Patent ID: 8664217

Claim:
A benzodiazepine compound of Formula (1) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently or lower alkyl; R 2 and R 3 may be linked to form lower alkylene; A l is lower alkylene optionally substituted with one or more hydroxy; and R 5 is group represented by wherein X A and X B are each independently bond, lower alkenylene, —CO—, —SO 2 —, —SO 2 -lower alkylene, —CO-lower alkenylene, lower alkylene-N(lower alkyl)-CO-lower alkylene, lower alkylene-N(lower alkyl)-, lower alkylene-N(lower alkyl)-CO—or lower alkylene-O—, wherein R 6 and R 7 are each independently hydrogen, lower alkyl, cyclo lower alkyl, phenyl, naphthyl, furyl, thienyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, pyrrolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, imidazo[2,1-b]thiazolyl, thieno[2,3-b]pyrazinyl, 2,3-dihydroimidazo[2,1-b]thiazolyl, benzothiazolyl, indolyl, imidazo[1,2-a]pyridyl, benzothienyl, benzimidazolyl, 2,3-dihydrobenzo[b]furyl, benzofuryl, indazolyl, furo[2,3-c]pyridyl, furo[3,2-c]pyridyl, thieno[2,3-c]pyridyl, thieno[3,2-c]pyridyl, thieno[2,3-b]pyridyl, benzo[1,3]dioxolyl, benzisoxazolyl, pyrazolo[2,3-a]pyridyl, indolizinyl, 2,3-dihydroindolyl, isoquinolyl, 1,2,3,4-tetrahydro-1H-isoquinolyl, carbostyril, 3,4-dihydrocarbostyril, quinolyl, chromanyl, 5,6,7,8-tetrahydroisoquinolyl, 3,4-dihydro-1H-isoquinolyl, naphthyridinyl, 1,4-benzodioxanyl, cinnolinyl, quinoxalinyl, or 2,3-dihydrobenz-1,4-oxazinyl, each of which is optionally substituted.