Patent ID: 7214710

Claim:
A prodrug having the following formula (I): R-(DRUG) (I) wherein the DRUG is a drug molecule covalently linked to R, and R is represented by the following formula (II): wherein Y is selected from the group consisting of O, S and NR 8 , where R 8 is selected from the group consisting of H or C 1 –C 4 alkyl, C 3 –C 4 branched alkyl and C 3 –C 4 cycloalkyl; X is O or S; R 1 is selected from the group consisting of OH, OR 9 , O—CH 2 —COOH, NH 2 and + NH 3 Z − where R 9 is selected from the group consisting of C 1 –C 4 alkyl, C 3 –C 4 branched alkyl, and C 3 –C 4 cycloalkyl and where Z − is a pharmaceutically acceptable salt anion; R 2 is selected from the group consisting of H, C 1 –C 4 alkyl, C 1 –C 4 hydroxyalkyl; R 3 is selected from the group consisting of H, C 1 –C 4 alkyl, C 1 –C 4 hydroxyalkyl; R 4 is selected from the group consisting of H, C 1 –C 4 alkyl, C 1 –C 4 hydroxyalkyl; R 5 is selected from the group consisting of H, C 1 –C 4 alkyl, C 1 –C 4 hydroxyalkyl; R 6 is selected from the group consisting of H, C 1 –C 4 alkyl, C 1 –C 4 hydroxyalkyl; R 7 is selected from the group consisting of H, C 1 –C 4 alkyl, C 1 –C 4 hydroxyalkyl; and n is a number from 1 to 12.