Patent ID: 7265140

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof wherein: X is —SO—, —SO 2 —, or —SONR 6 —; Z is —C—, —CH—, or —N—; each “ . . . ” is independently absent, or a bond; each W is independently —CHR 6 —, —CHR 6 CH 2 —, or absent; R 1 is (a) —NH 2 , (b) —NHC 1-4 alkyl, (c) —C 1-6 alkyl, optionally substituted with 1-3 halo, (d) —C 2-6 alkenyl, (e) —(CH 2 ) n C(═O)C 1-4 alkyl, (f) —OC 1-4 alkyl, (g) —SC 1-4 alkyl, or (h) —(CH 2 ) n C 3-7 cycloalkyl; R 2 and R 3 are independently —H, or —F; R 4 is —H, —C 1-4 alkyl, or —CO 2 R 6 ; R 5 is (a) —C 1-10 alkyl, (b) —C 3-7 cycloalkyl, (c) -aryl, (d) -het, (e) —OC 1-10 alkyl, (f) —O—C 3-7 cycloalkyl, (g) —O-aryl, (h) —O-het, (i) —C(R 6 )(R 7 )NH 2 , (j) —C(R 6 )(R 7 )NHCO 2 C 1-4 alkyl, (k) —C(R 6 )(R 7 )NHCOC(R 6 )(R 7 )NH 2 , or (l) —C(R 6 )(R 7 )NHCOC(R 6 )(R 7 )NHCO 2 C 1-4 alkyl; each R 6 is independently —H, or —C 1-4 alkyl; each R 7 is independently —H, —C 1-4 alkyl wherein —C 1-4 alkyl is optionally substituted with OR 6 , SR 6 3 , CO 2 R 6 , CONH 2 , NH 2 , NHC(═NH)NH 2 , phenyl, het, or R 6 and R 7 taken together form het; aryl is phenyl, biphenyl, or naphthyl; het is an aromatic ring, or a saturated or unsaturated ring that is not aromatic, of 3 to 10 carbon atoms and 1 to 4 heteroatoms selected from the group consisting of O, NQ, and S within the ring, wherein Q is absent, H, C 1-4 alkyl or —CO 2 C 1-4 alkyl; at each occurrence, C 1-10 alkyl is optionally substituted with 1-3 halo, OH, CN, NO 2 , OC 1-4 alkyl, NR 6 R 6 , C(═O)C 1-4 alkyl, OC(═O)C 1-4 alkyl, C(═O)OC 1-4 alkyl, phenyl or S(O) n C 1-4 alkyl; at each occurrence, C 3-7 cycloalkyl is optionally substituted with 1-3 halo, OH, CN, NO 2 , C 1-4 alkyl, OC 1-4 alkyl, NR 6 R 6 , C(═O)C 1-4 alkyl, OC(═O)C 1-4 alkyl, C(═O)OC 1-4 alkyl, or S(O) n C 1-4 alkyl; at each occurrence, aryl is optionally substituted with 1-3 halo, OH, CN, NO 2 , C 1-4 alkyl, OC 1-4 alkyl, NR 6 R 6 , C(═O)C 1-4 alkyl, OC(═O)C 1-4 alkyl, C(═O)OC 1-4 alkyl, or S(O) n C 1-4 alkyl; at each occurrence het is optionally substituted with 1-3 halo, OH, CN, NO 2 , C 1-4 alkyl, OC 1-4 alkyl, NR 6 R 6 , C(═O)C 1-4 alkyl, OC(═O)C 1-4 alkyl, C(═O)OC 1-4 alkyl, S(O) n C 1-4 alkyl, or oxo; and each n is independently 0-4.