Patent ID: 8530519

Claim:
A method for promoting bicarbonate secretion in the upper gastrointestinal tract in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a compound represented by Formula (I) and/or its tautomer: wherein A is —COOH or its pharmaceutically acceptable salt or ester; X 1 and X 2 are both halogen atoms; W 1 is ═O; W 2 is wherein R 3 and R 4 are both hydrogen atoms; Y is an unsubstituted saturated or unsaturated hydrocarbon chain having 6-8 carbon atoms; R 1 is a straight or branched hydrocarbon containing 1-6 carbon atoms; and R 2 is hydrogen; the bond between C-13 and C-14 position is double or single bond, and the steric configuration at C-15 position is R, S, or a mixture thereof.