Patent ID: 8227405

Claim:
A peptide selected from the group having the formulae: peptide selected from the group having the formulae: [R 1 -A 0 ,A 1 ,A 2 ,A 6 ,A 8 ,A 9 ,A 10 ,A 11 ,A 12 ,A 13 ,A 15 ,A 17 ,A 19 ,A 20 ,A 21 ,A 22 ,A 23 ,A 27 , A 28 ,A 29 -A 30 ]hGH-RH(1-30)-R 2 wherein: R 1 is Ac, (Ac-Ada), PhAc and PhF 5 Ac, A 0 is Dca, PhAc, PhF 5 Ac, (Dca-Ada), (CH 3 —(CH 2 ) 10 —CO-Ada), (Ac-Ada), (PhAc-Ada), or (PhF 5 Ac-Ada), A 1 is Tyr or Fpa5, A 2 is D-Arg, D-Har, D-Cit, or D-Amp, A 6 is Fpa4, A 8 is (Me-Ala), A 9 is Har, D-Har, D-Arg, Fpa, D-Fpa, His, D-His, Amp, D-Amp, or D-Gup, A 10 is Fpa5, A 11 is His, D-His, Cit, D-Cit, Har, D-Har, AMP, D-AMP, or D-Gup, A 12 is Lys (Me) 2 , Lys(iPr), Orn, D-Orn, Har, D-Har, Cit, D-Cit, Nle, or D-Nle, A 13 is Fpa, or Val, A 15 is His, A 17 is Glu, A 19 is Ala or Abu, A 20 is His, D-His, Har, D-Har, AMP, D-AMP, Cit, or D-Cit, A 21 is Lys, D-Lys, Lys(Me) 2 , Lys(iPr), Orn, D-Orn, Har, D-Har, Cit, or D-Cit, A 22 is Fpa, Leu, Tyr, Ala, or Aib, A 23 is Fpa, Leu, Tyr, Ala, or Aib, A 27 is Nle, Met, Leu, Ala, Abu, α-Apa, α-Ahea, or α-Aoc, A 28 is Arg, D-Arg, Har, D-Har, Ser, Asn, Asp, Ala, Abu, or Cit, A 29 is Arg, D-Arg, Har, D-Har, Cit, D-Cit, or Agm, A 30 is Ada or Agm, R 2 is —NH 2 , or —OH provided that if A 29 is Agm then A 30 and R 2 are absent, and if A 30 is Agm then R 2 is absent, and pharmaceutically acceptable salts thereof.