Patent ID: 8623625

Claim:
An isolated nucleic acid selected from the group consisting of (I), (II) and (III): (I) a cDNA encoding a polypeptide consisting of amino acids 37 to 346 of SEQ ID NO:2, or encoding a polypeptide consisting of an amino acid sequence at least 95% identical to the amino acid sequence of SEQ ID NO:2 and having an activity of transferring a sulfate group to a glycosaminoglycan which is a sulfate group acceptor; (II) a cDNA consisting of the nucleotide sequence of SEQ ID NO:1; and (III) an isolated DNA which hybridizes under stringent conditions to the cDNA according to (I) or (II) and which encodes a polypeptide having an activity of transferring a sulfate group to a glycosaminoglycan which is a sulfate group acceptor, or an isolated DNA fully complementary to the cDNA according to (I) or (II) wherein hybridization under the stringent conditions occurs at 42° C. in the presence of 50% formamide, 5×Denhardt's solution, 0.5% SDS (sodium dodecyl sulfate), 5×SSPE (sodium chloride/sodium phosphate/ethylenediaminetetraacetic acid) buffer and 100 μg/ml denatured salmon sperm DNA.