Patent ID: 7576192

Claim:
An array of biosensors useful for determining the activity of nucleic acid binding protein coregulators comprising at least two biosensors, wherein each of said biosensors comprises a first nucleic acid component, a second nucleic acid component and a nucleic acid binding factor, wherein a. the first nucleic acid component comprises a portion of a nucleic acid binding element and the second nucleic acid component comprises a portion of the same nucleic acid binding element wherein the combination of both the first and second nucleic acid components comprises the nucleic acid binding element; and b. the first nucleic acid component is attached to a solid substrate and the second nucleic acid is attached to a detectable label, wherein the label is detected upon binding of the nucleic acid binding factor to the first and second nucleic acid components, to form the nucleic acid binding element, said binding being enhanced or disrupted by the nucleic acid binding protein coregulator.