Patent ID: 7202332

Claim:
A method of preparing a compound of Formula II: wherein R is hydrogen, an amino acid side chain, an alkyl group, or an aryl group; R 1 is an amino acid side chain, an alkyl group, or an aryl group; R 2 is an amino acid, peptide, OR, CH 2 NH 2 , an alkyl group, an aryl group, or a group of formula: wherein R 7 is an amino acid, peptide, OR, CH 2 NH 2 , an alkyl group, or an aryl group; R 3 is an amino acid, peptide, OR, CH 9 Mi 2 , an alkyl group, an aryl group, hydrogen, or a group of formula is a single or double carbon-carbon bond; is a single bond and is cis or trans when is a double bond; n is 1 or 2; and m is any number, said method comprising: providing a compound of Formula I: and reacting said compound of Formula I under conditions effective to produce a compound of Formula II; wherein said reacting comprises a ring-closing metathesis reaction.