Patent ID: 8309583

Claim:
A compound of formula (I) wherein, a is an integer from 2 to 7 wherein any of the CH 2 groups in this unit can be substituted with alkyl or aryl units that can contain heteroatoms (S, N, O, Cl, F, Br or I); b is an integer from 1 to 7 wherein any of the CH 2 groups in this unit can be substituted with alkyl or aryl units that can contain heteroatoms (S, N, O, Cl, F, Br or I); R 1 is H or (CH 2 ) n , where n is an integer from 1 to 6 or is a CH 2 linker unit that can be further substituted at any CH 2 group in the chain with alkyl or aryl units that can contain heteroatoms (S, N, O, Cl, F, Br or I); W is C(O) or C(S) or (CH 2 ) n , where n is 0 or an integer from 1 to 6; X is NH or (CH 2 ) n , wherein n is 0 or an integer from 1 to 6 or is a CH 2 linker unit that can be further substituted at any CH 2 group in X with alkyl or aryl units that can contain heteroatoms (S, N, O, Cl, F, Br or I); Y is absent or is N, O, S, C(O), C(S), S(O), S(O) 2 , NH or NR′ where R′ is an alkyl or aryl substituent that can contain heteroatoms (S, N, O, Cl, F, Br or I); Z is a derivative of 3 hydroxy-1,2-dimethyl-4(1H)-pyridone), a derivative of 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid) or a carbocycle selected from norbornane, cubane, trishomocubane and adamantane, each of said carbocycle optionally being substituted with at least one substituent, each substituent independently selected from halo, hydroxyl, ═O, C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylthio, polyhalo-C 1-6 alkyl, polyhaloC 1-6 alkyloxy, cyano, nitro, carboxyl, C 1-4 alkyl-SO 2 —, amino, mono- or di(C 1-4 alkyl)amino, C 1-4 alkylcarbonylamino, or —O(CH 2 CH 2 O) 3 CH 2 CH 2 O—; and wherein, the derivative of 3-hydroxy-1,2-dimethyl-4(1H)-pyridone is and the derivative of 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid is or a pharmaceutically acceptable salt thereof.