Patent ID: 8178521

Claim:
A method for preparing cefazolin sodium pentahydrate crystal comprising: adding 1-20 parts of a solvent to a reactor equipped with a jacket; adding 1 part of cefazolin acid and sodium salt in a molar ratio of about 1:1 to provide a reaction solution; heating until the reaction solution is clear; adjusting pH to 3-9; upon the completion of the reaction, transferring the liquid to a crystallizer equipped with a jacket; cooling in water bath; adding crystallization additives; holding for 0.3-4 hours at 0.8-2.5 atmospheric pressure; cooling at the temperature range of 0° C.-70° C., adding 3-15 parts of an antisolvent, filtering, washing with a detergent, and drying to provide cefazolin sodium pentahydrate.