Patent ID: 8519103

Claim:
A modified factor VII (FVII) polypeptide, comprising amino acid replacements at positions corresponding to positions 128, 129, 286 and 298 in a FVII polypeptide having the sequence of amino acids set forth in SEQ ID NO:3, wherein: the amino acid replacement at the position corresponding to 128 is Asn (N), position 129 is Ala (A), position 286 is Arg (R), and position 298 is Gln (Q); the amino acid sequence of the modified FVII polypeptide has at least 90% sequence identity to a polypeptide of any of SEQ ID NOS.:1-3; the corresponding positions in the modified FVII polypeptide are identified by alignment of the amino acid sequence of the modified FVII polypeptide with the amino acid sequence set forth in SEQ ID NO: 3; and the modified FVII polypeptide, when in its activated form, exhibits procoagulant activity.