Patent ID: 7709468

Claim:
A compound of formula (I), or pharmaceutically acceptable salts thereof wherein Z is an optionally substituted aryl or heteroaryl; X and Y are each independently N, CR 4 or N-oxide, provided that X and Y cannot both be CR 4 or X and Y cannot both be N-oxide; A is N, CR 4 or N-oxide; R 1 and R 10 is each independently H, OH, F, Cl, Br, I, CF 3 , CN, OCF 3 , nitro or amino; or R 1 and R 10 is each independently selected from the optionally substituted group consisting of aryloxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkyl-O—(C 1 -C 6 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, heterocyclyl, aryl, —CO 2 (C 1 -C 6 )alkyl, —CONR 5 R 6 , —SO 2 NR 5 R 6 , SO (n) alkyl, —NHCOR 5 , —NHSO 2 R 5 , —N((C 1 -C 4 )alkyl)COR 5 , —N((C 1 -C 4 )alkyl)SO 2 R 5 , NR 5 R 6 , O(C 1 -C 6 )alkyl-R 7 and (C 1 -C 6 )alkylR 7 ; Q is N(R 2 ), O, S or is a bond; L is a bond, (C 1 -C 6 )alkyl, C(O), —C(O)—O—, —C(O)—N(H)—, SO or SO 2 ; R 3 selected from the group consisting of H, —C(O)NR 5 R 6 , —NR 2 C(O)R 5 , —NR 2 C(O) 2 R 5 , C(O)OR 2 , R 3 is selected from the optionally substituted group consisting of aryl, heterocyclyl, heterocyclylalkylaryl, 1,4-dioxaspiro[4.5]decane, azabicyclo[3.2.1]octane and azabicyclo[2.2.2]octane; or R 3 is selected from the optionally substituted group consisting of (C 1 -C 9 )alkyl and (C 3 -C 8 )cycloalkyl; wherein the (C 1 -C 9 )alkyl and (C 3 -C 8 )cycloalkyl are optionally substituted with one or more (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-OR 2 , OR 2 or N(R 2 ) 2 ; R 2 for each occurrence is independently H or (C 1 -C 4 )alkyl; R 4 is H, OH, F, Cl, Br, I, CF 3 , CN, OCF 3 , nitro or amino; or R 4 is selected from optionally substituted group consisting of (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, aryloxy, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, heterocyclyl, aryl, —CONR 5 R 6 , —SO 2 NR 5 R 6 , —SO (n) alkyl, —NR 2 COR 5 , —NR 2 SO 2 R 5 , —NR 5 R 6 , —CO 2 (C 1 -C 6 )alkyl, —N((C 1 -C 4 )alkyl)CO—R 5 , or —N((C 1 -C 4 )alkyl) SO 2 —R 5 ; R 5 and R 6 are each independently H, or are independently selected from the optionally substituted group consisting of (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 2 -C 6 )hydroxyalkyl, (C 2 -C 6 )aminoalkyl, (C 3 -C 8 )cycloalkyl, aryl and heterocyclyl; or R 5 and R 6 are taken together with the N atom to which they are attached to form an optionally substituted heteroaryl or heterocyclyl ring; R 7 is CF 3 , NR 5 R 6 , OH, (C 1 -C 6 )alkoxy or optionally substituted (C 3 -C 8 )cycloalkyl; m is 0, 1 or 2; n is 0, 1, 2; and p is 1,2, 3 or 4.