Patent ID: 8519107

Claim:
An isolated antibody or fragment thereof that binds specifically to human IL-17A, comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH region comprises the HCDR1, HCDR2 and HCDR3 having the amino acid sequences as shown in SEQ ID NOs:25, 46 and 61, respectively; and the VL region comprises the LCDR1, LCDR2, and LCDR3 having the amino acid sequences as shown in SEQ ID NOs:3, 6 and 22, respectively; and wherein in SEQ ID NO:46, Xaa1 may be Ala, Gly, Thr or Val; Xaa3 may be Asn or Ser; Xaa4 may be Gly, Met, Lys, Ile, Leu or His; Xaa5 may be Leu, Asp, Ala, His, Thr, Gly or Ser; Xaa6 may be Gly or Ser; Xaa7 may be Thr, Gly, Tyr or Asp; Xaa8 may be His, Trp, Tyr or Phe; Xaa9 may be Lys, Thr or Ile; and Xaa10 may be Tyr, Phe or Asn; in SEQ ID NO:61, Xaa may be Met, Leu or Thr; and in SEQ ID NO:22, Xaa is Met, Leu, Thr or Tyr.