Patent ID: 7485645

Claim:
A method at inhibiting type 3 17β-hydroxysteroid dehydrogenase, comprising administering a therapeutically effective amount of at least one compound represented by the structural formula: wherein: X is CH; Y is N; G is C(═O); R is selected from the group consisting of alkyl, —OR 4 , aryl, heteroaryl, heteroaryloxy, heterocyclyl, heterocyclyloxy, cycloalkyl, cycloalklyloxy, —N(R 4 ) 2 where the two R 4 moieties can be the same or different, —(CH 2 ) n -aryl, —(CH 2 ) n -heteroaryl, —(CH 2 ) n -heterocyclyl and —(CH 2 ) n -cycloalkyl, wherein each of said alkyl, aryl, heteroaryl, and cycloalkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of alkyl, alkyl, aryl, heteroaryl, —OR 4 , heterocyclyl, heterocyclyloxy, cycloalkyl, cycloalklyloxy, —N(R 4 ) 2 where the two R 4 groups can be the same or different, —C(O)R 4 , and —C(O)N(R 4 ) 2 where the two R 4 moieties can be the same or different; one of a, b, c and d in ring I represents N or N + O − , and the remaining a, b, c and d positions represent C(R 1 ) or C(R 2 ); or each of a, b, c, and d are independently selected from C(R 1 ) or C(R 2 ); R 1 and R 2 can be the same or different, each being independently selected from the group consisting of: H, halo, —CF 3 , —OR 4 , —C(O)R 4 , —OCF 3 , —SR 4 , —S(O) n R 5 , benzotriazol-1-yloxy, tetrazol-5-ylthio, alkynyl, alkenyl wherein said alkenyl can be unsubstituted or optionally substituted with halo, —OR 4 or —C(O)OR 4 , alkyl wherein said alkyl can be unsubstituted or optionally substituted with halo, —OR 4 or —C(O)OR 4 , —N(R 4 ) 2 where the two R 4 moieties can be the same or different, —NO 2 , —OC(O)R 5 , —C(O)OR 4 , —CN, −N(R 4 )C(O)OR 4 , —SR 5 C(O)OR 4 , and —SR 5 N(R 4 ) 2 (provided that R 5 in —SR 5 N(R 4 ) 2 is not —CH 2 —) wherein each R 4 is independently selected; the dotted line between carbon atoms 5 and 6 represents an optional bond, such that when a double bond is present, A and B can be the same or different, each being independently selected from the group consisting of —R 4 , halo, —OR 4 , —C(O)OR 4 , —OC(O)OR 4 or —OC(O)R 4 , and when no double bond is present between carbon atoms 5 and 6, A and B can be the same or different, each being independently selected from the group consisting of (H 2 ), —(OR 5 ) 2 , (H and halo), (dihalo), (H and R 5 ), (R 5 ) 2 , (H and —OC(O)R 4 ), (H and —OR 4 ), (═O), and (H, (═NOR 4 ) or (—O—(CH 2 ) p —O—) wherein p is 2, 3 or 4); R 3 is selected from the group consisting of H, alkyl, alkoxy and alkoxyalkyl; R 4 is selected from the group consisting of H, alkyl, aryl and aralkyl; R 5 is alkyl or aryl; R 6 is H or alkyl; n is a number from 1-4; and q is a number from 1-8; to a patient in need of such inhibition.