Patent ID: 8063084

Claim:
A compound of Formula (I): wherein: X is N; Y is S; Q is W is —N(R 6 )C(O)— or —R 8 —C(O)N(R 6 )—; V is a direct bond; n is 1, 2, or 3; p is 0, 1, 2, to 2n; R 1 is halo, hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; or R 1 is a multi-ring structure having 2 to 4 rings wherein the rings are independently cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other; R 2 is hydrogen, aryl, aralkyl, or heteroaryl; R 3 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, halo, haloalkyl, haloalkoxyl, cyano, or —N(R 6 ) 2 ; R 4 and R 4a are independently hydrogen, alkyl, haloalkyl, hydroxyl, hydroxyalkyl, alkoxy, cycloalkylalkyl or aralkyl; or R 4 and R 4a are together to form an oxo (═O) group or a cycloaklyl; each R 5 is independently alkyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, hydroxyalkyl, alkoxy, cycloalkylalkyl, aralkyl, —N(R 6 )C(O)R 2 , —C(O)N(R 6 )R 2 , —OC(O)N(R 6 )R 2 , —N(R 6 )C(O)OR 2 , —N(R 6 )C(O)N(R 6 )R 2 , —OR 2 , —SR 2 —, —N(R 6 )R 2 , —S(O) t R 2 , —N(R 6 )S(O) 2 R 2 , —S(O) 2 N(R 6 )R 2 , —OS(O) 2 N(R 6 )R 2 , —C(O)R 2 , —OC(O)R 2 , —C(O)OR 2 , —N(R 6 )C(═N(R 6a ))N(R 6 )R 2 , —N(R 6 )C(═S)N(R 6 )R 2 , —N(R 6 )((R 6a )N═)CR 2 , or —C(═N(R 6a ))N(R 6 )R 2 ; each R 6 is independently hydrogen, alkyl, hydroxyalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl or aralkyl; each R 6a is independently hydrogen, alkyl, cycloalkylalkyl, or cyano; each R 7 is independently hydrogen, alkyl, trifluoromethyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, hydroxyalkyl, cycloalkylalkyl or aralkyl; and R 8 is a direct bond; or a pharmaceutically acceptable salt thereof.