Patent ID: 7786262

Claim:
A polypeptide comprising a non-naturally-occurring monomer domain that selectively binds to IL-6, wherein the monomer domain is an LDL receptor class A monomer domain consisting of the following sequence: CX 2 X 3 X 4 QFQCX 9 SG[W,Y]C[I,L,F]X 15 X 16 X 17 W [V,L]CDGX 23 NDCEDX 29 SDEX 33 X 34 C (SEQ ID NO:2) wherein amino acids in brackets indicate alternative amino acids at a specified position; X 2 is R, L, E, P, G or A; X 3 is A, P or S; X 4 is S, D or G; X 9 is G, R or S; X 15 is P or S; X 16 is Q, R or L; X 17 is P, H or R; X 23 is D, E or K; X 29 is D, S or G; X 33 is T or A; and X 34 is N or D.