Patent ID: RE44733

Claim:
A 6-mercapto-cyclodextrin derivative having the general formula I wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C 1-6 )alkylene, optionally substituted with 1-3 OH groups, or (CH 2 ) o -phenylene-(CH 2 ) p ; o and p are independently 0-4; X is COOH, CONHR 1 , NHCOR 2 , SO 2 OH, PO(OH) 2 , O(CH 2 —CH 2 —O) q —H, OH or tetrazol-5-yl; R 1 is H or (C 1-3 )alkyl; R 2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof; with the exclusion of 6-per-deoxy-6-per-(2-hydroxyethylthio)-β-cyclodextrin; 6-mono-deoxy-6-mono-(2-hydroxyethylthio)-β-cyclodextrin; 6-per-deoxy-6-per-(2-hydroxyethylthio)-γ-cyclodextrin; 6-per-deoxy-6-per-(carboxymethylthio)-β-cyclodextrin; 6-mono-deoxy-6-mono-(carboxymethylthio)-β-cyclodextrin; 6A,6B-dideoxy-6A,6B-bis((o-carboxyphenyl)thio)-β-cyclodextrin; 6A,6B-dideoxy-6A,6B-bis(carboxymethylthiol)-β-cyclodextrin and 6-per-deoxy-6-per-(2,3-dihydroxypropylthio)-β-cyclodextrin.