Patent ID: 7271193

Claim:
A compound of general formula (Ic), or a stereoisomer, optical isomer, pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof wherein R 1 is phenyl, which is unsubstituted or substituted by 1, 2, or 3 identical or different substituents selected from: halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, nitro, NR 9 R 10 , SR 11 , trifluoromethyl, hydroxyl, cyano, carboxy, C 1 -C 4 -alkoxycarbonyl and —C 1 -C 4 -alkylenehydroxyl, or is a heterocycle, which is a saturated, partially unsaturated or aromatic ring containing 5 or 6 ring atoms of which 1, 2 or 3 are identical or different heteroatoms selected from: nitrogen, oxygen, sulfur, and phosphorus, and where the heterocycle is unsubstituted or substituted by 1, 2, or 3 identical or different substituents selected from: halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, nitro, NR 9 R 10 , SR 11 , trifluoromethyl, hydroxyl, cyano, carboxy, —C 1 -C 4 alkoxycarbonyl and —C 1 -C 4 -alkylenehydroxyl; R 2 is hydrogen, C 1 -C 6 -alkyl, phenyl, which is unsubstituted or substituted by 1, 2, or 3 identical or different substituents selected from: halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, nitro, NR 9 R 10 , SR 11 , trifluoromethyl, hydroxyl, cyano, carboxy, C 1 -C 4 -alkoxycarbonyl and —C 1 -C 4 -alkylenehydroxyl, OR 11 , halogen, cyano, nitro, NR 9 R 10 or SR 11 ; R 3 , R 4 and R 5 are each independently selected from: hydrogen, C 1 -C 4 -alkyl, halogen, OR 11 , C 1 -C 4 -alkylcarbonyloxy, NR 9 R 10 , SO 2 NR 9 R 10 , carboxyl, cyano and nitro; Z is O or S; A is a saturated or unsaturated 5-membered ring and represented by any one of the general structures (i) to (v); wherein X 1 and X 2 are each independently selected from: a carbon atom and a nitrogen atom, provided that at least one of X 1 and X 2 is a nitrogen atom, wherein the nitrogen atom is at least monosubstituted by R 13 , wherein R 13 is selected from: hydrogen, unsubstituted C 1 -C 6 -alkyl, or C 1 -C 6 -alkyl substituted by halogen, hydroxyl or carboxyl, C 2 -C 6 -alkenyl, hydroxyl, C 1 -C 6 -alkoxy, C 1 -C 4 -alkylcarbonyl, toluenesulfonyl, cyano, SO 2 R 10 , —CO(CH 2 ) m R 14 and phenyl, which is unsubstituted or substituted by 1, 2, or 3 identical or different substituents selected from: halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, nitro, NR 9 R 10 , SR 11 , trifluoromethyl, hydroxyl, cyano, carboxy, C 1 -C 4 -alkoxycarbonyl and —C 1 -C 4 -alkylenehydroxyl; R 6 is —C 1 -C 4 -alkyleneOR 11 ; R 9 and R 10 are each independently selected from: hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkanoyl, C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkylcarbonyl, carboxamide and sulfonamide; R 11 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkanoyl, or C 1 -C 4 -alkoxycarbonyl; R 14 is hydrogen, C 1 -C 4 -alkyl, hydroxyl, —NR 9 R 10 halogen, —SH, or —S—C 1 -C 4 -alkyl; and m is an integer of 0 to 6.