Patent ID: 8637662

Claim:
A compound represented by formula (I): wherein R1 is (CH 2 ) n —Z—(CH 2 ) n′ —R4 wherein n and n′ are each independently 0, 1, or 2; Z is a single bond or is selected from the group consisting of S, O, CO, and NR3, wherein R3 is selected from the group consisting of H, straight or branched (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 8 )cycloalkyl, aryl, aryl(C 1 -C 6 )alkyl and heteroaryl, each of which are optionally substituted by CN; R4 is selected from the group consisting of: H, halogen, OH, SH, CN, NH 2 ; aryl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkylcarbonyl, (C 1 -C 6 )alkylcarboxyl, O(C 1 -C 6 )alkylcarboxyl, (C 1 -C 6 )alkylamide, and (C 1 -C 6 )alkoxy, each of which are optionally substituted by one or more oxo groups; (C 1 -C 6 )alkyl which may be optionally substituted by one or more substituents selected from the group consisting of a halogen atom, CN, OH, NH 2 , NO 2 , CF 3 and SH; (C 2 -C 6 )alkynyl; a mono-, bi- or tricyclic saturated or partially saturated or unsaturated ring, optionally substituted by one or more halogen atoms or oxo groups; R2 is selected from the group consisting of H; (CH 2 ) m R5, wherein R5 is heteroaryl optionally substituted with a substituent selected from the group consisting of oxo, OH, halogen, CN, NH 2 , NO 2 , aryl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylcarboxyl, (C 1 -C 6 )alkylamide, aryl(C 1 -C 6 )alkoxy, and (C 1 -C 6 )alkyl, each of which may be optionally substituted by one or more halogen atoms or COOH; (CH 2 ) p NR6R7; (CH 2 ) p NR6COR7; (CH 2 ) p NR6SO 2 R7; (CH 2 ) m CONR6R7; (CH 2 ) m SO 2 NR6R7; (CH 2 ) m COR7; (CH 2 ) p OR7; (CH 2 ) m SO q R7; wherein R6 and R7 are independently H or are selected from the group consisting of straight or branched (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, aryl(C 1 -C 6 )alkyl and a saturated, partially saturated or unsaturated, optionally fused ring, each of which may be optionally substituted with one or more substituents selected from the group consisting of halogen, CN, oxo, NH 2 , NO 2 and (C 1 -C 6 )alkyl; and (CH 2 ) p R8 wherein R8 is selected from the group consisting of halogen, oxo, CN, OH, NH 2 , NO 2 ; (C 3 -C 8 )cycloalkyl, and a saturated, partially saturated or unsaturated optionally fused ring, which may be optionally substituted by one or more substituents selected from the group consisting of halogen, CO, CN, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )carboxyalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy and (C 1 -C 6 )alkylsulfonyl; or R8 is aryl which is substituted by one or more substituents selected from the group consisting of halogen, CO, CN, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )carboxyalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy and (C 1 -C 6 )alkylsulfonyl; wherein m and p are, each independently, 0 or an integer from 1 to 6, and q is 0, 1 or 2; and X and Y are each independently a halogen atom, or a pharmaceutically acceptable salt thereof.