Patent ID: 8609633

Claim:
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T comprising administering, to a patient having a condition involving detrimental activity of the enzyme core 2 GlcNAc-T selected from the group consisting of vascular diseases, autoimmune and inflammatory conditions, a therapeutically effective amount of an inhibitor of core 2 GlcNAc-T of formula I to a patient in need thereof wherein: R 1 is H, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy or C 1-6 -alkoxy-C 1-6 -alkyl; R 2 is H, —OH or C 1-6 alkoxy; Sac 1 and Sac 2 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof.