Patent ID: 8680140

Claim:
A method for alleviating or preventing hot flashes, hair loss/thinning, cognitive decline associated with menopause, and combinations thereof in a patient comprising administering to the patient an effective amount of a formulation comprising three or more phytoestrogen compounds or analogues thereof that selectively bind to estrogen receptor beta and cross the blood brain barrier, the formulation not containing compounds that preferentially bind to estrogen receptor alpha, wherein the patient is a menopausal or post-menopausal woman; the three or more phytoestrogen compounds are selected from the group consisting of genistein, daidzein, equol, IBSO03569, and combinations thereof, and are administered in an effective amount from about 0.1 mg/kg/day to about 20 mg/kg/day; and the phytoestrogen compounds are more effective in combination than the same amount of the individual phytoestrogen compounds.