Patent ID: 8906929

Claim:
A compound of Formula I where: R 1 is hydrogen, alkyl, or cycloalkyl; R 2 is hydrogen or alkyl; R 3 is hydrogen, alkyl or halo; R 4 is cycloalkyl or Ar 3 ; or R 4 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 alkyl substituents; R 5 is hydrogen or alkyl; Ar 1 is phenyl substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; Ar 2 is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, or trizainyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, and CON(R 5 ) 2 ; Ar 3 is phenyl, chromanyl, or dihydrobenzoxazinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; X 1 is CH, CH 2 , O, S, or NR 5 ; X 2 is alkylene or alkenylene; and X 3 is CH, CH 2 , CH 2 O, O, S, or NR 5 ; or a pharmaceutically acceptable salt thereof.