Patent ID: 8440691

Claim:
A compound having formula (I): or a pharmaceutically acceptable salt thereof, wherein: A 1 is CR 1 ; A 2 is CR 2 ; A 3 is CR 3 ; A 4 is CR 4 ; R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of alkyl, alkenyl alkynyl haloalkyl, halogen, hydrogen hydroxy, alkoxy, —OR c , haloakoxy, —NR A R B , —C(O)R a ,—C(O)OH, —C(O)Oalkyl, —S(alkyl), —S(O)alkyl, —S(O) 2 R a , R c , —O-alkyl-R c and -alkyl-R c ; X is NR 5 ; Y is a bond; L is C 1-10 alkyl; R 5 is selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, —C(O)R a , —S(O) 2 R a , R c , and -alkyl-R c ; R a , is alkyl, haloalkyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , R c , or -alkyl-R c ; m is 2; n is 0; R 7 and R 8 , at each occurrence, are independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, and -alkyl-R c , wherein the aryl, heteroaryl, cycloalkyl and cycloalkenyl are each independently unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of alkyl, haloalkyl, halogen, hydroxy, alkoxy, haloalkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O))Oalkyl, —N(alkyl)C(O)Oalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , —S(alkyl), —S(O)alkyl, —S(O) 2 alkyl, —S(O) 2 N(H) 2 , —S(O) 2 N(H)(alkyl) and —S(O) 2 N(alkyl) 2 ; R 9 is hydrogen, alkyl, haloalkyl, hydroxy, alkoxy or haloalkoxy; R A and R B are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, R c and -alkyl-R c , Z is indazolyl that is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of alkyl, haloalkyl, halogen, hydroxy, alkoxy, haloalkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —C(O)alkyl, —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , —S(alkyl), —S(O)alkyl, —S(O) 2 alkyl, —S(O) 2 N(H) 2 , —S(O) 2 N(H)(alkyl), —S(O) 2 N(alkyl) 2 , R c , and alkoxyalkyl; and R c at each occurrence is independently a monocyclic or bicyclic ring, independently selected from the group consisting of cycloalkyl, cycloalkenyl, heterocycle, heteroarly and aryl; wherein each R c is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of alkyl, haloalkyl, halogen, oxo, hydroxy, alkoxy, haloalkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)Oalkyl, —N(alkyl)C(O)Oalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , —S(alkyl), —S(O)alkyl, —S(O) 2 alkyl, —S(O) 2 N(H) 2 , —S(O) 2 N(H)(alkyl) and —S(O) 2 N(alkyl) 2 .