Patent ID: 8759520

Claim:
A compound of the formula (I): wherein X is (CH 2 ) m optionally substituted with one or more substituents selected from the group consisting of methyl and ethyl, when m is 1; or X is (CH 2 ) m optionally substituted with one or more substituents selected from the group consisting of methyl, ethyl, OH and halo, when m is 2, 3 or 4; m is an integer from 1 to 4; R 1 is R 7 , OR 7 , SR 7 , NHR 7 R 7 is H, aryl or heteroaryl optionally substituted with halo, —NO 2 , —CN, —R 8 , —OR 8 , —C(O)OR 8 , —C(O)R 8 , —C(O)N(R 8 ) 2 , —C(O)NHSO 2 R 8 , —SOR 8 , —SO 2 R 8 , —SO 2 N(R 8 ) 2 , —N(R 8 ) 2 , —NR 8 C(O)R 8 , each R 8 is independently H or C 1 -C 4 alkyl; Y is (CH 2 ) n n is an integer from 1 to 6; R 3 , R 4 , R 5 and R 6 are each independently selected from hydrogen, halogen, C 1 -C 6 alkyl, —OR 14 , —C(O)N(R 14 ) 2 , —S(O)R 14 , —S(O) 2 R 14 , —S(O) 2 N(R 14 ) 2 , —N(R 14 ) 2 , —NR 14 C(O)R 14 , —C(O)OR 14 , —C(O)R 14 , —SR 14 , NO 2 and CN; R 14 is hydrogen or C 1 -C 6 alkyl, phenyl or a 5- or 6-membered heteroaryl group, wherein the alkyl, phenyl and heteroaryl groups may optionally be substituted with one or more substituents chosen from halo, CF 3 , CN, NO 2 , OCH 3 , and, for phenyl and heteroaryl groups, C 1 -C 4 alkyl; and R 2 is a group R 10 , where R 10 is a 5- or 6-membered aryl or heteroaryl group substituted by a group R 12 , where R 12 is a 5- or 6-membered carbocyclic or heterocyclic group, —(C 1 -C 4 alkyl)(C 5 -C 6 carbocyclyl) or —(C 1 -C 4 alkyl)(C 5 -C 6 heterocyclyl) which, in turn is optionally substituted by a group R 13 ; R 13 is -carbocyclyl, -heterocyclyl, -aryl, -heteroaryl, —C 1 -C 6 alkyl(carbocyclyl), —C 1 -C 6 alkyl(heterocyclyl), -C 1 -C 6 alkyl(aryl) or —C 1 -C 6 alkyl(heteroaryl), which is optionally substituted with one or more substituents chosen from halo and C 1 -C 6 alkyl, -carbocyclyl, -heterocyclyl, -aryl, -heteroaryl, any of which may optionally be substituted with one or more substituents chosen from halo, CN, NO 2 , O(C 1 -C 4 alkyl) and C 1 -C 4 alkyl; or a tautomer or pharmaceutically acceptable salt thereof.