Patent ID: 7858641

Claim:
A compound of formula ID wherein R 1 is an arylalkyl group optionally substituted with one or more substituents independently selected from the group consisting of alkyl, cyano, F, Cl, Br, I, hydroxyl, alkoxy, aryloxy, ester, thiol, alkyl sulfide, aryl sulfide, sulfone, sulfonyl, sulfoxide, amine, amide, alkylamine, dialkylamine, arylamine, alkylarylamine, diarylamine, N-oxide, imide, enamine, trialkylsilyl, dialkylarylsilyl, alkyldiarylsilyl, and triarylsilyl; R 2 and R 3 are each H; R 4 , R 5 , and R 6 are each H; W is a group of formula IIA or IIB; R 1′ and R 2′ , together with the nitrogen to which they are bound, form a piperazine optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, alkyl, cyano, hydroxyl, alkoxy, aryloxy, ester, thiol, alkyl sulfide, aryl sulfide, sulfone, sulfonyl, sulfoxide, amine, amide, alkylamine, dialkylamine, arylamine, alkylarylamine, diarylamine, N-oxide, imide, enamine, trialkylsilyl, dialkylarylsilyl, alkyldiarylsilyl, and triarylsilyl; R 3′ is a cycloalkyl group optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, alkyl, hydroxyl, alkoxy, aryloxy, ester, thiol, alkyl sulfide, aryl sulfide, sulfone, sulfonyl, sulfoxide, amine, amide, alkylamine, dialkylamine, arylamine, alkylarylamine, diarylamine, N-oxide, imide, enamine, trialkylsilyl, dialkylarylsilyl, alkyldiarylsilyl, triarylsilyl, carbonyl, carboxyl, imine, oxime, hydrazone, and nitrile; and R 4′ is H; or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.