Patent ID: 8133998

Claim:
A pharmaceutical composition comprising a compound of the formula: or a pharmaceutically acceptable salt or conjugate thereof in admixture with a pharmaceutically acceptable excipient, wherein each R 1 and R 2 is, independently, H, or an optionally substituted C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 heteroalkyl, C 2-6 heteroalkenyl, C 2-6 heteroalkynyl, C 6-10 aryl, C 5-12 heteroaryl, or C 6-12 aryl-C 1-6 alkyl; or R 1 and R 2 together form an optionally substituted 3-8 membered heterocyclic ring or 5-12 membered heteroaromatic ring; each R 3 and R 4 is, independently, H, halo or an optionally substituted C 1-3 alkyl or C 1-3 heteroalkyl; X is an optionally substituted C 1-3 alkylene or C 1-3 heteroalkylene; Y is Ar or N(R 5 )(R 6 ), wherein Ar is an optionally substituted C 6-10 aryl or C 5-12 heteroaryl and R 5 and R 6 are independently, H, or an optionally substituted C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 heteroalkyl, C 2-6 heteroalkenyl, C 2-6 heteroalkynyl, C 6-10 aryl, C 5-12 heteroaryl, or C 6-12 aryl-C 1-6 alkyl; or R 5 and R 6 together form an optionally substituted 3-8 membered heterocyclic ring or 5-12 membered heteroaromatic ring; wherein the optional substituents on each X, Ar, R 1 , R 2 , R 3 , R 4 and R 5 is, independently, selected from the group consisting of halo, CN, NO 2 , CF 3 , OCF 3 , COOR′, CONR′ 2 , OR′, SR′, SOR′, SO 2 R′, NR′ 2 , NR′(CO)R′, and NR′SO 2 R′, wherein each R′ is independently H or an optionally substituted group selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 heteroalkyl, C 2-6 heteroalkenyl, and C 2-6 heteroalkynyl; or the optional substituents may be one or more optionally substituted groups selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 heteroalkyl, C 2-6 heteroalkenyl, and C 2-6 heteroalkynyl; and wherein the optional substituent on X, R 1 , R 2 , R 5 and R 6 may further be selected from ═O or ═NOR′; and wherein optional substituents on a heterocyclic ring formed with R 1 and R 2 or R 5 and R 6 may independently be selected from the group consisting of ═O, ═NOR′, halo, CN, NO 2 , CF 3 , OCF 3 , COOR′, CONR′ 2 , OR′, SR′, SOR′, SO 2 R′, NR′ 2 , NR′(CO)R′, and NR′SO 2 R′, wherein each R′ is independently H or an optionally substituted group selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 heteroalkyl, C 2-6 heteroalkenyl, and C 2-6 heteroalkynyl; or the optional substituents may be one or more optionally substituted groups selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 heteroalkyl, C 2-6 heteroalkenyl, and C 2-6 heteroalkynyl, C 6-10 aryl, C 5-12 heteroaryl, and C 6-12 aryl-C 1-6 alkyl; with the following two provisos that for compounds of formula (I): when Y is N(R 5 )(R 6 ), a carbon atom in X or Y that is adjacent to the N in Y is substituted by ═O; and when Y is Ar, then neither R 1 nor R 2 are arylalkyl.