Patent ID: 7819855

Claim:
A method for delivery of an agent to a delivery site in a subject, the method comprising the steps of: (a) implanting at a delivery site in a subject at least a distal portion of a catheter comprising: an elongate body comprising a proximal end defining an inlet, and a distal end defining an outlet, the elongate body defining a passageway extending between the proximal and distal ends, and a modifying element operatively associated with the elongate body such that at least an inner wall of the modifying element is in fluid communication with the elongate body passageway; wherein flowable formulation introduced into the elongate body inlet moves through the elongate body passageway, contacts the modifying element inner wall, and exits the catheter; and (b) introducing a formulation comprising an agent into the inlet of the elongate body; wherein the introduced formulation containing said agent flows through the elongate body passageway whereby the agent contacts the modifying element and undergoes a physical or chemical change to provide a modified agent that is then released at the delivery site in the subject.