Patent ID: 6884910

Claim:
A method for alleviating pain in a patient suffering therefrom comprising administering to said patient an analgesic effective amount of a compound of the formula: wherein R is aryl lower alkyl and R is unsubstituted or is substituted with at least one electron withdrawing group or electron donating group; R 1 is lower alkyl and R 1 is unsubstituted or substituted with an electron donating group or an electron withdrawing group; and R 2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, halo, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, or ZY; R 3 is lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, halo, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl or ZY; wherein R 2 and R 3 may be unsubstituted or substituted with at least one electron withdrawing group or electron donating group and wherein heterocyclic in R 2 and R 3 is furyl, thienyl, pyrazolyl, pyrrolyl, imidazolyl, indolyl, thiazolyl, oxazolyl, isothiszolyl, isoxazolyl, piperidyl, pyrrolinyl, piperazinyl, quinolyl, triazolyl, tetrazolyl, isoquinolyl, benozofuryl, benzothienyl, morpholinyl, benzoxazolyl, tetrahydrofuryl, pyranyl, indazolyl, purinyl, indolinyl, pyrazolindinyl, imidazolinyl, imidazolindinyl, pyrrolidinyl, furazanyl, N-methylindolyl, methylfuryl, pyridazinyl, pyrimidinyl, pyrazinyl, epoxy, aziridino, oxetanyl or azetidinyl; Z is O or NR 6 ′; Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, and Y may be unsubstituted or substituted with an electron donating group or an electron withdrawing group, or ZY taken together is NR 4 NR 5 R 7 , NR 4 OR 5 , or ONR 4 R 7 ; R 6 ′ is hydrogen or lower alkyl and R 6 ′ maybe unsubstituted or substituted with an electron withdrawing group or electron donating group; R 4 and R 5 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, wherein R 4 and R 5 are independently unsubstituted or substituted with an electron withdrawing group or an electron donating group; and R 7 is COOR 8 , COR 8 , hydrogen, lower alkyl, aryl, or aryl lower alkyl which R 7 maybe unsubstituted or substituted with an electron withdrawing group or electron donating group; and R 8 is hydrogen or lower alkyl, or aryl lower alkyl, and the aryl or alkyl group may be unsubstituted or substituted with an electron withdrawing group or an electron donating group; wherein the electron withdrawing group and electron donating group are selected from the group consisting of halo, nitro, lower alkenyl, lower alkynyl, formyl, aryl, trifluoromethyl, aryl lower alkanoyl, hydroxy, lower alkoxy, lower alkyl, mercapto, lower alkylthio, and lower alkyldithio.