Patent ID: 8883963

Claim:
An isolated peptidomimetic having a sequence of Formula (I), A-Z 1 —Z 2 —Z 3 —Z 4 —Z 5 —Z 6 —Z 7 —Z 8 —Z 9 —Z 10 —Z 11 —B (I) wherein, A represents —NH—R 1 , R 3 —CO—, R 3 —O—CO— or R 3 —SO 2 —, wherein R 1 represents hydrogen, or optionally substituted linear or branched (C 1 -C 10 ) alkyl chain; R 3 is selected from linear or branched (C 1 -C 10 ) alkyl, (C 3 -C 6 ) cycloalkyl, aryl, heteroaryl and arylalkyl groups; B represents —COOR 2 , —CONHR 2 or CH 2 OR 2 , wherein R 2 represents H, or an optionally substituted group selected from linear or branched (C 1 -C 10 ) alkyl, aryl and aralkyl groups; Z 1 to Z 11 represent natural or unnatural amino acids, linked together by amide bond, wherein Z 1 represents L-Histidine (H), D-Histidine (dH) or Urocanic acid (UA); Z 2 represents a naturally or unnaturally occurring amino acid selected from L-Serine (S), D-Serine (dS), L-Alanine (A), D-Alanine (dA), α-methyl proline (α-Me-Pro), α-amino-isobutyric acid (Aib), 1-amino cyclopropane carboxylic acid (ACP), and 1-amino-cyclopentanecarboxylic acid (APP); Z 3 represents L-Glutamine (Gln; Q), D-Glutamine (dQ) or a compound of formula II (CNB or Hfl); Z 4 represents Glycine (G) or an unnatural amino acid 1-amino cyclopropane carboxylic acid (ACP) or 1-amino-cyclopentanecarboxylic acid (APP); Z 5 represents a naturally or nonnaturally occurring amino acid comprising a hydroxyl side chain; a preferred Z 5 is L-Threonine (T), D-Threonine (dr), L-Allo-threonine (allo-Thr; allo-T), D-Allo-threonine (d-allo-Thr; d-allo-T); Z 6 represents a naturally or unnaturally occurring amino acid having a disubstituted alpha carbon having two side chains, wherein each of them may independently be an optionally substituted alkyl or aryl or an aralkyl group wherein the substituents are selected from one or more alkyl groups or one or more halo groups; Z 7 and Z 8 independently represent a naturally or non-naturally occurring amino acid comprising a hydroxyl side chain; Z 9 independently represents a naturally or nonnaturally occurring amino acid having an amino acid side chain comprising an acidic group; Z 10 represents L or D unnatural amino acid of formula III (a-c); and Z 11 represents L or D unnatural amino acid of formula IV (a-l); or a tautomer of formula (I).