Patent ID: 7964567

Claim:
A method for treating cancer comprising administering to a patient in need thereof an effective amount of an antibody-drug conjugate compound having the formula IIa: or a pharmaceutically acceptable salt thereof, wherein: Ab is an antibody that specifically binds to an antigen expressed by the cancer, R 17 is selected from the group consisting of C 1 -C 10 alkylene-, —C 3 -C 8 carbocyclo-, —O—(C 1 -C 8 alkyl)-, -arylene-, —C 1 -C 10 alkylene-arylene-, -arylene-C 1 -C 10 alkylene-, —C 1 -C 10 alkylene-(C 3 -C 8 carbocyclo)-, —(C 3 -C 8 carbocyclo)-C 1 -C 10 alkylene-, —C 3 -C 8 heterocyclo-, —C 1 -C 10 alkylene-(C 3 -C 8 heterocyclo)-, —(C 3 -C 8 heterocyclo)-C 1 -C 10 alkylene-, -—(CH 2 CH 2 O) r and —(CH 2 CH 2 O) r —CH 2 —; r is an integer rangin from 1 to 10; p ranges from 1 to about 20, and D is a drug moiety of Formula D F : the wavy line of D f indicates the covalent attachment site to C(O) in formula IIIa; wherein, independently at each location: R 2 is selected from the group consisting of H and C 1 -C 8 alkyl; R 3 is selected from the group consisting of H, C 1 -C 8 alkyl, C 3 -C 8 carbocycle, aryl, C 1 -C 8 alkyl-aryl, C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), C 3 -C 8 heterocycle and C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); R 4 is selected from the group consisting of H, C 1 -C 8 alkyl, C 3 -C 8 carbocycle, aryl, C 1 -C 8 alkyl-aryl, C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), C 3 -C 8 heterocycle and C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); R 5 is selected from the group consisting of H and methyl; or R 4 and R 5 jointly form a carbocyclic ring and have the formula —(CR a R b ) n — wherein R a and R b are independently selected from the group consisting of H, C 1 -C 8 alkyl and C 3 -C 8 carbocycle and n is selected from the group consisting of 2, 3, 4, 5 and 6; R 6 is selected from the group consisting of H and C 1 -C 8 alkyl; R 7 is selected from the group consisting of H, C 1 -C 8 alkyl, C 3 -C 8 carbocycle, aryl, C 1 -C 8 alkyl-aryl, C 1 -C 8 alkyl-(C 3 -C 8 carbocycle), C 3 -C 8 heterocycle and C 1 -C 8 alkyl-(C 3 -C 8 heterocycle); each R 8 is independently selected from the group consisting of H, OH, C 1 -C 8 alkyl, C 3 -C 8 carbocycle and O—(C 1 -C 8 alkyl); R 9 is selected from the group consisting of H and C 1 -C 8 alkyl; R 10 is selected from aryl or C 3 -C 8 heterocycle; Z is O, S, NH, or NR 12 , wherein R 12 is C 1 -C 8 alkyl; R 11 is selected from H, C 1 -C 20 alkyl, aryl, C 3 -C 8 heterocycle, —(R 13 O) m —R 14 , or —(R 13 O) m —CH(R 15 ) 2 ; m is an integer ranging from 1-1000; R 13 is C 2 -C 8 alkyl; R 14 is H or C 1 -C 8 alkyl; each occurrence of R 15 is independently H, COOH, —(CH 2 ) n —N(R 16 ) 2 , —(CH 2 ) n —SO 3 H, or —(CH 2 ) n —SO 3 —C 1 -C 8 alkyl; each occurrence of R 16 is independently H, C 1 -C 8 alkyl, or —(CH 2 ) n —COOH; and n is an integer ranging from 0 to 6.