Patent ID: 8052966

Claim:
A method of inhibiting tumor metastasis in a human patient having a tumor that has metastasized, said method comprising: intravenously administering to the patient a therapeutically effective amount of retroviral particles at a cumulative dose of at least 1.8×10 11 colony forming units (cfu), wherein each of the retroviral particles comprises: i) a modified retroviral envelope protein wherein the retroviral envelope protein includes a receptor binding region which has been modified to contain a collagen binding domain comprising a peptide comprising the amino acid sequence Gly-His-Val-Gly-Trp-Arg-Glu-Pro-Ser-Phe-Met-Ala-Leu-Ser-Ala-Ala (SEQ ID NO:1), and ii) encodes a heterologous therapeutic polypeptide.