Patent ID: 7115256

Claim:
A method for providing dopamine or a dopamine precursor to a dopamine deficient prefrontal cortex of a subject exhibiting negative symptoms of schizophrenia or cognitive defects associated with schizophrenia, comprising administering an effective amount of a cell/support complex to the prefrontal cortex of the subject's brain, wherein said cell/support complex comprises cells adhered to a support matrix, wherein said cells produce dopamine or a dopamine precursor, wherein the cells are allogeneic, non-genetically modified retinal pigment epithelial cells, wherein said support matrix is made of a material selected from the group consisting of glass, polystyrene, polypropylene, polyethylene, polyvinylidene fluoride, polyurethane, polyalginate, polysulphone, polyvinyl alcohol, acrylonitrile polymers, polyacrylamide, polycarbonate, polypentene, polypentane, nylon, magnetite, natural polysaccharide, modified polysaccharide, collagen, gelatin and modified gelatin, and wherein said negative symptoms of schizophrenia or cognitive defects associated with schizophrenia are ameliorated.