Patent ID: 7510835

Claim:
A method for determining whether a human subject is at an increased risk or decreased risk of breast cancer, which comprises: (a) detecting in a nucleic acid of the human subject the presence of a polymorphic variant selected from the group consisting of a guanine corresponding to position 7573 of SEQ ID NO: 2, a guanine corresponding to position 13903 of SEQ ID NO: 2, an adenine corresponding to position 23826 of SEQ ID NO: 2, an adenine corresponding to position 26057 of SEQ ID NO: 2, a thymine corresponding to position 26361 of SEQ ID NO: 2, an adenine corresponding to position 26599 of SEQ ID NO: 2, an adenine corresponding to position 26812 of SEQ ID NO: 2, a cytosine corresponding to position 27069 of SEQ ID NO: 2, an adenine corresponding to position 35127 of SEQ ID NO: 2, a thymine corresponding to position 35222 of SEQ ID NO: 2, a cytosine corresponding to position 36424 of SEQ ID NO: 2, a cytosine corresponding to position 46176 of SEQ ID NO: 2, a cytosine corresponding to position 50452 of SEQ ID NO: 2, a guanine corresponding to position 61093 of SEQ ID NO: 2, an adenine corresponding to position 62572 of SEQ ID NO: 2, a guanine corresponding to position 70759 of SEQ ID NO: 2, and the complement of the foregoing; or (b) detecting in a nucleic acid of the human subject the presence of a polymorphic variant selected from the group consisting of an adenine corresponding to position 7573 of SEQ ID NO: 2, a cytosine corresponding to position 13903 of SEQ ID NO: 2, a thymine corresponding to position 23826 of SEQ ID NO: 2, a guanine corresponding to position 26057 of SEQ ID NO: 2, a cytosine corresponding to position 26361 of SEQ ID NO: 2, a guanine corresponding to position 26599 of SEQ ID NO: 2, a guanine corresponding to position 26812 of SEQ ID NO: 2, a thymine corresponding to position 27069 of SEQ ID NO: 2, a guanine corresponding to position 35127 of SEQ ID NO: 2, a guanine corresponding to position 35222 of SEQ ID NO: 2, a thymine corresponding to position 36424 of SEQ ID NO: 2, a guanine corresponding to position 46176 of SEQ ID NO: 2, a thymine corresponding to position 50452 of SEQ ID NO: 2, a cytosine corresponding to position 61093 of SEQ ID NO: 2, a guanine corresponding to position 62572 of SEQ ID NO: 2, an adenine corresponding to position 70759 of SEQ ID NO: 2, and the complement of the foregoing; whereby it is determined that the subject is at an increased risk of breast cancer based on the presence of one or more of the polymorphic variants of (a), and whereby it is determined that the subject is at a decreased risk of breast cancer based on the presence of one or more of the polymorphic variations of (b).