Patent ID: 8541399

Claim:
A method for preparing a sterile pharmaceutical composition of a steroid comprising: (i) dissolving a non-sterile steroid in a non-aqueous solvent to yield a solution of the steroid, (ii) filtering the solution of (i) to yield a sterile solution, (iii) combining the sterile solution of (ii) with sterile water to form a sterile aqueous suspension, (iv) treating the sterile aqueous suspension of (iii) to obtain a sterile aqueous suspension with a particle size distribution having a mass median diameter less than 10 μm, (v) under sterile conditions combining the sterile aqueous suspension of (iv) with a pharmaceutically acceptable carrier to yield a sterile pharmaceutical composition comprising a sterile aqueous suspension of the steroid having a mass median diameter less than 10 μm, and (vi) storing the sterile pharmaceutical composition of (v) in sterile containers.