Patent ID: 7572786

Claim:
A compound according to the general Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof or prodrug thereof, wherein: n is 1; m is 1; p is 1 or 2; q is 0; Q is O; X is a covalent bond; each R 1 independently from each other, is Ar 1 or Ar 1 -alkyl; R 2 is Ar 2 , Ar 2 -alkyl, or di(Ar 2 )alkyl; Y is a covalent bond or a bivalent radical of formula —C(═O)—, —SO 2 —, >C═CH—R or >C═N—R, wherein R is CN or nitro; each Alk represents, independently from each other, a covalent bond; a bivalent straight or branched, saturated or unsaturated hydrocarbon radical having from 1 to 6 carbon atoms; or a cyclic saturated or unsaturated hydrocarbon radical having from 3 to 6 carbon atoms; each radical optionally substituted on one or more carbon atoms with one or more phenyl, halo, cyano, hydroxy, formyl or amino radicals; L is hydrogen, alkyl, alkyloxy, Ar 3 -oxy, alkyloxycarbonyl, alkylcarbonyloxy, mono- or di(alkyl)amino, mono- or di(Ar 3 )amino, Ar 3 , Ar 3 carbonyl, Het 2 or Het 2 carbonyl; Ar 1 is phenyl, optionally substituted with 1, 2 or 3 substituents, each independently from each other, selected from the group consisting of halo, alkyl, cyano, aminocarbonyl and alkyloxy; Ar 2 is naphthalenyl or phenyl, each optionally substituted with 1, 2 or 3 substituents, each independently from each other, selected from the group consisting of halo, nitro, amino, mono- and di(alkyl)amino, cyano, alkyl, hydroxy, alkyloxy, carboxyl, alkyloxycarbonyl, aminocarbonyl and mono- and di(alkyl)aminocarbonyl; Ar 3 is naphthalenyl or phenyl, optionally substituted with 1, 2 or 3 substituents, each independently from each other, selected from the group consisting of alkyloxy, alkyl, halo, hydroxy, Ar 1 carbonyloxycarbonyl, pyridinyl, morpholinyl, pyrrolidinyl, imidazo[1,2-a ]pyridinyl, morpholinylcarbonyl, pyrrolidinylcarbonyl, amino, and cyano; Het 2 is a heterocyclic radical that is tetrahydrofuranyl, pyrrolidinyl, imidazolyl, pyrazolyl, furanyl, thienyl, isoxazolyl, thiazolyl, thiadiazolyl, pyridinyl, pyrazinyl, benzo[2,1,3]oxadiazolyl, or imidazo-[2,1-b]thiazolyl; each radical may optionally be substituted with one or more radicals selected from the group consisting of Ar 1 , Ar 1 alkyl, Ar 1 alkyloxyalkyl, halo, hydroxy, alkyl, alkylcarbonyl, alkyloxy, alkyloxyalkyl, alkyloxycarbonyl, piperidinyl, pyridinyl, pyrrolyl, thienyl, oxo and oxazolyl; and alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms; optionally substituted on one or more carbon atoms with one or more radicals selected from the group consisting of phenyl, halo, cyano, oxo, hydroxy, formyl and amino.