Patent ID: 8557796

Claim:
A substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compound corresponding to formula I wherein R 1 and R 2 independently of one another represent H, C 1-18 -alkyl, C 3-10 -cycloalkyl, (C 1-12 -alkyl)-C 3-10 -cycloalkyl, aryl, (C 1-12 -alkyl)-aryl, heterocyclyl, (C 1-12 -alkyl)-heterocyclyl or NH—C(═O)-aryl, wherein at least one of the radicals R 1 and R 2 does not represent H, or together represent —(CR 4 R 5 ) m —(CR 6 R 7 ) n —Y—(CR 8 R 9 ) p —(CR 10 R 11 ) q — where m, n, p and q respectively=0, 1, 2, 3, 4 or 5, with the proviso that m+n≧1 and p+q≧1, or —CH 2 —CH 2 —C(-aryl)=CH—CH 2 —; R 3 represents SO 2 R 12 ; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 independently of one another represent H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or C(═O)R 14 ; Y represents CR 15 R 16 , NR 17 or O; R 12 represents C 1-10 -alkyl, C 3-10 -cycloalkyl, (C 1-6 -alkyl)-C 3-10 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or NR 18 R 19 ; R 14 represents H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or OR 20 ; R 15 and R 16 independently of one another represent H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or C(═O)R 21 ; R 17 represents H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or C(═O)R 22 ; R 18 and R 19 independently of one another represent H, C 1-10 -alkyl, C 3-8 -cycloalkyl, C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl or (C 1-6 -alkyl)-heterocyclyl; R 20 represents H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl or (C 1-6 -alkyl)-heterocyclyl; R 21 represents H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or OR 23 ; R 22 represents H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl, (C 1-6 -alkyl)-heterocyclyl or OR 24 ; and R 23 and R 24 independently of one another represent H, C 1-10 -alkyl, C 3-8 -cycloalkyl, (C 1-6 -alkyl)-C 3-8 -cycloalkyl, aryl, (C 1-6 -alkyl)-aryl, heterocyclyl or (C 1-6 -alkyl)-heterocyclyl, or a salt thereof with a physiologically tolerated acid.