Patent ID: 7060697

Claim:
A compound of Formula I: in which: A is —C(O)OR 5 ; wherein each R 5 is independently chosen from hydrogen and C 1-6 alkyl; X 1 and X 2 are each independently selected from a bond or C 1-6 alkylene; Z is chosen from: wherein the left and right asterisks of Z indicate the point of attachment between—C(R 3 )(R 4 )— and A of Formula I, respectively; R 6 is chosen from hydrogen and C 1-6 alkyl; R 1 is chosen from C 6-10 aryl optionally substituted by a radical chosen from halo, C 6-10 arylC 0-4 alkyl, C 3-8 cycloalkylC 0-4 alkyl and C 1-6 alkyl; wherein any aryl, or cycloalkyl of R 1 can be optionally substituted by one to five radicals chosen from halo, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; and any alkyl group of R 1 can optionally have a methylene replaced by an atom or group chosen from —S—, —S(O)—, —S(O) 2 —, —NR 5 — and —O—; wherein R 5 is chosen from hydrogen or C 1-6 alkyl; R 2 is chosen from C 1-6 alkyl, C 1-6 alkoxy, C 3-12 cycloalkylC 0-4 alkyl, halo, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 3 and R 4 are independently chosen from hydrogen, C 1-6 alkyl, halo, hydroxy, C 1-6 alkoxy, halo-substituted C 1-6 alkyl and halo-substituted C 1-6 alkoxy; and the pharmaceutically acceptable salts, hydrates, solvates, and prodrugs thereof.