Patent ID: 7723331

Claim:
A compound of formula I wherein: X—Y—Z represents N═CH—N; R 1 represents Cl, Br, F, C 1-3 alkyl (optionally substituted with one or more F), or alkoxy (optionally substituted with one or more F); A represents a group —C(R 2 ) 2 —[(CR 3 ) 2 ] m —, wherein R 2 and R 3 , independently, represent H or C 1-3 alkyl, and wherein m is 0 or 1; B represents phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, thiazolyl, or thiophenyl, each optionally substituted by one or more cyano, halo, C 1-3 alkyl (optionally substituted with OH, OMe and/or with one or more of F), or C 1-3 alkoxy (optionally substituted with one or more F or with OMe); D represents a bond, —(CH 2 ) n —, where n is 1 or 2, or —O(CH 2 ) p —, where p is 0 to 2; E represents one of the following: wherein: R 4 represents H or C 1-5 alkyl, substituted with one or more F, OH, OCHF 2 or OCF 3 ; R 5 and R 6 , independently, represent H, C 1-5 alkyl, or C 3-6 cycloalkyl, or R 5 and R 6 , together with the nitrogen to which they are attached, form a 5 or 6 membered ring optionally containing another nitrogen or oxygen atom; q is 0 or 1; and R 7 represents C 1-3 alkyl optionally substituted with one or more OH; or a tautomer, optical isomer, or racemate thereof, as well as a pharmaceutically acceptable salt thereof.