Patent ID: 8883832

Claim:
A method for treating a subject with cancer, comprising administering to the subject and effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl unit having the formula: R 2 , R 3 , and R 4 are each independently: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted C 2 -C 6 linear, branched, or cyclic alkenyl; iv) substituted or unsubstituted C 2 -C 6 linear or branched alkynyl; v) substituted or unsubstituted C 6 or C 10 aryl; vi) substituted or unsubstituted C 1 -C 9 heteroaryl; vii) substituted or unsubstituted C 1 -C 9 heterocyclic; or viii) R 2 and R 3 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms; wherein from 1 to 3 atoms can optionally be heteroatoms chosen from oxygen, nitrogen, and sulfur; Z is a unit having the formula: -(L) n -R 1 R 1 is chosen from: i) hydrogen; ii) hydroxyl; iii) amino; iv) substituted or unsubstituted C 1 -C 6 linear, branched or cyclic alkyl; v) substituted or unsubstituted C 1 -C 6 linear, branched or cyclic alkoxy; vi) substituted or unsubstituted C 6 or C 10 aryl; vii) substituted or unsubstituted C 1 -C 9 heterocyclic rings; or viii) substituted or unsubstituted C 1 -C 9 heteroaryl rings; L is a linking unit having the formula: -[Q] y [C(R 5a R 5b )] x [Q 1 ] z [C(R 6a R 6b )] w — Q and Q 1 are each independently: i) —C(O)—; ii) —NH—; iii) —C(O)NH—; iv) —NHC(O)—; v) —NHC(O)NH—; vi) —NHC(O)O—; vii) —C(O)O—; viii) —C(O)NHC(O)—; ix) —O—; x) —S—; xi) —SO 2 —; xii) —C(═NH)—; xiii) —C(═NH)NH—; xiv) —NHC(═NH)—; or xv) —NHC(═NH)NH—; R 5a and R 5b are each independently: i) hydrogen; ii) hydroxy; iii) halogen; iv) C 1 -C 6 substituted or unsubstituted linear or branched alkyl; or v) a unit having the formula: —[C(R 7a R 7b )] t R 8 R 7a and R 7b are each independently: i) hydrogen; or ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; R 8 is: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted C 6 or C 10 aryl; iv) substituted or unsubstituted C 1 -C 9 heteroaryl; or v) substituted or unsubstituted C 1 -C 9 heterocyclic; R 6a and R 6b are each independently: i) hydrogen; or ii) C 1 -C 4 linear or branched alkyl; the index n is 0 or 1; the indices t, w and x are each independently from 0 to 4; the indices y and z are each independently 0 or 1; or a pharmaceutically acceptable salt thereof.