Patent ID: 8722887

Claim:
A compound of formula (1 X ): or a stereoisomer, N-oxide thereof, or pharmacologically acceptable salt of any of the foregoing, wherein: X is chosen from halogen and S-alkyl(C 1-4 ); R 1 is chosen from hydrogen, an unsubstituted alkyl(C 1-4 ) group, and an alkyl(C 1-4 ) group substituted with one or more halogen atoms; R 2 and R 3 independently are chosen from hydrogen, an unsubstituted alkyl(C 1-4 ) group, an alkyl-(C 1-4 ) group substituted with one or more halogen atoms, and a phenyl-alkoxy(C 1-4 )-alkyl(C 1-4 ) group optionally substituted with one or more halogen atoms, or, R 1 and R 2 , together with the carbon atoms marked ‘a’ and ‘b’ form a C 5-8 -cycloalkyl ring, or R 2 and R 3 , together with the carbon atom marked ‘b’ form a C 3-8 -cycloalkyl ring, or, R 2 and R 3 , together with the carbon atom marked ‘b’ form an C 5-8 -heterocycloalkyl ring optionally substituted with one or more substituents Y, wherein Y is chosen from (C 1-3 )alkyl, tri-fluoromethyl, fluoro, chloro, bromo, hydroxyl, (C 1-3 )alkyloxy, trifluoromethoxy, and amino; R 4 and R 5 independently are chosen from hydrogen, an unsubstituted alkyl(C 1-4 ) group, an alkyl-(C 1-4 ) group substituted with one or more halogen atoms, a monocyclic or a fused-bicyclic aromatic or hetero-aromatic group, optionally substituted with one or more substituents Y, as defined above, or, R 3 and R 4 , together with the carbon atoms marked ‘b’ and ‘c’ form a C 3-8 -cycloalkyl ring, or, R 3 and R 4 , together with the carbon atoms marked ‘b’ and ‘c’ form a C 5-8 -heterocycloalkyl ring, optionally substituted with one or more substituents Y, as defined above; and R 8 is a monocyclic or a fused-bicyclic aromatic or hetero-aromatic group, optionally substituted with one or more substituents Y, as defined above, or, R 8 is a —CR 9 ═CR 10 -aryl group wherein R 9 and R 10 independently are chosen from hydrogen and an alkyl-(C 1-3 ) group, and wherein aryl is chosen from a monocyclic, a fused bicyclic aromatic, and a hetero-aromatic group, or, R 8 is chosen from a —C≡C-aryl group, wherein aryl is chosen from a monocyclic, a fused bicyclic aromatic, and a hetero-aromatic group, a piperidinyl group optionally substituted with one or more substituents Y, as defined above, and a —NR 11 R 12 group, wherein R 11 and R 12 independently are chosen from hydrogen, an unsubstituted alkyl-(C 1-3 ) group, and a phenyl or benzyl group, wherein the phenyl or benzyl group is optionally substituted with one or more substituents Y, as defined above.