Patent ID: 6905707

Claim:
A controlled release oral dosage formulation, comprising: about 50-70% arginine α-ketoglutarate; and an excipient material comprising the remainder of the formulation; wherein excipient is chosen from microcrystalline cellulose, hydroxypropylmethyl cellulose, ethylcellulose, cellulose acetate butyrate, cellulose acetate phthalate, polyvinyl acetate phthalate, hydroxypropylmethyl cellulose phthalate, polyethylene oxide, polyvinylpyrrolidone, polyethylene glycol, zein, poly-DL-lactide-co-glycolide, dicalcium phosphate, calcium sulfate, and mixture thereof; wherein the formulation is characterized by releasing the arginine α-ketoglutarate in a manner so as to increase a period of time over which a therapeutic level of arginine α-ketoglutarate is maintained as compared to a quick release formulation.