Patent ID: 8088816

Claim:
A method of inhibiting abnormal proliferation of cells comprising contacting the cells with a compound of formula III, formula IV, formula VI, or formula VIII in a manner to phosphorylate eIF2α wherein the compound of formula III is: wherein X is selected from the group consisting of oxygen, NH and CH 2 ; and R is selected from the group consisting of 3′-CH 2 CH(CO 2 Me)NH 2 , 3′-CH 2 CH(CO 2 Me)NHFmoc, 3′-t-Bu, 3′-OH, 3′-O(CH 2 ) 3 CHCH 2 , 3′-O(CH 2 ) 4 Br, 3′-O(CH 2 ) 4 NMe 2 , 3′-O(CH 2 ) 4 N 3 , 3′-O(CH 2 ) 4 NH 2 , 3′-CF 3 , 3′-CH 3 , 3′-n-heptyl, 3′-n-nonyl, 3′-i-Bu, 3′-i-propyl, 3′-n-propyl, 3′-n-octyl, 3′-Et, 3′-n-pentyl, 3′-n-Bu, 3′-n-hexyl, 3′-n-cyclopentyl, 3′-n-cyclohexyl, 4-NHSO 2 (4-tBu)Ph and 3′-NHSO 2 (4-tBu)Ph; the compound of formula IV is: wherein R is selected from the group consisting of 4-F, 4-O(CH 2 ) 3 CHCH 2 , 3-Cl, 3-F, 3-Me, 2-Me and 2-OMe; the compound of formula VI is: wherein R 1 is selected from the group consisting of 7-Br, 4-Cl, 5-Br, 5-NO 2 , 5-I, 5-OMe, 5-Cl, 7-CF 3 , 5-NH 2 , 4-Br, 6-Br, H, 7-OMe, 7-I, 5-Et, 7-Et, 4-Et, 6-Et, 5-F, 5-N 3 , 7-COOH, 7-CO 2 H, 4-Cl, 6-Cl and 5-NHSO 2 -1-napthyl; and R 2 is H or 7-CO 2 H; and the compound of formula VIII is: wherein R 1 is selected from the group consisting of H and 7-CO 2 H; R 2 is selected from the group consisting of H, 2-Me, 3′-Me, 3-F and 3-CF 3 ; and R 3 is selected from the group consisting of H, 2-NHFmoc, 2-NHSO 2 CH 2 Ph, 2-NHSO 2 CH 3 , 2-NHSO 2 (4-tBu)Ph, 2-NHSO 2 (4-NHAc)Ph, 2-NHSO 2 (3-CF 3 )Ph, 2-NHSO 2 (4-NO 2 )Ph, 2-NHSO 2 (4-OMe)Ph, 2-NHSO 2 (4-Br)Ph, 2-NHSO 2 (4-I)Ph, 2-NHSO 2 (4-Ph)Ph, 2-NHSO 2 (4-OPh)Ph, 2-NHAc, 2-NHCO(4-tBu)Ph and 3′-NHSO 2 (4-tBu)Ph.