Patent ID: 6919353

Claim:
A compound represented by (I): or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, pyridinone, pyridyl, or pyridyl N-oxide, optionally substituted with 1-5 independent —C 1-6 alkyl, —OH, —CN, halogen, —CF 3 , —(C 0-6 alkyl)-SO n —(C 1-6 alkyl), —(C 0-6 alkyl)-SO n —NH—(C 1-6 alkyl) or 5-membered heteroaryl ring containing 1-4 heteroatoms independently selected from O, S or N, wherein the 5-membered-ring is optionally substituted with C 1-6 alkyl, and the alkyl group- is optionally substituted with 1-3 independent —OH, —CN, halogen, or —CF 3 ; R 1 is hydrogen, halogen; or a —C 1-6 alkyl, -cycloC 3-6 alkyl, —C 1-6 alkenyl, —C 0-4 alkyl-C(O)—C 0-4 alkyl, —C 1-6 alkoxy, aryl, heteroaryl, —CN, -heterocycloC 3-6 alkyl, -amino, —C 1-6 alkylamino, —(C 1-6 alkyl)(C 1-6 alkyl)amino, —C 1-6 alkyl(oxy)C 1-6 alkyl, —C(O)NH(aryl), —C(O)NH(heteroaryl), —SO n NH(aryl), —SO n NH(heteroaryl), —SO n NH(C 1-6 alkyl), —C(O)N(C 0-6 alkyl)(C 0-6 alkyl), —NH—SO n —(C 1-6 alkyl), -carbamoyl, —(C 1-6 alkyl-O—C(CN)-dialkylamino, or —C 0-6 alkyl)SO n —C 1-6 alkyl) group, wherein any of the groups is optionally substituted with 1-5 substituents; wherein each substituent is independently a halogen, —OH, —CN, —C 1 -C 6 alkyl, —C(O)(heterocycloC 3-6 alkyl), —C(O)—O—(C 0-6 alkyl), —C(O)—O-aryl, alkoxy, cycloalkyloxy, acyl, acyloxy, -cycloC 3-6 alkyl, heterocycloC 3-6 alkyl, aryl, heteroaryl, pyridyl N-oxide, carbonyl, carbamoyl, or —SO n —(C 1-6 alkyl); R 2 , R 3 , R 6 , and R 7 are each independently hydrogen, halogen, hydroxyl, —C 1-6 alkyl, or —C 1-6 alkoxy, wherein the alkyl and alkoxy are optionally substituted with 1-3 independently halogen or OH; R 4 is hydrogen, halogen, —CN, phenyl, oxadiazolyl, or —C(O)—O—C 0-6 alkyl, wherein the phenyl, oxadiazolyl, or —C(O)—O—C 0-6 alkyl is optionally substituted with 1-3 independent halogen, CN, CF3, —SO n —C 1-6 alkyl, or C 1-6 alkyl substituents, and the alkyl group is optionally substituted with OH R5 is hydrogen, hydroxyl, —CN; or a —C 1-6 alkyl, —C(O)C 1-6 alkyl, —C(O)-aryl, —C(O)-pyridyl, —C(O)—O—C 0-6 alkyl, —C(O)—C 3-7 cycloalkyl, —C 1-6 alkyl-C 3-7 cycloalkyl, —C 1-6 alkyl(C 3-7 cycloalkyl) 2 , —C 1-6 alkyl-aryl, —C(O)—N(C 0-6 alkyl) 2 , —SO n aryl, —SO n —C 1-6 alkyl, —SO n —C 3-7 cycloalkyl, —SO n —N(C 0-6 alkyl) 2 , —P(O)(C 1-6 alkyl) 2 , —P(O)(C 1-6 alkoxy) 2 , phenyl, pyridyl, —SO n imidazolyl, —SO n thiazolyl, 5-membered heteroaryl ring containing 1-4 heteroatoms independently selected from O, S or N or oxoisoxaphosphinanyl group, any of which group optionally substituted with 1-6 independent halogen, hydroxyl, —CN, —CF 3 , —C 1-6 alkyl, —SO n —C 1-6 alkyl, —C(O)—O—C 0-6 alkyl, or hydroxyC 1-6 alkyl substituents; or R 5 and R 6 form ═O; or R 6 and R 3 form —CH 2 — or —O—; and n is 0, 1, or 2.