Patent ID: 8273754

Claim:
A compound having the formula Ia: or a salt thereof, wherein: R n4 is H, or unsubstituted or substituted C 1 -C 6 alkyl; R q1 is H, or unsubstituted or substituted C 1 -C 6 alkyl; R q2 is H, or unsubstituted or substituted C 1 -C 6 alkyl, or R q1 and R q2 , together with the atoms they attach to, form a 5- or 6-membered ring, wherein said ring is optionally unsaturated and optionally contains from 1 to 4 heteroatoms selected form N, O and S, and is optionally substituted; Z is —(CH 2 ) m —, —C(O)—, —C(O)C(O)—, —C(O)O—, —C(O)NR 1 —, —S(O) 2 —, —S(O) 2 NR 1 — or a bond; R 1 is H, or unsubstituted or substituted C 1 -C 6 alkyl; R is unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 1 -C 6 alkoxy, unsubstituted or substituted C 6 -C 10 aryloxy, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, —C(O)R 2 , —C(O)OR 2 , —C(O)NR 2 R 2 ′, —NR 2 R 2 ′, —NR 2 ′C(O)R 2 , or —NR 2 ′C(O)OR 2 ; R 2 and R 2 ′ are each independently H, unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 6 -C 10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C 3 -C 10 carbocycle, or unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S; m is 0, 1, 2, 3, or 4; and w is 1.