Patent ID: 8916570

Claim:
A compound of formula (V): R 301 is selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl C 1 -C 6 alkyl, C 3 -C 8 dicycloalkyl C 1 -C 6 alkyl, C 7 -C 12 bicycloalkyl C 1 -C 6 alkyl, C 7 -C 14 tricycloalkyl C 1 -C 6 alkyl, C 6 -C 14 aryl, C 6 -C 14 aryl C 1 -C 6 alkyl, C 6 -C 14 diaryl C 1 -C 6 alkyl, C 6 -C 14 aryl C 1 -C 6 alkoxy, heterocyclyl C 1 -C 6 alkyl, heterocyclyl, 4-[[[4-[[[(2-amino C 1 -C 6 alkyl)amino]-carbonyl]-C 1 -C 6 alkyl]anilino]carbonyl]C 1 -C 6 alkyl]C 6 -C 14 aryl, and C 6 -C 14 aryl C 3 -C 8 cycloalkyl, wherein the aryl or heterocyclyl portion of R 301 is optionally substituted with one or more substituents selected from the group consisting of halo, amino, hydroxyl, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 14 aryloxy, hydroxy C 1 -C 6 alkyl, hydroxy C 2 -C 6 alkenyl, hydroxy C 2 -C 6 alkynyl, carboxy C 1 -C 6 alkyl, carboxy C 2 -C 6 alkenyl, carboxy C 2 -C 6 alkynyl, aminocarbonyl C 1 -C 6 alkyl, aminocarbonyl C 2 -C 6 alkenyl, aminocarbonyl C 2 -C 6 alkynyl, and any combination thereof; and the alkyl or cycloalkyl portion of R 301 is optionally substituted with one or more substituents selected from the group consisting of halo, amino, alkyl, alkoxy, aryloxy, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, aminocarbonylalkoxy, and arylalkoxy, and any combination thereof; R 302 is C 6 -C 16 aryl or heteroaryl; wherein the aryl group is optionally substituted with one or more substituents selected from the group consisting of halo, amino, alkyl, aryl, carboxyl, SO 3 H, carboxyalkyl, sulfonyloxyalkyl, alkylcarbonyl, and arylcarbonyl; and the heteroaryl group is optionally substituted with one or more substituents selected from the group consisting of halo, amino, alkyl, carboxyl, SO 3 H, carboxyalkyl, sulfonyloxyalkyl, alkylcarbonyl, and arylcarbonyl; R 303 and R 304 are independently selected from the group consisting of hydroxyl, amino, mercapto, ureido, C 1 -C 6 alkyl carbonylamino, hydroxy C 1 -C 6 alkyl, and hydrazinyl; and R 305 is selected from the group consisting of hydrogen, C 1 -C 3 alkyl aminocarbonyl, di(C 1 -C 3 alkyl)aminocarbonyl, C 1 -C 3 alkylthio C 1 -C 3 alkyl, halo C 1 -C 3 alkyl, hydrazinyl, amino C 1 -C 3 alkyl, hydroxy C 1 -C 3 alkyl, C 3 -C 6 cycloalkylamino, hydroxylamino, and C 2 -C 3 alkenyl; R 306 is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, heteroaryl, and C 1 -C 6 aminoalkyl; n is 0-6; or a pharmaceutically acceptable salt thereof.