Patent ID: 7351857

Claim:
A compound of Formula I or a pharmaceutically acceptable salt, C 1-6 ester or C 1-6 amide thereof, wherein each of R 1 and R 2 is independently H, C 1-6 alkyl, (CH 2 ) m NR a R b , (CH 2 ) m OR 8 , (CH 2 ) m NH(CO)R 8 , or (CH 2 ) m CO 2 R 8 , where each of R a , R b , and R 8 is independently H or C 1-6 alkyl, or R 1 and R 2 taken together with the carbon atom to which they are attached are a C 3-7 cycloalkyl; m is between 1 and 6; n is 1 or 2; X is O or S; wherein X is at the 5 or 6 position when n is 1; and wherein X is at the 6 or 7 position when n is 2; R 3 is H, phenyl, C 1-3 alkoxy, C 1-3 alkylthio, halo, cyano, C 1-6 alkyl, nitro, NR 9 R 10 , NHCOR 10 , CONHR 10 ; and COOR 10 ; and R 3 is ortho or meta to X; R 4 is H or —(C 1-5 alkylene)R 15 , where R 15 is H, C 1-7 alkyl, [di(C 1-2 alkyl)amino](C 1-6 alkylene), (C 1-3 alkoxyacyl)(C 1-6 alkylene), C 1-6 alkoxy, C 3-7 alkenyl, or C 3-8 alkynyl, wherein R 4 has no more than 9 carbon atoms; R 4 can also be —(C 1-5 alkylene)R 15 wherein R 15 is C 3-6 cycloalkyl, phenyl, phenyl-O—, phenyl-S—, or a 5-6 membered heterocyclyl with between 1 and 2 heteroatoms selected from N, O, and S; Y is NH, NH—CH 2 , and O; each of R 5 and R 7 is independently selected from H, C 1-6 alkyl, halo, cyano, nitro, COR 11 , COOR 11 , C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, phenyl, NR 11 R 12 and 5-6 membered heterocyclyl with between 1 and 2 heteroatoms selected from N, O, and S; R 6 is selected from C 1-6 alkyl, halo, cyano, nitro, COR 13 , COOR 13 , C 1-4 alkoxy, C 1-4 alkylthio, hydroxy, phenyl, NR 13 R 14 and 5-6 membered heterocyclyl with between 1 and 2 heteroatoms selected from N, O, and S; in addition, either R 5 and R 6 or R 6 and R 7 may be taken together to be a bivalent moiety, saturated or unsaturated, selected from —(CH 2 ) 3 —, —(CH 2 ) 4 —, and (CH 1-2 ) p N(CH 1-2 ) q , p is 0-2 and q is 1-3, where the sum (p+q) is at least 2; each of R 9 and R 10 is independently C 1-6 alkyl; each of R 11 , R 12 , R 13 and R 14 is independently H or C 1-6 alkyl; wherein each of the above hydrocarbyl and heterocarbyl moieties may be substituted with between 1 and 3 substituents independently selected from F, Cl, Br, I, amino, methyl, ethyl, hydroxy, nitro, cyano, and methoxy.