Patent ID: 7432284

Claim:
A compound of the formula: wherein X is O; Y is CR 1 R 2 , CH 2 CH 2 CR 1 R 2 ; Z is CH 2 or CH 2 CH 2 ; R 1 is hydrogen, C 1-3 alkyl; R 2 is hydrogen, hydroxy or C 1 ; R 3 is chloro, bromo, cyano, C 1-10 alkyl, C 3-7 cycloalkyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, aryl and heteroaryl groups are either unsubstituted or independently substituted with 1, 2 or 3 groups selected from fluoro, chloro, cyano, OR a , LR d or MLR d ; R 4 is hydrogen; R 5 is hydrogen or fluoro; R 6 is OR a or O(C═O)R c ; R 7 is hydrogen, chloro or methyl; R 8 and R 9 are each hydrogen; or R 8 and R 9 , when taken together with the carbon atom to which they are attached, form a carbonyl group; R 10 is C 1-10 alkyl, or (cycloalkyl)alkyl wherein said alkyl and (cycloalkyl)alkyl groups are unsubstituted or substituted with 1-5 fluoro; R a is hydrogen, C 1-10 -alkyl and phenyl, wherein said alkyl group is optionally substituted with a group selected from hydroxy, amino, O(C 1-4 alkyl), NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , phenyl, or 1-5 fluoro, and wherein said phenyl groups can either be unsubstituted or substituted with 1-3 substituents independently selected from C 1-4 alkyl, OH, O(C 1-4 alkyl), NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , halo, CN, NO 2 , CO 2 H, CO 2 (C 1-4 alkyl), C(O)H or C(O)(C 1-4 alkyl); R b is hydrogen, C 1-10 alkyl, benzyl or phenyl, wherein said phenyl group can either be unsubstituted or substituted with 1-3 substituents independently selected from C 1-4 alkyl, OH, O(C 1-4 alkyl), NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , halo, CN, NO 2 , CO 2 H, CO 2 (C 1-4 alkyl), C(O)H or C(O)(C 1-4 alkyl); R c is hydrogen, C 1-10 alkyl or phenyl, wherein said phenyl group can either be unsubstituted or substituted with 1-3 substituents independently selected from C 1-4 alkyl, OH, O(C 1-4 alkyl), NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , halo, CN, NO 2 , CO 2 H, CO 2 (C 1-4 alkyl), C(O)H or C(O)(C 1-4 alkyl); or R a and R c , whether or not on the same atom, can be taken together with any attached and intervening atoms to form a 4-7 membered ring; R d is NR b R c , OR a , CO 2 R a , O(C═O)R a , CN, NR c (C═O)R b , CONR a R c , SO 2 NR a R c or a 4-9 membered mono- or bi-cyclic N-heterocycloalkyl ring that can be optionally substituted with 1-3 C 1-3 alkyl and can be optionally interrupted by O, S, NR c , or C═O; R e is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, phenyl or phenylalkyl, wherein said alkyl, alkenyl, or phenyl group can either be unsubstituted or substituted with 1-3 substituents independently selected from C 1-3 alkyl, OH, O(C 1-4 alkyl), NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , halo, CN, NO 2 , CO 2 H, CO 2 (C 1-4 alkyl), C(O)H or C(O)(C 1-4 alkyl); L is CR b R c , C 2-6 alkylene or C 2-6 alkenylene, wherein said alkylene and alkenylene linkers can be optionally interrupted by O, S, or NR c ; M is O, S, NR c , C═O, O(C═O), (C═O)O, NR c (C═O) or (C═O)NR c ; or a pharmaceutically acceptable salt thereof.