Patent ID: 8722068

Claim:
A method for abrasion of at least one biological tissue surface of a subject, comprising: delivering in a single treatment to at least one biological tissue, at least two pluralities of frozen particle compositions in a predetermined sequential order, the first plurality of frozen particle compositions; including one or more frozen particles approximately one micrometer or less; and wherein the first plurality includes two or more subsets having different therapeutic agents including at least one of ibuprofen, morphine, codeine, aspirin, acetaminophen, lidocaine/lignocaine, ropivacaine, mepivacaine, benzocaine, chloroprocaine, cocaine, cyclomethycaine, dimethocaine/larocaine, propoxycaine, procaine/novocaine, proparacaine, tetracaine/amethocaine, articaine, bupivacaine, carticaine, cincho caine/dibucaine, etidocaine, levobupivacaine, piperocaine, prilocaine, trimecaine, saxitoxin, or tetrodotoxin; and subsequently in the same treatment, delivering a second plurality of frozen particle compositions; including one or more frozen particles approximately one micrometer or less; and wherein the second plurality includes at least two subsets having different agents including one or more of, keratin, collagen, elastin, cytokine, coagulant, anti-coagulant, anti-inflammatory agent, anti-tumor agent, antimicrobial agent, epinephrine, adrenaline, or a neurotoxin.