Patent ID: 8563561

Claim:
A compound of formula I in which R 1 denotes Ar, Het, A, CONHA, CONA 2 , OA, OHet, OAr, N(R 5 ) 2 , NR 5 [C(R 5 ) 2 ] n Het, NR 5 [C(R 5 ) 2 ] n Ar, COHet, SO 2 NHA or SO 2 NA 2 , R 2 denotes H, A, Hal, OR 5 , N(R 5 ) 2 , N═CR 5 N(R 5 ) 2 , SR 5 , NO 2 , CN, COOR 5 , CON(R 5 ) 2 , NR 5 COA, NR 5 SO 2 A, SO 2 N(R 5 ) 2 , S(O) m A, Het, [C(R 5 ) 2 ] n N(R 5 ) 2 , [C(R 5 ) 2 ] n Het, O[C(R 5 ) 2 ] n N(R 5 ) 2 , O[C(R 5 ) 2 ] n Het, S[C(R 5 ) 2 ] n N(R 5 ) 2 , S[C(R 5 ) 2 ] n Het, —NR 5 [C(R 5 ) 2 ] n N(R 5 ) 2 , —NR 5 [C(R 5 ) 2 ] n Het, NHCON(R 5 ) 2 , NHCONH[C(R 5 ) 2 ] n N(R 5 ) 2 , NHCONH[C(R 5 ) 2 ] n Het, NHCO[C(R 5 ) 2 ] n N(R 5 ) 2 , NHCO[C(R 5 ) 2 ] n Het, CON(R 5 ) 2 , CONR 5 [C(R 5 ) 2 ] n N(R 5 ) 2 , CONR 5 [C(R 5 ) 2 ] n Het, COHet, COA, O[C(R 5 ) 2 ] n NR 5 COZ, O[C(R 5 ) 2 ] n NR 5 COHet 1 , O[C(R 5 ) 2 ] n Cyc[C(R 5 ) 2 ] n N(R 5 ) 2 , O[C(R 5 ) 2 ] n Cyc[C(R 5 ) 2 ] n OR 5 , O[C(R 5 ) 2 ] n Cyc[C(R 5 ) 2 ] n Het 1 , O[C(R 5 ) 2 ] n CR 5 (NR 5 ) 2 COOR 5 , O[C(R 5 ) 2 ] n NR 5 CO[C(R 5 ) 2 ] n NR 5 COA, O[C(R 5 ) 2 ] n NR 5 COOA, O[C(R 5 ) 2 ] n CO—NR 5 -A, O[C(R 5 ) 2 ] n CO—NR 5 —[C(R 5 ) 2 ] n Het 1 , O[C(R 5 ) 2 ] n CONH 2 , O[C(R 5 ) 2 ] n CONHA, [C(R 5 ) 2 ] n CONA 2 or O[C(R 5 ) 2 ] n CO—NR 5 — [C(R 5 ) 2 ] n N(R 5 ) 2 , Z denotes CR 5 (NR 5 ) 2 CR 5 (OR 5 )A, Cyc denotes cycloalkylene having 3-7 C atoms, R 3 , R 3′ each, independently of one another, denote H, F or A, or together R 3 and R 3′ can also denote alkylene having 2-5 C atoms, R 4 denotes H, A or Hal, R 5 denotes H or A, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are each optionally replaced by OH, F, Cl or Br, and/or in which one or two CH 2 groups are each optionally replaced by O, NH, S, SO, SO 2 or CH═CH groups, or cyclic alkyl having 3-7 C atoms, Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR 5 , N(R 5 ) 2 , SR 5 , NO 2 , CN, COOR 5 , CON(R 5 ) 2 , NR 5 COA, NR 5 SO 2 A, SO 2 N(R 5 ) 2 and/or S(O) m A, Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by Hal, A, OR 5 , N(R 5 ) 2 , SR 5 , NO 2 , CN, COOR 5 , CON(R 5 ) 2 , NR 5 COA, NR 5 SO 2 A, SO 2 N(R 5 ) 2 , S(O) m A, CO-Het 1 , Het 1 , [C(R 5 ) 2 ] n N(R 5 ) 2 , [C(R 5 ) 2 ] n Het 1 , O[C(R 5 ) 2 ] n N(R 5 ) 2 , O[C(R 5 ) 2 ] n Het 1 , NHCOOA, NHCON(R 5 ) 2 , NHCOO[C(R 5 ) 2 ] n N(R 5 ) 2 , NHCOO[C(R 5 ) 2 ] n Het 1 , NHCONH[C(R 5 ) 2 ] n N(R 5 ) 2 , NHCONH[C(R 5 ) 2 ] n Het 1 , OCONH[C(R 5 ) 2 ] n N(R 5 ) 2 , OCONH[C(R 5 ) 2 ] n -Het 1 , CO-Het 1 , CHO, COA, ═S, ═NH, ═NA and/or ═O (carbonyl oxygen), Het 1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which may be mono- or disubstituted by A, OA, OH, Hal and/or ═O (carbonyl oxygen), Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 1, 2, 3 or 4, or a pharmaceutically usable salt, tautomer or stereoisomer thereof, including mixtures thereof in all ratios.