Patent ID: 8524657

Claim:
A compound of formula I(a) or pharmaceutically acceptable salts thereof, wherein Q 1 and Q 2 are each independently selected from hydrogen, C 1 -C 12 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 12 alkyloxy, nitro, halogen, hydroxyl, amino, mono or dialkylamino, carboxylic acid or a salt or ester thereof, sulphonic acid or a salt or ester thereof, phosphoric acid or a salt or ester thereof, carboxamide, sulphonamide and phosphoramide wherein each C 1 -C 12 alkyl, C 3 -C 6 cycloalkyl, or C 1 -C 12 alkyloxy is optionally substituted with hydroxyl, amino, carboxylic acid or a salt or ester thereof, sulphonic acid or a salt or ester thereof, phosphoric acid or a salt or ester thereof, carboxamide, sulphonamide or phosphoramide; B is selected from —O—, —S—, —S(O)—, —S(O) 2 —, —NH—, and —N(C 1 -C 6 alkyl)-; R 1 is selected from hydrogen, C 1 -C 12 alkyl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 6 -C 10 aryl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and a polyoxyalkylene having from 2 to 6 carbon atoms, and when B is —S—, —S(O)—, —S(O) 2 —, —NH— or —N(C 1 -C 6 alkyl)-then R 1 may be hydroxyl; V is a linker group selected from —O—, —O-L-C(O), —O-L-NR 6 —, —C(O)—, —NR 6 —, —S(O)—, —S(O) 2 —, —O-L-S(O)—, —S(O) 2 -L-C(O)—, —S(O) 2 -L-NR 6 —, and P(O) 2 O—; wherein L is selected from C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 3 -C 6 cycloalkyl, polyoxyalkylene having from 2 to 6 carbon atoms, C 6 -C 10 aryl and C 1 -C 6 alkylC 6 -C 10 aryl; and wherein R 6 is selected from H and C 1 -C 12 alkyl; A 1 and A 2 are the same or different and are basic amino acid residues wherein each basic amino acid residue has a side chain comprising an amino group or an amino group substituted on the nitrogen with up to two substituents and wherein said amino group or substituted amino group is capable of carrying a positive charge at physiological pH; each of S 1 and S 2 are absent; S 3 is an independently selected amino acid residue; and T is absent or selected from —C(O)R 8 , —C(O)OR 8 , —OR 8 , —NHR 8 , NHOR 8 , —NH—C 6 aryl-CO—R 8 , —NH—C 6 aryl-CO—NHR 8 , —NH—C 6 aryl-CONHOR 8 , —NH—C 6 aryl-CONHOH, —C(O)NHR 8 , —(NH)—SO 2 C 6 aryl, and —(NH)COR 8 , or T forms a carboxylate isostere, optionally substituted with R 8 , which replaces the carboxylic acid group of the amino acid to which T is connected; wherein R 8 is selected from hydrogen, C 1 -C 12 alkyl, C 1 -C 6 alkylC 6 -C 10 aryl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl; and wherein when T is connected to the C-terminus of an amino acid residue then the carbonyl group of the amino acid residue may be reduced to methylene.