Patent ID: 8609685

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: n is 1 or 2 m is an integer from 0 to 3 A is NR 1 R 2 , or N + R 1 R 2 R 3 R 1 , R 2 and R 3 are, each independently, hydrogen; C 1-8 alkyl or heteroalkyl; C 2-8 alkenyl or heteroalkenyl; C 2-8 alkynyl or heteroalkynyl; optionally substituted aryl, alkylaryl, heteroaryl, alkylheteroaryl; or any two of R 1 , R 2 , and R 3 taken together with the nitrogen to which they are attached form a heterocyclic group, optionally substituted by one or more oxo, thioxo, and optionally comprising a heteroatom selected from O, S, and N, provided that the heteroatom is separated from the nitrogen atom by a least two carbon atoms; R 4 and R 5 are each independently hydrogen; optionally substituted C 1-4 alkyl or heteroalkyl; C 2-5 alkenyl or heteroalkenyl; C 2-5 alkynyl or heteroalkynyl; optionally substituted aryl, alkylaryl, heteroaryl, or alkylheteroaryl; B is C 1-4 alkyl; C 2-4 alkenyl; C 2-4 alkynyl; aryl, alkylaryl, heteroaryl or alkylheteroaryl; all optionally substituted by one or more halogen; Y is selected among OR 6 , NHR 6 , NR 6 R 7 , NH—S(O) 2 —R 6 , N + (R 6 ) 3 , SR 6 , N 3 , C(O)OR 6 , CN, C(S)OR 6 , C(S)NHR 6 , C(NH)NHR 6 , NH(CNH)NHR 6 , NH(CS)NHR 6 , NH(CO)NHR 6 and or Y is a group of formula (II), (III) or (IV): wherein * indicates the atom is linked to the formula (I) moiety; wherein A, B, n and m are, each independently, as previously defined; and each z is independently O, NH or S; each w is independently an integer from 1 to 4; R 6 is hydrogen; optionally substituted C 1-8 alkyl; C 2-8 alkenyl; C 2-8 alkynyl; optionally substituted aryl; heteroaryl; R 7 is optionally substituted C 1-8 alkyl; C 2-8 alkenyl; or C 2-8 alkynyl; optionally substituted aryl or heteroaryl, R 8 and R 9 are each independently hydrogen; optionally substituted C 1-18 alkyl; C 2-18 alkenyl; C 2-18 alkynyl; optionally substituted aryl; heteroaryl.