Patent ID: 7781583

Claim:
A method of producing a compound of formula Ic wherein X 1 is Cl; R 1 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydoxyalkyl, or C 3 -C 7 cycloalkyl; and R 3 is hydrogen, OH, —NH 2 , aryl, C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, or C 3 -C 7 -heterocyclyl; comprising the steps of (g) reacting a compound of formula Ib: with a compound of the formula wherein R a is selected from H, C 1 -C 3 alkyl and —C(O)—C 1 -C 3 alkyl, in the presence of diisopropylethylamine, a transition metal catalyst selected from tetrakis(triphenylphosphine)palladium, tris(dibenzylideneacetone)dipalladium, bis(dibenzylideneacetone) palladium(0), palladium acetate, palladium chloride, bis(benzonitrile)dichloropalladium and (Bis-(diphenylphosphinoferrocene) palladium dichloride dichloromethane complex and optionally a phosphine agent selected from 2,2′-bis (diphenylphosphino)-1,1′-binaphthalene, 1,3 bis(diphenylphosphino)propane, triphenylphosphine, triorthotolylphosphine and tri-t-butylphosphine, and in a suitable solvent selected from toluene and THF; to produce the compound of formula Ic.