Patent ID: 8729119

Claim:
A method of treating pulmonary arterial hypertension, comprising administering to a patient a therapeutically effective amount of a compound of formula I: where: X and Y are —CH—, or X is —CH— and Y is —N—, or X is —N— and Y is —CH—; R 1 is selected from —C 1-6 alkyl optionally substituted with 1 to 5 groups selected from halo, —NHC(O)CH 3 , and —C(O)NHCH 3 ; —C 3-6 cycloalkyl; —C 1-2 alkylene-OR; —C 1-2 alkylene-COOR; —C 0-3 alkylene-phenyl optionally substituted with —NHC(O)CH 3 or —C(O)NHCH 3 ; and —C 0-3 alkylene-pyridyl; where R is selected from hydrogen and —C 1-3 alkyl; R 2 is selected from hydrogen, —C 1-6 alkyl, and —O—C 1-6 alkyl; R 3 is selected from hydrogen, halo, and cyano; R 4 is selected from halo; —C 1-6 alkyl optionally substituted with 1 to 5 fluoro atoms; —O—C 1-6 alkyl optionally substituted with 1 to 5 fluoro atoms; —C 0-1 alkylene-phenyl; —O—C 0-3 alkylene-phenyl; —SO 2 —C 1-6 alkyl; —C(O)NH 2 ; and —NO 2 ; and n is 1 or 2; or a pharmaceutically acceptable salt thereof.