Patent ID: 7521068

Claim:
A dry powder aerosol composition for pulmonary or nasal delivery comprising spherically shaped aggregates formed from spray-drying aqueous dispersions of nanoparticulate drug particles, wherein: (a) the aqueous dispersions of nanoparticulate drug particles: (i) comprise a poorly soluble crystalline drug, wherein by “poorly soluble” it is meant that the drug has a solubility in at least one liquid dispersion medium of less than about 10 mg/ml, (ii) have an effective average particle size of less than about 1000 nm, meaning at least 50% of the drug particles have a particle size of less than about 1000 nm, and (iii) have a surface modifier adsorbed on the surface thereof; and (b) the aggregates of such spray-dried drug particle dispersions are less than or equal to about 100 microns in diameter; and (c) such aggregates return to nanoparticulate drug particle dispersions upon reconstitution in an aqueous liquid medium.