Patent ID: 8283340

Claim:
A compound of formula (I): or pharmaceutically acceptable salt, ester, amide or solvate thereof, wherein: X 1 is such that —X 1 —X 2 is —O—X 2 , —S—X 2 , —SO 2 —O—X 2 , —SO 2 NZ 10 —X 2 , conjugated alkenemethyloxy or conjugated alkenemethylthio, conjugated alkenemethylSO 2 —O, conjugated alkenemethyl-SO 2 NZ 10 or of the formula: —X 2 is absent or is such that X 1 —X 2 -Effector is one of each n and m is independently 0 or 1; p is 0, 1 or 2; X 3 is oxygen or sulfur and additionally, when m=0, may be SO 2 —O, SO 2 NZ 10 , conjugated alkenemethyloxy, conjugated alkenemethylthio, conjugated alkenemethyl-SO 2 —O or conjugated alkenemethyl-SO 2 NZ 10 each of Y 1 , Y 2 and Y 3 is carbon; Y 4 is oxygen, sulfur, sulfoxide or sulfone; —Y 5 — is a single bond; each of Z 1 -Z 4 , where present, are independently selected from hydrogen , alkyl, alkenyl, alkynyl, aryl, aralkyl, alkyloxy, alkenyloxy, alkynyloxy, aryloxy, aralkyloxy, alkylthioxy, alkenylthioxy, alkynylthioxy, arylthioxy, aralkylthioxy, amino, hydroxy, thio, halo, carboxy, formyl, nitro and cyano; Z 5 , where present, is independently selected from hydrogen alkyl, alkenyl, alkynyl, aryl, aralkyl, alkyloxy, alkenyloxy, alkynyloxy, aryloxy, aralkyloxy, alkylthioxy, alkenylthioxy, alkynylthioxy, arylthioxy, aralkylthioxy, amino, hydroxy, thio, carboxy, formyl, nitro and cyano; or one of Z 2 & Z 3 , Z 3 & Z 4 and Z 4 and Z 5 together with the atoms to which they are connected form an aromatic ring fused to the remainder of the compound; provided that at least one of Z 1 , Z 2 and Z 4 is hydrogen; Z 6 is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and aralkyl; none, one or two of Y 6 may be nitrogen atoms with the remainder being carbon atoms; each Z 7 is independently hydrogen, alkyl or aryl; each Z 8 is independently selected from hydrogen, an electron withdrawing group, unsubstituted C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, unsubstituted C 1 -C 6 alkoxy, and substituted C 1 -C 6 alkoxy where the substituted alkyl or alkoxy are substituted with one or more groups selected from ether, amino, mono- or di-substituted amino, cyclic C 1 -C 5 alkylamino, imidazolyl, C 1 -C 6 alkylpiperazinyl, morpholino, thiol, thioether, tetrazole, carboxylic acid, ester, amido, mono- or di-substituted amido, N-connected amide, N-connected sulfonamide, sulfoxy, sulfonate, sulfonyl, sulfoxy, sulfinate, sufinyl, phosphonooxy, phosphate and sulfonamide; each Z 9 is independently oxygen or sulfur; Z 10 is hydrogen or alkyl, for example a C 1-4 alkyl; and Effector is a molecule of formula (II); wherein: Z 12 is oxygen or sulfur; each X 4 is independently oxygen, sulfur or NZ 13 , wherein each —Z 13 is independently —(CH 2 ) 2 —Z 14 , -alkyl or -hydrogen; and each Z 14 is independently chloro, bromo, iodo or mesylate.