Patent ID: 7034047

Claim:
A pharmaceutical composition for glycine transporter inhibitor which comprises a triazole derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as the effective ingredient: (in the formula, the symbols represent the following meanings; Ring A: (3) a 5-membered hetero ring which may be substituted and contain one or two nitrogen atoms as the hetero atoms composing the ring and may contain one oxygen atom or sulfur atom as a hetero atom other than the nitrogen atoms and may be condensed with benzene ring or Ring B or D may be the same or different and each represents aromatic carbon ring which may be substituted, an aliphatic carbon atom which may be substituted, or a hetero ring which may be substituted. R: H, halogeno-lower alkyl, aryl which may be substituted, hetero ring which may be substituted, cycloalkyl which may be substituted, or -[Alk1]m-X-[Alk2]n-Y—R 1 wherein R 1 : H, OH, cyano, aryl which may be substituted, hetero ring which may be substituted, cycloalkyl which may be substituted, or lower alkoxyl; X: bond, oxygen atom, S(O)q, or —N(R 2 )—; Y: bond, —C(O)—, —C(O)—N(R 3 )—, -Z 1 -Alk3-, or —N(R 3 )-Alk3-C(O)—, with the proviso that R 1 represent other than OH and lower alkoxy, when Y is bond; Alk1 or Alk2 may be the same or different and each represents lower alkylene, lower alkenylene or lower alkynylene; and m or n may be the same or different and each represents 0 or 1 or m+n=1, provided that X represents bond; Z 1 : S(O)q, —N(R 3 )—, —C(O)— or —C(O)—N(R 3 )—; Alk3: lower alkylene; R 2 or R 3 : the same or different from each other and each represents H or lower alkyl; q may be 0, 1, or 2.