Patent ID: 7022695

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein R 1a is a member selected from the group consisting of H, halogen, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, (C 1-6 alkyl) 0-2 amino and C 1-6 alkylcarbonyl; R 1b and R 1c are each members independently selected from the group consisting of H and C 1-6 alkyl, or optionally, R 1b and R 1c are combined with the nitrogen atom to which each is attached to form a 5-, 6- or 7-membered monocyclic ring having from 0 to 1 additional heteroatom ring members or an 8-, 9-, 10- or 11-membered bicyclic ring having 0–2 additional heteroatom ring members, said heteroatom ring members selected from O, N, S, S(O) and S(O) 2 , said ring being further substituted with from zero to two substituents independently selected from the group consisting of C 1-6 alkyl, (C 1-6 alkyl) 0-2 amino, oxo and an amine protecting group; R 1d and R 1e are each members independently selected from the group consisting of H, halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, (C 1-6 alkyl) 0-2 amino and aminoC 1-6 alkyl; or R 1d and R 1e are combined to form a fused 5–6 membered ring having 0–2 ring heteroatoms selected from N, O and S; X is O, S or together with the carbon atom to which it is attached is CH 2 ; Y is CH or N; and Z is a group having the formula: wherein R 2a , R 2b and R 2c are each members independently selected from the group consisting of H, hydroxy, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy and (C 1-6 alkyl) 0-2 amino; or optionally, any two of R 2a , R 2b and R 2c are taken together with their intervening atom(s) to form a 3-, 4-, 5-, 6- or 7-membered ring having from 0 to 1 additional heteroatom ring members selected from O, N, S, S(O) and S(O) 2 , said ring being further substituted with from zero to two substituents independently selected from the group consisting of C 1-6 alkyl, hydroxy, C 1-6 alkoxy, CO 2 H, oxo and (C 1-6 alkyl) 0-2 amino.