Patent ID: 7323484

Claim:
A compound having the formula wherein: R 1 is H, lower alkyl, cycloalkylthio, or lower alkylthio, or, together with R 2 , form —CH 2 — or —C(CH 3 ) 2 —; each of R 2 and R 3 , independently, is H or lower alkyl; R 4 is H 2 or O; R 5 is H, or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is lower alkyl, —O—R 10 , —S(O) m R 10 (where m is 0, 1, or 2), —N(R 10 ) (R 11 ), —N—C(O)—R 10 , —NH—(SO 2 )—R 10 ; —CO 2 —R 10 , —C(O)—N(R 10 )(R 11 ), or —(SO 2 )—N(R 10 )(R 11 ); each of R 6 and R 7 , independently, is H, —C(O)NHCHR 13 CO 2 R 14 , or substituted or unsubstituted lower alkyl, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is OH, lower alkyl, lower alkoxy, aryloxy, aryl lower alkoxy, —N(R 10 )(R 11 ), —COOH, —C(O)—N(R 10 )(R 11 ), or halo or R 6 and R 7 , together, form aryl or heterocyclyl; each of R 8 and R 9 , independently, is H, or substituted or unsubstituted lower alkyl, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is OH, lower alkyl, lower alkoxy, —N(R 10 )(R 11 ), —COOH, —C(O)—N(R 10 )(R 11 ), or halo or R 8 and R 9 , together, form aryl or heterocyclyl; and each of R 10 and R 11 , independently, is H, lower alkyl, aryl, aryl lower alkyl, cycloalkyl, cycloalkyl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl; R 12 is NR 9; R 13 is substituted or unsubstituted lower alkyl wherein the substituent is lower alkyl, —OR 10 ,—S(O) m R 10 (wherein m is 0, 1, or 2) or —N(R 10 )(R 11 ); and R 14 is H or lower alkyl; or a pharmaceutically acceptable salt thereof.