Patent ID: 7719273

Claim:
An apparatus for nuclear magnetic resonance measurement comprising: (a) a measurement portion having a magnet for applying a magnetic field to a sample, a bore within the magnet, a nuclear magnetic resonance probe disposed in the bore, and a container for retaining the sample therein, the container being installed in the nuclear magnetic resonance probe and having an injection port and a discharge port for the sample; (b) a mixing filter portion for mixing a small molecule solution with a sample solution and having a first sample transfer tubing connected to the injection port of the container, a second sample transfer tubing connected to the discharge port of the container, an injection port for the small molecule solution, and an injection port and discharge port for the sample, the discharge port being connected to the first sample transfer tubing; (c) a separating filter portion for separating the small molecule solution not containing the sample from the mixed solution of the small molecule and sample, the separating filter portion having a first small molecule solution transfer tubing connected to the small molecule solution injection port of the mixing filter portion, a small molecule discharge port, and a discharge port and injection port for the sample, the injection port for the sample being connected to the second sample transfer tubing; (d) a small molecule concentration controlling portion for controlling the concentration of the small molecule and feeding the small molecule solution, the small molecule concentration controlling portion having a second small molecule solution transfer tubing connected to the small molecule discharge port of the separating filter portion and an injection port and discharge port for the small molecule solution, the injection port being connected to the second small molecule solution transfer tubing and the discharge port being connected to the first small molecule solution transfer tubing; (e) a transmitter/receiver system for transmitting an electromagnetic wave to the nuclear magnetic resonance probe or receiving an electromagnetic wave from the nuclear magnetic resonance probe; (f) a unit for carrying out circulation solution transfer among the small molecule concentration control portion, first small molecule solution transfer tubing, mixing filter portion, first sample transfer tubing, container, second sample transfer tubing, separating filter portion and second small molecule solution transfer tubing; (g) a unit for injecting the small molecule solution; (h) a unit for controlling the small molecule concentration; (i) a unit for injecting the sample solution; (j) a unit for holding the sample solution in the measurement portion; (k) a unit for discharging the sample solution; and (l) a unit for carrying out nuclear magnetic resonance measurement of the sample solution.