Patent ID: 7084136

Claim:
A compound of the formula (I): A is alkylene optionally intervened with a heteroatom, optionally having an oxo group, optionally substituted with halogen and/or optionally having an unsaturated bond; R is —C(═O)—R 1 , —CH 2 —R 1 , or tetrazolyl; R 1 is hydroxy, alkyloxy, or optionally substituted amino; m is 0 or 1; provided that combinations wherein m is 1, A is —CH═CH—CH 2 —CH 2 —CH 2 — and R is —C(═O)—R 1 (R 1 is hydroxy or alkyloxy) or wherein A is —CH 2 —CH═CH—CH 2 —CH 2 —CH 2 — and R is —C(═O)—R 1 wherein R 1 is hydroxy or alkyloxy are excluded, p is 0 or 1, provided that when p=0, X 1 and X 3 are each independently optionally substituted aryl, optionally substituted heteroaryl or optionally substituted non-aromatic heterocyclyl; X 2 is a bond, —CH 2 —, —CH 2 —CH 2 —, —C(═O)—, —O—, —S—, —SO—, —SO 2 —, —NH—, —N(CH 3 )—, —C(═N—O—CH 3 )—, —N═N—, —CH═CH—, —(C═O)—NH—, —NH—(C═O)—, —CH 2 —NH—, —NH—CH 2 —, —CH 2 —O—, —O—CH 2 —, —CH 2 —S, —S—CH 2 —, —CH 2 —SO 2 —, —SO 2 —CH 2 —, —SO 2 —NH—, —NH—SO 2 —, —C(═CH 2 )—, —SO 2 N(Me)—, —CH 2 NHSO 2 —, —CH 2 NH—(C═O)—, —NH—C(═O)—NH or —NH—C(═O)—N(Me)—; X 4 is —CH 2 —, —CH 2 —CH 2 —, —C(═O)—, —SO—, —SO 2 —, —(C═O)—NH—, —NH—(C═O)—, —CH 2 —NH—, —NH—CH 2 —, —CH 2 —O—, —O—CH 2 —, —CH 2 —S—, —S—CH 2 —, —CH 2 —SO 2 —, —SO 2 —CH 2 —, —SO 2 —NH— or —NH—SO 2 —, provided that a combination wherein A is —CH═CH—CH 2 —CH 2 —CH 2 —, R is —COOH, m is 1, p is 0, X 1 and X 3 are phenyl, and X 2 is —N═N—, is excluded and provided that when X 1 and X 3 are phenyl, X 2 is —CH═CH—, —O—, or —S—, m is 0, and p is 0, a compound wherein A is —CH═CH—CH 2 —CH 2 —CH 2 —C(CH 3 ) 2 — and R is COOH, A is —CH 2 —CH═CH—CH 2 —CH 2 —C(CH 3 ) 2 — and R is COOH, A is —CH 2 —C(═O)—CH 2 —CH 2 —CH 2 —CH 2 — and R is COOH, A is —CH 2 —CH 2 —CH 2 —CH 2 —CH 2 — and R is —COOH, A is —CH 2 —CH 2 —CH 2 —CH 2 —CH 2 —CH 2 — and R is —COOH, A is —CH 2 —CH═CH—CH 2 —CH 2 —CH 2 — and R is —CH 2 OH, or A is —CH═CH—CH 2 —CH 2 —CH 2 — and R is —CH 2 OH, is excluded, a pharmaceutically acceptable salt or a solvate thereof.