Patent ID: 6927300

Claim:
A process for the preparation of Latanoprost [1] which comprises deriving the compound [5] to give the compound [7] which is hydrogenated in the presence of catalyst to give the compound of the Formula [9] which is reduced with diisobutylaluminum hydride at temperature range from −50 to +50° C. followed by hydrolysis of the obtained reaction mixture under basic conditions to give compound [11], which is converted into latanoprost [1] wherein one of R 1 and R 2 is an aryl carbonyl and the other one is selected from the group consisting of aryl carbonyl, acyl, trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted and alkyl-substituted tetrahydro-2H-pyran-2-yl and tetrahydrofuran-2-yl groups, and R 3 is hydrogen when R 1 is acyl and is equal to R 1 when it is trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl groups; R 4 is hydrogen when R 2 is acyl and is equal to R 2 when it is trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl groups.