Patent ID: 8420655

Claim:
A compound of Formula I: or pharmaceutically acceptable salts thereof, wherein: R 1 is selected from wherein indicates a single or double bond; R 2 is —(C 1 -C 6 )alkyl; R 3 , R 4 , R 5 , R 6 and R 7 are each independently selected from (a) —H, (b) —OH, (c) halogen, (d) —CN, (e) —CF 3 , (f) C 1-6 alkyl optionally substituted with one to three —OH, fluorine, C 1-6 alkoxyl-N(R 11 )(R 12 ), or —C(O)N(R 11 )(R 12 ), (g) C 1-8 alkenyl optionally substituted with —CO 2 R 11 , (h) C 1-6 alkoxy optionally substituted with one to three —OH, fluorine, —OC 1-6 alkyl, —OC 3-6 cycloalkyl, —CO 2 H, —CO 2 R 11 , C 3-6 cycloalkyl, C 3-6 heterocyclyl, N(R 11 )(R 12 ), or —C(O)N(R 11 )(R 12 ), (i) —S(O) n C 1-6 alkyl, (j) —SCF 3 , (k) —CO 2 R 11 , (l) —C(O)N(R 11 )(R 12 ), (m) —NH—S(O) 2 —C 1-6 alkyl, (n) —S(O) 2 N(R 11 )(R 12 ), (o)—OCF 3 , (p) —OCHF 2 , (q) a 5-membered heteroaryl group optionally substituted with one to three groups selected from C 1-6 alkyl, C 3-6 cycloalkyl, halogen, —CF 3 , —OH, —(CH 2 ) n CO 2 R 11 , —SCF 3 , —C(O)N(R 11 )(R 12 ), —NH—SO 2 C 1-6 alkyl, C 1-6 alkoxyl, C 1-6 alkyl-O—C 1-3 alkyl, C 1-6 alkylhydroxyl, C 1-3 alkyl-CN, phenyl optionally substituted with halogen and —S(O) n C 1-6 alkyl, with the proviso that one of R 3 , R 4 , R 6 or R 7 must be (q); R 8 , R 9 and R 10 are each independently selected from —H, —OH, —NR 12 R 13 , —NR 12 C(O)C 1-6 alkyl, —CH 2 NH 2 , CO 2 C 1-6 alkyl, —CN, C 1-6 alkyl, —C 1-6 alkoxy, —OC 3-6 cycloalkyl, —SC 1-6 alkyl, —S(O) n alkyl and —CH 2 OH; R 11 , R 12 and R 13 are each independently selected from —H and —(C 1 -C 6 )alkyl, or R 11 and R 12 together with the nitrogen they are bonded to may form a azetidine, piperidine, pyrrolidine, piperazine or morpholine ring; n is 0, 1 or 2.