Patent ID: 8350043

Claim:
A compound of formula: or a pharmaceutically acceptable salt thereof, wherein X 4 -X 5 is chosen from CR 4 —CR 5 ; one of X 6 , X 7 and X 8 is N and the other two are CR 4 and CR 5 ; R 1 is chosen from (C 1-10 )alkyl, (C 3-10 )cycloalkyl, and [(C 3-10 )cycloalkyl(C 1-2 )alkyl], said (C 1-10 )alkyl, (C 3-10 )cycloalkyl, and [(C 3-10 )cycloalkyl(C 1-2 )alkyl] being optionally substituted with one or more halogens, (C 1-6 )alkoxy, (C 2-6 )alkenyl, (C 2-6 )alkynyl, phenyl or benzyl; Ar is chosen from (i) (C 6-10 )aryl, optionally substituted within 1-3 substituents selected from halogen, hydroxy, cyano, COOR 5 , phenyl, (C 5-6 )heteroaryl, (C 1-6 )alkyl, (C 3-6 )cycloalkyl, (C 1-6 )alkyloxy and (C 3-6 )cycloalkyloxy, said (C 1-6 )alkyl, (C 3-6 )cycloalkyl, (C 1-6 )alkyloxy and (C 3-6 )cycloalkyloxy being optionally substituted with one or more halogens; (ii) (C 5-10 )heteroaryl optionally substituted with a substituent selected from methyl, (C 1-6 )alkyloxy or halogen; and (iii) (C 4-7 )cycloalkyl; R 4 and R 5 are independently chosen from H, (C 1-6 )alkyl, (C 1-6 )alkyloxy or halogen, said (C 1-6 )alkyl, (C 1-6 )alkyloxy being optionally substituted with one or more halogens; G is a linking moiety spanning 4 to 7 atoms between termini; and R 8 and R 9 are hydrogen or alkyl, or NR 8 R 9 is a saturated nitrogenous heterocycle of 3-10 carbons in one or two rings.