Patent ID: 7332614

Claim:
A process for making a compound of formula I: said process comprising reacting a substituted indole compound I′: with a heteroaryl or aryl zinc halide of the following formula: or a di heteroaryl or di aryl zinc compound of the following formula: wherein: L is Br or Cl R is H or C 1-8 alkyl X is C 3- C 8 cycloalkyl, aryl, C 1- C 8 alkyl; Y is heteroaryl or aryl; Z is H, HO 2 C—, C 1-8 alkyl O 2 C—, C 1-6 alkyl HNC(O)—, wherein Q is selected from: in the presence of: a Pd- or Ni-containing catalyst, a ligand selected from Ph 3 P, p-Tol 3 P, tri(2-furyl)phosphine. Cy 3 P, tBu 3 P, Cy 2 P(Ph-Ph), dppf and dppb, and a solvent selected from THF, DMF, NMP or a combination thereof, at a temperature of between ambient and 100° C., to provide the compound of formula I.