Patent ID: 6884890

Claim:
A method to prepare a compound or a salt of formula I, wherein R 1 is a substituted or unsubstituted aryl or heteroaryl, or a group of the formula CH═CH—R 3 or CH═N—R 3 , where R 3 is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 2 is Y—X, where Y is O, S, C═CH 2 , C═O, S═O, SO 2 , CH 2 , CHCH 3 , NH, or N-C 1 -C 8 alkyl); X is where R 9 is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxyl, aryloxyl, cycloalkoxyl, NH—(C 1 -C 8 alkyl), NH-(aryl), NH-(heteroaryl), N═CH-(alkyl), NH(C═O)R 11 , or NH 2 , where R 11 is selected from hydrogen, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and R 10 is independently selected from hydrogen, halogen, and lower-alkyl; the method comprising converting a compound of formula IX into a compound of formula X by a cross coupling reaction in the presence of a metal catalyst or a stoichiometric metal reagent: where Pg is a protecting group; and removing the protecting group to form the compound of formula I.