Patent ID: 7985735

Claim:
A compound of formula (I): wherein R 1 a and R 1 b are independently H or optionally substituted hydroxyl, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 2 a, and R 2 b are independently H or optionally substituted alkyl, cycloalkyl, or heterocycloalkyl; R 3 a, and R 3 b are independently H or optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; both R 5 a and R 6 a, and R 5 b and R 6 b, are carbon atoms linked by a covalent bond or by an optionally-substituted alkylene or alkenylene group of 1 to 8 carbon atoms where one to three carbon atoms can be replaced by N, O, S(O) n , or C═O; R 17 a and R 17 b are independently —OH, lower alkoxy, or lower alkyl; R 7 a, R 7 b, R 8 a, R 8 b are independently H or optionally substituted hydroxyl, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; or R 7 a and R 8 a, or R 7 b and R 8 b, or both, can be linked by an optionally-substituted alkylene or alkenylene group of 3 to 8 carbon atoms where one to three carbon atoms can be replaced by N, O, S(O) n , or C═O; each n can be the same or different and is 0, 1, or 2; Xa is —O—, —N(La—R 10 a)-, —S—, optionally-substituted —C(La—R 10 a)=CH—, —C(O)—O—, —C(O)—N(La—R 10 a)-, —N═C(La—R 10 a)-; Xb is —O—, —N(Lb-R 10 b)-, —S—, optionally-substituted —C(Lb-R 10 b)=CH—, —C(O)—O—, —C(O)—N(Lb-R 10 b)-, —N═C(Lb-R 10 b)-; La and Lb are independently a covalent bond or C 1 —C 4 alkylene; Wa, Wb, R 10 a, and R 10 b are defined in paragraphs (a) through (c), which follow: (a) when Wa and Wb together are a Linker, then Xa or Xb are independently —O—, —S—, or —C(O)—O—; R 10 a and R 10 b, respectively, are absent; or (b) when Wa and Wb together are a Linker; Xa is —N(La—R 10 a)-, —C(La—R 10 a)=CH—, —N═C(La—R 10 a)-, or —C(O)—N(La—R 10 a)- ; Xb is —N(Lb-R 10 b)-, —C(Lb-R 10 b)=CH—,—N═C(Lb-R 10 b)-, or —C(O)—N(Lb-R 10 b)-; R 10 a and R 10 b are independently H or optionally substituted hydroxyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; or (c) when Wa and Wb together are a Linker; Xa is —N(La—R 10 a)-, —C(La—R 10 a)=CH—, —N═C(La—R 10 a)-, or —C(O)—N(La—R 10 a)-; Xb is —N(Lb-R 10 b)-, —C(Lb-R 10 b)=CH—, —N═C(Lb-R 10 b)-, or —C(O)—N(Lb-R 10 b)-; R 10 a and R 10 b together are a Linker; or a pharmaceutically acceptable salt thereof.