Patent ID: 8039430

Claim:
A compound of formula Ia or a pharmaceutically acceptable salt thereof, wherein Q 1 and Q 2 are each independently selected from hydrogen, C 1 -C 12 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 12 alkyloxy, nitro, halogen, hydroxyl, amino, mono or dialkylamino, carboxylic acid or a salt or ester thereof, sulphonic acid or a salt or ester thereof, phosphoric acid or a salt or ester thereof, carboxamide, sulphonamide and phosphoramide wherein each C 1 -C 12 alkyl, C 3 -C 6 cycloalkyl, or C 1 -C 12 alkyloxy is optionally substituted with hydroxyl, amino, carboxylic acid or a salt or ester thereof, sulphonic acid or a salt or ester thereof, phosphoric acid or a salt or ester thereof, or carboxamide, sulphonamide or phosphoramide; B is selected from —O—, —S—, —S(O)—, —S(O) 2 —, —NH—, and —N(C 1 -C 6 alkyl)-; R 1 is selected from hydrogen, C 1 -C 12 alkyl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 6 -C 10 aryl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, a polyoxyalkylene having from 2 to 6 carbon atoms, and when B is —S—, —S(O)—, —S(O) 2 —, —NH— or —N(C 1 -C 6 alkyl)- then R 1 may be hydroxyl; V is a linker group selected from —O—, —O-L-C(O), —O-L-NR 6 —, —C(O)—, —NR 6 —, —S(O)—, —S(O) 2 —, —O-L-S(O)—, —S(O) 2 -L-C(O)—, —S(O) 2 -L-NR 6 —, P(O) 2 O—; wherein L is selected from C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 3 -C 6 cycloalkyl, polyoxyalkylene having from 2 to 6 carbon atoms, C 6 -C 10 aryl and C 1 -C 6 alkylC 6 -C 10 aryl; and wherein R 6 is selected from H and C 1 -C 12 alkyl; S 1 and S 2 are absent; A 1 is lysine or ornithine; A 2 is arginine; S 3 is an amino acid; and T is absent or is selected from —C(O)R 8 , —C(O)OR 8 , —OR 8 , —NHR 8 , NHOR 8 , —NH—C 6 aryl-CO—R 8 , —NH—C 6 aryl-CO—NHR 8 , —NH—C 6 aryl-CONHOR 8 , —NH—C 6 aryl-CONHOH, —C(O)NHR 8 , —(NH)—SO 2 C 6 aryl, and —(NH)COR 8 , or T forms a carboxylate isostere, optionally substituted with R 8 , which replaces the carboxylic acid group of the amino acid to which T is connected; wherein R 8 is selected from hydrogen, C 1 -C 12 alkyl, C 1 -C 6 alkylC 6 -C 10 aryl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl; and wherein when T is connected to the C-terminus of an amino acid residue then the carbonyl group of the amino acid residue may be reduced to methylene.