Patent ID: 8304413

Claim:
A compound of formula II wherein R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, cyano, sulfonamido, halo, alkenylenearyl, and heteroaryl; R 2 is selected from the group consisting of aryl; unsubstituted heteroaryl; heteroaryl substituted with one or more substituents selected from halo, unsubstituted alkyl, alkenyl, OCF 3 , NO 2 , CN, NC, OH, alkoxy, haloalkoxy, amino, CO 2 H, and CO 2 alkyl; haloalkylcarbonyl; cycloalkyl; hydroxylalkyl; sulfonamide; unsubstituted cycloheteroalkyl and cycloheteroarlkyl substituted with one to three substituents independently selected from alkyleneOH, C(O)NH 2 , NH 2 , aryl, haloalkyl, halo, and OH; or R 2 and R 1 together form an optionally substituted 5-membered nitrogen-containing heterocyclic ring; R 3 is selected from the group consisting of hydrogen, aryl, alkenylenearyl, heteroaryl, alkyl, alkenyl, haloalkyl, amino, and hydroxy; R 4 is selected from the group consisting of hydrogen, haloalkyl, alkoxy, alkenyl, and alkenylenearyl; X 1 , X 2 , X 3 , and X 4 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, hydroxy, amino, aryl, cycloalkyl, thioalkyl, alkoxy, haloalkyl, haloalkoxy, alkoxyalkyl, cyano, aldehydro, alkylcarbonyl, amido, haloalkylcarbonyl, sulfonyl, and sulfonamide, or X 2 and X 3 together form a 5- or 6-membered ring comprising —O(CH 2 ) n O—, wherein n is 1 or 2, wherein at least one of X 1 , X 2 , X 3 , and X 4 is not hydrogen; and X 5 is hydrogen, with the proviso that (a) at least one of X 1 , X 2 , X 3 , and X 4 is not selected from the group consisting of hydrogen, halo, alkoxy, and hydroxy or (b) at least one of R 1 , R 2 , R 3 , or R 4 is not selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, hydroxyalkyl, alkoxy, phenyl, substituted phenyl, halo, hydroxy, and alkoxyalkyl, or a pharmaceutically acceptable salt, or ester thereof.