Patent ID: 8852636

Claim:
A pharmaceutical composition in unit dose form suitable for oral administration to a patient, comprising: (a) esomeprazole present in an amount effective to raise the gastric pH of said patient to at least 3.5 upon the administration of one or more of said unit dosage forms; (b) naproxen present in an amount effective to reduce or eliminate pain or inflammation in said patient upon administration of one or more of said unit dosage forms; and wherein: i) said unit dosage form is a tablet in which said naproxen is present in a core; ii) said tablet comprises a coating, wherein said coating surrounds said core and does not release said naproxen until the pH of the surrounding medium is 3.5 or higher; and iii) said esomeprazole is in one or more layers outside said core, wherein said one or more layers: A) do not include an naproxen; B) are not surrounded by an enteric coating; and C) upon ingestion of said tablet by a patient, release said esomeprazole into said patient's stomach.