Patent ID: 7504427

Claim:
A pharmaceutical composition comprising a compound having the formula (I): wherein: Y is —C(O)—, —CH 2 , —CH 2 C(O)—, —C(O)CH 2 —, or SO 2 ; Z is —H, —C(O)R 3 , —(C 0-1 -alkyl)—SO 2 —(C 1-4 -alkyl), —C 1-8 -alkyl, —CH 2 OH, CH 2 (O)(C 1-8 -alkyl) or —CN; R 1 and R 2 are each independently —CHF 2 , —C 1-8 -alkyl, —C 3-18 -cycloalkyl, or —(C 1-10 -alkyl)(C 3-18 -cycloalkyl), and at least one of R 1 and R 2 is CHF 2 ; R 3 is —NR 4 R 5 , -alkyl, —OH, —O-alkyl, phenyl, benzyl, substituted phenyl, or substituted benzyl; R 4 and R 5 are each independently —H, —C 1-8 -alkyl, —OH, —OC(O)R 6 ; R 6 is —C 1-8 -alkyl, -amino(C 1-8 -alkyl), -phenyl, -benzyl, or -aryl; X 1 , X 2 , X 3 , and X 4 are each independent —H, -halogen, -nitro, —NH 2 , —CF 3 , —C 1-6 -alkyl, —(C 0-4 -alkyl)-(C 3-6 -cycloalkyl), (C 0-4 -alkyl)-NR 7 R 8 , (C 0-4 -alkyl)-N(H)C(O)—(R 8 ), (C 0-4 -alkyl)-N(H)C(O)N(R 7 R 8 ), (C 0-4 -alkyl)-N(H)C(O)O(R 7 R 8 ), (C 0-4 -alkyl)-OR 8 , (C 0-4 -alkyl)-imidazolyl, (C 0-4 -alkyl)-pyrrolyl, (C 0-4 -alkyl)-oxadiazolyl, or (C 0-4 -alkyl)-triazolyl triazolyl or X 1 and X 2 or X 2 and X 3 or X 3 and X 4 are taken together with the atoms that join them to form a cycloalkyl or heterocycloalkyl ring of 3, 4, 5, 6 or 7 atoms; and R 7 and R 8 are each independently H, C 1-9 -alkyl, C 3-6 -cycloalkyl, (C 1-6 -alkyl)-(C 3-6 -cycloalkyl), (C 1-6 -alkyl)-N(R 7 R 8 ), (C 1-6 -alkyl)-OR 8 , phenyl, benzyl, or aryl; or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, or prodrug thereof.