Patent ID: 7511146

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable salt or solvate thereof, wherein Y is a bond, â€”(CR 2 R 3 ) p NR 8 (CH 2 ) q â€”, â€”(CR 2 R 3 ) t (CHR 12 )â€”, â€”(CHR 12 ) t (CR 2 R 3 )â€”, â€”CHR 12 CH 2 Nâ€”, â€”CHR 12 CH 2 Sâ€”, â€”CHR 12 CH 2 Oâ€”, â€”C(O)(CR 2 R 3 ) p NR 8 â€”, â€”(CH 2 ) p O(CH 2 ) q â€”, â€”(CH 2 ) p S(CH 2 ) q â€”, â€”(CR 2 R 3 ) t â€”, â€”C(O)(CH 2 ) r Oâ€” or â€”C(O)(CH 2 ) r Sâ€”; m is 1; n is 0, 2 or 3; p is 0 to 4; q is 0 to 4; r is 1 to 3; t is 1 to 6; Ar is aryl, heteroaryl, R 6 -substituted aryl or R 6 -substituted heteroaryl; R 1 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl-, aralkyl, hydroxyalkyl, â€”C(O)R 5 , â€”C(O)OR 5 , â€”C(O)NR 8 R 9 , â€”S(O 2 )R 5 , â€”S(O 2 )NR 8 R 9 , aryl, â€”CF 3 , R 10 -substituted aralkyl, R 10 -substituted aryl, R 10 -substituted alkyl, R 10 -substituted cycloalkyl- or R 10 -substituted cycloalkylalkyl-; R 2 and R 3 can be the same or different, each being independently hydrogen or alkyl; or R 2 and R 3 can be joined together and with the carbon to which they are attached form a 3 to 7-membered ring; R 4 is 1 to 4 substituents, each R 4 is independently selected from the group consisting of hydrogen, â€”OH, alkoxy, â€”OCF 3 , â€”CN, alkyl, halogen, â€”NR 8 C(O)R 7 , â€”C(O)NR 8 R 9 , â€”NR 8 S(O 2 )R 7 , â€”S(O 2 )NR 8 R 9 , â€”S(O 2 )R 7 , â€”C(O)R 7 , â€”C(O)OR 8 , â€”CF 3 , -(alkylene)NR 8 R 9 , -(alkylene)NR 8 C(O)R 7 , CHO, â€”Câ•NOR 8 or two adjacent R 4 groups can be joined together to form a methylene dioxy or ethylene dioxy group; R 5 is alkyl, aryl, aralkyl, cycloalkyl, R 11 -substituted cycloalkyl, or R 11 -substituted aryl; R 6 is 1 to 5 substituents, each R 6 is independently selected from the group consisting of hydrogen, â€”OH, alkoxy, â€”OCH 3 , â€”CN, alkyl, halogen, â€”NR 8 R 9 , â€”NR 8 C(O)R 7 , â€”C(O)NR 8 R 9 , â€”NR 8 S(O 2 )R 7 , â€”S(O 2 )NR 8 R 9 , â€”S(O 2 )R 7 , â€”C(O)R 7 , â€”C(O)OR 8 , â€”CF 3 , â€”(alkylene)NR 8 R 9 , â€”(alkylene)C(O)NR 8 R 9 , â€”(alkylene)NR 8 C(O)R 7 , -(alkylene)NR 8 S(O 2 )R 7 , -(alkylene)NR 8 C(O)NR 8 R 9 , â€”(alkylene)NR 8 C(O)OR 7 , CHO, â€”Câ•NOR 8 and R 7 is alkyl, aryl, aralkyl, or R 11 -substituted aryl; R 8 is hydrogen or alkyl; R 9 is hydrogen, alkyl, aryl, aralkyl, or cycloalkyl; R 10 is 1 to 5 substituents, each R 10 is independently selected from the group consisting of â€”OH, alkoxy, â€”C(O)NR 8 R 9 , â€”NR 8 R 9 , â€”NR 8 S(O 2 )R 5 , â€”NR 8 C(O)NR 8 R 9 , â€”NR 8 C(O)R 5 , â€”NR 8 C(O)OR 5 and â€”C(O)OR 9 ; R 11 is 1 to 5 substituents, each R 11 being independently selected from the group consisting of hydrogen, â€”OH, alkoxy, â€”OCF 3 , â€”CN, alkyl, halogen or â€”CF 3 ; and R 12 is hydroxy or alkoxy.