Patent ID: 8753683

Claim:
A solid pharmaceutical composition comprising (A) a water-soluble bioactive material which has a low bioavailability in the gastrointestinal tract of an animal and is present in the composition only in the form of solid particles, (B) an encapsulating material in which the solid particles of the bioactive material are dispersed and encapsulated and which is present in the composition in the form of a continuous solid phase, wherein the encapsulating material comprises about 5 to about 80 wt. % of an absorption enhancer and about 10 to about 50 wt. % of a block copolymer surfactant, (C) about 0.01 to about 20 wt. % of another surfactant, and (D) about 0.1 to about 50 wt. % of a biocompatible oil, wherein the solid particles of the bioactive material are dispersed uniformly in the encapsulating material of the composition; the solid particles of the bioactive material and the encapsulating material are a solid at room temperature; the melting point of the encapsulating material is lower than the melting point of the bioactive material; and wherein the composition is stable.