Patent ID: 8822514

Claim:
A compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein each of B 1 , B 2 , B 3 and B 4 , independently, is CR 3 ; C 1 is CH; C 2 is CH; L 1 is O; L 2 is —(CR 3 R 3 ) n ,C(O)NR 3 , —(CR 3 R 3 ) n NR 3 C(O)—, —(CR 3 R 3 ), n S(O) 2 NR 3 —or —NR 3 S(O) 2 —; R 1 is H or C 1-10 -alkyl; R 2 is H, C 1-10 -alkyl, halo, CN, haloalkyl, NO 2 , NH 2 , —NH—C 1-10 -alkyl, —N-di-C 1-10 -alkyl, OH or —O—C 1-10 -alkyl; each R 3 , independently, is H, C 1-10 -alkyl or halo; R 4 is a phenyl, ring, optionally substituted independently with 1-5 substituents of R 5 or R 6 ; R 5 is a partially or fully saturated or unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic carbocyclic or aryl ring system, wherein each ring of said ring system is optionally substituted independently with 1-3 substituents of R 6 , oxo, NR 6 R 6 , OR 6 , SR 6 , C(O)R 6 , COOR 6 , C(O)NR 6 R 6 , NR 6 C(O)R 6 , NR 6 C(O)NR 6 R 6 , OC(O)NR 6 R 6 , S(O) 2 R 6 , S(O) 2 NR 6 R 6 or NR 6 S(O) 2 R 6 ; each R 6 , independently, is H, oxo, halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic carbocyclic or aryl ring system, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-3 substituents of halo, haloalkyl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, methylamine, dimethylamine, ethylamine, diethylamine, propylamine, isopropylamine, dipropylamine, diisopropylamine, benzyl or phenyl; and n is 0.