Patent ID: 8362244

Claim:
A method for producing a nucleoside derivative of formula (2): wherein R 2 is NH 2 or OH, comprising reducing a nucleoside of formula (1): wherein R 1 is hydrogen or a protective group, R 2 is NH 2 or OH, R 3 is an acyl group, and X is a chlorine or bromine atom, in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of: (A) a homogeneously supported catalyst where the specific surface area of the noble metal as determined by the CO gas adsorption method is 95.0 m 2 /g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal as determined by the CO gas adsorption method is 56.0 m 2 /g or more and the particle size of the noble metal is 8.0 nm or less, to obtain the nucleoside derivative of formula (2).