Patent ID: 8722676

Claim:
A compound selected from Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: the solid/dash line indicates a single or double bond; X 1 is CH or N; X 2 is CR 2 where R 2 is H or F; X 3 is CH; Y 1 and Y 2 are independently selected from CH and N; Y 3 is C or N; Y 4 is CR 6 , N or NH; where one or two of Y 1 , Y 2 , Y 3 and Y 4 are N; R 4 is selected from H, F, Cl, CN, and —CH 2 OH; R 5 is selected from —CH 3 , —CH 2 CH 3 , —CH 2 OH, —CH 2 F, —CHF 2 , —CF 3 , —CN, and —CH 2 CH 2 OH; n is 0, 1, 2, 3, or 4; R 6 is selected from H and —CH 3 ; R 7 is selected from the structures: where the wavy line indicates the site of attachment; R 8 is selected from H, —CH 3 , —S(O) 2 CH 3 , cyclopropyl, azetidin-3-yl, oxetan-3-yl, and morpholin-4-yl; and Z is CH.