Patent ID: 6849640

Claim:
A compound of formula (I): wherein: R 1 , R 2 , R 3 , and R 4 are independently hydrogen, halo, —CF 3 , —OCF 3 , —CN, —NO 2 , C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, —OR 8 , —SR 8 , —C(═O)Ar, Ar, or —C 1-8 alkyleneAr, provided that at least one of R 1 , R 2 , R 3 , or R 4 is aryl; R 5 is hydrogen, C 1-8 alkyl, C 3-8 cycloalkyl, aryl, heteroaryl, Het, R 10 C(═O)—, R 10 OC(═O)—, R 10 SO 2 —, R 9 R 8 NC(═O)—, R 10 C(═S)—, R 10 SC(═O)—, R 9 R 8 NC(═S)—, R 10 SO 2 —, R 9 R 8 NSO 2 —, R 10 S(═O)—, R 9 R 8 NS(═O)—, R d C 1-8 alkylene-, or R d C 1-8 alkyleneC(═O)—; R 6 is hydrogen or C 1-4 alkyl; R 7 is hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, haloC 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 1-8 alkanoyl, haloC 1-8 alkanoyl, —C(═O)OR 8 , —C(═O)Ar , Ar, or —C 1-8 alkylenearyl; each R 8 and R 9 is independently hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, haloC 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, Ar, or —C 1-8 alkyleneAr; or R 8 and R 9 together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each R 10 is independently hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, haloC 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, Ar, or —C 1-8 alkyleneAr; the bond represented by - - - is absent or present; each Ar is independently aryl or heteroaryl; each C 1-8 alkylene is optionally unsaturated; each aryl or heteroaryl is optionally substituted with one or more C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, halo, —CN, —NO 2 , —OR c , —CF 3 , —OCF 3 , —SR c , —SO 2 R c , —SO 2 NR a R b , —NR a R b , —C(═O)NR a R b , —NR c C(═O)R c , —NR c C(═O)NR a R b , —CO 2 R c , or —C(═O) R c ; R a and R b are each independently hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, or C 3-8 cycloalkenyl; or R a and R b together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring; each R c is independently hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, or C 3-8 cycloalkenyl; R d is aryl, Het, heteroaryl, R 10 CO 2 —, R 10 C(═O)—, R 10 OC(═O)—, R 10 O—, R 10 OC 1-8 alkyleneO—, R 10 S—, R 10 C(═S)—, R 10 S(═O)—, R 10 SC(═O)—, R 10 C(═O)N(R 10 )—, R 10 C(═S)N(R 10 )—, R 9 R 8 N—, R 9 R 8 NC(═O)—, R 9 R 8 NC(═S)—, R 9 R 8 NS(═O)—, R 9 R 8 NSO 2 —, R 10 S(═O)N(R 10 )—, R 10 SO 2 N(R 10 )—; or a pharmaceutically acceptable salt thereof.