Patent ID: 8063242

Claim:
A method for the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, idiopathic fibrosis, glomerulonephritis and for the treatment of damage caused by ischemia and reperfusion, which comprises: administering to a patient in need thereof an effective amount of a (R,S)-2-aryl-propionic acid compound of formula (I), or the single (R) or (S) enantiomer: or a pharmaceutically acceptable salt thereof, wherein Ar is a phenyl ring substituted by: a group in the 3 (meta) position selected from a linear or branched C 1 -C 5 alkyl, C 2 -C 5 -alkenyl or C 2 -C 5 -alkynyl group optionally substituted by C 1 -C 5 -alkoxycarbonyl, substituted or not-substituted phenyl, linear or branched C 1 -C 5 hydroxyalkyl, aryl-hydroxymethyl, or a group in the 3 (meta) position selected from a linear or branched C 1 -C 5 alkyl group, optionally substituted by C 1 -C 5 -alkoxycarbonyl, substituted or not-substituted phenyl, linear or branched C 1 -C 5 hydroxyalkyl, aryl-hydroxymethyl, together with a substituent in the ortho or para position that comprises a benzene ring or a saturated or unsaturated, substituted or non-substituted bicycloaryl group; or a group in the 4 (para) position selected from C 1 -C 5 -acyloxy, substituted or not-substituted benzoyloxy, C 1 -C 5 -acylamino, substituted or not-substituted benzoylamino, C 1 -C 5 -sulfonyloxy, substituted or not-substituted benzenesulfonyloxy, C 1 -C 5 -alkanesulfonylamino, substituted or not-substituted benzenesulfonylamino, C 1 -C 5 -alkanesulfonylmethyl, substituted or not-substituted benzenesulfonylmethyl, C 3 -C 6 -cycloalkyl, 2-furyl, 3-tetrahydrofuryl, 2-thiophenyl, 2-tetrahydrothiophenyl, C 1 -C 8 (alkanoyl)-C 1 -C 5 -alkylamino, C 1 -C 8 (cycloalkanoyl)-C 1 -C 5 -alkylamino or C 1 -C 8 (arylalkanoyl)-C 1 -C 5 -alkylamino; or a group in the 2 (ortho) position selected from substituted or not-substituted arylmethyl, substituted or not-substituted aryloxy, or substituted or not-substituted arylamino, wherein the substituents of the aryl group are selected from C 1 -C 4 alkyl, C 1 -C 4 -alkoxy, chlorine, fluorine and/or trifluoromethyl groups, with the exception of (R,S)-2-(2′-benzylphenyl)-propionic acid.