Patent ID: 8003658

Claim:
A quinazoline derivative of formula (I) or a pharmaceutically acceptable salt thereof: wherein, R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkylamino, C 1-6 alkylthio, 2 ((N-methyl-(2′hydroxyethyl)amino)methyilvinyl, phenoxy, phenyl, dimethylaminoethoxymethyl, methoxyethoxymethyl, 4-methylpiperazinylmethyl, ethoxycarbonyl, benzamino, cyclopentenyl, 2-(4-methylpiperazinylmethylvinyl, methanesulfonylethylaminomethyl, methoxyethylaminomethyl, 2-(methanesulfonylethylaminomethyl)vinyl, or 5-membered heteroaryl having 1-2 heteroatoms selected from N, O, or S which are optionally substituted with X; R 2 is hydrogen, or C 1-6 alkyl; R 3 is hydrogen, C 1-6 alkyl or C C 1-6 dialkylamino C 1-6 alkyl; Y is —(CR 11 R 12 )—, phenyl or a 5-membered heteroaryl having 1 sulfur atom, R 11 and R 12 being each independently hydrogen, halogen, hydroxy, carboyC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkanoyl, C 1-6 alkoxycarbonyl, phenyl, or optionally fused to each other to form a 3 membered non-aromatic ring, or R 11 or R 12 may be fused to R 2 to form together with the carbon and nitrogen they are attached to a 4 to 8-membered non-aromatic ring, optionally comprising additional heteroatom S; R 4 is hydrogen, halogen, C 1-6 alkoxy, ethylsulfanyl, cyclopropylmethoxy, cyclopentyloxy or C 1-6 alkylamino optionally substituted with R 13 , R 13 being halogen, trifluoromethyl, C 1-6 alkoxy, 4-methylpiperidinylmethoxy, dimethylamino or a 6-membered heteroaryl having 1-2 heteroatoms selected from N and O; R 5 is hydrogen or C 1-3 alkyl; R 6 is phenyl, 1-phenyl-ethyl, 3-ethynyl-phenyl, 1-penta-2,4-dienyl-1H-indazol-5-yl, imidazole or a 9-membered heteroaryl having 1-2 nitrogen atoms, optionally substituted with R 15 , being hydrogen halogen, C 1-6 alkyl, or phenyl, benzyl, a 10-membered heteroaryl C 1-6 alkyl having 1 nitrogen atom, benzyloxy, a 6-membered heteroaryl C 1-6 alkoxy having 1 nitrogen atom, a 6-membered heteroaryloxy having a nitrogen atom, phenylcarbamoyl, optionally substituted with R 16 , wherein R 16 is halogen, nitro, C 1-6 alkyl, or C 1-6 alkoxy; n is an integer in the range of 1 to 4; p is 0 or 1; X is a halogen, nitro, cyano, trifluoromethyl, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 dialkylamino, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkanoyl, phenyl, or a 5- to 6-membered heteroaryl having 1-2 heteroatoms selected from N and O; wherein heteroaryl is a heteroaromatic or non-aromatic.