Patent ID: 8026342

Claim:
An isolated humanized antibody, or an antigen binding fragment thereof, that binds sphingosine-1-phosphate and comprises at least one heavy chain and at least one light chain, wherein: A. each heavy chain comprises a heavy chain variable domain comprising a sequence of amino acid residues having an amino acid sequence [SEQ ID NO: 27] EVQLVQSGAEVKKPGESLKISCQSFGYIFIDHTIHWMR QMPGQGLEWMGAISPRHDITKYNEMFRGQVTISADK SSSTAYLQWSSLKASDTAMYFCARGGFYGSTIWFDF WGQGTMVTVSS; or and B. each light chain comprises a light chain variable domain comprising a sequence of amino acid residues having an amino acid sequence [SEQ ID NO: 29] ETTVTQSPSFLSASVGDRVTITCITTTDIDDDMNWFQQEPG KAPKLLISEGNILRPGVPSRFSSSGYGTDFTLTISKLQPEDF ATYYCLQSDNLPFTFGQGTKLEIK.