Patent ID: 7205302

Claim:
A pharmaceutical composition comprising a heterocyclic compound represented by the following general formula (1) or a salt thereof as an active ingredient: wherein R 1 and R 2 are the same or different and each represents an optionally substituted aryl, and the substituents are the same or different and 1 to 3 substituents are selected from the group consisting of halogen, alkyl, haloalkyl, arylalkyl, alkoxy, alkylthio, alkoxyalkyl, alkylsulfonyl, hydroxy, amino, monoalkylamino, dialkylamino, carboxy, cyano and nitro, Y represents N or N→O, Z represents CR 6 ; and R 6 represents hydrogen, alkyl, or halogen, A represents NR 7 or SO, and R 7 represents hydrogen, alkyl, alkenyl or cycloalkyl, D represents alkylene or alkenylene which are optionally substituted with hydroxy, or A and D are combined with each other to form a divalent group represented by the following formula (2): r represents an integer of 0 to 2, q represents an integer of 2 to 3, and t represents an integer of 0 to 4, E represents phenylene or single bond, or D and E are combined with each other to form a divalent group represented by the following formula (3): u represents an integer of 0 to 2, and v represents 0 or 1, G represents O, S, SO, SO 2 , or C(R 8 )(R 9 ), and R 8 and R 9 are the same or different and each represents hydrogen or alkyl, R 3 and R 4 are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, monoalkylcarbamoyl, dialkylcarbamoyl, or a group represented by the following formula (22): R 10 represents amino, monoalkylamino, dialkylamino, hydroxy, optionally substituted alkyl, optionally substituted aryl, optionally substituted aryloxy, or optionally substituted heterocyclic group, and the substituents of alkyl, aryl, aryloxy or heterocyclic group are the same or different and 1 to 3 substituents are selected from the group consisting of halogen, alkyl, haloalkyl, arylalkyl, alkoxy, alkylthio, alkoxyalkyl, alkylsulfonyl, hydroxy, amino, monoalkylamino, dialkylamino, carboxy, cyano and nitro; and a pharmaceutically acceptable carrier.