Patent ID: 8101718

Claim:
A method of administering a porcine partially B-domainless fVIII (OBI-1) to a patient in need of such administration, wherein the OBI-1 is the expression product of SEQ ID NO:1, comprising the steps of: a) obtaining a sample of plasma from the patient; b) measuring the fVIII activity in the sample; c) adding, to aliquots of the plasma sample, varying amounts of the porcine B-domainless fVIII (OBI-1); d) measuring recovery of fVIII activity from said aliquots at a desired time after step c); e) using data from step d), calculating a dose of the porcine partially B-domainless fVIII sufficient to neutralize any preexisting inhibitors to OBI-1 and then calculating a dose to reduce the patient's blood clotting time by a desired value; and f) administering by intravenous infusion the doses calculated in step e) to the patient.