Patent ID: 7316917

Claim:
A process for the preparation of a bicyclic-heteroaryl-2-carboxylic acid 7 of the formula wherein Y is (CH 2 ) n ; n is 1; X is —CH 2 —; which comprises enzymatic hydrolysis with an effective hydrolyzing enzyme selected from C. antarctica lipase B, Aspergillus sp. acylase, Aspergillus oryzae protease M, C. rugosa lipase, and lipase from Pseudomonas sp. of bicyclic-heteroaryl-2-carboxylic acid ester 6 wherein X and Y are defined as above and R 1 is alkyl of 1 to 6 carbon atoms to produce the bicyclic-heteroaryl-2-carboxylic acid 7 of the formula wherein X and Y are as defined as above and isolating the bicyclic-heteroaryl-2-carboxylic acid 7.