Patent ID: 8263618

Claim:
A method of treating a mammal having a medical condition ameliorated by treatment with a mu opioid receptor antagonist, wherein the medical condition is opioid-induced bowel dysfunction or post-operative ileus, the method comprising administering to the mammal a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: R 1 is —OR a or —C(O)NR a R b ; R 2 is selected from cyclobutyl, cyclopentyl, cyclohexyl, adamantyl, and phenyl, wherein cyclohexyl and phenyl are each optionally substituted with one or two halo or with C 1-3 alkyl substituted with two or three halo; A is —(CH 2 ) 2 —, or —CH 2 —; G is —(CH 2 ) 2 — or —CH 2 —; R 3 is selected from —C(O)R 4 , —S(O) 2 R c , —S(O) 2 NR a R b , and —C(O)NHR 5 ; R 4 is C 3-6 cycloalkyl or C 1-6 alkyl, wherein C 3-6 cycloalkyl is optionally substituted with one —OR a , and C 1-6 alkyl is optionally substituted with one or two substituents selected from —OR a , —C(O)OR a , —S(O) 2 R 6 , —C(O)NR a R b , —NR a R b , —CN, C 3-6 cycloalkyl, and phenyl, wherein R 6 is C 1-3 alkyl optionally substituted with R 7 , wherein R 7 is —C(O)OR a ; and R 5 is C 1-4 alkyl, benzo[1.3]dioxol, or —(CH 2 ) q -phenyl, wherein q is 0 or 1 and phenyl is optionally substituted with one or two substituents selected from chloro, fluoro, —OH, and —OCF 2 ; or a pharmaceutically-acceptable salt thereof.