Patent ID: 7705055

Claim:
A method of treating an epileptic condition in a mammal, comprising administering to said mammal an effective amount of a selective persistent sodium channel antagonist, wherein said antagonist has at least 20-fold selectivity for a persistent sodium current relative to a transient sodium current, and wherein said antagonist is a compound included in formula 3, or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof: wherein, Ar 7 is phenyl or a substituted phenyl; X is O; R 17 and R 18 are independently selected from the group consisting of hydrogen, hydroxy, and a C 1 to C 8 alkyl; R 19 and R 20 are independently selected from the group consisting of hydrogen, hydroxy, and a C 1 to C 8 alkyl; R 21 is selected from the group consisting of hydrogen, hydroxy, and a C 1 to C 8 alkyl; R is a is 0 or 1; and m is 0, 1, 2, or 3.