Patent ID: 7956054

Claim:
A compound of formula I: where: Z is a pyrazole selected from: Ar is selected from: R 1 is selected from —SO 2 NHC(O)R 1a , tetrazolyl, —C(O)OR 1b , where R 1a is —C 1-6 alkyl, —C 0-6 alkylene-OR, —C 3-7 cycloalkyl, —C 0-5 alkylene-NR 1b R 1b , pyridyl, isoxazolyl, methylisoxazolyl, pyrrolidinyl, morpholinyl, and phenyl optionally substituted with halo; where each R 1b is independently selected from H and —C 1-6 alkyl; a is 0, 1, or 2; R 2 is F; R 3 is selected from —C 2-5 alkyl and —O—C 1-5 alkyl; R 4 is selected from —CH 2 —SR 4a , —CH 2 —N(OH)C(O)H, —CH(R 4b )C(O)NH(OR 4d ), and —CH(R 4b )C(O)OR 4c ; where R 4a is H or —C(O)—C 1-6 alkyl; R 4b is H or —OH; R 4c is H, —C 1-6 alkyl, —C 0-6 alkylenemorpholine, —CH 2 OC(O)O—C 1-6 alkyl, —CH(CH 3 )OC(O)O—C 1-6 alkyl, —CH(CH 3 )OC(O)O—C 3-7 cycloalkyl, or: R 4d is H or —C(O)—R 4e ; and R 4e is —C 1-6 alkyl, —C 1-6 alkyl-NH 2 or aryl; and R 5 is selected from —C 1-6 alkyl, —CH 2 -furanyl, —CH 2 -thiophenyl, benzyl, and benzyl substituted with one or more halo, —CH 3 , or —CF 3 groups; where each ring in Ar is optionally substituted with 1 to 3 substituents independently selected from —OH, —C 1-6 alkyl, —C 2-4 alkenyl, —C 2-4 alkynyl, —CN, halo, —O—C 1-6 alkyl, —S—C 1-6 alkyl, —S(O)—C 1-6 alkyl, —S(O) 2 —C 1-4 alkyl, -phenyl, —NO 2 , —NH 2 , —NH—C 1-6 alkyl and —N(C 1-6 alkyl) 2 , wherein each alkyl, alkenyl and alkynyl is optionally substituted with 1 to 5 fluoro atoms; or a pharmaceutically acceptable salt thereof.