Patent ID: 7167801

Claim:
A method of identifying a potential inhibitor of a Human Papillomavirus (HPV) E2-protein comprising a deep cavity binding pocket, wherein said HPV E2-protein is selected from the group consisting of: HPV-6, HPV-11, HPV-16 and HPV-18, said method comprising the steps of: (a) using the atomic coordinates of FIG. 9 to generate a three-dimensional model; (b) identifying said binding pocket residues which comprises at least residues His-32, Trp-33 and Leu-94, and using said residues to generate a specific three-dimensional (3-D) target; (c) employing said 3-D target of (b) to design or select said potential inhibitor; (d) synthesizing said potential inhibitor; and (e) contacting said potential inhibitor with said HPV E2 protein in vitro to determine the ability of said potential inhibitor to interact with said HPV E2 protein; whereby the ability to interact is an indication that said potential inhibitor of said HPV E2 protein is identified.