Patent ID: 7612179

Claim:
An isolated human, humanised or chimeric antibody or antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; (ii) binds to human plaques; and (iii) comprises: (a) a heavy chain CDR3 region comprising the sequence shown in SEQ ID NO: 26, SEQ ID NO: 20, SEQ ID NO: 23, SEQ ID NO: 207, SEQ ID NO: 208, SEQ ID NO: 209, SEQ ID NO: 210, or SEQ ID NO: 512; (b) a heavy chain CDR2 region comprising the sequence shown in SEQ ID NO: 25; (c) a heavy chain CDR1 region comprising the sequence shown in SEQ ID NO: 24; (d) a light chain CDR3 region comprising the sequence shown in SEQ ID NO: 35; (e) a light chain CDR2 region comprising the sequence shown in SEQ ID NO: 34; and (f) a light chain CDR1 region comprising the sequence shown in SEQ ID NO: 33.