Patent ID: 6930097

Claim:
A method to treat MMPs-related disorders in a mammal in need thereof, comprising administering an inhibitor of MMP activity in a therapeutically effective amount to said mammal, wherein said inhibitor of MMP is selected from a compound of the formula: wherein X is a Zn(II) chelating group and selected from the group consisting of (CH 2 ) n OH, (CH 2 ) n NH 2 , (CH 2 ) n SH, (CH 2 ) m COOH, (CH 2 ) m COOR, (CH 2 ) m CONH 2 , (CH 2 ) m″ CONH—OH, (CH 2 ) m″ CONH—R, and (CH 2 ) n′ O(PO 3 ) m″ (m″+1) , wherein n=2, 3, 4, or 5, n′=2 or 3, m=1, 2, 3, or 4, m′=1, 2, 3, 4, 5, or 6, m″=1, 2, 3, and R=—C m .H 2m′+1 or aryl groups.