Patent ID: 8314103

Claim:
A compound of formula (I): wherein, A is nitrogen and B is carbon; R 1 is selected from hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxy, alkoxy, aryl, and aryloxy, or is absent; R 2 is selected from hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxy, alkoxy, aryl, and aryloxy; R 3 is selected from hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxy, alkoxy, aryl, aryloxy, and —O—R 6 ; or R 2 and R 3 together with the N atom to which they are attached form an unsubstituted or substituted heterocycle selected from 1,2,4-oxadiazole or pyrimidine; R 4 and R 5 are independently selected from hydrogen, alkyl, haloalkyl, aralkyl, alkenyl, alkynyl, aryl, heterocyclyl, cycloalkyl, —O—R 6 , and —C(O)-T-Q; R 6 is selected from alkenyl and alkynyl; wherein the alkenyl and alkynyl may be unsubstituted or substituted; T is selected from —(CR 7 R 8 ) n — and —C(R 7 R 8 )C(O)—, where n is an integer from 0 to 5; R 7 and R 8 are independently selected from hydrogen, alkyl, haloalkyl, cycloalkyl, alkenyl, halogen, hydroxy, alkoxy, cyano, nitro, aryl, and heterocyclyl; and Q is selected from hydrogen, hydroxy, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy, cycloalkyl, and heterocyclyl; where, in R 1 , R 2 , R 3, R 4 , R 5 , R 7 , R 8 and Q: alkyl and cycloalkyl are unsubstituted or substituted with at least one group selected from halogen, hydroxy, carboxy, acetoxy, amino, cycloalkyl, alkoxy, aryloxy, alkoxycarbonyl, aminocarbonyl, aminoaryl, aryl, aralkyl, and heterocyclyl; aryl is unsubstituted or substituted with at least one group selected from halogen, nitro, alkyl, haloalkyl, alkoxy, amino, heteroarylalkyl, heterocyclyl, aryl, and aralkyl; and heterocyclyl is unsubstituted or substituted with at least one group selected from halogen, hydroxy, alkoxy, oxo, alkyl, haloalkyl, alkenyl, alkynyl, aryloxy, cycloalkyl, cycloalkylalkyl, acyl, acyloxy, amino, aminoalkyl, hydroxyalkyl, heterocyclylalkyl, heteroarylalkyl, aralkyl, alkylaminoalkyl, formyl, alkylcarbonyl, arylcarbonyl, alkylamino, alkylheteroarylamino, alkoxycarbonyl, aryloxycarbonyl, —COOH, —C(O)—O—R 6 , and —O—R 6 ; with a proviso that: when R 1 is selected from hydrogen, alkyl, alkenyl, alkynyl, acyl, hydroxy, alkoxy, aryl, and aryloxy, then at least one of R 4 and R 5 is —C(O)-T-Q; with a further proviso that: when Q or any one of R 7 and R 8 is selected from cycloalkyl, heterocyclyl, and aryl; then a) R 2 and R 3 are independently selected from groups other than hydrogen and hydroxy; and b) if R 2 and R 3 together with the N atom to which they are attached forms a ring, then the ring is not a 5-membered heterocycle; and stereoisomeric and tautomeric forms and mixtures thereof in all ratios, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable polymorphs thereof.