Patent ID: 8716243

Claim:
A method for modulating Dickkopf (Dkk) activity in a cell, said method comprising a step of decreasing Dkk activity in said cell by administering to said cell a compound that disrupts the interaction of a Dkk polypeptide with an LDL receptor-related protein (LRP) polypeptide, wherein the compound is a low density lipoprotein receptor-related protein 5 or 6 (LRP5 or LRP6) third propeller domain (LRP5-PD3 or LRP6-PD3) or a modification thereof having one or more conservative substitutions, wherein said LRP5-PD3, LRP6-PD3 or modification thereof has an amino acid sequence having at least 85% identity to SEQ ID NO:4, wherein said compound does not comprise a full length LRP.