Patent ID: 7001914

Claim:
A compound of formula I: wherein: A is D is oxygen or sulfur; E is a single bond, oxygen, sulfur, or NR 10 ; Ar 1 is a 5-membered heteroaromatic ring containing one, oxygen atom; Ar 2 is a phenyl or a 5- or 6-membered aromatic or heteroaromatic ring containing 1, 2 or 3 atoms selected from nitrogen, oxygen or sulfur atoms, wherein there is no more than 2 oxygen or sulfur atom; or naphthyl or an 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system containing 1, 2 or 3 nitrogen, oxygen or sulfur atoms, wherein there is no more than 2 oxygen or sulfur atoms; wherein the aromatic rings Ar 1 and Ar 2 are substituted with 0, 1, 2 or 3 substituents selected from halogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, NO 2 , NR 1 R 2 , CH 2 NR 1 R 2 , OR 3 , CH 2 OR 3 , CO 2 R 4 and CF 3 ; but if Ar 1 is phenyl and Ar 2 is quinolynyl, then Ar 2 is substituted with 0, 1, 2 or 3 substituents selected from C 1-4 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, NO 2 , NR 1 R 2 , CH 2 NR 1 R 2 , OR 3 , CH 2 OR 3 and CO 2 R 4 ; R 1 , R 2 , and R 3 are independently C 1-4 alkyl, aryl, heteroaryl, C(O)R 5 , C(O)NHR 6 , C(O)R 7 , SO 2 R 8 ; or R 1 and R 2 may together be (CH 2 ) j G(CH 2 ) k where G is oxygen, sulfur, NR 9 , or a single bond; j is 2, 3 or 4; k is 0, 1 or 2; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are independently C 1-4 alkyl, aryl, or heteroaryl; or an enantiomer thereof or pharmaceutically-acceptable salts thereof; with the proviso that: if D represents oxygen, E represents a single bond, and A represents: and Ar 2 represents a pyrazole ring, then all optional substituents on the pyrazole ring shall be hydrogen.