Patent ID: 8178688

Claim:
Benzamidine derivative of the formula 1 or pharmaceutically acceptable salts thereof: wherein R 1 is C 3 -C 6 cycloalkyl; phenyl; benzyl; pyridinyl; guanidino; NR 6 R 7 ; CH 2 NR 6 R 7 ; wherein A is C 1 -C 6 alkyl and n is an integer of 2 to 6; C 1 -C 6 alkyl which is substituted by pyridine; or pyridinyl which is substituted by C 1 -C 6 alkyl; R 2 is hydrogen; C 1 -C 6 alkyl; C 3 -C 6 cycloalkyl; phenyl; benzyl; C 1 -C 6 alkyl which is substituted by hydroxy, C 1 -C 6 alkoxy, halogen or C 3 -C 6 cycloalkyl; or C 2 -C 6 alkenyl; R 3 and R 4 , each independently, are hydrogen; halogen; hydroxy; C 1 -C 6 alkyl which is unsubstituted or substituted halogen; C 3 -C 6 cycloalkylamino; C 1 -C 6 alkoxy; C 1 -C 6 alkanoyloxy; C 2 -C 6 alkenyloxy; phenyl-C 1 -C 6 alkoxy; phenoxy; C 2 -C 6 alkenoyloxy; phenyl-C 1 -C 6 alkanoyloxy; C 3 -C 6 cycloalkyloxy which is substituted by carboxy, esterified carboxy or amidated carboxy; or aminooxy; R 5 is hydrogen or hydroxy; R 6 and R 7 , each independently, are hydrogen; C 1 -C 6 alkyl; phenyl; benzyl; pyridinyl; C 1 -C 6 alkyl which is substituted by pyridine or carbonyl which is substituted by C 1 -C 6 alkyl, phenyl, benzyl, pyridine or C 1 -C 6 alkanesulfonyl; C 1 -C 6 alkyl which is substituted by hydroxy or C 1 -C 6 alkoxy; or acetyl which is substituted by hydroxy or C 1 -C 6 alkoxy; Y is oxygen; sulfur; NR 6 ; or CH 2 ; X 1 and X 3 , each independently, are oxygen; sulfur; NH; N—C 1 -C 6 alkyl; N—C 3 -C 6 cycloalkyl; N-benzyl; or N-phenyl; X 2 is C 3 -C 7 alkylene.