Patent ID: 7893269

Claim:
A process for the manufacture of a compound of formula I: comprising: reacting one or more acid chloride formation reagents with a compound of formula III: thereby forming an intermediate; and reacting the intermediate with an amine R 3 R 6 NH to give the compound of formula I, wherein: R 1 is selected from the group consisting of hydrogen and C 1 -C 6 alkyl; R 2 is selected from the group consisting of C 1 -C 6 alkyl and C 3 -C 6 cycloalkyl; R 3 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, hydrogen and C 1 -C 6 alkyl-[C 3 -C 6 cycloalkyl] with the attachment at the alkyl group; R 4 is selected from the group consisting of hydrogen and C 1 -C 6 alkyl; R 5 is selected from the group consisting of hydrogen, benzyl, a substituted benzyl group, and an alcohol protective group removable using acid/base hydrolysis or catalytic hydrogenation, wherein the substituted benzyl is substituted with 1 to 3 substituents selected from halo, C 1 -C 4 alkyl and C 1 -C 4 alkoxy; R 6 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl and hydrogen; or R 3 R 6 N when taken together form an unsubstituted or substituted heterocyclic ring selected from the group consisting of piperidinyl, morpholinyl, pyrrolidinyl and piperazinyl, wherein the substituted heterocyclic ring is substituted with one to three C 1 -C 6 alkyl groups; R 7 is selected from the group consisting of benzyl, a substituted benzyl, and an alcohol protective group removable using acid/base hydrolysis or catalytic hydrogenation, wherein the substituted benzyl is substituted with 1 to 3 substituents selected from the group consisting of halo, C 1 -C 4 alkyl and C 1 -C 4 alkoxy; and provided that, when R 5 is hydrogen, R 7 is an alcohol protective group removable by acid/base hydrolysis or catalytic hydrogenation and R 7 is removed by acid/base hydrolysis or catalytic hydrogenation after reacting the intermediate with the amine.