Patent ID: 7906661

Claim:
A process comprising: converting paclitaxel or paclitaxel containing material to docetaxel by protecting a compound of Formula (I): wherein R 1 is alkyl, alkenyl or aryl; and X, Y and Z are the same or different and independently hydroxy or protected hydroxyl, by: protecting one or more hydroxyl groups at the C-2′, C-7 and C-10 positions of the compound of Formula (I); and introducing a t-Boc group at the nitrogen of the amide group at the C-3′ position of the compound of Formula (I) to provide a C-2′, C-7 and C-10 and N-t-Boc protected paclitaxel derivative, and converting the one or more hydroxyl groups at the C-2′, C-7 and C-10 positions of the compound of Formula (I) to form docetaxel by removing the one or more hydroxy-protecting groups at the C-2, C-7 and C-10 positions, wherein the steps of protecting one or more hydroxy groups and introducing the t-Boc group comprises combining, in a one pot reaction, the compound of Formula (I) with a hydroxyl protecting group and a t-Boc agent.