Patent ID: 8569536

Claim:
A pharmaceutical composition for treating congestive heart failure, comprising, in combination, a pharmaceutically acceptable carrier and a treatment effective amount of a compound of Formula (III): wherein: R 1 is C1 -C4 alkyl and R 2 is selected from the group consisting of CCI 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CF 3 , CF 2 CF 3 , CH 2 CF 2 CF 3 , CH 2 CH 2 CF 3 , CF 2 CF 2 CF 3 , CH 2 CH 2 CH 2 CF 3 CH 2 CH 2 CF 2 CF 3 , CH 2 CF 2 CF 2 CF 3 , and CF 2 CF 2 CF 2 CF 3 ; or R 1 is selected from the group consisting of CCI 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CF 3 , CF 2 CF 3 , CH 2 CF 2 CF 3 , CH 2 CH 2 CF 3 , CF 2 CF 2 CF 3 , CH 2 CH 2 CH 2 CF 3 , CH 2 CH 2 CF 2 CF 3 ,CH 2 CF 2 CF 2 CF 3 , and CF 2 CF 2 CF 2 CF 3 and R 2 is C1-C4 alkyl; or R 1 and R 2 are each independently selected from the group consisting of CCI 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CF 3 , CF 2 CF 3 , CH 2 CF 2 CF 3 , CH 2 CH 2 CF 3 , CF 2 CF 2 CF 3 , CH 2 CH 2 CH 2 CF 3 , CH 2 CH 2 CF 2 CF 3 , CH 2 CF 2 CF 2 CF 3 , and CF 2 CF 2 CF 2 CF 3 ; or R 1 and R 2 together form a C2-C7 alkylene chain; and R 3 is selected from the group consisting of CCI 3 , CH 2 F, CHF 2 , CH 2 CF 3 ,CF 2 CF 3 , CH 2 CH 2 CF 3 , CH 2 CF 2 CF 3 , CF 2 CF 2 CF 3 , CH 2 CH 2 CH 2 CF 3 , CH 2 CH 2 CF 2 CF 3 , CH 2 CF 2 CF 2 CF 3 , CF 2 CF 2 CF 2 CF 3 , CH 2 CH 2 CH 2 CH 2 CF 3 , CH 2 CH 2 CH 2 CF 2 CF 3 , CH 2 CH 2 CF 2 CF 2 CF 3 , CH 2 CF 2 CF 2 CF 2 CF 3 , and CF 2 CF 2 CF 2 CF 2 CF 3 ; or a pharmaceutically acceptable salt or prodrug thereof.