Patent ID: 7964591

Claim:
A method of treating a skin disorder mediated by stearoyl-CoA desaturase (SCD) in a mammal, wherein the method comprises administering to the mammal in need thereof a therapeutically effective amount of a compound of formula (I): wherein: x and y are each independently 1, 2 or 3, provided that x and y are not both 1; W is —C(O)N(R 1 )—, —C(O)N[C(O)R 1a ]—, —N(R 1 )C(O)N(R 1 )— or —N(R 1 )C(O)—; V is —C(O)—, —C(S)—, or —C(R 10 )H; each R 1 is independently selected from the group consisting of hydrogen; C 1 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of halo, methyl or trifluoromethyl; and C 2 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of methoxy and hydroxyl; R 1a is selected from the group consisting of hydrogen, C 1 -C 6 alkyl and cycloalkyl; R 2 is selected from the group consisting of C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl, C 1 -C 12 alkoxy, C 2 -C 12 alkoxyalkyl, C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, aryl, C 7 -C 12 aralkyl, C 3 -C 12 heterocyclyl, C 3 -C 12 heterocyclylalkyl, C 1 -C 12 heteroaryl, and C 3 -C 12 heteroarylalkyl; R 3 is selected from the group consisting of C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl, C 1 -C 12 alkoxy, C 2 -C 12 alkoxyalkyl, C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, aryl, C 7 -C 12 aralkyl, C 3 -C 12 heterocyclyl, C 3 -C 12 heterocyclylalkyl, C 1 -C 12 heteroaryl and C 3 -C 12 heteroarylalkyl; R 4 and R 5 are each independently selected from hydrogen, fluoro, chloro, methyl, methoxy, trifluoromethyl, cyano, nitro or —N(R 12 ) 2 ; R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 , and R 9a are each independently selected from hydrogen or C 1 -C 3 alkyl; or R 6 and R 6a together, or R 7 and R 7a together, or R 8 and R 8a together or R 9 and R 9a together are an oxo group, provided that when V is —C(O)—, R 7 and R 7a together, or R 8 and R 8a together, do not form an oxo group, while the remaining R 7 , R 7a , R 8 , R 8a , R 9 , R 9a , R 10 , and R 10a are each independently selected from hydrogen or C 1 -C 3 alkyl; one of R 6 , R 6a , R 7 , and R 7a together with one of R 8 , R 8a , R 9 and R 9a form an alkylene bridge, while the remaining R 7 , R 7a a, R 8 , R 8a , R 9 , R 9a , R 10 , and R 10a are each independently selected from hydrogen or C 1 -C 3 alkyl; R 10 is hydrogen or C 1 -C 3 alkyl; and each R 12 is independently selected from hydrogen or C 1 -C 6 alkyl; a stereoisomer, enantiomer or tautomer thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof, wherein the skin disorder is selected from the group consisting of acne, rosacea, seborrheic skin, and any combination of these.