Patent ID: 6911463

Claim:
A compound of formula I: wherein: the dashed line represents a single or double bond; m is 0, 1 or 2; D is NR 9 , R 1 is H, CN, halo, C 1 -C 6 alkyl, C 1 -C 4 haloalkyl, CO 2 R 10 , CONR 10 R 10 , NR 10 COR 10 , NR 10 R 10 , OR 10 , SR 10 , SOR 10 , SO 2 R 10 or SO 2 NR 10 R 10 ; R 2 is H, C 1 -C 6 alkyl or benzyl; R 3 is C 1 -C 6 alkyl or benzyl; or R 2 and R 3 combine with the carbon to which each are attached to form a C 3 -C 7 carbocyclic ring; provided that if R 3 is C 2 -C 6 alkyl or benzyl, then R 2 must be hydrogen; R 4 is H or C 1 -C 6 alkyl; R 5 forms a bond with X 2 or is H, cyano, C 1 -C 6 alkyl, CON 11 R 11 or CO 2 R 11 ; R 6 forms a bond with X 2 or is H or C 1 -C 6 alkyl; R 7 is independently at each occurrence halo, hydroxy, cyano, C 1 -C 6 alkyl, C 1 -C 4 haloalkyl or C 1 -C 6 alkoxy; R 8 is H, CO 2 R 12 , CONR 12 R 12 , CH═CHR 13 , CH 2 CH 2 R 13 , NR 12 R 12 , NR 12 SO 2 R 12 , O(CR 14 R 15 ) n R 16 , O(CR 14 R 15 ) p R 17 , SO 2 R 12 , SO 2 NR 12 R 12 , optionally substituted phenyl or optionally substituted heterocycle; R 9 forms a bond with X 2 or is H or C 1 -C 6 alkyl; R 10 , R 11 and R 12 are independently at each occurrence H, C 1 -C 6 alkyl or phenyl; or when two R 10 or two R 11 or two R 12 moieties are connected to the same nitrogen atom, then said R 10 or R 11 or R 12 moieties may combine with the nitrogen to which they are attached to form a pyrollidinyl, piperidinyl or hexamethyleneimino ring; R 13 is cyano, CO 2 R 18 , CONR 18 R 18 , CONR 18 SO 2 R 18 , SO 2 R 18 , heterocycle or optionally substituted phenyl; R 14 and R 15 are independently at each occurrence H or C 1 -C 6 alkyl; R 16 is hydrogen, CO 2 R 19 , CONR 19 R 19 , SO 2 R 19 , SO 2 NR 19 R 19 , optionally substituted phenyl or optionally substituted heterocycle, R 17 is cyano, NR 20 R 20 , NR 20 SO 2 R 20 or OR 20 ; R 18 , R 19 and R 20 are independently at each occurrence H, C 1 -C 6 alkyl or phenyl; or when two R 18 or two R 19 or two R 20 moieties are connected to the same nitrogen atom, then said R 18 or R 19 or R 20 moieties may combine with the nitrogen to which they are attached to form a pyrollidinyl, piperidinyl or hexamethyleneimino ring; n is 0, 1, 2 or 3; p is 1, 2 or 3; X is OCH 2 , SCH 2 or a bond; X 1 is a bond or (CR 21 R 22 ) q ; X 2 is a bond, CO, CONR 23 or NR 23 CO; q is 1, 2, 3, 4 or 5; R 21 and R 22 are independently at each occurrence H or C 1 -C 6 alkyl; or R21 and R22 combine with the carbon to which they are both attached to form a carbocyclic C 3 -C 7 ring; and R 23 is H or C 1 -C 6 alkyl; or a pharmaceutical salt thereof.