Patent ID: 7943618

Claim:
A compound of formula I wherein: X 1 is N; R I is C(═O)NHR 6 , phenyl or heteroaryl wherein said heteroaryl is selected from the group consisting of pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl; pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 2-C 1-6 alkyl-pyridazin-3-on-6-yl, 2-benzyl-pyridazin-3-on-6-yl, 1,4,5,6-tetrahydro-pyrimidin-2-yl and 4,5-dihydro-1H-imidazol-2-yl; R 6 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, pyridinyl -C 1-3 alkyl, phenyl or phenyl-C 1-3 alkyl said phenyl optionally substituted with C 1-6 alkyl, C 1-6 alkoxy, C 1-6 heteroalkoxy, halogen, CONR a R b , CO 2 R g . R a and R b (i) selected independently are hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 1-3 alkoxy-C 1-3 alkyl, carboxy-C 1-3 alkyl, C 3-6 cycloalkyl or heterocyclyl; (ii) together are (CH 2 ) m X 2 (CH 2 ) 2 wherein m is 2 or 3 and X 2 is O, S(O) n or NR 8 and n is zero to two, and R 8 is hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl or C 1-3 acyl; or (iii) together with the nitrogen to which they are attached are piperidinyl or pyrrolidinyl said piperidinyl or said pyrrolidinyl optionally substituted with hydroxy, C 1-3 alkoxy, C 1-3 hydroxyalkyl; R g is hydrogen or C 1-6 alkyl; R 2 is hydrogen or C 1-6 alkyl; R 3 and R 4 are independently hydrogen, halogen, amino, C 1-6 hydroxyalkyl, C 1-6 alkyl or cyclopropyl; R 5 is (i) phenyl, (ii) heteroaryl selected from the group consisting of pyridinyl, benzo[b]thiophen-2-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, thiophenyl, 1′,2′,3′,4′,5′,6′-hexahydro-[2,4′]bipyridin-5-yl and C 1-3 alkyl-indolyl optionally substituted with one or two C 1-6 alkyl or halogen; (iii) azetidin-1-yl, pyrrolidin-2-yl, piperidin-1-yl, azepan-1-yl or 2,3-dihydro-1H-isoindolin-2-yl, or 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine; (iv) NR c R d wherein R c and R d together are (CH 2 ) o X 2 (CH 2 ) p , wherein o and p are independently 1 or 2, and X 2 is as defined above, or R c and R d independently are hydrogen C 1-10 alkyl or C 1-10 hydroxyalkyl; wherein R 9 is hydrogen, halogen or C 1-6 alkyl; wherein said phenyl, heteroaryl, azetidin-1-yl, pyrrolidin-2-yl, piperidin-1-yl, azepan-1-yl or 2,3-dihydro-1H-isoindolin-2-yl ring is optionally substituted with one to three groups independently selected from the group consisting of (a) halogen, (b) C 1-6 alkyl, (b) C 2-6 alkenyl, (c) C 2-6 alkynyl, (d) C 1-6 haloalkyl, (e) C 1-6 heteroalkyl, (f) C 3-7 cycloalkyl optionally substituted with one to three groups selected from C 1-6 alkyl, C 1-6 haloalkyl or halogen, (g) C 1-6 alkoxyalkyl, (h) hydroxy, (i) NR e R f , wherein R e and R f are (i) independently hydrogen, C 1-6 alkyl or (ii) together are (CH 2 ) m X 3 (CH 2 ) 2 wherein m is 2 or 3 and X 3 is CH 2 , O, S(O) n or NR 8 and n is zero to two and R 8 is as defined above; (j) C 1-6 alkoxy, (k) trialkylsilyl, (l) C 1-6 cyanoalkyl and (m) SF 5 A is —NHC(═O)—, C(═O)NH—, NHC(═O)NH, CH 2 C(═O), CH 2 SO 2 or R 5 is (v) or (vi) A is absent; or a pharmaceutically acceptable salt thereof.