Patent ID: 7220414

Claim:
A polymer-drug conjugate comprising a polymer of Formula (I) wherein R and R1 are independently selected from the group consisting of hydrogen, C 1-18 alkyl, C 2-18 alkenyl, C 2-18 alkynyl, C 6-18 aryl, C 7-18 alkaryl and C 7-18 aralkyl groups; X is selected from the groups (IV)–(VIII) wherein R 2 and R 3 are selected from covalent bonds or C 1-18 alkanediyl groups; R 12 are selected from synthetic or natural amino acid side chains; R 4 is selected from the group consisting of hydrogen, activating/protecting groups, and the groups (IX), (X), (XI) and (XII), R 5 and R 6 are selected from the group consisting of —NH 2 , —NHR 13 , —OR 14 ; R 13 and R 14 are selected from activating/protecting groups consisting of N-succinimidyl, pentachlorophenyl, pentafluorophenyl, para-nitrophenyl, dinitrophenyl, N-phthalimido, N-norbonyl, cyanomethyl, pyridyl, trichlorotriazine, 5-chloroquinilino, and protecting groups such as N-(9-fluorenyl-methoxycarbonyl) (Fmcx), carbobenzyloxy (Cbz), 1-(4,4-dimethyl-2,6-dioxocyclohexyldene)-ethyl (Dde) and imidazolyl; and m is an integer of 0-20; wherein X is covalently conjugated to a drug via a peptidic or a hydrolytically-labile bond; Y is —(C n H 2n O) q , C n H 2n- , wherein n is an interger of 2–10 and q is an interger of 1 to 200.