Patent ID: 6867206

Claim:
A 6-carboxyphenyldihydropyridazinone derivative of the general formula (I) in which A, D, E and G are identical or different and represent hydrogen, halogen, trifluoromethyl or hydroxyl, or represent (C 1 -C 6 )-alkyl or represent (C 1 -C 6 )-alkoxy, R 1 and R 2 are identical or different and represent hydrogen or represent (C 1 -C 6 )-alkyl, R 3 represents radicals of the formulae —OR 4 or —NR 5 R 6 , in which R 4 denotes cycloalkyl having from 3 to 8 carbon atoms or (C 1 -C 8 )-alkyl which is optionally substituted by hydroxyl, (C 1 -C 6 )-alkoxy, cycloalkyl having from 3 to 8 carbon atoms or aryl having from 6 to 10 carbon atoms which, for its part, can be substituted, once to twice, identically or differently, by substituents which are selected from the group consisting of halogen, (C 1 -C 6 )-alkoxy, hydroxyl and trifluoromethyl, or denotes (C 1 -C 8 )-alkyl which is optionally substituted by a group of the formula —NR 7 R 8 , in which R 7 and R 8 are identical or different and denote hydrogen, (C 1 -C 6 )-alkyl or benzyl, or R 4 denotes vinyl or allyl, or R 4 denotes aryl having from 6 to 10 carbon atoms which is optionally substituted, once to twice, identically or differently, by substituents which are selected from the group consisting of halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy and hydroxyl, R 5 denotes hydrogen or (C 1 -C 4 )-alkyl, R 6 denotes cycloalkyl having from 3 to 8 carbon atoms or a radical of the formula aryl having from 6 to 10 carbon atoms or a pyridyl, thienyl, pyridazinyl, furyl, or thiazolyl group, it being possible for the ring systems which are listed here to be optionally substituted, once to several times, identically or differently, by substituents which are selected from the group consisting of halogen, trifluoromethyl, hydroxyl, (C 1 -C 6 )-alkoxy, carboxyl, (C 1 -C 6 )-alkoxycarbonyl, (C 1 -C 6 )-alkyl and radicals of the formulae —SO 2 —NR 9 R 10 and —(CO) a —NR 11 R 12 , in which R 9 , R 10 , R 11 and R 12 are identical or different and denote hydrogen or (C 1 -C 6 )-alkyl, and a denotes a number 0 or 1, or R 6 denotes (C 1 -C 8 )-alkyl which is substituted, once to twice, identically or differently, by substituents which are selected from the group consisting of halogen, trifluoromethyl, hydroxyl, (C 1 -C 6 )-alkoxy, carboxyl, (C 1 -C 6 )-alkoxycarbonyl, aryl having from 6 to 10 carbon atoms, pyridyl, thienyl, pyridazinyl, furyl, and thiazolyl, in which the ring systems can be optionally substituted, once to three times, identically or differently, by (C 1 -C 6 )-alkyl, halogen, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxycarbonyl, trifluoromethyl or by the radical —CO—NH 2 , or R 5 and R 6 form, together with the nitrogen atom, cyclic radicals of the formulae or a pharmaceutically acceptable salt thereof.