Patent ID: 7595199

Claim:
A method of detecting the presence of detergent- or urea-insoluble amyloid-like fibrils or protein aggregates in a sample on a filter comprising the following steps: (a) treating a sample suspected of comprising amyloid-like fibrils or protein aggregates by adding detergent or urea to solubilize the sample; (b) contacting a cellulose acetate or nitrocellulose filter having a pore size capable of retaining detergent- or urea-insoluble amyloid-like fibrils or protein aggregates with the sample and filtering said sample through the filter to capture said detergent or urea insoluble amyloid-like fibrils or protein aggregates; and (c) detecting said amyloid-like fibrils or protein aggregates that are retained on said filter.