Patent ID: 7115560

Claim:
A method of reducing gastric acid or pepsinogen secretion, comprising administering to an animal an amount of a prokineticin receptor antagonist effective to reduce one or more indicia of gastric acid or pepsinogen secretion, wherein said antagonist comprises an amino acid sequence having at least 80% identity to amino acids to 7 to 77 of SEQ ID NO: 3, said sequence comprising; (a) the 10 conserved cysteine residues of SEQ ID NO: 3, and (b) from 0 to 9 of amino acids 78 to 86 of SEQ ID NO: 3, wherein amino acids 1 to 6 preceeding that part of said antagonist having at least 80% identity to amino acids to 7 to 77 of SEQ ID NO: 3 do not consist of amino acids AVITGA (SEQ ID NO: 21).