Patent ID: 7375102

Claim:
A compound having the formula (I): or a pharmaceutically acceptable salt thereof, wherein Q is a member selected from the group consisting of —C(O)—, —CH 2 CO—, —CH 2 SO— and —CH 2 SO 2 —; L is a bond or (C 1 -C 5 )alkylene; A 1 , A 2 and A 3 are independently selected from the group consisting of C(R′)(R″) and C(O); A 4 is C(R′)(R″) or N(R′″); each R′ and R″ is independently selected from the group consisting of hydrogen, halogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, fluoro(C 1 -C 4 )alkyl, aryl, heteroaryl, aryl(C 1 -C 8 )alkyl and heteroaryl(C 1 -C 8 )alkyl, optionally, R′ and R″ groups on adjacent carbon atoms may be combined to form a 5- or 6-membered fused ring, and R′ and R″ groups attached to the same carbon atom may be combined to form a 3-8 membered spirocyclic ring; R′″ is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl and (C 2 -C 8 )heteroalkyl; R 1 is heteroaryl or aryl; R 2 is selected from the group consisting of hydrogen, halogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )heteroalkyl, hetero(C 1 -C 10 )cycloalkyl, (C 1 -C 10 )alkylaryl and (C 2 -C 10 )heteroalkylaryl, optionally R 2 may be combined with L to form a 5-, 6-, 7- or 8-membered ring containing from 1 to 3 heteroatoms selected from the group consisting of N, O and S; R 3 is absent or is a member selected from the group consisting of —H, —CHR 6 R 7 , S(O) m R 5 , —S(O) m N(R 8 )R 9 , —S(O) m N(R 8 )CH 2 R 6 , —N(R 8 )SO 2 R 5 , —N(R 8 )CH 2 R 10 , wherein R 5 is selected from the group consisting of (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, aryl and heteroaryl; R 6 and R 7 independently are hydrogen, (C 1 -C 8 )alkyl or (C 2 -C 8 )heteroalkyl, R 8 is hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )heteroalkyl, heteroaryl or aryl, R 9 is (C 1 -C 8 )alkyl; R 10 is aryl, Z is CH or N, X is a bond, (C 1 -C 6 )alkylene or (C 1 -C 6 )heteroalkylene, Y is (C 1 -C 6 )alkylene; the subscript m is 0, 1 or 2; or optionally, R 3 may be combined with R 2 to form a 4-, 5-, 6-, 7- or 8-membered ring containing from 1 to 3 heteroatoms selected from the group consisting of N, O and S; and R 4 is a member selected from the group consisting of (C 1 -C 20 )alkyl, (C 2 -C 20 )heteroalkyl, heteroaryl, aryl, heteroaryl(C 1 -C 6 )alkyl, heteroaryl(C 2 -C 6 )heteroalkyl, aryl(C 1 -C 6 )alkyl and aryl(C 2 -C 6 )heteroalkyl.