Patent ID: 7608278

Claim:
A non-painful immunogenic composition of a hydrophobic protein suitable for injection in a human comprising: (a) a hydrophobic protein; (b) an amount of a zwitterionic detergent that is less than the amount required to solubilize the protein; and (c) an amount of a pharmaceutically acceptable nonionic detergent effective to maintain solubility of the protein in a pharmaceutically acceptable carrier and, wherein the zwitterionic detergent is selected from the group consisting of n-Octyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; n-Decyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; n-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; n-Tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; 3-(N,N-n-Hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; 3-[(3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate; 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate; and n-Dodecyl-N,N-dimethylglycine.