Patent ID: 8846637

Claim:
A bicyclic nucleoside having Formula I: wherein: Bx is a heterocyclic base moiety; one of T 1 and T 2 is H or a hydroxyl protecting group and the other of T 1 and T 2 is H, a hydroxyl protecting group or a reactive phosphorus group; Q 1 and Q 2 are each independently, H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl; G 1 and G 2 are each independently, H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, substituted C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or substituted C 2 -C 6 alkynyl; Z is S or NR; R is H, C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl or substituted acyl; each substituted group is, independently, mono or poly substituted with substituent groups independently selected from halogen, OJ 1 , SJ 1 , NJ 1 J 2 , N 3 , CN, C(═O)OJ 1 , C(═O)NJ 1 J 2 , C(═O)J 1 , O—C(═O)NJ 1 J 2 , N(H)C(═O)NJ 1 J 2 and N(H)C(═S)NJ 1 J 2 ; each J 1 and J 2 is, independently, H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 aminoalkyl or a protecting group; and wherein at least one of Q 1 , Q 2 , G 1 and G 2 is other than H.