Patent ID: 6878846

Claim:
A method for the production of a bisphosphonate of formula (I) wherein: X=OH Y=R or R 1 R=C 1 to C 8 alkyl R 1 =C 1 to C 8 amine, ester or pyridyl or X and Y together form a cyclic structure wherein one of X and Y is represents an aza group; by reacting a carbonyl compound of general formula: wherein: X=OH, amine, ester or halide Y=R or R 1 R is C 1 to C 8 alkyl R 1 is C 1 to C 8 amine, ether or pyridyl or X and Y together form a cyclic structure wherein one of X and Y represents an aza group, with a phophorus halide, in a carrier/solvent system consisting essentially of (a) an amine hydrochloride (b) phosphorous acid (c) phosphoric acid, and wherein said method does not produce any orange pyrophoric solid.