Patent ID: 8067473

Claim:
A method for modulating cancer cell growth, comprising contacting the cancer cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor such that the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulate cell growth to a greater extent in comparison to a corresponding cell treated with the topoisomerase inhibitor alone, wherein the E3 ubiquitin ligase inhibitor is a compound having the structure: wherein R 1 and R2 are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic alkyl, aryl, heterocyclic aryl, acyl, alkoxy, amino, carboxyl, nitrile, sulfide, sulfone or sulfonamide, wherein each of the cycloalkyl, heteroclyclic alkyl, aryl, and heterocyclic aryl are optionally substituted with 1 to 3 groups selected from halogen, hydroxyl, amino, nitro, nitrile, sulfide, C 1 -C 6 alkyl, halogenated C 1 -C 6 alkyl, mono- or di-(C1-C6 alkyl) amine, C1-C6 alkoxy, or aryl or heterocyclic aryl; and R 3 , R 4 , R 5 and R 6 , are each independently hydrogen, halogen, amine, amide, hydroperoxy, alkyl, alkoxy, alkenyl, acyl, carboxyl, carboxylate, aryl, heterocyclic aryl; or a salt or an enantiomer of the compound.