Patent ID: 8546406

Claim:
A compound of the formula I in which denotes pyrrolidinyl, imidazolinyl, pyrazolyl, 2-oxa-5-aza-bicyclo [2.2.1]hept-5-yl, morpholinyl or N, Z denotes imidazopyrimidinyl, triazolopyrimidinyl or pyrrolo-pyrimidinyl, where Z is bonded to a nitrogen of the radical D, Y denotes (CH 2 ) n or is absent, X denotes O(CH 2 ) r , NH, NA, OC(═O), NHSO 2 or is absent, R 1 denotes H, A or COA, R denotes Het, Het denotes quinolinyl, isoquinolinyl or isoindolyl, each of which is mono-, di- or trisubstituted by Hal, A, (CH 2 ) m OR 6 , (CH2) m N(R 6 ) 2 , (CH 2 ) m CN, (CH 2 ) m COOR 6 , CONH(CH 2 ) m COOH, CONH(CH 2 ) m Het 2 , CO(CH 2 ) m N(R 6 ) 2 , CO(CH 2 ) m NH(CH 2 ) r COOA, (CH 2 ) r CONH(CH 2 ) m Ar 1 , COCH[(CH 2 ) m CONH 2 ]NH 2 , COCH[(CH 2 ) m CONH 2 ]NHCOOA, COCH[(CH 2 ) m Het 2 ]NHCOOA, COCH(NHCOA)CH 2 CONH 2 , (CH 2 ) m NHCOOA, COCH[(CH 2 ) m CN]NHCOOA, COO(CH 2 ) m CN, COO(CH 2 ) m N(R 6 ) 2 , CO(CH 2 ) m CON(R 6 ) 2 , COR 6 , COHet 2 , O(CH 2 ) m Ar 1 and/or ═O, Het 2 denotes imidazolyl, indolyl, isoxazolyl, pyridazinyl, pyrazolyl, benzimidazolyl, pyridyl, dibenzofuranyl, carbazolyl, benzo-furanyl, isoindolyl, quinazolinyl, quinoxalinyl, pyrimidinyl, indazolyl, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, triazolyl, tetrazolyl, thiadiazole, benzothiazolyl, imidazo[1,2-α]pyridinyl or 1,3-benzodioxolyl, R 6 denotes H or alkyl having 1-6 C atoms, Ar 1 denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal and/or SO 2 NH 2 , A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by F, Cl, Br and/or OH, or cyclic alkyl having 3-7 C atoms, Hal denotes F, Cl, Br or I, m denotes 0, 1 , 2, 3, 4, 5 or 6, n denotes 1 or 2, r denotes 0, 1 or 2, and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.