Patent ID: 8008341

Claim:
A benzsulfonamide according to formula I its geometrical isomers, in an optically active form as enantiomers, diastereomers, racemates, or pharmaceutically acceptable salts thereof, wherein Ar 1 is selected from the group consisting of an unsubstituted aryl group, an unsubstituted heteroaryl group, a substituted aryl group, and a substituted heteroaryl group; R 1 is hydrogen or a C 1 -C 6 -alkyl group; R 2 is hydrogen, —COOR 3 , —CONR 3 R 3′ , OH, a C 1 -C 4 alkyl substituted with an OH group, a hydrazido carbonyl group, a sulfate, a sulfonate, an amine or an ammonium salt; n is either 0 or 1; Y is a pyrrolidinyl group represented by the following formula: whereby, L 1 is selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 4 -C 8 -cycloalkyl optionally containing 1-3 heteroatoms and optionally fused with aryl or heteroaryl, aryl, heteroaryl, aryl-C 1 -C 6 -alkyl, heteroaryl-C 1 -C 6 -alkyl, —C(O)—OR 3 , —C(O)—R 3 , —C(O)—NR 3′ R 3 , —NR 3′ R 3 , —NR 3′ C(O)R 3 , —NR 3′ C(O)NR 3′ R 3 , —(SO)R 3 , —(SO 2 )R 3 , —NHSO 2 R 3 , and —SO 2 NR 3′ R 3 , with R 3 , R 3′ being substituents independently selected from the group consisting of H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, aryl, heteroaryl, aryl-C 1 -C 6 -alkyl, and heteroaryl-C 1 -C 6 -alkyl; and R 6 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, OH, halogen, nitro, cyano, sulfonyl, and oxo (═O), and n′ is an integer from 0 to 4.