Patent ID: 6870033

Claim:
A conjugate consisting essentially of an antibody fragment covalently modified by one or two nonproteinaceous polymer molecules at a free sulfhydryl group of a cysteine residue within the hinge region of the antibody fragment, wherein (a) the apparent molecular weight of the conjugate, as determined by size exclusion chromatography, is at least about 500 kD, (b) the average actual molecular weight of each nonproteinaceous molecule is at least 20 kD, and (c) the antibody fragment has an antigen binding site that binds human interleukin-8 (IL-8) comprising an anti-IL-8 monoclonal antibody light chain sequence comprising amino acids 1-219 of the humanized antibody light chain 6G4.2.5v11 (SEQ ID NO: 51).