Patent ID: 7091223

Claim:
A compound of formula I or salt thereof where Q is thiazole optionally substituted with R 1 ; Z is a single bond; X 1 and X 2 together form ═O; R 1 is (1) hydrogen or R 6 , where R 6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, or aralkyl, each of which is unsubstituted or substituted with Z 1 , Z 2 and one or more groups Z 3 ; q is 1 or 2; R 2 is hydrogen, R 6 , -Z 4 -R 6 or -Z 13 -NR 7 R 8 ; R 3 is -Z 13 -NR 7 R 8 where Z 13 is —C(O)—; R 4 and R 5 (1) are each independently hydrogen or R 6 ; (2) -Z 4 -N(R 9)-Z 5 -NR 10 R 11 ; or (3) —N(R 9 )Z 4 R 6 ; R 7 is pyridinyl which is unsubstituted or substituted with Z 1 , Z 2 and one or more groups Z 3 ; R 8 , R 9 , R 10 , and R 11 (1) are each independently hydrogen or R 6 ; R 13 is (1) cyano; (2) nitro; (3) —NH 2 ; (4) —NHOalkyl; (5) —OH; (6) —NHOaryl; (7) —NHCOOalkyl; (8) —NHCOOaryl; (9) —NHSO 2 alkyl; (10) —NHSO 2 aryl; (11) aryl; (12) —Oalkyl; or (13) —Oaryl; R 14 is (1) —NO 2 ; (2) —COOalkyl; or (3) —COOaryl; Z 1 , Z 2 and Z 3 are each independently (1) hydrogen or Z 6 , where Z 6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, or cycloalkylaryl,; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (14) of the definition of Z 1 , Z 2 and Z 3 ; (2) —OH or —OZ 6 ; (3) —SH or —SZ 6 ; (4) —C(O) q H, —C(O) q Z 6 , or —O—C(O) q Z 6 ; (5) —SO 3 H, —S(O) q Z 6 ; or S(O) q N(Z 9 )Z 6 ; (6) halo; (7) cyano; (8) nitro; (9) -Z 4 -NZ 7 Z 8 ; (10) -Z 4 -N(Z 9 )-Z 5 -NZ 7 Z 8 ; (11) -Z 4 -N(Z 10 )-Z 5 -Z 6 ; (12) -Z 4 -N(Z 10 )-Z 5 -H; (13) oxo; or (14) —O—C(O)-Z 6 ; Z 4 and Z 5 are each independently (1) a single bond; (2) -Z 11 -S(O) q -Z 12 -; (3) -Z 11 -C(O)-Z 12 -; (4) -Z 11 -C(S)-Z 12 -; (5) -Z 11 -O-Z 12 -; (6) -Z 11 -S-Z 12 -; (7) -Z 11 -O—C(O)-Z 12 -; or (8) -Z 11 -C(O)—O-Z 12 -; Z 7 , Z 8 , Z 9 and Z 10 (1) are each independently hydrogen or Z 6 ; Z 11 and Z 12 are each independently (1) a single bond; (2) alkylene; (3) alkenylene; or (4) alkynylene; and Z 13 is (1) a single bond; (2) -Z 11 -S(O) q -Z12-; (3) -Z 11 -C(O)-Z 12 -; (4) -Z 11 -C(S)-Z 12 -; (5) -Z 11 -O-Z 12 -; (6) -Z 11 -S-Z 12 -; (7) -Z 11 -O—C(O)-Z 12 -; (8) -Z 11 -C(O)—O-Z 12 -; (9) —C(NR 13 )—; (10) —C(CHR 14 )–; or (11) —C(C(R 14 ) 2 )—.