Patent ID: 7094758

Claim:
A method of screening for an agent which modulates the interaction of an AV peptoid with an Inhibitor of Apoptosis Protein (IAP), said method comprising the steps of: incubating a mixture comprising: an AV peptoid, wherein the AV peptoid is a peptide comprising AX 1 , wherein X 1 is V, I or L, or a peptide mimetic thereof, which interacts with an IAP as measured by IAP binding, procaspase-3 activation or promotion of apoptosis, a second baculoviral IAP repeat domain (BIR2) of XIAP, a candidate agent; under conditions whereby, but for the presence of said agent, the peptoid specifically interacts with the BIR2 at a reference affinity; detecting a specific interaction of the peptoid with the BIR2 to determine an agent-biased affinity, wherein a difference between the agent-biased affinity and the reference affinity indicates that the agent modulates the interaction of the peptoid to the BIR2 of the XIAP.