Patent ID: 6984634

Claim:
A compound of formula (I): wherein: R 1 and R 2 are independently hydrogen or hydroxy; X is hydroxy; Z is a group of formula -M-Q x′ , wherein M is —CH 2 CH 2 C(O)—, and wherein Q x′ is of the following structure: —[NR 50′ —(CR 51′ R 52′ ) a′ —(CR 53′ R 54′ ) b′ —C(O)]—D′—OH wherein a′ and b′ are independently 0 or 1, wherein at least one of a′ and b′ is 1; R 50′ is hydrogen or R 50′ and R 51′ together with the atoms to which they are attached form a heterocyclyl ring; R 51′ is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl or R 51′ and R 52′ together with the atoms to which they are attached form a cycloalkyl, substituted cycloalkyl, heterocyclyl or substituted heterocyclyl ring, or R 51′ and R 53′ together with the atoms to which they are attached form a cycloalkyl, substituted cycloalkyl, heterocyclyl or substituted heterocyclyl ring; R 52′ is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 53′ is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl or R 53′ and R 54′ together with the atoms to which they are attached form a cycloalkyl, substituted cycloalkyl, heterocyclyl or substituted heterocyclyl ring; R 54′ is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; and D′ is a pharmacologically active chemical compound containing at least one carboxylic acid group and at least one moiety selected from the group consisting of a primary amino group, a secondary amino group or a hydroxyl group; with the provisos that D′ is not a GABA analog; L-Dopa, an L-aromatic amino acid decarboxylase inhibitor, a catechol O-methyl transferase inhibitor or derivatives thereof; a naturally occuring α-amino acid or an ester or carboxamide of a naturally occuring α-amino acid; a polypeptide derived from a linear oligopeptide containing at least 3 α-amino acids; an oligonucleotide; a cyclophane derivative, a diethylenetriaminopentaacetate derivative, or paramagnetic ion chelates thereof; 5-de-O-methylsporaricin; a bis-(2-choroethyl)amino containing nitrogen mustard; an HMG-CoA reductase inhibitor; a proline hydroxylase inhibitor; or a steriod containing the carbon substructures of the following formulae; or a pharmaceutically acceptable salt thereof.