Patent ID: 7968545

Claim:
A compound of formula III-B: or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 taken together with the nitrogen atom to which they are bound and form a ring selected from x is 1-2; z is 0-3; each occurrence of R 4 is independently C 1-4 alkyl optionally substituted with hydroxy,C 1-4 alkoxy, halo, C 1-4 alkylcarbonyloxy or carbo(C 1-4 alkoxy); each occurrence of R 5 is independently halo, oxo, hydroxy, trifluoromethyl, —O—C 1-4 alkyl, C 1-4 alkyl optionally substituted with hydroxy, amino, aminocarbonyl, di(C 1-4 alkyl) aminocarbonyl; each occurrence of R 6 is independently R′, —COR′, —CO 2 (C 1-6 aliphatic), —CON(R′) 2 , or —SO 2 R′; R 7 is selected from —OH, —OCH 3 , —OC(O)CH 3 , —OP(O)(ONa) 2 , or —OC(O)NHCH 3 ; and each occurrence of R′ is independently selected from hydrogen or an optionally substituted group selected from C 1-8 aliphatic, C 6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms.