Patent ID: 6852738

Claim:
A compound having the formula I: or a pharmaceutically acceptable salt thereof, wherein X is selected from CH and N; R 1 is —(CH 2 ) a (Y 1 ) b (Z) c (Y 2 ) d R 4 ; a, b, c, and d are each independently 0 or 1, with the proviso that if c is 0, then b and d are not both 1; Y 1 and Y 2 are each independently O or NH; Z is selected from C(O) and S(O) 2 ; R 2 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, Heteroaryl, and Heterocycle, and R 2 is optionally substituted with 1-5 groups R 3 ; Each R 3 is independently selected from H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 Aryl, —OC 1-6 alkyl, —OC 2-6 alkenyl, —OC 2-6 alkynyl, —OC 6-10 Aryl, C 3-6 Cycloalkyl, Heteroaryl, Heterocycle, CN, NO 2 , S(O) m R 4 , SO 2 NHR 4 , SO 2 NR 4 R 4 , CO 2 H, and CONHR 4 , wherein each alkyl, alkenyl, alkynyl, Aryl, -Oalkyl, -Oalkenyl, -Oalkynyl, -Oaryl, Cycloalkyl, Heteroaryl, and Heterocycle is optionally substituted with 1-5 substituents independently selected from halogen, —OCF 3 , —OCH 3 , CF 3 and CH 3 ; Each R 4 is independently selected from the group consisting of H, C 1-10 alkyl, C 3-10 Cycloalkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 6-10 Aryl, Heterocycle, and Heteroaryl, wherein R 4 is optionally substituted with 1-3 groups R 5 ; Each R 5 is independently selected from halogen, C 1-6 alkyl, C 6-10 Aryl, —OC 16 alkyl, —OC 2-6 alkenyl, —OC 2-6 alkynyl, —OC 6-10 Aryl, C 3-6 Cycloalkyl, CN, NO 2 , CO 2 H, CO 2 C 1 -C 6 alkyl and CONH 2 , wherein each alkyl, Aryl, -Oalkyl, -Oalkenyl, -Oalkynyl, -Oaryl, Cycloalkyl and CO 2 alkyl is optionally substituted with 1-5 substituents independently selected from halogen, —OCF 3 , —OCH 3 , CF 3 and CH 3 ; m is 0, 1 or 2; Each alkyl, alkenyl and alkynyl group may be linear or branched; Cycloalkyl is a saturated or partly saturated monocyclic or bicyclic carbocyclic ring system; Aryl is a monocyclic or bicyclic carbocyclic aromatic ring system; Heterocycle is a fully saturated or partially saturated monocyclic or bicyclic ring system comprising at least one heteroatom selected from N, S and O in the ring and comprising 4 to 11 atoms in the ring; and Heteroaryl is a monocyclic or bicyclic aromatic ring system comprising at least one ring heteroatom selected from N, O and S and comprising 4-11 atoms in the ring or rings.