Patent ID: 6962975

Claim:
A standardized prion preparation, comprising: prions obtained from a plurality of transgenic mouse brains; and a carrier; wherein the preparation comprises prions (a) which infect and cause disease in an animal chosen from a human, a cow, and a sheep, (b) which are prions of a known strain, (c) the prions are present in a known number of infectious units, and further wherein the carrier is different from brain tissue of the animal chosen from a human, a cow and a sheep; wherein the prions are uniformly dispersed in the preparation and are produced in a transgenic mouse selected from the group consisting of: Tg(HuPrP)/Prnp 0/0 , Tg(ShePrP)/Prnp 0/0 , and Tg(BovPrP)[Prnp 0/0 .