Patent ID: 7189856

Claim:
A non-peptide, somatostatin receptor ligand represented by Formula IA: wherein A and B independently are O or (H, H); R 1 is a group of formula wherein the R 2 groups are, independently, hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or alkylaryl; X is aryloxy, cyano, —CO 2 R b , or —C(O)N(R c ) 2 wherein R h is H, alkyl or alkylaryl and wherein the R c groups are, independently, hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylaryl, heterocyloalkyl or are optionally joined to form a six membered ring; Q is an alkyl spacer group optionally interrupted by oxygen, sulfur or nitrogen atoms and optionally substituted by hydroxy, alkoxy, alkyl, or aryl; Z 4 , Z 2 , and Z 3 are independently, carbon, oxygen, sulfur, or nitrogen optionally substituted with an alkyl; n is an integer from 0 to 2; and Y is either hydrogen, an alkyl, heterocyloalkyl, or CH 2 N(R a ) 2 ; R 2 is CH(R d )—Ar or —S 2 —Ar wherein R d is alkyl, aryl, cyano, —CO 2 R b , or —C(O)N(R c ) 2 ; Ar is phenyl or naphthyl optionally and independently, mono- or di- substituted by hydroxy, cyano, halogen, alkyl, alkoxy, —N(R a ) 2 , alkyllhio, alkylsulfonyl, arylsulfonyl, nitro, —S(O) 2 N(R c ) 2 , trifluoromethyl, —C 2 N(R a ) 2 , —CO 2 R b , —C(O)N(R c ) 2 , or an aromatic group of formula wherein A is CH 2 , O, NH, S or CO and the R c groups, independently, are hydrogen, alkyl, alkoxy, trifluoromethyl, cyano, nitro, amino, halogen, hydroxy; R 3 is selected from hydrogen, alkyl, aryl, alkylaryl or heteroaryl; and R 4 is a group of formula: wherein Z 1 , Z 2 , and Z 3 are, independently, carbon, oxygen, sulfur or nitrogen optionally substituted with an alkyl; R f is hydrogen, alkyl or an aryl group; and R g is hydrogen, halogen, cyano, trifluoromethyl, aryl, alkyl or alkoxy.