Patent ID: 7683065

Claim:
A compound of formula IA-ii, formula IB-ii formula IC-ii, or formula ID-ii: or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 , taken together with the nitrogen atom to which they are bound, form an optionally substituted 3-8-membered, monocyclic saturated or partially unsaturated ring having 0-3 additional heteroatoms independently selected from nitrogen, sulfur, or oxygen; wherein the ring formed by R 1 and R 2 taken together, are each optionally and independently substituted at one or more substitutable carbon, nitrogen, or sulfur atoms with z independent occurrences of —R 4 , wherein z is 0-5; y is 0-5; each occurrence of R 3b , R 3c , R 4 , and R 5 is independently Q—R X ; wherein Q is a bond or is a C 1 -C 6 alkylidene chain wherein up to two non-adjacent methylene units of Q are optionally and independently replaced by —NR—, —S—, —O—, —CS—, —CO 2 —, —OCO—, —CO—, —COCO—, —CONR—, —NRCO—, —NRCO 2 —, —SO 2 NR—, —NRSO 2 —, —CONRNR—, —NRCONR—, —OCONR—, —NRNR—, —NRSO 2 NR—, —SO—, —SO 2 —, —PO—, —PO 2 —, —OP(O)(OR)—, or —POR—; and each occurrence of R X is independently selected from —R′, halogen, —NO 2 , —CN, —OR′, —SR′, —N(R′) 2 , —NR′COR′, —NR′CON(R′) 2 , —NR′CO 2 R′, —COR′, —CO 2 R′, —OCOR′, —CON(R′) 2 , —OCON(R′) 2 , —SOR′, —SO 2 R′, —SO 2 N(R′) 2 , —NR′SO 2 R′, —NR′SO 2 N(R′) 2 , —COCOR′, —COCH 2 COR′, —OP(O)(OR′) 2 , P(O)(OR′) 2 , —OP(O) 2 OR′, —P(O) 2 OR′, —PO(R′) 2 , or OPO(R′) 2 ; each occurrence of R is independently hydrogen or an optionally substituted C 1-6 aliphatic group; each occurrence of R′ is independently hydrogen or an optionally substituted C 1-6 aliphatic group, provided that: iii) in formula I-B, when y is 0, R3a and R3b are both hydrogen, R1 and R2 taken together form 4-hydroxy-2-hydroxymethyl-pyrrolidin-1-yl, then R 3C is not —NRCO—R X or —NRCOR′.