Patent ID: 6897306

Claim:
A compound of the formula formula: wherein: X is C 1-6 alkylene or C 2-6 alkenylene, each of which is optionally substituted by one or more fluorine atoms; R is aryl or C 3-8 cycloalkyl optionally substituted by one or more fluorine atoms; Y is represented by H, C 1-4 alkyl (optionally substituted by one or more substituents independently selected from halogen, S(O) p R 6 , OR 5 , CONR 1 R 2 , CO 2 R 7 and aryl-), C 1-4 alkanoyl optionally substituted by one or more halogen, C 1-4 alkoxycarbonyl optionally substituted by one or more halogen, or CONR 1 R 2 ; R 1 and R 2 are each independently selected from H, C 3-8 cycloalkyl, C 1-4 alkyl either of which may optionally be substituted by one or more substituents selected from C 3-8 cycloalkyl, aryl, CO 2 H, CO 2 R 5 and/or NR 3 R 4 , or R 1 and R 2 can be taken together with the nitrogen to which they are attached to represent a 4- to 6-membered heterocyclic ring optionally containing one or two further hetero atoms in the ring independently selected from N, O and S, which heterocyclic ring is optionally benzo- or pyrido-fused, and which heterocyclic ring is optionally substituted by one or more substituents selected from C 1-4 alkyl, CO 2 H, CO 2 R 5 , aryl and/or NR 3 R 4 ; R 3 and R 4 are each independently selected from H, C 1 -C 4 alkyl or C 1-4 alkoxycarbonyl, either of which may optionally substituted by one or more halogen, or R 3 and R 4 can be taken together with the nitrogen atom to which they are attached to represent a morpholine, piperidine, azetidine or piperazine (optionally N-substituted by C 1-4 alkyl) moiety; R 5 is C 1-4 alkyl optionally substituted by CO 2 R 7 or CONR 3 R 4 , or R 5 is aryl; R 6 is C 1-4 alkyl optionally substituted by one or more halogen, or R 6 is aryl; R 7 is H or R 5 ; p is 0, 1 or 2; L is suitable leaving group represented by a substituent selected from the group consisting of halide, C 1-4 halogen, alkylsulphonate, or arylsulphonate; and the pharmaceutically acceptable salts, solvates (including hydrates)L and prodrugs thereof.