Patent ID: 7037504

Claim:
A modified EGF polypeptide composition comprising an amino acid sequence of length X, X being an integer that is at least 48 and not more than 53, such sequence (i) being at least 75% identical to that of positions 1-47 of SEQ ID NO: 1, and (ii) having at position X an amino acid residue different from that found in SEQ ID NO: 1, wherein the composition comprises a biological activity that is at least 50% of that of the polypeptide whose sequence is shown in SEQ ID NO: 1, the activity being selected from the group consisting of mitogenesis, cell growth stimulation, tissue growth stimulation, cytoprotection, inhibition of acid secretion, migration stimulation, wound healing, growth of a tissue precursor cell, differentiation of a tissue precursor cell, growth and differentiation of a tissue precursor cell, and EGF receptor binding.