Patent ID: 7465546

Claim:
A method of up-regulating the gene expression of Transforming Growth Factor (TGF)-β1, β2, and/or β3 protein in targeted tissue, comprising the steps of: a. generating at least one specific and selective signal having a frequency from 30 kHz to 120 kHz that when applied to a field generating device operatively disposed with respect to said targeted tissue causes the generation of an electric field having an amplitude of about 0.2 to 80 mV/cm in the targeted tissue that is specific and selective for the up-regulation of the gene expression of TGF-β1, β2, and/or β3 protein in said targeted tissue as measured by mRNA when said electric field is applied to the targeted tissue containing said TGF-β1, β2, and/or β3 protein; and b. exposing said targeted tissue to the specific and selective electric field generated by said field generating device upon application of said at least one specific and selective signal thereto for a predetermined duration of time from approximately ½ hour to 24 hours per 24 hour period at a predetermined duty cycle from approximately 10%-100% so as to selectively up-regulate the gene expression of TGF-β1, β2, and/or β3 protein in said targeted tissue as measured by mRNA.