Patent ID: 6949580

Claim:
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ht is pyrazol-3-yl, having R 3 and QR 4 substituents; R 1 is selected from R; T is a valence bond; each R is independently selected from hydrogen or an optionally substituted aliphatic group having one to six carbons; R 2 is selected from phenyl or naphtyl; R 3 is selected from R, OH, OR, N(R 8 ) 2 , F, Cl, or CN; Q is a valence bond, J, or an optionally substituted C 1-6 alkylidene chain wherein up to two nonadjacent carbons of the alkylidene chain are each optionally and independently replaced by J; J is selected from —C(═O)—, —CO 2 —, —C(O)C(O)—, —NRCONR 8 —, —N(R)N(R 8 )—, —C(═O)NR 8 —, —NRC(═O)—, —O—, —S—, —SO—, —SO 2 —, —N(R)O—, —ON(R 8 )—, —OC(═O)N(R 8 )—, —N(R)COO—, —SO 2 N (R 8 )—, —N(R)SO 2 —, or —N(R 8 )—; R 4 is selected from —R 8 , —R 5 , —NH 2 , —NHR 5 , —N(R 5 ) 2 , or —NR 5 (CH 2 ) y N (R 5 ) 2 ; each R 5 is independently selected from R 6 , R 7 , —(CH 2 ) y CH(R 6 )(R 7 ), —(CH 2 ) y R 6 , —(CH 2 ) y CH(R 6 ) 2 , —(CH 2 ) y CH(R 7 ) 2 , or —(CH 2 ) y R 7 ; y is 0-6; each R 6 is an optionally substituted group independently selected from an aliphatic, aryl, aralkyl, aralkoxy, heteroaryl, heteroarylalkyl, heteroarylalkoxy, heterocyclyl, heterocyclylalkyl, or heterocyclylalkoxy, group; each R 7 is independently selected from an optionally substituted aliphatic, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, or alkoxycarbonyl; each R 8 is independently selected from R or two R 8 on the same nitrogen taken together with the nitrogen optionally form a four to eight membered, saturated or unsaturated heterocyclic ring having one to three heteroatoms; and each substitutable ring nitrogen is independently substituted by R, NR 2 , COR, CO 2 (C 1 -C 6 optionally substituted alkyl), SO 2 (C 1 -C 6 optionally substituted alkyl), CONR 2 , or SO 2 NR 2 ; provided that: (a) TR 2 and QR 4 are not the same; (b) TR 2 and R 3 are not the same; and (b) when Ht is pyrazol-3-yl and R 1 and R 3 are both hydrogen, then TR 2 is other than methyl when QR 4 is phenyl in the 4-position.