Patent ID: 7754729

Claim:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein, X represents N; Y represents CH 2 , S, O or N—R 9 ; R 1 , R 3 , R 7 and R 8 independently represent H, CF 3 , or C 1-6 alkyl; R 2 represents a substituent of a formula selected from formulas (II), (III), (IV), (V), (VI), (VII), or (VIII); R 4 and R 6 independently represent H, C 1-6 alkyl, OC 1-6 alkyl, OH, F, Cl, Br, OCF 3 , or trifluoromethyl; R 5 is independently at each occurrence selected from H, F, C 1-6 alkyl, OH, OC 1-6 alkyl, OCF 3 , OCF 2 CH 3 , NH 2 , NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , 1-pyrrolinyl, 1-piperidyl, 4-morpholinyl, Cl, Br, trifluoromethyl, O(CH 2 ) 2-4 OC 1-6 alkyl, O(CH 2 ) 2-4 OCF 3 , O(CH 2 ) 2-4 NH(C 1-6 alkyl), O(CH 2 ) 2-4 N(C 1-6 alkyl) 2 , (1-pyrrolinyl)(CH 2 ) 2-4 O, (1-piperidyl)(CH 2 ) 2-4 O, (4-morpholinyl)(CH 2 ) 2-4 O, NHC(O)H, NHC(O)(C 1-6 alkyl), N(C 1-6 alkyl)C(O)(C 1-6 alkyl), O(CH 2 ) 2-4 OH, N(C 1-6 alkyl)C(O)O(C 1-6 alkyl), N(C 1-6 alkyl)C(O)OH, NHC(O)O(C 1-6 alkyl), OC(O)NH(C 1-6 alkyl), OC(O)N(C 1-6 alkyl) 2 , (1-piperidyl)(CH 2 ) 2-4 OC(O), (4-morpholinyl)(CH 2 ) 2-4 OC(O), (1-pyrrolinyl)(CH 2 ) 2-4 OC(O), (1-imidazolyl)(CH 2 ) 2-4 O, (pyrazolyl)(CH 2 ) 2-4 O, (triazolyl)(CH 2 ) 2-4 OC(O), or Ar(CH 2 ) 1-4 O; R 9 is independently at each occurrence selected from H, C 1-6 alkyl, CF 3 , CF 2 CH 3 , (CH 2 ) 2-4 OH, (CH 2 ) 1-4 OC 1-6 alkyl, (CH 2 ) 1-4 NH(C 1-6 alkyl), (CH 2 ) 1-4 N(C 1-6 alkyl) 2 , (1-pyrrolinyl)(CH 2 ) 1-4 , (1-piperidyl)(CH 2 ) 1-4 , (4-morpholinyl)(CH 2 ) 1-4 , C(O)C 1-6 alkyl, C(O)(CH 2 ) 1-4 OH, C(O)(CH 2 ) 1-4 OC 1-6 alkyl, C(O)(CH 2 ) 1-4 N(C 1-6 alkyl) 2 , (1-pyrrolinyl)(CH 2 ) 1-6 C(O), (1-piperidyl)(CH 2 ) 1-6 C(O), (4-morpholinyl)(CH 2 ) 1-4 C(O), C(O)OC 1-6 alkyl, C(O)O(CH 2 ) 2-4 OC 1-6 alkyl, C(O)O(CH 2 ) 2-4 N(C 1-6 alkyl) 2 , (1-pyrrolinyl)(CH 2 ) 2-4 OC(O), (1-piperidyl)(CH 2 ) 2-4 OC(O), (4-morpholinyl)(CH 2 ) 2-4 OC(O), (CH 2 ) 1-4 C(O)OC 1-6 alkyl, or Ar(CH 2 ) 1-4 ; R 10 represents H, C 1-6 alkyl, or F; R 11 and R 12 represent independently at each occurrence H, F, Cl, Br, I, CN, NO 2 , CF 3 , OH, NH 2 , C 1-4 alkyl, OC 1-4 alkyl, OCF 3 , OCF 2 CH 3 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , OC(O)C 1-4 alkyl, NHC(O)H, NHC(O)C 1-4 alkyl, N(C 1-4 alkyl)C(O)C 1-4 alkyl, C(O)OC 1-4 alkyl, C(O)NHC 1-4 alkyl, C(O)N(C 1-4 alkyl) 2 , COOH, C(O)C 1-4 alkyl, S(O)C 1-4 alkyl, SO 2 C 1-4 alkyl, SO 2 NHC 1-4 alkyl, or SO 2 N(C 1-4 alkyl) 2 ; A represents a 5-7 membered aromatic ring containing from 0 to 4 heteroatoms selected from N, O or S; or a polycyclic aromatic group consisting of two or three 5 to 7-membered fused rings; B represents a 5-7 membered aromatic ring containing from 0 to 4 heteroatoms selected from N, O or S; or a polycyclic aromatic group consisting of two or three 5 to 7-membered fused rings; Ar is phenyl; D represents O, S, NH, or methylene; m and n independently represent an integer from 0 to 4; z is 1, or 2; and t and u independently represent an integer from 1 to 4.