Patent ID: 7718648

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein: R f1 is hydrogen, or R f1 and R f2 together form a bond; R f2 is hydrogen, or R f2 forms a bond with either R f1 or R x ; R x and R y are each independently hydrogen, fluoro, or an optionally substituted C 1-6 aliphatic; or R x and R y , taken together with the carbon atom to which they are attached, form an optionally substituted 3- to 6-membered cycloaliphatic ring; or R x and R f2 together form a bond; one of Q and Z is —N—, and the other is —CH—; G is hydrogen, an optionally substituted aliphatic or Ring B when R f1 is hydrogen; and G is hydrogen, —OR 5 , —N(R 4 ) 2 , —SR 5 , an optionally substituted aliphatic, or Ring B when R f1 and R 2 together form a bond; Ring A is a substituted or unsubstituted 5- or 6-membered aryl, heteroaryl, cycloaliphatic, or heterocyclyl ring; Ring B is a substituted or unsubstituted aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring; Ring C is a substituted or unsubstituted aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring; R a is hydrogen, —C(O)R 1 , —CO 2 R 1 , —SO 2 R 1 , or a C 1-3 aliphatic having 0-2 substituents independently selected from R 3 or R 7 ; R e is hydrogen, —OR 5 , —N(R 4 ) 2 , —SR 5 , —NR 4 C(O)R 5 , —NR 4 C(O)N(R 4 ) 2 , —NR 4 CO 2 R 6 , —N(R 4 )SO 2 R 6 , —N(R 4 )SO 2 N(R 4 ) 2 , or a C 1-3 aliphatic optionally substituted with R 3 or R 7 ; R 1 is C 1-6 aliphatic or an optionally substituted aryl, heteroaryl, or heterocyclyl group; each R 3 independently is selected from the group consisting of -halo, —OH, —O(C 1-3 alkyl), —CN, —N(R 4 ) 2 , —C(O)(C 1-3 alkyl), —CO 2 H, —CO 2 (C 1-3 alkyl), —C(O)NH 2 , and —C(O)NH(C 1-3 alkyl); each R 4 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; or two R 4 on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 5- to 6-membered heteroaryl or 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms selected from N, O, and S; each R 5 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; each R 6 independently is an optionally substituted aliphatic or aryl group; and each R 7 independently is an optionally substituted aryl, heterocyclyl, or heteroaryl group.