Patent ID: 8853395

Claim:
Process for the preparation of lurasidone hydrochloride of formula 1 comprising the following steps: a) reacting a compound of formula 4 and a compound of formula 5 in a solvent having a boiling point greater than 80° C. in the presence of an organic base having a pK B greater than 10, to yield a compound of formula 3 b) reacting the compound of formula 3 obtained in step a) with a compound of formula 2 in a solvent having a boiling point greater than 80° C. in the presence of an organic base having a pK B greater than 10, to yield lurasidone base; c) converting lurasidone base to an acid addition salt of lurasidone with an organic carboxylic acid having a pK A lower than 3; d) converting the acid addition salt of lurasidone obtained in step c) to lurasidone hydrochloride.