Patent ID: 8501727

Claim:
A pharmaceutical composition comprising a compound having a structure according the following formula or a pharmaceutically acceptable addition salt thereof, wherein each linker a, b, c, d, and e is, independently, CH 2 , O, S, or a single bond; linker f is C(O) or a single bond; each R 1 , R 2 , R 3 , R 4 , and R 5 is, independently, H, F, Cl, Br, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxyalkyl, or CO 2 R 9 ; each R 6 and R 7 is, independently, H, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkoxyalkyl; R 8 is H, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted lower alkoxyalkyl; R 9 is substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl; n is 2, 3, or 4, where any combination of 0, 1, or 2 methyl or ethyl groups in total can be substituted on any of the methylene groups in the chain; and wherein when any R 1 , R 2 , R 3 , R 4 , or R 5 is H, F, Cl, or Br, the corresponding linker is a single bond; and at least one of a-R 1 , b-R 2 , c-R 3 , d-R 4 , or e-R 5 is (single bond)-CO 2 R 9 or at least one of a-R 1 , b-R 2 , c-R 3 , d-R 4 , or e-R 5 is O-(lower alkyl substituted with CO 2 R 9 ), or at least one of a-R 1 , b-R 2 , c-R 3 , d-R 4 , or e-R 5 is O-(lower alkoxyalkyl substituted with CO 2 R 9 ).