Patent ID: 8198443

Claim:
A process for the manufacture of a compound of the structure wherein R 2 ═CH 2 R 3 wherein R 3 is H or NHR′″ where R′″=formyl wherein 1 equivalent of an α-formyl-propionitrile salt or an α-formyl-β-formylaminopropionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of an additional Lewis acid at the following reaction conditions: a. a reaction temperature of 65 to 200° C.; b. a pressure of 1 to 10 bar; c. a reaction time of 0.5 to 20 hours; d. a concentration of 1-50 wt.-% α-formylpropionitrile salt or α-formyl-β-formylaminopropionitrile salt in a corresponding solvent; e. stirring between 100 and 900 rps; and f. under air or nitrogen or argon or mixtures thereof.