Patent ID: 8305582

Claim:
A method of detecting and collecting one or more sample components within a sample stream in a chromatography system during a chromatographic run comprising: generating a first signal during the chromatographic run from at least one destructive detector, including at least one evaporative particle detector, to generate a response value during the chromatographic run; generating a second signal during the chromatographic run from at least one non-destructive detector to generate a response value during the chromatographic run, wherein said at least one destructive detector allows for a positive detection of the response value of the one or more sample components in the presence of one or more chromaphoric solvents that obliterate a positive detection of the response value of the one or more sample components from the non-destructive detector; and collecting the one or more components from the stream in a fraction collector during the chromatographic run in response to a change in at least one of said signals during said chromatographic run.