Patent ID: 6911447

Claim:
A compound, or all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, said compound having the formula: wherein A is a conformationally restricted ring system selected from the group consisting of: wherein the carbon atoms marked with an asterisk can have any stereo-chemical configuration W has the formula: R is phenyl or substituted phenyl; wherein R 2 , R 3 , and R 4 units are independently selected from the group: a) rings consisting of: i) substituted or unsubstituted aromatic carbocyclic rings, said rings selected from phenyl, benzyl, α-naphthyl or β-naphthyl; ii) substituted or unsubstituted aromatic heterocyclic rings, said rings selected from 1-quinolinyl, 2-quinolinyl, 3-quinolinyl, 4-quinolinyl, 5-quinolinyl, 6-quinolinyl, 7-quinolinyl, 8-quinolinyl, 1-imidazolyl, 2-imidazolyl, 4-imidazolyl, 1-imidazolylmethyl, 2-imidazolylmethyl, 4-imidazolylmethyl, 1-pyridinyl, 2-pyridinyl, 3-pyridinyl, or 4-pyridinyl; iii) and mixtures thereof: b) hydrogen; c) a unit selected from the group consisting of —CH 2 C(O)CH 3 , —NHC(O)CH 3 —NHC(O)CH 2 CH 3 , and —NHC(O)CH 2 CH 2 CH 3 ; d) two of R 2 ,R 3 , or R 4 can be taken together to form a ring consisting of: i) substituted or unsubstituted aromatic carbocyclic rings, said rings selected from phenyl, α-naphthyl, or β-naphthyl; ii) substituted or unsubatituted aromatic heterocyclic rings, said rings selected from 1-quinolinyl, 2-quinolinyl, 3-quinolinyl, 4-quinolinyl, 5-quinolinyl, 6-quinolinyl, 7-quinolinyl, 8-quinolinyl, 1-imidazolyl, 2-imidazolyl, 4-imidazolyl, 1-pyridinyl, 2-pyridinyl, 3-pyridinyl, or 4-pyridinyl; and c) mixtures thereof; Y is a pendant unit containing at least one heteroatom having the formula: —(CH 2 ) b —R 15 wherein R 15 contains a hetaroatom selected from nitrogen, oxygen, or mixtures thereof; the index b is from 1to 4; Z is a pendant unit, which contains an aromatic carbocyclic ring; said unit having the formula: wherein R 8 is hydrogen; R 9 is phenyl, benzyl, 1-naphthyl, 2-naphthyl, 1 -naphthylmethyl, 2-naphthylmethyl; R 10 is hydrogen, —C(X) 2 R 17 , —C(X)N(R 16 ) 2 , —N(R 16 ) 2 —N − (R 16 ) 3 D − , —C(X)N 1 (R 16 ) 3 D, and —NR 16 C(X)R 17 ; R 16 is hydrogen, or C 1 -C 10 alkyl, R 17 is C 2 -C 16 linear or branched, substituted or unsubstituted alkyl, C 1 -C 16 linear or branched, substitutod or unsubstituted alkylenearyl; X is oxygen, sulfur, and —NR 16 , D is a salt forming anion.