Patent ID: 7262309

Claim:
A compound of the formula I wherein X is selected from the group consisting of CH 2 , O, S, S(═O), S(═O) 2 , and NR a , wherein R a is hydrogen or a protecting group; Y and Z are each independently selected from the group consisting of hydrogen, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, trifluoromethyl, halo-C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, trifluoromethoxy, C 1 -C 4 alkanoyl, amino, amino-C 1 -C 4 alkyl, C 1 -C 4 -alkylamino, N-(C 1 -C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, thiol, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulfinyl, carboxy, C 1 -C 4 alkoxycarbonyl, and nitro; one of is present and is selected from the group consisting of R 1 is a C 1 -C 7 alkyl group optionally substituted with at least one substituent selected from the group consisting of halogen, hydroxy, C 1 -C 4 alkoxy, thiol, C 1 -C 4 alkylthio, amino, N-(C 1 -C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, C 1 -C 4 alkylsulfonyl, and C 1 -C 4 alkylsulfinyl; a C 1 -C 7 alkyloxycarbonyl or a substituent of the formula II wherein R 2 and R 3 are each independently selected from the group consisting of hydrogen, C 1 -C 4 alkyl, and aryl or R 2 and R 3 taken together with the nitrogen atom to which they are attached form a heterocycle or heteroaryl group which is optionally substituted with one or two substituents selected from the group consisting of halogen, C 1 -C 4 alkyl, cyano, nitro, hydroxy, C 1 -C 4 alkoxy, thiol, C 1 -C 4 alkylthio, amino, N-(C 1 C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, C 1 -C 4 alkylsulfonyl, and C 1 -C 4 alkylsulfinyl; n is an integer from 0 to 3; m is an integer from 1 to 3; Q 1 and Q 2 are each independently selected from the group consisting of oxygen, sulphur, wherein y 1 and y 2 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkanoyl, thiol, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkylsulfinyl, nitro; a C 1 -C 4 alkyl optionally substituted with at least one substituent selected from the group consisting of halogen atom, hydroxy, C 1 -C 4 alkoxy, thiol, C 1 -C 4 alkylthio, amino, N-(C 1 -C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, C 1 -C 4 alkylsulfonyl, and C 1 -C 4 alkylsulfinyl; and an aryl group optionally substituted with one or two substituents selected from the group consisting of halogen, C 1 -C 4 alkyl, cyano, nitro, hydroxy, C 1 -C 4 alkoxy, thiol, C 1 -C 4 alkylthio, amino, N-(C 1 -C 4 -alkyl)amino, N,N-di(C 1 -C 4 -alkyl)amino, C 1 -C 4 alkylsulfonyl, and C 1 -C 4 alkylsulfinyl; or y 1 and y 2 taken together with the carbon atom to which they are attached form a carbonyl group or an imino group; and pharmaceutically acceptable salts and solvates thereof.