Patent ID: 7928092

Claim:
A pharmaceutical composition comprising: a salicylate and/or salicylic acid chosen from 5-amino salicylic acid, pharmaceutically acceptable salts and esters thereof, and pro-drugs thereof; at least one pharmaceutically acceptable excipient; and a polymer system chosen from (a) at least one of methyl cellulose and hydroxypropylmethylcellulose in combination with ethyl cellulose, and (b) at least two ammonio methacrylate co-polymers; wherein the composition is formulated as a modified-release pharmaceutical composition with a modified-release matrix core, wherein the composition exhibits a drug-release profile that is independent of surrounding pH and wherein the composition exhibits the following dissolution profile, when tested in a U.S.P. Type II apparatus (paddles) at 37° C. and 50 rpm, in pH 6.8 buffer for the test: 1 hour: less than or equal to about 10% drug released; 2 hours: from about 0 to about 35% drug released; 3 hours: from about 10 to about 60% drug released; 4 hours: from about 20 to about 60% drug released; 6 hours: from about 40 to about 80% drug released; and 12 hours: from about 75 to about 100% drug released.