Patent ID: 8647670

Claim:
A preparation method for biocompatible rapid-gelating hydrogel, wherein the method comprises: mixing a component A and a component B to form a reactive mixture, wherein the component A is a solution containing biocompatible thiolated macromolecule derivatives, and the component B is a solution containing a biocompatible thiol-reactive crosslinking agent, wherein the biocompatible thiolated macromolecule derivatives are prepared through thiolation of biocompatible macromolecules, wherein the concentration of the biocompatible thiolated macromolecule derivatives in component A is less than 8% w/v, wherein a sum of a concentration of the biocompatible thiolated macromolecule derivatives and a concentration of the biocompatible thiol-reactive crosslinking agent in the reactive mixture is less than 6% w/v, and wherein a pH value of the component A ranges from 3.5-6, wherein a pH value of the component B is more than 8.5; and crosslinking thiol groups of the component A with thiol-reactive functional groups of the component B to form a hydrogel.