Patent ID: 8703178

Claim:
A transdermal device for the administration of bisoprolol, the transdermal device comprising: a backing; and a pressure-sensitive adhesive layer laminated on one side of the backing, the pressure-sensitive adhesive layer comprising: bisoprolol free base, wherein the concentration of bisoprolol free base is 0.5% to 5% by weight of the pressure-sensitive adhesive layer; at least two species of pressure-sensitive adhesive, wherein the first species of pressure-sensitive adhesive is a first polyisobutylene having a viscosity average molecular weight of from 2,000,000 to 5,000,000, wherein the second species of pressure-sensitive adhesive is a second polyisobutylene having a viscosity average molecular weight of from 45,000 to 65,000, wherein the proportion of first polyisobutylene to second polyisobutylene in the pressure-sensitive adhesive layer is in the ratio range of from 1:0.3 to 1:2 by weight, and wherein all the species of pressure-sensitive adhesive in the pressure-sensitive adhesive layer are polyisobutylenes and the total concentration of polyisobutylenes in the pressure-sensitive adhesive layer is 15% to 55% by weight of the pressure-sensitive adhesive layer; isopropyl myristate, wherein the concentration of isopropyl myristate is 20% to 40% by weight of the pressure-sensitive adhesive layer; and tackifier, wherein the concentration of tackifier is 20% to 50% by weight of the pressure-sensitive adhesive layer; and wherein the thickness of the pressure-sensitive adhesive layer is 60 μm to 250 μm; wherein the amount of bisoprolol free base per unit area of the pressure-sensitive adhesive layer is from 0.1 to 0.5 mg/cm 2 ; and wherein the release rate of bisoprolol free base from the pressure-sensitive adhesive layer does not exceed 20 μg/cm 2 /hr during the 24-hour time period immediately following initial application of the transdermal device to the skin.