Patent ID: 7399762

Claim:
A method of treating pain in a subject in need thereof, comprising: administering to said subject a composition comprising an opioid receptor agonist and a physiologically acceptable carrier, wherein the opioid receptor agonist is a compound of formula (I): wherein R 1 is C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylaryl or one of the following groups: or —(CH 2 ) n (Het), wherein (Het) is a member selected from R is hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylaryl, —CO 2 R 8 ; R 2 is H, halogen, C 1-4 alkyl, CN or OCH 3 ; Y is OH, OR 9 , C 1-8 alkyl, F, Cl, Br, CF 3 or CN; W is a member selected from the group consisting of: H, OH, —CO 2 R 8 ; amino, —NR 3 SO 2 R 7 , —NR 3 CO 2 R 7 , —CONH 2 ; and —NHCHO n is 1, 2, 3 or 4; R 3 is hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylaryl, —CH 2 Y or —CO 2 R; R 4 is hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, or C 1-8 alkylaryl; R 5 and R 6 are each, independently, hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, or C 1-8 alkylaryl; R 7 and R 8 are each independently, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, or C 1-8 alkylaryl.