Patent ID: 7820633

Claim:
A method for inducing an immune response to human Her2 in an animal comprising administering to the animal a recombinant nucleic acid molecule which encodes an analogue of human Her2 which is immunogenic in humans, said analogue comprising continuous sequence of at least amino acid residues 1-654 of SEQ ID NO: 4, which is modified with at least one foreign TH epitope at one or more positions selected from the group consisting of amino acid residues 5-25, 59-73, 103-117, 149-163, 210-224, 250-264, 325-339, 369-383, 465-479, 579-593, 632-652, 653-667, 661-675, 695-709, and 710-730, wherein said at least one foreign TH epitope is present as an insertion or results from a substitution, and wherein said analogue of human Her2 comprises a substitution of no more than 150 of amino acids 1-654 of SEQ ID NO:4.