Patent ID: 8153651

Claim:
A compound of a formula: or a pharmaceutically acceptable salt thereof, and stereoisomers and tautomers thereof; wherein: W represents O, CR 8a R 8b , or NR 8c ; X represents N, O, CR 8a , CR 8a R 8b , or NR 8c ; Y represents CR 8d R 8e ; at least one of W′, X′, and Y′ represents N and the rest each independently represents CR 8 ; Z represents CR 8 or N; provided that W′, X′ and Y′ are not all N at the same time; R 1 and R 2 each independently represent hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl; R 3 represents hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, acyl, substituted or unsubstituted amino, substituted or unsubstituted alkylamino,substituted or unsubstituted dialkylamino, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; R 4 and R 5 each independently represent hydrogen or substituted or unsubstituted alkyl; R 7 represents (C 1 -C 6 )alkyl; each R 8 independently represents hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, acyl, substituted or unsubstituted amino, substituted or unsubstituted alkylamino,substituted or unsubstituted dialkylamino, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, alkylthio, alkylsulfinyl or alkylsulfonyl; each R 8a , R 8b , R 8d , R 8e and R 8f independently represents hydrogen, halo, hydroxy, or substituted or unsubstituted alkyl; provided that when the dotted bond is a double bond R 8f is absent; R 8c represents hydrogen, or substituted or unsubstituted alkyl; and the dotted bond represents a single or a double bond; provided that i) when W and X both are O, and Y′ is CR 8 ; then at least one of R 3 and R 8 is other than H; and ii) when W and X both are CH 2 , W′ is N, and Y′ is CR 8 ; then at least one of R 3 and R 8 is other than H.