Patent ID: 7214668

Claim:
An isolated compound of Formula III: or a pharmaceutically acceptable salt thereof, wherein: MPO 3 H 2 is a phosphonic acid selected ftom the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxypropyl)adenine, 9-(2-phosphonylmethoxyethyloxy)adenine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, and (S)-9-(3-fluoro-2-phosphonyl-methoxypropyl) adenine; V is selected from the group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1–3 substituents selected from the group consisting of F, Cl, Br, C1–C3 alkyl, CF 3 and OR 6 ; and R 6 is selected from the group consisting of C1–C3 alkyl, and CF 3 ; wherein said compound has S stereochemistry where V is attached and is isolated apart from the corresponding stereoisomer having R stereochemistry where V is attached, and wherein said compound has greater than 96% diastereomeric purity.