Patent ID: 7030246

Claim:
compound of formula (I): wherein: L is CH 2 , O or S; n is 0 or 1; W, Y and Z are, independently hydrogen, cyano, nitro, halogen, N 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 alkylthio, C 3-6 cycloalkyl, CO 2 H, CO 2 (C 1-6 alkyl), CONR 5 R 6 , COR 10 SO 2 R 12 , methylenedioxy, NHCOR 11 or heterocyclyl; R 2 is aryl or heteroaryl optionally substituted by cyano, nitro, halogen, N 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 alkylthio, C 3-6 cycloalkyl, CO 2 H, CO 2 (C 1-6 alkyl), CONR 13 R 14 , COR 15 , SO 2 R 16 , methylenedioxy, NHCOR 17 or heterocyclyl; R 3 is C 1-4 alkyl or C 1-4 haloalkyl; R 4 is CO(C 1-4 alkyl) or CO(C 1-4 haloalkyl); X is O, S, SO, SO 2 , CR 7 R 8 or NR 9 ; R 5 , R 6 , R 7 , R 8 , R 13 and R 14 are, independently, hydrogen or C 1-6 alkyl; R 9 is hydrogen, C 1-6 alkyl or CO(C 1-4 alkyl); R 10 , R 11 , R 12 , R 15 , R 16 and R 17 are, independently, C 1-6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof; or a solvate thereof; provided that the compound of formula (I) is not a compound of formula (Iz): (Iz) wherein R 1b R 1d R 1c R 4′ R 2 R 9 H H H n-butyl C 6 H 5 H H H H n-propyl C 6 H 5 COCH 3 H H H n-propyl C 6 H 5 H H H H Ethyl C 6 H 5 H Br H H Methyl C 6 H 5 COCH 3 Methyl H H Methyl 4-CH 3 —C 6 H 4 H Methyl Methyl H Methyl 2,4-(CH 3 ) 2 —C 6 H 3 H H H H Methyl C 6 H 5 H NO 2 H H Methyl 4-NO 2 —C 6 H 4 COCH 3 NO 2 H H Methyl C 6 H 5 COCH 3 Cl H H Methyl C 6 H 5 COCH 3 H H H Methyl C 6 H 5 COCH 3 H H H Methyl 2,4-Br 2 —C 6 H 3 COCH 3 in free base or unsolvated form.