Patent ID: 8835482

Claim:
A compound of formula (I) or a stereoisomeric form thereof, wherein R 1 is C 1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy, cycloC 3-7 alkyl, tetrahydropyranyl, tetrahydrofuranyl and phenyl; cycloC 3-7 alkyl; tetrahydropyranyl; tetrahydrofuranyl; 1,3-benzodioxolyl; or phenyl; wherein each phenyl independently is optionally substituted with one or more substituents each independently selected from the group consisting of halo, cyano, C 1-4 alkyl optionally substituted with one or more halo substituents, and C 1-4 alkyloxy optionally substituted with one or more halo substituents; R 2 is hydrogen; cyano; or C 1-4 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of C 1-4 alkyloxy, halo and NR 3 R 4 ; X 1 is CH or N; X 2 is CR 5 or N; R 5 is hydrogen; halo; cyano; C 1-4 alkyloxy; or C 1-4 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy and NR 3 R 4 ; X 3 is CR 6 or N; R 6 is hydrogen; halo; cyano; C 1-4 alkyloxy; or C 1-4 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyloxy and NR 3 R 4 ; wherein each R 3 is independently hydrogen; C 1-4 alkyl; or C 1-4 acyl; wherein each R 4 is independently hydrogen; C 1-4 alkyl; or C 1-4 acyl; provided that no more than two of X 1 , X 2 and X 3 are N; A 1 is CR 7 or N; wherein R 7 is hydrogen, halo or C 1-4 alkyloxy; A 2 , A 3 and A 4 each independently are CH or N; provided that no more than two of A 1 , A 2 , A 3 and A 4 are N; Het 1 is a 5-membered aromatic heterocycle, having formula (a-1), (a-2), (a-3) or (a-4) R 8 is hydrogen or C 1-4 alkyl; R 9 is hydrogen or C 1-4 alkyl; R 10 is hydrogen or C 1-4 alkyl; R 11 is hydrogen or C 1-4 alkyl; R 12 is C 1-4 alkyl; G 1 is O or S; G 2 is CH or N; or a pharmaceutically acceptable addition salt or a solvate thereof.