Patent ID: 8173639

Claim:
A compound according to formula I wherein A is N, CH or CR 1 ; wherein each R 1 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C(O)—C 1-6 alkyl, —C(O)—C 2-6 alkenyl, —C(O)—C 2-6 alkynyl, —C(O)—O—C 1-6 alkyl, —C(O)—O—C 2-6 alkenyl, —C(O)—O—C 2-6 alkynyl or phenyl, wherein said phenyl, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxyl, haloC 1-6 alkyl, nitro, C 1-6 alkoxy, and NR 2 R 3 ; wherein X is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, cyano, —OR 2 , —O—C(O)R 2 , —OC(O)NR 2 R 3 , —C(O)—NR 2 R 3 , —N(R 2 )C(O)R 3 , —N(R 2 )—C(O)NR 2 R 3 or NR 2 R 3 , or X is a mono-cyclic, bi-cyclic or tri-cyclic moiety having 4-16 ring atoms one of which is nitrogen, and wherein one, two or three additional ring atoms may be a hetero atom selected from N, O and S, and wherein said mono-cyclic, bi-cyclic or tri-cyclic moiety may optionally be substituted with one or more substituents W, wherein W is selected from the group consisting of hydrogen, hydroxy, halogen, cyano, (═O), —O—(CH 2 ) c —O—, wherein c is 2 or 3 (spiro), (CH 2 ) d , wherein d is 5 or 6 (spiro), C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, —C(O)—C 1-6 alkyl, —C(O)—C 2-6 alkenyl, —C(O)—C 2-6 alkynyl, —C(O)—O—C 1-6 alkyl, —C(O)—O—C 2-6 alkenyl, —C(O)—O—C 2-6 alkynyl, —O—C(O)—C 1-6 alkyl, —O—C(O)—C 2-6 alkenyl, —O—C(O)—C 2-6 alkynyl, —C(O)H, COOH; or wherein W is a moiety of the formula —(CH 2 ) a —Y—(CH 2 ) b —Z; wherein each of a and b is independently an integer selected from 0, 1, 2 and 3; wherein Y is a bond, C(O), O, S, —O—C(O), —C(O)—O—, —NR 2 —, —NR 2 —C(O)—, —C(O)—NH—, or S(O) 2 ; wherein Z is hydrogen, C 1-6 alkyl, NR 2 R 3 , cyano or a mono-cyclic or fused bi-cyclic moiety comprising 4 to 12 ring atoms of which optionally one, two or three are hetero atoms selected from amongst N, O, and S, and wherein said mono-cyclic or fused bi-cyclic moiety is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, C 1-6 alkyl, hydroxyl, and C 1-6 alkoxy, pyrazinyl, phenyl, pyridyl, and halogen substituted phenyl; wherein each of R 4 -R 8 , R 9 -R 12 , and R 13 -R 17 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halogen, NR 2 R 3 , hydroxy, cyano, nitro, C 1-6 alkoxy, haloC 1-6 alkyl or hydroxyC 1-6 alkyl; wherein each of R 2 and R 3 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, hydroxyC 1-6 alkyl, haloC 1-6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof.