Patent ID: 7700584

Claim:
A compound or a pharmaceutically acceptable salt thereof, wherein said compound comprising: a curcumol molecule modified by chemical groups Y or R 1 as shown in formula I: wherein, the chemical group R 1 is selected from the group consisting of R, RCO, HO 3 S, acyl of coffeic acid, gambogic acid, isogambogic acid, neogambogic acid and glycyrrhizic acid; Y is selected from the group consisting of Y 1 NY 2 , Y 1 CONY 2 , ═CHR 2 , —CH 2 R 2 , —OH and —OR, wherein Y 1 is H or C 1-8 , Y 2 is a C 1-8 heterocycle selected from the group consisting of wherein P is S, O or N, Z is selected from the group consisting of H, hydroxy group, saturated or unsaturated linear C 1-6 hydrocarbon group, saturated or unsaturated branched C 3-6 hydrocarbon group, n=1-3, R is selected from the group consisting of H, saturated or unsaturated linear C 1-10 hydrocarbon group, saturated or unsaturated branched C 3-10 hydrocarbon group, C 3-10 hydrocarbon ether, C 3-10 hydrocarbon sulfide, saturated or unsaturated C 3-8 cyclic hydrocarbon group optically substituted by at least one substituent selected from the group consisting of nitro, sulfonic acid group, halogen atom, hydroxyl group and C 6-12 aryl group, R 2 is selected from the group consisting of F, Cl, Br, I, —OH, —OR, —HSO 3 , —NO 3 , RNH—, R′NR″, pyridyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, dioxazolyl, dioxadiazolyl, piperidyl, wherein, R′ is selected from the group consisting of H, saturated or unsaturated linear C 1-10 hydrocarbon group, saturated or unsaturated branched C 3-10 hydrocarbon group, C 3-10 hydrocarbon ether, C 3-10 hydrocarbon sulfide, saturated or unsaturated C 3-8 cyclic hydrocarbon group optically substituted by at least one substituent selected from the group consisting of nitro, sulfonic acid group, halogen atom, hydroxyl group, C 6-12 aryl group and H 2 NRNH, R″ is selected from the group consisting of H, saturated or unsaturated linear C 1-10 hydrocarbon group, saturated or unsaturated branched C 3-10 hydrocarbon group, C 3-10 hydrocarbon ether, C 3-10 hydrocarbon sulfide, saturated or unsaturated C 3-8 cyclic hydrocarbon group optically substituted by at least one substituent selected from the group consisting of nitro, sulfonic acid group, halogen atom, hydroxyl group, C 6-12 aryl group and H 2 NRNH.