Patent ID: 7858082

Claim:
A method of preparing a stabilized bulk solution of an IFN-beta protein, said method comprising the steps of: a) providing a bulk of IFN-beta protein in a buffer solution; b) adding an excipient to said bulk to form a stabilized bulk solution of IFN-beta protein, wherein said excipient is selected from the group consisting of: i) a bacteriostatic agent, ii) a surfactant, iii) an isotonicity agent, iv) an amino acid, v) an antioxidant, vi) an isotonicity agent and an antioxidant, vii) an isotonicity agent, an antioxidant and an amino acid, viii) an amino acid and an antioxidant, ix) an amino acid, an antioxidant and a surfactant, x) a bacteriostatic agent and an antioxidant, and xi) a bacteriostatic agent, an antioxidant and a surfactant; and c) incubating the bulk solution at a temperature range of 27° C. to 31° C. for about 3 hours to about 40 hours.