Patent ID: 7211419

Claim:
A large subunit of carbamoylphosphate synthetase which has an amino acid sequence encoded by a DNA defined in the following (A) or (B): (A) a DNA having the nucleotide sequence of SEQ ID NO: 19; or (B) a DNA which hybridizes with a DNA having the nucleotide sequence defined in SEQ ID NO: 19 under stringent conditions which entail a temperature of 60° C., a salt concentration of 0.1×SSC, and 0.1% SDS, and which encodes a protein having carbamoylphosphate synthetase activity, wherein the amino acid sequence corresponding to the positions from 947 to 951 of SEQ ID NO:20 is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 9, and feedback inhibition by uridine 5′-monophosphate is desensitized.