Patent ID: 7220720

Claim:
An optionally substituted peptide consisting of the structure: wherein X 1 , X 2 , X 3 , X 4 , X 5 and X 17 is not present; X 6 is either arginine, alanine, leucine, glycine, lysine, proline, asparagine, serine, histidine, nitroarginine, norleucine, or des-amino-arginine, or a derivative thereof, wherein said derivative is a corresponding D-amino acid, X 7 is either cysteine, homocysteine, or penicillamine, or a derivative thereof, wherein said derivative is a corresponding D-amino acid; X 8 is either methionine, norleucine, leucine, isoleucine, valine, methioninesulfoxide, or methioninesulfone, or a derivative thereof, wherein said derivative is a corresponding N-alkyl-amino acid; X 9 is either leucine, isoleucine, valine, alanine, or methionine; X 10 is either glycine, alanine, leucine, norleucine, cyclohexylalanine, asparagine, serine, sarcosine, gamma-aminobutyric acid, D-leucine, D-norleucine, or D-proline, or a derivative thereof, wherein said derivative is a corresponding N-alkyl-amino acid; X 11 is either arginine, lysine, citrulline, histidine, or nitroarginine, or a derivative thereof, wherein said derivative is a corresponding N-alkyl-amino acid; X 12 is either valine, leucine, isoleucine, alanine, or methionine; X 13 is either phenylalanine, tyrosine, D-(p-benzoylphenylalanine), tryptophan, (1′)- and (2′)-naphthylalanine, cyclohexylalanine, or mono and multi-substituted phenylalanine wherein each substituent is independently selected from the group consisting of O-alkyl, alkyl, OH, NO 2 , NH 2 , F, I, and Br; X 14 is either arginine, lysine, histidine, or norarginine; X 15 is either proline, alanine, valine, leucine, isoleucine, methionine, or sarcosine; X 16 is either cysteine, homocysteine, or penicillamine, or a derivative thereof, wherein said derivative is a corresponding D-amino acid; Z 1 is an optionally present protecting group that, if present, is covalently joined to the N-terminal amino group; Z 2 is an optionally present protecting group that, if present, is covalently joined to the C-terminal carboxy group; or a labeled derivative of said peptide; or a pharmaceutically acceptable salt of said peptide or of said labeled derivative.