Patent ID: 7648989

Claim:
A compound of formula I wherein R a is H; C 1-4 alkyl; or C 1-4 alkyl substituted by OH, NH 2 , NHC 1-4 alkyl or N(di-C 1-4 alkyl) 2 ; one of R b , R c , R d and R e is halogen; C 1-4 alkoxy; C 1-4 alkyl; CF 3 or CN and the other three substituents are each H; or R b , R c , R d and R e are all H; and R is a radical of formula (a), (b) or (c) wherein R 1 is —(CH 2 ) n —NR 3 R 4 , wherein each of R 3 and R 4 , independently, is H or C 1-4 alkyl; or R 3 and R 4 form together with the nitrogen atom to which they are bound a heterocyclic residue; n is 0, 1 or 2; and R 2 is H; halogen; C 1-4 alkyl; CF 3 ; OH; SH; NH 2 ; C 1-4 alkoxy; C 1-4 alkylthio; NHC 1-4 alkyl; N(di-C 1-4 alkyl) 2 , CN, alkyne or NO 2 ; wherein each of R 10 and R 10a , independently, is a heterocyclic residue; or a radical of formula α —X—R f —Y (α) wherein S is a direct bond, O, S or NR 11 wherein R 11 is H or C 1-4 alkyl, R f is C 1-4 alkylene or C 1-4 alkylene wherein one CH 2 is replaced by CR x R y wherein one of R x and R y is H and the other is CH 3 , each of R x and R y is CH 3 or R x and R y form together —CH 2 —CH 2 —, Y is bound to the terminal carbon atom and is selected from OH, —NR 30 R 40 wherein each of R 30 and R 40 , independently, is H, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkyl, aryl-C 1-4 alkyl, heteroaryl-C 1-4 alkyl, C 2-6 alkenyl or C 1-4 alkyl optionally substituted on the terminal carbon atom by OH, halogen, C 1-4 alkoxy or —NR 50 R 60 wherein each of R 50 and R 60 , independently, is H, C 1-4 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkyl, aryl-C 1-4 alkyl, or R 30 and R 40 form together with the nitrogen atom to which they are bound a heterocyclic residue; and each of R 20 and R 20a , independently, is H; halogen; C 1-4 alkyl; C 1-4 alkoxy; CF 3 ; nitrile; nitro or amino; or a salt thereof.