Patent ID: 7705002

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W is halo, OR′, SR′, N(R′) 2 , CHF 2 , or CH 2 F; R 1 and R 2 , taken together with the nitrogen atom to which they are bound, form an optionally substituted 3-8-membered monocyclic, saturated or partially unsaturated ring having 0-3 additional heteroatoms independently selected from nitrogen, sulfur, or oxygen; wherein the ring formed by R 1 and R 2 taken together, are each optionally and independently substituted at one or more substitutable carbon, nitrogen, or sulfur atoms with z independent occurrences of —R 4 , wherein z is 0-5; y is 0-5; each occurrence of R 3a , R 3b , R 3c , R 3d , R 4 , and R 5 is independently Q-R X ; wherein Q is a bond or is a C 1 -C 6 alkylidene chain wherein up to two non-adjacent methylene units of Q are optionally and independently replaced by —NR—, —S—, —O—, —CS—, —CO 2 —, —OCO—, —CO—, —COCO—, —CONR—, —NRCO—, —NRCO 2 —, —SO 2 NR—, —NRSO 2 —, —CONRNR—, —NRCONR—,—OCONR—, —NRNR—, —NRSO 2 NR—, —SO—, —SO 2 —, —PO—, —PO 2 —, —OP(O)(OR)—, or —POR—; and each occurrence of R X is independently selected from —R′, halogen, —NO 2 , —CN, —OR′, —SR′, —N(R′) 2 , —NR′COR′, —NR′CON(R′) 2 , —NR′CO 2 R′, —COR′, —CO 2 R′, —OCOR′, —CON(R′) 2 , —OCON(R′) 2 , —SOR′, —SO 2 R′, —SO 2 N(R′) 2 , —NR′SO 2 R′, —NR′SO 2 N(R′) 2 , —COCOR′, —COCH 2 COR′, —OP(O)(OR′) 2 , —P(O)(OR′) 2 , —OP(O) 2 OR′, —P(O) 2 OR′, —PO(R′) 2 , or —OPO(R′) 2 ; each occurrence of R is independently hydrogen or an optionally substituted C 1-6 aliphatic group; each occurrence of R′ is independently hydrogen or an optionally substituted C 1-6 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or R and R′, two occurrences of R, or two occurrences of R′, are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; provided that: i) when W is —OMe, then R 1 and R 2 taken together is not: wherein K is methyl or ethyl, and k is 1 or 2; ii) when W is —OH or —OAc, R 3d is Me, R 5 is 5-methyl, and each of R 3a , R 3b , and R 3c is hydrogen, then R 1 and R 2 taken together is not piperidyl or pyrrolidinyl; and when W is CF 3 or CH 2 F, then R 3d is not chloro.