Patent ID: 7402674

Claim:
A compound of the formula I in which the meanings are R1 is OH, O—(C 1 -C 6 )-alkyl or O—(C 1 -C 6 )-alkyl-OCO—(C 1 -C 6 )-alkyl; R2 is H, (C 1 -C 6 )-alkyl or phenyl; R3 is H, (C 1 -C 8 )-alkyl, (C 3 -C 7 )-cycloalkyl, pyridyl or phenyl, wherein (C 1 -C 8 )-alkyl and (C 3 -C 7 )-cycloalkyl may be substituted by R9 and wherein said phenyl and pyridyl may be substituted by R10; R9 is NH 2 , NH—(C 1 -C 6 )-alkyl, N—((C 1 -C 6 )-alkyl) 2 , COOH, COO—(C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, heteroalkyl, heteroaryl, O-phenyl or phenyl, wherein said heteroaryl, O-phenyl and phenyl may be substituted by R11; R10 is F, Cl, Br, (C 1 -C 6 -alkyl), O—(C 1 -C 6 )-alkyl, COOH, COO—(C 1 -C 6 )-alkyl, NH 2 , NH—(C 1 -C 6 )-alkyl or N—((C 1 -C 6 )-alkyl) 2 ; R11 is F, Cl, (C 1 -C 6 -alkyl), O—(C 1 -C 6 )-alkyl, NH 2 , NH—(C 1 -C 6 )-alkyl, N—((C 1 -C 6 )-alkyl) 2 , COOH or COO—(C 1 -C 4 )-alkyl; X is C—R4 or N; R4 is H, F, Cl, Br, OH, NO 2 , CN, (C 1 -C 6 )-alkyl or O—(C 1 -C 6 )-alkyl, wherein said (C 1 -C 6 )-alkyl and O—(C 1 -C 6 )-alkyl may be substituted more than once by F, Cl or Br; R5 is H, F, Cl, Br, OH, NO 2 , CN, (C 1 -C 6 )-alkyl or O—(C 1 -C 6 )-alkyl, where said (C 1 -C 6 )-alkyl and O—(C 1 -C 6 )-alkyl may be substituted more than once by F, Cl or Br; R6 is H, F, Cl, Br, NO 2 , CN or (C 1 -C 6 )-alkyl, wherein said (C 1 -C 6 )-alkyl may be substituted more than once by F, Cl or Br; R7 is H or (C 1 -C 6 )-alkyl; R8 is phenyl, wherein said phenyl may be substituted up to five times by F, Cl, Br, CN, NO 2 , (C 1 -C 8 )-alkyl, O—(C 1 -C 8 )-alkyl, S—(C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 3 -C 7 )-cycloalkyl, CO—(C 1 -C 4 )-alkyl, phenyl, benzyl, benzoyl, NH 2 , NH—(C 1 -C 6 )-alkyl, N—((C 1 -C 6 )-alkyl) 2 , P(O)—(O—(C 1 -C 4 )-alkyl) 2 or heteroalkyl, wherein said (C 1 -C 8 )-alkyl, O—(C 1 -C 8 )-alkyl, S—(C 1 -C 8 )-alkyl, (C 2 -C 8 )-alkenyl, (C 3 -C 7 )-cycloalkyl, CO—(C 1 -C 4 )-alkyl, NH—(C 1 -C 6 )-alkyl, N—((C 1 -C 6 )-alkyl) 2 , P(O)—(O—(C 1 -C 4 )-alkyl) 2 and heteroalkyl may be substituted more than once by F, Cl, Br, COOH, or COO—(C 1 -C 4 )-alkyl; heteroalkyl is heterocyclic, saturated or unsaturated 4- to 7-membered ring which may comprise up to 3 heteroatoms N, O or S as ring members, wherein said ring may be substituted by F, Cl, Br, CN, NO 2 , (C 1 -C 4 )-alkyl, OH, COOH or COO—(C 1 -C 4 )-alkyl; with the exception of compounds of the formula I in which the radicals simultaneously have the following meaning: X equal to N, R1 equal to OH, R2, R3, R4, R5 and R7 equal to H and R8 equal to unsubstituted phenyl; and the physiologically tolerated salts thereof.