Patent ID: 7704529

Claim:
A stable, phase-pure magnesium-substituted crystalline hydroxyapatite comprising from about 10 wt % to about 29 wt % magnesium, wherein at least 80 wt % of the magnesium content of said magnesium-substituted hydroxyapatite is substituted for calcium ions in the hydroxyapatite lattice structure, wherein said magnesium-substituted hydroxyapatite is made by a process comprising the step of mechanochemically comminuting and dissolving while hydrothermally reacting without external heating a source of calcium ions, a source of magnesium ions, a source of phosphate ions and a source of hydroxide ions, at least one of which is soluble in water, in a aqueous reaction medium until said magnesium substituted-hydroxyapatite is formed, wherein at least one of said source of calcium ions, source of magnesium ions, source of phosphate ions and source of hydroxide ions is water-insoluble or forms a water-insoluble apatite precursor.