Patent ID: 8877928

Claim:
A PEGylated cyclopamine analog comprising a compound represented by the following formula I: or a single enantiomer thereof, a mixture of enantiomers, or a mixture of diastereomers, or a pharmaceutically acceptable salt thereof, wherein: R is straight or branched polyethylene glycol having a molecular weight of 200 to 200,000 Dalton, L is a linking group represented by the following formula II: wherein R 2 is selected from the group consisting of —NR e C(O)R h and —NR e C(O)OR f , wherein R e is each independently selected from the group consisting of hydrogen, C 1-6 alkyl and C 2-6 alkenyl, R f and R h are each independently selected from the group consisting of C 1-6 alkylene and C 2-6 alkenylene; Y is selected from the group consisting of O, N, S—S, methylene, and ethylidene; m is an integer of 0-6; X is a linking group between cyclopamine and L, which is selected from the group consisting of —C(O), —OC(O), —NHC(O), —OS(O) 2 and —OS(O).