Patent ID: 8034940

Claim:
A compound having the structure an enantiomer, diastereomer, tautomer, or a pharmaceutically-acceptable salt thereof, wherein: X 2 is halogen, alkoxy, H, or alkyl; R x is H, C(O)NR 2 a R 2 b , OR 2 c , R 2 a , COOH, CF 3 , —NHSO 2 R 2 c , aryl, aryloxy, alkylthio, amino, acyl or cyano; R 2 a and R 2 b are the same or different and at each occurrence are independently selected from hydrogen, alkyl, substituted alkyl, C(═O)alkyl, CO 2 (alkyl), SO 2 alkyl, hydrogen, alkenyl, substituted alkenyl, alkoxy, amino, substituted amino, aryl, heteroaryl, heterocyclo, and cycloalkyl; or R 2 a and R 2 b , where possible can be taken together with the nitrogen to which they are attached to form a 5-, 6- or 7-membered heteroaryl or cycloheteroalkyl ring which contains 1, 2 or 3 hetero atoms which can be N, O, or S; R 2 c is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, amino, substituted amino, heteroaryl, heterocyclo, cycloalkyl, and aryl; R 9 and R 10 are the same or different and at each occurrence are independently selected from (i) hydrogen, alkyl, and substituted alkyl or (ii) together with the atom to which they are attached, R 9 and R 10 are taken together to form a cycloalkyl group; R 11 is selected from hydrogen, alkyl, substituted alkyl, C(═O)alkyl, CO 2 (alkyl), SO 2 alkyl, alkoxy, amino, substituted amino, aryl, heteroaryl, heterocyclo, and cycloalkyl; Z is selected from R m and R n are the same or different and at each occurrence are independently selected from hydrogen, halogen, alkoxy, —COR 1 a , —CO 2 R 1 a , C 1-6 alkyl, CF 3 , substituted alkyl, aryl-NHC(O)-aryl, N(R 1 a )(R 1 b ), aryl, arylalkyl, CH 2 OH, —SR 1 a , CH 2 F, cyano, and C 3-6 cycloalkyl; R 1 a at each occurrence is independently selected from hydrogen, alkyl, substituted alkyl, C(═O)alkyl, CO 2 (alkyl), SO 2 alkyl, alkenyl, substituted alkenyl, alkoxy, amino, substituted amino, aryl, and cycloalkyl; and R 1 b is alkyl.