Patent ID: 7754243

Claim:
A process comprising: dissolving a biologically active material into a solvent to form a non-aqueous solution, wherein the biologically active material displays little or no aqueous solubility, the non-aqueous solution consisting essentially of the biologically active material and the solvent; compressing and heating the solution to form a supercritical solution; rapidly expanding the supercritical solution through a nozzle into an aqueous solution, wherein the aqueous solution comprises a stabilizing agent in an amount less than the critical micelle concentration of the stabilizing agent; forming a particulate suspension in the aqueous solution, wherein the ratio of biologically active material to stabilizing agent in the particulate suspension is between 1:1 and about 4:1, wherein all of the particles formed in the aqueous suspension comprise the biologically active material, at least about 95% of the particles are less than 100 nm in size, and the particle size distribution standard deviation of all of the particles formed in the aqueous solution is less than about 15 nm.