Patent ID: 8828932

Claim:
A pharmaceutical composition comprising a polypeptide comprising: a first domain comprising a portion of soluble CD4, wherein said portion of soluble CD4 comprises the D1D2 domain of soluble CD4; a second domain comprising a human immunodeficiency virus (HIV) gp41 functional domain-binding sequence selected from the group consisting of N-terminal heptad repeat (NHR)-binding peptides, C-terminal heptad repeat (CHR)-binding peptides and fusion peptide (FP)-binding peptides; and a flexible linker linking the amino acid sequences of said first domain and said second domain, wherein said linker comprises the amino acid sequence (GGGGS) n , wherein n is an integer between 2 and 8; wherein the polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:37-62.