Patent ID: 8216548

Claim:
A method for radiofluorination comprising reaction of a compound of formula (I) with a compound of formula (II): or, a compound of formula (III) with a compound of formula (IV) wherein R1 is a halogen-containing moiety; R2 is an N-alkyl aminooxy group; R3 is an N-alkyl aminoxy group; and R4 is a is a halogen-containing moiety; to give a conjugate of formula (V) or (VI) respectively: wherein Y is alkyl or aryl and the 18 F-Linker group in the compounds of formulae (II) and (V) is selected from a group of synthons comprising an N-alkyl aminoxy moiety linked to the 18 F atom via stable bonds and the 18 F-Linker group in the compounds of formula (IV) and (VI) is selected from the halogen-containing synthons.