Patent ID: 8916198

Claim:
A calcium silicate composition for controlling release of a bioactive agent, the calcium silicate composition comprising: a plurality of calcium silicate (CaSiO 3 ) particles each comprising: (i) a crystalline interior portion having a network of covalently bonded silica (SiO 2 ) interrupted and modified by a plurality of calcium cations (Ca 2+ ); and (ii) an exterior surface having a layer of silica gel and having a lower calcium cation concentration than the interior portion, wherein the exterior surface is mesoporous; and a bioactive agent deposited onto the exterior surface or incorporated into the interior portion of each of the calcium silicate particles, wherein the bioactive agent is bonded to the calcium silicate particles in vitro and includes at least one of a protein, a polypeptide, a growth factor, a morphogen, an antibiotic, an antimicrobial agent, an osteoporotic drug, or a vitamin.