Patent ID: 7838306

Claim:
An adsorbent for whole blood in the form of essentially spherical nonaggregated particles comprising: having pore sizes configured to allow configured to separate low density lipoproteins, immunoglobulins, fibrins, fibrinogens, immune complexes, fibronectins, or superantigens from whole blood to enter the pores, said porous carrier material having: an average pore size of 0.3 μm to ≦1.5 μm, whereby a maximum of about 50% of the pore volume of the organic porous carrier material is present in the form of pores having a pore size of >1.5 μm, an outer surface of the porous carrier material having at least one outer surface modification that does not interact with blood cells, and an inner surface of the porous carrier material having at least one inner surface modification that interacts with substances contained in blood, wherein the at least one outer surface modification is different from the at least one inner surface modification, wherein the porous carrier material has modifiable binding sites on its outer and inner surfaces, wherein at least one outer surface modification is by covalent bonding of at least one first functional group to the binding sites on the outer surface, wherein the at least one first functional group is at least one of poly(carboxylic acid), albumin, heparin, heparan sulfate and/or polymyxin, wherein the at least one inner surface modification is by covalent bonding of at least one second functional group to the binding sites on the inner surface, and wherein the at least one second functional group is selected from the group consisting of the complement factor C1q, peptides, antibodies and antigens.