Patent ID: 7273932

Claim:
A composition for use in regulating hormones of a host, comprising at least one antisense oligonucleotide that is complementary to a nucleotide sequence of a follicle-stimulating hormone receptor (FSHR) transcript; wherein the antisense oligonucleotide comprises a monomer selected from the group consisting of a deoxyribonucleoside, a ribonucleoside, an alpha-anomeric deoxyribonucleoside and an alpha-anomeric ribonucleoside; wherein the FSHR transcript is specific to a mammalian ovarian granulosa cell; wherein the antisense oligonucleotide has a nucleotide sequence capable of forming a stable duplex with a portion of the FSHR transcript wherein the portion is lying within about 50 nucleotides from the translation initiation codon of the target nucleotide sequence; wherein the antisense oligonucleotide is an oligomer of at least 18 nucleotide residues and is less than 60 nucleotides; wherein the antisense oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:4.