Patent ID: 8585943

Claim:
A method for producing a batch of particles of a substance in a production arrangement, said particles having predetermined sizes, comprising the steps of: i) mixing within a spray nozzle and under flow conditions a stream of a solution in which the substance is dissolved or dispersed with a stream of a fluid, wherein the fluid stream is in a state selected from a subcritical state and a supercritical state and wherein the fluid stream is gaseous at room temperature and atmospheric pressure, to form a mixture, a ratio of volumetric flow velocities of the two streams being selected to promote nucleation and particle formation of the substance in the mixture, ii) passing said mixture in the form of a spray through a spray outlet of the nozzle into a particle collecting chamber, iii) separating and collecting within said chamber said particles having said predetermined sizes from said mixture, and iv) providing one or more make-up agents which influence the size characteristics of the particles obtained in the process to the fluid stream.