Patent ID: 7365067

Claim:
A compound represented by the general formula (I) wherein, R 1 and R 2 may be the same or different and each represents an aryl group, heteroaryl group, aryl group substituted with 1 to 3 groups selected from Substituent group α, or heteroaryl group substituted with 1 to 3 groups selected from Substituent group α; R 3 represents any one of the following groups: —CO—R 4 , —CO—O—R 4 , —CO—NH—R 4 , —CO—CH 2 —N(R a )R b , —(CH 2 ) m —CO—R 5 , —(CH 2 ) m —R 5 , —CO—NH—CO—N(R a )R b , —CO—NH—SO 2 —N(R a )R b , —CO—NH—CO—(CH 2 ) m —N(R a )R b , and —CO—NH 2 ; R 4 represents a lower alkyl group, cycloalkyl group, cycloalkyl group substituted with 1 to 3 groups selected from Substituent group α, lower alkenyl group, lower alkynyl group, halogeno lower alkyl group, hydroxy lower alkyl group, lower alkoxyalkyl group, lower aliphatic acyloxyalkyl group or lower alkoxycarbonylalkyl group; R 5 represents a hydroxyl group, a group —OR 4 , or a group —N(R a )R b ; R a and R b may be the same or different and each represents a hydrogen atom, hydroxyl group, lower alkoxy group, hydroxy lower alkoxy group, hydroxy lower alkoxyalkyl group, lower alkoxy lower alkoxyalkyl group, cyano lower alkyl group, cyano lower alkoxyalkyl group, carboxy lower alkyl group, carboxy lower alkoxyalkyl group, lower alkoxycarbonyl lower alkoxyalkyl group, carbamoyl lower alkyl group, carbamoyl lower alkoxyalkyl group, lower aliphatic acylamino lower alkyl group, lower aliphatic acylamino lower alkoxyalkyl group, lower alkylsulfonylamino lower alkyl group, lower alkylsulfonylamino lower alkoxyalkyl group, (N-hydroxy-N-methylcarbamoyl) lower alkyl group, (N-hydroxy-N-methylcarbamoyl) lower alkoxyalkyl group, (N-lower alkoxy-N-methylcarbamoyl) lower alkyl group, (N-lower alkoxy-N-methylcarbamoyl) lower alkoxyalkyl group or R 4 , or together, including the nitrogen atom to which they are attached, represent a nitrogen-containing heterocyclic group or nitrogen-containing heterocyclic group substituted with 1 to 3 groups selected from Substituent group α; m represents an integer of 1 to 6; A represents a methylene group, carbonyl group or sulfonyl group; B represents a single bond, C 1 -C 4 alkylene group or C 2 -C 4 alkenylene group; D represents an oxygen atom or methylene group; E represents a C 1 -C 4 alkylene group or C 2 -C 4 alkenylene group; n represents an integer of 1 to 3; and, Substituent group a represents a group of substituents consisting of halogen atoms, lower alkyl groups, hydroxy lower alkyl groups, halogeno lower alkyl groups, carboxy lower alkyl groups, lower alkoxy groups, hydroxy lower alkoxy groups, hydroxy lower alkoxyalkyl groups, lower alkoxy carbonyl groups, carboxyl groups, hydroxyl groups, lower aliphatic acyl groups, lower aliphatic acylamino groups, (N-hydroxy-N-methylcarbamoyl) lower alkyl groups, (N-lower alkoxy-N-methylcarbamoyl) lower alkyl groups, hydroxy lower aliphatic acylamino groups, amino groups, carbamoyl groups and cyano groups, or a pharmacologically acceptable salt thereof.