Patent ID: 7494821

Claim:
A compound represented by Formula I, comprising: wherein A 1 is aryl or heteroaryl, both of which are optionally substituted with one or more of halogen, alkoxyl, —OH, —N(R 12 ) 2 , —COR 12 , —CO 2 R 12 , —N(R 12 )C(O)R 12 , or —C(O)N(R 12 ) 2 ; X 1 is —OR 9 , —SR 9 , —N═R 9 , or —N(R 13 )R 9 ; X 2 is —OR 13 , —SR 13 , or —N(R 13 ) 2 ; X 3 is —O—, —S—, or —N(R 13 )—; R 1 , R 3 , R 5 , R 7 , R 8 and R 10 each represent independently for each occurrence H, alkyl, aryl or heteroaryl; or R 1 and R 8 taken together form a bond; or R 5 and R 7 taken together form a bond; R 2 , R 4 , and R 6 each represent independently for each occurrence H, alkyl, aryl, heteroaryl, aralkyl, halogen, alkoxyl, —COR 12 , or —CO 2 R 12 ; or R 2 and R 3 taken together form a bond; or R 4 and R 9 taken together form a 5-6 member ring optionally substituted with one or more of alkyl, hydroxyalkyl, aryl, aralkyl, halogen, alkoxyl, —N(R 9 ) 2 , —COR 9 , —CO 2 R 9 , —N(R 9 )C(O)R 9 , or —C(O)N(R 9 ) 2 ; R 9 is H, alkyl, aryl, heteroaryl, or aralkyl; R 11 is H, alkyl, aryl, heteroaryl, aralkyl, or halogen; R 12 represents independently for each occurrence H, alkyl, aryl, heteroaryl, or aralkyl; R 13 represents independently for each occurrence H or (C 1 -C 6 )alkyl; m represents independently for each occurrence 0, 1, 2, 3, or 4; and the stereochemical configuration at any stereocenter of a compound represented by I is R, S, or a mixture of these configurations.