Patent ID: 8048857

Claim:
A composition for promoting bone formation comprising: an effective amount of a biological factor; and a flowable carrier slurry having a viscosity of about 1×10 8 centipoises and comprising a biocompatible fluid, a biodegradable polymer consisting of soluble collagen and insoluble collagen, a carbodiimide, and a calcium phosphate compound, the calcium phosphate compound being granules having average pore sizes of 0.1 to 25 microns and the granules having diameters of 100 to 1600 microns, wherein the volume ratio of the biocompatible fluid to the biodegradable polymer and calcium phosphate compound is between about 1:1 to 1:4 and the ratio of the biodegradable polymer to the calcium phosphate is between 75:25 and 50:50 by weight and the biological factor is released over 7 to 21 days and the calcium phosphate compound comprises 15% hydroxyapatite uniformly distributed through 85% beta-tricalcium phosphate.