Patent ID: 8546353

Claim:
A sulphated hyaluronan oligomer or polymer (HAmer) having the general formula: [R 1 β1-3] n1 GlcNR 2 β1-4[GlcAβ1-3GlcNR 3 ] n2 [β1-4R 4 ] n3 (I) wherein; R 1 is non-reducing group, which is GlcA or its beta-elimination product containing a double bond between 4- and 5-position of the uronic acid ring (delta-hexuroronic acid); R 2 and R 3 are independently either H or acetyl or 3-10 C-alkyl or alkanoyl derivative of the amine or sulphate amide, the R 3 may also vary at each position of the chain; R 4 is a reducing end group, which is GlcA or its reducing end derivative including preferably reducing (aldehyde containing) and non-reducing (aldehyde derivative) reducing end structures; n1 and n3 are integers being either 0 or 1, n2 is an integer varying from 2-50, when n3 is 0 the reducing end GlcN may be derivatized as described for R 4 ; the GlcN residue may be further derivatized by sulphate residue at position 2 or 4 or 6, and GlcA residue(s) may be optionally derivatized by sulphate residue at position 2 or 3, and wherein at least 50% of sulphate residues of the HAmer are linked to the 6-position of the GlcN residue and having 0.1 to 1.5 sulphate residues per dimer as defined by variable n2 of Formula I.