Patent ID: 8685993

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is C 1-6 alkyl, NR 3 R 6 , C 1-6 alkoxy, or â€”Sâ€”C 1-6 alkyl; R 2 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, a C 6-14 aryl group, a C 3-14 cycloalkyl group, a 5 to âˆ’14 membered heteroaryl containing 1 to 3 heteroatoms each independently selected from N, O, and S, C 1-6 alkoxy, C 2-6 -alkenyloxy, C 2-6 -alkynyloxy, C 1-6 alkyl-Oâ€”R 27 , C 1-6 alkyl-C 3-14 cycloalkyl, C 1-6 alkyl-Oâ€”C 0-6 alkyl-C 6-14 aryl, C 1-6 alkyl-Oâ€”SiR 8 R 9 R 10 , halogen, or C 1-6 haloalkyl, wherein R 2 may be unsubstituted or substituted with OH, C1-6alkoxy, or halogen; R 4 and R 5 are independently H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, a C 6-14 aryl group, a C 3-14 cycloalkyl group, a 3-14 membered cycloheteroalkyl group, a 5-14 membered heteroaryl group, C 1-6 alkoxy, OH, C 1-6 alkylNR 11 R 12 , C 1-6 alkyl-Oâ€”R 13 , C 1-6 alkyl-5-14membered heteroaryl group, or C(O)â€”C 1-6 alkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-14 aryl group, C 3-14 cycloalkyl group, 3-14 membered cycloheteroalkyl group, 5-14 membered heteroaryl group, C 1-6 alkoxy, C 1-6 alkyl-NR 11 R 12 , C 1-6 alkylOR 13 , C 1-6 alkyl-5-14 membered heteroaryl group, or C(O)â€”C 1-6 alkyl may be optionally substituted by one or more from the group of halogen, a 5-14 membered heteroaryl group, OH, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkylOR 27 , C 1-6 alkoxy, NR 14 R 15 , CONR 16 R 17 , NR 18 COR 19 , NR 20 COOR 21 , COR 22 , COOR 23 , â€”CN, SO 2 R 26 , or NR 24 SO 2 R 25 ; R 3 and R 6 are independently H, C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkoxy, a C 3-14 cycloalkyl group, a 3-14 membered cycloheteroalkyl group, a C 6-14 aryl group, a 5-14 membered heteroaryl group, or C 1-6 alkyl-Oâ€”R 8 , wherein C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkoxy, a C 3-14 cycloalkyl group, a 3-14 membered cycloheteroalkyl group, a C 6-14 aryl group, a 5-14 membered heteroaryl group, or C 1-6 alkyl-Oâ€”R 8 , may be substituted by one of more of C 1-6 alkyl, or OH; R 11 and R 12 are the same or different, and independently are selected from hydrogen, C 1-6 alkyl, a C 3-8 cycloalkyl group, a C 6-14 aryl group, a 5-14 membered heteroaryl group, and a 3-14 membered cycloheteroalkyl group, or NR 11 R 12 forms a non-aromatic four to seven membered ring optionally containing a second heteroatom selected from O, N and S, and optionally substituted by one or more substituents R 28 ; R 7 and R 7a are independently H or C 1-6 alkyl n is 0, 1, or 2; and R 8 , R 9 , R 10 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , R 26 , and R 27 , and R 28 are independently H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, a C 6-14 aryl group, A C 3-14 cycloalkyl group, a 3-14 membered cycloheteroalkyl group, or a 5-14 membered heteroaryl group.