Patent ID: 7671032

Claim:
A compound of formula VI: wherein A is C(═O)OR 1 , or C(═O)NHSO 2 R 2 , wherein; R 1 is hydrogen, or C 1 -C 6 alkyl; R 2 is C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl, C 0 -C 3 alkylheterocyclyl; wherein R 2 is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, oxo, nitrile, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl, C 0 -C 3 alkylheterocyclyl, NH 2 C(═O)—, Y—NRaRb, Y—O—Rb, Y—C(═O)Rb, Y—(C═O)NRaRb, Y—NRaC(═O)Rb, Y—NHSO p Rb, Y—S(═O) p Rb, Y—S(O)NRaRb, Y—C(═O)ORb and Y—NRaC(O)ORb; Y is independently a bond or C 1 -C 3 alkylene; Ra is independently H or C 1 -C 3 alkyl; Rb is independently H, C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl or C 0 -C 3 alkylheterocyclyl; p is independently 1 or 2; M is CR 7 R 7′ ; R 7′ taken together with R 7 forms a C 3 C 6 cycloalkyl ring substituted with J; q′ is 0 and k is 1; Rz is H, or together with the asterisked carbon forms an olefinic bond; Rq is H or C 1 -C 6 alkyl; W is —O— or —S—; R 8 is a ring system containing 1 or 2 saturated, partially saturated or unsaturated rings each of which has 4-7 ring atoms and each of which has 0 to 4 hetero atoms selected from S, O and N, the ring system being optionally spaced from W by a C 1 -C 3 alkyl group; any of which R8 groups can be optionally mono, di, or tri substituted with R 9 , wherein R 9 is independently selected from the group consisting of halo, oxo, nitrile, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl, C 0 -C 3 alkylheterocyclyl, NH 2 C(═O)—, Y—NRaRb, Y—O—Rb, Y—C(═O)Rb, Y—(C═O)NRaRb, Y—NRaC(O)Rb, Y—NHSO p Rb, Y—S(═O) p Rb, Y—S(═O) p NRaRb, Y—C(═O)ORb and Y—NRaC(O)ORb; wherein said carbocyclyl or heterocyclyl moiety is optionally substituted with R 10 ; wherein R 10 is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, amino, sulfonyl, (C 1 -C 3 alkyl)sulfonyl, NO 2 , OH, SH, halo, haloalkyl, carboxyl, amido; J is a single 3 to 10-membered saturated or partially unsaturated alkylene chain that extends from the R 7 /R 7′ cycloalkyl to G and forms a macrocycle, which chain is optionally interrupted by one to three heteroatoms independently selected from: —O—, —S— or —NR 12 —, and wherein 0 to 3 carbon atoms in the chain are optionally substituted with R 14 ; wherein; R 12 is H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or COR 13 ; R 13 is C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl, C 0 -C 3 alkylheterocyclyl; R 14 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, hydroxyl, halo, amino, oxo, thio, or C 1 -C 6 thioalkyl; m is 0; n is 0; G is —NRy-, or —NRjNRj-; Ry is J; one Rj is H and the other Rj is J; R 16 is H; or R 16 is C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl, C 0 -C 3 alkylheterocyclyl, any of which can be substituted with halo, oxo, nitrile, azido, nitro, C 1 -C 6 alkyl, C 0 -C 3 alkylcarbocyclyl, C 0 -C 3 alkylheterocyclyl, NH 2 CO—, Y—NRaRb, Y—O—Rb, Y—C(O)Rb, Y—(C═O)NRaRb, Y—NRaC(═O)Rb, Y—NHSO p Rb, Y—S(═O) p Rb, Y—S(═O) p NRaRb, Y—C(O)ORb, Y—NRaC(O)ORb; or a pharmaceutically acceptable salt or thereof.