Patent ID: 7119074

Claim:
A method of treating a mammalian subject having a disease condition selected from the group consisting of cancers, tumors, and malignancies, said method comprising administering to the subject of an effective disease treating amount of a prodrug comprising: (a) at least one therapeutic compound selected from the group consisting of a therapeutic compound comprising etoposide and a therapeutic compound comprising an etoposide analog which retains some or all of the therapeutic activity of etoposide; and (b) one or more PEG polymers and/or oligomers, each joined to a bonding site on the therapeutic compound by a hydrolyzable bond, said PEG polymers and/or oligomers each: (i) comprising a straight or branched PEG segment consisting of 1 to 25 polyethylene glycol units; and (ii) comprising a salt-forming moiety.