Patent ID: 7666875

Claim:
A compound of formula I: wherein: Q is methylene or ethylene; R 1 is C 1-6 alkoxy, C 1-8 hydroxyalkyl, (C 1-3 alkoxy)C 1-3 alkyl, C 1-3 alkylthio, C 2-5 alkenyl, phenyl, indolyl, quinolyl, pyrazolyl, pyrrolyl, pyridinyl, furyl, N-methylbenzotriazolyl, hydroxyethyl, propenyl, (ethoxycarbonyl)propyl, or tetrahydropyranyloxybutyl, wherein R 1 has (a) 0-3 substituents independently selected from cyano, methyl, methoxy, pyrazolyl, furyl, hydroxyethyl, acetamido, pyrrolyl, and propenyl, and (b) 0-1 substituents selected from benzotriazolyl, N-methyl-benzotriazolyl, and benzo[d][1,3]dioxolyl, T is C═O, —CH 2 —, —CH 2 —CH 2 —, —CH═CH— (cis or trans), propenylene, —CH═CH—CH 2 — (cis or trans), —CH 2 —CH═CH— (cis or trans), ethynylene, or vinylene; R 2 is selected from phenyl, phenoxy, benzyloxy, naphthyl, furyl, isoquinolinyl, quinolyl, indolyl, pyrazolyl, thiazolyl, anthryl, and benzothienyl, wherein R 2 is substituted with 0 to 2 substituents, (a) wherein between 0 and 2 substituents are independently selected from methyl, methoxy, trifluoromethoxy, hydroxyl, hydroxymethyl, fluoro, chloro, bromo, dimethylamino, t-butyl, and isobutoxy; and (b) between 0 and 1 substituents are selected from phenyl, pyridyl, pyrazolyl, furyl, benzoyl, pyrrolyl, pyridinyl, naphthyl, phenoxy, benzo[d][1,3]dioxolyl, cyclohexyl, cyclopentyl, cyclobutyl, and cyclopropyl; X is methylene, ethylene, or propenylene; and R 3 is selected from phenyl, biphenylyl, thiophenyl, bithiophenylyl, diphenylmethanyl, triazolyl, thienyl, benzofuryl, phenanthryl, anthryl, fluorenyl, acenaphthyl, pyrenyl, indanyl, adamantyl, carbazolyl, N-methylcarbazolyl, indolyl, pyrrolidinyl, quinolyl, pyrrolyl, naphthyl, methylnaphthyl, methoxynaphthyl, dimethylthienyl, benzothiadiazolyl, benzimidazolyl, benzothienyl, benzodioxanyl, benzodioxepinyl, benzodioxocinyl, and benzo[d][1,3]dioxolyl, wherein R 3 is substituted with 0 to 4 substituents independently selected from methyl, trifluoromethyl, methoxy, trifluoromethoxy, chloro, fluoro, bromo, ethenyl, ethoxy, ethyl, isopropyl, t-butyl, propyloxy, amino, dimethylamino, methylamino, allyloxy, (methyl)(phenyl)amino, methanesulfonyl, t-butoxycarbonylmethylamino, t-butoxycarbonyl, boronic acid moiety, and methylcarbonylamin; and wherein either R 1 is C 1-6 alkoxy or X is propenylene; or a pharmaceutically acceptable salt thereof.