Patent ID: 8217024

Claim:
An applicator comprising a single unit-dose of a monophasic pharmaceutical composition comprising a conjugated estrogen and a hydrophilic excipient, wherein the composition has a viscosity greater than about 1 Poise and less than about 30,000 Poise, wherein the conjugated estrogen comprises a combination of sodium estrone sulfate, sodium equilin sulfate, sodium 17α-dihydroequilin sulfate, sodium 17β-dihydroequilin sulfate, sodium 17α-estradiol sulfate, sodium 17β-estradiol sulfate, sodium equilenin sulfate, sodium 17α-dihydroequilenin sulfate, sodium 17β-dihydroequilenin sulfate, and sodium Δ8,9-dehydroestrone sulfate, and wherein the diffusion of estrone or equilin from the composition across human vaginal tissue is from about 30% to about 90% at 24 hours.