Patent ID: 7053057

Claim:
A compound of formula I: wherein: Ring A is an optionally substituted tetrahydroquinoline or tetrahydroisoquinoline ring; R 1 is —H, —CHN 2 , —R, or —CH 2 Y; R is an optionally substituted group selected from an aliphatic group, an aryl group, an aralkyl group, a heterocyclic group, or an heterocyclylalkyl group; Y is an electronegative leaving group; R 2 is CO 2 H, CH 2 CO 2 H, or esters, amides or isosteres thereof; Ar is an optionally substituted aryl group; and R 3 ′ is —H, and R 3 is —H, an optionally substituted C 1-6 alkyl, CN, or aryl; or R 3 is attached to Ar to form an unsaturated or partially saturated five or six membered fused ring having 0–2 heteroatoms; or R 3 ′ and R 3 are each —F.