Patent ID: 8858975

Claim:
A stent comprising: a) a substrate including struts having a surface, wherein the surface includes a chromium oxide layer; b) a primer region free from drugs deposited on the surface, the primer region comprising a polymeric material with polar substituents or cationic groups; and c) a reservoir region comprising a polymer and a drug deposited on the primer region; wherein the polymeric material with polar substituents or cationic groups is selected from the group consisting of polyisocyanates, high amine content polymers, acrylates, polymers containing a high content of hydrogen bonding groups, inorganic polymers, and combinations thereof; wherein the high amine content polymers are selected from the group consisting of polyethyleneamine, polylysine, and combinations thereof; wherein the acrylates are selected from the group consisting of cyanoacrylates, and combinations thereof; wherein the polyisocyanates are selected from the group consisting of triisocyanurate, polymethylene polyphenyl isocyanate, polyester polyurethanes, and combinations thereof; wherein the polymers containing a high content of hydrogen bonding groups are selected from the group consisting of epoxy polymers cured by polyols and lewis acid catalysts, epoxy phenolics, epoxy-polysulfides, polyvinylalcohol-co-vinyl acetate polymers, resorcinol-formaldehydes, urea-formaldehydes, alkyd polyester resins, anhydride modified ethylene acrylate copolymers, anhydride modified ethylene vinyl acetate polymers, and combinations thereof; wherein the inorganic polymers are selected from the group consisting of (3-glycidoxypropyl)methyldiethoxysilane, tetra-iso-propyl titanate, tetra-n-butyl titanate, n-propyl zirconate and combinations thereof; and wherein the polymer of the reservoir region is selected from the group consisting of poly(hydroxyvalerate), poly(L-lactic acid), polycaprolactone, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, polyorthoesters, polyanhydrides, poly(glycolic acid), poly(D,L-lactic acid), poly(glycolic acid-co-trimethylene carbonate), polyphosphoesters, cyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), copoly(ether-esters), polyalkylene oxalates, polyphosphazenes, fibrin, fibrinogen, starch, collagen, hyaluronic acid, polyurethanes, silicones, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers, polyvinyl ethers, polyvinylidene halides, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics, polyvinyl esters, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, ethylene-vinyl acetate copolymers, Nylon 66, polycaprolactam, alkyd resins, polycarbonates, polyoxymethylenes, polyimides, epoxy resins, rayon, rayon-triacetate, cellulose, cellulose ethers, and combinations thereof.