Patent ID: 7112589

Claim:
A compound of formula I, or a pharmaceutically acceptable salt thereof wherein R is H, —R4, —OR4 or NR3R4, wherein R3 is H, lower alkyl or C 3 to C 10 cycloalkyl, and R4 is lower alkyl or C 3 to C 10 cycloalkyl, wherein R3 and R4 are independently, optionally substituted by halo, hydroxy, lower alkoxy, CN, NO 2 , or optionally mono- or di-lower alkyl substituted amino; R1 is —CO—NR5R6, —NH—CO—R5, —CH 2 —NH—C(O)—R5, —CO—R5, —S(O)—R5, —S(O) 2 —R5, —CH 2 —CO—R5 or —CH 2 —NR5R6, wherein R5 is aryl, aryl-lower alkyl, C 3 –C 10 cycloalkyl, C 3 –C 10 cycloalkyl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl, R6 is H, aryl, aryl-lower alkyl, aryl-lower-alkenyl, C 3 –C 10 cycloalkyl, C 3 –C 10 cycloalkyl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl, or wherein R5 and R6 together with the nitrogen atom to which they attached are joined to form an N-heterocyclyl group, wherein N-heterocyclyl denotes a saturated, partially unsaturated or aromatic nitrogen containing heterocyclic moiety attached via a nitrogen atom thereof having from 3 to 8 ring atoms optionally containing a further 1, 2 or 3 heteroatoms selected from N, NR7, O, S, S(O) or S(O) 2 wherein R7 is H or optionally substituted lower alkyl, carboxy, acyl, amido, aryl, S(O) or S(O) 2 , and wherein the N-heterocyclyl is optionally fused in a bicyclic structure, and wherein the N-heterocyclyl is optionally linked in a spiro structure with a 3 to 8 membered cycloalkyl or heterocyclic ring wherein the heterocyclic ring has from 3 to 10 ring members and contains from 1 to 3 heteroatoms selected from N, NR6, O, S, S(O) or S(O) 2 wherein R6 is as defined above, and wherein heterocyclyl denotes a ring having from 3 to 10 ring members and containing from 1 to 3 heteroatoms selected from N, NR7, O, S, S(O) or S(O) 2 wherein R7 is as defined above, and wherein R5 and R6 are independently, optionally substituted by one or more groups, selected from halo, hydroxy, oxo, lower alkoxy, CN and NO 2 , or optionally substituted by mono- or di-lower alkyl substituted amino, lower alkoxy, aryl, aryl-lower alkyl, N-heterocyclyl or N-heterocyclyl-lower alkyl wherein the optional substitution consists of from 1 to 3 substituents selected from halo, hydroxy, lower alkoxy, lower alkoxy-lower alkyl, lower alkoxy-carbonyl CN, and NO 2 , R2 is is independently H, or optionally substituted with lower alkyl, aryl, aryl-lower alkyl, C 3 –C 10 cycloalkyl, C 3 –C 10 cycloalkyl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl, and wherein R2 is optionally substituted by halo, hydroxy, oxo, lower alkoxy, CN, NO 2 , or optionally mono- or di-lower alkyl substituted amino.