Patent ID: 7033583

Claim:
A prodrug compound comprising the formula: (I) R 1 -E that releases an —SH-containing biologically active moiety wherein: R 1 is a straight or branched residue of a water soluble polymer; wherein: D 1 is a residue of an —SH-containing biologically active moiety bonded through the sulfur; (AA) is an amino acid residue; E 2 and E 3 are independently H, E 1 or Y 1 , Y 2 and Y 3 are independently O, S or NR 7 ; X 1 and X 2 are independently OH or E; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are independently selected from the group consisting of H, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; n is zero or a positive integer; and p is zero or a positive integer.