Patent ID: 6841533

Claim:
A backbone cyclized peptide analog having IL-6 antagonist activity, having the general formula 3: wherein m and n are 1 to 5; X designates a terminal carboxy acid, amide or alcohol group; R 1 is (D)Bip, Gln, Lys, Lys(ZCL) or Dab; R 2 is (D)Lys, Gly, Ala or Trp R 3 is Orn, 4PyrAla, (L) or (D)Dab, (D)Arg, Lys or Dpr; R 4 is Lys, Lys(ZCL), Arg, Arg(Mtr) or (D)Glu; R 5 is Asn, Trp or (D)Ala; R 6 is Arg, (p-NO 2 )Phe, (L) or (D)Trp, Gln, Abu or Glu; and Y 2 is amide, thioether, thioester or disulfide.