Patent ID: 7022691

Claim:
A compound of formula (I): wherein R 1 and R 2 are H R 3 is hydrogen, carboxy, (C 1 –C 10 )alkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, (C 1 –C 10 )alkanoyl, (C 3 –C 8 )cycloalkyl, aryl, heteroaryl, alkyl arylakyl, alkoxycarbonyl, oxazolinyl, isoazolidinyl, morpholinyl, heteroarylcarbonyl, alkanoyloxy, or alkoxy; or —CH 2 R a wherein R a is halo, cyano, cyanato, —OR b , —NR c R d , azido, —SR e , O—CO—R f , aryl, heteroaryl, (C 3 –C 8 )cycloalkyl, oxazolinyl, isoazolidinyl, morpholinyl, heteroarylcarbonyl, alkanoyloxy, or alkoxy; R 4 is hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, alkoxycarbonyl, aryl, heteroaryl, arylalkyl, oxazolinyl, isoazolidinyl, morpholinyl, heteroarylcarbonyl, or alkoxy; n is 0, 1, or 2; R b is hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, —C(═O)N(R f ) 2 , aryl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, or (C 1 –C 10 )alkanoyl, wherein each R f is independently hydrogen, (C 1 –C 10 )alkyl, aryl, benzyl, phenethyl, or heteroaryl; each R c or R d is independently hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, (C 1 –C 10 )alkanoyl, —C(═O)N(R f ) 2 , aryl, benzyl, phenethyl, heteroaryl, oxazolidinyl, isoxazolidinyl, or morpholinyl, wherein each R f is independently hydrogen, (C 1 –C 10 )alkyl, aryl, benzyl, phenethyl, or heteroaryl; or R c and R d together with the nitrogen to which they are attached are triazolyl, imidazolyl, oxazolidinyl, isoxazolidinyl, pyrrolyl, morpholino, piperidino, pyrrolidino, pyrazolyl, indolyl, or tetrazolyl; and R e is hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, cyano, aryl, benzyl, phenethyl, heteroaryl, oxazolidinyl, isoxazolidinyl, or morpholinyl; wherein any (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, (C 1 –C 10 )alkanoyl, aryl, benzyl, phenethyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, oxazolidinyl, isoxazolidinyl, or morpholinyl of R 1 –R 4 , R a –R e , or R f –R g , may optionally be substituted with 1, 2, or 3 Z; and each Z is independently halo, nitro, cyano, hydroxy, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 1 –C 10 )alkoxy, (C 1 –C 10 )alkanoyl, (C 2 –C 10 )alkanoyloxy, trifluoromethyl, aryl, aryloxy, or heteroaryl; or a pharmaceutically acceptable salt thereof.