Patent ID: 8071612

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable salts and the stereo-chemically isomeric forms thereof, wherein n is 0, 1 or 2; X is CR 7 , wherein R 7 is taken together with R 1 to form a bivalent radical of formula â€”CHâ•CHâ€”CHâ•CHâ€”; R 2 is hydrogen, hydroxy, C 1-6 alkyl, C 3-6 alkynyl or taken together with R 3 may form â•O; R 3 is a radical selected from â€”(CH 2 ) s â€”NR 8 R 9 (a-1), â€”Oâ€”Hâ€ƒâ€ƒ(a-2), â€”Oâ€”R 10 (a-3), â€”Sâ€”R 11 (a-4), or â€”Câ‰¡Nâ€ƒâ€ƒ(a-5), wherein s is 0, 1, 2 or 3; R 8 , R 10 and R 11 are each independently selected from â€”CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonylaminoC 1-6 alkyl, piperidinyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, thiophenylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindozolylpiperidinylC 1-6 alkyl, arylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl, and R 9 is hydrogen or C 1-6 alkyl; or R 3 is a group of formula â€”(CH 2 ) t â€”Zâ€ƒâ€ƒ(b-1), wherein t is 0, 1, 2 or 3; â€”Z is a heterocyclic ring system selected from wherein R 12 is hydrogen, halo, C 1-6 alkyl, aminocarbonyl, amino, hydroxy, aryl, C 1-6 alkylaminoC 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, arylC 1-6 alkyl, di(phenylC 2-6 alkenyl), piperidinyl, piperidinylC 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, arylC 1-6 alkylamino, morpholino, C 1-6 alkylimidazolyl, pyridinylC 1-6 alkylamino; and R 13 is hydrogen, piperidinyl or aryl; R 4 , R 5 and R 6 are each independently selected from hydrogen, halo, trihalomethyl, trihalomethoxy, C 1-6 alkyl, C 1-6 alkyloxy, amino, aminoC 1-6 alkyl, di(C 1-6 alkyl)amino, di(C 1-6 alkyl)aminoC 1-6 alkyloxy or C 1-6 alkyloxycarbonyl, or C 1-6 alkyl substituted with 1, 2 or 3 substituents independently selected from hydroxy, C 1-6 alkyloxy, or aminoC 1-6 alkyloxy; or when R 5 and R 6 are on adjacent positions they may taken together form a bivalent radical of formula â€”Oâ€”CH 2 â€”Oâ€ƒâ€ƒ(d-1), â€”Oâ€”(CH 2 ) 2 â€”Oâ€”â€ƒâ€ƒ(d-2), â€”CHâ•CHâ€”CHâ•CHâ€”â€ƒâ€ƒ(d-3), or â€”NHâ€”C(O)â€”NR 14 â•CHâ€”â€ƒâ€ƒ(d-4), wherein R 14 is C 1-6 alkyl; and aryl is phenyl, phenyl substituted with halo, C 1-6 alkyl or C 1-6 alkyloxy.