Patent ID: 7550153

Claim:
A method of treating ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD), or Zollinger-Ellison Syndrome in a mammalian subject, comprising the step of administering to the subject a plurality of pantoprazole multiparticulates, each of which comprise: a core consisting of about 45% w/w pantoprazole sodium sesquihydrate and one or more excipients comprising about 25% to 30% w/w microcrystalline cellulose, about 4% to 6% w/w polysorbate 80, about 14% to 16% w/w crospovidone, about 0.5 to 2% w/w hydroxypropyl methylcellulose, about 5% to 8% w/w sodium carbonate, and about 1 to about 2% water; an initial seal coat comprising hydroxypropylmethyl cellulose on the spheroid core; and an enteric coat on the initial coated spheroid core, wherein the multiparticulates have an average size in the range from about 0.7 mm to about 1.25 mm.