Patent ID: 8513210

Claim:
A DNA vaccine comprising a plasmid vector comprising a polynucleotide operatively linked to a transcriptional regulatory element wherein the polynucleotide encodes a member selected from (i) fragment of a mammalian androgen receptor consisting essentially of the ligand-binding domain defined by SEQ ID NO:9, (ii) a fragment of a mammalian androgen receptor consisting essentially of the ligand-binding domain defined by SEQ ID NO:10, (iii) a fragment of a mammalian androgen receptor consisting essentially of the ligand-binding domain defined by SEQ ID NO:11, and (iv) a fragment of a mammalian androgen receptor consisting essentially of the ligand-binding domain defined by SEQ ID NO:12, wherein upon administration of said vaccine to a mammal a cytotoxic immune reaction against cells expressing androgen receptor is induced.