Patent ID: 7138377

Claim:
A compound according to the formula: or a stereoisomer or pharmaceutically acceptable addition salt or solvate thereof, wherein: X 1 , X 1′ , X 2 and X 2′ are independently at each occurrence selected from hydrogen, halogen, cyano, OR 6 , —CF 3 , alkylcarbonyl, C 1-7 alkyl, nitro, NR 6 R 7 , SR 6 , and C(O)OR 6 ; wherein said C 1-7 alkyl is optionally substituted with one or more substituents selected from halogen, CN, SR 6 , OR 6 , and NR 6 R 7 ; Z is NH, O, or S; R is hydrogen, OH, OC 1-7 alkyl, NH 2 , N(C 1-3 alkyl) 2 , or C 1-7 alkyl, wherein said C 1-7 alkyl is optionally substituted with one or more substituents selected from halogen, CN, SR 6 , OR 6 , and NR 6 R 7 ; R 1 is hydrogen, C 1-7 alkyl, C 3-7 cycloalkyl, halogen, azido, NR 6 R 7 , NHC(O)NR 6 R 7 , NHC(O)OR 6 , C(O)OR 6 , SR 6 , OR 6 , —OBenzyl, or oxo wherein said C 1-7 alkyl is optionally substituted with one or more substituents selected from halogen, CN, SR 6 , OR 6 , and NR 6 R 7 ; or R 1 and R 5 are taken together with the carbon to which they are attached to form a heterocycloalkyl having 3 members; R 2 , R 3 , and R 4 are independently at each occurrence selected from hydrogen, C 1-7 alkyl, C 3-7 cycloalkyl, halogen, azido, NR 6 R 7 , NHC(O)NR 6 R 7 , NHC(O)OR 6 , C(O)OR 6 , SR 6 , OR 6 , and —OBenzyl, wherein said C 1-7 alkyl is optionally substituted with one or more substituents selected from halogen, CN, SR 6 , OR 6 , and NR 6 R 7 ; R 5 is hydrogen, C 1-7 alkyl, C 3-7 cycloalkyl, halogen, azido, NR 6 R 7 , NHC(O)NR 6 R 7 NHC(O)OR 6 , C(O)OR 6 , OR 6 , or SR 6 , provided that at least one of R 1 , R 2 , R 3 , or R 4 is —OBenzyl when R 5 is hydrogen, wherein said C 1-7 alkyl is optionally substituted with one or more substituents selected from halogen, CN, SR 6 , OR 6 , and NR 6 R 7 ; or R 5 and R 1 are taken together with the carbon to which they are attached to form a heterocycloalkyl having 3 members; R 6 and R 7 are independently at each occurrence selected from hydrogen, C 1-7 alkyl, and C 3-7 cycloalkyl, wherein said C 1-7 alkyl is optionally substituted with one or more substituents selected from halogen, CN, OH, OC 1-3 alkyl, NH 2 , and N(C 1-3 alkyl) 2 ; or R 6 and R 7 together with the nitrogen atom to which they are attached form a non-aromatic 5–8 membered heterocycle containing one or two of the same or different heteroatoms selected from O, N, and S.