Patent ID: 7138525

Claim:
A compound of the formula (III-1): wherein R 1p is lower alkyl, cyclo-lower alkyl, cyclo(lower alkyl)-lower alkyl or lower alkoxy, any of which is optionally substituted by a substituent selected from the group consisting of halogen, di-lower alkylamino, lower alkoxy, formyl, lower alkoxycarbonyl, di-lower alkylcarbamoyl, lower alkylamino; lower alkylamino protected by an imino-protecting group selected from the group consisting of aralkyl, lower alkanoyl, arylalkanoyl, lower alkoxycarbonyl, aralkyloxycarbonyl and lower alkylsilyl; lower alkanoylamino; lower alkanoylamino protected by an imino-protecting group selected from the group consisting of aralkyl, lower alkanoyl, benzoyl, arylalkanoyl, lower alkoxycarbonyl, aralkyloxycarbonyl and lower alkylsilyl; hydroxy; hydroxy protected by an hydroxy-protecting group selected from the group consisting of lower alkylsilyl, lower alkoxymethyl, tetrahydropyranyl, trimethylsilylethoxymethyl, aralkyl and acyl; lower alkylcarbamoyl; and lower alkylcarbamoyl protected by an imino-protecting group selected from the group consisting of aralkyl, lower alkanoyl, benzoyl, arylalkanoyl, lower alkoxycarbonyl, aralkyloxycarbonyl and lower alkylsilyl; R 3p is hydrogen, cyano, halogen; hydroxy; or hydroxy protected by an hydroxy-protecting group selected from the group consisting of lower alkylsilyl, lower alkoxymethyl, tetrahydropyranyl, trimethylsilylethoxymethyl, aralkyl and acyl; or lower alkyl, lower alkoxy or lower alkylthio, the last three groups being optionally substituted by a substituent selected from the group consisting of halogen, di-lower alkylamino, lower alkoxy, formyl, lower alkoxycarbonyl, di-lower alkylcarbamoyl, lower alkylamino; lower alkylamino protected by an imino-protecting group selected from the group consisting of aralkyl, lower alkanoyl, benzoyl, arylalkanoyl, lower alkoxycarbonyl, aralkyloxycarbonyl and lower alkylsilyl; lower alkanoylamino; lower alkanoylamino protected by an imino-protecting group selected from the group consisting of aralkyl, lower alkanoyl, benzoyl, arylalkanoyl, lower alkoxycarbonyl, aralkyloxycarbonyl and lower alkylsilyl; hydroxy; hydroxy protected by an hydroxy-protecting group selected from the group consisting of lower alkylsilyl, lower alkoxymethyl, tetrahydropyranyl, trimethylsilylethoxymethyl, aralkyl and acyl; lower alkylcarbamoyl; and lower alkylcarbamoyl protected by an imino-protecting group selected from the group consisting of aralkyl, lower alkanoyl, benzoyl, arylalkanoyl, lower alkoxycarbonyl, aralkyloxycarbonyl and lower alkylsilyl; provided that the compound of the formula (III-1) wherein (i) R 1p is methyl and R 3p is hydrogen, bromo, ethyl or methoxy, (ii) R 1p is cyclohexyl and R 3p is hydrogen and (iii) R 1p is n-propyl and R 3p is hydrogen, are excluded.