Patent ID: 8728438

Claim:
A method of induction of immunosuppression following transplantation comprising administering an effective amount of a coronin 1 modulator for immunosuppression to a patient having a transplant, wherein the coronin 1 modulator is selected from the group consisting of: an anti-coronin 1 polyclonal antibody, monoclonal antibody or an Fab fragment thereof; a humanized antibody comprising the binding portion of an anti-coronin 1 monoclonal antibody; a peptide comprising a coronin 1 peptide selected from (SEQ ID NO: 1) KSRELRVNRGLDTGRRR, (SEQ ID NO: 2) VSRLEEEMRKLQATVQELQKRLDRLEETVQAK, (SEQ ID NO: 3) MSRQVVRSSKFRHVFGQPAKADQCYE, (SEQ ID NO: 4) VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWE, (SEQ ID NO: 5) LEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWD, (SEQ ID NO: 6) PEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIE, (SEQ ID NO: 7) DRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWD, and (SEQ ID NO: 8) PLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYF; a phospho-peptide comprising a peptide of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, or 8, wherein one to five serine and/or threonine residues are phosphorylated; and an RNA selected from (SEQ ID NO: 9) GUUCCGCCACGUGUUUGGA, (SEQ ID NO: 10) UCCAAACACGUGGCGGAAC, (SEQ ID NO: 11) GGCCGACCAGUGCUAUGAA, (SEQ ID NO: 12) UUCAUAGCACUGGUCGGCC, (SEQ ID NO: 13) GAUGUGCGCGUCUCACAGA, (SEQ ID NO: 14) UCUGUGAGACGCGCACAUC, (SEQ ID NO: 15) CCCUAAGUUUGUGGCCCUG, (SEQ ID NO: 16) CAGGGCCACAAACUUAGGG, (SEQ ID NO: 17) GUUUGUGGCCCUGAUCUGU, and (SEQ ID NO: 18) ACAGAUCAGGGCCACAAAC.