Patent ID: 7089934

Claim:
A drug delivery system for gastrointestinal deposition, comprising a multiple unit dosing device comprising a housing and an actuator, said device containing multiple doses of multiparticulates comprising drug particles, said device upon actuation delivering a unit dose of said multiparticulates, said drug particles having a mean diameter of greater than 10 μm to about 1 mm such that an effective dose of said drug cannot be delivered into the lower lung of a human patient, wherein said device comprises a drum having an inner cavity disposed therein for containing said multiparticulates, said drum having an outer lining, a rotatable inner lining disposed immediately within the outer lining and a stationary retaining strip located immediately within a portion of said inner lining; said outer lining having a dispensing hole at a point behind the retaining strip to dispense said unit dose; said rotating inner lining having a filling hole disposed therein and having a first position where said filling hole is not adjacent to said retaining strip to allow a unit dose of said multiparticulates to be filled therein; said rotating inner lining having a second position where said filling hole is adjacent to said retaining strip and in communication with said outer hole, wherein said unit dose is delivered from the reservoir to said dispensing hole when the inner lining is moved from said first position to said second position upon actuation and the unit dose is expelled from the device.