Patent ID: 8293729

Claim:
A compound of the formula (I): wherein: Ar is aryl or heteroaryl, wherein said aryl and heteroaryl are optionally substituted with 1-5 R 4 ; R 1 at each occurrence is independently C 1-4 alkyl, F, hydroxy, C 1-4 alkyl -O—, —CO 2 R 7 , or —C(═O)N(R 6 ) 2 ; R 2 at each occurrence is independently C 1-4 alkyl, F, hydroxy, or C 1-4 alkyl-O—; R 3 is R Alk , aryl-C 1-4 alkyl, heterocycle-C 1-4 alkyl, —C(═O)R 6 , —CO 2 R 5 , —SO 2 R 5 , —C(═X)N(R 6 ) 2 , aryl, or heterocycle, wherein each alkyl, R Alk , aryl, and heterocycle group is optionally substituted with 1-4 substituents independently of each other selected from R 8 ; R 4 at each occurrence is independently halogen, cyano, hydroxy, R Alk , —NO 2 , —C(═O)H, —C(═O)R 5 , —C 1-3 -alkyl-C(═O)R 5 , —CO 2 H, —CO 2 R 5 , —C(═O)N(R 6 ) 2 , —C 1-3 -alkyl-C(═O)N(R 6 ) 2 , —SO 2 N(R 6 ) 2 , —S(═O)R 5 , —S(═O) 2 R 5 , —S(═O) 2 —O—R 5 , R Alk —O—, R Alk —S—, —N(R 6 ) 2 , aryl, aryl-C 1-6 alkyl, heterocycle, heterocycle-C 1-6 alkyl, —NR 6 C(═O)R 5 , —NR 6 S(═O) 2 R 5 , —NR 6 C(═O)N(R 6 ) 2 , —NR 6 C(═O)OR 7 , —NR 6 C(═NR 6 )N(R 6 ) 2 , or —NR 6 S(═O) 2 N(R 6 ) 2 , wherein each alkyl, R Alk , aryl and heterocycle is optionally substituted with 1-5 substituents independently of each other selected from R 8 ; R 5 is R Alk , heterocycle, aryl, heterocycle-C 1-3 -alkyl or aryl-C 1-3 -alkyl, wherein each alkyl, R Alk , heterocycle and aryl group is optionally substituted with 1-4 substituents independently of each other selected from R 8 ; R 6 at each occurrence is independently H, R Alk , heterocycle, heterocycle-C 1-6 -alkyl, aryl or aryl-C 1-3 -alkyl, wherein each R Alk , heterocycle, aryl and alkyl are optionally substituted with 1-4 halogen, hydroxy, —N(R 7 ) 2 , C 1-4 alkyl-O—, and —CO 2 R 7 ; R 7 at each occurrence is independently H or C 1-4 alkyl; R 8 at each occurrence is independently cyano, hydroxy, R Alk , aryl, aryl-C 1 -6 alkyl, heterocycle, heterocycle-C 1-6 alkyl, halogen, oxo, C 1-4 haloalkyl, —NO 2 , —C(═O)H, —CO 2 R 7 , —OC(═O)R Alk , —C(═O)N(R 6 ) 2 , —SO 2 N(R 6 ) 2 , —S(═O)R Alk , —S(═O) 2 R Alk , C 1-6 alkyl-O—, haloC 1-4 alkyl-O—, —N(R 6 ) 2 , —SR 6 , —NR 6 C(═O)R Alk , —NR 6 S(═O) 2 R Alk , —NR 6 C(═O)OR Alk , —NR 6 C(═O)N(R 6 ) 2 , or —NR 6 S(═O) 2 N(R 6 ) 2 , wherein each R Alk , alkyl, aryl and heterocycle are optionally substituted with 1-4 substituents independently of each other selected from halogen, hydroxy, —N(R 7 ) 2 , C 1-4 alkyl-O—, —NR 6 CO 2 R 6 , —NR 6 SO 2 R 6 , and —CO 2 R 7 ; R Alk at each occurrence is independently C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-3 -alkyl, C 4-8 -cycloalkenyl or C 4-8 -cycloalkenyl-C 1-3 -alkyl; X denotes O or S; n at each occurrence is 0, 1, or 2; p at each occurrence is 0 or 1; and q is 0, 1, or 2, including any tautomers and stereoisomers thereof, or a salt thereof.