Patent ID: 8114894

Claim:
A compound of formula II: or pharmaceutically acceptable salts or N-oxides thereof, wherein R 1 is, independently for each occurrence, selected from halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, nitro, cyano, amino, sulfonyl, C 1 -C 6 alkylsulfonyl, sulfamoyl, carbamoyl, carboxyl, N—C 1 -C 6 alkylsulfamoyl, and N—C 1 -C 6 alkylcarbamoyl; B is selected from formulae IIA and IIB: R 2 is selected from C 1 -C 6 alkyl and C 3 -C 6 cycloalkyl, wherein R 2 may be optionally substituted with one, two, or three substituents selected, independently for each occurrence, from halogen, alkoxy, nitro, cyano, amino, and carboxyl; R 3 and R 4 are each independently selected from hydrogen, C 1 -C 6 alkoxy, C 1 -C 6 alkyl, aryl, C 3 -C 6 cycloalkyl, halogen, heteroaryl, heterocyclyl, and hydroxyl, wherein R 3 or R 4 , if not hydrogen, may be optionally substituted by one, two, or three substituents represented by R 10 , or R 3 and R 4 are taken together with the carbon atom to which they are attached to form a four, five, or six membered heterocyclyl or C 3 -C 6 cycloalkyl optionally substituted by one, two, or three substituents each represented by R 10 ; R 7 is selected from C 1 -C 6 alkoxy, C 1 -C 6 alkyl, cyano, halogen, hydrogen, and hydroxyl; R 8 is selected from hydrogen and alkyl optionally substituted by one, two, or three substituents each selected from halogen, hydroxyl, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkoxy, N—C 1 -C 6 alkylamino, N,N-diC 1 -C 6 alkylamino, cyano, carboxyl, sulfonamido, and C 1 -C 6 alkylsulfonamido; R 9 is, independently for each occurrence, selected from hydrogen, halogen, hydroxyl, nitro, cyano, amino, sulfonyl, C 1 -C 6 alkylsulfonyl, sulfamoyl, sulfonamido, C 1 -C 6 alkylsulfonamido, carbamoyl, carboxyl, N—C 1 -C 6 alkylsulfamoyl, and N—C 1 -C 6 alkylcarbamoyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkylthio, and C 1 -C 6 alkoxy, wherein the alkyl, cycloalkyl or alkoxy is optionally substituted by one, two, or three substituents independently selected from halogen, hydroxyl, carboxy, cyano, amido, nitro, and amino; R 10 is, independently for each occurrence, selected from halogen, hydroxyl, nitro, cyano, amino, sulfonyl, C 1 -C 6 alkylsulfonyl, sulfamoyl, sulfonamido, C 1 -C 6 alkylsulfonamido, carbamoyl, carboxyl, N—C 1 -C 6 alkylsulfamoyl, and N—C 1 -C 6 alkylcarbamoyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkylthio, and C 1 -C 6 alkoxy, wherein the alkyl, cycloalkyl or alkoxy is optionally substituted by one, two, or three substituents independently selected from halogen, hydroxyl, carboxy, cyano, amido, nitro, and amino; and m is 0, 1, 2, 3, or 4.