Patent ID: 8106207

Claim:
A compound of Formula (I): wherein R 1 is C 1-3 alkanyl; R 2 is C 1-3 alkanyl or hydrogen; R 3 is selected from the group consisting of hydrogen, C 1-8 alkanyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkanyloxy(C 1-8 )alkanyl, C 1-8 alkanylthio(C 1-8 )alkanyl, hydroxyC 1-8 alkanyl, thioformyl, phenylimino(C 1-8 )alkanyl, phenyl(C 1-8 )alkanyl, and heteroaryl(C 1-8 )alkanyl; wherein phenyl and heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkanyloxy and hydroxy; or optionally, when phenyl and heteroaryl are optionally substituted with two substituents attached to adjacent carbon atoms, the two substituents together form a single fused moiety; wherein the moiety is selected from —O(CH 2 ) 1-3 O—; R 4 is one to three substituents independently selected from the group consisting of hydrogen, C 1-6 alkanyl, C 1-6 alkanyloxy, C 1-6 alkanylaminocarbonyl, C 1-6 alkanylcarbonylamino, halogen, hydroxy, C 6-10 aryl, chromanyl, chromenyl, furanyl, imidazolyl, indazolyl, indolyl, indolinyl, isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, naphthyridinyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, quinolizinyl, quinoxalinyl, tetrazolyl, thiazolyl, and thiophenyl; R 5 is one to two substituents independently selected from the group consisting of hydrogen and halogen; A is absent; Y is O; Z is O; and enantiomers, diastereomers, tautomers, and pharmaceutically acceptable salts thereof.