Patent ID: 7273877

Claim:
A compound of Formula I wherein W is Q is —O—(CH 2 ) k CH 3 , —NH 2 , —NH[(CH 2 ) k CH 3 ], or —NH[O(CH 2 ) k CH 3 ], wherein the —NH 2 is optionally substituted with between 1 and 2 substituents independently selected from methyl and amino, and the —(CH 2 ) k CH 3 moieties of the —O—(CH 2 ) k CH 3 , —NH[(CH 2 ) k CH 3 ], and —NH[O(CH 2 ) k CH 3 ] groups are optionally substituted with between 1 and 3 substituents independently selected from hydroxy, amino, alkyl and cycloalkyl; Z is —NH 2 , —NH[(CH 2 ) k CH 3 ], or —NH[O(CH 2 ) k CH 3 ], wherein the —NH 2 is optionally substituted with between 1 and 2 substituents independently selected from methyl and amino, and the —(CH 2 ) k CH 3 moieties of the —NH[(CH 2 ) k CH 3 ], and —NH[O(CH 2 ) k CH 3 ] groups are optionally substituted with between 1 and 3 substituents independently selected from hydroxy and amino; R 1 is hydrogen, C 1-6 alkyl, C 2-4 alkenyl or —(CH 2 ) k O(CH 2 ) k OCH 3 , wherein the C 1-6 alkyl is optionally substituted with between 1 and 2 substituents independently selected from hydroxy, —COOH, and cyano; R 2 is hydrogen, chlorine, fluorine or methyl; R 3 is hydrogen, chlorine, fluorine, methyl, or CF 3 ; R 4 is bromine, chlorine, fluorine, iodine, C 1-6 alkyl, C 2-4 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, —(CH 2 )—C 3-6 cycloalkyl, cyano, —O—(C 1-4 alkyl), —S—(C 1-2 alkyl), —SOCH 3 , —SO 2 CH 3 , —SO 2 NR 6 R 7 , —C≡C—(CH 2 ) n NH 2 , —C≡C—(CH 2 ) n NHCH 3 , —C≡C—(CH 2 ) n N(CH 3 ) 2 , —C≡C—CH 2 OCH 3 , —C═C(CH 2 ) n OH, —C═C—(CH 2 ) n NH 2 , —CHCHCH 2 OCH 3 , —CHCH—(CH 2 ) n NHCH 3 , —CHCH—(CH 2 ) n N(CH 3 ) 2 , —(CH 2 ) p CO 2 R 6 , C(O)C 1-3 alkyl, C(O)NHCH 3 , —(CH 2 ) m NH 2 , —(CH 2 ) m NHCH 3 , —(CH 2 ) m N(CH 3 ) 2 , —(CH 2 ) m OR 8 , —CH 2 S(CH 2 ) t (CH 3 ), —(CH 2 ) p CF 3 , —C≡CCF 3 , —CH═CHCF 3 , —CH 2 CHCF 2 , —CH═CF 2 , —(CF 2 ) v CF 3 , —CH 2 (CF 2 ) n CF 3 , —(CH 2 ) t CF(CF 3 ) 2 , —CH(CF 3 ) 2 , —CF 2 CF(CF 3 ) 2 , or —C(CF 3 ) 3 , wherein the C 1-6 alkyl and C 2-6 alkynyl are optionally substituted with between 1 and 3 substituents independently selected from hydroxy and alkyl; or R 3 and R 4 can be joined together to form a six-membered aryl ring, five-membered cycloalkyl ring or a five or six-membered heteroaryl ring; R 5 is hydrogen, chlorine, fluorine, or methyl; R 6 and R 7 are each independently hydrogen, methyl, or ethyl; k is 0 to 3; m is 1 to 4; n is 1 to 2; p is 0 to 2; t is 0 to 1; v is 1 to 5; or pharmaceutically acceptable salts, C 1-6 amides or C 1-6 esters thereof.