Patent ID: 7335470

Claim:
An array comprising: a plurality of nucleic acid segments, wherein each nucleic acid segment is immobilized to a discrete and known spot on a substrate surface to form an array of nucleic acids, and each spot comprises a segment of genomic nucleic acid selected to detect a genetic syndrome, wherein the array-immobilized genomic nucleic acid segments are covalently bound to the substrate surface through a compound having the general formula: R 1 —X—R 2 , and wherein R 1 is a cyclic ether, an aldehyde, or a chloromethylphenyl moiety; X is a moiety chemically suitable for linking the R 1 moiety to the R 2 moiety, and the R 2 moiety has the general formula wherein R 3 , R 4 and R 5 comprise identical or different alkoxy groups or chloro groups.