Patent ID: 8524691

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt, metabolite, solvate or prodrug thereof: wherein: A is a Rifamycin; L is a cleavable linker for coupling A to B; B is a phosphonated group selected from the group consisting of: wherein: each R* is independently selected from the group consisting of H, lower alkyl, cycloalkyl, aryl and heteroaryl, with the proviso that at least two R* are H; X is H, OH, NH 2 , or a halo group; and X 1 are both H, or each; and n is 1, 2, 3, 4, 5, 6 or 7, wherein each B-L- is independently selected from the group consisting of: wherein, Q 1 is —O— or —S—; Q 2 is —O—, —S— or —N(R L )—; Q 3 is —O—, —S—, —N(R L )— or —CH 2 —; Q 4 is —O—, —S—, —N(R L )—, —CH 2 — or a covalent bond; each R is independently selected from the group consisting of chloro, bromo, fluoro, iodo, nitro, trifluoromethyl and C m H l , where m is an integer such that 0≦m≦6 and l is an integer ≦2m+1; each R L is C m H l , where m is an integer such that 0≦m≦6 and l is an integer ≦2m+1; x is 1, 2, 3 or 4; and y is an integer <10.