Patent ID: 7393854

Claim:
A compound of formula (I): wherein: R 1 and R 2 each independently represent C 1-6 alkyl, C 3-6 alkenyl, C 3-5 cycloalkylC 1-3 alkyl or C 3-6 cycloalkyl, each of which may be optionally substituted by 1 to 3 halogen atoms; Q is CR 4 R 5 where R 4 is hydrogen, fluorine or C 1-6 alkyl and R 5 is hydrogen, fluorine or hydroxy; Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms are optionally heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents independently selected from C 1-4 alkyl (optionally substituted by 1, 2 or 3 hydroxy groups), C 1-4 alkoxy, halogen, haloalkyl, dihaloalkyl, or trihaloalkyl (wherein alkyl groups suitably contain from 1 to 4 carbon atoms), C 1-4 alkoxyC 1-4 alkyl, C 1-4 alkylthio, C 1-4 alkoxycarbonyl, C 2-4 alkanoyl, nitro, cyano, —N(R 6 )R 7 and —(CH 2 )pN(R 8 )R 9 , hydroxy, C 1-4 alkylsulphonyl, C 1-4 alkylsulphinyl, carbamoyl, C 1-4 alkylcarbamoyl, di-(C 1-4 alkyl)carbamoyl, carboxy, SO 2 N(R 8 )R 9 ; Ar 2 is a 5 or 6 membered aromatic ring containing up to 4 heteroatoms independently selected from nitrogen, sulphur or oxygen, and which may be optionally substituted by one or more groups independently selected from C 1-4 alkyl (optionally substituted by 1,2 or 3 hydroxy groups), C 1-4 alkoxy, halogen, haloalkyl, dihaloalkyl, or trihaloalkyl, (wherein alkyl groups suitably contain from 1 to 4 carbon atoms) C 1-4 alkoxyC 1-4 alkyl, C 1-4 alkylthio, C 1-4 alkoxycarbonyl, C 2-4 alkanoyl, nitro, cyano, —N(R 6 )R 7 and —(CH 2 )pN(R 8 )R 9 , hydroxy, C 1-4 alkylsulphonyl, C 1-4 alkylsulphinyl, carbamoyl, C 1-4 alkylcarbamoyl, di-(C 1-4 alkyl)carbamoyl, carboxy, SO 2 N(R 8 )R 9 ; p is 1 to 4; R 6 and R 7 each independently represent a hydrogen atom, C 1-4 alkanoyl or C 1-4 alkyl group, or together with the nitrogen atom to which they are attached form a 5- to 7-membered saturated heterocyclic ring optionally containing a further O, S, NH or N-alkyl group; R 8 and R 9 each independently represent a hydrogen atom, C 1-4 alkanoyl or C 1-4 alkyl group, or together with the nitrogen atom to which they are attached form a 5- to 7-membered saturated heterocyclic ring optionally containing a further O, S, NH or N-alkvl group; or a pharmaceutically acceptable salt thereof, provided that the compound is other than 5-[(4S)-4-Hydroxyisoxazolidin-2-ylcarbonyl]-1-(isobutyl)-3-methyl-6-[5 -methyl-3-phenyl-1H-pyrazol-4-ylmethyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[[3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl]methyl]-5-[(4S)-4-hydroxyisoxazolidin-2-ylcarbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or 6-[[3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl]methyl]-5-[(4S)-4-hydroxyisoxazolidin-2-ylcarbonyl]-3-methyl-1-propylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or a pharmaceutically acceptable salt thereof.