Patent ID: 7022710

Claim:
A method of antagonizing A 1 adenosine receptors in a mammal in order to treat a disease state chosen from renal failure, renal dysfunction, nephritis, hypertension, edema, stress, depression, cardiac arrhythmia, impairment of cardiac function, congestive heart failure, and ischemia-induced injury of the brain, heart and kidney, comprising administering to a mammal a therapeutically effective dose of a compound having the structure of Formula I wherein: R 1 is optionally substituted C 1-14 alkyl; Y is C 1-14 alkylene; and Z is phenyl that is optionally substituted with halo, hydroxy, amino, cyano, or optionally substituted C 1-4 alkyl, or a pharmaceutically acceptable salt, ester, or prodrug thereof.