Patent ID: 8399433

Claim:
A compound of Formula 1: wherein: R1 is halogen, —CF 3 , or —CCH; at least one of Q 2 to Q 4 is >C—X 1 —R2; Q 1 and the remaining Q 2 to Q 4 are independently >CH, >CF, >N, or >N-oxide; X 1 and X 2 are independently —(CR 7 R 8 ) 0-2 —; each R 7 and R 8 is independently halogen, C 0-3 aliphatic, or —OC 0-3 aliphatic, either of which is optionally halogen substituted, except that in the case of X 2 , R 7 and R 8 are not halogen or —OC 0-3 aliphatic; R6 is halogen, —OC 0-3 aliphatic, or C 0-3 aliphatic, either optionally substituted by one or more halogen or by —OCF 3 ; R2 is —P(O)R 9 R 10 ; R 9 and R 10 are independently C 0-3 aliphatic, either of which can be taken together at any of their atoms to form a ring, wherein any of the foregoing can be further substituted by one or more halogen, C 0-6 aliphatic, or 3-6 cyclic; R is one of Q 6 , Q 7 , or A is >CR4; Q 5 and the remaining Q 6 to Q 7 and A are independently >CH, >CF, >N, or >N-oxide; R3 is C 0-6 aliphatic, —S(O) 2 R 11 , —S(O) 2 NR 11 R 12 , —C(O)NR 11 R 12 , —C(O)OR 11 ; —NR 11 S(O) 2 R 12 , or —NR 11 R 12 ; R 11 and R 12 are independently C 0-6 aliphatic, which can be taken together at any of their atoms to form a ring containing 1-3 heteroatoms; or alternatively R3 and A define any optionally substituted 5-6 cyclic containing one or more heteroatoms; R4 is 4-6 cyclic, —OC 0-6 aliphatic, or C 0-6 aliphatic, each optionally substituted, or halogen; or a pharmaceutically acceptable salt thereof.