Patent ID: 8778303

Claim:
A radiopharmaceutical compound comprising: (a) a polypeptide sequence set forth in SEQ ID NO:1 or a sequence having at least 70% sequence similarity to SEQ ID NO:1, wherein the polypeptide comprises a covalent bond between amino acids located at positions 1 and 18, 4 and 14, and 5 and 11 and further comprises a covalent bond between amino acids located at positions 6 and 19; (b) a radioisotope consisting of (i) a technetium core selected from the group consisting of 99m Tc x , 99m Tc 3+ , 99m Tc 4+ , ( 99m Tc═O) 3+ , ( 99m Tc≡N) 2+ , (O═ 99m Tc═O) + , ( 99m Tc(CO) 3 ) + , or [ 99m Tc]HYNIC, wherein x is a redox or oxidation state selected from the group consisting of +7, +6, +5, +4, +3, +2, +1, 0 and −1, or (ii) an isotope selected from the group consisting of 111 In 3+ , 111 In 0 , 111 In 5− , 125 I − , 125 I 0 , 125 I 7+ , 131 I − , 131 I 0 , 131 I 7+ , 18 F − , 18 F 0 , 64 Cu 0 , 64 Cu + , 64 Cu 2+ , 64 Cu 3+ , 11 C, 13 N, 15 O, 67 Ga, 68 Ga, 201 Tl, 177 Lu, 186 Re, and 188 Re; (c) a chelation moiety wherein the chelation moiety is covalently or non-covalently bonded to the polypeptide and is chelated with the radioisotope, or a chemical intermediate wherein the radioisotope is part of the chemical intermediate, and wherein the chemical intermediate is covalently or non-covalently bonded to the polypeptide; or, a salt or hydrate thereof.