Patent ID: RE39920

Claim:
A method of monitoring transplanted material rejection or acceptance of cells, tissue or organs that are transplanted in areas other than the urinary tract in a patient, comprising: a) providing a urine sample s from a patient suspected of containing cell- free, transrenal nucleic acid s of the transplanted material, which transplanted material is located outside of the urinary tract from the cells, tissue or organs that are transplanted in areas other than the urinary tract in the patient ; and b) quantitatively analyzing said urine sample for nucleic acids from the cell genome of the transplanted material that are different from nucleic acids of the recipient and that have crossed the kidney barrier for one or more specific sequences of the cell- free, transrenal nucleic acids from dying cells in the transplanted cells, tissues or organs that are different from sequences of nucleic acids of the patient wherein said analyzing comprises the step of detecting said one or more specific sequences of nucleic acids from the transplanted cells, tissues or organs in the nucleic acids that are no more than 1000 nucleotides in length from urine samples and have crossed the kidney barrier to monitor rejection or acceptance of the transplanted cells, tissues or organs .