Patent ID: 8043825

Claim:
A method for qualifying Chagas disease status in a human subject comprising: a. measuring two or more biomarkers in a biological sample from the subject, wherein the two or more biomarkers comprise a fragment of a human fibronectin polypeptide and a fragment of a human ApoA1 polypeptide, wherein: i. the fragment of the fibronectin polypeptide is an 28.5 kDa N-terminal fragment, and ii. the fragment of the ApoA-1 polypeptide is selected from the group consisting of an 14 kDa C-terminal fragment, an 25 kDa N-terminal fragment, an 9 kDa C-terminal fragment, and an 10 kDa C-terminal fragment; and b. correlating the measurement with Chagas disease status, wherein the correlating comprises comparing the measurement to a diagnostic amount, the diagnostic amount distinguishing a positive Chagas disease status from a negative Chagas disease status.