Patent ID: 8435493

Claim:
A method of synthesizing an amino acid analog of the formula or salt thereof comprising the step of reacting a halogenated compound with a compound of the following formula followed by an acid to yield the amino acid analog R1 is tert-butoxycarbonyl(Boc) or bis(4-methoxyphenyl)methyl in the compound and hydrogen in the amino acid analog; R2 is hydrogen; X is selected from the group consisting of halogen, haloalkyl, halocycloalkyl, halocycloalkenyl, halocycloalkynyl, haloacyl, haloaryl, haloheteroaryl, haloalkenyl, haloalkynyl, where halo or halogen in X is selected from the group consisting of F, Cl, Br, I, At, F-18, Br-76, I-123, I-124; Y is selected from the group consisting of (CR 5 R 6 )n, n=1-4, N, O, S, and Se; R 4 , R 5 and R 6 are independently selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, heteroaryl, aryl, haloaryl, haloheteroaryl, alkenyl, haloalkenyl, alkynyl, and haloalkynyl, where halo is selected from the group consisting of non-radioactive F, Cl, Br, and I; and R 3 is selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, cycloalkynyl, halocycloalkynyl, acyl, haloacyl, aryl, haloaryl, heteroaryl, haloheteroaryl, alkenyl, haloalkenyl, alkynyl, and haloalkynyl.