Patent ID: 8614341

Claim:
A method for preparing amorphous silibinin comprising the following steps: A.) extracting silibinin with ethyl acetate a solvent having a dipole moment of less than 2 Debye, B.) separating the solvent phase from solid residues, C.) concentrating the solvent phase at a temperature of less than 60° C., D.) combining the concentrate obtained in step C.) with ethanol and then combining it with hexane, concentrating the mixture, and distilling hexane off from said concentrated mixture, E.) concentrating the intermediate product obtained in step D.), F.) separating the solid phase, G.) dissolving the solid phase obtained in step F.) with ethanol, H.) adding activated charcoal, I.) separating the charcoal from the liquid phase, concentrating the liquid and crystallizing silibinin therefrom, J.) separating the crystals obtained in step I.) from the liquid phase, and if required, repeating steps G.), I.), J.) in order to enrich silibinin to a content of more than 95% by weight, K.) optionally, filtrating, washing, drying and, if required, repeating these steps, L.) combining the material obtained in step K.) with anhydrous alcohol, refluxing, cooling to 40° C., and either concentrating under vacuum or spray drying to obtain an amorphous-like fine powder, M.) drying, milling, and homogenizing the obtained amorphous-like fine powder; wherein the starting material is milk thistle or a part thereof.