Patent ID: 8603520

Claim:
A method for treating conditions caused by inappropriate gastric acid secretion, said method comprising orally administering a capsule to a subject in need of such treatment, wherein the capsule comprises: (i) a first separate and distinct population of a pharmaceutical active comprising an acid labile drug and a disintegrating agent, wherein the acid labile drug is releasable at a first rate in a rapid or gradual manner in the stomach, wherein the first population is selected from the group consisting of: a population of separate and distinct beads, a population of separate and distinct pellets, a population of separate and distinct tablets, a population of separate and distinct granules, and any combination thereof; (ii) a second separate and distinct population of a pharmaceutical active comprising a pharmaceutical active substance and a sustained release agent, wherein the pharmaceutical active substance is releasable at a second rate in at least one of a delayed and sustained manner between the duodenum and lust past the ileocecal junction, wherein the second population is selected from the group consisting of: a population of separate and distinct beads, a population of separate and distinct pellets, a population of separate and distinct tablets, a population of separate and distinct granules, and any combination thereof; and (iii) a separate and distinct population of a basic substance that is rapidly released in the stomach and increases the stomach pH to more than about 4 and less than about 7 in less than about 1 hour, wherein the population of the basic substance excludes said acid labile drug and said pharmaceutical active substance, the population of the basic substance being selected from the group consisting of: a population of separate and distinct beads, a population of separate and distinct pellets, a population of separate and distinct tablets, a population of separate and distinct granules, and any combination thereof.