Patent ID: 8865893

Claim:
A method for preparing 2-morpholinoisobornane-10-thiol, comprising the following steps: (a) providing a compound represented by formula (I), wherein each of R 1 and R 2 , independently, is C 1-6 alkyl, C 5-10 cycloalkyl, C 4-9 heterocycloalkyl, C 6-10 aryl, or C 5-9 heteroaryl, and the heterocycloalkyl and the heteroaryl have at least one heteroatom selected from the group consisting of oxygen, sulfur, and nitrogen, or R 1 and R 2 together form —(CH 2 ) x Z(CH 2 ) y —, wherein x and y is 1, 2, or 3, and Z is CH 2 , NH, O, or S; (b) converting the compound represented by formula (I) into a compound represented by formula (II), (c) reducing the compound represented by formula (II) into a compound represented by formula (III), (d) forming a compound represented by formula (IV), by N-alkylation of the compound represented by formula (III) with W 1 —(CH 2 ) 2 O(CH 2 ) 2 —W 2 , wherein W 1 and W 2 are leaving groups; and (e) reducing the compound represented by formula (IV) into 2-morpholinoisobornane-10-thiol.