Patent ID: 8840878

Claim:
A compound of Formula (III): or a pharmaceutically acceptable salt thereof; wherein R 1 and R 2 , taken in combination with the N to which they are attached, form a saturated, unsaturated or aromatic heterocyclic ring having 0, 1, or 2 additional ring heteroatorms independently selected from N, O, and S and which heterocyclic ring has from 4 to 7 total ring atoms, said heterocycle having 0, 1, 2, or 3 substituents which are independently selected from C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, hydroxyl, C 1 -C 4 alkoxy, haloC 1 -C 4 alkoxy, amino, mono- and di-C 1-4 alkylamino, aminoC 1 -C 4 alkyl, C 1 -C 4 alkanoylaminoC 1 -C 4 alkyl; R 3 is C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 4 is C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, or saturated 5 or 6 membered heterocyclic ring having 1 or 2 ring heteroatoms independently selected from N, O and S, each of which is substituted with 0-2C 1 -C 4 alkyl groups; J is a bond or a divalent residue of the formula: R 5 is C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, or saturated 5 or 6 membered heterocyclic ring having 1 or 2 ring heteroatoms independently selected from N, O and S, each of which is substituted with 0-2C 1 -C 4 alkyl groups; R 6 is hydrogen or C 1 -C 4 alkyl; E is a bond, CH 2 , C(O), S(O) 2 , C(R 9 ) 2 C(O), or C(O)C(R 9 ) 2 , R 9 is independently selected at each occurrence from hydrogen and C 1 -C 4 alkyl; X is absent or selected from NR 11a or oxygen; i and k are independently selected integers selected from the group consisting of 0, 1, 2, 3 and 4; j is an integer selected from the group consisting of 1, 2, 3 and 4, wherein the sum of i+j+k is less than or equal to 5 and greater than or equal to 2 when X is absent and the sum of i+j+k is less than or equal to 4 and greater than or equal to 1 when X is oxygen; R 11 represents zero to three residues each independently selected at each occurrence from the group consisting of halogen, hydroxy, amino, C 1-4 alkyl, C 3-6 cycloalkyl, C 1-4 alkoxy, mono- and di-C 1-4 alkylamino, hydroxyC 1-4 alkyl, and C 1-4 alkoxyC 1-4 alkyl; and R 11a is independently selected at each occurrence from the group consisting of hydrogen, C 1-4 alkyl, haloC 1-4 alkyl, C 3-6 cycloalkyl, hydroxyC 1-4 alkyl, and C 1-4 alkoxyC 1-4 alkyl.