Patent ID: 8912173

Claim:
A compound of the formula 1 wherein R 1 is a linear or branched C 1-6 -alkyl, wherein R 1 is substituted by R 3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkyl; a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; wherein the R 3 may optionally be substituted by one, two, three or four substituents each independently selected from the group consisting of oxo, OH, —CO—NH 2 , —CO—NH(CH 3 ), —CO—N(CH 3 ) 2 , —C 1-5 -alkyl, —C 1-3 -alkylene-CO—NH 2 , —C 1-3 -alkylene-CO—NH(CH 3 ), —C 1-3 -alkylene-CO—N(CH 3 ) 2 , —C 1-3 -alkylene-CN and —CN, and wherein R 2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; a bicyclic nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O; wherein the R 2 may optionally be substituted by one, two, three or four substituents R 4 which independently from one another are selected from the group consisting of linear or branched —O—C 1-5 -alkyl, —OH, oxo, halogen, —C 1-5 -haloalkyl, —SO 2 CH 3 , —C 1-3 -alkylene-SO 2 —C 1-3 -alkyl), —SO 2 —CF 3 , —CN, —C 3-6 -cycloalkyl, linear or branched —C 1-5 -alkyl, a four, five- or six-membered saturated heterocycle comprising one, two or three heteroatoms each independently from one another selected from the group of N, S, —SO 2 and O; —C 1-3 -alkylene-N(C 1-3 -alkyl)-CO—C 1-3 -alkyl, —NH—CO—C 1-3 -alkyl, —CO—NH(CH 3 ), —CO—NH 2 , —CO—N(CH 3 ) 2 , —O—R 5 , —CO—R 5 , —C 1-3 -alkylene-O—CO—C 1-3 -alkyl and wherein the R 4 may optionally be substituted by one or two substituents R 5 , wherein each R 5 is independently from one another selected from the group consisting of linear or branched —C 1-4 -alkyl, oxo, —C 1-3 -haloalkyl, —OH, halogen, —C 1-2 -alkylene-C 1-3 -haloalkyl, a five- or six-membered saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group of N, S and O, a three, four-, five-, six- or seven-membered cycloalkyl, a five- or six-membered heteroaryl comprising one or two heteroatoms each independently selected from the group consisting of N, O and S, wherein the R 5 may optionally be substituted by a group consisting of oxo, —C 1-3 -alkyl and —C 1-3 -haloalkyl, or a pharmacologically acceptable salt thereof.