Patent ID: 7479497

Claim:
Method for inhibiting integrase and blocking viral replication in the stages preceding integration, and optionally at the level of this integration stage, for the treatment of retroviral pathologies, comprising administering to an animal or human in need thereof a 8-hydroxyquinoline 7-carboxylic acid derivative of formula III or a pharmaceutically acceptable salt thereof, wherein: X′ represents O, N, or an —(CH 2 ) n — alkyl chain in which n is equal to 0, 1 or 2; Z′ represents an aromatic ring which can comprise heteroatoms selected from the group consisting of O, N and S in substitution of the carbon atoms constituting said aromatic ring, wherein Z′ is substituted by 0-3 Rb′ groups; Rb′, if present, at each occurrence is independently selected from the group consisting of —OR, —COOR, —COR, —NRR′, —SR and CN; and R and R′, identical or different, are selected from the group consisting of H and a linear or branched alkyl chain with 1 to 4 carbon atoms.