Patent ID: 7198787

Claim:
Method to kill breast cancer cells expressing EGP2 and MUC1 antigens in a cell population selected from the group consisting of cells comprising nucleated cells in peripheral blood and bone marrow cells comprising CD-34 + cells selected from the above nucleated cells, the method comprising: incubating the cell population with a combination of two or more immunotoxins, wherein each immunotoxin comprises a conjugate between an antibody or antigen binding fragment thereof and a cell toxin or active toxin fragments, or a recombinantly produced antibody or antigen binding antibody fragments, further comprising toxins or active toxin fragments, wherein the antibodies or antigen binding fragment thereof are directed to epitopes on the antigen EGP2 expressed by the gene GA733-2 and to epitopes on the antigen expressed by the MUC1 gene and the toxin is Pseudomonas exotoxin A, wherein the antibodies are selected from the group consisting of MOC31, BM2, antibodies binding to the same epitopes as MOC31 or BM2, or antigen binding fragments thereof.