Patent ID: 8138315

Claim:
An antibody derived targeting-ligand capable of monovalent binding and having specificity for alpha V integrin comprising: (a) a first polypeptide domain comprising the light chain variable region comprising residues 1-108 of SEQ ID NO: 2; (b) a second polypeptide domain comprising the heavy chain variable region comprising residues 1-119 of SEQ ID NO: 1, wherein the heavy chain variable region has a leucine substitution at the 18 th amino acid; (c) further comprising at least one peptide linker linking said first and second polypeptide domains into a single chain Fv polypeptide wherein the linker has an amino acid sequence of the formula (Gly 4 Ser) n of SEQ ID NOS: 6-9 where n is an integer of 1-4: and wherein the targeting ligand retains specificity for at least one alpha V integrin.