Patent ID: 8357703

Claim:
A compound of formula I wherein X is O or NH; R 1 is a) lower-alkyl or lower-alkoxy, each optionally substituted with 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, hydroxy and lower-alkoxy, or b) cycloalkyl or heterocyclyl, each optionally substituted with 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, hydroxy, lower-alkyl and lower-alkoxy; R 2 is hydrogen or lower-alkyl optionally substituted with 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano and lower-alkoxy; R 3 is hydrogen or lower-alkyl optionally substituted with 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, hydroxy and lower-alkoxy; R 4 is lower-alkyl, cycloalkyl, heterocyclyl or heteroaryl, each optionally substituted with 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, lower alkyl and lower-alkoxy; or wherein R 3 and R 4 , together with the nitrogen atom to which they are attached, form a heterocyclyl, optionally substituted with 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, hydroxy, lower-alkyl, lower-alkoxy and oxo; or a pharmaceutically acceptable salt and ester thereof.