Patent ID: 8541437

Claim:
A compound of the formula 1; or a pharmaceutically acceptable salt, or hydrate thereof: wherein R 1 is C 1 -C 5 alkyl; R 2 i is independently hydrogen, halogen, C 1 -C 3 alkyl, CF 3 , OCF 3 or OCH 3 ; i is 1, 2, 3, or 4; Ar is unsubstituted phenyl or substituted phenyl substituted with halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, a substituted amino group or trifluoromethyl; or Ar is a substituted or unsubstituted 6-membered aromatic heterocycle one or, with two nitrogen atoms in the heterocycle; and W is an ethenyl group or ethynyl group.