Patent ID: 8765135

Claim:
An aqueous immunogenic composition which, after administration to a subject, is able to induce an immune response that is bactericidal against serogroups B, C, W135 and Y of N. meningitidis , wherein the composition comprises: (i) a conjugated serogroup C capsular saccharide antigen; (ii) a conjugated serogroup W135 capsular saccharide antigen; (iii) a conjugated serogroup Y capsular saccharide antigen; and (iv) a ‘NadA’ protein in oligomeric form, a ‘741’ protein, a ‘936’ protein, a ‘953’ protein and a ‘287” protein, wherein: the NadA has an amino acid sequence which has 80% or more identity to SEQ ID NO:2; the 741 has an amino acid sequence which has 80% or more identity to SEQ ID NO:3; the 936 has an amino acid sequence which has 80% or more identity to SEQ ID NO:4; and (a) the 953 has an amino acid sequence which has 80% or more identity to SEQ ID NO:5; and the 287 has an amino acid sequence which has 80% or more identity to SEQ ID NO:6; or (b) the 953 and the 287 form a contiguous polypeptide having an amino acid sequence which has 80% or more identity to SEQ ID NO: 7.