Patent ID: 7807382

Claim:
A method for identifying agonists or antagonists of the interaction of endosialin with a ligand for endosialin, said ligand for endosialin comprising collagen I, collagen IV, fibronectin, the 70 kDa N-terminal fragment of fibronectin, the 45 kDa gelatin binding fragment of fibronectin, or the 30 kDa heparin binding fragment of fibronectin, said method comprising contacting endosialin with said ligand for endosialin in the presence and absence of a test compound and quantifiably measuring the interaction of endosialin with the ligand, wherein an increase or a decrease in the level of interaction of endosialin with said ligand in the presence of the test compound indicates that the test compound is an agonist or antagonist, respectively, of the interaction of endosialin with said ligand.