Patent ID: 7189864

Claim:
A method of preparing an aminoepoxide compound of Formula I: wherein P 1 and P 2 independently are selected from acyl, aralkyl, alkenyl, silyl, aralkylcarbonyl, alkoxycarbonyl and cycloalkenylalkyl; wherein further P 1 and P 2 may be taken together with the nitrogen atom of Formula I to form a heterocyclic ring system containing said nitrogen atom as a ring member; and wherein P 1 or P 2 may be substituted at one or more substitutable positions with one or more radicals independently selected from halo, alkyl of C 1 –C 8 , alkoxy, hydroxy, nitro, alkenyl, amino, alkylamino, acylamino and acyl; or a pharmaceutically-acceptable salt thereof; said method comprising the steps of forming a protected aminoalcohol, oxidizing said protected aminoalcohol to a chiral protected aminoaldehyde and diastereoselectively forming the aminoepoxide from said aminoaldehyde with an organometallic methylene-adding reagent in an appropriate solvent.