Patent ID: 7405233

Claim:
A method of modulating premature translation termination and/or nonsense-mediated mRNA decay in a cell in vitro, comprising contacting a cell exhibiting premature translation termination and/or nonsense-mediated mRNA decay with an effective amount of a compound having the structure: or a pharmaceutically acceptable salt, hydrate, clathrate or stereoisomer thereof, wherein: X is C(═O), C(═S), S, S(═O) or S(O) 2 ; Y is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted cycloalkyl; R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, or substituted or unsubstituted cycloalkylalkyl; n is an integer ranging from 0-4; R 1 and R 2 together form: and R 3 -R 6 are each independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted cycloalkylalkyl, or alkoxy.