Patent ID: 7264973

Claim:
A method of detecting binding of one or more cells to one or more specific binding substances comprising: (a) immobilizing one or more specific binding substances to two or more distinct locations on an internal surface of a vessel, wherein the internal surface of the vessel comprises a colorimetric resonant reflectance optical biosensor; (b) illuminating the vessel with light; (c) detecting one or more peak wavelength values (PWVs) for each distinct location; (d) applying one or more cells to the internal surface of the vessel; (e) illuminating the vessel with light; (f) detecting one or more peak wavelength values (PWVs) for each distinct location; (g) comparing the PWV's of step (c) to the PWV's of step (f); wherein, if the one or more cells have bound to one or more specific binding substances, then the PWV is shifted at the distinct location to which the cells are bound.