Patent ID: 7807700

Claim:
A compound of the general formula (III): wherein: R 5 is selected from C 3-10 -cycloalkyl and aryl; wherein any aryl or cycloalkyl is optionally independently substituted by one or more halogen, halo-C 1 -C 8 -alkyl, HO—C 1 -C 8 -alkyl, R 8 R 9 N—C 1 -C 8 -alkyl, C 1 -C 8 -alkyl-OR 10 , —OR 10 , (C 3 -C 10 )-cycloalkyl or C 1 -C 8 -alkyl-sulfonyl; R 6 is C 1-8 -alkyl; R 7 is C 1-8 -alkyl; wherein alkyl is optionally substituted by one or more of, —C 1 -C 8 -alkyl, —OH, —OR 10 , C 1 -C 8 -alkyl-SO 2 —, —SO 2 -aryl, —C(O)—(CR 8 R 9 ) n -carbamate, —C(O)—O—C 1 -C 8 -alkyl, —C(O)—C 1 -C 8 -alkyl, —C(O)—(CR 8 R 9 ) n —C(O)—NR 8 R 9 , —C(O)—(CR 8 R 9 ) n —NR 8 —C(O)—C 1 -C 8 -alkyl, —C(O)—(CR 8 R 9 ) n —NR 8 R 9 , —C(O)—C 3 -C 10 -cycloalkyl, —C(O)-aryl, —C(O)—(CR 8 R 9 ) n -heterocyclyl, —C 1 -C 8 alkyl-OR 8 , —C(O)-halo-C 1 -C 8 -alkyl or —C(O)—(CR 8 R 9 ) n -aryl, wherein any aryl, alkyl, cycloalkyl, or heterocyclyl is optionally independently substituted by one or more C 1-8 -alkyl, aryl, halogen, —NR 10 R 10 , C 1 -C 8 -haloalkyl, HO—C 1 -C 8 -alkyl, R 8 R 9 N—C 1 -C 8 -alkyl, C 1 -C 8 -alkyl-OR 10 , —OR 10 , (C 3 -C 10 )-cycloalkyl or C 1 -C 8 -alkyl-sulfonyl, —O—(CR 8 R 9 ) n -heterocyclyl, —O—(CR 8 R 9 ) n —C(O)—NR 8 R 9 , —O—(CR 8 R 9 ) n —NR 8 R 9 , —Y—(CR 8 R 9 ) n —NR 8 —C(O)—C 1 -C 8 -alkyl, —Y—(CR 8 R 9 ) n -heterocyclyl, —O—(CR 8 R 9 ) n —NR 8 R 9 , C 1 -C 8 -alkyl-SO 2 , or —O—(CR 8 R 9 ) n —N—C(O)-heterocyclyl wherein n is 0-5, Y is NR 10 , O or S; wherein R 8 and R 9 are each independently selected from hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, —NR 10 R 10 , —S—(C 1 -C 8 )alkyl, aryl and heterocyclyl; any alkyl, alkoxy, heterocyclyl or aryl may be substituted with one to three substituents selected from -halo, unsubstituted C 1 -C 8 alkyl, unsubstituted C 1 -C 8 alkoxy, unsubstituted C 1 -C 8 thioalkoxy and unsubstituted aryl(C 1 -C 4 )alkyl; wherein R 10 is independently selected from hydrogen, C 1 -C 8 alkyl, aryl-C 1 -C 8 alkyl, C 1 -C 8 alkoxy, —S—(C 1 -C 8 )alkyl, heterocyclyl and aryl; any alkyl, heterocyclyl or aryl may be substituted with one to three substituents selected from -halo, unsubstituted C 1 -C 8 alkyl, unsubstituted C 1 -C 8 alkoxy, unsubstituted C 1 -C 8 thioalkoxy and unsubstituted aryl(C 1 -C 4 )alkyl; or a pharmaceutically acceptable salt, tautomer, optical isomer, or N-oxide thereof, with the proviso that: when R 6 ═R 7 ═methyl, then R 5 is not phenyl or 4-iodophenyl.