Patent ID: 8497295

Claim:
A compound of formula (I) or pharmaceutically acceptable salts thereof, wherein Each of R 1 , R 2 , R 3 is independently Q 1 or Q 2 , or R 2 and R 3 together form oxo; Z 1 is —C(Q 1 ) 2 -, —C(H)(Q1)-, —C(H)(Q 5 )-, or —C(O)—; Z 2 is N; L is a bond or —CH 2 —; G is an adamantyl, or a bicyclic or a tricyclic group of the formula (III) in which the adamantyl, and the bicyclic or tricyclic group are connected to L via any ring atom including those in X 1 and ring B, and the bicyclic, and the tricyclic groups are optionally substituted with 1-3 of oxo, ═N—OQ 4 , fluorine, Q 2 , or —C(O)—X 2 -aliphatic, in which X 2 is absent, —O—, —NH—, —NQ 2 -, or —S(O) z — and the aliphatic group is optionally substituted with 1-3 substituents independently selected from Q 3 ; Bond r is a single or double bond and when ring B is present, bond r is fused with B; Ring B, when present, is a 5-6 membered cycloaliphatic or a 3-10 membered heterocycloaliphatic ring, and is optionally substituted with 1-3 of oxo, Q 1 , or Q 2 ; X 1 is —(CH 2 ) i —, —O—, —S—, —N(Q 2 )-, or —N(C(O)—X 2 -aliphatic) in which X 2 is absent, —O—, —NH—, —NQ 2 -, or —S(O) z — and the aliphatic group is optionally substituted with 1-3 substituents independently selected from Q 3 ; Each Q 1 is independently halo, —CN, —NO 2 , —OQ 2 , —S(O) z Q 2 , —S(O) z N(Q 2 ) 2 , —N(Q 2 ) 2 , —C(O)OQ 2 , —C(O)-Q 2 , —C(O)N(Q 2 ) 2 , —C(O)N(Q 2 )(OQ 2 ), —N(Q 2 )C(O)-Q 2 , —N(Q 2 )C(O)N(Q 2 ) 2 , —N(Q 2 )C(O)O-Q 2 , —N(Q 2 )S(O) z -Q 2 or aliphatic optionally including 1-3 substituents independently selected from Q 2 or Q 3 ; Each Q 2 is independently H, aliphatic, cycloaliphatic, aryl, arylalkyl, a 3-10 membered heterocyclic, or heteroaryl ring, each optionally including 1-3 substituents independently selected from Q 3 ; Each Q 3 is halo, oxo, —CN, —NO 2 , —CF 3 , —OCF 3 , —OH, —S(O) z Q 4 , —N(Q 4 ) 2 , —COOQ 4 , —C(O)Q 4 , —OQ 4 , or C 1 -C 4 alkyl optionally substituted with halo, oxo, —CN, —NO 2 , —CF 3 , —OCF 3 , —OH, —SH, —S(O) z H, —NH 2 , or —COOH; Each Q 4 is aliphatic, cycloaliphatic, aryl, aralkyl, a 3-10 membered heterocycloaliphatic, heteroaralkyl, or heteroaryl, each optionally including 1-3 substituents selected from halo, oxo, CN, NO 2 , CF 3 , OCF 3 , OH, SH, —S(O) z H, —NH 2 , or COOH; Each Q 5 is a 3-10 membered heterocyclic ring optionally including 1-3 substituents selected from halo, C 1 -C 4 alkyl, oxo, CN, NO 2 , CF 3 , OCF 3 , OH, SH, —S(O) z H, —NH 2 , COOH; Each i is independently 1, 2, or 3; Each m and n are each 2; Each p is 0; Each y is independently 0 or 1; Each z is independently 0, 1, or 2; and Each t is 1 to 4.