Patent ID: 7226991

Claim:
A compound of the formula: W—Y—(AA) n -Z wherein n is 1 to 15; Y is a phenylalanyl radical having a phenyl ring, an amine end, a carboxyl end, and a —CH 2 CH< group attached to the phenyl ring at the —CH 2 and the amine end and the carboxyl end attached to the CH<, the phenyl ring having one or more substituents selected from the group consisting of hydroxyl, carboxyl, formyl, carboxylalkyl, carboxyalkyloxy, dicarboxylalkyl, dicarboxyalkyloxy, dicarboxyhaloalkyl, dicarboxyhaloalkyloxy, and phosphonoalkyl, phosphonohaloalkyl, wherein the alkyl portion of the substituents of the phenyl ring may be unsubstituted or substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, and alkoxy; W is a moiety attached to the nitrogen of Y and is selected from the group consisting of alkylcarbonyl, oxalyl, alkylaminooxalyl, arylaminooxalyl, arylalkylaminooxalyl, alkoxyoxalyl, carboxyalkyl carbonyl, heterocyclyl carbonyl, heterocyclylalkyl carbonyl, arylalkyl heterocyclylalkyl carbonyl, aryloxycarbonyl, and arylalkoxycarbonyl, wherein the aryl and alkyl portions of W may be unsubstituted or substituted with a substituent selected from the group consisting of halo, hydroxy, aminoalkyl, alkyl, and alkoxy; and the heterocyclyl portion of W contains at least 4 hereto atoms selected from the group consisting of O, N, and S; AA is an amino acid, the amine end of which is attached to the carboxyl end of Y; and Z is arylalkylamino or aryl heterocyclyl C 1 –C 6 alkylamino wherein an aryl group, which may be substituted or unsubstituted, is linked to a heterocyclyl group; wherein aryl is a carbocyclic aryl; or a salt thereof; with the proviso that Z is not arylalkylamino when W is oxalyl or acetyl and the phenyl ring of phenylalanyl contains a hydroxyl, malonyl difluoromethyl, malonyloxy, carboxyalkyloxy, phosphonodifluoromethyl, or phosphonomethyl substituted on the phenyl, ring at a position para to the —CH 2 CH< group and the ortho and meta positions are unsubstituted and the proviso that Z is not arylalkylamino when W is arylalkoxycarbonyl and the substituent on the phenyl ring of Y is phosphonomethyl.