Patent ID: 8389516

Claim:
A method of treating a subject suffering from a bacterial infection or a community acquired bacterial pneumonia (CAPB), comprising administering to said subject an antibacterially effective amount of a compound of formula (I), or a salt or N-oxide thereof: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C 1 -C 6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C 1 -C 3 alkyl; X is —C(═O)NR 6 —, —S(O)NR 6 —, —C(═O)O—or —S(═O)O— wherein R 6 is hydrogen, optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -Cyc, or —(C 1 -C 3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CR, or CF; R 2 is a group Q 1 -[Alk 1 ] q -Q 2 -, wherein q is 0 or 1; Alk 1 is an optionally substituted, divalent, straight chain or branched C 1 -C 6 alkylene, or C 2 -C 6 alkenylene or C 2 -C 6 alkynylene radical which may contain or terminate in an ether (—O—), thioether (—S—) or amino (—NR)-link; Q 2 is an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 9 or 10 ring atoms; Q 1 is hydrogen, an optional substituent, or an optionally substituted carbocyclic or heterocyclic radical having 3-7 ring atoms; R 3 is a group Q 4 -[Alk 2 ] p -[Q 3 ] q - other than hydrogen wherein p and q are independently 0 or 1; Alk 2 is optionally substituted divalent C 1 -C 6 alkylene or C 2 -C 6 alkenylene or C 2 -C 6 alkynylene radical; Q 3 is an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 9 or 10 ring atoms; Q 4 is hydrogen, an optional substituent, or optionally substituted carbocyclic or heterocyclic ring having 3-7 ring atoms; wherein the bacterial infection or CAPB is caused by (i) a Gram positive bacteria selected from the group consisting of Staphylococci, Enterococci, Streptococci, Clostridia, Lactococci, Listeria, Propionibacteria and Mycobacteria ; (ii) a Gram negative bacteria selected from the group consisting of Haemophili, Moraxellas, Legionellas, Bacteroides, Escherichia, Helicobacter and Neisseria ; or (iii) an atypical bacteria selected from the group consisting of Chlamydophilas, Mycoplasmas and Chlamydia.