Patent ID: 7605170

Claim:
An 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein R 1 is H or C 1-5 alkyl; Y is O or S; m is 1 or 2; n is 0 or 1; Ar 1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar 2 ,said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C 1-5 alkyl, C 1-5 alkoxy, C 3-6 cycloalkyl, C 2-5 alkenyl, C 2-5 alkynl, phenyl, CN and hydroxy, wherein said C 1-5 alkyl and C 1-5 alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar 2 to form a 5-membered ring; Ar 2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C 1-5 alkyl, C 1-5 alkoxy, CN, CONR 2 R 3 , CO 2 R 4 , NHCOR 5 and hydroxy, wherein said C 1-5 alkyl and C 1-5 alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar 1 to form a 5-membered ring; R 2 -R 4 are independently H or C 1-5 alkyl and R 5 is C 1-5 alkyl; or a pharmaceutically acceptable salt thereof.