Patent ID: 7285563

Claim:
A compound of formula (I): wherein A and E are each carbon; one of B and D is carbon, and one of B and D is nitrogen; R 1 and R 2 are each independently hydrogen, halogen, hydroxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, hydroxyC 1-6 alkoxy, C 3-7 cycloalkyl, C 3-5 cycloalkylC 1-4 alkyl, NR 7 R 8 , carboxy, esterified carboxy, C 1-6 alkyl substituted with a group selected from NR 7 R 8 , carboxy and esterified carboxy, or C 1-6 alkoxy substituted with a group selected from NR 7 R 8 , carboxy and esterified carboxy; R 3 and R 4 are each independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; R 5 and R 6 are, at each occurrence, independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 acyloxy, carboxy, esterified carboxy, CONR 7 R 8 , SO 2 R 7 , SO 2 NR 7 R 8 , aryl, heteroaryl, heterocyclyl, or C 1-6 alkyl substituted with a group selected from hydroxy, C 1-6 alkoxy, C 1-6 acyloxy, carboxy, esterified carboxy, NR 7 R 8 , CONR 7 R 8 , SR 7 , SO 2 R 7 , SO 2 NR 7 R 8 , aryl, heteroaryl and heterocyclyl; or R 5 and R 6 and the carbon atom to which they are attached together form a carbocyclic ring of 3 to 6 carbon atoms; R 7 and R 8 are, at each occurrence, independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or fluoroC 1-6 alkyl; or R 7 and R 8 and the nitrogen atom to which they are attached together form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by one or two groups selected from hydroxy or C 1-4 alkoxy, which ring may optionally contain as one of the said ring atoms an oxygen or a sulfur atom, a group S(O) or S(O) 2 , or a second nitrogen atom which will be part of a NH or NR a moiety where R a is C 1-4 alkyl optionally substituted by hydroxy or C 1-4 alkoxy; X is an oxygen; Y is an aryl group selected from unsubstituted naphthyl and phenyl or naphthyl substituted by one or two substituents selected from halogen, C 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy, phenyl, cyano, nitro, pyrazolyl, di(C 1-6 alkyl)amino, phenoxy, —OCH 2 O— and C 1-6 alkylcarbonyl; or Y is a heteroaryl group selected from pyridyl, thiazolyl, isoxazolyl, oxadiazolyl and pyrazolyl wherein each heteroaryl group is optionally substituted with one or two substituents selected from C 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy, unsubstituted heteroaryl or phenyl which may be substituted by C 1-6 alkyl or halogen; or Y is a fused-carbocyclyl group which is a C 5-7 cycloalkyl radical that is fused to a phenyl ring; n is zero; or a pharmaceutically acceptable salt, N-oxide or a prodrug thereof.