Patent ID: 8455522

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is C 1-7 alykl, C 6-10 aryl-C 1-7 alkyl, hydroxy-C 1-7 alkyl, or C 3-8 cycloalkyl; R 2 and R 4 are each independently hydrogen or halogen; R 3 is hydrogen or C 1-7 alkoxy; R 5 is hydrogen, halogen, C 1-7 alkoxy, C 1-7 alkyl, C 3-8 cycloalkyl, cyano, —CH 2 NR 8 R 9 , —CH 2 NR 8 (SO 2 )—C 1-7 alkyl, —CH 2 NR 8 (SO 2 )—C 3-8 cycloakyl, —NR 8 (SO 2 )—C 1-7 alkyl, —NR 8 (SO 2 )—C 3-8 cycloalkyl or —NHC(O)NR 8 R 9 ; in which each alkyl and cycloalkyl is optionally substituted with one or more substitutents selected from the group consisting of C 1-7 alkoxy, halogen, hydroxy, —NH 2 , —NH(C 1-7 alkyl) and —N(C 1-7 alkyl) 2 ; R 6 is hydrogen, C 1-7 alkyl, C 3-8 cycloalkyl, heterocyclyl, —C(O)—C 1-7 alkyl, —C(O)NR 8 R 9 , —C 1-7 alkyl-NR 8 C(O)—C 1-7 alkyl, —CH 2 NR 8 (SO 2 )—C 1-7 alkyl, —C 1-7 alkyl-NR 8 —S(O) n —C 1-7 alkyl, —CH 2 NR 8 —S(O) n —C 3-8 cycloalkyl or —CH 2 NR 8 (SO 2 )—C 1-7 alkyl; in which each alkyl and cycloalkyl is optionally substituted with one or more substitutents selected from the group consisting of C 6-10 aryl, C 1-7 alkoxy, halogen, hydroxy and —NH 2 , —NH(C 1-7 alkyl) and —N(C 1-7 alkyl) 2 ; and R 8 and R 9 are each independently hydrogen, C 1-7 alkyl or C 6-10 aryl-C 1-7 alkyl; and n is 1 or 2; wherein each heteroaryl is a mono- or bicyclic aromatic moiety comprising 5-10 ring atoms selected from carbon atoms and 1 to 5 heteroatoms, and each heterocyclyl is a mono- or bicyclic saturated or partially saturated but non-aromatic moiety comprising 4-10 ring atoms selected from carbon atoms and 1 to 5 heteroatoms; and each heteratoms being O, N or S.