Patent ID: 7115617

Claim:
A compound of Formula I wherein R 1 is isoxazolyl, wherein R 1 is optionally substituted with 1–2 substituents independently selected from R 3 ; wherein R 2 is selected from R 4 and phenyl optionally substituted with 1–4 substituents independently selected from R 3 ; wherein R 3 is independently selected from C 1-4 -alkyl, C 2-4 -alkenyl, C 2-4 -alkynyl, phenyl, R 4 , chloro, fluoro, bromo, trifluoromethyl, C 1-4 -alkoxy, phenoxy, heterocyclyloxy, benzyloxy, C 1-4 -alkylcarbonyloxy, amino, alkylamino, phenylamino, carboxy, C 1-4 -alkoxycarbonyl, nitro, cyano, C 1-4 -alkylcarbonyl, aminocarbonyl, C 1-4 -alkylaminocarbonyl, C 1-4 -alkylsulfonyl, C 1-4 -alkylaminosulfonyl, benzyl, C 1-4 -alkoxyalkyl, C 1-4 -aminoalkyl, C 1-4 -alkylaminoalkyl, and 5–6-membered heterocyclyl-C 1-4 -alkyl; wherein R 4 is independently a 6 membered monocyclic, or 8–10 membered bicyclic saturated, partially saturated or unsaturated ring system comprising 1–3 heteroatoms if monocyclic, 1–6 heteroatoms if bicyclic, said heteroatoms independently selected from O, N, or S, which may be saturated or unsaturated, and wherein 0, 1, 2 or 3 atoms of each ring may be substituted by a substituent independently selected from C 1-4 -alkyl, halo, C 1-6 -haloalkyl, oxo, OR 5 , NR 5 R 5 , COOR 5 , nitro, cyano, S(O) n R 5 , S(O) n NR 5 R 5 , C(O)R 5 and C(O)NR 5 R 5 ; and wherein R 5 is selected from H, C 1-6 -alkyl, and phenyl optionally substituted with 1–3 substituents independently selected from C 1-4 -alkyl, chloro, fluoro, —CF 3 , hydroxy, C 1-4 -alkoxy, amino, C 1-4 -alkylamino, carboxy, C 1-4 -alkoxycarbonyl, nitro, cyano, C 1-4 -alkylcarbonyl, C 1-4 -alkylamnocarbonyl, aminocarbonyl, aminosulfonyl and acetyl; or a pharmaceutically acceptable salt thereof.