Patent ID: 8669248

Claim:
A compound having a structure according to the following formula, or a tautomer or pharmaceutically acceptable salt, or solvate thereof, wherein R 1 is H, halogen, CN, C 1-6 alkoxy, C 1-6 fluoroalkoxy, or C 1-6 alkyl; R 2A and R 2B are each H; each R 3A and R 3B is, independently, H, halogen, or C 1-6 alkyl; n is 1, 2, 3, or 4; R 4 is H, C 3-9 cycloalkyl or NR 4A R 4B ; R 4A and R 4B are each, independently, H or C 1-6 alkyl; X 1 is CH 2 , S, or SO; R 5 is a bicyclic heteroaryl selected from Substructures A, B, and D wherein (a) Substructure A is selected from wherein each of R 6A , R 6B , R 6C , and R 6D is, independently, H or C 1-6 alkyl, or R 6A and R 6B , or R 6C and R 6D , combine to form ═O or C 3-9 cycloalkyl, R 6E is H, C 1-6 alkyl, or alkC 3-9 cycloalkyl, R 6F is H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 1-6 alkylamino, or di(C 1-6 alkyl)amino; Y 1 and Y 2 are, independently, N or CR 6G , and R 6G is H, halogen, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, hydroxyC 1-6 alkyl, or C 1-6 alkoxy-C 1-6 alkyl; (b) Substructure B is selected from wherein R 7A is H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 1-6 alkylamino, or di(C 1-6 alkyl)amino, Y 3 and Y 4 are, independently, N or CR 7B , each X 2 , X 3 , and X 4 is, independently, N or CR 7C , each R 7B and R 7C is, independently, H, halogen, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, hydroxyC 1-6 alkyl, or C 1-6 alkoxy-C 1-6 alkyl, and wherein no more than 4 of Y 3 , Y 4 , X 2 , X 3 , and X 4 are N; (c) Substructure D has the following structure, wherein R 9A , R 9B , and R 9C are selected, independently, from H, halogen, CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, hydroxyC 1-6 alkyl, or C 1-6 alkoxy-C 1-6 alkyl.