Patent ID: 8207163

Claim:
A compound of structural Formula (II): or racemic mixtures thereof, diasteromeric mixtures thereof, optical isomers thereof, isotopes thereof, or a pharmaceutically acceptable salt thereof, wherein: X is O, S, NH or NR 7 ; SP is a spacer, wherein the spacer is O, alkyl, substituted alkyl, alkoxy, alkylthio, or -aryl-O-alkyl-; ‘A’ is —O—(CH 2 ) n —, —S—(CH 2 ) n —, —S(O)(O)—(CH 2 ) n —, —NH—(CH 2 ) n —, —CH 2 —O—(CH 2 ) n —, —(CH 2 ) n —O—CH 2 —CH 2 —, —CH 2 —S—(CH 2 ) n —, —(CH 2 ) n —S—CH 2 —CH 2 —, —CH 2 —S(O)(O)—(CH 2 ) n —, —(CH 2 ) n —S(O)(O)—CH 2 —CH 2 —, —O—C(O)—(CH 2 ) n —, —S—C(O)—(CH 2 ) n —, —NH—C(O)—(CH 2 ) n —, —CH 2 —C(O)—O—(CH 2 ) n —, —CH 2 —C(O)—NH—(CH 2 ) n —, —CH 2 —C(O)—S—(CH 2 ) n —, —(CH 2 ) n —C(O)—O—CH 2 —CH 2 —, —(CH 2 ) n —C(O)—NH—CH 2 —CH 2 —, —(CH 2 ) n —C(O)—S—CH 2 —CH 2 —, —CH 2 —O—C(O)—(CH 2 ) n —, —CH 2 —NH—C(O)—(CH 2 ) n —, —CH 2 —S—C(O)—(CH 2 ) n —, —(CH 2 ) n —O—C(O)—CH 2 —CH 2 —, (CH 2 ) n —NH—C(O)—CH 2 —CH 2 —, or —(CH 2 ) n —S—C(O)—CH 2 —CH 2 —; n is an integer between 1 and 7; cyclic ring-‘H’ is ‘B’ is O; R 2 , R 3 , and R 4 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, alkoxy, alkylsulfinyl, alkylsulfonyl, alkylthio, amino, alkylamino, arylalkylamino, dialkylamino, arylalkoxy, cyano, halogen, and hydroxy; R 6 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; R 7 is alkyl or substituted alkyl; optionally one or more hydrogens of R 2 , R 3 , R 4 , R 6 and A are substituted with 2 H (deuterium).