Patent ID: 7550608

Claim:
A process for the preparation of docetaxel, the process comprising: (a) protecting the C(7) and the C(10) hydroxy groups of 10-deacetylbaccatin III (10-DAB) with a bridging silicon-based protecting group to form 10-DAB derivative (12); (b) treating 10-DAB derivative (12) with a β-lactam side chain precursor to form 10-DAB derivative (13); and (c) deprotecting 10-DAB derivative (13) to form docetaxel; wherein 10-DAB derivative (12) and 10-DAB derivative (13) correspond to Formulae (12) and (13), respectively: the bridging silicon-based protecting group corresponds to Formula (2): the β-lactam side chain precursor corresponds to Formula (3): L 1 and L 2 are amine, bromo, chloro, iodo, or sulfonate leaving groups; X 6 is a hydroxy protecting group; and Z is —CH 2 —CH 2 —, —O—Si(CH 3 )(CH 3 )—O—, or —O—.