Patent ID: 6900319

Claim:
A compound of formula I: or a salt thereof with a physiologically tolerated acid, or a stereoisomers thereof, wherein R 1 is hydrogen; R 2 is hydrogen, C 1-4 -alkyl, phenyl, phenyl-C 1-4 -alkyl, R 18 O—CH 2 —, R 18 —CO—, R 18 —O—CH 2 —CO—, R 18 —O—CO—CO—, in which R 18 is hydrogen or C 1-4 -alkyl, or is CF 3 —CO—or C 2 F 5 —CO—; in which the substituents have the following meanings: m is 0 or 1; n is 2 or 3; R 3 is hydrogen, C 1-12 -alkyl, aryl-C 1-4 -alkyl, R 19 OOC—C 1-6 -alkyl (R 19 =hydrogen, C 1-4 -alkyl, benzyl), HO 3 S—C 1-3 -alkyl, C 1-7 -alkyl-OOC— or benzyl-OOC—, or is R 20 R 21 N—CO— (R 20 and R 21 are identical or different and are hydrogen, C 1-6 -alkyl, aryl, aryl-C 1-4 -alkyl, R 19 OOC—C 1-4 -alkyl or R 19 —NH—CO—C 1-4 -alkyl, or R 20 and R 21 are together a —(CH 2 ) 3-6 group); R 4 is hydrogen, C 1-12 -alkyl or aryl-C 1-4 -alkyl; R 5 is hydrogen or C 1-4 -alkyl; R 6 is C 5-8 -cycloalkyl, where the aliphatic rings carry from 1 to 4 C 1-4 -alkyl and/or CH 3 O groups, and/or one or more CH 2 group(s) is (are) replaced by —O—, or is phenyl which is substituted by 2 or 3 identical or different radicals from the group of C 1-4 -alkyl, CF 3 , C 1-4 -alkoxy, F and Cl, or is adamantyl, norbornyl, 1-decalinyl, 1-tetralinyl, 2-tetralinyl, 1-indanyl, 2-indanyl, diphenylmethyl, dicyclohexylmethyl, dibenzosuberyl, phenyl-C(CH 3 ) 2 —, C 1-4 -alkyl-C≡C—, (CH 3 ) 3 Si, or is R 22 O—C(R 23 R 24 )—, where R 22 is hydrogen or C 1-4 -alkyl, and R 23 and R 24 are hydrogen, C 1-4 -alkyl or phenyl, R 7 is hydrogen, C 1-12 -alkyl, C 1-20 -alkyl-CO, R 19 OOC—C 1-4 -alkyl, R 19 OOC—C 1-4 -alkyl-CO, R 20 R 21 N—CO, HO 3 S—C 1-4 -alkyl-CO, or the acyl radical of a natural or unnatural bile acid; R 8 is C 5-8 -cycloalkyl, where the aliphatic rings carry from 1 to 4 C 1-4 -alkyl and/or CH 3 O groups, and/or one or more CH 2 group(s) is(are) replaced by —O—, or is phenyl which is substituted by 2 or 3 identical or different radicals from the group of C 1-4 -alkyl, CF 3 , C 1-4 -alkoxy, F or Cl, or is adamantyl, norbornyl, 1-decalinyl, 1-tetralinyl, 2-tetralinyl, 1-indanyl, 2-indanyl, diphenylmethyl, dicyclohexylmethyl, dibenzosuberyl, phenyl-C(CH 3 ) 2 —, C 1-4 -alkyl-C≡C—, (CH 3 ) 3 Si, or R 22 O—C(R 23 R 24 )—; R 9 is C 1-4 -alkyl, phenyl or C 5-6 -cycloalkyl (R 9 can in accordance with formula IIc be a substituent on all ring positions apart from positions 1 and 2); wherein q is 1 or 2; r is 3 or 4; y is a methylene group, or is an ethylene group in which the ring resulting therefrom can carry in position 4 a hydroxyl or C 1-4 -alkoxy group, or is —CH═CH—, —CH 2 —S—, —CH 2 —O— or a propylene group, in which the rings resulting therefrom can carry on the carbon in position 3 and/or 4 a C 1-4 -alkyl group, or in which one CH 2 group can be replaced by —O—; R 11 is hydrogen or C 3-6 -cycloalkyl; R 12 is hydrogen, C 1-6 -alkyl or C 5-6 -cycloalkyl; wherein X is CH or N, and R 29 is hydrogen, C 1-4 -alkyl or C 1-4 -alkoxy-CO.