Patent ID: 8586320

Claim:
A method for treating a human subject being prognosed for gastrointestinal cancer recurrence, the method comprising: a) determining the amount of tyrosine phosphorylated Shc (PY-Shc) and/or p66-Shc present in a biological sample derived from said subject; and b) comparing said amount to a control amount of tyrosine phosphorylated Shc (PY-Shc) and/or p66-Shc present in a control sample, wherein said p66-Shc is Shc adaptor protein of SEQ ID NO:4, and PY-Shc is p66-Shc with a tyrosine residue phosphorylated at one of positions 349, 350 or 427 of SEQ ID NO:4, wherein a control amount of tyrosine phosphorylated Shc (PY-Shc) and/or p66-Shc in a cell or a sample is derived from a subject not afflicted with cancer, and wherein a decreased amount of tyrosine phosphorylated Shc (PY-Shc) or an increased amount of p66-Shc in said sample relative to the amount in the control sample indicates that the gastrointestinal cancer will recur in said subject, and an increased amount of tyrosine phosphorylated Shc (PY-Shc) or a decreased amount of p66-Shc in said sample relative to the amount in the control sample indicates that the gastrointestinal cancer will not recur in said subject, thereby the prognosed cancer recurrence in the subject will be treated.