Patent ID: 7449475

Claim:
A compound of formula wherein m is 0, 1, 2, 3 or 4; each R 1 independently represents halogen, cyano, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy or sulphonamido; either X represents a bond, —CH 2 —, —O— or —C(O)— and Y represents a bond, —CH 2 —, —O— or —C(O)—, or X and Y together represent a group —CH═C(CH 3 )— or —C(CH 3 )═CH—, and Z represents a bond, —O—, —NH— or —CH 2 —, provided that only one of X, Y and Z can represent a bond at any one time and provided that X and Y do not both simultaneously represent —O— or —C(O)—; n is 0, 1 or 2; each R 2 independently represents halogen or C 1 -C 6 alkyl; q is 0 or 1; R 3 represents —C(O)NR 11 R 12 or —COOR 12a ; R 4 , R 5 , R 6 , R 7 and R 8 each independently represent a hydrogen atom or a C 1 -C 6 alkyl group; t is 0, 1 or 2; each R 9 independently represents halogen, cyano, hydroxyl, carboxyl, C 1 -C 6 alkoxy, C 1 -C 6 alikoxycarbonyl, C 1 -C 6 haloalkyl, or C 1 -C 6 alkyl optionally substituted by at least one substituent selected from carboxyl and C 1 -C 6 alkoxycarbonyl; R 11 and R 12 each independently represent (i) a hydrogen atom, (ii) a 3- to 6-membered saturated or unsaturated ring optionally comprising at least one ring heteroatom selected from nitrogen, oxygen and sulphur and optionally further comprising a bridging group, the ring being optionally substituted with at least one substituent selected from halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl and C 1 -C 6 haloalkyl, (iii) a C 1 -C 6 alkyl group optionally substituted by at least one substituent selected from halogen, amino, hydroxyl, C 1 -C 6 haloalkyl, carboxyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 alkylcarbonylamino and a 3- to 6-membered saturated or unsaturated ring optionally comprising at least one ring heteroatom selected from nitrogen, oxygen and sulphur and optionally further comprising a bridging group, the ring being optionally substituted with at least one substituent selected from halogen, hydroxyl, oxo (═O), C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl and C 1 -C 6 haloalkyl, or (iv) C 1 -C 6 alkylsulphonyl, or R 11 and R 12 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring that optionally further comprises a ring nitrogen, oxygen or sulphur atom and that is optionally fused to a benzene ring to form a 8- to 11-membered ring system, the heterocyclic ring or ring system being optionally substituted with at least one substituent selected from halogen, hydroxyl, amido, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkylamino, di-C 1 -C 6 alkylamino, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkylcarbonylamino, C 1 -C 6 alkylaminocarbonyl, di-C 1 -C 6 alkylaminocarbonyl, phenyl, halophenyl, phenylcarbonyl, phenylcarbonyloxy and hydroxydiphenylmethyl; R 12a represents a hydrogen atom or a C 1 -C 6 alkyl group; or a pharmaceutically acceptable salt thereof.