Patent ID: 8142821

Claim:
An aqueous xanthohumol and isoxanthohumol composition extracted from hops formulated for topical administration which is prepared by a process comprising: providing a first solution containing hops and a first solvent, wherein the hops include 0.4-20% by weight xanthohumol and the first solvent includes up to 90% by volume water and at least 3% by volume a water miscible solvent; adjusting the salt concentration of the first solution from 0.05 M to 5.0 M and the pH value of the first solution from 10.5 to 12.0 to produce a first precipitate; removing the first precipitate to obtain a second solution; adjusting the pH of the second solution from 7 to 8 to produce a second precipitate; and collecting the second precipitate, wherein the second precipitate contains the aqueous xanthohumol and isoxanthohumol composition extracted from hops wherein the composition contains 40-95% by weight xanthohumol and wherein the composition comprises an isoxanthohumol/xanthohumol ratio that is 0.01-0.5.