Patent ID: 8796312

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ar 1 is Ar 1 is optionally substituted with w occurrences of —W—R W ; wherein W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by —CO—, —O—, —S—, —SO 2 —, or —NR′—; R′ is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; and R W is independently H, halo, CN, NO 2 , NH 2 , CF 3 , OCF 3 , OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, or heteroaryl, wherein, when substituted, R W is substituted with up to two R 2 ; R 2 is halo, CN, NO 2 , CF 3 , OCF 3 , OH, —(C1-C6)alkylidene-OH, —(C1-C6)alkylidene-N(R) 2 , OC(O)R, OC(O)N(R) 2 , SR, S(O)R, SO 2 R, SO 2 N(R) 2 , SO 3 R, C(O)R, CO 2 R, C(O)N(R) 2 , N(R) 2 , NRC(O)R, NRCO 2 R, NRC(O)N(R) 2 , NRSO 2 R, B(OR) 2 , or NRSO 2 N(R) 2 ; R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; R N is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; A is an optionally substituted 3-7 membered monocyclic ring; B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl; J is selected from the group consisting of CH 2 , CF 2 , C(CH 3 ) 2 , C(O), C(Phenyl) 2 , B(OH), and CH(OEt); and w is independently an integer from 0 to 5 inclusive.