Patent ID: 7790724

Claim:
A compound of Formula II: or a hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein A is phenyl, pyridinyl, pyridazinyl, or piperidinyl; wherein A can be optionally substituted with one or more of —C 1-6 alkyl, —C 2-6 alkenyl, amino, aminoalkyl, hydroxyalkyl, alkoxyalkyl, sulfonamidoalkyl, alkylsulfonamidoalkyl, guanidinoalkyl, heteroaryl, alkoxyheteroaryl, aminoheteroaryl, halogen, hydroxy, —CF 3 , alkoxy, aryl, aminoaryl, aralkyl, heteroaralkyl, aryloxy, arylalkoxy, —OCF 3 , —OCO-alkyl, —COR a , —CN, —C(NH)NH 2 , —COOR a , —CONR a R b , —N(R a )COR b , —NO 2 , —SO 2 R a , —SO 3 R a or —SO 2 NR a R b ; -arylNSO 2 R a ; or -alkyl SO 2 NR a R b ; R 1 is H; X is —CO—; Y is a direct link; R 2 is cycloalkyl which is a saturated or partially unsaturated ring composed of from 3 to 8 carbon atoms, methylimidazolyl, piperidinyl, or methylpiperidinyl; W is imidazolyl, optionally substituted with —C 1-6 alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, alkoxyalkyl, heteroaryl, halogen, hydroxy, —CF 3 , alkoxy, aryl, aralkyl, heteroaralkyl, aryloxy, arylalkoxy, —OCF 3 , —OCO-alkyl, —OCO-alkylamino, —OCO-alkylamido, —COR a , —CN, —C(NH)NH 2 , —COOR a , —CONR a R b , —N(R a )COR b , —NO 2 , —SO 2 R a , —SO 3 R a or —SO 2 NR a R b ; and R a and R b are independently hydrogen, alkyl, carboxyl, alkylcarboxyl, hydroxyalkyl, cycloalkyl, haloalkyl, aryl, aralkyl, heteroaralkyl, heterocyclyl or heteroaryl.