Patent ID: 7388026

Claim:
A prodrug of an analog of CC-1065, having three subunits linked by amide bonds, wherein the first subunit is a seco-CBI (cyclopropabenzindole) molecule represented by the following formula: wherein X is halogen, and wherein the second and third subunits together are represented by the formula (II): wherein R represents a linking group that enables linkage of said prodrug to a cell binding agent; R 1 -R 6 are each independently hydrogen, C 1 -C 3 linear alkyl, methoxy, hydroxyl, primary amino, secondary amino, tertiary amino, or amido; and R 7 is piperazine carbamate, 4-piperidino-piperidino carbamate or phosphate, and wherein the compound of formula (I) is covalently bonded the compound of formula (II) via the secondary amino group of the pyrrole moiety of the first subunit to the C-2 carboxyl of the second subunit.