Patent ID: 8691791

Claim:
A method of treatment of a brain tumor comprising introducing into the brain a composition comprising microspheres, wherein the microspheres comprise a water-insoluble, water-swellable, non-biodegradable, biocompatible polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, wherein in the treatment the chemotherapeutic agent is released from the microspheres; and wherein when equilibrated in water at 37° C., the microspheres comprise at least 40 wt % water based on weight of polymer plus water and have diameters in the range of 50 to 500 μm, wherein the composition additionally comprises a viscosity modifier which gels after administration into the brain and increases the viscosity of the composition, the viscosity modifier comprising alginate, and in the treatment, the composition is injected into the brain.