Patent ID: 7615629

Claim:
A universal homogeneous solid support comprised of two or more independently selected universal linker subsets, each universal linker subset being independently covalently attached to a solid phase by a spacer moiety S, each universal linker subset comprising an anchor group, the anchor groups of two or more of the universal linker subsets being protected with protective groups selected from the group consisting of methoxyethylidene, dimethoxytrityl, levulinyl and 9-fluorenylmethoxycarbonyl that are orthogonal to each other, wherein the universal linkers are selected from the group of compounds having the following formula: wherein S is selected from the group consisting of (a) —C(═O)—, (b) a diacyl moiety selected from the group consisting of oxalyl, malonyl, succinyl, and glutaryl, (c) a dialkyl moiety selected from methylidene, ethylidene and propylidene, (d) a alkylacyl moiety selected from —C(═O)—CH 2 —, —CH 2 —C(═O)—, —C(═O)—CH 2 —CH 2 — and —CH 2 —CH 2 —C(═O)—, —P(═O)(OH)— and (d) a protected phosphate moiety selected from compounds having the formula —P(═O)(OR 6 )—, wherein R 6 is a phosphate protective group; Z is selected from the group consisting of a nucleobase, a hydrogen atom, and a methoxy group; and R 3 and R 4 are selected from the group consisting of a hydroxyl protective group, a hydrogen atom, and a capping group comprising an acetyl group, wherein a hydroxyl function at either the 2′ or 3′ position of the ring serves as the anchor group, and wherein the anchor group of only one universal linker subset optionally comprises a hydrogen atom.