Patent ID: 6858619

Claim:
A compound having the formula: wherein A and B independently are CR′, wherein each R′ is independently selected from the group consisting of hydrogen, (C 1 -C 5 )alkyl, arylalkyl, —C(O)R 7 , —CO 2 R 8 and —C(O)NR 5 R 6 ; V is either a bond and W is —N(R″)—, or V is —N(R″)— and W is a bond, wherein R″ is hydrogen or (C 1 -C 5 )alkyl; Z is —N(R)—CH 2 —, wherein R is selected from the group consisting of hydrogen, (C 1 -C 7 )alkyl, heterocycloalkyl(C 1 -C 7 )alkyl, aryl, arylalkyl, —C(O)R 7 , —CO 2 R 8 , —C(O)NR 5 R 6 , —S(O) m NR 5 R 6 and —S(O) m R 7 ; each R 1 is independently selected from the group consisting of halogen, (C 1 -C 5 )alkyl, perfluoro(C 1 -C 5 )alkyl, —OR′″, —SR′″, aryl, aryl(C 1 -C 5 )alkyl, —NO 2 , —NR 5 R 6 , —C(O)R 7 , —CO 2 R 8 , —C(O)NR 5 R 6 , —N(R 5 )C(O)R 7 , —N(R 5 )CO 2 R 9 , —N(R 7 )C(O)NR 5 R 6 , —S(O) m NR 5 R 6 , —S(O) m R 7 , —CN and —N(R 5 )S(O) m R 9 , wherein R′″ is selected from the group consisting of hydrogen, (C 1 -C 5 )alkyl, aryl and aryl(C 1 -C 5 )alkyl; R 2 and R 3 are independently selected from the group consisting of hydrogen, —OR′″, ═O, —CN, (C 1 -C 5 )alkyl and aryl, wherein R′″ is selected from the group consisting of hydrogen, (C 1 -C 5 )alkyl, aryl and aryl(C 1 -C 5 )alkyl; R 4 is selected from the group consisting of hydrogen, —OR′″, —C(O)R 7 , —CO 2 R 8 , —C(O)NR 5 R 6 , —CN, (C 1 -C 5 )alkyl and aryl, wherein R′″ is selected from the group consisting of hydrogen, (C 1 -C 5 )alkyl, aryl and aryl(C 1 -C 5 )alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, aryl and aryl(C 1 -C 5 )alkyl or combined to form a 4-, 5-, 6-, 7- or 8-membered ring containing from one to three atoms selected from the group consisting of O, N, S, and Si; R 7 and R 8 are independently selected from the group consisting of hydrogen, alkyl, aryl and aryl(C 1 -C 5 )alkyl; R 9 is selected from the group consisting of alkyl, aryl and aryl(C 1 -C 5 )alkyl; the subscript m is an integer from 1 to 2; the subscript n is an integer from 1 to 4; and wherein is a substituted benzene ring; with the proviso that R 2 is not hydrogen when A and B are both CH, V is a bond, and W is —N(R″)—.