Patent ID: 8846913

Claim:
A compound of formula 1: where R 1 is selected from the group consisting of —OR 7 and —NR 8 R 9 ; R 2a is selected from the group consisting of —OH, —OP(O)(OH) 2 , and —OC(O)CH(R 37 )NH 2 , and R 2b is —CH 3 ; or R 2a and R 2b are taken together to form —CH 2 —CH 2 —; or R 2a is taken together with R 7 to form —OCR 18 R 19 — or is taken together with R 8 to form —OC(O)—; Z is selected from the group consisting of —CH— and —N—; a is 0 or 1; R 5 is selected from the group consisting of halo, —CH 3 , —CF 3 , and —CN; b is 0 or an integer from 1 to 3; each R 6 is independently selected from the group consisting of halo, —OH, —CH 3 , —OCH 3 , and —CF 3 ; R 7 is selected from the group consisting of H; —C 1-8 alkyl; —C 1-3 alkylene-C 6-10 aryl; —C 1-3 alkylene-C 1-9 heteroaryl; —C 3-7 cycloalkyl; —[(CH 2 ) 2 O] 1-3 CH 3 ; —C 1-6 alkylene-OC(O)R 10 ; —C 1-6 alkylene-NR 12 R 13 ; —C 1-6 alkylene-C(O)R 31 ; —C 0-6 alkylenemorpholinyl; —C 1-6 alkylene-SO 2 —C 1-6 alkyl; R 10 is selected from the group consisting of —C 1-6 alkyl, —O—C 1-6 alkyl, —C 3-7 cycloalkyl, —O—C 3-7 cycloalkyl, phenyl, —O-phenyl, —NR 12 R 13 , —CH[CH(CH 3 ) 2 ]—NH 2 , —CH[CH(CH 3 ) 2 ]—NHC(O)O—C 1-6 alkyl, and —CH(NH 2 )CH 2 COOCH 3 ; and R 12 and R 13 are independently selected from the group consisting of H, —C 1-6 alkyl, and benzyl, or R 12 and R 13 are taken together as —(CH 2 ) 3-6 —, —C(O)—(CH 2 ) 3 —, or —(CH 2 ) 2 O(CH 2 ) 2 —; R 31 is selected from the group consisting of —O—C 1-6 alkyl, —O-benzyl, and —NR 12 R 13 ; and R 32 is —C 1-6 alkyl or —C 0-6 alkylene-C 6-10 aryl; R 8 is selected from the group consisting of H, —OH, —OC(O)R 14 , —CH 2 COOH, —O-benzyl, pyridyl, and —OC(S)NR 15 R 16 ; R 14 is selected from the group consisting of H, —C 1-6 alkyl, —C 6-10 aryl, —OCH 2 —C 6-10 aryl, —CH 2 O—C 6-10 aryl, and —NR 15 R 16 ; and R 15 and R 16 are independently selected from the group consisting of H and —C 1-4 alkyl; R 9 is selected from the group consisting of H, —C 1-6 alkyl, and —C(O)R 17 ; and R 17 is selected from the group consisting of H, —C 1-6 alkyl, —C 3-7 cycloalkyl, —C 6-10 aryl, and —C 1-9 heteroaryl; R 18 and R 19 are independently selected from the group consisting of H, —C 1-6 alkyl, and —O—C 3-7 cycloalkyl, or R 18 and R 19 are taken together to form ═O; R 37 is selected from the group consisting of H, —CH(CH 3 ) 2 , phenyl, and benzyl; each alkyl group in R 1 is optionally substituted with 1 to 8 fluoro atoms; and; the methylene linker on the biphenyl is optionally substituted with one or two —C 1-6 alkyl groups or cyclopropyl; and P 1 is H or an amino-protecting group selected from the group consisting of t-butoxycarbonyl, trityl, benzyloxycarbonyl, 9-fluorenylmethoxycarbonyl, formyl, trimethylsilyl, and t-butyldimethylsilyl; or a salt thereof.