Patent ID: 8293911

Claim:
A compound of formula IA wherein R 1 and R 2 , vary independently, and are selected from the group consisting of H, CN, halogen, CH 2 CN, OH, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , C 1 -C 6 alkyl, C(═O)C 1 -C 6 alkyl; NH—C 1 -C 6 alkyl; N(C 1 -C 6 alkyl)-C 1 -C 6 alkyl, NHC(═O)C 1 -C 6 alkyl, C(═O)N(CH 3 ) 2 , C(═O)N(Et) 2 , C(═O)NH 2 , C(═O)NH—C 1 -C 6 alkyl, SO 2 NH 2 , NHSO 2 —C 1 -C 6 alkyl; C(═O)OC 1 -C 6 alkyl, OC(═O)C 1 -C 6 alkyl, OC 1 -C 6 alkyl, SC 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, (CH 2 ) m C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl, (CH 2 ) m C 3 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Ar, (CH 2 ) m thienyl, (CH 2 ) m imidazolyl, (CH 2 ) m pyrazyl, (CH 2 ) m oxazolyl, (CH 2 ) m isoxazolyl, (CH 2 ) m thiazolyl, (CH 2 ) m isothiazolyl, (CH 2 ) m phenyl, (CH 2 ) m pyrrolyl, (CH 2 ) m pyridyl, and (CH 2 ) m pyrimidyl, wherein m=zero, 1, or 2; Ar is a 5- to 10-member mono- or bicyclic aromatic group, optionally containing 1-4 ring heteroatoms selected independently from N, O, and S; or R 1 and R 2 , together with the ring carbon atoms to which they are attached, form a 5- or 6-member fused ring; wherein said fused ring may be saturated, unsaturated, or aromatic, and said fused ring optionally contains one or two heteroatoms selected independently from the group consisting of O, N, and S; R′ is selected from the group consisting of H, halogen, phenyl, 2-(N,N-dimethylamino)ethyl, CF 3 , OC 1 -C 3 alkyl and C 1 -C 3 alkyl; R 3 and R 4 vary independently, and are selected from the group consisting of H, CN, halogen, CF 3 , OCF 3 , OC 1 -C 3 alkyl, and C 1 -C 3 alkyl; X is O or S; Y is O or S; q=1 or zero; and R 5 is selected from the group consisting of C 1 -C 6 alkyl, (CHR 6 ) w C 3 -C 6 cycloalkyl, (CHR 6 ) w CH 2 C 3 -C 6 cycloalkyl, CH 2 (CHR 6 ) w C 3 -C 6 cycloalkyl, CR 6 ═CH—C 3 -C 6 cycloalkyl, CH═CR 6 —C 3 -C 6 cycloalkyl, (CHR 6 ) w C 5 -C 6 cycloalkenyl, CH 2 (CHR 6 ) w C 5 -C 6 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Ar, (CHR 6 ) w Ar, CH 2 (CHR 6 ) w Ar, and (CHR 6 ) w CH 2 Ar, wherein w=zero, 1, 2, or 3; Ar is a 5- to 10-member mono- or bicyclic aromatic group, optionally containing 1-4 ring heteroatoms selected independently from the group consisting of N, O, and S; and R 6 is selected from the group consisting of H or C 1 -C 3 alkyl; where all cycloalkyl and cycloalkenyl optionally contain one or two ring heteroatoms selected independently from N, O, and S; wherein all alkyl, cycloalkyl, alkenyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, alkynyl, aryl, and heteroaryl groups in R 1 , R 2 , R′, R 3 , R 4 , R 5 , R 6 , and Ar are optionally substituted with one or two substituents selected independently from the group consisting of C 1 -C 3 alkyl, halogen, OH, OEt, OMe, CN, CH 2 F, OCF 3 , and CF 3 ; and wherein, additionally, all cycloalkyl and heterocycloalkyl groups are optionally substituted with a carbonyl group.