Patent ID: 8735567

Claim:
A composition comprising at least three siRNA molecules and a pharmaceutically acceptable carrier, wherein each siRNA molecule binds an mRNA molecule that is encoded by a gene selected from the group consisting of TGF-β1, Cox-2, and Hoxb13, wherein said molecules inhibit expression of said genes in both human and mouse cells, wherein said composition comprises a nanoparticle, and wherein said siRNA molecules comprise the following oligonucleotides: (1) hmTF-2: sense, 5′-CCCAAGGGCUACCAUGCCAACUUCU-3′ (SEQ ID NO: 11) antisense, 5′AGAAGUUGGCAUGGUAGCCCUUGGG-3′; (SEQ ID NO: 12) (2) hmCX-1: sense, 5′-GGUCUGGUGCCUGGUCUGAUGAUGU-3′, (SEQ ID NO: 9) antisense, 5′-ACAUCAUCAGACCAGGCACCAGACC-3′; (SEQ ID NO: 10) and (3) hmHX-1: sense, 5′-GGUGGCUGGAACAGCCAGAUGUGUU-3′ (SEQ ID NO: 7) antisense, 5′-AACACAUCUGGCUGUUCCAGCCACC-3′ (SEQ ID NO: 8).