Patent ID: 7052857

Claim:
A eukaryotic host cell which has been genetically engineered by the introduction of three olfactory channel subunit encoding nucleic acid sequences which upon expression result in a heteromeric olfactory cyclic nucleotide gated (CNG) channel and further by the introduction of a nucleic acid sequence encoding an exogenous G protein coupled receptor wherein said heteromeric olfactory CNG channel is comprised of (i) a OCNC1 olfactory channel subunit polypeptide which exhibits at least 99% sequence identity to the polypeptide of SEQ. ID NO: 9 or 12; (ii) a OCNC2 olfactory channel subunit polypeptide which exhibits at least 99% sequence identity to the polypeptide of SEQ. ID NO: 10 and (iii) a β1b olfactory CNG channel subunit polypeptide which exhibits at least 99% sequence identity to the polypeptide of SEQ. ID NO: 11.