Patent ID: 7427389

Claim:
A diagnostic agent comprising at least one positron emitting radiolabeled halogenated xanthene as a primary active component, said radiolabeled halogenated xanthene selected from the group consisting of radiolabeled 4′,5′-Dichlorofluorescein, radiolabeled 2′,7′-Dichlorofluorescein, radiolabeled 4,5,6,7-Tetrachlorofluorescein, radiolabeled 2′,4′,5′,7′-Tetrachlorofluorescein, radiolabeled Dibromofluorescein, radiolabeled Solvent Red 72, radiolabeled Diiodofluorescein, radiolabeled Eosin B, radiolabeled Eosin Y, radiolabeled Ethyl Eosin, radiolabeled Erythrosin B, radiolabeled Phloxine B, radiolabeled Rose Bengal, radiolabeled 4,5,6,7-Tetrabromoerythrosin, radiolabeled Mono-, Di-, or Tribromoerythrosin, radiolabeled Mono-, Di-, or Trichloroerythrosin, radiolabeled Mono-, Di-, or Trifluoroerythrosin, radiolabeled 2′,7′-Dichloro-4,5,6,7-Tetrafluorofluorescein, radiolabeled 2′,4,5,6,7,7′-Hexafluorofluorescein, radiolabeled 4,5,6,7-Tetrafluorofluorescein, radiolabeled 2′,4′,5,5′,6,7′-Hexaiodofluorescein, radiolabeled 2′,4′,5,5′,7,7′-Hexaiodofluorescein, radiolabeled 2′,4′,5′,6,7,7′-Hexaiodofluorescein, radiolabeled 2′,4′,5,5′,6,7,7′-Heptaiodofluorescein, radiolabeled 4-Chloro-2′,4′,5,5′,6,7′-hexaiodofluorescein, radiolabeled 4-Chloro-2′,4′,5,5′,7,7′-hexaiodoftuorescein, radiolabeled 4-Chloro-2′,4′,5′,6,7,7′-hexaiodofluorescein, radiolabeled 4-Chloro-2′,4′,5,5′,6,7,7′-heptaiodofluorescein, radiolabeled 4,5-Dichloro-2′,4′,5′,6,7,7′-hexaiodofluorescein, radiolabeled 4,6-Dichloro-2′,4′,5,5′,7,7′-hexaiodofluorescein, and radiolabeled 4,7-Dichloro-2′,4′,5,5′,6,7′-hexaiodofluorescein, said radiolabel comprising incorporation, into said radiolabeled halogenated xanthene, of one or more positron emitting isotope selected from the group consisting of 10 C, 11 C, 13 O, 14 O, 15 O, 17 F, 18 F, 32 Cl, 33 Cl, 34 Cl, 74 Br, 75 Br, 76 Br, 77 Br, 78 Br, 117 I, 118 I, 119 I, 120 I, 121 I, 122 I, 124 I, 126 I, and 128 I, wherein said agent is adapted to positron emission imaging of human and animal tissue.