Patent ID: 7452911

Claim:
An alkyne compound of formula IIa: wherein R 1 and R 2 together form an alkylene bridge in such a way that R 1 R 2 N— denotes a pyrrolidine group, wherein one or more H atoms are optionally replaced by R 14 , X is —CH 2 —CH 2 —O— or —CH 2 —CH 2 —NR 4 —, wherein one or two C atoms in each case are optionally substituted with one or two identical or different substituents selected from C 1-6 -alkyl, Z is a single bond, R 4 is H or C 1-4 -alkyl, R 14 denotes C 1-4 -alkyl, C 2-4 -alkenyl, C 2-4 -alkynyl, C 3-7 -cycloalkyl, C 3-7 -cycloalkyl-C 1-3 -alkyl, hydroxy, ω-hydroxy-C 1-3 -alkyl, C 1-4 -alkoxy, ω-(C 1-4 -alkoxy)-C 1-3 -alkyl, C 1-4 -alkyl-carbonyl, carboxy, C 1-4 -alkoxycarbonyl, hydroxy-carbonyl-C 1-3 -alkyl, C 1-4 -alkoxycarbonyl-C 1-3 -alkyl, C 1-4 -alkoxy-carbonylamino, C 1-4 -alkoxy-carbonylamino-C 1-3 -alkyl, amino, C 1-4 -alkyl-amino, C 3-7 -cycloalkyl-amino, N-(C 3-7 -cycloalkyl)-N-(C 1-4 -alkyl)-amino, di-(C 1-4 -alkyl)-amino, amino-C 1-3 -alkyl, C 1-4 -alkyl-amino-C 1-3 -alkyl, C 3-7 -cycloalkyl-amino-C 1-3 -alkyl, N-(C 3-7 -cycloalkyl)-N-(C 1-4 -alkyl)-amino-C 1-3 -alkyl, di-(C 1-4 -alkyl-amino-C 1-3 -alkyl, cyclo-C 3-6 -alkyleneimino-C 1-3 -alkyl, aminocarbonyl, C 1-4 -alkyl-amino-carbonyl, C 3-7 -cycloalkyl-amino-carbonyl, N-(C 3-7 -cycloalkyl)-N-(C 1-4 -alkyl)-amino-carbonyl, di-(C 1-4 -alkyl)-amino-carbonyl, Q is CH, L 1 , L 2 , and L 3 , independently of one another are F, Cl, Br, I, OH, cyano, C 1-4 -alkyl, C 2-4 -alkynyl, C 1-4 -alkoxy, difluoromethyl, trifluoromethyl, amino, C 1-4 -alkylamino, di-(C 1-4 -alkyl)-amino, acetylamino, aminocarbonyl, difluoromethoxy, trifluoromethoxy, amino-C 1-3 -alkyl, C 1-4 -alkylamino-C 1-3 -alkyl or di-(C 1-4 -alkyl)-amino-C 1-3 -alkyl or nitro, with the proviso that a phenyl may only be monosubstituted by nitro, m, n, and p, independently of one another represent the values 0, 1 or 2, and p may also have the value 3, while in the above-mentioned groups X, R 1 , R 2 , R 4 and R 14 one or more C atoms are optionally additionally mono- or polysubstituted by F and/or one or two C atoms, independently of one another, are optionally additionally monosubstituted by Cl or Br, or a tautomer, a diastereomer, an enantiomer, a mixture thereof or a salt thereof.