Patent ID: 7947821

Claim:
An isolated polynucleotide encoding recombinant human bone morphogenetic protein-2 (rhBMP-2), wherein the polynucleotide encodes the mature polypeptide of rhBMP-2 as set forth in SEQ ID NO: 2, and the polynucleotide has the following properties: in SEQ ID NO: 2, the codon of the 9 th amino acid is cgc; in SEQ ID NO: 2, the codon of the 23 th amino acid is ttt; in SEQ ID NO: 2, the codon of the 34 th amino acid is gcg; in SEQ ID NO: 2, the codon of the 86 th amino acid is aaa; and in SEQ ID NO: 2, the codon of the 110 th amino acid is ggc.