Patent ID: 8835510

Claim:
A method of treating a subject with a disease or tissue injury mediated by cellular oxidative stress, wherein the disease or tissue injury is atherosclerosis, diabetes, Alzheimer's disease, stroke or traumatic spinal cord injury, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I) wherein R 1 and R 2 are independently H, alkyl, alkoxy alkyl, acyloxy alkyl, aryl, aryloxy, acyloxy aryl, heteroaryl, heteroaryloxy, or acyloxy heteroaryl; X is COR 3 , CO 2 R 3 , NO 2 , CN, CON(R 3 ) 2 , or SO 2 R 3 ; R 3 is H, alkyl, alkoxy alkyl, acyloxy alkyl, aryl, aryloxy, acyloxy aryl, heteroaryl, heteroaryloxy, acyloxy heteroaryl, or trifluoromethyl; and/or R 2 forms a ring together with either R 1 or R 3 , or R 2 forms rings with both R 1 and R 3 ; wherein any ring formed between R 2 with R 1 and/or R 3 optionally and independently contains one or more O, S, N or substituted N, where substitution at N is an alkyl or acyl group; wherein any alkyl can independently be branched or unbranched; wherein any aryl or heteroaryl can independently be optionally substituted with —CH3, —NH2, —OH, ═O, halogen, alkyl, alkoxy, acyloxy, aryl and/or acyloxyaryl; or a tautomer thereof; or a geometric or optical isomer thereof; or racemate thereof; or a pharmaceutically acceptable salt thereof.