Patent ID: 8702965

Claim:
A method of determining the concentration of an analyte in a sample, comprising: applying a sample to an electrochemical sensor strip, the senor strip including a first electrode, the first electrode including at least one first layer on a first conductor, the at least one first layer including an enzyme system and at most 8 μ/mm 2 of a mediator, where the mediator assists in transferring electrons between the analyte in the sample and the first conductor; applying a pulse sequence to the sample, the pulse sequence comprising at least 2 duty cycles within 3 to 14 seconds, where each duty cycle comprises an excitation and a relaxation, where the relaxation of each duty cycle provides an output current reduction to one-half or less of a current flow at an excitation maxima; determining current measurements from the sample responsive to the pulse sequence; and determining the concentration of the analyte in the sample from the current measurements, the determined concentration having at least one of a stability bias of less than ±10%, a hematocrit bias of less than ±10% for whole blood samples over a 20 to 60% hematocrit range, and an intercept to slope ratio of at most 20 mg/dL.