Patent ID: 6906061

Claim:
A method for treatment of cancer, immune disease, autoimmune disease, AIDS, osteoporosis, immature birth, or fertilization and nidation of fertilized egg, comprising administering a pharmaceutically effective amount of a Rho kinase inhibitor to a patient in need thereof, wherein the Rho kinase inhibitor comprises a substituted isoquinolinesulfonamide compound comprising of the formula (II): wherein R 12 represents a hydrogen atom, a chlorine atom or a hydroxyl group; and when R 12 represents a hydrogen atom, Alk represents an ethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, a phenyl group or a benzyl group, R 13 and R 14 are directly bonded with each other, thereby forming a trimethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, a phenyl group or a benzyl group, and R 15 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and when R 12 represents a chlorine atom or a hydroxyl group, Alk represents an alkylene group having 2 to 6 carbon atoms, said group being unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, R 13 and R 14 are not bonded with each other and each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or R 13 and R 14 are directly bonded with each other, thereby forming an ethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms or a trimethylene group unsubstituted or substituted with an alkyl group having 1 to 6 carbon atoms, and R 15 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an amidino group, an isomer thereof and/or a pharmaceutically acceptable acid addition salt thereof.