Patent ID: 7115586

Claim:
A method for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water, said active ingredient being a drug, cosmetic additive, food additive or agrochemical, said method comprising combining said active ingredient with β-cyclodextrin in an aqueous complexation medium, said medium comprising from about 0.1% to about 80% (weight/volume) of β-cyclodextrin; from about 0.1% to about 10% (weight/volume) pharmacologically inactive and pharmaceutically, cosmetically or agriculturally acceptable water-soluble polymer which is a polysaccharide, a polypeptide, a cellulose derivative, a polyoxyethylene derivative, a polyvinyl derivative or a copolymer of acrylic acid; and from about 0.1% to about 5% (weight/volume) of a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with β-cyclodextrin and its inclusion complexes, said charged compound being pharmaceutically, cosmetically or agriculturally acceptable, said negatively-charged compound being a salt of a monofunctional carboxylic acid which forms a non-inclusion complex with β-cyclodextrin or a salt of a carboxylic acid having a lipophilic moiety which forms an inclusion complex with β-cyclodextrin.