Patent ID: 7273863

Claim:
A compound of formula (I) wherein X is O; R 1 is C 6-14 aryl substituted with one or more substituents selected from the group consisting of halogen, —CF 3 , C 1-8 alkyl, —CN, —SR 6 , —S(O) 2 R 6 ; or heterocycle, optionally substituted with one or more substituents selected from the group consisting of C 1-8 alkyl, —CN, and C 6-14 arylC 1-8 alkyl; R 6 is C 1-8 alkyl, optionally substituted with halogen; R 7 is C 1-8 alkyl optionally substituted with hydroxy; —NH 2 ; or heterocycle; R 2 is hydrogen; R 3 is hydrogen or C 1-8 alkyl; R 4 is heterocycle, optionally substituted with one or more substituents selected from the group consisting of oxo, halogen, C 1-8 alkyl, —OR 11 and —SR 10 N(R 10 ) 2 , S(O) 2 NR 8 R 9 ; or C 6-14 aryl substituted with one or more substituents selected from the group consisting of hydroxy, halogen, —CF 3 , C 1-8 alkyl, hydroxyC 1-8 alkyl, —CN, —NO 2 , —C(O)NH 2 , —S(O)R 7 , —S(O) 2 R 7 , —S(O)NR 8 R 9 , —OR 11 , —C(O)NR 11 , —C(O)OR 11 , —NR 11 , —NC(O)R 11 , and heterocycle which may be optionally substituted with one or more substituents selected from the group consisting of oxo, C 1-8 alkyl and heterocycleC 1-8 alkyl; R 8 and R 9 are the same or different and are selected from the group consisting of hydrogen, C 1-8 alkyl, C 1-8 alkylheterocycle, heterocycle, and C 3-6 cycloalkyl; R 10 is C 1-8 alkyl; R 11 is C 1-8 alkyl, optionally substituted with —SO 2 NR 8 R 9 ; and R 5 is halogen or —NO 2 ; or a pharmaceutically acceptable salt thereof.