Patent ID: 7053065

Claim:
A method of reducing toxicity associated with the administration of pemetrexed disodium comprising administering an effective amount of pemetrexed disodium in combination with about 500 μg to about 1500 μg of a methylmalonic acid lowering agent selected from the group consisting of vitamin B 12 , hydroxocobalamin, cyano-10-chlorocobalamin, aquocobalamin perchlorate, aquo-10-chlorocobalamin perchlorate, azidocobalamin, chlorocobalamin, cobalamin, and cyanocobalamin wherein the methylmalonic acid lowering agent is administered from about 1 to about 3 weeks prior to the first administration of pemetrexed disodium and the methylmalonic acid lowering agent administration is repeated from about every 6 weeks to about every 12 weeks.