Patent ID: 7915253

Claim:
A compound having structural Formula (I) Or a pharmaceutically acceptable salt, or ester thereof, wherein; A is a saturated or unsaturated hydrocarbon chain having from 3 to 5 atoms, forming a five- to seven-membered ring; T is selected from the group consisting of —C(O)OH, —C(O)NH 2 , and tetrazole; G 1 is selected from the group consisting of —(CR 1 R 2 ) n —, —Z(CR 1 R 2 ) n —, —(CR 1 R 2 ) n Z—, —(CR 1 R 2 ) r Z(CR 1 R 2 ) s —; Z is O, S or NR; n is 0, 1, or 2; r and s are independently 0 or 1; R 1 and R 2 are independently selected from the group consisting of hydrogen, halo, optionally substituted lower alkyl, optionally substituted lower heteroalkyl, optionally substituted lower alkoxy, and lower perhaloalkyl or together may form an optionally substituted cycloalkyl; X 1 , X 2 , and X 3 are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, halogen, perhaloalkyl, hydroxy, optionally substituted lower alkoxy, nitro, cyano, and NH 2 ; G 2 is selected from the group consisting of a saturated or unsaturated heterocycloalkyl linker, optionally substituted with X 4 and X 5 ; X 4 and X 5 are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, halogen, lower perhaloalkyl, hydroxy, optionally substituted lower alkoxy, nitro, cyano, NH 2 , and CO 2 R, or X 4 and X 5 together may form a carbocycle; R is selected from the group consisting of optionally substituted lower alkyl and hydrogen; G 3 is selected from the group consisting of a bond, a double bond, —(CR 3 R 4 ) m —, carbonyl, and —(CR 3 R 4 ) m CR 3 ═CR 4 —; m is 0, 1, or 2; R 3 and R 4 are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted aryl, lower perhaloalkyl, cyano, and nitro; G 4 is selected from the group consisting of hydrogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted cycloheteroalkyl, optionally substituted cycloheteroaryl, optionally substituted cycloalkenyl, and —N═(CR 5 R 6 ); and R 5 and R 6 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, and optionally substituted cycloheteroalkyl.