Patent ID: 8828988

Claim:
A method of therapeutically treating a bacterial infection in a subject comprising administering to the subject an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is selected from hydrogen, C 1 -C 6 alkyl, phenyl and C 1 -C 6 alkoxy, wherein each C 1 -C 6 alkyl and C 1 -C 6 alkoxy represented by X is optionally substituted with halo, unsubstituted C 1 -C 6 alkyl, halo(C 1 -C 6 )alkyl, unsubstituted C 1 -C 6 alkoxy or halo(C 1 -C 6 )alkoxy; Y is selected from hydrogen, fluoro, chloro, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 ) alkylene-N(R 1 )(R 2 ) and phenyl, wherein each C 1 -C 6 alkyl, C 0 -C 6 alkylene and C 1 -C 6 alkoxy represented by Y is optionally substituted with halo, unsubstituted C 1 -C 6 alkyl, halo(C 1 -C 6 )alkyl, unsubstituted C 1 -C 6 alkoxy or halo(C 1 -C 6 )alkoxy; each of R 1 and R 2 is independently selected from hydrogen, and C 1 -C 6 alkyl; and Z is selected from hydrogen, halo, C 1 -C 6 alkyl, phenyl, —N(R 3 )(R 4 ), (C 1 -C 6 ) alkylene-N(R 5 )(R 6 ), wherein R 3 is selected from hydrogen, C 1 -C 6 alkyl, —(C 1 -C 6 alkylene)-phenyl, phenyl, —(C 1 -C 6 alkylene)-(C 3 -C 7 cycloalkyl), —(C 1 -C 6 alkylene)-O—(C 1 -C 6 alkyl), —(C 1 -C 6 alkylene)-N(R 5 )(R 6 ), —C(O)—(C 0 -C 6 alkylene)-N(R 5 )(R 6 ), —C(O)—(C 1 -C 6 alkyl), —C(O)H, —C(O)-phenyl, and —S(O) 2 —R 5 ; R 4 is selected from hydrogen, C 1 -C 6 alkyl; or R 3 and R 4 are taken together with the nitrogen atom to which they are bound to form a (4-7 membered) heterocyclic ring optionally containing one additional heteroatom selected from S, O or N; and R 5 is selected from hydrogen, C 1 -C 6 alkyl, and phenyl; R 6 is selected from hydrogen and C 1 -C 6 alkyl; or R 5 and R 6 are taken together with the nitrogen atom to which they are bound to form a (4-7 membered) heterocyclic ring optionally containing one additional heteroatom selected from S, O or N, wherein each (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylene or a (4-7 membered) heterocyclic ring in the group represented by Z is optionally substituted with fluoro, —OH, or —CH 3 ; and wherein each phenyl in the group represented by X, Y, Z, R 3 and R 5 is optionally substituted with halo, unsubstituted C 1 -C 6 alkyl, halo(C 1 -C 6 )alkyl, unsubstituted C 1 -C 6 alkoxy, halo(C 1 -C 6 )alkoxy, cyano or nitro, wherein Y and Z are not simultaneously hydrogen.