Patent ID: 7326715

Claim:
A 4-phenyl-6-substituted-pyrimidine-2-carbonitrile compound having the general formula I wherein R represents 1-3 optional substituents independently selected from (C 1-4 )alkyl optionally substituted with one or more halogens, (C 1-4 )alkyloxy optionally substituted with one or more halogens and halogen; X is NR 1 , O or S; R 1 is H or (C 1-4 )alkyl; Y is (C 1-4 )alkyl, benzyl or (C 2-6 )alkyl, substituted with a group selected from OH, (C 1-4 )alkyloxy, NR 2 R 3 , a 4-8 membered saturated heterocyclic ring comprising 1 or 2 heteroatoms selected from O, S and NR 4 , and a 5 or 6-membered aromatic heterocyclic group comprising 1-4 N atoms; or R 1 and Y form together with the nitrogen to which they are bonded a 5-8 membered saturated heterocyclic ring, optionally comprising a further heteroatom selected from O, S, NR 4 and NO; the ring being optionally substituted with NR 2 R 3 or with 1 to 4 (C 1-3 )alkyl groups; R 2 and R 3 are independently H or (C 1-4 )alkyl; or R 2 and R 3 form together with the nitrogen to which they are bonded a 4-8 membered saturated heterocyclic ring, optionally comprising a further heteroatom selected from O, S and NR 4 ; R 4 is H, (C 1-6 )alkyl, (C 3-6 )cycloalkyl, (C 3-6 )cycloalkyl(C 1-4 )alkyl, (C 1-4 )alkyloxy(C 1-4 )alkyl, benzyl, amido(C 1-4 )alkyl, (C 1-6 )alkyloxycarbonyl(C 1-4 )alkyl or carboxy(C 1-4 )alkyl; or a pharmaceutically acceptable salt thereof.