Patent ID: 7932231

Claim:
A method of stimulating the motility of the gastrointestinal system in a patient, said method comprising administering a peptidyl analog of ghrelin to a patient in need thereof wherein said peptidyl analog of ghrelin comprises the following formula (II): R 1 - A 1 - A 2 - A 3 - A 4 - A 5 - R 2 (II) wherein: A 1 is Aib, Apc or Inp; A 2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1-Nal, D-2-Nal, D-Ser(Bzl), or D-Trp; A 3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1-Nal, D-2-Nal, D-Ser(Bzl), or D-Trp; A 4 is 2-Fua, Orn, 2-Pal, 3-Pal, 4-Pal, Pff, Phe, Pim, Taz, 2-Thi, 3-Thi, Thr(Bzl); A 5 is Apc, Dab, Dap, Lys, Orn, or deleted; R 1 is hydrogen, (C 1-6 )alkyl, (C 5-14 )aryl, (C 1-6 )alkyl(C 5-14 )aryl, (C 3-8 )cycloakyl, or (C 2-10 )acyl; and R 2 is OH or NH 2 ; provided that when A 5 is Dab, Dap, Lys, or Orn, then: A 2 is D-Bip, D-Bpa, D-Dip or D-Bal; or A 3 is D-Bip, D-Bpa, D-Dip or D-Bal; or A 4 is 2-Thi, 3-Thi, Taz, 2-Fua, 2-Pal, 3-Pal, 4-Pal, Orn, Thr(Bzl), or Pff; when A 5 is deleted, then: A 3 is D-Bip, D-Bpa, or D-Dip; or A 4 is 2-Fua, Pff, Taz, or Thr(Bzl); or A 1 is Apc when A 2 is D-Bip, D-Bpa, D-Dip or D-Bal; or A 3 is D-Bip, D-Bpa, D-Dip or D-Bal; or A 4 is 2-Thi, 3-Thi, Orn, 2-Pal, 3-Pal or 4-Pal; or a pharmaceutically acceptable salt thereof.