Patent ID: 7074819

Claim:
A thiobenzopyran derivative represented by the following formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X represents S, R 1 represents hydrogen, hydroxy, or â€”OR 6 (wherein R 6 represents acyl or alkyl), R 2 represents phenyl which is optionally substituted by one or more substituents selected from a group consisting of hydroxy, lower alkyl, halogen, nitro, hydroxymethyl, carboxy, alkoxycarbonyl, â€”OR 6 (wherein R 6 represents acyl or alkyl) and amino which is optionally substituted by one or two lower alkyl; or represents 5- or 6-membered unsaturated heterocycle containing nitrogen, oxygen or sulfur as the hetero atom, R 3 represents hydrogen or lower alkyl, provided that R 3 , does not exist when is a double bond (wherein represents a single bond or a double bond), R 4 represents hydrogen or lower alkyl, A represents hydrogen; hydroxyalkyl; carboxyalkyl; carboxyvinylphenyl; pyrrole substituted by carboxyvinylbenzyl; or represents a group selected from the following formulae (a) to (l); in the above formulae (a) to (l) m 1 , to m 3 independently of one another represent an integer of 0 to 15, n 1 , to n 2 independently of one another represent an integer of 0, 1 or 2, R 5 represents cyano; alkyl; halogenoalkyl; alkoxy; hydroxy; carboxy; alkoxycarbonyl; carbamoyl; monoalkylamino; phenyl which is optionally substituted by one or more substituents selected from a group consisting of straight-chain or branched alkyl, carboxy and cyano; piperidinyl which is optionally substituted by one or more substituents selected from a group consisting of carboxy, alkyl and alkoxycarbonyl; cyclohexyl which is optionally substituted by carboxy; imidazolyl; dialkylamino; or piperidinyl oxide, D 1 and D 2 independently of one another represent a direct bond, or a group selected from the following: wherein m, m 1 and m 2 independently of one another represent an integer of 0 to 15, and R 5 is defined as above.