Patent ID: 7101892

Claim:
A compound of formula (I): Ar—SO 2 —CR 2 R 3 -L-N(R 1 ) 2 I wherein: the R 1 groups complete a heterocyclic ring system which is an azabicyclo[2.2.1]heptane ring, wherein said system is unsubstituted or substituted with up to 3 substituents selected from halogen, CN, NO 2 , CF 3 , R 4 , OR 5 , SR 5 , N(R 6 )R 5 , CO 2 R 5 , OCOR 4 , COR 5 , CON(R 6 )R 5 , N(R 6 )COR 4 , N(R 6 )SO 2 R 4 , CON(R 6 )OR 6 , C(R 5 )═NOR 6 and ═X; X represents N—OR 6 , or CR 7 R 8 ; R 4 represents phenyl, naphthyl or heterocyclyl, any of which is unsubstituted or substituted with up to 3 substituents selected from halogen, CN, NO 2 , CF 3 , OH, OCF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxycarbonyl, C 2-6 acyl and C 2-6 acyloxy; or R 4 represents a nonaromatic hydrocarbon group of up to 10 carbon atoms which is unsubstituted or substituted with up to 3 halogen atoms or with one substituent selected from CN, NO 2 , CF 3 , OCF 3 , C 1-6 alkoxy, C 1-6 alkoxycarbonyl, C 2-6 acyl, C 2-6 acyloxy, N(R 9 ) 2 and phenyl, phenoxy, phenylthio, naphthyl or heterocyclyl, any of which is unsubstituted or substituted with up to 3 substituents selected from halogen, CN, NO 2 , CF 3 , OH, OCF 3 , C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxycarbonyl, C 2-6 acyl and C 2-6 acyloxy; R 5 represents H or R 4 ; R 6 represents H or C 1-6 alkyl; or R 5 and R 6 bonded to the same nitrogen atom may complete pyrrolidine, piperidine morpholine, piperazine or tetrahydropyridine ring; R 7 and R 8 independently represent H or a hydrocarbon group of up to 10 carbon atoms, or together complete a hydrocarbon ring of up to 14 members; R 2 and R 3 independently represent H, hydrocarbon of up to 6 carbon atoms, C 2-6 acyl, C 1-6 alkoxycarbonyl or hydroxyC 1-6 alkyl, or together complete a hydrocarbon ring of up to 6 carbon atoms; L is a linking group selected from: (a) —CR 2a R 3a —(CH 2 ) n —; (b) —O—CH 2 CH 2 —; (c) —CH 2 CH(OH)CH 2 —; (d) —CH═CH—CH 2 —; and (e) —C≡C—CH 2 —; R 2a and R 3a have the same definition as R 2 and R 3 ; n is 1, 2 or 3; Ar represents phenyl, naphthyl or heteroaryl, any of which is unsubstituted or substituted with up to 3 substituents selected from halogen, CN, NO 2 , CF 3 , OCF 3 , R 9 , OR 9 , CO 2 R 9 and COR 9 ; and R 9 represents H or a hydrocarbon group of up to 7 carbon atoms; or a pharmaceutically acceptable salt or N-oxide thereof.