Patent ID: 8198432

Claim:
An 124 I-phenyl compound of a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopourinimide having the formula: or a pharmaceutically acceptable derivative thereof, wherein: R 1 and R 2 are each independently substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, —C(O)R a or —COOR a or —CH(CH 3 )(OR a ) or —CH(CH 3 )(O(CH 2 ) n XR a ) where R a is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted cycloalkyl where R 2 may be CH═CH 2 , CH(OR 20 )CH 3 , C(O)Me, C(═NR 20 )CH 3 or CH(NHR 20 )CH 3 ; where X is an aryl or heteroaryl group; n is an integer of 0 to 6; where R 20 is methyl, butyl, heptyl, dodecyl or 3,5-bis(trifluoromethyl)-benzyl; and R 1a and R 2a are each independently hydrogen or substituted or unsubstituted alkyl, or together form a covalent bond; R 3 and R 4 are each independently hydrogen or substituted or unsubstituted alkyl; R 3a and R 4a are each independently hydrogen or substituted or unsubstituted alkyl, or together form a covalent bond; R 5 is hydrogen or substituted or unsubstituted alkyl; R 6 and R 6a are each independently hydrogen or substituted or unsubstituted alkyl, or together form ═O; R 7 is a covalent bond, alkylene, azaalkyl, or azaaraalkyl or ═NR 20 ; R 8 and R 8a are each independently hydrogen or substituted or unsubstituted alkyl or together form ═O; R 9 and R 10 are each independently hydrogen, or substituted or unsubstituted alkyl and R 9 may be —CH 2 CH 2 COOR a where R a is an alkyl group; each of R a , R 1a -R 4a , R 6a , R 8a , R 1 -R 10 , when substituted, is substituted with one or more substituents each independently selected from Q, where Q is alkyl, haloalkyl, halo, or —COOR b where R b is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, araalkyl, or OR c , where R c is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl or CONR d R e where R d and R e are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl, or NR f R g where R f and R g are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl, or ═NR h where R h is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl, or is an amino acid residue; each Q is independently unsubstituted or is substituted with one or more substituents each independently selected from Q 1 , where Q 1 is alkyl, haloalkyl, halo, pseudohalo, or —COOR b where R b is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, araalkyl, or OR c where R c is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl or CONR d R e where R d and R e are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl, or NR f R g where R f and R g are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl, or ═NR h where R h is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, or aryl, or is an amino acid residue; with the proviso that the compound contains at least one Q containing a 124 I-phenyl group.