Patent ID: 8785178

Claim:
A perifusion device, comprising: a plurality of sample containers; the sample containers having a liquid inlet and a liquid outlet, the containers receiving liquid through the inlet and discharging liquid through the outlet; a plurality of liquid sources for supplying a plurality of liquids to said sample containers; a plurality of manifolds disposed between the liquid sources and the sample containers, each manifold having a plurality of manifold inlets and at least one manifold outlet, each liquid source being in fluid connection to at least one manifold inlet, each manifold outlet being in fluid communication with a plurality of manifold inlets, each manifold outlet being in fluid connection with a liquid inlet of a sample container; a plurality of valves, said valves controlling liquid flow from the liquid sources through the manifold inlets; at least one pump for pumping liquid from the manifold outlets to respective sample containers; a receptacle housing having a plurality of receptacles for receiving fluid from the liquid outlets of the sample containers, said plurality of receptacles being positioned in said receptacle housing such that different receptacles receive samples from different liquid outlets of each of said sample containers; a drive connected to the receptacle housing for moving said receptacle housing such that samples from the outlet are collected in said plurality of receptacles; and, a programmable controller that is programmed to operate the driver to move the receptacles at predetermined times, to operate the valves, and to record the position of the valves and the receptacles as a function of time so as to correlate the liquids that are supplied to each sample container from the plurality of liquid sources with the liquid samples that are received by the receptacles from the sample containers.