Patent ID: 7384736

Claim:
A method for diagnosing responders to a drug for treating a TNFα- and IL-1β-induced inflammatory disease from non-responders to the drug, comprising: a) obtaining a sample of cells from a human patient, wherein the sample is not exposed to the drug; b) optionally inducing a pro-inflammatory-like state by treating the sample with specific cytokines/mediators; c) obtaining a gene expression profile from the sample; and d) comparing the gene expression profile of the sample with a reference gene expression profile indicative of responsiveness to the drug obtained from one or more patients who are responsive to the drug and/or a reference gene expression profile indicative of non-responsiveness to the drug obtained from one or more patients who are non-responsive to the drug, wherein similarity between the sample expression profile and a reference expression profile predicts whether the patient is a responder or non-responder to the drug for treating the TNFα- and IL-1β-induced inflammatory disease.