Patent ID: 8304581

Claim:
A method of enantioselective addition to enones, comprising: reacting R 3 (CH 2 ) p CH═CR 5 C(═O)Y(CH 2 ) q R 4 with R 6 ZnR 7 in the presence of a compound represented by the following formula (I) and a transition metal catalyst, wherein R 1 and R 2 taken together is (CH 2 ) m X(CH 2 ) n ; each of R 3 and R 4 , independently, is alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl, or R 3 and R 4 taken together is alkylene, alkenylene, cycloalkylene, cycloalkenylene, heterocycloalkylene, heterocycloalkenylene, arylene, or heteroarylene; R 5 is hydrogen, halogen, nitro, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl; each of R 6 and R 7 , independently, is alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl; X is O, S, or CH 2 ; Y is O, S, or a bond; each of p and q, independently, is an integer of 0 to 30; and each of m and n, independently, is 1, 2 or 3, and the sum of m and n is 3 or 4.