Patent ID: 8722618

Claim:
A binding protein comprising a binding domain, an amino terminal cap (N-cap) module and a carboxy terminal cap (C-cap) module, wherein the binding protein binds to human IL4 and inhibits human IL4 binding to IL4Ralpha in vitro or in vivo, and the binding domain is an ankyrin repeat domain and comprises an ankyrin repeat (AR1) module positioned C-terminal to the N-cap comprising the amino acid sequence of SEQ ID NOS: 39 or 88, an ankyrin repeat (AR2) module positioned C-terminal to the AR1 module comprising the amino acid sequence of SEQ ID NOS: 89 or 180, and an ankyrin repeat (AR3) module positioned C-terminal to the AR2 module comprising the amino acid sequence of SEQ ID NO: 181 and wherein the N-cap module is positioned N-terminal to the ankyrin repeat domain comprising the amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 171, and 174 and the C-cap module is positioned C-terminal to the ankyrin repeat domain comprising the amino acid sequence selected from the group consisting of SEQ ID NOS: 3, 103, 172, and 175.