Patent ID: 8318667

Claim:
A compound represented by formula I: or a pharmaceutically acceptable salt thereof wherein: each R 1 represents H or is selected from: halo, CN, OH, NO 2 , CO 2 R a , NR a R b , S(O) p R a , C 1-10 alkyl, C 2-10 alkenyl or C 1-10 alkoxy, the alkyl and alkenyl portions of C 1-10 alkyl, C 2-10 alkenyl and C 1-10 alkoxy being optionally substituted with 1-5 halo atoms up perhalo; and further optionally substituted with 1 group selected from: OH, oxo or C 1-6 alkoxy; p represents 0, 1 or 2; each R a and R b independently represents H or C 1-4 alkyl optionally substituted with 1-5 halo atoms up to perhalo; and further optionally substituted with 1 group selected from: OH, oxo or C 1-6 alkoxy; R 2 represents C 1-6 alkyl or C 2-6 alkenyl, each optionally substituted with 1-5 halo atoms up to perhalo, and further optionally substituted with 1 group selected from: OH, oxo or C 1-6 alkoxy: each R 3 represents H or halo, or 1-2 R 3 groups represent H or halo and the remainder represent a member selected from: CN, OH, NO 2 , CO 2 R a , NR a R b , S(O) p R a , phenyl or 5-6 membered heteroaryl containing 1-3 nitrogen atoms and 0-1 oxygen or sulfur atoms, said phenyl and heteroaryl being optionally substituted with 1-3 halo atoms and 1-2 members selected from: S(O) p R a , C 1-3 alkyl, C 1-3 alkoxy, haloC 1-3 alkyl, haloC 1-3 alkoxy, C 1-10 alkyl, C 2-10 alkenyl or C 1-10 alkoxy, the alkyl and alkenyl portions of C 1-10 alkyl, C 2-10 alkenyl and C 1-10 alkoxy being optionally substituted with 1-5 halo atoms up to perhalo; and further optionally substituted with 1 group selected from: OH, oxo, NR a R b , or C 1-6 alkoxy; and R 4 represents H or is selected from: C 1-4 alkyl, haloC 1-4 alkyl, phenyl optionally substituted with 1-3 halo groups and 1-2 C 1-3 alkyl; haloC 1-3 alkyl, OC 1-3 alkyl or haloC 1-3 alkyl groups.