Patent ID: 7226945

Claim:
A pharmaceutical composition comprising: a therapeutically-effective amount of a ligand that satisfies the equation: K iαA /K iβA >25, wherein K iαA is the K i value for the ligand in ER-α K iβA is the K i value for the ligand in ER-β; the ligand also having the structure or a pharmaceutically acceptable salt thereof, wherein L 1 is ═C(R 6 )—, —CH(R 6 )—; L 2 is ═C— or —CH—; L 3 is —C(═O)—; L 4 is O; wherein when L 1 is —CH(R 6 )—, L 2 15 —CH—; R a is independently at each occurrence H or (C 1 –C 5 )alkyl; R 1 is phenyl; R 2 is —SR a , —NR a R a , —NC(═O)R a , —NS(═O)R a , —NS(═O) 2 R a , halogen, cyano, haloC 1-6 alkyl, —CO 2 R a , —C(═O)R a , —C(═O)NHR a , nitro, —S(═O)R a or —S(═O) 2 R a ; R 3 , R 4 and R 5 are independently selected from —R a , —OR a , —SR a , —NR a R a , —NC(═O)R a , —NS(═O)R a , —NS(═O) 2 R a , halogen, cyano, haloC 1-6 alkyl, —CO 2 R a , —C(═O)R a , —C(═O)NHR a , nitro, —S(═O)R a or —S(═O) 2 R 2 ; and R 6 is H, C 1-5 alkyl, phenyl or haloC 1-6 alkyl.