Patent ID: 8900431

Claim:
An analyte sensor system comprising: a glucose sensor comprising: at least one electrode having an electroactive surface; optionally an interference layer in contact with at least a portion of the electroactive surface; and an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output; wherein sensor break-in is about 30 minutes or less immediately following deployment; wherein the hydrophilic polymer of the hydrophilic polymer-enzyme composition comprises a material selected from the group consisting of poly-N-vinylpyrrolidone, poly-N-vinyl-3-ethyl-2-pyrrolidone, poly-N-vinyl-4,5-dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N—N-dimethylacrylamide, polyacrylamide, and copolymers thereof; and a catheter configured to be inserted into a vascular system of a subject, the catheter having an outer wall and comprising one or more ports formed in the outer wall; wherein the sensor is positioned at the one or more of the ports.