Patent ID: 7329528

Claim:
A detergent composition comprising an enzyme dimer comprises a first subtilisin monomer unit having enzymatic activity and a second subtilisin monomer unit having enzymatic activity, wherein said first subtilisin unit and said second subtilisin unit are derived from an enzymatically active Bacillus subtilisin precursor and said first subtilisin unit and said second subtilisin unit differ from the corresponding precursor by the substitution or addition of a cysteine residue therein, wherein the cysteine residues are covalently bound to each other through a disulfide bond which attaches the first subtilisin unit to the second subtilisin unit and wherein the cysteine residues are located at a position other than the catalytically active site and the substrate binding site of each monomer unit, and wherein the first monomer unit and the second monomer unit are covalently bound to each other through a disulfide bond located at a position corresponding to residue position 24 of the Bacillus subtilisin designated GG36.