Patent ID: 7220727

Claim:
A compound of formula (I): wherein: R 1 is thio, sulfinyl, sulfonyl, a direct bond, or C═X, wherein X is O or S; R 2 is (C 1 –C 12 )alkyl, (C 6 –C 10 )aryl (C 1 –C 12 )alkyl, heteroaryl (C 1 –C 12 )alkyl, or (C 3 –C 8 )cycloalkyl (C 1 –C 12 )alkyl; wherein any alkyl, aryl, heteroaryl, or cycloalkyl is substituted with one or more amino or hydroxy; R 3 is a direct bond or C═X, wherein X is O or S; R 4 is (C 1 –C 12 )alkyl optionally substituted with one or more NR a R b , wherein R a and R b are each independently hydrogen, (C 1 –C 12 )alkyl, or (C 6 –C 10 )aryl (C 1 –C 12 )alkyl; wherein any alkyl or aryl of R 4 , R a or R b is optionally substituted with one or more amino, hydroxy, or guanidinyl; R 5 is hydroxy, halo, or hydrogen and R 6 is a direct bond; or R 5 is (C 1 –C 12 )alkyl optionally substituted with one or more NR c R d , wherein R c and R d are each independently hydrogen, (C 1 –C 12 )alkyl, or (C 6 –C 10 )aryl (C 1 –C 12 )alkyl, wherein any alkyl or aryl of R 5 , R c or R d is optionally substituted with one or more amino, hydroxy, or guanidinyl, and R 6 is oxy, thio, or C═X, wherein X is O or S; R 7 is hydrogen, halo, or hydroxy; R 8 is hydrogen or hydroxy; and R 9 is hydrogen or hydroxy; wherein any alkyl is optionally interrupted with one or more oxy, thio, sulfinyl, or sulfonyl; and wherein any alkyl, aryl, heteroaryl, or cycloalkyl is optionally substituted on carbon with one or more halo, cyano, nitro, trifluoromethyl, hydroxy, (C 1 –C 6 )alkoxy, mercapto, oxo, thioxo, or NR e R f , wherein R e and R f are each independently hydrogen, (C 1 –C 12 )alkyl, or (C 6 –C 10 )aryl (C 1 –C 12 )alkyl; or a pharmaceutically acceptable salt thereof.