Patent ID: 7465799

Claim:
A compound having the Formula II: or a pharmaceutically acceptable salt thereof, wherein: Y is O, (CR 3 R 4 ) p or NR 5 ; p is 1 to 3; X is OH, OR 3 , OC 1-6 alkyl, OC(═O)aryl, OC(═O)C 1-6 alkyl, OC(═O)OC 1-6 alkyl or NR 3 R 3′ ; each R 1 , R 2 R 3 , R 3′ and R 4 is independently hydrogen, C 1-6 alkyl, C 1-6 perhaloalkyl, OC 1-6 perhaloalkyl, halogen, thioalkyl, CN, OH, SH, (CH 2 ) n OSO 3 H, (CH 2 ) n SO 3 H, (CH 2 ) n CO 2 R 6 , OSO 3 R 6 , SO 2 R 6 , SO 3 R 6 , PO 3 R 6 R 7 , (CH 2 ) n SO 2 NR 8 R 9 , (CH 2 ) n C(═O)NR 8 R 9 , C(═O)R 12 , aryl, heterocyclo, C(═O)aryl, C(═O)heterocyclo, OC(═O)aryl, OC(═O)heterocyclo, Oaryl, Oheterocyclo, arylalkyl, C(═O)arylalkyl, OC(═O)arylalkyl, Oarylalkyl, alkenyl, alkynyl, or NHCOR 8 , wherein any of said alkyl, Oalkyl, aryl, heterocyclo, C(═O)aryl, C(═O)heterocyclo, O—C(═O)aryl, O—C(═O )heterocyclo, O-aryl, O-heterocyclo, arylalkyl, C(═O)arylalkyl, O—C(═O)arylalkyl, O-arylalkyl, alkenyl or alkynyl can optionally be substituted with up to three substituents selected from halogen, C 1-6 alkyl, OC 1-6 alkyl and CN; each R 6 and R 7 is independently selected from the group consisting of hydrogen and C 1-6 alkyl that is optionally substituted with up to three substituents selected from OH, CF 3 , SH and halogen; each R 5 , R 8 and R 9 is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, thioalkyl, OH, (CH 2 ) 1 OSO 3 H, (CH 2 ) 1 SO 3 R 10 , (CH 2 ) n CO 2 R 10 , SO 3 R 10 , PO 3 R 10 R 11 , (CH 2 ) n SO 2 (CH 2 ) n NR 10 R 11 , (CH 2 ) n CONR 10 R 11 , COR 10, aryl, heterocyclo, C(═O)aryl, C(═O)heterocyclo, O—C(═O)aryl, O—C(═O)heterocyclo, Oaryl, Oheterocyclo, arylalkyl, C(═O)arylalkyl, OC(═O)arylalkyl, Oarylalkyl, alkenyl, or alkynyl, wherein any of said alkyl, aryl, heterocyclo, C(═O)aryl, C(═O)heterocyclo, OC(═O)aryl, OC(═O)heterocyclo, Oaryl, Oheterocyclo, arylalkyl, C(═O)arylalkyl, OC(═O)arylalkyl, Oarylalkyl, alkenyl or alkynyl can optionally be substituted with up to three substituents selected from halogen, C 1-6 alkyl, OC 1-6 alkyl and CN; each n is an independently selected integer from 0 to 6; each l is an independently selected integer from 1 to 6; each R 10 and R 11 is independently selected from the group consisting of hydrogen and C 1-6 alkyl that is optionally substituted with up to three substituents selected from OH, CF 3 , SH and halogen; each R 12 is independently hydrogen, C 1-6 alkyl, C 1-6 perhaloalkyl, OC 1-6 alkyl, OC 1-6 perhaloalkyl, thioalkyl, OH, (CH 2 ) 1 OSO 3 H, (CH 2 ) 1 SO 3 H, (CH 2 ) 1 CO 2 R 6 , (CH 2 ) 1 SO 2 NR 8 R 9 ,(CH 2 ) n C(═O)NR 8 R 9 , NR 8 R 9, alkenyl, alkynyl, or NHCOR 8 , wherein any of said alkyl, Oalkyl, alkenyl or alkynyl can optionally be substituted with up to three substituents selected from halogen, C 1-6 alkyl, OC 1-6 alkyl and CN; and Z is aryl, arylalkyl, heteroaryl or heterocyclo, wherein each of said aryl, arylalkyl, heteroaryl and heterocyclo is optionally substituted.