Patent ID: 8440792

Claim:
An isolated antimicrobial peptide comprising: a peptide of from 13 to 18 amino acids containing a 12 amino acid core sequence: aa 1 -aa 2 -aa 3 -aa 4 -aa 5 -aa 6 -aa 7 -aa 8 -aa 9 -aa 10 -aa 11 -aa 12 , wherein aa 1 is the amino- terminus of the peptide and is selected from the group consisting of leucine, isoleucine, alanine, valine, serine, lysine and glycine; aa 2 is selected from the group consisting of leucine, isoleucine, alanine, valine, serine and arginine; aa 3 is selected from the group consisting of phenylalanine, tryptophan and tyrosine; aa 4 and aa 5 are selected from the group consisting of lysine, arginine and histidine; one of aa 6 and aa 7 is selected from the group consisting of phenylalanine, tryptophan and tyrosine, such that when aa 6 is phenylalanine aa 7 is selected from the group consisting of lysine, arginine and histidine, when aa 6 is tryptophan aa 7 is lysine, and when aa 7 is phenylalanine aa 6 is leucine; aa 8 is selected from the group consisting of lysine, arginine, histidine and asparagine; aa 9 is selected from the group consisting of lysine, arginine and histidine; aa 10 is selected from the group consisting of leucine, isoleucine, alanine, valine and serine; aa 11 is selected from the group consisting of leucine, isoleucine, alanine, valine, serine and lysine; and aa 12 is selected from the group consisting of lysine, arginine and histidine; and retromers, extensions, combinations, and fusions thereof, wherein said peptide has antimicrobial activity.