Patent ID: 8383824

Claim:
A compound according to formula I wherein: R 1 is CH═CHAr, C≡CAr, [C(R 5 ) 2 ] 2 Ar or naphthyl wherein said naphthyl is optionally substituted with [C(R 5 ) 2 ] 0-3 NR a R b ; Ar is phenyl or, pyridinyl or pyridazinyl wherein said phenyl and pyridinyl are Ar is optionally independently substituted with one to three substitutents selected from the group consisting of: (a) [C(R 5 ) 2 ] 0-3 NR a R b , (b) C 1-10 hydroxyalkyl wherein one or two carbon atoms optionally can be replaced by oxygen provided that the replacement does not form a peroxide, (c) C 1-3 alkoxy-C 1-6 alkyl, (d) carboxyl, (e) X 1 [C(R 5 ) 2 ] 1-6 CO 2 R 4 wherein X 1 is O, NR 5 , or a bond and R 4 is hydrogen or C 1-6 alkyl, (f) C 1-6 alkoxycarbonyl, (g) halogen, (h) [C(R 5 ) 2 ] 0-3 CN, (i) C 1-6 alkyl, and (j) C 1-6 haloalkyl; R 2 is hydrogen, C 1-6 alkoxy, halogen or C 1-6 alkyl; R 3 is R 5 is independently in each occurrence hydrogen or C 1-3 alkyl; R 7 is selected from the group consisting of: (a) halogen, (b) C 1-6 alkyl wherein one or two carbon atoms optionally can be replaced by oxygen provided that the replacement does not form a peroxide, (c) C 1-3 haloalkyl, (d) C 1-3 alkoxy, (e) C 2-6 hydroxyalkyl wherein one or two carbon atoms optionally can be replaced by oxygen provided that the replacement does not form a peroxide or a hemiacetal; (f) NR 5 [C(R 5 ) 2 ]—C 2-6 hydroxyalkyl; (g) cyano-C 1-3 alkyl, (h) X 2 [C(R 5 ) 2 ] 1-6 CO 2 H, (i) [C(R 5 ) 2 ] 1-6 NR c R d , and (j) X 2 —[C(R 5 ) 2 ] 2-6 NR c R d wherein X 2 is O or NR 5 ; R 8 is hydrogen or CH 2 OR 9 wherein R 9 is valine, proline or P(═O)(OH) 2 ; R 9 is hydrogen or C 1-6 alkyl; Y is hydrogen or hydroxyl; m is zero or one; R a and R b are (i) independently in each occurrence (a) hydrogen, (b) C 1-6 alkyl, (c) SO 2 R 6 wherein R 6 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-3 alkyl, C 1-6 alkoxy-C 1-6 alkyl or SO 2/Br [C(R 5 ) 2 ] 0-6 NR c R d , or, (d) C 1-3 haloalkyl, (e) C 1-6 acyl, (f) carbamoyl, (g) C 1-3 alkylcarbamoyl, or, (h) C 1-3 dialkylcarbamoyl, (d) C 1-6 acyl, (e) carbamoyl, (f) C 1-3 alkylcarbamoyl, or (g) C 1-3 dialkylcarbamoyl, or (ii) R a and R b taken together with the nitrogen to which they are attached are an optionally substituted cyclic amine; R c and R d are independently hydrogen or C 1-6 alkyl or R c and R d together with the nitrogen to which they are attached are an optionally substituted cyclic amine; or, a pharmaceutically acceptable salt thereof.