Patent ID: 7371381

Claim:
An isolated antibody that immunospecifically binds to an epitope comprising amino acid residues 21 through 27 of SEQ ID NO:150 with a k a of at least 1×10 8 M −1 , wherein the antibody comprises a variable heavy (VH) domain having the amino acid sequence of a VH domain of the murine antibody 5B4, 1G12, 2F8, 1D7, 4B3, 2H9 or 1A1, or the humanized antibody 5B4-v2, 5B4-v4, 5B4-v5, 5B4-v6, 5B4-v7, 5B4-v8, 5B4-v9, 5B4-v10, 5B4-v11, 5B4-v12, or 5B4-v13.