Patent ID: 8415305

Claim:
Method of treating a subject suffering from a kallikrein 7-dependent disease selected from Netherton's syndrome, pruritic dermatoses and psoriasis, comprising: administering to said subject a therapeutically effective amount of a cyclic depsipeptide, having the structure of formula (I): wherein the ester bond is found between the carboxy group of A7 and the hydroxy group of A2, wherein X and A 1 are each independently optional, and wherein X is chemical residue selected from substituted or unsubstituted aliphatic group, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, or halogen, A 1 is a standard amino acid, A 2 is threonine or serine or 5-methylhydroxyproline, A 3 is a non-basic standard amino acid or a non-basic non-standard amino acid selected from selenocysteine, pyrrolvsine, lanthionine, 2-aminoisobutyric acid, dehydroalanine, 3-amino-6-hydroxy-2-piperidone, gamma-aminobutyric acid, homocysteine, dopamine or hydroxyproline, or a non-basic standard amino acid derivative, A 4 is Ahp, dehydro-AHP, proline or a derivative thereof selected from 3-amino-2-piperidone and ether and ester derivatives of AHP, A 5 is isoleucine, leucine, phenylalanin, prolin, threonine, or valine, A 6 is alanine, phenylalanine, tryptophan, tyrosine or a tyrosine derivative thereof A 7 is leucine, isoleucine or valine, wherein the nitrogen atom of the amid bond between A5 and A6 can be substituted with a methyl or a pharmaceutically acceptable salt of cyclic depsipeptide.