Patent ID: 7390926

Claim:
A process for the diastereoselective alkylation of a optically active nopinone to form a compound of formula (I) according to scheme A below: in which: R is a C 1-15 alkyl group; R 1 is selected from the group consisting of a C 1-15 alkyl; a C 1-15 alkyl substituted by a C 1-15 alkyl; ; a C 1-15 alkyl substituted by a C 1 -C 15 alkoxy; a C 2-15 alkenyl; a C 2-15 alkenyl substituted by a C 1-15 alkyl; ; a C 2-15 alkenyl substituted by a C 1 -C 15 alkoxy ; a C 2-15 alkynyl group; a C 2-15 alkynyl group substituted by a C 1-15 alkyl; a C 2-15 alkynyl group substituted by a C 1 -C 15 alkoxy; a C 5-15 aryl; an alkyl(C 1 -C 15 ) ester group; an alkyl(C 1-15 ) aldehyde group; a C 1 -C 15 acyl group; a C 5-15 aryloxy; an arylalkoxy; a silyloxy; an alkylcarbonyloxy; a benzylcarbonyloxy; a heterocycloalkoxy; and —CH 2 CH 2 —OR2, wherein R2 is is a C 1-15 alkyl group; a C 1-15 alkyl substituted by a C 1-15 alkyl; a C 1-15 alkyl substituted by a phenyl; a C 1-15 alkyl substituted by a halogen atom; a C 1-15 alkyl substituted by an alkoxy; a C 5-15 aryl; a C 1-15 alkylaryl; a silyl; a silyl substituted by a C 1-15 alkyl; a silyl substituted by a phenyl; a silyl substituted by an halogen atom; a silyl substituted by an alkoxy; an alkylcarbonate; an alkylcarbonate substituted by a phenyl ; an alkylcarbonate substituted by an halogen atom; an alkylcarbonate substituted by an alkoxy; a benzylcarbonate; a benzylcarbonate substituted by a C 1-15 alkyl; a benzylcarbonate substituted by a phenyl; a benzylcarbonate substituted by a halogen atom; a benzylcarbonate substituted by an alkoxy; a heterocycloalkoxy, a heterocycloalkoxy substituted by a C 1-15 alkyl; a heterocycloalkoxy substituted by a phenyl; and a heterocycloalkoxy substituted by a halogen atom; X is a halogen atom; and the configuration of the compound of formula (I) is selected from the group consisting of (E), (Z) and a mixture of (E) and (Z).