Patent ID: 8207205

Claim:
A compound of formula I: wherein: X and Y are different and are either N or O; R 1 is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, alkoxy, substituted alkoxy, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkyloxy, substituted cycloalkyloxy, cycloalkenyl, substituted cycloalkenyl, cycloalkenyloxy, substituted cycloalkenyloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, aryloxy and substituted aryloxy; R 2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl; or when p is 0, R 1 and R 2 together with the atoms bound thereto, form a heterocycle or substituted heterocycle; R 3 and R 4 are each independently halo; R 5 is selected from the group consisting of hydrogen and hydroxyl; R 6 is selected from the group consisting of hydrogen, alkyl and substituted alkyl; and p is 0, 1, 2, or 3; or a pharmaceutically acceptable salt, isomer, or tautomer thereof wherein said compound exhibits at least one of the following: a) an IC 50 of less than 30 μM in a T84 assay to test inhibition of a CFTR channel; b) a greater than 30% inhibition at 20 μM in a Fisher rat thyroid (FRT) assay to test inhibition of a CFTR channel; or c) a greater than 35% inhibition at 50 μM in a T84 assay to test inhibition of a CFTR channel, provided that the compound does not have an IC 50 greater than 30 μM.