Patent ID: 8143025

Claim:
An isolated polynucleotide comprising a nucleotide sequence encoding an antibody or binding fragment thereof that binds to human VEGFR-1 wherein the antibody or binding fragment thereof comprising a CDRL1 having the sequence RASQSVSSSYLA (SEQ ID NO:4), a CDRL2 having the sequence GASSRAT (SEQ ID NO:2), a CDRL3 having the sequence QQYGSSPLT (SEQ ID NO:3), a CDRH1having the sequence GFAFSSYGMH (SEQ ID NO: 11), a CDRH2 having the sequence VIWYDGSNKYYADSVRG (SEQ ID NO:12), and a CDRH3 having the sequence DHYGSGVHHYFYYGLDV (SEQ ID NO:13).