Patent ID: 8178668

Claim:
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: R1 is isoquinolin-3-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl, either of which is optionally substituted with one to four independent R3 groups; X is pyrazolyl, pyridyl, thiazolyl, imidazolyl, furyl, thienyl, pyrrolyl, indolyl, indazolyl, or tetrahydropyridyl; R2 is H, halogen, CN, alkyl, cycloalkyl, bicycloalkyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, amino, aminoalkyl, alkylamino, alkylsulfonyl, C(═O)R4, C(═O)OR4, C(═O)NR5R6, NR7C(═O)R4, NR7C(═O)OR4, NR7C(═O)NR5R6, NR7S(═O) 2 R4, NR7S(═O)R4, aryl, heterocyclyl, heterobicycloalkyl, heterospiroalkyl, heteroaryl, -alkyl-C(═O)R4, -alkyl-C(═O)OR4, -alkyl-C(═O)NR5R6, -alkyl-NR7C(═O)R4, -alkyl-NR7C(═O)OR4, -alkyl-NR7C(═O)NR5R6, -alkyl-NR7SO 2 R4, -alkyl-NR7SOR4, aryl-alkyl, heterocyclyl-alkyl, or heteroaryl-alkyl, any of which is optionally substituted by one or more independent R3 groups; R3 is H, halogen, CN, alkyl, cycloalkyl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, amino, aminoalkyl, alkylamino, alkylsulfonyl, C(═O), C(═S), C(═O)R4, C(═O)OR4, C(═O)NR5R6, NR7C(═O)R4, NR7C(═O)OR4, NR7C(═O)NR5R6, NR7SO 2 R4, NR7SOR4, aryl, heterocyclyl, heteroaryl, -alkyl-C(═O)R4, -alkyl-C(═O)OR4, -alkyl-C(═O)NR5R6, -alkyl-NR7C(═O)R4, -alkyl-NR7C(═O)OR4, -alkyl-NR7C(═O)NR5R6, -alkyl-NR7SO 2 R4, -alkyl-NR7SOR4, aryl-alkyl, heterocyclyl-alkyl, or heteroaryl-alkyl, any of which is optionally further substituted by one or more independent R7 groups; R4 is alkyl, cycloalkyl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, amino, aminoalkyl, alkylamino, dialkylamino, alkylsulfonyl, aryl, heterocyclyl, heteroaryl, aryl-alkyl, heterocyclyl-alkyl, or heteroaryl-alkyl, any of which is optionally further substituted by one or more independent R7 groups; R5 and R6 are each independently H, alkyl, cycloalkyl, or alkoxyalkyl, any of which is optionally substituted by one or more independent R7 groups; or R5 and R6 taken together with the atom that they are attached to form a 4-7 membered saturated or unsaturated heterocycle; wherein said heterocycle is optionally further substituted by one or more independent R7 groups; R7 is H, halogen, alkyl, trifluoroalkyl, alkoxy, CN, cycloalkyl, alkoxyalkyl, aryl, hetaryl, or heterocyclyl; n is 1.