Patent ID: 7632486

Claim:
A method of diagnosing amelioration and/or exacerbation of metastasis of malignant tumor to bone in a patient with a cancer disease, using markers for bone formation that reflect the activity of osteoblasts and markers that reflect the activity of osteoclasts, 1) wherein the markers that reflect the activity of osteoblasts are a) a marker associated with the phase of calcification, and b) a marker associated with the phase of osteoblasts proliferation and/or matrix formation, 2) wherein the marker that reflects the activity of osteoclasts is a marker associated with osteoclasts targeted to evaluation of worsening of the disease, whereby the amelioration of bone metastasis or therapeutic effect and the degree of the exacerbation of bone metastasis are diagnosed correctly by monitoring said two markers, one associated with osteoblasts and targeted to evaluation of therapeutic effect, and the other associated with osteoclasts and targeted to evaluation of worsening of the disease.