Patent ID: 8679498

Claim:
A human engineered anti-N3pGlu Aβ monoclonal antibody or antigen-binding fragment thereof, comprising a light chain variable region (LCVR) and a heavy chain variable region (IICVR), wherein said LCVR comprises LCDR1, LCDR2, and LCDR3 polypeptides and HCVR comprises HCDR1, HCDR2, and HCDR3 polypeptides which are selected from the group consisting of: a) (SEQ ID NO: 3) LCDR1 is KSSQSLLYSRGKTYLN, (SEQ ID NO: 4) LCDR2 is AVSKLDS, (SEQ ID NO: 5) LCDR3 is VQGTHYPFT, (SEQ ID NO: 6) HCDR1 is GYDFTRYYIN, (SEQ ID NO: 8) HCDR2 is WINPGSGNTKYNEKFKG, and (SEQ ID NO: 9) HCDR3 is EGITVY; b) (SEQ ID NO: 3) LCDR1 is KSSQSLLYSRGKTYLN, (SEQ ID NO: 4) LCDR2 is AVSKLDS, (SEQ ID NO: 5) LCDR3 is VQGTHYPFT, (SEQ ID NO: 7) HCDR1 is GYTFTRYYIN, (SEQ ID NO: 8) HCDR2 is WINPGSGNTKYNEKFKG, and (SEQ ID NO: 10) HCDR3 is EGTTVY; c) (SEQ ID NO: 3) LCDR1 is KSSQSLLYSRGKTYLN, (SEQ ID NO: 4) LCDR2 is AVSKLDS, (SEQ ID NO: 5) LCDR3 is VQGTHYPFT, (SEQ ID NO: 40) HCDR1 is GYTFTDYYIN, (SEQ ID NO: 8) HCDR2 is WINPGSGNTKYNEKFKG, and (SEQ ID NO: 41) HCDR3 is EGETVY; d) (SEQ ID NO: 3) LCDR1 is KSSQSLLYSRGKTYLN, (SEQ ID NO: 35) LCDR2 is AVSKLGS, (SEQ ID NO: 5) LCDR3 is VQGTHYPFT, (SEQ ID NO: 7) CDR1 is GYTFTRYYIN, (SEQ ID NO: 8) HCDR2 is WINPGSGNTKYNEKFKG, and (SEQ ID NO: 10) HCDR3 is EGTTVY; and e) (SEQ ID NO: 45) LCDR1 is KSTRSLLYSRSKTYLN, (SEQ ID NO: 4) LCDR2 is AVSKLDS, (SEQ ID NO: 5) LCDR3 is VQGTHYPFT, (SEQ ID NO: 40) HCDR1 is GYTFTDYYIN, (SEQ ID NO: 8) HCDR2 is WINPGSGNTKYNEKFKG, and (SEQ ID NO: 46) HCDR3 is EGVTVY.