Patent ID: 8841257

Claim:
A compound of structural Formula I or a salt, ester or drug thereof, wherein: X is selected from the group consisting of O, CH 2 , CF 2 , any of which may be optionally substituted; Y is a dipeptide mimic selected from the group consisting of Haic (5-(amino)-1,2,4,5,6,7-hexahydro-4-oxo-(2S,5S)-azepino[3,2,1-hi]indole-2-carboxylic acid), or a dipeptide of the structure Aaa-Bbb in which Aaa is norleucine, leucine, or homophenylalanine and Bbb is proline, (2S,3R,4S)-cis-3,4-methanoproline, 4,4-difluoroproline, 4,4-dimethylproline, 4-hydroxyprolin, any of which may be optionally substituted; Z is selected from the group consisting of CH 2 , NH, or O, any of which may be optionally substituted; R 1 is selected from the group consisting of a phenyl substituted group with one or more of the following: H, CH 3 , F, CI, Br, OCOCH 3 , NO 2 , or CN; pivaloyloxymethyl; benzoyloxymethyl; benzoyloxymethyl in which the phenyl group is substituted with one or more of the following: H, CH 3 , F, CI, Br, OCOCH 3 , or NO 2 ; acetoxybenzyl; 2-pyridyl; 3-pyridyl; 4-pyridyl; or acyloxymethyl in which the acyl group possesses aliphatic or polyethylene glycol groups, CH 2 OCO(CH 2 CH 2 O) n CH 2 CH 3 in which n≧1, CH 2 OCO(CH 2 CH 2 O) n CH 3 in which n≧1, any of which may be optionally substituted; R 2 is selected from the group consisting of H or CH 3 , any of which may be optionally substituted; and R 3 is selected from the group consisting of H, CH 3 , CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH 3 , CH 2 C 6 C 4 OH(para), CH 2 OCH 2 C 6 H 5 , CH(CH 3 )OCH 2 C 6 H 5 , CH 2 OH, CH 2 OCOCH 3 , CH(CH 3 )OH, CH 2 OCO(CH 2 CH 2 O) n CH 3 n=1-50, 1-piperidinomethyl, 4-morpholinomethyl, 1-methyl-4-piperazinomethyl, CH 2 NH 3 , CH 2 NHCOCH 3 , CONHCH 2 C 6 H 5 , any of which may be optionally substituted, and when R 1 is pivaloyloxymethyl, R 2 is not H and/or R 3 is not CONHCH 2 C 6 H 5 .