Patent ID: 7153855

Claim:
A compound of formula (I): wherein: R 1 is selected from the group consisting of halo, —NR 7 R 8 , Ay, —NR 7 Ay, Het, —NHR 10 Het, —NHHet and —NHR 10 Ay; each R 7 and R 8 are the same or different and are independently selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, —R 10 cycloalkyl, —R 10 OR 9 , —NR 9 R 11 , —R 10 NR 9 R 11 , —R 10 C(O)R 9 , —C(O)R 9 , —C(O)R 10 Ay, —C(O)R 10 Het, —CO 2 R 9 , —R 10 CO 2 R 9 , —C(O)NR 9 R 11 , —R 10 C(O)NR 9 R 11 , —R 10 C(O)Ay, —R 10 C(O)Het, —C(S)NR 9 R 11 , —R 10 C(S)NR 9 R 11 , —R 10 NHC(NH)NR 9 R 11 , —R 10 NHC(O)R 10 Het, —R 10 NHC(O)R 10 CO 2 R 9 , —R 10 NHC(NCO 2 R 9 )NHCO 2 R 9 , —R 10 NHC(O)NHSO 2 R 9 , —R 10 NHC(O)NHSO 2 Ay, —R 10 NHC(O)NHSO 2 Het, —R 10 C(NH)NR 9 R 11 , —C(NH)NR 9 R 11 , —SO 2 NR 9 R 11 , —R 10 SO 2 NR 9 R 11 , —R 10 NHSO 2 R 9 , —SO 2 R 10 , —R 10 SO 2 R 10 , —R 10 NHCOR 9 , —R 10 SO 2 NHCOR 9 , —R 10 NHP(O)(OR 9 ) 2 , —R 10 OP(O)(OR 9 ) 2 and —R 10 OP(O)(OR 10 Ay) 2 ; each R 9 and R 11 are the same or different and are independently selected from the group consisting of H, alkyl, cycloalkyl, —R 10 cycloalkyl, —R 10 OH, —R 10 (OR 10 ) w where w is 1–10, and —R 10 NR 10 R 10 ; each R 10 is the same or different and is independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl and alkynyl; Ay is aryl; Het is a 5- or 6-membered heterocyclic or heteroaryl group; R 2 is selected from the group consisting of halo, alkyl, cycloalkyl, alkenyl, cycloalkenyl, —NR 7 R 8 , —OR 7 , —OAy, —S(O) n R 9 , —S(O) n Ay, —R 10 NR 7 R 8 , —R 10 NR 7 Ay, Ay, Het, —NHHet, —NHR 10 Het, —OHet and —OR 10 Het; n is 0, 1 or 2; Y is N; R 3 and R 4 are the same or different and are each independently selected from the group consisting of H, halo, alkyl, cycloalkyl, alkenyl, Ay, —OR 7 , —OAy, —R 10 OR 7 , —R 10 OAy, —NR 7 R 8 , —NR 7 Ay, —R 10 NR 7 R 8 , —R 10 NR 7 Ay, —C(O)R 7 , —C(O)Ay, —CO 2 R 7 , —CO 2 Ay, —SO 2 NHR 9 , Het, —NHHet and —NHR 10 Het; q is 0, 1, 2, 3, 4 or 5; and each R 5 is the same or different and is independently selected from the group consisting of halo, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, —R 10 cycloalkyl, Ay, —NHR 10 Ay, Het, —NHHet, —NHR 10 Het, —OR 7 , —OAy, —OHet, —R 10 OR 9 , —NR 7 R 8 , —NR 7 Ay, —R 10 NR 7 R 8 , —R 10 NR 7 Ay, —R 10 C(O)R 9 , —C(O)R 9 , —CO 2 R 9 , —R 10 CO 2 R 9 , —C(O)NR 7 R 8 , —C(O)Ay, —C(O)NR 7 Ay, —C(O)Het, —C(O)NHR 10 Het —R 10 C(O)NR 9 R 11 , —C(S)NR 9 R 11 , —R 10 C(S)NR 9 R 11 , —R 10 NHC(NH)NR 9 R 11 , —C(NH)NR 7 R 8 , —C(NH)NR 7 Ay, —R 10 C(NH)NR 9 R 11 , —S(O) 2 NR 7 R 8 , —S(O) 2 NR 7 Ay, —R 10 SO 2 NHCOR 9 , —R 10 SO 2 NR 9 R 11 , —R 10 SO 2 R 9 , —S(O) n R 9 , cyano, nitro and azido; or two adjacent R 5 groups together with the atoms to which they are bonded form a C 5-6 cycloalkyl or aryl; wherein when q is 1 and R 5 is in the para position, R 5 is not halo; and or a pharmaceutically acceptable salt thereof.