Patent ID: 8609676

Claim:
A compound of Formula (I) Formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: X 1 is a covalent bond; R 1 is substituted aryl, wherein when said substituted aryl has substituents on adjacent carbon atoms, said substituents can optionally be taken together with the carbon atoms to which they are attached to form a first five- or six-membered cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein when said first five- or six-membered cycloalkyl, heterocyclyl, aryl or heteroaryl has substituents on adjacent carbon atoms, said substituents can optionally be taken together with the carbon atoms to which they are attached to form a second five- or six-membered cycloalkyl, heterocyclyl, aryl or heteroaryl; X 2 is —O—; R 2 is H; X 3 is —NH—; R 3 is selected from the group consisting of substituted aryl, substituted heteroaryl, or isoquinoline wherein when each of said substituted aryl, substituted heteroaryl, or isoquinoline has substituents on adjacent carbon atoms, said substituents can optionally be taken together with the carbon atoms to which they are attached to form a first five- or six-membered cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein when said first five- or six-membered cycloalkyl, heterocyclyl, aryl or heteroaryl has substituents on adjacent carbon atoms, said substituents can optionally be taken together with the carbon atoms to which they are attached to form a second five- or six-membered cycloalkyl, heterocyclyl, aryl or heteroaryl; and R 4 is selected from the group consisting of H alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl.