Patent ID: 7560473

Claim:
An amine derivative represented by formula I a , its racemes or optical isomers, its pharmaceutical acid addition salts or its amides or esters, wherein, (1) when R′ 1 is isopropyl and each of R′ 2 and R′ 3 represents methyl, R′ 4 may be isopropyl, n-butyl, isobutyl, t-butyl, cyclopropylmethyl, allyl, dimethylaminoethyl, diisopropyl laminoethyl; or (2) when each of R′ 1 and R′ 2 represents methyl, R′ 3 —C—NH—R′ 4 may be an amine derivative represented by following formula I′ a , racemes or optical isomers thereof, wherein each of R and R′ represents C 1-5 hydrocarbyl, n represents an integer of one to eight; or when R′ 1 represents H 2 NC(CH 3 ) 2 —, and each of R′ 2 and R′ 3 represents methyl, R′ 4 represents isopropyl; or when R′ 1 represents HOC(CH 3 ) 2 —, and each of R′ 2 and R′ 3 represents methyl, R′ 4 represents (CH 3 ) 2 CH—or (CH 3 ) 2 CH(CH 3 )—; or when R′ 1 represents 1-hydroxylcyclohexyl, and each of R′ 2 and R′ 3 represents methyl, or R′ 2 and R′ 3 together represent —(CH 2 ) 4- or (CH 2 ) 5 —, R′ 4 represents (CH 3 ) 2 CH—; or when R′ 1 represents O 2 NOC(CH 3 ) 2 —, and each of R′ 2 and R′ 3 represents methyl, R′ 4 represents (CH 3 ) 2 CH—; or when R′ 1 represents and each of R′ 2 and R′ 3 represents methyl, or R′ 2 and R′ 3 together represent —(CH 2 ) 4 —or (CH 2 ) 5 —, R′ 4 represents (CH 3 ) 2 CH—; or when R′ 1 represents and each of R′ 2 and R′ 3 represents methyl, R′ 4 represents (CH 3 ) 2 CH—or (CH 3 ) 2 CH(CH 3 )—; or when R′ 1 represents and each of R′ 2 and R′ 3 represents (CH 2 ) 5 —, R′ 4 represents (CH 3 ) 2 CCH(CH 3 )—; or (4) when R′ 1 represents cyclohexyl, and each of R′ 2 and R′ 3 represents methyl, R′ 4 may represent or when R′ 1 represents cyclopentyl, and R′ 2 and R′ 3 both represent —(CH 2 ) 2 —, R′ 4 may represent or when R′ 1 represents isopropyl, and each of R′ 2 and R′ 3 represents methyl, R′ 4 may represent or (5) when R′ 1 represents isopropyl, and each of R′ 2 and R′ 3 represents methyl, R′ 4 may represent Val-, Trp-, lle-, Leu-, Phe-, O 2 N-Arg-, Pro-, Leu-Val-, Trp-Trp-Trp- or (CH 3 ) 2 CH—SO 2 —; or R 4 ′ may represent tosyl, nicotinyl, 4-chlorobenzoyl, morphorinoacetyl, 3-thienylacetyl, or 3-indotylacetyl; or when R′ 1 represents cyclopropyl, and each of R′ 2 and R′ 3 represents —(CH 2 ) 2 —, R′ 4 represents Val-; or when R′ 1 represents cyclohexyl, and each of R′ 2 and R′ 3 represents methyl, R′ 4 represents Pro-; or when R′ 1 represents cyclohexyl, and each of R′ 2 and R′ 3 represents —(CH 2 ) 2 —, R′ 4 represents Pro- or nicotinyl.