Patent ID: 8492553

Claim:
A compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein u and v are independently 0, 1, 2, or 3; one of A and B is phenyl and the other is pyrimidinyl; each R 1 and R 2 is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, arylalkoxycarbonyl, carboxy, formyl, halo, haloalkyl, hydroxy, hydroxyalkyl, —NR a R b , (NR a R b )alkyl, and (NR a R b )carbonyl; R 3 and R 4 are each independently selected from hydrogen, alkoxycarbonyl, alkyl, arylalkoxycarbonyl, carboxy, haloalkyl, (NR a R b )carbonyl, and trialkylsilylalkoxyalkyl; R 5 and R 6 are each independently selected from hydrogen, alkenyl, alkoxyalkyl, alkyl, haloalkyl, and (NR a R b )alkyl; or, R 5 and R 6 , together with the carbon atom to which they are attached, form a five or six membered saturated ring optionally containing one or two heteroatoms selected from NR z , O, and S; wherein R z is selected from hydrogen and alkyl; R 7 is selected from hydrogen, R 9 —C(O)—, and R 9 —C(S)—; R 8 is selected from hydrogen and alkyl; R 9 is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonylalkyl, aryl, arylalkenyl, arylalkoxy, arylalkyl, aryloxyalkyl, cycloalkyl, (cycloalkyl)alkenyl, (cycloalkyl)alkyl, cycloalkyloxyalkyl, haloalkyl, heterocyclyl, heterocyclylalkenyl, heterocyclylalkoxy, heterocyclylalkyl, heterocyclyloxyalkyl, hydroxyalkyl, —NR c R d , (NR c R d )alkenyl, (NR c R d )alkyl, and (NR c R d )carbonyl; R 10 is selected from wherein R 11 and R 12 are each independently selected from hydrogen, alkenyl, alkoxyalkyl, alkyl, haloalkyl, and (NR a R b )alkyl; or, R 11 and R 12 , together with the carbon atom to which they are attached, form a five or six membered saturated ring optionally containing one or two heteroatoms selected from NR z , O, and S; wherein R z is selected from hydrogen and alkyl; R 13 is selected from hydrogen and alkyl; R 14 is selected from hydrogen, R 15 —C(O)—, and R 15 —C(S)—; R 15 is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonylalkyl, aryl, arylalkenyl, arylalkoxy, arylalkyl, aryloxyalkyl, cycloalkyl, (cycloalkyl)alkenyl, (cycloalkyl)alkyl, cycloalkyloxyalkyl, haloalkyl, heterocyclyl, heterocyclylalkenyl, heterocyclylalkoxy, heterocyclylalkyl, heterocyclyloxyalkyl, hydroxyalkyl, —NR c R d , (NR c R d )alkenyl, (NR c R d )alkyl, and (NR c R d )carbonyl; m is 0, 1, or 2; n is 0, 1, 2, 3, or 4; X is selected from O, S, S(O), SO 2 , CH 2 , CHR 16 , and C(R 16 ) 2 ; provided that when m is 0, X is selected from CH 2 , CHR 16 , and C(R 16 ) 2 ; each R 16 is independently selected from alkoxy, alkyl, aryl, halo, haloalkyl, hydroxy, and —NR a R b , wherein the alkyl can optionally form a fused three- to six-membered ring with an adjacent carbon atom, wherein the three- to six-membered ring is optionally substituted with one or two alkyl groups.