Patent ID: 7803825

Claim:
A compound of formula (Ia) wherein X is (CH 2 ) 0 ; m is 1, 2 or 3; n is 0, 1, 2 or 3; R is H, halogen or an optionally substituted C 1 -C 6 alkyl group; R 1 and R 2 are each independently H or an optionally substituted C 1 -C 6 alkyl group or R 1 and R 2 may be taken together with the atom to which they are attached to form an optionally substituted 4- to 7-membered cycloheteroalkyl; R 3 , R 4 , R 7 and R 8 are each independently H, or a C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, or C 6 -C 10 aryl group each optionally substituted; R 5 and R 6 are each independently H, halogen, OR 10 or C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; R 10 is H or an optionally substituted C 1 -C 6 alkyl group; and R 11 and R 12 are taken together with the atom to which they are attached to form an optionally substituted fused bicyclic 9- to 11-membered ring system optionally containing one to three additional heteroatoms selected from N, O or S; or a stereoisomer or a pharmaceutically acceptable salt thereof; wherein the optionally substituted groups are selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halo, nitro, cyano, hydroxy, C 6 -C 10 aryl, a 3-10 membered heterocyclyl ring, a 5-10 membered heteroaryl ring, —N(R a ) 2 , —C(O)R b , —OR c and —S(O) p R d ; wherein each R a is independently H, C 1 -C 4 alkyl, —CHO, —C(O)(C 1 -C 4 alkyl), or —C(O)—O—(C 1 -C 4 alkyl); each R b is independently H, —OH, O(C 1 -C 4 alkyl), C 1 -C 4 alkyl, —NH 2 , —NH(C 1 -C 4 alkyl), or —N(C 1 -C 4 alkyl) 2 ; each R c is independently H, C 1 -C 4 alkyl optionally substituted with halo, —CHO or —C(O)(C 1 -C 4 alkyl); each R d is independently C 1 -C 4 alkyl, or —OH; and p is 0, 1 or 2.