Patent ID: 7797302

Claim:
A computer program storage device readable by a machine and containing a set of instructions which, when read by the machine, causes execution of a bioinformatics method for generating a compilation containing combinations of pangenetic and non-pangenetic attributes that co-associate with a query attribute associated with an individual, comprising: a) receiving a query attribute which identifies, within a computer memory, a set of query-attribute-positive attribute profiles associated with query-attribute-positive individuals and a set of query-attribute-negative attribute profiles associated with query-attribute-negative individuals, wherein the attribute profiles comprise pangenetic attributes and non-pangenetic attributes; b) accessing attribute profiles of query-attribute-positive individuals and attribute profiles of query-attribute-negative individuals, wherein the attribute profiles comprise pangenetic attributes and non-pangenetic a query-attribute-positive attribute profile from the set of query-attribute-positive attribute profiles and a subset of query-attribute-negative attribute profiles from the set of query-attribute-negative attribute profiles; c) determining a set of candidate attributes comprising attributes from the query-attribute-positive attribute profile of one query-attribute-positive individual that do not occur in the attribute profiles of at least a predetermined portion of the subset of query-attribute-negative individuals attribute profiles; d) determining the frequencies of occurrence of combinations of candidate attributes in the set of attribute profiles of the query-attribute-positive attribute profiles individuals and in the set of attribute profiles of the query-attribute-negative attribute profiles individuals, wherein each of the combinations of candidate attributes contains at least one pangenetic attribute and at least one non-pangenetic attribute selected from the set of candidate attributes; and e) storing, within a computer memory, the combinations of candidate attributes having higher frequencies of occurrence in the set of attribute profiles of the query-attribute-positive attribute profiles individuals than in the set of attribute profiles of the query-attribute-negative attribute profiles individuals to generate a compilation of attribute combinations that co-associate with the query attribute; and f) storing, in the compilation, corresponding statistical results that are computed based on the frequencies of occurrence to indicate the strength of association of each of the attribute combinations in the compilation with the query attribute; g) repeating steps (b)-(f) for one or more successive attribute profiles contained in the set of query-attribute-positive attribute profiles.