Patent ID: 7455963

Claim:
A method of identifying an inhibitor of cyclin E2 polypeptide/cdk2 complex formation, comprising: (a) providing a sample comprising a purified cyclin E2 polypeptide and a purified cdk2 under conditions wherein said cyclin E2 polypeptide and said cdk2 spontaneously associate to form said cyclin E2 polypeptide/cdk2 complex, wherein said cyclin E2 polypeptide has the amino acid sequence selected from the group consisting of SEQ ID NOS: 3, 4, or 6; (b) adding at least one test molecule to said sample of (a); (c) assaying for a decrease in the amount of said complexed cyclin E2 polypeptide/cdk2 relative to that in said sample of (a) to identify said at least one test molecule as an inhibitor of cyclin E2 polypeptide/cdk2 complex formation.