Patent ID: 8455520

Claim:
A compound represented by formula I: or a pharmaceutically acceptable salt thereof wherein: ring B is selected from the group consisting of: phenyl, pyridyl, pyrazolyl, thiadiazolyl, benzisoxazolyl, benzthiazolyl; benzopyrazinyl; pyrimidinyl, thiazolyl, oxadiazolyl, triazolyl, tetrazolyl and tetrahydronaphthyl; each R a is defined as follows: a) each R a is H or halo, or b) 1-2 R a groups represent H or halo, 0-1 R a represents Aryl, HAR or Hetcy, each of which being optionally substituted with 1-3 halo, C 1-3 alkyl or haloC 1-3 alkyl groups, and 0-1 members selected from —C 1-3 alkyl-Aryl and —CO 2 —C 1-6 alkyl; and any remaining R a groups are selected from the group consisting of: C 1-3 alkyl, OC 1-3 alkyl, haloC 1-3 alkyl, OhaloC 1-3 alkyl, S(O) x C 1-3 alkyl, S(O) x -haloC 1-3 alkyl, S(O) x Aryl wherein x is 0, 1 or 2, CO 2 R b and C 1-3 alkyl-CO 2 R b , wherein R b is H, C 1-4 alkyl, haloC 1-4 alkyl, Aryl, HAR or Hetcy; R 1 is selected from the group consisting of: a) CO 2 R d in which R d represents H, C 1-3 alkyl-R e , Aryl, HAR or Hetcy, wherein R e is selected from the group consisting of: H, OC 1-3 alkyl, halo, OhaloC 1-3 alkyl, S(O) x C 1-3 alkyl, S(O) x haloC 1-3 alkyl, Aryl, HAR, Hetcy, S(O) X -Aryl and CO 2 R b ; b) halo or CN; c) C 1-6 alkyl or OC 1-6 alkyl, each optionally substituted with up to 3 halo groups, and a member selected from the group consisting of: i) CN, C(O)NH 2 , C(O)NHCH 3 or C(O)N(CH 3 ) 2 ; ii) CO 2 R d with R d as previously defined in a) above; iii) OH, OC 1-3 alkyl, haloOC 1-3 alkyl, NH 2 , NHCH 3 or N(CH 3 ) 2 ; and iv) Aryl or HAR, each being optionally substituted with 1-3 halo, C 1-3 alkyl or haloC 1-3 alkyl groups, and 0-1 members selected from —C 1-3 alkyl-Aryl and —CO 2 —C 1-6 alkyl; and d) Aryl or HAR, each optionally substituted with 1-2 halo, C 1-3 alkyl, haloC 1-3 alkyl, OC 1-3 alkyl, OhaloC 1-3 alkyl or Aryl(R a ) 3 groups and 0-1 members selected from the group consisting of: CN, HAR(R a ) 3 , CO 2 C 1-6 alkyl, CO 2 H, C(O)N(R f ) 2 , NHC(O)N(R f ) 2 and NHC(O)OR g wherein each R f is H or C 1-6 alkyl and each R g represents C 1-3 alkyl, haloC 1-3 alkyl, Aryl, HAR or Hetcy; R 2 is selected from the group consisting of: —(CR h 2 ) 0-2 —Y—(CR h 2 ) 0-2 -Aryl(R a ) 3 , and —(CR h 2 ) 0-2 —Y—(CR h 2 ) 0-2 —HAR(R a ) 3 , wherein Y represents a bond, CH 2 , O, S(O) x , C(O)NR f , NR f C(O), C(O) or NR f C(O)O; x, and R f are as previously defined and R h represents a member selected from the group consisting of: H, C 1-3 alkyl, OC 1-3 alkyl and halo; and each R 3 is selected from the group consisting of: H, halo, C 1-3 alkyl, OC 1-3 alkyl, haloC 1-3 alkyl and OhaloC 1-3 alkyl, or one R 3 group is selected from d) above, and the other two R 3 groups represent H, halo, C 1-3 alkyl, OC 1-3 alkyl, haloC 1-3 alkyl, OhaloC 1-3 alkyl, CO 2 R b or C(O)NHR b .