Patent ID: 7250157

Claim:
A composition for treating a disease mediated by perturbations of the NO/cGMP/PKG pathway in a mammal comprising: a) an amount, which is effective to treat a disease mediated by perturbations of the NO/cGMP/PKG pathway in a mammal, of one or more compounds selected from the group consisting of: (i) bicyclic-monoterpene diols, (ii) pharmaceutically acceptable salts of (i), and (iii) prodrugs of (i); and b) a suitable carrier; wherein said disease is selected from the group consisting of heart disease, including stable angina pectoris, unstable angina, myocardial infarction, myocardial failure associated with myocardial ischemia, atherosclerosis, vascular hypertrophy and thrombosis; hypertension; stroke; primary pulmonary hypertension, chronic obstructive pulmonary disease and adult respiratory distress syndrome; microvascular functional abnormalities in diabetes; hemostatic irregularities of glomerular vascular and tubular function; disorders of bladder function and reflex relaxation for micturition; disorders of neurotransmitter release, neuron morphogenesis, synaptic plasticity and neuroendrocrine regulation; regional pain, including migraine headaches; benign anal disease; impotence; inhibition of tumor growth; and stimulation of wound healing.