Patent ID: 7157488

Claim:
A compound of the formula wherein X is —O—; R 1 is selected from the group consisting of phenyl, which phenyl is unsubstituted or substituted with one to three groups independently selected from the group consisting of hydrogen, hydroxy, C 1 –C 4 alkyl, halogen, benzyloxy, carboxy, C 1 –C 4 alkoxycarbonyl, amido, N—(C 1 –C 4 alkyl)amido, sulfonylamido, cyano, trifluoromethyl, trifluoromethoxy, nitro, and phenyl, which phenyl is unsubstituted or substituted with C 1 –C 4 alkyl, C 1 –C 4 alkoxy, halogen, cyano, or trifluoromethyl; and a radical of the formula wherein Q 1 is —NR g — wherein R g is selected from the group consisting of hydrogen and C 1 –C 4 alkyl; R d and R e are taken together with the atoms to which they are attached to form a benzo ring, which benzo ring is unsubstituted or substituted with 1 to 4 substituents independently selected from the group consisting of hydrogen, hydroxy, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, trifluoromethyl, halogen, carboxy, C 1 –C 4 alkoxycarbonyl, amido, N—(C 1 –C 4 alkyl)amido, amino, (C 1 –C 4 alkyl)amino, acylamino wherein the acyl group is selected from the group consisting of C 1 –C 4 alkyl and phenyl; cyano, nitro, sulfonylamido, phenyl, which phenyl is unsubstituted or substituted with C 1 –C 4 alkyl, C 1 –C 4 alkoxy, halogen, cyano, or trifluoromethyl; phenoxy, benzyloxy, —NHS(O) 2 R h , wherein R h is selected from the group consisting of C 1 –C 4 alkyl and phenyl; and —S(O) p R i , wherein p is 0, 1, or 2 and R i is selected from the group consisting of C 1 –C 4 alkyl and phenyl, which phenyl is unsubstituted or substituted with C 1 –C 4 alkyl, C 1 –C 4 alkoxy, halogen, cyano, or trifluoromethyl; and R f is selected from the group consisting of hydrogen, C 1 –C 4 alkyl, C 1 –C 4 alkoxy, trifluoromethyl, and halogen; R 2 is selected from the group consisting of hydrogen and C 1 –C 3 alkyl; R 3 is selected from the group consisting of hydrogen, fluoro, and methyl; R 4 is selected from the group consisting of C 2 –C 4 alkyl, and fluorinated C 2 –C 4 alkyl; and pharmaceutically acceptable salts thereof.