Patent ID: 8440787

Claim:
A polymer having the structure: wherein: A is —(X 3 ) d -(L 3 ) e -(X 4 ) f -POLY 2 -Z 2 or —(X 3 ) d -(L 3 ) e -(X 4 ) f —Z 2 each POLY 1 and POLY 2 , which may be the same or different, is a water-soluble, non-peptidic polymer; each X 1 , X 2 , X 3 , and X 4 , which may be the same or different, is a spacer moiety; each L 1 , L 2 , and L 3 , which may be the same or different, are linkages; each Z 1 is selected from a multiarm structure selected from the group consisting of wherein each m is 1-350, Me is methyl, and each Z is a hydroxyapatite-targeting moiety with the proviso that at least one Z 1 is a hydroxyapatite-targeting moiety; Z 2 is a functional group, optionally attached to POLY 2 through a spacer moiety; each a, b, c, d, e, and f, which may be the same or different, is either zero or one; R is a monomeric or oligomeric multiarm core molecule derived from a molecule comprising at least p+1 sites available for attachment; and p is an integer in the range of 2-32.