Patent ID: 8821899

Claim:
A composition comprising: a molecule-imprinted polymeric network comprising a polymer comprising acrylamide and ethylene glycol dimethacrylate imprinted with glucose molecule, one or more pores in the polymer wherein the one or more pores are micropores or nanopores that recognize a glucose molecule; one or more active agents in contact with the one or more pores and the polymer to form an active agent-load, molecule-imprinted polymeric network, wherein the one or more active agents comprise insulin, wherein subsequent contact with the glucose molecule creates internal stresses that rupture the polymeric network at the one or more pores, wherein the molecule-imprinted polymeric network is encapsulated with at least one coating layer containing an active agent layer; wherein rupture of the active agent-load, molecule-imprinted polymeric network is by at least one of: osmosis upon recognition and binding of the glucose molecule leading to rupture due to swelling; change of the solubility of the active agent-load, molecule-imprinted polymeric network leading to polymer dissolution; or local temperature changes leading to expansion of the active agent-load, molecule-imprinted polymeric network and combinations thereof.