Patent ID: 8008303

Claim:
A compound which is a biphenyl derivative of formula (I), a pharmaceutically acceptable salt, or a mixture thereof wherein: R i is -A 1 -L 1 -A 1 ′; A 1 is a non-fused, unsubstituted phenyl group; L 1 is —CH 2 — or —CH 2 CH 2 —; A 1 ′ is a piperazinyl group which is substituted by an unsubstituted —SO 2 —(C 1 -C 4 alkyl); A is —CONH—; B is —NH—CO—NH—, —NH—CO— or —CO—NH—; R 2 and R 3 are the same or different and each represent C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy or halogen; n and m are the same or different and each represent 0 or 1; R 4 is a C 1 -C 6 alkyl group or a moiety selected from the group consisting of -A 4 , -L 4 -A 4 , -A 4 -A 4 ′, -L 4 -A 4 -A 4 ′, -A 4 -L 4 -A 4 ′, -A 4 -Y 4 -A 4 ′, -A 4 -Het 4 -A 4 ′, -L 4 -A 4 -Y 4 -A 4 ′, -L 4 -A 4 -Het 4 -A 4 ′, -L 4 -Het 4 -A 4 , -L 4 -Y 4 -A 4 , -L 4 -Y 4 -Het 4 -A 4 , -L 4 -Het 4 -Y 4 -A 4 , -L 4 -Y 4 -Het 4 -L 4 ′, -A 4 -Y 4 -Het 4 -A 4 ′, -A 4 -Het 4 -Y 4 -A 4 ′, -A 4 -Het 4 -L 4 -A 4 ′, -A 4 -L 4 -Het 4 -A 4 ′ and -L 4 -Het 4 -L 4 ′, each A 4 , and A 4 ′ are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C 3 -C 8 carbocyclyl moiety; L 4 is a C 1 -C 4 alkylene or a C 1 -C 4 hydroxyalkylene group; Y 4 is —CO—, —SO— or —S(O) 2 —; L 4 ′ is hydrogen or a C 1 -C 4 alkyl group; and Het 4 is —O—, —S— or —NR′—, wherein R′ is hydrogen or a C 1 -C 4 alkyl group; the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R 4 are optionally fused to a phenyl, 5- to 10- membered heteroaryl or 5- to 10- membered heterocyclyl ring; and the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R 4 are unsubstituted or substituted by (a) a single unsubstituted substituent selected from —(C 1 -C 2 alkyl)-X 1 , —CO 2 R″′, —SO 2 R″′, —SO 2 NR′R″′, —CONR′R″′, —NR′—CO—R″′, —NR′—SO 2 —R″′ and —CO—NR′—(C 1 -C 2 alkyl)—NR′R″′ and/or (b) 1, 2 or 3 unsubstituted substituents selected from —(C 1 -C 2 alkyl)—X 2 , halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 hydroxyalkyl, hydroxy, cyano and —NR′R″, wherein X 1 is —CO 2 R″′, —NR′-CO 2 —R″′, —-NR′—S(O) 2 —R″′ or —SO 2 NR′R″′, each X 2 is the same or different and is cyano or —NR′R″, each R′ and R″ are the same or different and represent hydrogen or C 1 -C 4 alkyl and each R″′ is the same or different and represents C 1 -C 4 alkyl.