Patent ID: 7419972

Claim:
A 2-substituted estra-1,3,5(10)-trien-17-one compound of formula I in which R 2 means phenylethyl, phenylpropyl or phenylethinyl, R 13 means a hydrogen atom or a methyl group, R 16 means a hydrogen atom or a fluorine atom, Z means an oxygen atom or a sulfur atom, R 3 and R 5 mean, in each case independently of one another, an α- or β-position hydrogen atom, R 4 and R 6 mean, in each case independently of one another, an α- or β-position hydrogen atom, a C 1 -C 5 -alkyl group, a C 1 -C 5 -alkyloxy group, a C 1 -C 5 -acyl group, a hydroxy group, an aralkyl or heteroaralkyl radical, or an alkylaryl or alkylheteroaryl radical, R 3 and R 4 together can also be an oxygen atom, R 5 and R 6 together can also be an oxygen atom, R 7 and R 8 in each case mean a hydrogen atom or together a CH 2 group, wherein the aryl or heteroaryl groups are unsubstituted or substituted by methyl, ethyl, trifluoromethyl, pentafluoroethyl, trifiuoromethylthio, methoxy, ethoxy, nitro, cyano, halogen, hydroxy, amino, mono(C 1-8 -alkyl)amino, di(C 1-8 -alkyl)amino wherein the alkyl groups are identical or different, or di(aralkyl)amino wherein the aralkyl groups are identical or different, and wherein the dotted lines in the B-, C- and D-ring of the steroid skeleton additionally can be up to two double bonds, or a pharmaceutically acceptable salt thereof.