Patent ID: 8410147

Claim:
A method of treating diabetic nephropathy; the method comprises the steps of first identifying a subject suffering from diabetic nephropathy, then administering to the subject an effective amount of a compound of Formula II to treat diabetic nephropathy; wherein: Q is (CR 4 R 5 ) n3 ; n 1 is 1; n 2 is 1; n 3 is 1, 2, or 3; R 2 is R 2 -2: Ar is a monocyclic aryl or bicyclic aryl; X is from 1 to 3 substituents on Ar, and each is independently selected from the group consisting of OR 8 , NR 8 R 9 , SR 8 , SO 2 NR 8 R 9 , NR 8 SO 2 R 9 , CONR 8 R 9 , NR 8 C(═O)R 9 , NR 8 C(═O)OR 9 , OC(═O)NR 8 R 9 , and NR 8 C(═O)NR 9 R 10 ; R 3 is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, or cycloalkylalkynyl, optionally substituted; R 4 and R 5 are H; R 8 -R 10 are independently H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, or heterocycle; optionally substituted by one or more halogen or heteroatom-containing substituents selected from the group consisting of OR 11 , NR 11 R 12 , NO 2 , SR 11 , SOR 11 , SO 2 R 11 , SO 2 NR 11 R 12 , NR 11 SO 2 R 12 , OCF 3 , CONR 11 R 12 , NR 11 C(═O)R 12 , NR 11 C(═O)OR 12 , OC(═O)NR 11 R 12 , and NR 11 C(═O)NR 12 R 13 ; R 11 -R 13 are independently H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle)alkyl, (heterocycle)alkenyl, (heterocycle)alkynyl, or heterocycle; with the proviso that if X is acyclic and is connected to Ar by an oxygen or nitrogen atom, then X contains at least one additional oxygen, nitrogen or sulfur atom.