Patent ID: 8802851

Claim:
A process for preparing vilazodone, or a hydrochloride form thereof comprising the steps of A) reacting 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile of formula (I) with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride of formula (II) to give 5-{4-[4-(5-cyano-1H-indol-3-yl)-4-hydroxybutyl]-piperazin-1-yl}benzofuran-2-carboxylate methyl of formula (III) B) treating the compound of formula (III), obtained from step A, with an acidification agent to obtain 5-{4-[4-(5-cyano-1H-indol-3-yl)-4-hydroxy-butyl]-piperazin-1-yl}benzofuran-2-carboxylate methyl of formula (IV) C) hydrogenating the compound of formula (IV) with H 2 to obtain 5-{4-[4-(5-cyano-1H-indol-3-yl)-4-hydroxy-butyl]-piperazin-1-yl}benzo-furan-2-carboxylate methyl of formula (V) D) treating the compound of formula (V) obtained from step C) with ammonia to obtain 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzo-furan-2-carboxamide of formula (VI), E) optionally treating the compound of formula (VI) with hydrochloride acid to obtain vilazodone hydrochloride of formula (VII)