Patent ID: 7851623

Claim:
A process for the manufacture of a compound of Formula I: from a compound of the Formula IX: wherein R 4 is a protecting group selected from benzyl, C 1-4 alkoxybenzyl, dialkoxybenzyl, alkylbenzyl, di-C 1-4 alkylbenzyl, tert-butyl, 1,1-dimethylpropyl, allyl, C 1-4 alkylallyl and methoxyethoxymethyl, which process comprises the steps of: (f) reaction of a compound of Formula IX with a derivatizing agent, in the presence of a suitable solvent and in the presence of a suitable base, to form a compound of Formula X wherein L 1 is a leaving group; (g) reacting the compound of the Formula X with a compound of Formula II (2-methyl-4-fluoro-5-hydroxy-indole) to form a compound of the Formula VIII, in the presence of a suitable solvent and in the presence of sodium hydroxide; (h) isolating the compound of the Formula VIII; (j) removing R 4 from the compound of the Formula VIII to form the compound of the Formula XI or a salt thereof; and (k) reacting the compound of the Formula XI with a compound of the Formula XII or a compound of Formula XIII wherein L 2 is a leaving group and X − is a suitable counter ion in the presence of a suitable base to provide a compound of the Formula I or a salt thereof; and thereafter the compound of the Formula I obtained in the form of the free base may be converted into a salt form and the compound of the Formula I obtained in the form of a salt may be converted into the free base or into the form of an alternative salt.