Patent ID: 7557119

Claim:
A compound of formula: wherein is an aryl or heteroaryl residue of one to three rings; A is (CH 2 ) n , wherein one or more CH 2 may be replaced by —O—, cycloalkyl or —CR 1a R 1b ; R 1a and R 1b are chosen independently from hydrogen, halogen, lower alkyl, lower alkoxy and lower alkylthio; R 2 and R 2a are both hydrogen or taken together R 2 and R 2a are ═O; R 3 is chosen from hydrogen, C 1 -C 8 hydrocarbon, heterocyclyl, heterocyclylalkyl and hydroxyalkyl; R 4 is chosen from hydrogen, hydroxy, amino, lower alkoxy, C 1 -C 20 alkyl and C 1 -C 20 alkyl substituted with hydroxy or carbonyl; R 5 is lower alkyl; R 6 is lower alkyl; R 7 is chosen from hydrogen and hydroxy; or together R 4 , R 5 , R 6 and R 7 may form from one to three rings, said rings having optional additional substitution; R 10 is one or two residues chosen independently from hydrogen, hydroxyl, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl and halo(C 1 -C 6 )alkoxy and (C 1 -C 6 )alkylthio; R 11 is H or is an aryl or heteroaryl residue of one to three rings; A′ is (CH 2 ) m , wherein one or more CH 2 may be replaced by —O—, cycloalkyl, —CR 1a R 1b , —C(═O)— or —NH—; R 12 is chosen from hydrogen and lower alkyl; R 15 is one or two residues chosen independently from hydrogen, hydroxyl, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl and halo(C 1 -C 6 )alkoxy and (C 1 -C 6 )alkylthio; m is zero or an integer from 1 to 6; and n is an integer from 1 to 6; with the proviso that A is other than CH 2 .