Patent ID: 7429492

Claim:
A multiwell plate comprising: (a) a colorimetric resonant reflectance biosensor or a grating-based waveguide biosensor; (b) a first liquid impermeable sheet of a thickness of about 5 μm to about 1,000 μm, wherein the first liquid impermeable sheet has two or more holes; wherein the first liquid impermeable sheet is attached to a top surface of the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor; (c) a membrane attached to the top of the first liquid impermeable sheet, wherein the membrane covers all of the holes of the first liquid impermeable sheet; (d) a multiwell plate frame attached to the top of the membrane, wherein the multiwell plate frame has two or more holes and wherein the holes have a same size, number, and position as in the first liquid impermeable sheet such that a multiwell plate with an upper chamber and a lower chamber is formed by the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor, the first liquid impermeable sheet, the membrane, and the multiwell plate frame.