Patent ID: 7238705

Claim:
An aporphine derivative having formula (I) wherein one of R 1 and R 2 is hydrogen or acetyl and the other one is selected from the group consisting of (C 3 –C 20 )alkenoyl; halo-(C 3 –C 20 )alkanoyl; (C 3 –C 20 )alkanoyl; (C 4 –C 7 )cycloalkanoyl; (C 3 –C 6 )-cycloalkyl(C 2 –C 16 )alkanoyl; aroyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, cyano, trifluoromethanesulphonyloxy, (C 1 –C 3 )alkyl and (C 1 –C 3 )alkoxy, which latter may in turn be substituted by 1 to 3 halogen atoms; aryl (C 2 –C 16 )alkanoyl which is unsubstituted or substituted in the aryl moiety by 1 to 3 substituents selected from the group consisting of halogen, (C 1 –C 3 )alkyl and (C 1 –C 3 )alkoxy, which latter may in turn be substituted by 1 to 3 halogen atoms; and hetero-arylalkanoyl having one to three heteroatoms selected from O, S and N in the heteroaryl moiety, said heteroaryl moiety being a five or six membered ring, and 2 to 10 carbon atoms in the alkanoyl moiety and which is unsubstituted or substituted in the heteroaryl moiety by 1 to 3 substituents selected from the group consisting of halogen, cyano, trifluoromethane sulphonyloxy, (C 1 –C 3 )alkyl, and (C 1 –C 3 )alkoxy, which latter may in turn be substituted by 1 to 3 halogen atoms; and R 3 is selected from the group consisting of hydrogen; (C 1 –C 4 )-alkyl, which is unsubstituted or substituted by 1 to 3 halogen atoms; cyclopropyl and cyclopropylmethyl, and the physiologically acceptable salts thereof.