Patent ID: 7024955

Claim:
A method for determining a dissolution profile for a sample material, the method comprising dissolving at least a portion of the sample material in a solvent over a period of time to form a solution, the period of time defining a dissolution period, the solution having a concentration of the sample material that varies during the dissolution period, sampling a portion of the solution at least twice during the dissolution period, the solution being sampled at a first time within the dissolution period to obtain a first aliquot of the solution, and at a later second time within the dissolution period to obtain a second aliquot of the solution, subsampling a portion of the first aliqout of the solution to obtain a first sub-aliquot of the solution resulting in a remainder portion of the first aliquot, determining the concentration of the sample material in the first sub-aliquot of the solution, returning the remainder portion of the first aliquot to the solution, subsampling a portion of the second aliqout of the solution to obtain a second sub-aliquot of the solution resulting in a remainder portion of the second aliquot, determining the concentration of the sample material in the second sub-aliquot of the solution, and returning the remainder portion of the second aliquot to the solution.