Patent ID: 8178547

Claim:
A compound according to formula I wherein: A is a heteroaryl radical selected from the group consisting of 6-oxo-1,6-dihydro-pyrimidin-5-yl and 4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-5-yl said heteroaryl being optionally substituted by halogen, C 1-6 alkyl, C 1-3 haloalkyl, C 1-3 dialkylamino or C 1-6 alkoxy; R 1 is hydrogen, hydroxy, C 1-3 hydroxyalkyl, COX or cyano; R 2 is (a) —[C(R 6 ) 2 ] p —Ar 1 , (b) CR 7a ═CR 7b Ar 1 , (c) naphthyl optionally substituted by one to three groups independently selected from the group consisting of C 1-6 alkoxy, C 1-6 alkyl, C 1-6 hydroxyalkyl, halogen, (CH 2 ) n NR c R d , cyano, C 1-6 alkoxycarbonyl, and carboxyl (d) —NR 5 COAr 1 or (e) CONR 5 Ar 1 ; R 3 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, halogen or R 3 and R 4a together are CH 2 —O and together with atoms to which they are attached form a 2,3-dihydrobenzofuran; R 4a , R 4b and R 4c (i) when taken independently are selected independently from C 1-3 alkyl, C 1-2 alkoxy, C 1-2 fluoroalkyl, hydroxy or halogen or (ii) when taken together, R 4a and R 4b together are C 2-4 alkylene and R 4c is C 1-3 alkyl, C 1-2 alkoxy, C 1-2 fluoroalkyl or halogen, or (iii) either R 8 or R 3 and R 4a together are CH 2 —O and together with atoms to which they are attached for a 2,3-dihydro-benzofuran and R 4b and R 4c are C 1-3 alkyl, or (iv) R 4a and R 4b together are ethylene and R 4c is hydrogen, or (v) R 4a , R 4b and R 4c together with the carbon to which they are attached are C 1-6 fluoroalkyl; R 8 is hydrogen, fluorine or R 8 and R 4a together are CH 2 —O and together with atoms to which they are attached form a 2,3-dihydrobenzofuran; R 5 is hydrogen or C 1-6 alkyl; R 6 is independently in each occurrence hydrogen, C 1-6 alkyl, C 1-6 alkoxycarbonyl, carboxy or C 1-6 hydroxyalkyl; R 7a and R 7b independently hydrogen or C 1-6 alkyl; Ar 1 is phenyl or pyridinyl optionally independently substituted with one to three substitutents selected from the group consisting of hydroxy, C 1-6 alkoxy, C 1-6 alkyl, C 1-6 hydroxyalkyl, halogen, (CH 2 ) n NR c R d , cyano, C 1-6 alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl and carboxyl; R c and R d are independently in hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 acyl, C 1-6 sulfonyl, sulfamoyl C 1-3 alkylsulfamoyl, C 1-3 dialkylsulfamoyl, carbamoyl, C 1-3 alkylcarbamoyl, or C 1-3 dialkylcarbamoyl; X is OH, C 1-6 alkoxy or NR e R f ; R e and R f are independently hydrogen or C 1-6 alkyl; n is zero or 1; p is zero to three; or, a pharmaceutically acceptable salt thereof.