Patent ID: 7235551

Claim:
A compound of the formula: wherein R 1 is an optionally substituted aryl or optionally substituted heteroaryl; R 2 is hydrogen, C 1–10 alkyl, C 3–7 cycloalkyl, C 3–7 cycloalkylalkyl, aryl, arylC 1–10 alkyl, heteroaryl, heteroarylC 1–10 alkyl, heterocyclic, or heterocyclylC 1–10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; provided that X is not hydrogen; R 3 is C 1–10 alkyl, C 3–7 cycloalkyl, C 3–7 cycloalkyl C 1–10 alkyl, arylC 1–10 alkyl, heteroarylC 1–10 alkyl, heterocyclylC 1–10 alkyl moiety; and wherein each of these moieties are optionally substituted; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 R 14 , or (CH 2 ) n NR 2 R 4 ; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; R 4 and R 14 are each independently selected from hydrogen, optionally substituted C 1–4 alkyl, optionally substituted aryl or an optionally substituted aryl-C 1–4 alkyl, or R 4 and R 14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR 9 , which ring may be optionally substituted; R 6 is hydrogen, C 1–10 alkyl, C 3–7 cycloalkyl, heterocyclyl, heterocyclyl C 1–10 alkyl, aryl, arylC 1–10 alkyl, heteroaryl or heteroarylC 1–10 alkyl; and wherein each of these moieties, excluding hydrogen, may be optionally substituted; R 9 is hydrogen, C(Z)R 6 , optionally substituted C 1–10 alkyl, optionally substituted aryl or optionally substituted aryl-C 1–4 alkyl; Z is oxygen or sulfur; or pharmaceutically acceptable salt thereof.