Patent ID: 7045636

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or solvate of said compound, wherein: X is a single bond, —C—, —CH—or alkylene, and when X is a single bond, R 6 is absent and the carbon atom marked 1 is directly attached to N of N—Y; Y is a single bond, —C—, —CH—or alkylene, and when Y is a single bond, R 5 is absent and the carbon atom marked 7 is directly attached to N of N—X; R 1 is aryl or heteroaryl, wherein each of said aryl or heteroaryl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of CN, CF 3 , halogen, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxy, alkoxy and OH; R 2 is H, alkyl, aryl or aralkyl wherein each of said aryl or aralkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxy, alkoxy and OH; R 3 is H, alkyl, aryl or aralkyl wherein each of said aryl or aralkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of CF 3 , halogen, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxy, alkoxy and OH; R 4 is selected from the group consisting of wherein each R 7 in said —N(R 7 ) 2 , can be the same or different and each R 7 is H, alkyl, cycloalkyl or aryl, wherein each of said alkyl, aryl or cycloalkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxy, alkoxy and OH; or each R 7 can be joined together and with the nitrogen to which they are attached to form a 3 to 7-membered heterocyclyl ring; n is 0; p is 0 to 5 and when p is >1, the number of p moieties can be the same or different; R 5 is H or 1 or 2 substituents independently selected from alkyl or cycloalkyl; R 6 is H or 1 or 2 substituents independently selected from alkyl or cycloalkyl; and R 8 is H, OH, alkoxy, alkyl, cycloalkyl, aryl, —N(H)R 7 , —N(H)C(O)alkyl, —N(H)C(O)aryl, —N(H)C(O)N(H)alkyl, —N(H)C(O)N(H)aryl, —N(H)S(O 2 )alkyl or —N(H)S(O 2 )aryl; with the proviso that the carbons shown marked 1 and 6 on the aromatic ring, along with X—R 6 , can optionally form a 4 to 8 membered ring system.