Patent ID: 7897604

Claim:
A method of inhibiting PMPMEase in a patient, comprising administering to the individual an effective amount of an inhibitor of PMPMEase, wherein the inhibitor has the formula: where R 1 is a group selected from substituted or unsubstituted prenyl or polyisoprenyl; X is a linking group; the two atoms between the X and Y groups are the bridge and are two carbon atoms or nitrogen, oxygen, or sulfur may be used in place of one of the carbon atoms; R 2 is a group substituted with an open chain alkyl, alicyclic, aryl, or aryloxy group containing one or more salt-forming basic or acidic groups, either separately or in combination which may be on or be components of heterocycles selected from piperizine, piperidine, and pyrrolidine and R 2 is separated from the bridge by a tether; and Y is selected from where R 3 is alkyl, substituted alkyl, aryl, substituted aryl, SR 5 , OR 5 , NHR 5 , or NR 5 R 6 , R 4 is alkyl, substituted alkyl, aryl or substituted aryl, and R 5 and R 6 are alkyl, substituted alkyl, aryl or substituted aryl; and wherein if Y is and the bridge atoms are both C then R 3 is not OR 5 and wherein if Y has two R groups they may be distinct or combined in a cyclic or heterocyclic structure.