Patent ID: 8900133

Claim:
An imaging system for in vivo imaging, the imaging system comprising: (a) a video imaging system comprising: (i) a video imaging device adapted for passage within any portion of a gastrointestinal tract for imaging an area of interest from within an entire gastrointestinal tract, the video imaging device comprising an optical system for in vivo imaging adapted for detection of electromagnetic radiation, an electromagnetic radiation source, a transmitter for transmitting images from the optical system, and a power source; and (ii) a receiver for receiving images transmitted from the video imaging device; and (b) a biological probe comprising a fluorochrome with absorption and emission maximum between 600 and 1300 nm and one or more fluorochrome quencher molecules for targeting and attaching to an in vivo probe target; further wherein the video imaging device is swallowable and comprises an electromagnetic radiation filter for filtering electromagnetic radiation passing from and to the video imaging device, the filter comprising an excitation filter adapted to pass light between approximately 610 nm and 650 nm and an emission filter adapted to pass red and near infrared fluorescent (NIRF) light between approximately 680 nm and 720 nm; whereby the video imaging system is adapted to image the emission wavelength and visually identify diseased tissue, non-diseased tissue, or both diseased tissue and non-diseased tissue at the probe target within the transmitted images from the video imaging system.