Patent ID: 6977267

Claim:
A compound according to formula (I), its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, hydrate, solvate, or prodrug thereof, in which: L and K, taken independently, are O or S; Ar is aryl or heteroaryl; G is selected from a bond, —O—, —N—, —S—, C 1-4 alkylene, C 1-4 substituted alkylene, bivalent alkoxy, alkylthio, aminoalkyl, sulfonyl, sulfonamidyl, acyl, and alkoxycarbonyl; R 2 is selected from hydrogen, alkyl, substituted alkyl, OR 12 , NR 12 R 13 , C(═O)R 12 , CO 2 R 12 , C(═O)NR 12 R 13 , NR 12 C(═O)R 13 , NR 12 C(═O)OR 13 , S(O) p R 13a , NR 12 SO 2 R 13a , SO 2 NR 12 R 13 , cycloalkyl, heterocyclo, aryl, and heteroaryl; R 4a , R 4b and R 4c are independently selected from hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, nitro, cyano, SR 14 , OR 14 , NR 14 R 15 , NR 14 C(═O)R 15 , CO 2 R 14 , C(═O)R 14 , —C(═O)NR 14 R 15 , aryl, heterocyclo, cycloalkyl, and heteroaryl; R 3 is independently selected from hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, alkenyl, substituted alkenyl, aminoalkyl, alkylthio, C(═O)H, acyl, amide, alkoxycarbonyl, sulfonyl, sulfonamidyl, cycloalkyl, heterocyclo, aryl, and heteroaryl; R 9 is —A 1 —Q—A 2 —R 16 ; A 1 is a bond, C 1-2 alkylene, or C 2-3 alkenylene; Q is a bond, —C(═O)—, —C(═O)NR 17 —, —C(═S)NR 17 —, —SO 2 —, —SO 2 NR 17 —, —CO 2 —, or —NR 17 CO 2 —; A 2 is a bond, C 1-3 alkylene, C 2-3 alkenylene, —C 1-4 alkylene-NR 17 —, —C 1-4 alkylene-NR 17 C(═O)—, —C 1-4 alkylene-S—, —C 1-4 alkylene-SO 2 —, or —C 1-4 alkylene-O—, wherein said A 2 alkylene groups are branched or straight chain and optionally substituted with a group selected from —CO 2 H, —CO 2 (C 1-4 alkyl), —S(C 1-4 alkyl), NH 2 , —NH(C 1-4 alkyl), or —N(C 1-4 alkyl) 2 ; R 12 , R 13 , R 14 and R 15 (i) are selected independently of each other from hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; or (ii) R 12 is taken together with R 13 , and/or R 14 is taken together with R 15 to form a heteroaryl or heterocyclo ring; R 13a is selected from alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclo; R 16 is selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, and heterocyclo; and R 17 is hydrogen or alkyl; and p is 1 or 2.