Patent ID: 7196094

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or N-oxide or stereochemically isomeric form thereof, wherein r is 0 or 1; >Y 1 —Y 2 — is a trivalent radical of formula >C═N-(y-1); R 1 is halo; R 2 is a thiophene, furyl, pyridyl, diazolyl, oxazolyl, benzodiazolyl, benzotriazolyl, or quinolinyl group, optionally substituted by halo, cyano, C 1-6 alkyl, or aryl; R 3 is hydrogen, or a radical of formula —O—R 10 (b-1) or —NR 11 R 12 (b-3); wherein R 10 R 11 and R 12 are hydrogen; and R 12 is hydrogen or hydroxyl; R 4 is a radical of formula wherein R 16 is hydrogen; R 17 is C 1-6 alkyl; R 18 is C 1-6 alkyl; R 18a is hydrogen; R 5 is C 1-6 alkyl, —CH 2 —C 3-10 cycloalkyl-, —C 1-6 alkyl-Ar 2 ; R 7 is oxygen; or R 6 and R 7 together form a trivalent radical of formula: —CR 30 ═N—N═ (x-2)or —N═N—N═ (x-4) wherein R 30 is hydrogen; Ar is phenyl, or phenyl substituted by one to five substituents each independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, haloC 1-6 alkyl, -alkylNH 2 , C 1-6 alkyloxy, OCF 3 , hydroxycarbonyl, C 1-6 alkyloxycarbonyl, or a bivalent substituent of formula —O—CH 2 —O— or —O—CH 2 —CH 2 —O—.