Patent ID: 8178093

Claim:
A method of treating infectious disease caused by viral or bacterial pathogenic agents comprising administering to a patient in need thereof a composition comprising a pharmaceutically effective amount of selected monoclonal antibodies specific to said viral or bacterial pathogenic agents prepared by a method comprising: A) purifying a monoclonal antibody obtained from a clone derived from a cell line selected from the group consisting of a hydridoma and an animal or human cell line transfected with a vector comprising a gene encoding said antibody, B) adding the purified antibody to a reaction mixture comprising: a. target cells for said purified antibody, b. effector cells comprising cells expressing FcγRIII, and c. polyvalent IgGs, and C) determining a lysis percentage of the target cells and selecting monoclonal antibodies that activate the effector cells and causes a significant lysis of the target cells (FcγRIII-type ADCC activity) to yield the selected monoclonal antibodies.