Patent ID: 7834193

Claim:
A method for production of 1 -(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)-propyl]-2,3-dihydro-1H-indole-7-carboxamide of the structural formula (3): comprising mixing 3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]-ethyl}amino)propyl]2,3-dihydro-1H-indol-1-yl}propyl benzoate of the structural formula (1): with oxalic acid to yield 3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]-ethyl)amino)propyl]-2,3-dihydro-1H-indol-1-yl)propyl benzoate monooxalate, subsequently hydrolyzing the oxalate to yield 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile of the structural formula (2): and hydrolyzing the compound of the structural formula (2).