Patent ID: 7115590

Claim:
A compound of formula (I) wherein: R 1 is hydrogen; C 6-14 aryl; or heteroaryl, optionally substituted with one or more substituents selected from the group consisting of C 1-6 alkoxy, nitro, halogen, amino, hydroxy, carboxy and esters thereof, carboxyalkyl, —CONHR 6 , and —CONR 6 R 7 , wherein R 6 and R 7 , which may be the same or different, are independently selected from C 1-8 alkyl, C 1-8 alkylaryl or C 6-14 aryl; R 2 and R 3 are independently selected from hydrogen or C 1-8 alkyl, C 3-8 cycloalkyl, C 2-8 alkenyl, C 5-8 cycloalkenyl, C 6-14 aryl, or aralkyl wherein each C 1-8 alkyl, C 3-8 cycloalkyl, C 2-8 alkenyl, C 5-8 cycloalkenyl, C 6-14 aryl, or aralkyl may be optionally substituted with one or more substituents selected from the group consisting of C 1-8 alkyl, halo, hydroxy, alkoxy, amino, aminoalkyl, —SH, heterocycle, carboxy and esters thereof, carboxyalkyl, —CONHR 6 , and —CONR 6 R 7 , wherein R 6 and R 7 , which may be the same or different, are independently selected from C 1-8 alkyl, C 1-8 alkylaryl or C 6-14 aryl; or R 2 and R 3 can together with the C atom to which these are attached form a 3 to 8-membered ring, wherin the ring members are C atoms; R 4 is —OR 8 , —NR 8 R 9 or —SR 8 , where R 8 and R 9 , which may be the same or different, are independently selected from hydrogen; or C 1-8 alkyl, C 3-8 cycloalkyl, C 2-8 alkenyl, C 5-8 cycloalkenyl, aralkyl, heteroaryl, or C 6-14 aryl wherein each C 1-8 alkyl, C 3-8 cycloalkyl, C 2-8 alkenyl, C 5-8 cycloalkenyl, aralkyl, heteroaryl, or C 6-14 aryl may be optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, alkoxy, amino, aminoalkyl, —SH, carboxy and esters thereof, carboxyalkyl, —CONHR 6 , and —CONR 6 R 7 , wherein R 6 and R 7 , which may be the same or different, are independently selected from C 1-8 alkyl, C 1-8 alkylaryl or C 6-14 aryl; R 5 is hydrogen; C 1-8 alkyl; or C 6-14 aryl; or R 2 and R 5 may together with the C atom and the N atom to which these are respectively attached form a 5- or 6-membered ring wherein the ring members contributed by R 2 /R 5 are C atoms or R 3 and R 5 may together with the C atom and N atom to which these are respectively attached form a 5- or 6-membered ring wherein the ring members contributed by R 2 /R 5 are C atoms; or a pharmaceutically acceptable salt, ester or salt of an ester of the compound of formula (I).