Patent ID: 7001916

Claim:
An epothilone compound of formula I, in which R 4 means hydrogen, C 1 –C 10 alkyl, aryl, C 7 –C 20 aralkyl, R 5 means hydrogen, C 1 –C 10 alkyl, aryl, C 7 –C 20 aralkyl, wherein, for R 4 and R 5 , aryl is phenyl, wherein said phenyl is optionally substituted in one or more places by halogen, OH, O-alkyl, CO 2 H; CO 2 -alkyl, —NH 2 , —NO 2 , —N 3 , —CN, C 1 –C 20 alkyl, C 1 –C 20 acyl and/or C 1 –C 20 acyloxy groups, and wherein, for R 4 and R 5 , aralkyl is benzyl or phenylethyl, wherein said benzyl or phenylethyl is optionally substituted in one or more places by halogen, OH, O-alkyl, CO 2 H, CO 2 -alkyl, —NO 2 , —N 3 , —CN, C 1 –C 20 alkyl, C 1 –C 20 acyl and/or C 1 –C 20 acyloxy groups, R 6 , R 7 each mean a hydrogen atom, or together mean an additional bond to result in a double bond on the ring between their two positions or together mean an oxygen atom to provide an epoxide ring, R 8 means a methyl group or hydrogen, and at the same time, R 1a and R 1b together stand for a trimethylene group, R 2 stands for a phenyl or benzyl radical, and X stands for a 2-methyl-4-thiazolyl or 2-methyl-4-oxazolyl radical or at the same time R 1a and R 1b together stand for a trimethylene group, R 2 stands for a methyl, ethyl or propyl group and X stands for a 2-methyl-4-thiazolyl or 2-methyl-4-oxazolyl radical or at the same time R 1a and R 1b in each case stand for a methyl group, R 2 stands for a methyl, ethyl or propyl radical, and X stands for a 2-methyl-4-thiazolyl or 2-methyl-4-oxazolyl radical, wherein the nitrogen atom and/or the sulfur atom in X can be present in oxidized form, and wherein, R 2 and R 8 each are simultaneously not a methyl radical, or a stereoisomer thereof.