Patent ID: 8026254

Claim:
A composition comprising a compound or a pharmaceutically acceptable salt of a compound of formula (Ia): wherein Ar 1 is —C 3 -C 8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R 2 groups; Ar 2 is phenyl, naphthyl, anthryl, phenanthryl or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R 2 groups; G is —H, -L-(CH 2 ) n C(O)OR 4 , -L-(CH 2 ) n R 5 , —(C 1 -C 5 alkylene)C(O)OR 4 , or —(C 1 -C 5 alkylene)R 5 ; L is —C(O)—, —S(O) 2 — or —S(O)—; R 1 is —H, —C(O)NH 2 , —C(O)NHOH, —C(O)OR 4 , —C(O)H, —CN, —(C 1 -C 4 alkyl), —C(O)NH(C 1 -C 4 alkyl), or —C(O)N(C 1 -C 4 alkyl) 2 ; R 2 and R 3 are each independently -halogen, —C 1 -C 3 alkyl, —O(C 1 -C 3 alkyl), —NH(C 1 -C 3 alkyl) or —N(C 1 -C 3 alkyl) 2 ; R 4 is —H, —C 1 -C 10 alkyl, —CH 2 O(C 1 -C 4 alkyl), —CH 2 N(C 1 -C 4 alkyl) 2 , or —CH 2 NH(C 1 -C 4 alkyl); R 5 is —NH 2 , —NHS(O) 2 R 4 , —C(O)NH 2 , —C(O)NHOH, —S(O) 2 NH 2 , —C(O)NH(C 1 -C 4 alkyl), —C(O)N(C 1 -C 4 alkyl) 2 , —S(O) 2 NH(C 1 -C 4 alkyl), —S(O) 2 N(C 1 -C 4 alkyl) 2 , —H, —OH, —CN, —C 3 -C 8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl, or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R 2 groups; m is an integer ranging from 0 to 4; n is an integer ranging from 1 to 4; p is 0 or 1; and q is an integer ranging from 0 to 3; a pharmaceutically acceptable carrier, and a therapeutic agent selected from an opioid analgesic, a non-opioid analgesic, an anti-emetic agent, and an anti-diarrheal agent.