Patent ID: 7276504

Claim:
A method for the treatment of psoriasis, female infertility, diabetes, ophthalmic disorders, glaucoma, disorders of gastric motility, cystic fibrosis, premature labour, pulmonary hypertension, nitrate-induced tolerance, pre-eclampsia, alopecia, Parkinson's disease, pain, tinnitus or the renal syndrome comprising nasally administering to a subject in need thereof an effective amount of one or more 2-phenyl-substituted imidazotriazinones of formula (I) in which R 1 represents methyl or ethyl, R 2 represents ethyl or propyl, R 3 and R 4 are identical or different and represent a straight-chain or branched alkyl chain having up to 5 carbon atoms, which is optionally up to disubstituted identically or differently by hydroxyl or methoxy, or R 3 and R 4 together with the nitrogen atom form a piperidinyl ring, morpholinyl ring, thiomorpholinyl ring or a radical of the formula in which R 5 denotes hydrogen, formyl, acyl or alkoxycarbonyl in each case having up to 3 carbon atoms, or denotes straight-chain or branched alkyl having up to 3 carbon atoms, which is optionally mono- to disubstituted, identically or differently, by hydroxyl, carboxyl, straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 3 carbon atoms or by groups of the formula -(D) a -NR 6 R 7 or —P(O)(OR 8 )(OR 9 ), in which a denotes a number 0 or 1, D denotes a group of the formula —CO, R 6 and R 7 are identical or different and denote hydrogen or methyl, R 8 and R 9 are identical or different and denote hydrogen, methyl or ethyl, or R 5 denotes cyclopentyl, and the heterocycles mentioned under R 3 and R 4 , formed together with the nitrogen atom, are optionally mono- to disubstituted, identically or differently, optionally also geminally, by hydroxyl, formyl, carboxyl, acyl or alkoxycarbonyl in each case having up to 3 carbon atoms or groups of the formula —P(O)(OR 10 )(OR 11 ) or —(CO) b NR 12 R 13 , in which R 10 and R 11 are identical or different and denote hydrogen, methyl or ethyl, b denotes a number 0 or 1, and R 12 and R 13 are identical or different and denote hydrogen or methyl or the heterocycles mentioned under R 3 and R 4 , formed together with the nitrogen atom, are optionally substituted by straight-chain or branched alkyl having up to 3 carbon atoms, which is optionally mono- to disubstituted, identically or differently, by hydroxyl, carboxyl or by a radical of the formula P(O)OR 14 OR 15 , in which R 14 and R 15 are identical or different and denote hydrogen, methyl or ethyl, or the heterocycles mentioned under R3 and R4, formed together with the nitrogen atom, are optionally substituted by piperidinyl or pyrrolidinyl linked via N, and R 16 represents ethoxy or propoxy, or a salt, hydrate or solvate thereof.