Patent ID: 7812021

Claim:
A compound of formula I wherein Ar is aryl or a five or six membered heteroaryl selected from the group consisting of quinoxalinyl, pyrazinyl, pyrazolyl, pyridinyl, pyridyl, pyrimidinyl, oxadiazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, thiophenyl, isoxazolyl, pyrrolyl, furanyl or imidazolyl; is a six membered mono heterocyclic group, wherein X is a carbon atom, SO 2 or a further hetero atom, selected from the group consisting of N and O; if X is a carbon atom, O, SO 2 or unsubstituted N, then R 1 is hydrogen, hydroxy, cyano, —(CH 2 ) q —OH, —(CH 2 ) q —NRR′, —(CH 2 )q-CN, lower alkyl, —S(O) 2 -lower alkyl, —NR—S(O) 2 -lower alkyl, —C(O)-lower alkyl, —NR—C(O)-lower alkyl, phenyl, or a piperidinyl-2-one; if X is a N-atom, substituted by R 1 , then R 1 is hydrogen, —(CH 2 ) q —OH, —(CH 2 ) q —NRR′, —(CH 2 )q-CN, lower alkyl, —S(O) 2 -lower alkyl, aryl, or a five or six membered heteroaryl or —C(O)-lower alkyl provided that q is 2 or 3; R and R′ are each independently hydrogen or lower alkyl; R 2 is hydrogen, halogen, lower alkyl, cyano, lower alkoxy substituted by halogen, lower alkyl substituted by halogen or is a five or six membered heteroaryl; R 3 is hydrogen or halogen; R 4 is hydrogen or lower alkyl; n is 1 or 2; in case n is 2, R 1 may be the same or different; o is 1 or 2; in case o is 2, R 2 may be the same or different; p is 1 or 2; in case p is 2, R 3 may be the same or different; q is 1, 2 or 3; and s is 0, 1, 2, 3 or 4 wherein (C) s is additionally bonded to hydrogen atoms; or a pharmaceutically active salt thereof, including all stereoisomeric forms, individual diastereoisomers and enantiomers of the compound of formula (I) as well as racemic and non-racemic mixtures thereof.