Patent ID: 7202252

Claim:
A compound of formula (I): wherein: A is a 5- or 6-membered heteroaromatic ring containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S; R 2 is of the formula (i): (CH 2 )r—A′—R 4 (i) wherein: A′ is a 6-membered aromatic ring or heteroaromatic ring containing 1 to 4 nitrogen atoms; r is an integer ranging from 1 to 20; R 4 is selected from the group consisting of H; NH 2 ; (CH 2 ) s OH, wherein s is an integer ranging from 1 to 8; R 14 COOH, wherein R 14 is an alkylene or alkylidene group having 1 to 8 carbon atoms; halo, NHR 8 , NR 8 R 9 , NHCOR 8 , NR 8 COR 9 , SO 3 H and PO 3 H 2 ; R 3 is selected from the group consisting of H, NH 2 , R 15 COOH, wherein R 15 is an alkylene or alkylidene group having 1 to 8 carbon atoms, and (CH 2 ) t OH, wherein t is an integer ranging from 1 to 8; halo, NHR 8 , NR 8 R 9 , NHCOR 8 , NR 8 COR 9 , SO 3 H and PO 3 H 2 ; q is an integer ranging from 1 to 8; and R 1 is a C 1 –C 8 alkanyl group, C 2 –C 8 -alkenyl- or C2–C 8 -alkynyl- group which is optionally substituted by —CN, —CH 2 NR 6 R 7 OH, —OR 8 , —NR 6 R 7 , —NHCOR 8 , NHCONR 6 R 7 , halogen, —OCOR 8 , —OCH 2 COOH, —OCH 2 COOR 8 , —SO 2 R 5 , —S—R 5 , —OCH 2 —CONR 6 R 7 , —OCH 2 CH 2 OH, —SO 2 —CH 2 —CH 2 —O—COR 8 , —OCH 2 —CH 2 —NR 6 R 7 , —SO 2 —CH 2 —CH 2 —OH, —CONHSO 2 R 8 , —CH 2 CONHSO 2 R 8 , —OCH 2 CH 2 OR 8 , —COOH, —COOR 8 , —CONR 6 R 7 , —CHO, —SR 8 , —SOR 8 , —SO 2 R 8 , —SO 3 H, —PO 3 H 2 , —SO 2 NR 6 R 7 , —OCH 2 —CH 2 OCOR 8 , —CH═NOH, —CH═NOR 8 , —COR 9 , —CH(OH)R 9 , —CH(OR 8 ) 2 , —CH═CH—R 10 , —OCONR 6 R 7 , R 5 is C 1 –C 4 -alkyl, optionally substituted by OH, OCOR 8 , NH 2 , NR 6 R 7 or NHCOR 8 , R 6 and R 7 are each independently hydrogen, an optionally substituted C 3-6 -cycloalkyl group, a branched or unbranched alkyl-, alkenyl- or alkynyl group having up to 10 carbon atoms, which may optionally be substituted by hydroxy, phenyl, substituted phenyl, amino, or it denotes —(CH 2 ) m —NHCOOR 8 wherein m=1, 2, 3 or 4; R 8 is hydrogen, C 1 –C 8 -alkyl or C 2 –C 8 -alkenyl or C 2 –C 8 -alkynyl optionally substituted with CO 2 H, a benzyl- or phenyl- group, which is optionally mono- or polysubstituted by OCH 3 ; R 9 is C 1 –C 8 -alkyl or C 2 –C 8 -alkenyl or C 2 –C 8 -alkynyl optionally substituted with CO 2 H, optionally substituted phenyl, optionally substituted benzyl, C 3 –C 6 -cycloalkyl, and R 10 is —COOR 8 , —CH 2 OR 8 , —CONR 6 R 7 , hydrogen, C 1 –C 3 -alkyl, optionally substituted phenyl, —CH 2 NR 6 R 7 ; and pharmaceutically acceptable salts, and prodrugs thereof.