Patent ID: 7855294

Claim:
A compound of the formula I: wherein: A 1 , A 2 , A 3 and A 4 each independently represent —C(R 5 )— or —N—, provided that only one of A 1 , A 2 , A 3 and A 4 is —N—; A 5 , A 6 , A 7 and A 8 each independently represent —C(R 6 )— or —N—, provided that only one of A 5 , A 6 , A 7 and A 8 is —N—; R 1 and R 1 ′ are independently selected from a hydrogen atom, a hydroxyl group, a C 1-6 alkyl group, a C 1-6 alkyloxy group, a C 1-6 alkylsulfonylamino group, and a C 1-6 alkylcarbonylamino group, or R 1 and R 1 ′ together form an oxo group or a C 1-3 alkyleneketal group; R 2 represents a hydrogen atom; R 2 ′ represents a hydrogen atom, or R 2 ′ and R 2 together form a C 1-3 alkylene group; R 3 is selected from a hydrogen atom, a hydroxyl group, a halogen atom, a C 1-6 alkyloxy group, a C 1-6 alkyl group, a hydroxy-C 1-6 alkyl group, a halo-C 1-6 alkyl group, a C 1-6 alkylsulfonylamino group, a C 1-6 alkylsulfonyl C 1-6 alkylamino group, a C 1-6 alkyloxy carbonylamino C 1-6 alkyl group and a dimethylsulfamoylaminomethyl group; R 3 ′ is selected from a hydrogen atom, a hydroxyl group, a halogen atom, a C 1-6 alkyloxy group, a C 1-6 alkyl group, a hydroxy-C 1-6 alkyl group, a halo-C 1-6 alkyl group, a C 1-6 alkylsulfonylamino group, a C 1-6 alkylsulfonyl C 1-6 alkylamino group, a C 1-6 alkyloxy carbonylamino C 1-6 alkyl group and a dimethylsulfamoylaminomethyl group; R 4 is selected from a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a cyano group, a formyl group and a halogeno-C 1-6 alkyl group; or when Z is —C(R 7 )—, then R 4 and R 7 together form a —CH 2 —O—, —CH(CH 3 )—O—, —C(CH 3 ) 2 —O— or —N(CH 3 )—CH 2 — group; R 5 is selected from a hydrogen atom, a hydroxyl group, a fluorine atom, a chlorine atom, a C 1-6 alkyl group, a C 1-6 alkylamino group, a C 1-6 alkylcarbonyl group, a C 1-6 alkylcarbonylamino group, a C 1-6 alkylcarbonyl-(C 1-6 )alkylamino group, and a cyano group; R 6 is selected from a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a halogeno-C 1-6 alkyl group, a C 1-6 alkyloxy-C 1-6 alkyl group, a C 1-6 alkylcarbonyl group, a cyano group, and a formyl group; R 7 is selected from a hydrogen atom, a halogen atom and a C 1-6 alkyl group; or R 7 and R 4 together form a —CH 2 —O—, —CH(CH 3 )—O—, —C(CH 3 ) 2 —O— or —N(CH 3 )—CH 2 — group; Ra is selected from a hydrogen atom, a C 1-6 alkyl group, a C 1-6 alkyloxycarbonyl group, a carbamoyl group, a (C 1-6 alkyl)carbamoyl group, a di(C 1-6 alkyl)carbamoyl group, a C 1-6 alkylsulfonyl group, a pyrazolyl group, a triazolyl group, and an oxazolyl group; X represents —CH 2 — or —CH(OH)—; Y represents —CH 2 — or —N(Ra)—; Z represents —C(R 7 )— or —N—; n indicates an integer which is 0; or a pharmaceutically acceptable salt thereof.