Patent ID: 8492352

Claim:
A synthetic polysaccharide with antithrombotic activity, corresponding to the formula: wherein: the wavy line denotes a bond located either below or above the plane of the pyranose ring, and the formula: denotes a polysaccharide containing n identical or different monosaccharide units, said polysaccharide being bonded via its anomeric carbon to Pe, and the formula: is a diagrammatic representation of a monosaccharide unit with a pyranose structure, chosen from hexoses, pentoses and the corresponding deoxy sugars, this unit being bonded via its anomeric carbon to another monosaccharide unit, and the hydroxyl groups of this unit being substituted with groups R 1 , which may be identical or different, R 1 being as defined below, and Pe represents a pentasaccharide having the structure: wherein h is equal to 1 or 2, and n is an integer and can take any value from 0 to 25, and R 1 represents an —NH—CO—(CH 2 ) 5 —NH 2 group, a (C 1 -C 6 )alkoxy group or an —OSO 3 − group; and R 2 represents an —NH—CO—(CH 2 ) 5 —NH 2 group, a (C 1 -C 6 )alkoxy group or an —OSO 3 − group; and R 3 represents an —NH—CO—(CH 2 ) 5 —NH 2 group or a (C 1 -C 6 )alkoxy group; and R 4 represents an —NH—CO(CH 2 ) 5 —NH 2 group, a (C 1 -C 6 )alkoxy group or an —OSO 3 − group or else R 4 constitutes an —O—CH 2 bridge, the —CH 2 — group being bonded to the carbon atom bearing the carboxylic function on the same ring; and wherein at least one of the substituents R 1 , R 2 , R 3 or R 4 represents an —NH—CO—(CH 2 ) 5 —NH 2 group; and wherein W represents an oxygen atom or a methylene group, and pharmaceutically acceptable salts thereof.