Patent ID: 7410984

Claim:
A compound of formula (I), a carboxylic acid ester or a pharmaceutically acceptable salt thereof: wherein A and B are independently aryl or heteroaryl; Q is C, CH or together with the group V or group D forms a 5-7 membered heterocyclic ring; D is hydrogen, C 1-6 alkyl or together with the group Q forms a 5-7 membered heterocyclic ring; R 1 , R 2 and R 3 are independently C 1-6 alkyl, halogen, C 1-6 alkoxy, hydroxy, cyano, CF 3 , nitro, C 1-6 alkylthio, amino, mono- or di-C 1-6 alkylamino, carboxy, C 1-6 alkanoyl, amido, mono- or di-C 1-6 alkylamido, NHCOR 9 or NHSO 2 R 9 in which R 9 is C 1-6 alkyl, C 3-7 cycloalkyl or phenyl (optionally substituted by up to three groups selected from C 1-6 alkyl, halogen, C 1-6 alkoxy, cyano, phenyl or CF 3 ) or is a group -E-(CH 2 ) 1-6 NR x R y in which E is a single bond or —OCH 2 — and R x and R y are independently hydrogen, C 1-6 alkyl or combine together to form a 5-7 membered heterocyclic ring; R 4 is hydrogen, C 1-6 alkyl, halogen or C 1-6 alkoxy; V is O, S, NH, N—C 1-6 alkyl, NNO 2 , NCN or together with the group Q forms a 5-7 membered heterocyclic ring; W, X, Y and Z are independently C, CH or CH 2 ; ------ represents a single or double bond; L is —(CH 2 ) q — or —(CH 2 ) q′ O— where q is 0, 1, 2 or 3 and q′ is 2 or 3; J is (i) a group —CR 5 ═CR 6 — where R 5 and R 6 are independently hydrogen or C 1-6 alkyl; or (ii) a group —CHR 7 —CHR 8 — where R 7 and R 8 are independently hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, heteroaryl, a group —NHCOR 9 — or —NHSO 2 R 9 — in which R 9 is as defined above or a group —(CH 2 ) 1-6 NR x R y — in which R x and R y are as defined above; or (iii) a single bond; or (iv) —CHR 6 — where R 6 is as defined above; or (v) a group —O—CHR 10 —, —NR 11 —CH 7 R 10 — or —CR 12 R 13 —CHR 10 — where R 10 and R 11 are independently hydrogen or C 1-6 alkyl and R 12 and R 13 are independently C 1-6 alkyl or R 12 and R 13 combine together to form a C 3-7 cycloalkyl or a 5-7 membered heterocyclic ring; m, n and p are independently 0, 1, 2 or 3; and t is 0, 1 or 2.