Patent ID: 7019172

Claim:
A process for the preparation of S-(−)-betaxolol of the formula (3) and hydrochloride or maleate salt of the formula (1) which comprises a. selectively benzylating 2-[4-hydroxyphenyl-ethanol] with benzyl halide in the presence of base and an organic solvent to obtain 2-[4-benzyloxyphenyl-ethanol]; b. condensing 2-[4-benzyloxyphenyl-ethanol] with an allyl halide in the presence of a base and an organic solvent to obtain 1-(2-allyloxyethyl)-4-benzyloxybenzene; c. cyclopropanating 1-(2-allyloxyethyl)-4-benzyloxybenzene to obtain the 1-benzyloxy-4-(2-cyclopropyl methoxy-ethyl)-benzene; d. deprotecting 1-benzyloxy-4-(2-cyclopropylmethoxy-ethyl)-benzene by hydrogenation to obtain 4-(2-cyclopropylmethoxyethyl)-phenol; e. O-Alkylating the 4-(2-cyclopropylmethoxyethyl)-phenol to S(−)-betaxolol by treating with R-(−)-epichlorohydrin in the presence of alkali to obtain a mixture of compounds and treating the mixture with isopropylamine to give S-(−)-betaxolol of formula 3, and if desired f. treating S-(−)-betaxolol with alcoholic hydrochloric acid in organic solvent to give S-(−)-betaxolol HCl, or maleic acid in organic solvent to give S-(−)-betaxolol maleate salt.