Patent ID: 7425651

Claim:
A compound of Formula I: wherein: n is 0, 1, or 2; R 1 is OH, C 1 to C 12 alkoxy, C 1 to C 12 substituted alkoxy, aryloxy, O-glucosyl or imino; R 2 is OH, C 1 to C 12 alkoxy, C 1 to C 12 substituted alkoxy, O-glucosyl, oxo, alkyl or imino; R 3 , R 4 , R 5 , R 6 , R 7 , A, B, C, D and E are each independently H, halogen selected from the group consisting of bromo, iodo, fluoro and chloro, OH, C 1 to C 12 alkoxy, C 1 to C substituted alkoxy, aryloxy, O-glucosyl, C 1 to C 12 alkyl or C 1 to C 12 substituted alkyl; provided that at least one of R 6 and R 7 is selected from the group consisting of bromo, iodo, fluoro and chloro; wherein R 1 and R 2 , or R 1 and R 4 may form together a lactone which is optionally substituted; wherein the bonds between C 3 :C 7 , C 4 :C 5 , and C 9 :C 10 may independently be double bonds or single bonds; or a derivative of said formula, wherein the derivative has at least one of the following: a lower acyl side chain at C 3 (free acid or ester or conjugate), a keto or hydroxy (free hydroxy or ester) moiety at the C 6 carbon, or an n-pentenyl or n-pentyl side chain at C 7 ; including salts, hydrates, solvates, polymorphs, optical isomers, enantiomers, diastereomers, and mixtures thereof.