Patent ID: 8669227

Claim:
A water soluble non-covalent complex between an insulin and a polysaccharide comprising carboxyl functional groups, wherein said polysaccharide is a polysaccharide functionalized with at least one phenylalanine (abbreviated Phe), said phenylalanine being grafted or bonded onto the polysaccharide by coupling with an acid group, said acid group being borne by a linker arm R bonded to the polysaccharide via a group F, said group F resulting from coupling between the linker arm R and an —OH group of the polysaccharide and/or borne by the polysaccharide comprising carboxyl functional groups, wherein: F is either an ester, thioester, carbonate, carbamate or ether group; R is a chain comprising between 1 and 18 carbons, being optionally branched and/or unsaturated, comprising one or more heteroatoms, and having at least one carboxyl group or a salt thereof prior to attachment of Phe, or a chain, not substituted with Phe, comprising between 1 and 18 carbons, being optionally branched and/or unsaturated, comprising one or more heteroatoms, and having at least one carboxyl group or a salt thereof; and Phe is a residue of phenylalanine, L or D enantiomer, or alkali metal cation salts thereof, produced from coupling between the amine of the phenylalanine and at least one acid borne by the group R and/or an acid borne by the polysaccharide comprising carboxyl functional groups.