Patent ID: 8148342

Claim:
A method of treating a patient at risk for the development of, or suffering from, acute renal failure comprising administering to the patient a double-stranded compound having the structure: 5′ ugaagggugaaauauucuc 3′ (antisense strand) (SEQ ID NO: 48) 3′ acuucccacuuuauaagag 5′ (sense strand) (SEQ ID NO: 25) wherein each of a, c, u and g is an unmodified or 2′O-Methyl sugar modified ribonucleotide and each consecutive ribonucleotide is joined to the next ribonucleotide by a covalent bond; wherein alternating ribonucleotides in both the antisense strand and the sense strand are 2′O-Methyl sugar modified; wherein a 2′O-Methyl sugar modified ribonucleotide is present at both the 5′ terminus and the 3′ terminus of the antisense strand and an unmodified ribonucleotide is present at both the 5′ terminus and the 3′ terminus of the sense strand; and wherein the compound is administered in an amount effective to treat the patient.