Patent ID: 7507729

Claim:
A compound of formula I wherein R 1 and R 1′ are each independently hydrogen, hydroxy, lower alkyl, lower alkynyl, halogen, lower alkoxy, cycloalkyl, or lower alkyl or alkoxy each of which is substituted by halogen; X is —CH 2 —, —CH(CH 3 )—, —CH 2 —O—, —CRR′— or —C(O)—; R 2 is —(CH 2 ) n -O-lower alkyl, halogen, —NHCH 3 , —N(CH 3 )C(O)-cycloalkyl, —N(CH 3 )C(O)-lower alkyl, —N(CH 3 )S(O 2 )CH 3 , —NHC(O)CH 2 OC(O)CH 3 , —CF 3 , cycloalkyl, hydroxy, —CH 2 OH, cyano, S(O) 2 CH 3 , —CH(OH)-lower alkyl, aryl unsubstituted or substituted by lower alkoxy, an aromatic or non aromatic heterocyclic ring, containing from 1 to 3 heteroatoms selected from the group consisting of N, O and S, and wherein the heterocyclic ring is unsubstituted or substituted by 1-4 substituents selected from the group consisting of lower alkyl, lower alkoxy, cycloalkyl, ═O, CF 3 , CN, C(O)O-lower alkyl, benzyl, phenyl, —CH 2 O-lower alkyl, CHO and 3-bromo-10-chloro-9H-imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepin-6-ylmethyl, —C(O)—O-lower alkyl, —C(O)NH—(CH 2 ) n -cycloalkyl, —C(O)NH—(CH 2 ) n -aromatic or non aromatic heterocyclic ring, wherein the heterocyclic ring contains from 1 to 3 heteroatoms selected from the group consisting of N, O and S, —C(O)NH—(CH 2 ) n OH, —C(O)-aromatic or non aromatic heterocyclic ring, wherein the heterocyclic ring contains from 1 to 3 heteroatoms selected from the group consisting of N, O and S, unsubstituted or substituted by lower alkyl, —NH—C(O)H, —N(CH 3 )—C(O)H, —NH—C(O)-lower alkyl, —NH—C(O)-cycloalkyl, —NH—C(O)—O-lower alkyl, —NH—C(O)—N-di-lower alkyl, —NH—C(O)—CH 2 —O-lower alkyl, —NH—C(O)—CH 2 —OH, —NH—(CH 2 ) n -cycloalkyl, —NH—(CH 2 ) n S(O) 2 CH 3 , —NH—(CH 2 ) n -aromatic or non aromatic heterocyclic ring, wherein the heterocyclic ring contains from 1 to 3 heteroatoms selected from the group consisting of N, O and S, or —NH—(CH 2 ) n OH; or X—R 2 is lower alkyl with the exception of methyl or is cycloalkyl, which is unsubstituted or substituted by lower alkyl or hydroxy, an aromatic or non aromatic heterocyclic ring, which contains from 1 to 3 heteroatoms selected from the group consisting of N, O and S, or —CHRR′; R is hydroxy; R′ is cycloalkyl, lower alkyl, lower alkyl substituted by halogen, phenyl or pyridinyl; R 3 is hydrogen, halogen, C(O)O-lower alkyl, CH 2 OH, CHO, lower alkyl, or lower alkyl substituted by halogen; and n is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.