Patent ID: 8017747

Claim:
A recombinant nucleic acid molecule comprising at least one expression control region for an inhibitor of apoptosis gene operatively linked to a polynucleotide comprising a coding region of an active apoptosis-inducing protein (AIP), wherein the expression control region is the human survivin promoter comprising a sequence selected from the group consisting of SEQ ID NO:1 and nucleotides 68-268 of SEQ ID NO:1, and wherein the coding region comprises a sequence encoding a protein selected from the group consisting of Granzyme B (SEQ ID NO: 4), Granzyme B (SEQ ID NO: 6), Granzyme H (SEQ ID NO: 38), Granzyme C (SEQ ID NO: 26), Granzyme F (SEQ ID NO: 31), and variants of the coding region that are at least 90% identical to the coding region and encode a protein retaining an apoptosis-inducing function.