Patent ID: 6969710

Claim:
A compound of the formula (I) or a pharmaceutically acceptable salt thereof, wherein X is R 1 and R 3 are independently (a) H (b) C 1-6 alkyl, (c) C 1-6 alkoxy, (d) straight or branched C 1-6 hydroxyalkyl, (e) straight or branched C 1-6 alkylhalides; or (f) a group Ar; Ar is (a) phenyl, (b) 1-naphthyl, (c) 2-naphthyl, (d) benzyl, (e) cinnamoyl, (f) a 5 to 7-membered, partially or completely saturated, heterocyclic ring containing 1 to 4 heteroatoms, selected from oxygen, nitrogen and sulfur, or (g) a bicyclic ring system consisting of two heterocyclic rings as defined under (f), or a bicyclic ring system consisting of one benzene ring and one heterocyclic ring as defined under (f); alternatively, R 1 and R 3 are linked to form a group (CH 2 ) 2 O, (CH 2 ) 4 O, or (CH 2 ) 3-5 in formula (Ib); optionally, the group Ar is substituted with (a) Y, or (b) a 5 to 7-membered, partially or completely saturated, heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulfur; Y is (a) H, (b) halogen, (c) C 1-6 alkyl, (d) CF 3 , (e) hydroxy, (f) C 1-6 alkoxy, (g) C 1-4 alkenyl; (h) phenyl; (i) phenoxy, (j) benzyloxy, (k) benzoyl, (l) OCF 3 , (m) CN, (n) straight or branched C 1-6 hydroxyalkyl, (o) straight or branched C 1-6 alkylhalides, (p) NH 2 , (q) NHR 6 , (r) NR 6 R 7 , (s) NO 2 , (t) â€”CONR 6 R 7 , (u) NHSO 2 R 6 , (v) NR 6 COR 7 , (x) SO 2 NR 6 R 7 , (z) â€”C(â•O)R 6 , (aa) â€”CO 2 R 6 , or (ab) S(O) n R 6 ; wherein n is 0, 1, 2 or 3; R 2 and R 4 are independently: (a) â€”SO 2 R 1 , (b) H, (c) C 1-6 alkyl, (d) C 1 -C 3 alkenyl, (e) C 1 -C 3 alkylaryl, (f) Ar as defined above for R 1 , (g) â€”C(â•O)R 6 , (h) â€”C(O)NR 6 R 7 , (i) â€”C(S)NR 6 R 7 , (j) â€”CO 2 R 6 ; (k) â€”C(S)R 6 ; (l) straight or branched C 1-6 hydroxyalkyl, or (m) straight or branched C 1-6 alkylhalides; alternatively, R 2 and R 4 are linked to form a group (CH 2 ) 2 O, (CH 2 ) 4 O, or (CH 2 ) 3-5 in formula (Ia); R 5 is selected from the group consisting of the following chemical groups: R 6 and R 7 are independently (a) H, (b) C 1-6 alkyl, (c) C 3-7 cycloalkyl, or (d) Ar, as defined above for R 1 ; alternatively, R 6 and R 7 are linked to form a group (CH 2 ) 2 O, (CH 2 ) 4 O or (CH 2 ) 3-5 ; R 8 is (a) H, or (b) C 1-6 alkyl.