Patent ID: 7108845

Claim:
A method of synthesis of a radiolabelled platinum chemotherapeutic agent comprising the steps of: (a) thermally decomposing a hydrohalide salt of platinum(II) or a hydrohalide salt of platinum(IV) to give a platinum(II) halide or a platinum(IV) halide; (b) converting the platinum(II) halide to a radiolabelled platinum(II) halide, or converting the platinum(IV) halide to a radiolabelled platinum(IV) halide wherein the radiolabel is a radioisotope of Pt; and (c) synthesising the radiolabelled platinum chemotherapeutic agent from the radiolabelled platinum halide; wherein said radiolabelled platinum chemotherapeutic agent is selected from compounds of the general formulae (I) and (II): where each A is independently selected from halo, hydroxy, alkoxy and carboxylate or in which two A ligands together form a bi-dentate ligand; each B, which may be the same or different is selected from halo, hydroxy, carboxylate, carbamate and carbonate ester; Z and X are independently NH 3 , cyclic amine, alkylamino, arylamino, cycloalkylamino, and aralkylamino, or Z and X together are H 2 N-Q-NH 2 wherein Q is a divalent moiety selected from alkylene, cycloalkyl, aryl and aralkyl.