Patent ID: 7947835

Claim:
A compound of Formula 2: or a pharmaceutically acceptable salt thereof or a mixture thereof, wherein R is chosen from optionally substituted cycloalkyl, optionally substituted aryl and optionally substituted heteroaryl; M is chosen from a covalent bond and —CH═CH—. Q is chosen from wherein R 10 and R 11 are independently chosen from hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; and R 12 , R 13 , R 14 , and R 15 are each independently chosen from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, phenyl, substituted phenyl chosen from mono-, di-, and tri-substituted phenyl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroalkyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl), heteroaryl, and substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroalkyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl); and Z is chosen from optionally substituted phenylene and optionally substituted pyridylidene; W-D is which is optionally substituted with a group chosen from hydroxy, cyano, halo, optionally substituted lower alkyl, and optionally substituted lower alkoxy; R 16 is chosen from hydrogen, cyano, optionally substituted cycloalkyl, and optionally substituted lower alkyl; and D is a hydrogen bond donor other than hydrogen.