Patent ID: 7902355

Claim:
A process for the preparation of an 11-(4-substituted-1-piperazinyl)dibenzo[b,f][1,4]thiazepine, of formula I where A is hydrogen or a —(CH 2 ) 2 —OH group or a —(CH 2 ) 2 —O—(CH 2 ) 2 —OH group, or of a salt thereof, comprising a step in which 10H-dibenzo-[b,f][1,4]-thiazepin-11-one of Formula II, is directly reacted with a piperazine, of Formula III, where A has the same meaning as given above, in the presence of a titanium alkoxide, of the Formula Ti(OR) 4 , where R is a straight or branched alkyl, having one to eight carbon atoms, to obtain said Formula I or a salt thereof.