Patent ID: 8133506

Claim:
A pharmaceutical composition comprising a plurality of timed pulsatile release and rapid release particles, wherein: the timed pulsatile release particles each comprise a core coated with a timed pulsatile release layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid wherein the weakly basic drug is disposed over the organic acid and wherein a sustained release layer comprising a water insoluble polymer optionally in combination with a water soluble polymer or an enteric polymer, is disposed between the weakly basic drug and the organic acid; the rapid release particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt. % of the weakly basic, poorly soluble drug in about 15 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2—paddles@50 RPM and a two-stage dissolution medium at 37° C. (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).