Patent ID: 7858644

Claim:
A method of treating a condition alleviated by antagonism of an EP4 receptor, which method comprises administering to a patient in need thereof a compound of the formula (I) or a pharmaceutically acceptable salt thereof wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S,S(═O) or S(═O) 2 R 3 is an optionally substituted C 6 aryl group linked to a further optionally substituted C 6 aryl group, wherein each optionally substituted C 6 aryl group has 6 ring atoms, which ring atoms may be all carbon atoms or may include one or more heteroatoms; and wherein if both optionally substituted C 6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C 1-3 alkylene group; and R 5 is either: (i) carboxy (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is an optionally substituted C 5-7 aryl group having from 5 to 7 ring atoms, which ring atoms may be all carbon atoms or may include one or more heteroatoms, or an optionally substituted C 5-7 arylC 1-7 alkyl group wherein said C 5-7 arylC 1-7 alkyl group has from 5 to 7 ring atoms, which ring atoms may be all carbon atoms or may include one or more heteroatoms; (iv) tetrazole-5-yl, and Wherein the condition to be treated is selected from the group consisting of pain, inflammatory disease, cancer, bone disorders involving altered bone formation or resorption; myometrial and endometrial disorders; gastrointestinal disease; immunological disorders; diseases of abnormal platelet function; impotence, erectile dysfunction, and female sexual dysfunction; hair growth disorders; sleep disorders; cardiovascular diseases and shock states associated with hypotension; neurodegenerative diseases; for preventing neuronal damage following stroke, cardiac arrest, cardiopulmonary bypass, traumatic brain injury or spinal cord injury; tinnitus; dependence; and complications of diabetes; or wherein the compound of the formula (I) is used as a diuretic.