Patent ID: 7173029

Claim:
A fused heteroaryl compound of formula (Ib): wherein: B is a thiophene ring; R 1 is a lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl which may have one or more substituents, heteroaryl which may have one or more substituents, halogen, â€”NO 2 , â€”CN, a halogenated lower alkyl, â€”ORb, â€”SRb, â€”SO 2 â€”Rb, â€”SOâ€”Rb, â€”COORb, â€”COâ€”Rb, â€”CONRaRb, â€”SO 2 NRaRb, â€”NRaRb, â€”NRaâ€”CORb, â€”NRaâ€”SO 2 Rb, â€”Oâ€”COâ€”NRaRb, â€”NRaCOâ€”COORb, â€”NRaCOORb, â€”NRaCO-lower alkylene-aryl, â€”NRaâ€”SO 2 -lower alkylene-aryl, â€”NRa-lower alkylene-aryl, -lower alkylene-ORb, -lower alkylene-NRaRb, â€”CO-a nitrogen-containing saturated heterocyclic group, â€”CONRa-lower alkylene-ORb, â€”CONRa-lower alkylene-NRcRb, â€”CONRa-lower alkylene-nitrogen-containing saturated heterocyclic group, â€”O-lower alkylene-ORb, â€”O-lower alkylene-NRaRb, â€”O-lower alkylene-nitrogen-containing saturated heterocyclic group, â€”O-lower alkylene-O-lower alkylene-ORb, â€”O-lower alkylene-O-lower alkylene-NRaRb, â€”O-lower alkylene-NRc-lower alkylene-NRaRb, â€”NRc-lower alkylene-NRaRb, â€”N(a lower alkylene-NRaRb) 2 , â€”CONRaâ€”ORb, â€”NRaâ€”COâ€”NRbRc, or â€”OCORb; R 2 and R 3 are combined together with the N atom adjacent thereto to form a morpholino; each of Ra and Rc, which may be the same or different, represents H or lower alkyl; Rb is H, lower alkyl, cycloalkyl, aryl which may have one or more substituents or a heteroaryl which may have one or more substituents; n is 1; W is N; R 4b is -(aryl which may have one or more substituents), â€”(a heteroaryl which may have one or more substituents and which is a 5 or 6 membered monocyclic heteroaryl containing 1 to 4 heteroatoms selected from N and S or a bicyclic heteroaryl which is a monocyclic heteroaryl as defined above is fused to a benzene ring), or a pharmaceutically acceptable salt thereof.