Patent ID: 7659269

Claim:
A compound of the formula: wherein A is a C 1 -C 4 alkylene group; Z is a bond or C 1 -C 3 alkylene; R 1 is hydrogen, alkyl having 1-6 carbon atoms, halogen, 2-, 3-, or 4-pyridyl, or phenyl, where the phenyl or pyridyl is optionally substituted with up to three groups selected from halogen, hydroxy, C 1 -C 6 alkoxy, C 1 -C 6 alkyl, nitro, amino, or mono- or di(C 1 -C 6 )alkylamino; R 2 , R 3 , R 4 and R 5 are each independently hydrogen, halogen, nitro, or an alkyl group of 1-6 carbon atoms optionally substituted with one or more halogens; OR 7 , SR 7 , S(O)R 7 , S(O) 2 N(R 7 ) 2 , C(O)N(R 7 ) 2 , or N(R 7 ) 2 , wherein each R 7 is independently hydrogen, an alkyl group of 1-6 carbon atoms optionally substituted with one or more halogens, or benzyl, where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, amino, and mono- or di(C 1 -C 6 )alkylamino; phenyl or heteroaryl, where each of which phenyl or heteroaryl is optionally substituted with up to three groups independently selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, amino, and mono- or di(C 1 -C 6 )alkylamino; phenoxy where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, amino, and mono- or di(C 1 -C 6 ) alkylamino; or a group of the formula where J is a bond, CH 2 , oxygen, or nitrogen; and each r is independently 2 or 3; R 6 is hydroxy, benzyloxy, di(C 1 -C 6 )alkylaminoethyloxy, acetoxymethyl, pivaloyloxymethyl, phthalidoyl, ethoxycarbonyloxyethyl, 5-methyl-2-oxo-1,3-dioxol-4-ylmethyl, C 1 -C 6 alkoxy or O − M + where M + represents a cation selected from sodium, potassium, ammonium, magnesium and calcium; R a is hydrogen or C 1 -C 6 alkyl; and Ar represents a phenyl group substituted nitro, SR 7 , S(O)R 7 , or S(O) 2 R 7 wherein R 7 is hydrogen, an alkyl group of 1-6 carbon atoms (which may be substituted with one or more halogens) or benzyl, where the phenyl portion of the benzyl group is optionally substituted with up to three groups independently selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, amino, and mono- or di(C 1 -C 6 )alkylamino.