Patent ID: 7947694

Claim:
A compound of formula (I), a N-oxide, an addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein X 1 and X 2 are each independently N or CH with the exception that X i and X 2 can not be both N; n is an integer with value 0 or 1 and when n is 0 then a direct bond is intended; t is an integer with value 0 or 1 and when t is 0 then a direct bond is intended; ring B represents phenyl, cyclopentyl, cyclohexyl, norbornyl or L is a direct bond, —(CH 2 ) r —NR 7 —(CH 2 ) s —, —(CR 8 2 ) r —O—(CH 2 ) s —, —C(═O)—, —(CH 2 ) r —O—C(═O)—, —(CH 2 ) r —NR 7 —C(═O)—, —S(═O) 2 —, —(CH 2 ) r —NH—S(═O) 2 —, or —C 1-4 alkyl-; wherein each —(CH 2 ) r — moiety is linked to R 3 ; each s is an integer with value 0 or 1 and when s is 0 then a direct bond is intended; each r is an integer with value 0, 1, 2 or 3 and when r is 0 then a direct bond is intended; each R 7 is hydrogen, C 1-6 alkyl or C 1-4 alkyloxycarbonyl; each R 8 is independently hydrogen, hydroxy or C 1-6 alkyl; or two R 8 together can form a bivalent radical of formula —CH 2 —CH 2 —; R 1 , R 2 and R 5 are each independently hydrogen, hydroxy or C 1-6 alkyl; R 3 is hydroxy, C 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyloxy, —NR 9 R 10 , —S(═O) 2 —NR 9 R 10 ; or a ring system selected from pyridinyl, triazolyl, or wherein each pyridinyl, triazolyl, or is optionally substituted with one substituent selected from hydroxy, C 1-6 alkyl, hydroxyC 1-6 alkyl, hydroxycyclopropylC 1-6 alkyl, hydroxyC 1-6 alkylcarbonyl, hydroxycyclopropylcarbonyl, hydroxyC 1-6 alkyloxy, C 1-6 alkyloxy, hydroxyC 1-6 alkyloxyC 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-4 alkyloxycarbonyl, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylcarbonyl, C 1-6 alkyloxyC 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyloxyC 1-6 alkyl, pyridinyl, —NR 9 R 10 , or —S(═O) 2 —NR 9 R 10 ; wherein each R 9 and R 10 independently represent hydrogen, C 1-6 alkyl, hydroxyC 1-6 alkyl, hydroxycyclopropylC 1-6 alkyl, C 1-6 alkyloxycarbonyl or C 1-6 alkyloxyC 1-6 alkyl; R 4 is hydrogen or halo; or R 4 together with -L-R 3 — can form a bivalent radical of formula —NH—CH═CH—; and R 6 is hydrogen, C 1-6 alkyl or C 1-4 -alkyloxycarbonyl.