Patent ID: 8620410

Claim:
A system comprising: a visible light source to illuminate an open surgical field of a subject's body exposed during an open surgical procedure, the visible light source providing a range of wavelengths including one or more wavelengths of visible light; a first excitation light source to illuminate the open surgical field, the excitation light source providing a first excitation wavelength that is not one of the one or more wavelengths of visible light; a second excitation light source to illuminate the open surgical field, the second excitation light source providing a second excitation wavelength that is not one of the one or more wavelengths of visible light, the second excitation wavelength being different from the first excitation wavelength; a lens disposed outside of the subject's body so as to receive at least a portion of reflected visible light from the open surgical field and at least a portion of a first and second emission wavelength from the open surgical field, the reflected visible light and the first and second emission wavelength propagating through free space outside of the subject's body from the open surgical field to the lens; a first fluorescent substance introduced into a circulatory system of the subject, the fluorescent substance being soluble in blood carried by the circulatory system and the fluorescent substance emitting photons at the first emission wavelength in response to the excitation wavelength; a second fluorescent substance introduced into a circulatory system of the subject, the second substance adapted for preferential uptake at a region of interest within the subject, and the second fluorescent substance emitting photons at the second emission wavelength in response to the second excitation wavelength; at least one electronic imaging device disposed outside of the subject's body that captures an image of a field of view that includes some portion of the open surgical procedure and the circulatory system of the subject, the image including a first image obtained from the one or more wavelengths of visible light, a second image obtained from the emission wavelength, and a third image obtained from the second emission wavelength, wherein the positioning of lens and the at least one electronic imaging device outsider of the subject's body permitting performance of the open surgical procedure on the surgical field that includes at least an opening on an exterior surface of the subject's body where an open surgical procedure is being performed and, concurrently, illuminate the surgical field by the one or more wavelengths of visible light and the at least one wavelength outside the range of wavelengths of the visible light; and a display that renders the first image, the second image, and the third image.