Patent ID: 7902328

Claim:
An isolated, non-fibrillar, soluble oligomer comprising an Aβ(X-42) fragment, Aβ(X-43) fragment, or Aβ(X-44) fragment, where X is 10 to 24, wherein said oligomer is produced by a process comprising the steps of: (a) exposing a monomeric Aβ(1-42) protein, Aβ(1-43) protein or Aβ(1-44) protein to a detergent to form an oligomer A; (b) reducing the detergent action and continuing to incubate the oligomer A to form an oligomer B; and (c) proteolytically cleaving the (1-42) oligomer B, Aβ(1-43) oligomer B or Aβ(1-44) oligomer B.