Patent ID: 8855761

Claim:
A method of predicting worsening of heart failure in a patient, comprising: obtaining, by a processor, time domain temperature data (TDTD) of core body temperature of the patient taken over a time period of more than one day; converting, by said processor, said TDTD to a frequency domain representation (FDR); determining, by said processor, a first marker indicative of worsening of heart failure of the patient by analyzing the FDR; determining, by said processor, a second marker indicative of worsening of heart failure by analyzing the TDTD, wherein analyzing the TDTD comprises performing at least one of Cosinor analysis, approximate entropy, tempogram, day-night mean temperature difference, body temperature daily range, interdaily stability, and time-lag embedding; weighing outputs of at least two analysis techniques to render a total score indicative of the current condition of the patient, wherein the at least two analysis techniques comprise a technique for analyzing the TDTD and another technique for analyzing the FDR; and determining that the patient is experiencing worsening heart failure based on the total score.