Patent ID: 8512677

Claim:
A method of detecting pyro-Glu-(3-40/42)-Aβ in brain tissue of a subject, the method comprising: administering to the subject a molecular probe that includes: (a) a detectable moiety, and (b) an antibody or binding fragment thereof that specifically binds to an N-terminal epitope of pyro-Glu-(3-40/42)-Aβ that includes SEQ ID NO: 3, wherein the antibody or binding fragment thereof comprises at least one of (i) a heavy chain variable domain that includes the amino acid sequences of the three CDRs in SEQ ID NO: 13 and a light chain variable domain that includes the amino acid sequences of the three CDRs in SEQ ID NO: 14, (ii) a heavy chain variable domain that comprises the sequence of SEQ ID NO: 13, (iii) a light chain variable domain that comprises the sequence of SEQ ID NO: 14, or (iv) a heavy chain variable domain that comprises the sequence of SEQ ID NO: 13 and a light chain variable domain that comprises the sequence of SEQ ID NO: 14; and visualizing the molecular probe with an in vivo imaging modality after administration to the subject.