Patent ID: 7427497

Claim:
An apparatus for conducting a plurality of microscale reactions, comprising a. a solid support comprising a first and a second reaction site, wherein each site comprises a distinct immobilized biocatalyst; b. a micro-directing element to direct an intermediate composition from the first site to the second site, wherein the biocatalyst at the first reaction site and the biocatalyst at the second reaction site are each a functional catalytic unit from sequential steps in a natural biosynthetic pathway, the apparatus further comprising a micro-directing element to direct a composition from a source to at least one said reaction site, and wherein 1) the apparatus comprises n additional reaction sites; 2) n is an integer from 1 to 50; 3) each reaction site comprises a distinct immobilized biocatalyst; and 4) the apparatus additionally comprises one or more micro-directing elements to sequentially direct a composition from the second reaction site to each of the n additional reaction sites.