Patent ID: 8003597

Claim:
A method of preparing a pharmaceutical composition comprising a G protein-coupled receptor 119 (GPR119) agonist having the effect of a Glucagon-like peptide-1 (GLP-1) secretagogue useful for treating a condition ameliorated by increasing a blood GLP-1 level, the method comprising: (a) contacting the GPR119 agonist in vitro with a mammalian enteroendocrine cell; (b) determining whether the GPR119 agonist stimulates GLP-1 secretion from the mammalian enteroendocrine cell, wherein the ability of the GPR119 agonist to stimulate GLP-1 secretion from the mammalian enteroendocrine cell is indicative of the agonist being the GLP-1 secretagogue useful for treating a condition ameliorated by increasing a blood GLP-1 level; and (c) admixing the GPR119 agonist with a pharmaceutically acceptable carrier.