Patent ID: 8114416

Claim:
An isolated selected Coxsackie A21 virus capable of lytically infecting or inducing apoptosis in a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1), wherein the selected virus comprises: (i) a capsid protein encoded by the nucleotide sequence of SEQ ID NO: 7, or (ii) a variant capsid protein encoded by a variant of the nucleotide sequence of SEQ ID NO: 7, the variant capsid protein comprising: (a) VP3 H96 or a conservative variation thereof wherein the conservative variation includes K, or (b) VP3 A101 or a conservative variation thereof wherein A101 is substituted by an amino acid selected from the group consisting of G, T, S, and M, or (c) both (a) and (b).