Patent ID: 8110653

Claim:
A collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises two or more consecutive repeat modules, wherein said repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of said repeat modules is derived from one or more repeat units and wherein said repeat units comprise framework residues, which contribute to the folding topology of said repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein said repeat proteins differ from other repeat proteins in said collection in at least one amino acid position of the repeat modules, and wherein said derivation of each of said repeat modules is carried out by an analysis comprising the steps of (a) identifying said repeat units; (b) determining a repeat sequence motif by structural and sequence analysis of said repeat units, wherein said structural and sequence analysis includes the identification of said framework residues and said target interaction residues of said repeat units; and (c) constructing the repeat module so that it comprises the repeat sequence motif of (b).