Patent ID: 8168645

Claim:
A compound of formula (I): wherein X is NO 2 or —SO 2 —C(X′) 3 wherein X′ is H or halo; Z is a cycloalkyl, cycloalkenyl, aryl, heterocyclic or heteroaryl group; R 1 and R 2 are independently aryl, heteroaryl, —NR 5 R 6 , —CONR 5 R 6 , —O(CH 2 ) r aryl, —O(CH 2 ) r heteroaryl, —CO(CH 2 ) r aryl, —CO(CH 2 ) r heteroaryl, —CO 2 (CH 2 ) r aryl, —CO 2 (CH 2 ) r heteroaryl, —OCO(CH 2 ) r aryl, —OCO(CH 2 ) r heteroaryl, —S(CH 2 ) r aryl, —S(CH 2 ) r heteroaryl, —SO(CH 2 ) r aryl, —SO(CH 2 ) r heteroaryl, —SO 2 (CH 2 ) r aryl or —SO 2 (CH 2 ) r heteroaryl; R 3 is alkyl, alkenyl, —(CH 2 ) t cycloalkyl, —(CH 2 ) t cycloalkenyl, —(CH 2 ) t aryl, —(CH 2 ) t heterocyclyl or —(CH 2 ) t heteroaryl, wherein each cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl may be optionally substituted with alkyl, alkenyl, halo, nitro, haloalkyl, or phenyl optionally substituted with 1, 2 or 3 alkyl, alkenyl, alkoxy, halo or nitro groups; R 5 and R 6 are independently hydrogen, alkyl or alkenyl or R 5 and R 6 taken together with the nitrogen to which they are attached form a heterocyclic or heteroaryl ring; each R 7 is independently hydrogen, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl or acyl; each R 8 is independently hydrogen or halogen; each R 9 is independently hydrogen, —C 1-6 alkyl, —C 2-6 alkenyl or —C 2-6 alkynyl, t is 0 or an integer 1 to 6; and r is 0 or an integer 1 to 6; wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl group may be optionally substituted; or a pharmaceutically acceptable salt thereof.