Patent ID: 8623368

Claim:
A human recombinant monoclonal antibody, which specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, wherein the human recombinant monoclonal antibody comprises: (a) a heavy chain variable region that contains heavy chain CDR1 as defined by SEQ ID NO.2; heavy chain CDR2 as defined by SEQ ID NO.3; and heavy chain CDR3 as defined by SEQ ID NO.4, and a light chain variable region that contains light chain CDR1 as defined by SEQ ID NO. 6; light chain CDR2 as defined by SEQ ID NO.7; and light chain CDR3 as defined by SEQ ID NO.8; or (b) a heavy chain variable region that contains heavy chain CDR1 as defined by SEQ ID NO. 10; heavy chain CDR2 as defined by SEQ ID NO. 11; and heavy chain CDR3 as defined by SEQ ID NO. 12, and a light chain variable region that contains light chain CDR1 as defined by SEQ ID NO. 14; light chain CDR2 as defined by SEQ ID NO. 15; and light chain CDR3 as defined by SEQ ID NO. 16.