Patent ID: 8372876

Claim:
A method for improving memory in mammals including humans comprising: administering an effective amount of a melatonin receptor antagonist composition in a dose range between about 1 mg/kg to about 1000 mg/kg to an animal, including a human, within about an hour of commencing a cognitive learning activity and/or prior to going to sleep after engaging in a cognitive learning activity, where the effective amount is sufficient to reduce the inhibitory action of melatonin on long-term memory formation improving long-term memory formation and improving learned activity performance and outcomes, where the melatonin receptor composition comprises luzindole, K-185, or a mixture of luzindole and K-185, and where the cognitive learning activity includes studying for examinations, training of canines for use in civil and military applications, training of a task, where memory of data concerning the task is critical, training for a sport, training for military operations, training for police operations, training for police investigations, or in any other application where memory retention plays a role in successful performance of the task.