Patent ID: 8846687

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are each independently selected from H and C 1 -C 6 alkyl; Y is selected from —C(O)C 3 -C 8 cycloalkyl and —C(O)C 1 -C 3 alkyl-C 3 -C 8 cycloalkyl, where the cycloalkyl rings are each optionally substituted by one or more substituents selected from List X; A is N; Ar′ is a group wherein E is CR e ; R a is selected from H, halo, and C 1 -C 6 alkyl; R b is selected from H, halo, and C 1 -C 6 alkyl; R e is (CH 2 ) c S(O) 2 R 45 ; R d is H; R e is selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl and halo; R 42 is selected from H and C 1 -C 6 alkyl; R 43 is selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, and C 1 -C 3 alkyl-C 3 -C 6 cycloalkyl, wherein the cycloalkyl rings are each optionally substituted by one or more substituents selected from —OH and —NH 2 ; R 45 is selected from —NR 42 R 43 and a 5- to 7-membered nitrogen-containing heterocyclic group which is optionally substituted by one or more groups selected from —OH, C 1 -C 3 alkyl, and C 1 -C 3 hydroxyalkyl; c is 0, 1 or 2; and List X is represented by hydroxy, halo, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 8 cycloalkyl, C 1 -C 3 alkyl-C 3 -C 8 cycloalkyl, and —OC 1 -C 6 -alkyl, where each of the hydrocarbon groups are optionally substituted by one or more halogen, hydroxy, —OC 1 -C 6 -alkyl, or cyano substituents.