Patent ID: 7202221

Claim:
A compound of formula (I) wherein A is a bivalent radical selected from: —C(O)—, —C(O)NH—, —NHC(O)—, —N(CH 3 )—CH 2 —, —CH 2 —N(CH 3 )— and —C(NOCH 2 OCH 2 CH 2 OCH 3 )—; R 1 is OC(O)(CH 2 ) n XR 7 ; R 2 is hydrogen or a hydroxyl protecting group; R 3 is hydrogen, C 1-4 alkyl or C 3-6 alkenyl optionally substituted by 9 to 10 membered fused bicyclic heteroaryl; R 4 is hydroxy or C 3-6 alkenyloxy optionally substituted by 9 to 10 membered fused bicyclic heteroaryl; R 5 is hydroxy or R 4 and R 5 taken together with the intervening atoms form a cyclic group having the following structure: wherein Y is a bivalent radical selected from: —CH 2 —, —CH(CN)—, —O—, —N(R 8 )— and —CH(SR 8 )—; R 6 is hydrogen or fluorine; R 7 is a heterocyclic group selected from: R 8 is hydrogen or C 1-4 alkyl substituted by a group selected from: optionally substituted phenyl, optionally substituted 5 or 6 membered heteroaryl, and optionally substituted 9 to 10 membered fused bicyclic heteroaryl; R 9 is hydrogen, C(O)OR 12 , C(O)NHR 12 or C(O)CH 2 NO 2 ; R 10 is hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, optionally substituted phenyl or benzyl; R 11 is halogen, C 1-4 alkyl, C 1-4 thioalkyl, C 1-4 alkoxy, NH 2 , NH(C 1-4 alkyl) or N(C 1-4 alkyl) 2 ; R 12 is hydrogen or C 1-4 alkyl; R 13 is hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, optionally substituted phenyl or benzyl, acetyl or benzoyl; X is —U(CH 2 ) m Z- or X is a group selected from: U and Z independently are a divalent radical selected from: —N(R 13 )—, —O—, —S(O)q-, —N(R 13 )C(O)—, —C(O)N(R 13 )—, and —N[C(O)R 13 ]—, W is a carbon or a nitrogen atom; n is 0 or an integer from 1 to 5; m is an integer from 2 to 8; p is 0, 1 or 2; q is 0, 1 or 2; or a pharmaceutically acceptable salt or solvate thereof.