Patent ID: 8916565

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: R 1 is H, C1-C8 alkyl, C3-C8 cycloalkyl, halo, CN, NR 8 SO 2 R 8 , SO 2 R 8 , SR 8 , SOR 8 , NR 8 COR 8 , NR 8 CO 2 R 8 , CON(R 8 ) 2 , SO 2 N(R 8 ) 2 , CF 3 , heterocycloalkyl, or a straight chain, branched, or cyclic (C3-C8)-R 9 wherein up to two CH 2 units may be replaced with O, CO, S, SO, SO 2 or NR 8 , or two R 1 taken together form an oxo group; R 2 is H, C1-C8 alkyl, halo, C1-C8 haloalkyl, CN, OH, SO 2 R 8 , SR 8 , SOR 8 , COR 8 , CO 2 R 8 , CON(R 8 ) 2 , SO 2 N(R 8 ) 2 , CF 3 , CHF 2 , or a straight chain, branched, or cyclic (C3-C8)-R 9 wherein up to two CH 2 units may be replaced with O, CO, S, SO, SO 2 , CF 2 , or NR 8 ; R 3 is H, C1-C8 alkyl, C3-C8 cycloalkyl, CO 2 R 8 , COR 8 , COH, CON(R 8 ) 2 , CF 3 , CH 2 CF 3 , CH 2 CHF 2 , or a straight chain, branched, or cyclic (C3-C8)-R 9 wherein up to two CH 2 units may be replaced with O, CO, S, SO, SO 2 or NR 8 ; R 4 is H, C1-C8 alkyl, halo, C3-C8 cycloalkyl, wherein up to two CH 2 units may be replaced by O, CO, S, SO, SO 2 , or NR 8 , or 2 R 4 taken together form a fused 3 to 7 membered cycloalkyl ring; R 8 is H, C1-C8 alkyl, CF 3 , C3-C8 cycloalkyl, fluoroalkyl, aryl, heteroaryl, or a straight chain, branched, or cyclic (C3-C8)-R 9 wherein up to two CH 2 units may be replaced with O, CO, S, SO, SO 2 or NR, or 2 R 8 taken together with the atoms to which they are attached form a ring; R 9 is H, CF 3 , CO 2 R, OH, aryl, heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, N(R) 2 , NRCOR, CON(R) 2 , CN, halo, or SO 2 R; R is H, C1-C8 alkyl, aryl, heteroaryl, C3-C8 cycloalkyl, or heterocycloalkyl; A is an aryl optionally substituted with one or more of C1-C8 alkyl, C3-C8 cycloalkyl, C1-C8 alkoxy, C3-C8 cycloalkoxy, halo, CN, OH, OR 8 , N(R 8 ) 2 , NR 8 SO 2 R 8 , OSO 2 R 8 , SO 2 R 8 , SOR 8 , SR 8 , CO 2 R 8 , NR 8 COR 8 , NR 8 CO 2 R 8 , CON(R 8 ) 2 , SO 2 N(R 8 ) 2 , CHF 2 , CF 3 , OCF 3 , OCHF 2 , R 9 , heterocycloalkyl, heterocycloalkoxy, aryl, heteroaryl, or a straight chain, branched, or cyclic (C3-C8)-(R 9 ) p wherein p is 1 or 2 and wherein up to three CH 2 units may be replaced with O, CO, S, SO, SO 2 , or NR 8 ; or wherein two adjacent substituents on A together with the carbons to which they are attached form a ring comprising up to 2 heteroatoms; m is 0, 1, 2, 3, or 4; n is 0, 1, 2, or 3; and o is 0, 1, 2, 3, or 4.