Patent ID: 8628936

Claim:
A method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject, wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: (i) the structural composition of a polypeptide in said sample; (ii) a metabolite in said sample; and (iii) a catalytic activity in said sample, wherein the at least two characteristics comprise: (i) a structural composition of a polypeptide in said sample and at least one further characteristic selected from (ii) and (iii) wherein each of said at least two characteristics is determined from a multiplexed analysis of the same sample and wherein assaying the structural composition of a polypeptide comprises: (a) adding a peptidase to said sample to generate peptide fragments (b) analyzing the polypeptide fragments of the polypeptides in said sample after peptidase treatment (c) inferring from (b) information regarding the structural composition of said polypeptide.