Patent ID: RE41065

Claim:
A compound of the formula or a pharmaceutically acceptable salt thereof wherein: m is 1, 2, or 3; each R 1 is independently selected from the group consisting of hydrogen, halo, hydroxy, hydroxyamino, carboxy, nitro, guanidino, ureido, cyano, trifluoromethyl, and -(C 1 -C 4 alkylene)-W-(phenyl) wherein W is a single bond, O, S or NH; or each R 1 is independently selected from R 9 and C 1 -C 4 -alkyl substituted by cyano, wherein R 9 is selected from the group consisting of R 5 , —OR 6 , —NR 6 R 6 , —C(O)R 7 , —NHOR 5 , —OC(O)R 6 , cyano, A and —YR 5 ; R 5 is C 1 -C 4 alkyl; R 6 is independently hydrogen or R 5 ; R 7 is R 5 , —OR 6 or —NR 6 R 6 ; A is selected from piperidino, morpholino, pyrrolidino, 4-R 6 -piperazin-1-yl, imidazol-1-yl, 4-pyridon-1-yl, -(C 1 -C 4 alkylene) (CO 2 H), phenoxy, phenyl, phenylsulfanyl, C 2 -C 4 alkenyl, and -(C 1 -C 4 alkylene)C(O)NR 6 R 6 ; and Y is S, SO, or SO 2 ; wherein the alkyl moieties in R 5 , —OR 6 and —NR 6 R 6 are optionally substituted by one to three halo substituents and the alkyl moieties in R 5 , —OR 6 and —NR 6 R 6 are optionally substituted by 1 or 2 R 9 groups, and wherein the alkyl moieties of said optional substituents are optionally substituted by halo or R 9 , with the proviso that two heteroatoms are not attached to the same carbon atom; or each R 1 is independently selected from —NHSO 2 R 5 , phthalimido-(C 1 -C 4 ) -alkylsulfonylamino, benzamido, benzenesulfonylamino, 3-phenylureido, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, and R 10 -(C 2 -C 4 ) -alkanoylamino wherein R 10 is selected from halo, —OR 6 , C 2 -C 4 alkanoyloxy, —C(O)R 7 , and —NR 6 R 6 ; and wherein said —NHSO 2 R 5 , phthalimido-(C 1 -C 4 -alkylsulfonylamino, benzamido, benzenesulfonylamino, 3-phenylureido, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, and R 10 -(C 2 -C 4 )-alkanoylamino R 1 groups are optionally substituted by 1 or 2 substituents independently selected from halo, C 1 -C 4 alkyl, cyano, methanesulfonyl and C 1 -C 4 alkoxy; or two R 1 groups are taken together with the carbons to which they are attached to form a 5-8 membered ring that includes 1 or 2 heteroatoms selected from O, S and N; R 2 is hydrogen or C 1 -C 6 alkyl optionally substituted by 1 to 3 substituents independently selected from halo, C 1 -C 4 alkoxy, —NR 6 R 6 , and —SO 2 R 5 ; n is 1 or 2 and each R 3 is independently selected from hydrogen, halo, hydroxy, C 1 -C 6 alkyl, —NR 6 R 6 , and C 1 -C 4 alkoxy, wherein the alkyl moieties of said R 3 groups are optionally substituted by 1 to 3 substituents independently selected from halo, C 1 -C 4 alkoxy, —NR 6 R 6 , and —SO 2 R 5 ; and, R 4 is azido or -(ethynyl)-R 11 wherein R 11 is hydrogen or C 1 -C 6 alkyl optionally substituted by hydroxy, —OR 6 , or —NR 6 R 6 .