Patent ID: 8034959

Claim:
An antibody-drug conjugate comprising the structure: wherein A is a member selected from substituted or unsubstituted phenyl and substituted or unsubstituted pyrrole; Z is a member selected from O, S and NR 23 ; X is a member selected from O, S and NR 23 , wherein R 23 is a member selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and acyl; R 11 is a pro-drug substituent that is labile under physiological conditions to release R 11 ; R 4 and R 5 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, halogen, NO2, NR 15 R 16 , NC(O)R 15 , OC(O)NR 15 R 16 , OC(O)OR 15 , C(O)R 15 , SR 15 , and OR 15 , wherein R 15 and R 16 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl and substituted or unsubstituted peptidyl, or R 15 and R 16 together with the nitrogen atom to which they are attached are joined to form a substituted or unsubstituted heterocycloalkyl ring system having from 4 to 6 members; and R 7 is CH 2 —X 1 , wherein X 1 is a leaving group; and wherein one of R 4 , R 5 , R 15 or R 16 comprises a cleavable linker and an antibody, or a pharmaceutically acceptable salt thereof, wherein the cleavable linker comprises wherein L 3 is a linker, attached to the antibody, which is selected from substituted or unsubstituted C 1-20 alkyl and substituted or unsubstituted C 1-20 heteroalkyl groups; AA 1 , AA c and AA c+1 are members independently selected from natural and unnatural a-amino acids; L 4 is a linker selected from substituted or unsubstituted C 1-20 alkyl, substituted or unsubstituted C 1-20 heteroalkyl groups, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted cycloalkyl; p and t are integers independently selected from 0 and 1; and c is an integer from 0 to 20.