Patent ID: 8003648

Claim:
A compound having the formula I′: or a pharmaceutically acceptable salt, stereoisomer, or C 1 -C 6 alkyl ester thereof, or a tautomer or a pharmaceutically acceptable salt, stereoisomer, or C 1 -C 6 alkyl ester thereof, or a mixture thereof, wherein Q is hydrogen, aryl, heteroaryl, (C 1 -C 6 )alkyl, or (C 2 -C 6 )heteroalkyl; L 1 is a bond, (C 1 -C 4 )alkylene, (C 2 -C 4 )heteroalkylene, O, S(O) k , N(R a ), C(O)—(C 5 -C 7 )heterocycloalkylene, (C 1 -C 4 )alkylene-SO 2 N(R b ), (C 1 -C 4 )alkylene-N(R b )SO 2 , or C(O)N(R b ); represents an optionally substituted benzo-fused (C 5 -C 8 )cycloalkane ring wherein the optionally substituted benzo-fused (C 5 -C 4 )alkylene-N(R b )S) 2 , or a benzene ring fused to a (C 5 -C 8 ) cycloalkane ring, an optionally substituted heterobenzo-fused (C 5 -C 8 )cycloalkane ring wherein the heterobenzo-fused (C 5 -C 8 )cycloalkane ring has a six-membered heteroaryl ring having 1 or 2 N atoms fused to a (C 5 -C 8 ) cycloalkane ring, or a heteroaryl-fused (C 5 -C 8 )cycloalkane ring wherein the heteroaryl-fused (C 5 -C 8 )cycloalkane ring has a five-membered heteroaryl ring having 1 or 2 heteroatoms fused to a (C 5 -C 8 )cycloalkane ring, wherein the benzene ring of the benzo-fused (C 5 -C 8 )cycloalkane ring, the heteroaryl ring of the heterobenzo-fused (C 5 -C 8 )cycloalkane ring, or the heteroaryl ring of the heteroaryl-fused (C 5 -C 8 )cycloalkane ring is bonded to L 2 or M, if L 2 is a bond; L 2 is a bond, (C 1 -C 6 )alkylene, (C 2 -C 6 )heteroalkylene, oxymethylene, O, S(O) k , N(R a ), C(O)N(R b ), SO 2 N(R b ), (C 1 -C 4 )alkylene-C(O)N(R b ), (C 1 -C 4 )alkylene-N(R b )C(O), (C 2 -C 4 )alkenylene-C(O)N(R b ), (C 2 -C 4 )alkenylene-N(R b )C(O), (C 1 -C 4 )alkylene-SO 2 N(R b ), (C 1 -C 4 )alkylene-N(R b )SO 2 , (C 2 -C 4 )alkenylene-SO 2 N(R b ), or (C 2 -C 4 )alkenylene-N(R b )SO 2 ; M is an aromatic ring, a heteroaromatic ring, (C 5 -C 8 )cycloalkylene, aryl(C 1 -C 4 )alkylene, or heteroaryl(C 1 -C 4 )alkylene; X is CR 1 R 1′ ; L 3 is a (C 1 -C 5 )alkylene or (C 2 -C 5 )heteroalkylene; A is —CO 2 H, tetrazol-5-yl, —SO 3 H, —PO 3 H 2 , —SO 2 NH 2 , —C(O)NHSO 2 CH 3 , thiazolidinedionyl, hydroxyphenyl, or pyridyl; R a is hydrogen, (C 1 -C 6 )alkyl, aryl(C 1 -C 3 ) alkyl, or (C 2 -C 6 )heteroalkyl; R b is hydrogen, (C 1 -C 6 )alkyl, or (C 2 -C 6 )heteroalkyl; R 1 is a group of formula: R 1a is selected from H, or (C 1 -C 6 )alkyl; R 1b is selected from H, or (C 1 -C 6 )alkyl; R 1′ is hydrogen, cyano, aryl, heteroaryl, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, or (C 2 -C 8 )alkynyl; and the subscript k is, in each instance, independently selected from 0, 1, or 2.