Patent ID: 8389661

Claim:
An amphiphilic polymer-BMP complex comprised of an amphiphilic polymer and a BMP, wherein the BMP is in the form of a complex with the amphiphilic polymer as confirmable by gel coelectrophoresis and wherein the amphiphilic polymer-BMP complex is physically and chemically stable, and completely soluble in water at physiological pH at a BMP concentration of 1.2 mg/ml, and wherein: the amphiphilic polymer is formed of a hydrophilic polysaccharide skeleton that includes hydrophobic substituents and hydrophilic groups according to the following general formula (I): R and R′, which may be the same or different, represent a bond or a chain comprising from 1 to 18 carbon atoms, said chain optionally being branched and/or unsaturated and optionally comprising one or more heteroatoms, F and F′, which may be the same or different, represent an ester, a thioester, an amide, a carbonate, a carbamate, an ether, a thioether or an amine, X represents a hydrophilic group selected from the group consisting of carboxylates, sulphates, sulphonates, phosphates and phosphonates, Y represents a hydrophilic group selected from the group consisting of sulphates, sulphonates, phosphates and phosphonates, Hy represents a hydrophobic group selected from the group consisting of: linear or branched C 8 to C 30 alkyls which may be unsaturated and/or contain one or more heteroatoms, linear or branched C 8 to C 18 alkylaryls or a linear or branched C 8 to C 18 arylalkyl which may be unsaturated and/or may contain one or more heteroatoms, C 8 to C 30 polycycles which may be unsaturated and/or may contain one or more heteroatoms, and excluding benzylamine, n and o are from 1 to 3, h represents the mole fraction of [F—R-[Hy] n ] with respect to a monomer unit of the polysaccharide, from 0.01 to 0.5, x represents the mole fraction of [F′—R′—[X] o ] with respect to a monomer unit of the polysaccharide, from 0 to 2.0, y represents the mole fraction of [Y] with respect to a monomer unit of the polysaccharide, and is 0, the BMP is selected from the group of therapeutically active BMPs (bone morphogenetic proteins), and the amphiphilic polymer/BMP mass ratio is lower than or equal to 700.