Patent ID: 8609687

Claim:
A compound of Formula I enantiomers, diastereomers, tautomers or pharmaceutically acceptable salts thereof, wherein: R 1 is C(O)OR a , phenyl, C 1 -C 9 heterocyclyl or C 1 -C 9 heteroaryl, wherein said phenyl and heteroaryl are optionally substituted by 1 to 5 R 6 ; R 2 is phenyl, C 1 -C 9 heteroaryl or C 1 -C 9 heterocyclyl, wherein the phenyl, heteroaryl and heterocyclyl are optionally substituted by 1 to 5 R 7 ; R 3 , R 4 and R 5 are independently H, CH 3 , CH 2 CH 3 , CF 3 , F or Cl; R 6 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 0 -C 6 alkyl)OR a , (C 0 -C 6 alkyl)NR a R b , halo, CN, CF 3 , S(O) 1-2 NR a R b , C(O)R a , NR a C(O)OR b , NR a S(O) 1-2 NR b , (C 0 -C 6 alkyl)C 1 -C 5 heteroaryl, (C 0 -C 6 alkyl)C 1 -C 5 heterocyclyl, (C 0 -C 6 alkyl)C 3 -C 6 cycloalkyl, (C 0 -C 6 alkyl)C 6 -C 9 aryl, (C 0 -C 6 alkyl)C(O)OR a , C(O)(C 0 -C 5 alkyl)NR a R b , C(O)(C 0 -C 5 alkyl)(C 1 -C 5 heterocyclyl), C(O)NR a (C 0 -C 5 alkyl)(C 1 -C 5 heterocyclyl), C(O)NR a (C 0 -C 5 alkyl)(C 3 -C 6 cycloalkyl), C(O)NR a (C 0 -C 5 alkyl)(C 1 -C 5 heteroaryl), C(O)NR a (C 1 -C 5 alkyl)NR a R b or C(O)NR a (C 1 -C 5 alkyl)(C 6 aryl), wherein said alkyl, alkenyl and alkynyl are optionally substituted by 1 to 5 substituents independently selected from OR a , NR c R d , oxo and halo, and said aryl, heterocyclyl, heteroaryl and cycloalkyl are optionally substituted by 1 to 5 substituents independently selected from OR a , oxo, halo, CF 3 , NR c R d , C 1 -C 4 alkyl, (C 0 -C 6 alkyl)C 1 -C 5 heterocyclyl and C(O)(C 1 -c 4 alkyl); R 7 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 0 -C 6 alkyl)OR a , (C 0 -C 6 alkyl)NR a R b , (C 0 -C 6 alkyl)(C 6 -C 9 aryl), halo, C(O)NR a R b , NR a C(O)R b , SO 2 (C 1 -C 6 alkyl), SO 2 NR a R b , CN, CF 3 , CH 2 CF 3 , nitro, S(O)(C 1 -C 6 alkyl), S(O)NR a R b , NR a S(O) 1-2 R b ,C(O)R a , C(O)OR a , (C 0-C 6 alkyl)C 1 -C 5 heteroaryl, (C 0 -C 6 alkyl)C 1 -C 5 heterocyclyl or (C 0 -C 6 alkyl)C 3 -C 6 cycloalkyl, wherein said alkyl, alkenyl and alkynyl are optionally substituted by 1 to 5 substituents independently selected from oxo, NR a R b , OR a , and halo, and said aryl, heteroaryl, heterocyclyl and cycloalkyl are optionally substituted by 1 to 5 substituents independently selected from OR a , halo, CF 3 , NR c R d and C 1 -C 4 alkyl; R a and R b are independently H, OR c , C(O)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 6 aryl or C 3 -C 6 cycloalkyl, wherein said alkyl, aryl and cycloalkyl are optionally substituted by 1 to 5 substituents independently selected from C 1 -C 4 alkyl, (C 0 -C 3 alkyl)OR c , oxo, halo, NR c R d and C 4 -C 5 heterocyclyl; or R a and R b together with the atom to which they are attached form a C 1 -C 5 heterocyclyl; and R c and R d are independently H, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl or phenyl, wherein said alkyl, cycloalkyl and phenyl are optionally substituted by 1 to 5 substituents independently selected from halo, CH 3 OH or NH 2 , C(O)O(C 1 -C 6 alkyl) and C(O)NH(C 1 -c 6 alkyl).