Patent ID: 7544688

Claim:
A compound of formula IV, or a pharmaceutically acceptable salt thereof in which R is H, —R2, —OR2 or NR1R2, wherein R1 is H, lower alkyl or C 3 to C 10 cycloalkyl, and R2 is lower alkyl or C 3 to C 10 cycloalkyl, and wherein R1 and R2 are independently, optionally substituted by halo, hydroxy, lower alkoxy, CN, NO 2 , or optionally mono- or di-lower alkyl substituted amino; R8′ is optionally substituted aryl-lower alkyl wherein R8′ is optionally substituted by R10 which represents from 1 to 4 substitutents selected from halo, hydroxy, CN, NO 2 , —O—C(O)—, optionally substituted (lower-alkyl, C 3 -C 10 cycloalkyl, lower-alkoxy, lower-alkenyl, lower-alkynyl, optionally mono- or di-lower alkyl-substituted amino or N-heterocyclyl), where N-heterocyclyl denotes a saturated, partially unsaturated or aromatic nitrogen containing heterocyclic moiety attached via a nitrogen atom thereof having from 3 to 8 ring atoms optionally containing a further 1, 2 or 3 heteroatoms selected from N, NR6, O , S, S(O) or S(O) 2 wherein R6 is H or optionally substituted (lower alkyl, carboxy, formyl, acetyl, propionyl, benzoyl, amido, aryl, S(O) or S(O) 2 ), and wherein the N-heterocyclyl is optionally fused in a bicyclic structure with a benzene or pyridine ring, and wherein the N-heterocyclyl is optionally linked in a spiro structure with a 3 to 8 membered cycloalkyl or heterocyclic ring wherein the heterocyclic ring has from 3 to 10 ring members and contains from 1 to 3 heteroatoms selected from N, NR6, O, S, S(O) or S(O) 2 wherein R6 is as defined above; wherein R10 is optionally substituted by R11 which represents from 1 to 4 substituents selected from halo, hydroxy, CN, NO 2 , oxo, optionally substituted (optionally mono- or di-lower alkyl-substituted amino, lower alkyl, optionally-lower alkyl substituted COOH, sulphinyl, sulphonyl, or N-heterocyclyl which is as defined above; wherein R11 is optionally substituted by R12 which represents from 1 to 4 substituents selected from halo, hydroxy, CN, NO 2 , oxo, hydroxy lower alkyl, C 3 -C 10 cycloalkyl, optionally lower alkyl-substituted carboxy, hydroximine, or N-heterocyclyl as defined above, and wherein R9 is H or optionally substituted lower alkyl, and wherein R9 is optionally substituted by halo, hydroxy, oxo, lower alkoxy, CN, NO 2 , or optionally mono- or di-lower alkyl substituted amino.