Patent ID: 7083983

Claim:
An isolated peptide which binds to a DM2 protein, which peptide comprises no more than 15 amino acids, and comprises an amino acid motif comprising at least the eight consecutive amino acids from F to R 4 of the formula R 1 -X-F-X-R 2 -R 3 -W-X-X-R 4 (SEQ ID NO: 4) wherein R 1 is a proline (P), leucine (L), glutamic acid (E), cysteine (C) or glutamine (Q), X stands for any natural amino acid, R 2 is arginine (R), histidine (H), or aspartic acid (D), R 3 is histidine (H), phenylalanine (F) or tyrosine (Y), R 4 is phenylalanine (F), glutamine (Q) or leucine (L); and F is phenylalanine and W is tryptophan, and inhibits the binding of said DM2 protein to a p53 protein.