Patent ID: 7456195

Claim:
A compound of Formula (III): or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: W is X 1 is CH or N; R 1 is Cl, Br, Me, Et, OMe, OEt, OCHF 2 , or cyclopropyl; R 2 is H, F, Cl, OMe, O(i-Pr), or OCHF 2 ; R 3 is H or OMe; R 4 is H, F, Cl, or OMe; R 7 is H, Me, —CH 2 CO 2 H, or —CH 2 CO 2 (C 1-4 alkyl); R 8 is H, Me, CO 2 H, CO 2 (C 1-4 alkyl), —CH 2 CO 2 H, or —CH 2 CO 2 (C 1-4 alkyl); R 10a is F, O(C 1-4 alkyl), CONR c R d , —S(C 1-4 alkyl), —SO 2 (C 1-4 alkyl), —SO 2 -cyclopropyl, —SO 2 -cyclobutyl, —SO 2 -cyclopentyl, —SO 2 -(pyrrolidin-1-yl), —SO 2 -(piperid-1-yl), —SO 2 -(azepan-1-yl), —SO 2 NR c R d , —SO 2 NH-cyclopropyl, morpholin-4-yl, 3,5-dimethyl-pyrazol-1-yl, or 3,5-diethyl-pyrazol-1-yl; R 10b is OH, NH 2 , —NHCO(C 1-4 alkyl), —NHCO 2 (C 1-4 alkyl), —NHSO 2 NH 2 , —SO 2 NH 2 , or —NHCONR c R d ; R 10c is H, Cl, or Me; R c and R d are, independently at each occurrence, H or C 1-4 alkyl; alternatively, R c and R d , when attached to the same nitrogen atom, combine to form a 4- to 5-membered heterocycle comprising: carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O) p ; wherein said heterocycle is substituted with 0-2 R g ; and R g is, independently at each occurrence, ═O, F, Cl, Br, CF 3 , OH, or C 1-4 alkyl.