Patent ID: 6861508

Claim:
An isolated polypeptide having a TIF2 protein activity comprising an amino acid sequence selected from the group consisting of: (a) amino acids 1 to 1464 of SEQ ID NO:2; (b) the complete amino acid sequence as encoded by the cDNA contained in ATCC Deposit No. 97612, (c) amino acids 624 to 869 of SEQ ID NO:2; (d) amino acids 624 to 1131 of SEQ ID NO:2; (e) amino acids 1010 to 1131 of SEQ ID NO:2; (f) amino acids 1288 to 1464 of SEQ ID NO:2; (g) amino acids 624 to 1287 of SEQ ID NO:2; (h) amino acids 624 to 1179 of SEQ ID NO:2; (i) amino acids 624 to 1010 of SEQ ID NO:2; (j) amino acids 1180 to 1269 of SEQ ID NO:2; (k) amino acids 870 to 1179 of SEQ ID NO:2; (l) amino acids 1010 to 1179 of SEQ ID NO:2; (m) amino acids 940 to 1179 of SEQ ID NO:2; (n) amino acids 940 to 1131 of SEQ ID NO:2; and (o) an amino acid sequence at least 90% identical to any of (a)-(n); wherein said TIF-2 activity is selected from a group consisting of: binding to a nuclear receptor and enhancing transcription.