Patent ID: 8034931

Claim:
A process for producing a substituted aminoquinazolinone represented by formula (I): (wherein R, R 1 , R 2 , X and n are as defined below), which comprises reducing a substituted iminoquinazolinone represented by formula (II): (wherein R is a hydrogen atom; a formyl group; a (C 1 -C 6 )alkyl group; a (C 1 -C 6 )alkoxy(C 1 -C 3 )alkyl group; a (C 1 -C 6 )alkylsulfonyl group; a cyano(C 1 -C 3 )alkyl group; a (C 1 -C 6 )alkylcarbonyl group; a (C 1 -C 6 )alkoxycarbonyl group; a (C 1 -C 3 )alkoxy(C 1 -C 6 )alkylcarbonyl group; a (C 3 -C 6 )cycloalkylcarbonyl group; a phenylcarbonyl group; a substituted phenylcarbonyl group having 1 to 5 substituents which may be the same or different and are selected from the group consisting of a halogen atom, a nitro group, a cyano group, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkylthio group, a halo(C 1 -C 6 )alkylthio group and a phenyl group; a phenylsulfonyl group; a substituted phenylsulfonyl group having 1 to 5 substituents which may be the same or different and are selected from the group consisting of a halogen atom, a nitro group, a cyano group, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkylthio group and a halo(C 1 -C 6 )alkylthio group; or a naphthylcarbonyl group, R 1 is a 5- or 6-membered heterocyclic group having 1 to 3 heteroatoms which may be the same or different and are selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, said heterocyclic group being able to have 1 to 5 substituents which may be the same or different and are selected from the group consisting of a halogen atom, a cyano group, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group and a (C 1 -C 6 )alkoxy groups, and a nitrogen atom in the heterocyclic group being able to represent an N-oxide group, R 2 is a hydrogen atom or a (C 1 -C 3 )alkyl group, each of Xs, which may be the same or different, is a halogen atom, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group or a pentafluorosulfanyl group, and n is an integer of 0 to 4) with hydrogen in the presence of a catalyst and an additive, wherein the catalyst is a palladium-based catalyst; the additive is iodine, iodobenzene, 2-iodoacetamide, N-iodosuccinimide, 5,5-dimethyl-1,3-diiodohydantoin, palladium iodide, 1-iodo-2-methylpropane, lithium iodide, sodium iodide, potassium iodide, dimethyl sulfoxide or diphenyl sulfoxide.