Patent ID: 8921572

Claim:
A process for preparing 5,5-disubstituted 4,5-dihydroisoxazole-3-thiocarboxamidine salts of the formula (I) where R 1 and R 2 are each independently C 1 -C 6 -alkyl or C 1 -C 4 -haloalkyl; or R 1 and R 2 together form a C 2 -C 5 -alkanediyl chain which may be mono- to tetrasubstituted by C 1 -C 4 -alkyl and/or may be interrupted by oxygen or by optionally C 1 -C 4 -alkyl-substituted nitrogen; R 3 and R 4 are each hydrogen; and A is chlorine or bromine; comprising i) reacting a compound of formula (II) with a chlorinating or brominating reagent to give a compound of formula (III) ii) reacting the compound of formula (III) with thiourea to give the compounds of the formula (I); wherein the compound of formula (II) is prepared in a preliminary stage by reaction of a compound of formula (AII) wherein R a and R b are each independently hydrogen, C 1 -C 6 -alkyl, C 1 -C 4 -alkylcarbonyl, hydroxyimino-C 1 -C 4 -alkyl, phenyl, phenyl-C 1 -C 4 -alkyl or phenyl-C 2 -C 4 -alkenyl, where the phenyl rings may be mono- or polysubstituted by C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, di-C 1 -C 4 -alkylamino, halogen, hydroxyl or nitro; or R a and R b together form a C 2 -C 5 -alkanediyl chain; with a compound of formula (AIII) in the presence of an acid catalyst or of an acid-base catalyst and optionally in the presence of an organic solvent.