Patent ID: 6894189

Claim:
A method of preparing a compound of Formula 1: or a pharmaceutically acceptable salt, solvate, clatbrate, hydrate, or prodrug thereof, wherein R 1 is substituted or unsubstituted alkyl; and each R 2 and R 3 is independently hydrogen or substituted or unsubstituted alkyl, which comprises contacting a compound of Formula 2: wherein X is independently a polymer bound alkyl, aryl or heteroalkyl; substituted or unsubstituted alkyl; substituted or unsubstituted aralkyl; substituted or unsubstituted heteroalkyl; substituted or unsubstituted aryl; substituted or unsubstituted ether; substituted or unsubstituted ester; substituted or unsubstituted ketone; substituted or unsubstituted phosphonate; substituted or unsubstituted phosphonic acid ester; substituted or unsubstituted phosphinoyl; substituted or unsubstituted sulfide; substituted or unsubstituted sulfone; substituted or unsubstituted sulfinyl imine; substituted or unsubstituted heterocycle; or NR 4 R 5 , wherein R 4 and R 5 together with the nitrogen atom to which they are attached form a heterocycle or each of R 4 and R 5 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted ether, substituted or unsubstituted sulfide, or substituted or unsubstituted heterocycle; with a reagent capable of cleaving a nitrogen-sulfur bond under conditions suitable for the formation of the compound of Formula 1.