Patent ID: 8263107

Claim:
A method of forming a coating on an implantable device, comprising (a) subjecting a polymer to ozonation to form a peroxy grafted polymer, (b) subjecting the peroxy grafted polymer to a process of reduction or CO 2 +H 2 O plasma treatment followed by immersion into an organic acid solution to generate a functionalized polymer, (c) attaching a biofunctional compound to the functionalized polymer, and (d) forming a coating on the implantable device comprising the polymer prior to ozonation or forming a coating on the implantable device comprising the functionalized polymer with the biofunctional compound attached thereon, wherein the organic acid is selected from the group consisting of maleic acid, fumaric acid, cinimanic acid, and a combination thereof, wherein the biofunctional compound is an RGD peptide, YIGSR peptide, ANP peptide, elastin, an endothelial progenitor cell (EPC) capturing antibody, an endothelial cell adhesion molecule (ECAM), or combinations thereof.