Patent ID: 7067665

Claim:
A compound of formula I, R 0 -Q-X-Q′-W-U-V-G-M (I) wherein: R 0 phenyl, wherein phenyl is unsubstituted or mono- or disubstituted independently of one another by R 2 , or pyridyl, wherein pyridyl is unsubstituted or mono-, disubstituted independently of one another by R 2 ; Q is a direct bond; X is ethylenyl; Q′ is —O—; W is phenyl or pyridyl, wherein W is unsubstituted or mono-, di- or trisubstituted independently of one another by R 1 ; U is —(CH 2 ) m —C(O)—NR 10 —(CH 2 ) n , wherein n is zero, 1 or 2, m is zero or 1, provided that Q′ and U are in a 1,3-substitution relationship with respect to each other and the 2-position is unsubstituted; V is tetrahydropyridine, pyridine, or phenyl wherein said groups are unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ; G is a direct bond, —(CH 2 ) m , —(CH 2 ) m —C(O)—NR 10 —(CH 2 ) n , —(CH 2 ) m —C(O)—(CH 2 ) n , —(CH 2 ) m —NR 10 —C(O,—NR 10− (CH 2 ) n , —(CH 2 ) m —NR 10 —C(O)—(CH 2 ) n , —(CH 2 ) m —SO 2 —NR 10 —(CH 2 ) n or —(CH 2 ) m —NR 10 —SO 2 —(CH 2 ) n , M is a pyrimidinyl group that is unsubstituted or substituted by R 14 , wherein R 1 , R 2 , and R 3 independent from each other are hydrogen, F, Cl, —O—CH 3 , —CH 3 , —C(O)—N(CH 2 —CH 3 ) 2 , —C(O)—NH 2 , or —C(O)—NH—CH 2 -piperidine-pyridine; R 4 and R 5 are independently of one another identical or different and are hydrogen atom, —(C 1 –C 6 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 , —(C 6 –C 14 )-phenyl-(C 1 –C 4 )-alkyl-, wherein alkyl and phenyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 , —(C 6 –C 14 )-phenyl-, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ; R 10 hydrogen atom or —(C 1 –C 4 )-alkyl; R 13 is halogen, —NO 2 , —CN, —OH, —(C 1 –C 8 )-alkyl, —(C 1 –C 8 )-alkyloxy, —CF 3 , —C(O)—NH 2 , —NH 2 or the residue V-G-M, wherein V, G and M are as defined above; R 14 is halogen, —OH, —NR 4 R 5 , ═O, —(C 1 –C 4 )-alkyl, —(C 1 –C 4 )-alkoxyl, —C(O)—OH, —CN, —C(O)—O—(C 1 –C 4 )-alkyl, —C(O)—NR 4 R 5 , —(C 1 –C 8 )-alkylsulfonyl, —C(O)—NH 2 , —SO 2 —NR 4 R 5 , —C(O)—NH—(C 1 –C 8 )-alkyl, —C(O)—NH—[(C 1 –C 8 )-alkyl] 2 , wherein R 4 or R 5 are as defined above; and wherein n, m, and R 10 are as defined above, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.