Patent ID: 8455525

Claim:
A compound according to formula I: wherein: R x is CN, Cl, Br, NO 2 or R x1 ; R y is CH 3 , CF 3 or halogen; R z is H, C 1-3 alkyl, C 1-3 haloalkyl, NO 2 , NH 2 , OMe, halogen or OH; or R y and R z together form R x1 is a 5 member heteroaryl, said heteroaryl selected from: R′ is hydrogen, C 1 -C 2 alkyl, CF 3 , or halogen; or R x and R y together with the phenyl group to which they are attached form a 5 member aromatic ring selected from: wherein each R″ is independently hydrogen, CF 3 , or C 1 -C 2 alkyl; A is a five member heteroaryl selected from each R a is independently selected from C 1-4 alkyl, wherein said alkyl is optionally substituted with 1-2 substituents independently selected from CN, OH and 5 member heteroaryl; 5-member heteroaryl, CN, —N(R b )C(O)OC 1-6 alkyl, —N(R b )C(O)OPhenyl, wherein said phenyl is optionally substituted with from 1-3 substituents independently selected from CN, halogen, OH, C 1-3 alkyl, and OC 1-3 alkyl; —N(R b )C(O)C 1-6 alkyl, —N(R b )C(O)Phenyl, wherein said phenyl is optionally substituted with from 1-3 substituents selected from CN, halogen, OH, C 1-3 alkyl, and OC 1-3 alkyl; NR b R b′ , C 1-4 haloalkyl, halogen, OH, OC 1-3 alkyl, OC 1-3 haloalkyl, OSO 2 -phenyl, wherein said phenyl is optionally substituted with halogen, C 1-3 alkyl or C 1-3 haloalkyl; S(O) 0-2 -phenyl, and S(O) 0-2 C 1-3 alkyl; R b and R b′ are each independently selected from hydrogen, C 1-3 alkyl and C 1-3 haloalkyl; n is 0, 1, 2, or 3; R 1 and R 2 are each independently selected from hydrogen, C 1-3 alkyl, C 1-3 haloalkyl or phenyl; R 3 is hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 2-4 hydroxylalkyl, benzyl, wherein the phenyl group of said benzyl is optionally substituted with from 1-3 substituents selected from halogen, C 1-3 alkyl, S(O) 0-2 C 1-3 alkyl, S(O) 0-2 -phenyl, O—C 1-6 alkyl, and OCF 3 ; C(O)—C 1-6 alkyl and C(O)Phenyl; R 4 is H, C 1-4 alkyl or C 1-4 haloalkyl; or pharmaceutically acceptable salts thereof.