Patent ID: 7429596

Claim:
A compound of Formula I: or a pharmaceutically-acceptable salt thereof; wherein: Y is CR 5 ; Z is NR 3 R 4 , halo, H, OH, alkyl, alkyloxy, or haloalkyl; R 1a is phenyl substituted with —OH, wherein said phenyl is additionally substituted with at least one of —OH, —CN, NO 2 , C(═O)OH, —C(═O)O-alkyl, (C 1 -C 4 )alkyl, halo, haloalkyl or haloaryl; R 2 is C 1 -C 6 alkyl or C 4 -C 7 cycloalkyl, wherein said alkyl or said cycloalkyl is optionally substituted with mono- or di-alkoxy, mono- or di-halophenyl, mono- or di-(C 1-4 )alkoxy phenyl, mono- or di-(C 1-4 )alkyl phenyl, perhalo(C 1-4 )alkyl phenyl, carboxyl, tert-butyl carboxyl, phosphoryl, (C 1-6 )alkyl, (C 4-7 )cycloalkyl, indolyl, isoindolyl, pyridyl, naphthyl, pyrrolyl, imidazolyl, pyrazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, furyl, thienyl, or alkylmorpholino; R 3 and R 4 are independently H, C 1 -C 6 alkyl, tert-butyloxycarbonyl (t-Boc), morpholino(C 1 -C 4 )alkyl, carboxy(C 1 -C 3 )alkyl, (C 1 -C 4 )alkoxycarbonyl(C 1 -C 3 )alkyl, aryl, heteroaryl, aryloxy, heterocyclyl, cycloalkyl, alkenyl with the proviso that the double bond of the alkenyl is not present at the carbon atom that is directly linked to N, alkynyl with the proviso that the triple bond of the alkynyl is not present at the carbon atom that is directly linked to N, perfluoroalkyl, —S(O) 2 alkyl, —S(O) 2 aryl, —(C═O)heteroaryl, —(C═O)aryl, —(C═O)(C 1 -C 6 )alkyl, —(C═O)cycloalkyl, —(C═O)heterocyclyl, alkyl-heterocyclyl, aralkyl, arylalkenyl, —CON R 6 R 7, —SO 2 R 6 R 7 , arylalkoxyalkyl, arylalkylalkoxy, heteroarylalkylalkoxy, aryloxyalkyl, heteroaryloxyalkyl, aryloxyaryl, aryloxyheteroaryl, alkylaryloxyaryl, alkylaryloxyheteroaryl, alkylaryloxyalkylamine, alkoxycarbonyl, aryloxycarbonyl, or heteroaryloxycarbonyl; R 5 is H, —OH, halo, optionally monosubstituted (C 1 -C 6 )alkyl, optionally monosubstituted (C 1 -C 4 )alkoxycarbonyl, optionally monosubstituted (C 1 -C 4 )alkanoyl, carbamoyl, optionally monosubstituted (C 1 -C 4 )alkyl carbamoyl, phenyl, halophenyl, optionally monosubstituted (C 1 -C 4 )alkylphenyl, optionally monosubstituted (C 1 -C 4 )alkoxyphenyl, or optionally monosubstituted perhalo(C 1 -C 4 )alkylphenyl, wherein said optional substitution is (C 1 -C 4 )alkyl, OH, or halogen; R 6 and R 7 are independently H, alkyl, aryl, heteroaryl, alkylaryl, arylalkyl, heteroarylalkyl, or alkylheteroaryl.