Patent ID: 7741281

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein (a) R 4 is C(O)—R 5 , C(O)—N(R 5 ) 2 , or C(O)—OR 5 ; wherein each R 5 is independently C 1-9 alkyl, heterocylclyl, or C 3-7 cycloalkyl optionally substituted with alkoxy, halo, or haloalkoxy; (b) R 6 is H; (c) R 3 and R 3′ are each independently H or methyl; (d) Q is a C 5-7 saturated or unsaturated chain, optionally containing one to three heteroatoms independently selected from O or S(O) m ; wherein m is 0, 1 or 2; (e) W is —NH—SO 2 —R 2 ; wherein R 2 is cyclopropyl or cyclobutyl optionally substituted with C 1-4 alkyl or C 7-16 alkylaryl; (f) X is O, S, SO 2 , OCH 2 , CH 2 O or NH; (g) R′ is Het, C 6-10 aryl or C 7-14 alkylaryl, each optionally substituted with one or more R a groups; or R′ is C 3-9 cycloalkyl or C 1-7 alkyl, each optionally substituted with halo, cyano, alkoxy, dialkylamino; provided that when X is O, then R′ is other than wherein R a′ is H or R a ; R x is selected from H, halo, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyloxy, aryl, and Het; R y is selected from H, halo, CF 3 , C 1-6 alkoxy, and C 3-6 cycloalkyloxy; X is selected from CH and N; and Y and Y 1 are each independently selected from CH, O, S, NH, and NR a ; Y and Y 1 are each independently selected from CH, O, S, NH, and NR a ; and z is 0, 1, 2, or 3; and (h) each R a is C 1-6 alkyl, C 1-6 alkoxy, halo, NO 2 , C 6-10 aryl, and C 7-14 alkylaryl.