Patent ID: 7695899

Claim:
A method for identifying chemotherapeutic agents comprising: (a) genotoxically stressing a DNA damage checkpoint deficient tissue; (b) genotoxically stressing a DNA damage checkpoint proficient tissue; (c) contacting said genotoxically-stressed tissues with a candidate agent; (d) determining whether said candidate agent reduces the survival or growth of at least part of said genotoxically-stressed DNA damage checkpoint deficient tissue relative to said genotoxically stressed DNA damage checkpoint proficient tissue whereby, a chemotherapeutic agent is identified as an agent that reduces survival or growth; wherein said DNA damage checkpoint deficient tissue and said DNA damage checkpoint proficient tissue are intact structures in an organism or structures removed from said organism or portions thereof, provided that the tissues are not single cells in culture; and wherein said DNA damage checkpoint deficient tissue comprises grp mutant tissue of Drosophila melanogaster , and said DNA damage checkpoint proficient tissue comprise grp wild-type Drosophila melanogaster tissue.