Patent ID: 7498308

Claim:
A method of treating a subject suffering stroke comprising administering to the subject an effective amount of a Glucagon-Like Peptide-1 (GLP-1) compound of formula 1 (SEQ ID NO:1) Formula 1 His-Xaa 8 -Glu-Gly-Xaa 11 -Xaa 12 -Thr- (SEQ ID NO: 1) Ser-Asp-Xaa 16 -Ser-Ser-Tyr-Leu-Glu- Xaa 22 -Xaa 23 -Xaa 24 -Ala-Xaa 26 -Xaa 27 - Phe-Ile-Xaa 30 -Trp-Leu-Xaa 33 -Xaa 34 - Xaa 35 -Xaa 36 -R wherein: Xaa 8 is: Gly or Val; Xaa 11 is: Asp, Glu, Arg, Thr, Ala, Lys, or His; Xaa 12 is: His, Trp, Phe, or Tyr; Xaa 16 is: Leu, Ser, Thr, Trp, His, Phe, Asp, Val, Tyr, Glu, or Ala; Xaa 22 is: Asp, Glu, Gln, Asn, Lys, Arg, Cys, or Cysteic Acid; Xaa 23 is: His, Asp, Lys, Glu, Gln, or Arg; Xaa 24 is: Glu, Arg, Ala, or Lys; Xaa 26 is: Trp, Tyr, Phe, Asp, Lys, Glu, or His; Xaa 27 is: Ala, Glu, His, Phe, Tyr, Trp, Arg, or Lys; Xaa 30 is: Ala, Glu, Asp, Ser, or His; Xaa 33 is: Asp, Arg, Val, Lys, Ala, Gly, or Glu; Xaa 34 is: Glu, Lys, or Asp; Xaa 35 is: Thr, Ser, Lys, Arg, Trp, Tyr, Phe, Asp, Gly, Pro, His, or Glu; Xaa 36 is: Thr, Ser, Asp, Trp, Tyr, Phe, Arg, Glu, or His; R is: Lys, Arg, Thr, Ser, Glu, Asp, Trp, Tyr, Phe, His, —NH 2 , Gly, Gly-Pro, or Gly-Pro-NH 2 , or is deleted, and wherein the GLP-1 compound demonstrates insulinotropic activity.