Patent ID: 7395111

Claim:
A system for transdermal delivery of a water-insoluble drug comprising: an apparatus for facilitating transdermal delivery of a drug through skin of a subject, wherein the apparatus comprises: a. an electrode cartridge comprising a plurality of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy to the electrodes when the electrodes are in vicinity of the skin, enabling ablation of the stratum corneum in an area beneath the electrodes, thereby generating a plurality of hydrophilic micro-channels; and a patch adapted to be applied to the area on the skin after the plurality of hydrophilic micro-channels is generated, wherein the patch comprises a pharmaceutical composition comprising at least one water-insoluble drug and at least one carrier molecule that enhances the solubility of the drug in an aqueous solution of fluid coming out of the skin when said plurality of hydrophilic micro-channels is generated, the pharmaceutical composition is devoid of a permeation enhancer.