Patent ID: 7816330

Claim:
A method for treating diabetes or Syndrome X, or associated symptoms or complications thereof in a subject, comprising (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor of formula (III) wherein: X is CH, N, or C═O; R 1 is H or absent; R 2 is H, F, Cl, OCH 3 , OCH 2 CH 3 , or C 1-4 alkyl, CF 3 , SCH 3 , substituted or unsubstituted phenyl or NR 3 R 4 ; R 3 and R 4 are H, C 1 -C 6 alkyl, or taken together with the nitrogen atom to which they are both attached form a 5-6 membered heterocyclyl with optionally 1-2 additional heteroatoms independently selected from O, S, and N; Q is —(CH 2 ) n — where n is 1 or 2; P is H, C 1-7 acyl, or (C 1-6 alkoxy)carbonyl; and Z is substituted or unsubstituted, and is selected from C 3-7 cycloalkyl, phenyl, 5- or 6-membered heteroaryl having 1 or 2 heteroatoms independently selected from N, O, and S, a biaryl, and a 9- or 10-membered fused bicyclyl or fused heterobicyclyl, wherein said fused heterobicyclyl has between 1 and 4 heteroatoms independently selected from N, O, and S; or a pharmaceutically acceptable salt thereof; (b) administering to said subject a jointly effective amount of a second antidiabetic agent, and (c) administering to said subject a jointly effective amount of a third antidiabetic agent; said co-administration being in any order and the combined jointly effective amounts providing the desired therapeutic effect.