Patent ID: 8207195

Claim:
A method of treating nociceptive pain, the method comprises the steps of first identifying a subject suffering from nociceptive pain, then administering to the subject an effective amount of a compound of Formula II to treat nociceptive pain; wherein: Q is (CR 4 R 5 ) n3 ; n 1 is 1; n 2 is 1; n 3 is 0, 1, 2, or 3; R 2 is R 2 -2, optionally substituted: Ar is indazole; X is from 1 to 3 substituents on Ar, each independently in the form Y—Z, in which Z is attached to Ar; Y is one or more substituents on Z, and each is independently OR 8 , NR 8 R 9 , NO 2 , SR 8 , SOR 8 , SO 2 R 8 , SO 2 NR 8 R 9 , NR 8 SO 2 R 9 , OCF 3 , CONR 8 R 9 , NR 8 C(═O)R 9 , NR 8 C(═O)OR 9 , OC(═O)NR 8 R 9 , or NR 8 C(═O)NR 9 R 10 , Z is alkyl, alkenyl, alkynyl, aryl, or cycloalkyl; R 3 -R 5 are independently H, alkyl, or cycloalkyl, optionally substituted; R 8 -R 10 are independently H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, or heterocycle.