Patent ID: 8618123

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: X is selected from the group consisting of â€”C(R 1 ) 2 â€”, â€”Oâ€”, â€”Sâ€”, â€”S(O 2 )â€”, â€”NR 1 â€”, and â€”N(C(O)R 1 )â€”; The dotted line ( ) represents an optional bond between Y and Z; Y is selected from the group consisting of N, CH and C, and when Y is N the optional bond is absent, when Y is CH the optional bond is absent, and when Y is C the optional bond is present; Z is selected from the group consisting of: CH, C, and N, provided that both Y and Z are not N, and when Z is N the optional bond is absent, when Z is CH the optional bond is absent, and when Z is C the optional bond is present; Q represents a 5 to 8 membered ring fused to Rings A 1 and Q 1 , wherein Y and Z are as defined above and the remaining Q ring members are â€”CH 2 â€” groups; Q 1 is a 5 to 7 membered ring (including Y and Z) fused to Ring Q, said Q 1 ring comprising at least one heteroatom selected from the group consisting of N, S, S(O), and S(O) 2 , or Q 1 is a 5 membered ring comprising an oxygen atom; or Q 1 is a 5 to 7 membered ring (including Y and Z) fused to Ring Q, said Q 1 ring comprising at least one heteroatom selected from the group consisting of N, S, S(O), and S(O) 2 , or Q 1 is a 5 membered ring comprising an oxygen atom; and said Q 1 ring being substituted with 1 to 3 substituents independently selected from the group consisting of: R 3 substituents; Each R 1 is independently selected from the group consisting of H and alkyl; R 2 is selected from the group consisting of: H, and alkyl; Each R 3 substituent is independently selected from the group consisting of: (1) alkyl, (2) alkoxyalkyl-, (3) hydroxyalkyl, (4) â€”OR 2 , (5) arylalkyl-, (6) â•O, (7) substituted arylalkyl-, (8) alkenyl, (9) heterocycloalkylalkyl-, (10) -alkyl-C(O)OH, (11) -alkyl-NR 5 R 6 , wherein R 5 and R 6 are each independently selected from the group consisting of: H and alkyl, (12) -alkyl-C(O)NR 5 R 6 , wherein R 5 and R 6 are as defined in (11), (13) arylalkenyl-, (14) -alkyl-C(O)OR 7 wherein R 7 is a C 1 to C 6 alkyl group, and (15) substituted arylalkenyl-, wherein said substituted arylalkenyl- is substituted with 1 to 3 substituents independently selected from the group consisting of: â€”OR 5 , â€”NR 5 R 6 , â€”CF 3 , â€”CN, â€”C(O) 2 R 5 , and â€”C(O)NR 5 R 6 , and wherein R 5 and R 6 are as defined in (11); or two R 3 groups bound to the same carbon, taken together with the carbon to which they are bound, form a cycloalkyl ring or form a cycloalkenyl ring; Ar is selected from the group consisting of: (a) unsubstituted aryl, (b) aryl substituted with one or more L 1 groups, (c) unsubstituted heteroaryl, and (d) substituted heteroaryl substituted with one or more L 1 groups; each L 1 is independently selected from the group consisting of: halogen, alkyl, â€”CN, â€”CF 3 , â€”Oâ€”(C 1 -C 6 )alkyl, â€”O-(halo(C 1 -C 6 )alkyl), â€”C(O)â€”Oâ€”(C 1 -C 6 )alkyl, -alkylene-OH, halo(C 1 -C 6 )alkyl, hydroxyalkoxy-, and alkoxyalkoxy-; and n is 0, 1, 2 or 3.