Patent ID: 7192980

Claim:
A compound of formula I A is(C 1-6 )alkyl or (C 1-6 )hydroxyalkyl; B is —CH 2 CH(OR 1 )—; C is —C(R 4 )═C(R 4 )—; D is —CH═C(R 4 )CH 2 —; E is —CH(R 4 )CH═CHCH═CH 2 ; F is H, —C(O)N(R 1 ) 2 , —C(O)NHCH 2 (CH 2 ) n N(CH 3 ) 2 , or —C(O)NHCH 2 (CH 2 ) n -4-morpholino; R 1 is H, (C 1-6 )alkyl, (C 1-6 )alkyl-Ar or Ar; Ar is an aromatic or heteroaromatic ring selected from R 2 and R 3 are, independently, H, (C 1-6 )alkyl, OH, O(C 1-6 )alkyl, OCH 2 (CH 2 ) n OH, O(CH 2 ) n CO 2 H, OCH 2 (CH 2 ) n N(CH 3 ) 2 , OCH 2 (CH 2 ) n -4-morpholino, F, Cl, Br or CF 3 ; R 4 is H or (C 1-6 )alkyl; R 5 is (C 1-6 )alkyl, (C 1-6 )alkyl-Ar or Ar; m is 0 or 1; n is 1 or 2; and q is 0–6; with the proviso that when A is Ar or where each of R 4a and R 5a is (C 1-6 )alkyl, then either: B cannot be —CH 2 CH(OH)— or —CH 2 C(O)—, or C cannot be —CH═CH—, or D cannot be —CH═C(CH 3 )CH 2 —, or E cannot be —CH(CH 3 )CH═CHCH═CH 2 , or F cannot be —C(O)NH 2 , and with the provisos that when A is then B cannot be —OCH(R 4 )— or —N(R 1 )C(O)—, and when B is —CH 2 CH(OH)— or —OCH(R 4 )—, then C cannot be —OCH(R 4 )—, —N(R 1 )CH 2 — or —N(R 1 )C(O)—, and with the further proviso that the compound of formula I is not a compound of formulae or an acid or base addition salt thereof, where possible.