Patent ID: 6878721

Claim:
A compound of formula in free or salt or solvate form, where Ar is a group of formula R 1 is hydrogen, hydroxy, or alkoxy; R 2 and R 3 are each independently hydrogen or alkyl; R 4 , R 5 , R 6 and R 7 are each independently hydrogen, halogen, cyano, hydroxy, alkoxy, aryl, alkyl, alkyl substituted by one or more halogen atoms or one or more hydroxy or alkoxy groups, interrupted C 2 to C 10 alkyl in which one or more pairs of carbon atoms are linked by —O—, —NR—, —S—, —S(═O)— or —SO 2 —, where R is hydrogen or C 1 to C 10 alkyl, alkenyl, trialkylsilyl, carboxy, alkoxycarbonyl, or —CONR 11 R 12 , where R 11 and R 12 are each independently hydrogen or alkyl, or R 4 and R 5 , R 5 and R 6 , or R 6 and R 7 together with the carbon atoms to which they are attached denote a carbocyclic or a 5- or 6-membered O-heterocyclic ring containing one or two oxygen atoms; R 8 is halogen, —OR 13 , —CH 2 OR 13 or —NHR 13 where R 13 is hydrogen, alkyl, alkyl interrupted by one or more hetero atoms, —COR 14 , where R 14 is hydrogen, —N(R 15 )R 16 , alkyl or alkyl interrupted by one or more hetero atoms, or aryl and R 15 and R 16 are each independently hydrogen, alkyl or alkyl interrupted by one or more hetero atoms, or R 13 is —C(═NH)R 17 , —SOR 17 or —SO 2 R 17 where R 17 is alkyl or alkyl interrupted by one or more hetero atoms, and R 9 is hydrogen, or R 8 is —NHR 18 where —NHR 18 and R 9 , together with the carbon atoms to which they are attached, denote a 5- or 6-membered heterocycle; R 10 is —OR 19 or —NHR 19 where R 19 is hydrogen, alkyl, alkyl interrupted by one or more hetero atoms, or —COR 20 , where R 20 is —N(R 21 )R 22 , alkyl or alkyl interrupted by one or more hetero atoms, or aryl, and R 21 and R 22 are each independently hydrogen, alkyl or alkyl interrupted by one or more hetero atoms; X is halogen or halomethyl or alkyl; Y is carbon or nitrogen; n is 1 or 2; p is zero when Y is nitrogen or 1 when Y is carbon; q and r are each zero or 1, the sum of q+r is 1 or 2; and the carbon atom marked with an asterisk * has the R or S configuration, or a mixture thereof, when R 1 is hydroxy or alkoxy.