Patent ID: 7141664

Claim:
An isolated nucleic acid molecule selected from the group consisting of: a) an isolated nucleic acid molecule encoding the amino acid sequence set forth in SEQ ID NO:2, wherein either (i) the amino acid residue at position 75 of SEQ ID NO:2 is any amino acid except proline; (ii) the amino acid residue at position 413 of SEQ ID NO:2 is any amino acid except glycine; or (iii) the amino acid residue at position 417 of SEQ ID NO:2 is any amino acid except alanine: or a complement thereof; b) an isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1, wherein the nucleic acid molecule comprises one or more nucleic acid modifications as compared to the nucleotide sequence set forth in SEQ ID NO:1 such that either (i) nucleotide residues 323–325 of SEQ ID NO:1 encode any amino acid except proline; (ii) nucleotide residues 1337–1339 of SEQ ID NO:1 encode any amino acid except glycine or (iii) nucleotide residues 1349–1351 of SEQ ID NO:1 encode any amino acid except alanine; or a complement thereof; and c) an isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1, wherein the nucleic acid molecule comprises one or more nucleic acid modifications either (i) at nucleotide residues 323–325 of SEQ ID NO:1 such that nucleotide residues 323–325 of SEQ ID NO:1 encode any amino acid except proline; (ii) at nucleotide residues 1337–1339 of SEQ ID NO:1 such that nucleotide residues 1337–1339 of SEQ ID NO:1 encode any amino acid except glycine or (iii) at nucleotide residues 1349–1351 of SEQ ID NO:1 such that nucleotide residues 1349–1351 of SEQ ID NO: 1 encode any amino acid except alanine: or a complement thereof.