Patent ID: 7834049

Claim:
A method for treating or improving a disease against which an integrin expression inhibition is effective, wherein said disease is at least one selected from the group consisting of arterial sclerosis and retinal angiogenesis, said method comprising: administering a pharmacologically effective amount of an integrin expression inhibitor of a sulfonamide compound represented by formula (I a ), a pharmacologically acceptable salt thereof or a hydrate thereof, to a patient in need thereof for treating or improving said disease: wherein in formula (I a ): the A a ring represents a monocyclic or bicyclic aromatic ring optionally having a substituent; the B a ring represents an optionally substituted 6-membered cyclic unsaturated hydrocarbon or unsaturated 6-membered heterocycle containing one nitrogen atom as a heteroatom; the C a ring represents an optionally substituted 5-membered heterocycle containing 1 or 2 nitrogen atoms; R la represents a hydrogen atom or a C 1 -C 6 alkyl group; W a represents a single bond or —CH═CH—; Y a represents a carbon atom or nitrogen atom; and Z a represents a nitrogen atom or —N(R 2a )—, wherein R 2a is a hydrogen atom or a lower alkyl group.