Patent ID: 7687529

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein: Y is C(R 3 ) 2 , C═O, or C═N—C≡N; Z is S, O, NR 6 ,or C(R 5 ) 2 ; n is an integer from 0 to 4; R 1 is, independently at each occurrence, alkyl, alkoxy, halo, CF 3 , OCF 3 , arylalkyloxy substituted with 0 to 3 R 7 , aryloxy substituted with 0 to 3 R 7 , aryl substituted with 0 to 3 R 7 , heteroaryl substituted with 0 to 3 R 7 , hydroxy, alkanoyloxy, nitro, cyano, alkenyl, alkynyl, alkylsulfoxide, phenylsulfoxide substituted with 0 to 3 R 7 , alkylsulfone, phenylsulfone substituted with 0 to 3 R 7 , alkylsulfonamide, phenylsulfonamide substituted with 0 to 3 R 7 , heteroaryloxy substituted with 0 to 3 R 7 , heteroarylmethyloxy substituted with 0 to 3 R 7 , alkylamido, or arylamido substituted with 0 to 3 R 7 ; R 2 is aryl substituted with 0 to 3 R 1 or heteroaryl substituted with 0 to 3 R 1 ; R 3 is, independently at each occurrence, H or C 1 to C 4 alkyl; R 4 is, independently at each occurrence, H, C 1 to C 4 alkyl, arylalkyl, heteroarylmethyl, or cyclobutylmethyl cycloheptylmethyl, cyclohexylmethyl, cyclopentylmethyl, or cyclobutylmethyl; R 5 is, independently, C 1 to C 4 alkyl, C 3 to C 6 branched alkyl, C 3 to C 6 cycloalkyl, aryl substituted with 0 to 3 R 1 ; or heteroaryl substituted with 0 to 3 R 1 ; or two R 5 , together with the carbon through which they are attached, form a carbocyclic ring of 3 to 7 carbons; R 6 is H, C 1 to C 6 alkyl, C 3 to C 6 branched alkyl, C 3 to C 6 cycloalkyl, aryl substituted with 0 to 3 R 1 , or heteroaryl substituted with 0 to 3 R 1 ; R 7 is, independently at each occurrence, alkyl, alkoxy, halo, CF 3 , OCF 3 , hydroxy, alkanoyloxy, nitro, cyano, alkenyl, alkynyl, alkylsulfoxide, alkylsulfone, alkylsulfonamide, or alkylamido; R 8 is, independently at each occurrence, H, F, C 1 to C 6 alkyl, C 3 to C 6 branched alkyl, or C 3 to C 6 cycloalkyl; and wherein 1 to 3 carbon atoms in ring A may optionally be replaced with N.