Patent ID: 8703793

Claim:
A compound of formula I wherein R 1 is phenyl substituted by a group selected from R 11 , R 12 , and R 13 or a combination thereof, or pyridyl substituted by R 11 , in which R 11 is fluorine, tert-butyl, trifluoromethyl or trifluoromethoxy, R 12 is fluorine or trifluoromethyl, R 13 is fluorine, either R 2 is ethyl, propyl or isopropyl, and R 3 is hydrogen, or R 2 is methyl, and R 3 is hydrogen, or R 2 is methyl, and R 3 is methyl, or R 2 is hydrogen, and R 3 is hydrogen, or R 2 and R 3 together and with inclusion of the carbon atom, to which they are attached, form a cyclopentane ring, or R 2 and R 3 together and with inclusion of the carbon atom, to which they are attached, form a cyclohexane ring, either R 4 is isopropyl or isobutyl, and R 5 is hydrogen, or R 4 is methyl, and R 5 is methyl, or R 4 is hydrogen, and R 5 is hydrogen, or R 4 and R 5 together and with inclusion of the carbon atom, to which they are attached, form a cyclopropane, cyclobutane, cyclopentane or cyclohexane ring, either R 6 is fluorine or methoxy, and R 7 is hydrogen, or R 6 is hydroxyl, and R 7 is methyl, or R 6 is hydroxyl, and R 7 is hydrogen, or R 6 and R 7 taken together and with the carbon atom, to which they are bonded, form a carbonyl (>C═O) or oxime (>C═N—OH) group, R 8 is 1-4C-alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentenyl, cyclohexenyl, tetrahydropyranyl, or phenyl substituted by a group selected from R 81 and R 82 or a combination thereof, in which R 81 is fluorine, methyl, trifluoromethyl, methoxy or trifluoromethoxy, R 82 is fluorine or trifluoromethyl, or a tautomer, stereoisomer, mixture thereof or a salt thereof.