Patent ID: 8338448

Claim:
A compound of formula I: or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or ester thereof, wherein: M is H or -G-L3-Z; E is L 1 , L 2 , and L 3 are each independently selected from the group consisting of a covalent bond, substituted or unsubstituted alkylene, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocycyl, and substituted or unsubstituted heterocyclyl; X, Y and Z are independently H, NR a R b , —OR c , halogen, CF 3 , optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, acyl, carboxy, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted alkyl- or dialkylaminocarbonyl, cyano, optionally substituted heterocyclylacyl, optionally substituted carbocyclylacyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl; R a and R b are each independently selected from the group consisting of H, substituted or unsubstituted alkyl, aldiminyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclylalkyl, and substituted or unsubstituted heterocyclyl; or R a and R b , together with the nitrogen atom to which they are shown attached form a substituted or unsubstituted heterocyclyl; R c is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclylalkyl, Q is N; G is selected from the group consisting of a covalent bond, alkylene, —C(O)—, —C(O)—O—, and —C(O)—NR d —; Rd is selected from the group consisting of H, alkyl, and substituted or substituted arylalkyl; R 3 and R 4 , taken together with the carbon atoms to which they are shown attached, form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl; A and B are each independently one or more substituents selected from the group consisting of H, alkyl, halo, substituted or unsubstituted amino, cyano, nitro, haloalkyl, hydroxyl, and alkoxyl; with the proviso that only one of M, and L 1 X is H.