Patent ID: 8871943

Claim:
A process for preparing a compound of Formula (I): or a salt, solvate, isotopologue, or polymorph thereof, wherein: W represents Cl, Br or I; R represents C 1 -C 4 alkyl, cyclopropyl, C 2 -C 4 alkenyl or phenyl substituted with from 0 to 5 substituents independently selected from halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy or C 1 -C 4 haloalkoxy; and R 1 represents C 1 -C 12 alkyl or an unsubstituted or substituted C 7 -C 11 arylalkyl; comprising: (a) fluorinating a compound of Formula (II): wherein A 6 is halogen or R; with a source of fluoride ion to form a compound of Formula (III): wherein B 6 is F or R; and transforming the compound of Formula (III) to a compound of Formula (IV): (b) halogenating a compound of Formula (IV) with a halogen source to form a compound of Formula (V): and (c) coupling a compound of Formula (VI) wherein X is Cl, Br, or I; A 2 is hydrogen or R 1 ; A 3 is hydrogen or W; A 4 is Cl, F, NH 2 , NHCOCH 3 , or a protected amino group; A 5 is F or Cl; with a compound of Formula (VII) R-Met (VII) wherein Met is Zn-halide, Zn—R, tri-(C 1 -C 4 alkyl)tin, copper, or B(OR 2 )(OR 3 ), where R 2 and R 3 are each independently, hydrogen, C 1 -C 4 alkyl, or when taken together form an ethylene or propylene group; in the presence of a transition metal catalyst to form a compound of Formula (VIII): wherein transformation (c) may occur prior to, between, or after transformations (a) and (b).