Patent ID: 6872730

Claim:
A compound having the Formula I: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein R 1 represents hydrogen, alkyl, haloalkyl, aryl or aralkyl; R 2 , R 3 and R 4 independently represent hydrogen, alkyl, haloalkyl, aryl or aralkyl; Y is sulfur; R 5 , R 6 , R 7 and R 8 independently represent: hydrogen; hydroxy; alkyl; haloalkyl; alkoxy; haloalkoxy; cycloalkyl; aryl; or heterocycle having 5-14 ring members, optionally substituted with one or more of halogen, hydroxy, cyano, alkyl, haloalkyl, alkoxy, aryl or arylalkyl, arylalkoxy, aryloxy, alkylsulfonyl, alkyl sulfinyl, alkylalkoxyaryl, mono- or di-alkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkanoyl, carboxyalkyl; further wherein: aryl or the aryl group of any aryl-containing moiety may be optionally substituted by one or more of: halogen, hydroxy, cyano, alkyl, aryl, alkoxy, haloalkyl, arylalkyl, arylalkoxy, aryloxy, alkylsulfonyl, alkylsulfinyl, alkylalkoxyaryl, mono- or di-alkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkanoyl, carboxyalkyl; or R 5 and R 7 are taken together to form —(CH 2 ) s , wherein s is 0 or 1 to 4, while R 6 and R 8 are defined as above; or R 6 and R 8 are taken together to form —(CH 2 ) t —, wherein t is 2 to 8, while R 5 and R 7 are defined as above; or R 7 and R 8 are taken together to form —(CH 2 ) u — wherein u is 2 to 8, while R 5 and R 6 are defined as above; i is from 0 to 4; j is from 0 to 4; and k is 0 or 1; R 9 is hydrogen or a functionality which acts as a prodrug, selected from the group consisting of: alkyl, haloalkyl, aryl, aralkyl, dialkylaminoalkyl, 1-morpholinoalkyl, 1-piperidinylalkyl, pyridinylalkyl, alkoxy(alkoxy)alkoxyalkyl, or (alkoxycarbonyl)oxyethyl, R 10 , R 11 , R 12 and R 13 independently represent hydrogen, alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, carboxylalkyl, aryl or aralkyl; or R 10 and R 11 are taken together to form —(CH 2 ) p —, where p is 2-8, while R 12 and R 13 are defined as above; or R 12 and R 13 are taken together to form —(CH 2 ) q —, where q is 2-8, while R 10 and R 11 are defined as above; or R 10 and R 12 are taken together to form —(CH 2 ) r —, while r is zero, 1 or 2, while R 11 and R 13 are defined as above; X represents; oxygen, sulfur, CH 2 or NH; n is from 0 to 4; m is from 0 to 4; W is: wherein: A, G and M are independently oxygen, sulfur, CH 2 , CH—R a , C(R a )(R b ), NH or N—R a , wherein R a and R b , are independently selected from alkyl, haloalkyl or aryl; Y′ is NH, sulfur or CH; Z is N or CH; R 15 is hydrogen, alkyl, haloalkyl, aryl or aralkyl; and R 14 is hydrogen, alkyl, haloalkyl or halogen.