Patent ID: 8012948

Claim:
A method for inhibiting proliferation of brain tumor cells, which comprises: administering to brain tumor cells a siNA agent that reduces the amount of RNA encoding a Fas/FasL apoptosis gating polypeptide in an amount sufficient to inhibit proliferation of the brain tumor cells, wherein the Fas/FasL apoptosis gating polypeptide is a FAPP2 polypeptide or a PATZ1 polypeptide, and wherein the siNA agent comprises one or more of the nucleotide sequences: (SEQ ID NO: 26) 5′-GAUGGAUCUUGUUGGAAAUUU-3′ (SEQ ID NO: 27) 5′-AUUUCCAACAAGAUCCAUCUU-3′ (SEQ ID NO: 28) 5′-GAUGGAUCUUGUUGGAAAUUsU-3′ (SEQ ID NO: 29) 5′-AUUUCCAACAAGAUCCAUCUsU-3′ (SEQ ID NO: 30) 5′-GAuGGAucuuGuuGGAAAuusu-3′ (SEQ ID NO: 31) 5′-AUUUCcAACAAGAUCcAUCUsU-3′ (SEQ ID NO: 32) 5′-GUCUAUGGAAGAAAUAGUUUU-3′ (SEQ ID NO: 33) 5′-UUACUACUACUACUACUACUU-3′ (SEQ ID NO: 34) 5′-GUCUAUGGAAGAAAUAGUUUsU-3′ (SEQ ID NO: 35) 5′-UUACUACUACUACUACUACUsU-3′ (SEQ ID NO: 36) 5′-GucuAuGGAAGAAAuAGuuusU-3′ (SEQ ID NO: 37) 5′-UuACuACuACuACuACuACUsU-3′ wherein s is a phosphorothioate linkage and lowercase nucleotide designations designate a nucleotide having a 2′-O-methyl modification.