Patent ID: 7700549

Claim:
A method of treating diabetes in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an exendin agonist peptide analog comprising the amino acid sequence of SEQ ID NO: 3 or a pharmaceutically acceptable salt thereof: (SEQ ID NO:3) X aa1 X aa2 X aa3 Gly Thr X aa4 X aa5 X aa6 X aa7 X aa8 Ser Lys Gln X aa9 Glu Glu Glu Ala Val Arg Leu X aa10 X aa11 X aa12 X aa13 Leu Lys Asn Gly Gly X aa14 Ser Ser Gly Ala X aa15 X aa16 X aa17 X aa18 -Z; Wherein X aa1 is His, Arg or Tyr; X aa2 is Ser, Gly, Ala or Thr; X aa3 is Asp or Glu; X aa4 is Phe, Tyr or naphthylalanine; X aa5 is Thr or Ser; X aa6 is Ser or Thr; X aa7 is Asp or Glu; X aa8 is Leu, lle, Val, pentylglycine or Met; X aa9 is Leu, Ile, pentylglycine, Val or Met; X aa10 is Phe, Tyr or naphthylalanine; X aa11 is Ile, Val, Leu, pentylglycine, tert-butylglycine or Met; X aa12 is Glu or Asp; X aa13 is Trp, Phe, Tyr or naphthylalanine; X aa14 , X aa15 , X aa16 and X aa17 are independently Pro, homoproline, 3Hyp, 4Hyp, thioproline, N-alkylglycine, N-alkylpentylglycine or N-alkylalanine; X aa18 is Ser, Thr or Tyr; and Z is —OH or —NH 2 ; with the proviso that the compound is not exendin-3 or exendin-4.