Patent ID: 7186752

Claim:
A compound of the formula wherein Φ is phenylene with 1 to 2 substituents selected from the group consisting of hydrogen, halogen, —OH, and alkyl or alkoxy of 1 to 6 carbon atoms; A is W is a bond; R 1 , R 2 , R 3 , R 4 , R 5 are individually selected from the group consisting of hydrogen, halogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, cyano, nitro and —NR 6 R 7 ; R 6 and R 7 are individually selected from the group consisting of hydrogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, and —COR 8 , R 8 is selected from the group consisting of hydrogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, and —NR 9 R 10 , R 9 and R 10 are individually selected from the group consisting of hydrogen, —OH or alkyl of 1 to 6 carbon atoms, B is selected from the group consisting of —CH 2 —NO 2 ; alkyl of 1 to 6 carbon atoms; —NR 13 R 14 ; and unsubstituted or substituted carbocyclic aryl or heterocyclic aryl carbocyclic or heterocyclic aryl of 5 to 6 ring members containing 1 to 4 heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen, the aryl substituents being selected from the group consisting of alkyl alkenyl and alkoxy of up to 6 carbon atoms, R 13 and R 14 are individually selected from the group consisting hydrogen, alkyl of 1 to 6 carbon atoms, cyano, nitro radical, or together with the nitrogen form a non aromatic heterocycle of 5 to 6 ring members, selected from the group consisting of —CH 2 —, —NH—, —O—or —S—; X is selected from the group consisting of a bond, —(CH 2 ) k —NR 16 —, —O—, —S—, —CO—, —NR 16 —CO—, —CO—NR 16 —, —O—CO—, —CO—O—, —NR 16 —CO—O—, —NR 16 —CO—NR 17 —, k representing 0 or 1; Y is selected from the group consisting of a bond, —(CH 2 ) m —, —(CH 2 ) m —O—(CH 2 ) n —, —(CH 2 ) m —S—(CH 2 ) n —, —(CH 2 ) m —NR 18 —(CH 2 ) n —, —(CH 2 ) m —NR 18 —CO—(CH 2 ) n —, —(CH 2 ) m —CO—NR 18 —(CH 2 ) n —, —(CH 2 ) m -Q-(CH 2 ) n —, Q is selected from the group consisting of piperazine, homopiperazine, 2-methylpiperazine, 2,5-dimethylpiperazine, 4-oxypiperidine or 4-aminopiperidine radicals, m and n are individually integers from 0 to 6; R 16 , R 17 and R 18 are individually hydrogen or akyl of 1 to 6 carbon atoms; and a pharmaceutically acceptable salt thereof.