Patent ID: 7465732

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R 1 is —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkoxy, —(C 1 -C 6 )arylalkyl, —NR a R b , hydroxy, cyano, aryl, or heteroaryl, wherein said —(C 1 -C 6 )alkyl, said aryl, or said heteroaryl is optionally substituted independently with one to three —COOH, —C(O)(C 1 -C 6 )alkoxy, —C(O)(C 1 -C 6 )alkyl, —C(O)NR a R b , cyano, halogen, nitro, trifluoromethyl, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkoxy, —(C 3 -C 6 )cycloalkyl, or phenyl, wherein: R a and R b are, independently, hydrogen, —(C 1 -C 6 )alkyl, aryl, or heteroaryl, or R a and R b , taken together with the nitrogen atom to which they are attached, form a four- to six-membered heterocyclic ring, wherein said ring optionally incorporates an additional one or two nitrogen, oxygen, or sulfur ring heteroatoms; R 2 and R 3 are, independently, hydrogen, halogen, —(C 1 -C 6 )alkyl, or —(C 3 -C 8 )cycloalkyl; Q is a covalent bond, —C(O)—, or —SO 2 —; HET is a piperaziny, optionally substituted with: (A) one to four —(C 1 -C 6 )alkyl, optionally substituted with one to six halogen atoms, —(C 1 -C 6 )alkoxy, cyano, halogen, hydroxy, or —NR a R b , or (B) —(C 1 -C 6 )arylalkyl, optionally substituted with one to six halogen atoms, —(C 1 -C 6 )alkoxy, cyano, halogen, hydroxy, or —NR a R b ; n is 0 or 1; when n is 0, X is —CH 2 —, and Y is —CH 2 —, —CHF—, or —CF 2 —; or when n is 1, X is —CH 2 —, —CHF—, or —CF 2 —; and Y is —CH 2 —, —CHF—, or —CF 2 —, provided that X and Y are not both —CH 2 —; and Z is hydrogen or cyano.