Patent ID: 7501412

Claim:
An isoquinoline compound represented by the following formula (I) wherein R 1 is a hydrogen atom, a halogen atom, alkyl, alkoxy, haloalkyl, a hydroxyl group, amino, alkylamino, dialkylamino, nitro, cyano, acyl, carboxyl, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, acylamino, diacylamino, thiol, alkylthio, alkoxycarbonylamino, sulfamoyl, N-alkylsulfamoyl, N,N-dialkylsulfamoyl or alkoxyalkyloxy; R 2 is a hydrogen atom, alkyl or amino; D is void, —C(O)—(CH 2 ) n — wherein n is an integer of 0 to 7, or straight chain or branched chain alkylene having 1 to 8 carbon atoms, provided that when D is methylene, then R 2 is alkyl and when D is void, then R 2 is a hydrogen atom; and R 3 is amino, monoalkylamino, dialkylamino, or a group selected from the following formulas (a), (b), (c) and (d), provided that when D is void, then R 3 is (a) or (d) and when n is 0, then R 3 is (a), wherein m is an integer of 1 to 3, l is an integer of 1 to 3, R 4 is void, a hydrogen atom, alkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, alkylsulfonyl, acyl, acylamino, aryl optionally having substituent(s), heteroaryl optionally having substituent(s), arylalkyl optionally having substituent(s), heteroarylalkyl optionally having substituent(s), sulfamoyl or alkylsulfonylamino, R 5 is a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl or ketone, and M is —CH—, —C═C—, a nitrogen atom, an oxygen atom or a sulfur atom; an optically active form thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, a water adduct thereof or a solvate thereof.