Patent ID: 7049285

Claim:
A biologically active conjugate of the following formula: {[P—OCH 2 CO—(Y)] n -(L) s -(Q) t -(Y′) k -A 1 } z -biologically active molecule, wherein: P and Q may be the same or different and independently represent a biocompatible polymer; t is an integer of 0 or 1; Y and Y′ may be the same or different and independently represent a peptide consisting of from 2 to 18 amino acid residues; k is an integer of 0 or 1; L represents aliphatic linking moiety or diaminocarboxylic acid; s is an integer of 0 or 1; n is an integer of 1 or 2; A 1 is a linker between a biocompatible polymer and a biologically active molecule which comprises a functional group selected from the group consisting of —NHS, —NHNH2, carbonyl imidazole, nitrophenyl, isocyanate, sulfonyl chloride, aldehyde, glyoxal, epoxide, carbonate, cyanuric halide, dithiocarbonate, tosylate and maleimide; and z is an integer of 1 or more as the number of polymers attached to the biologically active molecule, and wherein the conjugate is stable whereby the half-life of the biologically active molecule in the conjugate extends in vivo.