Patent ID: 6908626

Claim:
A formulation comprising: (a) at least one population of nanoparticulate of at least one poorly soluble active agent having an effective average particle size of less than about 1 micron; (b) at least one surface stabilizer adsorbed onto the surface of the nanoparticulate active agent particles wherein the concentration of the surface stabilizer is from about 0.5% to about 99.999%(w/w), based upon the total weight of the nanoparticulate active agent and the surface stabilizer, and wherein the surface stabilizer is selected from the group consisting of a nonionic surface stabilizer, an anionic surface stabilizer, a cationic surface stabilizer, and an ionic surface stabilize; and (c) at least one population of microparticulate active agent, which is either the same as or different from the active agent of (a), and having an effective average particle size of greater than about 1 micron and less than about 10 microns wherein the concentration of the microparticulate agent is from about 5% to about 85%, based upon the total weight of the microparticulate active agent, nanoparticulate active agent, and surface stabilizer.