Patent ID: 8461167

Claim:
A compound of the Formula I, a tautomer thereof, or a pharmaceutically acceptable salt thereof: wherein: Ring T represents a substituted or unsubstituted 6-membered heteroaryl ring, comprising 2 nitrogens; Ring A represents a 5- or 6-membered aryl or heteroaryl ring and is optionally substituted with 1-4 R a groups; Ring B represents a 5- or 6-membered aryl or heteroaryl ring and is optionally substituted with 1-5 R b groups; L 1 is selected from NR 1 C(O) and C(O)NR 1 ; at each occurrence, R a and R b are independently selected from the group consisting of halo, —CN, —NO 2 , —R 4 , —OR 2 , —NR 2 R 3 , —C(O)YR 2 , —OC(O)YR 2 , —NR 2 C(O)YR 2 , —SC(O)YR 2 , —NR 2 C(═S)YR 2 , —OC(═S)YR 2 , —C(═S)YR 2 , —YC(═NR 3 )YR 2 , —YP(═O)(YR 4 )(YR 4 ), —Si(R 4 ) 3 , —S— or —NR 3 —; R 1 , R 2 and R 3 are independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl and heteroaryl; wherein the —NR 2 R 3 moiety is optionally a 5- or 6-membered saturated, partially saturated or unsaturated ring, which is optionally substituted and which contains 0-2 additional heteroatoms selected from N, O and S(O) r ; each occurrence of R 4 is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl, heteroaryl; (a) X 1 is CH or CR t1 wherein R t1 is halo, OR 5 , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, carbon linked heteroaryl, carbon linked heterocyclyl; wherein R 5 is H, alkyl, alkenyl alkynyl; X 2 is N; and X 3 is CR t4 ; wherein R t4 is H, halo, —CN, —NO 2 , —R 2 , —OR 2 , —C(O)YR 2 , —OC(O)YR 2 , —SC(O)YR 2 , —NR 2 C(═S)YR 2 , —OC(═S)YR 2 , —C(═S)YR 2 , —YC(═NR 3 )YR 2 , —YP(═O)(YR 2 )(YR 2 ), —Si(R 4 ) 3 , —S(O) r R 2 , —SO 2 NR 2 R 3 ; or, (b) X 1 is CR t , X 2 is N and X 3 is CR t3 , wherein R t is selected from —CN, —NO 2 , —OR 6 , —NR 2 R 3 , —C(O)YR 2 , —OC(O)YR 2 , —NR 2 C(O)YR 2 , —SC(O)YR 2 , —NR 2 C(═S)YR 2 , —OC(═S)YR 2 , —C(═S)YR 2 , —YC(═NR 3 )YR 2 , —YP(═O)(YR 4 )(YR 4 ), —Si(R 4 ) 3 , —NR 2 SO 2 R 2 , —S(O) r R 2 , —SO 2 NR 2 R 3 and —NR 2 SO 2 NR 2 R 3 , wherein R 6 is cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, or heterocyclyl and wherein R t3 is selected from H or R a ; (b)-1: at least one of R t , R t3 , R a and R b is or contains a YP(═O)(YR 4 )(YR 4 ), a Si(R 4 ) 3 or —YC(═NR 3 )YR 2 substituent; or (b)-2: at least one of R a and R t is or contains a —NR 2 C(═S)OR 2 , —OC(═S)YR 2 , or —C(═S)OR 2 substituent; or (b)-3: at least one of R b and R t3 is or contains a —NR 2 C(═S)YR 2 , —OC(═S)YR 2 , or —C(═S)YR 2 substituent; each of the foregoing alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl and heterocyclyl moieties are optionally substituted; m is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, 4 or 5; r is 0, 1 or 2.