Patent ID: 8003792

Claim:
A compound of formula I: wherein: B is a bicycloheterocycle selected from the group consisting of: where T, U, V, W, X and Y are each independently a carbon atom or a nitrogen atom, wherein no more than two of T, U, V and W, and no more than three of T, U, V, W, X and Y, are a nitrogen atoms, B is unsubstituted or substituted with 1-5 substituents each independently selected from R 1 , R 2 , R 3a and R 3 b, wherein R 1 , R 2 , R 3a and R 3b are independently selected from: (1) —C 1-6 alkyl, which is unsubstituted or substituted with 1-5 substituents each independently selected from: (a) fluoro, (b) —CO 2 R 9 , wherein R 9 is independently selected from: —C 1-4 alkyl and —C 3-6 cycloalkyl, and (c) —CONR 10a R 11a , wherein R 10a and R 11 are each independently selected from: hydrogen and —C 1- 6alkyl, (2) phenyl or heterocycle, wherein heterocycle is selected from: pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolidinyl, thiazolyl, tetrahydrofuryl, and tetrahydrothiopyranyl, which phenyl or heterocycle is unsubstituted or substituted with 1-5 substituents each independently selected from: (a) —C 1- 6alkyl, which is unsubstituted or substituted with 1-3 fluoro, (b) halo, (c) —CO 2 R 9, (d) —(CO)R 9 , (e) oxo, (f) —S—C 1-4 alkyl, (g) —S(O)—C 1-4 alkyl, and (h) —SO 2 —C 1-4 alkyl, (3) halo, (4) —NR 10 R 11 , wherein R 10 and R 11 are each independently selected from: hydrogen, and —COR 9 ; or R 3a and R 3b and the carbon atom to which they are attached are joined to form a ring selected from cyclohexyl, piperidinyl, tetrahydropyranyl, and tetrahydrothiopyranyl, which ring is unsubstituted or substituted with 1-5 substituents each independently selected from: (a) —C 1-6 alkyl, which is unsubstituted or substituted with 1-3 substituents each independently selected from: halo, (b) hydroxy, (c) —CO 2 R 9 , and (d) oxo; A 1 and A 2 are each independently selected from: a bond and —CR 13 R 14 —, wherein R 13 and R 14 are hydrogen, wherein one of A 1 and A 2 is optionally absent; J is independently selected from: ═C(R 6a )—, —CR 13 R 14 — and —C(═O)—; K is independently selected from: ═C(R 6b )—, —CR 13 R 14 —, —C(═O)—; R 4 is independently selected from: hydrogen, C 1-6 alkyl which is unsubstituted or substituted with 1-6 fluoro, C 5-6 cycloalkyl, benzyl and phenyl; R 5a , R 5b and R 5c are hydrogen; R 6a and R 6b are hydrogen; or R 6a and R 6b and the atom(s) to which they are attached are joined to form a ring selected from phenyl, pyridyl and pyrimidinyl, which ring is unsubstituted or substituted with 1-5 substituents independently selected from halo; m is 1; n is 1; and pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof.