Patent ID: 8227494

Claim:
A pharmaceutical composition comprising a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: Z is substituted aryl, substituted or unsubstituted cycloalkyl, substituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl; R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, —(CH 2 CH 2 O) n R 6 or any biohydrolyzable group; R 2 , R 3 , R 4 and R 5 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl; substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, alkoxy, aryloxy, halogen, CF 3 , OCF 3 , OCHF 2 , CN, COOH, COOR 7 , SO 2 R 7 , NO 2 , NH 2 , or N(R 7 ) 2 ; R 6 is hydrogen or substituted or unsubstituted alkyl; each occurrence of R 7 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl; substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, alkoxy, aryloxy, halogen or CF 3 ; n is an integer from 1 to 7, with the proviso that when R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, then Z is not 2-carboxy ethyl, 3-(4-pyridinyl)propyl, 2-(4-piperidinyl) ethyl, 4-cyano-phenyl or alkyl substituted with substituted carbamyl, and a pharmaceutically acceptable carrier, excipient or diluent.