Patent ID: 7589216

Claim:
A process for preparing a compound of the formula (VIII) comprising step A: contacting a compound of the formula (I) with a compound of the formula (II) Y—O—NH 2 (II) in the presence of a carboxy activating agent, in a suitable solvent under conditions suitable to form a compound of the formula (III) followed by step B: contacting compound (III) with a compound of the formula (XIII) R′—SO 2 —X′ (XIII) in the presence of a base in a suitable solvent, under conditions suitable to form a compound of the formula (IV) followed by Step C: contacting compound (IV) with a base in a suitable solvent under conditions suitable to form a compound of the formula (V) followed by Step D: contacting compound (V) with a compound of the formula (VI) in a suitable solvent optionally in the presence of an activator under conditions suitable to form a compound of the formula (VII) followed by Step E: contacting compound (VII) with a formylating agent in a suitable solvent under conditions suitable to form compound (VIII); wherein Y is a hydroxy protecting group; Each of R 2 , R 3 , R 4 and R 5 , independently, is hydrogen or an aliphatic group; X is —CH 2 ; G is —OH or —O ⊖ M ⊕ , wherein M is a metal or an ammonium moiety; R 1 is aryl or heteroaryl; X′ is halo; R′ is alkyl or aryl; and n is 1.