Patent ID: 8742094

Claim:
A method for the solid-phase based production of a compound of the general formula (I): or a salt thereof, wherein R 1 is ONucl or Nucl, wherein Nucl is a nucleoside selected from the group consisting of adenosine, guanosine, cytidine, thymidine, uridine, deoxyadenosine, deoxyguanosine, deoxycytidine, deoxyuridine, and deoxythymidine, or an analog thereof, R 2 is an organic compound or phosphate or pyrophosphate, comprising the steps of: a) adding a succinyl linker (L) HOOC—(CH 2 ) 2 —COOH or —OC—(CH 2 ) 2 —CO— to a compound of the general formula (II) wherein R 1 is as defined above and the compound (II) may be substituted one or more times with X, X being an electron acceptor, and where the succinyl linker (L) is covalently bonded to an OH group of the sugar component of the nucleoside of R 1 or to a component analogous to a sugar component of the nucleoside analog of R 1 , for the production of a compound of the formula (III) wherein X and R 1 are as defined above and L=linker, and immobilizing the compound (III) by covalently binding the linker (L) to a solid phase having at least one amino group —NH 2 , or b) covalently binding a succinyl linker HOOC—(CH 2 ) 2 —COOH or —OC—(CH 2 ) 2 —CO—, which has been covalently bound to a solid phase, to the compound according to the general formula (II), and c) reacting the products from step a) or b) with a nucleophile identical to R 2 or comprising R 2 .