Patent ID: 8313929

Claim:
A method for improving production of a product of interest in a liquid culture of actinomycetes, the method comprising: introducing into the actinomycetes an agent for altering morphology of microstructures of the actinomycetes, wherein said agent comprises a gene selected from the group consisting of: SsgB (SEQ ID NO:9), SsgC (SEQ ID NO:15), SsgD (SEQ ID NO:13), SsgF (SEQ ID NO: 12), a functional fragment of SsgB comprising at least amino acids 23-34 and at least amino acids 51-71 of SEQ ID NO:9, a functional fragment of SsgC comprising at least amino acids 24-35 and at least amino acids 52-72 of SEQ ID NO: 15, a functional fragment of SsgD comprising at least amino acids 23-34 and at least amino acids 54-74 of SEQ ID NO: 13, a functional fragment of SsgF comprising at least amino acids 37-48 and at least amino acids 65-85 of SEQ ID NO: 12, or any combination thereof.