Patent ID: 8710074

Claim:
A compound having a structure represented by a formula: wherein one of Y 1 and Y 2 is N, and the other is C—R 3a ; wherein Y 3 is O, N—R 7 , or a covalent bond; wherein one of L 1 and L 2 is —O—, and the other is —C(R 1a , R 1b )—; provided that when Y 1 is N, L 1 is —O— and L 2 is —C(R 1a R 1b )—; wherein Ar 1 is phenyl with 0-3 substituents selected from halogen, cyano, C1-C4 alkyl, and C1-C4 alkyloxy, or Ar 1 is monocyclic heteroaryl having 0-3 substituents selected from halogen, cyano, C1-C4 alkyl, and C1-C4 alkyloxy; wherein each of R 1a and R 1b is independently selected from hydrogen and C1-C4 alkyl; wherein R 2 is selected from hydrogen; C1-C6 alkyl; (C1-C6 alkyloxy) C1-C6 alkyl; C3-C8 cycloalkyl; (C3-C8 cycloalkyl) C1-C6 alkyl; C2-C5 heterocyclyl; phenyl with 0-3 substituents selected from halogen, cyano, C1-C4 alkyl, and C1-C4 alkyloxy; and monocyclic heteroaryl having 0-3 substituents selected from halogen, cyano, C1-C4 alkyl, and C1-C4 alkyloxy; wherein R 3a is selected from hydrogen, halogen, cyano, and C1-C4 alkyl; wherein R 3b is selected from hydrogen, halogen, cyano, and C1-C4 alkyl, or R 3a and R 3b are substituted on adjacent carbons and are covalently bonded and, together with the intermediate carbons, comprise an optionally substituted fused ring selected from 4- to 7-membered cycloalkenyl, 5- to 7-membered heteroaryl, and 6-membered aryl; wherein R 4a and R 4b are independently selected from hydrogen and C1-C4 alkyl, or R 4a and R 4b are covalently bonded and, together with the intermediate carbon, comprise an optionally substituted 3- to 7-membered spirocycloalkyl; wherein R 5a and R 5b are independently selected from hydrogen and C1-C4 alkyl; or R 5a and R 5b are covalently bonded and, together with the intermediate carbon, comprise an optionally substituted 3- to 7-membered spirocycloalkyl; or R 4a and R 5a are optionally covalently bonded and, together with the intermediate atoms, comprise an optionally substituted 3- to 7-membered fused cycloalkyl; wherein R 6a and R 6b are independently selected from hydrogen and C1-C4 alkyl, or R 6a and R 6b together comprise an exocyclic double bond, or R 6a and R 6b arecovalently bonded and, together with the intermediate carbon, comprise cyclopropyl; and wherein R 7 is selected from hydrogen and C1-C6 alkyl; and or a pharmaceutically acceptable salt, hydrate, solvate, or polymorph thereof.