Patent ID: 8148394

Claim:
A method of treating Alzheimer's disease in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein: R represents a group of Formula II or Formula III; one of A, B, D or E is a N atom, the remainder being CH groups; R 1 is selected from the group consisting of SO 2 Ar, C(O)Ar, CH 2 Ar and Ar; R 2 , R 3 and R 4 are independently selected from the group consisting of H and alkyl; represents a single or double bond, with the proviso that there is only one double bond in the ring at a time; n is an integer of from 1-3; Z is selected from the group consisting of C, CH and N, provided that when is a double bond, Z is C and when is a single bond, Z is selected from CH and N; and Ar is an optionally substituted aryl group; with the proviso that when R is a group of Formula II, R 1 is SO 2 Ar.