Patent ID: 7402597

Claim:
A pharmaceutical composition comprising a therapeutically effective amount of the compound of formula (I): or a salt thereof, wherein A is O, S or NR 7 in which R 7 is hydrogen or C 1-8 alkyl; B 1 is CW or N in which W is hydrogen or a bond; B 2 is O, S or NR 8 in which R 8 is hydrogen or C 1-8 alkyl; each of X 1 and X 2 is O, S, NH, NHC(═O), C(═O), C(═N—OR 9 ), CH(OR 10 ), —CH═CH—, C═C or a bond in which each of R 9 and R 10 is hydrogen or C 1-8 alkyl; Y is a C 1-8 alkylene chain, which is optionally substituted with C 1-8 alkyl or C 1-8 alkyl substituted with 1-3 halogens; Z is NH, O or S R 1 is aryl, which is optionally substituted with a group or atom selected from the group consisting of 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkyl substituted with 1-3 halogens, hydroxyl, nitro, amino, phenyl, pyridyl and halogen, or a heterocyclic group having five to eight membered ring comprising one to three hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur and the other atoms consisting of carbon, wherein a benzene ring is optionally condensed with the heterocyclic ring; R 2 is C 2-8 alkyl, C 1-8 alkyl substituted with 1-3 halogens, C 3-7 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-4 alkyl substituted with aryl, which is optionally substituted with a group or atom selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkyl substituted with 1-3 halogens, hydroxyl, nitro, amino, phenyl, pyridyl and halogen, or C 1-4 alkyl substituted with a heterocyclic group having a five to eight membered ring, comprising one to three hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur, and the other atoms are carbon; R 3 is halogen, trifluoromethyl, C 1-8 alkyl, C 2-8 alkenyl or C 2-8 alkynyl; each of R 4 and R 5 is independently hydrogen, C 1-8 alkyl or C 1-8 alkyl substituted with 1-3 halogens; and R 6 is hydrogen, C 1-8 alkyl substituted with amino, C 1-8 alkyl or alkali metal; provided that each of Z and R 3 is attached to the benzene ring, and X 2 is not attached to the benzene ring; and a pharmaceutically acceptable carrier.