Patent ID: 7129238

Claim:
A compound of the formula (I) wherein R 1 is hydrogen, OH, NH 2 , lower-alkoxy-carbonyl, aryl-lower-alkoxy-carbonyl, aryloxy-carbonyl, lower-alkyl-carbonyl, aryl-carbonyl, or halogen substituted lower-alkoxy-carbonyl; R 2 , R 3 and R 4 independently from each other are selected from the group consisting of hydrogen, halogen, hydroxy, carboxy-lower-alkyl-NH, carbamoyl-lower-alkyl-NH, lower-alkoxy-carbonyl-lower-alkyl-NH, hydroxy-cycloalkyl-oxy, dihydroxy-cycloalkyl-oxy, aryl, aryloxy, aryl-NH, aryl-lower-alkyl-NH, aryl-lower-alkyl-SO 2 —NH, aryl-lower-alkoxy-carbonyl-NH, aryl-lower-alkyl-NH-carbonyl-NH, heteroaryloxy, heteroaryl-lower-alkyl-NH, lower-alkoxy, and lower-alkoxy substituted with hydroxy, carboxy, carbamoyl, carbamimidoyl, CF 3 , aryl, heteroaryl, lower-alkyl-carbamoyl, lower-alkoxy-carbonyl, aryl-carbamoyl, lower-alkoxy-lower-alkyl-carbamoyl, heterocyclyl-lower-alkyl-carbamoyl, or N(lower-alkyl) 2 -lower-alkyl-carbamoyl; R 5 is lower-alkyl or cycloalkyl, or, if X is O or NR 12 , R 5 is lower alkyl, cycloalkyl or hydrogen; R 6 is hydrogen, lower-alkyl, or fluoro-lower-alkyl; Y is N or C—R 11 ; R 7 , R 8 , R 9 , R 10 and R 11 independently from each other are selected from the group consisting of hydrogen, hydroxy, halogen, amino, lower-alkyl-amino, di-lower-alkyl-amino, lower-alkyl-carbonyl-amino, NO 2 , fluoro-lower-alkyl, lower-alkoxy, hydroxy-lower-alkoxy, fluoro-lower-alkoxy, lower-alkinyl, hydroxy-lower-alkinyl, aryl, aryl-lower-alkoxy, aryloxy, aryloxy-lower-alkoxy, heterocyclyl, heterocyclyloxy, lower-alkoxy-carbonyl-lower-alkoxy, carbamoyl-lower-alkoxy, carboxy-lower-alkoxy, cycloalkyloxy, heteroaryl, amino-lower-alkoxy, lower-alkyl-amino-lower-alkoxy, and di-lower-alkyl-amino-lower-alkoxy, lower-alkyl-carbonyl-amino-lower-alkyl, HO—N═CH, HCO, fluoro-lower-alkyl-SO 2 —O, (lower-alkoxy) 2-4 , CH(lower-alkoxy) 2 , hydroxy-chloro-lower-alkoxy, aryl-lower-alkoxy-lower-alkoxy, aryl-NH, aryl-NH-lower-alkyl, aryl-lower-alkyl-carbonyl-NH, heterocyclyl-lower-alkyl, heterocyclyl-carbonyl, heterocyclyl-lower-alkoxy, lower-alkyl-carbamoyl, fluoro-lower-alkyl-carbamoyl, cycloalkyl-carbamoyl, cycloalkyl-lower-alkyl-carbamoyl, di-lower-alkyl-carbamoyl, lower-alkoxy-lower-alkyl-carbamoyl, di-lower-alkyl-carbamoyl-lower-alkoxy, heteroaryloxy, heteroaryl-lower-alkoxy, amino-lower-alkyl, lower-alkyl, hydroxy-lower-alkyl, cycloalkyl, cycloalkyl-lower-alkoxy, and cycloalkyl-lower-alkoxy substituted with lower-alkyl; or R 8 and R 9 or R 8 and R 7 are bound to each other to form a ring together with the carbon atoms to which they are attached and R 8 and R 9 together or R 8 and R 7 together are —O—CH 2 —O—, —O—CH 2 —CO—NH—, —O—CH 2 —CH 2 —CH 2 —, —CH═CH—CH═CH—, or —CH═CH—CH═CH— substituted with lower-alkyl or lower-alkoxy, and R 10 , R 11 and R 7 or R 9 respectively are as defined above; X is O, S, NR 12 , or SO 2 ; R 12 is hydrogen, lower-alkyl, or lower-alkyl-carbonyl; or a pharmaceutically acceptable salt thereof.