Patent ID: 8399185

Claim:
An isolated recombinant cell comprising heterologous nucleic acid encoding at least one Nuclear Factor of Activated T cells (NFAT) regulator protein, wherein the heterologous nucleic acid is a mammalian NFAT regulator gene, wherein the NFAT regulator gene is ORAI1, ORAI2, ORAI3, wherein ORAI 1 is encoded by a nucleic acid sequence comprising SEQ ID NO: 1 or a sequence 95% homologous thereto, ORAI 2 is encoded by a nucleic acid sequence comprising SEQ ID NO:2 or a sequence 95% homologous thereto, ORAI 3 is encoded by a nucleic acid sequence comprising SEQ ID NO:3 or a sequence 95% homologous thereto, and wherein the cell comprises a heterologous calcium modulating agent.