Patent ID: 6956049

Claim:
A method of modulating the activity of metabotropic glutamate receptors, said method comprising: contacting said receptors with at least one compound having the structure A-L-B or enantiomers, diastereomeric isomers or mixtures of any two or more thereof, or pharmaceutically acceptable salts thereof, in an amount sufficient to modulate the activity of metabotropic glutamate receptors wherein: A is thiazolyl optionally substituted with 1 or 2 independent halogen, substituted or unsubstituted hydrocarbyl, substituted or unsubstituted aryl, heterocycle, mercapto, nitro, carboxyl, carbamate, carboxamide, hydroxy, ester, cyano, amine, amide, amidine, amido, sulfonyl or sulfonamide; L is alkynylene; and B is substituted or unsubstituted aryl, wherein said aryl substituents are selected from lower alkyl, lower ankenyl, lower alkynyl, hydroxy, hydroxy-lower alkynyl, lower alkoxy, lower alkenyloxy, lower akenylenedioxy, lower alkanoyloxy, phenoxy, phenyl-lower alkoxy, acyl, carboxy, esterified carboxy, amidated carboxy, cyano, nitro, amino, acylamino, N-acyl-N-lower alkylamino, halo, halo-lower alkyl, and wherein phenyl, phenyl lower alkynyl, phenoxy, and phenyl lower-alkoxy are optionally substituted.