Patent ID: 8135202

Claim:
A method for training a classifier for use in automatic filtering of unlabeled nuclei outlines, the method comprising the steps of: finding candidate nuclei outlines in a first image of a training biopsy; generating an outline image of the found candidate nuclei outlines; overlaying the outline image of the candidate nuclei outlines over the same areas of the first image of the training biopsy where the nuclei outlines were found, on an interactive graphical user interface; labeling a first group of nuclei in the image of the training biopsy with a first label using ones of the candidate nuclei outlines in the outline image having a first visual characteristic, each of the nuclei in the first group being overlaid by a corresponding one of the candidate nuclei outlines having the first visual characteristic; labeling a second group of nuclei in the image of the training biopsy with a second label using ones of the candidate nuclei outlines in the outline image having a second visual characteristic, at least one of the nuclei in the second group being overlaid by a corresponding one of the candidate nuclei outlines having the second visual characteristic; and training the classifier for use in the automatic filtering of unlabeled nuclei outlines obtained from an image of a subject biopsy, using features of the nuclei labeled with the first and second labels, the features capturing at least one of an edge map response along the outline of the labeled nuclei, a texture within the outline of the labeled nuclei, and a geometry of the outline of the labeled nuclei.