Patent ID: 8268980

Claim:
An oligomeric compound having the formula: G-[T a -L] j -[R-L] q -R-[L-T b ] r -E wherein: each T a or each T b is a monomer of formula II: wherein independently for each monomer of formula II: Bx is a heterocyclic base moiety; Z is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl, substituted C 2 -C 6 alkynyl or substituted acyl; the other of each T a or each T b is a modified nucleoside wherein each modified nucleoside independently comprises a 2′-F modified sugar moiety, a 2′-OCH 3 modified sugar moiety, a 2′-O—(CH 2 ) 2 , —OCH 3 modified sugar moiety, a 2′-O—CH 2 -4′ bicyclic modified sugar moiety or a 4′-S modified sugar moiety; each R is a β-D-2′-deoxyribonucleoside; each L is an internucleoside linking group; G and E are each, independently, H, a hydroxyl protecting group or a linked conjugate group; wherein each substituted group is mono or poly substituted with substituent groups independently selected from halogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, OJ 1 , SJ 1 , NJ 1 J 2 , N 3 , COOJ 1 , CN, O—C(═O)—NJ 1 J 2 , N(H)C(═NH)NR 1 R 2 or N(H)C(═X)N(H)J 2 wherein X is O or S; each J 1 and J 2 is, independently, H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, C 1 -C 6 aminoalkyl, substituted C 1 -C 6 aminoalkyl or a protecting group; q is from 7 to about 15; j is from 1 to about 5; and r is from 1 to about 5.