Patent ID: 7511077

Claim:
A compound of the formula (Ar 1 â€”X 1 ) n â€”NR 1 â€”X 3 â€”NR 2 â€”X 2 â€”CR 3 (Ar 2 ) 2 (1) or a salt and conjugates thereof, wherein each Ar 1 is independently a cyclic moiety which is aromatic and carbocyclic; X 1 is a linker comprising a chain of 1-5 members; n is 1 or 2; R 1 is absent when n is 2 and when n is 1, R 1 is H, alkyl (1-8C), alkenyl (2-8C) or alkynyl (2-8C); X 3 is alkylene, alkenylene or alkynylene (2-8C); R 2 is H, X 2 is alkylene (2-6C) substituted with â•O at the carbon adjacent the nitrogen to which X 2 is bound; R 3 is H, OH or alkyl (1-4C); each Ar 2 independently comprises a phenyl ring wherein each Ar 1 and Ar 2 in formula (1) may be unsubstituted or substituted by one or more substituents selected from the group consisting of alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, alkylaryl, halo, CHF 2 , CF 3 , OCF 3 , OCHF 2 , CN, NO 2 , NR 2 , OR, SR, COR, COOR, CONR 2 , SOR, SO 2 R, SO 3 R, SONR 2 , SO 2 NR 2 , SO 3 NR 2 , NROCR, OOCR, NRSOR, NRSO 2 R, and NRSO 3 R, wherein R is H, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl or heteroforms of any of the foregoing, each of which may optionally be substituted, and wherein two R on the same N may form a 5-7 membered ring, and wherein two substituents on adjacent atoms may form a 5-7 membered ring; and wherein the chain comprised in X 1 and X 2 may be substituted by â•O, alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), halo, CHF 2 , CF 3 , OCF 3 , OCHF 2 , CN, NO 2 , NR 2 , OR, SR, COR, COOR, CONR 2 , SOR, SO 2 R, SO 3 R, SONR 2 , SO 2 NR 2 , SO 3 NR 2 , NROCR, OOCR, NRSOR, NRSO 2 R, and/or NRSO 3 R, wherein R is H or alkyl (1-8C), alkenyl (2-8C), alkynyl (2-8C), aryl, or alkylaryl or heteroforms of any of the foregoing, each of which may optionally be substituted wherein two R on the same N may form a 5-7 membered ring, and wherein two substituents on adjacent atoms may form a 5-7 membered ring.