Patent ID: 8163550

Claim:
A method of generating an enhanced immune response in a subject, the method comprising administering to the subject: (a) an immunogenic stimulus, wherein the immunogenic stimulus is (i) a dendritic cell comprising a major histocompatibility complex (MHC) molecule with a peptide-epitope bound thereto, wherein the peptide-epitope is a fragment of a TAA or a fragment of a polypeptide produced by an infectious microorganism, (ii) a dendritic cell that has been incubated with tumor cells, a tumor cell lysate, a tumor-associated antigen (TAA), a peptide-epitope of a TAA, or a heat shock protein bound to a peptide-epitope expressed by a tumor cell, (iii) a tumor cell that is transfected with or transformed with a nucleic acid encoding a cytokine or a growth factor, or (iv) a hybrid cell; and (b) an agonistic antibody, or antibody fragment, that binds to 4-1BB.