Patent ID: 8383628

Claim:
A compound of formula (III): wherein: x and y are each independently 1, 2 or 3; V a is —C(O)—, —C(S)—, —C(O)N(R 1 )—, —C(O)O—, —S(O) 2 — or —S(O) 2 N(R 1 )—; each R 1 is independently selected from the group consisting of hydrogen, C 1 -C 12 alkyl, C 2 -C 12 hydroxyalkyl, C 4 -C 12 cycloalkylalkyl and C 7 -C 19 aralkyl; R 2 is selected from the group consisting of C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl, C 1 -C 6 alkoxy, C 3 -C 12 alkoxyalkyl, C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, aryl, C 7 -C 19 aralkyl, C 3 -C 12 heterocyclyl, C 3 -C 12 heterocyclylalkyl, C 1 -C 12 heteroaryl and C 3 -C 12 heteroarylalkyl; or R 2 is a multi-ring structure having 2 to 4 rings wherein the rings are independently selected from the group consisting of cycloalkyl, heterocyclyl, aryl and heteroaryl, where some or all of the rings may be fused to each other; R 3 is phenyl optionally substituted by one or more substituents selected from the group consisting of halo, cyano, nitro, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 trihaloalkyl, C 1 -C 6 trihaloalkoxy, C 1 -C 6 alkylsulfonyl, —N(R 12 ) 2 , —OC(O)R 12 , —C(O)OR 12 , —S(O) 2 N(R 12 ) 2 , cycloalkyl, heterocyclyl, heteroaryl and heteroarylcycloalkyl; R 4 , R 5 and R 6 are each independently selected from hydrogen, fluoro, chloro, methyl, methoxy, trifluoromethyl, cyano, nitro or —N(R 13 ) 2 ; R 7 , R 7a , R 8 , R 8a , R 9 , R 9a , R 10 , and R 10a are each independently selected from hydrogen or C 1 -C 3 alkyl; or R 7 and R 7a together, or R 8 and R 8a together, or R 9 and R 9a together, or R 10 and R 10a together are an oxo group, provided that when V a is —C(O)—, R 7 and R 7a together or R 8 and R 8a together do not form an oxo group, while the remaining R 7 , R 7a , R 8 , R 8a , R 9 , R 9a , R 10 , and R 10a are each independently selected from hydrogen or C 1 -C 3 alkyl; or one of R 10 , R 10a , R 7 , and R 7a together with one of R 8 , R 8a , R 9 and R 9a form an alkylene bridge, while the remaining R 10 , R 10a , R 7 , R 7a , R 8 , R 8a , R 9 , and R 9a are each independently selected from hydrogen or C 1 -C 3 alkyl; each R 12 is independently selected from hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl or aralkyl; and each R 13 is independently selected from hydrogen or C 1 -C 6 alkyl; as a stereoisomer, enantiomer or tautomer thereof, or a pharmaceutically acceptable salt thereof.