Patent ID: 6864268

Claim:
A compound of Formula (I) wherein Ar is pyridyl; R 1 and R 2 are each independently hydrogen, hydroxy, halogen, cyano, nitro, —NR 1a R 2a , —NR 1a SO 2 R 2a , —OR 1a , —SO 2 R 2a , —CF 3 , (C 3 -C 8 )cycloalkyl, phenyl, —NR 1a COR 2a , —COR 2a , or (C 1 -C 6 )alkyl optionally substituted with one or more substituents selected from the group consisting of hydroxy, nitro, halogen, and cyano, where R 1a and R 2a are each independently hydrogen, (C 3 -C 8 )cycloalkyl, phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of halo, (C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy, or (C 1 -C 6 )alkyl optionally substituted with 1 to 3 substituents selected from the group consisting of hydroxy, fluoro, —CO 2 H, phenyl, and —NR 1b R 2b , where R 1b and R 2b are each independently hydrogen, amino, amino(C 1 -C 6 )alkyl, aminoaryl, (C 1 -C 6 )alkyl optionally substituted with one or more substituents selected from the group consisting of hydroxy, (C 1 -C 6 )alkoxy, fluoro, amino, (C 1 -C 6 )alkylamino, and acyl, or (C 3 -C 8 )cycloalkyl optionally substituted with one or more substituents selected from the group consisting of fluoro, alkyl, (C 1 -C 6 )alkoxy, hydroxy, amino, aminoalkyl-, acyl, and amido; R 3 and R 4 are each, independently, hydrogen, or (C 1 -C 6 )alkyl optionally substituted with 1 to 3 substituents selected from the group consisting of hydroxy, (C 1 -C 6 )alkoxy, and fluoro; R 5 is hydrogen, (C 1 -C 6 )alkyl optionally substituted with 1 to 3 substituents selected from the group consisting of hydroxy, (C 1 -C 6 )alkoxy, and fluoro; R 6 and R 7 are each independently hydrogen, halogen, or (C 1 -C 6 )alkyl optionally substituted with one or more substituents selected from the group consisting of hydroxy, (C 1 -C 6 )alkoxy, or fluoro; R 8 is —CONR 1b R 2b , —SOR 1b , —SO 2 R 1b , —SO 2 NR 1b R 2b , —NR 1b SO 2 R 2b , or —CO 2 R 1b ; R 9 is hydrogen, halogen, (C 1 -C 6 )alkoxy, or (C 1 -C 6 )alkyl optionally substituted with one or more substituents selected from the group consisting of fluoro, hydroxy, and (C 1 -C 6 )alkoxy; X is —O; m is 1; and HET is oxazole; a pharmaceutically acceptable salt thereof, a prodrug of said compound or said salt, or a solvate or hydrate of said compound, said salt or said prodrug.