Patent ID: 7053087

Claim:
A compound of formula (I), or a solvate or pharmaceutically acceptable salt thereof: wherein, independently at each occurrence, n is selected from 1, 2, 3 and 4; X is a direct bond, Y is a direct bond; R 13 is selected from hydrogen, C 1 –C 6 alkyl, C 3 –C 8 cycloalkyl, aryl, and benzyl; R 1 and R 2 are taken together with the nitrogen atom to which they are directly attached in formula (I) to form a morpholinyl ring and where any one or more of the carbon ring atoms in the morpholinyl ring may be substituted with one or two substituents selected from hydrogen, hydroxy, C 1 –C 3 hydroxyalkyl, oxo, C 2 –C 4 acyl, C 1 –C 3 alkyl, C 2 –C 4 alkylcarboxy, C 1 –C 3 alkoxy, C 1 –C 20 alkanoyloxy, or may be substituted to form a spiro five- or six-membered heterocyclic ring containing one or two heteroatoms selected from oxygen and sulfur; and any two adjacent carbon ring atoms in the morpholinyl ring may be fused to a C 3 –C 8 carbocyclic ring; R 3 and R 4 are independently attached to the cycloalkyl ring shown in formula (I) at other than the 1 and 2 positions and are independently selected from hydrogen, hydroxy, C 1 –C 6 alkyl, and C 1 –C 6 alkoxy; R 5 is hydrogen, C 1 –C 6 alkyl, aryl and benzyl; and A is selected from C 5 –C 12 alkyl, a C 3 –C 13 carbocyclic ring, and a ring system of formulae (III): where R 7 , R 8 and R 9 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 –C 7 alkanoyloxy, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, C 2 –C 7 alkoxycarbonyl, C 1 –C 6 thioalkyl, aryl and N(R 15 ,R 16 ) where R 15 and R 16 are independently selected from hydrogen, acetyl, methanesulfonyl, and C 1 –C 6 alkyl; including isolated enantiomeric, diastereomeric and geometric isomers thereof, and mixtures thereof.