Patent ID: 7850995

Claim:
A method of preparing a stable bioadhesive nanoparticulate composition comprising: (a) combining active agent droplets, wherein the active agent is in a liquid state at or near room temperature, with an emulsifying agent and a liquid non-solvent; (b) emulsifying the resultant mixture to produce an emulsion of active agent droplets dispersed in the liquid non-solvent; and (c) adding at least one cationic surface stabilizer for a time and under conditions sufficient for the cationic surface stabilizer to adsorb to the surface of the active agent liquid droplets to form a stable nanoparticulate composition, wherein the cationic surface stabilizer is in an amount effective to cause nanoparticles of the stable bioadhesive nanoparticulate composition to adhere to a biological surface, wherein: (i) the active agent droplets are insoluble within said non-solvent; (ii) the active agent droplets have an effective average particle size of less than about 4000 nm; and (iii) the nanoparticulate composition adsorbs to a biological surface, and (iv) the composition does not comprise a phospholipid.