Patent ID: 8541476

Claim:
A method of treating a mammal diagnosed with cancer, said method comprising administering to said mammal a therapeutically effective amount of a pharmacological composition comprising a compound of formula (I): wherein: Y is NO 2 , NR 1 3 , CN, CHO, C(O)R 1 or CF 3 ; X is H, F, Cl, Br or I; R is CN, CHO, C(O)R 1 , C(O)NH 2 , C(O)NHR 1 , C(O)NR 1 R 2 , S(O) m R 1 , S(O) 2 NH 2 , S(O) 2 NHR 1 , S(O) 2 NR 1 R 2 , P(O)(OH)R 1 , C(O)OH, or C(O)OR 1 ; R 1 and R 2 each independently is CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH 2 CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , or C(CH 3 ) 3 ; and m is an integer of 0, 1 or 2; or a pharmaceutically acceptable salt, wherein said composition contacts a cancer cell or tumor in said mammal, thereby making said cancer cell or tumor more susceptible to the effects of ionizing radiation, wherein said cancer is at least one selected from the group consisting of glioma, colorectal cancer and non-small cell lung cancer.