Patent ID: 8388601

Claim:
A method of performing ocular surgery while preventing capsular opacification comprising the steps of: (i) filling the anterior chamber of the eye with a first aqueous viscoelastic agent; (ii) surgically removing the defective lens from the capsular bag; iii) introducing a second viscoelastic agent with one or more active agents that effectively prevents capsular opacification whereby the second viscoelastic agent in combination with the active agent is dissimilar to the first aqueous viscoelastic agent, wherein the second viscoelastic agent in combination with the active agent is homogenously distributed in the capsular bag, wherein said active agent is selected from the group consisting of a cytotoxic agent, an anti-proliferative agent, a cell growth inhibiting agent, and mixtures thereof and further wherein the homogenous distribution of the second viscoelastic agent and the one or more active agents is accomplished by mixing a dry viscoelastic compound and the at least one active agent with a method selected from the group consisting of (a) mixing a viscoelastic compound in dry form with a solution of the active agent, (b) mixing using particle aggregation techniques, and then placing the homogeneous mixture in solution, (c) spray coating the viscoelastic compound in dry form with the active agent, and then placing the coated viscoelastic compound in solution, (d) fluidized bed pelletizing, and then placing the pellets into solution, (e) container blending the dry viscoelastic compound with the active agent to form a homogeneous mixture, and then placing the mixture in solution, (f) forming a homogeneous mixture using fluid bed granulation, and then placing the mixture in solution, (g) using fluid bed coating to form a homogeneous mixture of dry viscoelastic compound and active agent, and then placing the mixture in solution (h) spheronizing the dry viscoelastic compound and active agent to form a homogeneous mixture, and then placing the mixture in solution, (i) using dram coating to form a homogeneous mixture of dry viscoelastic compound and active agent, and then placing the mixture in solution, (j) using sieve technology to form a homogeneous mixture of dry viscoelastic compound and active agent, and then placing the mixture in solution, (k) using wet granulation to form a homogeneous mixture of dry viscoelastic compound and active agent, and then placing the mixture in solution, (n) using semi-continuous granulation to form a homogeneous mixture of dry viscoelastic compound and active agent, and then placing the mixture in solution, and (m) using fluid bed drying to form a homogeneous mixture of dry viscoelastic compound and active agent, and then placing the mixture in solution; (iv) contacting the inner wall of the capsular bag with said second viscoelastic agent for a time sufficient to effectively kill or inactivate remaining epithelial cells; and (v) removing the second viscoelastic agent.