Patent ID: 8552139

Claim:
A composition comprising at least two different polymers, wherein each polymer is independently selected from: a biodegradable polyester of formula III, VI, or XI, or a pharmaceutically acceptable salt thereof: (A) —[(X) a —O—R 1 —O—(Y) b —(Y 1 ) c —R 2 —(X 1 ) d ] m — III wherein the polyester of formula III is formed by condensation polymerization of monomers of formula I and II: H—(X) a —O—R 1 —O—(Y) b —H I R 3 —(Y 1 ) c —R 2 —(X 1 ) d —R 4 II B —[(Y 2 ) a —R 5 —(X 2 ) b —(X 1 ) c —O(O═)C—R 8 —C(═O)O—(Y 1 ) d ] n — VI wherein the polyester of formula IV is formed by condensation polymerization of monomers of formula IV and V: R 6 —(Y 2 ) a —R 5 —(X 2 ) b —R 7 IV H—(X 1 ) c —O(O═)C—R 8 —C(═O)O—(Y 1 ) d —H V (E) —[(Y) e —R 13 —C(═O)O—(Y) f ] g — XI wherein the polyester of formula XI is formed by self condensation polymerization of a monomer of formula X: R 14 —(Y) e —R 13 —C(═O)O—(Y) f —H X wherein: m, n, and q are each independently an integer from about 5 to about 1000; R 1 , R 5 , and R 13 are each independently the remaining portion of a biologically active compound; R 2 and R 8 are each independently the remaining portion of a biologically active compound or non-biologically active compound; R 3 , R 4 , R 6 , R 7 , and R 14 are each independently selected from Cl, F, Br, and I; X, X 1 , and X 2 are independently at each occurrence —OC(═O)CH 2 — (inverse glycolic acid moiety), —OC(═O)CH(CH 3 )— (inverse lactic acid moiety), —OC(═O)CH 2 OCH 2 CH 2 — (inverse dioxanone acid moiety), —OC(═O)CH 2 CH 2 CH 2 CH 2 CH 2 — (inverse caprolactone acid moiety), —OC(═O)(CH 2 ) y —, or —OC(═O)(OCH 2 CH 2 ) z —: Y, Y 1 , and Y 2 are independently at each occurrence —CH 2 C(═O)O— (glycolic acid moiety), —CH(CH 3 )C(═O)O— (lactic acid moiety), —CH 2 CH 2 OCH 2 C(═O)O— (dioxanone moiety), —CH 2 CH 2 CH 2 CH 2 CH 2 C(═O)O— (caprolactone moiety), —(CH 2 ) y C(═O)O—, or —(CH 2 CH 2 O) z CH 2 C(═O)O—; each y and z is independently an integer from about 2 to about 24; each a, b, c, and d is independently an integer from about 1 to about 6; each e is independently an integer from about 1 to about 6; and each f is independently an integer from about 0 to about 6.