Patent ID: 6949640

Claim:
A method for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine which comprises: a) reacting the anionic form of a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; wherein the purine is substituted at position 6 with a member selected from the group consisting of halogen, amino, and protected amino; b) reacting the product from a) with an alkoxide to provide 2-chloro-6-alkoxy purine nucleoside; and c) reacting the 2-chloro-6-alkoxy purine nucleoside with ammonia to provide the 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine.