Patent ID: 8765699

Claim:
A double-stranded RNA compound the structure of which is: 5′ ugaagggugaaauauucuc 3′ (antisense strand) (SEQ ID NO: 48) 3′ acuucccacuuuauaagag 5′ (sense strand) (SEQ ID NO: 25) wherein each of a, c u, and g is a ribonucleotide and each consecutive ribonucleotide is joined to the next ribonucleotide by a covalent bond; and wherein alternating ribonucleotides in both the antisense and sense strands and the sense strand are 2′-O-Methyl sugar modified ribonucleotides and a 2′-O-Methyl sugar modified ribonucleotide is present at both the 5′ terminus and the 3′ terminus of the antisense strand and and unmodified ribonucleotide is present at both the 5′ terminus and the 3′ terminus of the sense strand, or a pharmaceutically acceptable salt thereof.