Patent ID: 8383827

Claim:
A compound of Formula (II): or a pharmaceutically acceptable salt thereof, wherein A is a bond, —CH 2 —, —CHR 5 — or —CR 5 R 6 —; R 1 is C 1-7 alkyl, halo-C 1-7 alkyl, C 3-7 cycloalkyl, C 6-10 aryl, C 6-10 aryl-C 1-7 alkyl, C 6-10 aryloxy-C 1-7 alkyl, heteroaryl or heterocyclyl in which alkyl, aryl, heteroaryl, heterocyclyl are optionally substituted with 1 to 5 R 7 ; R 2 is H, C 1-7 alkyl, halo-C 1-7 alkyl or C 3-7 cycloalkyl; R 3 is H, halo, C 1-7 alkyl, halo-C 1-7 alkyl, C 3-7 cycloalkyl, cyano, C 1-7 alkoxy, hydroxy, nitro, —NH 2 , —NH(C 1-7 alkyl) or —N(C 1-7 alkyl) 2 ; each R 4 is independently selected from the group consisting of halo, C 1-7 alkyl, halo-C 1-7 alkyl, C 3-7 cycloalkyl, cyano, —NH 2 , —NH(C 1-7 alkyl), —N(C 7-7 alkyl) 2 , C 1-7 alkoxy, halo-C 1-7 alkoxy, hydroxy, carboxy, nitro, sulfonyl, sulfamoyl, sulfonamido, C 6-10 aryl, heterocyclyl, C 6-70 aryloxy, heterocyclyloxy, —SH, —S—C 1-7 alkyl, —C(O)O-aryl, —C(O)O-heterocyclyl, —C(O)O-heteroaryl, —C(O)NR 2 — C 1-7 alkyl, —C(O)NR 2 —C 6-10 aryl, —C(O)NR 2 -heteroaryl, —C(O)NR 2 -heterocyclyl, —NR 2 C(O)—C 1-7 alkyl, —NR 2 C(O)—C 6-10 aryl, —NR 2 C(O)-heteroaryl, —NR 2 C(O)-heterocyclyl, —OC(O)—C 1-7 alkyl, —OC(O)—C 6-10 aryl, —OC(O)-heteroaryl and —OC(O)-heterocyclyl; wherein R 4 is optionally substituted with 1 to 5 R 7 ; R 5 and R 6 are independently C 1-7 alkyl, C 3-7 cycloalkyl, halo-C 1-7 alkyl, heterocyclyl; each R 7 is independently selected from the group consisting of halo, C 1-7 alkyl, C 3-7 cycloalkyl, C 1-7 alkoxy, C 6-10 aryloxy, heterocyclyl, C 6-10 aryl, heteroaryl, CN and halo-C 1-7 alkyl; p is 0, 1, 2, 3, 4 or 5; and the compound of Formula I is not 2-methyl-N-(6-(5-(phenylsulfonamido)pyridin-3-yl)-1H-indazol-4-yl)thiazole-4-carboxamide, 2-chloro-N-isobutyl-N-((5-(3-(methylsulfonyl)phenyl)pyridin-3-yl)methyl)benzenesulfonamide or 4-(5-(4-chloro-2,5-dimethylphenylsulfonamido)pyridin-3-yl)benzoic acid.