Patent ID: 6946446

Claim:
A method of inhibiting the activity of methicillin-resistant bacteria in a mammal, comprising administering to the mammal an effective amount of a compound of the formula a compound of the formula a compound of the formula wherein R 1 is selected from the group consisting of a hydrocarbon selected from the group consisting of C 1 -C 12 alkyl, C 3 -C 12 alkenyl, and C 3 -C 12 alkynyl, wherein 1 to 3 carbons of said hydrocarbon are optionally replaced by an O, S or N heteroatom or a group selected from the group consisting of —C(O)—, —C═N—, —C═N—O— and —N(R 5 )—; and wherein said hydrocarbon is optionally substituted with one to three substituents selected from the group consisting of —C(O)R 6 , —S(O) n R 6 , —NHC(O)R 6 , —NHC(O)NR 7 R 8 , halogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl and heterocycloalkyl, wherein n is 1 or 2; R 2 is selected from the group consisting of (a) hydrogen, (b) a hydrocarbon selected from the group consisting of C 1 -C 12 alkyl, C 3 -C 12 alkenyl, and C 3 -C 12 alkynyl, wherein 1 to 3 carbons of said hydrocarbon are optionally replaced by an O, S or N heteroatom or a group selected from the group consisting of —C(O)—, —C═N—, —C═N—O— and —N(R 5 )—; and wherein said hydrocarbon is optionally substituted with one to three substituents selected from the group consisting of —C(O)R 6 , —S(O) n R 6 , —NHC(O)R 6 , —NHC(O)NR 7 R 8 , halogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl and heterocycloalkyl; (c) optionally substituted aryl; and (d) optionally substituted heteroaryl; R 3 is selected from the group consisting of (a) —H, (b) —OH, (c) —OC(O)R 9 , (d) —OC(O)NHR 9 , and (e) —OC(O)OR 9 ; R 4 selected from the group consisting of (a) —H, (b) —C(O)R 9 , (c) —C(O)NHR 9 , and (d) —C(O)OR 9 ; R 5 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with optionally substituted aryl or optionally substituted heteroaryl, optionally substituted aryl, or optionally substituted heteroaryl; R 6 is hydrogen, alkyl optionally substituted with aryl or heteroaryl, optionally substituted aryl, or optionally substituted heteroaryl; R 7 and R 8 are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with optionally substituted aryl or heteroaryl, optionally substituted aryl, or optionally substituted heteroaryl, or R 7 and R 8 taken together with the atoms to which they are attached form a C 3 -C 12 cycloalkyl group; and R 9 is a hydrocarbon selected from the group consisting of C 1 -C 12 alkyl, C 3 -C 12 alkenyl, and C 3 -C 12 alkynyl, wherein 1 to 3 carbons of said hydrocarbon are optionally replaced by an O, S or N heteroatom, or a group selected from the group consisting of —C(O)—, —C═N—, —C═N—O— and —N(R 5 )—; and wherein said hydrocarbon is optionally substituted with one to three substituents selected from the group consisting of —C(O)R 6 , —S(O) n R 6 , —NHC(O)R 6 , —NHC(O)NR 7 R 8 , halogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl and heterocycloalkyl.