Patent ID: 8193189

Claim:
A compound of formula (II) wherein R 1 is aryl or heteroaryl, either of which is substituted with 1, 2 or 3 R 7 ; R 2 is phenyl substituted with 1, 2 or 3 R 8 ; wherein each R 7 is —W—R 10 , wherein: W is a bond or a linker comprising 1 to 20 in-chain atoms, comprising one or more linkages selected from —O—, —C(O)—, —S(O) 1 —, —N(R 11 )—, hydrocarbylene optionally substituted with 1, 2, 3, 4 or 5 R 13 , and heterocyclylene optionally substituted with 1, 2, 3, 4 or 5 R 13 ; R 10 is selected from hydrogen, except when W is a bond; hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ; and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ; R 11 is selected from R 12 , —OR 12 , —C(O)R 12 , —C(O)OR 12 and —S(O) l R 12 ; R 12 is selected from hydrogen; hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ; and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ; R 13 is selected from R 14 ; hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 14 ; and —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 14 ; R 14 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo, ═NR 15 , —OR 15 , —C(O)R 15 , —C(O)N(R 15 )R 16 , —C(O)OR 15 , —OC(O)R 15 , —C(NR 15 )N(R 15 )R 16 , —S(O) l R 15 , —S(O) 1 N(R 15 )R 16 , —N(R 15 )R 16 , —N(R 15 )N(R 15 )R 16 , —N(R 15 )C(O)R 16 and —N(R 15 )S(O) l R 16 ; R 15 and R 16 are each independently hydrogen or selected from hydrocarbyl and —(CH 2 ) k -heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C 1-6 alkyl and C 1-6 alkoxy; k is 0, 1, 2, 3, 4, 5 or 6; and 1 is 0, 1, or 2, and wherein, at least one R 8 is Y—R 17 , wherein, Y is a bond or a linker comprising 1, 2, 3 or 4 linkages independently selected from —O—, —C(O)—, —S(O) 1 —, —N(R 11 )— and C 1-6 alkylene optionally substituted with 1, 2, 3, 4 or 5 R 13 , and R 17 is heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 , and wherein R 2 optionally comprises one or more further R 8 substituents wherein said further R 8 are each independently selected from, C 1-6 alkyl, C 1-6 alkoxy and halogen, or a pharmaceutically acceptable salt thereof.