Patent ID: 7105563

Claim:
A compound of formula (I): wherein: m is 0 to 4; n is 1 to 3; A is oxygen; R 1 is hydrogen, alkyl, —C(O)OR 7 , or —C(O)N(R 7 ) 2 ; or R 1 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, halo, haloalkyl, cyano, nitro, —R 8 —OR 7 , —R 8 —N(R 7 ) 2 , —R 8 —C(O)OR 7 , —R 8 —C(O)N(R 7 ) 2 , —R 8 —N(R 7 )C(O)N(R 7 ) 2 , —R 8 —N(R 7 )C(O)—R 9 —N(R 7 ) 2 and —R 8 —N(R 7 )C(O)OR 7 ); or R 1 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, halo, haloalkyl, cyano, nitro, —R 8 —OR 7 , —R 8 —N(R 7 ) 2 , —R 8 —C(O)OR 7 , —R 8 —C(O)N(R 7 ) 2 , —R 8 —N(R 7 )C(O)N(R 7 ) 2 , —R 8 —N(R 7 )C(O)—R 9 —N(R 7 ) 2 and —R 8 —N(R 7 )C(O)OR 7 ); each R 2 is independently selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, haloalkenyl, cyano, —R 8 —OR 7 , —R 8 —N(R 7 ) 2 , —R 8 —C(O)OR 7 , —R 8 —C(O)N(R 7 ) 2 , —R 8 —N(R 7 )S(O) t R 7 (where t is 1 or 2), —R 8 —N(R 7 )S(O) t N(R 7 ) 2 (where t is 1 or 2), —R 8 —N(R 7 )S(O) t N(R 7 )C(O)OR 7 (where t is 1 or 2), —R 8 —N(R 7 )C(O)R 7 , —R 8 —N(R 7 )—R 8 —C(O)OR 7 , —R 8 —N(R 7 )C(O)N(R 7 ) 2 , —R 8 —N(R 7 )C(O)—R 9 —N(R 7 ) 2 , —R 8 —N(R 7 )—R 9 —C(O)N(R 7 ) 2 , —R 8 —N(R 7 )C(O)—R 8 —N(R 7 )—R 8 —C(O)OR 7 , —R 8 —N(R 7 )C(O)—R 8 —N(R 7 )—R 8 —C(O)—R 8 —N(R 7 ) 2 , —N(R 7 )C(═NR 7 )N(R 7 ) 2 , —C(═NR 7 )—N(R 7 ) 2 , —R 8 —N═C(R 7 ) 2 , heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, halo, haloalkyl, cyano, nitro, —R 8 —OR 7 , —R 8 —C(O)OR 7 , —R 8 —C(O)N(R 7 ) 2 , —R 8 —N(R 7 ) 2 , —R 8 —N(R 7 )C(O)—R 8 —N(R 7 ) 2 and —R 8 —N(R 7 )C(O)OR 7 ), and optionally substituted cyclic ureido groups; R 3 is hydrogen, alkyl or aralkyl; R 5 is hydrogen, alkyl, aryl, aralkyl, —C(O)R 11 or —S(O) 2 R 11 ; each R 6 is optionally substituted phenyl; each R 7 is independently hydrogen, optionally substituted alkyl, haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, or optionally substituted heterocyclylalkyl; each R 8 is a bond or a straight or branched alkylene chain; each R 9 is a straight or branched alkylene chain; and each R 11 is optionally substituted alkyl, haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, or optionally substituted heterocyclylalkyl; as a single stereoisomer, a mixture of stereoisomers, a solvate or a polymorph; or a pharmaceutically acceptable salt thereof; with the following provisos: (1) when m is 2, n is 1, A is oxygen, R 1 , R 3 and R 5 are each hydrogen, R 6 is 3-methoxy, and one R 2 is 4-amino, the other R 2 can not be 5-amino; and (2) when m is 2, n is 1, A is oxygen, R 1 , R 3 and R 5 are each hydrogen, and R 6 is 3-methoxy, and one R 2 is 5-nitro, the other R 2 can not be 4-fluoro or 4-azido.