Patent ID: 7737157

Claim:
A compound of the following formula: wherein: X is O, S, or NR i , in which R i is H, alkyl, alkylcarbonyl, aminocarbonyl, or aminosulfonyl; each of Q 1 , Q 2 , and Q 3 , independently, is N or CR ii , in which R ii is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, CN, alkoxy, or amino; R 1 is NHR iv , R iv being phenyl, pyridyl, indazolyl, or indolinyl, each of which is optionally substituted with alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, —OR, —NRR′, —NRSO 2 R′, —NR—C(O)R′, —NR—C(O)NR′R″, —C(O)NRR′, or —S(O) 2 NRR′; R 2 is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, CN, OR iii , NR iii R iv , C(O)R iii , C(O)OR iii , C(O)NR iii R iv , OC(O)R iii , OC(O)OR iii , OC(O)NR iii R iv , NR iii C(O)R iv , NR iii C(O)NR iv R v , or NR iii C(O)OR iv ; each of R iii , R iv , and R v , independently, being H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and R 4 is C(O)NHR iv , in which R iv is H, alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each of which, except for H, optionally having one to three substituents selected from alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, —OR′″, —NR′″R″″, —NR′″SO 2 R″″, —NR′″—C(O)R″″, —NR′″—C(O)NR′″R″″, —C(O)NR′″R″″, and —S(O) 2 NR′″R″″; each of R′″ and R″″, independently, being H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; or R 1 is H; R 2 is NR iii R iv , in which R iii is H and R iv is aryl or heteroaryl, each of which optionally having one to three substituents selected from alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, —OR, —NRR′, —NRSO 2 R′, —NR—C(O)R′, —NR—C(O)NR′R″, —C(O)NRR′, and —S(O) 2 NRR′; each of R, R′, and R″, independently, being H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and R 4 is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, CN, OR iii , NR iii R iv , C(O)R iii , C(O)OR iii , C(O)NR iii R iv , OC(O)R iii , OC(O)OR iii , OC(O)NR iii R iv , NR iii C(O)R iv , NR iii C(O)NR iv R v , or NR iii C(O)OR iv ; each of R iii , R iv , and R v , independently, being H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and each of R 3 and R 5 , independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, CN, OR iii , NR iii R iv , C(O)R iii , C(O)OR iii , C(O)NR iii R iv , OC(O)R iii , OC(O)OR iii , OC(O)NR iii R iv , NR iii C(O)R iv , NR iii C(O)NR iv R v , or NR iii C(O)OR iv ; each of R iii , R iv , and R v , independently, being H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl.