Patent ID: 8491883

Claim:
A method of treating amyotrophic lateral sclerosis comprising administering by intrathecal injection umbilical cord tissue-derived cells in an amount effective to treat amyotrophic lateral sclerosis to a patient, wherein the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion into culture, have the potential to differentiate into cells of other phenotypes, can undergo at least 40 doublings, and have the following characteristics: (a) expresses each of CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, PD-L2 and HLA-A,B,C; (b) does not express any of CD31, CD34, CD45, CD80, CD86, CD 117, CD141, CD178, B7-H2, HLA-G, or HLA-DR,DP,DQ; and (c) increased expression of interleukin-8; reticulon 1; and chemokine receptor (C-X-C motif) ligand 3, relative to that of a human cell which is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.