Patent ID: 8207381

Claim:
A compound of Formula (I): wherein: R 1 is (C 1 -C 20 )alkyl, (C 2 -C 20 )alkenyl, or (C 2 -C 20 )alkynyl, which (C 1 - 20 )alkyl, (C 2 -C 20 )alkenyl, or (C 2 -C 20 )alkynyl, is substituted with one or more groups independently selected from halo, hydroxy, mercapto, (C 1 -C 20 )alkoxy, (C 2 -C 20 )alkenyloxy, (C 2 -C 20 )alkynyloxy, aryloxy, heteroaryloxy, (C 3 -C 20 )cycloalkyloxy, heterocyclyloxy, (C 1 -C 20 )alkylthio, (C 2 -C 20 )alkenylthio, (C 2 -C 20 )alkynylthio, carboxy, (C 2 -C 20 ) alkenyloxycarbonyl, (C 2 -C 20 )alkynyloxycarbonyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, NR a R b , (C 2 -C 20 )alkynoyloxy, and arylcarbonyloxy; R 2 is CF 2 Br, CF 2 Cl, CFBr 2 , CFCl 2 , CBr 3 , CF(R e )Br, CF 2 I, CF(R e )I or CCl 3 ; each R a and R b is independently H, (C 1 -C 20 )alkyl, (C 1 -C 20 )alkanoyl, (C 2 -C 20 )alkenylcarbonyl, (C 2 -C 20 )alkynylcarbonyl, (C 1 -C 20 )alkoxy, (C 2 -C 20 )alkenyloxy, (C 2 -C 20 )alkynyloxy, or aryl-(C 1 -C 20 )alkoxycarbonyl; and R e is (C 1 -C 20 )alkyl, (C 1 -C 20 )alkanoyl, (C 2 -C 20 )alkenylcarbonyl, (C 2 -C 20 )alkynylcarbonyl, (C 1 -C 20 )alkoxy, (C 2 -C 20 )alkenyloxy, or (C 2 -C 20 )alkynyloxy; wherein each aryl, heteroaryl, heterocyclyl, aryloxy, heteroaryloxy, arylcarbonyloxy or heteroarylcarbonyloxy of R 1 is optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, mercapto, carboxy, (C 1 -C 20 )alkyl, (C 2 -C 20 )alkenyl, (C 2 -C 20 )alkynyl, (C 1 -C 20 )alkoxy, (C 2 -C 20 )alkenyloxy, (C 2 -C 20 )alkynyloxy, (C 1 -C 20 )alkylthio, (C 2 -C 20 )alkenylthio, (C 2 -C 20 )alkynylthio, (C 1 -C 20 )alkoxycarbonyl, (C 2 -C 20 )alkenyloxycarbonyl, (C 2 -C 20 )alkynyloxycarbonyl, aryl, heteroaryl, aryl(C 1 -C 20 )alkyl, heteroaryl(C 1 -C 20 )alkyl, aryl(C 2 -C 2 o)alkenyl, aryl(C 2 -C 20 )alkynyl, heteroaryl(C 2 -C 20 )alkenyl, heteroaryl(C 2 -C 20 )alkynyl, (C 1 -C 20 )alkanoyloxy, (C 2 -C 20 )alkenoyloxy, (C 2 -C 20 )alkynoyloxy; or a salt thereof; provided the compound is not 4-bromo-4,4-difluorobut-2-ynoic acid or 1-bromo-1,1-difluoro-non-2-yn-4-ol.