Patent ID: 7345164

Claim:
A method of making a 5′-acyloxynucleoside compound represented by the formula [A] wherein R 1 is an acyl group, and R 4 is wherein X is a hydrogen atom, a halogen atom, an amino group, an alkyl group, an aralkyl group, a substituted amino group or a hydroxyl group, and Y is a hydrogen atom, a halogen atom, an alkyl group, an aralkyl group or an aryl group, which comprises contacting a 2′,3′,5′-triacyloxynucleoside compound represented by the formula [I] wherein R 1 is as defined above, R 2 and R 3 are the same or different and each is independently an acyl group, in an alcohol represented by the formula [II] wherein R 5 is a hydrogen atom, an alkoxy group, an aryloxy group or an aryloxy group substituted with a halogen atom, with a base selected from the group consisting of alkali metal hydroxide, alkali metal alkoxide and alkali metal carbonate.