Patent ID: 8003096

Claim:
A method for enhancing recruitment of stem cells and/or progenitor cells selected from the group consisting of bone marrow stem cells, bone marrow progenitor cells, and combinations thereof, said method comprising: identifying a subject suffering from a disease or condition that would benefit from enhanced recruitment of stem cells and/or progenitor cells; introducing to the subject a plasmin modulator, wherein the plasmin modulator is a plasmin activator selected from the group consisting of plasmin, plasminogen, chimeric plasminogen, tissue-type plasminogen activator, tenecteplase, urokinase-type plasminogen activator, alpha-enolase, staphylokinase, streptokinase, sulodexide, T-686 ((3E,4E)-3-benzylidene-4-(3,4,5-trimethoxy-benzylidene) pyrrolidine-2,5-dione), an antibody against plasminogen activator inhibitor, an antibody against alpha-2-antiplasmin, and microplasmin; and introducing to the subject a myelopoietic agent selected from the group consisting of G-CSF, M-CSF, IL- 3 , SCF, VEGF, VEGF-B, VEGF-C, VEGF-D, PlGF, PDGF-A, PDGF-C, PDGF-D, erythropoietin, and Flt3-ligand; so as to enhance recruitment of the stem cells and/or progenitor cells.