Patent ID: 8067391

Claim:
A method of treating or preventing malaria comprising administering to a subject in need thereof a anti-malarial effective amount of a compound selected from a compound of Formula I, tautomers thereof and pharmaceutically acceptable salts, solvates, and prodrugs thereof: wherein, R 1 is selected from CN, N 3 , I, Br, NH 2 , NO 2 , C(O)C 1-6 alkyl, NH 1 —C 6 alkyl, N(C 1 -C 6 alkyl) 2 , NHC(O)C 1 -C 6 alkyl and NHC(O)OC 1 -C 6 alkyl; R 2 is selected from H, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, fluoro-substituted-C 1 -C 6 alkyl, fluoro-substituted-C 1 -C 6 alkoxy, N 3 , NH 2 and CN; R 3 is selected from OH, NH 2 , H and NHC(O)C 1 -C 6 alkyl; Z is selected from: wherein, R 4 is selected from H, C 1 -C 6 alkyl and hydroxy-substituted-C 1 -C 6 alkyl; One of R 5 and R 6 is hydrogen and the other is selected from H, OH and F and one of R 5′ and R 6′ is hydrogen and the other is selected from H, OH and F or R 5 and R 6 or R 5′ and R 6′ together is ═O or ═CH 2 ; R 7 is selected from H, F and OH; R 8 is selected from H, C(O)C 1 -C 6 alkyl, P(O)(OH) 2 , P(O)(OC 1 -C 6 alkyl) 2 and P(O)(OC 1 -C 6 alkyl)OH; R 9 is selected from H, N 3 , CN, C 1 -C 6 alkyl; and X—Y is selected from —CH 2 —O—, —O—CH 2 — and —S—CH 2 —.