Patent ID: 8080642

Claim:
A composition comprising an isolated polynucleotide comprising a nucleic acid fragment which encodes amino acids 1-417 of a SARS-CoV-S1 polypeptide, and a carrier, wherein said nucleic acid fragment is selected from the group consisting of SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 45, SEQ ID NO: 50 and SEQ ID NO: 68 wherein said composition, when administered to a vertebrate in a sufficient amount, elicits a detectable immune response against SARS CoV; and wherein said composition further comprises a component of SARS-CoV selected from the group consisting of inactivated virus, attenuated virus, a viral vector expressing an isolated SARS-CoV virus polypeptide, and an isolated polypeptide from a SARS-CoV virus protein, fragment, variant or derivative thereof and/or one or more additional polynucleotides comprising at least one coding region encoding a SARS-CoV polypeptide, or a fragment, variant, or derivative thereof.