Patent ID: 7368111

Claim:
An isolated antibody or antibody fragment thereof comprising an antibody-antigen binding domain of a human antibody specific for TGFβ isoform TGFβ2, said antibody-antigen binding domain comprising; (a) a VH domain selected from the group consisting of the 6H1 VH domain of which the amino acid sequence is shown in FIG. 2( a )(i) (SEQ ID NO: 6), the 11E6 VH domain of which the amino acid sequence is shown in FIG. 2( a )(ii) (SEQ ID NO: 37), the Gold 11-VH domain of which the amino acid sequence is shown in FIG. 2( a )(iii) (SEQ ID NO: 116), the 1-G2 VH domain of which the amino acid sequence is shown in FIG. 2( a )(v) (SEQ ID NO: 120) and the 1-H-6 VH domain of which the amino acid sequence is shown in FIG. 2( a )(vi) (SEQ ID NO: 122); and (b) a VL domain selected from the group consisting of the 6B1 VL domain of which the amino acid sequence is shown in FIG. 2( b )(iii) (SEQ ID NO:43), the 6H1 VL domain of which the amino acid sequence is shown in FIG. 2( b )(i) (SEQ ID NO: 39), the 6A5 VL domain of which the amino acid sequence is shown in FIG. 2( b )(ii) (SEQ ID NO:41), the 11E6 VL domain of which the amino acid sequence is shown in FIG. 2( b )(iv) (SEQ ID NO:45), the 14F12 VL domain of which the amino acid sequence is shown in FIG. 2( b )(v) (SEQ ID NO:47) and the 6H1 VL domain of which the amino acid sequence is shown in FIG. 2( b )(vi) (SEQ ID NO:124).