Patent ID: 7459270

Claim:
An isolated Modified Vaccinia Ankara (MVA) virus characterized by having the capability of reproductive replication in vitro in chicken embryo fibroblasts (CEF), but no capability of reproductive replication in vitro in the human keratinocyte cell line HaCaT and the human cervix adenocarcinoma cell line HeLa: wherein the isolated MVA virus is generated by: (a) introducing a Modified Vaccinia Ankara strain into non-human cells in which the virus is able to reproductively replicate; (b) isolating an MVA virus from the infected cells; and (c) determining that said isolated MVA virus has the capability of reproductive replication in vitro in chicken embryo fibroblasts (CEF), but no capability of reproductive replication in vitro in the human keratinocyte cell line HaCaT and the human cervix adenocarcinoma cell line HeLa.