Patent ID: 7115596

Claim:
A compound corresponding to Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from the group consisting of —CH(R 2 )—, —N(R 3 )—, —O—, —S—, —S(O) 2 —, and —C(O)—; Z 1 is selected from the group consisting of hydrogen, heteroaryl, and optionally substituted alkyl or aryl, wherein the substituent is selected from the group consisting of alkyl, halogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, acyl, —S—, —SO—, —SO 2 —, sulfonamido, aryl, and heteroaryl; X 1 is a carbon chain of 1 to 3 carbon atoms with or without a carbon-carbon unsaturated bond; X 1 is selected from the group consisting of —O—, —S—, —SO—, —SO 2 —, —N—, and —CH 2 —; R 2 is H, hydroxy, or alkoxy; R 3 is selected from the group consisting of hydrogen, heteroaryl, optionally substituted alkyl or aryl, wherein the substituent is selected from the group consisting of alkyl, halogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, acyl, —S—, —SO—, —SO 2 , sulfonamido, aryl, and heteroaryl; R 4 is carbon or nitrogen; R 5 is selected from the group consisting of hydrogen, heteroaryl, and optionally substituted alkyl or aryl, wherein the substituent is selected from the group consisting of alkyl, halogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, acyl, —S—, —SO—, —SO 2 , sulfonamido, aryl, and heteroaryl; R 6 is selected from the group consisting of hydrogen, heteroaryl, an electron pair, and optionally substituted alkyl or aryl, wherein the substituent is selected from the group consisting of alkyl, halogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, acyl, —S—, —SO—, —SO 2 , sulfonamido, aryl, and heteroaryl; R 7 is hydroxy or alkoxy; X 3 is selected from the group consisting of: wherein: X 4 is selected from the group consisting of hydrogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyclicamino, heterocyclo, —N—SO 2 R x wherein R x is alkyl or aryl, and optionally substituted hydrocarbyl, wherein the substituent is selected from the group consisting of alkyl, halogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, acyl, —S—, —SO—, —SO 2 —, sulfonamido, aryl, and heteroaryl; X 5 , X 6 , and X 8 are independently selected from the group consisting of hydrogen, heterocyclo, and optionally substituted hydrocarbyl, wherein the substituent is selected from the group consisting of alkyl, halogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, acyl, —S—, —SO—, —SO 2 —, sulfonamido, aryl, and heteroaryl; X 7 is selected from the group consisting of —CH 2 , —CH 2 O—, —OCH 2 — —S—, —SO—, —SO 2 —, —O—, —C(O)—, —CH(OH)—, —NH—, and —NX 8 ; and X 9 is ═O or —OH.