Patent ID: 7153847

Claim:
A compound of Formula I: wherein: R 1 is C 1 –C 6 alkyl; C 2 –C 10 alkenyl; C 3 –C 12 cycloalkyl; C 4 –C 8 ; cycloalkenyl; C 1 –C 6 alkyl substitated with 1 to 3 substituents selected from the group consisting of C 1 –C 6 alkoxy, C 3 –C 6 cycloalkyl, (C 1 –C 6 alkyl)-C(C))—, benzoyl optionally substituted in the phenyl ring with 1 to 3 substituents selected from halo, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, trihaloalkyl, and phenyl, acylamino selected from —C(O)NH 2 , —C(O)NH-(phenyl optionally subtituted with halo or C 1 –C 6 alkyl), —C(O)NH—(C 1 –C 6 alkyl), —C(O)NH-(diphenylmethyl), and —C(O)N(C 1 –C 6 alkyl) 2 , carboxymethyl, aminoacyl selected from (C 1 –C 6 alkyl)-C(O)NH— and (phenyl)-C(O)NH—, halo, C 1 –C 6 thioalkoxy, benzylthioalk-oxy, phenyl optionally substituted with 1 to 3 substituents selected from hydroxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, halo, and nitro, thienyl, 3,4-methylenedioxyphenyl, phenoxy optionally substituted with 1 to 3 halo substituents, oximino, and —SO 2 -phenyl; C 2 –C 10 alkenyl substituted with 1 to 3 substituents selected from phenyl; aryl selected from phenyl, naphthyl, and phenyl substituted with 1 to 3 substituents selected from the group consisting of C 1 –C 6 alkyl, C 1 –C 6 alkoxy, halo, nitro, trihalomethyl, hydroxy, and phenoxy; heteroaryl selected from thienyl, 3,4-methylenedioxyphenyl, benzothienyl, and benzofuryl optionally substituted with C 1 –C 6 alkyl; or indanyl; R 2 is C 1 –C 6 alkyl; C 1 –C 6 alkyl substituted with 1 to 3 substituents selected from the group consisting of C 3 –C 6 cycloalkyl, halo, hydroxy, and C 1 –C 6 thioalkoxy; C 3 –C 6 cycloalkyl; phenyl; phenyl substituied with 1–3 sobstituents selected from the group consisting of C 1 –C 6 alkyl, C 1 –C 6 alkoxy, halo, cyano, nitro, trihalomethyl, and C 1 –C 6 thioalkoxy; or thienyl; T is O, S, or a bond covalently connecting R 1 to —CX′X″, provided that when T is O or S then both X′ and X″ are hydrogen; X′ is hydrogen, hydroxy, or fluoro; X″ is hydrogen, hydroxy, or fluoro; The cyclic group defined by W together with —C(H) p C(═X)— forms a caprolactam fused to form a bi- or multi-fused ring system with one or more ring systems selected from the group consisting of cyclohexyl and phenyl which, in turn, each of such bi- or multi-fused ring systems are optionally substituted with 1 to 4 substituents selected from the group consisting of C 1 –C 6 alkyl; C 1 –C 6 alkyl substituted with 1 to 3 substituents selected from the group consisting of C 1 –C 6 alkoxy, C 3 –C 6 cycloalkyl, carboxyl, —C(O)—O—(C 1 –C 6 alkyl), halo, and phenyl; and halo.