Patent ID: 8722855

Claim:
A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker; X2 is an Fc region; n is 0 or 1, wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding TNF and sclerostin (SOST), wherein (1) the variable domains that form a functional target binding site for TNF comprise SEQ ID NO: 38 and/or SEQ ID NO: 39, SEQ ID NO: 40 and/or SEQ ID NO: 41, SEQ ID NO: 42 and/or SEQ ID NO: 43, SEQ ID NO: 46 and/or SEQ ID NO: 47, or SEQ ID NO: 48 and/or SEQ ID NO: 49 and (2) the variable domains that form a functional target binding site for SOST comprise SEQ ID NO: 34 and/or SEQ ID NO: 35.