Patent ID: 7799787

Claim:
A compound of structural formula I: or a pharmaceutically acceptable salt thereof; wherein each n is independently 0, 1, 2, or 3; each p is independently 0, 1, or 2; m is 2; q is 1 or 2; X—Y is CH—O, CH—S(O) p , CH—NR 6 , CH—C(R 1 R 2 ) q , or CH—C(O); Ar is phenyl, naphthyl, or heteroaryl unsubstituted or substituted with one to five R 8 substituents; R 1 and R 2 are each independently hydrogen or C 1-3 alkyl, wherein alkyl is unsubstituted or substituted with one to three substituents independently selected from fluorine and hydroxy; R 3 is independently selected from the group consisting of C(O)NR 4 R 5 , OC(O)NR 4 R 5 , SO 2 NR 4 R 5 , NR 7 SO 2 R 6 , NR 7 C(O)NR 4 R 5 , NR 7 C(O)R 6 , and NR 7 CO 2 R 6 ; in which cycloalkyl is unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, trifluoromethyl, and C 1-4 alkoxy; R 4 and R 5 are each independently selected from the group consisting of hydrogen, C 1-8 alkyl, (CH 2 ) n -phenyl, (CH 2 ) n -heteroaryl, (CH 2 ) n -naphthyl, and (CH 2 ) n C 3-7 cycloalkyl; wherein alkyl, phenyl, heteroaryl, and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from halogen, hydroxy, C 1-4 alkyl, and C 1-4 alkoxy; or R 4 and R 5 together with the nitrogen atom to which they are attached form a 4- to 8-membered mono- or bicyclic ring system optionally containing an additional heteroatom selected from O, S, NH, and NC 1-4 alkyl; each R 6 is independently C 1-6 alkyl, wherein alkyl is unsubstituted or substituted with one to five substituents independently selected from halogen and hydroxyl; R 7 is hydrogen or R 6 ; and each R 8 is independently selected from the group consisting of C 1-6 alkyl, (CH 2 ) n -phenyl, (CH 2 ) n -naphthyl, (CH 2 ) n -heteroaryl, (CH 2 ) n -heterocyclyl, (CH 2 ) n C 3-7 cycloalkyl, halogen, OR 4 , (CH 2 ) n NR 4 R 5 , (CH 2 ) n C≡N, (CH 2 ) n CO 2 R 4 , NO 2 , (CH 2 ) n NR 7 SO 2 R 6 , (CH 2 ) n SO 2 NR 4 R 5 , (CH 2 ) n S(O) p R 6 , (CH 2 ) n NR 7 C(O)NR 4 R 5 , (CH 2 ) n C(O)NR 4 R 5 , (CH 2 ) n NR 7 C(O)R 6 , (CH 2 ) n NR 7 CO 2 R 6 , O(CH 2 ) n C(O)NR 4 R 5 , CF 3 , CH 2 CF 3 , OCF 3 , and OCH 2 CF 3 ; in which phenyl, naphthyl, heteroaryl, cycloalkyl, and heterocyclyl are unsubstituted or substituted with one to three substituents independently selected from halogen, hydroxy, C 1-4 alkyl, trifluoromethyl, and C 1-4 alkoxy; and wherein any methylene (CH 2 ) carbon atom in R 8 is unsubstituted or substituted with one to two groups independently selected from halogen, hydroxy, and C 1-4 alkyl; or two substituents when on the same methylene (CH 2 ) group are taken together with the carbon atom to which they are attached to form a cyclopropyl group.