Patent ID: 7759344

Claim:
A compound of the following Formula I, II or III. enantiomers, diastereomers, and salts thereof wherein R 1 is an aryl ring system or a 5-14-membered nitrogen containing heteroaryl or heterocyclyl ring system; any of which may be optionally independently substituted with 1 to 4 Z groups; R 2 is R 3 is hydrogen or alkyl optionally substituted with one or more Z groups; R b is independently selected at each occurrence from a) H, or b) C 1-6 alkyl, C 3-6 cycloalkyl, C 6-10 aryl, C 6-10 aryl-C 1-3 alkyl, C 5-10 heteroaryl, C 5-10 heteroaryl-C 1-3 alkyl, 5-6 membered heterocyclyl or 5-6-membered heterocyclyl-C 1-3 alkyl, any of which may be optionally substituted with one or more Z groups; R c is selected from a) H, halo, hydroxy or b) C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkyoxyC 1-6 alkyl, hydroxy-C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl-C 1-3 alkyl, C 5-10 heteroaryl, C 5-10 heteroaryl-C 1-3 alkyl, 5-6 membered heterocyclyl, 5-6-membered heterocyclyl-C 1-3 alkyl, R d R e N— or R d R e N—C 1-3 alkyl, any of which may be optionally substituted with one or more Z groups; R d is selected from a) H, or b) C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-6 alkyl, C 1-6 alkyoxyC 1-6 alkyl, hydroxy-C 1-6 alkyl, C 6-10 aryl-C 1-3 alkyl, C 5-10 heteroaryl-C 1-3 alkyl, or 5-6-membered heterocyclyl-C 1-3 alkyl, any of which may be optionally substituted with one or more Z groups; R e is selected from a) H or b) C 1-6 alkyl, C 6-10 aryl-C 1-3 alkyl, 5-6 membered heterocyclyl-C 1-2 -alkyl, 5-6-membered heterocyclyl; C 6-10 aryl, C 5-10 heteroaryl, or C 5-10 heteroaryl-C 1-3 alkyl, any of which may be optionally substituted with one or more Z groups; or when R d and R e are bonded to the same nitrogen atom, they may optionally combine to form a heterocyclyl ring, Z is an optional substituent independently selected at each occurrence from a*) halo, nitrile, hydroxy, alkoxy, aryloxy, heteroaryloxy; heterocylyloxy, cycloalkyloxy, aralkyloxy, heteraralkyloxy, heterocyclylalkoxy, cycloalkylalkoxy, —NR b R b , —NR b —C(═O)R b , —NR b —C(═O)OR b , —NR b —C(═O)—NR b R b , C(═O)—NR b R b , —C(═O)OR b ; —S(O 2 )—NR b R b , —NR b —(SO 2 )R b , —S(O 2 )R b , and —S(O)R b ; or b*) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl, any of which may be optionally substituted with one or more of the substituents listed in the above section a*; and n is an integer from zero to three.