Patent ID: 7557137

Claim:
A compound of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of —C(═O)R 1a , —S(═O)R 1a , —S(═O) 2 R 1a , —C(═O)OR 1a , —C(═O)NHR 1a , and C 1 -C 6 alkyl optionally substituted with R 1b ; R 1a is C 1 -C 6 alkyl optionally substituted with R 1b ; R 1b is independently selected from the group consisting of halogen, —CF 3 , —OCF 3 , —CO 2 R 6 , —C(═O)NR 6 R 6 , —NR 6 C(═O)R 6 , —NR 6 R 6 , —NR 6 SO 2 R 6 , —C(═O)R 6 , —S(═O)R 6 , —SO 2 R 6 , —SO 2 NR 6 R 6 , —SR 6 , —S(C 1 -C 4 haloalkyl), —OR 6 , —O(C 1 -C 4 haloalkyl), —(C 3 -C 7 )cycloalkyl, -imidazole, -thiazole, -oxazole, —(C 2 -C 6 )alkenyl, and —(C 2 -C 6 )alkynyl; R 2 is selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, and C 3 -C 6 cycloalkyl in which each group is optionally substituted with halogen, —CF 3 , —OCF 3 , —CH 3 , —CH 2 CH 3 , —OCH 3 , —OCH 2 CH 3 , or —(C 3 -C 7 )cycloalkyl; R 3 is selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, and C 2 -C 4 alkynyl optionally substituted with R 3a , or phenyl optionally substituted with R 3b ; R 3a is selected from the group consisting of R 3b , C 3 -C 6 cycloalkyl optionally substituted with R 3b , phenyl optionally substituted with R 3b , and 3,4-methylenedioxyphenyl; R 3b is independently selected at each occurrence from the group consisting of halogen, —NO 2 , —CN, —C 1 -C 4 alkyl, —OH, —OCH 3 , —OCH 2 CH 3 , —CF 3 , —OCF 3 , —SCF 3 , —C(═O)R 6 , —NR 6 C(═O)R 6 , —NR 6 SO 2 R 6 , —NR 6 R 6 , —OC(═O)NR 6 R 6 , —NR 6 C(═O)NR 6 R 6 , —C(═O)NR 6 R 6 , —C(═O)OR 6 , —SR 6 , —S(═O)R 6 , —S(═O) 2 R 6 , and —S(═O) 2 NR 6 R 6 ; R 4 is selected from the group consisting of C 1 -C 4 alkyl, C 2 -C 4 alkenyl, and C 2 -C 4 alkynyl optionally substituted with R 4a ; R 4a is selected from R 4b , or phenyl optionally substituted with R 4b ; R 4b is selected from the group consisting of halogen, —NO 2 , —CN, —NCS, —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , —CH(CH 3 ) 2 , —CF 3 , —OCF 3 , —SCF 3 , —OH, —OCH 3 , —OCH 2 CH 3 , —SH, —SCH 3 , —SCH 2 CH 3 , —CO 2 H, —CO 2 CH 3 , —CO 2 CH 2 CH 3 , —NH 2 , —NH(CH 3 ), —N(CH 3 ) 2 , —C(═O)NH 2 , —C(═O)NH(CH 3 ), —C(═O)N(CH 3 ) 2 , —C(═O)H, —C(═O)CH 3 , —NHC(═O)CH 3 , and —NHSO 2 CH 3 ; R 5 is C 1 -C 10 alkyl optionally substituted with R 5a ; R 5a is selected from the group consisting of R 5b , C 3 -C 8 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and phenyl optionally substituted with R 5b ; R 5b is selected from the group consisting of R 6 , halogen, —CN, —CF 3 , —NO 2 , —NCS, —OCF 3 , —CO 2 H, —C(═O)H, —OR 6 , —NR 6 R 6 , —OC(═O)NR 6 R 6 , —NR 6 C(═O)NR 6 R 6 , —C(═O)NR 6 R 6 , —C(═O)OR 6 , —SR 6 , —S(═O)R 6 , —S(═O) 2 R 6 , and —S(═O) 2 NR 6 R 6 ; and R 6 is independently selected at each occurrence from the group consisting of hydrogen, C 1 -C 6 alkyl and phenyl.