Patent ID: 7271169

Claim:
A compound of Formula I: wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are hydrogen, or lower alkyl; or R 1 and R 2 , R 3 and R 4 , R 5 and R 6 , R 7 and R 8 , when taken together with the carbon to which they are attached, represent carbonyl with the proviso that the maximum number of carbonyl groups is 2; R 9 is —NHSO 2 R 12 , —NHC(O)R 12 , or —OR 12 ; in which R 12 is lower alkyl optionally substituted with halo, hydroxy, or CF 3 ; and R 10 is 2-methylbenzo-1,3-thiazol-5-yl, 2-cyclohexylbenzo-1,3-thiazol-5-yl, 2-phenylbenzo-1,3-thiazol-5-yl, or 2-phenylbenz-1,3-oxazol-5-yl; X is phenyl, naphthyl, or fluorenyl optionally substituted with halo, hydroxy, CF 3 , phenyl, or alkyl wherein the phenyl or alkyl substituent may be further substituted with halo or CF 3 ; Y is (CH 2 ) n , in which n is 0, 1, or 2; Z is —N<, —NH—C(O)—N<, or —NH—C(O)—CH 2 —N< and pharmaceutically acceptable salts and polymorphs thereof.