Patent ID: 6897201

Claim:
A method of reducing intraocular pressure comprising administering to a subject a pharmaceutical composition comprising an effective amount of a compound of Formula I, its diastereomers, enantiomers, tautomers, or pharmaceutically acceptable salts thereof: wherein: X 1 =O or S; X 2 =H, F, Cl, Br, I, CN or alkyl; X 3 =H; R 4 =H; E=O; E 1 and E 2 independently are H or F; Y 1 M 1 and Y 2 M 2 are independently OH, F, or H; Z=O, NH, CH 2 , CHF, CF 2 , CCl 2 , or CHCl; Z 1 and Z 2 are independently O or S; G 1 =O or S; G 2 =CH; G 3 =CH 2 , CHF, CF 2 , CH(OH) or CH(NHJ 7 ); G 4 =CH 2 , CHF, CF 2 , CH(OH) or CH(NHJ 13 ); G 5 =CH 2 , CHF, CF 2 , CH(OH) or CH(NHJ 17 ); G 6 =CH 2 , CH(CH 2 OH); the number of hydrogen atoms bonded to the G 1 -G 6 ring atoms is limited to a maximum of 8; also with the provision that the number of nitrogen atoms bonded to the G 1 -G 6 ring atoms in Formula I is limited to a maximum of 2; J 7 , J 13 , and J 17 are independently H, C(O)H, or C(O)alkyl.