Patent ID: 8478535

Claim:
A system that facilitates determining an epitome that provides a basis for a vaccine cocktail, comprising: a processing unit; a system memory coupled to the processing unit; an input component that receives a plurality of overlapping patches x S corresponding to a set of subsequences from one or more pathogen sequences in a population; and a modeling engine that employs one or more machine learning algorithms to determine an epitome based on the plurality of overlapping patches x S , the epitome providing the basis for the vaccine cocktail, wherein the one or more machine learning algorithms comprises an expectation-maximization (EM) algorithm that includes an initial random guess for the epitome and iteratively reduces a free energy of the epitome converging to a local minimum of free energy, wherein the free energy combines T cell binding energy and HLA binding via a variational mapping distribution of respective ones of the plurality of overlapping patches x S to the epitome.