Patent ID: 7193081

Claim:
A method for the preparation of a compound of Formula I: comprising: (a) coupling 1-arylpropane-1,3-diol, wherein the aryl is a phenyl optionally substituted with 1–2 substituents selected from the group consisting of fluoro, chloro, and bromo, with MPOCl 2 substituted at the N-6 position with a nitrogen protecting group; and (b) removing the N-6 protecting group; wherein: M and V are cis to one another, MPO 3 H 2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine and (R)-9-(2-phosphonylmethoxypropyl)adenine; and V is phenyl, optionally substituted with 1–2 substituents selected from the group consisting of fluoro, chloro, and bromo.