Patent ID: RE39862

Claim:
Unsaturated 14 , 15 -cyclopranoandrostanes 14 , 15 -cyclopropanoandrostanes of the formula (I): wherein R 1 is represents a hydrogen atom, a hydroxy group, a C 1-10 -alkyl group , a C 1-10 -alkyloxy group , a C 1-15 acyloxy group , a C 4-15 -aryloxy group , a C 7-15 -aralkyloxy group , or a C 7-15 -alkylaryloxy group; R 2 represents a hydrogen atom, a hydroxy group, a C 1-10 alkyl group, a C 1-10 acyl group, a C 1-10 acyloxy group, a C 6-15 aryl group, a C 7-15 aralkyl group, a C 7-15 alkylaryl group, a —(CH 2 ) n CH 2 Y group in which n=0, 1 or 2 and Y represents a halogen atom or a pseudohalogen , a cyano group, an azido group, a cyanato group, or a thiocyanato group ; a —(CH 2 ) m CH═CH(CH 2 ) p R 6 group in which m=0, 1, 2 , or 3 and p=0, 1 , or 2 and R 6 represents a hydrogen atom, a C 1-10 -alkyl group, a C 6-15 aryl group, a C 7-15 aralkyl group, a C 7-15 alkylaryl group, a hydroxyl group, a C 1-10 alkyloxy group , or a C 1-10 acyloxy group; a —(CH 2 ) o C≡CR 7 group in which o=0, 1 , or 2 and R 7 represents a hydrogen atom, a halogen atom, a C 1-10 alkyl group, a C 6-15 aryl group, a C 7-15 aralkyl group, a C 7-15 alkylaryl group , or a C 1-10 acyl group; or R 1 and R 2 together represent a keto group, a methylene group, a difluoromethylene group or, with inclusion of C-17, a spirooxirane or a 2,2-dimethyl-1,3-dioxolane; in which optionally a 1 , 2 double bond is present; R 3 represents a hydrogen atom , or a α-C 1-10 alkyl group , or a β-C 1-10 alkyl group; R 4 represents a halogen atom, a pseudohalogen cyano group , an azido group, a thiocyanato group, a cyanato group, a hydroxy group , or a perfluoroalkyl group; R 5 represents a C 1-4 alkyl group; in which an α-cyclopropane group or a β-cyclopropane group is present between C-14 and C-15; in which optionally a 1 , 2 -double bond is present and with the proviso that, if said 1,2-double bond is present, then R 4 can be represent a hydrogen atom in addition to said halogen atom, said pseudohalogen cyano group, said azido group, said thiocyanato group, said hydroxy group , or said perfluoroalkyl group; or pharmaceutically tolerated salts thereof.