Patent ID: 7897776

Claim:
A compound of Formula I or its pharmaceutically acceptable salt, wherein: X and Y are independently selected from —CH 2 — or —CH 2 —CH 2 —; Z is selected from S(O) m or Se(O) m ; m is 0, 1 or 2; R 1 is heteroaryl, optionally substituted by one or more substituents independently selected from the group consisting of halo, alkyl, alkenyl, cycloalkyl, acyl, hydroxy, hydroxyalkyl, heterocyclic, heteroaryl, aryl, amino, aminoalkyl, —NR 5 R 6 , oxo, cyano, carboxy, carboxyalkyl, alkoxycarbonyl, —OR 5 , —C(O)R 5 , —C(O)—NH 2 , —C(O)—N(H)R 5 , —C(O)—N(H)OR 5 , —C(O)—NR 5 R 6 , —NR 6 C(O)R 5 , —NR 6 C(O)NR 5 R 6 , —OC(O)NR 5 R 6 , —NR 6 C(O)OR 5 , —S(O) n —R 5 , —S(O) 2 —NH 2 , —S(O) n —N(H)R 5 and —S(O) 2 —NR 5 R 6 ; n is 0, 1 or 2; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 straight alkyl, and C 1 -C 6 branched alkyl, wherein all may be optionally substituted by one or more selected from the group consisting of halo, hydroxy, heterocyclic, heteroaryl, carboxy, —NR 5 R 6 , alkoxycarbonyl, —NR 6 C(O)R 5 , —NR 6 C(O)NR 5 R 6 , —NR 6 C(O)OR 5 , —OC(O)NR 5 R 6 , —OR 5 , —C(O)R 5 , —S(O) n —R 5 , —C(O)—NR 5 R 6 , and cyano; R 3 and R 4 are independently selected from the group consisting of C 1 -C 6 straight alkyl, C 1 -C 6 branched alkyl, and C 3 -C 8 cyclic alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, C 1 -C 6 straight alkyl, C 1 -C 6 branched alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cyclic alkyl, aryl, heteroaryl, heterocycle, and acyl, wherein all may be optionally substituted by one or more substituents independently selected from the group consisting of halo, alkyl, alkenyl, cycloalkyl, acyl, hydroxy, hydroxyalkyl, heterocyclic, heteroaryl, aryl, amino, aminoalkyl, —NR 7 R 8 , oxo, cyano, carboxy, carboxyalkyl, alkoxycarbonyl, —OR 9 , —C(O)R 9 , —C(O)—NH 2 , —C(O)—N(H)R 7 , —C(O)—NR 7 R 8 , —NR 7 C(O)R 9 , —NR 7 C(O)OR 9 , —S(O) n —R 9 , —S(O) 2 —NH 2 , —S(O) 2 —N(H)R 7 and —S(O) 2 —NR 7 R 8 ; and R 5 and R 6 taken together may form a 4- to 12-membered monocyclic, bicyclic, tricyclic or benzofused ring; R 7 and R 8 are independently selected from the group consisting of alkyl, alkenyl and aryl and taken together may form a 4- to 12-membered monocyclic, bicyclic, tricyclic or benzofused ring; and R 9 is independently selected from the group consisting of C 1 -C 6 straight alkyl, C 1 -C 6 branched alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cyclic alkyl, heterocyclic, heteroaryl and aryl, wherein all may be substituted by one or more substituents independently selected from the group consisting of halo, alkyl, acyl, hydroxy, hydroxyalkyl, heterocyclic, heteroaryl, aryl, amino, aminoalkyl, and carboxy.