Patent ID: 7426441

Claim:
A method for predicting the renal toxicity of a test compound, comprising: (a) preparing a normalized gene expression profile of at least ten genes for a rat kidney tissue or rat kidney cell sample, wherein the gene expression profile contains the differential gene expression values for said at least ten genes upon exposure to the test compound, and wherein said at least ten genes are listed in one of Tables 5-5CC; (b) comparing the gene expression profile to a renal toxicity model, the renal toxicity model comprising: (i) the normalized mean expression levels of said at least ten genes in kidney tissue or kidney cells exposed to a known renal toxin, and (ii) the normalized mean expression levels of said at least ten genes in unexposed kidney tissue or kidney cells; and (iii) information from one or more of Tables 5-5CC; (c) scoring the comparison to predict whether the test compound is a renal toxin; and (d) presenting the prediction.