Patent ID: 7262302

Claim:
A compound of the formula I wherein X is CH 2 , O, S, S(=O), S(=O) 2 , or NR a , wherein R a is hydrogen or a protecting group; Y and Z are each independently hydrogen, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, halo-C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, trifluoromethoxy, C 1 -C 4 alkanoyl, amino, amino-C 1 -C 4 alkyl, N-(C 1 -C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, thiol, C 1 -C 4 alkylthio, sulfonyl, C 1 -C 4 alkylsulfonyl, sulfinyl, C 1 -C 4 alkylsulfinyl, carboxy, C 1 -C 4 alkoxycarbonyl, cyano, or nitro; R 1 is hydrogen, halogen, an optionally substituted C 1 -C 7 alkyl or C 2 -C 7 alkenyl, C 2 -C 7 alkynyl, an optionally substituted aryl, heteroaryl or heterocycle, C 1 -C 2 alcohol, hydroxy, hydroxy-C 2 -C 7 alkenyl, hydroxy-C 2 -C 7 alkynyl, C 1 -C 7 alkoxy, thiol, thio-C 2 -C 7 alkenyl, thio-C 2 -C 7 alkynyl, C 1 -C 7 alkylthio, amino-C 2 -C 7 alkenyl, amino-C 2 -C 7 alkynyl, amino-C 1 -C 7 alkoxy, C 1 -C 7 alkanoyl, aroyl, oxo-C 1 -C 7 alkyl, C 1 -C 7 alkanoyloxy, carboxy, an optionally substituted C 1 -C 7 alkyloxycarbonyl or C 1 -C 7 aryloxycarbonyl, carbamoyl, N-(C 1 -C 7 -alkyl)carbamoyl, N,N-di(C 1 -C 7 -alkyl)carbamoyl, cyano, cyano-C 1 -C 7 alkyl, sulfonyl, C 1 -C 7 alkylsutfonyl, sulfinyl, C 1 -C 7 alkylsulfinyl, nitro, or a substituent of the formula II wherein R 2 and R 3 are each independently hydrogen, C 1 -C 4 alkyl, or aryl or R 2 and R 3 taken together with the nitrogen atom to which they are attached form an optionally substituted heterocycle or heteroaryl; m is an integer from 1 to 3; n is an integer from 0 to 3; Q 1 and Q 2 are each independently oxygen, sulfur, wherein y 1 and y 2 are each independently hydrogen, halogen, an optionally substituted C 1 -C 4 alkyl or aryl, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkanoyl, thiol, C 1 -C 4 alkylthio, sulfonyl, C 1 -C 4 alkylsulfonyl, sulfinyl, C 1 -C 4 alkylsulfinyl, cyano, or nitro or y 1 and y 2 taken together with the carbon atom to which they are attached form a carbonyl or imino group; and pharmacologically acceptable salts and solvates thereof.