Patent ID: 7737280

Claim:
A process for preparing N-[(S)-1-Azabicyclo(2,2,2)oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalene carboxamide (the free base of Cp 9563) of the following formula comprising reacting a (5,6,7,8)-tetrahydro- 1-naphthylenecarboxide (Cp 9588) having the formula, a salt of (S)-3-aminoquinuclidine (Cp 9771) having the formula: and an inorganic base in a solvent mixture comprising water and a water-immiscible organic solvent to obtain said N-[(S)-1-Azabicyclo(2,2,2)oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalene carboxamide; wherein X is a leaving group selected from the group consisting of: halogen, OCOR, OCOOR, and OSO 2 R, wherein R is a C 1 -C 4 alkyl, and HD is an acid; wherein the inorganic base is selected from the group consisting of alkaline hydroxide, alkaline carbonates, and alkaline hydrogen carbonates.