Patent ID: 7202261

Claim:
A method of treating a patient comprising the step of administering to the patient a therapeutically effective amount of a compound having the formula: wherein R 1 is selected from the group consisting of: heteroaryl and heterocycloalk; R 2 is selected from the group consisting of: lower alk, cycloalk, alkoxy, H, OH, ═O, C(O)OH, C(O)O-lower alk, C(O)NH-lower alk, C(O)N(lower alk) 2 , SH, S-lower alk, NH 2 , NH-lower alk, and N(lower alk) 2 ; R 3 and R 4 is each independently lower alk or together cyclopropyl; R 5 is aryl; R 6 if present is either hydrogen, lower alkyl or lower alkenyl, wherein R 6 is not present if R 2 is ═O; Y 1 is either covalent bond, alkylene, or alkenylene; Y 2 is alkylene; Y 3 is alkylene; Z is selected from the group consisting of: covalent bond, O, S, NH, N-lower alk, alkylene, alkenylene, and alkynylene, provided that if Z is either O, S, NH, or N-lower alk, then Y 1 is not a covalent bond; further provided that Y 1 and Z may together be a covalent bond; and pharmaceutically acceptable salts and complexes thereof; except for the following compounds: N-[(2R)-hydroxy-3-[[2-cyano-4-[[4-ethylcarboxyl]phenyl]-3-pyridyloxy]propyl]]-1,1-dimethyl-2-(5-chlorothienyl)ethylamine; N-[(2R)-hydroxy-3-[[2-cyano-4-[[4-carboxyl]phenyl]-3-pyridyloxy]propyl]]-1,1-dimethyl-2-(5-chlorothienyl)ethylamine; N-[(2R)-hydroxy-3-[[2-cyano-4-[[4-ethylcarboxyl]phenyl]-3-pyridyloxy]propyl]]-1,1-dimethyl-2-(indan-2-yl)ethylamine; N-[(2R)-hydroxy-3-[[2-cyano-4-[[4-carboxyl]phenyl]-3-pyridyloxy]]-1,1-dimethyl-2-(indan-2-yl)ethylamine; N-[(2R)-hydroxy-3-[[2-cyano-4-[[4-ethylcarboxyl]phenyl]-3-pyridyloxy]propyl]]-1,1-dimethyl-4-(methoxyphenyl)ethylamine; N-[(2R)-hydroxy-3-[[2-cyano-4-[[4-carboxyl]phenyl]-3-pyridyloxy]propyl]]-1,1-dimethyl-4-(methoxyphenyl)ethylamine; wherein the patient has a disease or disorder characterized by one or more of the following: (1) an abnormal bone or mineral homeostasis; (2) an abnormal amount of an extracellular or intracellular messenger which is ameliorated by a compound able to effect one or more calcium receptor activities; or (3) an abnormal effect of an intracellular or extracellular messenger which is ameliorated by a compound able to affect one or more calcium receptor activities.