Patent ID: 8722053

Claim:
An immunogen comprising at least one antigenic IgE peptide, a peptide linker, and an immunogenic carrier, wherein: (i) said antigenic IgE peptide consists of the amino acid sequence of SEQ ID NO:312; (ii) said peptide linker is joined at the C-terminus of the antigenic IgE peptide and is selected from GGC or GC, (iii) said immunogenic carrier is CRM197; (iv) said antigenic IgE peptide is individually chemically cross-linked to said immunogenic carrier via a thioether linkage using SMPH (Succinimidyl-6-[β-maleimidopropionamido]hexanoate) or BAANS (bromoacetic acid N-hydroxysuccinimide ester) as cross linker, wherein the linkage is between a lysine residue of the immunogenic carrier and the cysteine residue of the peptide linker; and (v) the molar ratio of said antigenic IgE peptide to said immunogenic carrier is in the range of 5:1 and 10:1.