Patent ID: 8268846

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt, wherein: X is NH, NCH 3 , or O; Y is N or CR 8 ; Z is N or CR 9 ; R 1 is selected from hydrogen, NH 2 , alkyl, or fluoroalkyl; R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, alkylcycloalkyl, carboxy, cyano, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, fluoroalkoxy, fluoroalkyl, fluorocycloalkyl, fluorocycloalkylalkyl, fluorine, formyl, haloalkoxy, hydroxyalkyl, and C(O)NR 10 R 11 ; or R 2 and R 3 , or R 4 and R 5 , or R 6 and R 7 taken together are —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 CH 2 —, —CH 2 CH 2 OCH 2 CH 2 —, —CH 2 OCH 2 CH 2 —, or —OCH 2 CH 2 CH 2 —; or R 3 and R 4 , or R 5 and R 6 taken together are —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, or —CH 2 OCH 2 —; R 8 and R 9 are each independently selected from the group consisting of hydrogen, fluoroalkyl, and halogen; R 10 and R 11 are each independently selected from the group consisting of hydrogen and alkyl; G 1 and G 2 are taken together to form groups of formula (ii) or formula (iv) L is selected from O, S, NH, or N—CH 3 ; R 12 and R 13 are each independently selected from the group consisting of hydrogen, alkyl, aryl, and arylalkyl; R 14 , R 15 , R 16 , and R 17 are each independently selected from the group consisting of hydrogen, acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcycloalkyl, alkylsulfonyl, alkylthio, alkynyl, amido, aryl, halogen, fluoroalkyl, carboxy, cyano, cyanoalkyl, cycloalkoxyalkyl, cycloalkyl, fluoroalkoxy, fluorocycloalkyl, fluorocycloalkylalkyl, formyl, haloalkoxy, haloalkyl, heteroaryl, heterocycle, hydroxy, hydroxyalkyl, mercapto, nitro, C(O)NR 25 R 26 , NR 25 C(O)alkyl, —NR 26 C(O)Oalkyl, N(R 25 )SO 2 (R 26 ), —NR 25 R 26 , O-aryl, O-heteroaryl, S-aryl, and —SO 2 (NR 25 R 26 ); or R 15 and R 16 taken together are: —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, —CH 2 OCH 2 —, or —OCH 2 CH 2 —; R 25 and R 26 are independently selected from the group consisting of hydrogen, acyl, alkoxyalkyl, alkyl, aryl, arylalkyl, cyanoalkyl, cycloalkyl, cycloalkoxyalkyl, cycloalkylalkyl, fluoroalkyl, fluorocycloalkylalkyl, and hydroxyalkyl; m is 0, or 1; and n is 0, 1, 2, or 3.