Patent ID: 8227603

Claim:
A method for increasing time to fast skeletal muscle fiber fatigue, the method comprising: selectively binding troponin C in the troponin complex of the fast skeletal muscle fiber; and allowing said fast skeletal muscle fiber to respond with enhanced force or increased time to fatigue as compared to a fast skeletal muscle fiber having at least some troponin C which is not selectively bound, wherein the troponin C is bound with a compound of Formula I or Formula II: or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from alkenyl and alkynyl; R 4 is hydrogen; and R 2 is selected from 3-pentyl, 4-heptyl, 4-methyl-1-morpholinopentan-2-yl, isobutyl, cyclohexyl, cyclopropyl, sec-butyl, tert-butyl, isopropyl, 1-hydroxybutan-2-yl, tetrahydro-2H-pyran-4-yl, 1-methoxybutan-2-yl, 1-aminobutan-2-yl, and 1-morpholinobutan-2-yl; provided that R 1 is not hex-1-enyl; and allowing said fast skeletal muscle fiber to respond with enhanced force or increased time to fatigue as compared to a fast skeletal muscle fiber having at least some troponin C which is not selectively bound.