Patent ID: 7714014

Claim:
A small molecule compound of the formula wherein each of X 1 and X 2 independently N or C, wherein one of X 1 and X 2 is N and one of X 1 and X 2 is C, such that the ring N forms a double bond with whichever of X 1 and X 2 is C; each of R 1 , R 2 and R 3 is independently selected from the group consisting of C 1 -C 6 alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl, optionally substituted with 0-3 R 6 groups each independently selected from the group consisting of H, halogen, C 1 -C 6 alkyl, —OR 7 , —C(O)R 7 , —OC(O)R 7 , —N(R 7 ,R 7 ), —NR 7 S(O) 2 R 7 , —C(O)N(R 7 ,R 7 ), —N(R 7 )C(O)R 7 , —N(R 7 )C(O)N(R 7 ,R 7 ), —C(NR 7 )N(R 7 ,R 7 ), —N(R 7 )C(NR 7 )N(R 7 ,R 7 ) and S(O) m R 7 wherein subscript m is 0, 1 or 2; Y is a direct bond or C 1 -C 4 alkyl; Z is a member selected from the group consisting of C 1 -C 4 alkyl, aryl and heteroaryl; R 4 is H, halogen, —OR 7 , —OC(O)R 7 , —C(O)OR 7 , —N(R 7 ,R 7 ), —NR 7 S(O) 2 R 7 , —C(O)N(R 7 ,R 7 ), —N(R 7 )C(O)N(R 7 ,R 7 ), —C(NR 7 )N(R 7 ,R 7 ), NR 7 C(O)R 7 , and S(O) m R 7 wherein subscript m is 0, 1 or 2; R 5 is H, C 1 -C 6 alkyl, or optionally combined with Y to form a 5 to 6 membered heterocycle; each R 7 is independently H or C 1 -C 6 alkyl; and salts, racemates, disasteriomers, enantiomers, geometric isomers, and prodrugs thereof.