Patent ID: 8685538

Claim:
A stable nanoparticle comprising: a compound; and a polymeric coating comprising alternating polymeric layers of oppositely charged polymers, the nanoparticle having a diameter of about 20 nm to about 100 nm; wherein the oppositely charged polymeric layers each independently consist of a polymer selected from the group consisting of acacia, acrylate gels, albumins, bovine serum albumin (BSA), human serum albumin (HSA), alginates, alginic acids, sodium alginate, cross-linked alginates, cellulose, carboxymethyl cellulose, cellulose derivatives, cellulose acetate, chondroitin sulfate, collagen, collagen derivatives, methylated collagen, succinylated collagen, cross-linked collagen, collagen-like proteins, chitosan, chitosan derivatives, methylpyrrolidone chitosan, dextran, dextran derivatives, dextran amine, dextran sulfate, carboxymethyl dextran, fibrin, gelatin, gelatine A, gelatin B, glycosaminoglycans, glycosoaminoglycan derivatives, graphite, glycolides, heparin, hyaluronic acid, cross-linked hyaluronic acid, keratin, lactides, myosin, nylon-2/nylon-6-copolyamides, poly casein, poly(acrylic acid), poly(alkylene succinates), poly(allylamine hydrochloride) (PAH), poly(allylamine), poly(butylene diglycolate), poly(cyanoacrylates), poly(aspartic acid), poly(d-aspartic acid), poly(l-aspartic acid), poly(dl-aspartic acid), polyglutamic acids, poly(d-glutamic acid), poly(l-glutamic acid), poly(dl-glutamic acid), polyarginine, polylysine, poly(dimethyldiallyammonim chloride), poly(dimethyldiallylamide ammonium chloride) (PDDA), poly(ethylenimine), poly(glutaric acid), poly(hydroxy butyrate) (PHB), poly(lactide-co-glycolide), poly(ortho ester), polyanhydride, polycaprolactone, polyglycolic acid (PGA), polydihydropyrans, polyethylene glycol, polyglycolide, polyhydroxyalkonates, polylactic acid (PLA), polyesters, polypeptides, polynucleotides, polysaccharides, polysaccharide derivatives, polyoxalates, polyoxanones, polyphosphazenes, polytetrafluoroethylene, polyurethanes, polyvinylalcohol, polyvinylpyrrolidone, protamine sulfate (PS), copolymer of poly(bis(p-carboxyphenoxy)propane)anhydride (PCPP) and sebacic acid, copolymer of polylactic acid and polyglycolic acid (PLGA), silicone rubbers, silk-like proteins, silk-elastin-like proteins, starch, derivatives of starch, hydroxyethyl starch, substantially pure carbon lattices and combinations and copolymers thereof; and wherein the nanoparticle does not contain a detergent or a surfactant.