Patent ID: 7592477

Claim:
A substituted methylene amide of Formula (I): as well as its geometrical isomers, its optically active forms as enantiomers, diastereomers and its racemate forms, as well as pharmaceutically acceptable salts thereof, wherein (I) R 1 is CH 2 —CH 2 -phenyl, CH 2 —CH 2 -napthyl, CH 2 -phenyl, or CH 2 -napthyl; R 2a and R 2b are each independently are H or (C 1 -C 12 )alkyl; Cy is a phenyl substituted by (1), (2) or (3): (1) an oxadiazole group; (2) 1 or 2 moieties selected from the group consisting of —NH—CO—R 3 , —SO 2 —NR 3 R 3′ and —CO—NR 3 R 3′ wherein R 3 and R 3′ are independently selected from H and (C 1 -C 15 )alkyl; or (3) B-R 4 wherein B is an ethynyl group and R 4 is a (C 1 -C 12 )alkyl phenyl; (II) R 2a and R 2b are each H, R 1 is —CH 2 -A with A being phenyl optionally substituted by cyano, halogen, methoxy, hydroxyl, phenoxy, —NO 2 , or trifluoromethyl, and Cy is phenyl or biphenyl substituted by —SO 2 R 3 , or —CO—NR 3 R 3′ where R 3′ is H and R 3 is (C 7 -C 12 )alkyl or (C 7 -C 15 )alkyl; or (III) R 2a and R 2b are each H, R 1 is selected from the group consisting of phenyl, benzyl, phenethyl, or 1-methylbenzyl which may be substituted by (C 1 -C 6 )alkyl or cycloalkyl, and Cy is phenyl or biphenyl substituted by —SO 2 R 3 , or —CO—NR 3 R 3 where R 3 is (C 7 -C 1 5 )alkyl.