Patent ID: 7538140

Claim:
An ester compound represented by the formula (1′) wherein R 2′ and R 2″ are each independently hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, halogen, halo C 1 -C 6 alkyl, C 1 -C 6 acyl, C 2 -C 6 alkenyl, or cyano; X 1 is —O— or —NR 10 — wherein R 10 is hydrogen, C 1 -C 6 alkyl, or C 3 -C 7 cycloalkyl; R 1 is hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkyl, halo C 1 -C 6 alkyloxy, optionally substituted C 6 -C 14 aryl, optionally substituted C 7 -C 16 aralkyl, optionally substituted C 6 -C 14 aryloxy, optionally substituted C 7 -C 16 aralkyloxy, optionally substituted C 7 -C 15 arylcarbonyl, C 2 -C 7 alkoxycarbonyl, halogen, C 2 -C 6 alkenyl, —N(R 40 )(R 41 ) wherein R 40 and R 41 are each independently hydrogen or optionally substituted C 6 -C 14 aryl, R 3 and R 4 are each independently hydrogen, hydroxy, halogen, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkyl, C 7 -C 16 aralkyloxy, C 1 -C 6 acyl, CON(R 11 )(R 12 ) (wherein R 11 and R 12 are each independently hydrogen, C 1 -C 6 alkyl, optionally substituted C 6 -C 14 aryl, optionally substituted C 7 -C 16 aralkyl, or C 1 -C 6 alkoxy), —(CH 2 ) g —N(R 13 )(R 14 ) (wherein R 13 and R 14 are each independently hydrogen, C 1 -C 6 alkyl, C 2 -C 7 alkoxycarbonyl, or C 1 -C 6 acyl, and q is an integer of 0 to 3), or —CO(R 15 ) (wherein R 15 is hydroxy, C 1 -C 6 alkoxy, optionally substituted C 6 -C 14 aryloxy, optionally substituted C 7 -C 16 aralkyloxy or C 1 -C 6 alkyl); l is an integer of 0 to 3; m is an integer of 0 to 3; R 5 , R 6 , and R 7 are each independently hydrogen C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 7 alkoxycarbonyl, carboxyl, halogen, cyano, nitro, halo C 1 -C 6 alkyl, C 1 -C 6 acyl, hydroxy, amino, optionally substituted C 6 -C 14 aryl, or —(CH 2 ) r —CON(R 16 )(R 17 ) (wherein R 16 and R 17 are each independently hydrogen, C 1 -C 6 alkyl, or halo C 1 -C 6 alkyl and r is an integer of 0 to 3); ring C is C 6 -C 14 aryl, C 7 -C 15 arylcarbonylamino, C 8 -C 17 aralkylcarbonylamino, C 3 -C 7 cycloalkyl, or C 7 -C 16 aralkyl, or ring C may be taken together with R 7 and R 8 to form R 8 and R 9 are each independently hydrogen, C 1 -C 6 alkyl, optionally substituted C 6 -C 14 aryl, hydroxy C 1 -C 6 alkyl, —CON(R 18 )(R 19 ) (wherein R 18 and R 19 are each independently hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, halo C 1 -C 6 alkyl, C 2 -C 12 alkoxyalkyl, or optionally substituted C 6 -C 14 aryl), —COO(R 20 ), or —(CH 2 ) s —OCO(R 20 ) (wherein R 20 is hydrogen, C 1 -C 6 alkyl, or C 3 -C 7 cycloalkyl, s is an integer of 0 to 3), —N(R 21 )(R 22 ) (wherein R 21 and R 22 are each independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 acyl, or C 1 -C 6 alkylsulfonyl), or R 8 and R 9 may be taken together to form C 3 -C 7 cycloalkyl, or a pharmaceutically acceptable salt thereof.