Patent ID: 8802145

Claim:
A method of manufacture of a fast-disintegrating solid dosage form comprising steps (a)-(d), wherein: step (a) comprises dosing a mixed solid powder comprising one or more structure building components into cavities of blister packs or moulds, step (b) consists of dissolving a binder, and optionally a remaining component selected from the group consisting of an excipient, a solubilizer, a salt, a buffer, a wetting agent and an active ingredient, in water to form an aqueous solution, and then dosing the aqueous solution into the cavities with the powder to form a moistened, plasticized mass, wherein the amount of water in the aqueous solution is from 20% to 70% (w/w) of the total weight of all of the components of the fast-disintegrating solid dosage form, step (c) comprises freezing to below −20° C., and step (d) comprises subliming frozen water under high vacuum.