Patent ID: 7279474

Claim:
A compound of formula (I) and stereoisomers, prodrugs and pharmaceutically acceptable salts thereof wherein R is aryl or heteroaryl, each of which may be substituted by 1 to 4 groups selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, —COR 4 , nitro, —NR 9 R 10 cyano, and a group R 5 ; R 1 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy, halogen, NR 9 R 10 or cyano; R 2 and R 3 together with N form a saturated or unsaturated heterocycle, which may be substituted by 1 to 3 R 7 groups; or R 2 and R 3 together with N form a 5-10 membered heteroaryl group, in which the 5-membered heteroaryl group contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6-10 membered heteroaryl group contains from 1 to 3 nitrogen atoms and wherein said 5-10 membered heteroaryl may be substituted by 1 to 3 R 7 groups; R 4 is a C1-C4 alkyl, —OR 9 or —NR 9 R 10 ; R 5 is a 5-6 membered heterocycle, which may be saturated or may contain one to three double bonds, and which may be substituted by 1 or more R 8 groups; R 6 is a C1-C6 alkyl that may be substituted by one or more groups selected from: C3-C7 cycloalkyl, C1-C6 alkoxy, haloC1-C6 alkoxy, hydroxy, and haloC1-C6 alkyl; R 7 is a group R 5 , a group R 6 , C3-C7 cycloalkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, C(O)NR 9 R 10 , or phenyl which may be substituted by 1 to 4 R 8 groups; R 8 is C1-C6 alkyl, halo C1-C2 alkyl, halogen, nitro, C1-C6 alkoxy or cyano; R 9 is hydrogen or C1-C6 alkyl; R 10 is hydrogen or C1-C6 alkyl; X is nitrogen; and n is 1.