Patent ID: 8633168

Claim:
A compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein: W is N or CR 10 ; X is N or CR 10 ; Y is NHR 1 ; Z is H, F, Cl, OR 1 , CF 3 , or optionally substituted alkyl; R 1 is, independently at each occurrence, H, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, or alkoxyacyl, wherein each acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, or alkoxyacyl is substituted or unsubstituted; R 2 is, independently at each occurrence, H, substituted or unsubstituted acyl, or substituted or unsubstituted alkyl; R 3 and R 4 are each independently H, F, Cl, CN, or COOR, where R is H or C1-C8 alkyl; or R 3 and R 4 taken together form a bond; R 5 is H, acyl, alkyl, alkenyl, alkynyl, amino, alkoxy, or alkoxyacyl, wherein each acyl, alkyl, alkenyl, alkynyl, amino, alkoxy, or alkoxyacyl is substituted or unsubstituted; R 6 and R 8 are each independently H, OH, F, alkoxy, or alkyl, wherein each alkoxy, or alkyl is substituted or unsubstituted; R 7 is OH, F, alkoxy, or alkyl, wherein each alkoxy or alkyl is substituted or unsubstituted; R 9 is OH, F, alkoxy, or alkyl, wherein each alkoxy or alkyl is substituted or unsubstituted; or R 9 is H when R 8 is F; and R 10 is, independently at each occurrence, H, CN, CF 3 , alkyl, alkenyl, alkynyl, or acyl, wherein each alkyl, alkenyl, alkynyl, or acyl is substituted or unsubstituted; provided that R 7 and R 9 are not both OH when W is CH, X is N, and Z is H.