Patent ID: 7538102

Claim:
A compound of formula I wherein: R 1 is CO 2 R 5 or CONR 6 R 7 ; R 2 is cycloalkoxy or bridged [2.1.1], [2.2.1], [2.2.2], [3.1.1], or [3.2.1] bicycloalkoxy, where the cycloalkyl or bridged bicycloalkyl moiety is substituted with 0-3 alkyl substituents; or R 2 is N(R 8 )(R 9 ); or R 2 is pyrrolidinyl, piperidinyl, piperazinyl, N-alkylpiperazinyl, N-(BOC)piperazinyl, N-benzylmethylpiperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl, and is substituted with 1 substituent selected from alkenyl, R 11 , (R 11 )alkyl, (R 11 CO)alkyl, pyrazinyl, pyrimidinyl, and phenyl where phenyl is substituted with 0-2 halo, alkyl, haloalkyl, cyano, hydroxy, alkoxy, haloalkoxy, CONH 2 , CONH(alkyl), or CON(alkyl) 2 substituents; or R 2 is homopiperazinyl or diazepanone, and is substituted with 0-2 substituents selected from the group consisting of halo, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrimidinyloxy, phenyl substituted with 0-2 halo, alkyl, or alkoxy substituents, benzyl, (pyridinyl)methyl, benzyloxycarbonyl, alkylcarbonyl, alkoxycarbonyl, (R 11 )alkyl, and (R 11 CO)alkyl; or R 2 is R 3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy; R 4 is C 5-7 cycloalkyl; R 5 is hydrogen or alkyl; R 6 is hydrogen, alkyl, cycloalkyl, alkoxy, or SO 2 R 10 ; R 7 is hydrogen, alkyl, or cycloalkyl; or NR 6 R 7 taken together is pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl; R 8 is 4-piperidinyl, 4-(N-alkyl)piperidinyl, 3-(N-alkyl)pyrrolidinyl, (R 11 )alkyl, (R 11 CO)alkyl, (amino)cycloalkyl, (alkylamino)cycloalkyl, or (dialkylamino)cycloalkyl; R 9 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, or dialkylaminoalkyl; R 10 is alkyl, haloalkyl, cycloalkyl, phenyl, amino, alkylamino, dialkylamino, benzylamino, or (benzyl)(alkyl)amino; or R 10 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl, and is substituted with 0-2 substituents selected from halo and alkyl; and R 11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, homomorpholinyl, homopiperidinyl, morpholinyl, or thiomorpholinyl, and is substituted with 0-2 substituents selected from halo and alkyl; or a pharmaceutically acceptable salt thereof.