Patent ID: 7687473

Claim:
A method for potentiating the uptake and efficacy of an antifolate which acts via inhibition of dihydrofolate reductase (DHFR) on the inhibition of growth of cells in an individual, wherein the individual has a condition selected from the group consisting of cancer, rheumatoid arthritis and psoriasis, comprising administering to the individual an effective amount of a potentiating agent selected from the group consisting of 5-amino-4-imidazolecarboxamide, 5-amino-4-imidazolecarboxamide riboside or a combination thereof and the antifolate at a concentration at which the antifolate inhibits DHFR such that the cells are simultaneously exposed to the antifolate and the potentiating agent and whereby the uptake of the antifolate into the cells and the efficacy of the antifolate is enhanced.