Patent ID: 7429665

Claim:
A compound of formula I or a pharmaceutical acceptable salt thereof, wherein Z is R 1 is each independently selected from a group consisting of hydrogen or halogen; R 2 is hydrogen or C 1 to C 8 alkyl; HET 1 is 2,3-pyrazole which may be optionally substituted with at least one R 4 ; R 4 is C 1 to C 8 alkyl, C 3 to C 8 haloalkyl, or a C 1 to C 8 alkyl substituted with a substituent selected from a group consisting of —OR 8 and —NR 8 R 8 , wherein R 8 is independently selected from a group consisting of hydrogen and C 1 to C 8 alkyl; HET 2 is a 4-pyridyl, which may be optionally substituted with at least one R 5 ; R 5 is independently selected from a group consisting of halogen, C 1 to C 8 alkyl and —NR 7 R 7 ; B 1 and B 2 are adjacent atoms in Het 1 and are both carbon; bond j is a covalent bond between Z and B 2 ; bond k is a bond in Het 1 between B 1 and B 2 ; X is oxygen or C(R 2 ) 2 and X 1 is C(R 2 ) 2 ; Y is carbon substituted with R 8 ; wherein each R 6 is independently selected from a group consisting of hydrogen, halogen, hydroxyl, C 1 to C 8 alkoxy and NR 7 R 7 ; wherein each R 7 is independently selected from a group consisting of hydrogen and C 1 -C 8 alkyl; p is 1, 2 or 3.