Patent ID: 8293910

Claim:
A method for producing a 3,7-diazabicyclo[3.3.1]nonane compound of the formula 1 where R is hydrogen, hydroxyl, C 1 -C 4 -alkyl; R 1 is C 1 -C 4 -alkyl, C 6 -C 10 -aryl, pyridinyl-C 1 -C 4 -alkyl; R 2 is C 1 -C 4 -alkyl, C 6 -C 10 -aryl; R 3 is C 1 -C 4 -alkyl and X is C═O or C(OH) 2 , comprising the steps of (a) reacting a dicarboxylic acid ester of the formula (2) with a pyridinealdehyde of the formula (3) and also an amine of the formula (4) R 2 —NH 2 (4) to give a piperidone of the formula (5) and (b) reacting the piperidones of the formula (5) obtained in this way with formaldehyde and an amine of the formula R 1 —NH 2 , where R, R 1 , R 2 and R 3 are defined above, wherein the reaction stages (a) and (b) are carried out in a C 1 -C 4 -alcohol and the water of reaction that is formed in each case is removed by azeotropic distillation, where, at the same time, a C 1 -C 4 -alcohol is metered in, wherein the reaction stages (a) and (b) are carried out in a one-pot method without isolation of the intermediate product (5).