Patent ID: 7772221

Claim:
A compound of Formula (I); or a stereoisomer thereof wherein R 1 is C 1-6 alkyl, phenyl or phenyl(C 1-4 alkyl) in which each group is optionally substituted with one or two groups selected from halogen, C 1-4 alkyl, OH, CF 3 , OCF 3 and CN; R 2 is hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 cycloalkyl or C 3-6 cyloalkyl(C 1-4 alkyl) in which each group is optionally substituted with a group selected from halogen, C 1-4 alkyl, OH, C 1-4 alkoxy, CF 3 , CF 2 H, OCF 3 and CN; or NHR 4 , NR 4 C(═O)R 5 , NR 4 C(═O)OR 5 or NR 4 S(═O) 2 R 5 ; R 3 is hydrogen, C 1-6 alkyl, phenyl or phenyl(C 1-4 alkyl) in which each group is optionally substituted with one to two groups selected from halogen, C 1-4 alkyl, OH, CF 3 , OCF 3 and CN; R 4 is hydrogen or C 1-6 alkyl; R 5 is C 1-6 alkyl, phenyl or thiophenyl in which each group is optionally substituted with one to two groups selected from halogen, C 1-4 alkyl, OH, CF 3 , OCF 3 and CN; m is 1 or 2; n is 1 or 2; W is CH 2 ; or W and R 3 are joined together to form the following ring system X is a bond or CH 2 ; or when W is CH 2 , X and R 3 are joined together to form the following ring system X and W are joined together to form the following ring system Y is a bond or C 1-3 alkyl; Z is a bond, oxygen or NR 8 ; R 6 and R 7 each are independently hydrogen, halogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cyloalkyl(C 1-4 alkyl), phenyl, 4-morpholinophenyl, C 1-6 alkoxy, OCF 3 , phenoxy, indanyl, pyrazoyl, piperizinyl, 4-(5-tert-butoxycarbonyl)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl), 5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl and pyrrolidinyl in which each group is optionally substituted with a group selected from halogen, C 1-4 alkyl, CF 3 , CF 2 H, OH, OCF 3 and C 1-4 alkoxy; R 8 is hydrogen, C 1-4 alkyl or C(═O)OR 9 ; R 9 is C 1-6 alkyl, phenyl or phenyl(C 1-4 alkyl); L is —CH(R 10 )—CH(R 11 ) or —C(R 10 )═C(R 11 )—; and R 10 and R 11 are each independently hydrogen or methyl; or a nontoxic pharmaceutically acceptable salt thereof.