Patent ID: 8470332

Claim:
A polypeptide comprising an altered tenth fibronectin type III ( 10 Fn3) domain, wherein the altered 10 Fn3 domain (i) comprises a loop, AB; a loop, BC; a loop, CD; a loop, DE; a loop EF; and a loop FG; (ii) has at least one loop selected from loop BC, DE, and FG with an altered amino acid sequence relative to the sequence of the corresponding loop of the human 10 Fn3 domain having the amino acid sequence of SEQ ID NO: 1, and (iii) binds human insulin-like growth factor-I receptor (IGF-IR) with a disassociation constant of about 1 μM or less; wherein the altered 10 Fn3 domain comprises an amino acid sequence that is at least 80% identical to any one of SEQ ID NOs: 184-203.