Patent ID: 8461191

Claim:
A method of treating cancer, comprising the step of administering to a patient in need thereof a therapeutically effective amount of a compound of formula 1: or a pharmaceutically acceptable salt thereof; wherein independently for each occurrence; n is 0; R 1 is H R 2 and R 3 independently for each occurrence are H, alkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroaralkyl, or —[C(R 5 )(R 6 )] p -R 4 ; or has the formula 1a: wherein m is 0, 1, 2, or 3; R 7 for each occurrence independently is H, alkyl, aryl, alkenyl, halide, hydroxyl, alkoxyl, alkenyloxy, aryloxy, acyloxy, amino, alkylamino, arylamino, acylamino, aralkylamino, nitro, acylthio, carboxamide, carboxyl, nitrile, —OSO 3 R 5 , —SO 2 R 5 , —S(O)R 5 , —SR 5 , —PO 2 OR 5 , —OPO 2 OR 5 , —COR 5 , —CO 2 R 5 , —OCH 2 CO 2 R 5 , or —OCH 2 C(O)N(R 5 )(R 6 ); or two occurrences of R 7 taken together may form a monocyclic ring between 5-8 ring atoms, of which, one, two, or three atoms are independently S, O, or N; R 4 is amino, alkylamino, arylamino, acylamino or aralkylamino; each of R 5 and R 6 independently for each occurrence is H, alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroaralkyl; and wherein the cancer is selected from the group consisting of chronic lymphocytic leukemia, non-Hodgkin's lymphoma multiple myeloma, Waldenstrom's macroglobulinemia, mesothelioma, prostate cancer, small cell lung cancer, melanoma, follicular lymphoma, and diffuse large B-cell lymphoma.