Patent ID: 7851619

Claim:
A process for the preparation of Eplerenone comprising: (a) epoxidation of trienone IV: with hydrogen peroxide and trichloroacetonitrile in a solvent, thereby forming a reaction mixture; (b) treatment, in the presence of a base, of the reaction mixture with a derivatizing agent selected from the group consisting of [R′OC(O)] 2 , [R′C(O)] 2 , R′C(O)X, and R″S(O) 2 X, wherein R′ is selected from the group consisting of C1 to C6 alkyl, aryl and aralkyl, R″ is selected from the group consisting of C1to C6 alkyl and aryl, and X is a halogen; and (c) precipitation of Eplerenone.