Patent ID: 8871213

Claim:
A chimeric or fusion protein for inducing an immune response to P. gingivalis , the protein comprising a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein: (A) said first peptide comprises a region of a P. gingivalis trypsin-like enzyme selected from the group consisting of the amino acid sequence that is the same as, or at least 90% homologous to, the sequence shown in any one of SEQ ID NOs: 1-34; and (B) said second peptide or polypeptide comprises an adhesin domain of P. gingivalis , or fragment thereof, selected from the group consisting of: (i) the amino acid sequence that is the same as, or at least 90% homologous to the sequence of an adhesin domain of the Lys-X-proteinase of P. gingivalis shown in any one of SEQ ID NOs: 35-37 and 40-43; and (ii) the amino acid sequence that is the same as, or at least 90% homologous to the sequence of an adhesin domain of the Arg-X-proteinase of P. gingivalis shown in any one of SEQ ID NOs: 38-39 and 44-46; (iii) the amino acid sequence that is the same as, or at least 90% homologous to the sequence of a HagA adhesin domain of P. gingivalis shown in any one of SEQ ID NOs: 80-82; and (iv) the amino acid sequence that is the same as or at least 90% homologous to the sequence shown in any one of SEQ ID NOs: 69-79 and 83 to 85.