Patent ID: 7118856

Claim:
A method for screening a library for identifying an active enantiomer of a chiral drug candidate having activity with respect to an L-protein, wherein the activity is selected from the group consisting of inhibition and binding, the method comprising the following steps: Step A: providing a D-protein, the D-protein being an enantiomer of the L-protein, and a chemical library comprising chiral compounds; Step B: contacting one or more compounds from the library under suitable conditions with the D-protein of said Step A and identifying at least one compound having activity to said D-protein; Step C: providing one or more enantiomer compounds of said at least one compound identified in Step B, and contacting said L-protein with said one or more said enantiomer compounds; and Step D: identifying at least one enantiomer compound provided in Step C that binds to said L-protein in order to verify the activity of said enantiomer compound that binds to said L-protein.