Patent ID: 6906054

Claim:
A pharmaceutical composition comprising a compound of formula I: wherein: R 1 , R 2 , R 5 , and R 6 are each independently hydrogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyl, (C 1 -C 10 )alkanoyloxy, (C 1 -C 10 )alkoxycarbonyl, aryl, heterocycle, halo, cyano, nitro, —COOR a , —C(═O)NR b R c , —OC(═O)NR b R c , NR b R c , or —S(O) n R d ; or R 1 and R 2 together with the carbon to which they are attached are (C 3 -C 8 )cycloalkyl or a heterocycle, wherein each (C 3 -C 8 )cycloalkyl or heterocycle is optionally substituted with (C 1 -C 10 )alkyl, hydroxy, halo, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyloxy, or (C 1 -C 10 )alkoxycarbonyl or R 5 and R 6 together with the carbon to which they are attached are (C 3 -C 8 )cycloalkyl or a heterocycle, wherein each (C 3 -C 8 )cycloalkyl or heterocycle is optionally substituted with (C 1 -C 10 )alkyl, hydroxy, halo, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyloxy, or (C 1 -C 10 )alkoxycarbonyl; R 3 is hydrogen (C 1 -C 10 )alkyl (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyl, (C 1 -C 10 )alkanoyloxy, (C 1 -C 10 )alkoxycarbonyl, halo, cyano, nitro, aryl, heterocycle, —COOR a , —C(═O)NR b R c , —OC(═O)NR b R c , NR b R c , or —S(O) n R d ; R 4 is hydrogen; A is thio, sulfinyl, or sulfonyl; each n is independently 0, 1, or 2; each R a is independently hydrogen, or (C 1 -C 10 )alkyl; each R b and R c is independently hydrogen, (C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy, phenyl, benzyl, phenethyl, or (C 1 -C 10 )alkanoyl; each R d is independently (C 1 -C 10 )alkyl, (C 1 -C 10 )alkanoyl, aryl, heterocycle, aryl(C 1 -C 6 )alkyl, heterocycle, or heterocycle(C 1 -C 6 )alkyl; wherein any (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 10 )alkoxy, (C 1 -C 10 )alkanoyl, (C 1 -C 10 )alkanoyloxy, or (C 1 -C 10 )alkoxycarbonyl of R 1 , R 2, R 3, R 5, and R 6 is optionally substituted with one or more substituents independently selected from halo, hydroxy, cyano, cyanato, nitro, mercapto, oxo, aryl, heterocycle, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, aryl(C 1 -C 6 )alkanoyloxy, halo(C 1 -C 6 )alkanoyloxy, heterocycle(C 1 -C 6 )alkanoyloxy, aryloxy, (heterocycle)oxy, —COOR a , (C 3 -C 8 )cycloalkyl, —C(═O)NR b R c , —OC(═O)NR b R c , NR b ,R c , and —S(O) n R d ; and wherein any aryl is optionally substituted with one or more substituents independently selected from halo, hydroxy, cyano, trifluoromethyl, nitro, trifluoromethoxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, (C 1 C 6 )alkoxycarbonyl, —COOR a , —C(═O)NR b R c , —OC(═O)NR b R c , NR b R c , and —S(O) n R d ; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier; and a β-lactam antibiotic.