Patent ID: 8680151

Claim:
A method of making a linear symmetrical or asymmetrical trisulfide compound represented by the structure: wherein R 1 and R 2 are independently a branched or straight chain C 1-10 alkyl; a branched or straight chain C 1-10 alkyl substituted with —ONO 2 ; or, a branched or straight chain C 1-10 alkyl substituted with —OH; wherein R 3 and R 4 are independently a branched or straight chain C 1-10 alkanediyl; wherein R 5 and R 6 are independently OH, an amino acid moiety, or, a straight or branched chain C 1-10 amine substituted with —ONO 2 ; wherein X and Y are independently C═O or SO 2 ; and, wherein Z is selected from H, CH 3 , and CH 2 CH 3 ; the method comprising: reacting a compound represented by the following structure wherein R 1 , X, R 3 and R 5 are as defined above, with an equal molar amount of 2,2′-thiodiisoindoline-1,3-dione in acetonitrile and water to produce a ((1,3-dioxoisoindolin-2-yl)disulfanyl)-containing intermediate; isolating the intermediate; and reacting the intermediate with a compound represented by the following structure wherein R 2 , X, R 4 and R 6 are as defined above, in an aqueous alcohol solution, thereby forming the trisulfide compound.