Patent ID: 8367359

Claim:
A method for screening a subject for insulin resistance, diabetes, diabetes risk, pre-diabetes, or diseases involving altered insulin activity comprising: a. obtaining a plasma, tissue, or biofluid sample from the subject, b. determining relative or absolute abundance of a metabolite or metabolites present in the sample by performing gas chromatogram mass spectrometric analysis on the sample for the presence or absence of metabolites, wherein a scan of the mass range is 40-500 Da, c. comparing the peak areas or heights found in the scan to differential peak areas or heights of the metabolites 3 hydroxybutanoic acid, oleic acid, gluconic acid, fructose, palmitoleic acid, (3,6) andhydrogalactose, glucuronic acid, sucrose, glucose, heptadecanoic acid, inulobiose 2, leucine, 2-hydroxybutanoic acid, 2-deoxyerythritol, linoleic acid, palmitic acid, phosphoethanolamine, uridine, 2-ketoisocaproic acid, xylose, cystine, histidine, serine, valine, leucine, isoleucine, stearic acid, tyrosine, lysine, ethanolamine, arachidonic acid, glycerol-alpha-phosphate, putrescine, lactic acid 206604, 228939, 223513, 225539, 226851, 210286, 199794, 228143, 199777, 270003, 241310, 213143, 208655, 212208, 227352, 226853, 281329, 213193, 223505, 228315, 222049, 228147, 228911, 281216, 281257, 225555, 231713, 213304, 227367, 236890, 223402, 281229, 223506 found in subjects with insulin resistance, diabetes or pre-diabetic conditions.