Patent ID: 7321001

Claim:
A compound having the formula (XVI): or a pharmaceutically acceptable salt or prodrug thereof, wherein Y is —S(O) 2 —; X is —O—; R 2 is a substituted or unsubstituted benzene ring; R 3 and R 5 are independently selected from the group consisting of hydrogen, halogen, (C 1 -C 8 )alkyl, fluoro(C 1 -C 4 )alkyl, hetero(C 2 -C 8 )alkyl, aryl, heteroaryl, aryl(C 1 -C 4 )alkyl, —NR′R″, —OR′, —NO 2 , —CN, —C(O)R′, —CO 2 R′, —(O)NR′R″, —C 1 -C 4 )alkylene-C(O)NR′R″, —(O) m R′, —S(O) k NR′R″, —OC(O)OR′, —OC(O)R′, —C(O)NR′R″, N(R′″)C(O)NR′R″, —(R″)C(O)R′ and —N(R″)C(O)OR′; R 4 is selected from the group consisting of —C(O)NR 12 R 13 and —NHC(O)-alkyl; R 6 is selected from the group consisting of hydrogen, halogen, (C 1 -C 8 )alkyl, fluoro(C 1 -C 4 )alkyl, hetero(C 2 -C 8 )alkyl, aryl, heteroaryl, aryl(C 1 -C 4 )alkyl, —NR′R″, —NO 2 , —CN, —C(O)R′, —CO 2 R′, —C(O)NR′R″, —(C 1 -C 4 )alkylene-C(O)NR′R″, —S(O) m R′, —S(O) k NR′R″, —OC(O)OR′, —OC(O)R′, —OC(O)NR′R″, —N(R′″)C(O)NR′R″, —N(R″)C(O)R′and —N(R″)C(O)OR′; R 10 is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, fluoro(C 1 -C 4 )alkyl, hetero(C 2 -C 8 )alkyl, aryl, heteroaryl, aryl(C 1 -C 4 )alkyl, —C(O)R′, —CO 2 R′, —C(O)NR′R″, —S(O) m R′ and —S(O) k NR′R″; L is a divalent linkage selected from the group consisting of a single bond, (C 1 -C 6 )alkylene and (C 2 -C 4 )heteroalkylene; Z is —CO 2 R 12 ; R 12 and R 13 are independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, hetero(C 2 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl and heteroaryl; each R 14 is independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, fluoro(C 1 -C 4 )alkyl, —OR′, —NR′R″, —NO 2 , —CN, —C(O)R′ and aryl; each R′, R″ and R′″ is independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, cyclo(C 3 -C 8 )alkyl, aryl and aryl(C 1 -C 4 )alkyl; each subscript k is independently 0, 1 or 2; each subscript m is independently 0, 1, 2 or 3; and the subscript n is 0, 1, 2, 3 or 4.