Patent ID: 7129234

Claim:
A compound of general formula (I), or pharmaceutically acceptable salts thereof; wherein; L and U, which may be the same or different, are —N—, —N + (—O − )— or —C(H)—; M and Q, which may be the same or different, are —N—, —N + (—O − )— or —C(R 4 )—; wherein ring A contains 1 nitrogen atoms; R 1 and R 2 , which may be the same or different, are hydrogen, C 1-6 alkyl, (CH 2 ) m (C 3-6 cycloalkyl) wherein m=0, 1, 2 or 3, or R 1 and R 2 together with the nitrogen to which they are attached form an azetidine ring; W, Y and Z, which may be the same or different, are hydrogen, halogen, C 1-6 alkyl, CF 3 , OCF 3 , C 1-4 alkylthio or C 1-4 alkoxy; or Y and Z are linked so that, together with the interconnecting atoms, Y and Z form a fused 5 to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic, and wherein when Y and Z form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; and wherein W, Y and Z are not all hydrogen; and each R 4 is independently: A-X, wherein A=—(CH 2 ) p — where p is 0, 1 or 2; X is hydrogen, CONR 6 R 7 , SO 2 NR 6 R 7 , SO 2 NHC(═O)R 6 , hydroxy, C 1-4 alkoxy, NR 8 SO 2 R 9 , NO 2 , NR 6 R 11 , CN, CO 2 R 10 , SR 10 , S(O)R 9 or SO 2 R 10 ; R 6 , R 7 , R 8 and R 10 which may be the same or different, are hydrogen or C 1-6 alkyl optionally substituted independently by one or more R 12 ; R 9 is C 1-6 alkyl optionally substituted independently by one or more R 12 ; R 11 is hydrogen, C 1-6 alkyl optionally substituted independently by one or more R 12 , C(O)R 6 , CO 2 R 9 , C(O)NHR 6 or SO 2 NR 6 R 7 ; R 12 is fluoro, hydroxy, CO 2 H, C 3-6 cycloalkyl, NH 2 , CONH 2 , C 1-6 alkoxy, C 1-6 alkoxycarbonyl or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally substituted independently by one or more R 13 ; or R 6 and R 7 , together with the nitrogen to which they are attached, form a 4-, 5- or 6-membered heterocyclic ring optionally substituted independently by one or more R 13 ; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R 13 ; wherein R 13 is hydroxy, C 1 –C 4 alkoxy, fluoro, C 1 –C 6 alkyl, haloalkyl, haloalkoxy, —NH 2 , —NH(C 1 –C 6 alkyl) or —N(C 1 –C 6 alkyl) 2 .