Patent ID: 8389771

Claim:
A method for treating an ophthalmic disease or disorder resulting at least in part from lipofuscin pigment accumulation in an eye of a subject, comprising administering to the subject a pharmaceutical composition comprising a compound having a structure of Formula (A): as a tautomer or a mixture of tautomers, or as a pharmaceutically acceptable salt, stereoisomer, or geometric isomer thereof, wherein: m is 0, 1, 2 or 3; Z is —C(R 23 )(R 24 )—C(R 1 )(R 2 )—; Y is a bond, —C(R 27 )(R 28 )—, or —C(R 27 )(R 28 )—C(R 29 )(R 30 )—; R 1 and R 2 are each independently selected from hydrogen, halogen, C 1 -C 5 alkyl, fluoroalkyl, —OR 6 or —NR 7 R 8 ; or R 1 and R 2 together form an oxo; R 23 and R 24 are each independently selected from hydrogen, halogen, C 1 -C 5 alkyl, fluoroalkyl, —OR 6 , —NR 7 R 8 ; or R 23 and R 24 together form an oxo; or optionally, R 23 and an adjacent R 1 together form a direct bond to provide a double bond; R 3 and R 4 are hydrogen; or R 3 and R 4 together form an imino; R 5 is alkyl, heteroalkyl, alkenyl, heteroalkenyl, aryl, carbocyclyl, heteroaryl or heterocyclyl; each R 6 is the same or different and independently hydrogen or C 1 -C 5 alkyl; each R 7 and each R 8 are each the same or different and independently hydrogen, alkyl, carbocyclyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, —C(═O)R 9 , SO 2 R 9 , CO 2 R 9 , SO 2 NH 2 , SO 2 NHR 9 or SO 2 N(R 9 ) 2 ; or R 7 and R 8 , together with the nitrogen atom to which they are attached, form an N-heterocyclyl; each R 9 is the same or different and each is independently methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, C 5 -C 8 alkyl, alkenyl, aryl, carbocyclyl, heteroaryl or heterocyclyl; R 12 and R 13 are the same or different and independently hydrogen, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(═O)R 9 , SO 2 R 9 , CO 2 R 9 , SO 2 NH 2 , SO 2 NHR 9 or SO 2 N(R 9 ) 2 ; each R 14 is the same or different and independently alkyl, halo, fluoroalkyl or —OR 6 ; each R 27 , R 28 , and R 29 are the same or different and independently hydrogen, alkyl or —OR 6 ; and R 30 is hydrogen or C 1 -C 5 alkyl.