Patent ID: 8372836

Claim:
A solid dispersion, comprising: (a) a poorly water soluble ionizable drug, the neutral form of said drug having (i) a solubility of less than 1 mg/mL in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5; (b) a cationic species; and (c) a dispersion polymer wherein said drug is not 6-amino-9-benzyl-8-oxo-8,9-di hydro-7H-purine-2-carboxylic acid cyclopropylmethyl-amide, at least 90 wt % of said drug in said solid dispersion is in a non-crystalline form and said drug, said cationic species, and said dispersion polymer constitute at least 80 wt % of said solid dispersion, wherein said dispersion polymer is selected from the group consisting of hydroxypropyl methylcellulose, hydroxypropyl methylcellulose acetate, hydroxypropyl cellulose, poloxamers, neutralized forms of hydroxypropyl methylcellulose acetate succinate, neutralized forms of hydroxypropyl methylcellulose phthalate, neutralized forms of cellulose acetate phthalate, neutralized forms of cellulose acetate trimellitate, neutralized forms of carboxymethyl ethyl cellulose, and mixtures thereof.