Patent ID: 7314638

Claim:
A method for preparing a tamsulosin HCl sustained-release tablet, which comprises the steps of: (A) dissolving tamsulosin HCl in a solvent and then dissolving a first hydroxypropylmethylcellulose phthalate in the tamsulosin HCl to prepare a binder solution; (B) kneading the binder solution with an excipient mixture comprising a second hydroxypropylmethylcellulose phthalate and glyceryl dibehenate, and granulating the kneaded material to provide granules; and (C) compressing the granules into a tablet; wherein in step (A), the amount of the first hydroxypropylmethylcellulose phthalate is 10 to 150 parts by weight relative to 1 part by weight of tamsulosin HCl, and in step (B), the amount of the second hydroxypropylmethylcellulose phthalate in the excipient mixture is 50 to 500 parts by weight relative to 1 part by weight of tamsulosin HCl and the amount of the glyceryl dibehenate in the excipient mixture is 10 to 200 parts by weight relative to 1 part by weight of tamsulosin HCl.