Patent ID: 7816397

Claim:
A compound of the formula (1): wherein: B and E are both each a —CH 2 — group or are both each an oxygen atom; R1 is: H, or (C 1 -C 8 )alkyl which is optionally substituted by one or more groups chosen independently from halogen, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 3 -C 8 )cycloalkyl and (C 6 -C 14 )aryl R2 and R2′ are each: H; R3 is: H, or (C 1 -C 20 )alkyl; R4 is: R5 is Z; D is a single bond or a (C 1 -C 6 )alkyl group; A is a single bond; Z is in each case: (C 1 -C 20 )alkyl which is optionally substituted by one or more groups X; (C 2 -C 20 )alkene which is optionally substituted by one or more groups X; (C 2 -C 20 )alkyne which is optionally substituted by one or more groups X; (C 6 -C 14 )aryl, (C 6 -C 14 )aryl(C 1 -C 5 )alkoxy, (C 6 -C 14 )aryloxy or (C 6 -C 14 )aryloxy(C 1 -C 5 )alkoxy, the aryl group of each of these groups being optionally substituted by one or more groups X; —(C 3 -C 8 )cycloalkyl which is optionally substituted by one or more groups X; (C 3 -C 8 )heterocycle comprising one or more hetero atoms chosen from N, O and S and which is optionally substituted by one or more groups X; (C 6 -C 14 )aryl(C 1 -C 20 )alkyl, (C 6 -C 14 )aryl(C 2 -C 20 )alkene or (C 6 -C 14 )aryl-(C 2 -C 20 )alkyne, the aryl group of each of these groups being optionally substituted by one or more groups X; (C 5 -C 13 )heteroaryl and (C 5 -C 13 )heteroaryl(C 1 -C 20 )alkyl comprising one or more hetero atoms chosen from N, O and S, the heteroaryl group of each of these groups being optionally substituted by one or more groups X; (C 3 -C 8 )cycloalkyl(C 1 -C 20 )alkyl, (C 3 -C 8 )cycloalkyl(C 2 -C 20 )alkene or (C 3 -C 8 )cycloalkyl(C 2 -C 20 )alkyne, the cycloalkyl group of each of these groups being optionally substituted by one or more groups X; X is in each case amino, hydroxyl, thio, halogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, carboxyl, carboxymethyl or carboxyethyl, (C 1 -C 8 )alkyl, (C 1 -C 8 )-alkoxy, (C 1 -C 8 )alkylthio, (C 1 -C 8 )alkylamino, (C 6 -C 14 )aryl, (C 6 -C 14 )arykl(C 1 -C 8 )-sulfonylalkyl, (C 6 -C 14 )aryloxy, (C 6 -C 14 )aryl(C 1 -C 8 )alkoxy, —NHCO(C 1 -C 8 )alkyl, —N—(C 1 -C 8 )alkylCO(C 1 -C 8 )alkyl, —CO(C 1 -C 8 )alkyl, —SO 2 (C 6 -C 14 )aryl, di(C 1 -C 8 )alkylamino, (C 3 -C 8 )cycloalkyl or a ketone function; n and n′ are each independently 1, 2 or 3, or a tautomeric form, enantiomer, diastereoisomer or epimer thereof, or a pharmaceutically acceptable salt thereof.