Patent ID: 8138226

Claim:
A method of treating a mammal suffering from a disease, condition, or disorder selected from the group consisting of a psychotropic disorder, an anxiety disorder, a generalized anxiety disorder, depression, a post-traumatic stress disorder, an obsessive-compulsive disorder, a panic disorder, a hot flash, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, a psychiatric disorder, a premenstrual dysphoric disorder, a social phobia, a social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and premature ejaculation comprising administering to said mammal a therapeutically effective amount of a compound having structural Formula 1 or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , and R 18 are independently selected from the group consisting of hydrogen and deuterium; R 19 , R 20 , and R 21 are independently selected from the group consisting of —CH 3 and —CD 3 ; provided that said compound of Formula 1 contains at least three deuterium atoms; and provided that deuterium enrichment in said compound of Formula 1 is at least about 1%.