Patent ID: 8609089

Claim:
A method of increasing a T cell response in a human subject comprising administering to the subject an anti-B7-H1 antibody or an antigen binding fragment thereof in combination with a potentiating agent selected from the group consisting of cyclophosphamide and an analog of cyclophosphamide, wherein the administration of the anti-B7-H1 antibody or antigen binding fragment thereof in combination with the potentiating agent increases a T cell response, wherein the dose of the potentiating agent is less than 200 mg/kg, wherein the dose of the potentiating agent is not effective to have direct anti-tumor activity, and wherein the T cell response achieved by the combination of the anti-B7-H1 antibody and the potentiating agent is greater than the T cell response achieved by administering either the anti-B7-H1 antibody alone or the potentiating agent alone.