Patent ID: 8513440

Claim:
A compound of formula I, tautomcrs thereof, or a pharmaceutically acceptable salt thereof: R 1 , R 2 , R 3 and R 4 are each independently hydrogen, halogen, cyano, —OR, —NRR X , —NRS(O)R X , —NRS(O) 2 R X , —SR, —S(O)R, —S(O) 2 R, —OC(O)R, —C(O)R, —C(O)OR, —NRC(O)R X , —C(O)NRR x , —OC(O)OR, aliphatic, heteroaliphatic, acyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl or heteroarylalkyl; R 5 is hydrogen, aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl, or heteroarylalkyl; R 6 is H; R 7 and R 8 are each independently hydrogen, halogen, cyano, —OR, —NRR X , —NRS(O)R X , —NRS(O) 2 R X , —SR, —S(O)R, —S(O) 2 R, —OC(O)R, —C(O)R, —C(O)OR, —NRC(O)R X , —C(O)NRR X , —OC(O)OR, aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl, heteroarylalkyl, or a leaving group; R 9 and R 10 are each independently hydrogen, azide, —OR, —NRR X , —NRS(O)R X , —NRS(O) 2 R X , —SR, —S(O)R, —S(O) 2 R, —OC(O)R, —C(O)R, —C(O)OR, —NRC(O)R X , —C(O)NRR X , —OC(O)OR, aliphatic, heteroaliphatic, aryl, heteroaryl, alkylaryl or alkylheteroaryl; R 11 is hydrogen; V is O; W is O; X is O; Y is CH 2 ; Z represents a covalent bond, thereby X—Y—Z, together, forming —O—CH 2 —; and R and R X are independently hydrogen, aliphatic, heteroaliphatic, aryl, arylalkyl, alkylaryl, heteroaryl, alkylheteroaryl, heteroarylalkyl, acyl including acetyl, sulfonyl or a protecting group; wherein aliphatic, aryl, heteroaryl, alkylaryl, arylalkyl, heteroarylalkyl or alkylheteroaryl are optionally substituted.