Patent ID: 8414958

Claim:
A process for producing an implant having a coating which, in the implanted state, is in at least some of the surface regions which are in at least indirect contact with hard and/or soft tissue, said coating comprising a statin in the form of a pharmaceutically compatible salt which has been derived from an open-chain, biologically active dihydroxy acid form and has at least one further component selected from the group of: of the branched or linear, substituted or unsubstituted, saturated or partly unsaturated C10-C30 alkyl-, alkenyl-, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl- or alkylcycloarylamines or mixtures thereof, and/or at least one water-soluble ionic polymeric component, said process comprising the following steps: (1) preparation of a first suspension or first solution of a dihydroxy acid form of the statin in a suitable solvent; (2) preparation of a second suspension or a second solution of said at least one further component and/or of said water-soluble ionic polymeric component; (3) mixing said first and second solution and/or suspension to form a suspension and/or solution of the statin and of said at least one further component and/or of the statin and of the water-soluble ionic polymeric component and in a precipitating the statin and said at least one further component and/or the statin and the water-soluble ionic polymeric component in a precipitation reaction to form a precipitation product; (4) isolating the precipitation product as a mixed salt; (5) dissolving or suspending this mixed salt in a solvent or suspension medium to form a mixed salt solution or mixed salt suspension; (6) applying the mixed salt solution or mixed salt suspension to the implant surface to be coated by spray application, dropwise application or dipping, and (7) removing the suspension medium or solvent to form a low-water-solubility, statin-containing, dry coating.