Patent ID: 8604080

Claim:
A method for treating a subject having at least one obsessive-compulsive spectrum disorder, the method comprising administering to the subject a therapeutic amount of a composition, comprising: (i) an agonist of at least one N-methyl-D-aspartate receptor (NMDAR) having the structure: wherein R 1 or R 2 is —H, —CH 3 , —C 1 -C 6 alkyl, —C 2 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, -aryl, —(C 1 -C 6 alkyl)-aryl, —C 3 -C 6 alkyl, C 2 -C 4 alkyl, —OR 5 , —CN, —CF 3 , —OCF 3 , —NO 2 , —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , —NHC(O)—(C 1 -C 6 alkyl), —NHC(O)NH(C 1 -C 6 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6 alkyl), —SO 2 N(C 1 -C 6 alkyl) 2 , —NHSO(C 1 -C 6 alkyl), —C(O)O—(C 1 -C 6 alkyl), —C(O)NH(C 1 -C 6 alkyl), or —C(O)N(C 1 -C 6 alkyl) 2 ; R 3 or R 4 is —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, -aryl, —CH 2 —O—R 5 , —CH 2 —R 5 , —(C 1 -C 6 alkyl)- aryl, -5 or 6-membered aromatic or non-aromatic heterocycle or —(C 1 -C 6 alkyl)-(5 or 6-membered aromatic or non-aromatic heterocycle), wherein the —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, -aryl, —(C 1 -C 6 alkyl)-aryl, -5 or 6-membered aromatic or non-aromatic heterocycle or —(C 1 -C 6 alkyl)-(5 or 6-membered aromatic or non-aromatic heterocycle) group is unsubstituted or substituted with at least one of the following groups: -halo, —OR 5 , —CN, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —CF 3 , —OCF 3 , —NO 2 , —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , —NHC(O)—(C 1 -C 6 alkyl), —NHC(O)NH(C 1 -C 6 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6 alkyl), —SO 2 N(C 1 -C 6 alkyl) 2 , —NHSO(C 1 -C 6 alkyl), —C(O)O—(C 1 -C 6 alkyl), —C(O)NH(C 1 -C 6 alkyl), or —C(O)N(C 1 -C 6 alkyl) 2 ; Y is -halo, —OR 5 , —CN, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, -aryl, —(C 1 -C 6 —CF 3 , —OCF 3 , —NO 2 , —NH 2 , —NHC 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , or —NHNH—R 5 ; and R 5 =R 1 or R 3 ; and (ii) a carrier; wherein the therapeutic amount is effective to reduce at least one obsessive-compulsive spectrum disorder (OCSD) behavior by the subject relative to a control subject who has not been treated with the composition, and the obsessive-compulsive spectrum disorder (OCSD) behavior is selected from the group consisting of a social discomfort behavior, a mirror intolerance behavior, a perseverative behavior, a line-crossing obsession, a prayer ritual, a hand washing ritual, or a combination thereof.