Patent ID: 8618163

Claim:
A compound of the structure: wherein: a dashed line represents the presence or absence of a bond; each R 1 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, or halide; R 4 is H or C 1 -C 6 alkyl; each R 5 is independently H, C 1 -C 6 alkyl, cycloalkyl, aryl, fused aryl, alkenyl, alkynyl, halide, hydroxy, alkoxy, trifluoromethyl, acetyl, â€”OCF 3 , â€”SCF 3 , nitroso, cyano, thioalkyl, â€”S(O)Me, â€”S(O) 2 Me, â€”S(O) 2 NH 2 , or â€”C(O)OR 6 , wherein R 6 is H or C 1 -C 6 alkyl; each X is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, or each X taken together forms a cycloalkyl moiety, or each X taken together forms a substituted double bond; E 1 is O or NH; E 2 is O or NR 7 , wherein R 7 is H or C 1 -C 6 alkyl; n is 0-2; m is 0-5; and p is 1 or 2; or pharmaceutically acceptable salts, hydrates, solvates, tautomers, enantiomers, and diastereomers thereof.