Patent ID: 7364768

Claim:
A method for coating a medical device comprising: (a) reacting the surface of a medical device with a silane-based activating reagent to form a polymerized silane derivative covalently bonded to the surface of the medical device, said polymerized silane derivative containing hydroxyl or other functional groups that can be transformed into hydroxyl groups; (b) reacting the device of step (a) with at least one lactone monomer in the presence of a metal catalyst to form a lactone polymer chain covalently bonded to the polymerized silane derivative, said chains grown on the hydroxyl or amino functional groups of the silane derivative through in-situ ringopening graft polymerization of lactone monomers, said polymerization initiated by said hydroxyl or amino functional groups of the silane derivative covalently bonded to the surface of the medical device, said lactone polymer chains and said silane derivative together forming a grafted lactone polymer layer; and (c) treating the device of step (b) with at least one polyester polymer layer deposited on the grafted lactone polymer layer, wherein at least the first of the deposited polyester polymer layers is chemically compatible with the grafted lactone polymer layer to allow for entanglement of said deposited polyester polymer chains with the chains of said grafted lactone polymer chains for strong adhesion.