Patent ID: 8716283

Claim:
A method for inhibiting activity of a type III secretion system of a bacterium, comprising contacting a bacterium having a type III secretion system with an effective amount of at least one compound selected from the formula: and a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of: —O—(C1-C5)alkyl, —NH—(C1-C5)alkyl, —NH 2 , and —OH, and R2 is wherein: R3 and R4 are joined as a five- or six-member heterocyclic ring that may be further substituted at any one position with —CO—O—(C1-C5)alkyl or (C1-C5)alkyl, or R3 is —H or —(C1-C5)alkyl and R4 is selected from the group consisting of: —(C1-C5)alkyl, —(C3-C8)cycloalkyl, —(C1-C5)alkyl-O—(C1-C5)alkyl, —(C1-C5)alkyl-hydroxyl, -phenyl, and —(C1-C5)alkyl-phenyl, wherein the phenyl group may be independently substituted at one, two, or three positions with —(C1-C5)alkyl or -halogen, and R5 is selected from the group consisting of: —(C1-C5)alkyl, —(C3-C8)cycloalkyl, -phenyl, and —(C1-C5)alkyl-phenyl, wherein the phenyl group may be substituted at one, two, or three positions with a substituent independently selected from the group consisting of: —(C1-C5)alkyl, —O—(C1-C5)alkyl, -halogen, —NO 2 , —CF 3 , and —OCF 3 .