Patent ID: 7282568

Claim:
An isolated human monoclonal antibody which binds to human IL-8, wherein the antibody comprises a human heavy chain variable region comprising CDR1 as set forth in SEQ ID NO 22, CDR2 as set forth in SEQ ID NO 23, and CDR3 sequences and a human light chain variable region comprising CDR1 as set forth in SEQ ID NO 16, CDR2 as set forth in SEQ ID NO 17, and CDR3 sequences, wherein the V L CDR3 domain comprises the amino acid sequence: Gln-Gln-Tyr-X 1 -X 2 -Ser-X 3 -Thr (SEQ ID NO:46), wherein X 1 , X 2 and X 3 each represents a natural amino acid residue, and X 1 is different from Gly, or X 2 is different from Ser, or X 3 is different from Pro and the V H CDR3 domain comprises the amino acid sequence: Asp-X 4 -Val-Gly-X 5 -Phe-Asp-Tyr (SEQ ID NO:47) wherein X 4 is Lys, Arg, or His, and X 5 is Gly, Ala, Val, Leu, or Ile.