Patent ID: 8518372

Claim:
A method of treating a mycobacterial infection caused by Mycobacterium tuberculosis , comprising administering an effective amount of a coronin 1 modulator to a patient in need thereof, wherein the coronin 1 modulator is selected from the group consisting of: an anti-coronin 1 polyclonal antibody, monoclonal antibody or an Fab fragment thereof; a humanized antibody comprising the binding portion of an anti-coronin 1 monoclonal antibody; a peptide comprising a coronin 1 peptide selected from (SEQ ID NO: 1) KSRELRVNRGLDTGRRR, (SEQ ID NO: 2) VSRLEEEMRKLQATVQELQKRLDRLEETVQAK, (SEQ ID NO: 3) MSRQVVRSSKFRHVFGQPAKADQCYE, (SEQ ID NO: 4) VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWE, (SEQ ID NO: 5) LEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWD, (SEQ ID NO: 6) PEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIE, (SEQ ID NO: 7) DRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWD, and (SEQ ID NO: 8) PLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYF; a phospho-peptide comprising a peptide of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, or 8, wherein one to five serine and/or threonine residues are phosphorylated; and an RNA selected from GUUCCGCCACGUGUUUGGA, (SEQ ID NO: 9) UCCAAACACGUGGCGGAAC, (SEQ ID NO: 10) GGCCGACCAGUGCUAUGAA, (SEQ ID NO: 11) UUCAUAGCACUGGUCGGCC, (SEQ ID NO: 12) GAUGUGCGCGUCUCACAGA, (SEQ ID NO: 13) UCUGUGAGACGCGCACAUC, (SEQ ID NO: 14) CCCUAAGUUUGUGGCCCUG, (SEQ ID NO: 15) CAGGGCCACAAACUUAGGG, (SEQ ID NO: 16) GUUUGUGGCCCUGAUCUGU, (SEQ ID NO: 17) and ACAGAUCAGGGCCACAAAC. (SEQ ID NO: 18)