Patent ID: 7786152

Claim:
A method of treating a condition or disease associated with 11β-HSD selected from the group consisting of diabetes, obesity; hypertension; glaucoma; arthritis; asthma; osteroporosis; intra-uterine growth retardation; apparent mineralocorticoid excess syndrome (AME); polycystic ovary syndrome (PCOS; hirsutism; acne; oligo- or amenorrhea; adrenal cortical ademoma and carcinoma; Cushing's syndrome; artheroscelerosis; myocardial infarction; insulin resistance; congnitive impairment; breast cancer; and endomertrial cancer, comprising administering an effective amount of a compound to an individual in need thereof wherein the compound is a compound having Formula III wherein R 4 is selected from H and hydrocarbyl, R 5 is a hydrocarbyl group and L is an optional linker group, wherein R 3 is H or a substituent and wherein X is selected from S, O, NR 6 and C(R 7 )(R 8 ), wherein R 6 is selected from H and hydrocarbyl groups, wherein each of R 7 and R 6 are independently selected from H and hydrocarbyl groups.