Patent ID: 7354923

Claim:
A compound having the structure: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein R 1 is -L 1 -J or, if X is CH 2 , is H or -L 1 -J; R 2 is (CH 2 ) y â€”W or, if X is CH 2 , is H or -L 1 -J, on the proviso that R 1 and R 2 are not both H; R 3 is -L 2 -Q; L 1 is a linker selected from the group consisting of â€”(CH 2 ) y â€”, â€”Oâ€”(CH 2 ) y â€”, â€”Oâ€”, â€”NHâ€”(CH 2 ) y â€”, â€”(Câ•O)(CH 2 ) y â€”, â€”(Câ•O)â€”Oâ€”(CH 2 ) y â€”, and â€”CH 2 (Câ•O)NH;â€”: J is a ring structure selected from the group consisting of substituted or unsubstituted aromatic carbocyclic rings, substituted or unsubstituted non-aromatic carbocyclic rings, substituted or unsubstituted aromatic fused carbobicyclic ring groups, substituted or unsubstituted aromatic carbocyclic ring groups wherein the rings are joined by a bond or â€”Oâ€”, and substituted or unsubstituted aromatic fused heterobicyclic ring groups; wherein in each instance each ring in the ring structure consists of 5 or 6 ring atoms; W is selected from the group consisting of NH 2 , NH(Câ•NH)NH 2 , â€”NHCOCH 3 , â€”CONHCH 3 , â€”NH(Câ•NH)NHMe, â€”NH(Câ•NH)NHEt, â€”NH(Câ•NH)NHPr, â€”NH(Câ•NH)NHPrâ€”I, â€”NH(Câ•NH)NH 2 , â€”NH(Câ•O)OCH 3 , â€”NH(Câ•O)CH 3 , â€”-NH(Câ•O)NH 2 , â€”NH(Câ•O)NHCH 3 , L 2 is a linker selected from the group consisting of Q is an aromatic carbocyclic ring selected from the group consisting of phenyl, substituted phenyl, naphthyl and substituted naphthyl; R 4 is H, â€”R 5 or â€”R 5 â€”R 6 ; R 5 is an amino acid residue or an amine capping group, provided that if R 6 is present, R 5 is an amino acid residue; R 6 is H or an amine capping group; X is CH 2 or Câ•O; and y is at each occurrence independently from 1 to 6.