Patent ID: 7842688

Claim:
A compound of the formula (I) where R 1 is substituted or unsubstituted dihydro-2H-benzo[1,4]oxazinyl; R 2 is phenyl substituted by 1-3 halogen, hydroxyl, cyano, trifluoromethyl, C 1-6 -alkyl, halo-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, cyano-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, C 1-6 -alkanoyloxy-C 1-6 -alkyl, C 1-6 -alkoxycarbonyloxy-C 1-6 -alkyl, C 1-6 -alkoxycarbonyl, or C 1-6 -alkoxy groups, or a C 1-6 -alkylenedioxy group, and/or by an L1-T1-L2-T2-L3-T3-L4-T4-L5-U radical; L1, L2, L3, L4 and L5 are each independently a bond, C 1-8 -alkylene, C 2-8 -alkenylene or C 2-8 -alkynylene, or are absent; T1, T2, T3 and T4 are each independently (a) a bond, or are absent, or are one of the groups (b) —CH(OH)— (c) —CH(OR 6 )— (d) —CH(NR 5 R 6 )— (e) —CO— (f) —CR 7 R 8 — (g) —O— or —NR 6 — (h) —S(O) 0-2 — (I) —SO 2 NR 6 — (j) —NR 6 SO 2 — (k) —CONR 6 — (l) —NR 6 CO— (m) —O—CO— (n) —CO—O— (o) —O—CO—O— (p) —O—CO—NR 6 — (q) —N(R 6 )—CO—N(R 6 )— (r) —N(R 6 )—CO—O— (s) pyrrolidinylene, piperidinylene or piperazinylene (t) —C(R 11 )(R 12 )—, where the bonds starting from (b)-(t) lead to a saturated or aromatic carbon atom of the adjacent group if the bond starts from a heteroatom, and where not more than two (b)-(f) groups, three (g)-(h) groups and one (i)-(t) group are present; R 3 is hydroxyl, C 1-6 -alkoxy or C 2-6 -alkenyloxy; R 4 is hydrogen; R 5 and R 6 are each independently hydrogen, C 1-6 -alkyl, C 2-6 -alkenyl, aryl-C 1-6 -alkyl or acyl, or, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered heterocyclic ring which may contain an additional nitrogen, oxygen or sulphur atom or a —SO— or —SO 2 — group, and the additional nitrogen atom may optionally be substituted by C 1-6 -alkyl radicals; R 7 and R 8 , together with the carbon atom to which they are bonded, are a 3-7-membered ring which may contain one or two —O— or —S— atoms or —SO— or —SO 2 — groups; R 9 is hydrogen, C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, acyl or arylalkyl; R 10 is carboxyalkyl, alkoxycarbonylalkyl, alkyl or hydrogen; R 11 is hydrogen or C 1-6 -alkyl; R 12 is hydrogen or C 1-6 -alkyl; U is hydrogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, cyano, optionally substituted C 3-8 -cycloalkyl, aryl, or heterocyclyl; Q is absent; X is a bond, oxygen or sulphur, or is a >CH—R 11 , >CHOR 9 , —O—CO—, >CO, >C═NOR 10 , —O—CHR 11 — or —O—CHR 11 —CO—NR 9 — group and the bond starting from an oxygen or sulphur atom leads to a saturated carbon atom of the Z group or to R 1 ; W is oxygen or sulphur; Z is C 1-6 -alkylene, C 2-6 -alkenylene, hydroxy-C 1-6 -alkylidene, —O—, —S—, —O-alk-, —S-alk-, -alk-O—, -alk-S— or -alk-NR 9 —, where alk is C 1-6 -alkylene; and where (a) if Z is —O— or —S—, X is >CH—R 11 and either R 2 contains an L1-T1-L2-T2-L3-T3-L4-T4-L5-U substituent or R 4 is a substituent other than hydrogen as defined above; (b) if Z is —O-alk- or —S-alk-, X is >CH—R 11 ; and (c) if X is a bond, Z is C 2-6 -alkenylene, -alk-O— or -alk-S—, n is 0 or 1; m is 0; or a pharmaceutically acceptable salt thereof.