Patent ID: 8772457

Claim:
An isolated antibody, or fragment thereof, that binds to β-site amyloid precursor protein cleaving enzyme 1 (BACE1) comprising (a) an HVR-H1 comprising the amino acid sequence GFTFX 13 GYX 14 IH (SEQ ID NO:26), wherein X 13 =S or L and X 14 =A or G, (b) an HVR-H2 comprising the amino acid sequence of GWISPAGGSTDYADSVKG (SEQ ID NO:24), (c) an HVR-H3 comprising the amino acid sequence of GPFSPWVMDY (SEQ ID NO:25), (d) an HVR-L1 comprising the amino acid sequence of RASQX 1 VX 2 X 3 X 4 X 5 A (SEQ ID NO:17), wherein X 1 =D or V; X 2 =S or A; X 3 =T or N; X 4 =S or A; X 5 =V or L, (e) an HVR-L2 comprising the amino acid sequence of X 6 ASFLYS (SEQ ID NO:18) wherein X 6 =S or L, and (f) an HVR-L3 comprising the amino acid sequence of QQX 7 X 8 X 9 X 10 X 11 X 12 T (SEQ ID NO:19), wherein X 7 =S, F, G, D or Y; X 8 =Y, P, S, or A; X 9 =T or N; X 10 =T, Y, D or S; X 11 =P or L; X 12 =P or T, and wherein the antibody reduces or inhibits the activity of the BACE1 polypeptide.