Patent ID: 8206336

Claim:
A method for reducing or eliminating pain associated inserting a needle into the skin of a subject comprising prior to insertion of the needle into the skin a. applying a transdermal delivery device to the skin of the subject, wherein the transdermal delivery device comprises at least one re-sealable injection port and at least one local anesthetic reservoir for delivering the anesthetic to the skin of a subject, wherein the local anesthetic reservoir is compartmentalized into at least two separate reservoirs, and wherein the at least one local anesthetic reservoir surrounds the at least one re-sealable injection port, and the re-sealable injection port is separated from the local anesthetic reservoir by an impermeable substrate; and b. applying an electromotive force to the skin of the subject, wherein the electromotive force can be applied to the skin prior to the application of the transdermal delivery device to the skin, after the application of the transdermal delivery device to the skin, or a combination thereof.