Patent ID: 7947686

Claim:
A compound of formula (I): wherein: R is an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl or aryl; R1 is selected from hydrogen, halogen, nitro, NHCOR4, NHSO 2 R10, NR5R6, OR7, R8R9N—C 1 -C 6 alkyl, R7O—C 1 -C 6 alkyl and an optionally further substituted straight or branched C 1 -C 6 alkyl, wherein: R4 is selected from hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl, aryl, NR8R9, R8R9N—C 1 -C 6 alkyl and R7O—C 1 -C 6 alkyl; R5 and R6, being the same or different, are independently selected from hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl, aryl, R8R9N—C 2 -C 6 alkyl and R7O—C 2 -C 6 alkyl; R7 is selected from hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl, aryl and R8R9N—C 2 -C 6 alkyl; R8 and R9, being the same or different, are independently selected from hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl and aryl, and R8 and R9, taken together with the nitrogen atom to which they are bonded, form an optionally substituted heterocycloalkyl group; R10 is an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl or aryl; A, B, D and E represent a nitrogen atom, CH, CR2 or CR3, with a maximum of two of A, B, D and E representing a nitrogen atom, CR2 or CR3, wherein: R2 and R3 are independently selected from halogen, trifluoromethyl, nitro, OR7, NR8R9, an optionally further substituted straight or branched C 1 -C 6 alkyl, R8R9N—C 1 -C 6 alkyl and R7O—C 1 -C 6 alkyl, wherein R7, R8 and R9 are as defined above; Ra and Rb are independently hydrogen or methyl, with the proviso that when Ra, Rb, and R1 are hydrogen atoms, then at least one of A, B, D and E is nitrogen; or optical isomers, tautomers or pharmaceutically acceptable salt thereof.