Patent ID: 8071075

Claim:
A transdermal drug delivery system comprising: (a) a therapeutically effective amount of testosterone; (b) at least one dermal penetration enhancer present in an amount of from 10 to 10,000 wt % based on the weight of the testosterone; wherein the dermal penetration enhancer is at least one ester of formula (I): wherein R 1 is hydrogen, lower alkyl, lower alkoxy, halide, hydroxy or NR 3 R 4 ; R 2 is a C 8 to C 18 alkyl; R 3 and R 4 are each independently hydrogen, lower alkyl or R 3 and R 4 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring; n is 0 or 1, and q is 1 or 2, wherein, when n is 0 and R 1 is NR 3 R 4 , then NR 3 R 4 is para-substituted; and (c) at least one volatile liquid present in an amount to act as a vehicle for the testosterone and penetration enhancer.