Patent ID: 7442554

Claim:
A method for evaluating the potential of a chemical entity to bind to a glucocorticoid receptor (GR) Site II comprising: (a) docking a chemical entity into the cavity circumscribed by said GR Site II, wherein said GR Site II is a structure defined by structure coordinates that describe conserved residue backbone atoms having a root mean square deviation of not more than 2.0 Å from the conserved residue backbone atoms described by the structure coordinates of amino acids E537-V543, L566, G567, Q570-W577, S599-A607, W610, R611, R614, Q615, P625, Y663, L664 and K667 of SEQ ID NO:1 according to Table I, Table IV or Table V; (b) analyzing structural and chemical feature complementarity between said chemical entity and said GR Site II; and (c) screening the chemical entity in an in vitro assay that characterizes binding to said GR Site II, thereby identifying the chemical entity that binds GR Site II.