Patent ID: 6841161

Claim:
A topical composition for mutual enhancement of transdermal permeation of at least a first and a second pharmaceutically acceptable components which are both pharmacologically active agents, the composition comprising an emulsion of at least one discontinuous phase in a continuous phase, the at least one discontinuous phase comprising a eutectic mixture of at least first and second pharmacologically active agents and the continuous phase comprising a pharmaceutically acceptable carrier, the eutectic mixture having a melting point below 40° C.; and at least one compatible emulsifying agent, wherein the first pharmacologically active agent is selected from the group consisting of chlorocresol, chlorbutanol, methyl nicotinate, triprolidine, promethazine, trimeprazine, sulfiram, oxybutynin, testosterone enanthate, and choline salicylate, wherein the second pharmacologically active agent is selected from the group consisting of chlorocresol, trimeprazine, choline salicylate, methyl nicotinate, ibuprofen, ketoprofen, fenoprofen, flurbiprofen etodolac, fentanyl, econzole, ketoconazole, mupirocin, chlorbutanol, clindamycin, iodine, oxybutynin, tetramisole, triprolidine, promethazine, and propranolol, in which the at least two pharmacologically active agents are structurally and/or pharmacologically diverse, wherein when the first pharmacologically active agent is a local anesthetic, the second pharmacologically active agent is not a local anaesthetic, wherein when the second pharmacologically active agent is a local anesthetic, the first pharmacologically active agent is not a local anesthetic, and wherein the first and the second pharmacologically active agents are each a prophylactic or a therapeutic agent.