Patent ID: 8735424

Claim:
A compound of Formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein, X 2 , and X 4 are N, and X 1 , X 3 , X 5 , and X 6 are CR 2 ; or X 4 is N and X 1 , X 2 , X 3 , X 5 , and X 6 are CR 2 ; Y is selected from a group consisting of piperidinyl, piperazinyl, cyclohexyl, pyrimidyl, and pyrazinyl, wherein each member of the group is substituted with up to four substituents; Z 1 , Z 2 , and Z 3 are each CR 12 ; R 1 is selected from the group consisting of halo, and substituted or unsubstituted alkyl, alkenyl, alkynyl, alkoxy, amino, cycloalkyl, hetero cycloalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, heterocyclyloxy, cycloalkyloxy, acyl, acylamino and acyloxy, and partially saturated cycloalkyl; and R 2 and R 12 independently at each occurrence are selected from the group consisting of hydrogen, halo, hydroxyl, and substituted or unsubstituted alkyl, alkenyl, alkynyl, alkoxy, amino, cycloalkyl, hetero cycloalkyl, aminocarbonyloxy, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, (carboxyl ester)amino, (carboxyl ester)oxy, sulfonyl, sulfonyloxy, thioacyl, thiol, alkylthio, aryl, heteroaryl, aryloxy, heteroaryloxy, heterocyclyloxy, cycloalkyloxy, acyl, acylamino and acyloxy, and partially saturated cycloalkyl.