Patent ID: 8409549

Claim:
An aerosol formulation for the treatment of infection caused by bacteria in the respiratory tract of a patient said formulation comprising from about 1 mg to about 300 mg of fosfomycin, about 1 mg to about 300 mg of tobramycin, and about 0.5-7 mL of a physiologically suitable solution containing a chloride concentration >30 mM; wherein said formulation is to be administered by aerosolization using a nebulizer able to produce an aerosol with a predominant particle size distribution between 1 and 5 μm and wherein the weight ratio of fosfomycin to tobramycin is selected from the group consisting of: (i) from about 7 parts by weight of fosfomycin to about 3 parts by weight of tobramycin; (ii) from about 8 parts by weight of fosfomycin to about 2 parts by weight of tobramycin; and (iii) from about 9 parts by weight of fosfomycin to about 1 part by weight of tobramycin.