Patent ID: 8785486

Claim:
A compound having the formula (I) or a stereochemically isomeric form thereof, wherein R 1 is C 1-6 alkyl; C 3-6 cycloalkyl; trifluoromethyl; C 1-3 alkyl substituted with trifluoromethyl, C 3-7 cycloalkyl, phenyl, or phenyl substituted with C 1-3 alkyl, C 1-3 alkyloxy, cyano, halo, trifluoromethyl; phenyl; phenyl substituted with 1 or 2 substituents selected from the group consisting of C 1-3 alkyl, cyano, halo, trifluoromethyl; or 4-tetrahydropyranyl; R 2 is cyano, halo, trifluoromethyl, C 1-3 alkyl or cyclopropyl; R 3 is a radical of formula (a) or (b) or (d) R 4 is hydroxyC 3-6 cycloalkyl; pyridinyl; pyridinyl substituted with one or two C 1-3 alkyl groups; pyrimidinyl; pyrimidinyl substituted with one or two C 1-3 alkyl groups; phenyl; phenyl substituted with 1 or 2 substituents selected from the group consisting of halo, C 1-3 alkyl, hydroxyC 1-3 alkyl, mono- or polyhaloC 1-3 alkyl, cyano, hydroxyl, carboxyl, C 1-3 alkyloxyC 1-3 alkyl, C 1-3 alkyloxy, mono- or polyhalo-C 1-3 alkyloxy, and morpholinyl; R 5 is hydrogen, fluoro, hydroxyl, hydroxyC 1-3 alkyl, fluoroC 1-3 alkyl, morpholinyl or cyano; X is C or N in which case R 5 represent the electron pair on N; or R 4 —X—R 5 represents a radical of formula (h) or (i) or (j) n is 0 or 1; q is 1 or 2; R 6 is C 1-3 alkyl; C 3-6 cycloalkyl; hydroxyC 2-4 alkyl; (C 3-6 cycloalkyl)C 1-3 alkyl; phenyl; pyridinyl; or phenyl or pyridinyl substituted with one or two substituents selected from the group consisting of halo, C 1-3 alkyl, C 1-3 alkoxy, hydroxyC 1-3 alkyl, trifluoromethyl and (CH 2 ) m —CO 2 H, wherein m=0, 1, or 2; or R 6 is a cyclic radical of formula (k) wherein R 8 is hydrogen, C 1-3 alkyl, hydroxyC 1-3 alkyl; p is 1 or 2; Z is O, CH 2 or CR 9 (OH) wherein R 9 is hydrogen or C 1-3 alkyl; R 7 is hydrogen, halo or trifluoromethyl; Y is a covalent bond, O, NH, S, C(OH)(CH 3 ), —CH 2 —O—, —O—CH 2 —, CHF or CF 2 ; or R 6 —Y is morpholinyl, pyrrolidinyl, or piperidinyl optionally substituted with hydroxyl or hydroxyC 1-3 alkyl; and A is O or NH; or a pharmaceutically acceptable salt thereof.