Patent ID: 6908930

Claim:
A compound of Formula 1 or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 is H or methyl; each of R 2 and R 3 is independently H, halogen, (C 1 -C 3 )alkyl, or (C 1 -C 3 )alkoxy; or R 2 and R 3 taken together form an optionally substituted methylindene selected from the group consisting of; wherein: n is an integer of 0-3; each R 7 is independently H, alkyl, carboxylic acid, amine, halogen, nitro, cyano, X 1 , X 2 —(C-C 4 )alkyl-R 8 , X 2 —(C 1 -C 4 )alkenyl-R 8 , or X 2 —(C 1 -C 4 )alkynyl-R 8 ; X 1 is —C(O)NR 9 —, —NR 9 C(O)—, —C(O)O—, C(O)R 11 , —OC(O)—, —O—, —NR 9 —, —S—, —S(O 2 ), or —S(O 2 )NR 9 —; X 2 is a chemical bond, —C(O)NR 9 —, —NR 9 C(O)—, —C(O)O—, C(O)R 11 , —OC(O)—, —O—, —NR 9 —, —S—, —S(O 2 ), or —S(O 2 )NR 9 —; R 8 is selected from the group consisting of hydrogen, dialkylamino, carboxyl, hydoxyl, alkoxy, sulfonamide, urea, carbamate, diol, alkylsulphonyl, and R 10 ; R 9 is H or (C 1 -C 3 )alkyl; R 10 is an optionally substituted 5- or 6-membered saturated, unsaturated, or aromatic heterocycle comprising from 1 to 4 heteroatoms; and R 11 is an optionally substituted 5- to 6-membered saturated heterocyclic ring; R 4 is H, methyl, trifluoromethyl, (C 1 -C 4 )alkyl, alkoxy, amido, amino, or optionally substituted aryl; X is a chemical bond, ethynyl, —O—, —S—, —S(O)—, —S(O 2 )—, —NR 5 C(O)—, or —NR 5 —, wherein R 5 is H, methyl, or substituted methylene; Y is a 5- to 10-membered mono or bicyclic, saturated, unsaturated, or aromatic ring comprising 0-3 heteroatoms and optionally substituted; and Z is N or CR 6 , wherein R 6 is H, halogen, nitro, cyano, alkoxyl, sulfonamide, amino, or amide.