Patent ID: 8329702

Claim:
A method for treating or lessening the severity of a disease, disorder, or condition which is implicated in the activation or hyperactivity of voltage-gated sodium channels in a patient, wherein said disease, disorder, or condition is selected from acute, chronic, neuropathic, or inflammatory pain, arthritis pain, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or epilepsy conditions, visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain, said method comprising the step of administering to said patient an effective amount of a composition comprising a compound of formula I and a pharmaceutically acceptable adjuvant or carrier wherein said compound of formula I comprises: or a pharmaceutically acceptable salt thereof, wherein: is a single or double bond; X 1 is —S—; X 2 is ═CR 3 —; X 3 is a lone pair of electrons; W is halo or OR′; R 1 and R 2 , taken together with the nitrogen atom, form a piperidinyl ring (cc) or a piperazinyl ring (dd): wherein z is 0-5; y is 0; R 3 is hydrogen; R 4 is Q-R X ; wherein Q is a bond or is a C 1 -C 6 alkylidene chain and R X is selected from —NR′COR′, —NR′CO 2 R′, —COR′, —CO 2 R′, or —SO 2 R′; R 5 is halogen; and each occurrence of R′ is independently hydrogen or an optionally substituted C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur.