Patent ID: 7253160

Claim:
A compound having the structure shown in Formula 1: or a pharmaceutically acceptable salt, or ester thereof, wherein, M is O, N(H), or CH 2 ; n is 0-4; R 1 is —OR 6 , —NR 6 R 7 or where R 6 and R 7 can be the same or different, each being independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, (C 3 -C 10 )cycloalkyl, (C 3 -C 10 )cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, hydroxyl, amino, arylamino and alkylamino; R 4 and R 5 can be the same or different, each being independently selected from the group consisting of H, alkyl, aryl and (C 3 -C 10 )cycloalkyl; or alternatively R 4 and R 5 together form part of a cyclic 5- to 7-membered ring such that the moiety is represented by where k is 0 to 2; X is selected from the group consisting of: where p is 1 to 2, q is 1-3 and P 2 is alkyl, aryl, heteroaryl, heteroalkyl, (C 3 -C 10 )cycloalkyl, dialkylamino, alkylamino, arylamino or (C 3 -C 10 )cycloalkylamino; and R 3 is selected from the group consisting of: aryl, heterocyclyl, heteroaryl, where Y is O, S or NH, and Z is CH or N, and the R 8 moieties can be the same or different, each R 8 being independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, (C 3 -C 10 )cycloalkyl, aryl, heteroaryl, heterocyclyl, hydroxyl, amino, arylamino, alkylamino, dialkylamino, halo, alkylthio, arylthio and alkyloxy; wherein each of said heteroaryl and said heterocyclyl consist of 4-14 ring atoms, wherein 1 to 4 of said ring atoms are O, N, or S, further wherein each of said heteroaryl and heterocylyl can be monocyclic or bicyclic; heteroalkyl is (C 1 -C 12 ) alkyl, wherein 1-4 of the (C 1 -C 12 ) atoms are replaced by heteroatoms selected from the group consisting of O, N and S.