Patent ID: 7241754

Claim:
A compound having a structure according to formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is H, optionally substituted C 1 -C 5 alkyl, optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, optionally substituted C 3 -C 6 cycloalkyl, (CH 2 ) 2 C(═O)R 7 , CH 2 C(═O)R 7 , or C(═O)R 8 ; R 2 and R 3 are independently H, halogen, optionally substituted C 1 -C 5 alkyl, optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, optionally substituted C 3 -C 6 cycloalkyl, NO, NO 2 , or N(R 8 R 9 ); R 4 is O or a bond; R 5 is H, OR 8 , halogen, OC(═O)R 8 , O(C═O)N(R 8 R 9 ), OSO2R 10 , or O(C═O)NHSO 2 N(R 8 R 9 ); R 6 is H or halogen; or R 5 and R 6 combine to form ═O or ═NOR 8 ; R 7 is H, OH, optionally substituted C 1 -C 5 alkyl, optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, optionally substituted C 3 -C 6 cycloalkyl, OR 8 , or N(R 8 R 9 ); each R 8 is independently H, optionally substituted C 1 -C 5 alkyl, optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, or optionally substituted C 3 -C 6 cycloalkyl; each R 9 is independently H, optionally substituted C 1 -C 5 alkyl, optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, or optionally substituted C 3 -C 6 cycloalkyl; or R 8 and R 9 form, in combination with the nitrogen atom to which they are commonly attached, a 3, 4, 5, or 6 membered heterocyclic ring containing 1, 2, or 3 heteroatoms selected from N, O, and S; and R 10 is optionally substituted C 1 -C 5 alkyl, optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, or optionally substituted C 3 -C 6 cycloalkyl; wherein an optionally substituted C 1 -C 5 alkyl. optionally substituted C 2 -C 5 alkenyl, optionally substituted C 2 -C 5 alkynyl, or optionally substituted C 3 -C 6 cycloalkyl that is substituted contains a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, halo, trifluoromethoxy, trifluoromethyl, hydroxy, alkoxy, cycloalkyloxy, heterocyclooxy, alkanoyl, alkanoyloxy, amino, alkylamino ciuartemary ammonium, aralkylamino, cycloalkylamino, heterocycloamino, dialkylamino, alkanoylamino, thio, alkylthio, cycloalkylthio, heterocyclothio, ureido, nitro, cyano, carboxy, carboxylalkyl, carbamyl, alkoxycarbonyl, alkylthiono, arylthiono, alkylsulfonyl, sulfonamido, and aryloxy.