Patent ID: 7169794

Claim:
A compound of the Formula I or pharmaceutically acceptable salts thereof, wherein: X 1 is O, NR 4 (where R 4 is hydrogen or alkyl), S, or CR 5 R 6 (where R 5 and R 6 are independently hydrogen or alkyl) or C═O; Ar 1 is aryl or heteroaryl; R 2 is hydrogen alkyl, acyl, alkoxycarbonyl, aryloxycarbonyl, heteroalkylcarbonyl, heteroalkyloxycarbonyl or —R 21 —R 22 where R 21 is alkylene or —C(═O)— and R 22 is alkyl or alkoxy; R 1 is hydrogen, alkyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl, cyanoalkyl, heterocyclyl, heterocyclylalkyl, R 12 —SO 2 -heterocycloamino (where R 12 is haloalkyl, aryl, aryalkyl, heteroaryl or heteroaralkyl), —Y 1 —C(O)—Y 2 —R 11 (where Y 1 and Y 2 are independently either absent or an alkylene group and R 11 is hydrogen, alkyl, haloalkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), (heterocyclyl)(cycloalkyl)alkyl or (heterocyclyl)(heteroaryl)alkyl; and R 3 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, alkylene-C(O)—R 31 (where R 31 is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), amino, monoalkylamino, dialkylamino or NR 32 —Y 3 —R 33 (where Y 3 is —C(O), —C(O)O—, —C(O)NR 34 , S(O) 2 or S(O) 2 NR 35 ; R 32 , R 34 and R 35 are independently hydrogen or alkyl; and R 33 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or optionally substituted phenyl) or acyl.