Patent ID: 7608618

Claim:
A compound having a formula wherein: Y′ is O or S; W′ is optionally substituted with from one to four substituents selected from the group consisting of C 1-6 alkyl, aryl, N(R 7 ) 2 , OR 7 , N 3 , CN, C(O)R 7 , C 1-3 alkylenearyl, C 1-3 alkyleneN(R 2 ) 2 , halo, and Z′ is selected from the group consisting of: wherein: Q′ is OR 7 ; J′ is selected from the group consisting of CR 8 , NR 8 , O, and S; K′ is selected from the group consisting of CR 9 , NR 9 , O, and S; L′ is selected from the group consisting of CR 10 , NR 10 , O, and S; M′ is selected from the group consisting of CR 11 , NR 11 , O, and S; and provided when Z′ is a six-membered ring J′, K′, L′ and M′ cannot be O or S; wherein: R 7 is C 1-3 alkyleneC 3-8 heterocycloalkyl; R 8 , R 9 , and R 10 are each independently selected from the group consisting of hydrogen, halo, optionally substituted C 1-6 alkyl, C 2-6 alkenyl, OCF 3 , NO 2 , CN, NC, N(R 7 ) 2 , OR 7 , CO 2 R 7 , C(O)N(R 7 ) 2 , C(O)R 7 , N(R 13 )C(O)R 7 , N(R 13 )C(O)OR 7 , N(R 7 )C(O)OR 7 , N(R 7 )C(O)C 1-3 alkyleneC(O)R 7 , N(R 7 )C(O)C 1-3 alkyleneC(O)OR 7 , N(R 7 )C(O)C 1-3 alkyleneOR 7 , N(R 7 )C(O)C 1-3 alkyleneNHC(O)OR 7 , N(R 7 )C(O)C 1-3 alkyleneSO 2 NR 7 , CF 3 , C 1-3 alkyleneN(R 12 )SO 2 aryl, C 1-3 alkyleneN(R 12 )SO 2 heteroaryl, C 1-3 alkyleneOC 1-3 alkylenearyl, C 1-3 alkyleneN(R 12 )C 1-3 alkylenearyl, C 1-3 alkyleneN(R 12 )C 1-3 alkyleneheteroaryl, C 1-3 alkyleneN(R 12 )C(O)R 7 , C 1-3 alkyleneN(R 12 )C(O)C 1-3 alkyleneOR 2 , C 1-3 alkyleneN(R 12 )C(O)aryl, C 1-3 alkyleneN(R 12 )C(O)C 1-3 alkyleneN(R 12 ) 2 , C 1-3 alkyleneN(R 12 )C(O)heteroaryl, C 1-3 alkyleneOR 7 , and SR 7 , wherein R 7 is as defined above; R 11 is selected from the group consisting of hydrogen, optionally substituted C 1-6 alkyl, and halo; R 12 is selected from the group consisting of hydrogen, C 1-6 alkyl, cycloalkyl, aryl, heteroaryl, C 1-3 alkylenearyl, and SO 2 C 1-6 alkyl, or two R 12 groups are taken together to form an optionally substituted 3- to 6-membered ring; and R 13 is hydrogen; or a pharmaceutically acceptable salt thereof.