Patent ID: 7820144

Claim:
A compound of formula I, including a physiologically acceptable salt, diasteromer, enantiomer or double bond isomer of formula I: wherein: Z is selected from hydrogen, halogen, hydroxy, alkoxy, thioalkoxy, aryl or alkyl; Alk is selected from an alkyl group or a substituted alkyl group; X is selected from NHSO 2 R 5 , a 5, 6 or 7 member heterocyclic ring, a substituted 5, 6 or 7 member heterocyclic ring, a bicyclic ring or a heterobicyclic ring; R 5 is selected from alkyl, halogenated alkyl and fluorinated alkyl; R is selected from hydrogen, CN, CHO, alkyl, halogenated alkyl, fluorinated alkyl or substituted alkyl; Y is selected from C═O, CH═CH (cis or trans), CONH or C═NH; and A is selected from alkyl, COCF 3 , adamantyl, azoadamantyl, cycloalkyl, phenyl, naphthyl, 9-anthracenyl, pyridinyl, quinolinyl, isoquinolinyl, quinazolinyl, an aliphatic bicyclic ring, an azabicyclic ring, a heterobicyclic ring, any of the above with one or more substituents independently selected from amino, halogen, hydroxy, nitro, nitroso, azido, isothiocyanato, cyano, COOH, alkyl, CONR 3 R 4 (where R 3 and R 4 are each independently selected from H, alkyl or substituted alkyl), NCOR 3 R 4 (where R 3 and R 4 are each independently selected from H, alkyl, substituted alkyl, CF 3 ), SO 2 NR 3 R 4 (where R 3 and R 4 are each independently selected from H, alkyl, substituted alkyl or CF 3 ); or a salt of any of the above; wherein at least one atom in the compound is an unnatural isotope.