Patent ID: 8747902

Claim:
An orally ingestible composition comprising: (A) barrier coated particulates which provide about a twelve hour release profile which comprise: (i) a particulate drug-cation exchange resin complex-matrix comprising at least one drug bound to a pharmaceutically acceptable water insoluble cation exchange resin, and further comprising a water insoluble polymer or copolymer, or hydrophilic polymer, said particulate drug-cation exchange resin complex-(water insoluble polymer or copolymer or a hydrophilic polymer) matrix being capable of passing through a number 40 mesh screen, and (ii) a high tensile strength, water permeable, water insoluble, non ionic polymeric diffusion barrier coating which provides about a twelve hour release profile to the drug in said drug-cation exchange resin complex-(water insoluble polymer or copolymer or hydrophilic polymer) matrix, said barrier coating having an elongation factor of about 125% to about 400%, wherein said at least one drug in part (A) is amphetamine or dextro-amphetamine; and (B) at least one additional component selected from the group consisting of at least one of (iiia) an uncoated particulate dextro-amphetamine-cation exchange resin complex of a size capable of passing through a number 40 mesh screen, wherein said uncoated dextro-amphetamine-cation exchange resin complex is dextro-amphetamine bound to a pharmaceutically acceptable water insoluble cation exchange resin, (iiib) an uncoated particulate amphetamine-cation exchange resin complex of a size capable of passing through a number 40 mesh screen, wherein said uncoated amphetamine-cation exchange resin complex is amphetamine bound to a pharmaceutically acceptable water insoluble cation exchange resin, (iiic) amphetamine or a pharmaceutically acceptable salt thereof which is not complexed with an ion exchange resin, or (iiid) dextroamphetamine or a pharmaceutically acceptable salt thereof which is not complexed with an ion exchange resin.