Patent ID: 7893291

Claim:
A method of synthesizing an oxidized phospholipid having a formula: or pharmaceutically acceptable salts thereof, wherein: (i) A 1 and A 2 are each independently selected from the group consisting of CH 2 and C═O, at least one of A 1 and A 2 being CH 2 ; (ii) R 1 is selected from the group consisting of an alkyl chain having 1-27 carbon atoms and wherein X is an alkyl chain having 1-24 carbon atoms, Y is selected from the group consisting of: —OH, —H, alkyl, alkoxy, halogen, acetoxy and aromatic functional groups; and Z is selected from the group consisting of: whereas R 4 is an alkyl, (iii) R 2 is wherein X is an alkyl chain having 1-24 carbon atoms, Y is selected from the group consisting of: —OH, —H, alkyl, alkoxy, halogen, acetoxy and aromatic functional groups; and Z is selected from the group consisting of: whereas R 4 is an alkyl; and (iv) R 3 is selected from the group consisting of H, acyl, alkyl, phosphoryl choline, phosphoryl ethanolamine, phosphoryl serine, phosphoryl cardiolipin and phosphoryl inositol, the method comprising: (a) providing a phospholipid backbone including two fatty acid side chains and said R 3 , wherein at least one of said fatty acid side chains is a mono-unsaturated fatty acid having 2-15 carbon atoms at an sn-2 position of said backbone, and wherein at least one of said fatty acid side chains is attached to said backbone via an ether bond; and (b) oxidizing the unsaturated bond of said mono-unsaturated fatty acid to thereby generate the oxidized phospholipid.