Patent ID: 8609632

Claim:
A low molecular weight heparin (LMWH) composition comprising: oligosaccharide chains that have the following structure: and oligosaccharide chains that have the following structure: wherein R is H or SO 3 Na; R 1 is SO 3 Na or COCH 3 ; and n=2-50; wherein the composition has the following properties: (a) an average value for n of 9-16, (b) 5 to 15% ΔUH NAc,6S GH NS,3S,6S as measured by mole %, (c) weight average molecular weight of 5500 to 8500 Da, (d) an anti-Xa activity of 170 to 330 IU/mg, (e) an anti-Xa to anti-IIa ratio of 2:1 to 1:1, (f) an anti-IIa activity of 130 to 190 IU/mg, (g) a polydispersity in the range from 1.1 to 1.6, and (h) the ratio of (e) is constant over a period of about 30 to 120 minutes after administration to a subject.