Patent ID: 8420779

Claim:
A composition of matter of the formula (F 1 ) a —X 2 and multimers thereof, wherein: F 1 is a half-life extending moiety, and a is 1; X 2 is D-(L) c -(P 5 ) d —(X 3 ) e , (X 4 ) f —(P 5 ) d -(L) c -D, or (X 4 ) f —(P 5 ) d -(L) c -D-(L) g -(P 6 ) h —(X 3 ) i , wherein c and g are each independently 0 or 1, d and h are 1, and e, f, and i are each independently 0, 1, 2, 3, or 4; X 3 is -(L) j -(P 7 ), j is 0 or 1; X 4 is (P 8 )-(L) k -, k is 0 or 1; D is a pharmacologically inactive protein domain of human origin, wherein said pharmacologically inactive protein domain is a SH3 domain that comprises a native human amino acid sequence that is an intracellular proline motif (PxxP) recognition and binding domain, and (i) has a mass of 3 kDa to 20 kDa, and (ii) characteristically forms protein aggregates of less than 10 percent of total mass of protein when suspended without other proteins in a pharmaceutically acceptable formulation buffer of interest not comprising a detergent or chaotropic agent; P 5 , P 6 , P 7 and P 8 are each independently a selected pharmacologically active protein of interest 5 to 80 amino acid residues in length; and L is in each instance a peptidyl linker.