Patent ID: 8859777

Claim:
A compound of formula: wherein R 1 is from one to three substituents chosen independently in each occurrence from hydrogen, halogen, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )acyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, heteroaryl, benzenesulfonyl, toluenesulfonyl, hydroxy, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, (C 1 -C 6 )oxaalkyl, carboxy, carboxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonylamino, carboxamido, (C 1 -C 6 )alkylaminocarbonyl, (C 1 -C 6 )alkylaminocarbonyloxy, (C 1 -C 6 )alkylaminocarbonylamino, cyano, acetoxy, nitro, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino(C 1 -C 6 )alkoxy, mercapto, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfonylamino, benzenesulfonylamino, toluenesulfonylamino, (C 1 -C 6 )alkylaminosulfonyl, di(C 1 -C 6 )alkylaminosulfonyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )acylamino, aryl, benzyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, phenoxy, benzyloxy, heteroaryloxy, hydroxyimino, (C 1 -C 6 )alkoxyimino, oxaalkyl, amidino, and guanidino; R 2 and R 3 are independently chosen from hydrogen and (C 1 -C 6 )alkyl; A is a (C 1 -C 8 )alkylene chain wherein one to three methylenes may be optionally replaced by oxygen or —CR 4 R 5 —; R 4 and R 5 are independently chosen from hydrogen, (C 1 -C 10 )alkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )acyl, hydroxy(C 1 -C 6 )alkyl, hydroxy, (C 1 -C 6 )alkoxy, hydroxy(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, (C 1 -C 6 )oxaalkyl, carboxy, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonylamino, carboxamido, (C 1 -C 6 )alkylaminocarbonyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, aryl, benzyl, heterocyclyl, heterocyclyl(C 1 -C 6 )alkyl, phenoxy, benzyloxy and heteroaryloxy; and U is chosen from optionally substituted (C 3 -C 8 )carbocycle, thiophene and furanyl.