Patent ID: 7256257

Claim:
A compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein, independently at each location: R 1 is hydrogen or lower alkyl; R 2 is hydrogen or lower alkyl; R 3 is lower alkyl; R 4 is lower alkyl, aryl, or —CH 2 —C 5-7 carbocycle when R 5 is H or methyl, or R 4 and R 5 together form a carbocycle of the partial formula —(CR a R b ) n — wherein R a and R b are independently hydrogen or lower alkyl and n is 2, 3, 4, 5 or 6; R 6 is hydrogen or lower alkyl; R 7 is sec-butyl or iso-butyl; R 8 is-hydrogen or lower alkyl; and R 9 is R 11 is hydrogen or lower alkyl; R 12 is lower alkyl, halogen, or methoxy, and m is 0-5 where R 12 is independently selected at each occurrence; and wherein: R 14 is a direct bond, lower alkylene, arylene, or arylene(lower alkylene); R 15 is hydrogen, lower alkyl or aryl; R 16 is arylene(lower alkylene), lower alkylene, arylene, aryl (lower alkylene), or —(CH 2 OCH 2 ) p CH 2 — where p is 1-5; and