Patent ID: 7138389

Claim:
A method of providing androgen therapy to a human subject, said method comprising: administering to the subject a modulator of testosterone bioavailability, wherein the modulator is a compound having the formula: wherein R 1 is hydrogen or lower alkyl, and R 2 is optionally substituted alkyl or optionally substituted phenyl wherein the phenyl has 0, 1, 2, or 3 substituents selected from the group consisting of lower alkyl, halogen, and trifluoromethyl, and R 3 , R 4 , R 5 , and R 6 are independently selected from the group consisting of hydrogen and optionally substituted lower alkyl, and the bond between adjacent carbon atom a and carbon atom b can optionally be replaced by a single bond in which the adjacent carbons are independently substituted with hydrogen or methyl, and the pharmaceutically acceptable salts thereof; and orally administering in an oil vehicle-an androgen selected from the group consisting of testosterone, testosterone esters, and testosterone precursors.