Patent ID: 8920775

Claim:
A method for preparing nanoparticle compositions loaded with radionuclides comprising: a. providing a nanoparticle composition comprising a vesicle forming component and an agent-entrapping component enclosed by said vesicle forming component; b. providing a component for transporting the radionuclides over the vesicle membranes, said component being an ionophore selected from the group consisting of quinoline derivatives of formula A, a stereoisomer thereof or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein X represents hydroxy (OH), amino (NH 2 ) or sulphydryl (SH) and wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 independently of each other, represent substituents selected from the group consisting of hydrogen (H), halo (Cl, Br, I), methyl (CH 3 ), ethyl (C 2 H 5 ), propyl (C 3 H 8 ), butyl (C 4 H 11 ), amino (NH 2 ), dimethylamino (N(CH 3 ) 2 ), hydroxy (OH), cyano (CN), sulphydryl (SH), carboxy (COOH), β-D-galactopyranoside (C 6 O 6 H 11 ), glucoronide (C 6 H 9 O 7 ), sulphonyl (SO 3 H), benzyl (C 6 H 4 COOH), and benzyl (C 6 H 5 (CH 2 )), and wherein R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , R 4 and R 5 , or R 5 and R 6 —together with the aromatic ring to which they are attached—may form a benzo-fused carbocyclic aromatic ring or an aliphatic ring; and c. entrapping the radionuclides within the interior of the nanoparticle composition.