Patent ID: 7122649

Claim:
A compound comprising a plurality of linked nucleosides including a plurality of 2′-deoxy′-2′-fluoro, 2′-O—C 1 –C 20 -alkyl, 2′-O—C 2 –C 20 -alkenyl, 2′-O—C 2 –C 20 -alkynyl, 2′-S—C 1 –C 20 -alkyl, 2′-S—C 2 –C 20 -alkenyl, 2′-S—C 2 –C 20 -alkynyl, 2′-NH—C 1 –C 20 -alkyl, 2′-NH—C 2 –C 20 -alkenyl or 2′-NH—C 2 –C 20 -alkynyl nucleosides; and a 5′-O-terminal nucleoside having a conjugate group linked via a linker to the 5′-O-position of the nucleoside, provided that the compound does not include sulfamate or sulfamide internucleotide linkages.