Patent ID: 7431942

Claim:
An orally disintegrable tablet which comprises (i) fine granules having an average particle diameter of 300 to 400 μm, which fine granules comprise: (a) a core composition comprising excipient and 10 weight % or more of an acid-labile physiologically active substance, (b) an enteric coating layer for the core composition comprising a first component that is an enteric coating agent and a second component that is a sustained-release agent, and (c) a coating layer comprising mannitol outside the enteric coating layer; and (ii) a water-soluble sugar alcohol, wherein said water-soluble sugar alcohol is comprised in the tablet separately from said fine granules (i) in said tablet and wherein the water-soluble sugar alcohol separate from said fine granules is in an amount of 5 to 97 weight % relative to 100 weight % of the orally disintegrable tablet apart from the fine granules; wherein said tablet having a hardness strength of about 1 to about 20 kg is orally disintegrable; and wherein the oral disintegration time for complete disintegration of said tablet is one minute or less.