Patent ID: 8063104

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R 1 is -L-Het-L′, -L-Y-L′, -L-Het-A or -L-Y-A; wherein: L is C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; L′ is C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; A is C 6 -C 10 aryl, C 3 -C 8 carbocyclyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl; Het is —O—, —S— or —NR′—, wherein R′ is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; Y is —CO—, —SO—, —SO 2 —, —CO—O—, —CO—NR′—, —O—CO— or —NR′-CO—, wherein R′ is defined as above; R 2 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; and R 3 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; R 4 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; B is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, —O-L-, —S-L- or -L-Het-L′-; wherein L, L′ and Het are as defined above; X is —O—, —S— or —NR'-; wherein R′ is as defined above; R 5 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl, C 3 -C 8 carbocyclyl, 5- to 10-membered heterocyclyl, 5- to 10-membered heteroaryl, -L-A, -L-Het-L′, -L-Y-L′, -L-Het-A, -L-Y-A, -L-A-Het-A, -L-A-L′-A or -L-A-Het-L′-A; wherein L, L′, Het and Y are as defined above and wherein each A is the same or different and is as defined above; R 6 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; R 7 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; and R 8 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; wherein: the alkyl, alkenyl and alkynyl groups and moieties in the substituents R 1 to R 7 , X and B are unsubstituted or substituted by one, two or three substituents which are the same or different and are independently selected from the group consisting of halogen, hydroxy, amino and thio substituents; and the aryl, carbocyclyl, heterocyclyl and heteroaryl groups and moieties in the substituents R 1 and R 5 are unsubstituted or substituted by one, two or three substituents independently-selected from the group consisting of halogen, hydroxy, amino, thio, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, nitro, cyano, C 1 -C 6 alkylamino, di-(C 1 -C 6 alkyl)amino, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy and C 1 -C 6 haloalkylthio substituents.