Patent ID: 7915405

Claim:
A 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole compound represented by the following formula 1: wherein R 1 and R 2 are independently selected from the group consisting of a C 1 -C 10 linear alkyl group, a C 3 -C 10 branched alkyl group, and a C 1 -C 10 linear alkyl group substituted with a C 3 -C 10 cycloalkyl group, or R 1 and R 2 together with the nitro en atom to which the are attached form a C 3 -C 10 heterocyclic group containing one or more heteroatoms independently selected from N, S and O; R 3 is a carbonyl group substituted with at least one group selected from the group consisting of a C 1 -C 10 linear alkyl group, a C 3 -C 10 branched alkyl group, a C 3 -C 10 cyclic group, a C 1 -C 10 alkoxy group, a C 2 -C 10 alkenyl group, a C 2 -C 10 alkynyl group, a heteroaryl group, an arylalkyl group, a C 5 -C 10 heteroarylalkyl group, and a phenyl or substituted phenyl group; and R 4 is selected from the group consisting of piperidinyl, morpholino, 4-methoxybenzylamino, piperidin-1-yl-ethylamino, pyrrolidin-1-ylethylamino, 2-morpholinoethylamino, 2-morpholinopropylamino, 4-morpholinopiperidin-1-yl, 4-pyrrolidin-1-ylpiperidin-1-yl, 1,4′-bipiperidin-1′-yl, cyclopropylmethylamino, cyclohexylmethylamino, or R 4 is —NR a R b wherein R a and R b are independently selected from the group consisting of a hydrogen, C 1 -C 10 linear alkyl group, a C 3 -C 10 branched alkyl group, a C 3 -C 10 cyclic group, an aryl group, a heteroaryl group, an aryl(C 1 -C 10 )alkyl group a heteroaryl(C 1 -C 10 )alkyl group, or R 4 is a piperazinyl substituted with a group selected from the group consisting of C 1 -C 10 linear alkyl group, a C 3 -C 10 branched alkyl group, a C 3 -C 10 cyclic group, a phenyl or substituted phenyl group, and a heteroaryl group, wherein the substituted phenyl group in R 3 and R 4 represents a phenyl group substituted with 1 to 4 substituents independently selected from the group consisting of a halogen atom, a cyano group, a C 1 -C 10 alkyl group, and a C 1 -C 10 alkoxy group, or a pharmaceutically acceptable salt thereof.