Patent ID: 7074817

Claim:
A compound of formula (I): wherein: X is â€”C(O)â€”; R 1 is selected from C 1 -C 8 alkyl, (â€”CH 2 ) n -C 3 -C 6 cycloalkyl, wherein n is an integer of from 0 to 3, pyridinyl, â€”CH 2 -pyridinyl, phenyl or benzyl, the rings of the cycloalkyl, pyridinyl, phenyl and benzyl groups being optionally substituted by, from 1 to 3 groups selected from, halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, â€”Oâ€”C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, â€”OH, â€”NH 2 , or â€”NO 2 ; R 2 is selected from H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, â€”CH 2 â€”C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl, preferably â€”CF 3 , â€”CH 2 OH or CH 2 OAc; R 3 is selected from H, halogen, C 1 -C 6 alkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 6 alkoxy, C 3 -C 6 cycloalkyl, â€”CH 2 â€”C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl, â€”CH 2 â€”C 3 -C 6 cycloalkenyl, â€”NH 2 , or â€”NO 2 ; R 4 is phenyl, substituted by from 1 to 3 groups selected from halogen, C 1 -C 4 alkyl, C 1 -C 3 perfluoroalkyl, â€”Oâ€”C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, â€”OH, â€”NH 2 , â€”NO 2 or (CO)C 1 -C 6 alkyl, or a pharmaceutically acceptable salt or ester form thereof.