Patent ID: 8138360

Claim:
An amyloid binding compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein Y is H, NO 2 , F, Cl, Br, I, O—(CR″ 2 ) n —X, or —(CR″ 2 ) n -X; wherein X is F, Cl, Br or I; and n is 1-5; R′ is H or a lower alkyl group; R″ is H or a lower alkyl group; R 3 -R 10 are independently selected from the group consisting of H, F, Cl, Br, I, C 1 -C 5 alkyl, (CH 2 ) 1-3 —OR 11 , CF 3 , —(CH 2 ) 1-3 —X, —O—(CH 2 ) 1-3 —X, CN, —CO—R 11 , —N(R 11 ) 2 , —NR″ 3 + , —NO 2 , —CO—N(R 11 ) 2 , —O—(CO)—R 11 , OR 11 , SR 11 , COOR 11 , R ph , —CR 11 ═CR 11 —R ph and —C(R 11 ) 2 —C(R 11 ) 2 —R ph , wherein one or both of R 8 and R 9 are independently OR 11 , and wherein X is F, Cl, Br or I; and R ph is phenyl optionally substituted with one or more substituents selected from the group consisting of F, Cl, Br, I, C 1 -C 5 alkyl, (CH 2 ) 1-3 -OR 11 , CF 3 , —(CH 2 ) 1-3 —X, —O —(CH 2 ) 1-3 —X, CN, —CO—R 11 , —N(R 11 ) 2 , —CO—N(R 11 ) 2 , —O—(CO)—R 11 , OR 11 , SR 11 , and COOR 11 , wherein each R 11 is independently H or C 1 -C 5 alkyl; and Y or R 3 -R 10 comprises at least one detectable label selected from the group consisting of 131 I, 123 I, 124 I, 125 I, 76 Br, 75 Br, 18 F, 19 F, 11 C, 13 C, 14 C and 3 H.