Patent ID: 6849740

Claim:
A compound having the following formula: wherein: (a) X is (b) R1 is selected from the group consisting of C 3 to about C 5 cycloalkyl, C 1 to about C 2 alkanyl, C 2 to about C 3 linear alkenyl, C 3 to about C 4 branched alkanyl or alkenyl, all such alkyl or cycloalkyl moieties being unsubstituted or substituted with from 1 to about 3 fluoro; and phenyl, unsubstituted or substituted with from 1 to about 3 fluoro, or with one hydroxy in the 4-position; (c) R3 is hydrogen or hydroxy; (d) R5 is selected from the group consisting of hydrogen, hydroxy, amino, halo, C 1 to about C 2 alkanyl, C 2 alkenyl, and methoxy, all such alkyl and methoxy moieties being unsubstituted or substituted with from 1 to about 3 fluoro; (e) R8 is selected from the group consisting of fluoro, chloro and bromo; (f) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C 1 to about C 3 alkanyl; and (g) each R9 is independently selected from the group consisting of hydrogen, C 1 to about C 4 alkanyl, C 2 to about C 6 alkenyl or alkynyl, and a C 3 to about C 6 fused or spirocycle alkyl ring; or one R9 may optionally be selected from the group consisting of hydroxy, C 1 to about C 4 alkoxy, aryl and heteroaryl, all other R9 being hydrogen; all alkyl and aryl portions of R9 moieties being unsubstituted or substituted with one hydroxy or with from 1 to about 3 fluoro; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amid, or imide thereof.