Patent ID: 8524697

Claim:
A compound, or a pharmaceutically acceptable salt, ester, or isomer thereof, of Formula (IV): wherein L, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are selected independently of each other and wherein: L is —CH 2 —S—; R 1 is a benzofused heteroaryl-, wherein said R 1 group is unsubstituted or optionally substituted with from 1 to 5 substituents, which may be the same or different, each independently selected from halogen, hydroxy, —CN, oxo, oxide, alkyl, haloalkyl, haloalkoxy-, hydroxyalkyl-, heteroalkyl, cyanoalkyl-, alkoxy, optionally substituted aryl, optionally substituted —O-aryl, optionally substituted —O-alkyl-aryl, optionally substituted heteroaryl, optionally substituted arylalkyl-, optionally substituted arylalkoxy, —N(R 7 ) 2 , -alkylN(R 7 ) 2 , —NC(O)R 7 , —CO 2 R 7 , —SO 2 R 7 , and —SO 2 N(R 7 ) 2 , wherein said optional substituents are present from 1 to 4 times and may be the same or different, each independently selected from alkyl, halogen, haloalkyl, hydroxyl, —CN, and —N(R 11 ) 2 ; and wherein the benzo portion of each said benzofused R 1 group is optionally further fused to another ring selected from heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, and heterocycloalkenyl, R 2 is —OR 8 ; R 3 is selected from hydrogen, hydroxy, and straight or branched alkyl, R 4 is selected from H and halogen; R 5 is selected from H, halogen, and alkyl; z (the dotted line) represents a single or double bond, with the proviso that when z is a single bond, R 6 is H; R 6 is selected from H and halogen; each R 7 is independently selected from hydrogen, alkyl, haloalkyl, aryl, and heteroaryl, or, when two groups R 7 are attached to the same nitrogen atom, two groups R 7 are taken together with the nitrogen atom to which they are attached to form a 3- to 7-membered heterocycloalkyl group; R 8 selected from haloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, —C(O)NHR 9 , and —C(O)R 11 ; R 9 is selected from alkyl, haloalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each unsubstituted or optionally substituted with from 1 to 4 substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, hydroxy, —N(R 7 ) 2 , and —CN; R 10 is selected from hydrogen and alkyl; and R 11 is selected from haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, and heterocycloalkenyl, each unsubstituted or optionally substituted with from 1 to 4 substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, hydroxy, —N(R 7 ) 2 , and —CN.