Patent ID: 8404461

Claim:
A method for preparing carbamic acid aryl-2-tetrazoyl ethyl ester of the Chemical Formula 1, comprising: subjecting an arylketone of the Chemical Formula 2, to enantioselective enzymatic reduction in a reaction mixture comprising said compound, an oxidoreductase having at least 90% homology with amino acid sequence SEQ ID NO: 2, NADH or NADPH as a cofactor that is oxidized during the reduction process and continuously regenerated, a second substrate comprising a secondary alcohol having the Formula RR′CHOH, wherein R and R′ are independent from one another and have from 1 to 10 carbon atoms, and a suitable buffer to form an alcohol compound of (R)-configuration, of Chemical Formula 3; and carbamating said alcohol wherein, R 1 and R 2 are independently selected from the group consisting of hydrogen, halogen, perfluoroalkyl, an alkyl of 1 to 8 carbon atoms, a thioalkoxy of 1 to 8 carbon atoms, and an alkoxy of 1 to 8 carbon atoms; and one of A 1 and A 2 is CH with the other being N.