Patent ID: 7074938

Claim:
A method for making a Soritin compound or having the following structural formula (A): or a Soritin composition comprising the Soritin compound which comprises reacting a compound of the structural formula (1): with a metallic base having the formula M {circle around (+)} B {circle around (âˆ’)} and then adding L-X, wherein L is a leaving group and X is, or is convertible to, â€”H, â€”OH, halogen, â€”COOH, â€”COOR, C 1 â€“C 8 alkyl, cycloalkyl, C 1 â€“C 8 alkoxyl, mesyl, tosyl, mesyloxy, tosyloxy, arylsulfonyl, arylsulfonyloxy, â€”OCOR, or NZ 1 Z 2 (wherein Z 1 and Z 2 can be the same or different) to give the Soritin compound or the Soritin composition, wherein R 1-10 are independently the same or different and selected from â€”H, â€”OH, halogen, â€”COOH, â€”COOR, C 1 â€“C 8 alkyl, cycloalkyl, C 1 â€“C 8 alkoxyl, mesyl, tosyl, mesyloxy, tosyloxy, arylsulfonyl, arylsulfonyloxy, â€”OCOR, or NZ 1 Z 2 (wherein Z 1 and Z 2 can be the same or different); Z 1 and Z 2 are independently the same or different and selected from â€”H, â€”OH, C 1 â€“C 8 alkyl, cycloalkyl, C 1 â€“C 8 alkoxyl, or â€”COR; R is C 1 â€“C 8 alkyl, cycloalkyl, or aryl; X is â€”H, â€”OH, halogen, â€”COOH, â€”COOR, C 1 â€“C 8 alkyl, cycloalkyl, C 1 â€“C 8 alkoxyl, mesyl, tosyl, mesyloxy, tosyloxy, arylsulfonyl, arylsulfonyloxy, â€”OCOR, or NZ 1 Z 2 (wherein Z 1 and Z 2 can be the same or different); M is a suitable metal ion; and B is a suitable base.