Patent ID: 7811590

Claim:
A non-typeable Haemophilus influenza major outer membrane P5chimeric protein comprising: a first region comprising amino acids 1 to 37 of SEQ ID NO: 9; a second region comprising a first loop selected from the group consisting of amino acids 38 to 57 of SEQ ID NO: 9, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8; a third region comprising amino acids 58 to 88 of SEQ ID NO: 9; a fourth region comprising a second loop selected from the group consisting of amino acids 89 to 100 of SEQ ID NO: 9, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8; a fifth region comprising amino acids 101 to 135 of SEQ ID NO: 9; a sixth region comprising a third loop selected from the group consisting of amino acids 136 to 150 of SEQ ID NO: 9, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8; a seventh region comprising amino acids 151 to 180 of SEQ ID NO: 9; an eighth region comprising a fourth loop selected from the group consisting of amino acids 181 to 204 of SEQ ID NO: 9, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8; and a ninth region comprising amino acids 205 to 353 of SEQ ID NO: 9, wherein at least one of the first, second, third, or fourth loops comprise an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8, and wherein the regions are covalently linked, respectively.