Patent ID: 8574551

Claim:
A method of inhibiting or reducing nephrotoxicity associated with an iodinated contrast agent, the method comprising: administering to a subject in need thereof a first pharmaceutical composition comprising an anionically substituted cyclodextrin of the formula: cyclodextrin-[(O—R—Y) − (Me) + ] n where R is selected from the group consisting of straight chained or branched C 1-10 alkyl, alkenyl or alkynyl; Y is an anionic group selected from COO, SO 3 , SO 4 , PO 3 H or PO 4 ; Me is a pharmaceutically acceptable cation; and n is a whole number greater than 1, and administering to the subject a second pharmaceutical composition comprising an iodinated contrast agent selected from iohexyl, ioversol, diatrizoate meglumine and ioxaglate; wherein the molar ratio of agent: cyclodextrin is from 2:1 to 50:1.