Patent ID: 7833713

Claim:
A method of suppressing non-specific cross-hybridization between repetitive sequences present in nucleic acid probes and homologous repetitive sequences in target genomic nucleic acid, said method comprising the steps of: identifying repetitive sequences in a representative genomic region; synthesizing suppressive nucleic acid derived from said identified repetitive sequences, said suppressive nucleic acid substantially comprising said identified repetitive sequences and being substantially devoid of low copy sequences; and reacting said suppressive nucleic acid with a target nucleic acid thereby causing repetitive sequences in said suppressive nucleic acid to hybridize to homologous repetitive sequences in said target nucleic acid, whereby said repetitive sequences in said target nucleic acid are substantially blocked from hybridization with homologous repetitive sequences in a subsequently reacted nucleic acid probe, thereby suppressing non-specific cross-hybridization between said repetitive sequences in said probe and homologous repetitive sequences in said target nucleic acid.