Patent ID: 8026360

Claim:
A method of inhibiting human stearoyl-CoA desaturase (hSCD) activity comprising contacting a source of hSCD with a compound of formula (Ia): wherein: x and y are each 1; G is —C(R 4 )═C(R 4 )—; L and M are both —N═; W is —N(R 1 )C(O)—; R 1 is hydrogen; R 2 is selected from the group consisting of C 7 -C 12 alkyl, C 2 -C 12 alkenyl, C 7 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl, C 2 -C 12 alkoxyalkyl, C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl, aryl, C 13 -C 19 aralkyl, C 3 -C 12 heterocyclyl, C 3 -C 12 heterocyclylalkyl, C 1 -C 12 heteroaryl, and C 3 -C 12 heteroarylalkyl; R 3 is selected from the group consisting of C 3 -C 12 heterocyclyl, C 1 -C 12 heteroaryl and aryl optionally substituted by one or more substituents selected from the group consisting of alkyl, alkenyl, halo, haloalkyl, haloalkenyl, cyano, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, —R 15 —OR 14 , —R 15 —OC(O)—R 14 , —R 15 —C(O)R 14 , —R 15 —C(O)OR 14 , —R 15 —C(O)N(R 14 ) 2 , —R 15 —N(R 14 )C(O)R 16 , —R 15 —N(R 14 )(S(O) t R 16 ) (where t is 1 or 2), —R 15 —S(O) t OR 16 (where t is 1 or 2), —R 15 —S(O) t R 16 (where t is 0, 1 or 2), and —R 15 —S(O) t N(R 14 ) 2 (where t is 1 or 2) where each R 14 is independently hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; each R 15 is independently a direct bond or a straight or branched alkylene or alkenylene chain; and each R 16 is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl, and where each of the above optional substituents is unsubstituted; each R 4 is hydrogen; and R 5 R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are each hydrogen; provided that R 2 is not C 5 -C 10 pyrazinylalkyl, pyridinonyl, pyrrolidinonyl, methylimidazolyl or phenyl substituted with amino; as a stereoisomer, enantiomer or tautomer thereof; or as a pharmaceutically acceptable salt thereof.