Patent ID: 8309307

Claim:
A method comprising: a) contacting a target nucleic acid with a solution to produce a hybridized sample, said solution comprising a mixture of at least 5 different labeled oligonucleotides that specifically bind to a region in a mammalian chromosome, wherein said labeled oligonucleotides: i. are complementary to a unique sequence in said region; ii. are of 80 to 200 nucleotides in length; and iii. include a labeled oligonucleotide comprising a nucleotide sequence that overlaps with a nucleotide sequence in another labeled oligonucleotide in said mixture, wherein said labeled oligonucleotides, when hybridized to said mammalian chromosome, are tiled across said region; and b) imaging said hybridized sample to a provide a binding pattern for said labeled oligonucleotides.