Patent ID: 8263743

Claim:
An isolated antigen-binding polypeptide that binds specifically to TL1A, comprising: (a) a humanized heavy chain variable region comprising: (1) a CDR-H1 comprising the amino acid sequence of TSNMGVV (SEQ ID NO:7); (2) a CDR-H2 comprising the amino acid sequence of HILWDDREYSNPALKS (SEQ ID NO:8); and (3) a CDR-H3 comprising the amino acid sequence of MSRNYYGSSYVMDY (SEQ ID NO:9); and (b) a humanized light chain variable region comprising: (1) a CDR-L1 comprising the amino acid sequence of SASSSVNYMH (SEQ ID NO:35); (2) a CDR-L2 comprising the amino acid sequence of STSNLAS (SEQ ID NO:36); and (3) a CDR-L3 comprising the amino acid sequence of HQWNNYGT (SEQ ID NO:37).