Patent ID: 8734780

Claim:
A method for treating a cardiac pacing condition, the method comprising administering to a subject in need thereof an effective amount of an isolated polynucleotide sequence, the polynucleotide sequence encoding a truncated human hyperpolarization-activated and cyclic nucleotide-gated (HCN) polypeptide having channel activity, wherein the truncated human HCN polypeptide comprises a N-terminal region truncation comprising the deletion from the N terminal amino acid up to, but not including, the amino acids of the S1α helical segment of the HCN polypeptide; wherein the truncated human HCN polypeptide begins with an amino acid residue selected from amino acid 92 up to amino acid 214 of SEQ ID NO:8; wherein the encoded truncated human HCN polypeptide comprises at least amino acids 214-723 of SEQ ID NO:8 and conservative substitutions thereof; and wherein the encoded truncated human HCN polypeptide demonstrates hyperpolarization-activated and cyclic nucleotide-gated channel activity unaltered from the wild type human HCN polypeptide.