Patent ID: 8354440

Claim:
A method of inhibiting translation initiation in a cell comprising contacting the cell with a compound of formula II, formula IX, X, XI, XII, XIII or XIV wherein the compound of formula II is: wherein R 1 is selected from the group consisting of H, 5-bromo, 5-chloro, 7-bromo, 5-iodo, 5-OCF 3 , 5-sulfonic acid, 5-nitro, 4-bromo, 6-bromo, 5-ethyl, 7-ethyl, 4-ethyl, 6-ethyl, 7-iodo, 5-fluoro, 7-COOH, 7-COOMe and 4-Cl; and R 2 is selected from the group consisting of 7-formamide-N-[2-(4-amino-phenyl)-ethyl], 7-CO 2 H, 7-CH 2 OH, 7-CH 2 —N-imidazole and H with the proviso that R 1 and R 2 cannot both be H, and with the further proviso that when R 2 is H, R 1 cannot be 5-chloro, 5-nitro or 5-fluoro; the compound of formula IX is: wherein R is selected from the group consisting of —CH 2 -(4-Cl)Ph, —CH 2 CHCH 2 , —CH 2 OH, —CH 2 CO 2 H, —CH 2 OCH 2 CHCH 2 , —SO 2 (4-O-n-Bu)Ph, —SO 2 (4-O-Ph)Ph, —SO 2 (4-NHAc)Ph, —SO 2 (4-CH 2 CH 2 CO 2 Me)Ph, —SO 2 (4-OMe)Ph and —SO 2 (4-t-Bu)Ph; the compound of formula X is: the compound of formula XI is: the compound of formula XII: the compound of formula XIII: wherein R is selected from the group consisting of 2-Thiophene, —(CH 2 ) 11 CH 3 , —CH 2 Ph, —CCH, -cyclohexyl and —C 6 F 5 ; and the compound of formula XIV is: wherein R is selected from the group consisting of H, 3-Cl, 3-F, 3-Me and 3-t-Bu.