Patent ID: 7563599

Claim:
A method for making a humanized antibody which binds to human medulloblastoma cells comprising: (a) providing complementary determining regions from a mouse antibody and framework regions from a human antibody; (b) substituting an amino acid residue of position 46 of an L chain numbered according to Kabat numbering with a corresponding residue from a mouse antibody; (c) substituting 5 amino acid residues at positions selected from the group consisting of 27, 28, 29, 30 and 94 of an H chain numbered according to Kabat numbering with a corresponding residue from a mouse antibody, wherein the L chain of the reshaped human antibody comprises the amino acid sequence selected from a group consisting of SEQ ID NOs: 69, 73, 77, 81, 87 and 91, and the H chain of the reshaped human antibody comprises the amino acid sequence as set forth of SEQ ID NO: 132.