Patent ID: 7288523

Claim:
A method for inhibiting Aβ fibril formation in a patient in need thereof, comprising administering to said patient a therapeutic effective amount of a compound defined by the Formula: R 1 -AA-R 2 wherein AA in said Formula corresponds to an amino acid sequence selected from the group consisting of: His-Gln-Lys-Leu-Val-Phe; His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu; His-His-Gln-Lys-Leu-Val-Phe; Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala; Val-His-His-Gln-Lys-Leu-Val-Phe; Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe; and Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val; and wherein R 1 is H or —CO—R 3 bonded at the α-amino group of the N-terminal of AA; R 2 is H or —OR 4 or NR 5 R 6 all bound to the α-carboxyl group of the α-carboxyterminal of AA; R 3 is a straight or branched carbon chain of 1-4 carbon atoms; R 4 is a straight or branched carbon chain of 1-4 carbon atoms; R 5 and R 6 independently are H, alkyl, cycloalkyl, aryl or substituted aryl or together are -(CH 2 ) n -, where n is 4-5; R 1 and R 2 together can form a hydrocarbon ring or heterocyclic ring; and said amino acids can be either D- or L-isomers.