Patent ID: 8840930

Claim:
A method for setting the performance characteristics of a pharmaceutical composition for inhalation, comprising the steps of: a) providing a first preblend and a second preblend each containing a mixture of an active pharmaceutical ingredient and a suitable excipient, wherein the excipient in the first preblend has a d50 value of about 125-145 μm and the excipient in the second preblend has a d50 value of about 50-100 μm, and wherein the d50 value of the excipient in the first preblend differs from the d50 value of the excipient in the second preblend by more than 20%; b) mixing the first preblend and the second preblend; and c) introducing the mixture in a suitable delivery device capable of delivering the medicament fraction to the pulmonary system of a patient, wherein the weight ratio of the excipients in the first preblend and the second preblend is set between 1-5, and wherein each of the excipients in the first preblend and the second preblend is a lactose.