Patent ID: 6841688

Claim:
A method of preparing an optically pure (R)-tetrahydrofuranyl ketone, which comprises the following steps of: dehydrating (R)-2-tetrahydrofuran amide, represented by the following chemical formula 1a, in the presence of a dehydrating agent and an amine base at 50 to 100° C. for 2 to 6 hours to obtain (R)-2-tetrahydrofuran nitrile represented by the following chemical formula 2a; nucelophilic addition-reacting (R)-2-tetrahydrofuran nitrile with a nucleophile in an organic solvent at the temperature range of −80 to 100° C. for 10 minutes to 4 hours, followed by hydrolyzing by use of aqueous acidic solution to produce (R)-tetrahydrofuranyl ketone represented by the following chemical formula 3a; and recovering the resulting product obtained from the previous step: wherein, R is a straight-chained or branched, saturated or unsaturated aliphatic alkyl group having 1-30 carbon atoms; a saturated or unsaturated, substituted or unsubstituted cyclic alkyl group having 3-30 carbon atoms; or a substituted or unsubstituted aryl group having 6-30 carbon atoms.