Patent ID: 7135493

Claim:
A compound having the following formula (I): wherein R 1 is N-containing heterocyclic ring represented by the following formula: wherein R 4 is hydrogen or a group selected from the group consisting of: (1) lower alkyl optionally substituted with di(lower)alkylamino or hydroxy, (2) lower alkoxy, (3) aryl optionally substituted with the substituent selected from the group consisting of halogen, lower alkanoyl, lower alkylsulfonyl, lower alkoxy and di(lower)alkylamino, (4) lower alkanoyl, (5) lower alkoxy-carbonyl, (6) arylcarbonyl, (7) aryl(lower)alkoxy, (8) amino optionally mono- or di-substitited with substituent(s) selected from the group consisting of lower alkyl, lower alkanoyl and cycloalkyl, (9) halo(lower)alkyl, (10) aryloxy, (11) aryl(lower)alkyl optionally substituted with hydroxy, (12) carboxyl, (13) nitro, (14) cyano, (15) halogen, (16) heteroaryl, (17) non-aromatic heterocycle optionally substituted with lower alkyl, (18) hydroxy, (19) (lower)alkylsulfonylcarbamoyl and (20) non-aromatic heterocycle carbonyl; R 5 is hydrogen or a group selected from the group consisting of lower alkyl and aryl(lower)alkyl, and R 6 , R 7 and R 8 are each hydrogen or lower alkyl, R 9 is hydrogen or a group selected from the group consisting of: (1) lower alkyl optionally substituted with di(lower)alkylamino, (2) aryl optionally substituted with lower alkoxy, (3) (lower)alkoxy-carbonyl, (4) cyano, (5) carbamoyl optionally mono- or di-substituted with (lower)alkyl, (6) halogen, (7) (lower)alkyl-carbonyl, (8) arylcarbonyl and (9) cyclo(lower)alkyl, R 10 is hydrogen or a group selected from the group consisting of: (1) (lower)alkylcarbamoyl, (2) di(lower)alkylcarbamoyl, (3) aryl optionally substituted with halogen, (4) (lower)alkoxy-carbonyl, (5) carboxy, (6) non-aromatic heterocycle carbonyl, (7) halogen, (8) (lower)alkyl optionally substituted with hydroxy, (lower)alkoxy, non-aromatic heterocycle, aryl, di(lower)alkylamino or halogen, and (9) adamantyl; R 11 is hydrogen or aryl(lower)alkyl in which the aryl portion is substituted with lower alkoxy, R 12 is hydrogen or a group selected from the group consisting of lower alkyl and aryl optionally substituted with halogen, R 13 is hydrogen or a group selected from the group consisting of lower alkyl and aryl, R 14 is hydrogen or lower alkyl, R 2 is hydroxyamino, R 3 is hydrogen or lower alkoxy, L 1 is —(CH 2 ) n — (wherein n is 1 to 5) optionally substituted with one or more substituent(s) selected from the group consisting of lower alkyl(s) and aryl(lower)alkyl, and wherein one methylene may be replaced with an oxygen atom, and L 2 is vinylene; or a salt thereof.