Patent ID: 6933305

Claim:
An amide compound of the formula wherein R 1 is hydrogen, alkyl, cycloalkyl, halogen, hydroxyl, alkoxy, haloalkyl, hydroxyalkyl, aralkyl, acyl, alkoxycarbonyl, alkylcarbarnoyl, alkylsulfone, nitro, amino optionally having substituents selected from the group consisting of alkyl having 1 to 4 carbon atoms, acyl having 1 to 4 carbon atoms and benzoyl, cyano or phenyl; R 2 is hydrogen, alkyl, cycloalkyl, phenyl or aralkyl, or a group represented by the formula (II) in the formula (II), R 3 is hydrogen, alkyl or amino optionally having substituents selected from the group consisting of alkyl having 1 to 4 carbon atoms, acyl having 1 to 4 carbon atoms and benzoyl, and R 4 is hydrogen, alkyl, aralkyl, phenyl, nitro or cyano, or R 3 and R 4 may be bonded to form a heterocyclic ring selected from the group consisting of imidazol-2-yl, thiazol-2-yl, oxazol-2-yl, imidazolin-2-yl, 3,4,5,6-tetrahydropyridin-2-yl, 3,4,5,6-tetrahydropyrimidin-2-yl, 1,3-oxazolin-2-yl, 1,3-thiazolin-2-yl, benzoimidazol-2-yl, benzothiazoi-2-yl and benzooxazol-2-yl, which may have substituents selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, nitro, amino, phenyl and aralkyl; a is an integer of 1 to 4; X is S or SO 2 ; and Y is a group of the formula (III), (IV), (V) or (VI): in the formulas (III), (IV), (V) and (VI), R 5 and R 6 are the same or different and each is hydrogen, alkyl, cycloalkyl, phenyl, halogen, hydroxyl, alkoxy, alkoxyalkyl, nitro, amino optionally having substituents selected from the group consisting of alkyl having 1 to 4 carbon atoms, acyl having 1 to 4 carbon atoms and benzoyl or cyano, a geometrical isomer thereof or an optical isomer thereof or a pharmaceutically acceptable salt thereof.