Patent ID: 8252935

Claim:
A compound having the general Formula (I) wherein is: R 0 is H or F; R 1 is selected from the group consisting of H, F, alkyl selected from the group CH 3 , C 2 H 5 , i-C 3 H 7 , n-C 3 H 7 , i-C 4 H 9 , n-C 4 H 9 , sec-C 4 H 9 , tert-C 4 H 9 ; alkenyl selected from C 2 H 3 , i-C 3 H 5 , n-C 3 H 5 , n-C 4 H 7 , i-C 4 H 7 , sec-C 4 H 7 ; wherein said alkyl and alkenyl groups are optionally substituted with one, two, or three substituents independently selected from the group consisting of F, Cl, Br, I and CF 3 ; R 2 is selected from the group consisting of H, cyclohexyl, SO 2 CH 3 , alkyl selected from the group consisting of CH 3 , C 2 H 5 , i-C 3 H 7 , n-C 3 H 7 , i-C 4 H 9 , n-C 4 H 9 , sec-C 4 H 9 , tert-C 4 H 9 , CH 2 CH 2 CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH(CH 3 ) 2 , CH 2 CH 2 C(CH 3 ) 3 , CH(CH 2 CH 3 ) 2 , and C(O)CH 2 CH(CH 3 ) 2 ; alkenyl selected from the group consisting of C 2 H 3 , i-C 3 H 5 , n-C 3 H 5 , n-C 4 H 7 , i-C 4 H 7 , sec-C 4 H 7 , and CH 2 CH═CHCH(CH 3 ) 2 ; wherein said alkyl and alkenyl groups are optionally substituted with F, Cl, Br, I, CF 3 , -heteroaryl-(R 10 ) n , or wherein R 10 is CF 3 , OCF 3 , H, F, Cl, OCH 3 , C (1-4) alkyl, or CN; and n is 1, 2, or 3; alternatively, R 2 can be two C (1-4) alkyl groups, so that their attached nitrogen is quaternized; R 3 is H, or C (1-4) alkyl-R 11 ; wherein R 11 is CF 3 , OCF 3 , H, F, Cl, OCH 3 , C (1-4) alkyl, or CN; and m is 1, 2, or 3; R 6 is selected from the group consisting of H, F, Cl, Br, I, CN, OH, C(O)N(C (1-4) alkyl) 2 , S(O) 2 C (1-4) alkyl, SO 2 N(C (1-4) alkyl) 2 , S(O)N(C (1-4) alkyl) 2 , N(C (1-4) alkyl)S(O) 2 C (1-4) alkyl, N(C (1-4) alkyl)S(O)C (1-4) alkyl, S(O) 2 C (1-4) alkyl, N(C (1-4) alkyl)S(O) 2 N(C (1-4) alkyl) 2 , SC (1-4) alkyl, N(C (1-4) alkyl) 2 , N(C (1-4) alkyl)C(O)C (1-4) alkyl, N(C (1-4) alkyl)C(O)N(C (1-4) alkyl) 2 , N(C (1-4) alkyl)C(O)OC (1-4) alkyl, OC(O) N(C (1-4) alkyl) 2 , C(O)C (1-4) alkyl, C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy; wherein said alkyl and alkoxy are optionally substituted with one, two, or three substituents selected from the group consisting of F, Cl, Br, and I; R 4 , R 5 , R 7 , and R 8 are independently selected from the group consisting of CF 3 , H, F, Cl, OCH 3 , C (1-4) alkyl, and CN; R 9 is H or alkenyl selected from C 2 H 3 , i-C 3 H 5 , n-C 3 H 5 , n-C 4 H 7 , i-C 4 H 7 , sec-C 4 H 7 ; wherein said alkyl and alkenyl groups are optionally substituted with one, two, or three substituents independently selected from the group consisting of F, Cl, Br, I and CF 3 ; or a pharmaceutically acceptable salts thereof.