Patent ID: 7196090

Claim:
A compound of the formula: wherein: A is O, NH 2 , NH(C 1 –C 6 alkyl), N(C 1 –C 6 alkyl) 2 , or —NHC(O)—NHR 12 ; R 12 is C 1 –C 6 straight or branched chain alkyl, or —(CH 2 )n-C 3 –C 8 cycloalkyl ring; n is an integer of from 1 to 3; B is N, C is CH, D is N, R 1 is selected from the group of C 1 –C 6 straight or branched chain alkyl, optionally substituted by —COOH, or; a) a phenyl, benzyl or C 3 –C 8 cycloalkyl ring, or —CH 2 —C 3 –C 8 cycloalkyl ring, with the phenyl, benzyl or cycloalkyl rings being optionally substituted by 1 or 2 COOH or —CH 2 —COOH groups; or b) a piperidine or piperazine moiety selected from group of: the rings of the piperidine or piperazine moieties being optionally substituted by 1 or 2 COOH or —CH 2 —COOH groups; or c) a tetrahydropyran or morpholine moiety of the formulae: R 2 is H, Cl or F; R 3 is H, Cl or F, with the proviso that at least one of R 2 or R 3 is F; R 4 is H, OH, —OCH 3 , or —OCH 2 CH 3 , with the proviso that, if R 4 is H, R 2 and R 3 are not H; R 5 is —OCH 3 , or —OCH 2 CH 3 ; R 6 is selected from the group of H, —(C 1 –C 5 alkyl)-NH 2 , —(C 1 –C 5 alkyl)-NH—(C 1 –C 3 alkyl)-R 11 , —(C 1 –C 5 alkyl)-N—(C 1 –C 3 alkyl-R 11 ) 2 , —O—(C 1 –C 5 alkyl)-NH 2 , —O—(C 1 –C 5 alkyl)-NH—(C 1 –C 3 alkyl)-R 11 , —O—(C 1 –C 5 alkyl)-N—(C 1 –C 3 alkyl-R 11 ) 2 , —CH(CH 2 OH) 2 , —(C 1 –C 3 alkyl)-(CH 2 OH) 2 , —(C 1 –C 3 alkyl)-O—(C 1 –C 3 alkyl)-R 11 , —(C 1 -C 3 alkyl)-O—(C 1 –C 3 alkyl)-NH 2 , —(C 1 –C 3 alkyl)-O—(C 1 –C 3 alkyl)-NH—(C 1 –C 3 alkyl)-R 11 , —(C 1 –C 3 alkyl)-O—(C 1 –C 3 alkyl)-N(C 1 –C 3 alkyl-R 11 ) 2 , phenyl substituted by one or two groups selected from NH 2 , —N(C 1 –C 3 alkyl), —N(C 1 –C 3 alkyl) 2 , CN or —(C 1 –C 3 alkyl)-tetrazole, or C 1 –C 6 alkyl, with each of the alkyl chains of any group in this R 4 definition being optionally substituted by from 1 to 4 OH groups; R 7 in each instance is independently selected from H, —NH 2 , NH(C 1 –C 3 alkyl), N(C 1 –C 3 alkyl) 2 , or C 1 –C 3 alkyl; R 8 is H, OH or C 1 –C 3 alkyl; R 9 is H, OH, —NH 2 , NH(C 1 –C 3 alkyl), or N(C 1 –C 3 alkyl) 2 ; R 10 is H or C 1 –C 3 alkyl; R 11 is H, CN, OH, NH 2 , F, or CF 3 ; or a pharmaceutically acceptable salt or ester form thereof.