Patent ID: 8188121

Claim:
An aza teraryl compound of Formula (III): wherein: p and q are each independently an integer 0, 1, 2, 3, 4, 5, 6, 7, or 8; A 1 , Y 1 , and Z 1 are selected from the group consisting of N and CR 7 , wherein R 7 is selected from the group consisting of H, hydroxy, halo, nitro, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, and aryloxy, wherein one of A 1 , Y 1 , and Z 1 is N; R 6 is selected from the group consisting of H, hydroxy, halo, nitro, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, and aryloxy; Ar 1 is: wherein m is an integer 0, 1, 2, 3, or 4; and each R 1 is independently selected from the group consisting of H, hydroxy, halo, nitro, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, and aryloxy; Ar 3 is: wherein: A, D, E, G, Y, and Z are independently selected from the group consisting of N and CR 4 , wherein R 4 is selected from the group consisting of H, hydroxy, halo, nitro, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, and aryloxy, wherein at least one of A, D, E, G, Y, and Z is nitrogen; R 2 and R 21 are selected from the group consisting of H, hydroxy, halo, nitro, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, and aryloxy; and L 1 and L 2 are independently selected from the group consisting of: wherein: R 11 , R 12 , R 13 , R 14 , R 15 , and R 20 are each independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, aralkyl, hydroxy, alkoxy, hydroxyalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aminoalkyl, acyloxyl, alkylaminoalkyl, and alkoxycarbonyl; or R 11 and R 12 together represent a C 2 to C 10 alkyl, C 2 to C 10 hydroxyalkyl, or a C 2 to C 10 alkylene; or R 11 and R 12 together are: wherein u is an integer 1, 2, 3, or 4; and R 16 is H or —CONHR 17 NR 18 R 19 , wherein R 17 is alkyl, and R 18 and R 19 are each independently selected from the group consisting of H and alkyl; wherein substituted alkyl is alkyl substituted by one or more of the group consisting of alkyl, aryl, halo, arylamino, acyl, hydroxy, aryloxy, alkoxy, alkylthio, arylthio, aralkyloxy, aralkylthio, carboxyl, alkoxycarbonyl, cycloalkyl, nitro, amino, alkylamino, dialkylamino, sulfate, and mercapto; and substituted aryl is aryl substituted by one or more of the group consisting of alkyl, aryl, aralkyl, hydroxy, alkoxy, aryloxy, aralkyloxy, carboxyl, acyl, halo, nitro, alkoxycarbonyl, aryloxycarbonyl, aralkylcarbonyl, acyloxyl, acylamino, aroylamino, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylthio, alkylthio, amino, alkylamino, dialkylamino, arylamino, diarylamino, sulfate, and mercapto; or a pharmaceutically acceptable salt thereof.