Patent ID: 7825260

Claim:
A compound of formula I wherein R 1 is C 1-6 alkyl; C 1-6 alkyl substituted by hydroxy, C 1-2 alkoxy, or 1 to 6 fluorine atoms; C 2-6 alkenyl; or C 2-6 alkynyl; X is O, CH 2 , C═O or a direct bond; R 2 is optionally substituted C 1-7 alkyl, optionally substituted C 1-7 alkenyl, optionally substituted C 1-7 alkinyl, optionally substituted C 3-6 cycloalkyl, optionally substituted phenyl, or optionally substituted heteroaryl, where the substituted C 1-7 alkyl, C 1-7 alkinyl or C 3-6 cycloalkyl has 1 to 5 substituents selected from hydroxyl, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxy substituted by 1 to 5 halogen atoms, C 3-6 cycloalkoxy, cyano, phenyloxy, heteroaryl and optionally substituted phenyl; and wherein the optionally substituted phenyl or optionally substituted heteroaryl, independently, may be substituted with 1 to 5 substituents selected from hydroxyl, halogen, C 1-4 alkyl, C 1-4 alkyl substituted by 1 to 5 fluorine atoms, C 1-4 alkoxy, C 1-4 alkoxy substituted by 1 to 5 fluorine atoms, cyano and phenyl; R 3 is Z—X 2 , where Z is CH 2 , CHF or CF 2 , and X 2 is OH or a residue of formula (a) wherein Z 1 is a direct bond, CH 2 , CHF, CF 2 or O, and each of R 6 and R 7 , independently, is H, C 1-4 alkyl optionally substituted by 1, 2 or 3 halogen atoms, or benzyl; and each of R 4 and R 5 , independently, is H or C 1-4 alkyl optionally substituted by 1, 2 or 3 halogen atoms; and the anellated rings a and b together form 2,6- or 2,7-disubstituted naphthyl, 2,5- or 2,6-disubstituted benzoxazolyl, 2,5- or 2,6-disubstituted benzofuryl, 1,4- or 1,5-disubstituted indolyl, 3,6-indazolyl, or 3,6-N-substituted-indazolyl; where heteroaryl, where mentioned, refers to a 5-to-8-membered aromatic ring comprising 1 to 4 heteroatoms selected from N, O and S; in free form or in pharmaceutically-acceptable salt form.