Patent ID: 6946468

Claim:
A compound of the formula B: wherein: X is O or H 2 ; e is 0; t is 1 to 4; R 2′ , R 3′ , R 4′ , and R 5′ are independently selected from: H; C 1-8 alkyl, alkenyl, alkynyl, aryl, heterocycle, —CO—NR 6′ R 7′ or —CO—OR 6′ , unsubstituted or substituted with one or more of: 1) aryl or heterocycle, unsubstituted or substituted with: a) C 1-4 alkyl, b) (CH 2 ) t OR 6′ , c) (CH 2 ) t NR 6′ R 7′ , d) halogen, 2) C 3-6 cycloalkyl, 3) OR 6′ , 4) SR 6′ , S(O)R 6′ , SO 2 R 6′ , 5) —NR 6 ′ R 7′ , 6) —NR 6′ —CO—R 7′ , 7) —NR 6′ —CO—NR 7′ R 8′ , 8) —O—CO—NR 6′ R 7′ , 9) —O—CO—OR 6′ , 10) —O—NR 6′ R 7′ , 11) —SO 2 NR 6′ R 7′ , 12) —NR 6′ —SO 2 —R 7′ , 13) —CO—R 6′ , or 14) —CO—OR 6′ ; and any two of R 2′ , R 3′ , R 4′ , and R 5′ are optionally attached to the same carbon atom; Y is aryl, heterocycle, unsubstituted or substituted with one or more of: 1) C 1-4 alkyl, unsubstituted or substituted with: a) C 1-4 alkoxy, b) NR 6′ R 7′ , c) C 3-6 cycloalkyl, d) aryl or heterocycle, e) HO, 2) aryl or heterocycle, 3) halogen, 4) OR 6′ , 5) NR 6′ R 7′ , 6) CN, 7) NO 2 , or 8) CF 3 ; R 6′ , R 7′ and R 8′ are independently selected from: H; C 1-4 alkyl, C 3-6 cycloalkyl, heterocycle, aryl, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, unsubstituted or substituted with: a) C 1-4 alkoxy, b) aryl or heterocycle, c) halogen, d) HO, e) —CO—R 9′ , f) —SO 2 R 9′ , wherein R 6′ and R 7′ may be joined in a ring, and R 7′ and R 8′ may be joined in a ring; R 9′ is C 1-4 alkyl or aralkyl; a pharmaceutically acceptable salt thereof.