Patent ID: 7968583

Claim:
A compound of formula (I): wherein: R is an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl or aryl; R1 is selected from NHCOR4, NHSO 2 R10, NR5R6, R8R9N—C 1 -C 6 alkyl and R7O—C 1 -C 6 wherein: R4 is selected from an optionally further substituted heterocycloalkyl, aryl, NR8R9, and R7O—C 1 -C 6 alkyl; R5 is hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl, aryl, R8R9N—C 2 -C 6 alkyl, and R7O—C 2 -C 6 alkyl, R6, is an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl, aryl, R8R9N—C 2 -C 6 alkyl and R7O—C 2 -C 6 alkyl; R7 is selected from hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl, aryl and R8R9N—C 2 -C 6 alkyl; R8 and R9, being the same or different, are independently selected from hydrogen, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl and aryl, or R8 and R9, taken together with the nitrogen atom to which they are bonded, form an optionally substituted heterocycloalkyl group; R10 is an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocycloalkyl or aryl; A, B, D and E represent a nitrogen atom, CH, CR2 or CR3, with a maximum of two of A, B, D and E representing a nitrogen atom, and with a maximum of two of A, B, D and E representing CR2 or CR3, wherein: R2 and R3, being the same or different, are independently selected from halogen, trifluoromethyl, nitro, OR7, NR8R9, an optionally further substituted straight or branched C 1 -C 6 alkyl, R8R9N—C 1 -C 6 alkyl and R7O—C 1 -C 6 alkyl, wherein R7, R8, and R9 are as defined above; Ra and Rb, being the same or different, are selected from hydrogen or methyl, with the proviso that: when A, D and E are CH, and B is CR2, wherein R2 is 4-methylpiperazine or morpholine, then R1 is not NHCOR4 wherein R4 is pyrrolidin-2-yl; or isomers, tautomers, carriers, and pharmaceutically acceptable salt thereof.