Patent ID: 6919361

Claim:
A compound of the formula: wherein X is a sulfur atom, R 1 is a hydrogen atom, a substituted or unsubstituted alkyl, or a substituted or unsubstituted aryl, R 2 an aryl, or an aryl being substituted by one or more groups selected from the group consisting of a halogen atom, a C 1 -C 4 alkoxy, trifluoromethoxy, morpholino, or methylenedioxy, Y 1 is a direct bond, a substituted or unsubstituted alkylene, —CO(CH 2 ) n —, —SO 2 (CH 2 ) n —, —CONH(CH 2 ) n —, —CSNH(CH 2 ) n —, or —COO(CH 2 ) n —, n is an integer of from 0 to 5, the wavy line means (E)-configuration or (Z)-configuration, R 3 is a hydrogen atom, a substituted or unsubstituted aryl, or a substituted or unsubstituted cycloalkyl, Y 2 is a substituted or unsubstituted alkylene, or an alkenylene, R 4 is a substitiuted or unsubstituted alkanoyl, —COOR 8 , —SO 2 R 9 , —COR 10 , —CON(R 11 )R 12 , —CSN(R 13 )R 14 , or —C(═NH) N (R 15 )R 16 , R 5 is a hydrogen atom, or a substituted or unsubstituted alkyl, R 8 is a substituted or unsubstituted alkyl, a cycloalkyl, or a substituted or unsubstituted aryl, R 9 is a substituted or unsubstituted alkyl, or a substituted or unsubstituted aryl, R 10 is a cycloalkyl, or a substituted or unsubstituted aryl, R 11 is a hydrogen atom or an alkyl, R 12 is a hydrogen atom, a substituted or unsubstituted alkyl, a cycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted arylcarbonyl, R 13 is a hydrogen atom or an alkyl, R 14 is a hydrogen atom, a substituted or unsubstituted alkyl, a cycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted arylcarbonyl, R 15 is a hydrogen atom or an alkyl, R 16 is a hydrogen atom or a substituted or unsubstituted alkyl, or a pharmaceutically acceptable salt thereof, or a prodrug thereof.