Patent ID: 7589232

Claim:
A method of treating at least one disease, in a mammal in need thereof, wherein the at least one disease is selected from the group consisting of diabetes, inadequate glucose tolerance, hyperlipidemia, hypertriglyceridemia, hypercholerstrolemia, obesity, and polycystic ovary syndrome, comprising administering at least one alkynyl aryl carboxamide of Formula (I′) as well as its geometrical isomers, its optically active forms as enantiomers, diastereomers and its racemate forms, as well as pharmaceutically acceptable salts thereof, wherein A is a C 2 -C 15 alkynyl, or C 2 -C 6 -alkynyl aryl; Cy is an aryl; Cy′ is an aryl, which may optionally be fused by a 3-8 membered cycloalkyl; n is 0 or 1; R 1 and R 2 are independently from each other selected from the group consisting of hydrogen and C 1 -C 6 -alkyl; R 3 is selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkyl amine, C 1 -C 6 -alkyl alkoxy, C 1 -C 6 -alkyl carboxy, aryl, heteroaryl, saturated or unsaturated 3-8-membered cycloalkyl, 3-8-membered heterocycloalkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 2 -C 6 -alkenyl aryl, C 2 -C 6 -alkenyl heteroaryl, C 2 -C 6 -alkynyl aryl; C 2 -C 6 -alkynyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, C 2 -C 6 -alkenyl cycloalkyl, C 2 -C 6 -alkenyl heterocycloalkyl, C 2 -C 6 -alkynyl cycloalkyl, and C 2 -C 6 -alkynyl heterocycloalkyl; R 4 and R 5 are independently from each other selected from the group consisting of H, hydroxy, fluoro, C 1 -C 6 alkyl, carboxy, C 1 -C 6 alkoxy, C 1 -C 3 alkyl carboxy, C 2 -C 3 alkenyl carboxy, and C 2 -C 3 alkynyl carboxy, wherein at least one of R 4 or R 5 is neither a hydrogen nor a C 1 -C 6 alkyl; to the mammal in an amount sufficient to treat or prevent the at least one disease.