Patent ID: 7319104

Claim:
A compound of formula (1) or a pharmaceutically acceptable salt, acid isostere, or hydrolyzable ester thereof; wherein R 1 and R 2 are independently hydrogen, F, CF 3 , C 1-3 alkyl, or R 1 and R 2 may together with the carbon atom to which they are attached form a 3 to 6-membered cycloalkyl ring; R 4 and R 5 are independently hydrogen, C 1-6 alkyl, perfluoroC 1-6 alkyl, —OC 1-3 alkyl, perfluoroOC 1-6 alkyl, halogen, or cyano; R 7 and R 8 are independently H, F, CF 3 , or C 1-3 alkyl, and the carbon to which R 7 and R 8 are bonded is attached to the benzene ring either meta or para to the depicted oxygen; n is 1 or 2; y is 1 or 2; R 6 is phenyl or a 5- or 6-membered heteroaryl group, where the phenyl or heteroaryl group is optionally substituted with 1, 2, or 3 moieties selected from the group consisting of C 1-6 alkyl, halogen, perfluoroC 1-3 alkyl, OC 1-3 alkyl, perfluoroOC 1-3 alkyl, SC 1-3 alkyl, SO 2 C 1-3 alkyl, SO 2 C 1-3 perfluoroalkyl, SOC 1-3 perfluoroalkyl, SOC 1-3 alkyl, perfluoroSC 1-3 alkyl, CN, and phenyl optionally substituted with one or two groups selected from halogen, C 1-3 alkyl, OC 1-3 alkyl, acetyl, CN, and perfluoroC 1-3 alkyl, or R 6 is phenyl or a 5- or 6-membered heteroaryl group, where the phenyl or heteroaryl group is optionally substituted with 1, 2, or 3, 5—or 6—membered heteroaryl moieties optionally substituted with one group selected from C 1-3 alkyl, C 3-6 cycloalkyl, perfluoroC 1-3 alkyl, NHC 1-3 alkyl, and N(C 1-3 alkyl) 2 ; R 3 is a 5- or 6-membered heteroaryl group optionally substituted by 1 or 2 moieties selected from the group consisting of halogen, C 1-6 alkyl, perfluoroC 1-6 alkyl, OC 1-3 alkyl, and phenyl optionally substituted with one or two moieties selected from C 1-3 alkyl, halogen, OC 1-3 alkyl, acetyl, CN, OperfluoroC 1-3 alkyl, and perfluoroC 1-3 alkyl, or R 3 is a 5— or 6—membered heteroaryl group optionally substituted by 1 or 2 moieties selected from the group consisting of 5- or 6-membered heteroaryl optionally substituted with one or two moieties selected from C 1-3 alkyl, halogen, OC 1-3 alkyl, acetyl, CN, and perfluoroC 1-3 alkyl, hydroxyC 1-3 alkyl, C 3-7 cycloalkyl, cyanoC 1-3 alkyl, acetyl, nitro, N(CH 3 ) 2 , NHR 21 , piperidin-4-yl substituted at nitrogen with a moiety selected from C 1-5 alkyl, benzyl, acetyl, C(O)OC 1-5 alkyl, C(O)Obenzyl, C(O)NH 2 , C(O)NHC 1-3 alkyl, and SO 2 CH 3 , 4-(4-fluorophenyl)piperazin-1-ylmethyl, morpholin-4-ylmethyl, tetrahydrofuran-3-yl, or two adjacent carbon atoms in the heteroaryl could be substituted to form a benzene ring thus forming a fused bicycle and wherein the resulting benzene ring is optionally substituted with one or two moieties selected from C 1-3 alkyl, halogen, and perfluoroC 1-3 alkyl; and R 21 is C 1—3 alkyl, —C(O)C 1—3 alkyl, —C(O)OC 1—3 alkyl, or SO 2 CH 3 .