Patent ID: 7166572

Claim:
A compound selected from the group consisting of a cyclohexapeptide compound of the formula (I), wherein, R′ is selected from the group consisting of C 9 –C 20 alkyl; C 9 –C 20 alkenyl; C 9 –C 20 alkoxyphenyl, phenyl, biphenyl, terphenyl, and naphthyl; C 1 –C 12 alkylphenyl, C 8 –C 12 alkenylphenyl, C 1 –C 12 alkoxyphenyl; linoleoyl; palmitoyl; 12-methylmyristoyl; 10,12-dimethylmyristoyl; and COC 6 H 4 (p)OC 8 H 17 , R 1 is selected from the group consisting of —CN; —CH 2 NH 2 ; —N 3 ; aryl; substituted aryl, imidazolyl; morpholinoethylamino; —OR, wherein R is C 1 –C 12 alkyl, substituted alkyl of (CH 2 ) n —X, where n is 1–5 and X is selected from the group consisting of OH, aryl, Cl, Br, I, COOY and CN, wherein Y is selected from the group consisting of C 1 –C 6 alkyl, C 2 –C 12 alkenyl, aryl, fused aryl, substituted aryl, a heterocyclic containing 1–3 heteroatoms, mono or di-substituted aminoalkyl and a hydroxy protecting group; R 3 is selected from the group consisting of —OH; —CN; —CH 2 NH 2 ; —N 3 ; aryl; substituted aryl; heterocyclyl and substituted heterocyclyl with 1–3 of heteroatoms; aminoalkylamino; mono or di-substituted linear or cyclic aminoalkylamino; imidazolyl; —OR, wherein R C 1 –C 12 alkyl; substituted alkyl of (CH 2 ) n —X, where n is 1–5 and X is selected from the group consisting of OH, aryl, Cl, Br, I, COOY, CN, NH 2 and heterocyclic, wherein Y is selected from the group consisting of C 1 –C 6 alkyl, C 2 –C 12 alkenyl, aryl, fused aryl, substituted aryl, a heterocyclic containing 1–3 heteroatoms, mono or di-substituted aminoalkyl, and a hydroxy protecting group; R 2 and R 4 are independently —H or —OH; R 5 is —H or —CH 3 ; R 6 is selected from the group consisting of —H, —CH 3 and —CH 2 CONH 2 ; R 7 is selected from the group consisting of —H, —CH 3 and —OH; R 8 and R 9 are independently —H or —CH 2 -Sec.amine in which the sec.amine is attached to —CH 2 through its N linkage; with the proviso that both R 8 and R 9 are not simultaneously hydrogen and wherein the secondary amine is selected from the group consisting of piperidine, pyrrolidine, 4-methylpiperidine, morpholine, dimethylamine, diisopropylamine, 4-piperidino-piperidine, piperazine, 1-methylpiperazine, 1-(2-fluorophenyl)piperazine, 1-(2-chlorophenyl)piperazine, 1-(2-pyrimidyl)piperazine, 1-(4-fluorophenyl)piperazine, N-(α,α,α-trifluoro-m-tolyl)piperazine, 1-phenylpiperazine, 1-benzylpiperazine, 1-(2-pyridyl)piperazine, 1-(4-pyridyl)piperazine, 1-(4-methylphenyl)piperazine, 1-(2,6-dimethylphenyl)piperazine, 1-(1-phenylethyl)piperazine, dibenzylamine, N-(tertbutyl)benzylamine and N-(isopropyl)-benzylamine; and its non-toxic pharmaceutically acceptable salts.