Patent ID: 6953795

Claim:
A compound of formula I diastereomers, enantiomers or salts thereof where Z is (1) —O—, (2) —S—, (3) —CR 4 R 5 —, (4) —CR 4 R 5 —O—CR 4a R 5a —, (5) —CR 4 R 5 —NR 4b —CR 4a R 5a —, or (6) —S—CR 4 R 5 —, R 1 , R 1b , R 1ac and R 1ad are independently (1) hydrogen or R 6 , (2) —OH or —OR 6 , (3) —C(O) q H or —C(O) q R 6 , where q is 1 or 2, (4) halo, (5) -Z 4 -NR 7 R 8 , R 2 and R 3 are each independently H or -Z 4 -R 6a ; R 6 , R 6a , and R 6b are independently alkyl, cycloalkyl, aryl, or aralkyl, each of which is unsubstituted or substituted with Z 1 , Z 2 and one or more groups Z 3 ; R 4 , R 4a , R 4b , R 5 and R 5a are each independently hydrogen, alkyl, aryl, aralkyl, or cycloalkyl; R 7 and R 8 are each independently hydrogen or -Z 4 R 6b ; Z 1 and Z 2 are each independently (1) hydrogen or Z 6 , (2) —C(O) q H or —C(O) q Z 6 , (3) -Z 4 -NZ 7 Z 8 , where Z 4 is not a single bond, (4) -Z 4 -N(Z 10 )-Z 5 -Z 6 , where Z 4 is not a single bond, (5) -Z 4 -N(Z 10 )-Z 5 -H, where Z 4 is not a single bond, (6) oxo; Z 3 is (1) hydrogen or Z 6 , (2) —OH or —OZ 6 , (3) —C(O) q H or —C(O) q Z 6 , (4) halo, (5) -Z 4 -NZ 7 Z 8 , (6) -Z 4 -N(Z 10 )-Z 5 -Z 6 , (7) -Z 4 -N(Z 10 )-Z 5 -H, (8) oxo; Z 4 and Z 5 are independently (1) a single bond; (2) —(O)—; (3) —S(O) q —; or (4) alkyl; Z 6 and Z 6a are independently (i) alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, aryl, or aralkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is independently substituted by one or more of the groups (2) to (6) of the definition of Z 1 ; Z 7 , Z 8 and Z 10 are each independently hydrogen or -Z 4 -Z 6a .