Patent ID: 7521194

Claim:
A method of detecting an agent that modulates the activity of CCRL2, the method comprising: (a) contacting a CCRL2 polypeptide comprising the sequence shown in SEQ ID NO: 2 or 4 with a macrophage inflammatory protein-4 (MIP-4) polypeptide comprising the sequence shown in SEQ ID NO: 6 in the presence of a candidate agent under conditions, which in the absence of the candidate agent, permit the binding of the MIP-4 polypeptide to the CCRL2 polypeptide; and (b) monitoring binding of the CCRL2 polypeptide to MIP-4 polypeptide or activity of the CCRL2 polypeptide, wherein if there is a difference between the amount of binding or activity in the absence of the candidate agent and in the presence of it, then said agent is identified as a modulating agent.