Patent ID: 7071175

Claim:
A compound of Formula I or a pharmaceutically acceptable salt or solvate thereof, or a solvate of such a salt, wherein: R 1 is pyridyl substituted with one or more basic groups; R 2 is selected from the group consisting of H, acyl, acylamino, alkyl, alkylcarbamoyl, alkylthio, alkoxy, aroyl, aroylamino, aryloxy, arylthio, amidino, amino, aryl, carbamoyl, carboxy, cyano, cycloalkyl, formyl, guanidino, halogen, heterocyclyl, hydroxy, oxo, nitro, thiol, a Z 2 N—CO—O— group, a ZO—CO—NZ— group, and a Z 2 N—CO—NZ— group; R 3 is selected from the group consisting of COOR 5 , SO(OR 5 ), SO 3 R 5 , P═O(OR 5 ) 2 , B(OR 5 ) 2 , P═OR 5 (OR 5 ), tetrazole, and a carboxylic acid isostere which is an acidic group having a pKa of from about −5 to about 25; R 4 is SH, S—CO—C 1 -C 6 alkyl, or S—CO-aryl; R 5 is H, C 1 -C 6 alkyl, or aryl; R 6 is H or C 1 -C 6 alkyl; X is selected from the group consisting of O, S, SO, SO 2 , C(Z) 2 , N (Z), NR 6 SO 2 , SO 2 NR 6 , NR 6 CO, and CONR 6 ; Y is C(Z) 2 ; and Z is independently selected from the group consisting of H, C 1 -C 6 alkyl, aryl, cycloalkyl, and heterocyclyl.