Patent ID: 7115598

Claim:
A compound of Formula II: or a pharmaceutically acceptable salt thereof; wherein: each instance of R a is independently halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, cyano, C 3-8 cycloalkyl, hydroxy, C 1-6 alkoxy, carboxy, (C 1-6 alkoxy)carbonyl, C 1-6 acyl, carbamoyl, (C 1-6 alkyl)aminocarbonyl, alkylthio, amino or nitro; n is 0; or n is 1 and R a occurs at the 7- or 8-position; or n is 2 and R a occurs at the 7- and 8-positions; X is a bivalent radical of: a C 1-6 alkane, an optionally-substituted C 6-10 arene, an optionally-substituted 5- to 7-membered heteroarene wherein 1 or 2 ring atoms are heteroatoms, an optionally-substituted (C 6-10 aryl)C 1-6 alkane, or an optionally-substituted heteroaryl(C 1-6 ) alkane in which the heteroaryl portion contains 5 to 7 ring atoms and wherein 1 or 2 of the ring atoms are heteroatoms; R 3 is —CO 2 R d or —CO 2 M, where R d is hydrogen, C 1-6 alkyl or optionally-substituted C 3-8 cycloalkyl, and M is a cation; R 5 is C 3-8 cycloalkyl, C 6-10 aryl, 5- to 7-membered heteroaryl wherein 1 or 2 of the ring atoms are heteroatoms, (C 3-8 cycloalkyl)alkyl, (C 6-10 aryl)alkyl, (heteroaryl)alkyl in which the heteroaryl portion contains 5 to 7 ring atoms and wherein 1 or 2 of the ring atoms are heteroatoms, or 5- to 7-membered saturated or partially unsaturated heterocycle wherein 1 or 2 of the ring atoms are heteroatoms, in which each of the preceding groups is optionally substituted; R 6 is C 3-8 cycloalkyl, C 6-10 aryl, 5- to 7-membered heteroaryl wherein 1 or 2 of the ring atoms are heteroatoms, (C 3-8 cycloalkyl)alkyl, (C 6-10 aryl)alkyl, (heteroaryl)alkyl in which the heteroaryl portion contains 5 to 7 ring atoms and wherein 1 or 2 of the ring atoms are heteroatoms, or 5- to 7-membered saturated or partially unsaturated heterocycle wherein 1 or 2 of the ring atoms are heteroatoms, in which each of the preceding groups is optionally substituted; R 7 is hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl or (C 3-8 cycloalkyl)alkyl; and R 8 is hydrogen or C 1-6 alkyl.