Patent ID: 8877759

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring D is isoxazolyl or oxadiazolyl; Ring A is a 5-6 membered monocyclic aryl or heteroaryl ring, wherein said heteroaryl ring has 1 heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur; J is halo or C 1-6 alkyl or C 1-4 alkoxy; J 1 is —(X) q —Y; X is C 1-6 alkyl wherein 0-2 methylene units of said C 1-6 alkyl are replaced with NH, O, or S; X is optionally substituted with 1-2 occurrences of C 1-3 alkyl or halo; Y is hydrogen, C 1-4 alkyl, or a 3-7 membered saturated or partially unsaturated heterocyclyl having 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; wherein the heterocyclyl is optionally substituted with 1 occurrence of halo or C 1-3 alkyl; or J and J 1 join together to form a 5-7 membered heterocyclyl having 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; wherein the heterocyclyl is optionally substituted with 1 occurrence of halo or C 1-3 alkyl; p is 0, 1, or 2; q is 0 or 1; J 2 is H or C 1-6 alkyl; J 3 is H or C 1-6 alkyl; or J 2 and J 3 join together to form a 3-7 membered monocyclic saturated ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; wherein said monocyclic ring is optionally substituted with 1-2 occurrences of halo or C 1-3 alkyl; J 4 is CN, OH, or L-Z; J 5 is H or fluoro; L is C(O), S(O) 2 , or C(O)NR; Z is (U) t- Q or C 1-6 alkyl wherein 0-2 methylene units of said C 1-6 alkyl are replaced with O or NR; U is C 1-2 alkyl; t is 0 or 1; Q is a C 3-6 cycloalkyl or a 4-6 membered saturated or partially saturated heterocyclyl having 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; and R is H or C 1-4 alkyl.