Patent ID: 8093258

Claim:
A method for inhibiting the activity of urokinase in a patient having a neurodegenerative disease comprising administering to the patient an inhibitory sufficient amount of a urokinase inhibitor of the general formula I in which Ar denotes an aromatic or heteroaromatic ring system, E denotes or Ar and E together form a residue in which Z can be O, NH or C═O and X 4 can be C═O, NH or CH 2 and W can be N, CR 3 or CR 6 and X 5 can be CH, CR 3 , CR 6 or N, B denotes —SO 2 —, —CR 3 2 —, —NR 3 — or —NH—, X 1 denotes NR 13 R 4 , OR 3 , SR 3 , COOR 3 , CONR 3 R 4 or COR 5 , R 1 denotes H, an optionally substituted alkyl, alkenyl, aklinyl, aryl, heteroaryl residue or COOR 3 , CONR 3 R 4 or COR 5 R 2 denotes halogen, C(R 6 ) 3 , C 2 (R 6 ) 5 , OC(R 6 ) 3 or OC 2 (R 6 ) 5 , R 3 denotes H, R 13 denotes a group of the general formula (IIa) or (IIb), X 2 denotes NH, NR 4 , O or S, X 3 denotes NH, NR 4 , O, S, CO, COO, CONH or CONR 4 , Y denotes C(R 8 ) 2 , NH or NR 3 , R 4 denotes-H or a branched or unbranched, optionally substituted alkyl, alkenyl or alkinyl residue, R 5 denotes H, an alkyl, alkenyl, alkinyl, carboxy-alkyl, carboxy-alkenyl, carboxyl-alkinyl, carboxy-aryl, carboxy-heteroaryl, (CO)NR 3 R 6 or —COO—R 3 in which the alkyl, aryl and heteroaryl residues can optionally be substituted, R 6 is in each case independently H or halogen and in particular, R 7 denotes H or a an optionally substituted alkyl, alkenyl, alkinyl, aryl or heteroaryl residue or —COR 9 , R 8 in each case independently denotes H, or a branched or unbranched, optionally substituted alkyl, alkenyl, alkinyl, aryl, heteroaryl, aralkyl, alkylaryl, heteroaralkyl residue or/and a substitute or unsubstituted bicyclic or polycyclic residue, R 9 denotes H or a branched or unbranched, optionally substituted alkyl, alkenyl, alkinyl, aryl or/and heteroaryl residue, R 10 denotes a residue (C(R 1 ) 2 ) o —X 3 R 5 R 11 denotes H[ 1 ] a carbonyl residue —CO—R 12 , B carbonamido residue —CONR 12 , an oxycarbonyl residue —COO—R 12 or particularly preferably a sulfonyl residue —SO 2 R 12 , R 12 denotes H, a branched or unbranched, substituted or unsubstituted alkyl, alkenyl, alkinyl, aryl or heteroaryl residue or a substituted or unsubstituted cyclic alkylresided or a substituted or unsubstituted aralkyl, alkylaryl or heteroaralkyl residue or a substituted or unsubstituted bicyclic or polycyclic residue, R 15 represents C═X 2 , NR 3 or CR 3 2 , n is an integer from 0 to 2, m is an integer from 0 to 5, o is an integer from 1 to 5, or salts of these compounds.