Patent ID: RE40987

Claim:
Synthesised cyclosporin having the formula: wherein: X is -MeBmt or 6,7-dihydro-MeBmt- U is -Abu, Nva, Val or Thr Y is Sar or (D)-MeSer or (D)-MeAla or (D)-MeSer (OAcyl) Z is (N-R)aa where aa={Val, Ile, Thr, Phe, Tyr, Thr (OAc), Thr (OG 1 ), Phe (G 2 ), PheCH 2 (G 3 ) or Tyr (OG 3 )} with R={alkyl>CH 3 }; G 1 ={phenyl-COOH, phenyl-COOMe or phenyl-COOEt}; G 2 ={CH 2 COOH, CH 2 COOMe(Et), CH 2 PO(OMe) 2 or CH 2 PO(OH) 2 }; G 3 ={PO(OH) 2 , PO(OCH 2 CH═CH 2 ) 2 , CH 2 COOH, CH 2 COOMe, or CH 2 COOEt}