Patent ID: 8465764

Claim:
A method for producing a drug selected from the group consisting of cisplatin and dihydrate cisplatin, in a yield of up to 80 mol %, comprising: (1) reacting magnetic particle-containing carbon nanocapsules having a diameter in the range of 30-40 nm, the magnetic particles comprising Fe, Co, Ni or an alloy thereof, with an effective amount of a reagent to modify the surface of the nanocapsules to provide >C(—COOH) 2 functional groups thereon; (2) reacting said >C(—COOH) 2 functional groups with platinum cations to bind the platinum cations to the >C(—COOH) 2 functional groups and form stable cis-form platinum complexes on said nanocapsules; (3) aminating the stable cis-form platinum complex nanocapsules by reacting said nanocapsules with ammonia to form an aminated cis-form platinum nanocapsule complex; and (4) hydrolyzing the aminated cis-form platinum nanocapsule complex to form cisplatin or dihydrate cisplatin; wherein the magnetic particle-containing carbon nanocapsule is a polyhedral carbon cluster composed of an outer shell having an enclosed multilayer graphite structure containing the magnetic particles inside; the number of functional groups—COOH is 123 mmol/g; and the surface modifying reagent is diethylbromomalonate.