Patent ID: 7432277

Claim:
A compound of the Formula I: wherein: A is independently —O—, —S— or —NR 2 —; Q is V or VN(R)V; wherein V is independently an aliphatic, a heteroaliphatic, an aryl or a 5-14 membered heteroaryl moiety, having 1-4 heteroatoms selected from nitrogen, oxygen and sulfur; J is: each occurrence of X is independently H, —NR 2 R 5 , —OR 2 or halo; one of R 7a and R 7b is H and the other is H, halo, —R A , —OR A , —SR A , —OC(O)R A , —OC(O)NR A R B , —NR A R B , —NR B C(O)R A , —NR B C(O)OR A , —NR B SO 2 R A , —OC(O)OR A , —NR B C(O)NR A R B or —NR B SO 2 NR A R B ′; or R 7a and R 7b , taken together, are H in the tetraene moiety: R A is R 2 , R B is OH or R 2 ; R, R 2 and R 5 are independently selected from H, an aliphatic, a heteroaliphatic, an aryl and a 5-14 membered heteroaryl moiety having 1-4 heteroatoms selected from nitrogen, oxygen and sulfur; R 28 is hydrogen, —COVH or COAQJ; and n is 1 or 2; wherein each aliphatic moiety contains 1-8 contiguous aliphatic carbon atoms, each heteroaliphatic moiety is an aliphatic moiety which contains an O, S, N, P or Si atom in place of one or more carbon atoms; and each of the foregoing aliphatic and heteroaliphatic moieties is independently branched or unbranched, or cyclic or acyclic, and unsubstituted or substituted with one or more groups selected from halogen, —YR 2 , —Y—C(═O)R 2 , —NR 2 C(═O)R 5 , —NR 2 C(═O)NR 5 , —NR 2 C(═O)OR 5 , —NR 2 C(═NH)NR 5 , —Y—C(═O)OR 2 , —Y—C(═O)NR 2 R 5 , —Y—C(═NR 2 )NR 2 R 5 , —COCOR 2 , —C(═O)(CH 2 ) r C(═O)R 2 , J, —CN, —S(═O)R 2 , —SO 2 R 2 , —SO 2 NR 2 R 5 , —NO 2 , —NR 5 SO 2 R 2 , —OSO 2 R 2 , —NR 5 SO 2 NR 2 R 5 , ═O, ═S, ═NR 2 , ═NNR 2 R 5 , ═NNHC(O)R 2 , ═NNHCO 2 R 2 , and ═NNHSO 2 R 2 , wherein Y is selected from a bond, —O—, NR 5 , and —S—, r is an integer of 1 to 4; and each aryl or heteroaryl moiety is independently unsubstituted or substituted with one or more groups selected from halogen, —YR 2 , —Y—C(═O)R 2 , —NR 2 C(═O)R 5 , —NR 2 C(═O)NR 5 , —NR 2 C(═O)OR 5 , and —NR 2 C(═NR 2 )NR 5 , —Y—C(═O)OR 2 , —Y—C(═O)NR 2 R 5 , —Y—C(═NR 2 )NR 2 R 5 , —COCOR 2 , —C(═O)(CH 2 ) r C(═O)R 2 , J, —CN, —S(═O)R 2 , —SO 2 R 2 , —SO 2 NR 2 R 5 , —OSO 2 R 2 , —NO 2 , —NR 5 SO 2 R 2 and —NR 5 SO 2 NR 2 R; wherein Y is selected from a bond, —O—, NR 5 and —S—, r is an integer of 1 to 4.