Patent ID: 7655765

Claim:
A composition of matter of the formula (X 1 ) a —F 1 —(X 2 ) b and multimers thereof, wherein: F 1 is an IgG1 Fc domain comprising SEQ ID NO: 603 modified so that it comprises at least one X 3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS: 621, 622, 624, 625, 627, 628, 630, 632, 634, and 636 within a loop region of the IgG1 Fc domain, said loop region being in a non-terminal domain of the Fc domain; X 1 and X 2 are each independently selected from -(L 1 ) c -P 1 , -(L 1 ) c -P 1 -(L 2 ) d -P 2 , -(L 1 ) c -P 1 -(L 2 ) d -P 2 -(L 3 ) e -P 3 , and -(L 1 ) c -P 1 -(L 1 ) d -P 2 -(L 3 ) e -P 3 -(L 4 ) f -P 4 ; X 3 is independently selected from -(L 5 ) c -P 5 , -(L 5 ) c -P 5 -(L 6 ) d -P 6 , -(L 5 ) c -P 5 -(L 6 ) d -P 6 -(L 7 ) e -P 7 , and -(L 5 ) c -P 5 -(L 6 ) d -P 6 -(L 7 ) e -P 7 -(L 8 ) f -P 8 ; P 1 , P 2 , P 3 , and P 4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides; P 5 , P 6 , P 7 , and P 8 are each independently sequences of pharmacologically active peptides; L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , and L 8 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1.