Patent ID: 7774057

Claim:
A gene regulatory system, comprising: a sensing circuit to sense one or more parameters indicative of an ischemic event; an ischemia detector, coupled to the sensing circuit, to detect an end of the ischemic event from the one or more parameters; a gene regulatory signal delivery device adapted to emit at least one gene regulatory signal that directly or indirectly regulates a regulatable transcriptional control element without inducing cardiac depolarization; and a controller coupled to the ischemia detector and the gene regulatory signal delivery device, the controller being a microprocessor-based control circuit including: a gene regulatory initiator adapted to initiate one or more cardiac protection biologic therapies in response to the detection of the end of the ischemic event, the one or more cardiac protection biologic therapies each including alternating signaling periods and non-signaling periods, the signaling periods each having a signaling duration during which the at least one gene regulatory signal is emitted, the non-signaling periods each having a non-signaling duration during which the at least one gene regulatory signal is not emitted, the gene regulatory initiator including a postconditioning initiator adapted to initiate a postconditioning cardiac biologic therapy of the one or more cardiac protection biologic therapies in response to expiration of a post-ischemia time interval that starts at the end of the ischemic event and ends after a predicted reperfusion period following the ischemic event has started; and a gene regulatory timer adapted to time the one or more cardiac protection biologic therapies.