Patent ID: 8486964

Claim:
A fused pyrrolidino-cyclopropane compound according to formula (III) or formula (IV) wherein: R 1 , R 2 are independently from each other H, Z, or aryl, or R 1 and R 2 , together with W to which they are attached, form a C 1 -C 4 -cycloalkyl ring which is optionally substituted with one or more substituents Z; R 3 , R 4 are independently from each other H or Z, or R 3 and R 4 form together with the carbon atom to which they are attached to C═O, or R 3 and R 4 , together with the carbon atom to which they are attached, form a C 1 -C 4 -cycloalkyl ring which is optionally substituted with one or more substituents Z; R 5 , R 6 are independently from each other H or Z; R 7 is H or Z; R 4 , R 5 optionally, form together with the carbon atoms to which they are attached to and the bond between them a C 1 -C 7 -cycloalkyl ring, which is optionally substituted with one or more substituents Z; W is (C) n ; X is absent or —O—, —S—, —S(O)— or —S(O) 2 —; Y is alkoxyalkyl, aryloxy, or aryl, which is optionally independently mono-, di- or trisubstituted with Z, C 1 -C 4 -alkyloxy, C 1 -C 4 -alkyloxycarbonyl, C 1 -C 4 -alkylcarbonyl, or R 8 R 9 NC 1 -C 4 -alkyloxy; Z is hydroxy, —SH, halogen, cyano, carboxy, carboxymethyl, carboxyethyl, haloalkyl, alkyl, cycloalkyl, haloalkoxy, alkoxy, NR 8 R 9 , azido, nitro, oxo, alkylthio, alkyl sulfonyl, or SF 5 ; R 8 , R 9 are independently from each other H, C 1 -C 4 -alkyl or C 4 -C 7 -cycloalkyl; R 10 represents one, two or three substituents on the pyrido ring, which are independently from each other H or Z; R 11 is H or Z; R 12 is H or Z; n is 0 or 1; with the proviso that if n is 0, X is not absent; or a physiologically acceptable salt, solvate or stereoisomer thereof.