Patent ID: 8143394

Claim:
A pyrido(3,2-d)pyrimidine derivative, having the structural formula: wherein: R 1 is amino, R 2 is selected from the group consisting of N-morpholinyl, N-thiomorpholinyl, N-thiomorpholinyl dioxide, mono-C 2-6 alkyl amino wherein said C 2-6 alkyl is optionally substituted with methylsulfonyl or C 1-4 alkoxy; C 1-6 alkoxy-C 1-6 alkoxy wherein said C 1-6 alkoxy is optionally substituted with a substituent selected from the group consisting of halogen and heterocyclic-oxy; R 4 is hydrogen; R 3 is a mono-substituted phenyl group substituted with —NH-Het 1 wherein said Het 1 is attached to the adjacent nitrogen atom through a carbon atom; Het 1 is a heterocyclic group; or a pharmaceutical acceptable addition salt or a stereochemical isomeric form thereof or a N-oxide thereof.