Patent ID: 7915243

Claim:
A medicated composition for topical application, comprising active ingredients consisting of fluocinolone acetonide, hydroquinone, and tretinoin, wherein the composition is a cream made by a process comprising the steps of: (a) mixing water and at least one hydrophilic compound to form an aqueous phase; (b) mixing at least two hydrophobic compounds to form a non-aqueous phase; (c) mixing the aqueous phase and non-aqueous phase to form a biphasic mixture, wherein steps (a) through (c) are conducted in the absence of an emulsifier; (d) mixing fluocinolone acetonide and tretinoin into the biphasic mixture of step (c); (e) adding at least one emulsifier after step (c) into the biphasic mixture of step (c), or during step (d); and (f) homogenizing the mixture to form an emulsion; wherein hydroquinone is added after adding the at least one emulsifier; and wherein the composition has higher viscosity than a composition made by a process differing only by the addition of an emulsifier to an aqueous or non-aqueous phase prior to mixing the phases.