Patent ID: 8703717

Claim:
An isolated fusion protein, comprising a growth hormone (GH) sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO: 1, wherein said growth hormone is linked to an extended recombinant polypeptide (XTEN) comprising a sequence which is at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NOS: 67, 71, 74, and 75, wherein the XTEN is further characterized in that: (a) the XTEN sequence is substantially non-repetitive such that (i) the XTEN sequence contains no three contiguous amino acids that are identical unless the amino acids are serine residues, or (ii) at least 80% of the XTEN sequence consists of non-overlapping sequence motifs, each of the sequence motifs comprising from 9 to 14 amino acid residues, wherein any two contiguous amino acid residues does not occur more than twice in each of the sequence motifs; or it has a subsequence score of less than 10; and (b) the sum of glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P) residues constitutes more than 90% of the total amino acid residues of the XTEN.