Patent ID: 7626007

Claim:
A method for inhibiting lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)-dependent induction of tumor necrosis factor-alpha (TNF-α) gene expression in a human cell comprising the steps: a) providing an antisense oligonucleotide that reduces or inhibits expression of the LITAF gene, wherein said antisense oligonucleotide comprises a sequence that is complementary to at least 150 contiguous nucleotides set forth within nucleotides 1-320 of SEQ ID NO: 2 including the start site of translation beginning at nucleotide 234 of SEQ ID NO: 2; and b) delivering the antisense oligonucleotide into said cell; wherein said antisense oligonucleotide reduces or inhibits LITAF-dependent TNF-α gene expression in said cell.