Patent ID: 7692011

Claim:
A compound of Formula Ia in which R is O or S; each R 1 is independently halo; each R 8 is independently selected from H, optionally substituted alkyl, optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted aryl; optionally substituted heterocyclyl; CN; halo; CF 3 ; SO 3 H; OR 2 , SR 7 , SOR 2 , SO 2 R 2 , NR 2 R 3 , (CH 2 ) n NR 2 R 3 , HCNOR 2 , HCNNR 2 R 3 , CONR 2 R 3 , CSNR 2 R 3 , NCOR 2 , NCSR 2 , COR 2 , CO 2 R 2 , CSR 2 and SO 2 NR 2 R 3 , in which R 2 and R 3 are independently selected from H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted heterocyclyl, and n is an integer of 1 to 10; R 7 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heterocyclyl; n is an integer of 1 to 10 and m is 1 or 2; or pharmaceutically acceptable salts thereof or tautomers of compounds of Formula Ia, wherein aryl is a 5 or 6-membered aryl group; heterocyclyl is a saturated or unsaturated 3 to 6-membered heterocyclyl containing at least one heteroatom selected from N, O and S, and the optional substituent is C 1-6 alkyl, CF 3 , F, Cl, I, cyano, C 1-6 alkoxy, aryl, heterocyclyl, amino or C 1-6 alkylamino, with the provisos that: (1) when R is O, m is 2 and R 1 is at position 3, then R 1 at position 2 is not (2) R 1 is located at position 5 or 7 or both positions 5 and 7 of the ring.