Patent ID: 8685983

Claim:
A method of treating cancer in a subject using a compound of Formula I Râ€”Xâ€”Wâ€”Yâ€”R 1 I enantiomers, diastereomers, salts and N-oxides thereof, wherein R is Z is selected from N or CR 7 ; Z 1 is selected from N or CR 7 ; W is a substituted or unsubstituted phenyl; X is O; Y is â€”NR a C(â•O)â€”(CR 3 R 4 ) p â€”; R a is selected from H, alkyl, heterocyclyl, aryl, arylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; wherein R a is optionally substituted; R 1 is wherein R b is independently selected at each occurrence from H, optionally substituted arylalkyl, optionally substituted C 1-6 -alkyl, optionally substituted C 6-10 aryl: wherein R c is one or more substituents selected from H, methyl, isopropyl, and tert-butyl, R 3 and R 4 are each independently selected from H, alkyl, aryl, and heterocyclyl, R 7 is selected from H, halo, and alkyl; R 8* is one or more substituents independently selected at each occurrence from â€”NR a C(â•O)â€”R 5 , R 5 is independently selected at each occurrence from H, alkyl, heterocyclylalkyl, cycloalkylalkyl, aryl and heterocyclyl; and p is 0, 1, 2, or 3; wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, and alkoxy moiety of any R, R 1 , R 3 , R 4 , R 5 , R 7 , R 8* , and R a is optionally independently substituted with one or more groups independently selected at each occurrence from halo, oxo, (C 1 -C 6 )alkylamino, â€”NHâ€”Nâ•NH, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, heterocyclic, and heteroaryl, wherein cancer is selected from the group consisting of epidermoid carcinoma, glioma and gastric adenocarcinoma.