Patent ID: 7094778

Claim:
A compound of Formula I wherein: R 1 , R 2 and R 3 are independently in each occurrence hydrogen, halogen, (C 1-6 )-alkyl, —OR′, —SR′, —NR′R″, —SOR′, —SO 2 R′, —COOR′, —OCOR′, —OCONR′R″, —OSO 2 R′,—OSO 2 NR′R″; —NR′SO 2 R″, —NR′COR″, —SO 2 NR′R″, —SO 2 (CH 2 ) 1-3 CONR′R″, —CONR′R″, cyano, haloalkyl, or nitro; or R 1 and R 2 if adjacent, taken together with the carbons to which they are attached may also form a 5- to 7- membered aromatic, saturated or unsaturated ring, optionally incorporating one or two ring heteroatoms chosen from N, S (O) 0-2 , or O, and optionally substituted with (C 1-6 )-alkyl, halo, cyano or lower alkoxy; R′ and R″ are independently in each occurrence hydrogen, (C 1-6 )-alkyl, substituted lower alkyl, (C 0-3 )alkylalkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C 1-3 )-alkyl, heteroaryl-(C 1-3 )-alkyl, heterocyclyl-(C 1-3 )-alkyl, cycloalkylalkyl, cycloalkyl, or R′ and R″ together with the nitrogen they are attached may also form a 5- to 7- membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O) 0-2 ; R 4 is independently in each occurrence (C 1-6 ) alkyl; R 5 is independently in each occurrence (C 1-6 ) alkyl, (C 1-6 ) alkenyl, (C 1-6 ) alkynyl, or cycloalkyl; one of X, Y or Z is independently S, O, or N—R 6 , the others are CH 2 ; R 6 is hydrogen, (C 1-6 )-alkyl, haloalkyl, aryl(C 1-6 )alkyl, heteroaryl(C 1-6 )alkyl, —(C 1-6 )—CR′R′R′, —COOR′, —SO 2 R′, —C(O)R′, —SO 2 (CH 2 ) 0-3 NR′R″, —CONR′R″, —C(O)OCH 2 OC(O)R′, —C(O)OCH 2 SC(O)R′, or —PO(OR′) 2 , where R′ and R″ are as defined above; m is 1; n is 3; or pharmaceutically acceptable salts or solvates thereof.