Patent ID: 8071797

Claim:
A compound according to formula I wherein: A 1 is phenylene or pyridinylene; A 2 is phenyl or pyridinyl either optionally substituted with 1 to 3 groups independently selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 haloalkyl, cyano and C 1-6 alkoxy; R 1 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, C 1-10 alkoxy or halogen; Y is NR 2 R 3 , C 1-6 hydroxyalkyl, C 1-6 acyl or heteroaryl selected from the group consisting of pyrrolyl, pyrazolyl or isoxazolyl said heteroaryl optionally substituted by one or two groups selected from C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, halogen or pyrrolidinyl wherein the nitrogen atom is optionally substituted by C 1-6 acyl or C 1-6 alkylsulfonyl; either (i) R 2 is (a) hydrogen, (b) C 1-10 alkyl, (c) C 1-10 alkyl substituted by one to four groups selected independently in each occurrence from hydroxy, NR 7b R 8b , C 1-3 alkoxy, halogen or cyano; (d) R 11 S(â•O) m [C(R 5 ) 2 ] 1-6 wherein R 11 is C 1-6 alkyl or NR 7c R 8c ; (e) C 1-3 alkyl-S(â•O) 2 NHâ€”[C(R 5 ) 2 ] 1-6 ; (f) R 7b R 8b NC(â•O)â€”[C(R 5 ) 2 ] 1-6 ; (g) C 3-6 cycloalkyl optionally substituted by â€”OH, C 1-3 alkoxy or â€”NR 7b R 8b ; (h) heterocyclyl; (i) heterocyclyl-C 1-6 alkyl; (j) heteroaryl-C 1-6 alkyl; (k) C 1-6 acyl optionally substituted with C 1-6 alkylsulfonyl; (l) (CH 2 ) p COX 3 wherein p is one to six and X 3 is hydroxy, C 1-6 alkoxy or NR 7c R 8c ; wherein said heterocyclyl moiety is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, azetidinyl, pyrrolidinyl or piperidinyl, oxazolidin-2-on-4-yl and said heteroaryl moiety is pyridinyl or pyrimidinyl and said heterocyclyl or heteroaryl groups are optionally substituted with optionally substituted by â€”OH, C 1-3 alkoxy, C 1-3 alkyl or â€”NR 7b R 8b R 3 is hydrogen, C 1-10 alkyl, S(â•O) 2 R 6 , S(â•O) 2 NR 7a R 8a , C 1-6 acyl or C(â•O)NR 7a R 8a ; or, (ii) R 2 and R 3 together are (CH 2 ) 2 X 1 (CH 2 ) 2 , (CH 2 ) 3-4 S(â•O) 2 , (CH 2 ) 2-3 NR 10 S(â•O) 2 ; R 4 and R 5 are independently in each occurrence hydrogen or C 1-6 alkyl; R 6 is C 1-6 alkyl or C 3-7 cycloalkyl; R 7a and R 8a are (i) independently hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl C 1-6 haloalkyl or (ii) R 7a and R 8a together are (CH 2 ) 2 X 1 (CH 2 ) 2 ; R 7b , R 8b and R 10 are independently hydrogen, C 1-6 alkyl, C 1-6 acyl or C 1-6 alkylsulfonyl, R 7c and R 8c are independently hydrogen or C 1-3 alkyl; R 9 is hydrogen C 1-3 acyl, C 1-3 alkylsulfonyl or C 1-3 alkyl; R 10 is hydrogen or C 1-6 alkyl; X 1 is â€”Oâ€”.â€”NR 9 â€”, â€”S(O) m â€”, (CH 2 ) n ; X 2 is NHR 5 or O; m and n are independently in each occurrence an integer from 0 to 2; or, pharmaceutically acceptable salts thereof.