Patent ID: 8716234

Claim:
A method of inhibiting or destroying a lymphoma cancer cell comprising administering a cytotoxin to an animal having lymphoma, wherein said cytotoxin comprises a targeting moiety that binds to the lymphoma cancer cell and is linked to a modified bouganin protein, wherein said modified bouganin protein comprises: YNTVSFNLGEAYEYPTFIQDLRNELAKGTPVCQLPVTLQTIADDKRFVLVDITT TSKKTVKVAIDVTDVYVVGYQDKWDGKDRAVFLDKVPTVATSKLFPGVTNRVTLTFD GSYQKLVNAAKX 1 DRKX 2 LX 3 LGVX 4 KLEFSIEAIHGKTINGQEX 5 AKFFLIVIQMVSEAAR FKYIETEVVDRGLYGSFKPNFKVLNLENNWGDISDAIHKSSPQCTTINPALQLISPSNDPW VVNKVSQISPDMGILKFKSSK (SEQ ID NO: 11) wherein at least one of X 1 through X 5 is substituted with a different amino acid compared to the non-modified bouganin protein of SEQ ID NO: 1, wherein, when substituted, X 1 is T or A or Q, wherein, when substituted, X 2 is G or A, wherein, when substituted, X 3 is Q or G, wherein, when substituted, X 4 is N or D or T or A or R or Q or E or G or H or K or S, and wherein, when substituted, X 5 is Q or A and wherein, said modified bouganin protein has ribosome inactivating activity.