Patent ID: 7479501

Claim:
A compound of formula (I): wherein:— Het is a five heteroaromatic ring of the formula in which R 1 is optionally substituted aryl, and R 2 is 4-pyridyl; wherein aryl is selected from: phenyl and naphthyl; and aryl optional substitution is with one or more substituents selected from: acyl, acylamino, alkoxy, ailcoxycarbonyl, alkylenedioxy, alkylsulphinyl, alkylsulphonyl, allcylthio, aroyl, aroylamino, aryl, arylailcyloxy, arylailcyloxycarbonyl, arylallcyltbio, aryloxy, aryloxycarbonyl, arylsulphinyl, arylsulphonyl, arylthio, carboxy, cyano, halo, hydroxy, nitro, trifluoromethyl, Y 3 Y 4 N—, Y 3 Y 4 NCO—, Y 3 Y 4 NSO 2 —, Y 3 Y 4 N—C 2-6 alkylene-Z 1 - (where Z 1 is O, NR 5 or S(O)n), alkylC(═O)—Y 3 N—, alkylSO 2 —Y 3 N—or alkyl optionally substituted with aryl hydroxy, or Y 3 Y 4 N—; X 2 is CH, X 3 is C, X 4 is N and X 5 is N; R 3 represents a group -L 1 -R 6 ; R 4 represents hydrogen, alkyl or hydroxyalkyl; or R 3 and R 4 , when attached to the same carbon atom, may form with the said carbon atom a cycloalkyl, cycloalkenyl or heterocycloalkyl ring or a group C═CH 2 ; R 5 represents hydrogen or alkyl; R 6 is hydrogen, alkyl, azido, hydroxy, alkoxy, aryl, arylalkyloxy, aryloxy, carboxy an acid bioisostere selected from the group consisting of C(═O) NHOH, —C(═O)—CH 2 OH, —C(═O)—CH 2 SH, C(═O) NH—CN, sulpho, phosphono, alkylsuiphonylcarbamoyl, arylsulphonylcarbamoyl, N methoxycarbamoyl, or 3 hydroxy-3-cyclobutene-1 ,2-dione, cycloalkyl, cycloalicyloxy, nitro, —NY 1 Y 2 , —N(R 7 )—C(=Z)—R 8 , —N(R 7 )—C(=Z)-L 2 -R 9 ,—NH—C(=Z)—NH—R 8 , —NH—C(=Z)—NH-L 2 -R 9 , —N(R 7 )—SO 2 -R 8 , —N(R 7 )—SO 2 -L 2 -R 9 , —S(O) n R 10 , —C(=Z)—NY 1 Y 2 or —C(=Z)—OR 10 ; R 7 is hydrogen, alkyl, aryl, arylalkyl, or cycloalkyl; R 8 is alkyl, alkoxy, aryl, arylalkyloxy, or cycloalkyl,; R 9 is alkoxy, aryl, arylalkyloxy, arylalkyloxycarbonylamino, carboxy, an acid bioisostere selected from the group consisting of C(═O) NHOH, —C(═O)—CH 2 OH, -C(=O)-CH2SH, C(═O) NH—CN, suipho, phosphono, alkylsuiphonylcarbamoyl, arylsulphonylcarbamoyl, N methoxycarbamoyl, 3 hydroxy-3-cyclobutene-1 ,2-dione, cycloalicyl, cyano, halo, hydroxy or —NY 3 Y 4 ; R 10 is alkyl, aryl, arylalkyl, or cycloalkyl; L 1 represents a direct bond or a straight- or branched-chain alkylene linkage containing from 1 to 6 carbon atoms and optionally substituted by halogen, hydroxy, alkoxy or oxo; L 2 is a straight- or branched-chain alkylene linkage containing from 1 to 6 carbon atoms; Y 1 and Y 2 are independently hydrogen, alkenyl, alkynyl, aryl, cycloalkyl, or alkyl optionally substituted by alkoxy, aryl, cyano, cycloalkyl, hydroxy, oxo, —CO 2 R 7 , —CONY 3 Y 4 or —NY 3 Y 4 ; Y 3 and Y 4 are independently hydrogen, alkenyl, alkyl, alkynyl, aryl, arylalkyl, or cycloalkyl; Y 5 is hydrogen, alkyl, aryl, arylalkyl, —C(=Z)R 10 , —C(=Z)OR 10 or —SO 2 R 10 ; Z is an oxygen or sulphur atom; m is zero or an integer 1 or 2; and n is zero or an integer 1 or 2; or an N-oxides thereof, or a pharmaceutically acceptable salt thereof.