Patent ID: 7109235

Claim:
A method of treating an individual suffering from a cancer wherein stabilization of microtubules provides a benefit, comprising administration of therapeutically effective amount of a compound to the individual, wherein the cancer is a breast cancer, an ovarian cancer, a lung cancer, a myeloid leukemia, or a skin cancer, and wherein the compound has a general formula wherein R 1 is selected from the group consisting of hydro, OR a , and C 1-3 alkyl; R 2 is selected from the group consisting of a saturated or unsaturated monocyclic 3–7 membered heterocyclic ring having 1–3 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, C 3-7 cycloalkyl, C 3-7 cycloalkenyl, and a monocyclic or bicyclic ring system containing five to ten atoms and one or two aromatic rings and containing one to four heteroatoms selected from nitrogen, oxygen, and sulfur in the aromatic ring; R 4 is C 1-4 alkyl; X and Y, independently, are selected from the group consisting of 0 and NR a ; R a is selected from the group consisting of hydro and C 1-4 alkyl; n is 0 or 1; or a pharmaceutically acceptable salt thereof.