Patent ID: 8748462

Claim:
A compound of formula I′A or I′B: or a pharmaceutically acceptable salt, stereoisomer, or a mixture thereof, wherein G is CR 11a ; K is CR 11b ; L is CR 11c ; X is O; J is CR c R d ; wherein R c and R d are H; W is CH; Y is CH or N; Z is CH; A is selected from —H, —(C 1 -C 12 )alkyl; —(C 2 -C 12 )alkenyl; —(C 1 -C 12 )alkyl-O—(C 1 -C 4 )alkyl; —(C 1 -C 12 )alkyl-OH; —(C 1 -C 12 )alkyl-O—(C 2 -C 4 )alkenyl; —(C 2 -C 12 )alkenyl-O—(C 1 -C 4 )alkyl; —(C 2 -C 12 )alkenyl-OH; —(C 2 -C 12 )alkenyl-O—(C 2 -C 4 )alkenyl; —O—(C 1 -C 12 )alkyl; —O—(C 2 -C 12 )alkenyl; S(C 1 -C 12 )alkyl; —S—(C 2 -C 12 )alkenyl; —S(O)—(C 1 -C 12 )alkyl; —S(O)—(C 2 -C 12 )alkenyl; —S(O) 2 —(C 1 -C 12 )alkyl; or —S(O) 2 —(C 2 -C 12 )alkenyl; further wherein the alkyl and alkenyl groups of —(C 1 -C 12 )alkyl, —(C 2 -C 12 )alkenyl, —(C 1 -C 12 )alkyl-O—(C 1 -C 4 )alkyl, —(C 1 -C 12 )alkyl-O—H, —(C 1 -C 12 )alkyl-O—(C 2 -C 4 )alkenyl, —(C 2 -C 12 )alkenyl-O—(C 1 -C 4 )alkyl, —(C 2 -C 12 )alkenyl-OH, —(C 2 -C 12 )alkenyl-O—(C 2 -C 4 )alkenyl, —O—(C 1 -C 12 )alkyl, and —O—(C 2 -C 12 )alkenyl are unsubstituted or are substituted with from 1 to 4 substituents selected from —F, —Cl, —OH, (═O), —NH 2 , NH(C 1 -C 4 )alkyl, —N((C 1 -C 4 )alkyl) 2 , unsubstituted —(C 1 -C 2 )alkyl, or unsubstituted —O—(C 1 -C 2 )alkyl; R 1 is H or —(C 1 -C 6 )alkyl; R 1a is —H; R 1b is —H; R 1b′ is —H; R 1d is —H; R 1d′ is —H; R 2 is —F or —Cl; R 3 is —O—(C 1 -C 3 )alkyl; R 7 and R 8 are —H; R 11a is selected from —H, —F, —Cl, —(C 1 -C 4 )alkyl, or —O(C 1 -C 4 )alkyl; R 11b and R 11c are —H; R 12a and R 12b are —H; R 12c is selected from —H, —F, —Cl, —(C 1 -C 4 )alkyl, or —O(C 1 -C 4 )alkyl; m is 0; and q is selected from 0, 1, or 2; wherein the indicates that the R 1a and —C(═O)—O—R 1 may be attached to either side of the ring to which the is attached and either R or S stereochemistry is allowed.