Patent ID: 8188083

Claim:
A compound of formula (I) pharmaceutically acceptable salts thereof or isomers thereof wherein A is heteroaryl or heterocyclyl; R 1 is —C(O)—(C 1 -C 6 ) optionally substituted alkyl, —C(O)—O—(C 1 -C 6 ) optionally substituted alkyl, —NR a R b , —(C 1 -C 6 )alkyl —NR a —S(O) 2 —(C 1 -C 6 )alkyl or —(C 1 -C 6 )alkyl —NR a —C(O)—(C 1 -C 6 )alkyl; or R 1 is optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 2 -C 6 )alkenyl, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; R 2 for each occurrence is independently H, OH, oxo, —(CR a R b ) x —NR a —C(O)—NR a —(C 3 -C 6 )cycloalkyl-phenyl or —(CR a R b ) x —NR a R b ; or R 2 for each occurrence is independently optionally substituted (C 1 -C 6 )alkyl, —(CH 2 ) x — optionally substituted aryl, —(CH 2 ) x —(C 3 -C 6 ) optionally substituted cycloalkyl, —(CH 2 ) x — optionally substituted heteroaryl, or —(CH 2 ) x — optionally substituted heterocyclyl; wherein R 2 can replace hydrogen on either nitrogen or carbon; R 3 is aryl optionally substituted with one or more substituents; R 4 for each occurrence is independently H, OH, halo or optionally substituted (C 1 -C 4 )alkyl; R a and R b are independently H or optionally substituted (C 1 -C 6 )alkyl; m is 1 or 2; n is 0, 1 or 2; and x for each occurrence is independently 0, 1 or 2; provided that the compound is not wherein R 1 is methyl, ethyl, propyl, isopropyl, t-butyl, cyclopropyl, cyclohexyl, C 2 F 5 , CF 3 , or 4-fluorophenyl; provided that the compound is not wherein R 1 is CF 3 , CH 3 , NH 2 or phenyl optionally substituted with Br or F; R 2 is H or CH 3 ; and R 3 is phenyl optionally substituted with F; provided the compound is not wherein R 1 is phenyl substituted with F; R 2 is CN or NH 2 ; and R 3 is phenyl optionally substituted with three F; provided that the compound is not wherein R 1 is CF 3 , CH 3 or phenyl optionally substituted with F; and R 3 is phenyl optionally substituted with CH 3 , F or two OCH 3 ; provided that the compound is not wherein R 3 is phenyl substituted with three OCH 3 or phenyl substituted with two OCH 3 and one OH; provided that the compound is not wherein R 1 is CH 3 , CF 3 , —CH 2 CH 2 OH or phenyl optionally substituted with B, Cl or F; and R 3 is phenyl optionally substituted with OCH 3 , CF 3 , F, isopropyl, Cl or one or two CH 3 ; or R 1 is phenyl substituted with four F and one CF 3 ; and provided the compound is not