Patent ID: 8476315

Claim:
A compound having the following general structural formula I, wherein: R 3a and R 3b together are selected from ═O, ═NR a , ═N—O—R a ; or R 3a and R 3b are independently from one another selected from hydrogen, —O—R a , —O—C(═O)—R a , —NH—R a , —NH—O—R a , —NH—C(═O)—R a and —NH—S(═O) 2 R a ; and R 11a and R 11b together are selected from ═O, ═NR a , ═N—O—R a ; or R 11a and R 11b are independently from one another selected from hydrogen, —O—R a , —O—C(═O)—R a , —NH—R a , methyl, ethyl, ethynyl, fluorine, chlorine, and bromine; and a single or double bond is present at 12-13; R 31 is selected from hydrogen, hydroxyalkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-8 alkynyl, —CF 3 , —(CH 2 ) n —C 6-14 aryl, —CH═CH—C 6-14 aryl, —C≡C—C 6-14 aryl, —(CH 2 ) n —C 5-14 heteroaryl, —CH═CH—C 5-14 heteroaryl, —C≡C—C 5-14 heteroaryl, carboxylic acid, —(CH 2 ) n —C 3-8 cycloalkyl, —CH═CH—C 3-8 cycloalkyl and —C≡C—C 3-8 cycloalkyl; and R 32 is hydrogen or selected from optionally substituted hydroxyalkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-8 alkynyl, —CF 3 , —(CH 2 ) n —C 6-14 aryl, —CH═CH—C 6-14 aryl, —C≡C—C 6-14 aryl, —(CH 2 ) n —C 5-14 heteroaryl, —CH═CH—C 5-14 heteroaryl, —C≡C—C 5-14 heteroaryl, carboxylic acid, —(CH 2 ) n —C 3-8 cycloalkyl, —CH═CH—C 3-8 cycloalkyl and —C≡C—C 3-8 cycloalkyl; R a is selected from hydrogen, hydroxyalkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-8 alkynyl, —CF 3 , —(CH 2 ) n —C 6-14 aryl, —CH═CH—C 6-14 aryl, —C≡C—C 6-14 aryl, —(CH 2 ) n —C 5-14 heteroaryl, —CH═CH—C 5-14 heteroaryl, —C≡C—C 5-14 heteroaryl, carboxylic acid, —(CH 2 ) n —C 3-8 cycloalkyl, —CH═CH—C 3-8 cycloalkyl and —C≡C—C 3-8 cycloalkyl; and each n independently of one another denotes 0, 1 or 2, including pharmaceutically effective salts, solvates, prodrugs, tautomers, racemates, enantiomers, diastereomers and mixtures thereof, with the proviso that compounds (3S, 18R, 20S)-3-(acetyloxy)-N-hydroxy-11-oxo-olean-12-en-29-amide and (3S, 18R, 20S)-3-(hydroxy)-N-hydroxy-11-oxo-olean-12-en-29-amide are not encompassed.