Patent ID: 8722702

Claim:
A compound of Formula IIa: or a pharmaceutically acceptable salt, a tautomer or a stereoisomer thereof, wherein: A 3 is —CH 2 — or —C(O)—; Q 13 and Q 14 are independently hydrogen, fluoro, chloro, lower alkyl, or fluoro substituted lower alkyl; Q 12 is fluoro, chloro or —CF 3 M 4 is —NHCH 2 — or —NHC(O)—; Q 1a is aryl or heteroaryl, wherein aryl or heteroaryl are optionally substituted with one or more substituents selected from halogen, lower alkyl, fluoro substituted lower alkyl, cycloalkylamino, —NHR 41 , —NR 41 R 41 , —OR 41 or —S(O) 2 R 41 ; and R 41 at each occurrence is independently lower alkyl or cycloalkyl, wherein lower alkyl is optionally substituted with one or more fluoro; Q 5 is —OR 43 , —CN, fluoro, chloro, lower alkyl, fluoro substituted lower alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl or heteroaryl are optionally substituted with one or more substituents selected from halogen, lower alkyl, fluoro substituted lower alkyl, —NHR 43 , —NR 43 R 43 , —OR 43 or —S(O) 2 R 43 , wherein R 43 at each occurrence is independently optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl or optionally substituted heteroaryl.