Patent ID: 6864240

Claim:
A compound of formula 1 wherein: A is wherein D is chosen from aryl having 5 to 6 atoms; heteroaryl having 5 to 6 atoms where 1 or 2 heteroatoms are selected from N, O, and S; fused aryl of 8 to 14 atoms; fused heteroaryl of 8 to 14 atoms where 1, 2, or 3 heteroatoms are selected from N, O, and S; mono or fused cycloalkyl having 5 to 12 carbon atoms; and mono or fused heterocycloalkyl having 5 to 12 carbon atoms where 1, 2, or 3 heteroatoms are selected from N, O, and S; biaryl, diaryl ether; diarylketone, and phenyl (C 1 -C 8 ) alkyloxyaryl; and wherein E is a divalent group chosen from carbonyl, sulfonyl, C 1 -C 3 alkylene, —X—(C 1 -C 3 ) alkylcarbonyl wherein X is chosen from N, O and S, or E is merely a bond; and D may optionally be substituted with up to two groups chosen from OH, C 1 -C 3 alkyl; C 1 -C 6 alkylacylamino, C 1 -C 6 alkylacyloxy, C 1 -C 6 alkyloxy, C 1 -C 6 alkylthioxy, amido, NH 2 , mono and di(C 1 -C 6 alkyl and phenyl) amino, carbamyl, benzamides, carbamic acid esters, carboxyl, carboxy(C 2 -C 5 )alkyloxy, N-heterocyclylacyl, C 1 -C 3 alkylsulfonyl, sulfonamide and C 1 -C 3 alkylsulfonamide; B is selected from —OH; C 1 -C 6 alkyl or C 1 -C 6 alkyl amino, di(C 1 -C 6 alkyl)amino, C 1 -C 6 alkyloxy, N-heterocyclic and each n′ is independently 0, 1 or 2; m is 0, 1, 2 or 3; and G is NH or O; J is selected from the group consisting of aryl having a 5 to 6 membered ring; aryl having a 5 to 6 membered ring with 1, or 2 heteroatoms selected from N, O, and S; fused aryl rings of 8 to 14 atoms; fused aryl rings of 8 to 14 atoms with 1, 2, or 3 heteroatoms selected from N, O, and S; mono or fused ring cycloalkyl having 5 to 12 carbon atoms; and mono or fused ring heterocyclic having 5 to 12 carbon atoms with 1, 2, or 3 heteroatoms chosen from the group consisting of N, O, and S; each K is chosen from OH, C 1 -C 3 alkyl; C 1 -C 6 alkylacylamino, C 1 -C 6 alkylacyloxy, C 1 -C 6 alkyloxy, C 2 -C 6 alkylthioxy, amido, NH 2 , mono and di(C 1 -C 6 alkyl and phenyl) amino, carbamyl; phenyl amides, carbamates, carboxyl and carboxy(C 2 -C 5 )alkyloxy; R1 is straight or branched chain C 1 -C 5 alkanyl or C 2 -C 5 alkenyl; R2 is C 1-5 straight or branched chain alkanyl or alkenyl; methylthiomethyl; aryl or arylalkyl or heteroaryl or heteroarylalkyl wherein any of the above are optionally substituted with up to 2 of C 1-3 alkyl, trifluoromethyl or halogen, or a stereoisomer, hydrate or pharmaceutically acceptable salts thereof.