Patent ID: 8367070

Claim:
An isolated protein comprising: (A) one or more conserved regions of an NhhA polypeptide which one or more conserved regions respectively consist of any of the following amino acid sequences selected from the group consisting of: (i) residues 1 to 50 of SEQ ID NO:11; (ii) residues 109 to120 of SEQ ID NO:11; (iii) residues 135 to198 of SEQ ID NO:11; (iv) residues 221 to 239 of SEQ ID NO:11; and (v) residues 249 to 604 of SEQ ID NO:11; and (B) one or more variable regions of an NhhA polypeptide, the one or more variable regions respectively consisting of any of the following amino acid sequences selected from the group consisting of: (a) residues 121 to134 of SEQ ID NO:11; (b) residues 199 to 220 of SEQ ID NO:11; and (c) residues 240 to 248 of SEQ ID NO:11; wherein a variable region of residues 51-108 of SEQ ID NO:11 or a fragment consisting of at least six amino acids thereof is absent; wherein the isolated protein is capable of eliciting an immune response against a plurality of strains of Neisseria meningitidis .