Patent ID: 8173682

Claim:
A compound, or an enantiomer, stereoisomer, or a tautomer of said compound or a pharmaceutically acceptable salt thereof, with said compound having the structure shown in formula I: wherein R is hydrogen or C 1-6 alkyl; R 1 is C 1-4 alkyl, C 1-4 alkenyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and sum of x and y is 2n+1, wherein said alkyl or alkenyl is optionally substituted with one or more hydroxy or chlorine; R 2 is Ar—Y, wherein Ar is optionally substituted thienyl wherein said substituents are selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkenyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and the sum of x and y is 2n+1, —NO 2 , —CH 2 NH 2 , —NH 2 , —NH(C 1-4 alkyl), —N(C 1-4 alkyl) 2 , —CN, —C(O)R 11 , —NHC(O)(C 1-4 alkyl), —SO 2 Cl, —SO 2 (C 1-4 alkyl), halogen and hydroxy; and Y is —SO 2 NR 5 R 6 , —(CH 2 ) n NR 7 R 8 , and —C(O)NR 7 R 8 ; R 3 is hydrogen, C 1-4 alkyl, C 1-4 alkenyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and the sum of x and y is 2n+1, wherein said alkyl or alkenyl is optionally substituted with one or more hydroxy or chlorine; R 4 is C 1-6 alkyl, C 1-6 alkenyl, C 3-8 cycloalkyl, fluoroalkyl or fluoroalkoxy of the formula C n H x F y or OC n H x F y wherein n is an integer from 1 to 4, x is an integer from 0 to 8, y is an integer from 1 to 9 and the sum of x and y is 2n+1; R 5 and R 6 taken together with the nitrogen atom to which they are attached form an unsubstituted or at least monosubstituted pyrrolidine; or R 7 and R 8 taken together with the nitrogen atom to which they are attached form an unsubstituted or at least monosubstituted pyrrolidine; wherein said substituents are selected from: aryl, oxo, fluorine, chlorine, bromine, —CF 3 , —OCF 3 , —NO 2 , —CN, —C(O)R ii , —NHC(O)(C 1-3 alkyl), —NH 2 , hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —NH(C 1-3 alkyl), —N(C 1-3 alkyl) 2 , —SO 2 NH 2 , —SO 2 (C 1-3 alkyl) and —NH—SO 2 (C 1-3 alkyl), and aryl may optionally be at least monosubstituted with fluorine, chlorine, bromine, hydroxy, C 1-3 alkyl or C 1-3 alkoxy; R 11 is hydroxy, C 1-3 alkoxy, —O-phenyl, —NH 2 , —NH(C 1-3 alkyl), —N(C 1-3 alkyl) 2 or phenyl; n is an integer from 1 to 4; and wherein aryl is a 6 to 10-membered, aromatic mono- or bicyclic ring.