Patent ID: 8518928

Claim:
A compound of formula I: wherein: each B and E is independently —C(═O)NH—CH(R a )— or —C(═O)—NH—C(═O)—; A is a group of formula: D is a group of formula: each R 1 , R 2 , R 3 , R 4 , and R 5 is independently H, (C 1 -C 6 )alkyl, or (C 1 -C 6 )alkoxy, wherein each (C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy is optionally substituted with OH, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio, aryl, NR c R d , or —C(═O)NR c R d ; each R 6 , R 7 , and R 8 is independently H; or each R 6 and R 7 together with the atoms to which they are attached form a benzo ring and R 8 is H; or R 6 is H and R 7 and R 8 together with the atoms to which they are attached form a benzo ring; each X is independently NH, S, or O; each Z is independently N or CH; the bond represented by — is a single or a double bond; each R a is independently H, aryl, or (C 1 -C 6 )alkyl that is optionally substituted with OH, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylthio, aryl, NR e R f , or —C(═O)NR e R f ; each R c and R d is independently H or (C 1 -C 6 )alkyl; or R c and R d together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, morpholino, thiomorpholino, or azepino ring; and each R e and R f is independently H or (C 1 -C 6 )alkyl; or R e and R f together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, morpholino, thiomorpholino, or azepino ring; or a salt thereof.