Patent ID: 8354413

Claim:
A compound of formula I: wherein: a is 0, 1, 2, 3 or 4; b is 0, 1, 2, 3 or 4; c is 0 or 1; d is 0 or 1; e is 0 or 1; f is 0, 1, 2, 3, 4 or 5; g is 0 or 1; X is N or CH; Y is phenyl, a 5 membered unsaturated heterocycle containing 1, 2, 3 or 4 heteroatoms independently selected from 0, N and S, but not more than one of which is O or S, or a 6 membered unsaturated heterocycle containing 1, 2, 3 or 4 nitrogen atoms; Z is C or SO; each R 1 is independently hydroxy, halogen, cyano, nitro, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy or haloC 1-6 alkoxy; each R 2 is independently hydroxy, halogen, cyano, nitro, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy or haloC 1-6 alkoxy; R 3 is hydrogen or C 1-6 alkyl; each of R 4 and R 5 is independently hydrogen or C 1-6 alkyl; R 6 is hydrogen or C 1-6 alkyl; and R 7 is azetidinyl optionally substituted by one or more groups independently selected from A-(CR 8 R 9 ) q R 10 ; each A is independently a direct bond, O, (CH 2 ) s (C═O) t , (C═O)NR 11 , NR 11 (C═O), (C═O)O, O(C═O), (C═S)NR 11 , NR 11 or S(O) r ; each q is independently 0, 1, 2, 3, or 4; r is 0, 1 or 2; s is 0, 1, 2 or 3; t is 1 or 2; each of R 8 and R 9 is independently hydrogen, hydroxy, halogen, C 1-6 alkyl or haloC 1-6 alkyl; each R 10 is independently hydroxy, oxo, cyano, halogen, nitro, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, (C 1-6 alkylcarbonyl)amino or a ring which is: C 3-10 cycloalkyl; C 6-10 aryl; azetidinyl; a 5 or 6 membered saturated or partially saturated heterocyclic ring containing one, two or three atoms independently selected from N, O and S; a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S; a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms; or a 7-13 membered unsaturated, partially saturated, or saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of which rings being optionally substituted by one or more groups independently selected from R 12 ; R 11 is hydrogen or R 10 ; each R 12 is independently hydroxy, oxo, cyano, halogen, nitro, C 1-6 alkyl, C 1-6 alkoxy, C 2-10 alkenyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, —O(C═O)C 1-6 alkyl, —O(C═O)OC 1-6 alkyl, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, (C 1-6 alkylsulfonyl)amino, C 6-10 aryl, C 1-6 arylC 1-6 alkyl, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S or a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms; any of which rings being optionally substituted by one or more groups independently selected from halogen, C 1-6 alkyl and haloC 1-6 alkyl; or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.