Patent ID: 7732452

Claim:
A compound of formula (I): wherein X is O; R 1 is hydrogen or lower-alkyl; R 2 is hydrogen, halogen, lower-alkyl or fluoro-lower-alkyl; R 3 is hydrogen, halogen, lower-alkyl or fluoro-lower-alkyl; R 4 , R 5 , R 6 and R 7 independently from each other are hydrogen, halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl or fluoro-lower-alkoxy, or R 4 and R 5 are bound together to form a cycloalkyl together with the carbon atom to which they are attached and —R 4 —R 5 — is —(CH 2 ) 2-6 —, or R 6 and R 7 are bound together to form a cycloalkyl together with the carbon atom to which they are attached and —R 6 —R 7 — is —(CH 2 ) 2-6 —; or; R 4 and R 6 are bound together to form a ring and —R 4 —R 6 — is —(CH 2 ) 2-6 —; R 8 is aryl or heteroaryl, which aryl or heteroaryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, lower-alkyl, hydroxy-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, carboxy, carboxy-lower-alkyl, lower-alkoxy-carbonyl, lower-alkoxy-carbonyl-lower-alkyl, R 10 R 11 NC(O), R 10 R 11 NC(O)lower-alkyl, fluoro-lower-alkyl, R 10 R 11 N-lower-alkyl, lower-alkyl-SO 2 , lower-alkyl-SO 2 O, lower-alkyl-SO 2 —NR 10 , R 10 R 11 NSO 2 , cyano, NO 2 , cycloalkyl, lower-alkoxy-lower-alkyl, lower-alkenyl, lower-alkinyl, fluoro-lower-alkoxy-lower-alkyl, cyano-lower-alkyl, phenyl and heteroaryl, which phenyl or heteroaryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, lower-alkyl-C(O) and lower-alkyl-C(O)N(R 10 ); R 9 is hydrogen, lower-alkyl or fluoro-lower-alkyl; R 10 and R 11 independently from each other are hydrogen or lower-alkyl; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; or a pharmaceutically acceptable salt or a pharmaceutically acceptable ester thereof, with the proviso that the compound of formula (I) is not 2-methyl-4-[[(phenylmethoxy)carbonyl]amino]-3-thiophenecarboxylic acid methyl ester, 4-benzoxycarbonylamino-2-methylthiophen-3-carboxylic acid methyl ester, 4-methoxycarbonylamino-2-methylthiophen-3-carboxylic acid methyl ester, 3-(naphth-2-yl)-but-2-enoic acid-N-(3-carboxy-thiophen-4-yl)-amide or 3-(naphth-2-yl)but-2-enoic acid-N-(3-methoxycarbonyl-thiophen-4-yl), and with the proviso that if both m and n are 0 and R 1 is methyl, then R 8 is not nitro-phenyl.