Patent ID: 6949560

Claim:
A compound represented by formula I: wherein: Z is N; Z 1 is CH when the bond between atoms C5 and Z 1 is a single bond, and Z 1 is C when the bond between C5 and Z 1 is a double bond; R 1 is hydrogen or alkyl; R 2 is alkyl, hydroxyalkyl, optionally-substituted aralkyl, optionally-substituted cycloalkyl, heteroalkyl, optionally-substituted heterocyclyl, optionally-substituted aryl, or optionally-substituted heteroaryl; A is absent or —O—, —S(O) n —, —CHR′—, —C(═O)—, or —NR 3 —, wherein n is 0, 1, or 2, R′ is hydrogen or alkyl, and R 3 is hydrogen, alkyl, optionally-substituted aryl, optionally-substituted heteroaryl, or optionally-substituted cycloalkyl; the bond between atoms C5 and Z 1 is a single or double bond; the bond between atoms C8 and C9 is a single or double bond; and Y is an alkyl, heteroalkyl, optionally-substituted cycloalkyl, optionally-substituted aryl, or optionally-substituted heteroaryl; or isomer a pharmaceutically acceptable salt or ester or- prodrugs thereof.