Patent ID: 8263041

Claim:
A method of delivering a molecule to the neovasculature of tumour metastases in a human or animal comprising administering to the human or animal an antibody which binds the ED-A isoform of fibronectin comprising: a VH domain comprising a framework and a set of complementarity determining regions HCDR1, HCDR2 and HCDR3, wherein: HCDR1 has the amino acid sequence of SEQ ID NO:83, HCDR2 has the amino acid sequence of SEQ ID NO: 4, and HCDR3 has the amino acid sequence of SEQ ID NO: 5, and a VL domain comprising a framework and a set of complementarity determining regions LCDR1, LCDR2 and LCDR3, wherein: LCDR1 has the amino acid sequence of SEQ ID NO:86, LCDR2 has the amino acid sequence of SEQ ID NO: 7, and LCDR3 has the amino acid sequence of SEQ ID NO: 8; wherein the antibody is conjugated to the molecule.