Patent ID: 7470677

Claim:
A method of protecting cells from oxidant-induced toxicity comprising contacting said cells with a non-toxic amount of a scavenger of the formula, or a pharmaceutically acceptable salt thereof, or metal complex thereof, sufficient to effect said protection; wherein: said metal is selected from the group consisting of manganese, copper and iron, each R 1 ′ is independently a bond, wherein Y″ is an alkyl group, and indicates bonding to R 2 ′ at any position and indicates bonding to R 2 ′ and the R 1 ′ phenyl substituent at any position; each R 2 ′ is independently a bond, or —(CH 2 ) n — wherein n is 1–4, each R 3 ′ is independently —Y″, —Y′″, —H, —OH, —OY″, —NO 2 , —CN, —NH 2 , —COOH, —COY″, —COO − , substituted or unsubstituted tetrazole, substituted or unsubstituted furan, substituted or unsubstituted thiophene, substituted or unsubstituted indole, substituted or unsubstituted imidazole, substituted or unsubstituted oxadiazole, or substituted or unsubstituted quinoline, wherein Y″ is as defined above and Y′″ is a primary, secondary, or tertiary amine, with the proviso that when R 1 ′ is R 3 ′ is not —COOH, —COY″ or —COO − , when R 1 ′ R 3 ′ is not —NO 2 , —R 1 ′—R 2 ′—R 3 ′ collectively are not —H, and when R 1 ′ is a substituted phenyl and R 2 ′ is —(CH 2 ) n —, n is not 1 or R 3 ′ is not Y′″.