Patent ID: 8536189

Claim:
A compound of Formula (I): or a form thereof, wherein X 1 and X 2 , respectively, are —CH 2 — and —N(R 4 )—; X 3 and X 4 , respectively, are —CH 2 — and —CH 2 —; R 1 is aminoC 1-4 alkyl, R 2 is absent; R 3 is carbonyl, wherein carbonyl is substituted with a substituent selected from the group consisting of; R 8 -furanyl, R 8 -thienyl, and R 8 -benzo[c]thiophenyl, R 8 is an optional substituent on one carbon atom or an available nitrogen atom selected from the group consisting of, R 8a -phenylC 2-4 alkynyl, and an optional substituent on one, two or three carbon atoms each selected from the group consisting of halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 alkylthio; R 8a is one or two optional substituents each selected from the group consisting of halogen, C 1-4 alkyl, and C 1-4 alkoxy; R 4 is one substituent selected from the group consisting of hydrogen, C 1-4 alkyl, carboxyC 1-4 alkyl, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl, C 1-4 alkoxycarbonylC 1-4 alkyl, C 1-4 alkoxycarbonylC 1-4 alkylcarbonyl, C 1-4 alkoxycarbonylcarbonyl, aminocarbonyl, R 9 -phenyl-C 1-4 alkyl, R 9 -phenyl-carbonyl, hydroxysulfonyl, aminosulfonyl, C 1-4 alkylsulfonyl, hydroxysulfonylC 1-4 alkylcarbonyl, C 1-4 alkylsulfonylC 1-4 alkylcarbonyl, C 1-4 alkylsulfonylC 1-4 alkylsulfonyl, C 1-4 alkoxycarbonylC 1-4 alkylsulfonyl, R 9 -phenyl-sulfonyl, P[(O)(OH) 2 ]—C 1-4 alkyl, R 10 -tetrahydrothienyl-sulfonyl, R 11 -1H-tetrazolyl-carbonyl, R 11 -1H-tetrazolyl-C 1-4 alkylcarbonyl and R 11 -1H-imidazolyl-sulfonyl, R 11 -furanyl-sulfonyl, R 11 -thienyl-sulfonyl, wherein C 1-4 alkoxycarbonylC 1-4 alkylcarbonyl is optionally substituted on C 1-4 alkyl with (C 1-4 alkyl)aminoamino; R 9 is one or two optional substituents each selected from the group consisting of C 1-4 alkoxy, carboxy and C 1-4 alkoxycarbonyl; R 10 is an optional (C 1-4 alkyl)aminoamino substituent on one carbon atom, and two oxo substituents on a sulfur atom, when said sulfur atom is present; and R 11 is an optional C 1-4 alkyl substituent on an available nitrogen atom, and an optional substituent on one carbon atom selected from the group consisting of carboxy and C 1-4 alkoxycarbonyl.