Patent ID: 7598030

Claim:
A method comprising: collecting antiserum from non-human subjects immunized with non-cancerous human cells; contacting the antiserum with cancer cells to provide masked cancer cells; immunizing a subject with a composition comprising the masked cancer cells; and recovering antibodies that bind to the cancer cells from the subject, wherein the recovering step comprises a) generating an antibody library from subjects immunized with a composition comprising the masked cancer cells; b) removing from the library i) antibodies that bind to human red and white blood cells and ii) antibodies that bind to at least one other type of non-cancerous cell selected from the group consisting of endothelial cells, epithelial cells, smooth muscle cells, liver cells, lung cells, heart cells, kidney cells, intestine cells, stomach cells, bladder cells, spleen cells, pancreas cells, bone marrow cells, brain cells, thymus cells, prostate cells, ovary cells, testis cells and skin cells; and c) then recovering from the library antibodies that bind to the cancer cell.