Patent ID: 7855291

Claim:
A method of preparing a compound of formula I(a): which comprises contacting a compound of formula II: with a compound of formula III: under conditions sufficient for the formation of the compound of formula I(a), wherein: A is optionally substituted cycloalkyl, aryl, or heterocycle; X is O, S, or NR 6 ; Y 1 is halogen; P 1 is R 1 or a protecting group; P 2 is a protecting group; P 3 is OR 2 , SR 2 , NR 9 R 10 , or NHNHR 9 ; R 1 is hydrogen or optionally substituted alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; R 2 is hydrogen or optionally substituted alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; R 3 is hydrogen, cyano, or optionally substituted alkyl or aryl; R 4 is hydrogen, cyano, or optionally substituted alkyl or aryl; R 6 is hydrogen or optionally substituted alkyl or aryl; R 7 is independently hydrogen, cyano, nitro, halogen, OR 8 , NR 9 R 10 , or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; each R 8 is independently hydrogen or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; each R 9 is independently hydrogen, a protecting group, or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; each R 10 is independently hydrogen, a protecting group, or optionally substituted alkyl, alkyl-aryl or alkyl-heterocycle; and n is 1-4.