Patent ID: 7838542

Claim:
A method of relieving osteoporosis in a subject comprising administering a compound of Formula VII: or a salt or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are the same or different and are independently H, C(O)R a , C(O)NR a R b , C(O)OR a , C(O)SR a , OH, OR a , OC(O)R a , OC(O)OR a , NH 2 , NR a R b , NR a C(O)R b , NR a C(O)NR b R c , NR a C(O)OR b , NR a C(O)SR b , NR a S(O)R b , NR a S(O) 2 R b , NR a S(O)OR b , NR a S(O) 2 OR b , NR a P(O)OR b OR c , NR a P(O)OR b R c , NR a P(O)OR b OR c , SR a , S(O)R a , S(O) 2 R a , S(O)OR a , S(O) 2 OR a , S(O)NR a R b , S(O) 2 NR a R b , P(O)OR a OR b , B(OH) 2 , P, halogen, aryl, benzyl, heteroaryl, biaryl, heterobiaryl, heterocycle, or branched, unbranched, or cyclic alkyl; one of R 6 or R 7 is (CH 2 ) t —Z and the remaining R 6 or R 7 is H; Z is aryl, heteroaryl, or biaryl; t is 1; R a , R b , and R c are the same or different and are independently H, aryl, heteroaryl, biaryl, heterobiaryl, or branched, unbranched, or cyclic alkyl; P is SO 3 H, OSO 3 H, OPO 3 H 2 , OPO 3 H 2 , O-lower (C 1 , C 2 , C 3 , C 4 , C 5 , or C 6 ) alkyl-K, O—C(O)-lower (C 1 , C 2 , C 3 , C 4 , C 5 , or C 6 ) alkyl-L, NH-lower (C 1 , C 2 , C 3 , C 4 , C 5 , or C 6 ) alkyl-M, or O-aryl-Q, further wherein lower (C 1 , C 2 , C 3 , C 4 , C 5 , or C 6 ) alkyl is linear or branched alkyl; K is C(O)NH 2 , COOH, SO 3 H, OSO 3 H, PO 3 H 2 , OPO 3 H 2 , NH 2 , NHR 19 , NR 19 R 20 , SO 2 R 21 , glycoside, lower C 1 , C 2 , C 3 , C 4 , C 5 , C 6 alkoxy, or L is aryl, OH, C(O)NH 2 , COOH, SO 3 H, OSO 3 H, PO 3 H 2 , OPO 3 H 2 , NH 2 , NHR 19 , NR 19 R 20 , SO 2 R 21 , glycoside, lower C 1 , C 2 , C 3 , C 4 , C 5 , C 6 alkoxy, or M is aryl, OH, C(O)NH 2 , COOH, SO 3 H, OSO 3 H, PO 3 H 2 , OPO 3 H 2 , NH 2 , NHR 19 , NR 19 R 20 , SO 2 R 21 , glycoside, lower C 1 , C 2 , C 3 , C 4 , C 5 , C 6 alkoxy, or Q is aryl, OH, C(O)NH 2 , COOH, SO 3 H, OSO 3 H, PO 3 H 2 , OPO 3 H 2 , NH 2 , NHR 19 , NR 19 R 20 , SO 2 R 21 , glycoside, lower C 1 , C 2 , C 3 , C 4 , C 5 , C 6 alkoxy, or R 19 , R 20 and R 21 are independently C 1 , C 2 , C 3 , C 4 , C 5 , or C 6 alkyl or R 19 and R 20 taken together with the attached nitrogen atom form a five membered ring; wherein any of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 R a , R b , and R c is substituted or unsubstituted.