Patent ID: 7863286

Claim:
A compound according to structural formula (I): or a salt, or N-oxide thereof, that is enriched in the corresponding diastereomer of structural formula (Ia): wherein: each R 1 is independently selected from the group consisting of hydrogen, lower alkyl, â€”(CH 2 ) n â€”OH, â€”OR a , â€”O(CH 2 ) n â€”R a , â€”O(CH 2 ) n â€”R b , â€”C(O)OR a , halo, â€”CF 3 and â€”OCF 3 ; each R 2 is independently selected from the group consisting of hydrogen, lower alkyl, â€”OR a , â€”O(CH 2 ) n â€”R a , â€”O(CH 2 ) n â€”R b , â€”NHC(O)R a , halo, â€”CF 3 , â€”OCF 3 , each R 3 is independently selected from the group consisting of hydrogen, lower alkyl, â€”(CH 2 ) n â€”OH, â€”OR a , â€”O(CH 2 ) n â€”R a , â€”O(CH 2 ) n â€”R b , halo, â€”CF 3 , â€”OCF 3 , each R 4 is independently selected from the group consisting of hydrogen, lower alkyl, arylalkyl, â€”OR a , â€”NR c R c , â€”C(O)R a , â€”C(O)OR a and â€”C(O)NR c R c ; R 5 is hydrogen, halo, fluoro, â€”CN, â€”NO 2 , CO 2 R a , or â€”CF 3 ; each n is independently an integer from 1 to 3; each R a is independently selected from the group consisting of hydrogen, lower alkyl and lower cycloalkyl; each R b is independently selected from the group consisting of â€”OR a , â€”CF 3 , â€”OCF 3 , â€”NR c R c , â€”C(O)R a , â€”C(O)OR a , â€”C(O)NR c R c and â€”C(O)NR a R d ; each R c is independently selected from the group consisting of hydrogen and lower alkyl, or, alternatively, two R c substituents may be taken together with the nitrogen atom to which they are bonded to form a 5-7 membered saturated ring which optionally includes 1-2 additional heteroatomic groups selected from O, NR a , NR a â€”C(O)R a , NR a â€”C(O)OR a and NR a â€”C(O)NR a ; and each R d is independently lower mono-hydroxyalkyl or lower di-hydroxyalkyl.