Patent ID: 7744851

Claim:
A method for preparing an anhydrous 18 F-radiolabeled fluorinating agent having the formula [Q n M] x+ ( 18 F − ) x , wherein: Q is an organic moiety selected from the group consisting of alkyls, heteroalkyls, aryls, heteroaryls, alkenyls, alkynyls, and polymers; n is an integer such that [Q n M] carries at least one formal positive charge; M is a moiety capable of supporting a positive charge; and x is an integer representing the number of formal positives charge(s), +, carried by the [Q n M]; the method comprising: (a) a nucleophilic reaction of a 18 F-radiolabeled fluoride salt with an unsaturated carrier compound in an anhydrous polar aprotic solvent, wherein the unsaturated carrier compound is selected from the group consisting of: an aromatic compound, an electron deficient aromatic compound, a heteroaromatic compound, and an electron deficient heteroaromatic compound; to produce a 18 F-radiolabeled carrier compound; and (b) reacting the 18 F-radiolabeled carrier compound with a nucleophilic composition having the formula [Q n M] x+ A x ″, wherein A is nucleophile, in a second nucleophilic reaction to yield the anhydrous 18 F-radiolabeled fluorinating agent having the formula [Q n M] x+ ( 18 F − ) x .