Patent ID: 8399419

Claim:
A compound having the following structure (I): or a stereoisomer, or pharmaceutically acceptable salt thereof, wherein: Q 1 is hydroxyl, a protected hydroxyl, amino or a protected amino group; Q 2 is hydrogen, alkyl optionally substituted with one or more halogen, hydroxyl or amino, or each R 1 and R 2 is, independently, hydrogen or an amino protecting group; each R 3 is, independently, hydrogen or a hydroxyl protecting group; each R 4 , R 5 , R 7 and R 8 is, independently, hydrogen or C 1 -C 6 alkyl optionally substituted with one or more halogen, hydroxyl or amino; each R 6 is, independently, hydrogen, halogen, hydroxyl, amino or C 1 -C 6 alkyl; or R 4 and R 5 together with the atoms to which they are attached can form a heterocyclic ring having from 4 to 6 ring atoms, or R 5 and one R 6 together with the atoms to which they are attached can form a heterocyclic ring having from 4 to 6 ring atoms, or R 4 and one R 6 together with the atoms to which they are attached can form a carbocyclic ring having from 3 to 6 ring atoms, or R 7 and R 8 together with the atom to which they are attached can form a heterocyclic ring having from 4 to 6 ring atoms; each R 9 is, independently, hydrogen, hydroxyl, amino or C 1 -C 6 alkyl; each R 10 is, independently, hydrogen, halogen, hydroxyl, amino or C 1 -C 6 alkyl; or R 9 and one R 10 together with the atoms to which they are attached can form a heterocyclic ring having from 4 to 6 ring atoms; n is an integer from 0 to 4; Z 1 and Z 2 are both hydrogen or Z 1 and Z 2 form a double bond; and Z 3 and Z 4 are both hydrogen or Z 3 and Z 4 form a double bond.