Patent ID: 8680095

Claim:
A method of treating a neurodegenerative disease involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs in a patient in need thereof, comprising the step of administering to said patient a therapeutically effective amount of a compound having formula (I): wherein: a represents a single bond or a double bond; b represents a single bond or a double bond, provided that when a is a single bond, then b is a double bond, and when a is a double bond, then b is a single bond; R 3 is absent when a is a double bond, or, when a is a single bond, R 3 is chosen from the groups consisting of: alkyl, cycloalkyl, aryl and heterocycle radicals, said alkyl, cycloalkyl, aryl and heterocycle radicals being substituted or unsubstituted; R 4 is absent when b is a double bond, or, R 4 is H when b is a single bond; R 5 is chosen from the group consisting of: H, (C 1 -C 12 )alkyl, OH, and (C 1 -C 12 )alkoxy, R 6 is chosen from the group consisting of: H, halogen, CN, OH, (C 1 -C 12 )alkoxy, (C 1 -C 12 )alkyl, (C 6 -C 30 )aryl, heteroaryl, CO 2 R, wherein R is an alkyl group comprising from 1 to 12 carbon atoms, NR a R b , R a and R b being each independently chosen from: H, alkyl, aralkyl, aryl, cycloalkyl, and heterocycle groups, said alkyl, aralkyl, aryl, cycloalkyl, and heterocycle groups being substituted or unsubstituted, or R a and R b forming together with the nitrogen atom carrying them a substituted or unsubstituted heterocycle group; and a radical of formula: —X′—(CH 2 ) n′ —NR′ 1 R′ 2 , wherein: X′ is chosen from: CH 2 , O, NH, CO, CH 2 OCO, and NHCO; n′ is 0, 1 or 2; R′ 1 and R′ 2 are each independently chosen from H, alkyl, aralkyl, aryl, cycloalkyl and heterocycle groups, said alkyl, aralkyl, aryl, cycloalkyl, and heterocycle groups being substituted or unsubstituted, or R′ 1 and R′ 2 may form together with the nitrogen atom carrying them a substituted or unsubstituted heterocycle group; X is chosen from: CH 2 , O, NH, CO, CH 2 OCO, and NHCO; n is 0, 1 or 2; R 1 and R 2 are each independently chosen from H, alkyl, aralkyl, aryl, cycloalkyl and heterocycle groups, said alkyl, aralkyl, aryl, cycloalkyl and heterocycle groups being substituted or unsubstituted, or R 1 and R 2 may form together with the nitrogen atom carrying them a substituted or unsubstituted heterocycle group; or its pharmaceutically acceptable salts, hydrates or hydrated salts or its polymorphic crystalline structures, racemates, diastereisomers or enantiomers, with the exclusion of the compounds having the following formula: wherein: R 6 is H and R 8 is —CH 2 —NEt 2 ; R 6 is OH and R 8 is chosen from: —CH 2 —NEt 2 , —CH 2 —NHEt, R 6 is OMe and R 8 is —CH 2 —NEt 2 or