Patent ID: 7348356

Claim:
A compound of the formula I: wherein: R 1 is R 2 is selected from the group consisting of: (1) R 4 —S(O) m —NR 5 —, (2) R 4 —S(O) m —, (3) R 4 NHCO—, (4) R 4 CONH—, (5) R 4 R 5 N—, (6) nitrile, (7) NC—C 1-6 alkyl-, (8) halogen, (9) (10) R 3 is selected from the group consisting of: R 4 is selected from the group consisting of: (1) hydrogen, (2) C 1-6 alkyl, (3) phenyl, and (4) benzyl; R 5 is independently selected from the group consisting of: (1) hydrogen; (2) C 1-6 alkyl, (3) phenyl, (4) benzyl, and R 6a , R 6b , and R 6c are independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) —OR 5 , (4) —SR 5 , and (5) C 1-6 alkyl; R 7 is selected from the group consisting of —C═C—, O, S, and NH; R 8a and R 8b are independently selected from the group consisting of: (1) nitrile (2) hydrogen, (3) halogen, (4) —OR 5 , (5) —SR 5 , (6) C 1-6 alkyl, (7) —CO 2 R 5 , and (8) tetrazolyl; X 1 is hydrogen and X 2 is hydroxyl; n is independently 1, 2, 3, or 4; m is independently 0, 1, or 2; and pharmaceutically acceptable salts thereof.