Patent ID: 8883208

Claim:
A medical device comprising: (A) a surface; (B) a controlled release coating disposed on the surface of the medical device, the controlled release coating comprising a first polymeric matrix comprising a first polymer having a first solubility; and (C) a plurality of nucleic acid delivery microparticles disposed within the controlled release coating, each nucleic acid delivery particle comprising: (i) a second polymeric matrix comprising a blend of a polyethyleneglycol copolymer having a second solubility and a degradable polyester; and (ii) a nucleic acid complex encapsulated within the second polymeric matrix to form the nucleic acid delivery microparticle, the nucleic acid complex comprising a nucleic acid and a carrier agent, the carrier agent comprising a peptide having a nucleic acid binding domain and a nuclear localization domain; wherein the first polymer matrix comprises polymers that are soluble in a non-polar solvent and the second polymer matrix comprises polymers soluble in a polar solvent.