Patent ID: 8003621

Claim:
A therapeutic compositions comprising: A cationic polymeric carrier which comprises a recurring polyethylene glycol (PEG) unit; a recurring polyethyleneimine (PEI) unit; a targeting agent comprising a retinoid; and a recurring degradable unit, wherein the cationic polymeric carrier comprises the following structure: and a therapeutic agent operatively associated with the cationic polymeric carrier, wherein the therapeutic agent exhibits a therapeutic activity upon delivery to a target organ or tissue, and wherein the therapeutic activity is selected from the group consisting of inhibiting fibrosis within the target organ or tissue and inhibiting the growth of a cancer cell within the target organ or tissue; wherein the R 2 is selected from the group consisting of oleyl, lauryl, myristyl, palmityl, margaryl, stearyl, arachidyl, behenyl, lignoceryl and a sterol.