Patent ID: 7655795

Claim:
A process for preparing a compound of the formula (I) wherein: V is selected from CH 2 and NH, and W is NR 1 ; or V is NR 1 , and W is selected from CH 2 and NH; X is selected from CH 2 and CHOH in the R or S-configuration, except where W is selected from NH and NR 1 , then X is CH 2 ; Y is selected from hydrogen, halogen and hydroxy, except where V is selected from NH and NR 1 , then Y is hydrogen; Z is selected from hydrogen, halogen, hydroxy, a sulfonate leaving group, SQ, OQ and Q, where Q is an alkyl, aralkyl, or aryl group; and R 1 is a radical of the formula (II) wherein: A is selected from CH and CR 2 , where R 2 is selected from halogen, alkyl, aralkyl, aryl, OH, NH 2 , NHR 3 , NR 3 R 4 and SR 5 , where R 3 , R 4 and R 5 are each alkyl, aralkyl or aryl groups; B is selected from OH, NH 2 , NHR 6 , SH, hydrogen and halogen, where R 6 is an alkyl, aralkyl or aryl group; D is selected from OH, NH 2 , NHR 7 , hydrogen, halogen and SCH 3 , where R 7 is an alkyl, aralkyl or aryl group; and E is N; including reacting a compound of the formula (III) wherein: V is selected from CH 2 and NH, and W is NH; or V is NH, and W is selected from CH 2 and NH; X is selected from CH 2 and CHOH in the R or S— configuration, except where W is NH, then X is CH 2 ; Y is selected from hydrogen, halogen and hydroxy, except where V is selected from NH, then Y is hydrogen; and Z is selected from hydrogen, halogen, hydroxy, a sulfonate leaving group, SQ, OQ and Q, where Q is an alkyl, aralkyl, or aryl group; with a compound of the formula (IV) wherein A, B, D, and E are as defined above; and with formaldehyde or a formaldehyde equivalent.