Patent ID: 7526387

Claim:
A method for determining the likelihood of breast cancer recurrence or response to hormonal therapy in a mammalian subject comprising: (a) measuring the expression levels of the RNA transcripts of GRB7, HER2, EstR1, PR, Bcl2, CEGP1, SURV, Ki.67, MYBL2, CCNB1, STK15, CTSL2, and STMY3, or their expression products in a biological sample containing tumor cells obtained from said subject; (b) creating the following gene subsets comprising: (i) growth factor subset: GRB7 and HER2; (ii) estrogen receptor subset: EstR1, PR, Bcl2, and CEGP1; (iii) proliferation subset: SURV, Ki.67, MYBL2, CCNB1, and STK15; and (iv) invasion subset: CTSL2, and STMY3; (c) calculating a recurrence score (RS) for said subject by weighting the measured expression levels of each of the gene subsets by contribution to breast cancer recurrence; (d) using said RS to determine the likelihood of breast cancer recurrence or response to therapy; and (e) creating a report summarizing the result of said determination.