Patent ID: 8153618

Claim:
A method of coating an animal topical surface, comprising: applying a chemical compound to at least a portion of an animal topical surface, the chemical compound comprising a bridged polycyclic compound having a structure (Ib): wherein Z comprises at least one bridge, wherein at least one of the bridges is —R 2 —N + R 3 2 —R 4 —N + R 3 2 —R 2 —, —R 2 —NR 3 —R 4 —N + R 3 2 —R 2 —, or —R 2 —NR 3 —R 4 —NR 3 —R 2 —, and wherein each bridge independently couples R 1 to R 1 ; wherein each bridge independently couples R 1 to R 1 ; wherein each R 1 is independently N, N + H, or N + R 3 ; wherein each R 2 is independently an alkyl group, a substituted alkyl group, or an alkene; wherein each R 3 is independently a pharmaceutically active agent, a hydrogen, an ester, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocycle group, a substituted heterocycle group, an alkene, an ether, a guanidine derivative, a polyethyleneglycol, a polyethyleneimine, or any combination of these, and wherein at least two R 3 s are a pharmaceutically active agent comprising a guanidine or a guanidine derivative; wherein each R 4 is independently an aryl group or a substituted aryl group; wherein when R 4 is an aryl group the aryl group is a phenyl, a naphthyl, a biphenyl, a diphenylmethyl, or a benzophenone; and wherein when R 4 is a substituted aryl group the substituted aryl group is a phenyl having at least one substituent, a naphthyl having at least one substituent, a biphenyl having at least one substituent, a diphenylmethyl having at least one substituent, or a benzophenone having at least one substituent, wherein when R 4 is a substituted aryl group the substituted aryl group of R 4 has at least two substituents and each of two of the substituents of the substituted aryl group of R 4 are independently coupled to the adjacent nitrogen of the —NR 3 —R 2 moiety or the —N + R 3 2 —R 2 — moiety of the structure (Ib) or when R 4 is a substituted aryl group the substituted aryl group of R 4 has at least one substituent such that at least two moieties forming an aryl group of the substituted aryl group of R 4 are independently coupled to the adjacent nitrogen of the —NR 3 —R 2 — moiety or the —N + R 3 2 —R 2 — moiety of the structure (Ib); forming a coating over at least a portion of the animal topical surface; inhibiting or ameliorating at least one malady associated with an animal topical surface and/or tissue associated with an animal topical surface; and wherein at least one of the maladies is pyoderma, bacterial dermatitis, interdigital furunculosis, an infection, or a parasite.