Patent ID: 8283145

Claim:
An isolated UDP-glucuronic acid-producing bacterium, which is introduced with a kfoA gene derived from the Escherichia coli K4 strain and a kfoC gene derived from Escherichia coli K4 strain, wherein said bacterium has chondroitin-producing ability, and wherein the kfoA gene encodes a protein selected from the group consisting of (A) and (B), and wherein the kfoC gene encodes a protein selected from the group consisting of (C), (D), (E) and (F): (A) a protein comprising the amino acid sequence of SEQ ID NO: 2; (B) a protein comprising the amino acid sequence of SEQ ID NO: 2 comprising substitution, deletion, insertion, or addition of 1-20 amino acids and having UDP-glucose-4-epimerase activity; (C) a protein comprising the amino acid sequence of SEQ ID NO: 4; (D) a protein comprising the amino acid sequence of SEQ ID NO: 4 comprising substitution, deletion, insertion, or addition of 1-20 amino acids and having chondroitin synthase activity; (E) a protein comprising the amino acid sequence of SEQ ID NO: 6; and (F) a protein comprising the amino acid sequence of SEQ ID NO: 6 comprising substitution, deletion, insertion, or addition of 1-20 amino acids and having chondroitin synthase activity.