Patent ID: 8374794

Claim:
A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of: (a) providing a molecular model of at least a portion of a cycloheximide binding site of a large subunit of a ribosome created from (i) the atomic co-ordinates for the Haloarcula marismortui large ribosomal subunit found on Disk 1 under file name cycloheximide.pdb, or (ii) atomic co-ordinates derived by homology modeling, molecular replacement, or both homology modeling and molecular replacement using the Haloarcula marismortui atomic co-ordinates found on Disk 1 under file name cycloheximide.pdb, wherein the at least a portion of a cycloheximide binding site is formed by at least 3 amino acid and/or nucleotide residues set forth in Table 1A or Table 1B; (b) using the molecular model to identify a candidate molecule that binds to at least a portion of the cycloheximide binding site of the molecular model; and (c) producing the candidate molecule identified in step (b).