Patent ID: 7476521

Claim:
A method for an acyltransferase reaction in which an acyl group of acyl coenzyme A (acyl CoA) is transferred to an acyl group receptor to yield a desired product via a macromolecular polymerization reaction, said method comprises carrying out a combination of (i) the acyltransferase reaction by production and/or reproduction of an acyl coenzyme A from a coenzyme A in a reaction system by a chemical thioester exchange reaction with an acyl group donor which is an acyl ester of a thiol compound, and (ii) a macromolecular polymerization reaction, wherein the acyl group donor, the acyl group receptor, the coenzyme A and an acyltransferase are contained in the reaction system at the same time, an acyl group of the acyl group donor is transferred to coenzyme A by the chemical thioester exchange reaction to give an acyl coenzyme A and an acyl group of the acyl coenzyme A is transferred to the acyl group receptor, wherein the acyl group receptor is selected from the group consisting of hydroxyl alkanoate CoA (HA-CoA) and poly(hydroxyl alkanoate) (PHA-CoA), and wherein the acyltransferase is polyhydroxy alkanoate synthase.