Patent ID: 7125889

Claim:
A method of reducing blood clots in a mammal comprising: concurrently administering to the mammal a therapeutically effective amount for reducing blood clots of a combination of a compound selected from the group consisting of pyridoxal-5′-phosphate, pyridoxal, pyridoxamine, a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, and a mixture thereof, and a cardiovascular compound selected from the group consisting of pyridoxal phophate-6-azophenyl-2′,4′-disulphonic acid (PPADS) and an anti-thrombotic agent, wherein the 3-acylated pyridoxal analogue is a compound of the formula wherein R 1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom; an alkoxy group; a dialkylamino group; or an unsubstituted or substituted aryl group; and R 2 is a secondary amino group.