Patent ID: 8513429

Claim:
A method of preparing a compound of formula: wherein R 1 is hydrogen or lower alkyl; R 2 is a substituted or unsubstituted aryl, heteroaryl, arylalkyl, or heteroarylalkyl moiety; R 5 and R 6 are each independently hydrogen or a protecting group; X is O, S, C(R 7 ) 2 , or NR 7 , wherein each occurrence of R 7 is independently hydrogen or lower alkyl; R B is, independently for each occurrence, hydrogen; halogen; —OR B′ ; —SR B′ ; —N(R B′ ) 2 ; —CY 3 , —CHY 2 , —CH 2 Y, where Y is F, Br, Cl, I, OR B′ , NHR B′ , N(R B′ ) 2 , or SR B′ ; —C(O)OR B′ ; —C(O)R B′ ; —CONHR B′ ; —O(C═O)R B′ ; —O(C═O)OR B′ ; —NR B′ (C═O)R B′ ; N 3 ; N 2 R B′ ; cyclic acetal; or cyclic or acyclic, linear or branched aliphatic, heteroaliphatic, aryl, or heteroaryl, optionally substituted with one or more of hydrogen; halogen; —OR B′ ; —SR B′ ; —N(R B′ ) 2 ; —C(O)OR B —C(O)R B′ ; —CONHR B′ ; —O(C═O)R B′ ; —O(C═O)OR B′ ; —NR B′ (C═O)R B′ ; N 3 ; N 2 R B′ ; cyclic acetal; or cyclic or acyclic, linear or branched substituted or unsubstituted aliphatic, heteroaliphatic, aryl, or heteroaryl moiety; or is an epothilone, desoxyepothilone, or analogues thereof; or is a polymer; carbohydrate; photoaffinity label; or radiolabel; wherein each occurrence of R B′ is independently hydrogen; a protecting group; a linear or branched, substituted or unsubstituted, cyclic or acyclic, aliphatic, heteroalliphatic, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, or heteroarylalkynyl moiety; and m is 1, 2, 3, or 4, the method comprising steps of: subjecting a compound of the formula: to conditions of a ring closing metathesis reaction.