Patent ID: 7652000

Claim:
A method for treating a surface condition in an animal, comprising administering to said animal an effective amount of a compound having the structure: or its pharmaceutically acceptable salts, hydrates, or solvates, wherein: R 1 and R 2 are selected independently from the group consisting of optionally substituted alkyl, optionally substituted aryl, aralkyl, and optionally substituted heteroaryl; R 3 and R 4 are selected from the group consisting of: hydrogen, alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, heterocyclyl, —COaryl, —OCOalkyl, —OCH 2 CH 2 OH, O(CH 2 ) 3 CO 2 H, 2-(morpholino)ethoxy, —(CH 2 ) k OH (where k=1, 2 or 3), —CH 2 NH 2 , —CH 2 NHalkyl, —CH 2 N(alkyl) 2 , —CO 2 H, —CO 2 alkyl, —CONH 2 , —OH, alkoxy, aryloxy, —SH, —S-alkyl, —S-aryl, —SO 2 alkyl, —SO 2 N(alkyl) 2 , —SO 2 NHalkyl, —SO 2 NH 2 , —SO 3 H, —SCF 3 , —CN, halogen, —CF 3 , —NO 2 , amino, substituted amino, —NHSO 2 alkyl, and —CONHalkyl, wherein R 3 and R 4 are optionally substituted; and R 5 and R 6 are selected independently from the group consisting of: hydrogen, alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, heterocyclyl, —(CH 2 )OH (n=1 to 3), —CH 2 NH 2 , —CH 2 NHalkyl, —CH 2 N(alkyl) 2 , halogen, —CHO, —CH═NOH, —CO 2 H, —CO 2 -alkyl, —S-alkyl, —SO 2 -alkyl, —SO-alkyl, —S-aryl, —SO 2 N(alkyl) 2 , —SO 2 NHalkyl, —SO 2 NH 2 , amino, alkoxy, —CF 3 , —SCF 3 , —NO 2 , —SO 3 H, and OH; and wherein said surface condition is selected from the group consisting of acne vulgaris, acne rosacea, atopic dermatitis and periodontal disease.