Patent ID: 7253285

Claim:
A compound of the formula: wherein R 1 is hydrogen, lower alkyl, aryloxy-lower alkyl, lower alkoxy-lower alkyl or; or R 2 —(X) n — X is lower alkylene, hydroxyloweralkylene, cycloloweralkylene, aryl lower alkylene, carboxyloweralkylene, hydroxy lower alkylene, amido lower alkylene, mono- or di-halo lower alkylene, amino lower alkylene, mono- or di-lower alkyl amino lower alkylene or imido lower alkylene; R 2 is is an aryl ring, cyclolower alkyl ring containing from 3 to 6 carbon atoms, a 4 to 6 membered heterocycloalkyl ring containing from 3 to 5 carbon atoms and from 1 to 2 hetero atoms selected from the group consisting of oxygen, nitrogen and sulfur, or a 5 or 6 membered heteroaromatic ring containing from 1 to 2 hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen; R 5 , R 6 and R 7 are independently selected from the group consisting of hydroxy, lower alkyl sulfone, hydroxy-lower alkyl, hydrogen, lower alkyl, halogen, perfluro lower alkyl, lower alkoxy, amino, mono- or di-lower alkyl amino, or when two of the substituents R 5 , R 6 and R 7 are substituted on adjacent carbon atoms on ring these two substituents can be taken together with their adjacent, attached carbon atoms to form an aryl ring, a 3 to 6 membered cyclolower alkyl ring, a 4 to 6 membered heterocycloalkyl ring or a 4 to 6 membered heteroaromatic ring, said heterocycloalkyl ring and said heteroaromatic ring containing from 1 to 2 hetero atoms selected from the group consisting of oxygen, nitrogen or sulfur; R 4 is halo, is an aryl ring, a cycloalkyl ring containing from 2 to 6 carbon atoms, a 4 to 6 membered heterocyclic alkyl ring containing from 3 to 5 carbon atoms and from 1 to 2 hetero atoms selected from the group consisting of a oxygen, sulfur and nitrogen or a 5 to 6 numbered heteroaromatic right containing from 1 to 2 hetro atoms selected from the group consisting of oxygen sulfur and nitrogen; R 8 , R 9 , R 11 , R 15 and R 16 are independently hydrogen or lower alkyl; R 10 and R 12 , are lower alkyl; R 14 is perfluro lower alkyl or —N R 15 R 16 ; R 17 and R 18 are independently hydrogen, lower alkyl, or n and k are integers from 0 to 1; m, w, y and z are integers from 0 to 3; p is an integer from 0 to 6 and v and t are integers from 1 to 6; or pharmaceutically acceptable salts thereof.