Patent ID: 7534807

Claim:
A method of making a compound of Formula I: wherein: X is NH; R 1 and R 2 are each independently selected from the group consisting of H, alkyl, aryl, alkoxy, halo, mercapto, cyano, hydroxyl, nitro, acyl, alkylthio, alkylamino, acyloxy, and —C(O)NR a R b where R a and R b are each independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl and aryl; R 3 and R 4 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, and arylalky; R 5 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, alkoxy, halo, cyano, nitro, acyl, alkylthio, alkylamino, arylalkylamino, disubstituted amino, acylamino, acyloxy, and —C(O)NR a R b where R a and R b are each independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl and aryl; R 6 and R 7 are each independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, halo, cyano, nitro, acyl, alkoxy, alkylthio, alkylamino, arylalkylamino, disubstituted amino, acylamino, acyloxy, —C(O)NR a R b where R a and R b are each independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl and aryl, —C(O)OR c where R c is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl and aryl, and C(O)OH; and R 8 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, halo, cyano, nitro, acyl, alkoxy, alkylthio, alkylamino, arylalkylamino, disubstituted amino, acylamino, acyloxy, and —C(O)NR a R b where R a and R b are each independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl and aryl; said method comprising condensing a pair of compounds of Formula II: in an organic solvent in the presence of an acid to produce the compound of Formula I, wherein: R is —C(OR d )(OR e )H or —C(O)H, where R d and R e are each independently selected from the group consisting of alkyl, aryl, and alkylaryl, or where R d and R e together form a group —R″— where R″ is an alkylene; X and R 1 to R 7 are as given above; and R 11 and R 12 are each H; or R 11 and R 12 together form a covalent bond.