Patent ID: 7858792

Claim:
A compound of formula I: wherein: a is 0 or 1; R 1 is halo; b is 0 or 1; R 2 is halo; W represents O; c is 2; the two R 3 groups are joined to form (1-3C)alkylene; m is 0 or 1; R 4 is selected from hydrogen and (1-4C)alkyl; r is an integer from 2 to 4; R 5 is selected from hydrogen, (1-4C)alkyl, —C(O)(1-4C)alkyl, -(1-4C)alkyleneC(O)OR 5a , —C(O)heterocyclyl, —C(O)CH(NH 2 )(1-4C)alkyleneQ, -(1-4C)alkyleneC(O)Z, —C(O)(1-4C)alkyleneZ, and —S(O) 2 (1-4C)alkyleneZ; where Q is a nitrogen-containing substituent selected from —NR 5b R 5c and heteroaryl; Z is a nitrogen-containing substituent selected from —NR 5d R 5e and heterocyclyl; R 5a is hydrogen or (1-4C)alkyl; each of R 5b , R 5c , R 5d and R 5e independently represents hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl or hydroxyphenyl, and where (1-4C)alkyl is unsubstituted or substituted by 1 or 2 substituents selected independently from amido, cyano, furyl, hydroxyl, and methylimidazolyl; the heterocyclyl is selected from pyrrolidinyl, hydroxypyrrolidinyl, piperidyl, piperazinyl, tetrahydropyrimidinyl, and 1,4 diazepanyl, and is unsubstituted or substituted by 1 or 2 substituents selected independently from hydroxyl, amido, (1-4C)alkoxy, oxo, —S(O) 2 (1-4C)alkyl, —(CH 2 )O(1-4C)alkyl, -(1-4C)alkyleneOH, —NR 5f R 5g , and —C(O)NR 5h R 5i , where each of R 5f , R 5g R 5h and R 5i independently represents hydrogen or (1-4C)alkyl; and the heteroaryl is selected from pyridyl and imidazolyl; each R 6 independently represents halo or —OR 6a , where R 6a is hydrogen or (1-4C)alkyl; p is 0, 1 or 2; and X 1 is selected from (1-3C)alkylene, —C(O)(1-3C)alkylene, (1-3C)alkyleneC(O)—, —SO 2 —, —SO 2 (1-3C)alkylene and (1-3C)alkyleneSO 2 —; where the alkylene group in any X 1 is optionally substituted with 1 or 2 substituents independently selected from (1-4C)alkyl and —NR Xa R Xb ; wherein R Xa and R Xb are independently selected from hydrogen and (1-4C)alkyl; wherein the alkyl group in R 6a is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof.