Patent ID: 7799827

Claim:
A compound of the structure: or pharmaceutically acceptable salt, ester or salt of ester thereof; wherein R 1 is hydrogen, aliphatic, heteroaliphatic, alicyclic or aryl; R 2 is methyl; R 3 is hydrogen or halogen; R 4 is hydrogen or halogen; R 5 is hydrogen or an oxygen protecting group; R 6 is hydrogen, hydroxyl, or protected hydroxyl; n is 0-2; R is hydrogen; R 8 is hydrogen, halogen, hydroxyl, protected hydroxyl or alkyloxy; R 9 is NR 12 R 13 ; wherein R 12 and R 13 are, independently for each occurrence, hydrogen, aliphatic, heteroaliphatic, alicyclic or aryl; or a protecting group, and each of R 12 and R 13 are optionally further substituted with one or more occurrences of hydroxyl, protected hydroxyl, alkyloxy, amino, protected amino, alkylamino, aminoalkyl, or halogen, R 10 is hydroxyl, protected hydroxyl, or amino; R 11 is hydrogen; X is O, NH, or N-alkyl; Y is CHR 17 , O, CR 17 or NR 17 ; and Z is CHR 18 , C═O, or CR 18 , wherein each occurrence of R 17 and R 18 is hydrogen, or R 17 and R 18 taken together is —O—, or —CH 2 —, and Y and Z are connected by a single or double bond.