Patent ID: 7705006

Claim:
A cyclopenta[g]quinazoline of the formula (I): wherein: A is a group OR 0 or NR 0 R 1 wherein R 0 and R 1 are each independently hydrogen or C 1-4 alkyl; p is an integer in the range 1 to 4; R 2 is ethyl, propyl, prop-2-enyl, prop-2-ynyl, 2-hydroxyethyl, 2-fluoroethyl, 2-bromoethyl or 2-cyanoethyl; Ar 1 is 1,4-phenylene which may optionally bear one or two substituents selected from the group consisting of chloro, fluoro, thiophene-2,5-diyl, thiazole-2,5-diyl or pyridine-2,5-diyl; and R 3 is a group of the formula: -A 5 -CON(R)CH(Y 4 )Y 5 in which A 5 is a C 1-6 alkylene group; R is hydrogen, C 1-4 alkyl, C 3-4 alkenyl or C 3-4 alkynyl; Y 4 is carboxy, tetrazol-5-yl, N-(C 1-4 alkylsulfonyl)carbamoyl, N-(phenylsulfonyl)carbamoyl which may optionally bear one or two substituents on the phenyl ring selected from the group consisting of halogeno, nitro, C 1-4 alkyl and C 1-4 alkoxy, tetrazol-5-ylthio, tetrazol-5-ylsulfinyl or tetrazol-5-ylsulfonyl; and Y 5 is the residue of a naturally occurring amino acid NH 2 CH(CO 2 H)Y 5 ; the compound (I) optionally being in the form of a pharmaceutically acceptable salt or ester.