Patent ID: 7196106

Claim:
A compound represented by formula I: or a pharmaceutically acceptable salt or solvate thereof wherein: R 1 is selected from the group consisting of: H, C 1-10 alkyl, Aryl, Heteroaryl and Heterocyclyl, said alkyl, Aryl, Heteroaryl and Heterocyclyl being optionally substituted with one to four substituents independently selected from R 6 ; R 2 represents NR 4 R 5 , R 3 is selected from the group consisting of: C 1-10 alkyl and Aryl, said alkyl and Aryl being optionally substituted with one to four substituents independently selected from R 6 ; R 4 is selected from H and C 1-10 alkyl, R 5 is C 1-10 alkyl having 1–2 R 6 groups attached; R 6 is independently selected from the group consisting of halo, C 1-7 alkyl, Aryl, Heteroaryl, Heterocyclyl, OR 7 , SR 7 , S(O) m R 8 , S(O) 2 OR 8 , S(O) m NR 7 R 8 , NO 2 , NR 7 R 8 , O(CR 9 R 10 ) n NR 7 R 8 , C(O)R 8 , CO 2 R 7 , CO 2 (CR 9 R 10 ) n CONR 7 R 8 , OC(O)R 8 , CN, C(O)NR 7 R 8 , NR 7 C(O)R 8 , OC(O)NR 7 R 8 , NR 7 C(O)OR 8 , NR 7 C(O)NR 8 R 9 , CR 7 (NOR 8 ), (CR 9 R 10 ) n -Aryl, (CR 9 R 10 ) n -Heteroaryl, (CR 9 R 10 ) n -Heterocyclyl, CF 3 and OCF 3 ; wherein m is 0, 1 or 2 and n is an integer from 1 to 7, and the alkyl, Heterocyclyl, Aryl and Heteroaryl groups and portions are optionally substituted with 1–4 substituents selected from a group independently selected from R 11 ; R 7 , R 9 and R 10 are independently selected from the group consisting of: H, C 1-7 alkyl, Aryl, Ar—C 1-10 alkyl and mono-, di- and tri- halo substituted Ar—C 1-10 alkyl, or one R 9 and one R 10 are taken together with the atoms to which they are attached and any intervening atoms and represent a ring of 3 to 8 members containing 0–2 heteroatoms independently selected from 0, S and N; R 8 is selected from the group consisting of: C 1-10 alkyl, Aryl and C 1-10 alkyl-Aryl; and R 11 is selected from the group consisting of: halo, CN, C 1-4 alkyl, Aryl, CF 3 and OH.