Patent ID: 8734792

Claim:
A method of treating a human diagnosed with an autoimmune disease or autoimmune disorder, comprising administering to said human an effective amount of a humanized monoclonal blocking antibody that specifically binds to human CD22 comprising a heavy chain variable domain comprising variable heavy (VH) complementarity determining regions (CDRs) and a light chain variable domain comprising variable light (VL) CDRs, wherein said blocking antibody specifically binds to an epitope associated with the first two Ig-like domains of native human CD22, wherein said blocking antibody comprises: a VH CDR1 having the amino acid sequence GYYMH (SEQ ID NO:33); a VH CDR2 having the amino acid sequence AVNPNTAGLTYNQRFKD (SEQ ID NO:39); a VH CDR3 having the amino acid sequence VDYDDYGYWFFDV (SEQ ID NO: 45); a VL CDR1 having the amino acid sequence KASENVVTYVS (SEQ ID NO:55): a VL CDR2 having the amino acid sequence GASNRYT (SEQ ID NO:61); and a VL CDR3 having the amino acid sequence GQGYSYPYT (SEQ ID NO:67), and wherein said method reduces the number of B cells or B cell subsets in the human.