Patent ID: 7138420

Claim:
A compound of the formula (I): wherein: R 1 is hydrogen or alkyl; R 2 is chosen from aryl and heteroaryl, each R 2 is optionally substituted with one or more R a ; R 3 is C 1-10 alkyl chain branched or unbranched optionally substituted with one or more R b , or R 3 is the group: —(CH 2 ) n -L-R 6 , wherein L is chosen from a bond, —NH—C(O)—, —O—C(O)—, —C(O)— and —S(O) m — wherein m is 0, 1 or 2, and wherein said group is optionally substituted by one or more R b ; wherein R 6 is independently chosen from hydrogen, hydroxy, alkyl, alkoxy, alkylthio, arylC 0-5 alkyl, aryloxyC 0-5 alkyl, heteroarylC 0-5 alkyl, cycloalkylC 0-5 alkyl, heterocyclylC 0-5 alkyl and amino said amino is optionally mono-or di-substituted by acyl, alkyl, alkoxycarbonyl, cycloalkylC 0-5 alkyl, arylC 0-5 alkyl, heteroarylC 0-5 alkyl or heterocyclylC 0-5 alkyl; n is 1–10; R 4 is wherein R 4 is covalently attached at the indicated 5- or 6-position of the formula (I), t is 0, R 5 is chosen from arylC 0-5 alkyl, alkyl, heteroarylC 0-5 alkyl, cycloalkylC 0-5 alkyl and heterocyclylC 0-5 alkyl, each R 5 is optionally substituted with one or more R c ; R 7 is hydrogen, alkenyl or alkyl; or R 5 and R 7 together with the nitrogen atom to which they are attached form: a 4–7-membered monocyclic ring or an 8–14-membered bicyclic ring, wherein each monocyclic or bicyclic ring optionally contains an additional 1 to 3 heteroatoms chosen from N, O and S and each ring is aromatic or nonaromatic, and wherein each monocyclic or bicyclic ring is optionally substituted by one or more R c ; each R a , R b or R c are independently chosen from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, aryloxy, alkoxy, alkylthio, acyl, alkoxycarbonyl, acyloxy, acylamino, sulphonylamino, aminosulfonyl, alkylsulfonyl, carboxy, carboxamide, oxo, hydroxy, halogen, trifluoromethyl, nitrile and amino optionally mono-or -di-substituted by alkyl, acyl or alkoxycarbonyl, wherein any of the above R a , R b or R c are optionally halogenated where possible; R d , covalently attached at the indicated 4-, 5-, 6- or 7-position of the formula (I), is chosen from hydrogen, alkyl, alkoxy and halogen and X a and X b are oxygen or sulfur; or the pharmaceutically acceptable salts, esters, acids, isomers or tautomers thereof.