Patent ID: 8425904

Claim:
A method of treating cancer in a subject comprising administering to the subject a human monoclonal antibody, or an antigen-binding portion thereof, such that the cancer is treated in the subject, wherein the antibody binds human mesothelin and exhibits at least one of the following properties: (a) binds to human mesothelin with a K D of 1×10 −8 M or less; (b) is internalized by mesothelin-expressing cells; (c) inhibits binding of mesothelin to ovarian cancer antigen CA125; (d) exhibits antibody dependent cellular cytotoxicity (ADCC) against mesothelin-expressing cells; or (e) inhibits growth of mesothelin-expressing cells in vivo when conjugated to a cytotoxin; and wherein, the antibody comprises: (a) a heavy chain variable region CDR1 comprising SEQ ID NO: 1; (b) a heavy chain variable region CDR2 comprising SEQ ID NO: 4; (c) a heavy chain variable region CDR3 comprising SEQ ID NO: 7; (d) a light chain variable region CDR1 comprising SEQ ID NO: 10; (e) a light chain variable region CDR2 comprising SEQ ID NO: 13; and (f) a light chain variable region CDR3 comprising SEQ ID NO: 16; or (a) a heavy chain variable region CDR1 comprising SEQ ID NO: 2; (b) a heavy chain variable region CDR2 comprising SEQ ID NO: 5; (c) a heavy chain variable region CDR3 comprising SEQ ID NO: 8; (d) a light chain variable region CDR1 comprising SEQ ID NO: 11; (e) a light chain variable region CDR2 comprising SEQ ID NO: 14; and (f) a light chain variable region CDR3 comprising SEQ ID NO: 17; or (a) a heavy chain variable region CDR1 comprising SEQ ID NO: 3; (b) a heavy chain variable region CDR2 comprising SEQ ID NO: 6; (c) a heavy chain variable region CDR3 comprising SEQ ID NO: 9; (d) a light chain variable region CDR1 comprising SEQ ID NO: 12; (e) a light chain variable region CDR2 comprising SEQ ID NO: 15; and (f) a light chain variable region CDR3 comprising SEQ ID NO: 18.