Patent ID: 8658646

Claim:
A compound of Formula I wherein: R is H; R′ is lower alkoxy or or R and R′ together form heterocycloalkyl, optionally substituted with —CN; R 1 is H or R 1a ; R 1a is lower alkyl, cycloalkyl, lower alkoxy, hydroxy lower alkyl, or lower haloalkyl; R 1′ is H or lower alkyl; or R 1a and R 1′ together form heterocycloalkyl, cycloalkyl, indan-1-yl, phenyl, or heteroaryl, optionally substituted with one or more R 1″ ; each R 1″ is independently hydroxy, amino, oxo, lower alkyl, —C(═O)NH 2 , —CN, lower haloalkyl, benzyl, cyano lower alkyl, or —NHC(═O)OC(CH 3 ) 3 ; R 2 is H, hydroxy, —CN, —C(═O)NH 2 , —C(═O)OH, —C(═O)OC(CH 3 ) 3 , R 2a , or R 2b ; R 2a is lower alkyl, phenyl, phenyl lower alkyl, cycloalkyl, heteroaryl, heterocycloalkyl, heterocycloalkyl lower alkyl, heteroaryl lower alkyl, phenyl lower alkoxy, lower alkoxy, optionally substituted with one or more R 2a′ ; each R 2a′ is independently hydroxy, —CN, amino, lower alkyl sulfonylamino, lower alkoxy, halo, lower alkyl, cyano lower alkyl, lower haloalkyl, lower alkyl sulfonyl, oxo, halo lower alkoxy, cycloalkyl, —C(═O)OCH 3 ; R 2b is —C(═O)R 3 or —CH 2 C(═O)R 3 ; R 3 is heterocycloalkyl, optionally substituted with one or more R 3′ ; each R 3′ is independently —CN, halo, lower alkyl, or lower alkyl sulfonyl; Q is a 1H-indazol-3-yl, 4,5,6,7-tetrahydro-1H-indazol-3-yl, 1H-indol-3-yl, 5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl, imidazo[1,5-a]pyridin-1-yl, indazol-1-yl, 1H-pyrazolo[3,4-b]pyridin-3-yl, 1H-pyrazolo[4,3-b]pyridin-3-yl, imidazo[1,2-a]pyridin-3-yl, 2-oxy-4,5,6,7-tetrahydro-1H-indazol-3-yl, benzoimidazol-1-yl, isoquinolin-1-yl, isoquinolin-8-yl, 1H-thieno[3,2-c]pyrazol-3-yl, 1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl, 5,6-dihydro-4H-cyclopentapyrazol-1-yl, 1,4,5,6,7,8-hexahydro-cycloheptapyrazol-3-yl, 1H-indol-7-yl, 1H-pyrrolo[2,3-c]pyridin-7-yl, 1H-indazol-4-yl or 1H-indazol-7-yl, optionally substituted with one or more Q a or Q b ; each Q a is independently halo, —CN, hydroxy, or —(CH 2 ) n C(═O)Q a′ ; each Q a′ is independently hydroxy, amino, or heterocycloalkyl, wherein heterocycloalkyl is optionally substituted by one or more Q a″ ; each Q a″ is independently lower alkyl or lower haloalkyl; n is 1, 2, or 3; each Q b is independently lower alkyl, cycloalkyl, lower alkoxy, phenoxy, lower alkyl sulfonyl, heterocycloalkyl, heterocycloalkyl lower alkyl, or heteroaryl lower alkyl, optionally substituted with one or more Q b′ ; and each Q b′ is independently hydroxy, halo, —CN, amino, heterocycloalkyl, lower alkyl, benzyl, or lower alkyl sulfonyl; or a pharmaceutically acceptable salt thereof.