Patent ID: 8426447

Claim:
A compound of Formula I: or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A 1 is CR 6 ; A 2 is CR 5 ; A 3 is CR 4 or N; A 4 is CR 3 or N; A 5 is CR 1 or N; A 6 is CR 8 ; T 1 is CR 2 ; T 2 is CR 7 , provided that (1) no more than two of A 3 , A 4 and A 5 , is N, such that the fused ring comprising A 3 , A 4 , A 5 and T 1 form a fused benzene, pyridine or pyridazine ring; each of R 1 , R 4 , R 5 and R 8 , independently, is H, F, Cl, Br, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl or —C(O)C 1-6 -alkyl, wherein the C 1-6 -alkyl and C 1-6 -alkyl portion of —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl and —C(O)C 1-6 -alkyl are optionally substituted with 1-3 substituents of F, oxo or OH; each of R 2 and R 7 , independently, is H, halo, haloalkyl, haloalkoxyl, C 1-6 -alkyl, C 2-6 alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 4-8 -cycloalkenyl, CN, OR 10 , SR 10 , NR 10 R 10 , C(O)R 10 , S(O)R 10 , S(O) 2 R 10 , NR 10 C(O)R 10 , C(O)NR 10 R 10 , NR 10 S(O) 2 R 10 , S(O) 2 NR 10 , NR 10 C(O)NR 10 R 10 , or a fully saturated or partially or fully unsaturated 4-, 5-, 6- or 7-membered monocyclic or 9- or 10-membered bicyclic ring formed of carbon atoms, said ring optionally including 1-4 heteroatoms selected from O, N, or S, wherein the C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 4-8 -cycloalkenyl and ring are optionally substituted, independently, with 1-5 substituents of R 9 or R 10 ; each of R 3 and R 6 , independently, is H, halo, haloalkyl, haloalkoxyl, C 1-6 -alkyl, CN, OH, OC 1-6 -alkyl, S(O) o C 1-6 -alkyl, NHC 1-6 -alkyl or C(O)C 1-6 -alkyl; each R 9 , independently, is —C(O)R 10 , —S(O) 2 R 10 , —C(O)NHR 10 , —NHC(O)R 10 , —NHC(O)NHR 10 , —S(O) 2 NHR 10 or —NHS(O) 2 R 10 ; each R 10 , independently, is H, halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, oxo, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkenyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a fully saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, haloalkoxyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -thioalkoxyl, benzyl or phenyl; W is CR 1 R 1 ; X is O; Y is O; and Z is absent.