Patent ID: 7560571

Claim:
A compound of formula (I): in which: 1) A and Ar are independently selected from the group consisting of substituted and unsubstituted phenyl; 2) L is NH—CO—NH; 3) Ra is selected from the group consisting of H, alkyl and cycloalkyl; 4) R1 is selected from the group consisting of: H, R, COR, and SO 2 R, in which R is chosen from H, OR″ 4 , NR″ 5 R″ 6 , (C1-C6)alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, in which R″4 is chosen from H, phenyl and alkyl, and in which R″5 and R″6 are independently selected from the group consisting of H, OR″ 4 , (C1-C6)alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, or alternatively R″5 and R″6 are linked together to form a saturated 5- to 8-membered ring containing from 0 to 3 hetero atoms chosen from O, S and N; 5) X is chosen from CR3 and N; 6) R2 and R3 are independently selected from the group consisting of: H, halogen, R′2, CN, O(R′2), OC(O)(R′2), OC(O)N(R′2)(R′3), OS(O 2 )(R′2), N(R′2)(R′3), N═C(R′2)(R′3), N(R′2)C(O)(R′3), N(R′2)C(O)O(R′3), N(R′4)C(O)N(R′2)(R′3), N(R′4)C(S)N(R′2)(R′3), N(R′2)S(O 2 )(R′3), C(O)(R′2), C(O)O(R′2), C(O)N(R′2)(R′3), C(═N(R′3))(R′2), C(═N(OR′3))(R′2), S(R′2), S(O)(R′2), S(O 2 )(R′2), S(O 2 )O(R′2), and S(O 2 )N(R′2)(R′3); in which each R′2, R′3, and R′4 is independently selected from the group consisting of H, alkyl, alkylene, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, substituted alkyl, substituted alkylene, substituted alkynyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl and substituted heterocyclyl; in which, when R′2 and R′3 are each other than H and simultaneously present on R2 or on R3, they may be linked together to form a ring containing from 0 to 3 hetero atoms chosen from O, S and N; or a pharmaceutically acceptable salt thereof wherein the compound may be in achiral form, or in racemic form or enriched in one stereoisomer or enriched in one enantiomer.