Patent ID: 8658776

Claim:
A method for preparing a 3′-deoxythymidine support structure, the method comprising: (a) esterifying 3-fluoro-6-nitrobenzoic acid, to obtain an ester intermediate; (b) reacting the ester intermediate with 2-mercaptoethanol to obtain a thioether intermediate; (c) reacting 1-(5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4-dione with the thioether intermediate to obtain a third intermediate; (d) subjecting the third intermediate to saponification to obtain a saponified intermediate; and (e) coupling the saponified intermediate to a solid support, thereby obtaining a precursor for the 3′-deoxythymidine support structure.