Patent ID: 6933306

Claim:
A compound of formula (I) wherein R 1 is OH or NHOH; R 2 is H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclo or heterocycloalkyl (any of which may be optionally substituted with one or more substituents selected from R 6 , W and WR 6 ); and R 3 is H or alkyl; or R 2 , R 3 and the carbon atom to which they are attached together represent a carbocyclic or heterocyclic ring (either of which may be substituted with one or more substituents selected from R 6 , W and WR 6 ); R 4 is alkyl, cycloalkyl, OR 9 , CO 2 R 14 , COR 10 , S(O) q R 10 where q is 0, 1 or 2, CONR 7 R 8 , CN or S(O) q NR 7 R 8 ; two R 4 substituents may be attached to the same carbon atom to form C(R 4 ) 2 , where each R 4 may be the same or different, and C(R 4 ) 2 may represent C═O; R 5 is alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, CF 3 , OR 9 , COR 10 , S(O) q R 10 , CO 2 R 14 , CONR 7 R 8 , S(O) q NR 7 R 8 , halogen, NR 10 OR 11 or CN, or two adjacent R 5 substituents may be combined to form a heterocyclic ring; R 6 is OR 9 , COR 10 , CO 2 R 15 , CONR 7 R 8 , NR 10 R 11 , S(O) q R 10 , S(O) q NR 7 R 8 , ═O, ═NOR 10 , succinimido or the group R 7 and R 8 , which may be the same or different, are each H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heterarylalkyl, heterocycloalkyl or cycloalkylalkyl, or R 7 and R 8 and the nitrogen to which they are attached together represent a heterocyclic ring; R 9 is H, alkyl, CF 3 , CHF 2 , CH 2 F, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heterarylalkyl, heterocycloalkyl or cycloalkylalkyl; R 10 is H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heterarylalkyl, heterocycloalkyl or cycloalkylalkyl; and R 11 is H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heterarylalkyl, heterocycloalkyl, cycloalkylalkyl, COR 12 , CONR 7 R 8 , S(O) q R 12 or S(O) q NR 7 R 8 ; or R 10 and R 11 and the nitrogen to which they are attached together represent a heterocyclic ring; R 12 is OR 9 or R 13 ; R 13 is alkyl, cycloalkyl, aryl, heteroaryl, heterocyclo, arylalkyl, heterarylalkyl, heterocycloalkyl or cycloalkylalkyl; R 14 is H, alkyl or cycloalkyl; R 15 is H, alkyl or cycloalkyl, arylalkyl or heteroarylalkyl; R 16 is H or alkyl; A is heteroaryl; W is alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclo or heterocycloalkyl; each k and m is independently 0, 1, 2 or 3; n is 0 or 1; p is 0, 1 or 2; and p+n=2 or a salt, solvate, hydrate, N-oxide, protected amino, protected carboxy or protected hydroxamic acid derivative thereof.