Patent ID: 8318765

Claim:
A method of treating a mammal having a medical condition ameliorated by treatment with a mu opioid receptor antagonist, wherein the medical condition is opioid-induced bowel dysfunction or post-operative ileus, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I): wherein R 1 is —OR a or —C(O)NR b R c ; R 2 , R 3 , and R 4 are each independently C 1-3 alkyl; R 5 is selected from C 1-6 alkyl, phenyl, cyclohexyl, —(CH 2 ) 1-3 -cyclohexyl, and —(CH 2 ) 1-3 phenyl; R a , R b , and R c are each independently hydrogen or C 1-3 alkyl; and R 6 is hydrogen or C 1-3 alkyl; and wherein the substituents at the chiral centers marked by asterisks are in the trans configuration; or a pharmaceutically-acceptable salt thereof.