Patent ID: 7541379

Claim:
A method for the treatment of osteoporosis comprising contacting osteoblastic cells with an effective amount of one or more di(amido-substituted) heteroarene compounds having the structural formula A in a pharmaceutically acceptable vehicle: wherein positions R 1 , R 2 , R 3 and R 4 are each independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, nitro, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, phenylthio, substituted phenylthio, cyano, isocyano, substituted isacyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfinyl, substituted sulfinyl, sulfonyl, substituted sulfonyl, sulfonic acid, substituted sulfonic acid, phosphonato, substituted phosphonato, phosphoramide, polyaryl, substituted polyaryl, C 1 -C 20 cyclic, C 1 -C 20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, or polypeptide group; X is O, 8 or NR 5 where R 5 is independently selected from the same groups as R 1 ; n and m may be C 1 -C 20 ; Y is independently selected from the same groups as R 1 or is SO 2 and wherein R 1 through R 4 may be optically pure or a stereo- or region-isomer.