Patent ID: 8916705

Claim:
A compound that directly activates procaspase-3 upon contacting procaspase-3, wherein the compound is a novel compound of Formula I: wherein R 1 is a substituted (aryl)methylene, or (aryl)methine wherein the methine carbon is optionally substituted with phenyl; n is 2; each R 2 is methyl, ethyl or t-butyl or two R 2 groups form an ortho-fused benzo group; and wherein R 1 is substituted (aryl)methylene, the (aryl)methylene substitution comprises one or more nitro, sulfonamide, azidomethylene, phenoxy, phenyl, trifluoromethyl, trifluoromethoxy, phenylsulfonylmethylene, benzoyl, or a combination thereof; or a pharmaceutically acceptable salt or solvate thereof.