Patent ID: 8759531

Claim:
A method for preparing the compound of the following formula, wherein, the method includes: (a) in an inert solvent and in the presence a base, reacting compound B2 with compound V to form said compound; wherein, X is Cl, Br, I, or OSO 2 CF 3 ; or, the method includes: (b) in an inert solvent, reacting compound B′ with CD 3 NH 2 or CD 3 NH 2 .HCl to form said compound; wherein, R is H, straight-chain or branched chain C1-C8 alkyl, or aryl; or, the method includes: (c) in an inert solvent, reacting 3-fluoro-4-aminophenol with compound V to form compound B1; in an inert solvent, reacting compound B1 with compound W to form compound M; and in an inert solvent, reacting compound M with 4-chloro-3-trifluoromethylaniline to form said compound; wherein, R is hydrogen, methyl, nitro and chlorine; said inert solvent is selected from chloroform, dichloromethane, tetrahydrofuran, 1,4-dioxane, toluene, pyridine, DMF, DMSO, or the mixed solvent thereof; said base is selected from pyridine, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, triethylamine, N,N-diethyl isopropyl amine, N,N-dimethylamine pyridine, N-methylmorphine, or the combination thereof; or, the method includes: (d) in an inert solvent, reacting 4-chloro-3-trifluoromethylaniline with compound W to form compound B; and in an inert solvent, reacting compound B1 with compound B to form said compound; wherein, R is hydrogen, methyl, nitro and chlorine; said inert solvent is selected from chloroform, dichloromethane, tetrahydrofuran, 1,4-dioxane, toluene, pyridine, DMF, DMSO, or the mixed solvent thereof; said base is selected from pyridine, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, triethylamine, N,N-diethyl isopropyl amine, N,N-dimethylamine pyridine, N-methylmorphine, or the combination thereof.