Patent ID: 8299296

Claim:
A spiro compound of the following general formula [Ia]: or a pharmaceutically acceptable salt thereof, wherein: R 1 is (1) a hydrogen atom, (2) a C 1 -C 6 alkyl group, (3) a C 2 -C 6 alkenyl group, (4) a C 2 -C 6 alkynyl group, (5) a C 1 -C 6 alkoxy group, (6) a hydroxy C 1 -C 6 alkyl group, (7) a C 1 -C 6 alkoxy(C 1 -C 6 )alkyl group, (8) —CONR 11 R 12 in which R 11 and R 12 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl group, (9) a phenyl group or (10) a five-membered heteroaryl group which has at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, and which is optionally substituted by a C 1 -C 6 alkyl group; R 2 is (1) a halogen atom, (2) a C 1 -C 6 alkyl group, (3) a hydroxy group or (4) a C 1 -C 6 alkoxy group; p is 0, 1, 2 or 3; X is a carbon atom or a nitrogen atom; m1 is 0, 1 or 2; m2 is 0 or 1; spiro-ring AB is optionally substituted by 1 to 5 same or different substituent(s) selected from the group consisting of (1) a hydroxy group, (2) a C 1 -C 6 alkyl group, (3) a C 1 -C 6 alkoxy group and (4) an oxo group; n1 is 0, 1, 2, 3 or 4; n2 is 1, 2, 3 or 4; n3 is 0, 1 or 2 with the proviso that n2+n3 is 2, 3 or 4; and a bond represented by the symbol: means a single bond or a double bond with the proviso that three contiguous carbon atoms do not constitute an allene bond represented by the formula: C═C═C.