Patent ID: 7067526

Claim:
A compound of the formula I or II: wherein n is 1 or 2; R 28 and R 43 are independently selected from the group consisting of H and an aliphatic or acyl moiety; one of R 7a and R 7b is H and the other is halo, —R A , —OR A , —SR A , —OC(O)R A , —OC(O)NR A R B —NR A R B , —NR B C(O)R A , —NR B C(O)OR A , —NR B SO 2 R A , —NR B SO 2 NR A R B′ or —NR B C(O)NR A R B′ ; or R 7a and R 7b taken together, are H in the tetraene moiety: where R A is H or an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety; where R B is H, OH or an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety; where each aliphatic moiety is an independently chosen saturated or unsaturated, branched or unbranched, cyclic or polycyclic, aliphatic hydrocarbon containing 1–8 contiguous aliphatic carbon atoms; where each heteroaliphatic moiety is an independently chosen 2–8-membered non-cyclic or 3–10-membered cyclic aliphatic moiety which contains one or more oxygen, sulfur, nitrogen, phosphorous or silicon atoms; where each aryl moiety is an independently chosen 6–14-membered mono- or polycyclic unsaturated moiety; where each heteroaryl moiety is an independently chosen 5–6-membered monocyclic or 9–14-membered polycyclic unsaturated moiety which contains one or more oxygen, sulfur or nitrogen atoms; and where each acyl moiety is an independently chosen —OCR group where R is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety; or a pharmaceutically acceptable salt thereof.