Patent ID: 8779144

Claim:
A bicycloheteroaryl compound having a formula: wherein A is CR 2a R 2b or CO; B and Y are independently selected from CR 2a and CR 2a R 2b ; W, W′ and Z are independently selected from CR 4 and N, provided that all three of W, W′ and Z are not N at the same time; L 1 is a bond, SO, SO 2 or substituted or unsubstituted C 1 -C 5 alkylene; n is 0, 1, 2, 3 or 4; R 1 is selected from a substituted or unsubstituted 3-13 membered cycloalkyl, heterocycloalkyl, aryl and heteroaryl ring; each of R 2a , R 2b , R 2′ and R 2″ is independently selected from hydrogen, halo, and substituted or unsubstituted C 1 -C 6 alkyl; or any of R 2′ and R 2″ join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms; R 3 is selected from hydrogen, a hydrogen bond donor group, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted bicycloaryl, and substituted or unsubstituted bicycloheteroaryl; R 4 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted R 4 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, amino, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted, dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, substituted or unsubstituted heteroalkyl, hydroxyl, nitro, and thio; and the dotted bond is a single or double bond; or a stereoisomer, isotopic variant, or tautomer thereof; or a pharmaceutically acceptable salt or solvate thereof.