Patent ID: 7014869

Claim:
A method of preparing water soluble particles comprising a coprecipitant core with a dehydrated biological macromolecule coated thereon comprising the steps of: a) preparing an aqueous solution comprising a coprecipitant and a biological macromolecule wherein the coprecipitant core consists of one of the following of inorganic salts; sugars, polyols, and derivatives thereof with a molecular weight less than 10,000 Da; amino-acids; acid-base buffers; zwitterionic compounds; organic salts; compounds containing multiple basic groups; compounds containing multiple acidic groups; bile salts; and, water soluble dyes; b) rapidly admixing the biological macromolecule/coprecipitant solution with an excess of a water miscible organic solvent such that the coprecipitant and bioactive molecule immediately coprecipitate from solution forming said particles; and c) isolating said particles from the organic solvent.