Patent ID: 7847105

Claim:
A method of making a compound (I) or a salt thereof, wherein R 1 and R 2 are each independently H, alkyl, —C(O)OR′, —C(O)NR′R″, or a protecting group, wherein R′ and R″ are independently selected from the group consisting of H, substituted alkyl, unsubstituted alkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted heterocycloalkyl, and unsubstituted heterocycloalkyl; R 6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy; and X is halogen, the method comprising: adding protecting groups R 1′ and R 2′ to a compound (II), wherein R 1′ and R 2′ are different protecting groups, to form a compound (III) wherein R 3 is alkyl; and generating a five membered ring comprising the amine nitrogen of compound (III).