Patent ID: 8802663

Claim:
A compound of formula (I): wherein R 1 is R 2 is selected from the following groups: R 3 is Ar 2 , Het 1 , Cyc, A, CH 3 , or S—(C 1 -C 6 -alkyl); A is a branched or linear alkyl having 2 to 12 C-atoms, wherein one or more H-atoms may be replaced by Hal, OR 4 , CN, CO 2 R 4 , or CF 3 ; cycloalkyl having 3 to 7 ring carbon atoms; Ar 2 , or N(R 4 ) 2 and wherein one or more non-adjacent CH 2 -groups may be replaced by O, NR 4 , —CO—, NR 4 CO 2 —, —CO 2 —, —NR 4 CONR 4 —, —CH═CH—, —C≡C—, or A is cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms, or A is Het 2 ; Z is a branched or linear alkyl having 2 to 12 C-atoms, wherein one or more H-atoms are replaced by Hal, OR 4 , CN, CO 2 R 4 , CF 3 , cycloalkyl having 3 to 7 ring carbon atoms, Ar 2 , N(R 4 ) 2 and/or wherein one or more CH 2 -groups are replaced by O, NR 4 , S, —CO—, NR 4 CO 2 —, —NR 4 CONR 4 —, —CH═CH—, —C≡C—, or Z is cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms; Hal is F, Cl, Br or I; Ar 2 is a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted, monosubstituted, disubstituted or trisubstituted by substituents selected from Z, F, Br, I, —OR 4 , —(CH 2 )OR 4 , —(CH 2 )N(R 4 ) 2 , Perfluoro-alkoxy, —SO 2 R 4 , —CN, —NO 2 , —N(R 4 ) 2 , —CO(NR 4 ) 2 , (NR 4 )COR 4 , —CO 2 R 4 , —COR 4 , —SO 2 N(R 4 ) 2 , —SO 2 alkyl, NR 4 SO 2 (C 1 -C 6 )alkyl, —(CH 2 ) n Het 1 , —OHet 1 , or CF 3 ; Het 1 is a monocyclic saturated, unsaturated or aromatic heterocyclic ring or a bicyclic, saturated, or unsaturated heterocyclic ring having 1 to 4 N, O and/or S atoms which may be unsubstituted, monosubstituted, disubstituted or trisubstituted by substituents selected from A, Hal, —OR 4 , —(CH 2 )OR 4 , Perfluoro-alkyl, Perfluoro-alkoxy, —SO 2 (R 4 ) 2 , CN, NO 2 , —N(R 4 ) 2 , —CO(NR 4 ) 2 , (NR 4 )COR 4 , —CO 2 R 4 , —COR 4 , —SO 2 N(R 4 ) 2 , —SO 2 alkyl, NR 4 SO 2 alkyl, NR 4 SO 2 alkyl, or C 1 -C 6 alkyl; Cyc is a saturated or unsaturated carbocyclic ring containing 3 to 7 carbon atoms which may be substituted by Hal, A, (C 1 -C 6 )alkyl, [C(R 4 ) 2 ] n -cycloalkyl, OR 4 , CF 3 , OCF 3 , N(R 4 ) 2 , NR 4 CON(R 4 ) 2 , NO 2 , CN, —[C(R 4 ) 2 ] n —COOR 4 , —[C(R 4 ) 2 ] n —CON(R 4 ) 2 , NR 4 COA, NR 4 SO 2 A, COR 4 , SO 2 N(R 4 ) 2 , SOA, and/or SO 2 A; R 4 is H, A, Cyc or (C 1 -C 6 )alkyl; n is 0, 1, 2, 3 or 4; and pharmaceutically acceptable solvates, tautomers, salts and stereo-isomers thereof.