Patent ID: 8658427

Claim:
A method of determining whether a compound is capable of inducing increased peroxisomal proliferation in a subject comprising: (a) selecting a male or female subject brought into contact with a compound suspected to be capable of inducing increased peroxisomal proliferation; (b) obtaining a body fluid test sample from the male or female subject; (c) determining from the body fluid test sample from the male subject the amount of at least five of the following analytes Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyproline, or determining from the body fluid test sample from the female subject the amount of at least five of the following analytes Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Linoleic acid (C18:cis[9,12]2), 14-Methylhexadecanoic acid, gamma-Linolenic acid (C18:cis[6,9,12]3), 16-Methylheptadecanoic acid, Threonic acid, Cytosine, Phosphatidylcholine (C18:0/C22:6); (d) comparing the amounts determined in step (c) to corresponding reference results, wherein the reference results comprise (i) reference results obtained from one or more samples derived from one or more subjects which has been brought into contact with Benzylbutyl Phthalate, Fenofibrate, Clofibrate, Fenoforbrate, Diethylhexylphthalate or Wy 14643, (ii) reference results obtained from one or more samples derived from one or more subjects which has not been brought into contact with Benzylbutyl Phthalate, Fenofibrate, Clofibrate, Fenoforbrate, Diethylhexylphthalate or Wy 14643, (iii) reference results obtained from one or more samples derived from one or more subjects which suffers from increased peroxisomal proliferation, or (iv) reference results obtained from one or more samples derived from one or more subjects known to not suffer from increased peroxisomal proliferation; and (e) based on the comparison of step (d), determining whether the compound is capable of inducing increased peroxisomal proliferation.