Patent ID: 8906864

Claim:
An isolated neogenin receptor-binding domain derived from a human RGM A as shown in SEQ ID NO:2, comprising an amino acid sequence from amino acid position 200 to 350 as shown in SEQ ID NO: 2, or from amino acid position 200 to 325 as shown in SEQ ID NO: 2, or from amino acid position 200 to 300 as shown in SEQ ID NO: 2, or from amino acid position 200 to 285 as shown in SEQ ID NO: 2, or from amino acid position 250 to 285 as shown in SEQ ID NO: 2, or from amino acid position 260 to 285 as shown in SEQ ID NO: 2, or from amino acid position 215 to 340 as shown in SEQ ID NO: 2, or from amino acid position 260 to 340 as shown in SEQ ID NO: 2, or from amino acid position 250 to 300 as shown in SEQ ID NO: 2, or from amino acid position 260 to 291 as shown in SEQ ID NO: 2, or from amino acid position 210 to 260 as shown in SEQ ID NO: 2, or from amino acid position 290 to 350 as shown in SEQ ID NO: 2, or from amino acid position 218 to 284 as shown in SEQ ID NO: 2, or from amino acid position 266 to 335 as shown in SEQ ID NO: 2, or from amino acid position 168 to 422 as shown in SEQ ID NO: 2, or SEQ ID NO: 8, or SEQ ID NO: 26, or SEQ ID NO: 27, or a functional, neogenin receptor-binding fragment thereof.