Patent ID: 7932376

Claim:
A compound of Formula I, or its tautomer, or salt thereof: wherein: R 1 and R 2 are each independently selected from the group consisting of: hydrogen, C 1-8 alkyl, C 1-8 alkenyl, C 1-8 alkynyl, C 3-7 cycloalkyl, C 4-7 cycloalkenyl, aralkyl, aryl, heteroaryl, and saturated or unsaturated C 3-6 heterocycle; where all rings or chains optionally can bear one or more desired substituents; or R 1 and R 2 are taken together to form a ring of 3 to 7 members, with or without substitution, and with or without heteroatoms in place of ring carbon atoms; R 3 and R 4 are independently hydrogen, alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl. R 5 is —NH—CO—NHR 8 , where R 8 is alkyl, cycloalkyl, alkylcycloalkyl, or aryl; R 6 is absent; D is O or CH 2 ; V, Z, and Y are independently CH 2 with H optionally substituted by alkyl groups or halogens, C═O, O, S, SO, SO 2 , or NH with H optionally substituted by an alkyl group or an acyl group; and when V and Z or Z and Y are both carbon, the linkage between the atom pair can be a saturated or unsaturated bond; or V, Z, and Y are independently absent; X═H, —S(O)R′, —S(O 2 )R′, —SO 3 H, —S(O 2 )NR′R″, —NR′R″, or —COOR′, where R′ and R″ are independently H, a physiologically-relevant cation forming a carboxylate salt, alkyl, aryl, or aralkyl; or X is a group as provided in Formula II: wherein: X 6 is the attachment point to the moiety defined by V—Z—Y; the ring defined by X 1 -X 6 is taken to mean a ring with or without unsaturation; and X 1 -X 6 are independently C, N, O, or S; and if any of X 1 -X 5 is C, the carbon atom is optionally substituted with halogen, alkyl, alkoxy, or aminoalkyl; and if any of X 1 -X 5 is N in an saturated ring, the nitrogen atom optionally bears substituents such as alkyl or acyl; or any of X 1 -X 5 can be absent, with the proviso that at least two of X 1 -X 5 are present, such that the ring described by X 1 -X 6 consists of at least three atoms; with the provisos that no two adjacent atoms X 1 -X 6 are O—O or S—S and that the ring shown in Formula II contains no more than four heteroatoms, and that the shown pendant —CO 2 R 7 unit in Formula II is a substituent on the ring described in Formula II, and that the ring of Formula II contains no halogen-group, hydroxy-group, sulfhydryl-group, or amino-group attached to an sp 3 -hybridized-carbon atom that is bonded directly to a heteroatom selected from the group consisting of O, S, and N, as such types of compounds are unstable in many cases; p=0, 1, or 2; r=0 or 1; R 7 is H, a physiologically-relevant cation forming a carboxylate salt, alkyl, aryl, or aralkyl; and M is H, halogen, alkyl, aminoalkyl, alkoxy, or acyl.