Patent ID: 8329209

Claim:
A method of preparing a composition for oral delivery of a pharmaceutically active ingredient comprising: a) preparing an acidic aqueous solution comprising at least one bioadhesive polymer, wherein the acidic aqueous solution has a pH low enough to gelatinize the bioadhesive polymer; b) combining an oligosaccharide into the solution with the gelatinized bioadhesive polymer to form an oligosaccharide-bioadhesive polymer solution; c) combining an emulsifier with a sugar, wherein the sugar and emulsifier form a mediating compound; d) introducing the mediating compound into the oligosaccharide-bioadhesive polymer solution to form a smooth emulsion while maintaining the acidic pH of the solution; e) adding a pharmaceutically active agent into the smooth emulsion; and f) precipitating the emulsion into a phosphate containing cross-linking solution.