Patent ID: 8099262

Claim:
A computer-based diagnostic method for estimating for a patient the treatment response of a disease caused by a pathogen to a drug, the method comprising: a) inputting data related to the genotype exhibited by a disease causing pathogen to a computer apparatus; b) determining, by the computer apparatus, the fold change resistance value of the pathogen infecting the patient; c) determining, by the computer apparatus, a clinical cut-off value which is the fold change resistance value at which a clinically relevant variation of clinical response is observed; wherein the clinical cut-off value is established by modeling the clinical response of a population of patients treated with the drug to the disease caused by the pathogen as a function of the fold change resistance of the pathogen infecting the patients; d) comparing, by the computer apparatus, the fold change resistance value of the pathogen infecting the patient to the clinical cut-off value; e) calculating, by the computer apparatus, the predicted treatment response of a disease caused by the pathogen, and f) outputting the results of the computer-generated estimate of the treatment response.