Patent ID: 8071582

Claim:
A method for treating a subject at risk of or suffering from a fungal infection, the method comprising administering to the subject a composition comprising a therapeutically effective amount of the compound having the structure of Formula I: wherein, n is 0, 1, or 2; R 1 and R 2 together with the nitrogen atom to which they are attached form a 4- to 8-membered heterocycloalkyl or heterocycloalkenyl group each of which is optionally substituted with 1 or 2 independently selected R x groups; Ar is selected from phenyl, naphthyl, and a monocylic or bicyclic heteroaryl group, each of which is optionally substituted with 1 or 2 independently selected R x groups, or with a phenyl, O-phenyl, or OCH 2 -phenyl in which the phenyl group of each is optionally substituted with 1 or 2 independently selected R x groups; R 3 is L 1 -L 2 -R 4 , where L 1 is selected from a bond, O, NR 1 , and S; L 2 is selected from a bond, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl, (C 1 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 1 -C 6 )heteroalkenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 3 -C 8 )heterocycloalkyl, and (C 3 -C 8 )heterocycloalkenyl; and R 4 is selected from H, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl each of which is optionally substituted with 1 or 2 independently selected R x groups; R x is L s1 L s2 R s , wherein each L s1 and L s2 is independently selected from a bond, â€”Oâ€”, â€”C(â•O)â€”, â€”Sâ€”, â€”S(â•O)â€”, â€”S(â•O) 2 â€”, â€”NHâ€”, â€”NHC(O)â€”, â€”C(O)NHâ€”, S(â•O) 2 NHâ€”, â€”NHS(â•O) 2 , â€”OC(O)NHâ€”, â€”NHC(O)Oâ€”, (C 1 -C 6 ) alkyl, and â€”(C 2 -C 6 ) alkenyl; and R s is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, aryloxy, mercapto, alkylthio, arylthio, alkylsulfoxide, arylsulfoxide, alkylsulfone, arylsulfone, cyano, halo, isocyanato, thiocyanato, isothiocyanato, nitro, perhaloalkyl, perfluoroalkyl, silyl, and amino, including mono- and di-substituted amino groups; or a pharmaceutically acceptable salt, thereof.