Patent ID: 8192957

Claim:
An insulin analogue comprising a single chain polypeptide of formula I, B-C-A (I) wherein B comprises a polypeptide having the sequence: (SEQ. ID. NO. 33) FVNQHLCGSX 2 LVEALYLVCGERGFFYTX 3 X 4 T where X 2 is D or H, X 3 is P, D or K, and X 4 is K or P, wherein C is a polypeptide selected from the group consisting of a polypeptide having the sequence GGGPRR (SEQ ID NO: 19) and a polypeptide having the sequence GGPRR (SEQ ID NO: 20), and wherein A comprises a polypeptide having the sequence: GIVEQCCX 1 SICSLYQLENYCN, (SEQ. ID. NO. 32) where X 1 is T or H.