Patent ID: 8742131

Claim:
A stereochemically pure compound with a stereochemical purity of at least 80% according to Formula (II): where R 1 is independently selected from phenyl or thienyl, both optionally substituted with an alkyl, alkoxy, halo, or COOR group; where R 2 is independently selected from phenyl, thienyl, cyclopentyl, cyclohexyl, 1-alkylcyclopentyl, 1-alkylcyclohexyl, 1-hydroxycyclopentyl or 1-hydroxycyclohexyl, where phenyl, thienyl, cyclopentyl, cyclohexyl, 1-alkylcyclopentyl, 1-alkylcyclohexyl,1-hydroxycyclopentyl or 1-hydroxycyclohexyl are optionally substituted with an alkyl, alkoxy, halo, or COOR group; or where R 1 and R 2 together are 9-xanthenyl, where 9-xanthenyl is substituted on either or both benzene rings with an alkyl, alkoxy, halo, or COOR group; where R 3 is OH; R 4 and R 5 are independently selected from lower alkyl, alkoxycarbonylalkyl, aralkyl, or aryloxyalkyl, where alkoxycarbonylalkyl and/or aralkyl are optionally substituted with an alkyl, alkoxy, halo, or COOR group; or R 4 and R 5 together with the ring to which they are attached form a five- or six-membered ring optionally substituted with aryl or aryloxy; where R is a lower alkyl; where *, **, and *** are each independently a stereocenter, and wherein the stereocenters *, **, and *** are present in one of the following combinations: (i) * is (R), ** is (R), and *** is (S), or (ii) * is (S), ** is (S), and *** is (R), or (iii) * is (R), ** is (S), and *** is (R) (iv) * is (S), ** is (R), and *** is (S); and X ⊖ represents a pharmaceutically acceptable anion.