Patent ID: 7332498

Claim:
A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts, where: W, X, Y and Z are independently —N═ or —C═, provided that at least one but no more than two of W, X, Y and Z are —N═; R 1 , R 2 , R 3 and R 4 are independently chosen from hydrogen, lower alkyl, substituted lower alkyl, methoxy, halogen and cyano, provided that R 1 , R 2 , R 3 or R 4 is absent where W, X, Y or Z, respectively, is —N═ R 5 is optionally substituted aralkyl; R 6 is lower alkyl; R 6′ is hydrogen; R 7 is a primary-amino-substituted lower alkyl, secondary-amino-substituted lower alkyl or tertiary-amino-substituted lower alkyl alkyl or; and R 8 is —C(O)—R 9 , in which: R 9 is selected from lower alkyl-, lower alkoxy-, and/or halo-substituted phenyl; or a pharmaceutically acceptable salt thereof.