Patent ID: 7482373

Claim:
A method of decreasing ion flow through Ca 2+ activated small conductance potassium (SK) channels in a cell, said method comprising contacting said cell with a SK channel-modulating amount of a compound of the formula: in which A, D and E are independently selected from substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl ring systems; X 1 and X 2 independently represent NR 1 , S, O, NHC(R 2 ), SC(R 3 ), OC(R 4 ), and C(R 5 ); and R 1 , R 2 , R 3 , R 4 , and R 5 are members independently selected from the group consisting of H and substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl.