Patent ID: 8563724

Claim:
A (+)-morphinan compound of Formula (II) or a pharmaceutically acceptable salt thereof: wherein: A is chosen from {—}OR 8 and {—}NR 8 R 9 ; R 1 is chosen from hydrocarbyl and substituted hydrocarbyl; R 3 , R 4 , R 8 , and R 9 are independently chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 5 and R 6 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {—}OH, {—}NH 2 , and {—}OR 7 ; R 7 is chosen from hydrocarbyl and substituted hydrocarbyl; Y is chosen from hydrogen, hydroxy, protected hydroxy, alkoxy, and acyloxy; Z is chosen from hydroxy, protected hydroxy, alkoxy, and acyloxy; and the dashed line between the carbon atoms at positions 7 and 8 represents a single bond or a double bond; provided, however: when A is {—}OH, {—}O(CO)CH 3 , {—}NH(CH 2 ) 2 OH, {—}NH(CO)CH 3 , or {—}NH 2 , then R 1 is other than methyl; when A is {—}OH, {—}NH(CH 2 ) 2 OH, or {—}NH(CO)CH 3 , then R 1 is other than {—}(CH 2 (CH)CH 2 ; when A is {—}OH, {—}NH(CH 2 ) 2 OH, {—}NH(CO)CH 3 , {—}NH 2 , or {—}NHCH 3 then R 1 is other than {—}CH 2 (cyclopropane); when A is {—}OH, then R 1 is other than {—}CH 2 (cyclobutane); when A is —OC(═O)R, then R is H or heterocyclo; and, when A is —NR′R″ and one of R′ or R″ is substituted alkyl, then the other of R′ or R″ is H.