Patent ID: 8597659

Claim:
A method of delivering a cytokine comprising: a) obtaining a cytokine-antibody DNL complex comprising; (i) a cytokine moiety attached to a DDD (dimerization and docking domain) moiety, wherein said DDD moiety is from a dimerization and docking domain of protein kinase A and consists of the amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2; and (ii) an antibody moiety attached to an AD (anchor domain) moiety, wherein the AD moiety is from an anchoring domain of an AKAP (A-kinase anchoring protein) and consists of the amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15 and SEQ ID NO:16, wherein the DDD moieties form a dimer that binds to the AD moiety to form the complex; and b) administering the complex to a human subject.