Patent ID: 7015323

Claim:
A compound of formula I: wherein q is 0 or 1; T is O, CHR 6 , NR 6 , S, SO, SO 2 , —NR 6 C(O)—, —C(O)NR 6 —; R a and R b are each independently hydrogen, alkyl, alkoxy, a carbocycle, a heterocycle, optionally substituted with halogen, hydroxy, amino, carboxyl, nitro, cyano, a carbocycle or a heterocycle; and one to three carbon atoms of said alkyl and alkoxy groups are optionally replaced with carbonyl, NR 6 , O, S, SO or SO 2 ; or R a and R b together with the nitrogen to which they are attached may form a heterocycle or heteroaryl group substituted with 0–4 R 1 substituents; R c is H, alkyl, optionally substituted with hydroxy, halogen, alkoxy, amino, a carbocycle or a heterocycle; and one to three carbon atoms of said alkyl are optionally replaced with carbonyl, NR 6 , O, S, SO or SO 2 ; L is —C(S)—O— or —C(O)—S—; Y is CH 2 or absent when p is 0; Z is H or lower alkyl, or when p is 1 then Z and Y together with the atoms from which they depend form a 5 member saturated or partially unsaturated 5 or 6 member heterocycle; R 1 in each instance is independently selected from the group consisting of hydroxy, amino, amidine, guanidine, carboxyl, nitro, cyano, thiol, alkyl, alkoxy a carbocycle and a heterocycle wherein said alkyl and alkoxy groups are optionally substituted with one or more hydroxyl, halogen, amino, amidine, guanidine, carboxyl, nitro, cyano, carbocycle or heterocycle; and one to three carbon atoms of said alkyl and alkoxy groups are optionally replaced with carbonyl, NR 6 , O, S, SO or SO 2 ; and said carbocycle and heterocycle group is optionally substituted with one or more hydroxyl, halogen, amino, amidine, guanidine carboxyl, nitro, cyano, alkyl, alkoxy or haloalkyl; or two R 1 substituents together with the atoms from which they depend form a fused or bridged heterocycle optionally substituted with one or more hydroxyl, halogen, amino, amidine, guanidine carboxyl, nitro, cyano, alky, alkoxy or haloalkyl; R 2 and R 3 in each instance are independently selected from the group consisting of hydroxy, amino, amidine, guanidine, carboxyl, nitro, cyano, thiol, alkyl, alkoxy, a carbocycle and a heterocycle wherein said alkyl and alkoxy groups are optionally substituted with one or more hydroxyl, halogen, amino, amidine, guanidine, carboxyl, nitro, cyano, alkoxy, carbocycle or heterocycle; and one to three carbon atoms of said alkyl group is optionally replaced with carbonyl, NR 6 , O, S, SO or SO 2 ; and said carbocycle and heterocycle group is optionally substituted with one or more hydroxyl, halogen, amino, amidine, guanidine, carboxyl, nitro, cyano, alkyl, alkoxy or haloalkyl; R 4 is H, alkyl, a carbocycle or heterocycle wherein said alkyl is optionally substituted with a carbocycle or heterocycle and said alkyl, carbocycle and heterocycle are optionally substituted with lower alkyl, halogen, hydroxyl, alkoxy, haloalkyl or amino; R 6 in each instance is independently H, alkyl or a carbocycle; m, n, and o are each independently 0–4; p is 0 or 1; and salts and solvates thereof.