Patent ID: 8217147

Claim:
An antibody having a variant Fc region, or a fragment thereof which comprises said variant Fc region, wherein said variant Fc region comprises amino acid modifications relative to a wild-type Fc region such that said variant Fc region binds FcγRIIIA with a greater affinity relative to an antibody comprisinga the wild-type Fc region and wherein said amino acid modifications are: (A) a substitution at position 243 with leucine, at position 292 with proline, at position 300 with leucine, at position 305 with isoleucine, and at position 396 with leucine; (B) a substitution at position 243 with leucine, at position 292 with proline, at position 300 with leucine, and at position 396 with leucine; or (C) a substitution at position 243 with leucine, at position 292 with proline, and at position 300 with leucine; wherein the positions are numbered according to the EU index as in Kabat.