Patent ID: 8822551

Claim:
A hyaluronic acid epoxide derivative film, wherein a polymer containing a hydroxyl (—OH) terminal group is physically bonded to a crosslinked hyaluronic acid structure; wherein the hyaluronic acid epoxide derivative film is comprised of 50-90 wt % of hyaluronic acid and 10-50 wt % of the polymer containing the hydroxyl (—OH) terminal group; wherein the polymer containing the hydroxyl (—OH) terminal group is one or more selected from the group consisting of polyethylene oxide, polyvinyl alcohol, polypropylene oxide, a polyethylene oxide-polypropylene oxide copolymer, a polyethylene oxide-polylactic acid copolymer, a polyethylene oxide-polylactic glycolic acid copolymer, a polyethylene oxide-polycaprolactone copolymer, polybutylene oxide, polyoxyethylene alkyl ethers, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene stearates; wherein the crosslinked hyaluronic acid structure is formed by reacting 100 parts by weight of hyaluronic acid, hyaluronic acid salt or a mixture thereof, and 5-25 parts by weight of an epoxide crosslinker under basic conditions; and wherein the derivative film has a crosslinking density of 1-100 mole %.