Patent ID: 7427679

Claim:
A compound having the structure (III) wherein: O and H represent oxygen and hydrogen, respectively, R 1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, substituted lower alkyl, or alkoxy, one of R 2 or R 3 is a hydroxyl protecting group; and the other of R 2 or R 3 is a reactive group capable of reacting with a reactive site hydroxyl of a nucleoside moiety to produce either a phosphite diester or a phosphite triester internucleotide linkage, Base is a heterocyclic base having an exocyclic amine group, and Tram is an abbreviation representing an exocyclic amine group protected by a triaryl methyl group having the structure (V) wherein the broken line represents a bond to the amino nitrogen of the exocyclic amine group, and R 4 , R 5 and R 6 are independently selected from unsubstituted or substituted aryl groups, provided that at least one of R 4 , R 5 , and R 6 is an unsubstituted or substituted furanyl group.