Patent ID: 7589178

Claim:
A chimeric thrombin-cleavable derivative of a serine protease zymogen selected from the group consisting of protein C and factor X, wherein the native activation peptide of said zymogen is replaced with fibrinopeptide A, or a portion thereof, said replacement generates a thrombin-cleavable sequence P 10 P 9 P 8 P 7 P 6 P 5 P 4 P 3 P 2 P 1 P 1 ′P 2 ′P 3 ′ (SEQ ID NO:32), comprising amino acids P 10 to P 1 of fibrinopeptide A (SEQ ID NO:2) and amino acids P 1 ′-P 2 ′-P 3 ′ of a native cleavage site for thrombin of the protein C, wherein the amino acids P 1 ′-P 2 ′-P 3 ′ are represented by Leu-Ile-Asp, or the factor X, wherein the amino acids P 1 ′-P 2 ′-P 3 ′ are represented by Ile-Val-Gly.