Patent ID: 8501797

Claim:
A compound having the structure I wherein HET-1 is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms: wherein Y can be N or CH, Z can be N or C, and wherein HET-1 may optionally be substituted with up to three R 7 , R 8 and R 9 substituents individually selected from hydrogen, C 1 - C 6 alkyl; halogen; cyano, halo(C 1 -C 6 )alkyl; aryl, alkoxy and C 1 -C 6 hydroxyalkyl, and wherein * denotes the attachment point, Q is phenyl, optionally substituted with one, two or three R 2 , R 3 , R 4 R 5 , and R 6 substituents, wherein R 2 , R 3 , R 4 , R 5 , and R 6 are each selected independently from H, C 1 -C 6 alkoxy and halogen: or a monocycle 5-membered or 6-membered heteroaromatie group containing 1 or 2 heteroatoms, -L- is a linker selected from —S—CH 2 —, —CH 2 —S—, —CH 2 -CH 2 —, —CH═CH—, and —C≡C—, R 1 is selected from H, C 1 -C 6 alkyl; C 1 -C 6 alkyl(C 3 -C 8 )cycloalkyl; C 1 -C 6 hydroxyalkyl, CH 2 CN, CH 2 , C(O)NH 2 , C 1 C 6 arylalkyl, and C 1 -C 6 alkyl-heterocycloalkyl, and pharmaceutically acceptable salts thereof, provided that the compound is not 2-(5-phenyl-1H-imidazol -2-ylmethylsulfanyl)-1H-benzoimidazole or 2-(5-phenyl-1H- imidazol-2-sulfanyl-methyl)-1H-benzoimidazole.