Patent ID: 8263629

Claim:
A compound of the formula (I′): or a pharmaceutically acceptable salt or tautomer thereof, wherein: R 1 is C 1-7 alkyl; for each occurrence, R 2 is independently C 1-7 alkyl, NO 2 , CN, halo, C 3-7 cycloalkyl, hydroxy, C 1-7 alkoxy, halo-C 1-7 alkyl, NR b R c , C 6-10 aryl, heteroaryl or heterocyclyl; wherein R b and R c for each occurrence, are independently H or C 1-7 alkyl; R 3 is A 2 -R 4 ; R 4 is C 6-10 aryl or a heteroaryl, which can be monocyclic or bicyclic and which can be optionally substituted with one or more substituents independently selected from hydroxy, hydroxy-C 1-7 alkyl, NR b R c , nitro, C 1-7 alkoxy, halo, C 1-7 alkyl, halo-C 1-7 alkyl, C 2-7 alkenyl, C 6-10 aryl, heteroaryl, —C(O)C 1-7 alkyl, —NHS(O) 2- C 1-7 alkyl, —SO 2 C 1-7 alkyl and benzyl; R 5 is H, halo, hydroxy, C 1-7 alkoxy, halo, C 1-7 alkyl or halo-C 1-7 alkyl; and X is OH, —O—C 1-7 alkyl, —NR b R c , —NHS(O) 2 —C 1-7 alkyl, —NHS(O) 2 -benzyl or —O—C 6-10 aryl; wherein alkyl is optionally substituted with one or more substituents independently selected from the group consisting of aryl, heteroaryl, heterocyclyl, —C(O)NH 2 , —C(O)NH—C 1-6 alkyl, and —C(O)N(C 1-6 alkyl) 2 ; A 2 is a bond or a linear or branched C 1-7 alkylene which is optionally substituted with one or more substituents independently selected from the group consisting of halo, C 1-7 alkoxy, hydroxy, O-Acetate and C 3-7 cycloalkyl; n is 0, 1, 2, 3, 4 or 5; wherein each heteroaryl is a monocyclic or bicyclic aromatic ring comprising 5-10 ring atoms selected from carbon atoms and 1 to 5 heteroatoms, and each heterocyclyl is a monocyclic saturated or partially saturated but non-aromatic moiety comprising 4-7 ring atoms selected from carbon atoms and 1-5 heteroatoms, wherein each heteroatom of a heteroaryl or a heterocyclyl is independently selected from O, N and S.