Patent ID: 8399634

Claim:
A method for preparing a compound having the structure: said method comprising steps of: (a) effecting glycosylation of a monosaccharide having the structure: wherein OX I represents a suitable leaving group for effecting the glycosylation; and R 2a and R 2b are each independently alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, aryl or heteroaryl; with a monosaccharide having the structure: wherein R 3 and R 4 are each independently a suitable oxygen protecting group; under suitable conditions to effect formation of a disaccharide having the structure: (b) deprotecting the disaccharide formed in step (a) under suitable conditions to effect formation of a partially deprotected disaccharide having the structure: (c) reacting the partially deprotected disaccharide formed in step (b) with a suitable reagent under suitable conditions to effect formation of a diphosphorylated disaccharide having the structure: wherein R 3a and R 3b are each independently alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, aryl or heteroaryl; and (d) treating the diphosphorylated disaccharide formed in step (c) with one or more suitable reagents under suitable conditions to effect formation of a disaccharide having the structure: