Patent ID: 6927290

Claim:
A method for producing an amide compound of formula (4); wherein R 1 denotes a hydrogen atom, an optionally substituted saturated or unsaturated hydrocarbyl group, or an optionally substituted hetero ring, R 3 and R 4 independently denote a hydrogen atom, an optionally substituted saturated or unsaturated hydrocarbyl group, an optionally substituted hetero ring, a protective group for an amino group, or R 3 represents a group of formula: —OR 30 , or —NR 30 R 31 , wherein R 30 represents an optionally substituted alkyl group, or an optionally substituted aryl group and R 31 represents a hydrogen atom or an optionally substituted aryl group, and R 3 and R 4 may be bonded to form a ring, which comprises reacting the mixed acid anhydride of formula (1) R 1 C(O)OY(O) n (R 2 ) p (1) wherein R 1 is the same as defined above, and R 2 , Y, n and p are the same as defined below, with an amine of formula (5); NHR 3 R 4 (5) wherein R 3 and R 4 independently denote the same as described above, and wherein the mixed acid anhydride of formula (1) is prepared by adding a carboxylic acid of formula (2); R 1 COOH (2) wherein R 1 is the same as defined above; and N-methylmorpholine to a solution of a carboxylic acid activating agent of formula (3); (R 2 ) p Y(O) n X (3) wherein R 2 denotes an optionally substituted alkyl group, an optionally substituted aryl group, an optionally substituted chain or cyclic alkoxy group, or an optionally substituted aryloxy group, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, X denotes a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group or a group of formula: (R 2 ) p Y(O) n O—, wherein R 2 is the same as defined above, n and p are an integer of 1 or 2; and when Y is a carbon atom, n=1 and p=1, when Y is a phosphorous atom, n=1 and p=2, and when Y is sulfur atom, n=2 and p=1 and R 2 denotes an optionally substituted alkyl or aryl group.