Patent ID: 8278326

Claim:
A compound of formula (I) comprising: wherein n is 1 or 2; Ar is phenyl or thienyl, and is optionally substituted; each R 1 is independently R 6 , C(O)R 6 , C(O)—OR 6 , or C(O)N(R 6 ) 2 ; R 2 is H or optionally substituted C1-C6 alkyl, or a group of formula —C(O)NH—R 1 ; R 3 is independently at each occurrence selected from halo, NO 2 , CN, R, OR, NR 2 ; S(O) q R, COOR, and CONR 2 , where each R is independently H, C1-C4 alkyl, or C1-C4 haloalkyl; m is 0-4; R 4 is R 6 , halo, =0, COOR 6 , CO N(R 6 ) 2 , S(O) q R 6 , N(R 6 ) 2 , or OR 6 ; p is 0-2; each q is independently 0-2; Z is 0 or NR 5 ; R 5 is R 6 or C(O)R 6 ; and R 6 is independently at each occurrence selected from H, C1-C6 alkyl, C5-C6 aryl, and (C5-C6-aryl)-C1-C6 alkyl, where each alkyl and aryl is optionally substituted; provided that n is 2 when Z is 0 and Ar represents para-halophenyl; or a pharmaceutically acceptable salt thereof.