Patent ID: 7696231

Claim:
An oxindole hydrazide of formula (II) wherein A is O or a bond; B is independently optionally substituted phenyl, naphthyl, phenantrenyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, [1,3]thiazolo [3,2-b][1,2,4]triazolyl, carbazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, benzo (2, 1, 3) oxadiazolyl, benzo (1,2,5) oxadiazolyl, 1,2,4-oxadiazolyl, 1,2, 5-oxadiazolyl, 1,3,4-oxadiazolyl, tetrazolyl, 1,3,4-triazinyl, 1,2,3-triazinyl, benzofuryl, [2,3- dihydro]benzofuryl, isobenzofuryi, benzothienyl, benzotriazolyl, isobenzothienyl, indolyl, isoindolyl, 3H-indolyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, pyridazinyl, pyrirnidyl, quinolizinyl, quinazolinyl, pthalazinyl, quinoxalinyl, cinnolinyl, napthyridinyl, quinolyl, isoquinolyl, tetrazolyl, 5,6,7,8-tetrahydroquinolyl, 5,6,7,8-tetrahydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl, benzoquinolyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, oxolanyl, pyrolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, pyridyl, imidazolidinyl, 1,2,4-oxadiazolidinyl, 1,2,5-oxadiazolidinyl, 1,3,4-oxadiazolidinyl, isoxazolidinyl or morpholinyl; R 8 is selected in the group consisting of H, halogen, cyano, (C 1 -C 6 )alkyl, aryl, heteroaryl, —SO—R 9 , —SO 2 —R 9 ,(C 1 -C 6 )alkyl-SO 2 —R 9 , —NO 2 , —N(R 9 ) 2 , (C 1 -C 6 )-alkyl-O—R 9 , —SR 9 , —SO 2 —R 9 , —(C═O)O—R 9 , —(C═O)—R 9 , —(C═O)N(R 9 ) 2 , —(C═O)NH—R 9 , —(C═O)NR 9 —N(R 9 ) 2 , —NR 9 —(C═O)—N(R 9 ) 2 , —NR 9 —(SO 2 —R 9 ), —NH—(C═O)—R 9 , (C 1 -C 6 )-alkyl-NH—(C═O)—R 9 , —NR 9 —(C═O)—R 9 wherein R 9 is selected from the group consisting of H, C 3 -C 8 cycloalkyl, 3-8 membered heterocycloalkyl which may contain 1-2 further heteroatoms selected from O, N or S, (C 1 -C 6 )-alkyl-heterocycloalkyl wherein said heterocycloalkyl may contain 1-2further heteroatoms selected from O, N or S, aryl, (C 1 -C 6 )-alkyl-aryl, (C 1 -C 6 )-alkoxy-aryl, heteroaryl, (C 1 -C 6 )-alkyl-heteroaryl or (C 1 -C 6 )-alkoxy-heteroaryl, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl-COOR 10 wherein R 10 is H or (C 1 -C 6 )alkyl or —NH 2 m′ is 0 or 1; p is an integer from 1 to 3; with the proviso that the following compounds are excluded: