Patent ID: 7125863

Claim:
A compound selected from compounds of formula 1, tautomers and stereoisomers, diastereoisomers, enantiomers and epimers thereof, and pharmaceutically acceptable salts of said compounds, tautomers, stereoisomers, diastereoisomers, enantiomers and epimers, wherein: R 1 is either a hydrogen atom or a nitrile group; X 1 is selected from a sulphur atom, an oxygen atom, a sulphonyl group and a methylene group; X 2 is a carbonyl group, a methylene group or a covalent bond; Het is an aromatic nitrogen-containing heterocycle selected from pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl and benz-fused analogues thereof, all of which may optionally be substituted on one or more carbon atoms, and where the substituents are selected from C 1 –C 6 alkyl, hydroxy, C 1 –C 6 alkyloxy, amino, C 1 –C 6 alkylamino, di(C 1 –C 6 alkyl)amino, fluoro, chloro, bromo, trifluoromethyl, nitro, cyano, carboxy and C 1 –C 6 alkyloxycarbonyl groups; and n is 1–5.