Patent ID: 8487101

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt or N-oxide thereof: wherein Y is C(O) or S(O) 2 ; R 1 is hydrogen, halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, C 1-6 alkoxy, trifluoromethoxy, C 1-6 alkylthio, C 1-6 alkylsulphinyl or C 1-6 alkylsulphonyl; R 2 is halogen, nitro, cyano, C 1-6 alkyl, C 2-6 alkynyl, hydroxy(C 1-6 )alkyl or formyl; and R 3 is selected from the group consisting of formulas (b) and (e): wherein the asterisk (*) identifies the point of attachment of R 3 to the remainder of the compound of formula I; R 4 and R 5 are each independently hydrogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylamino(C 1-6 )alkoxy, C 1-6 alkoxy(C 1-6 )alkyl, C 1-6 alkylthio, C 1-6 alkylsulphonyl, hydroxy, hydroxy(C 1-6 )alkyl, amino(C 1-6 )alkyl, nitro(C 1-6 )alkyl, cyano, trifluoromethyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, azido, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, bis[hydroxy(C 1-6 )alkyl]amino, C 1-6 alkylamino(C 1-6 )alkylamino, arylamino, heteroarylamino, C 2-6 alkylcarbonylamino, C 2-6 alkoxycarbonylamino, [(C 2-6 )alkoxycarbonyl][(C 1-6 )alkyl]amino, bis[(C 2-6 )alkoxycarbonyl(C 1-6 )alkyl]amino, C 2-6 alkoxycarbonylamino(C 1-6 )alkyl or aminocarbonyl; X is a covalent bond, C(O), S(O) 2 , C(O)O or C(O)N(R 7 ); R 6 is hydrogen or trifluoromethyl; or C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkyl-(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which is optionally substituted with one or more substituents selected from the group consisting of: halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, aryloxy, C 1-6 alkylthio, C 1-6 alkylsulphonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, C 2-6 alkylcarbonylamino, C 2-6 alkoxycarbonylamino, C 1-6 alkylsulphonylamino, formyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di(C 1-6 )alkylaminocarbonyl, aminosulphonyl, C 1-6 alkylaminosulphonyl and di(C 1-6 )-alkylaminosulphonyl; and R 7 is hydrogen or C 1-6 alkyl.