Patent ID: 7595327

Claim:
A compound having the Formula I: or and an entiomer or diastereomer or a pharmaceutically acceptable salt thereof, wherein: R 2 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; wherein each of said C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl optionally is substituted with up to four independently selected R 14 groups; R 3 is 2-methylquinolin-4-yl, 1-H-1,2,3-benzotriazol-1-yl, 1-H-benzimidazol-5-yl, or 2,1,3-benzoxadiazol-5-yl; each optionally substituted with up to four independently selected R 14 groups; R 4 and R 5 are each independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; wherein each of said C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl is optionally substituted with up to four independently selected R 15 groups; R 8 and R 9 are each independently hydrogen, OH, OR 17 , —OCOR 12 , —OC(O)NR 12 R 13 , —NR 12 R 13 , —N(R 12 )COR 13 , —N(R 20 )COOR 12a , —N(R 20 )SO 2 R 13a , —N(R 20 )CONR 12 R 13 , halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, phenyl, naphthyl; wherein each of said C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 3 -C 8 cycloalkyl, phenyl, or naphthyl is optionally substituted with up to four independently selected R 16 groups; each R 14 , R 15 and R 16 is independently halogen, NO 2 , CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, —OR 17 , COR 12 , —OCOR 12 , C 1-6 haloalkyl, C 1-6 perhaloalkyl, CONR 12 R 13 , —S(O) n R 13a —OPO(OR 12a )OR 12a , —PO(OR 12a )R 13 , —OC(O)OR 12a , —O—C 1-6 alkyl-NR 12 R 13 , —OC(O)NR 12 R 13 , —C(O)NR 12 OR 12a , —COOR 12a , —NR 12 R 13 , —N(R 20 )—C 1-6 alkyl—NR 12 R 13 , —N(R 12 )COR 13 , —N(R 20 )COOR 12a , —SO 2 NR 12 R 13 , —N(R 20 )SO 2 R 13a , —N(R 20 )CONR 12 R 13 , —N(R 20 )C(═NR 13 )NR 12 R 13 , —N(R 20 )C(═NR 13 )N(SO 2 R 13a )R 13 , —SO 2 NHCN, —SO 2 NHCONR 12 R 13 , aryl, phenyl, C 1-6 alkyl —OR 22 , —C 1-6 alkyl —SR 22 , —C(═NR 13 )—, CSR 12 , or —C(═NR 13 )NR 12 R 13 ; each R 12 and R 13 is, independently, H, OR 12a , C 1-6 alkyl, C 2 -6 alkenyl, C 2-6 alkynyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 perhaloalkyl, C 3-8 cycloalkyl, aryl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, C 1-6 haloalkoxy, C 1-6 perhaloalkoxy, or aralkyl; each R 12a is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-8 perfluoroalkyl, C 3-8 cycloalkyl, aryl, or aralkyl; each R 13a is, independently, H, OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 perfluoroalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, aryl, or aralkyl; each R 20 is independently H or C 1-6 alkyl; each R 17 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 perhaloalkyl, C 3-8 cycloalkyl, aryl, or aralkyl; each R 22 is independently H or C 1-3 alkyl; E is —C═C—; X is O; and n is 0, 1 or 2.