Patent ID: 8187634

Claim:
A process for preparation of sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g comprising the steps of: (a) partially neutralizing an aqueous solution of polyallylamine hydrochloride with 65 to 70 mole % of alkali with respect to polyallylamine hydrochloride to obtain partially neutralized aqueous polyallylamine hydrochloride solution; (b) charging a dispersing agent and a hydrocarbon solvent to the partially neutralized aqueous polyallylamine hydrochloride solution to obtain a mixture; (c) heating the mixture at elevated temperature; (d) charging 5 to 12% by weight of epichlorohydrin with respect to polyallylamine hydrochloride to said mixture and maintaining elevated temperature till crosslinking is complete to obtain a wet cake; and (e) isolating and drying the wet cake at temperature of about 25° C. to about 90° C. to get sevelamer hydrochloride with phosphate binding capacity of 4.7 to 6.4 mmol/g.