Patent ID: 8309059

Claim:
A compound of Formula I: or Formula II: wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are each independently H, alkyl, cycloalkyl, aryl, (aryl)alkyl, heteroaryl, amino, hydroxy, halo, sulfo, or -L-R x ; or two adjacent groups of R 1 , R 2 , R 3 , R 4 , R 5 , or R 6 taken together with the atoms to which they are attached form a fused benzo ring that is optionally substituted with 1, 2, 3, or 4 alkyl, cycloalkyl, aryl, (aryl)alkyl, heteroaryl, amino, hydroxy, halo, sulfo, or -L-R x groups; each W 1 and W 2 taken together with the atoms to which it is attached is independently a 5-, 6-, 7-, or 8-membered heterocyclic ring, wherein the ring optionally includes a second heteroatom selected from O, S, or N, wherein the N, if present, is substituted by H, alkyl, (aryl)alkyl, or -L-R x , and wherein at least one carbon atom of W 1 or W 2 is optionally substituted by R 7 ; each Y is independently CR 7 R 7 , S, O, CF 2 , or NR 7 ; each R 7 is independently H, (C 1 -C 8 )alkyl, aryl, (aryl)alkyl, oxo, or -L-R x ; each L is independently a direct bond or a linker, wherein the linker is a divalent radical of the formula -A-B-Z- wherein A is a direct bond or a (C 1 -C 12 )alkyl chain optionally comprising one or more unsaturations, optionally substituted by one or more oxo groups, and optionally interrupted by one or more O atoms; B is a direct bond or a —NHC(═O)—, —C(═O)NH—, —OC(═O)—, —C(═O)O—, —O—, or —N(R 8 )— group; and Z is a direct bond or a (C 1 -C 20 )alkyl chain optionally comprising one or more unsaturations, optionally substituted by one or more oxo groups, and optionally interrupted by one or more O atoms; each R 8 is independently H, (C 1 -C 6 )alkyl, or a nitrogen protecting group; R 9 is -L-R x , —O-Ph-R x , —O-Ph-L-R x ; each R x is independently an activated ester of a carboxylic acid, a maleimide, an amine, an alcohol, a sulfonyl halide, a mercaptan, a boronate, a phosphoramidite, an isocyanate, a haloacetamide, an aldehyde, an azide, an acyl nitrile, a photoactivatable group, a 4-cyanobenzothiazole, a (C 1 -C 8 )alkylhalide, or a sulfo group; provided that at least one -L-R x group is present and provided that at least one R x is not a sulfo group; wherein any alkyl, cycloalkyl, aryl, (aryl)alkyl, or heteroaryl is optionally substituted with one, two, or three halo, hydroxy, or sulfo groups; m is 0 or 1; n is 0, 1, or 2; and an organic or inorganic anion, present when the compound of Formula I or II is cationic.