Patent ID: 8247401

Claim:
A compound of structural formula I: or pharmaceutically acceptable salts and individual enantiomers and diastereomers thereof wherein: X and Y independently represent N, or CR 1 ; R 6 represents OH, (CH 2 ) n CF 3 , SO 2 R 2 , N(R 2 ) 2 , C(R 2 ) 2 OR 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocyclyl, said alkyl substituted and said alkenyl, alkynyl, aryl and heterocyclyl optionally substituted with 1 to 3 groups of R a , provided said heterocyclyl is not thiazolyl, benzthiazolyl, oxazolyl, isoxazolyl, dihydro-isoxazolyl, or oxadiazolyl, provided that when R 6 is (CH 2 ) n C 5-10 heterocyclyl it is not tetrazolyl; R 1 represents H, C 1-6 alkyl, halogen, (CH 2 ) n CF 3 , C 3-10 cycloalkyl, C(R 2 ) 2 OH, —O—, CN, (CH 2 ) n OR 2 , (CH 2 ) n C 5-10 heterocyclyl, (CH 2 ) n C 6-10 aryl, or C 1-6 alkoxy; said alkyl, cycloalkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of C 1-6 alkyl, halogen, hydroxyl, (CH 2 ) n CF 3 , or CN; R 2 represents H, C 1-6 alkyl, CF 3 , OH; R 3 represents —CR 2 R 4 R 5 , —(C(R 2 ) 2 ) n C 3-10 cycloalkyl, —(C(R 2 ) 2 ) n C 5-10 heterocycle, said cycloalkyl and heterocyclyl optionally substituted with 1 to 3 groups of R a ; or R 2 and R 3 can be combined with the nitrogen to which they are attached to form a C 5-10 heterocyclyl optionally substituted with 1 to 3 groups of R a ; R 4 and R 5 independently represent H, (CH 2 ) n OR 2 , (CH 2 ) n C 5-10 heterocyclyl, (CH 2 ) n C 6-10 aryl, C 3-10 cycloalkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n CF 3 , CHF 2 , CN, C(O) 1-2 R 2 , or C 1-6 alkyl; said alkyl, cycloalkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of R a , provided that when R 3 is —CR 2 R 4 R 5 and the R 4 is substituted by R a , the R a substituent is not N(R 4 ) 2 ; R a represents C 1-6 alkyl, halogen, —CHF 2 , —(CH 2 ) n CF 3 , —O—, C 3-6 cycloalkyl, NR 2 C(O)R 2 , C(O)N(R 2 ) 2 , C(R 2 ) 2 OR 2 , C(O)R 2 , NO 2 , CN, N(R 2 ) 2 , C(O)OR 2 , SO 2 R 2 , OR 2 , (CH 2 ) n C 5-10 heterocyclyl, or (CH 2 ) n C 6-10 aryl, said alkyl, heterocyclyl and aryl optionally substituted with 1 to 3 groups of C 1-6 alkyl, halogen, OR 2 , N(R 4 ) 2 , C(O)N(R 2 ) 2 , (CH 2 ) n CF 3 , or CN; and n represents 0 to 4.