Patent ID: 8357401

Claim:
A method of preventing substantial aggregation of particles in a reconstituted pharmaceutical nanoparticle composition comprising nanoparticles comprised of poly(lactic) acid-block-poly(ethylene)glycol copolymer or poly(lactic)-co-poly(glycolic) acid-block-poly(ethylene)glycol copolymer and a therapeutic agent, the method comprising: adding a sugar selected from trehalose and sucrose, and a salt to a formulation comprising the nanoparticles such that the formulation has 10 to 500 mM ionic halide and about 5 to about 15 weight percent sucrose or about 10 to about 20 weight percent trehalose; lyophilizing the formulation to form a lyophilized formulation; reconstituting the lyophilized formulation, wherein the reconstituted composition does not have substantial aggregation of the nanoparticles.