Patent ID: 7427488

Claim:
A method of screening candidate substances for an ability to modulate phosphatidylserine exposure on the surface of a platelet, the method comprising: (a) providing a test sample comprising a platelet voltage dependent calcium channel (VDCC) comprising a VDCCα1 subunit polypeptide on the surface of a platelet, wherein said VDCCα1 subunit polypeptide is selected from the group consisting of SEQ ID NO: 2 or SEQ ID NO: 4, (b) administering a candidate substance to the test sample, and (c) measuring the effect of said candidate substance on phosphatidylserine exposure on the surface of the platelet by determining a first level of phosphatidylserine exposure on the surface of the platelet before the administering step (b); determining a second level of phosphatidylserine exposure on the surface of the platelet after the administering step (b); and comparing the first level and the second level, wherein a difference between the first level and the second level indicates the ability of the candidate substance to modulate phosphatidylserine exposure on the surface of a platelet.