Patent ID: 7524846

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: W is OR 9 ; R 1 and R 2 are, independently, H, OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, or methylenedioxy; R 5 is H, (C 1 -C 6 )alkyl, or trifluoromethyl; R 6 and R 7 are, independently, (C 1 -C 6 )alkyl; or R 6 and R 7 together with the carbon to which they are attached form a ring of 4 to 8 carbon atoms; R 8 is benzyl (optionally substituted with benzyloxy or phenyloxy), naphthylmethyl (optionally substituted with one or more R 1 ), phenyl(C 2 -C 6 )alkyl (optionally substituted with one or more R 1 ), heteroarylmethyl (optionally substituted with R 1 ), cycloalkyl, cycloalkenyl, cycloalkylmethyl (where any carbon atom can be optionally replaced with N, S, or O and where said cycloalkylmethyl can be optionally substituted with OH, CF 3 , halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy), or cycloalkenylmethyl (where any carbon atom can be optionally replaced with N, S, or O and where said cycloalkylmethyl can be optionally substituted with OH, CF 3 , halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy); or R 5 and R 8 , together with the nitrogen atom to which R 8 is attached, form a ring optionally substituted with R 5 ; R 9 is H, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkyl-C(═O); t is 1, 2, or 3; and x is 1; except if one of R 1 or R 2 is H or halo and the other is methoxy, fluoro, or trifluoromethyl, then R 8 is not benzyl.