Patent ID: 7737143

Claim:
A compound of formula (I) wherein: D is a heterocyclic ring selected from: where X 1 , X 2 , X 3 , X 4 are optionally substituted carbon, or one of X 1 , X 2 , X 3 , X 4 is nitrogen and the rest optionally substituted carbon; R 2 is 0-3 substituents independently selected from the group consisting of halogen, C 1-4 alkyl, CF 3 , OCF 3 , OCHF 2 , CN, aryl, hetaryl, C 1-4 alkylOH, C 1-4 alkylNR 3 R 4 , C 1-4 alkylhetaryl, OC 1-4 alkyl, OC 1-4 alkylNR 3 R 4 , OC 1-4 alkylhetaryl, OC 1-4 alkylOH, CO 2 R 3 , CONR 3 R 4 , NR 3 R 4 , nitro, NR 3 COR 4 , NR 5 CONR 3 R 4 , NR 3 SO 2 R 4 , C 1-4 alkylNR 3 COR 4 , C 1-4 alkylNR 5 CONR 3 R 4 and C 1-4 alkylNR 3 SO 2 R 4 ; R 3 and R 4 are each independently H, C 1-4 alkyl, C 1-4 alkylOH, C 1-4 alkylNR 19 R 20 , C 1-4 alkyl cycloalkyl, C 3-8 cyclohetalkyl, aryl, C 1-4 alkylaryl, hetaryl, or C 1-4 alkylhetaryl, or may be joined to form an optionally substituted 3-8 membered (saturated or unsaturated) ring optionally containing an atom selected from O, S and NR 6 ; and R 5 is H, C 1-4 alkyl, aryl or hetaryl; R 6 is selected from the group consisting of H, C 1-4 alkyl, C 1-4 alkylNR 19 R 20 , aryl, hetaryl, C 1-4 alkyl aryl and C 1-4 alkyl hetaryl; R 19 and R 20 are each independently H or C 1-4 alkyl; R 1 is H, C 1-4 alkyl, C 3-6 cycloalkyl, or may form a 5-8 membered ring onto the ortho position of ring A; A is aryl or hetaryl optionally substituted with 0-3 substituents independently selected from the group consisting of halogen, C 1-4 alkyl, CF 3 , OCF 3 , CN, NR 8 R 9 , aryl, hetaryl, C 1-4 alkylNR 8 R 9 , OC 1-4 alkylNR 8 R 9 , nitro, NR 10 C 1-4 NR 8 R 9 , NR 8 COR 9 , NR 10 CONR 8 R 9 , NR 8 SO 2 R 9 , CONR 8 R 9 and CO 2 R 8 ; R 8 and R 9 are each independently H, C 1-4 alkyl, aryl or together form an optionally substituted 4-8 membered ring which may contain a heteroatom selected from O, S and NR 11 ; R 10 is H or C 1-4 alkyl; R 11 is H or C 1-4 alkyl; and either Q is C 1-4 alkylene; and W is H, C 1-4 alkyl, or C 2-6 alkenyl or may form a 5-8 membered ring onto the ortho position of ring A; where C 1-4 alkyl or C 2-6 alkenyl may be optionally substituted with C 1-4 alkyl, OH, OC 1-4 alkyl or NR 12 R 13 ; R 12 and R 13 are each independently H, C 1-4 alkyl, or may be joined to form an optionally substituted 3-8 membered ring optionally containing an atom selected from O, S and NR 14 ; R 14 is H or C 1-4 alkyl; or Q and W are absent; Y is 0-2 substituents selected from H, C 1-4 alkyl, NR 15 R 16 ; R 15 and R 16 are independently H or C 1-4 alkyl; and pharmaceutically acceptable salts or diastereomers thereof; or a compound selected from a group consisting of: and pharmaceutically acceptable salts, or diastereomers thereof; or a compound selected from: or a pharmaceutically acceptable salt, or diastereomer thereof.