Patent ID: 7645602

Claim:
An isolated host cell comprising a recombinant nucleic acid coding for a vitamin K epoxide reductase (VKOR), wherein the recombinant nucleic acid coding for the VKOR comprises a nucleotide sequence selected from the group consisting of: 1) the nucleotide sequence of SEQ ID NO:9; 2) a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO: 10; 3) a nucleotide sequence having at least 95% identity with the nucleotide sequence of SEQ ID NO:9 and that encodes a VKOR; 4) a nucleotide sequence that hybridizes with the complement of the nucleotide sequence of (1) or (2) above under stringent conditions as represented by hybridization conditions of 0.5M NaHPO 4 , 7% sodium dodecyl sulfate (SDS), 1mM EDTA at 65° C. and wash conditions of 0.1×SSC/0.1% SDS at 68° C. and that encodes a VKOR; 5) a nucleotide sequence that encodes an amino acid sequence having at least 95% identity with the amino acid sequence of SEQ ID NO: 10 and that encodes a VKOR; and 6) a nucleotide sequence that differs from the nucleotide sequence of(1), (2), (3), (4) or (5) above due to the degeneracy of the genetic code and that encodes a VKOR, and a recombinant nucleic acid coding for a vitamin K dependent protein, wherein both the recombinant VKOR and the recombinant Vitamin K dependent protein are expressed in said host cell.