Patent ID: 7306789

Claim:
A method of treating an alopecia selected from the group consisting of alopecia areata, hair loss secondary to chemotherapy or radiation treatment, stress-related hair loss, self-induced hair loss, and scarring alopecia, the method comprising administering to a mammal who has experienced or is considered at risk for experiencing the alopecia an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is O, S or NH; R and R 1 are each independently selected from H and C 1 -C 4 alkyl or taken together represent C 2 -C 6 alkylene; R 2 is H or C 1 -C 4 alkyl; R 3 is (a) a 6-membered heterocyclic ring containing 1 or 2 N heteroatoms, said ring being linked to X by a ring carbon atom, optionally benzo-fused and optionally substituted, including in the benzo-fused portion, by C 1 -C 6 alkyl, hydroxy, —OR 5 , halo, —S(O) m R 5 , oxo, amino, —NHR 5 , —N(R 5 ) 2 , cyano, —CO 2 R 5 , —CONH 2 , —CONHR 5 , or —CON(R 5 ) 2 , with the proviso that R 3 is not an N—(C 1 -C 6 alkyl)pyridonyl group; (b) when X is NH, a group of the formula: (c) when X is NH, a group of the formula: R 4 is phenyl substituted by a hydroxy group and optionally further substituted by 1 or 2 substituents each independently selected from hydroxy, C 1 -C 6 alkyl, —OR 5 , halo, cyano and nitro; R 5 is C 1 -C 6 alkyl; R 6 is —OR 5 , —NHR 5 , —N(R 5 ) 2 , —SR 5 or —NHR 9 ; R 7 is cyano; R 8 is —OR 5 , —NHR 5 , —N(R 5 ) 2 or —NHR 9 ; R 9 is phenyl optionally substituted by C 1 -C 6 alkyl, hydroxy, —OR 5 , halo, cyano or nitro; and m is 0, 1, or 2.