Patent ID: 7125986

Claim:
A compound of formula (I): wherein R 1 and R 2 are each independently hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, —COOR a , —CONR b R c , cyano, —C(═O)R d , —OR e , aryl, heteroaryl, oxazolidinyl, isoxazolidinyl, morpholinyl, —S(O) m R f , —NR g R h , azido, or halo; wherein R 3 is acetoxymethyl, chloroacetoxymethyl, phenylacetoxymethyl, (3,4-dihydroxyphenyl)acetoxymethyl, or (1-methyl-1H-tetrazol-5-ylthio)acetoxymethyl; R 4 is hydrogen (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, aryl, or heteroaryl; m and n are each independently 0, 1, or 2; each R a –R f is independently hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, aryl, heteroaryl, oxazolidinyl, isoxazolidinyl, or morpholinyl; each R g or R h is independently hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, (C 1 –C 10 )alkanoyl, aryl, benzyl, phenethyl, heteroaryl oxazolidinyl, isoxazolidinyl, or morpholinyl; or R g and R h together with the nitrogen to which they are attached are triazolyl, imidazolyl, oxazolidinyl, isoxazolidinyl, pyrrolyl, morpholino, piperidino, pyrrolidino, pyrazolyl, indolyl, or tetrazolyl; wherein any (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 2 –C 10 )alkenyl, (C 2 –C 10 )alkynyl, (C 1 –C 10 )alkanoyl, benzyl, heteroaryl, arylcarbonyl, heteroarylcarbonyl, oxazolidinyl, isoxazolidinyl, or morpholinyl of R 1 –R 4 , or R a –R h , may optionally be substituted with 1, 2, or 3 Z; and each Z is independently halo, nitro, cyano, hydroxy, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 1 –C 10 )alkoxy, (C 1 –C 10 )alkanoyl, (C 2 –C 10 )alkanoyloxy, trifluoromethyl, aryl, aryloxy, heteroaryl, or —SR n , wherein R n is hydrogen, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, aryl, benzyl, phenethyl, or heteroaryl; and further wherein any aryl, aryloxy, heteroaryl, benzyl, or phenethyl of Z may optionally be substituted with 1, 2, or 3 substituents selected from the group consisting of halo, nitro, cyano, hydroxy, (C 1 –C 10 )alkyl, (C 3 –C 8 )cycloalkyl, (C 1 –C 10 )alkoxy, (C 1 –C 10 )alkanoyl, (C 2 –C 10 )alkanoyloxy, benzyloxy, 4–methoxybenzyloxy, and trifluoromethyl; or a pharmaceutically acceptable salt thereof.