Patent ID: RE39592

Claim:
A solid composition for implantation into an animal comprising a first composition comprising at least one compound selected from the group consisting of a compound of the formula wherein R is loweralkyl, the ester derivatives, geometric isomers, stereoisomers, or optical isomers thereof, a compound of the formula wherein R 1 and R 2 are loweralkyl, the ester derivatives, geometric isomers, steroisomers, or optical isomers thereof, a compound of the formula wherein R 3 and R 4 are loweralkyl, the geometric isomers, stereoisomers, optical isomers thereof, a compound of the formula wherein R 5 is loweralkyl, the ester derivatives, geometric isomers, stereoisomers, or optical isomers thereof, and a compound of the formula wherein R 6 is loweralkyl, the ester derivatives, geometric isomers, stereoisomers, or optical isomers thereof; and a second composition comprising at least one compound selected from the group consisting of a compound of the formula wherein R is loweralkyl, the ester derivatives, geometric isomers, stereoisomers, or optical isomers thereof, a compound of the formula wherein R 1 and R 2 are loweralkyl, the ester derivatives, geometric isomers, stereoisomers, or optical isomers thereof, a compound of the formula Wherein R 5 is loweralkyl, the ester derivatives, geometric isomers, stereoisomers, optical isomers thereof, a compound of the formula Wherein R 3 and R 4 are loweralkyl, the geometric isomers, stereoisomers, or optical isomers thereof, and a compound of the formula Wherein R 6 is loweralkyl, the ester derivatives, geometric isomers, stereoisomers, or optical isomers thereof; and a biodegradable polymer selected from the group consisting of homopolymers and copolymers of γ-butyrolactone, δ-valerolactone, ε-caprolactone, glycolide, DL-lactide, L-lactide, glycolic acid, DL-lactic acid, L-lactic acid, and combinations thereof, polydioxanones, polyorthesters, polyanhydrides, polycarbonates, polyesteramides, and polyphosphazines, wherein the second composition is coated on its surface with the biodegradable polymer whereby the release of its comprised compound is a delayed release in an in vivo environment such that the release of the compound of the second composition is delayed until at least about 35 days after placing the composition comprising the first composition and the second composition into an in vivo environment.