Patent ID: 8597631

Claim:
A linear self-eliminating oligomer having the following formula (I): wherein T i (i=0 to m ) is a trigger group which can be cleaved hydrolytically, enzymatically, pH-dependently, thermally, photochemically, oxidatively or reductively; X i (i=0 to m) is NH, O or S; C is a carrier selected from the group consisting of serum proteins, antibodies or antibody fragments, synthetic polymers, dendrimers, peptides, growth factors, receptor-binding ligands, polysaccharides, microparticles and nanoparticles; Y is a single bond or a spacer group; m is 0 to 5; s is 1 to 100; n(i) (i=0 to m) is independently 1 to 30; with the proviso that n(0) is at least 2 when m=0; p(i) (i=0 to m) is independently 0 or 1; with the proviso that p(0) is 0; L i,k (i=0 to m and k=0 to n(i)) is a linker unit independently selected from one of the following structures (II), (III), (IV) or (V): B i (i=0 to m) is a blocking unit having the following structure: R 1 is selected from H or one of the following residues: R 2 is selected from H, methyl, CH 3 O, halogen, acetyl, alkoxycarbonyl, NO 2 or one of the following residues: R 3 is selected from H or one of the following residues: R 4 is selected from H, methyl, CH 3 O, halogen, acetyl, alkoxycarbonyl, NO 2 or one of the following residues: R 5 is selected from H or one of the following residues: R 6 is selected from H, methyl, CH 3 O, halogen, acetyl, alkoxycarbonyl, NO 2 or one of the following residues: R 7 is selected from H or one of the following residues: R 8 is independently selected from a linear or branched C 1-8 alkyl group, a phenyl group, a naphthyl group, a biphenyl group or a vinyl benzene group; R 9 is independently selected from hydrogen or a linear or branched C 1-8 alkyl group; R 10 is independently selected from hydrogen or a linear or branched C 1-8 alkyl group; E i,k (i=0 to m and k=0 to n(i)) is an effector group independently containing a dye, a diagnostic agent or a pharmaceutically active compound, wherein the dye, diagnostic agent or pharmaceutically active compound is bound to the linker unit L i,k via an amino, hydroxy or mercapto group; with the proviso that the linear self-eliminating oligomer contains in total at least two effector units.