Patent ID: 7741271

Claim:
A method of treating a Th2-rnediated disorder, or of reducing the frequency, severity or onset of symptoms of the Th2-mediated disorder, in a subject in need of such treatment, the method comprising administering to the subject a therapeutically effective amount of an agent, said agent comprising a polypeptide consisting essentially of (i) amino acids 31-133 of SEQ ID NO: 3; (ii) amino acids 31-134 of SEQ ID NO: 4; (iii) a conservative substitution polypeptide having an amino acid sequence at least 95% identical to amino acids 31-133 of SEQ ID NO: 3, and wherein the polypeptide binds to human Tim-1 (SEQ ID NO: 1) and increases the activity of Tim-1 to signal into T cells; or (iv) a conservative substitution polypeptide having an amino acid sequence at least 95% identical to amino acids 31-134 of SEQ ID NO: 4, and wherein the polypeptide binds to mouse Tim-1 (SEQ ID NO: 2) and increases the activity of Tim-1 to signal into T cells.