Patent ID: 6875784

Claim:
A compound of Formula I wherein: A is a structure i, ii, iii, or iv where the dashed line in formula iii represents an optional double bond; n is 0 or 1; X is N or CH; Y is N, O, or S; Z is NHC(═O)R 1 , NHC(═S)R 1 , CONHR 1 , NHC(═NCN)R 1 , NH-het 1 , O-het 1 , S-het 1 or het 2 ; R 1 is H, NH 2 , NHC 1-4 alkyl, C 1-4 alkyl, C 2-4 alkenyl, (CH 2 ) m C(═O)C 1-4 alkyl, OC 1-4 alkyl, SC 1-4 alkyl, (CH 2 ) m C 3-6 cycloalkyl, CH═CH-aryl, CH═CH-het 1 , CH 2 C(═O)-aryl, or CH 2 C(═O)-het 1 ; R 2 and R 3 are independently H or F; R 4 and R 5 are independently H, Cl, F, CH 3 , NH 2 , or OH; R 6 and R 7 are independently H, F, OH, C 1-4 alkyl, or C 1-4 heteroalkyl; R 8 is H, F, OH, CN, NR 10 R 11 , C 1-4 alkyl, C 3-6 cycloalkyl, C 1-4 heteroalkyl, aryl, het 1 , OC 1-4 alkyl, C 1-4 alkylOR 10 , C 1-4 alkylNR 10 R 11 , O(C═O)C 1-4 alkyl, C(═O)C 1-4 alkyl, C(═O)OH, C(═O)NR 10 R 11 , C(═NOC 1-4 alkyl)H, C(═NOC 1-4 alkyl)C 1-4 alkyl, C(═O)het 1 , C(═NOC 1-4 alkyl)het 1 , (CH 2 ) m C(═O)NR 10 R 11 , NR 10 CONR 10 R 11 , NR 10 C(═O)C 1-4 alkyl, NR 10 C(═O)C 3-6 cycloalkyl, NR 10 C(═O)OH, NR 10 C(═O)H, or OC 1-4 alkylCONR 10 R 11 , provided that when Y is is O or S, then R 8 is absent, further wherein each R 10 and R 11 are independently H, C 1-4 alkyl, C 3-6 cycloalkyl, aryl, het 1 , C(═O)aryl, C(═O)het 1 , SO 2 C 1-4 alkyl, or SO 2 NH 2 ; het 1 is a C-linked five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen; het 2 is a N-linked or C-linked five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen; each m is independently 0, 1, or 2; and a pharmaceutically acceptable salts thereof; with the further provisos that when Z is NHC(═O)R 1 or NHC(═S)R 1 ; n is 1; A is structure (i); R 2 , R 3 , R 6 and R 7 are H; X is N; Y is N; then R 8 is not C(═O)het 1 ; and when Z is NHC(═O)R 1 or NHC(═S)R 1 ; n is 1; A is structure (i); R 2 , R 3 , R 6 and R 7 are H; X is N; Y is N; and R 8 is NR 10 R 11 or C 1-4 alkylNR 10 R 11 ; then R 10 and R 11 are not het 1 , aryl, C(═O)aryl, or C(═O)het 1 .