Patent ID: 8647656

Claim:
An ODT composition consisting essentially of: a therapeutically effective amount of lamotrigine microcapsules comprising 25 or 200 mg of lamotrigine crystals having an average particle size of about 1-50 μm, coated with a taste-masking layer; a disintegrant; and a sugar alcohol, a saccharide, or both a sugar alcohol and a saccharide; wherein after a single oral administration said ODT composition provides: a C max in the range of 0.276 to 0.482 ng/mL of lamotrigine, an AUC 0-24 in the range of 4.87 to 8.17 ng·hr/mL of lamotrigine, or both a C max in the range of 0.276 to 0.482 ng/mL of lamotrigine and an AUC 0-24 in the range of 4.87 to 8.17 ng·hr/mL of lamotrigine, if the total amount of lamotrigine in the ODT is 25 mg, or a C max in the range of 2.21 to 3.95 ng/mL of lamotrigine, an AUC 0-24 in the range of 36.0 to 63.6 ng·hr/mL of lamotrigine, or both a C max in the range of 2.21 to 3.95 ng/mL of lamotrigine and an AUC 0-24 in the range of 36.0 to 63.6 ng·hr/mL of lamotrigine, if the total amount of lamotrigine in the ODT is 200 mg.