Patent ID: 8614254

Claim:
A method of treating a thalamocortical dysrhythmia disorder in a mammal in need thereof, the disorder resulting from abnormal hyperpolarization of a thalamic neuron having a protractedly activated Ca v 3 channel and an increased low threshold calcium current, the disorder being Migraine, restless leg syndrome, obsessive compulsive disorder, Tourette's disorder, autism, or Asperger's syndrome, and not tremor or Parkinson's tremor, the method comprising inhibiting the Ca v 3 calcium channel by administering to the mammal an inhibitor which binds to the Ca v 3 calcium channel, thereby reducing the low threshold calcium current in and hyperpolarization of the neuron, wherein the Ca v 3 calcium channel inhibitor is a C 2 -C 10 alkyl alcohol, a lipophilic molecule with a partition coefficient at least 5% that of a C 2 -C 10 alkyl alcohol, or mixtures thereof.