Patent ID: 8835412

Claim:
A compound of formula (I): wherein R 1 is (CH 2 ) n —Z—(CH 2 ) n′ —R 4 n is 0, 1 or 2; n′ is 0, 1 or 2; Z is a single bond or is selected from the group consisting of —S—, —O—, —C(O)—, and —NR 3 ; R 3 is selected from the group consisting of H, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 8 )cycloalkyl, aryl, aryl(C 1 -C 6 )alkyl, and heteroaryl, which are optionally substituted by —CN; R 4 is selected from the group consisting of: H, halogen, —OH, —SH, —CN, and —NR 6 R 7 ; aryl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkylcarbonyl, (C 1 -C 6 )alkylcarboxyl, HO(C 1 -C 6 )alkylcarboxyl, (C 1 -C 6 )alkylamide, and (C 1 -C 6 )alkoxy, which are optionally substituted by one or more oxo groups; (C 1 -C 6 )alkyl which may be optionally substituted by one or more substituents selected from the group consisting of a halogen atom, —CN, —OH, —NH 2 , —NO 2 , —CF 3 , and —SH; (C 2 -C 6 )alkynyl; (C 5 -C 17 )alkenylcarbonyl; and a mono-, bi-, or tricyclic saturated or partially unsaturated or unsaturated ring, optionally substituted by one or more halogen atoms or oxo groups; R 6 and R 7 are independently selected from the group consisting of H, (C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy; X and Y are independently H or halogen atoms; R 2 is selected from the group consisting of: —(CH 2 ) s —K-A-(CH 2 ) t —W, —(CH 2 ) s —K—(CH 2 ) t —B—W, and —(CH 2 ) s —(CHR 5 )—W; s is 0 or 1; t is 0 or 1; K is selected from the group consisting of a group —CH═CH—, arylene, and heteroarylene, where such arylene and heteroarylene groups may be optionally substituted by one or more groups independently selected from: halogen, (C 1 -C 6 )alkyl, —OH, (C 1 -C 6 )alkoxy, and (C 1 -C 6 )haloalkyl; A is selected from the group consisting of a bond, —O—, and —S—; B is selected from the group consisting of a bond, —O—, and —S—; W is aryl or heteroaryl, where such aryl and heteroaryl groups may be optionally substituted by one or more groups independently selected from: halogen, —OH, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, and (C 1 -C 6 )haloalkyl; R 5 is aryl or heteroaryl, where such aryl and heteroaryl groups may be optionally substituted by one or more groups independently selected from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, —OH, and (C 1 -C 6 )haloalkyl; or a pharmaceutically acceptable salt thereof; with the proviso that when s is 1, K is optionally substituted heteroarylene, t is zero, and A or B is a bond, then W is optionally substituted heteroaryl.