Patent ID: 8193168

Claim:
A method of treating type 2 diabetes in a mammal, comprising administering to a subject in need of said treatment an effective amount of one or more compounds of Formula I: or a physiologically acceptable salt thereof, wherein R 1 is C 6-14 aryl, 5-14 membered heteroaryl, C 3-14 cycloalkyl, C 3-14 cycloalkenyl, 3-14 membered cycloheteroalkyl, 3-14 membered cycloheteroalkenyl, or C 1-6 alkyl, each of which is optionally substituted; R 2 is H, C 1-6 alkyl, or C 6-10 aryl; R 3 is H, C 1-6 alkyl, C 6-10 aryl, or cyano; R 4 is C 6-14 aryl, 5-14 membered heteroaryl, C 3-14 cycloalkyl, C 3-14 cycloalkenyl, 3-14 membered cycloheteroalkyl, or 3-14 membered cycloheteroalkenyl, each of which is optionally substituted, or is cyano; L 1 is absent, or is a linker containing 1-10 carbon atoms substituted with oxo at one carbon atom, a linker containing 2-10 carbon and heteroatoms, or a linker containing 1-10 heteroatoms, any of which is optionally substituted; and L 2 is absent, or is a linker containing 1-10 heteroatoms and which is optionally substituted; provided that when L 1 is absent, then L 2 is —N═N—, or when L′ is —C(O)—, then R 1 is C 3-14 cycloalkyl; wherein said compound is administered in an amount sufficient to treat type 2 diabetes.