Patent ID: 6964769

Claim:
A composition comprising: (a) a non-natural molecular scaffold comprising: (i) a virus-like particle that is a dimer or a multimer of a polypeptide comprising, as a core particle, a polypeptide having the amino acid sequence of SEQ ID NO:158, modified such that the cysteine residues at positions 48 and 110 of SEQ ID NO:158 (corresponding to positions 48 and 107 of SEQ ID NO:134) are either deleted or substituted with another amino acid, or a sequence having at least 90% sequence identity to said polypeptide sequence and in which the cysteine residues at positions 48 and 110 of SEQ ID NO:158 are either deleted or substituted with another amino acid; and (ii) an organizer comprising at least one first attachment site, wherein said organizer is connected to said core particle by at least one covalent bond; and (b) an antigen or antigenic determinant with at least one second attachment site, said second attachment site being selected from the group consisting of: (i) an attachment site not naturally occurring with said antigen or antigenic determinant; and (ii) an attachment site naturally occurring with said antigen or antigenic determinant, wherein said second attachment site is capable of association through at least one non-peptide bond to said first attachment site; and wherein said antigen or antigenic determinant and said scaffold interact through said association to form an ordered and repetitive antigen array.