Patent ID: 7538103

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is hydroxy, alkoxy, CO 2 R 12 , CON(R 13 )(R 14 ), OCON(R 13 )(R 14 ), or N(R 15 )(R 16 ); or R 2 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 alkyl substituents; or R 2 is R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 )(R 10 )NSO 2 , or (R 11 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, alkoxycarbonyl, benzyl, benzyloxycarbonyl, or pyridinyl; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 alkyl substituents; R 12 is hydrogen or alkyl; R 13 is hydrogen or alkyl; R 14 is hydrogen or alkyl; or N(R 13 )(R 14 ) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl and is substituted with 0-3 alkyl substituents; R 15 is hydrogen, alkyl, or alkylCO; R 16 is hydrogen or alkyl; and or a pharmaceutically acceptable salt thereof.