Patent ID: 8025886

Claim:
A construct comprising: a receptor tyrosine kinase (RTK) binding domain, at least one flanking domain, and at least one linkage that connects the RTK binding domain to the at least one flanking domain; wherein the RTK binding domain comprises an amino acid sequence that is identical to a mammalian VEGF-A RTK binding domain amino acid sequence; wherein the construct and the RTK binding domain bind to the extracellular domain of at least one receptor tyrosine kinase selected from the group consisting of: human VEGFR-1 and human VEGFR-2; and wherein the at least one flanking domain comprises an amino acid sequence that is identical to an amino acid sequence selected from the group consisting of: a mammalian VEGF-C amino-terminal propeptide; a mammalian VEGF-C carboxy-terminal propeptide, and fragments of the mammalian VEGF-C carboxy-terminal mammalian propeptide that retain one or more BR3P homology domains of the full-length mammalian VEGF-C carboxy-terminal propeptide.