Patent ID: 6846681

Claim:
A silicon substrate having a silicon surface comprising a patterned covalently bound monolayer, said monolayer comprising a group of the formula: R—C≡C—Si wherein Si is a surface silicon atom through which a substituted or unsubstituted alkynyl group is bonded to the silicon surface; and R is an optionally substituted C 1 -C 18 alkyl group; and when R is a substituted group, the group is substituted with one or more substituents selected from the group consisting of hydroxy, halo, cyano, isocyano, C 2 -C 24 alkynyl, C 1 -C 18 alkoxy, C 1 C 18 carboxy, C 1 -C 18 alkoxycarbonyl, primary, secondary or tertiary amino, thiol, optionally substituted phosphino, aryl, or C 1 -C 18 alkylthioether, halo C 1 -C 18 alkyl, cyano C 1 -C 18 alkyl, isocyano-C 1 -C 18 alkyl, C 1 -C 18 carbamido, or C 1 -C 18 alkylthio group, a metal chelating ligand or a metal complex thereof, or a DNA or RNA analog capable of forming a double or triple stranded complex with DNA or RNA.