Patent ID: 8048894

Claim:
A compound of Formula I: a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer; or a mixture of any of the foregoing, wherein: J, K, L, and M are each CR 8 ; n is 1 to 6; R 1 and R 2 are independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R 1 and R 2 can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring; R 3 and R 4 are independently selected in each instance from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R 3 and R 4 can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring; R 5 is selected from OH, SH, NH 2 , lower alkyl, substituted lower alkyl, lower alkoxy, substituted lower alkoxy, or sulfanyl; R 6 is selected from H, OH, lower alkoxy, SH, NH 2 , NHSO 2 R 9 , or sulfonyl; R 7 is selected from H, lower alkyl, or substituted lower alkyl; each R 8 is independently selected from H, F, Cl, Br, I, alkyl, substituted alkyl, haloalkyl, perhaloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, NR b R c , C(O)OR 9 , OR 9 , SR 9 , SO 2 R 9 , CN, NO 2 , aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, alkoxycarbonyl, substituted alkoxycarbonyl, or —Y—R 10 , wherein: Y is selected from —N(R 11 )—Z— or —Z—N(R 11 )—; Z is selected from C(O), SO 2 , alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, or substituted alkynylene; R 9 is selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl; R 10 is selected from H, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 11 is selected from H, lower alkyl, or substituted lower alkyl; and R b and R e are independently selected from H, lower alkyl, substituted lower alkyl, lower haloalkyl, or substituted lower haloalkyl, or R d and R e can join together to form a 3 to 6 membered ring or a substituted 3 to 6 membered ring, wherein: the term “heteroaryl” refers to 5 to 10 membered aromatic rings that include 1 to 3 heteroatoms independently selected from N, O, or S; the term “heterocyclyl” refers to a saturated or unsaturated, but not aromatic, 3 to 6 membered ring in which 1 or 2 carbon atoms (and any associated hydrogen atoms) are independently replaced with a heteroatom selected from N, O, or S; the term “heteroarylalkyl” refers to an acyclic alkyl group in which one of the hydrogen atoms bonded to a carbon atom is replaced with a heteroaryl group; and the term “heterocyclylalkyl” refers to an alkyl group in which one of the hydrogen atoms of the alkyl is replaced with a bond to a heterocyclyl group.