Patent ID: 8288094

Claim:
A method for identifying a compound that increases hA3A, hA3C or hA3H activity in a cell comprising (i) contacting a cell expressing hA3A, hA3C or hA3H with a test compound and a substrate for hA3H, and measuring the level of cytidine deaminase activity, (ii) in a separate experiment, contacting a cell expressing hA3A, hA3C or hA3H and a substrate for hA3A, hA3C or hA3H in the absence of a test compound, and measuring the level of cytidine deaminase activity, where the conditions are essentially the same as in part (i) and then (iii) comparing the level of cytidine deaminase activity measured in part (i) with the level of cytidine deaminase activity in part (ii), wherein an increase level of cytidine deaminase activity in the presence of the compound indicates that the compound is a compound that increases hA3A, hA3C or hA3H activity in a cell.