Patent ID: 8063088

Claim:
A compound of formula (I) wherein A is —C(O); D is N; E is phenylene which can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl and fluoro-lower-alkyl; R 1 is R 4 —SO 2 ; R 2 is lower-alkyl or aryl, wherein aryl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy; R 3 is phenyl or pyridyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, COOH, lower-alkyl-SO 2 , lower-alkyl-SO 2 —NH, COOH-lower-alkyl, hydrox lower-alkyl NH 2 -lower-alkyl, NO 2 , CN, NH 2 —SO 2 and N(H,lower-alkyl)-SO 2 ; and R 4 is lower-alkyl, aryl or heteroaryl, wherein aryl or heteroaryl can optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy; and pharmaceutically acceptable salts and esters thereof.