Patent ID: 7153848

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, 2, or 3; A is a phenyl ring; B is a seven-membered carbocyclic ring containing 0 or 1 double bonds wherein said ring is optionally substituted with one, two, three, or four substitutes independently selected from alkoxy, alkoxycarbonyl, alkyl, carboxy, cyano, cycloalkyl, halo, hydroxy, hydroxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, NR 4 R 5 , (NR 4 R 5 )carbonyl, and oxo; R 1 is selected from —C(O)NR 4 R 5 , —CO 2 R 4 , 5-tetrazolyl, cyano, each R 2 is independently selected from alkoxy, alkoxyalkyl, alkyl, alkylamino, amino, arylalkoxy, aryloxy, dialkylamino, halo, haloalkoxy, haloalkyl, hydroxy, and hydroxyalkyl; R 3 is a five- to seven-membered cycloalkyl ring; R 4 is selected from hydrogen, alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, aryl, arylalkyl, and (NR 6 R 7 )alkyl; R 5 is selected from hydrogen, alkyl, hydroxyalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, aryl, arylalkyl, (NR 6 R 7 )alkyl, alkylcarbonyl, arylcarbonyl, (NR 6 R 7 )carbonyl, —S(O) 2 R 8 , —S(O) 2 NR 6 R 7 , or NR 4 R 5 taken together is pyrrolidinyl, piperidinyl, piperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl and is substituted with 0–2 substituents selected from the group consisting of alkyl, hydroxy, amino, alkylamino, dialkylamino, pyrrolidinyl, piperidinyl, and pyridinyl; R 6 and R 7 are independently selected from hydrogen, alkyl and cycloalkyl; R 8 is selected from alkyl, cycloalkyl, aryl, and heteroaryl; R 9 and R 10 are independently selected from hydrogen and alkyl; or R 9 and R 10 , together with the carbon atom to which they are attached, form a four- to seven-membered saturated ring optionally containing 1 or 2 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein said ring is optionally substituted with one or two substituents independently selected from alkoxycarbonyl, alkyl, and oxo; and R 11 is a five- or six-membered saturated, partially saturated, or aromatic ring containing 0, 1, 2, or 3 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein said ring is optionally substituted with one or two substituents independently selected from alkoxycarbonylalkenyl, alkoxycarbonylalkyl, alkyl, aryl, carboxy, carboxyalkenyl, carboxyalkyl, and heteroaryl, wherein said aryl and heteroaryl are further optionally substituted with one or two substituents independently selected from alkoxycarbonyl, alkoxycarbonylalkenyl, alkoxycarbonylalkyl, carboxy carboxyalkenyl, carboxyalkyl, and hydroxy; or a pharmaceutically acceptable salt or solvate thereof.