Patent ID: 7062312

Claim:
A method of monitoring the compliance of a patient in following a medication regimen, said method comprising the steps of: providing in combination an orally administrable composition, which is part of a medication regimen, and multiple markers present in said combination, one of said markers causing a contact coloration of at least a portion of a mucous membrane or buccal membrane of the oral and/or pharyngeal cavity of a patient following oral ingestion of said combination by said patient for a longer time than another of said markers, the half-life of at least one marker being comparable to the half-life of said composition; visually observing the oral and/or pharyngeal cavity of said patient; determining the presence or absence of said contact coloration for determining whether said patient has ingested said combination in compliance with the medication regimen; and determining the presence or absence of contact coloration caused by the multiple markers to determine a time frame in which the combination was ingested.