Patent ID: 7553618

Claim:
A method for determining whether an HIV-1 has an increased likelihood of being hypersusceptible to treatment with amprenavir, comprising detecting whether the protease encoded by said HIV exhibits the presence or absence of a mutation associated with hypersusceptibility to treatment with amprenavir at an amino acid position corresponding to position 39, 65, 69, or 89 of SEQ ID NO.: 1, wherein the mutation at the amino acid position corresponding to position 39 of SEQ ID NO.: 1 is S, the mutation at the amino acid position corresponding to position 65 of SEQ ID NO.: 1 is D, the mutation at the amino acid position corresponding to position 69 of SEQ ID NO.: 1 is K, and the mutation at the amino acid position corresponding to position 89 of SEQ ID NO.: 1 is M, and wherein the presence of said mutation indicates that the HIV has an increased likelihood of being hypersusceptible to treatment with amprenavir.