Patent ID: 8758830

Claim:
A compound of Formula IIa: or stereoisomers, or tautomers or pharmaceutically acceptable salts thereof, wherein: A is a direct bond or CR a R b ; R 1 is selected from the group consisting of hydrogen, halogen, CN, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), C 3 -C 6 cycloalkyl, a 4 to 6 membered heterocyclic, phenyl, and a 5 or 6 membered heteroaryl, wherein the alkyls, alkenyl, cycloalkyl, heterocyclic, phenyl or heteroaryl are optionally substituted with one or more groups selected from the group consisting of halogen, CN, CF 3 , C 1 -C 3 alkyl, —O(C 1 -C 3 alkyl), and NR c R d ; R 2 is selected from the group consisting of C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl), —NH(C 1 -C 6 alkyl), a saturated or partially unsaturated C 3 -C 6 cycloalkyl, phenyl, a saturated or partially unsaturated 4 to 6 membered heterocyclic, a 5 or 6 membered heteroaryl, an 8 to 10 membered bicyclic aryl, an 8 to 10 membered bicyclic heterocyclic, and an 8 to 10 membered bicyclic heteroaryl, wherein the alkyls, cycloalkyl, phenyl, heterocyclics, heteroaryls and aryl are optionally substituted with one or more groups selected from the group consisting of OH, CN, halogen, oxo (except not on phenyl, aryl or heteroaryl), CF 3 , cyclopropyl, cyclopropylmethyl, —SO 2 R i , C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), NR e R f , and phenyl, wherein the phenyl is optionally substituted with one or more groups selected from the group consisting of OH, CN, halogen, CF 3 , C 1 -C 3 alkyl, —O(C 1 -C 3 alkyl), and NR g R h ; R 3 and R 4 are independently hydrogen or C 1 -C 4 alkyl optionally substituted with OH, F, —O(C 1 -C 3 alkyl) or C 3 -C 6 cycloalkyl, or R 3 and R 4 together with the atoms to which they are attached form a 5 or 6 membered ring; R 5 is hydrogen or CH 3 , or A is CR a R b , R a and R b are hydrogen, and R 3 and R 5 together with the atoms to which they are attached form a 5 or 6 membered ring; R 6 is selected from the group consisting of hydrogen, F, OH, —OCH 3 , C 1 -C 3 alkyl and cyclopropyl, or A is a direct bond, R 6a is hydrogen and R 3 and R 6 together with the atoms to which they are attached form a 5 or 6 membered ring; R 6a is selected from the group consisting of hydrogen, F, OH, and CH 3 ; R 7 is hydrogen, or A is CR a R b and R 3 and R 7 together with the atoms to which they are attached form a 5 or 6 membered ring; R a is hydrogen, or R 4 and R b are absent and R 3 and R a together with the atoms to which they are attached form an aromatic 5 or 6 membered ring; R b is hydrogen or absent; R c and R d are independently hydrogen or C 1 -C 3 alkyl, or R c and R d together with the atom to which they are attached form a 5 or 6 membered ring; R e and R f are independently hydrogen or C 1 -C 3 alkyl; R g and R h are independently hydrogen or C 1 -C 3 alkyl; and R i is C 1 -C 3 alkyl.