Patent ID: 7838523

Claim:
A compound chosen from compounds of Formula 1: or a pharmaceutically acceptable salt, chelate, or non-covalent complex thereof, wherein R is chosen from optionally substituted aryl and optionally substituted heteroaryl; R 4 is chosen from hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, halo, and hydroxy; R 21 and R 22 are independently chosen from hydrogen and optionally substituted lower alkyl; R 16 is chosen from hydrogen, cyano, optionally substituted cycloalkyl, and optionally substituted lower alkyl; A is chosen from optionally substituted 5-membered heteroaryl, optionally substituted pyridazinyl, optionally substituted pyrimidinyl, and optionally substituted pyrazinyl; L is chosen from optionally substituted C 0 -C 4 alkylene, —O-optionally substituted C 0 -C 4 alkylene, —(C 0 -C 4 alkylene)(SO)—, —(C 0 -C 4 alkylene)(SO 2 )—; and —(C 0 -C 4 alkylene)(C═O)—; and G is chosen from hydrogen, halo, hydroxy, alkoxy, nitro, optionally substituted alkyl, optionally substituted amino, optionally substituted carbamimidoyl, optionally substituted heterocycloalkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl.