Patent ID: 7750014

Claim:
A compound of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: wherein Z 1 represents hydrogen, C 1-6 alkyl, benzyl, 4-methoxybenzyl or 3,4-dimethoxybenzyl; R 1 represents in which n represents an integer of 0 to 6; Q 1 represents —NH—, —N(C 1-6 alkyl)-, or —O—; Y represents hydrogen, C 3-8 cycloalkyl optionally substituted by C 1-6 alkyl, C 3-8 cycloalkyl fused by benzene, aryl or heteroaryl, wherein said aryl and heteroaryl are optionally substituted at a substitutable position with one or more substituents selected from the group consisting of cyano, halogen, nitro, guanidino, pyrrolyl, sulfamoyl, C 1-6 alkylaminosulfonyl, di(C 1-6 alkyl)aminosulfonyl, phenyloxy, phenyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 1-6 alkoxycarbonyl, C 1-6 alkanoyl, C 1-6 alkanoylamino, carbamoyl, C 1-6 alkylcarbamoyl, di-(C 1-6 alkyl)carbamoyl, C 1-6 alkylsulfonyl, C 1-6 alkyl optionally substituted by mono-, di-, or tri-halogen, C 1-6 alkoxy optionally substituted by mono-, di-, or tri-halogen and C 1-6 alkylthio optionally substituted by mono-, di-, or tri-halogen, or aryl fused by 1,3-dioxolane; R 2 represents hydrogen or C 1-6 alkyl; R 3 represents hydrogen, halogen, C 1-6 alkyl optionally substituted by mono-, di-, or tri-halogen, C 1-6 alkoxy optionally substituted by mono-, di-, or tri-halogen, in which R 3a and R 3b independently represent C 3-8 cycloalkyl, or C 1-6 alkyl optionally substituted by carboxy, C 3-8 cycloalkyl, carbamoyl, C 1-6 alkylcarbamoyl, aryl-substituted C 1-6 alkylcarbamoyl, C 1-6 alkylcarbamoyl, di(C 1-6 alkyl)carbamoyl, C 3-8 cycloalkylcarbamoyl, C 3-8 heterocyclocarbonyl, C 1-6 alkylamino, di(C alkyl)amino or C 1-6 alkoxy, in which q represents an integer of 1 to 3; R 3c represents hydrogen, hydroxy, carboxy, or C 1-6 alkyl optionally substituted by hydroxy, carboxy or (phenyl-substituted C 1-6 alkyl)carbamoyl; Xa represents —O—, —S— or —N(R 3d )— in which R 3d represents hydrogen or C 1-6 alkyl; and R 4 represents hydrogen or C 1-6 alkyl.