Patent ID: 8741283

Claim:
A method of treating a patient having a tumor or cancer of the prostate or ovaries comprising administering an effective amount of adenosine deaminase to the patient in need thereof, wherein the adenosine deaminase is adenosine deaminase purified from a bovine source or is a recombinant bovine adenosine deaminase according to SEQ ID NO: 5 or SEQ ID NO: 1, or is a recombinant bovine adenosine deaminase according to SEQ ID NO: 1 or SEQ ID NO: 5, with an amino acid substitution selected from the group consisting of Gln in place of Lys 198 ; Ala in place of Thr 245 ; Arg in place of Gly 351 and combinations thereof; wherein the adenosine deaminase is conjugated to polyethylene glycol; and wherein the polyethylene glycol ranges in size from about 4,000 to about 45,000 Daltons.