Patent ID: 7320979

Claim:
An N-[(piperazinyl)hetaryl]arylsulfonamide compound of the general formula I in which R is oxygen, a group N—R 3 or a group CR 3a R 3b ; Q is a bivalent, 6-membered heteroaromatic radical selected from pyridindiyl and pyrimidindiyl, and which optionally carries one or two substituents R a which is/are selected, independently of each other, from halogen, CN, NO 2 , CO 2 R 4 , COR 5 , C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl, NH 2 , NHR 6 , NR 6 R 7 and C 1 -C 4 -haloalkoxy; Ar is phenyl or a 6-membered heteroaromatic radical selected from pyridinyl and pyrimidinyl, and which carries one or two substituents R b , which is/are selected from halogen, NO 2 , CN, CO 2 R 4 , COR 5 , NHR 6 , NR 6 R 7 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, C 3 -C 6 -cycloalkoxy, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyl and C 1 -C 4 -haloalkyl, with it also being possible for two radicals Rb which are bonded to adjacent C atoms of Ar to be together C 3 -C 4 -alkylene; n 0, 1 or 2; R 1 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 4 -alkenyl or C 3 -C 4 -alkynyl; R 2 is C 1 -C 4 -alkyl or, together with R 1 , is C 2 -C 5 -alkylene or, in the case of n=2, the two radicals R 2 can together be C 1 -C 4 -alkylene; R 3 is hydrogen or C 1 -C 4 -alkyl; R 3a , R 3b are, independently of each other, hydrogen or C 1 -C 4 -alkyl; R 4 is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 2 -C 4 -alkenyl C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyl, phenyl or benzyl; and R 5 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 2 -C 4 -alkenyl C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkyl, phenyl or benzyl; R 6 , R 7 are each independently selected from C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or together with the nitrogen to which they are bound form a saturated 3-, 4-, 5- or 6-membered heterocycle, which additionally may comprise an oxygen atom or an additional nitrogen atom as a ring member and which may carry 1, 2, 3 or 4 C 1 -C 4 alkyl groups; the N-oxides thereof and the physiologically tolerated acid addition salts of these compounds; with the exception of the compounds: 4-methyl-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl) benzenesulfonamide and 4-chloro-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl) benzenesulfonamide.