Patent ID: 7528235

Claim:
An isolated antibody comprising: i) A light chain comprising: a) A first CDR having the sequence of SEQ ID NO: 2; b) A second CDR having a sequence selected from the group consisting of: i) SEQ ID NO: 3; and ii) SEQ ID NO: 3 containing a cysteine substitution wherein position 2 is substituted by a cysteine; c) A third CDR having the sequence of SEQ. ID. NO: 4; ii) A heavy chain comprising: a) A first CDR having the sequence of SEQ ID NO: 6; b) A second CDR having a sequence selected from the group consisting of: i) SEQ ID NO: 7; ii) SEQ ID NO: 7 containing a cysteine substitution wherein position 5 has been substituted by a cysteine; iii) SEQ ID NO: 7 containing a cysteine substitution wherein position 6 has been substituted by a cysteine; and iv) SEQ ID NO: 7 containing a cysteine substitution wherein position 7 has been substituted by a cysteine; c) A third CDR having the sequence SEQ ID NO: 8; wherein said antibody comprises at least one of said cysteine substitutions, and wherein said antibody binds substituted or unsubstituted 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″-tetraacetic acid (DOTA).