Patent ID: 8610075

Claim:
A method for cardiac imaging, comprising: administering to an adult human subject an amount of a 99m Tc-containing species having a radioactivity of less than 5 mCi at a time of administration; and performing a SPECT imaging procedure of a cardiac region of interest (ROI) of the subject, wherein said 99m Tc-containing species has the formula 99m TcX(Y) 3 Z, wherein: X is an anion; each Y, which is independently chosen, is a vicinal dioxime having the formula HON═C(R 1 )C(R 2 )═NOH or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are each independently hydrogen, halogen, alkyl, aryl, amino or a 5 or 6-membered nitrogen or oxygen containing heterocycle, or together R 1 and R 2 are —(CR 8 CR 9 ) n — wherein n is 3, 4, 5 or 6 and R 8 and R 9 are each independently hydrogen or alkyl; and Z is a boron derivative of the formula B—R 3 wherein R 3 is hydroxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, carboxyalkyl, carboxyalkenyl, hydroxyalkyl, hydroxyalkenyl, alkoxyalkyl, alkoxyalkenyl, haloalkyl, haloalkenyl, aryl, arylalkyl or (R 4 R 5 N)-alkyl and R 4 and R 5 are each independently hydrogen, alkyl, or arylalkyl, or R 4 and R 5 when taken together with the nitrogen atom to which they are attached form a 5 or 6-membered nitrogen containing heterocycle.