Patent ID: 7759365

Claim:
A compound of formula 1: wherein R 1 is aryl, optionally substituted with one, two or three R 2 ; R 2 are each independently C 1-6 -alkyl, C 3-6 -cycloalkyl, C 1-6 -haloalkyl, C 6-10 -aralkyl, halogen, CN, COOR 3 , COR 3 , CONR 3 R 4 , NR 3 R 4 , NR 3 SO 2 R 4 , OR 3 , NO 2 , SR 3 , SOR 3 , SO 2 R 3 or SO 2 NR 3 R 4 ; R 3 is H, C 1-6 -alkyl, C 3-8 -cycloalkyl or (—C 3-8 -cycloalkyl)-C 1-6 -alkyl; R 4 is H, C 1-6 -alkyl, C 3-8 -cycloalkyl or (—C 3-8 -cycloalkyl)-C 1-6 -alkyl; R 5 is C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -acyloxy, C 6-10 -aralkyl, C 3-6 -cycloalkyl, (C 3-6 -cycloalkyl)-C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -thioalkyl, halogen, NO 2 , CN, or NR 3 R 4 ; R 6 are each independently C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -acyloxy, C 6-10 -aralkyl, C 3-6 -cycloalkyl, C 1-6 -haloalkyl, C 1-6 -thioalkyl, halogen, OR 3 , SR 3 , CN, NO 2 , COOR 3 , COR 3 , CONR 3 R 4 , NR 3 R 4 , NR 3 COR 4 , NR 3 SO 2 R 4 , SOR 3 , SO 2 R 3 , SO 2 NR 3 R 4 , aryl or het; R 7 is a substituent selected from the group consisting of aryl and het, both substituted with one, two, three or four substituents selected from the group consisting of COOR 7.1 , SO 2 R 7.1 , PO(OH) 2 , CONHCN, and SO 2 NHCOR 7.1 ; R 7.1 is H, C 1-6 -alkyl or aryl; R 8 is H, OH, C 1-6 -alkoxy, C 1-6 -haloalkyl, or halogen; R 9 is H, OH, C 1-6 -alkoxy, C 1-6 -haloalkyl, or halogen; A is straight, branched or cyclic C 2-8 -alkylene; optionally substituted with R 9 ; B is phenyl; D-E is —CH—CH 2 —, —C═CH—, — 8 —CH 2 —; Y is —CH 2 —, —NR 4 —, —O—, —S(O) n —; i, j are each independently 0, 1 or 2, wherein i+j=2; n is 0, 1 or 2; m is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, with the proviso that both R 7 and R 8 cannot be hydrogen at the same time.