Patent ID: 8207139

Claim:
A method of inhibiting vascular endothelial cell adhesion and leukocyte attachment in acidosis conditions, wherein the inhibition of vascular cell adhesion and leukocyte attachment is achieved by inhibiting the proton-sensing receptor GPR4, in particular, with small interfering RNA molecules that have the nucleotide sequences of: sense: 5′-AUCCCUCUACAUCUUUGUCAU-3′ (SEQ ID NO:1) and antisense: 5′-AUGACAAAGAUGUAGAGGGAU-3′ (SEQ ID NO:2) or sense: 5′-CAAGAGGAACAGCACAGCCAA-3′ (SEQ ID NO:3) and antisense: 5′-UUGGCUGUGCUGUUCCUCUUG-3′ (SEQ ID NO:4).