Patent ID: 8657601

Claim:
An implant for application in bone, which comprises: a) at least one surface, having an underlying basic or starting structure derived from mechanical working, b) having a topographic modification on said basic or starting surface structure, which topographic modification gives a surface structure or surface structures formed by shot-peening, etching, plasma spraying and/or chemical action, and c) rhBMP bone-growth-stimulating and/or rhBMP bone-growth-maintaining agent supported by the topographically modified surface structure, wherein said rhBMP bone-growth-stimulating and/or rhBMP bone-growth-maintaining agent is selected from the group consisting of rhBMP-2, rhBMP-4 and rhBMP-7, wherein the modified surface structure has pits wherein the average distance between the deepest parts of the pits is about 10-20 μm and the minimum depth of the pits is about 1 μm, and wherein said surface structure is formed by anodic oxidation and the modified surface structure comprises a porous oxide layer.