Patent ID: 8877170

Claim:
A medical device comprising: a substrate comprising a graft polymer, wherein the main chain of the graft polymer is non-bioabsorbable and is selected from the group consisting of polyethylene terephthalate, polypropylene, polytetrafluoroethylene, a nylon, a polyurethane, a silicone, an ultra-high molecular weight polyethylene, a polybutester, a polyaryletherketone, and copolymers and combinations thereof; and an amphiphilic polymer comprising both: (1) a hydrophilic domain composed of chitosan having a degree of acetylation that is less than or equal to 50%, the hydrophilic domain having an octanol-water partition coefficient (log P OW ) of less than 1.0; and (2) a hydrophobic domain composed of chitosan having a degree of acetylation that is greater than 50%, the hydrophobic domain having an octanol-water partition coefficient (log P OW ) of greater than 5; and wherein the hydrophobic domain is covalently bonded to a side chain of the graft polymer via a triazole linkage.