Patent ID: 8378103

Claim:
A process for preparing tiotropium bromide comprising: a. preparing N-demethyl-tiotropium of formula III, comprising reacting methyl-di-(2-thienyl)-glycolate of formula I, with a scopine salt of formula II-s having an inorganic salt content of about 0.5% to about 40% (w/w) of the total weight, wherein X is selected from the group consisting of Br, Cl, SO 4 , MeCOO, PO 4 , MeSO 3 , tartrate, fumarate, citrate, maleate, succinate, p-toluene suiphonate and amidosulphonate; and b. reacting said N-demethyl-tiotropium with methylbromide in an organic solvent to form tiotropium bromide.