Patent ID: 7790717

Claim:
A method for the treatment of schizophrenia in a subject in need of such treatment, comprising the step of administering to said subject a therapeutically effective amount of a compound according to Formula I: wherein: R 1 is selected from the group consisting of H, hydroxy, F, Cl, Br, I, nitro, CN, alkyl, alkylhalo, O-alkyl, O-alkylhalo, alkenyl, O-alkenyl, alkynyl, O-alkynyl, methylenedioxy and ethylenedioxy; L is selected from the group consisting of alkylene, alkenylene and alkynylene wherein any hydrogen atom of L may be independently substituted with one or more substituents selected from the group consisting of hydroxy, F, Cl, Br, I, alkyl, alkylhalo and O-alkyl; A is selected from the group consisting of aryl and heteroaryl; B is selected from the group consisting of alkylene, aryl, heteroaryl, cycloalkyl and heterocycloalkyl; D is selected from the group consisting of alkylene, O, O-alkylene and alkylene-O; E is selected from the group consisting of aryl, heteroaryl, cycloalkyl and heterocycloalkyl; m and n are independently selected from the group consisting of 0, 1, 2, 3 and 4; x and y are independently selected from the group consisting of 0 and 1; wherein any of A, B and E may be substituted with up to 4 substituents independently selected from the group consisting of hydroxy, F, Cl, Br, I, nitro, CN, alkyl, alkylhalo, O-alkyl, O-alkylhalo, alkenyl, O-alkenyl, alkynyl, O-alkynyl, alkyleneOR 2 , O-alkyleneOR 2 , (CO)R 2 , O(CO)R 2 , alkyleneO(CO)R 2 , alkylene(CO)R 2 , O-alkylene(CO)R 2 , CO 2 R 2 , alkyleneCO 2 R 2 , O-alkyleneCO 2 R 2 , alkylenecyano, O-alkylenecyano, O(CN)OR 2 , NR 2 R 3 , alkyleneNR 2 R 3 , O-alkyleneNR 2 R 3 , (CO)NR 2 R 3 , alkylene(CO)NR 2 R 3 , O—(CO)NR 2 R 3 , O-alkylene(CO)NR 2 R 3 , NR 2 (CO)R 3 , alkyleneNR 2 (CO)R 3 , O-alkyleneNR 2 (CO)R 3 , NR 2 (CO)NR 3 R 4 , alkyleneNR 2 (CO)NR 3 R 4 , and wherein R 2 and R 4 are independently selected from the group consisting of H and alkyl; R 3 is selected from the group consisting of H, alkyl and alkylene-NR 2 R 4 ; or a pharmaceutically acceptable salt thereof.