Patent ID: 8404663

Claim:
A compound having Formula I, its enantiomers, diastereoisomers, hydrates, or a pharmaceutically acceptable salt thereof, wherein: “ ” represents a triple bond “—C≡C—”; A is C 6-10 aryl, heterocycle, C 3-8 cycloakyl or C 3-8 cycloalkenyl; B is C 6-10 aryl, heterocycle, C 3-8 cycloakyl or C 3-8 cycloalkenyl; R 1 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 2 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 3 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 4 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 5 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 6 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; R 7 is H, halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , C 6-10 aryl, heterocycle, C 3-8 cycloakyl, C 3-8 cycloalkenyl, NR 12 R 13 or hydroxyl; R 8 is the same or independently halogen, —OC 1-8 alkyl, C 1-8 alkyl, CN, C(O)R 11 , NR 12 R 13 or hydroxyl; L 1 is O, S, NH or CH 2 ; R 9 is H or C 1-6 alkyl; L 2 is CHR 14 or O; R 10 is H, OPO 3 H 2 , carboxylic acid, hydroxyl, PO 3 H 2 , —S(O) 2 H, —P(O)MeOH or —P(O)(H)OH; R 11 is H or C 1-8 alkyl; a is 0, 1, 2 or 3; b is 0 or 1; R 12 is H or C 1-8 alkyl; R 13 is H or C 1-8 alkyl; R 14 is H, hydroxyl or C 1-8 alkyl; R 16 is O, S, C(O) or CH 2 ; and c is 0 or 1.