Patent ID: 8367640

Claim:
A complex consisting of (1) a polysaccharide substituted with a tryptophan salt and (2) a heparin-binding protein (HBP), wherein the polysaccharide is a dextran functionalized with at least the tryptophan salt: said tryptophan salt being grafted or bound to the polysaccharide via coupling with an acid function, said acid function borne by a linker R bound to the polysaccharide via a function F, said function F resulting from coupling between the linker R and an —OH function of the polysaccharide, F being an ester, thioester, amide, carbonate, carbamate, ether, thioether or amine function, R being a chain containing between 1 and 18 carbon atoms, which is optionally branched and/or unsaturated, containing one or more heteroatoms selected from the group consisting of O, N, S and combinations thereof, and having at least one acid function, Trp being a residue of the tryptophan salt, L- or D-isomer, produced by coupling between the amine of tryptophan and at least one acid borne by the group R, said HBP being selected from the group consisting of: hormones selected from the group consisting of human growth hormone (hGH) and parathyroid hormone (PTH), and growth factors selected from the group consisting of transforming growth factors β1 and 2 (TGF-β), insulin-like growth factor 2 (IGF-2), heparin-binding EGF-like growth factor (HB-EGF), fibroblast growth factors (FGF) of type 1 to 14, keratinocyte growth factor (KGF), nerve growth factor β (NGF-β), connective tissue growth factor (CTGF), placental growth factor (PIGF), R-spondins 1 to 4, and vascular endothelial growth factors A and B (VEGF).