Patent ID: 8648068

Claim:
A compound of Formula (I) wherein X is CH or N, R 1 is H, halogen, CN, CH 3 or CF 3 , R 2 is a group selected from wherein the group may be substituted at the nitrogen atom by —SO 2 —(C 1-3 alkyl), —CO—(C 1-3 alkyl), —CO—(CH 2 ) n —O—(C 1-3 alkyl), —CO—(CH 2 ) n —N(C 1-3 alkyl) 2 , C 1-4 alkyl, —(CH 2 ) n —CF 3 , —(CH 2 ) n —CHF 2 , —(CH 2 ) n —OH, —(CH 2 ) n —O—(C 1-3 alkyl), —(CH 2 ) n —CN, and wherein it may be substituted on a carbon atom by a —CH 2 OH group, wherein n is 1 or 2, and wherein the group may be substituted at the nitrogen atom by linear or branched C 1-4 alkyl, —(CH 2 ) n —CF 3 , —(CH 2 ) n —CHF 2 , —(CH 2 ) n —OH, —(CH 2 ) n —O—(C 1-3 alkyl), —(CH 2 ) n —CN, —(CH 2 ) n —CO—N(C 1-3 alkyl) 2 , —SO 2 —(C 1-3 alkyl), —CO—(C 1-3 alkyl), —CO 2 (C 1-4 alkyl), —CO 2 —(CH 2 ) p —CF 3 , —CO 2 —(CH 2 ) n —O—(C 1-3 alkyl), —CO 2 —(CH 2 ) n —CO—N(C 1-3 alkyl) 2 , wherein n is 1 or 2, R 3 is a C 1-2 alkyl group, and R 4 is —COOH, —CO 2 —(C 1-3 alkyl), —CO 2 —(CH 2 ) n —N(C 1-3 alkyl) 2 , —CONH 2 , —CO—NHR 5 , —CO—NH—(CH 2 ) p —R 6 , —CO—NH—(CH 2 ) m —R 7 , —CO—N(CH 3 )—(CH 2 ) m —R 7 , CO—N(CH 3 )—(CH 2 )-cyclohexyl, R 5 is —CN, —OH, linear or branched C 1-6 alkyl, —O(C 1-3 alkyl), C 3-6 cycloalkyl, —SO 2 —(C 1-3 alkyl); pyrazolyl optionally substituted by methyl; or piperidinyl optionally substituted by methyl, wherein the C 3-6 cycloalkyl group may be substituted by —NH 2 , —OH or —OCH 3 ; R 6 is —C(CH 3 ) 2 Cl; —C(CH 3 ) 2 OH; —CHC 3-6 cycloalkyl, which is optionally substituted by OH; imidazolyl, which is optionally substituted by methyl; pyrrolidinyl, which is optionally substituted by C 1-3 alkyl or by an oxo group; tetrahydrofuranyl; tetrahydropyranyl; phenyl, which is optionally substituted by one or two —F, —Cl, —CN, —OH, C 1-3 alkyl or —O(C 1-3 alkyl); naphthyl; pyridinyl; furanyl; thiophenyl; oxazolyl; thiazolyl; pyrazolyl; morpholinyl, which is optionally substituted by methyl; benzothiophenyl; —CO-phenyl; or —SO 2 —N(C 1-3 alkyl) 2 , and R 7 is F, —OH, —OCF 3 , —O—(C 1-3 alkyl), —O-phenyl, —O—(CH 2 ) m —OH, —N(C 1-3 alkyl) 2 , —NH-phenyl, piperidinyl, pyrrolidinyl, azetedinyl or aziridinyl, wherein said NH-phenyl, piperidinyl, pyrrolidinyl, azetedinyl and aziridinyl groups at R 7 may each be substituted at the nitrogen atom by C 1-3 alkyl, wherein p is 1, 2 or 3, m is 2 or 3, and * indicates the point of attachment of the R group to the rest of the molecule, or a tautomer, enantionmer, diastereomer or a salt thereof.