Patent ID: 8722858

Claim:
A pharmaceutical composition comprising as an active agent an antibody which binds to Prominin-1, wherein the antibody is not bound to a cytotoxic substance, wherein the antibody comprises the amino acid sequence of SEQ ID NO: 12 as a heavy chain variable region CDR1, the amino acid sequence of SEQ ID NO: 14 as a heavy chain variable region CDR2, and the amino acid sequence of SEQ ID NO: 16 as a heavy chain variable region CDR3, and comprises as a light chain variable region the amino acid sequence of position 1 to 112 of SEQ ID NO: 34 wherein the amino acid which corresponds to position 15 in the amino acid sequence of SEQ ID NO: 34 is Phe, and wherein the antibody is a chimeric antibody or humanized antibody comprising a heavy chain constant region of a human IgG1 antibody and a light chain constant region of a human κ chain, and has ADCC activity.