Patent ID: 8333983

Claim:
A drug delivery system comprising at least one compartment comprising (i) a drug-loaded ethylene-vinylacetate copolymer core, (ii) a drug-loaded ethylene-vinylacetate copolymer intermediate layer and (iii) a non-medicated ethylene-vinylacetate copolymer skin covering the intermediate layer, wherein said intermediate layer is loaded with (a) crystals of a first steroid or anti-microbial agent and with (b) a second steroid or anti-microbial agent in dissolved form and wherein said core is loaded with said second steroid or anti-microbial agent compound in dissolved form; the compartment having a radius R 1 , a radius R 2 defined by the radius of said core together with said intermediate layer, and a radius R 3 defined by the radius of said core; wherein the ratio of R 1 /R 2 is between 1.0500-1.2000 and the ratio of R 2 /R 3 is between 1.0200-1.5000.