Patent ID: 8703097

Claim:
A composition for imaging of a biological tissue, said composition comprising: a) two or more separate and unlinked signal modifying agents, each of said agents being specific for at least one imaging modality and each of said agents being specific for a different imaging modality; and b) a colloidal carrier comprising said two or more signal modifying agents wherein said carrier retains a sufficient amount of said agents for a time sufficient to acquire in vivo imaging data from each of the two or more signal modifying agents using said composition, and said colloidal carrier is a liposome comprising at least one lipid, cholesterol, and at least one pegylated lipid; and wherein said composition is specific for two or more imaging modalities selected from magnetic resonance imaging (MRI), X-ray, positron emission tomography (PET), computed tomography (CT), autoradiography, single-photon emission computed tomography (SPECT), fluoroscopy, optical imaging, fluorescence imaging, bioluminescence imaging and combinations thereof and each of the signal modifying agents is present at a different concentration that is sufficient to acquire in vivo imaging data from an imaging modality for which said signal modifying agent is specific, wherein said composition comprises i) a signal modifying agent specific for MRI comprising gadoteridol and a signal modifying agent specific for CT comprising iohexol, ii) a signal modifying agent specific for optical imaging comprising a fluorophore and a signal modifying agent specific for CT comprising iohexol or iii) a signal modifying agent specific for optical imaging comprising a fluorophore and a signal modifying agent specific for MRI comprising gadoteridol.