Patent ID: 7601744

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: Z is NR 7 ; R 1 is, independently at each occurrence, alkyl, alkoxy, halo, CF 3 , OCF 3 , arylalkoxy substituted with 0 to 3 R 11 , aryloxy substituted with 0 to 3 R 11 , aryl substituted with 0 to 3 R 11 , heteroaryl substituted with 0 to 3 R 11 , hydroxy, alkanoytoxy, nitro, cyano, alkenyl, alkynyl, alkylsulfoxide, arylsulfoxide substituted with 0 to 3 R 11 , alkylsulfone, arylsulfone substituted with 0 to 3 R 11 , alkylsulfonamide, arylsulfonamide substituted with 0 to 3 R 11 , heteroaryloxy substituted with 0 to 3 R 11 , heteroarylmethoxy substituted with 0-3 R 11 , alkylamido, or arylamido substituted with 0 to 3 R 11 ; or two adjacent R 1 represent methylenedioxy; R 2 is aryl substituted with 0 to 3 R 1 , or heteroaryl substituted with 0 to 3 R 1 ; R 3 is H, F, C 1 to C 4 alkyl, or OR 12 ; R 12 is H or C 1 to C 4 alkyl; R 4 is, independently at each occurrence, H, C 1 to C 4 alkyl, arylalkyl, heteroarylmethyl, cycloheptylmethyl, cyclohexylmethyl, cyclopentylmethyl, or cyclobutylmethyl, or both R 4 groups, together with the nitrogen through which they are attached, form a heterocyclic ring of 4 to 6 ring atoms, where one carbon may be optionally replaced with N, O, S, or SO 2 , and where any carbon ring atom or additional N atom may be optionally substituted with C 1 to C 4 alkyl, F, or CF 3 ; R 7 is H, C 1 to C 6 alkyl, alkenyl, alkynyl, C 3 to C 6 cycloalkyl, aryl substituted with 0 to 3 R 1 , or heteroaryl substituted with 0 to 3 R 1 ; R 8 is H or C 1 to C 4 alkyl; R 9 is H, F, or C 1 to C 4 alkyl; R 10 is, independently at each occurrence, H, or C 1 to C 4 alkyl; or R 10 and R 4 , together with the nitrogen to which R 4 is attached, form a nitrogen-containing ring containing 3 to 6 carbon atoms; n is an integer from 0 to 4; m is an integer from 1 to 2; R 11 is alkyl, alkoxy, halo, CF 3 , OCF 3 , hydroxy, alkanoyloxy, nitro, cyano, alkenyl, alkynyl, alkylsulfoxide, alkylsulfone, alkylsulfonamide, or alkylamido; or two adjacent R 11 also represent methylenedioxy; wherein 1 to 3 carbon atoms in ring A may optionally be replaced with N; and wherein the dotted line between the two R 4 groups represents an optional heterocyclic ring of 4 to 6 ring atoms that may be formed between the two R 4 groups, together with the nitrogen through which they are attached.