Patent ID: 7368434

Claim:
A method of reducing alcohol consumption in a mammal comprising administering a compound of Formula I wherein: R 1 is selected from the group consisting of hydrogen, carboxy, halo, branched or straight chain (C 1 -C 6 )haloalkyl, (C 3 -C 6 )cycloalkoxy, (C 1 -C 6 )haloalkoxy, (C 3 -C 6 )cyclohaloalkoxy, (C 3 -C 6 )cycloalkoxyalkyl, (C 1 -C 6 )alkoxy(C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkylcarbonyl, substituted or unsubstituted phenyl, phenyl(C 1 -C 6 )alkyl, and heterocyclyloxy, heterocyclylcarbonyl, wherein substituents are from one to four and are selected from the group consisting of halo, aminocarbonyl, aminothiocarbonyl, carboxy, formyl, hydroxy, amino, carbamoyl, (C 1 -C 3 )alkyl, (C 1 -C 3 )haloalkyl, (C 1 -C 3 )alkoxy, (C 1 -C 3 )haloalkoxy, (C 1 -C 3 )alkylamino, di(C 1 -C 3 )alkylamino, (C 1 -C 2 )alkoxy(C 1 -C 2 )alkyl, (C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, (C 1 -C 3 )alkylcarbonyl, (C 1 -C 3 )alkoxycarbonyl, (C 1 -C 3 )alkylaminocarbonyl, and di(C 1 -C 3 )alkylaminocarbonyl; R 2 is selected from the group consisting of hydrogen and alkoxy; R 3 is selected from the group consisting of hydrogen, (C 1 -C 6 ) alkoxycarbonyl, and carboxy; R 4 is selected from the group consisting of hydrogen and hydroxy; R 5 is selected from the group consisting of hydrogen, carboxy, hydroxy, amino, halo, branched or straight chain (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 2 -C 6 )alkenyl, (C 3 -C 6 )alkadienyl, (C 1 -C 6 )alkoxy, (C 3 -C 6 )cycloalkoxy, (C 1 -C 6 )haloalkoxy, (C 3 -C 6 )cyclohaloalkoxy, (C 2 -C 6 )alkynyloxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkoxyalkyl, C 1 -C 6 )alkoxy(C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkylcarbonyl, (C 3 -C 6 )cycloalkylcarbonyl, (C 1 -C 6 )alkoxycarbonyl, (C 4 -C 6 )alkoxycarbonylalkyl, (C 1 -C 6 )hydroxyalkyl, substituted or unsubstituted phenyl, phenyl(C 1 -C 6 )alkyl, heterocyclyl, heterocyclyloxy, heterocyclylcarbonyl, wherein substituents are from one to four and are selected from the group consisting of halo, aminocarbonyl, aminothiocarbonyl, carboxy, formyl, hydroxy, amino, carbamoyl, (C 1 -C 3 )alkyl, (C 1 -C 3 )haloalkyl, (C 1 -C 3 )alkoxy, (C 1 -C 3 )haloalkoxy, (C 1 -C 3 )alkylamino, di(C 1 -C 3 )alkylamino, (C 1 -C 2 )alkoxy(C 1 -C 2 )alkyl, (C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, (C 1 -C 3 )alkylcarbonyl, (C 1 -C 3 )alkoxycarbonyl, (C 1 -C 3 )alkylaminocarbonyl, and di(C 1 -C 3 )alkylaminocarbonyl; R 6 is selected from the group consisting of hydrogen and hydroxy; and R 7 is selected from the group consisting of hydrogen and halogen, with the proviso that R 5 cannot be hydroxy when R 1 , R 2 , R 3 , R 4 , R 6 , and R 7 are all hydrogen in an amount effective to increase a concentration of 5-hydroxyindoleacetaldehyde formed during catabolism of serotonin or dopamine.