Patent ID: 7312048

Claim:
Recombinant actinomycete cells that are modified to contain nucleic acid molecules which comprise at least two modules that encode a modular polyketide synthase (PKS) functional in catalyzing the synthesis of a polyketide, said modules comprising at least one nucleotide sequence which encodes a PKS acyl transferase (AT) activity; at least one nucleotide sequence that encodes a PKS ketoacyl carrier protein synthase (KS) activity; and at least one nucleotide sequence that encodes a PKS acyl carrier protein (ACP) activity; said modules operatively linked to one or more control sequences, whereby a functional modular PKS is produced in said cell; with the proviso that when the nucleic acid molecules comprise a nucleotide sequence that encodes a complete modular PKS at least one PKS encoding gene comprising two modules or at least said one of said control sequences is heterologous to the host cell.