Patent ID: 8148599

Claim:
A method of predicting a behavior of a single drug or a plurality of drugs in a human, as part of a drug screening or evaluation process, comprising administering the single drug or the plurality of drugs to a transgenic mouse comprising in its genome a homozygous disruption of an endogenous mouse multidrug-resistance-associated protein (MRP) gene and a stably integrated nucleotide sequence that encodes a human MRP polypeptide operably linked to a promoter selected from the group consisting of an endogenous mouse MRP gene promoter, and the human MRP gene promoter, wherein the human MRP polypeptide is a homologue of the endogenous mouse MRP, wherein the expression of the endogenous MRP gene is abrogated, and wherein expression of the nucleotide sequence that encodes the human MRP polypeptide provides a mouse that predicts behavior of a drug in a human, and conducting analytical tests to determine the behavior of the single drug or the plurality of drugs in the transgenic mouse, the results of which have a higher correlation to the behavior of the drug in the human than the results obtained from a wild type mouse.