Patent ID: 8329208

Claim:
A composition comprising a physiologically effective amount of S-adenosylmethionine (SAMe), wherein non-parenteral administration of said composition to a selected human subject group produces in said selected human subject group an effect comprising at least one of an average maximum SAMe blood plasma concentration (average C max ) of at least about 100 ng/mL per each 100 mg dosage of SAMe ion delivered, or an average SAMe plasma area under the curve (average AUC) of at least 450 ng·h/mL per each 100 mg dosage of SAMe ion delivered; wherein said composition is in a dosage form comprising a functional coating of from 1 to 5% of the total weight of said dosage form, and wherein said dosage form provides about 25-80% release of SAMe after 45-75 minutes of being in an aqueous solution having an initial pH of about 6.