Patent ID: 7728031

Claim:
A compound of the formula: or a pharmaceutically acceptable salt, ester, amide, or radiolabelled form thereof, wherein: R 1 is alkyl, C 3 -C 5 cycloalkyl, or (C 3 -C 5 cycloalkyl)methyl; R 2a , R 2b , R 2c , R 2d , R 2e , and R 2f each are independently hydrogen, methyl, or fluoromethyl; R 3a , R 3b , R 3c , and R 3d are each independently hydrogen, alkyl, fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile, with the proviso that when one or more of R 3a , R 3b , R 3c , and R 3d are alkyl, then at least one of R 3a , R 3b , R 3c , and R 3d is fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile; L 1 is a bond, oxygen, sulfur, carbonyl, alkylene, alkylcarbonyl, alkylamino, —C(═N—Oalkyl)-, or NR 4 , L 2 is a bond, oxygen, sulfur, carbonyl, alkylene, alkylcarbonyl, alkylamino, —C(═N—Oalkyl)-, NR 5 , —C(═O)NR 5 —, or —NR 5 C(═O)—, Cy 1 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; Cy 2 is aryl, cycloalkyl, cycloalkenyl, heteroaryl or heterocycle, wherein the heteroaryl or heterocycle moiety has 1, 2, or 3 heteroatoms selected from nitrogen, oxygen, and sulfur, provided that at least one heteroatom is nitrogen; and R 4 and R 5 at each occurrence is hydrogen or alkyl; provided that Cy 2 is not