Patent ID: 7939632

Claim:
A fusion protein comprising: a) a coagulation factor, b) a half-life enhancing polypeptide (HLEP) wherein the half-life enhancing polypeptide is, and c) a peptide linker which joins the coagulation factor and the half-life enhancing polypeptide; wherein the peptide linker is cleavable by proteases involved in coagulation, and wherein the fusion protein has, in comparison to a respective fusion protein linked by a non-cleavable linker having the amino acid sequence GGGGGGV (SEQ ID NO: 94), at least one of the following properties: i) an increased molar specific activity in at least one coagulation-related assay, ii) an increased inactivation rate of the activated coagulation factor after the peptide linker is proteolytically cleaved in a coagulation-related mode, and iii) an increased elimination rate of the activated coagulation factor after the peptide linker is proteolytically cleaved in a coagulation-related mode.