Patent ID: 6998419

Claim:
A method for treating a mammal with an inflammation-related condition selected from the group consisting of psoriatic arthritis, inflammatory bowel disease (IBD), septic shock, erythema nodosum leprosy, septicemia, uveitis, adult respiratory distress syndrome (ARDS), organ rejection, neuro-inflammatory conditions, and cardio-inflammatory conditions which method comprises administering to said mammal a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective inflammation-reducing amount of a compound of formula I: wherein R 1 is selected from the group consisting of: each R 2 is independently selected from a group of the formula: R 3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl; R 4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl and aryl; R 5 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R 6 and R 7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; or R 6 and R 7 can be joined to form an alkylene or substituted alkylene group having from 2 to 10 carbon atoms; R 8 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; R 9 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl and substituted cycloalkenyl; or R 8 and R 9 can be joined to form an alkylene or substituted alkylene group having from 2 to 10 carbon atoms; R 10 selected from the group consisting of hydrogen, 1 to 6 carbon alkyl and 3 to 6 carbon cycloalkyl; or R 1 and R 10 can be joined to form an alkylene, substituted alkylene, —C(O)—S(O)— or —S(O) 2 — group; R 11 and R 12 are independently selected from the group consisting of 1 to 6 carbon alkyl and 3 to 6 carbon cycloalkyl; or R 11 and R 12 can be joined to form an alkylene group having from 2 to 10 carbon atoms; X is oxygen, sulfur, —S(O)— or —S(O) 2 —; and W is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof.