Patent ID: 8128940

Claim:
A modified Clostridial toxin comprising: a) a Clostridial toxin enzymatic domain that executes an enzymatic target modification step of a Clostridial toxin intoxication process; b) a Clostridial toxin translocation domain that executes a translocation step of a Clostridial toxin intoxication process; c) an enhanced targeting domain comprising a Fibroblast Growth Factor (FGF) β-trefoil domain that selectively binds a Fibroblast Growth Factor Receptor-3 (FGFR3); and d) a protease cleavage site; wherein cleavage of the protease cleavage site converts the single-chain form of the modified Clostridial toxin into the di-chain form; wherein the modification is a substitution of a Clostridial toxin β-trefoil domain with the Fibroblast Growth Factor (FGF) β-trefoil domain; and wherein the modified Clostridial toxin exhibits enhanced binding activity for an endogenous Clostridial toxin receptor system relative to the binding activity of a Clostridial toxin without the modification.