Patent ID: 7629488

Claim:
A process for the preparation of a compound of formula (I) wherein is phenyl; each R 41P is independently selected from C 1-6 alkyl, C 1-6 alkoxy or fluoro; R J and R K are each independently selected from hydrogen or C 1-4 alkyl; alternatively, R J and R K are taken together with the nitrogen atom to which they are bound to form a five to seven membered heterocyclyl; Pg 1 is a nitrogen protecting group; comprising reacting a compound of formula (X), wherein X P is selected from OH, CN, —CO 2 H, —C(O)—Cl or —C(O)—OC 1-4 alkyl and wherein y P is selected from Br, Cl or I, to yield the corresponding compound of formula (XII); reacting the compound of formula (XII) with a compound of formula (XVIII); in the presence of palladium catalyst; in the presence of an organic or inorganic base; in an organic solvent; at a temperature greater than about room temperature; to yield the corresponding compound of formula (XIX); reacting the compound of formula (XIX) with hydrogen or a source of hydrogen; in the presence of a catalyst; in a solvent; at a temperature greater than about room temperature; to yield the corresponding compound of formula (XX); reacting the compound of formula (XX) with an aqueous base; in an organic solvent; to yield the corresponding compound of formula (I).