Patent ID: 7528143

Claim:
A compound having the structure (A): wherein: X is selected from a group consisting of a bond, O, SO 2 , and CH 2 ; Y is selected from a group consisting of a bond or NR 9 ; or X and Y taken together is a bond; each of R 1 and R 2 is independently selected from a group consisting of H, C 1 -C 6 alkyl, cycloalkyl; or R 1 and R 2 taken together is a bond; or R 1 and R 2 taken together form a moiety selected from a group consisting of (CH 2 ) m , (CH 2 ) r —S—(CH 2 ) m , (CH 2 ) r —SO—(CH 2 ) m , (CH 2 ) r —SO 2 —(CH 2 ) m , (CH 2 ) r —NR 9 —(CH 2 ) m , and (CH 2 ) r —O—(CH 2 ) m ; each of p, q, r, n, m is independently an integer having the value between 0 and 6, R 9 is selected from a group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 branched alkyl, C 1 -C 6 aminoalkyl, and C 1 -C 6 hydroxyalkyl; G 0 is selected from a group consisting of N, O, H, and CH, G is CH or C when bonded to X; R 5 methyl; wherein each of R 6 and R 7 is independently selected from a group consisting of C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl or aminoalkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 alkoxy, a halogen, CF 3 , OCF 3 , SO 2 H, SO 2 (C 1 -C 6 alkyl), SO 2 -heterocycle, SO 2 -cycloalkyl, SO 2 N(C 1 -C 6 alkyl)H, SO 2 N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), SO 2 NH(C 1 -C 6 cycloalkyl), SO 2 NH-heterocycle, (SO 2 N(C 1 -C 6 branched alkyl)H, NO 2 , CN, OH, CONH 2 , CO—(C 1 -C 6 alkyl), COOH, COO—(C 1 -C 6 alkyl), and NHCO—(C 1 -C 6 alkyl), and R 8 is independently selected from the group consisting of H, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, C 1 -C 6 hydroxyalkyl or aminoalkyl, C 1 -C 6 cycloalkyl, halogen, CF 3 , OCF 3 , SO 2 H ,SO 2 (C 1 -C 6 alkyl), SO 2 -heterocycle, SO 2 -cycloalkyl, SO 2 N(C 1 -C 6 alkyl)H, SO 2 N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), SO 2 NH(C 1 -C 6 cycloalkyl), SO 2 NH-heterocycle, (SO 2 N(C 1 -C 6 branched alkyl)HNO 2 , CN, OH, CONH 2 , CO—(C 1 -C 6 alkyl), COOH, COO—(C 1 -C 6 alkyl), and NHCO—(C 1 -C 6 alkyl); A is selected from a group consisting of NH, and N—(C 1 -C 6 alkyl); G 1 is CH; G 2 is CR 7 , with each group R 7 independent of every other group R 7 ; and R 3 and R 4 , taken together form a heterocyclic ring system, or a pharmaceutically acceptable salt thereof.