Patent ID: 8524765

Claim:
A method of treating rheumatoid arthritis or ulcerative colitis in a mammal comprising administering to the mammal a compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein: R 1 is hydrogen; R 2 is aryl, benzothienyl, benzofuranyl, or —CH 2 CH 2 -phenyl; wherein R 2 is optionally substituted with 1 or 2 substituents independently selected from F, Cl, Br, I, —CN, —NO 2 , —CF 3 , —OCF 3 , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 6 heterocycloalkyl, phenyl, —NHS(═O) 2 R 8 , —S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 8 , —N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —CON(R 9 ) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 2 R 8 R 4 is an aryl, wherein the aryl is substituted with 1 or 2 substituents selected from F, Cl, Br, I, —CN, —NO 2 , —CF 3 , —OCF 3 , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 6 heterocycloalkyl, phenyl, —NHS(═O) 2 R 8 , S(═O) 2 N(R 9 ) 2 , —C(═O)CF 3 , —C(═O)NHS(═O) 2 R 8 , —S(═O) 2 NHC(═O)R 9 , N(R 9 ) 2 , —N(R 9 )C(═O)R 8 , —CO 2 R 9 , —C(═O)R 8 , —OC(═O)R 8 , —C(═O)N(R 9 ) 2 , —SR 8 , —S(═O)R 8 , and —S(═O) 2 R 8 ; each R 8 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; and each R 9 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl.