Patent ID: 8420675

Claim:
A compound of formula I: or a pharmaceutically acceptable salt or ester thereof; wherein: X is a direct bond, oxygen, or —S(O) 2 —; and X is bonded to the ring containing Q by substitution of a hydrogen atom of a ring carbon atom; Q is nitrogen and W is carbon or nitrogen with the proviso that when W is nitrogen, the nitrogen is unsubstituted; R 1 is hydrogen or methyl; R 2 and R 3 are bonded to the ring containing Q by substitution of a hydrogen atom of a ring carbon atom; and R 2 and R 3 , independently of each other, are selected from the group consisting of: (1) hydrogen; (2) halogen; (3) lower alkyl optionally substituted by halogen; and (4) lower cycloalkyl optionally substituted by lower alkyl; R 4 and R 5 are bonded to the ring containing W by substitution of a hydrogen atom of a ring carbon atom; and R 4 and R 5 , independently of each other, are selected from the group consisting of: (1) hydrogen; (2) hydroxyl; (3) halogen; (4) nitro; (5) cyano; (6) lower alkyl optionally substituted by halogen; (7) lower alkoxy optionally substituted by halogen; (8) lower cycloalkoxy; (9) lower heterocycloalkyloxy; (10) lower alkanoyl; (11) carbamoyl, lower alkylaminocarbonyl, or lower dialkylaminocarbonyl; (12) lower alkylcarbonylamino; (13) lower alkylsulfanyl or lower cycloalkylsulfanyl (14) lower alkylsulfinyl or lower cycloalkylsulfinyl; (15) lower alkylsulfonyl or lower cycloalkylsulfonyl; and (16) trimethylsilyl; and n is 1 or 2.