Patent ID: 8703167

Claim:
A medical device comprising a coating, the coating comprising a first layer comprising a hydrophilic drug and a polymer, the polymer having a polar block(s) or a polar segment(s); and a second layer comprising a hydrophobic drug and a hydrophobic polymer; wherein the coating includes the hydrophilic drug and the hydrophobic drug in different layers and provides a concurrent release profile of the hydrophilic drug and the hydrophobic drug; wherein the hydrophilic drug is a cRGD peptide; wherein the hydrophobic drug is sirolimus, everolimus, zotarolimus, or a combination thereof; wherein the polymer with a polar block(s) or segment(s) is selected from the group consisting of polyurethanes, poly(hydroxyethyl methacrylate-block-methyl methacrylate) (poly(HEMA-block-MMA)), poly(hydroxyethyl methacrylate-block-methyl methacrylate) (poly(HEMA-block-HPMA)), poly(hydroxypropyl methacrylate) terminated with glycine-pheylaniline-leucine-glycine (poly(HPMA-GFLG), poly(butyl methacrylate-block-poly(ethylene glycol) acrylate) (poly(BMA-block-PEGA)), poly(methoxyethyl methacrylate-block-hydroxyethyl methacrylate) (poly(MOEMA-block-HEMA)), and combinations of these; and wherein the hydrophobic polymer is a copolymer of MOEMA with PEGA or HEMA having a percentage of PEGA or HEMA below 10 mol %.