Patent ID: 7709611

Claim:
An isolated antibody or immunologically functional fragment thereof, comprising: (a) the following three light chain (LC) complementary determining regions (CDRs): (i) a LC CDR1 comprising the amino acid sequence of SEQ ID NO:70; (ii) a LC CDR2 comprising the amino acid sequence of SEQ ID NO:72; and (iii) a LC CDR3 comprising the amino acid sequence of SEQ ID NO:74; and (b) the following three heavy chain (HC) CDRs: (i) a HC CDR1 with comprising the amino acid sequence of SEQ ID NO:76; (ii) a HC CDR2 comprising the amino acid sequence of SEQ ID NO:78; and (iii) a HC CDR3 comprising the amino acid sequence of SEQ ID NO:80, wherein the antibody or immunologically functional fragment thereof can specifically bind a Dkk-1 polypeptide consisting of amino acids 32-266 of SEQ ID NO:2 or amino acids 32 272 of SEQ ID NO:4.