Patent ID: 7632663

Claim:
A microorganism transformed with a nucleotide sequence encoding dihydroxy acid dehydratase (ilvD), nucleotide sequences encoding acetohydroxy acid synthase and isomeroreductase (ilvBNC) or both ilvD and ilvBNC, in which microorganism the activity of one or more enzymes that are specifically involved in the synthesis of D-pantothenate is reduced or eliminated, wherein said one or more enzymes are selected from the group consisting of ketopantoate hydroxymethyl transferase (panB), pantothenate ligase (panC), ketopantoic acid reductase (panE) and aspartate decarboxylase (panD) and said activity of said one or more enzymes is reduced or eliminated as a result of deletion of all or a part of the nucleotide sequence encoding said enzyme in said microorganism and wherein said microorganism is a Corynebacterium species and said nucleotide sequence encoding ilvD comprises the portion of SEQ ID NO: 1 encoding ilvD.