Patent ID: 7307097

Claim:
A compound of Formula (I): wherein: A is C 3 -C 7 cycloalkyl, aryl or heteroaryl, wherein said, C 3 -C 7 cycloalkyl, aryl and heteroaryl is substituted with at least one independently selected R 2 group, and optionally further substituted; D is C 1 -C 6 alkyl, aryl, heteroaryl, heterocyclyl, —RR 3 , —C(O)OR 4 , —C(O)NR 5 R 6 , or —C(O)R 4 , which alkyl, aryl, heteroaryl, and heterocyclyl may optionally be substituted; R is independently selected from C 1 -C 6 alkylene, C 2 -C 6 alkenylene, or C 2 -C 6 alkynylene, which alkylene, alkenylene, and alkynylene may optionally be substituted; R 1 is independently selected from hydrogen, C 1 -C 6 alkyl, aryl, —RR 3 , —C(O)OR 4 , —C(O)NR 5 R 6 , and —C(O)R 4 , which alkyl, and aryl may optionally be substituted; R 2 is independently selected from —NR′″C(O)NR′″R″″, —NR′″—C(═N—CN)—NR′″R″″or the structure: R 3 is independently selected from hydrogen, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 3 -C 7 cycloalkoxy, C 1 -C 6 haloalkoxy, aryl, aralkyl, aryloxy, heteroaryl, heterocyclyl, —CN, —NHC(O)R 4 , —NHC(S)R 4 , —NR 5 R 6 , —RNR 5 R 6 , —SR 4 , —S(O)R 4 , —S(O) 2 R 4 , —RC(O)OR 4 , —C(O)OR 4 , —C(O)R 4 , —C(O)NR 5 R 6 , —NHS(O) 2 R 4 , —S(O) 2 NR 5 R 6 , or —NHC(═NH)R 4 , which alkyl, haloalkyl, cycloalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryl, aralkyl, aryloxy, heteroaryl and heterocyclyl may optionally be substituted; R 4 is independently selected from hydrogen, C 1 -C 6 alkyl, aryl, heteroaryl, heterocyclyl, —RR 3 , —NR′″R″″, or —NR′NR′″R″″, which alkyl, aryl, heteroaryl, and heterocyclyl may optionally be substituted; R 5 is independently selected from hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, cyanoalkyl, —R′R″, aryl, aralkyl, heteroaryl, —NHC(O)OR′″, —R′NHC(O)OR′″, —R′NHC(O)NR′″R″″, or —R′C(O)OR′″, which alkyl, cycloalkyl, cyanoalkyl, aryl, aralkyl, and heteroaryl may optionally be substituted; R 6 is independently selected from hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, cyanoalkyl, —R′R″, aryl, aralkyl, heteroaryl, —C(O)OR′″, or —R′C(O)NR′″R′″, which alkyl, cycloalkyl, cyanoalkyl, aryl, aralkyl, and heteroaryl may optionally be substituted; R′ is independently selected from optionally substituted C 1 -C 4 alkylene; R″ is independently selected from optionally substituted heteroalkyl or NR′″R″″; R′″ is independently selected from hydrogen, C 1 -C 6 alkyl, aryl, aralkyl, heteroaryl, or C 3 -C 7 cycloalkyl, which alkyl, aryl, aralkyl, heteroaryl, and cycloalkyl may optionally be substituted; and R″″ is independently selected from hydrogen, C 1 -C 6 alkyl, aryl, heteroaryl, or C 3 -C 7 cycloalkyl, which alkyl, aryl, heteroaryl, and cycloalkyl may optionally be substituted; or a salt, solvate, or physiologically functional derivative thereof.