Patent ID: 7608699

Claim:
An isolated polynucleotide comprising a nucleic acid encoding a lentiviral nuclear localization signal derived from a fragment of an HIV-1 integrase consisting of the amino acid sequence corresponding to the formula: R 5 (R 6 ) 2 FRVYR 1 R 3 R 2 R 8 R 3 NPLWR 3 GPR 8 KR 4 R 5 WR 3 GEGA(R 4 ) 3 R 6 DR 6 SR 6 R 4 KVR 4 PR(R 3 ) 2 R 8 KIR 4 R 3 D, wherein: R 1 =an aromatic amino acid; R 2 =an acidic amino acid; R 3 =a basic amino acid; R 4 =a branched chain amino acid; R 5 =a hydrophobic amino acid; R 6 =a polar amino acid; R 7 =a proline or serine amino acid residue; R 8 =a small amino acid residue selected from the group consisting of a glycine, an alanine, a cysteine and an asparagine amino acid residue.