Patent ID: 8808699

Claim:
A method for enhancing an immune response against a Staphylococcus aureus bacterium in a subject comprising: (a) providing to the subject a composition comprising an isolated antibody that specifically binds to a nontoxigenic Staphylococcus aureus Protein A (SpA) epitope SpA KKAA ; and (b) providing to the subject a staphylococcal antigen, wherein the antigen is selected from the group consisting of: FnBpA, FnBpB, LukD, LukE, LukF, SasA, SasD, SasG, SasI, SasK, SpA variant, Eap, Ebh, Emp, EsaB, EsaC, EsxA, EsxB, SdrC, SdrD, SdrE, IsdA, IsdB, ClfA, ClfB, Coa, Hla, IsdC, SasF, vWbp, and vWh; wherein the antibody enhances an immune response against a Staphylococcus aureus antigen.