Patent ID: 7078403

Claim:
A compound of formula I Het-A-Alk-W-Ar-C(X 2 )═NO-X 1 I, or a salt or pharmaceutically acceptable derivative thereof, where: Het is a radical of the formula: wherein each R 1 is independently selected from the group consisting of hydrogen, di(C 1-6 alkylamino, cyano, formyl, C 1-6 alkoxy, hydroxyC 1-4 alkyl, C 1-4 alkoxyC 1-4 alkyl, C 1-6 haloalkoxy, aryloxy, C 1-6 -alkylthio, arylthio, C 1-6 alkylsulphinyl, C 1-6 alkylsulphonyl, arylsulphinyl, arylsulphonyl, —CH═NO-C 1-4 alkyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyl and aryl; R 2 and R 3 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 alkoxy and halo; or R 1 and R 2 or R 2 and R 3 combined in radicals (a-1), (a-4), (a-7) and (a-13) may represent a bivalent radical of formula —CH═CH—CH═CH— or (CH 2 ), where p is an integer from 2 to 4; each Y is independently O or S; and each Y′ is O, SO or SO 2 : A is O, S, NH, N(C 1-6 alkyl), CH 2 O, a direct bond or a bivalent heterocyclic radical of the formula: where one or more of the carbon atoms within the radicals (b-1) to (b-4) may be optionally substituted with C 1-6 alkyl or two carbon atoms in the radicals (b-1) to (b-4) may be bridged with a divalent C 2-4 alkyl radical, m and n are each independently integers of 1 to 4 inclusive with the proviso that the sum of m and n in radicals (b-1) to (b-4) is 3, 4 or 5; Z is N or CR 6 where R 6 is hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy or amino; Z′ is O, S, CHR 7 or NR 8 where R 7 is hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy or amino and R 8 is hydrogen or C 1-6 alkyl; R 4 is hydrogen or C 1-6 alkyl; and R 5 is hydrogen, hydroxy, C 1-6 alkyl or C 1-6 alkoxy; Alk is divalent C 1-7 alkyl or a direct bond; W is O, S, OCH 2 , a direct bond or NR 9 where R 9 is hydrogen or C 1-6 alkyl; Ar is a radical of the formula: where each Y is independently O or S, and R 10 and R 11 are each independently hydrogen, C 1-6 alkyl, hydroxy, C 1-6 alkyl, halo, amino, cyano, nitro, C 1-6 alkoxy, hydroxy C 1-6 alkylthio, or trifluoromethyl; X 1 is C 1-6 alkyl, C 3-6 alkenyl, C 3-6 haloalkenyl, C 3-6 alkynyl, C 3-6 haloalkynyl or C 1-6 alkyl substituted by halo, cyano, nitro, hydroxy, aryl, C 1-4 alkoxy, C 2-6 alkoxyalkoxy, acyl or C 1-4 alkylthio; and X 2 is hydrogen, cyano, F, Cl, C 1-4 alkyl, C 1-4 haloalkyl or a bivalent radical of formula —CH 2 ) 2 —, —(CH 2 ) 3 —, —CH 2 ) 2 O— or —(CH 2 ) 2 O— which forms a 5- or 6-membered ring with a neighbouring carbon atom of Ar; with the proviso that when Alk is a direct bond and A is O, S, CH 2 O or a direct bond, then W is not O, S, OCH 2 or a direct bond.