Patent ID: 7371734

Claim:
A method of stimulating an immune response in an animal or human comprising administering to the animal or the human a composition comprising a 3′-OH, 5′-OH polynucleotide sequence and a pharmaceutically acceptable carrier: wherein, a) the 3′-OH, 5′-OH polynucleotide sequence is six bases of which at least 50% are guanine and wherein a guanine is located at the 5′ end of the six bases; and, b) the composition stimulates the immune response in the animal or human, wherein the immune response comprises one or more responses selected from the group consisting of an increase in cell size, an increase in granularity, an increase in CD40, CD80, CD86 or MHC II cell surface expression, a decrease in OX-2 cell surface expression, a systemic immune response, a mucosal immune response and an increase in endocytosis.