Patent ID: 8314094

Claim:
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 represents optionally halogenated C 1-6 alkyl or optionally halogenated C 3-8 cycloalkyl; R 2 represents a substituent selected from a group consisting of the following groups: wherein W represents C 1-6 alkylene, C 2-6 alkenylene, C 2-6 alkynylene or C 3-6 cycloalkylene, wherein the alkylene, alkenylene, alkynylene or cycloalkylene may be substituted by optionally halogenated C 1-3 alkyl, optionally halogenated C 1-3 alkyloxy, hydroxyl or halogen; R represents C 1-6 alkyl, C 3-8 cycloalkyl, aryl or heteroaryl, wherein the C 1-6 alkyl, C 3-8 cycloalkyl, aryl or heteroaryl may be substituted by halogen, optionally halogenated C 1-6 alkyl, optionally halogenated C 1-6 alkyloxy, C 1-6 alkylsulfonyl, cyano, phenyl, C 1-6 alkylthio, hydroxyl, amino, C 1-6 alkylamino, di-C 1-6 alkylamino, hydroxy-C 1-6 alkyl, amino-C 1-6 alkyl, C 1-6 alkylamino-C 1-6 alkyl, di-C 1-6 alkylaminoalkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylcarbamoyl, C 3-8 cycloalkylcarbamoyl, C 1-6 alkylsulfonylamino or C 1-6 alkylaminosulfonyl; R 3 represents a hydrogen atom, C 1-6 alkyl, aryl or heteroaryl; X represents —O—, —C(R 4a )(R 4b )— or —NR 5 —; R 4a , R 4b and R 5 each independently represent hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, aryl or heteroaryl, wherein the C 1-6 alkyl, C 3-8 cycloalkyl, aryl or heteroaryl may be substituted by halogen, optionally halogenated C 1-6 alkyl, optionally halogenated C 1-6 alkyloxy, C 1-6 alkylsulfonyl, cyano, aryl or heteroaryl; Y 1 represents —CR 6 — or —N—; Y 2 represents —CR 7 — or —N—; Y 3 represents —CR 8 — or —N—; Y 4 represents —CR 9 — or —N—; R 6 , R 7 , R 8 and R 9 each independently represent a hydrogen atom, halogen, cyano, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, hydroxyl, hydroxy-C 1-6 alkyl, amino, C 1-6 alkylamino, di-C 1-6 alkylamino, amino-C 1-6 alkyl, C 1-6 alkylamino-C 1-6 alkyl, di-C 1-6 alkylamino-(C 1-6 )alkyl, C 1-6 alkoxy-C 1-6 alkyl, heterocyclyl, aryl, heteroaryl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfinyl, C 1-6 alkylthio, arylsulfonyl, heteroarylsulfonyl, arylsulfinyl, heteroarylsulfinyl, arylthio, heteroarylthio, C 1-6 alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, C 1-6 alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, C 1-6 alkylcarbamoyl, C 3-8 cycloalkylcarbamoyl, heterocyclylcarbamoyl, arylcarbamoyl, heteroarylcarbamoyl, C 1-6 alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, C 1-6 alkylsulfamoyl, arylsulfamoyl or heteroarylsulfamoyl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl may be substituted by a group selected from the group consisting of halogen, optionally halogenated C 1-6 alkyl, optionally halogenated C 1-6 alkyloxy, C 1-6 alkylsulfonyl, carboxyl and cyano.