Patent ID: 7446122

Claim:
A compound of Formula I: wherein: (a) X is C, S or O; (b) R 1 is hydrogen; halogen; —OH; —SH; —CN; —NO 2 ; or an unsubstituted or substituted moiety selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl, wherein the substituted groups are substituted with one, two or three suitable substituents each independently selected from the group consisting of: halogens, —CN, —NO 2 , —SH, —OH, unsubstituted alkyl, unsubstituted alkenyl, unsubstituted heteroalkyl, unsubstituted haloalkyl, unsubstituted alkynyl, unsubstituted aryl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted heteroaryl, and —(CH 2 ) z CN where z is an integer from 0 to 6; (c) R 2 , R 3 , R 4 and R 5 are each independently hydrogen; halogen; —OH; —SH; —CN; —NO 2 ; or an unsubstituted or substituted moiety selected from lower alkyl, lower alkynyl, lower alkenyl, alkoxy, haloalkyl, aryl, and heteroaryl; (d) R 6 , R 7 , R 8 and R 9 are each independently hydrogen; halogen; —OH; —SH; —CN; —NO 2 ; or an unsubstituted or substituted moiety selected from alkyl, alkenyl, alkynyl, alkoxy, allyloxy, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein at least one of R 6 , R 7 , R 8 and R 9 is an unsubstituted or substituted moiety selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, alkenyl, and alkynyl; (e) R 10 is hydrogen; or an unsubstituted lower alkyl; (f) Y is an unsubstituted or substituted moiety selected from alkyl, alkenyl, and alkynyl; wherein the substituted moiety is substituted with one, two or three substitutents each independently selected from halogen; —OH; —SH; —CN; —NO 2 ; unsubstituted alkyls, unsubstituted haloalkyls, unsubstituted heteroalkyls, unsubstituted alkenyls, unsubstituted alkynyls, unsubstituted aryls, unsubstituted cycloalkyls, unsubstituted heterocycloalkyls, and unsubstituted heteroaryls; and (g) Z is a moiety selected from —OH, —SH, —OC(O)NH 2 , —SO 2 H, —SO 2 NH 2 , —SO 2 OH, —S(O)H, —NH 2 , —NHC(O)H, C(O)NH 2 , unsubstituted or substituted with one or two suitable substituents selected from the group consisting of alkyl, haloalkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl each independently substituted with one, two or three suitable substituents; wherein R 1 and Y may cyclize to form an unsubstituted or substituted cycloalkyl group or an unsubstituted or substituted heterocycloalkyl group; or a pharmaceutically acceptable salt thereof.