Patent ID: 8481030

Claim:
An isolated human monoclonal IgG antibody that binds specifically to human tissue factor pathway inhibitor, wherein the antibody comprises: (a) a human heavy chain comprising: a CDR 1 region with the amino acid sequence shown in SEQ ID NO: 35, optionally comprising a substitution relative to SEQ ID NO: 1 of S35D; a CDR2 region with the amino acid sequence of shown in SEQ ID NO: 36, optionally comprising a substitution relative to SEQ ID NO: 1 of S55R; a CDR3 region with the amino acid sequence shown in SEQ ID NO: 37, optionally comprising a substitution relative to SEQ ID NO: 1 of K99L. (b) a human light chain comprising: a CDR1 region with the amino acid sequence shown in SEQ ID NO: 38; a CDR2 region with the amino acid sequence shown in SEQ ID NO: 39, comprising at least one substitution relative to SEQ ID NO: 2 selected from the group consisting of Y48F and N51V and combinations thereof; a CDR3 region with the amino acid sequence shown in SEQ ID NO: 40, comprising a substitution relative to SEQ ID NO: 2 of D91W.