Patent ID: 8088828

Claim:
A method of reducing the severity or frequency of signs and symptoms of benign prostate hyperplasia (BPH) in a subject suffering from BPH, comprising a step of contacting the androgen receptor with a selective androgen receptor modulator (SARM) compound represented by the structure of formula I: wherein G is O; X is O; T is OH, OR, —NHCOCH 3 , or NHCOR; Z is NO 2 , CN, COOH, COR, NHCOR or CONHR; Y is CF 3 , F, I, Br, Cl, CN, C(R) 3 or Sn(R) 3 ; Q is alkyl, halogen, CF 3 , CN, C(R) 3 , Sn(R) 3 , N(R) 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH 3 , NHCSCF 3 , NHCSR, NHSO 2 CH 3 , NHSO 2 R, OR, COR, OCOR, OSO 2 R, SO 2 R, or SR; R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 .