Patent ID: 8535721

Claim:
Pharmaceutical microspheres, containing, as active principle, a mixture of valproic acid and of one of its pharmaceutically acceptable salts in combination with a matrix vehicle selected from the group consisting of saturated or unsaturated fatty acid glycerides, hydrogenated oils, saturated polyglyclolysed glycerides, and waxes, and their mixtures, the amount of active principle representing from 30% to 35% by weight of the total weight of the microspheres, thereby the dissolution of the active principle in the matrix vehicle is facilitated, wherein the active principle contains a mixture of 15% to 60% by weight of valproic acid and of 40% to 85% by weight of pharmaceutically acceptable salt of this acid, said microspheres being of a regular size and of a regular spherical shape having a monodisperse particle size distribution with a diameter between 250 μm and 500 μm such that the amount of said microspheres received by a patient is constant.