Patent ID: 8846655

Claim:
A compound of Formula I wherein R 1 is selected from the group consisting of i) phenyl optionally substituted with one to two substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, di(C 1-4 alkyl)aminocarbonyl, chloro, and fluoro; such that only one di(C 1-4 alkyl)aminocarbonyl is present; ii) naphthyl; iii) pyridinyl optionally substituted with one substituent selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, fluoro, chloro, and cyano; iv) pyrimidin-5-yl; v) furanyl; vi) thienyl; vii) 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; and viii) di(C 1-2 alkyl)aminocarbonyl; with the proviso that when R 1 is 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, Y is a bond; Y is ethyl, vinyl, or a bond; or, Y is O when R 1 is an optionally substituted phenyl; R 2 is phenyl optionally substituted with one to two substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, fluoro, chloro, cyano, trifluoromethoxy, and hydroxy; or, R 2 is phenyl substituted with one aminocarbonyl, di(C 1-4 alkyl)aminocarbonyl, C 1-4 alkoxycarbonyl, or carboxy substituent; R 3 is selected from the group consisting of i) 3-amino-cyclohexyl; ii) 4-amino-cyclohexyl; iii) piperidin-3-yl; iv) piperidin-4-yl; v) pyrrolidin-2-ylmethyl wherein pyrrolidin-2-yl is optionally substituted at the 3- or 4- position with one to two fluoro substituents; vi) azetidin-3-ylmethyl; vii) 2-(N-methylamino)ethyl; viii) 3-hydroxy-2-amino-propyl; ix) piperidin-3-ylmethyl; x) 1-azabicyclo[2.2.2]octan-3-yl; and xi) 8-azabicyclo[3.2.1]octan-3-yl; or, R 3 is taken with R a and the nitrogen atom to which they are both attached to form piperazinyl optionally substituted with 4-C 1-4 alkyl; R a is hydrogen, 2-(N-methylamino)ethyl, or C 1-2 alkyl optionally substituted with azetidin-3-yl; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.