Patent ID: 8741909

Claim:
A compound of formula (I) wherein R 1 is H, a saturated or unsaturated, branched or unbranched C 1-15 alkyl chain, wherein optionally one or more carbons is/are replaced by a heteroatom selected from O, N, S(O) p , wherein said chain is optionally substituted by one or more groups independently selected from oxo, halogen, an aryl group, a heteroaryl group, a carbocyclyl group or a heterocyclyl group, each aryl, heteroaryl, carbocyclyl or heterocyclyl group bearing: 0 to 3 substituents selected from halogen, -hydroxyl, —C 1-6 alkyl, —C 1-6 alkoxy, —C 2-3 alkoxyOC 1-3 alkyl, —C 2-3 alkylOC 1-3 alkyl, —C 1-3 hydroxyalkyl, —C 1-6 haloalkyl, amino, —C 1-4 mono or —C 2-8 di-alkyl amino, —C 1-4 mono or —C 2-8 di-acyl amino, —C 0-6 alkylS(O) p C 1-6 alkyl, —C 0-6 alkylS(O) p NR 6 R 7 , —C 0-6 alkylNR 8 C 0-6 alkylS(O) p C 1-6 alkyl, —C 0-6 alkylC(O)OC 0-6 alkyl, —NR 8 C 0-6 alkylC(O)NR 6 R 7 —NR 8 C 0-6 alkylC(O)C 0-6 alkyl, —C 0-6 alkylC(O)NR 6 R 7 , and —C 0-6 alkylC(O)C 1-6 alkyl; and/or one aryl, heterocyclyl or carbocyclyl; X is C 6-10 aryl or a C 5-9 heteroaryl each substituted by R 2a and by R 2b wherein R 2a is selected from hydrogen, —C 1-3 alkyl, halo, hydroxyl, cyano, —C 1-3 haloalkyl, —C 1-3 alkoxy, —C 2-3 alkoxyOC 1-3 alkyl, —C 2-3 alkylOC 1-3 alkyl, —C 1-3 hydroxyalkyl, —C 0-6 alkylS(O) q C 1-3 alkyl, —C 0-6 alkylS(O) p NR 6 R 7 , —C 0-6 alkylNR 8 C 0-6 alkylS(O) p C 1-6 alkyl, —C 0-6 alkylC(O)OH, —C 0-6 alkylC(O)OC 1-6 alkyl, —NR 8 C 0-6 alkylC(O)NR 6 R 7 , —NR 8 C 0-6 alkylC(O)C 1-6 alkyl, —C 0-6 alkylC(O)NR 6 R 7 and —C 0-6 alkylC(O)C 1-6 alkyl; and R 2b is selected from hydrogen, C 1-3 alkyl, halo, hydroxyl, cyano, —C 1-3 haloalkyl, —C 1-3 alkoxy, and —C 0-6 alkylS(O) q C 1-3 alkyl; R 3a is hydroxyl; R 3b is selected from hydrogen, hydroxyl, halo, cyano, —C 1-3 haloalkyl, —C 1-3 hydroxyalkyl, —C 1-3 alkoxy, and —S(O) q C 1-3 alkyl; R 4 is hydrogen or —C 1-3 alkyl; R 5 is hydrogen or —C 1-3 alkyl; R 6 is hydrogen or —C 1-6 alkyl; R 7 is hydrogen or —C 1-6 alkyl; R 8 is hydrogen or —C 1-6 alkyl; P is 0 or an integer 1 or 2; q is 0 or an integer 1 or 2 or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and deuterated compounds thereof.