Patent ID: 8309563

Claim:
A method for treating a tumor chosen from breast cancer, squamous carcinoma, cell lung cancer, ovarian cancer, stomach cancer, and pancreatic cancer, the method comprising the step of administering to a patient in need of treatment 0.05-100 mg/kg of bodyweight daily a compound of formula I, or a pharmaceutically acceptable salt thereof: wherein, R 1 is selected from: (a) C 1 -C 4 alkyl, C 1 -C 4 alkyl substituted by halogens, C 1 -C 4 alkoxy, C 1 -C 4 alkoxy substituted by halogens, methoxyethoxy, N-morpholinopropoxy, formate, acetate, propionate, butyrate, acylamino or sulfonamide group; (b) Unsubstituted or substituted phenyl, wherein the substituents are 1-3 substituents selected from the group consisting of halogen, —OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkyl-OH, C 1 -C 4 alkoxymethyl, acetate, propionate, butyrate, and sulfonate; (c) Unsubstituted or substituted furyl, and unsubstituted or substituted thienyl, wherein the substituents are 1-3 substituents selected from the group consisting of halogen, —OH, —NH 2 , C 1 -C 4 alkyl, C 1 -C 4 alkoxy, alkoxymethyl, formate, acetate, propionate, butyrate, and sulfonate; or R 1 is wherein R 1 is attached to the ring via oxygen, and X is selected from furyl, pyrrolidyl, pyridyl, oxazoline, thiazolyl, and thienyl; R 1 ′ is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkyl substituted by halogens, C 1 -C 4 alkoxy, and C 1 -C 4 alkoxy substituted by halogens; R 2 is selected from benzyl, mono-, di- or tri-halobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, benzyloxy, mono-, di, -or tri-halobenzyloxy or mono-, di- or tri-halophenylsulfonyl, furylmethyl, pyrrolylmethyl, pyrrolylmethoxy, halogen, C 1 -C 4 alkyl and C 1 -C 4 alkoxy, wherein said phenyl, benzyl, pyridyl, furyl or pyrrolyl may have 1-3 substituents selected from the group consisting of halogen, —OH, —NH 2 , C 1 -C 4 alkyl and C 1 -C 4 alkoxy; R 2 ′ is selected from benzyl, mono-, di- or tri-halobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, mono-, di- or tri-halophenoxy or mono-, di-, or tri-halophenylsulfonyl, furylmethyl, pyrrolylmethyl, pyrrolylmethoxy, halogen, C 1 -C 4 alkyl and C 1 -C 4 alkoxy, wherein said phenyl, benzyl, pyridyl, furyl or pyrrolyl may have 1-3 substituents selected from the group consisting of halogen, —OH, —NH 2 , C 1 -C 4 alkyl and C 1 -C 4 alkoxyl.