Patent ID: 7875600

Claim:
A compound of formula (I) R 1 is H or NH 2 ; R 2 is optionally substituted aryl or heteroaryl attached via a carbon atom; R 3 is H; optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 3 -C 7 cycloalkyl, halogen; OH or OR 10 ; R 4 is H, optionally substituted C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, aryl or heteroaryl, R 5 is H or optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 6 alkynyl, or C 3 -C 7 cycloalkyl; or R 4 and R 5 together form a 5 or 6-membered heterocyclic ring; R 10 is optionally substituted C 1 -C 6 alkyl; wherein the term “substituted” means substituted with at least one substituent selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, hydroxy(C 1 -C 6 )alkyl, mercapto, mercapto(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile (—CN), oxo, phenyl, monocyclic heterocyclic having 5- or 6 ring members, —COOH, —COOR A , —COR A , —SO 2 R A , —CONH 2 , —SO 2 NH 2 , —CONHR A , —SO 2 NHR A , —CONR A R B , —SO 2 NR A R B , —NH 2 , —NHR A , —NR A R B , —OCONH 2 , —OCONHR A , —OCONR A R B , —NHCOR A , —NR B COR A , —NHCOOR A , —NR B COOR A , —NHSO 2 R A , —NR B SO 2 R A , —NHCONH 2 , —NR A CON H 2 , —NHCONHR B , —NR A CONHR B , —NHCONR A R B or —NR A CONR A R B wherein R A and R B are independently a (C 1 -C 6 )alkyl group wherein phenyl or monocyclic heterocyclic having 5- or 6 ring members may be substituted by any of the foregoing except phenyl and monocyclic heterocyclic having 5- or 6 ring members; or a pharmaceutically acceptable salt thereof PROVIDED THAT: (a) R 2 is not an optionally substituted pyrazolopyridine ring system; and (b) when R 1 and R 3 are hydrogen and R 2 is unsubstituted phenyl then —NR 4 R 5 is not —NH 2 , NHCH 3 or N(CH 3 ) 2 ; and (c) when R 1 is —NH 2 and R 3 is hydrogen, then R 2 is not phenyl or phenyl substituted by any substituent selected from halogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, nitro, —NH 2 , or —NHCOCH 3 .