Patent ID: 8039453

Claim:
A compound of Formula (I) as follows: where: R 1 is: alkenyl; alkynyl; aryl; heterocyclyl; halogen; CN; CH(O); COR 5 ; C(O)NR 5 R 6 ; C(O)NHR 5 ; C(O)NH 2 ; C(O)NHNH 2 ; C(O)NR 5 NH 2 ; C(O)NR 5 NHR 6 ; C(O)NR 5 NR 6 R 7 ; C(O)NHNHR 5 ; C(O)NHNR 5 R 6 ; C(O)NHOH; SO 2 NHNH 2 ; SO 2 NR 5 NH 2 ; SO 2 NR 5 NHR 6 ; SO 2 NR 5 NR 6 R 7 ; SO 2 NHNHR 5 ; SO 2 NHNR 5 R 6 ; CO 2 R 5 ; SR 5 ; SSR 5 ; SO 2 NHR 5 ; SO 2 NR 5 R 6 ; B(OR 5 ) 2 ; CF 3 ; SH; SO 2 NH 2 ; NH 2 ; NHR 5 ; NHSO 2 R 5 ; NR 5 R 6 ; NHCOR 5 ; NR 5 COR 6 ; or NR 5 SO 2 R 6 ; SOR 5 ; SO 2 R 5 ; OR 7 ; or R 2 =alkyl or CH(O); R 3 =hydrogen, alkyl, or C(O)R 5 ; R 4 =hydrogen or C(O)R 5 ; R 5 , R 6 , and R 7 each are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, or heterocyclyl; R 8 =hydrogen, halogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, acyl, or thioalkyl; R 5 and R 6 could form a ring or R 6 and R 7 could form a ring; X=OR 5 , NR 5 R 6 , NHNH 2 , NHNHC(O)R 5 , OH, NHR 5 , NH 2 , or NHNHC(O)H; R 4 and X may be linked together with intervening atoms to form a ring; R 1 and R 8 may be linked together; or a pharmaceutically acceptable salt thereof, wherein the alkyl and alkenyl groups may be branched, straight, unsubstituted, and/or substituted and wherein the aryl, alkynyl, and heterocyclyl groups are substituted or unsubstituted.