Patent ID: 7238713

Claim:
A compound of formula (I): wherein: Z 1 is CR 1 , Z 2 is CR 2 , Z 3 is CR 3 , and Z 4 is CR 4 ; W 1 is S, W 2 is N or CR 6 , and W 3 is CG; G is of formula (II): Y is O, S, CHOH, —NHC(O)—, —C(O)NH—, —C(O)—, —OC(O)—, —(O)CO—, —NR 7 —, —CH═N—, or absent; p is 1, 2, 3, 4 or 5; Z is CR 8 R 9 or absent; each t is 1, 2, or 3; each R 1 , R 2 , R 3 , and R 4 , independently, is H, amino, hydroxyl, halo, or straight- or branched-chain C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, methoxymethyl, ethoxymethyl, proproxymethyl, C 1-6 haloalkyl, —CN, —CF 3 , —OR 11 , —COR 11 , —NO 2 , —SR 11 , —NHC(O)R 11 , —C(O)NR 12 R 13 , —NR 12 R 13 , —NR 11 C(O)NR 12 R 13 , —SO 2 NR 12 R 13 , —OC(O)R 11 , —O(CH 2 ) q NR 12 R 13 , or —(CH 2 ) q NR 12 R 13 , where q is an integer from 2 to 6, or R 1 and R 2 together form —NH—N═N— or R 3 and R 4 together form —NH—N═N—; each R 5 , R 6 , and R 7 , independently, is H, C 1-6 alkyl; formyl; C 3-6 cycloalkyl; C 5-6 aryl, optionally substituted with halo or C 1-6 alkyl; or C 5-6 heteroaryl, optionally substituted with halo or C 1-6 alkyl; each R 8 and R 9 , independently, is H or straight- or branched-chain C 1-8 alkyl; R 10 is straight- or branched-chain C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkylidene, C 1-8 alkoxy, or methoxymethyl, ethoxymethyl, proproxymethyl; R 10 ′ is H, straight- or branched-chain C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkylidene, C 1-8 alkoxy, methoxymethyl, ethoxymethyl, proproxymethyl, C 1-8 aminoalkyl, C 1-8 haloalkyl, C 1-8 alkoxycarbonyl, C 1-8 hydroxyalkoxy, C 1-8 hydroxyalkyl, or C 1-8 alkylthio; each R 11 , independently, is H, straight- or branched-chain C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, methoxymethyl, ethoxymethyl, proproxymethyl, C 2-8 aminoalkyl, C 2-8 haloalkyl, C 1-8 alkoxycarbonyl, C 2-8 hydroxyalkyl, —C(O)—C 5-6 aryl substituted with C 1-3 alkyl or halo, C 5-6 aryl, C 5-6 heteroaryl, C 5-6 cycloalkyl, C 5-6 heterocycloalkyl, —C(O)NR 12 R 13 , —CR 5 R 12 R 13 , —(CH 2 ) t NR 12 R 13 , t is an integer from 2 to 8; and each R 12 and R 13 , independently, is H, C 1-6 alkyl; C 3-6 cycloalkyl; C 5-6 aryl, optionally substituted with halo or C 1-6 alkyl; or C 5-6 heteroaryl, optionally substituted with halo or C 1-6 alkyl; or a pharmaceutically acceptable salt, ester or prodrug thereof.