Patent ID: 8034792

Claim:
A method of treating a tumor in a subject, the method comprising: identifying a subject having, at risk for, or suspected of having a tumor; determining whether a cell of the tumor has increased Ras-BRAF-MEK-Erk signaling, is dependent for growth and/or survival upon the Ras-BRAF-MEK-Erk signaling pathway, and/or expresses an activated or oncogenic BRAF or RAS; and administering to the subject an effective amount of an IGFBP7 agent if the tumor has increased Ras-BRAF-MEK-Erk signaling, is dependent for growth and/or survival upon the Ras-BRAF-MEK-Erk signaling pathway, and/or expresses an activated or oncogenic BRAF or RAS, thereby treating the tumor, wherein the IGFBP-7 agent comprises a polypeptide at least 80% identical to SEQ ID NO:7 or residues 29 to 282 SEQ ID NO:1.