Patent ID: 8652423

Claim:
A vial and closure assembly, comprising: a vial having an open end defined by a vial rim and at least one outer thread located proximate the open end of the vial; and a closure configured to be received by the open end of the vial and comprising: a top wall; a skirt wall having an inner surface and depending from the top wall; an inner thread provided on the inner surface of the skirt wall; an opening formed through the top wall; a septum pocket provided in the top wall and configured to receive a septum positioned within the septum pocket; and a protrusion depending from the top wall and extending into the septum pocket, the protrusion having an inner surface and an outer surface that are asymmetric relative to a vertical plane extending through a peak of the protrusion, wherein, when the closure is threadably coupled to the vial, the protrusion is configured to engage the septum so that the septum creates an essentially vapor-tight seal with the vial rim.