Patent ID: 7091345

Claim:
A compound of formula I wherein R 1 represents hydrogen or alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, each of which may be optionally substituted with halogen, hydroxy, cyano, nitro, amino, acylamino, alkyl, alkoxy, alkoxyalkyl, —CONH 2 , —SO 2 NH 2 , —S(O) m -alkyl, —NH-alkyl, —N(alkyl) 2 , —CONH(alkyl), CON(alkyl) 2 , —SO 2 NH(alkyl), —SO 2 N(alkyl) 2 ; R 2 represents halogen, cyano or CF 3 ; R 3 each R 3 is independently selected from halogen, hydroxy, cyano, nitro, amino, acylamino, —CONH 2 , —SO 2 NH 2 , —S(O) m -alkyl, —NH-alkyl, —N(alkyl) 2 , —CONH(alkyl), —CON(alkyl) 2 , —SO 2 NH(alkyl), —SO 2 N(alkyl) 2 , or alkyl, alkoxy or alkoxyalkyl, each of which may be optionally substituted with halogen, hydroxy, cyano, nitro, amino, acylamino, alkyl, alkoxy, alkoxyalkyl, —CONH 2 , —SO 2 NH 2 , —S(O) m -alkyl, —NH-alkyl, —N(alkyl) 2 , —CONH(alkyl), CON(alkyl) 2 , —SO 2 NH(alkyl), —SO 2 N(alkyl) 2 ; R 4 represents hydrogen, alkyl, alkoxy or cyano; A is selected from the group R 5 is hydrogen, halogen, hydroxy, cyano, amino, acylamino, alkyl, alkoxy, alkoxyalkyl, —CONH 2 , —SO 2 NH 2 , —S(O) m -alkyl, —NH-alkyl, —N(alkyl) 2 , —CONH(alkyl), —CON(alkyl) 2 , —SO 2 NH(alkyl) or —SO 2 N(alkyl) 2 ; R 6 , R 6 ′ are each independently selected from hydrogen, alkyl or oxo; R 7 is hydrogen, acyl, alkoxycarbonyl, alkoxyalkyl, alkyl or alkyl substituted with hydroxy, cyano, —S(O) m -alkyl, amino, —NH-alkyl or —N(alkyl) 2 ; R 8 , R 8 ′ are each independently selected from hydrogen, oxo, alkoxy, alkoxyalkyl, alkyl or alkyl substituted with hydrogen, hydroxy, cyano, pyrrolidin-1-yl, morpholino, piperazin-1-yl, 4-alkyl-piperazin-1-yl, piperidin-1-yl, —S(O) m -alkyl, or a group NR 9 R 9 ′, provided that when either R 8 or R 8 ′ represent an oxo group, this oxo group is not adjacent to an S(O) m group; R 9 and R 9 ′ are each independently selected from hydrogen, alkyl or cycloalkyl; X is oxygen or S(O) m ; the dashed line is an optional second chemical bond; n is 0, 1 or 2; m is 0, 1 or 2; and p is 0, 1 or 2; or a pharmaceutically acceptable salt or N-oxides thereof.