Patent ID: 8486639

Claim:
Nanoassembled complexes comprising a nucleus obtained by means of high affinity interaction between one or more avidin units and one or more nucleic acid molecules, wherein said nucleus is stabilized by a biotinylated surface protecting agent, represented by the general formula (I) NB n Av y (B-X a -PA b ) z (I) wherein: NB are the single nucleobases of a single or double stranded nucleic acid; Av is an avidin unit; B-X a -PA b is the biotinylated surface protecting agent in which PA is a polymer having at least one or two functionalizable residues of which one binds, by a covalent bond either directly or through a spacer X, to a biotin residue B by means of carboxyl functional group of said residue B selected from the group consisting of polyethylene oxide or polyethylene glycol (PEO or PEG) optionally substituted, a polyoxyethylene and polyoxypropylene copolymer (PEO-PPO); n is a number greater than 16; y is an integer equal to or greater than 1 (≧1) and is related to n as having a value in the range from (0.0001)·n to (0.0454)·n with the proviso that if a value in the range (0.0001-0.0454)·n is less than 1 (<1), then y is equal to 1 (=1); z is an integer equal to or greater than 1 (≧1) and is related to y as having a value in the range from (0.02)·y to (4)·y with the proviso that if a value in the range (0.02-4)·y is less than 1 (<1), then z is equal to 1 (=1); a is a number from 0 to 50; b is a number from 1 to 128.