Patent ID: 7880007

Claim:
A compound of formula Ib: or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, halo, cyano, hydroxy, —OCF 3 , —COOH, —C(O)O-alkyl, or —O-alkyl; R 2 is a 5-12 membered bicycloalkyl or 5-12 membered bicycloalkenyl, which is optionally substituted with 1-3 of R 6 ; Each R 6 is independently —Z B R 7 , wherein each Z B is independently a bond; Each R 7 is independently R B , halo, —OH, —NH 2 , —NO 2 , —CN, or —OCF 3 ; Each R B is independently hydrogen; R 3 is a C 1-8 alkyl or alkenyl, which is optionally substituted with 1-3 of halo, hydroxy, cyano, alkylcarbonyl, alkoxy, phenyl, or combinations thereof; or R 3 is a C 1-8 alkoxy optionally substituted with 1-3 of hydroxy, alkoxy, alkoxycarbonyl, phenyl, phenylcarbonyl, (alkoxyphenyl)carbonyl, (halophenyl)carbonyl, (alkylphenyl)carbonyl, or combinations thereof; or R 3 is phenyl which is optionally substituted with 1-3 of halo, cyano, aminocarbonyl, cyanoalkyl, alkyl, alkenyl, alkoxy, or combinations thereof; Each R 4 is (a) hydrogen, halo, trifluoromethyl, hydroxy, cyano, methoxy; (b) methyl, ethyl, tert-butyl, (4-methyl)pentyne-1-yl, 2-phenylethynyl, 2-(1-hydroxycyclopentane-1-yl)ethyn-1-yl, morpholinylmethyl, cyclopropylcarbonylaminomethyl; (c) tert-butylcarbonyl, cyclopropylcarbonyl, isopropylcarbonyl, ethylcarbonyl, phenylcarbonyl, furanylcarbonyl, thiophenylcarbonyl; (d) methylcarbonylamino; (e) benzo[d][1,3]dioxlyl, pyridyl, furanyl, thiophenyl; or (f) phenyl optionally substituted with one of (i) fluoro, chloro, methyl, ethyl, methoxy, cyano, trifluoromethyl, trifluoromethoxy, cyanomethyl, (2-cyano)propane-2-yl, ethenyl, 2-(1-hydroxycyclohexane-1-yl)ethyn-1-yl, (ii) aminocarbonyl, ethylaminocarbonyl, (2-methoxy)ethylaminocarbonyl, diethylaminocarbonyl, methylaminocarbonyl, thiazolylaminocarbonyl, dimethylaminocarbonyl, cyclopropylaminocarbonyl, (iii) methylsulfonyl, N-pyrrolidinylsulfonyl, isopropylsulfonyl, ethylsulfonyl, (iv) methylcarbonyl, piperidinylcarbonyl, methoxycarbonyl, pyrrolidinylcarbonyl, N-morpholinocarbonyl, (v) methylcarbonylamino; and wherein the phenyl is further optionally substituted with a substituent selected from fluoro, chloro, methyl and methoxy; L is a bond or —CH 2 —; R 10 and R′ 10 are each independently hydrogen; and n is 0-4.