Patent ID: 7615532

Claim:
An insulin derivative which is a naturally occurring insulin or an analogue thereof which has a side chain attached to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula: -W-X—Y-Z wherein W is: an α-amino acid residue having a carboxylic acid group in the side chain which amino acid is selected from the group consisting of α-Asp, β-Asp, α-Glu, γ-Glu, α-hGlu and δ-hGlu and which residue forms, with one of its carboxylic acid groups, an amide group together with the α-amino group of the N-terminal amino acid residue of the B chain or together with the ε-amino group of a Lys residue present in the B chain of the parent insulin; X is: —CO—; Y is: —(CH 2 ) m — where m is an integer in the range of 6 to 32; Z is: —COOH; and any Zn 2+ complexes thereof.