Patent ID: 7456209

Claim:
A compound represented by formula (5) or a pharmaceutically acceptable salt thereof where A 1 is H, or lower alkyl, or A 1 and R 1b together form a ring of 3-5 atoms; R 1a is H; and R 1b is lower alkyl group, or together with A 1 forms a ring of 3 to 5 atoms; Y is an alkyl group, an alkynyl group, a cycloalkyl group of 3 to 7 carbon atoms, optionally substituted versions of these groups, hydroxy substituted versions of these groups, or Y together with Z 1a , Z 1b , or R 10 forms a carbocyclic ring, or a heterocyclic ring containing 1 to 5 heteroatoms, where Y is linked to Z 1a , Z 1b , or R 10 ; Z 1a and Z 1b are independently an H, hydroxy, amino, alkylamino, diakylamino, alkoxy, aryloxy, or heteroaryloxy group; or Z 1a , Z 1b , together with Y or R 10 form a carbocyclic ring, or a heterocyclic ring containing 1 to 5 heteroatoms, where Z 1a or Z 1b , is linked to Y or R 10 ; M is an alkylene group of 1 to 5 carbon atoms; G is a bond, a heteroatom, —(C═O)—; —NR 18 —; —NCOR 18 —; or —NS(O) x R 18 — where x =0, 1, or 2, and R 18 is lower alkyl, optionally-substituted lower alkyl group; and R 10 is anyone of structures (4a), (4b), (4c) or (4d): where X 2 is a nitrogen atom and independently groups R 11 , R′ 11 , R 12 , any of R 13-17 , or any of R 14-17 are H, halogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, hydroxyl, alkoxy, polyalkylether, amino, alkylamino, dialkylamino, alkyloxyalkyl, sulfonate, aryloxy or heteroaryloxy; independently R 11 , R′ 11 , R 12 , any of R 13-17 , or any of R 14-17 are H, optionally-substituted alkyl, aryl, alkenyl, alkynyl, heteroaryl, hydroxyl, alkoxy, polyalkylether, amino, alkylamino, dialkylamino, alkyloxyalkyl, aryloxy, or heteroaryloxy; independently R 11 , R′ 11 , R 12 , any of R 13-17 , or any of R 14-17 are acyl or acetyl groups, carboxylate, sulfonate, sulfone, imine, or oxime groups; or groups R 11 , R′ 11 , R 12 , any of R 13-17 , or any of R 14-17 are contained within a carbocyclic ring, or a heterocyclic ring containing 1 to 5 heteroatoms, and linked to groups at position Y, Z 1a , Z 1b , M, G, R 11 , R′ 11 , R 12 , any of R 13-17 , or any of R 14-17 .