Patent ID: 8512969

Claim:
A method for evaluating a quality of a batch of a heparin-like glycosaminoglycan preparation, comprising: providing a sample of a batch of a heparin-like glycosaminoglycan preparation; processing the sample by enzymatic digestion or chemical digestion to produce a digested sample; determining the presence or an amount in the digested sample of a signature component selected from the group consisting of ΔUH NAc,6S GH NS,3S,6S ; ΔUH NS,6S GH NS,3S,6S ; ΔUH NAc,6S GH NS,3S ; ΔUH NS,6S GH NS,3S ; ΔU 2S H NS,6S I 2S H NS,6S I 2S H NS,6S IH NAc,6S GH NS,3S,6S ; ΔU 2S H NS,6S IH NS,6S I 2S H NS,6S IH NAc,6S GH NS,3S,6S ; ΔU 2S H NS,6S GH NS,6S I 2S H NS,6S IH NAc,6S GH NS,3S,6S ; ΔU 2S H NS,6S I 2S H NS,6S I 2S H NS,6S IH NAc,6S GMan 3S,6S ; I 2S H NS,6S I 2S H NS,6S IH NAc,6S GH NS,3S,6S ; ΔU 2S H NS,6S I 2S H NS,6S IH NAc,6S GH NS,3S,6S ; I 2S H NS,6S I 2S H NS,6S IH NAc,6S GMan 3S,6S ; ΔU 2S H NS,6S IH NAc,6S GH NS,3S,6S ; I 2S H NS,6S IH NAc,6S GH NS,3S,6S ; ΔU 2S H NS,6S I 2S H NS,6S ; ΔU 2S H NS,6S IH NS,6S ; ΔU 2S H NS,6S GH NS,6S ; ΔU 2S H NS,6S I 2S Man 6S ; IH NAc,6S GMan 3S,6S ; H NAc,6S GMan 3S,6S ; H NS,6S GH NS,3S,6S I 2S H NS,6S,OMe ; H NS,6S GH NS,6S I 2S H NS6,SOMe ; ΔUH NS,6S I 2S H NS,6S,SOMe ; H NS,6S GH NS,6S ; H NS,6S GH NS,3S,6S ; ΔU 2S H NS,6S,OMe ; ΔU 2S H NS,6S ; ΔU 2S H NS ; ΔUH NS,6S ; ΔU 2S H NAc,6S ; ΔUH NS ; ΔU 2S H NAc ; ΔUH NAc,6S and ΔUH NS;3S,6S ; and evaluating the quality of the batch of the heparin-like glycosaminoglycan preparation based on the presence or the amount of the signature component.