Patent ID: 6951656

Claim:
A method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process comprising the steps of: (i) dissolving the organic compound in the water-miscible first solvent; (ii) mixing into the first solvent and/or the second solvent a first surface modifier selected from the group consisting of anionic surfactants, nonionic surfactants and surface active biological modifiers; (iii) mixing the solution with the second solvent to define a pre-suspension; and (iv) adding energy to the pre-suspension by a method selected form the group consisting of homogenization, counter-current flow homogenization, and microfluidization to form crystalline particles having an average effective particle size of less than about 2 μm.