Patent ID: 8703711

Claim:
A method of reducing neural tissue damage and/or promoting neural tissue repair in a human subject suffering from multiple sclerosis or spinal cord injury, said method comprising administering to said subject an effective amount of an inhibitor of a human nerve injury-induced protein-1 (Ninjurin-1) polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein said inhibitor blocks Ninjurin-1/Ninjurin-1 homotypic interaction and is (a) a peptide consisting of formula II (SEQ ID NO: 14): Xaa 1 -Xaa 2 -Arg-Trp-Xaa 3 -Trp-Arg-Xaa 4 -Xaa 5 -Xaa 6 -Xaa 7 -Xaa 8 (II), wherein Xaa 1 , Xaa 2 , Xaa 4 and Xaa 5 , Xaa 6 , Xaa 7 and Xaa 8 is each independently any amino acid or is absent; Xaa 3 is any amino acid.