Patent ID: 8410091

Claim:
A process of preparing a compound of formula (I) or a salt thereof, wherein R 1 is a heterocycle selected from the group consisting of: R 2 is selected from H, F, Cl, CN, CF 3 , (C 1-6 )alkyl, (C 3-12 )cycloalkyl and —O—(C 1-6 )alkyl; R 3 is selected from H, F, Cl, CN, (C 1-6 )alkyl, —OH, —O—(C 1-6 )alkyl, S—(C 1-6 )alkyl, —NH 2 , —NH(C 1-6 )alkyl, —NH(C 3-12 )cycloalkyl, —N((C 1-6 )alkyl (C 3-12 )cycloalkyl) and —N((C 1-6 )alkyl) 2 ; R 4 and R 5 are each independently selected from H, (C 1-6 )alkyl, (C 3-12 )cycloalkyl and oxo (C(═O)); R 6 , R 7 , and R 8 are each independently selected from H, F, Cl, (C 1-6 )alkyl, and (C 3-12 )cycloalkyl; R 9 is selected from H, F, Cl, (C 1-6 )alkyl, and (C 3-12 )cycloalkyl; R 10 is selected from H, (C 1-6 )alkyl, and (C 3-12 )cycloalkyl; wherein each of R 1 to R 10 is optionally substituted by one or more substituents selected from H, F, Cl, CF 3 , OXO, (C 1-6 )alkyl, (C 3-12 )cycloalkyl, (C 1-6 )alkyl(C 3-12 )cycloalkyl, —OH, —SH, —O(C 1-6 )alkyl, —S(C 1-6 )alkyl, —NH 2 , —NH(C 1-6 )alkyl and aryl; comprising: Step A: converting a compound of formula (II) to a compound of formula (III) according to reaction scheme 1: wherein the compound of Formula (II) is first reacted with methylsulfonyl chloride in the presence of a suitable solvent and at a suitable reaction temperature; upon quenching of the reaction and partially or completely removal of the solvent, the resulting mesylate intermediate is reacted with an optionally-brominated R 1 in the presence of a suitable base, a suitable solvent and at a suitable reaction temperature to provide the compound of formula (III) wherein m is an integer from 0 to 3 and R 11 is a halo; Step B: converting the compound of formula (III) to a compound of formula (V) according to reaction scheme 2: wherein the compound of formula (III) is reacted with a compound of formula (IV) or a salt thereof in the presence of a suitable base, a suitable solvent and at a suitable reaction temperature to provide the compound of formula (V); and Step C: converting the compound for formula (V) to a compound of formula (I) according to reaction scheme 3: wherein the compound of formula (V) is hydrogenated in the presence of a suitable catalyst, a suitable solvent and at a suitable reaction temperature to provide a compound of formula (I).