Patent ID: 7867480

Claim:
A transdermal antigenic composition, comprising at least 4 components, which are: (a) a transdermal carrier comprising a penetrant suspended or dispersed in an aqueous solvent, the penetrant being in the form of a minute fluid droplet surrounded by a coating of one or more layers of at least 2 substances that differ by at least a factor of 10 in solubility, the substances forming homoaggregates of one substance and/or heteroaggregates of the at least 2 substances, the average diameter of homoaggregates of the more soluble substance, or the average diameter of the heteroaggregates of the at least 2 substances, being smaller than the average diameter of homoaggregates of the less soluble substance, and/or the more soluble substance solubilizing the droplet and the content of the more soluble substance being up to 99 mol-% of the concentration required to solubilize the droplet or corresponding to up to 99 mol-% of the saturating concentration in an unsolubilized droplet, whichever is higher, and/or wherein the elastic deformation energy of the droplet surrounded by the coating is at least 5 times lower than the elastic deformation energy of red blood cells or of a phospholipid bilayer having fluid aliphatic chains; (b) a compound which specifically has or induces cytokine or anti-cytokine activity; (c) an antigen or mixture of different antigens and/or an allergen or mixture of different allergens; and (d) a chemical irritant.