Patent ID: 8791279

Claim:
A process for preparing a taxoid of general formula (X), comprising the steps of: (a) reacting a protected baccatin III derivative (B) with a β-lactam of the general formula (C) in the presence of one or more Lewis acids ML and a first base agent to obtain a protected taxoid of general formula (X 0 ) having one or more silyl ether protecting groups; and (b) removing the silyl ether protecting groups to obtain the taxoid of general formula (X); wherein: M is selected from the group consisting of cations of Li, Na, K, Rb, Cs, Be, Mg, Ca, Sr, Ba, Cu, Ag, Au, Zn, Cd, Hg, Fe, Co, Ni, Ru, Rh, Pd, Os, Ir, Pt, Sc, Y, Ti, V, Nb, Co, B, Al, In, Sn, Ce, and any combination thereof; L is a counter ion to M; R′ 1 is alkoxy, —O—C(═O)—R 10 , or —O—Si(R 11 )(R 12 )(R 13 ); R′ 2 is alkoxy, or —O—Si(R 21 )(R 22 )(R 23 ), or R′ 2 is H when R′ 3 is taken together with C7 to form a cycloalkyl ring; R′ 3 is alkyl, or taken together with C7 to form a cycloalkyl ring; R′ 5 is —O—Si(R 51 )(R 52 )(R 53 ); R 1 is hydroxyl, alkoxy, or —O—C(═O)—R 10 ; R 2 is hydroxyl, alkoxy, or R 2 is H when R 3 is taken together with C7 to form a cycloalkyl ring; R 3 is alkyl, or taken together with C7 to form a cycloalkyl ring; R 4 is alkoxy or phenyl; R 10 is alkyl; and R 11 , R 12 , R 13 , R 21 , R 22 , R 23 , R 51 , R 52 , and R 53 are independently alkyl.