Patent ID: 8278337

Claim:
A compound of the formula: or pharmaceutically acceptable salts or esters thereof, wherein X is N; Y is CR 5 wherein R 5 is H; R 1A is H; R 2A is H; R 3 is —C(O)NR 8 R 9 ; R 4 is —C(O)NR 6 R 7 ; R 6 is H; R 7 is alkyl; R 8 is H; R 9 is selected from the group consisting of: (1) heteroarylalkyl-, and (2) substituted heteroarylalkyl wherein said substituted heteroarylalkyl is substituted with 1 to 3 substituents independently selected from the group consisting of: (a) —NH 2 , (b) —NH(C 1 to C 6 )alkyl, (c) —N((C 1 to C 6 )alkyl) 2 wherein each alkyl is independently selected, (d) alkyl, (e) halo, (f) aryl, (g) substituted aryl wherein said substituted aryl is substituted with 1 to 3 substituents independently selected from the group consisting of: (i) —SO 2 R 20 , (ii) —OR 21 , (iii) -halo, (iv) —CN, (v) —CF 3 , (vi) aminoalkyl-, (vii) —S(O)R 26 , and (viii) alkyl, (h) heterocycloalkyl, (i) heteroaryl, (j) substituted aryl substituted with 1 to 3 substituents independently selected from the group consisting of: alkyl, —CF 3 , F, Cl, and Br, (k) substituted heteroaryl, substituted with 1 to 3 substituents selected from the group consisting of: (i) alkyl, (ii) halo, (iii) CN, (iv) NH 2 , (v) —NH(C 1 -C 6 alkyl), (vi) —N(C 1 -C 6 alkyl) 2 wherein each alkyl is independently selected, (vii) —CF 3 , (viii) substituted aryl wherein said substituted aryl is substituted with 1 to 3 substitutents independently selected from the group consisting of: —S(O) 2 R 42 and —CN, and (ix) —C(O)NR 44 R 46 , (l) alkylamino-, (m) heterocycloalkyl-alkyl-amino-, (n) alkylaminoalkylamino-, (o) —NHC(O)OR 30 , and (p) —NHC(O)NR 32 R 34 ; R 20 is selected from the group consisting of: (1) alkyl, (2) dialkylamino (wherein each alkyl is independently selected), (3) —NH 2 , (4) alkylamino, (5) heterocycloalkyl, and (6) substituted heterocycloalkyl wherein said substituted heterocycloalkyl is substituted with 1 to 2 substitutents independently selected from the group consisting of: —C(O)OR 40 ; R 21 is alkyl; R 26 is alkyl; R 30 is alkyl; Each R 32 and R 34 is independently selected from the group consisting of: H, alkyl, aryl, aryl substituted with a —OH group, and heteroaryl; R 40 is alkyl; and Each R 44 and R 46 is independently selected from the group consisting of: H and alkyl.