Patent ID: 8716494

Claim:
A compound having the formula: or a pharmaceutically acceptable salt, stereoisomer, rotamer or isotopically enriched variants thereof, wherein R 1 is a member selected from the group consisting of hydroxyl, C 1-8 alkyl, C 2-8 alkenyl, C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 hydroxyalkyl, C 3-8 cycloalkyl, C 3-8 cycloheteroalkyl, C 3-8 cycloalkyl-C 1-3 alkyl, C 3-8 cycloheteroalkyl-C 1-3 alkyl, heteroaryl, heteroaryl-C 1-4 alkyl, aryloxyC 1-4 alkyl, aryl-C 1-2 alkoxy-C 1-4 alkyl, —NR a R b , and R a R b N—C 1-4 alkyl wherein R a and R b are each independently selected from the group consisting of H, C 1-8 alkyl, C 3-8 cycloalkyl, C 1-8 haloalkyl, C 3-8 cycloheteroalkyl, C 1-8 alkoxy-C 1-8 alkyl, mono- or di-(C 1-4 alkyl)amino-C 1-4 alkyl, and C 1-8 hydroxyalkyl, or R a and R b are combined with the nitrogen to which each is attached to form a 4- to 7-membered ring optionally having an additional O or N as a ring member and optionally substituted with from 1 to 4 substitutents selected from the group consisting of hydroxy, halogen, C 1-4 alkyl and C 1-4 haloalkyl; R 2 is a member selected from the group consisting of H, C 1-8 alkyl, and C 2-8 alkenyl; or optionally, R 1 and R 2 are combined to form a four- to six-membered ring fused to the pyrrolidinone ring and having at least one ring vertex heteroatom selected from the group consisting of O, S and N; R 3 is a member selected from the group consisting of H, halogen, C 1-4 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, C 3-8 cycloheteroalkyl, C 3-8 cycloalkyl-C 1-3 alkyl and C 3-8 cycloheteroalkyl-C 1-3 alkyl; R 4 is a member selected from the group consisting of H, halogen, C 1-4 alkyl, C 2-6 alkenyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy, C 1-4 alkoxy-C 1-4 alkyl, C 1-6 haloalkyl, and mono- or di-(C 1-4 alkyl)amino; R 5 is a member selected from the group consisting of CF 3 , halogen, cyano, C 1-4 alkyl, C 2-6 alkenyl, C 1-4 hydroxyalkyl, C 1-5 alkoxy, C 1-4 alkoxy-C 1-4 alkyl, C 1-4 alkoxy-C 1-4 alkoxy, C 3-8 cycloalkyl, C 3-8 cycloalkyloxy, C 3-8 cycloheteroalkyl, C 3-8 cycloheteroalkyl-C 1-3 alkyl and mono- or di-(C 1-4 alkyl)amino; R 6 is a member selected from the group consisting of hydrogen, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 2-6 alkenyl, C 1-4 hydroxyalkyl, C 1-5 alkoxy, C 1-4 alkoxy-C 1-4 alkyl, C 1-4 alkoxy-C 1-4 alkoxy, C 3-8 cycloalkyl, C 3-8 cycloalkyloxy, C 3-8 cycloheteroalkyl, C 3-8 cycloheteroalkyl-C 1-3 alkyl and mono- or di-(C 1-4 alkyl)amino; wherein alkyl, aryl and heteroaryl are unsubstituted forms of the indicated radical, except wherein any ring portions of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , including the optional fused rings, are optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halogen, C 1-4 alkyl, benzyl, oxo and C 1-6 alkoxycarbonyl, and any cycloalkyl and cycloheteroalkyl portions optionally have a double bond between ring vertices.