Patent ID: 8748433

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof: wherein the dash bond “ ” means a single or double bond while conforming to the valency rule for the ring atoms; m is 0, 1, 2 or 3; n is 0, 1, 2, 3 or 4; p is 0, 1 or 2; U is —CH═ or —N═; V is selected from the group consisting of: (1) —O—, (2) —N═, and (3) —NR 3 —; W is —N═ or —NR 3 —; X is selected from the group consisting of: (1) a bond, and (2) C 1 -C 4 alkanediyl optionally substituted with 1 to 3 groups independently selected from: (a) hydroxy, (b) halogen, (c) —CO 2 R 3 , (d) —CONR 3 R 3 , and (e) —NR 3 R 3 ; Z is selected from the group consisting of: (1) phenyl, (2) 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen, (3) a C 5 -C 8 carbocyclic ring fused to a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen, and (4) 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen fused to a 5 or 6-membered heterocyclic ring with from 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen; each occurrence of R 1 is independently selected from the group consisting of: (1) C 1 -C 4 alkyl optionally substituted with 1 to 3 groups independently selected from: (a) hydroxy, (b) halogen, and (c) C 3 -C 8 cycloalkyl; (2) C 3 -C 8 cycloalkyl, (3) oxo, and (4) halogen; each occurrence of R 2 is independently selected from the group consisting of: (1) hydroxy, (2) halogen, (3) oxo, (4) —CO 2 R 3 , (5) C 3 -C 8 cycloalkyl, (6) —S(O) p —C 1 -C 4 alkyl, (7) C 1 -C 4 alkyl optionally substituted with 1 to 3 groups independently selected from (a) hydroxy, (b) halogen, (c) —CO 2 R 3 , (d) —S(O) p —C 1 -C 4 alkyl, (e) C 3 -C 8 cycloalkyl, and (f) Z optionally substituted with 1 to 4 groups independently selected from hydroxyl, halogen, oxo, trifluoromethyl, trifluoromethoxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, and —CO 2 R 3 , and (8) Z optionally substituted with 1 to 4 groups independently selected from hydroxyl, halogen, oxo, trifluoromethyl, trifluoromethoxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, —SO 2 —CH 3 , and —CO 2 R 3 ; and each occurrence of R 3 is independently selected from the group consisting of: (1) hydrogen, and (2) C 1 -C 4 alkyl optionally substituted with 1 to 2 groups independently selected from phenyl, halogen, cyano and hydroxyl.