Patent ID: 7579467

Claim:
A process for the preparation of compounds of formula I wherein the radicals R 1 , R 2 , R 4 and R 5 are independently hydrogen, cyano; lower alkyl; hydroxy- or amino-substituted lower alkyl; trifluoromethyl; free, etherified or esterified hydroxy; lower alkoxy; lower alkanoyloxy; free, alkylated or acylated amino; mono- or di-lower alkylamino; lower alkanoylamino; benzoylamino; free or esterified carboxy; lower alkoxycarbonyl and halogen; or R 1 and R 2 or R 4 and R 5 together are a substituted or unsubstituted alkylene radical having 4 carbon atoms, the substituents being selected from cyano, unsubstituted or hydroxy-, amino- or 4-methyl-piperazinyl-substituted lower alkyl, trifluoromethyl, free, etherified or esterified hydroxy, free, alkylated or acylated amino and free or esterified carboxy; and the other three radicals are independently hydrogen, cyano; lower alkyl; hydroxy- or amino-substituted lower alkyl; trifluoromethyl; free, etherified or esterified hydroxy; lower alkoxy; lower alkanoyloxy; free, alkylated or acylated amino; mono- or di-lower alkylamino; lower alkanoylamino; benzoylamino; free or esterified carboxy; lower alkoxycarbonyl and halogen; and R 3 is (4-methyl-piperazinyl)-methyl; R 6 is halogen, NH 2 , NO 2 , NHC(O)CF 3 , NHC(O)CH 3 , or NHC(NH)NH 2 , R 7 is methyl and R 8 is hydrogen, or a salt or crystal form thereof, wherein a compound of formula V is reacted with a compound of formula R 14 —H, wherein, R 13 is methyl substituted by a halogen, and R 14 is N-methylpiperazine or a salt thereof.