Patent ID: 8058512

Claim:
A method for producing a bioactive recombinant Transforming Growth Factor-Î² (TGF-Î²) protein in vivo in a plant host system, comprising transforming said plant host system with a chimeric nucleic acid sequence that encodes a TGF-Î² protein wherein said chimeric nucleic acid sequence comprises a first nucleic acid sequence that regulates transcription in said plant host system, a second nucleic acid sequence encoding a signal sequence and a third nucleic acid sequence encoding a full length bioactive TGF-Î² protein or a bioactive TGF-Î² protein C-terminal fragment; cultivating the transformed plant host system under conditions to express said bioactive TGF-Î² protein in vivo; and recovering said in vivo expressed bioactive TGF-Î² protein from said transformed plant host system.