Patent ID: 8030023

Claim:
Isolated nucleic acid encoding the heavy or light chain of an anti-DR5 antibody or a functional fragment thereof, wherein: (a) said heavy chain comprises the variable domain sequence of 16E2 antibody heavy chain of SEQ ID NO: 11, wherein G at position 33 of CDRH1 is substituted by A, N at position 53 of CDRH2 is substituted by Q, and L at position 102 of CDRH3 is substituted by Y, and (b) said light chain comprises the variable domain sequence of 16E2 antibody light chain of SEQ ID NO: 13, wherein Q at position 24 of CDRL1 is substituted by S, K at position 51 of CDRL2 is substituted by A, and R at position 91 of CDRL3 is substituted by A.