Patent ID: 8399668

Claim:
A process for preparing a 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides of the formula (I) or pharmaceutically acceptable salts thereof: wherein R 1 and R 2 independently represent hydrogen or halogen atom or alkyl, cycloalkyl, aryl, aroyl, carboxyl esters, cyano or nitro group, which process comprises: (a) reacting a pyrrole of the formula (II): wherein R 1 and R 2 are as defined above, with acetyl chloride in the presence of a Lewis acid; (b) reacting the resultant compound of the formula (III): wherein R 1 and R 2 are as defined above, with a dialkyl acetal of N,N-dimethylformamide, (c) reacting the resultant enaminone of the formula (IV): wherein R 1 and R 2 are as defined above, with guanidine or a salt thereof, and then, (d) hydrolizing the cyano group of the resultant compound of the formula (V) wherein R 1 and R 2 are as defined above in acidic conditions, so as to obtain the amide of the formula (I), as defined above in salt form; and, if desired, converting the resultant salt into the free base in basic conditions.