Patent ID: 8022246

Claim:
A compound, or pharmaceutically acceptable salt thereof, of Formula IV: wherein: X 21 , X 22 , X 23 , X 24 , X 25 , and X 27 are each independently H, OH, oxo, or Y; wherein for oxo: one of X 21 and X 25 ; X 22 ; X 23 ; or X 24 and X 27 taken together can independently be oxo; Y is B-C-D or C-B-D or C-B-C-D, any of which may be attached to a ring carbon to form a fused ring; B is selected from the group consisting of null, carbonyl, carboxy, ether, sulfanyl, amino, —NHC(O)— and —C(O)NH—, any of which is optionally substituted; C is selected from the group consisting of null, alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, arylalkyl, and arylalkenyl, any of which is optionally substituted, and which may be attached to a ring carbon so as to form a fused ring; and D is selected from the group consisting of null, carboxy, benzoic acid, hydroxybenzoic acid, SO 3 H, PO 3 , NO 3 , NO 2 , NO, amino, hydroxyl; wherein X 26 is carboxy or carboxy-terminated group; wherein B, C and X 26 are optionally substituted with one or more substituents independently selected from lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower heteroalkyl, lower heterocycloalkyl, lower haloalkyl, lower haloalkenyl, lower haloalkynyl, lower perhaloalkyl, lower perhaloalkoxy, lower cycloalkyl, phenyl, aryl, aryloxy, lower alkoxy, lower haloalkoxy, oxo, lower acyloxy, carbonyl, carboxyl, lower alkylcarbonyl, lower carboxyester, lower carboxamido, cyano, hydrogen, halogen, hydroxy, amino, lower alkylamino, arylamino, amido, nitro, thiol, lower alkylthio, arylthio, lower alkylsulfinyl, lower alkylsulfonyl, arylsulfinyl, arylsulfonyl, arylthio, sulfonate, sulfonic acid, trisubstituted silyl, —N3, —SH, —SCH3, —C(O)CH3, —CO2CH3, —CO2H, pyridinyl, thiophene, furanyl, lower carbamate, and lower urea.