Patent ID: 7109211

Claim:
A compound of Formula I′ wherein X is NR a ; wherein R a is selected from hydrido, C 1 –C 3 -alkyl, (optionally substituted phenyl)-C 1 –C 3 -alkyl, acyl and carboxy-C 1 –C 6 -alkyl; wherein R is selected from carboxyl, aminocarbonyl, C 1 –C 6 -alkylsulfonylaminocarbonyl and C 1 –C 6 -alkoxycarbonyl; wherein R″ is selected from hydrido, phenyl, thienyl and C 2 –C 6 -alkenyl; wherein R 1 is selected from C 1 –C 3 -perfluoroalkyl, chloro, C 1 –C 6 -alkylthio, C 1 –C 6 -alkoxy, nitro, cyano and cyano-C 1 –C 3 -alkyl; wherein R 2 is one or more radicals independently selected from hydrido, halo, C 1 –C 6 -alkyl, C 2 –C 6 -alkenyl, C 2 –C 6 -alkynyl, halo-C 2 –C 6 -alkynyl, aryl-C 1 –C 3 -alkyl, aryl-C 2 –C 6 -alkynyl, aryl-C 2 –C 6 -alkenyl, C 1 –C 6 -alkoxy, methylenedioxy, C 1 –C 6 -alkylthio, C 1 –C 6 -alkylsulfinyl, aryloxy, arylthio, arylsulfinyl, heteroaryloxy, C 1 –C 6 -alkoxy-C 1 –C 6 -alkyl, aryl-C 1 –C 6 -alkyloxy, heteroaryl-C 1 –C 6 -alkyloxy, aryl-C 1 –C 6 -alkoxy-C 1 –C 6 -alkyl, C 1 –C 6 -haloalkyl, C 1 –C 6 -haloalkoxy, C 1 –C 6 -haloalkylthio, C 1 –C 6 -haloalkylsulfinyl, C 1 –C 6 -haloalkylsulfonyl, C 1 –C 3 -(haloalkyl-C 1 –C 3 -hydroxyalkyl, C 1 –C 6 -hydroxyalkyl, hydroxyimino-C 1 –C 6 -alkyl, C 1 –C 6 -alkylamino, arylamino, aryl-C 1 –C 6 -alkylamino, heteroarylamino, heteroaryl-C 1 –C 6 -alkylamino, nitro, cyano, amino, aminosulfonyl, C 1 –C 6 -alkylaminosulfonyl, arylaminosulfonyl, heteroarylaminosulfonyl, aryl-C 1 –C 6 -alkylaminosulfonyl, heteroaryl-C 1 –C 6 -alkylaminosulfonyl, heterocyclylsulfonyl, C 1 –C 6 -alkylsulfonyl, aryl-C 1 –C 6 -alkylsulfonyl, optionally substituted aryl, optionally substituted heteroaryl, aryl-C 1 –C 6 -alkylcarbonyl, heteroaryl-C 1 –C 6 -alkylcarbonyl, heteroarylcarbonyl, arylcarbonyl, aminocarbonyl, C 1 –C 6 -alkoxycarbonyl, formyl, C 1 –C 6 -haloalkylcarbonyl and C 1 –C 6 -alkylcarbonyl; and wherein the A ring atoms A 1 , A 2 , A 3 and A 4 are independently selected from carbon and nitrogen with the proviso that at least two of A 1 , A 2 , A 3 and A 4 are carbon; or wherein R 2 together with ring A forms a radical selected from naphthyl, quinolyl, isoquinolyl, quinolizinyl, quinoxalinyl and dibenzofuryl; or an isomer or pharmaceutically acceptable salt thereof.