Patent ID: 7625891

Claim:
A compound according to formula I wherein: R 1 is: (a) C 3-6 cycloalkyl, wherein said cycloalkyl is optionally substituted with one to three groups independently selected from the group consisting of hydroxy, C 1-3 alkyl, oxo, halogen, C 1-6 alkoxy-oximino, and C 1-6 alkoxy-C 1-6 alkyloxy; (b) C 3-6 cycloalkyl-C 1-3 alkyl wherein said cycloalkyl is optionally substituted with one to three groups independently selected from the group consisting of hydroxy, C 1-3 alkyl, oxo, halogen, C 1-6 alkoxy-oximino and C 1-6 alkoxy-C 1-6 alkyloxy with the proviso that said C 3-6 cycloalkyl-C 1-3 alkyl is not 4,4-difluorocyclohexyl-methyl or 1-hydroxyl-cyclohexyl-methyl wherein R 6 is hydrogen or halogen; wherein m is 0 or 2; (g) heteroaryl, heteroaryl C 1-3 alkyl, phenyl C 1-3 alkyl wherein said heteroaryl is pyridine, pyrimidine, pyrazine or pyridazine and said heteroaryl or said phenyl is independently substituted with 1 to 3 substituents independently selected from C 1-6 alkyl, halogen, C 1-6 alkoxy, cyano or nitro; (h) C 1-6 haloalkyl; R 2 is C 1-6 alkyl; R 3 is hydrogen or C 1-3 alkyl; R 4 is selected from the group consisting of (a)-(k) and (l): (a) 4,6-dimethyl-pyrimidin-5-yl; (b) 4,6-dimethyl-2-trifluoromethyl-pyrimidin-5-yl; (c) 2,4-dimethyl-pyridin-3-yl; (d) 2,4-dimethyl-1-oxy-pyridin-3-yl (e) 6-cyano-2,4-dimethyl-pyridin-3-yl; (f) 2,4-dimethyl-6-oxo-6H-pyran-3-yl (g) 2,4-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl; (h) 1,2,4-trimethyl-6-oxo-1,6-dihydro-pyridin-3-yl; (i) 3,5-dimethyl-1-oxy-1H-pyrazol-4-yl; (j) 5-cyano-2,4-dimethyl-1H-pyrrol-3-yl; (k) 3-methyl-5-trifluoromethyl-isoxazol-4-yl; and, (l) 3,5-dimethyl-1-hydroxy-pyrazol-4-yl; R 5 is C 1-6 acyl, C 1-6 alkoxycarbonyl, C 1-6 alkyl SO 2 , C 1-6 haloalkyl, C 3-6 cycloalkyl, oxetanyl, tetrahydrofuranyl or tetrahydropyranyl; n is 0 to 3; and, p is 1 or 3; or, a pharmaceutically acceptable acid addition salt thereof.