Patent ID: 6841552

Claim:
A compound of the formula: in which R 1 is independently selected from the group consisting of hydrogen; hydroxy; halo; C 1-8 alkyl; C 1-8 alkoxy; substituted C 1-8 alkyl wherein the substituent is halo; substituted C 1-8 alkoxy wherein the substituent is halo; trifluoroalkyl; C 1-8 alkylthio and substituted C 1-8 alkylthio wherein the substituent is selected from halo, trifluoroalkyl and C 1-8 alkoxy; C 3-6 cycloalkyl; C 3-8 cycloalkoxy; nitro; amino; C 1-6 alkylamino; C 1-8 dialkylamino; C 4-8 cycloalkylamino; cyano; carboxy; C 1-5 alkylcarbonyloxy; C 1-5 alkoxycarbonyloxy; formyl; carbamoyl; phenyl; and substituted phenyl wherein the substituent is selected from halo, hydroxyl, nitro, amino and cyano; n is 0-2; B 2 is selected from the group consisting of hydrogen; C 1-5 alkyl; substituted C 1-5 alkyl wherein the substituent is halo; B 2 may have either a cis- or trans-stereochemical orientation with respect to B 1 ; Y is methylene (—CH 2 —) or carbonyl (C═O) L is selected from the group consisting of C 1-8 alkylene; C 2-10 alkenylene; C 2-10 alkynylene; C 3-7 cycloalkylene; C 3-7 cycloalkylC 1-4 alkylene; arylC 1-4 alkylene; (N-methylene)piperidin-4-yl; (N-methylene)piperazin-4-yl; (N-methylene)piperidin-4,4-diyl; R 2 is independently selected from the group consisting of hydrogen; C 1-5 alkyl; substituted C 1-5 alkyl wherein the substituent is halo; B 1 is hydrogen; B 2 may have either a cis- or trans-stereochemical orientation with respect to B 2 ; Z is selected from the group consisting of: phenyl; N-sulfonamido; N-(aryl)sulfonamido; 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl; and 1-aryl-2,3-dihydro-4-oxo-imidazol-5,5-diyl; R 3 is selected from the group consisting of C 1-8 alkyl; substituted C 1-8 alkyl wherein the substituent is selected from alkoxy and halo; cycloalkyl; substituted cycloalkyl wherein the substituent is selected from C 1-8 alkoxy and halo; naphthyl; substituted naphthyl wherein the substituent is selected from halo, nitro, amino and cyano; heteroaryl wherein the heteroaryl group is selected from pyridyl, pyrimidyl, furyl, thienyl and imidazolyl; and substituted heteroaryl wherein the substituent is selected from halo, nitro, amino and cyano; R 4 is independently selected from the group consisting of C 1-8 alkyl; alkoxy; hydroxy; halo; cyano, nitro; amino and alkylamino; substituted C 1-8 alkyl wherein the substituent is halo; m is 0-2; with the following provisions: when L is C 1-8 alkylene; C 2-10 alkenylene; C 2-10 alkynylene; C 37 cycloalkylene; C 3-7 cycloalkyleneC 1-4 alkylene; arylC 1-4 alkylene; (N-methylene)piperidinA-4-yl; then Z is phenyl; N-sulfonamido; N-(aryl)sulfonamido; or 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl; when L is (N-methylene)piperazin-4-yl; then Z is phenyl or aryl; and when L is (N-methylene)piperidin-4,4,-diyl; then Z is 1-aryl-2,3-dihydro-4-oxo-imidazol-5,5-diyl; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.