Patent ID: 7273608

Claim:
A humanized antibody comprising; a) a light chain variable region comprising the amino acid sequence of SEQ ID NO:1 wherein the L4, L24-L34, L50-L56, L66-L69, and L89-L97 residues of trastuzumab variable light chain (residues 4, 24-34, 50-56, 66-69, and 89-97, respectively, of SEQ ID NO:6) have been replaced with the corresponding residues from murine T84.66 monoclonal antibody variable light chain (residues 4, 24-38, 54-60, 70-73, and 93-101, respectively, of SEQ ID NO:4); and b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:2 wherein the H30-H35, H50-H58, and H93-H102 residues of trastuzumab variable heavy chain (residues 30-35, 50-59, and 97-109, respectively, of SEQ ID NO:7) have been replaced with the corresponding residues from the murine T84.66 monoclonal antibody variable heavy chain (residues 30-35, 50-59, and 97-110, respectively of SEQ ID NO:5)