Patent ID: 8067370

Claim:
A wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequence which are cleavable by a kallikrein such that the rate of release of the therapeutic agent increases in the presence of the kallikrein, wherein the oligopeptidic sequence comprises -Phe-Arg-Ser-Ser-Arg-Gln- (SEQ ID NO: 1) or Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln (SEQ ID NO: 2), and wherein the polymers are selected from the group consisting of non-ionic surfactants, polyalkoylated alcohols, alkyl or dialkyl polyglycerols, polyethyloxylated alcohols, polymers of acrylamide, polynucleotides, polypeptides, carbohydrates, synthetic polymers, polyvinyl alcohols, polyethylene glycerol, PVP, polyolefins, fluoropolymers, vinyl esters, vinyl ethers, carboxy vinyl monomers, meth(acrylic) acid, acrylamide, N-vinyl pyrrolidone, acylamidopropanem acylamidopropane, maleic acid, N,N-dimethylacrylamide diacetone acrylamide acryloyl, morpholine, oxidized regenerated cellulose and polylactide/polyglycolide copolymers.