Patent ID: 8501755

Claim:
A compound of formula (I) wherein m is 0, 1, or 2; n is 0, 1, 2, or 3; q is 0 or 1; R 1 represents H, (C 1 -C 4 )alkyl, or halo; either (a) R 2 is selected from the group consisting of H, —CN, halo, (C 1 -C 4 )alkyl, —O(C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, and (C 2 -C 4 )alkynyl ; and R 3 is selected from the group consisting of H, halo, —CN, (C 1 -C 4 )alkyl, ethynyl, propargyl, and *—O(CH 2 ) p Ar, wherein p is 0, 1, or 2, and Ar represents phenyl, pyridyl, thiazolyl, thiophenyl, or pyrazinyl, and wherein Ar optionally bears 1 or 2 substituents selected from the group consisting of (C 1 -C 4 )alkyl and halo; or (b) R 2 and R 3 are joined, and taken together with the carbon atoms to which they are attached, form a fused five- or six-membered saturated or unsaturated carbocycle, or form a fused heterocycle in which the combined R 2 and R 3 groups are represented by the formula wherein Ar′ and Ar″ each represents phenyl, pyridyl, thiazolyl, thienyl, or pyrazinyl and wherein Ar′ and Ar″ each optionally bears 1 or 2 substituents selected from the group consisting of (C 1 -C 4 )alkyl and halo; R 4 is selected from the group consisting of H, —CN, (C 1 -C 4 )alkyl, —O(C 1 -C 4 )alkyl, halo, (C 2 -C 4 )alkenyl, and (C 2 -C 4 )alkynyl; R 5 represents H or halo; when n is 0, R 7 is H; when n is 1, 2 or 3, R 7 represents: H; hydroxyl; —NR 12 R 13 wherein R 12 represents H or (C 1 -C 6 )alkyl which optionally bears 1 or 2 hydroxyl or mono- or di- ((C 1 -C 4 )alkyl)amino groups; and R 13 represents H, (C 1 -C 6 )alkyl, or (C 3 -C 6 )cycloalkyl, said alkyl and cycloalkyl groups optionally bearing 1 or 2 hydroxyl or mono- or di- ((C 1 -C 4 )alkyl)amino groups; in which R 14 is hydroxyl, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, or mono-or di- ((C 1 -C 4 )alkyl)amino, each alkyl substituent in turn optionally bearing a hydroxyl substituent; which optionally bears 1 or 2 hydroxyl, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, or mono- or di- ((C 1 -C 4 )alkyl)amino substituents, each alkyl substituent in turn optionally bearing a hydroxyl substituent; and wherein r is 0, 1, or 2; which optionally bears 1 or 2 (C 1 -C 4 )alkyl substituents, each alkyl substituent in turn optionally bearing a hydroxyl substituent; and wherein X represents O, S(O) s , or NR 15 , in which s is 0, 1 or 2; and R 15 represents (C 1 -C 4 )alkyl; or when n =2, R 7 and R 9 are optionally joined, and taken together with the carbon atoms to which they are attached and the intervening carbon atoms, form a ring of structure wherein R 16 represents (C 1 -C 4 )alkyl; R 8 represents halo, hydroxyl, or (C 1 -C 4 )alkyl; and either (a) R 9 represents H or —CH 2 —Y, wherein Y is mono- or di- ((C 1 -C 4 )alkyl)amino, or and R 10 represents H; or (b) R 9 and R 10 are taken together to form a bond, resulting in an acetylenic linkage; or a pharmaceutically acceptable salt thereof.