Patent ID: 8747888

Claim:
A non-heat sealed transdermal drug delivery device that comprises: (a) a polymer matrix active ingredient (AI) layer having a skin-contacting surface and a non-skin contacting surface; the AI layer comprising an active-ingredient, a pressure sensitive adhesive (PSA), and at least one volatile component which is at least partly solubilized in the PSA of the AI layer; (b) a release liner in direct contact with the skin-contacting surface of the AI layer, the perimeter of which extends beyond the perimeter of the AI layer in all directions; and (c) an overlay adjacent to the non-skin contacting surface of the AI layer, the perimeter of which extends beyond the perimeter of the AI layer in all directions; the overlay comprising: (i) a PSA layer, (ii) a polymeric intermediate layer, and (iii) an overlay covering; and (d) an internal backing layer between the AI layer and the overlay; in which device: the release liner and the PSA layer of the overlay are in direct contact with and adhered to each other around the perimeter of the AI layer to form a PSA seal between the overlay and the release liner; the polymeric intermediate layer of the overlay is disposed between the PSA layer of the overlay and the overlay covering, and prevents flow of the PSA of the PSA layer of the overlay into the overlay covering; and the solubility of the volatile component in the PSA of the PSA layer of the overlay is less than the solubility of the volatile component in the PSA of the AI layer; the volatile component is selected from ethyl lactate, Dimethyl sulfoxide (DMSO), or a combination thereof; the PSA of the AI layer is a polyacrylate PSA; and the PSA of the PSA layer of the overlay is a polyisobutylene PSA (PIB PSA), wherein adhesion of the AI layer is achieved without heat sealing.