Patent ID: 7759471

Claim:
A nucleotide monomer comprising: a compound of structure I having a 2′-hydroxyl protecting group: wherein B is selected from a base and a base including a base protecting group; wherein R 1 and R 2 are each independently selected from H, a hydroxyl protecting group, and wherein either R 1 or R 2 is wherein R 3 is selected from an alkyl group, an aryl group, a substituted alkyl, and a substituted aryl group; wherein R 4 and R 5 are each independently selected from an alkyl group, an aryl group, a substituted alkyl, and a substituted aryl group; and wherein 2HPG is a 2′-hydroxyl protecting group selected from one of the following groups: Group II: wherein R 6 , R 7 , and R 8 are each independently selected from an alkyl group, an aryl group, a substituted alkyl group, and a substituted aryl group; Groups VIIa and VIIb: wherein R 6 and R 7 are independently selected from an alkyl group, an aryl group, a substituted alkyl with an electron-withdrawing group, and a substituted aryl group with an electron-withdrawing group, wherein R 11 is selected from an ester protecting group and a silyl protecting group, wherein each R 12 is one or more groups, wherein R 12 is bonded to a carbon on the ring, wherein each R 12 is selected from an alkyl group, an aryl group, a substituted alkyl with an electron-withdrawing group, and a substituted aryl group with an electron-withdrawing group; and Group VIII: wherein R 6 and R 7 are independently selected from an alkyl group, an aryl group, a substituted alkyl with an electron-withdrawing group, and a substituted aryl group with an electron-withdrawing group, wherein SR 14 includes one or more groups, wherein each SR 14 is attached to one of the carbons in the carbon ring, wherein each SR 14 is a thioether selected from a thioalkyl group, a thioaryl group, a substituted thioalkyl group, a substituted thioaryl group, wherein R 14 is selected from an alkyl group, an aryl group, a substituted alkyl group, a substituted aryl group, and wherein SG includes one or more groups, wherein each SG is attached to one of the carbons in the carbon ring, wherein each SG is selected from H, an alkyl group, an aryl group, a substituted alkyl with an electron-donating group, a substituted aryl group with an electron-donating group, and an electron-donating group in the ortho or para position to the thioether SR 14 .