Patent ID: 6916794

Claim:
A method of enhancing drainage of the lacrimal system comprising the step of administering to the eyes of a subject an effective amount of a preparation comprising a dinucleoside polyphosphate as depicted in Formulae II, or a pharmaceutically acceptable salt therof; whereby said preparation is effective in enhancing drainage of the lacrimal system in the eyes in the subject: wherein: X is oxygen, imido, methylene or difluoromethylene; n=0 or 1; m=0 or 1; n+m=0, 1 or 2; and B and B′ are each independently a purine residue, as in Formula IIa, or a pyrimidine residue, as in Formula IIb, linked through the 9- or 1-position, respectively: wherein: R 3 is H or NHR 1 ; R 1 of the 6- or 8-HNR 1 groups is selected from the group consisting of hydrogen, arylalkyl (C 1-6 ) groups, and alkyl groups with functional groups selected from the group consisting of carbamoylmethyl, and ω-acylated-amino, hydroxy, thiol or carboxy derivatives, where the acyl group is selected from the group consisting of acetyl, trifluoroacetyl, benzoyl, and substituted-benzoyl; R 2 is O or absent; or R 1 and R 2 taken together form a substituted 5-membered fused imidazole ring: whernein: R 4 is hydroxy, mercapto, amino, cyano, aralkoxy, C 1-6 alkoxy, C 1-6 alkylamino or dialkylamino, with the alkyl groups optionally linked to form a heterocycle; R 5 is hydrogen, acyl, C 1-6 alkyl, aroyl, C 1-5 alkanoyl, beuzoyl, or suiphonate; R 6 is hydroxy, mercapto, alkoxy, aralkoxy, C 1-6 -alkylthio, C 1-5 disubstituted amino, triazolyl, alkylamino or dialkylamino, where the alkyl groups are optionally linked to form a heterocycle or linked to N 3 to form an optionally substituted ring; R 7 is hydrogen, hydroxy, cyano, nitro, alkenyl with the alkenyl moiety optionally linked through oxygen to form a ring optionally substituted on the carbon adjacent to the oxygen with alkyl or aryl groups, substituted alkynyl, halogen, alkyl, substituted alkyl, perhalomethyl, C 2-6 alkyl, C 2-3 alkenyl, or substituted ethenyl, C 2-3 alkynyl or substituted alkynyl; or together R 6 -R 7 form a 5 or 6-membered saturated or unsaturated ring bonded through N or O at R 6 , such a ring optionally contains substituents that themselves contain functionalities; provided that when R 8 is amino or substituted amino, R 7 is hydrogen; and R 8 is hydrogen, alkoxy, arylalkoxy, alkylthio, arylalkylthio, carboxamidomethyl, carboxymethyl, methoxy, methylthio, phenoxy or phenylthio.