Patent ID: 7534448

Claim:
A method of treatment or inhibition of undesirable proliferation of cells comprising administering polymeric microparticles or nanoparticles at a site of or adjacent to a region of undesired proliferation, wherein the microparticles or nanoparticles have a diameter of between 50 nm and 1000 microns, wherein the polymer is a hydrophobic polymer and the microparticles or nanoparticles comprise ligands with a hydrophile-lipophile balance of less than 10, wherein the ligands have a first end inserted into the surface of the microparticles or nanoparticles, and a second end facing outwardly from the surface of the microparticles or nanoparticles, wherein the microparticles or nanoparticles comprise an anti-proliferative factor, wherein the anti-proliferative factor is selected from the group consisting of cytotoxic, cytostatic, and anti-angiogenic agents, and wherein the microparticles or nanoparticles are administered in an amount effective to inhibit or decrease cellular proliferation in the region of undesired proliferation.