Patent ID: 8772286

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein A is CH or N; Y is a bond, or —C(O)NH—; X is a bond, —CH 2 —, —CH 2 CH 2 —; V is —CH 2 —, O, C(O), —CHF—, or —CF 2 —, with the proviso that if V is O, X is —CH 2 CH 2 — and that if V is C(O), X is —CH 2 ; W is a bond or —CH 2 —; R1 is hydrogen or F; R2 is a (1-12C)heteroaryl or (6-10C)aryl both optionally substituted with one or more groups independently selected from R4; R3 is a hydrogen; (3-6C)cycloalkyl; (1-6C)alkyl, —(CH 2 ) m OR5; —(CH 2 ) m NR5R6; or —C(O)CH 2 NR5R6; R4 is taken from halogen; OH; SH; nitrile, nitro, NH 2 ; (3-6C)cycloalkyl, (3-6C)cycloalkoxy, (1-6C)alkoxy or (1-6C)alkyl, all optionally substituted with one or more halogen; phenoxy; —O(CH 2 ) m OR5, —O(CH 2 ) m NR7R8, —OC(O)R7 with the proviso that R7 is not hydrogen, —O(1-12C)heteroaryl), —S(1-6C)alkyl); —S(3-6C)cycloalkyl)-; NR7R8; —NR9(CH 2 ) m OR7, —NR9(CH 2 ) m NR7R8; (1-6C)alkylcarbonyl; (3-6C)cycloalkylcarbonyl; —C(O)NR7R8; —C(O)NR9(CH 2 ) m NR7R8, —C(O)NR9(CH 2 ) m OR7, —C(O)OR7, —SO 2 (1-6C)alkyl), —SO 2 (3-6C)cycloalkyl); —O(1-6C)alkyl)O— where the oxygens are attached to the (1-12C)heteroaryl or (6-10C)aryl ring on two neighboring carbons; phenyl or (1-12C)heteroaryl; R5 is hydrogen (3-6C)cycloalkyl; or (1-6C)alkyl; R6 is hydrogen; (3-6C)cycloalkyl; (1-6C)alkyl; or (1-6C)alkylcarbonyl; R7 is hydrogen, (1-6C)alkyl or (3-6C)cycloalkyl; R8 is hydrogen; (3-6C)cycloalkyl; (1-6C)alkyl; or (1-6C)alkylcarbonyl; or R7 and R8 together with the nitrogen to which they are bonded in NR7R8 can form a 5-7-membered at least one nitrogen containing (4-6C)heterocyclyl ring which optionally contains one additional heteroatom selected from N, O or S; R9 is hydrogen; (1-6C)alkyl or (3-6)cycloalkyl; and m is 2 or 3.