Patent ID: 7037913

Claim:
A compound of Formula I, including pharmaceutically acceptable salts thereof, A is phenyl or heteroaryl; wherein said heteroaryl is a monocyclic ring and is comprised of 5 to 6 atoms selected from the group consisting of C, N, NR 9 , O, and S; and wherein each ring of said phenyl and heteroaryl is optionally substituted with one bromo, fluoro, or methyl group; W is O; T is Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; Z 5 is CR 5 or N; Z 6 is CR 6 or N; Z 7 is CR 7 or N; Z 8 is CR 8 or N; wherein one and not more than one of Z 1 through Z 8 is N; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently selected from the group consisting of a bond, hydrogen, halogen, cyano, nitro, X′R 24 , C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 4-7 cycloalkenyl, C 2-6 alkynyl, aryl, heteroaryl, heteroalicyclic, C(O)NR 28 R 29 , COR 25 and CO 2 R 25 ; wherein said C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 4-7 cycloalkenyl, C 2-6 alkynyl, aryl, heteroaryl, and heteroalicyclic are optionally substituted with one to nine same or different halogens or from one to five same or different substituents selected from the substituents comprising group F; m is 1; p is 1; F is selected from the group consisting of C 1-6 alkyl, hydroxy, C 1-6 alkoxy, cyano, halogen, benzyl, N-amido, NR 30 R 31 , C 1-6 alkylC(O)NR 30 R 31 , C(O)NR 30 R 31 , COOR 32 and C 1-6 alkylCOOR 32 ; R 9 is selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, cyano, and fluoro; R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 and R 18 are each independently selected from the group consisting of hydrogen and methyl; X′ is selected from the group consisting of NR 10 , O, and S; R 24 is hydrogen or C 1-6 alkyl; R 25 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl and heteroaryl; R 28 and R 29 are each independently selected from the group consisting of hydrogen, SO 2 C 1-6 alkyl, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, heteroaryl, and heteroalicyclic wherein said C 1-6 alkyl, C 3-7 cycloalkyl, aryl, heteroaryl, and heteroalicyclic are optionally substituted with one to nine same or different halogens or C 1-6 alkyl groups; R 30 and R 31 are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, wherein said C 1-6 alkyl, C 3-7 cycloalkyl, and aryl are optionally substituted with one to nine same or different halogens; R 32 is selected from the group consisting of hydrogen, C 1-6 alkyl, and C 3-7 cycloalkyl; provided that at any given time only one of the members selected from the group consisting of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 is a bond, and further provided that said bond is the point of attachment to the adjacent carbon atom in the compound of Formula I.