Patent ID: 8426416

Claim:
A compound of formula (I), or a pharmaceutically acceptable addition salt or a stereo-chemically isomeric form thereof, wherein each X is CH: R 1 is phenyl, naphtalenyl or heterocyclyl; wherein each of said phenyl or naphtalenyl is optionally substituted with one or two substituents that are each independently halo, C 1-6 alkyl, C 1-6 alkyloxy, polyhalo C 1-6 alkyl, aryl, hydroxy, cyano, amino, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, hydroxyl C 1-6 alkyl, C 1-6 alkyloxymethyl, aminomethyl, C 1-6 alkylaminomethyl, C 1-6 alkylcarbonylaminomethyl, C 1-6 alkylsulfonylaminomethyl, aminosulfonyl, C 1-6 alkylaminosulfonyl or heterocyclyl; R 2 is hydrogen, —CH 2 —R 5 , trifluoromethyl, —C(═O)—R 6 , or —CH 2 —NR 7 R 8 ; wherein each R 5 is independently hydrogen, hydroxy, C 1-6 alkyloxy, C 1-6 alkyloxy C 1-6 alkyloxy, C 1-6 alkylcarbonyloxy, piperazinyl, N-methylpiperazinyl, morpholinyl, thiomorpholinyl, imidazolyl or triazolyl; each R 6 is independently hydroxy, C 1-6 alkyloxy, amino or mono- or di(C 1-6 alkyl)amino, C 1-6 cycloalkylamino, hydroxyC 1-6 alkylamino, piperazinyl, mono- or di(C 1-6 alkyl)amino C 1-6 alkylamino N-methylpiperazinyl, morpholinyl or thiomorpholinyl; each R 7 and R 8 are independently hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl, or mono-or di(C 1-4 alkyl)aminosulfonyl; R 3 is hydrogen, hydroxymethyl, aminomethyl or mono- or di(C 1-6 alkyl)aminomethyl; R 4 is hydrogen or C 1-6 alkyl; aryl is phenyl or naphtalenyl; wherein each of said phenyl or naphtalenyl is optionally substituted with one or two substituents that are each independently halo, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, cyano or hydroxycarbonyl; and heterocyclyl is furanyl, thienyl, pyrrolyl, pyrrolinyl, pyrolidinyl, dioxolyl, oxazolyl, thiazolyl, imidazolyl, imidazolinyl, imidazolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyranyl, pyridinyl, piperidinyl, dioxanyl, morpholinyl, dithianyl, thiomorpholinyl, pyridazinyl, pyrimidinyl, pyrazinyl, piperazinyl, triazinyl, trithianyl, indolizinyl, indolyl, indolinyl, benzofuranyl, benzothiophenyl, indazolyl, benzimidazolyl, benzthiazolyl, purinyl, quinolizinyl, quinolinyl, cinnolinyl, phthlazinyl, quinazolinyl, quinoxalinyl or naphthyridinyl; wherein each of said heterocycles is optionally substituted with one or two substituents that are each independently halo, C 1-6 alkyl, C 1-6 alkyloxy, cyano, amino, mono-or di(C 1-4 alkyl)amino.