Patent ID: 8858999

Claim:
A process for producing functionalized derivatives of hyaluronic acid having a molecular weight in the range of 50,000 to 1,500,000 dalton comprising the following subsequent steps: a) activation of at least one hydroxyl group of hyaluronic acid, in the form of a salt thereof soluble in organic solvents, by reaction of the said hyaluronic acid salt, in a polar aprotic solvent, with a carbonilating agent selected from carbonic phenyl esters and haloformic phenyl esters; b) reaction of the activated hyaluronic acid salt resulting from step a), through a nucleophilic substitution reaction with a compound of the general formula NH2-R, wherein R is selected from the group consisting of NH2, an amino alkyl group, an alkyl or an arylalkyl chain, a polyacrylic chain, a polyoxyethylene chain or a molecule of low molecular weight (as example a drug) or a high molecular weight molecule.