Patent ID: 7323311

Claim:
A method of screening for an antibody or antibody fragment that binds eotaxin, the method comprising: providing by way of deletion, substitution or insertion of one or more amino acids in the amino acid sequence of a CAT-212 VH domain (SEQ ID NO 2), one or more VH domains each of which is an amino acid sequence variant of the CAT-212 VH domain, and combining one or more VH domain amino acid sequence variants thus provided with one or more VL domains to provide one or more VH/VL combinations; and/or providing by way of deletion, substitution or insertion of one or more amino acids in the amino acid sequence of a CAT-212 VL domain (SEQ ID NO 4), a VL domain which is an amino acid sequence variant of the CAT-212 VL domain, and combining one or more VL domain amino acid sequence variants thus provided with one or more VH domains to provide one or more VH/VL domain combinations; and testing the VH/VL combination or combinations to identify an antibody or antibody fragment that binds eotaxin.