Patent ID: 8242124

Claim:
A compound of Formula I, including pharmaceutically acceptable salts thereof: wherein A is: wherein B is selected from the group consisting of: and further wherein a is selected from the group consisting of H, halogen and methoxy; b and c are selected from the group consisting of H and halogen; d is selected from the group consisting of H, halogen, methoxy and Group C; e is H; f and g are selected from the group consisting of H, (C 1 -C 4 ) alkyl, and (C 3 -C 6 ) cycloalkyl group, and wherein said alkyl or cycloalkyl group is optionally substituted with one to three substitutions selected from the group of F, OH, OR, NR 1 R 2 , COOR, and CONR 1 R 2 ; h and i are selected from the group consisting of H, (C 1 -C 4 ) alkyl, and (C 3 -C 6 ) cycloalkyl group, wherein said alkyl or cycloalkyl group is optionally substituted with one to three substitutions selected from the group of F, OH, OR, NR 1 R 2 , COOR, and CONR 1 R 2 ; j and k are selected from the group consisting of H, F, (C 1 -C 4 ) alkyl, and (C 3 -C 6 ) cycloalkyl group, and wherein said alkyl or cycloalkyl group is optionally substituted with one to three substitutions selected from the group of F, OH, OR, NR 1 R 2 , COOR, and CONR 1 R 2 ; l, m and n are selected from the group consisting of H, OH, CN, (C 1 -C 4 ) alkyl optionally substituted with one to three substitutions selected from F, OH, OR, NR 1 R 2 , COOR, CONR 1 R 2 , (C 3 -C 6 ) cycloalkyl optionally substituted with one to three substitutions selected from F, OH, OR, NR 1 R 2 , COOR, CONR 1 R 2 , OR, halogen (attached to carbon only), NR 1 R 2 , COOR, CONR 1 R 2 ; Ar is selected from the group consisting of phenyl and pyridinyl; wherein said phenyl and pyridinyl are independently optionally substituted with one to three same or different halogens or from one to three same or different substituents selected from Group E; Group C is selected from the group consisting of COOR, CONR 1 R 2 , and Group D; Group D is selected from the group consisting of pyrazinyl and triazolyl; wherein said pyrazinyl and triazolyl are independently optionally substituted with one to three same or different halogens or from one to three same or different substituents selected from Group E; Group E is selected from the group consisting of OH, OR, CN, COOR, CONR 1 R 2 , (C 1 -C 4 ) alkyl, (C 3 -C 6 ) cycloalkyl, and wherein said alkyl or cycloalkyl group is optionally substituted with one to three substitutions selected from the group of F, OH, OR, NR 1 R 2 , COOR, and CONR 1 R 2 ; R, R 1 and R 2 are independently H, (C 1 -C 4 ) alkyl, (C 3 -C 6 ) cycloalkyl group; and wherein R 1 and R 2 can be connected by carbon, oxygen, nitrogen or sulfur atom to form a ring.