Patent ID: 8404681

Claim:
A compound having a formula or a pharmaceutically acceptable salt thereof, wherein m is an integer 0 through 3; X is O, S(O) 0-2 , or NR a ; Z, independently, is CR b or N; R 1 , independently, is selected from the group consisting of halo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, N(R d ) 2 , OR d , carboxy, wherein the carboxy is not carboxyl, nitro, OC 1-3 alkyleneN(R d ) 2 , N(R d )—C 1-3 alkyleneN(R d ) 2 , OC 1-3 alkyleneC(═O)OR d , O(C 1-3 alkylene) OP(═O)(OR d ) 2 , O(C 1-3 alkylene)OP(═O)(ONa) 2 , OP(═O)—(OR d ) 2 , OP(═O)(ONa) 2 , cyano, aldehyde, carboxamide, thiocarboxamide, acyl, mercapto, sulfonyl, trifluoromethyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or two R 1 groups are taken together with the atoms to which each is attached to form a 5-, 6-, or 7-membered ring, wherein 1 or 2 carbon atoms of R 1 optionally is a heteroatom selected from the group consisting of O, N, and S, said ring optionally substituted with one or more ═O, ═S, ═NH, OR d , N(R d ) 2 , carboxyl, carboxy, alkyl, aryl, substituted aryl, heteroaryl, or substituted hetercaryl, said heteroatom optionally substituted with a group selected from the group consisting of aryl, substituted aryl, alkyl, substituted alkyl, and acyl; R a is selected from the group consisting of hydro, C 1-4 alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C 1-3 alkylenearyl, C 1-3 alkyleneheteroaryl, C 1-3 alkyleneheterocycloalkyl, C 1-4 alkylene-N(R d ) 2 , C 1-4 alkyleneOR d , C 1-4 alkyleneC(═O)OR d , C(═O)R d , C(═O)N(R d ) 2 , C(═O)OR d , C(═O)SR d , C(═S)N(R d ) 2 , SO 2 R d , SO 2 N(R d ) 2 , C(═O)NR d C 1-4 alkyleneOR d , C(═O)NR d C 1-4 alkyleneheterocycloalkyl, C(═O)C 1-4 alkylenearyl, C(═O)C 1-4 alkyleneheteroaryl, C 1-4 alkyleneC(═O)C 1-4 alkylenearyl, C 1-4 alkyleneC(═O)C 1-4 alkyleneheteroaryl, C 1-4 alkylene-C(═O) heterocycloalkyl, C 1-4 alkyleneNR d C(═O)R d , C 1-4 alkyleneOC 1-4 alkyleneOR d , C 1-4 alkyleneOC 1-4 alkyleneC(═O)OR d , and C 1-4 alkyleneC(═O)N(R d ) 2 ; R b , independently, is selected from the group consisting of hydro, alkyl, halo, aldehyde, OR d , O(C 1-3 alkylene)OP(═O)(OR d ) 2 , O(C 1-3 alkylene)OP(═O)(ONa) 2 , OP(═O)(OR d ) 2 , OP(═O)(ONa) 2 , nitro, N(R d ) 2 , carboxyl, carboxy, sulfonamido, sulfamyl, and sulfo; and R d , independently, is selected from the group consisting of hydro, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, C 1-3 alkylenearyl, substituted aryl, heteroaryl, and substituted heteroaryl.