Patent ID: 8455515

Claim:
A compound of formula I wherein: R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, F, Cl, Br, I, CN, NO 2 and R11-(C m H 2m )-A n -; m is zero, 1, 2, 3 or 4; n is zero or 1; R11 is hydrogen, methyl or C p F 2p+1 ; A is oxygen, NH, N(CH 3 ) or S(O) q ; p is 1, 2 or 3; q is zero, 1 or 2; R5 is selected from the group consisting of hydrogen, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms and cycloalkyl having 3, 4, 5 or 6 carbon atoms; R6 is selected from the group consisting of hydrogen, OH, F, CF 3 , alkyl having 1, 2, 3 or 4 carbon atoms and cycloalkyl having 3, 4, 5 or 6 carbon atoms; R7 and R8 are each independently selected from the group consisting of hydrogen, F, Cl, Br, CN, CO 2 R12, NR13R14 and R16-(C mm H 2mm )-E nn -; R12 is independently selected from the group consisting of hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms and cycloalkyl having 3, 4, 5 or 6 carbon atoms; R13 and R14 are each independently selected from the group consisting of hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms and cycloalkyl having 3, 4, 5 or 6 carbon atoms; or R13 and R14, together with the nitrogen atom to which they are bonded, form a 4-, 5-, 6- or 7-membered ring in which one CH 2 group may be replaced by NR15, S or oxygen; R15 is selected from the group consisting of hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms and cycloalkyl having 3, 4, 5 or 6 carbon atoms; mm is zero, 1, 2, 3 or 4; nn is zero or 1; R16 is hydrogen, methyl or C pp F 2pp+1 ; E is oxygen or S(O) qq ; pp is 1, 2 or 3; qq is zero, 1 or 2; or a pharmaceutically acceptable salt or trifluoroacetate thereof.