Patent ID: 8530621

Claim:
A chimeric peptide comprising: (a) a tryptophan (W) residue that binds to a pocket on the surface of talin molecule; (b) a membrane proximal (MP) peptide of β 3 integrin tail comprising the amino acid sequence KLLITIHDRKEFAKFEEERARAK (SEQ ID NO: 7), wherein at least one F residue is mutated, on the aminoterminal side of the tryptophan residue of (a); and (c) a C-terminal peptide PIPKIγ comprising the amino acid sequence VpYSPLHYSAR (SEQ ID NO: 8) on the carboxyl-terminal side of the tryptophan residue of (a) to form a binding site in conjunction with (a) and (b); wherein the chimeric peptide is soluble and has higher affinity for talin than β 3 integrin tail.