Patent ID: 6906243

Claim:
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence set forth in SEQ ID NO: 1 or 3; (b) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 2 or 4; (c) a nucleotide sequence encoding residues 1-265 of the amino acid sequence set forth in SEQ ID NO: 2 or 4; (d) an antisense nucleotide sequence corresponding to the nucleotide sequence of (a), (b) or (c); (e) a nucleotide sequence encoding a fragment or variant of the amino acid sequence set forth in SEQ ID NO: 2 or 4, wherein said fragment or said variant confers a dominant-negative phenotype in a host cell and said variant has at least 95% sequence identity to at least one amino acid sequence selected from the group consisting of the amino acid sequences set forth in SEQ ID NOS: 2 and 4[, and wherein percent sequence identify is obtained using GAP version 10 with a GAP Weight of 50 and a Length Weight of 3]; (f) a nucleotide sequence encoding an amino acid sequence having at least 95% sequence identify to at least one amino acid sequence selected from the group consisting of the amino acid sequences set forth in SEQ ID NOS: 2 and 4, wherein said nucleotide sequence encodes a protein comprising mismatch-repair; and (g) nucleotides 1-797 of SEQ ID NO: 1.