Patent ID: 7767201

Claim:
A method for inducing the formation and maturation of new blood vessels in a tissue of a patient that requires angiogenesis, the method comprising: simultaneously injecting directly into an artery of said tissue, cells in about a 1:1 ratio i) autologous smooth muscle cells comprising a nucleic acid construct comprising a polynucleotide sequence encoding vascular endothelial growth factor (VEGF) operably linked to a promoter such that said smooth muscle cells over-express VEGF; and, ii) autologous endothelial cells comprising a nucleic acid construct comprising a polynucleotide sequence encoding angiopoietin-1(Ang-1) operably linked to a promoter such that said endothelial cells over-express Ang-1, thereby inducing the formation and maturation of new blood vessels in the tissue of said patient.