Patent ID: 7309721

Claim:
A compound represented by Formula I: or a pharmaceutically acceptable salt or hydrate thereof, wherein: Ar is phenyl; m =1,2,3, or 4; n=1, 2, 3, or 4; X is a bond, O, NH or S(O) k , wherein k is 0, 1 or 2; A is selected from the group consisting of: —CO 2 H, —PO 3 H 2 , —PO 2 H 2 , —SO 3 H, —SO 2 CH 3 —PO(R 8 )OH, each R 1 is independently selected from the group consisting of: hydrogen, hydroxy, and C 1-4 alkyl, wherein said C 1-4 alkyl, is optionally substituted from one up to the maximum number of substitutable positions with halo, or when m is 2, 3, or 4, two R 1 groups on adjacent carbon atoms may be joined together to form a double bond; each R 3 is independently selected from the group consisting of: hydrogen, hydroxy, and C 1-4 alkyl, wherein said C 1-4 alkyl, is optionally substituted from one up to the maximum number of substitutable positions with halo, or when n is 2, 3, or 4, two R 3 groups on adjacent carbon atoms may be joined together to form a double bond; R 2 and R 4 are each independently selected from the group consisting of: hydrogen, hydroxy, and C 1-4 alkyl, wherein said C 1-4 alkyl, is optionally substituted from one up to the maximum number of substitutable positions with halo; or R 1 and R 2 or R 3 and R 4 residing on the same carbon atom may optionally be joined together to form a carbonyl group, each R 5 is independently selected from the group consisting of: halo, aryl, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio and C 3-6 cycloalkoxy, said C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio and C 3-6 cycloalkoxy optionally substituted from one up to the maximum number of substitutable positions with halo, R 8 is selected from the group consisting of: C 1-4 alkyl and aryl, wherein said C 1-4 alkyl is optionally substituted with 1-3 halo groups and aryl is optionally substituted with 1-5 substituents independently selected from the group consisting of: halo, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1-4 alkylthio and C 3-6 cycloalkoxy, said C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1-4 alkylthio and C 3-6 cycloalkoxy optionally substituted from one up to the maximum number of substitutable positions with halo, C is phenyl or C is not present; when C is not present then B is selected from the group consisting of: C 5-16 alkyl, C 5-16 alkenyl, C 5-16 alkynyl, and C 4-15 alkoxy, and when C is phenyl then B is C 1-6 alkyl.