Patent ID: 7354921

Claim:
A method of treating breast cancer, comprising administering to a mammal an amount of a first compound, or a pharmaceutically acceptable salt, thereof; and an amount of at least one second compound; wherein the amounts of the first compound and said second compound result in a therapeutic effect, further wherein said first compound is represented by the structural formula: wherein: R 1 is selected from the group consisting of H, alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR 6 R 7 , cycloalkyl and cycloalkylalkyl, wherein each of said alkyl, aryl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl and arylalkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, heterocyclyl, trifluoromethyl, OR 6 , NR 6 R 7 , SR 6 , SO 2 R 6 , CN, SO 2 N(R 6 R 7 ) and NO 2 ; R 2 is alkyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, â€”OR 7 , â€”SR 7 , hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or -alkylene-N(R 8 R 9 ) (where R 8 and R 9 independently represent H or alkyl, or R 8 and R 9 taken together with the nitrogen in â€”N(R 8 R 9 ) form a five- to seven-membered heterocycle); R 3 is â€”NR 4 R 5 , alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl; R 4 is alkyl, cycloalkyl or heterocyclyl, wherein each of said alkyl, cycloalkyl and heterocyclyl can be unsubstituted or optionally independently substituted with 1-4 substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, alkyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, trifluoromethyl, OR 6 , NR 6 R 7 , SR 6 , SO 2 R 6 , CN, SO 2 N(R6R7) and NO 2 ; R 5 is H, alkyl, aryl, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl or heteroarylalkyl; R 6 is H, alkyl or aryl; R 7 is H or alkyl; R 10 is halo, alkyl, hydroxyalkyl, trifluoromethyl, OR 6 , NR 6 R 7 , SR 6 , SO 2 R 6 , CN, SO 2 N(R 6 R 7 ) or NO 2 ; and n is 0 to 4, and when n is 2-4, the n moieties can be the same or different, each being independently selected, with the following provisos: (i) that when R 2 is C 1 -C 4 alkyl and R 5 is H, then R 4 is not a C 1 -C 4 alkyl; (ii) that when R 2 is halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or -alkylene-N(R 8 R 9 ), then: (a) R 3 is not H, alkylthio, aralkylthio, alkylsulfinyl, aralkylsulfinyl, or â€”NR 4 R 5 , and (b) n is not 0; and (iii) that when R 2 is alkyl, cycloalkyl, alkenyl or alkynyl, then R 3 is not NH(methyl), N,N(dimethyl), NH(acetyl), N(methyl)(acetyl), H, alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl.