Patent ID: 8398982

Claim:
A method of inhibiting the growth of a colon or rectum cancer cell that expresses a protein comprising the amino acid sequence of SEQ ID NO: 2, said method comprising contacting said cell with an antibody-drug conjugate comprising a growth-inhibitory agent or a cytotoxic agent conjugated to a first antibody that binds to said protein, wherein the binding of said antibody-drug conjugate to said protein causes an inhibition of the growth of said colon or rectum cancer cell, and wherein said first antibody is a monoclonal antibody that binds to the epitope bound by a second antibody, wherein said second antibody is produced by either of the hybridoma cell lines 12E5.1.1 (ATCC deposit number PTA-6625) or 6G10.1.1 (ATCC deposit number PTA 6623).