Patent ID: 8883806

Claim:
A process of preparing a composition comprising an enantiomeric excess of the (R)-enantiomer of a compound of Formula III′: comprising: (a) treating a compound of Formula XI′: with sodium hydride and 2-(trimethylsilyl)ethoxymethyl chloride to form a compound of Formula X″: (b) treating said compound of Formula X″ with a compound of Formula XIII′: in the presence of Pd(triphenylphosphine) 4 , potassium carbonate, and a solvent, to form a compound of Formula XII″: (c) reacting said compound of Formula XII″ under deprotection conditions to form a compound of Formula IV″: (d) reacting said compound of Formula IV″ with a compound of Formula D-1′: under conditions sufficient to form a composition comprising a racemate of a compound of Formula I″: (e) passing said composition comprising said racemate of said compound of Formula I″ through a chiral chromatography unit using a mobile phase and collecting a composition comprising an enantiomeric excess of the (R)-enantiomer of said compound of Formula I″; and (f) reacting said compound of Formula I″ with boron trifluoride diethyl etherate, followed by aqueous ammonium hydroxide to form a composition comprising an enantiomeric excess of the (R)-enantiomer of said compound of Formula III′; wherein * is a chiral carbon.