Patent ID: 7220758

Claim:
A compound of the Formula (I-2): wherein: X is —CH(R 5 )—, —CH(R 5 )-alkylene-, —CH(R 5 )-alkenylene-, or CH(R 5 )-alkylene-Y-alkylene-; R 1-2 is selected from the group consisting of: —R 6 —N(R 9 )—SO 2 —R 8 -alkyl; —R 6 —N(R 9 )—SO 2 —R 8 -alkenyl; —R 6 —N(R 9 )—SO 2 —R 8 -aryl; —R 6 —N(R 9 )—SO 2 —R 8 -heteroaryl; —R 6 —N(R 9 )—SO 2 —R 8 -heterocyclyl; —R 6 —N(R 9 )—SO 2 —R 10 ; —R 6 —N(R 9 )—SO 2 —N(R 5 )—R 8 -alkyl; —R 6 —N(R 9 )—SO 2 —N(R 5 )—R 8 -alkenyl; —R 6 —N(R 9 )—SO 2 —N(R 5 )—R 8 -aryl; —R 6 —N(R 9 )—SO 2 —N(R 5 )—R 8 -heteroaryl; —R 6 —N(R 9 )—SO 2 —N(R 5 )—R 8 -heterocyclyl; and —R 6 —N(R 9 )—SO 2 —NH 2 ; R 2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -alkylene-Y-alkyl; -alkylene-Y-alkenyl; -alkylene-Y-aryl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: —OH; -halogen; —N(R 5 ) 2 ; —C(O)—C 1-10 alkyl; —C(O)—O—C 1-10 alkyl; —N 3 ; -aryl; -heteroaryl; -heterocyclyl; —C(O)-aryl; and —C(O)-heteroaryl; Y is —O— or —S(O) 0-2 —; R 3 and R4 are independently selected from the group consisting of hydrogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 alkoxy, C 1-10 alkylthio, amino, alkylamino, dialkylamino, halogen, and nitro; each R 5 is independently hydrogen, C 1-10 alkyl, or C 2-10 alkenyl; R 6 is alkylene, alkenylene, or alkynylene, which may be interrupted by one or more —O— groups; R 8 is a bond, alkylene, alkenylene, or alkynylene which may be interrupted by one or more —O— groups; R 9 is hydrogen, C 1-10 alkyl, or arylalkyl; or R 9 can join together with any carbon atom of R 6 to form a ring of the formula R 10 is hydrogen or C 1-10 alkyl; or R 9 and R 10 can join together to form a ring selected from R 12 is C 2-7 alkylene which is straight chain or branched, wherein the branching does not prevent formation of the ring; or a pharmaceutically acceptable salt thereof.