Patent ID: 7087593

Claim:
A compound of Formula I or a pharmaceutically acceptable salt or prodrug thereof, wherein X is selected from the group consisting of C, O, N and S Z is selected from the group consisting of CH and N Y is selected from the group consisting of ═O, ═N and ═S or tautomers thereof; SPU is a spacer unit providing a distance d between Z and N wherein —SPU— is a biradical selected from the group consisting of —(CR 6 R 7 ) n —A— and —C 3-8 -cycloalkyl- wherein n is in the range 1 to 5, such as 1, 2, 3, 4, or 5 and A is absent or an optionally substituted —C 3-8 -cycloalkyl; N together with R 1 and R 2 form a heterocyclic ring wherein said heterocyclic ring is 8-azabicyclo[3.2.1]octane and wherein the heterocyclic ring is substituted with one or more substituents R 4 selected from the group consisting of halogen, C 1-8 -alkyl, C 3-8 -cycloalkyl, C 1-8 -alkoxy, C 1-8 -alkylcarbonyl, C 1-8 -alkylidene, C 2-8 -alkenyl, C 2-8 -alkynyl, C 1-6 -alkyloxyimino, and C 1-6 -alkyloxyamino each of which may be optionally substituted with a substituent R 5 and wherein at least one of said substituents R 4 is R 4 ′ selected from the group consisting of C 1-8 -alkyl, C 3-8 -cycloalkyl, C 1-8 -alkoxy, C 1-8 -alkylcarbonyl, C 1-8 -alkylidene, each of which may be optionally substituted with a substituent R 5 ; R 5 is selected from the group consisting of hydrogen, halogen, hydroxy, C 1-8 -alkyl, C 1-8 -alkoxy, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 1-8 -alkylcarbonyl, C 1-8 -alkylidene, C 2-8 -alkenyl and C 2-8 -alkynyl; R X may be absent or selected from the group consisting of hydrogen, optionally substituted C 1-8 -alkyl, optionally substituted C 3-8 -cycloalkyl, optionally substituted C 2-8 -alkenyl, optionally substituted C 2-8 -alkynyl, CH 2 —N(R 5 )(R 5 ), CH 2 —OR 5 , CH 2 —SR 5 , CH 2 —O—C(═O)R 5 , CH 2 —O—C(═S)R 5 ; R 3 may be present 0–4 times and selected from the group consisting of halogen, hydroxy, optionally substituted C 1-8 -alkyl, C 1-8 -alkoxy, optionally substituted C 1-8 -alkylidene, optionally substituted C 2-8 -alkenyl, optionally substituted C 2-8 -alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3-8 -cycloalkyl, optionally substituted C 3-8 -heterocyclyl, and optionally substituted C 1-8 -alkylcarbonyl; each R 6 and each R 7 is optionally and independently selected from the group consisting of hydrogen, halogen, hydroxy, optionally substituted C 1-8 -alkyl, C 1-8 -alkoxy, optionally substituted C 1-8 -alkylidene, optionally substituted C 2-8 -alkenyl, optionally substituted C 2-8 -alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3-8 -cycloalkyl, optionally substituted C 3-8 -heterocyclyl, and optionally substituted C 1-8 -alkylcarbonyl.