Patent ID: 8357517

Claim:
A method of assessing if a subject is at high risk of developing asthma, comprising: a) analyzing nucleic acid derived from said subject by performing a biological assay to determine whether the following polymorphic forms of the TLR7, CCL11, and CCL2 genes of said subject are present: i) a TLR7 gene (SEQ ID NO:1) comprising the single nucleotide polymorphism of rs179019 (SEQ ID NO:7); rs179020 (SEQ ID NO:8); or rs179017 (SEQ ID NO:9); ii) a CCL11 gene (SEQ ID NO:3) comprising the single nucleotide polymorphism of rs1129844 (SEQ ID NO:10); rs17735961 (SEQ ID NO:11); or rs4795895 (SEQ ID NO:12); and iii) a CCL2 gene (SEQ ID NO:5) comprising the single nucleotide polymorphism of: rs4586 (SEQ ID NO:13); b) correlating the frequency of combinations of said polymorphic forms with the likelihood said subject is at high risk of developing asthma wherein combinations comprising rs17735961 (SEQ ID NO: 11), rs 179019 (SEQ ID NO: 7), rs1129844 (SEQ ID NO:10) and rs 179020 (SEQ ID NO: 8) have a direct effect on asthma status and combinations comprising rs4795895 (SEQ ID NO: 12), rs179017 (SEQ ID NO: 9) and rs4586 (SEQ ID NO: 13) have an indirect effect on asthma through association with the other polymorphic forms.