Patent ID: 8129537

Claim:
A compound of formula I wherein R 1 is lower alkyl optionally substituted by one or more of halo, cycloalkyl or cycloalkenyl; R 2 is alkyl, alkenyl or alkynyl each optionally substituted by one or more of halo, cycloalkyl or cycloalkenyl; or cycloalkyl or cycloalkenyl each optionally substituted by one or more of halo, methylidene or alkyl; or optionally substituted cyclothioalkyl consisting of a non-aromatic monocyclic or multicyclic ring system of 3 to about 10 ring atoms wherein at least one of the ring atoms is sulphur and the other ring atoms are carbon and the substituted cyclothioalkyl is substituted by one or more halo, or any ring sulphur atom is optionally oxidised to the corresponding S-oxide or S,S-dioxide; or optionally substituted cyclothioalkenyl consisting of a non-aromatic monocyclic or multicyclic ring system of 3 to about 10 ring atoms wherein at least one of the ring atoms is sulphur, the other ring atoms are carbon and the ring system contains a carbon-carbon double bond and the substituted cyclothioalkenyl is substituted by one or more halo or any ring sulphur atoms is optionally oxidised to the corresponding S-oxide or S,S-dioxide; R 3 is optionally substituted aryl or heteroaryl, wherein the substituted aryl or substituted heteroaryl group is substituted by one or more substituents which may be the same or different and are selected from alkyl, aryl, aralkyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkyloxy, carboxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarboxyl, aryloxycarbonyl, aralkyloxycarbonyl, acylamino, aroylamino, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl, alkylthio, arylthio, aralkylthio, Y 1 Y 2 N—, Y 1 Y 2 NCO— or Y 1 Y 2 NSO 2 —, where Y 1 and Y 2 are independently hydrogen, alkyl, aryl, and aralkyl; one of Q 1 , Q 2 and Q 3 is nitrogen and the others of Q 1 , Q 2 and Q 3 are independently CX or CH; Z 1 and Z 2 are independently oxygen or sulfur; Z 3 is —CSCH 2 —, —CS—CS—, —CH 2 —S—, or —CH 2 —SO 2 —, —CSNH 2 ; and X is halo; or N-oxide thereof or a pharmaceutically acceptable salt thereof; with the proviso that R 1 Z 1 and R 2 Z 2 cannot both represent methoxy.