Patent ID: 7262202

Claim:
A compound of general formula I: wherein: X 1 is CR 9 ; X 2 is NR 10 ; Z is NH; R 1 , R 2 , R 3 , R 9 and R 10 are independently H, alkyl, aryl, aralkyl, heterocycle, halogeno, NO 2 , CN, OH, alkoxy, aryloxy, (R′″)nNH 2 , (R′″)nNH—R′, (R′″)nN—(R′)(R″), NH-aryl, N-(aryl) 2 , COOH, COO—R′, COO-aryl, CONH 2 , CONH—R′, CON—(R′)(R″), CONH-aryl, CON-(aryl) 2 , SO 3 H, SO 2 NH 2 , CF 3 , CO—R′, or CO-aryl, wherein alkyl, aryl, aralkyl and heterocycle groups may be further substituted with one or more groups selected from halogeno, NO 2 , CN, OH, O-methyl, NH 2 , COOH, CONH 2 and CF 3 ; R 4 , R 5 , R 7 , and R 8 are independently from each other H, substituted or unsubstituted lower alkyl, halogeno, NO 2 , CN, OH, substituted or unsubstituted alkoxy, NH 2 , NH—R′, N—(R′)(R″), COOH, COO—R′, CONH 2 , CONH—R′, CON—(R′)(R″), SO 3 H, SO 2 NH 2 , or CF 3 ; R 6 is H, substituted or unsubstituted lower alkyl, halogeno, NO 2 , CN, OH, substituted or unsubstituted alkoxy, NH 2 , NH—R′, N—(R′)(R″), COOH, COO—R′, SO 3 H, SO 2 NH 2 , or CF 3 ; wherein R′R″ and R′″ are each independently alkyl groups that may be the same or different and n is 0 or 1; and wherein at least two or three of R 1 , R 2 and R 9 are not hydrogen; or a pharmaceutically acceptable salts thereof.