Patent ID: 7056922

Claim:
A compound of the formula wherein D, E, F, G, L, T, W, X, Y and Z are each, independently, N or CH; U is N and U is single bonded to both carbons adjacent to it in the nitrogen containing ring of which it is a member; A is (CH 2 ) m wherein m is zero and the dashed lines attached to A are absent; R 1 and R 2 are selected, independently, from hydrogen, (C 1 –C 6 ) alkyl optionally substituted with from one to seven fluorine atoms, cyano, —OR 9 , and —CONHR 10 ; R 3 and R 4 are selected, independently, from hydrogen, halo, (C 1 –C 6 ) alkyl optionally substituted with from one to seven fluorine atoms, cyano, hydroxy, —CONHR 11 , —OR 12 , —NR 13 R 14 and —COR 15 ; R 5 and R 6 are selected, independently, from hydrogen, halo, (C 1 –C 6 ) alkyl optionally substituted with from one to seven chlorine atoms, cyano, hydroxy, —CONHR 16 , —OR 17 , —NR 18 R 19 , and —COR 20 , R 7 is hydrogen, (C 1 –C 6 ) alkyl optionally substituted with from one to seven fluorine atoms, or aryl selected from phenyl and naphthyl, wherein said aryl can be optionally substituted with from one to three substituents independently selected from (C 1 –C 4 ) alkyl optionally substituted with from one to three fluorine atoms, (C 1 –C 4 ) alkoxy optionally substituted with from one to three fluorine atoms, cyano, nitro, halo, hydroxy, amino, (C 1 –C 4 ) alkylamino, di[(C 1 –C 6 ) alkyl]amino, (C 1 –C 4 ) amidoamino and (C 1 –C 4 ) alkanoyl; R 8 is selected from hydrogen, cyano, (C 1 –C 6 ) alkyl optionally substituted with from one to seven fluorine atoms, —OR 9 , and —CONHR 10 ; R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 16 , R 17 , R 18 and R 19 are selected, independently, from hydrogen, (C 1 –C 6 ) alkyl optionally substituted with from one to seven fluorine atoms and, aryl wherein said aryl is selected from phenyl and naphthyl and wherein said aryl can optionally be substituted with one or more substitituents, preferably with from zero to two substituents, independently selected from (C 1 –C 4 ) alkyl optionally substituted with from one to three fluorine atoms, (C 1 –C 4 ) alkoxy optionally substituted with from one to three fluorine atoms, cyano, nitro, halo, hydroxy, amino, (C 1 –C 4 ) alkylamino, di[(C 1 –C 6 )alkyl] amino, (C 1 –C 4 ) amidoamino and (C 1 –C 4 ) alkanoyl; R 15 and R 20 are selected, independently, from NHR 21 and the group of radicals listed in the definition of R 9 through R 19 ; and R 21 is selected from the group of radicals listed in the definition of R 9 through R 19 ; or a pharmaceutically acceptable salt thereof, with the proviso that ring D, E, F, G, L and ring T, W, X, Y, and Z are each independently pyrimidyl, or phenyl rings.