Patent ID: 8198302

Claim:
A composition of the following formula (V): wherein a. Z is an ethylene (—CH═CH—) bridge in the cis (Z) isomeric configuration; b. R 1 and R 2 are OH or a prodrug form thereof; c. R 3 is selected from the group consisting of i) a C 1 , C 2 , C 3 , C 4 or C 5 branched or straight-chain lower alkoxy, cycloalkoxy, heterocycloalkoxy, aryloxy, or lower alkanoyloxy; ii) a halogen or trihaloalkyl; iii) a C 1 , C 2 , C 3 , C 4 or C 5 branched or straight chain lower alkyl, allyl, allyloxy, vinyl, or vinyloxy; iv) a C 1 , C 2 , C 3 , C 4 or C 5 primary, secondary, or tertiary alcohol; and v) oxo, lower alkanoyl, thio, sulfonyl, sulfonamide, nitro, nitrosyl, cyano, carboxy, carbamyl, aryl, or heterocycle; d. R 4 , R 5 , and R 9 are hydrogen, e. R 6 and R 8 are the same or different and selected from the group consisting of hydrogen and i) a C 1 , C 2 , C 3 , C 4 or C 5 branched or straight-chain lower alkoxy, cycloalkoxy, heterocycloalkoxy, aryloxy, or lower alkanoyloxy; ii) a halogen or trihaloalkyl; iii) a C 1 , C 2 , C 3 , C 4 or C 5 branched or straight chain lower alkyl, allyl, allyloxy, vinyl, or vinyloxy; or iv) a C 1 , C 2 , C 3 , C 4 or C 5 primary, secondary, or tertiary alcohol; and v) nitro; f. R 7 , is selected from the group consisting of i) a C 1 , C 2 , C 3 , C 4 or C 5 branched or straight-chain lower alkoxy, cycloalkoxy, heterocycloalkoxy, aryloxy, or lower alkanoyloxy; ii) a halogen or trihaloalkyl; iii) a C 1 , C 2 , C 3 , C 4 or C 5 branched or straight chain lower alkyl, allyl, allyloxy, vinyl, or vinyloxy; iv) a C 1 , C 2 , C 3 , C 4 or C 5 primary, secondary, or tertiary alcohol; and v) nitro; provided that said compound is not combretastatin A1 or prodrug thereof.