Patent ID: 7935694

Claim:
A method for treating colon cancer in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein: Ring A is an optionally substituted 5- or 6-membered aryl or heteroaryl ring; G 1 is C═O, C═S, or S(═O) 2 ; Y 1 is N or CH and Y 2 is N or CR e , provided that at least one of Y 1 and Y 2 is N; R a is hydrogen, —C(O)R 5a , C(O)N(R 4a ) 2 , —CO 2 R 6a , —SO 2 R 6a , —SO 2 N(R 4 ) 2 , an optionally substituted C 1-10 aliphatic, or an optionally substituted aryl, heteroaryl, or heterocyclyl ring; R b is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; R c is hydrogen, fluoro, —OR 5 , —N(R 4 ) 2 , or an optionally substituted C 1-4 aliphatic; R d is hydrogen, fluoro, C 1-4 -aliphatic or C 1-4 fluoroaliphatic; or R c and R d , taken together with the carbon atom to which they are attached, form an optionally substituted 3- to 6-membered carbocyclic ring; R e is hydrogen, halo, —NO 2 , —CN, —C(R 5 )═C(R 5 ) 2 , —C≡C—R 5 , —C(R 5 )═C(R 5 )(R 10 ), —C≡C—R 10 , —OR 5 , —N(R 4 ) 2 , —NR 4 C(O)R 5 , —NR 4 C(O)N(R 4 ) 2 , —NR 4 CO 2 R 6 , —CO 2 R 5 , —C(O)R 5 , —C(O)N(R 4 ) 2 , —N(R 4 )SO 2 R 6 , —N(R 4 )SO 2 N(R 4 ) 2 , or an optionally substituted C 1-4 aliphatic; each R 4 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; or two R 4 on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen, atom, 0-2 ring heteroatoms selected from N, O, and S; each R 4a independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; or two R 4a on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms selected from N, O, and S; each R 5 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; each R 5a independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; each R 6 independently is an optionally substituted aliphatic or aryl group; each R 6a independently is an optionally substituted aliphatic or aryl group; and R 10 is —CO 2 R 5 or —C(O)N(R 4 ) 2 .