Patent ID: 8540990

Claim:
A method for reducing stiffness in an individual having osteoarthritis comprising administering an effective amount of a monoclonal anti-NGF antagonist antibody to the individual, wherein the anti-NGF antagonist antibody blocks the interaction of human NGF with p75 and trkA, wherein the anti-NGF antagonist antibody: (a) binds NGF with a K D of less than about 2 nM; (b) inhibits human NGF-dependent survival of mouse E13.5 trigeminal neurons with an IC50 of about 100 pM or less, wherein the IC50 is measured in the presence of about 15 pM human NGF; and (c) inhibits human NGF-dependent survival of mouse E 13.5 trigeminal neurons with an IC50 of about 10 pM or less, wherein the IC50 is measured in the presence of about 1.5 pM of NGF.