Patent ID: 7651999

Claim:
A 2′,5′-oligoadenylate analog represented by the formula (1): wherein m represents an integer of 0; n represents an integer of 0 or 1; R 1 represents an alkoxy group having from 1 to 6 carbon atoms substituted by a hydroxyl group, an unprotected mercapto group, an alkylthio group having from 1 to 4 carbon atoms substituted by a hydroxyl group, or a group of a formula X 1 —X 2 —X 3 —S—; R 2 , R 3 , R 4 , R 5 and R 6 independently represent an unprotected hydroxyl group, an unprotected mercapto group, an alkylthio group having from 1 to 4 carbon atoms substituted by a hydroxyl group, or a group of formula X 1 —X 2 —X 3 —S—; R 7 represents an oxygen atom a sulfur atom, —NH—, a —O(CH 2 CH 2 O)q- group, wherein g represents an integer of 2 to 6, or an oxyalkyleneoxy group having from 1 to 6 carbon atoms; R 8 represents a hydrogen atom, or a 5′-phosphorylated oligonucleotide analog which has one hydroxyl group removed from the 5′-phosphoric acid group; E 1 represents K 2 ; E 2 represents K 1 ; E 3 represents K 2 or K 3 and E 4 represents K 1 , K 2 or K 3 , wherein K 1 , K 2 and K 3 represent, respectively, wherein B represents an adeninyl group, A represents an alkylene group having from 1 to 4 carbon atoms, D represents an unsubstituted alkyl group having from 1 to 6 carbon atoms, or an unsubstituted alkenyl group having from 2 to 6 carbon atoms; X 1 represents an unsubstituted alkyl group having from 1 to 24 carbon atoms, or a phenyl group; X 2 represents a —C(═O)O—, —OC(═O)— or a —C(═O)S— group; and X 3 represents an unsubstituted alkylene group having from 1 to 6 carbon atoms, or a pharmacologically acceptable salt thereof.