Patent ID: 8349120

Claim:
A method of making a multi-layer patch with registration of multiple layers enclosed in a blister of sheet and film, comprising: a. placing molecules of a drug into a plurality of locations on a sheet to form a plurality of drug spots each separated from the other by at least one space of uncovered sheet; b. placing molecules of a base material in contact with each drug spot and entirely covering each drug spot to form a plurality of base spots each separated from the other by at least one space of uncovered sheet; c. molecules of a second layer in contact with each base placing spot and covering substantially all of each base spot to make a multi-layer spot; d. heat sealing a layer of film to the sheet covering the plurality of multi-layer spots to make a sandwich of sheet and film with the film heat sealed to the sheet in the uncovered spaces between multi-layer spots and enclosing each multi-layer spot in a blister of sheet and film containing only one multi-layer spot; and e. cutting the sandwich to form a plurality of cards, each card containing one or more blisters, each blister containing one multi-layer spot.