Patent ID: 8263605

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is an optionally substituted aliphatic or —NR 6 R′ 6 ; Each of R 6 and R′ 6 is independently hydrogen or an optionally substituted C 1-4 aliphatic, or R 6 and R′ 6 together with the nitrogen atom to which they are attached form an optionally substituted 4-7 membered heterocycloaliphatic; L is a bond or an unsubstituted methylene group; R 2 is an optionally substituted bicyclic cycloaliphatic; or R 2 is a monocyclic cycloaliphatic optionally substituted with a heteroaryl; or R 2 is pyrrolidine-yl, 1,3-dioxolane-yl, imidazolidine-yl, 2-pyrazoline-yl, pyrazolidine-yl, piperidine-yl, 1,4-dioxane-yl, morpholine-yl, azepane-yl, azocane-yl, or piperazine-yl, each of which is optionally substituted with 1 to 3 of halo, or aliphatic, alkoxy, (aliphatic(oxy))carbonyl, (alkoxy(alkoxy))carbonyl, cycloaliphatic, heterocycloaliphatic, heteroaryl, amido, amino, (heterocycloaliphatic)oxy, or (heterocycloaliphatic(oxy))carbonyl, each of which is optionally substituted; or R 2 is an optionally substituted bicyclic heterocycloaliphatic that has 1-3 heteroatoms independently selected from N, O, and S; Each p is 0 or 1; and When p is 0, then R 1 is an optionally substituted C 2-8 alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, N,N-dimethylamino, or R 6 and R′ 6 together with the nitrogen atom to which they are attached form an optionally substituted 4-7 membered heterocycloaliphatic.