Patent ID: 7504422

Claim:
A method of treating retinopathy, comprising administering to an eye of a subject in need thereof an effective amount of a compound of the formula: wherein X is —CH 2 —, —C 2 H 4 —, —C 3 H 6 —, —CH 2 —CH═CH—, —CH═CH—CH 2 —, —C(O)—, —SO 2 —, or deleted; Y is aryl, heteroaryl, C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl, C 3 -C 8 heterocycloalkyl, C 5 -C 8 heterocycloalkenyl, or deleted; each of Z 1 and Z 2 , independently, is —CH 2 —, —C 2 H 4 —, —C 3 H 6 —, —CH═CH—, —CH═N—, —CH═N—NR—, —S—, —O—, —NR—, —C(O)—, or —SO 2 —; R 1 is H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl, C 3 -C 8 heterocycloalkyl; C 5 -C 8 heterocycloalkenyl, aryl, or heteroaryl; R 2 is -A 1 -B 1 -D 1 -E 1 ; R 3 is -A 2 -B 2 -D 2 -E 2 , deleted, or, together with R 4 , is C 4 -C 20 cycloalkyl, C 4 -C 20 cycloalkenyl, C 4 -C 20 heterocycloalkyl, or C 4 -C 20 heterocycloalkenyl; provided that if R 3 is deleted, -Z 2 -N— is —CH═N—; and R 4 is -A 3 -B 3 -D 3 -E 3 or, together with R 3 , is C 4 -C 20 cycloalkyl, C 4 -C 20 cycloalkenyl, C 4 -C 20 heterocycloalkyl, or C 4 -C 20 heterocycloalkenyl; in which each of A 1 , A 2 , and A 3 , independently, is —CH 2 —, —C 2 H 4 —, —C 3 H 6 —, —C 4 H 8 —, —C 5 H 10 —, —CH 2 C(O)—, —C(O)CH 2 —, —CH 2 SO 2 —, —SO 2 CH 2 —, —CH 2 —CH═CH—, —CH═CH—CH 2 —, —CH(CH 2 OR)—, —CH(CH 2 CH 2 OR)—, —CH(COOR)—, —CH(CH 2 COOR)—, —CH(C(O)NR 2 )—, or deleted; each of B 1 , B 2 , and B 3 , independently, is —NR—, —CH 2 —, or deleted; each of D 1 , D 2 , and D 3 , independently, is —CH 2 —, —C 2 H 4 —, —C 3 H 6 —, —CH 2 —CH═CH—, —CH═CH—CH 2 —, —C(O)—, —SO 2 —, —C(O)—NR—, —C(S)—NR—, —NR—C(O)—, —NR—C(S)—, —CH(OR)—, —CH(CH 2 OR)—, —CH(CH 2 CH 2 OR)—, —CH(COOR)—, 1,1-cyclopropylene, or deleted; and each of E 1 , E 2 , and E 3 , independently, is H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl, C 3 -C 8 heterocycloalkyl, C 5 -C 8 heterocycloalkenyl, aryl, or heteroaryl; each R, independently, being H or C 1 -C 10 alkyl.