Patent ID: 7041696

Claim:
A compound or its enantiomeric or diasteriomeric form or a pharmaceutically acceptable salt thereof, said compound having the formula: wherein R is a ring chosen from: i) substituted or unsubstituted C 3 –C 10 non-aromatic carbocyclic; ii) substituted or unsubstituted C 6 –C 10 aryl; iii) substituted or unsubstituted C 1 –C 10 heterocyclic; and iv) substituted or unsubstituted C 1 –C 10 heteroaryl; R 1 is a cysteine trap; R 2a , R 2a′ , R 2b , and R 2b′ are each independently hydrogen, hydroxyl, —N(R 6 ) 2 , halogen, C 1 –C 4 alkyl, and C 1 –C 4 alkoxy; or R 2a′ and R 2b′ can be taken together to form a double bond; L and L 1 are linking units each independently having the formula: T, T 1 , and T 2 arc each independently selected from the group consisting of: i) —NR 6 —; ii) —O—; iii) —S(O) 2 —; iv) —NR 6 S(O) 2 —; and v) —S(O) 2 NR 6 —; R 6 is hydrogen, substituted or unsubstituted C 1 –C 10 linear, branched, or cyclic alkyl, C 6 –C 10 aryl, and C 7 –C 12 alkylenearyl; the indices w, w 1 , and w 2 are each independently 0 or 1; R 3a , R 3b , R 4a , and R 4b are each independently: i) hydrogen; ii) C 1 –C 4 linear, branched, and cyclic alkyl; iii) R 3a and R 3b or R 4a and R 4b can be taken together to form a carbonyl unit; and iv) two R 3a or two R 3b units from adjacent carbon atoms or two R 4a or two R 4b units from adjacent carbon atoms can be taken together to form a double bond; the index m is from 0 to 5; the index n is from 0 to 5.