Patent ID: 7875607

Claim:
A method of treating a subject suffering from neurodegenerative or neuroinflammatory disorders, comprising administering to said subject a therapeutically effective amount of a compound represented by Formula I: wherein: -A-B— is —CH 2 —(CH 2 ) 0-2 —; —CH—CH—; —CH 2 —O—; —CH 2 —S—; or CH 2 —N—; n is 0 to 5; V is C 7-12 -bicyclo[a.b.c]alkyl; C 7-12 -bicyclo[a.b.c]alkenyl; C 7-12 -heterobicyclo[a.b.c]alkyl; or C 7-12 -heterobicyclo[a.b.c]alkenyl; and a, b, and c are 0 to 6; and wherein the bicyclo ring is optionally substituted with one or more substituents selected from C 1-6 -alkyl, halogen, haloalkyl, carboxy, alkoxycarbonyl, cyano, hydroxy, alkoxy, thiol, and oxo; R 1 is C 1-6 alkyl; R 2 is C 1-20 alkyl; optionally substituted C 2-20 alkenyl; halogen; hydroxy; alkoxy; acyl; —C(O)OR; —S(O) 2 OR; —NR′R″; —NH—C(═NH 2 )—NR′R″; N—SO 2 R; —NHC(O)NR′R″; —N(OH)C(O)NR′R″; —SO 2 NR′R″; —C(O)NR′R″; —S(O) 0-3 R′″; —PO(OR) 2 ; triphenylphosphonium; trialkylphosphonium; optionally substituted aryl; or optionally substituted heterocyclyl; R 3 is hydrogen; optionally substituted C 1-20 alkyl; C 2-20 alkenyl; hydroxyalkyl; acyl; glucoside; phosphoryl; phosphoryloxyalkyl; carboxyalkylcarbonyl; aminoalkylcarbonyl; or alkylketocarbonyl; R 4 is hydrogen; halogen; nitro, cyano; optionally substituted C 1-6 alkyl; aryl, arakyl, heterocyclyl or heterocyclylalkyl all optionally substituted with alkyl, hydroxy, alkoxy, nitro, acyl, amino, oxo or —C(O)OR; optionally substituted alkenyl; hydroxy, alkoxy, nitro; —C(O)OR; —C(O)NR′R″; —NR′R″; —NHC(O)NR′R″; —NR′—SO 2 —R; —NH—C(═NH 2 )—NR′R″; —SO 2 NR′R″; or —P(O)(OR) 2 ; or R 3 and R 4 taken together with the atoms to which they are attached form a heterocyclic ring; R is hydrogen; optionally substituted alkyl; optionally substituted aryl; optionally substituted arylalkyl; optionally substituted cycloalkyl; or optionally substituted heterocyclyl; R′ and R″ are independently of each other hydrogen; C 1-6 alkyl; hydroxyalkyl; aminoalkyl; optionally substituted aryl; or optionally substituted benzyl; or R′ and R″ taken together with the atom to which they are attached form a 5 to 8 membered aromatic, saturated or unsaturated ring, optionally incorporating one additional atom chosen from N, O, or S and optionally substituted with a substituent selected from the group consisting of C 1-6 alkyl, halo, cyano, alkylthio, lower alkoxy, phenyl, benzyl and carboxy; and R′″ is optionally substituted C 1-6 alkyl; optionally substituted aryl; or optionally substituted heterocyclyl; or stereoisomers, mixture of stereoisomers or pharmaceutically acceptable salts thereof.