Patent ID: 7666879

Claim:
A compound of Formula (I): wherein: R 1 : is (a) 2-pyridonyl optionally substituted with —(CH 2 ) 1-4 NR 2 R 3 ; or (b) phenyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, pyridinyl, N-oxo-pyridinyl, or pyrimidinyl, all of which are optionally substituted with —(CH 2 ) 0-4 NR 2 R 3 , C 1 -C 6 alkyl optionally substituted with amino, pyrrolidinyl, or morpholinyl, or 1-2 substituents independently selected from the group consisting of C 1 -C 4 alkoxy, halo, (C 1 -C 6 alkyl)sulfonyl, nitro, -sulfonyl(CH 2 ) 0-4 NR 2 R 3 , and -carbonyl(CH 2 ) 0-4 NR 2 R 3 ; R 2 is hydrogen or C 1 -C 6 alkyl optionally substituted with hydroxy; R 3 is hydrogen or C 1 -C 6 alkyl optionally substituted with hydroxy, trifluoromethyl, or pyrrolidinyl; or R 2 , R 3 , and the nitrogen to which they are attached form piperidinyl, piperazinyl optionally substituted with C 1 -C 6 alkyl, or morpholinyl; R 4 is thiazolyl, pyridinyl, or phenyl optionally substituted with 1-3 substituents selected from the group consisting of halo, amino, methyl, trifluoromethyl, and nitro; R 5 is C(O)NHR 6 , OC(O)NHR 6 , NHC(O)CH 2 R 6 , NHC(O)NHR 6 or C(S)NHR 6 ; n is 0-4 for OC(O)NHR 6 , NHC(O)CH 2 R 6 , NHC(O)NHR 6 and n is 1-4 for C(O)NHR 6 and C(S)NHR 6 ; and R 6 is (a) unsubstituted tetrahydrobenzothiazolyl; or (b) phenyl, pyridinyl, pyrimidinyl, pyrazolyl, thiazolyl, isothiazolyl, thiadiazolyl, isoxazolyl, all of which are optionally substituted with 1-3 substituents independently selected from the group consisting of C 1 -C 6 alkyl optionally substituted with hydroxy, dimethylamino, pyrrolidinyl, piperidinyl, or morpholinyl, C 2 -C 6 alkenyl optionally substituted with dimethylaminocarbonyl, C 1 -C 6 alkoxy, trifluoromethyl, difluoromethoxy, trifluoromethoxy, dimethylaminoethoxy, phenoxy, tolyl, halo, methylsulfonyl, dimethylamino, diethylamino, cyano, C 3 -C 6 cycloalkyl optionally substituted with hydroxy, methoxy, methoxyethoxy, or methyl, 3,4-dimethylisoxazol-5-yl-aminosulfonyl, tetrahydropyranyl, tetrahydropyranylaminocarbonyl, C 2 -C 6 alkylcarbonyl, morpholinylcarbonyl, and piperazinylcarbonyl; or pharmaceutically acceptable salts thereof.