Patent ID: 7071224

Claim:
A compound of formula I: wherein: each R 1 and R 2 are independently selected from (1–4C)alkyl, (2–4C)alkenyl, (2–4C)alkynyl, (3–6C)cycloalkyl, cyano, halo, —OR a , —SR a , —NR a R b , —S(O)R c and —S(O) 2 R c ; where each R a and R b independently represents hydrogen, (1–4C)alkyl, (2–4C)alkenyl, (2–4C)alkynyl or (3–6C)cycloalkyl; each R c independently represents (1–4C)alkyl,(2–4C)alkenyl, (2–4C)alkynyl or (3–6C)cycloalkyl; or two adjacent R 1 groups or two adjacent R 2 groups are joined together to form (3–6C)alkylene, (2–4C)alkylene-O— or —O-(2–4C)alkylene-O—; a and b each independently are 0 or an integer of from 1 to 5; each R 3 independently is fluoro or (1–4C)alkyl; c is 0 or an integer of from 1 to 3; R 4a and R 4b are independently selected from hydrogen, (1–4C)alkyl, and phenyl-(1–4C)alkyl; or R 4a and R 4b together with the nitrogen atom to which they are attached form a (3–6C)heterocyclic ring optionally containing one additional heteroatom selected from nitrogen, oxygen or sulfur and wherein the heterocyclic ring is unsubstituted or substituted with 1 or 2 substituents selected independently from (1–4C)alkyl and fluoro; e is 1 or2; m is 4, 5 or 6; R 5 is selected from hydrogen, (1–4C)alkyl, and (3–4C)cycloalkyl; R 6 is hydrogen or an unbranched (1–4C)alkyl; or R 6 and R 8 are joined, together with the atoms to which they are attached, to form a pyrrolidin-2-yl group; R 7 is selected from hydrogen, (1–6C)alkyl, (3–6C)cycloalkyl, —CH 2 Ar 1 , —CH 2 CH 2 ——CH 2 CH 2 —O-(1–4C)alkyl; wherein Ar 1 represents phenyl or (3–5C)heteroaryl, wherein the phenyl or heteroaryl group is unsubstituted or substituted with from 1 to 3 substituents selected independently from halo, (1–4C)alkyl and (1–4C)alkoxy; wherein each alkyl and alkoxy is optionally substituted with from 1 to 3 fluoro substituents; and R 8 is hydrogen or (1–6C)alkyl; or R 7 and R 8 together with the nitrogen atom to which they are attached form a pyrrolidin-1-yl, piperidin-1-yl, morpholin-1-yl or thiomorpholin-1-yl group; wherein each alkyl group in R 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 6 , R 7 , R 8 and R a-c is optionally substituted with from 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or solvate or stereoisomer thereof.