Patent ID: 7732482

Claim:
A method of treating fibrosis in a mammal, wherein the fibrosis is mediated by TGF-β, the method comprising administering to the mammal a compound having the formula wherein X is N or O; R 1 is H, hydroxyl, C 1-10 alkyloxy, C 2-10 alkenyloxy, which is unsubstituted or substituted with C 1-6 alkyl, or C 2-10 alkynyloxy; R 2 is H, hydroxyl, C 1-10 alkyl, C 2-10 alkenyl or C 2-10 alkynyl; R 3 is C 1-10 alkyl, C 2-10 alkenyl or C 2-10 alkynyl; denotes a single or double bond; provided that if X is O, R 3 is absent; if denotes a single bond, the compound has the formula: or a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof.