Patent ID: 8030489

Claim:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof: wherein: A represents cycloalkanediyl, X represents a single bond, —O—, —NH—, or —NR 0 —, Y represents a single bond, —R 00 —, or —Y 1 —R 00 —, Y 1 represents —O—, —S—, —S(O)—, —S(O) 2 —, or —NHS(O) 2 —, R 1 represents —CO 2 H, —CO 2 —(C 1-4 alkyl), —CO—NH—SO 2 —(C 1-4 alkylene)-OH, or tetrazol-5-yl, R 2 represents —R 0 , —C(O)—R 0 , —R 21 , or —C(O)—R 21 , R 21 represents phenyl, pyridyl, pyrrolyl, pyrazolyl, indolyl, imidazopyridyl, quinolyl, benzofuryl, or -(lower alkenylene)-(phenyl), each of which may be substituted with a member selected from the group consisting of —R 0 , —OH, —OR 0 , halogen, acetyl, and —N(R 0 ) 2 , R 3 represents —R 0 , -(aryl which may be substituted), -(cycloalkyl which may be substituted), —R 00 -(aryl which may be substituted), or —R 00 -(cycloalkyl which may be substituted), wherein the substituent, if present, is a member selected from the group consisting of —R 0 , —R 00 —OH, —R 00 —OR 0 , —OH, —OR 0 , —O—R 00 —OH, —O—R 00 —O-(hetero ring), —O—C(O)—R 00 , halogen, oxo, —NR 0 2 , —NH—SO 2 —R 0 , —NR 0 —CO—R 0 , —NH—R 00 —OR 0 , —NR 0 —R 00 —OR 0 , —CO—R 0 , —SO 2 —R 0 , -(lower alkenyl), phenyl, pyrrolidinyl, pyrrolyl which may be substituted with a lower alkyl group, pyrazolyl, piperidinyl, and piperazinyl, R 4 and R 5 each represent H or R 0 , R 0 represents lower alkyl, and R 00 represents lower alkylene.