Patent ID: 7608416

Claim:
A method of identifying an inhibitor of microsomal prostaglandin E synthase (mPGES-1) in a cell that does not increase risk of a cardiovascular event in an individual comprising said cell, the method comprising: a. measuring a first level of prostacyclin and a first level of prostaglandin E2 (PGE2) produced by a cell that expresses mPGES-1, b. administering a test compound to the cell, and c. measuring a second level of prostacyclin and a second level of PGE2 produced by the cell, wherein a test compound that reduces the second level of PGE2 compared to the first level of PGE2 and wherein the second level of prostacyclin is greater than the first level of prostacyclin is identified as an inhibitor of mPGES-1 that does not increase the risk of a cardiovascular event in an individual when administered to the individual.