Patent ID: 7223745

Claim:
A compound of Formula (I): or a pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein: R 1 is C 1 –C 4 alkyl; Y is or H, CN, NO 2 , or a guanidino protecting group; Z is —CN, —C(═O)OR 5 , phthalimido, —NHSO 2 R 6 , or —NR 3 R 4 ; R 3 is H or C 1 –C 4 alkyl; R 4 is selected from the group aryl-SO 2 —, aryl-C(═O)—, aralkyl-C(═O)—, alkyl-C(═O)—, aryl-OC(═O)—, aralkyl-OC(═O)—, alkyl-OC(═O)—, aryl-NHC(═O)—, and alkyl-NHC(═O)—; wherein aryl or aralkyl is optionally substituted by one or more methyl or methoxy groups; R 5 is H, C 1 –C 6 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, wherein R 5 is optionally substituted by one or more halo, C 1 –C 4 alkyl, aryl, or heteroaryl; R 6 is C 1 –C 8 alkyl, C 2 –C 8 alkenyl, C 2 –C 8 alkynyl, wherein R 6 is optionally substituted by one or more halo, C 1 –C 4 alkyl, aryl, or heteroaryl; Q is selected from B(OR 9 ) 2 , pinanediol boronic ester, pinacol boronic ester, 1,2-ethanediol boronic ester, 1,3-propanediol boronic ester, 1,2-propanediol boronic ester, 2,3-butanediol boronic ester, 1,1,2,2-tetramethylethanediol boronic ester, 1,2-diisopropylethanediol boronic ester, 5,6-decanediol boronic ester, 1,2-dicyclohexylethanediol boronic ester, bicyclohexyl-1,1′-diol boronic ester, and 1,2-diphenyl-1,2-ethanediol boronic ester; R 9 is H, C 1 –C 4 alkyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl; m is 2, 3, or 4; and n is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14.