Patent ID: 8470557

Claim:
An isolated nucleic acid molecule encoding an activated form of FV selected from the group consisting of FV-810 (SEQ ID NO: 1, lacking amino acid residues 811-1491); FV-859 (SEQ ID NO: 1, lacking amino acid residues 860-1491); FV-866 (SEQ ID NO: 1, lacking amino acid residues 867-1491); FV-902 (SEQ ID NO: 1, lacking amino acid residues 903-1491); FV-924 (SEQ ID NO: 1, lacking amino acid residues 923-1491); FV-937 (SEQ ID NO: 1, lacking amino acid residues 938-1491); FV-956 (SEQ ID NO: 1, lacking amino acid residues 957-1491); FV-1033-B58-s131 (SEQ ID NO: 1, lacking amino acids 1034-1491 with amino acid residues 900-1030 exchanged with amino acid residues 907-1037 of factor VIII of SEQ ID NO: 2); FV-1033-B58-s104 (SEQ ID NO: 1, lacking amino acids 1034-1491 with amino acid residues 907-1007 exchanged with amino acid residues 972-1075 of factor VIII of SEQ ID NO: 2); and FV-1033-B58-s46 (SEQ ID NO: 1, lacking amino acids 1034-1491 with amino acid residues 963-1008 exhcanged with amino acid residues 1032-1077 of factor VIII of SEQ ID NO: 2), wherein at least one of the arginine residues at positions 506, 306, and 679 of said activated form of FV is replaced with an amino acid other than arginine.