Patent ID: 8299075

Claim:
A method of treating epilepsy comprising administering an anti-convulsive and a compound of formula I: wherein q is 0 or 1; W is O; X is CO; Z is O; R1 is selected from the group consisting of halogen, cyano, C 1-6 -alk(en/yn)yl, C 3-8 -cycloalk(en)yl, C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl, halo-C 1-6 -alk(en/yn)yl, halo-C 3-8 -cycloalk(en)yl, halo-C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl, C 1-6 -alk(en/yn)yloxy, C 3-8 -cycloalk(en)yloxy and C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yloxy; R2 is selected from the group consisting of halogen, cyano, C 1-6 -alk(en/yn)yl, C 3-8 -cycloalk(en)yl, C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl, halo-C 1-6 -alk(en/yn)yl, halo-C 3-8 -cycloalk(en)yl, halo-C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl, C 1-6 -alk(en/yn)yloxy, C 3-8 -cycloalk(en)yloxy, C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yloxy, optionally substituted phenyl and optionally substituted pyridyl; wherein phenyl and pyridyl are optionally substituted with one or more substituents independently being halogen, C 1-6 -alk(en/yn)yl, C 3-8 -cycloalk(en)yl or C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl; R3 is selected from the group consisting of C 1-10 -alk(en/yn)yl, C 3-8 -cycloalk(en)yl, C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl, Ar—C 1-6 -alk(en/yn)yl, Ar—C 3-8 -cycloalk(en)yl, Ar—C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl and Ar; and each of R4, R5, R6 and R7 is independently selected from the group consisting of hydrogen and Ar; wherein Ar is selected from the group consisting of phenyl, naphthyl, pyridine, optionally substituted thiophene, furan, thiazole, quinoline, indole, 2,3-dihydro-benzofuran, pyrimidine, pyrrole and oxazole; in which the Ar is optionally substituted with one or more substituents independently being hydroxy, halogen, C 1-6 -alk(en/yn)yl, C 3-8 -cycloalk(en)yl, C 3-8 -cycloalk(en)yl-C 1-6 -alk(en/yn)yl, halo-C 1-6 -alk(en/yn)yl, C 1-6 -alk(en/yn)yloxy, C 3-8 -alk(en/yn)yloxy, acyl, nitro or cyano, —CO—NH—C 1-6 -alk(en/yn)yl, —CO—N(C 1-6 -alk(en/yn)yl 2 , —NH 2 , —NH—C 1-6 -alk(en/yn)yl, —N(C 1-6 -alk(en/yn)yl) 2 , —S—C 1-6 -alk(en/yn)yl, —SO 2 —C 1-6 -alk(en/yn)yl, —SO 2 N(C 1-6 -alk(en/yn)yl) 2 and —SO 2 NH—C 1-6 -alk(en/yn)yl; or two adjacent substituents may together with the aromatic group to which they are attached form a 4-8 membered ring, which optionally contains one, two or three heteroatoms; when Ar is substituted with CO—NH—C 1-6 -alk(en/yn)yl or CO—N(C 1-6 -alk(en/yn)yl) 2 , then the carbon atom of the CO group is attached to Ar; when Ar is substituted with NH 2 , NH—C 1-6 -alk(en/yn)yl or N(C 1-6 -alk(en/yn)yl) 2 , then the nitrogen atom is attached to Ar; when Ar is substituted with —S—C 1-6 -alk(en/yn)yl, —SO 2 —C 1-6 -alk(en/yn)yl), —SO 2 N(C 1-6 -alk(en/yn)yl) 2 or —SO 2 NH—C 1-6 -alk(en/yn)yl then the sulphur atom is attached to Ar; or a salt thereof.