Patent ID: 8586617

Claim:
A compound of formula I wherein: R 1 is selected from the group consisting of: hydrogen; lower alkyl; —(CR 2 ) n —OH; —(CH 2 ) n -aryl, optionally substituted by halogen, lower alkoxy, or lower alkyl substituted by halogen; —(CH 2 ) n -heteroaryl, optionally substituted by halogen, lower alkoxy, or lower alkyl substituted by halogen; —(CR 2 ) n -cycloalkyl, optionally substituted by hydroxyl; —(CH 2 ) n -heterocyclyl; —(CH 2 ) n —NH—S(O) 2 CH 3 ; and —(CR 2 ) n O-lower alkyl substituted by halogen; each R is independently selected from the group consisting of hydrogen and lower alkyl; R 2 is selected from the group consisting of: aryl, substituted by one or more substituents, selected from the group consisting of: cycloalkyl; lower alkoxy substituted by halogen; —(CH 2 ) n —S(O) 2 —NH-lower alkyl; —(CH 2 ) n —O-lower alkyl; —NHC(O)-lower alkyl; —O-tetrahydro-naphthalenyl; —(CH 2 ) n -aryl, optionally substituted by-halogen, by aryloxy optionally substituted by halogen, by lower alkoxy, or by lower alkyl substituted by halogen; —CH═CH-aryl optionally substituted by halogen; —(CH 2 ) n —O-aryl optionally substituted by halogen, lower alkoxy, or lower alkyl substituted by halogen; —O—(CH 2 ) n -aryl, optionally substituted by halogen; —(CH 2 ) n -heteroaryl,-optionally-substituted by ═O; —(CH 2 ) n —O-heteroaryl; —(CH 2 ) n -heterocyclyl,-optionally substituted by ═O; —(C 2 ) n —O-heterocyclyl, optionally substituted by lower alkyl; —S-aryl; —CH(OH)-aryl; —C(CH 3 ) 2 -aryl; —NR-aryl; and 2-oxo-2H-pyridin-1-yl; R 3 is selected from the group consisting of: hydrogen and lower alkyl; R 4 is selected from the group consisting of: hydrogen and lower alkyl; and n is 1, 2, 3 or 4; or a pharmaceutically active salt thereof.