Patent ID: 8445207

Claim:
A method for screening of a drug inducing teratogenicity comprising the following steps: 1) preparing an experimental group comprising human placenta-originated cells treated with sample compounds containing said drug and preparing a control group comprising non-treated human placenta-originated cells; 2) separating RNA from the experimental group and the control group; and 3) confirming that the expression level of SEQ ID NO:57 of the experimental group is up-regulated compared with that of the control group, thereby indicating that said drug induces teratogenicity, wherein the confirming step of step 3) comprises the following: i) synthesizing cDNA from the RNA obtained from the experimental group and the control group, followed by labeling with different fluoresceins; ii) hybridizing the cDNA labeled with different fluoresceins of step i) with a DNA microarray chip for screening a drug inducing teratogenicity on which oligonucleotide of a sequence of the genes of step 3) or its complementary strand is integrated; and iii) confirming that the expression level of SEQ ID NO:57 of the experimental group is up-regulated compared with that of the control group, by analyzing the reacted DNA microarray chip of step ii).