Patent ID: 8268780

Claim:
A method of preparing a Glucagon-Like Peptide 1 (GLP-1) compound that is soluble in aqueous solution at pH 7.4, said GLP-1 compound being referred to as a “soluble GLP-1 compound”, from the corresponding GLP-1 compound that is insoluble in aqueous solution at pH 7.4, said GLP-1 compound being referred to as an “insoluble GLP-1” compound, said method comprising the steps of: a) dissolving the insoluble GLP-1 compound in aqueous base to a pH between 9.0 and 12.5 or in aqueous acid to a pH between 1.5 and 6.5 to form a GLP-1 solution; b) neutralizing the GLP-1 solution to a pH between 6.5 and 9.0 at which no amino acid racemization of the dissolved GLP-1 compound occurs; and c) isolating soluble GLP-1 compound from the neutralized solution of step b) .