Patent ID: 7820819

Claim:
A 2,4-pyrimidinediamine compound according to structural formula (II): wherein: R 5 is selected from the group consisting of fluoro, (C1-C3) haloalkyl, (C1-C3) perhaloalkyl, (C1-C3) haloalkoxy, (C1-C3) perhaloalkoxy, —C(O)R a , —C(O)OR a , C(O)CF 3 and —C(O)OCF 3 ; each R 11 R 12 , R 13 and R 14 , independently of the others, is selected from the group consisting of hydrogen, hydroxy, (C1-C6) perhaloalkyl, (C1-C6) perhaloalkoxy, —NR c R c , (C1-C10) alkyl optionally substituted with one or more of the same or different R a , (C1-C6) alkoxy optionally substituted with one or more of the same or different R a or R b ; —OR a optionally substituted with one or more of the same or different R a or R b groups, —O—(CH 2 ) m —NR c R c , —O—C(O)NR c R c , —O—(CH 2 ) m —C(O)NR c R c , —O—C(O)OR a , —O—(CH 2 ) m —C(O)OR a , —O—C(NH)NR c R c , —O—(CH 2 ) m —C(NH)NR c R c , —NH—(CH 2 ) m —NR c R c , —NH—C(O)NR c R c and —NH—(CH 2 ) m —C(O)NR c R c , where m is independently an integer from 1 to 3; each R a is independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C3-C8) cycloalkyl, (C4-C11) cycloalkylalkyl, (C5-C10) aryl, (C6-C16) arylalkyl, 2-6 membered heteroalkyl, 3-8 membered cycloheteroalkyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl and 6-16 membered heteroarylalkyl; each R b is a suitable group independently selected from the group consisting of ═O, (C1-C3) haloalkyloxy, ═S, —SR d , ═NR d , ═NOR d , halogen, —CF 3 , —CN, —NC, —OCN, —SCN, —NO, —NO 2 , ═N 2 , —N 3 , —S(O)R d , —S(O) 2 R d , —S(O) 2 OR d , —S(O)NR c R c , —S(O) 2 NR c R c , —OS(O)R d , —OS(O) 2 R d , —OS(O) 2 OR d , —OS(O) 2 NR c R c , —C(O)R d , —C(O)OR d , —C(O)NR c R c , —C(NH)NR c R c , —C(NR a )NR c R c , —C(NOH)R a , —C(NOH)NR c R c , —OC(O)R d , —OC(O)OR d , —OC(O)NR c R c , —OC(NH)NR c R c , —OC(NR a )NR c R c , —[NHC(O)] n R d , —[NR a C(O)] n R d , —[NHC(O)] n OR d , —[NR a C(O)] n ,OR d , —[NHC(O)] n NR c R c , —[NR a C(O)] n NR c R c , —[NHC(NH)] n NR c R c and —[NR a C(NR a )] n NR c R c , where n is independently an integer from 0 to 3; each R c is independently R a , or, alternatively, two R c are taken together with the nitrogen atom to which they are bonded to form a 5 to 8-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the same or different additional heteroatoms and which may optionally be substituted with one or more of the same or different R a or suitable R b groups; each R d is independently R a ; wherein at least one of R 11 and R 12 and one of R 13 and R 14 is non-hydrogen; with the proviso that: (1) R 11 and R 12 are not both methoxy; and (2) the 2,4-pyrimidinediamine compound is not: N2,N4-bis(4-ethoxyphenyl)-5-fluoro-2,4-pyrimidinediamine (R070790); N2,N4-bis(4-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine (R088814); N2,N4-bis(3-methylphenyl)-5-fluoro-2,4-pyrimidinediamine (R092788); or N2,N4-bis(3,4-dimethylphenyl)-5-fluoro-2,4-pyrimidinediamine (R067964).