Patent ID: 8118877

Claim:
A biointerface membrane suitable for implantation in a soft tissue, the membrane comprising layers of: a first domain comprising an open cell configuration having a plurality of interconnected cavities and a solid portion, wherein the first domain has a depth of greater than one cavity in three dimensions substantially throughout an entirety of the first domain, and wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to redirect fibrous tissue contracture in vivo, thereby interfering with barrier cell layer formation within or around the first domain, and wherein a substantial number of the interconnected cavities are greater than or equal to about 90 microns in at least one dimension; and a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes; wherein the first and second domain layers are adhered together to form a unitary structure.