Patent ID: 8541445

Claim:
A compound represented by structural formula I or IA: or a pharmaceutically acceptable salt thereof wherein: each ring A is independently a five membered heteroaromatic ring, ring B is five- or six-membered saturated carbocyclic or heterocyclic ring; R 2 is —H, —(CR ++ 2 ) n CN, —(CR ++ 2 ) n C(O)N(R*) 2 , —(CR ++ 2 ) n OR*, —(CR ++ 2 ) n N(R*) 2 , —(CR ++ 2 ) n N(R*)C(O)R*, or C1-10 aliphatic optionally substituted with one or more halogen, or phenyl; each R 3 and R 4 independently are —H, halogen, C1-10 aliphatic, heterocyclyl, heterocyclylalkyl, aryl, or aralkyl, wherein R 3 and R 4 are optionally and independently substituted with one or more selected from the group consisting of C1-10 alkyl, halogen, —CN, —NO 2 , —N(R*) 2 , —S(O) p R*, —S(O) p NR*, —C(O)N(R*) 2 , —NR*C(O), —OC(O)N(R*) 2 , —N(R*)C(O)OR*, —N(R*)C(O)N(R*) 2 and —OR*; or R 3 and R 4 taken together with the carbon to which they are attached form C═O, or a 3-8 membered saturated, partially saturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from the groups consisting of O, N, and S, wherein the ring is optionally and independently substituted with one or more selected from the group consisting of ═O, ═S, ═N—R*, C1-10 aliphatic, C1-10 haloaliphatic, halogen, —CN, —NO 2 , —N(R*) 2 , —S(O) p R*, —S(O) p NR*, —C(O)N(R*) 2 , —NR*C(O), —OC(O)N(R*) 2 , —N(R*)C(O)OR*, —N(R*)C(O)N(R*) 2 and —OR*; each R 5 and R 6 are independently —H, halogen, C1-10 haloaliphatic, or C1-10 aliphatic; each R 7 is independently C1-10 haloaliphatic, C1-10 aliphatic, halogen, —NO 2 , —(CR ++ 2 ) n CN, —(CR ++ 2 ) n N(R**) 2 , —(CR ++ 2 ) n OR**, or —(CR ++ 2 ) n C(O)N(R**) 2 , or two R 7 groups together with the carbon to which they are attached form C═O; each R ++ is independently —H or halogen; each R* is independently —H or C1-10 alkyl or aralkyl optionally and independently substituted with up to five halogen groups; each R** is independently —H or C1-10 alkyl optionally and independently substituted with up to five halogen groups; each n is independently 0, or 1-10; and each p is independently 0, 1, or 2.