Patent ID: 7504500

Claim:
A process for preparing a compound of formula I in which R is Hal or C≡CH, R 1 is H, ═O, Hal, A, OH, OA, A—COO—, A—CONH—, A—CONA—, N 3 , NH 2 , NO 2 , CN, COOH, COOA, CONH 2 , CONHA, CON(A) 2 , O-allyl, O-propargyl, O-benzyl, ═N—OH or ═N—OA, R 2 is H, Hal or A, R 3 is 2-oxopiperidin-1-yl, 2-oxopyrrolidin-1-yl, 2-oxo-1H-pyridin-1-yl, 3-oxomorpholin-4-yl, 4-oxo-1H-pyridin-1-yl, 2-oxo-1H-pyrazin-1-yl, 2-oxoimidazolidin-1-yl, 2-iminopiperidin-1-yl, 2-iminopyrrolidin-1-yl, 3-iminomorpholin-4-yl, 2-imino-imidazolidin-1-yl, 2-imino1H-pyrazin-1-yl, 2,6-dioxopiperidin-1-yl, 2-oxopiperazin-1-yl, 2,6-dioxopiperazin-1-yl, 2,5-dioxopyrrolidin-1-yl, 2-oxo-1,3-oxazolidin-3-yl, 3-oxo-2H-pyridazin-2-yl, 2-caprolactam-1-yl (=2-oxoazepan-1-yl), 2-azabicyclo[2.2.2]octan-3-on-2-yl, 5,6-dihydro-1H-pyrimidin-2-oxo-1-yl, 2-oxo-1,3-oxazinan-3-yl or 4H-1,4-oxazin-4-yl, which is optionally mono- or disubstituted by A or OA, A is unbranched, branched or cyclic alkyl having 1-10 carbon atoms, in which 1-7 H atoms are optionally replaced by F, Hal is F, Cl, Br or I, or a pharmaceutically acceptable salt, mono- or dihydrate, alcoholate or stereoisomer thereof, comprising a) reacting a compound of formula II in which R 1 is as defined above, with a compound of formula III in which R is as defined above, to give a compound of formula IV in which R and R 1 are as defined above, b) then reacting the compound of formula IV with a compound of formula V in which R 2 and R 3 are as defined above, to give a compound of formula I, and c) optionally converting the compound of formula I into a pharmaceutically acceptable salt, mono- or dihydrate or alcoholate thereof by converting a base or acid of the compound of formula I into one of its salts, or by bringing together the compound of formula I with water or an alcohol.