Patent ID: 8846671

Claim:
A heterocyclic alkynyl benzene compound having formula (I), or a pharmaceutically acceptable salt, prodrug, or stereoisomer thereof, wherein: R 1 together with L 1 , the carbon to which L 1 is attached, Z and ring A form a moiety having the structure wherein the moiety is selected from the group consisting of L 2 is —CONH— or —NHCO—; R 2 is 1) H; 2) Halogen; 3) C 1 ˜C 5 alkyl; 4) C 3 ˜C 6 cycloalkyl; or 5) C 1 ˜C 5 alkyl substituted with one or more F atoms; R 3 is 1) H; 2) Halogen; 3) C 1 ˜C 4 alkyl; 4) C 3 ˜C 6 cycloalkyl; or 5) C 1 ˜C 4 alkyl substituted with one or more F atoms; R 5 is H, provided that R 4 is 1) H; 2) (CH 2 ) n NR 6 R 7 ; or 3) (CH 2 ) n -Het 1 ; or R 4 is H, provided that R 5 is 1) H; or 2) Het 2 ; wherein n is 0 or 1; Het 1 is a nonaromatic heterocycle containing 1 to 3 N atoms; Het 2 is an aromatic five-membered heterocycle containing 1 to 3 heteroatoms independently selected from the group consisting of N, O and S; wherein any C or N position of Het 1 and Het 2 is optionally substituted with alkyl, cycloalkyl or NR 6 R 7 ; each R 6 and R 7 is independently 1) H; 2) C 1 ˜C 3 alkyl; 3) C 1 ˜C 3 alkyl substituted with one or more F atoms; or 4) C 3 ˜C 6 cycloalkyl; or R 6 and R 7 together with the N atom to which they are attached form a penta-, hexa-, hepta- or octatomic ring, wherein the penta-, hexa-, hepta- or octatomic ring optionally further contains an O or S atom.