Patent ID: 7579373

Claim:
A linear polyamine-bridged platinum compound having the general formula [(PtXYZ)-A-(Pt X′Y′Z′)], or salts thereof, where X, Y, Z, X′, Y′, and Z′ may be the same or different and are anionic groups, or neutral groups which may be substituted or unsubstituted; and A is a bridging polyamine having a general formula selected from the group consisting of H 2 N(CH 2 ) x NBB′(CH 2 ) y NH 2 where x ranges from 1 to 10 and y ranges from 1 to 10, or H 2 N(CH 2 ) x NBB′(CH 2 ) y NBB′(CH 2 ) x NH 2 where x ranges from 1 to 10 and y ranges from 1 to 10, where B and B′ are hydrogen or a labile blocking group and may be the same or different, and may be the same or different at each location, and where B′ may be present or absent, and wherein when said anionic groups or neutral groups of said linear polyamine-bridged platinum compound are in a 1,1/t,t configuration with respect to said bridging polyamine, said labile blocking group is not tBOC; and wherein i) said anionic groups are selected from the group consisting of halide, pseudohalide, substituted pseudohalide, sulphate, phosphate, phosphonate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, and substituted dicarboxylate; ii) said neutral groups are selected from the group consisting of ammonia, primary or secondary amines, a “dangling” diamine H 2 N(CH 2 ) n NBB′ where only the —NH 2 moiety is bound to platinum, pyridine, substituted pyridine, quinoline, imidazole, thiazole, pyrimidine, purine, acridine, pyrazole, benzimidazole, and benzothiazole; and for 1,1/c,c configurations, Y, Y′, Z and Z′ may be a chelating bidentate diamine; and iii) said labile blocking group is an amide protection group, with the proviso that when x =4, y =3, and at least two of X, Y, Z and X′, Y′, Z′ are NH 3, one of B or B′ is a labile protecting group.