Patent ID: 7238711

Claim:
A method to modulate the migration or recruitment of leukocytes to a preselected physiological site, comprising: administering to a mammal a dosage form comprising an effective amount of a compound of formula (X): wherein R 1 is (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, (C 1 -C 15 )alkoxy, heteroaryl, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl; and R 2 is hydrogen or (C 1 -C 15 )alkyl; or R 1 and R 2 together with the atoms to which they are attached are a six membered heterocyclic ring comprising five carbon atoms, optionally substituted on carbon with oxo; R 3 is hydroxy, (C 1 -C 6 )alkoxy, or N(R a )(R b ); and R 4 is hydroxy, (C 1 -C 6 )alkoxy, or N(R a )(R b ); or R 3 and R 4 together with the atoms to which they are attached are a five or six membered heterocyclic ring comprising four or five carbon atoms and N(R c ); R 5 is hydrogen or (C 1 -C 6 )alkyl; R 6 is hydrogen or oxo; X is a direct bond, N(H), or methylene (—CH 2 —); each R a and R b is independently hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkoxycarbonyl, aryl, aryl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxy, aryl(C 1 -C 6 )alkanoyl, aryl(C 1 -C 6 )alkoxycarbonyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkoxy, heteroaryl(C 1 -C 6 )alkanoyl, or heteroaryl(C 1 -C 6 )alkoxycarbonyl; and R c is hydrogen or (C 1 -C 6 )alkyl; wherein any (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, or (C 1 -C 15 )alkoxy of R 1 is optionally substituted with one or more substituents selected from the group consisting of halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl, hydroxy, oxo, and N(R a )(R b ); and wherein any aryl, or heteroaryl of R 1 , R a , and R b , is optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of halo, cyano, hydroxy, nitro, trifluoromethyl, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 -C 6 )alkoxycarbonyl, sulfino (SO 2 H), sulfo (SO 3 H), and methylenedioxy; or a pharmaceutically acceptable salt thereof; wherein the dosage form is linked to a site targeting moiety.