Patent ID: 8383608

Claim:
A method for the treatment of a condition selected from cachexia, osteoporosis, sarcopenia, a decline in libido and/or sexual dysfunction, comprising administering an agonist or mixed agonist/antagonist compound or pharmaceutically acceptable salt thereof, wherein said compound is according to Formula Ib: wherein X is O or S; R 1 is selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, and C 1 -C 6 acyl; each of which may optionally be substituted with cyano, one or more halo, hydroxyl, or C 1 -C 6 alkoxy; R 2a is selected from H, P(O)(OH) 2 , and C(O)(CH 2 ) n1 C(O)OH; or R 2a is selected from C 1 -C 6 acyl, and C 3 -C 6 alkenyl; each of which may optionally be substituted with amino, or carboxy; n1 is 0, 1, 2, 3, or 4; each R 2b and R 2c is independently selected from H, and C 1 -C 6 alkyl; or R 2b and R 2c may join together to form a C 3 -C 7 cycloalkyl; R 3a is H, halo, cyano, or nitro; or R 3a is C 1 -C 6 alkyl optionally substituted with halo, cyano, nitro, hydroxyl, or C 1 -C 4 alkoxy; or R 3a is amido optionally substituted with C 1 -C 6 alkyl; each R 3b is independently halo, cyano, or nitro; or each R 3b is independently C 1 -C 6 alkyl optionally substituted with cyano, or halo; or each R 3b is amido optionally substituted with C 1 -C 6 alkyl; each R 4a , and R 4b is independently H, halo, cyano, carboxy or nitro; or each R 4a , and R 4b is selected from C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; each of which may optionally be substituted by one or more halo, or C 1 -C 6 alkoxy; or R 4a and R 4b are joined together to form an 5 or 6-membered cycloalkyl, 5 or 6-membered heterocycloalkyl, 5 or 6-membered aryl, or 5 or 6-membered heteroaryl; R 4c is halo, cyano, or nitro; and m1 is 0, 1, or 2.