Patent ID: 7897768

Claim:
A method of preparing a TBZ compound having structure I, said method comprising: (a) reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide a first intermediate having structure III; and (b) removing protecting group P 1 and inducing an amino cyclization reaction to provide a product TBZ compound having structure I, wherein with respect to structures I, II, and III; R 1 -R 4 are independently hydrogen, a halogen atom, a C 1 -C 20 aliphatic radical, a C 2 -C 20 cycloaliphatic radical, or a C 2 -C 20 aromatic radical; R 5 -R 11 are independently hydrogen, a C 1 -C 20 aliphatic radical, a C 2 -C 20 cycloaliphatic radical, or a C 2 -C 20 aromatic radical; P 1 is a protecting group, and Q 1 is hydrogen.