Patent ID: 8592403

Claim:
A compound of formula (I): or pharmaceutically acceptable salts and solvates thereof, wherein: n is 0 or 1; R 1 is —(C 1 -C 4 )alkyl, or Het 1 ; R 2 is phenyl or pyridyl, wherein said phenyl or pyridyl is optionally substituted by one to three substituents independently selected from halo, CN, —(C 1 -C 4 )alkyl and —(C 1 -C 4 )alkoxy wherein the —(C 1 -C 4 )alkyl and —(C 1 -C 4 )alkoxy groups are optionally substituted with 1 to 3 fluorine atoms; R 3 is phenyl or pyridyl, wherein said phenyl or pyridyl is optionally substituted by one to three substituents independently selected from halo, CN, —(C 1 -C 4 )alkyl and —(C 1 -C 4 )alkoxy wherein the —(C 1 -C 4 )alkyl and —C 1 -C 4 )alkoxy groups are optionally substituted with 1 to 3 fluorine atoms; either L is —CO— and R 4 is —(C 1 -C 4 )alkyl, —(C 1 -C 4 )alkoxy, —(C 3 -C 6 )cycloalkyl, —(C 1 -C 2 )alkyl(C 3 -C 6 )cycloalkyl, —(C 1 -C 2 )alkyl(C 1 -C 4 )alkoxy, —NH 2 , —NH(C 1 -C 4 )alkyl, —N[(C 1 -C 4 )alkyl] 2 or Het 2 , wherein the —(C 1 -C 4 )alkyl group is optionally substituted with 1 to 3 fluorine atoms and wherein the —(C 3 -C 6 )cycloalkyl group is optionally substituted with 1 to 3 fluorine atoms or —(C 1 -C 4 )alkyl groups; or L is —SO 2 — and R 4 is —(C 1 -C 4 )alkyl; —(C 3 -C 6 )cycloalkyl, —(C 1 -C 2 )alkyl(C 3 -C 6 )cycloalkyl, —(C 1 -C 2 )alkyl(C 1 -C 4 )alkoxy, —NH 2 , —NH(C 1 -C 4 )alkyl, —N[(C 1 -C 4 )alkyl] 2 , or Het 2 ; Het 1 is (i) a 6-membered ring containing one or 2 N atoms, wherein the ring is either aromatic, or contains 2 double bonds in the ring and a ═O substituent, which ring is optionally substituted by one to three substituents independently selected from halo, CN, and —(C 1 -C 4 )alkyl; (ii) a 6-membered aromatic ring containing one or 2 N atoms fused at the 3,4-positions, relative to the attachment to the pyrrolidine ring, to a 5-membered aromatic ring containing one to three further N atoms; or (iii) tetrahydropyranyl; Het 2 is (i) a 5-membered aromatic ring containing one or 2 N atoms and a further optional O atom, S atom or N atom, (ii) a 4- to 6-membered saturated ring containing one N atom; or (iii) a 6-membered saturated ring containing one O atom and a further optional N atom.