Patent ID: 8440720

Claim:
A method for treating an influenza virus-affected disease state or infection comprising the step of administering to a subject in need thereof a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is amino, amino(C 1 -C 3 )alkyl, nitro, nitro(C 1 -C 3 )alkyl, formamidinyl, guanidinyl, —CH(OH)CH 2 NO 2 , (C 1 -C 3 )alkylamino, or a five- or six-membered heterocyclic ring; R 2a and R 2b are independently hydrogen, hydroxyl, (C 1 -C 3 )alkyl optionally substituted with halo, (C 1 -C 3 )alkoxy, or halo; or, R 1 together with R 2a or R 2b forms a five- or six-membered optionally substituted carbocyclic or heterocyclic ring; R 3 is hydrogen, halo, hydroxyl, (C 1 -C 3 )alkoxy, thiol, or thio(C 1 -C 3 )alkyl; and, R 4a and R 4b are independently hydrogen, hydroxyl, halo, thiol, thionyl, cyano, (C 1 -C 3 )alkyl optionally substituted with halo, (C 1 -C 3 )alkoxy, oxo, oxime, hydroxy(C 1 -C 3 )alkyl, or R 4a and R 4b together with the carbon atom to which they are both attached form a three- to six-membered carbocyclic or heterocyclic ring, wherein: at least one of R 2a or R 2b ; R 3 ; or R 4a and R 4b are other than hydrogen, or, R 1 includes or is involved in forming a five- or six-membered heterocyclic or carbocyclic ring that is directly bound to the carbon atom to which R 1 is attached wherein the compound is not 3-fluoroadamantan-1-amine.