Patent ID: 8158441

Claim:
A method for detecting at least one aggregate-forming circulating protein form associated with noninfectious neurodegenerative diseases in a biological sample of human origin that may contain said aggregate-forming circulating protein forms, said aggregate-forming circulating protein forms containing: amino acids whose side chains have either an acid function or a hydrogen-bond-acceptor function being present overall at least four times in a peptide sequence of length less than or equal to twenty amino acids, and a minimum of three basic amino acids in a peptide sequence of a length of less than or equal to fifteen amino acids; the method comprising: aggregating the circulating forms of the noninfectious proteins involved in pathological aggregation processes of the central nervous system by contacting the biological sample with a non-protein agent I selected from the group consisting of rifampicin, isoniazide ethambutol, triethylenetetraamine (TET), bis-3-aminopropylamine, spermine tetrahydrochloride, dihydrostreptomycin sesquisulfate, and streptomycin; and capturing natural aggregates of aggregate-forming circulating protein forms or the aggregates induced by said agent I by adding to the biological sample a non protein agent II selected from metacyclophane or a glycoaminoglycane; and revealing the presence of the aggregate-forming circulating protein forms.