Patent ID: 8837674

Claim:
A method of minimizing radiation toxicity in image guided radiotherapy (IGRT), comprising: a. using a hybrid online data acquisition system to monitor a geometry and a topology of a treatment region from a non-radiation modality, a radiation modality, or said non-radiation modality and said radiation modality; b. using a probabilistic prediction algorithm operating on a suitably programmed computer to process a real-time multimodality input from said online data acquisition system, wherein said probabilistic prediction algorithm provides real-time geometric and topological target estimates to compensate for a latency of said online data acquisition system; c. using an online adaptive imaging system, wherein online adaptive imaging of said online adaptive imaging system is used to obtain radiographic images of a target when said real-time geometric and topological target estimates are in a region of predefined uncertainty; and d. using an image dose control algorithm operating on said suitably programmed computer to obtain real-time parameters to control a dose per image, wherein instances for image acquisition are optimized according to a planned dose pattern and delivery result according to said real-time geometric and topological target estimates, said predefined uncertainty, said planned dose pattern and accumulative delivery results at a processing instance.