Patent ID: 8716193

Claim:
A method for detecting the subtype of renal cortical neoplasm present in a sample, the method comprising: (a) hybridizing said sample with a plurality of labeled probes, each of which is individually capable of hybridizing selectively to a specific marker associated with a chromosomal abnormality diagnostic or indicative of the subtype of renal cortical neoplasm, and wherein said plurality of labeled probes comprises, a probe that is capable of hybridizing selectively to 5′TFE3, a probe that is capable of selectively hybridizing to 3′TFE3, a probe that is capable of selectively hybridizing to the marker identified as D3S4208, a probe that is capable of selectively hybridizing to the marker identified as VHL, a probe that is capable of selectively hybridizing to the marker identified as D3S3634, a probe that is capable of selectively hybridizing to 7 α-satellite, a probe that is capable of selectively hybridizing to the marker identified as D17S651, a probe that is capable of selectively hybridizing to the marker identified as D3S1212; a probe that is capable of selectively hybridizing to the marker identified as D6S1941, a probe that is capable of selectively hybridizing to the marker identified as D6S2419, a probe that is capable of selectively hybridizing to the marker identified as D10S1765, a probe that is capable of selectively hybridizing to the marker identified as D1S2471, a probe that is capable of selectively hybridizing to the marker identified as D14S1007, a probe that is capable of selectively hybridizing to Y satellite III, a probe that is capable of selectively hybridizing to 5′CCND1, a probe that is capable of selectively hybridizing to 3′CCND1, a probe that is capable of selectively hybridizing to the marker identified as D5S2095, a probe that is capable of selectively hybridizing to the marker identified as D5S1469, and a control probe that is capable of being used to assess ploidy in the sample; and (b) analyzing the hybridization pattern of each of the said probes to said specific markers after said hybridization, in order to detect the presence or absence of one or more chromosomal abnormalities associated with a subtype of renal cortical neoplasm.