Patent ID: 7119229

Claim:
Colchicine derivative of the following formula (I) and pharmaceutically acceptable salts thereof: wherein: when R 1 is N(R6)-A, N(A) 2 or X 2 -A, R 2 is X 3 R 7 , R 3 and R 4 are independently hydrogen or a methyl group, R 5 is hydrogen, or a methyl group, wherein R 6 and R 7 are independently hydrogen or a lower alkyl group, X, X 1 , and X 3 are independently O or S, and X 2 is S; when R 2 is X 2 C(X 1 )-A or X 2 -A, R 1 is N(R 6 )COCH 3 , N(R 6 )COCF 3 , or NHC(O)OR 8 , R 3 and R 4 are independently hydrogen or a methyl group, R 5 is hydrogen or a methyl group, wherein R 6 is hydrogen or a lower alkyl group, R 8 is a lower alkyl, alkenyl, or substituted or unsubstituted aryl, and X, X 1 and X 2 are independently O or S; when R 3 and R 4 are independently C(X 1 )-A or -A, R 1 is N(R 6 )COCH 3 , N(R 6 )COCF 3 , or NHC(O)OR 8 , R 2 is X 3 R 7 , R 5 is hydrogen or a methyl group, wherein R 6 and R 7 are independently hydrogen or a lower alkyl group, R 8 is a lower alkyl, alkenyl, or substituted or unsubstituted aryl, and X, X 1 and X 3 are independently O or S; wherein A is represented by the formula (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j): wherein Y 1 is a C 3 to C 10 straight chain or branched alkyl or a substituted C 5 to C 7 cycloalkyl group; Hal is halogen; R 9 is hydrogen or a lower alkyl group; n 1 is an integer from 1 to 6; n 2 and n 3 are independently an integer from 1 to 5; n 4 is an integer from 0 to 3; and n 5 is an integer from 1 to 6.