Patent ID: 6994686

Claim:
A system for applying a biocompatible, non-liquid barrier matrix to seal a vascular puncture site comprising a catheter device defining a catheter tube movable into association with the vascular puncture site, the catheter tube including a distal end with an outlet, the catheter device including a positioner comprising an expandable structure on the distal end of the catheter tube to locate the outlet with respect to the vascular puncture site a first dispenser containing a protein component, a second dispenser containing a polymer component comprising poly(ethylene) glycol (PEG) with a functionality of at least three, and an introducer attachable in communication with the catheter tube and including a holder to mutually support the first and second dispensers while conveying the protein and polymer components from the dispensers into the catheter tube for mixing as a result of flow through the catheter tube toward the outlet, wherein, upon mixing, the protein and polymer components chemically cross-link to form the non-liquid harder matrix at the vascular puncture site without the use of a photo initiator and ultraviolet light.