Patent ID: 7713932

Claim:
A substantially monodispersed calcitonin oligomer conjugate mixture consisting of a salmon calcitonin coupled to two oligomer subunits, wherein each oligomer comprises a polyalkylene glycol moiety, wherein the conjugate consists of a first oligomer subunit and a second oligomer subunit wherein the first oligomer subunit is covalently coupled to Lys 11 of the calcitonin drug and the second oligomer subunit is covalently coupled to Lys 18 of the calcitonin drug, wherein the substantially monodispersed calcitonin drug-oligomer conjugate consisting of the structure of Formula I: wherein x is an integer from 5 to 9; y is an integer from 4 to 10; and z is 2 which is the number of conjugation sites on the calcitonin.