Patent ID: 8507559

Claim:
A compound of formula (I): or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from —COOH or —C(═O)NHSO 2 R 12 ; R 2 is H or C 1-6 alkyl; R 4 is H, C 1-4 alkyl, C 1-4 alkoxy, or aryl wherein the C 1-4 alkyl, C 1-4 alkoxy and aryl may be optionally substituted with one or more R 4a 's; R 4a is independently —OH, C 1-4 alkoxy, —NHC(═O)C 1-6 alkyl, aryl, or aryloxy; R 6 is selected from H, —OH or C 1-4 alkyl; R 12 is C 1-6 alkyl, haloC 1-6 alkyl or aryl; T is H, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, or halo; W is H, C 1-4 alkyl, haloC 1-4 alkyl, halo or aryl; X is H, C 1-4 alkyl, C 1-4 alkoxy, or halo; Y is H, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, halo or aryl; Z is selected from H, Cl, C 1-2 alkyl and C 1-2 alkoxy; or alternatively any two adjacent T, W, X, Y and Z can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring, which may be optionally substitute with one or more R 4a 's; provided that: (1) R 2 , R 4 , T, W, X, Y and Z are not all H; (2) X is not propyl or t-butyl when R 2 , T, W, X, Y and Z are H and R 4 and R 6 are methyl; (3) R 4 is not methyl or phenyl, when R 2 , T, Y and Z are H, R 6 is methyl, and X and W are both chloro; (4) W and Y are not both aryl; or (5) the compound is not