Patent ID: 8344147

Claim:
A process for producing Compound 1 having solid Form B: comprising: (a) reacting Compound 2 with the hydrochloride salt of Compound 3 (3-HCl) in the presence of a coupling agent selected from the group consisting of 2-chloro-1,3-dimethyl-2-imidazolium tetrafluoroborate, HBTU, HCTU, 2-chloro-4,6-dimethoxy-1,3,5-thazine, HATU, HOBT/EDC, and 2-propane phosphonic anhydride wherein the Form B is characterized by a peak at about 165.3 ppm, a peak at about 145.9 ppm, a peak at about 132.9 ppm , and a peak about 113.4 ppm in a 13 C NMR spectrum.