Patent ID: 8124118

Claim:
An injectable pharmaceutical composition comprising: i) one or more biodegradable hydrating ceramics; ii) one or more expandable agents, wherein the expandable agent is present in the composition at a concentration of at least about 0.1% w/w to about 2.5% w/w; iii) a sorbed aqueous medium wherein the sorbed aqueous medium is present in the composition at a concentration of at the most about 30% w/w to about 60% w/w of the total composition; and iv) one or more therapeutically and/or diagnostically active substances, which is an androgen, an anti-androgen, an oestrogen, an anti-oestrogen, a gestagen, an anti-gestagen, an oligonucleotide, a progestagen, a gonadotropin-releasing hormone, a gonadotropin inhibitor, an adrenal and/or prostate enzyme inhibitor, a membrane efflux and/or membrane transport protein, an immune system modulator, an angiogenesis inhibitor, or combinations thereof, which in solid form has a ruptured structure, and wherein the composition solidifies within 20 minutes or less when stored at 37° C.