Patent ID: 7365226

Claim:
A process for the preparation of gabapentin comprising passage of a salt of gabapentin through a column comprising an ionic exchange resin of strong cationic type, elution of the gabapentin which has fixed onto the column, crystallization from organic solvent, and regeneration of the ionic exchange resin, wherein regeneration is carried out, in order, as follows: a. by partially regenerating the resin by treating the resin with an aqueous regenerating solution of inorganic acid in a quantity equal to a percentage of resin moles of from 50 to 90% of the theoretical percentage required for complete regeneration of the resin; b. by adding demineralized water in a quantity sufficient to separate the regenerating solution from the solution of a gabapentin salt of item c.; c. by adding a solution of gabapentin salt and by completing the resin regeneration through the acid released by fixing the gabapentin salt to the resin; d. by eluting the gabapentin which has fixed to the resin by using a base.