Patent ID: 7071165

Claim:
A method of rejuvenating the thymus in a subject, comprising administering to the subject an effective amount of a peptide compound which inhibits LHRH activity, wherein the peptide compound comprises a structure: A-B-C-D-E-F-G-H-I-J wherein A is pyro-Glu, Ac-D-Nal , Ac-D-Qal, Ac-Sar, or Ac-D-Pal; B is His or 4-Cl-D-Phe; C is Trp, D-Pal, D-Nal, L-Nal, D-Pal(N—O), or D-Trp; D is Ser; E is N-Me-Ala, Tyr, N-Me-Tyr, Ser, Lys(iPr), 4-Cl-Phe, His, Asn, Met, Ala, Arg or Ile; F is D-Asn or D-Gln; G is Leu or Trp; H is Lys(iPr), Gin, Met, or Arg; I is Pro; and J is Gly-NH 2 or D-Ala-NH 2 ; or a pharmaceutically acceptable salt thereof, thereby rejuvenating the thymus in the subject.