Patent ID: 6906213

Claim:
Process for the preparation of a phosphine-aminophosphine compound having formula 1 R 2 P—L—N(R 3 )—PR 1 R 2 1 which comprises (1) contacting a compound having formula 2 R 2 P—L—NHR 3 2 with phosphorus trihalide PX 3 in the presence of an inert, organic solvent and an acid acceptor to produce intermediate compound having formula 3 and (2) contacting intermediate compound 3 with a reactant having the formula R 1 —M 1 , R 2 —M 1 or a mixture thereof; wherein R, R 1 , R 2 , and R 3 are, independently, substituted or unsubstituted, branched- or straight-chain C 1 -C 20 alkyl, substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 6 -C 20 carbocyclic aryl, or substituted or unsubstituted C 4 -C 20 heteroaryl having one to three heteroatoms wherein the heteroatoms are selected from sulfur, nitrogen, or oxygen; L is a divalent chiral radical selected from substituted or unsubstituted, branched- or straight-chain C 1 -C 20 alkylene, substituted or unsubstituted C 3 -C 8 cycloalkylene, substituted or unsubstituted C 6 -C 20 carbocyclic arylene, substituted or unsubstituted C 4 -C 20 heteroarylene having one to three heteroatoms wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen, or substituted or unsubstituted metallocenylmethylene, wherein L is substantially enantiomerically pure, X is halide; and M 1 is a metal selected from Group I or Group II.