Patent ID: 8394768

Claim:
A pharmaceutical combination comprising a first composition comprising purified coagulation factors FII, FIX, FX and FVII, and a second composition comprising purified FVIII and/or purified von Willebrand factor (vWF), wherein the pharmaceutical combination has a synergistically increased efficacy in treatment of acquired coagulopathy in a patient compared to treatment with either the first or second composition alone, wherein the first and second compositions are comprised in one single composition, wherein the factors are purified from human plasma and/or from culture medium of cells which recombinantly produce one or more of the factors, wherein the factors are purified to at least 60% purity with respect to other proteins and nucleic acids, and wherein the biological activity of the purified factors is higher per milligram of total protein content as compared to the human plasma or culture medium from which the respective factors were purified.