Patent ID: 7288558

Claim:
A method for treatment of a urinary disease characterized by contraction of the urethra and/or prostate or characterized by occlusion of lower urinary tract, wherein the urinary disease is one or more of dysuria and pollakiuria, comprising administering to a subject having said urinary disease an amount of a lysophosphatidic acid (LPA) receptor antagonist that is effective for relaxing the urethra and/or prostate, wherein the LPA receptor antagonist is a compound represented by formula (1), or a salt thereof: wherein R 1 is an optionally substituted alkyl, aryl, alkyloxy, aryloxy, alkylthio, or arylthio, or is a halogen atom, R 2 is an optionally substituted alkyl, aryl, alkyloxy, or aryloxy, or is a halogen atom, R 3 is a hydrogen atom, lower alkyl, or alkyl halide, R 4 is selected from the group consisting of: (a) an optionally substituted phenyl or aryl, (b) a substituted or unsubstituted alkyl, and (c) a substituted or unsubstituted alkenyl, X is an oxygen atom, and when R 3 is a hydrogen atom, R 4 represents a group other than methyl.