Patent ID: 8084455

Claim:
A method for inhibiting BCR-ABL inhibitor-resistant tyrosine kinase activity comprising contacting a BCR-ABL inhibitor-resistant leukemia with an effective amount of a compound selected from the group consisting of N-{5-[(2R)-2-methoxy-2-phenylethanoyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methylpiperazin-1-yl)benzamide, N-[5-((R)-2-Methoxy-2-phenyl-acetyl)-1,4,5,6-tetrahydro-pyrrolo[3,4-c]pyrazol-3-yl]-4-piperidin-1-yl-benzamide, 4-(4-Ethyl-piperazin-1-yl)-N-[5-((R)-2-methoxy-2-phenyl-acetyl)-1,4,5,6-tetrahydro-pyrrolo[3,4-c]pyrazol-3-yl]-benzamide, 4-(4-Cyclopropyl-piperazin-1-yl)-N-[5-((R)-2-methoxy-2-phenyl-acetyl)-1,4,5,6-tetrahydro-pyrrolo[3,4-c]pyrazol-3-yl]-benzamide, 4-(4-Isopropyl-piperazin-1-yl)-N-[5-((R)-2-methoxy-2-phenyl-acetyl)-1,4,5,6-tetrahydro-pyrrolo[3,4-c]pyrazol-3-yl]-benzamide, or pharmaceutically acceptable salts thereof, and combinations thereof.