Patent ID: 8377937

Claim:
A compound of Formula I: or an enantiomer or salt thereof, wherein: R 1 and R 1a are independently selected from H, Me, Et, vinyl, CF 3 , CHF 2 or CH 2 F; R 2 is H, OH, OMe or F; R 2a is H, Me or F; R 3 is H, Me, Et, or CF 3 ; A is G is phenyl optionally substituted by one to four R e groups or a 5-6 membered heteroaryl optionally substituted by a halogen; R 5 and R 6 are independently H, OCH 3 , C 3 -C 6 -cycloalkyl optionally substituted with F, OH, C 1 -C 3 alkyl or O(C 1 -C 3 alkyl), 4-6 membered heterocycle optionally substituted with F, OH, C 1 -C 3 alkyl, cyclopropylmethyl or C(—O)(C 1 -C 3 alkyl), or C 1 -C 6 -alkyl optionally substituted with one or more groups independently selected from OH, oxo, O(C 1 -C 6 -alkyl), CN, F, NH 2 , NH(C 1 -C 6 -alkyl), N(C 1 -C 6 -alkyl) 2 , cyclopropyl, phenyl, imidazolyl, piperidinyl, pyrrolidinyl, morpholinyl, tetrahydrofuranyl, oxetanyl or tetrahydropyranyl, or R 5 and R 6 together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring optionally substituted with one or more groups independently selected from OH, halogen, oxo, CF 3 , CH 2 CF 3 , CH 2 CH 2 OH, O(C 1 -C 3 alkyl), C(═O)CH 3 , NH 2 , NHMe, N(Me) 2 , S(O) 2 CH 3 , cyclopropylmethyl and C 1 -C 3 alkyl, or R c is hydrogen and R d and R 6 together with the atoms to which they are attached form a 4 to 6 membered heterocyclic ring having one nitrogen atom; R a and R b are H, or R a is H, and R b and R 6 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having one or two ring nitrogen atoms; R c and R d are H or Me, or R c and R d together with the atom to which they are attached from a cyclopropyl ring; each R e is independently halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, O—(C 1 -C 6 alkyl), CF 3 , OCF 3 , S(C 1 -C 6 -alkyl), CN, OCH 2 -phenyl, NH 2 , NO 2 , NH—(C 1 -C 6 -alkyl), N—(C 1 -C 6 -alkyl) 2 , piperidine, pyrrolidine, CH 2 F, CHF 2 , OCH 2 F, OCHF 2 , OH, SO 2 (C 1 -C 6 -alkyl), C(O)NH 2 , C(O)NH(C 1 -C 6 -alkyl), and C(O)N(C 1 -C 6 -alkyl) 2 ; m and n are independently 0, 1, 2 or 3 with the proviso that (m+n) must equal 2, 3 or 4; and p is 0 or 1.