Patent ID: 8703736

Claim:
A method for identifying a pancreatic cancer responding to inhibition of pancreatic tumor cell proliferation by a ROCK1 inhibitor treatment in a subject in need thereof, comprising the steps of: a) receiving a pancreatic cancer sample from the subject; b) detecting an abnormality of a ROCK1 gene comprising SEQ ID NO: 1 in the sample from the subject; and c) identifying in the subject who is sensitive to the ROCK1 inhibitor treatment according to the detection of the ROCK1 abnormality in the sample provided by the subject, wherein the abnormality of the ROCK1 gene comprises (i) gene overexpression, detected by comparing the level of ROCK1 gene expression in the sample from the subject to a control sample free of pancreatic cancer cell or a control sample having pancreatic cancer non-responding to the ROCK1 inhibitor treatment, and/or; (ii) gene amplification, detected by comparing ROCK1 gene copy number in the sample from the subject to a control sample free of pancreatic cancer cell or a control sample having pancreatic cancer non-responding to the ROCK1 inhibitor treatment.