Patent ID: 7935704

Claim:
A method for treating a condition in an animal, comprising administering to the animal a compound in an amount that is effective to reduce vascular proliferation or in an amount that is effective to reduce vascular density, wherein the condition is selected from the group consisting of breast cancer, colon cancer, lung cancer, prostate cancer, melanoma, angiofibroma, Kaposi sarcoma, hemangioma, acoustic neuroma, and neurofibroma, wherein the compound has the structure of Formula (I) wherein R 1 is selected from the group consisting of a hydrogen atom, a halogen atom, hydroxy, and cyano, or selected from the group consisting of saturated C 1 - C 24 alkyl, unsaturated C 1 -C 24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, amino, nitro, azido, phenyl, carboxy, —CO—O—R 7 , alkylthio, halogenated alkyl including polyhalogenated alkyl, halogenated carbonyl, and carbonyl —CCO—R 7 , each optionally substituted with one or more of alkoxy, cycloalkyl, cycloalkenyl, acyl, aclyamino, acyloxy, amino, aminoacyl, aminoacyloxy, oxyacylamino, cyano, halogen, hydroxy, carboxy, carboxyalkyl, aryl, arlyoxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-aryl, —SO 2 -alkyl, and —SO 2 -aryl; R 7 is selected from a hydrogen atom or a halogen atom or selected from the group consisting of saturated C 1 -C 24 alkyl, unsaturated C 1 -C 24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, amino, substituted amino, nitro, azido, and phenyl groups, each optionally substituted with one or more of alkoxy, cycloalkyl, cycloalkenyl, acyl, aclyamino, acyloxy, amino, aminoacyl, aminoacyloxy, oxyacylamino, cyano, halogen, hydroxy, carboxy, carboxyalkyl, aryl, arlyoxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-aryl, —SO 2 -alkyl, and —SO 2 -aryl; R 4 is a branched alkyl or branched alkenyl group; R 1 ′ and R 1 ″ are each independently selected from the group consisting of a hydrogen atom, a halogen atom, hydroxy, and cyano, or independently selected from the group consisting of saturated C 1 -C 24 alkyl, unsaturated C 1 -C 24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, amino, nitro, azido, phenyl, carboxy, —CO—O—R 7 , alkylthio, halogenated alkyl including polyhalogenated alkyl, halogenated carbonyl, and carbonyl —CCO—R 7 , each optionally substituted with one or more of alkoxy, cycloalkyl, cycloalkenyl, acyl, aclyamino, acyloxy, amino, aminoacyl, aminoacyloxy, oxyacylamino, cyano, halogen, hydroxy, carboxy, carboxyalkyl, aryl, arlyoxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO- aryl, —SO 2 -alkyl, and —SO 2 -aryl; R, R 1 ′ and R 1 ″ are either covalently bound to one another or are not covalently bound to one another; R 2 , R 3 , R 5 , and R 6 are hydrogen; X 1 and X 2 are oxygen; Y is a nitrogen atom; n is an integer equal to one; Z, Z 1 , Z 2 , Z 3 and Z 4 are each a carbon atom; and the dashed bonds may be either single or double bonds.