Patent ID: 8486903

Claim:
A method of treating breast cancer in an individual, the method comprising administering to said individual an agent that down-regulates the expression, amount or activity of TAZ, wherein said administering renders a cell of said breast cancer non-cancerous, non-invasive or non-metastatic, and wherein said agent comprises an siRNA or shRNA that down-regulates TAZ expression via RNA interference comprising a sequence selected from shRNA 1 (sense oligonucleotide sequence 5′-GATGAATCCGGCCTCGGCGCC-3′), shRNA 650 (sense oligonucleotide sequence 5′-AGAGGTACTTCCTCAATCA-3′) or shRNA 652 (sense oligonucleotide sequence 5′-AGGTACTTCCTCAATCACA-3′) wherein U is substituted for T.