Patent ID: 7488734

Claim:
A method of inducing contraception comprising delivering to a female of child-bearing age a composition comprising a compound of formula I in a regimen which involves delivering a pharmaceutically effective amount of one or more selective estrogen receptor modulator selected from the group consisting of EM-800, EM-652, raloxifene hydrochloride, arzoxifene, lasofoxifene, droloxifene, tamoxifen citrate, 4-hydroxytamoxifen citrate, clomiphene citrate, toremifene citrate, pipendoxifene, idoxifene, levormeloxifene, centchroman, nafoxidene, and bazedoxifene to said female, wherein formula I is: wherein: R 1 and R 2 are joined to form —CH 2 (CH 2 ) n CH 2 —; n is 3 or 4; R 3 is H; R 4 is H; R 5 is a five membered heterocyclic ring having 1 NR 6 heteroatom and having one CN and one substituent selected from the group consisting of H, halogen, C 1 to C 3 alkyl, and CSR D ; R D is NH 2 ; R 6 is H or C 1 to C 3 alkyl; Q 1 is S; or a pharmaceutically acceptable salt, tautomer, metabolite, or prodrug thereof.