Patent ID: 7060836

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt, prodrug, solvate or polymorph thereof, wherein: R is het a ; R 1 is phenyl optionally substituted by one or more substituents independently selected from halogen, C 1-6 alkoxy optionally substituted by one or more halogen, and C 1-6 alkyl optionally substituted by one or more halogen; m is 1–4; Z is selected from: a) N(R 3 ) (R 4 X) wherein X is NR 3 R 5 , OR 3 , Oaryl 1 , Ohet b , Ohet c , aryl 1 , het b or het c ; b) N(R 3 )Y wherein Y is aryl 1 , het b or het c ; and c) a 4–7 membered N containing saturated or partially saturated heterocycle said heterocycle attached to the alkylene link via said nitrogen atom, said heterocycle optionally containing an additional 1–3 groups, each independently selected from C═O, NH, S(O) p and O; optionally, said heterocycle is: (i) spirofused with het b , such that both rings share 1 atom; or (ii) substituted by 1–3 groups each independently selected from het b , het c , aryl 1 , R 3 , R 4 OR 3 , R 4 C(O)R 3 , OR 3 , OR 7 OR 3 , OR 4 OC(O)R 3 , OR 4 OC(O)NR 3 R 6 , S(O) p R 4 , C(O)R 3 , C(O)NR 3 R 6 , C(O)OR 3 , R 7 C(O)OR 3 , C(O)R 7 OR 3 , C(O)OR 7 OR 3 , CF 3 , NR 3 R 6 , R 4 NR 3 R 5 , OC(O)NR 3 R 4 and NR 3 R 5 ; wherein R 3 and R 6 are both independently selected from H and C 1-6 alkyl; wherein R 4 and R 7 are both independently selected from C 1-6 alkylene; wherein R 5 is selected from C(O)OR 3 , S(O) p R 3 , S(O) p aryl 1 , C(O)R 3 , and C(O)NR 3 R 6 ; het b is a 4–7 membered heterocycle containing 1–3 heteroatoms, each independently selected from N, O and S, said N being optionally substituted with O, said ring optionally containing 1–2 C═O groups, said ring being saturated or partially saturated, said ring being optionally benzofused, said ring being optionally substituted by 1–3 substituents selected from halo, R 3 , OR 3 , C(O)NR 3 R 6 , R 7 NR 3 R 6 , NR 3 R 5 , NHS(O) p R 4 , S(O) p NR 3 R 6 , S(O) p R 4 , CN, NR 3 R 6 and aryl 1 ; het a and het c independently represent a 5–7 membered aromatic heterocycle containing 1–3 heteroatoms each independently selected from N, O and S, said ring being optionally benzofused, said ring system as a whole being optionally substituted by 1–3 substituents, each independently selected from: halo, R 3 , OR 3 , C(O)NR 3 R 6 , R 4 NR 3 R 6 , NR 3 R 5 , NHS(O) p R 4 , S(O) p NR 3 R 6 , S(O) p R 4 , CN, NR 3 R 6 and R 4 NR 3 S(O) p R 3 ; aryl 1 is phenyl or naphthyl, each optionally substituted by 1–3 substituents, each independently selected from: halo, R 3 , OR 3 , C(O)NR 3 R 6 , R 7 NR 3 R 6 , NR 3 R 5 , NHS(O) p R 4 , S(O) p NR 3 R 6 , S(O) p R 4 , CN; p is 0, 1 or 2; and n is 2.