Patent ID: 8138361

Claim:
A compound of formula 1: or pharmaceutically acceptable compound, wherein R 1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or acyl; R 2 is alkyl or aryl, wherein the aryl group is optionally substituted with one to three electron withdrawing or electron donating groups; R 7 is H or OR 7a where R 7a is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —COR 7b , —CONR 7c R 7d or is hydroxyl protecting group, wherein R 7b is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, and R 7c and R 7b are each independently selected as follows: a) R 7c and R 7d are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, or b) R 7c and R 7d together with the nitrogen atom form an optionally substituted 5-7 membered heterocyclic or heteroaryl ring; R 9 is ═O, or —OR 7a ; X is NR x R y , where R x is hydrogen or alkyl and R y is carboxyalkyl, carboxyheteroalkyl, carboxyalkenyl, carboxyalkynyl, carboxycycloalkyl, carboxyheterocyclyl, carboxyaryl, carboxyheteroaryl or aminoheteroalkyl, wherein the amino group is optionally protected with a protecting group; R 14 is hydrogen, hydroxyl or alkoxy; R 3a is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 4a is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or is hydroxyl protecting group; R 5a is —COR 7b , —COOR 7b , or CONR 7c R 7d ; and R 1 , R 2 , R 3a , R 4a , R 5a , R 7a , R 7b , R 7c , R 7d , R y , and R 14 are unsubstituted or substituted with 1-4 substituents Q 1 , wherein each Q 1 is independently halo, pseudohalo, hydroxy, oxo, thia, nitrile, amino, nitro, formyl, mercapto, hydroxycarbonyl, hydroxycarbonylalkyl, alkyl, haloalkyl, aminoalkyl, diaminoalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycclylalkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, aralkyloxycarbonyl, aralkoxycarbonylamino, aminocarbonyl, alkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, cycloalkoxy, aralkoxy, alkylamino, dialkylamino, haloalkylamino, arylamino, diarylamino or alkylarylamino with the proviso that when R 1 is hydrogen, R 2 is aryl, R 3a is aryl, R 4a is hydrogen, R 5a is —COR 7b , R 7b is aryl, R 7 is —OH, and R 9 is ═O, X is NR x R y , and Rx is hydrogen, then R y is not aminoheteroalkyl.