Patent ID: 8350052

Claim:
A process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole represented by the following formula (I): in which R 1 and R 2 , which may be the same or different, are hydrogen or an alkyl group having 1 to 6 carbon atoms, R 3 , R 4 and R 8 , which may be the same or different, may be hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, R 5 may be hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, a halogen atom, or together with one of R 6 and R 7 may form a ring having 5 or 6 carbon atoms, R 6 and R 7 , which may be the same or different, may be hydrogen, an alkyl group having 1 to 5 carbon atoms, or one of R 6 and R 7 together with R 5 may form a ring having 5 or 6 carbon atoms, R 10 and R 11 , which may be the same or different, are hydrogen or an alkyl group having 1 to 5 carbon atoms, and R 12 is hydrogen or an alkyl group having 1 to 4 carbon atoms, in which a) 1-benzyl-3-hydroxymethyl-1H-indazole represented by the following formula (II): is caused to react with a hydrohalogen acid of formula HX″, where X″ is a halogen atom selected from the group consisting of chlorine, bromine and iodine, to form 1-benzyl-3-halogenomethyl-1H-indazole represented by the following formula (V): b) 1-benzyl-3-halogenomethyl-1H-indazole represented by the abovementioned formula (V) is caused to react in the presence of a strong base with a compound represented by the following formula (VI): to form the 1-benzyl-3-hydroxymethyl-1H-indazole represented by the abovementioned formula (I).