Patent ID: 7994309

Claim:
A double-stranded ribonucleic acid (dsRNA) for selective inhibition of expression of a mutant target gene, the dsRNA comprising: two separate non-linked RNA strands, wherein a first strand of the dsRNA has a complementary region that is substantially complementary to less than 26 contiguous nucleotides of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA is complementary to the first strand, wherein the first and second strand of the dsRNA are 19 to less than 30 nucleotides in length, wherein the complementary region of the first strand of the dsRNA contains one mismatch relative to the mutant target gene and at least two mismatches relative to a wild type form of the target gene, and wherein the dsRNA inhibits expression of the mutant target gene in said cell without inhibiting expression of the wild-type form of the target gene.