Patent ID: 8906633

Claim:
An antibody raised to an immunogen of structure (a), wherein the crosslinker is —X—Y—, wherein X is linked to the N atom of the indole ring and Y is linked to the accm, wherein Y is selected from the group consisting of carbonyl, amino, thio and azo, or Y is generated by reacting accm with X which is substituted with a terminal functional group selected from the group consisting of maleimide, isocyanate, isothiocyanate, aldehyde and dithiopyridine, and wherein X is —(CO) n -D-, wherein D is linked to Y, wherein n=0 or 1, and D is a C 1-10 substituted or unsubstituted straight chain alkylene or arylene moiety, and wherein accm is an antigenicity conferring carrier material, wherein the antibody has an average cross-reactivity, relative to JWH-018, of less than 0.28% to serotonin, 4-methoxypsilocin, δ-9-THC, cannabinol, 11-hydroxy-δ-9-THC, CP 47,497, 3-carboxy-N-pentyl-1H-indole, 3-carboxy-1H-indole, 3-carboxymethyl-5-hydroxy-1H-indole and 5-hydroxytryptophol; and, wherein the antibody has an average cross-reactivity, relative to JWH-018, of at least 100% to JWH-073, JWH-200, JWH-018 N-pentanoic acid metabolite (M1), JWH-018 5-hydroxyindole metabolite (M2), JWH-018 N-(5-hydroxypentyl) metabolite (M4), JWH-018 6-hydroxyindole metabolite (M5), and 1-(5-fluoropentyl)indol-3-yl-(1-naphthyl)methanone; and wherein the antibody has an average cross-reactivity, relative to JWH-018, of less than 6.78% to JWH-398.