Patent ID: 8114584

Claim:
A method of forming an array of polymers on a surface of a substrate, said method comprising: providing a substrate having a first layer on a solid support, said first layer including one or more dielectric coatings, wherein at least one coating of said one or more dielectric coatings possess antireflective properties, and wherein said one or more dielectric coatings are coated onto a top surface of said solid support; derivatizing said first layer by contacting said first layer with a silanation reagent, wherein said derivatizing creates a second layer disposed on said first layer, wherein said second layer includes functional groups protected with a photolabile protecting group, and wherein said photolabile protecting groups are designed to be removed with illumination of light within a wavelength region that is photolytic to said photolabile protecting groups; activating first selected regions on said top surface of said substrate by removing said protecting groups from said functional groups in said first selected regions; coupling a first monomer to said functional groups in said first selected regions; activating second selected regions on said surface of said substrate by removing said protecting groups from said functional groups in said second selected regions; coupling a second monomer to said functional groups in said second selected regions; and repeating said activating and coupling steps to form a plurality of different polymer sequences, each of said different polymer sequences being coupled to said surface of said substrate in a different known location.