Patent ID: 8812245

Claim:
A method for non-invasive assessment of coronary artery stenosis, comprising: extracting, using at least one processor, patient-specific anatomical measurements of the coronary arteries from medical image data of a patient acquired during a rest state; calculating, using the at least one processor, patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest; calculating, using the at least one processor, patient-specific hyperemic boundary conditions of the model of coronary circulation using the rest boundary conditions and using a model for simulated hyperemia; simulating, using the at least one processor, hyperemic blood flow and pressure across at least one stenosis region of at least one coronary artery using the model of coronary circulation and the patient-specific hyperemic boundary conditions; and calculating, using the at least one processor, fractional flow reserve (FFR) of the at least one stenosis region based on the simulated hyperemic blood flow and pressure.