Patent ID: 7781438

Claim:
A compound of formula (I) wherein R 1 is a radical —(CH 2 ) n —NR 3 R 4 , located on positions 6, 7 or 8, where n is 0, 1 or 2; and each of R 3 and R 4 , independently, is hydrogen; optionally-substituted C 1-6 -alkyl; C 3-6 -cycloalkyl; carboxy-C 1-6 -alkoxy; C 2-4 -alkenyl; or C 1-6 -alkyl-carbonyl; or R 3 and R 4 form, together with the nitrogen atom to which they are bound, a heterocyclic residue; R 2 is hydrogen; halogen; CF 3 ; OH; CN; SH; NH 2 ; NO 2 ; —CHO; C(O)NH 2 ; optionally-substituted C 1-4 -alkyl; C 1-4 -alkylthio; C 1-4 -alkoxy; C 1-4 -alkyl-sulfoxide; C 1-4 -alkyl-sulfone; NHC 1-4 -alkyl; N(C 1-4 -alkyl) 2 ; C 2-4 -alkenyl; C 1-4 -alkyl-carbamoyl; or (C 1-4 -alkyl) 2 -carbamoyl; ring B may further be substituted by a halogen on position 4; R is a radical of formula (a), (b), (c) or (d), where R a is hydrogen; optionally-substituted C 1-6 -alkyl; C 4-8 -cycloalkyl or an optionally-substituted heterocyclic residue; each of R b , R c , and R d , independently, is hydrogen; halogen; CF 3 ; CN; optionally-substituted C 1-6 -alkyl; C 1-15 -alkoxy optionally interrupted by one or two oxygen atom(s) and optionally-substituted; carbamoyl-C 1-6 -alkoxy; (C 1-4 -alkyl)carbamoyl-C 1-6 -alkoxy; (C 1-4 -alkyl) 2 carbamoyl-C 1-6 -alkoxy; carboxy-C 1-6 -alkoxy; or C 1-6 -alkoxy-carbonyl; or is of the formula O—(CH 2 ) p —NR x R y , wherein each of R x and R y , independently, is hydrogen or C 1-4 -alkyl; and p is 2, 3 or 4; or is of the formula —(CH 2 ) o —NR v ,R w , wherein each of R v and R w , independently, is hydrogen; C 1-4 -alkylC 1-6 -alkoxy; C 1-4 -alkyl-NH—C 1-4 -alkyl; or C 1-4 -alkyl-N(C 1-4 -alkyl) 2 ; and o is 1, 2, 3 or 4; and R e is hydrogen; halogen; CF 3 ; CN; C 1-6 -alkyl; or C 1-6 -alkoxy; or R a and R b form, together with the chain to which they are attached, an optionally-substituted heterocyclic residue; and each of R c , R d and R e , independently, is hydrogen; halogen; C 1-6 -alkyl; or C 1-6 -alkoxy; provided that i) when R is a radical of formula (b), (c) or (d), then R 1 is on position 7; ii) when R is a radical of formula (a), and R 1 is on position 6 or position 7; n is 1; R 2 is halogen or C 1-4 -alkyl; ring B is not substituted on position 4; and either i) each of R 3 and R 4 , independently, is hydrogen or C 1-4 -alkyl or ii) R 3 and R 4 form, together with the nitrogen atom to which they are bound, a heterocyclic residue, then at least one of R a , R b , R c , R d and R e is other than hydrogen or C 1-4 -alkyl; and/or iii) when R 1 is on position 6 and is —NH 2 ; ring B is not substituted on position 4; R is a radical of formula (a); each of R 2 , R 3 , R 4 , R b , R c , R d and R e is hydrogen; and R a is other than hydrogen or C 1-4 -alkyl; or a physiological hydrolysable derivative or salt, thereof.