Patent ID: 7345071

Claim:
An improved process for the synthesis of losartan potassium comprising the steps of: (i) reacting approximately equimolar quantities of a potassium salt with trityl losartan in methanol; (ii) refluxing the reaction mixture to obtain a reaction mass comprising losartan potassium; (iii) monitoring the completion of reaction using TLC; (iv) concentrating the reaction mass to approximately 50%; (v) cooling the reaction mass to approximately −5° C.; (vi) distilling out the methanol from the reaction mass; (vii) stripping of methanol from the reaction mass using isopropyl alcohol; (viii) maintaining the reaction mass in secondary alcohol for approximately 12 hours at 25 to 30° C.; (ix) cooling the reaction mass to 0-5° C.; (x) filtering out losartan potassium; (xi) washing with chilled isopropyl alcohol; and (xii) drying the losartan potassium under vaccum.