Patent ID: 8536301

Claim:
An integrin binding peptide, comprising (i) a sequence binding to at least one of α v β 5 integrin, α v β 3 integrin and α 5 β 1 integrin, and (ii) a knottin protein scaffold, said sequence being comprised in said knottin protein scaffold and being an engineered integrin binding loop of 11 amino acids comprising the sequence RGD, wherein said RGD is in the sequence X 1 X 2 X 3 RGDX 7 X 8 X 9 X 10 X 11 , wherein each X represents any amino acid as provided in (iii), wherein, (iii) the knottin protein scaffold is EETI-II, and said integrin binding peptide has a sequence at least 90% identical to a peptide of one of SEQ ID NO: 23 through SEQ ID NO: 52, inclusive.