Patent ID: 7705034

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: A is a pyrrolyl or thienyl ring; R 1 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) nitro, (4) cyano, (5) amino, (6) C 1-6 alkyl, (7) heteroalkyl, (8) C 3-7 cycloalkyl, (9) C 2-6 alkenyl, (10) C 2-6 alkynyl, (11) hydroxy, (12) C 1-6 alkoxy, (13) —NR′R″, —(C 0-6 alkylene)-NR′R″, in which R′ and R″ are independently selected from the group consisting of: (a) hydrogen, (b) C 1-6 alkyl, (c) heteroalkyl, (d) formyl, (e) C 1-6 alkylcarbonyl, (f) optionally substituted C 3-7 cycloalkylcarbonyl, (g) optionally substituted arylcarbonyl, (h) optionally substituted heteroarylcarbonyl, (i) optionally substituted heterocyclylcarbonyl, (j) C 1-6 alkylsulfonyl, (k) optionally substituted C 3-7 cycloalkylsulfonyl, (l) optionally substituted arylsulfonyl, (m) optionally substituted heteroarylsulfonyl and (n) optionally substituted heterocyclylsulfonyl, (14) —(C 0-6 alkylene)-OR′, in which R′ is selected from the group consisting of hydrogen, C 1-6 alkyl, heteroalkyl, formyl and C 1-6 alkylcarbonyl; R 2 , R 2′ and R 2″ are independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) cyano, (4) nitro, (5) amino, (6) mono- or di-C 1-6 alkyl substituted amino, (7) C 1-6 alkyl, (8) C 2-6 alkenyl, (9) C 2-6 alkynyl, (10) heteroalkyl, (11) hydroxy, and (12) C 1-6 alkoxy; R 3 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) cyano, (4) nitro, (5) amino, (6) mono- or di-C 1-6 alkyl substituted amino, (7) C 1-6 alkyl, (8) C 2-6 alkenyl, (9) C 2-6 alkynyl, (10) heteroalkyl, (11) hydroxy, (12) C 1-6 alkoxy, (13) optionally substituted C 3-7 cycloalkyl, (14) optionally substituted aryl, (15) optionally substituted heteroaryl, (16) optionally substituted heterocyclyl, (17) optionally substituted C 3-7 cycloalkyl C 1-6 alkyl, (18) optionally substituted aryl C 1-6 alkyl, (19) optionally substituted heteroaryl C 1-6 alkyl, and (20) optionally substituted heterocyclyl C 1-6 alkyl; R 4 and R 5 , together with the carbon atom to which they are attached, form an optionally substituted C 3-7 cycloalkyl ring or an optionally substituted heterocyclyl ring; or alternatively, R 5 is hydrogen, halogen or C 1-6 alkyl, and R 4 is selected from the group consisting of: (1) hydrogen, (2) halogen, (3) cyano, (4) nitro, (5) amino, (6) mono- or di-C 1-6 alkyl substituted amino, (7) C 1-6 alkyl, (8) C 2-6 alkenyl, (9) C 2-6 alkynyl, (10) heteroalkyl, (11) hydroxy, (12) C 1-6 alkoxy, (13) optionally substituted C 3-7 cycloalkyl, (14) optionally substituted aryl, (15) optionally substituted heteroaryl, (16) optionally substituted heterocyclyl, (17) optionally substituted C 3-7 cycloalkyl C 1-6 alkyl, (18) optionally substituted aryl C 1-6 alkyl, (19) optionally substituted heteroaryl C 1-6 alkyl, and (20) optionally substituted heterocyclyl C 1-6 alkyl.