Patent ID: 8748375

Claim:
A method for reducing body fat or body fat gain in a subject in need of treatment while maintaining or increasing lean body mass; of altering a body composition of a subject in need of treatment, wherein body fat is reduced and lean body mass is maintained or increased; for reducing body weight in a subject in need of, or desirous of, weight reduction; or for reducing caloric intake in a subject in need of reduction thereof, the method comprising administering an effective amount to the subject an amylin agonist, wherein the amylin agonist comprises the sequence set forth in SEQ ID NO:138, thereby reducing body fat or body fat gain while maintaining or increasing lean body mass; altering a body composition while reducing body fat and maintaining or increasing lean body mass; reducing body weight; or reducing caloric intake, wherein the amylin agonist is administered in a manner sufficient to maintain an average plasma concentration of the amylin agonist of at least about 50 pg/mL for a period of time selected from the group consisting of at least about 1 hr, at least about 2 hrs, at least about 3 hrs, at least about 4 hrs, at least about 5 hrs, at least about 6 hrs, at least about 7 hrs, at least about 8 hrs, at least about 12 hrs, at least about 1 day, at least about 2 days, at least about 3 days, at least about 1 week, at least about 2 weeks, and at least about 1 month.