Patent ID: 7943654

Claim:
A compound of formula (I): wherein A is an aryl or heteroaryl ring, on which the substituent —NHZR 5 is at the ortho position to the CONH linker; R 1 and R 2 are the same or different and, independently from each other, represent a hydrogen atom or a straight or branched C 1 -C 3 alkyl or R 3 is a hydrogen or halogen atom or a group selected from hydroxy, cyano, straight or branched C 1 -C 3 alkyl, C 1 -C 6 alkylamino, C 1 -C 6 di-alkylamino and C 1 -C 3 alkoxy; R 4 is a hydrogen or halogen atom or a group selected from hydroxy, straight or branched C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, (1-methyl-piperazin-4-yl), (morpholino-4-yl), (azetidin-1-yl)methyl, (pyrrolidin-1-yl)methyl, (piperidin-1-yl)methyl, (1-methyl-piperazin-4-yl)methyl, (morpholino-4-yl)methyl, (1-methyl-piperidin-4-yloxy)methyl, (C 1 -C 6 alkylamino)methyl and (C 1 -C 6 di-alkylamino)methyl; Z is direct bond, >C═O or —C(═O)NH—; R 5 is hydrogen or an optionally substituted group selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, aryl, heteroaryl and saturated heteroaryl; or optical isomers, tautomers, or pharmaceutically acceptable salts thereof.