Patent ID: 8618169

Claim:
A pharmaceutical composition comprising, as an active ingredient, a compound having the general Formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is an A-G(â•K)â€”Xâ€”Y group, and wherein: A is alkyl or absent; G is C; K is selected from the group consisting of O and S; X is NRb; and Y is selected from the group consisting of an unsubstituted hydroxyalkyl, and a substituted or unsubstituted polyalkylene glycol residue, R 1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl or aryl; each of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, amino and â€”NR 15 R 16 , or, alternatively, at least two of R 2 , R 3 , R 4 , R 5 and R 6 , of R 7 , R 8 , R 9 and R 10 and/or of R 11 , R 12 , R 13 , and R 14 form a five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring; R 15 and R 16 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl and sulfonyl, or, alternatively R 15 and R 16 form a five- or six-member heteroalicyclic ring; and each of Ra, Rb and Rc is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl, wherein when Y is a polyalkylene glycol residue, said polyalkylene glycol residue does not include a â€”ONO 2 group or an antioxidant residue, and a pharmaceutically acceptable carrier, the composition being packaged in a packaging material and identified in print, in or on said packaging material, for use in increasing a current amplitude of a voltage-dependent potassium channel which comprises a KCNQ2 channel and/or a KCNQ3 channel and/or a KCNQ2/3 channel, said increasing said current amplitude comprising administering the pharmaceutical composition to a subject in need thereof.