Patent ID: 6856914

Claim:
A method of identifying associated cell signaling proteins, the method comprising: a) producing and storing a comparison value for each pair of said cell signaling proteins in response to data values representing physical properties of respective cell signaling proteins; and b) identifying cell signaling protein pairs having comparison values satisfying a condition indicative of an association between the cell signaling proteins, wherein producing a comparison value comprises producing a linkage coefficient for each pair of said cell signaling proteins, as a function of a coexpression coefficient representing a degree of coexpression of one cell signaling protein of said pair and the other cell signaling protein of said pair, and of a coregulation coefficient representing a degree of coregulation of said one cell signaling protein of said pair and said other cell signaling protein of said pair, each said linkage coefficient representing a degree of association between said one cell signaling protein and said other cell signaling protein, and wherein, producing said linkage coefficient comprises, for each said pair, dividing said coregulation coefficient by said coexpression coefficient.