Patent ID: 7482392

Claim:
A method for preparing 2-hydroxy-1-{4-[4-(2-hydroxy-2-methyl-propionyl)-phenoxy]-phenyl}-2-methyl-propan-1-one comprising the steps of: a) reacting diphenylether with an acylating agent by means of a Friedel-Crafts reaction catalyzed by a Lewis acid to produce a reaction product; and b) reacting the reaction product with a hydrated base, at a temperature of from about 10° C. to about 50° C. to produce 2-hydroxy-1-{4-[4-(2-hydroxy-2-methyl-propionyl)-phenoxy]-phenyl}-2-methyl-propan-1-one; wherein the acylating agent is selected from the group consisting of alpha-bromoisobutyryl bromide, alpha-chloroisobutyryl chloride, and mixtures thereof.