Patent ID: 8703147

Claim:
A composition comprising: (a) at least one immunogenic erythrocyte binding antigen (EBA) molecule of an EBA protein of a strain of Plasmodium falciparum , the EBA molecule consisting of an amino acid sequence selected from the group consisting of: (i) the amino acid sequence of residue 746 to residue 1045 of SEQ ID NO: 9, (ii) the amino acid sequence of residue 761 to residue 1271 of SEQ ID NO: 5, and (iii) the amino acid sequence of residue 755 to residue 1339 of SEQ ID NO: 7, and (b) at least one immunogenic reticulocyte-binding protein homologue (Rh) molecule comprising a contiguous amino acid sequence of a Rh protein of a strain of Plasmodium falciparum selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 13, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51 and SEQ ID NO: 52, wherein when administered to a subject the composition induces an invasion-inhibitory immune response to the strain, wherein said composition is substantially free from other proteins of Plasmodium.