Patent ID: 8604099

Claim:
A hydrated, biocompatible tissue-reactive composition comprising: at least one NCO-terminated hydrophilic urethane prepolymer derived from reaction of an organic polyisocyanate with oxyethylene-based diols or polyols in an isocyanate-to-hydroxyl ratio ranging from about 2.0 to about 2.5; wherein essentially all hydroxyl groups are capped with polyisocyanate, in which the average molecular weight of said polyisocyanate capped prepolymer is at least 3,000, wherein the oxyethylene-based diols or polyols have an average molecular weight ranging from about 3,000 to about 30,000, and wherein an isocyanate concentration in the prepolymer is between 0.05 and 0.8 milliequivalents per gram, and an aqueous solution in a prepolymer-to-aqueous solution ratio of about 1:10 to about 1:20.