Patent ID: 8741270

Claim:
A method for local delivery of a functional compound to skin comprising: contacting a compound having the formula D-B—F to skin; and subjecting the compound to an activating agent wherein the compound is cleaved so that a compound B—F is tethered to the skin; and wherein D is a naphthalimide compound having the following formula: which is a mixture of stereoisomers, wherein n is an integer from about 1 to about 20; R is selected from the group consisting of CH 3 , C 4 H 9 , C 6 H 13 , (CH 2 ) 2 N(CH 3 ) 3 +, CH 2 COOH, (CH) 2 CH 2 (CH 3 ) 2 COOH, and (CH) 2 CH 2 (CH 3 ) 2 COOCH 3 ; and R* is a bond between D and B, B is a biomolecule selected from the group consisting of chitosan, protein, hydrolyzed protein, and carbohydrates, and F is the functional compound comprising at least one of sulfonic acid functional groups, alcohol functional groups, and amine functional groups.