Patent ID: 8865644

Claim:
A rapamycin formulation comprising rapamycin and a recombinant high-density lipoprotein; wherein the rapamycin is present in an amount of 0.1 to 10 parts by weight based on a total 100 parts by weight of the recombinant high-density lipoprotein comprising an apolipoprotein (apoA-I) mutant V156K; the recombinant high-density lipoprotein comprises a mole ratio of 90 to 100 of the apoA-I mutant V156K, 1 to 10 of phospholipid, 0.1 to 2.0 of cholesterol, and 120 to 180 of sodium cholate; wherein the apoA-I mutant V156K is prepared by substitution of the amino acid valine at residue 156 with the amino acid lysine.