Patent ID: 8524491

Claim:
An isolated nucleic acid molecule directing the expression of a polypeptide encoded by a DNA sequence selected from: (a) nucleotides 2026 through 3765 of SEQ ID NO: 1; and (b) DNA sequences that hybridize to a nucleotide sequence complementary to nucleotides 2026 through 3765 of SEQ ID NO: 1 under moderately stringent conditions, wherein the DNA sequence encodes a polypeptide that produces an immune response to HER-2/neu protein, and wherein the hybridization conditions comprise prewashing in a solution of 5×SSC, 0.5% SDS, 1.0 mM EDTA (pH8.0); hybridization at 50° to 65° C. in 5×SSC overnight; followed by washing twice at 65° for 20 minutes with each of 2×, 0.5× and 0.2×SSC containing 0.1% SDS; with the provisos that the polypeptide of (b) is not intact HER-2/neu protein and does not include the extracellular domain of HER-2/neu protein.