Patent ID: 7217709

Claim:
A compound of the Formula or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 5 is O, NH or S; R 6 is —H or C 1 –C 4 alkyl; X is —C(O)—, —CH 2 —, —CH(halo)-, —(C(OH)((CH 2 ) n CH 3 ))—, —(C(OH)(aryl))- or —CH(NR 11 R 12 )—, wherein n is an integer ranging from 0–5; R 11 and R 12 are independently -hydrogen or —C 1 –C 9 alkyl, or N, R 11 and R 12 are taken together to form a -(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or a -(nitrogen-containing 7- to 10-membered bicyclic heterocycle); R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 and R 10 are independently -hydrogen, -halo, -hydroxy, —C 1 –C 10 alkyl, halo-substituted-(C 1 –C 5 alkyl), —C 2 –C 10 alkenyl, —C 3 –C 8 -cycloalkyl, -aryl, —NH 2 , amino-substituted-(C 1 –C 5 alkyl), —C(O)OH, —C(O)O(C 1 –C 5 alkyl), —OC(O)(C 1 –C 5 alkyl), NO 2 or -A-B, wherein at least one of R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 and R 10 is other than hydrogen; A is —SO 2 —, —SO 2 NH—, —NHCO—, —NHCONH—, —O—, —CO—, —OC(O)—, —C(O)O—, —CONH—, —CON(C 1 –C 4 alkyl)-, —NH—, —CH 2 —, —S— or —C(S)—; B is —C 1 –C 10 alkyl, —C 2 –C 10 alkenyl, -(nitrogen-containing 3- to 7-membered monocyclic heterocycle), -(nitrogen-containing 7- to 10-membered bicyclic heterocycle), -(3- to 7-membered monocyclic heterocycle), -(7- to 10-membered bicyclic heterocycle), —C 3 –C 8 cycloalkyl, -aryl, —NZ 1 Z 2 , —(C 1 –C 5 alkylene)-NZ 1 Z 2 , amino-substituted-(C 1 –C 5 alkyl), —N(C 1 –C 5 alkyl)(C 1 –C 5 alkyl), —(C 1 –C 5 alkyl)-(3- to 7-membered monocyclic heterocycle), or —(C 1 –C 5 alkyl)-(7- to 10-membered bicyclic heterocycle), —(H 2 NC(O))-substituted aryl, —(H 2 NC(O))-substituted pyridyl, —C(O)OH, —C(O)O—(C 1 –C 5 alkyl), —C(O)O-phenyl or —C(NH)NH 2 , each of which is unsubstituted or substituted with one or more of —O—(C 1 –C 5 alkyl), -halo, halo-substituted-(C 1 –C 5 alkyl), HO-substituted-(C 1 –C 5 alkyl), amino-substituted-(C 1 –C 5 alkyl), -hydroxy, —NO 2 , —NH 2 , —CN, —NH(C 1 –C 5 alkyl), —N(C 1 –C 5 alkyl)(C 1 –C 5 alkyl), -(nitrogen-containing 3- to 7-membered monocyclic heterocycle), 7- to 10-membered bicycloheterocyclic amine, —C 1 –C 10 alkyl, —C 2 –C 10 alkenyl, —C 2 –C 10 alkynyl, -aryl, -benzyl, —(H 2 NC(O))-substituted(C 1 –C 5 alkyl), carboxy-substituted-(C 1 –C 5 alkyl), —C(O)OH, —C 1 –C 5 -alkylene-C(O)O—(C 1 –C 5 alkyl) or —C 1 –C 5 alkylene-OC(O)—(C 1 –C 5 alkyl), such that -A-B is other than —O—(C 1 –C 10 alkyl); and Z 1 and Z 2 are independently —H or —C 1 –C 10 alkyl, which is unsubstituted or substituted with one or more of -halo, —OH or —N(Z 3 )(Z 4 ), where Z 3 and Z 4 are independently, —H or —C 1 –C 5 alkyl, which is unsubstituted or substituted with one or more of -halo, -hydroxy or —NH 2 ; or N, Z 3 and Z 4 are taken together to form a -(nitrogen-containing 3- to 7-membered monocyclic heterocycle) or a -(nitrogen-containing 7- to 10-membered bicyclic heterocycle); or N, Z 1 and Z 2 are taken together to form a -(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or a -(nitrogen-containing 7- to 10-membered bicyclic heterocycle).