Patent ID: 8629177

Claim:
A method of making a lyophilized particle or sphere having a diameter of about 100 to 500 nanometers having a shell comprising poly (D,L-lactide-coglycolide polymer) or polycaprolactone containing delta-9-tetrahydrocannabinol, said method comprising the steps of forming a mixture of poly (D,L-lactide-coglycolide polymer) or polycaprolactone containing delta-9-tetrahydrocannabinol in carbon dioxide held under conditions in which carbon dioxide is a supercritical, critical or near critical fluid, injecting said mixture in a stream in a deareated solution comprising a cross-linking agent in a buffer to form one of more particles or spheres having a diameter of 100 to 500 nanometers and lyophilizing said one or more particles or spheres to form a lyophilized particle or sphere having a diameter of about 100 to 500 nanometers having a shell and comprising poly (D,L-lactide-coglycolide polymer) or polycaprolactone containing delta-9-tetrahydrocannabinol.