Patent ID: 8343980

Claim:
A method of treating or lessening the severity of a disease, disorder, or condition selected from arthritis, migraine, cluster headaches, epilepsy or epilepsy conditions, osteoarthritis pain, head pain or neck pain, comprising the step of administering to said patient an effective amount of a compound of formula IA-ii: or a pharmaceutically acceptable salt thereof, wherein: a) the ring formed by R 1 and R 2 taken together is selected from: and the ring formed by R 1 and R 2 taken together, are each optionally and independently substituted at one or more substitutable carbon or nitrogen atoms with z independent occurrences of —R 4 , wherein z is 0-5; b) wherein z is 0-5, and R 4 groups, when present, are each independently halogen, CN, NO 2 , —N(R′) 2 , —CH 2 N(R′) 2 , —OR′, —CH 2 OR′, —SR′, —CH 2 SR′, —COOR′, —NRCOR′, —CON(R′) 2 , —OCON(R′) 2 , COR′, —NHCOOR′, —SO 2 R′, —SO 2 N(R′) 2 , or an optionally substituted group selected from C 1 -C 6 aliphatic, aryl, heteroaryl, cycloaliphatic, heterocycloaliphatic, arylC 1 -C 6 alkyl, heteroarylC 1 -C 6 alkyl, cycloaliphaticC 1 -C 6 alkyl, or heterocycloaliphaticC 1 -C 6 alkyl; c) wherein x is 1, and R 3 is an optionally substituted group selected from C 1 -C 6 aliphatic d) wherein y is 0; and e) R 5a is —OH; and f) each occurrence of R′ is independently hydrogen or an optionally substituted C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur.