Patent ID: 7705188

Claim:
A method for synthesizing the compound 14g having the following structure and wherein R 1 ═—OH and R 2 ═R 3 ═—OCH 3 : comprising the following steps: (a) protecting 3,5-dihydroxybenzaldehyde by reacting it in dimethylformamide with DIEA and silyl chloride; (b) separating the products of step (a) to obtain 3-(tert-butyldimethylsilyloxy)-5-hydroxybenzaldehyde; (c) adding to the 3-(tert-butyldimethylsilyloxy)-5-hydroxybenzaldehyde obtained in step (b) molecular sieves, proton sponge and trimethyloxonium tetrafluoroborate, then stirring, then filtering, then rinsing sieves with ethyl acetate, then removing the ethyl acetate containing solvent from the filtrate to yield an oil; (d) purifying the oil produced in step (c), to yield 3-(tert-butyldimethylsilyloxy)-5-methoxybenzaldehyde; (e) reacting the 3-(tert-butyldimethylsilyloxy)-5-methoxybenzaldehyde produced in step (d) with 4-(tert-butyldiphenylsilyloxy)-benzyltriphenyl phosphonium bromide to produce (Z)- and (E)-3-(tert-butyldimethylsilyloxy)-5,4′-dimethoxy-stilbene; and (f) deprotecting, and then separating, the product of step (e), to obtain compound 14g.