Patent ID: 8110672

Claim:
An isolated nucleic acid comprising a mutated PL teto-1 promoter, wherein said mutated PL teto-1 promoter has a sequence comprising SEQ ID NO:34 with a mutation selected from the group consisting of: a) a replacement of a T with a C at nucleotide position 12, 38, 39, 46, 52, 58, 60, 72, 73, 76, 79, 89, 99, 102, 108, 109, 114, 118, 120, 121, 127, or 133; b) a replacement of an A with G at nucleotide position 12, 15, 16, 18, 19, 20, 26, 32, 35, 37, 39, 40, 41, 48, 49, 50, 51, 53, 59, 65, 81, 87, 94, 97, 101, 105, 107, 119, 122, 126, 128, 130 or 138; c) a replacement of a C with A at nucleotide position 21; d) a replacement of an A with C at nucleotide position 23, 62, 87, 101, 105, 113, 126, or 128; e) a replacement of a T with A at nucleotide position 24; f) a replacement of a C with T at nucleotide position 31 or 135; g) a replacement of an A with T at nucleotide position 49, 51, 62, or 87; h) a replacement of a G with A at nucleotide position 64, 67, 86, 98, 100, 125, 129 or 131; i) a replacement of a T with G at nucleotide 109; j) a deletion of T at nucleotide position 24; k) a deletion of T at nucleotide position 25; l) a deletion of T at nucleotide position 28; m) an insertion of C between nucleotide positions 88 and 89; n) an insertion of T between nucleotide positions 96 and 97; and any combination thereof.