Patent ID: 7977312

Claim:
An isolated polypeptide that retains the biological activity of SEQ ID NO: 2 in regulating bone mineral content, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of: (a) amino acid sequences having at least 85% sequence identity to SEQ ID NO: 2; (b) amino acid sequences encoded by a polynucleotide sequence having at least 85% sequence identity to SEQ ID NO: 1; (c) amino acids 25-213 of SEQ ID NO: 2; (d) amino acid sequences having at least 85% sequence identity to amino acids 25-213 of SEQ ID NO: 2; (e) amino acid sequences encoded by a polynucleotide sequence having at least 85% sequence identity to nucleotides 119-686 of SEQ ID NO: 1; and (f) amino acid sequences encoded by a polynucleotide sequence that specifically hybridizes to the full complement of SEQ ID NO: 1, under conditions of high stringency comprising hybridization in 5×SSPE, 5×Denhardt's solution and 0.5% SDS overnight at 55 to 60° C.; followed by a post hybridization wash at 0.5×SSC at 55-60° C.