Patent ID: 7906627

Claim:
A chimeric receptor polypeptide which possesses all of the discrete regions or domains which are present in an endogenous T1R polypeptide and which comprises the entire extracellular domain of a first T1R which is selected from the group consisting of human T1R1 and human T1R2 or a variant thereof possessing at least 90% sequence identity therewith and the entirety of the transmembrane domains of a second (different) human T1R relative to the first T1R which is also selected from the group consisting of human T1R1 and T1R2 or a variant thereof possessing at least 90% sequence identity therewith, wherein said chimeric receptor polypeptide alone or in association with another T1R polypeptide responds to umami or sweet taste ligands and wherein all of the remaining residues of said chimeric receptor polypeptide as a whole possess at least 90% sequence identity to all of the corresponding residues of an endogenous (unmodified) T1R polypeptide.