Patent ID: 8304416

Claim:
A method of treating a disease in which inhibition, regulation and/or modulation of PKB kinase, RAF kinase or Tie-2 tyrosine kinase signal transduction plays a role, comprising administering to a patient in need thereof an effective amount of a compound according to formula I or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said compound or said salt thereof and a pharmaceutically acceptable carrier wherein R 1 is —OH or —OA, R 2 is H, —OH, —OA, phenoxy, —O—CO-A, —OSO 3 H, —OSO 3 A, —OSO 2 A or Hal, R 3 is H, R 1 and R 2 together are alternatively methylenedioxy or ethylenedioxy, Het is chromen-2-onyl, benzothiazolyl, thienyl, pyridinyl, pyrimidinyl, pyrazinyl, indolyl, furyl, pyrrolyl, isoxazolyl, imidazolyl, thiazolyl, triazolyl, tetrazolyl, quinolyl or isoquinolyl, each of which is unsubstituted or mono- or disubstituted by Hal and/or A, and A is unbranched or branched alkyl having 1-6 carbon atoms, where 1-5 H atoms may be replaced by F.