Patent ID: 8206741

Claim:
A pharmaceutical composition in unit dosage form comprising therapeutically effective amounts of: (a) a proton pump inhibitor selected from the group consisting of omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole, wherein at least a portion of said proton pump inhibitor is not surrounded by an enteric coating; and (b) aspirin, wherein said aspirin is surrounded by a coating that inhibits its release from said dosage form unless said dosage form is in a medium with a pH of 3.5 or higher; wherein said unit dosage form provides for release of said proton pump inhibitor and said aspirin such that: i) upon introduction of said unit dosage form into a medium, at least a portion of said proton pump inhibitor is released regardless of the pH of the medium; and ii) said aspirin is released when the pH of said medium is 3.5 or higher.