Patent ID: 7834025

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0 or 1 and when n is 0 than a direct bond is intended; m is 0, 1 or 2 and when n is 0 than a direct bond is intended; p is 0 or 1 and when n is 0 than a direct bond is intended; each X is independently N or CH; each Y is independently O, NH, N—C 1-6 alkyl, CH or CH 2 and when Y is CH then the substituent is attached to the Y atom of the ring structure; R 1 is hydroxy or a radical of formula (a-1) wherein R 9 is hydroxy or —NH 2 ; R 10 is hydrogen, thienyl, furanyl or phenyl and each thienyl, furanyl or phenyl can optionally be substituted with halo, amino, nitro, cyano, hydroxy, phenyl, C 1-6 alkyl, (diC 1-6 alkyl)amino, C 1-6 alkyloxy, phenylC 1-6 alkyloxy, hydroxyC 1-6 alkyl, C 1-6 alkyloxycarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonyl, polyhaloC 1-6 alkyloxy, polyhaloC 1-6 alkyl, C 1-6 alkylsulfonyl, hydroxycarbonylC 1-6 alkyl, C 1-6 alkylcarbonylamino, aminosulfonyl, aminosulfonylC 1-6 alkyl, isoxazolyl, aminocarbonyl, phenylC 2-6 alkenyl, phenylC 3-6 alkynyl or pyridinylC 3-6 alkynyl; R 6 , R 7 and R 8 are each independently hydrogen, —NH 2 , nitro, furanyl, halo, C 1-6 alkyl, C 1-6 alkyloxy, trifluoromethyl, thienyl, phenyl, C 1-6 alkylcarbonylamino, aminocarbonylC 1-6 alkyl or —C≡C—CH 2 —R 11 ; wherein R 11 is hydrogen, C 1-6 alkyl, hydroxy, amino or C 1-6 alkyloxy; R 2 is C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkylaminocarbonyl or C 1-6 alkyloxycarbonyl; R 3 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, hydroxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxycarbonyl or C 1-6 alkylaminocarbonyl; or R 2 and R 3 can be bridged (i.e. forming a cyclic ring system) with a methylene, ethylene or propylene bridge; R 4 is hydrogen, C 1-6 alkyl, —C(═O)—CHR 12 R 13 or —S(═O) 2 —N(CH 3 ) 2 ; wherein each R 12 and R 13 is independently hydrogen, amino, C 1-6 alkyl or aminoC 1-6 alkyl; and R 5 is hydrogen, hydroxy, amino, halo, C 1-6 alkyl, polyhaloC 1-6 alkyl, C 1-6 alkyloxycarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkyloxy, or mono- or di(C 1-6 alkyl)amino.