Patent ID: 8470572

Claim:
An isolated or recombinant polynucleotide encoding an engineered ketoreductase polypeptide which comprises an amino acid sequence that is (a) at least 90% identical to SEQ ID NO: 4 and in which the residue corresponding to X94 is threonine, the residue corresponding to X199 is alanine, histidine, or asparagine; and the residue corresponding to X202 is valine or leucine; or (b) at least 90% identical to SEQ ID NO: 66 and which comprises a set of mutations as compared to SEQ ID NO: 4 of any one of the polypeptide sequences of SEQ ID NO: 64, 66, 68, 70, 72, 74, 76, 78, 80, or 82.