Patent ID: 7384948

Claim:
A compound represented by the structural formula I or a pharmaceutically acceptable salt thereof; wherein: R 1 is R 2 is selected from the group consisting of H, alkyl, aryl, arylalkyl, heteroarylalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkylsulfonyl, arylsulfonyl, alkoxyalkyl, or amide; R 3 is selected from the group consisting of 6-membered heteroaryl, and 6-membered heteroaryl-N-oxide, wherein said 6-membered heteroaryl or heteroaryl-N-oxide is a pyrimidine or a pyrimidine-N-oxide respectively, each of which is optionally substituted with 1-4 substituents which can be the same or different and are independently selected from the group consisting of R 11 , R 12 , R 13 , R 14 and R 15 ; R 4 is 1-3-(C 1 -C 6 )alkyl-N(R 21 )SO 2 R 22 , wherein R 4 can be the same or different and is independently selected when there is more than one R 4 present; R 9 , R 10 and B can be the same or different and are each independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and —(C 1 -C 6 )haloalkyl; R 11 and R 12 can be the same or different and are each independently selected from the group consisting of (C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, halogen, —NR 19 R 20 , —OH, CF 3 , —OCH 3 , —O-acyl, and —OCF 3 ; R 13 is selected from the group consisting of hydrogen, R 11 , H, phenyl, —NO 2 , —CN, —CH 2 F, —CHF 2 , —CHO, —CH═NOR 19 , pyridyl-N-oxide, pyrimidinyl, pyrazinyl, N(R 20 )CONR 20 R 21 , —NHCONH(chloro-(C 1 -C 6 )alkyl), —NHCONH((C 3 -C 10 )-cycloalkyl(C 1 -C 6 )alkyl), —NHCO(C 1 -C 6 )alkyl, —NHCOCF 3 , —NHCOCF 3 , —NHSO 2 N((C 1 -C 6 )alkyl) 2 , —NHSO 2 (C 1 -C 6 )alkyl, —N(SO 2 CF 3 ) 2 , —NHCO 2 (C 1 -C 6 )alkyl, (C 3 -C 10 )cycloalkyl, —SR 22 , —SOR 22 , —SO 2 R 22 , —SO 2 NH(C 1 -C 6 alkyl), —OSO 2 (C 1 -C 6 )alkyl, —OSO 2 CF 3 , hydroxy(C 1 -C 6 )alkyl, —CONR 19 R 20 , —CON(CH 2 CH 2 —O—CH 3 ) 2 , —OCONH(C 1 -C 6 )alkyl, —CO 2 R 19 , —Si(CH 3 ) 3 and —B(OC(CH 3 ) 2 ) 2 ; R 14 is selected from the group consisting of (C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl —NH 2 and R 15 -phenyl; R 15 is 1-3 substituents selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —CF 3 , —CO 2 R 20 , —CN, (C 1 -C 6 )alkoxy and halogen; wherein R 15 can be the same or different and is independently selected when there are more than one R 15 present; R 19 , R 20 and R 21 can each be the same or different and are each independently selected from the group consisting of H, (C 1 -C 6 )alkyl and (C 3 -C 6 )cycloalkyl; R 22 is selected from the group consisting of (C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, (C 2 -C 6 )hydroxyalkyl, (C 2 -C 6 )alkylene, (C 3 -C 6 )cycloalkyl, aryl and aryl(C 1 -C 6 )alkyl-; A is selected from the group consisting of H, (C 1 -C 6 )alkyl, and (C 2 -C 6 ) alkenyl. M is aryl substituted with R 4 , wherein said aryl is phenyl; and Q is CH or N, with the following proviso: when R 1 is phenyl, R 2 cannot be H, —(C 1 -C 6 )alkyl or —C(O)—(C 1 -C 6 )alkyl.