Patent ID: 8338450

Claim:
Compounds of the general formula A in exo configuration, their optical isomers and pharmaceutically acceptable salts thereof, wherein, n=1, 2 Y is selected from the groups wherein, Z represents CH 2 ,—S—, CHF; R 1 is selected from groups consisting of i) Hydrogen; ii) C 1 -C 8 alkyl (straight or branched) substituted with 1 to 3 substituents selected from halogens, such as pentyl, trifluoropropyl; iii) cycloalkyl or cycloalkenyl having 3-10 carbon atoms such as cyclohexyl or cyclohex-2-enyl; iv) cycloalkylmethyl having 4-10 carbon atoms such as cyclohexyl methyl; v) Bridged polycycloalkyl methyl having 5 to 12 carbon atoms such as adamantyl methyl; vi) phenyl which is unsubstituted or substituted with 1-3 substituents each independently selected from cyano or methanesulfonyl; vii) aralkyl group such as benzyl which is unsubstituted or substituted with 1 to 3 substituents selected from halogens; viii) heteroaryl group such as pyridyl substituted with cyano; ix) heteroaralkyl group such as pyridyl methyl; x) aralkoxyalkyl group such as benzyloxy ethyl; xi) SO 2 R 5 ; where R 5 is methyl, thiophenyl, or phenyl unsubstituted or substituted with 1 to 3 fluoro; xii) —CONHR 6 or —CSNHR 6 or —CONHSO 2 R 6 ; where R 6 is phenyl unsubstituted or substituted with chloro, fluoro, trifluoromethyl or methoxy; xiii) R 7 CO—, wherein R 7 is selected from a. unsubstituted phenyl or substituted with 1 to 3 substituents selected from halogen, trifluoromethyl, cyano; b. benzo[1,3]dioxolyl; c. adamantyl; d. heteroaryl such as thiophenyl; furyl; pyrazinyl; pyridyl unsubstituted or substituted with a substituent selected from halogen, cyano, methyl, benzyloxy; e. N-acetylpiperidinyl; f. Cyclohexyl; g. Pyridine methyl; R 2 is selected from hydrogen, CN, COOH, or isosteres of COOH, wherein said isosteres of COOH are selected from the groups consisting of esters, tetrazole, acid anhydrides, CH 2 OH, CH 2 OBn, CONHOH, CONH 2 ; R 3 is selected from hydrogen, —CN, C 2 -C 5 alkynyl; R 4 is selected from hydrogen or fluoro.