Patent ID: 8835602

Claim:
A compound of formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein Z is —NR 5 X is —CR a R b —; Y is —CR c R d —; R a , R c , R b , and R d are independently —H or a substituted or unsubstituted alkyl or aralkyl group; R 1 at each occurrence is independently —H or a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroaralkyl group; or, R 1 together with the carbon to which it is attached and the adjacent nitrogen, forms a substituted or unsubstituted pyrrolidine, oxazolidine, thiazolidine, imidazolidine, or piperidine ring; R 2 is —H or a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroaralkyl group; or R 2 and R 3 together with the atoms to which they are attached form a substituted or unsubstituted pyrrolidine, oxazolidine, thiazolidine, imidazolidine, or piperidine ring; R 3 is —H, PG 3 , or a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroaralkyl group; wherein PG 3 is a protecting group; or R 2 and R 3 together with the atoms to which they are attached form a substituted or unsubstituted pyrrolidine, oxazolidine, thiazolidine, imidazolidine, or piperidine ring; R 4 is —H, a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroaralkyl group, or a CHR 1 —NH—R 6 group; R 5 is a —H, a substituted or unsubstituted alkyl, aryl, aralkyl, heteroaryl or a heteroaralkyl group, or a —NH—CHR 1 —C(O)—R 7 group; R 6 is —H, a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroaralkyl group, C(O)R 10 , —C(O)OR 10 , —[C(O)—CHR 1 —NH] m —R 10 , —[C(O)—CHR 1 —NH] m —C(O)R 10 , or —[C(O)—CHR 1 —NH] m —C(O)R 10 ; R 7 is a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroaralkyl group, —OR 10 , NR 10 R 10 , or —[NH—CHR 10 —C(O)] m —; R 10 at each occurrence is independently —H or a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroaralkyl group; m at each occurrence is independently an integer from 1 to 20; and n is an integer from 1 to 20.