Patent ID: 6958212

Claim:
A biomaterial formed from the cross-linking of two or more precursor components, wherein at least one of said precursor components has the formula: D—Y—C(O)—(CH 2 ) n —S—(CH 2 ) 2 —CO—X—P, D—Y—C(O)—(CH 2 ) n —NH—(CH 2 ) 2 —CO—X—P, D—Y—C(O)—(CH 2 ) n —NH—U—P, D—Y—(O)—CH 2 n —S—U—P, D—Y—C(O)—(CH 2 ) 2 —S—L—S—CH 2 —CH 2 —CO—X—P, D—Y—C(O)—CH 2 ) 2 —S—L—S—U—P, D—Y—C(O)—CH 2 ) 2 —NH—L—S—CH 2 —CH 2 —CO—X—P, D—Y—C(O)—(CH 2 ) 2 —NH—L—S—U—P, D—Y—C(O)—(CH 2 ) 2 —S—L—NH—CH 2 —CH 2 —CO—X—P, D—Y—C(O)—CH 2 ) 2 —S—L—NH—U—P, D—Y—C(O)—(CH 2 ) 2 —NH—L—NH—CH 2 —CH 2 —CO—X—P, or D—Y—C(O)—(CH 2 ) 2 —NH—L—NH—U—P, wherein D is a pharmaceutically active moiety; n is 1 or 2; is O, NH, or N; L is a linear or branched linker; X is O or N; P is a water-soluble polymer comprising one or more conjugated unsaturated groups or a water-swellable polymer comprising one or more conjugated unsaturated groups; and L is the product of the addition of a nucleophilc to an electrophilic group that is attached to said polymer.