Patent ID: 7427592

Claim:
A method for treating a mammal having a Factor VIIa/tissue factor-related (FVIIa/TF-related) disease or disorder, comprising administering to a mammal in need thereof an amount of a conjugate effective to treat said disease or disorder, the conjugate comprising: a recombinant Factor VII (FVII) or Factor VIIa (FVIIa) polypeptide variant having clotting activity comprising an amino acid sequence which (a) differs from the sequence of human Factor VII (hFVII) or human Factor VIIa (hFVIIa) shown in SEQ ID NO:1 in no more than 10 amino acid residues and (b) comprises an introduced N-glycosylation site relative to SEQ ID NO:1 comprising the substitution T106N, wherein amino acid residue positions are numbered according to SEQ ID NO:1; and a sugar moiety covalently attached to the introduced N-glycosylation site.