Patent ID: 8653299

Claim:
A compound having Formula I or a pharmaceutically acceptable salt thereof, wherein: “ ” is a single bond or a double bond; “ ” is a single bond or a double bond; R 1 is H, halogen, —S(O)R 10 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl, C 3-8 cycloalkenyl or hydroxyl; R 2 is H, halogen, —S(O)R 10 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl, C 3-8 cycloalkenyl or hydroxyl; R 3 is H, halogen, —S(O)R 10 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl or hydroxyl; R 4 is H or C(O)R 12 ; R 5 is H, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl or —C 2-6 alkynyl; R 6 is H, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl or —C 2-6 alkynyl; Y is O or S; X is O, NR, or CH 2 ; R a is C 6-10 aryl, heteroaryl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl or H; R b is bromine; c is 0, 1 or 2; R 7 is H, halogen, —S(O)R 10 , —S(O) 2 R 11 , nitro, cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkenyl or C 3-8 cycloalkyl; R 8 is H, halogen, —S(O)R 10 , —S(O) 2 R 11 , cyano, —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , NR 13 R 14 , C 3-8 cycloalkenyl or C 3-8 cycloalkyl; R 9 is H, —S(O) 2 R 11 , —OC 1-6 alkyl, —SC 1-6 alkyl, —C 1-6 alkyl, —C 2-6 alkenyl, —C 2-6 alkynyl, C(O)R 12 , C 3-8 cycloalkenyl or C 3-8 cycloalkyl; R 10 is —C 1-6 alkyl, C 3-8 cycloalkyl, or C 3-8 cycloalkenyl; R 11 is H, hydroxyl, —C 1-6 alkyl, C 3-8 cycloalkyl or C 3-8 cycloalkenyl; R 12 is H, hydroxyl, —C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, NR 13 R 14 or —OC 1-6 alkyl; R 13 is H, —C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl SO 2 R 11 or C(O)R 15 ; R 14 is H, —C 1-6 alkyl, C 3-8 cycloalkenyl, aryl, heterocycle or C 3-8 cycloalkyl; R 15 is H, —C 1-6 alkyl, C 3-8 cycloalkenyl or C 3-8 cycloalkyl; and R is H, —C 1-6 alkyl, C 3-8 cycloalkenyl or C 3-8 cycloalkyl; with the provisos when “ ” is a double bond then R 5 and R 6 are void; and the compound is not of structures