Patent ID: 7247617

Claim:
A compound having a structure according to formula I and the pharmaceutically acceptable salts thereof, wherein R 2 is CHO or R 3 is H, CH 2 OH, R 4 is MeO or Me; R 5 is H or Me; R 6 is Me or Et; R 7 is H or C 1 -C 4 alkyl; R 8 and R 9 are independently H, (C 1 -C 4 )alkyl, CH 2 OH, or CH 2 O(C 1 -C 4 )alkyl, or R 8 and R 9 combine to form (CHR 10 ) m ; each R 10 is independently H, OH, O(C 1 -C 4 )alkyl, or (C 1 -C 4 )alkyl; Ar is an unsubstituted or substituted aromatic moiety selected from the group consisting of phenyl, wherein a substituted aromatic moiety Ar has one to three substituents independently selected from the group consisting of halo, hydroxy, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, trifluoromethyl, cyano, nitro, C 1 -C 3 alkylamino or dialkylamino, and C 1 -C 3 alkoxy; and Ar 1 is phenyl or phenyl substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, trifluoromethyl, cyano, nitro, C 1 -C 3 alkylamino or dialkylamino, and C 1 -C 3 alkoxy; m is 1, 2, 3, or 4; and n is 0, 1, or 2; subject to a first proviso (I) that when (a) R 1 is other than (b) R 2 is CHO, and (c) R 3 is other than then Ar is other than unsubstituted or substituted phenyl; and a second proviso (II) that when (a) R 1 is H and (b) R 2 is CHO, then R 3 is