Patent ID: 7871602

Claim:
A sterile aqueous ophthalmic composition comprising a bis-amine of the following formula, in an amount effective to enhance the antimicrobial activity of the composition: wherein: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of: H; —CH 2 OH; and C 1 -C 5 straight or branched alkyl or alkenyl, optionally containing one or more heteroatoms, provided that no more than one of R1, R2 and R3 is —CH 2 OH, and no more than one of R4, R5 and R6 is —CH 2 OH; and X is (—CH 2 —) w CHOH—CHOH(—CH 2 —) w , wherein w is a whole number of from 1 to 6 and the hydroxy groups are in either cis or trans configurations; or a pharmaceutically acceptable salt thereof, said composition having a physiologically compatible pH and an osmolality of 210 to 320 mOsm/kg.