Patent ID: 8088624

Claim:
A method of determining the severity of thrombophilia, comprising measuring a von Willebrand factor-cleaving protease from a sample of bodily fluid from a patient suffering from one or more diseases selected from the group consisting of pulmonary embolism, cerebral infarction, veno-occlusive disease, and deep vein thrombosis, wherein said bodily fluid is selected from the group consisting of whole blood, blood plasma, and serum; and correlating the quantitative level of von Willebrand factor-cleaving protease in the sample to that which would be present in a normal person, with a lower level present in the sample being indicative of an increased severity of thrombophilia; wherein the measuring of von Willebrand factor-cleaving protease is performed by sandwich assay using at least one monoclonal antibody selected from the group consisting of WH10 accession number FERM BP-08174, WH63.1 accession number FERM BP-08175, and WH2-22-A1 accession number FERM BP-08483.