Patent ID: 7736860

Claim:
A method of identifying a candidate compound useful in the treatment, prevention, or delay of development or progression of a condition associated with sterile inflammation induced by cell death, the method comprising: providing a sample comprising MyD88; contacting the sample with one or more test compounds; and detecting specific binding of a test compound to the MyD88 in the sample; selecting a test compound that binds specifically to the MyD88; providing a cell comprising functional MyD88, IL-1 and IL-1 receptor; contacting the cell with the test compound; assaying MyD88/IL-1 signalling in the cell in the presence of the test compound; wherein a test compound that inhibits MyD88/IL-1 signalling in the cell is a candidate compound useful in the treatment, prevention, or delay of development or progression of a condition associated with sterile inflammation induced by cell death.