Patent ID: 8329179

Claim:
A method for inducing apoptosis of a DR4-expressing cell, comprising contacting said cell with an agonist antibody or fragment thereof that specifically binds to a polypeptide consisting of amino acids 24 to 238 of SEQ ID NO:2 in combination with a second agent selected from the group consisting of: (a) an alkylating agent; (b) an antimetabolite; (c) a farnesyl transferase inhibitor; (d) a mitotic spindle inhibitor; (e) a topoisomerase inhibitor; (f) a tyrosine kinase inhibitor; (g) a proteasome inhibitor; (h) an antibiotic; (i) a histone deacetylase inhibitor; (j) a HSP90 inhibitor; (k) thalidomide; (l) a thalidomide analog; (m) a monoclonal antibody; (n) radiation therapy; (o) a AKT/mTOR signaling pathway inhibitor; and (p) a BCL-2 inhibitor.