Patent ID: 7294622

Claim:
A compound of formula (I): wherein: X is CH 2 , O, NR 1 , SO 2 or S; Ar 1 is a 5- or 6-membered aromatic or heterocyclic ring optionally substituted with 0, 1, 2, or 3 R e moieties, said ring having 0, 1, 2 or 3 nitrogen, oxygen or sulfur atoms, but no more than 2 oxygen atoms or 2 sulfur atoms or 1 oxygen and 1 sulfur atom; R 1 is H, C 1-3 alkylC 3-6 cycloalkyl, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl C 3-6 cycloalkyl, C 2-4 alkylNR a R b , C 1-4 alkylC(═O)R d ; or C 1-3 alkylphenyl substituted with 0, 1, 2 or 3 R e ; R a and R b are at each occurrence independently selected from H, C 1-4 alkyl or C 3-6 cycloalkyl, or R a and R b and the N to which they are attached in combination form a 5 or 6-membered N-linked heterocycle having 2 nitrogen atoms, wherein the non-linked nitrogen is substituted with R c or 1 nitrogen and 1 oxygen, ring atoms wherein there is no non-linked nitrogen; R c is, at each occurrence independently selected from H, C 1-3 alkyl, or substituted phenyl with 0, 1, 2, or 3 R e ; R d is, at each occurrence independently selected from C 1-3 alkyl, hydroxy, C 1-3 alkoxy, or NR a R b ; R e is, at each occurrence independently selected from H, OH, F, Cl, Br, I, CN, NO 2 , CF 3 , C 1-6 alkyl, or C 1-6 alkoxy; R 2 and R 3 are at each occurrence independently selected from H, C 1-6 alkyl, C 4-6 cycloalkyl, aryl, or heteroaryl, or R 2 and R 3 in combination form a fused phenyl or cyclohexyl moiety that may be substituted with 0, 1 or 2 R f moieties, R f is NO 2 , F, Cl, Br, I, CF 3 , CN, C 1-6 alkyl, or C 1-6 alkoxy; R 4 is H, CHR 7 R 8 , 5- or 6- membered cycloalkyl, 5- or 6-membered heterocyclic, 5 or 6-membered aromatic ring optionally substituted with 0, 1, or 2 R f moities, said heterocycic ring having 0, 1, 2 or 3 nitrogen, oxygen or sulfur atoms, but no more than 2 oxygen atoms or 2 sulfur atoms or 1 oxygen and 1 sulfur atom; R 5 is C 1-3 alkylR 9 or CH(OH)R 10 ; R 7 and R 8 are, at each occurrence are independently selected from H, C 1-4 alkyl, OH, SH, CH 2 SCH 3 , CONH 2 , CH 2 CONH 2 , CO 2 H, CH 2 CO 2 H, (CH 2 ) 3 NHCH(NH 2 ) 2 C 1-4 alkylamino, indolyl, imidazolyl, phenyl or hydroxyphenyl R 7 and R 8 in combination form a 6-membered aromatic or heterocyclic ring optionally substituted with 0, 1 or 2 R f moieties said heterocyclic ring having 0, 1, 2 or 3 nitrogen, oxygen or sulfur atoms, but no more than 2 oxygen atoms or 2 sulfur atoms or 1 oxygen and 1 sulfur atom; R 9 is phenyl substituted with 0, 1, 2 or 3 R e ; R 10 is alkyl or R 9 ; or a pharmaceutically acceptable salt thereof.