Patent ID: 7759357

Claim:
A compound of formula wherein R 1 is halogen or halo(C 1-4 )alkyl, R 2 is hydrogen, halogen or halo(C 1-4 )alkyl, R 3 is halogen or halo(C 1-4 )alkyl, R 4 is hydrogen, (C 1-8 )alkyl, hydroxy(C 1-6 )alkyl or a group of formula —CO—R 5 , —CO—(CH 2 ) m —OR 6 , —CO—CO—R 7 , —CO—CO—OR 8 , —CO—N(R 9 R 10 ), —CO—(CH 2 ) n —CO—R 11 , —CO—(CHR 15 )—O—(CH 2 ) o —CO—R 11 , —CO—(CH 2 ) p —O—(CH 2 ) q —O—(CH 2 ) r —R 16 , —CO—O—(CH 2 ) s —O—CO—R 17 , —CO—O—(CH 2 ) t —N(R 18 R 19 ), —CO—O—(CH 2 ) u —NH—CO—CH(NH 2 )—R 20 , or —CO—O—(CH 2 ) w —NH—CO—R 17 , wherein R 5 is hydrogen, (C 1-8 )alkyl, (C 3-8 )cycloalkyl, amino, (C 1-4 )alkylamino, di(C 1-4 )alkylamino, aryl or heterocyclyl which is a 5 or 6-membered heterocyclic ring system having 1 to 4 heteroatoms selected from N, O or S, R 6 is hydrogen, (C 1-4 )alkyl, (C 3-8 )cycloalkyl, aryl, (C 1-4 )alkyl substituted by heterocyclyl which is a 5 or 6-membered heterocyclic ring system having 1 to 4 heteroatoms selected from N, O or S, amino(C 1-6 )alkyl, (C 1-4 )alkylamino(C 1-6 )alkyl, di(C 1-4 )alkylamino(C 1-6 )alkyl, hydroxy(C 1-6 )alkyl, hydroxy(C 1-4 )alkylamino(C 1-6 )alkyl or an amino acid residue, R 7 and R 8 independently of each other are (C 1-4 )alkyl, (C 3-8 )cycloalkyl, aryl or heterocyclyl which is a 5 or 6-membered heterocyclic ring system having 1 to 4 heteroatoms selected from N, O or S, R 9 and R 10 independently of each other are hydrogen or (C 1-4 )alkyl or one of R 9 and R 10 is hydrogen and the other is (C 3-8 )cycloalkyl, (C 1-4 )alkyl, aryl or heterocyclyl, R 11 is (C 1-4 )alkyl, —OR 12 , —NR 13 R 14 , an amino acid, an (C 1-4 )alkylester thereof or a di(C 1-4 )alkylester thereof, R 12 is hydrogen or (C 1-4 )alkyl, R 13 and R 14 independently of each other are hydrogen, (C 1-4 )alkyl, amino(C 1-6 )alkyl, (C 1-4 )alkylamino(C 1-6 )alkyl, di(C 1-4 )alkylamino(C 1-6 )alkyl, R 15 is hydrogen or (C 1-4 )alkyl, R 16 is hydrogen, (C 1-4 )alkyl, carboxyl or carboxylic ester, R 17 is amino(C 1-4 )alkyl, (C 1-4 )alkylamino(C 1-4 )alkyl or di(C 1-4 )alkylamino(C 1-4 )alkyl, R 18 is hydrogen or (C 1-4 )alkyl, R 19 is hydroxy(C 1-4 )alkyl, R 20 is (C 1-4 )alkyl or hydroxy(C 1-4 )alkyl, m is 0 to 4, n is 2 to 8, o is 0 to 4, p is 0 to 4, q is 1 to 8, r is 0 to 4, s is 1 to 4, t is 1 to 4, u is 1 to 6 and w is 1 to 6,or a salt thereof.