Patent ID: 6951878

Claim:
A compound of Formula 1 wherein A is together with the double bond in Formula 1 benzo[b]thiophenyl, or 4,5,6,7-tetrahydro-benzo[b]thiophenyl; R 1 is hydrogen, COR 5 , OR 6 , CF 3 , nitro, SO 3 H, PO(OH) 2 , C(═NH)NH 2 , NR 7 R 8 or selected from the following 5-membered heterocycles: and R 1 is attached to position 3 of said benzo[b]thiophenyl or 4,5,6,7-tetrahydro-benzo[b]thiophenyl; R 2 is COR 5 , nitro, cyano, SO 3 H, PO(OH) 2 , or C(═NH)NH 2 ; R 3 , R 16 and R 17 are independently hydrogen, C 1 -C 6 alkyl, arylC 1 -C 6 alkyl, oxo, C 1 -C 6 alkyloxycarbonyl, arylC 1 -C 6 alkyloxycarbonyl, arylC 1 -C 6 alkyloxy, arylC 1 -C 6 alkyloxyC 1 -C 6 alkyl, arylC 1 -C 6 alkylthio, arylC 1 -C 6 alkylthioC 1 -C 6 alkyl, arylC 1 -C 6 alkylaminoC 1 -C 6 alkyl, di(arylC 1 -C 6 alkyl)aminoC 1 -C 6 alkyl, arylC 1 -C 6 alkylcarbonyl, arylC 1 -C 6 alkylcarbonylC 1 -C 6 alkyl, arylcarboxyC 1 -C 6 alkyl, arylC 1 -C 6 alkylcarboxy, arylC 1 -C 6 alkylcarboxyC 1 -C 6 alkyl, arylC 1 -C 6 alkylcarbonylamino, arylC 1 -C 6 alkylcarbonyl-aminoC 1 -C 6 alkyl, wherein the alkyl and aryl groups are optionally substituted; R 4 is hydrogen, hydroxy, C 1 -C 6 alkyl, wherein the alkyl and aryl groups are optionally substituted; R 5 is hydroxy, C 1 -C 6 alkyloxy, C 1 -C 6 alkyl-oxyC 1 -C 6 alkyloxy, arylC 1 -C 6 alkyloxy; wherein the alkyl and aryl groups are optionally substituted; R 6 is hydrogen; wherein is attached to position 2 of said benzo[b]thiophenyl or 4,5,6,7-tetrahydro-benzo[b]thiophenyl, or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, racemic mixture, or any tautomeric forms.