Patent ID: 7345018

Claim:
A method for reducing the accumulation of an aminoglycoside in kidney cells of a human subject in need of such reduction, and thereby reducing kidney damage attributable to said accumulation, said method comprising administering to said individual, before, during or after administration of the aminoglycoside, an aminoglycoside accumulation-reducing effective amount of a substance, which substance is not itself an aminoglycoside, said substance being basic and having an amino group, and being capable of binding to a megalin receptor in kidney cells and inhibiting binding of said aminoglycoside to said receptor, said administration of the substance being at a time such that the substance competes with the aminoglycoside for said receptor, said method resulting in less kidney damage to the subject, as a result of administration of the aminoglycoside and the substance together, as compared to the administration of the same amount of the aminoglycoside alone.