Patent ID: 8703791

Claim:
A method of reducing a gastrointestinal side effect associated with use of an opioid agent in a mammal, the method comprising administering to the mammal an opioid agent and a compound of formula (I): wherein R 1 is —OR a or —C(O)NR b R c ; R 2 , R 3 , and R 4 are each independently C 1-3 alkyl; R 5 is selected from C 1-6 alkyl, phenyl, cyclohexyl, —(CH 2 ) 1-3 -cyclohexyl, and —(CH 2 ) 1-3 -phenyl; R a , R b , and R c are each independently hydrogen or C 1-3 alkyl; and R 6 is hydrogen or C 1-3 alkyl; and wherein the substituents at the chiral centers marked by asterisks are in the trans configuration; or a pharmaceutically-acceptable salt thereof.