Patent ID: 8455498

Claim:
A compound of formula (I), an N-oxide form, a pharmaceutically acceptable addition salt or a stereo-chemically isomeric form thereof, wherein n is 0, 1, 2 or 3 and when n is 0 then a direct bond is intended; Q is X is Y is Z is nitrogen; R 1 is —C(O)NR 5 R 6 , —C(O)—C 1-6 alkanediylSR 7 , —NR 8 C(O)N(OH)R 7 , —NR 8 C(O)C 1-6 alkanediylSR 7 , or —NR 8 C(O)C═N(OH)R 7 wherein R 5 and R 6 are each independently hydrogen, hydroxy, C 1-6 alkyl, hydroxyC 1-6 alkyl, aminoC 1-6 alkyl or aminoaryl; R 7 is hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, arylC 1-6 alkyl, C 1-6 alkylpyrazinyl, pyridinone, pyrrolidinone or methylimidazolyl; R 8 is hydrogen or C 1-6 alkyl; R 2 is hydrogen, halo, hydroxy, amino, nitro, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, di(C 1-6 alkyl)amino, hydroxyamino or naphtalenylsulfonylpyrazinyl; R 3 is arylC 2-6 alkenediyl, furanylcarbonyl, naphthalenylcarbonyl, C 1-6 alkylaminocarbonyl, aminosulfonyl, di(C 1-6 alkyl)aminosulfonylaminoC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-12 alkylsulfonyl, di(C 1-6 alkyl)aminosulfonyl, trihaloC 1-6 alkylsulfonyl, di(aryl)C 1-6 alkylcarbonyl, thiophenylC 1-6 alkylcarbonyl, pyridinylcarbonyl or arylC 1-6 alkylcarbonyl; R 4 is hydrogen, hydroxy, amino, hydroxyC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkyloxy, arylC 1-6 alkyl, aminocarbonyl, hydroxycarbonyl, aminoC 1-6 alkyl, aminocarbonylC 1-6 alkyl, hydroxycarbonylC 1-6 alkyl, hydroxyaminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylaminoC 1-6 alkyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; aryl in the above is phenyl, or phenyl substituted with one or more substituents each that are each independently halo, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, cyano or hydroxycarbonyl.