Patent ID: 7595202

Claim:
A measurement system including a material A, a material B, a first reporter R 1 , a second reporter R 2 , a material C and a material D for use in a measurement method for a subject material X to be measured, wherein the material A, the first reporter R 1 and the material C are bonded to form a reagent A-R 1 -C; and the material B, the second reporter R 2 , and the material D are bonded to form a reagent B-R 2 -D; the measurement method using a first reagent comprising the material A that specifically bonds to the subject material X to be measured, the material A being labeled with the first reporter R 1 , and a second reagent comprising the material B that specifically bonds to the subject material X to be measured at a different site from that at which the material A bonds, the material B being labeled with the second reporter R 2 that is capable of interacting with the first reporter R 1 , wherein the first reagent includes the material C that bonds to the first reporter R 1 , either the material C or the first reporter R 1 being bonded to the material A to form the first reagent, wherein the second reagent includes the material D that bonds to the second reporter R 2 and has affinity for the material C, the material B and the material D, or the material B and the second reporter R 2 being bonded to form the second reagent, wherein the material A or the material B comprises a material or part thereof selected from the group consisting of antigen, antibody, lectin, lectin-binding carbohydrate, tumor marker, cytokine, cytokine receptor, hormone, hormone receptor, cell adhesion molecule, cell adhesion molecule ligand, nucleic acid, sugar chain, lipid, and hapten, and the material C and the material D are leucine zipper peptides, and the affinity between the material C and the material D is less than both the affinity of the subject material X for the material A and the affinity of the subject material X for the material B, wherein the first reagent, the second reagent, and the subject material X to be measured form a reaction complex, and wherein due to binding based on the affinity in the reaction complex of the material C of the first reagent with the material D of the second reagent, the first reporter R 1 and the second reporter R 2 are stabilized in a spatially proximate state, thereby causing a measurable interaction between the two reporters.