Patent ID: 8435781

Claim:
A radial flow type bioreactor comprising, within a tubular reactor main body ( 6 ), a culturing space housing a culture medium-recovering porous tube ( 5 ), a spacer ( 4 ), and a porous sheet-form material ( 3 ) provided between the spacers, wherein the reactor is formed so that a culture medium supplied from at least one culture medium inlet port ( 1 ) formed in the reactor main body ( 6 ) passes through the culturing space and the culture medium-recovering porous tube ( 5 ) and flows out from a culture medium outlet port ( 2 ) connecting with one end of the porous tube ( 5 ), the porous tube ( 5 ) and the spacer ( 4 ) allowing cells to pass through, and the porous sheet-form material ( 3 ) having its surface, which is hydrophilized with a polyamino acid/urethane copolymer so that the porous sheet-form material ( 3 ) has thereon the polyamino acid/urethane copolymer, covered with a thermosensitive polymer layer, wherein the culture medium-recovering porous tube ( 5 ) is a single tube formed along the central axis of a reactor main body ( 6 ), the porous sheet-form material ( 3 ) has a pore size of 200 to 500 μm, and the spacer ( 4 ) comprises a plurality of plastic rods or a fibrous nonwoven fabric.