Patent ID: 7371762

Claim:
A compound of formula 1 wherein R 1 represents hydrogen or lower alkyl, R 2 represents hydrogen; aryl; aryl-lower alkyl; heteroaryl; or heteroaryl-lower alkyl; wherein the aryl and heteroaryl residues may be mono-, di- or tri-substituted with lower alkyl, hydroxy, lower alkoxy, halogen, trifluoromethyl, amino, lower alkylamino, or lower alkylendioxy, and which substituents may be the same or different, R 3 represents one of the groups: —(CH 2 ) m —O—(CH 2 )n-Ar 1 ; —(CH 2 ) m —NH—(CH 2 ) n —Ar 1 ; —(CH 2 ) m —S—(CH 2 ) n —Ar 1 ; —(CH═CH)—(CH 2 ) n —Ar 1 ; —CHOH—(CH 2 ) n —Ar 1 ; —(CH 2 ) n —Ar 2 ; —CH 2 —Ar 2′ ; —(CH 2 )n-Ar 3 ; and —(CH 2 ) n —Ar 4 , wherein m represents the number 1, 2 or 3; n represents the number 0, 1, 2 or 3; and in case Ar 2 is present, n has the meaning 0, 2 or 3; Ar 1 represents hydrogen; an aryl or heteroaryl group, which group may be unsubstituted or mono-, di-, or trisubstituted with a substituent independently selected from the group D, wherein D represents hydroxy, lower alkyl, lower alkoxy, lower alkylendioxy, aryl, aryloxy, lower alkyl-sulfanyl, arylsulfanyl, halogen, amino, lower alkylamino, lower di-alkylamino, or trifluoromethyl; Ar 2 represents an aryl or heteroaryl group, which group is di-, or trisubstituted with a substituent selected from the group D, wherein D is as defined above; Ar 2′ represents an aryl or heteroaryl group, which group is di-, or trisubstituted with, lower alkyl, lower alkylendioxy, aryl, aryloxy, lower alkyl-sulfanyl, arylsulfanyl, halogen, amino, lower alkylamino, lower di-alkylamino, or trifluoromethyl; Ar 3 represents an aryl or heteroaryl group, which group is monosubstituted with aryl, aryloxy, arylsulfanyl, lower alkyl-sulfanyl, trifluoromethyl, or lower alkylendioxy; Ar 4 represents an aryl or heteroaryl group, which group is monosubstituted with Ar 1 with the proviso that Ar 1 does not represent hydrogen, or a pure enantiomer, a mixture of enantiomers, a pure diastereomer, a mixture of diastereomers, diastereomeric racemates and stereoisomers, or a pharmaceutically acceptable salt thereof.