Patent ID: 6962911

Claim:
A compound of formula (1), or a pharmaceutically acceptable salt or hydrate thereof, wherein R 1 is H; C 1 -C 3 alkyl optionally substituted with one or more fluoro atoms; or C 3 -C 6 cycloalkyl; R 2 is H; a halogen atom; C 1 -C 6 alkyl optionally substituted with OH, C 1 -C 3 alkoxy C 3 -C 6 cycloalkyl, or with one or more fluoro atoms; C 3 -C 6 cycloalkyl; C 2 -C 6 alkenyl; or C 2 -C 6 alkynyl; R 3 is H; C 1 -C 6 alkyl optionally substituted with OH, C 1 -C 3 alkoxy, C 3 -C 6 cycloalkyl, or with one or more fluoro atoms; C 3 -C 6 cycloalkyl; C 2 -C 6 alkenyl; or C 2 -C 6 alkynyl; R 4 is C 1 -C 6 alkyl optionally substituted with C 3 -C 6 cycloalkyl or with one or more fluoro atoms; C 2 -C 6 alkenyl; C 2 -C 6 alkynyl; or C 3 -C 6 cycloalkyl; R 5 is SO 2 NR 6 R 7 ; NHSO 2 NR 6 R 7 ; NHCOCONR 6 R 7 ; NHSO 2 R 8 ; NCHOR 8 ; or phenyl or heterocyclyl either of which is optionally substituted with one or more fluoro atoms or C 1 -C 3 alkyl; R 6 and R 7 are each independently H or C 1 -C 6 alkyl optionally substituted with OH, CO 2 H, C 1 -C 3 alkoxy, C 3 -C 6 cycloalkyl, or with one or more fluoro atoms; or together with the nitrogen atom to which they are attached from either a mono-cyclic chosen from imidazole, aziridine, azetidine, pyrrolidine, piperidine, morpholine, piperazine and homopiperazine, or a bicyclic ring chosen from 2,5-diazabicyclo[2.2.1]heptane and 3,7-diazabicyclo[3.3.0]octane, wherein said group is optionally substituted with R 9 ; R 8 is C 1 -C 6 alkyl optionally substituted with one or more fluoro atoms; or C 3 -C 7 cycloalkyl; R 9 is C 1 -C 6 alkyl optionally substituted with one or more halide atoms, OH, C 1 -C 3 alkoxy which is optionally substituted with one or more fluoro atoms, CO 2 R 10 , NR 11 R 12 , C═NR 13 (NR 14 R 15 ), or with a tetrazole group which is optionally substituted with C 1 -C 3 alkyl; or one more nitrogen containing heteroaryl group which is optionally substituted with one or more fluoro atoms; R 10 is H; or C 1 -C 4 alkyl optionally substituted with OH, NR 11 R 12 , one or more fluoro atoms, or with a nitrogen containing heterocyclic ring chosen from pyrrolidine, piperidine, piperazine, morpholine, pyrrole, and imidazole wherein nitrogen atom is directly bound to C 1 -C 4 alkyl; R 11 and R 12 are each independently H or C 1 -C 4 alkyl; R 13 is H; C 1 -C 4 alkyl optionally substituted with one or more fluoro atoms; or C 3 -C 6 cycloalkyl; and R 14 and R 15 are each independently H or C 1 -C 4 alkyl optionally substituted with one or more fluoro atoms; C 3 -C 6 cycloalkyl; or together with the nitrogen atom to which they are attached form a pyrrolidinyl, piperidino, morpholino, piperazinyl, or homopiperazinyl, group wherein said group is optionally substituted with C 1 -C 3 alkyl.