Patent ID: 8460274

Claim:
An implantable drug delivery device, comprising a polyurethane-based polymer having polyether-based polyol segments represented by the formula O—(CH 2 —CH 2 —CH 2 —CH 2 ) x —O— whereby an increase in “x” represents a decrease in Flex Modulus, said polyurethane-based polymer configured to provide a cylindrically shaped reservoir, wherein the reservoir is sealed after being charged with an effective amount of solid formulation comprising an active agent and one or more pharmaceutically acceptable carriers, such that the release of the active agent at a substantially zero order rate in vitro by diffusion through the polyurethane-based polymer generally increases with the selection of the polyurethane-based polymers of decreasing Flex Modulus, wherein the active agent is risperidone, dexamethasone, naltrexone, metolazone, clonidine, or selegiline.