Patent ID: 7067488

Claim:
A GLP-1 peptide having the following formula, or a pharmaceutically acceptable salt thereof: X-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Y (SEQ ID NO.1) wherein: X is a rigidifying hydrophobic acyl moiety as obtained from the corresponding carboxylic acid of general structure I: wherein R1 is 2- or 3-lower alkoxy, 2- or 3-hydroxy, 2- or 3- amino, 2-N-phenylamino, 2,6-dihalo or 2,3,4,5,6-pentahalo and n=0 or 1, and Y is selected from the group consisting of OH, NH 2 and Gly-OH.