Patent ID: 7501428

Claim:
A compound having the formula: wherein R 1 is lower alkyl or X is selected from lower alkylene, cyclolower alkylene containing from 3 to 6 carbon atoms and hydroxy lower alkylene; is selected from an aryl ring, cyclolower alkyl ring containing from 3 to 6 carbon atoms, a 4 to 6 membered heterocycloalkyl ring containing from 3 to 5 carbon atoms and from 1 to 2 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur, and a 5 or 6 membered heteroaromatic ring containing from 1 to 2 hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen; R 5 and R 6 are independently selected from the group consisting of hydrogen, hydroxy, hydroxy-lower alkyl, lower alkyl, halogen, perfluro-lower alkyl and lower alkoxy; R 3 is selected from hydrogen, —NHR 7 and R 4 is selected from hydrogen, lower alkyl and —O(CH 2 CH 2 O) y —R 10 ; R 7 is hydrogen or lower alkyl; R 8 and R 10 are lower alkyl; n is an integer from 0 to 1; and y is an integer of from 0 to 3; with the proviso that when n is 0 and R 1 is lower alkyl then R 3 /R 4 cannot both be hydrogen; and N-oxides of compounds where R 1 contains a nitrogen in the heteroaromatic ring, sulfones where R 1 contains a sulfur in the heterocycloalkyl ring or heteroaromatic ring; and pharmaceutically acceptable salts thereof.