Patent ID: 8309127

Claim:
A pharmaceutical composition comprising: a first layer comprising from 750 mg to 850 mg ibuprofen as an active pharmaceutical ingredient and a second layer comprising from 24 mg to 28 mg famotidine as an active pharmaceutical ingredient, wherein the active pharmaceutical ingredients are in direct contact, wherein the pharmaceutical composition is in the form of a tablet, provided that if the pharmaceutical composition is a table-in-tablet formulation, then the first layer completely surrounds the second layer, wherein the pharmaceutical composition is formulated for immediate release, and wherein none of the composition, the first layer, the second layer, the famotidine, or the ibuprofen is enterically coated or formulated for sustained release, wherein the pharmaceutical composition is formulated so that release of the ibuprofen active pharmaceutical ingredient and the famotidine active pharmaceutical ingredient begins to occur at about the same time, wherein the famotidine is not present as barrier coated famotidine multiparticulates dispersed in an ibuprofen matrix, wherein the direct contact between the famotidine active pharmaceutical ingredient and the ibuprofen active pharmaceutical ingredient is limited, and wherein at least 90% of the amount of ibuprofen initially present and at least 90% of the amount of famotidine initially present remains after the composition is stored at 40° C. and 75% relative humidity for a period of one month.