Patent ID: 8263362

Claim:
A method for producing an isoprenoid compound, comprising: a) culturing a host cell under conditions suitable for expressing a first recombinant protein comprising an isoprenoid synthase and a second recombinant protein comprising a CYP71, CYP73, CYP82 or a CYP92 family cytochrome P450 polypeptide and under conditions for producing an isoprenoid compound, wherein: a CYP71, CYP73, CYP82, and CYP92 family cytochrome P450 polypeptide is encoded by nucleic acid that can be amplified with degenerate primers based on one of SEQ ID Nos. 26-29; the CYP71, CYP73, CYP82, and CYP92 family cytochrome P450 polypeptide has hydroxylase activity; and the first and second recombinant protein together catalyze the formation of an isoprenoid compound not normally produced by said host cell, wherein the cytochrome P450 polypeptide is selected from among polypeptides comprising at least 80% identity to polypeptides having an amino acid sequence set forth in SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9 and SEQ ID NO:11; and b) recovering the isoprenoid compound.