Patent ID: 8076369

Claim:
A method of treating a disorder selected from the group consisting of myelodysplastic syndrome, Parkinson's disease, complex regional pain syndrome, aphthous ulcers, cachexia, graft versus host disease, inflammation of the lungs, depression, atopic dermatitis, diabetic retinopathy, systemic lupus, and multiple sclerosis, in a mammal in need thereof comprising administering to said mammal an effective amount of a compound of formula I: wherein: Y is —C(O)—, —CH 2 —, or —CH 2 C(O)—; R 1 and R 2 are each independently C 1-8 -alkyl, CF 2 H, CF 3 , CH 2 CHF 2 , cycloalkyl, or (C 1-8 -alkyl)cycloalkyl; Z 1 is H, C 1-6 -alkyl, NH 2 , NR 3 R 4 or OR 5 ; Z 2 is H or C(O)R 5 ; X 1 , X 2 , X 3 and X 4 are each independently H, halogen, NO 2 , OR 3 , CF 3 , C 1-6 -alkyl, (C 0-4 -alkyl)-(C 3-6 -cycloalkyl), (C 0-4 -alkyl)-N—(R 8 R 9 ), (C 0-4 -alkyl)-NHC(O)—(R 8 ), (C 0-4 -alkyl)-NHC(O)CH(R 8 )(R 9 ), (C 0-4 -alkyl)-NHC(O)N(R 8 R 9 ), (C 0-4 -alkyl)-NHC(O)O(R 8 ), (C 0-4 -alkyl)-O—R 8 , (C 0-4 -alkyl)-imidazolyl, (C 0-4 -alkyl)-pyrrolyl, (C 0-4 -alkyl)-oxadiazolyl, (C 0-4 -alkyl)-triazolyl or (C 0-4 -alkyl)-heterocycle; R 3 , R 4 , and R 5 are each independently H, C 1-6 -alkyl, O—C 1-6 -alkyl, phenyl, benzyl, or aryl; R 6 and R 7 are independently H or C 1-6 -alkyl; R 8 and R 9 are each independently H, C 1-9 -alkyl, C 3-6 -cycloalkyl, (C 1-6 -alkyl)-(C 3-6 -cycloalkyl), (C 0-6 -alkyl)-N(R 4 R 5 ), (C 1-6 -alkyl)-OR 5 , phenyl, benzyl, aryl, piperidinyl, piperazinyl, pyrrolidinyl, morpholino, or C 3-7 -heterocycloalkyl; or a pharmaceutically acceptable salt thereof or an enantiomer or diastereomer thereof.