Patent ID: 7452874

Claim:
A compound represented by the following Formula: wherein: R, R 1 , R 2 and R 3 are each independently selected from hydrogen, C 1-6 alkyl, —(CH 2 ) p OR 4 , —C(O)OR 4 , formyl, nitro, cyano, halogen, aryl, aryl substituted by one or more substituents selected from the group consisting of: —CO 2 R 22 , aryl, —C(O)NHS(O) 2 R 20 , —NHS(O) 2 R 20 , hydroxyalkyl, alkoxy, —C(O)NR 21 R 22 , acyloxy, alkyl, amino, N-acylamino, hydroxy, —(CH 2 ) g C(O)OR 8 , —S(O) n R 8 , nitro, tetrazole, cyano, halogen, trifluoromethyl, protected —OH and a heterocyclic methylene substituent as represented by Formula (III), where g is 0-6; R 8 is hydrogen or alkyl; R 20 is selected from hydrogen, C 1 -C 4 alkyl, aryl and trifluoromethyl; R 21 and R 22 are independently selected from hydrogen, C 1 -C 4 alkyl, aryl and trifluoromethyl; V, W, X and Z are each independently selected from O, S, and NR 16 , where R 16 is selected from: hydrogen, alkyl, cycloalkyl, C 1 -C 12 aryl, substituted alkyl, substituted cycloalkyl and substituted C 1 -C 12 aryl; and n is 0-2. substituted alkyl, —S(O) n R 4 , cycloalkyl, —NR 5 R 6 , protected —OH, —CONR 5 R 6 , phosphonic acid, sulfonic acid, phosphinic acid, —SO 2 NR 5 R 6 , and a heterocyclic methylene substituent as represented by Formula (III), where p is 0-6, n is 0-2, V, W, X and Z are each independently selected from O, S, and NR 16 , where R 16 is selected from: hydrogen, alkyl, cycloalkyl, C 1 -C 12 aryl, substituted alkyl, substituted cycloalkyl and substituted C 1 -C 12 aryl, R 4 is hydrogen, alkyl, cycloalkyl, C 1 -C 12 aryl, substituted alkyl, substituted cycloalkyl and substituted C 1 -C 12 aryl, and R 5 and R 6 are each independently selected from hydrogen, alkyl, substituted alkyl, C 3-6 cycloalkyl, and aryl, or R 5 and R 6 taken together with the nitrogen to which they are attached represent a 5 to 6 member saturated ring containing up to one other heteroatom selected from oxygen and nitrogen; R 15 is selected from the group consisting of alkyl, C 1 -C 12 aryl, alkoxy, substituted alkyl, substituted C 1 -C 12 aryl and halogen; m is 0-6; and Y is selected from alkyl, substituted alkyl and a cyclic or polycyclic aromatic ring containing from 3 to 14 carbon atoms and optionally containing from one to three heteroatoms, provided that when the number of carbon atoms is 3, the aromatic ring contains at least two heteroatoms and when the number of carbon atoms is 4, the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of: alkyl, substituted alkyl, C 1 -C 12 aryl, substituted cycloalkyl, substituted C 1 -C 12 aryl, hydroxy, aryloxy, alkoxy, cycloalkyl, nitro, cyano, halogen and protected —OH; or a pharmaceutically acceptable salt thereof; provided that at least one of R, R 1 , R 2 and R 3 is a substituted aryl group or a heterocyclic methylene substituent as represented in Formula (III).