Patent ID: 7632941

Claim:
A process for the preparation of a compound of formula (I) in which: n represents an integer from 1 to 6; m represents an integer equal to 5, 6 or 7; R 1 represents either an OH group or an —S—CH 2 —(CH 2 ) n —Z group, the R 1 groups all being identical; Z represents a group, X representing a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms and R representing a biorecognition element comprising an amino acid derivative, a peptide, a monosaccharide, an oligosaccharide, a multiplication element with several branchings comprising glucidic groups which can be identical or different, or a visualization probe or fluorescent or radioactive detection probe, said multiplication element with several branchings consisting of tris(2-hydroxymethyl)methyl radical or pentaerythritol radical, said tris(2-hydroxymethyl) radical being linked to the group Z by the quaternary carbon radical, and the pentaerythritol radical being linked to the group Z by a primary carbon radical, said process comprising the following stages: reacting a compound selectively or totally halogenated in primary alcohol position, of the following formula (VII): m being as defined above, and Y representing a halogen atom chosen from the group consisting of chlorine, bromine, and iodine, with an ω-aminoalkanethiol of the following formula (VIII): said ω-aminoalkanethiol optionally being N-alkylated, or the corresponding salt of the following formula (VIII-a): said salt being associated with a halide counter ion, n and X being as defined above, in order to obtain a compound of formula (I) as defined above and having the following formulae (A-a): and the reaction of the compound of formula (A-a) as obtained in the preceding stage with an isothiocyanate of the following formula (IX): R—N═C═S (IX) in which R is as defined above, in order to obtain a compound of formula (I) as defined above, and corresponding to the following formula: