Patent ID: 8211918

Claim:
A compound of formula I where the dashed line represents an optional double bond; where R 1 is phenyl, naphthyl, pyridyl, pyrimidyl, pyrrolyl, imidazolyl, pyrazyl, furyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, or isothiazolyl, optionally substituted with one or two substituents selected independently from halogen, C 1 -C 6 alkyl, mono-halo C 1 -C 6 alkyl, di-halo C 1 -C 6 alkyl, CF 3 , CN, S—C 1 -C 6 alkyl, or O—C 1 -C 6 alkyl; R 2 is H, methyl, or halogen; R 3 and R 4 are, independently, CF 3 , OCF 3 , OC 1 -C 3 alkyl, halo or C 1 -C 3 alkyl, where the C 1 -C 3 alkyl groups are optionally substituted with one or more halogen atoms; X═O or S; Y is O or S; q=1 or 0; R 5 is C 1 -C 6 alkyl where the C 1 -C 6 alkyl group is optionally substituted with one or two groups selected, independently, from OH, OMe, OEt, F, CF 3 , Cl, or CN; (CHR 6 ) w C 3 -C 6 cycloalkyl, (CHR 6 ) w CH 2 C 3 -C 6 cycloalkyl, CH 2 (CHR 6 ) w C 3 -C 6 cycloalkyl, CR 6 ═CH—C 3 -C 6 cycloalkyl, CH═CR 6 —C 3 -C 6 cycloalkyl, (CHR 6 ) w C 5 -C 6 cycloalkenyl, CH 2 (CHR 6 ) w C 5 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Ar 1 , (CHR 6 ) w Ar 1 , CH 2 (CHR 6 ) w Ar 1 , or (CHR 6 ) w CH 2 Ar 1 , where w=0-3, Ar 1 is phenyl, pyridyl, pyrrolyl, thienyl, or furyl, and R 6 is hydrogen, methyl, halogen, or methoxy; where all cyclic groups are optionally substituted with one or two substituents selected independently from C 1 -C 3 alkyl, halogen, OH, OMe, SMe, CN, CH 2 F, and trifluoromethyl; or a pharmaceutically acceptable salt or ester thereof.