Patent ID: 7846909

Claim:
A method for inhibiting the growth or proliferation, or inducing apoptosis, of a mammalian cell that expresses a MAGE gene selected from the group consisting of MAGE-A2, MAGE-A3, MAGE-A5, MAGE-A6, MAGE-A8, MAGE-A9, MAGE-A10, MAGE-A11, MAGE-A12, MAGE-B1, MAGE-B2, MAGE-B3, MAGE-B4, MAGE-C1, MAGE-C2, Necdin, MAGE-D, MAGE-E1, MAGE-F, MAGE-G, and MAGE-H, the method comprising inhibiting the binding of KAP-1 to a polypeptide encoded by the MAGE gene in the cell, by administering to the cell a substance that inhibits the formation of a complex between KAP-1 and a MAGE protein encoded by the MAGE gene, or the function of the complex, wherein the substance is a short interfering RNA molecule that specifically inhibits the expression of the MAGE gene.