Patent ID: 8017782

Claim:
A 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivative according to Formula 1, wherein R 1 is (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl; R 2 is halogen; R 3 is SO 2 NR 5 R 6 or (1-4C)alkoxy, optionally substituted with one of more fluorine atoms; X is O or NR 7 ; R 4 is R 8 —(2-8C)alkyl, R 8 —(3-8C)alkenyl, R 8 —(3-8C)alkynyl or R 8 —(2-4C)alkoxy-(2-4C)alkyl; Z is CN or NO 2 ; R 5 and R 6 are independently H or (1-4C)alkyl; or R 5 together with R 6 and the N to which they are bonded form a 3-8 membered saturated ring optionally containing a further heteroatom selected from O and S; R 8 is OH, (1-4C)alkoxy, NH 2 ; NR 9 C(O)R 11 , NR 9 SO 2 R 11 or C(O)NR 9 R 10 ; R 7 and R 9 are independently H or (1-4C)alkyl; R 10 is (1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, or phenyl(1-4C)alkyl or (2-5C)heteroaryl(1-4C)alkyl, both optionally substituted on the (hetero)aromatic ring with one or more substituents selected from OH, NH 2 , halogen, NO 2 , CF 3 , CN, (1-4C)alkyl, (1-4C)alkoxy and (di)(1-4C)alkylamino; R 11 is (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy(1-4C)alkyl, (3-6C)-cycloalkyl, (1-4C)alkoxy, (di)(1-4C)alkylamino, or phenyl or (2-5C)heteroaryl, both optionally substituted on the (hetero)aromatic ring with one or more substituents selected from OH, NH 2 , halogen, NO 2 , CF 3 , CN, (1-4C)alkyl, (1-4C)alkoxy and (di)(1-4C)alkylamino; or a pharmaceutically acceptable salt thereof.