Patent ID: 7105665

Claim:
A process for the preparation of a compound of Formula I or Formula II: wherein: R 1 and R 2 are independently chosen from hydrogen, optionally substituted alkyl, or a group -D-E, in which D is a covalent bond or alkylene, and E is optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, opltonally substituted alkenyl, or optionally substituted alkynyl, with the proviso that when D is a covalent bond E cannot be alkoxy; R 3 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; X is optionally substituted arylene or heteroarylene; Y is a covalent bond or alkylene in which one carbon atom can be optionally replaced by —O—, —S—, or —NH—, and is optionally substituted by hydroxy, alkoxy, optionally substituted amino, or —COR, in which R is hydroxy, alkoxy or amino; with the proviso that when the optional substitution is hydroxy or amino it cannot be adjacent to a heteroatom; and Z is optionally substituted monocyclic aryl or optionally substituted monocyclic heteroaryl; or Z is hydrogen when X is optionally substituted heteroarylene and Y is a covalent bond; with the proviso that Z is hydrogen only when Y is a covalent bond and X is optionally substituted 1,4-pyrazolene; and, with the proviso that when X is optionally substituted arylene, Z is optionally substituted monocyclic heteroaryl comprising: contacting a compound of the formula: in which R 1 , R 2 and R 3 are as defined above; with a compound of the formula Z—Y—X—CO 2 H, in which X, Y, and Z are as defined above in the presence of a carbodiimide.