Patent ID: 8759400

Claim:
A composition comprising a selective and synergistic amount of (i) a histone deacetylase inhibitor, or a hydrate, solvate, pharmaceutically acceptable salt thereof, wherein the histone deacetylase inhibitor is a compound of formula (A) or a hydrate, solvate, or pharmaceutically acceptable salt thereof, wherein R is alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl, preferably cycloalkyl, aryl, heteroaryl or heterocyclyl, any of which maybe optionally substituted; x is an integer from 0 to 5, wherein the chain of length x is optionally substituted and wherein one carbon atom of the chain of length x is optionally replaced with a heteroatom; n is an integer from 0 to 2; and Y is H; with the provisos that when x is 4, n is not 2, and when x is 3, n is not 3; (ii) an antifungal effective amount of an antifungal agent, wherein the antifungal agent is an azole; and (iii) a pharmaceutically acceptable carrier, wherein the selective and synergistic amount of a histone deacetylase inhibitor is not toxic to mammalian cells.