Patent ID: 7709508

Claim:
A method for treating an estrogen-mediated condition selected from the group consisting of uterine fibroid disease, hot flashes, perimenopausal depression and premenstrual syndrome in a mammal in need thereof, wherein the method comprises administering to the mammal: a therapeutically effective amount of a compound of the formula: wherein X is O or N—OH, R 1 is hydrogen, fluoro, chloro, bromo, iodo or C 1-4 alkyl, wherein the alkyl group is optionally substituted with 1, 2 or 3 groups selected from the group consisting of fluoro, chloro and bromo, R 2 is hydrogen, R 3 is hydrogen, R 4 is hydrogen, and R 5 is hydrogen; or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof; and a second active agent selected from the group consisting of an organic bisphosphonate, a cathepsin K inhibitor, an estrogen, an estrogen receptor modulator, an androgen receptor modulator, an inhibitor of osteoclast proton ATPase, an inhibitor of HMG-CoA reductase, an integrin receptor antagonist, an osteoblast anabolic agent, calcitonin, Vitamin D, a synthetic Vitamin D analogue, a selective serotonin reuptake inhibitor and an aromatase inhibitor; or a pharmaceutically acceptable salt or mixture thereof.