Patent ID: 6846834

Claim:
A compound having the formula: wherein W is N; X is CH; Y is selected from the group consisting of O, S and N(R); wherein R is selected from the group consisting of H, CN, NO 2 , (C 1 -C 10 )alkyl, (C 3 -C 10 )cycloalkyl, (C 4 -C 10 )cycloalkyl-alkyl, (C 3 -C 10 )alkenyl and (C 2 -C 10 )alkynyl; Z is selected from the group consisting of H, (C 1 -C 10 )alkyl, (C 3 -C 10 )cycloalkyl, (C 4 -C 10 )cycloalkyl-alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl and NR 2 R 3 ; R 1 , R 2 and R 3 are independently selected from the group consisting of H, (C 1 -C 10 )alkyl, (C 3 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 1 -C 10 )heteroalkyl, (C 3 -C 10 )cycloalkyl, (C 4 -C 10 )cycloalkyl-alkyl, (C 3 -C 10 )cycloheteroalkyl-alkyl, (C 3 -C 10 )cycloheteroalkyl, aryl, aryl(C 1 -C 4 )alkyl, aryl(C 1 -C 4 )heteroalkyl, heteroaryl(C 1 -C 4 )alkyl, heteroaryl(C 1 -C 4 )heteroalkyl and perfluoro(C 1 -C 6 )alkyl; and wherein when Z is NR 2 R 3 , R 2 and R 3 can be combined to form a 5- to 7-membered heterocyclyl ring; R 4 is selected from the group consisting of H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 4 -C 7 )cycloalkyl-alkyl, (C 2 -C 6 )alkenyl and (C 2 -C 6 )alkynyl; A is a substituted or unsubstituted 6-membered fused carbocyclic or heterocyclic aromatic ring system, wherein the heterocyclic aromatic ring system contains 1-2 N atoms; and B is a substituted or unsubstituted five- or six-membered ring which is aromatic, containing at least one nitrogen atom, and from 0 to 3 additional heteroatoms, wherein the B ring substituents are selected from the group consisting of halogen, CF 3 , CF 3 O, (C 1 -C 6 )alkyl, perfluoro(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )heteroalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )thioalkoxy, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, (C 3 -C 10 )cycloalkyl, (C 4 -C 10 )cycloalkyl-alkyl, (C 3 -C 10 )cycloheteroalkyl, cyano, nitro, sulfonamido, (C 1 -C 6 )acyl, (C 1 -C 6 )acylamino, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, carboxamido and (C 1 -C 6 )heteroalkoxyl; or pharmaceutically acceptable salts thereof.