Patent ID: 7304088

Claim:
A compound of formula (I): wherein X is N(R a1 ); in which R a1 is H or C 1 -C 15 alkyl; R 1 is CO 2 R b2 ; in which R b2 is H, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, aryl, heteroaryl, or C 1 -C 15 alkyl optionally substituted with halogen, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, OR b5 , CO 2 R b5 , or S(O) 2 R b5 ; R b5 being H, C 1 -C 15 alkyl, heteroaryl, or aryl; each of R 2 and R 3 , independently, is H, C 1 -C 15 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, aryl, OR c1 , SR c1 , or NR c1 R c2 ; in which each of R c1 and R c2 , independently, is H, C 1 -C 6 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, or aryl; each of R 4 and R 5 , independently, is H, halogen, C 1 -C 15 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, or aryl; one of R 6 and R 7 is C 1 -C 15 alkyl substituted with 2-oxo-3-pyrrolidinyl; and the other of R 6 and R 7 is H, C 1 -C 15 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, or aryl; R 8 is H, halogen, C 1 -C 15 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, aryl, OR d1 , or SR d1 ; in which R d1 is H and C 1 -C 15 alkyl; and one of R 9 and R 10 is C(O)R e1 ; the other of R 9 and R 10 is H, halogen, C 1 -C 15 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, aryl, C(O)R e1 , CO 2 R e1 , C(O)NR e1 R e2 , C(O)—N(R e1 )—OR e2 , C(S)R e1 , C(S)NR e1 R e2 , CN, NO 2 , S(O)R e1 , SO 2 R e1 , S(O)NR e1 R e2 , S(O)—N(R e1 )—OR e2 , S(O) 2 NR e1 R e2 ,SO 3 R e1 , PO(OR e1 ) (OR e2 ), PO(R e1 )(R e2 ), PO(NR e1 R e2 )(OR e3 ), PO(NR e1 R e2 )(NR e3 R e4 ), C(O)—N(R e1 )—NR e2 R e3 , or C(S)—N(R e1 )— NR e2 R e3 ; in which each of R e1 , R e2 , R e3 , and R e4 , independently, is H, C 1 -C 15 alkyl, C 3 -C 20 cycloalkyl, C 3 -C 20 heterocycloalkyl, heteroaryl, or aryl; or any two of R e1 , R e2 , R e3 , and R e4 , together with the atom or atoms to which they are bonded, are C 3 -C 20 heterocycloalkyl.