Patent ID: 8513282

Claim:
A method of treating or lessening the severity of a disease in a patient, wherein the disease is cystic fibrosis, COPD, smoked induced COPD, hereditary emphysema, pancreatitis, pancreatic insufficiency or dry-eye disease, said method comprising the step of administering to said patient an effective amount of a compound of Formula (I): or pharmaceutically acceptable salts thereof, wherein ring A is selected from R 1 is —CF 3 , —CN, or —C≡CCH 2 N(CH 3 ) 2 ; R 2 is hydrogen, —CH 3 , —CF 3 , —OH, or —CH 2 OH; and R 3 is hydrogen, —CH 3 , —OCH 3 , or —CN; provided that both R 2 and R 3 are not simultaneously hydrogen.