Patent ID: 7947714

Claim:
A compound of the formula I: wherein: R 1 is selected from the group consisting of: (1) —CH 2 -cyclopropyl, (2) piperidinyl, (3) N-methyl-piperidinyl, (4) N-methyl-piperazinyl, (5) morpholinyl, (6) isobutyl, (7) —CH 2 -tetrahydropyranyl and (8) —CH 2 -tetrahydrofuranyl; R 9 is independently selected from: (a) hydrogen, (b) —C 1-6 alkyl, which is unsubstituted or substituted with 1-6 fluoro, (c) benzyl, and (d) phenyl, R 10 and R 11 are independently selected from: (a) hydrogen, (b) —C 1-6 alkyl, which is unsubstituted or substituted with hydroxy, 1-6 fluoro or —NR 12 R 13 , where R 12 and R 13 are independently selected from hydrogen and —C 1-6 alkyl, (c) —C 3-6 cycloalkyl, which is unsubstituted or substituted with hydroxy, 1-6 fluoro or —NR 12 R 13 , (d) benzyl, and (e) phenyl; R 2 is selected from the group consisting of: (1) phenyl, which is substituted with R 2a , R 2b and R 2c , (2) heterocycle, which is substituted with R 2a , R 2b and R 2c , (3) C 1-8 alkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxy, —NR 10 R 11 , phenyl or heterocycle, where the phenyl or heterocycle is substituted with R 2a , R 2b and R 2c , (4) C 3-6 cycloalkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxy or —NR 10 R 11 , and (5) —C 1-6 alkyl-(C 3-6 cycloalkyl), which is unsubstituted or substituted with 1-6 halogen, hydroxy or —NR 10 R 11 ; R 2a , R 2b and R 2c are independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —C 1-6 alkyl, which is unsubstituted or substituted with: (a) 1-6 halogen, (b) phenyl, (c) C 3-6 cycloalkyl, or (d) —NR 10 R 11 , (4) —O—C 1-6 alkyl, which is unsubstituted or substituted with 1-6 halogen, (5) —O-phenyl, (6) hydroxy, (7) —SCF 3 , (8) —SCHF 2 , (9) —SCH 3, (10) —CO 2 R 9 , (11) —CN, (12) —SO 2 R 9 , (13) —SO 2 —NR 10 R 11 , (14) —NR 10 R 11 , (15) —CONR 10 R 11 , and (16) —NO 2; R 3 is selected from the group consisting of: (1) C 1-6 alkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxyl, —NR 10 R 11 , (2) C 3-6 cycloalkyl, which is unsubstituted or substituted with 1-6 halogen, hydroxyl or —NR 10 R 11 , (3) —C 1-6 alkyl-(C 3-6 cycloalkyl), which is unsubstituted or substituted with 1-6 halogen, hydroxy or -NR 10 R11, and (4) —NR 10 R 11 ; with the proviso that if R 1 is —CH 2 -cyclopropyl, then R 3 is —NR 10 R 11 or —C 1-6 alkyl-(C 3-6 cycloalkyl), which is unsubstituted or substituted with 1-6 halogen, hydroxy or —NR 10 R 11 ; R 4 and R 5 are independently selected from the group consisting of: (1) hydrogen, and (2) C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, or R 4 and R 5 taken together form a C 3-6 cycloalkyl ring; A is selected from the group consisting of: (1) —O—, and (2) —NR 10 —; m is zero or one, whereby when m is zero, R 2 is attached directly to the carbonyl; and pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof.