Patent ID: 7943633

Claim:
A method for protecting against malaria infection in a subject or treating a subject suffering from malaria comprising: administering to said subject an effective amount of a compound of formula (I): wherein R 1 is H or OC i H 2i+1 with i between 0 and 6; R 2 is H or OC j H 2j+1 with j between 0 and 6; R 3 is H or OC k H 2k+1 with k between 0 and 6; R 4 is H or OH; R 5 is OH or with OC m H 2m+1 between 1 and 6 or an acetoxy group or an oxo group; R 6 is OH or OC n H 2n+1 with n between 1 and 6 or an acetoxy group or an oxo group; R 7 is OC p H 2p+1 with p between 0 and 6; R 8 and R 9 may be similar or different and represent H or OC q H 2q+1 with q between 0 and 6, or Hal where Hal is Cl, Br, F or I, or form together a covalent bond whereby the bond is a double bond or an ether bond (epoxy group); R 10 is H or C r H 2r+1 with r between 1 and 12 or an unsaturated alkyl group or a cycloalkyl group (tri- to hexa-) unsaturated or not, with or without heteroatoms; or an aromatic or a polycyclic aromatic group with or without heteroatoms; or C s H 2s -A with s between 1 and 12 and whereby A is a saturated or (tri- to hexa-) unsaturated cycloalkyl group, with or without heteroatoms or an aromatic or a polycyclic aromatic group with or without heteroatoms or A is C 6 H 5-t -(Hal) t with t between 1 to 5 or C 6 H 5-u —(O—C v H 2v+1 ) u with u between 1 to 5 and v between 0 and 6; or R 10 represents two substituents similar or different rendering the nitrogen atom quaternized, or an oxygen atom (nitrone group) and in which case the bond between the nitrogen atom and C 9 is a double bond; or R 10 represents CH 2 CH 2 [OCH 2 CH 2 ] w OCH 2 CH 2 —B with w between 0 and 10 and where B is OH, O-D or NH-D where D is a C 1 -C 12 alkyl group bearing an electrophilic function such as an isothiocyanate; R 11 is H or OH or OC x H 2x+1 with x between 1 and 6 or Hal where Hal is Cl, Br, F or I; or an acetoxy group or a sulfonate ester group or an oxo group; or R 10 and R 11 may represent an isoalkylidene group; or a compound of formula (II): wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 2 , R 8 and R 9 are defined as above; R 4 is H or OH or OC l H 2l+1 with 1 between 2 and 6; R 10 is C y H 2y with y between 1 and 12 or CH 2 CH 2 [OCH 2 CH 2 ] z CH 2 CH 2 with z between 0 and 10; and R 11 is H or OH or OC x H 2x+1 with x between 1 and 6 or Hal where Hal is Cl, Br, F or I; or an acetoxy group or a sulfonate ester group or an oxo group; all stereoisomers and optical isomers of said formula I or formula II or pharmaceutically acceptable salts thereof.