Patent ID: 8383095

Claim:
A method of enhancing engraftment of an allogeneic hematopoietic stem cell (HSC) graft in a patient, comprising administering the HSC graft to said patient at a suboptimal dose in conjunction with an expanded allogeneic myeloid progenitor (MP) cell graft comprising common myeloid progenitor (CMP) cells, granulocyte/macrophage progenitor (GMP) cells, and megakaryocyte/erythroid progenitor (MEP) cells in an amount effective to enhance the engraftment of the hematopoietic stem cells, wherein the myeloid progenitor cell graft comprises a population of pooled, culture-expanded, myeloid progenitor cells from multiple unrelated donors, wherein the MP cell graft enhances engraftment of the HSC graft suboptimal dose, thereby enhancing engraftment of the HSC graft.