Patent ID: 8173645

Claim:
A compound having the formula: or a polymorph, tautomer, enantiomer, or pharmaceutically acceptable salt thereof, wherein X 1 is CO; X 2 is CH 2 ; X 3 is S; R 1 is wherein represents a point of attachment; R 2 is selected from the group consisting of (C 1-10 )alkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, tetrahydrofuranyl-(C 1-5 )alkyl, furanyl-(C 1-5 )alkyl, tetrahydro-2H-pyranyl-(C 1-5 )alkyl, and benzyl, each unsubstituted or substituted with halo, cyano, hydroxy, (C 1-10 )alkoxy, amino, (C 1-10 )alkylamino, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, and (C 1-10 )alkyl optionally substituted with oxo; R 3 , R 4 , R 5 , R 6 and R 7 are each hydrogen; R 12 and R 13 are each independently selected from the group consisting of hydrogen, halo, and (C 1-5 )alkyl; and R 18 is selected from the group consisting of amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, (C 1-10 )oxoalkyl, benzyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 1-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each unsubstituted or substituted with halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, and (C 1-10 )azaalkyl; and each heteroatom is independently selected from the group consisting of nitrogen, oxygen and sulfur.