Patent ID: 8524714

Claim:
A combination of a compound with a chemotherapeutic agent wherein said compound is a compound of an N-oxide form, a pharmaceutically acceptable salt or a stereo-chemically isomeric form thereof, wherein n is 0, 1 or 2; X is N or CR 7 , wherein R 7 is hydrogen; R 1 is C 1-6 alkyl; R 2 is hydrogen, hydroxy, C 1-6 alkyl, or C 3-6 alkynyl; R 3 is a radical selected from —(CH 2 ) s —NR 8 R 9 (a-1), —O—H (a-2), or —O—R 10 (a-3), wherein s is 0, 1, 2 or 3; R 8 and R 10 are each independently selected from —CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonylamino C 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, piperidinyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, thienylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindozolylpiperidinylC 1-6 alkyl, or arylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl; and R 9 is hydrogen or C 1-6 alkyl; or R 3 is a group of formula —(CH 2 ) t —Z— (b-1), wherein t is 0,1,2 or 3; Z is a heterocyclic ring system selected from wherein each R 12 independently is hydrogen, halo, C 1-6 alkyl, aminocarbonyl, amino, hydroxy, aryl, C 1-6 alkylaminoC 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, arylC 1 - 6 alkyl, di(phenyl)C 1-6 alkenyl, piperidinyl, piperidinylC 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, arylC 1-6 alkylamino, morpholino, C 1-6 alkylimidazolyl, or pyridinylC 1-6 alkylamino; each R 13 independently is hydrogen, piperidinyl or aryl; R 4 , R 5 and R 6 are each independently selected from hydrogen, halo, trihalomethyl, trihalomethoxy, C 1-6 alkyl, C 1-6 alkyloxy, amino, aminoC 1-6 alkyl, di(C 1-6 alkyl)amino, di(C 1-6 alkyl)aminoC 1-6 alkyloxy or C 1-6 alkyloxycarbonyl, or C 1-6 alkyl substituted with 1, 2 or 3 substituents independently selected from hydroxy, C 1-6 alkyloxy, or aminoC 1-6 alkyloxy; aryl is phenyl or phenyl substituted with halo, C 1-6 alkyl or C 1-6 alkyloxy.