Patent ID: 7816367

Claim:
A compound having the formula (I): or a pharmaceutically acceptable salt, or ester thereof, wherein Q is heteroaryl L 1 is a bond; P is an aromatic ring; L 2 is oxymethylene or thiomethylene; M is an aromatic ring; X is CR 3 R 4 ; L 3 is (C 1 -C 5 )alkylene; A is —CO 2 H; R 1 is (C 1 -C 6 )alkyl, aryl(C 1 -C 3 ) alkyl or (C 2 -C 6 )heteroalkyl; R 3 is cyano, aryl, heteroaryl, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 3 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 8 )alkynyl, —NR 8 R 9 , —C(O)NR 10 R 11 , —NR 12 C(O)R 13 or —NR 12 S(O) p R 13 ; R 4 is hydrogen, cyano, aryl, heteroaryl, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl or (C 2 -C 8 )alkynyl; R 8 and R 9 are independently hydrogen, (C 1 -C 5 )alkyl, oxy(C 1 -C 5 )alkyl or carboxy(C 1 -C 5 )alkyl; optionally, R 8 and R 9 are combined to form a 4-, 5-, 6- or 7-membered ring containing the nitrogen atom to which they are attached and from 0 to 2 additional heteroatoms selected from N, O and S; R 10 , R 11 and R 12 are independently selected from hydrogen, aryl, heteroaryl, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 3 -C 8 )cycloalkyl and (C 3 -C 8 )heterocycloalkyl; optionally, R 10 and R 11 are combined to form a 4-, 5-, 6- or 7-membered ring containing the nitrogen atom to which they are attached and from 0 to 2 additional heteroatoms selected from N, O and S; R 13 is aryl, heteroaryl, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, (C 3 -C 8 )cycloalkyl or (C 3 -C 8 )heterocycloalkyl; the subscript p is 1 or 2; and wherein the aromatic rings, aryl groups, and heteroaryl groups set forth above are optionally substituted with substituents selected from -halogen, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO 2 , —CO 2 R′, —CONR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″C(O) 2 R′, —NR′—C(O)NR″R″′, —NH—C(NH 2 )═NH, —NR′C(NH 2 )═NH, —NH—C(NH 2 )═NR′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR′R″, —N 3 , —CH(Ph) 2 , perfluoro(C 1 -C 4 )alkoxy, and perfluoro(C 1 -C 4 )alkyl, in a number ranging from zero to the total number of open valences on the aromatic, aryl, or heteroaryl ring; and further wherein R′, R″ and R″′ are independently selected from hydrogen, (C 1 -C 8 )alkyl and heteroalkyl, unsubstituted aryl and heteroaryl, (unsubstituted aryl)-(C 1 -C 4 )alkyl, and (unsubstituted aryl)oxy-(C 1 -C 4 )alkyl.