Patent ID: 8460659

Claim:
A method of treating type II diabetes, hyperglycemia or hyperinsulinemia comprising administering a therapeutically effective amount of an isolated antibody reactive with toll-like receptor 3 (TLR3) to a patient in need thereof for a time sufficient to treat type II diabetes, hyperglycemia or hyperinsulinemia, wherein the isolate antibody reactive with TLR3 comprises (i) heavy chain complementarity determining regions 1, 2 and 3 (HCDR1, HCDR2, HCDR3) having the amino acid sequences shown in SEQ ID NOs: 70, 77 and 72 and light chain (LC) complementarity determining regions 1, 2 and 3 (LCDRI, LCDR2, LCDR3) having the amino acid sequences shown in SEQ ID NOs: 67, 68 and 78, or (ii) HCDR1, HCDR2 and HCDR3 regions having the amino acid sequences shown in SEQ ID NOs: 82, 86 and 84 and LCDR1, LCDR2 and LCDR3 regions having the amino acid sequences shown in SEQ ID NOs: 79, 80 and 87.