Patent ID: 8463351

Claim:
An in vivo glucose sensor, comprising: a substrate having a narrow distal region for partial implantation through a skin surface and a wider proximal region, the substrate including at least a first surface and a second surface; at least one working electrode disposed on the narrow distal region of the substrate and in fluid contact with interstitial fluid under the skin surface, the at least one working electrode formed on the first surface of the substrate; at least one reference electrode disposed on the narrow distal region of the substrate, the at least one reference electrode formed on the first surface of the substrate; at least one counter electrode disposed on the narrow distal region of the substrate, the at least one counter electrode formed on the second surface of the substrate; a plurality of first conductive contacts disposed on the wider proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of first conductive contacts is in electrical communication with the working electrode, a second one of the plurality of first conductive contacts is in electrical communication with the reference electrode, and a third one of the plurality of first conductive contacts is in electrical communication with the counter electrode; at least one via formed through the substrate that electrically connects the counter electrode to the third one of the plurality of first conductive contacts; a sensing layer proximate to the at least one working electrode; and a mass transport limiting layer proximate to the at least one working electrode; wherein the flexibility of the sensor is varied along a continuum of the substrate.