Patent ID: 8455376

Claim:
An adhesive preparation, comprising: a stretchable support comprising a crimped interlock woven fabric; and an adhesive layer laminated on at least one side of the support, the adhesive layer consisting of methyl salicylate present of an amount of from 10% to 15% by mass with respect to the total mass of the adhesive layer, I-menthol present in an amount of from 3.0 to 4.5% by mass with respect to the total mass of the adhesive layer, a thermoplastic elastomer of both polyisobutylene and styrene-isoprene-styrene block copolymer present in an amount of from 35% to 40% by mass with respect to the total mass of the adhesive layer, liquid paraffin present in an amount of from 20 to 35% by mass with respect to the total mass of the adhesive layer, and alicyclic saturated hydrocarbon resin present in an amount of from 17% by mass to 20.5% by mass with respect to the total mass of the adhesive layer, the whole adhesive preparation having a moisture permeability of 1 to 350 g/m 2 ·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the adhesive preparation being configured such that the methyl salicylate yields a plasma AUC 0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate yields a plasma AUC 0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer is 50 to 300 g/m 2 and a contact area is 280 cm 2 .