Patent ID: 8242303

Claim:
A method for producing an optically active N-(halopropyl)amino acid derivative, comprising: obtaining a compound represented by formula (III): by reacting an optically active alanine ester represented by formula (I): or a salt thereof with a halogenated propane represented by formula (II): and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV): by introducing R 2 C(O) onto the nitrogen atom of the compound represented by formula (III), wherein X 1 and X 2 are different from each other and are atoms selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom, X 2 is an atom that has an atomic number larger than the atomic number of X 1 , R 1 is a linear or branched alkyl group having 1 to 4 carbon atoms that is optionally substituted with a phenyl group or is a p-nitrophenyl group, R 2 is a phenyl group, a methyl group, a tert-butyl group, a tert-butoxy group, a benzyloxy group, a methoxy group, or a 9-fluorenylmethoxy group, and the asterisk (*) indicates an asymmetric carbon atom.