Patent ID: 7759520

Claim:
A process for preparing a selective androgen receptor modulator (SARM) compound, said compound represented by the structure of formula XVI: wherein X is O; T is OH, OR, NHCOCH 3 , or NHCOR; Z is NO 2 , CN, COOH, COR, NHCOR or CONHR; Y is H; A is a group selected from: wherein R 2 , R 3 , R 4 , R 5 , R 6 are independently H, halogen, CN, NHCOCF 3 ; R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ; said process comprising the step of coupling an amide of formula XVII: wherein Z, Y, R 1 and T are as defined above and L is a leaving group, with a compound of formula XVIII: wherein A and X are as defined above, and wherein said coupling is done using Cs 2 CO 3 as a coupling agent.