Patent ID: 7101877

Claim:
A compound of formula (I), or a solvate or pharmaceutically acceptable salt thereof: wherein, X is selected from —C(R 6 ,R 14 )—Y—, and —C(R 13 )═CH—; Y is selected from a direct bond, O, S, and C 1 –C 4 alkylene; R 13 is selected from hydrogen, C 1 –C 6 alkyl, C 3 –C 8 cycloalkyl, aryl, and benzyl; R 1 and R 2 taken together with the nitrogen atom to which they are directly attached in formula (I) form a morpholinyl ring where any one or more of the carbon ring atoms may be substituted with one or two substituents selected from hydrogen, hydroxy, C 1 –C 3 hydroxyalkyl, oxo, C 2 –C 4 acyl, C 1 –C 3 alkyl, C 2 –C 4 alkylcarboxy, C 1 –C 3 alkoxy, and C 1 –C 20 alkanoyloxy; R 3 and R 4 are independently attached to the cyclohexane ring shown in formula (I) at the 3-, 4-, 5- or 6-positions and are independently selected from hydrogen, hydroxy, C 1 –C 6 alkyl, and C 1 –C 6 alkoxy; R 5 , R 6 and R 14 are independently selected from hydrogen, C 1 –C 6 alkyl, aryl and benzyl; A is selected from C 5 –C 12 alkyl, a C 3 –C 13 carbocyclic ring, and ring systems selected from formulae (III), (IV), (V), (VI), (VII) and (VIII): where R 7 , R 8 and R 9 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 –C 7 alkanoyloxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, C 2 –C 7 alkoxycarbonyl, C 1 –C 6 thioalkyl and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 –C 6 alkyl; where R 10 and R 11 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 –C 7 alkanoyloxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, C 2 –C 7 alkoxycarbonyl, C 1 –C 6 thioalkyl, and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 –C 6 alkyl; where R 12 is selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 –C 7 alkanoyloxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, C 2 –C 7 alkoxycarbonyl, C 1 –C 6 thioalkyl, and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 –C 6 alkyl; and Z is selected from CH, CH 2 , O, N and S, where Z may be directly bonded to “X” as shown in formula (I) when Z is CH or N, or Z may be directly bonded to R 17 when Z is N, and R 17 is selected from hydrogen, C 1 –C 6 alkyl, C 3 –C 8 cycloalkyl, aryl and benzyl; including isolated enantiomeric, diastereomeric and geometric isomers thereof, and mixtures thereof.