Patent ID: 7179804

Claim:
A compound of Formula I: wherein: D 1 is a C 1 –C 3 alkane-diyl; D 2 is CH or nitrogen; D 4 is oxygen or sulffir; R 1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R 4 is a radical selected from the group consisting of: wherein A 1 , A 2 , A 3 , and A 4 , together with the atoms to which they are attached, form an unsaturated heterocyclic ring in which each of A 1 , A 2 , and A 3 is independently CR 7 , nitrogen, which nitrogen is optionally substituted with R 8 , oxygen, or sulfur, and A 4 is carbon or nitrogen, wherein only one of A 1 , A 2 , and A 3 can be oxygen or sulfur; A 5 , A 6 , A 7 , and A 8 , together with the atoms to which they are attached, form an unsaturated carbocyclic or heterocyclic ring in which each of A 5 , A 6 , A 7 , and A 8 is independently CR 7 or nitrogen, wherein at least one of A 5 , A 6 , A 7 , and A 8 must be CR 7 ; each R 7 is independently selected from the group consisting of hydrogen, halo, C 1 –C 4 alkyl, substituted C 1 –C 4 alkyl, C 3 –C 6 cycloalkyl, C 1 –C 4 alkoxycarbonyl, trifluoromethyl, trifluoromethoxy, and —NR 9 R 10 ; R 9 and R 10 are each independently hydrogen, C 1 –C 4 alkyl, or —C(O)—CH 3 , or R 9 and R 10 , together with the nitrogen to which they are attached, form a 4–7 membered saturated heterocyclic ring; each R 8 is independently selected from the group consisting of hydrogen, C 1 –C 4 alkyl, substituted C 1 –C 4 alkyl, and C 1 –C 3 cycloalkyl; R 6 is C 1 –C 4 alkyl, C 3 –C 6 cycloalkyl, phenyl, or pyridyl, which phenyl or pyridyl is optionally substituted with one to three substituents independently selected from the group consisting of halo, cyano, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, trifluoromethyl, trifluoromethoxy, and —NR 11 R 12 ; R 11 and R 12 are each independently hydrogen or C 1 –C 4 alkyl, or R 11 and R 12 , together with the nitrogen to which they are attached, form a 4–7 membered saturated heterocyclic ring; R 5 is hydrogen, halo, trifluoromethyl, C 1 –C 4 alkyl, C 3 –C 6 cycloalkyl, furyl, thienyl, pyrrolyl, imidazolyl, —NR 13 R 14 , pyridyloxy, phenyl, phenoxy, phenylthio, anilino, which phenyl, phenoxy, phenylthio, or anilino group may be optionally substituted on the phenyl ring with one or two substituents independently selected from the group consisting of halo, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, and —S(O) q (C 1 –C 4 alkyl), or a radical selected from the group consisting of: wherein W is a bond, CHR 15 , O, NR 15 , or S(O) q ; q is 0, 1, or 2; R 15 is selected from the group consisting of hydrogen, C 1 –C 4 alkyl, acetyl, carbamoyl, phenyl, benzyl, and —S(O) 2 CH 3 ; Z 1 , Z 2 , and Z 3 are each independently CH or nitrogen; R 13 and R 14 are each independently hydrogen or C 1 –C 4 alkyl; or a pharmaceutically acceptable salt thereof.