Patent ID: 6864366

Claim:
Process for the preparation of (E)-5-(2-bromovinyl)-2′-β-deoxyuridine of formula I comprising: a) reaction of a compound of formula II, in which R is an alkanoyl C1-C8 group, a benzoyl group or a benzoyl group substituted at the para position with a C1-C4 alkyl group or with a halogen atom, with a brominating agent in the presence of a radical initiator, in a halogen-free solvent selected from an alkyl ester or a cyclic ether; b) dehydrobromination of the resulting compound of formula (III) wherein R has the above defined meaning, with or without bases, in a halogen-free solvent to give an intermediate of formula (IV), wherein R has the above defined meaning; c) deprotection of the intermediate of formula (IV).