Patent ID: 7273857

Claim:
A compound of Formula I or a pharmaceutically acceptable salt or prodrug thereof, wherein: X is selected from the group consisting of C H , O, N and S; Z is selected from the group consisting of CH and N; Y is selected from the group consisting of ═O, ═N H and ═S or tautomers thereof; —SPU— is a biradical selected from the group consisting of —(CR 6 R 7 ) n —A— and —C 3-8 -cycloalkyl-, wherein n is 1, 2, 3, 4, or 5; A is absent or an optionally substituted —C 3-8 -cycloalkyl; N together with R 1 and R 2 form a heterocyclic ring wherein said heterocyclic ring is 8-azabicyclo[3.2.1]octane, wherein the heterocyclic ring is substituted with one or more substituents R 4 selected from the group consisting of halogen, C 1-8 -alkyl, C 3-8 -cycloalkyl, C 1-8 -alkoxy, C 1-8 -alkylcarbonyl, C 1-8 -alkylidene, C 2-8 -alkenyl, C 2-8 -alkynyl, C 1-6 -alkyloxyimino, and C 1-6 -alkyloxyamino each of which may be optionally substituted with a substituent R 5 , and wherein at least one of said substituents R 4 is R 4 ′ selected from the group consisting of C 1-8 -alkyl, C 3-8 -cycloalkyl, C 1-8 -alkoxy, C 1-8 -alkylcarbonyl, C 1-8 -alkylidene, each of which may be optionally substituted with a substituent R 5 ; R 5 is selected from the group consisting of hydrogen, halogen, hydroxy, C 1-8 -alkyl, C 1-8 -alkoxy, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 1-8 -alkylcarbonyl, C 1-8 -alkylidene, C 2-8 -alkenyl and C 2-8 -alkynyl; R X may be absent or selected from the group consisting of hydrogen, optionally substituted C 1-8 -alkyl, optionally substituted C 3-8 -cycloalkyl, optionally substituted C 2-8 -alkenyl, optionally substituted C 2-8 -alkynyl, CH 2 —N(R 5 )(R 5 ), CH 2 —OR 5 , CH 2 —SR 5 , and CH 2 —O—C(═O)R 5 ; R 3 may be present 0-4 times and selected from the group consisting of halogen, hydroxy, optionally substituted C 1-8 -alkyl, C 1-8 -alkoxy, optionally substituted C 1-8 -alkylidene, optionally substituted C 2-8 -alkenyl, optionally substituted C 2-8 -alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3-8 -cycloalkyl, optionally substituted C 3-8 -heterocyclyl, and optionally substituted C 1-8 -alkylcarbonyl; and each R 6 and each R 7 optionally and independently selected from the group consisting of hydrogen, halogen, hydroxy, optionally substituted C 1-8 -alkyl, C 1-8 -alkoxy, optionally substituted C 1-8 -alkylidene, optionally substituted C 2-8 -alkenyl, optionally substituted C 2-8 -alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3-8 -cycloalkyl, optionally substituted C 3-8 -heterocyclyl, and optionally substituted C 1-8 -alkylcarbonyl.