Patent ID: 8569243

Claim:
A peptide comprising a peptide sequence of highly conserved regions of human Sirtuin (SIRT) proteins, of general formula (I): R 1 -(AA) n -X 1 —X 2 —X 3 —X 4 —X 5 —X 6 -(AA) p -R 2 in which, X 1 is glycine or threonine or histidine, X 2 is alanine or glutamine or glycine, X 3 is glycine or asparagine or serine, X 4 is valine or isoleucine or leucine, X 5 is serine or aspartic acid or phenylalanine, X 6 is alanine or glutamic acid or lysine, and when X 1 is glycine then X 2 is alanine and X 3 is glycine, when X 1 is threonine then X 3 is asparagine, when X 1 is histidine then X 2 is glycine, AA is any amino acid and n and p are integers between 0 and 2, R 1 is the primary amino function of the N-terminal amino acid, free or substituted by an acyl type group having either an alkyl chain from C 1 to C 30 , saturated or unsaturated, an acetyl group, or an aromatic group chosen from among a benzoyl, tosyl or benzyloxycarbonyl type group, and R 2 is the hydroxyl group of the carboxyl function of the C-terminal amino acid, free or substituted by a group chosen from among an alkyl chain from C 1 to C 30 , or an NH 2 , NHY or NYY group with Y representing an alkyl chain from C 1 to C 4 , wherein the peptide is one of the following sequences: (SEQ ID NO: 3) Leu-Val-Gly-Ala-Gly-Val-Ser-Ala-NH 2 (SEQ ID NO: 4) Gly-Ala-Gly-Val-Ser-Ala-Glu (SEQ ID NO: 5) Gly-Ala-Gly-Val-Ser-Ala-Glu-NH 2 .