Patent ID: 7109225

Claim:
A compound of formula (I) wherein R 1 is alkyl, fluoro-lower-alkyl, cycloalkyl, bicyclic cycloalkyl, or tricyclic cycloalkyl; R 2 is hydrogen, lower-alkyl, or fluoro-lower-alkyl; R 3 , R 4 , R 5 , and R 6 are independently selected from the group consisting of hydrogen, hydroxy, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, hydroxy-lower-alkoxy, lower-alkoxy-lower-alkoxy, and lower-alkenyl, wherein at least one of R 3 , R 4 , R 5 , or R 6 is not hydrogen, or R 3 and R 4 are bonded to each other to form a ring together with the carbon atoms to which they are attached, and R 3 and R 4 together are —CH═CH—S—, —S—CH═CH—, —CH═CH—O—, —O—CH═CH—, —CH═CH—CH═CH—, —O—(CH 2 ) 2-3 —, —(CH 2 ) 2-3 —O—, or —(CH 2 ) 3-5 —, and R 5 and R 6 are as defined above, R 7 is lower-alkyl, fluoro-lower-alkyl, lower-alkenyl, aryl, or aryl-lower-alkyl; R 8 is hydrogen or lower-alkyl; n is 1, 2 or 3; or pharmaceutically acceptable salts or pharmaceutically acceptable esters thereof.