Patent ID: 7049307

Claim:
A compound of formula (I), or a therapeutically acceptable salt or prodrug thereof, wherein A is selected from the group consisting of —C(O)—, —S(O)—, —S(O) 2 —, —C(═NR a )— and —C(═S)—; B is a bond or is selected from the group consisting of alkylene, alkenyl, carbonylalkyl, cycloalkyl, —NR b — and —NR b -alkyl; D is a bond or is selected from the group consisting of alkylene, aryl, arylalkyl, heterocycle and heterocyclealkyl; E is selected from the group consisting of alkyl, alkyl-C(O)—, alkyl-C(O)—NH—, alkyl-NH—, alkyl-NH—C(O)—, alkyl-NH—S(O) 2 —, alkoxy, alkyl-S—, alkyl-S(O) 2 —, alkyl-S(O) 2 —NH—, aryl, aryl-C(O)—, aryl-C(O)—NH—, aryl-C═N—O—, aryl-NH—, aryl-NH—C(O)—, aryl-NH—S(O) 2 —, aryloxy, aryl-S—, aryl-S-alkyl-C(O)—, aryl-S(O) 2 —, aryl-S(O) 2 —NH—, arylalkyl-C(O)—, arylalkyl-C(O)—NH—, arylalkyl-NH—, arylalkyl-NH—C(O)—, arylalkyl-NH—S(O) 2 —, arylalkoxy, arylalkyl-S—, arylalkyl-S(O) 2 —, arylalkyl-S(O) 2 —NH—, cycloalkyl, cycloalkyl-C(O)—, cycloalkyl-C(O)—NH—, cycloalkyl-NH—, cycloalkyl-NH—C(O)—, cycloalkyl-NH—S(O) 2 —, cycloalkoxy, cycloalkyl-S—, cycloalkyl-S(O) 2 —, cycloalkyl-S(O) 2 —NH—, cycloalkenyl, cycloalkenylalkyl, cycloalkenyl-C(O)—, cycloalkenyl-C(O)—NH—, cycloalkenyl-NH—, cycloalkenyl-NH—C(O)—, cycloalkenyl-NH—S(O) 2 —, cycloalkenyloxy, cycloalkenyl-S—, cycloalkenyl-S(O) 2 —, cycloalkenyl-S(O) 2 —NH—, heterocycle, heterocycle-C(O)—, heterocycle-C(O)—NH—, heterocycle-NH—, heterocycle-NH—C(O)—, heterocycle-NH—S(O) 2 —, heterocycle-O—, heterocycle-S—, heterocycle-S(O) 2 —, heterocycle-S(O) 2 —NH—, heterocycle-alkyl-C(O)—, heterocycle-alkyl-C(O)—NH—, heterocycle-alkyl-NH—, heterocycle-alkyl-NH—C(O)—, heterocycle-alkyl-NH—S(O) 2 —, heterocycle-alkyl-O—, heterocycle-alkyl-S—, heterocycle-alkyl-S(O) 2 — and heterocycle-alkyl-S(O) 2 —NH—; R 1 is selected from the group consisting of hydrogen and alkyl; R 2 is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy; R 3 is R c R d N—; R 4 is selected from the group consisting of hydrogen and alkyl, or R 4 and R c taken together with any intervening atoms form a heterocycle; each occurrence of R 5 is independently selected from the group consisting of hydrogen and alkyl; R a is selected from the group consisting of hydrogen and alkyl; R b is selected from the group consisting of hydrogen and alkyl, or R b and R 1 taken together with any intervening atoms form a heterocycle; R c and R d are each independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkenylalkyl, heterocycle, heterocycle-alkyl and hydroxyalkyl, or R c and R d taken together with any intervening atoms form a heterocycle; Z is selected from the group consisting of hydrogen, alkyl and halogen; and m is 1, 2 or 3; provided that: if B is NR b —, NR b -alkyl or —O—, then D is selected from the group consisting of alkyl, aryl, arylalkyl, heterocycle and heterocyclealkyl.