Patent ID: 8614229

Claim:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is —CH 2 —; R 2 is —C(O)OH or —C(O)Oalkyl; R 3 is: R 4 , R 5 , R 6 and R 7 are each, independently, H, alkyl, —[C(R 12 ) 2 ] q -cycloalkyl, —[C(R 12 ) 2 ] q -heterocycloalkyl, haloalkyl, halo, —OH, —OR 9 or —N(R 9 ) 2 ; each occurrence of R 9 is independently H, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl or hydroxyalkyl; R 10 is: each occurrence of R 12 is independently H, halo, —N(alkyl) 2 , —OH, —O-alkyl, alkyl, cycloalkyl or heterocycloalkyl, or two R 12 groups, together with the carbon atoms to which they are attached, join to form a cycloalkyl, heterocycloalkyl or C═O group; R 13 is H, F, Br or Cl; R 14 represents up to 4 optional and additional substituents, each independently selected from alkyl, cycloalkyl, CF 3 , —CN, halo, —O-alkyl, —O-haloalkyl, —NHSO 2 -alkyl, —NO 2 , —C(O)NH 2 , —C(O)NH-alkyl, —C(O)OH, —OH, —NH 2 , —SO 2 -alkyl, —SO 2 NH-alkyl, —S-alkyl, —CH 2 NH 2 , —CH 2 OH, —SO 2 NH 2 , —NHC(O)-alkyl, —C(O)O-alkyl, —C(O)-heterocycloalkyl or heteroaryl; each occurrence of R 15 is independently alkyl, cycloalkyl, CF 3 , —CN, halo, —O-alkyl, —O-haloalkyl, —NHSO 2 -alkyl, —NO 2 , —C(O)NH 2 , —C(O)NH-alkyl, —C(O)OH, —OH, —NH 2 , —SO 2 -alkyl, —SO 2 NH-alkyl, —S-alkyl, —CH 2 NH 2 , —CH 2 OH, —SO 2 NH 2 , —NHC(O)-alkyl, —C(O)O-alkyl, —C(O)-heterocycloalkyl or heteroaryl; each occurrence of q is independently an integer ranging from 0 to 4; and represents a pyridyl group, wherein the ring nitrogen atom can be at any of the five unsubstituted ring atom positions.