Patent ID: 7645449

Claim:
A method for the down-regulation of an anti-apoptotic protein in a non-lymphoid or non-myeloid tumor of a subject, the method comprising the steps of: (a) selecting a subject having a non-lymphoid or non-myeloid tumor producing a higher level of a cytokine as compared with normal tissue, wherein the cytokine is selected from the group consisting of interleukin (IL)4, IL-5, IL-10, IL-13, and combinations thereof and having a higher level of an anti-apoptotic protein than a comparable control sample; (b) contacting the non-lymphoid or non-lymphoid tumor with a cytokine antagonist; wherein the anti-apoptotic protein in the non-lymphoid or non-myeloid tumor is down-regulated; and wherein cells of the non-lymphoid or non-myeloid tumor are sensitized for cell death; and (c) administering to the subject an active compound or radiotherapy.