Patent ID: 8105391

Claim:
A method of treating or ameliorating a disorder in a patient comprising implanting in the patient an implantable device, the disorder being selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof, wherein the implantable device comprises a coating comprising a PEGylated hyaluronic acid (HA) and a PEGylated non-HA polymer, wherein the PEGylated HA and the PEGylated non-HA polymer are independently modified with poly(ethylene glycol) (PEG), PEG like molecule or a combination thereof, wherein the PEG like molecule is selected from the group consisting of polyethers, polyglycols, polyalkylene oxides, and combinations thereof; wherein the PEGylated HA has a molecular weight in the range from about 70,000 Daltons to 320,000 Daltons, and wherein the PEGylated non-HA polymer is selected from the group consisting of PEGylated polyacrylates, PEGylated peptides, PEGylated proteins, and combinations thereof.