Patent ID: 7189824

Claim:
A monoclonal antibody which recognizes an antigen having a molecular weight of 80 kD on the surface of tumor vessel endothelial cells, and having a binding affinity for tumor vessel endothelial cells equivalent to or greater than the binding affinity for normal vessel endothelial cells as measured by ELISA, wherein: the antigen having the molecular weight of 80 kD is present on the surface of endothelial cells in liver tissue and spleen tissue, and the molecular weight of the antigen is determined by non-denaturing SDS-PAGE, and the monoclonal antibody is selected from the group consisting of: (a) an antibody produced by a hybridoma bearing the accession number FERM BP-5787; (b) a chimeric antibody comprising the variable regions of an antibody produced by said hybridoma; and (c) a reshaped human antibody comprising the complementarity determining regions of an antibody produced by said hybridoma.