Patent ID: 6958358

Claim:
A compound according to general formula (I): wherein: R 1 =C 0-7 -alkyl (when C=0, R 1 is simply hydrogen), C 3-6 -cycloalkyl or Ar—C 0-7 -alkyl (when C=0, R 1 is simply an aromatic moiety Ar); Ar is an aromatic moiety which is a 5- or 6-membered monocyclic or 9- or 10-membered bicyclic ring, wherein the aromatic ring is optionally substituted; Z=O or S; Y=CR 5 R 6 —CO, where R 5 and R 6 are independently chosen from C 0-7 -alkyl, C 3-6 -cycloalkyl or Ar—C 0-7 -alkyl; (X) o =CR 7 R 8 , where R 7 and R 8 are independently chosen from C 0-7 -alkyl, C 3-6 -cycloalkyl and Ar—C 0-7 -alkyl and o is a number from zero to three; (W) n =O, S, C(O), S(O) or S(O) 2 or NR 9 , where R 9 is chosen from C 0-7 -alkyl, C 3-6 -cycloalkyl and Ar—C 0-7 -alkyl and n is zero or one; (V) m =C(O), C(S), S(O), S(O) 2 , S(O) 2 NH, OC(O), NHC(O), NHS(O), NHS(O) 2 , OC(O)NH, C(O)NH or CR 10 OR 11 , where R 10 and R 11 are independently chosen from C 0-7 -alkyl, C 3-6 -cycloalkyl, Ar—C 0-7 -alkyl and m is a number from zero to three, provided that when m is greater than one, (V) m contains a maximum of one carbonyl or sulphonyl group; U=a stable 5- to 7-membered monocyclic or a stable 8- to 11-membered bicyclic ring which is either saturated or unsaturated and which includes zero to four heteroatoms (as detailed below), said ring selected from: wherein R 12 is: C 0-7 -alkyl, C 3-6 -cycloalkyl, Ar—C 0-7 -alkyl, O—C 0-7 -alkyl, O—C 3-6 -cycloalkyl, O—Ar—C 0-7 -alkyl, S—C 0-7 -alkyl, S—C 3-6 -cycloalkyl, S—Ar—C 0-7 -alkyl, NH—C 0-7 -alkyl, NH—C 3-6 -cycloalkyl, NH—Ar—C 0-7 -alkyl, N(C 0-7 -alkyl) 2 , N(C 3-6 -cycloalkyl) 2 or N(Ar—C 0-7 -alkyl) 2 or, when it is part of the group CHR 12 or CR 12 , R 12 may be halogen; A is chosen from: CH 2 , CHR 12 , O, S and NR 13 ; wherein R 12 is as defined above and R 13 is chosen from: C 0-7 -alkyl, C 3-6 -cycloalkyl and Ar—C 0-7 -alkyl; B, D and G are independently chosen from: CR 12 , where R 12 is as defined above, or N; E is chosen from: CH 2 , CHR 12 , O, S and NR 13 , where R 12 and R 13 are defined as above; J, L, M, R, T, T 2 , T 3 and T 4 are independently chosen from: CR 12 and N, where R 12 is as defined above; T 5 is chosen from: CH or N; q is a number from one to three, thereby defining a 5-, 6- or 7-membered ring.