Patent ID: 7728144

Claim:
A compound of formula I: wherein: a is 0 or an integer of from 1 to 5; each R 1 is independently selected from —C 1-5 alkyl, —C 2-5 alkenyl, —C 2-5 alkynyl, —C 3-6 cycloalkyl, -cyano, -halo, —OR 1a , —C(O)OR 1b , —SR 1c , —S(O)R 1d , —S(O) 2 R 1e , —NR 1f R 1g , —NR 1h S(O) 2 R 1i , and —NR 1j C(O)R 1k ; where each of R 1a-1k is independently —H, —C 1-5 alkyl or phenyl-C 1-5 alkyl; b is 0 or an integer of from 1 to 4; each R 2 is independently selected from —C 1-5 alkyl, —C 2-5 alkenyl, —C 2-5 alkynyl, —C 3-6 cycloalkyl, -cyano, -halo, —OR 2a , —C(O)OR 2b , —SR 2c , —S(O)R 2d , —S(O) 2 R 2e , —NR 2f R 2g , —NR 2h S(O) 2 R 2i , and —NR 2j C(O)R 2k ; where each of R 2a-2k is independently —H, —C 1-5 alkyl or -phenyl-C 1-5 alkyl; W is —O— or —NW a —, where W a is —H or —C 1-5 alkyl; c is 0 or an integer from 1 to 5; each R 3 independently is —C 1-5 alkyl or two R 3 groups are joined to form C 1-3 alkylene, C 2-3 alkenylene or oxiran-2,3-diyl; m is 0 or 1; Z is selected from —C(O)N(R 4 )— and —N(R 4 )C(O)—, where R 4 is selected from —H, —C 1-5 alkyl, and —C 3-5 cycloalkyl; s is 0, 1 or 2; Ar is a phenylene substituted with (R 5 ) q where q is 0 or an integer from 1 to 4 and each R 5 is independently selected from -halo, —OH, —C 1-5 alkyl, and —C 1-5 alkoxy; t is 0, 1 or 2; R 6 is selected from —H, —C 1-5 alkyl, and —X 6 R 6a ; where X 6 is —C 1-5 alkylene and R 6a is selected from —OH, —C 1-5 alkoxy and -heteroaryl; and R 7 is selected from —H, —C 1-5 alkyl, —C 3-6 cycloalkyl, and —X 7 R 7a ; where X 7 is selected from —C 1-5 alkylene, —C(O)—, —C 1-5 alkylene-C(O)—, —S(O 2 )—, —C 1-5 alkylene-S(O 2 )—, and —S(O 2 )—C 1-5 alkylene; and R 7a is selected from —OH, —C 1-5 alkyl, —C 3-6 cycloalkyl, —C 1-5 alkoxy, heteroaryl, —NR 7b R 7c , where R 7b and R 7c are independently —H or —C 1-5 alkyl wherein each alkyl and alkoxy group in R 1 , R 1a-1k , R 2 , R 2a-2k , R 3 , R 5 , R 6 , R 7 , and R 7a-c is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.