Patent ID: 7173009

Claim:
A method of treating a disorder selected from the group consisting of pneumonia, bronchitis, meconim aspiration syndrome, cystic fibrosis, Infant Respiratory Distress Syndrome (IRDS) and Adult Respiratory Distress Syndrome (ARDS) in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a surfactant protein C (SP-C) having the amino acid sequence SEQ ID NO: 3 of the formula I 0â€ƒâ€ƒâ€ƒâ€ƒ1â€ƒâ€ƒâ€ƒ2â€ƒâ€ƒâ€ƒ3â€ƒâ€ƒâ€ƒ4â€ƒâ€ƒâ€ƒ5â€ƒâ€ƒâ€ƒ6â€ƒâ€ƒâ€ƒ7â€ƒâ€ƒâ€ƒ8â€ƒâ€ƒâ€ƒ9â€ƒâ€ƒ10 (A)â€ƒâ€ƒGlyâ€ƒIleâ€ƒProâ€ƒâ€ƒâ€ƒBâ€ƒâ€ƒâ€ƒBâ€ƒProâ€ƒValâ€ƒHisâ€ƒLeuâ€ƒLys 11â€ƒâ€ƒ12â€ƒâ€ƒ13â€ƒâ€ƒ14â€ƒâ€ƒ15â€ƒâ€ƒ16â€ƒâ€ƒ17â€ƒâ€ƒ18â€ƒâ€ƒ19â€ƒâ€ƒ20 Argâ€ƒLeuâ€ƒLeuâ€ƒIleâ€ƒValâ€ƒValâ€ƒValâ€ƒValâ€ƒValâ€ƒValâ€ƒ(I), 21â€ƒâ€ƒ22â€ƒâ€ƒ23â€ƒâ€ƒ24â€ƒâ€ƒ25â€ƒâ€ƒ26â€ƒâ€ƒ27â€ƒâ€ƒ28â€ƒâ€ƒ29â€ƒâ€ƒ30 Leuâ€ƒIleâ€ƒValâ€ƒValâ€ƒValâ€ƒIleâ€ƒValâ€ƒGlyâ€ƒAlaâ€ƒLeu 31â€ƒâ€ƒ32â€ƒâ€ƒ33â€ƒâ€ƒ34 Leuâ€ƒâ€ƒâ€ƒCâ€ƒGlyâ€ƒLeu in which A is absent or Phe, B is Phe or Trp and C is Ile, Leu or Ser, wherein the amino acid at the carboxy terminus of the surfactant protein is esterified with an alcohol having 1â€“4 carbon atoms, and wherein the esterified surfactant protein C is isolated and purified, or a pharmacologically acceptable salt thereof.