Patent ID: 7176237

Claim:
A compound having the formula: wherein R 1 is CN, or CO 2 H; R 2 is ═O; R 3 is H, CH 3 , CO 2 H, CO 2 Me, CONH 2 , CN, or (CH 2 ) n —R 10 ; R 4 is H, OH, OAc, CH 3 , CO 2 H, CO 2 Me, CONH 2 , CN, or (CH 2 ) n —R 10 ; R 5 is H, CH 2 , CH 2 CH 3 , or part of a double-bond A; R 6 is H, CH 3 , CO 2 H, CO 2 Me, CONH 2 , CN, CH 2 X, CH 2 OAc, CH 2 OH, CHO, CH 2 NH 2 , (CH 2 ) n —R 10 , CO 2 R, CH 2 OR, CH 2 OSiMe 2 (t-Bu), CONR 1 R 2 , CH 2 NHCOOR, or CH 2 NHCOO(t-Bu); R 7 is H, ═O; R 8 is H, OH, forms an epoxide with R 9 ; or forms part of double-bond B; R 9 is H, forms an epoxide with R 8 , or forms part of double-bond B; R 10 is CH 3 , CO 2 H, CO 2 CH 3 , CO 2 CH 2 CH 3 , CONH 2 , CN, NH 2 , CH(CH 3 ) 2 , NR 11 R 12 , pyrrolidine, piperidine, pyrazine, imidazole, pyrazole, triazole, tetrazole, substituted at N with R 13 , or 1,4-oxazine, where R 11 , R 12 , and R 13 are alkyl; X is F, Cl, or Br; n is 0–20; and A & B independently signifies a single- or double-bond; or an optically active form (−)-, (+)-, thereof, or a (±) racemic form thereof; or a pharmaceutically acceptable salt or formulation thereof.