Patent ID: 8921382

Claim:
A compound of Formula (I-A): wherein: R is H, lower alkyl, phenyl, pyridine N-oxide, or a heterocycle comprising a 5 or 6 membered single ring, wherein the lower alkyl, phenyl, pyridine N-oxide, or 5 or 6 membered single ring heterocycle are optionally substituted with halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO 2 , CN, lower alkoxycarbonyl, lower alkanoyl, lower alkyl-SO q , and aldoximes and lower alkyloximes optionally substituted on oxygen by lower alkyl; Z is a single bond between the phenyl ring and a carbon atom of R, CH 2 , NH, O, S, CH 2 O, OCH 2 , CH 2 CH 2 , or OCH 2 CH 2 ; m is 4; p is 0 or 1; q is an integer from 0 to 2; R 1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO 2 , CN, lower alkanoyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes optionally substituted on oxygen by lower alkyl; Y is a single bond, C((R 5 ) n )O or C((R 5 ) n ); n is 2; R 2 are independently H or lower alkyl; R 4 is H, halogen, lower alkyl, lower alkoxy or lower haloalkyl; R 5 are independently H or lower alkyl; and X is NR 3 , or O, where R 3 is selected from H, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SO q , phenyl-SO q or substituted phenyl-SO q .