Patent ID: 7268136

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 is NR 3 R 4 ; wherein R 4 is hydrogen or optionally substituted C 1-4 alkyl and R 3 is an optionally substituted aryl, heteroaryl, cycloaliphatic, or heterocycloaliphatic group each occurrence of R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, and each occurrence of R′ is independently selected from hydrogen or an optionally substituted group selected from C 1-8 aliphatic, C 6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms, or wherein R and R′ taken together, or two occurrences of R′ on the same substituent or different substituents, taken together, form a 5-8 membered heterocyclyl or heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and R 2 is -(T) n Ar 1 , wherein T is NR; n is 0 or 1; Ar 1 is an optionally substituted group selected from wherein any substitutable carbon or nitrogen atom is optionally substituted and wherein x is 0-5, Q is a bond or is a C 1 -C 6 alkylidene chair wherein up to two non-adjacent methylene units of Q are optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each occurrence of R X is independently selected from R′, halogen, NO 2 , CN, OR′, SR′, N(R′) 2 , NR′C(O)R′, NR′C(O)N(R′) 2 , NR′CO 2 R′, C(O)R′, CO 2 R′, OC(O)R′, C(O)N(R′) 2 , OC(O)N(R′) 2 , SOR′, SO 2 R′, SO 2 N(R′) 2 , NR′SO 2 R′, NR′SO 2 N(R′) 2 , C(O)C(O)R′, or C(O)CH 2 C(O)R′; provided that: 1) R 2 is not nitro substituted pyrazolyl, nitro substituted furyl, or nitro substituted thiophene; 2) when R 1 is —NH(cyclopropyl), then R 2 is not phenyl substituted with one occurrence of CF 3 in the para position.