Patent ID: 6924290

Claim:
A compound of formula I: wherein R 1 and R 2 are each independently H, halo, alkyl optionally substituted by halo up to perhalo, cycloalkyl, alkenyl, alkynyl, NO 2 , NH 2 , NR 6 R 7 , or furyl, thienyl, pyridyl, trifluoromethyl or phenyl each optionally substituted with NH 2 , NO 2 , trifluoromethyl or alkoxy; or R 1 and R 2 may be taken together to form a ring of from 5 to 7 members optionally interrupted by N and optionally substituted on N by benzyl; R 3 is NH 2 or —NH-phenyl optionally substituted with halo, C 1 -C 4 alkyl, trifluoromethyl, nitro or amino; R 4 is or indol-5-yl (optionally) substituted on N with pyridyl; X is a linker substituted at the 3 or 4 position of the ring and is O, S, —S—CH 2 —, —(CH 2 )m—, or —(C═O)—; A is phenyl, phenyl substituted with alkylthio or OH, pyridyl, quinolyl or isoquinolyl; each R 5 independently is halo, alkyl optionally substituted by halo up to perhalo, cycloalkyl, alkoxy, alkenyl, alkynyl, NO 2 , NH 2 , or trifluoromethyl; n is 0, 1, 2, 3 or 4; m is 1 or 2; and R 6 and R 7 are each independently H, alkyl, cycloalkyl, or phenyl optionally substituted with halo, CF 3 , alkyl, nitro or amino; or R 6 and R 7 may form, together with the N atom to which they are attached, a heterocyclic ring optionally substituted with alkyl, optionally interrupted by O, or optionally fused to phenyl; or a pharmaceutically acceptable salt thereof, with the proviso that formula I does not include the following compounds: