Patent ID: 7718645

Claim:
A compound having the formula or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein: (a) R 1 is H —(C 1 -C 4 )alkyl, —(C 1 -C 4 )perfluoroalkyl, —(C 1 -C 4 )perfluoroalkoxy, or —(C 1 -C 4 )alkoxy; (b) R 2 and R 3 , taken separately, are independently H, —(C 1 -C 4 )alkyl, or —(C 1 -C 4 )perfluoroalkyl; or R 2 and R 3 , taken together with the carbon to which they are attached, is —(C 3 -C 6 )cycloalkyl; (c) R 4 is H or —(C 1 -C 4 )alkyl; (d) R 5a , R 5b , R 5c and R 5d are each independently H, F, Cl, Br, —(C 1 -C 4 )alkyl, —OH or —O—(C 1 -C 4 )alkyl; (e) Q is —O— or a bond; (f) A is a —(C 3 -C 6 )cycloalkylene group, a —(C 3 -C 6 )cycloalkenylene group or phenylene; (g) Z is —C(R 6a )(R 6b )— or a bond wherein R 6a and R 6b are each independently —H or —(C 1 -C 4 )alkyl, or R 6a and R 6b , taken together with the carbon to which they are attached, is a —(C 3 -C 6 )cycloalkyl; (h) R 7 is C(O)R 8 , cyano, hydroxyl, —(C 1 -C 4 )alkoxy, —(C 1 -C 4 )perfluoroalkoxy or a carboxylic acid mimic; (i) R 8 is —OR 9 or NHR 10 ; (j) R 9 is —H, —(C 1 -C 4 )alkyl, or —(C 1 -C 4 )perfluoroalkyl; and (k) R 10 is —H, —(C 1 -C 4 )alkyl, tetrazolyl or S(O) 2 CF 3 .