Patent ID: 7109233

Claim:
A compound according to Formula I, wherein: x is 0, 1 or 2; R 1 is either formula A or B wherein, in formula (B), n is an integer from 1 to 5; R 2 is H, C 1-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, Ar—C 0-6 alkyl, Het-C 0-6 alkyl R 9 C(O)—, R 9 C(S)—, R 9 SO 2 —, R 9 OC(O)—, R 3 is H, C 1-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, HetC 0-6 alkyl, ArC 0-6 alkyl, Ar—ArC 0-6 alkyl, Ar-HetC 0-6 alkyl, Het-ArC 0-6 alkyl, or Het-HetC 0-6 alkyl; R 4 is H, C 1-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, Ar—C 0-6 alkyl, Het-C 0-6 alkyl, R 14 C(O)—, R 14 —C(S)—, R 14 SO 2 —, R 14 OC(O)—, R 14 R 13 NC(O)—, R 14 R 13 NC(S)—, or R 14 R 13 NSO 2 ; R 5 is H, C 1-6 alkyl, OC 1-4 alkyl, SC 1-4 alkyl, N(R 9 ) 2 , CH 2 OC 1-4 , CH 2 SC 1-4 , or CH 2 N(R 9 ) 2 ; R 6 is H, C 1-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, Ar—C 0-6 alkyl, or Het-C 0-6 alkyl; R 7 is H, C 1-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, Ar—C 0-6 alkyl, Het-C 0-6 alkyl, R 10 C(O)—, R 10 C(S)—, R 10 SO 2 —, R 9 OC(O)—, R 10 R 13 NC(O)—, or R 10 R 13 NC(S)—; R 8 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, Ar—C 0-6 alkyl or Het-C 0-6 alkyl; R 9 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, Ar—C 0-6 alkyl or Het-C 0-6 alkyl; R 10 is C 1-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, Ar—C 0-6 alkyl or Het-C 0-6 alkyl; R 11 is H, C 1-6 alkyl, Ar—C 0-6 alkyl, C 3-6 cycloalkyl-C 0-6 alkyl, or Het-C 0-6 alkyl; R 12 is H, C 1-6 alkyl, Ar—C 0-6 alkyl, or Het-C 0-6 alkyl; R 13 is H, C 1-6 alkyl, Ar—C 0-6 alkyl, or Het-C 0-6 alkyl; R 14 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-C 0-6 alkyl, C 1-6 alkanoyl, Ar—C 0-6 alkyl or Het-C 0-6 alkyl; R′ is H, C 1-6 alkyl, Ar—C 0-6 alkyl, or Het-C 0-6 alkyl; R″ is H, C 1-6 alkyl, Ar—C 0-6 alkyl, or Het-C 0-6 alkyl; or Z is C(O) or CH 2 ; or a pharmaceutically acceptable salt, hydrate or solvate thereof.