Patent ID: 7704755

Claim:
A method for differentially forming a complex of a platinum compound and an entity or at least one entity of a mixture of two or more entities, the method comprising: forming a complex of a platinum compound and an entity, said entity comprising one or more sulphur-containing reactive sites and one or more nitrogen-containing reactive sites, wherein said platinum compound is reacted with said entity such that substantially only nitrogen containing reactive sites are linked to said platinum compound; or forming a complex of a platinum compound and at least one entity of a mixture of two or more entities, said at least one entity or said entities together comprising one or more sulphur-containing reactive sites and one or more nitrogen-containing reactive sites, wherein said platinum compound is reacted with said at least one entity or said entities together, such that substantially only nitrogen containing reactive sites are linked to said platinum compound, wherein said sulphur containing site or sites are first differentially shielded by a shielding moiety and thereafter said platinum compound is differentially linked to the one or more nitrogen containing reactive sites; wherein said entity or said entities are selected from the group consisting of amino acids, peptides, oligopeptides, polypeptides, proteins, immunoglobulins, enzymes, synzymes, phospholipids, glycoproteins, nucleic acids, nucleosides, nucleotides, oligonucleotides, polynucleotides, peptide nucleic acids, peptide nucleic acid oligomers, peptide nucleic acid polymers, amines and aminoglycosides; and wherein said shielding moiety is a trans-platinum compound.