Patent ID: 8658635

Claim:
A compound of formula (I): wherein R 1 is 9- or 10-membered bicyclic heteroaryl wherein the 9- or 10-membered bicyclic heteroaryl contains from one to three heteroatoms independently selected from oxygen and nitrogen and is optionally substituted by C 1-6 alkyl, C 3-6 cycloalkyl, halo, —CN, —OR 13 or —NHSO 2 R 14 ; or phenyl fused to a 5-membered heterocyclyl wherein the 5-membered heterocyclyl contains one or two heteroatoms independently selected from oxygen and nitrogen and is substituted by oxo; R 2 is 5-membered heteroaryl wherein the 5-membered heteroaryl contains from one to three heteroatoms independently selected from oxygen, nitrogen and sulphur and is optionally substituted by from one to three substituents independently selected from C 1-6 alkyl optionally substituted by from one to three fluorine atoms; C 2-6 alkenyl; C 3-6 cycloalkyl; —OR 5 ; halo; —COR 6 ; —CO 2 R 7 ; —CONR 8 R 9 ; —(CH 2 ) m NR 10 R 11 ; —CH(CH 3 )NHCOphenyl; —NHCO 2 R 12 ; —(CH 2 ) n phenyl; and 5-membered heteroaryl wherein the second 5-membered heteroaryl contains one or two heteroatoms independently selected from oxygen, nitrogen and sulphur and is optionally substituted by C 1-6 alkyl; R 3 is hydrogen or fluoro; R 4 is hydrogen or methyl; R 5 , R 7 , R 12 and R 13 are each independently hydrogen or C 1-6 alkyl; R 6 , R 18 and R 19 are each independently C 1-6 alkyl; R 8 and R 9 are each independently hydrogen or C 1-6 alkyl, or R 8 and R 9 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom; R 10 and R 11 are each independently hydrogen or C 1-6 alkyl, or R 10 and R 11 , together with the nitrogen atom to which they are attached, are linked to form a 5-, 6- or 7-membered heterocyclyl or a 10-membered bicyclic heterocyclyl wherein the 5-, 6- or 7-membered heterocyclyl or the 10-membered bicyclic heterocyclyl optionally contains an oxygen atom, a sulphur atom or a further nitrogen atom and is optionally substituted by one or two substituents independently selected from C 1-6 alkyl; C 3-6 cycloalkyl; halo; oxo; phenyl optionally substituted by halo; pyridinyl; —(CH 2 ) p OR 15 ; —(CH 2 ) q NR 16 R 17 ; —COR 18 ; and —SO 2 R 19 ; R 14 is C 1-6 alkyl or phenyl; R 15 is hydrogen, C 1-6 alkyl or —(CH 2 ) r phenyl; R 16 and R 17 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom; and m, n, p, q, r are each independently 0, 1 or 2; or a salt thereof.