Patent ID: 7332164

Claim:
A compound of the formula: wherein: X 1 -X 6 are independently O, S or NR 1 ; R 44 and R 44′ are independently selected polyalkylene oxides; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, aralkyls, and C 3-8 substituted cycloalkyls; R 40-43 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; y, p, y′ and p′ are independently zero or a positive integer; n and n′ are independently 0 or a positive integer; a and b are independently zero or a positive integer, provided that a+b is greater than or equal to 2; z is a positive integer; D 1 and D 2 are independently selected from the group consisting B, leaving groups, activating groups, and terminal groups, wherein B is selected from the group consisting of biologically active moieties, diagnostic agents and OH; said leaving groups are selected from the group consisting of halogens, activated carbonates, carbonyl imidazole, cyclic imide thiones, isocyanates, N-hydroxysuccinimidyl, para-nitrophenol, N-hydroxyphtalimide, N-hydroxybenzotriazolyl, imidazole, and tosylates; and said terminal groups are selected from the group consisting of: wherein: Y 1-6 are independently selected from the group consisting of O, S or NR 1′ ; R 1′ is selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, aralkyls, and C 3-8 substituted cycloalkyls; R 2-8 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; Ar is a moiety which forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group; L 1-2 are independently selected bifunctional linkers: e and f′ are independently selected positive integers; c, c′ and e′ are independently zero or a positive integer; d, f and d′ are independently zero or one; and B′ is selected from the group consisting of leaving groups, activating groups, OH, biologically active moieties and diagnostic agents wherein said leaving groups are selected from the group consisting of halogens, activated carbonates, carbonyl imidazole, cyclic imide thiones, isocyanates, N-hydroxysuccinimidyl, para-nitrophenol, N-hydroxyphtalimide, N-hydroxy-benzotriazolyl, imidazole, and tosylates provided that n and n′ are positive integers when both a and b are positive integers.