Patent ID: 8637036

Claim:
An isolated human monoclonal antibody comprising: a heavy chain comprising a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3, and a light chain comprising a light chain variable region comprising a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3, wherein the HCDR1, HCDR2, and HCDR3 comprise amino acids 26-33, 51-58, and 97-110 of SEQ ID NO: 1, respectively; and the LCDR1, LCDR2, and LCDR3 comprise amino acids 27-30, 48-50, and 87-91 of SEQ ID NO: 2, respectively, and the antibody specifically binds to a CD4 binding site on the surface of gp120 and neutralizes HIV-1.