Patent ID: 7595343

Claim:
A compound of structural formula (2a): or a pharmaceutically acceptable salt thereof, wherein Ar a is phenyl or thienyl; R 6 is H, or C 1 -C 6 -alkyl; Y and Z are —CH═; W is (V′-L 4 ) t -V-L 3 -; L 3 is a direct bond, —C 1 -C 6 -hydrocarbyl, —(C 1 -C 3 -hydrocarbyl) m1 -X′—(C 1 -C 3 -hydrocarbyl) m2 , —NH—(C 0 -C 3 -hydrocarbyl), (C 1 -C 3 - hydrocarbyl)-NH—, or —NH—(C 1 -C 3 -hydrocarbyl)-NH—; m1 and m2 are independently 0 or 1; X′ is —N(R 21 )—, —C(O)N(R 21 )—, N(R 21 )C(O)—, —O—, or —S—; R 21 is —H, V″—(C 1 -C 6 -hydrocarbyl) c ; L 4 is (C 1 -C 6 -hydrocarbyl) a -M-(C 1 -C 6 -hydrocarbyl) b ; a and b are independently 0 or 1; M is —NH—, —NHC(O)—, —C(O)NH—, —C(O)—, —SO 2 —, —NHSO 2 —, or —SO 2 NH— V, V′, and V″ are independently selected from cycloalkyl, heterocyclyl, aryl, and heteroaryl; t is 0 or 1; or W, the annular C to which it is bound, and Y together form a monocyclic cycloalkyl, heterocyclyl, aryl, or heteroaryl; and wherein the A and Ar a rings are optionally further substituted with from 1 to 3 substituents independently selected from methyl, hydroxy, methoxy, halo, and amino.