Patent ID: 7160915

Claim:
A compound of Formula Q is, —NH 2 , R 1 is hydrogen, C 1-6 alkyl, C 2-8 alkenyl, C 2-6 alkynyl, C 3 –C 12 cycloalkyl, —(CR 10 R 11 ) q (C 6 –C 10 aryl), or —(CR 10 R 11 ) q (4–10 membered heterocyclic); wherein said R 1 is optionally substituted with 1 to 3 substituents selected from the group consisting of —COOH, —COOR 14 , —COR 9 , —(CR 10 R 11 ) q (C 6 –C 10 aryl), —(CR 10 R 11 ) q (4–10 membered heterocyclic), —SO 2 R 11 , —SO 2 NR 12 R 13 , —OH, —OR 14 , cyano, halo, —NR 9 R 9a , and —NR 9 CO(R 11 ); R 2 is hydrogen, chlorine, fluorine or methyl; R 3 is C 1-6 alkyl; R 4 is bromine, chlorine, fluorine, iodine, C 1-6 alkyl, C 2-4 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, —(CH 2 )—C 3-6 cycloalkyl, cyano, —O—(C 1-4 alkyl), —S—(C 1-2 alkyl), —SOCH 3 , —SO 2 CH 3 , —SO 2 NR 6 R 7 , —C≡C—(CH 2 ) n NH 2 , —C≡C—(CH 2 ) n NHCH 3 , —C≡C—(CH 2 ) n N(CH 3 ) 2 , —C≡C—CH 2 OCH 3 , —C═C(CH 2 ) n OH, —C═C—(CH 2 ) n NH 2 , —CHCHCH 2 OCH 3 , —CHCH—(CH 2 ) n NHCH 3 , —CHCH—(CH 2 ) n N(CH 3 ) 2 , —(CH 2 ) p CO 2 R 6 , —C(O)C 1-3 alkyl, C(O)NHCH 3 , —(CH 2 ) m NH 2 , —(CH 2 ) m NHCH 3 , —(CH 2 ) m N(CH 3 ) 2 , —(CH 2 ) m OR 6 , —CH 2 S(CH 2 ) t (CH 3 ), —(CH 2 ) p CF 3 , —C≡CCF 3 , —CH═CHCF 3 , —CH 2 CHCF 2 , —CH═CF 2 , —(CF 2 ) v CF 3 , —CH 2 (CF 2 ) n CF 3 , —(CH 2 ) t CF(CF 3 ) 2 , —CH(CF 3 ) 2 , —CF 2 CF(CF 3 ) 2 , or —C(CF 3 ) 3 , wherein the C 1-6 alkyl and C 2-6 alkynyl are optionally substituted with 1 to 3 substituents independently selected from —OH and C 1-6 alkyl; R 5 is hydrogen or fluorine; R 6 and R 7 are each independently hydrogen, methyl, or ethyl; R 9 and R 9a are each independently hydrogen or C 1-6 alkyl; each R 10 , R 11 , R 12 , and R 13 are C 1-6 alkyl or C 1-6 alkoxy; R 14 is C 1-6 alkyl optionally optionally substituted with 1 to 3 substituents selected from the group consisting of —(CR 10 R 11 ) q (C 6 –C 10 aryl), —(CR 10 R 11 ) q (4–10 membered heterocyclic); m is 1 to 4; n is 1 to 2; p is 0 to 2; t is 0 to 1; v is 1 to 5; q is 0 to 5: and pharmaceutically acceptable salts thereof.