Patent ID: 6878842

Claim:
Process for synthesizing organic compounds of R configuration of general formula (I): in which: R 1 represents a hydrogen atom, an alkyl radical containing from 1 to 6 carbon atoms, an aryl radical, a halogen atom or a radical —OR 3 , R 3 having the meaning given below, R 2 represents a hydrogen atom or an alkyl radical containing from 1 to 6 carbon atoms, R 3 represents a hydrogen atom or an alkyl radical containing from 1 to 6 carbon atoms, said process being characterized in that it comprises the following steps: a) placing a compound of formula (II): in contact with an effective amount of lipase in the presence of an acylating agent and a solvent to obtain a mixture of corresponding R acetate and S alcohol, b) treating the mixture of R acetate and S alcohol with a dialkyl azodicarboxylate in the presence of trialkyl or triaryl phosphines and a nucleophilic compound so as to convert the alcohol into R acetate by inversion of configuration, c) obtaining the corresponding R alcohol by transesterification, in the presence of methanol and sodium carbonate, followed by a crystallization, and then d) coupling the alcohol thus obtained with the compound of formula (III): in which: X represents a halogen atom, R 1 has the same meaning as above, R 2 represents a hydrogen atom or an alkyl radical containing from 1 to 6 carbon atoms, in this latter case, the ester possibly undergoing a saponification reaction to give the compound of formula (I) with R 2 ═H.