Patent ID: 7803377

Claim:
An isolated anti-DLL4 antibody comprising six hypervariable region (HVR) sequences: (i) HVR-L1 comprising sequence A1-A11, wherein A1-A11 is RASQDVSTAVA (SEQ ID NO: 10) (ii) HVR-L2 comprising sequence B1-B7, wherein B1-B7 is SASFLYS (SEQ ID NO:I 1) (iii) HVR-L3 comprising sequence C1-C9, wherein C1-C9 is QQSYTGTVT (SEQ ID NO: 18) (iv) HVR-H1 comprising sequence D1-D10, wherein D1-D10 is GFTFTDNWIS (SEQ ID NO: 1); (v) HVR-H2 comprising sequence E1-E18, wherein E1-E18 is GYISPNSGFTYYADSVKG (SEQ ID NO:8) and (vi) HVR-H3 comprising sequence F1-F15, wherein F1-F15 is VYYCARDNFGGYFDY (SEQ ID NO:9).