Patent ID: RE39558

Claim:
A compound of the formula I : wherein: A is CH 2 ; B, D and E are CH; Y is (a) phenyl, optionally substituted with 1-3 substituents independently selected from R 4 ; (b) naphthyl, optionally substituted with 1-3 substituents independently selected from R 4 ; (c) C 3 -C 8 cycloalkyl, optionally substituted with 1-2 substituents independently selected from R 4 R 4 ; (d) C 3 -C 8 cycloalkenyl, optionally substituted with 1-2 substituents independently selected from R 4 ; (e) a five membered heterocycle containing up to two heteroatoms selected from the group consisting of -O-, and -NR 2 - and -S(O) n - , optionally substituted with 1-3 substituents independently selected from R 4 ; (f) a six membered heterocycle containing up to two heteroatoms selected from the group consisting of -O-, and -NR 2 - and -S(O) n - , optionally substituted with 1-3 substituents independently selected from R 4 ; or (g) a bicyclic ring system consisting of a five or six membered heterocyclic ring fused to a phenyl ring, said heterocyclic ring containing up to two heteroatoms selected from the group consisting of -O-, and -NR 2 -, NR 2 - and -S(O) n -, optionally substituted with 1-3 substituents independently selected from R 4 . ; Z 1 is (a) -O(CH 2 ) p CR 5 R 6 -; (b) -O(CH 2 ) p W(CH 2 ) q ; or (c) -OCHR 2 CHR 3 -; G is -NR 7 R 8 W is (a) -CH 2 -; (b) -CH═CH-; (c) -O-; (d) -NR 2 -; (e) -S(O) n -; ( f ) (g) -CR 2 (OH)-; (h) -CONR 2 -; or (i) -NR 2 CO-; (j) or (k) -C═C-; R 2 and R 3 are independently (a) hydrogen; or (b) C 1 -C 4 alkyl; R 4 is (a) hydrogen; (b) halogen; (c) C 1 -C 6 alkyl; (d) C 1 -C 4 , alkoxy; (e) C 1 -C 4 acyloxy; (f) C 1 -C 4 alkylthio; (g) C 1 -C 4 alkylsulfinyl; (h) C 1 -C 4 alkylsulfonyl; (i) hydroxy (C 1 -C 4 )alkyl; (j) aryl (C 1 -C 4 )alkyl; (k) -CO 2 H; (l) -CN; (m) -CONHOR; (n) -SO 2 NHR; (o) -NH 2 ; (p) C 1 -C 4 alkylamino; (q) C 1 -C 4 dialkylamino; (r) -NHSO 2 R; (s) -NO 2 ; (t) -aryl; or (u) -OH . ; R 5 and R 6 are independently C 1 -C 8 alkyl or together form a C 3 -C 10 carbocyclic ring; R 7 and R 8 in ring form may optionally be substituted with up to three substituents independently selected from C-C 6 alkyl, halogen, alkoxy, hydroxy and carboxy; a ring formed by R 7 and R 8 may be optionally fused to a phenyl ring; e is 1 or 2; p is 0, 1, 2 or 3; q is 0, 1, 2 or 3; and optical and geometric isomers thereof; and nontoxic pharmacologically acceptable acid addition salts, N-oxides, esters, and quaternary ammonium salts thereof or an optical or geometric isomer thereof; or a nontoxic pharmacologically acceptable acid addition salt, N- oxide, ester, or quaternary ammonium salt thereof .