Patent ID: 7074770

Claim:
A method of vaccinating a mammal against a disease state, comprising administrating to said mammal, within an appropriate vector, a nucleotide sequence encoding an antigenic peptide associated with the disease state and not associated with a virus particle; additionally administering to said mammal a Schiff base forming compound which enhances both humoral and cellular immune responses initiated by the antigenic peptide, the compound being selected from the group consisting of: 4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid; 5-(2-formyl-3-hydroxyphenoxy)pentanamide; N,N-diethyl 5-(2-formyl-3-hydroxyphenoxy)pentanamide; N-isopropyl 5-(2-formyl-3-hydroxyphenoxy)pentanamide; ethyl 5-(2-formyl-3-hydroxyphenoxy)pentanoate; 5-(2-formyl-3-hydroxyphenoxy)pentanonitrile; (Â±)-5-(2-formyl-3-hydroxyphenoxy)-2-methylpentanoic acid; 5-(2-formyl-3-hydroxyphenoxy)-2,2-dimethylpentanoic acid; methyl 3-(2-formyl-3-hydroxyphenoxy)methylbenzoate; 3-(2-formyl-3-hydroxyphenoxy)methylbenzoic acid; benzyl 5-(2-formyl-3-hydroxyphenoxy)pentanoate; 5-[4-(2-formyl-3-hydroxyphenoxy)-N-butyl]tetrazole; 7-(2-formyl-3-hydroxyphenoxy)heptanoic acid; 5-(2-formyl-3-hydroxy-4-n-propoxyphenoxy)pentanoic acid; 5-(4,6-dichloro-2-formyl-3-hydroxyphenoxy)pentanoic acid; 5-(2-formyl-3-hydroxyphenoxy)-N-methylsulphonylpentanamide; ethyl 4-(2-formyl-3-hydroxyphenoxymethyl)benzoate; 5-(4-chloro-2-formyl-3-hydroxyphenoxy)pentanoic acid; 5-(3-acetylamino-2-fomyl phenoxy)pentanoic acid; Aminoguanidine; 4-(2-formyl-3-hydroxyphenoxy)butanoic acid; 6-(2-formyl-3-hydroxyphenoxy)hexanoic acid; ethyl 4-(3-acetylaminio-2-formylphenoxymethyl)benzoate; 4-(3-acetylamino-2-formylphenoxymethyl)benzoic acid; 2-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid; 5-[4-(2-formyl-3-hydroxyphenoxymethyl)phenyl]tetrazole; 5-(2-formyl-3-hydroxy-4-methoxyphenoxy)pentanoic acid; 3-(2-formyl-3-hydroxyphenoxy)propionitrile; 4-Hydroxyphenylacetaldehyde; Phenylacetaldehyde; 4-Methoxyphenylacetaldehyde; 1-hydroxy-2-phenylpropane; 3-Phenylproponionaldeyde; 4-Nitrobenzaldehyde; Methyl 4-formylbenzoate; 4-Chlorobenzaldehyde; 4-Methyloxybenzaldehyde; 4-Methylbenzaldehyde; 8,10-Dioxoundecanoic acid; 4,6-Dioxoheptanoic acid; Pentanedione; 5-methoxy-1-tetralone; 6-methoxy-1-tetralone; 7-methoxy-1-tetralone; 2-tetralone; 3-hydroxy-1-(4-methoxyphenyl)-3-methyl-2-butanone; 2â€²,4â€²-dihydroxy-2-(4-methoxyphenyl)acetophenone; 2-hydroxy-1-(4-methyoxyphenyl)-pent-2ene-4one; Naringenin 4â€²,5,6-trihydroxyflavonone; 4â€²-methoxy-2-(4-methoxyphenyl)acetophenone; 6,7-dihydroxycoumarin; 7-methoxy-2-tetralone; 6,7-dimethoxy-2-tetralone; 6-hydroxy-4-methylcoumarin; Homogentisic acid gamma lactone; 6-hydroxy-1,2-naphthoquinone; 8-methoxy-2-tetralone; and physiologically acceptable salts thereof, where appropriate.