Patent ID: 7078429

Claim:
Compounds of formula (I): wherein: R 1 is hydrogen, C 2 –C 6 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, or C 1 –C 3 perfluoroalkyl, wherein the alkyl and cycloalkyl groups may be optionally substituted with halogen, —CN, C 1 –C 6 alkoxy, —OH, —NH 2 , or —NO 2 ; R 2 is hydrogen, or C 1 –C 8 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, oxazoyl, CH 2 -oxazoyl, phenyl, benzyl, CH 2 -naphthyl, wherein the alkyl group and the rings of the cycloalkyl, oxazoyl, phenyl, benzyl, and napthyl groups may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 –C 3 alkyl, C 1 –C 3 perfluoroalkyl, —O—C 1 –C 3 perfluoroalkyl, —S—C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 6 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 3 is hydrogen, halogen, C 1 –C 6 alkyl, C 1 –C 3 perfluoroalkyl, C 1 –C 6 alkoxy, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, —NH 2 , or —NO 2 ; R 4 is C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, oxazoyl, phenyl, benzo[1,3]dioxol-5-yl, naphthyl, wherein the alkyl groups and the rings of the cycloalkyl, oxazoyl, phenyl, and naphthyl groups may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 –C 3 alkyl, C 1 –C 3 perfluoroalkyl, —O—C 1 –C 3 perfluoroalkyl, —S—C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, —OCHF 2 , —CN, —COOH, CH 2 CO 2 H, —C(O)CH 3 , —C(O)OR 6 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 5 is C 1 –C 8 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, oxazoyl, CH 2 -oxazoyl, phenyl, benzyl, benzo[1,3]dioxol-5-yl, naphthyl, CH 2 -naphyl, 9H-fluoren-1-yl, 9H-fluoren-4-yl, 9H-fluoren-9-yl, 9-fluorenone-1-yl, 9-fluorenone-2-yl, 9-fluorenone-4-yl, CH 2 -9H-fluoren-9-yl, wherein the alkyl group and the rings of the cycloalkyl, oxazoyl, phenyl, benzyl, napthyl, fluorenyl, and fluorenone groups may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 –C 3 alkyl, C 3 –C 6 cycloalkyl, C 1 –C 3 perfluoroalkyl, —O—C 1 –C 3 perfluoroalkyl, —S—C 1 –C 3 perfluoroalkyl, C 1 –C 3 alkoxy, phenoxy, —OCHF 2 , —CN, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 6 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 , wherein the phenoxy group may be optionally substituted by from 1 to 3 groups selected from halogen, C 1 –C 3 alkyl, or C 1 –C 3 perfluoroalkyl; and R 6 is C 1 –C 6 alkyl, C 3 –C 6 cycloalkyl, —CH 2 —C 3 –C 6 cycloalkyl, or benzyl; or a pharmaceutically acceptable salt or ester form thereof.