Patent ID: 7217692

Claim:
A method of identifying an agent that modulates the formation of a FOXC2 protein complex, the method comprising: (i) contacting a first polypeptide comprising the amino acid sequence of SEQ ID NO:1 and a second polypeptide comprising the amino acid sequence of SEQ ID NO:2, 3, 4, 5, 6, or 7, in the presence of a candidate agent; (ii) measuring the formation of a complex between the first polypeptide and the second polypeptide in the presence of the candidate agent; and (iii) comparing the formation of the complex between the first polypeptide and the second polypeptide in the presence of the candidate agent with the formation of a complex between the first polypeptide and the second polypeptide in the absence of the candidate agent, to thereby determine whether the candidate agent modulates the formation of a FOXC2 protein complex.