Patent ID: 7101556

Claim:
A fusion protein comprising: an amino acid sequence of Plasmodium apical membrane antigen-1 (AMA-1), an amino acid sequence of Plasmodium merozoite surface protein 1 (MSP1), and a hinge between the amino acid sequence of the apical membrane antigen-1 and the amino acid sequence of the merozoite surface protein 1, wherein the amino acid sequence of AMA-1 is selected from the group consisting of the amino acid sequence of natural full-length AMA-1, the amino acid sequence of the whole ectodomain of AMA-1, the amino acid sequence of domain III of AMA-1, and the amino acid sequence of domain I-III of AMA-1; and the amino acid sequence of MSP1 is selected from the group consisting of the amino acid sequence of natural full-length MSP1 and the amino acid sequence of MSP1 19KD C-terminal; the hinge comprising an amino acid sequence selected from the group consisting of: (a) an amino acid sequence containing 6 amino acids comprising hydrophobic amino acids Gly and Pro; (b) an amino acid sequence encoded by multiple cloning sites; and (c) a combination of (a) and (b).