Patent ID: 7666892

Claim:
A compound of the formula I or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof wherein X is NR1; each of Y1 and Y2 is O; Z is selected from SO 2 N(R6) and N(R7)SO 2 ; m is 1; A is selected from a direct bond and (C1-6)alkyl; R1 is H; Each R2 and R3 is independently selected from H, halogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, alkyl-heteroaryl, heteroalkyl-aryl, heteroalkyl-heteroaryl, aryl-alkyl, aryl-heteroalkyl, heteroaryl-alkyl, heteroaryl-heteroalkyl, aryl aryl, aryl-heteroaryl, heteroaryl-aryl, heteroaryl-heteroaryl, cycloalkyl-alkyl, heterocycloalkyl-alkyl; R4 is H; R6 is selected from H, alkyl, aryl, heteroaryl, alkylaryl, alkyl-heteroaryl, arylalkyl, and heteroaryl-alkyl; R5 is a bicyclic group comprising two ring structures, each ring structure independently having up to 7 ring atoms, wherein each ring structure is independently selected from cycloalkyl, aryl, heterocycloalkyl or heteroaryl, each ring structure being independently optionally substituted by one or more substituents independently selected from halogen, alkyl, alkoxy, and cyano, wherein any alkyl radical within any substituent may itself be optionally substituted with one or more halogen; and wherein each ring structure is joined to the next ring structure by a direct bond or by —O; R7 is (C1-6) alkyl; Provided that: when X is NR1, R1 is H, Y1 is O, Y2 is O, Z is SO 2 N(R6), R6 is H, R2 is H, m is 1, R3 is H, R4 is H, and A is a direct bond, then R5 is not phenyl, p-nitro-phenyl, p-ethoxyphenyl or m-methylphenyl.