Patent ID: 8802724

Claim:
A compound having the formula wherein R 1 is hydrogen or an OH protecting group, or is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heteroalkyl, heteroalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl, each of which is optionally substituted; R 2 is alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, arylalkyl, or heteroalkyl, each of which is optionally substituted; R P2 is hydrogen, hydroxyl protecting group or a pro -drug forming group; R 3 is alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, arylalkyl, or heteroarylalkyl; Ar is aryl is optionally substituted with a radical —(CH 2 ) X Z x , where x is an integer from 0-6 and Z X is selected from halogen, hydroxy, alkanoyloxy, optionally substituted aroyloxy, alkyl, alkoxy, cycloalkyl, cycloalkoxy, alkenyl, alkynyl, haloalkyl, haloalkoxy, halocycloalkyl, halocycloalkoxy, C 1 -C 6 alkylamino, (C 1 -C 6 alkyl)(C 1 -C 6 alkyl)amino, alkylcarbonylamino, N—(C 1 -C 6 alkyl)alkylcarbonylamino, aminoalkyl, C 1 -C 6 alkylaminoalkyl, (C 1 -C 6 alkyl)(C 1 -C 6 alky)aminoalkyl, alkylcarbonylaminoalkyl, N—(C 1 -C 6 alkyl)alkylcarbonylaminoalkyl, cyano, and nitro or Z X is selected from —CO 2 R 4 and—CONR 5 R 6 , where R 4 , R 5 , and R 6 are each independently selected in each occurrence from hydrogen, C 1 -C 6 alkyl, aryl-C 1 -C 6 alkyl, and heteroaryl-C 1 -C 6 alkyl; or Ar is 3,4-methylenedioxyphenyl; or Ar is heteroaryl which is optionally substituted; and wherein the compound is not