Patent ID: 7393994

Claim:
A transgenic mouse comprising: a first transgenic nucleotide sequence, integrated into the genome of said mouse, comprising a sequence encoding the wild-type human amyloid precursor protein (hAPP) 751 amino acid isoform (hAPP751) operably linked to a first promoter; and a second transgenic nucleotide sequence, integrated into the genome of said mouse, comprising a sequence encoding the wild-type human (h) α-synuclein operably linked to a second promoter; wherein the first and second transgenic nucleotide sequences are expressed, the first and the second promoter are neuron-active promoters, and as a result of expression of the hAPP751 and (h) α-synuclein, said transgenic mouse develops amyloidosis, neurofibrillary tangles and intraneuronal accumulation of (h) α-synuclein.