Patent ID: 8058264

Claim:
A method for treating type II diabetes and/or insulin resistance in a mammal or a human subject comprising: administering to a subject in need thereof an effective amount of at least one K ATP channel opener in combination with at least one CB 1 antagonist wherein the at least one K ATP channel opener is chosen from pinacidil; cromakalim; diazoxide; BPDZ 44; BPDZ 49; BPDZ 62; BPDZ 73; BPDZ 79; BPDZ 83; BPDZ 154; BPDZ 216 (=NNC 55-9216); NN414; NNC 55-0118; NNC 55-0462; MCC-134; SR 47063 and WAY 135201; and wherein the at least one CB 1 antagonist is chosen from compounds of Formula I, wherein: R and R 1 are the same or different and are chosen from naphthyl, phenyl, thienyl and pyridyl groups, wherein the phenyl, thienyl and pyridyl groups may be substituted with 1, 2 or 3 substituents Y, which can each be the same or different; R 2 is chosen from hydrogen, hydroxy, C 1-3 -alkoxy, acetyloxy and propionyloxy groups; Y is chosen from C 1-3 -alkyl, C 1-3 -alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, mono- or dialkyl (C 1-2 )-amino, mono- or dialkyl (C 1-2 )-amido, (C 1-3 )-alkyl sulfonyl, dimethylsulfamido, C 1-3 -alkoxycarbonyl, carboxyl, trifluoromethylsulfonyl, cyano, carbamoyl, sulfamoyl and acetyl groups; Aa is chosen from one of the groups (i), (ii), (iii), (iv) and (v), wherein R 4 is chosen from acetamido, dimethylamino, 2,2,2-trifluoroethyl, phenyl, and pyridyl groups; and R 5 is hydrogen; or R 4 and R 5 independently of each other are chosen from hydrogen, C 1-8 branched or unbranched alkyl, and C 3-8 cycloalkyl groups; R 6 is chosen from hydrogen and C 1-3 unbranched alkyl groups; Bb is chosen from sulfonyl and carbonyl groups; R 3 is chosen from pyrrolidinyl, piperidinyl, morpholinyl, naphthyl, benzyl, phenyl, thienyl and pyridyl groups, wherein the benzyl, phenyl, thienyl and pyridyl groups may be substituted with 1, 2 or 3 substituents Y, which can be the same or different; a prodrug thereof, a tautomer thereof or a pharmaceutically acceptable salt thereof.