Patent ID: 7687505

Claim:
A method of stimulating proliferation, migration or both proliferation and migration of exogenous neural stem cells or retinal stem cells or both neural and retinal stem cells in vivo, the method comprising administering an effective amount of a pyrimidine derivative of formula (1) or (2), or a pharmaceutically acceptable salt thereof, for an effective period to a mammal that has had more developmentally potent cells administered thereto wherein R1 to R8 independently represent a hydrogen atom, a lower alkyl group, CH 3 OCH 2 CH 2 —, CH 2 CONH 2 , —COCH 3 , —COC 2 H 5 or —CH 2 OCOC 2 H 5 , and X represents NH, N—CH 3 , N—C 2 H 5 , N-ph, N—COOC 2 H 5 , N—SO 2 CH 3 , CH 2 , CHCH 3 , CHC 2 H 5 , —O— or —S— in which ph stands for a phenyl group.