Patent ID: 7226779

Claim:
An adenovirus, comprising adenoviral capsid proteins; and an adenoviral vector comprising adenoviral ITRs flanking a packaging signal and at least a 1.0 kb of a Moloney murine leukemia virus (MoMLV) nucleotide sequence, wherein the at least 1.0 kb MoMLV nucleotide sequence comprises a single MoMLV LTR and a nucleotide sequence encoding a portion of a viral envelope protein, wherein the single MoMLV LTR is operably linked to a nucleic acid sequence of interest, wherein the adenoviral vector does not comprise a nucleic acid encoding the MoMLV gag or pol proteins, wherein the adenoviral vector does not comprise a second MoMLV LTR, and wherein the adenoviral vector is packaged in the adenoviral capsid proteins, thereby producing infective adenovirus, wherein upon infection of an isolated host cell with the adenovirus, the adenoviral vector is integrated into the genome of the isolated host cell.