Patent ID: 8911422

Claim:
A method for injecting a physiologically active substance to a patient's skin with a micro-needle device, comprising: determining a suitable injection site on a patient in need of administration of the physiologically active substance, preparing or obtaining a micro-needle device with micro-needles installed on a base plate, wherein the length of the micro-needles is 300 to 550 μm, a coating agent containing the physiologically active substance is coated at a part of the micro-needles, and a coating range of the coating agent is 100 to 230 μm in height including the top of the micro-needles, and injecting the physiologically active substance at the injection site by applying, at least twice, a load due to the energy of 0.2 to 0.7 J/cm 2 to the micro-needle device with the micro-needles in contact with the patient's skin.