Patent ID: 8044103

Claim:
A method of treating a neurodegenerative disorder in a subject comprising administering to said subject in need of such treatment an effective amount of a compound having the formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein: n is an integer from 0 to 3; X is selected from the group consisting of —S—, —O—, —NR— and CH 2 —; R 1 and R 2 are each independently selected from the group consisting of —H, —OR, —SR, —NRR, —NO 2 , CN, —C(O)OR, —C(O)NRR, —C(NR)NRR, trihalomethyl, halogen, (C 1 -C 6 ) alkyl, substituted (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, substituted (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, substituted (C 2 -C 6 ) alkynyl, (C 5 -C 20 ) aryl, substituted (C 5 -C 20 ) aryl, 5-20 membered heteroaryl, substituted 5-20 membered heteroaryl, (C 6 -C 26 ) alkaryl, substituted (C 6 -C 26 ) alkaryl, 6-26 membered alk-heteroaryl and substituted 6-26 membered alk-heteroaryl, or R 1 and R 2 taken together are —CH 2 —(CH 2 ) m —CH 2 —, where m is an integer from 0 to 6; each alkyl, alkenyl, alkynyl, aryl, alkaryl, heteroaryl or alk-heteroaryl substitutent is independently selected from the group consisting of —OR, —SR, —NRR, —CN, —NO 2 , —C(O)OR, —C(O)NRR, —C(S)NRR, —C(NR)NRR, halogen and trihalomethyl; and each R is independently selected from the group consisting of —H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 5 -C 20 ) aryl, 5-20 membered heteroaryl, (C 6 -C 26 ) alkaryl and 6-26 membered alk-heteroaryl.