Patent ID: 7598291

Claim:
A composition for topical application to the skin to enhance collagen synthesis consisting of: proanthocyanidin as an antioxidant compound, in a quantity of from about 0.3% (w/w) to about 2.0% (w/w); (b) an organic penetrant selected from the group consisting of lower alkyl diols, C 10 -C 20 fatty acids and esters thereof, and C 4 -C 20 optionally substituted aliphatic alcohols in a quantity of from of about 1.0% (w/w) to about 15.0% (w/w); (c) a mixture of essential amino acids consisting of; (i) from about 5% to about 20% of isoleucine; (ii) from about 5% to about 20% of leucine; (iii) from about 10% to about 25% of lysine; (iv) from about 2% to about 35% of methionine; (v) from about 5% to about 20% of phenylalanine; (vi) from about 5% to about 25% of threonine; (vii) from about 5% to about 20% of tryptophan; (viii) from about 10% to about 25% of valine; (ix) from about 5% to about 20% of histidine; and (x) from about 5% to about 20% of arginine, the mixture being present in a quantity sufficient to enhance collagen synthesis in the skin in an individual to which the composition is applied; and (d) a topical pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier consists of: (i) water; (ii) propylene glycol; (iii) carbopol; (iv) a surface coated starch polymer; (v) octyl palmitate; vi) isopropyl palmitate; (vii) silicone fluid; (viii) a mixture of glyceryl stearate and PEG-100 stearate; (ix) cetearyl alcohol; (x) triethanolainine; (xi) caprylic/capric triglyceride; (xii) caprylic/capric stearyl triglyceride; (xiii) natural lavender oils; (xiv) natural chamomile oils; (xv) methylparabern; (xvi) propylparaben; and (xvii) diazolidinyl urea: such that the composition enhances the synthesis of collagen and proteoglycans in skin fibroblasts of an individual to which the composition is applied by the action of the antioxidant compound and the mixture of essential amino acids.