Patent ID: 7196088

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, wherein: n is from 0 to 3; X is —CR a R b — wherein R a and R b each independently are hydrogen or alkyl; ---- is an optional bond; Y is —SO 2 —; each R 1 independently is halo, alkyl, haloalkyl, hydroxy, nitro, alkoxy, cyano, —S(O) q —R e , —NR c R f , or —C(═O)—NR c R f , wherein q is from 0 to 2 and R e and R f each independently are hydrogen or alkyl; R 2 is phenyl or naphthyl optionally substituted with halo, alkoxy, haloalkyl, alkyl, or —C(O)—NH 2 ; R 3 and R 4 each independently are hydrogen or alkyl; and R 5 is at the 5- or 6-position of the isoquinoline ring system and is of the formula: wherein: Z is —N—; r is 2; and R 6 , R 7 , R 8 , R 9 and R 10 each independently are hydrogen or alkyl.