Patent ID: 8288386

Claim:
A compound of the following formula 1, wherein R 1 represents hydrogen, or represents C 1 -C 10 -alkyl, C 3 -C 7 -cycloalkyl, C 6 -C 10 -aryl, heterocycle or heteroaryl, each of which is unsubstituted or substituted with at least one substituent selected from the group consisting of halogen, amino, C 1 -C 4 -alkyl, trifluoromethyl, hydroxy, C 1 -C 4 -alkoxy, cyano and oxo; R 2 represents phenyl or six-membered heteroaryl, each of which is unsubstituted or mono- or di-substituted with substituent(s) selected from the group consisting of halogen, hydroxy, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, cyano and amino; R 3 represents hydrogen, or represents C 1 -C 6 -alkyl or C 3 -C 7 -cycloalkyl, each of which is unsubstituted or substituted with substituent(s) selected from the group consisting of halogen, methyl, trifluoromethyl, hydroxy and amino; R 4 represents C 4 -C 7 -cycloalkyl or monocyclic heterocycle, each of which is unsubstituted or mono- or poly-substituted with substituent(s) selected from the group consisting of halogen, hydroxy, C 1 -C 4 -alkyl, trifluoromethyl, C 1 -C 4 -alkoxy and oxo; or represents phenyl or six-membered heteroaryl, each of which is unsubstituted or mono- or di-substituted with substituent(s) selected from the group consisting of halogen, hydroxy, C 1 -C 4 -alkyl, trifluoromethyl, C 1 -C 4 -alkoxy and amino; and R 5 represents C 1 -C 6 -alkyl, difluoromethyl, trifluoromethyl, C 3 -C 8 -cycloalkyl, amino, C 1 -C 4 -alkylamino, di(C 1 -C 4 -alkyl)amino, phenyl, monocyclic heteroaryl or monocyclic heterocycle where alkyl is unsubstituted or substituted with at least one substituent selected from the group consisting of fluoro, hydroxy, mercapto, C 1 -C 4 alkoxy, acetoxy, amino, acetylamino, cyano, carbamoyl, dimethyl carbamoyl and oxo and phenyl or heteroaryl is unsubstituted or mono- or di-substituted with substituent(s) selected from the group consisting of halogen, hydroxy, methyl, trifluoromethyl, methoxy and amino, in which, heteroaryl represents imidazole, oxazole, thiazole, pyrazole, triazole, pyridine, pyrimidine, pyridazine or furan, and heterocycle represents oxazoline, imidazoline, thiazoline, tetrahydropyran, tetrahydrothiopyran, piperidine, tetrahydrofuran or dihydrofuran, or pharmaceutically acceptable salt or stereoisomer thereof.