Patent ID: 8309586

Claim:
A method for lowering blood glucose level comprising: administering a pharmaceutical composition which comprises an indole compound of the following formula (1), or pharmaceutically acceptable salt or isomers thereof, as an active ingredient together with a pharmaceutically acceptable carrier: in which X represents NH, n denotes a number of 0 to 3, Y represents a direct bond, —(CH 2 ) p O—, —(CH 2 ) q —, or —(CH 2 ) q SO 2 —, p denotes a number of 0 to 2, q denotes a number of 1 to 3, R1 represents —(CR4R5) p -A-R6 , wherein p is as defined above, R4 and R5 independently of one another represent hydrogen or C 1 -C 5 -alkyl, A represents 6˜12 membered aryl or optionally oxo-containing C 3 -C 8 -cycloalkyl, or represents 3˜10 membered heterocyclyl or heteroaryl each of which has 1 to 3 hetero atoms selected from O, S, and N, R6 represents hydrogen, hydroxy, halogen, nitro, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -alkoxycarbonyl or carboxy, R2 represents nitro, halogen, C 1 -C 6 -alkyl or trifluoromethyl, represents 5˜12 membered heteroaryl or heterocyclyl each of which has 1 to 3 hetero atoms selected from N and O, or represents optionally C 1 -C 6 -alkylsulfonyl-substituted 6˜12 membered aryl, R3 represents R7-X—B—X′—, B represents a direct bond, or represents 3˜10 membered heterocyclyl or heteroaryl each of which optionally contains oxo, is optionally fused, and has 1 to 4 hetero atoms selected from N, O and S, X and X′ independently of one another represent a direct bond, or are selected from the group consisting of —CO—, —(CH 2 ) q —, —NR4C(O)—, —NR4-, —OC(O)—, —O—, —(CH 2 ) p C(O)—, —(CH 2 ) p O—, —(CH 2 ) p NR4-, —C(O)NR4- and —S(O) r —, wherein p and q are as defined above, r denotes a number of 0 to 2, and R4 represents hydrogen or C 1 -C 5 -alkyl, R7 represents hydrogen, hydroxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halogeno-C 1 -C 6 -alkyl or C 3 -C 6 -cycloalkyl, represents 6˜12 membered aryl, or represents 4˜8 membered heteroaryl or heterocyclyl each of which has 1 to 4 hetero atoms selected from N and O, where alkyl, alkoxy, aryl, cycloalkyl, heterocyclyl and heteroaryl may be optionally substituted, and the substituents are one or more selected from the group consisting of hydroxy, halogen, nitrile, amino, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkyl, halogeno-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfonyl, aryl-C 1 -C 6 -alkoxy and oxo.