Patent ID: 7279485

Claim:
A compound having the structure wherein D is —CH═ or C═O or (CH 2 ) m where m is 0, 1, 2 or 3; n=0, 1 or 2; A is (CH 2 ) x where x is 1 to 5; or A is (CH 2 ) x 1 , where x 1 is 1 to 5, with an alkenyl bond or an alkynyl bond embedded anywhere in the chain; or A is —(CH 2 ) x 2 —O—(CH 2 ) x 3 — where x 2 is 0 to 5 and x 3 is 0 to 5, provided that at least one of x 2 and x 3 is other than 0; B is a bond or is (CH 2 ) x 4 where x 4 is 1 to 5; R 1 is H or alkyl; R 2 is H, alkyl, alkoxy, halogen, amino or substituted amino; R 2a , R 2b and R 2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R 3 is selected from H, arylalkyl, aryloxycarbonyl, alkyloxycarbonyl, alkynyloxycarbonyl, alkenyloxycarbonyl, alkylcarbonyl, aryl, heteroaryl, heteroaryloxycarbonyl, cycloheteroalkyloxycarbonyl, substituted aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxyaryloxycarbonyl, arylalkyloxycarbonyl, alkylaryloxycarbonyl, arylalkylarylalkyl, aryloxyarylalkyl, haloalkoxyaryloxycarbonyl, alkoxycarbonylaryloxycarbonyl, aryloxyaryloxycarbonyl, arylalkenyloxycarbonyl, heteroaryloxyarylalkyl, alkylsulfonyl, alkenylsulfonyl, aryloxyarylalkyloxycarbonyl, arylalkylcarbonyl, aryloxyalkyloxycarbonyl, arylalkylsulfonyl, arylalkenylsulfonyl, heteroarylsulfonyl, arylsulfonyl, alkoxyarylalkyl, heteroarylalkoxycarbonyl, arylheteroarylalkyl, heteroarylalkyloxyarylalkyl, arylarylalkyl, arylalkenylarylalkyl, arylalkoxyarylalkyl, arylcarbonylarylalkyl, alkylaryloxyarylalkyl, heteroarylarylalkyl, heteroaryloxyarylalkyl, arylaminoarylalkyl, or aminocarbonylarylarylalkyl; (CH 2 ) x , (CH 2 ) x 1 , (CH 2 ) x 2 , (CH 2 ) x 3 , (CH 2 ) x 4 , (CH 2 ) m , and (CH 2 ) n may be optionally substituted; Y is CO 2 R 4 where R 4 is H or alkyl, or Y is a C-linked 1-tetrazole, a phosphinic acid of the structure P(O)(OR 4a )R 5 where R 4a is H, R 5 is alkyl or aryl, or a phosphonic acid of the structure P(O)(OR 4a ) 2 ; including all stereoisomers thereof, prodrug esters thereof, and pharmaceutically acceptable salts thereof.