Patent ID: 8211927

Claim:
An isoxazole-3-carboxamide derivative having the general Formula I wherein R 1 is phenyl, each of which optionally substituted by 1-3 substituents selected from halogen, (C 1-4 )alkyl and (C 1-4 )alkyloxy, the alkyl and alkyloxy group being optionally substituted with halogen; R 2 is (C 1-3 )alkyl, (C 3-8 )cycloalkyl, cyano or halogen, provided that when R 2 is cyano R 3 is not phenyl; R 3 is (C 1-8 )alkyl, (C 2-8 )alkenyl, or (C 2-8 )alkynyl, each of which optionally substituted by one or 2 substituents independently selected from halogen, hydroxy and phenyl, optionally substituted by hydroxy or amino; or R 3 is (C 3-10 )cycloalkyl, (C 3-8 )cycloalkenyl or (C 3-8 )cycloalkyl(C 1-3 )alkyl, each cycloalkyl group may be fused to a benzo group, and each cycloalkyl group may be substituted by oxo, hydroxyimino, amino, hydroxy, carboxy, cyano, (C 1-3 )alkyl or hydroxy(C 1-3 )alkyl; or R 3 is a saturated 4-8-membered heterocyclic ring containing 1 or 2 heteroatoms selected from NR 5 , O, S and SO 2 , optionally substituted by hydroxyl or oxo; or R 3 is phenyl, naphthyl or pyridyl, each of which may be fused to a 5- or 6-membered saturated heterocyclic ring containing 1 or 2 heteroatoms selected from NR 5 , O and S, and each of which may be substituted by amino, halogen, hydroxy, hydroxyimino, oxo, mercapto, (C 1-3 )-alkyl, (C 1-3 )-alkyloxy or hydroxy(C 1-3 )alkyl, each alkyl group optionally substituted by one or more halogens; or R 3 is a bicyclic heteroaromatic ring system containing 1-3 heteroatoms selected from N, O and S, which may be substituted by hydroxy, amino, (C 1-3 )alkyl or hydroxy-(C 1-3 )alkyl; R 4 is H or (C 1-4 )alkyl; or R 4 together with R 3 and the N to which they are bonded form a saturated 4-8 membered ring, optionally containing a further heteroatom selected from O, S and SO 2 , the ring being optionally substituted by oxo, hydroxyimino, amino, hydroxy, carboxy, carboxamido, (C 1-3 )alkyl, hydroxy(C 1-3 )alkyl, (C 1-3 )-alkyloxy; (C 1-4 )alkylcarbonylamino or hydroxyl(C 1-3 )alkylaminocarbonyl; R 5 , where present, is H, (C 1-4 )alkyl, (C 1-4 )alkylcarbonyl or (C 1-4 )alkyloxycarbonyl; or a pharmaceutically acceptable salt thereof, with the proviso that N,N-dimethyl-4-bromo-5-phenylisoxazole-3-carboxamide and N,N-diethyl-4-cyano-5-phenylisoxazole-3-carboxamide are excluded.