Patent ID: 7368471

Claim:
A method for the treatment of Alzheimer's disease in mammal, comprising administering to a mammal in need thereof a pharmaceutically effective amount of a compound of Formula I wherein: X is a chemical bond, —CH 2 — or —C(O)—; R 1 is C 1 -C 8 alkyl, (—CH 2 ) n —C 3 -C 6 cycloalkyl, wherein n is an integer of from 0 to 3, pyridinyl, —CH 2 -pyridinyl, phenyl or benzyl, the rings of the cycloalkyl, pyridinyl, phenyl and benzyl groups being optionally substituted by, from 1 to 3 groups selected from, halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OH, —NH 2 , or —NO 2 ; R 2 is H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, C 1 -C 3 perfluoroalkyl, —CH 2 OH or CH 2 OAc; R 3 is H, halogen, C 1 -C 6 alkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl, —CH 2 —C 3 -C 6 cycloalkenyl, —NH 2 , or —NO 2 ; R 4 is C 3 -C 6 cycloalkyl, —CH 2 —C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl, —CH 2 —C 3 -C 6 cycloalkenyl, phenyl, benzyl, pyridinyl, or —CH 2 -pyridinyl, with the rings of these groups being optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OH, —NH 2 , —NO 2 or (CO)C 1 -C 6 alkyl; or a pharmaceutically acceptable salt or ester form thereof.