Patent ID: 8551976

Claim:
A compound of Formula I: wherein: X is O, —C(═O)O—, or —NHC(═O)O—; Y is CH 2 or —CHCH—; Z is aryl or arylaryl; X′ is O or S; A is aryl n is an integer from 1 to 4; each R 1 is independently selected from the group consisting of: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heterocyclo, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, alkoxy, halo, mercapto, azido, cyano, formyl, carboxylic acid, hydroxyl, nitro, acyl, aryloxy, alkylthio, amino, alkylamino, arylalkylamino, disubstituted amino, acylamino, acyloxy, ester, amide, sulfoxyl, sulfonyl, sulfonate, sulfonic acid, sulfonamide, urea, alkoxylacylamino, and aminoacyloxy; R 2 and R 3 are each independently H, alkyl, or hydroxy; R 4 is alkyl, cycloalkyl, heterocyclo, or aryl; R 5 and R 6 are independently selected H, alkyl, or haloalkyl, or together form an alkylene bridge, which alkylene bridge may be unsubstituted or substituted from 1 to 4 times with alkyl, halo, a fused cycloalkyl or a fused aryl ring; and pharmaceutically acceptable salts or prodrugs thereof.