Patent ID: 7220766

Claim:
3-Phenylpropionic acid derivatives of formula (I): wherein: W represents COOH group or its bioisosters, or —COO—C 1 –C 4 -alkyl group; Y represents NH, N—C 1 –C 10 -alkyl, O, or S; X represents O or S; each of R 1 to R 8 independently represents hydrogen atom or a substituent selected from the group consisiting of: C 1 –C 4 -alkyl, C 1 –C 4 -alkoxy, C 3 –C 7 -cycloalkyl, C 3 –C 7 -cycloalkoxy, C 1 –C 4 -thioalkoxy, C 3 –C 7 -cyclothioalkoxy, halogen atom, halogen-substituted C 1 –C 4 -alkyl, halogen-substituted C 3 –C 7 -cycloalkyl, aryl, heteroaryl, —NO 2 , —CN, —SO 2 —NH 2 , —SO 2 —NH—(C 1 –C 4 )-alkyl, —SO 2 —N(C 1 –C 4 -alkyl) 2 , —CO—(C 1 –C 4 )-alkyl, —O—CO—(C 1 –C 4 )-alkyl, —CO—O—(C 1 –C 4 )-alkyl, —CO-aryl, —CO—NH 2 , —CO—NH—(C 1 –C 4 )-alkyl, and —CO—N(C 1 –C 4 -alkyl) 2 ; A represents C 1 –C 4 -alkyl, C 3 –C 7 -cycloalkyl, halogen-substituted C 3 –C 7 -cycloalkyl, aryl, heteroaryl, heterocyclyl, —NH—CO—(C 1 –C 4 )-alkyl, —N(C 1 –C 4 -alkyl)-CO—(C 1 –C 4 )-alkyl, —NH—CO-aryl, —N(C 1 –C 4 -alkyl)-CO-aryl, —N(C 1 –C 4 -alkyl)-CO—(C 3 –C 7 )-cycloalkyl, —NH—CO—NH 2 , —NH—CO—NH—(C 1 –C 4 )-alkyl, —NH—CS—NH—(C 1 –C 4 )-alkyl, —NH—CO—NH-aryl, —NH—CS—NH-aryl, —SO 2 —(C 1 –C 4 )-alkyl, —SO 2 -aryl, or —SO 2 -heteroaryl; wherein aryl, heteroaryl and heterocyclyl are optionally substituted with one or more substituents independently selected from the group consisting of C 1 –C 4 -alkyl, C 1 –C 4 -alkoxy, C 1 –C 4 -thioalkoxy, ethylenedioxy, CN, halogen, and phenyl, said phenyl being optionally substituted with one or more substituents independently selected from C 1 –C 4 -alkyl, C 1 –C 4 -alkoxy, and halogen atom; and n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof.