Patent ID: 7001759

Claim:
A composition comprising: a) a polynucleotide function enhancer; and b) A DNA molecule that comprises a DNA sequence that encodes an antigen from an intracellular pathogen; wherein i) said polynucleotide function enhancer is a compound having one of the following formulas: Ar—R 1 —O—R 2 —R 3 or Ar—N—R 1 —R 2 —R 3 or R 4 —N—R 5 —R 6 or R 4 —O—R 1 —R 7 wherein: Ar is benzene, p-aminobenzene, m-aminobenzene, o-aminobenzene, substituted benzene, substituted p-aminobenzene, substituted m-aminobenzene, substituted o-aminobenzene, wherein the amino group in the aminobenzene compounds can be amino, C 1 –C 5 alkylamine, C 1 –C 5 , C 1 ‥C 5 dialkylamine and substitutions in substituted compounds are halogen, C 1 –C 5 alkyl and C 1 –C 5 alkoxy; R 1 is C═O; R 2 is C 1 –C 10 alkyl including branched alkyls; R 3 is hydrogen, amine, C 1 ‥C 5 alkylamine, C 1 –C 5 , C 1 –C 5 dialkylamine; R 2 +R 3 can form a cyclic alkyl, a C 1 –C 10 alkyl substituted cyclic alkyl, a cyclic aliphatic amine, a C 1 –C 10 alkyl substituted cyclic aliphatic amine, a heterocycle, a C 1 –C 10 alkyl substituted heterocycle including a C 1 –C 10 alkyl N-substituted heterocycle; R 4 is Ar, R 2 or C 1 –C 5 alkoxy, a cyclic alkyl, a C 1 –C 10 alkyl substituted cyclic alkyl, a cyclic aliphatic amine, a C 1 –C 10 alkyl substituted cyclic aliphatic amine, a heterocycle, a C 1 –C 10 alkyl substituted heterocycle and a C 1 –C 10 alkoxy substituted heterocycle including a C 1 –C 10 alkyl N-substituted heterocycle; R 5 is C═NH; R 6 is Ar, R 2 or C 1 –C 5 alkoxy, a cyclic alkyl, a C 1 –C 10 allyl substituted cyclic alkyl, a cyclic aliphatic amine, a C 1 –C 10 alkyl substituted cyclic aliphatic amine, a heterocycle, a C 1 –C 10 alkyl substituted heterocycle and a C 1 –C 10 alkoxy substituted heterocycle including a C 1 –C 10 alkyl N-substituted heterocycle; and, R 7 is Ar, R 2 or C 1 –C 5 alkoxy, a cyclic alkyl, a C 1 –C 10 alkyl substituted cyclic alkyl, a cyclic aliphatic amine, a C 1 –C 10 alkyl substituted cyclic aliphatic amine, a heterocycle, a C 1 –C 10 alkyl substituted heterocycle and a C 1 –C 10 alkoxy substituted heterocycle including a C 1 –C 10 alkyl N-substituted heterocycle; and, ii) said DNA sequence operatively linked to regulatory sequences which control the expression of said DNA sequence.