Patent ID: 7335659

Claim:
A compound, or a pharmaceutically acceptable salt thereof, having the formula 1, wherein: R e and ′R e are OH, optionally independently etherified or esterified; Z is —C(R 4 ,R 5 )—, wherein R 4 and R 5 are independently (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; R 1 is H, halogen, CF 3 , or (1C-4C)alkyl; R 2 and R 3 are independently H, halogen, —CF 3 , —OCF 3 , (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH 2 ) m ,X, wherein X is halogen or phenyl and m=2-4; —O(CH 2 ) m NR a R b , —S(CH 2 ) m NR a R b or —(CH 2 ) m NR a R b , wherein m=2-4 and wherein R a , R b are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, —CF 3 , —OCF 3 , —CN, —NO 2 , —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1 C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or R a and R b form a 3-8 membered ring structure, optionally substituted with halogen, —CF 3 , —OCF 3 , —CN, —NO 2 , hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1 C-8C)alkyl.