Patent ID: 7592448

Claim:
A method of producing a compound of formula (I) wherein X is H, and Y is H or NO 2 , comprising (1) fluoroacylation of a compound of formula (II) to protect non-acylated secondary amine groups at the n-4 positions, n-10 positions or both n-4 and n-10 positions and produce a fluoroacylated compound wherein formula (II) comprises: wherein X and Y are H, or X is Ac and Y is H, and Ac is —COCH 3 , —COCH 2 R, where R is C 1-10 alkyl (linear or branched), —CH 2 —C 6 H 5 , or C 1-10 arylalkyl; (2) nitrolysis of the fluoroacylated compound to produce a nitrolyzed compound, and (3) deprotection by solvolysis of the nitrolyzed compound.