Patent ID: 7767854

Claim:
A N-substituted phenylacetamide derivative of the formula (I): wherein R 1 is a methoxy group, a hydroxyl group, or a hydrogen atom; R 2 is a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkylcarbonyl group, or an arylcarbonyl group; and D is a group of the following formula (A), (B), or (C): wherein R 3 is defined as a group of —X—Y—Z, wherein X is a single bond, a C 1-10 alkylene group, a C 2-10 alkenylene group or a C 2-10 alkynylene group; Y is a single bond, —O—, —O—C(═O)—, or —C(═O)—O—; Z is a straight or branched hydrocarbon group selected from the group consisting of a C 1-10 alkyl group, a C 2-10 alkenyl group, a C 2-10 alkynyl group, and a C 4-10 alkenyl-alkynyl group, in which the hydrocarbon may be optionally substituted with a C 3-8 cycloalkyl or an aryl; or a cyclic group selected from the group consisting of a C 3-8 cycloalkyl group, a C 3-8 cycloalkylidene-C 1-3 alkyl group, and an aryl group; the alkylene group, the alkenylene group, the alkynylene group, the alkyl group, the alkenyl group, the alkynyl group, and the alkenylalkynyl group in the above X and Z may be optionally substituted with 1-5 substituents selected from the group consisting of fluorine atoms and hydroxyl groups; the cycloalkyl group and the cycloalkyl moiety in the above Z may be optionally substituted with 1-5 substituents selected from the group consisting of fluorine atoms, hydroxyl groups, and C 1-6 alkyl groups; the aryl group and the aryl moiety in the above Z may be optionally substituted with 1-5 substituents selected from the group consisting of fluorine atoms, hydroxyl groups, C 1-6 alkyl groups optionally substituted with 1-5 fluorine atoms, C 1-6 alkoxy groups optionally substituted with 1-5 fluorine atoms, nitro groups, amino groups, cyano groups, C 1-4 alkyloxycarbonyl groups, C 1-4 alkylcarbonyloxy groups, carboxyl groups, and methylenedioxy groups; provided that X is a single bond and Z is not an aryl group when Y is a single bond; both X and Y are a single bond when Z is a C 3-8 cycloalkylidene-C 1-3 alkyl group; or X is a C 1-10 alkylene group when Y in the formula (B) or (C) is —O—; R 4 is a hydrogen atom, a hydroxyl group, a C 1-4 alkyl group, a C 2-4 alkenyl group, or a C 2-4 alkynyl group, provided that R 4 in formula (C) is not a hydroxyl group; alternatively R 3 and R 4 are taken together to form a C 3-8 cycloalkyl group or a saturated C 3-8 heteromonocyclyl group containing 1 or 2 oxygen atoms, each of which may be optionally substituted with 1-5 C 1-6 alkyl groups; further provided that R 3 and R 4 in formula (A) contain at least 3 carbon atoms in total; R 3 in formula (B) contains at least 3 carbon atoms; and R 3 and R 4 in formula (C) contain at least 2 carbon atoms in total, or a physiologically acceptable salt thereof.