Patent ID: 8163760

Claim:
A method for the treatment of a glioma brain tumor in a subject in need thereof comprising administering an effective amount of a compound of formula (IC): in which R 2 is H; optionally substituted C 1-6 alkyl; optionally substituted C 2-6 alkenyl; optionally substituted C 2-6 alkynyl; optionally substituted C 3-6 cycloalkyl; optionally substituted aryl; CN; OR 6 , SR 6 , COR 6 , CSR 6 , HCNOR 6 or HCNNR 6 in which R 6 is H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; NR 8 R 9 or SO 2 NR 8 R 9 in which R 8 and R 9 are independently selected from H, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted aryl and optionally substituted heterocyclyl; CONR 9 R 10 in which R 9 is as defined above and R 10 is optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; CH 2 CONR 8 R 9 in which R 8 and R 9 are as defined above; and (CH 2 ) n NR 9 R 11 in which R 9 is as defined above and R 11 is selected from optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl and SO 2 R 12 in which R 12 is optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted aryl or optionally substituted heterocycyl and n is 1 to 6; R 5 and R 7 are independently selected from H, optionally substituted C 1-6 alkyl and halo; and r is 1 or 2 or salts, tautomers and/or stereo isomers thereof to a subject in need thereof.