Patent ID: 7560457

Claim:
A compound of the formula I: wherein: R 1 and R 2 are different, independent groups and are selected from the group consisting of OR 3 and N(R 3′ )(R 3″ ); or R 1 and R 2 are different, are connected through a single bond, and are selected from the group consisting of O and NR 3 ; R 3 , R 3′ , and R 3″ are independently selected from the group consisting of H, C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 8 cycloalkyl, substituted C 3 to C 8 cycloalkyl, C 6 to C 20 aryl, substituted C 6 to C 20 aryl, heteroaryl, and substituted heteroaryl; R 4 and R 4′ are: (a) independently selected from the group consisting of H, OH, O(C 1 to C 6 alkyl), O(substituted C 1 to C 6 alkyl), O(acyl), O(aryl), O(substituted aryl), and halogen; or (b) taken together to form a double bond to O; R 5 , R 6 , and R 7 are independently selected from the group consisting of H, OH, and OCH 3 ; R 8 and R 9 are connected through a double bond and are CH; R 15 is selected from the group consisting of C═O, CHOH, and CH 2 ; n is 1 or 2; wherein the acyl group is HC(O)— or a —C(O)R′″— group, wherein R′″ is selected from C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, and alkoxy; wherein the heteroaryl group consists of a monocyclic, saturated, partially saturated, or wholly unsaturated ring of 6-20 carbon atoms and one to four heteroatoms independently selected from N, S and O; wherein the substituents for the substituted C 1 to C 6 alkyl, C 6 to C 20 aryl, heteroaryl or acyl consist of one or more substituents independently selected from halogen, CN, OH, NO 2 , amino, C 6 to C 20 aryl, a heterocyclic ring consisting of a monocyclic, saturated, partially saturated, or wholly unsaturated 4- to 7-membered ring having 1 to 4 heteroatoms independently selected from N, S, and O, alkoxy, aryloxy, alkylcarbonyl, alkylcarboxy, and arylthio; or a pharmaceutically acceptable salt thereof.