Patent ID: 8044210

Claim:
A method for preparing a pharmaceutically acceptable salt of 2,4,6-trimethyl-3-hydroxypyridine with a lower dicarboxylic acid, of formula (I) wherein X is selected from the group consisting of a single bond, —CH 2 —, —CH 2 CH 2 —, and —CH 2 CH(OH)—said salt having antioxidant, geroprotective and anti-ischemic activity, said method comprising: reacting equimolar amounts of 2, 4, 6-trimethyl-3-hydroxypyridine and a dicarboxylic acid in a solution of a lower alcohol at boiling temperature, treating the resulting reaction mixture with an organic solvent; and, optionally, maintaining the reaction mixture for 2-5 h at 10-15° C.