Patent ID: 7226906

Claim:
A cyclosporin analog having the Formula I or a pharmaceutically acceptable salt thereof, wherein: residue A has the formula R 1 is V, W, Y and T are independently selected from H, F, Br, Cl, alkyl, Z n -cycloalkyl, Z n -heterocycloalkyl, Z n -SH, Z n -S-alkyl, Z n -S-heterocycloalkyl, Z n -SA r , Z n -S-Z n R 5 , —O-Z n -heterocycloalkyl, O-Z n -R 5 , Z n -OH, Z n -O-alkyl, Z n -O-heterocycloalkyl, Z n -OA r , Z n -NR 2 R 3 , Z n -CN, and —O—CHR y C(═O)OR x , wherein said alkyl, cycloalkyl, heterocycloalkyl and A r portions are optionally substituted with one or more groups independently selected from oxo (provided it is not on said A r ), alkyl, F, Cl, Br, O-alkyl, OA r and Z n C(═O)alkyl; X is selected from and D is O, S, —CH 2 —, —CH 2 O—, —CH 2 S—, or —CH 2 CH 2 —; R a , R b , R c , R d , R e , and R f are independently H, F, Br, Cl, alkyl, Z n -O-alkyl, or Z n -OA r ; R j is H or alkyl; R x is H, alkyl or CH 2 A r ; R y is H, alkyl or A r ; R 2 and R 3 are independently H, alkyl, Z n -A r , or Z n -O-alkyl, wherein said alkyl and A r portions are optionally substituted with one or more groups independently selected from F, Cl, Br and I; A r is a fully unsaturated, a partially unsaturated, or fully saturated carbocyclic or heterocyclic ring, wherein said carbocyclic and heterocyclic rings are optionally substituted with one or more groups independently selected from F, Cl, Br, I, CN, CF 3 , CHF 2 , CH 2 F, OH, O-alkyl, alkoxyaryl, —OC(═O)R 7 , C(═O)OR 7 and —SC(═O)R 7 ; Z is alkylene having from 1 to 4 carbons, or alkenylene or alkynylene each having from 2 to 4 carbons, wherein said alkylene, alkenylene, and alkynylene are optionally substituted with one or more groups independently selected from alkyl, OH, O-alkyl, NR 7 R 8 , and alkyl-NR 7 R 8 ; R 4 , R 5 and R 6 are independently H, C 1 –C 7 alkyl, alkoxyalkyl, —CO 2 H or —C(═O)Oalkyl; R 7 and R 8 are independently H, alkyl, alkenyl, or alkynyl; residue B is -αABu-, -Val-, -Thr-, or NVa-; residue U is -(D)Ala-, (-D)Ser-, —[O-(2-hydroxyethyl)(D)Ser]-, —[O-acyl(D)Ser] or —[O-(2-acyloxyethyl)(D)Ser]-; and n is 0, 1, 2, 3, or 4.