Patent ID: 8293708

Claim:
A pharmaceutical composition comprising a pegylated growth hormone and at least one pharmaceutically acceptable excipient, wherein said pegylated growth hormone comprises a growth hormone and a PEG, wherein said growth hormone and said PEG is connected via an oxime bond, and optionally via a linker, wherein said composition does not comprise any substantial amount of carbonate and said composition has a pH from 5 to 7, wherein the PEG moiety is attached to the growth hormone at a serine in the N-terminal of said growth hormone and wherein the composition comprises: Histidine: 0.002 to 0.34 mg per mg of pegylated growth hormone Poloxamer 188: 1 to 4 mg/ml Mannitol: 10 to 30 mg/ml Phenol: 1 to 5 mg/ml pegylated growth hormone: 1 to 200 mg/ml pH: 5-7.