Patent ID: 8546415

Claim:
A method of treating a dopamine mediated disease state comprising administering to an individual in need thereof an effective amount of a composition comprising at least one nicotine antagonist having the formula wherein: Rings 1 and 2 are pyridinium; R 2 , R 3 , R 4 , R 5 , R 6 are each independently selected from hydrogen; alkyl; and substituted alkyl; R 1 is selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, alkoxy, alkylamine, thioalkyl; and X is selected from Cl, Br, I, HSO 4 , ½SO 2 , CH 3 SO 3 , p-TsO, CF 3 SO 3 and any ion that completes the salt form of the nicotine antagonist; and enantomers, diastereomers and racemic mixes thereof, wherein the nicotine antagonist binds to nAChR and inhibits release of dopamine.