Patent ID: 7081472

Claim:
A substituted bis-indole derivatives of formula (I) or a mental complex, wherein said metal complex consisting of bis-indole derivatives of formula (I) and a radioactive or non-radioactive metal ion of an element with an atomic number selected from the group consisting of 21 to 32, 37 to 39, 42 to 44, 49, 50 or 57 to 83, and wherein the formula (I) is hereunder: a pharmaceutically acceptable salt thereof wherein: L represents a single bond or an optionally substituted linking agent (Li) which covalently links together the carbon atoms being respectively in positions 2 or 3 and 2′ or 3′ on the heterocyclic indole rings, (Li) being an optionally substituted alkylene group; R 1 and R 2 are optional substituents of any free position of the phenyl rings of the indolyl groups and are each independently selected from halogen atoms, straight chain alkyl groups of 1 to 6 carbon atoms, branched chain alkyl groups of 3 to 7 carbon atoms, cycloalkyl groups of 3 to 7 carbon atoms, alkoxy groups of 1 to 6 carbon atoms, nitro, trifluoromethyl, cyano, carboxylic acid, sulfonic acid, carboxylic acid esters wherein the ester group derives from an alkyl group having 1 to 4 carbon atoms, substituted or unsubstituted carboxamides CO—NR 4 R′ 4 and substituted or unsubstituted amines NR 4 R′ 4 wherein R 4 and R′ 4 are each independently selected from hydrogen and optionally substituted C 1 –C 20 branched chain or straight chain alkyl groups or C 6 –C 20 aryl groups or C 6 –C 20 alkylaryl groups; R 3 is an optional substituent of the linking agent (Li) and is selected from optionally substituted aryl groups and optionally substituted branched chain or straight chain alkyl groups; q, p and r are integers indicating the number of the respective substituents R 1 , R 2 and R 3 and are each independently selected from 0 to 4, provided that r is 0 when L is a single bond; C 1 and C 2 are metal chelating agent-containing substituents of the heterocyclic rings of the indolyl groups; m and n are integers indicating the number of the respective metal chelating agent-containing substituents C 1 and C 2 and are each 0 or 1, provided that the sum of m and n is at least 1; and wherein R 1 , R 2 or R 3 independently does not represent a heterocycle or heteroaryl, and wherein R 1 , R 2 or R 3 independently is not substituted with a heterocycle or heteroaryl.