Patent ID: 7125975

Claim:
A compound comprising a plurality of linked nucleosides, wherein: at least one of the nucleosides is a 2′-deoxy′-2′-fluoro, 2′-O—C 1 –C 20 -alkyl, 2′-O—C 2 –C 20 -alkenyl, 2′-O—C 2 –C 20 -alkynyl, 2′-S—C 1 –C 20 -alkyl, 2′-S—C 2 –C 20 -alkenyl, 2′-S—C 2 –C 20 -alkynyl, 2′-NH—C 1 –C 20 -alkyl, 2′-NH—C 2 –C 20 -alkenyl, or 2′-NH—C 2 –C 20 -alkynyl nucleoside; and at least one of the nucleosides is a 5′-O-terminal nucleoside having a non-aromatic lipophilic molecule linked to the 5′-O-position of the nucleoside, provided that the compound does not include sulfamate or sulfamide internucleotide linkages.