Patent ID: 8680315

Claim:
A compound of the formula wherein m is an integer of 1-10; Z is a macromolecule; L′ is a linker; D is a drug or of a prodrug; X is O or S; A is alkenyl (C 2 ), aryl or absent; each R 1 and R 2 is independently H; CN; NO 2 ; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted alkenyl; optionally substituted alkynyl; or each R 1 and R 2 is independently COR 3 or SOR 3 or SO 2 R 3 wherein R 3 is H or optionally substituted alkyl; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted alkenyl; optionally substituted alkynyl; or OR or NR 2 wherein each R is independently H or optionally substituted alkyl; or each R 1 and R 2 is independently SR 4 wherein R 4 is optionally substituted alkyl; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted alkenyl; or optionally substituted alkynyl; wherein R 1 and R 2 may be joined to form a 3-8 member ring; and wherein both R 1 and R 2 cannot be H; wherein R 5 is H or alkyl (C 1-6 ).