Patent ID: 8304202

Claim:
A method of drug screening, comprising: forming a plurality of assay mixtures each including a Bim polypeptide, a TRIM2 polypeptide, and at least one test compound, wherein the Bim polypeptide comprises an amino acid sequence with at least about 80% homology to one or more of SEQ ID NOS:1-5, wherein the TRIM2 polypeptide comprises an amino acid sequence with at least about 80% homology to one or more of SEQ ID NOS:6-12, and wherein at least one of the Bim and TRIM2 polypeptides comprises a fluorescent tag; detecting fluorescence signals from the fluorescent tag representing interaction of the Bim and TRIM2 polypeptides with each other; and determining based on the signals whether the at least one test compound in each assay mixture affected the ability of the Bim and TRIM2 polypeptides to interact.