Patent ID: 8143281

Claim:
A compound of formula (I-b) wherein R 1 is H, C 1-12 -alkyl, optionally substituted with CN or OH, C 1-6 -haloalkyl, C 2-12 -alkenyl, —(CR i R ii ) m —R a , wherein R i and R ii are independently from each other H, methyl, or ethyl; wherein m is from 0 to 4; wherein R a is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl or 3 to 7-membered cylcoalkyl, which are optionally substituted with one or more A, or —NR b R c , wherein R b and R c are each independently hydrogen, hydroxy, C 1-6 -alkyl, —S(O) 2 —C 1-6 -alkyl, or —C(O)—C 1-6 -alkyl, —(CR iii R iv ) n —C(O)R d , wherein R iii and R iv are independently from each other H, methyl, or ethyl; wherein n is from 0 to 4; wherein R d is C 1-6 -alkoxy, —NR e R f , wherein R e and R f are each independently hydrogen, C 1-6 -alkyl, or —(C 2-6 -alkylene)NR g R h ; wherein R g and R h are each independently hydrogen, C 1-6 -alkyl, or —C(O)O—C 1-6 -alkyl, phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl or 3 to 7-membered cycloalkyl, which are optionally substituted with one or more A, —S(O) 2 -phenyl, wherein phenyl is optionally substituted with one or more halo, C 1-6 -haloalkyl, C 1-6 -alkoxy, C 1-6 -haloalkoxy, nitro, hydroxy or cyano; —S(O) 2 —C 1-6 -alkyl, —S(O) 2 N(C 1-6 -alkyl) 2 , —S(O) 2 NH(C 1-6 -alkyl); A is halo, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -hydroxyalkyl, C 1-6 -cyanoalkyl, C 1-6 -alkoxy, C 1-6 -haloalkoxy, —S(O) 0-2 C 1-6 -alkyl, nitro, hydroxy, cyano, —(C 1-6 -alkylene)-O—C 1-6 -alkyl, —(C 1-6 -alkylene)-O—C 1-6 -haloalkyl, —(C 1-6 -alkylene)-OR′″, —C(O)OC 1-6 -alkyl, —C(O)OR′″, —C(O)R′″, —C(O)NR′R″, —S(O) 2 NR′R″, —(CH 2 ) x —NR′R″, —(CH 2 ) x —NR′C(O)—C 1-6 -alkyl, —(CH 2 ) x —NR′S(O) 2 —C 1-6 -alkyl, —(CH 2 ) x —C 3-6 -cycloalkyl, —(CH 2 ) x —R′″, wherein x is from 0 to 4, R′ and R″ are each independently H or C 1-6 -alkyl, or R′ and R″ together with the nitrogen to which they are bound form a 5 or 6-membered heterocycle comprising one or two heteroatoms selected from N, O and S, and R′″ is phenyl or 5- to 6-membered heteroaryl, optionally substituted with one, two, or three halo, C 1-6 -haloalkyl, C 1-6 -alkyl, or C 1-6 -alkoxy, R 2 is hydrogen, C 1-6 -alkyl, —C(O)R n , wherein R n is C 1-6 -alkyl, 3 to 7-membered heterocycloalkyl, optionally substituted with one, two or three C 1-6 -alkyl, —C(O)O—C 1-6 -alkyl, or —S(O) 2 —C 1-6 -alkyl, NR j R k , wherein R j and R k are each independently hydrogen, C 1-6 -alkyl, —(C 2-6 -alkylene)-NR l R m ; wherein R l and R m are each independently hydrogen, C 1-6 -alkyl, or —C(O)O—C 1-6 -alkyl; or R 3 , R 4 , R 5 , R 6 are each independently hydrogen, halo, C 1-6 -alkyl, halo-C 1-6 -alkyl, C 1-6 -alkoxy or C 1-6 -haloalkoxy; R 7 , R 8 , R 9 , R 10 are each independently hydrogen, halo, C 1-6 -alkyl, halo-C 1-6 -alkyl, C 1-6 -alkoxy or C 1-6 -haloalkoxy; or a pharmaceutically acceptable salt thereof, with the proviso that compounds wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are all simultaneously hydrogen are excluded.