Patent ID: 7968118

Claim:
A process for preparing an anti-acid pharmaceutical composition in powder form CHARACTERIZED in that the process comprises: a) mixing in a granulator a soluble anti-acid agent or combination of anti-acids together with mannitol, a proton pump inhibitor and 20 to 30% of the total sodium alginate until the mixture is homogeneous at room temperature so as to produce mixture a) consisting of a soluble anti-acid agent or combination of anti-acids, mannitol, proton pump inhibitor and internal sodium alginate, wherein the internal sodium alginate has a humidity of 8 to 15%; b) impregnating the mixture a) above with water in the granulator then adding a total weight of water of less than 10% of the total weight of the total composition so as to produce a mixture b) comprising mixture a) and water; c) drying the thus obtained mixture b) at normal pressure in a fluid bed, or under vacuum at a temperature of less than 50° C. until the residual humidity is less than 2% so as to produce a mixture c) consisting of mixture b), wherein mixture c) consists of less than 2% humidity; d) drying the rest of the total sodium alginate of the composition at 70° C. under vacuum until a residual humidity of less than 2% so as to produce dried sodium alginate; e) incorporating the dried sodium alginate and other ingredients of the formula to mixture c), sieving at a humidity of less than 2% and mixing for 30 minutes so as to produce a mixture e) consisting of mixture c), external sodium alginate and other ingredients, wherein mixture e) consists of less than 2% humidity; f) checking and/or further drying so that the residual humidity of mixture e) is between 0.5 and 1.5% so as to produce a mixture f) with a residual humidity of between 0.5 and 1.5%; and g) dosing and packaging mixture f), wherein the composition comprises internal sodium alginate, external sodium alginate, an anti-acid soluble agent, a combination of anti-acids and a proton pump inhibitor.