Patent ID: 7175853

Claim:
A therapeutic system for timed and controlled release of at least one therapeutic active agent to a human or animal organism by means of diffusion through the skin or mucous membrane, said active agent initially being present, for the purpose of manufacture and storage, in a first state in which it is chemically stable and insufficiently permeable for the skin or mucous membrane, whereas it is converted at the application site into a second state by access of moisture, in which state it is suitable for diffusion through the skin or mucous membrane and in which it is taken up by the organism, wherein said active agent in said first state is contained in the system as a pharmaceutically acceptable acid salt which is present dispersed as an undissolved solid and which upon access of emerging skin or mucous moisture and by a basic activating agent, which is likewise contained in the system, is chemically converted into the said second state of a base which is taken up through the skin or mucous membrane into the organism in an accelerated manner and in greater quantities compared to the acid salt form, said basic activating agent is selected from a hydrated but undissolved form of a base consisting of sodium trisilicate, sodium metasilicate, disodium phosphate (secondary sodium phosphate), trisodium phosphate (tertiary sodium phosphate), tripotassium phosphate, magnesium carbonate hydroxide, aluminium magnesium hydroxide sulfate, trisodium citrate dehydrate, magnesium citrate tetradecahydrate, tetrasodium edentate dehydrate, potassium sodium tartrate tetrahydrate and disodium succinate hexahydrate, wherein said basic activating agent has either intercalated or bound water of at least 5% to about 60% in its solid body structure.