Patent ID: 8183340

Claim:
A di-PEGylated GLP-1 compound comprising amino acid sequence: Formula I (SEQ ID NO: 1) His-Xaa 8 -Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser- Tyr-Leu-Glu-Xaa 22 -Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala- Trp-Leu-Xaa 33 -Lys-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro- Pro-Pro-Cys 45 -Xaa 46 wherein Xaa 8 is Val, Xaa 22 is Glu, Xaa 33 is Ile, and Xaa 46 is Cys-NH 2 and wherein one PEG molecule is covalently attached to Cys 45 and one PEG molecule is covalently attached to Cys 46 -NH 2 and wherein each of the PEG molecules has a molecular weight of about 20,000 daltons.