Patent ID: 8323987

Claim:
A method for screening a plurality of compounds for an ability to bind to a heterodimer of EGFR and another ERBB family member, the method comprising: (a) contacting a first structure comprising an EGFR/ERBB heterodimer with a first solution, the first solution comprising the plurality of compounds, wherein the EGFR/ERBB heterodimer comprises an ERBB family member comprising the amino acid sequence set forth in SEQ ID NO: 6; (b) removing any compounds bound to the first structure to produce a second solution; (c) contacting a second structure comprising an EGFR homodimer with the second solution, wherein the first structure and the second structure are identical except that the second structure does not contain an ERBB family member other than EGFR; and (d) recovering any unbound compounds to produce a third solution, whereby a compound that binds to a heterodimer of EGFR and another ERBB family member is identified.