Patent ID: 7122516

Claim:
A method for making a protease resistant bioactive peptide comprising: attaching a first stabilizing group to the N-terminus of a bioactive peptide; and attaching a second stabilizing group to the C-terminus of the bioactive peptide to yield the protease resistant bioactive peptide; wherein the first stabilizing group is selected from the group consisting of a small stable protein selected from the group consisting of Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, and glutathione reductase, Pro-, Pro-pro-, Xaa-Pro- and Xaa-Pro-Pro-, and wherein the second stabilizing group is selected from the group consisting of a small stable protein selected from the group consisting of Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, and glutathione reductase, -Pro, -Pro-Pro, -Pro-Xaa and -Pro-Pro-Xaa, wherein Xaa is any amino acid residue.