Patent ID: 8828959

Claim:
A method of inhibiting angiogenesis to treat diseases selected from the group consisting of rheumatoid arthritis, Crohn's disease, hyperstimulation of the ovary, endometritis associated with neovascularization, vascular inflammation, Raynaud's disease and Raynaud's phenomena, aneurysm, thrombophlebitis, lymphangitis, lymphedema, tissue cicatrization and repair, angina, age-related macular degeneration and osteoporosis comprising administering a pharmaceutically effective amount of a composition comprising at least one active molecule which inhibits expression of a nucleic acid molecule of a gene coding for protein IRS-1 selected from the group consisting of: i) an antisense sequence of a coding region of SEQ ID NO. 28 comprising at least twelve contiguous nucleotides, and ii) SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15, SEQ ID NO. 16, SEQ ID NO. 17, SEQ ID NO. 18, SEQ ID NO. 19, SEQ ID NO. 20, SEQ ID NO. 21, SEQ ID NO. 22, SEQ ID NO. 23, and fragments thereof comprising at least 12 contiguous nucleotides.