Patent ID: RE42412

Claim:
A method for treating a disease state by stimulating the motility of the gastrointestinal system, and wherein said disease state is selected from the group consisting of gastroesophageal reflux disease, dyspepsia, gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction, wherein said method comprises administering, to an individual in need of such a treatment, a compound, or an analog or salt thereof, wherein said compound has the following structure: wherein: R 1 is H, C 1-4 alkyl, OH, OC 1-4 alkyl, —COOH, —COOC 1-4 alkyl, —O(C═O)OC 1-4 alkyl, —O(C═O)C 1-4 alkyl, or —C 1-4 alkylNR 7 R 8 where R 7 and R 8 are, independently, H or C 1-4 alkyl; R 2 is H, C 1-4 alkyl, —OC 1-4 alkyl, —COOH, or —(C═O)OC 1-4 alkyl; X is O or N; R 3 is H or C 1-3 alkyl (if X is an oxygen atom, then R 3 does not exist); R 4 , R 5 , and R 6 are each, independently, selected from the group consisting of hydrogen, C 1-4 alkyl, —OC 1-4 alkyl, halogen atom, hydroxy, cyano, nitro, amino, mono- and di(lower alkyl)amino, aminocarbonyl, arylcarbonylamino, alkylcarbonylamino, lower-alkyl carbonyl, lower-alkyl carbonyloxy, aminosulfonyl, lower-alkylsulfinyl, lower-alkylsulfonyl, lower-alkylthio and mercapto; and wherein L has the formula —C n H 2n X—C m H 2m —(CR 9 R 10 ) p —(C═O)O—Y, wherein n is an integer from 1 to 4 inclusive; X is —CH(OH)—, —NH—, —S—, —O—, or a direct bond; m is an integer from 0 to 4 inclusive; p is 0 or 1; R 9 and R 10 are, independently, H, C 1-4 alkyl, or R 9 R 10 are linked and together form a 5- or a 6-membered cycloalkyl ring; and Y is cycloalkyl optionally substituted by 1 or more heteroatoms selected from the group consisting of O; N; S; or aryl or heteroaryl optionally substituted by 1 or more halogen atoms, C 1-4 alkyl, C 1-4 alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, trifluoromethyl, —COOH, or —COOC 1-4 alkyl.