Patent ID: 7005436

Claim:
A compound of formula I including enantiomers, diastereomers, salts and solvates thereof wherein mn and p are independently 0, 1, or 2, provided that the sum of m and p is 2; Q is NR 1 ; J is a bond or C 1-4 alkylene optionally substituted with one or more groups T 1a , T 2a or T 3a ; R 1 is selected from R 2 is aryl, which may be optionally independently substituted with one or more groups T 1 , T 2 or T 3 ; R 3 is R 5 is optionally substituted heteroaryl or (heteroaryl)alkyl wherein the hetero is pyrazine or pyridine, and either of these may be optionally independently substituted with one or more groups T 1c , T 2c or T 3c ; R 6 , R 7 , R 8 and R 8a are independently H, alkyl, hydroxy, alkoxy, aryloxy, (hydroxy)alkyl, (alkoxy)alkyl, (aryloxy)alkyl, (cyano)alkyl, (alkenyl)alkyl, (alkynyl)alkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, —C(O)R 9 , —CO 2 R 9 , —C(O)—NR 9 R 10 , or —NR 9 R 10 , any of which may be optionally independently substituted with one or more groups T 1d , T 2d or T 3d ; R 8b is H, alkyl, aryl, cyano, nitro, acyl or —SO 2 (alkyl) wherein the alkyl and aryl groups may be optionally independently substituted with one or more groups T 1d , T 2d or T 3d ; R 8c is H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, alkoxy or aryloxy, any of which may be optionally independently substituted with one or more groups T 1d , T 2d or T 3d ; R 9 and R 10 are independently H, alkyl, hydroxy, alkoxy, aryloxy, (hydroxy)alkyl (alkoxy)alkyl, (aryloxy)alkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, or (aryl)alkyl, any of which may be optionally independently substituted with one or more groups T 1f , T 2f or T 3f ; Z 1 is ═O; R x is one or more optional substituents attached to any available ring carbon atom, each of which is independently selected from T 1g , T 2g or T 3g ; T 1-1g , T 2-2g , and T 3-3g are independently (1) hydrogen or T 6 , where T 6 is (i) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, or (aryl)alkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) B group (i) or (ii) which is independently substituted by one or more of the following groups (2) to (13); (2) —OH or —OT 6 , (3) —SH or —ST 6 , (4) —C(O) t H, —C(O) t T 6 , or —O—C(O)T 6 , where t is 1 or 2; (5) —SO 3 H, —S(O) t T 6 , or S(O) t N(T 9 )T 6 , (6) halo, (7) cyano, (8) nitro, (9) -T 4 -NT 7 T 6 , (10) -T 4 -N(T 9 )-T 5 -NT 7 T 8 , (11) -T 4 -N(T 10 )-T 5 -T 6 , (12) -T 4 -N(T 10 )-T 5 -H, (13) oxo; T 4 and T 5 are independently (1) a single bond, (2) -T 11 -S(O) t -T 12 -, (3) -T 11 -C(O)-T 12 -, (4) -T 11 -C(S)-T 12 -, (5) -T 11 -O-T 12 -, (6) -T 11 -S-T 12 -, (7) -T 11 -O—C(O)-T 12 -, (8) -T 11 -C(O)—O-T 12 -, (9) -T 11 -C(═NT 9a )-T 12 -, or (10) -T 11 -C(O)—C(O)-T 12 -; T 7 , T 8 , T 9 , T 9a and T 10 (1) are independently hydrogen or a group provided in the definition of T 6 ; and T 11 and T 12 are independently (1) a single bond, (2) alkylene, (3) alkenylene, or (4) alkynylene.