Patent ID: 8017579

Claim:
An isolated polypeptide or analogue thereof, comprising a tandem repeat of apolipoprotein B, wherein the isolated polypeptide or analogue thereof is according to formula I: abcRKRxyza′b′c′RKRx′y′z′ (I) wherein a and a′ are each independently selected from the group consisting of a positively charged residue, which is Arginine (R), Lysine (K) or Histidine (H), Leucine (L), Tryptophan (W), and deleted; b and b′ are each independently selected from the group consisting of Leucine (L), Arginine (R), Lysine (K), and deleted; c and c′ are each independently selected from the group consisting of Threonine (T), Tryptophan (W), and a positively charged residue, which is Arginine (R), Lysine (K) or Histidine (H); x and x′ are each independently selected from the group consisting of Glycine (G), Tryptophan (W), Leucine (L), and a positively charged residue, which is Arginine (R), Lysine (K) or Histidine (H); y and y′ are each independently selected from the group consisting of Leucine (L), a positively charged residue, which is Arginine (R), Lysine (K) or Histidine (H), and deleted; and z and z′ are each independently selected from the group consisting of a positively charged residue, which is Arginine (R), Lysine (K) or Histidine (H), Leucine, and deleted, or a truncation thereof comprising the tandem repeat of apolipoprotein B, characterized in that the tandem repeat or truncation thereof comprising the tandem repeat of apolipoprotein B is obtained from a heparin sulphate proteoglycan (HSPG) receptor binding region of apolipoprotein B.