Patent ID: 8501436

Claim:
A method for preparing carbamic acid 1-aryl-2-tetrazolyl ethyl ester, represented by Chemical Formula 1, comprising: subjecting an arylketone, represented by Chemical Formula 2, to (R)-selective asymmetric reduction to form an alcohol compound of (R)-configuration, represented by Chemical Formula 3; and carbamating said alcohol: wherein, R 1 , and R 2 are independently selected from a group consisting of hydrogen, halogen, perfluoroalkyl, an alkyl of 1 to 8 carbon atoms, a thioalkoxy of 1 to 8 carbon atoms, and an alkoxy of 1 to 8 carbon atoms; one of A 1 and A 2 is CH with the other being N; wherein said (R)-selective asymmetric reduction is achieved by biological asymmetric reduction that is carried out in a buffer containing the arylketone of Chemical Formula 2, a microbial strain producing oxidoreductase that is selected from a group consisting of yeasts of Candida genus including Candida parapsilosis and Candida rugosa ; yeasts of Pichia genus including Pichia anomala and Pichia jadinii ; yeasts of Saccharomyces genus including Baker's yeast, Saccharomyces cerevisiae and Saccharomyces pastorianus ; yeasts including Rhodotorula mucilaginosa and Trigonopsis variabilis ; bacteria including Klebsiella pneumoniae, Enterobacter cloacae, Erwinia herbicola, Micrococcus luteus, Bacillus stearothermophilus, Rhodococcus erythropolis and Rhodococcus rhodochrous ; fungi including Mucor racemosus and Geotrichum candidum ; and a combination thereof, and a cosubstrate; or said (R)-selective asymmetric reduction is achieved by chemical asymmetric reduction with a chiral borane reductant, or by asymmetric catalytic hydrogenation, or by asymmetric catalytic transfer hydrogenation.