Patent ID: 6984383

Claim:
A method for transplanting cells to a patient in need thereof, comprising: a) obtaining cells from a donor, b) obtaining recipient cells from the patient; c) contacting the donor cells with an immunoglobulin specific to B7-1 and an immunoglobulin specific to B7-2, wherein the immunoglobulin specific to B7-2 has a binding affinity of at least about 10 7 M −1 , and wherein said immunoglobulin comprises an antigen binding region of non-human origin and at least a portion of an immunoglobulin of human origin, further wherein the antigen binding region of non-human origin comprises at least one framework region containing a substitution of at least one amino acid to a corresponding amino acid in the III2R heavy chain framework region or the H2F light chain framework region; d) combining b) and c) to form a mixture, and e) introducing the mixture of step d) to the patient.