Patent ID: 6855730

Claim:
A compound having the chemical structure: wherein: A is carbon; Q is R 0 is selected from the group consisting of hydrogen, alkyl, —C(O)R 19 and —C(O)OR 19 R 1 is selected from the group consisting of hydrogen, alkyl, alkoxy, halo, aryl, —(CH 2 ) n OC(O)R 19 ; —C(O)NR 19 ; —C(O)OR 19 and —(CH 2 ) n R 20 , wherein: R 19 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl and aryl; n is 1, 2, 3 or 4; R 20 is selected from the group consisting of hydroxy, halo, —C(O)OR 19 , —OC(O)NR 21 R 22 ; —OC(S)NR 21 R 22 , —OC(O)NHS 2 R 21 R 22 ; —NR 21 R 22 and a heteroalicylic group containing at least one nitrogen atom in the ring, the ring being bonded to the adjacent CH 2 group through the nitrogen atom; R 2 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, trihalomethyl, alkoxy, halo, —(CH 2 ) n R 20 , —SO 2 NR 21 R 22 , —C(O)OR 19 , —C(O)R 19 , —NHC(O)OR 19 , —NR 21 R 22 and —N═CR 23 wherein R 21 and R 22 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic; R 23 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl; R 3 is selected from the group consisting of hydrogen, alkyl, trihalomethyl, alkoxy, aryl, aryloxy, heteraryl, heteroalicyclic, hydroxy, halo, —SO 2 NR 21 R 22 , —NHSO 2 R 19 , —C(O)OR 19 , —NR 21 R 22 and —NHC(O)R 24 , wherein R 24 is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, heteroaryl and heteroalicyclic; R 4 is selected from the group consisting of hydrogen, alkyl, alkoxy and halo; R 5 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, halo, aryl and heteroaryl; R 6 is selected from the group consisting of hydrogen, alkyl, alkoxy, halo, cycloalkyl, aryl and, combined with R 18 , a heteroalicyclic group having the structure wherein y and y′ are independently selected from the group consisting of hydrogen, alkyl and aryl; R 7 is OR 18 , wherein R 18 is selected from the group consisting of alkyl, —(CH) n R 20 and, combined with R 6 or R 8 , a heteroalicyclic group having the structure R 8 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxy, halo, aryl, heteroaryl and, combined with R 18 , a heteroalicyclic ring having the structure R 9 is selected from the group consisting of hydrogen, alkyl, alkoxy, halo and —NR 21 R 22 ; R 10 is selected from the group consisting of alkyl and —C(O)OR 19 ; R 11 is selected from the group consisting of hydrogen, alkyl and —C(O)OR 19 ; R 12 is —(CH 2 ) n R 20 ; and, physiologically acceptable salts thereof.