Patent ID: 7442710

Claim:
A compound of formula IA-4 wherein R 1 is aryl, a cyclic amine selected from the group consisting of pyrrol-1-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1-oxo-thiomorpholin-4-yl and 1, 1-dioxo-thiomorpholin-4-yl, OR 11 , SR 11 , or N(R 12 ) 2 ; R 11 is lower alkyl, lower alkyl substituted by halogen, or —(CH 2 ) n -cycloalkyl; each R 12 is independently hydrogen or lower alkyl; R 2 is NO 2 , CN or S(O) 2 -lower alkyl; R 3 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, or lower alkoxy; R 4 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, non cyclic amine, lower alkoxy, or benzyloxy optionally substituted by halogen; R 5 and R 6 are each independently hydrogen, halogen, lower alkyl, lower alkoxy, aryl or form together the keto group ═O; R′ is hydrogen, halogen, lower alkyl, lower alkoxy, or benzyloxy optionally substituted by halogen; R″ is hydrogen; alkyl substituted by halogen; halogen; nitro; lower alkoxy; cyano; COO-lower alkyl; benzyloxy optionally substituted by halogen; or S(O) 2 -cyclic amine, wherein the cyclic amine is selected from the group consisting of pyrrol-1-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1-oxo-thiomorpholin-4-yl and 1,1-dioxo-thiomorpholin-4-yl; or R 3 and R″ or R 4 and R′ or R″ and R 4 are together with the carbon atom to which they are attached —O—(CH 2 ) n —O— or —O—(CH 2 ) m — or —(CH 2 ) m —O—, or n is 1 or 2; and m is 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.