Patent ID: 7101562

Claim:
An immunogenic composition comprising a purified cariogenic mutans streptococcal glucan and an isolated cariogenic mutans streptococcal glucosyltransferase (GTF), a recombinant fusion protein of said GTF, or an immunogenic peptide of said GTF, wherein the cariogenic mutans streptococcal GTF, the recombinant fusion protein of said GTF, or the immunogenic peptide of said GTF is covalently conjugated to the cariogenic mutans streptococcal glucan by an isourea bond formed by 1-cyano-4-dimethylamino-pyridinium-tetrafluoroborate (CDAP) activation, and wherein the immunogenic composition elicits antibodies to both the cariogenic mutans streptococcal glucan and the cariogenic mutans streptococcal GTF, the recombinant fusion protein of said GTF, or the immunogenic peptide of said GTF.