Patent ID: 8361994

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein X is O or NR 7 ; is attached to any ring carbon atom other than the carbon to which R 1 and R 2 are attached; R 1 is hydrogen, —C(O)OC 1-6 alkyl, or —C(O)OH, or together with R 2 , forms ═O; R 2 is hydrogen, or together with R 1 , forms ═O; R 4 is —C 1-6 alkyl, —CD 2 C 1-5 alkyl, —C 2-5 alkylene-OH, —C 2-5 alkylene-O—C(O)C 1-6 alkyl, —C 1-6 alkylene-aryl, or —CH 2 CH═CH 2 ; R 5 and R 6 , which are attached to any available carbon ring atom, are independently hydrogen, deuterium, —C 1-6 alkyl, —C(O)OC 1-6 alkyl, —C(O)OH, aryl, or R 5 and R 6 , when they are attached to the same carbon atom, together form ═O; R 7 is hydrogen, —C 1-6 alkyl, —C 1-6 alkylene-aryl, —C 1-6 alkyleneC(O)O—C 1-6 alkyl, —C 1-6 alkylene-CR 8 R 9 R 10 , —CN, —C(O)O—C 1-6 alkyl, —C(O)O—C 1-6 alkylene CR 8 R 9 R 10 , —C(O)C 1-6 alkyl, —C(O)OC 3-6 carbocycle, —C(O)CHF 2 , —C(O)CF 3 , —C(O)CH 2 OH, —C(O)aryl, —C(O)heteroaryl, wherein heteroaryl is an unsaturated 5- or 6-membered ring containing 1-4 heteroatoms selected from N, O and S, —C(O)C 1-6 alkyleneOH, —C(O)C 3-6 carbocycle, —C(O)NH 2 , —C(O)NHC 1-6 alkyl, —C(O)NH-adamantyl, —C(O)heterocycle, wherein heterocycle is a saturated monocyclic 5- to 8-membered ring containing 1-4 heteroatoms selected from N, O and S, or a 7- to 12-membered saturated bicyclic ring system containing 1-6 heteroatoms selected from N, O and S, —C(O)NHC 3-6 carbocycle, —C(O)N(C 1-6 alkyl)Cl 1-6 alkyl, —C(O)NHSO 2 aryl, —SOC 1-6 alkyl, —SO 2 C 1-6 alkyl, —SO 2 NH(C 1-6 alkyl), —SO 2 N(C 1-6 alkyl)(C 1-6 alkyl), —SO 2 CF 3 , —SO 2 aryl, —SO 2 heteroaryl, wherein heteroaryl is an unsaturated 5- or 6-membered ring containing 1-4 heteroatoms selected from N, O and S, aryl, an unsaturated 5- or 6-membered heteroaryl ring containing 1-4 heteroatoms selected from N, O and S, or —C 3-6 carbocycle; wherein aryl, alkyl, alkylene, carbocycle, heteroaryl, and heterocycle are unsubstituted or substituted with 1-4 groups independently selected from —CN, halogen, —CF 3 , —OCF 3 , —C(O)NH 2 , —C 1-6 alkyl, —C 3-6 carbocycle, ═O, —C(O)OC 1-6 alkyl, —COOH, —C(CH 3 ) 2 OH, —SO 2 (C 1-6 alkyl), aryl, an unsaturated 5-membered heteroaryl ring containing 1-3 nitrogen atoms, or —OC 1-6 alkyl, wherein R 8 and R 9 , together with the carbon to which they are attached, form a C 3-6 carbocycle or 4-8-membered heterocycle, and wherein R 10 is C 1-6 alkyl.