Patent ID: 7968723

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein X 1 is aryl or heteroaryl each of which is optionally substituted with one or more substituents, where said substituents independently are: halogen, hydroxy, cyano, amino or carboxy; or C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aralkyl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylcarbonyl, arylcarbonyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylsulfonyloxy, arylsulfonyl, arylsulfonyloxy, C 1-6 -alkylamido, arylamido, C 1-6 -alkylaminocarbonyl, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted independently with one or more of halogen or hydroxy; X 2 is aryl or heteroaryl each of which is optionally substituted with one or more substituents, where said substituents independently are: halogen, hydroxy, cyano, amino or carboxy; or C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aralkyl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylcarbonyl, arylcarbonyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylsulfonyloxy, arylsulfonyl, arylsulfonyloxy, C 1-6 -alkylamido, arylamido, C 1-6 -alkylaminocarbonyl, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted independently with one or more of halogen or hydroxy; Ar 1 is arylene or heteroarylene; Ar 2 is arylene which is optionally substituted with one or more substituents, where said substituents independently are: halogen, hydroxy or cyano; or C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio or C 3-6 -cycloalkylthio each of which is optionally substituted independently with one or more halogens; or two of the substituents when placed in adjacent positions together with the atoms to which they are attached may form a five to eight member ring; Y 1 is O or S; Y 2 is O or S; Z 1 is (CH 2 ) n — wherein n is 0, 1, or 2; Z 2 is —(CH 2 ) m — wherein m is 1, 2 or 3; and R is hydrogen, C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 4-6 -alkenynyl or aryl.