Patent ID: 8092804

Claim:
An isolated antibody or fragment thereof that specifically binds human interleukin-4 receptor alpha (hIL-4Rα), comprising a set of CDRs: HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, wherein the set of CDRs has 10 or fewer amino acid substitutions from a reference set of CDRs in which: HCDR1 has amino acid sequence SEQ ID NO: 193; HCDR2 has amino acid sequence SEQ ID NO: 194; HCDR3 has amino acid sequence SEQ ID NO: 195; LCDR1 has amino acid sequence SEQ ID NO: 198; LCDR2 has amino acid sequence SEQ ID NO: 199; and LCDR3 has amino acid sequence SEQ ID NO: 200.