Patent ID: 8012984

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof wherein is a phenylene ring; R 1 is Z—Y—X—, wherein X is S, —SO— or —SO 2 —; Y is a bond, a 3- to 6-membered cycloalkyl, or an alkylene chain of 2 to 3 carbon atoms optionally substituted with a lower alkyl moiety; Z is aryl or heteroaryl, wherein Z may be substituted with 1, 2 or 3 of halo, C 1-6 alkyl, C 1-3 alkoxy, C 1-3 thioalkyl, C 1-3 trifluoroalkoxy, trifluoromethyl, cycloalkyl, cycloalkoxy, or heteroaryl; R 2 is -E-G-(J) m , with m being an integer from 1 to 3; E is O or S; G is lower alkyl, phenylalkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, cycloalkoxy, alkylcycloalkoxy, or cycloalkoxyalkyl; each J is independently hydrogen, OH, CN, —SO 2 R 7 , —SR 7 , —SOR 7 , lower alkyl, lower alkoxy, CF 3 , —OCF 3 , or —COOR 5 ; R 5 is H, C 1-6 alkyl, or cycloalkyl; R 7 is lower alkyl; R 3 is C 1-6 alkyl, lower cycloalkyl, C 1-6 alkoxy, halogen, hydrogen, or —S—C 1-6 alkyl; R 8 and R 9 are each independently hydrogen, halogen, or lower alkyl; with the proviso that E-G and R 3 are not identical unsubstituted lower alkoxy groups; and when G is lower alkyl and J is H, R 3 is not hydrogen; and prodrugs thereof selected from the group consisting of acetates, pivalates, methylcarbonates, benzoates, amino acid esters, phosphates, malonates, succinates and glutarates; and all stereoisomers thereof.