Patent ID: 7018988

Claim:
Pyrrolidine derivatives according to formula I as well as its geometrical isomers, its optically active forms as enantiomers, diastereomers and its racemate forms, as well as pharmaceutically acceptable salts thereof, wherein X is selected from the group consisting of O, S, CR 6 R 7 ,; A is selected from the group consisting of —(C═O)—, —C(═NH)—, —(C═O)—NH—, —(C═S)—NH, and —CH 2 —, B is a group —(C═O)—NR 8 R 9 R 1 is selected from the group consisting of unsubstituted or substituted C 1 –C 6 -alkyl, unsubstituted or substituted C 2 –C 6 -alkenyl, unsubstituted or substituted C 2 –C 6 -alkynyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3–8-membered cycloalkyl, acyl, unsubstituted or substituted C 1 –C 6 -alkyl aryl, and unsubstituted or substituted C 1 –C 6 -alkyl heteroaryl, wherein said cycloalkyl or aryl or heteroaryl groups may be fused with 1–2 further cycloalkyl or aryl or heteroaryl group; R 2 , R 3 , R 4 and R 5 are independently selected from each other from the group consisting of hydrogen, halogen, C 1 –C 6 -alkyl, and C 1 –C 6 -alkoxy; R 6 and R 7 are independently selected from the group consisting of hydrogen, unsubstituted or substituted C 1 –C 6 alkyl, unsubstituted or substituted C 2 –C 6 alkenyl, unsubstituted or substituted C 2 –C 6 alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted thioalkoxy, halogen, cyano, nitro, acyl, alkoxycarbonyl, aminocarbonyl, unsubstituted or substituted saturated or unsaturated 3–8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted C 1 –C 6 -alkyl aryl, and unsubstituted or substituted C 1 –C 6 -alkyl heteroaryl; R 8 , R 9 are independently selected from the group consisting of hydrogen, unsubstituted or substituted C 1 –C 6 alkyl, unsubstituted or substituted C 2 –C 6 alkenyl, unsubstituted or substituted C 2 –C 6 alkynyl, unsubstituted or substituted saturated or unsaturated 3–8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl, or each pair R 6 , R 7 and/or R 8 , R 9 may form together with the N atom to which they are attached a 3–8 membered substituted or unsubstituted, saturated or unsaturated hetero-cyclic ring which may contain 1–2 further heteroatoms selected from N, S and O and which is optionally fused with an aryl, heteroaryl or 3–8 membered saturated or unsaturated cycloalkyl ring; with the proviso that the following compounds are excluded: