Patent ID: 7297705

Claim:
A method for the treatment of a disorder of the central nervous system wherein said disorder is schizophrenia or depression in a patient in need thereof which comprises providing to said patient a therapeutically effective amount of a compound of formula I wherein W is SO 2 , CO, CONR 11 or CSNR 12 ; X is N or CR 1 ; Y is N or CR 2 ; Z is N or CR 3 ; Q is N or CR 4 with the proviso that only one of X, Y, Z and Q may be N; n is an integer of 2 or 3; R 1 , R 2 , R 3 and R 4 are each independently H, halogen, CN, OCO 2 R 13 , CO 2 R 14 , CONR 15 R 16 , CNR 17 NR 18 R 19 , SO m R 20 , NR 21 R 22 , OR 23 , COR 24 or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 5 and R 6 are each independently H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted, or R 5 and R 6 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing an additional heteroatom selected from O, N or S; R 7 and R 8 are each independently H or an optionally substituted C 1 -C 6 alkyl group; R 9 is H, halogen, or a C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl or heteroaryl group each optionally substituted; R 10 is an optionally substituted C 1 -C 6 alkyl, aryl, or heteroaryl group or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S with the proviso that when Q is N and X, Y and Z are CH then R 10 must be other than phenyl; m is 0 or an integer of 1 or 2; R 11 and R 12 are each independently H or a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted; R 13 , R 14 , R 20 , R 23 and R 24 are each independently H or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; R 15 , R 16 are each independently H or an optionally substituted C 1 -C 6 alkyl group; and R 17 , R 18 , R 19 , R 21 , and R 22 are each independently H or an optionally substituted C 1 -C 4 alkyl group; or R 2 , and R 22 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, N or S; or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.