Patent ID: 8883497

Claim:
A method for generating human myeloid-derived suppressor cells (MDSC) from a source of myeloid lineage cells, wherein said induced MDSC have a phenotype selected from the group consisting of CD33 + CD11b − and CD33 − CD11b + , comprising: (a) contacting the source of myeloid lineage cells with a tumor sample under conditions sufficient to induce MDSC; wherein the tumor sample for CD33 + CD11b − is isolated from a cancer type selected from the group of thyroid, brain, melanoma, cervical/endometrial, ovarian, bladder, non-small cell lung cancer, small cell lung cancer, liver, renal, prostate, gastric, colorectal, pancreatic, wherein the tumor sample for CD33 − CD11b + is isolated from a cancer type selected from breast, non-small cell lung cancer and glioma; and, (b) isolating the induced MDSC.