Patent ID: 7105492

Claim:
A compound of formula (I) wherein: R 1 is a —C(R 5 )═N—O (n) R 4 group, wherein R 4 is hydrogen or a C 1 –C 8 linear or branched alkyl or C 1 –C 8 linear or branched alkenyl group or C 3 –C 10 cycloalkyl, or (C 3 –C 10 ) cycloalkyl-(C 1 –C 8 ) linear or branched alkyl group, or C 6 –C 14 aryl, or (C 6 –C 14 )aryl-(C 1 –C 8 ) linear or branched alkyl group, or a heterocyclic or heterocyclo-(C 1 –C 8 ) linear or branched alkyl group, said heterocyclic group containing at least a heteroatom selected from the group consisting of nitrogen atom, optionally substituted with a (C 1 –C 8 ) alkyl group, and/or oxygen and/or sulfur; said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aryl-alkyl, heterocyclic or heterocyclo-alkyl groups, being optionally substituted with one or more groups selected from the group consisting of: halogen, hydroxy, keto, C 1 –C 8 alkyl, C 1 –C 8 alkoxy, phenyl, cyano, nitro, —NR 6 R 7 , wherein R 6 and R 7 , the same or different between them, are hydrogen, (C i–C 8 ) linear or branched alkyl; the —COOH group or a pharmaceutically acceptable ester thereof; or the —CONR 8 R 9 group, wherein R 8 and R 9 , the same or different between them, are hydrogen, (C 1 –C 8 ) linear or branched alkyl, phenyl; or R 4 is a (C 6 –C 10 ) aroyl or (C 6 –C 10 ) arylsulfonyl group, optionally substituted with one or more groups selected from the group consisting of: halogen, hydroxy, C 1 –C 8 linear or branched alkyl, C 1 –C 8 linear or branched alkoxy, phenyl, cyano, nitro, —NR 10 R 11 , wherein R 10 and R 11 , the same or different between them are hydrogen, C 1 –C 8 linear or branched alkyl; R 4 is a polyaminoalkyl group; or R 4 is a glycosyl group; when the term n below is 0, the group —C(R 5 )═N is an enamine; n is the number 0 or 1; R 5 is hydrogen, C 1 –C 8 linear or branched alkyl, C 1 –C 8 linear or branched alkenyl, C 3 –C 10 cycloalkyl, (C 3 –C 10 )cycloalkyl-(C 1 –C 8 ) linear or branched alkyl, C 6 –C 14 aryl, (C 6 –C 14 )aryl-(C 1 –C 8 ) linear or branched alkyl; R 2 and R 3 , the same or different between them are hydrogen, hydroxy, C 1 –C 8 linear or branched alkoxy; their N 1 -oxides, their single isomers, in particular the syn and anti isomers of the —C(R 5 )═N—O (n) R 4 group, their possible enantiomers, diastereoisomers and relative admixtures, the pharmaceutically acceptable salts thereof and their active metabolites; with the proviso that when R 5 , R 2 and R 3 are hydrogen and n is 1, then R 4 is different from hydrogen.