Patent ID: 8163727

Claim:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which: X is C 1-2 alkyl which is substituted by one or more halogen atoms; A is independently selected from halogen, SO 2 NR 3 R 4 , SO n R 5 (n=1 or 2), CONR 3 R 4 , or C 1-3 alkyl which can be optionally substituted by one or more halogen atoms; E is CONR 3 R 4 where R 3 and R 4 together form a pyrrolidine, piperidine, azetidine or isoxazoline ring, each optionally substituted by halogen or C 1 -C 3 alkyl; D is hydrogen or fluorine; R 1 and R 2 independently represent a hydrogen atom, or a C 1-3 alkyl group; or R 1 and R 2 together can form a 3-8 membered ring optionally containing one or more atoms selected from O, S, NR 6 and itself optionally substituted by one or more C 1 -C 3 alkyl; R 3 and R 4 independently represent hydrogen, C 3 -C 7 cycloalkyl or C 1-6 alkyl, the latter two groups being optionally substituted by one or more substituents independently selected from halogen, C 3 -C 7 cycloalkyl, OR 6 and NR 7 R 8 ; or R 3 and R 4 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocylic ring optionally containing one or more atoms selected from O, S(O) n (where n=0, 1 or 2), NR 8 , and itself optionally substituted by halogen or C 1-3 alkyl; R 5 is C 1 -C 6 alkyl or C 3-7 cycloalkyl, which may be optionally substituted by halogen atoms; R 6 is hydrogen or C 1 -C 6 alkyl; R 7 and R 8 independently represent hydrogen, C 1 -C 6 alkyl or C 3-7 cycloalkyl or R 7 and R 8 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocyclic ring as defined above for R 3 and R 4 .