Patent ID: 8486892

Claim:
A compound of general formula (I) X 1 -X 2 -X 3 -X 4 -X 5 -(X 6 ) n -(X 7 ) m -Y (I) wherein X 1 represents lower alkoxycarbonyl, lower alkenyloxycarbonyl, alkynyloxycarbonyl, cycloalkyloxycarbonyl, cycloalkylalkyloxycarbonyl, aryloxycarbonyl, arylalkyloxycarbonyl, or heteroarylalkyloxycarbonyl, lower alkylaminocarbonyl, lower alkenylaminocarbonyl, alkynylaminocarbonyl, cycloalkylaminocarbonyl, cycloalkylalkylaminocarbonyl, arylaminocarbonyl, arylalkylaminocarbonyl, or heteroarylalkylaminocarbonyl, lower alkanoyl, lower alkenoyl, lower alkadienyl, alkynoyl, cycloalkanoyl, cycloalkylalkanoyl, cycloalkenylalkanoyl, aroyl, arylalkanoyl, or heteroarylalkanoyl, wherein said groups are optionally substituted with halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkylthio, or cyano; X 2 represents 4-amidino-Phe, Arg, HomoArg, Orn, Lys, Dab, or Dap; X 3 represents Glu, Asp, (α-Me)Glu, 1-aminocyclobutane-trans-1,3-dicarboxylic acid, or 1-aminocyclobutane-cis-1,3-dicarboxylic acid; X 4 represents Arg, HomoArg, Lys, H is, Asn, Gln, Trp, Phe, Phg, Glu, D-Glu, Asp, D-Asp, Dab, Dap, Nβ-[amidino]-Dap, or Nγ-[amidino]Dab; X 5 represents Phg, D-Phg, Phe, Val, Ile, Leu, Lys, Ala, Glu, Gly, Aib, Trp, Abu, Alle, Cha, Hph, Nle, or Nva; X 6 represents Arg, HomoArg, Lys, Orn, H is or Lys(mPeg(1-10k)-CO); X 7 represents a diradical of general formula —HN—(CH 2 —CH 2 —O) 1-10 —(CH 2 ) 1-5 —C(═O)—; Y represents NH 2 or OH; and n is 0 or 3-6 and m is 0-20, with the proviso that n and m must not be zero simultaneously, including any and all stereoisomeric form or forms thereof, any mixture of two or more such compounds of formula I in any ratio, and physiologically acceptable salts thereof.