Patent ID: 8617602

Claim:
A multi-layer solid oral pharmaceutical composition comprising; (i) a first distinct layer comprising: (a) a first pharmaceutically active agent bound to a weak acid ion exchange resin to form a weak acid ion-exchange resinate; and (b) a release-enhancing agent consisting of FeCl 3 ; (ii.) at least a second distinct layer comprising: (a) a drug selected from the group consisting of said first pharmaceutically active agent and a second pharmaceutically active agent, said drug being bound to a strong acid ion exchange resin to form a strong acid ion-exchange resinate; and (b) optionally, a coating to slow and extend release of the drug contained therein; wherein said pharmaceutical composition is capable of immediate release of said first pharmaceutically active agent from said weak acid resinate at a pH of at least 1.5, immediate release being defined as at least 80% release of said pharmaceutically active agent within 45 minutes in a standard dissolution apparatus according to USP 34 NF 26 section 711; and, wherein release of the drug from said strong acid resinate continues over a period of at least 8 hours after ingestion.