Patent ID: 7521448

Claim:
A compound represented by Formula (I): wherein: one of R11, R12, R13 and R14 is —NR 3 COR 31 , —NR 3 CONR 3 R 31 , —NR 3 SO 2 R 31 , —CO 2 R 3 , —CO 2 H, —C 0-8 alkylNR 3 R 31 or —CONR 3 R 3 R 31 ; and the others are each independently F, Cl, Co 0-3 alkyl, C 0-8 alkoxy, or —N(C 0-8 alkyl)(C 0-8 alkyl); X is phenyl, optionaily substituted with 1-4 of halogen, —NR 32 R 33 , —NR 32 COR 33 , —NR 32 CO2R 33 , —NR 32 SO 2 R 33 , —OR 32 , SR 32 , —SO 2 R 32 , —SO 2 NR 32 R 33 , —CO 2 R 32 , —CO 2 H, —CONR 32 R 33 , —C 0-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, —CN, CF 3 , OCF 3 , NO 2 , or oxo; Y is wherein the point of attachment to X can be from either the left or the right as shown; R a and R b , are each independently C 0-8 alkyl or C 3-8 cycloallcyl; or R a and R b , taken together with the C to which they are attached form a saturated or partially unsaturated 3-10 membered ring; n is 1, 2, 3, 4 or 5; Z is phenyl, optionally substituted with 1-5 independent halogen, —NR 34 R 35 , —NR 34 COR 35 , —NR 34 C(O)OR 35 , —NR 34 SO 2 R 35 , —OR 34 , —SR 34 , —SO 2 R 34 , —SO 2 NR 34 R 35 , —C(O)OR 34 , —CO 2 H, —CONR 34 R 35 , C 0-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, —OC 0-8 alkyl, —SC 0-8 alkyl, —SO 2 C 0-8 alkyl, —SO 2 N(C 0-8 alkyl)(C 0-8 alkyl), —C(O)OC 0-8 alkyl, CN, CF 3 , NO 2 , oxo, carbocyclyl, C 0-8 alkyl-O—C 0-8 alkyl, C 0-8 alkyl-O—C(O)—C 0-8 alkyl, or C 0-8 alkyl-C(O)-O—C 0-8 alkyl; R 3 , R 34 , and R 35 are independently —CF 3 , —CHF 2 , —C 0-8 alkyl-O—C 0-8 alkyl, —C 0-8 alkyl-N(C 0-8 alkyl)(C 0-8 alkyl), —C 0-8 alkyl-S(O) 0-2 —C 0-8 alkyl, —C 0-8 alkyl-S(O) 2 N(C 0-8 alkyl)(C 0-8 alkyl), or C 0-8 alkyl optionally substituted with OH; R 31 is C 0-8 alkyl substituted by morpholinyl; R 32 and R 33 are independently —CF 3 , —CHF 2 , —C 0-8 alkyl-O—C 0-8 alkyl, C 0-8 alkyl-N(C 0-8 alkyl)(C 0-8 alkyl), C 0-8 alkyl-S(O) 0-2 —C 0-8 alkyl, or —C 0-8 alkyl-S(O) 2 N(C 0-8 alkyl)(C 0-8 alkyl); provided that when Y is —OCH 2 —, Z must be substituted with 1-5 —NR 34 R 35 , —NR 34 COR 35 , —NR, 34 C(O)OR 35 , —NR 34 SO 2 R 35 , —OR 34 , —SR 34 , —SO 2 R 34 , —SO 2 NR 34 R 35 , —CO 2 R 34 , —CO 2 H, —CONR 34 R 35 , C 0-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, CF 3 , NO 2 , oxo, or carbocyclyl substituents optionally substituted with OH; or a pharmaceutically acceptable salt or N-oxide thereof.