Patent ID: 7642251

Claim:
A compound of formula I where: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is pyridinyl, pyrazinyl, pyrimidinyl, or pyridazinyl, and is substituted with 0-1 substituents selected from the group consisting of (R 5 ) 2 N, R 12 , COR 13 , and SO 2 R 14 ; or R 2 is phenyl and is substituted with 0-2 substituents selected from halo, alkyl, alkoxy, and haloalkoxy and is substituted with 0-1 substituents selected from the group consisting of (R 5 ) 2 N, ((R 5 ) 2 N)alkyl(R 5 )N, (R 12 )alkyl(R 5 )N, alkylCON(R 5 ), cycloalkylCON(R 5 ), (methyl)oxadiazolyl, ((R 5 ) 2 N)alkoxy, (R 12 )alkoxy, R 12 , ((R 5 ) 2 N)alkyl, (R 12 )alkyl, COR 13 , (alkylSO 2 )alkyl, and SO 2 R 14 ; or R 2 is indolyl, indazolyl, benzimidazolyl, benzotriazolyl, pyrrolopyridinyl, benzoxazolyl, benzothiazolyl, and is substituted with 0-2 substituents selected from halo, alkyl, haloalkyl, nitro, cyano, alkoxy, and haloalkoxy; or R 2 is benzodioxolyl or dihydrobenzodioxinyl, and is substituted with 0-2 substituents selected from halo and alkyl; R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , (R 9 )(R 10 )NSO 2 , or (R 11 )SO 2 ; R 7 is hydrogen or alkyl; R 8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO 2 , cycloalkylSO 2 , haloalkylSO 2 , aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl; R 9 is hydrogen or alkyl; R 10 is hydrogen or alkyl; R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl; R 12 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from oxo and alkyl; R 13 is hydroxy, alkoxy, amino, alkylamino, dialkylamino, azetidinyl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperazinyl, N-alkylpiperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homomorpholinyl, R 14 is hydroxy, alkoxy, (R 5 ) 2 N, ((R 5 ) 2 N)alkyl, ((R 5 ) 2 N)alkyl(R 5 )N, (R 12 )alkyl, (R 12 )alkyl(R 5 )N, azetidinyl, pyrrolidinyl, piperidinyl, hydroxypiperidinyl, piperazinyl, N-alkylpiperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homomorpholinyl, X is methylene, a bond, or absent; or a pharmaceutically acceptable salt thereof.