Patent ID: 8436023

Claim:
A compound of Formula (I) wherein: X is O or NR 3 ; wherein R 3 is: H, C (1-6) alkyl, CH 2 CF 3 , C (1-6) alkylOH, C (2-6) alkenyl, CH 2 OC (2-6) alkenyl, CH 2 OC (1-6) alkyl, C(O)C (1-6) alkyl, CONH 2 , CONHC (1-6) alkyl, SONH 2 , CH 2 Ph, CH 2 heteroaryl, CH 2 heterocyclyl, CH 2 cycloalkyl, C (3-6) cycloalkyl, or SO 2 C (1-2) alkyl; wherein said heteroaryl, heterocyclyl, or cycloalkyl may be optionally substituted with up to three substituents selected from the group consisting of: F, OCH 3 , CH 3 , and OH; Y 1 and Y 2 are CH or N, provided that both Y 1 and Y 2 are not N; Z is O, CH 2 , S, S(O), SO 2 , or a direct bond; wherein R a and R b are independently selected from the group consisting of: H, OH, F, CH 3 , CF 3 , OCF 3 , and OCH 3 ; R 1 is pyridyl, pyridyl-N-oxide, pyrimidyl, pyrazolyl, indolyl, thiazolyl, benzo[1,3]dioxol-5-yl, pyrazolyl, oxazolyl, isoxazolyl, imidazolyl, phenyl, thiazolyl, isothiazolyl, 3-H-thiazol-2-onyl, benzooxazolyl, furyl, [1,2,4]oxadiazolyl, [1,3,4]thiadiazolyl, C (4-7) cycloalkyl, C (1-6) alkyl, C (1-4) alkylOH, CH 2 OC (3-6) alkenyl, CH 2 OC (1-4) alkyl, CH 2 C(O)NH 2 , CO 2 C (1-4) alkyl, —CN, C(O)NH 2 , C(O)NHCH 2 CH 2 OH, OTBS, OH, OC (1-4) alkyl, OC (3-6) alkenyl, NH 2 , NHBOC, or pyridonyl; wherein said pyridyl, pyridyl-N-oxide, pyrimidyl, pyrazolyl, indolyl, thiazolyl, benzo[1,3]dioxol-5-yl, pyrazolyl, oxazolyl, isoxazolyl, imidazolyl, phenyl, thiazolyl, isothiazolyl, 3-H-thiazol-2-onyl, benzooxazolyl, furyl, [1,2,4]oxadiazolyl, [1,3,4]thiadiazolyl, C (4-7) cycloalkyl, C (1-6) alkyl, or pyridonyl, may be optionally substituted with one or two substituents, independently selected from the group consisting of: CH 2 C(O)NH 2 , C (1-4) alkoxy, OC (3-6) cycloalkyl, OCH 2 CF 3 , OCH 2 Ph, F, CN, Cl, OCF 3 , CF 3 , CH 2 CN, C (1-4) alkyl, CH 2 CF 3 , N(C (1-4) alkyl) 2 , C (1-4) alkylOH, Si(CH 3 ) 3 , —C≡CH, SCH 3 , S(O)CH 3 , SO 2 CH 3 , pyrrolidinyl, OH, NH 2 , NHCN, CO 2 H, CONH 2 , NHCO 2 C (1-4) alkyl, N(SO 2 CH 3 ) 2 , NHSO 2 CH 3 , NHC(O)CF 3 , NHC (1-4) alkyl, NHCO 2 H, NHCO 2 C (1-4) alkyl, NHCOC (1-4) alkyl, NHCONH 2 , NHCONHC (1-4) alkyl, and Br; R 2 is F, NH 2 , H, or OH; and tautomers, and pharmaceutically acceptable salts thereof.