Patent ID: 7928132

Claim:
A method for the amelioration of episodes of acute or chronic ulcerative colitis in a mammal comprising administering to the mammal a pharmaceutical composition comprising an active compound having the formula selected from the group consisting of: wherein Y is selected from the group consisting of H, C 1 -C 4 alkyl, C 1 -C 4 substituted alkyl, —NO 2 , and the phenyl moiety: and wherein no more than one Y group in said active compound is the phenyl moiety; R 1 is selected from the group consisting of H, —OH, C 1 -C 4 alkyl, and C 1 -C 4 substituted alkyl; R 2 is selected from the group consisting of H, C 1 -C 4 alkyl and C 1 -C 4 substituted alkyl; R 4 is selected from the group consisting of H, C 1 -C 4 alkyl, and C 1 -C 4 substituted alkyl; X is selected from the group consisting of S and O; Z is selected from the group consisting of —SR 3 and —OR 3 ; and R 3 is selected from the group consisting of H, C 1 -C 4 alkyl, C 1 -C 4 substituted alkyl, and —CH 2 Ph; and wherein at least two of the R 2 and R 3 groups in said compound are C 1 -C 4 alkyl when neither Y is the phenyl moiety, in combination with at least one additional compound selected from the group consisting of salicylates, corticosteroids, immunosuppressants, antibiotics, anti adhesion molecules, and a vitamin D compound, wherein each substituted C 1 -C 4 alkyl is a C 1 -C 4 alkyl substituted with one or more of: hydroxyl groups, alkyoxyl groups, carboxyl groups, halogens, nitro groups, amino groups or acylamino groups.