Patent ID: 8236835

Claim:
A compound of formula (I): wherein: X is CH or N; Y is NH, N—CH 3 , O or S; W is —N(R)C(O)—, —C(O)N(R)— or C(O)O; V is —N(R 5 )C(O)—, —C(O)N(R 5 )—, —OC(O)N(R 5 )—, —N(R 5 )C(O)O—, —N(R 5 )C(O)N(R 5 )—, —O—, —S—, —N(R 5 )—, —S(O) t —, —N(R 5 )S(O) t —, —S(O) t N(R 5 )—, —OS(O) t N(R 5 )—, —C(O)—, —OC(O)—, —C(O)O—, —N(R)C(═N(R 5a ))NR 5 —, —N(R 5 )((R 5a )N═)C—, —C(═N(R 5a ))N(R)—, ═C(R 5 )— or a direct bond; n is 0, 1, 2 or 3; p is 0 or an integer from 1 to 9; t is 1 or 2; R 1 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; or R 1 is a multi-ring structure having 2 to 4 rings wherein the rings are independently cycloalkyl, heterocyclyl, aryl or heteroaryl and wherein some or all of the rings may be fused to each other; R 2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; or R 2 is a multi-ring structure having 2 to 4 rings wherein the rings are independently cycloalkyl, heterocyclyl, aryl or heteroaryl and wherein some or all of the rings may be fused to each other; R 3 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, halo, haloalkyl, haloalkyoxy, cyano or —N(R 5 ) 2 ; each R 4 is independently alkyl, halo, haloalkyl, haloalkoxy, hydroxyl, hydroxyalkyl, alkoxy, —N(R 5 ) 2 , cycloalkylalkyl or aralkyl; or two R 4 s attached to the same carbon form an oxo while each of the remaining R 4 s are as described above; each R 5 is independently hydrogen, alkyl, aryl, heteroaryl, cycloalkyl, hydroxyalkyl, cycloalkylalkyl or aralkyl; and R 5a is hydrogen, alkyl, cycloalkylalkyl or cyano; or a pharmaceutically acceptable salt thereof.