Patent ID: 7622107

Claim:
A prime-boost vaccine strategy for protecting a mammal against infection by a pathogen of the genus Mycobacterium comprising: administering a first priming immunogenic composition to a vaccinee wherein said first priming immunogenic composition is a Bacille Calmette Guèrin (BCG); and administering a second boosting immunogenic composition, after the passage of a period of time, to said vaccinee optionally in the presence of an adjuvant, wherein said second boosting immunogenic composition comprises at least one purified Mycobacteria major extracellular protein selected from the group consisting of Mycobacterium tuberculosis (Mtb) 23.5 kDa protein, Mtb 30 kDa protein (Ag85B), Mycobacterium bovis (MB) 30 kDa protein, Mycobacterium leprae (ML) 23.5 kDa protein, and ML 30 kDa protein; wherein a protective immune response against said pathogen of the genus Mycobacterium is produced in said vaccinee.