Patent ID: 7575745

Claim:
A method for inhibiting a p30 polypeptide-mediated cellular response in a subject comprising: (a) administering to the subject an antibody that binds to p30 polypeptide, wherein the p30 polypeptide: i) has an apparent molecular weight of about 30 kDa as determined by reducing SDS-PAGE; ii) has a pI of about 7 to 8.5; iii) when present in a 2% NP 40, pH 7.0, 150 mM NaCl detergent extract binds to a herpes virus entry mediator (HVEM) polypeptide or a lymphotoxin β receptor (LTβR) polypeptide, wherein the antibody inhibits binding of a cell surface expressed p30 polypeptide to a cell surface expressed herpes virus entry mediator (HVEM) or a lymphotoxin β receptor (LTβR), in an amount sufficient to inhibit the cellular response.