Patent ID: 7704998

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 1; t is 0 and when t is 0 then a direct bond is intended; each Q is each X is nitrogen; each Y is nitrogen; each Z is nitrogen; R 1 is —C(O)NR 7 R 8 , —N(H)C(O)R 9 , —C(O)—C 1-6 alkanediylSR 9 , —NR 10 C(O)N(OH)R 9 , —NR 10 C(O)C 1-6 alkanediylSR 9 , —NR 10 C(O)C═N(OH)R 9 wherein R 7 and R 8 are each independently selected from hydrogen, hydroxy, C 1-6 alkyl, hydroxyC 1-6 alkyl, aminoC 1-6 alkyl or aminoaryl; R 9 is independently selected hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, arylC 1-6 alkyl, C 1-6 alkylpyrazinyl, pyridinone, pyrrolidinone or methylimidazolyl; R 10 is independently selected hydrogen or C 1-6 alkyl; R 2 is hydrogen, halo, hydroxy, amino, nitro, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, di(C 1-6 alkyl)amino, hydroxyamino or naphtalenylsulfonylpyrazinyl; —L— is a direct bond or a bivalent radical selected from C 1-6 alkanediyl, amino, carbonyl or aminocarbonyl; each R 3 represents a hydrogen atom and one hydrogen atom can be replaced by aryl; R 4 is hydrogen, hydroxy, amino, hydroxyC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkyloxy, arylC 1-6 alkyl, aminocarbonyl, hydroxycarbonyl, aminoC 1-6 alkyl, aminocarbonylC 1-6 alkyl, hydroxycarbonylC 1-6 alkyl, hydroxyaminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylaminoC 1-6 alkyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; is wherein each s is independently 0, 1, 2, 3, 4 or 5; each R 5 is independently selected from thiophenyl; thiophenyl substituted with di(C 1-6 alkyl)aminoC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkylpiperazinylC 1-6 alkyl or di(hydroxyC 1-6 alkylaminoC 1-6 alkyl; furanyl; furanyl substituted with hydroxyC 1-6 alkyl; benzofuranyl; or furanyl substituted with —CH═CH—CH═CH—.