Patent ID: 8158810

Claim:
A compound of the formula: wherein: R 1 is phenyl optionally substituted with CO 2 CH 2 CH 3 , CN, CONH 2 , CO 2 H, haloalkyl, —O-haloalkyl, CO 2 CH 2 CH 2 -heterocyclyl, where heterocyclyl is morpholinyl, piperazinyl, and CO 2 -alkyl where alkyl is optionally substituted with N(CH3)2 or Si(CH3)3; R 2 is —NHSO 2 —CH 3 , OH, NO 2 , NH 2 , CH 2 OH, NHCONHCH 3 , OCH 2 CONH 2 , OCOCH 3 , B(OH) 2 , CONH 2 , CN, CH 3 , CNHNHOH, SO 2 NH 2 , CNOCH 3 NH 2 , or NHCOCH 3 R 3 is hydrogen; X Y and Z are chosen from —CR 7 —, in which R 7 is hydrogen, lower alkyl, lower alkoxy, or halo; V is oxygen, sulfur, or —NH—; and W is -Q 1 -T-Q 2 -, wherein Q 1 is a covalent bond or C 1-6 linear or branched alkylene optionally substituted with hydroxy, lower alkoxy, amino, cyano, or ═O; Q 2 is C 1-6 linear or branched alkylene optionally substituted with hydroxy, lower alkoxy, amino, cyano, or ═O; and T is a covalent bond, —O—, or —NH—, or T and Q 1 may together form a covalent bond; or a pharmaceutically acceptable salt thereof.