Patent ID: 8188048

Claim:
A method of producing analgesia in a subject comprising administering a synergistic combination of an effective amount of a selective inhibitor of the neuronal norepinephrine transporter and an effective amount of an analgesic agent, wherein administration of said synergistic combination produces analgesia in said subject; wherein the selective inhibitor of the neuronal norepinephrine transporter comprises the following sequence of amino acids: (SEQ ID NO: 5) Xaa0 Xaa1 Xaa2 Xaa3 Xaa4 Cys 1 Cys 2 Gly Tyr Lys Leu Cys 3 Xaa8 Xaa9 Cys 4 , where Xaa0 is selected from Tyr, Trp, hPhe and a deletion; Xaa1 is a deletion; Xaa2 is selected from Arg, Ala, Asn, Lys, Phe, BHK, Orn, DArg, Nle, DLys, DMK, DAsn, Thr, ABZ, Nap, Cit, Val, Tyr, Trp, pGlu, DpGlu, Gln, Thr, Glu, Asp and a deletion; Xaa3 is selected from Gly, Asp, and Ala; Xaa4 is selected from Val, Leu, Nle, Ile, and Ala; Xaa8 is selected from His, Arg, Trp, Nal, and a deletion; Xaa9 is selected from Hyp, Pro, Ala, Tic, Pip, MeY, DMD, Phe, THZ, Glu, Nle, Tyr, and a deletion; and wherein Cys 1 is connected to Cys 4 and Cys 2 is connected to Cys 3 by disulfide bonds.