Patent ID: 7786266

Claim:
An isolated antibody against desmocollin 2 (DSC2) showing effector function, wherein the antibody comprises complementarity determining regions (CDRs) selected from the group consisting of: group 1: FSSFGMH (SEQ ID NO: 26) as VH CDR1, YISSGSSTIYYADTVK (SEQ ID NO: 27) as VH CDR2, and VHYYYFDY (SEQ ID NO: 28) as VH CDR3; KASQDINKYIA (SEQ ID NO: 29) as VL CDR1, YTSTLQP (SEQ ID NO: 30) as VL CDR2, and LQYDNLW (SEQ ID NO: 31) as VL CDR3; group 2: DYSMH (SEQ ID NO: 32) as VH CDR1, WINTETGEPTYADDFKG (SEQ ID NO: 33) as VH CDR2, and WLLFDY (SEQ ID NO: 34) as VH CDR3; KSSQSLLNSSNQKNYLA (SEQ ID NO: 35) as VL CDR1, FASTRES (SEQ ID NO: 36) as VL CDR2, and QQHYSTPL (SEQ ID NO: 37) as VL CDR3; group 3: GNYWS (SEQ ID NO: 39) as VH CDR1, EINHSGNTKYNPSLKS (SEQ ID NO: 40) as VH CDR2, and VPFDWFHPPGEPPFYYYYGMDV (SEQ ID NO: 41) as VH CDR3; TGSSSNIGAGYDVH (SEQ ID NO: 44) as VL CDR1, GNSNRPS (SEQ ID NO: 45) as VL CDR2, and QSYDSSLSGWV (SEQ ID NO: 46) as VL CDR3; group 4: GYFWS (SEQ ID NO: 49) as VH CDR1, EINHSGSTSYNPSLKS (SEQ ID NO: 50) as VH CDR2, and GQGYYSSLDP (SEQ ID NO: 51) as VH CDR3; and SGSSSNIGSNTVN (SEQ ID NO: 53) as VL CDR1, SNNQRPS (SEQ ID NO: 54) as VL CDR2, and AAWDDSLNGVV (SEQ ID NO: 55) as VL CDR3; and wherein the CDR1, CDR2, and CDR3 are separated by framework amino acid sequences.