Patent ID: 7851500

Claim:
A compound of the formula I wherein X is —O— or —S—; Y is —CH—; Z is —NH— or —O—; R 1 is H, C 1 -C 6 alkyl, C 1 -C 5 arylalkyl, C 3 -C 8 cycloalkyl, C 9 -C 14 bicycloalkyl, C 6 -C 10 aryl, C 5 -C 13 heteroaryl, C 4 -C 12 heterocyclyl and 3 to 8-membered heterocycloalkyl and each of said groups is optionally substituted with 1 to 3 groups selected from the group consisting of halogen, —OH, —C(═O)OR 3 , —S(═O)NHR 3 , —SO 2 NHR 3 , —SO 2 R 3 , alkyl, substituted alkyl, —CN, —NHR 3 , —CONHR 3 , —OCONHR 3 , —CONHSO 2 R 3 , —NHCONHR 3 , —CH 2 OR 3 , —CH 2 CH 2 OH, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl and substituted heteroaryl; R 2 is an optionally substituted aryl or heteroaryl group; said substituents on the substituted aryl or substituted heteroaryl group are selected from the group consisting of one or more hydrogen, halogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, hydroxy, halogen, amino, substituted amino, amide, substituted amide and carbamate; R 3 is hydrogen or C 1 -C 4 alkyl; C 3 -C 6 cycloalkyl, C 6 -C 10 aryl, substituted aryl, C 1 -C 5 arylalkyl, heteroaryl, heterocyclyl, aryloxy, substituted aryloxy, —CF 3 and —OCF 3 ; and R 4 is hydrogen, alkyl, substituted alkyl, hydroxy, cyano or halogen; or a pharmaceutically acceptable salt or stereoisomer thereof.