Patent ID: 7442376

Claim:
An isolated glycosylated or nonglycosylated composition of the formula β 2 ≈α-(linker) m -β 1 (1); or β 1 -(linker) m -α≈β 2 (2) wherein each of β 1 and β 2 has the amino acid sequence of the β subunit of a vertebrate glycoprotein hormone, or a variant thereof; “α” has the amino acid sequence of the α subunit of a vertebrate glycoprotein hormone or a variant thereof; “linker” is a linker moiety; and “≈” is a noncovalent link between α and β 2 ; m is 0 or 1; wherein one of β 1 and β 2 confers agonist activity and the other confers antagonist activity.