Patent ID: 7901690

Claim:
A method of inducing an immune response against human immunodeficiency virus (HIV) or an HIV epitope in a primate, the method comprising: administering to the primate a nucleic acid composition comprising (a) at least four sets of nucleic acid molecules encoding wild-type HIV gp120 envelope glycoproteins, wherein the sets of nucleic acid molecules encode glycoproteins from primary isolates B715, Ba-L, and Czm, and from a clade E primary isolate, and (b) a set of nucleic acid molecules encoding a wild-type HIV gag protein from a primary isolate; and thereafter administering to the primate a protein composition comprising a plurality of sets of isolated wild-type HIV envelope glycoprotein molecules of each of the primary isolates in (a), wherein the nucleic acid composition and the protein composition are administered in amounts sufficient to induce an immune response against HIV or an HIV epitope in the primate.