Patent ID: 8143277

Claim:
A method of producing bronchodilation in a patient, the method comprising administering to a patient a bronchodilation-producing amount of a compound of formula I: wherein W represents O; R 1 is (2-9C)heteroaryl containing from 1 to 4 heteroatoms independently selected from oxygen, nitrogen and sulfur or cyclohexyl; wherein the heteroaryl group is unsubstituted or substituted with 1 or 2 substituents independently selected from (1-4C)alkyl and halo; R 4 represents a divalent hydrocarbon group containing from 4 to 28 carbon atoms and optionally containing from 1 to 10 heteroatoms selected independently from halo, oxygen, nitrogen and sulfur, provided that the number of contiguous atoms in the shortest chain between the two nitrogen atoms to which R 4 is attached is in the range of from 4 to 16; R 5 represents hydrogen; R 6 and R 7 together form —N(R 7a )C(O)C(R 7b )═C(R 7c )—, —C(R 7d )═C(R 7e )C(O)N(R 7f )—, —N(R 7g )C(O)CR 7h R 7i —CR 7j R 7k — or —CR 7l R 7m —CR 7n R 7o C(O)—N(R 7p )—; where each of R 7a , R 7b , R 7c , R 7d , R 7e , R 7f , R 7g , R 7h , R 7i , R 7j , R 7k , R 7l , R 7m , R 7n , R 7o and R 7p is independently selected from hydrogen and (1-4C)alkyl; each R 8a and R 8b is hydrogen; a is 0; b is 0 or an integer of from 1 to 5; c is 0; m is 2; or a pharmaceutically acceptable salt or stereoisomer thereof.