Patent ID: 7279562

Claim:
A rapamycin conjugate represented by formula I, or a salt thereof: wherein R 1 and R 2 are each, independently, hydrogen or —(R 3 -L-R 4 ) a —; L is a linking group; R 3 is selected from the group consisting of carbonyl, —S(O)—, —S(O) 2 , —P(O) 2 —, —P(O)(CH 3 )—, —C(S)—, and —CH 2 C(O)—; R 4 is a selected from the group consisting of carbonyl, —NH—, —S—, —CH 2 —, and —O—; a=1-5; x=0-1; y=0-1; z is from about 1 to about 120; and Carrier is immunogenic carrier material, detector carrier material, or a solid matrix, with the proviso that R 1 and R 2 are both not hydrogen; and further provided that when a is greater than 1, each L group can be the same or different; and still further provided that x is 0 if R 1 is hydrogen and y is 0 if R 2 is hydrogen, and if x and y are both 1, the Carrier moiety is the same in both cases.