Patent ID: 7087405

Claim:
An isolated nucleic acid molecule comprising a nucleic acid sequence chosen from the group consisting of: (a) a nucleic acid sequence encoding an immunoglobulin heavy chain polypeptide comprising a heavy chain variable region comprising complementarity determining regions (CDRs) having the amino acid sequences shown in residues 31–35, 50–66 and 99–107 of SEQ ID NO: 2, wherein said polypeptide when operatively combined with an immunoglobulin light chain polypeptide comprising a light chain variable region comprising CDRs having the amino acid sequences shown in residues 24–34, 50–56 and 89–97 of SEQ ID NO: 7 forms an antigen-combining region that binds the α v subunit of α v β 3 and α v β 5 ; and (b) a nucleic acid sequence that is fully complementary to the entirety of said nucleic acid sequence encoding an immunoglobulin heavy chain polypeptide.