Patent ID: 8828416

Claim:
A medical device comprising: an implantable structure; a basecoat matrix, including a combination of rapamycin and topotecan, in therapeutic dosages, incorporated in a poly(vinylidinefluoride) (PVDF)/hexafluoropropylene (HFP) copolymer, the basecoat matrix being affixed to the surface of the implantable medical device, the concentration of rapamycin being in a range from log −9.8 M to log −7.7 M and the concentration of topotecan being about 300 nanomolar, the topotecan potentiating the anti-proliferative activity of rapamycin; and a topcoat affixed to the basecoat matrix for controlling the elution rate of the rapamycin and the topotecan, the topcoat comprising a butyl methacrylate (BMA) polymer, wherein the topcoat and the basecoat are separate and distinct layers and wherein the (PVDF)/(HFP) copolymer and the BMA polymer are immiscible and chemically incompatible polymers such that the basecoat matrix and topcoat do not blend and are affixed as separate and distinct layers upon each other to create a physical and chemical barrier to the elution of the rapamycin.