Patent ID: 8303974

Claim:
A method of treating a cerebral vasospasm in a human subject, the method comprising the steps: a) providing a flowable pharmaceutical composition for sustained release comprising a therapeutic amount of a therapeutic agent and a carrier, wherein the therapeutic agent comprises an L-type voltage-gated calcium channel inhibitor and the carrier comprises a plurality of microparticles, wherein the L-type voltage-gated calcium channel inhibitor is dispersed throughout each microparticle; b) administering the pharmaceutical composition to the human subject locally via surgical injection into the subarachnoicl space in a cistern closest to a cerebral artery at risk for vasospasm, such that the composition flows around the cerebral artery without entering the systemic circulation in an amount to cause unwanted side effects; wherein the pharmaceutical composition produces a localized pharmacologic effect: and wherein the therapeutic amount is effective to treat the cerebral vasospasm.