Patent ID: 7112440

Claim:
A method of increasing the relative number of CD45 low cells in an untreated starting cell population, wherein the starting cell population comprises a CD45 low cell sub-population and a CD45 high sub-population, and wherein the cells of the CD45 low sub-population have a lower relative density of CD45 antigen on their cell surface as compared to the cells of the CD45 high sub-population, and wherein the starting cell population includes committed hemopoietic cells comprising CD45 antigen, which method comprises: (i) determining that the starting cell population comprises a CD45 low cell sub-population and a CD45 high sub-population (ii) contacting the starting cell population with an agent selected from the group consisting of an antibody to the alpha chain of the MHC class I antigen, an antibody to the beta chain of the MHC class I antigen, an antibody to the alpha chain of the MHC class II antigen, and an antibody to the beta chain of the MHC class II antigen and (iii) incubating the starting cell population with the agent, whereby as a result of the contacting, a treated cell population is produced, in which the number of CD45 low cells is increased relative to the number of CD45 high cells.