Patent ID: 8268974

Claim:
A method of preparation of a fibrillar protein, comprising: providing an isolated and/or purified globular protein; forming a solution containing the isolated and/or purified globular protein; adding a detergent to the solution containing the isolated and/or purified globular protein, wherein the detergent is one selected from the group consisting of sodium dodecyl sulfate (SDS) and n-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced fibrillar protein formation from the isolated and/or purified globular protein; and eluting the fibrillar protein from the column, wherein the eluted protein has a fibrillar structure.