Patent ID: 7514446

Claim:
A compound of formula (I): wherein: R 1 is selected from the group consisting of H, halo, alkyl, alkenyl, alkynyl; R 2 is selected from the group consisting of cycloalkyl, cycloalkenyl, —(R 7 ) g —C(O)R 6 , —(R 7 ) g —CO 2 R 6 , —(R 7 ) g —C(O)N(R 6 ) 2 , —(R 7 ) g —OR 6 , —O—(R 7 ) g -Ay, —(R 7 ) g —S(O) e R 6 , —(R 7 ) g —N(R 6 ) 2 , —(R 7 ) g —N(R 6 )C(O)R 6 , —(R 7 ) g —CN, —(R 7 ) g —SCN, —NO 2 , —N 3 , and 5- to 9-membered heteroaryl containing 1 or 2 heteroatoms selected from N, O and S; each R 3 is the same or different and is independently H or alkyl; Y is selected from the group consisting of —C(O)R 8 , and —C(S)R 8 , wherein R 8 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, Ay, Het, —OR 6 , —O—(R 7 ) g -Ay, —O—(R 7 ) g -Het, —N(R 6 ) 2 , —N(R 6 )—(R 7 ) g -Ay, —N(R 6 )—(R 7 ) g -Het, —N(R 6 )—(R 7 ) g —OR 6 , —N(R 6 )—(R 7 ) g —C(O)R 6 , —N(R 6 )—(R 7 ) g —CO 2 R 6 , —N(R 6 )—(R 7 ) g —SO 2 R 6 , and —N(R 6 )—(R 7 ) g —N(R 6 ) 2 ; a is 0, 1, 2 or 3; each R 4 is the same or different and is independently selected from the group consisting of halo, alkyl, —(R 7 ) g -cycloalkyl, —(R 7 ) g —C(O)R 6 , —(R 7 ) g —CO 2 R 6 , —(R 7 ) g —C(O)N(R 6 ) 2 , —(R 7 ) g —OR 6 , —(R 7 ) g —S(O) e R 6 , —(R 7 ) g —N(R 6 ) 2 and —(R 7 ) g —N(R 6 )C(O)R; each e is the same or different and is independently 0, 1 or 2; b is 0, 1, 2, 3, 4 or 5; each R 5 is the same or different and is a group of formula (R 7 ) g —R 11 , each R 6 is the same or different and is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl; g is 0 or 1; R 7 is alkylene or alkenylene; Ay is aryl; Het is a 5- or 6-membered heterocycle or heteroaryl containing 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S; R 11 is selected from the group consisting of halo, alkyl, alkenyl, alkynyl, Ay, Het, —C(O)Het, —CO 2 R 6 , —CO 2 Ay, —CO 2 Het, —C(O)N(R 6 ) 2 , —C(O)N(R 6 )Ay, —C(O)N(R 6 )Het, —C(O)N(R 6 )—(R 7 ) g —N(R 6 ) 2 , —C(O)N(R 6 )—(R 7 ) g —CO 2 R 6 , —C(O)N(R 6 )—(R 7 ) g —S(O) e R 6 , —OR 6 , —O—(R 7 ) g -Ay, —O—(R 7 ) g -Het, —O—R 7 —OR 6 , —O—R 7 —N(R 6 ) 2 , —S(O) e R 6 , —S(O) e —(R 7 ) g -Het, —S(O) e —(R 7 ) g —N(R 6 ) 2 , —S(O) e —(R 7 ) g —N(R 6 )Het, —S(O) e N(R 6 )—(R 7 ) g —C(O)Het, —N(R 6 ) 2 , —N(R 6 )—(R 7 ) g -Ay, —N(R 6 )—(R 7 ) g -Het, —N(R 6 )—(R 7 ) g —C(O)R 6 , —N(R 6 )—C(O)—(R 7 ) g -Het, —N(R 6 )—C(O)—(R 7 ) g —N(R 6 ) 2 , —N(R 6 )—C(O)—(R 7 ) g —N(R 6 )Het, —N(R 6 )—C(O)—(R 7 ) g —N(R 6 )—(R 7 —O) h —N(R 6 )—CO 2 R 6 , —N(R 6 )—(R 7 ) g —S(O) e R 6 , —N(R 6 )—(R 7 ) g —S(O) e Het, —N(R 6 )—R 7 —N(R 6 ) 2 , —N(R 6 )—R 7 —OR 6 , —CN, and —N 3 ; and h is 1-20; wherein when R 1 is —CH 3 , R 2 is Br or NO 2 , both R 3 are H, a is 0 and b is 0 or 1 wherein R 5 is —CO 2 H, then Y is not —CO 2 H or a pharmaceutically acceptable salt thereof.