Patent ID: 8772254

Claim:
A method for delivering a double-stranded RNA molecule to a pest species, comprising co-expressing in a plant cell of: a) an RNA delivery molecule consisting of a polypeptide sequence comprising i) at least one sequence-specific RNA-binding domain, ii) at least one targeting polypeptide, able to bind to a cellular endocytosis and/or transcytosis receptor molecule, and iii) optionally at least one peptide linker for linking the sequence-specific RNA binding domain (i) to the targeting polypeptide (ii), and b) an RNA molecule which comprises double-stranded RNA comprising annealed complementary strands, one of which has a nucleotide sequence which is complementary to at least part of a target nucleotide sequence of a target gene of a pest species, and which further comprises a nucleotide sequence which specifically binds to the sequence-specific RNA-binding domain of the RNA delivery molecule of (a); and feeding said plant cell to said pest species.