Patent ID: 7037891

Claim:
A method for modulating GRK-associated signal transduction in a subject in need thereof, comprising: administering to the subject an effective amount of a compound comprising a sequence selected from the group consisting of: (a) a sequence which is a continuous stretch of at least five amino acids present in GRK2 in positions 382–414 (HJ loop); (b) a variant of a sequence according to (a), wherein up to 20% of the amino acids of a native sequence have been replaced with a naturally or non-naturally occurring amino acid and/or up to 20% of the amino acids have their side-chains chemically modified and/or up to 20% of the amino acids have been deleted, provided that at least 50% of the amino acids present in the sequence of (a) are unaltered in the variant, and provided that the variant maintains the GRK-associated signal transduction property of the parent amino acid sequence of (a); (c) a sequence of any one of (a) to b, wherein at least one of the amino acids is replaced by the corresponding D-amino acid; and (d) a sequence being the sequence of any one of (a) to (c) in reverse order.