Patent ID: 7259179

Claim:
A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein: D is where X 1 , X 2 , X 3 , X 4 are optionally substituted carbon, or one of X 1 , X 2 , X 3 , X 4 is N; R2 is 0–4 substituents independently chosen from H, halogen, C 1-4 alkyl, CH 2 F, CHF 2 , CF 3 , OCF 3 , aryl, hetaryl, C 1-4 alkylOC 1-4 alkyl, C 1-4 alkylOaryl, C 1-4 alkylNR3R4, CO 2 R3, CONR3R4, CONR3SO 2 R4, NR3R4, C 1-4 alkylNR3R4, nitro, NR3COR4, NR5CONR3R4, NR3SO 2 R4, C 1-4 alkylNR3COR4, C 1-4 alkylNR5CONR3R4, C 1-4 alkylNR3SO2R4; and R3, R4 are each independently H, halogen, CH 2 F, CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkyl cycloalkyl, C 1-4 cyclohetalkyl, aryl, C 1-4 alkyl aryl, hetaryl, C 1-4 alkyl hetaryl, or may be joined to form an optionally substituted 3–8 membered (saturated or unsaturated) ring optionally containing an atom selected from O, S, NR6; and R5 is selected from H, C 1-4 alkyl, halogen, CH 2 F, CHF 2 , CF 3 , aryl or hetaryl; and R6 is selected from H, C 1-4 alkyl, aryl, hetaryl, C 1-4 alkyl aryl, C 1-4 alkyl hetaryl; R1 is H, C 1-4 alkyl, C 1-6 cycloalkyl; Q is a bond, CH 2 , C 1-4 alkyl; A is aryl, hetaryl optionally substituted with 0–3 substituents independently chosen from halogen, C 1-4 alkyl, CH 2 F, CHF 2 , CF 3 , OCF 3 , CN, NR8R9, aryl, hetaryl, C 1-4 aryl, C 1-4 hetaryl, C 1-4 alkylNR8R9, OC 1-4 alkylNR8R9, nitro, NR10C 1-4 NR8R9, NR8COR9, NR10CONR8R9, NR8SO 2 R9, CONR8R9, CO 2 R8 where R8 and R9 are each independently H, C 1-4 alkyl, aryl or which together form an optionally substituted 4–8 membered ring which may contain a heteroatom selected from O, S, NR11, where R11 is C 1-4 alkyl, and R10 is selected from H, C 1-4 alkyl; and W is selected from H, C 1-4 alkyl, C 2-6 alkenyl; where C 1-4 alkyl or C 2-6 alkenyl may be optionally substituted with C 1-4 alkyl, OH, OC 1-4 alkyl, NR12R13; and R12, and R13 are each independently H, C 1-4 alkyl, or may be joined to form an optionally substituted 3–8 membered ring optionally containing an atom selected from O, S, NR14 and R14 is selected from H, C 1-4 alkyl.