Patent ID: 8388910

Claim:
A portable test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module comprising: an outer casing configured for hand-held portability, the outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences; electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer; a lab-on-a-chip (LOC) device with a supporting substrate for supporting CMOS circuitry, electrodes for receiving an electrical pulse to excite the ECL luminophores and an array of hybridization chambers containing the ECL probes for different target nucleic acid sequences wherein the CMOS circuitry has memory for storing the identity data relating to the ECL probes in each of the hybridization chambers such that the ECL probes detect one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes; and, a plurality of calibration sources each configured to provide a calibration emission, the calibration sources being distributed throughout the array of hybridization chambers such that each of the calibration sources are surrounded by a three-by-three square of the hybridization chambers.