Patent ID: 7674806

Claim:
Amidines of formula (I) and pharmaceutically acceptable salts thereof, wherein Ar is selected from: 3′-benzoylphenyl, 3′-(4-chloro-benzoyl)-phenyl, 3′-(4-methyl-benzoyl)-phenyl, 3′-acetyl-phenyl, 3′-propionyl-phenyl, 3′-isobutanoyl-phenyl, 4′-trifluoromethanesulfonyloxy-phenyl, 4′-benzenesulfonyloxy-phenyl, 4′-trifluoromethanesulfonylamino-phenyl, 4′-benzenesulfonylamino-phenyl, 4′-benzenesulfonylmethyl-phenyl, 4′-acetoxyphenyl, 4′-propionyloxy-phenyl, 4′-benzoyloxy-phenyl, 4′acetylamino-phenyl, 4′propionylamino-phenyl, 4′-benzoylamino-phenyl; R′ is selected from H, C 1 -C 5 -alkyl, phenyl, C 1 -C 5 -phenyalkyl, C 1 -C 5 -cycloalkyl, C 1 -C 5 -alkenyl, C 1 -C 5 -alkoxy; a residue of formula —(CH 2 )n-NRaRb wherein n is an integer from 0 to 5 and each Ra and Rb, which may be the same or different, are C 1 -C 6 -alkyl, C 1 -C 6 -alkenyl or, alternatively, Ra and Rb, together with the nitrogen atom to which they are bound, form a heterocycle from 3 to 7 members of formula (II), wherein W represents a single bond, O, S, N-Rc, Rc being H, C 1 -C 6 -alkyl or C 1 -C 6 -alkylphenyl, n is an integer from 0 to 4″ R is H, CH 3 , CH 2 CH 3 .