Patent ID: 8293772

Claim:
A compound of general formula Ia or Ib wherein R 1 is methyl, chloro, bromo, or methoxy; R 2 is chloro or methyl; R 3 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 1-6 alkoxycarbonyl, ureido, thioureido, C 1-6 alkylcarbonyloxy, C 1-6 alkoxycarbonyloxy, C 1-6 alkoxysulfonyloxy, C 1-6 alkoxycarbamoyl, or C 1-6 aminocarbonyl, each of which is optionally substituted with one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, CONH 2 , nitro, oxo, —S(O) 2 NH 2 , C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy, C 1-4 alkoxycarbonyl, ureido, thioureido, C 1-4 alkylcarbonyloxy, C 1-4 alkoxycarbonyloxy, C 1-4 alkoxysulfonyloxy, C 1-4 alkoxycarbamoyl, C 1-4 aminocarbonyl, C 1-4 alkylthio, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, amino, imino, C 1-4 aminosulfonyl, C 1-4 aminocarbonyloxy, C 1-4 alkylsulfonylamino, C 1-4 alkoxyimino, C 1-4 alkylcarbonylamino, C 1-4 alkylsulfonyl or 5- or 6-membered C 2-5 heterocycloalkyl comprising 1-3 heteroatoms selected from O or N, wherein said C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy, C 1-4 alkoxycarbonyl, ureido, thioureido, C 1-4 alkylcarbonyloxy, C 1-4 alkoxycarbonyloxy, C 1-4 alkoxysulfonyloxy, C 1-4 alkoxycarbamoyl, C 1-4 aminocarbonyl, C 1-4 alkylthio, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, amino, imino, C 1-4 aminosulfonyl, C 1-4 aminocarbonyloxy, C 1-4 alkylsulfonylamino, C 1-4 alkoxyimino, C 1-4 alkylcarbonylamino, C 1-4 alkylsulfonyl or 5- or 6-membered C 2-5 heterocycloalkyl comprising 1-3 heteroatoms selected from O or N, are optionally further substituted with one or more, same or different substituents selected from the group consisting of halogen, hydroxy, —NH 2 , mercapto, trifluoromethyl, cyano, carboxy, CONH 2 , nitro, oxo, —S(O) 2 NH 2 , C 1-4 alkyl, or C 1-4 hydroxyalkyl, or R 3 represents hydrogen, or hydroxy, R 4 , R 5 , R 6 , R 7 , and R 8 independently of each other represent hydrogen, halogen, —NH 2 , hydroxy, trifluoromethyl, methoxy, ethoxy, methyl, or ethyl; provided that the compound is not [4-(2-aminophenyl)amino)-2-chlorophenyl]-[2-methyl-541-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-1H-1,2,3-triazol-4-yl]-phenyl]-methanone or [4-[(2-aminophenyl)amino]-2-chlorophenyl]-[5-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]-2-methylphenyl]-methanone; or a pharmaceutically acceptable salt, or ester thereof.