Patent ID: 8557813

Claim:
A compound of formula I in which R 1 denotes H or A, R 2 denotes an unsaturated, saturated or aromatic 5- or 6-membered heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R 3 ) 2 ] n OR 3 , N═CR 3 N(R 3 ) 2 , SR 3 , NO 2 , CN, COOR 3 , CON(R 3 ) 2 , NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3 ) 2 , S(O) m A, [C(R 3 ) 2 ] n N(R 3 ) 2 , [C(R 3 ) 2 ] n Het, O[C(R 3 ) 2 ] n N(R 3 ) 2 , O[C(R 3 ) 2 ] n Het, S[C(R 3 ) 2 ] n N(R 3 ) 2 , S[C(R 3 ) 2 ] n Het, NR 3 [C(R 3 ) 2 ] n N(R 3 ) 2 , NR 3 [C(R 3 ) 2 ] n Het, NHCON(R 3 ) 2 , NHCONH[C(R 3 ) 2 ] n N(R 3 ) 2 , NHCONH[C(R 3 ) 2 ] n Het, [C(R 3 ) 2 ] n NHCO[C(R 3 ) 2 ] n N(R 3 ) 2 , [C(R 3 ) 2 ] n NHCO[C(R 3 ) 2 ] n Het, CON(R 3 ) 2 , CONR 3 [C(R 3 ) 2 ] n N(R 3 ) 2 , CONR 3 [C(R 3 ) 2 ] n NR 3 COOA, CONR 3 [C(R 3 ) 2 ] n OR 3 , CONR 3 [C(R 3 ) 2 ] n Het, COHet, COA and/or ═O, R 3 denotes H or A, R 4 , R 4 ′ each, independently of one another, denote H, Hal, A, OR 3 , CN, COOR 3 , CON(R 3 ) 2 , NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3 ) 2 or S(O) m A, Ar denotes phenyl, naphthyl or biphenyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R 3 ) 2 ] n OR 3 , [C(R 3 ) 2 ] n N(R 3 ) 2 , SR 3 , NO 2 , CN, COOR 3 , CON(R 3 ) 2 , NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3 ) 2 , S(O) m A, CO-Het, Het, O[C(R 3 ) 2 ] n —N(R 3 ) 2 , O[C(R 3 ) 2 ] n Het, NHCOOA, NHCON(R 3 ) 2 , NHCOO[C(R 3 ) 2 ] n N(R 3 ) 2 , NHCOO[C(R 3 ) 2 ] n Het, NHCONH[C(R 3 ) 2 ] n N(R 3 ) 2 , NHCONH[C(R 3 ) 2 ] n Het, OCONH[C(R 3 ) 2 ] 1 N(R 3 ) 2 , OCONH[C(R 3 ) 2 ] n Het, CONR 3 [C(R 3 ) 2 ] n N(R 3 ) 2 , CONR 3 [C(R 3 ) 2 ] n Het and/or COA, Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R 3 ) 2 ] n OR 3 , [C(R 3 ) 2 ] n N(R 3 ) 2 , SR 3 , NO 2 , CN, COOR S , CON(R 3 ) 2 , NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3 ) 2 , S(O) m A, CO-Het 1 , [C(R 3 ) 2 ] n Het 1 , O[C(R 3 ) 2 ] n N(R 3 ) 2 , O[C(R 3 ) 2 ] n Het 1 , NHCOOA, NHCON(R 3 ) 2 , NHCOO[C(R 3 ) 2 ] n N(R 3 ) 2 , NHCOO[C(R 3 ) 2 ] n Het 1 , NHCONH[C(R 3 ) 2 ] n N(R 3 ) 2 , NHCONH[C(R 3 ) 2 ] n Het 1 , OCONH[C(R 3 ) 2 ] n N(R 3 ) 2 , OCONH[C(R 3 ) 2 ] n Het 1 , CO-Het 1 , CHO, COA, ═S, ═NH, ═NA and/or ═O, Het 1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which is unsubstituted or mono- or disubstituted by A, OA, OH, Hal and/or ═O, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms are optionally replaced by F and/or in which one or two non-adjacent CH 2 groups are optionally replaced by O, NH, S, SO, SO 2 and/or by CH═CH groups, or cyclic alkyl having 3-7 C atoms, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, and n denotes 0, 1, 2, 3 or 4, or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.