Patent ID: 7381707

Claim:
A method to treat dry eye in a mammal in need of such treatment comprising intraocularly administering to said eye a composition comprising a carrier and a peptide of the formula wherein: A 1 is Val, Leu, Ile, or Cha; A 2 is Val, Leu, Ile, or Cha; A 3 is Gly or Ala; A 4 is Lys, Arg, or Har; each R 1 and R 2 , independently, is H, C 1-12 alkyl, C 7-10 phenylalkyl, or C(═O)E 1 , where E 1 is C 1-20 alkyl, C 3-20 alkenyl, C 3-20 alkynyl, phenyl, 3,4-dihydroxyphenylalkyl, naphthyl, or C 7-10 phenylalkyl; provided that when either R 1 or R 2 is C(═O)E 1 , the other must be H; and R 3 is OH, NH 2 , C 1-12 alloxy, C 7-10 phenylalkoxy, C 11-20 naphthylalkoxy, C 1-12 alkylamino, C 7-10 phenylalkylamino, or C 11-20 naphthylalkylamino; or a cosmetically acceptable salt thereof.