Patent ID: 7776844

Claim:
A composition comprising an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject for treatment of a cosmetic condition or dermatological disorder; wherein the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof is N-(phosphonoalkyl)-proline or has the following formula: R 1 CH(NR 2 R 3 )(CH 2 ) m COR 4 wherein R 1 is H, and alkyl group having 1 to 19 carbon atoms, an aryl group having 6 to 19 carbon atoms or an aralkyl group having 7 to 19 carbon atoms; and R 1 can also carry —OH, —SH, —SCH 3 , —NH 2 , —NR 2 R 3 , —COR 4 , —NHCONH 2 , —NHC(═NR 2 )NH 2 , imidazole, pyrrolidine or other heterocyclic group; m is an integer from 0 to 5; R 2 is a phosphonoalkyl group having a formula (HO) 2 PO(CH 2 ) n —; R 3 is H or a phosphonoalkyl group having a formula (HO) 2 PO(CH 2 ) n —; n is an integer from 1 to 9; R 4 is —NH 2 or —OR 5 , R 5 is H, and alkyl group having 1 to 19 carbon atoms, an aryl group having 6 to 19 carbon atoms or an aralkyl group having 7 to 19 carbon atoms; and the H attached to any carbon atom can be substituted by I, F, Cl, Br, OH or an alkoxy group having 1 to 9 carbon atoms; and wherein the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof is in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form.