Patent ID: 6872833

Claim:
A compound of formula I wherein R 1 is selected from (RS)-[1,4]dioxan-2-yl-, (R)-[1,4]dioxan-2-yl-, and (S)-[1,4]dioxan-2-yl-; R 2 is a) —(CH 2 ) n -pyridin-2,3 or 4-yl, or —(CH 2 ) n -pyridin-2,3 or 4-yl substituted by -lower alkyl, —(CH 2 ) m —O-lower alkyl, —(CH 2 ) m NR′R″, —(CH 2 ) m morpholinyl, —(CH 2 ) m -pyrrolidin-1-yl, —(CH 2 ) m -piperidine-1-yl, —(CH 2 ) m -piperidine-1-yl substituted by hydroxy, —(CH 2 ) m —O—(CH 2 ) o —CF 3 , —(CH 2 ) n —O—(CH 2 ) m -cycloalkyl, —(CH 2 ) m —O—(CH 2 ) o —O-lower alkyl, —(CH 2 ) m —O—(CH 2 ) o -2-oxo-pyrrolidin-1-yl, —(CH 2 ) m —O-tetrahydropyran-4-yl —(CH 2 ) m —O—(CH 2 ) o -morpholinyl, -di-hydropyran-4-yl, -tetra-hydropyran-4-yl -azetidin-1-yl, or -azetidin-1-yl substituted by halogen, lower alkoxy or hydroxy; or b) —(CH 2 ) n -piperidine-1-yl, or —(CH 2 ) n -piperidine-1-yl substituted by one or two substituents selected from -hydroxy, -hydroxy-lower alkyl, -lower alkyl and —(CH 2 ) m —O-lower alkyl; or c) —(CH 2 ) n -phenyl, or —(CH 2 ) n -phenyl substituted by one or two substituents selected from -halogen, -lower alkyl, -lower alkoxy and —(CH 2 ) n —NR′R″; or d) -benzo[1.3]dioxol-5-yl; —(CH 2 ) n -morpholinyl; —(CH 2 ) n -tetrahydropyran-4-yl; —(CH 2 ) n —O-lower alkyl; —(CH 2 ) n -cycloalkyl; —(CH 2 ) n —C(O)—NR′R″; —(CH 2 ) n -2-oxo-pyrrolidin-1-yl; —(CH 2 ) n NR′R″; -2-oxa-5-aza-bicyclo[2.2.1]heptane-5-yl; or -1-oxa-8-aza-spiro[4.5]decane-8-yl; R′ and R″ are each independently selected from lower alkyl; —(CH 2 ) o —O-lower alkyl; cycloalkyl; lower alkyl substituted by one or more substituents selected from hydroxy and lower alkyl; —(CH 2 ) o —O-lower alkyl substituted by one or more substituents selected from hydroxy and lower alkyl; and cycloalkyl substituted by one or more substituents selected from hydroxy and lower alkyl; n is 0, 1, 2 or 3; m is 0 or 1; and o is 1 or 2; or a pharmaceutically acceptable salt thereof.