Patent ID: 6867011

Claim:
Biepitope compound consisting of formula I: Ξ-E 1 -Z-E 2 -Ψ (I) in which: E 1 and E2, which are identical or different, represent a peptide sequence comprising a minimum epitope of troponin I, Z represents a chain of formula II: —NH—(CH 2 ) m —CO— (II) in which m represents an integer from 1 to 10, or a mixed construct of formulae III to V: -[pep 1 -NH—(CH 2 ) m —CO] p - (III) -[pep 1 -NH—(CH 2 ) m —CO-pep 2 ] p - (IV) -[NH—(CH 2 ) m —CO-pep2] p - (V) in which m represents an integer from 1 to 10, p represents an integer from 1 to 5, and pep 1 and pep 2 which are identical or different, represent a peptide chain containing from 2 to 10 amino acids forming an extended epitope of troponin I with the sequences E 1 an E 2 , respectively, Ξ represents a hydrogen atom, an acetyl group, a peptide sequence of 1 to 10 amino acids, an N-α-acetylated peptide sequence of 1 to 10 amino acids, a cysteinyl, biotinyl or biocytinyl group, a peptide sequence of 1 to 10 amino acids carrying a cysteinyl, biotinyl or biocytinyl residue, a linear or branched amino(C 1 -C 10 alkyl)carbonyl chain, an N-α-acetylated linear or branched amino(C 1 -C 10 alkyl)carbonyl chain, a mixed construct of at least one peptide sequence of 1 to 10 amino acids and at least one linear or branched amino(C 1 -C 10 alkyl)carbonyl chain, or a mixed construct of at least one peptide sequence of 10 to 10 amino acids and at least one linear or branched amino(C 1 -C 10 alkyl)carbonyl chain carrying a cysteinyl, biotinyl, or biocytinyl residue, Ψ represents a hydroxyl radical, an amino radical, a peptide sequence of 1 to 10 amino acids, or a peptide sequence of 1 to 10 amino acids carrying an amino-terminal group, a linear or branched amino(C 1 -C 10 alkyl)carbonyl chain, a linear or branched amino(C 1 -C 10 alkyl)carbonyl chain carrying a hydroxyl radical or an amino radical, a mixed construct of at least one peptide sequence of 1 to 10 amino acids and at least one linear or branched amino(C 1 -C 10 alkyl)carbonyl chain, or a mixed construct of at least one peptide sequence of 1 to 10 amino acids and at least one linear or branched amino(C 1 -C 10 alkyl)carbonyl chain carrying a hydroxyl radical or an amino radical.