Patent ID: 8362233

Claim:
A SIMRA compound having the sequence: (a) 5′-AUGCUGCGCUG-M-GUCGCGUCGUA-5′ (5′-SEQ ID NO: 12-3′-M-3′-SEQ ID NO: 12-5′); (b) 5′-UG 1 CUG 1 CUUUUG 1 -X-G 1 UUUUCG 1 UCG 1 U-5′ (5′-SEQ ID NO: 50-3′-X-3′-SEQ ID NO: 50-5′); or (c) 5′-UG 1 UUG 1 UUUG 1 UG 1 -X-G 1 UG 1 UUUG 1 UUG 1 U-5′ (5′-SEQ ID NO: 51-3′-X-3′-SEQ ID NO: 51-5′); or (d) 5′-UG 1 AUG 1 AAG 1 CUU-X-UUCG 1 AAG 1 UAG 1 U-5′ (5′-SEQ ID NO: 52-3′-X-3′-SEQ ID NO: 52-5′); or wherein G 1 is 7-deaza-rG, M is cis,cis-cyclohexanetriol, and X is a glycerol linker.