Patent ID: 8569282

Claim:
A compound of formula I-A: or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen; alkyl, alkoxyalkyl, alkoxyphenyl, alkylthioalkyl, alkylamino, —SO 2 (alkyl), C 3-6 cycloalkyl, C 3-6 heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which is optionally substituted with 1, 2, or 3 R 5 substituents; or R 1 is optionally substituted (C 1 -C 6 alkylene)-R 1a , wherein R 1a is C 3-6 cycloalkyl, C 3-6 heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted with 1, 2, or 3 R 5 substituents; Y is a direct bond or is CO, SO 2 , —N(H)CO, —N(H)SO 2 , C(═NH), C 1-4 alkylene, C 2-4 alkenylene, C 2-4 alkynylene, C 3-6 cycloalkylene, arylene, heterocycloalkylene, heteroarylene, —C(O)alkylene, —N(H)C(O)alkylene, or —O-alkylene; each of which may be optionally substituted with 1, 2, or 3 R 5 substituents; R 3 is wherein R 11 is hydrogen or is C 1-6 alkyl, (C 1 -C 6 alkylene)cycloalkyl, aralkyl, or heteroaralkyl, any of which may be optionally substituted with halo, hydroxy, alkyl, alkenyl, cycloalkyl, C 1-3 alkoxy, —CO 2 H, —CO 2 C 1-3 alkyl, cyano, aryl, heteroaryl, —CF 3 , —O—CF 3 , —O—CH 2 F, or —O—CHF 2 ; R 4 is hydrogen; halo; C 1-8 alkyl, alkenyl, or alkynyl optionally interrupted by oxygen or sulfur; cycloalkyl; alkoxy; arylalkoxy; or heteroarylalkoxy; R 5 , when present, represents independently for each occurrence hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, alkoxy, —CO 2 H, —CO 2 C 1-3 alkyl, cyano, aryl, heteroaryl, aralkyl, heteroaralkyl, oxo, —CF 3 , —O—CF 3 , —O—CHF 2 , —O—CH 2 F, —O-aryl, —N(H)alkyl, —N(H)SO 2 -alkyl, —N(H)C(O)alkyl, —SO 2 N(H)alkyl, —SO 2 N(alkyl)C(O)alkyl, or —C(O)N(H)SO 2 alkyl; n is 0 or 1; p is 1; A 1 , A 2 , A 3 , and A 4 are independently N or C—R 5 , provided that at least two of A 1 , A 2 , A 3 , or A 4 are C—R 5 ; and optionally substituted with 1 or 2 halo, methyl, or ethyl groups, or is geminally substituted to form a cyclopropyl ring.