Patent ID: 8003955

Claim:
A sample manipulation device, comprising an observation unit which is used to observe a sample and to select a target position at which a portion to be removed from the sample is located, a specimen stage which receives the sample, a manipulation tool, which is spatially shiftable relative to the observation unit and comprises an exchangeable manipulation tip by which said portion is removed from said sample, a control unit which controls the shifting of the manipulation tool; and an optical position measurement unit which is connected to the control unit, wherein the position measurement unit and the observation unit are each provided as microscopes, the specimen stage being arranged between the observation unit and the optical position measurement unit and the position measurement unit comprising an objective having a depth of focus on the order of magnitude of the manipulation tip; and wherein the position measurement unit is used to determine the actual position of the manipulation tip so that specific shifting of the manipulation tip to the target position can be carried out by the control unit.