Patent ID: 6964974

Claim:
A compound of formula (I) wherein U is a lone pair; V is —C≡C—; m and n are each integers from 0 to 7 and m+n is 0 to 7; W is SO 2 , or SO 2 NR 1 , A 1 is H, lower-alkyl or lower-alkenyl, A 2 is cycloalkyl, cycloalkyl-lower-alkyl, lower-alkenyl, lower-alkynyl or lower-alkyl optionally substituted with hydroxy, lower-alkoxy or lower-alkoxy-carbonyl, or A 1 and A 2 bond together to form —A 1 —A 2 —, wherein —A 1 —A 2 — is lower-alkylene or lower-alkenylene, optionally substituted by R 2 , and one —CH 2 — group of —A 1 —A 2 — is optionally replaced by NR 3 , S, or O; A 3 and A 4 are independently hydrogen or lower-alkyl; A 5 is lower-alkyl optionally substituted with halogen, lower-alkenyl, lower-alkoxy-carbonyl-lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, aryl, aryl-lower-alkyl, heteroaryl, or heteroaryl-lower-alkyl; R 2 is lower-alkyl, hydroxy, hydroxy-lower-alkyl, or N(R 4 ,R 5 ); R 1 , R 3 , R 4 and R 5 are independently hydrogen or lower-alkyl; and When A 1 is not bonded to A 2 , A 1 and A 3 optionally bond together to form —A 1 —A 3 —, wherein —A 1 —A 3 — is lower-alkylene or lower-alkenylene, optionally substituted by R 2 , and one —CH 2 —group of —A 1 —A 3 — is optionally replaced by NR 3 , S, or O; or pharmaceutically acceptable esters of the compounds of formula (I).