Patent ID: 7687071

Claim:
A process for preparing a nano-particulate preparation of a pharmaceutical or cosmetic active ingredient with a core/shell structure, in which an X-ray amorphous active ingredient is present in the core together with one or more copolymers of acrylates, methacrylates, methacrylic acid or acrylic acid, and the shell consists of a stabilizing coating matrix, the process comprising mixing an active ingredient/polymer solution or precipitate with an aqueous solution of a polymeric coating material continuously in a mixing chamber by spraying the two components as a compact jet into a mixing chamber, wherein said polymeric coating material is selected from the group consisting of gelatin, chitosan, alginates, casein, caseinates, and homopolymers of acrylic acid, wherein the particle size of the core/shell structure is in the range of 0.05 to 0.9 μm, and wherein the core of the preparation has at least two separate phases.