Patent ID: 7320972

Claim:
A compound of formula: wherein represents an aryl or heteroaryl residue; Ar represents an aryl residue; R 1 represents one, two, three, four or five residues chosen independently from H, halogen, —OH, loweralkyl, OCF 2 H, OCF 3 , CF 2 H, CH 2 F, —O-loweralkyl, methylenedioxy, ethylenedioxy, hydroxyloweralkyl, —CN, CF 3 , nitro, —SH, —S-loweralkyl, amino, alkylamino, dialkylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, arylsulfonyl, acyl, carboxy, alkoxycarbonyl, carboxyalkyl, carboxamido, alkylsulfoxide, acylamino, amidino, phenyl, benzyl, phenoxy, benzyloxy, —PO 3 H 2 , —SO 3 H, and —B(OH) 2 , R 2 represents one, two, three, four or five residues chosen independently from H, halogen, —OH, loweralkyl, OCF 2 H, OCF 3 , CF 2 H, CH 2 F, —O-loweralkyl, methylenedioxy, ethylenedioxy, hydroxyloweralkyl, —CN, CF 3 , nitro, —SH, —S-loweralkyl, amino, alkylamino, dialkylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, arylsulfonyl, acyl, carboxy, alkoxycarbonyl, carboxyalkyl, carboxamido, alkylsulfoxide, acylamino, amidino, —PO 3 H 2 , —SO 3 H, and —B(OH) 2 ,; R 4 represents one, two, three or four residues chosen independently from H, halogen, —OH, loweralkyl, —O-loweralkyl, hydroxyloweralkyl, —CN, CF 3 , nitro, —SH, —S-loweralkyl, amino, alkylamino, dialkylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, arylsulfonyl, acyl, carboxy, alkoxycarbonyl, carboxyalkyl, carboxamido, alkylsulfoxide, acylamino, amidino, —PO 3 H 2 , —SO 3 H, and —B(OH) 2 , R 5g represents one, two, three, four or five residues on Ar chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, methylenedioxy, ethylenedioxy, hydroxyloweralkyl, —CN, CF 3 , nitro, —SH, —S-loweralkyl, amino, alkylamino, dialkylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, arylsulfonyl, acyl, carboxy, alkoxycarbonyl, carboxyalkyl, carboxamido, alkylsulfoxide, acylamino, amidino, —PO 3 H 2 , —SO 3 H, and —B(OH) 2 ; U is (C 2 -C 6 )-alkylene in which one or more individual —CH 2 — may be replaced by a radical chosen from —S—, —S(O)—, —SO 2 —, —O—, —C(═O)—, —CHOH—, —NH—, CHF, CF 2 , —CH(O-loweralkyl)-, —CH(O-loweracyl)-, —CH(OSO 3 H)—, —CH(OPO 3 H 2 )—, —CH(OB(OH) 2 )—, or —NOH—; with the provisos that R 5g cannot be —CN; 2,5-dimethoxy; 2,6-dimethoxy or halogen when neither of R 4 and R 5g includes an —OH, amino, loweralkyl, O-loweralkyl, alkoxycarbonyl, —B(OH) 2 , —PO 3 H 2 or —SO 3 H group; R 5g cannot be 2-hydroxy when represents a 2,5-thienyl residue; adjacent —CH 2 — residues in U cannot be replaced by —S—, —S(O)—, —SO 2 — or —O—; and —S—, —S(O)—, —SO 2 —, —O— and —NH— residues in U cannot be separated only by a single carbon.