Patent ID: 8324250

Claim:
A compound of formula I wherein R 1 is aryl optionally substituted by halogen, lower alkyl substituted by halogen; R 2 is CRR′-aryl or heteroaryl, each of which is optionally substituted by halogen, lower alkyl, lower alkyl substituted by halogen or cyano, CRR′-cycloalkyl, CRR′-lower alkyl, or NR-aryl or NR-heteroaryl, wherein aryl and heteroaryl are each optionally substituted by halogen, lower alkyl, lower alkyl substituted by halogen or cyano, or is NR-cycloalkyl, indan-1-yl or indan-2-yl, each of which is optionally substituted by hydroxy; R 3 is hydrogen or lower alkyl, or R 2 and R 3 together with the N-atom to which they are attached form a 2,3-dihydro-1-H-isoindol group or a piperidine ring, which is optionally substituted by a heteroaryl group; R and R′ are each independently hydrogen, (CH 2 ) n -cycloalkyl, lower alkyl, lower alkyl substituted by halogen or hydroxy, or R and R′ together with the carbon atom to which they are attached form a cycloalkyl ring; is aryl, optionally substituted by lower alkyl or ═O, or is cycloalkyl; is heteroaryl, optionally substituted by lower alkyl, lower alkoxy, halogen, lower alkyl substituted by halogen, cyano, amino, C(O)-lower alkyl, C(O)NH 2 , S(O) 2 -lower alkyl or ═O, or is cycloalkyl; or a pharmaceutically active salt thereof.