Patent ID: 8232053

Claim:
A method for determining whether a colorectal tumor in a human subject is responsive to treatment with cetuximab or panitumumab comprising (i) determining the presence of a wild-type KRAS protein or a nucleic acid encoding a wild-type KRAS protein in a sample of said tumor or (ii) determining the presence of a KRAS protein with a mutation in codon 12 or 13 or a nucleic acid encoding a KRAS protein in a sample of said tumor with a mutation in codon 12 or 13; wherein (a) the presence of a wild-type KRAS protein or a nucleic acid encoding a wild-type KRAS protein indicates that the tumor in a human subject is responsive to treatment with cetuximab or panitumumab and (b) the presence of a KRAS protein with a mutation in codon 12 or 13 or a nucleic acid encoding a KRAS protein with a mutation in codon 12 or 13 indicates that the tumor in a human subject is resistant to treatment with cetuximab or panitumumab.