Patent ID: 7109195

Claim:
A method for treating a cancer comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to a hexacyclic compound of formula (1B), wherein the cancer is colorectal cancer, lung cancer, breast cancer, stomach cancer, cervical cancer or bladder cancer wherein R 1 is hydrogen; (C1–C10) alkyl, optionally substituted with one to three moieties independently selected from the group consisting of (C1–C5) alkoxy, hydroxyl, halogen, amino, mono-(C1–C5) alkylamino, di-(C1–C5) alkylamino and (C3–C7) cycloalkyl, a heterocyclic ring and aryl in which the aryl ring is optionally substituted with one to three moieties independently selected from the group consisting of hydroxy, alkoxy, halogen, amino, mono-(C1–C5) alkylamino and di-(C1–C5) alkylamino; R 2 is hydrogen; amino; (C1–C5) alkyl, (C1–C5) alkoxy, (C1–C5) alkylthio, mono-(C1–C5) alkylamino, di-(C1–C5) alkylamino optionally substituted with one to three moieties independently selected from the group consisting of (C1–C5) alkoxy, hydroxy, halogen, amino, (C3–C7) cycloalkyl, heterocyclic ring or aryl in which the aryl ring is optionally substituted with one to three moieties independently selected from the group consisting of hydroxy, (C1–C5) alkoxy, amino, mono-(C1–C5) alkylamino or di-(C1–C5) alkylamino; R 3 and R 4 are independently hydrogen, halogen or (C1–C5) alkyl; or pharmaceutically acceptable salts thereof.