Patent ID: 8785489

Claim:
A compound of the formula (I): Het is a ring chosen from phenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl and pyridazinyl each optionally substituted by one to three C 1-5 alkyl, C 1-5 alkoxy, C 1-5 acyl, C 1-5 acylamino, amino, cyano, hydroxyl or halogen; X is —N(R 3 )—; Y is N or CH; Z is H or F; R 1 is chosen from C 1-5 alkoxyC 1-5 alkyl, C 1-5 alkoxycarbonyl-(CH 2 ) n —, —C(O)NR 4 R 5 and Ar 1 ; R 2 is chosen from Ar 2 —(CH 2 ) n —, heterocycle and C 1-5 alkyl; R 3 is chosen from hydrogen and C 1-5 alkyl; each R 4 and R 5 is independently chosen from hydrogen, C 1-5 acyl, C 1-5 alkyl, C 1-5 alkoxy, hydroxyl, carbocycle-(CH 2 ) n —, heteroaryl and heterocycle-(CH 2 ) n —; Ar 1 is chosen from carbocycle, heteroaryl and heterocycle wherein Ar 1 is optionally substituted by one to three C 1-5 alkyl, C 1-5 alkoxy, C 1-5 acyl, C 1-5 acylamino, amino, cyano, hydroxyl or halogen; Ar 2 is chosen from carbocycle, heteroaryl and heterocycle wherein Ar 2 is optionally substituted by one to three heteroaryl, C 1-5 alkyl, C 1-5 alkoxy-(CH 2 ) n —, C 1-5 alkoxycarbonyl-(CH 2 ) n —, carboxy-(CH 2 ) n —, C 1-5 acyl, C 1-5 acylamino, amino, cyano, hydroxyl, sulfonyl, sulfoxide, thio, oxo or halogen; each n is independently 0-2; or a pharmaceutically acceptable salt thereof.