Patent ID: 6982268

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: W represents CH or N; R 1 represents 5- to 10-membered aryl or heteroaryl, each of which is unsubstituted or substituted with from 1 to 4 groups independently selected from R 5 ; R 2 represents C 1 –C 8 alkoxy, C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, C 3 –C 10 cycloalkyl, heterocycloalkyl, (C 3 –C 10 cycloalkyl) C 1 –C 8 alkyl, heterocycloalkyl) C 1 –C 8 alkyl, or 5- or 6-membered aryl or heteroaryl, each of which is unsubstituted or substituted with from 1 to 3 substituents independently selected from R 5 , where each heterocycloalkyl is a ring having from 3–10 ring members and contains at least one atom selected from N, S, and O, the remaining ring members being carbon atoms; R 3 and R 4 are each independently selected from: (a) hydrogen, halogen, nitro and cyano; and (b) groups of the formula: wherein: (i) G is a bond, C 1 –C 8 alkyl, —NH—, —N(R B )—, (R B )N— —O—, —C(═O)—, —C(═O)NH—, —C(═O)NR B —, —S(O) m —, —CH 2 C(═O)—, —S(O) m NH—, —S(O) m NR B —, —NHC(═O)—, —C(═NR B ), HC═N—, —NR B C(═O)—, —NHS(O) m — or NR B S(O)—; (ii) R A and R B are independently selected from C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl and 3- to 12-membered carbocycles and 3- to 12-membered heterocycles, where each of the carbocycles and heterocycles has 1 ring or 2 fused, pendant or spiro rings, each heterocycle has at least one ring that comprises at least one heteroatom selected from N, O, and S, the remaining heterocycle members being carbon atoms, each of the carbocycles and heterocycles is unsubstituted or substituted with from 1 to 4 substituents independently selected from R 5 ; and (iii) m is 0, 1 or 2; and R 5 is independently selected at each occurrence from halogen, hydroxy, nitro, cyano, amino, C 1 –C 8 alkyl, C 1 –C 8 alkoxy, mono- and di(C 1 –C 8 alkyl)amino, C 3 –C 10 cycloalkyl, (C 3 –C 10 cycloalkyl)alkyl, (C 3 –C 10 cycloalkyl)alkoxy, heterocycloalkyl, C 1 –C 8 alkenyl, C 1 –C 8 alkynyl, halo(C 1 –C 8 )alkyl, halo(C 1 –C 8 )alkoxy, oxo, amino(C 1 –C 8 )alkyl and mono- and di(C 1 –C 8 alkyl)amino (C 1 –C 8 )alkyl, where each heterocycloalkyl is a ring having from 3–10 ring members and at least one atom selected from N, S, and O, and the remaining ring members are carbon atoms.