Patent ID: 7342039

Claim:
A compound of the formula: or a pharmaceutically acceptable salt or ester form thereof wherein: R 1 is a direct bond to A, or C 1 -C 4 alkylene or —O—C 1 -C 4 alkylene, each optionally substituted with 1 to 3 substituents selected from C 1 -C 4 alkyl, aryl, and benzyl; R 2 and R 3 are, independently hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OH, —NH 2 , —NO 2 , —O(CH 2 ) p -aryl, —O(CH 2 ) p -heteroaryl, aryl, heteroaryl, —NH(CH 2 ) p -aryl, —NH(CH 2 ) p -heteroaryl, —NH(CO)-aryl, —NH(CO)-heteroaryl, —O(CO)-aryl, —O(CO)-heteroaryl, —NH(CO)—CH═CH-aryl, or —NH(CO)—CH═CH-heteroaryl; p is an integer from 0-6; R 4 is hydrogen, C 1 -C 8 alkyl, or C 3 -C 6 cycloalkyl; A is —COOH, tetrazole, tetronic acid, acyl tetronic acid, or a group of the formula: R 10 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, -CH 2 -(C 3 -C 6 cycloalkyl), C 3 -C 6 cycloalkenyl, -CH 2 -(C 3 -C 6 cycloalkenyl), aryl, heteroaryl, aryl(C 1 -C 6 )alkyl, or heteroaryl(C 1 -C 6 )alkyl; X is C 1 -C 8 alkylene, C 3 -C 6 cycloalkylene, —(CH 2 ) m O—, or —(CH 2 ) m NH—; m is an integer from 1-6; and R 5 is hydrogen, C 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, heteroaryl, —CH 2 -heteroaryl, aryl or benzyl; R 6 is C 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, —(CH 2 ) q —CH═CH 2 , —(CH 2 ) q —CH═CH-alkyl, —(CH 2 ) q —CH═C-dialkyl, —(CH 2 ) q C≡CH, —(CH 2 ) q C≡C-alkyl, —(CH 2 ) q -alkyl, —(CH 2 ) q -heteroaryl, —CO-aryl, —CO-heteroaryl, —CO-alkyl, —SO 2 alkyl, —SO 2 -aryl, or —SO 2 -heteroaryl; q is an integer from 0 to 6; R 7 and R 8 , are, independently, hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 perfluoroalkyl, —O—C 1 -C 6 perfluoroalkyl, C 1 -C 6 alkoxy, —OH, —NH 2 , —NO 2 , —O(CH 2 ) n -aryl, —O(CH 2 ) n -heteroaryl, aryl, or heteroaryl; and n is an integer from 0-6, wherein the alkylene, —O-alkylene, alkyl, aryl, heteroaryl and cycloalkyl are each optionally substituted by one or more substituents.