Patent ID: 8410100

Claim:
A compound of formula 1 wherein: R 1 denotes isopropyl; R 2 denotes (i) halogen or a group selected from -Q-CO—NR 4 —C 6-14 -aryl-Z 1 —R 5 , -Q-CO—NR 4 —Z 1 —R 5 , -Q-NR 4 —CO—X—R 6 , -Q-NR 4 —SO 2 —X—R 7 ,-Q-NR 4 —SO 2 —Z 1 —R 7 , —Z 1 —SO 2 —R 16 , —SO 2 —Z 1 —R 16 , NO 2 , and CONR 4 R 8 ; or (ii) a group selected from the compounds of formula (III) or (IV), wherein X denotes a bond or O; Z 1 denotes a bond or C l-3 -alkylene; Q denotes a bond; R 4 denotes H; R 5 denotes (i) NR 4 R 8 ; (ii) an optionally substituted group selected from C 3-6 -cycloalkyl, C 3-8 -heterocycloalkyl and C 5-10 -heteroaryl; or (iii) an optionally substituted group selected from R 6 denotes C 1-5 -alkyl; R 7 denotes C 1-3 -alkyl or phenyl; R 8 denotes H; R 14 and R 17 are each independently H, C 3-6 -cycloalkyl, or ═O; R 15 and R 18 are each independently H or COOH; R 16 denotes H or C 1-3 -alkyl; B denotes C 3-8 -heterocycloalkyl; D denotes C 6-14 -aryl; or R 2 denotes a group of formula (VIII) or (IX) wherein A denotes a group selected from C 3-6 -cycloalkyl, C 6-14 -aryl, C 3-8 -heterocycloalkyl and C 5-10 -heteroaryl; W denotes N, C or O; Z 2 denotes a bond or C 1 -C 4 -alkylene; R 9 and R 10 each independently denote H, halogen, or a group selected from C 1-3 -alkyl, NR 4 R 8 , ═O, —C 1-2 -alkylene-phenyl, —NR 4 —C 1-2 -alkylene-phenyl, —COO—C 1-5 -alkyl, —CO-phenyl, —CO—C 1-5 -alkyl, —CO—Z 2 —C 3-6 -cycloalkyl, C 6-14 -aryl, C 5-10 -heteroaryl, C 3-6 -cycloalkyl and optionally substituted C 5-8 -heterocycloalkyl R 11 denotes H or C 1-3 -alkyl; R 12 denotes H, C 1-4 -alkyl, —Z 2 —NR 4 R 8 or —Z 2 —O—C 1-3 -alkyl; or R 11 and R 12 join to form an optionally substituted N-containing 5-to 6-membered heterocyclic ring; R 13 denotes H or C 1-3 -alkyl; or R 13 and R 12 join to form an N-containing 5- to 6-membered heterocyclic ring; R 3 denotes H, SO 2 Me, SO 2 NH 2 , —NHSO 2 Me, or CF 3 ; or a pharmaceutically acceptable salt, diastereomer, enantiomer, or racemate thereof.