Patent ID: 8277817

Claim:
A method of treating a cancer comprising: a) obtaining a PEGylated complex comprising: (i) a therapeutic agent for the cancer, wherein the therapeutic agent is attached to a DDD (dimerization and docking domain) moiety wherein the amino acid sequence of the DDD moiety consists of the N-terminal 44 amino acids from human protein kinase A (PKA), and a PEG moiety attached to an AD (anchor domain) moiety wherein the amino acid sequence of the AD moiety is SEQ ID NO:1 or SEQ ID NO:9; or (ii) a therapeutic agent for the cancer, wherein the therapeutic agent is attached to an AD moiety wherein the amino acid sequence of the AD moiety is SEQ ID NO:1 or SEQ ID NO:9, and a PEG moiety attached to a DDD moiety wherein the amino acid sequence of the DDD moiety consists of the N-terminal 44 amino acids from human PKA RIIα; and b) administering the PEGylated complex to a subject with the cancer wherein two copies of the DDD moiety form a dimer that binds to one AD moiety to form the PEGylated complex.