Patent ID: 7482340

Claim:
A compound of formula (I) or (II): wherein X is —O—,—CH 2 — or —C(O)—; Z is —CHR 12 —or valence bond; Y is —CH 2 —, —C(O)—, CH(OR 13 )—, —O—, —S—; provided that in case Z is a valence bond, Y is not C(O); the dashed line represents an optional double bond in which case Z is —CR 12 — and Y is —CH 2 —, —C(O)— or CH(OR 10 )—(in formula II) or —CH— (in formula I); R 2 and R 3 are independently H, lower alkyl, lower alkoxy, —NO 2 , halogen, —CF 3 , —OH, benzyloxy or a group of formula (IIIa) R 1 is H, CN, halogen, —CONH 2 ,—COOR 15 , —CH 2 NR 15 R 18 , NHC(O)R 5 , NHCH 2 R 5 , NHR 20 , NR 21 R 22 , NHC(NH)NHCH 3 or, in case the compound is of formula (II) wherein the optional double bond exists or in case R 2 or R 3 is benzyloxy or a group of formula (IIIa), R 1 can also be —NO 2 or NR 16 R 17 ; R 4 is H, —NO 2 ,CN, halogen, —CONH 2 ,—COOR 15 , —CH 2 NR 15 R 18 , —NR 16 R 17 , —NHC(O)R 5 or —NHC(NH)NHCH 3 ; R 5 is alkyl substituted with 1-3 substituents selected from the group consisting of halogen, amino and hydroxy, or carboxyalkyl, in which the alkyl portion is optionally substituted with 1-3 substituents selected from the group consisting of halogen, amino and hydroxyl, —CHR 6 NR 7 R 8 or one of the following groups: W is N or CH; Q is CHR 14 , NR 9 , S or O; R 6 is H or lower alkyl; R 7 and R 8 are independently H, acyl, lower alkyl or lower hydroxyalkyl; R 9 is H, lower alkyl or phenyl; R 10 and R 11 are independently H or lower alkyl; R 12 is H or lower alkyl; R 13 is H, alkylsulfonyl or acyl; R 14 is H, —OH, —COOR 15; R 15 is H or lower alkyl; R 16 and R 17 are independently H, acyl, alkylsulfonyl, —C(S)NHR 18 or —C(O)NHR 18 ; R 18 is H or lower alkyl; R 19 is H or —OH; R 20 is a pyridinyl group optionally substituted with a —NO 2 group; R 21 and R 22 are lower alkyl; or a pharmaceutically acceptable salt or ester thereof.