Patent ID: 7638323

Claim:
A method of producing a mucin-immunoglobulin fusion polypeptide comprising: a) providing a cell comprising: i) a nucleic acid encoding a mucin polypeptide linked to a nucleic acid encoding at least a region of an immunoglobulin polypeptide; ii) a nucleic acid encoding an α1,3 galactosyltransferase polypeptide; and iii) a nucleic acid encoding a β 1,6,-N-acetylglucosaminyltransferase polypeptide; b) culturing the cell under conditions that permit production of said mucin-immunoglobulin fusion polypeptide wherein said fusion polypeptide is glycosylated by said α1,3 galactosyltransferase and said β 1,6,-N-acetylglucosaminyltransferase; and c) isolating said mucin-immunoglobulin fusion polypeptide.