Patent ID: 7524464

Claim:
A disposable, integrated biochip for clinical diagnostic applications, said biochip comprising: a. at least one micro-sensor for sensing at least one relevant parameter of said sampled fluid; b. micro-calibration system connected to said at least one micro-sensor to calibrate said biochip comprising: i. a metallic calibration solution pouch containing a calibration buffer of at least one known concentration of at least one analyte; ii. at least one micro-fluidic channel, connecting to said calibration solution pouch, to carry said calibration buffer to said at least one micro-sensor when said calibration solution pouch is ruptured; and iii. at least one waste reservoir to accept said calibration buffer after said biochip is calibrated; c. a micro-needle for sampling a fluid from a subject; and d. a passive micro-fluidic control system, connecting said micro-needle to said at least one micro-sensor, to accept said sampled fluid from said micro-needle and to facilitate movement of said sampled fluid to said at least one micro-sensor.