Patent ID: 7439240

Claim:
A compound of formula (I): in which: X is N; Y is :CH, CO, CH 2 or :CNR 2 R 3 , where R 2 and R 3 are independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; R is aryl or heteroaryl optionally substituted by halogen, amino, hydroxy, cyano, nitro, trifluoromethyl, carboxy, CONR 5 R 6 , SO 2 NR 5 R 6 , SO 2 R 4 , NHSO 2 R 4 , NHCOR 4 , ethylenedioxy, methylenedioxy, C 1-6 alkyl, C 1-6 alkoxy, SR 4 or NR 5 R 6 where R4 is hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl, R 5 and R 6 are independently hydrogen, C 1-6 alkyl or together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated ring optionally containing a further O, S or NR 4 group; or R is C 1-6 alkyl or C 3-6 cycloalkyl, R 1 is a group Y(CH 2 )pR 7 where p is 0, 1 or 2 and Y is O or NR 8 where R 8 is hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; and R 7 is a 5- or 6-membered saturated ring containing one or more O, S or N atoms, aryl or a heteroaryl group containing one to four heteroatoms selected from O, S or N, the saturated ring, aryl and heteroaryl groups all being optionally substituted by halogen, amino, hydroxy, cyano, nitro, trifluoromethyl, carboxy, CONR 5 R 6 , SO 2 NR 5 R 6 , SO 2 R 4 , NHSO 2 R 4 , NHCOR 4 , C 1-6 alkyl, C 1-6 alkoxy, SR 4 or NR 5 R 6 where R4 is hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl, R 5 and R 6 are independently hydrogen, C 1-6 alkyl or together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated ring optionally containing a further O, S or NR 4 group; or R 1 is a group NR 9 R 10 where R 9 and R 10 are independently hydrogen or C 1-6 alkyl, or R 9 and R 10 together with the nitrogen atom to which they are attached form a 5 or 6-membered saturated ring optionally containing a further O, S or N atom and optionally substituted by a second NR 9 R 10 where R 9 and R 10 are independently hydrogen or C 1-6 alkyl or R 9 and R 10 together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated ring optionally containing a further O, S or NR 4 , CO 2 C 1-6 alkyl, CONR 11 R 12 where R 11 and R 12 are independently hydrogen or C 1-6 alkyl, aryl or heteroaryl group optionally substituted by halogen, amino, hydroxy, cyano, nitro, trifluoromethyl, carboxy, CONR 5 R 6 , SO 2 NR 5 R 6 , SO 2 R 4 , NHSO 2 R 4 , NHCOR 4 , C 1-6 alkyl, C 1-6 alkoxy, SR 4 or NR 5 R 6 where R4 is hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl, R 5 and R 6 are independently hydrogen, C 1-6 alkyl or together with the nitrogen atom to which they are attached form a 5- or 6-membered saturated ring optionally containing a further O, S or NR 4 group; and pharmaceutically acceptable salts or solvates thereof.