Patent ID: 7892542

Claim:
An isolated human anti-idiotypic antibody Fab- or scFv-fragment, which mimics Her-2/neu tumor associated antigen, and which comprises CDR1H, CDR1L, CDR2H, CDR2L, CDR3H and CDR3L, wherein the amino acid sequence of CDR1H consists of the sequence SYAMS (SEQ ID No: 15), wherein the amino acid sequence of CDR1L consists of the sequence QGDSLRSYYAS (SEQ ID No: 16), wherein the amino acid sequence of CDR2H consists of the sequence SGGTYYADSVKG (SEQ ID No: 17), wherein the amino acid sequence of CDR2L consists of the sequence GKNNRPS (SEQ ID No: 18), and (i) wherein the amino acid sequence of CDR3H consists of the sequence SEQ ID No: 3 when the amino acid sequence of CDR3L consists of the sequence SEQ ID No: 4, or (ii) wherein the amino acid sequence of CDR3H consists of the sequence SEQ ID No: 5 when the amino acid sequence of CDR3L consists of the sequence SEQ ID No: 6, wherein said fragment binds trastuzumab F(ab′) 2 .