Patent ID: 8293762

Claim:
A compound represented by formula (I) wherein R 1 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )polyfluorinated alkyl, heterocyclyl, aryl, heteroaryl, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkyl, heterocyclyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkyl, heteroaryl-(C 1 -C 6 )alkyl, (C 1 -C 8 )hydroxyalkyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, aryloxy-(C 1 -C 8 )alkyl, heteroaryloxy-(C 1 -C 8 )alkyl, (C 1 -C 8 )aminoalkyl, (C 1 -C 8 )alkylamino-(C 1 -C 8 )alkyl, (C 1 -C 8 )dialkylamino-(C 1 -C 8 )alkyl, carbamoyl-(C 1 -C 8 )alkyl, and alkoxycarbonyl, wherein each of said aryl, heteroaryl, heterocyclyl, aryloxy, or heteroaryloxy moieties can be unsubstituted or substituted by one or more substituents, each substituent being independently selected from the group consisting of alkyl, aryl, —OCF 3 , —OC(O)alkyl, —OC(O)aryl, —CF 3 , heteroaryl, aralkyl, alkylaryl, heteroaralkyl, alkylheteroaryl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aryl, halo, haloalkyl, haloalkoxy, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, heterocyclyl, heterocyclenyl, —NH(alkyl), —NH(cycloalkyl), and —N(alkyl) 2 ; R 2 , R 3 , R 4 and R 5 are each independently selected from the group consisting of hydrogen atom, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, heterocyclyl, aryl, cycloalkyl-alkyl, heterocyclyl-(C 1 -C 6 )alkyl, aryl-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )polyfluorinated alkyl, (C 1 -C 8 )hydroxyalkyl, (C 1 -C 8 )alkoxy-(C 1 -C 8 )alkyl, aryloxy(C 1 -C 8 )alkyl, heteroaryloxy(C 1 -C 8 )alkyl, (C 1 -C 8 )aminoalkyl, (C 1 -C 8 )alkylamino(C 1 -C 8 )alkyl, and (C 1 -C 8 )dialkylamino-(C 1 -C 8 )alkyl, or R 2 , R 3 , R 4 and R 5 , taken together, form a (C 3 -C 6 )cycloalkyl group; X is NH or CH 2 , with the provisos that, when X is NH and R 1 is hydrogen atom, at least one of R 2 , R 3 , R 4 and R 5 is not a hydrogen atom and 7H-pyrido[4,3-a]carbazol-7-one, 8,9,10,11-tetrahydro-11-(phenylmethyl) is excluded; or a pharmaceutically acceptable salt thereof.