Patent ID: 8541596

Claim:
A compound of formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomers thereof wherein: X represents a bond or a —(CH 2 ) m -group; m represents an integer selected from 1 to 3; R 1 represents -aryl, —C 1-6 alkylaryl, -cycloalkyl, —C 1-6 alkylcycloalkyl, —C 1-6 alkyl-Het, -aryl fused to heterocyclyl, —C 1-6 alkylaryl fused to heterocyclyl, -aryl substituted by heteroaryl, —C 1-6 alkylaryl substituted by heteroaryl, -aryl substituted by phenyl, —C 1-6 alkylaryl substituted by phenyl, -aryl substituted by phenoxy or —C 1-6 alkylaryl substituted by phenoxy; and in which any of aforesaid aryl, heterocyclyl, heteroaryl, phenyl or phenoxy groups may optionally be substituted by one or more groups selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —C 1-6 thioalkyl, —SOC 1-4 alkyl, —SO 2 C 1-4 alkyl, C 1-6 alkoxy-, —O—C 3-8 cycloalkyl, C 3-8 cycloalkyl, —SO 2 C 3-8 cycloalkyl, —SOC 3-6 cycloalkyl, C 3-6 alkenyloxy-, C 3-6 alkynyloxy-, —C(O)C 1-6 alkyl, —C(O)OC 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl) and —C(O)NH(C 3-10 cycloalkyl); R 2 represents -aryl, —C 1-6 alkylaryl, -cycloalkyl, —C 1-6 alkylcycloalkyl, —C 1-6 alkyl- Het, -aryl fused to heterocyclyl, —C 1-6 alkylaryl fused to heterocyclyl, -aryl substituted by heteroaryl, —C 1-6 alkylaryl substituted by heteroaryl, -aryl substituted by phenyl, —C 1-6 alkylaryl substituted by phenyl, -aryl substituted by phenoxy or —C 1-6 alkylaryl substituted by phenoxy; and in which any of aforesaid aryl, heterocyclyl, heteroaryl, phenyl or phenoxy groups may optionally be substituted by one or more groups selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —C 1-6 thioalkyl, —SOC 1-4 alkyl, —S 0 2 C 1-4 alkyl, C 1-6 alkoxy-, —O—C 3-8 cycloalkyl, C 3-8 cycloalkyl, —SO 2 C 3-8 cycloalkyl, —SOC 3-6 cycloalkyl, C 3-6 alkenyloxy-, C 3-6 alkynyloxy-, —C(O)C 1-6 alkyl, —C(O)OC 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl) and —C(O)NH(C 3-10 cycloalkyl); Het represents a bicyclic heteroaryl group; in which said bicyclic heteroaryl group may be optionally substituted by one or more groups selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —C 1-6 thioalkyl, —SOC 1-4 alkyl, —SO 2 C 1-4 alkyl, C 1-6 alkoxy-, —O—C 3-8 cycloalkyl, C 3-8 cycloalkyl, —SO 2 C 3-8 cycloalkyl, —SOC 3-6 cycloalkyl, C 3-6 alkenyloxy-, C 3-6 alkynyloxy-, —C(O)OC 1-6 alkyl, —C(O)OC 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl-, nitro, halogen, cyano, hydroxyl, —C(O)OH, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)N(C 1-4 alkyl)(C 1-4 alkyl), —C(O)NH 2 , —C(O)NH(C 1-4 alkyl) and —C(O)NH(C 3-10 cycloalkyl).