Patent ID: 8188288

Claim:
A compound of formula I wherein R 1 is H, OH, F, Br, or OR 8 , Z is O, R 2 is H, methyl, ethyl or isopropyl, Y is a direct bond or C 1 -C 4 alkyl or C 1 -C 4 alkyloxy, or R 2 , Y and the N to which they are attached form a saturated C 5 -C 8 ring, optionally substituted by R 3 , R 4 and/or R 5 ; W is heterocyclyl or heteroaryl, optionally substituted by R 3 , R 4 and/or R 5 ; R 3 , R 4 , R 5 are independently from each other H, Hal, OH, alkyl, C 1 -C 1 alkyloxy, benzyloxy, phenoxy, phenyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, trifluoromethylsulfanyl, dimethylamino, S(O n (CH 2 ) m CH 3 , C 1 -C 1 alkyloxycarbonyl, C 1 -C 1 alkylcarbonyl or R 6 R 7 NC 1 -C 1 alkyloxy, n is 0-2, m is 1-3, R 6 , R 7 are independently from each other C 1 -C 1 alkyl or form together with the N atom a saturated heterocyclic ring with 4-8 C atoms, R 8 is alkyl, C(O)R 9 , C(O)NH 2 or C(O)NR 9 R 1 °, R 9 is H, C 1 -C 8 alkyl or C 1 -C 8 cycloalkyl, and R 10 is alkyl or R 8 is alkyl, C(O)R 9 , C(O)NH 2 or C(O)NR 9 R 10 , R 9 is H, C 1 -C 8 alkyl or C 1 -C 8 cycloalkyl, and R 10 is alkyl or the group NR 9 R 1 ° in C(O)NR 9 R 1 ° is heterocyclyl, and wherein either R 1 is OH or F, Z is O, and R 2 is H or methyl, or R 1 is OR 8 or a pharmaceutically acceptable salt, hydrate or alcoholate thereof or stereoisomer thereof, or a mixture thereof.