Patent ID: 7202258

Claim:
A compound represented by the formula: or a pharmaceutically acceptable salt thereof, wherein: R represents 2-quinolinylcarbonyl; R′ represents hydrogen and radicals as defined for R 3 or R″SO 2 — wherein R″ represents radicals as defined for R 3 ; R 1 represents hydrogen, —CH 2 SO 2 NH 2 , —CH 2 CO 2 CH 3 , —CO 2 CH 3 , —CONH 2 , —CH 2 C(O)NHCH 3 , —C(CH 3 ) 2 (SH), —C(CH 3 ) 2 (SCH 3 ), —C(CH 3 ) 2 (S[O]CH 3 ), —C(CH 3 ) 2 (S[O] 2 CH 3 ), alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO 2 ) thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-alkyl serine, aspartic acid, beta-cyano alanine and valine side chains; R 1″ and R 1″ independently represent hydrogen and radicals as defined for R 1 , or one of R 1″ and R 1″ , together with R 1 and the carbon atoms to which R 1 , R 1″ and R 1″ are attached, represent a cycloalkyl radical; R 2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, —NO 2 , —C≡N, CF 3 , —OR 9 , —SR 9 , wherein R 9 represents hydrogen and alkyl radicals; R 3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl radicals, and thioalkyl, alkylthioalkyl and arythioalkyl radicals and the sulfone or sulfoxide thereof; R 4 and R 5 independently represent hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, and cycloalkylalkyl radicals, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide thereof; R 6 represents hydrogen and alkyl radicals; x represents 1 or 2; t represents either 0, 1 or 2; and Y represents O.