Patent ID: 7011970

Claim:
An automatic bio-manipulation factory system for manipulating a single cell comprising: a bio-MEMS (Micro-Electra Mechanical System) that transports, separates and extracts a single cell for manipulation from a plurality of cells, said bio-MEMS comprises: an input unit that stores a plurality of inputted cells and transports the plurality of cells in a line by controlling the size of a cell transportation channel through the use of capillary electrophoresis caused by the application of a transportation voltage and a focus voltage; an injection unit including an injection port that separates cells for manipulation from the plurality of cells transported in a line by applying a separation voltage; an extraction unit that extracts one of the cells separated for manipulation by applying an extraction voltage and manipulates the rotation-orientation of the cell by applying a rotation-orientation voltage; and a drain unit that absorbs the remaining cells other that the cells separated for manipulation; and a micro manipulation system comprising: an inverted optical microscope that monitors the single cell in the bio-MEMS; a microstage which has a 3-degree of freedom to position the bio-MEMS in focus of the optical microscope; and an injection pipette for manipulation of the single cell.