Patent ID: 8895782

Claim:
A method for treating an ophthalmic disease or disorder resulting at least in part from lipofuscin pigment accumulation in an eye of a subject, comprising administering to the subject a pharmaceutical composition comprising a compound having the structure of Formula (E): or a pharmaceutically acceptable salt thereof, wherein: m is 0, 1, 2, or 3; R 21 and R 22 are each independently hydrogen, C 1 -C 5 alkyl or fluoroalkyl; R 3 and R 4 are each hydrogen; R 5 is aryl or carbocyclyl; each R 6 is the same or different and independently hydrogen or C 1 -C 5 alkyl; R 9 is alkyl; R 12 and R 13 are the same or different and independently hydrogen, or —C(═O)R 9 ; and each R 14 is the same or different and independently alkyl, halo, fluoroalkyl or —OR 6 .