Patent ID: 8513284

Claim:
A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof: wherein Q represents the residue of a phenyl ring optionally substituted with one or more substituents selected from the group consisting of C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkyl(C 1-6 )alkyl, heteroaryl, heteroaryl(C 1-6 )alkyl, hydroxy, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulphinyl, C 1-6 alkylsulphonyl, C 2-6 alkylcarbonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, halogen, cyano and trifluoromethyl; W represents C—R′; Alk 1 represents a straight or branched C 1-3 alkylene chain optionally substituted with one or more substituents selected from the group consisting of trifluoromethyl, aryl, oxo, hydroxy, C 1-6 alkoxy, C 2-6 alkoxycarbonyl(C 1-6 )alkoxy, aminocarbonyl(C 1-6 )alkoxy, trifluoromethoxy, aminocarbonyl, C 1-6 alkylaminocarbonyl and di(C 1-6 )alkylaminocarbonyl; L 1 represents oxygen or N—R 2 ; Y represents pyridopyrimidin-4-yl; R 1 represents hydrogen, halogen, C 1-6 alkyl or C 1-6 alkoxy; R 2 represents hydrogen or C 1-6 alkyl; R a represents trifluoromethyl; or C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkoxy(C 1-6 )alkyl, C 1-6 alkylthio, C 1-6 alkylsulphonyl, hydroxy, hydroxy(C 1-6 )alkyl, amino(C 1-6 )alkyl, cyano, trifluoromethyl, oxo, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, amino, C 1-6 alkylamino, di(C 1-6 )-alkylamino, phenylamino, pyridinylamino, C 2-6 alkylcarbonylamino, C 2-6 alkoxycarbonyl-amino, and aminocarbonyl; and R b represents hydrogen, C 1-6 alkyl or C 3-7 cycloalkyl.