Patent ID: 8299245

Claim:
A method for producing a 4-amino-6-alkynyloxypyrimidine compound (I) represented by the formula (I): wherein R 1 , R 2 , R 3 and R 4 are as defined below, which comprises reacting a compound (II) represented by the formula (II): wherein R 1 represents a hydrogen atom or a halogen atom, with a compound (III) represented by the formula (III): wherein R 2 represents a hydrogen atom or a methyl group, in the presence of an organic base and potassium carbonate, in an alkylbenzene to give a compound (IV) represented by the formula (IV): wherein R 1 and R 2 are as defined above, and the compound (IV) being without performing isolation, and then reacting the resultant compound (IV) with a compound (V) represented by the formula (V) or a salt thereof: wherein R 3 and R 4 are combined to form a C4-C7 polymethylene group, in which the C4-C7 polymethylene group may be substituted with one or more substituents selected from the group consisting of a halogen atom, a lower alkyl group substituted with halogen atom(s) and a lower alkyl group.