Patent ID: 8067549

Claim:
An isolated humanized antibody, or an antigen binding fragment thereof, that binds sphingosine-1-phosphate (S1P) and comprising at least one heavy chain variable domain and at least one light chain variable domain, wherein: A. each heavy chain variable domain comprises: (i) a first sequence of amino acid residues of sequence DHTIH (SEQ ID NO: 13); (ii) a second sequence of amino acid residues AISPRHDITKYNEMFRG (SEQ ID NO: 31); and (iii) a third sequence of amino acid residues of sequence GGFYGSTIWFDF (SEQ ID NO: 15); and B. each light chain variable domain comprises: (i) a first sequence of amino acid residues of sequence ITTTDIDDDMN (SEQ ID NO: 10); (ii) a second sequence of amino acid residues of sequence EGNILRP (SEQ ID NO: 11); and (iii) a third sequence of amino acid residues of sequence LQSDNLPFT SEQ ID NO: 12).