Patent ID: 7615383

Claim:
A method for treating a diabetic neuropathy, a cisplatin-induced neuropathy, a pyridoxine-induced neuropathy, or a cisplatin/pyridoxine-induced neuropathy in a mammal suffering therefrom, comprising administering to a mammal an effective amount of an agonist anti-trkC monoclonal antibody which has the ability to bind and activate a trkC receptor tyrosine kinase and which (a) shows substantially no cross-reactivity with trkA or trkB; and (b) recognizes an epitope in domain 5 of trkC, wherein said agonist antibody comprises an anti-trkC antibody heavy chain comprising the following CDRs: (a) a CDR1 defined by SEQ ID NO: 3; (b) a CDR2 defined by SEQ ID NO: 8; and (c) a CDR3 defined by SEQ ID NO: 14, and a human anti-trkC antibody light chain comprising the following CDRs: (a) a CDR1 defined by SEQ ID NO: 21; (b) a CDR2 defined by SEQ ID NO: 28; and (c) a CDR3 defined by SEQ ID NO: 34, wherein said agonist anti-trkC antibody binds trkC effective to activate a trkC receptor tyrosine kinase.