Patent ID: 7881872

Claim:
A method for generating at least one error-corrected experiment profile of at least one experiment profile in a plurality of pairs of profiles {A m , C m }, wherein m=1, 2, . . . , M, and M is the number of the pairs of profiles; and wherein, for each m ∈ {1, 2, . . . , M}, A m is an experiment profile, and C m is a reference profile; and wherein {A m } represents experiment profiles in said plurality of pairs of profiles {A m , C m } and {C m } represents reference profiles in said plurality of pairs of profiles {A m , C m }, said method comprising: (a) calculating, on a suitably programmed computer, an average reference profile C of said plurality of reference profiles {C m } where m=1, 2, . . . , M; (b) determining, on a suitably programmed computer, for at least one profile pair {A m , C m } where m ∈ {1, 2, . . . , M} of said plurality of pairs of profiles {A m , C m } a differential reference profile, C diff (m,k), computed between C m and C , wherein said average reference profile C comprises data set { C (k)}; (c) via said differential reference profile determined for said profile pair, removing, on a suitably programmed computer, systematic cross-experiment error from an experiment profile A m of said at least one profile pair {A m , C m } where m ∈ {1, 2, . . . , M} to generate a first error-corrected experiment profile A′ m for each m ∈ {1, 2, . . . , M}, wherein said experiment profile A m comprises a first data set, {A m (k)}, said reference profile C m comprises a second data set, and said first error-corrected experiment profile A′ m comprises data set {A′ m (k)}; wherein said first data set comprises measurements of a plurality of different cellular constituents measured in a sample having been subject to a first condition, said second data set comprises measurements of said plurality of different cellular constituents measured in a sample having been subject to a second condition; and wherein k=1, 2, . . . , N; k is an index of measurements of said plurality of different cellular constituents, N being the total number of measurements, wherein generating respective A′ m (k) of said first error-corrected experiment profile A′ m comprises subtracting C diff (m,k) from A m (k); and (d) outputting to a user, a user interface device, a computer readable storage medium, or a local or remote computer system; or displaying: said first error-corrected experiment profile A′ m or said data set {A′ m (k)}.