Patent ID: 7494975

Claim:
A composition comprising: a polyanion selected from the group consisting of heparin, heparan sulphate, and a polyanion equivalent to heparin or heparan sulphate selected from the group consisting of dextran sulphate, curdian sulphate, 2-naphthalene sulphonate polymer, pentosan polysulphate and resobene, said polyanion having a degree of polymerization dp of 10 to 24, and a CD4 peptide of according to formula (I): (Cys or TPA)-P 1 -Cys-P 2 -Cys-P 3 -Cys-(Ala or Gln)-(Gly or (D)Asp or Ser)-(Ser or His or Asn)-Xaa J -Cys-(Thr or Ala)-Cys-Xaa k -NH 2 (I) wherein TPA represents thiopropionic acid, Xaa J represents β-naphthylalanine or biphenylalanine, Xaa k represents Gly, Val or Ile, P 1 represents 3 to 6 amino acids, P 2 represents 2 to 4 amino acids and P 3 represents 6 to 10 amino acids, the amino acids in P 1 , P 2 and P 3 being natural or unnatural, identical or different, and P 1 , P 2 and P 3 optionally having a common sequence, said CD4 peptide sequence according to formula (I) having a β-hairpin conformation wherein the β-turn comprises the amino acid residues (Ala or Gln)-(Gly or (D)Asp or Ser)-(Ser or His or Asn)-Xaa J .