Patent ID: 7297493

Claim:
A method of detecting a chromosomal rearrangement consisting of fusion of a fibroblast growth factor receptor activating gene 1 (FRAG1) gene to a fibroblast growth factor receptor 2 (FGFR2) gene in a chromosome of a subject, comprising: incubating a chromosome of a subject with a nucleic acid molecule under conditions that allow the nucleic acid molecule to hybridize specifically with the chromosome, wherein the nucleic acid molecule comprises the complement of a nucleic acid sequence encoding amino acids 697-822 of FGFR2-WT and hybridizes under stringent conditions to a FRAG1 nucleic acid sequence comprising SEQ ID NO: 11, wherein the stringent conditions consist of hybridization at 65° C. in a hybridization solution comprising 6× SSC, 5× Denhardt's reagent, 0.5% SDS, 100 μg/ml denatured and fragmented salmon sperm DNA; and comparing hybridization of the nucleic acid molecule to the chromosome with hybridization of the nucleic acid molecule to a control chromosome lacking the chromosomal rearrangement, thereby detecting the chromosomal rearrangement.