Patent ID: 8557837

Claim:
A sinomenine derivative, or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein the sinomenine derivative has the following structure: wherein R 1 =H or R 10 CO; R 2 =H or R 10 CO; R 3 =R 11 O, R 12 S, R 13 R 14 N, OH, R 10 COO, or R 4 =H or R 16 R 17 R 18 Si; R 5 =R 11 O, OH, or CH 3 COO; R 6 =H or R 11 O; or R 5 and R 6 together form an oxo group; R 7 =H, halogen, or hydroxymethyl; R 8 =hydroxyl or H; R 9 =hydroxyl or H; or R 8 and R 9 together form an oxo group; R 10 =C 1-4 hydrocarbyl; R 11 =C 1-10 hydrocarbyl; R 12 =C 1-10 hydrocarbyl, a 5-membered or 6-membered aromatic ring that is unsubstituted or contains 1-3 substituents, a 5-membered or 6-membered nitrogen-containing heterocycle that is unsubstituted or contains 1-3 substituents, a 5-membered or 6-membered oxygen-containing heterocycle that is unsubstituted or contains 1-3 substituents, or a 5-membered or 6-membered sulfur-containing heterocycle that is unsubstituted or contains 1-3 substituents, wherein the substituent is C 1-10 hydrocarbyl, halogen, C 1-4 alkyl, or C 1-4 fluoroalkyl, nitro, cyano, methoxy, or hydroxyl group; R 13 =C 1-10 hydrocarbyl, a 5-membered or 6-membered aromatic ring that is unsubstituted or contains 1-3 substituents, a 5-membered or 6-membered nitrogen-containing heterocycle that is unsubstituted or contains 1-3 substituents, a 5-membered or 6-membered oxygen-containing heterocycle that is unsubstituted or contains 1-3 substituents, or a 5-membered or 6-membered sulfur-containing heterocycle that is unsubstituted or contains 1-3 substituents, wherein the substituent is C 1-10 hydrocarbyl, halogen, C 1-4 alkyl, or C 1-4 fluoroalkyl, nitro, cyano, C 1-4 alkoxy, or hydroxyl group; R 14 H or C 1-10 hydrocarbyl; or R 13 and R 14 together with the N atom, to which they are attached, form a 5-membered or 6-membered nitrogen-containing heterocycle that is unsubstituted or contains 1-3 substituents, wherein the substituent is halogen, C 1-4 alkyl, or C 1-4 fluoroalkyl, nitro, cyano, C 1-4 alkoxy, or hydroxyl group; R 15 =H or C 1-10 alkyl; R 16 =C 1-10 hydrocarbyl or phenyl; R 17 =C 1-10 hydrocarbyl or phenyl; R 18 =C 1-10 hydrocarbyl or phenyl.