Patent ID: 8772268

Claim:
A compound having the formula wherein X is a leaving group; R 1 and R 2 are the same or different and each is selected from the group consisting of H, halogen, alkyl, alkenyl, haloalkyl, aralkyl, heteroaralkyl, aryloxy, arylthio, aminoalkyl, hydroxylalkyl, alkoxyalkyl, hydroxyl, amino, alkylamino, arylamino, heteroarylamino, alkylaminoalkyl, arylaminoalkyl, heteroarylaminoalkyl, alkoxy, alkoxyalkyl, alkylthio, O-acyl, N-acyl, and S-acyl, or R 1 is H, halogen, alkyl, alkenyl, haloalkyl, aralkyl, heteroaralkyl, aryloxy, arylthio, aminoalkyl, hydroxylalkyl, or alkoxyalkyl and R 2 is H, halogen, alkyl, alkenyl, haloalkyl, hydroxyl, amino, alkoxy, alkylthio, O-acyl, N-acyl, or S-acyl; each R 3 is the same or different and is alkyl, hydroxyl, or alkoxy; each R 4 is the same or different and is alkyl, aralkyl, heteroaralkyl or where m is 1, 2, 3, 4, 5, or 6; one of R 5a and R 5b is H or R 7 and the other of R 5a and R 5b is H, halogen, nitro, alkyl, haloalkyl, hydroxyl, amino, alkoxy, alkylthio, O-acyl, N-acyl, S-acyl, or N—O-acyl; and R 7 represents one or more substituents up to the total number of available positions and is hydrogen, halogen, alkyl, haloalkyl, or alkoxy; A is —O—, —S—, —N(R 8 )—, —C═C—; —C═N—, or N═C and R 8 is hydrogen or alkyl; or both R 4 taken together are wherein R 7 and A are defined as above and one of R 6a and R 6b is H or R 7 and the other of R 6a and R 6b is nitro, O-acyl, N-acyl, N—O-acyl or —N═N—R 9 where R 9 is alkyl or aryl; and pharmaceutically acceptable salts thereof.