Patent ID: 8022063

Claim:
A compound of formula (IV) or a salt thereof wherein A is —COOH or a carboxyl bioisostere selected from —SO 2 NHR and —P(═O)(OH)(OR) wherein R is hydrogen methyl or ethyl, —SO 2 OH, —P(═O)(OH)(NH 2 ), —C(═O)NHCN, and groups of formulae: A 1 is hydrogen or methyl; and ring Ar 2 represents a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted with up to four compatible substituents independently selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, hydroxy(C 1 -C 6 )alkyl, mercapto, mercapto(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, halo including fluoro, bromo and chloro, fully or partially fluorinated (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy or (C 1 -C 3 )alkylthio such as trifluoromethyl, trifluoromethoxy, and trifluoromethylthio, nitro, nitrile (—CN), oxo, phenyl, phenoxy, —COOR A , —COR A , —OCOR A , —SO 2 R A , —CONR A R B , —SO 2 NR A R B , —NR A R B , —OCONR A R B , —NR B COR A , —NR B COOR A , —NR B SO 2 OR A or —NR A CONR A R B wherein R A and R B are independently hydrogen or a (C 1 -C 6 )alkyl group or, in the case where R A and R B are linked to the same N atom, R A and R B taken together with that nitrogen may form a cyclic amino ring, and where the substituent is phenyl or phenoxy, the phenyl ring thereof may itself be substituted by any of the above substituents except phenyl or phenoxy groups, R 13 represents hydrogen or one or more optional substituents selected from fluoro, chloro, bromo, iodo, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, (C 1 -C 3 alkyl)SO 2 —, NH 2 SO 2 —, (C 1 -C 3 alkyl)NHSO 2 —, (C 1 -C 3 alkyl) 2 NSO 2 —, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, cycloalkyl, aryl, aryloxy, aryl(C 1 -C 6 )- or aryl(C 1 -C 6 alkoxy)-, L2 is a divalent radical selected from the following wherein either (i) the bond marked * is attached to Ar 2 while the bond marked ** is attached to the phenyl ring, or (ii) the bond marked * is attached to the phenyl ring while the bond marked ** is attached to Ar 2 : wherein R is hydrogen or C 1 -C 3 alkyl.