Patent ID: 8828942

Claim:
A composition comprising a peptide or polypeptide comprising the amino acid sequence (X 1 ) n X 2 X 3 X 4 X 5 GX 6 P(X 7 ) m (SEQ ID NO: 78) (Formula I), wherein X 1 is any amino acid residue, X 2 is an amino acid residue selected from the group consisting of lysine (K), arginine (R), alanine (A) and histidine (H), X 3 is an amino acid residue selected from the group consisting of asparagine (N), glutamine (Q), serine (S), glycine (G) and alanine (A), X 4 is an amino acid residue selected from the group consisting of glutamic acid (E), aspartic acid (D) and alanine (A), X 5 is an amino acid residue selected from the group consisting of glutamic acid (E) and aspartic acid (D), X 6 is an amino acid residue selected from the group consisting of alanine (A) and tyrosine (Y), X 7 is any amino acid residue, n and m, independently, are 0 or an integer of more than 0, and wherein the amino acid sequence according to Formula I is not identical with, or does not comprise the 7-mer polypeptide fragment of alpha-synuclein having the amino acid sequence KNEEGAP (SEQ ID NO: 139) and wherein the peptide or polypeptide does not comprise the amino acid sequence of formula I wherein X 2 is K, X 3 is G, X 4 is E, X 5 is E, X 6 is Y and X 7 is P, said at least one peptide or polypeptide having a binding capacity to an antibody which is specific for an epitope of alpha-synuclein comprising the amino acid sequence KNEEGAP (SEQ ID NO: 139), suitable for use in preventing and/or treating synucleinopathies.