Patent ID: 6930123

Claim:
A benz[f]indole compound of formula (I), or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein; R 1 is selected from group (a) or (c) wherein; (a) is C 2 -C 20 alkyl, C 2 -C 20 haloalkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl or carbocyclic radical, or (c) is the group -(L)-R 80 ; where, -(L)- is a divalent linking group of 1 to 12 atoms selected from carbon and hydrogen; and where R 80 is a group selected from (a); R 2 is hydrogen, (C 1 -C 4 ) alkyl, (C 2 -C 4 )alkenyl, —O—(C 1 -C 3 alkyl), —S—(C 1 -C 3 alkyl), (C 3 -C 4 )cycloalkyl, —CF 3 , halo, —NO 2 , —CN, or —SO 3 ; R 3 is -(L 3 )-Z, where -(L 3 )- is a bond and Z is selected from an oxime amide or oxime thioamide group represented by the formulae, wherein X is oxygen or sulfur, R a is independently selected from hydrogen, C 1 -C 8 alkyl, aryl, C 1 -C 8 alkaryl, C 1 -C 8 alkoxy, aralkyl and —CN; R 4 is the group, hydrogen, CONH 2 , CONHR 4b or -(La)-(COOH) wherein -(L a )-, is OCH 2 ; or the group -(L h )-(N-hydroxyfunctional amide group); wherein -(L h )-, is OCH 2 ; and wherein the N-hydroxyfunctional amide group is represented by the formula: wherein R 4a is selected from the group consisting of OH, (C 1 -C 6 )alkoxy, and aryloxy; and wherein R 4b is hydrogen or an organic substituent selected from the group consisting of (C 1 -C 8 )alkyl, aryl, (C 7 -C 14 )aralkyl, (C 7 -C 14 )alkaryl, (C 3 -C 8 )cycloalkyl and (C 1 -C 8 )alkoxyalkyl; R 5 is selected from hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 ) alkynyl, (C 7 -C 12 )aralkyl, (C 7 -C 12 )alkaryl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, phenyl, toluyl, xylenyl, biphenyl, (C 1 -C 8 )alkoxy, (C 2 -C 8 )alkenyloxy, (C 2 -C 8 )alkynyloxy, (C 2 -C 12 )alkoxyalkyl, (C 2 -C 12 )alkoxyalkyloxy and (C 1 -C 12 )alkylamino; and wherein R 6 , R 7 , R 8 , and R 9 are independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 ) alkynyl, (C 7 -C 12 )aralkyl, (C 7 -C 12 )alkaryl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, phenyl, toluyl, xylenyl, biphenyl, (C 1 -C 8 )alkoxy, (C 2 -C 8 )alkenyloxy, (C 2 -C 8 )alkynyloxy, (C 2 -C 12 )alkoxyalkyl and (C 1 -C 12 )alkylamino.