Patent ID: 8003692

Claim:
A method of treating intestinal fluid loss in a subject, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof wherein a therapeutically effective amount of a compound reduces cyclic adenosine monophosphate levels, and wherein the formula of the compound is selected from the group consisting of: and any combination thereof wherein, R is an optionally substituted cyclic or bicyclic ring structure; wherein R is selected from the group consisting of phenyl, pyranyl, pyridyl, imidazolyl, 1,8-naphthridinyl and N-oxide pyridyl X is an alkyl, oxygen, an ester, an amine, or an amide Z is selected from the group consisting of hydrogen, alkenyl, alkynyl, phenyl, benzyl, halo, fluoro, chloro, bromo, iodo, hydroxy, keto, oxo, aldo, carbonate, carboxy, alkoxy, ester, carboxamido, amino, ammonio, imino, imido, azido, azo, cyanato, isocyano, isocyanato, isothiocyanato, nitroxy, cyano, nitrosooxy, nitro, nitroso, 4-pyridyl, 3-pyridyl, 2-pyridyl, thioether, sulfonyl, sulfo, sulfinyl, mercapto, sulfanyl, sulfhydryl, sulfonamino, thiocyanato, alkyl amino, hydroxyamic acid, methyl, ethyl, 1,3-dioxylanyl, propyl, iso-propyl, butyl, tert-butyl, alkyl, (C1-C3) alkenyl, aryl, alkylaryl; W is selected from the group consisting of CO, NH, methylene, sulfur atom, oxygen atom and thionyl; and, n is 0 or 1 wherein the intestinal fluid loss is the result of a bacterial infection of a pathogen, wherein the pathogen is selected from a group consisting of B. antracis, V. cholerae, E. coli, S. typhimurium, Y. pestis and any combination thereof.