Patent ID: 8076345

Claim:
A compound according to formula 1: wherein R 1 is aryl or heteroaryl unsubstituted or substituted with one or more R 4 groups; R 2 is H, substituted or unsubstituted C 1 -C 6 alkyl or cycloalkyl; each R 3 and R 4 is independently selected from the group consisting of H, alkyl, acyl, acylamino, alkylamino, alkylthio, alkoxy, alkoxycarbonyl, alkylarylamino, arylalkyloxy, arylalkyloxy, amino, aryl, arylalkyl, —SO 3 H, —SO 3 R 61b , wherein R 61b is a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, —S(O 2 )R 61 , wherein R 61 is a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, —SOR 61a , wherein R 61a is a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl, —SR, wherein R is a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl, azido, carbamoyl, carboxyl, cyano, cycloalkyl, cycloheteroalkyl, dialkylamino, halo, heteroaryloxy, heteroaryl, heteroalkyl, hydroxy, nitro, and SH; and m is 1, 2, 3, or 4; or a pharmaceutically acceptable salt, tautomer or isotopic variant thereof.