Patent ID: 8063101

Claim:
A method of treating a disorder associated with platelet aggregation in a subject comprising administering to a subject who would benefit from such treatment a pharmaceutically acceptable composition comprising a therapeutically effective amount of a carotenoid analog or derivative wherein the carotenoid analog or derivative has the structure where each R 3 is independently hydrogen or methyl, and where R 1 and R 2 are each independently: where each R 5 is independently hydrogen, —CH 3 , —OH, —CH 2 OH or —OR 6 wherein at least one R 5 group in the carotenoid analog or derivative is —OR 6 ; wherein each R 6 is independently: H; alkyl; aryl; -alkyl-N(R 7 ) 2 ; -aryl-N(R 7 ) 2 ; -alkyl-N + (R 7 ) 3 ; -aryl-N + (R 7 ) 3 ; -alkyl-CO 2 R 9 ; -aryl-CO 2 R 9 ; -alkyl-CO 2 − ; -aryl-CO 2 − ; —C(O)-alkyl-N(R 7 ) 2 ; —C(O)-aryl-N(R 7 ) 2 ; —C(O)-alkyl-N + (R 7 ) 3 ; —C(O)-aryl-N + (R 7 ) 3 ; —C(O)-alkyl-CO 2 R 9 ; —C(O)-aryl-CO 2 R 9 ; -C(O)-alkyl-CO 2 − ; —C(O)-aryl-CO 2 − ; —C(O)—(NR 7 )-alkyl-N(R 7 ) 2 ; —C(O)—(NR 7 )-aryl-N(R 7 ) 2 ; —C(O)—(NR 7 )-alkyl-N + (R 7 ) 3 ; —C(O)—(NR 7 )-aryl-N + (R 7 ) 3 ; —C(O)—(NR 7 )-alkyl-CO 2 R 9 ; —C(O)—(NR 7 )-aryl-CO 2 R 9 ; —C(O)—(NR 7 )-alkyl-CO 2 − ; —C(O)—(NR 7 )-aryl-CO 2 − ; —C(O)—(NR 7 )-alkyl-N(R 7 )-alkyl-N(R 7 ) 2 ; —C(O)—OR 8 ; —P(O)(OR 8 ) 2 ; —S(O)(OR 8 ) 2 ; —C(O)—[C 6 -C 24 saturated hydrocarbon]; —C(O)—[C 6 -C 24 monounsaturated hydrocarbon]; —C(O)—[C 6 -C 24 polyunsaturated hydrocarbon]; a peptide; a carbohydrate; a nucleoside reside; or a co-antioxidant; where R 7 is hydrogen, alkyl, or aryl; where R 8 is hydrogen, alkyl, aryl, benzyl or a co-antioxidant; and where R 9 is hydrogen, alkyl, aryl, —P(O)(OR 8 ) 2 , —S(O)(OR 8 ) 2 , an amino acid, a peptide, a carbohydrate, a nucleoside, or a co-antioxidant.