Patent ID: 6852492

Claim:
A method of sequencing nucleic acid molecules comprising: a) inserting multiple copies of a template nucleic acid molecule into a reaction chamber; b) synthesizing a complementary nucleic acid molecule from nucleotide precursors with a polymerase; c) monitoring the order of incorporation of nucleotide precursors into the complementary nucleic acid molecule by surface enhanced Raman scattering, surface enhanced resonance Raman scattering, stimulated Raman scattering, inverse Raman, stimulated gain Raman spectroscopy, hyper-Raman scattering or coherent anti-Stokes Raman scattering, wherein a tag molecule is attached to each nucleotide precursor; and d) determining the sequence of the template nucleic acid molecule from the order of incorporation of nucleotide precursors into complementary nucleic acid molecules.