Patent ID: 8530674

Claim:
A process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine, comprising steps of: performing an N,O-cleavage reaction on a compound represented by formula (II), to form (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol as shown in formula (III), reacting the (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol with halonaphthalene in DMSO to form (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine represented by the following formula, wherein R is a hydrogen atom, C 1-8 alkyl or C 6-10 aryl; and halo is F, Cl, Br or I, wherein KOR 1 is used in the step of reacting the (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol with halonaphthalene, and wherein R 1 is C 1-6 alkyl.