Patent ID: 7723336

Claim:
A compound according to formula (I), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt, thereof, wherein: E is C; F is N; X is NR 4 R 5 ; Z is CR 3 ; Y is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogen, nitro, cyano, SR 8 , S(O) p R 8 , OR 8 , NR 6 R 7 , CO 2 R 8 , C(═O)R 8 , O—C(═O)R 8 , C(═O)NR 8 R 9 , cycloalkyl, cycloalkenyl, cycloalkynyl, heterocyclo, aryl, and heteroaryl, provided that if Y is hydrogen then R 4 is phenyl substituted with a carboxamido group; R 1 and R 2 are independently selected from (i) hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogen, nitro, cyano, SR 10 , OR 10 , NR 10 R 11 , NR 10 C(═O)R 11 , CO 2 R 10 , C(═O)R 10 , —O—C(═O)R 10 , C(═O)NR 10 R 11 , cycloalkyl, heterocyclo, aryl, and heteroaryl; or (ii) R 1 is taken together with R 2 and the ring atoms to which they are attached to form a fused 5-, 6-, or 7-membered cycloalkyl, aryl, heteroaryl, or cycloheteroalkyl; R 3 is selected from hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, nitro, cyano, SR 13 , OR 13 , NR 13 R 14 , NR 13 C(═O)R 14 , CO 2 R 13 , C(═O)R 13 , —O—C(═O)R 13 , —C(═O)NR 13 R 14 , cycloalkyl, heterocyclo, aryl, and heteroaryl; R 4 , R 5 , R 6 , and R 7 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, OR 15 , SR 15 , C(═O)R 15 , CO 2 R 15 , C(═O)NR 15 R 16 , C(W)OR 16 , S(O) p R 17 , SO 2 NR 15 R 16 , substituted or unsubstituted cycloalkyl, heterocyclo, aryl, and heteroaryl; or (ii) R 4 is taken together with R 5 and the nitrogen atom to which they are both attached and/or R 6 is taken together with R 7 and the nitrogen atom to which they are both attached to form a substituted or unsubstituted heteroaryl or heterocyclo; R 8 , R 9 , R 10 , R 11 , R 13 , R 14 , R 15 , and R 16 at each occurrence are independently selected from (i) hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, substituted or unsubstituted cycloalkyl, aryl, heteroaryl, and heterocyclo; or (ii) together with the nitrogen atom to which they are attached, R 8 is taken together with R 9 , and/or R 10 is taken together with R 11 , and/or R 13 is taken together with R 14 , and/or R 15 is taken together with R 16 to form a substituted or unsubstituted heteroaryl or heterocyclo; R 17 at each occurrence is independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; W at each occurrence is O, S, N, CN, or NH; and p is 1 or 2, with the following provisos: (1) if X is NH(Me), N(Me) 2 , NH(unsubstituted phenyl), or NH 2 , then Y is other than hydrogen or halogen; and (2) if R 1 is methyl, then X is not N(ethyl) 2 .