Patent ID: 7320973

Claim:
A 5,11-Dihydrodiaryl[b,e][1,4]oxazepine represented by the following formula [I], a stereoisomer thereof, a pharmacologically acceptable salt thereof, or a hydrate thereof: wherein rings G, J and K each represent benzene ring or a nitrogen-containing aromatic ring; each of R1, R2, R3, R4, R5, R6, R7, and R8 may be the same or different from one another and they each represent a halogen atom or hydrogen atom, each of R9, R10, R11, R12, and R13 may be the same or different from one another and they each represent a hydrogen atom, a halogen atom, cyano group, hydroxyl group, a lower alkyl group, a lower alkoxyl group, amino group, a lower alkylamino group, a lower acylated amino group, a lower acylated lower alkylamino group, a lower dialkylamino group or a cycloalkylamino group, or R9 and R10 or R10 and R11 together form —O(CH 2 ) n′ O— group wherein n′ is 1, 2 or 3; A represents CH 2 , CHOH, CO or O; B represents CH 2 , CHOH or CO; or A-B represents CH═CH, D represents CH 2 , CH 2 —CH 2 or CH 2 —CH 2 —CH 2 or B-D represents CH 2 ; X and z are bonded together to form CH 2 —CH 2 or CH 2 —CH 2 —CH 2 and, in this case, Y represents a hydrogen atom; or Y and z are bonded together to form CH 2 —CH 2 —CH 2 or CH 2 —CH 2 —CH 2 —CH 2 and, in this case, X represents a hydrogen atom; and when X and z, and Y and z are not bonded together, X and Y each represent a hydrogen atom and z represents a lower alkyl group; provided that when any of R9, R10, R11, R12, and R13 represents a cyclic amino group of the following formula [E], each of R1, R2, R3, R4, R5, R6, R7, and R8 may be a halogen atom or hydrogen atom but when none of R9, R10, R11, R12, and R13 is a cyclic amino group of formula [E], one or two of R1, R2, R3, R4, R5, R6, R7, and R8 represent a halogen atom and the others represent a hydrogen atom: wherein n and m each represent 1 or 2, and W represents carbon atom, or nitrogen which may be substituted with a lower alkyl group, or oxygen, or sulfur atom.