Patent ID: 7674818

Claim:
A compound of formula I: wherein: R 1 is benzo[1,3]dioxol-5yl-methyl, cycloalkylalkyl wherein the alkyl chain is C 1 -C 3 , benzyl, CH 2 -1-naphthyl, CH 2 -2-naphthyl, CH 2 CH 2 -phenyl, or CH 2 CH 2 naphthyl, wherein the cycloalkyl, phenyl, benzyl, and naphthyl, groups are optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, C 1 -C 3 perfluoroalkoxy, C 1 -C 3 alkylthio, C 1 -C 3 perfluoroalkylthio, —OCHF 2 , —CN, —C(O)CH 3 , —CO 2 R 7 , —C(O)NH 2 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 2 is hydrogen, C 1 -C 6 alkyl, —CH 2 —C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl, wherein the alkyl and cycloalkyl groups are optionally substituted by halogen, —CN, C 1 -C 6 alkoxy, —COOH, —CH 2 CO 2 H, —C(O)CH 3 , —CO 2 R 7 , —C(O)NH 2 —, —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; R 3 is the moiety X—R 6 ; wherein: X is O, S, or NH; R 6 is C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 6 cycloalkyl, phenyl, wherein the alkenyl, alkynyl, cycloalkyl and phenyl groups are optionally substituted by from 1 to 3 groups selected from halogen, C 1 -C 3 alkyl, C 1 -C 3 perfluoroalkyl, —O—C 1 -C 3 perfluoroalkyl, —S—C 1 -C 3 perfluoroalkyl, C 1 -C 3 alkoxy, —OCHF 2 , —CN, —C(O)CH 3 , —CO 2 R 7 , —S(O) 2 CH 3 , —OH, —NH 2 , or —NO 2 ; and R 7 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, —CH 2 -C 3 -C 6 cycloalkyl, or aryl-alkyl wherein the alkyl chain is C 1 -C 8 ; or a pharmaceutically acceptable salt or ester form thereof.