Patent ID: 7723538

Claim:
A compound of formula (I): wherein A is —C(O)OR 1 or selected from the group consisting of tetrazol-5-yl, 5-thioxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, 2-oxo-2,3-dihydro-[1,2,3,5]oxathiadiazol-4-yl and 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl; X is —C(O)N(R 5 )—; Y 1 is C(R 6 ); Y 2 is C(R 7 ); Y 3 is C(H); Y 4 is C(R 8 ); Z 1 is C(R 9 ); R 1 is hydrogen or lower-alkyl; R 2 is hydrogen, halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy; NH 2 , N(H,lower-alkyl), N(lower-alkyl) 2 , or lower-alkyl-C(O)—O—, wherein lower-alkyl is optionally substituted with hydroxy, halogen, NH 2 , N(H,lower-alkyl), N(lower-alkyl) 2 or lower-alkoxy; R 3 is hydrogen; R 4 is 3-chloro-phenyl, 3,4-dichloro-phenyl, 3,5-dichloro-phenyl or 5-chloro-2-methoxy—phenyl; R 5 is hydrogen; R 6 , R 7 and R 8 independently from each other are selected from the group consisting of hydrogen, halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy; NH 2 , N(H,lower-alkyl), N(lower-alkyl) 2 , or lower-alkyl-C(O)—O—, wherein lower-alkyl is optionally substituted with hydroxy, halogen, NH 2 , N(H,lower-alkyl), N(lower-alkyl) 2 and lower-alkoxy; R 9 is hydrogen, halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy; NH 2 , N(H,lower-alkyl), N(lower-alkyl) 2 , or lower-alkyl-C(O)—O—, wherein lower-alkyl is optionally substituted with hydroxy, halogen, NH 2 , N(H,lower-alkyl), N(lower-alkyl) 2 or lower-alkoxy; and pharmaceutically acceptable salts and esters thereof.