Patent ID: 8178677

Claim:
A compound of the Formula I: wherein: m is 0 or 1; n is 1 or 2; R is selected from the group consisting of C 1-10 alkyl, C 1-10 alkoxy, halogen, and C 1-10 haloalkyl; R 1 is selected from the group consisting of: —X—Y—R 4 , —X—R 5 , and —X-Het; X is straight chain or branched chain alkylene optionally interrupted by one —O— group; Y is selected from the group consisting of —S(O) 0-2 — and —N(R 8 )-Q-; R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, arylalkylenyl, heteroaryl, and heteroarylalkylenyl, wherein the alkyl, alkenyl, aryl, arylalkylenyl, heteroaryl, and heteroarylalkylenyl, groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclyl, amino, alkylamino, dialkylamino, and in the case of alkyl and alkenyl, oxo; R 5 is selected from the group consisting of: Het is selected from the group consisting of tetrahydropyranyl and tetrahydrofuranyl; R 6 is selected from the group consisting of ═O and ═S; R 7 is C 2-7 alkylene; R 8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, hydroxyalkylenyl, arylalkylenyl, and heteroarylalkylenyl; R 10 is C 3-8 alkylene; A is selected from the group consisting of —O—, —C(O)—, —CH 2 —, —S(O) 0-2 —, and —N(Q-R 4 )—; Q is selected from the group consisting of a bond, —C(R 6 )—, —S(O) 2 , —C(R 6 )—N(R 8 )—, —S(O) 2 —N(R 8 )—, —C(R 6 )—O—, and —C(R 6 )—S—; and a and b are independently integers from 1 to 6 with the proviso that a+b is <7; with the proviso that when Y is —S(O) 0-2 — then X can not contain an —O— group; or a pharmaceutically acceptable salt thereof.