Patent ID: 8088892

Claim:
An isolated polypeptide specifically inhibiting TrioGEFD2 domain, selected from the group consisting of: (i) an isolated polypeptide consisting of the amino acid sequence SEQ ID NO: 4, wherein amino acid residues at positions 10, 11, 12, 28, 29 and 31 are essential residues for inhibition of TrioGEFD2 activity, and amino acid residues at positions 1-9, 13, 16, 23-24, and 32-42 are non essential residues for inhibition of TrioGEFD2 activity; and (ii) an isolated polypeptide consisting of a sequence selected from the group consisting of SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16 and SEQ ID NO: 18, wherein said polypeptide inhibits TrioGEFD2 domain, and wherein said polypeptide does not inhibit TrioGEFD1 domain.