Patent ID: 7067516

Claim:
A tryptase inhibitor compound of formula (I) where: R 5 represents amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen; R 6a represents hydrogen or methyl; X—X is selected from the group consisting of —CH═CH—, —CONR 1a —, —NH—CO—, —NR 1a —CH 2 —, —CH 2 —NR 1a —, —CH 2 O—, —OCH 2 —, —COO—, —OC═O— and —CH 2 CH 2 —; R 1a represents hydrogen, (1–6C)alkyl or phenyl(1–6C)alkyl; L is CONR 1d (CH 2 ) m in which m is 0 or 1 and R 1d is hydrogen, (1–6C)alkyl or phenyl(1–6C)alkyl; Cy is a saturated or unsaturated, mono or poly cyclic, homo or heterocyclic group optionally substituted by one or more groups R 3a — or R 3i X i —; each R 3a independently is hydrogen, hydroxyl, (1–6C) alkoxy, (1–6C)alkyl, (2–6C)alkenyl, (2–6C)alkynyl, (1–6C)alkanoyl, (1–6C)alkylaminoalkyl, hydroxy(1–6C)alkyl, carboxy, (1–6C)alkoxyalkyl, (1–6C)alkoxycarbonyl, (1–6C) alkylaminocarbonyl, amino (1–6C)alkyl, CONH 2 , CH 2 CONH 2 , aminoacetyl, (1–6C)alkanoylamino, hydroxy(1–6C) alkanoylamino, amino(1–6C)alkanoylamino, (1–6C)alkylamino(1–6C) alkanoylamino, di(1–6C)alkylamino(1–6C)alkanoylamino, (1–6C) alkoxycarbonylamino, amino, halo, cyano, nitro, thiol, (1–6C) alkylthio, (1–6C) alkylsulphonyl, (1–6C) alkylsulphenyl, imidazolyl, hydrazido, (16C)alkylimidazolyl, (1–6C) alkylsulphonamido, (1–6C) alkylaminosulphonyl, aminosulphonyl, (1–6C) haloalkoxy, or (1–6C)haloalkyl; X i is a bond, O, NR 1p , CH 2 , CO, CONR 1p , R 1p CO, SO 2 , NR 1p SO 2 or SO 2 NR 1p ; R 3i is phenyl or pyridyl; R 1i is as defined for R 1a Lp is selected from the group consisting of in which R 3 is an amino acid residue, N-(1–6C)alkylaminocarbonyl, N,N-di (1–6C)alkylaminocarbonyl, N-(1–6C)alkylaminoalkanoyl, N-(1–6C) alkanoylamino(1–6C)alkanonyl, C-hydroxyamino(1–6C)alkanoyl, hydroxy(2–6C)alkanoylamino(1–6C)alkanoyl, di(1–6C)alkylaminosulfonyl, hydrogen, hydroxyl, (1–6C)alkoxy, (1–6C)alkanoyloxy, (1–6C) alkyl, (2–6C)alkenyl (2–6C)alkynyl, (3–6C)alkenyloxycarbonyl, (1–6C)alkanoyl, amino(1–6C)alkyl, amido (CONH 2 ), amino(1–6C)alkanoyl, aminocarbonyl (1–50) alkanoyl, hydroxy(1–6C) alkyl, carboxy, hydroxy(1–6C)alkanoyl, (1–6C)alkoxy(1–6C)alkanoyl, (1–6C)alkoxy(1–6C)alkyl, (1–6C)alkoxycarbonyl(1–5C)alkyl, (1–6C)alkoxycarbonyl, (1–6C)alkanoylamino, amino, halo, cyano, nitro, thiol, (1–6C) alkylthio, (1–6C)alkylsulfonyl, (1–6C)alkylsulphenyl or hydrazido; R 3y represents R 3 or a group of formula R k -G2-X a — in which G 2 is absent or represents (1–3C)alkanediyl, X a is absent or represents O, S, SO, SO 2 NR L , CO, OCO, COO, CONR L , NR L CO, SO 2 NR L or NR L SO 2 ; R k represents a carbocyclic or heterocyclic group, optionally substituted by R 3 ; and R L represents hydrogen or (1–6C)alkyl; R 3z is oxo or is as defined for R 3y , X za is CR 2 and X z is O, S or NR z in which R z has a value independently selected from a value for R 3y ; or a physiologically tolerable salt thereof.