Patent ID: 7030118

Claim:
A compound having formula I or its enantiomer, diastereomer, or pharmaceutically acceptable salt thereof, wherein: Y 1 , Y 2 , and Y 3 are independently H, halogen, —CN, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, —OR 6 , —NR 7 R 8 , —C(═O)R 9 , —C(═O)OR 10 , —C(═O)NR 11 R 12 , —OC(═O)OR 10 , —OC(═O)NR 11 , R 12 , —NR 13 C(═O)OR 10 , —NR 13 C(═O)NR 11 R 12 , —SO 2 R 9 , —SO 2 NR 11 R 12 , —NR 13 SO 2 NR 11 R 12 ; Z is O or S; R 1 is H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarylalkyl, or substituted heteroarylalkyl; R 2 and R 3 are independently H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms; n=1 to 4; A is O, S or N with the proviso that when A is O or S, R 5 is nonexistent; R 4 and R 5 are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, C(═O)R 9 , C(═O)OR 10 , C(═O)NR 11 R 12 , SO 2 R 9 , SO 2 NR 11 R 12 , or in the case of A being N, taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms; R 6 , R 7 , and R 8 are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, —C(═O)H, —C(═O)alkyl, —C(═O)substituted alkyl, —C(═O)alkenyl, —C(═O)substituted alkenyl, —C(═O)alkynyl, —C(═O)substituted alkynyl, —C(═O)aryl, —C(═O)substituted aryl, —C(═O)heteroaryl, —C(═O)substituted heteroaryl, or R 7 and R 8 may be taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms; R 9 , R 10 , R 11 , R 12 , R 13 are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or R 11 and R 12 may be taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms.