Patent ID: 8586623

Claim:
A method of treating epilepsy in a mammal comprising administering to the mammal an effective amount of a compound having the structural formula (I) or a geometric isomer, enantiomer, diastereomer, or pharmaceutically acceptable salt thereof, optionally together with a pharmaceutically acceptable carrier or diluent, wherein R 1 is hydrogen; R 2 is hydrogen; R 3 is (a) a substituted or unsubstituted heterocycle selected from the group consisting of imidazo[1,2-a]pyridin-3-yl, imidazo[1,2-a]pyrimidin-3-yl, imidazo[1,2-b][1,2,4]triazin-7-yl, imidazo[1,2-b]pyridazin-3-yl, 5,6,7,8-tetrahydroimidazo[1,2-b]pyridazin-3-yl, imidazo[2,1-b][1,3,4]thiadiazol-5-yl, imidazo[2,1-b][1,3]thiazol-5-yl, 1H-imidazol-4-yl, 1H-imidazol-5-yl, 1H-indo1-2-yl, 1H-indol-3-yl, isoxazol-4-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-pyrazolo[1,5-a]pyrimidin-3-yl, 1H-pyrazolo[3,4-b]pyridin-3-yl, 1H-pyrrolo[2,3-b]pyridin-3-yl, 1H-pyrrolo[2,3-c]pyridin-2-yl, 1H-pyrrolo[2,3-c]pyridin-3-yl, 1H-pyrrolo[3,2-b]pyridin-3-yl, 1H-pyrrolo[3,2-c]pyridin-2-yl, 1H-pyrrolo[3,2-c]pyridin-3-yl, 1,3,4-thiadiazol-2-yl, 1,3-thiazol-5-yl, and indolizin-3-yl; or (b) a substituted or unsubstituted heterocycle selected from the group consisting of 1H-1,2,3-benzotriazol-1-yl, 1H-imidazo[4,5-b]pyridin-1-yl, 3H-imidazo[4,5-b]pyridin-3-yl, 7H-imidazo[4,5-c]pyridazin-7-yl, 1H-indol-1-yl, 2,3-dihydro-1H-indol-lyl, 9H-purin-9-yl, 1H-pyrazolo[3,4-b]pyridin-1-yl, 2H-pyrazolo[3,4-b]pyridin-2-yl, 1H-pyrrolo[2,3-b]pyridin-1-yl, 1H-pyrrolo[3,2-b]pyridin-1-yl, 8H-isothiazolo[5,4-b]indol-8-yl, 1H-1,2,4-triazol-yl, and 1H-pyrrol-1-yl; R 4 is C 1-12 alkyl optionally substituted by halogen or C 1-4 alkoxy; C 2-12 alkenyl optionally substituted by halogen; or C 2-12 alkynyl optionally substituted by halogen; R 5 is hydrogen.