Patent ID: 7531658

Claim:
A process for the preparation of 17-amido-3-oxo-4-azasteroid of formula 2 comprising the steps of: a) reacting in the presence of a solvent 17-carboxylic acid-3-oxo-4-azasteroid of formula 3 wherein R is selected from hydrogen, alkyl, aryl and aralkyl groups, and A is (i) —CH 2 CH 2 —, or (ii) —CH═CH— with the compound of formula 4 wherein X is C or S, to generate the compound of formula 5 wherein R and A are as defined above; and b) reacting the compound of formula 5 with an amine of formula R 1 R 2 NH, wherein R 1 and R 2 are individually selected from hydrogen, alkyl, aryl and aralkyl groups, in the presence of a heterocyclic hydroxyl activator compound.