Patent ID: 7226746

Claim:
A method for identifying an inhibitor of Non-Aβ Component of amyloid Precursor (NACP)/α-synuclein aggregation comprising: providing a test compound, a first sample and a second sample, wherein each sample comprises NACP/α-synuclein derived from the same source; inducing NACP/α-synuclein aggregation in the first sample and second sample by subjecting them to an iron-catalyzed oxidative condition, wherein the condition is achieved by adding an amount of exogenous ferric ion or exogenous ferrous ion and hydrogen peroxide effective to aggregate NACP/α-synuclein; exposing the first sample to the test compound; measuring an aggregation level of NACP/α-synuclein in the first sample and the second sample; and comparing the aggregation level of NACP/α-synuclein in the first sample and with the aggregation level of the second sample, wherein less aggregation in the first sample is indicative that the test compound is an inhibitor of NACP/α-synuclein aggregation.