Patent ID: 8173619

Claim:
A compound of formula I: wherein: each of X and Z is independently selected from H, OH, F, Cl, Br, I, C 1-6 alkyl and NR 5 R 6 , where each of R 5 and R 6 is independently selected from H and C 1-6 alkyl; Y is selected from OH, F, Cl, Br, I, C 1-6 alkyl, C 2-8 alkynyl, and NR 5 R 6 , where each of R 5 and R 6 is independently selected from H and C 1-6 alkyl; each of T and T′ is independently selected from H, F and OH, with the proviso that only one of T and T′ can be OH; Q is selected from O, S and CR 7 R 8 , where R 7 and R 8 are independently selected from H and C 1-6 alkyl, Ar is selected from C 6-30 aryl and C 6-30 heteroaryl, each of which is optionally substituted with one or more substituents independently selected from the group consisting of hydroxy, acyl, acyloxy, nitro, amino, SO 3 H, SH, SR′, wherein R′ is independently selected from the same group as R 1 ; carboxyl, C 1-6 esters, C 1-6 aldehyde, cyano, C 1-6 alkylamino, C 1-6 dialkylamino, thiol, chloro, bromo, fluoro, iodo, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkoxy-C 5-10 aryl, C 5-7 cycloalkyl, C 5-11 cycloalkyl-C 1-6 alkyl, C 5-7 cycloalkenyl, C 5-7 cycloalkynyl, C 5-11 arylC 1-6 alkyl, C 1-6 alkylC 5-11 aryl, C 5-11 aryl, C 1-6 fluoroalkyl and C 2-6 fluoroalkenyl; each of R 1 and R 2 is independently selected from H, and the group consisting of C 1-20 alkyl, C 2-20 alkenyl, C 1-20 alkoxy, C 1-20 alkoxyC 1-20 alkyl, C 1-20 alkoxyC 6-30 aryl, C 2-20 alkynyl, C 3-20 cycloalkylC 6-30 aryl, C 6-30 aryloxy and C 5-20 heterocyclyl, any of which is optionally substituted with optional substituents; each of R 3 and R 4 is independently selected from H, and the group consisting of C 1-20 alkyl, C 2-20 alkenyl, C 1-20 alkoxy, C 1-20 alkoxyC 1-20 alkyl, C 1-20 alkoxyC 6-30 aryl, C 2-20 alkynyl, C 3-20 cycloalkylC 6-30 aryl, C 6-30 aryloxy and C 5-20 heterocyclyl, any of which is optionally substituted with optional substituents; the optional substituents on R 1 , R 2 , R 3 , and R 4 being one or more substituents independently selected from the group consisting of hydroxy, acyl, acyloxy, nitro, amino, amido, SO 3 , H, SH, SR′, wherein R′ is independently selected from the same group as R 1 ; carboxy, C 1-6 esters, C 1-6 aldehyde, cyano, C 1-6 alkylamino, C 1-6 dialkylamino, thiol, chloro, bromo, fluoro, iodo, C 5-7 cycloalkyl, C 5-7 cycloalkenyl, C 5-7 cycloalkynyl, C 5-11 aryl, C 5-11 arylC 1-6 alkyl, and C 5-20 heterocyclyl; and pharmaceutically acceptable salts thereof.