Patent ID: 7914810

Claim:
A method for in situ treatment of malignant cells from a cancer associated with bone, which comprises positioning among the malignant cells an implant with a coating layer that at least partially chemically and/or physically associates with at least one active agent for treating the malignant cells, with the proviso that the implant does not comprise a hardened bone cement within the bulk of which the at least one active agent is contained, wherein the at least one active agent is selected from the group consisting essentially of: a monophosphonate or a bisphosphonate selected from the group consisting of etidronate, clodronate, pamidronate, alendronate, olpadronate, amino-olpadronate, ibandronate, neridronate, nedrinate, medronate, tiludronate, risedronate, zolendronate, EB-1053, YM-175, CGP 42′446, YM 529, U-81581, FR-78844, BM-21.0955, and a combination thereof; combined with vitamin D, a vitamin D derivative, calcitonin, or a combination thereof.