Patent ID: 7973173

Claim:
A process for the synthesis of trandolapril of Formula (I) which comprises condensing N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine carboxyanhydride compound of formula (II) with trans octahydro-1H-indole-2-carboxylic acid of formula (III); in a first organic solvent comprising a water immiscible inert organic solvent and in the presence of a base, and isolating trandolapril of formula (I) from a second organic solvent, wherein the N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride compound of formula (II) is reacted in a sub-molar proportion relative to the trans octahydro-1H-indole-2-carboxylic acid of formula (III).