Patent ID: 7109177

Claim:
A substituted anthracycline of the formula: wherein, R 1 is an alkyl chain, a (—COCH 2 R 13 ) group, or a (C(OH)—CH 2 R 13 )group; wherein, R 13 is a hydrogen (—H) group, a hydroxyl group (—OH), a methoxy group (—OCH 3 ), an alkoxy group comprising 1–20 carbon atoms, an alkyl group comprising 1–20 carbon atoms, an aryl group comprising 1–20 carbon atoms, a fatty acyl group comprising the general structure —O—CO(CH 2 ) n CH 3 , wherein n=an integer from 1 to about 20, a fatty acyl group comprising the general structure —O—CO(CH 2 ) l (CH═CH) m (CH 2 ) n CH 3 , wherein l is an integer between 1 to 3, m is an integer between 1 and 6, and n is an integer between 1 and 9, a —OCO—(CH 2 ) n —CH 2 NH 2 , group, or a —OCO—(CH 2 ) n —CO 2 H group; wherein R 2 and R 3 are, independently of the other, a hydrogen (—H), a hydroxyl group (—OH), or a methoxy group (—OCH 3 ); R 4 is a hydrogen (—H) group, a methoxy group (—OCH 3 ), a hydroxyl group (—OH), or a halide; wherein Y 1 and Y 2 are, independently of the other, a double bonded oxygen, sulphur, or nitrogen atom; wherein Z is a —H, —OH, a —CO 2 H, or a —CO 2 R group; wherein R 7 , R 8 , are, independently, —H, —OH, a halide, —OR 19 , —SH, —SR 19 , —NH 2 , —NHR 19 , —N(R 19 ) 2 , or —CH 3 , and R 7 can additionally be a saccharide, wherein R 19 is an alkyl chain, an alkylating moiety, a cycloalkyl chain, a cyclic ring, or a hydrogen; wherein R 9 is an —H, —CH 3 , alkyl, aryl, CH 2 OH, or, a CH 2 F group; wherein R 10 , R 11 and R 12 are, independently, —H, —OH, a halide, —OR, —SH, —SR, —NH 2 , —NHR, —N(R) 2 , or a —CH 3 ; wherein one of R 5 and R 6 is an —H; wherein one of R 5 and R 6 is a X-alkyl-aromatic-ring (—XAAR) substituent wherein, A is an alkyl group and wherein, AR is an substituted phenyl ring, a substituted five-member ring, a heteroatomic five-member ring, or a heteroatomic six-member ring, of the form: wherein at least one of R 14 –R 18 is an a (—H) group and wherein at least one of R 14 –R 18 is a hydroxyl group (—OH), a methoxy group (—OCH 3 ), a nitro group (—NO 2 ), an amine group (—NH 2 ), a halide, an alkoxy group comprising 1–20 carbon atoms, an alkyl group comprising 1–20 carbon atoms, an aryl group comprising 1–20 carbon atoms, an alkyl-amino group, an alkyl-thio group, a cyano group (CN, SCN), a —CO 2 H group, or a —CO 2 R group; and X is a —O, —N, —S, —SO, or a —SO 2 group; and A is (CH 2 ) n where n=0–10; wherein, if R 5 is a XAAR substituent R 6 is not and if R 6 is a XAAR substituent R 5 is not.