Patent ID: 8445430

Claim:
A compound of the formula or pharmaceutically acceptable salt thereof, wherein R is hydrogen or R is C 3 -C 10 alkyl, (C 3 -C 7 cycloalkyl)C 0 -C 6 alkyl, (5- or 6-membered heterocycloalkyl)C 1 -C 6 alkyl, or (C 2 -C 6 alkylester)C 0 -C 4 alkyl, each of which is substituted with 0 or 1 or more substituents independently chosen from hydroxyl, halogen, cyano, amino, —COOH, —CONH 2 , oxo, C 1 -C 6 alkoxy, mono- and di-C 1 -C 6 alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 1 is a C 4 -C 8 saturated or unsaturated hydrocarbon chain that is (i) covalently bound to R 7 , where R 7 is a methine or methylene group or (ii) covalently bound to an optionally substituted cycloalkyl ring formed by R 7 and R 8 being joined to form a 3- to 7-membered optionally substituted cycloalkyl ring; Q is a bond; W is —N(R 2 )—; R 2 is independently chosen at each occurrence from hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, and (C 3 -C 7 cyclolalkyl)C 0 -C 2 alkyl, each of which is substituted with 0 or 1 or more substituted independently chosen from hydroxyl, halogen, cyano, amino, —COOH, —CONH 2 , oxo, C 1 -C 6 alkoxy, mono- and di-C 1 -C 6 alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 6 is hydrogen, halogen, hydroxyl, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, or C 1 -C 2 alkoxy; R 7 is methine or methylene group covalently bound to R 1 as stated in the definition of R 1 ; and R 8 is (a) hydrogen, or (b) C 1 -C 6 alkyl, or (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, each of which is optionally substituted; or R 7 and R 8 are joined to form a 3- to 7-membered optionally substituted cycloalkyl ring that is covalently bound to R 1 ; or T is a group of the formula: R 9 is —OR 12 or —NR 10 SO 2 R 11 ; R 10 , R 11 , and R 12 are independently at each occurrence hydrogen, or C 1 -C 6 alkyl, or (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl, each of which is optionally substituted; M is hydrogen, halogen, hydroxyl, C 1 -C 2 alkyl, or C 1 -C 2 alkoxy; n is 0; Y is O; and Z is (quinolinyl)C 0 -C 2 alkyl, wherein Z is substituted with 0 or 1 or more substituents independently chosen from halogen, hydroxyl, amino, cyano, —CONH 2 , —COOH, C 1 -C 4 alkyl, C 2 -C 4 alkanoyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, mono- and di-C 1 -C 4 alkylamino, C 1 -C 4 alkylester, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, and 0 or 1 (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl, (phenyl)C 0 -C 2 alkyl, (phenyl)C 0 -C 2 alkoxy, (5- or 6-membered heteroaryl)C 0 -C 2 alkyl, (5- or 6-membered heteroaryl)C 0 -C 2 alkoxy, each of which is substituted with 0, 1, or 2 substituents independently chosen from: halogen, hydroxyl, amino, cyano, nitro, —COOH, —CONH 2 , CH 3 (C═O)NH—, ═NOH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 hydroxyalkyl, mono- and di-C 1 -C 4 alkylamino, C 1 -C 4 alkyl ester, mono- and di-C 1 -C 4 alkylcarboxamide, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.