Patent ID: 7576067

Claim:
A delayed release oral formulation for enhanced intestinal oligonucleotide absorption, comprising: (a) a first population of carrier particles comprising said oligonucleotide and a penetration enhancer, wherein said first population of carrier particles is configured for immediate release of said oligonucleotide and penetration enhancer such that said oligonucleotide and said penetration enhancer are released at a first location in the intestine; and (b) a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix, wherein said second population of carrier particles lacks oligonucleotide, and wherein said second population of carrier particles is configured for delayed release of said penetration enhancer such that said penetration enhancer is released at a second location in said intestine downstream from said first location, whereby absorption of said oligonucleotide is enhanced when said oligonucleotide reaches said second location.