Patent ID: 7344892

Claim:
A method of determining whether a pregnant subject has, or is predisposed to having, preeclampsia, the method comprising: a) measuring a level of sex hormone binding globulin (SHBG) in a biological sample comprising serum or blood obtained from a pregnant subject; b) measuring a level of placental growth factor (PlGF) in a biological sample comprising serum or blood obtained from the pregnant subject; c) comparing the SHBG level obtained from the pregnant subject with a reference SHBG level obtained from at least one subject having a normal pregnancy; and d) comparing the PlGF level obtained from the pregnant subject with a reference PlGF level obtained from at least one subject having a normal pregnancy, wherein low levels of SHBG and PlGF present in the sample obtained from the pregnant subject, as compared to the levels present in the at least one subject having a normal pregnancy, indicate that the pregnant subject has, or is predisposed to having, a gestational disorder.