Patent ID: 8044041

Claim:
A compound of formula III: wherein X is hydrogen, halogen, alkyl, aryl, heteroaryl, cyano or alkoxy; R′ is hydrogen, alkyl, —C(O)R x , —SO 2 R x or —P(O)(OR x ) 2 , where R x is hydrogen or alkyl; R 11 and R 12 are each independently hydrogen, halogen, hydroxy, cyano, amino, alkyl, alkenyl, alkynyl, heterocyclyl, alkoxy, alkythio, arylthio, -alkylene-NR a R b , C(O)R a , —C(O)NR a R b , -alkylene-C(O)NR a R b , —C(O)OR a , —C(S)NR a R b , —C(S)R a , —C(O)SR a , NO 2 , NH 2 , —NR a C(O)R b , —NR a R b , —NR a OR b , —NR a C(S)R b , —NR a C(O)NR b R c , —NR a C(S)NR b R c , —NR a (COOR b ), —NR a S(O) 2 NR b R c , —NR a S(O)R b , —NR a S(O) 2 R b , —OR a , —OC(O)R a , —ONR a R b , —OC(O)NR a R b , —SR a , —S(O) 2 R a , or —S(O) 2 NR a R b , wherein R a , R b and R c are each independently hydrogen, hydroxy, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, alkylaryl, haloaryl, heteroaryl, alkylheteroaryl, alkylheterocyclyl, alkoxy, alkythio, arylthio, or alkoxycarbonyl, wherein, if present, an aryl, alkylaryl, heteroaryl, alkylheteroaryl, heterocyclyl, or alkylheterocycyl may be substituted, in one or more positions with a substituent or a combination of substituents selected from halogen, hydroxy, cyano, nitro, amino, carboxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, alkylthio, —C(O)NR d -alkylheterocyclyl (in which R d is H or alkyl), O-alkylheterocyclyl, alkylheterocyclyl, aryl, heteroaryl, heterocyclyl, aryloxy, alkylamino, dialkylamino, aminoalkyl, -alkylene-O-alkyl, —NR e C(O)R f , —NR e (alkylene-NR e R f ), —NR e (alkylheterocyclyl), and —O-alkylene-NR e R f (in which R e and R f are independently hydrogen or alkyl; wherein at least one of R 11 or R 12 is -alkylene-C(O)NR a R b , -alkylene-NR a R b , —C(O)NR a R b , —NR a C(O)R b or —NR a R b ; and pharmaceutically acceptable salts thereof, provided that said compound is not: N-(3,4-dihydro-4-oxo-6-phthalazinyl)-2-methyl-2-propenamide, N-(1,2-dihydro-1-oxo-6-phthalazinyl)-2-methyl-2-propenamide, 7-(cyclohexylamino)-6-(phenylamino)-1(2H)-phthalazinone, 6,7-bis(phenylamino)-1(2H)-phthalazinone, 6-amino-7-chloro-1(2H)-phthalazinone, or a pharmaceutically acceptable salt thereof.