Patent ID: 7982024

Claim:
An isolated nucleic acid molecule comprising nucleic acid sequence(s) encoding a monoclonal antibody or an antigen-binding portion thereof that specifically binds to human insulin-like growth factor I receptor (IGF-IR), wherein the heavy chain and the light chain of said antibody comprise the heavy chain CDR1, CDR2 and CDR3 amino acid sequences and the light chain CDR1, CDR2 and CDR3 amino acid sequences, respectively, of an antibody selected from the group consisting of: (a) 2.12.1, which is the antibody produced by the hybridoma deposited under ATCC Accession Number PTA-2792; (b) 2.13.2, which is the antibody produced by the hybridoma deposited under ATCC Accession Number PTA-2788; (c) 2.14.3, which is the antibody produced by the hybridoma deposited under ATCC Accession Number PTA-2790; (d) 3.1.1, which is the antibody produced by the hybridoma deposited under ATCC Accession Number PTA-2791; (e) 4.9.2, which is the antibody produced by the hybridoma deposited under ATCC Accession Number PTA-2789; and (f) 4.17.3, which is the antibody produced by the hybridoma deposited under ATCC Accession Number PTA-2793.