Patent ID: 8058295

Claim:
A method of treating a subject having a cystic fibrosis transmembrane conductance regulator (CFTR) protein-mediated condition treatable by inhibiting CFTR-mediated ion transport, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (Ib): wherein X 1 is trifluoromethyl; X 2 and X 3 are independently chosen from hydrogen and a halo group; Y 1 , Y 2 and Y 3 are independently chosen from hydrogen, C 1 -C 8 alkyl, C 1 -C 7 alkoxy, carbonate, carbamate, carboxyl, a halo group, a nitro group, an azo group, a hydroxyl group and a mercapto group; or a pharmaceutically acceptable salt thereof, as an individual stereoisomer or a mixture thereof.