Patent ID: 7781487

Claim:
A compound of Formula (I): wherein: R 1 and R 2 taken together with the carbon atom to which both R 1 and R 2 are attached form cycloalkylene optionally substituted with one or two R b independently selected from alkyl, halo, alkylamino, dialkylamino, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, alkoxycarbonyl, and aryloxycarbonyl; wherein the aromatic or alicyclic ring in the groups attached to cycloalkylene is optionally substituted with one, two, or three substituents independently selected from alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxycarbonyl, alkoxy, hydroxy, haloalkoxy, halo, carboxy, alkoxycarbonyl, amino, monsubstituted amino, disubstituted amino, or acyl; R 3 is hydrogen or alkyl; R 5 is hydrogen or alkyl; R 6 is aryl, optionally substituted by one, two, or three R e independently selected from alkyl, halo, hydroxy, hydroxyalkyl, hydroxyalkoxy, alkoxy, alkoxyalkyl, alkoxyalkyloxy, haloalkyl, haloalkoxy, oxo, cyano, nitro, acyl, cycloalkyl, cycloalkylalkyl, carboxy, alkoxycarbonyl, alkylsulfonyl, aminosulfonyl, or aminoalkyl, and further where the aromatic or alicyclic ring in R e is optionally substituted with one, two or three R f independently selected from alkyl, alkoxy, haloalkyl, haloalkoxy, halo, hydroxy, carboxy, cyano, nitro, aryl or cycloalkyl; R 7 is haloalkyl; R 8 is hydrogen, alkyl, alkoxyalkyl or haloalkyl; R 22 is cycloalkyl, cycloalkylalkyl, aryl or aralkyl, wherein the aromatic or alicyclic ring in R 22 is optionally substituted with one, two, or three R d independently selected from alkyl, haloalkyl, alkoxy, hydroxy, haloalkoxy, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryl, heteroaryl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, amino, monsubstituted amino, disubstituted amino, or acyl; Y is -alkylene-, wherein the alkylene group is optionally substituted with one to six fluoro atoms; and Z is a direct bond or -alkylene-, wherein the alkylene portion is optionally substituted with one to six fluoro atoms; or, a pharmaceutically acceptable salt thereof.