Patent ID: 8426126

Claim:
A method of separating at least one polynucleotide from a solution containing the polynucleotide, comprising: admixing magnetic particles having at least one surface comprising a dextran and the solution containing at least one polynucleotide to produce an admixture, wherein the dextran comprises plain dextran or dextran sulfonate; adjusting a salt concentration and an organic solvent concentration of the admixture to concentrations wherein the at least one polynucleotide binds to the at least one surface to produce a modified surface wherein the organic solvent concentration is a concentration of one or more organic solvents comprising at least one of methanol, ethanol, propanol, isopropanol, butanol, pentanol, a dimethyl sulfoxide, and acetone; separating the at least one modified surface from the remainder of the admixture while the at least one polynucleotide is bound to the surface; and contacting the modified surface with an elution buffer, thereby separating the at least one polynucleotide from the at least one surface.