Patent ID: 8686158

Claim:
A palladium complex of formula (I): wherein: the dashed line represents the presence or absence of a bond; Pd has a valency of +4; n is an integer between 0 and 4, inclusive; m is an integer between 0 and 3, inclusive; each occurrence of R A is independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; â€”ORâ€²; â€”C(â•O)Râ€²; â€”CO 2 Râ€²; â€”CN; â€”SCN; â€”SRâ€²; â€”SORâ€²; â€”SO 2 Râ€²; â€”NO 2 ; â€”N(Râ€²) 2 ; â€”NHC(O)Râ€²; or â€”C(Râ€²) 3 ; wherein each occurrence of Râ€² is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety; an aryl moiety; a heteroaryl moiety; alkoxy; aryloxy; alkylthio; arylthio; amino, alkylamino, dialkylamino, heteroaryloxy; or heteroarylthio moiety; wherein two R A may be taken together to form a substituted or unsubstituted carbocyclic, heterocyclic, aryl or heteroaryl ring; each occurrence of R B is independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; â€”ORâ€³; â€”C(â•O)Râ€³; â€”CO 2 Râ€³; â€”CN; â€”SCN; â€”SRâ€³; â€”SORâ€³; â€”SO 2 Râ€³; â€”NO 2 ; â€”N(Râ€³) 2 ; â€”NHC(O)Râ€³; or â€”C(Râ€³) 3 ; wherein each occurrence of Râ€³ is independently a hydrogen, a protecting group, an aliphatic moiety, a heteroaliphatic moiety, an acyl moiety; an aryl moiety; a heteroaryl moiety; alkoxy; aryloxy; alkylthio; arylthio; amino, alkylamino, dialkylamino, heteroaryloxy; or heteroarylthio moiety; each occurrence of R C is independently hydrogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; wherein R C and R B may be taken together to form a substituted or unsubstituted heterocyclic or heteroaryl ring; and wherein R C and R A may be taken together to form a substituted or unsubstituted carbocyclic, heterocyclic, aryl or heteroaryl ring; R D1 , R D2 , R D3 , and R D4 are each a substituted or unsubstituted pyrazolyl ring; Z âˆ’ is an anion such as halide, acetate, tosylate, azide, tetrafluoroborate, tetraphenylborate, tetrakis(pentafluorophenyl)borate, [B[3,5-(CF 3 ) 2 C 6 H 3 ] 4 ] âˆ’ , hexafluorophosphate, phosphate, sulfate, perchlorate, trifluoromethanesulfonate or hexafluoroantimonate; and F comprises 18 F or 19 F.