Patent ID: 7109231

Claim:
A tricyclic compound represented by the formula (I), or a pharmaceutically acceptable salt, solvate or prodrug thereof; wherein; R 1 is the group —(La)-(acidic group) wherein —(L a )—, is an acid linker having an acid linker length of 1 to 8; R 2 , R 3 , and R 4 are each independently selected from non-interfering substituents including hydrogen: R 5 is the group (C 1 –C 20 )alkyl, (C 1 –C 20 )haloalkyl, (C 2 –C 20 )alkenyl, (C 2 –C 20 )alkynyl, (C 1 –C 10 )alkylaryl, (C 1 –C 5 )alkylcyclohexyl, (C 1 –C 5 )alkylcyclopentyl, (C 1 –C 5 )alkylcycloheptyl, phenyl, benzyl, methylnaphthyl, (C 1 –C 5 )alkylheterocyclic, carbocyclic radical, or heterocyclic radical, or aryl; R 6 , R 7 , R 8 , and R 9 , are each independently selected from hydrogen, or a group consisting of 1 to 10 non-hydrogen atoms plus any required hydrogen atoms; R 10 is selected from an amide or thioamide group represented by the formula, wherein X is oxygen or sulfur, R a and R a′ is independently selected from hydrogen, (C 1 –C 8 )alkyl, or aryl; R a″ is hydrogen, NH 2 , (C 1 –C 8 )alkyl, aryl, (C 1 –C 8 )alkylaryl, or arylalkyl; and n is 0, 1, or 2.