Patent ID: 7968050

Claim:
An ophthalmic product, comprising a sealed container which has been subjected to sterilization by autoclave, wherein the sealed container includes an aqueous solution and an ophthalmic device immersed in the aqueous solution, wherein the ophthalmic device is made of a poly(oxyalkylene)-containing polymeric material, wherein the aqueous solution comprising: an alpha-oxo-multi-acid or salt thereof in an amount sufficient to have a reduced susceptibility to oxidative degradation of the poly(oxyalkylene)-containing polymeric material; one or more buffer agents selected from group consisting of TRIS (tris(hydroxymethyl)aminomethane), bis-aminopolyols, triethanolamine, ACES (N-(2-hydroxyethyl)-2-aminoethanesulfonic acid), BES (N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid), HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), MES (2-(N-morpholino)ethanesulfonic acid), MOPS 3-[N-morpholino]-propanesulfonic acid, PIPES (piperazine-N,N′-bis(2-ethanesulfonic acid), TES (N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid), and salts thereof; an organic tonicity-adjusting agent in an amount sufficient to provide an osmolarity of from about 200 to about 450 milli-osmole in 1000 ml (unit: mosm/l), wherein the organic tonicity-adjusting agent is selected from the group consisting of glycerol, sorbitol, xylitol, mannitol, propylene glycol, polyethylene glycol (PEG) with a molecular weight of about 400 Da or less, and mixtures thereof, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of 15 mM or less and about 5000 ppm sodium chloride.