Patent ID: 6858649

Claim:
A method for potentiating a serotonin response within a cell having a human serotonin receptor of the subtype 5-HT 1A , the method comprising the following step: contacting the cell having the human serotonin receptor subtype 5-HT 1A with a quantity of a serotonergic agent possessing 5-HT 1A agonist activity sufficient for potentiating the serotonin response within said cell, said serotonergic agent being selected from compounds represented by the structure: wherein: X is a diradical selected from the group represented by the following structures: wherein Z is a radical selected from the group consisting of: —CH 2 — and —O—; Y is a diradical selected from the group consisting of: —CH 2 —, —CH(CH 3 )—, —C(CH 3 ) 2 —, —O—, —NH—, —CH(SH)—, —CH(SAc)—, —CH(OH)—, —CHCl—, —C(═O)—, —C(═O)CH 2 —, —CH 2 NHC(═O)—, and —CH 2 N(CH 3 )C(═O)—; R 1 is a radical selected from the group consisting of: hydrogen, —NH 2 , OH, MeNH—, Me 2 N—, EtNH—, Et 2 N—, CH 2 ═CHCH 2 NH—, n-propyl-NH—, i-propyl-NH—, cyclopropyl-NH—, i-propyl-NMe-, butyl-NH—, pyrrolidine-, phenyl-NH—, phenyl(CH 2 ) 3 NH—, HONH—, MeONMe-, NH 2 NH—, CH 3 O—, CH 3 CH 2 O—, CH 3 (CH 2 ) 2 O—, Me 2 CHCH 2 O—, H—, CF 3 —, BrCH 2 —, ClCH 2 —, N 2 CH—, HOCH 2 CH 2 NH—, (HOCH 2 CH 2 ) 2 N—, HOCH 2 CH 2 CH 2 NH—, HOCH 2 CH(OAc)CH 2 O—, and HO 2 CCH 2 NH—; R 2 is a radical selected from the group consisting of: —CH 3 ,—CH 2 OCH 3 , and —CO 2 H; n is an integer from 0 to 15; m is an integer from 0 to 15 with the requirement that the sum of n+m is an integer from 11 to 15; with the following provisos: if Y is —CH 2 — and R 2 is —CH 3 , then R 1 can not be —NH 2 .