Patent ID: 6989398

Claim:
A composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein, Ar 1 is a substituted or unsubstituted heteroaryl group selected from indolyl, substituted indolyl, benzofuranyl, substituted benzofuranyl, furanyl, substituted furanyl, substituted thienyl, isothiazolyl, substituted isothiazolyl, pyrazolyl, and substituted pyrazolyl and substituted phenyl such that when Ar 1 is substituted heteroaryl it bears a substituent which is selected from halogen, alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, halo(C 1-C 4 )alkoxy, nitro, cyano, —NR 7 C(O)R 8 , —NR 7 R 8 , phenyl and substituted phenyl, and when Ar 1 is substituted phenyl it bears a substituent which is selected from halogen, halo(C 1-C 4 )alkyl, (C 1 -C 4 )alkoxy, halo(C 1-C 4 )alkoxy, nitro, cyano, —NR 7 R 8 , phenyl and substituted phenyl, wherein R 7 and R 8 are members independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, substituted (C 1 -C 8 )alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C 1-C 4 )alkyl and substituted aryl(C 1 -C 4 )alkyl, or R 7 and R 8 taken together with the nitrogen to which each is attached form a 5-, 6- or 7-membered ring optionally having additional heteroatoms at the ring vertices; X is a member selected from the group consisting of, S and N—R 1 , wherein, R 1 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, substituted (C 1 -C 8 )alkyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C 1 -C 4 )alkyl, substituted aryl(C 1 -C 4 )alkyl, CN, —C(O)R 2 , —OR 3 , —C(O)NR 3 R 4 , and —S(O) 2 NR 3 R 4 , wherein, R 2 is a member selected from the group consisting of (C 1 -C 8 )alkyl, substituted (C 1 -C 8 )alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, alkaryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C 1 -C 4 )alkyl and substituted aryl(C 1 -C 4 )alkyl; R 3 and R 4 are each members independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, substituted (C 1 -C 8 )alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C 1-C 4 )alkyl and substituted aryl(C 1 -C 4 )alkyl, or R 3 and R 4 can be combined with the nitrogen to which each is attached to form a 5-, 6- or 7-membered ring optionally having additional heteroatoms at the ring vertices; and Y is a member selected from the group consisting of halogen, C 1 -C 4 alkyl, C 1 -C 4 substituted alkyl, —OCH 3 and —OCF 3 .