Patent ID: 6872721

Claim:
A compound having a formula wherein R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, C 3-8 cycloalkyl, heteroC 3-8 cycloalkyl, C 3-8 cycloalkylC 1-3 alkyl, arylC 1-3 alkyl, and heteroarylC 1-3 alkyl; R 2 is selected from the group consisting of an optionally substituted monocyclic aromatic ring selected from the group consisting of benzene, thiophene, furan, and pyridine, and an optionally substituted bicyclic ring wherein the fused ring A is a 5- or 6-membered ring, saturated or partially or fully unsaturated, and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulfur, and nitrogen; R 3 is selected from the group consisting of hydrogen and C 1-6 alkyl, or R 1 and R 3 together represent a 3- or 4-membered alkyl or alkenyl chain component of a 5- or 6-membered ring; R 4 , independently, is selected from the group consisting of aryl, Het, C 3-8 cycloalkyl, YC 3-8 cycloalkyl (wherein Y is oxygen, sulfur, or NR a ), C(═O)R a , OC(═O)R a , C(═O)OR a , C 1-4 alkyleneNR a R b , C 1-4 alkyleneHet, C 1-4 alkyleneC(═O)OR a , C(═O)NR a SO 2 R c , C(═O)C 1-4 alkyleneHet, C(═O)NR a R b , C(═O)NR a R c , C(═O)NR a C 1-4 alkyleneOR b , C(═O)NR a C 1-4 alkyleneHet, OR a , OC 1-4 alkyleneC(═O)OR a , OC 2-4 alkyleneNR a R b , OC 1-4 alkyleneHet, OC 2-4 alkyleneOR a , OC 1-4 alkyleneNR a C(═O)OR b , NR a R b , NR a C 1-4 alkyleneNR a R b , NR a C(═O)R b , NR a C(═O)NR a R b , N(SO 2 C 1-4 alkyl) 2 , NR a (SO 2 C 1-4 alkyl), nitro (NO 2 ), trifluoromethyl, trifluoromethoxy, cyano (CN), SO 2 NR a R b , SO 2 R a , SOR a , SR a , and OSO 2 CF 3 ; R 5 is selected from the group consisting of hydrogen, halogen, and C 1-6 alkyl; or R 4 and R 5 are taken together with the carbon atoms to which they are attached to form a 5-, 6-, or 7-membered ring, saturated or partially or fully unsaturated, optionally substituted and optionally containing one or two heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen; R a is selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, aryl, arylC 1-3 -alkyl, C 1-3 alkylenearyl, and Het; R b is selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, arylC 1-3 alkyl, C 1-3 alkylenearyl, and Het; R c is phenyl or C 4-6 cycloalkyl, either optionally substituted with one or more substituent selected from the group consisting of halo, C(═O)OR a , and OR a ; Het is a 5- or 6-membered heterocyclic group, saturated or partially or fully unsaturated, containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, and optionally substituted with C 1-4 alkyl or C(═O)OR b ; q is 1, 2, or 3; and pharmaceutically acceptable salts and hydrates thereof.