Patent ID: 8021859

Claim:
A modified Clostridial toxin comprising: a) a Clostridial toxin enzymatic domain capable of executing an enzymatic target modification step of a Clostridial toxin intoxication process; b) a Clostridial toxin translocation domain capable of executing a translocation step of a Clostridial toxin intoxication process; c) a targeting domain comprising a polypeptide consisting of a neuroregulatory cytokine capable of executing a cell binding step of a Clostridial toxin intoxication process, wherein the neuroregulatory cytokine is glycophorin-A (GPA), onostatin M, cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), a neuroleukin, or Vascular Endothelial Growth Factor (VEGF); and d) a protease cleavage site, wherein cleavage of the protease cleavage site converts the single-chain form of the modified Clostridial toxin into the di-chain form.