Patent ID: 8288349

Claim:
An anti-angiogenic (AA) targeting agent comprising a peptide comprising the following sequence: (SEQâ€ƒIDâ€ƒNO:â€ƒ43) R 1 -Q 1 (AcK) 2 Y 3 Q 4 P 5 L 6 D 7 E 8 (AcK) 9 D 10 K 11 T 12 L 13 Y 14 D 15 Q 16 F 17 M 18 L 19 Q 20 Q 21 G 22 -R 2 wherein R 1 is CH 3 , C(O)CH 3 , C(O)CH 3 , C(O)CH 2 CH 3 , C(O)CH 2 CH 3 , C(O)CH(CH 3 )CH 3 , C(O)CH 2 CH 2 CH 2 CH 3 , C(O)CH(CH 3 )CH 2 CH 3 ,C(O)C 6 H 5 , C(O)CH 2 CH 2 (CH 2 CH 2 O) 1-5 Me, dichlorobenzoyl (DCB), difluorobenzoyl (DFB), pyridinyl carboxylate (PyC) or amido-2-PEG, an amino protecting group, a lipid fatty acid group or a carbohydrate; and R 2 is OH, NH 2 , NH(CH 3 ), NHCH 2 CH 3 , NHCH 2 CH 2 CH 3 , NHCH(CH 3 )CH 3 , NHCH 2 CH 2 CH 2 CH 3 , NHCH(CH 3 )CH 2 CH 3 , NHC 6 H 5 , NHCH 2 CH 2 OCH 3 , NHOCH 3 , NHOCH 2 CH 3 , a carboxy protecting group, a lipid fatty acid group or a carbohydrate, and pharmaceutically acceptable salts, stereoisomers, and solvates thereof.