Patent ID: 7442501

Claim:
A method of identifying a compound that modulates a glycosaminoglycan biosynthetic biological activity, said method comprising the steps of: (a) providing a first cell comprising a wild-type sqv nucleic acid molecule; (b) providing a second cell comprising a sqv-1, sqv-2, sqv-4, sqv-5, or sqv-6 mutant nucleic acid molecule; (c) contacting said first cell with a candidate compound; (d) contacting said second cell with said candidate compound; and (e) detecting, in a protein extract from said first or second cell, an alteration of an enzymatic activity that contributes to the production of a glycosaminoglycan in said first cell when compared to said second cell, wherein said alteration identifies said compound as modulating a glycosaminoglycan biosynthetic biological activity.