Patent ID: 8895543

Claim:
A method for treating a condition selected from the group consisting of leukemia, carcinoma of the breast, lymphosarcoma, ovarian cancer, squamous cell cancer of the lung, and Hodgkin's disease in mammals comprising: administering to a mammal a therapeutically effective amount of the compound of Formula (I) as follows: where: R 1 is: alkyl; alkenyl; alkynyl; aryl; 3-methylpyrazol-1-yl; pyridyl; thienyl; thiazolyl; piperidinyl; morpholinyl; pyrrolidinyl; azetidinyl; Cl; Br; F; CN; C(O)NR 5 R 6 ; C(O)NHR 5 ; C(O)NH 2 ; C(O)NHNH 2 ; C(O)NR 5 NH 2 ; C(O)NR 5 NHR 6 ; C(O)NR 5 NR 6 R 7 ; C(O)NHNHR 5 ; C(O)NHNR 5 R 6 ; C(O)NHOH; SO 2 NHNH 2 ; SO 2 NR 5 NH 2 ; SO 2 NR 5 NHR 6 ; SO 2 NR 5 NR 6 R 7 ; SO 2 NHNHR 5 ; SO 2 NHNR 5 R 6 ; CO 2 R 5 ; SR 5 ; SSR 5 ; SO 2 NHR 5 ; SO 2 NR 5 R 6 ; B(OR 5 ) 2 ; CF 3 ; SH; SO 2 NH 2 ; NH 2 ; NHR 5 ; NHSO 2 R 5 ; NR 5 R 6 ; NHCOR 5 ; NR 5 COR 6 ; or NR 5 SO 2 R 6 ; R 2 =alkyl or CH(O); R 3 =hydrogen, alkyl, or C(O)R 5 ; R 4 =hydrogen or C(O)R 5 ; R 5 , R 6 and R 7 each are independently alkyl, alkenyl, alkynyl, or aryl; R 8 =hydrogen, halogen, alkyl, alkenyl, alkynyl, aryl, acyl, or thioalkyl; R 9 ═OH and R 10 ═H or R 9 and R 10 together form a bridging double bond; R 5 and R 6 can form a ring or R 6 and R 7 can form a ring; X═OR 5 , NR 5 R 6 , NHNH 2 , NHNHC(O)R 5 , OH, NHR 5 , NH 2 , or NHNHC(O)H; R 4 and X can be linked together with intervening atoms to form a ring; R 1 and R 8 can be linked together; or a pharmaceutically acceptable salt thereof, wherein the alkyl and alkenyl groups can be branched or straight, with the proviso, that when R 8 ═H, R 9 ═OH, and R 10 ═H, then R 1 ≠Br and the proviso that if R 1 is an unsubstituted aryl, then R 2 ≠CH 3 .