Patent ID: 8318429

Claim:
A method of identifying a human subject's risk of developing schizophrenia, the method comprising: determining a SH3 and multiple ankyrin repeat domains 3 gene (SHANK3) haplotype of the subject, wherein the SHANK3 haplotype comprises alleles of single nucleotide polymorphism rs9616816 and single nucleotide polymorphism rs6010063; and identifying the subject as a human subject having an increased risk of developing schizophrenia when the haplotype comprises an “A” allele at said single nucleotide polymorphism rs9616816 and an “A” allele at said single nucleotide polymorphism rs6010063, or identifying the subject as a human subject having a decreased risk of developing schizophrenia when the haplotype comprises a “G” allele at said single nucleotide polymorphism rs9616816 and a “G” allele at said single nucleotide polymorphism rs6010063.