Patent ID: 7199119

Claim:
A compound having the formula (Ia.1): or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof, wherein R 1 is selected from the group consisting of —C(O)NR 1a R 1b , —C(O)R 1a , —CH(═NOH), —N(R 1b )C(O)R 1a , —SO 2 NR 1a R 1b , —SO 2 R 1a , —C(O)N(R 1a )OR 1b , —(C 1 –C 4 )alkylene —N(R 1b )C(O)R 1a , and —(C 1 –C 4 )alkylene-C(O)NR 1a R 1b ; wherein R 1a and R 1b are selected from hydrogen, (C 1 –C 6 )alkyl, (C 2 –C 4 )alkenyl, (C 2 –C 6 )heteroalkyl, hydroxy(C 1 –C 4 )alkyl, fluoro(C 1 –C 4 )alkyl, cyano(C 1 –C 4 )alkyl, cyclo(C 3 –C 8 )alkyl, mono- or di-hydroxycyclo(C 3 –C 8 )alkyl; R 2 is selected from the group consisting of —NR 2a R 2b and —OH; wherein R 2a and R 2b are selected from hydrogen, (C 1 –C 6 )alkyl, (C 2 –C 4 )alkenyl, (C 2 –C 6 )heteroalkyl, mono- or di-hydroxy(C 1 –C 4 )alkyl, fluoro(C 1 –C 4 )alkyl, cyano(C 1 –C 4 )alkyl, cyclo(C 3 –C 8 )alkyl, mono- or di-hydroxycyclo(C 3 –C 8 )alkyl, aryl, aryl(C 1 –C 4 )alkyl, —C(O)—(C 1 –C 4 )alkyl, —C(O)—(C 1 –C 4 )alkoxy, C(O)-fluoro(C 1 –C 4 )alkyl; L is a single bond, Q is selected from the group consisting of furyl, thienyl, thiazolyl, isothiazolyl, triazolyl, imidazolyl, oxazolyl, isoxazolyl, pyrrolyl, pyrazolyl, benzofuryl, tetrahydrobenzofuryl, isobenzofuryl, benzthiazolyl, benzoisothiazolyl, benzotriazolyl, indolyl, isoindolyl, benzoxazolyl, benzimidazolyl, benzisoxazolyl and benzothienyl, wherein each of the moieties is optionally further substituted; X 1 , X 2 and X 3 are independently selected from the group consisting of ═C—and —CH—; Y 1 and Y 3 are independently selected from the group consisting of ═C(R 5a )—, —C(R 5 )(R 6 )—; Y 2 is —S(O) m ; Y 4 is ═N—or —N(R 5 )—; Z 1 and Z 2 are CH or ═C—; each R 5 and R 6 is independently selected from the group consisting of hydrogen, (C 1 –C 6 )alkyl, cyclo(C 3 –C 8 )alkyl, aryl, aryl(C 1 –C 4 )alkyl, hetero(C 1 –C 6 )alkyl, and arylhetero(C 1 –C 4 )alkyl; each R 5a is independently selected from the group consisting of hydrogen, halogen, (C 1 –C 6 )alkyl, cyclo(C 3 –C 8 )alkyl, aryl, aryl(C 1 –C 4 )alkyl, hetero(C 1 –C 6 )alkyl, and arylhetero(C 1 –C 4 )alkyl; and the subscript m is 0.