Patent ID: 6972289

Claim:
A cell division inhibitor comprising, as an active ingredient, a compound of formula (II) or an E form thereof, or pharmaceutically acceptable salt thereof: wherein R 1 is hydrogen, halogen, C 1-25 alkyl, C 2-25 alkenyl, C 2-25 alkynyl, C 1-25 alkoxy, aralkyl, hydroxyl, amino, nitro or aryl, which may be substituted with other substituent(s), and a part of the carbon chain of R 1 may be branched or cyclized, or may comprise a heteroatom, and further R 1 may be one atom or group, or at most 5 identical or different atoms or groups, and the atoms or groups may mutually form a ring; R 2 is hydrogen, halogen, C 1-25 alkyl, C 2-25 alkenyl, C 2-25 alkynyl, C 1-25 alkoxy, aralkyl, hydroxyl, amino, nitro or aryl, which may be substituted with other substituent(s), and a part of the carbon chain of R 2 may be branched or cyclized, or may comprise a heteroatom; each of R 3 and R 4 is independently hydrogen, halogen, C 1-25 alkyl, C 2-25 alkenyl, C 2-25 alkynyl, C 1-25 alkoxy, aralkyl, hydroxyl, amino, nitro or aryl, which may be substituted with other substituent(s), and a part of the carbon chain may be branched or cyclized, or may comprise a heteroatom; R 5 is hydrogen, halogen, C 1-25 alkyl, C 2-25 alkenyl, C 2-25 alkynyl, C 1-25 alkoxy, aralkyl, hydroxyl, amino, nitro or aryl, which may be substituted with other substituent(s), and a part of the carbon chain of R 5 may be branched or cyclized, or may comprise a heteroatom; R 6 is hydrogen, halogen, C 1-25 alkyl, C 2-25 alkenyl, C 2-25 alkynyl, C 1-25 alkoxy, aralkyl, hydroxyl, amino, nitro or aryl, which may be substituted with other substituent(s), and a part of the carbon chain of R 6 may be branched or cyclized, or may comprise a heteroatom; each of R 7 and R 8 is independently hydrogen, halogen, C 1-25 alkyl, C 2-25 alkenyl, C 2-25 alkynyl, C 1-25 alkoxy, aralkyl, hydroxyl, amino, nitro or aryl, which may be substituted with other substituent(s), and a part of the carbon chain may be branched or cyclized, or may comprise a heteroatom; R 2 and R 3 may form a ring; R 4 and any of R 5 , R 6 , R 7 and R 8 may form a ring; the bond depicted by a solid line and dashed line represents a carbon—carbon single bond or a carbon—carbon double bond; at least one of said groups may have a protecting group capable of decomposing in vivo.