Patent ID: 8822510

Claim:
A compound of Formula (I): or a stereoisomer or a salt thereof, wherein: (i) R 1 and R 2 are independently C 1 -C 4 alkyl; or (ii) R 1 and R 2 together with the carbon atom to which they are attached, form a cyclic group selected from adamantanyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.2]octanyl, C 3-7 cycloalkyl, and a 4- to 6-membered heterocycloalkyl, wherein each of said cycloalkyl and heterocycloalkyl rings is substituted with zero to 4 R a ; L 1 and L 2 are each independently: (a) a bond, (b) —(CR b R b ) 1-4 —, (c) —(CH 2 ) 0-3 —CR c ═CR c —(CH 2 ) 0-3 , and/or (d) —(CH 2 ) 0-3 —O(CH 2 ) 1-3 — or —(CH 2 ) 0-3 S(CH 2 ) 1-3 —; Q is: (a) H or C 1-6 alkyl; or (b) phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents independently selected from F, Cl, C 1-3 alkyl, —CN, —NO 2 , —NH 2 , C 1-2 fluoroalkyl, C 1-3 alkoxy, C 1-2 fluoroalkoxy, —NHC(O)(C 1-3 alkyl), —NHC(O)O(C 1-3 alkyl), —NHS(O) 2 (C 1-3 alkyl), and/or —S(C 1-3 alkyl); provided that if Q is H or C 1-6 alkyl, then L 1 is —(CR b R b ) 1-4 —, L 2 is a bond, and R 1 and R 2 together with the carbon atom to which they are attached form cyclohexanone; each R 3 is independently F, Cl, C 1-3 alkyl, C 1-3 alkoxy, —CF 3 , —OCF 3 , —NHC(O)(C 1-3 alkyl), and/or —S(C 1-3 alkyl); G is: (a) —(CR e R e ) a OH, —(CR e R e ) a C(O)OH, —(CR e R e ) a CN, —(CR e R e ) a NH 2 , —(CR e R e ) b CR e (NH 2 )(CR e R e ) a OH, or —(CR e R e ) b CR e (NH 2 )(CR e R e ) a OP(O)(OH) 2 ; (b) —(CR e R e ) b NR f (CR e R e ) b C(O)OH, —(CR e R e ) b C(O)NR f (CR e R e ) a C(O)OH, or —(CR e R e ) b S(O) 2 NR f (CR e R e ) a C(O)OH; (c) —O(CR e R e ) a OH, —O(CR e R e ) a NH 2 , or —O(CR e R e ) a CH(NH 2 )(CR e R e ) b C(O)OH; wherein Y is CH 2 or NH; wherein one of W and Z is CH or N, and the other of W and Z is CH or C(OH), x is 1 or 2; and y is 1 or 2; each R a is independently F, Cl, C 1-3 alkyl, and/or —S(O) 2 R d ; and/or two R a attached to the same carbon atom form ═O; each R b is independently H, —CH 3 , F, Cl, —OH, and/or C 1-3 alkoxy, provided that if one R b is —OH, then the second R b attached to the same carbon is not —OH, F, or Cl; each R is independently H, F, and/or C 1-2 alkyl; R d is phenyl substituted with zero to 2 substituents independently selected from F, Cl, —CH 3 , —CF 3 , —OCH 3 , and/or —OCF 3 ; each R e is independently H, —OH, —CH 3 , and/or —CH 2 OH, provided that if one R e is —OH, then the second R e attached to the same carbon is not —OH; R f is H or —CH 3 ; R g is —(CR e R e ) b OH, —(CR e R e ) b C(O)OH, —(CR e R e ) b CR e (NH 2 )(CR e R e ) b OH, or —(CR e R e ) b CR e (NH 2 )(CR e R e ) b OP(O)(OH) 2 ; each a is independently 1, 2, 3, and/or 4; each b is independently zero, 1, 2, 3, and/or 4; n is zero, 1, 2, or 3; t is zero, 1, or 2; and z is 1, 2, or 3.