Patent ID: 7744916

Claim:
A vaginal device for delivering an anti-migraine or anti-nausea drug to a female subject, said device comprising the vaginal device; the anti-migraine or anti-nausea drug formulated as a mucoadhesive composition; and a fluid impermeable coating comprising said composition; wherein said vaginal device is a tampon, foam, ring, pessary, sponge, cylinder, tablet, capsule, pad, suppository, pellet or tube; wherein said anti-migraine drug is selected from the group of compounds consisting of ergotamine, dihydroergotamine, ergostine, butalbital, phenobarbital, acetaminophen, diclofenac sodium, ketoprofen, ketorolac, ibuprofen, piroxicam, naproxen, acetylsalicylic acid, flurbiprofen, tolfenamic acid, butorphanol, meperidine, methadone, sumatriptan, naratriptan, razatriptan, zolmitriptan, almotriptan, eletriptan, dexamethasone, hydrocortisone, isometheptene, chlorpromazine, diazepam, droperidol, valproic acid, gabapentin, topiramate and divalproex sodium, each alone or in combination, or in combination with the anti-nausea drug, and wherein said anti-nausea drug is selected from the group consisting of metoclopramide, prochlorperazine, domperidone, ondansetron, tropisetron, dolasetron, nabilone, dronabinol, levonantradol, aprepitant, cyclizine, promethazine, each alone or in combination or in combination with the anti-migraine drug; wherein said fluid impermeable coating is a degradable or non-degradable water soluble or non-soluble polymer selected from the group consisting of wax, plastic polymeric film, coated gauze, synthetic polymer, dextran, cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, polyethylene glycol, polyethylene, polyethylene oxide, alginate, chitosan, copolymer of ethylene oxide and propylene oxide, polyethylene oxide-co-propylene oxide, polyacrylic acid, collagen, albumin, gelatin, polylactide, polyglycolide, polyethylene terephthalate, polybutyric acid, polyvaleric acid, polylactide-co-caprolactone, polyanhydride, polyorthoester, polyamide, polypropylene, polystyrene, polyvinyl chloride, polymethacrylic acid and a derivative thereof, alone, or in combination, wherein said coating is attached to said device as a film, foil, sheet, beads or xerogel and is either incorporated into said device, attached to said device or inserted into said device.