Patent ID: 6933124

Claim:
A method for screening compounds for modulation of GABA B receptor 1 transcription, comprising the steps of: (a) providing an isolated host cell that has been transfected with an expression system comprising a nucleic acid molecule comprising: a promoter element selected from the group consisting of: (i) a nucleic acid molecule comprising SEQ ID NO: 1, (ii) a nucleic acid molecule at least 95% homologous to SEQ ID NO: 1, (iii) a nucleic acid molecule comprising SEQ ID NO: 2, and (iv) a nucleic acid molecule at least 95% homologous to SEQ ID NO: 2; and a reporter gene, wherein the promoter element is coupled to the reporter gene so that expression of the reporter gene is under the control of the promoter element; (b) contacting a test compound with the cell; and (c) determining whether the test compound modulates the level of expression of the reporter gene, wherein modulation of reporter gene expression is indicative of the ability of the test compound to modulate GABA B receptor 1 transcription.