Patent ID: 8686003

Claim:
A method of treating vascular calcification in a subject, comprising administering one or more compounds having one of the following formula: wherein A 2 represents â€”Nâ€”; wherein A 1 , A 3 , A 4 , A 5 , A 6 , and A 7 each independently represent â€”Câ€”; wherein R c is in the ortho position; wherein the R c , R d , and R e substitutions are each independently chosen from: i) halogen; ii) hydroxyl; iii) C 1 -C 4 alkyl; iv) C 1 -C 4 alkoxy; v) substituted or unsubstituted heterocyclic; vi) substituted or unsubstituted heteroaryl; vii) substituted or unsubstituted aryl; viii) amino; ix) mono-C 1 -C 4 alkylamino; x) di-C 1 -C 4 alkylamino; xi) nitro; and xii) cyano, wherein the compound is not 2,5-dimethoxy-N-(quinolin-3-yl)benzene-sulfonamide; 2-methoxy-5-methyl-N-(pyridine-3-yl)benzenesulfonamide; 2-ethoxy-5-methyl-N-(pyridine-3-yl)benzenesulfonamide; or N-[(3-1H-1,2,4,-triazol-3-ylthio)-4-hydroxyphenyl]-2,5-dimethoxybenzenesulfonamide; and wherein the compounds are TNAP inhibitors.