Patent ID: 7276502

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are each independently R, halogen, CN, NO 2 , or TR; T is an optionally substituted C 1 -C 4 alkylidene chain wherein up to two methylene units of T are optionally and independently replaced by O, N(R), C(O), S, SO, or SO 2 ; Ar 1 is wherein each occurrence of QR 5 is, independently, CH 2 halogen, halogen, CH 2 CN, CN, CH 2 CO 2 R′, CO 2 R′, CH 2 COR′, COR′, R′, CH 2 NO 2 , NO 2 , CH 2 OR′, OR′, CH 2 SR′, SR′, haloalkyl, CH 2 SO 2 N(R′) 2 , SO 2 N(R′) 2 , CH 2 N(R′) 2 , N(R′) 2 , NHCOR′, CH 2 NHCOR′, CH 2 PO(OR′) 2 , PO(OR′) 2 ; R 3 and R 4 are each independently Z-R 7 , or R 3 and R 4 are taken together to form an optionally substituted saturated, partially unsaturated, or fully unsaturated 3-8 membered ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur wherein said ring is optionally substituted with 0-5 independent occurrences of Y-R 8 ; each occurrence of Q, Z, and Y is independently a bond or an optionally substituted C 1 -C 6 alkylidene chain wherein up to two non-adjacent methylene units of Q and up to three non-adjacent methylene units of Z are optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; each occurrence of R 5 , R 7 and R 8 is independently R′, halogen, NO 2 , CN, OR′, SR′, N(R′) 2 , NR′C(O)R′, NR′C(O)N(R′) 2 , NR′CO 2 R′, C(O)R′, CO 2 R′, OC(O)R′, C(O)N(R′)2, OC(O)N(R′)2, SOR′, SO 2 R′, SO 2 N(R′) 2 , NR′SO 2 R′, NR′SO 2 N(R′) 2 , PO(OR′) 2 , C(O)C(O)R′, or C(O)CH 2 C(O)R′; and each occurrence of R is independently hydrogen or an optionally substituted C 1-6 aliphatic group; and each occurrence of R′ is independently hydrogen or an optionally substituted group selected from C 1-8 aliphatic, C 6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms, or wherein two occurrences of R and R′ taken together or two occurrences of R′ taken together, form an optionally substituted saturated, partially unsaturated, or fully unsaturated 3-8 membered ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, provided that R 3 and R 4 are not simultaneously hydrogen.