Patent ID: 6914138

Claim:
A compound of the formula: wherein: X is independently selected from the group consisting of H, aryl, aralkyl, alkyl, alkaryl, alkenyl, alkynyl, alkoxy, —NR 10 2 , and —C(O)C(R 8 ) 2 CH(R 8 )NR 1 R 2 , and wherein at least one of X is —C(O)C(R 8 ) 2 CH(R 8 )NR 1 R 2 ; R 1 and R 2 are independently selected from the group consisting of H, C 1 -C 18 alkyl, alkenyl or alkynyl, phenyl, aralkyl, alkaryl, an alkanoic acid, an ester or amide derivative of an alkanoic acid, a peptide fragment, an HIV aspartyl protease inhibitor, a group that is cleaved intracellularly, and a group that increases the hydrophilicity, hydrophobicity, or hydrogen bonding capacity of the compound; R 3 , R 4 and R 5 are independently selected from the group consisting of H, —OH, protected oxy-, —NH 2 , F, —N 3 , —CN, —NC, —OAc, —SAc, —OBz, and —OSiR 7 3 , wherein R 7 is C 1 -C 4 alkyl or phenyl; R 6 is selected from the group consisting of —OH, protected oxy-, phosphate, diphosphate, triphosphate, phosphate esters, phosphoramidites, phosphorothionates, and phosphorodithionates; R 8 is independently selected from the group consisting of H, aryl, aralkyl, alkyl, alkaryl, alkenyl, alkynyl, alkoxy, and —C(O)—R 9 , where R 9 selected from the group consisting of H, alkyl, aryl, aralkyl, alkaryl and alkoxy; R 10 is independently selected from the group consisting of H, alkyl, aryl, aralkyl, alkaryl and R 9 C(O); the protected oxy-groups of R 4 and R 5 taken together can represent an isopropylidene group of the formula (—OC(CH 3 ) 2 O—) or an orthoformate group of the formula (—OCH(OR 7 )O—); and the protected oxy-groups of R 5 and R 6 taken together can represent a 3′,-5′-tetraalkyldisiloxane group (—OSi(alkyl) 2 OSi(alkyl) 2 O—).