Patent ID: 8207161

Claim:
A compound of formula (II): or a pharmaceutically acceptable salt thereof, wherein: Ar is phenyl, either unsubstituted or substituted with 1 to 5 substituents independently selected from the group consisting of halogen, cyano, hydroxyl, alkyl or alkoxyl, wherein the alkyl or alkoxyl is each independently unsubstituted or substituted with one or more halogens; R 1 is selected from the group consisting of hydrogen, alkyl, trifluoromethyl, cycloalkyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, aryl or heteroaryl is each independently either unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, cyano, aryl, hydroxyl and amino; R 2 is selected from the group consisting of hydroxyl, amino, alkyl, alkoxyl, cycloalkyl, heterocyclic alkyl, aryl, heteroaryl and —NR 4 R 5 , wherein the alkyl, alkoxyl, cycloalkyl, heterocyclic alkyl, aryl or heteroaryl is each independently either unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, amino, cyano, hydroxyl, alkyl, cycloalkyl, alkoxyl, aryl, heteroaryl, —NR 4 R 5 , —OC(O)OR 8 , carboxylic acid and carboxylic ester; R 3 is selected from the group consisting of hydrogen and alkyl; R 4 and R 5 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclic alkyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclic alkyl, aryl or heteroaryl is each independently either unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, hydroxyl, amino, alkoxyl, alkyl, cyano, aryl, cycloalkyl, heterocyclic alkyl, heterocyclic aryl, hydroxyalkyl, —SO 2 R 7 , —NR 4 R 5 , carboxylic acid and carboxylic ester; or R 4 and R 5 , together with the nitrogen to which they are attached, form a 4 to 8 membered heterocycle, wherein the 4 to 8 membered heterocycle contains one or more N, O, S atoms, and the 4 to 8 membered heterocycle is either unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, hydroxyl, amino, alkoxyl, alkyl, cyano, aryl, heterocyclic alkyl, heteroaryl, carbonyl, hydroxyalkyl, —SO 2 R 7 , —NR 4 R 5 , —C(O)NR 4 R 5 , —C(O)R 7 , ═O, carboxylic acid and carboxylic ester; R 7 is alkyl; and R 8 is selected from the group consisting of alkyl and cycloalkyl.