Patent ID: 8034820

Claim:
An orally administered pharmaceutical composition, comprising: (a) (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione represented by the formula (I): or a pharmaceutically acceptable salt thereof, and (b) a selective serotonin reuptake inhibitor selected from the group consisting of paroxetine or a pharmaceutically acceptable salt and/or hydrate thereof, and fluoxetine or a pharmaceutically acceptable salt and/or hydrate thereof, wherein a dose of said composition provides 0.0001-50 mg/kg of said (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or said pharmaceutically acceptable salt thereof, and 0.001-1000 mg/kg of said serotonin reuptake inhibitor.