Patent ID: 7569559

Claim:
A composition comprising a C-based diazeniumdiolate compound, wherein said composition releases NO under physiological conditions in predictable and tunable quantities and does not generate nitrosamines under physiologic conditions, wherein said C-based diazeniumdiolate compound is represented by the formula: R 3 —C(R 1 ) x (N 2 O 2 R 2 ) y I wherein x is an integer from 0 to 2 and y is an integer from 1 to 3 and the sum of x plus y equals 3; wherein R 1 is ether, thioether, amine, —NO 2 , or an electron-withdrawing group; wherein R 2 is a countercation or a protecting group on the terminal oxygen; wherein said protecting group is selected from the group consisting of aryl, glycosyl, acyl, alkyl and olefinic groups; wherein said alkyl group is selected from the group consisting of saturated alkyl, unsaturated alkyl, and functionalized alkyl; and wherein said functionalized alkyl is selected from the group consisting of 2-bromoethyl, 2-hydroxypropyl, 2-hydroxyethyl and S-acetyl-2-mercaptoethyl; wherein R 3 is an aliphatic, aromatic or cycloalkyl group, wherein said aromatic group is phenyl wherein said phenyl group is unsubstituted or substituted with mono- or di-substituted amino, unsubstituted amino, ammonium, alkoxy, acetoxy, aryloxy, acetamide, aldehyde, benzyl, cyano, nitro, thiol, sulfonic, vinyl, carboxyl, nitroso, trihalosilane, trialkylsilane, trialkylsiloxane, trialkoxysilane, diazeniumdiolate, hydroxyl, halogen, trihalomethyl, ketone, benzyl or alkylthio; wherein said aromatic group is optionally a multi-ring system wherein the multi-ring system is selected from the group consisting of acridine, anthracene, benzazapine, benzodioxepin, benzothiadiazapine, carbazole, cinnoline, fluorescein, isoquinoline, naphthalene, phenanthrene, phenanthradine, phenazine, phthalazine, quinoline, and quinoxaline; with the proviso that R 1 is not an imidate, thioimidate, amidine or enamine.