Patent ID: 7610153

Claim:
A method for titrating a multi-modality therapy regimen in an individual patient, comprising performing multiple times the steps of: i) providing p modalities to said individual patient in a plurality of dose combinations; ii) measuring one or more clinical endpoints in said individual patient; iii) assigning, using a computer, measurements made in said measuring step for each of said one or more clinical endpoints to a desirability function; iv) combining, using said computer, all desirability functions to obtain a composite desirability function for each of said plurality of dose combinations; v) associating, using said computer, each composite desirability function with a vertex of a geometric figure, wherein said geometric figure has vertices, and wherein each of said vertices represents one of said plurality of dose combinations; vi) outputting, using said computer, a next dose combination by applying an evolutionary operation direct search algorithm to said geometric figure; wherein performing steps i)-vi) multiple times constitutes titration of said multi-modality therapy regimen in said individual patient; and wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient.