Patent ID: 8324221

Claim:
A compound of Formula I: and tautomers, resolved enantiomers, resolved diastereomers, metabolites, salts and pharmaceutically acceptable prodrugs thereof, wherein: R 1 is H, CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , CH═CH 2 , CH 2 OH, CF 3 , CHF 2 , CH 2 F, or C 3 -C 6 cycloalkyl; R 2 is H, OH, OCH 3 or F; R 3 is H, F or CH 3 ; each R 4 is independently selected from H, F, Cl, Br, I, CN, (CH 2 ) t NR 10 R 10 , (CH 2 ) t OR 10 , (CH 2 ) t C(O)R 10 , (CH 2 ) t C(O)OR 10 , (CH 2 ) t C(O)NR 10 R 10 , (CH 2 ) t NR 10 C(O)R 10 , (CH 2 ) t NR 10 C(O)OR 10 , (CH 2 ) 1 NR 10 C(O)NR 10 R 10 , C 1 -C 6 alkyl, (CR 10 R 10 ) t C 3 -C 8 cycloalkyl, (CR 10 R 10 ) t C 3 -C 6 heterocyclyl, (CR 10 R 10 ) t C 6 -C 8 aryl, O(CR 10 R 10 ) t C 6 -C 8 aryl, (CR 10 R 10 ) t C 3 -C 6 heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one or more F, Cl, Br, I, CN, C 1 -C 3 alkyl, CF 3 , OH or O(C 1 -C 3 alkyl); R 5 is H, C 1 -C 6 alkyl, (CR 10 R 10 ) t OR 10 , (CR 10 R 10 ) t NR 10 R 10 , (CH 2 ) t C 3 -C 8 cycloalkyl, (CH 2 ) t C 6 -C 8 aryl, wherein said aryl is optionally substituted by F, Cl, Br or I; R 6 , R 7 , R 8 and R 9 are independently selected from H, C 1 -C 6 alkyl, (CR 10 R 10 ) t OR 10 , (CR 10 R 10 ) t C 6 -C 8 aryl; wherein said aryl is optionally substituted by F, Cl, Br or I; R 10 is independently selected from H, OH, O(C 1 -C 3 alkyl), (CH 2 ) t NR 11 R 11 , (CH 2 ) t C(O)NR 11 R 11 , (CH 2 ) t S(O)NR 11 R 11 , (CH 2 ) t S(O) 2 NR 11 R 11 , C 1 -C 6 alkyl, (CH 2 ) t C 3 -C 8 cycloalkyl, (CH 2 ) t C 3 -C 6 heterocyclyl, (CH 2 ) t C 6 -C 8 aryl and (CH 2 ) t C 3 -C 6 heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one or more F, Cl, Br, I, CN, C 1 -C 3 alkyl, CF 3 , OH, O(C 1 -C 3 alkyl); or two R 10 are taken together to form oxo or a C 3 -C 6 heterocyclyl; R 11 is independently selected from H, C 1 -C 3 alkyl, OH, OC 1 -C 3 alkyl, NH 2 , N(C 1 -C 3 alkyl) 2 ; or two R 11 are taken together to form a C 3 -C 6 heterocyclyl, optionally substituted by methyl or ethyl; m and n are independently 1, 2 or 3, provided that m and n taken together are 3, 4 or 5; p is 0,1,2 or 3; and each t is independently 0, 1, 2, 3 or 4.