Patent ID: 8796439

Claim:
A nucleic acid molecule comprising a nucleotide sequence encoding a Light Chain Variable Region (LCVR) or a fragment thereof of an antibody which is capable of specifically binding to beta-amyloid 1-40 and to monomeric, oligomeric or polymeric forms of beta-amyloid 1-42, wherein said LCVR or fragment thereof comprises: (i) human- or primate-derived framework regions, (ii) an LCVR CDR1 comprising the amino acid sequence of SEQ ID NO: 4, (iii) an LCVR CDR2 comprising the amino acid sequence of SEQ ID NO: 5 or the amino acid sequence of SEQ ID NO: 5 with one amino acid substitution, and (iv) an LCVR CDR3 comprising the amino acid sequence of SEQ ID NO: 6, and wherein said LCVR or fragment thereof comprises an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ ID NO: 12.