Patent ID: 8313521

Claim:
A method of delivering a bioactive material to a body vessel comprising the steps of: providing an expandable medical device sized and shaped for introduction into a vascular system of a patient, the expandable medical device having a vessel surface and a lumen surface and a coating on the vessel surface, the coating comprising a bioactive layer consisting essentially of paclitaxel or a derivative thereof, the bioactive layer being positioned between the vessel surface of the expandable medical device and a second layer, the second layer consisting essentially of a biodegradable polymer, wherein the second layer is free of a biostable polymer, wherein the second layer provides for controlled release of the paclitaxel or a derivative thereof and is free of bioactive material when deposited, the second coating layer positioned over the bioactive layer; inserting the expandable medical device into a body vessel using a catheter; and deploying the expandable medical device within the body vessel by placing the expandable medical device in contact with at least a portion of the body vessel, whereby the paclitaxel or derivative thereof is delivered to the body vessel.