Patent ID: 7601695

Claim:
A compound according to Formula 1 or Formula 2, or pharmaceutically acceptable salts, hydrates, solvates, esters or prodrugs thereof wherein: R 1 is selected from the group consisting of H, cyclic and acyclic alkyl, cyclic and acyclic alkyl-hydroxyamine, aryl, aryl-hydroxyamine, cyclic and acyclic acyl, cyclic and acyclic acyl-hydroxyamine, heteroalkyl, heteroalkyl-hydroxyamine, heteroaryl, heteroaryl-hydroxyamine, acylaryl, acylaryl-hydroxyamine, acylheteroaryl, acylheteroaryl-hydroxyamine, alkylaryl, alkylaryl-hydroxyamine, alkylheteroaryl, alkylheteroaryl-hydroxyamine, sulfonylalkyl, sulfonylalkyl-hydroxyamine, acylalkoxylsulfonylalkyl, and acylalkoxylsulfonylalkyl-hydroxyamine; or R 1 is —C(O)—NR 4 R 5 , where R 4 and R 5 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureido, and carbamoyl; or R 1 is a monosaccharide, a disaccharide or a trisaccharide, providing that R 1 is not desosamine or an oxidized, reduced or substituted desosamine; R 2 and R 3 are each OH, or R 2 and R 3 are taken together with the attached carbons to form a heterocycle of the formula: where Z is O, or —N(R 6 ); where R 6 is hydrogen, hydroxy, alkyl, alkoxy, heteroalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, dimethylaminoalkyl, acyl, or sulfonyl; X is H; and Y is OR 7 ; where R 7 is a monosaccharide or disaccharide, alkyl, aryl, heteroaryl, acyl-, or —C(O)—NR 8 R 9 , where R 8 and R 9 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, heteroalkyl, aryl, heteroaryl, alkoxy, dimethylaminoalkyl, acyl, sulfonyl, ureido, and carbamoyl; or X and Y are taken together with the attached carbon to form carbonyl; V is —C(O)—, —C(═NR 11 )—, —CH(NR 12 , R 13 )—, or —N(R 14 )CH 2 —, where N(R 14 ) is attached to the C-10 carbon of the compounds of Formulae 1 and 2; wherein R 11 is hydroxy or alkoxy, R 12 and R 13 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureido, and carbamoyl; R 14 is hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureido, or carbamoyl; W is H, F, Cl, Br, I, or OH; A is —CH 2 —, —C(O)—, —C(O)O—, —C(O)NH—, —S(O) 2 —, —S(O) 2 NH—, or —C(O)NHS(O) 2 —; B is —(CH 2 ) n — where n is an integer ranging from 0-10, or B is an unsaturated carbon chain of 2-10 carbons; C is hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, aminoaryl, alkylaminoaryl, acyl, acyloxy, sulfonyl, ureido, or carbamoyl; and R 10 is hydrogen or acyl.