Patent ID: 8318817

Claim:
A method of treating an otic infection or inflammation comprising intratympanically administering to an individual in need thereof a composition comprising a therapeutically effective amount of a multiparticulate antimicrobial agent, the composition further comprising (i) a-copolymer of polyoxyethylene and polyoxypropylene in an amount sufficient to provide a non-gelation viscosity that allows injection with a 18-31 gauge needle through the tympanic membrane into the ear, a gelation viscosity between about 15,000 cP and about 1,000,000 cP and a gelation temperature of between about room temperature and about body temperature; and (ii) having an osmolarity of less than 1000 mOsm/L; wherein the composition is a liquid at about room temperature and is administered at or about room temperature, and provides a sustained release of the antimicrobial agent in the ear for a period of at least 5 days after a single intratympanic administration.