Patent ID: 7678790

Claim:
A compound of formula (I): wherein: A is thienyl; optionally substituted with halogen or cyano; W is phenylene, optionally substituted with halogen; E is selected from the group consisting of H, —C 1 -C 8 alkyl, polyhaloalkyl, —C 3-8 -cycloalkyl, aryl, alkylaryl and heteroaryl; D is —NR 1 —(C═O)—R 2 ; R 1 independently selected from the group consisting of: H, —C 1 -C 8 alkyl, polyhaloalkyl, —C 3 -C 8 -cycloalkyl, aryl, alkylaryl, heteroaryl, —(C═O)—C 1 -C 8 alkyl, —(C═O)-aryl, and —(C═O)-heteroaryl; R 2 is independently selected from the group consisting of aryl, and heteroaryl, optionally substituted with lower alkoxy, lower alkylamino or halogen; each heteroaryl is independently selected from the group consisting of acridinyl, azocinyl benzimidazolyl benzofuranyl benzothiofuranyl benzothiophenyl benzoxazolyl, benzthiazolyl, benztriazolyl benztetrazolyl benzisoxazolyl benzisothiazolyl benzimidazalinyl carbazolyl 4aH-carbazolyl, chromanyl chromenyl, cinnolinyl, furanyl furazanyl, imidazolidinyl imidazolinyl imidazolyl, 1H-indazolyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl (benzimidazolyl), isothiazolyl, isoxazolyl, morpholinyl, naphthyridinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl-1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxazolidinyl, pyrimidinyl, phenanthridinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrazinyl, pyroazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pryidooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolinyl 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, 6H-1,2,5-thiadazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl-1,2,5-thiadiazolyl-1,3,4-thiadiazolyl, thianthrenyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl triazinyl 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl 1,3,4-triazolyl and xanthenyl; R 1 and R 2 can be direct linked or can be indirectly linked through a carbon chain that is from 1 to about 8 carbon atoms in length; Y is selected from the group consisting of O, S, N—OR 5 , and NR 5 , R 5 is selected from the group consisting of: H, C 1-10 alkyl, C 3-8 -cycloalkyl, and CN; or pharmaceutically acceptable salts.