Patent ID: 8629257

Claim:
An isolated nucleic acid encoding an amino acid sequence of at least one variable domain of a binding protein, wherein said at least one variable domain comprises CDR-H1, CDR-H2, and CDR-H3 amino acid sequences independently selected from the group consisting of: CDR-H1 CDR-H2 residues 31-37 of SEQ ID NO: 35 residues 52-67 of SEQ ID NO: 35 residues 31-37 of SEQ ID NO: 37 residues 52-67 of SEQ ID NO: 37 residues 31-35 of SEQ ID NO: 39 residues 50-66 of SEQ ID NO: 39 residues 31-35 of SEQ ID NO: 41 residues 50-66 of SEQ ID NO: 41 residues 31-35 of SEQ ID NO: 43 residues 50-66 of SEQ ID NO: 43 residues 31-35 of SEQ ID NO: 45 residues 50-66 of SEQ ID NO: 45 residues 31-35 of SEQ ID NO: 47 residues 50-66 of SEQ ID NO: 47 residues 31-35 of SEQ ID NO: 49 residues 50-66 of SEQ ID NO: 49 residues 31-37 of SEQ ID NO: 51 residues 52-67 of SEQ ID NO: 51 residues 31-35 of SEQ ID NO: 53 residues 47-66 of SEQ ID NO: 53 CDR-H3 residues 100-108 of SEQ ID NO: 35 residues.100-109 of SEQ ID NO: 37 residues 99-106 of SEQ ID NO: 39 residues 99-106 of SEQ ID NO: 41 residues 99-106 of SEQ ID NO: 43 residues 99-101 of SEQ ID NO: 45 residues 99-106 of SEQ ID NO: 47 residues 99-111 of SEQ ID NO: 49 residues 100-109 of SEQ ID NO: 51 residues 99-107 of SEQ ID NO: 53.