Patent ID: 7727980

Claim:
A compound of the formula: wherein: R 1 is hydrogen, F, Cl, Br, I, NO 2 , OR 12 , SR 12 , SOR 12 , SO 2 R 12 , NR 12 R 12 , C 1 -C 8 alkyl, C 1 -C 8 haloalkyl or C 1 -C 8 heteroalkyl, wherein the alkyl, haloalkyl and heteroalkyl groups are optionally substituted; R 2 is F, Cl, Br, I, CH 3 , CF 3 , CHF 2 , CH 2 F, CF 2 Cl, CN, CF 2 OR 12 , CH 2 OR 12 , OR 12 , SR 12 , SOR 12 , SO 2 R 12 , NR 12 R 13 , C 1 -C 8 haloalkyl, C 1 -C 8 heteroalkyl, C 2 -C 8 alkenyl or C 2 -C 8 alkynyl, wherein the haloalkyl, heteroalkyl, alkenyl and alkynyl groups are optionally substituted; R 3 through R 8 each independently is hydrogen, F, Cl, Br, I, OR 12 , NR 12 R 13 , SR 12 , SOR 12 , SO 2 R 12 , C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 heteroalkyl, C 2 -C 8 alkynyl, C 2 -C 8 alkenyl, aryl, heteroaryl or arylalkyl, wherein the alkyl, haloalkyl, heteroalkyl, alkynyl, alkenyl, aryl, heteroaryl and arylalkyl groups are optionally substituted; or R 3 and R 5 taken together form a bond; or R 5 and R 7 taken together form a bond; or R 4 and R 6 taken together form a three- to eight-membered saturated or unsaturated carbocyclic or heterocyclic ring, wherein the carbocyclic or heterocyclic ring may be optionally substituted; or R 6 and R 8 taken together form a three- to eight-membered saturated or unsaturated heterocyclic ring, wherein the heterocyclic ring may be optionally substituted; R 9 and R 10 each independently is hydrogen, F, Cl, Br, I, CN, OR 12 , NR 12 R 13 , C m (R 12 ) 2m OR 13 , SR 12 , SOR 12 , SO 2 R 12 , NR 12 C(O)R 13 , C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 heteroalkyl or arylalkyl, wherein the alkyl, haloalkyl, heteroalkyl and arylalkyl groups are optionally substituted; R 12 is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 heteroalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, heteroaryl or aryl, wherein the alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, heteroaryl and aryl groups are optionally substituted; R 13 is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 heteroalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, heteroaryl or aryl, wherein the alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, heteroaryl and aryl groups are optionally substituted; X is O or S; Y is O, S, N{R 12 }, N{OR 12 } or CR 12 R 13 ; Z is N{R 12 }; n is 0, 1 or 2; m is 0, 1, or 2; and pharmaceutically acceptable salts thereof.