Patent ID: 8841413

Claim:
An isolated peptidomimetic having a sequence of Formula (I), or a tautomer or solvate thereof; A-Z 1 —Z 2 —Z 3 —Z 4 —Z 5 —Z 6 —Z 7 —Z 8 —Z 9 —Z 10 —Z 11 —B (I) wherein, A represents the groups —NH—R 1 , R 3 —CO— or R 3 —SO 2 —, wherein R 1 represents hydrogen, or optionally substituted linear or branched (C 1 -C 10 ) alkyl chain; R 3 is selected from linear or branched (C 1 -C 10 ) alkyl, (C 3 -C 6 ) cycloalkyl, aryl, heteroaryl or arylalkyl groups; B represents the groups —COOR 2 , —CONHR 2 or CH 2 OR 2 or a tetrazole, wherein R 2 represents H, optionally substituted groups selected from linear or branched (C 1 -C 10 ) alkyl, aryl or aralkyl groups; Z 1 represents Histidine; Z 2 represents a naturally or unnaturally occurring amino acid selected from the group comprising L-Serine, D-Serine, L-alanine, D-alanine, α-amino-isobutyric acid, and 1-amino cyclopropane carboxyl acid; Z 3 represents glutamine (Gln; Q) or compounds of formula II; Z 4 represents glycine or the group 1-amino cyclopropane carboxylic acid; Z 3 represents a naturally or non-naturally occurring amino acid comprising a hydroxyl side chain; Z 6 represents, a naturally of unnaturally occurring amino acid having a disubstituted alpha carbon having two side chains, wherein each of them are independently selected from an optionally substituted alkyl, aryl or an aralkyl group wherein the substituents are selected from one or more alkyl groups or one or more halo groups; Z 7 and Z 8 independently represents a naturally or non-naturally occurring amino acid comprising a hydroxyl side chain; Z 9 independently represents a naturally or non-naturally occurring amino acid having an amino acid side chain comprising an acidic group; Z 10 represents a naturally or unnaturally occurring amino acid of formula IV and Z 11 represents a naturally or unnaturally occurring amino acid of formula V(a-d)