Patent ID: 8664376

Claim:
A pharmaceutical composition comprising a drug carrier and a double-stranded nucleic acid molecule, wherein the drug carrier comprises a stellate cell-specific amount of a diVA-PEG-diVA molecule retinoid and wherein the double-stranded nucleic acid molecule comprises the structure: 5′(N) x —Z 3′ (antisense strand) 3′Z′—(N′) y - z″ 5′ (sense strand) wherein each of N and N′ is a nucleotide which may be unmodified or modified, or an unconventional moiety; wherein each of (N) x and (N′) y is an oligonucleotide in which each consecutive N or N′ is joined to the next N or N′ by a covalent bond; wherein each of Z and Z′ is independently present or absent, but if present independently includes 1-5 consecutive nucleotides or non-nucleotide moieties or a combination thereof covalently attached at the 3′-terminus of the strand in which it is present; wherein z″ may be present or absent, but if present is a capping moiety covalently attached at the 5′-terminus of (N′) y ; wherein each of x and y is independently an integer between 18 and 40; wherein the sequence of (N′) y has complementary to the sequence of (N) x ; and wherein (N) x includes an antisense sequence to the mRNA coding sequence for human hsp47 exemplified by SEQ ID NO:1.