Patent ID: 7659281

Claim:
A compound having the structure wherein A is selected from wherein R 1 and R 2 are the same or different and are independently selected from H or lower alkyl; B is wherein n is 1 or 2; R 6 (a substituent in the benzo ring) is, when n=1, nitro, —N(H)C(O)NR 8 R 9 , —N(H)C(O)CH 2 NMe 2 , —N(H)C(O)NH 2 tetrazole linked through its carbon atom and which is optionally substituted by methyl, methyl substituted with N(H)SO 2 Me or N(H)C(O)NHMe, SO 2 N(H)R 10 , C(O)N(H)R 11 , —N═C(NH 2 )NH 2 or or R 6 is identical at each occurrence and is, when n=2, CN, CO 2 H, COOMe; or R 6 is, when R 3 is 3-carboxy-4-fluorophenyl and n=1 or 2, H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclo, or an alkyl substituent; wherein each of the above R 6 groups may be independently substituted with a member selected from the group consisting of halogen, nitro, cyano, OR 22 , alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclo; wherein R 22 is selected from the group consisting of H, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl or C 3 -C 9 heterocyclo; R 3 and R 4 are the same or different and are independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heterocyclo (wherein the attachment atom in the heterocyclo group is a carbon); wherein each of the above R 3 and R 4 groups may be independently substituted with a member selected from the group consisting of halogen, nitro, cyano, OR 22 , alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclo; wherein R 22 is selected from the group consisting of H, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 8 -C 10 aryl or C 3 -C 9 heterocyclo; R 8 is H, or methyl; R 9 is a) alkyl which is optionally substituted by one or more groups independently selected from carboxy, methylamino, dimethylamino, aminoalkyl, and/or hydroxyl, b) alkyl substituted by carboxy and amino, or c) heterocyclo; wherein each of the above R 9 groups may be independently substituted with a member selected from the group consisting of halogen, nitro, cyano, OR 22 , alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclo; wherein R 22 is selected from the group consisting of H, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 8 -C 10 aryl or C 3 -C 9 heterocyclo; R 10 is H, or alkyl which is optionally substituted with one or more groups independently selected from hydroxy, dimethylamino and/or 4-morpholino, SO 2 Me, C(O)Me, or C(O)NHMe; R 11 is alkyl (which is optionally substituted with dimethylamino), MeO, SO 2 Me, or heterocyclo; or a pharmaceutically acceptable salt thereof, or an ester thereof, a prodrug ester thereof, and all stereoisomers thereof.