Patent ID: 7399748

Claim:
A method of treating tumors in mammals comprising the intravenous infusion to a mammal suffering from a tumor of an α-halogen-acryloyl distamycin derivative as a single administration every three or four weeks in an amount of from 0.85 mg/m 2 to 20 mg/n 2 of body surface area, or weekly for three consecutive weeks every four or five weeks in an amount of from 0.3 mg/m 2/ week to 7 mg/m 2/ week, wherein said α-halogen-acryloyl distamycin denvative has the formula (I) wherein: R is a bromine or chlorine atom; or a pharmaceutically acceptable salt thereof; and an additional antitumor agent selected from the group consisting of cisplatin, CPT-11 and docetaxel as a combined preparation for simultaneous, separate or sequential use, whereby tumor growth in said mammal is inhibited.