Patent ID: 8653105

Claim:
A compound represented by formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof: wherein E represents (methyl)methylene; Q represents N—R 4 ; M represents the residue of a piperazin-1-yl moiety, optionally substituted by one or more substituents independently selected from heteroaryl, hydroxy, hydroxy(C 1-6 )alkyl, oxo, C 2-6 alkylcarbonyl, hydroxy(C 1-6 )alkylcarbonyl, di(C 1-6 )alkylamino(C 1 - 6 )alkylcarbonyl, (C 3-7 )cycloalkylcarbonyl, carboxy, carboxy(C 1-6 )alkyl, C 2-6 alkoxycarbonyl, hydroxy(C 1-6 )alkylcarbonylamino, (C 3-7 )cycloalkylcarbonylamino, aminocarbonyl, aminocarbonyl(C 1-6 )alkyl, C 1-6 alkylaminocarbonyl and (C 1-6 )alkylaminocarbonyl(C 1-6 )alkyl; R 1 and R 2 independently represent hydrogen, halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, C 3-7 cycloalkyl(C 1-6 )alkyl, C 3-7 heterocycloalkyl(C 1-6 )alkyl, aryl(C 1-6 )-alkyl, heteroaryl(C 1-6 )alkyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, C 2-6 alkylcarbonylamino, C 2-6 alkoxycarbonylamino, C 1-6 alkylsulfonylamino, formyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di(C 1-6 )alkylaminocarbonyl, aminosulfonyl, C 1-6 alkylaminosulfonyl or di(C 1-6 )alkylaminosulfonyl; X represents N or CH; and R 16 and R 17 independently represent hydrogen, C 1-6 alkyl, amino, C 1-6 alkylamino or di(C 1-6 )alkylamino.