Patent ID: 7462721

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, and including enol and tautomeric resonance isomers; wherein: X 1 is NR, or N; X 2 is CR 2 ; X 3 is CR 3 ; X 4 is CR 4 ; X 5 is CR 5 ; R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are independently selected from H, F, Cl, Br, I, OH, amino (—NH 2 ), ammonium (—NH 3 + ), alkylamino, dialkylamino, trialkylammonium, C 1 -C 8 alkyl, C 1 -C 8 alkylhalide, carboxylate, sulfate, sulfamate, sulfonate, 5-7 membered ring sultam, C 1 -C 8 alkylsulfonate, C 1 -C 8 alkylamino, 4-dialkylaminopyridinium, C 1 -C 8 alkylhydroxyl, C 1 -C 8 alkylthiol, alkylsulfone (—SO 2 R), arylsulfone (—SO 2 Ar), arylsulfoxide (—SOAr), arylthio (—SAr), sulfonamide (—SO 2 NR 2 ), alkylsulfoxide (—SOR), formyl (—CHO), ester (—C(═O)OR), amido (—C(═O)NR 2 ), 5-7 membered ring lactam, 5-7 membered ring lactone, nitrile (—CN), azido (—N 3 ), nitro (—NO 2 ), C 1 -C 8 alkoxy (—OR), C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heteroaryl, and C 2 -C 20 substituted heteroaryl, phosphonate, phosphate, polyethyleneoxy, and a phosphonate prodrug moiety; R 2 is selected from H, F, Cl, Br, I, OH, amino (—NH 2 ), ammonium (—NH 3 + ) alkylamino, dialkylamino, trialkylammonium, C 1 -C 8 alkyl, C 1 -C 8 alkylhalide, carboxylate, sulfate, sulfamate, sulfonate, 5-7 membered ring sultam, C 1 -C 8 alkylsulfonate, C 1 -C 8 alkylamino, 4-dialkylaminopyridinium, C 1 -C 8 alkylhydroxyl, C 1 -C 8 alkylthiol, alkylsulfone (—SO 2 R), arylsulfone (—SO 2 Ar), arylsulfoxide (—SOAr), arylthio (—SAr), sulfonamide (—SO 2 NR 2 ), alkylsulfoxide (—SOR), formyl (—CHO), ester (—C(═O)OR), amido (—C(═O)NR 2 ), 5-7 membered ring lactam, 5-7 membered ring lactone, nitrile (—CN), azido (—N 3 ), nitro (—NO 2 ), C 1 -C 8 alkoxy (—OR), C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heteroaryl, and C 2 -C 20 substituted heteroaryl, phosphonate, phosphate, polyethyleneoxy, a phosphonate prodrug moiety, OC(═O)OR, OC(═O)NR 2 , OC(═O)R, OSO 2 NR 2 (sulfamate), NR 2 , NRSO 2 R, SR, S(O)R, SO 2 R or SO 2 NR 2 (sulfonamide), lactam having the structures: sultam having the structures: R is independently selected from H, C 1 -C 8 alkyl, C 1 -C 8 substituted alkyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heteroaryl, and C 2 -C 20 substituted heteroaryl; L is selected from a bond, O, S, NR, N—OR, C 1 -C 12 alkylene, C 1 -C 12 substituted alkylene, C 2 -C 12 alkenylene, C 2 -C 12 substituted alkenylene, C 2 -C 12 alkynylene, C 2 -C 12 substituted alkynylene, C(═O)NH, C(═O), S(═O) 2 , C(═O)NH(CH 2 ) n , and (CH 2 CH 2 O) n , where n may be 1, 2, 3, 4, 5, or 6; and Ar is covalently attached to L and to one or more R 6 and Ar is selected from C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heteroaryl, and C 2 -C 20 substituted heteroaryl; where at least one of R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 comprises a phosphonate group.