Patent ID: 7279325

Claim:
A method for identifying a compound that potentially interacts with a Ligand Binding Pocket (LBP) of Estrogen-Related Receptor 3 (ERR3), comprising the steps of: a) employing the structural coordinates of Table 1, ±1.5 Å a root mean square deviation from the backbone atoms, to generate a three-dimensional (3-D) model; b) employing the 3-D model from (a) to generate a specific ERR3 LBP three-dimensional model that consists of residues Leu 268, Cys 269, Ala 272, Glu 275, Trp 305, Leu 309, Ile 310, Arg 316, Val 313, Tyr 326, Leu 342, Leu 345, Ala 431, Val 432, His 434, Phe 435, Phe 450 and Leu 454; c) employing said 3-D model of (b) to design or select a potential compound that interacts with the LBP of ERR3; d) providing said potential compound; and e) contacting said potential compound in vitro with a complex of ERR3 and steroid receptor coactivator-1 (SRC-1) and monitoring the binding activity of the ERR3 and SRC-1 to determine the ability of said potential compound to interact with ERR3.