Patent ID: 7378056

Claim:
A circuit for detecting biomolecules in vivo, the circuit comprising an optical radiation source configured for in vivo use that emits first optical radiation; an optical radiation detector configured for in vivo use that detects second optical radiation emitted by excited labeled binding molecules; and a processor circuit, coupled to the optical radiation source and the optical radiation detector, wherein the processor circuit is configured to release fluorescently labeled antibodies selected to bind with predetermined Tumor Specific Antigens (TSAs), the processor circuit is further configured to activate the in vivo optical radiation source after a predetermined first time interval after release of the fluorescently labeled antibodies, the predetermined first time interval selected to allow a first portion of the fluorescently labeled antibodies to bind with local available TSAs and a second portion of the fluorescently labeled antibodies to become remote from the circuit so that the first optical radiation excites the first portion of the fluorescently labeled antibodies bound with the local available TSAs and does not excite the second portion of the fluorescently labeled antibodies that become remote, the processor circuit is further configured to sense a voltage generated by the in vivo optical radiation detector after a second predetermined time interval, the second predetermined time interval being after emission of the first optical radiation has ceased.