Patent ID: 7273946

Claim:
A compound of general formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof R—X—Y—ONO 2 (I) wherein R is the prostaglandin residue of formula (II): wherein the symbol represents a single bond or a double bond; L is selected from the following groups: X is —O—, —S— or —NH—; Y is a bivalent radical having the following meaning: a) straight or branched C 1 -C 20 alkylene, being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO 2 or T, wherein T is —OC(O)(C 1 -C 10 alkyl)—ONO 2 or —O(C 1 -C 10 alkyl)—ONO 2 ; cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with side chains T 1 , wherein T 1 is straight or branched C 1 -C 10 alkyl; wherein n is an integer from 0 to 20, and n 1 is an integer from 1 to 20; wherein X 1 =—OCO— or —COO— and R 2 is H or CH 3 ; Z is —(CH) n 1 — or the bivalent radical defined above under b) n 1 is as defined above and n 2 is an integer from 0 to 2; wherein: Y 1 is —CH 2 —CH 2 —(CH 2 ) n 2 —; or CH═CH—(CH 2 ) n 2 —; Z is —(CH) n 1 — or the bivalent radical defined above under b) n 1 , n 2 , R 2 and X 1 are as defined above; wherein: n 1 and R 2 are as defined above, R 3 is H or —COCH 3 ; with the proviso that when Y is selected from the bivalent radicals mentioned under b)-f), the —ONO 2 group is bound to —(CH 2 ) n 1 ; wherein X 2 is —O— or —S—, n 3 is an integer from 1 to 6 and R 2 is as defined above; wherein: n 4 is an integer from 0 to 10; n 5 is an integer from 1 to 10; R 4 , R 5 , R 6 , R 7 are the same or different, and are H or straight or branched C 1 -C 4 alkyl; wherein the —ONO 2 group is linked to wherein n 5 is as defined above; Y 2 is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, and is selected from