Patent ID: 7691848

Claim:
A compound having the Formula I: wherein R 1 and R 2 are selected independently from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, halogen, trifluoromethyl, hydroxyl, (C 1 -C 6 ) alkoxy, —OCF 3 , carboxy, —CONH[(C 1 -C 6 )alkyl], —CON[(C 1 -C 6 ) alkyl] 2 , amino, (C 1 -C 6 ) alkylamino and —NHCO[(C 1 -C 6 )alkyl]; R 3 is selected from the group consisting of hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, hydroxyl, amino, (C 1 -C 6 ) alkylamino, —C(O) alkyl and halogen; A is —C═O; B is selected independently from the group consisting of wherein R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are selected independently from the group consisting of hydrogen, alkyl, alkoxy, trihalomethyl, halogen, —C(O) alkyl, hydroxy, hydroxyalkyl, alkyloxyalkyl, —CH(OH)alkyl, —CH(alkoxy)alkyl, formyl, nitro, thioalkyl, —SO 2 alkyl, —SO 2 NHR 13 , —SO 2 N(R 13 ) 2 , —(CH 2 ) p CN, —(CH 2 ) p COOR 14 , —(CH 2 ) p NR 51 R 52 , —(CH 2 ) p CONR 51 R 52 , —CH═NOH, —CH═NO—(C 1 -C 6 ) alkyl, and —C(O)aryl wherein the aryl is optionally substituted by alkyl; R 11 and R 12 are selected independently from the group consisting of hydrogen, alkyl and halogen; W is O or S; R 13 and R 14 are each independently hydrogen or alkyl; R 51 and R 52 are each independently hydrogen or alkyl; or R 15 and R 16 can be taken together with the nitrogen to which they are attached to form a 4-6 membered saturated ring optionally containing one or more O, S or N atoms; p is 0 or 1; R 15 is hydrogen or alkyl; X is —F-G F is selected from the group consisting of aryl optionally substituted by alkyl; n is an integer from 0 to 3; s is an integer from 1 to 3; R 16 is selected from the group consisting of hydrogen, alkyl, and hydroxyalkyl; R 17 is selected from the group consisting of hydroxy, dialkylamino and aryl; G is or F and G taken together can form a cycloalkyl group having an aryl group fused thereto; and R 18 , R 19 and R 20 are selected independently from the group consisting of hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, hydroxy, trifluoromethoxy, aryloxy, —(CO)aryl, carboxy, carbalkoxy, amino, aminoalkyl, alkylamino, dialkylamino and aryl optionally substituted by alkyl; or when R 18 is hydrogen and R 19 and R 20 are on adjacent carbon atoms, then R 19 and R 20 can together form —O(—CH 2 ) m —O— wherein m is 1 or 2; R 21 and R 22 are each independently hydrogen or hydroxyl; or R 21 and R 22 taken together with the carbon to which they are attached can form a carbonyl group; R 23 , R 24 and R 25 are selected independently from the group consisting of hydrogen, alkyl, alkoxy, carbalkoxy, dialkylamino, NH 2 and phenyl optionally substituted with —CH 3 ; and R 50 is H or halogen; or a salt thereof.