Patent ID: 8569474

Claim:
A composition comprising an antisense oligomeric compound and two sense oligomeric compounds wherein: each of the sense oligomeric compounds is complementary to a separate region of the antisense oligomeric compound and one of the sense oligomeric compounds forms a duplex region with the antisense oligomeric compound starting at the 5′-end of the antisense oligomeric compound and the other of the sense oligomeric compounds forms a duplex region with the antisense oligomeric compound starting at the 3′-end of the antisense oligomeric compound, and the duplex regions are separate and non-overlapping and include each nucleoside of the antisense oligomeric compound; and the antisense oligomeric compound comprises from 20 to 24 linked nucleosides and each of the sense oligomeric compounds comprises from 10 to 12 linked nucleosides.