Patent ID: 8466283

Claim:
A compound having the formula: or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof, wherein: R 1 is —(CH 2 ) n —(CHR 4 )—(CH 2 ) m —N(R 5 )(R 5′ ); R 2 is a heteroaryl optionally substituted with 1, 2 or 3 R 6 groups; R 3 is alkyl or cycloalkyl; R 4 is hydrogen, hydroxy or alkoxy; R 5 and R 5′ may be the same or different and are independently, hydrogen, alkyl, cycloalkylalklyl, or alkoxyalkyl or R 5 and R 5′ may be taken together with the nitrogen atom to which they are bound to form a 3-7 membered nitrogen containing heterocyclic ring optionally containing at least one additional heteroatom selected from oxygen, nitrogen or sulfur and which may be optionally substituted with 1 or more R 6′ groups, or R 4 and R 5 may be taken together with the atoms to which they are bound to form a 5-6 membered nitrogen containing heterocyclic ring optionally containing 1 or more nitrogen, oxygen or sulfur atoms and which may be optionally substituted with 1 or more R 6′ groups; each occurrence of R 6 may be the same or different and is independently halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalklyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic ring, heterocyclylalkyl, alkyl-OR 7 , alkyl-SR 7 , alkyl-N(R 7 )(R 7′ ), alkyl-COR 7 , —CN, —COOR 7 , —CON(R 7 )(R 7′ ), —OR 7 , —SR 7 , —N(R 7 )(R 7′ ), or —NR 7 COR 7 each of which may be optionally substituted with 1 or more R 8 groups; each occurrence of R 6′ may be the same or different and is independently alkyl, cycloalkylalklyl, or alkyl-OR 7 ; each occurrence of R 7 and R 7′ may be the same or different and is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalklyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclic ring, heterocyclylalkyl, or heteroarylalkyl; each occurrence of R 8 is independently nitro, hydroxy, cyano, formyl, acetyl, halogen, amino, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkylalklyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclic ring, heterocyclylalkyl, or heteroarylalkyl; n is an integer from 1-4 and m is an integer from 0-4 with the proviso that when R 4 and R 5 are taken together with the atoms to which they are bound to form a 3-7 membered nitrogen containing ring, n+m≦4.