Patent ID: 8143314

Claim:
A topical pharmaceutical composition for the treatment of ineffective esophageal motility, suitable for spraying on the posterior pharynx, comprising: from about 15 millimolar to about 40 millimolar bethanechol or pharmaceutically acceptable salts thereof; about 500 millimolar of a combination of pharmaceutically acceptable bile acids, the combination consisting of: taurocholic acid, pharmaceutically acceptable salts thereof, or pharmaceutically acceptable metabolically related derivatives thereof; glycholic acid, pharmaceutically acceptable salts thereof, or pharmaceutically acceptable metabolically related derivatives thereof; taurochenodeoxycholic acid, pharmaceutically acceptable salts thereof, or pharmaceutically acceptable metabolically related derivatives thereof; taurodeoxycholic acid, pharmaceutically acceptable salts thereof, or pharmaceutically acceptable metabolically related derivatives thereof; glycochenodeoxycholic acid, pharmaceutically acceptable salts thereof, or pharmaceutically acceptable metabolically related derivatives thereof; glycodeoxycholic acid, pharmaceutically acceptable salts thereof, or pharmaceutically acceptable metabolically related derivatives thereof; and a pharmaceutically acceptable liquid carrier.