Patent ID: 7772177

Claim:
A compound of Formula 1.2a, wherein: n is 0 or 1; m is 0, 1, or 2; Y is NH, O or S; R 1 and R 1a are independently 1) H, or 2) C 1 -C 6 alkyl optionally substituted with one R 6 substituent; R 2 is 1) H, or 2) C 1 -C 6 alkyl optionally substituted with one or more halogens; R 3 is 1) H, or 2) C 1 -C 6 alkyl optionally substituted with one R 6 substituent; R 4 and R 5 are each independently 1) H, 2) C 1 -C 6 alkyl, 3) aryl, 4) heteroaryl, 5) —C(═Y)NR 8 R 9 , 6) C 1 -C 6 alkyl-O n C(O)—, 7) haloalkyl-O n C(O)—, 8) C 3 -C 7 cycloalkyl-O n C(O)—, 9) aryl-O n C(O)—, 10) heteroaryl-O n C(O)—, 11) heterocyclyl-O n C(O)—, 12) C 3 -C 7 cycloalkyl-S(O) 2 —, 13) aryl-S(O) 2 —, 14) heteroaryl-S(O) 2 —, 15) heterocycyl-S(O) 2 —, 16) C 1 -C 7 cycloalkyl, or 17) heterocyclyl; wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents; wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; R 6 is: 1) halogen, 2) haloalkyl, 3) C 1 -C 6 alkyl, 4) C 3 -C 7 cycloalkyl, 5) aryl, 6) heteroaryl, 7) heterocyclyl, 8) —OR 7 , 9) —S(O) m R 7 , 10) —NR 8 R 9 , 11) —COR 7 , 12) —C(O)OR 7 13) —OC(O)R 7 , 14) —SC(O)R 7 , 15) —CONR 8 R 9 , 16) —S(O) 2 NR 8 R 9 , or 17) —N C (═Y)NR 8 R 9 wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; R 7 is: 1) H, 2) haloalkyl, 3) C 1 -C 6 alkyl, 4) C 3 -C 7 cycloalkyl, 5) aryl, 6) heteroaryl, 7) heterocyclyl, or 8) R 8 R 9 NC(═Y)—, wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents, and the aryl, heteroaryl, and heterocyclyl, are optionally substituted with one or more R 10 substituents; R 8 and R 9 are each independently 1) H, 2) haloalkyl, 3) C 1 -C 6 alkyl, 4) C 3 -C 7 cycloalkyl, 5) aryl, 6) heteroaryl, 7) heterocyclyl, 8) —C(O)R 11 , 9) —C(O)YR 11 , or 10) —SO 2 R 11 , wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents, and wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; or R 8 and R 9 together with the nitrogen atom to which they are bonded form a five, six, or seven membered heterocyclic ring optionally substituted with one or more R 6 substituents; R 10 is 1) halogen, 2) NO 2 , 3) CN, 4) C 1 -C 6 alkyl, 5) C 3 -C 7 cycloalkyl, 6) haloalkyl, 7) —OR 7 , 8) —NR 8 R 9 , 9) —SR 7 , 10) —COR 7 , 11) —C(O)OR 7 , 12) —S(O) m R 7 , 13) —CONR 8 R 9 , or 14) —SO 2 NR 8 R 9 , wherein the alkyl is optionally substituted with one or more R 6 substituents; and R 11 is 1) C 1 -C 6 alkyl, 2) C 3 -C 7 cycloalkyl, 3) aryl, 4) heteroaryl, or 5) heterocyclyl, wherein the alkyl and cycloalkyl are optionally substituted with one or more R 6 substituents; and wherein the aryl, heteroaryl, and heterocyclyl are optionally substituted with one or more R 10 substituents; or a salt thereof.