Patent ID: 7045515

Claim:
The compounds have the following general formula (I); wherein, A 1 , A 3 and A 4 are hydrogen atom, halogen atom, alkyl group having one to five carbon atoms, alkoxy group having one to five carbon atoms, —COOR 1 , a following formula (b); wherein, R 1 is hydrogen atom or alkyl group having one to five carbon atoms, or a following formula (a); wherein, R 2 is —CH 2 OH group, —CH 2 OC(O)—R 1 group or —CO 2 —R 1 group, R 3 is —OH group or —OC(O)—R 1 group, R 4 is —(CH 2 ) k R 5 (CH 2 ) 1 — group wherein, 0≦(k+l)≦10, further R 5 means bond which is single bond —, —CH═CH—, —OCH 2 —, carbonyl group or —CH(OH)—, and R 4 connects with tetrahydropyrane ring by carbon-carbon bond, and one of A 1 , A 3 and A 4 in formula (I) is must be the group in above mentioned formula (a), further A 2 is alkylene group having one to five carbon atoms, —O-alkylene having two to five carbon atoms, alkenylene group having two to five carbon atoms, alkylene group substituted by an OH group having two to five carbon atoms or alkylene group substituted by an oxo group having two to five carbon atoms, n, p, q or r are 0, 1 or 2, or their pharmaceutical acceptable salts.