Patent ID: 8481731

Claim:
A compound of the formula (I): wherein: X 1 , X 2 , X 3 , and X 4 are independently —N— or —C(R 5 )—; Y 1 is —N— and Y 2 —C(R 3 )—, or Y 1 is —C(R 3 )— and Y 2 is —N—; A is —N(R 7 )—; R 1 is R Alk , aryl-C 1-4 alkyl, heterocycle-C 1-4 alkyl, —C(═O)R 7 , —CO 2 R 6 , —SO 2 R 6 , —C(═O)N(R 7 ) 2 , —C(═S)N(R 7 ) 2 , aryl, or heterocycle, wherein each R A1k , alkyl, aryl and heterocycle are optionally substituted with 1-4 substituents independently of each other selected from R 9 ; R 2 at each occurrence is independently C 1-4 alkyl, F, hydroxy, or C 1-4 alky-O—; R 3 at each occurrence is independently H, halogen, CN, C 1-4 alkyl, C 1-4 alkyl-O— or C 1-4 alkyl-S—; R 4 at each occurrence is independently H, halogen, or C 1-4 alkyl; R 5 at each occurrence is independently H, halogen, cyano, hydroxy, R Alk , haloC 1-4 alkyl, —NO 2 , —C(═O)R 6 , —CO 2 R 6 , —C(═O)N(R 7 ) 2 , —SO 2 N(R 7 ) 2 , —S(═O)R 6 , —S(═O) 2 R 6 , C 1-6 alkyl-O—, haloC 1-4 alkyl-O—, —N(R 7 ) 2 , C 1-6 alkyl-S—, aryl, aryl-C 1-6 alkyl, heterocycle, heterocycle-C 1-6 alkyl, —NR 7 C(═O)R 6 , —NR 7 C(═O)N(R 7 ) 2 , —NR 7 C(═O)OR 7 , —NR 7 C(═NR 7 )N(R 7 ) 2 , or —NR 7 S(═O) 2 N(R 7 ) 2 wherein each R Alk , alkyl, aryl, and heterocycle are optionally substituted with 1-5 substituents independently of each other selected from R 9 ; R 6 is R Alk , heterocycle, heterocycle-C 1-3 -alkyl, or aryl, wherein each R Alk , alkyl, heterocycle and aryl is optionally substituted with 1-4 substituents independently of each other selected from R 9 ; R 7 at each occurrence is independently H or R Alk wherein each R Alk is optionally substituted with 1-4 substituents independently of each other selected from halogen, hydroxy, —N(R 8 ) 2 , C 1-4 alkyl-O—, and —CO 2 R 8 ; R 8 at each occurrence is independently H or C 1-4 alkyl; R 9 is at each occurrence is independently cyano, hydroxy, R Alk , aryl, aryl-C 1-3 -alkyl, heterocycle, halogen, oxo, C 1-4 haloalkyl, —NO 2 , —C(═O)H, —CO 2 R 8 , —OC(═O)R Alk , —C(═O)N(R 7 ) 2 , —SO 2 N(R 7 ) 2 , —S(═O)R Alk , —S(═O) 2 R Alk , C 1-6 alkoxy, haloC 1-4 alkoxy, —N(R 7 ) 2 , —SR 7 , —NR 7 C(═O)R Alk , —NR 7 C(═O)OR Alk or —NR 7 C(═O)N(R 7 ) 2 , wherein each R Alk , alkyl, aryl and heterocycle are optionally substituted with 1-4 substituents independently of each other selected from halogen, hydroxy, —N(R 8 ) 2 , C 1-4 alkyl-O—, —NR 7 CO 2 R 7 , —NR 7 SO 2 R 7 , and —CO 2 R 8 ; R Alk at each occurrence is independently C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-3 -alkyl, C 4-8 -cycloalkenyl or C 4-8 -cycloalkenyl-C 1-3 -alkyl; m is 0,1, or 2; n is 0,1, or 2; p is 0 or 1; and q is 0,1, or 2, a tautomer or stereoisomer thereof, or a salt thereof.