Patent ID: 8053429

Claim:
A solid oral dosage form which is effective in delivering a drug and an enhancer, each as defined below, to an intestine and which consists of a pharmaceutical composition consisting of: (A) a therapeutically effective amount of a hydrophilic or macromolecular drug; (B) one or more absorption enhancers, each of which: (i) is a solid at room temperature; (ii) is a salt of a medium chain fatty acid having a carbon length of from 8 to 14 carbon atoms; and (iii) is present in the dosage form such that the ratio of the drug to the one or more absorption enhancers is 1:100,000 to 10:1; (C) one or more excipients selected from the group consisting of rate-controlling polymeric materials, diluents, lubricants, disintegrants, plasticizers, anti-tack agents, opacifying agents, pigments, and flavorings; and optionally, a controlled release coating; wherein the solid oral dosage form is a tablet, a multiparticulate compressible to form a tablet, or a capsule containing a multiparticulate compressible to form a tablet.