Patent ID: 6967200

Claim:
A method of treating a mammal, including a human, to alleviate the pathological effects of hepatocirrhosis, which comprises administering to said mammal a pharmaceutically effective amount of a compound represented by the formula (I): wherein Ring A is represented by the formula (a) to (d): wherein R 1 and R 2 are each independently hydrogen atom, non-interfering substituent, or -(L 1 )-(acidic group) wherein L 1 is an acid linker having an acid linker length of 1 to 5, provided that one of the R 1 and R 2 is -(L 1 )-(acidic group); R 3 and R 4 are each independently hydrogen atom, non-interfering substituent, carbocyclic group, carbocyclic group substituted with a non-interfering substituent(s), heterocyclic group, or heterocyclic group substituted by a non-interfering substituent(s); and —B— is represented by the formula (e) to (h): wherein R 5 is (j) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic group, or heterocyclic group, (k) the group represented by (j) each substituted independently with at least one group selected from non-interfering substituents, or -(L 2 )- R 8 wherein L 2 is a divalent linking group of 1 to 18 atom(s) selected from hydrogen atom(s), nitrogen atom(s), carbon atom(s), oxygen atom(s), and sulfur atom(s), and R 8 is a group selected from the groups (j) and (k); R 6 is hydrogen atom, halogen, C1 to C3 alkyl, C3 to C4 cycloalkyl, C3 to C4 cycloalkenyl, C1 to C3 alkyloxy, or C1 to C3 alkylthio; R 7 is hydrogen atom or non-interfering substituent; R A is represented by the formula: wherein R 9 and R 10 are each independently hydrogen atom, C1 to C3 alkyl, or halogen; X and Y are each independently oxygen atom or sulfur atom; and Z is —NH 2 or —NHNH 2 ; R B is —CONH 2 or —CONHNH 2 ; and, Ring D is cyclohexene ring or benzene ring; provided that Ring A is (b), (c), or (d) when —B— is (e) or (f), a prodrug thereof, its pharmaceutically acceptable salt, or its solvate, together with a pharmaceutically acceptable carrier diluent or additive.