Patent ID: 7893102

Claim:
A method of treating myelodysplastic syndrome, complex regional pain syndrome, arthritis, rheumatoid arthritis, inflammatory bowel disease, sepsis, Crohn's disease, aphthous ulcer, cachexia, graft versus host disease, asthma, adult respiratory distress syndrome, acquired immune deficiency syndrome, inflammation of the lungs, depression, chronic obstructive pulmonary disorder, atopic dermatitis, psoriasis, multiple sclerosis, congestive heart failure, cardiomyopathy, pulmonary edema, endotoxin-mediated septic shock, acute viral myocarditis, cardiac allograft rejection or myocardial infarction in a mammal which comprises administering thereto a therapeutically effective amount of a compound having the formula (I): wherein: Y is —C(O)—, —CH 2 , —CH 2 C(O)—, —C(O)CH 2 —, or SO 2 , Z is —H, —C(O)R 3 , —(C 0-1 -alkyl)-SO 2 —(C 1-4 -alkyl), —C 1-8 -alkyl, —CH 2 OH, CH 2 (O)(C 1-8 -alkyl) or —CN; R 1 and R 2 are each independently —CHF 2 , —C 1-8 -alkyl, —C 3-18 -cycloalkyl, or —(C 1-10 -alkyl)(C 3-18 -cycloalkyl), and at least one of R 1 and R 2 is CHF 2 ; R 3 is —NR 4 R 5 , -alkyl, —OH, —O-alkyl, phenyl, benzyl, substituted phenyl, or substituted benzyl; R 4 and R 5 are each independently —H, —C 1-8 -alkyl, —OH, —OC(O)R 6 ; R 6 is —C 1-8 -alkyl, -amino(C 1-8 -alkyl), -phenyl, -benzyl, or -aryl; X 1 , X 2 , X 3 , and X 4 are each independent —H, -halogen, -nitro, —NH 2 , —CF 3 , —C 1-6 -alkyl, —(C 0-4 -alkyl)-(C 3-6 -cycloalkyl), (C 0-4 -alkyl)-NR 7 R 8 , (C 0-4 -alkyl)-N(H)C(O)—(R 8 ), (C 0-4 -alkyl)-N(H)C(O)N(R 7 R 8 ), (C 0-4 -alkyl)-N(H)C(O)O(R 7 R 8 ), (C 0-4 -alkyl)-OR 8 , (C 0-4 -alkyl)-imidazolyl, (C 0-4 -alkyl)-pyrrolyl, (C 0-4 -alkyl)-oxadiazolyl, or (C 0-4 -alkyl)-triazolyl triazolyl or X 1 and X 2 or X 2 and X 3 or X 3 and X 4 are taken together with the atoms that join them to form a cycloalkyl or heterocycloalkyl ring of 3, 4, 5, 6 or 7 atoms; and R 7 and R 8 are each independently H, C 1-9 -alkyl, (C 1-6 -alkyl)-(C 3-6 -cycloalkyl), (C 1-6 -alkyl)-N(R 7 R 8 ), (C 1-6 -alkyl)-OR 8 , phenyl, benzyl, or aryl; or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof.