Patent ID: 7572917

Claim:
A method for preparing a compound having Formula (S 3 ) as follows said method comprising condensing a disilyloxydiene of Formula (II) with an aldehyde having Formula (Q 3 ) as follows in the presence of a titanium (IV) catalyst having Formula (IV) in an inert solvent to obtain a 5(S)-hydroxy-3-ketoester having Formula (S 3 ), wherein R 1 is optionally substituted alkyl, cycloalkyl or aralkyl; R 2 , R 3 and R 4 are, independently, hydrogen, halogen, hydroxy, optionally substituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaralkyl, optionally substituted alkoxy, aryloxy, aralkoxy, heterocyclooxy or heteroaralkoxy; R 8 is a lower alkyl; the binaphthyl moiety is in the S-configuration; and R and R′ are, independently, a lower alkyl.