Patent ID: 8598138

Claim:
A siRNA-cochleate composition comprising: a cochleate; and a short interfering ribonucleic acid (siRNA) associated with the cochleate; wherein the siRNA is associated with a positively charged amphiphile, wherein the positively charged amphiphile is a compound of formula (I): wherein: R is selected from H, a C2-C26 acyl group and a C4-C26 aliphatic group; R 1 is selected from R 2 and R 3 are each independently a C4-C26 aliphatic group; optionally one or more of R, R 2 and R 3 is: R 4 and R 5 are each independently a C3-C20 aliphatic group; n is an integer from 1 to 3; and X − is an anion of a pharmaceutically acceptable compound.