Patent ID: 7482458

Claim:
A compound of formula (I): in which: Ar is an optionally substituted phenyl group, or a naphthyl or C 5-7 cycloalkdienyl group, or an optionally substituted single or fused ring heterocyclic group, having aromatic character, containing from 5 to 12 ring atoms and comprising up to four hetero-atoms in the or each ring selected from S, O, N; R is linear or branched C 1-8 alkyl, C 3-7 cycloalkyl, C 4-7 cycloalkylalkyl, an optionally substituted phenyl group or a phenyl C 1-6 alkyl group, an optionally substituted five-membered heteroaromatic ring comprising up to four heteroatoms selected from O and N, hydroxy C 1-6 alkyl, amino C 1-6 alkyl, C 1-6 alkylaminoalkyl, di C 1-6 alkylaminoalkyl, C 1-6 acylaminoalkyl, C 1-6 alkoxyalkyl, C 1-6 alkylcarbonyl, carboxy, C 1-6 alkoxyxcarbonyl, C 1-6 alkoxycarbonyl C 1-6 alkyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di C 1-6 alkylaminocarbonyl, halogeno C 1-6 alkyl; or is a group —(CH 2 ) p — when cyclized onto Ar, where p is 2 or 3; R 1 and R 2 , which may be the same or different, are independently hydrogen or C 1-6 linear or branched alkyl, or together form a —(CH2)n— group in which n represents 3, 4, or 5; or R 1 together with R forms a group —(CH 2 ) q —, in which q is 2, 3, 4 or 5; R 3 and R 4 , which may be the same or different are independently hydrogen, C 1-6 linear or branched alkyl, C 1-6 alkenyl, aryl, C 1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C 1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido, amino, mono- and di-C 1-6 alkylamino, —O(CH 2 ) r —NT 2 , in which r is 2, 3, or 4 and T is hydrogen or C 1-6 alkyl or it forms with the adjacent nitrogen a group in which V and V 1 are independently hydrogen or oxygen and u is 0, 1 or 2; —O(CH 2 ) s —OW 2 in which s is 2, 3, or 4 and W is hydrogen or C 1-6 alkyl; hydroxyalkyl, aminoalkyl, mono-or di-alkylaminoalkyl, acylamino, alkylsulphonylamino, aminoacylamino, mono- or di-alkylaminoacylamino; with up to four R 3 substituents being present in the quinoline nucleus; or R 4 is a group —(CH 2 ) t — when cyclized onto R 5 as aryl, in which t is 1, 2, or 3; R 5 is branched or linear C 1-6 alkyl, C 3-7 cycloalkyl, C 4-7 cycloalkylalkyl, optionally substituted aryl, wherein the optional substituent is one of hydroxy, halogen, C 1-6 alkoxy or C 1-6 alkyl, or an optionally substituted single or fused ring heterocyclic group, having aromatic character, containing from 5 to 12 ring atoms and comprising up to four hetero-atoms in the or each ring selected from S, O, N; X is O, S, or N—C≡N, or a pharmaceutically acceptable salt thereof.