Patent ID: 8043616

Claim:
A polypeptide according to formula (I): (Rg-Lk-V2-Hg-C H 2-C H 3) (t) (I) where Rg is a mammalian sRAGE sequence, Lk is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, C H 2 is an immunoglobulin heavy chain C H 2 constant region and C H 3 is an immunoglobulin heavy chain C H 3 constant region and t is independently an integer from 1 to 10, wherein Cys220 of Hg is substituted with Ala, and Leu234 and Leu235 of C H 2-C H 3 are mutated to Ala234 and Ala235.