Patent ID: 7939539

Claim:
A compound having the formula: or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein X is O or S; R 1 is substituted alkyl; R 2 is selected from the group consisting of (1) hydrogen, (2) substituted or unsubstituted alkyl, (3) substituted or unsubstituted alkenyl, and (4) substituted or unsubstituted alkynyl; R 3 is selected from the group consisting of: (1) CO 2 R 10 , and (2) CONR 11 R 12 ; R 4 is selected from the group consisting of: (1) hydrogen, (2) substituted or unsubstituted alkyl, (3) substituted or unsubstituted alkenyl, (4) substituted or unsubstituted alkynyl, (5) substituted or unsubstituted aryl, (6) substituted or unsubstituted heteroaryl, and (7) substituted or unsubstituted heterocyclyl; R 5 is selected from the group consisting of: (1) hydrogen, (2) substituted or unsubstituted alkyl, (3) substituted or unsubstituted alkoxy, (4) substituted or unsubstituted aryl, (5) substituted or unsubstituted heteroaryl, (6) substituted or unsubstituted heterocyclyl, (7) COR 17 , (8) CO 2 R 18 , (9) CONR 19 R 20 , and (10) SO 2 R 21 ; R 6 , R 7 , R 8 , and R 9 are independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxy, (4) nitro, (5) amino, (6) cyano, (7) alkoxy, (8) alkylthio, (9) methylenedioxy, (10) haloalkoxy, (11) CO 2 R 10 , (12) COR 10 , (13) OR 10 , (14) CONR 11 R 12 , (15) substituted or unsubstituted alkyl, (16) substituted or unsubstituted aryl, (17) substituted or unsubstituted heteroaryl, (18) substituted or unsubstituted alkylamino, (19) substituted or unsubstituted dialkylamino, (20) substituted or unsubstituted alkylsulfonyl, (21) substituted or unsubstituted arylsulfonyl, (22) substituted or unsubstituted alkylcarboxy, (23) substituted or unsubstituted carboxamido, (24) substituted or unsubstituted carboxyamino, (25) substituted or unsubstituted aminocarboxy, (26) substituted or unsubstituted aminocarbonyl, and (27) substituted or unsubstituted alkylsulfonamido; R 10 , R 11 , R 12 , R 17 , R 18 , R 19 , R 20 , and R 21 are independently selected from the group consisting of: (1) hydrogen, (2) substituted or unsubstituted alkyl, (3) substituted or unsubstituted alkenyl, (4) substituted or unsubstituted alkynyl, (5) substituted or unsubstituted aryl, (6) substituted or unsubstituted heteroaryl, and (7) substituted or unsubstituted heterocyclyl; or R 11 and R 12 , or R 19 and R 20 taken together form a 3- to 7-membered carbocyclic or heterocyclic ring; and m=0, 1, or 2.