Patent ID: 8426178

Claim:
An engineered ketoreductase polypeptide, wherein the polypeptide comprises an amino acid sequence that is at least 90% identical to SEQ ID NO:2, and wherein the polypeptide has the following features at positions corresponding to positions of SEQ ID NO: 2: (a) the residue at position 94 is a glycine, (b) the residue at position 145 is a phenylalanine or leucine; (c) the residue at position 190 is a proline; and (d) the residue at position 153 is a threonine or a valine, the residue at position 195 is a methionine, the residue at position 206 is phenylalanine, tryptophan, or tyrosine, and/or the residue at position 233 is glycine.