Patent ID: 7642284

Claim:
A compound having the structure of Formula I wherein n is 0, 1 or 2; R 1 is hydrogen or an aliphatic, heteroaliphatic, aryl or heteroaryl moiety; R 2 and R 3 are each independently hydrogen, or, when taken together, may be —O— or —(CH 2 ) q —, wherein q is 1, 2 or 3; R 4 is hydrogen, hydroxyl, protected hydroxyl or OR i , or an aliphatic or heteroaliphatic moiety, wherein R i is an aliphatic or heteroaliphatic moiety; R 5 is hydrogen, hydroxyl, protected hydroxyl or OR ii , or an aliphatic or heteroaliphatic moiety, wherein R ii is an aliphatic or heteroaliphatic moiety, or wherein R 1 and R 5 , when taken together, may form a cycloaliphatic or heterocycloaliphatic moiety comprising 6 to 12 atoms; R 6 is hydrogen, or an aliphatic, heteroaliphatic, aryl or heteroaryl moiety; R 7 is hydrogen, hydroxyl, protected hydroxyl, OR iii , or an aliphatic or heteroaliphatic moiety, wherein R iii is an aliphatic or heteroaliphatic moiety; R 8 is hydrogen, hydroxyl, protected hydroxyl or OR iv , wherein R iv is an aliphatic or heteroaliphatic moiety; R 9 is hydrogen, —CF 3 , —CHO, imine, hydrazone, oxime, carboxylic acid, carboxylic ester, acyl halide, ketone, amide, acetal, anhydride, dihalide, epoxide, nitrile or an aliphatic or heteroaliphatic moiety; R 11 and R 12 are each independently hydrogen, hydroxyl or OR v , or an aliphatic or heteroaliphatic moiety, or, when taken together, may be —(C═O), wherein R v is an aliphatic or heteroaliphatic moiety; and R 13 and R 14 are each independently hydrogen, or an aliphatic, heteroaliphatic, aryl or heteroaryl moiety; wherein each of the aliphatic and heteroaliphatic moieties may independently be substituted or unsubstituted, cyclic or acyclic, linear or branched, and wherein each of the aryl and heteroaryl moieties may be substituted or unsubstituted; with the proviso that when R 4 , R 5 , R 8 and R 10 are each hydroxyl, R 13 and R 14 are each methyl, R 2 and R 3 , taken together, form an epoxide, and n is 1, the following groups do not occur simultaneously as defined: R 1 is methyl, R 9 is hydrogen, (R 11 , R 12 ) is (═O) and R 6 is ethyl or isopropyl; R 1 is methyl, R 9 is CHO, (R 11 , R 12 ) is (OMe, H) and R 6 is ethyl, propyl or isopropyl; R 1 is methyl, R 9 is CHO, R 11 and R 12 are hydrogen and R 6 is ethyl, propyl or isopropyl; R 1 is methyl, R 9 is COCH 3 , R 11 and R 12 are hydrogen and R 6 is ethyl; and R 1 is ethyl, R 9 is CHO, R 11 and R 12 are hydrogen and R 6 is ethyl.