Patent ID: 7495014

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W is selected from CH or CF; X is selected from CH or CF; Z is O or NH; R 1 is phenyl or a 5-6 membered heteroaryl ring having 1-3-heteroatoms independently selected from oxygen, nitrogen, or sulfur, wherein: R 1 is substituted with 0-3 groups independently selected from -(T) y -Ar, R′, oxo, C(O)R′, CO 2 R′, OR′, N(R′) 2 , SR′, NO 2 , halogen, CN, C(O)N(R′) 2 , NR′C(O)R′, SO 2 R′, SO 2 N(R′) 2 , or NR′SO 2 R′; y is 0 or 1; T is a straight or branched C 1-4 alkylidene chain, wherein one methylene unit of T is optionally replaced by —O—, —NH—, or —S—; each R′ is independently selected from hydrogen, C 1-4 aliphatic, or a 5-6 membered saturated, unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: R′ is substituted with 0-3 groups independently selected from halogen, oxo, R o , N(R o ) 2 , OR o , CO 2 R o , NR o C(O)R o , C(O)N(R o ) 2 , SO 2 , R o , SO 2 N(R o ) 2 , or NR o SO 2 R o , wherein: each R o is independently selected from hydrogen, C 1-4 aliphatic, or a 5-6 membered saturated, unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein: two substituents on adjacent positions of R 1 may be taken together to form a 5-7 membered saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Ar is a 3-8 membered saturated, unsaturated, or aryl ring, a 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein: Ar is substituted with 0-3 groups independently selected from R′, oxo, CO 2 R′, OR′, N(R′) 2 , SR′, NO 2 , halogen, CN, C(O)N(R′) 2 , NR′C(O)R′, SO 2 R′, C(O)R′, SO 2 N(R′) 2 , or NR′SO 2 R′; R 2 is selected from hydrogen or a C 1-3 aliphatic group; and Ring A is a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, provided that said ring has a hydrogen-bond acceptor in the position adjacent to the point of attachment to Ring B, wherein: Ring A is substituted with 0-3 groups independently selected from R′, oxo, CO 2 R′, OR′, N(R′) 2 , SR′, NO 2 , halogen, CN, C(O)N(R′) 2 , NR′C(O)R′, SO 2 R′, SO 2 N(R′) 2 , or NR′SO 2 R′, and wherein: two substituents on adjacent positions of Ring A may be taken together to form a 5-7 membered saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur.