Patent ID: 7112606

Claim:
A compound of the formula: wherein R 1 is wherein R 11 is pyrrolyl, optionally substituted with from one to four substituents independently selected from the group consisting of halogen, cyano, nitro, R 14 , OR 13 , SR 13 , N(R 13 ) 2 , NHSO 2 R 14 , NHC(O)R 13 , phenyl, phenyl(C 1 –C 8 )alkyl, and phenyl(C 2 –C 8 )heteroalkyl; wherein each R 13 is independently selected from H, (C 1 –C 8 )alkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl, (C 2 –C 8 )heteroalkyl and halo(C 1 –C 8 )alkyl and each R 14 is independently selected from (C 1 –C 8 )alkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl, (C 2 –C 8 )heteroalkyl and halo(C 1 –C 8 )alkyl; X is a member selected from the group consisting of OH and OR 15 , wherein R 15 is (C 1 –C 8 )alkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl, (C 2 –C 8 )heteroalkyl or halo(C 1 –C 8 )alkyl; Y is H, (C 1 –C 8 )alkyl, (C 3 –C 8 )cycloalkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl or (C 2 –C 8 )heteroalkyl; with the proviso that when Y is a substituted (C 1 –C 8 )alkyl, the substituents are other than fluorine atoms; R 2 is a member selected from the group consisting of H, (C 1 –C 8 )alkyl, (C 2 –C 8 )heteroalkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl, (C 3 –C 8 )cycloalkyl and (C 4 –C 8 )cycloalkyl-alkyl, wherein any alkyl portions of R 2 are optionally substituted with from one to three substituents independently selected from halogen, nitro, cyano, hydroxy, oxo and amino; R 3 is aryl optionally substituted with from one to five substituents independently selected from the group consisting of halogen, cyano, nitro, R 16 , OR 16 , SR 16 , COR 16 , CO 2 R 16 , NHR 16 , N(R 16 ) 2 , CONHR 16 , CON(R 16 ) 2 , NHSO 2 R 16 , NHC(O)R 16 , phenyl, phenyl(C 1 –C 8 )alkyl, and phenyl(C 2 –C 8 )heteroalkyl; wherein each R 16 is independently selected from (C 1 –C 8 )alkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl, (C 2 –C 8 )heteroalkyl and halo(C 1 –C 8 )alkyl; the subscript n is an integer of from 0 to 3; and each R 4 is independently selected from the group consisting of halogen, cyano, nitro, R 17 , OR 17 , SR 17 , COR 17 , CO 2 R 17 , N(R 17 ) 2 and CON(R 17 ) 2 , wherein each R 17 is independently selected from H, (C 1 –C 8 )alkyl, (C 3 –C 8 )alkenyl, (C 3 –C 8 )alkynyl, (C 2 –C 8 )heteroalkyl and halo(C 1 –C 8 )alkyl; or a pharmaceutically acceptable salt thereof.