Patent ID: 8431337

Claim:
An apparatus for detecting nucleic acid fragment-bonded beads translocated through nanopores, the apparatus comprising: a nanopore detection unit comprising (a) a solid substrate having nanopores of the size allowing nucleic acids to be translocated through, (b) electrodes applying a voltage to the nanopores of the solid substrate, and (c) single stranded nucleic acid probes having a first end attached to the solid substrate in an area surrounding the nanopore and a second end to which beads are attached, wherein each single stranded nucleic acid probe has an artificial sequence cleavable by a specific enzyme within the sequence complementary to a target nucleic acid, and wherein the beads have a diameter from 1 nm to 10 nm in size and are translocatable through nanopore; a sample storage chamber for storing the sample containing the target nucleic acids to be added to the nanopore detection unit; and an enzyme storage chamber for keeping the specific enzyme to be added to the nanopore detection unit.