Patent ID: 8080575

Claim:
A method of promoting bone growth in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I: wherein each R 1 and R 2 is independently selected from the group consisting of H, halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkoxy, —OR 4 , —NR 4 R 5 , —SR 4 , —C(O)R 4 , —C(O)OR 4 , —C(O)NR 4 R 5 , —N(R 4 )C(O)R 5 , —N(R 4 )C(O)OR 5 , —N(R 4 )C(O)NR 4 R 5 , —OP(O)(OR 4 ) 2 , —S(O) 2 OR 4 , —S(O) 2 NR 4 R 5 , —CN, cycloalkyl, heterocycloalkyl, aryl and heteroaryl; each R 4 and R 5 is independently selected from the group consisting of H and C 1-6 alkyl; X is selected from the group consisting of O, S and NR 4 ; Y is selected from the group consisting of an aryl ring system having 6-10 ring members and a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each independently selected from the group consisting of N, O and S; subscript n is 1 or 2; and salts, hydrates and isomers thereof, thereby promoting bone growth in the subject.