Patent ID: 7638519

Claim:
A compound having the Formula I: and pharmaceutically acceptable salts thereof, wherein: R 1 is NR 8 R 9 , wherein R 8 and R 9 are each H; R 2 is C 1-6 -alkyl, or C 1-6 -cycloalkyl; R 3 is phenyl, pyridine, pyrimidine, thiophene, furan, oxazole, isoxazole, thiazole, isothiazole, imidazole, pyrazole and pyrrole, and any of R 3 may be optionally substituted by one or more of halogen, NO 2 , CN, CF 3 , C 1-6 -alkyl, C 0-6 -alkyl-S, C 0-6 -alkyl-O, C 0-6 -alkyl-NH, (C 1-6 -alkyl) 2 -N, C 1-6 -alkyl-SO, C 1-6 -alkyl-SO 2 , SO 2 NH—C 0-6 -alkyl, SO 2 N(C 1-6 -alkyl) 2 , NHSO 2 —C 1-6 -alkyl, CONH—C 0-6 -alkyl, NHCO—C 1-6 -alkyl and COO—C 0-6 -alkyl; X and Y are null; R 4 and R 5 taken together form a thiophene, which may be optionally substituted by one or more of halogen, NO 2 , CN, CF 3 , C 1-6 alkyl, C 0-6 -alkyl-S, C 0-6 -alkyl-O, C 0-6 -alkyl-NH, C 1-6 -alkyl) 2 -N, C 1-6 -alkyl-SO, C 1-6 -alkyl-SO 2 , SO 2 NH—C 0-6 -alkyl, SO 2 N(C 1-6 -alkyl) 2 , NHSO 2 -C 1-6 -alkyl, CONH—C 0-6 -alkyl, NHCO—C 1-6 -alkyl and COO—C 0-6 -alkyl; R 6 and R 7 are null, H, or are independently but not simultaneously phenyl, pyridine, pyrimidine, thiophene, furan, oxazole, isoxazole, thiazole, isothiazole, imidazole and pyrazole, and any of R 6 or R 7 may be optionally substituted by one or more of halogen, NO 2 , CN, CF 3 , C 1-6 -alkyl, C 0-6 -alkyl-S, C 0-6 -alkyl-O, C 0-6 -alkyl-NH, (C 1-6 -alkyl) 2 -N, C 1-6 -alkyl-SO, C 1-6 -alkyl-SO 2 , SO 2 NH-C 0-6 -alkyl, SO 2 N(C 1-6 -alkyl) 2 , NHSO 2 —C 1-6 -alkyl, CONH—C 0-6 -alkyl, NHCO-C 1-6 -alkyl and COO-C 0-6 -alkyl; alkyl may be straight or branched chain; further comprising all isomers, positional isomers, diastereomers, enantiomers and salts thereof; and excluding 3-methyl-2-phenyl-5,6,7,8-tetrahydro-benzo[4,5]thieno [2,3-b]pyridin-4-ylamine.