Patent ID: 7491746

Claim:
A method for the treatment of a cellular proliferative disease comprising administering to a subject in need thereof a pharmaceutical composition comprising a compound of Formula I: or a pharmaceutically acceptable salt, hydrate, or mixture thereof, wherein: R 1 is chosen from optionally substituted aryl-C 1 -C 4 alkyl and optionally substituted heteroaryl-C 1 -C 4 alkyl; R 2 and R 2′ are independently chosen from hydrogen, optionally substituted alkyl-, optionally substituted alkoxy, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, and optionally substituted heteroaralkyl; R 12 is —N(R 4 )(COR 3 ); R 3 is optionally substituted aryl; R 4 is R 16 -alkylene- wherein R 16 is hydroxyl, di(C 1 -C 4 alkyl)amino-, (C 1 -C 4 alkyl)amino-, amino, C 1 -C 4 -alkoxy, or N-heterocyclyl; and R 5 , R 6 , R 7 and R 8 are independently chosen from hydrogen, acyl, optionally substituted alkyl, optionally substituted alkoxy, halogen, hydroxyl, nitro, cyano, dialkylamino, alkylsulfonyl-, alkylsulfonamido-, alkylthio-, carboxyalkyl-, carboxamido-, aminocarbonyl-, optionally substituted aryl and optionally substituted heteroaryl.