Patent ID: 7939528

Claim:
A compound of Formula 1 wherein R 1 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-10 cycloalkyl, arylalkyl, heterocyclyl, heterocycloalkyl, heteroarylalkyl, cycloalkenyl, C 2-12 fluoroalkyl, C 3-10 alkoxy, and heteroalkyl, with the proviso that the carbon atoms that are bonded to the nitrogen are not aromatic or carbonyl; R 2 is selected from the group consisting of C 3-12 alkyl, C 3-10 cycloalkyl, arylalkyl, heterocyclyl, heterocycloalkyl, heteroarylalkyl, cycloalkenyl, C 3-12 fluoroalkyl, C 3-10 alkoxy, and heteroalkyl, with the proviso that the carbon atoms that are bonded to the nitrogen are not aromatic or carbonyl; R 1 and R 2 may optionally be joined to form a ring; A is attached in the meta or para position with respect to the diarylether linker and is a C 1-3 alkylene; R 3 and R 4 are each independently selected from the group consisting of —H, —F, —Cl, —Br, —OH, —OC 1-3 alkyl, —C 1-3 fluoroalkyl, and —C 1-3 alkyl; X, Y, and Z are each independently selected from the group consisting of —N, —NH, —CH, —O, —S, —NR 5 , and —CR 6 , wherein R 5 and R 6 are each independently a C 1-6 alkyl or a fluoroalkyl; and a pharmaceutically acceptable salt thereof.