Patent ID: 7410781

Claim:
A nucleic acid molecule encoding fusion polypeptide (R1) x -(R2) y -F, wherein R1 is an interleukin-4 receptor α (IL-4Rα) component comprising a first amino acid sequence of amino acid residues 1-231 of SEQ ID NO:2, wherein one or more amino acids at positions 67, 68, 71, 152. 164, 171, 172, 175 and 198 are modified; R2 is an interleukin-13 receptor α1 (IL-13Rα1) component comprising a second amino acid sequence of amino acid residues 27-343 of SEQ ID NO:3, wherein said second amino acid sequence may comprise one to three modifications; F is a multimerizing component; and x and y are each independently a positive integer ≧1.