Patent ID: 7157472

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt or solvate, wherein: m is 2; n is 2; R 1 is 0 to 5 substituents which can be the same or different, each being independently, —OH, halogen, alkyl, haloalkyl, cycloalkyl, —CN, alkoxy, cycloalkoxy, alkylthio-, cycloalkylthio-, —NR 5 R 6 , —NO 2 , —C(O)NR 5 R 6 , —NR 5 C(O)R 6 , —NR 5 C(O)NR 5 R 6 where the two R 5 moieties can be the same or different, —NC(O)OR 7 , —C(O)OR 5 , —SOR 5 , —SO 2 R 5 , —SO 2 NR 5 R 6 , aryl or heteroaryl; R 2 is 0 to 2 subsitutuents which can be the same or different, each being independently, —OH, halogen, alkyl, haloalkyl, cycloalkyl, —CN, alkoxy, cycloalkoxy, alkylthio-, cycloalkylthio-, —NR 5 R 6 , —NO 2 , —C(O)NR 5 R 6 , —NR 5 C(O)R 6 , —NR 5 C(O)NR 5 R 6 where the two R 5 moieties can be the same or different, —NC(O)OR 7 , —C(O)OR 5 , —SOR 5 , —SO 2 R 5 , —SO 2 NR 5 R 6 , aryl or heteroaryl; R 3 is hydrogen or alkyl; R 4 is 0 to 6 substituents which can be the same or different, each being independently alkyl, alkoxy, haloalkyl or —OH; R 5 and R 6 can be the same or different each being independently hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl or cycloalkyl; R 7 is alkyl or cycloalkyl; Z is NR 8 or; R 8 is hydrogen, —SO 2 R 10 , —SO 2 NR 5 R 11 , —C(O)R 11 , —C(O)NR 5 R 11 or —C(O)OR 10 ; R 10 is alkyl, cycloalkyl, aryl or heteroaryl; and R 11 is hydrogen, alkyl, cycloalkyl, aryl or heteroaryl.