Patent ID: 8748389

Claim:
A peptide comprising an amino acid sequence that is: a) part of the amino acid sequence of CDK4 protein; or b) homologous to part of the amino acid sequence of CDK4 protein; which peptide is cytotoxic to, and/or inhibiting to the growth of, a cancer cell and/or stimulating to the growth of a non-cancerous cell and/or a control cell, and wherein said peptide is non-inhibitory to a non-cancerous cell and/or a control cell, and which peptide comprises n amino acid sequences having the general formula (ZRGXRZ)V (SEQ ID NO:40), wherein R is arginine, G is glycine, Z may be present or absent and at least one Z is present, X and Z are independently proline or threonine and at least one of X and/or Z is proline, V is valine and may be present or absent and n is an integer from 2-10; and m further amino acid sequences, each further sequence independently having z amino acids, wherein m is an integer from 0-10 and z is an integer from 1-20, and wherein the peptide further comprises an amino acid sequence facilitating cellular uptake of the peptide; wherein said peptide is more cytotoxic to, or more inhibiting to, the growth of a cancer cell than a control cell and/or a non-cancerous cell.