Patent ID: 8349827

Claim:
A compound having formula I: or a pharmaceutically acceptable salt or ester thereof, wherein: X is R or NR 2 R 3 ; X 1 is N or CR X1 ; X 2 is N or CR X2 ; X 3 is N or CR X3 , provided that at least one of X 1 , X 2 and X 3 is N; R is H, hydroxyl, or -Q R -T R ; R X1 , R X2 and R X3 are each independently H or unsubstituted or substituted C 1 -C 6 alkyl; R 1 is H or -Q-T; R 2 and R 3 are each independently H or -Q-T, or R 2 and R 3 , together with the atom to which they attach, form a 5-, 6- or 7-membered ring which optionally comprises 1-4 heteroatoms selected from N, O and S and is optionally substituted; Q and Q R are each independently a bond or unsubstituted or substituted C 1 -C 6 alkyl linker; T is H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 1 -C 6 alkoxy, unsubstituted or substituted amino, unsubstituted or substituted C 1 -C 6 alkylamino, unsubstituted or substituted di-C 1 -C 6 alkylamino, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted C 6 -C 10 aryloxy, unsubstituted or substituted C 6 -C 10 aryl-C 1 -C 6 alkyl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S; T R is H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 1 -C 6 alkoxy, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted C 6 -C 10 aryloxy, unsubstituted or substituted C 6 -C 10 aryl-C 1 -C 6 alkyl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S; p and q are each independently 0, 1, 2 or 3; each R 4 is independently unsubstituted or substituted C 1 -C 6 alkyl; each R 5 is independently unsubstituted or substituted C 1 -C 6 alkyl; and R 6 is H or unsubstituted or substituted C 1 -C 6 alkyl.