Patent ID: 8741286

Claim:
A chimeric thrombin-cleavable derivative of factor X, wherein at least one of arginine, lysine and serine of the chimeric derivative of factor X corresponding to residues at positions 387, 391 and 419, respectively, of SEQ ID NO:1 is replaced by alanine, and wherein a native activation peptide of the factor X is replaced by a fusion protein comprising a first polypeptide comprising an amino acid sequence ranging from positions 33 to 52 of SEQ ID NO: 2, wherein asparagine at at least one of positions 39 and 49 is N-glycosylated; and a second polypeptide comprising an amino acid sequence ranging from positions 7 to 16 of SEQ ID NO: 4 including variants thereof wherein the glycine at position 14 of SEQ ID NO: 4 is replaced by valine, phenylalanine or alanine and/or the valine at position 15 of SEQ ID NO: 4 is replaced by proline.