Patent ID: 7109158

Claim:
A perfume composition of HLA molecules prepared according to a method whereby a) an allele is selected from known HLA alleles of class I such that it differs by at least one feature from other alleles of the HLA class I molecules which occurs in less than 5% of the world's population; or b) HLA alleles of class I are selected which have been produced by mutation of existing HLA alleles of class I and do not occur naturally and thus have an incidence of 0%; and c) the protein for which the selected allele codes is subjected to assembly in the presence of β 2 -microglobulin (β 2 m) by using a plurality of different peptides having a length of typically 7 to 12 amino acids and with N- and C-termini to form soluble HLA class I molecules consisting of the extracellular domains α 1 , α 2 and α 3 , β 2 m and a peptide is formed, whereby the peptide is present in bound form in a peptide binding chain of the HLA molecule formed by the extracellular domains α 1 and α 2 ; and d) the HLA class I molecules thus formed together with the bound peptides are separated from the other constituents in one purification step; and e) the purified HLA class I molecules are subjected to fragmentation with one or more proteases; and f) the substances that are active in producing the odor and are formed in fragmentation are added either as an individual component or as a mixture to a cosmetic preparation, optionally after first separating the other substances.