Patent ID: 8445023

Claim:
A method of preparing a pharmaceutical formulation for combating the misuse of active principle (AP), the method comprising: providing inert cores; coating the inert cores with at least one layer comprising the active principle; coating the at least one layer comprising the active principle with at least one coating layer (Ra) to create modified release coated microparticles resistant to crushing; wherein said at least one coating layer (Ra) represents a fraction by weight (Tp) greater than 30%, expressed in % by dry weight, based on the total weight of the coated microparticles, whereby said at least one coating layer (Ra) comprises: at least one film-forming (co)polymer (A1) insoluble in the gastrointestinal juices present in a proportion of 60% to 90% by weight on a dry basis, relative to the total mass of the coating composition; at least one (co)polymer soluble in the gastrointestinal juices (A2) present in a proportion of 5% to 40% by weight on a dry basis, relative to the total mass of the coating composition; and at least one plasticizer (A3) present in a proportion of 1% to 30% by weight on a dry basis, relative to the total mass of the coating composition; and wherein said formulation further comprises at least one viscosifier (Vb) whereby said formulation further comprises at least one AP sequestering agent Q, whereby a complex with the AP is formed in solution.