Patent ID: 7569051

Claim:
An implantable apparatus for infusing a plurality of medicating agents to a specific desired location at a tumor site for non-systemic treatment of a tumor, when implanted within a patient's body, comprising: an implantable pouch having one or more collapsible and disintegratable chambers composed of a bioabsorbable material, the chambers being structurally defined by a matrix, each chamber for storing a corresponding one of the plurality of the medicating agents in a macroscopic amount sufficient for tumor treatment, and wherein the chambers are arranged and configured to substantially completely collapse and disintegrate within the patient's body with depletion of the plurality of medicating agents which is selectively dispensed from the chambers; at least one of the plurality of medicating agents are stored in corresponding ones of the plurality of one or more collapsible chambers; at least one implantable piezoelectric pump fabricated in the pouch which forms a skeleton of the pump, the pump being configured to transfer said at least one medicating agent to the patient; an implantable, syngeneic and biodegradable human skin substitute covering the pouch and pump, wherein the biodegradable human skin substitute is arranged and configured to substantially completely collapse and disintegrate within the patient's body with depletion of the plurality of medicating agents which are selectively dispensed from the chambers; and a sensor and control logic on a biodegradable substrate housed within and implanted at the site of implantation of the pouch to monitor biometric measures and indications of the homeostatic response related to at least one of the plurality of medicating agents at the treatment site, where the control logic including a programmable memory controls that at least one piezoelectric pump to modify the state of the tumor in response to measurements from the implanted sensor, and where the control logic controls and selectively adjusts the dose amounts and scheduling with which the medicating agents are delivered in response to selective user commands delivered to the control logic and alterable during a treatment process after implantation.