Patent ID: 8470590

Claim:
A multiwell plate device, comprising: a frame having a top surface and defining an opening therethrough with said frame being disposed in a predetermined orientation; a substrate engaging member disposed adjacent at least a portion of the opening and having a top surface and an opposite bottom surface, each of the top surface and bottom surface of said substrate engaging member being located below the top surface of said frame; a substrate having a reaction surface and an opposite bottom surface and being configured to engage the substrate engaging member and; a multiwell structure supported by said substrate and having a plurality of bottomless wells formed therein, wherein in an upright orientation of said substrate and said multiwell structure with said multiwell structure located above said substrate, said multiwell structure and said substrate are inserted into the opening from beneath said frame, with said frame disposed in the predetermined orientation, with said reaction surface of said substrate engaging the bottom surface of said substrate engaging member, and further wherein in an inverted orientation of said substrate and said multiwell structure with said multiwell structure located beneath said substrate, said multiwell structure and said substrate are inserted into the opening from above said frame, with said frame disposed in the predetermined orientation, with said reaction surface of said substrate engaging the top surface of said substrate engaging member.