Patent ID: 7928220

Claim:
A chemically modified, short interfering nucleic acid (siNA) molecule, wherein: (a) the comprises a sense strand and a separate antisense strand, each strand having one or more pyrimidine nucleotides and one or more purine nucleotides; (b) each strand is independently 18 to 23 nucleotides in length; (c) the antisense strand is complementary to a human stromal cell-derived factor-1 (SDF-1) RNA sequence comprising SEQ ID NO: 907; (d) a plurality of the pyrimidine nucleotides present in the sense strand are 2′-deoxy-2′-fluoro pyrimidine nucleotides and a plurality of the purine nucleotides present in the sense strand are 2′-deoxy purine nucleotides; and, (e) a plurality of the pyrimidine nucleotides in the antisense strand are 2′-deoxy-2′-fluoro pyrimidine nucleotides and a plurality of the purine nucleotides present in the antisense strand are 2′-O-methyl purine nucleotides.