Patent ID: 6946458

Claim:
A N-1 thiolated monobactam compound of the formula: or a salt or hydrate thereof, wherein: R 1 is alkyl, cycloalkyl, heteroalkyl, aryl, or heteroaryl; X(R 2 ) n is hydrogen, methoxy, acetoxy, or phenoxy; R 3 is aryl(C 1 -C 6 )alkyl, aryl(C 2 -C 6 )alkenyl, aryl, heteroalkyl, heteroaryl; wherein any aryl or heteroaryl is optionally substituted with halo, nitro, cyano, hydroxyl, trifluoromethoxy, (C 1 -C 15 )alkyl, (C 2 -C 15 )alkenyl, (C 2 -C 15 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 15 )alkoxy, (C 3 -C 8 )cycloalkyl-(C 2 -C 15 )alkenyl, (C 3 -C 8 )cycloalkyl(C 2 -C 15 )alkynyl, (C 1 -C 15 )alkoxy, (C 1 -C 15 )alkanoyl, (C 1 -C 15 )alkanoyloxy, C(O)O(C 1 -C 6 )alkyl, C(═O)N((C 1 -C 6 )alkyl) 2 , or N((C 1 -C 6 )alkyl) 2 ; R 4 is hydrogen; R 5 is hydrogen; and excluding the compounds 3-methoxy-1-methylthio-4-phenylethynyl-2-oxoazetidine, and 1-thiomethyl-3-methoxy-4-(O-acctyl)phenylethynyl-2-oxoazetidine.