Patent ID: 8076453

Claim:
A compound of formula (1) aa y -aa x -aa 0 -aa 1 -aa 2 -aa 3 -aa 4 -aa 5 -Ser 6 -Pro 7 -D-Phe 8 -X (1) or a salt thereof; wherein: X is OH or NH 2 ; aa y is Sar, acetyl or other acyl group; aa x is L-Arg, D-Arg, L-Lys, D-Lys, L-Orn, D-Orn, another basic amino acid of the L or D-configuration, L-Cit, D-Cit or is absent; aa 0 is L-Arg, D-Arg, L-Lys, D-Lys, L-Orn, D-Orn, another basic amino acid of the L or D-configuration, or L-Cit, D-Cit; aa 1 is L-Arg or D-Arg; aa 2 is L-Pro, L-Oic, another L-Pro mimic amino acid, L-Hyp, L-α-(Me)Pro or another Pro-mimic amino acid derivative chosen from 5,5-dimethylthiazolidine-4-carboxylic acid; 3,4-dehydro-proline; azetidine-2-carboxylic acid; trans-4-cyano-proline; cis-4-cyano-proline; 2-ethylthiazolidine-4-carboxylic acid; thiazolidine-2-carboxylic acid; 2-methylthiazolidine-4-carboxylic acid; and 3-phenylpyrrolidine-2-carboxylic acid; aa 3 is L-Pro, or another L-Pro-mimic amino acid, L-Hyp, L-Oic, L-α-(Me)Pro or another Pro-mimic amino acid derivative chosen from 5,5-dimethylthiazolidine-4-carboxylic acid; 3,4-dehydro-proline; azetidine-2-carboxylic acid; trans-4-cyano-proline; cis-4-cyano-proline; 2-ethylthiazolidine-4-carboxylic acid; thiazolidine-2-carboxylic acid; 2-methylthiazolidine-4-carboxylic acid; and 3-phenylpyrrolidine-2-carboxylic acid; aa 4 is Gly, ethyl amine, or Aib; aa 5 is L-Phe, D-Phe, Acc, L-Cha, D-Cha, L-Chg, D-Chg, L-Cpg, D-Cpg, L-Igl, D-Igl, L-Pen, D-Pen, L-4Bip, D-4Bip, L-Phg, D-Phg, L-Thi, or D-Thi; and D-Phe 8 is D-Phe; or -aa 2 -aa 3 -aa 4 - is an aliphatic ω-amino carboxyl residue with a chain length of 8 carbon atoms; and X, aa y , aa x , aa 0 , aa 1 , aa 5 , and D-Phe 8 are as previously defined; or -aa 2 -aa 3 -aa 4 -aa 5 - is an aliphatic ω-amino carboxyl residue with a chain length of 11 carbon atoms; and X, aa y , aa x , aa 0 , aa 1 , and D-Phe 8 are as previously defined.