Patent ID: 7452687

Claim:
A method of detecting mild impaired glucose tolerance or an insulin secretory defect in a subject, wherein the method comprises: providing urine samples from said subject, wherein the samples are obtained before and after glucose load, or before and after a meal; quantitatively determining the myo-inositol level in the samples; and determining that the subject has mild impaired glucose tolerance or that the subject has an insulin secretory defect based on the concentration of myo-inositol in the samples, wherein the increment of the concentration of myo-inositol at a characteristic value or higher than a characteristic value of 0 to 20 μg myo-inositol per mg creatinine when measured as an increasing amount of myo-inositol excreted in the urine in a period from 0.5 to 6 hours after 75 g glucose load indicates the subject has mild impaired glucose tolerance or the subject has an insulin secretory defect.