Patent ID: 6949549

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof: wherein L is O, S or NR n where R n is H, C 1-6 alkyl or C 3-6 cycloalkyl; X is a pyridyl or 1,2,4-triazolyl ring, which is optionally substituted by R x and/or R y and/or R z , where R x is halogen, R 3 , OR 3 , OCOR 3 , NR 4 R 5 , NR 4 COR 5 , OH, tri(C 1-6 alkyl)silylC 1-6 alkoxyC 1-4 alkyl, CN or R 6 , R y is halogen, R 3 , OR 3 , OCOR 3 , NR 4 R 5 , NR 4 COR 5 , NR 4 R 5 (C 1-6 )alkyl or CN and R z is R 3 , OR 3 or OCOR 3 , providing that when X is a pyridine derivative, the pyridine ring is optionally in the form of the N-oxide; Y is optionally branched C 1-4 alkylene optionally substituted by an oxo group or Y is a group (CH 2 ) j O wherein the oxygen atom is nearest the group X and j is 2, 3 or 4; Z represents a isoxazolyl ring which may be optionally substituted with one or more substituents selected from halogen, R 3 , OR 3 , OCOR 3 , NR 4 R 5 , NR 4 R 5 (C 1-6 )alkyl, NR 4 R 5 CO, NR 4 R 5 CO(C 1-6 )alkyl, CN, cyano(C 1-6 )alkyl or R 6 ; R 3 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-6 )alkyl, cyano(C 1-6 )alkyl, hydroxyC 1-6 alkyl and R 3 is optionally mono, di- or tri-fluorinated; R 4 and R 5 are each independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl or CF 3 or R 4 and R 5 , together with a nitrogen atom to which they are commonly attached, form a 4-7 membered heteroaliphatic ring containing the said nitrogen atom and optionally one other heteroatom selected from O, N and S; and R 6 is C 6-10 aryl, C 6-10 aryl (C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, where heteroaryl is a five-membered aromatic ring containing one, two, three or four nitrogen atoms or one oxygen atom or sulphur atom and optionally one or two nitrogen atoms or a six-membered aromatic ring containing one, two or three nitrogen atoms, and R 6 is optionally substituted by one, two or three substituents independently chosen from halogen atoms and C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 2-4 alkenyloxy and C 2-4 alkynyloxy groups each of which groups is unsubstituted or substituted by one, two or three halogen atoms.