Patent ID: 7312188

Claim:
A compound represented by the general formula (1): wherein A is amino group, or amino group protected with a protecting group which can be degraded in a living body, B 1 and B 2 are each a single bond or alkylene of 1 to 3 carbon atoms optionally substituted with R 4 , in which R 4 is halogen atom; alkyl of 1 to 6 carbon atoms; alkenyl of 2 to 6 carbon atoms; alkynyl of 2 to 6 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; optionally substituted heterocycle; optionally substituted aralkyl; or optionally substituted aryl, and the substituent thereof is alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or aryl, D is a single bond, —NHCO— or NHCO—R 5 —, in which R 5 is alkylene of 1 to 6 carbon atoms; alkenylene of 2 to 6 carbon atoms; alkynylene of 2 to 6 carbon atoms; cycloalkylene of 3 to 7 carbon atoms; optionally substituted heterocycle; optionally substituted aralkylene; or optionally substituted arylene, and the substituent thereof is halogen atom, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or aryl, E is —COOH, a group equivalent to COOH, hydrogen atom, hydroxy group, amino group, halogen atom, or —COOCH 3 , n is an integer of 1 to 3, m is an integer of 1 to 3, G is hydroxy group, amino acid residue, a peptide constructed of 2 to 4 amino acids, or a group represented by the formula in which Z is —NH—, -Asp-Ala-NH—, -Asp-Ala-, —NH-CZ 1 (Z 2 )-, -Asp-NH—, -Asp-NH-CZ 1 (Z 2 )-, or —NH-CZ 1 (Z 2 )-CZ 1 (Z 2 )-, Ring L is a 5- to 10-membered ring optionally containing a heteroatom and/or unsaturated bond, Z 1 and Z 2 are each hydrogen atom, hydroxy group, amino group, cyano group, nitro group, alkyl of 1 to 6 carbon atoms, or halogen atom, X is hydrogen atom, —COOH, a group equivalent to COOH, —CONHR 6 ,—OCH 2 COOR 6 , —OCH 2 CONHR 6 , hydroxy group, —PO 4 H, —SO 3 H, -CZ 1 (Z 2 )-X′ or a group represented by the formula: in which X′ is hydrogen atom, —COOH, a group equivalent to COOH, —CONHR 6 , —OCH 2 COOR 6 , —OCH 2 CONHR 6 , hydroxy group, —PO 4 H, or —SO 3 H, Y and Y′ are each hydrogen atom, —COOH, a group equivalent to COOH, —CONHR 6 , —OR 6 , —PO 4 H, —SO 3 H, halogen atom, or methyl, in which R 6 is an alkyl of 1 to 4 carbon atoms optionally substituted with halogen atom, or hydrogen atom, and k is an integer of 1 to 4, and R 1 , R 2 and R 3 are each —COOH, a group equivalent to COOH, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or alkyl of 1 to 6 carbon atoms substituted with any of phenyl, phenylthio, alkylthio of 1 to 6 carbon atoms, —COOH or heterocycle, provided that the phenyl, phenylthio and heterocycle may be substituted with an alkyl of 1 to 6 carbon atoms, hydroxy group, nitro, a halogen atom, —SO 3 H or —PO 4 H or a pharmaceutically acceptable salt thereof, or a prodrug thereof.