Patent ID: 7557136

Claim:
A pyrrolidine derivative of Formula I: its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein: R 1 is selected from the group consisting of H and C 1 -C 6 -alkyl; B is selected from the group consisting of —COO, —CONR 4 , oxadiazole, thiadiazole or benzimidazole; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, aryl, C 1 -C 6 -alkyl aryl, heteroaryl, C 1 -C 6 -alkyl heteroaryl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkenyl aryl, C 2 -C 6 -alkenyl heteroaryl, C 2 -C 6 -alkynyl, C 2 -C 6 -alkynyl aryl, C 2 -C 6 -alkynyl heteroaryl, C 3 -C 8 -cycloalkyl, heterocycloalkyl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, C 1 -C 6 -alkyl carboxy, acyl, C 1 -C 6 -alkyl acyl, C 1 -C 6 -alkyl acyloxy, C 1 -C 6 -alkyl alkoxy, alkoxycarbonyl, C 1 -C 6 -alkyl alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkyl aminocarbonyl, C 1 -C 6 -alkyl acylamino, C 1 -C 6 -alkyl ureido, amino, C 1 -C 6 -alkyl amino, sulfonyloxy, C 1 -C 6 -alkyl sulfonyloxy, sulfonyl, C 1 -C 6 -alkyl sulfonyl, sulfinyl, C 1 -C 6 -alkyl sulfinyl, C 1 -C 6 -alkyl sulfanyl, and C 1 -C 6 -alkyl sulfonylamino; R 3 is selected from the group consisting of aryl and heteroaryl; R 4 is selected from the group consisting of H, C 1 -C 6 -alkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, aryl, and heteroaryl; or R 2 and R 4 can form together with the N atom to which they are linked to, a 5-8 membered saturated or unsaturated heterocycloalkyl ring; and n is an integer from 1 to 3.