Patent ID: 7964607

Claim:
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: R is selected from the group consisting of (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C6)alkynyl, (C 3 -C 8 )cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, each of which optionally may be substituted with one to three substituents, the substituents being independently selected from the group consisting of (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, halo, and (C 1 -C 4 )haloalkyl, R 1 is selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, (C 1 -C 4 )haloalkyl, and cyclopropyl; R 2 is selected from the group consisting of (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )haloalkyl, heteroaryl selected from the group consisting of pyridinyl, pyridazinyl, pyrimidinyl, and pyrazinyl, and ER 5 , wherein the heteroaryl optionally may be substituted with one to three substituents independently selected from the group consisting of (C 1 -C 4 )alkyl and (C 1 -C 4 )haloalkyl; R 3 is selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, (C 3 -C 6 )cycloalkyl, and (C 1 -C 4 )haloalkyl; E is selected from the group consisting of —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, and —C(O)—; R 5 is selected from the group consisting of (C 3 -C 8 )cycloalkyl, heterocycloalkyl, aryl, aryloxy, and heteroaryl, any of which optionally may be substituted with one to three substituents, such substituents being independently selected from the group consisting of (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 3 -C 8 )cycloalkyl, halo, cyano, phenyl, morpholinyl, (C 1 -C 4 )alkylamino, pyrazolyl, triazolyl, and imidazolyl.