Patent ID: 8889682

Claim:
A compound of Formula I, wherein: is either a single or double bond; each X is independently CH, CH 2 , CHX′, or N; X′ is lower alkyl; R is H, —R 1 , —R 1 —R 2 —R 3 , —R 1 —R 3 ,or —R 2 —R 3 ; R 1 is aryl, heteroaryl, bicyclic heteroaryl, cycloalkyl, heterocycloalkyl, or bicyclic heterocycle, each of which is optionally substituted with one or more lower alkyl, hydroxy, hydroxy lower alkyl, lower alkoxy, halo, nitro, amino, amido, cyano, oxo, or lower haloalkyl; R 2 is —C(═O), —C(═O)O, —C(═O)NR 2′ , —NHC(═O)O, —C(R 2′ ) 2 , —O, —S, —C(═NH)NR 2′ , or —S(═O) 2 ; each R 2′ is independently H or lower alkyl; R 3 is H or R 4 ; R 4 is lower alkyl, lower haloalkyl, lower alkoxy, amino, lower alkyl amino, cycloalkyl amino, lower dialkyl amino, aryl, arylalkyl, alkylaryl, heteroaryl, lower alkyl heteroaryl, heteroaryl lower alkyl, cycloalkyl, lower alkyl cycloalkyl, cycloalkyl lower alkyl, heterocycloalkyl, lower alkyl heterocycloalkyl, heterocycloalkyl lower alkyl, bicyclic cycloalkyl, bicyclic heterocycloalkyl, spirocycloalkyl, spiroheterocycloalkyl, or bicyclic spiroheterocycloalkyl, each of which is optionally substituted with one or more lower alkyl, halo, lower alkyl amino, lower dialkyl amino, hydroxy, hydroxy lower alkyl, lower alkoxy, lower alkanoyl, halo, nitro, amino, amido, acyl, cyano, oxo, sulfonyl, lower alkyl sulfonyl, guanidino, hydroxyl amino, carboxy, carbamoyl, carbamate, halo lower alkoxy, heterocycloalkyl, or halo lower alkyl, wherein two lower alkyl groups may together form a ring; each of A, Y, and Y 1 is CH or N, with the proviso that at least one of A, Y, and Y 1 must be N; Y 2 is CH or N; Y 3 is H or F; Y 4 is Y 4a , Y 4b , Y 4c , or Y 4d ; Y 4a is H or halogen; Y 4b is lower alkyl, optionally substituted with one or more substituents selected from the group consisting of lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy; Y 4c is lower cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy; and Y 4d is amino, optionally substituted with one or more lower alkyl, alkoxy lower alkyl, or hydroxy lower alkyl; or a pharmaceutically acceptable salt thereof.