Patent ID: 8545814

Claim:
A system for determining the location of a biocompatible entity in the interior of an intact mammal, the system comprising an exogenous biocompatible entity that localizes at one or more specific sites within the interior of the mammal; a light generating moiety that is conjugated to the localized biocompatible entity, wherein the light generating moiety comprises a luciferase and a fluorescent moiety; a charge-coupled device (CCD) camera outside the mammal that detects, through intact skin, light emitted from the luciferase and the fluorescent moiety of the light generating moiety, wherein the light emitted from the light generating moiety is not quenched by endogenous oxygen; and an image processor attached to the CCD camera, wherein the image processor creates a two- or three-dimensional image from light emitted from the light-generating moiety, thereby showing the location of the biocompatible entity within the intact mammal.