Patent ID: 7998969

Claim:
A compound according to formula I wherein: R 1 is CO 2 -tert-Bu, phenyl C 1-3 alkyl, heteroaryl C 1-3 alkyl, phenyl or heteroaryl wherein said heteroaryl group is selected from the group consisting of pyridinyl, pyridine-N-oxide, pyrimidinyl, thiophenyl, pyrrolyl, thiazolinyl, imidazolinyl or quinolyl and said phenyl or said heteroaryl is optionally substituted with one to three groups independently selected from the group consisting of: (a) C 1-6 alkyl, (b) C 1-6 alkoxy, (c) C 1-6 haloalkyl, (d) C 1-6 haloalkoxy, (e) carboxyl, (f) CONR 7a R 7b , (g) C 1-6 alkoxycarbonyl, (h) cyano, (i) SO 2 —C 1-6 alkyl, (j) SO 2 NR 8a R 8b , (k) halogen, (l) nitro, (m) C 1-3 cyanoalkyl, (n) NR 10a R 10b , (o) NR 10a SO 2 C 1-6 alkyl, (p) CHR 11a R 11b COR 12 , (q) hydroxyl, and (r) C 1-6 heteroalkyl; R 2 is —CN, —CH═CHCN, C 1-3 alkyl or halogen; R 3 is hydrogen, halogen, amino or C 1-6 haloalkyl; R 4 is hydrogen or amino; R 5a and R 5b are independently hydrogen, C 1-6 alkyl, C 1-6 alkoxy or halogen; R 6a and R 6b independently are hydrogen or together are ethylene; R 7a and R 7b (i) taken independently, one of R 7a and R 7b is hydrogen, C 1-6 alkyl or C 3-7 cycloalkyl and the other of R 7a and R 7b is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 1-6 alkylsulfonyl, C 1-6 hydroxyalkyl, C 1-3 aminoalkyl-C 1-6 alkyl, C 1-3 dialkylamino-C 1-6 alkylalkyl and C 1-6 aminoalkyl; (ii) taken together with the nitrogen atom to which they are attached, form an azetidine, pyrrolidine, piperidine or azepine ring said azetidine, pyrrolidine, piperidine or azepine ring optionally substituted with hydroxy, amino, C 1-3 alkylamine or C 1-3 dialkylamine; or, (iii) taken together are (CH 2 ) 2 —X 1 —(CH 2 ) 2 ; R 8a and R 8b (i) taken independently, one of R 8a and R 8b is hydrogen or C 1-6 alkyl and the other of R 8a and R 8b is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 acyl and C 1-6 heteroalkyl; (ii) taken together with the nitrogen atom to which they are attached, form an azetidine, pyrrolidine, piperidine or azepine ring said azetidine, pyrrolidine, piperidine or azepine ring optionally substituted with hydroxy, amino, C 1-3 alkylamine or C 1-3 dialkylamine; or, (iii) taken together are (CH 2 ) 2 —X 1 —(CH 2 ) 2 ; R 9 is hydrogen, C 1-3 alkyl or C 1-3 acyl; R 10a and R 10b are independently hydrogen, C 1-3 alkyl or C 1-6 acyl; R 11a is hydrogen or halogen; R 11b is hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy or C 1-6 hydroxyalkyl; R 12 is hydroxyl, C 1-6 alkoxy or NR 7a R 7b ; X is NH or O; X 1 is O, S(O)p or NR 9 p is an integer from 0 to 2; or, pharmaceutically acceptable salts thereof.