Patent ID: 7273882

Claim:
A compound of Formula (Ik); or a stereoisomer thereof wherein R 2 and R 3 are each independently hydrogen, methyl or hydroxymethyl; R 4 is hydrogen, C 1-6 alkyl optionally substituted with C 1-4 alkoxy or thiomethyl; or phenyl optionally substituted with one or more groups selected from halogen, C 1-4 alkyl, C 1-4 alkoxy, nitro and dimethylamino; R 5 is hydrogen, C 1-6 alkyl or phenyl in which said phenyl is optionally substituted with one or more groups selected from halogen, —S(O) 2 methyl, C 1-4 alkyl, C 1-4 alkoxy, dimethylamino, nitro and CF 3 ; X is O, S, NH or NHCH 3 ; R 25 is —C 1-6 alkylNR 28 R 29 ; R 26 and R 27 are each independently C 1-4 alkyl, halogen, CF 3 , cyclopropyl or cyclopropylmethyl; R 28 is hydrogen or C 1-6 alkyl; R 29 is hydrogen, C 1-6 alkyl optionally substituted with OH, halogen, C 1-4 alkoxy, C 1-4 alkylcarboxyl, thien-2-yl or phenoxy; —(CH 2 ) m C 3-6 cycloalkyl optionally substituted with phenyl or C 1-4 alkyl; —(CH 2 ) m phenyl optionally substituted with halogen, hydroxyl or C 1-4 alkoxy; C 2-4 alkylenyl or C 2-4 alkylNR 30 R 31 ; or R 28 and R 29 together with the nitrogen to which they are attached is azetidine, aziridine, piperidine, homopiperidine optionally substituted with thien-2-yl, pyridin-2-yl or 4-dimethylphenyl; pyrrolidine optionally substituted with halogen, C 1-6 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, piperidinomethyl, phenylmethyl, 4-alkoxydihydrophenylmethyl, 4-dimethaminophenyl or indol-2-yl; 4-methoxyphenyl-3-thiomorpholine or N-phenylsulfonylmethylpiperazine; R 30 and R 31 are each independently hydrogen, C 1-4 alkyl, phenyl or acetyl; or R 30 and R 31 together with the nitrogen to which they are attached is 2-N-pyrrolidinonyl, 2-N-methylpyrrolidinyl, pyrrolidinyl or imidazolyl; and m is 0 or 1; or a nontoxic pharmaceutically acceptable salt thereof.