Patent ID: 6861431

Claim:
A method of modulating an efflux capability of an ABC transporter of a cell or tissue comprising contacting the cell or tissue with a compound that promotes or inhibits efflux of a substrate via the ABC transporter, wherein activity of the ABC transporter through gene expression is unaffected, wherein the compound is selected from the group consisting of 1-carbazol-9-yl-3-(3,5-dimethylpyrazol-1-yl)-propan-2-ol, 2-(4-chloro-3,5-dimethylphenoxy)-N-(2-phenyl-2H-benzo-triazol-5-yl)-acetamide, N-[2-(4-chlorophenyl)acetyl]-N′-(4,7-dimethylguin-azolin-2-yl)-guanidine, 1-benzyl-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]iso-quinoline, N-(3-benzooxazol-2-yl-4-hydroxyphenyl)-2-p-tolyloxy-acetamide, 8-allyl-2-phenyl-8H-1,3a,8-triaza-cyclopenta[a]indene, 3-(4-chlorobenzyl)-5-(2-methoxyphenyl) [1,2,4]-oxadiazole, 2-phenethylsulfanyl-5,6,7,8-tetrahydro-benzo[4, 5]-thieno[2,3-d]pyrimidin4-ylamine, (5,12,13-triaza-indeno[1,2-b]anthracen-13-yl)-acetic acid ethyl ester, 2,2′-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)bis-phenol,2-(2-chlorophenyl)-5-(5-methylthiophen2-yl)-[1,3,4]-oxadiazole, 2-p-tolyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]-thiazole, and mixture thereof.