Patent ID: RE41911

Claim:
A compound of the formula: wherein: Q is selected from the group consisting of: G is selected from the group consisting of alkyl; substituted alkyl; substituted aryl; a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic saturated or unsaturated ring system having between 1 and 3 heteroatoms selected from nitrogen, oxygen, and sulfur; W is O or NR 15 ; X is O or H, H; Y is selected from the group consisting of O; H, OR 16 ; OR 17 , OR 17 ; NOR 18 ; H,NHOR 19 ; H, NR 20 R 21 ; H, H; and CHR 22 ; wherein OR 17 , OR 17 can be a cyclic ketal; Z 1 and Z 2 are independently CH 2 ; B 1 and B 2 are independently selected from the group consisting of OR 24 , OCOR 25 , and O—C(═O)—NR 26 R 27 , and when B 1 is OH and Y is OH, H, they can form a six-membered ring ketal or acetal; R 1 , R 2 , R 3 , R 4 , R 5 , R 7 , R 13 , R 14 , R 18 , R 19 , R 20 , R 21 , R 22 , R 26 and R 27 are selected from the group consisting of H, alkyl, substituted alkyl, and aryl, and when R 1 and R 2 are alkyl can be joined to form a cycloalkyl, and when R 3 and R 4 are alkyl can be joined to form a cycloalkyl; R 6 is methyl; R 9 , R 10 , R 16 , R 17 , R 24 , R 25 and R 31 are selected from the group consisting of H, alkyl, and substituted alkyl; R 11 , R 12 , R 28 , R 30 , R 32 , and R 33 are selected from the group consisting of H; alkyl; substituted alkyl; aryl; substituted aryl; cycloalkyl containing 1 to 3 rings and 3 to 7 carbons per ring which may be further fused with an unsaturated C 3 -C 7 carbocyclic ring; and a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic saturated or unsaturated ring system having between 1 and 3 heteroatoms selected from nitrogen, oxygen, and sulfur; R 8 is hydrogen or methyl; R 15 , R 23 and R 29 are selected from the group consisting of H; alkyl; substituted alkyl; aryl; substituted aryl; cycloalkyl containing 1 to 3 rings and 3 to 7 carbons per ring which may be further fused with an unsaturated C 3 -C 7 carbocyclic ring; a 4 to 7 membered monocyclic, 7 to 11 membered bicyclic, or 10 to 15 membered tricyclic saturated or unsaturated ring system having between 1 and 3 heteroatoms selected from nitrogen, oxygen, and sulfur; R 32 C═O; R 33 SO 2 ; hydroxy; O-alkyl or O-substituted alkyl; or pharmaceutically acceptable salts thereof, hydrates, solvates or geometric, optical or stereoisomers thereof; with the proviso that compounds wherein W and X are both O; and R 1 , R 2 and R 7 are H; and R 3 , R 4 and R 6 are methyl; and R 8 is H or methyl; and G is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; and Q is as defined above are excluded.