Patent ID: 7410972

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which: R 1 , R 2 and R 3 are independently hydrogen, halogen, cyano, CF 3 , or C 1-6 alkyl; R 4 is halogen, CO 2 R 12 , C 1-6 alkoxy where the alkyl group may form a 3-6 membered saturated ring or may be substituted with 1-3 fluorine atoms or a cyano group; C 3-6 alkenyloxy or C 3-6 alkynyloxy where either may be optionally substituted with hydroxy or NR 14 R 15 ; OC 1-6 alkyl-X—C 1-6 alkyl where the alkyl groups may form a 3-6 membered saturated ring; OC 1-6 alkylR 11 , or OC 2-6 alkyl-X—R 11 where the alkyl group may form a 3-6 membered saturated ring and is optionally substituted with 1-3 groups selected from hydroxy, halogen, NR 14 R 15 , SR 13 , S(O) 2 R 13 , S(O) 13 ; OC 1-6 alkylR 16 ; R 5 and R 6 are independently hydrogen, cyano, halogen, CO 2 R 12 , CONR 14 R 15 ; C 1-6 alkyl optionally substituted by hydroxy, NR 14 R 15 , or 1-3 fluorines; C 1-6 alkylR 11 or XCH(R 11 )C 1-6 alkyl or XCH(R 16 )C 1-6 alkyl where the alkyl group may be optionally substituted with 1-3 groups selected from hydroxy, and NR 14 R 15 ; NR 14 R 15 ; N(R 11 )R 11 ; X—(CH 2 )qNR 14 R 15 ; (CH 2 )nNR 14 R 15 ; C 3-6 alkynyl or C 3-6 alkenyl optionally branched and optionally substituted with 1-3 groups selected from hydroxy, cyano, halogen and ═O; R 11 ; X—R 11 ; X—R 12 ; X—C 1-6 alkylR 16 ;X—R 16 ; X—(CH 2 )nCO 2 R 12 ; X—(CH 2 )nCONR 14 R 15 ; X—(CH 2 )nR 11 ; X—(CH 2 )nCN; X—(CH 2 )qOR 12 ; (CH 2 )nOR 12 ; (CH 2 )n-X—R 11 ; X—(CH 2 )qNHC(O)NHR 12 ; X—(CH 2 )qNHC(O)R 12 ; X—(CH 2 )qNHS(O) 2 R 12 ; X—(CH 2 )qNHS(O) 2 R 11 ; X—C 3-6 alkenyl; X—C 3-6 alkynyl; n is 1 ,2, 3, 4 or 5; q is 2, 3, 4, 5 or 6; X is NR 13 , O, S, S(O), S(O) 2 ; R 11 is an aryl group or a 5-7 membered heteraromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur each of which can be optionally substituted by 1-3 groups selected from halogen, C(O)NR 14 R 15 , C(O)OR 12 , hydroxy, ═O,═S, CN, NO 2 , NR 14 R 15 , X(CH 2 )qNR 14 R 15 , (CH 2 )nNR 14 R 15 , (CH 2 )nOH, SR 13 , S(O)R 13 , S(O) 2 R 13 C 1-6 alkyl-X—C 1-6 alkyl, C 1-6 alkyl or C 1-6 alkoxy where the alkyl group may form a 3-6 membered ring or is optionally substituted with 1-3 groups selected from hydroxy, halogen, NR 14 R 15 , SR 13 , S(O)R 13 , S(O) 2 R 13 ; R 12 and R 13 are independently hydrogen or C 1-6 alkyl where the alkyl group may be substituted with 1-3 fluorine atoms or may form a saturated 3-6 membered ring; R 14 and R 15 are independently hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl or (CH 2 )qOH, or R 14 and R 15 together with the nitrogen atom to which they are attached form a 4-8 membered saturated ring containing 1-3 heteroatoms selected from nitrogen, oxygen and sulphur and optionally substituted by C 1-6 alkyl, C 1-6 alkyl-OH, or hydroxy; and R 16 is a 4-8 membered saturated ring containing 1-3 heteroatoms selected from nitrogen, oxygen or sulphur and optionally substituted with 1-3 groups selected from hydroxy, cyano, halogen and ═O.