Patent ID: 7083793

Claim:
An isolated polypeptide selected from the group consisting of: a) a polypeptide comprising an amino acid sequence that has at least 95% amino acid sequence identity with SEQ ID NO:21, wherein the polypeptide is capable of modulating phospholipase A enzyme activation; b) a polypeptide comprising the amino acid sequence of a fragment of SEQ ID NO:21 comprising at least 740 contiguous amino acids, wherein the polypeptide is capable of modulating phospholipase A enzyme activation; c) a polypeptide which has an amino acid sequence that is encoded by a nucleic acid molecule comprising a nucleotide sequence which has at least 92% nucleotide sequence identity with the nucleotide sequence of SEQ ID NO:19, wherein the polypeptide is capable of modulating phospholipase A enzyme activation; d) a polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence which has at least 93% nucleotide sequence identity with the nucleotide sequence of SEQ ID NO:20, wherein the polypeptide is capable of modulating phospholipase A enzyme activation; e) a polypeptide comprising an amino acid sequence that has at least 95% amino acid sequence identity with the amino acid sequence encoded by the cDNA insert of the plasmid encoding TANGO 243 deposited with the ATCC under Accession Number 207116, wherein the polypeptide is capable of modulating phospholipase A enzyme activation; and f) a polypeptide comprising an amino acid sequence encoded by a fragment of the cDNA insert of the plasmid encoding TANGO 243 deposited with the ATCC under Accession Number 207116, wherein the fragment encodes at least 740 contiguous amino acids and wherein the polypeptide is capable of modulating phospholipase A enzyme activation; wherein percent nucleotide sequence identity and percent amino acid sequence identity are determined over the full length of SEQ ID NO:19, 20 or 21 or over the full length of the cDNA insert of the plasmid encoding TANGO 243 deposited with the ATCC under Accession Number 207116 using the algorithm of Myers and Miller (CABIOS 4:11–17 (1988)).