Patent ID: 8278316

Claim:
A compound having the following Formula I, or pharmaceutically acceptable salt thereof: wherein, A 1 and A 2 are independently C or N; E is C or N; Q 1 , Q 2 , and Q 3 are independently C or N provided that at least one of Q 1 , Q 2 , and Q 3 is N but not more than one of Q 1 , Q 2 , and Q 3 is N; D 1 is a bond, —CR 8 R 9 X—, —XCR 8 R 9 —, —CHR 8 CHR 9 —, —CR 10 ═CR 10′ —, —C≡C—, or 1,2-cyclopropyl; X is O, S or NR 11 ; R 1 , R 2 , and R 3 are independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 5 cycloalkyl, —CF 3 , —OCF 3 , —OR 12 , substituted or unsubstituted phenyl, substituted or unsubstituted cycloalkoxy, and —SR 12 ; G is O, S or —NR 15 ; D 2 is substituted or unsubstituted C 2 to C 4 alkyl, substituted or unsubstituted substituted or unsubstituted C 3 to C 5 cycloalkyl, substituted or unsubstituted C 3 to C 5 cycloalkoxy, substituted or unsubstituted C 2 to C 3 alkyl-C 3 to C 5 cycloalkyl, substituted or unsubstituted C 1 to C 3 alkyl-substituted or unsubstituted C 3 to C 5 cycloalkoxy or when G is —NR 15 , G and D 2 together may optionally form an azetidine, pyrrolidine or piperidine ring; Z 1 and Z 2 are independently hydrogen, substituted or unsubstituted C 1 to C 3 alkyl, substituted or unsubstituted C 3 to C 5 cycloalkyl, —OCH 3 , substituted or unsubstituted C 3 to C 5 cycloalkoxy, halo, —CF 3 , —OCONR 14 R 14′ , —CN, —CONR 14 R 14′ , —SOR 12 , —SO 2 R 12 , —NR 14 COR 14′ , —NR 14 CO 2 R 14′ , —CO 2 R 12 , NR 14 SO 2 R 12 or —COR 12 ; R 5 , R 6 , and R 7 are independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 5 cycloalkyl, substituted or unsubstituted C 3 to C 5 cycloalkoxy, —CF 3 , —SR 12 , —OCH 3 , —OCH 2 CH 3 , —CN, —CONR 14 R 14′ , SOR 12 , SO 2 R 12 , NR 14 COR 14′ , NR 14 CO 2 R 12 . CO 2 R 12 , NR 14 SO 2 R 12 and —COR 12 ; R 8 , R 9 , R 10 , R 10 ′, R 11 are independently hydrogen or —CH 3 ; R 12 is substituted or unsubstituted C 1 to C 4 alkyl or substituted or unsubstituted C 3 to C 5 cycloalkyl; R 14 and R 14′ are independently H, substituted or unsubstituted C 1 to C 3 alkyl, substituted or unsubstituted C 3 to C 5 cycloalkyl or R 14 and R 14′ together with the N to which they are attached form a ring having 4 to 7 atoms; and R 15 is hydrogen or substituted or unsubstituted C 1 to C 4 alkyl.