Patent ID: 8709384

Claim:
A substantially spherical microsphere comprising: a biocompatible polymeric material comprising polyvinylalcohol, doxorubicin in a concentration of about 10 mg to about 400 mg of doxorubicin per 100 mg of dry microspheres, and a non-ionic contrast agent in a concentration of about 100 mg to about 3200 mg iodine per 100 mg of dry microspheres, wherein the non-ionic contrast agent is selected from at least one of the following: metrizamide, iopamidol, iodixanol, iohexol, ioversol, iopromide, iobitridol, iomeprol, iopentol, iopamiron, ioxilan, iotrolan, iotrol, ioversol, and combinations thereof, wherein the microsphere is swellable in a pharmaceutically acceptable solution and has a diameter of from about 10 μm to about 1000 μm before swelling, wherein the diameter of the microsphere is from about 40 μm to about 2000 μm after swelling, and wherein more than 1% but less than 20% of the loaded doxorubicin is configured to be released from within the microsphere within a period of 72 hours.