Patent ID: 7265120

Claim:
A pyrazine compound shown by the following formula (I): wherein R 1 is hydrogen, lower alkyl or substituted lower alkyl X is hydrogen, halogen, hydroxy, mercapto, cyano or acyl, or lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, lower alkoxy, substituted lower alkoxy, cyclo(lower)alkoxy, lower alkylthio, aryloxy, arylthio, amino, substituted amino, aryl, substituted aryl, heterocyclic group, substituted heterocyclic group or heterocyclyloxy; Y is hydrogen, halogen, hydroxy, mercapto, cyano, acyl or lower alkyl, substituted lower alkyl, lower alkoxy, substituted lower alkoxy, lower alkylthio, amino, substituted amino, aryl, substituted aryl, or heteroaryl; and Z is aryl, substituted aryl, or heteroaryl; or a salt thereof wherein substituted lower alkyl is substituted with a substituent selected from the group consisting of halogen, lower alkenyl, lower alkoxy, hydroxy, cyclo(lower)alkyl, amino, substituted amino, acylamino, aryl, substituted aryl, heterocyclic group and acyl; wherein substituted lower alkenyl is substituted with a substituent selected from the group consisting of lower alkoxy, hydroxy, cyclo(lower)alkyl, amino, aryl, heterocyclic group and acyl; wherein substituted lower alkynyl is substituted with a substituent selected from the group consisting of lower alkoxy, hydroxy, cyclo(lower)alkyl, amino, aryl, heterocyclic group and acyl; wherein substituted lower alkoxy is substituted with a substituent selected from the group consisting of hydroxy, halogen, cyclo(lower)alkyl, lower alkoxy, amino, substituted amino, aryl, substituted aryl, heterocyclic group and acyl; wherein substituted amino is substituted with a substituent selected from the group consisting of lower alkyl, acyl, sulfonyl, methylene, (dimethylamino)methylene and dimethylsulfanylidene; wherein substituted aryl is substituted with a substituent selected from the group consisting of lower alkyl, lower alkoxy, hydroxyl and halogen; and wherein substituted heterocyclic group is substituted with a substituent selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, oxo, halogen, benzyl, amino, substituted amino and aryl.