Patent ID: 7232431

Claim:
A method for sonoporation for intradermal delivery of a microparticles suspension containing a beneficial substance to be released into an area of a patient's skin comprising; (a) providing a container having a first end and a second end, said second end having thereon a ring of skin-removable resilient medical adhesive material and being covered by a removable protective film; (b) submerging the tip of an ultrasound horn in said microparticles suspension through said first end of the container; (c) removing the protective film; and (d) placing said second end in contact with an area of a patient's skin intended to receive said beneficial substance and (e) applying ultrasound radiation to said microparticles suspension at a frequency, an intensity, for a period of time, and at a distance from the skin, effective to generate cavitation bubbles, wherein said cavitation bubbles collapse and transfer their energy into the skin area thus causing the formation of pores in the skin area; and wherein said ultrasound radiation intensity and distance from the skin area are also effective in generating ultrasonic jets, said ultrasonic jets driving said microparticles through said formed pores into the skin area with a majority of the microparticles remaining intact.