Patent ID: 7723294

Claim:
A multilayer film, said film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes, wherein a first layer polyelectrolye comprises a hybrid polypeptide comprising a first polypeptide segment and a second polypeptide segment covalently joined by one or more non-peptidic linikages; wherein the first polypeptide segment comprises a polypeptide segment having a magnitude of net charge per residue of greater than or equal to 0.4, and a length of greater than or equal to about 12 amino acid residues; wherein the second polypeptide segment comprises an antigenic determinant region selected from the group consisting of a viral antigen, a bacterial antigen, a fungal antigen, a parasite antigen, a tumor antigen, or a combination thereof; the N-terminus of the first polypeptide segment is joined to the C-terminus of the second polypeptide segment, the N-terminus of the first polypeptide segment is joined to the N-terminus of the second polypeptide segment, the C-terminus of the first polypeptide segment is joined to the C-terminus of the second polypeptide segment, or the C-terminus of the first polypeptide segment is joined to the N-terminus of the second polypeptide segment; and wherein a second layer comprises a second layer polyelectrolyte comprising a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule, and a charge opposite that of the first layer polypeptide.