Patent ID: 7868204

Claim:
A histone deacetylase inhibitor of formula (2): or a pharmaceutically acceptable salt thereof, wherein Cy 2 is optionally substituted aryl; X 1 is M 2 -L 2 wherein L 2 , at each occurrence, is independently selected from the group consisting of a chemical bond, C 1 -C 4 alkylene, C 2 -C 4 alkenylene, and C 2 -C 4 alkynylene; M 2 is selected from the group consisting of M 1 and heteroarylene, which heteroarylene ring is optionally substituted; M 1 is selected from the group consisting of —O—, —N(R 7 )—, —S—, —S(O)—, S(O) 2 —, —S(O) 2 N(R 7 )—, —N(R 7 )—S(O) 2 —, —C(O)—, wherein R 7 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, acyl, heterocyclyl, and heteroaryl; and Ar 2 is optionally substituted arylene; q is 0; and Ay 2 is a phenyl, a 5-6 membered cycloalkyl, heterocyclyl, or heteroaryl substituted with an amino or hydroxy moiety and further optionally substituted; provided that (a) when Ay 2 is o-phenol optionally substituted by halo, nitro, or methyl, Ar 2 is optionally substituted phenyl, X 1 is —O—, —S—, —S—CH 2 —, —S(O)—, —S(O) 2 —, —C(O)—, or —OCH 2 —, then Cy 2 is not optionally substituted phenyl or naphthyl; (b) when Ar 2 is amino or hydroxy substituted phenyl, X 1 is C 0 -C 8 -alkyl-X 1a —C 0 -C 8 -alkyl, wherein X 1a is —O—, —S—, —NH—, —C(O)—, then Cy 2 is not optionally substituted naphthyl or di- or -tetrahydronaphthalene.