Patent ID: 8575316

Claim:
An antibody or antigen binding fragment thereof comprising: a light chain sequence that comprises a light chain variable region having CDRL1, CDRL2, and CDRL3, wherein CDRL1 comprises the amino acid sequence of SEQ ID NO: 47, CDRL2 comprises the amino acid sequence of SEQ ID NO: 48, and CDRL3 comprises the amino acid sequence of SEQ ID NO: 49, and a heavy chain sequence that comprises a heavy chain variable region having CDRH1, CDRH2, and CDRH3, wherein CDRH1 comprises the amino acid sequence of SEQ ID NO: 44, CDRH2 comprises the amino acid sequence selected from the group consisting of SEQ ID NO: 45 and SEQ ID NO: 97, and CDRH3 comprises the amino acid sequence of SEQ ID NO: 46, wherein the antibody or antigen binding fragment thereof binds a Siglec-15 protein comprising the amino acid sequence of SEQ ID NO: 2 or 4, wherein the light chain sequence is selected from the group consisting of: (a) the light chain sequence comprises amino acid residues 21-238 of the amino acid sequence of SEQ ID NO: 69; (b) the light chain sequence comprises amino acid residues 21-238 of the amino acid sequence of SEQ ID NO: 105; (c) the light chain variable region comprises amino acid residues 21-133 of the amino acid sequence of SEQ ID NO: 69; and (d) the light chain variable region comprises amino acid residues 21-133 of the amino acid sequence of SEQ ID NO: 105 or wherein the heavy chain sequence is selected from the group consisting of: (a) the heavy chain sequence comprises amino acid residues 20-466 of the amino acid sequence of SEQ ID NO: 101; (b) the heavy chain sequence comprises amino acid residues 20-466 of the amino acid sequence of SEQ ID NO: 99; (c) the heavy chain variable region comprises amino acid residues 20-140 of the amino acid sequence of SEQ ID NO: 101; and (d) the heavy chain variable region comprises amino acid residues 20-140 of the amino acid sequence of SEQ ID NO: 99.