Patent ID: 8029794

Claim:
A composition comprising a combination of neutralizing antibodies, wherein said combination of neutralizing antibodies comprises an antibody that immunospecifically binds toll-like receptor 4 (TLR4) and an antibody that immunospecifically binds toll-like receptor 2 (TLR2), wherein the anti-TLR4 antibody is an antibody having a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 41 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 44; and wherein the anti-TLR2 antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 56 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 59; wherein the anti-TLR4 antibody and the anti-TLR2 antibody are present in an amount that is effective to produce synergistic inhibition of bacterial-induced IL-6 production in a solution comprising whole blood where the bacteria is added to the whole blood solution at a concentration of 10 6 cfu/ml, as compared to the level of bacterial-induced IL-6 production in the whole blood solution in the absence of the combination of antibodies.