Patent ID: 6969593

Claim:
A method for the selective survival or selective growth of a bacterial target cell comprising the steps of: a) contacting the bacterial target cell with a conjugate compound A-B, wherein A is a selective antibody or antibody derivative recognizing the target cell and B is an enzyme able to inactivate an antibiotic, wherein said antibiotic inhibits the growth of the bacterial target cell; and b) contacting the bacterial target cell with the antibiotic; wherein said antibiotic is a Î²-lactam antibiotic, chloramphenicol, or an aminoglycoside, and/or wherein the enzyme is a Î²-lactamase, a chloramphenicol-acetyltransferase, an aminoglycoside-N-acetyltransferase, an aminoglycoside-O-nucleotidyltransferase, or an aminoglycoside-Q-phosphotransferase.