Patent ID: 7067512

Claim:
A compound of Formula I: or pharmaceutically acceptable salt thereof; wherein: X and Y are independently —C(O)—, —CH 2 — or —C(S)—; R 1 , R 3 , and R 4 are independently hydrogen, halo, alkyl, alkenyl, alkynyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, cyano, amino, alkanoylamino, nitro, hydroxy, carboxy, or alkoxycarbonyl; or R 3 and R 4 are taken together to form —(CH 2 ) u —, where u is 3–6, —CH═CH—CH═CH— or —CH 2 CH═CHCH 2 —; R 2 is hydrogen, halo, C 1-4 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, acetylamino, C 1-6 alkoxy, phenyl, halophenyl, hydroxyphenyl, C 1-6 alkoxyphenyl, C 1-6 alkylphenyl, aminophenyl, C 1-6 alkylenedioxyphenyl, hydroxycarbonylphenyl, thienyl, C 1-6 alkylthienyl, furanyl, pyrrolyl, amino, C 1-6 hydroxyalkyl or cyano; R 5 is hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonylalkyl, alkylaminocarbonyl or alkylaminocarbonylalkyl; R 6 is cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; R 7 and R 8 are independently hydrogen or alkyl; R 9 is cycloalkyl, aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkyl(alkyl), aralkyl or heteroarylalkyl, each of which is optionally substituted; and R 10 is —(CH 2 ) n —CO 2 R b , —(CH 2 ) m —CO 2 M, —(CH 2 ) i —OH or —(CH 2 ) j —CONR c R d where R b is hydrogen, alkyl, optionally substituted cycloalkyl, or optionally substituted, saturated or partially unsaturated heterocycle; M is a cation; R c and R d are independently hydrogen, alkyl, hydroxyalkyl, carboxyalkyl, aminoalkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, and an optionally substituted, saturated or partially unsaturated heterocycle; and n is 0–8, m is 0–8, i is 1–8 and j is 0–8.