Patent ID: 8048850

Claim:
A conjugate comprising: a protein selected from the group consisting of transferrin, holotransferrin, lactoferrin, and hololactoferrin having covalently coupled thereto one or more endoperoxides having the structure wherein R is C═O; CH—R 1 , where R 1 is (a) hydroxyl, (b) —O—C(O)—(CH 2 ) n —COOH where n is 1 to 6, or (c) —O—(CH 2 ) n —Ar—(CH 2 ) m —Y—NH 2 where n=1-3, m=0-3, Ar=aryl, and Y=—(C═O)NH—, —NH—, or —O—; or pharmaceutically acceptable salts thereof; wherein the one or more endoperoxides are covalently coupled through R to one or more polysaccharide groups on the protein through a linker comprising a hydrazide moiety, a hydrazine moiety, an aminoxy moiety, or a borate moiety.