Patent ID: 7205278

Claim:
A mutant Factor VIII which comprises at least one pair of cysteines introduced, wherein the pair of cysteines replaces a pair of residues selected from the group consisting of Met 662 and Asp 1828, Ser 268 and Phe 673, Ile 312 and Pro 672, Ser 313 and Ala 644, Met 662 and Lys 1827, Tyr 664 and Thr 1826, Pro 264 and Gln 645, Arg 282 and Thr 522, Ser 285 and Phe 673, His 311 and Phe 673, Ser 314 and Ala 644, Ser 314 and Gln 645, Val 663 and Glu 1829, Asn 694 and Pro 1980, and Ser 695 and Glu 1844.