Patent ID: 7541372

Claim:
An isoxazol-4-yl-oxadiazole derivative of formula I wherein R 1 is hydrogen, halogen, aryl, heterocyclyl, heteroaryl, cyano, lower alkyl, —(CH 2 ) n -cycloalkyl, —(CH 2 ) n —N(R) 2 , —(CH 2 ) n —O-lower alkyl or —(CH 2 ) n —OH; wherein heterocyclyl is selected from the group consisting of piperidine, piperazine, morpholine, pyrrolidin, pyrrolidin-2-one, imidazolidin-2-one, tetrahydrofuran, thiomorpholine, thiomorpholine-1-oxide, thiomorpholinel-1,1-dioxide, 1-H-benzoimidazole, 1,3-dihvdro-benzolimidazole-2-one, tetrahydro-pyrane, and 1,3-dimethyl-1,3-dihydro-benzoimidazol-2-one; and wherein heteroaryl is selected from the group consisting of quinolyl, indolyl, pyridinyl, triazolyl, benzotriazolyl, isoxazolyl, furanyl, thiophenyl, benzoimidazolyl, dihydrobenzimidazolyl-2-one, imidazolyl, oxazolyl, oxadiazolyl and pyrazinyl; n is 0, 1 or 2 R is hydrogen or lower alkyl; R 2 is cycloalkyl, aryl, each of which is optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen, lower alkyl substituted by halogen, C(O)O-lower alkyl, lower alkylsulfonyl, —NR a R b , —C(O)—NR a R b , —C(O)-heterocyclyl, benzyloxy, heterocyclyl optionally substituted by hydroxy, halogen or lower alkyl, and heteroaryl optionally substituted by lower alkyl; R a and R b are each independently hydrogen, lower alkylsulfonyl, —C(O)H, —(CH 2 ) n —N(R) 2 , —(CH 2 ) n —O-lower alkyl, —(CH 2 ) n —S-lower alkyl, —(CH 2 ) n —S(O) 2 -lower alkyl, heteroarylsulfonyl, lower alkyl, —(CH 2 ) n -heterocyclyl optionally substituted by lower alkyl, or is —(CH 2 ) n -cycloalkyl, —(CH 2 ) n -heteroaryl, —(CH 2 ) n —OH, or —(CO)—R′ , wherein R′ is lower alkyl, cycloalkyl or heteroaryl; R 3 is aryl or heteroaryl, each of which is optionally substituted by halogen or lower alkyl substituted by halogen; or a pharmaceutically acceptable acid addition salt thereof.