Patent ID: 7778782

Claim:
A method for testing the propensity of a test compound to induce a PPARα response in a test subject, the method comprising: a) administering an effective amount of a test compound to a test subject for a selected period of time; b) determining a change in expression level of each of a plurality of PPARα response indicator genes in a liver tissue sample from said test subject, wherein said plurality of PPARα response indicator genes comprises GENBANK® accession numbers: AI411979 (SEQ ID NO: 1), D00569 (SEQ ID NO: 2), K03249 (SEQ ID NO: 3), NM — 012489 (SEQ ID NO: 4), and NM — 017340 (SEQ ID NO:5); c) determining a statistical significance of the change in expression level of each of said PPARα response indicator genes; d) assigning a probability of PPARα response induction to said test compound if said plurality of PPARα response indicator genes exhibit a statistically significant change in expression level.