Patent ID: 7901671

Claim:
A self-inactivating (SIN) Human Immunodeficiency Virus (HIV) vector comprising: a) a 5′ HIV LTR; b) a hepatitis B virus post-transcriptional regulatory element (PRE) or an HIV reverse response element (RRE); c) a lentiviral central polypurine tract/DNA flap (cPPT/FLAP); c) a β-globin promoter; d) a β-globin locus control region (LCR); and e) a 3′ HIV LTR comprising: i) at least one deletion compared to the wild type 3′ HIV LTR; and ii) an insulator element comprising the nucleotide sequence set forth in SEQ. ID No.: 2 wherein the β-globin promoter and β-globin LCR within the SIN vector are operatively linked to a gene of interest.