Patent ID: 7253165

Claim:
A compound of Formula I: a pharmaceutically acceptable salt or stereoisomer thereof, wherein T, T′ and T″ are respectively C, O and N producing benzisoxazolyl, C, S and C producing benzthienyl, or N, O and N producing pyridoisoxazolyl; X is hydrogen or halo; A is —CH 2 CH 2 — or —CH 2 C(R 1 )(R 2 )CH 2 —, wherein R 1 is H, OH or C 1-6 alkoxy; and R 2 is H or C 1-6 alkyl; R 3 is (CH 2 ) n Q, CH 2 CH(OH)Q, CH(CH 3 )Q, 1,2,3,4-tetrahydronaphthyl, indanyl optionally substituted with hydroxy, or adamantyl, wherein Q is thienyl, phenyl, furanyl, naphthyl, pyridyl, indolyl, indazolyl, cyclohexyl, 1,2-methylenedioxyphenyl, cyclohexenyl, 1H-pyrazolo[4.3-c]pyridyl, and Q is optionally substituted with one or two moieties independently selected from halo, C 1-6 alkyl, C 1-6 alkoxy, hydroxy, S(O) 2 NH 2 , trifluoromethyl, or cyano, and n is 0,1 or 2; R 4 is H or C 1-6 alkyl; or R 3 and R 4 , together with the nitrogen atom to which R 3 and R 4 are attached, form 4,5,6,7-tetrahydrothieno [3,2,c] pyridinyl,1,4-dioxa-8-azo-spiro[4.5]decanyl, piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, azepanyl, azocanyl, 1,2,3,4-tetrahydroisoquinolinyl, 1,2,3,4-tetrahydro-1H-β-yl, or 8-aza-bicyclo[3.2.1.]octanyl, each of which may be mono- or independently di-substituted with halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxymethyl, C(O)phenyl, OH, phenyl, CN, O-phenyl or (CH 2 ) m Z, Z is benzisoxazolyl, indazolyl, benzisothiazolyl, benzthienyl, pyrimidinyl, pyridyl, 1,2-methylenedioxyphenyl, or phenyl, and Z, CH(OH)phenyl, phenyl or O-phenyl are optionally substituted with one or two moieties independently selected from halo, C 1-6 alkyl, C 1-6 alkoxy, hydroxy, trifluoromethyl, S(O) 2 NH 2 or cyano, and m is 0 or 1.