Patent ID: 7879840

Claim:
A compound having the formula of I-i: wherein n is 0, 1, or 2; q is 0, 1, 2, 3, or 4; each R is located at position 6, 7, 8 or 9 on the benzothiazepine ring; each R is independently selected from the group consisting of H, halogen, —OH, —NH 2 , —NO 2 , —CN, —CF 3 , —OCF 3 , —N 3 , —SO 3 H, —S(═O) 2 alkyl, —S(═O)alkyl, —OS(═O) 2 CF 3 , acyl, alkyl, alkoxyl, alkylamino, alkylthio, cycloalkyl, aryl, heterocyclyl, heterocyclylalkyl, alkenyl, alkynyl, (hetero-)aryl, (hetero-)arylthio, and (hetero-) arylamino; wherein each acyl, alkyl, alkoxyl, alkylamino, alkylthio, cycloalkyl, aryl, heterocyclyl, heterocyclylalkyl, alkenyl, alkynyl, (hetero-)aryl, (hetero-)arylthio, and (hetero-)arylamino may be substituted or unsubstituted; R 17 is selected from the group consisting of —NR 15 R 16 , —NHNR 15 R 16 , —NHOH, —OR 15 , —CH 2 X, alkenyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein each alkenyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl may be substituted or unsubstituted; X is selected from the group consisting of halogen, —CN, —CO 2 R 15 , —C(═O)NR 15 R 16 , —NR 15 R 16 , —OR 15 , —SO 2 R 7 , and —P(═O)R 8 R 9 ; R 7 is selected from the group consisting of H, —OR 15 , —NR 15 R 16 , —NHNR 15 R 16 , —NHOH, —CH 2 X, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein each alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl may be substituted or unsubstituted; R 8 and R 9 independently are selected from the group consisting of —OH, acyl, alkenyl, alkoxyl, alkyl, alkylamino, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein each acyl, alkenyl, alkoxyl, alkyl, alkylamino, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl may be substituted or unsubstituted; and R 15 and R 16 independently are selected from the group consisting of H, acyl, alkenyl, alkoxyl, OH, NH 2 , alkyl, alkylamino, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein each acyl, alkenyl, alkoxyl, alkyl, alkylamino, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl may be substituted or unsubstituted; optionally R 15 and R 16 together with the N to which they are bonded may form a heterocycle which may be substituted or unsubstituted; or an enantiomer, diastereomer, tautomer, or a pharmaceutically acceptable salt thereof.