Patent ID: 7244850

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof: wherein R F1 and R F2 are independently C 1-6 alkyl substituted by one or more groups selected from —F, —Cl, —Br, —NO 2 , —CN, —OH, —CHO, —C(═O)—R′ and —OR′, wherein R′ is a C 1-3 alkyl; Z is selected from O═ and S═; R 1 is selected from C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, R 3 R 4 N—C 1-6 alkyl, R 3 O—C 1-6 alkyl, R 3 C(═O)N(—R 4 )—C 1-6 alkyl, R 3 R 4 NS(═O) 2 —C 1-6 alkyl, R 3 CS(═O) 2 N(—R 4 )—C 1-6 alkyl, R 3 R 4 NC(═O)N(—R 5 )—C 1-6 alkyl, R 3 R 4 NS(═O) 2 N(R 5 )—C 1-6 alkyl, C 6-10 aryl-C 6-10 alkyl, C 6-10 aryl-C(═O)—C 1-6 alkyl, C 3-10 cycloalkyl-C 1-6 alkyl, C 4-8 cycloalkenyl-C 1-6 alkyl, C 3-6 heterocyclyl-C 1-6 alkyl, C 3-6 heterocyclyl-C(═O)—C 1-6 alkyl, R 3 R 4 N—, R 3 O—, R 3 C(═O)N(—R 4 )—, R 3 R 4 NS(═O) 2 —, R 3 CS(═O) 2 N(—R 4 )—, R 3 R 4 NC(═O)N(—R 5 )—, R 3 R 4 NS(═O) 2 N(R 5 )—, C 6-10 aryl, C 6-10 aryl-C(═O)—, C 3-10 cycloalkyl, C 4-8 cycloalkenyl, C 3-6 heterocyclyl and C 3-6 heterocyclyl-C(═O)—; wherein said C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 6-10 aryl-C 1-6 alkyl, C 6-10 aryl-C(═O)—C 1-6 alkyl, C 3-10 cycloalkyl-C 1-6 alkyl, C 4-8 cycloalkenyl-C 1-6 alkyl, C 3-6 heterocyclyl-C 1-6 alkyl, C 3-6 heterocyclyl-C(═O)—C 1-6 alkyl, C 1-10 hydrocarbylamino, C 6-10 aryl, C 6-10 aryl-C(═O)—, C 3-10 cycloalkyl, C 4-8 cycloalkenyl, C 3-6 heterocyclyl or C 3-6 heterocyclyl-C(═O)— used in defining R 1 is optionally substituted by one or more groups selected from halogen, cyano, nitro, methoxy, ethoxy, methyl, ethyl, hydroxy, and R 3 R 4 N—; R 2 is selected from the group consisting of C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-6 alkyl, C 4-8 cycloalkenyl-C 1-6 alkyl, C 3-6 heterocycloalkyl-C 1-6 alkyl, C 4-8 cycloalkenyl, R 3 R 4 N—, C 3-5 heteroaryl, C 6-10 aryl and C 3-6 heterocycloalkyl, wherein said C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-6 alkyl, C 4-8 cycloalkenyl-C 1-6 alkyl, C 3-6 heterocycloalkyl-C 1-6 alkyl, C 4-8 cycloalkenyl, C 3-5 heteroaryl, C 6-10 aryl or C 3-6 heterocycloalkyl used in defining R 2 is optionally substituted by one or more groups selected from halogen, cyano, nitro, methoxy, ethoxy, methyl, ethyl, hydroxy and R 3 R 4 N—; and R 3 and R 4 and are independently selected from —H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl.