Patent ID: 7199105

Claim:
A compound of formula (I): wherein: R 1 is alkyl; R 2 and R 3 are independently H, alkyl, hydroxy, fluoro, or cyanoalkyl or one of R 2 and R 3 is ═NOR 7 and the other is absent, or one of R 2 and R 3 is ═CH 2 and the other is absent, with the provisos that both R 2 and R 3 are not H; when one of R 2 and R 3 is fluoro, the other is not hydrogen or hydroxy; and when one of R 2 and R 3 is hydroxy, the other is not fluoro, hydrogen, or hydroxy; R 6 is selected from the group consisting of H, alkyl, hydroxyalkyl, —C(O)O-alkylene-cycloalkyl, —C(O)O-alkylene-substituted cycloalkyl, —C(O)O-alkyl, —C(O)O-substituted alkyl, —C(O)O-aryl, —C(O)O-substituted aryl, —C(O)O-heteroaryl, —C(O)O-substituted heteroaryl, —[C(O)O] p -alkylene-heterocycle, —[C(O)O] p -alkylene-substituted heterocycle, wherein p is 0 or 1; R 7 is H or alkyl; R 9 , which can be singly or multiply substituted in the ring on the same or different carbons, is independently selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkoxyalkoxy, cycloalkyl, substituted cycloalkyl, —OR d , —NR e R f , halogen, phenyl, substituted phenyl, —(CH 2 ) n —OH, —(CH 2 ) n —NR 4 R 5 , -alkylene-R a where R a is selected from monofluorophenyl and monochlorophenyl, and branched chain isomers thereof, wherein n is an integer of from 1 to 8 inclusive and R 4 and R 5 are H or alkyl, wherein R d is selected from the group consisting of alkyl, haloalkyl, alkenyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl, and wherein R e and R f are independently selected from the group consisting of H, alkyl, haloalkyl, alkenyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; and m is 0, 1, 2 or 3; or a prodrug, tautomer, or a pharmaceutically acceptable salt thereof; with the proviso that the compound of formula I has a minimum inhibition concentration of 32 μg/mL or less against at least one of the organisms selected from the group consisting of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Enterococcus faccium, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coil, Bacteroides fragilis, Bacteroides thetaiotaomicron , and Clostridium difficile.