Patent ID: 7405038

Claim:
A composition comprising a baculovirus expression system for expressing a recombinant protein, including: a) a baculovirus that has a functional p35 gene, and is engineered to express a recombinant protein; b) a cultured Sf9 cell line that is susceptible to infection by said baculovirus, and is engineered by transfection with a first recombinant expression vector to express a recombinant polynucleotide that encodes AcNPV p35, wherein said recombinant polynucleotide is cloned into said first recombinant expression vector such that said recombinant polynucleotide is capable of being expressed in said cell line; c) said first recombinant expression vector being delivered into at least one cell of said cultured cell line; and d) said at least one cell being infected by said baculovirus; e) such that apoptosis is inhibited, when said engineered cell line is infected by said baculovirus that includes a functional p35 gene.