Patent ID: 7833742

Claim:
A method for selecting a human α-Gal A preparation having a desired pharmacokinetic parameter, the method comprising: obtaining or providing a first test α-Gal A preparation; and determining if the first test α-Gal A preparation has each of the characteristics (1)-(7): (1) has at least about 75% neutral, mono- and di-sialylated glycans combined; (2) has less than about 35% tri- and tetra-sialylated glycans combined; (3) has greater than 50% complex glycans; (4) has less than about 45% phosphorylated glycans; (5) has greater than about 45% sialylated glycans; (6) has a ratio of sialic acid to mannose-6-phosphate on a mole per mole basis greater than 1.5 to 1; and (7) has a ratio of sialylated glycans to phosphorylated glycans greater than 1, and selecting the first test α-Gal A preparation if it has each of the characteristics (1)-(7), wherein a human α-Gal A preparation having each of the characteristics (1 )-(7) is predicted to have the desired pharmacokinetic parameter, to thereby select a human α-Gal A preparation having the desired pharmacokinetic parameter.