Patent ID: 8513235

Claim:
An amide derivative represented by the following formula (I) wherein R 1 is a hydrogen atom or a C 1 -C 3 alkyl group, R 2 is an optionally substituted heterocyclic group (said heterocyclic group contains at least one nitrogen atom in the ring), or —N(R 2a )(R 2b ), R 2a and R 2b are independently selected and each is a hydrogen atom, a C 1 -C 6 alkyl group, a haloalkyl group or an optionally substituted aryl group, R 3 is a hydrogen atom, R 4 , R 5 , R 6 , R 7 are independently selected and each is a hydrogen atom or a C 1 -C 4 alkyl group, L is a linker represented by the following formula wherein s is an integer of 0-2, t is an integer of 0-2, R 8a , R 8b , R 8c and R 8d are independently selected and each is a hydrogen atom or a C 1 -C 3 alkyl group, Ar is a substituent represented by any of the following formulas (II)-(IV), wherein l is an integer of 0-4, k is an integer of 0-4, Cy 1 and Cy 2 are independently selected and each is a carbocyclic group, a heterocyclic group or a heteroaryl group, X is a bond, an oxygen atom or a sulfur atom, R 9 is a halogen atom or R 12 , wherein R 12 is a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 2 -C 6 alkenyl group, an optionally substituted C 2 -C 6 alkynyl group, an optionally substituted C 3 -C 8 cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aryl group, an optionally substituted heteroaryl group, or an optionally substituted arylalkyl group, R 10 is a halogen atom, a cyano group, an optionally substituted C 1 -C 6 alkyl group, —CF 3 , —O—R 13 , —CO—R 14 , an optionally substituted amino group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted heterocyclic group, or an —S(O) m —C 1 -C 6 alkyl group wherein m is an integer of 0-2, R 11 is a halogen atom, an optionally substituted C 1 -C 4 alkyl group or CF 3 , R 13 is a hydrogen atom, a C 1 -C 4 alkyl group, or —CF 3 , R 14 is a hydroxy group, a C 1 -C 6 alkyl group, a C 1 -C 6 alkoxy group, or an optionally substituted amino group, A is an optionally substituted aryl group, an optionally substituted aryl-C 1 -C 4 alkyl group, an optionally substituted heteroaryl-C 1 -C 4 alkyl group, a C 3 -C 6 alkynyl group, an optionally substituted C 3 -C 8 cycloalkyl group, or a group represented by any of the following formulas (V)-(VIII) wherein ----- is a single bond or a double bond, n is an integer of 0-2, g is an integer of 0-2, h is an integer of 0-1, i is an integer of 1-2, R 15 is a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group, a cyano group or a halogen atom, R 16 is a C 1 -C 4 alkyl group, W is ═CH— or ═N—, and D is an oxygen atom, a sulfur atom, ═N-(E)u-R 17 or ═CH—R 17 , u is an integer of 0-1, E is —SO 2 — or —CO—, R 17 is a hydrogen atom, a C 1 -C 4 alkyl group, an aryl group, a C 1 -C 4 alkylamino group, a C 1 -C 6 alkoxy group, an arylamino group or an aryloxy group, or a pharmacologically acceptable salt thereof.