Patent ID: 7973061

Claim:
A compound according to Formula I, or a pharmaceutically acceptable salt, or hydrate thereof, wherein, each of R 1 and R 2 is independently selected from —H, halogen, trihalomethyl, —CN, —NO 2 , —NH 2 , —NR 7 R 8 , —S(O) 0-2 R 7 , —SO 2 NR 7 R 7 , —CO 2 R 7 , —C(O)NR 7 R 7 , —N(R 7 )SO 2 R 7 , —N(R 7 )C(O)R 7 , —N(R 7 )CO 2 R 7 , —C(O)R 7 , optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl; or combined, R 1 and R 2 are oxo; R 3 is selected from —H, optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl; R 4 is —CH 2 —O-Ph, where Ph is an optionally substituted phenyl; X is selected from —O—, —N(R a )—, and —S(O) 0-2 —; Y is ═C(R b )— or ═N—; one of Z is ═C(C(═O)W)—, while the other Z is ═C(R c )— or ═N—; W is —N(R 5 )R 6 ; L is selected from —C(═O)—; R 5 is —H or R 6 ; R 6 is optionally substituted aryl C 1-6 alkyl or optionally substituted heterocyclyl C 1-6 alkyl; R 7 is —H or R 8 ; R 8 is selected from optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl; R 7 and R 8 , when taken together with a common nitrogen to which they are attached, form an optionally substituted five- to seven-membered heterocyclyl, said optionally substituted five- to seven-membered heterocyclyl optionally containing at least one additional annular heteroatom selected from N, O, S, and P; and each of R a , R b , and R c is independently selected from —H, optionally substituted C 1-6 alkyl, optionally substituted aryl, optionally substituted aryl C 1-6 alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C 1-6 alkyl.