Patent ID: 8912146

Claim:
A composition comprising a derivative of antiproliferative factor (APF) having a disaccharide linked to a peptide moiety wherein: the peptide moiety is TVPAAVVVA (SEQ ID NO: 1), wherein the proline at position 3 is substituted with the proline mimetic D pipecolic acid, L-pipecolic acid, hydroxyproline, O-t-butyryl-trans-4-hydroxyproline, N-methylalanine, nipecotic acid, isonipecotic acid, 3-methylproline, 2-methylproline, or 2,4-CH 2 -proline; the disaccharide comprises β-galactose and N-acetyl galactosamine; and the N-acetyl glactosamine is O-linked to the N-terminal threonine of the peptide moiety in the alpha configuration.