Patent ID: 8592430

Claim:
A compound of general formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, or prodrug thereof, wherein: R1 is selected from hydrogen, halogen, hydroxyl, amino, thiol, C 1-6 alkoxy, C 1 -C 6 alkylthiol, C 1 -C 10 alkyl, C 1 -C 6 alkylamino, arylamino, aryl(C 1-6 alkyl)amino, aryl, heteroaryl, C 3 -C 7 cycloalkyl, or C 3 -C 7 heterocyclyl, any of which may optionally be substituted; R2 and R3 are each independently hydrogen, halogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 7 cycloalkyl, C 5 -C 7 cycloalkenyl, aryl, heteroaryl, or C 3 -C 7 heterocyclyl, any of which may optionally be substituted; R2 and R3 may also form a 3 to 6 membered Spiro ring system; and wherein one of R2 and R3 are hydrogen; R4, R5, R8 and R9 are each independently selected from hydrogen, halogen, C 1 -C 6 alkyl, —OR7, —SR7, —NR7R7′, —OC(O)R7′, —N(R7)C(O)R7′, or —N(R7)SO 2 R7′; R4 and R9 and/or R5 and R8 may also form a Spiro ring system; R7 and R7′ are each independently hydrogen, C 1-6 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, C 3 -C 7 cycloalkyl, C 5 -C 7 cycloalkenyl, aryl, heteroaryl, or C 3 -C 7 heterocyclyl, any of which may optionally be substituted; or when R4, R5, R8 or R9 is —OC(O)R7′, —N(R7)C(O)R7′, or —N(R7)SO 2 R7′, R7′ may additionally be NR10R11, where R10 and R11 are each independently hydrogen or C 1 -C 6 alkyl; and R6 is hydrogen, halogen, C 1-5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, C 3 -C 7 cycloalkyl, C 5 -C 7 cycloalkenyl, aryl, heteroaryl, or C 3 -C 7 heterocyclyl, any of which may optionally be substituted.