Patent ID: 8041515

Claim:
A method of categorizing a cell response to a biologically active agent into mechanism-specific response profile group, comprising: a. providing a device for measuring cell-substrate impedance, wherein said device comprises at least two wells, further wherein said device is operably connected to an impedance analyzer; b. adding cells to said at least two wells; c. monitoring impedance of said at least two wells at time intervals over a time period and optionally determining cell indices from impedance values; d. introducing at least one biologically active agent to at least one and a control to another of said at least two cells, wherein said introduction occurs during said time period such that at least one of said impedance values is obtained prior to said introduction; e. generating an impedance-based curve or optionally a cell index curve for each of said at least one biologically active agent and said control; f. comparing said impedance-based curves or optionally said cell index curves between said at least one biologically active agent wells and said control well; and if significantly different g. categorizing said impedance-based curve or optionally said cell index curve of said at least one biologically active agent to a group, wherein said group defines a mechanism-specific cellular response profile corresponding to said at least one biologically active agent.