Patent ID: 8637672

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer, or tautomer thereof, wherein X is halogen; Z1 and Z2 are CR2; Z3 is CH; each R1 is independently and individually halogen, H, C1-C6 alkyl, branched C3-C7 alkyl, C3-C7 cycloalkyl, or —CN; each R2 is individually and independently H, halogen, C1-C6 alkyl, or cyano; R3 is —C(O)R4, —C(O)—C6-C10-aryl, —C(O)—C4-C6-heterocyclyl, or —C(O)—C5-C6-heteroaryl, wherein aryl is phenyl, naphthyl, tetrahydronaphthyl, indenyl or indanyl; and with the proviso that when R3 is —C(O)—C4-C6-heterocyclyl, the heterocyclyl does not have a N bonding hand to —C(O); R4 is C3-C8 cycloalkyl, C1-C7 alkyl, —(CH 2 ) p —CN, —(CH 2 ) p —OR6, —(CH 2 ) p —NR6(R7), —(CH 2 ) p —SO 2 —C1-C6-alkyl, —(CH 2 ) p —C6-C10-aryl, —(CH 2 ) p —C5-C6-heteroaryl, or —(CH 2 ) p —C4-C6-heterocyclyl, wherein each alkyl or alkylene is optionally substituted with one or two C1-C6 alkyl; and aryl is phenyl, naphthyl, tetrahydronaphthyl, indenyl or indanyl; each R6 and R7 is individually and independently H, C1-C6 alkyl, or C3-C8 branched alkyl; each cycloalkyl, aryl, heteroaryl and heterocyclyl is independently substituted with —(R25) m ; each R25 is individually and independently C1-C6 alkyl, branched C3-C8 alkyl, halogen, —(CH 2 ) m —CN, —(CH 2 ) m —OR6, —(CH 2 ) m —NR6(R7), —(CH 2 ) m —SO 2 —C1-C6-alkyl, —(CH 2 ) m —C(O)NR6(R7), —(CH 2 ) m —C(O)—C4-C6-heterocyclyl, or —(CH 2 ) m —C4-C6-heterocyclyl, wherein each alkyl or alkylene is optionally substituted with one or two C1-C6 alkyl; each m is individually and independently 0, 1, 2, or 3; and p is 1, 2, or 3.