Patent ID: 8481753

Claim:
A method for manufacturing isoindolic compound which comprises a thermal treatment step where a compound of which molecule includes a structure of pyrrole fused with bicyclo [2.2.2] octadiene skeleton is subjected to a supercritical carbon dioxide atmosphere, wherein the compound of which molecule includes the structure of pyrrole fused with bicyclo [2.2.2] octadiene skeleton is represented by the following general formula (1): where in the general formula (1), Y 1 and Y 3 mutually independently represent hydrogen, linear- or branched-alkyl group having a carbon number of 1-18, cyclic alkyl group having a carbon number of 3-18, linear- or branched-alkenyl group having a carbon number of 2-18, cyclic alkenyl group having a carbon number of 3-18, aralkyl group having a carbon number of 7-20, aryl group having a carbon number of 6-18, halogen atom, nitro group, nitroso group, cyano group, isocyano group, cyanato group, isocyanato group, thiocyanato group, isothiocyanato group, mercapto group, hydroxy group, hydroxyamino group, formyl group, sulfo group, carboxyl group, acyl group, amino group, acylamino group, carbamate group, carboxylate group, acyloxy group, carbamoyl group, sulfonyl group, sulfamoyl group, sulfonate group, sulfonamide group, sulfinyl group, or heterocyclic group; Y 2 represents hydrogen, linear- or branched-alkyl group having a carbon number of 1-18, cyclic alkyl group having a carbon number of 3-18, linear- or branched-alkenyl group having a carbon number of 2-18, cyclic alkenyl group having a carbon number of 3-18, aralkyl group having a carbon number of 7-20, aryl group having a carbon number of 6-18, formyl group, sulfo group, carboxyl group, acyl group, carboxylate group, acyloxy group, carbamoyl group, sulfonyl group, sulfamoyl group, silyl group, or heterocyclic group; and X 1 -X 4 mutually independently represent hydrogen, linear- or branched-alkyl group having a carbon number of 1-18, cyclic alkyl group having a carbon number of 3-18, linear- or branched-alkenyl group having a carbon number of 2-18, cyclic alkenyl group having a carbon number of 3-18, aralkyl group having a carbon number of 7-20, aryl group having a carbon number of 6-18, halogen atom, nitro group, nitroso group, cyano group, isocyano group, cyanato group, isocyanato group, thiocyanato group, isothiocyanato group, mercapto group, hydroxy group, hydroxyamino group, formyl group, sulfo group, carboxyl group, acyl group, amino group, acylamino group, carbamate group, carboxylate group, acyloxy group, carbamoyl group, sulfonyl group, sulfamoyl group, sulfonate group, sulfonamide group, or sulfinyl group; wherein X 2 and X 3 may be optionally linked together to form a ring structure.