Patent ID: 7071207

Claim:
A compound of Formula (I) wherein R 1 is phenyl optionally substituted with one or more halogen, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, (C 1 –C 6 )alkylthio, trifluoromethyl, trifluoromethoxy, carboxyl, amino, cyano, nitro, (C 1 –C 6 )alkyl-carbonyl-amino, (C 1 –C 6 )alkyl-amino-carbonyl-amino, or phenyl optionally substituted with one or more halogen; R 2 is a hydrogen, halogen, (C 1 –C 9 )alkyl optionally substituted with (C 1 –C 6 )alkoxy, trifluoromethyl, or with one or more fluorine, phenyl optionally substituted with one or more halogen, (C 1 –C 6 )alkyl, (C 2 –C 8 )alkenyl, (C 2 –C 8 )alkynyl, (C 1 –C 6 )alkoxy, (C 1 –C 6 )alkyl-thio, trifluoromethyl, trifluoromethoxy, carboxyl, amino, cyano, nitro, (C 1 –C 6 )alkyl-carbonyl-amino, (C 1 –C 6 )alkyl-amino-carbonyl-amino, or phenyl, or a 5- to 10-membered aromatic monocyclic or bicyclic heterocyclic radical optionally substituted with one or more halogen, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, trifluoromethyl, trifluoromethoxy, cyano, or nitro; R 3 is hydrogen, (C 1 –C 6 )alkyl, or benzyl; X is —C(═O)—; R 4 is hydrogen, (C 1 –C 9 )alkyl optionally substituted with one or more hydroxy, benzyloxy, (C 1 –C 6 )alkoxy, trifluoromethyl, cyano, or fluorine, benzyl or phenyl, optionally substituted on the phenyl ring with one or more (C 1 –C 6 )alkyl, hydroxy, (C 1 –C 6 )alkoxy, trifluoromethyl, cyano, nitro, or halogen, piperidin-4-yl, piperidin-3-yl, or pyrrolidin-3-yl, each of which may be optionally substituted on the nitrogen atom of the piperidine or pyrrolidine ring with (C 1 –C 6 )alkyl, (C 1 –C 6 )hydroxyalkyl, benzyl, or phenyl, in which the benzyl or phenyl group may optionally be substituted on the phenyl ring with one or more halogen, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, or trifluoromethyl, —NR 5 R 6 in which R 5 and R 6 , taken together with the nitrogen atom to which they are attached, form a 5- to 10-membered saturated or unsaturated heterocyclic radical which is optionally substituted with one or more (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, hydroxy-substituted (C 1 –C 3 )alkyl, (C 1 –C 3 )alkoxy-substituted (C 1 –C 3 )alkyl, benzyl, phenyl, hydroxy, or fluorine, or a 5- to 10-membered aromatic monocyclic or bicyclic heterocyclic radical optionally substituted with one or more halogen, (C 1 –C 6 )alkyl, (C 1 –C 6 )alkoxy, trifluoromethyl, cyano, or nitro; and pharmaceutical salts and esters thereof.