Patent ID: 6992097

Claim:
A compound of formula I wherein: A is C 1 -C 6 alkyl, aryl, C 1 -C 6 alkylaryl, C 1 -C 6 alkyl(O)C 1 -C 6 alkylaryl, C 1 -C 6 alkyl(S)C 1 -C 6 alkylaryl, indolyl, indolinyl, thienyl, (C 1 -C 6 alkyl)thienyl, benzothienyl, benzofuranyl, naphthanyl, cyclohexyl, (C 1 -C 6 alkyl)indolyl, (C 1 -C 6 alkyl)benzothienyl, (C 1 -C 6 alkyl)naphthanyl, (C 1 -C 6 alkyl)benzofuranyl, and (C 1 -C 6 alkyl)cyclohexyl; B is NH 2 , NHR 1 , C 1 -C 6 alkylNH 2 , C 1 -C 6 alkylNHR 1 , C 1 -C 6 alkylarylNH 2 , C 1 -C 6 alkylarylNHR 1 , C 1 -C 6 alkylcyclohexylNH 2 , C 1 -C 6 alkylcyclohexylNHR 1 , R 1 -piperidin-3-yl(C 1 -C 6 alkyl), R 1 -piperidin-2-yl(C 1 -C 6 alkyl), R 1 -piperidin-4-yl(C 1 -C 6 alkyl), R 1 -quinolin-2-yl(C 1 -C 6 alkyl), R 1 -(2,4-dihydroquinolin-2-yl(C 1 -C 6 alkyl), R 1 -isoquinolin-2-yl(C 1 -C 6 alkyl), and R 1 -(2,4-dihydroisoquinolin-2-yl(C 1 -C 6 alkyl); R 1 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkyl(OH), or C 1 -C 6 alkylidenyl(OH)R 2 ; R 2 is C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkyl(O)C 1 -C 6 alkyl, C(O)O—C 1 -C 6 alkyl, aryl, or C 1 -C 6 alkylaryl; X is C 1 -C 6 alkylidenyl, O, S, NH, or N(C 1 -C 6 alkyl); V is D is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkyl(O)(CO)C 1 -C 6 alkyl, C 1 -C 6 alkyl(O)(CO)N(C 1 -C 6 alkyl) 2 , C(O)R 6 , C 1 -C 6 alkyl(O)R 6 , C 1 -C 6 alkyl(OH), C 1 -C 6 alkylC(O)R 6 , C 1 -C 6 alkylR 6 , (C 1 -C 6 alkyl)NHSO 2 (C 1 -C 6 alkyl), R 6 is H, C 1 -C 6 alkyl, naphthyl, acetyl, NH 2 , NH(C 1 -C 6 alkyl), NH(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), NH(C 1 -C 6 alkyl)S(C 1 -C 6 alkyl), NH(C 1 -C 6 alkylidenyl)OCH 3 , NH(C 3 -C 6 cycloalkyl), NH(C 1 -C 6 alkyl)C(O)(C 1 -C 6 alkyl), NH(C 1 -C 6 alkyl)NH(C 1 -C 6 alkyl), NH(C 1 -C 6 alkyl)C(O)O(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2 , O(C 1 -C 6 alkyl), E is hydrogen, C 1 -C 6 alkyl, C(O)C 1 -C 6 alkyl, aryl, (aryl)C(O)NR 6 , (aryl)(C 1 -C 6 alkyl)C(O)R 6 , C 1 -C 6 alkylaryl, C(O)aryl, C 1 -C 6 alkylC(O)aryl, naphthyl, C 1 -C 6 alkylnaphthyl, C(O)naphthyl, C 1 -C 6 alkylC(O)naphthyl, heteroaryl, C 1 -C 6 alkylheteroaryl, C(O)heteroaryl, C 1 -C 6 alkylC(O)heteroaryl, indanyl, C 1 -C 6 alkylindanyl, C(O)indanyl, C 1 -C 6 alkylC(O)indanyl, cycloalkyl; G is hydrogen, C 1 -C 6 alkyl, aryl, C 1 -C 6 alkylaryl, and C 1 -C 6 alkenyl; J is hydrogen, C 1 -C 6 alkyl, aryl, and C 1 -C 6 alkylaryl; L is C 1 -C 6 alkyl; or a pharmaceutically acceptable salt or solvate thereof.