Patent ID: 8030501

Claim:
A process for the production of an optically active 3-amino nitrogen-containing compound represented by the following formula (2); wherein, R 1 represents an alkyl group having 1 to 20 carbon atoms which may have a substituent, a cycloalkyl group having 3 to 20 carbon atoms which may have a substituent, an alkenyl group having 2 to 20 carbon atoms which may have a substituent, an aralkyl group having 7 to 20 carbon atoms which may have a substituent, an aryl group having 6 to 20 carbon atoms which may have a substituent, a heteroaryl group having 3 to 20 carbon atoms which may have a substituent, a hydroxyl group, an alkyloxy group having 1 to 20 carbon atoms, an aryloxy group having 6 to 20 carbon atoms, an aralkyloxy group having 7 to 20 carbon atoms, or a protecting group of an amino group; * represents an asymmetric carbon atom; n represents an integer of 1 to 3; and R 2 is an amino group, a methylamino group, an ethylamino group or a dimethylamino group, in which the position 3 is sterically inverted from the starting material, the process comprising allowing an optically active 3-substituted nitrogen-containing compound represented by the following formula (1); wherein, *, R 1 and n are as defined above; and L represents a leaving group, to react with ammonia, methylamine, ethylamine or dimethylamine in the presence of water, wherein the amount of water used is 0.1 to 10 times by weight on the weight of ammonia, methylamine, ethylamine, or dimethylamine, and wherein the reaction with ammonia, methylamine, ethylamine or dimethylamine is carried out at a temperature of less than 100° C., under a pressure of less than 10 barr.