Patent ID: 7090832

Claim:
A pharmaceutical composition comprising from about 1% to about 99% by weight of the pharmaceutical composition of at least one active pharmaceutical agent selected from the group consisting of antacid agents, acid secretion prevention agents, bismuth containing agents and mixtures thereof and from about 1% to about 99% by weight of the pharmaceutical composition excipients comprising at least one cooling agent in spray dried form, wherein the cooling agent comprises a) N-substituted p-menthane-3-carboxamide of the formula: where R′, when taken separately, is hydrogen or an aliphatic radical containing up to 25 carbon atoms; and R″, when taken separately is hydroxy, or an aliphatic radical containing up to 25 carbon atoms, with the proviso that when R′ is hydrogen R″ may also be an aryl radical of up to 10 carbon atoms and selected from the group consisting of substituted phenyl, phenalkyl, substituted phenalkyl, naphthyl, substituted naphthyl, and pyridyl; and R′ and R″, when taken together with the nitrogen atom to which they are attached, represent a cyclic or heterocyclic group of up to 25 carbon atoms, b) menthyl acetate wherein the menthyl acetate and the N-substituted p-menthane-3-carboxamide act synergistically to provide a cooling effect, and c) solubilizer of mixed esters of capric and acrylic acids esterified on glycerin wherein said solubilizer is present in an amount sufficient to prevent the N-substituted p-methane-3-carboxamines from crystallizing out of solution during the spray drying process.