Patent ID: 8633220

Claim:
A compound of the structure: wherein: E is C or N; A is —(CH 2 ) m —Ar—(CH 2 ) o — wherein Ar is phenylene or thiophenylene, the sum of m and o is from 1 to 4, and wherein one CH 2 may be substituted with S or O; Q is —CO 2 R 2 , —CH 2 OR 2 , —CONR 2 R 3 , —COR 3 , —SO 2 R 3 or tetrazol-5-yl; R 1 is H, alkoxy, or C 1 -C 20 linear alkyl, branched alkyl, or cycloalkyl, optionally substituted with one or more —OH moieties; R 2 is hydrogen, C 1 -C 6 alkyl, hydroxyethyl, CF 3 , phenyl, or biphenyl; R 3 is hydrogen, C 1 -C 6 linear or branched alkyl, —COR 2 or —SO 2 R 2 ; each R 4 is independently selected from F, Cl, I, or Br; and n is 0 to 6; or a pharmaceutically acceptable salt thereof.