Patent ID: 7723373

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which: n represents 1 or 2; R 1 is one or more substituents independently selected from halogen, CN, nitro, SO 2 R 4 , OR 4 , SR 4 , SOR 4 , SO 2 NR 5 R 6 , CONR 5 R 6 , NR 5 R 6 , NR 9 SO 2 R 4 , NR 9 CO 2 R 4 , NR 9 COR 4 , aryl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 1-6 alkyl, the latter five groups being optionally substituted by one or more substituents independently selected from halogen, OR 7 and NR 8 R 9 , NR 8 R 9 , S(O) x R 7 where x is 0, 1 or 2; R 2 is hydrogen, halogen, CN, SO 2 R 4 or CONR 5 R 6 , COR 4 or C 1-7 alkyl, the latter group being optionally substituted by one or more substituents independently selected from halogen atoms, OR 8 and NR 5 R 6 , S(O) x R 7 where x is 0, 1 or 2; R 3 is aryl or a 5-6 membered aromatic ring containing one or more heteroatoms selected from N, S and O, each of which is optionally substituted by one or more substituents independently selected from halogen, CN, nitro, SO 2 R 4 , OH, OR 4 , SR 4 , SOR 4 , SO 2 NR 5 R 6 , CONR 5 R 6 , NR 5 R 6 , NR 9 SO 2 R 4 , NR 9 CO 2 R 4 , NR 9 COR 4 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkyl, the latter three groups being optionally substituted by one or more substituents independently selected from halogen atoms, OR 7 and NR 8 R 9 , S(O) x R 7 where x is 0, 1 or 2; R 4 represents aryl, heteroaryl, or C 1 -C 6 alkyl, all of which are optionally substituted by one or more substituents independently selected from halogen atoms, aryl, heteroaryl, OR 10 and NR 11 R 12 S(O) x R 13 (where x=0, 1 or 2), CONR 14 R 15 , NR 14 COR 15 , SO 2 NR 14 R 15 , NR 14 SO 2 R 15 , CN, nitro; R 5 and R 6 independently represent a hydrogen atom, a C 1 -C 6 alkyl group,or an aryl group, the latter two of which may be optionally substituted by one or more substituents independently selected from halogen atoms, aryl, OR 13 and NR 14 R 15 , CONR 14 R 15 , NR 14 COR 15 , SO 2 NR 14 R 15 , NR 14 SO 2 R 15 , CN, nitro; or R 5 and R 6 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocylic ring optionally containing one or more atoms selected from O, S(O) x where x is 0, 1 or 2, NR 16 , and the ring itself is optionally substituted by C 1 -C 3 alkyl; R 7 and R 13 independently represent a C 1 -C 6 alkyl group, or an aryl or group all of which are optionally substituted by halogen atoms; R 8 represents a hydrogen atom, C(O)R 9 , C 1 -C 6 alkyl (optionally substituted by halogen atoms, or an aryl group, which also is optionally substituted by one or more fluorine atoms); or an aryl group, which is optionally substituted by one or more halogen atoms; each of R 9 , R 10 , R 11 , R 12 , R 14 , R 15 , independently represents a hydrogen atom, C 1 -C 6 alkyl, or an aryl group (all of which may be optionally substituted by one or more halogen atoms); and R 16 is hydrogen, C 1-4 alkyl, —C(O)C 1 -C 4 alkyl, C(O)YC 1 -C 4 alkyl, Y is O or NR 7 .