Patent ID: 7714127

Claim:
A process of making a compound of the formula (I): said process comprising: in one pot reacting 5-bromo-2-[(4-morpholino)methyl]pyridine compound (e) with i-Pr(n-Bu) 2 MgLi under suitable temperature and solvent conditions, subsequently adding B(OMe) 3 , then adding Pd(OAc) 2 , PPh 3 , K 3 PO 4 , IPA, and 1-amino-4-bromonaphthalene (a) and subsequently adding HCl, IPAc and MeOH at ambient temperature to provide compound (I) as an HCl salt, and converting the HCl salt of compound (I) to the free base of compound (I) by treatment with a base where prior to the addition of HCl, IPAc and MeOH, the reaction is conducted in one pot and no intermediates are isolated: