Patent ID: 6875765

Claim:
A compound represented by generalized structure 1: wherein Z represents carboxylate, alkoxycarbonyl, or aryloxycarbonyl; G represents formyl or —CN; or Z, G, and R, together with the carbon atoms in the generalized structure 1 to which they are attached, form a radical of the formula: J represents optionally substituted benzimidazolyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, adamantyl, azabenzimidazolyl, or indazolyl; X represents (C(R) 2 ) f , or (C(R) 2 ) f (C(R) 2 ); R represents independently for each occurrence H or alkyl; R 2 is absent or present 1, 2, or 3 times; R 2 represents independently for each occurrence alkyl, alkenyl, alkynyl, halogen, formyl, acyl, carboxylate, alkoxycarbonyl, aryloxycarbonyl, carboxamido, alkylamino, acylamino, hydroxyl, alkoxyl, acyloxy, hydroxyalkyl, alkoxyalkyl, aminoalkyl, (alkylamino)alkyl, alkylthio, mercapto, mercaptoalkyl, (alkylthio)alkyl, carbamoyl, ureido, thioureido, sulfonyl, sulfonate, sulfonamido, sulfonylamino, or sulfonyloxy; R 3 represents hydrogen, alkoxyl, amino, alkylamino, dialkylamino, (aminoalkyl)amino, ((alkylamino)alkyl)amino, ((dialkylamino)alkyl)amino, acylamino, (aminoacyl)amino, ((alkylamino)acyl)amino, ((dialkylamino)acyl)amino, (heterocyclyl)acylamino, carboxamido, (aminoalkyl)carboxamido, (alkylamino)alkyl)carboxamido, (dialkylamino)alkyl)carboxamido, sulfonylamino, urea, thiourea, —C(O)N(R)N(R) 2 , —C(O)N(R)C(R) 2 CO 2 H, or —C(O)N(R)C(R) 2 C(O)N(R) 2 ; f represents 1, 2, or 3; and the stereochemical configuration at any stereocenter of a compound represented by 1 may be R, S, or a mixture of these configurations, and the pharmaceutically acceptable salts, thereof.