Patent ID: 7442762

Claim:
An analog of bacteriocidal peptide microcin J25 (MccJ25) that (1) has an amino acid sequence that differs from that of MccJ25 by having at least one amino acid substitution; and (2) that inhibits bacterial cell growth with a potency at least equal to that of MccJ25, wherein the analog is selected from the group consisting of [Ser 3 ] MccJ25 (SEQ ID NO:2), [Ile 6 ] MccJ25 (SEQ ID NO:3), [Phe 6 ] MccJ25 (SEQ ID NO:4), [Ala 11 ] MccJ25 (SEQ ID NO:5), [Trp 11 ] MccJ25 (SEQ ID NO:6), [Thr 12 ] MccJ25 (SEQ ID NO:7), [Ser 12 ] MccJ25 (SEQ ID NO:8), [Met 12 ] MccJ25 (SEQ ID NO:9), [His 12 ] MccJ25 (SEQ ID NO:10) [Leu 13 ] MccJ25 (SEQ ID NO:11), [Ala 13 ] MccJ25 (SEQ ID NO:12), [Asn 13 ] MccJ25 (SEQ ID NO:13 [Arg 13 ] MccJ25 (SEQ ID NO:14), [Pro 13 ] MccJ25 (SEQ ID NO:15), [Thr 13 ] MccJ25 (SEQ ID NO:16), [His 13 ] MccJ25 (SEQ ID NO:17), [Val 13 ] MccJ25 (SEQ ID NO:18), [Met 13 ] MccJ25 (SEQ ID NO:19), [Phe 13 ] MccJ25 (SEQ ID NO:20), [Trp 13 ] MccJ25 (SEQ ID NO:21), [Ser 14 ] MccJ25 (SEQ ID NO:22), [Thr 14 ] MccJ25 (SEQ ID NO:23), [Phe 15 ] MccJ25 (SEQ ID NO:24), [Gly 15 ] MccJ25 (SEQ ID NO:25), [Leu 15 ] MccJ25 (SEQ ID NO:26), [His 15 ] MccJ25 (SEQ ID NO:27), [Asn 15 ] MccJ25 (SEQ ID NO:28), [Ala 15 ] MccJ25 (SEQ ID NO:29), [Ile 15 ] MccJ25 (SEQ ID NO:30), [Trp 15 ] MccJ25 (SEQ ID NO:31), [Met 15 ] MccJ25 (SEQ ID NO:32), [Gln 16 ] MccJ25 (SEQ ID NO:33), [Glu 17 ] MccJ25 (SEQ ID NO:34), [Val 17 ] MccJ25 (SEQ ID NO:35) and combinations thereof.