Patent ID: 8728514

Claim:
A transdermal preparation of a layered structure for a non-steroidal anti-inflammatory drug comprising: a backing layer ( 1 ) located at the highest part of the layered structure and having a flexibility; a hydrophobic adhesive layer ( 2 ) placed below the backing layer; and a drug adhesive layer ( 3 ) placed below the hydrophobic adhesive layer, wherein the hydrophobic adhesive layer ( 2 ) is free of the drug and contains a hydrophobic adhesive to prevent water absorbed from skin from being lost and the drug contained in the drug adhesive layer ( 3 ) from being reverse-transferred to the backing layer ( 1 ), wherein the hydrophobic adhesive is selected from a group consisting of a polyisobutylene adhesive, a styrene-isoprene-styrene adhesive and a styrene-butadiene-styrene adhesive, wherein the drug adhesive layer ( 3 ) contains the non-steroidal anti-inflammatory drug, an acrylic adhesives for adhering the transdermal preparation to the skin and a hydrophilic polymer resin for promoting the water absorption from the skin, wherein the hydrophilic polymer resin is polyvinyl pyrrolidone or polyethyleneglycol, the total drug adhesive layer comprising 0.2-6 wt % polyvinyl pyrrolidone when the hydrophilic polymer resin is polyvinyl pyrrolidone, or 1-8 wt % polyethyleneglycol when the hydrophilic polymer resin is polyethyleneglycol, and wherein the non-steroidal anti-inflammatory drug is one or more selected from a group consisting of ketoprofen, diclofenac, flurbiprofen and felbinac.