Patent ID: 7247621

Claim:
A nucleotide analog having a structure according to Formula 1 or Formula 2, wherein Z 1 and Z 2 are independently H, alkyl, halogen, OR 5 , SR 5 , NR 5 R 6 , CO-alkyl, CO-aryl, or CO-alkoxyalkyl, and wherein W is H, OR 5 , SR 5 , NR 5 R 6 , NH(NR 5 R 6 ), N(alkyl)(NR 5 R 6 ), CN, C(O)NR 5 R 6 , C(NH)NR 5 R 6 , or halogen; wherein V is hydrogen, halogen, OR 5 , SR 5 , NR 5 R 6 , NH(NR 5 R 6 ), N(alkyl)(NR 5 R 6 ), CN, C(O)NR 5 R 6 , or C(NH)NR 5 R 6 , and wherein Y is H, alkyl, halogen, OR 5 , SR 5 , NR 5 R 6 , CO-alkyl, CO-aryl, or CO-alkoxyalkyl; X is a covalent bond between the C4′-atom of the sugar and the carbon atom in the phosphonate group, O, CH 2 , CHR 5 , CHHalogen, or C(Halogen) 2 ; D is CH 2 , CHHalogen, or C(Halogen) 2 ; R 1 R 2 are independently H, or phosphate; R 1 ′, R 2 ′, R 3 ′, and R 4 ′ are independently H or alkyl, with the proviso that at least one of R 1 ′, R 2 ′, R 3 ′, and R 4 ′ is alkyl; R 3 and R 4 are independently H, phosphate, acyl, or alkyl; R 5 and R 6 are independently H, alkyl, or acyl.