Patent ID: 6995142

Claim:
A compound of the formula I: wherein: Y is —N(R y )—, or —O—, where R y is independently H or lower alkyl; R 1 is H, F, an alkyl group, OH, SH, or an O-alkyl group; R 2 and R 3 are each independently H; where n is an integer from 0 to 5, A 1 is CH or N, A 2 and each A 3 are independently selected from C(R 41 )(R 41 ), N(R 41 ), S, S(O), S(O) 2 , and O, and A 4 is NH or NR 41 , where each R 41 is independently H or lower alkyl, provided that no more than 2 heteroatoms occur consecutively in the ring formed by A 1 , A 2 , (A 3 ) n , A 4 and C═O; and provided that at least one of R 2 and R 3 is R 5 and R 6 are each independently H, F, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a substituted or unsubstituted benzyl group or a heteroaryl group; R 7 and R 8 are each independently H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, a benzyl group, a naphthylmethyl group, an aryl group, a heteroaryl group, —OR 17 , —SR 17 , —NR 17 R 18 , —NR 19 NR 17 R 18 , or —NR 17 OR 18 , where R 17 , R 18 , and R 19 are each independently H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, or an acyl group; R 9 is a five-membered heterocycle having from one to three heteroatoms selected from O, N, and S, or R 9 is where R 2 is and Z and Z 1 are each independently H, F, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, —C(O)R 21 , —CO 2 R 21 , —CN, —C(O)NR 21 , R 22 , —C(O)NR 21 OR 22 , —C(S)R 21 , —C(S)NR 21 R 22 , —NO 2 , —SOR 21 , —SO 2 R 21 , —SO 2 NR 21 R 22 , —SO(NR 21 )(OR 22 ), —SONR 21 , —SO 3 R 21 , —PO(OR 21 ) 2 , —PO(R 21 )(R 22 ), —PO(NR 21 R 22 )(OR 23 ), PO(NR 21 R 22 )(NR 23 R 24 ), —C(O)NR 21 NR 22 R 23 , or —C(S)NR 21 NR 22 R 23 , where R 21 , R 22 , R 23 , and R 24 are each independently H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an acyl group, or a thioacyl group, or any two of R 21 , R 22 , R 23 , and R 24 , together with the atom(s) to which they are bonded, form a heterocycloalkyl group, provided that Z and Z 1 are not both H; or Z 1 and R 1 , together with the atoms to which they are bonded, form a cycloalkyl or heterocycloalkyl group; or Z and Z 1 , together with the atoms to which they are bonded, form a cycloalkyl or heterocycloalkyl group; or a solvate thereof.