Patent ID: 7342019

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, in which R 1 and R 2 independently represent: a C 1-6 alkyl group; an (amino)C 1-4 alkyl-group in which the amino is optionally substituted by one or more C 1-3 alkyl groups; an optionally substituted non-aromatic C 3-15 carbocyclic group; a (C 3-12 cycloalkyl)C 1-3 alkyl-group; a group —(CH 2 ) r (phenyl) s in which r is 0, 1, 2, 3 or 4, s is 1, and the phenyl group is optionally independently substituted by one, two or three groups represented by Z; naphthyl; anthracenyl; a saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen wherein the heterocyclic group is optionally substituted by one or more C 1-3 alkyl groups, hydroxy or benzyl; 1-adamantylmethyl; a group —(CH 2 ) t Het in which t is 0, 1, 2, 3 or 4, (CH 2 ) t is optionally substituted by one or more C 1-3 alkyl groups and Het represents an aromatic heterocycle optionally substituted by one, two or three groups selected from a C 1-5 alkyl group, a C 1-5 alkoxy group or halo; or R 1 represents H and R 2 is as defined above; or R 1 and R 2 together with the nitrogen atom to which they are attached represent a saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen; wherein the heterocyclic group is optionally substituted by one or more C 1-3 alkyl groups, hydroxy or benzyl; X is CO or SO 2 ; Y is absent or represents NH optionally substituted by a C 1-3 alkyl group; R 3 and R 4 independently represent phenyl, thienyl or pyridyl each of which is optionally substituted by one, two or three groups represented by Z; Z represents a C 1-3 alkyl group, a C 1-3 alkoxy group, hydroxy, halo, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, trifluoromethylsulphonyl, nitro, amino, mono or di C 1-3 alkylamino, mono or di C 1-3 alkylamido, C 1-3 alkylsulphonyl, C 1-3 alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C 1-3 alkyl carbamoyl, sulphamoyl and acetyl; and R 5 is H, a C 1-3 alkyl group, a C 1-3 alkoxymethyl group, trifluoromethyl, a hydroxyC 1-3 alkyl group, C 1-3 alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C 1-3 alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula —CONHNR a R b wherein R a and R b are as previously defined for R 1 and R 2 respectively and; with the proviso that when R 1 and R 2 together with the nitrogen atom to which they are attached represent 4-methylpiperazin-1-yl or R 1 represents H and R 2 represents methyl or 1-benzylpiperidin-4-yl; X is CO; Y is absent and R 5 is H; then R 3 and R 4 do not both represent 4-methoxyphenyl.