Patent ID: 7375213

Claim:
A method of preparing a compound of Formula (I) or a pharmaceutically acceptable complex thereof wherein: R 1 is selected from the group consisting of hydrogen, a hydroxy group, bromine, chlorine, fluorine, an alkyl group, an alkoxy group, an alkylthio group, and an arylthio group, where p is 1 to 4, and with the proviso that bromine, chlorine and fluorine, when present, are only present in at least one of the 3-, 4- and 5-positions; R 2 is selected from the group consisting of hydrogen, a hydroxy group, chlorine, fluorine, an alkyl group, an alkoxy group, and an alkylthio group, where q is 1 to 5; and A is selected from the group consisting of a covalent bond, O, S, NH, and (CH 2 ) n where n is 1 to 3, and with the proviso that when A is in the 4-position, R 1 is not bromine; with the proviso that when one of R 1 is bromine; and if A is in the 3- or 6-position, then bromine is in the 5-position, if A is in the 2- or 5-position, then bromine is in the 3-position, and when bromine is in the 3-position, and A is in the 2- or 5-position, then R 1 groups in the 4- and 6-positions are the same and are not bromine, chlorine or fluorine, and when bromine is in the 5-position, and A is in the 3- or 6-position, then R 1 groups in the 2- and 4-positions are the same and are not bromine, chlorine or fluorine, said method comprising: a) forming a compound of Formula (IV) from a lactone protected with an acid-labile protecting group wherein ALG is an acid labile protecting group, b) glycosidating of the compound of Formula (IV) in the presence of a nucleophilic compound which has an R 3 group, with simultaneous removal of the acid-labile protecting group to form a compound of Formula (V); wherein R 3 is selected from the group consisting of an alkoxy group, an alkenyloxy group, an alkylthio group and an alkenylthio group; c) reacting the compound of Formula (V) with an acylating agent to form a compound of Formula (VI); d) reducing the compound of Formula (VI) to provide a compound of Formula (VII); and e) removing acyl protecting group from the compound of Formula (VII) to provide a compound of Formula (I); wherein R 1 , R 2 , A, p and q are as defined hereinabove, and AC is an acyl protecting group.