Patent ID: 7074934

Claim:
A tryptase inhibitor compound of formula (I) where: R 5 represents amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen; R 6a represents hydrogen or methyl; Xâ€”X is selected from â€”CHâ•CHâ€”, â€”CONR 1a â€”, â€”NHâ€”COâ€”, â€”NR 1a â€”CH 2 â€”, â€”CH 2 â€”NR 1a â€”, â€”CH 2 Oâ€”, â€”OCH 2 â€”, â€”COOâ€”, â€”OCâ•Oâ€” and â€”CH 2 CH 2 â€”; R 1a represents hydrogen, (1-6C)alkyl or phenyl(1-6C)alkyl; L is CO or CONR 1d (CH 2 ) m in which m is 0 or 1 and R 1d is hydrogen, (1-6C)alkyl or phenyl(1-6C)alkyl; Cy is cycloalkyl, piperidinyl, 3,4-methylenedioxyphenyl, furyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyrimidinyl, pyrazinyl, naphthyl, benzofuryl or benzo[b]thienyl group, optionally substituted by R 3a or R 3i X i in which X i is a bond, O, NH, CO, CONH, NHCO, SO 2 , NHSO 2 or SO 2 NH, CH 2 and R 3i is phenyl or pyridyl optionally substituted by R 3a ; each R 3a independently is hydrogen, hydroxyl, (1-6C)alkoxy, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkanoyl, (1-6C) alkylaminoalkyl, hydroxy(1-6C)alkyl, carboxy, (1-6C) alkoxyalkyl, (1-6C) alkoxycarbonyl, (1-6C) alkylaminocarbonyl, amino(1-6C)alkyl CONH 2 , CH 2 CONH 2 , aminoacetyl, (1-6C)alkanoylamino, hydroxy(1-6C)alkanoylamino, amino(1-6C)alkanoylamino, (1-6C)alkylamino(1-6C)alkanoylamino, di(1-6C)alkylamino(1-6C)alkanoylamino, (1-6C) alkoxycarbonylamino, amino, halo, cyano, nitro, thiol, 1-6C) alkylthio, (1-6C) alkylsulphonyl, (1-6C) alkylsulphenyl, imidazolyl, hydrazido,(1-6C)alkylimidazolyl,(1-6C) alkylsulphonamido, (1-6C) alkylaminosulphonyl, aminosulphonyl, (1-6C) haloalkoxy, or (1-6C) haloalkyl; and Lp is a lipophilic group; or a physiologically tolerable salt thereof.