Patent ID: 6939889

Claim:
A method for the treatment of cough in warm-blooded animals, which comprises administering to a warm-blooded animal in need thereof a therapeutically effective amount of a compound of the following formula (I) or a solvate of pharmaceutically acceptable salt thereof: wherein Y and E are a group represented by the following formula (II): wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are independently selected from hydrogen, C 1 -C 8 alkyl, C 3 -C 8 alkoxyalkyl and C 7 -C 12 aralkyl; m is an integer of from 1 to 8 and n is an integer of from 0 to 8; A is selected from ring systems selected from formulae (IV) , (V), (VI) , and (IX): where R 10 , R 11 and R 12 are independently selected from bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, sulfamyl, trifluoromethyl, C 2 -C 7 alkanoyloxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 7 alkoxycarbonyl, C 1 -C 6 thioalkyl, aryl and N(R 13 , R 14 ) where R 13 and R 14 are independently selected from hydrogen, acetyl, methanesulfonyl and C 1 -C 6 alkyl, and Z is N, where X may be a direct bond to Z when z is N, or Z may be directly bonded to R 15 when Z is N and X is not a direct bond to Z, R 15 is selected from hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cyclocalkyl, aryl and benzyl; and X is N—R 6 except when Z in A is nitrogen and X is a direct bond to Z; An − is the acid addition salt of a pharmaceutically acceptable acid or the anion from a pharmaceutically acceptable salt, and isolated enantiomeric, diastereomeric and geometric isomers thereof, and mixtures thereof, or a pharmaceutical composition comprising an effective amount of a compound of formula (I) and a pharmaceutically acceptable carrier, diluent or excipient.