Patent ID: 7923466

Claim:
A method for the treatment of a patient suffering from a disease or disorder ameliorated by the inhibition of casein kinase Iε activity wherein said disease or disorder is selected from the group consisting of mood disorders and sleep disorders, comprising the administration of a compound of formula I or formula II, an enantiomer, or a pharmaceutically acceptable salt thereof, optionally in combination with one or more pharmaceutically acceptable carriers, diluents or excipients, wherein X is S or S(O) n ; R 1 is H or C 1 -C 6 alkyl; R 2 is NR 5 R 6 ; R 3 is aryl or heterocycle; R 4 is C 1 -C 6 alkyl or halogen; R 5 is H or C 1 -C 6 alkyl; R 6 is H or C 1 -C 6 alkyl; R 7 is CH 2 NR 8 R 9 wherein R 8 is H, C 1 -C 10 alkyl, C 3 -C 8 cycloalkyl, aryl, aryl(C 1 -C 6 alkyl), aryl(C 2 -C 6 alkenyl), diaryl(C 2 -C 6 alkenyl), heterocycle, heterocycle(C 1 -C 6 alkyl), heterocycle(C 2 -C 6 alkenyl), hydroxy(C 1 -C 6 alkyl), dihydroxy(C 2 -C 6 alkyl), acyl, C 1 -C 6 alkoxycarbonyl, aryl(C 1 -C 6 alkoxy)carbonyl, carbamoyl(C 1 -C 6 alkyl), or P; R 9 is H, C 1 -C 10 alkyl, heterocycle(C 1 -C 6 alkyl) or heterocycle(C 2 -C 6 alkenyl); or R 8 and R 9 together with the nitrogen to which they are attached form a heterocycle; and wherein P is Gly, or L- or D-Ala, Val, Leu, Ile, Ser, Cys, Thr, Met, Pro, Phe, Tyr, Trp, His, Lys, Arg, Asp, Gly, Asn or Gln; m is 0, 1 or 2; and n is 1 or 2.