Patent ID: 7279593

Claim:
A compound according to the general formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is independently selected from: carboxylic acid (—CO 2 H); carboxylic acid ester (—CO 2 R c ); alpha-hydroxy carboxylic acid (—CH(OH)CO 2 H); alpha-amino carboxylic acid (—CH(NH 2 )CO 2 H); phosphonic acid (—PO(OH) 2 ); phosphamic acid (—PO(OH)NH 2 ); sulphonic acid (—SO 2 OH); hydroxamic acid (—CONHOH); oxamic acid (—NHCOCO 2 H); and malonamic acid (—NHCOCH 2 CO 2 H), and bioisosteric equivalents of any thereof; R 2 and R 3 are the same or different and independently selected from: chlorine; bromine; iodine; C 1-4 alkyl or haloalkyl; C 2-4 alkenyl or haloalkenyl; C 2-4 alkynyl or haloalkynyl, or a bioisosteric equivalent of any thereof; R 4 is selected from: halogen; C 1-4 alkyl; C 2-4 alkenyl; and C 2-4 alkynyl, each being optionally substituted with 1, 2 or 3 halogen atoms, which may be the same or different, or a bioisosteric equivalent of any thereof; X is selected from: —CH 2 —CH 2 —; —CH 2 —CH 2 —CH 2 ; —CH═CH—; —CH═CH—CH 2 —; —C≡C—; and —C≡C—CH 2 ; R 5 is selected from C 6-10 aryl; C 1-9 heteroaryl; and C 5-10 cycloalkyl, each being optionally substituted with 1, 2, or 3 groups of R b which may be the same or different; R b is selected from: halogen; —CN; —CO 2 H; —CHO; —NO 2 ; C 1-4 alkyl; C 2-4 aklenyl; C 2-4 alkynyl; C 1-4 alkoxy; C 2-4 alkenoxy; C 2-4 alkynoxy; C 1-4 alkylthio; C 2-4 alkenylthio; C 2-4 alkynylthio; —(CH 2 ) n —OH; —(CH 2 ) n —O(C 1-4 ); —(CH 2 ) n —NH 2 ; —(CH 2 ) n —NH(C 1-4 ); and —(CH 2 ) n —N(C 1-4 ) 2 , or a bioisosteric equivalent of any thereof; R c is selected from C 1-4 alkyl; C 2-4 alkenyl; and C 2-4 alkynyl; n is 1 or 2; and prodrug ester forms thereof.