Patent ID: 8420783

Claim:
A multispecific antibody that reacts specifically with at least two different targets, wherein said targets are (A) a proinflammatory effector of the innate immune system which is a proinflammatory effector cytokine or a proinflammatory effector chemokine, wherein said antibody acts by neutralizing said (A) target, and (B) a target specifically associated with an infectious disease, acute respiratory distress syndrome, septicemia or septic shock, graft versus host disease or transplant rejection, atherosclerosis, asthma, granulomatous disease, a neuropathy, cachexia, a coagulopathy, acne, giant cell arteritis, or myocardial ischemia, wherein said latter target is not (A), wherein CD74 is excluded as a target of said multispecific antibody, said multispecific antibody comprising a therapeutic agent.