Patent ID: 8168627

Claim:
A compound of the formula wherein n is an integer selected from 0 to 3; wherein dotted lines represent optional bonds; wherein R 2 is selected from the group consisting of hydrogen and C 1 -C 3 lower alkyl; wherein R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, nitrile, —COCH 3 , —SO 2 CH 3 , NO 2 , OCH 3 , SCH 3 , alkylsulfoxide, alkylsulfone, alkyl, methyl, and halogenated methyl; wherein at least one of R 3 and R 4 is not hydrogen; wherein D is selected from the group consisting of wherein W 1 and W 2 are independently selected from the group consisting of —CH 2 —, oxygen and sulphur; wherein Y is selected from the group consisting of -MCH 2 CH 2 —, —CH 2 MCH 2 —, and —CH 2 CH 2 M-; wherein M is selected from the group consisting of —O—, —S—, —SO 2 —, and —CH 2 —; wherein E is selected from the group consisting of phenylene and mono-substituted pyridyl; wherein Z 1 is a hydrocarbon moiety which contains at least one carbonyl, sulfone or sulfoxide group or nitrogen atom separated from E by none to four intervening atoms, and said nitrogen atom being an amine, an amide, an N-oxide, or a quaternary ammonium salt, said hydrocarbon moiety optionally containing other oxygen, sulphur, or nitrogen atoms; and wherein Z 2 is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, trifluoromethyl, alkoxy, C 1 -C 5 straight or branched alkyl, C 2 -C 5 straight or branched alkenyl, and C 2 -C 5 straight or branched alkynyl; or a pharmaceutically acceptable salt thereof.