Patent ID: 6906094

Claim:
A compound of Formula I: wherein: R is OH, O—C 1-4 alkyl, or halo; X is R 1 , OR 1 , SR 1 , NHR 1 , or NR 1 R 2 , wherein R 1 and R 2 are independently selected from C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, benzyl, C 3 -C 7 cycloalkyl, and phenyl, wherein: the alkyl, alkenyl, alkynyl, benzyl, and phenyl groups are optionally substituted with from 1 to 5 substituents independently selected from halo, NHR 3 , CF 3 , C 1 -C 6 alkyl, OR 4 , CO 2 R 3 , NO 2 , and SR 3 , wherein R 3 and R 4 are independently H or C 1 -C 6 alkyl; W and V are independently SO 2 or C═O; R 5 is H, C 1 -C 6 alkyl, or benzyl, wherein benzyl is optionally substituted with R 1 , wherein R 1 is as defined above, or R 5 is a pharmaceutically acceptable cation; Y is NR 6 or O, wherein R 6 is H or C 1 -C 6 alkyl; Z is 2-indolyl, or 3-indolyl, which are optionally substituted with from 1 to 4 substituents independently selected from C 1 -C 6 alkyl, fluoro, chloro, bromo, iodo, nitro, NHR 7 , NR 7 R 8 , and OR 7 , wherein R 7 and R 8 are independently H or C 1 -C 6 alkyl; wherein: each hydrocarbyl above is optionally substituted with from 1 to 3 substituents independently selected from halo, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, phenyl, hydroxyl, amino, (amino)sulfonyl, N-acetyl, O-acetyl, C 1 -C 6 thioalkyl, C 1 -C 6 alkoxy, COOH, COO(C 1 -C 6 allyl), SO 3 Na, SO 3 H, SO 2 NH 2 , cyano, CH 2 NH 2 , acetyl, di(C 1 -C 6 alkyl)amino, and nitro, wherein the alkyl, cycloalkyl, alkenyl alkynyl, and phenyl substituents may be optionally substituted with from 1 to 3 substituents independently selected from halo, C 1 -C 6 alkyl, hydroxyl, amino, and nitro; and pharmaceutically acceptable salts thereof.