Patent ID: 8324405

Claim:
A compound of formula I: wherein: q is 0, 1, 2, 3, or 4; R 1 is hydroxyl; R 2 is hydrogen; R 3 is selected from the group consisting of hydrogen, deuterium, alkyl, and substituted alkyl; R 4 is selected from the group consisting of hydrogen, deuterium, and methyl; and each R 5 is independently selected from the group consisting of hydrogen, hydroxy, cyano, halo, nitro, acyl, amino, substituted amino, acylamino, sulfonyl, substituted sulfonyl, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, aryl, substituted aryl, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, arylthio, substituted arylthio, heteroarylthio, substituted heteroarylthio, heterocyclicthio, substituted heterocyclicthio, heteroaryl, and substituted heteroaryl; or two R 5 taken together with the carbon atoms to which they are attached form an aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, heteroaryl or substituted heteroaryl; R 10 is —NR 11 R 12 or —OR 13 ; R 11 and R 12 are independently selected from the group consisting hydrogen, alkyl, cycloalkyl-alkylene, (C 3 -C 8 )heterocyclic, aryl, —C(O)(C 1 -C 4 )alkyl, and alkyl-(C 3 -C 8 )cycloalkylene; or R 11 and R 12 taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic or substituted heterocyclic; and R 13 is selected from the group consisting of hydrogen, a cation, and alkyl which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of cycloalkyl, heterocyclic, aryl, and heteroaryl; or a pharmaceutically acceptable salt, single stereoisomer, or mixture of stereoisomers thereof; provided that the compound is not [(4-hydroxy-2-oxo-2H-chromene-3-carbonyl)-amino]-acetic acid.