Patent ID: 8268887

Claim:
A compound comprising a first moiety, a second moiety, and a physiologically labile linker that covalently links the first moiety to the second moiety, wherein the first moiety is covalently linked via an amino terminus to the linker, wherein the first moiety is γ-aminobutyric acid (GABA) or an analog or derivative of GABA, the second moiety is a nonsteroidal anti-inflammatory drug (NSAID) or γ-hydroxybutyric acid (GHB) or an analog or derivative of GHB, and the linker has the structure of wherein R 6 and R 7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, acyl, substituted alkoxycarbonyl, substituted alkoxycarbonyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, carbamoyl, cycloalkyl, substituted cycloalkyl, cycloalkoxycarbonyl, substituted cycloalkoxycarbonyl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl; wherein the second moiety is covalently linked to the linker via a carboxylic acid or a hydroxyl group.