Patent ID: 8552009

Claim:
A compound of Formula I or a pharmaceutically acceptable salt thereof: wherein: Ar and Ar′ each independently represent a phenyl ring; G 1 and G 2 together with the carbons to which they are attached form a [4,5-d]pyrimidyl ring fused to the pyrimidinone ring; L is —CH═CH—; Ar is optionally substituted with one or more substituents selected from the group consisting of: alkyl, halogenated alkyl, alkenyl, alkynyl, lower cycloalkyl, halogen, oxo, thioxo, formyl, acyl, hydroxy, alkoxy, acyloxy, amino, acylamino, amido, alkylsulfonyl, sulfamoyl, alkylsulfonamido, cyano, nitro, alkylthio, azido, —NHSO 2 NH 2 , and —NHSO 2 CH 3 ; Ar′ is optionally substituted with one or more substituents selected from the group consisting of: alkyl, halogenated alkyl, alkenyl, alkynyl, lower cycloalkyl, halogen, oxo, thioxo, formyl, acyl, hydroxy, alkoxy, acyloxy, amino, acylamino, amido, alkylsulfonyl, sulfamoyl, alkylsulfonamido, cyano, nitro, alkylthio, —NHSO 2 NH 2 , —OCH 2 CH 2 NR 7 , and azido, wherein optionally two adjacent substituents together represent —NHSO 2 NH— or —NHC(O)NH— forming a heterocycle with the carbons to which they are attached; and R 7 is lower alkyl; and said compound inhibits TRPV3 with an IC 50 of 10 micromolar or less.