Patent ID: 7166726

Claim:
A compound of the formula wherein R 1 is independently H or alkyl of 1 to 6 carbons; R 2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br, I, CF 3 , fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons; n is an integer of between 0 and 2; o is an integer between 0 and 3; R 3 is hydrogen, lower alkyl of 1 to 6 carbons, F, Cl, Br or I; R 4 is heteroaryl or (R 5 ) p -heteroaryl where the heteroaryl group is 5-membered or 6-membered and has 1 to 3 heteroatoms selected from the group consisting of O, S, and N; p is an integer having the values of 0–5; R 5 is F, Cl, Br, I, NO 2 , N(R 8 ) 2 , N(R 8 )COR 8 , N(R 8 )CON(R 8 ) 2 , OH, OCOR 8 , OR 8 , CN, COOH, COOR 8 , C 1-10 alkyl, fluoro substituted C 1-10 alkyl, C 2-10 alkenyl having 1 to 3 double bonds, C 2-10 alkynyl having 1 to 3 triple bonds, or a (trialkyl)silyl or (trialkyl)silyloxy group where the alkyl groups independently have 1 to 6 carbons; A is (CH 2 ) q where q is 0–5, C 3-6 branched alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl having 1 or 2 double bonds, or C 2-6 alkynyl having 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR 8 , CONR 9 R 10 , CH 2 OH, CH 2 OR 11 , CH 2 OCOR 11 , CHO, CH(OR 12 ) 2 , CHOR 13 O, COR 7 , CR 7 (OR 12 ) 2 , CR 7 OR 13 O, or Si(C 1-6 alkyl)3; R 7 is C 1-5 alkyl, C 3-5 cycloalkyl, or C 2-5 alkenyl; R 8 is C 1-10 alkyl, C 1-10 (trimethylsilyl)alkyl, or C 5-10 cycloalkyl; R 9 and R 10 are independently hydrogen, C 1-10 alkyl, C 5-10 cycloalkyl, phenyl or R 12 -phenyl; R 11 is C 1-6 alkyl, phenyl, or R 12 -phenyl; R 12 is C 1-6 alkyl; and R 13 is divalent alkyl radical of 2–5 carbons.