Patent ID: 7435822

Claim:
A compound of formula (I) Wherein HET is a 5-membered cyclic heteroalkanyl containing 1-2 heteroatoms independently selected from the group consisting of N, O and S; a 6-membered cyclic heteroalkanyl containing 1-3 heteroatoms independently selected from the group consisting of N, O and S; a 5-membered heteroaryl containing 1-2 heteroatoms independently selected from the group consisting of N, O and S; or a 6-membered heteroaryl containing 1-3 heteroatoms independently selected from the group consisting of N, O and S; wherein the point of attachment of HET to the rest of the molecule is through a ring carbon atom; X and Y are one to three substituents independently selected from the group consisting of hydrogen, C 1-6 alkanyl, C 2-6 alkenyl, C 1-6 alkanyloxy, amino, C 1-6 alkanylamino, di(C 1-6 alkanyl)amino, C 1-6 alkanylcarbonyl, C 1-6 alkanylcarbonyloxy, C 1-6 alkanyloxycarbonyl, C 1-6 alkanylcarbonylamino, C 1-6 alkanylthio, C 1-6 alkanylsulfonyl, halogen, hydroxy, cyano, hydroxycarbonyl, tetrazolyl, fluoroalkanyl and fluoroalkanyloxy; or X and Y taken together may form a bridge of 1 or 2 atoms selected from the group consisting of O, S, CH 2 and —N(R 2 )— wherein R 2 is C 1-6 alkyl; R 1 is selected from the group consisting of hydrogen, C 1-8 alkanyl, halo 1-3 (C 1-8 )alkanyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkanyl,cycloalkanyl(C 1-8 )alkanyl, C 1-8 alkanyloxy(C 1-8 )alkanyl, C 1-8 alkanylthio(C 1-8 )alkanyl, hydroxyC 1-8 alkanyl, formyl, thioformyl, carbamimidoyl, phenylimino(C 1-8 )alkanyl, phenyl(C 1-8 )alkanyl, phenyl(C 1-8 )alkenyl, phenyl(C 1-8 )alkynyl, naphthyl(C 1-8 )alkanyl and heteroaryl(C 1-8 )alkanyl; wherein phenyl, naphthyl and heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of C 1-6 alkanyl, C 2-6 alkenyl, C 1-6 alkanyloxy, amino, C 1-6 alkanylamino, di(C 1-6 alkanyl)amino, C 1-6 alkanylcarbonyl, C 1-6 alkanylcarbonyloxy, C 1-6 alkanylcarbonylamino, C 1-6 alkanylthio, C 1-6 alkanylsulfonyl, halogen, hydroxy, cyano, fluoroalkanyl, thioureido, and fluoroalkanyloxy; alternatively, when phenyl and heteroaryl are optionally substituted with two substituents attached to adjacent carbon atoms, the two substituents can together form a single fused moiety; wherein the fused moiety is selected from the group consisting of —(CH 2 ) 3-5 — and —O(CH 2 ) 1-3 O—; and pharmaceutically acceptable enantiomers, diastereomers and salts thereof.