Patent ID: 8703202

Claim:
A method of treating dyslipidemia and dyslipoproteinemia in a patient comprising administering to a patient an oral dosage form of a pharmaceutical composition having phospholipid surface active substance-stabilized fenofibrate microparticles, said dosage form in the form of a tablet comprising each of the following present in the indicated amounts (w/w of the tablet): about 15% to about 20% fenofibrate; about 1% to about 8% phospholipid; about 0.1% to about 0.5% of a buffer salt; about 7% to about 20% of one or more water-soluble bulking agents selected from maltodextrin and mannitol; about 3% to about 8% of a cellulosic additive present; about 12% to about 16% beads or crystals of a pharmaceutically acceptable water soluble excipient support material; about 5% to about 30% polyvinylpyrrolidone or crospovidone; about 1% to about 6% croscarmellose sodium; about 3% to about 30% granular mannitol; about 1% to about 4% sodium dodecyl sulfate; about 1% silicon dioxide; and about 1% of a stearate; wherein the fenofibrate is in the form of microparticles coated with phospholipid, wherein the phospholipid coated microparticles are embedded in a matrix comprising the water-soluble bulking agent, phospholipid that is not coated on the microparticles, the buffer salt and the cellulosic additive, and wherein the surface of the beads or crystals of the pharmaceutically acceptable water-soluble excipient is coated with the matrix.