Patent ID: 7713999

Claim:
A compound represented by the structural formula or a pharmaceutically acceptable stereoisomer or salt thereof, wherein: represents an optional double bond; R 1 is methyl; R 2 is H; R 3 is H; Het is, pyridyl, wherein a ring nitrogen can form an N-oxide group, wherein Het is attached to B by a carbon atom ring member, and wherein the Het group is substituted by W; W is 1 to 4 moieties independently selected from the group consisting of phenyl or pyridyl, unsubstituted or substituted with R 21 ; R 10 is H, provided that when the optional double bond is present, R 10 is absent; B is CH═CH—; X is —O—; Y is ═O; R 21 is 1 to 3 substituents independently selected from the group consisting of H, CN, —CF 3 , —OCF 3 , and halogen; R 14 is independently selected from —(CH 2 ) n6 NHC(O)OR 16b , —(CH 2 ) n6 NHC(O)R 16b , —(CH 2 ) n6 NHC(O)NR 4 R 5 , —(CH 2 ) n6 NHSO 2 R 16 , —(CH 2 ) n6 NHSO 2 NR 4 R 5 , and —(CH 2 ) n6 C(O)NR 28 R 29 where n 6 is 0-4; R 16b is alkoxy, C 1 -C 6 alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl-, R 22 —O—C(O)—(C 1 -C 6 )alkyl-, C 3 -C 6 -cycloalkyl, R 28 R 29 N—(CO)—(C 1 -C 6 )alkyl-, R 28 R 29 N—(CO)O—(C 1 -C 6 )alkyl-, -hydroxy(C 1 -C 6 )alkyl); R 22 is H or (C 1 -C 6 )alkyl; and, R 28 and R 29 are independently selected from the group consisting of H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, R 27 -aryl(C 1 -C 6 )alkyl, heteroaryl, heteroarylalkyl, hydroxy(C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, heterocyclyl, heterocyclylalky, halogen and haloalkyl; or R 28 and R 29 taken together form a spirocyclic or a heterospirocyclic ring of 3-6 atoms.