Patent ID: 8314137

Claim:
A compound of the formula: wherein: R 1 , R 3 , R 4 , R 5 and R 6 are each independently: hydrogen, hydroxy, amino, cyano, or alkyl (C≦18) , alkenyl (C≦18) , alkynyl (C≦18) ; aryl (C≦18) , aralkyl (C≦18) , heteroaryl (C≦18) , heteroaralkyl (C≦18) , acyl (C≦18) , alkoxy (C≦18) , alkenyloxy (C≦18) , alkynyloxy (C≦18) , aryloxy (C≦18) , aralkoxy (C≦18) , heteroaryloxy (C≦18) , heteroaralkoxy (C≦18) , acyloxy (C≦18) , alkyl-amino (C≦18) , dialkylamino (C≦18) , alkoxyamino (C≦18) , alkenyl-amino (C≦18) , alkynylamino (C≦18) , arylamino (C≦18) , aralkylamino (C≦18) , heteroarylamino (C≦18) , heteroaralkylamino (C≦18) , alkylsulfonylamino (C≦18) , amido (C≦18) , alkylideneamino (C≦18) ; aralkylideneamino (C≦18) ; or a substituted version of any of these groups; R 1 and R 3 are taken together and are alkanediyl (C≦18) , alkenediyl (C≦18) , arenediyl (C≦18) , alkoxydiyl (C≦18) , alkenyloxydiyl (C≦18) , alkylaminodiyl (C≦18) , alkenylaminodiyl (C≦18) , alkenylaminooxydiyl (C≦18) , alkenyl-aminothiodiyl (C≦18) , with R 2 , R 4 , R 5 and R 6 as defined above; or R 3 and R 5 are taken together and are alkanediyl (C≦18) , alkenediyl (C≦18) , arenediyl (C≦18) , alkoxydiyl (C≦18) , alkenyloxydiyl (C≦18) , alkylaminodiyl (C≦18) , alkenylaminodiyl (C≦18) , alkenylaminooxydiyl (C≦18) , alkenyl-aminothiodiyl (C≦18) , with R 1 , R 2 , R 4 and R 6 as defined above; provided that: R 4 is absent when the atom to which it is bound forms part of a double bond; R 6 is absent when the atom to which it is bound forms part of a double bond; neither R 1 nor R 2 is hydrogen; and R 1 and R 2 are not both methyl; and R 2 is cyano, alkynyl (C≦8) , substituted alkynyl (C≦8) , or —C≡C—R 9 wherein R 9 is: hydrogen or cyano; or alkyl (C≦6) , aryl (C≦6) , acyl (C≦6) , alkylsilyl (C≦6) or a substituted version of any of these groups; or a pharmaceutically acceptable salt or tautomer of the formula.