Patent ID: 8119779

Claim:
A phosphoramidate compound, comprising the structure (IV) wherein: R 16 is a group having the structure (A) wherein: R 1 -R 4 are independently selected and R 1 is selected from the group consisting of —H, C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, C 3-30 cycloalkyl, C 3-30 cycloalkenyl, C 7-30 aralkyl, C 7-30 alkaryl and C 5-30 aryl; R 2 and R 3 are independently selected from the group consisting of —H, C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, C 3-30 cycloalkyl, C 3-30 cycloalkenyl, C 7-30 aralkyl, C 7-30 alkaryl, and C 5-30 aryl, or R 2 and R 3 together form an alkylene or heteroalkylene chain so as to provide, together with the C atom to which they are attached, a C 3-8 cycloalkyl, or C 3-8 cycloalkenyl group; R 4 is selected from the group consisting of —H, C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, C 3-30 cycloalkyl, C 3-30 cycloalkenyl, C 7-30 aralkyl C 7-30 aralkyl, C 5-30 aryl, wherein R 4 is optionally mono-, di- or tri-substituted with groups independently selected from the group consisting of —OH, menthyl, ethyl, n-propyl, isopropyl, n-butyl, methoxy, ethoxy, n-propoxy, s-propoxy, n-butoxy, t-butoxy, methoxyethoxy, methoxymethyl, ethoxymethyl, propoxymethyl, dimethoxymethyl, butoxymethyl, methoxyethyl, ethoxyethyl, phenyl, benzyl, phenylethyl, phenylopropyl, phenylbutyl, acetoxyl, propionyloxyl, butyryloxyl, benzoyloxyl,—NH 2 , methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino, methylethylamino, 2-hydroxyethylamino, di(2-hydroxyethyl)amino, piperidino, morpholino, N-methylpiperadinyl, thiomorpholino, aziridinyl, indolinyl, tetrahydroquinolinyl and halogeno; R 17 and R 17′ are independently selected from the group consisting of —H and the group (A); and R 18 is —NHC(O)CH 3 ; or a pharmaceutically acceptable salt thereof.