Patent ID: 7977354

Claim:
A compound of formula G or a pharmaceutical salt or a stereoisomer of G; wherein: the dotted circle line represents one double bond between CR 5 -CR 6 , and another double bond between either CR 2 -CR 3 or CR 3 -CR 4 ; and a) except as provided in c) below, R 1 , R 2 , R 3 , and R 4 , which may be identical or different, are each selected from the group consisting of hydrogen, OH, (C 1 -C 8 ) alkyl, aryl, heteroaryl, (C 1 -C 8 ) alkylaryl, aryl (C 1 -C 8 ) alkyl, alkoxy, hydroxy (C 1 -C 8 ) alkyl, alkoxy (C 1 -C 8 ) alkyl, phenyl, (CH 2 ) n —COOH, Z and Z 1 , and b) R 5 and R 6 taken together with the carbon atoms to which R 5 and R 6 are attached form a ring selected from the group consisting of a 6-membered aromatic ring and a 5- or 6-membered heterocyclic ring, the ring being optionally substituted by one or more group, identical or different, each selected from the group consisting of OH, (C 1 -C 8 ) alkyl, aryl, heteroaryl, (C 1 -C 8 ) alkylaryl, aryl (C 1 -C 8 ) alkyl, alkoxy, hydroxy (C 1 -C 8 ) alkyl, alkoxy (C 1 -C 8 ) alkyl, phenyl, (CH 2 ) n —COOH, Z and, Z 1 ; and c) at least one group among R 2 and R 3 is an electron withdrawing group selected from the group consisting of COOR, COSR, CONRR′, CN, COR, CF 3 , SOR, SO 2 R, SONRR′, SO 2 NRR′, NO 2 , halogen and heteroaryl, wherein R, and R′ are each a group selected from the group consisting of H, alkyl, cycloalkyl, arylalkyl, heteroarylalkyl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, alkylaminoalkyl, aminoalkyl, heteroaryloxyalkyl, halogenoalkyl, thioalkyl, thioalkoxyalkyl, aryl, alkylaryl, hydroxyaryl, alkoxyaryl, aryloxyaryl, aminoaryl, alkylaminoaryl, halogenoaryl, heteroaryl, alkylheteroaryl, alkoxyheteroaryl, aminoheteroaryl, alkylaminoheteroaryl and halogenoheteroaryl, or R and R′ taken together with the nitrogen atom to which they are attached form an heterocyclic ring of at least 3 members optionally substituted by one or more groups being as defined for R 2 , or R and R′ taken together with the nitrogen atom to which they are attached form a fused polyheterocyclic system, optionally tetrahydroisoquinoline, indoline or isoindoline, optionally substituted by one or more group being as defined for R 2 ; and wherein Z is a group defined by formula -(L) m -Z 1 , wherein L is selected from the group consisting of (C 1 -C 8 ) alkyl, aryl, heteroaryl, phenyl, (C 1 -C 8 ) alkylaryl and aryl(C 1 -C 8 ) alkyl; Z 1 is defined by formula wherein X and Y are each selected from the group consisting of O and S; wherein R 7 and R 8 , which may be identical or different, are each selected from the group consisting of hydrogen, (C 1 -C 8 ) alkyl, aryl, heteroaryl, (C 1 -C 8 ) alkylaryl, phenyl, cyclopropyl and(CH 2 ) n —COOH; and wherein n and m are each an integer ≧1, optionally m is comprised between 1 and 4 and n is comprised between 1 and 6; and provided that at least one of R 1 , R 2 , R 3 and R 4 is Z or Z 1 and that R 1 is not H or Z 1 .