Patent ID: 8575151

Claim:
A process for preparing organic acid addition salts of amine containing pharmaceutically active compounds comprising the steps of: a) dissolving of an amine containing pharmaceutically active compound selected from the group consisting of phentermine, ephedrine, pseudoephedrine and benzphetamine in a suitable solvent; b) preparing a solution comprising pamoate; b) combining the solution of amine containing pharmaceutically active compound, and the solution of pamoic acid to form the reaction mixture; c) warming said reaction mixture; e) allowing said reaction mixture to react; f) isolating said organic acid addition salt of amine containing pharmaceutically active compound by filtration, centrifugation or concentration, and g) drying the isolated or purified material to remove reaction solvent wherein said pharmaceutically acceptable organic acid addition salt of an amine containing pharmaceutically active compound has a phase transition temperature of at least 100° C.