Patent ID: 7737139

Claim:
A compound of formula (I): and pharmaceutically acceptable salts thereof, wherein Ar is a substituted phenyl group, selected from 3′-benzoylphenyl, 3′-(4-chloro-benzoyl)-phenyl, 3′-(4-methyl-benzoyl)-phenyl, 3′-acetyl-phenyl, 3′-propionyl-phenyl, 3′-isobutanoyl-phenyl, 4′-trifluoromethanesulfonyloxy-phenyl, 4′-benzenesulfonyloxy-phenyl, 4′-trifluoromethanesulfonylamino-phenyl, 4′-benzenesulfonylamino-phenyl, 4′-benzenesulfonylmethyl-phenyl, 4′-acetoxyphenyl, 4′-propionyloxy-phenyl, 4′-benzoyloxy-phenyl, 4′acetylamino-phenyl, 4′propionylamino-phenyl, 4′-benzoylamino-phenyl, or Ar is a substituted 5-6 membered heteroaryl ring; X represents either a —CH 2 — or a —CH(CH 3 )— group or an ethylenic group of formula (II) in the E configuration wherein R′ is hydrogen (H) or CH 3 ; Y is selected from oxygen (O) and NH; and when Y is O, R is H; when Y is NH, R is selected from H, C 1 -C 5 -alkyl, C 1 -C 5 -cycloalkyl, C 1 -C 5 -alkenyl, C 1 -C 5 -acyl, a residue of formula —CH 2 —CH 2 —Z—(CH 2 —CH 2 O)nR″ wherein R″ is H or C 1 -C 5 -alkyl, n is an integer from 0 to 2 and Z is oxygen or sulfur, a residue of formula —(CH2)n-NRaRb wherein n is an integer from 0 to 5 and each Ra and Rb, which may be the same or different, are C 1 -C 6 -alkyl, C 1 -C 6 -alkenyl or Ra and Rb, together with the nitrogen atom to which they are bound, form a heterocycle from 3 to 7 members of formula (III) wherein W represents a single bond, CH2, O, S or N-Rc, Rc being H, C 1 -C 6 -alkyl or C 1 -C 6 -alkylphenyl.