Patent ID: 8252810

Claim:
A compound represented by the formula (D or pharmaceutically acceptable salt thereof: wherein Q represents ethylene or trimethylene, R 1 , R 2 and R 3 each independently represents hydrogen, halogen or hydroxy, or C 1-6 alkyl or C 1-6 ,alkoxy each optionally having one or more substituents selected from the group consisting of Group A, X 1 represents, cyclopropane-1,2-dimethylene, or C 1-6 alkylene or C 2-6 alkenylene each optionally having one or more substituents selected from the group consisting of Group B, X 2 represents C 1-6 alkylene, C 1-6 alkyleneoxy, oxyC 1-6 alkylene, C 1-6 alkylenethio, thio-C 1-6 alkylene, C 1-6 alkyleneoxy-C 1-6 alkylene, C 2-6 alkenylene, oxycarbonyl, carbonyloxy, C 1-6 alkyleneamnino, amino-C 1-6 alkylene, aminocarbonyl, carbonylamino, C 1-6 alkyleneaminocarbonyl, carbonylamino-C 1-6 alkylene, oxycarbonylamino, aminocarbonyloxy or ureylene each optionally having one or more substituents selected from the group consisting of Group C, A 1 is a group represented by the formula: wherein R 4 independently repesents hydrogen or C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkylmethyl, C 6-10 aryl, C 7-11 aralkyl or a 5- to 6-membered aromatic heterocyclic group each optionally having one or more substituents selected from the group consigtingof Group D1, and R 5 represents hydrogen, halogen, hydroxy, or amino optionally having one or two C 1-6 alkyl, or C 1-6 alkyl, C 2-6 alkenyl, C 3-8 cycloalkyl, C 3-8 cycloalkylmethyl, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 6-10 aryl, C 7-11 aralkyl or a 5- to 6-membered aromatic heterocyclic group each optionally having one or more-substituents selected from the group consisting of Group D1, A 2 represents C 3-8 cycloalkyl, C 6-14 aryl, a 5- to 6-membered aromatic heterocyclic group or a 9- to 11-membered benzo-fused heterocyclic group each optionally having one or more substituents selected from Group E, Group A: halogen, hydroxy and C 1-6 alkoxy, Group B: halogen, hydroxy, oxo, cyano, amino, C 1-6 alkyl, halo-C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, C 1-6 alkylsulfonylamino, hydroxyimino and C 1-6 alkoxyimino, Group C: halogen, hydroxy, C 1-6 alkoxy, oxo and C 1-6 alkyl, Group D1: halogen, hydroxy, C 1-6 alkyl and C 1-6 alkoxy, Group E: halogen, cyano, hydroxy, C 1-6 alkyl, halo-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkoxy and C 2-7 acyl, and C 6-10 aryl, a 5- to 6-membered heterocyclic group and a 5- to 6-membered aromatic heterocyclic group each optionally having one or more substituents selected from the group consisting of Group E1, and Group E1: halogen, C 1-6 alkyl, halo-C 1-6 alkyl, C 1-6 alkoxy and halo-C 1-6 alkoxy.