Patent ID: 7893051

Claim:
A compound of the formula where X is S; R 1 and R 2 taken together with the atoms to which they are attached form a 5-7-member carbocycle or heterocycle substituted with up to two substituents selected from alkyl, CF 3 , and —OR 8 ; R 3 is selected from the group consisting of H, C 1-8 alkyl, OR 8 , aryl and heteroaryl; R 3a is H or C 1-8 alkyl; or R 3 and R 3a taken together are —CH 2 CH 2 —; R 4 is selected from the group consisting of H, C 1-8 alkyl and OR 8 ; R 4a is H, C 1-8 alkyl; or R 4 and R 4a taken together are —CH 2 CH 2 —; R 5 is selected from the group consisting of H, —C 1-8 alkyl, —C 1-8 alkyl-O—C 1-8 alkyl, C 1-8 alkylaryl, —C 1-8 alkylheteroaryl, —C 1-8 alkyl-O-aryl and C 1-8 alkyl-O-heteroaryl; R 5a is H or —C 1-8 alkyl; R 6 is selected from the group consisting of H, —C 1-8 alkyl, C 1-8 alkyl-O—C 1-8 alkyl, C 1-9 alkylaryl, C 1-9 alkylheteroaryl, —C 1-8 alkyl-O-aryl and —C 1-8 alkyl-O-heteroaryl; R 6a is H or —C 1-8 alkyl; R 7 is selected from the group consisting of H, —C 1-8 alkyl, —C 1-8 alkylary and —C 1-8 alkylheteroaryl; R 8 is selected from the group consisting of H, —C 1-8 alkyl, —C 2-8 alkenyl, —C 2-8 alkynyl, aryl, heteroaryl, —C 1-8 alkylaryl, —C 1-8 alkyl heteroaryl, —C 1-8 alkyl-O—C 1-8 alkyl, —C 1-8 alkyl —O-aryl and —C 1-8 alkyl —O-heteroaryl; or wherein aryl and heteroaryl in R 3 , R 5 , R 6 , R 7 and R 8 substituents may be optionally substituted with up to two substituents selected from —C 1-8 alkyl, halogen, CN, and alkoxy, or a pharmaceutically acceptable salt thereof.