Patent ID: 8404638

Claim:
A non-liquid formulation of a vascular endothelial growth factor (VEGF) antagonist made according to the steps of: (a) combining in a liquid solution the following excipients: (i) about 50 mg/mL of a VEGF antagonist, which is a dimer consisting of two identical polypeptides consisting of amino acids 27-457 of SEQ ID NO:4; (ii) about 10 mM histidine, pH about 6.3-6.5; (iii) about 1.5% polyethylene glycol (PEG) 3350; (iv) about 5% sucrose; and (v) about 1.5% glycine; and (b) lyophilizing the combination of step (a), wherein, following storage of the lyophilized combination obtained after step (b) at 5° C. for about 6 months, at least 98% of the VEGF antagonist is present in native conformation as measured by size exclusion chromatography upon reconstitution.