Patent ID: 7557222

Claim:
Compounds of the formula I in which R is H, X, A, X—CO— or A-CO—, R 1 is H, ═O, Hal, X, A, OH, OA, A-COO—, A-CONH—, A-CONA-, N 3 , NH 2 , NO 2 , CN, COOH, COOA, CONH 2 , CON(A) 2 , O-allyl, O-propargyl, O-benzyl, ═N—OH, ═N—OA, OCH 2 CH(OH)CH 2 OH, A-O—CO—(CH 2 ) m —O—, —O(CH 2 ) m COOH or —O(CH 2 ) m OA, R 2 is H, Hal or A, R 3 is 2-oxopiperidin-1-yl, 2-oxopyrrolidin-1-yl, 2-oxo-1H-pyridin-1-yl, 3-oxomorpholin-4-yl, 4-oxo-1H-pyridin-1-yl, 2-oxo-1H-pyrazin-1-yl, 2-oxoimidazolidin-1-yl, 2-iminopiperidin-1-yl, 2-iminopyrrolidin-1-yl, 3-iminomorpholin-4-yl, 2-iminoimidazolidin-1-yl, 2-imino-1H-pyrazin-1-yl, 2,6-dioxopiperidin-1-yl, 2-oxopiperazin-1-yl, 2,6-dioxopiperazin-1-yl, 2,5-dioxopyrrolidin-1-yl, 2-oxo-1,3-oxazolidin-3-yl, 3-oxo-2H-pyridazin-2-yl, 2-caprolactam-1-yl (=2-oxoazepan-1-yl), 2-azabicyclo[2.2.2]octan-3-on-2-yl, 5,6-dihydro-1H-pyrimidin-2-oxo-l-yl, 2-oxo-1,3-oxazinan-3-yl, 4H-1,4-oxazin-4-yl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl or pyrazinyl, optionally mono- or disubstituted by Hal, OA, OH, COOA and/or A, or CONR 4 R 5 , R 2 and R 3 together are alternatively —CH═CH—NH— or —CH 2 —CH 2 —NH, where one H atom may be replaced by A-CO— or A-O—CO—, R 4 and R 5 , independently of one another, are H or A, or R 4 and R 5 together are alternatively an alkylene chain having 3, 4 or 5 carbon atoms, which may also be substituted by A, Hal, OA and/or carbonyl oxygen (═CO), X is aryl, arylalkyl, Het or Het-alkyl, aryl is phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OH, NH 2 , NO 2 , CN, COOH, COOA, CONH 2 , NHCOA, NHCONH 2 , NHSO 2 A, CHO, COA, SO 2 NH 2 , SO 2 A, —CH 2 —COOH or —OCH 2 —COOH, Het is a mono- or bicyclic saturated, unsaturated or aromatic heterocyclic radical having from 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by Hal, A, benzyl, cycloalkyl, OH, NH 2 , NHCONH 2 , NO 2 , CN, —CH 2 —COOH, —CH 2 —CONH 2 , NHCOA, NR 3 SO 2 A, CHO, SO 2 NH 2 , SO 2 A and/or carbonyl oxygen, A is unbranched, branched or cyclic alkyl having 1-10 carbon atoms, in which, in addition, 1-7 H atoms may be replaced by F and/or chlorine, Hal is F, Cl, Br or I, m is 1, 2, 3, 4, 5 or 6, n is 0, 1, 2, 3, 4, 5 or 6, or pharmaceutically acceptable salts, stereoisomers or mixtures thereof in all ratios.