Patent ID: 7476679

Claim:
A compound represented by the formula: wherein M is hydrogen, halogen, C 1 -C 4 alkyl, CN, OC 1-8 alkyl, OC 3-8 alkenyl, OC 3-8 alkynyl, or OC 1-8 alkylaryl; R 1 is C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylaryl, (S) 1 is hydrogen, CH 2 CO 2 H, CH 2 CO 2 CH 3 , or CH 2 CO 2 C 2 H 5 ; (S) 2 is hydrogen, CH 3 , C 2 H 3 , CH 2 C 6 H 5 , or CH 2 CH 2 C 6 H 5 ; R 2 is ═O, hydrogen, NR 7 R 8 , X is NR, O, or S; Y is OH, OR 9 , C 1-8 alkyl, F, Cl, Br, CF 3 , or CN; R is hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylaryl, or CO 2 R 9 W is hydrogen, OH, OCOR 9 , N(R 4 ) 2 , NR 3 COR 9 , NR 3 SO 2 R 9 , NR 3 CO 2 R 9 , CONH 2 , or NHCHO; Z is NR3, O, or S; n is 1, 2, or 3; m is 1, 2, 3, or 4; j is 2, 3, or 4; k is 1 or 2; each R 3 is, independently, C 1-3 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylaryl, CH 2 Y, or CO 2 R; each R 4 is, independently, hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, or C 1-8 alkylaryl; R 5 and R 6 are each, independently, hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylcycloalkyl, or C 1-8 alkylaryl; R 7 and R 8 are each, independently, hydrogen, C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, C 1-8 alkylcycloalkyl, or C 1-8 alkylaryl, R 9 is C 1-8 alkyl, C 3-8 alkenyl, C 3-8 alkynyl, or C 1-8 alkylaryl, or a pharmaceutically acceptable salt thereof and inclusive of stereoisomers and wherein the compound may be isotopically labeled.