Patent ID: 7531502

Claim:
A diagnostic conjugate having the structure: transmembrane module (TPU) coupled via a spacer to an address module (AS) coupled via a spacer to a signalling module (SM); wherein the transmembrane module is a cell-penetrating human transmembrane peptide comprising the amino acid sequence KMTRQTWWHRIKHKC (SEQ ID NO: 2), MTRQTFWHRIKHKC (SEQ ID NO: 3) or KHKIRHWFTQRTMC (SEQ ID NO: 4), the address module is a peptide nucleic acid (PNA) antisense to and hybridizing with a mRNA selected from the group consisting of c-myc-, c-ras-, hern-, sst1, or sst2-mRNA, and the signalling module is a compound trapping Gadolinium.