Patent ID: 8686148

Claim:
A process for preparing tiotropium salts of formula 1 wherein X âˆ’ denotes an anion other than Y âˆ’ , optionally in the form of solvates or hydrates thereof, selected from the group consisting of fluoride, chloride, bromide, iodide, C 1 -C 4 -alkylsulphate, sulphate, hydrogen sulphate, phosphate, hydrogen phosphate, dihydrogen phosphate, nitrate, maleate, acetate, trifluoroacetate, citrate, fumarate, tartrate, oxalate, succinate and benzoate, C 1 -C 4 -alkylsulphonate, which may optionally be mono-, di- or trisubstituted by fluorine at the alkyl group, or phenylsulphonate, which may optionally be mono- or polysubstituted by C 1 -C 4 -alkyl at the phenyl ring, comprising reacting a tiotropium salt of formula 2 wherein Y âˆ’ denotes an anion other than X âˆ’ , selected from the group consisting of halide, C 1 -C 10 -alkyl sulphonate, C 1 -C 10 -alkyl sulphate, C 6 -C 10 -aryl sulphonate, optionally in the form of solvates or hydrates thereof, in a suitable solvent with an ion source Kat-X wherein Kat denotes a cation and X has the same definition as X âˆ’ above, and wherein the cation Kat of compounds Kat-X is selected from alkali or alkaline earth metals, ammonium (NH 4 + ) or tetralkylammonium (N(C 1 -C 8 -alkyl) 4 + .