Patent ID: 8506991

Claim:
A method of producing a nicotine transdermal preparation comprising a support and an adhesive layer formed thereon, which adhesive layer comprising an acrylic adhesive comprising a main component which is (meth)acrylic acid alkyl ester and comprising a secondary monomer and a tertiary monomer both copolymerized with said main component, said second monomer being a monomer capable of being involved in a crosslinking reaction, said tertiary monomer comprising one or more kinds of monomer components selected from the group consisting of vinyl esters, vinyl ethers, vinyl amides, hydroxyl group-containing monomers, amido group-containing monomers, alkoxy group-containing monomers, and vinyl monomers, nicotine and a fatty acid alkyl ester or glycerol fatty acid ester, which method comprises providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and continuously applying a coating solution consisting solely of nicotine to the adhesive layer with a die coater to allow absorption of nicotine into the adhesive layer, wherein the fatty acid alkyl ester or glycerol fatty acid ester is contained in a proportion of 40-65 wt % relative to the adhesive layer before containing nicotine.