Patent ID: 7307102

Claim:
A method of treating an estrogen-stimulated cancer in a mammal comprising administering to said mammal an amount of a compound of Formula I: wherein R 1 is —(CH 2 ) n CR 5 ═CR 6 R 7 R 2 and R 3 are independently H, —CH 3 , —OH, —OCH 3 , —OCH 2 CH 3 or —CH(CH 3 ) 2 ; R 4 is —CN, —NO 2 , —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 —Y or —Y; R 5 and R 6 are independently H, —C 1-4 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —X—C 1-3 alkyl, —X—C 2-4 alkenyl, —X—C 2-4 alkynyl or —Y; R 7 is —C(O)OR 12 R 12 is H; X is oxygen or sulfur; Y is a halogen; and n is an integer selected from 0, 1 or 2; or pharmaceutically acceptable salt thereof, sufficient to effect said treatment, said cancer being resistant to an estrogen receptor modulator other than said compound of Formula I.