Patent ID: 8753828

Claim:
A method of assessing the presence of CC-chemokine receptor 2 (CCR2) in a sample through the progression of a cancer associated with CCR2 expression, comprising: contacting the sample with a humanized immunoglobulin or antigen binding portion thereof having binding specificity for CCR2 comprising a heavy chain and a light chain, wherein the heavy chain comprises the amino acid sequences of SEQ ID NO:17 and the amino acid sequence of SEQ ID NO:110 or a portion thereof, and wherein the light chain comprises the amino acid sequence of SEQ ID NO:12 and the amino acid sequence of SEQ ID NO:112, under conditions suitable for specific binding of the humanized immunoglobulin or antigen binding portion thereof to CCR2; and determining whether binding occurred between the immunoglobulin or antigen binding portion thereof, and CCR2 to form a complex, wherein a complex is indicative of the presence of CCR2 in the sample.