Patent ID: 7244735

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ring B is selected from Z 1 is nitrogen; Z 2 is C-T (m) R y , wherein T (m) R y is N(R) 2 , halogen, OH, 3–6 membered carbocyclyl, or an optionally substituted group selected from C 1-6 aliphatic, a 6 membered aryl ring, or a 5–6 membered heteroaryl ring having 1–3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Q is selected from a saturated or unsaturated C 1-4 alkylidene chain wherein: up to two methylene units of the chain are optionally and independently replaced by —C(O)—, —C(O)C(O)—, —C(O)NR—, —C(O)NRNR—, —CO 2 —, —OC(O)—, —O—, —NRC(O)NR—, —OC(O)NR—, —NRNR—, —NRC(O)—, —S—, —SO—, —SO 2 —, —NR—, —SO 2 NR—, or —NRSO 2 —; each R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group, or: two R on the same nitrogen are taken together with the nitrogen to form a 5–8 membered heterocyclyl or heteroaryl ring having 1–3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each Ar is an optionally substituted ring selected from a 6–10 membered aryl ring, a 5–10 membered heteroaryl ring having 1–4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 3–10 membered heterocyclyl ring having 1–4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R 1 selected from CN, R, Ar, —(CH 2 ) y CH(R 4 )R 5 , or —(CH 2 ) y CH(R 4 )CH(R 5 ) 2 ; each y is independently 0–6; U is selected from a —O—, —S—, —N(R)—, or a C 1-6 alkylidene chain wherein up to two methylene units of U are optionally and independently replaced by —O—, —S—, —SO—, —SO 2 —, —N(R)SO 2 —, —SO 2 N(R)—, —N(R)—, —CO—, —CO 2 —, —N(R)CO—, —N(R)C(O)O—, —N(R)CON(R)—, —N(R)SO 2 N(R)—, —N(R)N(R)—, —C(O)N(R)—, or —OC(O)N(R)—; R 2 is selected from (CH 2 ) y CH(R 5 ) 2 or (CH 2 ) y CH(R 4 )CH(R 5 ) 2 ; y is 0–6; R 3 is selected from oxo, R, F, Cl, N(R) 2 , OR, SR, NRC(O)R, NRC(O)N(R) 2 , C(O)N(R) 2 , SO 2 R, NRSO 2 R, C(O)R, CN, SO 2 N(R) 2 , N(R)O, ON(R), or N(R)N(R); p is 0–4; R 4 is selected from R, (CH 2 ) w OR, (CH 2 ) w N(R) 2 , or (CH 2 ) w SR; w is 0–4; and each R 5 is independently selected from optionally substituted C 1-6 aliphatic, Ar, (CH 2 ) w OR, CO 2 R, (CH 2 ) w N(R) 2 , N(Ar)(R), (CH 2 ) w SR, NRC(O)R, NRC(O)N(R) 2 , C(O)N(R) 2 , SO 2 R, NRSO 2 R, C(O)R, CN, or SO 2 N(R) 2 .