Patent ID: 7403812

Claim:
A method of investigating the location and light intensity of a light-emitting source in a subject, comprising: (a) obtaining a first measured light intensity profile that was constructed by measuring, from a first perspective in a dark imaging chamber with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject; (b) fitting said first measured light intensity profile with a parameter-based biophotonic function to obtain an initial determination of the location and light intensity of the light-emitting source; and (c) refining the parameters of the biophotonic function, using data in addition to said first measured light intensity profile, to improve the initial determination of the location and light intensity to obtain a refined location and light intensity of the source in the subject.