Patent ID: 7482013

Claim:
An albumin fusion protein comprising a serum cholinesterase polypeptide fused to an albumin polypeptide, wherein said serum cholinesterase polypeptide is selected from: (a) a full-length serum cholinesterase; (b) a mature serum cholinesterase; and (c) a fragment of serum cholinesterase, wherein said fragment has serum cholinesterase activity; and wherein said albumin polypeptide is selected from: (i) a full-length albumin; (ii) a mature albumin; (iii) a fragment of albumin, wherein said fragment of albumin has the ability to prolong the serum half-life of the fused serum cholinesterase polypeptide compared to the unfused serum cholinesterase polypeptide; (iv) a polypeptide consisting of an amino acid sequence at least 95% identical to SEQ ID NO:18, wherein said polypeptide has the ability to prolong the serum half-life of the fused serum cholinesterase polypeptide compared to the unfused serum cholinesterase polypeptide; (v) amino acids 1 to 585 of SEQ ID NO:18; and (vi) amino acids 1 to 387 of SEQ ID NO:18.