Patent ID: 7355037

Claim:
A hydroxyl-protected alcohol of the formula Râ€”Oâ€”Pg, wherein Pg is a hydroxyl-protecting group of the formula: wherein: Y is R 1 , OR 1 , or NR 1 R 1a ; Z is O, NR 2 or CR 2 R 2a ; W is CO; R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 and R 4a are the same or different and each is H, a saturated alkyl, an unsaturated alkyl, an aryl, a saturated alkyl with an aryl substituent, or an unsaturated alkyl with an aryl substituent, wherein: any of the alkyl-containing groups for R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 or R 4a is unsubstituted or substituted with one or more substituents, which are the same or different, and selected from the group consisting of a halogen, a saturated alkyl, an unsaturated alkyl, a hydroxyl, an alkoxy, an aryloxy, an aralkoxy, an alkyl carboxylate, an unsaturated alkyl carboxylate, an aryl carboxylate, an amide, a sulfhydryl, an alkyl sulfide, an aryl sulfide, an alkyl sulfoxide, an aryl sulfoxide, an alkyl sulfonyl, an aryl sulfonyl, an alkylcarbonyl, an unsaturated alkyl carbonyl, an aryl carbonyl an alkyl thiocarbonyl, an unsaturated alkyl thiocarbonyl, an aryl thiocarbonyl, a cyano, and a nitro; any of the aryl-containing groups for R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 or R 4a is unsubstituted or substituted with one or more substituents, which are the same or different, and selected from the group consisting of a halogen, a saturated alkyl, an unsaturated alkyl, a hydroxyl, an alkoxy, an aryloxy, an aralkoxy, an alkyl carboxylate, an unsaturated alkyl carboxylate, an aryl carboxylate, an amide, a sulfhydryl, an alkyl sulfide, an aryl sulfide, an alkyl sulfoxide, an aryl sulfoxide, an alkylsulfonyl, an arylsulfonyl, an alkylcarbonyl, an unsaturated alkyl carbonyl, an aryl carbonyl, an alkyl thiocarbonyl, an unsaturated alkyl thiocarbonyl, an aryl thiocarbonyl, a cyano, a nitro, an amino, an alkylamino and a dialkylamino; and optionally, R 1 or R 1a is attached to a solid support; a, b, c, d, e and f are the same or different and each is H, a halogen, a saturated alkyl, an unsaturated alkyl, a hydroxyl, an alkoxy, an aryloxy, an aralkoxy, a cyano, a nitro, a sulfhydryl, an alkyl sulfide, an aryl sulfide, an alkyl sulfoxide, an aryl sulfoxide, an alkylsulfonyl, an arylsulfonyl, an alkylcarbonyl, an unsaturated alkyl carbonyl, an aryl carbonyl, an alkyl thiocarbonyl, an unsaturated alkyl thiocarbonyl, an aryl thiocarbonyl, an alkyl carboxylate, an unsaturated alkyl carboxylate, an aryl carboxylate, an amide, an amino, an alkylamino or a dialkylamino; and R is a nucleosidyl group, an oligonucleotidyl group with 2 to about 300 nucleosides, or an oligomer with 2 to about 300 nucleosides; provided that Y is not OR 1 when Z is O.