Patent ID: 6936628

Claim:
A method of administering a compound comprising: orally administering to a human one or more compounds of Formula I: wherein: P-Q is a C, C double bond or an epoxide; G is R is selected from the group consisting of H, alkyl, and substituted alkyl; R 1 is selected from the group consisting of R 2 is G 1 is selected from the group consisting of H, halogen, CN, alkyl and substituted alkyl; G 2 is selected from the group consisting of H, alkyl, and substituted alkyl; G 3 is selected from the group consisting of O, S, and NZ 1 ; G 4 is selected from the group consisting of H, alkyl, substituted alkyl, OZ 2 , NZ 2 Z 3 , Z 2 C═O, Z 4 SO 2 , and optionally substituted glycosyl; G 5 is selected from the group consisting of halogen, N 3 , NCS, SH, CN, NC, N(Z 1 ) 3 + , and heteroaryl; G 6 is selected from the group consisting of H, alkyl, substituted alkyl, CF 3 , OZ 5 , SZ 5 , and NZ 5 Z 6 ; G 7 is CZ 7 or N; G 8 is selected from the group consisting of H, halogen, alkyl, substituted alkyl, OZ 10 , SZ 10 , NZ 10 Z 11 ; G 9 is selected from the group consisting of O, S, —NH—NH—, and —N═N—; G 10 is N or CZ 12 ; G 11 is selected from the group consisting of H 2 N, substituted H 2 N, alkyl, substituted alkyl, aryl, and substituted aryl; Z 1 , Z 6 , Z 9 , and Z 11 are independently selected from the group consisting of H, alkyl, substituted alkyl, acyl, and substituted acyl; Z 2 is selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, and heterocycle; Z 3 , Z 5 , Z 8 , and Z 10 are independently selected from the group consisting of H, alkyl, substituted alkyl, acyl, substituted acyl, aryl, and substituted aryl; Z 4 is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, and heterocycle; Z 7 is selected from the group consisting of H, halogen, alkyl, substituted alkyl, aryl, substituted aryl, OZ 8 , SZ 8 , and NZ 8 Z 9 ; and Z 12 is selected from the group consisting of H, halogen, alkyl, substituted alkyl, aryl, and substituted aryl; with the proviso that when R 1 is G 1 , G 2 , G 3 , and G 4 cannot simultaneously have the following meanings: G 1 and G 2 =H, G 3 =O and G 4 =H or Z 2 C═O where Z 2 =alkyl, and with the proviso that when R 1 is G 1 , G 2 or G 5 cannot simultaneously have the following meanings: G 1 and G 2 =H, and G 5 =F; or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof; and orally administering one or more pharmaceutically acceptable acid neutralizing buffers in an amount sufficient to reduce decomposition of said one or more compounds, or said pharmaceutically acceptable salt, solvate, clathrate, hydrate, or prodrug thereof.