Patent ID: 8778681

Claim:
A method for producing hematopoietic progenitor cells or erythroid progenitor cells, which comprises culturing cells selected from the group consisting of pluripotent stem cells and cells at a differentiation stage between pluripotent stem cells and hematopoietic progenitor cells, and increasing an oxygen partial pressure from a low oxygen partial pressure of up to 10% to a higher oxygen partial pressure of at least 11% during said culturing of said cells, thereby producing the hematopoietic progenitor cells or the erythroid progenitor cells, wherein the low oxygen partial pressure is increased to the higher oxygen partial pressure when an indicator gene is expressed that indicates expression of a differentiation induction and the gene is selected from the group consisting of mesendoderm induction, hematopoietic progenitor cell induction, differential proliferative cytokine, and blood cell induction.