Patent ID: 8247408

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt, wherein R 1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl; X is —NR 3 —; R 3 is hydrogen; R 4 is optionally substituted alkyl; R 5 is hydrogen; R 6 is phenyl or heteroaryl where the phenyl and heteroaryl are optionally substituted with 1, 2, 3, 4, or 5 R 9 groups; and R 2 is R 2b where R 2b is aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, or heterocycloalkylalkyl, and where the aryl, cycloalkyl, and heterocycloalkyl, either alone or as part of another group within R 2b , are optionally substituted with 1, 2, 3, 4, or 5 R 8 groups; each R 8 , when present, is independently hydroxy, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, alkoxycarbonyl, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminoalkyloxy, alkylaminoalkyloxy, dialkylaminoalkyloxy, alkoxyalkylaminoalkyl, heterocycloalkyl, heterocycloalkylalkyl, heterocycloalkylalkyloxy, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl and where the cycloalkyl, aryl, heterocycloalkyl, and heteroaryl, each either alone or as part of another group within R 8 , are independently optionally substituted with 1, 2, 3, or 4 groups selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, alkylcarbonyl, alkoxycarbonyl, and arylalkyl; and each R 9 , when present, is independently halo, alkyl, haloalkyl, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, alkoxyalkyl, carboxyalkyl, cyano, alkoxycarbonyl, aminoalkyl, cycloalkyl, aryl, arylalkyl, aryloxy, heterocycloalkyl, or heteroaryl and where the cycloalkyl, aryl, heterocycloalkyl, and heteroaryl, each either alone or as part of another group within R 9 , are independently optionally substituted with 1, 2, 3, or 4 groups selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, amino, alkylamino, and dialkylamino.