Patent ID: 7385082

Claim:
A method for preparing 1,3-diphenylprop-2-en-1-one derivatives substituted by a carboxyalkyloxy or carboxyalkylthio group of the following formula: in which: X1 represents a halogen or a -R1 group or a group corresponding to the following formula: -G1-R1; X2 represents a hydrogen atom or a thionitroso group or an alkyloxy group or an alkylcarbonyloxy group or an alkylthio group or an alkylcarbonylthio group; X3 represents a -R3 group or a group corresponding to the following formula: -G3-R3; X4 represents a halogen or a thionitroso group or a -R4 group or a group corresponding to the following formula: -G4-R4; X5 represents a -R5 group or a group corresponding to the following formula: -G5-R5; R1, R3, R4, R5, which are the same or different, represent a hydrogen atom or an alkyl group substituted or not by a carboxylic acid function; G1, G3, G4, G5, which are the same or different, represent an oxygen or sulfur atom; with one of the groups X1, X3, X4 or X5 corresponding to the formula -G-R, in which R is an alkyl group containing a carboxylic acid function, weherein said method comprises the following steps: (i) contacting at least one 1,3-diphenylprop-2-en-1-one derivative substituted on one of the two phenyl groups by a hydroxyl or thiol group with at least one halogenated compound represented by general formula (II): in which Y represents a halogen atom, R is a C1-C24 alkyl chain and R′ is an acid-labile protective group of carboxylic acid; (ii) acid hydrolysis of the ester obtained in step (i).