Patent ID: 8173624

Claim:
A method for treating a subject for a disease treatable by modulation of RNA (DTMR) associated with splicing of nuclear RNA, comprising: administering to said subject an effective amount of a tetracycline compound of formula (I): wherein R 2 , R 2′ , R 4′ , and R 4″ are each independently hydrogen or alkyl; R 3 , R 10 , R 11 and R 12 are each hydrogen; R 4 is NeR 4′ R 4″ ; R 5 is hydrogen; R 6 and R 6′ are each hydrogen; R 7 is substituted alkenyl, substituted alkynyl, substituted phenyl, substituted or unsubstituted furanyl, acyl, or aminoalkyl; R 8 is hydrogen; R 9 is hydrogen; and X is CR 6′ R 6 ; or a pharmaceutically acceptable salt, ester or enantiomer thereof; such that said DTMR associated with splicing of nuclear RNA is treated, wherein said DTMR associated with splicing of nuclear RNA is spinal muscular atrophy, and further wherein said effective amount is effective to modulate splicing of said subject's nuclear RNA.