Patent ID: 7788041

Claim:
A computer readable storage medium having stored thereon computer-implemented instructions causing a processor to perform the steps of: (a) providing a data structure relating a plurality of Homo sapiens ( H. sapiens ) reactants to a plurality of H. sapiens reactions, wherein each of the H. sapiens reactions comprises one or more reactants identified as a substrate of the reaction, one or more reactants identified as a product of the reaction, and a stoichiometric coefficient relating the substrate and the product, wherein at least one of the H. sapiens reactions is annotated to indicate an associated gene in Table 4; (b) providing a gene database comprising information characterizing the associated gene; (c) providing a constraint set for the plurality of H. sapiens reactions; (d) determining at least one flux distribution that minimizes or maximizes an objective function when the constraint set is applied to the data structure, wherein the at least one flux distribution is predictive of a H. sapiens physiological function, wherein the data structure comprises Tables 1, 4, 5, 7 and 8; and (e) providing information resulting from steps (a) to (d) to a user.