Patent ID: 7115793

Claim:
A method for identifying an analyte that modulates expression of a sequence encoding a light-generating protein, wherein expression of said light-generating protein is mediated by transcription control elements derived from a mouse eosinophil peroxidase gene, in a living transgenic mouse, said method comprising providing a living transgenic mouse whose genome comprises an expression cassette comprising a polynucleotide having nucleotides 1 to 9,825 of SEQ ID NO:1 or a variant thereof that have at least 95% or greater identity to nucleotides 1–9,825 of SEQ ID NO:1 over the entire length of nucleotides 1–9,825, operably linked to a sequence encoding a light-generating protein, wherein the polynucleotide causes increased expression of the light-generating protein in eosinophils of the living transgenic mouse as compared to non-eosinophil blood cell-types; administering to the living transgenic living mouse said analyte; and monitoring expression of said light-generating protein wherein an effect on the level of expression of said light-generating protein indicates that the analyte affects expression mediated by transcription control elements derived from the mouse eosinophil peroxidase gene.