Patent ID: 7455843

Claim:
A method of enhancing immune response to an antigen comprising co-administering intranasally to an individual (a) a mutant enterotoxin wherein the mutant enterotoxin is a mutant of the B subunit of E. coli LT-IIb and does not exhibit GD1a, GM2 and GM3 ganglioside binding activity as demonstrated by ganglioside-dependent enzyme-linked immunosorbent assay (ELISA), and wherein the mutant enterotoxin consists of the amino acid sequence of SEQ ID NO:6; and (b) the antigen, whereby the mutant enterotoxin acts as an adjuvant to enhance the immune response to the antigen, and wherein the immune response comprises a serum antibody response, a salivary antibody response, and a vaginal antibody response to the antigen.