Patent ID: 8343976

Claim:
A compound of formula Ia or Ib: wherein p is 1, 2, or 3; R 1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryloxy and substituted aryloxy; R 2 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl; R 3 and R 4 are each independently halo; R 5 is selected from the group consisting of hydrogen, hydroxyl, alkoxy, and substituted alkoxy; R 6 is selected from the group consisting of hydrogen, alkyl and substituted alkyl; and R 8 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, and substituted alkoxy; or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof; wherein said compound exhibits at least one of the following: a) an IC 50 of less than 30 μM in the T84 assay; b) a greater than 30% inhibition at 20 μM in the FRT assay; or c) a greater than 35% inhibition at 50 μM in a T84 assay, provided that the compound does not have an IC 50 greater than 30 μM.