Patent ID: 8785429

Claim:
A method for inhibition of JAK2 and/or JAK3 in a subject suffering from a disease associated with JAK2 and/or JAK3, the method comprising administering to the subject a compound of formula I or a pharmaceutically acceptable salt thereof, wherein: G 1 is selected from the group consisting of CR 8 ; R 1 is selected from the group consisting of optionally substituted C 3-8 cycloalkyl, optionally substituted C 3-6 heterocycloalkyl, optionally substituted C 4-14 aryl, optionally substituted C 1-10 heteroaryl, and optionally substituted C 1-6 alkyl; R 2 and R 3 are each independently selected from the group consisting of hydrogen and optionally substituted C 1-4 alkyl, or R 2 , R 3 , and the carbon atom to which they are attached form a carbonyl; R 4 is selected from the group consisting of hydrogen, optionally substituted C 1-4 alkyl, optionally substituted C 1-4 alkoxy, halo, hydroxy, and amino; R 5 is selected from the group consisting of hydrogen, optionally substituted C 1-4 alkyl, C 3-8 cycloalkyl, and halo; R 6 and R 7 are each independently selected from the group consisting of hydrogen and optionally substituted C 1-4 alkyl, or R 6 , R 7 , and the carbon atom to which they are attached form a carbonyl; R 8 is selected from the group consisting of hydrogen, optionally substituted C 1-6 alkyl, optionally substituted C 1-4 alkoxy, C 1-9 amide, C 1-5 oxycarbonyl, cyano, optionally substituted C 3-8 cycloalkyl, optionally substituted C 4-14 aryl, optionally substituted C 1-10 heteroaryl, and halo; and with the proviso that no more than one carbonyl is formed from R 2 and R 3 and R 6 and R 7 .