Patent ID: 7994162

Claim:
A compound of formula (I) wherein: a) R 1 is independently selected from the group consisting of (C 1 -C 12 )alkyl, (C 2 -C 12 )alkenyl, (C 2 -C 12 )alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkyl(C 1 -C 12 )alkyl, cycloalkyl(C 2 -C 12 )alkenyl, cycloalkyl(C 2 -C 12 )alkynyl, heterocyclyl(C 2 -C 12 )alkyl, heterocyclyl(C 2 -C 12 )alkenyl, heterocyclyl(C 2 -C 12 )alkynyl, aryl(C 1 -C 12 )alkyl, aryl(C 2 -C 12 )alkenyl, aryl(C 2 -C 12 ) alkynyl, heteroaryl(C 1 -C 12 )alkyl, heteroaryl(C 2 -C 12 )alkenyl, and heteroaryl(C 2 -C 12 )alkynyl, the aryl group of each R 1 being optionally substituted with one or more halogens; b) R 2 is selected from the group consisting of (C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, aryl, heteroaryl, (C 1 -C 6 )alkylthio (C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, aryloxy(C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy(C 1 -C 6 )-alkyl; c) R 3 is selected from the group consisting of H, COO(R 5 ), CONH(R 5 ), CO(R 5 ), O(R 5 ) and R 5 ; d) R 4 is independently selected from the group consisting of, F, Cl, Br, N(R 5 ) 2 , NO 2 , CN, COO(R 5 ), CON(R 5 ) 2 , NHCO(R 5 ), NHCOO(R 5 ), OCONH(R 5 ), O(R 5 ) and R 5 , or else two substituents R 4 , attached to 2 adjacent carbons of the phenyl, together form a ring selected from a cycloalkyl, heterocyclyl, aryl and heteroaryl, optionally substituted with one or more R 4 ; e) m has the value, 1, 2, 3 or 4; f) R 5 is independently selected from a doublet of nonbonding electrons, H, (C 1 -C 12 )alkyl, (C 2 -C 12 )alkenyl, (C 2 -C 12 )alkynyl, halo(C 1 -C 12 )alkyl, aryl(C 1 -C 12 )alkyl, heteroaryl(C 1 -C 12 )alkyl, heteroarylaryl(C 1 -C 12 )alkyl, aryl, heteroaryl and cycloalkyl, in which each R 5 is optionally substituted with at least one substituent selected from OH, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, aryl(C 1 -C 4 )alkyl, aryl, heteroaryl(C 1 -C 4 )alkyl, heteroaryl, —N(CH 3 ) 2 , —NH 2 , CONH 2 , each of the Rz is independently selected from the group consisting of H, COO(R 5 ), CONH(R 5 ), CON(R 5 ) 2 , CO(R 5 ) and R 5 , in which each R 5 is independently selected from (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, aryl(C 1 -C 4 )alkyl and heteroaryl(C 1 -C 4 )alkyl, in which each R 5 is optionally substituted with a substituent selected from OH, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, aryl(C 1 -C 4 )alkyl, aryl, heteroaryl(C 1 -C 4 )alkyl and heteroaryl; or a pharmaceutically acceptable acid addition salt of such compound, wherein a heteroaryl is a monocyclic or polycyclic heteroaromatic substituent containing from 1 to 13 carbon atoms and from 1 to 4 heteroatoms selected from oxygen, sulphur, nitrogen and selenium, and heterocyclyl is a saturated or partially unsaturated cyclic hydrocarbon based substituent containing from 1 to 13 carbon atoms and from 1 to 4 heteroatoms selected from oxygen, sulphur, nitrogen and selenium.