Patent ID: 7345043

Claim:
A compound of the formula: wherein: R is selected from the group consisting of hydrogen, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyl and substituted alkyl; R 12 is selected from the group consisting of —NR 14 OH, —OH, —NR 14 R 15 , —OR 14 , —(C 1 -C6)alkylene-SR 14 , —(C 1 -C 6 )alkylene-OR 14 , —(C 1 -C 6 )alkylene-NR 14 R 15 , —CF 3 ; where R 14 and R 15 are independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )substituted alkyl, aryl, substituted aryl and where R 14 and R 15 together with the nitrogen atom bound thereto form a heterocyclic or substituted heterocyclic ring; Y is ═C(R 11 )—, and Z is ═(R 14 )—; or wherein Y or Z are bonded to C(O)R 12 ; R 11 is hydrogen or alkyl; the ring defined by A above is a piperidine or piperazine ring, wherein A is bonded to the five-membered ring of ring A at a nitrogen; T is —SO 2 —[(C 1 -C 3 )alkylene] p -or, —SO 2 NR 16 —[(C 1 -C 3 )alkylene] p where p is zero or one and R 16 is hydrogen, alkyl, aryl, or heteroaryl, provided that when T is connected to A at a nitrogen atom and T is —SO 2 NR 16 —[(C 1 -C 3 )alkylene] p then p is not zero; and tautomers and pharmaceutically acceptable salts thereof.