Patent ID: 8754211

Claim:
A compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof: wherein is selected from the group consisting of monocyclic aryl or monocyclic heteroaryl; W is selected from the group consisting of a direct bond, —O—, and —N(R 6 )—; provided that if W is a direct bond, D is a cyclic amine that is attached to A via the nitrogen atom of the cyclic amine; D is selected from the group consisting of a direct bond, unsubstituted C 1 to C 4 alkyl, unsubstituted C 3 to C 7 cycloalkyl, cycloalkyl, a 4- to 6-membered cyclic amine, substituted C 1 to C 4 alkyl with R 2a , R 2b , and R 2c , and substituted C 3 to C 7 cycloalkyl with R 2a , R 2b , and R 2c ; E and G are independently N or CH provided that both are not N and both are not CH; R 1 is substituted or unsubstituted phenyl or substituted or unsubstituted monocyclic heteroaryl; R 2a , R 2b , and R 2c are independently selected from the group consisting of hydrogen, halo, cyano, hydroxyl, —NR 5 R 5a , —SO 2 R 34 , —CO 2 R 35 —NR 5 CO 2 R 21 , —NR 5 COR 21 , substituted or unsubstituted C 1 to C 4 alkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, substituted or unsubstituted 4- to 6-membered cyclic amines wherein said cyclic amine is optionally substituted with —OH, carbonylamino, alkoxycarbonylamino, or any two of R 2a , R b , or R 2c , may be taken together to form a ring; R 3 and R 3a are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkoxy, halo, CN, substituted or unsubstituted C 1 to C 4 alkyl, perfluoroalkyl, substituted or unsubstituted C 3 to C 7 cycloalkyl, and cycloalkoxy, or R 3 or R 3a and D may optionally be taken together with the atoms to which they are attached to form a 5- to 7-membered ring; R 5 and R 5a are independently selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl, hydroxyalkyl, hydroxyalkylcycloalkyl, substituted or unsubstituted heterocycloalkyl, acyl, alkoxycarbonyl, carboxyalkyl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted cycloalkylalkyl, or R 5 and R 5a and the nitrogen atom to which they are attached may form a ring; R 21 and R 31 are each H or C 1 to C 4 alkyl; R 34 is alkyl; R 35 is H or alkyl; and R 6 is selected from the group consisting of H, C 1 to C 4 alkyl and C 3 to C 7 cycloalkyl.