Patent ID: 7456190

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R z is hydrogen R; each R y is an optionally substituted C 1-4 aliphatic group Z 1 is N; Z 2 is CH; T (m) R 1 is hydrogen; U is NH; Q is —C(O)N(R)— or —C(O)O—; R 2 is selected from (CH 2 ) y R 5 , (CH 2 ) y CH(R 5 ) 2 , or (CH 2 ) y CH(R 7 )CH(R 5 ) 2 ; y is 0-6; each Ar is independently selected from an optionally substituted 3-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R 3 is selected from hydrogen, CH(R 7 )R 5 , a 3-7 membered carbocyclyl, or an optionally substituted group selected from C 1-4 aliphatic, a 3-6 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered aryl or heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or: two R on the same nitrogen atom are taken together with the nitrogen atom attached thereto to form a 4-8 membered saturated, partially unsaturated, or fully unsaturated ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R 4 is independently selected from R 6 , C(O)R 6 , CO 2 R 6 , CON(R 6 ) 2 , SO 2 R 6 ; each R 5 is independently selected from R 6 , OR 6 , CO 2 R 6 , (CH 2 ) y N(R 4 ) 2 , N(R 4 ) 2 , N(R)C(O)R 6 , N(R)CON(R 6 ) 2 , CON(R 6 ) 2 , SO 2 R 6 , N(R)SO 2 R 6 , C(O)R 6 , CN, or SO 2 N(R 6 ) 2 ; each R 6 is independently selected from R or Ar; R 7 is selected from R 6 , (CH 2 ) w OR 6 , (CH 2 ) w N(R 4 ) 2 , or (CH 2 ) w SR 6 ; and each w is independently selected from 0-4.