Patent ID: 8138146

Claim:
A method for suppressing multiplication of a virus, comprising: administering a peptide to a subject in need thereof, wherein said peptide contains a first segment and a second segment; wherein said first segment is composed of at least five contiguous amino acid residues of a nuclear localization sequence (NLS), or a modified amino acid sequence of the NLS in which a single basic amino acid residue has been replaced with another basic amino acid residue, or a single hydrophobic amino acid residue has been replaced with another hydrophobic amino acid residue, or a modified amino acid sequence of the NLS in which two or three basic amino acid residues have each been replaced with another basic amino acid residue, or in which two or three hydrophobic amino acid residues have each been replaced with another hydrophobic amino acid residue, and wherein said second segment is composed of at least five contiguous amino acid residues of a nuclear export signal sequence (NES), or a modified amino acid sequence of the NES in which a single basic amino acid residue has been replaced with another basic amino acid residue, or a single hydrophobic amino acid residue has been replaced with another hydrophobic amino acid residue, or a modified amino acid sequence of the NES in which two or three basic amino acid residues have each been replaced with another basic amino acid residue, or in which two or three hydrophobic amino acid residues have each been replaced with another hydrophobic amino acid residue.