Patent ID: 7119205

Claim:
A compound of formula (I): or a therapeutically suitable salt, ester or prodrug thereof, wherein R 1 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, halogen, haloalkyl, trihaloalkyl, heterocycle, hydroxyalkyl, R a R b N—, R a R b Nalkyl, and R c R d NC(O)—, wherein alkyl may be optionally substituted with O═ and R t —N═; R 2 is selected from the group consisting of R f O—, HO—, R f S—, and HS—; R 3 is selected from the group consisting of alkoxycarbonyl, substituted aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, carboxy, carboxylalkyl, halogen, heteroaryl, heterocycle, heterocyclealkyl, R g R j N—, and R g R j Nalkyl, wherein cycloalkyl may be fused to an aryl ring as defined herein; R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, carboxy, carboxyalkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, hydroxyalkyl, HO—N═CH—(CH 2 ) u —, and R m R n N—; u is 0, 1 or 2; R a and R b are each individually selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkoxylcarbonyl, aryl, arylalkyl, arylcarbonyl, arylalkyloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, and heterocycleoxycarbonyl; R c and R d are each independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, haloalkyl, hydroxyalkyl, and heterocycle; R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl; R g and R j are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, and haloalkyl; R m and R n are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, heteroaryl, heterocycle, heterocyclealkyl, and haloalkyl; and R t is selected from the group consisting of hydrogen, alkyl and HO—.