Patent ID: 7714119

Claim:
An adeno-associated virus (AAV) vector for expression of a recombinant immunoglobulin or a fragment thereof, comprising: in the 5′ to 3′ direction, a promoter operably linked to all of (1) a coding sequence for the heavy chain of the immunoglobulin or the fragment thereof, (2) a coding sequence for a furin cleavage site, wherein the coding sequence for the furin cleavage site encodes an oligopeptide selected from the group consisting of SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, and SEQ ID NO:18, and wherein each of the amino acids encoded in the coding sequence for the furin cleavage site is cleavable by a carboxypeptidase, (3) a coding sequence for a 2A self-processing cleavage site and (4) a coding sequence for the light chain of an immunoglobulin or the fragment thereof, wherein the recombinant immunoglobulin or the fragment thereof binds an antigen.