Patent ID: 7998974

Claim:
A compound represented by Structural Formula (Ia): wherein: R 10 is selected from —CH 2 -piperazinyl, —CH 2 -methylpiperazinyl, —CH 2 -pyrrolidyl, —CH 2 -piperidyl, —CH 2 -morpholino, —CH 2 —N(CH 3 ) 2 , —C(O)—NH—(CH 2 ) n -piperazinyl, —C(O)—NH—(CH 2 ) n -methylpiperazinyl, —C(O)—NH—(CH 2 ) n -pyrrolidyl —C(O)—NH—(CH 2 ) n -morpholino, —C(O)—NH—(CH 2 ) n -piperidyl, or —C(O)—NH—(CH 2 ) n —N(CH 3 ) 2 , wherein n is 1 or 2; R 11 is selected from —C 1 -C 3 straight or branched alkylene or —C(O)—; and each of ring K and ring E is independently substituted with up to three substituents independently selected from halo, —CF 3 , —O—(C 1 -C 3 straight or branched alkyl), —S—(C 1 -C 3 straight or branched alkyl), —N(R 40 )(R 50 ), —S(O) 2 —N(R 40 )(R 50 ), heterocyclyl, —(C 1 -C 3 straight or branched alkyl)-heterocyclyl, —O—(C 1 -C 3 straight or branched alkyl) -heterocyclyl, and —S—(C 1 -C 3 straight or branched alkyl)-heterocyclyl, or is optionally fused to a 5-6 membered heterocyclyl or heteroaryl, wherein any heterocyclyl or heteroaryl is optionally substituted with —C 1 -C 3 straight or branched alkyl.