Patent ID: 7947807

Claim:
A method for obtaining crystals of a G protein-coupled receptor (GPCR), comprising: a) contacting said GPCR with a monovalent antibody that i. specifically binds to a three dimensional epitope of the intracellular region 3 (IC3) loop of said GPCR and ii. stabilizes the relative conformations of the transmembrane region 5 (TM5) and transmembrane region 6 (TM6) of said GPCR, under conditions that provide for binding of said antibody to said GPCR produce an antibody/GPCR complex; b) removing unbound antibody from the product of step a); and c) maintaining the product of step b) under conditions suitable for crystallizing said antibody/GPCR complex thereby producing a crystalline form of said antibody/GPCR complex.