Patent ID: 7582609

Claim:
A method for preventing or treating a fibrotic disease or complications thereof on the skin of a subject comprising topically applying to the skin of the subject a composition comprising (a) a peptide that inhibits TGFβ1, said peptide being selected from the group consisting of: i) SEQ ID NO: 1 or SEQ ID NO: 2 or a fragment of SEQ ID NO: 1 or SEQ ID NO: 2 having at least 6 amino acids; ii) a peptide that comprises at least six consecutive amino acids from peptide SEQ ID NO: 1 or SEQ ID NO: 2; and iii) a peptide having more than 75% homology with the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2; said peptide having a molecular weight ranging from 700 to 3,000 Daltons; and a solubility value in a range from 3 to −9; and (b) a topical vehicle for administration of the peptide, such that the peptide diffuses through the epidermal barrier of the skin of the subject for local inhibition of TGFβ1 without systemic absorption of the peptide.