Patent ID: 8569234

Claim:
A topical composition for the transdermal delivery of an active agent, wherein the active agent is [Nle 4 , D-Phe 7 ]-alpha MSH, and wherein the composition comprises: (a) at least one non-aqueous non-toxic solvent selected from the group consisting of lower aliphatic mono- and poly-hydroxy compounds; (b) limonene, lemon oil, or a mixture of limonene and lemon oil; (c) methylsulfonylmethane; (d) a solute modifier comprising at least one compound selected from the group consisting of 3,3′-thiodipropionic acid or an ester or salt thereof, an oxindole alkaloid, a polyphenolic flavonoid, a sugar adduct of a gluconuride, an isoflavone, phosphatidyl serine, phosphatidyl choline, Vitamin D 3 and Vitamin K 1 ; (e) at least one substance which induces in situ generation of cAMP or cGMP, wherein the at least one substance comprises forskolin; and (f) a skin stabilizer comprising at least one compound selected from the group consisting of an aliphatic carboxylic acid having from about 8 to about 32 carbon atoms, an ester of said aliphatic carboxylic acid with an aliphatic alcohol having from to about 20 carbon atoms wherein said ester has a total of from about 9 to about 36 carbon atoms, and Vitamin D 3 , and wherein the composition further comprises one or more absorption modifiers selected from isopropyl myristate and benzophenone.