Patent ID: 7754646

Claim:
A reagent for solid phase synthesis consisting essentially of porous organosilica spherical particles having: i) interior and exterior surfaces; ii) diameters between approximately 0.08 microns and 200 microns; iii) a mean exterior, interior, or total surface area of at least approximately 5 square meters per gram of dry weight; iv) a high level of reactive functionalized groups on the particle exterior surfaces; wherein the pores of said particles non-uniform in diameter and are linked by channels, and wherein the interior surfaces are capable of binding molecules, wherein said porous organosilica spherical particles are formed by the process of: a) forming a mixture of acid, water, and a silane or silane derivative monomer, wherein said silane or silane derivative monomer is selected from the group consisting of an X-Y trimethoxy- or triethoxysilane, wherein X is a moiety selected from the group consisting of a thiol, a chlorine, or an isothiocyanate, and Y is a carbon chain selected from the group consisting of ethyl, propyl, butyl, pentyl, hexyl, and heptyl; b) during or after said forming of said mixture, exposing said mixture to a non-surfactant catalyst for cross-linking, wherein said cross-linking occurs to form said organosilica spherical particles in the absence of added surfactant.