Patent ID: 7112678

Claim:
A method of making a compound of Formula I: wherein: R 4 is alkyl, alkenyl, alkynyl, aryl or SiR 20 R 21 R 22 , wherein R 20 , R 21 and R 22 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl and aryl; R 1 is alkyl, aryl, alkenyl, alkynyl, or —SR″, where R″ is alkyl, aryl, alkenyl, alkynyl, or alkoxy; R 2 , R 5 , and R 6 are each independently selected from the group consisting of H, alkyl, aryl, alkenyl, alkynyl, alkoxy, and halo; R 7 is selected from the group consisting of H and alkyl; A is a 1 or 2 atom bridging species which forms part of a saturated or monounsaturated 5 or 6-membered ring including N 7 , C 8 , C 9 and B; B is; —C 10 HR 10a —or ═C 10 R 10a , wherein R 10a is selected from hydrogen, alkyl, hydroxyalkyl, aryl, aryloxyalkyl, fluoro, trifluoromethyl, cyano, cyanomethyl, —OR′, —NR′ 2 , or —SR′, wherein each R′ is independently hydrogen, alkyl, alkenyl, alkynyl or aryl; and R 9 and R 9a are each independently selected from hydrogen, alkyl, hydroxyalkyl, aryl, aryloxyalkyl, fluoro, trifluoromethyl, cyano, cyanomethyl, —OR′, —NR′ 2 , or —SR′, wherein each R′ is as defined above; comprising reacting an organometallic nucleophile R 4 Met, where R 4 is as given above and Met is a metal, with a compound of the formula: wherein A, B, R 2 , R 5 , R 6 , R 7 , R 9 , R 9a are as given above, and a compound of the formula R 1 COX 1 , wherein R 1 is as given above and X 1 is halo, to produce a compound of Formula I.