Patent ID: 8507538

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt, ester, prodrug, homolog, tautomer, stereoisomer, or hydrate, or solvate thereof: wherein a dashed line signifies that a single bond or a double bond can be present, provided that there are two double bonds and three single bonds in the ring comprising A 1 , A 2 , and A 3 ; A 1 , A 2 , and A 3 each independently is CH or S or N; provided that one of A 1 , A 2 , and A 3 is S; R 1 is di-substituted phenyl or di-substituted pyridinyl where the phenyl and pyridinyl substituents are each independently selected from the group consisting of halo, nitro, cyano, perfluromethyl, fluorinated methyl, and C 1-4 -alkoxy; provided that if R 1 is di-substituted phenyl, such phenyl is para-substituted with C 1-4 -alkoxy; R 2 is wherein a wavy line indicates a point of attachment; X is —NR′R″ or —OR′″; R′ is H, C 1-4 alkyl, n-hydroxy C 1-4 alkyl, —SO 2 —R 3 , or —CO—R 3 ; R″ is H, —SO 2 —R 5 , C 1-4 alkyl optionally substituted with 1 or more R 4 , or a ring moiety optionally substituted with R 6 wherein such ring moiety is piperidinyl, cyclohexyl, morpholinyl, thiazolyl, pyrazolyl, pyrrolidinyl, imidazolyl, or phenyl; R′″ is H, C 1-4 alkyl, or —CO—R 3 or R′ and R″ taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally singly or multiply substituted with substituents independently selected from the group consisting of —OH, oxo, —NH 2 , n-hydroxy-C 1-4 alkyl, —COOH, —(CH 2 ) m —COOH, —(CH 2 ) m —COOR 3 , —N(R 3 R 3 ), and —(CH 2 ) m —CO—N(R 7 R 7 ); each R 3 is independently C 1-4 alkyl or H; each R 4 is independently H, halo, OH, oxo, ═NH, NH 2 , —COOH, F, —NHR 3 , —N(R 7 R 7 ), —SO 2 —R 3 , —SO 2 —N(R 7 R 7 ), —N(R 3 )—SO 2 —R 3 , —COOR 3 , —OCO—R 3 , —CO—N(R 7 R 7 ), —N(R 3 )—COR 3 , C 1-3 alkyl, C 1-3 alkoxy, and a ring moiety optionally substituted with R 6 wherein such ring moiety is piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrazolyl, imidazolyl, benzimidazolyl, azetidinyl, cyclobutinyl, or phenyl; each R 5 is independently R 4 , C 1-4 alkyl, C 3-6 cycloalkyl, or C 1-4 alkyl optionally substituted with 1 or more R 4 ; each R 6 is independently halo, OH, —NH 2 , —NHR 3 , —N(R 3 R 3 ), —COOH, —COOR 3 , —NHCO—R 3 , each R 7 is independently C 1-4 alkyl or H, or two R 7 taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally substituted with —OH, —NH 2 , —N(R 3 R 3 ), n-hydroxy C 1-4 alkyl, —(CH 2 ) m —COOH, or —(CH 2 ) m —COOR 3 ; each m is independently 0, 1, 2, or 3.