Patent ID: 7977368

Claim:
Compounds of the formula: stereoisomers, tautomers, mixtures of stereoisomers and/or tautomers or pharmaceutically acceptable salts thereof, wherein A is C 1 -C 6 alkyl, aryl, C 3 -C 6 cycloalkyl, heteroaryl or heterocyclyl, wherein each ring is optionally substituted at a substitutable position with one or more of halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, hydroxyalkyl, CN, aryloxy, arylalkyloxy, —SO 2 —(C 1 -C 6 alkyl), —NR′R″, C 1 -C 6 alkanoyl, C 0 -C 3 alkyl-C(O)OR′, heteroaryl, heterocyclyl, aryl, arylalkyl, or —SO 2 —NR′R″, and wherein when A is C 1 -C 6 alkyl, the C 1 -C 6 alkyl group is optionally substituted at a substitutable position with one or more of halogen, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, C 1 -C 6 haloalkoxy, hydroxyl, hydroxyalkyl, CN, aryloxy, arylalkyloxy, —SO 2 —(C 1 -C 6 alkyl), —NR′R″, C 1 -C 6 alkanoyl, C 0 -C 3 alkyl-C(O)OR′, heteroaryl, heterocyclyl, aryl, arylalkyl, or —SO 2 —NR′R″, R 1 , R 1a , R 2 , and R 2a , are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkylC 1 -C 6 alkyl, C 1 -C 6 haloalkyl, aryl, arylC 1 -C 6 alkyl, heteroaryl, heterocyclyl, —C(O)OR′, —CONR′R″, C 1 -C 4 haloalkoxyalkyl, hydroxy C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkanoyl, aryloxyC 1 -C 6 alkyl, heteroaryloxy C 1 -C 6 alkyl, —C 0 -C 6 alkyl-OC(O)NR′R″, —C 0 -C 6 alkyl-NR′R″, hydroxyl, CN, or —C 0 -C 6 alkyl-OC(O)-heterocyclyl, wherein each aryl, heteroaryl, and heterocyclyl group is optionally substituted with one or more groups that are independently halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkanoyl, halo C 1 -C 4 alkyl, halo C 1 -C 4 alkoxy, —C(O)NR′R″, —NR′R″, hydroxyl, CN, or —C(O)OR′; or R 1 and R 1a , or R 2 and R 2a together with the carbon to which they are attached form C 3 -C 6 cycloalkyl group wherein one of the carbons is optionally replaced with a heteroatom selected from N, O or S and wherein said ring may be optionally substituted with C 1 -C 6 alkyl; or R 1 and R 1a , or R 2 and R 2a together with the carbon to which they are attached form an oxo group; R′ and R″ are independently H or C 1 -C 6 alkyl; or R′ and R″ together with the atom to which they are attached may form a 3-8 membered ring optionally including an additional heteroatom such as N, O or S; Y is —SO 2 —, —SO 2 —O— or S0 2 -NR 10 —; and R 10 is H or C 1 -C 6 alkyl.