Patent ID: 7151097

Claim:
A compound having the Formula (I) wherein A is nitrogen and B is carbon, or A is carbon and B is nitrogen; R 0 is an aryl optionally substituted with one or more substituents, or a heteroaryl optionally substituted with one or more substituents; R 1 is aryl optionally substituted with one or more substituents, heteroaryl optionally substituted with one or more substituents, —CH═CH—R 1a , or —CH 2 CH 2 —R 1a , where R 1a is hydrogen or a chemical moiety selected from (C 1 –C 8 )alkyl, 3- to 8-membered partially or fully saturated carbocyclic ring(s), 3- to 6-membered partially or fully saturated heterocycle, aryl, or heteroaryl, where the chemical moiety is optionally substituted with one or more substituents; X is O, S, SO, SO 2 , —N(R 2a )— or —C(R 2b )(R 2c )—, where R 2a , R 2b and R 2c are each independently hydrogen, (C 1 –C 4 )alkyl, halo-substituted (C 1 –C 4 )alkyl, or (C 1 –C 5 )acyl; R 3a and R 3b are each independently hydrogen, (C 1 –C 6 )alkyl, or halo-substituted (C 1 –C 6 )alkyl, or either R 3a or R 3b taken together with R 4 forms a fully or partially saturated 5- to 6-membered heterocyclic ring, where the heterocyclic ring optionally contains an additional heteroatom selected from oxygen, nitrogen or sulfur and is optionally substituted with one or more substituents; and R 4 is a chemical moiety selected from the group consisting of (C 1 –C 8 )alkyl, aryl, heteroaryl, aryl(C 1 –C 4 )alkyl, a 3- to 8-membered partially or fully saturated carbocyclic ring(s), heteroaryl(C 1 –C 3 )alkyl, 5–6 membered lactone, 5- to 6-membered lactam, and a 3- to 8-membered partially or fully saturated heterocycle, where said chemical moiety is optionally substituted with one or more substituents, or R 4 taken together with either R 3a or R 3b forms a fully or partially saturated 5- to 6-membered heterocyclic ring, where the heterocyclic ring optionally contains an additional heteroatom selected from oxygen, nitrogen or sulfur and is optionally substituted with one or more substituents; a pharmaceutically acceptable salt thereof or a solvate or hydrate of said compound, or said salt.