Patent ID: 8742161

Claim:
A process for producing a compound represented by the formula (I) or a salt thereof comprising: (in the formula (I), R 1 represents (1) —OH, (2) —O—R a , or (3) —NR b R c , R a represents a C 1-6 alkyl group or a C 3-8 cycloalkyl group (wherein the C 1-6 alkyl group or C 3-8 cycloalkyl group is either unsubstituted or substituted with one or more of a C 1-6 alkoxy group, a hydroxyl group, a halogen atom, an aryl group, or a heteroaryl group), R b and R c , which may be the same or different from each other, each represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group, or a C 3-8 cycloalkyl group (the C 1-6 alkyl group or C 3-8 cycloalkyl group is either unsubstituted or substituted with one or more of a hydroxyl group, a C 1-6 alkoxy group, an aryl group, or a heteroaryl group), or R b and R c may bond to each other and form a 4- to 7-membered saturated heterocycle together with an adjacent nitrogen atom (wherein the saturated heterocycle is either unsubstituted or substituted with a hydroxyl group, a C 1-6 alkyl group, or a C 1-6 alkoxy group)) (A) converting a compound represented by the formula (II) to a compound represented by the formula (III), wherein the compound represented by Formula (III) is produced by reacting the compound represented by Formula (II) with an acyl group donor in the presence of an enzyme derived from a microorganism or Fungus, (in the formula (II), R 1 is as defined in the formula (I) above) (in the formula (III), R 1 is as defined in the formula (I) above, R 2 represents a hydrogen atom, a C 1-6 alkyl group, a C 3-8 cycloalkyl group, or a —(CH 2 ) n -phenyl group (wherein the C 1-6 alkyl group, C 3-8 cycloalkyl group, or —(CH 2 ) n -phenyl group is either unsubstituted or substituted with one or more of a halogen atom, a hydroxyl group, a C 1-6 alkyl group, or a C 1-6 alkoxy group), and n represents 0, 1, or 2) (B) converting the compound represented by the formula (III) to a compound represented by the formula (IV), (in the formula (IV), R 1 and R 2 are as defined in the formula (I) and the formula (III) above), (C) converting the compound represented by the formula (IV) to a compound represented by the formula (V), (in the formula (V), R 1 is as defined in the formula (I) above), and (D) converting the compound represented by the formula (V) to the compound represented by the formula (I).