Patent ID: 8637685

Claim:
A compound of formula (I): wherein: R 1 and R 2 are each independently H, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl or (C 3 -C 8 )cycloalkyl; or one of R 1 and R 2 is carboxy and the other is H, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl or (C 3 -C 8 )cycloalkyl; R 3 is H, (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, (C 1 -C 15 )alkoxy, (C 1 -C 15 )alkylthio, (C 1 -C 15 )alkanoyl, (C 1 -C 15 )alkoxycarbonyl, (C 2 -C 15 )alkanoyloxy, hydroxy, mercapto, halo, cyano, or NR a R b ; R 4 is H, hydroxy, (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, (C 1 -C 15 )alkoxy, (C 1 -C 15 )alkylthio, (C 1 -C 15 )alkanoyl, (C 1 -C 15 )alkoxycarbonyl, (C 2 -C 15 )alkanoyloxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, or NR c R d ; R 5 is aryl or heteroaryl, which aryl or heteroaryl is substituted with one or more groups R x , and which aryl or heteroaryl is also optionally substituted with one or more halo, hydroxy, cyano, trifluoromethyl, trifluoromethoxy, NR e R f , (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, (C 1 -C 15 )alkoxy, (C 1 -C 15 )alkanoyl, (C 1 -C 15 )alkoxycarbonyl, —P(═O)(OH) 2 or (C 2 -C 15 )alkanoyloxy; R a and R b are each independently H, (C 1 -C 6 )alkyl, or (C 1 -C 15 )alkanoyl; R c and R d are each independently H, (C 1 -C 6 )alkyl, or (C 1 -C 15 )alkanoyl; R e and R f are each independently H, (C 1 -C 6 )alkyl, or (C 1 -C 15 )alkanoyl; each R x is independently R y or —CH═CH—R y ; each R y is independently aryl or heteroaryl, which aryl or heteroaryl is optionally substituted with one or more groups independently selected from hydroxy, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkoxycarbonyl, (C 2 -C 6 )alkanoyloxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, and NR v R w ; wherein each R v and R w is independently H, (C 1 -C 6 )alkyl, or (C 1 -C 15 )alkanoyl; and the bond represented by is a single or a double bond; wherein any (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, (C 1 -C 15 )alkoxy, (C 1 -C 15 )alkylthio, (C 1 -C 15 )alkanoyl, (C 1 -C 15 )alkoxycarbonyl, or (C 2 -C 15 )alkanoyloxy, of R 1 -R 4 is optionally substituted with one or more halo, hydroxy, cyano, or oxo (═O); or a pharmaceutically acceptable salt thereof.