Patent ID: 8536122

Claim:
A compound of formula II (SEQ ID No. 3): wherein Xaa 7 is L-histidine, D-histidine, desamino-histidine, 2-amino-histidine, β-hydroxy-histidine, homohistidine, N α -acetyl-histidine, a-fluoromethyl-histidine, a-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine, or 4-pyridylalanine; Xaa 8 is Gly, Val, Leu, Ile, Lys, Aib, (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) carboxylic acid, (1-aminocyclopentyl) carboxylic acid, (1-aminocyclohexyl) carboxylic acid, (1-aminocycloheptyl) carboxylic acid, or (1-aminocyclooctyl) carboxylic acid; Xaa 16 is Val or Leu; Xaa 18 is Ser, Lys, or Arg; Xaa 19 is Tyr or Gln; Xaa 20 is Leu or Met; Xaa 22 is Gly, Glu, or Aib; Xaa 23 is Gln, Glu, Lys, or Arg; Xaa 25 is Ala or Val; Xaa 27 is Glu or Leu; Xaa 33 is Ala, Glu, or Arg; Xaa 33 is Val or Lys; Xaa 34 is Lys, Glu, Asn, or Arg; Xaa 35 is Gly or Aib; Xaa 36 is Arg, Gly, Lys, or is absent; Xaa 37 is Gly, Ala, Glu, Pro, Lys, or is absent; Xaa 38 is Lys, Ser, amide, or is absent; and where U is a spacer selected from where n is 12, 13, 14, 15, 16, 17, or 18, l is 12, 13, 14, 15, 16, 17, or 18, m is 0, 1, 2, 3, 4, 5, or 6, s is 0, 1, 2, or 3, p is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, or 23; and where B is an acidic group selected from