Patent ID: 8071622

Claim:
A compound of formula (Ia) R 1 is hydrogen, C 1-6 -alkyl, optionally substituted by CN or OH, or â€”(C 1-6 -alkylene)-C(O)â€”NR a R b ; R 2 is hydrogen, C 1-6 -alkyl, C 1-6 -alkoxy, â€”(C 1-6 -alkylene)-NR c R d , â€”(C 1-6 -alkylene)-C(O)R f , benzyl, optionally subsitituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano, or phenyl, optionally subsitituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano; R 3 is hydrogen, halo, or C 1-6 -alkyl; R 4 is hydrogen, halo, C 1-6 -alkyl, halo-C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, or â€”Oâ€”C 2-10 -alkenyl; R 5 is hydrogen, halo, C 1-6 -alkyl, or C 1-6 -alkoxy; R 6 is hydrogen, C 1-6 -alkyl, optionally substituted by CN or OH, â€”(C 1-6 -alkylene)-NR g R h , â€”(C 1-6 -alkylene)-C(O)â€”NR i R j , â€”O-benzyl, optionally subsitituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano, nitro, halo, cyano, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, halo-C 1-6 -alkyl, â€”(C 1-6 -alkylene)-C(O)R f , phenyl, optionally subsitituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano, â€”(C 1-3 -alkylene)-R m , wherein R m is phenyl, a 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl or 3 to 6-membered cycloalkyl, each optionally substituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano; R 7 is hydrogen or C 1-6 -alkyl; R 8 , R 9 , R 10 , and R 11 are each independently hydrogen, halo, C 1-6 -alkyl, halo-C 1-6 -alkyl, C 1-6 -alkoxy or halo-C 1-6 -alkoxy; R a , R b , R i and R j are each independently hydrogen, C 1-6 -alkyl, â€”(C 1-6 -alkylene)-NR k R l , wherein R k and R l are each independently hydrogen or C 1-6 -alkyl, or R a and R b , or R i and R j together with the nitrogen to which they are bound form a five or six membered heterocycle comprising one or two heteroatoms selected from the group of nitrogen, oxygen and sulfur; R c , R d R g and R h are each independently hydrogen, C 1-6 -alkyl, â€”C(O)R e , or â€”S(O) 2 R e wherein R e is selected from the group of hydrogen, C 1-6 -alkyl, and phenyl, optionally substituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano; or R c and R d , or R g and R h together with the nitrogen to which they are bound form a five or six membered heterocycle comprising one or two heteroatoms selected from the group of nitrogen, oxygen and sulfur; or R c and R d , or R g and R h together with the nitrogen to which they are bound form isoindole-1,3-dione; R f is selected from hydrogen, C 1-6 -alkyl, C 1-6 -alkoxy; and phenyl, optionally substituted by one or more halo, halo-C 1-6 -alkyl, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkoxy, nitro, or cyano; or a pharmaceutically acceptable salt thereof.