Patent ID: 7776882

Claim:
A compound of formula (II) wherein R 1 is selected from the group consisting of hydrogen, C 1-8 alkyl, hydroxy substituted C 2-8 alkyl, NR A R B substituted —C 2-8 alkyl, —C 1-4 alkyl-O—C 1-4 alkyl, cycloalkyl, —(C 1-4 alkyl)-cycloalkyl, heterocycloalkyl and —(C 1-4 alkyl)-(heterocycloalkyl); wherein R A and R B are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; provided that when R 1 is hydroxy substituted C 2-8 alkyl or NR A R B substituted —C 2-8 alkyl, then the hydroxy or NR A R B group is not bound to the alpha carbon; A 1 is selected from the group consisting of —C 1-4 alkyl-; L 1 is selected from the group consisting of —NR C —, —NR C —C(O)— and —C(O)—NR C —; wherein R C is selected from the group consisting of hydrogen, C 1-6 alkyl, hydroxy substituted C 1-4 alkyl and C 5-7 cycloalkyl; R 2 is selected from the group consisting of C 1-8 alkyl, C 2-12 alkenyl, —C 1-4 alkyl-O—C 1-4 alkyl, —C 1-4 alkyl-NR D R E , —C 1-4 alkyl-OH, cycloalkyl, —C 1-4 alkyl-cycloalkyl, partially unsaturated carbocyclyl, —C 1-4 alkyl-(partially unsaturated carbocyclyl), aryl, aralkyl, heteroaryl, —C 1-4 alkyl-heteroaryl, heterocycloalkyl, —C 1-4 alkyl-heterocycloalkyl and —CH(R 3 )—CH 2 —R 4 ; wherein the cycloalkyl, partially unsaturated carbocyclyl, aryl, heteroaryl or heterocycloalkyl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of C 1-4 alkyl, —C 1-4 alkyl-O—C 1-4 alkyl, carboxy, —C(O)O—C 1-4 alkyl and aralkyl; wherein R D and R E are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; wherein R 3 is selected from the group consisting of C 1-4 alkyl-cycloalkyl, —CO 2 H, —C(O)O—C 1-4 alkyl and —C(O)NR F R G ; wherein R F and R G are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; alternatively, R F and R G are taken together with the nitrogen atom to which they are bound to form a 5 to 6 membered heteroaryl or heterocycloalkyl group; wherein R 4 is selected from the group consisting of hydroxy and C 1-4 alkoxy; alternatively, when L 1 is selected from the group consisting of —NR C — and —C(O)—NR C —, R C and R 2 are taken together with the nitrogen atom to which they are bound to form a ring structure selected from the group consisting of 1-piperidinyl, 1-piperazinyl, 4-morpholinyl, 1-pyrrolidinyl, 1-pyrazalidinyl and 1-azepanyl; wherein the piperidinyl, piperazinyl or morpholinyl is optionally substituted with one or more substituents independently selected from C 1-4 alkyl or —C 1-3 alkyl-C(O)—NR J R K ; wherein R J and R K are each independently selected form hydrogen or C 1-4 alkyl; alternatively, R J and R K are taken together with the nitrogen atom to which they are bound to form a heteroaryl or heterocycloalkyl; or a pharmaceutically acceptable salt thereof.