Patent ID: 7390801

Claim:
A compound of Formula I: wherein: R 1 is C 1 -C 6 alkyl; C 2 -C 6 alkenyl optionally substituted with phenyl; C 3 -C 6 cycloalkyl; adamantyl; C 1 -C 6 alkyl substituted with 1 to 3 substituents selected from the group consisting of halo, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl, benzoyl optionally substituted C 1 -C 6 alkoxy, benzylthio, phenoxy, phenyl, phenyl substituted with halo, C 1 -C 6 alkoxy, or C 1 -C 6 alkyl, 3,4-methylenedioxyphenyl, and thienyl; C 1 -C 6 alkoxy; C 1 -C 6 alkylthio; phenylthio; phenoxy optionally substituted in the phenyl ring one or two times with a substituents selected from the group consisting of halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy, and hydroxymethyl; pentafluorophenoxy; aryl selected from phenyl, naphthyl, and phenyl substituted with 1 to 3 substituents selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo, nitro, trihalomethyl, hydroxy, phenyl, and phenoxy; heteroaryl selected from the group consisting of thienyl, 3,4-methylenedioxyphenyl, benzothienyl, indolyl, and tetrazolyl optionally substituted with phenyl; or pyrrolidin-1-yl; R 2 is C 1 -C 6 alkyl; phenyl; or thienyl; T is O, S, or a bond covalently connecting R 1 to —CX′X″—, provided that when T is O or S then both X′ and X″ are hydrogen; X′ and X″ are independently hydrogen, hydroxy, or fluoro; or X′ and X″ taken together with the carbon to which they are attached form a carbonyl; The cyclic group defined by W together with —C(H) p C(═X)— forms a benzodiazepinone optionally substituted in the phenyl ring with a group selected from halo and nitro and optionally further substituted with 1 to 3 substituents selected from the group consisting of C 1 -C 6 alkyl; C 1 -C 6 alkyl substituted with 1 to 3 substituents selected from the group consisting of halo, C 3 -C 6 cycloalkyl, phenyl optionally substituted with C 1 -C 6 alkyl or phenyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyl)—C(O)—, benzoyl, —C(O)—O—(C 1 -C 6 alkyl), phenoxy, tetrahydrofuryl, phthalimid-1-yl, 1,2-ethylenedioxyphenyl, indolin-2-on-1-yl, pyridinyl, benzofuryl, benzothienyl optionally substituted with halo, quinolinyl optionally substituted with trifluoromethyl, and isoxazolyl optionally substituted one or two times with C 1 -C 6 alkyl; oxo; C 3 -C 6 cycloalkyl; phenyl; phenyl substituted with halo; pyridinyl; thiazolyl; thienyl; and piperidin-1-yl.