Patent ID: 6908901

Claim:
A racemate, diastereoisomer, or optical isomer of a compound of formula (I): wherein: B is (C 2-10 )alkyl, (C 3-7 )cycloalkyl or (C 1-4 )alkyl-(C 3-7 )cycloalkyl, a) wherein said cycloalkyl and alkyl-cycloalkyl may be mono-, di- or tri-substituted with (C 1-3 )alkyl; and b) wherein said alkyl, cycloalkyl and alkyl-cycloalkyl may be mono- or di-substituted with substituents selected from hydroxy and O—(C 1-4 )alkyl; and c) wherein each of said alkyl groups may be mono-, di- or tri-substituted with halogen; and d) wherein in each of said cycloalkyl groups being 5-, 6- or 7-membered, one or two —CH 2 -groups not being directly linked to each other may be replaced by —O— such that the O-atom is linked to the N atom to which B is attached via at least two C-atoms; or B is phenyl, (C 1-3 )alkyl-phenyl, heteroaryl or (C 1-3 )alkyl-heteroaryl, wherein the heteroaryl-groups are 5- or 6-membered having from 1 to 3 heteroatoms selected from N, O and S; wherein said phenyl and heteroaryl groups may be mono-, di- or trisubstituted with substituents selected from halogen, —OH, (C 1-4 )alkyl, O—(C 1-4 )alkyl, S—(C 1-4 )alkyl, —NH 2 , —NH((C 1-4 )alkyl) and —N((C 1-4 )alkyl) 2 , —CONH 2 and —CONH—(C 1-4 )alkyl; Y is H or (C 1-6 )alkyl; R 3 is (C 1-6 )alkyl, (C 3-7 )cycloalkyl or (C 1-3 )alkyl-(C 3-7 )cycloalkyl, wherein each of said cycloalkyl groups may be mono-, di- or tri-substituted with substituents selected from halogen, —OH, (C 1-4 )alkyl, O—(C 1-4 )alkyl, S—(C 1-4 )alkyl, —NH 2 , —NH((C 1-4 )alkyl), —N((C 1-4 )alkyl) 2 , —COOH and —CONH 2 ; R 2 is R 20 , —NR 21 R 22 , —NR 22 COR 20 , —NR 22 COOR 20 or —NR 22 CONR 23 R 21 , wherein R 20 is selected from (C 1-8 )alkyl, (C 3-7 )cycloalkyl and (C 1-4 )alkyl-(C 3-7 )cycloalkyl, wherein said alkyl, cycloalkyl and alkyl-cycloalkyl may be mono-, di- or tri-substituted with (C 1-3 )alkyl; and R 21 is H or R 20 , R 22 and R 23 are independently selected from H and methyl, and R 24 is selected from —O—(C 1-4 )alkyl, —NH((C 1-4 )alkyl) and —N((C 1-4 )alkyl) 2 ; R 1 is (C 1-6 )alkyl or (C 2-6 )alkenyl; and R C is hydroxy or NHSO 2 R S wherein R S is (C 1-6 )alkyl, (C 3-7 )cycloalkyl, (C 1-6 )alkyl-(C 3-7 )cycloalkyl, phenyl, naphthyl, pyridinyl, (C 1-4 )alkyl-phenyl, (C 1-4 )alkyl-naphthyl or (C 1-4 )alkyl-pyridinyl; all of which optionally being mono-, di- or tri-substituted with substituents selected from halogen, hydroxy, cyano, (C 1-4 )alkyl, O—(C 1-6 )alkyl, —CO—NH 2 , —CO—NH((C 1-4 )alkyl), —CO—N((C 1-4 )alkyl) 2 , —NH 2 , —NH((C 1-4 )alkyl) and —N((C 1-4 )alkyl) 2 , wherein (C 1-4 )alkyl and O—(C 1-6 )alkyl are optionally mono-, di- or trisubstituted with halogen; and all of which optionally being monosubstituted with nitro; or a pharmaceutically acceptable salt or ester thereof.