Patent ID: 8796280

Claim:
A pharmaceutical composition which inhibits chemoattractant receptor-homologous molecule expressed on T-helper 2 cell activity comprising a pharmaceutically acceptable carrier, diluent or excipient and a compound according to Formula (I), or stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein: A is selected from the group consisting of: where n is 0, 1, 2, 3 or 4; m is 2; B is selected from the group consisting of phenyl or piperazinyl; R 1 is hydrogen; R 2 is phenyl, wherein R 2 is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, C 1 -C 6 -alkyl; R 3 is selected from the group consisting of C 1 -C 6 -alkyl, aryl, heteroaryl, C 1 -C 6 -alkylaryl, C 1 -C 6 -alkylheteroaryl, C 3 -C 8 -cycloalkyl and C 3 -C 8 -heterocycloalkyl wherein each of said C 1 -C 6 -alkyl, aryl, heteroaryl, C 1 -C 6 -alkylaryl, C 1 -C 6 -alkylheteroaryl, C 3 -C 8 -cycloalkyl and C 3 -C 8 -heterocycloalkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, heteroaryl, aryl, thioalkoxy and thioalkyl, or wherein said aryl, heteroaryl, C 1 -C 6 -alkylaryl, C 1 -C 6 -alkylheteroaryl, C 3 -C 8 -cycloalkyl or C 3 -C 8 -heterocycloalkyl may be fused to one or more aryl, heteroaryl, C 3 -C 8 -cycloalkyl or C 3 -C 8 -heterocycloalkyl groups and may be substituted with one or more substituents selected of the group consisting of C 1 -C 6 -alkyl, alkoxy, aryl, heteroaryl, carboxyl, cyano, halogen, hydroxy, amino, aminocarbonyl, nitro, sulfoxy, sulfonyl, sulfonamide and trihaloalkyl; R 7 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl, heteroaryl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -heterocycloalkyl, carboxy, cyano, amino and hydroxy; the aryl is selected from phenyl or naphthyl; and the heteroaryl is selected from pyridyl, indolyl, benzimidazolyl and quinolyl.