Patent ID: 7700614

Claim:
A method of preparing a molecule of formula I: comprising: (a) reacting a molecule of formula II: with triflic anhydride to produce a molecule of formula III: (b) reacting the molecule of formula III with a molecule of formula IV: and (c) providing an antioxidant, wherein R 1 is selected from the group consisting of ═O, and (H, OH); R 2 and R 5 are independently selected from the group consisting of H, —C(═O)R 6 , —C(═O)OR 6 , —C(═O)NHR 6 , and —C(═S)OR 6 ; R 3 is selected from the group consisting of ═O and OR 5 ; or R 2 and R 3 can be taken together to form moiety of formula A—C(R 7 )(R 8 )—O—B, where A is a bond to oxygen bonded to carbon 28 and B is a bonded to carbon 28 as defined above; R 4 is selected from the group consisting of H and C 1 -C 4 alkyl; R 6 is selected from the group consisting of C 1 -C 10 alkyl, C 3 -C 6 cycloalkyl, aryl groups, and heterocyclic groups; R 7 and R 8 are independently selected from the group consisting of H, C 1 -C 6 alkyl, or R 7 and R 8 taken together are ═O R 9 and R 10 are independently selected from the group consisting of H, alkenyl, alkenylcycloalkenyl, alkenylcycloalkyl, alkyl, alkylcycloalkenyl, alkylcycloalkyl, alkynyl, aralkyl, aryl, cycloalkenyl, cycloalkyl, cycloalkylalkyl, cycloalkylcycloalkyl, cycloalkenylalkyl, and heterocyclyl, wherein the reactions are performed in a single pot, wherein the antioxidant is selected from the group consisting of 3,5-di-tert-4-butylhydroxy toluene (BHT), 2,6-di-t-butyl-4-ethylphenol (DEP), 2,6-di-t-butyl-4-methoxylphenol (DMP), DL-α-tocopherol, propyl gallate, ascobyl palmitate, 3-tert-butyl-4-hydroxyanisole, 2-tert-butyl-4-hydroxyanisole, fumaric acid, and combinations thereof.