Patent ID: 8017616

Claim:
A compound having the general structure shown in Formula 1 or a pharmaceutically acceptable salt thereof, wherein: Z is N, NO, or NOH; G is selected from the group consisting of: wherein is a single bond or double bond, R 8 and R 9 are optional substituents, and two independent R 9 substituents may be substituted on the same ring carbon when the valency so permits; R 3 is selected from the group consisting of H, —CH 3 , —CH 2 CH 3 , cyclopropyl, —F, —Cl, —OCH 3 , —OCF 3 , and —CF 3 ; R 5 is selected from the group consisting of H, alkyl, halogen, and CF 3 ; R 6 is selected from the group consisting of H, alkyl, halogen, hydroxyalkyl, —CN, —N(R 30 ) 2 , —OR 30 , —N═CH-alkyl, and —NR 30 C(═O)alkyl; R 8 is H; R 9 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, —C(═O)N(H)R 30 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q N(R 31 ) 2 , —N(H)R 30 , and —N(R 30 ) 2 ; R 10 is selected from the group consisting of H, alkyl, aralkyl, and hydroxyalkyl, or wherein two R 10 taken together with the carbon atom to which both are attached is >C═O; the R 11 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, and hydroxyalkyl, wherein two R 11 taken together with the carbon atom to which both are attached form >C═O; R 12 is selected from the group consisting of H, CN, —C(═O)N(R 30 ) 2 and alkyl; D is selected from the group consisting of L is CH or N; the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, amino, halogen, CH 3 , CF 3 , OCF 3 , —(CH 2 ) q OR 31 , and —(CH 2 ) q NHR 31 , Y is selected from the group consisting of —CH 2 —, —CH(CH 3 )—, —CH(CH 2 OH)—, —C(═O)— and —CH(CO 2 alkyl)-; the R 30 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, aralkyl, cycloalkyl, —(CH 2 ) q OH, —(CH 2 ) q Oalkyl, —(CH 2 ) q NH 2 , —(CH 2 ) q NHalkyl, —(CH 2 ) q N(alkyl) 2 , —(CH 2 ) q NHaralkyl, —(CH 2 ) q C(═O)NHalkyl, —(CH 2 ) q C(═O)N(alkyl) 2 , —(CH 2 ) q C(═O)NHaralkyl, —(CH 2 ) q SO 2 alkyl, and —(CH 2 ), q SO 2 NHalkyl; the R 31 moieties can be the same or different, each being independently selected from the group consisting of alkyl, aralkyl, cycloalkyl, —(CH 2 ) q OH, —(CH 2 ) q Oalkyl, —(CH 2 ) q NH 2 , —(CH 2 ) q NHalkyl, —(CH 2 ) q N(alkyl) 2 , —(CH 2 ) q NHaralkyl, —(CH 2 ) q C(═O)NHalkyl, —(CH 2 ) q C(═O)N(alkyl) 2 , —(CH 2 ) q C(═O)NHaralkyl, —(CH 2 ) q SO 2 alkyl, and —(CH 2 ) q ,SO 2 NHalkyl; m is 0 to 4; n is 0 to 4; p is 1 to 5; and each q can be the same or different, each being 1 or 2.