Patent ID: 7364911

Claim:
A method for labeling a sample molecule, comprising: (a) contacting a sample molecule with a composition comprising a solid support coupled to a chemical group comprising a cleavable functional group, a tag and a reactive group, wherein said cleavable functional group is covalently coupled to said solid support, said tag is covalently coupled to said cleavable functional group, and said reactive group is covalently coupled to said tag and wherein said cleavable functional group, said tag and said reactive group are positioned relative to each other to allow transfer of said tag to said sample molecule and release of said sample molecule from said solid support upon cleavage of said cleavable functional group, under conditions allowing said sample molecule to covalently bind to said reactive group, thereby covalently linking said sample molecule to said solid support; and (b) cleaving said cleavable functional group, thereby transferring said tag to said sample molecule and releasing said tagged sample molecule from said solid support, thereby labeling said sample molecule with said tag.