Patent ID: 8865655

Claim:
A compound of the general Structure VII Including pharmaceutically acceptable salts thereof, wherein R 1 , R 2 (where X=—CONR 6− ), and R 3 are the same or different and each represents an amino-acid side chain moiety selected from the group consisting of: —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, -L′-O—C(O)—R′, -L″-C(O)—O—R″, -L′-A, -L′-N R″R″, -L-Het-C(O)-Het-R″ and -L′-Het-R″, wherein L′ is a C 2 -C 6 alkylene group and A is phenyl or a 5- to 6-membered heteroaryl group, each R′ is the same or different and represents C 1 -C 4 alkyl, each R″ is the same or different and represents H or C 1 -C 6 alkyl, each Het is the same or different and is a heteroatom spacer selected from —O—, —N(R″′)— and —S—, and each R″′ is the same or different and represents H or C 1 -C 4 alkyl; R 7 is selected from —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl or -L′-A; R 2 (where X=—CHZ—), R 4 and R 6 are the same or different and each represents hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or, C 2 -C 6 alkynyl; K represents a linear or branched chain of 1-10 atoms containing carbon atoms and other atoms; L represents SPr 1 , wherein Pr 1 is H or a protecting group that forms a thioether, a monothio, dithio or aminothioacetal, a thioester or a carbamine acid thioester to protect a thiol group; and Z is a heteroatom bonded to the macrocycle by a single or double bond, and any other group bonded to Z is H or a protecting group.