Patent ID: 7629346

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: (a) R 1 is selected from the group consisting of: (1) cycloalkyl, which is optionally substituted by a substituent selected from the group consisting of hydroxy, lower alkoxy and lower hydroxyalkyl, (2) —CH 2 —(CR 9 R 10 ) m -cycloalkyl, wherein: (A) R 9 is selected from the group consisting of hydrogen, lower alkyl and cycloalkyl; (B) R 10 is selected from the group consisting of hydrogen, hydroxy and lower alkoxy; (C) m is 0 or 1, and (D) the cycloalkyl is optionally substituted by hydroxy or lower hydroxyalkyl, (3) piperidinyl, and (4) —CR 11 R 12 —COOR 13 ; wherein: (A) R 11 is hydrogen or lower alkyl, (B) R 12 is hydrogen or lower alkyl; and (C) R 13 is lower alkyl; (b) R 2 is hydrogen; (c) R 3 is —OR 14 , wherein R 14 is selected from the group consisting of: (1) lower alkyl, (2) lower halogenalkyl, (3) cycloalkyl, (4) lower cycloalkylalkyl, (5) lower heterocyclylalkyl, (6) lower heteroarylalkyl, (7) lower alkoxyalkyl, and (8) lower hydroxyalkyl; or R 3 is —NR 15 R 16 wherein either: (A) R 15 is hydrogen or lower alkyl, and R 16 is selected from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl, lower hydroxyalkyl and lower alkoxyalkyl; or (B) R 15 and R 16 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from the group consisting of acetidine, pyrrolidine, piperidine and azepane, wherein said heterocyclic ring is optionally substituted by alkoxy; (d) R 4 is hydrogen or halogen; (e) R 5 is selected from the group consisting of hydrogen, halogen, lower halogenalkyl, lower halogenalkoxy, and cyano; (f) R 6 is selected from the group consisting of hydrogen, halogen, lower halogenalkyl, lower halogenalkoxy, and cyano; (g) R 7 is selected from the group consisting of hydrogen, halogen, lower halogenalkyl, lower halogenalkoxy and cyano; and (h) R 8 is hydrogen or halogen.