Patent ID: 7060723

Claim:
A method of treating an epileptic condition in a mammal, comprising administering to said mammal an effective amount of a selective persistent sodium channel antagonist, wherein said antagonist has at least 20-fold selectivity for a persistent sodium current relative to a transient sodium current, and wherein said antagonist is a compound included in formula 1, or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof: wherein, Ar 1 is thienyl or a substituted thienyl; Ar 2 is phenyl or a substituted phenyl; Y is absent or R 1 is selected from hydrogen and a C 1 to C 8 alkyl; R 2 and R 3 are independently selected from hydrogen, hydroxy, fluoro, and a C 1 to C 8 alkyl; and n is 1, 2, 3, 4, 5, or 6.