Patent ID: 7009053

Claim:
A quinoline derivative of formula 1 or its pharmaceutically acceptable salt: wherein R 2 is H; halogen; C 1-6 alkyl; C 1-6 alkoxy; C 1-6 alkoxyalkyl; or C 3-6 cycloalkyl; R 1 is —CN; or wherein Y is O; N; or S; A is H; C 3-6 alkenyl unsubstituted or substituted by C 1-3 alkyl; C 3-6 cycloalkyl; C 6-14 aryl unsubstituted or substituted by halogen, C 1-6 alkyl or C 1-6 alkoxy; C 1-6 alkoxyalkyl; or C 1-6 alkyl unsubstituted or substituted by C 6-14 aryl or 5–15 membered heteroaryl wherein aryl group can be unsubstituted or substituted by halogen, C 1-6 alkyl, C 1-6 halogenoalkyl, C 1-6 alkoxy or amino group; R 3 is H; halogen; unsubstituted or substituted amino; C 1-6 alkyl; C 1-6 alkoxy; C 1-6 alkoxyalkyl; or C 3-6 cycloalkyl; n is 0, 1, 2 or 3; R is H; C 6-14 aryl unsubstitued or substituted by halogen, C 1-6 alkyl, C 1-6 alkoxy or amino; 5–15 membered heterocyclic group unsubstituted or substituted by halogen, C 1-6 alkyl, C 1-6 alkoxy or amino; or —(CH 2 ) n —CHR 4 R 5 wherein n is 0, 1, 2, 3 or 4; R 4 is H; C 1-6 alkyl; C 1-6 alkoxy; C 6-14 aryl unsubstitued or substituted by halogen, C 1-6 alkyl, C 1-6 halogenoalkyl, C 1-6 alkoxy or amino; 5–15 membered heteroaryl; C 3-6 cycloalkyl; 5–15 membered heterocyclic group unsubstituted or substituted by C 1-6 alkyl; or 5–15 membered C 6-14 aryl fused to heterocyclic group; R 5 is H; C 1-6 alkyl; C 1-6 alkoxy; or C 1-6 alkoxyalkyl.