Patent ID: 8563732

Claim:
A compound having the Formula I: or a pharmaceutically acceptable salt, thereof wherein: Y is CO or SO m ; Z is optionally substituted aryl or optionally substituted heterocyclyl; R 1 and R 2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heterocyclyl, cyano, COR 5 , or CONR 5 R 6 , or R 1 and R 2 taken together, with the carbon atom to which they are attached, form optionally substituted cycloalkyl, optionally substituted bicycloalkyl, optionally substituted cycloalkenyl or optionally substituted heterocyclyl; R 5 and R 6 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted bicycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; each X is independently ═O, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, halogen, cyano, nitro, NR 5 R 6 , OR 5 , SR 5 , COR 5 , COOR 5 , CONR 5 R 6 , NR 5 COR 5 , OCOR 5 , SOR 5 , SO 2 R 5 , SO 3 R 5 , SONR 5 R 6 , SO 2 NR 5 R 6 , NR 5 SOR 5 , or NR 5 SO 2 R 5 ; m is 1 or 2; and p is 0, 1 or 2; provided that: when R 1 is aminothiazolyl, R 2 is CONHR 6 , wherein R 6 is optionally substituted heterocyclyl and Y is CO, then Z is not 4-nitrobenzyloxy.