Patent ID: 7108844

Claim:
A method for treating a solid tumor comprising: a) locating a solid tumor in the body of a patient, b) surgically removing at least a portion of the solid tumor, and c) administering to the patient by direct injection into the remaining tumor or into the tissue surrounding said tumor, or by a combination of direct injection into the remaining tumor or the tissue surrounding said tumor and systemic administration, a pharmaceutical composition containing an oligonucleotide comprising at least one octameric motif AACGTTAT (SEQ ID NO: 51), wherein the CG in said octameric motif is non-methylated and wherein said oligonucleotide is stabilized by a modified backbone comprising a phosphorothioate, a phosphorodithioate, or a phosphodiester-phosphorothioate mixture, or is an oligonucleotide stabilized at a 3′ and/or 5′ end.