Patent ID: 7022703

Claim:
A compound of Formula (I): wherein: A is (C 5-6 )cycloalkyldiyl, cyclic heteroalkyldiyl, aryldiyl or heteroaryldiyl; B is aryldiyl or heteroaryldiyl; E is aryldiyl or heteroaryldiyl; R 1 is (C 3-8 )cycloalkyl-(R 8 ) q , cyclic heteroalkyl-(R 9 ) q , aryl-(R 8 ) q , heteroaryl-(R 9 ) q or NR 5 R 6 ; R 5 is hydrogen, (C 1-12 )alkanyl-R 7 , C(O)H, C(O)—(C 1-12 )alkanyl-R 7 , CO 2 H, C(O)O—(C 1-12 )alkanyl-R 7 , (C 3-8 )cycloalkyl-(R 8 ) q , cyclic heteroalkyl-(R 9 ) q , aryl-(R 8 ) q or heteroaryl-(R 9 ) q ; wherein cyclic heteroalkyl-(R 9 ) q and heteroaryl-(R 9 ) q are attached to the nitrogen atom of NR 5 R 6 via a ring carbon atom; R 6 is hydrogen or (C 1-8 )alkanyl-R 7 ; R 7 is hydrogen, (C 1-8 )alkoxy-(R 10 ) s , C(O)H, C(O)—(C 1-8 )alkanyl-(R 10 ) s , C(O)—R a , CO 2 H, C(O)O—(C 1-8 )alkanyl-(R 10 ) s , C(O)O—R a , OC(O)—(C 1-8 )alkanyl-(R 10 ) s , OC(O)—R a , NH 2 , NH(C 1-8 alkanyl-(R 10 ) s ), N(C 1-8 alkanyl-(R 10 ) s ) 2 , cyano, (halo) 1-3 , hydroxy or R a ; R a is (C 3-8 )cycloalkyl-(R 11 ) q , cyclic heteroalkyl-(R 12 ) q , aryl-(R 11 ) q or heteroaryl-(R 12 ) q ; (R 8 ) q is hydrogen, (C 1-8 )alkanyl-(R 10 ) s , (C 1-8 )alkoxy-(R 10 ) s , C(O)H, C(O)—(C 1-8 )alkanyl-(R 10 ) s , CO 2 H, C(O)O—(C 1-8 )alkanyl-(R 10 ) s , NH 2 , NH(C 1-8 alkanyl-(R 10 ) s ), N(C 1-8 alkanyl-(R 10 ) s ) 2 or halogen; (R 9 ) q is hydrogen, (C 1-8 )alkanyl-(R 10 ) s , C(O)H, C(O)—(C 1-8 )alkanyl-(R 10 ) s , CO 2 H or C(O)O—(C 1-8 )alkanyl-(R 10 ) s when attached to a nitrogen atom; wherein (R 9 ) q is hydrogen, (C 1-8 )alkanyl-(R 10 ) s , (C 1-8 )alkoxy-(R 10 ) s , C(O)H, C(O)—(C 1-8 )alkanyl-(R 10 ) s , CO 2 H, C(O)O—(C 1-8 )alkanyl-(R 10 ) s , NH 2 , NH(C 1-8 alkanyl-(R 10 ) s ), N(C 1-8 alkanyl-(R 10 ) s ) 2 or halogen when attached to a carbon atom; (R 10 ) s is hydrogen, (C 1-8 )alkoxy, NH 2 , NH(C 1-8 alkanyl), N(C 1-8 alkanyl) 2 , (halo) 1-3 or hydroxy; (R 11 ) q is hydrogen, (C 1-8 )alkanyl, (C 1-8 )alkoxy, NH 2 , NH(C 1-8 alkanyl), N(C 1-8 alkanyl) 2 or halogen; (R 12 ) q is hydrogen or (C 1-8 )alkanyl; R 2 is hydrogen, (C 1-8 )alkanyl-R 7 , (C 1-8 )alkoxy-R 7 , C(O)H, C(O)—(C 1-8 )alkanyl-R 7 , CO 2 H, C(O)O—(C 1-8 )alkanyl-R 7 , NH 2 , NH(C 1-8 alkanyl-R 7 ), N(C 1-8 alkanyl-R 7 ) 2 , cyano, halogen, hydroxy or R a ; R 3 and R 4 are independently hydrogen, (C 1-8 )alkanyl-R 7 , C(O)H, C(O)—(C 1-8 )alkanyl-R 7 , CO 2 H, C(O)O—(C 1-8 )alkanyl-R 7 , (C 3-8 )cycloalkyl-(R 8 ) q or aryl-(R 8 ) q when attached to a nitrogen atom; wherein R 3 and R 4 are independently hydrogen, (C 1-8 )alkanyl-R 7 , (C 1-8 )alkoxy-R 7 , C(O)H, C(O)—(C 1-8 )alkanyl-R 7 , CO 2 H, C(O)O—(C 1-8 )alkanyl-R 7 , NH 2 , NH(C 1-8 alkanyl-R 7 ), N(C 1-8 alkanyl-R 7 ) 2 , cyano, halogen, hydroxy, (C 3-8 )cycloalkyl-(R 8 ) q , cyclic heteroalkyl-(R 9 ) q , aryl-(R 8 ) q or heteroaryl-(R 9 ) q when attached to a carbon atom; q is 1, 2, 3, 4 or 5; and, s is 1 or 2; and enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.