Patent ID: 7256024

Claim:
A process for the preparation of tyrissamycin having the following characteristics: (a) a white amorphous powder; (b) soluble in chloroform, dimethylsulfoxide and methanol, and essentially insoluble in water; (c) has an ultraviolet absorption spectrum when dissolved in methanol substantially as shown in FIG. 1 ; (d) has an infrared absorption spectrum (KBr) substantially as shown in FIG. 2 ; (e) has a proton magnetic resonance spectrum in CD 3 OD substantially as shown in FIG. 3 ; and (f) has a 13 C magnetic resonance spectrum in CD 3 OD substantially as shown in FIG. 4 ; which comprises cultivating Streptomyces lividans ATCC-202143 under submerged aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen until a substantial amount of tyrissamycin is produced by said organism in said culture medium.