Patent ID: 8623826

Claim:
A method of treating both nausea and vomiting for five consecutive days in a patient in need thereof, comprising: a) administering to said patient on day one netupitant or a pharmaceutically acceptable salt thereof, in a therapeutically effective amount which enters the systemic circulation, crosses the blood brain barrier and occupies at least 70% of neurokinin-1 (NK 1 ) receptors in the striatum seventy-two hours after said administration; b) administering to said patient on day one a therapeutically effective amount of palonosetron or a pharmaceutically acceptable salt thereof; and c) administering to said patient on day one a first dose of dexamethasone which is ineffective against chemotherapy induced nausea and vomiting (CINV) when administered alone, but effective against CINV when administered in combination with said netupitant, wherein said first dose of dexamethasone comprises from 50 to 70% of a minimum effective dose when administered alone against CINV; steps a b and (c) are effective to treat both nausea and vomiting during the period defined by days one through five; and steps (a), (b) and (c) are effective to treat both nausea and vomiting to a greater extent during the period defined by days one through five than steps (b) and (c) alone.