Patent ID: 7893048

Claim:
A compound of formula (I): wherein: X is —CH 2 —, —CH 2 CH 2 —, or —CH 2 CH 2 CH 2 —; Y is —CH 2 — or O; Y 1 is —CH 2 — or O; wherein at least one of Y and Y 1 is —CH 2 —; R 1 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl or aryl; wherein said C 1-6 alkyl may be optionally substituted by one or more hydroxy, amino, guanidino, carbamoyl, carboxy, C 1-6 alkoxy, N—(C 1-6 alkyl)amino, N,N—(C 1-6 alkyl) 2 amino, C 1 -C 6 alkylcarbonylamino, C 1-6 alkylS(O) a wherein a is 0-2, C 3-6 cycloalkyl or aryl; and wherein any aryl group may be optionally substituted by one or two substituents selected from halo, hydroxy, C 1-6 alkyl and C 1-6 alkoxy; R 2 and R 3 are independently hydrogen, a branched or unbranched C 1-6 alkyl, C 3-6 cycloalkyl or aryl; wherein said C 1-6 alkyl may be optionally substituted by one or more hydroxy, amino, guanidino, cyano, carbamoyl, carboxy, C 1-6 alkoxy, aryl C 1-6 alkoxy, (C 1 -C 4 alkyl) 3 Si, N—(C 1-6 alkyl)amino, N,N—(C 1-6 alkyl) 2 amino, C 1-6 alkylS(O) a , C 3-6 cycloalkyl, aryl or aryl C 1-6 alkylS(O) a , wherein a is 0-2; and wherein any aryl group may be optionally substituted by one or two substituents selected from halo, hydroxy, cyano, C 1-6 alkyl and C 1-6 alkoxy; R 4 is hydrogen, C 1-6 alkyl, or arylC 1-6 alkyl; wherein R 3 and R 2 may form a ring with 3-7 carbon atoms and wherein R 4 and R 2 may form a ring with 2-6 carbon atoms; and R 5 is selected from halo, nitro, cyano, hydroxy, carboxy, carbamoyl, sulphamoyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkanoyl, C 1-6 alkanoyloxy, N—(C 1-6 alkyl)amino, N,N—(C 1-6 alkyl) 2 amino, C 1-6 alkanoylamino, N—(C 1-6 alkyl)carbamoyl, N,N—(C 1-6 alkyl) 2 carbamoyl, C 1-6 alkylS(O) a wherein a is 0 to 2, C 1-6 alkoxycarbonyl, N—(C 1-6 alkyl)sulphamoyl and N,N—(C 1-6 alkyl) 2 sulphamoyl; or a pharmaceutically acceptable salt, or a prodrug thereof.