Patent ID: 7531622

Claim:
A grafted homodetic cyclopeptide combining both cell-targeting and therapeutic/diagnostic functions, the cyclopeptide forming a framework that defines a grafted upper face and a grafted lower face; wherein one face is grafted with at least one molecule of therapeutic or diagnostic interest, and the other is grafted with at least one recognition molecule of interest; said cyclopeptide being obtained by a process comprising: synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups, whereby the linear peptide has a terminal glycine residue; intramolecularly cyclizing the resulting protected linear peptide through the terminal glycine residue; substituting some or all of orthogonal protective groups with a protected precursor suitable for grafting a molecule of interest; and grafting at least one molecule of therapeutic or diagnostic interest on one face of the cyclopeptide framework, and at least one recognition molecule of interest on the other face of the cyclopeptide framework; wherein at least one molecule of interest is grafted onto the upper or lower face of the framework via an oxime bond.