Patent ID: 8299072

Claim:
A compound selected from the group consisting of pyrazolylmethylamine-piperazine derivatives represented by the following formula 1 and their pharmaceutically acceptable salts thereof, wherein Y represents —(CH 2 ) n —C(O)—; or —C(O)—(CH 2 ) n —, wherein n is an integer of 1-4; R 1 and R 2 , which may be same or different, respectively represent a hydrogen atom; C 1 -C 8 alkyl group; phenyl group; phenyl group substituted with at least one substituent selected from the group consisting of halo, hydroxy, carboxy, carboalkoxy, nitro, cyano, amino, mercapto, thioalkyl, C 1 -C 8 alkyl, C 1 -C 8 cycloalkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy groups, and C 3 -C 8 heterocycloalkyl group comprising at least one heteroatom selected from O, S, and N; benzyl group; benzyl group substituted with at least one substituent selected from the group consisting of halo, hydroxy, carboxyl, carboalkoxy, nitro, cyano, amino, mercapto, thioalkyl, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy groups, and 5-7 membered heterocycloalkyl groups comprising at least one heteroatom selected from O, S and N; phenethyl group; or heteroaryl group comprising at least one heteroatom selected from O, S and N, wherein the heteroaryl group is selected from furyl, pyridyl, pyrimidyl, and piperonyl groups; and R 3 represents a hydrogen atom; C 1 -C 8 alkyl group; heteroaryl group comprising at least one heteroatom selected from O, S and N, wherein the heteroaryl group is selected from furyl, pyridyl, pyrimidyl, and piperonyl groups; phenyl group; phenyl group substituted with at least one substituent selected from the group consisting of halo, hydroxy, carboxy, carboalkoxy, nitro, cyano, amino, mercapto, thioalkyl, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 cycloalkyl, C 1 -C 8 alkoxy groups, and C 3 -C 8 heterocycloalkyl group comprising at least one heteroatom selected from O, S, and N; benzyl group; benzyl group substituted with at least one substituent selected from the group consisting of halo, hydroxy, carboxy, carboalkoxy, nitro, cyano, amino, mercapto, aryl, haloaryl, thioalkyl, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, C 1 -C 8 haloalkyl, arylcarbonyl, phenyl, and benzyl groups, and 5-7 membered heterocycloalkyl groups comprising at least one heteroatom selected from O, S and N, wherein the aryl can be substituted with at least one substituent selected from the group consisting of halo, alkyl, alkoxy, and phenoxy groups; or R 3 represents a benzoyl group; or furanoyl group.