Patent ID: 8394798

Claim:
A compound having the structure of Formula I: and pharmaceutically acceptable salts, and hydrates thereof; wherein: R 1 , if present, is selected from the group consisting of: C 1-8 alkyl, C 1-8 haloalkyl, C 3-8 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, halogen, —NO 2 , —CN, —OR a , —SR a and —NR a R b ; wherein R a and R b are each independently selected from the group consisting of: hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, aryl-C 0-6 alkyl and heteroaryl-C 0-6 alkyl, or when R a and R b are attached to the same nitrogen, R a and R b can be optionally combined to form a 5- to 7-member heterocycloalkyl ring having from 1-3 heteroatoms selected from the group consisting of N, O and S; R 2 , if present, is selected from the group consisting of: C 1-8 alkyl, C 1-8 haloalkyl, C 3-8 cycloalkyl, —NO 2 , —CN, halogen, —C(O)R d , —C(O)OR d , —C(O)NR d R e , —NR d R e , —S(O) 2 NR d R e , OR d , SR d , and —NR d C(O)R f ; wherein R d and R e are each independently selected from the group consisting of: hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, aryl—C 0-6 alkyl and heteroaryl-C 0-6 alkyl, or when R d and R e are attached to the same nitrogen, R d and R e can be optionally combined to form a 5- to 7-member heterocycloalkyl ring having from 1-3 heteroatoms selected from the group consisting of N, O and S; R f is selected from the group consisting of: C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkenyl, C 0-6 alkyl-aryl and C 0-6 alkyl-heteroaryl; m and n are each independently an integer from 0 to 4; R 3 is a member selected from the group consisting of: C 1-8 alkyl, C 1-8 haloalkyl, C 3-8 cycloalkyl, C 1-8 acyl, —SO 2 —C 1-8 alkyl, aryl-C 0-4 alkyl and heteroaryl-C 0-4 alkyl; R 4 , if present, is selected from the group consisting of: C 1-8 alkyl, halogen, —NO 2 and —CN; and o is an integer from 0 to 1.