Patent ID: 6965030

Claim:
A compound of Formula I: or a phamaceutically acccptable salt, hydrate or prodrug thoroof, wherein: Z is CH; X 1 is O, NR 4 (where R 4 is hydrogen or alkyl), S or C═O; R 1 is alkyl, cycloalkyl, cycloalkylalkyl or—CH 2 -alkenyl; R 2 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, araldkyl, haloalkyl, heteroalkyl, cyanoakyl, alkylene-C(O) R 21 (where R 21 is hydrogcn, alky, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), amino, monoalkylamino, dialkylarmino, acyl, or NR 22 —Y—R 23 (where Y is —C(O), —C(O)O—, —C(O)NR 24 , S(O) 2 or S(O) 2 NR 25 ; R 22 , R 24 and R 25 are independently hydrogen or alkyl; and R 23 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or optionally-substituted phenyl); and R 3 is alkyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstiuted cycloalkyl, heteroalkyl, cyancoalkyl, heterocycly, heterocyclalkyl, or -heterocycloamino-SO 2 —R 12 (where R 12 is haloalkyl, aryl, aryalkyl, heteroaryl or heteroaralkyl).