Patent ID: 8114860

Claim:
A method for the treatment and/or alleviation of one or more CNS disorders where the gamma-aminobutyric acid (A) receptor (GABA-A) is involved, selected from the group consisting of: epilepsy, menstruation cycle dependant epilepsy, depression, stress related depression, migraine, tiredness, stress related tiredness, premenstrual syndrome, premenstrual dysphoric disorder, menstrual cycle linked mood changes, menstrual cycle linked memory changes, stress related memory changes, menstrual cycle linked difficulties in concentration, menstrual cycle linked sleep disorders and tiredness, stress sensitivity, concentration difficulties, stress or menstrual cycle linked difficulties in concentration, sleep disorders, loss of impulse control, sedation, memory disturbance, learning disturbance, clumsiness, increased appetite and food cravings, negative mood as tension, irritability, side effects of postmenopausal therapy, and side effects of oral contraceptives, characterized in that the effect on the GABA-A receptor is controlled through administering to a patient in need thereof a substance which inhibits 3alpha-hydroxy-5alpha/beta-steroid action substantially without antagonistic effect on the GABA action on the receptor, wherein the substance is 5alpha-PREGNAN-3beta, 20alpha-DIOL or 5beta-PREGNAN-3beta, 20beta-DIOL.