Patent ID: 7816346

Claim:
A compound or pharmaceutically acceptable salt thereof having the formula (I) wherein X is selected from the group consisting of —N(R 8 )(R 9 ), —N(R 8 )—C(O)R 10 , —N(R 8 )—C(O)—OR 10 , —N(R 8 )—SO 2 R 10 , —N(R 8 )—C(O)—NR 8 R 10 , —N(R 8 )—C(S)OR 10 , —N(R 8 )—C(S)—OR 10 , and —N(R 8 )—C(S)—NR 8 R 10 ; wherein R 8 and R 9 are independently selected from the group consisting of H, (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, cycloalkyl, and heterocyclic alkyl; R 8 is selected from the group consisting of H, (C 1 -C 6 ) alkyl, optionally substituted (C 5 -C 8 ) aryl, and an optionally substituted (C 5 -C 8 ) heteroaryl, or together with R 9 forms a 4-7 membered heterocyclic ring; R 10 is selected from the group consisting of hydrogen, (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl, optionally substituted (C 6 -C 20 ) aryl, optionally substituted (C 3 -C 20 ) heteroaryl, optionally substituted (C 7 -C 20 ) arylalkyl, optionally substituted (C 4 -C 20 ) heteroarylalkyl, (C 3 -C 20 ) cycloalkyl, and a (C 2 -C 20 ) alicyclic heterocyclyl; R represents, hydrogen, (C 1 -C 6 ) alkyl or (C 1 -C 6 ) alkenyl or (C 6 -C 10 ) aryl or OCOR 10 ; R 1 and R 2 are each a hydrogen or R 1 and R 2 together form a single bond; R 3 , R 4 , Y 1 , Y 2 , Y 3 are independently selected from the group consisting H, halo, —OH, O-alkyl, O-acetyl, —O-aryl, OC(O)R 10 , —SO 2 —R 10 , and —NHR 10 , or together form oxo (═O), or hydroxylamino alkoxyimine or aryloxyimine, thioketo; or R 3 and R 4 or Y 1 and Y 2 form a heterocyclic group selected from the group consisting of aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, thiazolidinyl, oxazolidinyl, morpholino, piperazinyl, 4-(C 1 -C 4 ) alkylpiperidinyl and N—(C 1 -C 4 ) piperazinyl; and said groups may be substituted with one or more groups selected from the group consisting of (C 1 -C 8 ) alkyl, halo, nitro, amino, azido and (C 1 -C 8 ) alkoxyl; R 5 is selected from the group consisting of a (C 1 -C 20 ) alkyl, (C 2 -C 20 ) alkenyl, (C 2 -C 20 ) alkynyl, optionally substituted (C 6 -C 20 ) aryl, optionally substituted (C 3 -C 20 ) heteroaryl, optionally substituted (C 7 -C 20 ) arylalkyl, optionally substituted (C 4 -C 20 ) heteroarylalkyl, (C 3 -C 20 ) cycloalkyl, (C 2 -C 20 ) alicyclic heterocyclyl, N(R 8 )(R 9 ); —OR 10 , —SR 10 , —N(R 8 )—C(O)R 10 , —N(R 8 )—C(O)—OR 10 , —N(R 8 )—C(O)—NR 8 R 10 , —N(R 8 )—C(S)OR 10 , —N(R 8 )—C(S)—OR 10 , and —N(R 8 )—C(S)—NR 8 R 10 , R 6 is selected from the group consisting of, hydrogen, hallo, a (C 1 -C 10 ) alkyl, (C 1 -C 10 ) alkenyl, or an optionally substituted or unsubstituted (C 6 -C 10 ) aryl; and R 7 is selected from the group consisted of hydrogen, a (C 1 -C 10 ) alkyl, optionally substituted (C 5 -C 10 ) aryl and (C 1 -C 10 ) acyl.