Patent ID: 8293760

Claim:
A compound of Formula 1: or a pharmaceutically acceptable salt thereof; wherein; R 1 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, hydroxyl, aralkyl, heteroaryl, heteroaralkyl, haloalkyl, alkoxyl, —SR 20 , —OR 20 , —N(R 20 )(R 20 ), —C(O)R 20 , —CO 2 R 20 , —OC(O)R 20 , —C(O)N(R 20 )(R 20 ), —N(R 20 )C(O)R 20 , —N(R 20 )C(O)N(R 20 )(R 20 ), —S(O)R 20 , —S(O) 2 R 20 , —S(O) 2 N(R 20 )(R 20 ), —N(R 20 )S(O) 2 R 20 , —[(W)—C(O)] p R 20 , —[(W)—C(O)O] p R 20 , —[(W)—OC(O)] p R 20 , —[(W)—SO 2 ] p R 20 , —[(W)—N(R 20 )SO 2 ] p R 20 , —[(W)—C(O)N(R 20 )] p R 20 , —[(W)—O] p R 20 , —[(W)—N(R 20 )] p R 20 , or —[(W)—S] p R 20 ; each of R 2 , R 7 and R 13 is independently H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, alkoxyl, aryloxy, acyloxy, halide, hydroxyl, amino, alkylamino, arylamino, acylamino, aralkylamino, alkylseleno, aralkylseleno, arylseleno, alkylthio, aralkylthio, arylthio, heteroaryl, or heteroaralkyl; R 3 is H; or R 2 and R 3 taken together form a bond; each of R 4 and R 5 independently is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, nitrile, aralkyl, alkoxyl, aryloxy, acyloxy, halide, sulfhydryl, alkylthio, arylthio, aralkylthio, hydroxyl, amino, alkylamino, arylamino, acylamino, aralkylamino, heteroaryl, or heteroaralkyl; or R 4 and R 5 taken together form ═O, ═S, ═N(R 20 ), ═N—OR 20 or ═N(N(R 20 ) 2 ); R 6 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, or aralkyl; each of R 8 and R 12 independently is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, or aralkyl; or R 7 and R 8 taken together form a bond; or R 12 and R 13 taken together form a bond each of R 9 and R 16 independently is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, nitrile, aralkyl, heteroaryl, or heteroaralkyl; or R 9 and R 10 taken together form ═O, ═N(R 20 ), ═N—OR 20 , or ═S; R 11 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, —C(O)R 20 , —C(S)R 20 , —CO 2 R 20 , —SO 2 R 20 , —C(O)N(R 20 )(R 20 ), or —C(S)N(R 20 )(R 20 ); or has the formula) —[C(R 20 ) 2 ] q —R 21 ; R 20 independently for each occurrence is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, or —[C(R) 2 ] q —R 21 , where each R is independently H or C1-C6 alkyl; or any two occurrences of R 20 can be taken together to form a 4-8 membered optionally substituted ring which contains 0-3 heteroatoms selected from N, O, S, and P; R 21 independently for each occurrence is H, cycloalkyl, aryl, heteroaryl, heterocyclyl; alkoxyl, aryloxy, acyloxy, halide, sulfhydryl, alkylthio, arylthio, aralkylthio, hydroxyl, amino, acylamino, amido, or a carbonyl-containing group; R 22 independently for each occurrence is H, halide, ester, amide, or nitrile; p is 0, 1, 2, 3, 4, 5, or 6; q is 0, 1, 2, 3, 4, 5, or 6; W is a diradical; X is a bond or —C(R 22 ) 2 —; and each alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, whether alone or part of another group, is optionally substituted.