Patent ID: 7622461

Claim:
A method of treating cognitive impairment associated with Alzheimer's disease, schizophrenia or related idiopathic psychoses, Huntington's disease, Tourette's syndrome, anxiety, affective disorders, drug-induced psychoses, psychoses secondary to neurodegenerative disorders, major depression, bipolar disorder, depression with psychotic features, or sleep disorders, comprising administering to a subject exhibiting one or more symptoms of cognitive impairment a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: A has the structure: wherein each bond represented by a dashed and solid line in A represents a carbon-carbon single bond; X is nitrogen; X′ is C; Y is nitrogen; W is nitrogen; each n is 1; R 1 is hydrogen; L is absent; a, b, c, and d are each carbon, e, f, g, and h are each carbon, R 2 , R 3 , R 4 , and R 5 , are each separately selected from the group consisting of hydrogen, halogen, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 -alkoxyalkyl, optionally substituted C 1-6 alkylthio, perhaloalkyl, CN, COR 10 , CONHR 10 , NHCONHR 10 , SO 2 NHR 10 , SO 2 R 10 , OSO 2 R 10 , NO 2 , NHCOR 10 , or R 2 and R 3 , or R 3 and R 4 , or R 4 and R 5 taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety; R 6 , R 7 , R 8 , and R 9 , are each separately selected from the group consisting of hydrogen, halogen, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkyloxy, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 -alkoxyalkyl, optionally substituted C 1-6 alkylthio, perhaloalkyl, CN, COR 10 , CONHR 10 , NHCONHR 10 , SO 2 NHR 10 , SO 2 R 10 , OSO 2 R 10 , NO 2 , NHCOR 10 , or R 6 and R 7 , or R 7 and R 8 , or R 8 and R 9 taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety; Z is oxygen; R 10 is selected from the group consisting of hydrogen, optionally substituted C 1-6 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl optionally substituted aryl, optionally substituted arylalkyl, and perhaloalkyl; and each bond represented by a dashed and solid line in Formula I represents a carbon-carbon double bond.