Patent ID: 7652051

Claim:
A compound having the structure (B) or an N-oxide, N,N′-dioxide, N,N′,N″-trioxide, or a pharmaceutically acceptable salt thereof: wherein: each of Z 1 , Z 2 and Z 3 is independently selected from a group consisting of N, and N—R 4 , wherein R 4 is hydrogen or lower alkyl, X is absent or is NH; and Y is absent or is selected from a group consisting of the following moieties: R 1 is an unsubstituted or a substituted C 3 -C 12 heteroaryl having 1-3 heteroatoms; R 2 is selected from a group consisting of hydrogen, halogen, C 1 -C 18 alkyl, —OH, NO 2 , —CN, C 1 -C 18 alkoxy, —NHSO 2 R 5 , —SO 2 NHR 5 , —NHCOR 5 , —NH 2 , —NR 5 R 6 , —S(O)R 5 , S(O) 2 R 5 , —CO 2 R 5 , —CONR 5 R 6 , wherein R 5 and R 6 are independently selected from a group consisting of hydrogen, a C 1 -C 18 alkyl, and a substituted C 1 -C 12 alkyl; and R 3 is selected from a group consisting of a C 1 -C 18 alkyl, a substituted C 1 -C 12 alkyl, a C 1 -C 12 cycloalkyl, a substituted C 1 -C 12 cycloalkyl, a substituted C 3 -C 10 cycloalkyl having 0-3 heteroatoms, an C 6 -C 12 aryl, a substituted C 6 -C 12 aryl, a heterocycle, a substituted heterocycle, a C 3 -C 12 heteroaryl having 1-3 heteroatoms, a substituted C 3 -C 12 heteroaryl having 1-3 heteroatoms, a C 7 -C 24 aralkyl, a substituted C 7 -C 24 aralkyl, a C 7 -C 24 alkylaryl, and a substituted C 7 -C 24 alkaryl.