Patent ID: 7456156

Claim:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein: Z and Z′ are independently —O—, —NH— or —S—; Ar is a substituted or unsubstituted aryl group; X is an electron withdrawing group; R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups; Y is —H, an amine, —[NH—(CH 2 ) q ] r —NH 2 , halogen, —CF 3 , thiol, ammonium, —OH, —COOH, —SO 3 H, —OSO 3 H or phosphonium group covalently bonded to the terminal position of R, provided that when Y is —H and R is a straight chained hydrocarbyl group, then R has from 1 to 30 carbon atoms, and provided that each —NH— in —[NH—(CH 2 ) q ] r —NH 2 is optionally N-alkylated or N,N-dialkylated and —NH 2 in —[NH—(CH 2 ) q ] r —NH 2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated; q is an integer from 2 to about 10; r is an integer from 1 to about 5; R 1 and R 1 ′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N + (R 1a )—]; and R 1a is —H, alkyl, substituted alkyl, phenyl or substituted phenyl.