Patent ID: 8168786

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: r and s are each independently an integer ranging from 0 to 6; R 1 is —H, -aryl, —C 1 -C 6 alkyl, —C 3 -C 7 cycloalkyl, —C 3 -C 7 cycloalkenyl, or -3- to 7-membered heterocycle; R 2 is —H, -aryl, —C 1 -C 6 alkyl, —C 3 -C 7 cycloalkyl, —C 3 -C 7 cycloalkenyl, -3- to 7-membered heterocycle, -halo, —CF 3 , —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —N(R 4 ) 2 , —CN, —OR 4 or —SR 4 ; R 3 is -aryl or -5- to 7-membered aromatic heterocycle, each of which is substituted with one R 6 group and optionally substituted with one or more of the following groups: —C 1 -C 6 alkyl, —C 3 -C 7 cycloalkyl, —C 3 -C 7 cycloalkenyl or -3- to 7-membered heterocycle, -halo, —CF 3 , —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —(C 1 -C 6 alkylene)-aryl, —N(R 4 ) 2 , —CN, —OR 4 , —SR 4 , —S(O)—R 4 , —SO 2 —R 4 , —SO 2 NH—R 4 , —SO 3 H, —NH—SO 2 —R 4 , —C(O)R 5 or —NHC(O)R 5 ; each occurrence of R 4 is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, -aryl, —(C 1 -C 6 alkylene)-aryl, —C 3 -C 7 cycloalkyl, —C 3 -C 7 cycloalkenyl or -3- to 7-membered heterocycle; R 5 is —R 4 , —N(R 4 ) 2 or —OR 4 ; R 6 is -M-Q, —O-M-Q, —S-M-Q, —NH-M-Q, —F, — 18 F, — 18 F-labeled CF 3 , —CF 2 H, — 18 F-labeled CF 2 H, or — 11 C-labeled CN; M is — 11 C-labeled C 1 -C 6 alkylene-, — 11 C-labeled C 2 -C 6 alkenylene-, — 11 C-labeled C 2 -C 6 alkynylene-, — 18 F-labeled C 1 -C 6 alkylene-, — 18 F-labeled C 2 -C 6 alkenylene-, or — 18 F-labeled C 2 -C 6 alkynylene-; Q is —H or -aryl.