Patent ID: 8586552

Claim:
A compound of formula wherein R 2′ is chosen from —OH and —NH 2 ; R 3′ is chosen from H and —OH; R 1 is chosen from H, —C(═NH)NH 2 , and —C(═O)R 10 , wherein R 10 is chosen from —(C 1 -C 20 )alkyl, —(C 3 -C 10 )carbocycle, —(C 3 -C 9 )heterocycle, —(C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle, and —(C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle wherein in said (C 1 -C 20 )alkyl or in the (C 1 -C 8 )alkyl portion of said (C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle or (C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle, one or two —CH— may be replaced with —N—, two —CH— may be replaced by —C═C—, and one or two —CH 2 — may be replaced by —O—, —S—, —SO—, —SO 2 —, —C≡C—, a (C 3 -C 10 )carbocycle or a (C 3 -C 6 )heterocycle and said (C 1 -C 20 )alkyl, (C 3 -C 10 )carbocycle, (C 3 -C 9 )heterocycle, (C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle, (C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle may be additionally substituted with from one to three substituents chosen independently from —CH 3 , —OH, —NH 2 , —COOH, ═O, —NHCONH 2 , —NHC(═NH)NH 2 , —CN or halogen; R 5 is chosen from H, halogen, N 3 , —(C 1 -C 4 )alkynyl and —NHR 50 , wherein R 50 is chosen from H, —(C 3 -C 10 )carbocycle, —(C 3 -C 9 )heterocycle, —(C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle, —(C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle and the deshydroxy residue of an aminoacid; R 7 is chosen from H, —(C 1 -C 6 )alkyl and hydroxy-(C 1 -C 6 )alkyl; R 8 is chosen from —(C 1 -C 20 )alkyl, —(C 3 -C 10 )carbocycle, —(C 3 -C 9 )heterocycle, —(C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle, —(C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle, —NR 80 R 81 , and —C(═NH)NH 2 , wherein R 80 and R 81 are chosen independently from H and —(C 1 -C 6 )alkyl; in said (C 1 -C 20 )alkyl or in the (C 1 -C 8 )alkyl portion of said (C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle or (C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle, one or two —CH— may be replaced with —N—, two —CH— may be replaced by —C═C—, and one or two —CH 2 — may be replaced by —O—, —S—, —SO—, —SO 2 —, —C≡C—, a (C 3 -C 10 )carbocycle or a (C 3 -C 6 )heterocycle; and said (C 1 -C 20 )alkyl, (C 3 -C 10 )carbocycle, (C 3 -C 9 )heterocycle, (C 1 -C 8 )alkyl(C 3 -C 10 )carbocycle, (C 1 -C 8 )alkyl(C 3 -C 9 )heterocycle may be additionally substituted with from one to three substituents chosen independently from —CH 3 , —CH 2 CH 3 , —OH, —CH 2 OH, —NH 2 , —CH 2 NH 2 , —COOH, ═O, —NHCONH 2 , —NHC(═NH)NH 2 , —CN and halogen; or R 7 and R 8 A, taken together with the nitrogen to which they are attached, form a (C 3 -C 9 )heterocycle, said (C 3 -C 9 )heterocycle optionally substituted with from one to three substituents chosen independently from —CH 3 , —CH 2 CH 3 , —OH, —CH 2 OH, —NH 2 , —CH 2 NH 2 , —COOH, ═O, —NHCONH 2 , —NHC(═NH)NH 2 , —CN and halogen; and A is chosen from a direct bond, —(C═O)—, —C(═O)O—, —NH(C═O)—, —(C═O)NH—, —NH(C═O)NH—, —(C═S)NH—, —NH(C═S)—, and —NH(C═S)NH—.