Patent ID: 8088770

Claim:
A compound of Formula IV: or a pharmaceutically acceptable salt, and/or ester thereof, wherein: each A is independently aryl or heterocyclyl; Z 1 and Z 2 are each independently —O— or —N(R 7 )—; X and Y are each independently aryl, arylalkyl, heterocyclyl, or heterocyclylalkyl; R 1 , R 3 , and R 5 are each independently selected from the group consisting of H, alkyl, substituted alkyl, arylalkyl, and substituted arylalkyl; each R 7 is independently selected from the group consisting of H, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, and substituted heterocyclyl; R 8 and R 9 are each one or more substituents independently selected from the group consisting of H, alkyl, halogen, aryl, heterocyclyl, and CN; and R 24 is selected from the group consisting of -alkylene-NR 5 —C(O)—R 25 , -alkylene-C(O)—NR 5 —R 26 , -alkylene-N(R 27 ) 2 , —CH 2 -heterocyclyl, and substituted —CH 2 -heterocyclyl; R 25 is alkyl, heterocyclylalkyl, or substituted heterocyclylalkyl; R 26 is a substituted or unsubstituted heterocyclyl; or R 5 and R 26 together with the nitrogen atom to which they are both shown attached, form a substituted or unsubstituted bicyclic heterocyclyl; each R 27 is independently a substituted alkyl which may be the same or different; or each R 27 , together with the nitrogen atom to which they are both shown attached, form a substituted or unsubstituted bicyclic heterocyclyl; with the following provisos: (i) when X and Y are both thiazolylmethyl, Z 1 is —N(R 7 )—, Z 2 is —O—, each A is phenyl, and R 24 is —CH 2 CH 2 —NR 5 —C(O)-alkyl, then each R 8 and R 9 are H; and (ii) when X and Y are both thiazolylmethyl, Z 1 is —N(R 7 )—, Z 2 is —O—, each A is phenyl, and R 24 is —CH 2 —C(O)—NR 5 -pyridyl or —CH 2 —C(O)—NR 5 -pyrrolidinyl, then R 5 is alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl; and (iii) when X and Y are both thiazolylmethyl, Z 1 is —N(R 7 )—, Z 2 is —O—, each A is phenyl, and R 24 is substituted or unsubstituted —CH 2 -heterocyclyl, then said substituted or unsubstituted —CH 2 -heterocyclyl is not pyridylmethyl, pyrazolylmethyl, imidazolidine-2,4-dione-5-yl-methyl, imidazolylmethyl, or morpholinylmethyl.