Patent ID: 7371568

Claim:
An isolated, recombinant human chromosome comprising: (i) the SC20 chromosome fragment (Accession Number FERM BP-7583), which comprises the human chromosome #14 centromere; (ii) two telomere sequences; (iii) at least one recognition sequence for a site-directed recombination enzyme; (iv) at least two fragments from different human chromosomes, wherein each fragment comprises an antibody gene, wherein one of the fragments comprises a human chromosome #14 fragment which comprises the human antibody heavy-chain gene and wherein a second chromosome fragment comprises either a human chromosome #2 fragment which comprises the human antibody light-chain kappa, or a human chromosome #22 fragment which comprises the human antibody light-chain lambda gene; and (v) a marker gene, wherein the at least one recognition sequence of (iii) for the site-directed recombination enzyme is located between the chromosome fragments of (iv).