Patent ID: 7396645

Claim:
A method for testing the propensity of a test compound to induce cholestasis in a test subject, the method comprising: a) administering an effective amount of the test compound to the test subject for a selected period of time; b) determining the change in expression level of each of a plurality of cholestasis indicator genes, wherein said plurality of indicator genes comprises the genes with GenBank accession numbers: AB010467 (SEQ ID NO: 1), X13295 (SEQ ID NO: 5), BF284899 (SEQ ID NO: 3), BF395678 (SEQ ID NO: 4), and AI411194 (SEQ ID NO: 2); c) determining the statistical significance of the change in expression level of each of said cholestasis indicator genes; d) assigning a probability of cholestasis induction due to said test compound if said plurality of said indicator genes exhibit a statistically significant change in expression level.