Patent ID: 8551445

Claim:
A method of alkylating a target compound comprising synthesizing an alkylating agent having the formula: X—(CR 1 R 2 ) a CR 3 R 4 -LG wherein, a is 1 or 2, R 1 , R 2 , R 3 and R 4 are independently H, X or alkyl, X is a halogen or a label, with the proviso that at least one X is 18 F, LG is a leaving group, and wherein said synthesizing occurs at a temperature from about 40° C. to about 50° C.; and reacting said alkylating agent with a target compound comprising an alkylation reactive group under conditions suitable for the alkylation of said target compound and thereby forming an alkylated target compound, wherein said reacting is accomplished without purifying said alkylating agent after said synthesizing.