Patent ID: 8859490

Claim:
A peptide nucleic acid monomer defined by the general structural formula (I): wherein Q is an aliphatic bridge having a main chain of a length from 2 to 12 carbon atoms, optionally comprising 1 or 2 heteroatoms selected from N, O, S, Se and Si, R 2 is one of a removable amino-protecting group, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, an arylalicyclic group, a silyl-group or H, A is one of —COOH, —COOR 3 , —COX, —COSR 3 , —CN, —CONH 2 , —CONHR 3 , or —CONR 3 R 4 , wherein R 3 , and in —CONR 3 R 4 R 4 , are independently selected from the group consisting of H, and an aliphatic, alicyclic, aromatic, arylaliphatic, and arylalicyclic group comprising 0 to 3 heteroatoms selected from N, O, S, Se and Si, and X in —COX is a halogen atom, and E is a nucleobase, and Z is a polar head group.