Patent ID: 8062870

Claim:
A method of enantiomerically enriching an enantiomeric mixture of a compound of Formula (I), comprising: reacting the enantiomeric mixture with an enzyme selected from an esterase, a protease and a lipase to provide an enantiomerically enriched mixture having at least 90% enantiomeric excess of one enantiomer of the compound of Formula (I), wherein: R 1 is chosen from C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, substituted phenyl, and C 7-9 phenylalkyl; R 2 is chosen from C 1-4 alkyl, C 3-6 cycloalkyl, phenyl, substituted phenyl, and C 7-9 phenylalkyl; and R 3 is chosen from C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, substituted phenyl, and C 7-9 phenylalkyl.