Patent ID: 7727549

Claim:
A method of delivering an otic drug to the ear comprising the steps of (a) preparing an otic composition comprising the otic drug and a carrier, wherein the carrier comprises a low molecular weight compound having a molecular weight of 150-4000, the carrier reversibly changes from solid to liquid at a temperature of 32-37° C., and the low molecular weight compound has the formula: wherein R 1 is —H, —OH, —COOH, C n H 2n+1-2m , COOC n H 2n+1-2m , —COO(CH 2 CH 2 O) n CH 2 CH 2 OH, —CH 2 R 3 , or R 2 , R 3 and R 4 are independently —H, —OH, —COOH, —C n H 2n+1-2m , —OOCC n H 2n+1-2m , —COOC n H 2n+1-2m , —COO(CH 2 CH 2 O) n CH 2 CH 2 OH, —C n H 2n+1-2m COO(CH 2 CH 2 O) n CH 2 CH 2 OH, —OOCC n H 2n+1-2m COOC n′ H 2n′+1-2m′ , —COO − Na + , —COO − K + , —SO 3 H, —SO 3 − Na + , —SO 3 − K + , —NH 2 , —Cl, n, n′ and n″ are independently 0-50; and m, m′ and m″ are independently 0-10, and (b) inserting the composition prepared in step (a) in the ear canal.