Patent ID: 7598379

Claim:
A process for preparing a compound of formula VII: the process, comprising: (a) contacting a 5,6-diamino-1H-pyrimidine-2,4-dione of formula II: with an acylating agent of formula VI: in an aprotic solvent to produce a 1H-pryimidine-2,4-dione of formula IV: (b) contacting the 1H-pryimidine-2,4-dione of formula IV with a base to produce a xanthine of formula VII; wherein: X′ and X″ are each independently selected from the group consisting of Cl, Br, and I; R 1 is (C 3-8 )cycloalkyl; and, R 2 is hydrogen, or is selected from the group consisting of substituted or unsubstituted (C 1-8 )alkyl, halo(C 1-8 )alkyl-, (C 3-8 )alkenyl, (C 3-8 )alkenyl(C 1-8 )alkyl-, (C 3-8 )alkynyl, (C 3-8 )alkynyl(C 1-8 )alkyl-, (C 1-8 )alkoxy, (C 3-8 )cycloalkyl, (C 3-8 )cycloalkyl(C 1-8 )alkyl-, (C 4-10 )hererocyclyl, (C 4-10 )heterocyclyl(C 1-8 )alkyl-, (C 6-10 )aryl, (C 6-10 )aryloxy, (C 6-10 )aryl(C 1-8 )alkyl-, (C 5-10 )heteroaryl, and (C 5-10 )heteroaryl(C 1-8 )alkyl-.