Patent ID: 8178661

Claim:
An isolated nucleic acid molecule selected from the group consisting of: a) a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of SEQ ID NO: 10, 12 or an entire complement thereof, wherein the nucleic acid molecule encodes a polypeptide which binds Bcl-10 and comprises a CARD domain; b) a nucleic acid molecule comprising a fragment of at least 75 consecutive nucleotides of the nucleotide sequence of SEQ ID NO: 10, 12 or an entire complement thereof; c) a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO: 11, wherein the polypeptide binds Bcl-10 and comprises a CARD domain; d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO: 11, wherein the fragment comprises the CARD domain of residues 6-112 of SEQ ID NO:11, wherein the fragment binds Bcl-10; and e) a nucleic acid molecule which encodes a variant of the amino acid sequence of SEQ ID NO: 11, wherein the nucleic acid molecule hybridizes to the entire SEQ ID NO: 10, 12 or entire complement thereof under conditions of incubation at 45° C. in 6.0×SSC followed by washing in 0.2×SSC/0.1% SDS at 65° C., wherein the variant binds Bcl-10 and comprises a CARD domain.