Patent ID: 8895750

Claim:
A compound of the formula (I) Cy is phenyl, pyrazolyl, pyridinyl, pyrrolyl, imidazolyl, thiazolyl, furanyl, oxazolyl, isoxazolyl, thienyl, pyridazinyl, pyrimidinyl, pyrazinyl or pyranyl each is substituted by R 1 and optionally substituted by halogen, halo C 1-4 alkyl, C 1-4 alkyl and C 1-4 alkoxy; R 1 is chosen from: L-Ar and —S(O) m —R 3 , each R 1 is optionally substituted by Br, C 1-4 alkyl, R 3 —S(O) 2 —, —CN, —C(O)—NH(R 3 ) and C 1-3 alkoxy; L is a linker chosen from a bond, O, >C(O), —(CH 2 ) n —, —O—(CH 2 ) n —, —N(R 3 )—, —N(R 3 )—(CH 2 ) n —, —(CH 2 ) n —N(R 3 )—, —C(O)—N(R 3 )—, —C(O)—N(R 3 )—(CH 2 ) n —, —N(R 3 )—C(O)—N(R 3 )—, —N(R 3 )—C(O)—, —S(O) m —N(R 3 )—, R 3 —S(O) m —, and —N(R 3 )—S(O) m —, wherein the —CH 2 — in each L can have 1-2 hydrogens replaced by C 1-3 alkyl, said C 1-3 alkyl groups can optionally cyclize to form a C 3-6 cycloalkyl ring; Ar is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzoxazolyl, indolyl, isoindolyl, benzofuranyl, benzimidazolyl, benzothiazolyl, piperidinyl, piperazinyl or pyrrolidinyl; Ring A of the formula (I) is an N-linked heterocycle chosen from C 5 -C 10 spirocycle and a nitrogen containing optionally bridged mono- or bi-cyclic heterocycle, each Ring A is substituted by one Y and optionally substituted by halogen, halo C 1-4 alkyl, C 1-4 alkyl and C 1-4 alkoxy; Y is —(CH 2 ) n —N(R 3 )—R 4 , or Y is R 4 ; R 4 is wherein R 5 cannot be hydrogen each n is independently 1-4; each m is independently 0-2; each R 2 and R 3 are independently chosen from hydrogen or C 1-4 alkyl; each R 5 is independently chosen from hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylC 1-4 alkoxy, C 1-4 alkylhydroxy, —(CH 2 ) n -heterocycle and heterocycle each heterocycle optionally substituted by halogen, OH or R 2 —S(O) m —; each group defined above for Cy, R 1 —R 5 , and Y can be where possible partially or fully halogenated; or a pharmaceutically acceptable salt thereof.