Patent ID: 8153133

Claim:
A method for preventing a disease caused by respiratory syncytial virus (RSV) in a patient at risk of such disease, comprising administering to the patient an antibody that specifically binds to the F protein of a RSV, wherein the antibody: (a) has an association rate constant (k on ) of at least 2.5×10 5 M −1 s −1 as measured by surface plasmon resonance; and (b) comprises the following complementarity determining regions (CDRs) with one or more amino acid changes at the underlined and bolded positions in one or more of the CDRs: heavy chain variable region (VH) CDR1 T S GMSVG; (SEQ ID NO: 8) VH CDR2 DIWWD D K KD YNPSLK S ; (SEQ ID NO: 9) VH CDR3 S MI T N W YFDV; (SEQ ID NO: 10) light chain variable region (VL) CDR1 SA SS S VGYMH; (SEQ ID NO: 5) VL CDR2 DT SKLA S; (SEQ ID NO: 6) and VL CDR3 FQGS G YP F T; (SEQ ID NO: 7) and wherein at least one of said one or more amino acid changes is in VH CDR2.