Patent ID: 8436013

Claim:
A method of healing, alleviating, relieving, altering, remedying, ameliorating, improving, or affecting alpha-1 antitrypsin (AAT) deficiency in a subject in need of such treatment, the method comprising administering to the subject a compound capable of disrupting polymerization of the mutant Z form of AAT under conditions such that AAT deficiency is treated, wherein the compound is selected from the group consisting of: 5-(2-Bromo-ethoxy-methyl)-auinolin-8-ol, 3,4-methylenedioxy-6-nitrocinnamic acid, 5-Nitro-1-naphthol, 3′-acetoxy acetophenone, 2-Ethyl-3-methyl-3-thiophen-2-yl-oxirane-2-carboxylic acid, sodium salt, 2-Bromo-1,5-dimethoxy-3-methyl -benzene, 2-acetyl-5-chlorothiophene, or 1,9-decadiene; or a pharmaceutically acceptable salt thereof.