Patent ID: 7189712

Claim:
A compound of Formula (II): or a salt, solvate, or physiologically functional derivative thereof; wherein: m is 1, 2, 3, or 4; p is 0, 1, 2, 3, 4, or 5; R is independently selected from the group consisting of halo, C 1 –C 6 alkyl, C 2 –C 6 alkynyl, C 1 –C 6 alkoxy, —NR 1 R 2 , C 1 –C 4 haloalkyl, hydroxy, —C(O)R 1 , —OC(O)R 1 , —C(O)NR 1 R 2 , —S(O) 2 R 1 , C 1 –C 6 alkylsulfanyl, cyano, C 1 –C 2 halalkoxy, and the group defined by —(Y) o —(Y 1 ) r —(Y 2 ); wherein: Y is O and o is 0 or 1; Y 1 is C(H)(R′), and r is 0, 1, 2, 3, or 4; and Y 2 is aryl, heteroaryl, heterocyclic, C 3 –C 7 cycloalkyl, or C 2 –C 6 alkenyl; Q is independently selected from the group consisting of halo, C 1 –C 4 haloalkyl, C 1 –C 6 alkyl, C 1 –C 6 alkoxy, C 1 –C 4 haloalkoxy, hydroxy, aralkoxy, C 1 –C 6 alkenyl, alkynyl, C 1 –C 4 hydroxyalkyl, cyano, aryloxy, C 1 –C 2 halalkoxy, —NO 2 , —C(O)OR 1 , and the group defined by -(Z) q -(Z 1 ) r -(Z 2 ), wherein: Z is NH and q is 0 or 1; or Z is CH 2 and q is 0, 1, 2, or 3; or Z is O(CH 2 ) n where n is 1, 2, 3, or 4 and q is 0 or 1; Z 1 is S(O) 2 or C(O); and r is 0 or 1; and Z 2 is C 1 –C 6 alkyl, aryl, heteroaryl, heterocyclic, hydroxy, halo, aralkyl, C 1 –C 2 haloalkyl, C(H)(R′)R 3 , NH(CH 2 ) n NR 1 R 2 , NH(CH 2 ) n R 3 , NH(CH 2 ) n OR 1 or NR 1 R 2 , where n is 1, 2, 3, or 4; wherein when p is 2, each Q is independently selected from the group consisting of C 1 –C 6 alkoxy, hydroxyl, and the group defined by -(Z) g -(Z 1 ) r -(Z 2 ), wherein at least one Q is the group -(Z) g -(Z 1 ) r -(Z 2 ) and: Z is CH 2 and q is 0, 1, 2, or 3; or Z is O(CH 2 ) n where n is 1, 2, 3, or 4 and q is 0 or 1; Z 1 is S(O) 2 ; and r is 1; and Z 2 is C 1 –C 6 alkyl, aryl, heteroaryl, heterocyclic, halo, aralkyl, C 1 –C 2 haloalkyl, C(H)(R′)R 3 , NH(CH 2 ) n NR 1 R 2 , NH(CH 2 ) n R 3 , NH(CH 2 ) n OR 1 or NR 1 R 2 , where n is 1, 2, 3, or 4; R 1 is hydrogen, C 1 –C 4 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, aryl, heteroaryl, C 3 –C 7 cycloalkyl, heterocyclic, or aralkyl; R 2 is hydrogen, C 1 –C 4 alkyl, C 2 –C 6 alkenyl, C 2 –C 6 alkynyl, aryl, heteroaryl, C 3 –C 7 cycloalkyl, heterocyclic, or aralkyl; R 3 is heteroaryl or heterocyclic, and R′ is hydrogen or C 1 –C 3 alkyl.