Patent ID: 7407964

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, CHN 2 , R, or —CH 2 Y; R is an aliphatic group, an aryl group, an aralkyl group, a heterocyclic group, or a heterocyclylalkyl group; Y is an electronegative leaving group; R 2 is CO 2 H, CH 2 CO 2 H, or an ester of CO 2 H or CH 2 CO 2 H selected from C 1-12 aliphatic esters, aryl esters, aralkyl esters, heterocyclyl esters, heterocyclylalkyl esters, C 1-12 aliphatic amides, aryl amides, aralkyl amides, heterocyclyl amides, and heterocyclylalkyl amides; or R 2 is an isostere of CO 2 H or CH 2 CO 2 H selected from CONHSO 2 (alkyl) and CH 2 CONHSO 2 (alkyl); X 2 -X 1 is N(R 3 )—C(R 3 ) or N═C; each R 3 is independently selected from hydrogen or C 1-6 aliphatic, Ring C is a fused aryl ring, provided that the fused aryl ring has an unsubstituted carbon atom at the position adjacent to the —C(O)—N(—)— group in ring B that is adjacent to the side chain comprising R 1 ; n is 0, 1 or 2; and each methylene carbon in Ring A is optionally and independently substituted by ═O, or by one or more halogen, C 1-4 alkyl, or C 1-4 alkoxy.