Patent ID: 7985746

Claim:
A method of treating an autoimmune disease in a subject in need thereof, comprising administering to said subject a compound in a treatment effective amount; wherein said autoimmune disease is selected from the group consisting of systemic lupus erythematosus, type 1 diabetes mellitus, psoriasis, and atherosclerosis; wherein said compound is a compound of formula I: wherein: Q is —C(R 1 )(R 2 )— or CH═CH— (cis or trans); R 1 and R 2 are independently selected from H, C 1-3 alkyl, C 2-4 alkenyl, or taken together are C 1-6 alkylidene or C 2-6 alkenylenidene; each of R 3 , R 4 , R 6 , and R 7 is independently selected from hydrogen and methyl; X is methylene, ethylene, or propenylene; R 5 is phenyl, quinolinyl, isoquinolinyl, indolyl, furyl, thienyl, pyrazolyl, quinoxalinyl, naphthyl, or pyrrolyl, and substituted with between 0 and 5 substituents independently selected from C 1-3 alkyl, C 1-3 alkoxy, hydroxyl, C 1-3 alkylthio, cyclopropyl, cyclopropylmethyl, and halo; R 8 is H, methyl, ethyl, propenyl, (C 1-3 alkoxy)C 1-3 alkyl, (C 1-3 alkylthio)C 1-3 alkyl, C 1-3 hydroxyalkyl, phenyl, benzyl, furyl, pyrrolyl, imidazolyl, pyrazolyl, isothiazolyl, isooxazolyl, pyridyl, and thienyl; wherein R 8 is substituted with between 0 and 3 substituents independently selected from methyl, ethyl, halo, C 1-3 alkoxy, C 1-3 alkylthio, (C 1-3 alkoxy)C 1-3 alkyl, (C 1-3 alkylthio)C 1-3 alkyl, C 1-3 hydroxyalkyl, (C 1-3 mercaptoalkyl)phenyl, benzyl, furyl, imidazolyl, pyrazolyl, pyrrolyl, isothiazolyl, isooxazolyl, pyridyl, thienyl, pyranyl, dihydropyranyl, tetrahydropyranyl, and cyclopropyl; and each of R a , R b , and R c is independently selected from hydrogen, hydroxyl, methoxy, benzyloxy, fluoro, chloro, amino, methylamino, dimethylamino, and phenoxy; or one pair selected from R a and R b , and R b and R c , taken together, is —O— (CH 2 )—O— or —O—CH 2 —CH 2 —O—; or a pharmaceutically acceptable salt, a C 1-6 alkyl ester or amide, or a C 2-6 alkenyl ester or amide thereof.