Patent ID: 8343567

Claim:
A method of treating the surface of a medical device with a biomolecule comprising the steps of: a) providing a polyolefin substrate forming a medical device; b) cleaning the polyolefin substrate; c) exposing the polyolefin substrate to at least one reactive gas containing plasma energy and at least one of acrylic acid and siloxane functional groups to yield at least one plasma-deposited coating on the polyolefin substrate; d) rendering at least one plasma deposited coating amino functional following plasma deposition; and e) attaching a biomolecule to the polyolefin substrate following formation of the at least one plasma-deposited coating on the polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.