Patent ID: 7547794

Claim:
A pharmaceutical composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle, wherein: R 1 is Ar 1 ; R 2 is hydrogen; T is CH; A 1 is C-halogen, C—CN, or C—R; each of A 2 and A 3 is, independently, CR 4 ; R 4 is selected from halogen, NO 2 , CN, -(L) m R, -(L) m Ar 1 , or -(L) m Cy 1 ; or two R 4 groups on adjacent atoms are taken together to form an optionally substituted 5-7 membered partially unsaturated or fully unsaturated ring having 0-3 heteroatoms independently selected from oxygen, sulfur, or nitrogen, wherein each ring formed by two R 4 groups on adjacent atoms taken together is optionally substituted with up to 4 occurrences of Z—R X ; L is a C 1-6 alkylidene chain wherein one methylene unit of L is optionally replaced by —O—, —N(R)—, —N(R)C(O)—, —C(O)—, —C(O)N(R)—, —SO 2 N(R)—, or —N(R)SO 2 —; m is 0 or 1; Ar 1 is Cy 1 is selected from wherein; Ar 1 and Cy 1 are each optionally substituted with up to 5 occurrences of Z-R X ; wherein each occurrence of Z is independently a bond or a C 1-6 alkylidene chain, wherein up to two non-adjacent methylene units of Z are optionally replaced by —S—, —O—, —N(R)—, —N(R)C(O)—, —C(O)N(R)—, —SO 2 N(R)—, or —N(R)SO 2 —; each occurrence of R X is independently selected from —R′, halogen, NO 2 , CN, —OR′, —SR′, or —N(R′) 2 , each occurrence of R is independently hydrogen or a C 1-6 aliphatic group; and each occurrence of R′ is independently hydrogen, a C 1-6 aliphatic group, a C 6-10 aryl ring, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms; or R and R′ or two occurrences of either R or R′ are taken together with the atoms to which they are bound to form an optionally substituted 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or two occurrences of either R′ or R on the same nitrogen are taken together with the nitrogen atom to which they are bound to form an optionally substituted 5-8 membered saturated, partially unsaturated, or aryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur.