Patent ID: 8536147

Claim:
An antisense conjugate, comprising (a) an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, wherein the oligonucleotide contains between 10-20 bases and a targeting sequence of at least 10 contiguous bases complementary to a target sequence containing or within 20 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes acyl carrier protein (acpP), wherein the target sequence is the Burkholderia mallei acpP sequence of SEQ ID NO: 54 or the Burkholderia pseudomallei acpP sequence of SEQ ID NO: 57, and (b) a carrier peptide represented by the formula (RAhxR) 4 or (RFF) 3 , wherein Ahx is aminohexanoic acid.