Patent ID: 8063222

Claim:
A compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein: X 1 is a covalent bond, C═O or CR a R b , wherein R a and R b are each independently H or a C 1 -C 3 alkyl group; m is 0, 1, 2 or 3; n is 1 or 2; C═Z is C═O, CH 2 , C═NH, C═S, or is absent, provided that: i) when X 1 is a covalent bond then C═Z is other than CH 2 ; and ii) when C═Z is absent then X is a covalent bond; R 1 is: i) a substituted or unsubstituted aromatic or carbocyclic ring; or ii) when X is NR 5 , then for NR 5 (CH 2 ) m R 1 , R 5 and (CH 2 ) m R 1 taken together with the nitrogen atom to which they are bound, form a substituted or unsubstituted non-aromatic heterocyclic ring; R 2 is —H or a C 1 -C 3 alkyl group; R 3 is —H; R 4 is a substituted or unsubstituted group selected from an aromatic ring, a non-aromatic ring, or a bridged bicyclic ring, wherein the aromatic ring, the non-aromatic ring, or the bridged bicyclic ring is bound directly to the nitrogen atom or through a C 1 -C 4 alkyl group; or R 3 and R 4 , taken together with the nitrogen atom to which they are bound, is a substituted or unsubstituted nitrogen-containing non-aromatic heterocyclic ring; X is a covalent bond, 0, or NR 5 , wherein R 5 is —H or a C 1 -C 3 alkyl group; Ar in Formula (I) is selected from: wherein Ar is optionally substituted at any substitutable carbon or nitrogen atom with p independent occurrences of R 6 , wherein: p is 0, 1, 2, or 3; and each occurrence of R 6 is independently halogen, —CN, NO 2 , —R 7 , or —OR 7 , wherein each occurrence of R 7 is independently hydrogen or a substituted or unsubstituted C 1 -C 6 aliphatic group, provided that when R 4 is a non-aromatic ring, then the non-aromatic ring is substituted with a group other than —COOH, —SO 2 NH 2 , or —SO 3 H.