Patent ID: 8324186

Claim:
A compound of Formula (I) X is H, F, OH, or NH 2 ; R 1 is —O-benzoisothiazol-3-yl, —O-benzoisoxazolyl, —O-benzothiazolyl, —O-benzoxazolyl, —O-benzofuryl, —O-indolyl, —O-benzoimidazolyl, —O-indazolyl, —O-furyl, —O-imidazolyl, —O-oxazolyl, —O-isoxazolyl, —O-thiophenyl, —O-benzothiophenyl, —O-thiazolyl, —O-isothiazolyl, —O-pyridazyl, —O-pyrazolyl, —O-pyrrolyl, —O— benzo[1,3]dioxolyl, —O-pyrimidyl, indazol-1-yl, —O-pyridyl, imidazol-1-yl, pyridon-1-yl, pyrimidon-1-yl, pyrazol-1-yl, indol-1-yl, pyridaz-1-yl, or pyrrol-1-yl; alternatively, both R 1 and X can be taken together with their attached carbon to form a ring selected from the group consisting of: wherein any R 1 group may be substituted with up to two methyl groups, or one substituent selected from the group consisting of: OC (1-4) alkyl, OC (3-6) cycloalkyl, OCH 2 CF 3 , OCH 2 Ph, F, I, CN, Cl, OCF 3 , CF 3 , CH 2 CN, C (1-4) alkyl, CH 2 CF 3 , N(C (1-4) alkyl) 2 , C (1-4) alkylOH, Si(CH 3 ) 3 , SCH 3 , S(O)CH 3 , SO 2 CH 3 , pyrrolidinyl, OH, NH 2 , NHCN, CO 2 H, CONH 2 , NHCO 2 C (1-4) alkyl, N(SO 2 CH 3 ) 2 , NHSO 2 CH 3 , NHC(O)CF 3 , NHC (1-4) alkyl, NHCO 2 H, NHCO 2 C (1-4) alkyl, NHCOC (1-4) alkyl, NHCONH 2 , NHCONHC (1-4) alkyl, and Br; R 2 is C (1-4) alkyl, NH 2 , NO 2 , NHCH 2 CH 2 OH, N(C (1-4) alkyl) 2 , N(SO 2 CH 3 ) 2 , CN, F, Cl, Br, CF 3 , cycloalkyl, heterocyclyl, OCF 3 , OCF 2 H, CF 2 H, or OC (1-4) alkyl; R 3 is H, F, Cl, CF 3 , or OC (1-4) alkyl; alternatively, R 2 and R 3 may be taken together with their attached phenyl to form a benzo[1,3]dioxolyl, 2,3-dihydro-benzofuranyl, or 2,3-dihydro-benzo[1,4]dioxinyl group; R 4 is H, OC (1-4) alkyl, or F; and tautomers, and pharmaceutically acceptable salts thereof.