Patent ID: 8178563

Claim:
A compound of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, in which: R 1 is selected from cyano, C 1-6 alkyl, halosubstituted-C 1-6 alkyl, C 1-6 alkoxy, halosubstituted-C 1-6 alkoxy, dimethyl-amino, C 1-6 alkyl-sulfanyl and C 3-8 heterocycloalkyl optionally substituted with up to two C 1-6 alkyl radicals; R 2 and R 5 are independently selected from hydrogen, cyano, halo, C 1-6 alkyl, halosubstituted-C 1-6 alkyl, C 1-6 alkoxy, halosubstituted-C 1-6 alkoxy and dimethylamino; R 3 and R 4 are independently selected from hydrogen, halo, cyano, C 1-6 alkyl, halosubstituted-C 1-6 alkyl, C 1-6 alkoxy and halosubstituted-C 1-6 alkoxy; R 6 and R 7 are independently selected from hydrogen, fluoro, chloro, bromo, C 1-6 alkyl, halosubstituted-C 1-6 alkyl, C 1-6 alkoxy and halosubstituted-C 1-6 alkoxy; with the proviso that R 6 and R 7 are not both hydrogen; R 8 is selected from hydrogen, halo, C 1-6 alkyl, halosubstituted-C 1-6 alkyl, C 1-6 alkoxy and halosubstituted-C 1-6 alkoxy; R 9 is selected from —S(O) 2 R 11 , —OR 11 , —C(O)R 11 , —NR 12a R 12b and —R 11 ; wherein R 11 is selected from thiomorpholino, sulfonomorpholino, morpholino, cyclohexyl, phenyl, azepan-1-yl, 2-oxopiperazin-1-yl, 1,4-oxazepan-4-yl, piperidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-yl, piperazinyl, pyrrolidinyl and 1,4-diazepan-1-yl; R 12a and R 12b are independently selected from isobutyl, hydroxy-ethyl, wherein said thiomorpholino, sulfonomorpholino, morpholino, cyclohexyl, phenyl, azepan-1-yl, 2-oxopiperazin-1-yl, 1,4-oxazepan-4-yl, piperidin- 1 -yl, tetrahydro-2H-pyran-4-yl, piperidin-3-yl, piperazinyl, pyrrolidinyl or 1,4-diazepan-1-yl of R 9 can be optionally substituted with 1 to 3 radicals independently selected from methyl, ethyl, methoxy, benzyl, thienyl-methyl, pyridinyl-methyl, benzo[d][1,3]dioxo1-6-yl and 2,3-dihydrobenzo[b][1,4]dioxin-7-yl; wherein said benzyl substituent of R 9 is optionally substituted with 1 to 3 radicals independently selected from methoxy, ethoxy, methyl-piperazinyl, methyl, trifluoromethoxy, chloro, fluoro and trifluoromethyl.