Patent ID: 7262195

Claim:
A compound of the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomers thereof; wherein R 1 and R 2 are the same or different and are independently selected from hydrogen, alkyl, aryl, cycloalkyl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl; Z is selected from —CON(R 4 )R 4a , —CO 2 R 4 , —SO 2 N(R 4 )R 4a , —SO 2 R 4 , CN, and R 4 and R 4a are the same or different and are independently selected from hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, or R 4 and R 4a can be joined together to form a heterocycle; R 4b is selected from hydrogen, halogen, hydroxyl, CN, OCF 3 , CF 3 , CONH 2 , SONH 2 , SO 2 CH 3 , NHCOCH 3 or NHCO 2 CH 3 ; Q is a substituted bicyclic heterocycle selected from wherein r is 0, 1 or 2; and represents a single bond or a double bond; and T is selected from alkyl, aryl, cycloalkyl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl, and where each of these groups may be optionally substituted with R 5 , R 5a , and R 5b ; R 5 , R 5a and R 5b are the same or different and are independently selected from hydrogen, halogen, hydroxyl, OCF 3 , CF 3 , CN, NR 5c (R 5d ), C(O)NR 5c (R 5d ), OC(O)N(R 5c )R 5d , OR 5c , SO 2 R 5c , SO 2 N(R 5c )R 5d , alkyl, alkoxyl, aryl, arylalkyl, or heteroaryl; or R 5 and R 5a can be joined together with —OCH 2 O— or —OCH 2 CH 2 O— to form a fused bicyclic ring with aryl or a heteroaryl group; R 5c and R 5d are the same or different and are independently selected from hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, or heterocycloalkyl or R 5c and R 5d can be joined together to form a heterocycle.