Patent ID: 7108989

Claim:
A method of screening for a biological modifier that modulates apoptosis-induced cell death comprising the steps of: a) providing a cell in vitro; b) introducing into the cell a polynucleotide sequence encoding a CDN-1 amino acid sequence comprising: i) the amino acid sequence of SEQ ID NO:7; ii) a fragment of SEQ ID NO:7 lacking up to about the first 70 amino acids of SEQ ID NO:7; iii) a fragment of SEQ ID NO:7 truncated after about amino acid position 112; or iv) an amino acid sequence that is greater than 97% identical to SEQ ID NO:7, wherein the amino acid sequence modulates apoptosis in a cell; c) contacting the cell with a potential biological modifier; and d) measuring the level of apoptosis-induced cell death.