Patent ID: 7790747

Claim:
A compound having the formula 1: and pharmaceutically acceptable salts thereof, wherein A is carbon or sulfur; X is oxygen, sulfur, NR 2 , NOR 2 , NCN, NSO 2 R 2 , NAc, NNO 2 , CRNO 2 , NCOR 2 , C(CN) 2 or CRCN, provided X is oxygen if A is sulfur; Y is a bond, O(CR 2 ) p , S(CR 2 ) p , NR(CR 2 ) p or (CR 2 ) p wherein one carbon in (CR 2 ) p may optionally be substituted and/or replaced with N, O or S; n and p are independently 0 to 6; m is 1 to 2, provided m is 1 if A is carbon; E is H or methyl; R 1 is an optionally substituted aryl or heteroaryl; R 2 is H, an optionally substituted alkyl, a carbocyclic ring, a heterocyclic ring, an aryl, or a heteroaryl; and R 3 is H; an optionally substituted alkyl, alkenyl or alkynyl; hydroxy, alkoxy, cyano, amino, amido, carboxyl, CO 2 R 2 , S═(O) p R 2 , CR═N—OR, O(CR 2 )CN, NR—COR 2 , SR 2 ; a carbocyclic ring, a heterocyclic ring, an aryl, or a heteroaryl; R and R 4 are independently H, C 1-6 alkyl, or C 3-6 cycloalkyl; wherein in each said optionally substituted alkyl, alkenyl or alkynyl, a carbon may be optionally substituted with halo, N, O, or S, and/or replaced with N, O or S; and each carbocyclic ring, heterocyclic ring, aryl or heteroaryl may be optionally substituted and/or fused with a carbocyclic, aryl, heterocyclic, or heteroaryl ring.