Patent ID: 7459550

Claim:
A process for the preparation of Cefditoren of formula (I) or its ester or pharmaceutically acceptable salts there of which comprising the steps of: i) converting the compound of formula (II) wherein R 1 represents carboxy protecting group to a compound of the formula (III) using triphenylphosphine and alkali iodide in the presence of aprotic solvent, water and base, ii) reacting the compound of formula (III) with 4-methyl-5-formyl-thiazole in the presence of aprotic solvent, water and base to produce a compound of formula (IV) wherein R 1 is as defined above, iii) deesterifying the carboxy protecting group of compound of the formula (IV) using an acid in the presence of solvent to yield compound of formula (V), iv) converting the compound of formula (V) to compound of formula (VI) wherein X represents a counter ion which forms a salt; in the presence of a base and solvent, v) converting the compound of formula (VI) into compound of formula (VII) by enzymatic hydrolysis, and vi) reacting compound of formula (VIII) with compound of formula (VII) wherein Y is selected from halogen, and 2-mercaptobenzothiazole (MBT), and in the presence of solvent and in presence or absence of base to produce compound of formula (I).