Patent ID: 7635706

Claim:
A compound of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof, wherein —R 1 —R 2 — is a bivalent radical of formula —O—CH 2 —CH 2 —CH 2 —O— (a-5), wherein in said bivalent radicals optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C 1-6 alkyl or hydroxy, R 3 is halo; R 4 is halo; R 5 is hydrogen or C 1-6 alkyl, and the —OR 5 radical is situated at the 3- or 4-position of the piperidine moiety; L is hydrogen, or L is a radical of formula -Alk-R 6 (b-1), -Alk-X—R 7 (b-2), -Alk-Y—C(═O)—R 9 (b-3), or -Alk-Z-C(═O)—NR 11 R 12 (b-4), wherein each Alk is C 1-12 alkanediyl; and R 6 is hydrogen; hydroxy; cyano; C 3-6 cycloalkyl; C 1-6 alkylsulfonylamino; aryl or Het; R 7 is C 1-6 alkyl; C 1-6 alkyl substituted with hydroxy; C 3-6 cycloalkyl; aryl or Het; X is O, S, SO 2 or NR 8 ; said R 8 being hydrogen or C 1-6 alkyl; R 9 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, hydroxy or aryl; Y is a direct bond, or NR 10 wherein R 10 is hydrogen or C 1-6 alkyl; Z is a direct bond, O, S, or NR 10 wherein R 10 is hydrogen or C 1-6 alkyl; R 11 and R 12 each independently are hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or R 11 and R 12 combined with the nitrogen atom bearing R 11 and R 12 may form a pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring both being optionally substituted with C 1-6 alkyl; aryl represents unsubstituted phenyl or phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylcarbonyl, nitro, trifluoromethyl, amino, aminocarbonyl, and aminosulfonyl; and Het is furanyl; furanyl substituted with C 1-6 alkyl or halo; tetrahydrofuranyl; tetrahydrofuranyl substituted with C 1-6 alkyl; dioxolanyl; dioxolanyl substituted with C 1-6 alkyl; dioxanyl; dioxanyl substituted with C 1-6 alkyl; tetrahydropyranyl; tetrahydropyranyl substituted with C 1-6 alkyl; 2,3-dihydro-2-oxo-1H-imidazolyl; 2,3-dihydro-2-oxo-1H-imidazolyl substituted with one or two substituents each independently selected from halo, or C 1-6 alkyl; pyrrolidinyl; pyrrolidinyl substituted with one or two substituents each independently selected from halo, hydroxy, or C 1-6 alkyl; pyridinyl; pyridinyl substituted with one or two substituents each independently selected from halo, hydroxy, C 1-6 alkyl; pyrimidinyl; pyrimidinyl substituted with one or two substituents each independently selected from halo, hydroxy, or C 1-6 alkyl; pyridazinyl; pyridazinyl substituted with one or two substituents each independently selected from hydroxy, C 1-6 alkyloxy, C 1-6 alkyl or halo; pyrazinyl; pyrazinyl substituted with one ore two substituents each independently selected from hydroxy, C 1-6 alkyloxy, C 1-6 alkyl or halo.