Patent ID: 8809550

Claim:
A compound of formula (I): or a pharmaceutically-acceptable salt, solvate or hydrate thereof, wherein R 1 is selected from wherein Z is selected from CF 3 , alkoxy, CF 3 O, halogen, cyano and C 1 -C 4 alkyl optionally substituted with one or more halogens; Y is selected from halogen, alkoxy, hydroxyl, CF 3 O and cyano; W is oxygen; R 3 and R 4 are independently selected from C 1 -C 4 alkyl optionally substituted with one or more fluoro or hydroxyl groups, or R 3 and R 4 and the carbon to which they are attached together form a 3-6 membered cycloalkyl ring, wherein one or more carbons may be optional substituted with one or more fluoro or hydroxyl groups, and wherein one of the carbons is optionally an oxygen or nitrogen; and R 2 is an aryl or heteroaryl group substituted with one or more C 1 -C 6 alkyl, C(O)NHR″, SO 2 R″, SO 2 NHR″, cyano, hydroxyl, alkoxy, C(S)NHR″, C(O)OR″, CH 2 (CH 2 ) m Q, halogen or a 5-6 membered heteroaryl group, where R″ is selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl and C 1 -C 6 alkenyl; m is an integer selected from 0 to 6; and Q is selected from C(O)NHR″, SO 2 R″, SO 2 NHR″, cyano, hydroxyl, alkoxy, C(S)NHR″ and C(O)OR″; or R 2 is a substituted or unsubstituted alkyl or heterocyclic group.