Patent ID: 7589077

Claim:
A method of treating a viral infection caused by a Hepatitis B (HBV) virus in a mammal, the method comprising administering to the mammal in need thereof, a therapeutically effective amount of a compound of formula 1A: wherein: X is ═O, ═S, N═CH—N(CH 3 ) 2 , hydroxyl, alkoxy, thiol, acyloxy, amino, substituted amino, aminoacyl, or aminoacyloxy; X 1 is O or S; X 2 is ═O, ═S, hydroxyl, thiol, alkoxy, amino or substituted amino; Y is O, S, NH or NAc; R is H, alkyl, substituted alkyl, acyl, acylamino, or alkylcarboxyl with the provisio that R is not present when X is hydroxyl, thiol, alkoxy, amino or substituted amino; R 1 is H, halogen, linear or branched, unsubstituted or substituted C 1 -C 6 alkyl, alkoxy, substituted alkoxy, hydroxyl, amino, substituted amino, aminoacyl, thiol, thioalkoxy, carboxy, alkylcarboxyl, acylamino, acyl, aryl, alkaryl, nitro, cyano, thiocyano, azido, —CH 2 OCHO or formyl; R 2 is H, —OH, —OAc, OMe or halogen; R 3 is H; and Z-Z 1 is selected from the groups consisting of CR 4 R 5 —CR 6 R 7 , (wherein R 4 , R 5 , R 6 , and R 7 are independently selected from H, OH, halogens, cyano, N 3 , CH 2 OH, COOH, C 1 -C 4 alkyl substituted carboxy, NH 2 , CH 2 NH 2 , CH 2 COOH, C 1 -C 3 thioalkyl, thiol, ONO 2 , ONH 2 , CF 3 , CNS, NHCN, CH 2 N 3 , NH—(C 1 -C 4 -alkyl), CHO, C═CH, C 1 -C 4 alkoxy, or OCH 2 aryl), CH═CH, O—CH 2 , or C(R 27 )═C(R 28 ) (wherein R 27 and R 28 are, independently of each other, selected from H, OH, halogen, or azido).