Patent ID: 8759557

Claim:
A method of preparing a compound having Formula II wherein: A 1 is selected from the group consisting of CH 2 , CH═CH and C═O; A 2 is CH 2 ; R 1 is an alkyl having 1-30 carbon atoms; R 2 is wherein: X is an alkyl chain having 1-24 carbon atoms; Y is selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy, halide, acetoxy and an aromatic functional group; and Z is R 3 is hydrogen, alkyl, aryl, or a phosphorus-containing moiety selected from, the group consisting of phosphoric acid, phosphoryl choline, phosphoryl ethanolamine, phosphoryl serine, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, phosphatidyl cardiolipin, phosphatidyl inositol, phosphoryl cardiolipin, phosphoryl inositol, ethylphosphocholine, phosphorylmethanol, phosphorylethanol, phosphorylpropanol, phosphorylbutanol, phosphorylethanolamine-N-lactose, phosphoethanolamine-N-[methoxy(propylene glycol)], phosphoinositol-4-phosphate, phosphoinositol -4,5-biphosplionate, pyrophosphate, phosphoethanolamine -diethylenetriamine-pentaacetate, dinitrophenyl-phosphoethanolamine, and phosphoglycerol, the method comprising: providing a compound of Formula I, having a glycerolic backbone and at least one free hydroxyl group at the sn-2 position of said glycerolic backbone: wherein: A 1 is absent or is selected from the group consisting of CH 2 , CH═CH, and C═O; R 1 is H or a hydrocarbon chain having from 1 to 30 carbon atoms; and R 3 is as defined above; reacting the compound of Formula I and a compound haven. at least one, oxidized moiety and at least one reactive group, wherein the oxidized moiety is a carboxylic ester, to obtain a compound having a glycerolic backbone and at least one carboxylic ester-containing residue; and hydrolyzing the carboxylic ester to form Z; thereby forming the compound of Formula II.