Patent ID: 7635710

Claim:
A compound having the formula: Ar—B—Ar′ (I) wherein: —B— represents: —X—Y-Z- wherein X represents —(CH 2 ) n (wherein n is 0-6); Y represents oxygen, sulphur, or >NH; Z represents >C═O, >O or >COO; wherein at least one of X, Y and Z must be present; Ar represents an indole nucleus ring system: Ar′ represents an alpha-, beta- or gamma-pyrone nucleus ring system: wherein each of R 1-4 substitutes the ring system Ar at any available position (including the N-position) and each of R 1′ -R 2′ substitutes the ring system Ar′ at any available position and wherein each of R 1-4 and R 1′-2′ independently represents hydrogen, oxygen, halo, halo-C 1-5 alkyl, aryl, acyl, a C 5-7 heterocyclic group containing 1-3 hetero atoms independently selected from nitrogen, oxygen or sulphur; a C 6-8 heteroaryl group containing 1-3 hetero atoms independently selected from nitrogen, oxygen or sulphur, C 1-5 alkyl, C 2-5 alkenyl, C 2-5 alkynyl, aryl-C 1-5 alkyl, aryl-C 2-5 alkenyl, aryl-C 1-5 alkynyl, hydroxy-C 1-5 alkyl, nitro, amino, cyano, cyanamido, guanidino, amidino, acylamido, C 1-5 alkylamine, C 1-5 alkylamido, hydroxy, thiol, acyloxy, azido, C 1-5 alkoxy, carboxy, carbonylamido or styryl; wherein said arylalkyl, arylalkenyl, aralalkynyl, or styryl group optionally can be ring-substituted by one to four substituents independently selected from the group consisting of hydrogen, halo, halo-C 1-5 alkyl, aryl, a C 5-7 heterocyclic group containing 1-3 hetero atoms independently selected from nitrogen, oxygen and sulphur; a heteroaryl group containing 1-3 hetero atoms independently selected from nitrogen, oxygen and sulphur; C 1-5 alkyl, C 2-5 alkenyl, C 2-5 alkynyl, aryl-C 1-5 alkyl, aryl-C 2-5 alkenyl, aryl-C 2-5 alkynyl, hydroxy-C 1-5 alkyl, nitro, amino, cyano, cyanamido, guanidino, amidino, acylamido, hydroxy, thiol, acyloxy, azido, alkoxy, carboxy, carbonylamido, S-alkyl or alkylthiol; and either of R 3 or R 4 further can include or represent a bond to B; wherein Ar can be bonded to B at any position on the 5-membered ring portion of the Ar ring, including the N-position, and Ar′ can be bonded to B at any carbon on the Ar′ ring not substituted by R 1′ , and R 2′ ; or a pharmaceutically acceptable salt or stereoisomer thereof.