Patent ID: 8802681

Claim:
A pharmaceutical composition, which comprises a trypsin inhibitor and a compound of general formula (I) X—C(O)—NR 1 —(C(R 2 )(R 3 )) n —NH—C(O)—CH(R 4 )—NH(R 5 ) (I) or a pharmaceutically acceptable salt thereof, in which: X represents a residue of a phenolic opioid, wherein the hydrogen atom of the phenolic hydroxyl group is replaced by a covalent bond to —C(O)—NR 1 —(C(R 2 )(R 3 )) n —NH—C(O)—CH(R 4 )—NH(R 5 ); R 1 represents a (1-4C)alkyl group; R 2 and R 3 each independently represents a hydrogen atom or a (1-4C)alkyl group; n represents 2 or 3; R 4 represents —CH 2 CH 2 CH 2 NH(C═NH)NH 2 or —CH 2 CH 2 CH 2 CH 2 NH 2 , the configuration of the carbon atom to which R 4 is attached corresponding with that in an L-amino acid; and R 5 represents a hydrogen atom, an N-acyl group, or a residue of an amino acid, a dipeptide, or an N-acyl derivative of an amino acid or dipeptide.