Patent ID: 8598170

Claim:
A method for treating hypertension or heart failure, comprising administering to a patient a therapeutically effective amount of a compound of formula I: where: Z is an oxazole selected from: where the amide portion of the compound of formula I is on the carbon atom between the oxygen ring atom and the nitrogen ring atom, and when Z is the R 3 moiety is on the carbon ring atom adjacent to the oxygen ring atom, and when Z is the R 3 moiety is on the carbon ring atom adjacent to the nitrogen ring atom; Ar is selected from: R 1 is selected from —COOR, —SO 2 NHC(O)R 1a , tetrazolyl, where R 1a is —C 1-6 alkyl, —C 0-6 alkylene-OR, —C 3-7 cycloalkyl, —C 0-5 alkylene-NRR, pyridyl, isoxazolyl, methylisoxazolyl, pyrrolidinyl, morpholinyl, or phenyl optionally substituted with halo; where each R is independently selected from H and —C 1-6 alkyl; a is 0, 1, or 2; R 2 is F; R 3 is selected from —C 2-5 alkyl and —O—C 1-5 alkyl; R 4 is selected from —CH 2 —SR 4a , —CH 2 —N(OH)C(O)H, —CH(R 4b )C(O)NH(OH), and —CH(R 4b )COOR 4c ; where R 4a is H or —C(O)—C 1-6 alkyl; R 4b is H or —OH; and R 4c is H or —C 1-6 alkyl; and R 5 is selected from —C 1-6 alkyl, —CH 2 -furanyl, —CH 2 -thiophenyl, benzyl, and benzyl substituted with one or more halo, —CH 3 or —CF 3 groups; where each ring in Ar is optionally substituted with 1 to 3 substituents independently selected from —OH, —C 1-6 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —CN, halo, —O—C 1-6 alkyl, —S—C 1-6 alkyl, —S(O)—C 1-6 alkyl, —S(O) 2 —C 1-4 alkyl, phenyl, —NO 2 , —NH 2 , —NH—C 1-6 alkyl and —N(C 1-6 alkyl) 2 , wherein each alkyl, alkenyl and alkenyl is optionally substituted with 1 to 5 fluoro atoms; or a pharmaceutically acceptable salt thereof.