Patent ID: 8293788

Claim:
A method for treating psoriasis, ulcerative colitis, melanoma, angiogenesis, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of ischemia-reperfusion injury, comprising administering to a patient in need thereof a therapeutically effective amount of a 2-(R)-phenylpropionic acid derivative compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R′ group is selected from: H, OH and when R′ is H, R is selected from H, C 1 -C 5 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 5 -alkenyl, C 1 -C 5 -alkoxy; an heteroaryl group selected from substituted and unsubstituted pyridine, pyrimidine, pyrrole, thiophene, furane, indole, thiazole, oxazole; an amino acid residue consisting of straight or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -phenylalkyl, substituted with one further carboxy (COOH) group; a residue of formula —CH 2 —CH 2 —Z—(CH 2 —CH 2 O) n R′ wherein R′ is H or C 1 -C 5 -alkyl, n is an integer from 0 to 2 and Z is oxygen or sulfur; a residue of formula —(CH 2 ) n —NRaRb wherein n is an integer from 0 to 5 and each Ra and Rb, which may be the same or different, are C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl or, alternatively, Ra and Rb together with the nitrogen atom to which they are bound, form a heterocycle from 3 to 7 members of formula (II), wherein W represents a single bond, O, S, N-Rc, Rc being H, C 1 -C 6 -alkyl or C 1 -C 6 -alkylphenyl, and n is an integer from 0 to 3, a residue of formula SO 2 Rd wherein Rd is C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, aryl and heteroaryl; when R′ is OH, R is selected from H, C 1 -C 5 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 5 -alkenyl.