Patent ID: 6887869

Claim:
A compound of the formula: corresponding to sub-formulae: wherein R 1 is selected from the group consisting of hydrogen, â€”SR 4 and â€”NR 4 R 5 ; R 2 is â€”SR 6 or â€”NR 6 R 7 ; R 3 is selected from the group consisting of OH, â€”O(CO)R 14 , â€”OSiR 15 R 16 R 17 , â€”O(CO)OR 18 and â€”O(CO)NHR 18 ; R 4 and R 6 are individually selected from the group consisting of, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, aryl and aralkyl optionally substituted on the aryl by at least one member of the group consisting of alkyl, hydroxy and alkoxy, R 5 and R 7 are individually selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, aryl and aralkyl optionally substituted on the aryl by at least one member of the group consisting of alkyl, hydroxy and alkoxy or R 4 and R 5 form together with the nitrogen atom which carries them a heterocycle with 5 to 7 ring members the additional member being selected from the group consisting of â€”CR 8 R 9 â€”, â€”NR 10 â€”, â€”Oâ€” and â€”Sâ€”, it being understood that there can only be one member chosen from â€”Oâ€” or â€”Sâ€” in said heterocycle, or R 6 and R 7 form together with the nitrogen atom which carries them a heterocycle with 5 to 7 ring members, the additional member being selected from the group consisting of â€”CR 11 R 12 â€”, â€”NR 13 â€”, â€”Oâ€” and â€”Sâ€” it being understood however that there can only be one member chosen from â€”Oâ€” or â€”Sâ€” in said heterocycle, R 8 , R 10 , R 11 and R 13 are individually hydrogen, alkyl, alkoxycarbonyl and aralkyl, R 9 and R 12 are individually hydrogen or alkyl or each of R 9 and R 12 being able to form respectively together with R 8 and R 11 â€”Oâ€”(CH 2 ) 2 â€”Oâ€” attached on either side to the carbon atom which carries it, such a radical only being present once at most per NR 4 R 5 or NR 6 R 7 R 14 is selected from the group consisting of alkyl, cycloalkyl, adamantyl, aryl, heteroaryl, aralkyl and heteroaralkyl optionally substituted on the aryl or heteroaryl by at least one member of the group consisting of halogen, alkyl, haloalkyl, nitro, hydroxy, alkoxy, alkylthio and phenyl; or R 14 is such that R 14 â€”COOH is a natural amino acid or the optical enantiomer of such an amino acid; R 15 , R 16 and R 17 are individually alkyl, or phenyl; R 18 is selected from the group consisting of alkyl, cycloalkyl, adamantyl, aryl, heteroaryl, aralkyl and heteroaralkyl optionally substituted on the aryl or heteroaryl by at least one member of the group consisting of halogen, alkyl, haloalkyl, nitro, hydroxy, alkoxy, alkylthio and phenyl; it being understood however that when the compounds correspond to sub-formula (I) 2 , then R 1 is not hydrogen; or a pharmaceutically acceptable salt thereof.