Patent ID: 7781431

Claim:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof: wherein: A is C—C t H 2t X 2 and the dotted line indicates a bond that commences at C—C t H 2t X 2 ; B is S; Y is cyclopentyl or cyclohexyl; Ar is a moiety selected from the group consisting of phenyl, fluorophenyl, chlorophenyl, hydroxyphenyl, trifluoromethylphenyl, methoxyphenyl, difluorophenyl, methylphenyl, benzyloxyphenyl, formylphenyl, methoxychlorophenyl, dimethylaminomethylphenyl, dimethylaminoethoxyphenyl, pyridyl, furyl, oxazolyl, and thienyl; n is 0, 1 or 2; t is 0, 1 or 2; Z is a C(O)OR 10 or CONR 10 R 11 group where R 10 is hydrogen or C 1-6 alkyl and R 11 is hydrogen, C 1-6 alkyl or S(O) 2 C 1-6 alkyl; X 1 is selected from hydrogen, methoxy, C 1-6 alkyl, C 1-6 alkylC 1-6 alkoxy, carboxy, C(OH)HCH 2 NH(C 1-6 alkyl); or (i) a moiety containing at least one aromatic ring and possesses 5-, 6-, 8-, 9- or 10-ring atoms up to 4 of which may be selected from O, N or S of which not more than one may be O or S and when N is present may be a N-oxide thereof; which ring may be substituted by C 1-6 alkyl, C 4-10 aryl, C 4-10 arylC 1-6 alkyl, fluorine or chlorine; (ii) a non-aromatic ring of 3 to 8 ring atoms up to 4 of which may be selected from O, NH or S and which ring may be substituted by one or more groups selected from C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, oxo, hydroxy or tautomers thereof; (iii) CONR 4 R 5 ; or (iv) NR 6 R 7 ; X 2 is selected from hydrogen, hydroxyl and NR 6 R 7 ; R 4 is hydrogen or methyl; R 5 is hydrogen, methyl, N-oxidepyrid-4-ylmethyl, 1-methylpiperidin-3-ylmethyl or 1-methylpiperidin-4-yl; or R 4 and R 5 are joined to form a ring selected from 4-methylpiperazin-1-yl, morpholinyl, 4-pyrrolidinyl-piperazin-1-yl, dimethylaminomethyl-2-morpholin-4-yl or R 6 and R 7 are independently selected from hydrogen, C 1-6 alkyl, —CO-phenyl, —SO 2 N(C 1-6 alkyl) 2 , —(CO) 2 N(C 1-6 alky) 2 , or methyl substituted by a ring selected from cyclopropyl, phenyl, pyrid-2-yl, pyrid-4-yl, N-oxide pyrid-4-yl, 5-methyl-1,2,4-triazo-3-yl, or R 6 and R 7 and the nitrogen atom to which they are attached form a morpholinyl, pyrrolidinyl, piperazinyl or isoindolinyl ring, which ring is optionally substituted by C 1-4 alkyl or S(O) 2 C 1-4 alkyl.