Patent ID: 8785452

Claim:
A compound having the general formula VIIIa: wherein X 5 is selected from the group consisting of CH 2 and C═O; Z 1 is selected from the group consisting of alkoxy, alkylamino, alkylether, alkylthio, alkynyl, amido, amino, aryl, arylalkoxy, arylamino, arylthio, carboxy, cyano, cycloalkyl, ester, halo, haloalkoxy, haloalkyl, heteroaryl, heteroarylamino, heterocycloalkyl, and hydroxyl, any of which is optionally substituted; Z 2 is selected from the group consisting of alkoxy, alkyl, alkylamino, alkylether, alkylthio, alkynyl, amido, amino, aryl, arylalkoxy, arylamino, arylthio, carboxy, cyano, cycloalkyl, ester, halo, haloalkoxy, haloalkyl, heteroaryl, heteroarylamino, heterocycloalkyl, hydroxyl, and hydrogen, any of which is optionally substituted; R 27 and R 28 are each independently selected from the group consisting of alkoxy, alkyl, alkyl amino, alkeny, alkylether, alkylthio, alkynyl, amido, amino, aryl, arylether, arylalkoxy, arylamino, arylthio, carboxy, cyano, cycloalkyl, ester, halo, haloalkoxy, haloalkyl, heteroaryl, heteroarylamino, heterocycloalkyl, hydroxyl, hydrogen, nitro, thiol, sulfonate, sulfonyl and sulfonylamino, any of which is optionally substituted; and R 29 and R 30 are each independently selected from the group consisting of alkoxy, alkyl, alkylamino, alkenyl, alkylether, alkylthio, alkynyl, amido, amino, aryl, arylether, arylalkoxy, arylamino, arylthio, carboxy, cyano, cycloalkyl, ester, halo, haloalkoxy, haloalkyl, heteroaryl, heteroarylamino, heterocycloalkyl, hydroxyl, hydrogen, nitro, thiol, sulfonate, sulfonyl and sulfonylamino, or two groups are connected to each other to make five or six membered cyclic, heterocyclic, aryl, and heteroaryl rings, any of which is optionally substituted, wherein Z 1 and Z 2 may be connected to each other to make five or six membered cyclic, heterocyclic and heteroaryl rings, any of which is optionally substituted.