Patent ID: 7807841

Claim:
A compound having the structure of Formula (1): wherein, (a) A is NR 1 —CR 2 R 3 or N═CR 2 ; X is O; Z is CR 6 ═CR 6 or C(R 6 ) 2 —C(R 6 ) 2 ; (b) R 1 is H, or an optionally substituted moiety selected from -L 1 -alkyl, -L 1 -cycloalkyl, -L 1 -heteroalkyl, -L 1 -haloalkyl, -L 1 -aryl, -L 1 -heterocycloalkyl, and -L 1 -heteroaryl, wherein L 1 is selected from a bond, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 , and —S(O)NH—; wherein said optional substituents of an R 1 moiety are selected from halogen, OH, C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkyl and halo-C 1-6 alkoxy; R 2 and R 3 are independently selected from H, halogen, NH 2 , SH, NO 2 , CN, and an optionally substituted moiety selected from -L 2 -alkyl, -L 2 -cycloalkyl, -L 2 -heteroalkyl, -L 2 -haloalkyl, -L 2 -aryl, -L 2 -heterocycloalkyl, and -L 2 -heteroaryl, wherein L 2 is selected from a bond, O, NH, S, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 —, and —S(O)NH—; wherein said optional substituents of an R 2 or R 3 moiety are selected from halogen, OH, —S(O) 2 -phenyl, C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkyl and halo-C 1-6 alkoxy; or R 1 and R 2 together form an optionally substituted 3 to 8-membered heterocyclic ring; or R 2 and R 3 together form an optionally substituted 3 to 8-membered cycloalkyl, carbocyclic or heterocyclic ring; (c) each R 4 is independently selected from H, halogen, OH, NH 2 , SH, NO 2 , CN, and an optionally substituted moiety selected from -L 2 -alkyl, -L 2 -cycloalkyl, -L 2 -heteroalkyl, -L 2 -haloalkyl, -L 2 -aryl, -L 2 -heterocycloalkyl, and -L 2 -heteroaryl, wherein L 2 is selected from a bond, O, NH, S, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 , and —S(O)NH—; (d) each R 5 is independently selected from halogen, OH, NH 2 , SH, NO 2 , CN, and an optionally substituted moiety selected from -L 2 -alkyl, -L 2 -cycloalkyl, -L 2 -heteroalkyl, -L 2 -haloalkyl, -L 2 -aryl, -L 2 -heterocycloalkyl, and -L 2 -heteroaryl, wherein L 2 is selected from a bond, O, NH, S, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 , and —S(O)NH—, and wherein each m is independently selected from 0, 1, 2, 3, 4, and 5; (e) each R 6 is independently selected from H, halogen, OH, NH 2 , SH, NO 2 , CN, and an optionally substituted moiety selected from -L 2 -alkyl, -L 2 -cycloalkyl, -L 2 -heteroalkyl, -L 2 -haloalkyl, -L 2 -aryl, -L 2 -heterocycloalkyl, and -L 2 -heteroaryl, wherein L 2 is selected from a bond, O, NH, S, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—, —S(O)—, —S(O) 2 , and —S(O)NH—, or any two R 6 groups can together form a 3 to 8-membered carbocyclic or heterocyclic ring; and (f) each R 7 and R 8 is independently selected from H and (C 1 -C 4 )alkyl; and a pharmaceutically acceptable salt, or pharmaceutically acceptable N-oxide thereof.