Patent ID: 8043627

Claim:
A method for the production of an implant or of a scaffold for tissue engineering having a coating of an osteogenic matrix composite, wherein the osteogenic matrix composite is a composite of collagen and at least one non-collagenic extracellular matrix (ECM) component, comprising the steps of: producing non-crosslinked collagen fibrils by means of fibrillogenesis after integrating the at least one non-collagenic ECM component to the collagen component by adding the at least one non-collagenic ECM component, re-suspending in water or in a buffer the collagen fibrils thus produced, and subsequently immobilizing the collagen fibrils on the surface of the implant or the scaffold in a dip-coating process, wherein the collagen fibrils are formed by a process of self-aggregation of collagen monomers.