Patent ID: 7348318

Claim:
An α-amino-N-(diaminophosphinyl)lactam compound represented by the following general formula (1), or a pharmacologically acceptable salt thereof: wherein A is a hydrogen atom, a lower alkyl group, an aryl group, a heteroaryl group, a lower alkenyl group or a cycloalkyl group, each of these groups being able to be substituted by a lower alkyl group, an aryl group, a heteroaryl group, a lower alkoxy group, a hydroxyl group, a halogen atom, an amino group, a lower alkylamino group, a di-lower alkylamino group, an arylamino group, a heteroarylamino group, a lower acylamino group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group or a lower alkylaminocarbonyl group; W, X, Y and Z are independently a hydrogen atom, a lower alkyl group, an aryl group, a heteroaryl group, a lower alkenyl group, a cycloalkyl group, a lower acyl group, an arylacyl group, a heteroarylacyl group, a lower alkylaminocarbonyl group or an arylaminocarbonyl group, each of these groups being able to be substituted by a lower alkyl group, an aryl group, a heteroaryl group, a lower alkoxy group, an aryloxy group, a hydroxyl group, an amino group, a lower alkylamino group, a di-lower alkylamino group, a lower acylamino group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, a cyano group, a nitro group, a carbamoyl group or a lower alkylaminocarbonyl group, or one or both of a combination of W and X and a combination of Y and Z form a cyclic group (s) through a saturated or unsaturated carbon-carbon bond or a saturated or unsaturated carbon-carbon bond containing 1 to 3 heteroatoms selected from nitrogen atom, oxygen atom and sulfur atom, said cyclic group (s) being able to be unsubstituted or substituted by a substituent (s) selected from the group consisting of lower alkyl groups, aryl groups, heteroaryl groups, halogen atoms, nitro group, cyano group, lower alkoxycarbonyl groups, carbamoyl group, lower alkylaminocarbonyl groups and carboxyl group, and W and X, or Y and Z, which do not form a ring, have the above-mentioned substituent; and Q is —(CH 2 ) n — wherein n is 0 to 3.