Patent ID: 7485769

Claim:
A transgenic pig, whose genome comprises a transgene encoding human N-acetylglucosaminyltransferase (GnT III), for providing organs for xenotransplantation comprising: regulatory sequences capable of functioning in the hyperacute rejection-occurring local cells, wherein said regulatory sequences are: (A) a promoter of porcine complement inhibitor and the first intron of a human CD55 gene, or (B) a cytomegalovirus (CMV) enhancer and chicken beta-actin promoter, and said transgene encoding human N-acetylglucosaminyltransferase III (GnT III), wherein said regulatory sequences are operably linked to said transgene encoding human GnT III, and wherein said transgenic pig expresses GnT III in one or more organs selected from the group consisting of: heart, liver, lung, kidney and spleen, and wherein expression of GnT III decreases expression of galactose-α-1,3-galactose antigen in the one or more organs selected from the group consisting of: heart, liver, lung, kidney and spleen, thereby decreasing hyperacute rejection in a human after xenotransplantation of said one or more organs into a human.