Patent ID: 7655797

Claim:
A process for preparing a compound of formula (I): comprising contacting a compound of formula (II): or a salt or N-oxide thereof, with 2,4-dichloro-5-fluoropyrimidine under conditions to provide for the compound of formula (I); wherein Y is selected from the group consisting of O, S, SO, SO 2 , S(O)NR 36 , and NR 35 ; Z is selected from the group consisting of O, S, SO, SO 2 , S(O)NR 36 , and NR 35 ; each R 35 , independently of the others, is selected from the group consisting of hydrogen and R 8 , or, alternatively, two R 35 bonded to the same carbon atom are taken together to form an oxo (═O) group; each R 36 , independently, is selected from the group consisting of hydrogen and R 8 ; each R 8 , independently, is selected from the group consisting of R a , R b , R a substituted with one or more of the same or different R a or R b , —OR a substituted with one or more of the same or different R a or R b , —B(OR a ) 2 , —B(NR c R c ) 2 , —(CH 2 ) m —R b , —(CHR a ) m —R b , —O—(CH s ) m —R b , —S—(CH 2 ) m —R b , —O—CHR a R b , —O—CR a (R b ) 2 , —O—(CHR a ) m —R b , —O—(CH s ) m —CH[(CH 2 ) m R b ]R b , —S—(CHR a ) m R b , —C(O)NH—(CH 2 ) m R b , —C(O)NH—(CHR a ) m R b , —O—(CH 2 ) m —C(O)NH—(CH 2 ) m R b , —S—(CH 2 ) m —C(O)NH—(CH 2 ) m —R b , —O—(CH 2 ) m —C(O)NH—(CH 2 ) m —R b , —S—(CH 2 ) m —C(O)NH—(CH 2 ) m —R b , —NH—(CHR a ) m —R b , —NH[(CH 2 ) m R b ], —N[(CH 2 ) m R b ] 2 , —NH—C(O)—NH—(CH 2 ) m —R b , —NH—C(O)—(CH 2 ) m CHR b R b and —NH—(CH 2 ) m —C(O)—NH—(CH 2 ) m —R b ; each R a , independently, is selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 3 -C 8 ) cycloalkyl, (C 4 -C 11 ) cycloalkylalkyl, (C5-C10) aryl, (C6-C16) arylalkyl, 2-6 membered heteroalkyl, 3-8 membered cycloheteroalkyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl and 6-16 membered heteroarylalkyl; each R b , independently, is selected from the group consisting of —OR d , (C 1 -C 3 ) haloalkyloxy, —SR d , —NC c R c , halogen, —CF 3 , —CN, —NC, —OCN, —SCN, —NO, —NO 2 , —N 3 , —S(O)R d , —S(O) 2 R d , —S(O) 2 OR d , —S(O)NR c R c , —S(O) 2 NR c R c , —OS(O)R d , —OS(O) 2 R d , —OS(O) 2 OR d , —OS(O) 2 NR c R c , —C(O)R d , —C(O)OR d , —C(O)NR c R c , —C(NH)NR c R c , —C(NR a )NR c R c , —C(NOH)R a , —C(NOH)NRCRC, —OC(O)R d , —OC(O)OR d , —OC(O)NR c R c , —OC(NR a )NR c R c , —OC(NR a )NR c R c , —[NHC(O)] n R d , —[NR a C(O)] n R d , —[NHC(O)] n OR d , —[NR a C(O)] n OR d , —[NHC(O)] n NR c R c , —[NR a C(O)] n NR c R c , —[NHC(NH)] n NR c R c and —[NR a C(NR a )] n NR c R c , each R c , independently, is R a , or alternatively, two R c , each taken together with the nitrogen atom to which it is bonded, form a 5 to 8-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the same or different additional heteroatoms and which may optionally be substituted with one or more of the same or different R a or R b groups; each R d independently is R a ; each m independently is an integer from 1 to 3; and each n independently is an integer from 0 to 3.