Patent ID: 8173710

Claim:
A compound of formula I: wherein X 1 , Y 1 and Z 1 are independently CR a and CR a R b ; R 1 is hydrogen, halo, (C 1 -C 10 )alkyl, (C 1 -C 10 )haloalkyl, or (C 1 -C 10 )alkoxy; R 2 is hydrogen, halo, (C 1 -C 20 )alkyl, (C 1 -C 20 )alkoxy; (C 2 -C 26 )alkoxyalkyl; (C 2 -C 20 )alkenyl, (C 2 -C 20 )alkynyl, (C 3 -C 12 )cycloalkyl, (C 6 -C 10 )aryl, (C 7 -C 30 )arylalkyl, (C 2 -C 10 )heterocyclic, and (C 5 -C 10 )heteroaryl; represents one optional double bond; R 3 is hydrogen, (C 1 -C 10 )alkyl, hydroxy(C 1 -C 10 )alkyl, or (C 1 -C 10 )alkoxy; R 4 is hydroxyl (—OH), phosphate (—OPO 3 H 2 ), phosphonate (—CH 2 PO 3 H 2 ), halophosphonate, or thiophosphonate; R a , and R b are independently hydrogen, or (C 1 -C 10 )alkyl; wherein the alkyl groups of R 1 are optionally substituted with 1, 2, 3, or 4 substituent groups where the substituent groups independently are halo, (C 1 -C 10 )alkoxy or cyano; wherein any of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, or heteroaryl groups of R 2 are optionally substituted with 1, 2, 3, or 4 substituent groups where the substituent groups independently are (C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy, or C 6 -aryl; or wherein one or more of the carbon atoms in the R 2 alkyl groups can be independently replaced with non-peroxide oxygen; or a pharmaceutically acceptable salt or ester thereof.