Patent ID: 7148250

Claim:
A compound of formula I or a pharmaceutically acceptable salts, hydrates or optical isomers of said compound, wherein: A 1 , A 2 , A 3 and A 4 are independently hydrogen, C 1 –C 9 alkyl, C 2 –C 9 alkenyl, C 2 –C 9 alkynyl, aryl, heteroaryl, carbocycle, heterocycle, C 1 –C 9 alkoxy, C 2 –C 9 alkenyloxy, phenoxy, benzyloxy, hydroxy, halo, nitro, cyano, isocyano, —COOR 6 , —COR 6 , —NR 6 R 7 , —SR 6 , —SOR 6 , —SO 2 R 6 , —SO 2 (OR 6 ), —(C═O)NR 6 R 7 , —(C═O)NR 6 (CH 2 ) n COOH, —NR 6 (C═O)R 7 or —(CH 2 ) n COOH, or any adjacent two of A 1 , A 2 , A 3 and A 4 form with the benzene ring a fused ring that is saturated or unsaturated, aromatic or non-aromatic, and carbocyclic or heterocyclic, said heterocyclic ring containing 1 or 2 oxygen, nitrogen and/or sulfur heteroatom(s); n is 1–3; R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are independently hydrogen, carboxy, C 1 –C 9 alkyl, C 2 –C 9 alkenyl, C 2 –C 9 alkynyl, aryl, heteroaryl, carbocycle or heterocycle; and said alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocycle, heterocycle, alkoxy, alkenyloxy, phenoxy, benzyloxy and fused ring are independently unsubstituted or substituted with one or more substituent(s).