Patent ID: 7354931

Claim:
A method of treating emphysema in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to formula (I) or a pharmaceutically acceptable salt thereof wherein: n is 1; A is phenyl; B is NR 6 ; R 6 is hydrogen or alkyl; Y is â€”OR 7 ; R 7 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl; Z is â€”C(R 101 ) 2 Oâ€”, â€”R 102 Câ•CR 102 â€”, â€”Câ‰¡Câ€”, â€”C(R 103 ) 2 Sâ€”, â€”C(O)Oâ€” or â€”C(O)NR 10 â€”; each of R 10 , R 101 , R 102 and R 103 is independently hydrogen or alkyl; R 1 and R 2 are independently hydrogen or alkyl; R 3 hydrogen or alkyl; and R 4 and R 5 are independently hydrogen, (C 1 -C 8 ) alkyl or arylalkyl.