Patent ID: 7579186

Claim:
A human monoclonal antibody or monoclonal antibody fragment that binds to a human TGF-β type II receptor, wherein a heavy chain variable region of the human monoclonal antibody or monoclonal antibody fragment is encoded by a V region DNA derived from a V gene segment selected from 3-07 (DP-54), 5-51 (DP-73) and 3-21 (DP-77) and wherein the human monoclonal antibody or monoclonal antibody fragment has one or more activities selected from: (a) suppression of human TGF-β1 stimulus-induced cell growth of human osteosarcoma cell line MG-63; (b) suppression of human TGF-β1 stimulus-induced suppression of cell growth of human lung cancer cell line A549; and (c) suppression of human TGF-β1 stimulus-induced production of a fibronectin or connective tissue growth factor by human osteosarcoma cell line MG-63.