Patent ID: 8030518

Claim:
A compound of formula I, wherein G is —O—, —S—, —C(g 1 )(g 2 )-, or —NH—, where g 1 and g 2 are, independently, H, phenyl, halogen, methoxy, halomethyl, methoxymethyl, or C 1 -C 3 alkyl; n=1, 2, or 3; each Ar 1 is independently a 5- to 10-member mono- or bicyclic aromatic group, optionally containing 1-4 heteroatoms selected independently from N, O, and S; R 1 and R 2 are selected, independently, from H, CN, halogen, CH 2 CN, OH, NO 2 , CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , C 1 -C 6 alkyl, OR 8 , C(═O)R 9 , C(═O)OR 10 , OC(═O)R 11 , SR 12 , NR 13 C(═O)R 14 , NR 13 C(═NH)R 14 , C(═O)NR 15 R 16 , CH 2 C(═O)NR 15 R 16 , CH 3 NHC(═NH)—, CH 3 C(═NH)NH—, CH 2 C(═NH)NH 2 , NR 17 R 18 , SO 2 R 19 , N(R 20 ) SO 2 R 2 l, SO 2 NR 22 R 23 , C 3 -C 6 cycloalkyl, C 5 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; U is N or CR′; R′, R 3 , and R 4 are, independently, H, halogen, trifluoromethyl, C 1-6 alkyl, which C 1-6 alkyl group optionally substituted with 1 or 2 groups selected, independently, from OH, halogen, C 1 -C 3 alkyl, OC 1 -C 3 alkyl, or trifluoromethyl; X═O or S; Y is O or S; Z is H, halogen, OH, CN, CH 2 CN, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, O—C 1 -C 6 alkyl, (CH 2 ), C 3 -C 6 cycloalkyl, O—C 3 -C 6 cycloalkyl, 0-(CH 2 )wC3-C6 cycloalkyl, q=1 or 0; R 5 is C 1 -C 6 alkyl, (CHR 6 ), C 3 -C 6 cycloalkyl, (CHR 6 ) w CH 2 C 3 -C 6 CH 2 (CHR 6 ) w C 3 -C 6 cycloalkyl, (CHR 6 ) w C 5 -C 6 cycloalkenyl, CH 2 (CHR 6 ), C 5 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Ar 2 , (CHR 6 ) w Ar 2 , CH 2 (CHR 6 ) w Ar 2 , or (CHR 6 ) w CH 2 Ar 2 , where w -0-3, each Ar 2 is independently a 5- to 10-member mono- or bicyclic aromatic group, optionally containing 1-4 ring heteroatoms selected independently from N, O, and S; R 6 is H or C 1 -C 3 alkyl; and R 8 -R 23 are, independently, H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, (CHR 6 ) w C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, where all alkyl, cycloalkyl, alkenyl, alkynyl, aryl, groups are optionally substituted with one or two substituents selected independently from C 1 -C 3 alkyl, halogen, OH, OMe, CN, CH 2 F, and trifluoromethyl; where, additionally, the alkenyl and alkynyl groups are optionally substituted with phenyl or C 3 -C 6 cycloalkyl; and where all cycloalkyl groups optionally contain one or two ring heteroatoms selected independently from N, O, and S; or a pharmaceutically acceptable salt thereof.