Patent ID: 7928127

Claim:
A compound of formula I: wherein R 1 is (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, aryl(C 1 -C 6 )alkoxy, heteroaryl(C 1 -C 6 )alkoxy, aryl, heteroaryl, hydroxy, SR 5 , NR 5 R 5 , or absent; R 2 is CH 2 , carbonyl, SO 2 , or OH; L is CH 2 , NR 5 , or O; R 3 and R 4 are each independently hydroxy, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkanoyl, (C 1 -C 6 )alkanoyloxy, aryl, heteroaryl, carboxy, cyano, nitro, halo, trifluoromethyl, trifluoromethoxy, SR 5 , SO 2 N(R 5 ) 2 , NR 5 R 5 , or CO 2 R 5 ; each n is independently 0 to 4; each R 5 is independently H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkanoyl, (C 6 -C 10 )aroyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl, heteroaryl(C 1 -C 6 )alkyl, or a nitrogen protecting group; X is O; D is S, SO, SO 2 , C═N—OH, or carbonyl; E is a direct bond, or (C 1 -C 6 )alkyl; J is S, O, or NR 5 ; G, T, and Q are each independently H, (C 1 -C 6 )alkyl, or cyano; any alkyl, amino, aryl, heteroaryl, or cycloalkyl is optionally substituted with 1 to about 5 (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, aryl, heteroaryl, aryl(C 1 -C 6 )alkyl, heteroaryl(C 1 -C 6 )alkyl, nitro, halo, amino, or hydroxy groups; or a pharmaceutically acceptable salt thereof; provided that when L is CH 2 or O, and R 2 is CH 2 , R 1 is not (C 1 -C 6 )alkyl; when L is O and R 2 is carbonyl, R 1 is not (C 1 -C 6 )alkyl; and when L is NR 5 , R 2 is not CH 2 .