Patent ID: 7803522

Claim:
A therapeutic composition for stimulating elastogenesis or the appearance thereof comprising a therapeutically effective amount of a population of cultured dermal fibroblasts, wherein said population of cultured dermal fibroblasts is pretreated with an elastin peptide fragment, wherein said elastin peptide fragment consists of a peptide having the sequence selected from the group consisting of PGGVLPG (SEQ ID NO: 47), VGVVPG (SEQ ID NO: 48), IGLGPGGV (SEQ ID NO: 49), VGAMPG (SEQ ID NO: 51), VGLSPG (SEQ ID NO: 52), IGAMPG (SEQ ID NO: 54), IGVAPG (SEQ ID NO: 55), IGLSPG (SEQ ID NO: 56), VGAMPGAAAAAVGAMPG (SEQ ID NO: 58), VGLSPGAAAAAVGLSPG (SEQ ID NO; 59), VGVAPGAAAAAVGVAPG (SEQ ID NO: 60)JGAMPGAAAAAIGAMPG (SEQ ID NO: 61), IGLSPGAAAAAIGLSPG (SEQ ID NO: 63), IGVAPGAAAAAIGVAPG (SEQ ID NO: 62), and GXXPG (SEQ ID NO: 2).