Patent ID: 7323480

Claim:
A compound having the formula: wherein Ar 1 is phenyl, which is optionally substituted with from one to five R 7 substituents independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, and —OR 2 ; Ar 2 is phenyl, which is optionally substituted with from one to four R 8 substituents independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, and —OR 2 ; L is a member selected from the group consisting of —CH 2 S— and —CH 2 O—; K is a member selected from the group consisting of a covalent bond and —OCH 2 — Z is CO 2 R 6 ; R 1 is selected from the group consisting of H and (C 1 -C 8 )alkyl; each R 2 and R 3 is a member independently selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, —X 3 OR 9 , aryl, aryl(C 1 -C 4 )alkyl, and heteroaryl, or optionally, if both present on the same substituent, may be joined together to form a three- to eight-membered ring system; R 6 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, —X 4 OR 2 , —X 4 NR 2 R 3 , (C 2 -C 8 )alkenyl, (C 3 -C 7 )cycloalkyl, heterocyclyl, aryl (C 1 -C 4 )alkyl; and aryl(C 2 -C 8 )alkenyl; R 9 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, and heteroaryl; each X 3 and X 4 is a member independently selected from the group consisting of (C 1 -C 4 ) alkylene, (C 2 -C 4 )alkenylene, and (C 2 -C 4 )alkynylene; and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof.