Patent ID: 7338973

Claim:
A compound of formula (I) wherein X is —O—; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, -C 1-4 alkyl—NR C R D and -L 1 R 4 -(L 2 ) c -R 5 ; is phenyl; a is 1; R 2 is selected from the group consisting of C 1-4 alkoxy, —O-aralkyl, —OC(O)—C 1-4 alkyl, —O—SO 2 —C 1-4 alkyl, —O—SO 2 -(halogenated C 1-4 alkyl) and —O—Si(CH 3 ) 2 (t-butyl); b is 1; R 3 is selected from the group consisting of halogen, hydroxy, carboxy, oxo, cyano, nitro, amino, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 alkyl, C 1-4 alkoxy, halogenated C 1-4 alkyl, —O-aralkyl, —C(O)—C 1-4 alkyl, —C(O)O—C 1-4 alkyl, —OC(O)—C 1-4 alkyl, —O—SO 2 —C 1-4 alkyl, —O—SO 2 -(halogenated C 1-4 alkyl) and —O—Si(CH 3 ) 2 (t-butyl); L 1 is selected from the group consisting of —CH 2 — and —C(O)—; R 4 is selected from the group consisting of a five to six membered aryl and a five to six membered heteroaryl; c is an integer selected from 0 to 1; L 2 is selected from the group consisting of —C 1-4 alkyl-, —C 2-4 alkenyl-, —O—C 1-3 alkyl-, —S—C 1-3 alkyl- and —NR B —C 1-3 alkyl-; wherein R B is selected from hydrogen or C 1-4 alkyl; R 5 is selected from the group consisting of —NR C R D , —C(O)—C 1-4 alkyl, —CO 2 H, —C(O)O—C 1-4 alkyl and —OC(O)—C 1-4 alkyl; wherein R C and R D are independently selected from hydrogen or C 1-4 alkyl; alternatively, R C and R D are taken together with the nitrogen atom to which they are bound to form a five to seven membered aromatic, partially aromatic or saturated ring structure; wherein the ring structure optionally contains one to two additional heteroatoms selected from O, N or S; or a pharmaceutically acceptable salt thereof.