Patent ID: 6994871

Claim:
A controlled release pharmaceutical formulation consisting essentially of: (A) a compressed matrix core consisting of: (i) 10 to 50 weight percent based on the total weight of the matrix core of a decongestant or pharmaceutically acceptable salt thereof; (ii) 50 to 90 weight percent based on the total weight of the matrix core of a hydrogel forming polymer “selected from the group consisting of hydroxypropyl methylcellulose, carboxymethylcellulose calcium, carboxymethylcellulose sodium, guar gum, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, acrylic acid crosslinked with polyalkenyl ethers or divinyl glycol, sodium alginate and polyethylene oxide”; (iii) 0 to 20 weight percent based upon the total weight of the matrix core of a filler selected from lactose, starch, dextrose or sucrose; (iv) 0 to 5 weight percent based on the total weight of the matrix core of a glidant; (v) 0 to 10 weight percent based on the total weight of the matrix core of one or more lubricants; (B) an immediate release coating on said compressed matrix core which consists essentially of: (i) 0.01 to 10 weight percent based on the total weight of the formulation of an antihistamine (ii) 0 to 20 weight percent based upon the total weight of the formulation of a pharmaceutically acceptable binder which allows for immediate release of the antihistamine (iii) 0 to 10 weight percent based on the total weight of the formulation of a lubricant; and (iv) 0 to 10 weight percent based on the total weight of the formulation of an antiadherent; and (C) optionally a polishing agent or color coating that coats the immediate release coating.