Patent ID: 7670826

Claim:
An isolated nucleic acid molecule comprising: a) a polynucleotide sequence encoding SEQ ID NO: 13; b) a polynucleotide sequence that hybridizes under highly stringent conditions to a nucleic acid that is the full complement of the nucleic acid encoding the amino acid sequence as set forth in SEQ ID NO: 13, said highly stringent conditions include hybridization at 62° C. in buffer containing 50% formamide and a final wash at 67° C. in 0.5×SSC and 0.1% SDS and wherein said amino acid sequence increases transendothelial migration of leukocytes; c) a polynucleotide sequence encoding a polypeptide comprising amino acids 1-291 of SEQ ID NO: 13; d) a polynucleotide sequence encoding a polypeptide comprising amino acids 1-159 of SEQ ID NO: 13 and wherein said polypeptide inhibits transendothelial migration of leukocytes; e) a polynucleotide sequence encoding a polypeptide comprising amino acids 25-241 of SEQ ID NO: 13 and wherein said polypeptide inhibits transendothelial migration of leukocytes; f) a polynucleotide sequence encoding a polypeptide comprising amino acids 1-238 of SEQ ID NO: 13 and wherein said polypeptide inhibits transendothelial migration of leukocytes; g) a polynucleotide sequence that hybridizes under highly stringent conditions to a nucleic acid that is the full complement of the nucleic acid encoding amino acids 1-159 of SEQ ID NO: 13, amino acids 25-241 of SEQ ID NO: 13, or amino acids 1-238 of SEQ ID NO: 13, said highly stringent conditions include hybridization at 62° C. in buffer containing 50% formamide and a final wash at 67° C. in 0.5×SSC and 0.1% SDS and wherein said amino acid sequence inhibits transendothelial migration of leukocytes; or h) a polynucleotide sequence encoding a fusion protein comprising: i) amino acids 25-241 of SEQ ID NO:13; ii) amino acids 1-159 of SEQ ID NO: 13; or iii) amino acids 1-238 of SEQ ID NO: 13; wherein said fusion protein inhibits transendothelial migration of leukocytes.