Patent ID: 8796253

Claim:
A compound having the formula: or a physiologically acceptable salt thereof, wherein: A is heteroaryl optionally substituted with halogen or phenyl, or is heterocyclyl; n is an integer from 0-3; R 1 at each occurrence is independently halogen, —NR 6 C(O)R 7 , —C(O)R 6 , —C(O)OR 6 , —OC(O)R 6 , —OR 6 , —SR 6 , —S(O)R 6 , —SO 2 R 6 , cyano, nitro, —C(O)NR 6 R 7 , —SO 2 NR 6 R 7 , or —NR 6 R 7 , or R 1 is independently aryl, heteroaryl, heterocyclyl, alkyl or cycloalkyl each optionally substituted with one or more halogen, OR 6 or NR 6 R 7 groups; R 2 is aryl optionally substituted with 1, 2 or 3 R 8 groups or heteroaryl optionally substituted with 1, 2 or 3 R 8 groups, when A is mono- or bicyclic heteroaryl or mono- or bicyclic heterocyclyl, or R 2 is hydrogen, halogen, cyano, alkyl optionally substituted with up to 3 fluoro atoms, alkyloxy optionally substituted with up to 3 fluoro atoms, cycloalkyl, aryloxy, aroyl, aralkyl optionally substituted with halogen, or heterocyclyl optionally substituted with alkyl, when A is bi- or tricyclic heteroaryl or mono-, bi- or tricyclic heterocyclyl; R 3 and R 4 are each independently hydrogen, halogen, —OR 6 , —SR 6 , —NR 6 R 7 , alkyl optionally substituted with one or more halogen, R 6 , —OR 6 or —NR 6 R 7 groups, or cycloalkyl optionally substituted with one or more halogen, R 6 , —OR 6 or —NR 6 R 7 groups; R 5 is hydrogen, oxo, or alkyl optionally substituted with one or more halogen, —OR 6 or —NR 6 R 7 groups; each occurrence of R 6 or R 7 may be the same or different and is independently hydrogen, or aryl, heteroaryl, heterocyclyl, alkyl, or cycloalkyl each of which may be optionally substituted with one or more hydrogen, halogen, —OR 9 or —NR 9 R 10 groups; each occurrence of R 8 may be the same or different and is independently hydrogen, halogen, —NR 9 C(O)R 10 , —NR 9 C(O)OR 10 , —C(O)R 9 , —C(O)OR 9 , —OC(O)R 9 , —OR 9 , —SR 9 , —S(O)R 9 , —SO 2 R 9 , cyano, nitro, —C(O)NR 9 R 10 , —SO 2 NR 9 R 10 , —NR 9 R 10 , or aryl, heteroaryl, heterocyclyl, alkyl, or cycloalkyl, each of which may be optionally substituted with one or more halogen, R 11 , —OR 9 or —NR 9 R 10 groups; each occurrence of R 9 and R 10 may be the same or different and is independently hydrogen, or aryl, heteroaryl, heterocyclyl, alkyl, cycloalkyl, aralkyl, or heterocyclylalkyl each of which may be optionally substituted with one or more hydrogen, halogen, hydroxyl, alkyloxy, cycloalkyloxy, aryloxy, amino, alkylamino, cycloalkylamino, arylamino, alkyl, cycloalkyl, alkylcarbonyl or alkoxycarbonyl groups; each occurrence of R 11 may be the same or different and is independently hydrogen, oxo, aryl, heteroaryl, heterocyclyl, alkyl, cycloalkyl, —C(O)R 9 , —C(O)OR 9 , —NR 12 C(O)R 13 , —N[C(O)R 13 ] 2 , —NR 12 C(O)OR 13 , or —N[C(O)OR 13 ] 2 ; R 12 is hydrogen or alkyl; and R 13 is alkyl.