Patent ID: 7294636

Claim:
A compound of formula (I): wherein: A is absent or is CH 2 CH 2 ; R 1 is halo, hydroxy, nitro, (CH 2 ) n S(O) k (C 1-6 alkyl), (CH 2 ) n S(O) 2 NH 2 , (CH 2 ) n S(O) 2 NH(C 1-6 alkyl), (CH 2 ) n S(O) 2 NHCHO, (CH 2 ) n S(O) 2 N(C 1-6 alkyl) 2 , OS(O) 2 (C 1-6 alkyl), cyano, C 1-6 alkyl, C 1-6 alkoxy, NH 2 , NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , C(O)NH 2 , C(O)NH(C 1-6 alkyl), C(O)N(C 1-6 alkyl) 2 , C(O)[N-linked heterocyclyl], CO 2 H, CO 2 (C 1-6 alkyl), NHC(O)(C 1-6 alkyl), NHC(O)O(C 1-6 alkyl), (CH 2 ) n NHS(O) 2 (C 1-6 alkyl), C(O)(C 1-6 alkyl), CF 3 , OCF 3 , phenyl, heteroaryl, (C 1-4 alkyl)phenyl, (C 1-4 alkyl)heteroaryl, NHC(O)phenyl, NHC(O)heteroaryl, NHC(O)(C 1-4 alkyl)phenyl, NHC(O)(C 1-4 alkyl)heteroaryl, NHS(O) 2 phenyl, NHS(O) 2 heteroaryl, NHS(O) 2 (C 1-4 alkyl)phenyl, NHS(O) 2 (C 1-4 alkyl)heteroaryl, NHC(O)NH(C 1-6 alkyl), NHC(O)NH(C 3-7 cycloalkyl), NHC(O)NHphenyl, NHC(O)NHheteroaryl, NHC(O)NH(C 1-4 alkyl)phenyl or NHC(O)NH(C 1-4 alkyl)heteroaryl; wherein the foregoing phenyl and heteroaryl groups are optionally substituted by halo, hydroxy, nitro, S(O) m (C 1-4 alkyl), S(O) 2 NH 2 , S(O) 2 NH(C 1-4 alkyl), S(O) 2 N(C 1-4 alkyl) 2 , cyano, C 1-4 alkyl, C 1-4 alkoxy, C(O)NH 2 , C(O)NH(C 1-4 alkyl), C(O)N(C 1-4 alkyl) 2 , CO 2 H, CO 2 (C 1-4 alkyl), NHC(O)(C 1-4 alkyl), NHS(O) 2 (C 1-4 alkyl), C(O)(C 1-4 alkyl), CF 3 or OCF 3 ; R 2 is phenyl, halophenyl, thienyl or halothienyl; R 3 is hydrogen or methyl; R 4 is a five membered heterocycle containing at least one carbon atom, one to four nitrogen atoms and, optionally, one oxygen or sulphur atom, said heterocycle being optionally substituted by oxo, C 1-6 alkyl, H 2 NC(O), (phenylC 1-2 alkyl)HNC(O), C 1-2 alkyl(phenyl) [which is optionally substituted by halogen, C 1-4 alkyl, C 1-4 alkoxy, CF 3 , OCF 3 , S(C 1-4 alkyl), S(O)(C 1-4 alkyl) or S(O) 2 (C 1-4 alkyl)], S(C 1-4 alkyl), S(C 1-2 alkyl(phenyl)), NH 2 or phenyl; the five membered heterocycle being optionally fused to a cyclohexane, piperidine, benzene, pyridine, pyridazine, pyrimidine or pyrazine ring; the ring carbon atoms of said fused cyclohexane, piperidine, benzene, pyridine, pyridazine, pyrimidine or pyrazine ring being optionally substituted by halogen, cyano, C 1-4 alkyl, C 1-4 alkoxy, CF 3 , OCF 3 , NH 2 , S(C 1-4 alkyl), S(O)(C 1-4 alkyl) or S(O) 2 (C 1-4 alkyl); and the nitrogen of the fused piperidine ring being optionally substituted by C 1-4 alkyl {which is optionally substituted by oxo, halogen, OH, C 1-4 alkoxy, OCF 3 , C(O)O(C 1-4 alkyl), CN, C(O)NH 2 , C(O)NH(C 1-4 alkyl), C(O)N(C 1-4 alkyl) 2 , NH 2 , NH(C 1-4 alkyl) or N(C 1-4 alkyl) 2 }, C(O)(C 1-4 alkyl) {wherein the alkyl is optionally substituted by C 1-4 alkoxy or fluoro}, C(O)O(C 1-4 alkyl), C(O)NH 2 , C(O)NH(C 1-4 alkyl), C(O)N(C 1-4 alkyl) 2 or S(O) 2 (C 1-4 alkyl) {wherein the alkyl is optionally substituted by fluoro}; k, m and n are, independently, 0, 1 or 2; or a pharmaceutically acceptable salt thereof.