Patent ID: 8168787

Claim:
A process for the preparation of one or more compounds of Formula 1 or salts thereof, in which R 1 represents amino, nitro, halogen, hydroxy, NHC(O)R 3 , NHR 4 , R 3 represents 4-(halo-methyl)phenyl, 4-(hydroxymethyl)phenyl, 4-((4-methylpiperazinyl)carbonyl)phenyl, 4-(alkoxycarbonyl)phenyl, or 4-[(4-methyl-1-piperazinyl)methyl]phenyl, wherein alkoxy means C 1 -C 4 alkoxy, R 4 represents a protecting group for the amine group, comprising the steps of: a) reacting the β-oxo-3-pyridinepropanal, a salt thereof, or compound of Formula 17 wherein R 2 represents hydrogen, C 1 -C 4 alkyl, benzyl, or phenyl, with an aryl guanidine of Formula 3 wherein R 1 has the meaning described above, to yield the compound of Formula 19 in which R 1 has the foregoing meaning, and b) cyclizing the intermediate of Formula 19 in the presence of a base.