Patent ID: 7026324

Claim:
A compound of the general formula: and pharmaceutically acceptable salts thereof, wherein A is 1) a 6-membered non-heterocyclic unsaturated ring system, unsubstituted, monosubstituted, disubstituted, or trisubstituted, same or different, with C 1-4 alkyl, 2) a 6-membered heterocyclic unsaturated or saturated ring system wherein 1 ring atom is selected from the group of heteroatoms consisting of N, O and S, wherein the ring carbons are unsubstituted, monosubstituted, disubstituted, or trisubstituted, same or different, with C 1-4 alkyl, where R is hydrogen or C 1-8 alkyl, or 4) —C 3-8 cycloalkyl; Z is —(CH 2 ) 2-4 —, —CF 2 (CH 2 ) 1-3 —, —(CH 2 ) 1-3 SO 2 —, —(CH 2 ) 1-2 NH(CH 2 ) 1-4 —, or —CH 2 CH(R 4 )—, where R 4 is —(CH 2 ) 1-2 N(R 5 R 6 ), and R 5 and R 6 , same or different, are selected from the group consisting of hydrogen and C 1-4 alkyl; X is CH or N; R 1 is hydrogen, halogen, or C 1-4 alkyl; R 2 is R 3 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C 1-4 alkyl, 4) C 3-7 cycloalkyl, 5) CF 3 , 6) OCF 3 , 7) C 1-4 alkoxy, and 8) cyano; R 12 is a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 1 heteroatom is N, and at most 1 of the heteroatoms is S, said ring being unsubstituted or substituted, at any one ring atom, with CH 3 .