Patent ID: 7981930

Claim:
A kit for treating a patient wherein said patient has an influenza virus infection, is suspected of being infected with influenza, has a symptom associated with an influenza virus infection, or is at risk of exposure to an influenza virus, said kit comprising: a) an M2 inhibitor selected from amantadine and rimantadine in an amount that is antivirally effective in the combination; b) ribavirin in an amount that is antivirally effective in the combination, and c) a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, wherein the M2 inhibitor and ribavirin are provided in amounts that achieve drug concentrations that increase sensitivity of an influenza virus to the NAi by at least 2-fold over sensitivity of the virus to the NAi when used as a monotherapy, as measured in an in vitro dose response assay using influenza-infected MDCK cells.