Patent ID: 6951918

Claim:
A compound selected from the group of compounds represented by Formula (I): wherein: R 1 and R 4 are, independently or each other, hydrogen or alkyl; R 2 is: (i) cycloalkyl, cycloalkylalkyl, aryl, aralkyl, arykenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocyclo or heterocyloalkyl; or (ii)-(alkylene)-B 1 —X where B 1 is —O—, —NR 8 —, —S(O) n — (where n is 0, 1 or 2), —C═O, —CONR 8 —, —NR 8 SO 2 — or —C(═NR 8 )NR 8 SO 2 — (where R 8 is H or alkyl), and X is cycloalkyl, cycloalkyakyl, aryl, aralkyl heteroaryl or heteroaralkyl; or (iii)-(alkylene)-B 1 —X where B 1 is —NR 8 CO (where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or (iv) R 1 and R 3 form an alkylene or heteroalkylene chain; R 3 is hydrogen or alkyl; R 6 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R 5 is: (i) hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O) X 1 where X 1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NR′R″ (where R′ and R″ are independently H or alkyl, or R′ and R″ form an alkylene chain); or (ii) R 5 and R 4 form an alkylene chain; or (iii) R 5 and R 6 form an alkylene chain; n is 0 or 1; A is —(C═O) CH(R 9 )—(CH 2 ) m N(R 10 )— wherein: m is an integer from 0-5 inclusive; R 9 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)—X 1 where X 1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NR′R″ (where R′ and R″ are independently H or alkyl, or R′ and R″ form an alkylene chain); and R 10 is hydrogen, alkyl, aralkyl or heteroaralkyl; Z is Y—B 2 wherein; Y is alkylene or a bond; and B 2 is —CONR 8 —, —SO 2 , or —SO 2 NR 8 — (where R 8 is hydrogen or alkyl), alkylene (optionally substituted by hydroxy, alkoxy, amino, monoalkylamino, or dialkylamino) or a bond; R 7 is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; provided that when n=0 and Z is SO 2 , then R 2 does not contain an imidazole group; and their pharmaceutically acceptable salts.