Patent ID: 8633201

Claim:
A compound of the formula (1) wherein X is O; R 1 is C 3-6 alkyl optionally substituted with one or more halogen atoms, C 3-10 cycloalkyl, or 3 to 10 membered heterocycloalkyl comprising a heteroatom selected from N and O and, optionally substituted with one or more R 9 ; R 2 and R 3 are the same or different and are independently selected from hydrogen and C 1-6 alkyl; R 4 is hydrogen, C 1-4 alkyl, urea, thiourea or acetyl optionally substituted with one or more R 9 ; R 5 , R 7 and R 8 are hydrogen; R 6 is selected from, halogen, —C(O)N(R 11 R 11a ) and —COOR 11 ; R 9 is independently halogen; CN; COOR 11 ; OR 11 ; C(O)N(R 11 R 11a ); S(O) 2 N(R 11 R 11a ); S(O)N(R 1 1 R 11a ); S(O) 2 R 11 ; N(R 11 )S(O) 2 N(R 11a R 11b ); SR 11 ; N(R 11 R 11a ); OC(O)R 11 ; N(R 11 )C(O)R 11a ; N(R 11 )S(O)R 11a ; N(R 11 )S(O)R 11a ; N(R 11 )C(O)N(R 11a R 11b ); N(R 11 )C(O)OR 11a ; OC(O)N(R 11 R 11a ); oxo (═O); C(O)R 11 ; C 11b alkyl; phenyl; C 3-7 cycloalkyl; or 5 or 6 membered saturated, unsaturated or aromatic heterocyclyl comprising at least one heteroatom selected from N, S and O; wherein C 1-6 alkyl, phenyl, C 3-7 cycloalkyl, and heterocyclyl are optionally substituted with one or more R 10 ; R 10 is independently halogen; CN; OR 11 ; S(O) 2 N(R 11 R 11a ); S(O)N(R 11 R 11a ); S(O) 2 R 11 ; N(R 11 )S(O) 2 N(R 11a R 11b ); SR 11 ; N(R 11 R 11a ); OC(O)R 11 ; N(R 11 )C(O)R 11a ; N(R 11 )S(O) 2 R 11a ; N(R 11 )S(O)R 11a ; N(R 11 )C(O)N(R 11a R 11b ); N(R 11 )C(O)OR 11a ; OC(O)N(R 11 R 11a ); oxo (═O); C(O)R 11 ; C 1-6 alkyl; phenyl; C 3-7 cycloalkyl; or heterocyclyl; R 11 , R 11a , R 11b are independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 alkyl C 3-10 cycloalkyl, C 3-10 cycloalkyl, C 1-6 alkyl 3 to 10 membered heterocycloalkyl comprising at least one heteroatom selected from N, S and O, 3 to 10 membered heterocycloalkyl comprising at least one heteroatom selected from N, S and O, C 6-10 aryl, 5 to 10 membered heteroaryl comprising at least one heteroatom selected from N, S and O; or a pharmaceutically acceptable salt thereof.