Patent ID: 7449583

Claim:
Process for synthesizing loratadine, which consists in a) reacting 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-3-methylpyridine of formula I with 3-chlorobenzyl chloride, in the presence of a strong base, to give 3-[2-(3-chlorophenyl) ethyl]-2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)pyridine of formula II b) reacting compound II with the Grignard reagent of 4-chloro-N-methylpiperidine, in an inert solvent, to give [3-[2-(3-chlorophenyl)ethyl]-2-[4,4-dimethyl-2-(1-methyl-piperidin-4-yl)-oxazolidine-2-yl]pyridine of formula III, and c) hydrolyzing compound III to give the intermediate of formula b) which is converted by known methods into loratadine.