Patent ID: 8173136

Claim:
A strain of Newcastle disease virus, comprising nucleotide sequences encoding NP, P, M, and L proteins of a low-pathogenic Newcastle disease virus AY845400; and nucleotide sequences encoding F and HN proteins of a high-pathogenic Newcastle disease virus KCTC 10919BP, wherein the F protein coding sequence comprised in the strain is characterized by substitution of the codon encoding the 115 th amino acid of the F protein of the high-pathogenic Newcastle disease virus with any one selected from the group consisting of alanine codons consisting of GCA, GCC, GCG and GCU; aspartic acid codons consisting of GAC and GAU; phenylalanine codons consisting of UUC and UUU; isoleucine codons consisting of AUC and AUU; leucine codons consisting of UUA and UUG; serine codons consisting of UCA, UCC, UCG and UCU; threonine codons consisting of ACC and ACU; valine codons consisting of GUA, GUC, GUG and GUU; and tyrosine codons consisting of UAC and UAU.