Patent ID: 8524281

Claim:
A pharmaceutically acceptable composition of (i) spheroid particles comprising: (a) 30-70 weight percent of (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide or a pharmaceutically acceptable salt thereof as an active ingredient; (b) 20-30 weight percent of one or more fillers; and (c) 5-15 weight percent of one or more wetting agents, said spheroid particles comprising 70-83 weight percent of the total composition; (ii) a sub-coating applied to said spheroid particles further comprising 1-4 weight percent of one or more pharmaceutically acceptable cellulose based polymers and (iii) 16-30 weight percent of one or more pharmaceutically acceptable polymers as an enteric coating applied to said sub-coating, said coating components (ii) and (iii) comprising 17-30 weight percent of the total composition; wherein the enteric coated composition has an AUC/C max ratio that is the same as or less than the AUC/C max ratio of an immediate release formulation of the active ingredient without enteric coating.