Patent ID: 6916923

Claim:
A method of making a compound of formula I comprising (a) reacting a compound of formula with hydrazine; and (b) oxidizing the resulting dihydropyrazole to a pyrazole; wherein: R 1 is selected from the group consisting of —H, —NO 2 , —CN, -halogen, -lower alkyl which is straight-chained and which optionally may be substituted by the group consisting of —OH and halogen, —OR 5 , —R 6 OR 7 , —COOR 7 , —CONR 8 R 9 , —NR 10 R 11 , —NHCOR 12 , and —NHSO 2 R 13 ; R 2 and R 4 are each independently selected from the group consisting of —H, -halogen, —NO 2 , —CF 3 , and -straight chained lower alkyl; R 3 selected from the group consisting of —H, -lower alkyl which optionally may be substituted by —OH, —OR 9 , F, and aryl, -cycloalkyl, -aryl, -heterocycle, -heteroaryl, —COOR 7 —CN, -alkenyl, —CONR 8 R 9 , and -alkynyl; R 5 selected from lower alkyl which optionally may be substituted by halogen; R 6 is selected from lower alkylene; R 7 is selected from the group consisting of —H and lower alkyl; R 8 and R 9 are each independently selected from the group consisting of —H and -lower alkyl which itself optionally may be substituted by —OH and —NH 2 ; alternatively, R 8 and R 9 may form a 5- or 6-membered heterocycle which optionally may be substituted by the group consisting of —OH, —NH 2 , and lower alkyl; R 10 , R 11 and R 12 are each independently selected from the group consisting of —H and lower alkyl; R 13 is selected from the group consisting of lower alkyl which optionally may be substituted by the group consisting of halogen and —NR 14 R 15 ; and R 14 and R 15 are each independently selected from the group consisting of —H and lower alkyl which optionally may be substituted halogen, or alternatively, —NR 14 R 15 is a heterocycle.