Patent ID: 8481493

Claim:
A non-porous film having an average pore size of less than 1 μm as determined by scanning electron microscope, comprising a collagen polypeptide comprising at least one GXY domain having a length of at least 5 consecutive GXY triplets, wherein X and Y each represent any amino acid and wherein at least 20% of the amino acids of said collagen polypeptide are present in the form of consecutive GXY triplets, wherein the film has a thickness, when placed in demineralized water of 37° C. for 24 hours, is at most 10 times its initial thickness, wherein the film is crosslinked by: (i) adding between 0.02 millimol and 5.0 millimol of a crosslinking compound per gram collagenous polypeptide, or (ii) exposing the film to radiation so that the degree of crosslinking is the equivalent of adding between 0.02 millimol and 5.0 millimol of a crosslinking compound per gram collagenous polypeptide.