Patent ID: 7151175

Claim:
An oxadiazoline derivative of the formula R represents a C 1-20 alkyl group, a phenyl group which latter is optionally substituted by 1–3 substituents, wherein the substituents are independently selected from the group consisting of a halo atom, a C 1-2 alkyl group, a C 1-2 alkoxy group, an amino group, a (C 1-4 alkyl)amino group, a di(C 1-4 alkyl)amino group, a (C1–4 alkanoyl)amino group, a 5-membered saturated or unsaturated heterocyclic group containing one or two nitrogen atom(s) or a sulphur atom as the heteroatom and said heterocyclic group is optionally fused with one or more benzene ring(s) and/or one or more heterocyclic group(s) and a 6-membered saturated or unsaturated heterocyclic group containing one or two nitrogen atom(s) or a sulphur atom as the heteroatom and said heterocyclic group is optionally fused with one or more benzene ring(s) and/or one or more heterocyclic group(s); R′ is a hydrogen atom, or R forms together with R′ a C 5-7 cycloalkyl group optionally fused with a benzene ring; R 4 and R 5 represent, independently, a hydrogen atom, a C 1-5 alkyl group, a C 1-5 alkanoyl group or a phenyl group which latter is optionally substituted by 1–3 substituents independently selected from the group consisting of a halo atom, a C 1-2 alkyl group and a C 1-2 alkoxy group, or R 4 and R 5 form together with the adjacent nitrogen atom a 5- or 6-membered saturated or unsaturated heterocyclic group that may contain a further atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulphur atom as the heteroatom, said 5- or 6-membered saturated or unsaturated heterocyclic group optionally being fused with a benzene ring, and the heterocyclic group and/or the benzene ring may bear one or two substituents independently selected from the group consisting of a halo atom, a C 1-2 alkyl group and a C 1-2 alkoxy group; R 3 represents a hydrogen atom, a halo atom, a hydroxy group, a C 1-5 alkoxy group, a C 1-5 alkylthio group, a C 1-20 alkanoyloxy group, a C 3-22 alkenoyloxy group containing one or more double bonds, a methylsulfonyloxy group, a benzenesulfonyloxy group or a toluenesulfonyloxy group; and X is an oxygen atom or a sulfur atom; and N-oxides, geometrical isomers, optical isomers and pharmaceutically suitable acid addition salts and quaternary ammonium derivatives thereof.