Patent ID: 8246954

Claim:
A method for treating or alleviating the effects of a disease or disorder associated with amyloid plaque formation, said method comprising administering to an animal or a human in need thereof an antibody or a fragment thereof capable of specifically binding beta-amyloid peptide, wherein said antibody or fragment thereof comprises: (i) human- or primate-derived framework regions, (ii) a Heavy Chain Variable Region (HCVR) CDR1 having the amino acid sequence of SEQ ID NO: 1, (iii) an HCVR CDR2 having the amino acid sequence of SEQ ID NO: 2, (iv) an HCVR CDR3 having the amino acid sequence of SEQ ID NO: 3, and (v) a Light Chain Variable Region (LCVR) comprising an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ ID NO: 12, wherein the LCVR comprises an LCVR CDR2 having the amino acid sequence of SEQ ID NO: 5 or the amino acid sequence of SEQ ID NO: 5 with one amino acid substitution; and wherein at least one of the effects of the disease or disorder associated with amyloid plaque formation is treated or alleviated.