Patent ID: 8916593

Claim:
A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein R 1 is a thiazolyl, oxazolyl, imidazolyl, triazolyl or 1,2,4-thiadiazolyl wherein said thiazolyl, oxazolyl, imidazolyl, triazolyl and 1,2,4-thiadiazolyl are optionally substituted with one, two or three R 3 groups; X 1 is CH and X 2 is CH; X 3 is N or CH; R 2 is a triazolyl; each R 3 is independently selected from halogen, C 1 -C 6 alkyl, C 2 -C 4 alkenyl, —(CH 2 ) n CN, —(CH 2 ) n S(O) 2 CH 3 , —S(O) 2 NR 4 R 5 , —PO(CH 3 ) 2 , —(CR 4 R 5 ) n NR 4 R 5 , —(CR 4 R 5 ) n OR 4 , —OCH 2 (CR 4 R 5 ) n OR 4 , —(CR 4 R 5 ) n CO(CR 4 R 5 ) m NR 4 R 5 , —(CR 4 R 5 ) n CR 4 (OR 5 )(CR 4 R 5 )OR 5 , oxo, —O(4-6-membered heterocyclyl containing 1, 2 or 3 heteroatoms independently selected from O, N and S(O) p ), and 4-6-membered heterocyclyl containing 1, 2 or 3 heteroatoms independently selected from O, N and S(O) p ; wherein said C 1 -C 6 alkyl is optionally substituted with one or two hydroxy groups, and wherein each said 4-6-membered heterocyclyl is optionally substituted with one or more halogen, hydroxy, oxo, —(CR 4 R 5 ) n CO(CR 4 R 5 ) m NR 4 R 5 or C 1 -C 6 alkyl, or substituents on two ring atoms of said 4-6-membered heterocyclyl may optionally combine to form a 5- or 6-membered bridged ring that is either carbocyclic or heterocyclic containing one, two or three ring heteroatoms selected from N, O and S(O) p ; each R 4 or R 5 is independently H or C 1 -C 6 alkyl; each m is independently 0, 1, 2 or 3; each n is independently 0, 1, 2 or 3; and each p is independently 0, 1 or 2.