Patent ID: 7902257

Claim:
A method of ameliorating or treating a disease or condition associated with inflammation, autoimmune disease, or rheumatoid arthritis, the method comprising administering to a subject an effective amount of a compound having a structure of general formula 46: wherein: A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino, or —OM, where M is a cation selected from ammonium, tetra-alkyl ammonium, Na, K, Mg, and Zn; R a and R b are independently selected from hydrogen, alkyl, aryl, heteroaryl, acyl, silyl, alkoxyacyl and aminoacyl; R 2 is hydrogen, alkyl, perfluoroalkyl, aryl or heteroaryl; R 5 is selected from i)-iv) as follows: i) CH 2 CH(R 6 )CH 2 , where R 6 is hydrogen, alkyl, perfluoroalkyl, aryl, heteroaryl, fluoro, hydroxy or alkoxy; ii) CH 2 C(R 6 R 7 )CH 2 , where R 6 and R 7 are each independently alkyl, perfluoroalkyl, aryl, or fluoro, or R 6 and R 7 are connected together to form a carbocyclic or heterocyclic ring; iii) CH 2 OCH 2 , CH 2 C(O)CH 2 , or CH 2 CH 2 ; and iv) a carbocyclic, heterocyclic, aryl or heteroaryl ring; and R 8 and R 9 are independently selected from hydrogen, alkyl, perfluoroalkyl, alkoxy, aryl and heteroaryl, or R 8 and R 9 are connected together to form a carbocyclic or heterocyclic ring.