Patent ID: 8076486

Claim:
A compound of Formula (I), as well as tautomers- and pharmaceutically acceptable salts thereof, wherein: Y is independently selected from NR′, CR′, S or O, whereby at least one Y is NR′; R 1 is selected from hydrogen, trimethylsilyl, C 1 -C 6 -alkyl, OR 6 , C(O)OR 6 , NR 7 R 8 , SR 6 , NR 7 S(O)(O)R′, NR 7 C(O)R 6 , NR 7 C(O)NR 7 R 6 , NR 7 C(O)OR 6 , NR 7 C(O)C(O)OR 6 , C 1 -C 4 -alkyl-NR′R″, C 1 -C 4 -alkyl-heterocycloalkyl or C 1 -C 4 alkyl-(OR′) n ; R 2 is halogen; R 3 is selected from Cl, F or I; R 4 and R 5 are independently selected from hydrogen, halogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, wherein said alkyl or alkoxy is substituted or unsubstituted; R 6 , R 7 and R 8 are independently selected from hydrogen, C 1 -C 10 alkyl, C 3 -C 10 cycloalkyl, aryl, heteroaryl, heterocycloalkyl, C 1 -C 4 alkyl-C(O)OR′, C 1 -C 4 alkyl-OR′, C 1 -C 4 -alkyl-NR′R″, C 1 -C 4 -alkyl-heterocycloalkyl, C 1 -C 4 alkyl-(OR′) n or C 1 -C 4 alkyl-C(O)NR′R″, wherein said alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, and alkyl-heterocycloalkyl is substituted or unsubstituted; or R 7 and R 8 can be taken together with the atom to which they are attached to form a 4 to 10-membered heteroaryl or heterocyclic ring, each of which is substituted or unsubstituted; R′ and R″ are independently selected from hydrogen, C 1 -C 6 -alkyl or aryl, wherein said alkyl or aryl is substituted or unsubstituted; or R′ and R″ can be taken together with the atom to which they are attached to form a 4 to 10-membered heteroaryl or heterocyclic ring, each of which is substituted or unsubstituted; and n is 0 to 2.