Patent ID: 8110218

Claim:
A pharmaceutical composition comprising lipidic structures, wherein the lipidic structures comprise: a. phosphatidylethanolamine (PE) derivatized with polyethylene glycol (PEG) (PEG-derivatized PE); b. an amphipathic lipid selected from the group consisting of phosphatidylcholine (PC), phosphatidylglycerol (PG), and combinations thereof, and, optionally, PE; c. a negatively charged lipid selected from the group consisting of phosphatidylserine (PS), phosphatidic acid (PA) and combinations thereof; and d. Factor VIII, wherein the ratio of amphipathic lipid to the negatively charged lipid is between 50:50 to 90:10 and the amount of PEG derivatized PE is from 1-15 mole %, and wherein the immunogenicity of Factor VIII is reduced over the immunogenicity of free Factor VIII.