Patent ID: 7619094

Claim:
A compound, or enantiomers, stereoisomers, rotamers, tautomers, and racemates of said compound, or a pharmaceutically acceptable salt, or ester of said compound, said compound of the general structure shown in Formula I: wherein: R 1 is H, OR 8 , NR 9 R 10 , or CHR 9 R 10 , wherein R 8 , R 9 and R 10 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, aryl-, heteroalkyl-, heteroaryl-, cycloalkyl-, and arylalkyl-; A and M are connected to each other (in other words, A-E-L-M taken together) such that the moiety: shown above in Formula I forms either a three, four, six, seven or eight-membered cycloalkyl; E is C(H) or C(R); L is C(H) or C(R); R, R 2 , and R 3 can be the same or different, each being independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, cycloalkyl-, heteroalkyl-, aryl-, (cycloalkyl)alkyl-, and aryl-alkyl- and Y is selected from the following moieties: wherein G is NH or O, and R 16 , R 17 , R 18 , and R 19 can be the same or different, each being independently selected from the group consisting of H, C 1 -C 10 alkyl, C 1 -C 10 heteroalkyl, C 2 -C 10 alkenyl, C 2 -C 10 heteroalkenyl, C 2 -C 10 alkynyl, C 2 -C 10 heteroalkynyl, C 3 -C 8 cycloalkyl, and aryl, or alternately: (i) R 15 and R 20 are connected to each other to form a five to six-membered heterocyclyl, and (ii) likewise, independently, R 17 and R 18 are connected to each other to form a three to eight-membered cycloalkyl, wherein each of said alkyl, aryl, cycloalkyl or heterocyclyl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of: hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, amido, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, sulfonamido, alkylsulfonamido, arylsulfonamido, keto, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halo, cyano, and nitro.