Patent ID: 8497287

Claim:
A method of treating a mammal having a medical condition ameliorated by treatment with a mu opioid receptor antagonist wherein the medical condition is opioid-induced bowel dysfunction or post-operative ileus, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein R 1 is —OR a or —C(O)NR b R c ; R 2 , R 3 , and R 4 are each independently C 1-3 alkyl; R 5 and R 6 are each independently selected from hydrogen, benzyl, and phenyl, wherein phenyl is optionally substituted with halo, or R 5 and R 6 together with the carbon atom to which they are attached form a cyclopentyl or cyclohexyl ring, R 7 is selected from hydroxy, C 1-3 alkoxy, and —NR 8 R 9 ; R 8 and R 9 are each independently selected from hydrogen, C 1-6 alkyl, cyclohexyl, and benzyl, or R 8 and R 9 together with the nitrogen atom to which they are attached form piperidinyl or piperazinyl, wherein piperidinyl and piperazinyl are optionally substituted with methyl; R a , R b , and R c are each independently hydrogen or C 1-3 alkyl; n is 0, 1, 2, 3, or 4; and m is 0 or 1; wherein the substituents at the chiral centers marked by asterisks are in the trans configuration; provided that when n+m=1 and R 7 is hydroxy or C 1-3 alkoxy, then R 5 and R 6 are each independently selected from benzyl and phenyl or R 5 and R 6 together with the carbon atom to which they are attached form a cyclohexyl ring; or a pharmaceutically-acceptable salt thereof.