Patent ID: 8921363

Claim:
A compound of Formula I: or a stereoisomer, tautomer, hydrate, solvate or pharmaceutically acceptable salt thereof, wherein A 1 is CH; A 2 is CH; A 3 is CR 4 or N; A 4 is CR 3 or N; A 5 is CH; A 6 is CH, provided that no more than one of A 3 and A 4 , is N; R 2 is Cl, Br, C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NH-phenyl, —NH-benzyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl, cyclohexyl or —Si(CH 3 ) 3 , wherein the C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NH-phenyl, —NH-benzyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl and cyclohexyl are optionally substituted, independently, with 1-3 substituents of R 9 ; R 3 is H, F, Cl, Br, CF 3 OCF 3 CH 3 or CN; R 4 is H, F, Cl, Br, CF 3 OCF 3 CH 3 or CN; R 7 is a ring selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, said ring optionally substituted, independently, with 1-3 substituents of R 9 ; each R 9 , independently, is halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, —C(O)NHCH 3 , oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, each of W, X, Y and Z, independently, is CR 10 or N, wherein each R 10 , independently, is H, F, Cl, Br, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, provided that no more than one of W, X, Y and Z are N.