Patent ID: 7262211

Claim:
A compound of the formula: wherein: (a)X is —S(O) 2 —; (b) R 1 is selected from the group consisting of: (1) alkyl of 1 to about 12 carbon atoms which is unsubstituted or substituted with 1 to 2 substituents selected from the group consisting of Y 1 and Y 2 , (2) alkyl of 1 to about 3 carbon atoms substituted with cycloalkyl of 3 to about 8 carbon atoms which is unsubstituted or mono-, di- or tri-substituted with 1 to 3 substituents selected from the group consisting of Y 1 , Y 2 , and/or Y 3 , (3) aryl of about 6 to about 14 carbon atoms which is unsubstituted or mono-, di- or tri-substituted with 1 to 3 substituents selected from the group consisting of Y 1 , Y 2 and Y 3 , (4) aralkyl of about 7 to about 15 carbon atoms which is unsubstituted or substituted on the alkyl chain with hydroxy or halogen and which is unsubstituted or mono-, di- or tri-substituted on the aryl ring with 1 to 3 substituents selected from the group consisting of Y 1 , Y 2 and Y 3 ; wherein each Y 1 , Y 2 , and Y 3 is independently selected and is selected from the group consisting of halogen, cyano, nitro, tetrazolyl, guanidino, amidino, methylguanidino, —CF 3 , —CF 2 CF 3 , —CH(CF 3 ) 2 , —C(OH)(CF 3 ) 2 , —OCF 3 , —OCF 2 H, —OCF 2 CF 3 , —OC(O)NH 2 , —OC(O)NHZ 1 , —OC(O)NZ 1 Z 2 , —NHC(O)Z 1 , —NHC(O)NH 2 , —NHC(O)NZ 1 , —NHC(O)NZ 1 Z 2 , —C(O)OH, —C(O)OZ 1 , —C(O)NH 2 , —C(O)NHZ 1 , —C(O)NZ 1 Z 2 , —P(O) 3 H 2 , —P(O) 3 (Z 1 ) 2 , —S(O) 3 H, —S(O) m Z 1 , —Z 1 , —OZ 1 , —OH, —NH 2 , —NHZ 1 , —NZ 1 Z 2 , —C(═NH)NH 2 , —C(═NOH)NH 2 , —N-morpholino, and —S(O) m (CF 2 ) q CF 3 , wherein m is 0, 1 or 2, q is an integer from 0 to 5, and Z 1 and Z 2 are independently selected from the group consisting of alkyl of 1 to about 12 carbon atoms, aryl of about 6 to about 14 carbon atoms, aralkyl of about 7 to about 15 carbon atoms, (6) J is —C(R 6a )(R 6b )— wherein (i) R 6a is in the S configuration and is selected from the group consisting of —CH 3 , —CH 2 CH 3 , —CH. 2 —S—CH 3 , ——CH 2 OH, —CH 2 CN, —CH 2 C—CH, —CH 2 CH═CH 2 , and —CH═CH 2 and R 6b is hydrogen; or (ii) R 6b is hydrogen and R 6a is lower alkyl of 1 to about 3 carbon atoms, (d) R 7 is hydrogen or alkyl of 1 to about 4 carbon atoms; and (e) R 8 and R 9 are independently selected from the group consisting of hydrogen, hydroxy, halogen, alkyl of 1 to about 6 carbon atoms, alkyl of 1 to about 4 carbon atoms substituted with alkoxy of 1 to about 4 carbon atoms, alkoxy of 1 to about 6 carbon atoms, and trifluoromethyl; and pharmaceutically acceptable salts thereof.