Patent ID: 8008049

Claim:
A DNA that is isolated and pure, and that contains at least one region encoding a polypeptide that participates in pladienolide biosynthesis, said DNA comprising at least one nucleotide sequence selected from the nucleotide sequences defined in any of the following (1) to (3): (1) nucleotide sequences defined in any of the following (a) to (g): (a) the continuous nucleotide sequence from the base 8340 to base 27935 of SEQ ID NO: 1; (b) the continuous nucleotide sequence from the base 28021 to base 49098 of SEQ ID NO: 1; (c) the continuous nucleotide sequence from the base 49134 to base 60269 of SEQ ID NO: 1; (d) the continuous nucleotide sequence from the base 60269 to base 65692 of SEQ ID NO: 1; (e) the continuous nucleotide sequence from the base 65707 to base 66903 of SEQ ID NO: 1; (f) the continuous nucleotide sequence from the base 68160 to base 66970 of SEQ ID NO: 1; (g) the continuous nucleotide sequence from the base 69568 to base 68270 of SEQ ID NO: 1; (2) a nucleotide sequence having at least 90% identity over the full length sequence with any of the nucleotide sequences defined in (1); (3) a DNA encoding SEQ ID NO:2-8.