Patent ID: 8420145

Claim:
A compound having structural formula (I) or the salt, solvate, ester, or N-oxide thereof, wherein: A is aryl, or heteroaryl, selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, furanyl, thiofuranyl, oxazoloyl, isoxazoloyl, thiazolyl, and triazole; Y is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heterocyclyl, substituted heterocyclyl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, carbocyclyl, substituted carbocyclyl, acyl, halo, —CN, —NO 2 , —OR 1 , —S(O)R 1 , —S(O) 2 R 1 , —OC(O)R 1 , —N(R 1 )C(O)R 2 , —NR 1 R 2 , —C(O)NR 1 R 2 , —C(O)OR 1 , —S(O) 2 NR 1 R 2 , —COR 1 , —N(R 1 )S(O) 2 R 2 , —SR 1 , —C(R 1 R 2 R 6 ), —C(S)—R 1 , —C(═NR 2 )—R 1 , —N(R 1 )—C(═N—OR 2 )R 6 , —N(R 1 )C(S)NR 2 R 6 , —C(═N—OR 1 )R 2 , —C(═NR 1 )—NR 2 R 6 , —N(R 1 )C(═NR 2 )NR 6 R 7 , —N(R 1 )C(S)R 2 , —N(R 1 )—C(O)—C(O)R 2 , —C(S)—NR 1 R 2 , —N(R 1 )C(═NR 2 )OR 6 , —C(═NR 1 )O—NR 2 R 6 , —N(R 1 )N(R 2 )C(O)OR 6 , —N(R 1 )C(O)OR 2 , —N(R 1 )C(O)NR 2 R 6 , —N(R 1 )—C(O)—C(O)—NR 2 R 6 , —C(O)—C(O)—NR 1 R 2 , —P(O)(OR 1 )(OR 2 ), —P(O)(OR 1 )(R 2 ), or —P(O)R 1 R 2 ; X is —O—, —S—, —S(O)—, —S(O) 2 —, —C(R 3 R 4 )—, —C(O)—, —C(S)—, —C(═NR 3 )—, —C(O)O—, —N(R 3 )—, —OC(O)—, —N(R 3 )C(O)—, —C(O)N(R 3 )—, —N(R 3 )—C(═N—OR 4 )—, —C(═N—OR 3 )—, —C(═NR 3 )—NR 4 —, —N(R 3 )C(S)N(R 4 )—R 5 , —N(R 3 )C(O)N(R 4 )—R 5 , —N(R 3 )C(═NR 4 )—, —N(R 3 )C(S)—, —N(R 3 )—C(O)—C(O)—, —C(S)—N(R 3 )—, —N(R 3 )S(O) 2 —, —S(O) 2 —N(R 3 )—, —N(R 3 )C(═NR 4 )O—, —C(═NR 4 )O—N(R 3 )—, —N(R 3 )—C(═NR 4 )—N(R 5 )—, —N(R 3 )N(R 4 )C(O)O—, —N(R 3 )C(O)O—, —N(R 3 )C(O)N(R 4 )—, —N(R 3 )—C(O)—C(O)—NR 4 —, —C(O)—C(O)—NR 4 —, —P(O)(OR 3 )—, or —P(O)R 3 —; Z is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclylalkyl, substituted heterocyclylalkyl, carbocyclyl, or substituted carbocyclyl; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are each independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkylnyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, carbocyclyl, substituted carbocyclyl, heteroarylalkyl, or substituted heteroarylalkyl; and with the following proviso: when A is triazole; then —X—Z is not —O-alkyl, —O-acyl, or sulfonamide.