Patent ID: 7314882

Claim:
A compound or a pharmaceutically acceptable salt or a stereoisomer according to Formula I: wherein, R 1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, halo, CF 3 , CN, OR 5 NR 6 R 6a ; R 2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, COOR 7 and CONR 7 R 7a ; R 3 and R 3a are hydrogen or R 3 and R 3a taken together form a double bond with oxygen; R 4 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl; R 5 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, CHF 2 and CF 3 ; R 6 and R 6a are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 6 and R 6a taken together can form cycloalkyl or heterocyclyl; R 7 and R 7a are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; or R 7 and R 7a taken together can form cycloalkyl or heterocyclyl; Y is selected from the group consisting of CO and S(O) 2 ; Z is selected from the group consisting of a direct bond, oxygen, NR 8 and alkyl; R 8 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, beteroaryl, arylalkyl and heteroarylalkyl; or R 4 and R 8 taken together can form cycloalkyl or heterocyclyl; n is an integer of 0 or 1.