Patent ID: 7960523

Claim:
A method for preparing an aminoalkyl glucosaminide 4-phosphate compound having the formula: wherein R 1 , R 2 , and R 3 are each independently selected from saturated and unsaturated (C 2 -C 24 ) aliphatic acyl groups; comprising (a) reacting a compound having the formula wherein PG 2 represents a hydroxyl protecting group, with a carboxylic acid having the formula CH 3 (CH 2 ) 10 CH(OR 1 )CH 2 COOH if R 1 , R 2 and R 3 are identical acyl groups or sequentially with carboxylic acids having the formula CH 3 (CH 2 ) 10 CH(OR 1 )CH 2 COOH, CH 3 (CH 2 ) 10 CH(OR 2 )CH 2 COOH and CH 3 (CH 2 ) 10 CH(OR 3 )CH 2 COOH if R 1 , R 2 and R 3 represent two or three different acyl groups; (b) phosphorylating the 4-hydroxyl group thereby introducing a phosphate protecting group onto the 4-hydroxyl position; and (c) removing the protecting group PG 2 and the phosphate protecting group.