Patent ID: 8841417

Claim:
A binding protein comprising an antigen binding domain, said binding protein capable of binding human IL-1β, said antigen binding domain comprising six CDRs: CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, as defined below: CDR-H1: X 1 -Y-D-M-S (SEQ ID NO:190), wherein; X 1 is K or R; CDR-H2: Y-X 2 -S-X 4 -G-G-X 7 -G-T-Y-Y-P-D-X 14 -X 15 -K-G (SEQ ID NO: 191), wherein; X 2 is I or V; X 4 is S or H; X 7 is G or A; X 14 is T or S; and X 15 is V or A; CDR-H3: G-G-V-X 4 -K-G-X 7 -F-D-X 10 (SEQ ID NO: 192), wherein; X 4 is T or Y; X 7 is Y or C; and X 10 is V, E, L, M, Q, or Y; CDR-L1: R-A-S-G-N-I-X 7 -X 8 -X 9 -L-X 11 (SEQ ID NO:193), wherein; X 7 is H, Y, or W; X 8 is N, G, T, Q, E, H, D, or K; X 9 is Y or W; and X 11 is T, A, or N; CDR-L2: X 1 -A-K-X 4 -L-X 6 -X 7 (SEQ ID NO:194), wherein; X 1 is N, Q, or D; X 4 is T, N, I, E, or S; X 6 is A, M, or E; and X 7 is D, E, S, or A; and CDR-L3: Q-X 2 -F-W-X 5 -X 6 -P-X 8 -X 9 (SEQ ID NO:195) wherein; X 2 is H or Q; X 5 is S, N, T, K, R, or M; X 6 is I or L; X 8 is Y or A; and X 9 is T, I, and N except that: CDR-H2 cannot be Y-I-S-S-G-G-G-G-T-Y-Y-P-D-T-V-K-G (SEQ ID NO: 18); CDR-H3 cannot be G-G-V-T-K-G-Y-F-D-V (SEQ ID NO: 19); CDR-L1 cannot be R-A-S-G-N-I-H-N-Y-L-T (SEQ ID NO:20); CDR-L2 cannot be N-A-K-T-L-A-D (SEQ ID NO: 21); and CDR-L3 cannot be Q-H-F-W-S-I-P-Y-T (SEQ ID NO: 22).