Patent ID: 8114640

Claim:
A process of preparing a compound of formula (II) comprising admixing a compound of formula (I) and a thioesterase to form the compound of formula (II), wherein X 1 is selected from the group consisting of O, NH, and S; X 4 is selected from the group consisting of OH, NH 2 , and SH; X 4 is selected from the group consisting of O, NH, and S; X 5 is independently selected from the group consisting of O, S, NH, and CR 6 ; R 2 and R 6 are each independently selected from the group consisting of hydrogen and C 1-6 alkyl; R 1 , R 3 , and R 4 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 alkylenearyl, C 1-6 alkyleneheteroaryl, hydroxyC 1-6 alkyl, thioC 1-6 alkyl, C 1-6 alkyleneCO 2 H, C 1-6 alkyleneNH 2 , C 1-6 alkyleneC(O)NH 2 , and C 1-6 alkyleneNH(NH)NH 2 ; R 5 is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; a dashed line indicates an optional cis or trans double bond; Solid Support comprises a polymer or glass substrate; n is 1, 2, 3, 4, 5, 6, or 7; and m is 0 or 1.