Patent ID: 8168568

Claim:
A method for selecting a combination of therapeutic agents for individualized treatment of a disease in a patient caused by an abnormal network of interconnected cell signaling proteins that leads to an aberrant cellular response in the patient, comprising: measuring activity states for a plurality of different signaling proteins extracted from diseased cells obtained from a tissue of the patient; determining whether the activity states measured for the plurality of signaling proteins extracted from the diseased cells are different from activity states for corresponding signaling proteins from reference cells to detect differences between the activity states of individual signaling proteins from the diseased cells and the activity states of the corresponding individual signaling proteins from the reference cells, thereby providing a snapshot of the signaling proteins in the diseased cells that form an abnormal network of interconnected cell signaling proteins that leads to the aberrant cellular response in the patient; and selecting a combination of at least two different therapeutic agents for the patient to reduce the difference that was detected in the activity states of two or more of the signaling proteins in the network of interconnected cell signaling proteins from the activity states of the corresponding signaling proteins in the reference cells.