Patent ID: 7498345

Claim:
A process for preparing a piperidine derivative compound of formula I: wherein R 4 is selected from the group comprising H, alkyl, and aryl; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, fluorine, chlorine, alkyl, aryl, hydroxyl, alkoxy, and aryloxy; said process comprising: (a) reacting a compound of formula VIa wherein X is a group chosen from chlorine, bromine, iodine, —OSO 2 R 5 , and diazonium salt displaceable via oxidative metallic addition; and LG is a leaving group displaceable by a secondary amine, said leaving group chosen from chlorine, bromine, iodine, and —OSO 2 R 5 , wherein R 5 is chosen from alkyl, fluoroalkyl, aryl, and substituted aryl; with a piperidine compound of formula IX in the presence of a base to provide a compound of formula Ia (b) reacting the compound of Ia with an isobutyrate equivalent of formula IV wherein R 8 is a trialkylsilyl, in the presence of a transition metal catalyst having a metal selected from the group comprising of Ni and Pd, and ZnF 2 to provide the compound of formula I.