alkyl, carboxy, hydroxy(1-6C)alkanoyl, (1-6C)alkoxy(1-6C)alkyl, (1-6C)alkoxycarbonyl(1-5C)alkyl, (1-6C)alkoxycarbonyl, (1-6C)alkanoylamino, amino, halo, cyano, nitro, thiol, (1-6C)alkylthio, (1-6C)alkylsulfonyl, (1-6C)alkylsulphenyl or hydrazido; or a physiologically tolerable salt thereof.