Patent ID: 8334381

Claim:
A process for the preparation of compounds of Formula 1′ in which R 1 represents nitro, amino, halogen, hydroxy, NH—C(O)—R 3 , NHR 4 , X represents hydrogen, chlorine, bromine, iodine, hydroxy, or OR 5 , R 3 represents 4-(halo-methyl)phenyl, 4-(hydroxymethyl)phenyl, 4-((4-methylpiperazinyl)carbonyl)phenyl, 4-(alkoxycarbonyl)phenyl, or 4-[(4-methyl-1-piperazinyl)methyl]phenyl, wherein alkoxy means C 1 -C 4 alkoxy, R 4 represents a protecting group for the amine group, R 5 represents an activating group for the hydroxyl group, comprising the reaction of the β-oxo-3-pyridinepropionic acid or an ester thereof of Formula 2 in which R 2 represents hydrogen, C 1 -C 4 alkyl, benzyl, or phenyl, with an aryl guanidine of Formula 3 in which R 1 has the meaning described above.