Patent ID: 8841323

Claim:
A compound according to the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, or a stereochemically isomeric form thereof, wherein V 1 is selected from the group consisting of an unsubstituted bivalent saturated, straight or branched hydrocarbon radical having from 1 to 6 carbon atoms; M 1 is selected from the group consisting of hydrogen; cycloC 3-7 alkyl; phenyl optionally substituted with OCF 3 or F; phenyloxy-; and tetrahydropyranyl; L is selected from the group consisting of a covalent bond; —O—; —OCH 2 —; NR 7 —; wherein R 7 , is selected from the group consisting of hydrogen and unsubstituted C 1-3 alkyl; R 2 and R 3 are hydrogen; A is piperidinyl selected from the group consisting of wherein n is an integer equal to 0, 1, or 2; R 4 is, when present, at any of b, or c positions and is selected from the group consisting of C 1-6 -alkyl; C 1-6 -alkyloxy; C 1-6 -alkyloxycarbonyl-; polyhaloC 1-3 alkyl-; Het 3 ; Het 3 -C 1-6 -alkyl-; Het 3 -oxy-; Het 3 -oxy-C 1-6 -alkyl-; Het 3 -C 1-6 -alkyloxy; —NR a R b ; C 1-6 -alkyl-NR a R b ; wherein R a and R b are selected from the group consisting of hydrogen, C 1-6 -alkyl, and C 3-7 -cycloalkyl; and Het 3 is selected from the group consisting of pyridinyl; pyrimidinyl; pyridazinyl; pyrrolyl; indolyl; morpholinyl; oxadiazolyl; benzoxazolyl; benzofuranyl; indolinyl; 1,2,3,4-tetrahydro-isoquinolinyl; phthalazinyl; and benzo[1,3]dioxolyl wherein each radical is optionally substituted with 1 or 2 substituents, each independently selected from the group consisting of halo, C 1-6 alkyl, C 3-7 -cycloalkyl, polyhaloC 1-3 alkyl, cyano, mono(C 1-6 alkyl)amino, oxo, phenyl, morpholinyl, and C 1-3 alkyloxy.