Patent ID: 7847930

Claim:
A method for detection of differences between physically measurable properties of a sample and a reference sample, comprising: (i) providing a sample; (ii) providing a reference sample; (iii) providing a two-dimensional reference field; (iv) producing a first two-dimensional pattern from regions of the reference sample and from the reference field, and producing a second two-dimensional pattern from regions of the sample and of the reference field, the first and second patterns being described by a location-dependent and wavelength-dependent pattern function; (v) detecting, for the first pattern, at a freely selectable time, and for the second pattern, at a time by a detector, transmission, reflection or scattering of analytical radiation by the first pattern and the second pattern, respectively, as a function of local coordinates of the first and second patterns, respectively, and of the wavelength of the analytical radiation and thus a first pattern response function, which contains physically separated regions of a reference response function and of a first reference field response function, is determined for the first pattern, a second pattern response function, which contains physically separated regions of a sample response function and of a second reference field response function, is determined for the second pattern, the first and second pattern response functions in each case reproduce intensity of the transmitted, reflected or scattered analytical radiation as a function of the local coordinates of the first and second patterns, respectively, and of the wavelength at different times of the detection, (vi) making a correction to a sample response function by a data processing system such that, by the first and the second reference field response functions, detector-induced location-dependent, time-dependent and wavelength-dependent fluctuations are eliminated from the sample response function, and obtaining a corrected sample response function; and (vii) determining, by the data processing system, a change in the physically measurable property from the corrected sample response function and the reference response function.