Patent ID: 6952650

Claim:
A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of: (a) providing a molecular model comprising one or more target regions selected from the group consisting of at least a portion of (i) a peptidyl transferase site, (ii) an A-site, (iii) a P-site, (iv) an E-site, (v) an elongation factor binding domain, (vi) a polypeptide exit tunnel, and (vii) a signal recognition particle (SRP) binding domain, from the atomic co-ordinates for Haloarcula marismortui large ribosomal subunit found on Disk 1under file name 1JJ2.RTF, 1JJ2.TXT, 1JJ2.PDB, PDB1FFK.DOC, or PDB1FFK.ENT, or deposited at the Protein Data Bank under accession number PDB ID: 1JJ2 or 1FFK, or derived from said Haloarcula marismortui atomic co-ordinates by molecular modeling; (b) using the molecular model to identify a candidate molecule that can bind to the one or more target regions in the molecular model; and (c) producing the candidate molecule identified in step (b).