Patent ID: 7754746

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: R 1 is C 1 -C 6 -alkylaminocarbonyl, where the alkyl is optionally substituted by one or more halo, hydroxyl or C 1 -C 6 -alkoxy groups, or R 1 is a 5- or 6-membered heteroaromatic ring having one or more ring heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, said ring, being optionally substituted by one or more halo, hydroxyl, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy groups, where said alkyl and alkoxy are optionally further substituted by one or more halo, hydroxyl or C 1 -C 6 -alkoxy groups; R 2 is C 1 -C 3 -alkyl; R 3 is C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, —NR 5 R 6 or —OR 7 , where said alkyl and cycloalkyl groups are optionally substituted by one or more halo, hydroxyl or C 1 -C 6 -alkoxy groups and said cycloalkyl group is optionally further substituted by C 1 -C 6 -alkyl; R 4 is one or more optional phenyl substituents independently selected from halo, C 1 -C 6 -alkyl, hydroxyl or C 1 -C 6 -alkoxy, where said alkyl and alkoxy groups are optionally further substituted by one or more halo, hydroxyl and C 1 -C 6 -alkoxy groups; or R 3 and R 4 together form a fused 5-7 membered cycloalkanone ring; R 5 and R 6 independently represent hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, hydroxyl or C 1 -C 6 -alkoxy, where said alkyl, alkoxy and cycloalkyl groups are optionally substituted by one or more halo, hydroxyl or C 1 -C 6 -alkoxy groups and said cycloalkyl group is optionally further substituted by C 1 -C 6 -alkyl; R 7 is hydrogen, C 1 -C 6 -alkyl or C 3 -C 6 -cycloalkyl, where said alkyl and cycloalkyl groups are optionally substituted by one or more halo, hydroxyl or C 1 -C 6 -alkoxy groups and said cycloalkyl group is optionally further substituted by C 1 -C 6 -alkyl; X is CH 2 —C(R 8 )R 9 ; R 8 and R 9 are independently selected from hydrogen, halo, hydroxy and C 1 -C 6 -alkyl where said alkyl group is optionally substituted by one or more halo, hydroxyl or C 1 -C 6 -alkoxy groups; and the group C(O)R 3 is located at the 3- or 4-position on the phenyl ring.