Patent ID: 7829548

Claim:
A method of treating HIV infection comprising administering to a patient in need thereof 2′,3′-dideoxy-3′-C-hydroxymethylcytidine or a prodrug thereof according to the formula: where one of R and R′ is a prodrug moiety with the partial structure: where R 1 is C 1 -C 18 straight or branched chain alkyl and R 2 is H; or R 1 is methyl and R 2 is NH-L-valyl or NH-L-isoleucyl; or R 1 is branched chain C 3 -C 4 alkyl and R 2 is NH 2 ; and the other one of R and R′ is H or an identical prodrug moiety; or a salt thereof, wherein the reverse transcriptase of the infecting HIV bears at least one of the following genotypic patterns: (a) M41, ±D67, L210 and T215; (b) D67, K70 and K219; (c) T69S-XX; or (d) ▴67 (deletion at 67), which mutation allows an obligate chain terminating nucleoside- or nucleotide-phosphate to be excised from a nascent DNA strand by ATP- or pyrophosphate-mediated excision.