Patent ID: 7780950

Claim:
A method of monitoring anti-inflammatory or antioxidant actions or both of a therapeutic agent, said method comprising: determining a level of at least one systemic marker indicative of inflammation or oxidation in a bodily sample taken from a subject during or following administration of the therapeutic agent, the systemic marker including at least one of MPO activity, MPO mass, an MPO-generated oxidation product selected from the group consisting of nitrotyrosine, methionine sulphoxide, homocitrulline, and combinations thereof, the bodily sample including at least one of serum, plasma, urine, neutrophils, subpopulation of neutrophils, monocytes or subpopulations monocytes, wherein the level of the systemic marker is determined per unit of the bodily sample when the systemic marker is MPO activity or MPO mass or both, and comparing the level of the systemic marker in the bodily sample with a predetermined value to monitor the anti-inflammatory or antioxidant actions or both of the therapeutic agent, wherein a decrease in the level of the systemic marker in the bodily sample as compared to the predetermined value indicates that the therapeutic agent provides anti-inflammatory or antioxidant actions or both in the subject.