Patent ID: 7122626

Claim:
A thienyl compound having formula Th-(D 1 )-(Y) m -B 5 (R 20 ) p and the pharmaceutically acid addition salts thereof, wherein Th is wherein each of R 1 , R 2 , and R 3 is H, F, Cl, Br, I, OH, NO 2 , a substituted or unsubstituted (C 1 –C 12 )alkyl group, or a substituted or unsubstituted (C 1 –C 12 )heteroalkyl group; with the provisos that, when m is 3 or greater, at least one of R 1 , R 2 , and R 3 is F, Cl, Br or I and that, when m is 2, at least one of R 2 and R 3 is F, Cl, Br, or I, but R 1 , R 2 , and R 3 being otherwise independently variable; D 1 is selected from the group consisting of a chemical bond, a substituted or unsubstituted (C 1 –C 6 )alkylene group, —S(═O)—, and —S(═O) 2 —; m is an integer ranging from 2 to 25, inclusive; each Y is independently selected from the group consisting of (a) moieties M 1 having the formula wherein each B 1 is independently selected from O, S, or NH; one of X 1 , X 2 , and X 3 is a ring vertex selected from the group consisting of —O—, —S—, and —NR 10 —, and the other two of X 1 , X 2 , and X 3 are ring vertices selected from the group consisting of ═N— and ═CR 11 —; each R 10 is independently H, a substituted or unsubstituted (C 1 –C 12 )alkyl group, or a substituted or unsubstituted (C 1 –C 12 )heteroalkyl group; and each R 11 is independently H, Cl, F, Br, I, OH, NO 2 , a substituted or unsubstituted (C 1 –C 12 )alkyl group, or a substituted or unsubstituted (C 1 –C 12 )heteroalkyl group; (b) moieties M 2 having the formula wherein n is 0 or 1; each B 2 is independently O, S, or NH; and each R 15 is independently H, OH, NH 2 , or F; and (c) moieties M 3 having the formula wherein each B 3 is independently O, S, or NH and each L is independently a divalent moiety separating —NH— and —(C═B 3 )— by 3 or 4 atoms; B 5 is N or O; p is 1 if B 5 is O and 2 if B 5 is N; and each R 20 is independently H, a substituted or unsubstituted (C 1 –C 12 )alkyl group or a substituted or unsubstituted (C 1 –C 12 )heteroalkyl group; with the proviso that at least one of R 1 , R 2 , R 3 , R 10 , R 11 , and R 20 contains at least one basic group having a pK b of 12 or less and that at least two Y's are moieties M 1 .