Patent ID: 7468419

Claim:
A compound of formula I or a pro-drug, or an ester or a pharmaceutically acceptable salt thereof: and A is of the formula: wherein: Q is where i) X is selected from hydrogen, halogen, C 1 -C 6 alkyl, or aryl; ii) one of Y and Z is selected from: hydrogen, deuterium, halogen, or methyl and the other is independently selected from: a) halogen; b) R 1 , where R 1 is selected from: 1) hydrogen; 2) deuterium; 3) C 1 -C 6 alkyl, optionally substituted with halogen, TMS, aryl, heterocycloalkyl, or heteroaryl; 4) C 2 -C 6 alkenyl, optionally substituted with halogen, TMS, aryl, heterocycloalkyl, or heteroaryl; 5) C 2 -C 6 alkynyl, optionally substituted with halogen, TMS, aryl, heterocycloalkyl, or heteroaryl; 6) C 3 -C 12 cycloalkyl; 7) substituted C 3 -C 12 cycloalkyl; 8) aryl; 9) substituted aryl; 10) heterocycloalkyl; 11) substituted heterocycloalkyl; 12) heteroaryl; or 13) substituted heteroaryl; c) —C(O)OR 1 , where R 1 is as previously defined; d) —C(O)OCH 2 —V—R 1 , where R 1 is as previously defined and V is —O— or —S—; e) —C(O)N(R 3 )(R 4 ), where R 3 and R 4 are independently selected from R 1 as previously defined; f) —C(O)SR 1 , where R 1 is as previously defined; g) —C(O)OCH 2 OC(O)R 1 , where R 1 is as previously defined; h) —C(S)OR 1 , where R 1 is as previously defined; i) —C(S)SR 1 , where R 1 is as previously defined; j) R 2 , where R 2 is selected from: 1) C 1 -C 6 alkyl-M-R 1 , where R 1 is as previously defined and M is absent or selected from: i. —NH—; ii. —N(CH 3 )—; iii. —S—; iv. —S(O) n —, where n=0, 1, or 2; or v. —O—; 2) C 2 -C 6 alkenyl-M-R 1 , where R 1 and M are as previously defined; or 3) C 2 -C 6 alkynyl-M-R 1 , where R 1 and M are as previously defined; k) Or in the alternative, Y and Z are taken together with the carbon atom to which they are attached to form a C 3 -C 12 cycloalkyl moiety; and iii) G is independently selected from halogen, TMS, R 1 or R 2 as previously defined; B is selected from: i) -αAbu-; ii) -Val-; iii) -Thr-; or iv) -Nva-; U is selected from: i) -(D)Ala-; ii) -(D)Ser-; iii) -[O-(2-hydroxyethyl)(D)Ser]-; iv) -[O-(acyl)(D)Ser]-; or v) -[O-(2-acyloxyethyl)(D)Ser]-; and W is selected from hydrogen or a hydroxy protecting group.