Patent ID: 7482350

Claim:
A compound according to Formula I or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted alkoxy, optionally substituted cycloalkoxy, optionally substituted (cycloalkyl)alkoxy, and optionally substituted heterocycloalkyl; R 2 is selected from —XR A , —(CR A R B )OR 4 , —CR A R B NR 4 R 5 and —CR A R B Q; R 3 is optionally substituted heterocycle, wherein said heterocycle is an optionally substituted piperazine; R 4 is: (i) C 2 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, mono- or di-(C 1 -C 4 alkylamino)C 2 -C 4 alkyl, (3- to 7-membered heterocycloalkyl)C 0 -C 4 alkyl, arylC 0 -C 4 alkyl, or heteroarylC 0-4 alkyl, each of which is optionally substituted; or (ii) joined to R 5 to form, with the nitrogen to which R 4 and R 5 are bound, a heterocycle having from 1 to 3 rings, 5 to 7 ring members in each ring, and is optionally substituted; R 5 is: (i) hydrogen; (ii) C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 7 carbocycle)C 0 -C 4 alkyl, each of which is optionally substituted; or (iii) joined to R 4 to form an optionally substituted heterocycle; Ar is mono-, di-, or tri-substituted phenyl, optionally substituted naphthyl, or optionally substituted heteroaryl having from 1-to 3 rings, 5 to 7 ring members in each ring; R A and R B , which may be the same or different, are independently selected at each occurrence from: (i) hydrogen and hydroxy; and (ii) alkyl groups, cycloalkyl groups, and (cycloalkyl)alkyl groups, each of which is optionally substituted with one or more substituent(s) independently selected from oxo, hydroxy, halogen, cyano, amino, C 1-6 alkoxy, —NH(C 1-6 alkyl), —N(C 1-6 alkyl)(C 1-6 alkyl), —NHC(═O)(C 1-6 alkyl), —N(C 1-6 alkyl)C(═O)(C 1-6 alkyl), —NHS(O) n (C 1-6 alkyl), —S(O) n (C 1-6 alkyl), —S(O) n NH(C 1-6 alkyl), —S(O) n N(C 1-6 alkyl)(C 1-6 alkyl), and Z; X is independently selected at each occurrence from —CHR B —, —O—, —C(═O)—, —C(═O)O—, —S(O) n —, —NR B —, —C(═O)NR B —, —S(O) n NR B —, —NR B C(═O)—, and —NR B S(O) n —; Y and Z are independently selected at each occurrence from 3- to 7-membered carbocyclic or heterocyclic groups which are saturated, unsaturated, or aromatic, which are optionally substituted with one or more substituents independently selected from halogen, oxo, hydroxy, amino, cyano, C 1-4 alkyl, C 1-4 alkoxy, mono- or di-(C 1-4 alkyl)amino, and —S(O) n (alkyl); Q is an optionally substituted carbocyclic or optionally substituted heterocyclic group which are saturated, unsaturated or aromatic and comprises between 3 and 18 ring atoms arranged in 1, 2, or 3 rings which are fused, spiro or coupled by a bond; m is independently selected at each occurrence from integers ranging from 0 to 8; and n is an integer independently selected at each occurrence from 0, 1, and 2.