Patent ID: 7981908

Claim:
A multiple unit pharmaceutical composition, wherein the active ingredients of said composition consist of a pharmaceutically effective amount of: (i) a parietal cell activator, wherein the parietal cell activator is one or more small carboxylic acid molecules, or any salts thereof, wherein the small carboxylic acid molecules or any salts thereof are saturated or non-saturated monocarboxylic, dicarboxylic, or tricarboxylic acid molecules or any salts thereof having between three to six carbon atoms selected from the group consisting of maleic acid, succinic acid, citric acid, pyruvate, fumarate, alpha ketoglutarate, succinyl-CoA and oxaloacetate; and (ii) an enteric-coated irreversible gastric H + /K + -ATPase proton pump inhibitor (PPI) formulated for absorption in the small intestine, wherein the parietal cell activator is in an amount between 200 to 600 mg and the PPI is omeprazole in an amount of 20 to 80 mg, wherein the composition is suitable for administration to a human patient, wherein the composition disintegrates in the stomach and the release of the active ingredients is controlled such that the activity of the PPI is synchronized with the parietal cell activity, wherein the parietal cell activator is released in the stomach in an amount sufficient to reduce gastric acid secretion in conjunction with the PPI, and wherein the enteric-coated PPI and the parietal cell activator are physically separated within the multiple unit composition.