Patent ID: 8404673

Claim:
A method of treating a disorder selected from the group consisting of treatment of psychoses, pain, dysfunction in memory and learning, attention deficit, schizophrenia, dementia, and Alzheimer's disease comprising administering to a patient having such disorder a therapeutically effective amount of a compound of formula IA or IB wherein R 1 and R 2 are each independently hydrogen, lower alkyl, (CH 2 ) o -cycloalkyl where o is 0 or 1, or are benzyl or heterocycloalkyl; or R 1 and R 2 together with the N-atom to which they are attached form a ring containing —(CH 2 ) 3 —, —(CH 2 ) 4 —, —(CH 2 ) 5 —, —(CH 2 ) 2 —O—(CH 2 ) 2 —, —(CH 2 ) 2 —S—(CH 2 ) 2 —, —(CH 2 ) 2 —NR—(CH 2 ) 2 —, —(CH 2 ) 2 —C(O)—(CH 2 ) 2 —, —(CH 2 ) 2 —CF 2 —(CH 2 ) 2 —, —CH 2 —CHR—(CH 2 ) 2 , —CHR—(CH 2 ) 3 , CHR—(CH 2 ) 2 —CHR—, or is the ring 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester and R is hydroxy, halogen, cycloalkyl, or C(O)O-lower alkyl; X is —(CH 2 ) 4 —, —(CH 2 ) 3 —, —(CH 2 ) 2 — or —CH 2 —; R 4 is CF 3 , lower alkoxy, lower alkyl, or halogen and n is 1 or 2; or a pharmaceutically acceptable acid addition salt, a racemic mixture, enantiomer or optical isomer thereof.