Patent ID: 8637542

Claim:
A compound of Formula I or its pharmaceutically acceptable salt thereof, wherein: M 1 is wherein: W 4 is N—R 5 , O, or S, W 6 is N or C—R 5 ; W 10 is N—R 5 , O, or S; W 8 is N or C—R 5 ; each R 5 is independently —(W 1 ) k —R 53 or R 55 ; R 1 and R 2 are independently H, -L-alkyl, -L-cycloalkyl, L-alkylcycloalkyl, -L-aryl, -L-heteroaryl, L-alkylaryl, -L-alkylheteroaryl, -L-alkylheterocyclyl, -L-alkenyl, -L-alkynyl, L-_alkenylcycloalkyl, -L-alkynylcycloalkyl, -L-heterocyclyl, wherein each alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkenyl, or alkynyl moiety is unsubstituted or is substituted by one or more independent R 3 substituents; L is absent, —C(O)—, —C(O)O—, —C(O)NR 31 —, —S—, —S(O)—, —S(O) 2 —, —S(O) 2 NR 31 —, N(R 31 )C(O)— or —NR 31 ; X 1 is independently C-E 1 ; X 2 is NH, X 3 is C, and X 4 is C; or X 2 is N, X 3 is C, and X 4 is N; or X 2 is N, X 3 is N, and X 4 is N; or X 2 is N, X 3 is N, and X 4 is C; or X 2 is C-E 1 , X 3 is N, and X 4 is C; or X 2 is C-E 1 , X 3 is C, and X 4 is N; E 1 is —(W 1 ) j —R 4 ; j, in each instance, is independently 0 or 1; W 1 is —O—, —NR 6 —, —S(O) 0-2 —, —C(O)—, —C(O)N(R 6 )—, —N(R 6 )C(O)—, —N(R 6 )S(O)—, —N(R 6 )S(O) 2 —, —C(O)O—, —CH(R 6 )N(C(O)OR 7 )—, —CH(R 7 )N(C(O)R 7 )—, —CH(R 6 )N(SO 2 R 7 )—, —CH(R 6 )N(R 7 )—, —CH(R 6 )C(O)N(R 7 )—, —CH(R 6 )N(R 7 )C(O)—, —CH(R 6 )N(R 7 )S(O)—, or —CH(R 6 )N(R 7 )S(O) 2 —; R 3 and R 4 are independently hydrogen, halogen, aryl, heteroaryl, alkyl, cycloalkyl, alkyl-cycloalkyl, alkenyl, alkynyl, alkoxy, or heterocyclyl; R 6 and R 7 are each independently hydrogen, alkyl, alkenyl, aryl, heteroaryl, heterocyclyl or cycloalkyl, wherein each alkyl, alkenyl, aryl, heteroaryl, heterocyclyl or cycloalkyl is unsubstituted or substituted by one or more independent R 8 substituents; and R 8 is halo, —OR 31 , —SH, NH 2 , —NR 34 R 35 , —NR 31 R 32 , —CO 2 R 31 , —CO 2 aryl —CO 2 NR 31 R 32 , C(═O)NR 34 R 35 , —NO 2 , —CN, —S(O) 0-2 alkyl, —S(O) 0-2 aryl, —SO 2 NR 34 R 35 , —SO 2 NR 31 R 32 , alkyl, alkenyl, or alkynyl; R 31 , R 32 , and R 33 , in each instance, are independently H or alkyl; R 34 and R 35 are taken together with the nitrogen atom to which they are attached to form a 3-10 membered ring R 53 is hydrogen, aryl, hetaryl, alkyl, cycloalkyl, alkyl-cycloalkyl, alkenyl, alkynyl, alkoxy, or heterocyclyl; and R 55 is halo, —OH, —R 31 , —CF 3 , —O-aryl, —OCF 3 , —OR 31 , —NR 31 R 32 , —NR 34 R 35 , —C(O)R 31 , —CO 2 R 31 , —C(═O)NR 31 R 32 , —NO 2 , —CN, —S(O) 0-2 R 31 , —SO 2 NR 31 R 32 , —SO 2 NR 34 R 35 , —NR 31 C(═O)R 32 , —NR 31 C(═O)OR 32 , —NR 31 C(═O)NR 32 R 33 , —NR 31 S(O) 0-2 R 32 , —C(═S)OR 31 , —C(═O)SR 31 , —NR 31 C(═NR 32 )NR 33 R 32 , —NR 31 C(═NR 32 )OR 33 , —NR 31 (═NR 32 )SR 33 , —OC(═O)OR 33 , —OC(═O)NR 31 R 32 , —C(═O)NNR 34 R 35 , —OC(═O)SR 31 , —SC(═O)OR 31 , —P(O)OR 31 OR 32 , or —SC(═O)NR 31 R 32 .