Patent ID: 7935702

Claim:
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: Y and Z are each N; R 2 is hydrogen or C 1 -C 6 alkyl; R 7 is hydrogen; Ar is 2-pyridyl which is: (i) substituted at one ring carbon atom meta or para to the point of attachment with one substituent chosen from halogen, cyano, nitro and groups of the formula LR a , and (ii) optionally substituted at any other ring carbon atom(s) with an additional 1-3 substituents independently chosen from halogen, cyano, nitro and groups of the formula LR a ; Ar 2 is 2-pyridyl substituted with from 0 to 6 substituents independently chosen from oxo and groups of the formula LR a ; L is independently selected at each occurrence from a single covalent bond, O, C(═O), OC(═O), C(═O)O, OC(═O)O, S(O) m , N(R x ), C(═O)N(R x ), N(R x )C(═O), N(R x )S(O) m , S(O) m N(R x ) and N[S(O) m R w ]S(O) m ; wherein m is independently selected at each occurrence from 0, 1 and 2; R x is independently selected at each occurrence from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkanoyl and C 1 -C 6 alkylsulfonyl; and R W is C 1 -C 6 alkyl; R a is independently selected at each occurrence from: (i) hydrogen, such that R a is not hydrogen if L is a bond; and (ii) C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, (C 3 -C 8 cycloalkyl)C 0 -C 6 alkyl, C 1 -C 8 haloalkyl, C 2 -C 8 alkyl ether, mono-and di-(C 1 -C 8 alkyl)amino and (3-to 10-membered heterocycle)C 0 -C 6 alkyl, each of which is substituted with from 0 to 6 substituents independently selected from R b ; and R b is independently chosen at each occurrence from hydroxy, halogen, amino, aminocarbonyl, aminosulfonyl, cyano, nitro, oxo, COOH, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 alkoxy, C 1 -C 8 alkylthio, C 1 -C 8 alkanoyl, C 2 -C 8 alkanoyloxy, C 1 C 8 alkoxycarbonyl, C 2 -C 8 alkyl ether, C 1 -C 8 hydroxyalkyl, C 1 -C 8 haloalkyl, mono- or di-(C 1 -C 6 alkyl)aminoC 0 -C 4 alkyl, C 1 -C 8 alkylsulfonyl, mono- or di- (C 1 -C 6 alkyl)aminocarbonyl, mono-or di-(C 1 -C 6 alkyl)aminosulfonyl, (3- to 7-membered carbocycle)C 0 -C 8 alkyl and (4- to 7-membered heterocycle)C 0 -C 8 alkyl.