Patent ID: 8058390

Claim:
A crystal consisting of HDM2 amino acid residues 17-111 of SEQ ID NO:1, with a ligand, wherein said ligand is a non-peptide small molecule inhibitor of HDM2, wherein said non-peptide small molecule inhibitor prevents HDM2 from interacting with p53, and wherein said crystal has a spacegroup selected from the group consisting of a trigonal spacegroup of P3 2 21 and a tetragonal spacegroup of P4 3 2 1 2 and said crystal comprises a unit cell selected from the group consisting of: a cell having dimensions of 98.6 â„«, 98.6 â„« and 74.7 â„«, and alpha=90Â°, beta=90Â° and gamma=120Â°; and, a cell having dimensions of 54.3 â„«, 54.3 â„«, 83.3 â„« and alpha=90Â°, beta=90Â° and gamma=90Â°.