Patent ID: 7750131

Claim:
An oligomeric compound having the formula: G-[T-L] j -[R-L] q -R-[L-T] r -E wherein: each T is a monomer of formula II: wherein independently for each monomer having formula II: Bx is a heterocyclic base moiety; Z is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 1 -C 6 alkyl, substituted C 2 -C 6 alkenyl, substituted C 2 -C 6 alkynyl or substituted acyl; each R is a β-D-2′-deoxyribonucleoside; each L is an internucleoside linking group; G and E are each, independently, H, a hydroxyl protecting group or a linked conjugate group; wherein each substituted group is mono or poly substituted with substituent groups independently selected from halogen, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, OJ 1 , SJ 1 , NJ 1 J 2 , N 3 , COOJ 1 , CN, O—C(═O)—NJ 1 J 2 , N(H)C(═NH)NR 1 R 2 or N(H)C(═X)N(H)J 2 wherein X is O or S; each J 1 and J 2 is, independently, H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, substituted C 2 -C 6 alkynyl, C 1 -C 6 aminoalkyl, substituted C 1 -C 6 aminoalkyl or a protecting group; q is from 7 to about 15; j is 0 or from 1 to about 5; r is 0 or from 1 to about 5; the sum of j and r is at least 1; and the sum of j, q and r is from 7 to 39.