Patent ID: 8404722

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein Ar 1 is phenyl or pyridinyl optionally substituted independently with 1-5 substituents, wherein the substituents are selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, halogen, cyano, hydroxy, oxo, —NR a R b and —OR c ; R 1 , R 2 , R 3 , and R 4 are each independently selected from H, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 haloalkyl, halogen, oxo, —C(═O)OR a , —R c OH, —OR c , —NR a R b , NR a C(═O)R b , —C(═O)OR c , —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and S(═O) m R c ; R a , R b , and R c are each independently selected from H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, heterocyclyl, aryl, and heteroaryl; Cy 2 is selected from the group consisting of R 5 is H, C 1-6 alkyl, C 3-6 cycloalkyl, or C 1-6 haloalkyl; Cy 3 is a partially or fully saturated or unsaturated 6-membered monocyclic ring formed of carbon atoms optionally including 1-3 heteroatoms selected from the group consisting of O, N, and S, wherein the ring is optionally substituted independently with 1-5 substituents, wherein the substituents are independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-6 haloalkyl, halogen, cyano, hydroxy, oxo, —C(═O)OR c , —R c OH, —OR c , —NR a R b , NR a C(═O)R b , —C(═O)NR a R b , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c , —S(═O) m NR a R b , and S(═O) m R c , wherein the substituents can be fused forming a 5- or 6-membered saturated or unsaturated cycle optionally containing 1-3 heteroatoms selected from the group consisting of O, N, and S; provided that at least one of Ar 1 or Cy 3 is substituted with at least one substituent or R 5 is not H.