Patent ID: 8586103

Claim:
A liquid composition for sustained release of a bioactive substance, consisting essentially of: (a) sucrose acetate isobutyrate; (b) a solvent selected from the group consisting of acetone, benzyl alcohol, butylene glycol, caprolactam, caprolactone, dimethylsulfoxide, ethanol, ethyl acetate, ethyl lactate, glycerol, glycerol formal, glycofurol, tetraglycol, N-methyl-2-pyrrolidone, polyethylene glycol, methoxy polyethylene glycol, alkoxy polyethylene glycol, propylene carbonate, 2 pyrrolidone, triacetin and triethyl citrate; and (c) an ionic complex that is formed between a bioactive substance having a net charge at neutral pH in water and an amphiphilic molecule, wherein the amphiphilic molecule is selected from the group consisting of dialkyl ester sulfosuccinic acid, dioctyl sulfosuccinic acid, benzenesulfonic acid, camphorsulfonic acid, (+)-(1S)camphor-10-sulfonic acid, dodecylsulfuric acid, naphthalene-2-sulfonic acid, naphthalene-1,5-disulfonic acid, para-toluenesulfonic acid, cholesterol sulfuric acid and heptanesulfonic acid.