Patent ID: 7759079

Claim:
A method for optimizing therapy in an individual having inflammatory bowel disease (IBD) and receiving a course of therapy for the treatment of IBD, said method comprising: (a) obtaining a biological sample from said individual; (b) measuring a concentration level of at least one marker selected from the group consisting of an anti-neutrophil cytoplasmic antibody (ANCA), anti- Saccharomyces cerevisiae immunoglobulin A (ASCA-IgA), anti- Saccharomyces cerevisiae immunoglobulin G (ASCA-IgG), an anti-outer membrane protein C (anti-OmpC) antibody, an anti-I2 antibody, and an anti-flagellin antibody in said sample obtained from said individual; (c) applying a logistic regression algorithm to the measured concentration level of said at least one marker to calculate an index value for said individual; (d) comparing the index value calculated from step (c) to an index value for said individual that was calculated at an earlier time during said course of therapy; and (e) determining a subsequent dose of said course of therapy for said individual based upon said comparison from step (d), wherein a higher index value calculated from step (c) indicates a need to increase the subsequent dose of said course of therapy.