Patent ID: 7872127

Claim:
A compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 and R 4 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R 5 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R 6 and R 7 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; or R 6 and R 7 together with the nitrogen atom to which they are attached form a heterocycle selected from the group consisting of piperidinyl, piperizinyl, pyrrolidinyl, imidazolidinyl, imidazolinyl, indolinyl, morpholinyl, pyrazolidinyl, and pyrazolinyl; A 1 is heteroaryl selected from the group consisting of pyridyl, pyrimidinyl, 1,3,5-triazinyl, quinolyl, furyl and thienyl, any of which is optionally substituted with halo, haloalkyl, aryl, cycloalkyl, alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkylalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyol, alkoxyalkyl, nitro, amino, ureido, cyano, acylamino, hydroxy, thiol, acyloxy, azido, alkoxy, carboxy, aminocarbonyl or alkylthiol; A 2 is aryl, optionally substituted with halo, haloalkyl, aryl, cycloalkyl, alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkylalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, alkoxyalkyl, nitro, amino, ureido, cyano, acylamino, hydroxy, thiol, acyloxy, azido, alkoxy, carboxy, aminocarbonyl or alkylthiol, or two adjoining positions on the aryl ring form a —OCH 2 O—, —OCF 2 O—, —(CH 2 ) 3 —, —(CH 2 ) 4 —, —OCH 2 CH 2 O—, —CH 2 N(R 18 )CH 2 —, —CH 2 CH 2 N(R 18 )CH 2 —, or —CH 2 N(R 18 )CH 2 CH 2 — bridge, wherein R 18 is hydrogen, alkyl or cycloalkyl; X is one of O, S, NR 8 , CH 2 , SO, SO 2 or a covalent bond, wherein: R 8 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; and n is 0, 1, 2 or 3.