Patent ID: 7652764

Claim:
A method for reconstructing a fluorescence-enhanced optic tomography image to examine a heterogeneous object of any shape comprising fluorophores and disposed in air, said method comprising: defining a dummy volume containing the object, selecting relevant sources and detectors, assimilated to points of the surface of the object, defining relevant Green's functions, in said dummy volume, each associated with a selected relevant source and/or a selected relevant detector, each relevant Green's function comprising a first spatial coordinate associated with a selected relevant source and corresponding to a point of a first face of the object, and/or a second spatial coordinate associated with a selected relevant detector and corresponding to a point of a second face of the object, opposite the first face, adapting the relevant Green's functions to the heterogeneity of the dummy volume, illuminating the first face of the object with a fluorophore excitation light from sources including the selected relevant sources, detecting a light emitted by the second face of the object by a matrix of detectors, the detectors including the selected relevant detectors, and determining the fluorophore distribution using a processor by said relevant Green's functions according to signals detected by the detectors.