Patent ID: 7323440

Claim:
A (poly)peptide construct consisting of two domains, a first and a second domain, wherein the first domain comprises a de-immunized, autoreactive antigen specifically recognized by Ig receptors of autoreactive B-cells and wherein the second domain comprises an effector molecule capable of interacting with or activating NK-cells, T-cells, macrophages, monocytes or granulocytes, wherein said first domain comprising a de-immunized, autoreactive antigen is de-immunized myelin oligodendrocyte glycoprotein (eMOG) and the second domain comprising an immunological effector molecule is an Fc-part of an immunoglobulin, and wherein said (poly) peptide construct is encoded by: (a) a polynucleotide comprising a nucleic acid molecule encoding the (poly)peptide as depicted in SEQ ID NO. 28; or (b) a polynucleotide comprising a nucleic acid molecule comprising the DNA sequence as depicted in SEQ ID NO. 27.