Patent ID: 6846954

Claim:
A method for preparing an antiviral compound represented by the formula said method comprising: (a) removing, under removal conditions, amino protecting group P from an amino protected sulfonamide derivative represented by Formula (A) or amino protecting groups P 1 and P 2 from an amino protected sulfonamide derivative represented by Formula (B), wherein Formula (A) and Formula (B) are to yield a corresponding amine salt derivative represented by the formula (b) reacting said amine salt derivative with an amino acid having the formula to yield said antiviral compound, wherein: P, P 1 , and P 2 independently represent amino protecting groups selected from the group consisting of arylalkyl, aryl, cycloalkenylalkyl, allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl, and silyl, or P 1 and P 2 together with the nitrogen to which they are attached form a heterocyclic ring; R 1 represents a radical selected from the group consisting of hydrogen, —COOH, —CH 2 SO 2 NH 2 , —CH 2 CO 2 CH 3 , —CO 2 CH 3 , —CONHCH 3 , —CON(CH 3 ) 2 , —CONH 2 , —CH 2 CONHCH 3 , —CH 2 CON(CH 3 ) 2 , —C(CH 3 ) 2 SH, —C(CH 3 ) 2 SCH 3 , —C(CH 3 ) 2 SOCH 3 , —C(CH 3 ) 2 SO 2 CH 3 , alkyl, aralkyl, hydroxyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, and side chains of amino acids selected from the group consisting of asparagine, S-methyl cysteine, and the sulfoxide (SO) and sulfone (SO 2 ) derivatives of asparagine and S-methyl cysteine, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allothreonine, serine, aspartic acid, beta-cyano alanine and valine; R 1′ and R 1″ independently represent radicals selected from the group consisting of hydrogen and radicals as defined for R 1 , or one of R 1′ and R 1″ , together with R 1 and the carbon atoms to which R 1 , R 1′ , and R 1″ are attached, represent a cycloalkyl radical; R 2 represents a radical selected from the group consisting of alkyl; aryl; cycloalkyl; cycloalkylalkyl; aralkyl; and alkyl, aryl, cycloalkyl, cycloalkylalkyl, and aralkyl that is substituted with a radical selected from the group consisting of alkyl, halogen, —NO 2 , —CN, —CF 3 , —OR 9 , and —SR 9 , wherein R 9 is hydrogen or an alkyl radical; R 3 and R 4 independently represents radicals selected from the group consisting of alkyl; haloalkyl; alkenyl; alkynyl; hydroxylalkyl; alkoxyalkyl; cycloalkyl; cycloalkylalkyl; heterocycloalkyl; heteroaryl; heterocycloalkylalkyl; aryl; aralkyl; heteroaralkyl; aminoalkyl; aminoalkyl substituted at one or more carbon atoms with a radical selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl; and aminoalkyl substituted at two carbon atoms with radicals that, together with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical; and, t is 0 or 1.