Patent ID: 7276029

Claim:
A method for calibrating a substantially continuous analyte sensor, the method comprising: receiving a data stream from an analyte sensor, including one or more sensor data points; receiving reference data from a reference analyte monitor, comprising one or more reference data points; providing at least one matched data pair by matching reference analyte data to substantially time corresponding sensor data; creating a conversion function based on said at least one matched data pair; evaluating said at least one matched data pair, including at least one of 1) ensuring said at least one matched data pair is within a predetermined time range, 2) ensuring said at least one matched data pair is no older than a predetermined value, 3) ensuring said at least one matched data pair is substantially distributed with additional matched data pairs, if present, between high and low matched data pairs over a predetermined time range, and 4) ensuring said at least one matched data pair is within a predetermined range of analyte values, wherein the step of evaluating said at least one matched data pair further comprises at least one of evaluating a rate of change of the analyte concentration, evaluating a congruence of respective sensor and reference data in a matched data pair, and evaluating physiological changes; and subsequently modifying said conversion function if such modification is required by said evaluation.