Patent ID: 7541189

Claim:
An in vitro complex of a transcription coupling factor of any one of ARNT 1 to 3 and a transcription regulatory factor comprising any of the amino acid sequences shown below, which is a transcription activating complex that binds to a DNA region (5′-ACGTG-3′, SEQ ID NO: 16) in competition with a transcription inhibiting complex of a Sim2 as a transcription regulatory factor and a transcription coupling factor of any one of ARNT 1 to 3 and which promotes transcription of a gene located downstream of the DNA region, wherein the amino acid sequences are: (a) the amino acid sequence represented by any one of SEQ ID NOs: 1 to 3, (b) an amino acid sequence of a protein comprising an amino acid sequence exhibiting an amino acid identity of 90% or more to the amino acid sequence represented by any of SEQ ID NOs: 1 to 3 and regulates transcription of a gene located downstream of a DNA region comprising the nucleotide sequence of SEQ ID NO:16.