Patent ID: 7351874

Claim:
A method for screening a candidate agent for an ability to modulate a cannabinoid-mediated behavior in a transgenic mouse comprising: (a) administering to a first transgenic mouse the candidate agent, and (b) comparing the cannabinoid-mediated behavior of the first transgenic mouse to the cannabinoid-mediated behavior of a second transgenic mouse not administered the candidate agent; wherein a difference in the cannabinoid-mediated behavior in the first transgenic mouse administered the candidate agent compared to the second transgenic mouse not administered the candidate agent indicates that the candidate agent modifies the cannabinoid-mediated behavior; and wherein the transgenic mouse has a homozygous transgene which (i) disrupts or interferes with expression of an endogenous fatty acid amide hydrolase (FAAH) gene, and (ii) is chromosomally integrated into germ cells of the mouse.