Patent ID: 8624030

Claim:
A process for preparing a compound of Formula (III) from a compound of Formula (I), the process comprising: a) contacting the compound of Formula (I) with an agent that forms a ketone protecting group such that a compound of Formula (II) is formed; and b) contacting the compound of Formula (II) with an N-demethylating agent comprising LC(O)OZ and a proton acceptor to form the compound of Formula (III); wherein: R 1 and R 2 are independently chosen from hydrogen, halogen, hydroxy, amino, cyano, {—}OR 8 , hydrocarbyl, and substituted hydrocarbyl; R 3 is chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 14 is chosen from hydrogen, halogen, hydroxy, {—}OR 8 , hydrocarbyl, and substituted hydrocarbyl; R 8 and Z are independently chosen from hydrocarbyl and substituted hydrocarbyl; L is halogen; and Y is chosen from alkene acetal, dialkyl acetal, and enol ether, wherein each dashed line indicates an optional double bond.