Patent ID: 8920817

Claim:
A composition comprising a formulation of a pharmaceutically active agent, a volatile counterion and a non-volatile counterion, wherein said formulation has a pH, said biologically active agent has a positive charge at said formulation pH; wherein said volatile counterion comprises a weak acid having at least one pKa higher than about 2 and a melting point lower than about 50° C. or a boiling point lower than about 170° C.; wherein said non-volatile counterion comprises a strong acid having at least one pKa lower than about 2; wherein said pharmaceutically active peptide agent is present as uncharged species and as charged species and wherein said non-volatile counterion is present in an amount sufficient to achieve a molar ratio between said uncharged species and charged species of about 1 uncharged species to at least 100 charged species; wherein said formulation has increased pH stability and solubility when dried, and wherein said composition is applied to a transdermal delivery device having stratum corneum-piercing microprojections; wherein said composition achieves an increase in delivery of the pharmaceutically active agent compared to a composition comprising a formulation without said non-volatile counterion.