Patent ID: 7863420

Claim:
A process for the production of a composition containing at least one coagulation factor, said process consisting of the following steps: i. adjusting the pH of a plasma fraction, wherein said plasma fraction contains an initial amount of fibronectin and at least one coagulation factor, contains NaCl or KCl at a concentration of 100-200 mM and is characterized by an ionic strength below 500 mM, to a value between pH 4.7 and pH 5.3 so as to form a precipitate comprising 70% to 99% of the initial amount of fibronectin and a supernatant containing said at least one coagulation factor, ii. removing the fibronectin precipitate formed in step (i) to thereby yield a composition containing at least one coagulation factor; and iii. purifying the at least one coagulation factor from the composition obtained in step (ii), wherein steps (i) and (ii) are performed at a temperature that ranges from 20Â° C. to 25Â° C.