Patent ID: 6949557

Claim:
A compound of formula (1) wherein R 1 to R 4 are the same or different and represent hydrogen, alkyl, hydroxy, alkoxy, methoxymethyloxy, alkylthio, amino, alkylamino, dialkylamino, alkylcarbonyloxy, NHCOCH 3 , NHCOCF 3 , NH-alkyl, N-dialkyl wherein the alkyl groups may be the same or different or a methylenedioxy group is fused in lieu of either R 1 , R 2 or R 2 , R 3 or R 3 , R 4 position, respectively; R 5 is hydrogen, alkyl or alkoxycarbonyl; M 1 is hydrogen, and M 2 is WR 6 or M 1 and M 2 together represent X; W is oxygen or NH; R 6 is hydrogen, alkyl, alkylcarbonyl, tosyl, COCH(R 7 )NHR 8 , COCH(OR 9 )CH(NHR 8 )phenyl, 2,2-Dimethyl-4-phenyloxazolidine-5-carbonyl or 3-substituted-2,2-dimethyl-4-phenyloxazolidine-5-carbonyl, where 3-substitutents are selected from the group consisting of CO(O-alkyl), CO(O-benzyl) and benzoyl; 2,6-Dioxo-1,2,3,6-tetrahydro-4-carbonyl, 2,6-disubstituted pyrimidine-4-carbonyl wherein the substituents are the same or different and are selected from the group consisting of chloro, fluoro, amino, NH-alkyl, N-dialkyl wherein the alkyl groups are the same or different; NH-aryl; and NH—CH 2 -aryl 4-morpholino, 1-piperidino or 1-pyrolidino; R 7 is hydrogen, alkyl, 4-methylbutyl, benzyl, isopropyl, 1-hydroxyethyl, 2 or 3 or 4-hydroxybenzyl, 2 or 3 or 4-alkoxybenzyl, 3,4-dihydroxybenzyl, 3,4-dialkoxybenzyl, N-[2-hydroxyethyl]-2-aminoethyl, 3,4-methylenedioxybenzyl, 5-amino-4-hydroxy-2-oxocyclohexyl, 2 or 3 or 4-fluorobenzyl, 3-aminopropyl, 4-aminobutyl or indole-3-methyl; R 8 is hydrogen, COCH 3 , COCF 3 , benzoyl or tert.-butyloxycarbonyl, alkyl, 4-methylbutyl, benzyl, isopropyl, 1-hydroxyethyl, 2 or 3 or 4-hydroxybenzyl, 2 or 3 or 4-alkoxybenzyl, 3,4-dihydroxybenzyl, 3,4-dialkoxybenzyl, N-[2-hydroxyethyl]-2-aminoethyl, 3,4-methylenedioxybenzyl, 5-amino-4-hydroxy-2-oxocyclohexyl, 2 or 3 or 4-fluorobenzyl, 3-aminopropyl, 4-aminobutyl or indole-3-methyl; R 9 is hydrogen, COCH 3 , COCF 3 , benzoyl or tert.-butyloxycarbonyl D 1 is H and D 2 is hydrogen, hydroxy or OAc; or D 1 and D 2 together are carboxy, NOR 10 , or NR 11 X, represents NOR 10 or NR 11 ; R 10 is hydrogen or alkyl; and R 11 is alkyl, benzyl, phenyl, 2 or 3 or 4-alkoxyphenyl, 2 or 3 or 4-fluorophenyl, 2 or 3 or 4-bromophenyl, 2,3 or 2,4 or 3,4 or 3,5-dialkoxyphenyl; or a salt thereof.