Patent ID: 7892545

Claim:
A method to inhibit the formation of amyloid plaques or to inhibit the formation of toxic soluble Aβ species in humans, comprising administering to a human subject in need of such inhibition an effective amount of a humanized antibody, wherein said antibody comprises: a. a light chain comprising a light chain variable region comprising the following sequence: (SEQ ID NO: 7) 1 5 10 Asp Xaa Val Met Thr Gln Xaa Pro Leu Ser Leu Pro 15 20 Val Xaa Xaa Gly Gln Pro Ala Ser Ile Ser Cys Arg 25 30 35 Ser Ser Gln Ser Leu Xaa Tyr Ser Asp Gly Asn Ala 40 45 Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Xaa Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 65 70 Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 75 80 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 85 90 95 Ala Glu Asp Xaa Gly Val Tyr Tyr Cys Ser Gln Ser 100 105 Thr His Val Pro Trp Thr Phe Gly Xaa Gly Thr Xaa 110 Xaa Glu Ile Lys Arg wherein: Xaa at position 2 is Val or Ile; Xaa at position 7 is Ser or Thr; Xaa at position 14 is Thr or Ser; Xaa at position 15 is Leu or Pro; Xaa at position 30 is Ile or Val; Xaa at position 50 is Arg, Gln, or Lys; Xaa at position 88 is Val or Leu; Xaa at position 105 is Gln or Gly; Xaa at position 108 is Lys or Arg; and Xaa at position 109 is Val or Leu; and b. a heavy chain comprising a heavy chain variable region comprising the following sequence: (SEQ ID NO: 8) 1 5 10 Xaa Val Gln Leu Val Glu Xaa Gly Gly Gly Leu Val 15 20 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 25 30 35 Ser Gly Phe Thr Phe Ser Arg Tyr Ser Met Ser Trp 40 45 Val Arg Gln Ala Pro Gly Lys Gly Leu Xaa Leu Val 50 55 60 Ala Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr 65 70 Pro Asp Xaa Val Lys Gly Arg Phe Thr Ile Ser Arg 75 80 Asp Asn Xaa Xaa Asn Thr Leu Tyr Leu Gln Met Asn 85 90 95 Ser Leu Arg Ala Xaa Asp Thr Ala Val Tyr Tyr Cys 100 105 Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Xaa Val 110 Thr Val Ser Ser wherein: Xaa at position 1 is Glu or Gln; Xaa at position 7 is Ser or Leu; Xaa at position 46 is Glu, Val, Asp, or Ser; Xaa at position 63 is Thr or Ser; Xaa at position 75 is Ala, Ser, Val, or Thr; Xaa at position 76 is Lys or Arg; Xaa at position 89 is Glu or Asp; and Xaa at position 107 is Leu or Thr.