Patent ID: 7655686

Claim:
A compound of the formula wherein R 1 is hydrogen or (C 1-4 )alkyl, R 2 is optionally substituted (C 1-8 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, aryl or heteroaryl, R 3 is —CH(R e )C(═O)N(R a )R b or —(CH 2 ) k N(R c )R d , wherein k is 0, 1 or 2, R a , R b , R c and R d , independently, are hydrogen or an optionally substituted (C 1-8 )alkyl, (C 5-9 )bicycloalkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, aryl, aryl(C 1-4 )alkyl, heteroaryl, heteroaryl(C 1-4 )alkyl, 4-chromanyl, 1,2,3,4-tetrahydro-quinolin-4-yl, 1,2,3,4-tetrahydro-naphthalen-1-yl, thiochroman-4-yl-1,1-dioxide, 4-isochromanyl, 1,2,3,4-tetrahydro-isoquinolin-4-yl, thioisochroman-4-yl-1,1-dioxide, 1,1-dioxo-1,2,3,4-tetrahydro-1 lambda*6*-benzo[e][1,2]thiazin-4-yl, 1,1-dioxo-3,4-dihydro-1H-1lambda*6*-benzo[c][1,2]oxathiin-4-yl, 2,2-dioxo-1,2,3,4-tetrahydro-2lambda*6*-benzo[c][1,2]thiazin-4-yl or 2,2-dioxo-3,4-dihydro-2H-2lambda*6*-benzo[e][1,2]oxa-thiin-4-yl group, or R a and R b , or R c and R d , together with the nitrogen to which they are attached, form an optionally substituted pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl group, and R e is (C 1-8 )alkyl, (C 1-4 )alkoxy(C 1-4 )alkyl, (C 3-7 )cycloalkyl or (C 3-7 )cycloalkyl(C 1-4 )alkyl, R 4 is hydrogen or an optionally substituted (C 1-8 )alkyl, (C 1-4 )alkoxy(C 1-4 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, (C 2-6 )alkenyl, (C 2-6 )alkynyl, (C 3-7 )cycloalkoxy(C 1-4 )alkyl or aryl group, R 5 is hydrogen or optionally substituted (C 1-4 )alkyl, R 6 is hydrogen, hydroxy or halogen, and m and p, independently, are 1 or 2, in free base form or in acid addition salt form.