Patent ID: 7498442

Claim:
A pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: R 1 is hydrogen, halo, hydroxy, C 1-4 alkyl, or C 1-4 alkoxy; R 2 is C 3-4 alkyl or C 3-6 cycloalkyl; R 3 is hydroxy, C 1-3 alkoxy, hydroxy-substituted C 1-4 alkyl, or —OC(O)NR a R b ; R 4 is hydrogen or C 1-4 alkyl; X is selected from —N(R 8 )C(O)R 9 , —N(R 8 )S(O) 2 R 10 , —S(R 11 )O 2 , —N(R 8 )C(O)OR 12 , —N(R 8 )C(O)NR 13 R 14 , —N(R 8 )SO 2 NR 13 R 14 , —C(O)NR 13 R 14 , —OC(O)NR 13 R 14 , —C(O)OR 12 , —OR 15 , and cyano; R 5 is hydrogen or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with hydroxy, C 1-3 alkoxy, or cyano; R 6 and R 7 are independently selected from hydrogen, hydroxy, halo, and C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with hydroxy or C 1-3 alkoxy; R 8 is hydrogen or C 1-4 alkyl; or R 5 and R 8 , R 5 and R 6 , or R 6 and R 8 taken together form C 2-5 alkylenyl, wherein C 2-5 alkylenyl is optionally substituted with hydroxy, halo, hydroxy-substituted C 1-3 alkyl, or C 1-3 alkoxy; or R 3 and R 5 taken together form —OCH 2 CH 2 —; or R 5 and R 6 taken together form —(CH 2 ) q -Q-(CH 2 ) q , wherein Q is oxygen or sulfur and q is independently 0, 1, or 2; R 9 is hydrogen, furanyl, or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with hydroxy or with from 1 to 3 halo; R 10 is hydrogen or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with —SO 2 R c , C 3-6 cycloalkyl or with from 1 to 3 halo; or R 8 and R 10 taken together form C 3 alkylenyl; R 11 is hydrogen, C 1-4 alkyl, or —NR b R c ; or R 5 and R 11 or R 6 and R 11 taken together form C 2-5 alkylenyl; R 12 , R 13 , and R 14 are independently hydrogen or C 1-4 alkyl; R 15 is hydrogen or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with hydroxy; R a , R b , and R c are independently hydrogen or C 1-3 alkyl; and n is 1, 2, 3, or 4; provided that when n is 1, X forms a carbon-carbon bond with the carbon atom bearing the substituents R 6 and R 7 ; or a pharmaceutically-acceptable salt or stereoisomer thereof.