Patent ID: 8450291

Claim:
A method of inhibiting the expression of PIK3CA in a cell, comprising contacting said cell with an effective amount of an oligomer, wherein the oligomer has the formula: 5′ A s G s Me C s c s a s t s t s c s a s t s t s c s c s A s Me C s Me C-3′ (SEQ ID NO: 67); or 5′-T s T s A s t s t s g s t s g s c s a s t s c s t s Me C s A s G-3′ (SEQ ID NO: 77), wherein uppercase letters denote beta-D-oxy-LNA monomers and lowercase letters denote DNA monomers, the subscript “s” denotes a phosphorothioate linkage, and Me C denotes a beta-D-oxy-LNA monomer containing a 5-methyl cytosine base.