Patent ID: 8906377

Claim:
A stably tethered structure comprising: a) two copies of a first fusion protein comprising a dimerization and docking domain (DDD) selected from the group consisting of residues 1-44 of human protein kinase A RIIα and RIIβ fused to a first protein or peptide, wherein the first protein or peptide is an antibody or antigen-binding fragment thereof; and b) one copy of a second fusion protein comprising the amino acid sequence selected from the group consisting of the anchoring domain (AD) of A-kinase anchoring protein (AKAP) fused to a second protein or peptide, wherein the second protein or peptide is an antibody or antigen-binding fragment thereof; wherein the two copies of the DDD bind to the AD to form a stably tethered structure and wherein antibody or antigen-binding fragment thereof is selected from the group consisting of hMN-14 (anti-CEACAM5), hA20 (anti-CD20), hLL1 (anti-CD74), hLL2 (anti-CD22), h679 (anti-HSG), hL243 (anti-HLA-DR), hR1 (anti-IGF-1R), hPAM4 (anti-mucin), hMN-15 (anti-CEACAM6), h734 (anti-indium-diethylenetriamine-pentaacetate) or hRS7 (anti-EGP-1).