Patent ID: 7105510

Claim:
A compound represented by formula I: wherein R 1 is selected from the group consisting of H, halogen, (C 1-4 )alkyl, O(C 1-6 )alkyl, and haloalkyl; R 2 is H or (C 1-4 )alkyl; R 3 is H or (C 1-4 )alkyl; R 4 is (C 1-4 )alkyl, (C 1-4 )alkyl(C 3-7 )cycloalkyl, or (C 3-7 )cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q is selected from the group consisting of: a) wherein one of E and G is C(O) and the other is NR 5 wherein R 5 is selected from the group consisting of H, hydroxy and (C 1-4 )alkyl unsubstituted or substituted with pyridinylmethyl, (pyridinyl-N-oxide)methyl or C(O)OR 6 wherein R 6 is H or (C 1-4 )alkyl; and each R 7 is independently H, Me or Et; or b) wherein E is NR 8 wherein R 8 is H, (C 1-4 )alkyl unsubstituted or substituted with C(O)OR 9 wherein R 9 is H or (C 1-4 )alkyl; or c) wherein D and G are NR 10 wherein each R 10 is independently H or (C 1-4 )alkyl unsubstituted or substituted with C(O)OR 11 wherein R 11 is H or (C 1-4 )alkyl; or d) wherein one of L, M, Y and Z is NR 12 wherein R 12 is H, (C 1-4 )alkyl unsubstituted or substituted with C(O)OR 12x wherein R 12x is H or (C 1-4 )alkyl; one of the remaining positions of L, M, Y and Z adjoining the NR 12 is C(O); and the remaining two positions are each CR 13 R 13 wherein each R 13 is independently H, Me or Et; or e) wherein three adjoining positions of L, M, Y and Z (namely L-M-Y or M-Y-Z) represent NR 14 —C(O)—O— or —NR 15 —C(O)—NR 16 — wherein R 14 , R 15 and R 16 each represents H or (C 1-4 )alkyl unsubstituted or substituted with C(O)OR 17 wherein R 17 is H or (C 1-4 )alkyl; and the remaining position of L, or Z is CR 18 R 18 wherein each R 18 is H, Me or Et; or a pharmaceutically acceptable salt, thereof.