Patent ID: 7338965

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z is CH; wherein R 1 is wherein R 9 is: —R C-aryl , —R C-aryl —R C-aryl , or —R C-aryl —R C-heterocycle , and where R C-aryl is phenyl, 1-naphthyl, 2-naphthyl, tetralinyl, indanyl, or dihydronaphthyl, optionally substituted with one, two or three of the following substituents which can be the same or different and are: (1) C 1 -C 6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of C 1 -C 3 alkyl, —F, —Cl, —Br, —I, —OH, —SH, —S(C 1-6 alkyl), —SO 2 (C 1-6 alkyl), —C≡N, —CF 3 , C 1 -C 3 alkoxy, and —NR 1-a R 1-b , where R 1-a and R 1-b are independently —H or C 1 -C 6 alkyl, (2) —OH, (3) —NO 2 , (4) —F, —Cl, —Br, —I, (5) —CO—OH, (6) —C≡N, (7) —(CH 2 ) 0-4 —CO—NR N-2 R N-3 , where R N-2 and R N-3 are independently —H or C 1 -C 6 alkyl, (8) —(CH 2 ) 0-4 —CO—(C 1 -C 12 alkyl), (9) —(CH 2 ) 0-4 —CO—R 1-aryl , where R 1-aryl is phenyl, (10) —(CH 2 ) 0-4 —CO—O—R N-5 , where R N-5 is C 1 -C 6 alkyl or —(CH 2 ) 0-2 —(R 1-aryl ), where R 1-aryl is phenyl. (11) —(CH 2 ) 0-4 —SO 2 —(C 1 -C 12 alkyl), (12) —(CH 2 ) 0-4 —NR N-2 R N-3 , (13) —(CH 2 ) 0-4 —O—CO—(C 1 -C 6 alkyl), (14) —(CH 2 ) 0-4 —O—CO—N(R N-5)hd 2 , (15) —(CH 2 ) 0-4 —O—(R N-5 ) 2 , (16) —(CH 2 ) 0-4 —S—(R N-5 ) 2 , or (17) —(CH 2 ) 0-4 —O—(C 1 -C 6 alkyl optionally substituted with one, two, three, four, or five of —F); and R C-heterocycle is selected from the group consisting of: morpholinyl, thiomorpholinyl, piperazinyl, pyrrolidinyl, pyrrolinyl, tetrahydropyranyl, piperidinyl, tetrahydrofuranyl, and tetrahydrothienyl; and wherein R 2 is phenyl, optionally substituted with one, two or three radicals selected from CF 3 , OCF 3 , hydroxyl, halo, C 1 -C 2 -alkyl, C 1 -C 2 -haloalkyl, cyano, carboxyl, C 1 -C 2 -alkoxycarbonyl, C 1 -C 2 -hydroxyalkyl, thioalkyl, aminosulfonyl, C 1 -C 2 -alkylaminosulfonyl, methyl C 1 -C 2 -haloalkoxy, amino, C 1 -C 2 -alkylamino, phenylamino, nitro, C 1 -C 2 -alkoxy-C 1 -C 2 -alkyl, C 1 -C 2 -alkylsulfinyl, C 1 -C 2 -alkoxy and C 1 -C 3 -alkylthio.