Patent ID: 8293813

Claim:
A compression resistant osteoinductive demineralized bone carrier matrix comprising: a crosslinked matrix, the crosslinked matrix comprising a carrier base material crosslinked with a multifunctional poly(ethylene glycol), wherein the carrier base material is a gelatin and wherein the multifunctional poly(ethylene glycol) has a functionality of about 2 to about 4; a demineralized bone matrix, wherein the demineralized bone matrix is dispersed throughout the crosslinked matrix, and wherein the osteoinductive demineralized bone carrier matrix comprises from at least 10 wt% to about 30 wt% of the carrier base material, from about 0.1% to about 4 wt% of the multifunctional poly(ethylene glycol) and from greater than about 55 wt% to about 75 wt% of the demineralized bone matrix with respect to a dry weight of the osteoinductive demineralized bone carrier matrix, and a ceramic material consisting of hydroxyapatite and calcium carbonate, wherein the demineralized bone carrier matrix, once introduced to an intramuscular implantation site, induces bone formation such that at least 1% of the implantation site is involved in new bone or cartilage.