Patent ID: 8084256

Claim:
A method for producing cytotoxic T cells specific to Ig E self antigenic peptides, wherein said self antigenic peptides are one or more peptides selected from the group consisting of: TQSPSVFPL (SEQ ID NO: 64), SLNGTTMTL (SEQ ID NO: 50), TMTLPATTL (SEQ ID NO:69), TLPATTLTL (SEQ ID NO:67), TLSGHYATI (SEQ ID NO:68), WVDNKTFSV (SEQ ID NO: 51), WLSDRTYTC (SEQ ID NO: 52), ALMRSTTKT (SEQ ID NO: 65), NFMPEDISV (SEQ ID NO: 79), YATISLLTV (SEQ ID NO: 58), TLTVTSTLPV (SEQ ID NO:56), SVQWLHNEV (SEQ ID NO: 76), QWLHNEVQL (SEQ ID NO: 80), TLACLIQNFM (SEQ ID NO: 59), and QVMDVDLSTA (SEQ ID NO: 60) comprising the steps of: (a) isolating CD8+ T cells from a subject; (b) loading antigen presenting cells having Class I MHC molecules on their surface with the IgE self antigenic peptides; (c) culturing the CD8+ T cells with the antigen presenting cells for a period of time sufficient for activation of precursor CD8+ T cells specific for the antigenic peptides; (d) expanding in culture the activated CD8+ T cells; and, (e) collecting CD8+ T cells from the culture.