Patent ID: 6902735

Claim:
An antibody that specifically reacts with a protein comprising an amino acid sequence selected from the group consisting of: (a) the amino acid sequence of SEQ ID NO:2; (b) the amino acid sequence of SEQ ID NO:2 from amino acids 11 to 163; (c) the amino acid sequence of SEQ ID NO:2 from amino acids 29 to 163; (d) the amino acid sequence of SEQ ID NO:2 from amino acids 31 to 163; and (e) a fragment of the amino acid sequence of SEQ ID NO:2 having at least one CTLA-8 activity selected from the group consisting of induction of expression or secretion of γ-IFN, induction of expression or secretion of IL-6, induction of expression or secretion of IL-8, and inhibition of angiogenesis.