Patent ID: 7479494

Claim:
A compound represented by the formula or a pharmaceutically acceptable salt thereof, wherein R 1 is R 4 -aryl-, R 4 -arylalkyl-, R 4 -heteroaryl-, R 4 -heteroarylalkyl-, R 4 -cycloalkyl-, R 4 -cycloalkylalkyl-, R 4 -heterocycloalkyl-, R 4 -heterocycloalkylalkyl-; R 2 is R 5 -aryl-, R 5 -arylalkyl-, R 5 -heteroaryl-, R 5 -heteroarylalkyl-, R 5 -cycloalkyl-, R 5 -cycloalkylalkyl-, R 5 -heterocycloalkyl-, R 5 -heterocycloalkylalkyl-; R 3 is R 6 -alkyl-, R 6 -aryl-, R 6 -heteroaryl-, R 6 -cycloalkyl-, R 6 -heterocycloalkyl-; X is a bond, (C 1 -C 3 )alkylene, —(CH 2 ) m —N(R 7 )—(CH 2 ) n —, —(CH 2 ) m —O—(CH 2 ) n —, —(CH 2 ) m —S—(CH 2 ) n —, —C(O)—, —CH(OH)—, —C(O)N(R 7 )—, —C(O)N(R 7 )-alkylene or —N(R 7 )C(O)—; n is 0, 1, 2, 3; 4, 5 or 6; m is 0, 1, 2, 3; 4, 5 or 6; provided that the sum of m and n is 0, 1, 2, 3; 4, 5 or 6; each R 4 and R 5 is 1 to 3 substituents independently selected from the group consisting of H, halo, alkyl, cycloalkyl, —CN, —CF 3 , —(CH 2 ) p —OR 8 , —N(R 10 ) 2 and —(CH 2 ) n —N(R 10 ) 2 ; R 6 is 1 to 3 substituents independently selected from the group consisting of H, halo, alkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, —CN, cyanoalkyl, —CF 3 , —C(O)alkyl, —(CH 2 ) p —OR 8 , —COOR 8 , —N(R 10 ) 2 , —(CH 2 ) n —N(R 10 ) 2 and —C(O)N(R 10 ) 2 ; p is 0, 1, 2, 3; 4, 5 or 6; R 7 is H or alkyl; R 8 and R 9 are independently selected from the group consisting of H, alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, aminoalkyl, alkyl-C(O)— and alkyl-C(O)—N(R 7 )—C(O)—; and R 10 is independently selected from the group consisting of H and alkyl.