Patent ID: 8664381

Claim:
A process for the synthetic preparation of a crude Amorolfine hydrochloride having purity higher than 90% and containing <5% Bepromoline hydrochloride and <3% Fenpropimorf, comprising: I. preparing Amorolfine base by alkylating Bepromoline with: 2-chloro-2-methylbutane in presence of a Friedel-Crafts catalyst selected from the group consisting of FeCl 3 and AlCl 3 ; or 2-methyl-2-butanol in presence of concentrated sulphuric acid as Friedel-Crafts catalyst; at a temperature T higher than −20° C. and lower than 0° C.; and II. preparing crude Amorolfine hydrochloride from the Amorolfine base prepared in I, by treating said Amorolfine base with hydrochloric acid.