Patent ID: 7727730

Claim:
A kit for measuring aspirin responsiveness by detecting 11-dehydro thromboxane B 2 and 11-dehydro-2,3-dinor thromboxane B 2 in a urine sample from a subject treated with aspirin, the kit comprising: a monoclonal antibody selectively produced to bind 11-dehydro thromboxane B 2 and 11-dehydro-2,3-dinor thromboxane B 2 ; and a signal molecule capable of competing with 11-dehydro thromboxane B 2 and 11-dehydro-2,3-dinor thromboxane B 2 in the urine sample for binding to the monoclonal antibody; wherein the 11-dehydro thromboxane B 2 and 11-dehydro-2,3-dinor thromboxane B 2 in the subject's urine sample competes with a known amount of signal molecule for binding to the monoclonal antibody thereby indicating the amount of the 11-dehydro thromboxane B 2 and 11-dehydro-2,3-dinor thromboxane B 2 in the urine, and wherein response to aspirin shows a decreased amount of 11-dehydro thromboxane B 2 and 11-dehydro-2,3-dinor thromboxane B 2 in the subject's urine relative to a standard and/or the amount in the urine from same subject or a different subject not treated with aspirin.