Patent ID: 8088586

Claim:
A method of producing a body fluid sample depeleted of anti-MIIC Class II antibodies the method comprising: a. contacting the body fluid sample with one or more recombinant MHC Class II molecules or one or more recombinant MHC-type Class II molecules that bind anti-MHC Class II antibodies in the body fluid sample; b. removing the bound anti-MHC Class II antibodies from the body fluid sample; and, c. testing the body fluid sample produced in step b) by contacting the sample with a solid support comprising discrete sites, each site comprising recombinant MHC Class II molecules representing a specific, individual MHC Class II antigen, and detecting the binding or absence of binding of antibodies to the recombinant MHC Class II molecules at each site; whereby a body fluid sample depleted of antibodies binding to particular MHC Class II molecules is produced.