Patent ID: 8551789

Claim:
A method of screening an agent for activity as an inhibitor of Wnt signaling, comprising: a) contacting a human frizzled (FZD) receptor or a Wnt binding fragment thereof with i) a polypeptide that binds the FZD receptor and ii) a test agent, wherein the polypeptide comprises a sequence selected from the group consisting of SEQ ID NOs:98-116; and b) detecting competition by the agent with the polypeptide for binding to the FZD receptor, wherein the ability of the agent to compete for binding with the polypeptide indicates the agent has activity as an inhibitor of Wnt signaling; or detecting displacement of the polypeptide binding the FZD receptor by the agent, wherein the ability of the agent to displace the polypeptide indicates the agent has activity as an inhibitor of Wnt signaling.