Patent ID: 8143374

Claim:
An isolated peptide consisting of the formula: (a) X 01 ValSerGluIleGlnLeuMetHisAsnLeuGlyLysHisLeuAsnSerMetX 02 X 03 X 04 GluX 05 X 06 ArgLysLysX 07 GlnAspVa1 (SEQ ID NO:1); (b) a fragment thereof, containing amino acids 1-20, 1-21, 1-22, 1-23, 1-24, 1-25, 1-26, 1-27, 1-28, 1-29, or 1-30; (c) a pharmaceutically acceptable salt thereof; or (d) an N-terminal or C-terminal derivative thereof having a modification at the free N-terminal end or free C-terminal end; wherein: X 01 is Ser or Ala; X 02 is Glu or Arg; X 03 is Ala, Arg, Glu, Gln, or cyclohexylalanine (Cha); X 04 is Val or Glu; X 05 is Trp, Ala, Glu, or Cha; X 06 is Leu, Ala, Glu, or Cha; and X 07 is Leu or Glu; provided that said peptide, said fragment thereof, said pharmaceutically acceptable salt thereof, or said N-terminal or C-terminal derivative thereof is not hPTH(1-31)NH 2 (SEQ ID NO:13), [Ala 20 ]hPTH(1-31)NH 2 (SEQ ID NO:2), [Glu 20 ]hPTH(1-31)NH 2 (SEQ ID NO:5), or [Gln 20 ]hPTH(1-31)NH 2 (SEQ ID NO:14).