Patent ID: 7723369

Claim:
A compound of Formula IId: wherein R 1 , R 2 , R 3 , R 4 , and R 5 are independently selected from the group consisting of hydrogen and R b , wherein R 20 is hydrogen, and one or more of R 23 , R 24 , R 25 , R 26 and R 27 are independently selected from the group consisting of: hydrogen, —C 1-10 alkyl, -cycloalkyl, -heterocyclyl, -trifluoroalkyl, -halogen, -carboxy, —CO 2 — 1-10 alkyl —C 1-10 alkylene—CO 2 —C 1-10 alkyl, —C 2-10 alkenylene—CO 2 —C 1-10 alkyl, —C 1-10 alkylene—CO 2 H, —C 1-10 alkenylene—CO 2 H, —O—C 1-10 alkylene—C(O)NH—C 1-10 alkyl, —C(O)—C 1-10 alkyl, —C(O)—NH—C 1-10 alkyl, —O—heterocyclyl, —O—C 1-10 haloalkyl, —O—C 1-10 perhaloalkyl, —O-cycloalkyl, —O-phenyl, —hydroxy, —O—C 1-10 alkylene-cycloalkyl, —O—C 1-10 alkylene-phenyl, —S-heterocyclyl, —S—C 1-10 alkyl, —S—C 1-10 haloalkyl, —S—C 1-10 perhaloalkyl, —S-cycloalkyl, —S-phenyl, —S—C 1-10 alkylene-cycloalkyl, —S—C 1-10 alkylene-phenyl, —C 1-10 alkylene-cycloalkyl, —C 1-10 alkylene-phenyl, -amino —NH(C 1-10 alkyl), —N(C 1-10 alkyl) 2 , —N(C 1-10 alkyl)(C 1-10 alkylene-cycloalkyl), —NHCO 2 —C 1-10 alkyl, —NH(C 1-10 alkylene-cycloalkyl), —S(O) 2 —C 2-10 alkyl, —SO 2 -cycloalkyl, —SO 2 —C 1-10 alkylene-cycloalkyl, —S(O)—C 1-10 alkyl, —S(O)-cycloalkyl, and —S(O)—C 1-10 alkylene-cycloalkyl, wherein alkyl, alkenyl, aryl, heteroaryl, and cycloalkyl groups are optionally substituted 1-4 times with a group independently selected from R C ; G is wherein q is 2, D is C(R 7 )(R 8 ), E is N, and side f is a sincile bond wherein R 7 and R 8 are selected from the group consisting of: hydrogen and C 1-4 alkyl M is hydrogen or a counter ion selected from the group consisting of: Na + , K + , and other pharmaceutically acceptable counter ions; R C is a) -halogen, b) -amino, c) -carboxy, d) —C 1-4 alkyl, e) —O—C 1-4 alkyl, f) -cycloalkyl, g) —O-cycloalkyl, h) -aryl, i) —C 1-4 alkylene-aryl, j) -hydroxy, k) —CF 3 , l) —O-aryl, m) -heteroaryl, n) -heteroaryl-C 1-10 alkyl, o) heterocyclyl, p) —CO 2 —C 1-10 alkyl, or q) —CO 2 —C 1-10 alkyl-aryl, r is 1, or a pharmaceutically acceptable salt thereof.