Patent ID: 8206704

Claim:
A method of treating an individual who has metastasized colorectal cancer or primary or metastasized gastric or esophageal cancer in an individual who has been identified as having metastasized colorectal cancer or primary or metastasized gastric or esophageal cancer, said method comprising the steps in the following order: a) administering to said individual a cytostatically effective amount of a guanylyl cyclase C ligand sufficient to inhibit cell proliferation by the cytostatic effect of the guanylyl cyclase C ligand for at least 6 hours wherein, wherein said guanylyl cycles C ligand activates guanylyl cyclase C on cancer cells, and stimulates accumulation of intracellular cGMP, and b) subsequently after administration of said guanylyl cycles C ligand is completed administering a therapeutically effective amount of a cytotoxic therapeutic agent or radiation, wherein effectiveness of said therapeutically effective amount of a cytotoxic therapeutic agent or radiation is enhanced by prior inhibition of proliferation of cancer cells by said cytostatically effective amount of said guanylyl cyclase C ligand.