Patent ID: 8389567

Claim:
A method of treating rheumatoid arthritis in a mammal that would benefit from inhibition of store operated calcium channel activity comprising administering to the mammal a compound having the structure of Formula (VI): wherein: Z is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 heteroalkyl; wherein C 1 -C 6 alkyl and C 1 -C 6 heteroalkyl are independently optionally substituted with at least one substituent selected from F, Cl, Br, I, —CN, —NO 2 , —OH, —CF 3 , —OCF 3 , —OR 8 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 8 heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —NHS(═O) 2 R 8 , —S(═O) 2 N(R 9 ) 2 , —N(R 9 )S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 8 , —N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —N(R 9 )C(═O)N(R 9 ) 2 , —N(R 9 )C(═O)OR 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —OC(═O)N(R 9 ) 2 , —CON(R) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 2 R 8 ; R is CO 2 R 1 , an optionally substituted heteroaryl, or an optionally substituted heterocycloalkyl; R 1 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or benzyl; R 2 and R 4 are independently an aryl, or a heteroaryl, wherein R 2 and R 4 are independently optionally substituted with at least one substituent selected from F, Cl, Br, I, —CN, —NO 2 , —OH, —CF 3 , —OCF 3 , —OR 8 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 8 heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —NHS(═O) 2 R 8 , —S(═O) 2 N(R 9 ) 2 , —N(R 9 )S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 8 , —N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —N(R 9 )C(═O)N(R 9 ) 2 , —N(R 9 )C(═O)OR 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —OC(═O)N(R 9 ) 2 , —CON(R 9 ) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 1 R 8 ; each R 8 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; and each R 9 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl, or pharmaceutically acceptable salt thereof.