Patent ID: 7388094

Claim:
A process for producing a hydroxyl-protected 2′-deoxy-2′-fluorouridine compound represented by formula [4], wherein R represents a hydroxyl-protecting group, by reacting 1-β-D-arabinofuranosyluracil in 3′,5′-hydroxyl-protected form, represented by formula [1], wherein R has the meaning given above, with a trifluoromethanesulfonylating agent represented by formula [2], CF 3 SO 2 X [2] wherein X represents an F atom, Cl atom or CF 3 SO 3 group, in the presence of an organic base, to convert it to a 2′-triflate compound represented by formula [3], wherein R has the meaning given above, and T′ represents a CF 3 SO 2 group, followed by reacting with a fluorinating agent comprising a salt or complex comprising an organic base and hydrofluoric acid.