Patent ID: 8889642

Claim:
A method of treating a patient having a solid tumor expressing a mutated K-ras protein, comprising the step of administering to said patient a medicament comprising an RNAi agent, wherein said RNAi agent comprises a sense strand and an antisense strand, wherein said sense strand and said antisense strand have sequences set forth in A or B:: (SEQ ID No: 37) A. 5′-GUoUoGGAGCUGAUGGCGoUoAGdTdT and (SEQ ID No: 38) 5′-CUACGCCAUCAGCUCCAACdTdT; OR (SEQ ID No: 39) B. 5′-GUoUGGAGCoUGAoUGGCGoUAG and (SEQ ID No: 40) 5′-CoUACGCoCAUoCAGCUCoCAAC, respectively, wherein “o” preceding a residue denotes a 2′-O-Methyl modification of said residue, thereby treating the patient having the solid tumor expressing the mutated K-ras protein.