Patent ID: 7393852

Claim:
A compound of Formula I wherein q is 1; wherein t is 1; wherein X is selected from NH; wherein R is selected from: a) 1,2,3,4-tetrahydronaphth-1-yl; or 1,2,3,4-tetrahydronaphth-2-yl which may be substituted with one to three basic moieties, and optionally substituted with one to three groups independently selected from halo, hydroxyl, cyano, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , (C 1 -C 6 )alkyl, substituted (C 1 -C 6 )alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, substituted saturated or partially saturated heterocyclyl and unsubstituted saturated or partially saturated heterocyclyl wherein R 1 is selected from H, C 1-4 -alkyl; wherein R 2 is selected from aryl wherein R 2 is optionally substituted with one to five groups independently selected from halo, —NH 2 , hydroxyl, cyano, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , or (C 1 -C 6 )alkyl; wherein R 3 , R 3a , R 4 , R 4a , R 5 and R 5a are independently selected from H, C 1-3 alkyl and substituted C 1-3 alkyl; or wherein R 3 and R 3a together form oxo, or R 4 and R 4a together form oxo, or R 5 and R 5a together form oxo; wherein R 8 and R 8′ independently are H or selected from lower alkyl, aryl and heteroaryl, each of which is optionally substituted with one, two or three groups independently, selected from lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, and trifluoromethyl; wherein R x is selected from H, (C 1 -C 3 )haloalkyl, and (C 1 -C 3 )alkyl; and wherein each substituted alkyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl and substituted saturated or partially saturated heterocyclyl is substituted with one to three groups independently selected from halo, —NH 2 , hydroxyl, cyano, (C 1 -C 6 )alkylamino, (C 1 -C 6 )haloalkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ , or pharmaceutically acceptable salts thereto provided the basic substiuent is not 2-pyridyl, 3-pyridyl or 2-oxo-piperaziny-4-ylmethyl.