Patent ID: 7067539

Claim:
A compound of the formula or a pharmaceutically acceptable salt or solvate thereof; wherein: R 1 is selected from the group consisting of H, alkyl, haloC 1 –C 6 alkyl, cycloalkyl, cycloalkylNH—, arylalkyl, heterocycloalkyl, heteroaryl, —N(R 2 ) 2 , —N(R 2 )aryl, unsubstituted aryl and aryl substituted with one to three X, wherein each R 2 can be the same or different and is independently selected when there are more than one R 2 present; R 2 is selected from the group consisting of H and C 1 –C 6 alkyl; R 3 is 1–3 substituents selected from the group consisting of H, C 1 –C 6 alkyl, Cl, F, CF 3 , OCF 2 H, OCF 3 , OH and C 1 –C 6 alkoxy, wherein R 3 can be the same or different and is independently selected when there are more than one R 3 present; R 4 is pyridine-N-oxide or pyridyl optionally substituted with one to three X, wherein X can be the same or different and is independently selected when there are more than one X present; R 5 is H or C 1 –C 6 alkyl; R 6 is H or C 1 –C 6 alkyl; or R 5 and R 6 taken together with the carbon atom to which they are attached form a carbonyl group; L 1 is —SO 2 —, —SO—, or —S—; L 2 is —SO 2 —, —SO—, or —S—; X is selected from the group consisting of H, halogen, CF 3 , CN, OCF 2 H, OCF 2 CF 3 , OCF 3 , OR 2 , C 1 –C 6 alkyl, cycloalkyl, cycloalkoxy, C 1 –C 6 alkoxy, alkoxyC 1 –C 6 alkoxy, O-cycloalkyl, cycloalkylamino, cycloalkylalkoxy, heteroalkyl, —OSO 2 R 2 , —COOR 2 , —CON(R 2 ) 2 , N(R 2 ) 2 , and NR 2 aryl, wherein X can be the same or different, and is independently selected when there are more than one X present; Y is a covalent bond, —CH 2 —, —SO 2 —, or —C(O)—; Z is a covalent bond, —CH 2 —, —SO 2 — or —C(O)—; or Y, R 1 , Z and R 2 can be taken together with the nitrogen atom to which they are attached to form a heterocycloalkyl; with the following provisos: L 2 and R 4 , when taken together, cannot have two heteroatoms covalently bonded together; when R 2 is H, Z cannot be —S(O)—, —SO 2 —, or —C(O)—; and when Y is a covalent bond, R 1 cannot form a N—N bond with the nitrogen atom.