Patent ID: 7794747

Claim:
A method for producing a cationic liposomal preparation comprising: (a) mixing an organic solvent with a taxane and a cationic lipid to form an organic solution; (b) mixing the organic solution of step (a) with an aqueous solution comprising a stabilizing agent to form a dispersion of cationic liposomes, wherein the dispersion comprises cationic liposomes in an aqueous medium and wherein the pH value of the aqueous medium is between 3 and 7; (c) homogenising the dispersion of step (b) at least once; (d) sterile filtrating the dispersion obtained in step (c); and, (e) dehydrating the dispersion of cationic liposomes of step (d) to form a cationic liposomal preparation; wherein the cationic liposomes in the dispersion of step (b) comprise at least one cationic lipid in an amount of at least about 30 mol % and a taxane in an amount of at least about 2 mol %; and wherein the stabilizing agent in the dispersion of step (b) is present in an amount of about 0.1% (m/v) to about 20% (m/v).