Patent ID: 8461133

Claim:
A process for the preparation of an aqueous soluble inclusion compound comprising one or more active substances included in one or more host molecules, the active substance or substances not being very soluble in an aqueous medium, wherein it comprises the following successive steps: a. bringing one or more electrically uncharged active substances into contact with one or more host molecules, b. carrying out a step of molecular diffusion by bringing a dense pressurized fluid into contact, in static mode, with the mixture obtained in step (a) in the presence of water as a diffusion agent in an amount of between 1 and 50% by weight with respect to the total weight, c. depressurizing and recovering the active substance/host molecule molecular complex thus formed, d. carrying out a step which consists of adding to and mixing with the active substance/host molecule molecular complex ma agent for interaction with the complex under atmospheric pressure in a semi-solid medium wherein said agent fbr interaction with the complex is an acid or a base, e. recovering the aqueous soluble inclusion compound thus formed, wherein the aqueous soluble inclusion compound is in a salt form comprising said active substance, host molecule, and agent for interaction, and wherein said host molecule is selected from the group consisting of cyclodextrins and mixtures thereof and said dense pressurized fluid is carbon dioxide.