Patent ID: 7098308

Claim:
A compound of the formula: and pharmaceutically acceptable salts and solvates thereof, wherein, independently at each location: R 1 is selected from hydrogen and lower alkyl; R 2 is selected from hydrogen and lower alkyl; R 3 is lower alkyl; R 4 is selected from lower alkyl, aryl, and —CH 2 —C 5-7 carbocycle when R 5 is selected from H and methyl, or R 4 and R 5 together form a carbocycle of the partial formula —(CR a R b ) n — wherein R a and R b are independently selected from hydrogen and lower alkyl and n is selected from 2, 3, 4, 5 and 6; R 6 is selected from hydrogen and lower alkyl; R 7 is sec-butyl or iso-butyl; R 8 is selected from hydrogen and lower alkyl; R 9 is selected from R 10 is selected from R 11 is selected from hydrogen and lower alkyl; R 12 is selected from lower alkyl, halogen, and methoxy, and m is 0–5 where R 12 is independently selected at each occurrence; R 14 is selected from a direct bond, arylene (lower alkylene), lower alkylene and arylene; and R 15 is selected from hydrogen, lower alkyl and aryl.