Patent ID: 7361663

Claim:
A compound of Formula (I) wherein is a single or double bond R 1 is hydrogen, —CO 2 R 3 , —C(O)R 3 , —CONR 3 R 3 , —CH 2 OR 4 or —CH 2 SR 4 ; ring A is an optionally substituted pyrrolidinyl ring; R 2 is alkyl, alkenyl, alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heterocyclenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, optionally substituted aralkenyl, optionally substituted heteroaralkenyl, optionally substituted aralkynyl, or optionally substituted heteroaralkynyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkyl, lower acyl, aroyl or heteroaroyl; and Z 1 is optionally substituted phenyl and is additionally substituted by an amidino group of formula wherein R 5 and R 6 together are ═NR 8 ; R 8 is selected from hydrogen, R 9 O 2 C—, R 9 O—, HO—, R 9 C(O)—, HCO—, cyano, optionally substituted lower alkyl, nitro or Y 1a Y 2a N—; wherein R 9 is alkyl, optionally substituted aralkyl, or optionally substituted heteroaralkyl; R 7 is selected from hydrogen, optionally substituted lower alkyl, optionally substituted aralkyl and optionally substituted heteroaralkyl; and Y 1a and Y 2a are independently hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, an N-oxide thereof, or an acid bioisotere thereof selected from the group consisting of C(═O)—NHOH, C(═O)—NH—CN, sulpho, phosphono, alkylsulfonylcarbamoyl, tetrazolyl, arylsulfonylcarbamoyl, heteroarylsulfonylcarbamoyl, N-methoxycarbamoyl, 3-hydroxy-3-cyclobutene-1,2-dione, 3,5-dioxo-1,2,4-oxadiazolidinyl, or 3-hydroxyisoxazolyl, 3-hydroxy-1-methylpyrazolyl or other heterocyclic phenols.