Patent ID: 7534425

Claim:
An in-vitro cell or cell line, in which there is expression of a functional chloride channel C1C-7, or a cell membrane preparation or an in vitro cell vesicle of said cell or cell line; wherein said cell or cell line (a) has been genetically modified to contain a transgene construct that overexpresses functional C1C-7; and at least one of the following of(b) and (c): (b) has been genetically modified to contain a transgene construct that directly reduces expression of functional chloride channels C1C-3; or (c) has been genetically modified to contain a transgene construct that directly reduces expression of functional chloride channel C1C-6; wherein the cell or cell line exhibits higher levels of expression of functional C1C-7 than of functional C1C-3 or functional C1C-6.