Patent ID: 7550485

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: is phenyl or naphthyl U is N or O; R 1 and R 2 are, independently, H, OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, benzyloxy, phenyloxy, naphthyloxy, phenylethoxy, phenoxyethoxy, naphthylmethoxy, phenylcarbonylamino, phenylaminocarbonyl, nitro, trifluoromethoxy, nitrile, alkenyl, alkynyl, sulfoxide, sulfonyl, sulfonamido or phenyl; wherein each of the aryl groups appearing in said R 1 is optionally substituted with one or more substituents selected from OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, methylenedioxy, benzyloxy, phenyloxy, naphthyloxy, phenylethoxy, phenoxyethoxy, naphthylmethoxy, phenylcarbonylamino, phenylaminocarbonyl, nitro, trifluoromethoxy, nitrile, alkenyl, alkynyl, sulfoxide, sulfonyl, sulfonamido, and phenyl; or R 1 and R 2 together form methylenedioxy; R 3 and R 4 are, independently, H, (C 1 -C 6 )alkyl, benzyl (optionally substituted with one or more R 1 ), naphthylmethyl (optionally substituted with one or more R 1 ), phenyl(C 2 -C 6 )alkyl, heteroarylmethyl, cycloalkyl, cycloalkenyl, or cycloalkylmethyl, provided that, when U is O, one of R 3 and R 4 is absent; or when U is N, R 3 and R 4 , together with U, form a ring with 3 to 4 ring carbon atoms, or form a ring with 5 to 7 ring carbon atoms wherein 1 ring carbon atom can be optionally replaced with N, S, or O; R 5 is H, (C 1 -C 6 )alkyl, halo, or trifluoromethyl; R 6 and R 7 together form cyclohexyl; where R 6 and R 7 may be optionally substituted with R 5 or OH; or where R 6 and R 7 can form cyclohexyl fused onto a cyclohexane; and z is 0, 1, or 2.