Patent ID: 8722671

Claim:
A method of treating Alzheimer's disease in a patient comprising administering to the patient at least one compound of the formula (I): wherein R 1 is H; R 2 is H; R 3 is H, NH-phenyl or NH-benzodioxolyl; R 4 is H, halogen, (C 1 -C 6 )alkyl; R 5 is H, halogen, (C 1 -C 6 )alkyl, cyclopropyl, phenyl, benzofuran, (C 1 -C 6 )alkylene-phenyl; R 6 is H, (C 1 -C 8 )alkyl, (C 1 -C 6 )alkylene-(C 10 )aryl, (C 1 -C 6 )alkylene-CH[phenyl] 2 , (C 1 -C 6 )alkylene-phenyl; R 7 is H, halogen, (C 1 -C 6 )alkyl, phenyl; R 8 is H, halogen, or (C 1 -C 6 )alkyl; n is 1, 2, 3 or 4; and L is O or O—(C 1 -C 6 )alkylene; wherein in residues R 4 , R 5 , R 7 and R 8 one alkyl or alkylene hydrogen atom can be optionally substituted by OH, OCH 3 , COOH, COOCH 3 , NH 2 , NHCH 3 , N(CH 3 ) 2 , CONH 2 , CONHCH 3 or CON(CH 3 ) 2 , and in any residue one or more alkyl or alkylene hydrogen atoms can optionally be substituted by F; and wherein phenyl or naphthyl groups are optionally substituted one or more times by (C 1 -C 4 )alkyl, O—(C 1 -C 4 )alkyl, O-phenyl, C(O)O—(C 1 -C 6 )alkyl, C(O)OH, C(O)—(C 1 -C 4 )alkyl, halogen, NO 2 , SO 2 NH 2 , CN, SO 2 —(C 1 -C 4 )alkyl, NH—SO 2 —(C 1 -C 4 )alkyl, NH 2 , NH—C(O)—(C 1 -C 4 )alkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkyl-OH, C(O)N[(C 1 -C 4 )alkyl] 2 , C(O)NH 2 , N[(C 1 -C 4 )alkyl] 2 , (C 2 -C 4 )alkenylene-(C 6 -C 10 )aryl, wherein the (C 6 -C 10 )aryl may be further substituted with (C 1 -C 4 )alkyl, (C 1 -C 4 )alkylene-O—(C 1 -C 6 )alkyl, O—(C 1 -C 6 )alkyl-(C 6 -C 10 )aryl, or may be vicinal substituted by a O—(C 1 -C 4 )alkylene-O group whereby a 5-8-membered ring is formed together with the carbon atoms the oxygen atoms are attached to, and wherein the benzofuran or benzodioxolyl groups are optionally substituted one or more times with (C 1 -C 4 )alkyl, O—(C 1 -C 4 )alkyl, halogen or (C 1 -C 4 )alkylene-O—(C 1 -C 4 )alkyl, or a pharmaceutically acceptable salt and physiologically functional derivative thereof.