Patent ID: 8846866

Claim:
A non-naturally occurring, recombinant polypeptide comprising a heterologous sulfatase motif having a 2-formylglycine residue, wherein the heterologous sulfatase motif is less than 13 amino acid residues and contain a contiguous sequence of the formula: X 1 (FGly)X 2 Z 2 X 3 R where FGly is a 2-formylglycine residue; Z 2 is a proline or alanine residue; X 1 is present or absent and, when present, is any amino acid, with the proviso that when the heterologous sulfatase motif is at an N-terminus of the aldehyde tagged polypeptide, X 1 is present; and X 2 and X 3 are each independently any amino acid, wherein the heterologous sulfatase motif does not include a threonine-glycine-arginine (TGR) motif C-terminal to the arginine residue of the heterologous sulfatase motif.