Patent ID: 7572811

Claim:
A compound of Formula I: in which: n is chosen from 0 and 1 and; m is chosen from 1 and 2; R 1 is chosen from C 6-10 aryl and C 5-10 heteroaryl; wherein any aryl or heteroaryl of R 1 is optionally substituted by a radical chosen from C 6-10 arylC 0-4 alkyl, C 5-6 heteroarylC 0-4 alkyl, C 3-8 cycloalkylC 0-4 alkyl, C 3-8 heterocycloalkylC 0-4 alkyl or C 1-10 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl group of R 1 can be optionally substituted by 1 to 5 radicals chosen from halo, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted-C 1-10 alkyl and halo-substituted-C 1-10 alkoxy; and any alkyl group of R 1 can optionally have a methylene replaced by an atom or group chosen from —S—, —S(O)—, —S(O) 2 —, —NR 7 — and —O—; wherein R 7 is chosen from hydrogen and C 1-6 alkyl; R 2 , R 3 , R 4 and R 5 are independently chosen from hydrogen, halo, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted-C 1-10 alkyl and halo-substituted-C 1-10 alkoxy; A is chosen from —X 1 C(O)OR 7 , —X 1 OP(O)(OR 7 ) 2 , —X 1 P(O)(OR 7 ) 2 , —X 1 P(O)OR 7 , —X 1 S(O) 2 OR 7 and —X 1 P(O)(R 7 )OR 7 ; wherein X 1 is chosen from C 1-3 alkylene and C 2-3 alkenylene and R 7 is chosen from hydrogen and C 1-6 alkyl; B is CR 8 R 9 ; wherein R 8 and R 9 are independently chosen from hydrogen, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted-C 1-10 alkyl and halo-substituted-C 1-10 alkoxy; E is chosen from CR 8 or N; wherein R 8 is chosen from hydrogen, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted-C 1-10 alkyl and halo-substituted-C 1-10 alkoxy; or B is CR 9 and E is carbon and B and E are connected via a double bond; X is a bond or is chosen from —CH 2 O—, —OCH 2 —, —CH 2 S—, and C 4-6 heteroarylene; R 7 is chosen from hydrogen and C 1-6 alkyl; and any heteroarylene of X is optionally substituted by a member of the group chosen from halo and C 1-6 alkyl; Y is chosen from C 6-10 aryl and C 5-10 heteroaryl, wherein any aryl or heteroaryl of Y can be optionally substituted with 1 to 3 radicals chosen from halo, hydroxy, nitro, C 1-10 alkyl, C 1-10 alkoxy, halo-substituted C 1-10 alkyl and halo-substituted C 1-10 alkoxy; and the pharmaceutically acceptable salts, hydrates, and prodrugs thereof.