Patent ID: 7767814

Claim:
A compound of formula I: wherein: R 1 is —OR 7 , —NR 7 R 8 , —COOR 7 , —CONR 7 R 8 , or —CH 2 OH; each R 7 is independently H, alkyl, cycloalkyl, alkylcycloalkyl, or aralkyl; each R 8 is independently H, alkyl, aralkyl, or aryl; R 2 and R 3 together with the carbon atoms to which they are attached form a fused carbocycle, R 4 is alkyl, and R 5 is H; R 6 is H or —(CHR 9 ) m W; each R 9 is independently H, alkyl, cycloalkyl, alkylcycloalkyl, aryl, aralkyl or heteroaryl; W is H, alkyl, cycloalkyl, alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, aryl, heteroaryl, —CH 2 OH, —CH 2 OR 7 , or —C(═O)R 10 ; R 10 is —OR 7 or —NR 7 R 11 ; R 11 is H, alkyl, aralkyl, aryl or —(CHR 9 ) n C(═O)R 12 ; R 12 is —OR 7 or —NR 7 R 8 ; m is an integer from 1 to 4; and n is an integer from 1 to 4; provided that: (1) when R 1 is —OCH 3 , R 4 is CH 3 , R 5 is H, and R 2 and R 3 together with the carbon atoms to which they are attached form unsubstituted tetrahydronaphthalene, then W is other than H, alkyl, or phenyl; (2) when R 1 is —OH, then W is heterocycloalkyl, alkylheterocycloalkyl, —CH 2 OH, or —C(═O)R 10 ; and (3) when R 1 is —OH and W is heterocycloalkyl or alkylheterocycloalkyl in which the heterocyclic ring moiety of the heterocycloalkyl or alkylheterocycloalkyl contains only one heteroatom, wherein the heteroatom is nitrogen, then the heterocyclic ring moiety is connected to —(CHR 9 ) m — through a heterocyclic ring carbon atom; or a stereoisomer, pharmaceutically acceptable salt, or N-oxide thereof.