Patent ID: 8586006

Claim:
A method for detecting an abnormal prostate state in a subject comprising, a) contacting a blood sample from the subject with a panel of at least four detection reagents wherein each detection reagent is specific for one prostate-specific protein; wherein the prostate-specific proteins are selected from the prostate-specific protein set as follows; SEQ Gene Protein ID ID NO Description ANXA8*& NP_001621 384 annexin A8 CAV1& NP_001744 1351 caveolin 1 CLCA2* NP_006527 59346 calcium activated chloride channel 2 COL17A1* NP_000485 59347 alpha 1 type XVII collagen H2BFS NP_059141 65564 H2B histone family, member S HIST1H2BC NP_003517 65565 H2B histone family, member L HIST1H2BD& NP_066407 14604 H2B histone family, member B HIST1H2BE NP_003514 65566 H2B histone family, member H HIST1H2BJ NP_066402 65567 H2B histone family, member R HIST1H2BM NP_003512 65568 H2B histone family, member E HIST1H2BN NP_003511 65569 H2B histone family, member D HIST1H2BO NP_003518 65570 histone H2B HNT*& NP_057606 4329 neurotrimin IL1A* NP_000566 59357 interleukin 1, alpha proprotein KRT6A*& NP_005545 6225 keratin 6A KRT6B*& NP_005546 17263 keratin 6B KRT6C*& NP_490596 6226 keratin 6C LAMA3* NP_000218 59362 laminin alpha 3 subunit isoform 2 LAMA3* NP_937762 59363 laminin alpha 3 subunit isoform 1 LAMB3* NP_000219 59364 laminin subunit beta 3 precursor LAMB3* NP_001017402 59365 laminin subunit beta 3 precursor LOC653107* XP_931601 65577 PREDICTED: similar to Annexin A8 (Annexin VIII) (Vascular anticoagulant-beta) (VAC-beta) isoform 1 LOC653107* XP_936422 65578 PREDICTED: similar to Annexin A8 (Annexin VIII) (Vascular anticoagulant-beta) (VAC-beta) isoform 2 LOC653107* XP_936471 65585 PREDICTED: similar to Annexin A8 (Annexin VIII) (Vascular anticoagulant-beta) (VAC-beta) isoform 10 LOC653107* XP_936481 65587 PREDICTED: similar to Annexin A8 (Annexin VIII) (Vascular anticoagulant-beta) (VAC-beta) isoform 12 LOC653107* XP_936484 65588 PREDICTED: similar to Annexin A8 (Annexin VIII) (Vascular anticoagulant-beta) (VAC-beta) isoform 13 LOC653107* XP_936492 65589 PREDICTED: similar to Annexin A8 (Annexin VIII) (Vascular anticoagulant-beta) (VAC-beta) isoform 14 MASP1*& NP_624302 14670 mannan-binding lectin serine protease 1 isoform 2 precursor S100A2& NP_005969 30938 S100 calcium binding protein A2 SCRN3* NP_078859 65605 secernin 3 SEMA3C* NP_006370 65606 semaphorin 3C SEPT11*& NP_060713 4577 septin 11 SERPINB5* NP_002630 59403 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 SFN* NP_006133 59405 stratifin b) measuring the amount of prostate-specific protein detected in the blood sample by each detection reagent; and c) comparing the amount of prostate-specific protein detected in the blood sample by each detection reagent to a predetermined normal control amount for each respective prostate-specific protein; wherein a statistically significant altered level in said prostate-specific proteins indicates a perturbation in the normal biological state.