Patent ID: 7378503

Claim:
An isolated antibody, wherein said antibody comprises: a) an antibody heavy chain comprising amino acids 31 to 35 of SEQ ID NO:1 for CDR1, amino acids 50 to 66 of SEQ ID NO:1 for CDR2, and amino acids 98 to 108 of SEQ ID NO:1 for CDR3, wherein amino acid 31 can be asparagine or serine, amino acid 66 can be glycine or can be deleted, and amino acid 104 can be glutamic acid or aspartic acid; and b) an antibody light chain comprising amino acids 18 to 34 or 24 to 34 of SEQ ID NO:2 for CDR1, amino acids 50 to 56 of SEQ ID NO:2 for CDR2, and amino acids 89 to 98 of SEQ ID NO:2 for CDR3, wherein amino acid 96 can be proline or isoleucine, and amino acid 98 can be phenylalanine or can be deleted, and wherein the antibody binds to insulin growth factor receptor I (IGF-IR) and inhibits the binding of insulin like growth factor I (IGF-I) and insulin like growth factor II (IGF-II) to IGF-IR.