Patent ID: 7129357

Claim:
A process of making a compound of formula IV comprising: (1) reacting a compound of formula V with a compound of formula VI to yield a compound of formula VII: wherein A is selected from the group consisting of H, alkyl, cycloalkyl, heterocyclyl, —CF 3 , aryl, and heteroaryl; M is selected from the group consisting of Br, Cl, I, —CN, —C(O)OR, —C(O)NR 1 R 2 , and —C(O)SR 3 ; Z is selected from the group consisting of halogen, —OR 4 , —NR 5 R 6 and —SR 7 ; R is selected from the group consisting of H, alkyl, aryl, aralkyl, heteroaryl, cycloalkyl, and heterocyclyl; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 , which can be the same or different, are each independently selected from the group consisting of H, alkyl, aryl, aralkyl, heteroaryl, cycloalkyl, and heterocyclyl, wherein said alkyl, aryl, aralkyl, heteroaryl, cycloalkyl, and heterocyclyl can each be unsubstituted or substituted with 1–4 independently selected W moieties, which can be the same or different, wherein W is selected from the group consisting of alkyl, halo, cycloalkyl, heterocyclyl, aryl and heteroaryl; (2) cyclizing the compound of formula VII to yield a compound of formula VIII: (3) converting the compound of formula VIII to yield a compound of formula IX: and (4) reacting the compound of formula IX with a compound of formula X to yield the compound of formula IV: