Patent ID: 8193369

Claim:
Compound of formula (I) including any stereochemically isomeric form thereof, wherein n is an integer 0, 1 or 2; X is SO, SO 2 or N—(CO)—R 1 ; R 1 is hydrogen; C 1-6 alkyl; C 1-6 alkyloxy; C 1-4 alkyloxyC 1-4 alkyl; or polyhaloC 1-6 alkyl; R 2 is C 1-6 alkyl; R 3 is hydrogen, halo, C 1-4 alkyl, C 1-4 alkyloxy, trifluoromethyl or cyano; R 4 is C 1-8 alkyl; C 1-8 alkyl substituted with C 3-8 cycloalkyl; polyhaloC 1-8 alkyl; C 1-8 alkyl substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C 1-4 alkyloxy, polyhaloC 1-4 alkyloxy, cyano, nitro, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, aryl, or heteroaryl; C 3-8 cycloalkyl; C 3-8 cycloalkyl substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C 1-4 alkyloxy, polyhaloC 1-4 alkyloxy, cyano, nitro, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, aryl, or heteroaryl; tetrahydropyranyl, tetrahydrofuranyl, oxetanyl aryl; or heteroaryl; aryl is phenyl; or phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C 1-4 alkyl, polyhaloC 1-4 alkyl, C 1-4 alkyloxy, polyhaloC 1-4 alkyloxy, cyano, nitro, NR 5 R 6 , R 7 -carbonyl, R 7 —SO 2 —, or C 1-4 alkyl substituted with hydroxy, NR 5 R 6 , R 7 -carbonyl or R 7 —SO 2 —; heteroaryl is selected from from furanyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, or pyrazinyl; wherein R 5 and R 6 are independently from one another selected from hydrogen, C 1-4 alkyl, polyhaloC 1-4 alkyl, aminosulfonyl, or C 1-8 alkylsulfonyl; or R 7 -carbonyl, or; wherein R 5 and R 6 are taken together with the nitrogen atom bearing R 5 and R 6 may form a pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl ring; and wherein R 7 is C 1-4 alkyl, hydroxy, amino, mono- or di-(C 1-4 alkyl)amino, (hydroxyC 1-4 alkyl)amino, (C 1-4 alkyloxyC 1-4 alkyl)amino, di(C 1-4 alkyl)aminoC 1-4 alkyl, pyrrolidinyl, piperidinyl, morpholinyl, or N-methyl-piperazinyl; or a pharmaceutically acceptable acid addition salt thereof.