Patent ID: 7879545

Claim:
A method of generating a radiation classifier for determining cellular irradiation survival before exposure to the radiation in a carcinoma, glioma, melanoma, or adenocarcinoma comprising the steps of: establishing at least one survival fraction value of at least one cell line, wherein the one survival fraction value is established by determining the survival fraction of at least one cell line after exposure to 2 Gy of radiation, and wherein the survival fraction is defined as a continuous variable; establishing baseline gene expression profiles from the at least one cell line absent radiation exposure; selecting genes further comprising: correlating the baseline gene expression profiles of the at least one cell line with the cell survival fraction value to select genes indicative of cellular radiation survival using Significant Analysis of Microarrays; and applying the gene expression of the carcinoma, glioma, melanoma, or adenocarcinoma to the genes indicative of cellular survival fraction values to determine the cellular radiation survival of the carcinoma, glioma, melanoma, or adenocarcinoma using a linear regression model.