Patent ID: 8367828

Claim:
A compound of formula I-1: wherein: R 1 is carboxyl or methyl ester thereof; R 2 is H; R 3 , R 4 , and R 5 are independently hydrogen, halo, optionally substituted lower alkyl, —CH 2 —CR 12 ═CR 13 R 14 , —CH 2 —C≡CR 15 , optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —OR 9 , —SR 9 , —NR 10 R 11 , —C(Z)NR 10 R 11 , —C(Z)R 20 , —S(O) 2 NR 10 R 11 , or —S(O) 2 R 21 ; R 6 and R 7 are each independently hydrogen or CH 3 ; n is 1; X is N or CR 8 , wherein R 8 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —OR 9 , —SR 9 , —NR 10 R 11 , —C(Z)NR 10 R 11 , —C(Z)R 20 , —S(O) 2 NR 10 R 11 , or —S(O 2 )R 21 ; Y is N; R 9 is optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl; R 10 and R 11 are independently hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl, or R 10 and R 11 combine to form a mono-carbocyclic or mono-heterocyclic 5- or 6-membered ring system; R 12 , R 13 , R 14 , and R 15 are independently optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl; R 20 is optionally substituted monofluoroalkyl, trifluoromethyl, optionally substituted difluoroalkyl, —CH 2 —CR 12 ═CR 13 R 14 , —CH 2 —C≡CR 15 , optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl; R 21 is optionally substituted lower alkoxy, —CH 2 —CR 12 ═CR 13 R 14 , —CH 2 —C≡CR 15 , optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl; and Z is O or S.