Patent ID: 7273885

Claim:
A compound of formula (IA): wherein: A, together with X and Y, is: a 3- to 6-membered aromatic or non-aromatic ring having up to 3 heteroatoms independently selected from N, NH, O, SO 1 or SO 2 ; wherein said ring is optionally fused to a (C6–C10)aryl, (C5–C10)heteroaryl, (C3–C10)cycloalkyl, or (C3–C10)heterocyclyl; wherein A has up to 3 substituents selected independently from J; J is halogen, —OR′, —NO 2 , —CF 3 , —OCF 3 , —R′, oxo, —OR′, —O-benzyl, —O-phenyl, 1,2-methylenedioxy, —N(R′) 2 , —SR′, —SOR′, —SO 2 R′, —C(O)R′, —COOR′ or —CON(R′) 2 , wherein R′ is independently selected from: hydrogen, (C1–C12)-aliphatic, (C3–C10)-cycloalkyl or -cycloalkenyl, [(C3–C10)-cycloalkyl or -cycloalkenyl]-(C1–C12)-aliphatic, (C6–C10)-aryl, (C6–C10)-aryl-(C1–C12)aliphatic, (C3–C10)-heterocyclyl, (C6–C10)-heterocyclyl-(C1–C12)aliphatic, (C5–C10)-heteroaryl, or (C5–C10)-heteroaryl-(C1–C12)-aliphatic; R 1 and R 3 are independently: (C1–C12)-aliphatic, (C3–C10)-cycloalkyl or -cycloalkenyl, [(C3–C10)-cycloalkyl or -cycloalkenyl]-(C1–C12)-aliphatic, (C6–C10)-aryl, (C6–C10)-aryl-(C1–C12)aliphatic, (C3–C10)-heterocyclyl, (C6–C10)-heterocyclyl-(C1–C12)aliphatic, (C5–C10)-heteroaryl, or (C5–C10)-heteroaryl-(C1–C12)-aliphatic, wherein each of R 1 and R 3 is independently and optionally substituted with up to 3 substituents independently selected from J; wherein up to 3 aliphatic carbon atoms in R 1 and R 3 may be replaced by a heteroatom selected from O, NH, S, SO, or SO 2 in a chemically stable arrangement; R 2 and R 4 are independently hydrogen, (C1–C12)-aliphatic, (C3–C10)-cycloalkyl-(C1–C12)-aliphatic, or (C6–C10)aryl-(C1–C12)-aliphatic, wherein each of R 2 and R 4 is independently and optionally substituted with up to 3 substituents independently selected from J; wherein up to two aliphatic carbon atoms in R 2 and R 4 may be replaced by a heteroatom selected from O, NH, S, SO, or SO 2 ; R 5 is (C1–C12)-aliphatic, wherein any hydrogen is optionally replaced with halogen, and wherein any hydrogen or halogen atom bound to any terminal carbon atom of R 5 is optionally substituted with sulfhydryl or hydroxy; W is selected from: wherein each R 6 is independently: hydrogen, (C1–C12)-aliphatic, (C6–C10)-aryl, (C6–C10)-aryl-(C1–C12)aliphatic, (C3–C10)-cycloalkyl or -cycloalkenyl, [(C3-C10)-cycloalkyl or -cycloalkenyl]-(C1–C12)-aliphatic, (C3–C10)-heterocyclyl, (C3–C10)-heterocyclyl-(C1–C12)-aliphatic, (C5–C10)heteroaryl, or (C5–C10)heteroaryl-(C1–C12)-aliphatic, or two R 6 groups, which are bound to the same nitrogen atom, form together with that nitrogen atom, a (C3–C10)-heterocyclic ring; wherein R 6 is optionally substituted with up to 3 J substituents; V is —C(O)N(R 8 )—, —S(O)N(R 8 )—, or —S(O) 2 N(R 8 )—; wherein R 8 is hydrogen or (C1–C12)-aliphatic; T is selected from: (C5)-heterocyclyl, (C5)-heterocyclyl-(C1–C12)-aliphatic, (C5)heteroaryl, or (C5)heteroaryl-(C1–C12)-aliphatic; wherein each T is optionally substituted with up to 3 J substituents.