Patent ID: 7358276

Claim:
A compound of formula AA-II, or a pharmaceutically acceptable salt thereof: wherein X is —CA 1 NR 5 R 6 or —CA 1 —R 8 ; A 1 is oxygen, sulfur or —NR 9 ; Q 1 together with the oxygen to which it is attached is a leaving group; R 1 is hydrogen, alkyl, aryl or —CH 2 —R 1a wherein R 1a is aryl, halogen, hydroxy, amino, nitro or cyano; R 3 is hydrogen, halogen, thiol, nitro, nitrooxy, cyano, azido, carboxy, amido, sulfonic acid, sulfonamide, alkyl, alkcenyl, alkynyl, ester, ether, aryl, tetrazolyl, thiazolyl, thienyl, furyl, pyrrolyl, pyridinyl, alkynyloxy, acyloxy, oxyester, oxyamido, alkylsulfonyloxy, alkylsulfinyloxy, arylsulfonyloxy, arylsulfinyloxy, aryloxy, aralkoxy, alkylthio, alkenylthio, alkynylthio, arylthio, formyl, acetyl, propionyl, isobutyryl, valeryl, lauroyl, heptanedioyl, cyclohexanecarbonyl, crotonoyl, furmaroyl, acyloyl, benzoyl, naphtoyl, 4-carboxybutanoyl, oxalyl, ethoxalyl, cysteinyl, oxamoyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, arylsulfonyl, alkylsulfinyl, alkenylsulfinyl, alkynylsulfinyl or arylsulfinyl; R 3a is hydrogen, halogen, alkyl, alkenyl, alkynyl or aryl; R 5 , R 6 and R 9 are the same or different and each is independently hydrogen, hydroxy, alkyl, aryl, alkoxy, alkenyloxy, alkynyloxy, acyloxy, oxyester, oxyamido, alkylsulfonyloxy, alkylsulfinyloxy, arylsulfonyloxy, arylsulfinyloxy, aryloxy or arylakoxy; and R 8 is hydrogen, hydroxy, thiol, halogen, alkyl, aryl, alkylthio, alkenylthio or alkynylthio; with the provisos that at least one of R 3 and R 3a is other than hydrogen; and that when the compound is a mixture of all possible stereoisomers, X is —CONR 5 R 6 and R 1 is hydrogen, methyl, ethyl or propyl then R 3 and R 3a substitution on the pyrrolidine ring is other than mono-, di-methyl or mono-ethyl; and that when R 1 and R 3a are both hydrogen and X is —CONR 5 R 6 then R 3 is different from carboxy, ester, amido, substituted oxo-pyrrolidine, alkynyloxy, acyloxy, oxyester, oxyamido, alkylsulfonyloxy, alkylsulfinyloxy, arylsulfonyloxy, arylsulfinyloxy, aryloxy, aralkoxy, methyl, naphtyl, phenyl optionally substituted by oxy derivatives or in the para position by an halogen atom.