Patent ID: 8460662

Claim:
A method of alleviating or reducing pancreatic cancer in a human subject comprising administering to said subject an anti-human IGF1-R antibody, or an antigen binding fragment thereof, wherein said anti-human IGF1-R antibody or fragment comprises a light chain variable region and a heavy chain variable region, and wherein: a. said light chain variable region comprises the amino acid sequence of SEQ ID NO:32; and said heavy chain variable region comprises the amino acid sequence of SEQ ID NO:136; or b. said light chain variable region comprises: i. the CDR 1 sequence of residues 24 through 39 of SEQ ID NO:32; and ii. the CDR 2 sequence of residues 55 through 61 of SEQ ID NO:32; and iii. the CDR 3 sequence of residues 94 through 102 of SEQ ID NO:32; and said heavy chain variable region comprises: i. the CDR 1 sequence of residues 31 through 36 of SEQ ID NO:136; and ii. the CDR 2 sequence of residues 51 through 66 of SEQ ID NO:136; and iii. the CDR 3 sequence of residues 99 through 108 of SEQ ID NO:136.