Patent ID: 7033604

Claim:
An ophthalmic composition for ocular administration comprising active ingredients, and wherein the active ingredients consist of an interleukin 2 inhibitor and an antimicrobial agent, and wherein the interleukin 2 inhibitor is a tricyclo compound as shown by the following general formula (I) or pharmaceutically acceptable salt thereof: wherein adjacent pairs of R 1 and R 2 , R 3 and R 4 , and R 5 and R 6 each independently a) are two adjacent hydrogen atoms, wherein R 2 is optionally alkyl, or b) form another bond optionally between carbon atoms binding with the members of said pairs; R 7 is hydrogen atom, hydroxy, alkyloxy or protected hydroxy or may form oxo with R 1 ; R 8 and R 9 each independently are hydrogen atom or hydroxy; R 10 is hydrogen atom, alkyl, alkenyl, alkyl substituted by one or more hydroxy, alkenyl substituted by one or more hydroxy or alkyl substituted by oxo; X is oxo; Y is oxo, (hydrogen atom, hydroxy), (hydrogen atom, hydrogen atom), or a group of the formula N—NR 11 R 12 or N—OR 13; R 11 and R 12 each independently are hydrogen atom, alkyl, aryl or tosyl; R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 22 and R 23 each independently are hydrogen atom or alkyl; R 24 is an optionally substituted ring that may contain one or more heteroatom(s); and n is 1 or 2; wherein Y, R 10 and R 23 may show, together with the carbon atom they bind with, a saturated or unsaturated 5 or 6-membered heterocyclic group containing nitrogen atom, sulfur atom and/or oxygen atom, wherein the heterocyclic group may be optionally substituted by one or more group(s) selected from the group consisting of alkyl, hydroxy, alkyloxy, benzyl, a group of the formula —CH 2 Se(C 6 H 5 ), and alkyl substituted by one or more hydroxyl; and wherein the antimicrobial agent is a quinolone antimicrobial agent.