Patent ID: 7825147

Claim:
A compound having the structure of Formula I, and its pharmaceutically acceptable salts, wherein X is O Y is O Y 1 , Y 2 , R 7 and R 4 are H; X 1 and X 2 are independently selected from the group consisting of hydrogen, an alkyl group having 1 to 5 carbon atoms, wherein one or more of the hydrogen atoms of the alkyl group may be substituted with a halo, aryl, cycloalkyl, or heterocyclyl group, and a cycloalkyl group having 5 to 9 carbon atoms; R 1 is an alkyl group of 1-2 carbon atoms, or —CH 2 —CO—R p wherein R f is an optionally substituted 5- to 7-membered heterocyclyl ring having 1 to 2 nitrogen atoms, wherein the substituents are selected from the group consisting of alkyl, —CO-alkyl, —COOalkyl, aralkyl, aryl, and hydroxyalkyl groups R 2 is substituted —COR p — wherein R p is an optionally substituted 5- to 7-membered heterocyclyl ring having 1 or 2 nitrogen atoms, wherein the substituents are selected from the group consisting of alkyl, —CO-alkyl, —COOH, heterocyclyl, oxo, —COOalkyl, —CONH 2 , —CONH-alkyl, —CON(alkyl) 2 , (3-aryl-5-alkyl-4,5-dihydro-isoxazol-5-yl)-methanonyl, hydroxyl, aralkyl, aryl, wherein the alkyl or aryl groups may be further substituted with hydroxyl, cycloalkyl or halo groups, with the proviso that when the substituent is (3-aryl-5-alkyl-4,5-dihydro-isoxazol-5-yl)-methanonyl group, R p is a 1,4-diazepan ring and the substitution is on the nitrogen atom, Alternatively, R 1 and R 2 may together form an optionally substituted cycloalkyl ring having 4 to 9 carbons, wherein the substituents are selected from the group consisting of oxo, NH 2 , NH—COO-alkyl, —N—(COO-alkyl) 2 , and phthalimido groups, or an optionally substituted 5- to 6-membered heterocyclyl ring having 1 to 2 oxygen or nitrogen atoms, wherein the substituents are selected from the group consisting of alkyl, oxo, NH 2 , COOalkyl, —CONH—SO 2 -aryl and CO—NH-aryl, with the proviso that that the heterocyclyl ring is not a dihydrofuran ring.