Patent ID: 8193359

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein: one of E 1 and E 2 is N and the other is N or C-G 2 ; the dashed line together with the solid line forms an optional double bond; when the dashed line together with the solid line forms a double bond E 3 is CR 8 or N, and when it is a single bond E 3 is CHR 8 , O or NR 2 ; T is O, S, or NR 2 ; B is a bond; Q is a 5-membered heteroaromatic ring; A is (CH 2 ) n , where one CH 2 group may be replaced by O or NR 3 ; n is 0, 1, 2, 3, or 4; G 1 and G 2 are independently hydrogen, halogen, C 1-4 -alkoxy, NR 4 R 44 , or cyano; or C 1-4 -alkyl optionally substituted by hydroxy, NR 4 R 44 , or oxo; D represents NR 1 ; R 1 is C(O)OR 5 or heteroaryl optionally be substituted by one or two groups selected from C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkyl-OH, halogen, C 1-4 -fluoroalkyl, heterocyclyl, C(O)OC 1-4 alkyl; R 2 and R 3 are independently hydrogen or C 1-4 alkyl; R 4 and R 44 are independently hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, or aryl, which may optionally be substituted with 1 or 2 substituents selected from halo, C 1-4 alkyl, CF 3 , C 1-4 alkoxy, cyano, and S(O) 2 Me; or, taken together, R 4 and R 44 may form a 5- or 6-membered heterocyclic ring; R 5 is C 1-8 alkyl, C 2-8 alkenyl or C 2-8 alkynyl, any of which may be optionally substituted by one or more halo atoms, NR 6 R 66 , OR 6 , C(O)OR 6 , OC(O)R 6 or cyano, and may contain a CH 2 group that is replaced by O or S; or a C 3-7 cycloalkyl, aryl, heterocyclyl, heteroaryl, C 1-4 alkyleneC 3-7 cycloalkyl, C 1-4 alkylenearyl, C 1-4 alkyeneheterocyclyl or C 1-4 alkyleneheteroaryl, any of which may be substituted with one or more substituents selected from halo, C 1-4 alkyl, C 1-4 fluoroalkyl, OR 7 , CN, NR 7 R 77 , SO 2 Me, NO 2 or C(O)OR 7 ; R 6 , R 66 , R 7 , and R 77 each independently are hydrogen or C 1-4 alkyl; or, taken together, R 6 and R 66 or R 7 and R 77 may form a 5- or 6-membered heterocyclic ring; R 8 is hydrogen, hydroxy, C 1-4 alkoxy or benzyloxy; R 11 hydrogen; x is 0, 1, 2 or 3; and y is 1, 2, 3, 4 or 5; with the proviso that x+y is 2, 3, 4 or 5.