Patent ID: 7879835

Claim:
A method of treating osteoporosis, comprising administering a compound of formula (1) or its pharmacologically acceptable salt to a subject in need of such treatment: wherein, A is O, S, CH 2 , O—N═CH, or O—N═C(CH 3 ); X is H or halogen; Y is N or CH; Z is O or NH; R 1 is H or C 1-4 alkyl; R 2 is unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl, wherein, when the aryl is substituted, the substituent is at least one substituent selected from the group consisting of halogen, cyano, nitro, C 1-4 haloalkyl, C 2-4 haloalkenyl, hydroxy, C 1-8 alkyl, C 1-8 alkoxy, C 1-4 alkoxy C 1-4 alkoxy, C 1-4 dialkoxy C 1-4 alkyl, 1,3-dioxolan-2-yl, 1,3-dioxan-2-yl, C 2-8 alkenyloxy, C 2-4 alkynyloxy, C 3-6 cycloalkyl C 1-4 alkoxy, hydroxy C 1-4 alkyl, C 1-4 acyloxy, C 1-4 alkylcarbonyl, C 3-6 cycloalkylcarbonyloxy, C 1-4 alkoxycarbonyl, C 1-4 dialkylamino C 1-4 alkoxy, at least one N- or O-containing C 2-5 heterocyclo C 1-4 alkoxy, 2-morpholinoethoxy, dicyano C 2-4 alkenyl, cyano C 1-4 alkyloxy, acyl C 2-4 alkenyl, C 3-6 cycloalkyloxy, phenylcarbonyloxy, trifluoroacetyl, formyl, tetrahydropyranyloxy, C 1-4 alkoxycarbonyl C 1-4 alkoxy, C 1-4 alkylcarbonyl C 1-4 alkyl, C 1-4 alkoxycarbonyl C 1-4 alkyl, C 1-4 alkylcarbonyl C 2-4 alkenyl, C 1-4 alkylcarbonylhydroxy C 1-4 alkyl, C 1-4 alkylcarbonylhalo C 1-4 alkyl, hydroxyhalo C 1-4 alkyl, pyrazolyl, pyrrolidonyl, benzopyrazolyl, imidazolidonyl, benzoxazolyl, tetrazolyl, substituted amino, substituted amino C 1-2 alkyl, in which the substituted amino or substituted amino C 1-2 alkyl is represented by-(CH 2 ) n -NR 3 R 4 , in which n is 0, 1 or 2, R 3 and R 4 are each independently H, C 1-8 alkyl, C 1-8 haloalkyl, C 2-8 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl C 1-4 alkyl, C 1-4 alkoxy C 1-4 alkyl, C 3-8 cycloalkoxy C 1-4 alkyl, at least one N, O or S-containing C 2-7 heterocyclic C 1-4 alkyl, or an aryl, or R 3 and R 4 are fused together with the nitrogen atom to which they are attached to form a heterocyclic ring; and wherein the heteroaryl is an N-containing heteroaryl or chromone, wherein the substituted N-containing heteroaryl has at least one substituent selected from the group consisting of amino, halogen, C 1-6 haloalkyl, C 1-8 alkyl, C 1-8 alkoxy, phenyl, piperidinyl, morpholinyl, pyrrolidinyl, N-C 1-4 alkylanilinyl, N-methylpiperazinyl, C 1-4 alkylcarbonyl C 1-4 alkylthio, and C 1-4 dialkylaminocarbonylthio; and wherein the substituted chromone has a phenyl substituent which is unsubstituted or substituted with halogen or C 1-4 alkoxy.