Patent ID: 7368467

Claim:
A compound of formula (I) or pharmaceutical salt thereof wherein, Ar 1 is cycloalkyl, aryl, heterocyclyl or heteroaryl, each of which may be optionally substituted with one or more substituents selected from the group consisting of H, halogen, amino, hydroxy, cyano, nitro, carboxylate, alkyl, alkenyl, alkynyl, cycloalkyl, cyclohexyl, alkoxy, mono and di-alkyl amino, phenyl, carboxamide, haloalkyl, haloalkoxy, and alkanoyl; R 1 is Ar 2 or lower alkyl optionally substituted with Ar 2 ; Ar 2 is independently selected from cycloalkyl, aryl, heterocyclyl or heteroaryl, each of which may be optionally substituted with one or more substituents selected from the group consisting of H, halogen, amino, hydroxy, cyano, nitro, carboxylate, alkyl, alkenyl, alkynyl, cycloalkyl, cyclohexyl, alkoxy, mono and di-alkyl amino, phenyl, carboxamide, haloalkyl, haloalkoxy, and alkanoyl; q is 0, 1 or 2; each R 2 is independently selected from (CH 2 ) m CO 2 R 3 , (CH 2 ) m COAr 3 , (CH 2 ) m CONR 3 R 4 , (CH 2 ) m Ar 3 , (CH 2 ) 3 Ar 3 , (CH 2 ) n NR 3 R 4 or (CH 2 ) n OR 4 ; each R 3 is independently selected from H, or lower alkyl; each R 4 is independently selected from H, lower alkyl or (CH 2 ) p Ar 3 ; each Ar 3 is cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents, with the proviso that Ar 3 is not piperidinyl, tetrahydroquinolinyl or tetrahydroisoquinolinyl; each m is 1 or 2; each n is 2 or 3; each p is 0 or 1; each substituent for Ar 1 , Ar 2 and Ar 3 is independently selected from halogen, CN, NO 2 , OR 5 , SR 5 , S(O) 2 OR 5 , NR 5 R 6 , cycloalkyl, C 1 -C 2 perfluoroalkyl, C 1 -C 2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR 5 , C(O)NR 5 R 6 , OC(O)NR 5 R 6 , NR 5 C(O)NR 5 R 6 , C(NR 6 )NR 5 R 6 , NR 5 C(NR 6 )NR 5 R 6 , S(O) 2 NR 5 R 6 , R 7 , C(O)R 7 , NR 5 C(O)R 7 , S(O)R 7 , or S(O) 2 R 7 ; each R 5 is independently selected from hydrogen or lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino or C 3 -C 6 cycloalkyl; each R 6 is independently selected from hydrogen, (CH 2 ) p Ar 4 , or lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino or C 3 -C 6 cycloalkyl; each R 7 is independently selected from (CH 2 ) p Ar 4 or lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino or C 3 -C 6 cycloalkyl; and 0 each Ar 4 is independently selected from C 3 -C 6 cycloalkyl, aryl or heteroaryl, each optionally substituted with one to three substituents independently selected from halogen, OH, C 1 -C 4 alkoxy, NH 2 , C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino or 1,2-methylenedioxy.