Patent ID: 8889854

Claim:
A compound which is selected from the group consisting of: a compound of Formula I a compound of Formula II and a compound of Formula III wherein R 1 is isopropenyl or isopropyl; J and E are each independently —H or —CH 3 , and E is absent when the double bond is present; X is selected from the group of phenyl, heteroaryl ring, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, C 4-9 spirocycloalkyl, C 4-9 spirocycloalkenyl, C 4-8 oxacycloalkyl, C 4-8 dioxacycloalkyl, C 6-8 oxacycloalkenyl, C 6-8 dioxacycloalkenyl, C 6 cyclodialkenyl, C 6 oxacyclodialkenyl, C 6-9 oxaspirocycloalkyl and C 6-9 oxaspirocycloalkenyl ring; X is also selected from the group of: and for compounds of formula II and III, X is also selected from wherein X is substituted with A, and A is at least one member selected from the group of —H, -halo, -hydroxyl, —C 1-6 alkyl, —C 1-6 alkoxy, —C 1-6 haloalkyl, —NR 2 R 2 , —COOR 2 , —C(O)NR 2 R 2 , —C(O)NR 2 SO 2 R 3 , —SO 2 NR 2 R 2 , —NR 2 SO 2 R 2 , —SO 2 NR 2 R 2 , —C 1-6 cycloalkyl-COOR 2 , —C 2-6 alkenyl-COOR 2 , —C 2-6 alkynyl-COOR 2 , —C 1-6 alkyl-COOR 2 , —NHC(O)(CH 2 ) n —COOR 2 , —SO 2 NR 2 C(O)R 2 , -tetrazole, and -bicyclic heteroaryl-COOR 2 ; Y is selected from the group of —COOR 2 , —C(O)NR 2 SO 2 R 3 , —C(O)NHSO 2 NR 2 R 2 , —NR 2 SO 2 R 3 , —SO 2 NR 2 R 2 , —C 3-6 cycloalkyl-COOR 2 , —C 2-6 alkenyl-COOR 2 , —C 2-6 alkynyl-COOR 2 , —C 1-6 alkyl-COOR 2 , —NHC(O)(CH 2 ) n —COOR 2 , —SO 2 NR 2 C(O)R 2 , tetrazole, and —CONHOH, wherein n=1-6; W is —CH 2 or —CO; Z is selected from the group of: V is selected from the group of —CR 8 R 9 —, —SO 2 —, —O— and —NR 10 —; U is selected from the group of —CR 8 R 9 —, —SO 2 — and —NR 10 —; M is selected from the group of —CHR 8 R 9 , —SO 2 R 4 , —SO 2 NR 3 R 3 , —OH and —NR 10 R 11 —; R 2 is —H, —C 1-6 alkyl, -alkylsubstituted C 1-6 alkyl or -arylsubstituted C 1-6 alkyl; R 3 is —C 1-6 alkyl or -alkylsubstituted C 1-6 alkyl; R 4 is selected from the group of —C 1-6 alkyl, -alkylsubstituted C 1-6 alkyl, —C 3-6 cycloalkl, -aryl and -heteroaryl; R 5 is selected from the group of —H, —C 1-6 alkyl, -alkylsubstituted C 1-6 alkyl and —C 1-6 alkyl-OH; R 6 and R 7 are each independently selected from the group of —H, —C 1-6 alkyl, -alkylsubstituted C 1-6 alkyl, —CO 2 R 2 , —CH 2 OH, —CHF 2 and —CF 3 ; R 8 and R 9 are each independently selected from the group of —H, —C 1-6 alkyl, -alkylsubstituted C 1-6 alkyl, —SO 2 R 3 , —SO 2 NR 2 R 2 or —OH, —NR 2 R 2 , —NR 2 SO 2 R 3 , —NR 2 COR 3 and —NR 2 CONR 2 R 2 ; with the proviso that only one of R 8 and R 9 is selected from the group of —OH, —NR 2 R 2 , —NR 2 SO 2 R 3 , —NR 2 COR 3 and —NR 2 CONR 2 R 2 ; and R 10 and R 11 are each independently selected from the group of —H, —C 1-6 alkyl, -alkylsubstituted C 1-6 alkyl, —C 1-3 alkylaryl, C 1-3 alkylheteroaryl, —CO 2 R 2 and —SO 2 R 3 ; with the proviso that only one of R 10 and R 11 is selected from the group of —CO 2 R 2 and —SO 2 R 3 ; and pharmaceutically acceptable salts thereof.