Patent ID: 8852240

Claim:
A method for augmenting bone in a subject in need thereof, said method comprising: (a) mechanically inducing an increase in osteoblast activity within said subject; (b) installing within an interior portion of a bone within said subject where the increase in osteoblast activity has been induced a sufficient amount of a biocompatible material to form a scaffold within said bone interior, said scaffold serving as a support for formation of new bone within said interior portion; and (c) separately administering to said subject, at a location other than into the bone, a sufficient amount of at least one bone augmentation agent to elevate blood concentration of at least one bone anabolic agent in said subject, wherein said bone augmentation agent is systematically administered at the location other than into the bone by a method selected from the group consisting of by injection, intravenously, peroral, transdermally, trans-nasally and transrectally, and wherein the elevation in blood concentration of the anabolic agent in said subject and the increase in osteoblast activity therein at least partially overlap in time.