Patent ID: 8288569

Claim:
A process for the asymmetric alkylation of a carbonyl group in a compound (compound K) containing a carbonyl group and an anchor group that reacts with a boric or boronic acid derivative, comprising the steps of: a) admixing the compound K with a boric or boronic acid derivative; b) adding a chiral auxiliary (compound A); and c) adding an organometallic compound, wherein the steps a), b) and c) are conducted in any order or simultaneously wherein the boric or boronic acid derivative is a compound of formula VI, wherein R 1 is hydrogen, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 6-10 -aryl, C 7-16 alkaryl, a 4-10 membered heterocyclic residue, C 1-10 -alkoxy, C 1-10 -alkylamino, C 1-10 -alkylthio, hydroxy, or cyano; and wherein R 2 is halogen, hydroxy, C 1-10 -alkoxy, C 6-10 -aryloxy, C 1-10 -dialkylamino, or a 4-10 membered heterocyclic residue connected by a S, N, or O atom to the boron atom; and wherein R 3 is halogen, amino, hydroxy, C 1-10 -alkoxy, C 6-10 -aryloxy, C 1-10 -dialkylamino, or a 4-10 membered heterocyclic residue connected by a S, N, or O atom to the boron atom; or wherein R 2 and R 3 are connected to each other to form a 5-10 membered cyclic structure including the boron atom to which R 2 and R 3 are connected, wherein the cyclic structure may contain one or two additional boron, and/or oxygen, and for nitrogen atoms.