Patent ID: 7005443

Claim:
A method for lowering and controlling normal or elevated intraocular pressure, which comprises administering a pharmaceutically effective amount of a compound of the formula: wherein G is chosen from hydrogen, halogen, or C 1-4 alkyl; R is hydrogen, C 1-4 alkyl, C(═O)W, or P(═O)(OX)(OY), R 1 and R 2 are hydrogen; R 3 and R 4 are independently chosen from hydrogen, C 1-4 alkyl or R 3 , R 4 and the carbon atom to which they are attached can form a cyclopropyl ring, or furthermore, R 2 and R 3 together can be (CH 2 ) m to form a saturated heterocycle; when R 2 and R 3 are part of a heterocycle, R 1 can be hydrogen or C 1-4 alkyl; R 5 can be hydrogen or C 1-4 alkyl; when R, R 1 , R 2 , R 5 , and G all are hydrogen R 3 and R 4 cannot both be hydrogen; W is C 1-6 alkyl, NR 6 R 7 , N(R 6 )CH 2 (CH 2 ) n C(═O)N(R 7 )(R 8 ), OC 1-6 alkyl, C 1-6 alkyl (which can be substituted with halogen, hydroxyl, CO 2 C 1-4 alkyl, CON(C 1-4 alkyl) 2 ,C(═NH)NH 2 , HC(═NH)NH 2 , NH 2 ), C 2-4 alkenyl (substituted by phenyl, unsubstituted or substituted with one or more of C 1-4 alkyl, C 1-4 alkoxy or halogen); R 6 , R 7 , R 8 are independently chosen from hydrogen or C 1-4 alkyl; X and Y are independently chosen from hydrogen, C 1-10 or alkyl or X and Y can together form a lower alkyl chain of (CH 2 ) m ; m is 2–4; n is 1 or 2; and pharmaceutically acceptable salts and solvates of the compounds.