Patent ID: 8658825

Claim:
A method for preparing aminophosphine ligands comprising reacting a compound of the formula I with a metal phosphide reagent of the formula Y—PR 8 R 9 under conditions to provide, optionally after removal of a protecting group (PG), a compound of the formula II, wherein q is 0 or 1; where when q is 0, the N atom is further linked to any one of R 1 , R 2 , R 3 , R 4 , R 5 or R 6 ; n is 0, 1, 2, 3 or 4; Y is a cation; R 1 to R 6 are simultaneously or independently selected from H, C 2-20 alkenyl, C 2-20 alkynyl, C 3-20 cycloalkyl, aryl and heteroaryl, said latter 6 groups being optionally substituted, or two adjacent or geminal groups, including the nitrogen atom of the amino group, are linked together to form an optionally substituted monocyclic or polycyclic, metalated, saturated, unsaturated and/or aromatic ring system having 3 or more atoms; R 7 is selected from H, C 1-6 alkyl, aryl, and a suitable amine protecting group, said alkyl and aryl groups being optionally substituted; R 7′ is selected from H, C 1-6 alkyl, and aryl, said alkyl and aryl groups being optionally substituted; R 8 and R 9 are simultaneously or independently selected from H, C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, aryl, heteroaryl, OR 10 and N(R 10 ) 2 , said latter 7 groups being optionally substituted, or R 8 and R 9 are linked together to form an optionally substituted monocyclic or polycylic, saturated, unsaturated and/or aromatic ring system having 4 or more atoms, including the phosphorous atom to which said R 8 and R 9 groups are linked, and in which one or more carbon atoms in said monocyclic or polycyclic ring system are optionally replaced with a heteromoiety selected from O, S, N, NH and NC 1-6 alkyl; R 10 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl and aryl, said latter 4 groups being optionally fluoro-substituted; the optional substituents are selected from one or more of halo, OH, NH 2 , OR 11 , N(R 11 ) 2 and R 11 , and R 11 is selected elected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl and aryl, said latter 4 groups being optionally fluoro-substituted.