Patent ID: 8722627

Claim:
A method for depigmenting, lightening and/or whitening the skin or epithelial appendages, the method comprising: providing a proteasome activating peptidic hydrolyzate comprising bioactive peptides, with a molecular weight of less than 6 kDa, comprising from 3 to 5 amino acids, each bioactive peptide comprising at least one aspartic acid, one cysteine residue, and an arginine residue and corresponding to one of the following sequences: (SEQ ID NO: 1) Arg-Asp-Cys-Arg-Arg; (SEQ ID NO: 2) Asn-Asp-Cys-Arg-Lys; (SEQ ID NO: 3) Asp-Cys-Arg-His; (SEQ ID NO: 4) Val-Asp-Cys-Arg; or (SEQ ID NO: 5) Asp-Cys-Arg; and topically applying an effective quantity of said peptidic hydrolyzate to the skin or epithelial appendages to be treated.