Patent ID: 7186402

Claim:
A medicinal aerosol composition comprising: a propellant comprising a hydrofluorocarbon selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, and a mixture thereof; an excipient comprising a compound of the structure X—R 1 —Y-Z; wherein X is selected from the group consisting of: —C(O)OH; —S(O 2 )OH; —OS(O 2 )OH; —P(OH) 2 O; —OP(OH) 2 O; and —N(R 2 )(R 2 ); Y is selected from the group consisting of: —C(O)O—; —OC(O)—; —C(O)—N(R 4 )—; and —N(R 4 )—C(O)—; Z is —R 3 or —R 1 —Y—R 3 ; each R 1 is independently a linear, branched, or cyclic hydrocarbon with 1 to 22 carbons, which may be optionally interrupted by an —O—; each R 2 is independently selected from hydrogen or linear, branched, or cyclic hydrocarbon with 1 to 18 carbons, which may be optionally interrupted by an —O—, —S—, or —N(R 4 )— group, or may be optionally substituted by one or more substituents selected from the group consisting of: —OH; —SH; and —N(R 4 )(R 4 ); R 3 is a linear, branched, or cyclic hydrocarbon with 1 to 20 carbons, which may be optionally interrupted by an —O—, —S—, or —N(R 4 )— group, or may be optionally substituted by one or more substituents selected from the group consisting of: —OH; —SH; and —N(R 4 )(R 4 ); Each R 4 is independently selected from hydrogen or a linear, branched, or cyclic hydrocarbon with 1 to 18 carbons; wherein R 1 and R 4 may optionally be connected together to form an alkylene bridge of from 2 to 4 carbons; and wherein the compound has no more than two amide and/or ester functional groups; and a drug.