Patent ID: 8173676

Claim:
A method for the treatment of an inflammatory disease, comprising administering to a host in need thereof an effective amount of a stereoisomer of formula I wherein R 1 and R 2 independently of one another, mean a hydrogen atom, a hydroxy group, a halogen atom, an optionally substituted (C 1 -C 10 )-alkyl group, an optionally substituted (C 1 -C 10 )-alkoxy group, a (C 1 -C 10 )-alkylthio group, a (C 1 -C 5 )-perfluoroalkyl group, a cyano group, a nitro group, or R 1 and R 2 together mean —O—(CH 2 ) p —O—, —O—(CH 2 ) p —CH 2 —, —O—CH═CH—, —(CH 2 ) p+2 —, —NH—(CH 2 ) p+1 , —N(C 1 -C 3 -alkyl)-(CH 2 ) p+1 , or —NH—N═CH—, in which p=1 or 2, and the terminal oxygen atoms and/or carbon atoms and/or nitrogen atoms are linked to directly adjacent ring-carbon atoms, or NR 7 R 8 , in which R 7 and R 8 , independently of one another, mean hydrogen, C 1 -C 5 -alkyl or (CO)—(C 1 -C 5 )-alkyl, R 3 means a hydrogen atom, a hydroxy group, a halogen atom, a cyano group, an optionally substituted (C 1 -C 10 )-alkyl group, a (C 1 -C 10 )-alkoxy group, a (C 1 -C 10 )-alkylthio group, or a (C 1 -C 5 )-perfluoroalkyl group, R 4 means an optionally substituted phthalidyl, indolyl, isoindolyl, dihydroindolyl, dihydroisoindolyl, dihydroisoquinolinyl, dihydroquinolinyl, thiophthalidyl, benzoxazinonyl, phthalazinonyl, quinolinyl, isoquinolinyl, quinolonyl, isoquinolonyl, indazolyl, benzothiazolyl, quinazolinyl, quinoxalinyl, cinnolinyl, phthalazinyl, 1,7- or 1,8-naphthyridinyl, indolonyl, isoindolonyl, dihydroindolonyl, dihydroisoindolonyl, benzimidazole, coumarinyl, isocoumarinyl, pyrazolopyrimidinyl or indolyl group that is linked via any position, R 5 means a partially or completely fluorinated C 1 -C 3 -alkyl group, R 6 means —(C 3 -C 10 )-alkynyl, —(C 1 -C 8 )alkyl(C 3 -C 7 )cycloalkyl, —(C 2 -C 8 )alkenyl(C 3 -C 7 )cycloalkyl, —(C 1 -C 8 )alkylheterocyclyl, —(C 2 -C 8 )-alkenylheterocyclyl, —R 9 , —(C 1 -C 8 )alkyl-R 9 , —(C 2 -C 8 )alkenyl-R 9 , —(C 3 -C 8 )alkynyl-R 9 , —CH 2 —S—(C 1 -C 10 )-alkyl, —CH 2 —S—R 9 , —CH 2 —SO 2 —R 9 , —(CH 2 ) n —R 9 , —CH 2 —SO 2 —(C 1 -C 10 )-alkyl, —(CH 2 ) n —CN —CH 2 —O—(C 1 -C 10 )-alkyl, —(CH 2 ) n —NR 7 R 8 in which R 7 , R 8 have the meaning indicated above or —CH 2 —O—R 9 , in which R 9 means an aryl which may optionally be substituted with 1-3 alkyl, hydroxy, halogen, cyano or C 1 -C 5 -alkoxy groups or a heteroaryl group in which the heteroaryl group may contain 1-3 heteroatoms which may optionally be substituted with 1-3 alkyl, hydroxy, halogen, cyano or C 1 -C 5 -alkoxy groups, n means an integer selected from 1, 2, 3, 4, 5.