Patent ID: 8383865

Claim:
A method of treating a subject with Alzheimer's disease, the method comprising administering to the subject an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is —OH or —O—(C 1 -C 6 )alkyl; each R 2 and R 3 are independently selected from the group consisting of —OH, —O(C 1 -C 6 )alkyl, halo, —C(Y) 3 and —OP; Y is a halogen; P is selected from the group consisting of —C(O)—(C 1 -C 6 )alkylene—N(R 5 )(R 6 ), —C(O)—N(R 7 )—(C 1 -C 6 )alkylene-COOH, —C(O)—(C 1 -C 6 )alkylene-heterocyclyl and —C(O)—(C 1 -C 6 )alkylene-aryl; each R 4 R 5 and R 6 are independently selected from —H and (C 1 -C 6 )alkyl; R 7 is —H or (C 1 -C 4 )alkyl; X − is an anion; n is an integer from 1 to 4; m is an integer from 1 to 5; and p is an integer from 1 to 5, wherein each alkyl is optionally substituted with one or more substituents independently selected from —OH, —O—(C 1 -C 4 )alkyl, —COOH, —O—C(O)—(C 1 -C 4 )alkyl, —N(R 7 ) 2 and — (R 7 ) 3 X − , R 2 and R 3 are the same, and m and p are the same.