Patent ID: 8492118

Claim:
An isolated soluble fusion protein complex comprising at least two soluble fusion proteins, wherein the first fusion protein comprises (a) a first single chain T-cell receptor (scTCR) covalently linked to (b) interleukin-15 (IL-15) polypeptide; and the second fusion protein comprises (c) a second scTCR covalently linked to (d) soluble interleukin-15 receptor alpha (IL-15Ra) polypeptide; wherein the IL-15 polypeptide of the first fusion protein binds to the soluble IL-15Ra polypeptide or of the second fusion protein to form a soluble fusion protein complex, and further wherein the first scTCR and the second scTCR comprise a TCR V-α chain covalently linked to a TCR V-β chain by a peptide linker sequence.