Patent ID: 7208496

Claim:
A compound of Formula I: wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are hydrogen, lower alkyl, or —C(O)R; in which R is —OR 9 or —NR 12 R 13 , where R 12 and R 13 are hydrogen or lower alkyl; or R 1 and R 2 , R 3 and R 4 , R 5 and R 6 , R 7 and R 8 , when taken together with the carbon to which they are attached, represent carbonyl, with the proviso that the maximum number of carbonyl groups is 2; R 9 is aryl, or benzyl and may be optionally substituted with 1 to 3 substituents selected from acetyl, alkyl, cyano, phenyloxy, cycloalkyl, hydroxy, alkoxy, halogen, halogen substituted alkyl, halogen substituted alkoxy, morpholino, and phenyl, wherein the phenyl, phenyloxy, and cycloalkyl substituents can be further substituted with 1 to 3 substituents selected from alkyl, alkoxy, hydroxy, halogen, and CF 3 ; R 11 is benzothiazolyl optionally substitated with 1 to 3 substituents selected from acetyl, alkyl, hydroxy, alkoxy, halogen, halogen substituted alkyl, phenyl, and phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF 3 ; R 10 is hydrogen or lower alkyl; T is oxygen, sulfur, or ═NR 16 , in which R 16 is hydrogen, lower alkyl, cyano, lower alkoxy, or C(O)OR 17 , in which R 17 is lower alkyl; Y is alkylene of 1–3 carbon atoms; and Z is —O—, —S—, —N(R 18 )— where R 18 is hydrogen or lower alkyl, or a covalent bond.