Patent ID: 8735348

Claim:
A method of treating infection by HIV-1, the method comprising administering to a subject in need thereof a therapeutically effective amount of peptides derived from natural alphaS1, alphaS2, beta and kappa casein, and is prepared according to a preparation method comprising a) low-temperature proteolytic digestion of said natural alphaS1, alphaS2, beta and kappa casein in solution to obtain a casein proteolytic hydrolysate; b) cooling said casein proteolytic hydrolysate so as to inactivate said proteolytic enzymes; c) adjusting the pH of said casein protein hydrolysate to an acid pH; d) centrifuging said acidic casein protein hydrolysate, collecting the supernatant, filtering said supernatant and further acidifying said supernatant so as to precipitate proteins derived from natural casein; e) separating and collecting said precipitate; f) adjusting the pH of said precipitate to an alkaline pH so as to irreversibly inactivate said proteolytic enzymes; and g) adjusting the pH of said precipitate to below pH 9.