Patent ID: 7795253

Claim:
A compound of the formula in which R is deuterium, halogen, or hydrogen; R 1 is aryl-C 0 -C 4 -alkyl or heterocyclyl-C 0 -C 4 -alkyl, which radicals are unsubstituted or substituted by 1-4 C 1 -C 8 alkoxy, C 1 -C 8 alkoxycarbonyl, C 1 -C 8 alkyl, C 0 -C 8 alkylcarbonyl, C 1 -C 8 alkylsulphonyl, unsubstituted or substituted aryl, aryl-C 0 -C 4 alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, hydroxy, nitro, oxide, oxo, tri-C 1 -C 4 alkylsilyl, trifluoromethoxy or trifluoromethyl, wherein the heterocyclyl of the heterocyclyl-C 0 -C 4 -alkyl stands for a saturated, partially saturated or unsaturated, 4-8-membered monocyclic ring system, or a saturated, partially saturated or unsaturated, 7-12-membered bicyclic ring system, or a partially saturated or unsaturated, 9-12-membered tricyclic ring system which comprises an N, O or S atom in at least one of the rings, it being possible for an additional N, O or S atom to be present in one ring; R 2 is a) deuterium, halogen, hydroxy, cyano or hydrogen; or b) C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 alkoxy, C 1 -C 4 alkoxycarbonyl-C 1 -C 4 alkyl, C 1 -C 8 alkyl, C 0 -C 4 alkylcarbonyl, aryl-C 0 -C 4 alkyl, carboxy-C 1 -C 4 alkyl, C 3 -C 8 cycloalkyl or heterocyclyl-C 0 -C 4 alkyl, which radicals are unsubstituted or substituted by 1-4 C 1 -C 8 alkoxy, C 1 -C 8 alkoxycarbonyl, C 1 -C 8 alkyl, C 0 -C 8 alkylcarbonyl, C 1 -C 8 alkylsulphonyl, unsubstituted or substituted aryl, aryl-C 0 -C 4 alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, hydroxy, nitro, oxide, oxo, tri-C 1 -C 4 alkylsilyl, trifluoromethoxy or trifluoromethyl; R 3 is C 1 -C 8 alkyl; Q is oxygen; m is a number 0, 1 or 2; n is 1; or a pharmaceutically acceptable salt thereof, where R 1 is not C 1 -C 8 alkyl-substituted aryl if R 2 is hydrogen, and which compound shows an aromatase inhibitory activity at least 10 times higher, than the compound of the formula (I) with the opposite configuration around the asymmetric carbon atom labelled “*”.