Patent ID: 8084423

Claim:
A synthetic apolipoprotein-E mimicking polypeptide comprising an amino acid sequence selected from the group of (i) Arg-Arg-Phe-Tyr-Gly-Ser-Ile-Trp-Arg-Phe-Ile Arg-Ala-Phe (SEQ ID NO: 12) or the reverse sequence thereof, (ii) Arg-Arg-Phe-Tyr-Gly-Ser-Leu-Trp-Arg-Phe-Leu-Arg-Ala-Phe (SEQ ID NO: 139) or the reverse sequence thereof, and (iii) Arg-Arg-Phe-Tyr-Gly-Ser-Ile-Trp-Arg-Phe-Leu-Arg-Ala-Phe (SEQ ID NO: 143) or the reverse sequence thereof, wherein the polypeptide comprises an acetyl group at the N-terminus and an amide group at the C-terminus, and wherein the polypeptide is capable of forming an amphipathic α helical structure.