Patent ID: 8491903

Claim:
A method of treating a neurodementing disease in a patient comprising administering to said patient a therapeutically acceptable amount of an antibody, wherein the antibody comprises: a full set of six CDRs, three from the variable heavy chain region (VH) (SEQ ID NOs: 15, 23 and 29) and three from the variable light chain region (VL) (SEQ ID NOs: 33, 41 and 45); or a full set of six CDRs, three from the variable heavy chain region (VH) (SEQ ID NOs: 13, 21 and 28) and three from the variable light chain region (VL) (SEQ ID NOs: 34, 38 and 44); or a full set of six CDRs, three from the variable heavy chain region (VH) (SEQ ID NOs: 14, 27 and 30) and three from the variable light chain region (VL) (SEQ ID NOs: 33, 42 and 44); or the three CDRs from the VL and the three CDRs from the VH amino acid sequence pairs of SEQ ID NO: 53 and SEQ ID NO: 60, SEQ ID NO: 47 and SEQ ID NO: 56, SEQ ID NO: 48 and SEQ ID NO: 57, SEQ ID NO: 145 and SEQ ID NO: 60, SEQ ID NO: 51 and SEQ ID NO: 60, SEQ ID NO: 52 and SEQ ID NO: 60, SEQ ID NO: 146 and SEQ ID NO: 60, SEQ ID NO: 53 and SEQ ID NO: 148, SEQ ID NO: 55 and SEQ ID NO: 61, SEQ ID NO: 145 and SEQ ID NO: 62, SEQ ID NO: 54 and SEQ ID NO: 60, SEQ ID NO: 54 and SEQ ID NO: 61, SEQ ID NO: 54 and SEQ ID NO: 148, SEQ ID NO: 145 and SEQ ID NO: 148, or SEQ ID NO: 146 and SEQ ID NO: 61; wherein said antibody binds to dimeric forms of Aβ with higher affinity than to monomeric forms of Aβ; and wherein the neurodementing disease is selected from the group consisting of Alzheimer's disease, Down's syndrome, dementia with Lewy bodies, fronto-temporal dementia and cerebral amyloid angiopathy.