Patent ID: 8748369

Claim:
A method of accelerating bone healing, growth or repair in a subject, comprising administering to the subject during or after bone injury, damage or deficiency in the subject, a composition comprising an amount of a targeted nitroxide compound effective to accelerate bone repair in the subject, wherein the targeted nitroxide compound comprises a mitochondria targeting group and a nitroxide-containing group, wherein the targeted nitroxide compound is chosen from one of: a) a compound having the structure: wherein X is R 1 is C 1 -C 6 straight or branched-chain alkyl, or a C 1 -C 6 straight or branched-chain alkyl further comprising a phenyl (C 6 H 5 ) group, that is unsubstituted or is methyl-, hydroxyl- or fluoro-substituted, R 2 and R 4 are independently selected from hydrogen, C 1 -C 6 straight or branched-chain alkyl, or a C 1 -C 6 straight or branched-chain alkyl further comprising a phenyl (C 6 H 5 ) group, that is unsubstituted or is methyl-, hydroxyl- or fluoro-substituted; R 3 is —NH—R 5 , —O—R 5 or —CH 2 —R 5 , and R 5 is an —N—O., —N—OH or N═O containing group; R is —C(O)—R 6 , —C(O)O—R 6 or diphenylphosphate, and R 6 is C 1 -C 6 straight or branched-chain alkyl or C 1 -C 6 straight or branched-chain alkyl further comprising one or more phenyl (—C 6 H 5 ) groups that are independently unsubstituted, or methyl-, ethyl-, hydroxyl- or fluoro-substituted, and wherein the compound is not XJB-5-208; b) a compound having the structure R1—R2—R3 in which R1 and R3 are the same or different and have the structure —R4—R5, in which R4 is a mitochondria targeting group and R5 is —NH—R6, —O—R6 or —CH 2 —R6, wherein R6 is an —N—O., —N—OH or N═O containing group and R4 and R5 for each of R1 and R3 may be the same or different; and R2 is a linker; or c) from 2-10 consecutive amino acids of a gramicidin S polypeptide attached to a nitroxide-containing group.