Patent ID: 8795630

Claim:
A compound of Formula I and pharmaceutically acceptable salts, stereo-isomers, polymorphs, metabolites, pro-drugs and combinations thereof: wherein R 1 is selected from the group consisting of hydrogen, fluoro, iodo, alkyl, and aryl; R 2 is selected from the group consisting of hydrogen, alkyl, and aryl; X is selected from the group consisting of CH 2 , CH 2 O, oxygen, OCH 2 , CH 2 S, SCH 2 , NH, N-alkyl, and N-aryl; Y is an optional spacer group, absent or selected from the group consisting of oxygen, sulfur, NH, N-alkyl, and N-aryl; and Z is selected from the group consisting of alkyl substituted with cyano, fluoro, or iodo and aryl substituted with cyano, fluoro, or iodo; with the exception that if Y is absent or NH, then X cannot be NH.