Patent ID: 7745454

Claim:
A method for treating a disease in a patient, said disease selected from the group consisting of asthma and multiple sclerosis which method comprises administering to said patient a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of formula (Ia) or (Ib): wherein: Ar 1 is pyrimidinyl optionally substituted with 1-3 substituents selected from the group consisting of alkyl, substituted alkyl, amino, substituted amino, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic; R is selected from the group consisting of alkyl, alkoxy, halo, and mono- and dialkyl-amino; q is an integer from 0 to 2; R 1 is selected from the group consisting of hydrogen and alkyl; Y is CH or N; R 2 is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, and substituted cycloalkenyl; and X is selected from the group consisting of hydroxyl, alkoxy and substituted alkoxy; or an enantiomer, diastereomer or pharmaceutically acceptable salt thereof; wherein the compound of Formula I(a) or I(b) has a binding affinity to VLA-4 as expressed by an IC 50 of about 15 μM or less.