Patent ID: 7772233

Claim:
A compound of Formula (I), or a tautomer or pharmaceutically acceptable salt thereof, wherein: Het is: wherein: * is the connecting position; W is selected from: 1) heteroaryl containing 1-4 heteroatoms or heterocycloalkyl containing 1-4 heteroatoms, wherein the heteroaryl or the heterocycloalkyl represented by W is optionally substituted by 1 to 5 substituents R 11 ; and 2) aryl, halogen, C 1 -C 10 -alkyl-OR 6 , C 1 -C 10 -alkyl-NR 7 R 8 , —C═NNR 6 R 7 , —C═NOR 7 , C 1 -C 10 alkyl(NR 7 )(NR 7 R 8 ), —C(O)R 6 , —C(O)OR 6 , —C(O)NR 7 R 8 , —C(O)NR 7 OR 6 , —C(O)(C 3 -C 10 -cycloalkyl), —C(O)(C 1 -C 10 -alkyl), —C(O)(aryl), —C(O)NR 7 (C 1 -C 10 -alkyl)heterocycloalkyl, —C(O)(heteroaryl), —C(O)(heterocycloalkyl), —CN, —C(O)NR 7 NR 8 R 6 , —C(O)C(O)R 6 , —NR 7 R 8 , —C(O)CR 6 R 7 C(O)R 8 , —NR 7 C(O)R 8 , —NRC(O)NR 7 R 8 or —C(O)NR 7 NR 8 C(O)R 6 ; R 1 and R 9 are independently selected from: hydrogen, halogen, cyano, azido, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 3 -C 10 -cycloalkyl, aryl, heteroaryl, heterocycloalkyl, C 1 -C 4 -alkyl-C(O)OR 6 , C 1 -C 4 -alkyl-OR 6 , C 1 -C 4 -alkyl-C(O)NR 7 R 8 , —C(O)OR 6 , —C(O)R 6 , —NR 7 C(O)OR 6 , —OC(O)R 6 , —NR 7 R 8 , —SR 6 , and —NR 7 S(O) 2 R 6 , R 2 and R 3 are independently halogen; R 4 and R 5 are independently selected from: hydrogen, halogen, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy R 6 , R 7 and R 8 are independently selected from hydrogen, C 1 -C 10 -alkyl, C 3 -C 10 -cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, C 1 -C 4 -alkyl-C(O)OR′, C 1 -C 4 -alkyl-OR′, C 1 -C 4 -alkyl-(heterocycloalkyl), C 1 -C 4 -alkyl-diol, and C 1 -C 4 -alkyl-C(O)NR′R″; or R 7 and R 8 can be taken together with the atom to which they are attached to form a 6-membered heteroaryl or heterocycloalkyl ring, with 1 or 2-nitrogen atoms and optionally an oxygen atom; R 10 is selected from hydrogen, halogen or C 1 -C 6 -alkyl; R 11 is selected from hydrogen, C 1 -C 6 -alkyl, —OR 6 , —NR 7 R 8 , —SR 6 , and —NR 7 S(O)(O)R′; and R′ and R″ are independently selected from hydrogen, C 1 -C 6 -alkyl and aryl.