Patent ID: 8563723

Claim:
A compound of formula (1): or a tautomer, stereoisomer, N-oxide, or a pharmacologically acceptable salt of any of the foregoing, wherein: R 1 is chosen from hydrogen and an alkyl(C 1-4 ) group optionally substituted with at least one substituent chosen from halogen and a hydroxyl group; R 2 and R 3 are independently chosen from hydrogen, a hydroxyl group, and an alkyl(C 1-4 ) group optionally substituted with at least one substituent Q, wherein each Q is independently chosen from: halogen, alkyl(C 1-4 ), alkenyl(C 1-4 ), alkynyl(C 1-4 ), CF 3 , NH 2 , NHalkyl(C 1-4 ), N[alkyl(C 1-4 )] 2 , OH, ═O, O-alkyl(C 1-4 ), and OCF 3 , R 1 and R 2 , together with the carbon atoms marked ‘a’ and ‘b’, form a C 5-8 -cycloalkyl ring, optionally substituted with at least one substituent chosen from halogen, a hydroxyl group, and an alkyl(C 1-4 ) group, or R 2 and R 3 , together with the carbon atom marked ‘b’, form a C 3-8 -cycloalkyl or a C 4-8 -heterocycloalkyl ring, optionally substituted with at least one substituent Q, as defined above; R 4 and R 5 are independently chosen from hydrogen and an alkyl(C 1-4 ) group optionally substituted with at least one substituent Q, as defined above, R 4 and R 5 are independently chosen from a monocyclic or fused bicyclic aromatic or hetero-aromatic groups, optionally substituted with at least one substituent Q, as defined above, or R 3 and R 4 , together with the carbon atoms marked ‘b’ and ‘c,’ form a C 3-8 -cycloalkyl or a C 5-8 -heterocycloalkyl ring, optionally substituted with at least one substituent Q, as defined above; R 6 and R 7 are independently chosen from hydrogen, an alkyl(C 1-4 ) group optionally substituted with at least one substituent chosen from halogen atom, a hydroxyl group, and a dialkyl(C 1-3 )-amino-alkyl(C 1-3 ) group, R 6 and R 7 are independently chosen from a monocyclic or fused bicyclic aromatic or hetero-aromatic group optionally substituted with at least one substituent Q, as defined above, R 6 and R 7 are independently chosen from a C 5-8 -cycloalkyl group and a C 5-8 -heterocycloalkyl group optionally substituted with at least one substituent Q, as defined above, or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a C 5-8 -heterocycloalkyl group optionally substituted with at least one substituent Q, as defined above; R 8 is chosen from: wherein: an asterisk (*) marks the bond to the S-atom, n is 0 or 1, is chosen from an aryl and heteroaryl group, X, Y and Z are independently chosen from C, N, O and S, with the proviso that bonds in the ring with X, Y, and Z are single or double bonds, any X, Y, or Z that is C or N is substituted with H-atoms only, and R and R′ are independently chosen from hydrogen, halogen, alkyl(C 1-4 ), alkenyl(C 1-4 ), alkynyl(C 1-4 ), CF 3 , NH 2 , NHalkyl(C 1-4 ), N[alkyl(C 1-4 )] 2 , OH, SH, keto, O-alkyl(C 1-4 ), S-alkyl(C 1-4 ), SO-alkyl(C 1-4 ), SO 2 -alkyl(C 1-4 ), OCF 3 , nitro and cyano, with the proviso that the compounds of formula (1) are not: