Patent ID: 8257699

Claim:
A pharmaceutical composition, comprising a soluble neutral active human hyaluronidase glycoprotein (sHASEGP); and an Alpha 1-proteinase inhibitor, wherein: the hyaluronidase glycoprotein is a neutral active soluble hyaluronidase polypeptide (sHASEGP) containing at least one N-linked sugar moiety that is covalently attached to an asparagine residue of the polypeptide; the hyaluronidase polypeptide does not comprise the complete sequence of amino acids set forth in SEQ ID NO:1; and the hyaluronidase polypeptide consists of: a) a sequence of amino acid residues contained within SEQ ID NO:1 that includes at least amino acids 36-464 of SEQ ID NO:1, wherein the polypeptide is truncated within the C-terminus of SEQ ID NO:1 at a C-terminal amino acid residue selected from among 467, 477, 478, 479, 480, 481, 482, 483 and 494 of SEQ ID NO:1; or b) a sequence of amino acid residues that has at least 91% amino acid sequence identity with a sequence of amino acids set forth in a).