Patent ID: 8466117

Claim:
A method of reducing angiogenesis in a subject in need thereof, the method comprising contacting a cell with an effective amount of an antisense nucleic acid molecule complementary to at least a portion of a microRNA nucleic acid molecule of the mir-17-92 cluster, wherein the antisense nucleic acid molecule comprises a nucleobase sequence having at least 95% identity to a sequence selected from the group consisting of: (SEQ ID NO: 1) miR-17-5p: ACUACCUGCACuGUAAGCACUUUG; (SEQ ID NO: 2) mir-18a: UAUGUGCACUAGAUGCACCUUA; (SEQ ID NO: 3) mir-19a: UCAGUUUUGCAUAGAUUUGCACA; (SEQ ID NO: 4) mir-19b: UCAGUUUUGCAUGGAUUUGCACA; (SEQ ID NO: 5) mir-20a: CUACCUGCACUAUAAGCACUUUA; and (SEQ ID NO: 6) mir-92-1: CAGGCCGGGACAAGUGCAAUA. thereby reducing angiogenesis.