Patent ID: 6852719

Claim:
A compound of Formula I a prodrug of said compound or a pharmaceutically acceptable salt of said compound or prodrug; wherein R 1 is a) —(C 1 -C 6 )alkyl optionally substituted with —CF 3 , b) —C≡C—CH 3 , c) —C≡C—Cl, d) —C≡C—CF 3 , e) —CH 2 O(C 1 -C 4 )alkyl optionally substituted with —CF 3 or f) —CF 3 ; R 2 is a) —(C 1 -C 5 )alkyl, b) —(C 2 -C 5 )alkenyl or c)-phenyl optionally substituted with one of the following: —OH, —NR 8 R 9 , —NR 8 —C(O)—(C 1 -C 4 )alkyl, —CN, —Z-het, —O—(C 1 -C 3 )alkyl-C(O)—NR 8 R 9 , —NR 8 —Z—C(O)—NR 8 R 9 , —Z—NR 8 —SO 2 —R 9 , —NR 8 —SO 2 -het, —O—C(O)—(C 1 -C 4 )alkyl or —O—SO 2 —(C 1 -C 4 )alkyl; Z for each occurrence is independently —(C 0 -C 4 )alkyl; R 3 is a) —(C 1 -C 6 )alkyl, b) —Z—NR 4 R 5 or c) —Z-het; R 4 and R 5 are each independently a) hydrogen or b) —(C 1 -C 3 )alkyl; het is an optionally substituted 5-, 6- or 7-membered saturated, partially saturated or unsaturated heterocyclic ring containing from 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and including any bicyclic group in which any of the above heterocyclic rings is fused to a benzene ring or another heterocyclic ring; and optionally substituted with one to three R 6 ; R 6 is a) —(C 1 -C 6 )alkyl optionally substituted with one to three R 7 , b) —Z—NR 8 R 9 or c) —Z—C(O)—NR 8 R 9 ; R 7 for each occurrence is independently a) halo, b) —OH, c) oxo or d) —O(C 1 -C 6 )alkyl; R 8 and R 9 for each occurrence are independently a) —H or b) —(C 1 -C 3 )alkyl; or R 8 and R 9 are taken together with N to form het; n is one to three; provided that: 1) when R 1 is —C≡C—CH 3 , R 2 is phenyl and n is one, then R 3 is other than —CH 2 —N(CH 3 ) 2 , —(CH 2 ) 2 —N(CH 3 ) 2 , —CH 2 -piperidinyl or —(CH 2 ) 2 -morpholinyl; 2) when R 1 is —(CH 2 ) 2 —CH 3 , R 2 is phenyl and n is one, then R 3 is other than -t-butyl or -3,5-dimethyl-4-isoxazolyl.