Patent ID: 8642747

Claim:
A kit comprising an implantable pacemaker and a bio-pacemaker composition comprising at least two coding sequences selected from the group consisting of: (i) a coding sequence that encodes, in myocardial cells of cardiac Purkinje fibers, at least one T-type Ca 2+ channel subunit, wherein at least one of the T-type Ca 2+ channel subunits is α 1H ; (ii) a coding sequence that encodes, in myocardial cells of cardiac Purkinje fibers, one or more molecules that increase I f , wherein at least one of the one or more molecules that increase I f is selected from the group consisting of HCN1, HCN2, HCN3, or HCN4; and (iii) a coding sequence that encodes, in myocardial cells of cardiac Purkinje fibers, one or more molecules that increases I K , wherein at least one of the one or more molecular that increases I K is selected from the group consisting of erg1, MiRP, MinK, or KvLQT1.