Patent ID: 7067529

Claim:
A compound of formula (I): wherein R 1 is -lower alkyl, —CH 2 -aryl, -cycloalkyl, —(CH 2 ) 3 —OC(═O)CH 3 , -lower alcohol, -lower alkyl-R 10 , —CH 2 COOH, or —CH 2 CH 2 OCH 2 CH 3 ; R 2 is -lower alkyl, —CH 2 -aryl, -lower alcohol, —CH 2 C(═O)NH 2 , or -lower alkyl-R 10 , wherein at least one of R 1 or R 2 is —CH 3 ; R 3 is —COOH, -lower alkyl-COOH, -lower alcohol, —CH 2 OCH 3 , —CH 2 NH 2 , —CH 2 NHSO 2 R 11 , —C(═O)R 12 , —CNHCH 2 CH 2 —R 12 , —C(═NH)—R 12 , —(CH 2 ) n NHC(═O)R 13 , —(CH 2 ) m C(═O)N(R 15 )(R 16 ), —C(═NH)—R 17 , or —(CH 2 ) n —R 18 ; R 4 is —H, -lower alkoxy, —O—C(R 7 R 8 )C(═O)R 19 , -halo, —SCH 3 , —C═CHC(═O)—R 10 , —CH 2 CH 2 C(═O)—R 10 , —O-lower alcohol, —OCH 2 CH(OH)CH 2 N═N + N − , —OCH 2 CH 2 OCH 2 CH 2 Cl, —NHC(═O)CH 2 —R 10 , —NHC(═O)CH 2 -lower alkyl, —O(CH 2 ) n -cycloalkyl, —O-lower alkene, or a 5 membered unsaturated heterocyclic ring containing one hetero atom which is S or O; R 5 and R 6 are each independently —H, -halo or -lower alkoxy; R 7 and R 8 are each independently —H or —CH 3 , R 10 is a 5 or 6 membered saturated heterocyclyl containing 1 or 2 heteroatoms, wherein each hetero atom is selected from N and O, and the group is bound to the remainder of the molecule at a ring N; R 11 is —CF 3 , -lower alkyl, —CH 2 Cl, —CH 2 CF 3 , or —R 12 ; R 12 is a 5 or 6 membered saturated substituted or unsubstituted heterocyclic ring containing one hetero atom which is selected from N, O, and S wherein the substituted ring is the heterocyclic ring substituted with —OH or -phenyl; R 13 is -lower alkyl, -lower alkoxy, or —(CH 2 ) n R 14 ; R 14 is a 5 or 6 membered saturated or unsaturated heterocyclic ring containing one or two hetero atoms which are selected from N and O; R 15 is —H or —CH 3 ; R 16 is —H, -lower alkyl, —C≡N, —OH, -lower alkoxy, or —CH 2 COOCH 2 CH 3 ; R 17 is -lower alkoxy —NH 2 or —N-lower alkyl; R 18 is a saturated or unsaturated 5 membered substituted or unsubstituted heterocyclic ring containing from 1 to 4 hetero atoms wherein the hetero atoms are selected from N, O and S, wherein the substituted ring is the heterocyclic ring which is substituted at one or two ring carbons with ═O, or substituted at a ring N with -lower alcohol or -lower alkyl; R 19 is —OH, —NHCH(CH 3 ) 2 , —N(CH 3 )CH 2 -aryl, —N(CH 3 )-lower alkyl, or 5 or 6 membered saturated substituted or an unsubstituted heterocyclyl containing 1 or 2 heteroatoms wherein each heteroatom is independently selected from N, O and S, wherein said substituted heterocyclyl is the heterocyclyl substituted with lower alkyl; m is 0, 1 or 2; n is 0 or 1; and pharmaceutically acceptable salts and esters thereof.