Patent ID: 8372986

Claim:
A process for the formation of a 1,5-disubstituted 1,2,3-triazole or 1,4,5-trisubstituted 1,2,3-triazole, the process comprising the following steps: Step A: admixing a first compound having an acetylene group with a second compound having an azide group in a solvent for forming a reaction mixture wherein the azide group is bonded to an aliphatic carbon in the second compound; and then Step B: contacting the reaction mixture of said Step A with a quantity of ruthenium catalyst sufficient for catalyzing the formation of the 1,5-disubstituted 1,2,3-triazole or the 1,4,5-trisubstituted 1,2,3-triazole, wherein the ruthenium catalyst comprises Ru(II) bearing a cyclopentadienylic ligand; with the following provisos: if the first compound is a terminal acetylene, then the product will be a 1,5-disubstituted 1,2,3-triazole; and if the first compound is an internal acetylene, then the product will be a 1,4,5-trisubstituted 1,2,3-triazole.