Patent ID: 7259143

Claim:
A method of treating a disease in a mammal said disease selected from the group consisting of psoriasis, leukemia, colon cancer, breast cancer, prostate cancer, multiple sclerosis, lupus, inflammatory bowel disease, Type I diabetes, host versus graft reaction, and rejection of organ transplants, comprising restricting calcium intake in the mammal's diet, and administering to said mammal orally, parenterally, or transdermally in an appropriate dosage schedule an effective amount of a bone calcium resorption inhibitor and a vitamin D compound, said vitamin D compound administered at a dosage sufficient to treat said disease, said dosage being sufficient to produce hypercalcemia absent the step of administering the bone calcium absorption inhibitor and the step of restricting calcium, said vitamin D compound selected from the group consisting of a compound having the formula where R 6 and R 7 each represent hydrogen or taken together R 6 and R 7 represent a methylene group, R 8 represents hydrogen, hydroxy or a protected hydroxy, R 9 and R 10 may each independently represent hydrogen, alkyl, hydroxyalkyl, or fluoroalkyl, or R 9 and R 10 taken together may represent the group —(CH 2 ) x — where x is an integer from 2 to 5, the group —OY or ═R 11 R 12 where R 11 and R 12 , which may be the same or different, are each selected from hydrogen, alkyl, hydroxyalkyl and fluoroalkyl, or when taken together R 11 and R 12 represent the group —(CH 2 )x— where x is an integer from 2 to 5 and the group R is represented by the structure where the stereochemical center at carbon 20 may have the R or S configuration, and where Z is selected from Y, —OY, —CH 2 OY, —C≡CY and —CH═CHY, where the double bond may have the cis or trans geometry, and where Y is selected from hydrogen, methyl, —COR 5 and a radical of the structure: where m and n, independently, represent the integers from 0 to 5, where R 1 is selected from hydrogen, deuterium, hydroxy, protected hydroxy, fluoro, trifluoromethyl, and C 1-5 -alkyl, which may be straight chain or branched and, optionally, bear a hydroxy or protected-hydroxy substituent, and where each of R 2 , R 3 , and R 4 , independently, is selected from deuterium, deuteroalkyl, hydrogen, fluoro, trifluoromethyl and C 1-5 alkyl, which may be straight-chain or branched, and optionally, bear a hydroxy or protected-hydroxy substituent, and where R 1 and R 2 , taken together, represent an oxo group, or an alkylidene group, ═CR 2 R 3 , or the group —(CH 2 ) p —, where p is an integer from 2 to 5, and where R 3 and R 4 , taken together, represent an oxo group, or the group —(CH 2 ) q —, where q is an integer from 2 to 5, and where R 5 represents hydrogen, hydroxy, protected hydroxy, or C 1-5 alkyl and wherein any of the CH-groups at positions 20, 22, or 23 in the side chain may be replaced by a nitrogen atom, or where any of the groups —CH(CH 3 )—, —(CH 2 ) m —, —(CR 1 R 2 )— or —(CH 2 ) n — at positions 20, 22, and 23, respectively, may be replaced by an oxygen or sulfur atom.