Patent ID: 7250515

Claim:
A compound of the formula: wherein R 1 is hydrogen, lower alkyl, cyclo lower alkyl, aryloxy-lower alkyl, lower alkoxy, hydroxyl lower alkyl, —NH 2 , —[CH 2 CH 2 O] v R 8 or R 2 —(X) n —X is selected from lower alkylene, cyclo lower alkylene, aryl lower alkylene, carboxy lower alkylene, hydroxy lower alkylene, amido lower alkylene, mono- or di-halo lower alkylene, amino lower alkylene, mono- or di-lower alkyl amino lower alkylene and imido lower alkylene, R 2 is is selected from an aryl ring, cycloalkyl ring containing from 3 to 6 carbon atoms, a 4 to 6 membered heterocycloalkyl ring containing from 3 to 5 carbon atoms and from 1 to 2 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur, and a 5 or 6 membered heteroaromatic ring containing from 1 to 2 hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen; R 5 , R 6 and R 7 are independently selected from the group consisting of hydroxy, lower alkyl sulfone, hydroxy-lower alkyl, hydrogen, lower alkyl, halogen, perfluro lower alkyl, lower alkoxy, amino, mono- or di-lower alkyl amino, or when two of the substituents R 5 , R 6 and R 7 are substituted on adjacent carbon atoms on ring these two substituents can be taken together with their adjacent, attached carbon atoms to form an aryl ring, a 3 to 6 membered cyclic lower alkyl ring, a 4 to 6 membered heterocycloalkyl ring or a 4 to 6 membered heteroaromatic ring, said heterocycloalkyl ring and said heteroaromatic ring containing from 1 to 2 hetero atoms selected from the group consisting of oxygen, nitrogen or sulfur; is selected from an aryl ring, a cycloalkyl ring containing from 3 to 6 carbon atoms, a 4 to 6 membered heterocyclic alkyl ring containing from 1 to 2 hetero atoms selected from the group consisting of a oxygen, sulfur and nitrogen or a 5 to 6 numbered heteroaromatic right containing from 1 to 2 hetro atoms selected from the group consisting of oxygen, sulfur and nitrogen; R 8 , R 11 , R 15 , R 16 , R 17 , and R 18 are independently hydrogen or lower alkyl; R 10 is lower alkyl; R 12 is O or S; R 14 is selected from hydroxyalkyl, lower alkyl, cycloalkyl, haloalkyl, perfluoroalkyl and protected hydroxyalkyl; x, n and k are integers from 0 to 1; z is an integer from 0 to 3; y is an integer from 1 to 3; and v is an integer from 1 to 6, or pharmaceutically acceptable salts thereof.