Patent ID: 8329712

Claim:
A compound according to formula (I) wherein: X is CH or N: R 1 is selected from the group consisting of R 1a , R 1b , R 1c , R 1d and R 1e : wherein R 5 is hydrogen or C 1-3 alkyl and R 1a is optionally substituted by halogen, C 1-6 alkyl, C 1-3 haloalkyl, C 1-6 alkoxy, or hydroxy; R 2 is (a) aryl, (b) heteroaryl wherein said heteroaryl is a pyridine, pyrazine or pyridazine ring or (c) NR a R b , wherein said aryl or said heteroaryl are optionally independently substituted with one to three substitutents selected from the group consisting of hydroxy, C 1-6 alkoxy, C 1-6 alkyl, C 1-6 hydroxyalkyl, halogen, (CH 2 ) n NR c R d , cyano, C 1-6 alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, (CH 2 ) 0-2 CO 2 H, SO 2 NH 2 , C 1-6 alkylsulfinyl and C 1-6 alkylsulfonyl; R a and R b along with the nitrogen to which they are attached are a pyrrolidine ring substituted by (CH 2 ) n NR c R d wherein n is zero to two and additionally optionally substituted by one or two groups independently selected from C 1-6 alkyl or halogen; R c and R d are independently hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 acyl, O 2 SR 4 wherein R 4 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-3 alkyl, C 1-6 alkoxy-C 1-6 alkyl, —SO 2 —NR e R f ; R e and R f are (i) independently hydrogen, C 1-3 alkyl or (CH 2 ) 2-6 NR g R h or (ii) together with the nitrogen to which they are attached are (CH 2 ) 2 X 5 (CH 2 ) 2 wherein X 5 is O or NR g and R g is hydrogen, C 1-3 alkyl, C 1-3 acyl or C 1-3 alkylsulfonyl; R 3 is CF 3 , CH 2 CF 3 , C 3-5 cycloalkyl, halogen, C 1-6 alkoxy, C 1-3 haloalkoxy, CHR 4a R 4b or CR 4a R 4b R 4c wherein: (i) R 4a , R 4b and R 4c are independently selected from C 1-3 alkyl, CD 3 , C 1-2 alkoxy, C 1-2 fluoroalkyl, C 1-3 hydroxyalkyl, cyano or hydroxy; or (ii) when taken together, R 4a and R 4b together are C 2-4 alkylene and R 4c is hydrogen, C 1-3 alkyl, CD 3 , C 1-2 alkoxy, halogen, C 1-3 hydroxyalkyl, cyano or C 1-2 fluoroallyl or R 4a and R 4b together with the carbon to which they are attached are 3-oxetanyl, or tetrahydrofuran-2-yl; or, a pharmaceutically acceptable salt thereof.