Patent ID: RE38934

Claim:
A method of N-alkylating ureides comprising reacting a ureide of formula I with an ester of a sulfonic acid of formula III in the presence of a base in an aprotic reaction medium, to provide a corresponding alkylated ureide, wherein R 1 and R 2 are each either non-cyclic alkyl, aryl, arylalkyl, or R 1 and R 2 together form a cyclic group having a total of at least 5 atoms each of which is selected from the group consisting of carbon, nitrogen and oxygen, and wherein R 3 =H, lower alkyl, phenyl, or alkyl substituted phenyl, R 4 =H, lower alkyl, phenyl, or alkyl substituted phenyl, and R 5 =lower alkyl, phenyl, or alkyl substituted phenyl.