Patent ID: 7910378

Claim:
A method for selectively enhancing the bioavailability of a hydrophobic drug over that of metabolites of the hydrophobic drug, the method comprising: (a) providing in combination in a medium: (i) a sample suspected of containing a hydrophobic drug, (ii) a releasing agent for releasing the hydrophobic drug and the metabolites from endogenous binding moieties, and (iii) a selective solubility agent for the hydrophobic drug wherein the selective solubility agent comprises a water miscible, non-volatile organic solvent and wherein the concentration of the selective solubility agent in the medium is sufficient to enhance the bioavailability of the hydrophobic drug over that of the metabolites in the medium, and (b) incubating the medium under conditions for enhancing the bioavailability of the hydrophobic drug over that of the metabolites in the medium.