Patent ID: 8288435

Claim:
A compound of formula (Ia), wherein the stereogenic centers are in absolute (1S,3S,5S)-configuration: wherein A represents aryl or heterocyclyl, wherein the aryl or heterocyclyl is unsubstituted or independently mono- or di-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 3-6 )cycloalkyl, (C 2-6 )alkinyl, (C 1-4 )alkoxy, NR 2 R 3 , halogen and unsubstituted or independently mono- or di-substituted phenyl or pyridyl, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, trifluoromethyl, trifluoromethoxy, fluorine and chlorine; B represents an aryl- or heterocyclyl-group, wherein the aryl or heterocyclyl is unsubstituted or independently mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, trifluoromethyl, â€”NR 2 R 3 , â€”NHSO 2 â€”(C 1-4 )alkyl, â€”N(R 2 )C(O)R 3 and halogen; n represents the integer 0 or 1; R 1 represents aryl or heterocyclyl, wherein the aryl or heterocyclyl is unsubstituted or independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, trifluoromethyl, (C 1-4 )alkyl-thio, (C 2-6 )alkinyl and â€”NR 2 R 3 ; or R 1 represents a 2,3-dihydro-benzofuranyl-, a benzo[1,3]dioxolyl-, a 2,3-dihydro-benzo[1,4]dioxinyl-, a 4H-benzo[1,3]dioxinyl-, a 2H-chromenyl, a chromanyl-, a 2,3-dihydro-thieno[3,4-b][1,4]dioxinyl-, a 3,4-dihydro-2H-benzo[1,4]oxazinyl-, or a 4-morpholino-phenyl-group wherein said groups are unsubstituted or mono- or di-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy and halogen; R 2 represents hydrogen or (C 1-4 )alkyl; and R 3 represents hydrogen or (C 1-4 )alkyl; or a pharmaceutically acceptable salt of such a compound.