Patent ID: 7615543

Claim:
A method for the treatment of tissue damage in a subject having an inflammatory and/or tissue damaging condition caused by C-reactive protein (CRP) comprising atherosclerosis, an inflammatory disease, ischemic or other necrosis, traumatic tissue damage, malignant neoplasia, a bacterial infection, a viral infection, a parasitic infection, or an allergic complication of infection selected from the group consisting of rheumatic fever, glomerulonephritis, and erythema nodosum leprosum, and in need of such treatment, which comprises administering to the subject an effective amount of an agent having the general structure of Ligand-liniker-Ligand wherein each Ligand has the general formula: in which R is an amine linked to the —O— by an alkylene group; wherein the linker has a linear chain structure of —CH 2 (CH 2 )CH 2 — with y having a value from 3 to 18 and the linker enables formation of a complex with CRP in the presence thereof, wherein the Ligands are the same or different, and bind to CRP by ligand binding sites present on CRP.