Patent ID: 8703949

Claim:
A one pot process for preparing a compound represented by Formula (IV) from a compound represented by Formula (II), the process comprising: a) contacting the compound represented by Formula (II) with a nucleophile to form a compound represented by Formula (III); and b) contacting the compound represented by Formula (III) with carbon dioxide gas followed by an N-alkylating agent comprising R 17 X to form the compound represented by Formula (IV); wherein: R 1 and R 2 are independently chosen from hydrogen, halogen, hydroxy, amino, cyano, {—}OR 8 , hydrocarbyl, and substituted hydrocarbyl; R 3 is chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 14 is chosen from hydrogen, halogen, hydroxy, {—}OR 8 , hydrocarbyl, and substituted hydrocarbyl; R 8 Z are independently chosen from hydrocarbyl and substituted hydrocarbyl; R 17 is chosen from cycloalkyls, allyls, and benzyls; X is a leaving group; Y is chosen from hydroxy, alkoxy, aryloxy, and acetal, wherein each dashed line indicates an optional double bond; and the nucleophile is chosen from potassium hydroxide, sodium hydroxide, magnesium hydroxide, calcium hydroxide, potassium carbonate, and sodium carbonate.