Patent ID: 8835468

Claim:
A method of modulating CCR9 function in a cell, comprising contacting the cell with a CCR9 modulating amount of a compound, salt, or N-oxide of formula (I): where Ar 1 is a substituted or unsubstituted C 6-10 aryl or substituted or unsubstituted 5- to 10-membered heteroaryl; each having 0 to 5 substituents selected from the group consisting of halogen, substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted C 2-8 alkenyl, substituted or unsubstituted C 2-8 alkynyl, —CN, —NO 2 , ═O, —C(O)R 3 , —CO 2 R 3 , —C(O)NR 3 R 4 , —OR 3 , —OC(O)R 3 , —OC(O)NR 3 R 4 , —NR 5 C(O)R 3 , —NR 5 C(O)NR 3 R 4 , —NR 3 R 4 , —NR 5 CO 2 R 3 , —NR 5 S(O) 2 R 3 , —SR 3 , —S(O)R 3 , —S(O) 2 R 3 , —S(O) 2 NR 3 R 4 , substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, and substituted or unsubstituted 3- to 10-membered heterocyclyl; A is N or CR 4 ; X 1 X 2 X 3 are selected from the group consisting of: N—N═N C═N—N(R 5 ) N—C(R 6 )═N N—N═C(R 7 ) N—C(R 6 )═C(R 7 ) C═N—C(R 7 ) C═C(R 6 )—N(R 5 ) R 1 is hydrogen or C 1-8 alkyl; each R 2 , R 3 , R 4 , R 6 and R 7 , when present, are independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted C 2-8 alkenyl, substituted or unsubstituted C 2-8 alkynyl, —CN, ═O, —NO 2 , —OR′, —OC(O)R′, —CO 2 R′, —C(O)R′, —C(O)NR″R′, —OC(O)NR″R′, —NR′″C(O)R′, —NR′″C(O)NR″R′, —NR″R′, —NR′″CO 2 R′, —SR′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR″R′, —NR″S(O) 2 R′, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl and substituted or unsubstituted 3- to 10-membered heterocyclyl; or R 2 and R 3 together with the atoms which they substitute form a substituted or unsubstituted 5-, 6-, or 7-membered ring; each R 5 is independently selected from group consisting of hydrogen, substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted C 2-8 alkenyl, substituted or unsubstituted C 2-8 alkynyl, —CO 2 R′, —C(O)R′, —C(O)NR″R′, —S(O)R′, —S(O) 2 R′, —S(O) 2 NR″R′, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, and substituted or unsubstituted 3- to 10-membered heterocyclyl; and R′, R″ and R′″ are each independently hydrogen or unsubstituted C 1-4 alkyl; or R′ and R″ together with the atoms which they substitute form a substituted or unsubstituted 5-, 6-, or 7-membered ring.