Patent ID: 7592488

Claim:
A method of preparing a chiral amine comprising: reacting a mixture comprising an amine compound having the following Formula 1, a metal catalyst, a biocatalyst including a lipase, and an acyl donor compound having the following Formula 2 in an organic solvent to obtain a chiral amide compound having the following Formula 3; and hydrolyzing the chiral amide compound to obtain a chiral amine having the following Formula 4, wherein, wherein, in the above Formulae 1 to 4, R 1 and R 2 are connected to each other to form a ring, or are independently selected from the group consisting of hydroxyl, nitro, amino, azido, amidino, cyano, isocyano, cyanato, thiocyanato, hydrazino, hydrazono, carbonyl, carbamyl, thiocarbamyl, thiol, mesyl, a substituted or unsubstituted ester, carboxyl, or a salt thereof, sulfonic acid or a salt thereof, phosphoric acid or a salt thereof, a substituted or unsubstituted C 1 -C 15 alkyl, a substituted or unsubstituted C 2 -C 16 alkenyl, a substituted or unsubstituted C 2 -C 16 alkynyl, a substituted or unsubstituted C 6 -C 18 aryl, a substituted or unsubstituted C 7 -C 18 arylalkyl, a substituted or unsubstituted C 1 -C 20 heteroalkyl, a substituted or unsubstituted C 2 -C 20 heterocycle, a substituted or unsubstituted C 3 -C 20 heteroarylalkyl, a substituted or unsubstituted C 3 -C 15 cycloalkyl, a substituted or unsubstituted C 3 -C 15 cycloalkenyl, a substituted or unsubstituted C 6 -C 15 cycloalkynyl, a substituted or unsubstituted C 3 -C 20 heterocycloalkyl, and combinations thereof, R 3 and R 4 are independently selected from the group consisting of hydroxyl, nitro, amino, azido, amidino, cyano, isocyano, cyanato, thiocyanato, hydrazino, hydrazono, carbonyl, carbamyl, thiocarbamyl, thiol, mesyl, a substituted or unsubstituted ester, carboxyl, or a salt thereof, sulfonic acid or a salt thereof, phosphoric acid or a salt thereof, a substituted or unsubstituted C 1 -C 15 alkyl, a substituted or unsubstituted C 2 -C 16 alkenyl, a substituted or unsubstituted C 2 -C 16 alkynyl, a substituted or unsubstituted C 6 -C 18 aryl, a substituted or unsubstituted C 7 -C 18 arylalkyl, a substituted or unsubstituted C 1 -C 20 heteroalkyl, a substituted or unsubstituted C 2 -C 20 heterocycle, a substituted or unsubstituted C 3 -C 20 heteroarylalkyl, a substituted or unsubstituted C 3 -C 15 cycloalkyl, a substituted or unsubstituted C 3 -C 15 cycloalkenyl, a substituted or unsubstituted C 6 -C 15 cycloalkynyl, a substituted or unsubstituted C 3 -C 20 heterocycloalkyl, and combinations thereof, wherein R 1 has a bigger steric size than R 2 , and the metal catalyst is palladium supported on aluminum oxyhydroxide.