Patent ID: 8182990

Claim:
A method for diagnosing or predicting susceptibility to open angle glaucoma in a human subject, comprising the steps of: i) obtaining a biological sample from the subject, ii) analyzing said sample to determine the presence or absence of a polymorphism in the noelin 2 gene that results in an arginine to glutamine change at amino acid position 144 of the noelin 2 protein; iii) analyzing said sample to determine the presence or absence of a polymorphism in the myocilin gene that results in a phenylalanine to leucine change at amino acid position 369 of the myocilin protein; and iv) making a diagnosis that said subject has, or is susceptible to, open angle glaucoma when said subject has at least one polymorphism selected from the group consisting of a polymorphism that results in a glutamine at amino acid position 144 of the noelin 2 protein and a polymorphism that results in a leucine at amino acid position 369 of the Myocilin protein.