Patent ID: 7582733

Claim:
A humanized antibody; which specifically binds to beta amyloid peptide (Aβ) with a binding affinity of at least 10 7 M −1 , or antigen binding fragment thereof selected from the group consisting of a Fab, a Fab′, F(ab′) 2 , a FV, and a single-chain antibody, wherein the humanized antibody comprises: (i) a humanized light chain comprising three complementarity determining regions (CDR1, CDR2, and CDR3) from the 3D6 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:2, and a light chain variable region framework sequence, wherein at least three framework positions selected from the group consisting of L1, L2, L36, and L46 (Kabat numbering convention) are occupied by Y, V, L and R, respectively, and (ii) a humanized light chain comprising three comnplementarity determining regions (CDR1, CDR2, and CDR3) from the 2D6 immunoglobulin heavy chain variable region sequence set forth as SEQ ID NO:4, and a heavy chain variable regions framework sequence, wherein framework positions H49, H93, and H94 (Kabat numbering convention) are occupied by A, V, and R respectively.