Patent ID: 8178543

Claim:
A compound represented by a formula: wherein R 1a is a hydrogen atom, R 2a is a C 1-8 alkyl group, a C 2-8 alkenyl group or a C 2-8 alkynyl group, each of which is substituted by substituent(s) selected from (a) hydroxy, (b) optionally halogenated C 1-4 alkyloxy, (c) —O—(CH 2 ) n —OH, (d) —O—(CH 2 ) n —O—CO—NH 2 , (e) —O—(CH 2 ) n —O—C 1-4 alkyl, (f) —O—(CH 2 ) n —SO 2 -(optionally halogenated C 1-4 alkyl), (g) —O—(CH 2 ) n —SO 2 —C 6-18 aryl, (h) —O—(CH 2 ) n —SO 2 —(CH 2 ) n —OH, (i) —O—(CH 2 ) n —NR 8 —SO 2 -(optionally halogenated C 1-4 alkyl), (j) —CO—NR 8 —(CH 2 ) n —OH, (k) —CO—NR 8 —(CH 2 ) n —SO 2 -(optionally halogenated C 1-4 alkyl), (l) —NR 6 R 7 , (m) —NR 8 —(CH 2 ) n —OH, (n) —NR 8 —(CH 2 ) n —SO 2 —C 1-4 alkyl, (o) —NR 8 —CO—(CH 2 ) n —OH, (p) —NR 8 —CO—(CH 2 ) n —O—C 1-4 alkyl, (q) —NR 8 —CO—(CH 2 ) n —SO-(optionally halogenated C 1-4 alkyl), (r) —NR 8 —CO—(CH 2 ) n —SO 2 -(optionally halogenated C 1-4 alkyl), (s) —NR 8 —CO—(CH 2 ) n —SO 2 —C 3-8 cycloalkyl, (t) —NR 8 —CO 2 —(CH 2 ) n —SO 2 —C 1-4 alkyl, (u) —NR 8 —CO—NH—(CH 2 ) n —SO 2 —C 1-4 alkyl, (v) —NR 8 —SO 2 —(CH 2 ) n —SO 2 —C 1-4 alkyl, (w) —S—(CH 2 ) n —OH, (x) —SO—(CH 2 ) n —OH, (y) —SO 2 —(CH 2 ) n —OH, and (z) —NR 8 —CO-(optionally substituted heterocyclic group), (wherein said heterocyclic group is a 5- to 8-membered heterocyclic group having 1 to 3 hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and an optionally oxidized sulfur atom, which is optionally substituted by substituents selected from the group consisting of hydroxy, C 1-4 alkyl, optionally oxidized C 1-4 alkylthio, —CO—C 1-4 alkyl, —CO—NH—C 1-4 alkyl, —CONH 2 , —SO 2 —C 1-4 alkyl, —SO 2 —NH—C 1-4 alkyl, and —SO 2 NH 2 ), wherein n is an integer of 1 to 4, R 6 and R 7 are the same or different and each is a hydrogen atom or a C 1-4 alkyl group, R 8 is a hydrogen atom or a C 1-4 alkyl group, and (CH 2 ) n is optionally substituted by C 1-4 alkyl or hydroxy, R 3a is a hydrogen atom or a C 1-6 alkyl group, B a is 1,4-phenylene group optionally substituted by 1 to 4 substituents selected from the group consisting of halogen and optionally halogenated C 1-4 alkyl, and C a is a phenyl group substituted by 1 to 5 substituents selected from the group consisting of (i) halogen, (ii) optionally halogenated C 1-4 alkyl, (iii) hydroxy-C 1-4 alkyl, (iv) a 5- to 8-membered heterocycle-C 1-4 alkyl, wherein said 5- to 8-membered heterocycle has 1 to 3 hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom, and an optionally oxidized sulfur atom, (v) optionally halogenated C 1-4 alkyloxy, (vi) cyano, and (vii) carbamoyl optionally substituted by C 1-8 alkyl or a salt thereof.