Patent ID: 8648067

Claim:
A compound of Formula I: wherein: R 1 is selected from pyrrolidin-1-yl, piperidin 1-yl, piperazin-1-yl, morpholin-4-yl, 1,3-dihydroisoindol-2-yl, hexahydro-pyrrolo[1,2-a]pyrazin-2-yl, or octahydro-pyrido[1,2-a]pyrazin-2-yl, wherein R 1 is optionally substituted with one to three R 20 groups; R 2 at each occurrence is independently F, Cl, Br, I, OR 21 , NR 23 R 24 , NO 2 , CN, CF 3 , C 1 -C 6 alkyl, C(═O)R 25 , CO 2 R 25 , or C(═O)NR 23 R 24 ; R 3 is H or C 1 -C 6 alkyl; R 4 is H or C 1 -C 6 alkyl; R 5 is wherein R 5 is para or meta to Y; X is O; Y is O; R 10 is H, C 1 -C 4 alkyl, cycloalkyl, or arylalkyl; R 11 is H, C 1 -C 6 alkyl, C(═O)R 25 , CO 2 R 25 ; A is selected from pyrrolidin-1-yl; piperidin-1-yl; morpholin-4-yl; piperazin-1-yl; thiomorpholin-4-yl; 2,3-dihyro-indol-1-yl; 1,3-dihydro-isoindol-2-yl; 3,4-dihydro-2H-quinolin-1-yl; 3,4-dihydro-1H-isoquinolin-2-yl; 2,3,4,5-tetrahydro-benzo[b]azepin-1-yl; indol-1-yl; and benzoimidazol-1-yl; wherein A can be optionally substituted with one to three R 20 groups; R 20 at each occurrence is independently, F, Cl, Br, I, OR 21 , OR 22 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 -C 6 alkyl optionally substituted with OR 21 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, 3-7 membered heterocycloalkyl, aryl, 5 or 6 membered heteroaryl, arylalkyl, (═O), C(═O)R 26 , CO 2 R 28 , OC(═O)R 25 , C(═O)NR 23 R 24 , NR 27 C(═O)R 25 , NR 27 C(═O)OR 25 , OC(═O)NR 23 R 24 , NR 27 C(═S)R 25 , or S(O) q R 25 , wherein said aryl groups are optionally substituted with one to three R 30 groups; R 21 at each occurrence is independently H, C 1 -C 6 alkyl, aryl, or arylalkyl; R 22 at each occurrence is independently the residue of an amino acid after the hydroxyl group of the carboxyl group is removed; R 23 and R 24 at each occurrence are each independently selected from H, C 1 -C 6 alkyl, and aryl, or R 23 and R 24 , together with the nitrogen atom to which they are attached, form a 3 to 7 membered heterocyclic ring optionally substituted with ═O; R 25 at each occurrence is independently C 1 -C 6 alkyl, aryl, or arylalkyl; R 26 at each occurrence is independently NR 23 R 24 , CF 3 , C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, 3-7 membered heterocycloalkyl, aryl, 5-10 membered heteroaryl, or arylalkyl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl groups are optionally substituted with one to three R 30 groups; R 27 at each occurrence is independently H or C 1 -C 6 alkyl; R 28 at each occurrence is independently C 1 -C 6 alkyl, aryl, or arylalkyl, wherein said groups are optionally substituted with one to three R 30 groups; R 30 at each occurrence is independently F, Cl, Br, I, OR 21 , OR 22 , NR 23 R 24 , NHOH, NO 2 , CN, CF 3 , C 1 -C 6 alkyl, aryl, or arylalkyl; n is 0, 1, 2, 3, or 4; m is 3; q is 0, 1, or 2; or a stereoisomer or a pharmaceutically acceptable salt thereof.