Patent ID: 7531529

Claim:
A method of treating a genitourinary disease based on mGluR5 receptor mediated disorder wherein said genitourinary disease is a urinary tract disease comprising: administering to a subject in need thereof a therapeutically effective amount of a compound of formula I wherein R 1 is halogen; R 2 is lower alkyl; R 3 is selected from aryl substituted by one, two or three halogen, heteroaryl, and heteroaryl substituted by one, two or three substituents, selected from the group consisting of fluoro, trifluoromethyl, and lower alkyl; and R 4 is selected from the group consisting of hydrogen, C(O)H, and CH 2 R 5 wherein R 5 is selected from the group consisting of hydrogen, OH, C 1 -C 6 -alkyl and C 3 -C 12 -cycloalkyl; or a pharmaceutically acceptable salt thereof.