Patent ID: 8741607

Claim:
A hepatitis C virus/GB virus-B (HCV/GBV-B) chimeric RNA comprising an RNA of hepatitis C virus and an RNA of GB virus-B, comprising: (A) an HCV 5′-side RNA comprising the 5′-untranslated region of hepatitis C virus; (B) a GBV-B RNA comprising an RNA encoding the E1 protein and the E2 protein of GB virus-B; and (C) an HCV 3′-side RNA comprising an RNA encoding the NS3 protein, the NS4A protein, the NS4B protein wherein leucine is substituted for the amino acid that corresponds to the amino acid at position 93 of SEQ ID NO: 108 and lysine is substituted for the amino acid that corresponds to the amino acid at position 255 of SEQ ID NO: 108, the NS5A protein and the NS5B protein of hepatitis C virus and the 3′-untranslated region of hepatitis C virus; said GBV-B RNA (B) being inserted between the HCV 5′-side RNA (A) and the HCV 3′-side RNA (C).