Patent ID: 7897154

Claim:
A method to ameliorate the symptoms of a condition that is diabetes, pain or carpal tunnel syndrome in a mammalian subject which method comprises applying, topically to the skin of said subject, a culture filtrate wherein, said filtrate is from a Basidiomycetes fungal culture that has been cultured for at least 1 year in a medium containing at least 10% available carbohydrate and a BRIX value of 5-16, that contains 0.01-0.7% wt/vol potassium ion and sufficient carotenoid compounds to impart a yellow, orange or red color, and wherein said culture is grown in the presence of long wavelength or white light, and in the substantial absence of agitation, and wherein said filtrate is the liquid portion of said culture and from which proteins have been denatured and removed, and wherein said filtrate is concentrated to at least a BRIX value of 20, or a pharmaceutical composition thereof.