Patent ID: 7867994

Claim:
A process for the synthesis of ivabradine, 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]-propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, of formula (I): and addition salts thereof with a pharmaceutically acceptable acid, wherein the compound of formula (V): wherein R 1 and R 2 , which may be the same or different, each represent linear or branched (C 1 -C 8 )alkoxy, is subjected to a catalytic hydrogenation reaction, and then the compound of formula (VI) thereby obtained: wherein R 1 and R 2 are as defined hereinbefore, is subjected to a reaction with the compound of formula (VII): wherein HX represents a pharmaceutically acceptable acid, in the presence of hydrogen and a catalyst, to yield directly, after filtering off the catalyst and isolation, the addition salt of ivabradine with the acid HX, which is optionally subjected, when it desired to obtain free ivabradine, to the action of a base.