Patent ID: 8043806

Claim:
A method of diagnosing a receptor tyrosine kinase (RTK) hyperfunction-induced disorder or a genetic predisposition therefor in a mammal, wherein the RTK hyperfunction-induced disorder is associated with a mutated fibroblast growth factor receptor-4 (FGFR-4) protein, which method comprises determining the presence or absence of a nucleic acid encoding a mutated fibroblast growth factor receptor-4 (FGFR-4) protein having an increased activity as compared to a wild-type FGFR 4 protein in a sample of nucleic acid obtained from the mammal, wherein the presence of such a nucleic acid is indicative of an RTK-hyperfunction-induced disorder or a genetic predisposition therefor that is associated with a mutated FGFR-4 protein.