Patent ID: 8545831

Claim:
A method of treating vascular disease selected from the set consisting of hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarction, the method comprising delivering by injection to a subject in need thereof a therapeutically effective amount of at least one biomembrane sealing agent and at least one bioactive agent, wherein the at least one biomembrane sealing agent and the at least one bioactive agent is delivered in an injectable composition to an area of the subject affected by vascular disease, wherein further the at least one biomembrane sealing agent is poly(ethylene glycol) with a molecular weight of between 1400 and 20000 Da and comprises more than 10% of the injectable composition, and the at least one bioactive agent comprises at least one neurotransmitter and receptor modulator, anti-inflammatory agent, antioxidant, anti-apoptotic agent, antiplatelet agent, anticoagulant agent, antineoplastic agent, agent that interferes with cellular division, nootropic and growth agent, modulator of lipid formation and transport, blood flow modulator or any combinations thereof, and wherein the injectable composition is incapable of forming a gel.