Patent ID: 8143408

Claim:
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: formula I corresponds to: X is O or CH 2 ; R 1 is pyridinyl, pyrazolyl, isoxazolyl, pyrimidinyl, pyridazinyl, imidazopyridinyl, or pyrazinyl, wherein: any such group may be independently mono-, di-, or tri-substituted with R 11 , R 12 , and/or R 13 ; R 11 , R 12 , and R 13 are independently selected from halogen, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl, C 1-6 hydroxyalkyl, C 3-6 cycloalkyloxy, C 3-6 cycloalkylC 1-6 alkoxy, cyano, hydroxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 haloalkoxyC 1-6 alkoxy, C 1-6 haloalkoxyC 1-6 alkyl, C 1-6 alkylsulfonic acid-, C 1-6 haloalkylsulfonic acid-, C 3-6 cycloalkylsulfonic acid-, C 3-6 halocycloalkylsulfonic acid-, C 3-6 cycloalkylC 1-6 alkylsulfonic acid-, C 3-6 halocycloalkylC 1-6 alkylsulfonic acid-, C 1-6 alkylsulfonyl-, C 1 -6 haloalkylsulfonyl-, C 3-6 cycloalkylsulfonyl-, C 3-6 halocycloalkylsulfonyl-, C 3-6 cycloalkylC 1-6 alkylsulfonyl, C 3-6 halocycloalkylC 1-6 alkyl-sulfonyl, phenyl, phenylC 1-6 alkyl-, phenoxy, C 1-6 alkylphenyl-, C 1-6 alkoxyphenyl-, C 1-6 alkylamine, C 1-6 haloalkylamine, —C(O)NHC 1-6 alkyl, —C(O)N(C 1-6 alkyl) 2 , and —C(O)NH 2 ; R 2 is pyrazinyl, phenyl, pyridinyl, quinoxalinyl, triazolyl, pyridonyl, naphthyridinyl, pyrimidinyl, or quinolinyl, wherein: any such group may be independently mono-, di-, or tri-substituted with R 14 , R 15 , and/or R 16 ; R 14 , R 15 , and R 16 are independently selected from halogen, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 3-6 alkynyloxy, C 3-6 cycloalkyl, C 3-6 heterocycloalkyl, C 3-6 cycloalkyloxy, C 3-6 heterocycloalkyloxy, C 3-6 cycloalkylC 1-6 alkoxy, C 1-6 alkyl-C 3-6 cycloalkylC 1-6 alkoxy, C 3-6 heterocycloalkylC 1-6 alkoxy, C 1-6 alkyl-C 3-6 heterocycloalkylC 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 haloalkoxyC 1-6 alkoxy, C 1-6 haloalkoxyC 1-6 alkyl, cyano, hydroxyl, NR 4 R 5 , C 1-6 alkylsulfonic acid-, C 1-6 haloalkylsulfonic acid-, C 3-6 cycloalkylsulfonic acid-, C 3-6 halocycloalkylsulfonic acid-, C 3-6 cycloalkylC 1-6 alkylsulfonic acid-, C 3-6 halocycloalkylC 1-6 alkylsulfonic acid-, C 1-6 alkylsulfonyl-, C 1-6 haloalkylsulfonyl-, C 3-6 cycloalkylsulfonyl-, C 3-6 halocycloalkylsulfonyl-, C 3-6 cycloalkyl-C 1-6 alkyl-sulfonyl, C 3-6 halocycloalkyl-C 1-6 alkyl-sulfonyl, phenyl, phenylC 1-6 alkyl-, phenoxy, C 1-6 alkylphenyl-, C 1-6 alkoxyphenyl-, —C(O) NR 4 R 5 , —C(O)C 3-6 cycloalkyl, —C(O)C 3-6 heterocycloalkyl, —C(O)C 3-6 cycloalkylC 1-6 alkoxy, —C(O)C 3-6 heterocycloalkylC 1-6 alkoxy, —C(O)C 3-6 cycloalkylC 1-6 alkyl, and —C(O)C 3-6 heterocycloalkylC 1-6 alkyl; and R 4 and R 5 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxyC 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 halocycloalkyl, C 3-6 heterocycloalkyl, and C 3-6 heterocycloalkylC 1-6 alkyl.