Patent ID: 8865726

Claim:
A compound having the general formula I or a salt thereof, wherein: R 1 is H, (1-6C)alkyl or trifluoromethyl; R 2a is hydrogen or methyl; R 2 is H, (1-6C)alkyl, a 3-6 membered cycloalkyl ring, hetCyc 4 , Ar 2 CH 2 —, (3-6C cycloalkyl)CH 2 —, Ar 3 , hetAr 1 , hetAr 2 , (1-3C alkoxy)(1-3C)alkyl, or a 2-oxo-1,2-dihydropyridinyl ring optionally substituted with (1-6C)alkyl; or R 1 and R 2 together with the atoms to which they are attached form a 5-6 membered carbocyclic ring optionally fused to a benzo ring; each R 3 is independently selected from halogen and (1-6C)alkyl; n is 0, 1 or 2; ring B is a 5-membered heteroaryl ring having 2-3 ring heteroatoms, wherein 2 of said ring heteroatoms are N and the third ring heteroatom when present is selected from N, O and S, wherein ring B is optionally substituted with a substituent selected from (1-6C)alkyl, NH 2 , (1-6C hydroxyalkyl)NH—, (HO) 2 P(═O)OCH 2 —, (1-6C)hydroxyalkyl, and (1-6C alkyl)COOH; X is O or NR 4 ; R 4 is H, (1-6C)alkyl, (1-6C)hydroxyalkyl, (1-6C)dihydroxyalkyl, [(1-6C)alkoxy](1-6C)alkyl-, [(1-6C)alkoxy]-[(1-6C)alkoxy]-(1-6C)alkyl-, Ar 1 CH 2 —, hetCyc 1 , hetCyc 2 (1-2C)alkyl-or hetCyc 3 (1-2C)alkyl-; Ar 1 is phenyl optionally substituted with one or more substituents independently selected from (1-6C)alkoxy, halogen, (1-6C)alkyl and CF 3 ; hetCyc 1 is a carbon-linked 4-6 membered azacyclic ring optionally substituted with a substituent selected from (1-6C)alkyl; hetCyc 2 is a 5-6 membered heterocyclic ring having a ring nitrogen atom and optionally having a second ring heteroatom selected from N and O, wherein said ring is optionally substituted with a substituent selected from (1-6C)alkyl, OH, (1-6C)alkoxy, halogen and oxo; hetCyc 3 is a bridged 8-membered heterocyclic ring having a ring nitrogen atom and optionally having a ring oxygen atom; hetCyc 4 is a 5-6 membered heterocyclic ring having a ring heteroatom selected from N and O; Ar 2 is phenyl optionally substituted with one or more halogen atoms; Ar 3 is phenyl optionally substituted with one or more substituents independently selected from halogen, (1-6C)alkoxy, hetCyc 5 , (1-6C)alkyl and CF 3 ; hetCyc 5 is a 6 membered heterocyclic ring having 1-2 ring nitrogen atoms; hetAr 1 is pyridyl optionally substituted with one or more substituents independently selected from halogen, CF 3 , (1-6C)alkyl and (1-6C)alkoxy; and hetAr 2 is a 5-membered heteroaryl having 1-2 ring heteroatoms independently selected from N and S and optionally substituted with (1-6C)alkyl.