Patent ID: 7604952

Claim:
A method for diagnosing coronary artery disease comprising performing steps (a), (c), and (e) and at least one of steps (b) and (d): (a) obtaining one or more human samples comprising whole blood or a fluid derived from whole blood; (b) comparing a level of oxidized low density lipoprotein (OxLDL) having at least 60 aldehyde-modified lysine residues per apolipoprotein B-100 (apo B-100) moiety in one of the one or more human samples to the level of the OxLDL in a control; (c) comparing a level of malondialdehyde-modified low density lipoprotein (MDA-modified LDL) having at least 60 aldehyde-modified lysine residues per apolipoprotein B-100 (apo B-100) moiety in one of the one or more human samples to the level of the MDA-modified LDL in a control; (d) comparing a level of a heart protein that is a marker for acute myocardial infarction in one of the one or more human samples to the level of the heart protein in a control; and (e) making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (b), (c), and (d) are all performed: 1.1 Indication (b) (c) (d) the individual does not have coronary artery disease − − − the individual has chronic coronary artery disease + − − the individual has unstable angina + + − the individual has acute myocardial infarction of + + + atherosclerotic origin the individual has acute myocardial infarction of − − + non-atherosclerotic origin or making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (b) and (c) are performed: 1.2 Indication (b) (c) the individual does not have coronary artery disease − − the individual has chronic coronary artery disease + − the individual has acute coronary artery disease + + or making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (C) and (d) are performed: 1.3 Indication (c) (d) the individual does not have acute coronary artery disease − − the individual has unstable angina + − the individual has acute myocardial infarction of − + non-atherosclerotic origin the individual has acute myocardial infarction of + + atherosclerotic origin wherein “+” indicates that the level of the OxLDL, MDA-modified LDL, and heart protein in the human sample is higher compared to the level of the OxLDL, MDA-modified LDL, and heart protein in the control and “−” indicates that the level of the OxLDL, MDA-modified LDL, and heart protein in the human sample is not higher compared to the level of the OxLDL, MDA-modified LDL, and heart protein in the control, the control providing results based on those of a normal control population.