Patent ID: 8097650

Claim:
A method of treating an arrhythmia associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of a TREK-1 agonist effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the arrhythmia, wherein the TREK-1 agonist is a compound of the formula: or a pharmaceutically acceptable ester or salt thereof, wherein: R 2 selected from the group consisting of —C 1 to C 8 alkyl, —C 2 to C 8 alkenyl, —O—(C 1 to C 8 alkyl), —NH(C 1 to C 8 alkyl), wherein each C 1 to C 8 alkyl and C 2 to C 8 alkenyl may be branched or unbranched and may be optionally substituted with one or more substituents selected from the group consisting of halo, lower alkoxy, oxo, CN, NO2, NH2, NH—(lower alkyl), N(lower alkyl)2, cycloalkyl, and aryl; each R3 is independently selected from the group consisting of halo, lower alkyl, lower alkoxy, NH2, NH—(lower alkyl), N(lower alkyl)2, NO2, CN, CF3, and; R4 is selected from the group consisting of H and lower alkyl; and n=0, m=0 to 2, and p=0 to 2.