Patent ID: 7074786

Claim:
A compound of general formula I, II, or a pharmaceutically acceptable salt thereof: wherein: A is -hydrogen, â€”(C 1 â€“C 8 )alkyl or â€”(C 1 â€“C 8 )alkyl substituted by hydroxy; B is â€”(C 1 â€“C 6 )alkylguanidino, â€”(C 1 â€“C 6 )alkyl(4-imidazolyl), â€”(C 1 â€“C 6 )alkylamino, p-aminophenylalkyl(C 1 â€“C 6 )â€”, p-guanidinophenylalkyl(C 1 â€“C 6 )â€” or 4-pyridinylalkyl (C 1 â€“C 6 )â€”; D is â€”(CO)â€”, â€”(CO)â€”(C 1 â€“C 6 )alkylene or â€”(C 1 â€“C 6 )alkylene; E is a single bond or â€”(C 1 â€“C 6 )alkylene; Z is â€”NH 2 , â€”NHâ€”(C 1 â€“C 6 )alkylcarboxamide, â€”NHâ€”(C 1 â€“C 6 )alkyl, â€”NHâ€”(N-benzyl), â€”NH-cyclo(C 5 â€“C 7 )alkyl, â€”NH-2-(1-piperidyl)ethyl, â€”NH-2-(1-pyrrolidyl)ethyl, â€”NH-2-(1-pyridyl)ethyl, â€”NH-2-(morpholino)ethyl, -morpholino, -piperidyl, â€”OH, â€”(C 1 â€“C 6 )alkoxy, â€”O-benzyl or â€”O-halobenzyl; R 1 , R 2 and R 3 are, independent of one another, -hydrogen, -arylcarbonylamino, â€”(C 1 â€“C 6 )alkoylamino, â€”(C 1 â€“C 6 )alkylamino, â€”(C 1 â€“C 6 )alkyloxy, â€”(C 2 â€“C 6 )alkylaminocarbonyl, -carboxy, â€”OH, -benzoyl, -p-halogenobenzoyl, -methyl, â€”S-(2,4-dinitrophenyl), â€”S-(3-nitro-2-pyridinesulfenyl), -sulfonyl, -trifluoromethyl, â€”(C 1 â€“C 6 )alkylaminocarbonylamino, -halo or -amino; R 4 and R 5 are, independent of one another, -hydrogen, â€”(C 1 â€“C 6 )alkyl, -methyloxy, -nitro, -amino, -arylcarbonylamino, â€”(C 1 â€“C 6 )alkoylamino, â€”(C 1 â€“C 6 )alkylamino, -halo or â€”OH.