Patent ID: 8034839

Claim:
A method for the treatment of ocular allergy in a mammal, which comprises topically administering to the eye of the mammal a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of formula I: wherein R 1 is CONR 2 R 3 or CH 2 NR 5 R 6 , where: R 2 , R 3 are independently H, C 1-6 alkyl, C 3-6 cycloalkyl, benzyl, phenyl, OH, OCH 3 , or OC 2 H 5 , provided that at most only one of R 2 , R 3 is OH, OCH 3 , or OC 2 H 5 ; R 5 , R 6 are independently H, C(O)R 14 , C 1-6 alkyl, C 3-6 cycloalkyl, benzyl, phenyl, OH, OCH 3 , or OC 2 H 5 , provided that at most only one of R 2 , R 3 is OH, OCH 3 , or OC 2 H 5 ; R 7 , R 8 , and R 9 are independently H, CH 3 , C 2 H 5 , C(O)R 14 , or CO 2 R 15 ; or R 7 and R 8 or R 8 and R 9 together constitute a carbonyl group (C═O), thus forming a cyclic carbonate; or OR 8 R 1 together form a cyclic ester (a lactone); R 14 is H, C 1-6 alkyl, C 3-6 cycloalkyl, benzyl, or phenyl; R 15 is C 1-6 alkyl, C 3-6 cycloalkyl, benzyl, or phenyl; and indicates that the OR 9 substituent can be arranged to afford the R or S absolute configuration: