Patent ID: 7361492

Claim:
A crystal comprising amino acids 107-403 of SEQ ID NO: 1, an unphosphorylated human Aurora-2 kinase domain, wherein the crystal is characterized with space group P3 2 21 and has unit cell parameters of a=b=87 Å, c=76 Å; α,β=90° and y=120°; and wherein said crystal further comprises a chemical entity selected from the group consisting of (5-Methyl-2H-pyrazol-3-yl)-(2-(pyridin-3-ylmethylamino)-quinazolin-4-yl)-amine, (5-Cyclopropyl-2H-pyrazol-3-yl)-(2-phenyl-quinazolin-4-yl)-amine, (5-Methylthiazol-2-yl)-(2-phenyl-quinazolin-4-yl) -amine, and adenosine.