Patent ID: 8637461

Claim:
A method of diagnosing a risk of oxidative stress-impaired wound healing in a subject by testing for oxidative stress, comprising the steps of: detecting IGF-1 resistance in said subject, wherein detection of IGF-1 resistance indicates an increased risk of oxidative stress-impaired wound healing in said subject, wherein identifying IGF-1 resistance in a subject comprises the steps of: administering to the subject a dose of IGF-1 to modulate said subject's glucose metabolism; comparing said subject's measured glucose metabolism in response to the dose of IGF-1 to a known standard response to a similar dose of IGF-1; if said subject's measured glucose metabolism is below the known standard response to a similar dose of IGF-1, administering to the subject a dose of an antioxidant, wherein the antioxidant is EUK-134; repeating the step of administering to the subject a dose of IGF-1 effective to modulate said subject's glucose metabolism; repeating the step of measuring said subject's glucose metabolism in response to the dose of IGF-1; and comparing said subject's glucose metabolism in response to IGF-1 before administering the antioxidant with said subject's glucose metabolism in response to IGF-1 after administering the antioxidant; wherein a determination that the antioxidant increases said subject's glucose metabolism in response to the dose of IGF-1 indicates that said subject suffers from oxidative stress.