Patent ID: 8895563

Claim:
A method for controlling an angiogenesis regulated disease or disorder comprising, contacting a subject with an effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl unit having the formula: R 4 and R 5 are each independently chosen from: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, C 3 -C 6 branched, or C 3 -C 6 cyclic alkyl; iii) substituted or unsubstituted phenyl; iv) substituted or unsubstituted heteroaryl; or R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms; said substitutions are independently chosen from one or more C 1 -C 6 linear, C 3 -C 6 branched, or C 3 -C 6 cyclic alkyl, halogen, hydroxyl, or cyano units; R 6 is a unit chosen from: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, C 3 -C 6 branched, or C 3 -C 6 cyclic alkyl; iii) substituted or unsubstituted phenyl; and iv) substituted or unsubstituted heteroaryl; R 1 is chosen from: i) hydrogen; ii) C 1 -C 6 linear or C 3 -C 6 branched alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted benzyl; R 2 is chosen from: i) C 1 -C 6 linear or C 3 -C 6 branched alkyl; or ii) C 1 -C 6 linear or C 3 -C 6 branched alkoxy; R 3 is hydrogen or C 1 -C 4 linear or C 3 -C4 branched alkyl; or a pharmaceutically acceptable salt thereof; wherein the angiogenesis regulated disease or disorder is chosen from skeletal muscle and myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease.