Patent ID: 7803795

Claim:
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n is 0, 1, 2 or 3; Q is —C(═O)—; each X is independently —N< or —CH<; and when X is —CH< then Y is —N<, or —NH— and when X is —N< then Y is —CH═ or —CH2-; L 1 is a direct bond or a bivalent radical selected from —C 1-6 alkanediyl-NH—, —NH— or —NH—C 1-6 alkanediyl-NH—; L 2 is a direct bond or a bivalent radical selected from —C 1-6 alkanediyl-, —C 2-6 alkenediyl-, carbonyl or —C 1-6 alkanediyl-substituted with one substituent selected from hydroxy or aryl; R 1 is hydrogen, nitro, halo or amino; R 2 is hydrogen, C 1-6 alkyl or arylC 1-6 alkyl; the central moiety may also be bridged with an ethylene bridge; Z is hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, aryloxy, amino, cyano, arylC 1-6 alkylamino or benzthiazolyl(C 1-6 alkyl)amino or a ring system selected from wherein R 4 and R 5 are each independently selected from hydrogen, halo, C 1-6 alkyl, C 1-6 alkyloxy or trihalomethyl; aryl is phenyl, or phenyl substituted with one or two substituents each independently selected from halo, C 1-6 alkyl or C 1-6 alkyloxy; with the proviso that when Q is C(═O)— and X is —N< and Y is —CH< or —CH 2 and L 1 is a direct bond and L 2 is a direct bond, or the bivalent radical —C 1-6 alkanediyl- or —C 1-6 alkanediyl-substituted with hydroxy and R 1 is hydrogen and R 2 is hydrogen or C 1-6 alkyl then Z is other than hydrogen, hydroxy or C 1-6 alkyl.