Patent ID: 7700609

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: X is —CH═CH—, —S—CH 2 —, —CH 2 —S—, —CH 2 —O—, —O—CH 2 —, or —(CH 2 ) 3 —, wherein one or more of the hydrogen substituents are optionally and independently replaced with m occurrences of —WR y , wherein m is an integer selected from 0 to 5; R 1 and R 2 , taken together with the carbon atoms to which they are bound form an optionally substituted 5-membered heteroaryl thiophene ring, wherein the ring formed by R 1 and R 2 taken together is optionally and independently substituted at one or more carbon atoms with m occurrences of —WR y , wherein m is an integer selected from 0 to 5; each occurrence of W is independently a bond or is a C 1 -C 6 alkylidene chain wherein up to two non-adjacent methylene units of W are independently optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each occurrence of R y is independently selected from R′, halogen, NO 2 , or CN, or —WR y is ═O, ═S, or ═NR′; T is CHR′, CH 2 CH(R′), —S(═O) 2 , or C(═O); n is 0 or 1; Cy 1 is a 3-7 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein Cy 1 is optionally and independently substituted at one or more carbon atoms with k occurrences of -QR X , wherein k is an integer selected from 0 to 5; and at one or more substitutable nitrogen atoms with —R 4 ; wherein Q is a bond or is a C 1 -C 6 alkylidene chain wherein up to two non-adjacent methylene units of Q are independently optionally replaced by CO, CO 2 , COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO 2 , NRCONR, SO, SO 2 , NRSO 2 , SO 2 NR, NRSO 2 NR, O, S, or NR; and each occurrence of R X is independently selected from R′, halogen, NO 2 , CF 3 , or CN, or -QR X is ═O, ═S, or ═NR′; each occurrence of R 3 and R 4 is independently R′, —COR′, —CO 2 (C 1-6 aliphatic), —CON(R′) 2 , or —SO 2 R′; each occurrence of R is independently selected from hydrogen or an optionally substituted C 1-6 aliphatic group; and each occurrence of R′ is independently selected from hydrogen or an optionally substituted group selected from C 1-8 aliphatic, C 6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms, or wherein R and R′ taken together with the atom(s) to which they are bound, or two occurrences of R′ taken together with the atom(s) to which they are bound, form an optionally substituted 3-8 membered cycloalkyl, heterocyclyl, aryl, or heteroaryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and the dashed bond represents a single or double bond, as valency permits.