Patent ID: 8334313

Claim:
A compound having the structure: or a pharmaceutically acceptable salt, hydrate, solvate or stereoisomer thereof, wherein: X is C(═O), S, S(═O) or S(O) 2 ; Y is aryl substituted with at least one heteroaryl or heterocyclo group, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclo; R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or substituted or unsubstituted aryl; n is an integer ranging from 0-4; R 1 and R 2 are each independently substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, —(CH 2 ) m —W, carboxyalkyl, alkylcarbonyl, alkyloxyalkyl, alkyloxycarbonyl, arylalkyl, or R 1 and R 2 together with the atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic, or heteroaryl ring or R 1 and R 2 together form: W is at each occurrence independently hydrogen, halogen, hydroxy, alkoxy, carboxy, aldehyde, NH 2 , NR 14 R 14′ , nitro, cycloalkyl, heteroaryl, heteroarylalkyl; where (i) each occurrence of R 14 and R 14′ is independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or CF 3 ; or (ii) R 14 and R 14′ , together with the nitrogen atom to which they are bonded, join to form an optionally substituted heterocyclic ring containing from 5 to 8 ring atoms of which from 1 to 3 are heteroatoms; m is an integer ranging from 1-4; and R 16 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, carboxy, alkylcarboxy, carbonyl, alkylcarbonyl, substituted or unsubstituted aryl, alkylaryl, substituted or unsubstituted heterocyclo, substituted or unsubstituted heteroaryl, cyano, nitro, sulfonyl, alkoxy, haloalkoxy, alkylthio, alkylamino, alkoxycarbonyl, aryloxy, arylalkyloxy, arylalkyl, cycloalkylalkyloxy, cycloalkyloxy, alkoxyalkyl, alkoxyalkoxy, alkylamino or aminoalkoxy.