Patent ID: 8574576

Claim:
A method of reducing or inhibiting perfusion and permeability of a tumor which expresses EGFL7 in a subject, the method comprising administering to an individual in need of such treatment an effective amount of an anti-EGFL7 antibody, the antibody comprising a variable domain comprising the following HVR sequences: HVR-L1 comprising RTSQSLVHINXITYLH, wherein X is G or A (SEQ ID NO: 106, 241); HVR-L2 comprising RVSNRFS (SEQ ID NO: 101); HVR-L3 comprising GQSTHVPLT (SEQ ID NO: 131); HVR-H1 comprising GYTFIDYYMN (SEQ ID NO: 103); HVR-H2 comprising GDINLDNXGTHYNQKFKG (SEQ ID NO: 104, 242), wherein X is G or S; and HVR-H3 comprising AREGVYHDYDDYAMDY (SEQ ID NO: 105).