Patent ID: 7807182

Claim:
An antigenic composition useful for early detection of M. tuberculosis (Mtb) disease or infection or for immunizing a subject against Mtb infection, comprising (a) a peptide selected from the group consisting of: (1) CGTDGAEKGPTYNKVRGDK; (SEQ ID NO: 108) (2) KIGIMDEERRTTVNLKAC; (SEQ ID NO: 109) (3) ELAWAPDEIREEVDNNC; (SEQ ID NO: 110) (4) LHRRRREFKARAAEKPAPSDRAG; (SEQ ID NO: 111) (5) ARDELQAQIDKWHRRR; (SEQ ID NO: 112) (6) LNRDRNYTAPGGGQ; (SEQ ID NO: 113) (7) GAPQLGRWKWHDPWV (SEQ ID NO: 114) (8) VGNLRIARVLYDF; (SEQ ID NO: 117) (9) QAQIDKWHRRRVI; (SEQ ID NO: 126) (10) WHRRRVIEPIDMD; (SEQ ID NO: 127) (11) IEPIDMDAYRQFL; (SEQ ID NO: 128) (12) ITTTAGPQLVVPV; (SEQ ID NO: 134) (13) PQLVVPVLNARFA; (SEQ ID NO: 135) (14) VLNARFALNAANA; (SEQ ID NO: 136) (15) ALNAANARWGSLY; (SEQ ID NO: 137) (16) ARWGSLYDALYGT; (SEQ ID NO: 138) (17) SVLLINHGLHIEI; (SEQ ID NO: 154) (18) HGLHIEILIDPES; (SEQ ID NO: 155) (19) GGQFTLPGRSLMF; (SEQ ID NO: 170) (20) FVRNVGHLMTNDA; (SEQ ID NO: 172) (21) DRVVFINTGFLDR; (SEQ ID NO: 191) (22) NCQSILGYVVRWV; (SEQ ID NO: 216) and (23) GYVVRWVDQGVGC. (SEQ ID NO: 217) with the proviso that said composition is not the full length protein GlcB, the sequence of which is SEQ ID NO:106, or MPT51, the sequence of which is SEQ ID NO:107; (b) a conservative amino acid substitution variant of the peptide of (a) which retains reactivity with antibodies specific for (i) GlcB in the case of peptides (1)-(6) or (8)-(23) or (ii) MPT51 in the case of peptide (7); or (c) a combination of two or more of any of said peptides (1)-(23) of (a) or a combination of two or more of any of said variants of (b), or a combination of any one or more of said peptides of (a) and any one or more of said variants of (b).