Patent ID: 7300918

Claim:
A method of preparing a peptide suitable for direct interception therapy in lowering cholesterol in cells comprising the steps of: a. identifying an amino acid sequence within the sequence of humam hydroxyl-methyl-glutaryl-CoA reductase (HMG CoA), wherein the amino acid sequence represents the maximum cationic or anionic electrical charge within the HMG CoA and is selected from the group consisting of SEQ ID NO: 42, 44, 46, 56, 60 and 64; b. synthesizing a peptide of the amino acid sequence identified in step a; c. recovering the peptide of step b, wherein the synthesized peptide functions as a a direct competitive inhibitor to reduce metabolic interaction of the HMG CoA, and wherein the synthesized peptide functions as a feed-back regulator to reduce the synthesis rate of the HMG CoA.