Patent ID: 8652475

Claim:
A fusion protein comprising: a) an antibody or antigen-binding fragment thereof that selectively binds to factor B, wherein the antibody or antigen-binding fragment thereof prevents formation of a C3bBb complex, and wherein the antibody or antigen binding fragment thereof selectively binds to factor B at the same epitope as the anti-factor B monoclonal antibody 1379 (produced by ATCC Deposit No. PTA-6230); and b) a targeting moiety comprising a CR2 protein comprising at least the short consensus repeat 1 (SCR1) and short consensus repeat 2 (SCR2) domains, C3, C3d, C3dg, iC3b, C3b, or an antibody that selectively binds to the CR2 protein, C3, C3d, C3dg, iC3b, or C3b.