Patent ID: 7713538

Claim:
An intravascular stent comprising a metal body having a coating comprising a polymer and a restenosis inhibiting agent, wherein the restenosis inhibiting agent is a sparingly water soluble matrix metallo-proteinase inhibitor (MMPI) and the polymer in the coating is a cross-linked amphiphilic polymer formed from an ethylenically unsaturated zwitterionic monomer comprising a hydrophilic zwitterionic group; an ethylenically unsaturated hydrophobic monomer comprising a pendant hydrophobic group; and an ethylenically unsaturated reactive monomer comprising a pendant reactive group capable of forming intermolecular cross-linkers, wherein the zwitterionic monomer has the general formula I: YBX I wherein B is a straight or branched alkylene, alkyleneoxaalkylene or alkylene oligo-oxaalkylene chain optionally containing one or more fluorine atoms or, if X or Y contains a terminal carbon atom bonded to B, a valence bond; X is a zwitterionic group; and Y is an ethylenically unsaturated polymerisable group selected from CH 2 ═C(R)CH 2 O—, CH 2 ═C(R)CH 2 OC(O)—, CH 2 ═C(R)OC(O)—, CH 2 ═C(R)O—, CH 2 ═C(R)CH 2 OC(O)N(R 1 )—, R 2 OOCCR═CRC(O)O—, RCH═CHC(O)O—, RCH═C(COOR 2 )CH 2 C(O)O—, wherein: R is hydrogen or a C 1 -C 4 alkyl group; R 1 is hydrogen or a C 1 -C 4 alkyl group or R 1 is —B—X where B and X are as defined above; R 2 is hydrogen or a C 1-4 alkyl group; and K is a group selected from —(CH 2 ) p OC(O)—, —(CH 2 ) p C(O)O—, —(CH 2 ) p OC(O)O—, —(CH 2 ) p NR 3 —, —(CH 2 ) p NR 3 C(O)—, —(CH 2 ) p C(O)NR 3 —, —(CH 2 ) p NR 3 C(O)O—, —(CH 2 ) p OC(O)NR 3 , —(CH 2 ) p NR 3 C(O)NR 3 — (in which the groups R 3 are the same or different), —(CH 2 ) p O—, —(CH 2 ) p SO 3 —, or, optionally in combination with B, a valence bond; p is from 1 to 12; and R 3 is hydrogen or a C 1 -C 4 alkyl group.