Patent ID: RE39849

Claim:
A method of identifying a modulator of CCX CKR activity, comprising: (a) contacting a cell expressing a CCX CKR polypeptide with a test compound in the presence of a chemokine selected from the group consisting of ELC (EBI-1-ligand chemokine), SLC (secondary lymphoid organ chemoking), TECK (thymus expressed chemokine), BLC (B-lymphocyte chemoattractant), CTACK (cutaneous T cell attracting chemokine), mMIP-1γ (murine macrophage inflammatory protein-1γ), or vMIPII (viral macrophage inflammatory protein II), wherein the CCX CKR polypeptide comprises an amino acid sequence selected from the group consisting of: (i) an amimo sequence that has at least 90% sequence identity to SEQ ID NO:2, and (ii) a fragment of the amino acid sequence of (i); and the CCX CKR polypeptide separately can specifically bind at least two of the chemokines listed in (a) in the absence of the test compound; and (b) detecting modulation of a biological activity in the presence of the test compound, wherein modulation of the biological activity indicate that the test compound is a modulator of CCX CKR activity.