Patent ID: 7220783

Claim:
An anti-allergic agent comprising the compound of the formula (I″) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl optionally substituted, lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl, X is —O—, —CH 2 —, —NR 14 — wherein R 14 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p- wherein p is an integer of 0 to 2, Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH 2 — and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR 14 —, R 1 and R 4 , R 1 and R 2 , R 2 and R 3 , R 4 and R 5 , R 6 and R 7 , R 8 and R 9 , R 10 and R 11 , R 12 and R 13 , R 11 and —X—Y, or R 13 and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR 15 wherein R 15 is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or optionally substituted arylsulfonyl and which may optionally be substituted, excluding a compound of the formula (I′): wherein R 1′ is hydrogen or hydroxy and R 13′ is hydroxy or methoxy; or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable excipient.