Patent ID: 7666991

Claim:
A delivery construct, comprising an isolated carrier construct non-covalently bound to an isolated antibody, wherein said carrier construct comprises: a) a receptor-binding domain, wherein said receptor-binding domain (i) binds to a cell-surface receptor that is selected from the group consisting of α2-macroglobulin receptor, epidermal growth factor receptor, transferrin receptor, chemokine receptor, CD25, CD11B, CD11C, CD80, CD86, TNFα receptor, TOLL receptor, M-CSF receptor, GM-CSF receptor, scavenger receptor, and VEGF receptor, or (ii) is selected from the group consisting of a receptor-binding domain from Pseudomonas exotoxin A; cholera toxin; botulinum toxin; diptheria toxin; shiga toxin; shiga-like toxin; TGF α; EGF; IGF-I; IGF-II; IGF-III; IL-1; IL-2; IL-3; IL-6; MIP-1a; MIP-1b; MCAF; and IL-8, b) a transcytosis domain, and c) an antibody-binding domain to which the antibody non-covalently binds, wherein said antibody-binding domain is an Fc binding domain.