Patent ID: 8476437

Claim:
A process for the preparation of compound of formula (I) or its salts comprising, a) reacting trifluorophenylacetic acid (II) or its acid chloride with Meldrum's acid and 3-trifluoromethyl 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine.HCl of formula (III) in presence of a suitable base and suitable acid, which is further converted to the compound of a formula (IV) by reacting with suitable alkali and alkali earth metals in suitable solvent b) reacting the compound of formula (IV) with suitable ammonia source or with a suitable organic amine in a suitable solvent and optionally in the presence of a suitable acid to obtain the compound of formula (V) (c) reducing the compound of formula (V) by using suitable borane containing reducing agent optionally in the presence of an acid in a suitable solvents to obtain racemic compound of formula (VI) d) resolution of the compound formula (VI) by suitable chiral resolving agents in suitable solvents to obtain the diastereomeric salt of compound of formula (I) e) optionally, deprotecting the compound of formula (VI) (Wherein R≠H) prior to resolution; f) converting the diastereomeric salt of compound of formula (I), with suitable base in presence of suitable solvents to obtain compound of formula (I); g) optionally preparing a salt of formula (I), as formula (Ib), having at least 70% chiral purity, by reacting the compound of formula (I) with a suitable acid(s) in a suitable solvent(s), with the salt further converted to the compound of formula (Ia), having at least 90% chiral purity, by suitable chiral enrichment