Patent ID: 7541471

Claim:
A process for preparing Compound 1: wherein R 1 and R 2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, and heteroaryl; and R 8 is selected from the group consisting of halogen, —CF 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, and —COOR 9 , wherein R 9 is selected from the group consisting of H, C 1 -C 6 alkyl, phenyl, and benzyl, said process comprising: (a) reducing a Compound 2A: wherein R 2 is as defined above, and R 3 is H, alkyl, cycloalkyl, aryl, arylalkyl or heteroaryl; R 4 and R 5 are each independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, arylalkyl, and heteroaryl; or, R 4 and R 5 , together with the carbon atom to which they are attached, form a 5- to 7- membered ring having from 0-3 heteroatoms as ring members, to form 2B; followed by hydrolysis of 2B to yield a compound of formula 3: wherein R 2 is as defined above; (b) aminating Compound 3 to yield Compound 4: wherein R 2 is as defined above, and R 6 and R 7 are each independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, and heteroaryl; (c) converting Compound 4 to Compound 5: wherein R 1 and R 2 are as defined above; (d) converting Compound 5 to Compound 6: wherein R 1 and R 2 are as defined above; and (e) converting Compound 6 to compound 1