Patent ID: 8158662

Claim:
A compound of Formula I: in which n is selected from 1, 2 and 3; Z is selected from C and S(O); each Y is independently selected from —CR 4 ═; wherein R 4 is selected from hydrogen, cyano, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 1 is selected from halo, cyano, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy and —C(O)OR 4 ; wherein R 4 is selected from hydrogen, cyano, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 2 is selected from C 6-10 aryl, and C 3-12 cycloalkyl; wherein any aryl or cycloalkyl of R 2 is optionally substituted with 1 to 5 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —C(O)NR 5 R 5 , —OR 5 , —OC(O)R 5 , —NR 5 R 6 , —C(O)R 5 and —NR 5 C(O)R 5 ; wherein: R 5 and R 6 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, C 6-10 aryl-C 0-4 alkyl, and C 3-12 cycloalkyl-C 0-4 alkyl; wherein any aryl or cycloalkyl of R 5 is optionally substituted with 1 to 4 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted-C 1-6 alkoxy; R 3 is selected from C 6-10 aryl, and C 3-12 cycloalkyl; wherein any aryl or cycloalkyl of R 3 is substituted with 1 to 5 radicals independently selected from halo, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —OXR 7 , —OXC(O)NR 7 R 8 ,—OXC (O)NR 7 XC(O)OR 8 , —OXC(O)NR 7 XOR 8 , —OXC(O)NR 7 XNR 7 R 8 , —OXC (O)NR 7 XS(O) 0-2 R 8 , —OXC(O)NR 7 XNR 7 C(O)R 8 , —OXC (O)NR 7 XC(O)XC(O)OR 8 , —OXC(O)NR 7 R 9 , —OXC(O)OR 7 , —OXOR 7 , —OXR 9 , —XR 9 , —OXC(O)R 9 , —OXS(O) 0-2 R 9 and —OXC(O)NR 7 CR 7 [C(O)R 8 ] 2 ; wherein: X is a selected from a bond and C 1-6 alkylene wherein any methylene of X can optionally be replaced with a divalent radical selected from C(O), NR 7 , S(O) 2 and O; R 7 and R 8 are independently selected from hydrogen, cyano, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 2-6 alkenyl and C 3-12 cycloalkyl-C 0-4 alkyl; R 9 is selected from C 6-10 aryl-C 0-4 alkyl and C 3-12 cycloalkyl-C 0-4 alkyl; wherein any alkyl of R 9 can have a hydrogen replaced with —C(O)OR 10 ; and any aryl or cycloalkyl of R 9 is optionally substituted with 1 to 4 radicals independently selected from halo, C 1-6 alkyl, C 3-12 cycloalkyl, halo-substituted-C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkoxy, —XC(O)OR 10 , —XC(O)R 10 , —XC (O)NR 10 R 10 , —XS(O) 0-2 NR 10 R 10 and —XS(O)O 0-2 R 10 ; wherein: R 10 is independently selected from hydrogen and C 1-6 alkyl; or a pharmaceutically acceptable salt or isomer thereof.