Patent ID: 8383879

Claim:
A non-human animal disease model for hepatitis B virus-associated liver disease, comprising a hepatitis B virus genome in the liver cells thereof and exhibiting at least one or more of the following symptoms: (a) expression of hepatitis B viral particles in the serum for more than 2 weeks; (b) hepatitis B viral DNA in the serum; (c) hepatitis B virus (HBV) envelope and HBV e proteins in the serum; and (d) expression of hepatitis B virus (HBV) core and HBV envelope proteins in the liver but not in the kidney, heart, lung, brain, pancreas, spleen, stomach or intestine tissues thereof, wherein the hepatitis B virus genome is transduced into the liver cells with an adenovirus-associated vector (AAV) comprising a hepatitis B virus genomic DNA insert.