Patent ID: 8865662

Claim:
A macrolide compound of the formula I: wherein R1 is a residue —X-Q; X is a linear group which linear group consists of hydrogen atoms and from 1 to 7 atoms selected from C, N, O and S, of which from 1 to 2 atoms can be N and one atom can be O or S, one carbon atom can appear as a CO group and the sulfur atom can appear as an SO 2 group and two adjacent C atoms can be present as —CH═CH— or —C≡C— and which linear group is unsubstituted or substituted; Q is the residue —NR6R7; W is optionally substituted aryl or heterocyclyl, A2 is either absent or a C 1 -C 4 alkylene group; L is —O—, —S—, —SO 2 —, —NH—, —CO—, —(CO)O—, —O(OC)—, —(CO)NH—, —NH(CO)—, —(SO 2 )NH—, —HN(SO 2 )—, —HN(CO)NH—, —O(CO)NH—, —NH(CO)O—, or can also be absent if A2 is present; R2 is OR2a or wherein represents the linking bond; R2a is hydrogen; R3 is hydrogen; Z is wherein represents the linking bond; R4 is —OR4a; R5 is —NR5bR5c; or R4 taken together with R5 represent a group —O(CO)NR45- R4a is hydrogen or C1-C6 alkyl which can be substituted or unsubstituted and wherein one or more single bonds can be replaced by double and/or triple bonds and where one carbon atom can appear as C═O and up to two atoms can be N, O or S; R45 is hydrogen or C1-C6 alkyl; R5b, R5c independently of one another, are hydrogen, C1-C6alkyl which can be substituted or unsubstituted, and up to two atoms of which can be N, O or S and where one carbon atom can appear as C═O, or —(C═O)heterocyclyl or, taken together with the nitrogen atom to which they are linked, form a 4-7 membered-ring of which up to two atoms can be N, O or S and one carbon can appear as C═O; R6 and R7 are independently selected from the group consisting of optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, and -L-A2-W; with the proviso that only one of R6 and R7 is -L-A2-W; wherein alkyl groups may be substituted with one or more substituents selected from the group consisting of C 1 -C 4 alkoxy, C 3 -C 7 cycloalkyloxy or C 3 -C 7 cycloalkyl-C 1 -C 4 alkoxy, halogen, halogen substituted alkyl groups, cyano, nitro, amino, alkylamino, dialkylamino, alkylthio, mercapto, hydroxy, carbamoyl, carboxyl and oxo, and provided that R5 is not a dimethylamino group; or a pharmaceutically acceptable salt, a N-oxide or an in vivo cleavable ester of said compound of formula (I).