Patent ID: 8324359

Claim:
An oxocarbonamide peptide nucleic acid having the formula (II): wherein: n is an integer from 1 to 100; each L is independently selected from the group consisting of nucleobases and DNA intercalators; each Y is independently selected from the group consisting of CH 2 CO, formula (IVa), formula (IVb), formula (IVc), formula (IVd), formula (IVe), formula (IVf), formula (IVg), and formula (IVh): wherein each W is independently selected from the group consisting of O and S, and M is selected from the group consisting of no linker, benzene, substituted benzene, formula (IVi), and formula (IVj): and where at least one Y is selected from the group consisting of formula (IVa), formula (IVb), formula (IVc), formula (IVd), formula (IVe), formula (IVf), formula (IVg), and formula (IVh); R′ is selected from the group consisting of hydrogen, alkyl, reporter ligands, carboxylates, esters, alcohols, carbamides, aldehydes, amines, amides, sulfur oxides, nitrogen oxides, and halides; and Z is selected from the group consisting of CO 2 H, NH 2 , and SH.