Patent ID: 8143270

Claim:
A compound of the following Formula II: wherein: R 2 and R 2 ′ are independently selected from the group consisting of hydrogen, C 1-4 alkyl, hydroxyC 2-4 alkylenyl, and alkoxyC 2-4 alkylenyl; R A1 and R B1 taken together form a fused benzene ring wherein the benzene ring is unsubstituted or substituted by one R 3 group, or substituted by one R 3 group and one R group, or substituted by one or more R groups; or R A1 and R B1 taken together form a fused 5 to 7 membered saturated, carbocyclic ring wherein the ring is unsubstituted or substituted by one or more R groups; R is selected from the group consisting of halogen, hydroxy, alkyl, alkenyl, haloalkyl, alkoxy, alkylthio, and —N(R 9 ) 2 ; R 1 is selected from the group consisting of: hydrogen, alkyl, arylalkylenyl, hydroxyalkyl, dihydroxyalkyl, haloalkyl, —X 1 —Y 1 —R 4 ′, —X 1 —Y 1 —X 1 ′—Y 1 ′—R 4 ′, and —X 1 —R 5 ′; X 1 is alkylene; X 1 ′ is C 1-4 alkylene or phenylene; Y 1 is —N(R 8 )—C(O)—, —N(R 8 )—S(O) 2 —, —N(R 8 )—C(R 6 )—N(R 8 )—, —N(R 8 )—C(R 6 )—N(R 8 )—C(O)—, or —N(R 8 )—C(R 6 )—O—; Y 1 ′ is —S—, —NHC(O)—, —C(O)—O—, or —C(O)—; R 4 ′ is alkyl, aryl, heteroaryl, heterocyclyl, arylalkylenyl, heteroarylalkylenyl, or arylalkenylenyl, wherein alkyl, aryl, heteroaryl, heterocyclyl, or arylalkylenyl is optionally substituted by one or more substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, haloalkoxy, heterocyclyl, cyano, alkoxy, dialkylamino, and, in the case of alkyl or heterocyclyl, oxo; R 5 ′ is R 3 is —Z—R 4 , Z is selected from the group consisting of a bond and —O—; R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo; A is selected from the group consisting of —O—, —C(O)—, —S(O) 0-2 —, and —N(R 4 )—; a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7; R 6 is selected from the group consisting of ═O and ═S; R 8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and arylalkylenyl; and R 9 is selected from the group consisting of hydrogen and alkyl; or a pharmaceutically acceptable salt thereof.