Patent ID: 7067263

Claim:
A method of screening one or more test compounds for an effect on at least one cell using an analytical device comprising: flowing one or more test compounds from one or more test compound sources through one or more microfluidic channels of an analytical device fabricated in a planar substrate, wherein the one more microfluidic channels have at least one cross-sectional dimension in a range from about 0.1 to 500 μm; contacting the one or more test compounds with at least a first cell; and detecting a cellular response of the at least first cell to the one or more test compounds in a detection zone of the device, wherein the cellular response is selected from the group consisting of cell proliferation, cell differentiation, cell activation, activation of a cell activity mediating enzyme, stimulation of messenger turnover in the cell, alteration of cell ion flux, activation of cellular enzymes, changes in cell shape, and an alteration in expression of a gene.