Patent ID: 7186738

Claim:
A compound of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein —N-HET is Q is R 2 and R 3 are independently selected from H, F, Cl, CF 3 , OMe, SMe, Me and Et; T is selected from: wherein: R 6h is hydrogen or (1–4C)alkyl; R 4h and R 5h are independently selected from hydrogen, cyano, hydroxy(1–4C)alkyl, cyano(1–4C)alkyl, phosphoryl(1–4C)alkyl, benzyl (optionally substituted on the phenyl ring by one substituent selected from halo, methyl and methoxy), (1–4C)alkyl, (1–4C)alkyl substituted with ORc (wherein Rc is R 13 CO and R 13 is selected from Rc2b), (1–4C)alkanoyl and (1–4C)alkoxycarbonyl; (Rc2b) (1–10C)alkyl {optionally substituted by one or more groups (including germinal disubstitution) each independently selected from hydroxy, (1–10C)alkoxy, (1–4C)alkoxy-(1–4C)alkoxy, (1–4C)alkoxy-(1–4C)alkoxy-(1–4C)alkoxy, (1–4C)alkanoyl, carboxy, phosphoryl [—O—P(O)(OH) 2 , and mono- and di-(1 –4C)alkoxy derivatives thereof], phosphiryl [—O—P(O)(OH) 2 and mono- and di-(1 –4C)alkoxy derivatives thereof], and amino; and/or optionally substituted by one group selected from phosphonate [phosphono, —P(O)(OH) 2, and mono- and di-(1–40C)alkoxy derivatives thereof], phosphinate [—P(OH) 2 end mono- and di-(1–4C)alkoxy derivatives thereof], cyano, halo, trifluoromethyl, (1–4C)alkoxycarbonyl, (1–4C)alkoxy-(1–4C)alkoxycarbonyl, (1–4C)alkoxy-(1–4C)alkoxy-(1–4C)alkoxycarbonyl, (1–4C)alkylamino, di((1–4C)alkyl)amino, (1–6C)alkanoylamino, (1–4C)alkoxycarbonylamino, N-(1–4C)alkyl-N-(1–6C)alkanoylamino, (1–4C)alkylaminocarbonyl, di((1–4C)alkyl)aminocarbonyl, (1–4C)alkylS(O) p NH—(1–4C)alkylS(O) p -((1–40)alkyl)N—, fluoro(1–4C)alkylS(O) p NH—, fluoro(1–4C)alkylS(O) p ((1–4C)alkyl)N—, (1–4C)alkylS(O) q — [the (1–4)alkyl group of (1–4C)alkylS(O) q — being optionally substituted by one substituent selected from hydroxy, (1–4C)alkoxy, (1–4C)alkanoyl, phosphoryl [—O—P(O)(OH) 2, and mono- and di-(1–4C)alkoxy derivatives thereof], phosphiryl [—O—P(OH) 2 and mono- and di-(1–4C)alkoxy derivatives thereof], amino, cyano, halo, trifluoromethyl, (1–4C)alkoxycarbonyl, (1–4C)alkoxy-(1 –4C)alkoxycarbonyl, (1–4C)alkoxy-(1–4C)alkoxy-(1–4C) alkoxycarbonyl, carboxy, (1–4C)alkylamino, di((1–4C)alkyl)amino, (1–6C)alkanoylamino, (1–4C)alkoxycarbonylamino, N-(1–4C)alkyl-N-(1–6C)alkanoylamino, (1–4C)alkylaminocarbomyl, di((1–4C)alkyl)aminocarbonyl, (1–4C)alkylS(O) p NH—, (1–4C)alkylS(O) p —((1–4C)alkyl)N—, and (1–4C)alkylS(O) q —.