Patent ID: 8431590

Claim:
A compound of the following formula: or a pharmaceutically acceptable salt thereof or an enantiomer thereof; where each R 1 is independently halo, CF 3 , C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, OCF 3 , CN, C 1 -C 6 -alkyl-C(O)—NH—, C 1 -C 6 -alkyl-NH—C(O)—, —CH 2 —N(R 7 ) 2 , —CH 2 —O—R 8 , C 1 -C 4 —S(O) r —, COOH, or heteroaryl; R 2 is H, C 1 -C 4 -alkyl, —CH 2 C(O)OR 9 , or CH 2 C(O)N(R 9 ) 2 ; each R 3 is independently C 1 -C 6 -alkyl or hydroxy-C 1 -C 6 -alkyl; each R 4 is independently OH, F, Cl, CN, C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, or C 1 -C 4 -alkoxy; Y is —NH— or R 5 is H, OH, F, Cl, CN, CF 3 , C 1 -C 6 -alkyl, hydroxy-C 1 -C 6 -alkyl, or C 1 -C 6 -alkoxy; each R 6 is independently halo, CF 3 , C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, OCF 3 , benzyloxy, or CN; each R 7 is independently H, C 1 -C 4 -alkyl, or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group; R 8 is H, C 1 -C 6 -alkyl, benzyl, or phenyl; each R 9 is independently H, C 1 -C 6 -alkyl, or benzyl; each R 10 is independently OH, F, Cl, CN, C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, or C 1 -C 4 -alkoxy; n is 0, 1, or 2; m is 0, 1, 2, or 3; p is 0, 1, or 2; q is 0, 1, or 2; r is 0, 1, or 2; and s is 0, 1, or 2.