Patent ID: 7319099

Claim:
A compound of formula wherein Ar is unsubstituted or substituted aryl or 6-membered heteroaryl containing one, two or three nitrogen atoms, wherein the substituted aryl and the substituted heteroaryl groups are substituted by one or more substituents selected from the group consisting of hydroxy, halogen, NO 2 , CN, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl substituted by halogen, (C 1 -C 6 )-alkyl substituted by hydroxy, (CH 2 ) n —(C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy substituted by halogen, NR 7 R 8 , C(O)R 9 , SO 2 R 10 , and —C(CH 3 )═NOR 7 , or are substituted by a 5-membered aromatic heterocycle containing 1-4 heteroatoms selected from N and O, which is optionally substituted by (C 1 -C 6 )-alkyl; R 1 is hydrogen or (C 1 -C 6 )-alkyl; R 2 is hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 1 -C 6 )-alkyl substituted by halogen, (C 1 -C 6 )-alkyl substituted by hydroxy, (CH 2 ) n —(C 3 -C 7 )-cycloalkyl optionally substituted by (C 1 -C 6 )-alkoxy or by halogen, CH(CH 3 )—(C 3 -C 7 )-cycloalkyl, (CH 2 ) n+1 —C(O)—R 9 , (CH 2 ) n+1 —CN, bicyclo[2.2.1]heptyl, (CH 2 ) n+1 —O—(C 1 -C 6 )-alkyl, (CH 2 ) n -heterocycloalkyl, (CH 2 ) n -aryl or (CH 2 ) n -5 or 6-membered heteroaryl containing one, two or three heteroatoms selected from the group consisting of oxygen, sulphur or nitrogen wherein aryl, heterocycloalkyl and heteroaryl are unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxy, halogen, (C 1 -C 6 )-alkyl and (C 1 -C 6 )-alkoxy; R 3 , R 4 and R 6 are each independently hydrogen, hydroxy, halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy or O—(C 3 -C 6 )-cycloalkyl; R 5 is NO 2 , CN, C(O)R 9 or SO 2 R 10 ; R 7 and R 8 are each independently hydrogen or (C 1 -C 6 )-alkyl; R 9 is hydrogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy or NR 7 R 8 ; R 10 is (C 1 -C 6 )-alkyl optionally substituted by halogen, (CH 2 ) n —(C 3 -C 6 )-cycloalkyl, (CH 2 ) n —(C 3 -C 6 )-alkoxy, (CH 2 ) n -heterocycloalkyl or NR 7 R 8 ; n is 0, 1, or 2; or a pharmaceutically acceptable acid addition salt thereof.