Patent ID: 8183254

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: each of R 1 and R 2 is independently H or lower alkyl; or R 1 and R 2 together form a cycloalkyl ring, optionally substituted with one or more R 2′ ; R 2′ is lower alkyl, hydroxy, halogen, amino, lower alkoxy, lower hydroxyalkyl, or lower haloalkyl; R 3 is H or N(R 4 )(R 5 ); R 4 is H, lower alkyl, or C(═O)OR 4′ ; R 4′ is H or lower alkyl; R 5 is H or lower alkyl; or R 2 and R 3 together form a heterocyclic or heteroaryl ring, optionally substituted with one or more R 2′ ; Q is CH or N; Z 1 is (CH 2 ) u ; u is 0 or 1; Z 2 is (CH 2 ) v ; v is 0 or 1; X 1 is lower alkyl, lower alkoxy, lower haloalkyl, or hydroxy; m is 0, 1, or 2; X 2 is lower alkyl, lower alkoxy, or lower haloalkyl; n is 0 or 1; X 3 is lower alkyl, lower alkoxy, or lower haloalkyl; p is 0 or 1; X 4 is lower alkyl, lower alkoxy, lower haloalkyl, hydroxy, lower hydroxylalkyl, or halogen; q is 0, 1, or 2; X 5 is lower alkyl, lower alkoxy, lower haloalkyl, hydroxy, lower hydroxylalkyl, or halogen; r is 0, 1, or 2; Y 1 is CH(Y 1′ ); Y 1′ is H or lower alkyl; Y 2 is H or Y 2′ ; Y 2′ is lower alkyl, N(Y 2″ ) 2 , lower haloalkyl, or lower heteroalkyl; or Y 1′ and Y 2′ together form a heterocyclic ring; and each Y 2″ is independently H, lower alkyl, lower cycloalkyl, phenyl, or lower heterocycloalkyl; or both Y 2″ together form a heterocyclic ring.