Patent ID: 8414919

Claim:
A solid, monolithic sustained release pharmaceutical composition having an outer surface, the composition comprising: a. a sustained release matrix having a solvent accessible surface, the matrix comprising from about 20% to about 60% by weight of cross-linked high amylose starch; and b. an effective amount of at least one pharmaceutically active agent disposed within the matrix, the composition having a hardness in the range of from about 100 N to about 350 N, and the outer surface of the composition defining a score that permits the composition to be fractured along the score to produce at least two subunits, wherein at least one of the subunits and the composition from which it was derived have substantially the same release kinetics of the active agent disposed therein, and wherein at least one of the subunits created by fracturing the composition has a new solvent accessible surface that is capable of forming a barrier upon contact with a solvent.