Patent ID: 7674460

Claim:
A pharmaceutical composition comprising a pharmaceutically effective amount of an HER2 antagonist or a pharmaceutically acceptable salt thereof, and a pharmaceutically effective amount of PCDGF antagonist or a pharmaceutically acceptable salt thereof, wherein the HER2 antagonist is a HER2 antibody or an antigen-binding fragment thereof and the PCDGF antagonist is an anti-PCDGF antibody produced from a hybridoma cell line selected from the group consisting of 6B3 hybridoma cell line (ATCC Accession Number PTA-5262), 6B2 hybridoma cell line (ATCC Accession Number PTA-5261), 6C12 hybridoma cell line (ATCC Accession Number PTA5597), 5B4 hybridoma cell line (ATCC Accession Number PTA-5260), 5G6 hybridoma cell line (ATCC Accession Number PTA-5595), 4D1 hybridoma cell line (ATCC Accession Number PTA-5593), 3F8 hybridoma cell line (ATCC Accession Number PTA-5591), 3F5 hybridoma cell line (ATCC Accession Number PTA-5259), 3F4 hybridoma cell line (ATCC Accession Number PTA-5590), 3G2 (ATCC Accession Number PTA-5592), 4F10 (ATCC Accession Number PTA8763), and 2A5 hybridoma cell line (ATCC Accession Number PTA-5589) or an antigen-binding fragment thereof.