Patent ID: 6927232

Claim:
A method of treating Alzheimer's disease comprising administering to a person in need of such treatment a therapeutically effective amount of a compound of the formula wherein R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of —(CH 2 ) n -halogen, lower alkoxy, —(CH 2 ) n —NRR′, —(CH 2 ) n —N(R)—C(O)-lower alkyl, aryl, unsubstituted heteroaryl or heteroaryl substituted by one or more lower alkyl; R, R′ and R″ are independently selected from the group consisting of hydrogen or lower alkyl; A is selected from the group consisting of —CH═CH— and —C≡C—; and B is selected from the group consisting of wherein R 6 is selected from the group consisting of lower alkyl, —(CH 2 ) n —C(O)OR and halogen; R 7 is selected from the group consisting of lower alkyl, —(CH 2 ) n —C(O)OR′, halogen, nitro, unsubstituted heteroaryl and heteroaryl substituted by lower alkyl or cycloalkyl; R 8 is selected from the group consisting of lower alkyl, —(CH 2 ) n —OH, —(CH 2 ) n —C(O)OR″ and aryl; R 9 is lower alkyl; R 10 is selected from the group consisting of lower alkyl and halogen; R 11 is alkyl; R 21 is lower alkyl; R 22 is from the group consisting of lower alkyl and lower alkyl carrying at least one substituent selected from hydroxy and halogen; R 23 is selected from the group consisting of lower alkyl, lower alkanoyl and nitro; R 24 , R 25 and R 26 are each independently lower alkyl; and n is 0, 1, 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt thereof.