Patent ID: 7179817

Claim:
A pharmaceutical composition comprising a carboxylic acid compound represented by formula (I) wherein R 1 is C1–8 alkyl, C1–8 alkoxy, halogen atom, nitro or trifluoromethyl, ring A is C5–7 mono-carbocyclic ring or 5–7 membered mono-cyclic hetero ring containing 1–2 nitrogen atoms, one oxygen atom and/or one sulfur atom, E is —CH 2 —, —O—, —S— or —NR 6 — (wherein R 6 is hydrogen or C1–8 alkyl), R 2 is C1–8 alkyl, C1–8 alkoxy, halogen atom, nitro or trifluoromethyl, R 3 is hydrogen or C1–8 alkyl, R 4 is hydrogen or C1–8 alkyl, or R 2 and R 4 taken together form —CH 2 —CH 2 — or —CH═CH—, G is —CONR 7 —, —NR 7 CO—, —SO 2 NR 7 —, —NR 7 SO 2 —, —CH 2 NR 7 — or —NR 7 CH 2 — (wherein R 7 is hydrogen, C1–8 alkyl, Cyc1 or C1–8 alkyl substituted by Cyc1, Cyc1 is C5–7 mono-carbocyclic ring or 5–7 membered mono-cyclic hetero ring containing 1–2 nitrogen atoms, one oxygen atom and/or one sulfur atom.), Q is C1–4 alkylene or J 1 , J 2 , J 3 and J 4 are each independently carbon atom or nitrogen atom (with the proviso that the number of nitrogen is less than two), R 5 is (1) C1–8 alkyl, (2) halogen atom, (3) nitro, (4) cyano, (5) trifluoromethyl, (6) trifluoromethoxy, (7) phenyl, (8) tetrazolyl, (9) —OR 9 , (10) —SR 10 , (11) —COOR 11 , (12) —NR 12 R 13 , (13)—CONR 14 R 15 , (14) —SO 2 NR 16 R 17 , (15) —NR 18 COR 19 , (16) —NR 20 SO 2 R 21 , (17) —SO 2 R 22 or (18)—OP(O)(OR 23 ) 2 , (wherein R 9 -R 18 , R 20 and R 23 are each independently hydrogen, C1–8 alkyl, Cyc2 or C1–8 alkyl substituted by Cyc2, R 12 and R 13 , R 14 and R 15 , R 16 and R 17 together with nitrogen atom to which they are attached, form 5–7 membered mono-cyclic hetero ring containing 1–2 nitrogen atoms, one oxygen atom and/or one sulfur atom (the hetero ring may be optionally substituted by C1–8 alkyl, hydroxy or amino) R 19 and R 21 are each independently C1–8 alkyl, Cyc2 or C1–8 alkyl substituted by Cyc2, R 22 is hydroxy, C1–8 alkyl, Cyc2 or C1–8 alkyl substituted by Cyc2, Cyc2 is C5–7 mono-carbocyclic ring or 5–7 membered mono-cyclic hetero ring containing 1–2 nitrogen atoms, one oxygen atom and/or one sulfur atom), wherein, when Q is and J 2 is carbon atom substituted by R 5 , G may be (wherein U is oxygen atom, nitrogen atom or sulfur atom, W is carbon atom or nitrogen atom, R 8 and R 5 , which bonds J 2 , taken together form bond, carbon atom or nitrogen atom), p is 0 or an integer of 1–5, q is an integer of 4–6, r is 0 or an integer of 1–4, s is 0 or an integer of 1–4, and is single bond or double bond, a prodrug thereof or a non-toxic salt thereof, wherein said prodrug has a carboxylate ester, a carboxylic amide or an alcohol in place of —COOH in formula (I), and a pharmaceutically acceptable carrier or diluent.