Patent ID: 8039486

Claim:
A compound of Formula I, including pharmaceutically acceptable salts thereof, wherein: z is Q is selected from the group consisting of R 1 is hydrogen; provided when Q is then R 2 is hydrogen, methoxy or halogen; R 3 and R 4 are hydrogen; and R 5 is selected from the group consisting of hydrogen, halogen, cyano, COOR 8 , XR 9 and B; or provided when Q is then R 2 is hydrogen, methoxy or halogen; R 3 is hydrogen; and R 4 is selected from the group consisting of hydrogen, halogen, cyano, COOR 8 , XR 9 and B; or provided when Q is then R 2 and R 3 are each hydrogen; and R 4 is selected from the group consisting of hydrogen, halogen, cyano, COOR 8 , XR 9 and B; m is 2; R 6 does not exist; R 7 is hydrogen; R 10 is selected from the group consisting of (C 1-6 )alkyl, —CH 2 CN, —CH 2 COOH, —CH 2 C(O)N R 11 R 12 , phenyl and pyridinyl; R 11 and R 12 are each independently H or (C 1-3 )alkyl; —— represents a carbon-carbon bond; A is selected from the group consisting of where Xw is the point of attachment and each member is independently optionally substituted with one group selected from the group consisting of methyl, methoxy, hydroxy, amino and halogen; —W— is R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 are each; B is selected from the group consisting of C(O)NR 11 R 12 , C(═NH)NHNHC(O)—R 10 , C(═NH)cyclopropyl, C(═NOH)NH 2 , and heteroaryl; wherein said heteroaryl is independently optionally substituted with a substituent selected from F; heteroaryl is selected from the group consisting of pyridinyl, pyrazinyl, pyrimidinyl, thiazolyl,pyrrolyl, imidazolyl, benzoimidazolyl, oxadiazolyl, pyrazolyl, tetrazolyl and triazolyl; F is selected from the group consisting of (C 1-6 )alkyl, (C 1-6 )alkoxy, cyano, COOR 8 —CONR 11 R 12 ; —CH 2 CN, —CH 2 COOH, —CH 2 C(O)N R 11 R 12 , phenyl and pyridinyl; R 8 and R 9 are independently selected from the group consisting of hydrogen and (C 1-6 )alkyl; and X is O.