Patent ID: 8414871

Claim:
A topical composition comprising: (a) an active compound for topical delivery through the stratum corneum, wherein said active compound is complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a poly(alkylene oxide) and the middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having a structure according to the formula: wherein X is Z is a number between 2 and about 100, inclusive that provides a middle block with a weight-average molecular weight between about 1000 and about 25,000 g/mol; R 1 is CH═CH or (CH 2 ) n wherein n is from 0 to 18, inclusive; R 2 is selected from the group consisting of hydrogen and straight and branched alkyl, benzyl, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from the group consisting of a bond and straight and branched alkylene, alkoxylene, alkylarylene and alkoxyarylene groups containing up to 18 carbon atoms, wherein m for each A is independently selected to have a weight-average molecular weight between about 1000 and about 15,000 g/mol; and (b) a pharmaceutically acceptable carrier for topical delivery.