Patent ID: 7829674

Claim:
An isolated antibody that binds sphingosine-1-phosphate (S1P) under physiological conditions and which comprises two light chain polypeptides and two heavy chain polypeptides, wherein: a. each light chain polypeptide comprises first, second, and third complementarity determining regions CDRL1, CDRL2, and CDRL3, respectively, wherein: (i) CDRL1 comprises amino acid sequence ITTTDIDDDMN (SEQ ID NO: 10); (ii) CDRL2 comprises amino acid sequence EGNILRP (SEQ ID NO: 11); and (iii) CDRL3 comprises amino acid sequence LQSDNLPFT (SEQ ID NO: 12); and b. each heavy chain polypeptide comprises first, second, and third complementarity determining regions CDRH1, CDRH2, and CDRH3, respectively, wherein: (i) CDRH1 comprises amino acid sequence DHTIH (SEQ ID NO: 13); (ii) CDRH2 comprises amino acid sequence AISPRHDITKYNEMFRG (SEQ ID NO: 31); and (iii) CDRH3 comprises amino acid sequence GGFYGSTIWFDF (SEQ ID NO: 15).