Patent ID: 7045298

Claim:
A method for identifying or screening an agonist for, or an antagonist to, human peroxisome proliferator-activated receptor γ (PPARγ), characterized by detecting a ligand-dependent interaction between human PPARγ and CREB-binding protein (CBP), and measuring the effect of a substance to be tested on said interaction, wherein the effect of the substance is determined as follows: i) when the ligand-dependent interaction between PPARγ and CBP occurs in the presence of the substance tested, then the substance is identified or selected as an agonist for PPARγ; and ii) when the interaction between PPARγ and CBP that occurs in the presence of a true ligand or an agonist is inhibited by the existence of the substance tested, then the substance is identified or selected as an antagonist for PPARγ.