Patent ID: 7786264

Claim:
An antibody or fragment thereof comprising a heavy chain variable region and light chain variable region, wherein the sequences of the heavy chain variable region and the light chain variable region are (a) the amino acid sequences of SEQ ID NOS: 12 and 10, respectively, of monoclonal antibody 8C11, (b) the amino acid sequences of SEQ ID NOS: 8 and 6, respectively, of monoclonal antibody 13D8, or (c) the amino acid sequences of SEQ ID NOS: 16 and 14, respectively, of monoclonal antibody 8H3, and wherein the antibody or the fragment thereof binds to the native conformation of a polypeptide sequence encoded by hepatitis E virus (HEV) ORF2, but has decreased or no binding to the denatured polypeptide sequence encoded by hepatitis E virus (HEV) ORF2.