Patent ID: 8344153

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: Ar is a phenyl ring or a 5-10 membered monocyclic or fused bicyclic heteroaryl ring having up to 2 atoms selected from nitrogen, wherein each ring is optionally substituted with up to 3 substituents independently selected from fluoro, chloro, C 1-4 aliphatic, C 3-4 cycloaliphatic, —OC 1-4 aliphatic, —OC 3-4 cycloaliphatic, —N(J R1 )C(O)C 1-4 aliphatic, or N(J R1 ) 2 , wherein each of said aliphatic or cycloaliphatic is optionally substituted with up to 3 occurrences of fluoro; R 1 is selected from —C(O)R 1a , —C(O)OR 1a , or —C(O)N(R 1a )(R 1b ) wherein R 1a is C 1-4 aliphatic, C 3-6 cycloaliphatic, or C 5-10 heterocyclic having up to 2 atoms selected from oxygen, sulfur, or nitrogen, wherein R 1a is optionally substituted with 1, 2, 3, or 4, occurrences of J R ; each J R is independently fluoro, oxo, —C(O)J R1 , —C(O)N(J R1 ) 2 , —C(O)O(J R1 ), —N(J R1 )C(O)J R1 , —OJ R1 , —SJ R1 , —S(O)J R1 , phenyl or a 5-10 membered heteroaryl or heterocyclyl ring having up to 2 atoms selected from nitrogen, oxygen, or sulfur, wherein said phenyl, heteroaryl, or heterocyclyl is optionally substituted with 1 or 2 J R2 groups; R 1b is, independently, hydrogen, C 1-4 aliphatic, C 3-6 cycloaliphatic; or R 1a and R 1b , together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring, wherein said heterocyclic ring optionally comprises one additional heteroatom selected from nitrogen and oxygen, and wherein said heterocyclic ring is optionally substituted with 1 or 2 J R2 groups; R 2 is C 1-4 aliphatic optionally substituted with 1, 2, or 3 J R2 groups; each J R1 is independently selected from hydrogen, C 1-4 aliphatic, C 3-6 cycloaliphatic, phenyl, benzyl, or 5-6 membered heteroaryl ring having up to two atom selected from nitrogen, oxygen, or sulfur, wherein each of said C 1-4 aliphatic, phenyl, benzyl, or heteroaryl is optionally substituted with up to three J R2 groups; and each J R2 is, independently, selected from chloro, fluoro, —CN, —NO 2 , oxo, C 1-4 alkyl, C 3-6 cycloalkyl, —OH, —OC 1-4 alkyl, —OPhenyl, or —OCH 2 Phenyl, wherein each of said alkyl, cycloalkyl or phenyl is optionally substituted with up to 3 fluoro groups.