Patent ID: 8389533

Claim:
A compound of Formula IA, IB, IC, or ID or an enantiomer, diastereomer, or salt thereof wherein t is 0; v is 0, 1, 2, or 3; R 1 is —Y—R a wherein Y is selected from phenyl, pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, or pyradizinyl any of which may be optionally independently substituted with one or more R x groups as allowed by valence; and R a is selected from piperazinyl, piperidinyl, morpholinyl, or pyrrolidinyl any of which may be optionally substituted with one or more R x group as allowed by valence; M is —CR d R e —, —O—, —S(O) n —, or —NHR 3 —; R b , R c , R d and R e are each independently H or R x , or alternatively R b and R d on adjacent carbon ring atoms may optionally combine to form a double bond as allowed by valence, and R d and R e on adjacent carbon ring atoms may optionally combine to form a double bond as allowed by valence; R 3 and R 4 at each occurrence are independently (i) hydrogen or (ii) alkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, or heteroarylalkyl; or R 3 and R 4 together with the nitrogen atom to which they are attached may combine to form a heterocyclo ring; R 5 is (i) hydrogen or (ii) alkyl, alkenyl, alkynyl cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, or heteroarylalkyl; R x at each occurrence is independently, halo, cyano, nitro, oxo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkyl, -(alkylene) m -OR 5 , -(alkylene) m -S(O) n R 5 , -(alkylene) m -NR 3 R 4 , -(alkylene) m -C(═O)R 5 , -(alkylene) m -C(═S)R 5 , -(alkylene) m -C(═O)OR 5 , -(alkylene) m -OC(═O)R 5 , -(alkylene) m -C(═S)OR 5 , -(alkylene) m -C(═O)NR 3 R 4 , -(alkylene) m -C(═S)NR 3 R 4 , -(alkylene) m -N(R 3 )C(═O)NR 3 R 4 , -(alkylene) m -N(R 3 )C(═S)NR 3 R 4 , -(alkylene) m -N(R 3 )C(═O)R 5 , -(alkylene) m -N(R 3 )C(═S)R 5 , -(alkylene) m -OC(═O)NR 3 R 4 , -(alkylene) m -OC(═S)NR 3 R 4 , -(alkylene) m -SO 2 NR 3 R 4 , -(alkylene) m -N(R 3 )SO 2 R 5 , -(alkylene) m -N(R 3 )SO 2 NR 3 R 4 , -(alkylene) m -N(R 3 )C(═O)OR 5 , -(alkylene) m -N(R 3 )C(═S)OR 5 , or -(alkylene) m -N(R 3 )SO 2 R 5 ; n is 0, 1 or 2; m is 0 or 1; and p and q are independently 0, 1 or 2.