Patent ID: 7820201

Claim:
A dosage form comprising: a first end cap; a second end cap; and a three-dimensionally printed radially-nested region in contact with and axially extending between the first end cap and the second end cap, the radially-nested region comprising: an innermost region comprising a first regional concentration of at least one Active Pharmaceutical Ingredient; and plural three-dimensionally printed non-innermost regions in radially-nested arrangement about the innermost region and comprising: a) one or more radially-nested internal regions each comprising a respective regional concentration of at least one Active Pharmaceutical Ingredient, wherein an internal region radially surrounds and is in radial contact with the innermost region, and any other internal region present radially surrounds another internal region located to the interior thereof; and b) an outermost region radially surrounding an internal region and comprising a respective regional concentration of at least one Active Pharmaceutical Ingredient, wherein the internal and outermost regions are in radially-nested arrangement, the regional concentration of Active Pharmaceutical Ingredient in a region is different from the regional concentration of Active Pharmaceutical Ingredient in another region adjacent to it, the regional concentration of Active Pharmaceutical Ingredient in an internal region is non-zero, the regional concentration of Active Pharmaceutical Ingredient in plural regions is non-zero, and the respective regional concentrations are selected so that the at least one Active Pharmaceutical Ingredient is released according to an approximately zero-order release profile after exposure of the dosage form to an aqueous environment of use.