Patent ID: 7785623

Claim:
A cosmetic method for reducing fine lines, wrinkles, or fine lines and wrinkles on an area of skin of a subject, comprising contacting a composition to the area of skin, wherein the composition comprises a liposome, a substance encapsulated within the liposome, wherein said liposome comprises polyethylene glycol (PEG)-12 glyceryl dioleate or PEG-12 glyceryl dimyristate in a sufficient quantity to induce spontaneously formed liposomes at 60° C. and in a quantity less than 20% weight to volume, and wherein the liposome has a net surface charge, and wherein the composition is a liposome suspension comprising one or more lipids, where the lipids as an aggregate have a P a between about 0.84 to 0.88, a P v between about 0.88 to 0.93, and wherein the substance encapsulated within the lipid vesicle comprises soluble collagen, vitamin A, vitamin C, vitamin E, glycolic acid, or a combination thereof, applying an electric voltage directly to said area of the skin, whereby the liposome with the net surface charge is iontophoretically induced into the skin or tissue, thereby reducing fine lines, wrinkles, or fine lines and wrinkles.