Patent ID: 8709416

Claim:
A method of increasing a T cell response in a human comprising administering to the subject an anti-PD-1 antibody or an antigen binding fragment thereof in combination with a potentiating agent selected from the group consisting of cyclophosphamide and an analog of cyclophosphamide, wherein administration of the anti-PD-1 antibody or antigen binding fragment thereof in combination with the potentiating agent increases a T cell response, wherein the dose of the potentiating agent is less than 200 mg/kg, wherein the dose of the potentiating agent is not effective to have direct anti-tumor activity, and wherein the T cell response achieved by the combination of anti-PD-1 antibody and the potentiating agent is greater than the T cell response achieved by administering either the anti-PD-1 antibody alone or the potentiating agent alone.