Patent ID: 7928239

Claim:
A compound of Formula I A-D-B (I) or a pharmaceutically acceptable salt thereof, wherein: D is —NH—C(O)—NH—, A is of the formula: -L-(M-L 1 ) q , where L is substituted or unsubstituted phenyl bound directly to D, L 1 is phenyl substituted by —C(O)R x , or pyridinyl substituted by —C(O)R x , M is oxygen, q is 1 and B is a substituted or unsubstituted pyridyl group, a substituted or unsubstituted quinolinyl group or a substituted or unsubstituted isoquinolinyl group, where B is substituted, L is substituted or L 1 is additionally substituted, the substituents are selected from the group consisting of halogen, up to per-halo, and Wn, where n is 0-3; R x , is NR a R b where R a and R b are, a) independently hydrogen, C 1 -C 10 alkyl, C 3-10 cycloalkyl, C 2-10 alkenyl, C 1-10 alkenoyl, phenyl, pyridinyl, piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, tetrahydrofuryl, substituted C 1-10 alkyl, substituted C 3-10 cycloalkyl, substituted phenyl, substituted pyridinyl, substituted piperazinyl, substituted morpholinyl, substituted piperidinyl, substituted pyrrolidinyl, or substituted tetrahydrofuryl, where R a and R b are a substituted group, they are substituted by halogen up to per halo, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, C 3-10 cycloalkyl, phenyl, pyridinyl, piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, tetrahydrofuryl, halo-substituted C 1-6 alkyl up to per halo alkyl, halo-substituted phenyl up to per halo phenyl, halo-substituted pyridinyl, up to per halo pyridinyl, halo-substituted morpholinyl, up to per halo morpholinyl, halo-substituted piperidinyl, up to per halo piperidinyl, halo-substituted pyrrolidinyl, up to per halo pyrrolidinyl, or halo-substituted tetrahydrofuryl up to per halo tetrahydrofuryl, each W is independently —CN, —CO 2 R 7 , —C(O)NR 7 R 7 , —C(O)—R 7 , —NO 2 , —OR′, —SR 7 , —NR 7 R 7 , —NR 7 C(O)OR 7 , —NR 7 C(O)R 7 , C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 2 -C 10 alkenyl, C 1 -C 10 alkenoyl, C 3 -C 10 cycloalkyl, phenyl, pyridinyl, pyrazolyl, piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, or tetrahydrofuryl, substituted C 1 -C 10 alkyl, substituted C 1 -C 10 alkoxy, substituted C 2 -C 10 alkenyl, substituted C 1 -C 10 alkenoyl, substituted C 3 -C 10 cycloalkyl substituted phenyl, substituted pyridinyl, substituted pyrazolyl substituted piperazinyl, substituted morpholinyl, substituted piperidinyl, substituted pyrrolidinyl, or substituted tetrahydrofuryl, where W is a substituted group, it is substituted by one or more substituents which are each, independently, —CN, —CO 2 R 7 , —C(O)R 7 , —C(O)NR 7 R 7 , —OR′, —SR', —NR 7 R 7 , —NO 2 , —NR 7 C(O)R 7 , —NR 7 C(O)OR 7 or halogen, each R 7 is independently H, C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 2 -C 10 alkenyl, C 1 -C 10 alkenoyl, C 3 -C 10 cycloalkyl, phenyl or pyridinyl up to per-halosubstituted C 1 -C 10 alkyl, up to per-halosubstituted C 3 -C 10 cycloalkyl or up to per-halo substituted phenyl.