Patent ID: 8092788

Claim:
A composition comprising a biologically active protein which is not insulin and a positively charged carrier comprising a positively charged polymeric backbone having attached thereto amino acid sequences selected from the group consisting of -(gly) n1 -(arg) n2 , (gly) p -RGRDDRRQRRR-(gly) q (SEQ ID NO. 2), (gly) p -YGRKKRRQRRR-(gly) q (SEQ ID NO. 3), (gly) p -RKKRRQRRR-(gly) q (SEQ ID NO. 4), and Antennapedia protein transduction domain (PTD), wherein the subscript n1 is an integer of from 0 to about 20, and the subscript n2 is independently an odd integer of from about 5 to about 25, wherein the subscripts p and q are each independently an integer of from 0 to 20; wherein the positively charged polymeric backbone is a polypeptide that promotes transdermal delivery of the biologically active protein; wherein said positively charged carrier is present in an effective amount for transdermal delivery of said biologically active protein, wherein the biologically active protein is not modified by covalent attachment to a negatively charged backbone; and wherein the positively charged carrier and the biologically active protein directly contact to form a non-covalent complex.