Patent ID: 8129361

Claim:
An amine compound represented by the following formula (I) wherein R is a hydrogen atom or P(═O)(OH) 2 , X is an oxygen atom or a sulfur atom, Y is —CH 2 CH 2 — or —CH═CH—, Z is alkylene having 1 to 5 carbon atoms, alkenylene having 2 to 5 carbon atoms or alkynylene having 2 to 5 carbon atoms, R 1 is cyano or alkyl having 1 to 4 carbon atoms, which is substituted by a halogen atom, R 2 is alkyl having 1 to 4 carbon atoms, which is optionally substituted by a hydroxyl group or halogen atom, R 3 and R 4 are optionally the same or different and each is a hydrogen atom or alkyl having 1 to 4 carbon atoms, and A is optionally substituted aryl having 6 to 10 carbon atoms, optionally substituted heteroaryl having 5 to 10 ring-constituting atoms, which contains, as ring-constituting atom(s), 1 or 2 atoms from nitrogen atom, oxygen atom and sulfur atom, optionally substituted cycloalkyl having 3 to 7 carbon atoms, which is optionally condensed with optionally substituted benzene, or heterocycloalkyl having 5 to 7 ring-constituting atoms, which contains, as ring-constituting atom(s), optionally substituted 1 or 2 atoms from nitrogen atom and oxygen atom, or a pharmaceutically acceptable acid addition salt thereof.