Patent ID: 7563868

Claim:
An isolated functional NRIF3 nuclear hormone receptor co-activator polypeptide (NRIF3 polypeptide), wherein the NRIF3 polypeptide binds in a ligand dependent manner to thyroid hormone receptor (TR) and retinoid X receptor (RXR), but does not interact with retinoic acid receptor (RAR), vitamin D receptor (VDR), progesterone receptor (PR), glucocorticoid receptor (GR), and estrogen receptor (ER) in a yeast two hybrid assay system or in vitro, or both, which polypeptide contains an LxxIL (SEQ ID NO:2) module in its C-terminal domain, and wherein the NRIF3 polypeptide exhibits at least about 85% identity to SEQ ID NO:4.