Patent ID: 7592008

Claim:
An immunogenic composition comprising stable, soluble nanoscale discoid particles, which particles comprise a membrane scaffold protein, at least one hydrophobic or partially hydrophobic antigen molecule from a virus, a bacterium, fungus, protozoan, parasite, a human neoplastic cell or an animal neoplastic, tumor or cancer cell, and at least one phospholipid, wherein said immunogenic composition optionally further comprises an immunological adjuvant, and wherein said membrane scaffold protein is a derivative or a truncated form of human apolipoprotein A1, is amphipathic and wherein said membrane scaffold protein forms at least one alpha helix, and lacks the N-terminal globular domain of human apolipoprotein A1 (amino acids 8-50 of SEQ ID NO:2) and wherein the membrane scaffold protein is that of SEQ ID NO:6 or SEQ ID NO:9.