Patent ID: 8580825

Claim:
A compound of formula I: wherein: R 1 and R 2 are each independently hydrogen, C 1-7 alkyl or C 3-10 carbocycle, with the proviso that both R 1 and R 2 are not hydrogen; R 3 is a 5-11 membered heteroaryl ring containing one to three heteroatoms selected from nitrogen, oxygen and sulfur, wherein the heteroaryl ring is optionally independently substituted with one to three groups selected from C 1-5 alkyl, C 1-5 alkoxy, C 1-3 alkylhydroxy, amino, C 1-3 alkylamino, C 1-3 dialkylamino, oxo, —CN, halogen, and 5-6 membered heteroaryl optionally substituted with one to three methyl groups; R 4 is hydrogen, C 1-3 alkyl, halogen or nitrile; R 5 is C 1-6 alkyl, C 3-10 carbocycle, 5-11 membered heterocycle, aryl, 5-11 membered heteroaryl, —C(O)—R 6 or —NR 7 R 8 , wherein each R 5 is optionally independently substituted with one to three groups selected from R 9 , R 10 and R 11 ; R 6 is C 3-8 heterocycle or —NH-5-6 membered heterocycle, each optionally independently substituted with one to three groups selected from R 9 , R 10 and R 11 ; R 7 and R 8 are each independently hydrogen or C 1-6 alkyl, wherein the alkyl group is optionally substituted with —OH or C 1-3 alkoxy; R 9 , R 10 and R 11 are independently selected from (a) —H, (b) —OH, (c) halogen, (d) —CN, (e) —CF 3 , (f) C 1-6 alkyl optionally substituted with one to three —OH, —N(R 12 )(R 13 ), 3-6 membered heterocycle, C 1-6 alkoxy, halogen, CN, —CO 2 R 12 , —O—C 1-6 alkyl-O—C 1-3 alkyl, —C(O)N(R 12 )(R 13 ) or —S(O) n C 1-6 alkyl, (g) C 1-6 alkoxy, (h) —N(R 12 )(R 13 ), (i) —S(O)—C 1-6 alkyl, (j) —CO 2 R 12 , (k) —C(O)N(R 12 )(R 13 ), (l) —S(O) 2 N(R 12 )(R 13 ), (m) a 3-10 membered heterocyclic group optionally substituted with one to three C 1-6 alkyl groups or oxo, (n′) oxo, (o) —C(O)—C 1-3 alkyl; (p) C 1-6 alkenyl substituted optionally substituted with a —OH; R 12 and R 13 are each independently selected from —H, —C 1-6 alkyl, C(O)C 1-6 alkyl C 3-6 carbocycle and a 3-6 membered heterocyclic group, each of which is optionally independently substituted with one to three C 1-6 alkyl groups, halogen, —OH, C 1-6 alkoxy, —C(O)N(R 14 )(R 15 ), —S(O)—C 1-6 alkyl, CN, a 3-6 membered heterocyclic group, —OC 1-6 alkyl, CF 3 , or; R 12 and R 13 taken together with the nitrogen ring to which they are attached form a heterocyclyl ring optionally substituted with one to three —OH, CN, —OC 1-6 alkyl or oxo; R 14 and R 15 are each independently selected from —H and —C 1-6 alkyl; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.