Patent ID: 7220856

Claim:
A compound of formula (3a): or an enantiomer, a diastereomer, a salt or a solvate thereof, wherein: R 1 is hydrogen or amino; R 2 is halogen; R 3 is hydrogen, alkyl, halogenated alkyl, halogen, substituted or unsubstituted amino, nitro, cyano, or alkoxy; R 4 is hydrogen or one or more alkyl groups; R 1a is oxo or thioxo; R 2a and R 3a are independently hydrogen, oxo, or thioxo; or, when bonded to adjacent ring carbon atoms, R 2a and R 3a may combine to form a fused aryl or heterocyclyl ring; R 25 is (i) hydrogen, or cyano; (ii) alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aryl, or arylalkyl, any of which may be optionally independently substituted with one to three halogen, alkoxy, hydroxy, alkyl, or haloalkyl; or (iii) —(CR 20 R 21 ) m —C(═O)R 15 , —(CR 20 R 21 ) m —C(═O)OR 15 , —(CR 20 R 21 ) m —SO 2 R 15a , —(CR 20 R 21 ) m —C(═O)NR 16 R 17 , —(CR 20 R 21 ) m —C(═S)NR 16 R 17 ; or —(CR 20 R 21 ) m —C(═O)NR 16 —SO 2 R 15b ; R 15 is hydrogen, alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, aryloxyalkyl; R 15a is hydrogen, alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, aryloxyalkyl provided that when m is zero R 15a is not hydrogen; R 15b is alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, aryloxyalkyl; R 16 and R 17 are independently hydrogen, alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aryl, or arylalkyl; or R 16 and R 17 together with the nitrogen atom to which they are bonded may combine to form a heterocyclyl ring; R 20 and R 21 at each occurrence are the same or different and are independently selected from hydrogen or alkyl; X is O or X; Z is —S—, —S(O)— or —S(O) 2 —; p is 1 or 2; p* is 0, 1, 2, 3 or 4; q is 0 or 1; and m is 0, 1 or 2.