Patent ID: 7192976

Claim:
An isolated compound having the structure: tautomer thereof; or a prodrug, salt, hydrate, or ester thereof; wherein X is S; and R is one or more substituents selected from the group consisting of halogen; hydroxy; nitro; CN; aryl; heteroaryl; —C(═O)R a ; —NR b R c ; —S(O) n R d where n —0–2; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen and C 1-6 alkyl; an optionally substituted fused aromatic or non-aromatic 5–6 membered monocyclic ring optionally containing 1–3 heteroatoms selected from the group consisting of N, O, and S; and C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 3-6 cycloalkyl, each independently optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; wherein each occurrence of R 8 is independently selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, aryl, heteroaryl, and NR b R c , wherein C 1-6 alkyl and C 1-6 alkoxy are optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; each occurrence of R b and R c is independently selected from the group consisting of hydrogen; hydroxy; SO 2 R d ; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro and N(R e ) 2; aryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e ) 2 ; and heteroaryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e ) 2 ; each occurrence of R d is independently selected from the group consisting of hydrogen; N(R e ) 2 ; C 1-6 alkyl optionally substatuted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e ) 2 ; aryl and heteroaryl; and each occurrence of R e is independently hydrogen or C 1-6 alkyl.