Patent ID: 7169759

Claim:
A compound of formula 1 wherein A is a straight or branched chain alkanoxy or alkenoxy of 1 to 5 carbon atoms, aryl, arylalkyl, the aryl being optionally substituted with 1 to 2 carbon atoms or halogen, adamantyloxy, or 4-aminobutanoic acid; B is selected from the group consisting of hydroxy, wherein a dithered line represents a point of attachment at B of formula 1; D is H or an oxo group; L is a 5 or 6 membered saturated, unsaturated or aromatic heterocycle having from 1 to 3 heteroatoms chosen from nitrogen, oxygen and sulfur, or a saturated, unsaturated or aromatic carbocycle of 3 to 6 carbon atoms, any group represented by L having optional substitution with R′, OR′, or halogen; Q is a bond, or is a straight chain linking group of 1 to 3 non-hydrogen atoms chosen from the group consisting of —CH 2 —, —O—, and —NH— wherein O and N may not be adjacent; ring M is a stable 5 to 7-membered saturated, unsaturated or aromatic heterocycle having up to 2 additional N atoms and optionally having 1 to 2 atoms of O and S, T is independently selected from the group consisting of H, OH, NO 2 , C(O)N(R) 2 , F, C 1 –C 3 alkoxy, hydroxymethyl and CF 3 , wherein at least one T is other than H; x is an integer of 1 to 3, y is an integer of 1 to 6, z is 0 (zero), 1 or 2, R′ is independently H, —OH, C 1 –C 2 alkyl or phenyl, R is independently H, C 1 –C 4 alkyl, or phenyl, and E is H, or C 1 –C 2 alkyl; R 1 is C 1 –C 5 alkyl; R 2 is 2-propyl, 1-(2-methylpropyl)- or phenyl optionally substituted with R′, OR′ or halogen; R 3 is phenyl, C 1 –C 5 alkyl, or 1-(2-methylthio-)ethyl-; R 4 is 2-propyl, 2-butyl or 2-methylpropyl; and stereoisomers, hydrates and pharmaceutically acceptable salts and esters thereof.