Patent ID: 8263597

Claim:
A compound of the formula (I) wherein Ar 1 is heteroaryl or heterocycle each optionally substituted by one to three R a ; X 1 is a —(CH 2 ) n — wherein one or more hydrogen atoms can be replaced by R a ; X 2 is Ar 2 , —S(O) m —Ar 2 or —S(O) m NR e R f or —S(O) m NH—Ar 2 ; Ar 2 is carbocycle, heteroaryl or heterocycle each optionally substituted by one to three R b ; R 1 is hydrogen, C 1-6 alkyl or C 1-6 alkoxyC 1-6 alkyl; R 2 , R 3 are each independently hydrogen or C 1-6 alkyl optionally substituted by R a ; R a is C 1-6 alkyl, C 3-10 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 1-6 alkoxycarbonyl, amino, mono- or di-C 1-6 alkylamino, C 3-6 cycloalkylamino, C 1-6 alkylaminocarbonyl, C 1-6 acyl, C 1-6 acylamino, C 1-6 dialkylaminocarbonyl, hydroxyl, halogen, cyano, nitro, oxo, R 4 —S(O) m —NH—, R 4 —NH—S(O) m —, aryl or carboxyl; R b is hydroxyl, carboxyl, halogen, —(CH 2 ) n —CN, nitro, oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-6 alkoxy, C 1-6 alkoxycarbonyl, —(CH 2 ) n —NR c R d , R 4 —S(O) m —, R 4 —S(O) m —NR e —, R 4 —NR e —S(O) m —, —NR f —C(O)—R e , —(CH 2 ) x —C(O)—(CH 2 ) n —NR c R d , heterocyclyl, aryl or heteroaryl, each substituent on R b where possible is optionally halogenated or substituted with 1 to 3 C 1-6 alkyl, C 1-6 acyl, C 1-6 alkoxycarbonyl, C 1-6 alkyl-S(O) m —, aryl or carboxyl; each R c , R d are independently hydrogen, C 1-6 alkyl, C 1-6 acyl, C 3-10 cycloalkyl, C 1-6 alkoxy, hydroxyC 1-6 alkyl, C 1-6 alkylC 1-6 alkoxy, C 1-6 alkylsulfonyl, C 1-6 alkoxycarbonyl or —(CH 2 ) n —NR e R f ; each R e , R f are independently hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl, C 1-6 alkoxy, hydroxyC 1-6 alkyl or C 1-6 acyl; R 4 is hydrogen, C 1-6 alkyl, heterocyclyl, aryl or heteroaryl each optionally substituted with C 1-6 alkyl, C 1-6 alkoxy, halogen, hydroxyl, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkoxycarbonyl or C 1-6 acylamino; R 5 is hydrogen or R a ; R x is hydrogen or halogen; each n, x are independently 0-3; each m is independently 0-2; or a pharmaceutically acceptable salt thereof.