Patent ID: 8835604

Claim:
An isolated variant of an antimicrobial peptide comprising the amino acid sequence of SEQ ID NO: 2, comprising a substitution at one or more of positions 1, 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 15, 17 and 19 of the amino acid sequence of SEQ ID NO: 2,wherein (a) the variant has antimicrobial activity; (b) the number of substitutions is 1-11; (c) the variant comprises at least one or more non-conservative substitutions; (d) the variant comprises at least one non-conservative substitutions at position 5, 9 or 17 of the amino acid sequence of SEQ ID NO: 2; and (e) when the amino acid residues at positions 5 and 17 of the amino acid sequence of SEQ ID NO: 2 are Y and the variant comprises a non-conservative substitution at position 9, the variant comprises either (i) a conservative substitution at least at one of positions 8 or 13 or (ii) a non-conservative substitution at position 15.