Patent ID: 6852747

Claim:
A method of lightening skin in a human, comprising administering to said human a skin-lightening effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R is a (C 3 -C 8 )cycloalkyl ring substituted by one of —N(R 1 )SO 2 (CHR 1 ) n R 2 or —(C 1 -C 6 )alkylN(R 1 )SO 2 (CHR 1 ) n R 2 , wherein each R 1 is independently selected from hydrogen or (C 1 -C 6 )alkyl, R 2 is phenyl or naphthyl optionally substituted with one or more substituents independently selected from halogen, OH, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkoxy, trifluoromethoxy, —S(O) m (C 1 -C 6 )alkyl, amino, —N(R 1 )CO(C 1 -C 6 )alkyl, COOR 1 , —(C 1 -C 6 )alkylCOOR 1 , —CO(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, —(C 1 -C 6 )alkylamino, di-((C 1 -C 6 )alkyl)amino, nitro, cyano, —CONH(CHR 1 ) n CO 2 R 1 , —CONR 1 N(R 1 ) 2 , trifluoromethyl, aryl, heteroaryl, and heterocycloalkyl; n is an integer from 0 to 6; and m is an integer from 0 to 2.