Patent ID: 7045518

Claim:
Compound represented by the formula: or a pharmaceutically acceptable salt thereof, wherein t represents 0, 1 or 2; R 1 represents hydrogen, alkyl of 1–5 carbon atoms, alkenyl of 2–5 carbon atoms, alkynyl of 2–5 carbon atoms, hydroxyalkyl of 1–3 carbon atoms, alkoxyalkyl of 1–3 alkyl and 1–3 alkoxy carbon atoms, cyanoalkyl of 1–3 alkyl carbon atoms, —CH 2 CONH 2 , —CH 2 CH 2 CONH 2 , —CH 2 S(O) 2 NH 2 , —CH 2 SCH 3 , —CH 2 S(O)CH 3 or —CH 2 S(O) 2 CH 3 radicals; R 2 represents radicals of alkyl of 1–5 carbon atoms, aralkyl of 1–3 alkyl carbon atoms, alkylthioalkyl of 1–3 alkyl carbon atoms, arylthioalkyl of 1–3 alkyl carbon atoms or cyloalkylalkyl of 1–3 alkyl carbon atoms and 3–6 ring member carbon atoms; R 3 represents radicals of alkyl radical of 1–5 carbon atoms, cyloalkyl of 5–8 ring members or cycloalkylmethyl radical of 3–6 ring members; R 4 represents benzo fused 5 to 6 ring member heteroaryl or benzo fused 5 to 6 ring member heterocyclo radicals, or a radical of the formula wherein A and B each independently represent O, S, SO or SO 2 ; R 6 represents deuterium, alkyl of 1–5 carbon atoms, fluoro or chloro radicals; R 7 represents hydrogen, deuterium, methyl, fluoro or chloro radicals; or a radical of the formula wherein Z represents O, S or NH; and R 9 represents a radical of formula wherein Y represents O, S or NH; X represents a bond, O or NR 21 ; R 20 represents hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 2 to 5 carbon atoms, aralkyl of 1 to 5 alkyl carbon atoms, heteroaralkyl of 5 to 6 ring members and 1 to 5 alkyl carbon atoms, heterocycloalkyl of 5 to 6 ring members and 1 to 5 alkyl carbon atoms, aminoalkyl of 2 to 5 carbon atoms, N-mono-substituted or N,N-disubstituted aminoalkyl of 2 to 5 alkyl carbon atoms wherein said substituents are radicals of alkyl of 1 to 3 carbon atoms, aralkyl of 1 to 3 alkyl carbon atoms radicals, carboxyalkyl of 1 to 5 carbon atoms, alkoxycarbonylalkyl of 1 to 5 alkyl carbon atoms, cyanoalkyl of 1 to 5 carbon atoms or hydroxyalkyl of 2 to 5 carbon atoms; R 21 represents hydrogen radical or alkyl radical of 1 to 3 carbon atoms; or the radical of formula —NR 20 R 21 represents a 5 to 6 ring member heterocyclo radical; and R 22 represents alkyl radical of 1 to 3 carbon atoms or R 20 R 21 N-alkyl radical of 1 to 3 alkyl carbon atoms; and R 5 represents an alkyl radical of 1–5 carbon atoms, alkenyl radical of 2–5 carbon atoms, alkynyl radical of 2–5 carbon atoms or aryl substituted alkyl radical of 1–5 carbon atoms.