Patent ID: 8415352

Claim:
A pharmaceutical composition, wherein the composition is sterile and suitable for pharmaceutical administration and comprises a compound of formula (I) and a pharmaceutically acceptable carrier, adjuvant, diluent or excipient: wherein: R1 is: hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, alkyloxyalkyl, R7R8N-alkyl, alkylthioalkyl; heterocycloalkyl and heteroaryl groups can include one or more heteroatoms selected from N, O and S; each of these groups can be optionally substituted by one or more groups selected from Y or Z; R6 is: alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, aryloxyalkyl, arylalkyloxyalkyl, arylthioalkyl, arylsulfinylalkyl, arylsulfonylalkyl, arylalkylthioalkyl, arylalkylsulfinylalkyl, arylalkylsulfonylalkyl, heteroarylalkyl, heteroaryloxyalkyl, heteroarylalkoxyalkyl, heteroarylthioalkyl, heteroarylsulfinylalkyl, heteroarylsulfonylalkyl, heteroarylalkylthioalkyl, heteroarylalkylsulfinylalkyl, heteroarylalkylsulfonylalkyl, heterocycloalkylalkyl, heterocycloalkyloxyalkyl, heterocycloalkylalkyloxyalkyl, heterocycloalkylthioalkyl, heterocycloalkylsulfinylalkyl, heterocycloalkylsulfonylalkyl, heterocycloalkylalkylthioalkyl, heterocycloalkylalkylsulfinylalkyl, heterocycloalkylalkylsulfonylalkyl; heteroaryl or heterocycloalkyl groups can include one or more heteroatoms selected from N, O and S; each of these groups can be optionally substituted by one or more groups selected from Y or Z; R2, R3, R4 and R5 are independently selected from hydrogen, Y or Z; Y is: alkyl, cycloalkyl, heterocycloalkyl, alkoxy, heteroaryl, aryl, alkylsulfonyl, aryloxy, arylalkoxy, alkylsulfinyl, alkylthio; heteroaryl or heterocycloalkyl groups can include one or more heteroatoms selected from N, O and S; each of these groups can be optionally substituted by one or more groups selected from Z; Z is: hydroxy, thio, halogen, cyano, trifluoromethoxy, trifluoromethyl, carboxy, carboxymethyl, carboxyethyl, alkyl, cycloalkyl, alkoxy, NR7R8, azido, nitro, guanidino, amidino, phosphono, oxo, alkylthio, alkylsulfonyl, SF S , two Y groups can form a methylenedioxy; R7 and R8 are independently selected from: hydrogen; lower alkyl, cycloalkyl; R7 and R8 can also constitute a heterocycloakyl group, which can include one or more heteroatoms selected from N, O and S; R7 and R8 independently can be optionally substituted by one or more substituents selected from Z; or its racemic forms, tautomers, enantiomers, diastereomers, epimers and mixtures thereof, and the pharmaceutically acceptable salts thereof.