Patent ID: 7838277

Claim:
A recombinant virus comprising an adenovirus capsid, which capsid comprises one or more fragments of the C68 fiber of SEQ ID NO: 27 fused to a heterologous adenovirus capsid protein, and the capsid further comprises a modified adenovirus C68 penton protein fragment selected from the group consisting of: SEQ ID NO: 12 having a 50 amino acid N-terminal or C-terminal truncation; SEQ ID NO: 12 having a 100 amino acid N-terminal or C-terminal truncation; SEQ ID NO: 12 having a 150 amino acid N-terminal or C-terminal truncation; and SEQ ID NO: 12 having a 200 amino acid N-terminal or C-terminal truncation, said one or more fragments of the C68 fiber selected from the group consisting of: SEQ ID NO: 27 having a 50 amino acid N-terminal or C-terminal truncation; SEQ ID NO: 27 having a 100 amino acid N-terminal or C-terminal truncation; SEQ ID NO: 27 having a 150 amino acid N-terminal or C-terminal truncation; SEQ ID NO: 27 having a 200 amino acid N-terminal or C-terminal truncation, and a fragment of the fiber protein having the sequence of amino acids 247 to 425 of SEQ ID NO:27 wherein said capsid encapsidates a molecule for delivery to a target cell, wherein the molecule comprises an adenovirus 5′ inverted terminal repeat sequence (ITRs), a minigene, and an adenovirus 3′ ITR.