Patent ID: 7541034

Claim:
A method for inhibiting the growth of a human hairy-cell leukemia cell that expresses a CD22 molecule on the surface of the cell, said method comprising: contacting said human hairy-cell leukemia cell in vivo with an effective amount of a recombinant immunoconjugate comprising a Pseudomonas exotoxin PE38 covalently linked at its amino terminus to an RFB4 disulfide-stabilized Fv (dsFv) having a variable heavy chain (V H ) comprising SEQ ID NO:2 in which a Cys residue is substituted for Arg at position 44; and a variable light chain (V L ) comprising SEQ ID NO:4 in which a Cys residue is substituted for Gly at position 100, thereby inhibiting the growth of the human hairy-cell leukemia cell.