Patent ID: 7799933

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein: X is —NHC(O)— or —C(O)NH—; Y is —C(R 4 R 5 )C(R 6 R 7 )— or —CR 4 ═CR 6 —; R 1 is aryl or heteroaryl, which aryl or heteroaryl is substituted with —C(R 12 R 13 )[C(R 14 R 15 )] n C(O)OR 16 , and which aryl or heteroaryl in addition is optionally substituted with 1 to 2 substitutents independently selected from the group consisting of lower-alkyl, hydroxy, halogen, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy; R 2 is hydrogen, lower-alkyl, hydroxy, halogen, lower-alkoxy, fluoro-lower-alkyl, or fluoro-lower-alkoxy; R 3 is aryl which is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, hydroxy, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, lower-alkyl-C(O), lower-alkyl-C(O)—NH, lower-alkyl-C(O)—N(lower-alkyl), lower-alkyl-S(O) 2 , NH 2 —S(O) 2 , N(H,lower-alkyl)-S(O) 2 , N(lower-alkyl) 2 -S(O) 2 , NH 2 —C(O), N(H,lower-alkyl)-C(O), N(lower-alkyl) 2 -C(O) and lower-alkoxy-C(O), wherein lower-alkyl is optionally substituted with hydroxy, lower-alkoxy, NH 2 , N(H,lower-alkyl), or N(lower-alkyl) 2 ; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 independently from each other are selected from the group consisting of hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, hydroxyl, and hydroxy-lower-alkyl; R 12 , R 13 , R 14 and R 15 independently from each other are selected from the group consisting of hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy, hydroxy, and hydroxy-lower-alkyl; or alternatively R 13 is H and R 12 is —(CH 2 ) 1-3 — and forms a bridge to the aryl or heteroaryl, to which the —C(R 12 R 13 )[C(R 14 R 15 )] n C(O)OR 16 is bound; R 16 is hydrogen or lower-alkyl; and n is 0 or 1.