Patent ID: 7244763

Claim:
A compound having a Formula (I), a pharmaceutically acceptable salt, ester, amide or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug wherein: X 0 and X 1 are each independently absent, O, S, NR 4 , —CH 2 —CH 2 —, —CH═CH, or —C≡C—; Ar 1 and Ar 2 are each independently absent or unsubstituted or substituted aryl or heteroaryl, is absent; or when present, is a saturated or unsaturated hydrocarbon chain which is substituted or unsubstituted, wherein said chain has from 1 to 4 atoms so that Ar 1 , X 1 , (CH 2 ) r and Ar 2 , together form a five to eight membered ring; T is a saturated or unsaturated, substituted or unsubstituted hydrocarbon chain or hydrocarbon-heteroatom chain having from 3 to 6 atoms wherein the carbon atom of position 1 is connected to the carbon atom of position 2 to form a five to eight member ring wherein the is attached to a substitutionally available position of said ring; X 2 is absent, O, S, or NR 4 ; R 1 , R 2 , and R 3 are independently hydrogen, lower alkyl, lower alkoxy, lower thioalkoxy, —O(CH 2 ) p CF 3 , halogen, nitro, cyano, —OH, —SH, —CF 3 , S(O) p Alkyl, S(O) p Aryl, —(CH 2 ) m OR 4 , or —(CH 2 ) m NR 5 R 6 , COR 4 , —CONR 5 R 6 , —CO 2 R 4 , or —NR 5 R 6 or R 1 and R 2 are joined together to form a substituted or unsubstituted, saturated or unsaturated cyloalkyl or heterocycloalkyl ring; R 4 is hydrogen, alkyl, alkenyl, alkynyl, acyl, SO 2 Aryl, SO 2 Alkyl or aryl; R 5 and R 6 are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, SO 2 Alkyl aryl or SO 2 Aryl, or joined together to form a 4 to 7 member ring having 0 to 3 heteroatoms; R 7 and R 8 are independently H, lower alkyl, halo, or R 7 and R 8 taken together form a 3–6 membered hydrocarbon ring, optionally containing a heteroatom; m is an integer from 0 to 5; n is an integer from 0 to 5; p is an integer from 0 to 2; q is an integer from 0 to 10; and r is an integer from 0 to 10.