Patent ID: 8852593

Claim:
A method for preventing recognition of a therapeutic antibody Fab fragment by pre-existing anti-Fab antibodies comprising attaching a molecule to the c-terminus of the Fab fragment that masks a Fab-specific neoepitope at the c-terminus of the Fab fragment without interfering with the binding of the antibody Fab fragment to its target, thereby preventing recognition of the Fab-specific neoepitope by the pre-existing anti-Fab antibodies and preventing platelet activation and associated side effects, wherein the antibody Fab fragment is an antibody Fab fragment that specifically binds to human platelet membrane protein Glycoprotein VI (GPVI) and induces a GPVI depletion phenotype, wherein the antibody Fab fragment binds to a conformational epitope of human GPVI and contacts human GPVI amino acid residues Ser 43, Arg 67, and Asp 81.