Patent ID: 8318791

Claim:
A method of treating a colon cancer in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound represented by the formula: wherein: X 1 is —C(O)—; A 2 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, —S(O) 2 —R 9 where R 9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; R 8 is selected from the group consisting of alkyl, alkenyl, alkynyl, —CF 3 , alkoxy, cyano, halo, and hydroxy; R 4 is -[alkylene] p -NR 10 R 11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R 10 and R 11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, —S(O)-alkyl, —S(O)-substituted alkyl, —S(O) 2 -alkyl, —S(O) 2 -substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R 10 is hydrogen, R 11 is hydroxy, alkoxy or substituted alkoxy; R 15 is selected from the group consisting of ethyl, isopropyl, t-butyl, or phenyl; R 16 is hydrogen or methyl; R 17 is hydrogen or methyl; m 1 is an integer equal to 0, 1 or 2; or a pharmaceutically acceptable salts thereof.