Patent ID: 8044061

Claim:
A compound corresponding in structure to formula (Ia) or a pharmaceutically acceptable salt, diastereomer or enantiomer thereof wherein, R 2 is hydrogen or methyl; R 3 is methyl, propargyl, butynyl, or cyanomethyl; R 4 is imidazol-2-yl or thien-3-yl optionally substituted with one or more substituents selected from halogen, methyl, or methoxy; or R 4 is phenyl which is substituted in meta position to its attachment position to the triple bond with a residue selected from the group consisting of amino, —OR 5 and methyl; and which in para position is unsubstituted or substituted with methoxy, methyl, or fluoro; or R 4 is phenyl that is annelated in 3- and 4-position to a second heterocyclic 5 or 6-membered ring which contains one or more oxygen atoms thus forming a bicyclic ring system, which can be substituted with a methyl, methoxy or hydroxyl group; R 5 is hydrogen or methyl; or R 5 is (C 1 -C 4 )-alkyl substituted in one or more places, in the same way or differently, with methoxy, carboxy, hydroxyl or a phosphate ester thereof, or with —NR 6 R 7 , and R 6 and R 7 are independently hydrogen, or (C 1 -C 3 )-alkyl; or R 6 and R 7 together with the nitrogen atom to which they are attached form a five or six membered ring which may contain one or two additional ring forming heteroatoms selected from N and O, and the five or six membered ring may be unsubstituted or substituted with one or more residues selected from the group consisting of (C 1 -C 3 )-alkyl; hydroxyl(C 1 -C 3 )-alkyl; amino(C 1 -C 3 )-alkyl; (C 1 -C 3 )-alkoxy(C 1 -C 3 )-alkyl; halo(C 1 -C 3 )-alkyl; mono(C 1 -C 2 )-alkylamino(C 1 -C 3 )-alkyl; and di(C 1 -C 2 )-alkylamino(C 1 -C 3 )-alkyl.