Patent ID: 7476517

Claim:
A method to selectively incorporate or encapsulate a proteinaceous target molecule complex, comprising a target molecule and one or more complexing components, into a virus like particle comprising the steps of: expressing in cells a) a target molecule, said target molecule comprising a coiled-coil sequence fused to a G-protein coupled receptor, and b) a complexing component comprising a G-protein, and c) a signal molecule comprising a coiled-coil sequence fused to a retroviral capsid sequence, wherein said retroviral capsid sequence confers on the signal molecule the ability to assemble into virus like particles, incorporating or encapsulating a target molecule complex into virus like particles through the interaction of said coiled-coil sequence of said target molecule with said coiled-coil sequence of said signal molecule, wherein said coiled-coil interaction is between a K-coil and an E-coil, and wherein said target molecule complex is an association between said target molecule and said complexing component.