Patent ID: 7388007

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R 1 is hydrogen, C 1-6 alkyl or NHR 3 ; R 2 is C 1-6 alkyl, C 3-6 alkenyl, C 3-6 cycloalkyl or C 3-6 cycloalkyl(C 1-4 alkyl) in which each group is optionally substituted with a group selected from halogen, CF 3 , CF 2 H, OH, OCF 3 and C 1-4 alkoxy; R 3 is —C(═O)R 10 , —C(═O)OR 10 , —C(═O)NHR 10 , —S(O) n R 10 or C 1-6 alkyl optionally substituted with a group selected from C 3-6 cycloalkyl, halogen, CF 3 , OCF 3 , OH, C 1-4 alkoxy and CN; R 4 is C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 alkyl), phenyl or phenyl(C 1-4 alkyl) in which each group is optionally substituted with the group selected from halogen, C 1-4 alkyl, OH, C 1-4 alkoxy, CF 3 , CF 2 H, OCF 3 and CN; R 5 is C 1-6 alkyl, phenyl or phenyl(C 1-4 alkyl) in which each group is optionally substituted with one or two groups selected from halogen, C 1-4 alkyl, OH, CF 3 , OCF 3 and CN; R 6 is R 7 is hydrogen or C 1-4 alkyl; n is 1 or 2; Y is O, NR 7 or S(O) n ; Z is CH 2 , O or S; R 8 and R 9 each are independently hydrogen, C 1-4 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, phenyl or pyridyl in which said phenyl and pyridyl are optionally substituted with C 1-4 alkyl, fluoroC 1-4 alkyl, C 1-4 alkoxy, halogen or CN; or YR 8 and R 9 are joined together with the carbon to which they are attached to form a 5- or 6-membered ring wherein Y is oxygen, and R 8 and R 9 are —CH 2 (CH 2 ) n —O—; and R 10 is C 1-4 alkyl optionally substituted with the group selected from halogen, OH, CF 3 , NH 2 and C 1-4 alkoxy; or a nontoxic pharmaceutically acceptable salt thereof.