Patent ID: 8143415

Claim:
A process for making a compound having the formula A.1, wherein R 1 is hydrogen or forms a bond with Z 1 ; Z 1 is hydroxyl, cyano, is taken together with R 1 to form a bond, or is OR p ; Z 2 is hydroxyl or OR p ; wherein each R p is a protecting group; R 2 , R 3 , and R 5 are independently, hydrogen, alkyl, substituted alkyl, aryl or substituted aryl; or R 2 and R 3 may be taken together with the carbon to which they are attached to form an optionally-substituted cycloalkyl; R 4 is hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, aryl, or substituted aryl; R 6 is hydrogen, alkyl or substituted alkyl; R 12 is H, alkyl, substituted alkyl, or halogen; and R 13 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; which comprises, reacting a compound having the formula (C), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 12 , R 13 , Z 1 and Z 2 are as described above, with at least one halogenating agent to provide compounds having the formula (B.1) and/or (B.2), wherein Y is halogen and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 12 , R 13 , Z 1 and Z 2 are as described above followed by treatment of compounds (B.1) and/or (B.2) with base to provide the compound of formula A.1.