Patent ID: 8076074

Claim:
A method of detecting the presence or absence of chromosomal abnormalities and a balanced translocation in a test sample of genomic nucleic acid, comprising: (ii) hybridizing to a genomic nucleic acid array: a) said test sample of genomic nucleic acid; b) a reference genomic nucleic acid; (ii) hybridizing at least one probe for detecting a balanced translocation to said test and reference genomic nucleic acid hybridized to said array, wherein at least one of said probes has a sequence that spans a translocation break point; and (iii) determining the relative amount of hybridized test and reference nucleic acids hybridized to the array as well as determining hybridization of said at least one probe for detecting a balanced translocation to said test and reference genomic nucleic acid hybridized to said array, wherein detecting differential binding to said array of said test sample compared to said reference genomic nucleic acid indicates the presence of a chromosomal abnormality, and wherein detecting differential binding of at least one probe for detecting a balanced translocation to said test sample compared to said reference genomic nucleic acid indicates the presence of a balanced translocation.