Patent ID: 8642035

Claim:
A purified antibody that specifically binds TrkB, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region and the light chain variable region each comprise the following three complementary determining regions (CDRs): CDR1, CDR2 and CDR3; wherein: i) the CDR1 of the heavy chain variable region comprises an amino acid sequence of SEQ ID NO:25; ii) the CDR2 of the heavy chain variable region comprises an amino acid sequence selected from the group consisting of SEQ ID NO:28, SEQ ID NO:29 and SEQ ID NO:30; iii) the CDR3 of the heavy chain variable region comprises an amino acid sequence selected from the group consisting of SEQ ID NO:32 and SEQ ID NO:33; iv) the CDR1 of the light chain variable region comprises an amino acid sequence selected from the group consisting of SEQ ID NO:35, SEQ ID NO:36 and SEQ ID NO:37; v) the CDR2 of the light chain variable region comprises an amino acid sequence of SEQ ID NO:39; vi) the CDR3 of the light chain variable region comprises an amino acid sequence selected from the group consisting of SEQ ID NO:40 and SEQ ID NO:41.