Patent ID: 8895551

Claim:
A compound having Formula I: a pharmaceutically acceptable salt or a solvate thereof, wherein: R 1 and R 2 are each independently hydrogen, cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkoxycarbonyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted cycloalkyloxy, optionally substituted cycloalkenyloxy, optionally substituted aryloxy, or optionally substituted heterocyclyloxy, or R 1 and R 2 together with the adjacent nitrogen atom form an optionally substituted ring; R 3 and R 4 are each independently hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxy; W is —C(R 5 )(R 6 )— or —O—; R 5 and R 6 are each independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, alkoxycarbonyl, carbamoyl or alkylcarbamoyl; Y is —S(O) 2 —; Z is optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R is alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, alkoxycarbonyl, carbamoyl or alkylcarbamoyl; m is 0 or 1; n is 1 or 2; and p is 0, 1, or 2, excluding compounds wherein Q is (B) and R 2 is N-containing heterocyclyl substituted by fluoronaphtylmethyl.