Patent ID: 8784816

Claim:
An isolated monoclonal antibody directed against factor VIII which is partially inhibiting factor VIII procoagulant activity, wherein said antibody is comprising: heavy chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 33, 34 and 35, respectively, and light chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 36, 37 and 38, respectively; or heavy chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 39, 40 and 41, respectively, and light chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 42, 43 and 44, respectively; or an antigen-binding fragment of any of said antibodies.