Patent ID: 8921336

Claim:
A compound of formula I, or pharmaceutically acceptable salt thereof: wherein X 1 is NR 1 ′, O, S, or CH; X 2 is CR 1 ; X 3 is CH; R 1 is independently selected from H; C 1-6 alkyl optionally substituted with OH or NR 15 R 16 ; (CH 2 )heterocycloalkyl, said heterocycloalkyl is a 3-8 membered monocyclic ring containing one N atom and optionally substituted with NR 15 R 16 ; —C(O)heterocycloalkyl, said heterocycloalkyl is a 3-8 membered monocyclic ring containing one or two nitrogen atoms and optionally substituted with one or more substituents independently selected from halogen, R 17 , NR 15 R 16 , C(O)OR 15 , C(O)NR 15 R 16 , OR 15 , 1-pyrrolidinyl, furan-3-ylcarbonyl, phenyl substituted with C 1 -C 2 perfluoroalkyl, or C(O)OH; C(O)OC 1-6 alkyl; C(O)NR x R x ; C(O)NHC(NH)NH 2 ; C(O)NHNHR 2 ; C(O)NHS(O) 2 R x ; or OH; R x , for each occurrence, is independently H; C 1-6 alkyl optionally substituted with morpholinyl, OR 15 , or NR 15 R 16 ; heterocycloalkyl, said heterocycloalkyl is a 3-8 membered monocyclic ring containing one nitrogen atom and optionally substituted with R 17 or benzyl; phenyl substituted with R 17 or C 1 -C 2 perfluoroalkyl, and optionally arylalkylamino, wherein the arylalkyl is benzyl substituted with ═O and C 1 -C 2 perfluoroalkyl; or R 1 ′ is selected from H; C 1-6 alkyl optionally substituted with one OH; (CH 2 ) n heterocycloalkyl, said heterocycloalkyl is a 3-8 membered monocyclic ring containing one to two heteroatoms selected from N or O and optionally substituted with one or more substituents independently selected from OH or R 17 ; (CH 2 )aryl, said aryl is a phenyl optionally substituted with OR 15 ; or (CH 2 ) n C(O)NR y R y ; R y , for each occurrence, is independently H; or C 1-6 alkyl optionally substituted with OR 15 or a morpholinyl; R 2 is C 1-4 alkyl; R 15 is H or C 1-6 alkyl; R 16 is H or C 1-4 alkyl; R 17 is C 1-4 alkyl optionally substituted with OH or C 1-4 alkoxy; Y is H; m is 1 or 2; and each n is independently 0, 1 or 2; wherein when m=1, then X 1 can only be NR 1 ′, O, or S, and when m=2, X 1 can only be CH; with the proviso that the compound of formula (I) is not N-[4-(trifluoromethoxy)phenyl]-4-quinazolineamine.