Patent ID: 8772505

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: A is a 9- to 10-membered bicyclic heteroaryl containing one N atom and optionally, one to two additional heteroatoms independently selected from the group consisting of N, O, and S, wherein A is substituted on one ring carbon atom with R 3 , and wherein A is optionally substituted on one to two ring carbon atoms with R 3a and is optionally substituted on one ring nitrogen atom with R 1 ; B is a ring selected from the group consisting of: wherein B is optionally substituted on one or more ring carbon atoms by one to three R 10 ; and wherein when B is then A and D are each bonded to a common ring of B; D is a 9 to 10-membered bicyclic heteroaryl containing one N atom and optionally, one to two additional heteroatoms independently selected from the group consisting of N, O, and S, wherein D is substituted on one ring carbon atom with R 4 , and wherein D is optionally substituted on one two carbon atoms with R 4a and is optionally substituted on one ring nitrogen atom with R 2 ; R 3 and R 4 are independently selected from the group consisting of: wherein R 3 and R 4 are optionally and independently substituted with: (a) one to two fluorine or C 1 -C 3 alkyl; (b) and one to seven 2 H; each occurrence of R 3a and R 4a is independently selected from the group consisting of H, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, halo, and C 1 -C 3 trifluoroalkoxy; R 1 and R 2 are independently H or C 1 -C 3 alkyl; each occurrence of R 5 is independently selected from the group consisting of: (a) —C(O)—(C 1 -C 6 alkyl) optionally substituted by one to eight R 12 groups, wherein R 12 is selected from the group consisting of: (i) C 1 -C 3 alkoxy, (ii) phenyl, optionally substituted by one to four halo, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; (iii) amino, (iv) C 1 -C 3 monoalkylamino, (v) C 1 -C 3 dialkylamino, (vi) —NHC(O)—O—(C 1 -C 6 alkyl), (vii) —N(C 1 -C 3 alkyl)—C(O)—O—(C 1 -C 6 alkyl), (viii) C 1 -C 3 fluoroalkyl, (ix) C 2 -C 6 alkynyl, (x) C 3 -C 7 cycloalkyl, (xi) pyrrolidinyl, (xii) piperidinyl, (xiii) pyranyl; and (xiv) 2 H; (b) wherein x is 1 or 2, and each occurrence of R 6 is independently selected from the group consisting of H, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, and fluoro; and (c) H; each occurrence of R 10 is independently 2 H, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, cyano, and phenyl; and R 10a is H or C 1 -C 6 alkyl.