Patent ID: 8013152

Claim:
A compound of formula I: wherein: a is 0 or an integer of from 1 to 5; each R 1 is independently selected from —C 1-5 alkyl, —C 2-5 alkenyl, —C 2-5 alkynyl, —C 3-6 cycloalkyl, -cyano, -halo, —OR 1a , —C(O)OR 1b , —SR 1c , —S(O)R 1d , —S(O) 2 R 1e , —NR 1f R 1g , —NR 1h S(O) 2 R 1i , and —NR 1j C(O)R 1k ; where each of R 1a-1k is independently —H, —C 1-5 alkyl or phenyl-C 1-5 alkyl; b is 0 or an integer of from 1 to 4; each R 2 is independently selected from —C 1-5 alkyl, —C 2-5 alkenyl, —C 2-5 alkynyl, —C 3-6 cycloalkyl, -cyano, -halo, —OR 2a , —C(O)OR 2b , —SR 2c , —S(O)R 2d , —S(O) 2 R 2e , —NR 2f R 2g , —NR 2h S(O) 2 R 2i , and —NR 2j C(O)R 2k ; where each of R 2a-2k is independently —H, —C 1-5 alkyl or -phenyl-C 1-5 alkyl; W is —O— or —NW a —, where W a is —H or —C 1-5 alkyl; c is 0 or an integer from 1 to 5; each R 3 independently is —C 1-5 alkyl or two R 3 groups are joined to form C 1-3 alkylene, C 2-3 alkenylene or oxiran-2,3-diyl; m is 0 or 1; Z is selected from —C(O)N(R 4 )— and —N(R 4 )C(O)—, where R 4 is selected from —H, —C 1-5 alkyl, and —C 3-5 cycloalkyl; s is 0, 1 or 2; Ar is a phenylene substituted with (R 5 ) q where q is 0 or an integer from 1 to 4 and each R 5 is independently selected from -halo, —OH, —C 1-5 alkyl, and —C 1-5 alkoxy; t is 0, 1 or 2; R 6 and R 7 are taken together to form: or optionally substituted with one to three —C 1-5 alkyl groups, or where: d is 1 or 2; e is 0, 1 or 2; f is 0, 1, 2 or 3; R 8 is selected from —C 1-5 alkyl and ═O; R 9 is selected from —H, —C 1-5 alkyl, hydroxyphenyl, heteroaryl, and —X 9 R 9a ; where X 9 is selected from —C 1-5 alkylene, —C(O)—, —C 1-5 alkylene-C(O)—, —C(O)—C 1-5 alkylene, —S(O 2 )—, —C 1-5 alkylene-S(O 2 )—, and —S(O 2 )—C 1-5 alkylene; and R 9a is selected from —H, —OH, —C 1-5 alkyl, —C 1-5 alkoxy, aryl, heteroaryl, heterocyclyl, and —NR 9b R 9c , where R 9b and R 9c are independently —H or —C 1-5 alkyl; wherein each alkyl and alkoxy group in R 1 , R 1a-1k , R 2 , R 2a-2k , R 5 , R 8 , R 9 , and R 9a-c is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.