Patent ID: 8637074

Claim:
A method of making phospholipid liposomes having an average diameter of between 0.01 and 10.0 microns, comprising the steps of: a.) providing a phospholipid material, hydrophobic drug and a first fluid consisting of a supercritical, critical or near-critical fluid; and, forming a first hydrophobic drug solution of said phospholipid material, hydrophobic drug in said first fluid; b.) providing an aqueous solution and a hydrophilic drug and forming a second hydrophilic drug solution; c.) depressurizing said first hydrophobic drug solution in the presence of said second hydrophilic drug solution, as said first hydrophobic drug solution exits one or more orifices in the presence of said second hydrophilic drug solution, said phospholipid material, hydrophobic drug, and hydrophilic drug forming phospholipid liposomes having an average diameter between 0.01 and 10.0 microns and said first fluid removed during depressurization.