Patent ID: 7217732

Claim:
A compound represented by the structural formula: or a pharmaceutically acceptable salt or solvate thereof; wherein: R 1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, haloalkyl, —N(R 7 ) 2 , substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein the term “substituted” means being substituted with (X) p ; R 2 is selected from the group consisting of hydogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, haloalkyl, —N(R 7 ) 2 , substituted or unsubstituted cyoloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein the term “substituted” means being substituted with (X) p ; R 3 is selected from the group consisting of alkyl, heteroalkyl, aryl, hetroaryl, Br, Cl, F, CF 3 , OCF 2 H, OCF 3 , and alkoxy, wherein R 3 can be the same or different and is independently selected when n>1; R 4 is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein the term “substituted” means being substituted with (X) p ; R 5 and R 6 , which can be the same or different, are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein the term “substituted” means being substituted with (X) p ; R 7 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, haloalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or two R 7 groups can form a ring of 4–7 carbon atoms, wherein the term “substituted” means being substituted with (X) p ; L 1 is selected from the group consisting of —S(O 2 )—, —S(O)—, and —S—; L 2 is selected from the group consisting of —S(O 2 )—, —S(O)—, —S—, and —C(O)—; M is n is 0–4; p is 0–5; X can be the same or different and is selected from the group consisting of Br, Cl, F, CF 3 , OH, OCF 2 H, OCF 3 , alkoxy, alkyl, cycloalkyl, —O-cycloalkyl, heteroalkyl, —C(O)N(R 7 ) 2 , —S(O 2 )R 2 , and —OS(O 2 )R 2 , wherein X is independently selected when p>1; Y is —S(O 2 )— and Z is selected from the group consisting of a covalent bond, —CH 2 —, —S(O 2 )—, and —C(O)—, with the following proviso: when Z is a covalent bond, R 2 is directly linked to the nitrogen atom shown in formula I.