Patent ID: 7429613

Claim:
A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3hydroxyl-1-pentanoic acid 7 comprising: (a) reacting an aldehyde 1 with a chiral alkoxy substituted acetate and a chelating co-solvent; (b) hydrolysis of (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]3-hydroxy-1-pentanoic acid, chiral alkoxy ester using a base in a solvent to form a carboxylate 7 (c) treating the acid with a chiral base to form a salt and purifying the salt.