Patent ID: 8198071

Claim:
A method for manufacturing a biochip including: preparing a base plate; forming a metallic membrane on the base plate; forming a crosslinkable polymer membrane on the metallic membrane; selectively removing portions of the polymer membrane; delineating a plurality of wells reaching the base plate in the metallic membrane by using the polymer membrane as an etching mask; introducing a plurality of hydroxyl groups on a surface of the base plate exposed from the plurality of wells; bonding a plurality of probe biomolecules including protected amino groups to the plurality of hydroxyl groups; and soaking the base plate, the metallic membrane and the polymer membrane in an alkaline solution to deprotect the amino groups included in the plurality of probe biomolecules and peel off the polymer membrane from the metallic membrane after the probe biomolecules are introduced on the base plate, wherein the crosslinkable polymer membrane protects the metallic membrane while the probe biomolecules are introduced on the plate exposed from the plurality of wells.