Patent ID: 7037916

Claim:
A compound of formula wherein Q is chosen from hydroxyalkyl, unsubstituted and substituted aryl, unsubstituted and substituted heterocyclyl, R 12 OC(O)—(CH 2 ) p —, R 11 R 12 NC(O)—, R 11 C(O)NR 12 —, R 11 C(NH)NR 12 —, R 12 C(O)—, R 11 OC(O)NR 12 —, R 11 NHC(O)NR 12 — and HetB-Y-HetA-; U is chosen from hydrogen, halogen, (C 1 –C 20 )hydrocarbon and substituted (C 1 –C 20 )alkyl; V a is chosen from —R 3 , —OR 3 and —SR 3 ; HetA is aryl or heterocyclyl; Y is —CH 2 —, a direct bond or —O—; HetB is aryl or heterocyclyl, with the proviso that when HetA is imidazole, Y is a direct bond and V a is hydrogen, (C 1 –C 6 )alkyl or (C 1 –C 6 )alkoxy, HetB cannot be benzofuran, indole, benzothiophene or substituted benzofuran, indole or benzothiophene; R 1 is chosen from alkyl, cycloalkyl, aryl, heterocyclyl, —(C 1 –C 4 )alkylaryl, and —(C 1 –C 4 )-alkylheterocyclyl; R 2 is H or (C 1 –C 4 )alkyl; R 3 is chosen from (C 1 –C 20 )hydrocarbon, substituted (C 1 –C 20 )alkyl and [(C 1 –C 20 )alkyl]R 7 ; R 4 is A 1 or A 2 ; A 1 is chosen from —C(O)NR 5 R 6 , —C(O)OR 5 , and A 2 is chosen from R 8 C(O)NH—, R 5 R 6 N—, and R 5 O—, with the proviso that, when m and n are both zero, R 4 cannot be A 2 ; is a 5-, 6- or 7-membered nitrogen heterocycle attached to the carbonyl of A 1 via nitrogen; R 5 is chosen from aryl, heterocyclyl, -(heterocyclyl)-R 10 , —CH 2 C(O)NHalkyl, —[(C 1 –C 10 )hydrocarbon]-R 10 and -[(monosubstituted (C 1 –C 10 )alkyl]-R 10 , with the proviso that when A 1 is —C(O)NR 5 R 6 and a nitrogen occurs in R 5 , the nitrogen in R 5 must be more than two carbons removed from the nitrogen in —C(O)NR 5 R 6 ; R 6 is H or C 1 –C 6 -alkyl; or R 1 and R 6 taken together form a 5-, 6- or 7-membered nitrogen heterocycle; R 7 is chosen from aryl, substituted aryl, aryloxy, substituted aryloxy, arylthio, substituted arylthio, heteroaryloxy, substituted heteroaryloxy, heteroarylthio, substituted heteroarylthio, heterocyclyl, and substituted heterocyclyl; R 8 is chosen from alkyl, aryl, substituted alkyl, —(C 1 –C 4 )alkylaryl, and —(C 1 –C 4 )alkylheterocyclyl; R 9 is chosen from H, C 1 –C 6 -alkyl and aryl; R 10 is chosen from H, F, alkyl, fluoroalkyl, —O-alkyl, —O-(substituted)alkyl,oxaalkyl, —S-alkyl, —SO-alkyl, —SO 2 -alkyl, —CH 2 O-alkyl, —CH 2 S-alkyl, —CH 2 SO-alkyl, —CH 2 SO 2 -alkyl, —N(C 1 –C 6 )alkyl-O—(C 1 –C 6 )alkyl, aryl, and heterocyclyl; R 11 is chosen from H, C 1 –C 6 -alkyl, cycloalkyl, aryl and substituted-C 1 –C 6 -alkyl; R 12 is H or C 1 –C 6 -alkyl; m is zero or one; n is zero or one, and p is zero or 1–6.