Patent ID: 8562988

Claim:
A method of treating a B-cell cancer comprising: a) obtaining a complex consisting essentially of; iii) an antibody moiety that binds to a CD74 dendritic cell antigen, wherein the antibody moiety is attached to a DDD (dimerization and docking domain) moiety, wherein the amino acid sequence of the DDD moiety is selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 2; and iv) a tumor antigen moiety that is a CD20 xenoantigen, wherein the antigen moiety is attached to an AD (anchor domain) moiety, wherein the amino acid sequence of the AD moiety is selected from the group consisting of SEQ ID NO:3; SEQ ID NO:4; SEQ ID NO:7; SEQ ID NO:8; SEQ ID NO:9; SEQ ID NO:10; SEQ ID NO:11; SEQ ID NO:12; SEQ ID NO:13; SEQ ID NO:14; SEQ ID NO:15 and SEQ ID NO:16; wherein two copies of the DDD moiety form a dimer that binds to the AD moiety to form the complex; and b) administering the complex to a human subject with a B-cell cancer.