Patent ID: 7786121

Claim:
A compound of formula (I), or an enantiomer or diastereoisomer thereof, or a salt thereof: wherein Ar represents an phenyl optionally substituted by at least one substituent selected from (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, hydroxy, hydroxy(C 1 -C 3 )alkyl, mercapto, mercapto(C 1 -C 3 )alkyl, (C 1 -C 3 )alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile (—CN), —COOH, —COOR A , —COR A , —SO 2 R A , —CONH 2 , —SO 2 NH 2 , —CONHR A , —SO 2 NHR A , —CONR A R B , —SO 2 NR A R B , —NH 2 , —NHR A , —NR A R B , —OCONH 2 , —OCONHR A , —OCONR A R B , —NHCOR A , —NHCOOR A , —NR B COOR A , —NHSO 2 OR A , —NR B SO 2 OR A , —NHCONH 2 , —NR A CONH 2 , —NHCONHR B , —NR A CONHR B , NHCONR A R B , or —NR A CONR A R B wherein R A and R B are independently C 1 -C 3 alkyl, phenyl or a 5- or 6-membered monocyclic aryl or heteroaryl ring; R represents hydrogen or C 1 -C 6 alkyl, or C 3 -C 6 cycloalkyl; Alk represents a divalent C 1 -C 5 alkylene or C 2 -C 5 alkenylene radical; and R 1 and R 2 taken together with the nitrogen atom to which they are attached form a piperazinyl ring optionally substituted by at least one group of formula (II): wherein m, p and n are independently 0 or 1; Z represents, hydrogen, or an optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms which is optionally fused to another optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms; Alk 1 and Alk 2 independently represent optionally substituted divalent C 1 -C 3 alkylene radicals; X represents — 0 —, —S—, —S(O)—, —S(O 2 )—, —C(=O)—, —NH—, —NR 3 —, —S(O 2 )NH—, —S(O 2 )NR 3 —, —NHS(O 2 )—, or —NR 3 S(O 2 )—, where R 3 is C 1 -C 3 alkyl; and wherein, except for Ar defined above, optionally substituted means at least one substituent selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, hydroxy(C 1 -C 6 )alkyl, mercapto, mercapto(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, halo, trifluoromethyl, trifluoromethoxy, nitro, nitrile (—CN), oxo, phenyl, —COOH, —COOR C , —COR C , —SO 2 R C , —CONH 2 , —SO 2 NH 2 , —CONHR C , —SO 2 NHR C , —CONR C R D , —SO 2 NR C R D , —NH 2 , —NHR C , —NR C R D , —OCONH 2 , —OCONHR C , —OCONR C R D , —NHCOR C , —NHCOOR C , —NR D COOR C , —NHSO 2 OR C , —NR D SO 2 OR C , —NHCONH 2 , —NR C CONH 2 , —NHCONHR D , —NR C CONHR D , —NHCONR C R D or —NR C CONR C R D wherein R C and R D are independently a (C 1 -C 6 )alkyl or phenyl group.