Patent ID: 8580490

Claim:
A method of evaluating treatment efficacy in a subject undergoing treatment for tuberculosis comprising the steps of: administering a regimen of anti-mycobacterial treatment to the subject undergoing treatment for tuberculosis; providing at least two samples from the subject undergoing treatment, wherein the first sample is taken at or before the beginning of the treatment regimen and the second sample is taken at a later time following the initiation of treatment; measuring the change between the at least two samples in a metabolomic marker selected from the group consisting of Hydroxyproline, N-Acetyl-L-aspartic acid, Dimethyl-L-arginine, N-Acetylasparagine, 1-Methylhistidine, L-Phenylalanine, 2,2,5,5-Tetramethyl-3-pyrrolidinecarboxamide, Pyroglutamic acid, Acetylcysteine, Trigonelline, S-Adenosylhomocysteine, L-Tyrosine, alpha-Aminoadipic acid, Quinolinic acid, Hypoxanthine, and Pyrroline hydroxycarboxylic acid; and correlating the measured change in the marker with a predetermined treatment efficacy.