Patent ID: 6846928

Claim:
A compound of formula I: or a pharmaceutically acceptable derivative thereof, wherein: Y is CR 2 ; R 2 is R, oxo, halogen, —CN, —NO 2 , —CO 2 R, —Ar, -T-Ar, or -T-R; X is sulfur; each occurrence of R is independently hydrogen, an optionally substituted C 1-6 aliphatic group, or Ar; Z 1 is CR x ; R x is —R, halogen, —N(R) 2 , —NO 2 , —CN, —CO 2 R, —OR, or —SR; wherein two R bound to the same nitrogen atom may be taken together with that nitrogen atom to form a five or six membered heterocyclic or heteroaryl ring having one to two additional heteratoms independently selected from oxygen, nitrogen, or sulfur; Z 2 is CR y ; R y is —R 1 , —CN, halogen, —NO 2 , —Ar, -T-Ar, or -T-R; R 1 is hydrogen or an optionally substituted C 1-6 aliphatic group; each Ar is independently an optionally substituted 3-6 membered heterocyclic ring having one or two heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a 5 or 6 membered aryl ring having zero to three heteroatoms independently selected from nitrogen, oxygen, or sulfur; T is a C 1-4 alkylidene chain wherein one methylene unit of T is optionally replaced by —O—, —S—, —C(O)—, —CO 2 —, —NR—, —NRC(O)—, —NRC(O)NR—, —C(O)C(O)—, —OC(O)NR—, —NRCO 2 —, —SO 2 NR—, —NRSO 2 —, or —NRSO 2 NR—; Q is a valence bond; and Ring D is a six membered optionally substituted monocyclic aryl ring.