Patent ID: 8129424

Claim:
A compound of the formula: wherein spacer is Y is CH or N, provided that if Y is CH then n is 0-2; if Y is N then n is 2-4; if Y is CH then R 1 and R 2 taken together are —(CH 2 ) a —NR 11 —(CH 2 ) 2 — where a is 1-2 which when taken together with Y form a piperidine or pyrrolidine ring which is optionally substituted with 1-3 groups selected from fluoro, fluoroalkyl, (C 1 -C 4 )alkyl, alkoxy, aryl, (C 3 -C 7 )cycloalkyl, heterocycloalkyl containing 1-2 hetero atoms selected from (O, S) and (C 1 -C 5 )alkyl-O—(C 1 -C 5 )alkyl; and if Y is N then R 1 and R 2 independently are (C 1 -C 5 )alkyl or (C 3 -C 6 )cycloalkyl, or R 1 and R 2 taken together with the nitrogen to which they are attached form a 5-7 member heterocyclic ring system with 0-1 additional hetero atoms selected from O and S which is optionally substituted with 1-3 (C 1 -C 5 )alkyl, fluoroalkyl or (C 3 -C 6 )cycloalkyl groups, or R 1 and R 2 taken together are —(CH 2 ) a —NR 11 —(CH 2 ) 2 —, where a is 2-3, which when taken together with Y form a piperazine or homopiperazine ring which is optionally substituted with 1-3 groups selected from fluoro, fluoroalkyl, (C 1 -C 4 )alkyl, alkoxy, aryl, (C 3 -C 7 )cycloalkyl, heterocycloalkyl containing 1-2 hetero atoms selected from (O, S) and (C 1 -C 5 )alkyl-O—(C 1 -C 5 )alkyl; R 3 is 0-2 of groups selected from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 6 )alkyl, heterocycloalkyl containing 1-3 hetero atoms selected from (O, S) and (C 1 -C 3 )alkyl-O—(C 1 -C 5 )alkyl; R 4 and R 5 are selected independently from H, (C 1 -C 5 )alkyl, (C 1 -C 8 )alkoxy, (C 1 -C 5 )alkyl-O—(C 1 -C 5 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, CF 3 and halogen; R 6 is CONR 7 R 8 , —(CH 2 ) x —O—R 9 , alkyl, fluoroalkyl or SO 2 NR 7 R 8 ; x is 1-4; R 7 and R 8 independently are hydrogen, (C 1 -C 5 )alkyl or (C 3 -C 6 )cycloalkyl, or R 7 and R 8 together with the nitrogen to which they are attached form a 5-7 member heterocyclic ring system with 0-1 additional hetero atoms selected from O, S and N(R 10 ), wherein the resulting ring is optionally substituted with 1-3 (C 1 -C 5 )alkyl or (C 3 -C 6 )cycloalkyl groups; R 9 is hydrogen, (C 1 -C 5 )alkyl, (C 3 -C 7 )cycloalkyl or aryl; R 10 is (C 1 -C 5 )alkyl, (C 1 -C 8 )alkoxy, (C 1 -C 5 )alkyl-O—(C 1 -C 5 )alkyl, (C 3 -C 6 )cycloalkyl or aryl; and R 11 is (C 1 -C 5 )alkyl, fluoroalkyl or (C 3 -C 6 )cycloalkyl and the pharmaceutically acceptable salts, and individual stereoisomers thereof.