Patent ID: 7569596

Claim:
A method for treating gastric cancer, colorectal cancer, lung cancer, breast cancer, uterus sarcoma, or leukemia, comprising administering to a subject in need thereof an effective amount of a compound of the following formula: wherein X is —NR a R b or —N═CR c R d , in which each of R a and R b , independently, is hydrogen, halo, alkyl, haloalkyl, arylalkyl, heteroarylalkyl, arylcarbonyl, heteroarylcarbonyl, arylaminocarbonyl, or arylsulfonyl, in which aryl or heteroaryl is optionally substituted with alkoxy, halo, nitro, cyano, or haloalkyl; and each of R c and R d , independently, is hydrogen; halo; alkyl; heteroaryl; phenyl optionally substituted with hydroxy, halo, alkyl, haloalkyl, alkoxy, or amino; phenylsulfonyl substituted with cyano, halo, or amino; phenylcarbonyl substituted with cyano, halo, or amino; naphthylsulfonyl substituted with cyano, halo, or amino; naphthylcarbonyl substituted with cyano, halo, or amino; or alkyl optionally substituted with halo, phenyl or imidazolyl, or phenyl or imidazolyl optionally substituted with alkyl, halo, or hydroxy; R 1 is cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocyclyl, optionally fused to aryl, heteroaryl, cycloalkyl, or heterocyclyl; hydrogen; halo; alkyl; haloalkyl; alkenyl; or alkynyl; R 2 is hydrogen, alkyl, cycloalkyl, cycloalkenyl, phenyl, thienyl, thiazolyl, anthryl, or quinolyl, optionally substituted with hydroxy, halo, cyano, alkyl, haloalkyl, nitro, or alkoxy; R 3 is hydrogen, alkyl, or phenyl optionally substituted with hydroxy, halo, alkyl, haloalkyl, cyano, nitro, or alkoxy; and R 4 is diphenyl, thienyl, pyridinyl, thiazolyl, anthryl, naphthyl, or quinolyl, optionally substituted with hydroxy, halo, alkyl, haloalkyl, nitro, or alkoxy when R 2 is thienyl, thiazolyl, anthryl, or quinolyl, optionally substituted with hydroxy, halo, alkyl, haloalkyl, cyano, nitro, or alkoxy; is diphenyl, thienyl, pyridinyl, thiazolyl, anthryl, naphthyl, or quinolyl, optionally substituted with hydroxy, halo, alkyl, haloalkyl, cyano, nitro, or alkoxy when R 2 is phenyl optionally substituted with hydroxy, alkyl, haloalkyl, or alkoxy; is pyridinyl, thiazolyl, anthryl, naphthyl, or quinolyl, optionally substituted with hydroxy, halo, alkyl, haloalkyl, nitro, or alkoxy when R 2 is phenyl optionally substituted with chloro, bromo, iodo, or nitro; is phenyl optionally substituted with hydroxy, halo, alkyl, haloalkyl, cyano, nitro, or alkoxy when R 2 is phenyl substituted with fluoro, alkyl, or haloalkyl; or is alkyl, cycloalkyl, cycloalkenyl, or heterocyclyl optionally substituted with hydroxy, halo, alkyl, cyano, nitro, haloalkyl or alkoxy when R 2 is hydrogen, alkyl, cycloalkyl, cycloalkenyl, thienyl, thiazolyl, anthryl, or quinolyl, optionally substituted with hydroxy, halo, alkyl, haloalkyl, cyano, or alkoxy.