Patent ID: 7074805

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein - - - is absent or is a single bond; X 1 is CR 1 ; X 2 is selected from the group consisting of N and CR 2 ; X 3 is selected from the group consisting of N and CR 3 ; X 4 is CR 4 ; X 5 is selected from the group consisting of N and C; provided that only one of X 2 , and X 3 is N; Z 1 is O; Z 2 is a bond or selected from the group consisting of NH and O; L is selected from the group consisting of alkenylene, alkylene, cycloalkylene, â€”(CH 2 ) m O(CH 2 ) n â€”, and N(R Y ), wherein the left end of â€”(CH 2 ) m O(CH 2 ) n â€” is attached to Z 2 and the right end is attached to R 9 ; m and n are each independently 1-6; R Y is selected from the group consisting of hydrogen and alkyl; R 1 , R 3 , R 5 , R 6 , and R 7 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, â€”NR A S(O) 2 R B , â€”S(O) 2 R B , â€”NZ A Z B , (NZ A Z B )alkyl, (NZ A Z B )carbonylalkyl and (NZ A Z B )sulfonyl, wherein Z A and Z B are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, and arylalkyl; R 2 and R 4 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, â€”NR A S(O) 2 R B , â€”S(O) 2 OR A , â€”S(O) 2 R B , â€”NZ A Z B , (NZ A Z B )alkyl, (NZ A Z B )alkylcarbonyl, (NZ A Z B )carbonyl, (NZ A Z B )carbonylalkyl, and (NZ A Z B )sulfonyl; R A is selected from the group consisting of hydrogen and alkyl; R B is selected from the group consisting of alkyl, aryl, and arylalkyl; R 8a is selected from the group consisting of hydrogen and alkyl; R 8b is absent when X 5 is N or R 8b is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonylalkyl, alkyl, alkylcarbonyloxy, alkylsulfonyloxy, halogen, and hydroxy when X 5 is C; and R 9 is selected from the group consisting of hydrogen, aryl, cycloalkyl, and heterocycle.