Patent ID: 7638535

Claim:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof, wherein —R 1 —R 2 — is a bivalent radical of formula —O—CH 2 —CH 2 —O— (a-3), —O—CH 2 —CH 2 —CH 2 —O— (a-5), wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C 1-6 alkyl or hydroxy, R 3 is hydrogen, halo, C 1-4 alkyl; R 4 is C 1-6 alkyl; C 1-6 alkyl substituted with cyano, or C 1-6 alkyloxy; C 1-6 alkyloxy; cyano; amino or mono or di(C 1-6 alkyl)amino; R 5 is hydrogen or C 1-6 alkyl, and the —OR 5 radical is situated at the 3- or 4-position of the piperidine moiety; L is hydrogen, or L is a radical of formula -Alk-R 6 (b-1), -Alk-X—R 7 (b-2), -Alk-Y—C(═O)—R 9 (b-3), or -Alk-Z-C(═O)—NR 11 R 12 (b-4), wherein each Alk is C 1-12 alkanediyl; and R 6 is hydrogen; hydroxy; cyano; C 3-6 cycloalkyl; C 1-6 alkylsulfonylamino; aryl or Het; R 7 is C 1-6 alkyl; C 1-6 alkyl substituted with hydroxy; C 3-6 cycloalkyl; aryl or Het; X is O, S, SO 2 or NR 8 ; said R 8 being hydrogen or C 1-6 alkyl; R 9 is C 1-6 alkyl or hydroxy; Y is a direct bond; Z is a direct bond or O; R 11 and R 12 each independently are hydrogen, or C 1-6 alkyl, or R 11 and R 12 combined with the nitrogen atom bearing R 11 and R 12 may form a pyrrolidinyl, or piperazinyl substituted with C 1-6 alkyl; aryl represents unsubstituted phenyl or phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, and aminosulfonyl; and Het is tetrahydrofuranyl; tetrahydrofuranyl substituted with C 1-6 alkyl; dioxolanyl; dioxolanyl substituted with C 1-6 alkyl; pyridinyl; pyridinyl substituted with one or two substituents each independently selected from halo, hydroxy, C 1-6 alkyl; pyrimidinyl; pyrimidinyl substituted with one or two substituents each independently selected from halo, hydroxy, or C 1-6 alkyl; pyridazinyl; pyridazinyl substituted with one or two substituents each independently selected from hydroxy, C 1-6 alkyloxy, C 1-6 alkyl or halo; pyrazinyl; pyrazinyl substituted with one or two substituents each independently selected from hydroxy, C 1-6 alkyloxy, C 1-6 alkyl or halo.