Patent ID: 7745443

Claim:
A compound of the formula I, wherein n is the integer zero, 1, 2, 3 or 4; m is the integer zero, 1, 2, 3 or 4; o is the integer zero, 1, 2, 3 or 4; R1 is —(C 1 -C 8 )-alkyl; R2 is —NR 4 R 5 , wherein R 4 and R 5 are identical or different and are hydrogen atom or —(C 1 -C 8 )-alkyl; A is —CO—NH—; B is 1. a covalent bond, 2. a monocyclic or bicyclic 6- to 14-membered aryl, wherein aryl is unsubstituted or mono-, di-, tri- or tetrasubstituted independently of one another by R 3 , 3. (C 3 -C 8 )-cycloalkyl or 4. Het, wherein Het is unsubstituted or mono-, di-, tri- or tetrasubstituted independently of one another by R 3 , D is —NH—; E is Het, wherein Het is a saturated, partially unsaturated or aromatic monocyclic or bicyclic heterocyclic ring system containing 3 to 10 ring atoms of which 1, 2, 3 or 4 are identical or different heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur and wherein Het is unsubstituted or mono-, di-, tri- or tetrasubstituted independently of one another by R 3 ; with the proviso that, when B is a covalent bond and Het is a bicyclic heterocyclic ring system, the ring of Het to which D-(CH 2 ) o — is attached contains at least one hetero atom; R 3 is 1. —(C 1 -C 8 )-alkyl, 2. (C 1 -C 8 )-alkoxy, 3. hydroxyl, 4. trifluoromethoxy, 5. trifluoromethyl, 6. halogen, 7. nitro, 8. —NR 4 R 5 , wherein R 4 and R 5 are as defined above, 9. —(C 1 -C 8 )-alkylcarbonyl, 10. —CN, 11. aminosulfonyl-, 12. amidino, 13. guanidino, 14. tri-((C 1 -C 4 )-alkyl)ammonio-, 15. di-((C 1 -C 8 )-alkyl)amino-, 16. (C 1 -C 8 )-alkylaminosulfonyl-, 17. di-((C 1 -C 8 )-alkyl)aminosulfonyl, 18. —O-Het, wherein Het is unsubstituted or mono-, di-, tri- or tetrasubstituted independently of one another by R 3 and R 3 is as defined above under 1. to 17., or 19. Het-, wherein Het is unsubstituted or mono-, di-, tri- or tetrasubstituted independently of one another by R 3 and R 3 is as defined above under 1. to 17., in all their stereoisomeric forms and their physiologically tolerable salts.