Patent ID: 8367112

Claim:
A dispersion of a stable nanoparticulate carvedilol composition comprising: (a) a liquid dispersion medium; (b) particles of carvedilol, a salt thereof, or an optically active isomer thereof having an effective average particle size of less than about 2000 nm dispersed in the liquid dispersion medium; and (c) at least one surface stabilizer adsorbed on the surface of the carvedilol particles, wherein the surface stabilizer is free of intermolecular cross-linkage, and the liquid dispersion medium is water; wherein the carvedilol is in a crystalline phase; wherein at least about 70% of the carvedilol particles, by weight, have a particle size less than the effective average particle size; wherein carvedilol is present in an amount selected from the group consisting of from about 99.5% to about 0.001%, from about 95% to about 0.1%, and from about 90% to about 0.5%, by weight, based on the total combined weight of carvedilol; and wherein at least one surface stabilizer, not including other excipients; is present in an amount selected from the group consisting of from about 0.5% to about 99.999% by weight, from about 5.0% to about 99.9% by weight, and from about 10% to about 99.5% by weight, based on the total combined dry weight of carvedilol and at least one surface stabilizer, not including other excipients.