Patent ID: 8722331

Claim:
A method for selecting a treatment for non-small cell carcinoma (NSCLC), the method comprising the steps of: a) providing a sample of NSCLC cells from an individual; b) determining the levels of mRNA of each of ERCC2, XPC, ABCC5, GTF2H2, XPA and XRCC1 in the sample of NSCLC cells, wherein the levels are determined by quantitative RT-PCR; c) calculating ratios of ABCC5/GTF2H2, XPA/XPC, XRCC1/XPC, ERCC2/XPC and ERCC2/GTF2H2 using the levels determined in step b); d) comparing the ratios of step c) to that of ratios of ABCC5/GTF2H2, XPA/XPC, XRCC1/XPC, ERCC2/XPC and ERCC2/GTF2H2 in control NSCLC cells that are cisplatin-resistant, wherein comparing the ratios of step c) to those in control NSCLC cells comprises determining an R 2 value for each ratio; e) identifying the sample of NSCLC cells as being cisplatin-resistant based on the comparison of the ratios in step d), wherein the sample of NSCLC cells are identified as being cisplatin resistant when the R 2 value determined in step d) for each ratio is about 0.87 or greater; and f) selecting a treatment for NSCLC, wherein treatment not involving cisplatin is selected when the sample of NSCLC cells are identified as being cisplatin resistant in step e) and treatment involving cisplatin is selected when the R 2 value determined in step d) for any ratio is less than 0.87.