Patent ID: 8466200

Claim:
A method for the treatment of a disease or condition selected from the group consisting of metabolic syndrome, diabetes, prediabetes, insulin resistance, low glucose tolerance, hyperglycemia, obesity, dyslipidemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, high LDL levels, glaucoma, osteoporosis, cognitive impairment, anxiety, depression, tuberculosis, leprosy, psoriasis, hypertension, atherosclerosis and its sequelae, vascular restenosis, cardiovascular diseases, pancreatitis, and retinopathy, said method comprising administering to a patient in need thereof an effective amount of a compound of formula I wherein R 1 is H, OH, F, Br, or OR 8 , Z is O or S, R 2 is H, methyl, ethyl or isopropyl, or R 2 , Y and the N to which they are attached form a saturated C 5 -C 8 ring, optionally substituted by R 3 , R 4 and/or R 5 ; Y is a direct bond or C 1 -C 4 alkyl or C 1 -C 4 alkyloxy, W is heterocyclyl or heteroaryl, optionally substituted by R 3 , R 4 and/or R 5 ; R 3 , R 4 , R 5 are independently from each other H, Hal, OH, alkyl, C 1 -C 4 alkyloxy, benzyloxy, phenoxy, phenyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, trifluoromethylsulfanyl, dimethylamino, S(O) n (CH 2 ) m CH 3 , C 1 -C 4 alkyloxycarbonyl, C 1 -C 4 alkylcarbonyl or R 6 R 7 NC 1 -C 4 alkyloxy, n is 0-2, m is 1-3, R 6 , R 7 are independently from each other C 1 -C 4 alkyl or form together with the N atom a saturated heterocyclic ring with 4-8 C atoms, R 8 is alkyl, C(O)R 9 , C(O)NH 2 or C(O)NR 9 R 10 , R 9 is H, C 1 -C 8 alkyl or C 1 -C 8 cycloalkyl, R 10 is alkyl or the group NR 9 R 10 in C(O)NR 9 R 10 is heterocyclyl, or a pharmaceutically acceptable salt thereof.