Patent ID: 7897593

Claim:
A compound of Formula I where: R 1 is (Ar 1 )alkyl; R 2 is hydrogen, alkyl, hydroxy, or alkoxy; R 3 is hydrogen, halo, hydroxy, cyano, alkyl, cycloalkyl, haloalkyl, alkoxy, haloalkoxy, CON(R 6 )(R 6 ), CON(R 11 )(R 12 ), SOR 7 , SO 2 R 7 , SO 2 N(R 6 )(R 6 ), SO 2 N(R 11 )(R 12 ), N(R 6 )(R 6 ), N(R 6 )(R 6 ), N(R 6 )COR 7 , N(R 6 )CO 2 R 7 , N(R 6 )SO 2 R 7 , PO(OR 6 ) 2 , R 16 , or Ar 2 ; R 4 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, or haloalkoxy; R 5 is hydrogen, halo, hydroxy, cyano, alkyl, alkoxy, haloalkyl, or haloalkoxy; R 6 is hydrogen or alkyl; R 7 is alkyl or cycloalkyl; R 8 and R 9 taken together is CH 2 N(R 10 )CH 2 , CH 2 N(R 10 )CH 2 CH 2 , CH 2 N(R 10 )CH 2 CH 2 CH 2 , CH 2 N(R 10 )CH 2 CH 2 CH 2 CH 2 , CH 2 CH 2 N(R 10 )CH 2 CH 2 , or CH 2 CH 2 N(R 10 )CH 2 CH 2 CH 2 ; R 10 is COR 6 , CO 2 (R 6 ), COCO 2 (R 6 ), CON(R 6 )(R 6 ), COCON(R 6 )(R 6 ), CO 2 (benzyl), CO(phenyl), SO 2 R 7 , SO 2 N(R 6 )(R 6 ), or SO 2 (phenyl) where the phenyl is substituted with 0-2 groups selected from alkyl, halo, haloalkyl, cyano, alkoxy, and haloalkoxy; or R 10 is tetrazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, furanyl, thienyl, or pyrrolyl, and is substituted with 0-2 substituents selected from the group consisting of oxo, halo, alkyl, and alkoxy; R 11 and R 12 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, (R 6 )-piperidinyl, piperazinyl, dialkylpiperazinyl, (R 13 )-piperazinyl, (R 13 )-dialkylpiperazinyl, homopiperidinyl, morpholinyl, dialkylmorpholinyl, or thiomorpholinyl; R 13 is alkyl, (cycloalkyl)alkyl, SO 2 R 14 , or COR 15 ; R 14 is hydrogen, alkyl, amino, alkylamino, dialkylamino, azetidinyl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperizinyl, (alkyl)piperizinyl, morpholinyl, or thiomorpholinyl; R 15 hydrogen, alkyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, azetidinyl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperizinyl, (alkyl)piperizinyl, morpholinyl, or thiomorpholinyl; R 16 azetidinonyl, pyrrolidinonyl, valerolactamyl, caprolactamyl, maleimido, oxazolidonyl, or dioxothiazinyl, and is substituted with 0-1 substituents selected from the group consisting of hydroxymethyl, acetoxymethyl, and aminomethyl; Ar 1 is Ar 2 is tetrazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, furanyl, thienyl, pyrrolyl, pyrimidinyl, pyrazinyl, pyridinyl, hydroxypyridinyl, quinolinyl, isoquinolinyl, or indolyl, and is substituted with 0-2 substituents selected from the group consisting of oxo, halo, alkyl, alkoxy, and N(R 6 )(R 6 ); X—Y—Z is C(R 8 )(R 9 )OCH 2 CH 2 ; or a pharmaceutically acceptable salt thereof.