Patent ID: 8324350

Claim:
An isolated, dual-specific antibody, or an antigen-binding portion thereof, with the following characteristics: a) dissociates from human IL-1α with a K D of 3×10 −7 M or less; b) dissociates from human IL-1β with a K D of 5×10 −5 M or less; and c) does not bind mouse IL-1α or mouse IL-1β, wherein the dual-specific antibody, or antigen-binding portion thereof, comprises a heavy chain variable region comprising all three complementary determining regions (CDRs) as set forth in the amino acid sequence selected from the group consisting of SEQ ID NO: 16; SEQ ID NO: 52; SEQ ID NO: 44; SEQ ID NO: 32; SEQ ID NO: 20; SEQ ID NO: 4; and a light chain variable region comprising all three CDRs as set forth in the amino acid sequence selected from the group consisting of SEQ ID NO: 36; SEQ ID NO: 24; SEQ ID NO: 28; SEQ ID NO: 40; SEQ ID NO: 12; SEQ ID NO: 48.