Patent ID: 8558023

Claim:
A process for preparing an enantiomerically enriched cycloalkylene-substituted alanine compound having the structure: comprising the step of asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand wherein: n is 1, 2, 3, or 4, R is selected from the group consisting of hydrogen, alkyl, aryl and —COR 4 , R 1 is selected from the group consisting of hydrogen, halogen, alkyl, aryl, alkoxy, aryloxy and —COOR 4 , and R 2 is selected from the group consisting of hydrogen, alkyl and aryl groups, wherein each R 4 is independently selected from the group consisting of alkyl and aryl groups; to prepare enantiomerically enriched cycloalkyene substituted alanine compounds having the structure of Formula (IA) or (IB):