Patent ID: 7777076

Claim:
A compound having formula (I), or a therapeutically acceptable salt thereof, wherein A 1 is CN, NO 2 , C(O)OH, F, Cl, Br, CF 3 , OCF 3 , CF 2 CF 3 , OCF 2 CF 3 , C(O)R 1 , C(O)OR 1 , SR 1 , C(O)NH 2 , C(O)NHR 1 , C(O)N(R 1 ) 2 , NHS(O)R 1 , SO 2 NHR 1 , S(O)R 1 , or SO 2 R 1 ; n is 1, 2 or 3; R 1 is R 2 , R 3 , R 4 or R 5 ; R 2 is alkyl, alkenyl or alkynyl; R 3 is perhaloalkyl or perhaloalkenyl; R 4 is C 1 -alkyl or C 2 -alkenyl, each of which is unsubstituted or substituted with one or two of independently selected F, Cl or Br; R 5 is C 2 -C 6 -alkyl or C 3 -C 6 -alkenyl, each of which is unsubstituted or substituted with one or two or three or four of independently selected F, Cl or Br; B 1 and X 1 taken together are alkylene, unsubstituted or substituted with ═O and having one CH 2 moiety unreplaced or replaced with CHCH, O, NH or N(alkyl); D 1 is H, alkyl or phenyl; Z 1 is Z 2 , Z 3 or Z 4 ; Z 2 is phenyl or heteroaryl, each of which is substituted with R 6 , OR 6 , SR 6 , S(O)R 6 or SO 2 R 6 ; R 6 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unsubstituted or substituted with one or two of independently selected alkyl, spiroalkyl, F, Cl, Br, I, R 7 , OR 7 , SR 7 , S(O)R 7 , or SO 2 R 7 ; R 7 is alkyl, alkenyl or alkynyl; Z 3 is phenyl or heteroaryl, each of which is substituted with cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is substituted with CHR 8 ; R 8 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unsubstituted or substituted with one or two or three of independently selected F, Cl, Br, I, OH, C(O)OH, C(O)OCH 3 , CN, NH 2 , NH(CH 3 ), N(CH 3 ) 2 , CF 3 , OCF 3 , CF 2 CF 3 or OCF 2 CF 3 ; Z 4 is phenyl or heteroaryl, each of which is substituted with phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is substituted with one or two of R 9 or OR 9 ; R 9 is alkyl, alkenyl or alkynyl, each of which is substituted with one or two of independently selected phenyl, heteroaryl cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unsubstituted or substituted with one or two or three of independently selected alkyl, alkenyl, alkynyl, F, Cl, Br, I, OH, C(O)OH, C(O)OCH 3 , CN, NH 2 , NH(CH 3 ), N(CH 3 ) 2 , CF 3 , OCF 3 , CF 2 CF 3 , OCF 2 CF 3 or R 11 ; and R 11 is phenyl or heteroaryl, each of which is unsubstituted or substituted with one or two or three of F, Cl, Br, I, OH, C(O)OH, C(O)OCH 3 , CN, NH 2 , NH(CH 3 ), N(CH 3 ) 2 , CF 3 , OCF 3 , CF 2 CF 3 , OCF 2 CF 3 .