Patent ID: 7947834

Claim:
A compound of formula (I): wherein: X is NR 2a , NR 2b , NR 2c or NR 2d ; R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 2c and R 2d are, independently, hydrogen, halogen, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, hydroxyl, hydroxy(C 1 -C 5 )alkyl, cyano, —COOR 5 , —NR 6 R 7 , R 5 OOC—(C 1 -C 5 )alkyl, R 6 R 7 N—(C 1 -C 5 )alkyl, —CONR 6 R 7 , R 6 R 7 NCO—(C 1 -C 5 )alkyl, —SO 2 NR 6 R 7 , —COR 5 , aryl, heteroaryl, aryl(C 1 -C 5 )alkyl, heteroaryl(C 1 -C 5 )alkyl or heterocycloalkyl(C 1 -C 5 )alkyl, wherein the aryl or heteroaryl moiety is optionally substituted by 1 to 3 times by cyano, COOR 5 , CONR 6 R 7 , SO 2 R 5 , (C 1 -C 5 )alkoxy, OCH 2 CONR 6 R 7 , halogen, or (C 1 -C 5 )haloalkyl, and when one or more of R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 2c and R 2d are aryl(C 1 -C 5 )alkyl, then one of the aryl(C 1 -C 5 )alkyl is additionally optionally substituted by heteroaryl; R 3a and R 3b are, independently, hydrogen, fluorine, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, alkoxy(C 1 -C 5 )alkyl, hydroxyl, hydroxy(C 1 -C 5 )alkyl, (C 1 -C 5 )haloalkyl, cyano, —COOR 5 , —NR 6 R 7 , R 5 OOC—(C 1 -C 5 )alkyl, R 6 R 7 N—(C 1 -C 5 )alkyl, —CONR 6 R 7 or R 6 R 7 NCO—(C 1 -C 5 )alkyl; R 4 is (C 1 -C 5 )alkyl, (C 3 -C 6 )cycloalkyl, heterocycloalkyl, mono- or bicyclic aryl having from 5 to 10 carbon atoms, or mono- or bicyclic heteroaryl having from 2 to 9 carbon atoms, wherein when R 4 is aryl, heteroaryl or heterocycloalkyl, it is optionally substituted by 1 to 4 times by halogen, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, hydroxyl, hydroxy(C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy(C 1 -C 5 )alkyl, cyano, optionally substituted phenyl, optionally substituted benzyl, —COOR 5 , —NR 6 R 7 , R 5 OOC—(C 1 -C 5 )alkyl, R 6 R 7 N—(C 1 -C 5 )alkyl, —CONR 6 R 7 or —SO 2 NR 6 R 7 , or when two of R 3a , R 3b and R 4 are carried by the same carbon atom, they can form together with the carbon atom to which they are attached a spiro ring of formula a), b), c) or d): wherein: is a single bond or a double bond; s is 0, 1, 2 or 3, t is 0, 1, 2 or 3, provided that s and t are not 0 at the same time; R 8 is hydrogen, halogen, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, trifluoromethyl, hydroxyl, hydroxymethyl, cyano, —COOR 5 , or —NR 6 R 7 ; R 9 is hydrogen, (C 1 -C 5 )alkyl or hydroxyl; Y is a bond, carbon or nitrogen; n is 0 or 1; o, p, q and r are, independently, 0, 1 or 2; i and j are 0, 1, 2, 3 or 4; R 5 is hydrogen, (C 1 -C 5 )alkyl, (C 3 -C 6 )cycloalkyl, or halo(C 1 -C 5 )alkyl; and R 6 and R 7 are, independently, hydrogen, (C 1 -C 5 )alkyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 5 )alkylcarbonyl, hydroxymethyl(C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxymethyl(C 1 -C 5 )alkyl, aryl, optionally substituted heterocycloalkyl, or —SO 2 R 5 , or R 6 and R 7 , taken together with the nitrogen atom to which they are attached, form an optionally substituted heterocycloalkyl; or a pharmaceutically acceptable acid addition salt thereof.