Patent ID: 7371382

Claim:
A method of inhibiting a function of α V β 3 , comprising contacting α V β 3 with a grafted antibody exhibiting selective binding affinity to α V β 3 , or a functional fragment thereof, comprising six CDRs, said six CDRs comprising a V H CDR1 referenced as SEQ ID NO:34, a V H CDR2 referenced as SEQ ID NOS:102 or 104, a V H CDR3 referenced as SEQ ID NO:106, a V L CDR1 referenced as SEQ ID NOS:108 or 110, a V L CDR2 referenced as SEQ ID NOS:112, and a V L CDR3 referenced as SEQ ID NOS:90, wherein binding of said grafted antibody, or a functional fragment thereof, inhibits binding activity of α v β 3 .