Patent ID: 6916850

Claim:
A compound represented by Formula Ia: wherein: the dashed line indicates a single or double bond; A is: substituted alkyl selected from: —CH 2 —CH (OH)—CH 2 —OH, —CH(CH 3 )—CH(OH)—CH 2 —OH, —CH(CH 3 )—C(O)—N(H)—CH 2 —COOH, —CH 2 —C(O)—N(H)—CH 2 —COOH, —CH 2 —CH 2 —C(O)—N(H)—CH 2 —COOH, —CH(CH 3 )—CH 2 —C(O)—N(H)—CH 2 —COOH, and —CH 2 —CH(CH 3 )—C(O)—N(H)—CH 2 —COOH, or A is: an optionally substituted di-, tri- or tetra-peptide; R is: hydrogen, optionally substituted alkyl, or optionally substituted cycloalkyl; X is: —S—, —S(O)—, —S(O) 2 —, or a covalent bond to the sulfur atom of Cys; and Z is: —OR, or a single tautomer, single stereoisomer, a mixture of tautomers and/or sterecisomers, or a pharmaceutically acceptable salt thereof.