Patent ID: 8193182

Claim:
A compound of Formula I-1: or its pharmaceutically acceptable salt thereof, wherein B is a moiety of Formula II: wherein W c is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl, and q is an integer of 0, 1, 2, 3, or 4; X is a bond or —(CH(R 9 )) z —, and z is an integer of 1; Y is —N(R 9 )—; W d is: R 1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro; R 2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, alkoxy, amino, halo, cyano, hydroxy or nitro; R 3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, alkoxy, amido, amino, alkoxycarbonyl sulfonamido, halo, cyano, hydroxy or nitro; and each instance of R 9 is independently hydrogen, alkyl, or heterocycloalkyl.