Patent ID: 7141581

Claim:
A method of treating a hyperproliferative disorder in a mammal, the method comprising administering to said mammal a therapeutically effective amount of a composition comprising a compound of formula I: wherein: R 1 is a substituted or unsubstituted aryl or heteroaryl, or a group of the formula CH═CH—R 3 or CH═N—R 3 where R 3 is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and R 2 is a substituted or unsubstituted aryl, heteroaryl, or Y—X, where Y is O, S, C═CH 2 , C═O, S═O, SO 2 , alkylidene, NH, or N—(C 1 –C 8 alkyl), and X is substituted or unsubstituted Ar, heteroaryl, NH-(alkyl), NH-(cycloalkyl), NH-(heterocycloalkyl), NH(aryl), NH(heteroaryl), NH-(alkoxyl), or NH-(dialkylamide); or pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier.