Patent ID: 7611692

Claim:
A compound of the general formula: M—N—O—P—G wherein M is an optical label or a metal chelator optionally complexed with a radionuclide; N is absent, an alpha amino acid, a non-alpha amino acid with a cyclic group or other linking group; O is an alpha amino acid or a non-alpha amino acid with a cyclic group; P is absent, an alpha amino acid, a non-alpha amino acid with a cyclic group, or other linking group; and G is a GRP receptor targeting peptide selected from the group consisting of QWAVGHLM-OH (SEQ ID NO: 1), QWAVGHLM-NH 2 (SEQ ID NO: 1), QWAVGHFL-NH 2 (SEQ ID NO: 11), QRLGNQWAVGHLM-NH 2 (SEQ ID NO: 3), QRYGNQWAVGHLM-NH 2 (SEQ ID NO: 4), QKYGNQWAVGHLM-NH 2 (SEQ ID NO: 5), QWAVGHL-NH-Pentyl (SEQ ID NO: 6), QWSVaHLM-NH 2 (SEQ ID NO: 7), QWAVGHLL-NH 2 (SEQ ID NO: 8), QWAV-Bala-HF-Nle-NH 2 (SEQ ID NO: 9), QWAGHFL-NH 2 (SEQ ID NO: 10), LWAVGSFM-NH 2 (SEQ ID NO: 12), HWAVGHLM-NH 2 (SEQ ID NO: 13), LWATGHFM-NH 2 (SEQ ID NO: 17), LWAVGSFM-NH 2 (SEQ ID NO: 12), EWAVGHLM-NH 2 (SEQ ID NO: 2), QWAVaHLM-NH 2 (SEQ ID NO: 15), QWAVGHFM-NH 2 (SEQ ID NO: 14), Nme-QWAVGHLM-NH 2 (SEQ ID NO: 1), Q-Ψ[CSNH]WAVGHLM-NH 2 (SEQ ID NO: 1), Q-Ψ[CH 2 NH]-WAVGHLM-NH 2 (SEQ ID NO: 1), Q-Ψ[CH═CH]WAVGHLM-NH 2 (SEQ ID NO: 1), α-MeQWAVGHLM-NH 2 (SEQ ID NO: 24), QNme-WAVGHLM-NH 2 (SEQ ID NO: 29), QW-Ψ[CSNH]-AVGHLM-NH 2 (SEQ ID NO: 1), QW-Ψ[CH 2 NH]-AVGHLM-NH 2 (SEQ ID NO: 1), QW-Ψ[CH═CH]-AVGHLM-NH 2 (SEQ ID NO: 1), Q-α-Me-WAVGHLM-NH 2 (SEQ ID NO: 30), QW-Nme-AVGHLM-NH 2 (SEQ ID No: 31), QWA=Ψ[CSNH]-VGHLM-NH 2 (SEQ ID NO: 1), QWA-Ψ[CH 2 NH]-VGHLM-NH 2 (SEQ ID No: 1), QW-Aib-VGHLM-NH 2 (SEQ ID NO: 1), QWAV-Sar-HLM-NH 2 (SEQ ID No: 32), QWAVG-Ψ[CSNH]-HLM-NH 2 (SEQ ID NO: 1), QWAVG-Ψ[CH═CH]-HLM-NH 2 (SEQ ID NO: 1), QWAV-Dala-HLM-NH 2 (SEQ ID NO: 15), QWAVG-Nme-His-LM-NH 2 (SEQ ID NO: 33), QWAVG-H-Ψ[CSNH]-L-M-NH 2 (SEQ ID NO: 1), QWAVG-H-Ψ[CH 2 NH]-LM-NH 2 (SEQ ID NO: 1), QWAVGH-Ψ[CH═CH]-LM-NH 2 (SEQ ID NO: 1), QWAVG-α-Me-HLM-NH 2 (SEQ ID NO: 34), QWAVGH-Nme-LM-NH 2 (SEQ ID NO: 35), and QWAVGH-α-MeLM-NH 2 (SEQ ID NO: 28), wherein at least one of N, O or P is a non-alpha amino acid with a cyclic group and wherein the other linking group of N or P is selected from the group consisting of one or more amino acids, a hydrocarbon chain of the formula R 1 —(CH 2 ) n —R 2 or a combination thereof, wherein n is 0-10, R 1 is selected from the group consisting of H 2 N—, HS— and —COOH; and R 2 is COOH.