Patent ID: 8734850

Claim:
An oral medicinal product comprising a plurality of microcapsules with modified release of active principle(s), wherein at least one of said microcapsules individually comprises: a microparticle comprising at least one active principle having a solubility of less than 20 g/L (with the exclusion of carvedilol) and a swelling agent; and one coating on said microparticle making possible the modified release of the at least one active principle, said release being controlled by means of two distinct triggering mechanisms, wherein a first triggering mechanism is based on a variation in pH and wherein a second triggering mechanism is based on release of the at least one active principle after a predetermined period of residence in the stomach, wherein said coating confers on the microcapsules an in vitro dissolution behavior such that: at constant pH 1.4, the dissolution profile comprises a lag phase of less than or equal to 7 hours, and a change from pH 1.4 to pH 7.0 results in a release phase that begins without any lag time; wherein said swelling agent is capable of increasing the permeability of the coating for modified release of the active principle; wherein said swelling agent is selected from the group consisting of crosslinked polyvinylpyrrolidones, crosslinked carboxyalkylcelluloses, polacrilin potassium and mixtures thereof; and wherein the fraction by weight of the at least one active principle(s) released during the lag phase is less than or equal to 15% by weight per hour.