Patent ID: 8748109

Claim:
A method of detecting and/or assessing hepatic damage or injury associated with administration of a drug to a human or animal subject, the method comprising the steps of (a) testing a serum sample obtained from said subject for: (i) a specific serum biomarker of apoptosis; (ii) a specific serum biomarker of necrosis; and (iii) a specific serum biomarker of inflammation; and (b) correlating the presence of said serum biomarkers with a hepatic specific indicator of damage, wherein the serum biomarker of apoptosis is caspase-cleaved K18, the serum biomarker of necrosis is full length K18 and/or the hypoacetylated form of HMGB-1, and the serum biomarker of inflammation is the acetylated form of HMGB-1.