Patent ID: 8143397

Claim:
A process for the preparation of Voriconazole which has an X-ray crystal diffraction pattern selected from the group consisting of: (a) a pattern with peaks at about 6.9°, 13.8°, 14.8°, 18.2°, 19.7°, 24.5°, 27.8° and 35.0°; and (b) a pattern with peaks at about 12.6°, 15.9°, 16.5°, 17.4°, 21.2°, 22.5°, 26.1°, 28.2° and 29.8°; by treating Voriconazole (1R)-(−)-10-camphorsulfonate with a non-chlorinated organic solvent and an aqueous alkaline solution, wherein the Voriconazole (1R)-(−)-10-camphorsulfonate is obtained by a process which comprises: (a) dehalogenation of where X is a halogen, under catalytic transfer hydrogenation by using a catalyst in a solvent, wherein the obtained racemic Voriconazole is not isolated, (b) reacting the racemic Voriconazole with (1R)-(−)-10-camphorsulfonic acid in methanol, (c) optionally drying the obtained Voriconazole (1R)-(−)-10-camphorsulfonate.