Patent ID: 8211894

Claim:
A method of treating a mammal having a medical condition ameliorated by treatment with a mu opioid receptor antagonist, wherein the medical condition is opioid-induced bowel dysfunction or post-operative ileus, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein: A is a five-membered heteroarylene ring containing one, two, three, or four heteroatoms selected from nitrogen, oxygen and sulfur, wherein not more than one of the heteroatoms is oxygen or sulfur; R 1 is selected from —C(O)OR a , —C(O)NR b R c , C 2-6 alkenyl, C 1-6 alkyl, C 3-12 cycloalkyl, and phenyl, wherein C 1-6 alkyl is optionally substituted with one or two R 3 , C 3-12 cycloalkyl is optionally substituted with one or two halo or with —OR a or —NR b R c , and phenyl is optionally substituted with one or two halo or with —OR a , —NR b R c , or C 1-4 alkyl, wherein C 1-4 alkyl is optionally substituted with —OR a ; R 2 is hydrogen or phenyl; R 3 is selected from —C(O)OR a , —C(O)NR d R e , —OR f , —NR b R g , —CN, C 3-6 cycloalkyl, phenyl, and naphthyl, wherein C 3-6 cycloalkyl is optionally substituted with one or two halo or with —OR a , and phenyl is optionally substituted with one or two halo or with —CN; R a , R b , R c , R d are each independently hydrogen or C 1-3 alkyl; R e is hydrogen or C 1-3 alkyl, optionally substituted with C 3-6 cycloalkyl, —OR a , phenyl, pyridyl, or 4-phenylpiperazinyl; or R d and R e taken together with the nitrogen atom to which they are attached form piperidinyl; R f is hydrogen, C 1-3 alkyl, or phenyl; R g is hydrogen or C 1-3 alkyl, optionally substituted with phenyl; and m is 0, 1, or 2; provided that when m is 0, R 2 is H; or a pharmaceutically-acceptable salt thereof.