Patent ID: 8865708

Claim:
A composition suitable for decreasing p97 ATPase activity and/or degradation of a p97 dependent ubiquitin-proteasome substrate, comprising: a compound of Formula VII, IX, XII, XX, XXI or XLIII, or a pegylated analog of the compound, a pharmaceutically acceptable salt of the compound or the analog, or any regioisomer or stereoisomer of the compound: Wherein, for Formula VII, R 1 , n, X, and Y are selected from the group consisting of combinations listed in Table 7: TABLE 7 Cpd # R1 n X Y VII-3 H 1 O H, H VII-4 H 1 NH H, H VII-5 8-OMe 1 NH H, H VII-6 8-OMe 1 O H, H VII-7 8-OH 1 O H, H VII-8 8-Ph 1 O H, H VII-9 8-OCH 2 CH 2 OH 1 O H, H VII-10 8OCH 2 CH 2 NEt 2 1 O H, H VII-11 8-p-OMePh 1 O H, H VII-12 8-OMe 1 NMe H, H VII-13 8-OMe 1 NCOMe H, H VII-14 8-OCH 2 CH 2 OMe 1 O H, H VII-16 8-OMe 0 NH NH VII-17 8-OMe 0 O Y,Y together form one O as oxygen of carbonyl incorporating both Y's VII-15 8-n-Butyl 1 O H, H Wherein, for Formula XII, R 4 is selected from the group consisting of the moieties listed in Table 10: TABLE 10.1 Cpd # R4 Cpd # R4 XII-4 XII-8 XII-7 XII-10 XII-2 XII-11 XII-9 Wherein for Formula XXI, R 1 is 5,6-dimethyl;