Patent ID: 6930105

Claim:
A compound of Formula (I): wherein Z is —O—; the bond represented by - - - is a single or double bond; R 1 is H, C 1-8 alkyl, C 3-8 cycloalkyl, or arylC 1-8 alkylene-; each R 2 is independently C 1-8 alkyl, aryl, arylC 1-8 alkylene-, or OR a ; each R 3 is absent or independently H, C 1-8 alkyl, arylC 1-8 alkylene-, provided that each R 3 is absent when the bond represented by - - - is a double bond; each R 4 is independently H, —F, C 1-8 alkyl, aryl, arylC 1-8 alkylene-, heteroaryl, or heteroaryl(C 1-8 )alkylene-; R 5 and R 6 are each independently H, halo, —CN, —NO 2 , —CF 3 , —OCF 3 , azido, —OR a , —NR c R d , —C(═O)NR c R d , —C(═S)NR c R d , C 1-8 alkyl, C 3-8 cycloalkyl, aryl, arylC 1-8 alkylene-, heteroaryl, heteroarylC 1-8 alkylene-, amidinyl, guanidinyl, thioguanidinyl, or cyanoguanidinyl; wherein any aryl or heteroaryl group of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is optionally substituted with up to 4 substituents independently selected from the following: halo, —OH, —CN, —NO 2 , —CF 3 , —OCF 3 , N 3 , —S(O) 0-2 C 1-8 alkyl, —C 1-8 alkyl, —C 3-8 cycloalkyl, —OC 1-8 alkyl, phenyl, —C 1-8 alkanoyl, —C(═O)OR a , —N(R a )C(═O)NR c R d , —N(R a )C(═O)OR a , —C(═O)NR c R d , —C(═S)NR c R d , —SO 2 NR c R d , —C 1-8 alkyl, —NR c R d , —OPh, tetrazolyl, triazolyl, amidinyl, guanidinyl, thioguanidinyl, and cyanoguanidinyl; R a and R b are each independently H, C 1-8 alkyl, —C 3-8 cycloalkyl, aryl, aryl(C 1-8 )alkylene-, heteroaryl, or heteroaryl(C 1-8 )alkylene-; R c and R d are each independently H, C 1-8 alkyl, —C 3-8 cycloalkyl, aryl, aryl(C 1-8 )alkylene-, heteroaryl, or heteroaryl(C 1-8 )alkylene-; or R c and R d together with the nitrogen to which they are attached form a pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, thiomorpholine 1-oxide, or thiomorpholine 1,1-dioxide ring; k is 1 or 2; m is 1; n is 1; p is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; or a pharmaceutically acceptable salt thereof.