Patent ID: 7358248

Claim:
A compound of the formula and pharmaceutically acceptable salts thereof, wherein R 1 is H, C 1 -C 6 alkyl, phenyl(C 1 -C 6 )alkyl, or C 3 C 6 alkenyl; R 6 and R 7 are independently H, C 1 -C 6 alkyl, aryl(C 1 -C 6 )alkyl, (C 1 -C 8 )alkanoyl optionally substituted with 1 or 2 groups independently selected from amino, mono or dialkylamino, —NHaryl, —N(C 1 -C 6 alkyl)aryl, and CO 2 H,aryl(C 1 -C 6 )alkanoyl, (C 1 -C 6 ) alkoxycarbonyl, arylalkoxycarbonyl, heteroarylcarbonyl, heteroaryl, heterocycloalkylcarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl (C 1 -C 6 )alkyl, —C(═NH)NH 2 , —C(═N—C(O)C 1 -C 6 alkoxy)NH—C(O)C 1 -C 6 alkoxy, or —SO 2 -aryl, wherein the cyclic portions of each of the above are optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, NO 2 , OH, CO 2 H, CN, C 2 -C 6 alkanoyl, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, haloalkyl or haloalkoxy; R 20 , R 21 , R 22 , and R 23 are independently selected from H, arylalkoxy, arylalkyl, halogen, alkyl, OH, alkoxy, NO 2 , NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, NHaryl, N(C 1 -C 4 )alkyl-aryl, —NHSO 2 -aryl, —N(C 1 -C 4 alkyl)SO 2 aryl, wherein the aryl group is optionally substituted with 1, 2, 3, or 4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, OH, NO 2 , C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy; L 2 is a bond; L 3 is a bond, —(C 1 -C 4 )alkyl-O—, —O—(C 1 -C 4 )alkyl, —(C 1 -C 4 )alkyl-, —C 2 -C 6 alkenyl, —C(O)—, —(C 1 -C 4 )alkyl-O—, —C(O)NH—, or —NHC(O)—; L 4 —(C 1 -C 4 )alkyl-S(O) u —(C 1 -C 4 )alkyl-; wherein u is 0, 1, or 2; the A-ring is phenyl, naphthyl, isoindolyl, indolyl, benzofuranyl, or benzimidazolyl, each of which is optionally substituted with 1, 2, 3, or 4 groups that are independently, halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 C 4 haloalkyl, C 1 -C 4 haloalkoxy, NO 2 , NH 2 , NH(C 1 -C 6 )alkyl, or N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl; Q is -heteroaryl-(C 1 -C 4 )alkyl-aryl, -aryl-(C 1 -C 4 )alkyl-heteroaryl, heteroaryl, or aryl, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently alkoxycarbonyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, C 1 -C 6 alkanoyl, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl (C 1 -C 6 )alkyl, phenyl, C 1 C 6 alkanoyl; Q 2 is and H or aryl, wherein the aryl is optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, or halogen; and Y and Y′ are independently a bond or (C 1 -C 4 )alkyl-.