Patent ID: 8193178

Claim:
A chemical entity selected from the group consisting of compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein X is O; R 1 and R 2 taken together form —CH 2 ) 4-5 — optionally substituted with one or two substituents independently selected from methyl and fluoro; —N(R 3 )R 4 is one of the following moieties: where q is 0 or 1; R 3 and R 4 are taken together or separately as defined by the structure of each one of said moieties; R a is H or OH; R b and R c are each independently H or C 1-3 alkyl; R d is H or a C 1-3 alkyl group unsubstituted or substituted with OH or NH 2 ; each R e substitutent is methyl or two R e substituents taken together form a methylene or ethylene bridge; and R 5 is H or NH 2 .