Patent ID: 8128935

Claim:
An isolated polypeptide which is (a) a polypeptide which consists of the polypeptide sequence set forth in SEQ ID NO: 2, SEQ ID NO: 4 or SEQ ID NO: 6, (b) a polypeptide consisting of the polypeptide sequence which is encoded by the polynucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5, or (c) a polypeptide variant consisting of the polypeptide sequence set forth in SEQ ID NO: 2 with the amino acid variations set forth in clones 1 to 11, wherein (1) clone 1 consists of L54, I57, V62, S76, T100, N107, Y137, P141, T142, K189, Q219, K221, L227, I231, S235, T237, V238, K248, A258, I264, K270, K282, L287, P299, A321, L322, S332, Q346, P347, T351, L357, N358, V362, S384, A410, D419, Y456, A457, K460, and E472; (2) clone 2 consists of L54, I57, V62, T76, T100, N107, Y137, P141, T142, K189, Q219, K221, I231, S235, T237, V238, K248, A258, I264, K270, K282, L287, P299, A321, L322, S332, Q346, P347, T351, L357, N358, V362, S384, A410, D419, Y456, A457, K460, and E472; (3) clone 3 consists of P141, K282, L287, P299, L347, and E351; (4) clone 4 consists of G289, A410, D419, Y456, A457, K460, and E472; (5) clone 5 consists of L347, E351, S384, A410, D419, Y456, A457, K460, and E472; (6) clone 6 consists of N107, Y137, P141, T142, K189, Q219, K221, I231, S235, T237, V238, K248, A258, I264, K270, K282, L287, P299, A321, L322, S332, Q346, P347, T351, L357, N358, V362, S384, A410, D419, Y456, A457, and K460; (7) clone 7 consists of K248, A258, I264, K270, K282, L287, P299, A321, L322, S332, Q346, P347, T351, L357, N358, V362, and S384; (8) clone 8 consists of Q219, K221, I231, S235, T237, V238, K248, A258, I264, K270, K282, L287, P299, and E351; (9) clone 9 consists of M231, T246, A251, C263, G289, L307, L309, and E334; (10) clone 10 consists of Q219, K221, I231, S235, T237, M238, V242, V246, K248, A258, I264, K270, K282, L287, P299, A321, L322, S332, Q346, P347, T351, N358, V362, S384, insertion of GA between positions 407 and 408, N452, Y456, A457, K460, and E472; (11) clone 11 consists of insertion of GA between positions 407 and 408.