Patent ID: 8604244

Claim:
A compound of structural Formulae (I): or isomer or pharmaceutically acceptable salt thereof, wherein: n is 1; SP is a spacer of C 1-6 alkylene; X is O, S, or NH; Z is O, S, NH, or a direct bond; R 1 and R 2 are halogen; R 3 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, heteroaryl, or heteroarylalkyl; R 4 is hydrogen or alkyl; and R 5 is hydrogen, C 1-6 alkyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, heteroaryl; optionally one or more hydrogen of R 1 , R 2 , R 3 , R 4 , or R 5 is substituted with 2 H (deuterium); and “*” denotes a carbon capable of being optically active.