Patent ID: 8796453

Claim:
A process for preparing a compound of Formula 4: wherein: R 1 is —H, —Cl or —F; R 2 is —H or —F; R 3 is —C 1-4 aliphatic optionally substituted with 1-5 occurrences of R 5 ; R 4 is —C 1-2 alkyl optionally substituted with 1-3 occurrences of R 5 ; or R 3 and R 4 are taken together to form a 3-7 membered carbocyclic or heterocyclic saturated ring optionally substituted with 1-5 occurrences of R 5 ; each R 5 is independently selected from halogen, —OCH 3 , —OH, —NO 2 , —NH 2 , —SH, —SCH 3 , —NHCH 3 , —CN, or unsubstituted —C 1-2 aliphatic, or two R 5 groups, together with the carbon to which they are attached, form a cyclopropyl ring; comprising the step of: ia) reacting a compound of Formula 1 with a hydrochloride salt of a compound Formula 2, in the presence of water, an organic solvent, a base, and a palladium catalyst selected from or any combination thereof, to generate a compound of Formula 3, and ii) deprotecting the compound of Formula 3 to generate the compound of Formula 4.