Patent ID: 8404220

Claim:
A method for producing an adapalene aqueous gel, which method comprises the steps of: i) formulating a gelling medium A by mixing water, propylene glycol and a preservative agent, and adding a gelling agent thereto; ii) formulating an adapalene medium B by dispersing adapalene in water, in the presence of a surfactant; with the proviso that steps i) and ii) are carried out in parallel or any of step i) or ii) is carried out after the other; iii) adding the adapalene medium B to the gelling medium A; and iv) adjusting the pH by adding neutralizing agent thereto, whereby a gel is formed, said adapalene being in a dispersed state in said gel; said adapalene being the sole active ingredient that exhibits a cosmetic or therapeutic effect in said gel; and all steps in said method being conducted at room temperature.