Patent ID: 7687497

Claim:
An anti-cancer camptothecin analog selected from the group consisting of: 4-Ethyl-4-hydroxy-9-methoxy-11-(2-trimethylsilanyl-ethyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 7-(2′-Trimethylsilanyl)ethyl-10-(methoxymethyl)oxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-(3′-hydroxypropyl)oxy camptothecin; 7-(2′-Trimethethylsilanyl)ethyl-10-(2′-methoxyethoxy)camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-isopropoxy camptothecin; 5-Hydroxy-7-(2′-trimethylsilanyl)ethyl-10-ethoxy camptothecin; 5-Hydroxy-7-(2′-trimethylsilanyl)ethyl-10-amidomethoxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-dimethylcarbamic acid camptothecin; 7-(2′-Trimethylsilanyl) ethyl-10-(ethoxycarbonylmethyl)oxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-(amidomethyl)oxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-(carboxymethyl)oxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-(4-morpholinecarbonyl)oxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-(dimethylthiocarbamoyl)oxy camptothecin; 7-(2′-Trimethylsilanyl) ethyl-10-ethoxy camptothecin; 7-(2′-Trimethylsilanyl)ethyl-10-cyanomethoxy camptothecin; 10-(Trimethylsilanylmethyl)oxy camptothecin, and pharmaceutically-acceptable salts thereof.