Patent ID: 8106051

Claim:
A method of enhancing the expression of apoAI, which comprises administering a therapeutically effective amount of a compound of formula (I): in which ring A is Ar 2 ; Ar 1 and Ar 2 are independently a monocyclic or bicyclic aromatic carbocyclic group that may be optionally substituted; R is a hydrogen or a lower alkyl that may be optionally substituted; Z is oxygen or sulfur; Y 1 and Y 2 are independently a hydrogen, a halogen, a lower alkyl that may be optionally substituted, a carboxy, a lower alkoxycarbonyl that may be optionally substituted, a cyano, a phenyl that may be optionally substituted, or a monocyclic aromatic heterocyclic group that may be optionally substituted, and two Y 1 s or more and two Y 2 s or more each may be different among them; n is an integer of 0 to 2; the broken line is independently the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; or a pharmaceutically acceptable salt thereof to a patient expected to enhance the expression of apoAI.