Patent ID: 8415464

Claim:
A composition comprising cells and two single-copy probes that have a combined length of at least 50 kb, each labeled with a distinguishable label, for detecting a chromosomal aberration involving the BCR and ABL genes, said chromosomal aberration having an ABL gene side and a BCR gene side, wherein one of said probes hybridizes to the ABL gene side of said chromosomal aberration and comprises a region that hybridizes to the ABL gene telomeric to the 200 kb region between exons Ib and II, and the other of said probes hybridizes to the BCR gene side of said chromosomal aberration and comprises a region that hybridizes to the BCR gene centromeric to the breakpoint region, wherein the probe that hybridizes to the BCR gene side has the designation PEM12 or the probe that hybridizes to the ABL gene side has the designation c-hu-ABL; and wherein the probes are hybridized to chromosomal DNA in situ in the cells.