Patent ID: 7452910

Claim:
A method of inhibiting multidrug-resistant tumor growth or inhibiting metastasis, in a patient comprising administering to said patient an amount of one or more N-substituted indol-3-glyoxylamides of formula I or a physiologically tolerable acid addition salt thereof effective for inhibiting multidrug-resistant tumor growth or inhibiting metastasis wherein the radicals R, R 1 , R 2 , R 3 , R 4 , and Z have the following meanings: R is hydrogen; R 1 is a pyridine structure of formula II where the pyridine structure is bonded at either the 2, 3, or 4 position of the ring and is optionally substituted by substituents R 5 or R 6 or both R 5 and R 6 , wherein R 5 and R 6 can be identical or different and are independently selected from (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkoxy, nitro, amino, hydroxyl, halogen, trifluoromethyl, ethoxycarbonylamino radical and a carboxyalkyloxy group in which the alkyl group has 1-4 C atoms; R 2 is a (C 1 -C 6 )-alkyl group, where the alkyl group is monosubstituted by phenyl, which is optionally substituted by one or more substituents selected from halogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, a carboxyl group, a carboxyl group esterified with a C 1 -C 6 -alkanol, a trifluoromethyl group, a hydroxyl group, a methoxy group, an ethoxy group a benzyloxy group, a 2-quinolyl group or a 2-, 3- or 4-pyridyl group, wherein the 2-quinolyl and 2-, 3-, or 4-pyridyl groups can both in each case be mono- or polysubstituted by halogen, (C 1 -C 4 )-alkyl group or (C 1 -C 4 )-alkoxy; R 3 and R 4 can be identical or different and are independently selected from hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkanoyl, (C 1 -C 6 )-alkoxy, halogen, benzyloxy, a nitro group, an amino group, a (C 1 -C 4 )-mono or dialkyl-substituted amino group, a (C 1 -C 6 ) alkoxycarbonylamino group, and a (C 1 -C 6 )-alkoxycarbonylamino-(C 1 -C 6 )-alkyl group; and Z is O or S.