Patent ID: 8624023

Claim:
A process of for the preparation of a pyridone compound of formula (AA), (BB) or (CC): comprising the steps of: P-1) brominating a compound of the following formula (I-I) to produe a bromine compound of the following formula (II-II): wherein R is —CHO, —CH(OH) 2 , —CH(OH)(OR 4 ), —CH(OH)—CH 2 OH or —CH(OR 5 )(OR 6 ); P 1 is H or a hydroxyl protecting group; P 3 is H or a carboxy protecting group; R 4 is lower alkyl; R 5 and R 6 are independently lower alkyl or R 5 and R 6 can be alkyl and joined to form a 5-, 6-, or 7-membered ring, and P-2) creating the 2,4-di-fluorophenyl-CH 2 —NH—C(O)— sidechain with the reactants 2,4-di-fluorophenyl-CH 2 —NH 2 and carbon monoxide.