Patent ID: 8492518

Claim:
An N-terminal- and/or C-terminal-chemically modified peptide, which peptide consists of an amino acid sequence consisting of a contiguous 4 to 6 amino acid segment of a reference sequence, GAQFSKTAAKGEAAAERPGEAAVA (SEQ ID NO:1), wherein the amino acid segment is selected from the group consisting of SEQ ID NO: 176 to SEQ ID NO: 180, SEQ ID NO: 196 to SEQ ID NO: 199, SEQ ID NO: 217 and SEQ ID NO: 219; wherein (i) the C-terminal amino acid of said chemically modified peptide is chemically modified and the N-terminal amino acid of the peptide is alkylated or acylated at the N-terminal amino group; or (ii) the C-terminal amino acid of said chemically modified peptide is not chemically modified and the N-terminal amino acid of the peptide is alkylated or acylated at the N-terminal amino group and is not myristoylated; with the proviso that said chemically modified peptide contains no more than 6 amino acids; and wherein said chemically modified peptide has a mucin hypersecretion-inhibiting effect when administered to a mammal in a mucin hypersecretion-inhibiting amount.