Patent ID: 8399488

Claim:
A compound of formula I: wherein: a is 0 or 1; R 1 is -halo; b is 0 or 1; R 2 is -halo; W is —O—; c is 0; m is 0 or 1; Z is selected from —C(O)N(R 4 )— and —N(R 4 )C(O)—, where R 4 is selected from —H, —C 1-5 alkyl, and —C 3-5 cycloalkyl; s is 0, 1 or 2; Ar is a C 3-5 heteroarylene group selected from pyridylene, thienylene, pyrrolylene, and furylene; t is 0, 1 or 2; R 6 is selected from —H, —C 1-5 alkyl, and —X 6 R 6a ; where X 6 is —C 1-5 alkylene and R 6a is selected from —OH, —C 1-5 alkoxy and -heteroaryl; and R 7 is selected from —H, —C 1-5 alkyl, —C 3-6 cycloalkyl, and —X 7 R 7a ; where X 7 is selected from —C 1-5 alkylene, —C(O)—, —C 1-5 alkylene-C(O)—, —S(O 2 )—, —C 1-5 alkylene-S(O 2 )—, and —S(O 2 )—C 1-5 alkylene; and R 7a is selected from —OH, —C 1-5 alkyl, —C 3-6 cycloalkyl, —C 1-5 alkoxy, heteroaryl, —NR 7b R 7c , where R 7b and R 7c are independently —H or —C 1-5 alkyl, and aryl optionally substituted with 1-2-C 1-5 alkyl or halo groups; wherein each alkyl and alkoxy group in R 6 , R 6a , R 7 , and R 7a-c is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.