Patent ID: 8524675

Claim:
A compound having the following structure (I): or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: Q 1 is alkyl optionally substituted with hydroxyl or amino, Q2 is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, —C(=NH)NR 7 R 8 , Q 3 is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, —C(=NH)NR 7 R 8 , each R 1 and R 2 is, independently, hydrogen or an amino protecting group; each R 3 is, independently, hydrogen or a hydroxyl protecting group; each R 4 , R 5 , R 7 and R 8 is, independently, hydrogen or C 1 -C 6 alkyl optionally substituted with one or more halogen, hydroxyl or amino; each R 6 is, independently, hydrogen, halogen, hydroxyl, amino or C 1 -C 6 alkyl; or R 4 and R 5 together with the atoms to which they are attached can form a heterocyclic ring having from 4 to 6 ring atoms, or R 5 and one R 6 together with the atoms to which they are attached can form a heterocyclic ring having from 3 to 6 ring atoms, or R 4 and one R 6 together with the atoms to which they are attached can form a carbocyclic ring having from 3 to 6 ring atoms, or R 7 and R 8 together with the atom to which they are attached can form a heterocyclic ring having from 3 to 6 ring atoms; each R 9 is, independently, hydrogen, hydroxyl, amino or C 1 -C 6 alkyl optionally substituted with one or more halogen, hydroxyl or amino; each R 10 is, independently, hydrogen, halogen, hydroxyl, amino or C 1 -C 6 alkyl; or R 9 and one R 10 together with the atoms to which they are attached can form a heterocyclic ring having from 3 to 6 ring atoms; each R 11 is, independently, hydrogen or methyl; and n is an integer from 0 to 4, and wherein (i) at least one of Q 2 and Q 3 are other than hydrogen, and (ii) if Q 1 is methyl, ethyl, i-propyl, i-butyl, —(CH 2 ) 2 OH, —CH 2 CH(OH)(CH 2 ) 2 NH 2 , —C(=O)H, —C(=O)CH(OH)CH 2 NH 2 , —C(=O)CH(OH)(CH 2 ) 2 NH 2 , —C(=O)CH(OH)(CH 2 ) 3 NH 2 , —C(=O)CH(OH)(CH 2 ) 4 NH 2 , —C(=O)N(OH)(CH 2 ) 2 NH 2 , —C(=O)CH 2 NH 2 , —C(=O)(CH 2 ) 4 NH 2 —C(=O)CH 2 NHC(CH 3 ) 3 , —C(=O)CH(CH(CH 2 ) 2 )NH 2 , —C(=O)CHNH 2 (CH 2 ) 4 NH 2 , —C(=O)(CH 2 ) 2 C(CH 3 ) 2 CH(CH 3 )OH, —C(=O)CH(OH)CH 2 NH 2 , —C(=O)OC(CH 3 ) 3 , —C(=O)(CH 2 ) 4 OH, —C(=O)CH 3 or —C(=O)NH(CH 2 ) 2 NH 2 , then Q 2 is not methyl, and (iii) if Q 1 is —C(=O)CH(OH)(CH 2 ) 2 NH 2 , then Q 3 is not —C(=O)CH(OH)(CH 2 ) 2 NH 2 .