Patent ID: 7160872

Claim:
A method for ameliorating a disorder modulated by the CXCR4 chemokine receptor in a subject which method comprises administering to a subject in need of such treatment an effective amount of a compound of formula (I), V—CR 1 R 2 —Ar—CR 3 R 4 —N(R 5 )—(CR 6 R 7 ) x —R 8 (I) wherein V is a 1,4,8,11-tetraazacyclotetradecanyl group, and which may optionally comprise a fused aromatic or heteroaromatic ring; R 1 to R 7 are independently hydrogen, or straight, branched or cyclic C 1-6 alkyl; R 8 is a heterocyclic group, a substituted aromatic group, or a mercaptan group; Ar is an aromatic ring or heteroaromatic ring each said ring being optionally substituted; x is 1 or 2; or the acid addition salts and metal complexes thereof, or a pharmaceutically acceptable composition thereof; wherein said disorder comprises a deficiency in vascularization of the gastrointestinal tract, hematopoiesis, or cerebellar development; abnormal basal leukocyte trafficking; abnormal extravasation and tissue infiltration of leukocytes in response to inciting antigens; or abnormal calcium ion transport.