Patent ID: 8809395

Claim:
A compound of formula (IA2): wherein the dotted line between C 10 and C 11 represents an optional double bond; R 1 is selected from the group consisting of substituted C1-C10alkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C4-C8cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —(C0-C10)C(O)R 10 , —(C0-C10)C(O)OR 10 , —(C0-C10)OC(O)R 10 , —(C1-C10)SR 10 , —(C0-C10)C(O)NR 11 R 12 , —(C0-C10)C(O)NHNR 11 R 12 and —(C1-C10)OR 10 ; wherein R 10 , R 11 and R 12 independently from each other are selected from the group consisting of H, substituted or unsubstituted C1-C10alkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C4-C8cycloalkenyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; R 2 , R 3 , R 4 , R 7 , R 8 and R 9 independently from each other are selected from the group consisting of H, substituted or unsubstituted C1-C10alkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C4-C8cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —CN, —(C1-C10)OH, —NR 11 R 12 , —(C0-C10)C(O)R 10 , —(C0-C10)C(O)OR 10 , —(C0-C10)OC(O)R 10 , —(C1-C10)SR 10 , —(C0-C10)C(O)NR 11 R 12 , —C(O)NHNR 11 R 12 and —(C0-C10)OR 10 ; wherein R 10 , R 11 and R 12 independently from each other are selected from the group consisting of H, substituted or unsubstituted C1-C10alkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C4-C8cycloalkenyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; or a pharmaceutically salt thereof or solvate thereof or a prodrug thereof; excluding the following compounds and Z- or E-isomers thereof: