Patent ID: 7803832

Claim:
A method of treating a parasitic infestation or infection in a non-human animal or plant comprising administration of a therapeutically effective amount of a compound of Formula 1 or a pharmaceutically, veterinarily, or agriculturally acceptable salt thereof, wherein R 1 is phenyl optionally substituted by one or more groups independently selected from the group consisting of halo, cyano, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 , alkoxy, C 1-6 haloalkoxy, C 1-6 alkanoyl, C 1-6 haloalkanoyl, —S(O) n C 1-6 alkyl, —S(O) n C 1-6 haloalkyl and pentafluorothio; R 2 is cyano; R 3 is C 1-6 alkyl, C 1-6 haloalkyl, or —(C 0-3 alkylene)-phenyl; R 4 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, —(C 0-3 alkylene)-R 7 or —(C 1-3 alkylene)-R 8 ; or R 3 and R 4 taken together with the nitrogen and sulphur atoms to which they are attached form a 4 to 7-membered ring; R 5 is hydrogen; R 6 is C 1-6 alkyl or haloalkyl; R 7 is C 3-8 cycloalkyl, —S(O) n R 9 , phenyl, het, —CO 2 R 6 or C(O)N(R a )R b ; R 8 is hydroxy, C 1-6 alkoxy, C 1-6 haloalkoxy, cyano, —N(R a )R b or —O—C(O)R 6 ; R 9 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, —N(R a )R b , phenyl or het; R a and R b independently represent hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl or C 2-6 haloalkenyl, or R a additionally is —(C 0-3 alkylene)-C 3-8 cycloalkyl, —(C 0-3 alkylene)-phenyl or —(C 0-3 alkylene)-het, or together R a and R b form a 4- to 7-membered ring, optionally substituted by one or more groups independently selected from the group consisting of halo, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy; n is the integer 0, 1 or 2; where het represents a four- to seven-membered heterocyclic group, which is aromatic or non-aromatic and which contains one or more heteroatoms selected from the group consisting of nitrogen, oxygen, sulfur and mixtures thereof; where both phenyl and het may be optionally substituted, where the valence allows, by one or more substituents independently selected from the group consisting of halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkenyl, C 1-6 haloalkenyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 3-8 cycloalkyl, C 1-6 alkanoyl, C 1-6 haloalkanoyl, C 1-6 alkylcarbonyloxy, C 1-6 alkoxycarbonyl and NR a R b ; where C 3-8 cycloalkyl may be optionally substituted by one or more groups independently selected from the group consisting of halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkenyl, C 1-6 haloalkenyl, hydroxy, C 1-6 alkoxy and C 1-6 haloalkoxy; and where any alkylene or alkenylene group may be optionally substituted by one or more halo.