Patent ID: 7732464

Claim:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof, wherein —R 1 —R 2 — is a bivalent radical of formula —O—CH 2 —CH 2 —O— (a-3), or —O—CH 2 —CH 2 —CH 2 —O— (a-5), wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C 1-6 alkyl or hydroxy, R 3 is hydrogen, halo, C 1-6 alkyl or C 1-6 alkyloxy; R 4 is hydrogen, halo, C 1-6 alkyl; C 1-6 alkyl substituted with cyano, or C 1-6 alkyloxy; C 1-6 alkyloxy; cyano; amino or mono or di(C 1-6 alkyl)amino; R 5 is hydrogen or C 1-6 alkyl, and the —OR 5 radical is situated at the 3- or 4-position of the piperidine moiety; L is a radical of formula -Alk-R 6 (b-1), -Alk-X—R 7 (b-2), wherein each Alk is C 1-12 alkanediyl; and R 6 is Het; R 7 is Het; X is O, S, SO 2 or NR 8 ; said R 8 being hydrogen or C 1-6 alkyl; and Het is morpholinyl; morpholinyl substituted with C 1-6 alkyl; tetrazolyl; tetrazolyl substituted with halo, hydroxy, or C 1-6 alkyl; pyrazolyl; pyrazolyl substituted with halo, hydroxy, or C 1-6 alkyl; isoxazolyl; isoxazolyl substituted with halo, hydroxy, or C 1-16 alkyl; isothiazolyl; isothiazolyl substituted with halo, hydroxy, or C 1-6 alkyl; 2,4-dioxo-imidazolidinyl; 2,4-dioxo-imidazolidinyl substituted with one or two substitutents each independently selected from halo, or C 1-6 alkyl; oxazolyl; oxazolyl substituted with halo, hydroxy, or C 1-6 alkyl; thiazolyl; thiazolyl substituted with halo, hydroxy, or C 1-6 alkyl; or pyranyl; pyranyl substituted with halo, hydroxy, or C 1-6 alkyl.