Patent ID: 8762067

Claim:
A computer-implemented method, comprising: administering with a predetermined velocity a plurality of frozen particle compositions, including at least two subsets including different therapeutic or reinforcement agents and at least one tracer agent, to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue; comparing, using one or more microprocessors, information regarding at least one aspect of cellular or tissue abrasion or ablation of the at least one biological tissue of at least one subject, and information regarding at least one clinical outcome following receipt by the at least one subject of the plurality of frozen particle compositions; measuring a signal from the at least one tracer agent; communicating real-time feedback control of the amount of a frozen particle composition delivered to the at least one subject based on the measurement of the signal from the at least one tracer agent; and providing output information, including at least one of a response signal, a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered; a code indicative of at least one therapeutic agent delivered; a code indicative of at least one diagnostic agent delivered; a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject; a code indicative of at least one dispersion or location of at least one delivered agent; a code indicative of at least one detection material delivered; a code indicative of the depth of penetration of a delivered agent; or a code indicative of the condition of at least one location of an administered frozen particle composition.