Patent ID: 8063028

Claim:
A compound according to formula I wherein: X 1 and X 2 are N; R 1 is fluorine or hydrogen; R 2 is hydrogen, halogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, or C 1-6 alkylsulfonyl; Ar is phenyl substituted with one to three groups independently selected in each occurrence from the group consisting of hydrogen, halogen, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl and C 3-7 cycloalkyl; R 3 is independently selected in each occurrence from the group consisting of: (i) CH 2 OH (ii) CH 2 O—C(═O)(CH 2 ) n CO 2 R 4 wherein n is 2 to 5; (iii) CH 2 O—C(═O)CH 2 OCH 2 CO 2 R 4 (iv) CH 2 OCOR 5 ; (v) CH 2 OC(═O)CHR 6 NH 2 ; (vi) C(═O)R 5 ; and, (vii) CH 2 OP(═O)(OH) 2 ; R 4 is hydrogen or C 1-10 alkyl; R 5 is hydrogen or C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 aminoalkyl, C 1-3 alkylamino-C 1-10 alkyl, C 1-3 dialkylamino-C 1-10 alkyl, C 2-10 alkenyl, C 3-7 cycloalkyl, C 1-6 alkoxy, C 1-10 aminoalkoxy, C 1-3 alkylamino-C 1-10 alkoxyl, C 1-3 dialkylamino-C 1-10 alkoxy, NR 7a R 7b , phenyl or pyridinyl said phenyl or pyridinyl ring optionally independently substituted with 1 to 3 substituents selected from the group consisting of halogen, C 1-10 alkyl, C 1-3 alkoxy, nitro and cyano; R 6 is C 1-6 alkyl or the side chain of a naturally occurring amino acid; R 7a and R 7b are independently hydrogen, C 1-6 alkyl or C 1-10 aminoalkyl, C 1-3 alkylamino-C 1-10 alkyl, C 1-3 dialkylamino-C 1-10 alkyl; or, a pharmaceutically acceptable salt thereof.