Patent ID: 8835398

Claim:
A method of inhibiting angiogenesis in an endothelial tissue of a subject in need thereof, the method comprising administering directly to the endothelial tissue or systemically to said subject a vector comprising: (a) a promoter functional in the endothelial tissue, which comprises a cis-acting regulatory element comprising the sequence as set forth in SEQ ID NOs: 15 and 16, SEQ ID NO: 15 being upstream of SEQ ID NO: 16 in the promoter, or the complementary sequences thereof; and (b) a nucleic acid sequence encoding an apoptosis inducing factor under control of said promoter, wherein said subject is being treated with radiation therapy, chemotherapy, or a combination thereof; and wherein said apoptosis inducing factor is expressed in or near the endothelial tissue and the expression of said apoptosis inducing factor downregulates angiogenesis in the endothelial tissue.