Patent ID: 7427606

Claim:
A therapeutic method for treating inflammation caused by an immune response to transplanted tissue, comprising the administration to a patient in need thereof an effective amount of an A 2A adenosine receptor agonist, wherein the A 2A adenosine receptor agonist is a compound of formula (I): wherein Z is CR 3 R 4 R 5 ; each R 1 is hydrogen; each R 2 is hydrogen; R 3 is hydrogen; R 4 and R 5 together with the atom to which they are attached form a saturated mono- or bicyclic cycloalkyl ring having 3, 4, 5, 6, 7, 8, 9 or 10 ring atoms wherein the cycloalkyl optionally comprises 1-2 N, O, or S; wherein any ring comprising R 4 and R 5 is substituted with from 1 to 3 R 6 groups; wherein each R 6 is independently (C 1 -C 6 )alkyl, CH 2 OH, —CO 2 R a ,R a C(═O)O—, or R b R c NC(═O)—; wherein any of the alkyl groups of R 6 is optionally substituted on carbon with a substituent selected from the group consisting of CH 2 OH, —CO 2 R a ,R a C(═O)O—, and R b R c NC(═O)—; each R 7 is independently hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, phenyl or phenyl(C 1 -C 3 )alkylene; X is —CH 2 OH, —CO 2 R a , —OC(O)R a , —CH 2 OC(O)R a , or—C(O)NR b R c ; each R a , R b and R c is independently hydrogen, (C 1 -C 6 )alkyl, or (C 1 -C 6 )alkyl substituted with 1-3 (C 1 -C 6 )alkoxy, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkylthio, aryl or aryl (C 1 -C 6 )alkylene; and m is 0 to 6; or a pharmaceutically acceptable salt thereof.