Patent ID: 7932254

Claim:
A compound of Formula I wherein: R is R 1 , R 2 , R 3 , or R 4 ; R 1 is lower alkyl, lower alkoxy, phenyl, benzyl, heteroaryl, cycloalkyl, heterocycloalkyl, or cycloalkylalkyl, optionally substituted with one or more R 1a ; R 1a is R 1b or R 1c ; R 1b is halogen, oxo, hydroxy, or —CN; R 1c is —C(═O)O(R 1f ), —C(═O)CH 2 (R 1e ), —S(R 1f ), —S(O) 2 (R 1f ), or —S(═O) (R 1f ), lower alkyl, lower alkoxy, amino, amido, lower haloalkyl, phenyl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkyloxy, or heterocycloalkyloxy optionally substituted with one or more R 1d ; R 1d is H, halogen, hydroxy, lower alkyl, lower alkoxy, or lower haloalkyl; R 1e is H, lower alkyl, lower alkoxy, —CN, lower haloalkyl, phenyl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 1f is H, lower alkyl, lower haloalkyl, phenyl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 2 is N(R 2a ) 2 ; each R 2a is independently H or R 2b ; each R 2b is independently lower alkyl, phenyl, heteroaryl, cycloalkyl, heterocycloalkyl, or heterocycloalkyl alkylene, optionally substituted with one or more R 2c ; R 2c is R 2d or R 2e ; R 2d is halogen, oxo, or hydroxy; R 2e is —N(R 2g ) 2 , —C(═O)(R 2g ), —C(═O)O(R 2g ), —C(═O)N(R 2g ) 2 , —N(R 2g )C(═O)(R 2g ), —S(═O) 2 (R 2g ), —S(O) 2 N(R 2g ) 2 , lower alkyl, lower alkoxy, lower haloalkyl, phenyl, heteroaryl, heteroaryloxy, cycloalkyl, or heterocycloalkyl, optionally substituted with one or more R 2f ; each R 2f is independently H, halogen, lower alkyl, lower alkoxy, lower haloalkyl; each R 2g is independently H, lower alkyl, lower alkoxy, lower haloalkyl, or phenyl; R 3 is —C(═O)R 3a ; R 3a is lower alkyl, lower alkoxy, phenyl, or N(R 3b ) 2 ; each R 3b is independently H or lower alkyl; R 4 is —O(R 4a ); R 4a is H or R 4b ; R 4b is lower alkyl, phenyl, benzyl, lower haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, optionally substituted with one or more R 4c ; R 4c is halogen, hydroxy, lower alkyl, lower haloalkyl, or lower alkoxy; Q 1 is optionally substituted with one or more Q 1b or Q 1c ; A is heterocycloalkyl or heteroaryl; Q 1b is halogen, hydroxy, oxo, or —CN; Q 1c is Q 1d or Q 1e ; Q 1d is —O(Q 1e ), —S(Q 1e ), —S(═O)(Q 1e ), —S(═O) 2 (Q 1e ), —C(═O)N(Q 1e ) 2 , —N(Q 1e )S(═O) 2 (Q 1e ), —C(═O)(Q 1e ), —C(═O)O(Q 1e ), —N(Q 1e ) 2 , —N(Q 1e )C(═O)(Q 1e ), —N(Q 1e )C(═O)O(Q 1e ), or —N(Q 1e )C(═O)N(Q 1e ) 2 ; each Q 1e is independently H or Q 1e′ ; each Q 1e′ is independently lower alkyl, lower alkenyl, phenyl, benzyl, lower haloalkyl, lower hydroxyalkyl, cycloalkyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q 1f ; Q 1f is Q g or Q 1h ; Q 1g is halogen, hydroxy, oxo, —C(═O)(Q 1h ), or —N(Q 1h )C(═O)(Q 1h ); each Q 1h is independently H, lower alkyl, lower haloalkyl, lower alkoxy, lower hydroxyalkyl, amino, phenyl, benzyl, cycloalkyl, heterocycloalkyl, or heteroaryl, optionally substituted with one or more Q 1i ; each Q 1i is independently halogen, hydroxy, lower alkyl, lower haloalkyl, or lower alkoxy; or a pharmaceutically acceptable salt thereof.