Patent ID: 8466263

Claim:
An isolated human monoclonal antibody that immunospecifically binds to a carbonic anhydrase IX (G250) protein, wherein said antibody (a) has a heavy chain with a CDR1 comprising an amino acid sequence SYAMS (SEQ ID NO: 55); (b) has a heavy chain with a CDR2 comprising an amino sequence AISXXGGXTXXADSVKG (SEQ ID NO: 58); (c) has a heavy chain with a CDR3 comprising an amino sequence NGNYRGAFDI (SEQ ID NO: 65); (d) has a light chain with a CDR1 comprising an amino sequence TGSSSNIGAGYDVH (SEQ ID NO: 61); (e) has a light chain with a CDR2 comprising an amino sequence GNNNRPS (SEQ ID NO: 62); and (f) has a light chain with a CDR3 comprising an amino sequence QSYDSSLSAWVV (SEQ ID NO: 63), and wherein said antibody reduces carbonic anhydrase activity of said protein.