Patent ID: 8394829

Claim:
A compound of Formula I: wherein X is a substituted phenyl ring selected from: Z is a bond or a moiety selected from: R 1 is CH 2 OH, CH 2 CH 2 OH, N(H)C(O)H, or N(H)S(O 2 )C 1 -c 3 alkyl, and R 2 is H; or R 1 and R 2 together with the phenyl to which they are bound form a bicyclic, fused heterocyclic ring having 9 or 10 ring atoms wherein 1 or 2 ring atoms are selected from N, O and S, wherein said bicyclic fused heterocyclic ring is optionally substituted with one, two or three additional substituents independently selected from alkyl, oxo and OH; R 3 is selected from C 4-12 alkylene, C 4-12 alkenylene, C 4-12 alkynylene, R 8 —O—R 8 , R 8 —N(R 7 )—R 8 , C 3-6 cycloalkylene, R 8 —C 3-6 cycloalkylene, R 8 —C 3-6 cycloalkylene-Het, C 3-6 cycloalkylene-R 8 , R 8 —C 3-6 cycloalkylene-R 8 , C 6-10 arylene, R 8 —C 6-10 arylene, C 6-10 arylene-R 8 , R 8 —C 6-10 arylene-R 8 , R 8 —C 6-10 arylene-O—R 8 , R 8 — C 6-10 arylene-N(R 7 )—R 8 , R 8 —C 6-10 arylene-C 6-10 arylene, Het, R 8 -Het, Het-R 8 , R 8 -Het-R 8 , R 8 —O-Het, R 8 —C 6-10 arylene-O-Het, R 8 —C 6-10 arylene-C(O)-Het, R 8 —C 6-10 arylene-N(R 7 )-Het, R 8 -Het-C 6-10 arylene, R 8 —C 6-10 arylene-Het, and R 8 —O—R 8 —C 6-10 arylene; wherein said alkylene, alkenylene or alkynylene are each optionally substituted with 1, 2 or 3 substituents selected from halo, oxo, and OR 7 ; wherein said phenylene groups are each optionally substituted with 1, 2, 3, or 4 substituents selected from halo, alkyl, and OR 7 ; Het is 5-6 membered saturated or unsaturated monocyclic heterocyclene or an 8-10 membered saturated or unsaturated bicyclic heterocyclene wherein 1 or 2 ring atoms are selected from N, O and S, and wherein said monocyclic or bicyclic heterocyclene is optionally substituted with 1, 2 or 3 substituents selected from halo, alkyl, alkoxy, oxo and OH; Y is C(O), OC(O), C(O)N(R 7 ), C(O)N(R 7 )CH 2 , OC(O)NR 7 CH 2 , N(R 7 )C(O), or N(R 7 )C(O)N(R 7 ); a is 0, 1, 2, 3, or 4; R 4 is selected from halo, alkyl, and OR 7 ; R 5 is H or alkyl; b is 1, 2, 3, 4, or 5; R 6 is selected from halo, alkyl, haloalkyl, OR 7 , O-haloalkyl, R 8 —OR 7 , O—R 8 —OR 7 , C(O)alkyl, O—R 8 —C(O)alkyl, CON(R 7 ) 2 , R 8 —CON(R 7 ) 2 , R 8 —N(R 7 ) 2 , N(R 7 )C(O)alkyl, N(R 7 )C(O)N(R 7 ) 2 , N(R 7 )SO 2 alkyl, R 8 —SO 2 N(R 7 ) 2 , and CN; or two R 6 on adjacent carbons, together with the phenyl to which they are bound form a bicyclic heterocyclic ring having 9 or 10 ring atoms wherein 1 or 2 ring atoms are selected from N, O and S; R 7 is H or alkyl; and R 8 is C 1-10 alkylene, C 2-10 alkenylene, or C 2-10 alkynylene wherein each R 8 is optionally substituted with 1, 2 or 3 substituents selected from halo, oxo, and OR 7 ; with the proviso that the total number of carbon atoms in the C 1-10 alkylene, C 2-10 alkenylene, or C 2-10 alkynylene chains of two R 8 groups in any definition of R 3 is not greater than 12; R 9 is H or C 1 -C 3 alkyl; or a pharmaceutically acceptable salt thereof.