Patent ID: 7682669

Claim:
A method for immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising: preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent; applying the base coat mixture directly to the implantable medical device; polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization; applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer; and immobilizing the anti-thrombogenic material directly to chemically functional groups in the binding material within the base coat layer on the surface of the medical device, wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and wherein the anti-thrombogenic material is selected from the group consisting of glycosaminoglycans, superoxide dismutase mimetic (SODm) grafted to heparin, and combinations thereof.